bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression
Authors: Zhou Yuan-Chen , Wang Qian-Qian , Zhou Ge-Yu-Jia , Yin Teng-Fei , Zhao Dong-Yan , Sun Xi-Zhen , Tan Chang , Zhou Lei , Yao Shu-Kun 
Published: November 2024

BACKGROUND
The 5-year survival rate of patients with colorectal cancer (CRC) in China is only 56.9%, highlighting the need for new therapeutic drugs. Previous studies have shown that matrine exhibits antitumor effects by inducing apoptosis. However, the mechanism by which matrine regulates antiapoptotic proteins in CRC remains unclear.
AIM
To identify apoptotic proteins from proteomics and investigate the role of matrine in impeding CRC apoptosis by regulating these proteins.
METHODS
Tumor and adjacent normal tissues were collected from 52 patients with CRC who underwent surgery between January and December 2021. Data-independent acquisition quantitative proteomic analysis was performed to identify differentially expressed apoptotic proteins. The selected apoptotic proteins were identified through their association with tumor-node-metastasis (TNM) stage and prognosis, then confirmed by immunohistochemical (IHC) staining in validation cohort. In vitro , the role of matrine or apoptotic proteins on cancer cells were analyzed.
RESULTS
Compared to normal tissues, 88 anti-apoptotic proteins from proteomic results were selected. Among them, Shank-associated RH domain interactor (SHARPIN) was identified because of its relationship with TNM stage and overall survival in TCGA database. In the IHC-confirmed cohort, SHARPIN was highly expressed in CRC tissues and localized in the cytoplasm. Higher SHARPIN expression was associated with TNM stage, carbohydrate antigen 153 levels, and gross type compared to low expression. SHARPIN knockdown promoted apoptosis, significantly upregulated the expression of Bcl-2 associated agonist of cell death, Bcl-2 associated X protein, caspase 3, and caspase 8, and downregulated B-cell lymphoma-2 (P < 0.05). Importantly, matrine treatment promoted apoptosis and reversed the proliferation, invasion, and migration of CRC cells by repressing SHARPIN.
CONCLUSION
SHARPIN was identified as an upregulated anti-apoptotic protein in CRC, and matrine exhibited anticancer effects by downregulating its expression. Thus, matrine appears to be a promising drug for CRC.
Effect of Ashitaba Extract on Cholesterol in Wistar Rats Given a High-Fat Diet and Computational Lethal Dose Test
Authors: Widyaningsih Indah , Nurulita Sugiharto Natasya , Rahmawati Febtarini , Amma Fuad , Simamora Dorta 
Published: November 2024

High cholesterol levels in the blood can cause various health problems, namely atherosclerosis, stroke, coronary heart disease, and hypertension. One drug option for someone with hypercholesterolemia is simvastatin. Apart from using simvastatin, you can consume medicinal plants. A medicinal plant that can help reduce high cholesterol levels is Ashitaba (Angelica keiskei) leaf extract. One of the ingredients in Ashitaba extract is xanthoangelol E, Ashitaba chalcones, which can reduce cholesterol synthesis. The aim of this research was to determine the effect of ashitaba (Angelica keiskei) extract on the cholesterol levels of Wistar rats (Rattus novergiccus) given a high-fat diet. In this study, a computational lethal dose test was also carried out. The population in this study was male white rats of the Wistar strain with 30 samples taken. Analysis of this research data uses the One Way Anova statistical test. The results of the study showed that giving ashitaba extract 150mg/kg BW, 300mg/kg BW, and 600mg/kg BW had no effect on the cholesterol levels of Wistar rats given a high-fat diet. This is proven by the results of the Anova test which obtained a significance value of 0.761 > 0.05. Research regarding the toxic effects of ashitaba extract needs to be carried out for further research.
An improved circuit model for the estimation of the electromagnetic energy coupling throughout aperture into metallic enclosure
Authors: Kihal Mohammed Charif , Azizi Hakim , Chebout Mohammed , Sekki Daoud , Kihal Marouane , Moulai Hocine 
Published: November 2024

The development and exploration of approximate phenomenological models used to calculate the electromagnetic energy coupling throughout apertures into metallic enclosures is presented in this paper. An analytical approach has been established for the calculation of the electric and magnetic shielding effectiveness (SE, SM) a rectangular metallic enclosure with an aperture and conductor in it by means of Robinson's model. With the existence of inductive and capacitive obstacles, the modal technique is to complete the first one to estimate SE and SM exactly taking into consideration the maximum of propagating modes. The results of the SE and SM obtained by the analytical model are validated by the software CST/EMC and the Finite-Difference Time Domain method (FDTD). Very similar results are obtained between these methods.
Peran Pemerintah Kabupaten Pasaman Dalam Pembangunan Daerah Tertinggal di Kecamatan Simpang Alahan Mati
Authors: Azahra Putri Nabilah , Eriyanti Fitri 
Published: November 2024

Menurut Peraturan Presiden Republik Indonesia No. 63 Tahun 2020 tentang penetapan daerah tertinggal, Daerah Tertinggal adalah daerah kabupaten yang wilayahnya serta masyarakatnya kurang berkembang dibandingkan daerah lain dalam skala nasional. Pembangunandaerah tertinggal merupakan upaya yang dilakukan untuk meningkatkan kesejateraan masyarakat di daerah yang masih mengalami ketertinggalan dari daerah lainnya Penelitian ini bertujuan untuk menganalisis PERAN PEMERINTAH KABUPATEN PASAMAN DALAM PEMBANGUNAN DAERAH TERTINGGAL DI KECAMATAN SIMPANG ALAHAN MATI. Studi ini berjenis kualitatif menggunakan pendekatan deskriptif dan sudut pustaka serta studi wawancara, observasi, dan dokumentasi. Hasil studi menunjukkan bahws Peran pemerintah Kabupaten Pasaman dalam pembangunan daerah tertinggal di Kecamatan Simpang Alahan Mati yaitu di Nagari Alahan Mati Hilia dan Simpang Utara belum optimal. Hal ini dikarenakan pembangunan infrastruktur yang belum terlaksana seperti Minimnya sarana dan prasarana pendidikan, kesehatan dan peralatan kesehatan; Akses tranportasi yang buruk yaitu kondisi jalanan yang berlubang; Masih rendahnya perekonomian Masyarakat Nagari Alahan Mati Hilia dan Simpang Utara mayoritas perekonomian pada sektor pertanian dan perkebunan: Ketersediaan air bersih yang belum merata masyarakat yang masih keberatan dengan biaya layanan air bersih, dan juga kebiasaan masyarakat yang masih menggunakan air sumur dan air sungai untuk keperluannya; Akses jaringan internet masih terbatas dikarenakan letak geografis Nagari Alahan Mati Hilia dan Simpang Utara berada di antara perbukitan maka dari itu jangkauan internetnya pun terhambat.
МЕТОД ОПРЕДЕЛЕНИЯ ДРЕЙФА ГРАВИМЕТРА CG-6 AUTOGRAV ДЛЯ ОБЕСПЕЧЕНИЯ ВЫСОКОТОЧНЫХ ИЗМЕРЕНИЙ СИЛЫ ТЯЖЕСТИ
Authors: Х.М. Касымканова , Э.О. Орынбасарова , А.С. Уразалиев , К.А. Жанакулова 
Published: November 2024

Вопрос обеспечения высокоточными данными о силе тяжести Земли в рамках реализации проекта «Разработка модели геоида Республики Казахстан, как основа единой государственной системы координат и высот» является первостепенной задачей для достижения поставленной цели. Построение модели геоида и гравиметрического полигона невозможно без применения современных технологий. Сегодня измерить силу тяжести с высокой точностью возможно лишь с применением гравиметров. Современные гравиметры просты в использовании, надежны и эффективны при проведении гравиметрических измерений. В статье проведены тестовые измерения относительных значений силы тяжести на территории кампуса Satbayev University цифровым гравиметром CG-6 Autograv. Определена скорость дрейфа гравиметра, дана оценка точности проводимых измерений
«Координаттар мен биіктіктердің біртұтас мемлекеттік жүйесінің негізі ретінде Қазақстан Республикасының геоидтық моделін жасау» жобасын іске асыру шеңберінде Жердің ауырлық күші туралы жоғары дәлдіктегі деректермен қамтамасыз ету мәселесі алға қойылған мақсатқа қол жеткізу үшін бірінші кезектегі міндет болып табылады. Геоид пен гравиметриялық полигон моделін құру заманауи технологияларды қолданбай мүмкін емес. Бүгінгі таңда ауырлық күшін гравиметрлерді қолдану арқылы ғана жоғары дәлдікпен өлшеуге болады. Қазіргі гравиметрлерді пайдалану оңай, сенімді және гравиметриялық өлшеулер жүргізуде тиімді. Мақалада CG-6 Autograv сандық гравиметрімен Satbayev University кампусындағы ауырлық күшінің салыстырмалы мәндерін сынақтан өткізді. Гравиметрдің дрейф жылдамдығы анықталды, өлшеулердің дәлдігі бағаланды
The issue of providing high-precision data on the Earth’s gravity within the framework of the project «Development of a geoid model of the Republic of Kazakhstan as the basis of a unified state coordinate system and heights» is a primary task to achieve this goal. Building a model of a geoid and a gravimetric polygon is impossible without the use of modern technologies. Today, it is possible to measure gravity with high accuracy only with the use of gravimeters. Modern gravimeters are easy to use, reliable and effective in carrying out gravimetric measurements. In the article, test measurements of relative gravity values on the campus of Satbayev University with a digital gravimeter CG-6 Autograv were carried out. The gravimeter drift velocity was determined, and the accuracy of the measurements was estimated
ПРАВОВОЕ РЕГУЛИРОВАНИЕ УСТОЙЧИВЫХ ГОСУДАРСТВЕННЫХ ЗАКУПОК: КОМПАРАТИВНЫЙ АНАЛИЗ С УЧЁТОМ ЗАКОНОДАТЕЛЬСТВА РЕСПУБЛИКИ КАЗАХСТАН
Authors: Ж.Е. Раймбекова , А.М. Иманмадиева , М.А. Амирова , А.Е. Исмагулов 
Published: November 2024

Статья посвящена правовому регулированию зелёных государственных закупок, которое представляет собой актуальную и многогранную область исследования в контексте устойчивого развития и экологической ответственности. В рамках анализа рассматриваются ключевые аспекты законодательства Республики Казахстан, включая существующие нормы и инициативы, направленные на внедрение принципов «зелёной экономики». Кросс-национальный анализ предполагает сопоставление казахстанской практики с международными стандартами и практиками, принятыми в различных странах, таких как страны Европейского Союза и США. Обсуждаются механизмы реализации зелёных закупок, а также их влияние на экологическую и экономическую устойчивость, социальные аспекты и управление ресурсами. Статья акцентирует внимание на правовых и организационных барьерах, с которыми сталкиваются государственные органы и коммерческие структуры, а также на перспективных подходах для улучшения законодательства в данной сфере. Результаты исследования подчеркивают необходимость более активной интеграции экологических критериев в систему государственных закупок, что может способствовать повышению эффективности расходования бюджетных средств и созданию благоприятной среды для развития «зелёного» бизнеса в Казахстане. В заключении формулируются рекомендации по совершенствованию правового регулирования зелёных государственных закупок, которые могут послужить основой для дальнейших научных исследований и практических решений в данной области.
The article is devoted to the legal regulation of green public procurement, which is a relevant and multifaceted area of study in the context of sustainable development and environmental responsibility. The analysis considers key aspects of the legislation of the Republic of Kazakhstan, including existing regulations and initiatives aimed at introducing the principles of the green economy. The cross-country analysis compares Kazakhstan's practices with international standards and practices adopted in various countries, such as the European Union countries and the USA. The mechanisms of implementation of green procurement are discussed, as well as its impact on environmental and economic sustainability, social aspects and resource management. The article focuses on the legal and organisational barriers faced by public authorities and businesses, as well as promising approaches for improving legislation in this area. The results of the study highlight the need for a more active integration of environmental criteria into the public procurement system, which can help to improve the efficiency of budget spending and create a favourable environment for the development of 'green' business in Kazakhstan. The conclusion formulates recommendations for improving the legal regulation of green public procurement, which can serve as a basis for further research and practical solutions in this area.
Analysis of Carbon Footprint from a Drilling Project in Niger Delta, Nigeria
Authors: Chukwu Emeke  , Ayanfeoluwa Obe  , Olugbenga Olamigoke  
Published: November 2024

Abstract: The oil and gas industry plays a significant role in the release of carbon emissions into the atmosphere. Therefore, it is crucial to accurately gauge and minimize its carbon footprint which requires the thorough measurement of emissions and the identification of the primary sources of carbon emissions. By doing so, we can then determine the most effective methods for reducing these emissions.
This study aims to precisely quantify and decrease the carbon footprint associated with drilling operations. To achieve this, we evaluated the diesel and petrol consumption from an onshore drilling project in the Niger Delta and used an emissions model to assess carbon dioxide (CO2) emissions from a drilling rig, thus gaining a comprehensive understanding of current emission levels and the potential for reduction. The data collected included the daily fuel consumption for power generation, transportation, and handling vehicles. The CO2 emissions resulting from fuel consumption were calculated and measured to be 103.5 metric tonnes.
Our analysis determined that the primary contributor to the emissions was the energy generation on the site, primarily from the generators. Additionally, it was found that the circulating system on the rig was the main source of CO2 emissions. The study underscores the necessity for long-term impact assessments of drilling fluids and new technologies, emphasizing the need for innovative solutions to further decrease emissions.
IMPLEMENTATION OF CHILD-FRIENDLY PESANTREN IN AN EFFORT TO PREVENT VIOLENCE AGAINST STUDENTS IN ISLAMIC BOARDING SCHOOLS
Authors: RAHMANUDIN II , YAKIN PAJRI AINUL , UMAM MUHAMMAD KHOERUL 
Published: November 2024

The rise of violence against children in the pesantren environment has been circulating in the mass media. So the problems that occur invite educators to be able to implement child-friendly pesantren to prevent violence against students in Islamic boarding schools. So the purpose of this study is to find out how the implementation of child-friendly pesantren in the pesantren environment, especially the Muthmainnatul Qulub AL Islami Pesantren Cibinong Bogor. And to what extent this boarding school has implemented Child-Friendly Pesantren by the guidelines of the Ministry of Religion? The research method used is a descriptive qualitative method with a case study approach. The data is taken from interview data, documentation, and observation. The data analysis uses triangulation data analysis. The result is that Pondok Pesantren Muthmainnatul Qulub AL Islami Cibinong Bogor West Java has carried out child-friendly pesantren procedures quite well with a percentage of 50% implementation but there are still many shortcomings and the need for a very deep evaluation to support the child-friendly pesantren program. So that there are no more cases of violence even if only in the form of bullying.
ABSTRAKMaraknya kekerasan pada anak di lingkungan pesantren sudah beredar di media masa. Sehingga problematika yang terjadi mengundang pada pendidik untuk bisa mengimplementasikan pesantren ramah anak dalam upaya mencegah kekerasan pada santri di Pondok Pesantren. Maka tujuan penelitian ini adalah mengetahui bagaimana implementasi pesantren ramah anak di lingkungan pesantren khususnya Pesantren Muthmainnatul Qulub AL Islami Cibinong Bogor. Dan sejauhmana pondok pesantren ini sudah mengimplementasikan Pesantren Ramah Anak sesuai dengan pedoman dari Kemenag. Metode penelitian yang digunakan ialah metode kualitatif deskriptif dengan pendekatan studi kasus. Adapun data diambil dari data wawancara, dokumentasi dan observasi. Analisis datanya menggunakan analisis data tringulasi. Hasilnya adalah bahwa di Pondok Pesantren Muthmainnatul Qulub AL Islami Cibinong Bogor Jawa Barat, sudah melakukan prosedur pesantren ramah anak dengan cukup baik dengan persentasi penerapan 50% namun masih banyak kekurangan dan perlunya evaluasi yang sangat dalam mendukung program pesantren ramah anak. Sehingga tidak ada lagi kasus kekerasan walaupun hanya dalam bentuk bullying.
Processes, spatial patterns, and impacts of the 1743 extreme-heat event in northern China: from the perspective of historical documents
Authors: Tao Le , Su Yun , Chen Xudong , Tian Fangyu 
Published: November 2024

Abstract. The study of historical extreme heat is helpful for understanding modern heatwaves. By collecting 63 historical documents from three kinds of historical materials and using text analysis methods based on keywords, grading, and classification, this research recovered and analysed the processes of extreme heat over time, the spatial patterns of heat severity, and the impacts of extreme heat in northern China during 1743. The results show the following. (1) The extreme heat of 1743 began to be noticed by people on 22 June; began to kill people on 14 July; and was at its most severe, attracting great attention from the central government, between 14 and 25 July. (2) Extreme heat occurred on the plains of the provinces of Hebei and Shandong and in the valleys of southwestern Shanxi. Areas of the plains east of the Taihang Mountains, such as Baoding, Shijiazhuang, and Xingtai, experienced the worst heat. These areas are also at high risk for heatwaves on the North China Plain in modern times. (3) In 1743, heat affected people, animals, plants, and facilities and had the most severe impact on human deaths. The death toll in a single county reached dozens in a single day. Timely cooling and reducing exposure have been limited but necessary means of addressing extreme heat in both ancient and modern times.
Size scaling of large landslides from incomplete inventories
Authors: Korup Oliver , Luna Lisa V. , Ferrer Joaquin V. 
Published: November 2024

Abstract. Landslide inventories have become cornerstones for estimating the relationship between the frequency and size of slope failures, thus informing appraisals of hillslope stability, erosion, and commensurate hazard. Numerous studies have reported how larger landslides are systematically rarer than smaller ones, drawing on probability distributions fitted to mapped landslide areas or volumes. In these models, much uncertainty concerns the larger landslides (defined here as affecting areas ≥ 0.1 km2) that are rarely sampled and often projected by extrapolating beyond the observed size range in a given study area. Relying instead on size-scaling estimates from other inventories is problematic because landslide detection and mapping, data quality, resolution, sample size, model choice, and fitting method can vary. To overcome these constraints, we use a Bayesian multi-level model with a generalised Pareto likelihood to provide a single, objective, and consistent comparison grounded in extreme value theory. We explore whether and how scaling parameters vary between 37 inventories that, although incomplete, bring together 8627 large landslides. Despite the broad range of mapping protocols and lengths of record, as well as differing topographic, geological, and climatic settings, the posterior power-law exponents remain indistinguishable between most inventories. Likewise, the size statistics fail to separate known earthquakes from rainfall triggers and event-based triggers from multi-temporal catalogues. Instead, our model identifies several inventories with outlier scaling statistics that reflect intentional censoring during mapping. Our results thus caution against a universal or solely mechanistic interpretation of the scaling parameters, at least in the context of large landslides.
Struck by the Arrow of Beauty: Saturated Phenomena and the (Theo)Drama of Subjectivity
Authors: Power Cormac 
Published: November 2024

ABSTRACT
This article is concerned with theological aesthetics and aims to show how aesthetic modes of experience create a context in which a subject can understand their existence in terms of (Christian) spiritual drama. It considers the ideas of twentieth-century Catholic theologian Hans Urs von Balthasar and of contemporary phenomenologist Jean-Luc Marion in order to show how aesthetic experience acts as a gateway through which the experiencing subject enters into a new, dramatically constituted spiritual space. Finally, this article illustrates this conception of a dramatized spiritual life by considering the writings of Saint Thérèse of Lisieux. Saint Thérèse, the author argues, models how a life that is otherwise obscure and “undramatic” may be “lifted” into the dramatic mode through experiences of faith as filtered through what Marion calls “saturated phenomena.”
Mitigating the Causes of Teenagers’ Involvements in Money Ritual and Related Activities in Ogun State, Nigeria
Authors: Soluade Zabur Olayiwola , Abdu-Raheem Bilqees Olayinka , Agboola Rukayat Opeyemi , Balogun Olukunle Olagunju , Atawodi Ibrahim 
Published: November 2024

This study assesses the mitigating causes of teenagers’ involvements in money rituals and related activities in Ogun State. The study sets out to assess the factors responsible for the pandemic of money ritual and suggests solutions to the upsurge of money ritual related killings among teenagers. The study employed a descriptive research design. The population for this study consists of all residences in Abeokuta South and Ado-Odo/Ota local government areas of Ogun state. Participants were selected using a purposive random sampling procedure. The main instrument for this study is a self-structured questionnaire tagged: “Teenager and Money Rituals Killings Questionnaire” (TMRKQ). (R =0.82). Data collected was coded and analysed using descriptive statistics of mean and standard deviation. The results show that factors such as greediness on the part of teenagers and peer group pressure contributed to teenagers' involvement in money rituals and factors such as promotion of hard work, good values system and conducts among the youths will reduce youth tendency of engaging in money rituals. Based on the findings, it is suggested that the government should punish offenders to serve as a deterrent to others and the government should improve on intelligent gathering techniques in reducing cases of money rituals killings in the country.