bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemoradiotherapy and Subsequent Immunochemotherapy as Conversion Therapy in Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma: A Phase II NEXUS-1 Trial
Authors: Wang Xin , Kang Xiaozheng , Zhang Ruixiang , Xue Liyan , Xu Jiaqi , Zhao Xiaotian , Ou Qiuxiang , Yu Nuo , Feng Guojie , Li Jiao , Zheng Ziyu , Chen Xiankai , Wang Zhen , Zheng Qingfeng , Li Yong , Qin Jianjun , Bi Nan , Li Yin 
Published: November 2024

Abstract

Purpose:
This phase II trial investigated the safety and efficacy of chemoradiotherapy (CRT) followed by immunochemotherapy (iCT) and surgery in unresectable locally advanced esophageal squamous cell carcinoma (ESCC).

Patients and Methods:
Patients with unresectable locally advanced ESCC received radiotherapy (50 Gy/25f, 5 days/week) and nab-paclitaxel (100 mg on day 1/week) plus cisplatin (25 mg/m2 on day 1/week) for 5 weeks, followed by tislelizumab (200 mg on day 1/cycle) plus chemotherapy (nab-paclitaxel 150 mg/m2 and cisplatin 75 mg/m2 on day 2/cycle) for two 21-day cycles. Patients who converted to resectable underwent surgery 2 to 4 weeks afterward. The primary endpoint was a 1-year progression-free survival (PFS) rate.

Results:
Thirty patients were enrolled and underwent CRT (median follow-up: 21 months), of whom 24 received iCT. Twenty (66.7%) patients achieved resectability (R0: 95.2%; pathologic complete response: 65.0%; major pathologic response: 90.0%). One-year PFS and overall survival (OS) rates were 79.4% and 89.6%, respectively. The R0 resection group exhibited longer PFS (median, not reached vs. 8.4 months; HR = 0.28; 95% confidence interval, 0.08–0.84; P = 0.02) and OS (median, not reached vs. 19.2 months; HR = 0.18; 95% confidence interval, 0.04–0.73; P &lt; 0.01) than the nonsurgery group. Grade 3 to 4 adverse events were observed in 11 (11/30, 36.7%) patients, and immune-related pneumonitis was observed in 5 (5/24, 20.8%) patients. Post-CRT minimal residual disease before surgery was associated with unfavorable PFS and OS.

Conclusions:
Our study met the primary endpoint. Conversion CRT and subsequent iCT followed by surgery was a promising treatment strategy for unresectable locally advanced ESCC.
Divergent Clinical and Immunologic Outcomes Based on STK11 Co-mutation Status in Resectable KRAS-Mutant Lung Cancers Following Neoadjuvant Immune Checkpoint Blockade
Authors: Rosner Samuel , Connor Sydney , Sanber Khaled , Zahurak Marianna , Zhang Tianbei , Gurumurthy Isha , Zeng Zhen , Presson Brad , Singh Dipika , Rayes Roni , Sivapalan Lavanya , Pereira Gavin , Ji Zhicheng , Thummalapalli Rohit , Reuss Joshua E. , Broderick Stephen R. , Jones David R. , Deutsch Julie S. , Cottrell Tricia R. , Chaft Jamie E. , Spicer Jonathan , Taube Janis , Anagnostou Valsamo , Brahmer Julie R. , Pardoll Drew M. , Ji Hongkai , Forde Patrick M. , Marrone Kristen A. , Smith Kellie N. 
Published: November 2024

Abstract

Purpose:
Co-mutations of the Kirsten rat sarcoma virus (KRAS) and serine/threonine kinase 11 (STK11) genes in advanced non–small cell lung cancer (NSCLC) are associated with immune checkpoint blockade (ICB) resistance. Although neoadjuvant chemoimmunotherapy is now a standard-of-care treatment for resectable NSCLC, the clinical and immunologic impacts of KRAS and STK11 co-mutations in this setting are unknown.

Experimental Design:
We evaluated and compared recurrence-free survival of resectable KRAS-mutated NSCLC tumors, with or without co-occurring STK11 mutations, treated with neoadjuvant ICB. Single-cell transcriptomics was performed on tumor-infiltrating T cells from seven KRASmut/STK11wt tumors and six KRAS and STK11 co-mutated (KRASmut/STK11mut) tumors.

Results:
Relative to KRASmut/STK11wt tumors, KRASmut/STK11mut exhibited significantly higher recurrence risk. Single-cell transcriptomics showed enhanced oxidative phosphorylation with evidence of decreased prostaglandin E2 signaling and increased IL-2 signaling in CD8+ tumor-infiltrating lymphocytes (TIL) from KRASmut/STK11mut tumors, a finding that was mirrored in KRASwt tumors that relapsed. TILs from KRASmut/STK11mut tumors expressed high levels of molecules associated with tumor residence, including CD39 and ZNF683 (HOBIT).

Conclusions:
These divergent T-cell transcriptional fates suggest that T-cell maintenance and residence may be detrimental to antitumor immunity in the context of neoadjuvant ICB for resectable NSCLC, regardless of KRAS mutation status. Our work provides a basis for future investigations into the mechanisms underpinning prostaglandin E2 signaling and IL-2 signaling as they relate to T-cell immunity to cancer and to divergent clinical outcomes in KRASmut/STK11mut NSCLC treated with neoadjuvant ICB.
Translating Indian Algebra in the Seventeenth Century: ʿAtāʾollāh Roshdi’s Persian Version of Bhāskara II’s Bījagaṇita
Authors: Karimian Zeinab 
Published: November 2024

Abstract
One of the most important works in the field of medieval Indian mathematics corresponding to algebra is Bījagaṇita (Seed Calculation), a Sanskrit treatise by the famous mathematician and astronomer Bhāskara II (or Bhāskarācārya, c. 1114–aft. 1183). This paper is a general overview of the Tarjoma-ye Bij ganet (The Translation of the Bījagaṇita, 1634), a Persian text composed by the mathematician ʿAtāʾollāh Roshdi (or Rashidi), who served at the court of the Mughal emperor Shāh Jahān (r. 1628–58). The translation is divided into an introduction, subdivided in six chapters (bāb), and five books (maqāla). After discussing both Bhāskara II and Roshdi, I compare the latter’s translation with the original Sanskrit text on the basis of available English translations. I will also demonstrate how an intermediate language, which played an important role in the connection of South Asian scientific sources, facilitated this translation.
ʿAbd Al-Jabbār and Bāqillānī on the Meaning of Miracles (Muʿjizāt): a Study of Convergences and Divergences
Authors: Jaffer Tariq 
Published: November 2024

Abstract
This article presents the technical terminology, concepts, and theological principles developed by Bāqillānī and ʿAbd al-Jabbār in Kitāb al-Bayān and the Mughnī (respectively). It traces the convergences and divergences in their approaches to the word muʿjiz and describes the parallel methodological processes through which they critique postulates established by the “language users or experts” (ahl al-lugha). I argue that we can better understand how the meaning of the word muʿjiz was contested in medieval Islam and how its semantic range was established by reading Muʿtazilī (ʿAbd al-Jabbār) and Ashʿarī-Sunnī (Bāqillānī) texts alongside one another. An examination of how claims to the authority over the meaning of the word muʿjiz are made and the social significance of such claims are also central themes of this study.
Unearthing the Genizah of the Jewish Community in Figuig
Authors: Gillot Laurence , Olszowy-Schlanger Judith 
Published: November 2024

Abstract
Within the framework of an agreement with the National Institute of Sciences of Archaeology and Heritage (INSAP) of Morocco and with the Municipality of Figuig, a multidisciplinary team of Moroccan and French researchers, led by Saghir Mabrouk (INSAP), Laurence Gillot (MCF Paris Cité, UMR 8210 ANHIMA), and André Del (Paris Val-de-Seine School of Architecture, EVCAU) has carried out inventory, research and valorization of the heritage of the oasis of Figuig since 2005. In this context, excavations were conducted in the mellah of the qsar Loudaghir, one of the quarters inhabited by the Jewish community which left in 1970. The discovery of manuscripts in the genizah of the mellah has led archaeologists to refer to palaeographers and epigraphists to inventory, study and preserve these manuscripts. This article accounts for the dialogue established between archaeology and philology.
Should I Be Worried? Worry in Dunhuang Divination
Authors: Zhao Lu 
Published: November 2024

Abstract
The emotional aspect of divination has rarely been systematically addressed in the history of Chinese divination. Focusing on divination manuals from Dunhuang 敦煌, this article examines the interaction between emotions, especially worry, and divination in medieval China. It explores, on the one hand, how worry in the medieval context drove individuals to seek divinatory practices. On the other hand, it examines how the divination manuals used worry and other emotive words as part of their technical language to measure uncertainty. Surveying different usages of the terms for worry in these manuals, the article argues that the language of worry was part of the terminology of Dunhuang divination, serving as a heuristic to help the inquirers sense the level of auspiciousness and uncertainty of future scenarios. The article will also show that emotional words form a unique layer of terminology that conveys to inquirers a specific sense of auspiciousness.
ProbSevere Version 3: Improved Exploitation of Data Fusion and Machine Learning for Nowcasting Severe Weather
Authors: Cintineo John L. , Pavolonis Michael J. , Sieglaff Justin M. 
Published: November 2024

Abstract
National Oceanic and Atmospheric Administration (NOAA)/Cooperative Institute for Meteorological Satellite Studies (CIMSS) ProbSevere, or the “probability of severe” models, provide next-hour probabilistic guidance on severe weather in the United States (large hail, strong wind gusts, and tornadoes) using machine learning and meteorological data from remotely sensed platforms and short-term numerical weather models. ProbSevere has been widely used by NOAA’s National Weather Service (NWS) since 2016. ProbSevere version 3 employs multiplatform, multiscale storm object identification and tracking to collect storm features and then uses gradient boosting decision trees to make predictions of convective hazards from the extracted predictors. ProbSevere v3 was trained, validated, and tested on data from 2018 to 2023. Results demonstrate improved performance over ProbSevere v2 for the majority of the United States across all seasons, spanning a wide range of meteorological regimes. The greatest improvements are for the hail, wind, and any severe models, whereas the tornado model demonstrated modest improvement. ProbSevere v3 models were evaluated by NWS forecasters in simulated real-time experiments from 2021 to 2023. The majority of forecasters preferred ProbSevere v3 over v2 due to improved confidence in predictions and greater lead times for the issuance of severe weather warnings. An analysis of predictor importance revealed several radar, lightning, satellite, and numerical model fields that strongly contribute to the model predictions, which is consistent with past research and knowledge of severe thunderstorm forecasting. This reinforces the importance of environmental data fusion for nowcasting severe weather associated with midlatitude convection.

Significance Statement
This study details the updates made to a U.S.-wide, real-time, probabilistic severe-weather guidance system aimed to improve forecaster confidence and the accuracy of the U.S. National Weather Service severe weather warnings. An evaluation of the system demonstrated improved performance over the operational predecessor, which was driven by radar, ground-based lightning, satellite, and numerical model data sources.
The Many Faces of Guilt: A Review Mapping Unique and Overlapping Expressions in OCD and Depression
Authors: Ganguly Oindrila , Tarafder Sreemoyee 
Published: November 2024

Background: Guilt, a complex emotional experience pervading many lives, takes on an intricate form when intertwined with psychiatric conditions. As a multifaceted concept, guilt represents a key diagnostic feature in depression and is an integral part of obsessive compulsive disorder (OCD). Methods: This systematic review aimed to synthesize empirical research on the varied dimensions of guilt across these two mental illnesses, where guilt is emphasized as a pathognomonic factor. A systematic computer-based literature search was conducted, using a rigorous set of eligibility criteria and specific keyword combinations to ensure relevant and exhaustive coverage of the topic. Following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, a comprehensive literature search spanning multiple databases identified 12 eligible studies on guilt in OCD and 8 in depression. Findings: The findings revealed 20 distinct guilt constructs measured across the two disorders. Notably, 5 unique guilt subtypes and 15 themes for OCD and 6 exclusively studied guilt for depression emerged, reflecting potential disorder-specific manifestations of guilt. Conclusion and Implication: Delineating such guilt profiles holds the potential to untangle the role of guilt in the onset, perpetuation, and clinical course of OCD and depression. This comprehensive mapping of guilt constructs provides an empirical foundation for elucidating disorder-specific pathways influenced by guilt, thereby informing the development of targeted psychological interventions tailored to the distinct guilt patterns underpinning these debilitating conditions.
Satisfactory Clinical Outcomes After Latissimus Dorsi Tendon Transfer for Irreparable Posterosuperior Massive Rotator Cuff Tears: A 10- to 20-Year Follow-up
Authors: Kany Jean , Madoki Alexandre , Duerinckx Quentin , Miranda Luis Alfredo , van Rooij Floris , Saffarini Mo , Grimberg Jean 
Published: November 2024

Background: Latissimus dorsi tendon transfer (LDTT) leads to good clinical outcomes and recovery of function. A previous study have evaluated the outcomes of LDTT at a minimum 10-year follow-up and found durable improvements in shoulder function and pain relief but observed that shoulders with fatty infiltration of the teres minor muscle and insufficiency of the subscapularis muscle tended to have inferior results. Purpose: To evaluate the outcomes of LDTT with a minimum follow-up of 10 years in a sizeable cohort for the treatment of irreparable posterosuperior massive rotator cuff tears (mRCTs). Study Design: Case series; Level of evidence, 4. Methods: Patients who underwent LDTT for irreparable mRCTs between 2004 and 2013, performed by the same senior surgeon, were included in this study. All intraoperative and postoperative complications, as well as whether patients required conversion to reverse shoulder arthroplasty (RSA), were noted. At a minimum follow-up of 10 years, an independent observer collected range of motion measurements and clinical scores, including those for the Constant score, the Subjective Shoulder Value, and a visual analog scale for pain; the subacromial space was also assessed. Results: A total of 143 patients (147 shoulders) that underwent LDTT, with a minimum follow-up of 10 years, were included; of these, 24 patients (24 shoulders, 16%) were lost to follow-up, 1 patient (1 shoulder, 0.7%) died 9 years after the index procedure for reasons unrelated to shoulder surgery, and 18 patients (18 shoulders, 12%) required conversion to RSA, of which 6 underwent conversion at ≥6 years after LDTT. The remaining 101 patients (104 shoulders), including 3 patients who were scheduled to undergo RSA, were assessed at a mean time of 12.3 ± 2.2 years (range, 10-20 years) after index LDTT, comprised 52 men (53 shoulders) and 49 women (51 women) and had a mean age of 61.6 ± 8.0 years (range, 39-81 years) at the time of index surgery. Complications were noted in 14 shoulders, of which 4 required a reoperation. The Constant score improved by 34.2 ± 11.7 points, the adjusted Constant score by 43.5 ± 15.3 points, and the Subjective Shoulder Value score by 50.4 ± 16.4 points. The subacromial space decreased by 0.3 ± 2.0 mm. Conclusion: At a minimum follow-up of 10 years, LDTT for the treatment of irreparable posterosuperior mRCTs led to satisfactory clinical scores. Of the 147 shoulders that underwent LDTT, 18 (12%) required conversion to RSA.
Subscapularis Muscle Radiographic Integrity and Patient-Reported Outcomes Following Arthroscopic Anatomic Glenoid Reconstruction With Distal Tibial Allograft
Authors: Castillo de la Peña Jose , Chalmers Peter N. , Ma Jie , Wong Ivan 
Published: November 2024

Background: Shoulder stabilization surgery has evolved over time, and bony augmentation procedures on the glenoid side are being performed more often. The Latarjet procedure modifies subscapularis anatomy because the conjoined tendon divides the subscapularis muscle fibers through a split/takedown, which has structural and functional implications. Arthroscopic anatomic glenoid reconstruction (AAGR) re-creates anatomy. This technique uses the Halifax portal to deploy and fix a distal tibial allograft (DTA) through the rotator interval, thus preserving the subscapularis anatomy. Purpose/Hypothesis: The purpose was to analyze the radiographic properties of the subscapularis muscle after AAGR. It was hypothesized that the subscapularis muscle structure remains preserved postoperatively. Study Design: Case series; Level of evidence, 4. Methods: A retrospective review was performed comprising a consecutive series of patients treated with AAGR with DTA between November 2012 and April 2021 for traumatic anterior shoulder instability with glenoid bone loss. Patients were excluded if they had posterior instability, glenoid fracture, missing pre- or postoperative computed tomography (CT) scans, or only CT arthrogram available. Radiographic variables measured on CT scans included estimates of subscapularis muscle volume, subscapularis/infraspinatus muscle ratio, and fatty infiltration according to the Goutallier classification. Pre- and postoperative Western Ontario Shoulder Instability index scores were collected as a secondary outcome of this study. Results: Ninety-three patients were included in the study with a clinical follow-up of 2.3 ± 1.5 years (mean ± SD). The subscapularis volume increased from 185.91 ± 45.85 mL preoperatively to 194.1 ± 49.0 mL postoperatively ( P = .006). The subscapularis to infraspinatus muscle ratio showed a significant increase from 0.96 ± 0.27 to 1.05 ± 0.30 after surgery ( P = .002). All patients had a Goutallier stage of 0 before and after surgery. The Western Ontario Shoulder Instability scores showed a significant improvement from 64.8 ± 15.5 preoperatively to 28.2 ± 24.0 postoperatively ( P < .001). Conclusion: Patients who undergo AAGR with DTA for traumatic shoulder instability with glenoid bone loss have a preserved subscapularis muscle volume with no fatty infiltration, while showing a significant improvement in clinical outcomes.
Effect of Patient Resilience on Functional Outcomes After Anterior Cruciate Ligament Reconstruction
Authors: Hanna Adeeb Jacob , Davis Gaston , Muchintala Rahul , He Alice , Bryan Sean , Tjoumakaris Fotios P. , Freedman Kevin B. 
Published: November 2024

Background: Previous studies have examined the relationship between patient resilience and functional outcome scores after anterior cruciate ligament reconstruction (ACLR). However, past studies have failed to explore the longitudinal relationship between preoperative resilience and functional outcomes 2 years after ACLR. Purpose: To evaluate the relationship between preoperative patient resilience and functional outcomes 2 years after ACLR. Study Design: Cohort study; Level of evidence, 3. Methods: Patients were identified who underwent ACLR for anterior cruciate ligament tears between January and June 2020 at a single institution. Those who completed the Brief Resilience Scale preoperatively as part of routine patient questionnaires were considered for inclusion. Patients were contacted a minimum of 2 years after ACLR to complete the short form of the Knee injury and Osteoarthritis Outcome Score (KOOS-JR), Single Assessment Numeric Evaluation (SANE), International Knee Documentation Committee (IKDC) Subjective Knee Form, and visual analog scale (VAS). Outcomes were compared among patients with low resilience (LR), normal resilience (NR), and high resilience (HR), as defined in a previous study.23 Results: A total of 81 patients were included in the final analysis, with 14 patients in the low preoperative resilience group, 54 in normal, and 13 in high. The mean age of the cohort was 32.0 years, and there were no significant differences in age, sex, race, graft type, or psychiatric comorbidities among the resilience groups. Significantly increased postoperative KOOS-JR scores were observed in patients in the HR group as compared with those in the NR and LR groups (94.8, 86.7, and 79.6, respectively; P = .031). There were also significantly increased postoperative SANE scores in patients in the HR group versus those in the NR and LR groups (92.3, 83.5, and 69.2; P = .012). Patients with high preoperative resilience achieved the IKDC Patient Acceptable Symptom State at significantly higher rates ( P = .003). No significant differences were observed in postoperative VAS ( P = .364), IKDC ( P = .072), or change in IKDC ( P = .448) over time among resilience groups. Postoperatively, 30 patients (37.0%) changed resilience groups, with 13 moving down and 17 moving up in category (low, n = 12; normal, n = 55; high, n = 14). Conclusion: Preoperative resilience correlated with KOOS-JR and SANE scores 2 years after ACLR but did not correlate with VAS, IKDC, or change in IKDC over the same period. Resilience was not static, with changes in resilience observed from initial to final evaluations. Resilience is not a strong predictor of postoperative patient-reported outcomes after ACLR.
Clinical Correlates of Antipsychotic Plasma Levels with Long-Acting Paliperidone: Corrélats cliniques des concentrations plasmiques de palipéridone à libération prolongée
Authors: Zipursky Robert B. , Agid Ofer , Kiang Michael , Remington Gary 
Published: November 2024

Objectives The majority of patients with schizophrenia experience dramatic improvement in psychotic symptoms when treated with antipsychotic medication. Maintenance treatment can prevent relapses but problems with medication adherence limit effectiveness. Long-acting injectable antipsychotics (LAIs) provide an opportunity to establish adherence but challenges remain in ensuring that the dose selected is therapeutic. Therapeutic drug monitoring has not been established as valuable for LAIs in the maintenance treatment of schizophrenia. This exploratory study was undertaken to describe plasma paliperidone levels in outpatients treated with the LAI paliperidone palmitate and to determine whether paliperidone levels are associated with subjective experience on medication and side effects. Methods Twenty-one outpatients with schizophrenia receiving treatment with LAI paliperidone consented to participation in this study. Blood samples were obtained for measurement of paliperidone and prolactin levels at the first visit. A second paliperidone level was obtained at the time of the next injection for 18 of the participants. Clinical rating scales were administered at the first visit to assess illness severity, attitudes regarding medication, subjective well-being and side effects. Results Paliperidone levels were highly correlated at the two time points (ρ = .85; P < .001). Mean paliperidone level at the first visit was 34.9 ng/ml and ranged from 5.1 to 73.9 ng/ml. Higher paliperidone levels were correlated with higher prolactin levels (ρ = 0.59, P < .01) and lower sexual desire (ρ = −.58, P < .01). Conclusions We demonstrated that paliperidone levels can be measured reliably in patients receiving LAI paliperidone. Higher plasma levels were associated with higher prolactin levels and reduced sexual desire but not with measures of subjective experience on medications or other side effects. Measurement of paliperidone levels in patients treated with paliperidone palmitate may have the potential to minimize the dose of medication prescribed and, in turn, the severity of sexual side effects.