bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells
Authors: Eyking Annette , Ferber Frederike , Köhler Stefanie , Reis Henning , Cario Elke 
Published: August 2019

Abstract
Balanced control of innate immune signaling in the intestine represents an important host defense mechanism to avoid inappropriate responses that may exacerbate mucosal injury in acute inflammation. In this study, we report that TRIM58, a RING E3-ubiquitin ligase, associates with TLR2. The interaction was found in a yeast two-hybrid screen (human leukocyte and mononuclear library) and confirmed by coimmunoprecipitation of tagged and endogenous proteins. TRIM58 was predominantly expressed by murine and human myeloid-derived cells. Stimulation with a TLR2 ligand modulated TRIM58 synthesis in myeloid cells. Overexpression of TRIM58, but only in presence of the RING domain, promoted proteasome-dependent degradation of TLR2, inhibiting its signaling activity. Genetic deletion of Trim58 in mice (Trim58−/−) led to impaired resolution of acute dextran sodium sulfate–induced colitis, which was characterized by delayed recovery from colonic injury and associated with enhanced expression of TLR2 protein and proinflammatory cyto/chemokine production in inflamed colons. Using myeloid cell–specific deletion of Trim58 in mice, we demonstrated that the myeloid cell compartment was responsible for early colitis acceleration in Trim58 deficiency. In vitro studies revealed that Trim58−/− myeloid cells, which showed constitutive upregulation of TLR2 protein, overreacted to a proinflammatory milieu (TNF-α and IFN-γ) with increased IL-1β protein production, which mechanistically depended on Tlr2. Finally, we found that TRIM58 mRNA and protein expression levels were reduced in colonic specimens from patients with ulcerative colitis. In conclusion, we identify TRIM58 as a novel negative mediator of innate immune control and mucosal homeostasis via TLR2 signaling. Dysfunction of TRIM58 in myeloid cells may contribute to ulcerative colitis pathogenesis.
Brief communication: Preliminary hydro-meteorological analysis of the flash flood of 20 August 2018 in Raganello Gorge, southern Italy
Authors: Avolio Elenio , Cavalcanti Ottavio , Furnari Luca , Senatore Alfonso , Mendicino Giuseppe 
Published: August 2019

Abstract. On 20 August 2018 a flash flood affected the Raganello Creek
(southern Italy) causing 10 casualties. The rainfall event was so highly
localized that the spatial coverage of rain gauges were inadequate to
measure it, while radar products showed a storm cell with rain peaks of
about 70–100 mm h−1. This scientific report provides a preliminary
hydro-meteorological analysis of the event and evaluates the forecasting
skills of a system based on the WRF–WRF-Hydro models, using both one-way and
fully coupled approaches. The first results show a reasonable simulation of the
event in terms of both rainfall and hydrological impact.
CÁLCULO DA LARGURA OBJETIVA DA CALHA DO LEITO REGULAR DE UM CURSO D’ÁGUA USANDO VEÍCULO AÉREO NÃO TRIPULADO
Authors: Melo Emanuelle Zordan de , Silva Claudionor Ribeiro da 
Published: August 2019

As Áreas de Preservação Permanente (APPs), segundo o atual Código Florestal Brasileiro (CFB), são delimitadas a partir da largura da calha do leito regular do rio. Contudo, a medida da largura supracitada não é bem definida no CFB, apresentando subjetividade. Assim, o objetivo deste estudo é delimitar,de forma objetiva, a largura do leito regular. Para tanto, foram utilizadas imagens obtidas com um veículo aéreo não tripulado (VANT), aplicando técnicas de segmentação de imagens e o diagrama Voronoi. O experimento foi realizado em um trecho do Rio Uberabinha, Minas Gerais. A região deAPP medida com esse método apresentou diferenças de 5,18% em relação à APP obtida por meio de técnicas convencionais, que desconsideram a calha do leito regular dos corpos d’água. A vantagem do método proposto está na eliminação da subjetividade das técnicas convencionais, que usam uma aproximação para essa medida.
Introduction à l’oeuvre littéraire de Boubacar Boris Diop : du français au wolof
Authors: Diop Papa Samba 
Published: August 2019

Boubacar Boris Diop est l’auteur d’une riche oeuvre littéraire réalisée en deux langues : le français et le wolof. Le français est la langue héritée de la colonisation, et le wolof sa langue maternelle. Toutefois, il n’y a pas de conflits entre ces deux moyens d’expression, parce que tous les deux véhiculent le même message : celui de la priorité accordée à l’imaginaire wolof sur tout autre imaginaire, à commencer par celui du pays colonisateur : la France. Le présent article introduit à cette oeuvre bilingue, où l’auteur, un créateur puissant à l’esprit fertile touchant à l’essentiel des relations interculturelles entre l’Afrique et l’Occident, est aussi un auto-traducteur.
Dans les deux langues, Boubacar Boris Diop est un auteur militant pour la conservation de la mémoire culturelle sénégalaise (Doomi Golo et Bammeelu Kocc Bqarma), voire de la mémoire culturelle africaine (Murambi), voire encore de la mémoire négro-africaine avec la traduction en wolof d’Une saison au Congo d’Aimé Césaire : Nawetu deret.
Boubacar Boris Diop et ses publics, entre français et wolof, ancrage local et internationalisation de l’oeuvre
Authors: Carré Nathalie 
Published: August 2019

La question du public des écrivains africains se pose de manière récurrente. En effet, pour ceux d’entre eux qui publient au Nord, le lien avec les lecteurs de leur pays d’origine reste problématique. Or, le fait de « parler aux siens » est l’un des horizons manifestes, non de tous les écrivains, mais bien de ceux qui, tels Boubacar Boris Diop, se définissent comme des écrivains engagés. Cette contribution analyse la manière dont l’auteur, au fil d’un parcours éditorial varié, n’a cessé d’évoluer pour toucher un plus grand nombre de lecteurs africains, au premier rang desquels ses concitoyens sénégalais. Relativement bien publié en France mais aussi sur le sol africain, Boubacar Boris Diop a également fait le choix de passer du français au wolof pour sa création romanesque. Ce faisant, l’auteur-journaliste est aussi devenu professeur et éditeur, misant sur la construction, patiente et obstinée, d’un lectorat à venir. De cette façon, il développe également une oeuvre qui s’ancre localement sans pour autant disparaître à l’échelle internationale. Nous verrons ainsi comment, au fil de son parcours, se reconfigurent les rapports entre centre et périphérie, et ce, par le biais notable de la traduction.
Study on effect of introduced gas bubbles for the low channel damage in direct and alternating current liquid electrode plasma atomic emission spectrometry
Authors: Ruengpirasiri Prasongporn , Tue Phan Trong , Miyahara Hidekazu , Okino Akitoshi , Takamura Yuzuru 
Published: August 2019

Abstract
Liquid electrode plasma (LEP) is used as an excitation source for compact and sensitive elemental analysis, where the channel damage by plasma causes the severe tradeoff between sensitivity and lifetime. In alternative current (AC)-LEP, significantly less channel damage (1/3000) was reported compared to direct current LEP (DC-LEP). However, the mechanism has not been clear. In this paper, the effects of external gas introduction into AC-LEP and DC-LEP were studied. The results showed that the external gas bubbles facilitated stable and highly sensitive plasma generation with lower power, reducing channel damage and increasing the lifetime of the analysis chip. These effects are significant in Ar introduction and AC-LEP cases. The facts suggest that the lower damage in conventional AC-LEP without gas introduction is attributed to H2/O2 bubbles generated by hydrolysis at electrodes and consequently introduced into the LEP from outside of narrow channel.
The Effect of the International Court of Justice on Environmental Issues
Authors: Reza Annabi, Ali , Mahmoud Jalali, , Mahmood Seyyedvalilou Mir 
Published: August 2019

Environmental issues are an important in both domestic and international contexts, and may be subject to an International Court of Justice Decision, or any other international judicial institution. The International Court of Justice (ICJ) is the main judicial body of the United Nations, which has both a contentious and an advisory jurisdiction in its decisions. We study the Court's performance in environmental issues in this article. By examining four issues: first, the contentious and advisory tasks; second, the role of environmental organizations; third, the Trail Smelter case (between the United States and Canada), which is the legal basis of international law in the environmental issues, and; fourth, evaluating the Court's performance in eight judgments in the following cases: 1) The status of the environment in the court; 2) the Corfu case (between Albania and the United Kingdom); 3) the Lennox Lake case (between France and Spain); 4) the Mills case (between Uruguay and Argentina); 5) the Oder River case (between Poland and some European countries); 6) Aerial Herbicide Spraying (between Colombia and Ecuador). Because of the current contemporary status of international law and international environmental law, the International Court of Justice, has departed from their traditional approach because of the evolution of legal intellectual and thought on environmental issues. They focus on the general order of the international community as well as on pollution issues.
Static Mantle Density Distribution 1 Equation
Authors: Yun Tian Quan 
Published: August 2019

The study of mantle distribution does relate to the reflecting of seismic waves, and has important meaning. Using Archimedes Principle of Sink or Buoyancy (APSB), Newton’s gravitation, buoyancy, lateral buoyancy, centrifugal force and the Principle of Minimum Potential Energy (PMPE), we derive equation of static mantle density distribution. It is a set of double-integral equations of Volterra/Fredholm type. Some new results are: (1) The mantle is divorced into sink zone, neural zone and buoyed zone. The sink zone is located in a region with boundaries of a inclined line, with angle α1=35°15’ apex at 0(0,0,0) revolving around the z-axis, inside the crust involving the equator. The buoyed zone is located in the remainder part, inside the crust involving poles. The neural zone is the boundary between the buoyed and sink zones. The shape of core (in sink zone) is not a sphere. (2) The Potential energy inside the Earth is calculated by Newton’s gravity, buoyancy, centrifugal force and lateral buoyancy. (3) The gravitational acceleration above/on the crust is tested by formula with two parameters reflecting gravity and centrifugal force, and the phenomenon of “heavier substance sinks down in vertical direction due to attraction force, and moves towards to edges in horizontal direction due to centrifugal force” is tested by a cup of stirring coffee.
PERFORMANCE DE COAGULANTES ORGÂNICOS E INORGÂNICOS POR MEIO DE DIAGRAMA DE COAGULAÇÃO EM ÁGUAS NATURAIS
Authors: Silveira Thyago Nóbrega , Barbosa Maria Gabriella Negromonte , Pequeno Lucas Alves Batista , Dos Santos Whelton Brito , Ferreira Weruska Brasileiro 
Published: August 2019

<p>Este estudo teve como objetivo avaliar a performance dos coagulantes orgânicos e inorgânicos por meio de diagramas de coagulação, verificando as melhores condições de pH e dosagem para remoção de cor e turbidez, utilizando a água bruta do reservatório Epitácio Pessoa (Boqueirão, Paraíba). Foram realizados ensaios de coagulação/floculação/sedimentação em aparelho <em>jar test</em>, com o emprego de coagulantes orgânicos (Tanfloc SG e Tanfloc SL) e inorgânicos (sulfato de alumínio e cloreto férrico). A faixa de pH utilizada para a construção dos diagramas de coagulação para os coagulantes inorgânicos e orgânicos foram de 4,5 a 9,5 e 5,5 a 9,0, respectivamente, variando as dosagens dos coagulantes aplicadas na água. Com base nos diagramas de coagulação, observou-se que os flocos obtidos com os coagulantes orgânicos apresentaram velocidades de sedimentação maiores em comparação aos coagulantes inorgânicos, proporcionando melhor remoção dos sólidos suspensos, obtendo-se na etapa da decantação valores de turbidez inferiores a 0,5 uT em amplas faixas de pH.</p>
Musculoskeletal Symptomatic Areas After Total Knee Replacement for Osteoarthritis
Authors: Zhang MaryAnn , Selzer Faith , Losina Elena , Collins Jamie E. , Katz Jeffrey N. 
Published: August 2019

ObjectiveThe objective of this study was to measure cumulative incidence and incidence rate and identify factors associated with new musculoskeletal (MSK) symptomatic areas after total knee replacement (TKR) for osteoarthritis (OA).MethodsUsing data from a randomized controlled trial of patients undergoing elective TKR for OA, we assessed for MSK symptomatic areas by region (neck, hands/wrists/arms/shoulders, back, hips, nonindex knee, and ankles/feet) at baseline (pre‐TKR), and at 3, 6, 12, 24, 36, and 48 months post‐TKR. Cumulative incidence and incidence rates were calculated for each region. Factors associated with incident MSK symptomatic areas were identified using generalized linear mixed models. Time to incident symptomatic area was assessed using Cox proportional hazards regression.ResultsAmong 293 subjects, the cumulative incidence of any new MSK symptomatic area over 4 years was 45%; the incidence rate was 19.2 per 100 person‐years. Body site–specific cumulative incidence and incidence rates were highest for nonindex knee and back. Predictors of incident MSK symptomatic areas included female sex (relative risk [RR] 1.64; 95% confidence interval [CI] 1.15‐2.34), body mass index of 35 or higher (RR 1.27; 95% CI 0.88‐1.85), Charlson Comorbidity Index 2 or more (RR 1.28; 95% CI 0.92‐1.78), baseline index knee Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score greater than 40 (RR 1.39; 95% CI 0.99‐1.95), and anxiety/depression (measured by the five‐item Mental Health Index) (RR 1.70; 95% CI 1.20‐2.40).ConclusionIncident MSK symptomatic areas occurred in roughly half of recipients of TKR in the 4 years after the operation. Further study is needed to examine the long‐term impact of MSK symptomatic areas on postoperative pain, function, and quality of life.
Computationally Driven Discovery of a Family of Layered LiNiB Polymorphs
Authors: Gvozdetskyi Volodymyr , Bhaskar Gourab , Batuk Maria , Zhao Xin , Wang Renhai , Carnahan Scott L. , Hanrahan Michael P. , Ribeiro Raquel A. , Canfield Paul C. , Rossini Aaron J. , Wang Cai‐Zhuang , Ho Kai‐Ming , Hadermann Joke , Zaikina Julia V. 
Published: August 2019

AbstractTwo novel lithium nickel boride polymorphs, RT‐LiNiB and HT‐LiNiB, with layered crystal structures are reported. This family of compounds was theoretically predicted by using the adaptive genetic algorithm (AGA) and subsequently synthesized by a hydride route with LiH as the lithium source. Unique among the known ternary transition‐metal borides, the LiNiB structures feature Li layers alternating with nearly planar [NiB] layers composed of Ni hexagonal rings with a B–B pair at the center. A comprehensive study using a combination of single crystal/synchrotron powder X‐ray diffraction, solid‐state 7Li and 11B NMR spectroscopy, scanning transmission electron microscopy, quantum‐chemical calculations, and magnetism has shed light on the intrinsic features of these polymorphic compounds. The unique layered structures of LiNiB compounds make them ultimate precursors for exfoliation studies, thus paving a way toward two‐dimensional transition‐metal borides, MBenes.
Bio‐inspired Nonheme Iron Oxidation Catalysis: Involvement of Oxoiron(V) Oxidants in Cleaving Strong C−H Bonds
Authors: Kal Subhasree , Xu Shuangning , Que Lawrence 
Published: August 2019

AbstractNonheme iron enzymes generate powerful and versatile oxidants that perform a wide range of oxidation reactions, including the functionalization of inert C−H bonds, which is a major challenge for chemists. The oxidative abilities of these enzymes have inspired bioinorganic chemists to design synthetic models to mimic their ability to perform some of the most difficult oxidation reactions and study the mechanisms of such transformations. Iron‐oxygen intermediates like iron(III)‐hydroperoxo and high‐valent iron‐oxo species have been trapped and identified in investigations of these bio‐inspired catalytic systems, with the latter proposed to be the active oxidant for most of these systems. In this Review, we highlight the recent spectroscopic and mechanistic advances that have shed light on the various pathways that can be accessed by bio‐inspired nonheme iron systems to form the high‐valent iron‐oxo intermediates.
Mathematical model for thickness of off‐center spin‐coated polymer films
Authors: Wasapinyokul Kamol , Panjasamanwong Tanakrit , Ponkasemsuk Worathat , Sriprachuabwong Chakrit , Lomas Tanom 
Published: August 2019

ABSTRACTOff‐center spin coating is a method to fabricate thin film on a substrate where the substrate is located at an off‐center distance away from the rotating center of the spin coater. Here, a mathematical model to calculate the thickness of a film fabricated by an off‐center spin‐coating technique was developed and proposed. The model showed that the off‐center film thickness was calculable by using four factors—the on‐center film thickness, mass fraction of solid in the wet film, length of the substrate in the radial direction, and off‐center distance. Simply, the off‐center film thickness was inversely proportional to the off‐center distance to the exponent of one‐third, that is, the further the off‐center distance, the thinner the film. The model was verified where the thicknesses of the films calculated by using the model were compared with the experimental values obtained from the off‐center spin‐coated films of poly(vinylidene fluoride) at various off‐center distances. Both the modeled and the experimental data were of the same trend and in a good agreement with each other, indicating the validity of the model. The limitations of the model were also discussed. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48356.
Synthesis of pH‐responsive isolated soy protein/carboxymethyl chitosan microspheres for sustained pesticide release
Authors: Chen Long , Zhou Xinhua , Lin Guanquan , Chen Huayao , Hao Li , Zhou Hongjun 
Published: August 2019

ABSTRACTIn order to improve the utilization rate of avermectin (AVM), a complex was prepared by electrostatic self‐assembly using isolated soy protein (ISP) and carboxymethyl chitosan (CMCS) for loading AVM to obtain ISP/CMCS@AVM microspheres. The encapsulation efficiency (EE), sustained release property, ultraviolet (UV) protective ability, and toxicity of the microspheres were evaluated, and the release kinetics of AVM from the microsphere at different pHs were investigated. The results demonstrated that the average particle size of ISP/CMCS@AVM was 283.95 nm, and the EE reached 88.42% for AVM after denaturation. After 70 h of exposure to UV light, the residual rate of AVM in ISP/CMCS@AVM was 78.12%, which was significantly higher than 35.18% in the AVM emulsion. Moreover, the formulation imparted pH sensitivity and sustained‐release property to AVM and was consistent with the Korsmeyer–Peppas model, controlled by Fick diffusion. Finally, the insecticidal toxicity of ISP/CMCS@AVM did not differ significantly from that of unmodified AVM. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48358.
Metastatic breast cancer patients with lung or liver metastases should be distinguished before being treated with fulvestrant
Authors: He Min , Li Jun‐Jie , Zuo Wen‐Jia , Ji Lei , Jiang Yi‐Zhou , Hu Xi‐Chun , Wang Zhong‐Hua , Shao Zhi‐Ming 
Published: August 2019

AbstractBackgroundEndocrine therapy is the preferred treatment for patients with hormone receptor ‐positive metastatic breast cancer (MBC). While visceral metastasis is a negative prognostic factor, few studies have distinguished between the prognoses of patients with metastases at different visceral sites.Patients and methodsIn total, 398 patients receiving fulvestrant 500 mg at a single center over a 6‐year period were analyzed. Logistic regression models were used to identify the prognostic factors associated with progression‐free survival (PFS). Kaplan‐Meier analysis was used to compare the PFS of patients with lung and liver metastases.ResultsBaseline visceral metastases were present in 233 patients, including 138 with lungw/o liver metastases (lung metastases without liver involvement), 51 with liverw/o lung metastases (liver metastases without lung involvement) and 41 with lung and liver metastases. The median PFS was 6.8 months (5.6 and 9.2 months for visceral and nonvisceral metastases, respectively, P = .028). PFS was longer in patients with lungw/o liver metastases than in those with liverw/o lung metastases or lung and liver metastases (9.6, 3.7 and 3.2 months, respectively, P < .001; liverw/o lung vs. lungw/o liver hazard ratio (HR) 1.70; lung and liver vs. lungw/o liver HR 2.85). Patients with liver metastases experienced significantly worse PFS than those without liver involvement (3.7 vs. 9.2 months, P < .001). PFS benefits were observed in patients with longer disease‐free intervals, no liver metastases, and no previous chemotherapy.ConclusionFulvestrant treatment benefited patients with lungw/o liver or nonvisceral metastases. When treating hormone receptor‐positive/HER2‐negative MBC patients with endocrine therapy, it is important to differentiate patients with lung metastases from those with liver metastases.
The impact of the coronary sinus reducer upon left ventricular function in patients with refractory angina pectoris
Authors: Tzanis Georgios , Palmisano Anna , Gallone Guglielmo , Ponticelli Francesco , Baldetti Luca , Esposito Antonio , Colombo Antonio , Giannini Francesco 
Published: August 2019

AbstractObjectivesTo evaluate the impact of coronary sinus (CS) Reducer implantation upon left ventricular (LV) function.BackgroundCS Reducer implantation is associated with symptomatic relief in patients with refractory angina. The effects of the device upon left ventricular function remains unknown.MethodsPrior to device implantation and at 4‐months, resting ventricular volumes and function were measured using cardiac magnetic resonance (CMR). Stress CMR was performed to extract quantitative indices of myocardial perfusion (myocardial perfusion reserve index‐MPRI).ResultsNineteen patients (18 males, 66.0 [IQR 56.0–77.0] years), underwent successful Reducer implantation. Sixteen (84%) patients improved by at least 1 CCS class. Four months after Reducer implantation, we noticed a significant improvement in LV ejection fraction (LVEF) (61 [IQR 47–71] to 66 [IQR 57–72] %; p = .009), a reduction in LV end‐diastolic volume (LVEDV)/Body surface area (BSA) (65.7 [IQR 57.4–89.6] to 64.7 [IQR 53.7–74.1] mL/m2; p = .036) and a reduction in LV end‐systolic volume (LVESV)/BSA (28.7 [IQR 18.6–38.8] to 20.0 [IQR 15.0–31.4] mL/m2; p = .007). Patients with reduced EF (EF < 50%, n = 6) presented a greater increase of EF at follow up compared to patients with preserved EF (11.3 [IQR 6.5–54.5] vs. 3.8 [IQR 0.6–9.1] %; p = .029). The observed decrease in LVESV/BSA was greater in patients with reduced EF (23.6 [IQR 11.6–33.8] vs. 4.2 [IQR −2.0 to 8.4] mL/m2; p = .005). A significant increase in transmural MPRI was observed 4 months after Reducer implantation (p < .011).ConclusionsCS Reducer improved angina symptoms and improved left ventricular function. The improvement was pronounced in the subgroup of patients with reduced ejection fraction. Myocardial perfusion improvement could represent the underlying mechanism for the observed benefits.