bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated Serum Xanthine Oxidase Activity Is Associated With the Development of Type 2 Diabetes: A Prospective Cohort Study
Authors: Li Xue , Meng Xing , Gao Xiangchun , Pang Xiuyu , Wang Yanjiao , Wu Xiaoyan , Deng Xinrui , Zhang Qiao , Sun Changhao , Li Ying 
Published: February 2018

OBJECTIVE
We aimed to evaluate whether xanthine oxidase (XO), a key enzyme in uric acid (UA) metabolism and a major source of reactive oxygen species, plays a causal and important role in the development of type 2 diabetes mellitus (T2DM) in a large prospective cohort study.

RESEARCH DESIGN AND METHODS
A total of 4,412 diabetes-free adults (2,071 women and 2,341 men) aged 30–65 years at baseline in 2008 were involved. Participants were followed for incident change of glucose metabolism during an average of 4.7 years. At baseline, serum XO and UA, serum lipids, and glucose homeostasis indexes including fasting blood glucose (FBG), 2-h blood glucose (PBG), glycosylated hemoglobin A1c (HbA1c), and fasting insulin were tested for analysis.

RESULTS
During an average follow-up period of 4.7 years, 249 women and 360 men developed new-onset T2DM. Serum XO activity was positively associated with UA concentration (all P values &lt;0.001). When XO activity and UA concentration were considered in the same model of the sex-specific analysis, only XO activity was significantly associated with the incidence of T2DM, with the hazard ratios from the bottom to the top quartile of XO activity being 1.00, 1.67 (95% CI 1.00–2.79), 1.86 (1.11–3.13), and 2.36 (1.43–3.90) in women and 1.00, 1.01 (0.68–1.52), 1.41 (0.98–2.03), and 1.90 (1.30–2.78) in men.

CONCLUSIONS
Elevated serum XO activity, but not UA concentration, was associated with an increased risk of developing T2DM in women and men with mutual adjustment for XO and UA. Further studies are needed to examine the underlying mechanisms.
Increasing Mortality in Adults With Diabetes and Low Estimated Glomerular Filtration Rate in the Absence of Albuminuria
Authors: Kramer Holly , Boucher Robert E. , Leehey David , Fried Linda , Wei Guo , Greene Tom , Rosas Sylvia E. , Cooper Richard , Cao Guichan , Beddhu Srinivasan 
Published: February 2018

OBJECTIVE
Improved blood pressure control and use of renin-angiotensin-aldosterone system blockers have altered the clinical presentation or phenotype of chronic kidney disease (CKD) in U.S. adults with diabetes. These changes may influence mortality.

RESEARCH DESIGN AND METHODS
Data from the National Health and Nutrition Examination Surveys (NHANES) 1988–2006 were used to examine mortality trends in adults with diabetes, defined as physician diagnosis, fasting glucose ≥126 mg/dL, HbA1c &gt;6.5% (48 mmol/mol), or use of glucose-lowering medications. Mortality trends by CKD phenotype (estimated glomerular filtration rate [eGFR] and urine albumin-to-creatinine ratio [ACR] level) were obtained via linkage with the National Death Index through 31 December 2011 while accounting for the complex survey design.

RESULTS
From 1988 to 2006, adults with an eGFR &lt;60 mL/min/1.73 m2 and an ACR &lt;30 mg/g increased from ∼0.9 million (95% CI 0.7, 1.1) or 6.6% of the total population with diabetes during years 1988–1994 to 2.4 million (95% CI 1.9, 2.9) or 10.1% of the total population with diabetes during years 2007–2010. Mortality rates generally trended downward for adults with diabetes and an ACR ≥30 mg/g but increased in those with eGFR &lt;60 mL/min/1.73 m2 and an ACR &lt;30 mg/g from 35 deaths per 1,000 person-years (95% CI 22, 55) during years 1988–1994 to 51 deaths per 1,000 person-years (95% CI 33, 83) during years 2003–2006.

CONCLUSIONS
ACR values are decreasing in U.S. adults with diabetes, but optimal management strategies are needed to reduce mortality in those with a low eGFR and an ACR &lt;30 mg/g.
Perancangan Sistem Pendukung Keputusan Penentuan Impor Bawang Merah
Authors: Widayani Wiwi , Kusrini Kusrini , Fatta Hanif Al 
Published: February 2018

Pertambahan jumlah penduduk Indonesia serta meningkatkannya permintaan industri akan bawang merah yang tidak diimbangi dengan jumlah produksi mendorong pemerintah membuka impor bawang merah. Impor dilakukan untuk menjaga keseimbangan harga dan pasokan bawang merah sehingga inflasi yang diakibatkan kenaikan harga bawang merah dapat ditekan, namun impor yang tidak tepat jumlah akan mengakibatkan kerugian bagi pihak petani, perlu adanya sistem pendukung dalam menentukan volume impor guna menjaga keseimbangan harga pasar dan pemenuhan kebutuhan bawang merah. Sistem pendukung keputusan yang dirancang menerapkan Fuzzy Inference System (FIS) Tsukamoto. Sistem yang dirancang memungkinkan pengguna untuk melakukan training data dan testing data, proses dalam training data yaitu : 1)Clustering data latih, menggunakan algoritma K-Means 2)Ekstraksi Aturan, 3)Testing data latih, hitung nilai impor dengan fuzzy Tsukamoto, 4)Menganalisa error hasil fuzzy menggunakan MAPE(Means Absolute Percentage Error), 5)Testing Data Uji dan menganalisa hasil error data uji. Hasil Uji Model menunjukan penentuan impor bawang merah dengan parameter input harga petani, harga konsumen, produksi, konsumsi, harga impor dan kurs terhadap 60 data latih menghasilkan error terendah sebesar 0.07 pada 12 cluster, hasil uji mesin inferensi terhadap data uji menghasilkan error sebesar 0.25. Indonesian population growth and increase industrial demand shallot is not matched with number of production prompted the government to opened shallot imports. Import done to maintain the balance price and supply of shallot so inflation caused by rising prices of onion can be suppressed, but not the exact amount of imports would result in losses for the farmers, support system in determining volume imports is need to maintain balance of market price and needs of shallot. Decision support system designed to apply Fuzzy Inference System (FIS) Tsukamoto. The system is allows the user to perform the training data and testing data, the training process performs are: 1) Clustering training data, using the K-Means algorithm 2) Extraction Rule, 3) Testing data, calculate imports value by fuzzy Tsukamoto, 4) analyze the results error using MAPE (Means Absolute Percentage error), 5) testing test data and analyze the results error. The results show the determination of imported shallot with input parameters producer prices, consumer prices, production, consumption, import prices and the exchange rate against 60 training data produces the lowest error of 0:07 in 12 clusters, the inference engine test resulted in an error of 0.25.
Kendali Logika Fuzzy Pada Robot Line Follower
Authors: David David 
Published: February 2018

Pada Penelitian ini, dirakit dan dikodekan program sebuah robot line follower menggunakan sensor cahaya. Logika fuzzy digunakan sebagai kendali dalam mengidentifikasi kecepatan robot agar dapat bergerak dan berjalan sesuai dengan jalur/garis pita berwarna hitam. Metode yang digunakan adalah metode Mindstorms dengan robot line follower berbasiskan microcontroller seri ATMega16. Metode ini adalah metode sederhana yang terdiri dari empat tahapan yaitu mencari ide untuk robot, membangun robot, memprogram robot dan dokumentasi. Pemrograman robot dengan menggunakan bahasa pemrograman BASCOM AVR digunakan untuk mendapatkan program yang bekerja terbaik. Pengujian dilakukan terhadap penggunaan sensor, motor DC dan ketelitian gerak line follower. Robot line follower yang dibuat dengan menggunakan microcontroller ATMega16 dapat melakukan scanning jalur pita berwarna hitam dan laju pergerakan berdasarkan kendali logika fuzzy.In this study, assembled and coded program a line follower robot using a light sensor. Fuzzy logic is used as a control in order to identify the speed of the robot can move and run in accordance with the path / line black ribbon. The method used is a method Mindstorms robot line follower based microcontroller ATmega16 series. This method is a simple method that consists of four stages, namely looking for ideas for robots, building robots, robot programming and documentation. Programming robots using BASCOM AVR programming language used to get a program that works best. Tests conducted on the use of sensors, DC motors and precision motion line follower. Line follower robot created using ATmega16 microcontroller can scan a black ribbon path and rate of movement is based on fuzzy logic control.
Rancangan Lowongan Kerja Online Menggunakan Metode User Centered Design (Studi Kasus: Business Placement Center STMIK AMIKOM Yogyakarta)
Authors: Sari Rhomita , Utami Ema , Amborowati Armadyah 
Published: February 2018

Business Placement Center membantu mengelola website alumni dalam memenuhi kebutuhan alumni salah satunya memberikan informasi mengenai lowongan pekerjaan. Website Alumni Amikom sudah memberikan informasi mengenai lowongan pekerjaan. Namun website alumni masih perlu ditambahkan fitur-fitur menu penunjang dalam mempermudah pencarian informasi pekerjaan yang sesuai keinginan pengguna. Penggunaan metode User Centered Design untuk mempermudah pengguna dalam menggunakan fasilitas yang ada pada website ketika mencari informasi lowongan pekerjaan dan pengguna berperan penting dalam setiap proses UCD. Dengan pendekatan User Centered Design diharapkan dapat menghasilkan tampilan dan fungsionalitas yang maksimal pada rancangan sistem yang dibangun sehingga sesuai dengan kebutuhan pengguna. Metode penelitian yang dilakukan yaitu observasi, wawancara dan kuesioner untuk mengetahui kebutuhan pengguna. Analisis dan perancangan menggunakan pendekatan User Centered Design dan implementasi perancangan sistem. Hasil penelitiannya adalah pengguna merasa nyaman dengan tampilan antarmuka website yang sudah dibangun, informasi yang disajikan mudah dipahami dan fitur-fitur menu sudah berhasil berjalansesuai fungsi.Business Placement Center help manage the website for the needs of alumnus one of them is to provide information on a vacancy. The alumnus website’s provides information about job vacancy. The website still need the support to facilitate the searching all the features the work in accordance with what the use. The method of user centered design to make it easy for users in the use of the existing facilities at the website while searching for information a vacancy and users play an important role in any proses UCD. User Centered Design approach is expected to produce the interface and functionality maximal built in the system so that in accordance with the need of users. Research methodology was by observation, interviews and quesionnaires to find out the need of users. Analysis and design using UCD approach and implementation of the system. The results of research is users feel comfortable with a display interface of website which have been built, the information is easily understood and menu features has been successfully run a function.
Perancangan Data Warehouse pada Laporan PDPT di Kopertis Wilayah V
Authors: Kumoro Sukarsono Windu , Rosidi Abidarin , Amborowati Armadyah 
Published: February 2018

Evaluasi terhadap Program Studi pada Perguruan Tinggi Swasta (PTS) yang memperoleh Ijin Penyelenggaraan dari Dirjen Dikti dibutuhkan oleh Koordinator Kopertis Wilayah V. Laporan PDPT telah terkumpul sejak tahun akademik 2002 semester ganjil (2002-1) sampai dengan tahun akademik 2013 semester genap (2013-2) yang terdiri dari data transaksi yang terkait dengan proses belajar mengajar di PTS. Laporan PDPT dari PTS dikerjakan atas dasar “Culture Trust”. Untuk mengatasi permasalahan tersebut dibangun sebuah data warehouse di Kopertis Wilayah V DIY. Data warehouse ini dikembangkan dengan menggunakan Foxpro dan Clipper dikarenakan data yang dilaporkan menggunakan file berekstendi DBF. Foxpro dan Clipper adalah sebuah paket basisdata dan dapat didistribusikan.Dalam pengerjaan pembangunan data warehouse ini akan melalui proses ETL dan pembuatan Star Schema (Skema Bintang) berupa dimensi-dimensi yang terhubung dengan tabel fakta berupa tabel aktifitas perkuliahan mahasiswa, evaluasi program studi dan aktifitas dosen mengajar di seluruh program studi pada PTS yang menjadi binaan Kopertis Wilayah V. Kemudian hasil data warehouse akan dianalisa melalui proses OLAP (On-line Analytical Processing).The evaluation of the Program on Private Higher Education (PTS) which derive from the Operating Licence required by the Coordinator General of Higher Education Kopertis Region V. PDPT reports have been collected since 2002 semester of the academic year (2002-1) until the second semester of academic year 2013 (2013-2), which consists of transaction data associated with the teaching and learning process in the PTS. PDPT reports of PTS is done on the basis of "Culture Trust".To overcome these problems built a data warehouse in Kopertis Region V DIY. The data warehouse was developed using FoxPro and Clipper because the data reported using a DBF file extension. FoxPro and Clipper is a package database and can be distributed. In the execution of data warehouse development is going through the ETL process and the making of Star Schema (Star Schema) in the form of dimensions that are connected with the fact table in the form of table activity lecturing students, evaluation of courses and activities throughout the faculty teaching courses at private universities being built Kopertis region V. Then the results will be analyzed data warehouse through a process of OLAP (On-line Analytical Processing).
Peran dan Tantangan Aktivis Yayasan Gaya Dewata dalam Kegiatan Pencegahan dan Penanggulangan HIV dan AIDS di Provinsi Bali
Authors: Mahadewi Ni Made Anggita Sastri 
Published: February 2018

Abstract This research discusses roles and challenges encountered by the activists of Yayasan Gaya Dewata (Gaya Dewata Foundation) in their efforts to prevent HIV infection and AIDS among gays and transgenders in Bali. This research applies qualitative approach to examine the actions conducted by the activists in three regions of Bali Province: Denpasar City, Badung Regency, and Gianyar Regency. The actions include field and cyber outreach, interactive group discussion, HIV counseling and testing, condom and lubricant distribution to gays and transgenders; and social support for people living with HIV and AIDS (PLHA). This research applies social action and simbolic interactionism theory to analyse several actions by the activists. This research finds that the actions by the activists of demonstrate a rational-instrumental and affective action as well as a symbolic interactionism action in the context of HIV and AIDS prevention. Keywords: Yayasan Gaya Dewata, gays and transgender, HIV, AIDS, Bali Abstrak Penelitian ini membahas peran dan tantangan yang dihadapi oleh para aktivis di Yayasan Gaya Dewata dalam upaya mereka mencegah infeksi HIV dan AIDS di kalangan gay dan waria di Bali. Penelitian ini menerapkan pendekatan kualitatif untuk mengamati kegiatan yang dilakukan para aktivis di tiga wilayah di Provinsi Bali: Kota Denpasar, Kabupaten Badung, dan Kabupaten Gianyar. Kegiatan para aktivis meliputi; penjangkauan lapangan dan online, diskusi kelompok interaktif, konseling dan tes HIV, pembagian kondom dan pelican bagi para gay dan waria, dan dukungan sosial bagi orang dengan HIV dan AIDS (ODHA). Penelitian ini menggunakan teori tindakan sosial dan interaksionisme simbolik untuk menganalisis kegiatan yang dilakukan para aktivis. Penelitian ini menemukan bahwa kegiatan yang dilakukan para aktivis menunjukkan sebuah bentuk tindakan sosial rasional-instrumental dan sebuah interaksi simbolik dalam konteks pencegahan HIV dan AIDS. Kata kunci: Yayasan Gaya Dewata, gay, waria, HIV, AIDS, Bali.
Simav Fayındaki Düşey Yerdeğiştirmelerin, GPR (Yeraltı Radarı) Yöntemi ile Belirlenmesi
Authors: GÜNDOĞDU Erdem , KURBAN Yunus Can , YALÇINER Cahit Çağlar , ÖZDEN Süha 
Published: February 2018

Son yıllarda yer bilimleri araştırmalarında, sığ derinliklerdeki yeraltına ait bilgilerin detaylı ve hızlı belirlenmesinde kullanılan sığ jeofizik uygulamalardan biri Yeraltı Radarı (Ground Penetrating Radar/GPR) yöntemidir. Bu çalışmada; Simav ve civarında yer alan aktif faylar boyunca, daha önce saha çalışmaları ile belirlenen 3 farklı lokasyonda toplam 5 adet profil ile fayın doğrultusuna dik olacak şekilde GPR çalışmaları yapılmıştır. Bunun sonucunda, Simav civarında yer alan aktif faylardaki, düşey yöndeki yer değiştirme miktarları belirlenmeye çalışılmıştır. Yapılan çalışmalara göre; birinci GPR profilinin gerçekleştirildiği alanda 30 cm ile 80 cm arasında değişen atımlar, ikinci GPR profilinin gerçekleştirildiği alanda 50 cm ile 70 cm arasında değişen atımlar, üçüncü GPR profilinin gerçekleştirildiği alanda 40 cm atım verisi elde edilmiştir. Tüm bu atım verileri; günümüzde bir miktar doğrultu atım bileşenine sahip olan, ancak ana karakteri normal fay olan Simav Fayı’nın düşey atım verilerini temsil etmektedir. Tüm bu veriler, yapılacak olan paleosismoloji çalışmaları için bir altlık oluşturmakta olup, verilerin ve yorumların kesin doğruluğu ancak paleosismoloji çalışmaları sonucunda belirlenebilir.
PERAN MUTASI GEN ACY II TERHADAP PRODUKSI ANTIBIOTIK SEFALOSPORIN
Authors: Mustika Indria Puti , Wibisana Ahmad 
Published: February 2018

The Roles of AcyII Gene Mutations for Production of Antibiotics Derived From CephalosporinSemisynthetic antibiotics cephalosporins are widely used to treat infectious diseases, especially those caused by gram-negative bacteria. Various types of semisynthetic antibiotics could be synthesized using 7-aminocephalosporanic acid (7-ACA) as the main raw material. 7-ACA is obtained by conversion of cephalosporin C, either chemically or enzymatically. Converting cephalosporin C to 7-ACA enzymatically in one step involves the cephalosporin acylase enzyme. Currently, all of cefalosporin acylase enzymes produced by wild-type microbes have only high activity on glutaryl-7-ACA as the main substrate. Genetic engineering of the encoding gene of cefalosporin acylase is required to obtain recombinant enzyme having high activity on cephalosporin C. In this paper, the engineering attempts made on acyII gene from Pseudomonas SE83 using directed mutagenesis, error prone PCR, and structural modeling are described. Keywords: AcyII gene, cephalosporin, cephalosporin C acylase, enzyme activity, mutation ABSTRAKAntibiotik sefalosporin semisintetik banyak digunakan untuk mengatasi penyakit infeksi, khususnya yang ditimbulkan oleh bakteri gram negatif. Berbagai jenis antibiotik semisintetk dapat disintesis menggunakan senyawa asam 7-aminosefalosporanat (7-ACA) sebagai bahan baku utamanya. Senyawa 7-ACA diperoleh melalui konversi sefalosporin C, baik yang dilakukan secara kimiawi maupun enzimatis. Konversi sefalosporin C menjadi 7-ACA secara enzimatis dalam satu langkah melibatkan enzim sefalosporin asilase. Hingga saat ini, seluruh enzim sefalosporin asilase yang dihasilkan oleh mikroba wild type hanya mempunyai aktifitas yang tinggi terhadap glutaryl-7-ACA. Rekayasa genetik terhadap gen pengkode enzim sefalosporin asilase diperlukan untuk memperoleh enzim rekombinan yang mempunyai aktifitas tinggi terhadap substrat sefalosporin C. Dalam ulasan ini diuraikan upaya-upaya rekayasa yang telah dilakukan terhadap gen acyII dari Pseudomonas SE83 menggunakan teknik mutasi terarah, error prone PCR, dan pemodelan struktur.Kata kunci: Aktivitas enzim, gen acyII, mutasi, sefalosporin, sefalosporin C asilase Received: 14September 2017 Accepted: 19 December 2017 Published: 30 December 2017 Received: 14September 2017 Accepted: 19 December 2017 Published: 30 December 2017
Relación entre el perfeccionismo socialmente prescrito y la conducta agresiva durante la infancia tardía
Authors: García-Fernández José Manuel , Vicent María , Ingles Cándido J. , Gonzálvez Carolina , Sanmartín Ricardo 
Published: February 2018

El objetivo de este trabajo consistió en examinar la relación entre el perfeccionismo socialmente prescrito (PSP) y la agresividad, atendiendo a sus componentes: fisiológico-emocional (ira), motor (agresividad física y verbal) y cognitivo (hostilidad). Se empleó una muestra de 776 alumnos de tercero a sexto curso de Educación Primaria (M = 9.72; DE = 1.14), así como la Child and Adolescent Perfectionism Scale y el Aggression Questionnaire para evaluar, respectivamente, el PSP y los componentes de la conducta agresiva: Ira, Hostilidad, Agresividad Física y Agresividad Verbal. Los análisis de diferencia de medias mostraron que los alumnos con altos niveles de PSP puntuaron significativamente más alto en las 4 subescalas del Aggression Questionnaire, en comparación con sus iguales con bajos niveles de PSP, obteniendo tamaños del efecto moderados en todos los casos, excepto para la variable Hostilidad, cuya magnitud de las diferencias encontradas fue pequeña. Los análisis de regresión logística revelaron que las 4 dimensiones del Aggression Questionnaire predijeron significativa y positivamente altas puntuaciones en PSP, con niveles de OR que oscilaron entre 1.07 y 1.12. Los resultados evidencian que existe una estrecha relación entre el PSP y las manifestaciones de la agresividad.
Perfiles de regulación emocional y estrés académico en estudiantes de fisioterapia
Authors: González Cabanach Ramón , Souto-Gestal Antonio , Fernández Cervantes Ramón 
Published: February 2018

El objetivo de este estudio es identificar los diferentes perfiles de regulación emocional presentes en una muestra de estudiantes universitarios y analizar si entre los perfiles identificados existen diferencias en la percepción de estresores académicos y en las respuestas psicofisiológicas de estrés.
Participaron 504 estudiantes de fisioterapia de diferentes universidades españolas, el 74% de sexo femenino y con una edad promedio de 21.06 ± 3.74 años a los que se les administró la Escala de Dificultades en la Regulación Emocional (DERS) y el Cuestionario de Estrés Académico (escala de estresores [ECEA] y escala de respuesta [RCEA]).
El análisis de conglomerados identificó tres perfiles de regulación: alta regulación emocional, baja regulación emocional y baja regulación emocional con alta atención.
Se obtuvieron diferencias estadísticamente significativas entre los diferentes perfiles tanto para la percepción de estresores como para las respuestas psicofisiológicas de estrés. Los estudiantes con un perfil de alta regulación emocional percibieron en menor medida el entorno académico como amenazante y experimentaron con menor frecuencia manifestaciones psicofisiológicas de estrés. Los estudiantes con perfiles de baja regulación y baja regulación con alta atención emocional mostraron resultados similares, a excepción de las alteraciones del sueño. En conclusión, los estudiantes de fisioterapia con elevadas puntuaciones en control y aceptación de sus estados emocionales perciben las circunstancias académicas de forma más adaptativa y experimentan menores respuestas de estrés.