bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Applications of Organocatalysis in Total Synthesis of Natural Products at Room Temperature
Authors: Lohar Sisir , Mitra Piyali , Majhi Sasadhar 
Published: November 2024

Abstract:
Molecules of natural origin play a profound role in drug discovery and development since
natural products derived from Mother Nature, particularly from plants are employed as satisfactory
precursors for important medicines. The total synthesis of complex natural products endures as a
dynamic field of chemical research as the demand for bioactive natural products and secondary metabolites
is gradually enhancing owing to their great application in the area of synthetic organic
chemistry and the biological community. It is very useful in ascertaining the hypothetical complex
structure of such molecules in the laboratory since different biologically potent secondary metabolites
are derived in small quantities frequently. The total synthesis of natural products using organocatalysis
as the key step(s) has earned momentum recently because of high chemical efficiency, low
toxicity, simple accessibility, low cost, and eco-friendly of organocatalysts due to the absence of a
metal atom as well as the popularity of asymmetric catalysis research. This greener strategy is capable
enough to execute the transformations at ambient temperature as per the sixth principle of green
chemistry which is dedicated to the “Design for Energy Efficiency”. Cinchona alkaloids, chiral secondary
and primary amines, guanidine and guanidiniums, N-heterocyclic carbenes, etc. are important
organocatalysts in the field of the total synthesis of natural products and related compounds. Thus,
the present review aims to deal with the total synthesis of natural products at room temperature as
crucial intermediate(s) and it also offers an overview of natural sources, structures, and biological
activities of natural products for the first time modishly.
Deciphering Plasmodium Condensin Core Subunits of Structural Maintenance of Chromosomes 2 (SMC2) as a Putative Drug Target for Antimalarial Drug
Authors: Chauhan Uma , Datta Manali , Kaushik Sanket , Sharma Vinay , Piplani Sakshi , Niraj Ravi Ranjan Kumar 
Published: November 2024

Background:
The structural maintenance of chromosomes (SMC) proteins
plays a noteworthy role in chromosome dynamics. Several recent studies reported that the
condensin core subunits of structural maintenance of chromosomes 2 (SMC2) play important
roles in the atypical mitosis of the Plasmodium life cycle and may perform different
functions during different proliferative stages. For eukaryotes, the structural maintenance
of chromosomes (SMC) proteins are divided into six subunits and form three heterodimers
of structural maintenance of chromosomes (SMC1/3) cohesion complex, structural
maintenance of chromosomes (SMC2/4) condensin complex, and structural maintenance of
chromosomes (SMC5/6) complex for chromosome cohesion, condensation, and DNA
damage repair, respectively.

Objective:
The objective of this study was to investigate the structural maintenance of
chromosomes 2 (SMC2) protein of P. falciparum as a putative drug target of malariacausing
Plasmodium falciparum.

Methods:
In this study, we investigated the structural maintenance of chromosomes 2
(SMC2) protein of P. falciparum as a putative drug target of malaria-causing P. falciparum
by using in-silico approaches like Homology modeling, in-silico evaluation of the modeled
structure, molecular docking study to investigate the interaction of receptor-ligand, and
molecular dynamic simulation study with MM calculation.

Results:
We reported the structural maintenance of chromosomes 2 (SMC2) protein of P.
falciparum as a potent drug target that can pave the way for novel drug discovery to mitigate
malaria.

Conclusion:
In-silico-based studies play a significant role in understanding any protein for
potential drug development.
Feasibility of Sexual Health and Contraceptive Web Services for Adolescents and Young Adults: Retrospective Study of a Pilot Program on Reunion Island
Authors: Reynaud Danielle , Bouscaren Nicolas , Cartron Emmanuelle , Marimoutou Catherine 
Published: November 2024

Abstract

Background
Sexual health indicators for adolescents and young adults (AYAs) aged between 13 and 25 years are particularly poor on Reunion Island. Access to accurate information as well as sexual health and contraceptive services are vital to maintaining sexual well-being. Teleconsultations offer a promising approach to addressing the sexual health and contraceptive needs of AYAs who are more susceptible to engaging in unprotected sexual intercourse. However, the literature on digital sexual health services for this demographic group is limited.

Objective
This study aims to describe the feasibility of a pilot sexual health and contraceptive teleconsultation web service used by AYAs on Reunion Island.

Methods
A descriptive, retrospective study was conducted at the Reunion Island University Hospital Center using a convenient sample. Eligible participants were informed about the program through various communication channels, including seminars for health care professionals, radio broadcasts, posters, flyers, press articles, videos, and social media posts. AYAs accessed a web-based platform named SEXTUOZE from December 15, 2021, to September 30, 2022, that offered sexual health information and teleconsultations. Data collected included participant and teleconsultation characteristics, patient satisfaction, and the quality of completeness of medical records.

Results
A total of 22 teleconsultations were scheduled and 7 were completed, all via synchronous video communication (duration: median 35 min). Overall, 4731 sessions were generated on the SEXTUOZE website. Reasons cited for accessing the web services were to seek sexual health advice (8/22, 36%), receive an initial birth control prescription (12/22, 55%), and inquire about condom prescriptions (2/22, 9%).

Conclusions
While teleconsultation use for sexual health was initially low, it rose toward the end of the study period. Considering all elements of the implementation theory, future research should design interventions that not only are more operative and tailored but also ensure their adoption and sustainability in various health contexts.
The Effect of Total Work-Time Information on a Performance Evaluation Bias against Telecommuting Mothers
Authors: Wang Laura W. , Williamson Michael G. , Yang Li 
Published: November 2024

ABSTRACT
Organizations are increasingly utilizing remote monitoring tools that can track the total time telecommuting employees spend on work activities. We examine whether and how this information can eliminate a specific gender-based bias in the performance evaluations of telecommuting parents. Specifically, managers tend to evaluate telecommuting mothers less favorably than telecommuting fathers when performance outcomes are unfavorable, due to biased effort attribution. The availability of total work-time information can effectively eliminate this bias. Results from our main experiment and four supplemental experiments support our predictions and provide process-level evidence for our theory. Our theory and results suggest that leveraging remote monitoring tools’ capacity to track employees’ total work time can enhance the fairness and effectiveness of performance evaluations for telecommuting mothers.
Ultrasonographic Predication of Gestational Age and Expected Whelping Date in Canine (Canis familiaris)
Authors: Yadav Lakshmi , Sarswat Chander Shekar , Purohit Shivani , Gurjar Kuldeep singh , Yadav Sumit Prakash , Kumar Hitesh 
Published: November 2024

The present study was conducted during August, 2023 to March, 2024 at Veterinary Clinical Complex in department of Veterinary Gynaecology and Obstetrics, Post Graduate Institute of Veterinary Education and Research (PGIVER) Jaipur to study the gestational age during pregnancy in different breeds (Canis familiaris) by using various ultrasonographic parameters such as Gestational Sac Diameter (GSD), Head Diameter (HD), Crown Rump Length (CRL) and Body Diameter (BD) and to also study the expected and actual whelping date in different breeds (Canis familiaris). Using ultrasound, 30 bitches’ pregnancy diagnoses were determined. The bitches were examined during different phases. 11 pregnant bitches were examined during first phase 20 to 30 days’ post mating, 6 pregnant bitches were examined during second phase 30 to 45 days’ post mating and 13 pregnant bitches were examined in third phase 45 to 60 days’ post mating. During first phase Gestational sac diameter was measured, during second phase Crown rump length was measured and during third phase Head diameter and Body diameter were measured. During first phase the mean (±SE) gestational sac diameter was 1.23±0.12 cm. The calculated gestational age by using formula I was found to be 27.4±0.74 days. The difference between expected and actual whelping date during this phase mean (±SE) was -2.36±0.20 days. During the second phase the mean (±SE) CRL measurement was 2.99±0.28 cm. The calculated gestational age by using formula II mean (±SE) found to be 35.96±0.85 days. The difference between expected and actual whelping date during this phase mean (±SE) was -1.5±0.62 days. During the third phase the mean (±SE) BPD was 2.04±0.08 cm and BD was 3.37±0.14 cm. The calculated gestational age by formula III mean (±SE) was 50.57±1.33 days, by formula IV mean (±SE) was 52.59±1.01 days and by formula V mean (±SE) was 52.34±0.88 days. The difference between expected and actual whelping date mean (±SE) was -1.85±0.52 days.
Research on Innovative Design of Intangible Cultural Heritage Integrating Traditional Handicrafts and Modern Information Technology
Authors: Jia Ran , Wang Jiaqi 
Published: November 2024

Abstract
The current inheritance of traditional handicrafts has ushered in unprecedented historical opportunities and challenges. This paper explains the process of designing handicraft products that are not heritage-based by describing traditional handicraft products. Using image processing technology, the collected images are pre-processed, and after extracting the image features based on a clustering algorithm, the features are reorganized, deduced, and fused using shape grammar to achieve the purpose of NRH’s innovative design. The Kano model is used to analyze the demand for non-heritage innovation design based on shape grammar. The top 5 user demand items of importance for NRH product innovation design are durability (0.7982) > utility (0.7906) > ethnic difference (0.7887) > regional culture (0.7223) > personalized design (0.7507). The combination of the Kano model and information technology enables precise positioning of the entire process of NRH innovation design.
Analysis of Students’ Critical Thinking Skills in Nervous System Learning Based on the Level of School Favoritism in Sleman Regency
Authors: Wulandari* Novia Dian Kartika , Kuswandi Paramita Cahyaningrum , Khan Farwa Hafeez 
Published: November 2024

Critical thinking skills (CTS) are importante cognitive ability to be improved by students in solving problems in the future. This ability needs to be trained in learning at school to equip students in the 21st century. Problems with students' CTS can lead to a decrease in the quality of education and the quality of students. The purpose of this study was to analyze the profile of CTS of high school students at Sleman Regency in biology learning, especially on the topic of the nervous system. This type of research is descriptive research. The research was conducted in six high schools throughout Sleman Regency. The population in this study is grade XI students in six high schools consisting of two most favorite category schools, two favorite category schools, and two less favorite category schools in Sleman Regency. Sampling using random purposive sampling method from six high schools in Sleman Regency totaling 216 students. The data collection technique using the question test method is using test instrument sheet. The data analysis technique used quantitative descriptive. The results showed that the CTS of high school students at Sleman Regency in biology learning reached an average of 46.6% in the medium category. Schools with most favorite categories have the highest CTS for all aspects tested compared to favorite and less favorite category schools. Meanwhile, the lowest CTS is the less favorite category of schools. This shows that schools with most favorite categories have better CTS for all aspects
Development of Canva-based Website Media on Class X for Virus Topic in Biology Learning
Authors: Nurhidayah Nurhidayah , Syamswisna Syamswisna , Titin* Titin , Haruno Mai 
Published: November 2024

The current technological advancements have a crucial role in education, bringing about innovations in the learning process. One form of innovation is using website media as a learning tool. This research aims to assess the feasibility and students' responses towards a Canva-based website learning media on viruses for high school X grade. The study follows the research and development approach using the ADDIE method. In this research using random sampling technique. The sample research used 10 students of XI MIPA 2 at SMAN 2 Teluk Keramat. Instruments utilized include validation sheets and student response questionnaires. The data analysis calculates the validation using Aiken's V formula and average score of student response and classifies into available categories. Validation was carried out by 2 biology lecturers at Untan and 3 biology teachers. The validation analysis using Aiken's V yielded a score of 0.89 for the Canva-based website media on virus topic, categorized as valid. The questionnaire analysis revealed an average response rate of 83.82%, indicating a very strong category of acceptance. Based on these results, it can be concluded that the Canva-based website media is suitable for use as a learning media on class X for virus topic
Pengaruh Pengetahuan, Sikap Kewirausahaan dan Prakerin terhadap Kesiapan Berwirausaha
Authors: Antonius Antonius , Handoyo Sarwo Edy 
Published: November 2024

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengetahuan kewirausahaan, sikap kewirausahaan dan prakerin terhadap kesiapan berwirausaha. Teknik pemilihan sampel dalam penelitian ini menggunakan teknik non probability sampling dengan metode purposive sampling. Sampel dalam penelitian ini merupakan mahasiswa yang pernah mengambil mata kuliah kewirausahaan, sudah pernah melakukan magang dan berkuliah di daerah Jakarta dengan total sebanyak 102 responden. Data dianalisis menggunakan metode SEM dengan aplikasi SmartPLS 3.0. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh yang positif dan signifikan antara pengetahuan kewirausahaan, sikap kewirausahaan terhadap kesiapan berwirausaha, prakerin berpengaruh positif dan tidak signifikan terhadap kesiapan berwirausaha.

This study aims to determine and analyze entrepreneurial knowledge, entrepreneurial attitudes and prakerin to entrepreneurial readiness. The sample selection technique in this study uses non probability sampling technique with purposive sampling method. The sample in this study were students who had taken entrepreneurship courses, had done internships and studied in the Jakarta area with a total of 102 respondents. The data were analyzed using the SEM method with the SmartPLS 3.0 application. The results of this study indicate that there is a positive and significant influence between entrepreneurial knowledge, entrepreneurial attitudes towards entrepreneurial readiness, internship has a positive and insignificant effect on entrepreneurial readiness.
Pengaruh Customer Review dan Brand Trust terhadap Purchase Intention Nature Republic E-Commerce Sociolla
Authors: Chandra Marcella Nasya , Ekawati Sanny 
Published: November 2024

Penelitian ini bertujuan untuk menguji pengaruh ulasan pelanggan online dan kepercayaan merek terhadap minat pembelian produk Nature Republic di e-commerce Sociolla. Ukuran sampel berjumlah 178 konsumen produk Nature Republic di Jakarta. Metode pengambilan sampel yang digunakan adalah non-­probability sampling dengan teknik purposive sampling dan instrumen penelitian yang digunakan kuesioner yang kemudian diolah menggunakan SEM-PLS. Temuan penelitian ini menunjukkan bahwa ulasan pelanggan online tidak memiliki pengaruh yang signifikan terhadap minat pembelian, sedangkan kepercayaan merek berpengaruh positif signifikan terhadap minat pembelian.

This study aimed to examine the effect of online customer reviews and brand trust on the purchase intention of Nature Republic products in Sociolla e-commerce. The sample size was 178 consumers of Nature Republic products in Jakarta. The sampling method used is non-probability sampling with purposive sampling techniques and research instruments used questionnaires which are then processed using SEM-PLS. The findings of this study indicate that online customer reviews do not have a significant effect on purchase intention, whereas brand trust have a significant positive effect on purchase intention.
DESAIN MODUL HUNIAN KHUSUS SENIMAN
Authors: Yobe Norlando Thomson Carlheinzt , Winata Suwardana 
Published: November 2024

The Ismail Marzuki Park Art Center has become an area for artists to work and exhibit. In 2019-2024, the art center is undergoing revitalization, but artists and culturalists are protesting this change, one of which is the change of the artist's special wedding function to the hotel. This leads to a loss of identity in the area because the artists who were supposed to revive the area of the art center now disappear and set up their own posko with a badge. In fact, artists with a wide range of skills also need space to work. The purpose of writing this journal is to study, understand, and explore the humane modules that support the artist in creating, preserving, and displaying or showcasing the work of the artist. In addition, this space can also accommodate tools and materials other than the reactions of the artist with his art in the space, so that the discovery of sufficient space loads can be achieved. It is obtained and studied through spatial study methods, literature studies, or other mediators that can support it. Therefore, a number of space indicators are suitable for artists with direct analysis methods on self-made two- or three-dimensional space image modules. As a result, there are some recommended spaces to be used in the artist's special dwellings.
Keywords: Art; Artist; Creation; Space
Abstrak
Pusat seni Taman Ismail Marzuki telah menjadi area untuk berkarya dan menampilkan karya para seniman. Pada tahun 2019-2024 pusat seni ini mengalami revitalisasi, namun para seniman dan budayawan memprotes perubahan ini salah satunya adalah karena perubahan fungsi wisma khusus seniman menjadi hotel. Hal ini menimbulkan Hilangannya identitas pada kawasan karena seniman yang semestinya menghidupkan area pusat seni, kini menghilang dan mendirikan posko sendiri dengan tagar savetim. Sebenarnya seniman dengan berbagai macam keterampilan yang dimiliki juga membutuhkan ruang untuk berkarya. Tujuan penulisan jurnal ini adalah untuk mempelajari, memahami, dan mengeksplorasi modul hunian yang mendukung seniman untuk berkreasi, menyimpan, dan memajang atau menunjukkan karya yang telah dibuat oleh sang seniman. Selain itu, ruang ini juga dapat mengakomodasi alat-alat dan bahan-bahan selain itu aksi-reaksi seniman dengan seninya di dalam ruang tersebut, agar penemuan terhadap muatan ruang yang cukup dapat tercapai. Hal ini didapatkan dan dipelajari melalui metode studi ruang, kajian literatur, maupun mediator-mediator lain yang dapat mendukung. Oleh karena itu, dibuat beberapa Indikator ruang yang cocok untuk seniman dengan metode analisis langsung pada modul gambar ruang yang dibuat sendiri secara dua maupun tiga dimensi. Hasilnya ada beberapa ruang yang direkomendasikan untuk digunakan pada hunian khusus seniman.
PENERAPAN METODE DISPROGRAMMING DALAM PENINGKATAN IDENTITAS DAN PERKEMBANGAN HERITAGE TOURISM PADA GALANGAN VOC
Authors: Salsabila Aurellia Ghasani , Komala Olga Nauli 
Published: November 2024

Kawasan heritage merupakan sebuah kawasan dengan peninggalan sejarah yang perlu dilestarikan keberadaannya. Sunda Kelapa Kota Tua dikenal sebagai kawasan sejarah yang menjadikanya salah satu destinasi wisata bagi turis lokal hingga mancanegara. Sebagai kota metropolitan, Jakarta tak luput dengan kehidupan modernitas. Akibatnya, pada kawasan sejarah ini didapati sebuah area yang mengalami degradasi akibat paparan fenomena modernitas. Area tersebut adalah komplek bangunan Gedung Galangan VOC. Galangan VOC merupakan salah satu bangunan tua peninggalan era kolonial Belanda dengan begitu banyak cerita sejarah didalamnya. Kini bangunan Gedung GalanganVOC termasuk dalam golongan bangunan bersejarah dikawasan cagar budaya Kota Tua. Degradasi yang terjadi pada area Gedung Galangan VOC ini berupa degradasi fisik dan juga fungsi sehingga membuatnya kurang merespon dan tidak menyesuaikan secara konteks. Menanggapi permasalahan degradasi tersebut, dilakukan upaya perumusan solusi arsitektural dalam mengatasi isu-isu yang menghambat perkembangan Galangan VOC sebagai wisata sejarah dalam bentuk cagar budaya, dengan pendekatan metode Disprogramming guna menemukan peluang yang ada, diharapan kan mampu membantu menghidupkan kembali, menjaga keberadaan serta membantu melestarikan bangunan Gedung Galangan VOC ini. Temuan penelitian ini diharapkan mampu menjadi solusi yang tepat untuk menjaga keaslian Gedung Galangan VOC ini dan menjadi daya tarik yang lebih bagi wisatawan.