bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of Medial Cuneiform Osteotomy to Correction of Longitudinal Arch Collapse in Stage IIb Adult-Acquired Flatfoot Deformity
Authors: Kunas Grace C. , Do Huong T. , Aiyer Amiethab , Deland Jonathan T. , Ellis Scott J. 
Published: April 2018

Background Residual forefoot supination after correcting the hindfoot in stage IIb adult-acquired flatfoot deformity can be addressed with a dorsal opening wedge medial cuneiform (Cotton) osteotomy. The amount of correction is generally judged clinically, and there currently are no preoperative guides that can predict the size of graft needed. The aim of this study was to evaluate the correlation between patient and operative factors and the correction achieved with the Cotton osteotomy. Methods: Seventy-nine feet in 74 patients undergoing Cotton osteotomy as part of flatfoot reconstruction were reviewed retrospectively. Preoperative and minimum 40-week postoperative lateral foot weightbearing radiographs were compared to assess correction of longitudinal arch collapse as measured by 13 radiographic parameters, with particular emphasis on the cuneiform articular angle (CAA). Additional demographic and intraoperative variables analyzed for association with radiographic change included age, gender, body mass index, amounts and graft types of Cotton osteotomy and lateral column lengthening, and amount of medializing calcaneal osteotomy. A multivariate linear regression model was developed for each variable found to be significant in univariate analysis. Results: The Cotton osteotomy graft size was significantly associated with changes in the CAA ( P < .001), calcaneal pitch ( P = .03), lateral talonavicular Cobb angle ( P = .03), and lateral naviculomedial cuneiform Cobb angle ( P = .03). The Cotton graft size was the only factor found to significantly predict a change in the CAA in the final linear regression model ( P < .001, R2 = 0.27), with each millimeter of Cotton corresponding to a 2.1-degree decrease of the CAA. Conclusion: Correction of longitudinal arch collapse, as measured by the CAA, was primarily influenced by the size of the graft used for the Cotton osteotomy in a linear fashion. The preoperative CAA may help surgeons titrate the proper amount of graft placed intraoperatively. Level of Evidence: Level IV, Retrospective Case Series
Cardiac transplantation in a 20-year-old woman with scleroderma
Authors: Schreiber Benjamin E , Parish Victoria , Knight Daniel S , Bell Alexander D , Denton Christopher P , Banner Nicholas , Coghlan Gerry 
Published: April 2018

Purpose: To describe cardiac transplantation in a young woman with juvenile onset diffuse scleroderma and cardiac involvement. Methods: Case report. Results: A young White girl developed anti-topoisomerase-1 positive diffuse scleroderma aged 14 years with myositis. Pulmonary function tests were normal. Skin disease was treated with mycophenolate mofetil 1 g twice daily, methotrexate 7.5 mg weekly and periodic intravenous prostacyclin. When aged 17 years, she developed raised troponin T of 0.207 mcg/L (normal range <0.03) and NTproBNP (155 pmol/L); 6-min walking distance was 341 m, and she had episodes of presyncope with effort. The next year she developed symptomatic ventricular tachycardias and dual-chamber implantable cardioverter-defibrillator was inserted, with further episodes of ventricular tachycardia and one shock delivered. By age 19 years, 6-min walking distance was 125 m. Echocardiography showed ejection fraction of 15%–20% with dilated left ventricle and pericardial effusion. She was treated with intravenous Rituximab. She became breathless while dressing and managed only 118 m in 6 min. She experienced increasing orthopnoea and peripheral oedema and was found to be in a low cardiac output state, requiring treatment with intravenous milrinone to maintain renal function. She underwent orthotopic cardiac transplantation, making an excellent post-operative recovery, and was discharged 16 days later with tacrolimus, mycophenolate mofetil and prednisolone. After 1 year, she was in New York Heart Association functional class I and with normal cardiac function on echocardiography. Conclusion: This case illustrates the severe cardiac involvement that can occur in juvenile onset diffuse cutaneous systemic sclerosis, in which cardiac involvement is the leading cause of death.
Increased Chromogranin A–Positive Hormone-Negative Cells in Chronic Pancreatitis
Authors: Moin Abu Saleh Md , Cory Megan , Choi Jennifer , Ong Allison , Dhawan Sangeeta , Dry Sarah M , Butler Peter C , Rizza Robert A , Butler Alexandra E 
Published: April 2018

AbstractContextChronic pancreatitis (CP) is characterized by inflammation, fibrosis, and a loss of pancreatic acinar cells, which can result in exocrine and eventually endocrine deficiency. Pancreatitis has been reported to induce formation of new endocrine cells (neogenesis) in mice. Our recent data have implicated chromogranin A–positive hormone-negative (CPHN) cells as potential evidence of neogenesis in humans.ObjectiveWe sought to establish if CPHN cells were more abundant in CP in humans.Design, Setting, and ParticipantsWe investigated the frequency and distribution of CPHN cells and the expression of the chemokine C-X-C motif ligand 10 (CXCL10) and its receptor chemokine C-X-C motif receptor 3 in pancreas of nondiabetic subjects with CP.ResultsCPHN cell frequency in islets was increased sevenfold in CP [2.1% ± 0.67% vs 0.35% ± 0.09% CPHN cells in islets, CP vs nonpancreatitis (NP), P &lt; 0.01], as were the CPHN cells found as scattered cells in the exocrine areas (17.4 ± 2.9 vs 4.2 ± 0.6, CP vs NP, P &lt; 0.001). Polyhormonal endocrine cells were also increased in CP (2.7 ± 1.2 vs 0.1 ± 0.04, CP vs NP, % of polyhormonal cells of total endocrine cells, P &lt; 0.01), as was expression of CXCL10 in α and β cells.ConclusionThere is increased islet endogenous expression of the inflammation marker CXCL10 in islets in the setting of nondiabetic CP and an increase in polyhormonal (insulin-glucagon expressing) cells. The increase in CPHN cells in CP, often in a lobular distribution, may indicate foci of attempted endocrine cell regeneration.
Identification of Differential Transcriptional Patterns in Primary and Secondary Hyperparathyroidism
Authors: Sadowski Samira Mercedes , Pusztaszeri Marc , Brulhart-Meynet Marie-Claude , Petrenko Volodymyr , De Vito Claudio , Sobel Jonathan , Delucinge-Vivier Céline , Kebebew Electron , Regazzi Romano , Philippe Jacques , Triponez Frédéric , Dibner Charna 
Published: April 2018

Abstract

Context
Hyperparathyroidism is associated with hypercalcemia and the excess of parathyroid hormone secretion; however, the alterations in molecular pattern of functional genes during parathyroid tumorigenesis have not been unraveled. We aimed at establishing transcriptional patterns of normal and pathological parathyroid glands (PGs) in sporadic primary (HPT1) and secondary hyperparathyroidism (HPT2).

Objective
To evaluate dynamic alterations in molecular patterns as a function of the type of PG pathology, a comparative transcript analysis was conducted in subgroups of healthy samples, sporadic HPT1 adenoma and hyperplasia, and HPT2.

Design
Normal, adenomatous, HPT1, and HPT2 hyperplastic PG formalin-fixed paraffin-embedded samples were subjected to NanoString analysis. In silico microRNA (miRNA) analyses and messenger RNA–miRNA network in PG pathologies were conducted. Individual messenger RNA and miRNA levels were assessed in snap-frozen PG samples.

Results
The expression levels of c-MET, MYC, TIMP1, and clock genes NFIL3 and PER1 were significantly altered in HPT1 adenoma compared with normal PG tissue when assessed by NanoString and quantitative reverse transcription polymerase chain reaction. RET was affected in HPT1 hyperplasia, whereas CaSR and VDR transcripts were downregulated in HPT2 hyperplastic PG tissue. CDH1, c-MET, MYC, and CaSR were altered in adenoma compared with hyperplasia. Correlation analyses suggest that c-MET, MYC, and NFIL3 exhibit collective expression level changes associated with HPT1 adenoma development. miRNAs, predicted in silico to target these genes, did not exhibit a clear tendency upon experimental validation.

Conclusions
The presented gene expression analysis provides a differential molecular characterization of PG adenoma and hyperplasia pathologies, advancing our understanding of their etiology.
Cholesterol Metabolism Is Enhanced in the Liver and Brain of Children With Citrin Deficiency
Authors: Hirayama Satoshi , Nagasaka Hironori , Honda Akira , Komatsu Haruki , Kodama Takahiro , Inui Ayano , Morioka Ichiro , Kaji Shunsaku , Ueno Tsuyoshi , Ihara Kenji , Yagi Mariko , Kizaki Zenro , Bessho Kazuhiko , Kondou Hiroki , Yorifuji Tohru , Tsukahara Hirokazu , Iijima Kazumoto , Miida Takashi 
Published: April 2018

AbstractContextCitrin-deficient infants present neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD), which resolves at 12 months. Thereafter, they have normal liver function associated with hypercholesterolemia, and a preference for lipid-rich carbohydrate-restricted diets. However, some develop adult-onset type II citrullinemia, which is associated with metabolic abnormalities.ObjectivesTo identify the causes of hypercholesterolemia in citrin-deficient children post-NICCD.Design and SettingWe determined the concentrations of sterol markers of cholesterol synthesis, absorption, and catabolism by liquid chromatography–electrospray ionization–tandem mass spectrometry and evaluated serum lipoprotein profiles.SubjectsTwenty citrin-deficient children aged 5 to 13 years and 37 age-matched healthy children.InterventionNone.Main Outcome MeasuresRelationship between serum lipoproteins and sterol markers of cholesterol metabolism.ResultsThe citrin-deficient group had a significantly higher high-density lipoprotein cholesterol (HDL-C) concentration than did the control group (78 ± 11 mg/dL vs 62 ± 14 mg/dL, P &lt; 0.001), whereas the two groups had similar low-density lipoprotein cholesterol and triglyceride concentrations. The concentrations of markers of cholesterol synthesis (lathosterol and 7-dehydrocholesterol) and bile acids synthesis (7α-hydroxycholesterol and 27-hydroxycholesterol) were 1.5- to 2.8-fold and 1.5- to 3.9-fold, respectively, higher in the citrin-deficient group than in the control group. The concentration of 24S-hydroxycholesterol, a marker of cholesterol catabolism in the brain, was 2.5-fold higher in the citrin-deficient group. In both groups, the HDL-C concentration was significantly positively correlated with that of 27-hydroxycholesterol, the first product of the alternative bile acid synthesis pathway.ConclusionsHDL-C and sterol marker concentrations are elevated in citrin-deficient children post-NICCD. Moreover, cholesterol synthesis and elimination are markedly enhanced in the liver and brain of citrin-deficient children.
Field Junction Technique for Helical Tomotherapy-Based Total Body Irradiation
Authors: Логинова А. , Loginova A. , Товмасян Д. , Tovmasyan D. , Черняев А. , Chernyaev A. , Варзарь С. , Varzar' S. , Кобызева Д. , Kobyzeva D. , Нечеснюк А. , Nechesnyuk A. 
Published: April 2018

Purpose: Combination of total body irradiation (TBI) with chemotherapy is widely used technique for conditioning before hematopoietic stem cell transplantation for patient with hematological malignancies worldwide. Total body irradiation for patients with high height has to be divided into two parts: irradiation of upper part of the patient’s body (including head, body and part of legs) and irradiation of lower part of the patient’s body (including leg). There is an area in which the fields overlap each other – the junction area. The aim of this work is the development and verification of simple junction technique that would provide the dose distribution in the junction area from 90 to 125 % of prescribed dose.
Material and methods: Total body irradiation was performed on the Tomotherapy machine using helical geometry of the beam delivery. Distribution of the dose in junction area was investigated. Simple solution was proposed: during the optimization of the radiotherapy plan certain margin should be maintained between upper and lower targets while dose distribution in junction area satisfies the uniformity requirements for the given irradiation geometry. The dimension of the margin was determined experimentally using a CheesePhantom and radiochromic EBT-2 films. The uniformity of dose distribution in the junction area was monitored by in vivo measurements using radiochromic EBT-2 films located on the skin surface of patients.
Results: The dimension of the margin at which the dose in the junction area is within the range of 90 to 125 % of the prescribed dose was determined experimentally and amounted to 5.25 cm. The values of the measured dose were in the range from 97 to 105 %. In total 18 in vivo measurements of the junction area were performed. According to the results of in vivo dosimetry, the values of the doses measured in the junction area were in the range from 93 ± 3 % to 108 ± 4 %.
Conclusion:The developed planning method with the selected plan geometry ensures satisfactory heterogeneity of the dose distribution in the area of field junction between the upper and lower irradiation regions, despite of the existing uncertainty of patient positioning. Results were confirmed by in vivo measurements. The obtained data can be used for total body irradiation of the patients using Helical Tomotherapy.
EVALUASI KINERJA FILTER CEPAT DI PDAM SIDOARJO DENGAN METODA FILTER CORING
Authors: Marsono Bowo Djoko 
Published: April 2018

Filter air mampu memisahkan kotoran dengan proses fisik, kimia dan biologis melalui media filter. Kualitas air yang akan didistribusi bergantung pada kinerja filter yang digunakan. Untuk itu, diperlukan evaluasi terhadap kinerja filter untuk memberikan gambaran filter saat beroperasi maupun saat backwash. Evaluasi kinerja filter cepat meliputi parameter kekeruhan filtrat, filter run volume, lama operasi filter, dan rasio volume air backwash terhadap volume air filtrat. Evaluasi backwash meliputi parameter profil kekeruhan air cucian backwash, profil kekeruhan filtrat, solid retention profile, dan ukuran media terekspansi pada saat backwash. Evaluasi backwash dilakukan dengan menggunakan metoda filter coring. Penelitian ini dilaksanakan di Instalasi Pengolahan Air Minum Taman Tirta PDAM Sidoarjo, khususnya unit filtrasi, dengan parameter kualitas air yang diperiksa adalah kekeruhan. Hasil penelitian menunjukkan bahwa kinerja filter cepat yang dievaluasi mempunyai rasio volume air backwash terhadap filtrat yang dihasilkan mencapai 2,3% atau dalam katagori baik, filter run volume mencapai 237 - 271 m3/m2 sesuai kriteria. Hasil analisa floc retention sampling dari 2 unit filter yang diteliti mencapai kekeruhan 35 - 44 NTU atau sesuai kriteria floc retention yang berarti media filter bersih. Sedangkan ekspansi media filter terdistribusi dengan baik.
KINERJA PREFILTER SINTETIS
Authors: Marsono Bowo Djoko 
Published: April 2018

Prefilter merupakan salah satu solusi untuk mengurangi beban saringan pasir cepat pada pengolahan air minum. Prefilter dapat diterapkan pada instalasi pengolahan air minum yaitu di bak sedimentasi atau sebelum unit filter. Media sintetis berupa botol plastik bekas dan media dari pabrikan perlu diteliti sebagai media pre filter. Penelitian ini bertujuan untuk mengetahui kinerja prefilter dalam menurunkan tingkat kekeruhan setelah unit sedimentasi. Parameter kinerja terutama diukur dari tingkat efisiensi removal kekeruhan dan headloss yang melewati media prefilter. Penelitian ini menggunakan 3 jenis variabel yaitu jenis media, ketebalan media, dan kecepatan filtrasi. Jenis media yang digunakan adalah media plastik PET dan media fabrikasi. Ketebalan media yang digunakan adalah 6 cm dan 10 cm, sedangkan kecepatan filtrasinya yaitu 6, 8 dan 10 m3/m2/jam dengan konsep aliran kontinyu upflow. Hasil dari penelitian ini menunjukkan bahwa kinerja prefilter terbukti cukup signifikan yaitu dapat mencapai efisiensi penurunan kekeruhan sebesar 44,3% sehingga apabila diterapkan dalam sistem pengolahan air minum dapat meningkatkan produksi filtrat. Kehilangan tekanan selama lima jam operasi, dengan ketebalan 10 cm hanya mencapai 4,2 mm, sangat layak untuk diterapkan di unit clarifier atau sebelum unit filter. Media pabrikan lebih layak diterapkan daripada media plastik ditinjau dari aspek efisiensi penurunan kekeruhan dan kemudahan pemasangan.
Improving the quality and speed of access to operation notes
Authors: Howard Matthew , Parwaiz Hammad , Cassels Emily , Smith Natalie , Howard Lucy 
Published: April 2018

Introduction: Operation notes are often poorly completed, potentially compromising patient care. This project was undertaken to improve the quantity, quality and clarity of information included in operation notes, and make them easier to locate within a set of patient notes. Methods: Operation notes were audited against standards laid out in national guidelines. The time taken for staff to locate an operation note, and information within it, was then measured. The layout was re-designed, followed by a re-audit. Results: The number of operation notes with all measured domains completed rose from 4% to 34% (P<0.001). The mean time to locate the operation note fell from 30 to 4 seconds, and the mean time to locate all requested pieces of information within the operation note fell from 35 to 20 seconds. Conclusions: The interventions have improved quality and speed of access of operation notes, but there is still room for improvement.
Hodnocení kvality terénních programů digitální interpretace přírodního dědictví
Authors: Činčera Jan , Medek Michal , Lupač Miroslav 
Published: April 2018

Studie diskutuje otázku kvality terénní digitální interpretace přírodního dědictví. Popisuje proces vymezení kategorií kvality, který zahrnoval kombinaci literární rešerše, diskuse s experty v rámci ohniskové skupiny a terénní průzkum. V poslední části představuje a diskutuje klíčové kategorie kvality, které by se mohly stát doporučením pro další autory digitální interpretace.
Continuous space-time transformations
Authors: Pazzis Clément de Seguins , Šemrl Peter 
Published: April 2018

Abstract
We prove that every continuous map acting on the four-dimensional Minkowski space and preserving light cones in one direction only is either a Poincaré similarity, that is, a product of a Lorentz transformation and a dilation, or it is of a very special degenerate form.
Adaptation of cardiovascular system stent implants
Authors: Ostasevicius Vytautas , Tretsyakou-Savich Yahor , Venslauskas Mantas , Bertasiene Agne , Minchenya Vladimir , Chernoglaz Pavel 
Published: April 2018

Abstract
Time-consuming design and manufacturing processes are a serious disadvantage when adapting human cardiovascular implants as they cause unacceptable delays after the decision to intervene surgically has been made. An ideal cardiovascular implant should have a broad range of characteristics such as strength, viscoelasticity and blood compatibility. The present research proposes the sequence of the geometrical adaptation procedures and presents their results. The adaptation starts from the identification of a person’s current health status while performing abdominal aortic aneurysm (AAA) imaging, which is a point of departure for the mathematical model of a cardiovascular implant. The computerized tomography scan shows the patient-specific geometry parameters of AAA and helps to create a model using COMSOL Multiphysics software. The initial parameters for flow simulation are taken from the results of a patient survey. The simulation results allow choosing the available shape of an implant which ensures a non-turbulent flow. These parameters are essential for the design and manufacturing of an implant prototype which should be tested experimentally for the assurance that the mathematical model is adequate to a physical one. The article gives a focused description of competences and means that are necessary to achieve the shortest possible preparation of the adapted cardiovascular implant for the surgery.
Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19
Authors: Schrul Bianca , Schliebs Wolfgang 
Published: April 2018

Abstract
In order to adapt to environmental changes, such as nutrient availability, cells have to orchestrate multiple metabolic pathways, which are catalyzed in distinct specialized organelles. Lipid droplets (LDs) and peroxisomes are both endoplasmic reticulum (ER)-derived organelles that fulfill complementary functions in lipid metabolism: Upon nutrient supply, LDs store metabolic energy in the form of neutral lipids and, when energy is needed, supply fatty acids for oxidation in peroxisomes and mitochondria. How these organelles communicate with each other for a concerted metabolic output remains a central question. Here, we summarize recent insights into the biogenesis and function of LDs and peroxisomes with emphasis on the role of PEX19 in these processes.
Analysis and Calculation of the Fluid Flow and the Temperature Field by Finite Element Modeling
Authors: Dhamodaran M. , Jegadeesan S. , Kumar R. Praveen 
Published: April 2018

Abstract
This paper presents a fundamental and accurate approach to study numerical analysis of fluid flow and heat transfer inside a channel. In this study, the Finite Element Method is used to analyze the channel, which is divided into small subsections. The small subsections are discretized using higher number of domain elements and the corresponding number of nodes. MATLAB codes are developed to be used in the analysis. Simulation results showed that the analyses of fluid flow and temperature are influenced significantly by the changing entrance velocity. Also, there is an apparent effect on the temperature fields due to the presence of an energy source in the middle of the domain. In this paper, the characteristics of flow analysis and heat analysis in a channel have been investigated.
A Repeated Power Training Enhances Fatigue Resistance While Reducing Intraset Fluctuations
Authors: Gonzalo-Skok Oliver , Tous-Fajardo Julio , Moras Gerard , Arjol-Serrano José Luis , Mendez-Villanueva Alberto 
Published: April 2018

Abstract
Oliver, GS, Julio, TF, Moras, G, José Luis, AS, and Alberto, MV. A repeated power training enhances fatigue resistance while reducing intraset fluctuations. J Strength Cond Res 33(10): 2711–2721, 2019—The present study analyzed the effects of adding upper-body repeated power ability (RPA) training to habitual strength training sessions. Twenty young elite male basketball players were randomly allocated into a control group (CON, n = 10) or repeated power group (RPG, n = 10) and evaluated by 1 repetition maximum (1RM), incremental load, and RPA tests in the bench press exercise before and after a 7-week period and a 4-week cessation period. Repeated power group performed 1–3 blocks of 5 sets of 5 repetitions using the load that maximized power output with 30 seconds and 3 minute of passive recovery between sets and blocks, respectively. Between-group analysis showed substantial greater improvements in RPG compared with CON in: best set (APB), last set (APL), mean power over 5 sets (APM), percentage of decrement, fluctuation decrease during APL and RPA index (APLpost/APBpre) during the RPA test (effect size [ES] = 0.64–1.86), and 1RM (ES = 0.48) and average power at 80% of 1RM (ES = 1.11) in the incremental load test. The improvements of APB and APM were almost perfectly correlated. In conclusion, RPA training represents an effective method to mainly improve fatigue resistance together with the novel finding of a better consistency in performance (measured as reduced intraset power fluctuations) at the end of a dynamic repeated effort.