bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Coronary Slow Flow Phenomenon: A Retrospective Study
Authors: V. Satish Kumar Rao , Garre Indrani 
Published: September 2019

Abstract
Aim This study aimed to analyze laboratory predictors, angiographic profile, clinical profile, and risk factors for coronary slow flow (CSF) phenomenon without coronary obstructive lesion in patients who came for a coronary angiogram.
Materials and Methods The case-control study consisted of patients who underwent coronary angiography and were divided into two groups: patients with coronary slow flow (case group, n = 100) and patients with the normal coronary flow (control group, n = 100). Coronary flow was studied using corrected thrombolysis in myocardial infarction frame count (CTFC). The slow flow was defined as CTFC beyond 2 standard deviations from the normal published range. Risk factors including age, sex, diabetes mellitus (DM), hypertension, dyslipidemia, smoking, body mass index (BMI), hematological and biochemical parameters (complete blood picture, platelet count, total and differential leucocyte count, platelet-to-lymphocyte ratio [PLR], neutrophil-to-lymphocyte ratio [NLR] and lipid profile) were assessed. In both groups, clinical information was collected, and laboratory parameters were measured and compared.
Results Patients with CSF were more likely to be male and active smokers. Total cholesterol, triglyceride, BMI, and DM were more commonly seen in the CSF group compared with the control group. Inflammatory markers like uric acid (p = 0.03) and high-sensitivity C-reactive protein (Hs-CRP) (p = 0.000) were found to be statistically significant. Hematocrit (p = 0.023), NLR (p = 0.001), total cholesterol (p = 0.000), triglycerides (p = 0.000), and BMI (p = 0.000) were statistically significant. PLR has the tendency of statistically significance (p = 0.059) BMI, total cholesterol, triglycerides, and Hs-CRP were strong predictors for CSF.
Conclusion CSF was common in males, smokers, DM patients, and it was associated with high NLR, uric acid, and Hs-CRP levels. The independent predictor of CSF was BMI, total cholesterol, triglycerides, and Hs-CRP levels. These findings provide an impetus for additional studies to confirm the role of other inflammatory markers in CSF patients and treatment strategies depending on that.
Uncommon Coronary Abnormalities in a Patient with Discoid Lupus Erythematosus
Authors: Valencia Damian , Linares Juan , Das Sulagna , Valencia Victor , Yatsynovich Yan 
Published: September 2019

AbstractA 43-year-old male presented with shortness of breath and palpitations. Physical examination was significant for skin lichenification, an erythematous maculopapular rash with annular plaques, a fissured tongue, and digital clubbing. Electrocardiogram captured a supraventricular tachycardia and right bundle branch block. Left heart catheterization found several proximal left coronary artery branch aneurysms, a right coronary–pulmonary artery fistula, venous–luminal vessels between the right heart chambers and cardiac veins, and thebesian venous lakes. Functional cardiac capacity was reduced, with left ventricular ejection fraction of 35 to 40%, on ventriculogram. A diagnosis of discoid lupus erythematosus was established after skin biopsies revealed systemic lupus erythematosus-like features but negative anti-nuclear, anti-Smith, anti-ds-deoxyribonucleic acid, anti-Ro, and anti-La antibodies. The case reported is unique, in that while our patient had pathologic electrophysiologic changes typically seen with autoimmune disease, the patient had many anatomical cardiac anomalies without atherosclerotic coronary disease. It is uncertain whether these findings are purely incidental or are related to an underlying genetic disorder.
Design of intelligent stereo garage system
Authors: Zhang Lin , Zhou Ke , Geerdes Dominik 
Published: September 2019

Abstract
With the rapid development of the city, the car has entered thousands of households, and the difficulty of parking in the city will bring inconvenience to the citizens. This paper takes a roadway-type stereoscopic garage (warehouse-type stereo garage) as the research object, with PLC and servo control technology as the core, supplemented by contactless card reader and mobile client technology, and develops design of Urban stereo garage system based on Internet+. Through the network communication between the stereo garage system and the mobile phone client, the remote garage information inquiry is realized, and the PLC is connected with the touch screen to perform, and data reading and writing data can be performed and the visual management of the stereo garage can be realized.
Pre-calibration method for concrete distributor based on laser sensor
Authors: Li Dong , Li Yang , Zhang Ke , Zhou Peng , Yu Wenda , Guo Jingjing 
Published: September 2019

Abstract
The initial positioning of concrete distributor in the distributor area is the primary issue that restricts the realization of automatic distribution, in the automation production of precast concrete components. Therefore, the automatic pre-calibration method of concrete distributor based on laser sensor is proposed. The method realizes the locating of the concrete distributor in the moving area by adding encoders on the driving motors of the distribution-big-cart and the distribution-small-cart. The side-mold on the bottom-mold-tray could be positioned through adding a laser sensor and combining the encoders information. Pre-calibration point of concrete distributor is determined by synthesizing the information of sensors. By the designed automatic pre-calibration method, the workload of the operator could be reduced, the automation level of the distributor could be improved, and the foundation for the realization of the subsequent automatic function is laid.
The research on intelligent RGV dynamic scheduling based on hybrid genetic algorithm
Authors: Wang Likang , Mu Yaya , Gao Hongmei , Men Rui 
Published: September 2019

Abstract
With the rapid development of automation, mechatronics, information technology and other fields, production and processing systems are constantly moving towards unmanned and intelligent development. The RGV rail-guided vehicle system integrates various high-new technologies and is widely used in modern processing systems. Compared with the circular RGV orbit system, the linear reciprocating RGV system adopts a linear orbit, which is not easy to be blocked during operation, but its scheduling response mechanism is not perfect enough, which makes the operation efficiency of the whole system low. Therefore, how to improve the response mechanism and the operational efficiency of the RGV intelligent processing system has become an important factor in prompting the rapid development of the modern intelligent processing industry.
In this paper, aiming at the intelligent linear reciprocating scheduling problem, the main influencing factors are analyzed according to the shortest distance priority response and the shortest completion time. Mathematical analysis and mathematical modeling are carried out and a rule-based genetic algorithm is designed to solve the problem. The algorithm of replacing the fixed parameters in the traditional genetic algorithm with the adaptive cross mutation probability, and improves the genetic algorithm’s tendency to fall into the local optimal solution.
The status and results from ProtoDUNE Single Phase
Authors: Spanu Maura 
Published: September 2019

Abstract
DUNE is a leading-edge, international experiment for neutrino science and proton decay. Its ambitious physics program requires a careful prototyping of the engineering solutions envisaged for the scale-up of the LArTPC technology, as well as a careful control of the systematics through the acquisition of a deep knowledge of the detector response and performances. ProtoDUNE is an an extensive prototype program developed at the European Research Center (CERN) Neutrino Platform facility with the aim to answer to all the open questions about DUNE design. The Single Phase prototype (ProtoDUNE SP) has been assembled between 2017 and 2018 and it successfully took its first beam data from a dedicated SPS tertiary line from September to November 2018.
Development of gas sensitivity model of nanocomposites based on the tin dioxide - silicon dioxide system
Authors: Averin I A , Pronin I A , Karmanov A A , Yakushova N D , Moshnikov V A , Antropova N V 
Published: September 2019

Abstract
A model of gas sensitivity of nanocomposites based on tin dioxide - silicon dioxide system is developed. The mechanisms of conductivity and chemoresistive response of composites are investigated. The parameters corresponding to the maximum sensitivity of SiO2-SnO2 films are determined as well.
Applications of vacuum rectification for energy optimization of the fractional facility of benzene and toluene
Authors: Kabirov V R , Gorlenkov D V , Feshchenko R Yu , Kochetkova E A , Silivanov M O 
Published: September 2019

Abstract
The article represents the possibility of the energy optimization of rectification facility of separation of benzene and toluene by using columns with circled energy flows. The modeling was conducted in Hysys environment using NRTL thermodynamic package. The modernization requires the vacuum in the benzene column to lower the temperature and increase the temperature difference between the top of the toluene and the bottom of the benzene column. The proposed technological configuration allows to significantly reduce the energy consumption in the form of heating steam and achieve a significant economic effect.
Formation of non-vertical mesa structures on 4H-SiC RIE method using silicone-organic mask coating
Authors: Serkov A V , Ilyin V A 
Published: September 2019

Abstract
The article discusses the possibility of using silicone lacquer as a masking coating when creating micro-dimensional mesa structures on the 4H-SiC surface using the reactive ion-plasma etching method. The etching process was carried out on a setup with an ICP plasma source. The experiments were performed with the aim of determining the dependence of the angle of inclination of the wall of the mesa structure on the parameters of the etching process. The etching results were recorded with a Helius nanolab instrument complex and a Quanta Inspec raster electron microscope.
Method for improving the quality of focusing in optical spectrometers used for the diagnosis of plasma spectra
Authors: Uhov A A , Gerasimov V A , Kostrin D K , Selivanov L M , Simon V A 
Published: September 2019

Abstract
As a recording element in spectrometers with an optical scheme built on the Rowland circle, as a rule, a multi-element photodetector is used. Such a receiver has a flat surface and therefore the best focusing can be achieved at no more than two points. As a result of the research it was proposed to overcome this drawback by mounting a fiber-optic plate of a special design on the surface of a multi-element photodetector, which allows to obtain the best focus on the entire field of radiation detection, or to eliminate dead zones in multi-channel spectrometers.
Vacuum-semiconductor hybrid photoelectric device for near IR-region
Authors: Zubkov V I , Mironov D E , Solomonov A V 
Published: September 2019

Abstract
Results of the development of a hybrid vacuum semiconductor photodetector for the near IR-range are presented. The device is based on InP/In0.53Ga0.47As/InP photocathode and electron-sensitive CCD matrix with the number of elements 768×580. In order for the minority charge carriers generated within 0.5 μm from the surface to reach the recording cells, the CCD matrix was thinned to about 30 μm. In addition, in the reverse side of the matrix the phosphorus impurity was implanted. This technique creates the necessary gradient of the electric field, which provides high efficient transport of minority charge carriers to the potential pits of the CCD matrix. At room temperature and continuous irradiation the measured threshold irradiance was registered at the level of 5·10−8 W/cm2 for the wavelength range λ = 1–1.5 μm.
Invited Commentary: The Disillusionment of Developmental Origins of Health and Disease (DOHaD) Epidemiology
Authors: Gilman Stephen E , Hornig Mady 
Published: September 2019

Abstract
The developmental origins of health and disease (DOHaD) model promises a greater understanding of early development but has left unresolved the balance of risks and benefits to offspring of medication use during pregnancy. Masarwa et al. (Am J Epidemiol. 2018;187(8):1817–1827) conducted a meta-analysis of the association between in utero acetaminophen exposure and risks of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). A challenge of meta-analyzing results from observational studies is that summary measures of risk do not correspond to well-defined interventions when the individual studies adjusted for different covariate sets, which was the case here. This challenge limits the usefulness of observational meta-analyses for inferences about etiology and treatment planning. With that limitation understood, Masarwa et al. reported a 20%–30% higher risk of ADHD and ASD following prenatal acetaminophen exposure. Surprisingly, most of the original studies did not report diagnoses of ADHD or ASD. As a result, their summary estimates of risk are not informative about children’s likelihood of ADHD and ASD diagnoses. The long-term promise of DOHaD remains hopeful, but more effort is needed in the short-term to critically evaluate observational studies suggesting risks associated with medications used to treat conditions during pregnancy that might have adverse consequences for a developing fetus.
Biogenesis mechanisms of circular RNA can be categorized through feature extraction of a machine learning model
Authors: Liu Chengyu , Liu Yu-Chen , Huang Hsien-Da , Wang Wei 
Published: September 2019

Abstract

Motivation
In recent years, multiple circular RNAs (circRNA) biogenesis mechanisms have been discovered. Although each reported mechanism has been experimentally verified in different circRNAs, no single biogenesis mechanism has been proposed that can universally explain the biogenesis of all tens of thousands of discovered circRNAs. Under the hypothesis that human circRNAs can be categorized according to different biogenesis mechanisms, we designed a contextual regression model trained to predict the formation of circular RNA from a random genomic locus on human genome, with potential biogenesis factors of circular RNA as the features of the training data.

Results
After achieving high prediction accuracy, we found through the feature extraction technique that the examined human circRNAs can be categorized into seven subgroups, according to the presence of the following sequence features: RNA editing sites, simple repeat sequences, self-chains, RNA binding protein binding sites and CpG islands within the flanking regions of the circular RNA back-spliced junction sites. These results support all of the previously reported biogenesis mechanisms of circRNA and solidify the idea that multiple biogenesis mechanisms co-exist for different subset of human circRNAs. Furthermore, we uncover a potential new links between circRNA biogenesis and flanking CpG island. We have also identified RNA binding proteins putatively correlated with circRNA biogenesis.

Availability and implementation
Scripts and tutorial are available at http://wanglab.ucsd.edu/star/circRNA. This program is under GNU General Public License v3.0.

Supplementary information
Supplementary data are available at Bioinformatics online.
Impact of the Introduction of Rotavirus Vaccine on Hospital Admissions for Diarrhea Among Children in Kenya: A Controlled Interrupted Time-Series Analysis
Authors: Otieno Grieven P , Bottomley Christian , Khagayi Sammy , Adetifa Ifedayo , Ngama Mwanajuma , Omore Richard , Ogwel Billy , Owor Betty E , Bigogo Godfrey , Ochieng John B , Onyango Clayton , Juma Jane , Mwenda Jason , Tabu Collins , Tate Jacqueline E , Addo Yaw , Britton Tuck , Parashar Umesh D , Breiman Robert F , Verani Jennifer R , Nokes D James 
Published: September 2019

Abstract

Background
Monovalent rotavirus vaccine, Rotarix (GlaxoSmithKline), was introduced in Kenya in July 2014 and is recommended to infants as oral doses at ages 6 and 10 weeks. A multisite study was established in 2 population-based surveillance sites to evaluate vaccine impact on the incidence of rotavirus-associated hospitalizations (RVHs).

Methods
Hospital-based surveillance was conducted from January 2010 to June 2017 for acute diarrhea hospitalizations among children aged &lt;5 years in 2 health facilities in Kenya. A controlled interrupted time-series analysis was undertaken to compare RVH pre– and post–vaccine introduction using rotavirus-negative cases as a control series. The change in incidence post–vaccine introduction was estimated from a negative binomial model that adjusted for secular trend, seasonality, and multiple health worker industrial actions (strikes).

Results
Between January 2010 and June 2017 there were 1513 and 1652 diarrhea hospitalizations in Kilifi and Siaya; among those tested for rotavirus, 28% (315/1142) and 23% (197/877) were positive, respectively. There was a 57% (95% confidence interval [CI], 8–80%) reduction in RVHs observed in the first year post–vaccine introduction in Kilifi and a 59% (95% CI, 20–79%) reduction in Siaya. In the second year, RVHs decreased further at both sites, 80% (95% CI, 46–93%) reduction in Kilifi and 82% reduction in Siaya (95% CI. 61–92%); this reduction was sustained at both sites into the third year.

Conclusions
A substantial reduction in RVHs and all-cause diarrhea was observed in 2 demographic surveillance sites in Kenya within 3 years of vaccine introduction.
Intensive blood pressure lowering in different age categories: insights from the Systolic Blood Pressure Intervention Trial
Authors: Byrne Christina , Pareek Manan , Vaduganathan Muthiah , Biering-Sørensen Tor , Qamar Arman , Pandey Ambarish , Olesen Thomas Bastholm , Olsen Michael Hecht , Bhatt Deepak L 
Published: September 2019

Abstract

Aims
The 2018 ESC/ESH guidelines for hypertension recommend differential management of patients who are &lt;65, 65–79, and ≥80 years of age. However, it is unclear whether intensive blood pressure lowering is well-tolerated and modifies risk uniformly across the age spectrum.

Methods and results
SPRINT randomized 9361 high-risk adults without diabetes and age ≥50 years with systolic blood pressure 130–180 mmHg to either intensive or standard antihypertensive treatment. The primary efficacy endpoint was the composite of acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes. The primary safety endpoint was composite serious adverse events. We assessed whether age modified the efficacy and safety of intensive vs. standard blood pressure lowering using Cox proportional-hazards regression and restricted cubic splines. In all, 3805 (41%), 4390 (47%), and 1166 (12%) were &lt;65, 65–79, and ≥80 years. Mean age was similar between the two study groups (intensive group 67.9 ± 9.4 years vs. standard group 67.9 ± 9.5 years; P = 0.94). Median follow-up was 3.3 years. In multivariable models, age was linearly associated with the risk of stroke (P &lt; 0.001) and non-linearly associated with the risk of primary efficacy events, death from cardiovascular causes, death from any cause, heart failure, and serious adverse events (P &lt; 0.001). The safety and efficacy of intensive blood pressure lowering were not modified by age, whether tested continuously or categorically (P &gt; 0.05).

Conclusion
In SPRINT, the benefits and risks of intensive blood pressure lowering did not differ according to the age categories proposed by the ESC/ESH guidelines for hypertension.

Trial Registration
SPRINT (Systolic Blood Pressure Intervention Trial); ClinicalTrials.gov Identifier: NCT01206062, https://clinicaltrials.gov/ct2/show/NCT01206062.
Incubation Period of Shiga Toxin–Producing Escherichia coli
Authors: Awofisayo-Okuyelu Adedoyin , Brainard Julii , Hall Ian , McCarthy Noel 
Published: September 2019

Abstract
Shiga toxin–producing Escherichia coli are pathogenic bacteria found in the gastrointestinal tract of humans. Severe infections could lead to life-threatening complications, especially in young children and the elderly. Understanding the distribution of the incubation period, which is currently inconsistent and ambiguous, can help in controlling the burden of disease. We conducted a systematic review of outbreak investigation reports, extracted individual incubation data and summary estimates, tested for heterogeneity, classified studies into subgroups with limited heterogeneity, and undertook a meta-analysis to identify factors that may contribute to the distribution of the pathogen’s incubation period. Twenty-eight studies were identified for inclusion in the review (1 of which included information on 2 outbreaks), and the resulting I2 value was 77%, indicating high heterogeneity. Studies were classified into 5 subgroups, with the mean incubation period ranging from 3.5 to 8.1 days. The length of the incubation period increased with patient age and decreased by 7.2 hours with every 10% increase in attack rate.
Mortality after use of paclitaxel-based devices in peripheral arteries: a real-world safety analysis
Authors: Freisinger Eva , Koeppe Jeanette , Gerss Joachim , Goerlich Dennis , Malyar Nasser M , Marschall Ursula , Faldum Andreas , Reinecke Holger 
Published: September 2019

Abstract

Aims
Drug-eluting devices (DED) represent a well-established therapy being widely used for endovascular revascularization (EVR) of peripheral vessels. Recent data indicate a two-fold increased long-term mortality in patients treated with paclitaxel-based DED. The subsequent safety concerns affected international regulatory authorities to enunciate several alerts for further application of DED.

Methods and results
In 9.2 million insurants of the German BARMER Health Insurance, data on the application of paclitaxel-based drug-eluting stents (DES) and drug-coated balloons (DCB) were retrieved from their introduction on the market in 2007 until present. All patients with first EVR between 2007 and 2015 were indexed and followed until 31 December 2017. Each subsequently applied DES, DCB, bare-metal stent, and uncoated balloon was included in further analyses. Multivariable Cox regression analysis considered potential non-linear time-dependent hazard ratios (HRs) of DES and DCB over 11 years. We identified 64 771 patients who underwent 107 112 EVR procedures using 23 137 DED. Multivariable Cox regression analysis showed paclitaxel-based DES not to be associated with increased long-term mortality for over 11 years past application (all P &gt; 0.057). DCB was associated with decreased long-term mortality for the first year past application (HR 0.92; P &lt; 0.001), and indifferent correlation in the years thereafter (all P &gt; 0.202).

Conclusion
Our real-world analysis showed no evidence for increased mortality associated with paclitaxel-based DED for over 11 years.