bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endothelial Progenitor Cells at the Interface of Chronic Kidney Disease: From Biology to Therapeutic Advancement
Authors: Coppolino Giuseppe , Cernaro Valeria , Placida Giordano , Leonardi Giuseppe , Basile Giorgio , Bolignano Davide 
Published: November 2018

Background:
The ‘epidemic’ diffusion of chronic kidney disease (CKD) needs
the development of new therapeutic approaches to slow down the progression to end-stage
renal disease. Endothelial Progenitor Cells (EPCs) are promising tools for the treatment of
many human diseases as they promote the repair of damaged tissues. They were also suggested
as therapy to repair renal tissue after an injury. Strategies using EPCs to induce a reparative
process with functional restoring of a diseased kidney or to delay CKD are of two
types: direct stem cells infusion or stimulating endogenous release of EPCs. The repair
process following endothelial damage occurs in three steps: 1) mobilization from bone marrow;
2) homing on the sites of vascular injury; 3) incorporation of the endothelium into the
injured blood vessels.
<P>
Objective: In this narrative review we pointed our view to the role of EPCs in endothelial
repair and the potential in retarding the progression to renal function loss.
<P>
Conclusions: Physicians need the development of new preventive strategies for detecting
patients at risk and discover renal damage. In this way they could slow, by a conservative
therapy, the evolution of renal disease and decrease associated morbidity. EPCs have instead
well recognized reparative capabilities in many organs. We summarized some recent preclinical
and clinical models of EPCs mobilization during CKD and we emphasized the potential
use of EPCs to slow the progression of renal disease.
Anti-Arthritic Effect of Garcinol Enriched Fraction Against Adjuvant Induced Arthritis
Authors: Warriar Purnima , Barve Kalyani , Prabhakar Bala 
Published: November 2018

Background:
Garcinia indica also known as kokum is used in traditional system of medicine
for relieving inflammation and rheumatic pain. Garcinol, a benzophenone obtained from its fruit
rind is reported to have anti-inflammatory effect via modulating arachidonic acid metabolism, suppressing
iNOS expression, NF-κB activation and COX-2 expression. It has also been studied for antioxidant
and anticancer activity. Apart from these, few patents claim that garcinol also has anti-obesity and hepatoprotective
effect and has a potential to be used for the treatment of renal disorders, endometriosis
and cardiac dysfunction.

Objective:
Garcinol Enriched Fraction (GEF) from the fruit rind of Garcinia indica should be effective
in the treatment of arthritis, one of the chronic inflammatory disorder owing to its anti-inflammatory
property as indicated by earlier experiments.

Methods:
GEF was prepared from the fruit rind of Garcinia indica and quantified using LC-MS/MS. It
was found to contain 89.4% w/w of garcinol. GEF was evaluated at the dose of 10mg/kg for its efficacy
against Complete Freund’s Adjuvant (CFA) induced arthritis in Wistar albino rats. Paw volumes of
both sides were measured by Plethysmometer and body weight was recorded on 0, 1, 5, 12 and 21st day.
The hyperalgesic response was also measured by motility test and stair climbing test.

Results:
GEF showed a significant reduction in paw swelling (p < 0.0001) and arthritis index (p <
0.0001) exhibiting anti-inflammatory potential. It also improves the motility and stair climbing ability
of experimental animals (p < 0.05), thus reducing hyperalgesia.

Conclusion:
Garcinol enriched fraction shows anti-arthritic activity in experimental animals.
Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies – Review of Case Studies
Authors: Giri Poonam , Patel Harilal , Srinivas Nuggehally R. 
Published: November 2018

Background:The cocktail approach of probing drug metabolizing enzymes, in particular cytochrome P450 (CYP) enzymes, is a cornerstone in clinical pharmacology studies. The first report of the famous “Pittsburg cocktail” has led the way for the availability of numerous cocktail substrate mixtures that provide options for indexing of CYP enzymes and/or evaluating the perpetrator capacity of the drug.Objective:The key objectives were: 1) To collate, tabulate, and discuss the various cocktail substrates to determine specific CYP enzyme activity in clinical pharmacology studies with specific case studies; 2) To introspect on how the cocktail approach has withstood the test of time and evolved for enabling key decision(s); 3) To provide some futuristic views on the use of cocktail in drug discovery and development.Method:The review was compiled after consultation with databases such as PubMed (NCBI database) and Google scholar to source various published literature on cocktail approaches in drug development.Results:In the reviewed case studies, CYP indexing was achieved using a single time point (differing for specific CYP enzyme) plasma determination of the metabolite to parent ratio for all CYP enzymes with the exception of CYP3A4/5, where multiple time points were required for exposure measurement of midazolam and its metabolite. Likewise, a single void of urine, for a specific time duration, has been utilized for the recovery measurements of parent and metabolite for CYP indexing purposes.Conclusion:The review provides a comprehensive list of various types of cocktail approaches and discusses some key considerations including the evolution of the cocktail approaches over time, perspectives and futuristic views for the use of probe drugs to aid the execution of clinical pharmacology studies and data interpretation.
Магнитная восприимчивость и спиновые флуктуации в несверхпроводящей фазе PuCoGa-=SUB=-5-=/SUB=-
Authors: Волков А.Г. , Повзнер А.А. 
Published: November 2018

AbstractWithin the Hubbard model with allowance for Hund’s and spin–orbit interactions, the concepts of thermal spin fluctuations in a strongly correlated system of f electrons in PuCoGa_5 are developed. The effect of fluctuations of the spin magnetic moments of different orbitals on the spin–orbit splitting of the f electron spectrum is considered. The mean square magnetic moment obtained in this case makes it possible to describe the observed temperature dependence of the magnetic susceptibility (χ( T )) of PuCoGa_5 near and above the electron pairing temperature. Estimates of the radius of spin correlations correspond in order of magnitude to the sizes of Cooper pairs in superconductors with the d symmetry of the order parameter. In the high-temperature region, the magnetic susceptibility obeys the Curie–Weiss law. With decreasing temperature, when approaching the pairing temperature, the ferromagnetic instability is suppressed and the temperature maximum of χ( T ) appears.
MENINGKATKAN DAYA BERKECAMBAH BENIH SELEDRI (Apium Graviolens) DENGAN INVIGORASI
Authors: Surtinah Surtinah , Susi Neng , Endriani Endriani 
Published: November 2018

<p>Tujuan penelitian ini adalah untuk mendapatkan jenis larutan perendam yang dapat menghasilkan kecambah seledri yang terbaik.Penelitian ini dilakukan secara eksperimen dengan rancangan lingkungan acak lengkap, dan rancangan perlakuan adalah perendaman dalam air biasa, perendaman dengan menggunakan air dengan suhu 60<sup>0</sup>C, perendaman dengan menggunakan Gibgrow, perendaman dengan zpt Atonik, dan perendaman dengan Hormon Tanaman Unggulan. pengamatan dilakukan terhadap Viabilitas benih , Kecepatan berkecambah, Tinggi kecambah, Kecepatan tumbuh , dan Panjang Akar. Hasil penelitian diperoleh, perendaman menggunakan Gibrow menghasilkan kecambah seledri terbaikan lainnya.</p><p><em>The aim of this research is to get the best kind of marinade solution to produce the best celery sprouts. This experiment was conducted experimentally with complete randomized environmental design, and treatment design was immersion in plain water, immersion by using water with temperature 60</em><em> </em><em><sup>0</sup></em><em>C, immersion using Gibgrow, immersion with Atonic zpt, and immersion with </em><em>Hormon Tanaman Unggulan</em><em>. observations were made on seed viability, germination rate, sprout height, growing velocity, and Root Length. The result of this research is the best soybean seed immersion is soaking by using Gibrow compared with other treatment.</em><em></em></p>
Rekonstruksionisme: Metode Komunikatif Dalam Pemerolehan Dan Pembelajaran Bahasa Untuk Mengembangkan Kemampuan Berbahasa
Authors: Cahyani Isah , Hadianto Daris 
Published: November 2018

<p>Penelitian ini bertujuan untuk mengetahui fenomena berbahasa Indonesia pada peserta didik, bagaimana pandangan rekonstruksionisme dan peran metode komunikatif dalam mengembangkan kemampuan berbahasa pada peserta didik. Metode penelitian yang penulis gunakan adalah metode penelitian kualitatif. Metode penelitian kualitatif yang bersifat deskriptif dilakukan dengan teknik. Adapun hasil dari penelitian ini, yaitu peserta didik masih kesulitan menggunakan bahasa Indonesia yang baik dan benar pada situasi formal. Hal ini tidak terlepas dari pemerolehan dan pembelajaran bahasa yang diperoleh peserta didik sebelumnya. Dengan berpijak pada teori rekonstruksionisme dan metode komunikatif, peserta didik dapat memperoleh dan menggunakan suatu bahasa dengan baik jika bahasa itu sering digunakan atau bersifat komunikatif. Hal ini mengimplikasikasikan bahwa seseorang dapat membangun kemampuan berbahasa dari pengalaman-pengalaman yang diperolehnya, artinya peserta didik harus sering mengalami atau menggunakan bahasa tersebut. Adapun peran dari metode komunikatif itu sendiri, yaitu meningkatkan atau mengembangkan kemampuan berbahasa peserta didik. Peran sekolah dan guru adalah mendorong anak untuk menggunakan bahasa-bahasa tersebut dengan mencipatakan situasi-situasi tertentu (situasi komunikatif) agar kemampuan berbahasa peserta didik berkembang dengan baik, baik itu berbahasa Indonesia maupun berbahasa Asing.</p><p><em>This study aims to find out the phenomenon of Indonesian language in learners, how the views of reconstructionism and the role of communicative methods in developing language skills in learners. The research method that I use is qualitative research method. Descriptive qualitative research method is done by technique. The results of this study, namely learners are still difficult to use the Indonesian language is good and true in the formal situation. This can not be separated from the acquisition and learning of language obtained by previous learners. Based on the theory of reconstructionism and communicative methods, learners can acquire and use a language well if the language is often used or communicative. This implies that a person can build the language skills of the experiences he / she obtains, meaning that learners should often experience or use the language. The role of the communicative method itself, which is to improve or develop the language skills of learners. The role of schools and teachers is to encourage children to use these languages by creating specific situations (communicative situations) so that the language skills of learners develop well, be it Indonesian-speaking or foreign languages. </em></p>
Fasiglifam-Induced Liver Injury in Patients With Type 2 Diabetes: Results of a Randomized Controlled Cardiovascular Outcomes Safety Trial
Authors: Menon Venu , Lincoff A. Michael , Nicholls Stephen J. , Jasper Susan , Wolski Kathy , McGuire Darren K. , Mehta Cyrus R. , Rosenstock Julio , Lopez Claudia , Marcinak John , Cao Charlie , Nissen Steven E. 
Published: November 2018

OBJECTIVE
To evaluate the cardiovascular (CV) safety of fasiglifam, a first-in-man G-protein–coupled receptor 40 (GPR40) agonist, in patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS
A phase 3 multicenter randomized double-blind placebo-controlled two-arm trial was intended to randomize 5,000 participants with type 2 diabetes at high CV risk to fasiglifam or placebo. The primary objective of the trial was to rule out an upper noninferiority bound &gt;1.3 for a one-sided 97.5% confidence limit of the hazard ratio (HR) for CV composite events during treatment with fasiglifam compared with placebo. The primary outcome was the time to first occurrence of any component of the major adverse CV event composite of CV death, nonfatal myocardial infarction, nonfatal stroke, and hospitalization for unstable angina.

RESULTS
The study enrolled 3,207 participants but was terminated because of liver safety concerns. Increased rates of liver enzyme elevation (AST/ALT ≥3–5 × upper limit of normal [ULN]) with fasiglifam were observed. The incidence of ALT or AST ≥3 × ULN with fasiglifam compared with placebo was 2.1% vs. 0.5%, P &lt; 0.001, and the incidence for ≥10 × ULN was 0.31% vs. 0.06%, P &lt; 0.001. A primary CV composite outcome occurred in 40 participants, 2.5% each in the fasiglifam and placebo arms at 12 months (HR 1.05; 95% CI 0.67, 1.63).

CONCLUSIONS
Development of fasiglifam was terminated due to concerns of drug-induced liver injury. Performance of a U.S. Food and Drug Administration–mandated CV outcomes trial supported the termination of the fasiglifam clinical program.
An initial study in the development of smartphone addiction scale for student (SAS-S)
Authors: Habibi A Maulani , Sanyata Sigit 
Published: November 2018

The purpose of this study was to develop a new scale, Smartphone addiction scale for Student (SAS-S) was developed to measure the level of smartphone addiction in high school students. A total of 32 item scales were developed through literature studies. Exploratory factor analysis (EFA) is used to examine the structure of factors formed in this scale. The results show the Smartphone addiction scale for Student (SAS-S) has 22 good items from 6 factor structures that are formed, including: (1) Self Control Disorder, (2) loss of time, (3) sleep disturbances, (4) can not be without smartphones, (5) changes in feelings and, (6) concerned smartphone. SAS-S is a good scale that can be used by any high school student. Another point also shows that the scale of smartphone addiction for high school students has a strong level of validity and reliability.
Issues of qualification of crimes against life and health
Authors: Artyushina Olga 
Published: November 2018

The subject. The key and, in the author's opinion, the most interesting questions of thequalification of intentional crimes for life and health are determined in a strategic waybased on the study of scientific literature and materials of judicial practice, as well as monitoringof contemporary reality.The purpose of the paper is to investigate the problems of redundancy and the gap in thecriminal law in this area, as well as the difficulties in applying the relevant norms, takinginto account the recommendations of the Plenum of the Supreme Court of the Russian Federation.The methodological basis of the work is dialectical-materialistic, logical, historical, systemstructural,as well as comparative-legal and concrete sociological methods.The main results and scope of it’s application. It is proposed to decriminalize the beatingsprovided for in Art. 116 of the Criminal Code of the Russian Federation, with the introductionof appropriate changes to the version of Article 116.1 of the Criminal Code of the RussianFederation. The problem of an absolute gap in the field of criminal and legal protectionof the individual from new types of causing death and involving minors in a suicidal behaviorpattern, including using the Internet, is being raised. A draft of Federal Law No. 118634-7,submitted by I.A. Yarovaya in March 2017, is overviewed and practical recommendationsfor improving the criminal legislation of Russia are formulated.Conclusions. After the analyzing the most difficult cases of competition, the conclusion isbased on the decisive significance of the expert's conclusion about the presence or absenceof affect for the qualification of these crimes. In order to avoid a superficial approach to lawenforcement and, as a consequence, judicial errors, it is proposed to oblige the courts ineach case, when establishing relevant facts, to appoint a forensic expert examination tocheck whether the perpetrator has a sudden violent emotional excitement (affect).
To the admissibility of the civil law exemption of property from arrest, imposed in the criminal proceedings: domestic and foreign experience
Authors: Kashtanova Natalia 
Published: November 2018

The subject of paper deals with the legal nature of measures of criminal procedural compulsionin the form of seizure of property.Methodological basis of the article is based on general scientific dialectical methods of cognitionof objective reality of the legal processes and phenomena that allowed us to conduct anobjective assessment of the state of legislation and law enforcement practice in the proceduralaspects of the cancellation of the seizure of property in criminal proceedings of Russia.The results and scope of it’s application. It is submitted that the cancellation of the seizureof the property (or the individual limit) is allowed only on the grounds and in the mannerprescribed by the criminal procedure law of the Russian Federation. However, the studyfound serious contradictions in the application of the relevant law. In particular, cases inwhich the question of exemption of property from arrest (exclusion from the inventory),imposed in the criminal case was resolved in a civil procedure that, in the opinion of theauthor of the publication, is extremely unacceptable.On the stated issues topics analyzes opinions of scientists who say that the dispute aboutthe release of impounded property may be allowed in civil proceedings, including pendingresolution of the criminal case on the merits. The author strongly disagrees with this positionand supports those experts who argue that the filing of a claim for exemption of propertyfrom arrest (exclusion from the inventory) the reviewed judicial act of imposing of arrestwithout recognition per se invalid. In this regard, the author cites the legal position ofthe constitutional Court of the Russian Federation, from which clearly follows that of theright of everyone to judicial protection does not imply the possibility of choice of the citizenat its discretion, techniques and procedures of judicial protection, since the features of suchjudicial protection is defined in specific Federal laws.The author analyzes and appreciates Kazakhstan's experience of legal regulation of the permissibilityof filing a civil claim for exemption of property from seizure imposed in criminalproceedings. The author notes that the new civil procedural legislation of the Republic ofKazakhstan, which came into force from 01 January 2016, clearly captures that considerationin the civil proceedings are not subject to claims for exemption of property from seizureby the criminal prosecution body.Conclusions. Necessity of amendment to article 422 of the Civil Procedure Code of Russia:this article should not apply to cases of application of measures of criminal procedural compulsionin the form of seizure of property. Among other things, the author proposed additionsto part 9 of article 115 of the Criminal Procedure Code of Russia.
THREE MODELS OF NATIONAL CRIMINAL POLICY IN THE CONTEXT OF GLOBALIZATION
Authors: Kleymenov Ivan 
Published: November 2018

The author identifies three models of national criminal policy: the sovereign, reformist and experimental. The main criteria of such differentiation are the exposure to global influence, the criminological soundness and stability of criminal policy. Identification of the model of criminal policy in a particular state is a complex task that requires independent research.The subject. The article is devoted to modeling of the national criminal policy in modern conditions of globalization. The article discusses various models of criminal policy in the conditions of globalization.The purpose of the author is to describe the basic models of national criminal policy in modern conditions of globalization.The methodology. The author uses the method of analysis and synthesis, formal legal method as well as sociological methods (survey).The results, scope of application. The author identifies three models of national criminal policy: the sovereign, reformist and experimental. The main criteria of such differentiation are the exposure to global influence, the criminological soundness and stability of criminal policy. The sovereign model is based on doctrine of weak state and a strong combat criminal activity. It is distinguished by the pursuit of the realization of the equality of all before the law, criminal strategic and political planning system with a clear definition of goals and objectives; criminological security. The reform of criminal policy is characterized byuncertainty goals and objectives, utopianism and pretentiousness, dependence on standards of the international organization, the lower prestige of criminology, reduction of social programs, lobbying of group interests, permanent amendments to the criminal and criminal procedure legislation. Experimental model of criminal policy is connected with approbation of such technologies of management of society that are criminal and contrary to human experience in fighting crime.Conclusions. Criminal policy of the various states tends by globalist influence more or less. The desire for sovereignty in every sphere, including criminal justice, results the imposition of sanctions by the globalist structures. Reformist penal policy expresses the loss of a strategic, informed criminological development goals of criminal justice, and, as a rule, corresponds to the group, not the public interest. Experimental criminal policy demonstrates a high rate of development and takes a growing place in the globalist projects with an anti-Russian content.
SISTEM PENDUKUNG KEPUTUSAN DALAM MENENTUKAN PENILAIAN KINERJA GURU DENGAN METODE ANALYTICAL HIERARCHY PROCESS (AHP)
Authors: Rakasiwi Sindhu 
Published: November 2018

Kecanggihan teknologi seperti saat ini sangat dibutuhkan di berbagai bidang agar semua pekerjaan menjadi lebih efektif dan efesien. Teknologi seperti itupun dibutuhkan di dalam sekolah-sekolah agar pekerjaan menjadi lebih cepat, efektif dan efesien. Sekolah merupakan sebuah lembaga untuk pengajaran siswa atau murid di bawah pengawasan pendidik atau guru [1]. Salah satunya Sekolah Dasar Beji Ungaran. Kualitas pendidikan sangat diperlukan demi kemajuan sekolah. Dalam menjaga kualitas guru, sekolah secara rutin melakukan monitoring dan evaluasi kinerja guru, untuk memperoleh peningkatan kualitas guru. Di SD Beji dalam memonitoring kinerja guru masih mengalami mengalami kendala karena meningkatnya jumlah siswa dan terbatasnya pegawai dalam memonitoring prestasi guru. Analitycal Hierarchy Process(AHP) umumnya digunakan dengan tujuan untuk menyusun prioritas dari berbagai alternative pilihan yang ada dan pilihan-pilihan tersebut bersifat kompleks atau multikriteria [2]. Penentuan prioritas inilah yang merupakan bagian penting dari penggunaan metode AHP [3]. Pada dasarnya metode AHP merupakan suatu teori umum tentang suatu konsep pengukuran [3]. Metode ini digunakan untuk menemukan suatu skala rasio baik dari perbandingan pasangan yang bersifat diskrit maupun kontinu.Perbandingan-perbandingan ini dapat diambil dari ukuran aktual atau dari suatu skala dasar yang mencerminkan kekuatan perasaan dan prefensi relatif. Dengan penggunaan sistem ini diharapkan mampu memecah permasalahan pada SD Beji Ungaran. Sehingga dalam menentukan prestasi kinerja guru dapat lebih cepat, efektif,efisien dan lebih akurat.