bluuebunny/crossref_metadata_2025_split huggingface dataset:
To a Question of Predicting Model Stability on the Basis of Multiple Scale Wavelet Transformation
Authors: Sakrutina E. A. 
Published: July 2019

Purpose of research. The article is devoted to the development of production predicting models and their stability conditions.Methods: Predicting models are actively used in modern control systems, in information support intellectual systems of decision-making. They have a huge role in any activity connected with signals' processing including anomalies detection of various technological processes and assessment of risk potential of critical information infrastructure objects. They can also be used in monitoring systems of security threats. Special class among predicting models is represented by the models based on experiences of proceeding processes (for example, regularities taken from the data which are saved up as a result of an object work).Results. Virtual "instant" model of an object belonging to this class is described in the article. It is presented taking into account multiple and large-scale decomposition of entrance influences vectors and the forecast of an object output. The described model gives the forecast without possible future conditions of an expected background. The approach based on the wavelet-analysis which is characterized by a unique opportunity of detailed frequency analysis in time is developed for stability study of virtual "instant" model. Stability conditions of the predicting model are received on the basis of this approach. This model has allocation conditions for approximating and detailing components for four types of ratios between memory depth on input and output.Conclusion: Predicting model of oil processing in which memory depth on an input is more than memory depth on output is described in the article. It is shown that the accuracy of virtual "instant" model forecast is higher than linear predicting model has at rare data of laboratory analysis. One of stability conditions depending on decomposition depth is shown for the constructed model. On the basis of received results analysis it is possible to draw a conclusion on applicability of received stability conditions for risk potential assessment of process development forecast implementation in monitoring systems of security threats.
Information Technologies for Assessing the Risk to Public Health from Emissions of Municipal Solid Waste Landfills
Authors: Kiril’chuk I. O. , Kondrat’yeva O. E. , Laktionov O. A. , Yushin V. V. 
Published: July 2019

Purpose of reseach. One of the most pressing environmental problems is the formation of production and consumption waste; moreover, the bulk of the waste is not involved in the circular economy but is disposed at landfills and waste dumps that pose a serious ecological hazard to the environment and public health. The authors of the article substantiate the need to apply modern information technologies for a qualitative and quantitative analysis of the composition of emissions, a comprehensive assessment of the environmental state near sources of pollution, a study of cause-effect relationships in the ‘environment – public health’ system, and health risk assessment for the subsequent justification of the priority management decisions to ensure the environmental health and public safety.Methods. The main method used to assess the negative impact of municipal solid waste landfills on the health of the population living in the areas of their effect is the concept of risk assessment and analysis.Results. Particular attention was paid to the analysis of information technologies used in assessing the risk to public health from emissions of landfills of municipal solid waste; examples of using software products at various stages of assessing the risk to public health from emissions from Kursk landfill were considered. To take into account the specific uncertainties that are due to the peculiarities of the functioning of municipal solid waste landfills as risk sources, the authors developed an electronic database of the municipal solid waste morphological composition and landfill facilities.Conclusion. The developed database will allow us to level the uncertainties that arise in assessing the risk to public health from emissions of municipal solid waste landfills to the extent possible, and, so, increase the objectivity of the obtained risk assessment results.
Influence of Operating Modes of High-Temperature Thermomechanical Processing on Mechanical Properties of Reinforcing Bars
Authors: Sergeev N. N. , Sergeev A. N. , Kutepov S. N. , Gvozdev A. E. , Ageev E. V. 
Published: July 2019

The strenghening thermomechanical treatment represens the combined processing treatment – a combination of plastic deformation and hardening in one technological process. Year after year, it is more widely applied in industry.Purpose of research. The study of strenghening thermomechanical treatment operating modes influence on the formation of mechanical properties of steel, which is a very important scientific problem associated with obtaining materials with a given set of mechanical features.Methods. High-temperature thermomechanical treatment was conducted under the conditions in which the processes of recrystallization of deformed austenite were partially or completely supressed, and the process of polygonization got the most development, with the goal of forming a developed substructure of austenite inherited by martensite during subsequent quenching.The paper investigated the change in the properties of high-strength reinforcement under heating (tempering) with different intensity. High-temperature thermomechanical treatment was carried out by including a hardening device in the technological line of the mill No. 280 LLC “Tulachermet-steel”. The studies were carried out on two modes of mill No. 280 operation. Low-carbon reinforcing steels St3 and ST5 were accepted as the studied steels.Results. It has been experimentally established that the maximum cooling capacity of the existing hardening device is manifested when three working sections with a water pressure of about 13 in each section are turned on. In this case, high-temperature thermomechanical treatment should be carried out at the maximum cooling rate in the strengthning device in accordance with the specified strength class, i.e., include the least number of working sections. Intensive cooling mode contributes to the formation of a homogeneous structure in the reinforcement with a high mechanical complex. It was found that during high-temperature thermomechanical treatment it is advisable to withstand the deformation temperature in the range of 1000...1050 ℃ to guarantee the production of reinforcement of a given class. It has been shown that the inclusion of a strengthening device in the mill line directly behind the flying shears, and not behind the finishing stand of the mill leads not only to the trouble-free operation of shears, but also to an increase in the post-deformation aging between the end of deformation and the beginning of bar hardening to a value close to the optimal, responsible for the formation of a polygonal substructure in austenite, the inheritance of which by martensite provides high mechanical properties of steel after high-temperature thermomechanical treatment.Conclusion. These results can be applied to create resource-saving material treatment processes.
DESIGN AND OPTIMIZATION OF PEDIATRIC CEFUROXIME AXETIL DISPERSIBLE TABLET CONTAINING ION-EXCHANGE RESIN
Authors: OZA NISHANT , SAGAR SWATI 
Published: July 2019

Objective: The aim of present work was to develop of pediatric cefuroxime axetil 125 mg dispersible tablets by using ion exchange resin as a taste masking agent and quality target product profile was defined based on the properties of the cefuroxime axetil.
Methods: Initially, cefuroxime axetil and various resin complexes (DRC) were prepared with different conditions and evaluated for taste masking and drug loading. Optimized DRC was used to formulate the dispersible tablet. A 32 full factorial design was employed to study the effect of mannitol (X1) and microcrystalline cellulose PH-101 (X2) on drug release at 10 min and time taken to 80% drug release. In the present study, the following constraints were arbitrarily used for the selection of an optimized batch: Q10>65% and T80%<30 min. Multiple linear regression analysis, ANOVA and graphical representation of the influence factor by 3D plots were performed by using Sigmaplot 11.0. Checkpoint batch was prepared to validate the evolved model.
Results: Among the various drug resins complex DRC-9 was found with less bitter taste which was containing kyron T-114 and among the all factorial batch F7 showed highest drug release at 10 min (Q10) and lowest time taken to 80% drug release (T80) hence batch F7 was selected as an optimized batch and it’s found to be stable in the stability evaluation.
Conclusion: The results of full factorial design indicate mannitol and MCC PH-101 have a significant effect on drug release.
FORMULATION DEVELOPMENT OF IMMEDIATE RELEASE PELLETS OF TADALAFIL: SOLIDIFICATION APPROACH FOR NANOSUSPENSION
Authors: UBGADE SHOBHA , KILOR VAISHALI , BAHEKAR VIDYA , ITTADWAR ABHAY 
Published: July 2019

Objective: Nanosuspension is known to enhance the saturation solubility and dissolution velocity of poorly soluble drugs owing to the increased surface area of nanosized particles. Stability of these solubility enhancing systems can be improved by converting them into solidified forms. To simultaneously achieve enhanced dissolution and improved stability, an attempt has been made to increase the dissolution rate of poorly soluble drug tadalafil by formulating immediate release pellets of its nanosuspension.
Methods: Tadalafil nanosuspensions were prepared using high shear homogenization technique and hydroxypropyl methylcellulose (HPMC) E 15, sodium dodecyl sulphate (SDS) as stabilizers. Prepared nanosuspensions were subjected to the characterization of particle size distribution, zeta potential, drug loading and saturation solubility. Optimized nanosuspension was solidified by preparing immediate release pellets: for improved stability, where tadalafil nanosuspension was used as a binder. Pellets were prepared by extrusion-spheronization technique using κ-carrageenan as a pelletizing aid.
Results: Prepared immediate release pellets disintegrated within 03 min. In vitro dissolution studies showed 85% drug release within 45 min in pH 1.2 buffer from immediate release pellets containing tadalafil nanosuspension.
Conclusion: It can be concluded that formulation of nanosuspension of poorly soluble drug and its use as a binder for the preparation of immediate release pellets markedly improved the dissolution rate.
APPLICATION OF 1H-NMR SPECTA AND MULTIVARIATE ANALYSIS FOR THE AUTHENTICATION OF CURCUMA XANTHORRHIZA FROM ZINGIBER CASSUMUNAR
Authors: WIJAYANTI THERESIA , RIYANTO SUGENG , LUKITANINGSIH ENDANG , ROHMAN ABDUL 
Published: July 2019

Objective: This study was aimed to apply metabolite fingerprinting for the authentication of Curcuma xanthorrhiza adulterated with Zingiber cassumunar using 1H-NMR spectroscopy and multivariate analysis (chemometrics) methods, namely principal component analysis (PCA) and partial least square–discriminant analysis (PLS-DA).
Methods: The pure dried powder samples of C. xanthorrhiza from different regions, Z. cassumunar, and its binary mixtures of C. xanthorrhiza with various concentrations of Z. cassumunar as adulterants were prepared for 1H-NMR measurements. The binary mixtures were prepared by mixing C. xanthorrhiza with various concentrations (10%, 25%, 40%, 50%, and 75%) of Z. cassumunar. 1H-NMR spectra were subjected to multivariate analysis for classification using PCA and PLS-DA.
Results: A diverse group of metabolites could be detected by 1H-NMR spectroscopy. PCA using the chemical shift in 1H-NMR spectra of the plant extracts as variables clearly discriminated pure C. xanthorrhiza extracts from different origins and C. xanthorrhiza extract adulterated with Z. cassumunar. PLS-DA employed to enhance the separation obtained from the PCA model resulted in well separation and good classification of pure C. xanthorrhiza from the adulterated ones.
Conclusion: The developed method could be a useful and powerfull tools to assess adulteration practice and to evaluate the authentication of C. xanthorrhiza extracts.
The THE INFLUENCE OF CHLORPROMAZINE HYDROCHLORIDE ON THE SIZE OF SMALL UNILAMELLAR DIMYROSTYLPHOSPHATIDYLCHOLINE LIPOSOMES AS REVEALED BY LIGHT SCATTERING PHOTOMETRY
Authors: Ahmed Farah hamad 
Published: July 2019

Objectives: This study aims to investigate the possible influence of the model, cationic, surface-active solute chlorpromazine hydrochloride (CPZ-HCl) on the size of small unilamellar dimyristoyl phosphatidylcholine (DMPC) liposomes as a function of temperature and CPZ-HCl concentration, below and above the critical micelle concentration (CMC).
Methods: Small unilamellar DMPC liposomes were prepared by dissolving DMPC in chloroform and the solvent was rota-evaporated in a water bath adjusted at 40 °C. The lipid film was then dispersed in 0.1 M KCl solution adjusted at pH 6.2 to form large multilamellar liposomes which are then sonicated and fractionated via Sepharose 2B-Cl gel. The elution profile was followed spectrophotometrically at λ 260 nm. Combined fractions from the trailing edge of the included peak which is due to small unilamellar liposomes, were used as a source throughout this study. The SOFICA light scattering photometer (Model 42000) was used to determine the weight average liposomes weight (Lw) of small unilamellar DMPC liposomes. The Lw was determined in the absence and presence of CPZ-HCl both above and below the CMC over the temperature range of 25 °C to 40 °C.
Results: The Lw was observed to increase linearly in the absence and presence of CPZ-HCl.
The Lw was observed to increase linearly in the absence of CPZ-HCl, from 1.88×106+0.02 g/mol at 25 °C to 3.25×106+0.03 g/mol at 40 °C. Similarly, the Lw was observed to increase linearly in the present of CPZ-HCl, for example at 18 mmol drug concentration, the Lw increases from 11×106+0.04 g/mol at 25 °C to 13.75×106+0.03 g/mol at 40 °C. When the data are presented as a function of CPZ-HCl concentration, a gradual increase in Lw was observed below the CMC. Little increase in Lw however, was observed at post-micellar concentrations of 14 mmol and 18 mmol.
EFFICIENT VALIDATED METHOD OF HPLC TO DETERMINE ENALAPRIL IN COMBINATED DOSAGE FORM CONTAINING ENALAPRIL AND BISOPROLOL AND IN VITRO DISSOLUTION STUDIES
Authors: Logoyda Liliya 
Published: July 2019

Objective: A rapid and reproducible HPLC method has been developed for the determination of enalapril in experimental combined dosage forms containing bisoprolol and enalapril and for drug dissolution studies.
Methods: The separation was done using a column Hi Qsil C18 (4.6х250 mm, 5 μm particle size) and a mobile phase of methanol: phosphate buffer solution (65:35, v/v), flow-rate of 1.0 ml/min. The injection volume was 300 μL and the ultraviolet detector was set at 225 nm.
Results: The method was validated as per ICH guidelines. Under these conditions, enalapril was eluted at 5.33 min. Total run time was shorter than 6 min. A linear relationship between the concentration and the area of ​​chromatographic peaks of enalapril in the range of 1.250 mg/ml–10.000 mg/ml (7.500 mg/ml at pH 1.2) was established. Requirements for linear dependency parameters are performed in this case throughout the range of application of the technique. Linearity studies were conducted in a wide range of concentrations (25-200% at pH 4.5 and 6.8, 25-150% at pH 1.2). In the medium with pH 1.2 release of enalapril from tablets in 5 min is 83.38 %, after 15 min-94.11%, after 30 min-97.17 %; in medium with pH 4.5 the release of enalapril from tablets in 5 min makes 47.13 %, after 15 min-88.34 %, after 30 min-95.86 %; in a medium with pH 6.8, the release of enalapril from tablets in 5 min is 71.04 %, and after 15 min-88.88 %, after 30 min-92.11 %.
Conclusion: A simple and sensitive HPLC method was developed for the estimation of enalapril in tablets containing enalapril and bisoprolol. The proposed method was applied successfully for quality control assay of enalapril in experimental tablets and in vitro dissolution studies.
WATER-SOLUBLE POLYMERIC IONIC 5-FLUOROURACIL COMPLEX BASED ON METHACRYLIC ACID COPOLYMERS
Authors: Zhukova Olga , RYABOV SERGEY A. , ZAITSEV SERGEY D. , KUZNETSOVA OLGA V. , GAVRILOVA DARIA M. , ARCHIPOVA EUGENIA V. , GOLOVACHEVA ANNA A. , VOLKOVA YULIA S. 
Published: July 2019

Objective: The objective of this work was to obtain a water-soluble 5-fluorouracil (5-FU) polymeric complex on the basis of a methacrylic acid (MAA) copolymer to be used as an injectable chemotherapeutic agent.
Methods: A polymeric carrier was synthesized using tert-butyl methacrylate (TBMA) as a monomer, thioglycolic acid, and azobisisobutyronitrile as a radical polymerization initiator. The polymer was converted by acid hydrolysis into a water-soluble copolymer of TBMA and MAA of 20: 80 mass%, respectively. The copolymer of TBMA and MAA was modified with 5-FU. Their formation was proved using IR and UV spectroscopy. The particle size of the 5-FU polymeric complex was estimated by turbidimetry, which is based on measuring the intensity of light transmitted through a disperse system. The release of 5-FU from the obtained ionic complexes by dialysis in vitro was evaluated.
Results: Polymeric carriers were obtained with different amounts of 5-FU (5, 15, 25, 50 mol%). A high peak at λ = 266 nm was observed in the UV spectrum of the polymeric carrier (characteristic of 5-FU). The particle size was estimated at 13 nm for the complex with 5 mol% 5-FU and 26.8 n for the complex with 50 mol% 5-FU. The 5-FU release was estimated in two parallel experiments at 37 °C. One utilized a phosphate-citrate buffer with pH 5.0 to model the intracellular space and the other, a phosphate buffer with pH 7.4 to model the intravascular space. Two systems, with 5 and 15 mol% 5-FU, were chosen for testing. In both phosphate buffer and phosphate-citrate buffer, 5-FU was released from the polymeric complex with 5 mol% 5-FU approximately 1.3 times faster than from the complex containing 5 mol% 5-fluorouracil. The kinetics of 5-FU release from the polymeric complex (5 mol% 5-fluorouracil) showed that the 5-FU release was 77.9% in phosphate-citrate buffer and 59.6% in phosphate buffer over 52 h of dialysis. When the 5-FU release kinetics was studied with the polymeric complex containing 15 mol% 5-FU, the 5-FU release was 100.0% in phosphate-citrate buffer and 75.1% in phosphate buffer over 57 h of dialysis.
Conclusion: Water-soluble nanoscale complexes of 5-FU with TBMA–MAA copolymers extend application of 5-FU, while its general toxicity might be lower. The complexes are sufficiently stable at pH 7.4 and readily release 5-FU at pH 5.0.
IN VITRO EQUIVALENCE STUDY OF DIFFERENT DOSES OF CARBAMAZEPINE REFERENCE TABLETS USING USP APPARATUSES 2 AND 4
Authors: MEDINA-LOPEZ JOSE RAUL , Cedillo-Díaz Luis Antonio , Hurtado Marcela 
Published: July 2019

Objective: To perform an in vitro equivalence study of two doses of carbamazepine reference tablets sold in the local market under hydrodynamic conditions of USP Apparatus 4, a dissolution apparatus that better simulates the human gastrointestinal tract. Results were compared with dissolution official conditions using USP Apparatus 2.
Methods: Dissolution profiles of both formulations were carried out with an automated USP Apparatus 2 at 75 rpm and 900 ml of dissolution medium. USP Apparatus 4 with laminar flow at 16 ml/min and 22.6 mm cells were used. 1% lauryl sulfate aqueous solution at 37.0±0.5 °C was used as dissolution medium. Spectrophotometric determination of drug at 285 nm was carried out during 60 min. Dissolution profiles were compared with model-independent and-dependent approaches.
Results: When comparing dissolution profiles of low vs. high dose similar profiles were found (f2>50) in each dissolution apparatus, however, when the same dose was compared, USP 2 vs. USP 4, opposite results were obtained. Comparison of mean dissolution time and dissolution efficiency data corroborates these results. Weibull function was the best mathematical model that described the in vitro dissolution performance of carbamazepine. No significant differences were found in Td values (low vs. high dose) but opposite results were also found with USP 2 vs. USP 4.
Conclusion: Equivalent dissolution performance of two doses of carbamazepine reference tablets were found in each USP dissolution apparatus. The main problem identified in this comparative study is the low dissolution rate and extent found with USP Apparatus 4. More research on this field is necessary for all available doses of reference drug products since the quality of generic formulations depends on the quality of references.
INVESTIGATION OF QUALITY TARGET PROCESS PARAMETERS (QTPP) AND CRITICAL MATERIAL ATTRIBUTES (CMA) OF NANOCELLULOSE AS A POTENTIAL EXCIPIENT
Authors: VORA ROSHNI , Shah Yamini 
Published: July 2019

Objective: The current work highlights the use of the Quality by Design (QbD) for optimization of Nanocellulose (NC) production from corn husk by two techniques, namely, Acid hydrolysis (AH) and High pressure homogenization (HPH).
Methods: Characterization of NC involved Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM). For the risk assessment, QbD Software was used. According to this results 32 factorial design was applied in which two independent variables (acid concentration and time for AH whereas pressure and no of passes for HPH) and two dependent variables (particle size and yield) were selected.
Results: FTIR showed similarity in the peaks which indicates there is no change in parent molecular structure of cellulose. TGA confirmed that the NC extracted by both the methods showed improved thermal property at onset temperature of 290 °C as compared to Avicel PH101, 270 °C. XRD results showed that the crystallinity index of the extracted nano cellulose from both the method was 83.15% which indicates transition and reorientation of corn husk into compact crystalline cellulosic structure after removal of non-cellulosic materials. TEM images indicated that the fibers were well dispersed and the treatment had reduced the size of fibers with average dimensions of 100 to 1000 nm in length. Product assay revealed that as the acid concentration and time is increased, narrow particle size is observed whereas lower number of passes and pressure resulted in a broader particle size. Studies on the variables and the experiment of NC preparation contributed a maximum yield of 77% in case of AH and 83 % in case of HPH.
Conclusion: Evident from the results, NC prepared by QbD approach had better flow property and compatibility. Hence it is suitable for usage as an excipient in product design for variety of tailor made customized oral dosage forms in pharmaceutical industry.