bluuebunny/crossref_metadata_2025_split huggingface dataset:
G-Protein-Coupled Receptor-Membrane Interactions Depend on the Receptor Activation state
Authors: Bhattarai Apurba , Wang Jinan , Miao Yinglong 
Published: August 2019

AbstractG-protein-coupled receptors (GPCRs) are the largest family of human membrane proteins and serve as primary targets of ∼1/3 of currently marketed drugs. In particular, adenosine A1 receptor (A1AR) is an important therapeutic target for treating cardiac ischemia-reperfusion injuries, neuropathic pain and renal diseases. As a prototypical GPCR, the A1AR is located within a phospholipid membrane bilayer and transmits cellular signals by changing between different conformational states. It is important to elucidate the lipid-protein interactions in order to understand the functional mechanism of GPCRs. Here, all-atom simulations using a robust Gaussian accelerated molecular dynamics (GaMD) method were performed on both the inactive (antagonist bound) and active (agonist and G protein bound) A1AR, which was embedded in a 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC) lipid bilayer. In the GaMD simulations, the membrane lipids played a key role in stabilizing different conformational states of the A1AR. Our simulations further identified important regions of the receptor that interacted distinctly with the lipids in highly correlated manner. Activation of the A1AR led to differential dynamics in the upper and lower leaflets of the lipid bilayer. In summary, GaMD enhanced simulations have revealed strongly coupled dynamics of the GPCR and lipids that depend on the receptor activation state.
Conserved abilities of individual recognition and genetically modulated social responses in young chicks (Gallus gallus)
Authors: Versace Elisabetta , Ragusa Morgana , Pallante Virginia 
Published: August 2019

AbstractThe ability to recognise familiar individuals and the motivation to stay in contact with conspecifics are important to establish social relationships from the beginning of life. To understand the genetic basis of early social behaviour, we studied the different responses to familiar/unfamiliar individuals and social reinstatement in 4-day-old domestic chicks (Gallus gallus) in three genetically isolated breeds: Padovana, Polverara and Robusta. All breeds showed a similar ability to discriminate between familiar and unfamiliar individuals, staying closer to familiar individuals. Social reinstatement motivation measured as the average distance between subjects, latency to the first step and exploration of the arena (a proxy for the lack of fear), differed between breeds. More socially motivated chicks that stayed in closer proximity, were also less fearful and explored the environment more extensively. These results suggest that modulation of social behaviour shows larger genetic variability than the ability to recognise social partners, which appears to be an adaptive ability widespread at the species level even for very young animals.
Early career values and individual factors of objective career success
Authors: Giraud Laurent , Bernard Alain , Trinchera Laura 
Published: August 2019

PurposeThe purpose of this paper is to investigate the early career values and individual factors of objective career success among graduates from a top-tier French business school.Design/methodology/approachThe authors conducted a quantitative analysis of 629 graduates classified in three job markets according to income: the traditional business market, the alternative market and the high-potential business market. The graduation dates span a period of 12 years before the 2008 Recession.FindingsThe findings suggest that membership of each job market is associated with distinct early career values (when choosing/leaving the first job). Moreover, the authors confirm that the presence of a mentor, international experience, job-hopping and gender, all affect objective career success.Practical implicationsThe paper discusses implications for business career development and higher business education.Originality/valueThe originality of this study lies in the identification of the individual factors of objective career success among French business graduates and the links between objective career success and early career values.
Technology business incubation for start-up generation
Authors: Mungila Hillemane Bala Subrahmanya , Satyanarayana Krishna , Chandrashekar Deepak 
Published: August 2019

Purpose
Technology business incubators (TBIs) form an indispensable part of an entrepreneurial ecosystem for the promotion of tech start-ups across the global economy. However, they have evolved in varied forms over a period of time, in terms of typologies, sponsors and stakeholders, goals and objectives, functions and services offered, process of incubation support provided through hard and soft infrastructure, outcomes and achievements and even in terms of theoretical bases. The purpose of this paper, therefore, is to review the extant literature on TBIs to arrive at a framework that explains how TBIs contribute to start-up generation.

Design/methodology/approach
This paper reviews extant empirical literature for a systematic evaluation to throw light on the various dimensions of TBIs: typology, goals and objectives, functions and services, process and provision of incubation support, outcomes and achievements. Further, after critically reviewing some of the theoretical propositions, it develops a conceptual framework combining pre-incubation, incubation and post-incubation processes of TBIs.

Findings
Based on literature understanding and some of the key theoretical constructs, a conceptual framework is developed comprising pre-incubation, incubation and post-incubation stages of start-up formation and graduation. The paper also identifies some prospective areas for future research.

Research limitations/implications
Any empirical research on technology business incubation must focus on pre-incubation and post-incubation processes as much as on the incubation process, to derive meaningful implications and enhance the productivity of TBIs.

Originality/value
The conceptual framework derived out of the systematic literature review will enable further research and exploration of micro-aspects of pre-incubation, incubation and post-incubation phases across multiple dimensions.
Moving beyond the first response phenomenon
Authors: Malm Camilla , Andersson Stefan , Jönson Håkan , Magnusson Lennart , Hanson Elizabeth 
Published: August 2019

Purpose
In Sweden, the care of older people and people with disabilities is increasingly carried out by informal carers, often family members, who are unpaid and outside a professional or formal framework. While there is an increasing awareness of the role of carers within service systems and their own needs for support, their involvement in research is underexplored. The purpose of this paper is to explore carers’ views and experiences of involvement in research and development (R&D) work.

Design/methodology/approach
A qualitative study was conducted, consisting of 12 individual interviews with carers from different local Swedish carer organizations.

Findings
Core findings included carers’ discussions of the perceived challenges and benefits of their involvement in research, both generally and more specifically, in the context of their involvement in the development of a national carer strategy.

Research limitations/implications
Limitations included the relative lack of male carer participants and the convenience sample.

Practical implications
Authentic carer involvement in research demands a high level of engagement from researchers during the entire research process. The provided CRAC framework, with reference to the themes community, reciprocity, advocacy and circumstantiality, may help researchers to understand and interpret carer involvement in research and provide the prerequisites for their involvement.

Originality/value
There is a dearth of studies that systematically examine carer involvement in research. This paper attempts to redress this gap by providing a nuanced analysis of carer involvement in R&D work from the perspective of carers themselves.
Does abusive supervision always promote employees to hide knowledge? From both reactance and COR perspectives
Authors: Feng Jiaojiao , Wang Changyu 
Published: August 2019

PurposeKnowledge hiding as an important topic in knowledge management field might be triggered by abusive supervision, but few studies discussed how to alleviate the effect of abusive supervision on knowledge hiding. Drawing on both reactance theory and conservation of resources (COR) theory, this study aims to build a moderated mediation framework to examine effects of abusive supervision on knowledge hiding via job insecurity and under moderation of motivational climate (including mastery climate and performance climate).Design/methodology/approachThe paper uses a two-wave survey study among 155 knowledge workers from educational and manufacturing industries.FindingsResults show that abusive supervision is not significantly related to knowledge hiding directly but indirectly via job insecurity. Abusive supervision’s interaction with mastery climate is negatively related to knowledge hiding, but its interaction with performance climate is positively related to knowledge hiding. The indirect relation of abusive supervision to knowledge hiding via job insecurity is significantly moderated by mastery climate but not by performance climate.Research limitations/implicationsDespite contributions, this study also has some limitations. Variables rated from the same source (i.e. employees) may have common method bias although the two-wave design does help alleviate this concern.Practical implicationsThe paper highlights important reasons why people hide knowledge at work (because of abusive supervision and job insecurity) and identifies a boundary condition (mastery climate) which will reduce abusive supervision’s influence on knowledge hiding.Originality/valueThis paper contributes to knowledge hiding literature which is an important part of knowledge management from the perspective of abusive supervision based on both reactance theory and COR theory.
A 3‐hydroxy‐3‐methylglutaryl‐CoA synthase‐based probe for the discovery of the acyltransferase‐less type I polyketide synthases
Authors: Liang Haoyu , Jiang Lin , Jiang Qiyun , Shi Jie , Xiang Jingxi , Yan Xiaohui , Zhu Xiangcheng , Zhao Lixing , Shen Ben , Duan Yanwen , Huang Yong 
Published: August 2019

SummaryAcyltransferase (AT)‐less type I polyketide synthases (PKSs) produce complex natural products due to the presence of many unique tailoring enzymes. The 3‐hydroxy‐3‐methylglutaryl coenzyme A synthases (HCSs) are responsible for β‐alkylation of the growing polyketide intermediates in AT‐less type I PKSs. In this study, we discovered a large group of HCSs, closely associated with the characterized and orphan AT‐less type I PKSs through in silico genome mining, sequence and genome neighbourhood network analyses. Using HCS‐based probes, the survey of 1207 in‐house strains and 18 soil samples from different geographic locations revealed the vast diversity of HCS‐containing AT‐less type I PKSs. The presence of HCSs in many AT‐less type I PKSs suggests their co‐evolutionary relationship. This study provides a new probe to study the abundance and diversity of AT‐less type I PKSs in the environment and microbial strain collections. Our study should inspire future efforts to discover new polyketide natural products from AT‐less type I PKSs.
Indigenous sovereignties: relational ontologies and environmental management
Authors: Muller Samantha , Hemming Steve , Rigney Daryle 
Published: August 2019

AbstractIndigenous nations have always and continue to assert their sovereignties to resist colonialism. This paper makes explicit the ways in which environmental management has been and continues to act as a tool of colonialism, particularly by privileging Western science, institutions, and administrative procedures. We argue that to decolonise environmental management, it is crucial to understand and challenge the power relations that underlie it—asking who makes decisions and on what worldview those decisions are based. Indigenous ways of being deeply challenge the foundations of environmental management and the colonising power structures that underlie it, and invite further thought about posthuman and relational ontologies. We provide a range of case studies that showcase the role of Indigenous nations in redefining and reimagining environmental management based on Indigenous sovereignties, knowledges, and ways of being. The case studies emphasise the crucial connection between Indigenous decision‐making authority and self‐governance for the enhanced protection and health of the environment. We argue that Indigenous agency, grounded in Indigenous governance and sovereignties, is driving innovation and decolonising environmental management by making space for new ways of thinking and being “in place”.
Citizenship as Sovereign Wealth: Re‐thinking Investor Immigration
Authors: Gamlen Alan , Kutarna Chris , Monk Ashby 
Published: August 2019

AbstractSelling membership into society has taken on new life with the recent proliferation globally of Immigrant Investor Programs (IIPs). IIPs involve the sale of national membership privileges to wealthy foreigners, justified by their purported ability to stimulate economic development and attract engaged investor‐migrants. This paper surveys IIP objectives, activities and performance. We argue that IIP success may depend upon the coming‐together of expertise from two domains – migration policy and investment management, and that the latter may offer a means of legitimizing the former. Drawing some insights from the emerging community of Sovereign Development Funds (SDFs), we propose a set of principles that could guide the emergence of a new type of SDF: Immigrant Investment Funds (IIFs).
Duration of critically low oxygen delivery is associated with acute kidney injury after cardiac surgery
Authors: Rasmussen Sebastian R. , Kandler Kristian , Nielsen Rikke V. , Cornelius Jakobsen Peter , Knudsen Nikoline N. , Ranucci Marco , Christian Nilsson Jens , Ravn Hanne B. 
Published: August 2019

BackgroundAcute kidney injury is a serious complication following cardiac surgery associated with mortality. Restricted oxygen delivery is a potential risk factor for acute kidney injury. The aim of this study was to investigate the impact of the duration of low oxygen delivery (<272 mL min−1 m−2), during cardiopulmonary bypass on kidney function.MethodsPatients undergoing coronary artery bypass graft surgery ± valve repair were included n = 1968. Oxygen delivery was monitored during cardiopulmonary bypass. Data were explored using multiple regression analyses regarding association between low oxygen delivery and renal replacement therapy (RRT), acute kidney injury (AKI) and post‐operative peak serum creatinine (PPSC).ResultsPost‐operative peak serum creatinine, incidence of acute kidney injury, and need for dialysis increased in a dose‐dependent manner in relation to duration of a mean oxygen delivery <272 mL min−1 m−2. Using multiple regression analyses, only exposure for at least 30 minutes was independently associated with increased PPSC and AKI. In contrast, both short (1‐5 min, OR: 2.58 [1.20, 5.54]; P = .015) and at least 30‐minute (OR: 2.85 [1.27‐6.41]; P = .011) exposure to low DO2 were both independently associated with the need for RRT.ConclusionA low oxygen delivery during cardiopulmonary bypass was in a dose‐dependent manner associated with an increased risk of renal injury.
Checklists in pre‐hospital advanced airway management
Authors: Klingberg Cecilia , Kornhall Daniel , Gryth Dan , Krüger Andreas J. , Lossius Hans Morten , Gellerfors Mikael 
Published: August 2019

BackgroundIn pre‐hospital care, pre‐intubation checklists (PICL) are widely implemented as a safety measure and guidelines support their use. However, the true value of PICL among experienced airway providers is unknown. This study aims to explore possible benefits and disadvantages of PICL in the pre‐hospital setting.MethodsWe performed a subgroup analysis of a prospective, observational, multicentre study on pre‐hospital advanced airway management in the Nordic countries between May 2015 and November 2016. The original trial was designed to investigate the success rates of pre‐hospital tracheal intubations and the incidence of complications. Our study limited inclusion to drug assisted intubations performed by anaesthesiologists. Intubation success rates and complication rates were plotted against checklist use.ResultsWe analyzed 588 pre‐hospital intubations for medical and traumatic emergencies. Overall, checklists were used in 60.5% of instances. Applying checklists was associated with increased success at first and second intubation attempts. There was no significant difference in the overall success rates (99.4% and 99.1%). Oesophageal misplacement was more common in the No‐PICL group (2.2% vs 0.3%) but otherwise the incidence of airway related complications did not differ between the groups. Scene time was significantly shorter in the No‐PICL group (23.6 vs 27.5 minutes).ConclusionIn this retrospective study, checklist use correlated with fewer attempts at intubation when securing the airway. Despite this, we found no association between checklist use and the overall TI success rate or the incidence of serious adverse events. Scene times were shorter without PICL.
Patient‐controlled sedation with propofol for endoscopic procedures—A cost analysis
Authors: Grossmann Benjamin , Nilsson Andreas , Sjöberg Folke , Bernfort Lars , Nilsson Lena 
Published: August 2019

BackgroundPatient‐controlled sedation (PCS) with propofol accompanied by a bedside nurse anaesthetist is an alternative sedation method for endoscopic procedures compared with midazolam administered by a nurse or endoscopist. Increasing costs in health care demands an economic perspective when introducing alternative methods. We applied a hospital perspective on a cost analysis comparing different methods of sedation and the resource use that were expected to affect cost differences related to the sedation.MethodsBased on two randomised previous studies, the direct costs were determined for different sedation methods during two advanced endoscopic procedures: endoscopic retrograde cholangiopancreatography (ERCP) and flexible bronchoscopy including endobronchial ultrasound. ERCP comparisons were made between midazolam sedation by the endoscopic team, PCS with a bedside nurse anaesthetist and propofol sedation administered by a nurse anaesthetist. Bronchoscopy comparisons were made between midazolam sedation by the endoscopic team and PCS with a bedside nurse anaesthetist, categorised by premedication morphine‐scopolamine or glycopyrronium.ResultsPropofol PCS with a bedside nurse anaesthetist resulted in lower costs per patient for sedation for both ERCP (233 USD) and bronchoscopy (premedication morphine‐scopolamine 267 USD, premedication glycopyrronium 269 USD) compared with midazolam (ERCP 425 USD, bronchoscopy 337 USD). Aborted procedures that needed to be repeated and prolonged hospital stays significantly increased the cost for the midazolam groups.ConclusionPropofol PCS with a bedside nurse anaesthetist reduces the direct sedation costs for ERCP and bronchoscopy procedures compared with midazolam sedation.
Inequity in physiotherapeutic interventions for children with Cerebral Palsy in Sweden—A national registry study
Authors: Degerstedt Frida , Enberg Birgit , Keisu Britt‐Inger , Björklund Martin 
Published: August 2019

AbstractAimThe aim of this study was to investigate the distribution of physiotherapeutic interventions for children with Cerebral Palsy in Sweden from an equity perspective, considering sex, country of birth and geographical region.MethodThis national cross‐sectional registry study includes children with Cerebral Palsy aged 0‐18 years who participated in 2015 in the Swedish national quality registry, the Cerebral Palsy follow‐up programme, CPUP. Comparisons and associations between physiotherapeutic interventions and sex, country of birth and geographical regions were conducted using chi‐square and logistic regression analysis, controlling for cognitive level, level of motor function, age group and dominating symptom.ResultsOf the 2855 participants, 2201 (79%) had received physiotherapy. Children born in Sweden had 1.60 times higher odds (95% CI 1.10‐2.33) of receiving physiotherapy compared with children born in foreign countries. Distribution of physiotherapeutic interventions differed significantly between geographical regions. No associations between sex and physiotherapeutic interventions were observed.ConclusionThe results of this study indicate inequity in care in Sweden towards children with Cerebral Palsy born in other counties. Further, physiotherapeutic interventions were not equally distributed in different geographical regions of Sweden. Knowledge of inequity is crucial in order to address the problem.
Influences of different Fe sources on Fe bioavailability and homeostasis in SD rats
Authors: Lin Yu , Shu Xugang , Fu Zhihuan , Hu Hongchao , Wang Wen-Xiong , Gong Sheng 
Published: August 2019

AbstractThe purpose of this study was to determine whether the enteric coating process affects growth performance, Fe bioavailability, and gene expression levels that maintain iron balance in the body. The test was divided into the control group, ferrous sulfate group, ferrous fumarate group, ferrous glycine chelate(1:1) (Fe‐Gly(1:1)) group, ferrous glycine chelate(2:1) (Fe‐Gly(2:1)) group, enteric‐coated Fe‐Gly(1:1) group, and enteric‐coated Fe‐Gly(2:1) group. The results showed that the growth performance of the rats in each iron supplement group was no significant difference among them. The results of serum biochemical indicators showed that the antioxidant capacity of the rats in the iron supplement group after enteric coating increased. The iron supplementation effect of Fe‐Gly(1:1) and Fe‐Gly(2:1) was better than that of ferrous sulfate, and the effect of Fe‐Gly(1:1) after enteric coating was enhanced. The expression levels of IRP1 and IRP2 in the genes of enteric‐coated Fe‐Gly(1:1) and enteric‐coated Fe‐Gly(2:1) were significantly higher than those of ferrous sulfate. The expression levels of IRP1 and IRP2 in the protein of enteric‐coated Fe‐Gly(1:1) group were significantly higher than those in the Fe‐Gly(1:1) group. The above results show that Fe‐Gly can improve the bioavailability and antioxidant capacity of iron and reduce the iron output of feces after enteric coating.