bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrategias de educación ambiental para promover la conservación del pato de torrente Merganeta armatta colombiana en dos instituciones educativas rurales del municipio de Salento, Quindío, Colombia
Authors: López-Londoño Juan Ernesto , Botero-Botero Álvaro 
Published: August 2019

El pato de torrente (Merganetta armata) se encuentra distribuido en la región Andina, en todo el continente suramericano. Esta especie presenta requerimiento específico de hábitat, como aguas libres de contaminación, vegetación ribereña abundante y baja presencia de humanos, lo que lo hace altamente vulnerables a los impactos antrópicos. Esto hace que las comunidades ribereñas cumplan un papel importante en la conservación de la especie y de los ecosistemas ribereños. Por ello, se diseñó e implementó una estrategia de educación ambiental para promover la conservación del pato de torrente M. armata colombiana en dos sedes rurales de la Institución Educativa Boquía, en el municipio de Salento (Quindío). Se trabajó con niños y niñas hijos de campesinos de las veredas Cócora y Palo Grande, donde se realizó un diagnóstico previo sobre los conocimientos básicos de los niños acerca de la especie, encontrándose que en general los niños desconocían el pato de torrente y solo estaban familiarizados con el estereotipo de los patos asociados a lagos. A partir de dicho diagnostico se diseñó una cartilla base de trabajo sobre diversos aspectos de la ecología, biología y conservación del pato de torrente, la cual acompañó la realización de cuatro jornadas de trabajo en cada centro educativo. Asociado a esto, se implementaron como refuerzos educativos carteleras, infografías y pato desafíos (juegos). Al evaluar la estrategia, se concluyó que los niños reconocieron la especie, su ecología y sus amenazas. Solo se presentó dificultad en la compresión de la dieta de la especie.
Polyoxometalates in Biomedicine: Update and Overview
Authors: Čolović Mirjana B. , Lacković Milan , Lalatović Jovana , Mougharbel Ali S. , Kortz Ulrich , Krstić Danijela Z. 
Published: August 2019

Background:
Polyoxometalates (POMs) are negatively charged metal-oxo clusters of
early transition metal ions in high oxidation states (e.g., WVI, MoVI, VV). POMs are of interest in
the fields of catalysis, electronics, magnetic materials and nanotechnology. Moreover, POMs were
shown to exhibit biological activities in vitro and in vivo, such as antitumor, antimicrobial, and antidiabetic.

Methods:
The literature search for this peer-reviewed article was performed using PubMed and
Scopus databases with the help of appropriate keywords.

Results:
This review gives a comprehensive overview of recent studies regarding biological activities
of polyoxometalates, and their biomedical applications as promising anti-viral, anti-bacterial,
anti-tumor, and anti-diabetic agents. Additionally, their putative mechanisms of action and molecular
targets are particularly considered.

Conclusion:
Although a wide range of biological activities of Polyoxometalates (POMs) has been
reported, they are to the best of our knowledge not close to a clinical trial or a final application in
the treatment of diabetes or infectious and malignant diseases. Accordingly, further studies should
be directed towards determining the mechanism of POM biological actions, which would enable
fine-tuning at the molecular level, and consequently efficient action towards biological targets and
as low toxicity as possible. Furthermore, biomedical studies should be performed on solutionstable
POMs employing physiological conditions and concentrations.
Active Amyloid-β Vaccination Results in Epigenetic Changes in the Hippocampus of an Alzheimer’s Disease-Like Mouse Model
Authors: Lardenoije Roy , van den Hove Daniël L.A. , Jung Sophie E. , Havermans Monique , Blackburn Peter , Liu Bin , Rutten Bart P.F. , Lemere Cynthia A. 
Published: August 2019

Background:
While evidence accumulates for a role of epigenetic modifications in the
pathophysiological cascade of Alzheimer’s disease (AD), amyloid-β (Aβ)-targeted active immunotherapy
approaches are under investigation to prevent or slow the progression of AD. The impact of Aβ active
vaccines on epigenetic markers has not been studied thus far.

Objective:
The current study aims to establish the relationship between active immunotherapy with a
MER5101-based vaccine (consisting of Aβ1-15 copies conjugated with a 7 aa spacer to the diphtheria
toxoid carrier protein, formulated in a Th2-biased adjuvant) and epigenetic DNA modifications in the
hippocampus of APPswe/PS1dE9 mice.

Methods:
As we previously reported, immunotherapy started when the mice were 10 months of age and
behavioral testing occurred at 14 months of age, after which the mice were sacrificed for further analysis
of their brains. In this add-on study, global levels of DNA methylation and hydroxymethylation, and
DNA methyltransferase 3A (DNMT3A) were determined using quantitative immunohistochemistry, and
compared to our previously analyzed immunization-induced changes in AD-related neuropathology and
cognition.

Results:
Active immunization did not affect global DNA methylation levels but instead, resulted in decreased
DNA hydroxymethylation and DNMT3A levels. Independent of immunization, inverse correlations
with behavioral performance were observed for levels of DNA methylation and hydroxymethylation,
as well as DNMT3A, while Aβ pathology and synaptic markers did not correlate with DNA methylation
levels but did positively correlate with DNA hydroxymethylation and levels of DNMT3A.

Conclusion:
Our results indicate that active Aβ vaccination has significant effects on the epigenome in
the hippocampus of APPswe/PS1dE9 mice, and suggest that DNA methylation and hydroxymethylation
may be involved in cognitive functioning.
Simultaneous Determination of Eight Potential Q-Markers in Zishen Tongguan Capsules Based on UHPLC-MS/MS
Authors: Liu Shun , Wang Xun , Zou Kaiping , Liu Wei , Li Cunyu , Zheng Yunfeng , Zhou Qinmei , Peng Guoping 
Published: August 2019

Background:
Zishen Tongguan (ZSTG) capsules were prepared at the Affiliated Hospital of Nanjing
University of Chinese Medicine and have been proven to be clinically effective for treating pyelonephritis and benign
prostatic hyperplasia. However, the quality standards are not ideal; a comprehensive study of the “quality markers”
(Q-markers), the chemicals inherent in traditional Chinese medicine and its preparations, has not been carried out.

Experimental Methods:
In this paper, a sensitive and specific ultra-high-performance liquid chromatographictandem
mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of eight
potential Q-markers of ZSTG, including timosaponin A3, berberine, jatrorrhizine, phellodendrine, palmatine, mangiferin,
neomangiferin, and timosaponin BII. A Kromasil 100-3.5 C18 column was used with a mobile phase of 0.2%
formic acid with acetonitrile, and gradient elution at a flow rate of 0.2 mL/min was achieved in 13 minutes and used
for separation. Detection was performed in positive/negative mode with multiple reaction monitoring (MRM).

Results:
The analytical method was validated in terms of the sensitivity, linearity, accuracy, precision, repeatability,
stability and recovery. The method established here was successfully applied to study the potential Q-markers in 8
batches of commercial samples, which demonstrated its use in improving the quality control of ZSTG.

Conclusion:
The developed method had high repeatability and accuracy and was suitable for the simultaneous analysis
of multiple Q-markers, which may provide a new basis for the comprehensive assessment and overall quality
control of ZSTG.
Rapid Anti-Depressant Relief by Ketamine: Exploring A Complex Mechanism of Action
Authors: Blum Kenneth , Pappas Todd C. , Clifton Bryan , Baron David , Madigan Margaret A. , Lott Lisa , Moran Mark , Clifton Cannon , Worrich Scott , Clarke Ervey , Boyett Brent , Bowirrat Abdalla , Gold Mark S. 
Published: August 2019

Background:
Suicide rates and narcotic overdose have doubled since 2000.
At least 30 percent of people with major depression are Treatment-Resistant (TR) and
require novel therapeutics. ketamine at low doses has been shown in clinical trials to
induce a rapid, short-lived anti-suicide and anti-depressant effect.

Objective:
To review the potential mechanism of action of ketamines’ alleviation of
depressive symptoms from both animal and available human literature.

Methods:
This is a synthesis of information from papers listed in PUBMED Central.
Although not exhaustive, this review highlights the most compelling work in the field
related to this remarkable clinical rapid anti-depressant effect.

Results:
While there have been several theories and with some scientific evidence to
date, the conclusion here is that currently, an exact and acceptable mechanism of
action (MOA) for ketamines’ rapid anti-depressant effect is not apparent. The MOA of
this compound with psychoactive abuse potential at a higher dosage and acute antidepressive
effect in the most resistant patients is unknown.

Discussion:
Possible MOAs reviewed, include dopamine receptor modulation through
epigenetic neuroadaptation via specific D1/D2 antagonism, D1 activation using optogenetic
stimulation, and the role of D2/D3 availability in the ketamine therapeutic action.

Conclusion:
Unraveling MOA could guide the development of other unique Psychoplastogens
capable of rapidly promoting structural and functional neural plasticity in
cases of TR Major Depressive Episodes (MDE) and unipolar Major Depression Disorder
(MDD).
PENDIDIKAN DI INDONESIA MEMPRIHATINKAN
Authors: Sujarwo Sujarwo 
Published: August 2019

Pendidikan adalah hal pokok yang akan menopang kemajuan suatu bangsa. Kemajuan suatu bangsa dapat diukur dari kualitas dan sistem pendidikan yang ada. Tanpa pendidikan, suatu negara akan jauh tertinggal dari negara lain. Kualitas pendidikan di Indonesia pada dewasa ini sangat memprihatinkan. Ini dibuktikan di antaranya oleh data UNESCO (2000) tentang peringkat Indeks Pengembangan Manusia (Human Development Index), yaitu komposisi dari peringkat pencapaian pendidikan, kesehatan, dan penghasilan per kepala yang menunjukkan bahwa indeks pengembangan manusia Indonesia makin menurun. Di antara 174 negara di dunia, Indonesia menempati urutan ke-102 pada 1996, ke-99 pada 1997, ke-105 pada 1998, dan ke-109 pada 1999. Selain itu, bukti nyata dari kemerosotan pendidikan di Indonesia adalah terjadinya tawuran, tingkat pelajar maupun mahasiswa. Aksi tawuran yang biasanya dipicu masalah sepele, dampaknya sangatlah besar. Masyarakat di seluruh dunia akan menyaksikan lewat media cetak maupun elektronik amburadulnya pendidikan di Indonesia.
Clinical Outcomes of Pneumonia and Other Comorbidities in Children Aged 2-59 Months in Lilongwe, Malawi: Protocol for the Prospective Observational Study “Innovative Treatments in Pneumonia”
Authors: Ginsburg Amy Sarah , May Susanne , Nkwopara Evangelyn , Ambler Gwen , McCollum Eric D , Mvalo Tisungane , Phiri Ajib , Lufesi Norman 
Published: August 2019

Background
Pneumonia is the leading infectious cause of death worldwide among children below 5 years of age. Clinical trials are conducted to determine optimal treatment; however, these trials often exclude children with comorbidities and severe illness.

Conclusions
Given the paucity of data from Africa, African-based research is necessary to establish optimal management of childhood pneumonia in malaria-endemic settings in the region. An expanded evidence base that includes children with pneumonia and other comorbidities, who are at high risk for mortality or have other complications and are therefore typically excluded from childhood pneumonia clinical trials, can contribute to future iterations of the World Health Organization Integrated Management of Childhood Illness guidelines.

Methods
The study enrolled 1000 children with pneumonia presenting to the outpatient departments of Kamuzu Central or Bwaila District Hospitals in Lilongwe, Malawi, who were excluded from concurrent randomized controlled clinical trials investigating fast breathing and chest indrawing pneumonia and who met the inclusion criteria for this prospective observational study. Each child received standard care for their illnesses per Malawian guidelines and hospital protocol and was prospectively followed up with scheduled study visits on days 1, 2 (if hospitalized), 6, 14 (in person), and 30 (by phone). Our primary objectives are to describe the clinical outcomes of children who meet the inclusion criteria for this study and to investigate whether the percentages of children cured at day 14 among those with either fast breathing or chest indrawing pneumonia and comorbidities such as severe malaria, anemia, severe acute malnutrition, or HIV are lower than those in children without these comorbidities in the standard care groups in concurrent clinical trials. This study was approved by the Western Institutional Review Board, Malawi College of Medicine Research and Ethics Committee, and the Malawi Pharmacy, Medicines and Poisons Board.

Objective
This prospective observational study aimed to assess the clinical outcomes of children aged 2-59 months with both pneumonia and other comorbidities in a malaria-endemic region of Malawi.

Results
The Innovative Treatments in Pneumonia project was funded by the Bill and Melinda Gates Foundation (OPP1105080) in April 2014. Enrollment in this study began in 2016, and the primary results are expected in 2019.

International Registered Report Identifier (IRRID)
DERR1-10.2196/13377
Childrens' and Parents' Willingness to Join a Smartphone-Based Emergency Response Community for Anaphylaxis: Survey
Authors: Khalemsky Michael , Schwartz David G , Silberg Tamar , Khalemsky Anna , Jaffe Eli , Herbst Raphael 
Published: August 2019

Background
Medical emergencies such as anaphylaxis may require immediate use of emergency medication. Because of the low adherence of chronic patients (ie, carrying anti-anaphylactic medication) and the potentially long response time of emergency medical services (EMSs), alternative approaches to provide immediate first aid are required. A smartphone-based emergency response community (ERC) was established for patients with allergies to enable members to share their automatic adrenaline injector (AAI) with other patients who do not have their AAI at the onset of anaphylactic symptoms. The community is operated by a national EMS. In the first stage of the trial, children with food allergies and their parents were invited to join.

Objective
This study aimed to identify the factors that influence the willingness to join an ERC for a group of patients at risk of anaphylaxis.

Methods
The willingness to join an ERC was studied from different perspectives: the willingness of children with severe allergies to join an ERC, the willingness of their parents to join an ERC, the willingness of parents to enroll their children in an ERC, and the opinions of parents and children about the minimum age to join an ERC. Several types of independent variables were used: demographics, medical data, adherence, parenting style, and children's autonomy. A convenience sample of children and their parents who attended an annual meeting of a nonprofit organization for patients with food allergies was used.

Results
A total of 96 questionnaires, 73 by parents and 23 by children, were collected. Response rates were approximately 95%. Adherence was high: 22 out of 23 children (96%) and 22 out of 52 parents (42%) had their AAI when asked. Willingness to join the community was high among parents (95%) and among children (78%). Willingness of parents to enroll their children was 49% (36/73). The minimum age to join an ERC was 12.27 years (SD 3.02) in the parents’ opinion and 13.15 years (SD 3.44) in the children’s opinion.

Conclusions
Parents’ willingness to join an ERC was negatively correlated with parents’ age, child’s age, and parents’ adherence. This can be explained by the free-rider effect: parents who carried an AAI for their young child, but had low adherence, wanted to join the ERC to get an additional layer of emergency response. Children’s willingness to join the community was positively correlated with age and negatively correlated with the child’s emotional autonomy. Parents’ willingness to enroll their children in an ERC was positively correlated with child’s age and negatively correlated with parents’ adherence: again, this can be explained by the aforementioned free-rider effect. Parents’ and children’s opinions about the minimum age to join an ERC were negatively correlated with protective parenting style and positively correlated with monitoring parenting style.
Monitoring of Vedolizumab Infusion Therapy (MOVE-IT) Response With Fecal Inflammation Markers, Ultrasound, and Trough Serum Level in Patients With Ulcerative Colitis: Protocol for a Multicentric, Prospective, Noninterventional Study
Authors: Cording Jimmi , Blömacher Margit , Wiebe Berit Inga , Langhorst Jost , Kucharzik Torsten , Sturm Andreas , Schreiber Stefan , Helwig Ulf 
Published: August 2019

Background
Vedolizumab has been shown to induce clinical remission in patients with active ulcerative colitis. Treatment with anti-integrin vedolizumab leads to clinical remission in 16.9% and clinical response in 47.1% of cases after 6 weeks. However, in clinical practice, no decision to discontinue or continue vedolizumab therapy is made until 14 weeks at the earliest.

Objective
The aim of this study is to develop an algorithm for optimizing vedolizumab administration in patients with moderate-to-severe ulcerative colitis by calculating the probability of clinical response at week 14, on the basis of the data from week 6.

Methods
This is a prospective, single-arm, multicentric, noninterventional, observational study with no interim analyses and a sample size of 35 evaluable patients.

Results
The enrollment started in August 2018 and was still open at the date of submission. The study is expected to complete in September 2020.

Conclusions
The early identification of patients who are responding to an integrin antibody is therapeutically beneficial. At the same time, patients who are not responding can be identified earlier. The development of a therapeutic algorithm for identifying patients as responders or nonresponders can thus help prescribing physicians avoid ineffective treatments and stop these very early.
Familia Chironomidae (Orden Díptera) utilizada como bioindicador para la determinación de calidad ambiental de la cuenca del Río Gallegos (Santa Cruz, Argentina)
Authors: Sierpe Carolina , Sunico Alejandro 
Published: August 2019

Estudios previos realizados en la región, utilizando la comunidad de macroinvertebrados bentónicos y aplicando índices bióticos a nivel taxonómico de órdenes y familias, permitieron determinar la existencia de procesos de impacto antrópico y degradación en los ambientes acuáticos de la cuenca. Estos estudios, pusieron en evidencia la necesidad de trabajar a niveles taxonómicos más precisos, abarcando la identificación a nivel de género y especie de algunos de los organismos predominantes en la comunidad bentónica. En función de esto, uno de los objetivos de la presente beca es caracterizar la fauna de insectos quironómidos (Díptera, Chironomidae) para la estación otoño, empleando las técnicas aprendidas para la determinación taxonómica a nivel de género. La información obtenida permitirá ajustar y mejorar la eficiencia de los índices bióticos de calidad ambiental, diseñados y adaptados para el diagnóstico y monitoreo en ambientes acuáticos de la región.En este trabajo se procesaron 28 muestras de acroinvertebrados bentónicos de 7 sitios de muestreo localizados sobre la cuenca superior del río Gallegos. Estas muestras se tomaron en mayo de 2017 y corresponden a la estación de otoño. Se identificaron un total de 10 géneros de insectos quironómidos, de los cuales 5 pertenecen a la subfamilia Orthocladiinae, 2 de Tanypodinae y 3 de Chironominae.
Bookkeeper-Controller-CFO: The Rise of the Chief Financial and Chief Accounting Officer
Authors: Doron Michael , Baker C. Richard , Zucker Kiren Dosanjh 
Published: August 2019

ABSTRACT
This paper traces the evolution of the chief accounting and chief financial officers from minor figures in corporate governance for most of the 20th century to senior management positions by the late 1970s. The paper begins with the testimony before Congress of Arthur Tucker during the debates over the legislation that would become the 1933 Securities Act. Tucker's testimony resulted in the controller or chief accounting officer being included among those persons specifically listed as potentially liable for fraudulent statements or omissions under Section 11 of the Act. The impact of Tucker's efforts, the evolution of the legal liability of financial and accounting officers over the next several decades, the increasing complexity of corporate finance and financial reporting that led to the establishment of the CFO as a position second only to the CEO, and the place of the accounting officer among senior management, are analyzed in the subsequent sections.
REVITALISASI TATA RIAS PENGANTIN KERATON SUMENEP (PENGEMBANGAN MATERI MATA KULIAH TATA RIAS PENGANTIN INDONESIA)
Authors: Asnawi Shofiyah Fauzi 
Published: August 2019

Jenis penelitian kualitatif pendekatan etnografi. Tujuan penelitian memberikan catatan dan dokumentasi atas bentuk dan makna tata rias pengantin Keraton, Sumenep Legha. Rias wajah pengantin wanita menggunakan conda’ dan godhek. Keduanya menggunakan kaco’ di dahi dan sanggul malang yang dihias rangkaian bunga (Rambai ganggung, rengpereng dan Tongcontong/duk remmek) dan aksesoris (Peces, Jamang, Soroy/ jungkat, dan Coconduk/Cunduk Mentul). Busana pengantin wanita Legha/kemben, dan Sarong songket/samper bine, Odhet, Sabbu’ dan Rape’, perlengkapannya selop. Busana pengantin laki-laki Celana Lake, Rape’, Lok elokan dan Sabbu’, perlengkapannya selop dan keris dihias to’or. Keduanya menggunakan bunga buntal di bagian pinggang. Perhiasan kedua pengantin: Kalung Kalamangga (Kolomonggo), Klap Bahu dan Ghelleng. Pada kuping pengantin perempuan menggunakan Kerabu/Anting-anting. Pengantin laki-laki menggunakan Puspa Karma (Jangoleng) di kupingnya dan Renteng Melati di bahu.Tata rias wajah dan rambut pada pengantin pria memiliki kesan gagah (seorang raja), pengantin putri berkesan cantik dan anggun (ratu). Tampilan busana dan perhiasan memiliki makna religis dan simbol-simbol pengakuan kebesaran, kemurahan dan pengharapan/doa-doa untuk sepasang pengantin kepada Tuhan Yang Maha Esa