bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL20RB is a Prognostically Significant Gene and a Potential Biomarker in Papillary Renal Cell Carcinoma
Authors: Jiang Tiancheng , Zhang Lei , Mao Weipu , Zhu Yongkun , Wang Ganlin , Wang Guoqing , Chen Shuqiu , Zhang Zhenglin 
Published: October 2024

Abstract

Background
Papillary renal cell carcinoma (pRCC) is the second most common type of renal cancer after clear cell renal cell carcinoma. While diagnostic and therapeutic approaches for pRCC often draw on experiences from clear cell renal cell carcinoma, specific targets for diagnosis and treatment remain elusive. IL20RB, the interleukin 20 receptor subunit β, plays a crucial role in IL20R heterodimerization. Initially associated with a variety of skin diseases, recent studies have implicated IL20RB in various malignancies, yet its role in pRCC remains unclear.
Methods
Prognostic value was determined using the TCGA database and GEPIA, with validation through the analysis of our center’s samples. Subsequent, survival analysis of pRCC patients with high and low IL20RB expression was conducted using R software (version 4.2.1). To further understand the function of IL20RB in pRCC, immune infiltration analysis as well as KEGG/GO enrichment analysis were performed using TRNA sequencing expression profiles from the TCGA database. Protein-protein interactions (PPI) between IL20RB and other proteins in human species were explored using the STRING (String-db.org) database, and drug sensitivity analysis was conducted using the GDSC database.
Results
Our results revealed specific expression of IL20RB in pRCC tumor tissues, with high expression associated with a poorer prognosis and significantly positively correlated with clinical features. Additionlly, IL20RB may function as a cytokine receptor involved in the immune-inflammatory response in the pRCC microenvironment.
Conclusions
IL20RB plays an important role in pRCC and may serve as a potential prognostic oncogene, offering a potential target for future therapeutic interventions.
Relationship of oxidative balance score to gallstone prevalence and gallbladder surgery in American adults: evidence from NHANES 2017-2020
Authors: Wei Shouxin , Yu Sijia , Xu Zhengwen , Qian Chuan , Jia Yindong 
Published: October 2024

Abstract

Gallstones represent a common gastrointestinal disorder, affecting approximately 10-20% of the global population. Oxidative stress plays a pivotal role in the pathogenesis of gallstones; however, there remains a lack of effective clinical indicators to predict their formation. This study addresses this gap by investigating the relationship between oxidative balance score (OBS) and the incidence of gallstones and gallbladder surgery, utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020. Methods: This study investigated the association between OBS and the occurrence of gallstones and gallbladder surgery by analyzing data from NHANES for the period 2017–2020, adjusting for potential confounders such as age, sex, race, and comorbidities. Various statistical analyses were applied, including multivariate logistic regression, subgroup analyses, and smoothed curve-fitting models.Results: The results revealed a significant negative correlation between OBS and the risks of both gallstones and gallbladder surgery, with each one-unit increase in OBS associated with a 2.6% reduction in gallstone risk (OR=0.974, 95% CI: 0.958-0.990) and a 3.3% reduction in the risk of gallbladder surgery (OR=0.967, 95% CI: 0.950-0.983). Subgroup analyses confirmed the consistency of these associations across various demographic and health-related factors. Furthermore, a dose-response relationship was observed between higher OBS and a reduced risk of gallbladder surgery.Conclusions: This study demonstrates that a higher OBS is associated with a lower incidence of gallstones and reduced rates of gallbladder surgery, offering new insights into the link between oxidative stress levels and gallstone formation as well as surgical intervention. The findings underscore the potential of OBS as a valuable tool for identifying at-risk populations and informing personalized prevention strategies for gallstone disease.
CXCL12 regulates breast cancer metastasis and T lymphocyte infiltration
Authors: Liu Xian-Fu , Chen Yan-Song , Tang Jing-Wei , Zhang Hao , Zhang Xiao-Jing 
Published: October 2024

Abstract

Purpose: Breast cancer (BC) is a malignant tumor with the highest incidence rate in women. This work explored the function of CXCL12 in tumor metastasis.
Methods: CXCL12 protein expression levels were assessedby IHC in breast cancer tissues. String revealed thatCXCL12 interacts with CXCL10 protein molecules. The GEPIA2 database revealed that CXCL12 was negatively correlated with CXCL10.CXCL12. The effects of CXCL12 on invasion and migration were detected by scratch and transwell experiments in breast cancer cells. CD4+ T and CD8+ T cells in the inflammatory microenvironment of breast cancer patients were evaluated with the NGDC database and verified by IHC.
Results: CXCL12 knockdown inhibited migration and invasion and enhanced the expression and secretion of CXCL10 in BC. CXCL10 isresponsible for the recruitment of CD4+ and CD8+ T lymphocytes into tumors and enhances antitumoreffects. The single-cell data showed that the patients in the CXCL10+CD4+/CD8+ T-cell group and the CXCL12-CD4+/CD8+ T-cell group had better prognoses.
Conclusions:CXCL12 promoted BC migration and invasion. On the otherhand, CXCL12 inhibited the expression and secretion of CXCL10, further inhibiting T lymphocyteinfiltration and promoting breast cancer metastasis in the TME.
Influence of the filling technique on endodontic retreatment in curved mesial canals of mandibular molars – An in vitro study
Authors: Copelli Felipe Andretta , Oda Lisa Yurie , Leal Renata Maira Souza , Rodrigues Clarissa Teles , Duarte Marco Antonio Hungaro , Cavenago Bruno Cavalini 
Published: October 2024

Abstract

Objectives: To evaluate the influence of the filling technique associated with a bioceramic sealer on the remaining filling material and the impact on the remaining dentin after the filling removal in the retreatment of curved mesial canals of mandibular molars.
Materials and Methods:Eighteen curved mesial roots of mandibular molars with Vertucci type IV canals were prepared up to instrument 35/.05. Two groups were established according to the filling technique: single-cone (n=18) and continuous wave of condensation (n=18). Bio-C Sealer was used for both techniques. The filling was removed using the Reciproc Blue R25 instrument, and the repreparation was carried out using the Reciproc Blue R40 instrument. The samples were scanned by micro-CT before and after the filling removal. For statistical analysis, the data normality was checked, and parametric tests were used for normal distribution and non-parametric tests for non-normal distribution.
Results: The remaining filling material was observed in both groups during retreatment, with no differences. Analyses of transportation and centering ability also indicated similarities between the two groups.
Conclusions: Endodontic retreatment in curved mesial canals of mandibular molars filled with single-cone or continuous wave of condensation techniques and filled with bioceramic sealer was similar. The use of reciprocating instruments for filling removal and repreparation was efficient in curved mesial canals of mandibular molars, with no complications.
Clinical relevance: The filling technique did not influence the non-surgical endodontic retreatment in curved mesial canals. Regardless of the technique, it was not possible to remove all the filling material from the root canals.
Numerical simulation of soliton solutions of nonlinear Fitzhugh-Nagumo equation by using LOOCV with exponential B-spline with Significant Applications in Neurosciences
Authors: RANI RICHA , ARORA GEETA 
Published: October 2024

Abstract

This study focuses on solving the one-dimensional nonlinear Fitzhugh-Nagumo (FHN) equation using a novel technique called the “Exponential modified cubic B-spline differential quadrature method” combined with “leave-one-out cross-validation”. The inclusion of leave-one-out cross-validation (LOOCV) is essential for finding the optimal value of the parameter \(\:\lambda\:\), which is a key component in the exponential modified cubic B-spline basis functions, thereby enhancing the accuracy and robustness of the results. By incorporating this unique combination of LOOCV and the exponential modified cubic B-spline differential quadrature method, the research introduces a new computational approach that could be of considerable interest to scholars in the field. This method has been applied to four different examples of the Fitzhugh-Nagumo equation, with outcomes detailed in tables and figures. This paper presents the methodology and results of a study on the equation, emphasizing its significance and applications in neuroscience. The Fitzhugh-Nagumo model is highlighted as a versatile tool across various scientific, engineering, and mathematical fields, with a particular focus on its role in understanding the complex dynamics of neural systems and its potential impact on future research and real-world problems.
Application and research prospects of straw in clean production
Authors: Ye Haodong , Wen Jun , Ouyang Shasha 
Published: October 2024

Abstract

The abundance of straw resources provides a fertile ground for research on the current state of their clean production and circular application. Leveraging the Web of Science (WOS) database as the primary data source and utilizing the CiteSpace literature analysis tool, this study conducts a visual analysis of research literature related to rice straw. It explores parameters such as publication volume, authors, research institutions, countries, keywords, and more, providing a knowledge map for better understanding. The research findings offer an objective and scientific overview of the quantity and annual trends in literature pertaining to the application of straw materials in clean production. Moreover, the study identifies high-frequency keywords, prolific authors, publishing institutions, and research frontiers and directions, thereby establishing a research framework based on straw for clean production application. This study also serves as valuable reference material for scholars in related fields, providing insights for future diversified research endeavors.
Comparison of Hetrombopag and Eltrombopag added to first-line immunosuppressive therapy in severe aplastic anemia
Authors: Zhang Baohang , Yang Wenrui , Kang Rui , Shi Yimeng , Hu Xiangrong , Zhang Li , Jing Liping , Yuan Weiping , Shi Jun , Zhang Fengkui , Zhao Xin 
Published: October 2024

Abstract

The addition of thrombopoietin receptor agonists (TPO-RAs) to immunosuppressive therapy (IST) improves the hematologic response rate and quality in patients with severe aplastic anemia (SAA). However, no studies have yet reported on whether there are differences in the efficacy of TPO-RAs. Here we analyzed the clinical data of SAA patients who received hetrombopag (HPAG) or eltrombopag (EPAG) as part of first-line standard IST between March 2020 and June 2022 to compare the efficacy of HPAG and EPAG in SAA patients. Sixty-seven patients were enrolled in the HPAG group and 42 patients in the EPAG group, with a similar proportion of very severe aplastic anemia (VSAA) patients between the two groups (26.9% vs 33.3%, P = 0.613). The overall hematologic response (OR) rates of the HPAG group at 3 and 6 months after IST were 50.7% and 65.6%, respectively, close to that of the EPAG group (50%, P = 0.973; 73.8%, P = 0.494). The rates of complete response (CR) at 3 and 6 months were 13.4% and 31.3% in the HPAG group, respectively, which were like those in the EPAG group (11.9% and 28.6%), with no statistical difference (P = 1.00 and 0.59). The median time to first response (3.0 months vs 3.2 months, P = 0.79) was similar in HPAG and EPAG. We further analyzed data of VSAA patients. The OR rate, CR rate and the time to obtain first response in VSAAs were comparable between the two groups. The median follow-up time of HPAG group was 22.38 (3-33.27) months, and that of EPAG group was 33.9 (9.4–49.2) months. The overall survival (OS) rates were 91.0% and 92.8% in HPAG group and EPAG group (P = 0.53), respectively. Monosomy 7 was detected in 1 patient in EPAG group and her disease transformed to acute myelocytic leukemia (AML) at 25 months after ATG treatment. One patient in HPAG had trisomy 8 at 9 months of ATG treatment, and bone marrow examination showed no disease progression. Conclusion: The addition of HPAG to standard IST in SAA patients showed similar response rates and response quality to that of EPAG. HPAG could be an alternative of EPAG for the first-line treatment of SAA patients.
Using Dynamic Token Embedding Compression to Optimize Inference Process in Large Language Models
Authors: Gavrilo Diana , Johansson Christopher , Petrovich Thomas , Martins Gabriel , Edwards Samuel 
Published: October 2024

Abstract

Large-scale deep learning architectures, while transformative for language understanding and generation, impose substantial computational and memory demands during inference, often limiting their practical deployment in constrained environments. Introducing a novel methodology, Dynamic Token Embedding Compression (DTEC), this work addresses these challenges through a selective token embedding mechanism that dynamically adjusts embedding dimensionality based on contextual relevance during inference. DTEC optimizes memory usage and inference time by applying high compression to low-relevance tokens while preserving dimensionality for those deemed critical to context, resulting in significant improvements in resource efficiency. Experimental results demonstrate that DTEC reduces inference time by 25.6% and memory consumption by 30.2% on average across various text lengths without compromising model accuracy or output quality. Moreover, DTEC effectively lowers hallucination rates, enhancing model fidelity and strengthening its application across tasks requiring precision and reliability. With its adaptive token prioritization, DTEC emerges as an efficient framework for resource-limited environments and a promising approach for real-time, scalable LLM deployment.
Inequality in human development amplifies climate-related disaster risk
Authors: Teber Khalil , Sippel Sebastian , Krause Melanie , Zscheischler Jakob , Mahecha Miguel 
Published: October 2024

Abstract

The severity of climate disaster impacts is shaped not only by the intensity of the
events themselves but also by the exposure, vulnerability, and adaptive capac-
ity of affected communities. The lack of globally comparable data integrating
local societal and climatic conditions poses significant challenges to understand-
ing which factors transform hazardous events into disasters. Existing research
often neglects both hazard intensity and within-country inequality when analyz-
ing the relationship between climate hazard events and their outcomes.
Here, analyzing over 7,000 climate-related disasters from 1990 to 2020, we show
that human development drives major shifts in global exposure and impact pat-
terns, with societal vulnerability outweighing hazard intensity in driving impacts.
Regions with low subnational Human Development Index (sHDI) scores expe-
rience disproportionately higher human losses and economic damage, despite
reduced hazard exposure over the past three decades. For instance, individuals
in these regions are 8.2 times (95% CI: 2.16–23.06) more likely to be killed by
storms compared to those in very high sHDI regions. Our findings also indicate
that within-country inequality exacerbates disaster risk in low- and medium-sHDI
regions. These results underscore the critical role of human development in miti-
gating disaster risks and highlight the link between socioeconomic conditions and
disaster vulnerability.
Treatment with Ascorbyl Glucoside Arginine Complex ameliorates solar lentigos
Authors: Takada Mariko , Numano Kayoko , Nakano Masahiko , Yamamoto Akio , Imokawa Genji 
Published: October 2024

Abstract

Little is known about anti-pigmenting effects of whitening agents on solar lentigo (SLs). To characterize the anti-pigmenting effects of newly designed ascorbyl glucoside arginine complex (AGAC) on SLs, lotions with or without 28% AGAC were applied twice daily for 24 weeks in a double-blind half-face study of 27 Japanese females with SLs. Pigmentation scores were evaluated using a photo-scale and skin colors were assessed using a color difference meter and a Mexameter. Treatment with the test lotion elicited a significant decrease in pigmentation scores at 24 weeks com-pared to week 0, with a significant decrease in pigmentation scores at 24 weeks compared to the placebo lotion-treated SLs. In the test lotion-treated SLs, the lightness (L) values and melanin index (MI) reflecting pigmentation level significantly (p<0.0001) increased and decreased, respectively, at 12 and 24 weeks of treatment compared to week 0. Comparisons of increased L values or decreased MI values between the test and placebo lotion-treated SLs demonstrated that the test lotion-treated SLs had significantly higher increased L or decreased MI values than the placebo lotion-treated SLs both at 12 and 24 weeks of treatment. The sum of our results strongly indicates that AGAC is distinctly effective in ameliorating the hyperpigmentation levels of SLs at a visibly recognizable level by the subjects without any hypo-pigmenting effects or skin irritation.
Role and mechanism of Pim-2 kinase inhibitors-induced immunogenic cell death in multiple myeloma
Authors: Liu Zhaoyun , Shen Hongli , Che Mengting , Zhao Xianghong , Wang Hao , Yang Chun , Fu Rong 
Published: October 2024

Abstract

Background Immune dysfunction is an important part of pathogenesis in multiple myeloma, and restoring anti-myeloma immunity has become a key research direction.
Methods This article demonstrates through in vivo and in vitro experiments whether and how Pim-2 kinase inhibitors induce immunogenic cell death in multiple myeloma.
Results In this study, Pim-2 kinase inhibitors up-regulate IRE1 phosphorylation, promote XBP1 and CHOP transcription, thereby mediating endoplasmic reticulum stress in MM cells. Endoplasmic reticulum stress(ER-stress) and increased reactive oxygen species(ROS) levels can promote the expression of damage related molecular patterns and promote immunogenic cell death in MM cells. In addition, Pim-2 kinase inhibitors-treated MM cell lines can up-regulate the expression of activation molecules on the surface of Dendritic cells(DCs) from MM patients, promote T lymphocyte differentiation from Naïve T cells to effector memory T cells, and promote the expression of T lymphocyte functional molecules. In vivo, it is shown that Pim-2 kinase inhibitors can simulate human DCs maturation and activate functional T lymphocytes.
Conclusions As a consequence, these data improve our knowledge about how Pim-2 kinase inhibitors regulates anti-myeloma immunity and provide justification for applying Pim-2 kinase inhibitors in multiple myeloma(MM) treatment.
ЛЕС БРОСЕЛИАНД В СОВРЕМЕННОЙ ФРАНЦУЗСКОЙ БРЕТАНИ КАК ТЕРРИТОРИЯ ВООБРАЖАЕМОГО ПРОСТРАНСТВА
Authors: М.К. ЛЮБАРТ 
Published: October 2024

Лес Броселианд — мифический лес средневековых легенд артурианского цикла, был в течение XIX–XX вв. идентифицирован с частью реального леса Пемпон (Бретань, Франция). Он стал территорией «материализации» чудесных персонажей, героев, легендарных событий, что выражается в нахождении в нем «тех самых мест», где происходило то или иное легендарное событие, деятельности туристических и культурных организаций, иллюстрирующих (иногда с помощью аниматоров, артистов, художников) мифические события. Лес, пользующийся большой популярностью и из-за природной ценности, стал также неким пространством, где воплощаются мифологические исторические представления, фантазии как профессиональных творческих людей, обычных посетителей, а также приверженцев неоязыческих культов, прежде всего неодруидизма.
The Broceliand forest is a mythical forestof medieval Arthurian legends,which was identified duringthe XIX–XX centuries witha part of the real forestof Paempon (Brittany, France). It has become the territoryof the «materialization» of wonderful characters, heroes, legendary events, which is expressed in finding in it«the very places» where this or that legendary event took place, the activitiesof tourist and cultural organizations illustrating (sometimes withthe help of animators, artists, artists) mythical events.The forest, which is very popular because ofits natural value, has also become a kind of space where mythological historical ideas, fantasies of professional creative people, ordinary visitors, as well as adherents of neo-pagan cults, primarily neo-Druidism, are embodied.
Decorative properties of cultivars of Liquidambar styraciflua L.
Authors: Svitylko I. M. 
Published: October 2024

Purpose. To determine the structure, and color of the leaf, the bark of the branches, the habit of the crown, the linear characteristics of the plants, the features of flowering and fruiting of Liquidambar styraciflua L. and its cultivars. Provide recommendations for their use in landscaping. Methods.
The subjects of the research were cultivars of L. styraciflua, which were found in arboretums, parks, squares, garden centers, nurseries and in green areas throughout Ukraine. The plants were evaluated according to a complex scale of ornamental value of woody plants, which includes four levels of ornamental value of trees and shrubs: very high, high, medium and low. The methods of observation, analysis, comparison, data summarization, photo­fixation and descriptive­taxation method were used. Results. A comprehensive assessment of the decorative effect of L. styraciflua cultivars (‘Worplesdon’, ‘Gum Ball’, ‘Rotundiloba’, ‘Albomarginata Manon’, ‘Oakville Highlight’, ‘Slender Silhouette’, ‘Fastigiatа’, ‘Pasquali’, ‘Stared’, ‘Thea’, ‘Aurea’, ‘Golden Treasure’, ‘Variegata’, ‘Golden Sun’, ‘Stella’, ‘Stella Rossa’) against species plants was carried out. Based on the results of the research, a table was compiled to help landscape architects, nursery and garden center workers, botanists and ecologists, students and staff of forestry and botanical institutions in the selection of plants. Recommendations are given for the use of L. styraciflua cultivars in landscaping. Conclusions. According to the degree of ornamentality, the vast majo­rity of L. styraciflua cultivars (13) belong to group I (very high, 65–90 points). They are recommended for use in urban and domestic landscaping and for the creation of various landscape objects. Group II (high ornamental value, 51–64 points) contains two cultivars, and group III (moderate ornamental value, 41–50 points) contains only one cultivar.