bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Leo-I group: new dwarf galaxy and ultra diffuse galaxy candidates
Authors: Müller Oliver , Jerjen Helmut , Binggeli Bruno 
Published: April 2018

Context. The study of dwarf galaxies and their environments provides crucial test beds for predictions of cosmological models and insights into the structure formation on small cosmological scales. In recent years, many problems on the scale of groups of galaxies has challenged the current standard model of cosmology.
Aims. Our aim is to increase the sample of known galaxies in the Leo-I group, which contains the M 96 subgroup and the Leo Triplet. This galaxy aggregate is located at the edge of the Local Volume at a mean distance of 10.7 Mpc.
Methods. We employed image enhancing techniques to search for low surface brightness objects in publicly available gr images taken by the Sloan Digital Sky Survey within 500 square degrees around the Leo-I group. Once detected, we performed surface photometry and compared their structural parameters to other known dwarf galaxies in the nearby universe.
Results. We found 36 new dwarf galaxy candidates within the search area. Their morphology and structural parameters resemble known dwarfs in other groups. Among the candidates five or six galaxies are considered as ultra diffuse galaxy candidates. If confirmed, they would be some of the closest examples of this galaxy type. We assessed the luminosity function of the Leo-I group and find it to be considerably rich in dwarf galaxies, with twice the number of galaxies as the Local Group at a limiting magnitude of MV = −10 and a steeper faint-end slope.
Spezifisch belastungsbezogene psychische Störungen im neuen ICD-11: Ein Überblick
Authors: Augsburger Mareike , Maercker Andreas 
Published: April 2018

ZusammenfassungMit der Veröffentlichung des neuen ICD-11 gehen wichtige Änderungen in der Klassifizierung belastungsbezogener psychischer Störungen einher. Unter dem
Zielkonzept „klinische Nützlichkeit“ entwickelt, können in der neuen Version erstmals unterschiedliche Störungsbilder kodiert werden, die als Reaktion auf das
Erleben verschiedener Arten von Stressoren entstehen. Die Störungsbilder reichen von der Reaktion auf psychosoziale Belastungen (Anpassungsstörung), über eine
behandlungsbedürftige Trauerreaktion (Anhaltende Trauerstörung), bis hin zu den Folgen des Überlebens potenzieller traumatischer Ereignisse mit dem klassischen
Bild (Posttraumatische Belastungsstörung) bzw. mit einem komplexeren klinischen Bild (Komplexe Posttraumatische Belastungsstörung). Dieser Artikel gibt einen
Überblick über die wesentlichen Veränderungen in den Kriterien im Wechsel von ICD-10 auf ICD-11. Außerdem werden, wenn vorhanden, aktuelle Prävalenzraten
berichtet und Empfehlungen für diagnostische Verfahren gegeben. Ebenso erfolgt eine Betrachtung der anhaltenden wissenschaftlichen Diskussionen im Hinblick auf
die neuen Diagnosen.
Cushing’s Syndrome: A Historic Review of the Treatment Strategies and Corresponding Outcomes in a Single Tertiary Center over the Past Half-Century
Authors: Nankova Anelia , Yaneva Maria , Elenkova Atanaska , Tcharaktchiev Dimitar , Marinov Marin , Hadzhiyanev Asen , Sechanov Tanyo , Gantchev Georgi , Todorov Georgi , Kirilov Georgi , Kalinov Krasimir , Andreeva Maria , Zacharieva Sabina 
Published: April 2018

AbstractCushing’s syndrome (CS) is associated with serious comorbidities and an increased mortality rate that could be reduced only if strict biochemical control is achieved. The aim of this study was to show the 50-year experience of a single tertiary center in the management of CS patients – the different treatment modalities used over the years and the corresponding outcomes. It was a retrospective study of a large cohort of patients from the Bulgarian CS database: 613 patients (374 with ACTH-dependent and 239 with ACTH-independent CS). Pituitary surgery was applied to 242 patients with Cushing’s disease (CD) with initial remission rate of 74% of which 10% relapsed. Approximately 36% manifested with active disease during the long-term follow-up (26% with persistent disease, 10% relapses) most of which were subjected to a secondary treatment (13.6% to pituitary resurgery, 14% to pituitary radiotherapy, and 5.4% to bilateral adrenalectomy). A total of 294 CD patients received medical therapy with overall remission rates for the most commonly used drugs: dopamine agonists 20%, pasireotide 30%, and ketoconazole 63%. Significant improvement of results was achieved by combining drugs with different mechanisms of action. Regardless of the progress in the neurosurgery and radiotherapy techniques and new drugs discovery, the management of patients with CS remains a real challenge for physicians. Not only patients with adrenal carcinoma but also significant percentage of subjects with persistent and recurrent Cushing’s disease often require a polymodal approach and the efforts of a multidisciplinary highly qualified, experienced, and motivated team in order to achieve a long-term remission.
A Meta-Analysis of the Associations Between the ATP-Binding Cassette Transporter ABCA1 R219K (rs2230806) Polymorphism and the Risk of Type 2 Diabetes in Asians
Authors: Jung Dongju , Cao Shihua , Liu Meiling , Park Sunmin 
Published: April 2018

AbstractAsians have relatively low insulin secretion capacity and readily develop type 2 diabetes mellitus (T2DM) when insulin resistant. For that reason, insufficient insulin secretion is critical factor for Asians at the early stage of T2DM. ATP-binding cassette transporter1 (ABCA1) is a membrane protein responsible for cholesterol efflux and its function is also important for secreting insulin in pancreatic β-cells. Given the importance of its role, different polymorphisms of ABCA1 gene might contribute differently to the development of T2DM. Here, we analyzed the association between a variant form of ABCA1 gene called ABCA1 rs2230806 and the prevalence of T2DM in a large sample size by pooling all of the case-control studies published. Relevant case-control studies were identified by searching PubMed, EMBASE, Cochrane Library, Korean scientific database, Chinese medical databases, and the Indian medical database. The association was evaluated using five genetic models such as the allelic (AG), recessive (RG), dominant (DG), homozygous (HMG), and heterozygous (HTG) genetic models. Heterogeneity of each genetic model was determined by the I2 test. A total of eight studies (7 published studies and one data set from the Korean Genetic Epidemiology Study) were eligible, satisfying Hardy–Weinberg equilibrium and included 2755 T2DM patients (case) and 16 635 nondiabetic subjects (control). All subjects in the studies were Asians. Each genetic model exhibited heterogeneity. In all genetic models, ABCA1 rs2230806 had a significant association with prevalence of T2DM: AG (OR=0.78, 95% CI: 0.61–0.98), RG (OR=0.72, 95% CI: 0.51–1.03), DG (OR=0.73, 95% CI: 0.55–0.97), HMG (OR=0.62, 95% CI: 0.41–0.96), and HTG (OR=0.78, 95% CI: 0.61–0.99). There was no single study that changed the overall effects in allelic genetic model with random effects. No publication bias existed in any models except the RG model. In conclusion, middle-aged and elderly adults with the minor allele of ABCA1 rs2230806 will have a lower risk of T2DM. This is the first meta-analysis to evaluate the association in Asians.
The Palmar Cutaneous Branch Mimicking the Recurrent Motor Branch of the Median Nerve
Authors: Wu Feiran , Ng Chye 
Published: April 2018

AbstractWe report an unusual anatomical variant of the palmar cutaneous branch (PCB) of the median nerve in a 46-year-old man presenting with recurrent carpal tunnel syndrome. At surgery, after neurolysis, the PCB was visualized arising at the level of the proximal margin of the transverse carpal ligament, mimicking the appearance of the recurrent motor branch. To date, there has been no description of this branch arising at this level. We aim to remind surgeons of this variation and highlight the importance of maintaining vigilance to avoid iatrogenic nerve injury.
Gender Differences in Peripheral Vascular Disease
Authors: Schramm Kristofer , Rochon Paul 
Published: April 2018

AbstractIn the past 20 years, peripheral artery disease (PAD) has been increasingly recognized as a significant cause of morbidity and mortality in the United States. PAD has traditionally been identified as a male-dominant disease; however, recent population trends and studies in PAD suggest that women are affected at least as often as men. Women comprise a larger population of the elderly than men, as well as an increasing proportion of patients with PAD. Much of the existing research on PAD has focused on whole populations, and gender-specific data on PAD is sparse. This review focuses on gender-specific differences in presentation, management, and outcomes of PAD intervention that are important considerations for the interventional radiologist.
Locoregional Therapies for the Treatment of Hepatic Metastases from Breast and Gynecologic Cancers
Authors: Mouli Samdeep , Gupta Ramona , Sheth Neil , Gordon Andrew , Lewandowski Robert 
Published: April 2018

AbstractBreast cancer is the most common women's malignancy in the United States and is the second leading cause of cancer death. More than half of patients with breast cancer will develop hepatic metastases; this portends a poorer prognosis. In the appropriately selected patient, there does appear to be a role for curative (surgery, ablation) or palliative (intra-arterial treatments) locoregional therapy. Gynecologic malignancies are less common and metastases to the liver are most often seen in the setting of disseminated disease. The role of locoregional therapies in these patients is not well reported. The purpose of this article is to review the outcomes data of locoregional therapies in the treatment of hepatic metastases from breast and gynecologic malignancies.
Pelvic Artery Embolization for Treatment of Postpartum Hemorrhage
Authors: Vogelzang Robert , Lindquist Jonathan 
Published: April 2018

AbstractPostpartum hemorrhage (PPH) is the leading cause of maternal perinatal morbidity and mortality worldwide. Defined as greater than 500 mL blood loss after vaginal delivery, and greater than 1,000 mL blood loss after cesarean delivery, PPH has many causes, including uterine atony, lower genital tract lacerations, coagulopathy, and placental anomalies. Correction of coagulopathy and identification of the cause of bleeding are mainstays of treatment. Medical therapies such as uterotonics, balloon tamponade, pelvic artery embolization, and uterine-sparing surgical options are available. Hysterectomy is performed when conservative therapies fail. Pelvic artery embolization is safe and effective, and is the first-line therapy for medically refractory PPH. A thorough knowledge of pelvic arterial anatomy is critical. Recognition of variant anatomy can prevent therapeutic failure. Pelvic embolization is minimally invasive, has a low complication rate, spares the uterus, and preserves fertility.
Report of the Third Family with Multiple Mitochondrial Dysfunctions Syndrome 5 Caused by the Founder Variant p.(Glu87Lys) in ISCA1
Authors: Shukla Anju , Kaur Parneet , Girisha Katta 
Published: April 2018

AbstractIron-sulfur cluster assembly 1 (ISCA1) is one of the essential proteins operating in the mitochondrial iron-sulfur (Fe-S) cluster biogenesis pathway. We reported the variant c.259G > A [p.(Glu87Lys)] in homozygous state in exon 4 of the ISCA1 gene as the likely cause of multiple mitochondrial dysfunction syndrome 5 in a previous publication. We now report the third patient with the same phenotype and variant, further supporting the possibility of a founder event. Our observation confirms the clinical presentation associated with a probable founder variant in this condition.
ICD-11: Neurokognitive Störungen
Authors: Jessen Frank , Frölich Lutz 
Published: April 2018

ZusammenfassungDie Sektion Neurokognitive Störungen im Kapitel 06 (Mental, Behavioural or Neurodevelopmental Disorders) löst in der 11. Revision der ICD (International
Statistical Classification of Diseases and Related Health Problems), aktuell in der Beta-Version vorliegend, das Kapitel F0 des ICD-10 ab. Es sind hier unter
anderem wesentliche Veränderungen in der Konzeptualisierung von neurodegenerativen Erkrankungen gegenüber der vorherigen Version vorgenommen worden. Zusätzlich
werden die neurodegenerativen Erkrankungen in dem Kapitel 08, (Diseases of the Nervous System) klassifiziert. Positiv ist, dass im Kapitel 06 das Konzept der
„organischen“ Störungen verlassen wurde und stattdessen auf erworbene Erkrankungen mit kognitiven Störungen als Leitsymptom fokussiert.Neben dem Delir und dem amnestischen Syndrom finden sich hier die Demenzen und die leichte neurokognitive Störung. Die ätiologische Klassifikation der Demenzen
richtet sich weiterhin nach syndromalen Kategorien aus. Eine Würdigung der neuen Biomarker-basierten ätiologischen Klassifikation der Alzheimer Krankheit ist
bisher nicht integriert. Die leichte neurokognitive Störung konnte zunächst keiner Ätiologie zugeordnet werden. Dies ist nun ergänzt worden und es besteht die
Möglichkeit, die leichte neurokognitive Störung z. B. mit der Alzheimer Krankheit zu assoziieren. Im Kapitel 08 des ICD-11 ist die Alzheimer Krankheit direkt
kodierbar, ohne dass diese mit einem spezifischen klinischen Syndrom verknüpft wird. Allerdings fehlt auch in diesem Kapitel der Bezug zu Biomarkern, so dass
unklar ist, wie die Alzheimer Krankheit diagnostiziert werden soll. Gleiches gilt für andere neurodegenerative Erkrankungen. Die alte syndromale
Herangehensweise im Kapitel 06 ist aus Sicht der Versorgung und der weltweiten Gültigkeit der ICD nachvollziehbar, da in vielen Regionen der Welt keine
Biomarker für neurodegenerative Erkrankungen zur Verfügung stehen und weil es bis heute nur syndromale Therapien gibt, welche auch nur im Demenzstadium der
Erkrankung wirksam ist. Gleichzeitig ist diese Klassifikation aber auch limitiert, da sie keinen molekular-diagnostischen Zugang bietet, was mit der Einführung
Pathologie-spezifischer Therapien in der Zukunft nicht vereinbar ist.
Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes
Authors: Gong Lili , Liu Fangyuan , Xiong Zhen , Qi Ruili , Luo Zhongwen , Gong Xiaodong , Nie Qian , Sun Qian , Liu Yun-Fei , Qing Wenjie , Wang Ling , Zhang Lan , Tang Xiangcheng , Huang Shan , Li Gen , Ouyang Hong , Xiang Mengqing , Nguyen Quan Dong , Liu Yizhi , Li David Wan-Cheng 
Published: April 2018

Significance
Oxidative stress-induced damage to retinal pigmented epithelial (RPE) cells is critically implicated in the pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness in the elderly. Here we report that oxidative stress-induced heterochromatin formation is essential to promote RPE survival. Mechanistically, oxidative damage-induced formation of heterochromatin occurs at the 53 target promoters of apoptosis genes and is regulated by p53 sumoylation. Our study demonstrates mechanistic links among chromatin conformation, p53 sumoylation, and RPE cell death. We propose that targeting heterochromatin provides a novel strategy for AMD treatment.
The dual origin of gesture
Authors: Boutet Dominique 
Published: April 2018

AbstractThis article questions some aspects ofMcNeill’s (2014)“imagistic” conception of gesture and his theory of the origin of language. In their stead, the article presents a kinesiological approach, and advances a hypothesis for a dual origin of symbolic gesture. The significance of the human artifactual environment in this context allows us to give precedence to brachial articulation over image. In nonhuman apes, the dyadic brachial origins of gestures show striking similarities in form and meaning to human brachial gestures. Manual gestures linked to object manipulation appeared as humankind acquired manual skills. These gestures express triadic values. Before speech, humans most probably already used dyadic symbolic gestures.
Military L2 immersion
Authors: Vincze Laszlo , Joyce Nick , Vehkalahti Kimmo 
Published: April 2018

Abstract
The purpose of the present study was to examine some of the motivations and longitudinal consequences of military service in L2
Swedish for L1 Finnish conscripts in Finland’s only Swedish language garrison. Cross-sectional data (N = 42),
analyzed with Bayesian path analysis, indicates that promotional instrumentality enhanced participants’ L2 ideal selves, but
integrative orientation did not. The L2 ideal self predicts L2 learning intentions in the army, but only among learners with low
L2 proficiency at the beginning of military service. Longitudinal data (N = 17), analyzed with a Bayesian model
selection procedure, shows that after six months in the army, participants reported higher levels of L2 proficiency, lower levels
of L2 use anxiety and more positive attitudes towards L2 speakers than at the beginning of military service.
The (pro)nominalizer -la(ŋ) in Tamangic
Authors: Honda Isao 
Published: April 2018

Abstract
As is well known, it is not uncommon in TB that nominalized clauses are used in various types of constructions, such as relative clauses, purpose clauses, verb complements, and free-standing independent clauses. Noonan (1997), for instance, shows the multi-functionality of the nominalized clause with a nominalizer -wa in Chantyal (Tamangic). The current article discusses another nominalizer -la(ŋ) in Tamangic. In many Tamangic languages/dialects the suffix la(ŋ) may be used to form possessive pronominal expressions (e.g. ‘someone’s/something’s one’). It can thus be more specifically described as a pronominalizer. There is evidence that in many Tamangic dialects the suffix has developed into a genitive marker. This paper further suggests a possibility that la(ŋ) is historically related to a number of verb suffixes, such as complementizers and finite verb suffixes used in free-standing independent clauses.
The Variation of Catalyst and Carrier Gas on Anisole Deoxygenation Reaction
Authors: Ariyani D , Nugrahaningtyas Khoirina Dwi , Heraldy E 
Published: April 2018

Abstract
This research aims to determine the best catalyst and carrier gas in anisole deoxygenation reaction. The reaction was carried out over a flow system with a variation of catalyst CoMo A (CoMo/USY reduction), CoMo B (CoMo/USY oxidation-reduction), and CoMo C (CoMo/ZAA oxidation-reduction). In addition, variation of carrier gas nitrogen and hydrogen was investigated. The result was analyzed using Gas Chromatography-Mass Spectroscopy (GC-MS). The deoxygenation anisole result showed that CoMo A catalyst with hydrogen as the carrier gas has the highest total product yield (50.72 %), intermediate product yield (38.49 % in phenol and 6.99 % in benzaldehyde), and deoxygenation yield (5.24 %). The CoMo C catalyst exhibited the most selective deoxygenation product. The nitrogen carrier gas with the CoMo C catalyst has the best selectivity of benzene product (93.92 %).
Efficient population-scale variant analysis and prioritization with VAPr
Authors: Birmingham Amanda , Mark Adam M , Mazzaferro Carlo , Xu Guorong , Fisch Kathleen M 
Published: April 2018

Abstract

Summary
With the growing availability of population-scale whole-exome and whole-genome sequencing, demand for reproducible, scalable variant analysis has spread within genomic research communities. To address this need, we introduce the Python package Variant Analysis and Prioritization (VAPr). VAPr leverages existing annotation tools ANNOVAR and MyVariant.info with MongoDB-based flexible storage and filtering functionality. It offers biologists and bioinformatics generalists easy-to-use and scalable analysis and prioritization of genomic variants from large cohort studies.

Availability and implementation
VAPr is developed in Python and is available for free use and extension under the MIT License. An install package is available on PyPi at https://pypi.python.org/pypi/VAPr, while source code and extensive documentation are on GitHub at https://github.com/ucsd-ccbb/VAPr.
MP-LAMP: parallel detection of statistically significant multi-loci markers on cloud platforms
Authors: Yoshizoe Kazuki , Terada Aika , Tsuda Koji 
Published: April 2018

Abstract

Summary
Exhaustive detection of multi-loci markers from genome-wide association study datasets is a computationally challenging problem. This paper presents a massively parallel algorithm for finding all significant combinations of alleles and introduces a software tool termed MP-LAMP that can be easily deployed in a cloud platform, such as Amazon Web Service, as well as in an in-house computer cluster. Multi-loci marker detection is an unbalanced tree search problem that cannot be parallelized by simple tree-splitting using generic parallel programming frameworks, such as Map-Reduce. We employ work stealing and periodic reduce-broadcast to decrease the running time almost linearly to the number of cores.

Availability and implementation
MP-LAMP is available at https://github.com/tsudalab/mp-lamp.

Supplementary information
Supplementary data are available at Bioinformatics online.
Modelling gear and fishers size selection for escapees, discards, and landings: a case study in Mediterranean trawl fisheries
Authors: Mytilineou Chryssi , Herrmann Bent , Mantopoulou-Palouka Danai , Sala Antonello , Megalofonou Persefoni 
Published: April 2018

Abstract
Gear selectivity and discards are important issues related to fisheries management but separately modelled. This work examines for the first time the overall size-selection pattern on the total amount of individuals of a species entering the trawl codend. An innovative approach was used based on modelling the escapement through the codend in the sea and the subsequently selection process by the fisher on the deck of the fishing vessel resulting into the discards and landings. Three different trawl codends and three species were investigated in the case study conducted. A dual sequential model accounting for both gear size-selectivity and the subsequent fisher-size-selectivity was applied, under the hypothesis that a fish entering the codend can follow a multinomial distribution with three probabilities, the escape, the discard and the landing probability, respectively. The model described the escape probability through the gear and the landing probability by the fisher as S-shaped curves leading to a bell-shaped curve for the discard probability affected by both gear and fisher selection. The model described well the experimental data in all cases. Sampling scheme of three compartments proved adequate. The model provides at the same time selectivity and discards parameters useful in fisheries management.
Transplant Drug Interactions and a Word of Caution for the HIV Provider. A Case Report
Authors: Hemmersbach-Miller Marion , Berg Carl L , Messina Julia A , Wolfe Cameron R 
Published: April 2018

Abstract
Electronic medical record platforms fail to support provider alerts when a drug is discontinued. Protease inhibitors, often boosted by ritonavir or cobicistat, increase the serum concentration of calcineurin inhibitors. This case demonstrates acute liver transplant rejection in an HIV-positive recipient due to a failure to recognize the loss of protease inhibitor interaction with his immunosuppressive regimen.