bluuebunny/crossref_metadata_2025_split huggingface dataset:
Service- and practitioner-level variation in non-consensual dropout from child mental health services
Authors: Edbrooke-Childs Julian , Boehnke Jan R. , Zamperoni Victoria , Calderon Ana , Whale Andy 
Published: September 2019

Abstract
Non-attendance of mental health service appointments is an international problem. In the UK, for example, the estimated cost of non-attendance in child mental health services is over £45 million (US dollar 60.94 million) per annum. The objective of this study was to examine whether there were service- and practitioner-level variation in non-consensual dropout in child mental health services. This was an analysis of routinely collected data. Service-level variation (as services covered different geographic areas) and practitioner-level variation were examined in N = 3622 children (mean age 12.70 years; SD 3.62, 57% female, 50% white or white British) seen by 896 practitioners across 39 services. Overall, 35% of the variation in non-consensual dropout was explained at the service level and 15% at the practitioner level. Children were almost four times more likely to drop out depending on which service they attended (median odds ratio = 3.92) and were two-and-a-half times more likely to drop out depending on which practitioner they saw (median odds ratio = 2.53). These levels of variation were not explained by levels of deprivation in areas covered by services or by children’s demographic and case characteristics. The findings of the present research may suggest that, beyond service-level variation, there is also practitioner-level variation in non-consensual dropout in child mental health services.
Phase II study of capecitabine plus oxaliplatin (CapOX) as adjuvant chemotherapy for locally advanced rectal cancer (CORONA II)
Authors: Hattori Norifumi , Nakayama Goro , Uehara Keisuke , Aiba Toshisada , Ishigure Kiyoshi , Sakamoto Eiji , Tojima Yuichiro , Kanda Mitsuro , Kobayashi Daisuke , Tanaka Chie , Yamada Suguru , Koike Masahiko , Fujiwara Michitaka , Nagino Masato , Kodera Yasuhiro 
Published: September 2019

Abstract

Objective
This multicenter, single-arm phase II study (UMIN000008429) aimed to evaluate the efficacy and safety of capecitabine plus oxaliplatin (CapOX) as postoperative adjuvant chemotherapy for patients with locally advanced rectal cancer.

Methods
Patients with resectable clinical Stage II or III rectal cancer were enrolled to receive eight cycles of CapOX therapy (130 mg/m2 oxaliplatin on day 1 and 2000 mg/m2 oral capecitabine on days 1–14, every 3 weeks) after curative surgical resection. The primary endpoint was 3-year relapse-free survival (RFS) rate, and secondary endpoints were 3-year overall survival (OS) rate, treatment compliance, and safety.

Results
A total of 40 patients (Stage II, 21; Stage III, 19) were enrolled between September 2012 and November 2015 from seven institutions. Thirty-nine patients (97%) received R0 resection, and 32 patients (84%) received postoperative CapOX therapy. The completion rate of all eight cycles of CapOX therapy was 66%. Relative dose intensities were 87% for oxaliplatin and 84% for capecitabine. At a median follow-up period of 46 months, disease recurrence was observed in nine patients, including three with local recurrence. Three-year RFS and OS rates were 75% (95% CI 57–86%) and 96% (95% CI 80–99%), respectively. Frequencies of Grade ≥ 3 hematological and non-hematologic adverse events were 19% and 38%, respectively.

Conclusion
CapOX therapy is feasible as adjuvant chemotherapy for locally advanced rectal cancer.
Moment explosions in the rough Heston model
Authors: Gerhold Stefan , Gerstenecker Christoph , Pinter Arpad 
Published: September 2019

AbstractWe show that the moment explosion time in the rough Heston model, introduced by El Euch and Rosenbaum in 2016, is finite if and only if it is finite for the classical Heston model. Upper and lower bounds for the explosion time are established, as well as an algorithm to compute the explosion time (under some restrictions). We show that the critical moments are finite for all maturities. For negative correlation, we apply our algorithm for the moment explosion time to compute the lower critical moment.
Machine imports, technology adoption, and local spillovers
Authors: Békés Gábor , Harasztosi Péter 
Published: September 2019

AbstractIn developing economies import can be the primary source of adopting new technologies and modern production equipment. Using a uniquely compiled Hungarian firm-level dataset, we investigated whether firms’ decision to import a specific machine is influenced by the local accumulation of experience in that same imported machine. Our results suggested that an additional local importer in the firm’s vicinity increases the probability of importing that particular machine considerably. Distance plays a key mediating role as firms, especially in small cities, learned mostly from neighboring peers. We also found that even within a type of imported machine, the source country of the product matters a great deal. Finally, the extent of spillover effects was found to vary a great deal both with respect to the importing firm as well as the composition of peers. Larger, foreign owned and internationalized firms are the ones that benefit from having importing firms in their vicinity, while small and domestically owned firms could actually be adversely affected by peer effects. Our results could be indicative for policy-makers interested in indirect impact of technology upgrade subsidy programs. We found that such indirect effects do exist. However, they are centered on large to large firm interactions. As smaller sized firms producing for the domestic market do not benefit much from import spillovers, policies aimed at helping such firms may not rely on these indirect effects.
Policy measures to promote mid-summer drainage in paddy fields for a reduction in methane gas emissions: the application of a dynamic, spatial computable general equilibrium model
Authors: Kunimitsu Yoji , Nishimori Motoki 
Published: September 2019

Abstract
Rice production is affected by climate change, while climate change is simultaneously accelerated by methane gas (CH4) emissions from paddy fields. The rice sector must take suitable mitigation measures, such as prolonging mid-summer drainage (MSD) before the rice flowering period. To propose a mitigation policy, this study aims to demonstrate the environmental and economic effects of MSD in Japanese paddy fields by using a dynamic, spatial computable general equilibrium (CGE) model and crop model; the study also considers environmental subsidies with a carbon tax scheme to promote MSD measures. The results demonstrate that climate change under the 8.5 representative concentration pathway (RCP) scenario will reduce rice prices and rice farmers’ nominal income due to bumper harvests until the 2050s. Promoting MSD in paddy fields can prevent a decrease in farmers’ nominal income and effectively reduce CH4 emissions if all farmers adopt this measure. However, some farmers can potentially increase their own yield by avoiding MSD under high rice prices, which would be maintained through other farmers’ participation. A strong motivation exists for some farmers to gain a “free ride,” and an environmental subsidy with a carbon tax can help motivate farmers to adopt MSD. Therefore, the policy mix of prolonging MSD and environmental subsidies can increase all farmers’ incomes by preventing “free rides” and decrease greenhouse gas emissions with a slight decrease in Japan’s GDP.
Hashtag hijacking and crowdsourcing transparency: social media affordances and the governance of farm animal protection
Authors: Rodak Olga 
Published: September 2019

AbstractThe post-war Western world has seen a gradual shift from government to governance, a process that also concerned the issues related to agro-food sustainability, such as food quality, environmental impact, social justice, and farm animal welfare. Scholars believe that social media are a new site that reconfigures relations between various actors involved in the governance of these problems. However, empirical research on this matter remains scarce. This paper fills this gap by examining the case of Februdairy, a Twitter hashtag campaign to promote the British dairy industry, hijacked by animal protection activists. For this case, I employ the relational perspective on technology affordances—as operationalised by Faraj and Azad (in: Leonard et al. (eds), Materiality and organizing. Social interaction in a technological world, Oxford University Press, Oxford, 2012)—to highlight two distinct strategic modes of embracement of social media functionalities by the opposing groups: hashtag hijacking and crowdsourcing transparency. The analysis reveals also that a pre-existing social structure of the agro-food system conditions reconfiguration of social relations by technology in a way that actually strengthens the tendency to govern the issue of farm animal protection with market mechanisms.
Recent large-scale landscape changes, genetic drift and reintroductions characterize the genetic structure of Norwegian wild reindeer
Authors: Kvie Kjersti S. , Heggenes Jan , Bårdsen Bård-Jørgen , Røed Knut H. 
Published: September 2019

AbstractLandscape changes, such as habitat loss and fragmentation, subdivide wild populations, reduce their size, and limit gene flow. These changes may further lead to depletion of genetic variation within populations as well as accelerating differentiation among populations. As a migratory species requiring large living areas, wild reindeer (Rangifer tarandus) is highly vulnerable to human activity. The number and continued presence of wild reindeer have been significantly reduced due to accelerating anthropogenic habitat modifications, as well as displacement in benefit of domesticated herds of the species. As a basis for future management strategies we assess genetic structure and levels of genetic variation in Norwegian wild reindeer by analysing 12 microsatellite loci and the mitochondrial control region in 21 management units with varying population sizes. Overall, both markers showed highly varying levels of genetic variation, with reduced variation in the smaller and more isolated populations. The microsatellite data indicated a relationship between population size and genetic variation. This relationship was positive and linear until a threshold for population size was reached at approximately 1500 reindeer. We found high levels of differentiation among most populations, indicating low levels of gene flow, but only a weak correlation between geographic and genetic distances. Our results imply that the genetic structure of Norwegian wild reindeer is mainly driven by recent colonization history, population size, as well as human-induced landscape fragmentation, restricting gene flow and leading to high levels of genetic drift. To sustain viable populations, conservation strategies should focus on genetic connectivity between populations.
The Spectrum of Repression: Swedish Muslims’ Experiences of Anti-terrorism Measures
Authors: Schclarek Mulinari Leandro 
Published: September 2019

Abstract
In this qualitative study, I examine, through the lens of repression, Swedish Muslims’ experiences of being targeted by authorities in the latter’s attempts to prevent terrorism. In an effort to comprehend the full force of this repression—as coercion in its physical and violent sense, but also in its more subtle and consensual forms—I interweave various Marxist and postcolonial perspectives. The study discusses internal aspects of repression, as well as its external qualities, expanding our understanding of how repression occurs between bodies and within society. I develop the concept of “repressive consent” as a means of grasping situations in which people are influenced to undertake activities against their will. Empirically, the article focuses on experiences of disproportionate security controls and encounters with the Swedish Security Service (Säpo). The material reveals both painful and everyday consequences. For some individuals, becoming a target in the War on Terror may have, as the informants of the study indicate, devastating consequences; for others, it may feel like a friendly chat.
Foreign language skills and employment status of European natives: evidence from Germany, Italy and Spain
Authors: Gazzola Michele , Mazzacani Daniele 
Published: September 2019

AbstractThis article examines the relationship between foreign language skills and the employment status of natives in Germany, Italy and Spain. Using a probit model and data from Eurostat’s Adult Education Survey 2011, this article studies the conditional correlation between knowledge of English and French as foreign languages, and the probability of being employed, comparatively, for men and women. The results reveal that skills in English increase the probability of being employed for men in the three countries, respectively, by 3.4, 4.3 and 5.2%. Knowledge of English increases the probability of being employed for women in Germany and Italy—respectively, by 5.6 and 5.7%—but not in Spain. The results also show that very good skills are associated with a higher probability of being employed than sufficient or good skills. The conditional correlation between knowledge of English and employment status for men is larger in countries where skills in this language are less common among the population, and where the unemployment rate is higher. This is consistent with the fundamental economic concept of scarcity. Estimates for French are not statistically significant.
On the relevance of double tax treaties
Authors: Petkova Kunka , Stasio Andrzej , Zagler Martin 
Published: September 2019

AbstractThis paper investigates the effects of double tax treaties (DTTs) on foreign direct investment (FDI) after controlling for their relevance in the presence of treaty shopping. DTTs cannot be considered a bilateral issue, but must be viewed as a network. We define tax distance as the cost of channelling corporate income from one country to another and, by considering treaty shopping through intermediate jurisdictions, we calculate the shortest (i.e. the cheapest) distance between any two countries. We show that relevant tax treaties—which reduce the direct tax distance both over domestic law and the entire existing treaty network—will increase FDI by about 18%.
Opening the Woods: Towards a Quantification of Neolithic Clearance Around the Somerset Levels and Moors
Authors: Farrell Michelle , Bunting M. Jane , Sturt Fraser , Grant Michael , Aalbersberg Gerard , Batchelor Rob , Brown Alex , Druce Denise , Hill Tom , Hollinrake Arthur , Jones Julie , Tinsley Heather , Bayliss Alex , Marshall Peter , Richer Suzi , Whittle Alasdair 
Published: September 2019

AbstractEnvironmental reconstructions from pollen records collected within archaeological landscapes have traditionally taken a broadly narrative approach, with few attempts made at hypothesis testing or formal assessment of uncertainty. This disjuncture between the traditional interpretive approach to palynological data and the requirement for detailed, locally specific reconstructions of the landscapes in which people lived has arguably hindered closer integration of palaeoecological and archaeological datasets in recent decades. Here we implement a fundamentally different method for reconstructing past land cover from pollen records to the landscapes of and around the Somerset Levels and Moors—the Multiple Scenario Approach (MSA)—to reconstruct land cover for a series of 200-year timeslices covering the period 4200–2000 cal BC. Modelling of both archaeological and sediment chronologies enables the integration of reconstructed changes in land cover with archaeological evidence of contemporary Neolithic human activity. The MSA reconstructions are presented as a series of land cover maps and as graphs of quantitative measures of woodland clearance tracked over time. Our reconstructions provide a more nuanced understanding of the scale and timing of Neolithic clearance than has previously been available from narrative-based interpretations of pollen data. While the archaeological record tends to promote a view of long-term continuity in terms of the persistent building of wooden structures in the wetlands, our new interpretation of the palynological data contributes a more dynamic and varying narrative. Our case study demonstrates the potential for further integration of archaeological and palynological datasets, enabling us to get closer to the landscapes in which people lived.
The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu5 receptor case study
Authors: Orgován Zoltán , Ferenczy György G. , Keserű György M. 
Published: September 2019

Abstract
Stabilizing unique receptor conformations, allosteric modulators of G-protein coupled receptors (GPCRs) might open novel treatment options due to their new pharmacological action, their enhanced specificity and selectivity in both binding and signaling. Ligand binding occurs at intrahelical allosteric sites and involves significant induced fit effects that include conformational changes in the local protein environment and water networks. Based on the analysis of available crystal structures of metabotropic glutamate receptor 5 (mGlu5) we investigated these effects in the binding of mGlu5 receptor negative allosteric modulators. A large set of retrospective virtual screens revealed that the use of multiple protein structures and the inclusion of selected water molecules improves virtual screening performance compared to conventional docking strategies. The role of water molecules and protein flexibility in ligand binding can be taken into account efficiently by the proposed docking protocol that provided reasonable enrichment of true positives. This protocol is expected to be useful also for identifying intrahelical allosteric modulators for other GPCR targets.
Thermographic examination of prick test reactions with local anesthetic
Authors: Stanev Evgeni , Dencheva Maria , Lyapina Maya , Forghani Payam 
Published: September 2019

Abstract
In allergology, skin diagnostic tests are divided into epicutaneous, cutaneous and intracutaneous. The prick test is one of the cutaneous tests used most often for the diagnosis of hypersensitivity to local anesthetics. In the case of hypersensitivity to the examined anesthetic and reaction to the histamine-containing solution (positive control), inflammation appears with an increase in the local temperature. This warming can be detected objectively with a thermal camera and can be used in the diagnostic process. This study was used to examine the capabilities of the infrared thermography application, in the prick test of both men and women, by comparing temperature changes and the intensity of allergic inflammation in the positive and negative controls in addition with a negative reaction to an allergen. A group of 115 patients—55 male (52%) and 60 female (48%), are included. All are examined for hypersensitivity to Mepivastesin, together with the positive and negative control. Skin temperature changes of the skin were examined with FLIR A320 thermal camera and the FLIR Reporter Professional software 2013—application used to process the thermal camera images and data. The statistical analysis shows a marked temperature difference between men and women. Similarities in temperature values are detected between the negative reactions to dental anesthetic and the negative control. However, the latter substantially differs from the data obtained with the positive control. Results of the research indicate the possible applications of the thermography diagnostics in evaluation of the prick test results.
Is it ever morally permissible to select for deafness in one’s child?
Authors: Wallis Jacqueline Mae 
Published: September 2019

AbstractAs reproductive genetic technologies advance, families have more options to choose what sort of child they want to have. Using preimplantation genetic diagnosis (PGD), for example, allows parents to evaluate several existing embryos before selecting which to implant via in vitro fertilization (IVF). One of the traits PGD can identify is genetic deafness, and hearing embryos are now preferentially selected around the globe using this method. Importantly, some Deaf families desire a deaf child, and PGD–IVF is also an option for them. Selection for genetic deafness, however, encounters widespread disapproval in the hearing community, including mainstream philosophy and bioethics. In this paper I apply Elizabeth Barnes’ value-neutral model of disability as mere-difference to the case of selecting for deafness. I draw on evidence from Deaf Studies and Disability Studies to build an understanding of deafness, the Deaf community, and the circumstances relevant to reproductive choices that may obtain for some Deaf families. Selection for deafness, with deafness understood as mere-difference and valued for its cultural identity, need not necessitate impermissible moral harms. I thus advocate that it is sometimes morally permissible to select for deafness in one’s child.
The Rhetoric and Reality of Anthropomorphism in Artificial Intelligence
Authors: Watson David 
Published: September 2019

AbstractArtificial intelligence (AI) has historically been conceptualized in anthropomorphic terms. Some algorithms deploy biomimetic designs in a deliberate attempt to effect a sort of digital isomorphism of the human brain. Others leverage more general learning strategies that happen to coincide with popular theories of cognitive science and social epistemology. In this paper, I challenge the anthropomorphic credentials of the neural network algorithm, whose similarities to human cognition I argue are vastly overstated and narrowly construed. I submit that three alternative supervised learning methods—namely lasso penalties, bagging, and boosting—offer subtler, more interesting analogies to human reasoning as both an individual and a social phenomenon. Despite the temptation to fall back on anthropomorphic tropes when discussing AI, however, I conclude that such rhetoric is at best misleading and at worst downright dangerous. The impulse to humanize algorithms is an obstacle to properly conceptualizing the ethical challenges posed by emerging technologies.
Characterization of depolarizing channels using two-photon interference
Authors: Amaral G. C. , Temporão G. P. 
Published: September 2019

Abstract
Depolarization is one of the most important sources of error in a quantum communication link that can be introduced by the quantum channel. Even though standard quantum process tomography can, in theory, be applied to characterize this effect, in most real-world implementations depolarization cannot be distinguished from time-varying unitary transformations, especially when the timescales are much shorter than the detectors response time. In this paper, we introduce a method for distinguishing true depolarization from fast polarization rotations by employing Hong–Ou–Mandel interference. It is shown that the results are independent of the timing resolutions of the photodetectors.