bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidermal growth factor receptor (EGFR) T790M mutation identified in plasma indicates failure sites and predicts clinical prognosis in non‐small cell lung cancer progression during first‐generation tyrosine kinase inhibitor therapy: a prospective observational study
Authors: Zhang Shirong , Zhu Lucheng , Xia Bing , Chen Enguo , Zhao Qiong , Zhang Xiaochen , Chen Xueqin , Chen Xufeng , Ma Shenglin 
Published: May 2018

AbstractIntroductionPlasma circulating tumor DNA (ctDNA) is an ideal approach to detecting the epidermal growth factor receptor (EGFR) T790M mutation, which is a major mechanism of resistance to first‐generation EGFR‐tyrosine kinase inhibitor (TKI) therapy. The present study aimed to explore the association of ctDNA‐identified T790M mutation with disease failure sites and clinical prognosis in non‐small cell lung cancer (NSCLC) patients.MethodsPatients who progressed on first‐generation TKIs were categorized into failure site groups of chest limited (CF), brain limited (BF) and other (OF). Amplification refractory mutation system (ARMS) and droplet digital PCR (ddPCR) were used to identify the T790M mutation in ctDNA. Prognosis was analyzed with Kaplan–Meier methods.ResultsOverall concordance between the two methods was 78.3%. According to both ARMS and ddPCR, patients in the OF group had a significantly higher rate of T790M mutation than did patients in the BF and CF groups (P < 0.001), and a significantly higher T790M mutation rate was also observed in OF‐group patients than in those in the CF and BF groups (P < 0.001). AZD9291 was found to be an excellent treatment option and yielded the longest survival for T790M+ patients in all groups who had progressed on EGFR‐TKIs; for other treatments, the prognosis of T790M− patient subgroups varied.ConclusionsThe present study demonstrates that T790M mutation in ctDNA is associated with failure sites for NSCLC patients after EGFR‐TKI therapy and indicates that both failure site and T790M mutational status greatly influence treatment selection and prognosis.
Comparison of Nine Tools for Screening Drug-Drug Interactions of Oral Oncolytics
Authors: Marcath Lauren A. , Xi Jingyue , Hoylman Emily K. , Kidwell Kelley M. , Kraft Shawna L. , Hertz Daniel L. 
Published: May 2018

Purpose: Patients with cancer are an especially vulnerable population to potential drug-drug interactions (DDIs). This makes it important to adequately screen them for DDIs. The objective of this study was to compare the abilities of nine DDI screening tools to detect clinically relevant interactions with oral oncolytics. Methods: Subscription-based tools (ie, PEPID, Micromedex, Lexicomp, Facts & Comparisons) and free tools (ie, Epocrates Free, Medscape, Drugs.com, RxList, WebMD) were compared for their abilities to detect clinically relevant DDIs for 145 drug pairs including an oral oncology agent. Clinical relevance was determined by a pharmacist using Stockley’s Drug Interactions. Descriptive statistics were calculated for each tool, including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), and then compared grouped by free or subscription-based tools for the secondary analysis and analyzed via generalized estimating equations. Results: For individual metrics, PPV had overall higher values (0.88 to 0.97) relative to the low values included for sensitivity (0.65 to 0.96), specificity (0.53 to 0.93) and NPV (0.38 to 0.83). The top-performing subscription and free tools, Lexicomp and Drugs.com, had no statistically significant differences in performance. Overall, subscription tools had a significantly higher sensitivity (0.85 ± 0.017 v 0.78 ± 0.017; P = .0082) and NPV (0.57 ± 0.039 v 0.48 ± 0.032; P = .031) than free tools. No differences were observed between the specificity and PPV. Conclusion: Due to the low performance of some tools for sensitivity, specificity, and NPV, individual performance should be examined and prioritized on the basis of the intended use when selecting a DDI tool. If a strong-performing subscription-based tool is unavailable, a strong-performing free option, like Drugs.com, is available.
Elevated Levels of Organochlorine Pesticides in South Asian Immigrants Are Associated With an Increased Risk of Diabetes
Authors: Daniels Sarah I , Chambers John C , Sanchez Sylvia S , La Merrill Michele A , Hubbard Alan E , Macherone Anthony , McMullin Matthew , Zhang Luoping , Elliott Paul , Smith Martyn T , Kooner Jaspal 
Published: May 2018

Abstract

Objective
Rates of diabetes mellitus are higher in South Asians than in other populations and persist after migration. One unexplored cause may be higher exposure to persistent organic pollutants associated with diabetes in other populations. We compared organochlorine (OC) pesticide concentrations in South Asian immigrants and European whites to determine whether the disease was positively associated with OC pesticides in South Asians.

Research Design and Methods
South Asians of Tamil or Telugu descent (n = 120) and European whites (n = 72) were recruited into the London Life Sciences Population Study cohort. Blood samples as well as biometric, clinical, and survey data were collected. Plasma levels of p,p′-dichlorodiphenyldichloroethylene (DDE), p,p′- dichlorodiphenyltrichloroethane, β-hexachlorohexane (HCH), and polychlorinated biphenyl-118 were analyzed by gas chromatography-mass spectrometry. South Asian cases and controls were categorized by binary exposure (above vs below the 50th percentile) to perform logistic regression.

Results
Tamils had approximately threefold to ninefold higher levels of OC pesticides, and Telugus had ninefold to 30-fold higher levels compared with European whites. The odds of exposure to p,p′-DDE above the 50th percentile was significantly greater in South Asian diabetes cases than in controls (OR: 7.00; 95% CI: 2.22, 22.06). The odds of exposure to β-HCH above the 50th percentile was significantly greater in the Tamil cases than in controls (OR: 9.35; 95% CI: 2.43, 35.97).

Conclusions
South Asian immigrants have a higher body burden of OC pesticides than European whites. Diabetes mellitus is associated with higher p,p′-DDE and β-HCH concentrations in this population. Additional longitudinal studies of South Asian populations should be performed.
Halving the Volume of AnaConDa: Evaluation of a New Small-Volume Anesthetic Reflector in a Test Lung Model
Authors: Bomberg Hagen , Meiser Franziska , Daume Philipp , Bellgardt Martin , Volk Thomas , Sessler Daniel I. , Groesdonk Heinrich V. , Meiser Andreas 
Published: May 2018

BACKGROUND:
Volatile anesthetics are increasingly used for sedation in intensive care units. The most common administration system is AnaConDa-100 mL (ACD-100; Sedana Medical, Uppsala, Sweden), which reflects volatile anesthetics in open ventilation circuits. AnaConDa-50 mL (ACD-50) is a new device with half the volumetric dead space. Carbon dioxide (CO2) can be retained with both devices. We therefore compared the CO2 elimination and isoflurane reflection efficiency of both devices.

METHODS:
A test lung constantly insufflated with CO2 was ventilated with a tidal volume of 500 mL at 10 breaths/min. End-tidal CO2 (Etco
2) partial pressure was measured using 3 different devices: a heat-and-moisture exchanger (HME, 35 mL), ACD-100, and ACD-50 under 4 different experimental conditions: ambient temperature pressure (ATP), body temperature pressure saturated (BTPS) conditions, BTPS with 0.4 Vol% isoflurane (ISO-0.4), and BTPS with 1.2 Vol% isoflurane. Fifty breaths were recorded at 3 time points (n = 150) for each device and each condition. To determine device dead space, we adjusted the tidal volume to maintain normocapnia (n = 3), for each device. Thereafter, we determined reflection efficiency by measuring isoflurane concentrations at infusion rates varying from 0.5 to 20 mL/h (n = 3), for each device.

RESULTS:
Etco
2 was consistently greater with ACD-100 than with ACD-50 and HME (ISO-0.4, mean ± standard deviations: ACD-100, 52.4 ± 0.8; ACD-50, 44.4 ± 0.8; HME, 40.1 ± 0.4 mm Hg; differences of means of Etco
2 [respective 95% confidence intervals]: ACD-100 − ACD-50, 8.0 [7.9–8.1] mm Hg, P < .001; ACD-100 − HME, 12.3 [12.2–12.4] mm Hg, P < .001; ACD-50 − HME, 4.3 [4.2–4.3] mm Hg, P < .001). It was greatest under ATP, less under BTPS, and least with ISO-0.4 and BTPS with 1.2 Vol% isoflurane. In addition to the 100 or 50 mL “volumetric dead space” of each AnaConDa, “reflective dead space” was 40 mL with ACD-100 and 25 mL with ACD-50 when using isoflurane. Isoflurane reflection was highest under ATP. Under BTPS with CO2 insufflation and isoflurane concentrations around 0.4 Vol%, reflection efficiency was 93% with ACD-100 and 80% with ACD-50.

CONCLUSIONS:
Isoflurane reflection remained sufficient with the ACD-50 at clinical anesthetic concentrations, while CO2 elimination was improved. The ACD-50 should be practical for tidal volumes as low as 200 mL, allowing lung-protective ventilation even in small patients.
Measurement of pathological personality traits according to the DSM-5: A Polish adaptation of the PID-5. Part II – empirical results
Authors: Rowiński Tomasz , Kowalska-Dąbrowska Monika , Strus Włodzimierz , Cieciuch Jan , Czuma Iwona , Żechowski Cezary , Markon Kristian , Krueger Robert 
Published: May 2018

Cel pracyArtykuł prezentuje wyniki badań nad polską adaptacją Inwentarza Osobowości PID-5 (Personality Inventory for DSM-5) – narzędzia stworzonego do pomiaru patologicznych cech w ramach nowego, dymensjonalnego modelu zawartego w hybrydowym systemie diagnozy zaburzeń osobowości według sekcji III DSM-5.MetodaPrzeprowadzono badania w próbie klinicznej (N = 129 osób w wieku M = 32,40; SD = 9,08, z których 84,5% miało rozpoznane zaburzenie osobowości), oraz w próbie nieklinicznej (N = 1043, wieku M = 34,98; SD = 15,71) z wykorzystaniem inwentarzy PID-5 oraz MMPI-2 (Minnesota Multiphasic Personality Inventory – 2).WynikiWyniki badania potwierdziły rzetelność polskiej adaptacji inwentarza PID-5 (wysokie współczynniki zgodności wewnętrznej skal i podskal inwentarza w próbie klinicznej i zadowalające w próbie nieklinicznej) oraz jego trafność. Wszystkie skale i niemal wszystkie podskale PID-5 okazały się różnicować próbę kliniczną i próbę niekliniczną; skale i podskale PID-5 ujawniły także spójny wzorzec związków ze wskaźnikami pięciu wymiarów psychopatologii osobowości PSY-5 (Personality Psychopathology Five) oraz ze skalami klinicznymi MMPI-2.WnioskiUzyskane dane wskazują, że PID-5 jest satysfakcjonującą operacjonalizacją modelu patologicznych cech osobowości, potwierdzając jednocześnie obiecującą wartość naukową samego modelu DSM-5.
The African Metropolis and the aesthetics of superfluity
Authors: Ritzer Ivo 
Published: May 2018

Abstract
Drawing on Achille Mbembe’s idea of superfluity as both quantity and a paradoxical hybrid of indispensability and expendability in a city’s life, this article maps out possible relations between aesthetics and politics, aiming to understand the often contradictory spectrum of cultural and artistic production in an urban context. Looking at recent negotiations of the African Metropolis in media culture, the article not only attempts to describe artistic practices as preoccupied with conspicuous spectacle but also to come to grips with a contemporary aesthetics that itself imagines the African Metropolis in a hysterical way, obsessed with thrills and a rush for the rush.
The landscapes and aesthetics of soap opera: Townships, television and tourism
Authors: Gibson Sarah 
Published: May 2018

Abstract
The aesthetics of soap opera have been neglected within Television Studies, despite renewed interest in the aesthetics of television. Soap opera has frequently been regarded as a textual object unworthy and incapable of sustaining aesthetic attention, and the limited work that has been done on the cinematography of soap opera focuses on its realism. This article returns to debates on the cinematography of soap opera by focusing on the televisual aesthetic of the South African soap opera, Uzalo (2015–present). The visual pleasures of the landscapes of KwaMashu and KwaZulu-Natal distinguish it from other soap operas and offer new ways of understanding the aesthetics of soap opera. These ‘landscapes of television’ offer new ways of interpreting the conventionally ‘realist’ genre of soap opera through notions of the ‘spectacular’. Uzalo’s cinematography is read as an example of soap opera’s ‘spectacular realism’ that promotes a televisual tourist glance.
When the Chevalier d’Éon met Alexander McQueen: History, gender and subjectivity in the costumes in Eonnagata
Authors: Bancroft Alison 
Published: May 2018

Abstract
This article is a psychoanalytically inflected reading of two of the costumes that Alexander McQueen designed in 2008 for the contemporary dance piece Eonnagata. These costumes were notable because they were McQueen’s only work for theatre. He accepted the invitation to contribute to the project because it offered a collaborative way of working and also because he had a profound interest in the subject matter – the Chevalier d’Éon, the famous eighteenth-century courtier, soldier and spy who lived both as a woman and as a man. McQueen himself showed a clear interest throughout his life both in the problematic nature of the human condition and in the interior life of the mind. Psychoanalysis is concerned with the interior life and its manifestation in the wider, social world, and its particular understanding of subjectivity marries closely with McQueen’s own understanding of the human subject as being fundamentally a matter of the mind. Thus, bringing psychoanalysis to bear on a discussion of McQueen’s work in Eonnagata will, I believe, produce particular insights that go beyond the discussions of gender that are the usual interpretive context for the story of the Chevalier d’Éon and that might not otherwise be apparent.
MASK: Dialogue between an inside and an outside perspective of costume
Authors: Østergaard Charlotte 
Published: May 2018

Abstract
This visual essay introduces an independent collaborative artistic research project between costume designers Charlotte Østergaard and Jeppe Worning utilizing mask as costume to examine one’s relationship to the MASK from two perspectives: inside and outside. The research process starts with artistic practice: beginning by interacting with the objects/materials of study, we engage in a critical dialogue with the experiences we invoke. How can we as costume designers have an awareness of the costume from within and at the same time keep a gaze from the outside? Starting from the inside, we must dare to act as performers wearing the object of study, feeling it from the inside. As a wearer, the feeling of the material on the body may be a personal experience; it is also critical to incorporate a second perspective – perceiving the MASK from the outside. This project provoked a critical dialogue between the sensorial feeling (inside) and the visual expression (outside) of the mask. The dialogue between these two perspectives challenges us to become ‘active observers’ to our artistic expression.
Character and costume in cinema: The Hollywood Costume exhibition
Authors: Nadoolman Landis Deborah 
Published: May 2018

Abstract
During a masterclass held in 2012, and in reference to her extensive publishing on film costume design, Deborah Nadoolman Landis invited the audience to also write on the subject, noting ‘I ask my colleagues if I am to be the only one to fill the shelf with books on costume design and film’. Landis was the curator of the V&A exhibition, Hollywood Costume, the most comprehensive exhibition of its kind in decades. The exhibition analysed the extensive and detailed process employed to create a character through costume. Landis’ paper, on 22 April 2012, launched a series of talks titled Marking the Paradigm Shift in Design for Performance Through Costume organized by Donatella Barbieri for the Research Hub in Design for Performance at London College of Fashion, University of the Arts London. The above quote and those that follow are edited with Landis from a transcript of the event.
“Caliphate” against the Crown: Martyrdom, Heresy, and the Rhetoric of Enemyship in the Kingdom of Jordan
Authors: Fowler Randall 
Published: May 2018

Abstract
The execution of captured Jordanian pilot Muath al-Kasasbeh in February 2015 by Daesh (or ISIS) forces generated large public outcry in Jordan and thereby presented the regime of King Abdullah II with a moment of danger. In response to this rhetorical situation, the Abdullah regime engaged in rhetorics of enemyship based on appeals to religious orthodoxy, authoritarian ideology, and apocalyptic language. By examining these texts, this essay seeks to draw from contemporary rhetorical scholarship on terrorism, enemyship, and mass violence to expand the heuristic scope of the rhetoric of enemyship to include political rhetoric situated outside democratic contexts.
The crystal structure of poly[bis(4-hydroxybenzoato-κO)-(μ2-4,4′-bipyridine-κ2
N:N′)copper(II)] hydrate, C24H20N2O7Cu
Authors: He Haiyan , Li Yuyang , Yang Qiucheng , Li Lei 
Published: May 2018

Abstract
C24H20N2O7Cu, monoclinic, C2/c, a = 19.6241(4) Å, b = 10.4639(2) Å, c = 10.7024(2) Å, β = 96.163(2)° V = 2184.99(8) Å3, Z = 4, R
gt(F) = 0.0312, wR
ref(F
2) = 0.0863, T = 293 K.
Crystal structure of 4-phenyl-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione, C17H14N6S
Authors: Aouad Mohamed Reda , Messali Mouslim , Rezki Nadjet , Shivalingegowda Naveen , Warad Ismail 
Published: May 2018

Abstract
C17H14N6S, orthorhombic, P212121 (no. 19), a = 7.3832(3) Å, b =14.4702(7) Å, c = 15.2806(7) Å, V = 1632.52(13) Å3, Z = 4 and with R
int = 0.0577, R
gt(F) = 0.0358, wR
ref(F
2) = 0.0944, T = 296(2) K.
Crystal structure of 1,1′-(pentane-1,5-diyl)bis(3-methyl-1H-imidazol-3-ium)bis(hexafluorophosphate), C13H22F12N4P2
Authors: Wan-Ming Xiong , Long Zhou , Shen-Ming Lv , Xu-Liang Nie , Jing Chen , Chang-Gan Huang 
Published: May 2018

Abstract
C13H22F12N4P2, monoclinic, P21/c, a = 12.9171(13) Å, b = 13.3953(13) Å, c = 12.5808(12) Å, β = 97.766(1)°, V = 2156.9(4) Å3, Z = 4,R
gt(F) = 0.0583, wR
ref(F
2) = 0.1557, T = 296(2) K.
Crystal structure of 1,1-di(4-cyanophenyl)-2,2-diphenylethene, C28H18N2
Authors: Bao-Xi Miao , Hao Sun , Zhong-Hai Ni 
Published: May 2018

Abstract
C28H18N2, orthorhombic, Pccn (no. 56), a = 9.8955(6) Å, b = 11.0163(6) Å, c = 19.9752(14) Å, V = 2177.5(2) Å3, Z = 4, R
gt(F) = 0.0402, wR
ref(F
2) = 0.1012, T = 123(2) K.
The crystal structure of chlorido(2-(1H-pyrazol-3-yl)phenolato-κ2
N,O)(2-(1H-pyrazol-3-yl)phenol-κN)copper(II), C18H15ClCuN4O2
Authors: Li Wu-Wu , Zheng Min-Yan , Zhang Zun-Ting 
Published: May 2018

Abstract
C18H15ClCuN4O2, triclinic, P1̄ (no. 2), a = 8.938(3) Å, b = 9.228(3) Å, c = 12.127(6) Å, α = 105.478(7)°, β = 110.358(8)°, γ = 99.727(6)°, V = 865.0(6) Å3, Z = 2, R
gt(F) = 0.0504, wR
ref(F
2) = 0.1447, T = 296(2) K.
Correlation of clinical grading, physical tests and nerve conduction study in carpal tunnel syndrome
Authors: Izadi Sadegh , Kardeh Bahareh , Hooshiar Seied Saeed Hosini , Neydavoodi Mojtaba , Borhani-Haghighi Afshin 
Published: May 2018

Abstract

Background and aims
Carpal tunnel syndrome (CTS) is a common debilitating condition. As the reliability of CTS-specific physical tests and its clinical grading remain a matter of debate, we determined the correlations between these assessments with nerve conduction study (NCS).

Methods
In this cross-sectional study, patients with uni or bilateral CTS, which was confirmed in electrodiagnosis, were enrolled. Clinical grading was based on the modified criteria of the Italian CTS Study Group. Numeric Pain Rating Scale (NPRS) and Boston Questionnaire (BQ) were used. Physical tests [Phalen’s, reverse Phalen’s, Tinel’s and manual carpal compression test (mCCT)] were performed by a single blinded neurologist. A p-value<0.05 was considered statistically significant.

Results
A total of 100 patients (age=47.48±11.44 years; 85% female) with 181 involved hands were studied. The majority of hands (59.7%) were classified as grade 2 of clinical grading. On NCS, hands with mild (64%), moderate (27%) and severe (9%) CTS were identified. Sensory (velocity, latency and amplitude) and motor parameters (latency and amplitude) were significantly correlated with clinical grades (p-value<0.001). The correlation of NPRS (p-value=0.009) and BQ (p-value<0.001) scores with NCS was significant. None of the physical tests were significantly correlated with NCS in terms of result or duration (p-value>0.05).

Conclusions
We found that physical tests are not a reliable screening method for evaluation of CTS severity. However, the BQ and clinical grading can be more valuable due to their significant correlation with NCS.

Implications
Physicians might benefit from employing clinical grading and BQ in practice for better assessment of CTS severity.
Tyrosinase inhibition potency of phthalimide derivatives: crystal structure, Hirshfeld surface analysis and molecular docking studies
Authors: Then Li Yee , Kwong Huey Chong , Quah Ching Kheng , Chidan Kumar C.S. , Chia Tze Shyang , Wong Qin Ai , Chandraju Siddegowda , Karthick Thangavel , Win Yip-Foo , Sulaiman Shaida Fariza , Hashim Nurul Shafiqah , Ooi Kheng Leong 
Published: May 2018

Abstract
A new series of seven 2-((pyridinylamino)methyl)isoindoline-1,3-dione derivatives were synthesized under mild condition and characterized by spectroscopy analysis. The crystal structures of these derivatives were further determined using single crystal X-ray diffraction technique. All derivatives adopt a V-shape conformation. The dihedral angle between phthalimide and pyridine rings increases as the torsion angle C1–N1–C9–N2 between phthalimide ring and methylene group increases. The torsion angles and molecular conformations are comparable to those related structures from the Cambridge Structural Database (CSD). Furthermore, the intermolecular interactions of all studied crystal structures were quantified and analyzed using Hirshfeld surface (HS) analysis. The quantitative data on the percentage contributions of overall interactions in all compounds are calculated by the two-dimensional (2D) fingerprint plots from the HS analysis. These compounds were evaluated for their antioxidant and antityrosinase properties. Noteworthy, 2-(((6-methoxypyridin-3-yl)amino)methyl)isoindoline-1,3-dione (compound g) exhibited higher tyrosinase inhibitory activity (EC50=753 μg/mL) than the positive control ‘arbutin’ (EC50=403 μg/mL). The inhibitory effect of compound g was further confirmed by computational molecular docking studies and the result revealed the 6-methoxypyridin-3-yl substituent has a better binding affinity toward tyrosinase.
Larval hemolymph of rhinoceros beetle, Allomyrina dichotoma, enhances insulin secretion through ATF3 gene expression in INS-1 pancreatic β-cells
Authors: Kim Seung-Whan , Suh Hyun-Woo , Yoo Bo-Kyung , Kwon Kisang , Yu Kweon , Choi Ji-Young , Kwon O-Yu 
Published: May 2018

Abstract
In this study, we show that INS-1 pancreatic β-cells treated for 2 h with hemolymph of larvae of rhinoceros beetle, Allomyrina dichotoma, secreted about twice as much insulin compared to control cells without such treatment. Activating transcription factor 3 (ATF3) was the highest upregulated gene in DNA chip analysis. The A. dichotoma hemolymph dose-dependently induced increased expression levels of genes encoding ATF3 and insulin. Conversely, treatment with ATF3 siRNA inhibited expression levels of both genes and curbed insulin secretion. These results suggest that the A. dichotoma hemolymph has potential for treating and preventing diabetes or diabetes-related complications.