bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct Neural Mechanisms Meet Challenges in Dynamic Visual Attention due to Either Load or Object Spacing
Authors: Mäki-Marttunen Veronica , Hagen Thomas , Laeng Bruno , Espeseth Thomas 
Published: September 2019

Abstract
When engaged in dynamic visuospatial tasks, the brain copes with perceptual and cognitive processing challenges. During multiple-object tracking (MOT), the number of objects to be tracked (i.e., load) imposes attentional demands, but so does spatial interference from irrelevant objects (i.e., close encounters). Presently, it is not clear whether the effect of load on accuracy solely depends on the number of close encounters. If so, the same cognitive and physiological mechanisms deal with increasing load by preparing for and dealing with spatial interference. However, this has never been directly tested. Such knowledge is important to understand the neurophysiology of dynamic visual attention and resolve conflicting views within visual cognition concerning sources of capacity limitations. We varied the processing challenge in MOT task in two ways: the number of targets and the minimum spatial proximity between targets and distractors. In a first experiment, we measured task-induced pupil dilations and saccades during MOT. In a separate cohort, we measured fMRI activity. In both cohorts, increased load and close encounters (i.e., close spatial proximity) led to reduced accuracy in an additive manner. Load was associated with pupil dilations, whereas close encounters were not. Activity in dorsal attentional areas and frequency of saccades were proportionally larger both with higher levels of load and close encounters. Close encounters recruited additionally ventral attentional areas that may reflect orienting mechanisms. The activity in two brainstem nuclei, ventral tegmental area/substantia nigra and locus coeruleus, showed clearly dissociated patterns. Our results constitute convergent evidence indicating that different mechanisms underlie processing challenges due to load and object spacing.
Neural Dynamics of Serial Dependence in Numerosity Perception
Authors: Fornaciai Michele , Park Joonkoo 
Published: September 2019

Abstract
Serial dependence—an attractive perceptual bias whereby a current stimulus is perceived to be similar to previously seen ones—is thought to represent the process that facilitates the stability and continuity of visual perception. Recent results demonstrate a neural signature of serial dependence in numerosity perception, emerging very early in the time course during perceptual processing. However, whether such a perceptual signature is retained after the initial processing remains unknown. Here, we address this question by investigating the neural dynamics of serial dependence using a recently developed technique that allowed a reactivation of hidden memory states. Participants performed a numerosity discrimination task during EEG recording, with task-relevant dot array stimuli preceded by a task-irrelevant stimulus inducing serial dependence. Importantly, the neural network storing the representation of the numerosity stimulus was perturbed (or pinged) so that the hidden states of that representation can be explicitly quantified. The results first show that a neural signature of serial dependence emerges early in the brain signals, starting soon after stimulus onset. Critical to the central question, the pings at a later latency could successfully reactivate the biased representation of the initial stimulus carrying the signature of serial dependence. These results provide one of the first pieces of empirical evidence that the biased neural representation of a stimulus initially induced by serial dependence is preserved throughout a relatively long period.
Attentional Access to Multiple Target Objects in Visual Search
Authors: Berggren Nick , Eimer Martin 
Published: September 2019

Abstract
Most investigations of visual search have focused on the discrimination between a search target and other task-irrelevant distractor objects (selection). The attentional limitations that arise when multiple target objects in the same display have to be processed simultaneously (access) remain poorly understood. Here, we employed behavioral and electrophysiological measures to investigate the factors that determine whether multiple target objects can be accessed in parallel. Performance and N2pc components were measured for search displays that contained either a single target or two target objects. When two target objects were present, they either had the same or different target-defining features. Participants reported whether search displays contained a single target, two targets with shared features, or two targets with different features. There were performance costs as well as reduced N2pc amplitudes for two-target/different relative to two-target/same displays, suggesting that access to multiple target objects defined by different features was impaired. These behavioral and electrophysiological costs were also observed in a task where all search display objects were physically different, but not during color or shape singleton search, confirming that they do not reflect a low-level perceptual grouping of physically identical targets. These results demonstrate strong feature-specific limitations of visual access, as proposed by the Boolean map theory of visual attention. They suggest that multiple target objects can be accessed in parallel only when they share task-relevant features and demonstrate that mechanisms of visual access can be studied with electrophysiological markers.
Quaker Epistemology
Authors: Rediehs Laura 
Published: September 2019

Abstract
Quakerism emerged in the seventeenth century, during a time when philosophical debates about the nature of knowledge led to the emergence of modern science. The Quakers, in some conversation with early modern philosophers, developed a distinctive epistemology rooted in their concept of the Light Within, which functioned as a special internal sense giving access to divine insight. The Light Within provided illumination both to properly understand the Bible and to ‘read’ the Book of Nature. This epistemology can be thought of as an expanded experiential empiricism that integrates our ethical and religious knowledge with our scientific knowledge. This epistemology has carried through in Quaker thought to the present day and can be helpful in the context of today’s epistemological crisis.
Comparing Urban Maxillofacial Trauma Patterns to the National Trauma Data Bank©
Authors: Cohn Jason E. , Smith Kiara C. , Licata Jordan J. , Michael Alex , Zwillenberg Seth , Burroughs Tariem , Arosarena Oneida A. 
Published: September 2019

Objectives: We aimed to determine whether certain maxillofacial fracture patterns and injury mechanisms were more prevalent in an urban environment. In addition, we aimed to determine if maxillofacial trauma incidence correlated with income. Methods: Data was collected from Einstein Healthcare Network and Temple University Health System. These data were compared to the 2016 National Trauma Data Bank© (NTDB©) using chi-square analysis. Multivariate analysis was used to identify correlations between demographic variables and fracture patterns. Sociodemographic data was further characterized utilizing neighborhood mapping. Results: A total of 252 patients from our urban campuses and 14 447 patients from the NTDB© were identified with facial fractures. Maxillofacial trauma patients in the urban population were more likely to be minorities and less likely to be Caucasian compared to the NTDB© ( P < .001). Patients in the urban setting were more likely to sustain mandibular and orbital fractures, and less likely to sustain maxillary fractures and multiple fractures ( P < .001). Urban maxillofacial trauma patients were more likely to sustain assault and sporting injuries, and less likely to sustain injuries from motor vehicle accidents and self-harm ( P < .001). Conclusions: Maxillofacial trauma patterns and injury mechanisms were shown to be significantly different in an urban environment as compared to national data.
Carhart Notch—A Prognostic Factor in Surgery for Otosclerosis
Authors: Wiatr Agnieszka , Składzień Jacek , Strek Pawel , Wiatr Maciej 
Published: September 2019

Objective: Otosclerosis is an underlying disease of the bony labyrinth. This disorder, occurring only within the area of a person’s temporal bone, is characterized by a progressive hearing loss and tinnitus. Material and Methods: The study looked for the answer to the question of whether the presence or absence of Carhart notch in the presurgical tonal audiogram affects the final outcome of the otosclerosis surgery. Results: The analysis included 140 patients operated on for the first time due to otosclerosis between 2010 and 2016. The study group consisted of 107 women aged from 19 to 62 (average age: 40.33) and 33 men aged 27 to 59 (average age: 38.23). Analysis showed a statistically better result of stapedotomy in patients without the notch than in the same procedure in patients with the notch present. The opposite situation occurred in the case of stapedectomy. Conclusion: (1) The presence of a refraction of the bone conduction curve with a depth of 10 to 20 dB at a frequency of 2000 Hz (the so-called Carhart notch) in the presurgical tonal audiogram is an unfavorable prognostic factor in relation to closing the cochlear reserve and improving bone conduction after the stapedotomy. (2) Regardless of the presence or absence of Carhart notch in the presurgical tonal audiogram, stapedotomy is the procedure with the highest efficiency in the treatment of otosclerosis.
Acute stress in adolescence vs early adulthood following selective deletion of dysbindin-1A: Effects on anxiety, cognition and other schizophrenia-related phenotypes
Authors: Desbonnet Lieve , O’Tuathaigh Colm MP , O’Leary Clare , Cox Rachel , Tighe Orna , Petit Emilie I , Wilson Steve , Waddington John L 
Published: September 2019

Background: As exposure to stress has been linked to the onset and maintenance of psychotic illness, its pathogenesis may involve environmental stressors interacting with genetic vulnerability. Aim: To establish whether acute stress interacts with a targeted mutation of the gene encoding the neurodevelopmental factor dystrobrevin-binding protein 1 (DTNBP1), resulting in a specific loss of the isoform dysbindin-1A, to influence schizophrenia-relevant phenotypes in mice during adolescence and adulthood. Methods: Male and female mice with a heterozygous or homozygous deletion of DTNBP1 were assessed in the open field test following acute restraint stress in adolescence (Day 35) and young adulthood (Day 60–70). Effects of acute restraint stress on memory retention in the novel object recognition test was also assessed in adulthood. Baseline corticosterone was measured in serum samples and, brain-derived neurotrophic factor (BDNF), glucocorticoid and mineralocorticoid receptor gene expression levels were measured in the hippocampus of adult mice. Results: In the open field, deletion of dysbindin-1A induced hyperactivity and attenuated the action of stress to reduce hyperactivity in adolescence but not in adulthood; in females deletion of dysbindin-1A attenuated the effect of acute stress to increase anxiety-related behaviour in adolescence but not in adulthood. In the novel object recognition test, deletion of dysbindin-1A impaired memory and also revealed an increase in anxiety-related behaviour and a decrease in hippocampal BDNF gene expression in males. Conclusions: These data suggest that deletion of dysbindin-1A influences behaviours related to schizophrenia and anxiety more robustly in adolescence than in adulthood and that dysbindin-1A influences stress-related responses in a sex-dependent manner.
Reconstruction of pediatric hand injuries caused by automatic cup-sealing machines in Taiwan
Authors: Tsai Yueh-Ju , Carvajal Carolina Forero , Flores Nicolas Moltedo , Lin Tsan-Shiun , Yang Johnson Chia-Shen , Chiang Yuan-Cheng , Lin Pao-Yuan 
Published: September 2019

Objective This study was performed to share our clinical experience and provide treatment strategies for pediatric hand injuries caused by automatic cup-sealing machines in Taiwan. Methods Thirteen pediatric patients with an average age of 3.6 years were included in this retrospective study. Treatment was based on the location and depth of the injury and included full-thickness skin grafts, free or local flaps, and digital replantation. Some patients underwent contracture release during follow-up. Results Thermal crush injuries affected the left hand in five patients and right hand in eight. Four patients with nine amputated fingers were treated by emergent digital replantation, four were treated by skin grafting, one was treated by nail bed repair, one underwent reconstruction with a local reversed dorsal digital and metacarpal island flap, one underwent reconstruction with a fascia graft for extensor tendon repair and pedicled groin flap coverage, and two underwent reconstruction with free anterolateral thigh fasciocutaneous flaps with a vascularized fascia lata graft for dorsal hand defects. All replanted fingers survived. Conclusion Pediatric hand injuries, especially those caused by cup-sealing machines, can be devastating. Aggressive treatments including early reconstruction and rehabilitation should be performed for all pediatric hand injuries to achieve satisfactory functional restoration.
Difference in the incidence of cerebrospinal fluid leakage and residual tumors between functional and nonfunctional pituitary adenomas treated by endoscopic transsphenoidal pituitary adenomectomy
Authors: Lee Ching-Yi , Chen Yuan-Chuan , Wang Ying-Piao , Chen Shiu-Jau 
Published: September 2019

Objective This study compared the incidence of cerebrospinal fluid (CSF) leakage and residual tumors between functional and nonfunctional pituitary adenomas treated with the endoscopic endonasal transsphenoidal approach (EETA). Methods All patients underwent endocrine examinations and brain magnetic resonance imaging before and after surgery. The length of admission, incidence of central diabetes insipidus, incidence of CSF leakage, symptom relief, and presence of residual tumors were compared between patients with functional and nonfunctional pituitary adenomas. Results Thirty-eight patients were enrolled, among whom 12 and 26 had functional and nonfunctional pituitary adenomas, respectively. The incidence of CSF leakage was significantly higher in patients with nonfunctional adenomas; a hard or elastic tumor character accounted for the difference. A large tumor size and cavernous sinus invasion were risk factors for residual tumors. No significant differences were found in sex, length of admission, operative times, incidence of diabetes insipidus, or number of residual tumors between the two groups. The hormone levels were lower postoperatively than preoperatively in patients with nonfunctional adenomas. Conclusion Nonfunctional pituitary macroadenomas resulted in more CSF leakage. Use of the rescue nasoseptal flap reduced unnecessary nasal destruction. Cooperation between a neurosurgeon and otolaryngologist was safer and more effective when using the EETA.
Two heterozygous mutations in the ERCC6 gene associated with Cockayne syndrome in a Chinese patient
Authors: Zhang Qin , Liu Minjuan , Liu Yinghua , Tang Hui , Wang Ting , Li Hong , Xiang Jingjing 
Published: September 2019

Objective To confirm diagnosis and explore the genetic aetiology in a Chinese patient suspected to have Cockayne syndrome (CS). Methods The patient was clinically examined, and the patient and her biological parents underwent genetic analysis using whole exome sequencing (WES) and Sanger sequencing. The foetus of the patient’s mother underwent prenatal diagnostic Sanger sequencing using amniotic fluid obtained at 19 weeks’ gestation. Results Clinical examination of the patient showed developmental delay, progressive neurologic dysfunction and premature aging. Two compound, heterozygous ERCC excision repair 6, chromatin remodelling factor ( ERCC6) gene mutations were detected in the proband by WES and confirmed by Sanger sequencing, comprising a known paternal nonsense mutation (c.643G > T, p.E215X) and a novel maternal short insertion and deletion mutation (c.1614_c.1616delGACinsAAACGTCTT, p.K538_T539delinsKNVF). The patient was consequently diagnosed with CS type I. The foetus of the patient’s mother was found to carry only the maternally-derived c.1614_c.1616delGACinsAAACGTCTT variant. Conclusion This study emphasized the value of WES in clinical diagnosis, and enriched the known spectrum of ERCC6 gene mutations.
Psychotherapies for Adolescents with Subclinical and Borderline Personality Disorder: A Systematic Review and Meta-Analysis
Authors: Wong Jennifer , Bahji Anees , Khalid-Khan Sarosh 
Published: September 2019

Background: Evidence regarding the efficacy of psychotherapy in adolescents with borderline personality disorder (BPD) symptomatology has not been previously synthesized. Objective: To conduct a systematic review and meta-analysis of the randomized controlled trials (RCTs) in order to assess the efficacy of psychotherapies in adolescents with BPD symptomatology. Methods: Seven electronic databases were systematically searched using the search terms BPD, adolescent, and psychotherapy from database inception to July 2019. Titles/abstracts and full-texts were screened by one reviewer; discrepancies were resolved via consensus. We extracted data on BPD symptomatology, including BPD symptoms, suicide attempts, nonsuicidal self-injury, general psychopathology, functional recovery, and treatment retention. Data were pooled using random-effects models. Results: Of 536 papers, seven trials (643 participants) were eligible. Psychotherapy led to significant short-term improvements in BPD symptomatology posttreatment ( g = −0.89 [−1.75, −0.02]) but not in follow-up ( g = 0.06 [−0.26, 0.39]). There was no significant difference in treatment retention between the experimental and control groups overall (odds ratio [ OR] 1.02, 95% confidence interval [CI], 0.92 to 1.12, I 2 = 52%). Psychotherapy reduced the frequency of nonsuicidal self-injury ( OR = 0.34, 95% CI, 0.16 to 0.74) but not suicide attempts ( OR = 1.03, 95% CI, 0.46 to 2.30). Conclusions: There is a growing variety of psychotherapeutic interventions for adolescents with BPD symptomatology that appears feasible and effective in the short term, but efficacy is not retained in follow-up—particularly for frequency of suicide attempts.
“Down with 1989!”: The Peculiar Right-Wing Backlash against 1968 in Poland
Authors: Ost David 
Published: September 2019

This article is part of the special cluster titled Generation ’68 in Poland (with a Czechoslovak Comparative Perspective). Whereas much of the European right greeted the fiftieth anniversary of 1968 with a critique of its legacy, Poland’s ruling Law and Justice party was largely silent, both because 1968 did not usher in a counterculture and because the protests were directed against the communist party. And yet the Law and Justice party detests the legacy of 1968, for three reasons: 1968 was shaped by the left, ’68 activists and their values played a key role in the ensuing opposition, and because the right actually sympathizes with the communists of 1968, then dominated by nationalists. The right thus traditionally attacks the legacy of 1968 by attacking 1989 instead, when ’68’ ers played a central role and new left progressivism could finally emerge. That began changing early in 2018 when Poland’s parliament passed its Holocaust-speech law banning calumny against the “Polish Nation.” The resulting criticism brought 1968 back with a vengeance, with the right openly inhabiting the role of the national-communists, and beginning to attack Poland’s 1968 directly. Shedding new light on the diverse meanings of 1968 and the relationship of the right to national communism, the piece ends by looking at developments through Bernhard and Kubik’s theory of the politics of memory.
Secondary prevention and cardiovascular care across Europe: A survey of European Society of Cardiology members’ views
Authors: Fitzsimons Donna , Stępińska Janina , Kerins Mary , F Piepoli Massimo , Hill Loreena , Carson Matthew A , Prescott Eva 
Published: September 2019

Introduction: Secondary prevention of cardiovascular disease is a significant clinical challenge and despite European Society of Cardiology (ESC) Guidelines, evidence confirms sub-optimal patient care. Aim: The aim of this study was to evaluate ESC members’ opinions on the current provision of cardiovascular prevention and rehabilitation services across Europe and explore barriers to guideline implementation. Method: Electronic surveys using a secure web link were sent to members of the ESC in eight purposively selected ESC affiliated countries. Results: A total of 479 professionals completed the survey, of whom 67% were cardiologists, 8.6% general physicians, 8.2% nurses and 16.2% other healthcare professionals. Respondents were predominantly (91%) practising clinicians, generally highly motivated regarding cardiovascular disease prevention, but most reported that secondary prevention in their country was sub-optimal. The main barriers to prevention were lack of available cardiac rehabilitation programmes and long-term follow-up, patients’ disease perception and professional attitudes towards prevention. While knowledge of the prevention guidelines was generally good, practices such as motivational counselling and better educational tools were called for to promote exercise, smoking cessation and for nutritional aspects. Conclusions: The provision of services focusing on the secondary prevention of cardiovascular disease varies greatly across Europe. Furthermore, despite ESC Guidelines and a strong evidence base supporting the efficacy of secondary prevention, the infrastructure and co-ordination of such care is lacking. In addition patient motivation is considered poor and some professionals remain unconvinced about the merits of prevention. The disappointing results outlined in this survey emphasise that improved tools are urgently required to educate both patients and professionals and confirm the priority of cardiovascular prevention internationally.