bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the influence of feedback given by people with lived experience of mental distress on learning for preregistration mental health students
Authors: Stacey Gemma , Pearson Mark 
Published: May 2018

Accessible summaryWhat is known on the subject?

The involvement of those with lived experience is broadly understood to be beneficial to student learning.

The consequence of the process and implications for learning are predominantly unexplored.

What the paper adds to existing knowledge?

The paper explores an innovative co‐produced model of involving people with lived experience in the assessment process of mental health nursing students.

This method of assessment enables students to further critically analyze the application of humanistic skills and theories of person‐centred care.

What are the implications for practice?

The involvement of people with lived experience in the assessment process of students promotes self‐awareness and empathy.

It is questionable if learning which is potentially troublesome should act as a form of academic assessment which is exposed to the external judgement of another and awarded a credit‐bearing grade.

AbstractIntroductionDespite a positive and established perception of people with lived experience of mental distress contributing to the assessment of healthcare professionals, the consequence and implications for learning are predominantly unexplored.AimTo gain a greater understanding of the influence of feedback given by people with lived experience, in the role of formative assessor, on student learning.MethodQualitative analysis, underpinned by the theory threshold concepts, was conducted on the written reflective assessments, submitted by students, following engaging in an assessment with a lived experience assessor.ResultsStudent learning was influenced positively by the involvement of lived experience assessors in relation to person‐centred care. However, students reported the experience to be anxiety provoking due to the desire to seek external approval and conceal personal challenges.DiscussionThe results indicate that the feedback from those with lived experience promotes greater self‐awareness and empathy amongst students. The perceived expectation to present a competent and professional performance acts as a barrier to authentic person‐centred practice.Implications for practiceIt is questionable if learning which is potentially troublesome should act as a form of academic assessment, which is exposed to the external judgement of another and awarded a credit‐bearing grade.
Developmental and social constraints on early reproduction in an asocial ground squirrel
Authors: Wells C. P. , Van Vuren D. H. 
Published: May 2018

AbstractFor short‐lived species, selection for early reproduction should be strong, yet females often delay their first reproductive bout. Delay in age of first reproduction due to developmental constraints, such as food availability, or social constraints, such as the inhibitory presence of breeding adults, has been documented for social mammals, but effects on asocial species are less well known. We evaluated the influence of developmental and social factors on early reproduction in a short‐lived, asocial species, the golden‐mantled ground squirrel (Callospermophilus lateralis). We found that females who reproduced as yearlings had been weaned earlier in their natal summer and experienced early snow melt during their yearling spring, suggesting the importance of access to high‐quality food at critical stages. Females were more likely to reproduce as yearlings when there were more adult males present during the breeding season, possibly because exposure to males accelerates reproductive maturity. Maternal presence had no effect on yearling reproduction, but yearlings with a littermate sister present were only 22% as likely to reproduce as females without a sister present, suggesting the effect of sibling competition well past weaning. Furthermore, the negative effect of a sister's presence, but not the presence of other females, suggests that relatedness affects reproductive competition in this asocial species.
Old Janus drinking from his guampa: A Brazilian re‐creation of The Canterbury Tales
Authors: Botelho José Francisco 
Published: May 2018

AbstractThis article explains the circumstances that shaped, and the strategies that guided, my translation of The Canterbury Tales into Brazilian Portuguese. This first complete and versified translation of Geoffrey Chaucer's The Canterbury Tales aims to re‐create the aesthetic, poetic, and narrative power of the original, in order to give it new life in the context of Brazilian culture and, more broadly, of contemporary South American culture. The article describes the methods used during the translation to create a fictional Middle Ages, in which Brazilian readers of the twenty‐first century could find a measure of familiarity and strangeness. To do so, the translation incorporates dictions inspired by rural Brazilian culture and popular oral poetry. At the same time, these dictions connect with the cultures of neighboring countries, such as Argentina and Uruguay. The article demonstrates how words, images, and poetic forms extracted from the universe of rural popular culture were used in crucial passages of the Tales, in order to create a veritable fictional universe, based on the idea that the translation of a classic is not only the recreating of a past text but also a way to echo other voices.
A Customized Hybrid Approach to Infrastructure Maintenance Scheduling in Railroad Networks under Variable Productivities
Authors: Xie Siyang , Lei Chao , Ouyang Yanfeng 
Published: May 2018

AbstractRailroads are maintained routinely by using various types of rail‐bound machines so as to achieve the longest possible rail life and reduce the safety risks associated with unanticipated rail failures. The rail maintenance routing and scheduling problem (RMRSP), which involves routing of multiple maintenance vehicles and scheduling of hundreds of maintenance jobs over a large‐scale network, is usually subject to various types of complex constraints and extremely difficult to solve. This article proposes a vehicle routing problem with time windows (VRPTW) formulation for RMRSP and develops a customized stepwise algorithm to solve the problem. A series of numerical experiments are conducted to demonstrate that the proposed algorithm works very effectively, significantly outperforming the state‐of‐the‐art commercial solver. The results of two real‐world instances from a Class I railroad company show that the proposed model and solution algorithm enable the expensive maintenance vehicles to achieve a higher level of utilization, that is, spending more time on working and less time on deadhead traveling.
The core effector Cce1 is required for early infection of maize by Ustilago maydis
Authors: Seitner Denise , Uhse Simon , Gallei Michelle , Djamei Armin 
Published: May 2018

AbstractThe biotrophic pathogen Ustilago maydis, the causative agent of corn smut disease, infects one of the most important crops worldwide – Zea mays. To successfully colonize its host, U. maydis secretes proteins, known as effectors, that suppress plant defense responses and facilitate the establishment of biotrophy. In this work, we describe the U. maydis effector protein Cce1. Cce1 is essential for virulence and is upregulated during infection. Through microscopic analysis and in vitro assays, we show that Cce1 is secreted from hyphae during filamentous growth of the fungus. Strikingly, Δcce1 mutants are blocked at early stages of infection and induce callose deposition as a plant defense response. Cce1 is highly conserved among smut fungi and the Ustilago bromivora ortholog complemented the virulence defect of the SG200Δcce1 deletion strain. These data indicate that Cce1 is a core effector with apoplastic localization that is essential for U. maydis to infect its host.
What makes working memory traces stable over time?
Authors: Jarjat Gabriel , Hoareau Violette , Plancher Gaën , Hot Pascal , Lemaire Benoît , Portrat Sophie 
Published: May 2018

AbstractUnderstanding the factors that make working memory (WM) traces stable over time is important because WM is the keystone of general cognitive achievement. Two views of attentional WM maintenance have been suggested to account for the long‐term retention of WM information. First, the distractors in a WM task are thought to foster the creation of episodic memory cues through covert retrieval. Second, the cognitive load (CL) of the distractors is thought to vary long‐term memory instantiation. In this study, we propose an additional parsimonious perspective: the total time during which each trace is under the control of attention in WM is the key to long‐term retention. Participants performed a complex span task in which the CL and number of distractors were orthogonally manipulated, and thereafter the participants performed a delayed recall test. Similar to previous findings, the results showed effects of the number of distractors and of CL on delayed recall. Our results went further, however, by showing a non‐linear relationship between delayed recall performance and the free time accumulated between encoding and immediate recall. The role of time in episodic memory performance and the underlying WM maintenance mechanism are discussed.
Managing medications for individuals living with a dementia: Evaluating a web‐based information resource for informal carers
Authors: Horne Frances , Burns Pippa , Traynor Victoria , Gillespie Robyn , Mullan Judy , Baker Amanda , Harrison Lindsey , Win Khin Than 
Published: May 2018

AimsThe purpose of the study was to evaluate the usefulness of the “Managing Medicines for People with Dementia” (www.dementiameds.com) website for informal carers.BackgroundThe management of medications for individuals living with a dementia by informal carers is a neglected area of care. We know that informal carers find it difficult accessing reliable and comprehensive information about medications. We also know that the Internet is a contemporary and growing medium through which consumers access health information. This study was unique in that it brought these two elements together through an interdisciplinary study about the usefulness of a new website providing information on medication management.MethodsData collection consisted of focus groups with informal carers of individuals living with a dementia. Data were analysed through content analysis.FindingsFour themes were generated from the data to explain the evaluation of the website by informal carers: (1) Suitability of the website; (2) Presentation of the website; (3) Unexpected benefits of the website content; (4) Future enhancements for website. Participants overwhelmingly agreed the content of the website filled a gap in information needs about medication management for individuals living with a dementia.Implications for practiceThis qualitative evaluation demonstrated the value of the website as a resource for informal carers of individuals living with a dementia. The resource could also be used by community nurses and other healthcare practitioners to help informal carers better manage the medication regimes of individuals living with a dementia. The resource has the potential to reduce complications associated with mismanagement of medications and contribute to new policies for implementing safe medication practices.
Development of rice (Oryza sativa) lines resistant to aryloxyphenoxypropionate herbicides through induced mutation with gamma rays
Authors: de Andrade Alexander , Tulmann‐Neto Augusto , Tcacenco Fernando A. , Marschalek Rubens , Pereira Adriana , de Oliveira Neto Antonio M. , Scheuermann Klaus K. , Wickert Ester , Noldin José A. 
Published: May 2018

AbstractThe aryloxyphenoxypropionate herbicides (APPs) are graminicides with excellent control of many grass weeds species, including weedy rice (Oryza sativa L.). These herbicides block the fatty acid biosynthesis by inhibiting the enzyme acetyl‐CoA carboxylase (ACCase), resulting in the death of susceptible plants. Inducing mutation with gamma rays to rice seeds, two lines resistant to APPs herbicides were developed. Plant dose–response assays confirmed the resistance to the APPS herbicides quizalofop‐p‐ethyl and haloxyfop‐p‐methyl. The carboxyltransferase domain fragments of ACCase from the resistant biotype and susceptible control were sequenced and compared. A point mutation was detected in the amino acid position 2,027 (Rice Genome Annotation Project: Os05g22940.1). Results indicated that resistance to APPs is a consequence of an altered ACCase enzyme that confers resistance. The use of APPs herbicide‐resistant rice lines represents an innovative and promising alternative for weedy rice control in paddy rice systems.
Influence of drought and heat stress, applied independently or in combination during seed development, on qualitative and quantitative aspects of seeds of lentil (Lens culinarisMedikus) genotypes, differing in drought sensitivity
Authors: Sehgal Akanksha , Sita Kumari , Bhandari Kalpna , Kumar Shiv , Kumar Jitendra , Vara Prasad P.V. , Siddique Kadambot H.M. , Nayyar Harsh 
Published: May 2018

AbstractTerminal droughts, along with high temperatures, are becoming more frequent to strongly influence the seed development in cool‐season pulses like lentil. In the present study, the lentil plants growing outdoors under natural environment were subjected to following treatments at the time of seed filling till maturity: (a) 28/23 °C day/night temperature as controls; (b) drought stressed, plants maintained at 50% field capacity, under the same growth conditions as in a; (c) heat stressed, 33/28 °C day/night temperature, under the same growth conditions as in a; and (d) drought + heat stressed, plants at 50% field capacity, 33/28 °C day/night temperature, under the same growth conditions as in (a). Both heat and drought resulted in marked reduction in the rate and duration of seed filling to decrease the final seed size; drought resulted in more damage than heat stress; combined stresses accentuated the damage to seed starch, storage proteins and their fractions, minerals, and several amino acids. Comparison of a drought‐tolerant and a drought‐sensitive genotype indicated the former type showed significantly less damage to various components of seeds, under drought as well as heat stress suggesting a cross tolerance, which was linked to its (drought tolerant) better capacity to retain more water in leaves and hence more photo‐assimilation ability, compared with drought‐sensitive genotype.
Hematopoietic stem cell transplantation without in vivo T‐cell depletion for pediatric aplastic anemia: A single‐center experience
Authors: Li Sidan , Wang Bin , Fu Lingling , Pang Yilin , Zhu Guanghua , Zhou Xuan , Ma Jie , Su Yan , Qin Maoquan , Wu Runhui 
Published: May 2018

AbstractFor young patients, HLA‐MRD HSCT is the first‐line treatment of SAA. However, due to China's birth control policy, few patients could find suitable sibling donors and HLA‐MUD. More and more transplantation centers have used Haplo‐D as the donor source for young adult and pediatric patients. However, studies with larger amount of pediatric patients are rare. We retrospectively analyzed the data of children with AA who were treated with allogeneic HSCT and compared the therapeutic efficacy of Haplo‐HSCT and MRD/MUD group. A total of 62 patients were enrolled. Implantation was successfully performed in 58 patients. There was no significant difference in the time for reconstruction of hematopoietic function between patients in the two groups. Thirty‐two had grade I‐IV aGVHD with incidence of 51.61%. The incidence of aGVHD was 79.41% for patients in the Haplo‐HSCT, significantly higher than that of 17.86% for patients in the MRD/MUD group (P < .01). However, the incidence of cGVHD was not significantly different between patients in the two groups (26.47% vs 10.71%, P = .09), the incidence of CMV infection was 28.57% and 52.94% for patients in the MRD/MUD and Haplo group, respectively, showing no significant difference (P = .053). The incidence of EBV infection was 47.06% for patients in the Haplo group and 28.57% for patients in the MRD/MUD group, showing no significant difference (P = .11). However, the 3‐ and 5‐year cumulative OS and FFS rates showed statistically significant difference in the two groups, P = .012 and .045, respectively. Compared to Haplo‐HSCT, MRD/MUD is more economic. In this study, we achieved good Haplo transplantation results. The incidences of cGVHD and CMV/EBV were not significantly different between Haplo group and MRD/MUD group. Although OS and FFS of the Haplo group were not as good as those of the MRD/MUD group, it is still acceptable as an alternative treatment under emergency.
The floral homeotic protein SEPALLATA3 recognizes target DNA sequences by shape readout involving a conserved arginine residue in the MADS‐domain
Authors: Käppel Sandra , Melzer Rainer , Rümpler Florian , Gafert Christian , Theißen Günter 
Published: May 2018

SummarySEPALLATA3 of Arabidopsis thaliana is a MADS‐domain transcription factor (TF) and a key regulator of flower development. MADS‐domain proteins bind to sequences termed ‘CArG‐boxes’ [consensus 5′‐CC(A/T)6GG‐3′]. Because only a fraction of the CArG‐boxes in the Arabidopsis genome are bound by SEPALLATA3, more elaborate principles have to be discovered to better understand which features turn CArG‐boxes into genuine recognition sites. Here, we investigate to what extent the shape of the DNA is involved in a ‘shape readout’ that contributes to the binding of SEPALLATA3. We determined in vitro binding affinities of SEPALLATA3 to DNA probes that all contain the CArG‐box motif, but differ in their predicted DNA shape. We found that binding affinity correlates well with a narrow minor groove of the DNA. Substitution of canonical bases with non‐standard bases supports the hypothesis of minor groove shape readout by SEPALLATA3. Analysis of mutant SEPALLATA3 proteins further revealed that a highly conserved arginine residue, which is expected to contact the DNA minor groove, contributes significantly to the shape readout. Our studies show that the specific recognition of cis‐regulatory elements by a plant MADS‐domain TF, and by inference probably also of other TFs of this type, heavily depends on shape readout mechanisms.
Monetary union in West Africa and business cycles synchronicity: New evidence
Authors: Simons Daniel , Jean Louis Rosmy 
Published: May 2018

AbstractIn the light of the initiative of the West African Monetary Zone (WAMZ) to introduce a common currency by 2020, this paper investigates the intricacies of the business cycles synchronicity among the six countries. Given: (i) the rising importance of trade and cooperation with China; (ii) the consideration of the Euro as a potential anchor currency and a vehicle for trade with the Eurozone; and (iii) the importance of Nigeria as the largest country of the group and the main supplier of oil, we investigate the relative importance of these three major players in having their business cycles linked with the group. In addition, we investigate the underlying determinants of the business cycles synchronicity among the WAMZ countries on a pairwise basis. Results show a clear dominance of China's business cycle synchronicity with the WAMZ over Europe's and Nigeria's. Trade integration emerges as the key underlying factor of the common cycle observed.
Training, Performance, and Physiological Predictors of a Successful Elite Senior Career in Junior Competitive Road Cyclists
Authors: Svendsen Ida S. , Tønnesen Espen , Tjelta Leif Inge , Ørn Stein 
Published: May 2018

Purpose: To determine whether training, performance, or physiological variables at age 18 can predict which athletes become World Tour (WT) riders at senior level. Methods: Based on performance level at age 23, 80 competitive male cyclists were retrospectively categorized into 4 groups: retired (n = 21), club (n = 26), continental (n = 24), or WT (n = 9). Data collected at age 18 were analyzed to determine whether training, performance, or physiological variables differed significantly between groups. Results: At age 23, 9 riders (11%) were WT level. These riders competed significantly more at age 18 than athletes who were club level (91.5 [19.1] h vs 62.8 [21.8] h, P = .032) or retired by age 23 (61.8 [23.4] h, P = .014). WT athletes placed significantly better in national road championships at age 18 than did continental, club, and retired athletes (all P < .01). Receiver-operating-characteristic analysis showed that placing at national championships at age 18 had good accuracy in predicting whether the athlete would later reach WT level (area under the curve = 0.882). WT athletes had significantly higher maximal aerobic power at age 18 than athletes who did not reach WT level (533 [23] vs 451 [41] W and 6.9 [0.4] vs 6.2 [0.4] W/kg, P < .05). Conclusion: Already at junior level, there were performance and physiological differences distinguishing those who later became WT riders. The findings emphasize the need for high volumes of training and competition, as well as a high level of race performance already at junior level, to become a successful elite road cyclist.
Pharmacokinetics and Safety Profile of Artesunate-Amodiaquine Coadministered with Antiretroviral Therapy in Malaria-Uninfected HIV-Positive Malawian Adults
Authors: Banda Clifford G. , Dzinjalamala Fraction , Mukaka Mavuto , Mallewa Jane , Maiden Victor , Terlouw Dianne J. , Lalloo David G. , Khoo Saye H. , Mwapasa Victor 
Published: May 2018

ABSTRACT

There are limited data on the pharmacokinetic and safety profiles of artesunate-amodiaquine in human immnunodeficiency virus-infected (HIV
+
) individuals receiving antiretroviral therapy. In a two-step intensive sampling pharmacokinetic trial, we compared the area under the concentration-time curve from 0 to 28 days (AUC
0–28
) of an active metabolite of amodiaquine, desethylamodiaquine, and treatment-emergent adverse events between antiretroviral therapy-naive HIV
+
adults and those taking nevirapine and ritonavir-boosted lopinavir-based antiretroviral therapy. In step 1, malaria-uninfected adults (
n
= 6/arm) received half the standard adult treatment regimen of artesunate-amodiaquine. In step 2, another cohort (
n
= 25/arm) received the full regimen. In step 1, there were no safety signals or significant differences in desethylamodiaquine AUC
0–28
among participants in the ritonavir-boosted lopinavir, nevirapine, and antiretroviral therapy-naive arms. In step 2, compared with those in the antiretroviral therapy-naive arm, participants in the ritonavir-boosted lopinavir arm had 51% lower desethylamodiaquine AUC
0–28
, with the following geometric means (95% confidence intervals [CIs]): 23,822 (17,458 to 32,506) versus 48,617 (40,787 to 57,950) ng · h/ml (
P
< 0.001). No significant differences in AUC
0–28
were observed between nevirapine and antiretroviral therapy-naive arms. Treatment-emergent transaminitis was higher in the nevirapine (20% [5/25]) than the antiretroviral therapy-naive (0.0% [0/25]) arm (risk difference, 20% [95% CI, 4.3 to 35.7];
P
= 0.018). The ritonavir-boosted lopinavir antiretroviral regimen was associated with reduced desethylamodiaquine exposure, which may compromise artesunate-amodiaquine's efficacy. Coadministration of nevirapine and artesunate-amodiaquine may be associated with hepatoxicity.