bluuebunny/crossref_metadata_2025_split huggingface dataset:
ІНТЕГРОВАНИЙ ABC/FMR/VED-АНАЛІЗ РЕАЛІЗАЦІЇ ПРОСТАТОПРОТЕКТОРІВ (НА ПРИКЛАДІ АПТЕЧНОЇ МЕРЕЖІ)
Authors: Gadyak I. V. , Hromovyk B. P. , Grytsyk A. R. , Popovych V. P. 
Published: April 2018

Мета роботи. Здійснити наглядний розподіл простатопротекторів (ПП) за обсягом товарообігу з одночасною ідентифікацією частоти їх роздрібної реалізації залежно від важливості ПП для фармакотерапії.Матеріали і методи. Матеріалами дослідження були ЛЗ із терапевтичної підгрупи G04C «Препарати для лікування доброякісної гіперплазії передміхурової залози». Місце дослідження – аптечна мережа ТзОВ «Іва-Фарм» (м. Івано-Франківськ), до складу якої входить 21 аптека і 10 аптечних пунктів. Період дослідження – 2017 р. Методологія дослідження ґрунтувалася на інтегрованому АВС/FMR/VED-аналізі.Результати й обговорення. За даними реалізації ПП аптечною мережею за 2017 р. виявлено, що глибина їх асортименту становила 26 позицій або 33,3 % від зареєстрованих ПП в Україні. Шляхом ABC-аналізу встановлено 10 найважливіших ПП за обсягом реалізації у вартісному показнику (серед них 4 формулярних ПП), а за даними FMR-аналізу – 8 найважливіших ПП за обсягом реалізації у натуральному показнику (серед них 5 формулярних ПП). За допомогою формального VED-аналізу визначено, що більшість ПП є життєво необхідними. При цьому частка реалізованих неформулярних (бажаних) ПП у вартісному показнику становить менше половини, а в натуральному показнику – третину. Унаслідок інтегрованого ABC/FMR/VED-аналізу визначено три найважливіші формулярних ПП за обсягом реалізації у вартісному і натуральному показниках, а саме: Омнік капс. № 30, Флосін 0,4 мг № 30, Аводарт 0,5 мг № 90.Висновки. Результати інтегрованого АВС/FMR/VED-аналізу роздрібної реалізації ПП можуть слугувати базою для прийняття рішень щодо збалансованості асортименту ПП в аптечній мережі. Висока частка реалізації неформулярних ПП у вартісному та натуральному показниках вказує на необхідність проведення моніторингу доцільності застосування таких ЛЗ та обмеження необґрунтованих призначень неформулярних ПП шляхом підвищення ефективності інформаційної роботи серед лікарів-урологів.
Resection of Medial Talocalcaneal Coalition With Interposition of a Pediculated Flap of Tibialis Posterior Tendon Sheath
Authors: Hubert Jan , Hawellek Thelonius , Beil Frank Timo , Saul Dominik , Kling Jens Henning , Viebahn Christoph , Jungesblut Oliver , Stücker Ralf , Rupprecht Martin 
Published: April 2018

Background: The purpose of the study was to present a novel operative technique in the management of medial talocalcaneal coalition (TC) and to report our clinical and radiologic results after interposition of a pediculated flap (PF) of the tibialis posterior tendon sheath. Methods: Twelve feet of 10 patients with a medial TC were treated with the interposition of PF of the tibialis posterior tendon sheath following resection. Pre- and postoperative clinical examinations were performed to evaluate the range of motion and the function of the tibialis posterior muscle of the affected foot. Pain was registered by visual analog scale (VAS) and the function of the foot by the American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score. The mean follow-up duration was 57.2 months (SD ±37.2 range 12-128) after surgery. Magnetic resonance imaging (MRI) was carried out to assess the outcome. Results: All patients reported a significant reduction of pain ( P = .002) at the final follow-up. The activity level had improved since the operation, and the subtalar joint motion was increased, but no weakness of the tibialis posterior muscle could be observed. The AOFAS hindfoot score was significantly improved ( P = .002). MRI did not reveal any migration of the tibialis posterior tendon sheath, and the interposed PF was confirmed at the resection zone. Furthermore, no TC relapse or ruptures of the functional anatomical structures could be observed. Conclusion: The resection combined with the interposition of a PF of the tendon sheath seems to avoid relapse of TC and improves symptoms and the function of the foot. Level of Evidence: Level IV, case series.
Bullous Pemphigoid: A 10-Year Study of Discordant Results on Direct Immunofluorescence
Authors: Fudge Jessica G. , Crawford Richard I. 
Published: April 2018

Background: Bullous pemphigoid (BP) is the most common subepidermal autoimmune disorder characterized by tense bullae. It is associated with circulating autoantibodies against BP antigen-1 and BP antigen-2. Diagnosis is based upon clinical, histopathologic, and immunopathologic examination. Direct immunofluorescence (DIF) of perilesional skin highlights C3 with or without IgG in a linear pattern along the basement membrane. Objectives: We hypothesized that repeat biopsies may be required for a definitive DIF diagnosis of BP, as initial DIF evaluation may result in a false-negative result. Methods: A retrospective chart review was conducted on 1143 specimens collected for evaluation for BP. Cases from 2 Vancouver Coastal Health Authority laboratories from 2006 to 2016 were reviewed. Results were interpreted as positive, negative, or indeterminate based on pathologic description and specimen quality. Results: After meeting the inclusion criteria, 739 specimens were further evaluated. There were 289 cases of BP in the 10-year period. Five patients (1.73%; 95% confidence interval [CI], 1.50-1.96) required a second biopsy to support a BP diagnosis, and within this group, 1.04% of the 289 (95% CI, 0.811-1.27) were true successive negative-to-positive DIF results. Conclusions: DIF is the most reliable test used to diagnose BP; however, a small percentage of patients will initially have a negative result. False-negative or indeterminate results may be due to specimen sampling from lesional skin or due to a subthreshold quantity of immune complexes in the skin. Repeat biopsy is warranted despite an initial negative DIF if BP is clinically suspected.
A link between expression level of long-non-coding RNA ZFAS1 in breast tissue of healthy women and obesity
Authors: Mansoori Yaser , Tabei Mohammad Bagher , Askari Alireza , Izadi Pantea , Daraei Abdolreza , Naghizadeh Mohammad Mehdi , Zendehbad Zahra , Bastami Milad , Nariman-Saleh-Fam Ziba , Mansoori Hosein , Tavakkoly-Bazzaz Javad 
Published: April 2018

Background: Epidemiological and experimental literature indicates that the risk of breast cancer incidence is strongly linked to hormone-dependent factors, including reproductive history and obesity. However, the molecular mechanisms underlying the association between these factors and breast cancer risk are poorly understood. The aim of this study, therefore, was to determine whether obesity and reproductive history are associated with expression levels of two breast cancer-related long non-coding RNAs (lncRNAs), namely ZFAS1 and SRA1 in cancer-free breast tissues of women. Methods: In the current research, 145 healthy women were recruited, and the quantitative expression levels of the two lncRNAs were determined through qPCR assay after gathering the mammoplasty breast tissue samples. Results: It was found that women with body mass index (BMI)≥30 kg/m2 and BMI 25–29 kg/m2 show a low expression of ZFAS1 compared to the BMI<25 kg/m2 ( P=0.031 and P=0.027, respectively). Then, the correlation analysis disclosed a negative correlation of ZFAS1 low expression with increasing BMI (r=−0.194, P=0.019). Interestingly, this analysis demonstrated a negative correlation between low expression of the ZFAS1 and high BMI in women with menarche age below 14 (r=−221; P=0.028). Lastly, it was also revealed that there was a negative association of the low expression level of ZFAS1 with increasing BMI in women through regression models (B=−0.048, P=0.019). Conclusions: These findings suggest interesting clues about the links between high BMI and the expression levels of ZFAS1 in non-diseased breasts that may help us better understand the underlying mechanisms through which obesity contributes to breast carcinogenesis. However, such results need more validations in future research.
Particulated Autograft Cartilage Implantation for the Treatment of Osteochondral Lesions of the Talus: A Novel Technique
Authors: Delman Connor , Wuellner John , Kreulen Chris , Lundeen Gregg , Giza Eric 
Published: April 2018

Osteochondral lesions of the talus often occur following ankle sprains and fractures. Operative intervention is typically required because of the diminished intrinsic repair capability of talar articular cartilage. Several techniques have evolved that emphasize replacing the defect with cartilage that closely mimics the biological properties of hyaline articular cartilage. The goals of operative treatment are resolution of symptoms, physiologic healing, and restoration of function while eliminating the need for further intervention. This article describes a novel, single-step technique for the treatment of osteochondral lesions of the talus with the use of particulated autograft cartilage implantation. Levels of Evidence: Level V
Temporal trends in secondary prevention in myocardial infarction patients discharged with left ventricular systolic dysfunction in Poland
Authors: Gasior Mariusz , Gierlotka Marek , Pyka Łukasz , Zdrojewski Tomasz , Wojtyniak Bogdan , Chlebus Krzysztof , Rozentryt Piotr , Niedziela Jacek , Jankowski Piotr , Nessler Jadwiga , Opolski Grzegorz , Hoffman Piotr , Jankowska Ewa , Polonski Lech , Ponikowski Piotr 
Published: April 2018

Background The proportion of patients discharged after myocardial infarction with left ventricular systolic dysfunction remains high and the prognosis is unfavourable. The aim of this study was to analyse the temporal trends in the treatment and outcomes of a nationwide cohort of patients. Methods and results Data from the Polish Registry of Acute Coronary Syndromes and Acute Myocardial Infarction in Poland Registry were combined to achieve complete information on inhospital course, treatment and outcomes. An all-comer population of patients discharged with left ventricular ejection fraction of 40% or less formed the sample population ( n = 28,080). The patients were analysed for the incidence of significant temporal trends and their possible consequences. The implementation of guideline-based treatment at discharge was high. In the post-discharge course a trend towards a higher frequency of percutaneous coronary intervention and a lower prevalence of planned coronary artery bypass grafting procedures was observed. The number of implantable cardioverter defibrillator/cardiac resynchronisation therapy defibrillator implantations was increasing. Cardiac rehabilitation was performed in 19–23% cases. The post-discharge outpatient care was based on general practitioner visits, with only 47.9–48.1% of patients attending an ambulatory cardiology specialist visit. In 12 months of observation the frequency of heart failure rehospitalisations was 17.5–19.1%, while the prevalence of rehospitalisations due to myocardial infarction decreased (8.3% in 2009 to 6.7% in 2013, P < 0.001). A trend towards lower all-cause mortality was observed. Assessment of composite outcomes (death, myocardial infarction, stroke or heart failure rehospitalisation) adjusted for sex and age at 12 months revealed a significant decreasing trend. Conclusion The overall prognosis in this population is improving slowly. This may be due to the increasing prevalence of guideline-based forms of secondary prevention. Efforts aimed at maintaining these trends are essential, as overall compliance with these guideline remains suboptimal.
Surgical Outcomes and Limitations of Decompression Surgery for Degenerative Spondylolisthesis
Authors: Sugiura Tsuyoshi , Okuda Shinya , Matsumoto Tomiya , Maeno Takafumi , Yamashita Tomoya , Haku Takamitsu , Iwasaki Motoki 
Published: April 2018

Study Design: A retrospective study. Objectives: To investigate surgical outcomes and limitations of decompression surgery for degenerative spondylolisthesis. Methods: One hundred patients with degenerative spondylolisthesis who underwent decompression surgery alone were included in this study. The average follow-up period was 3.7 years. Radiography and magnetic resonance imaging were used for radiological assessment. Patients with a recovery rate of >50% throughout the study period were classified as the control group (Group C), while those with a recovery rate of <50% throughout the study period were classified as the poor group (Group P). Patients that had improved symptoms, and yet later showed neurological deterioration due to foraminal stenosis at the same level were classified as the exiting nerve root radiculopathy group (Group E), while those who showed deterioration due to slip progression at the same level were classified as the traversing nerve root radiculopathy group (Group T). Results: Patient distribution in each group was 73, 12, 7, and 8 in Groups C, P, E, and T, respectively. As for preoperative radiological features, slippage and an upper migrated disc in Group P, disc wedging and an upper migrated disc in Group E, and lamina inclination and posterior opening in Group T were evident. The cutoff value of preoperative slippage with a poor outcome was 13%. Conclusions: Surgical outcomes of decompression surgery for degenerative spondylolisthesis were successful in 73% cases. Preoperative radiological features for poor outcomes were slippage of more than 13%, an upper migrated disc, disc wedging, and lamina inclination.
Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer
Authors: Koppula Pranavi , Zhang Yilei , Zhuang Li , Gan Boyi 
Published: April 2018

AbstractCancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as xCT). SLC7A11 promotes cystine uptake and glutathione biosynthesis, resulting in protection from oxidative stress and ferroptotic cell death. Recent studies have unexpectedly revealed that SLC7A11 also plays critical roles in glutamine metabolism and regulates the glucose and glutamine dependency of cancer cells. This review discusses the roles of SLC7A11 in regulating the antioxidant response and nutrient dependency of cancer cells, explores our current understanding of SLC7A11 regulation in cancer metabolism, and highlights key open questions for future studies in this emerging research area. A deeper understanding of SLC7A11 in cancer metabolism may identify new therapeutic opportunities to target this important amino acid transporter for cancer treatment.
Stalking risks to celebrities and public figures
Authors: Wilson Simon , Dempsey Charles , Farnham Frank , Manze Tony , Taylor Alice 
Published: April 2018

SUMMARYProminent figures are frequently subjected to unwanted and intrusive attentions. Such stalking behaviour is often driven by psychotic illness, angrily blaming the public figure for delusional persecution (resentful motivation), or based on erotomanic delusions (intimacy seeking motivation), for example. This behaviour can cause psychological harm to both perpetrator and victim, and is unlawful. In the rare instances where a public figure has been attacked, the perpetrator has usually had a history of such stalking behaviour and of severe mental illness. For these reasons, early identification and diversion into appropriate care and treatment will be for the benefit of both parties and will prevent more serious violence in a minority of cases. The importance of the provision of education to improve both reporting rates by victims and an appropriate response from the criminal justice system is highlighted. A multi-agency approach involving the criminal justice system and mental health services is the most effective means of achieving these aims.DECLARATION OF INTERESTNone.LEARNING OBJECTIVES•Learn that severe mental illness, particularly psychosis, is often an important driver of stalking behaviour•Learn that delusional disorder is a treatable mental illness•Appreciate that prevention rather than prediction is the approach to managing the risks of high-harm low-probability outcomes.
Mother and Baby Units matter: improved outcomes for both
Authors: Stephenson Lucy A. , Macdonald Alastair J. D. , Seneviratne Gertrude , Waites Freddie , Pawlby Susan 
Published: April 2018

BackgroundMother and Baby Units (MBUs) are usually preferred by patients and clinicians. Current provision is limited, although expansion is in progress. To ensure successful investment in services, outcome measurement is vital.AimsTo describe maternal outcomes, mother–infant outcomes and their relationship in one MBU.MethodPaired maternal Brief Psychiatric Rating Scale (BPRS) scores, Health of the Nation Outcome Scales (HoNOS) scores and Crittenden CARE-Index (CCI) mother–infant interaction data were collected at admission and discharge.ResultsThere were significant improvements in BPRS (n = 152), HoNOS (n = 141) and CCI (n = 62) scores across diagnostic groups. Maternal BPRS scores and mother–infant interaction scores were unrelated. Improvement in maternal HoNOS scores was associated with improved maternal sensitivity and reduction in maternal unresponsiveness and infant passiveness.ConclusionsPositive outcomes were achieved for mothers and babies across all diagnostic groups. Reduction in maternal symptoms, as measured by BPRS, does not necessarily confer improvement in mother–infant interaction. MBU treatment should focus on both maternal symptoms and mother–infant interaction.Declaration of interestNone.
ПЕРСПЕКТИВЫ РАЗВИТИЯ НЕПОСРЕДСТВЕННОЙ ДЕМОКРАТИИ С УЧЕТОМ СОВРЕМЕННЫХ ИНФОРМАЦИОННЫХ ТЕХНОЛОГИЙ
Authors: Beydina Tatiana Evgenievna , Denisov Yuri Vladimirovich , Kuharsky Artem Nikolaevich 
Published: April 2018

Статья посвящена определению понятия и выявлению сущности демократии как основы современного государственного устройства и важнейшего фактора динамики современного общества. Проведенное исследование позволяет выделить следующие перспективы в отношении российской демократии:1. Демократия предполагает признание принципа равенства и свободы всех людей, активное участие народа в политической жизни страны, непосредственное осуществление власти народом.2. Демократический режим складывается лишь в государствах, где достигнут высокий уровень социально-экономического развития, способный обеспечить необходимое благосостояние всем гражданам.3. Очевидно, что демократический режим для российского общества является самым оптимальным в нынешних условиях, и это обусловлено в первую очередь многонациональностью населения России.Научная новизна состоит в обосновании механизма взаимосвязи демократии и современных информационных технологий, среди которых выделяются: упрощённая схема взаимодействия с государственными органами, свободный доступ к информации для населения, электронная очередь, портал государственных услуг, рассекречивание отдельных аспектов политики, в том числе личных данных (кредитные карты, банковские операции, частная жизнь политиков).Цель – выявить эффективность демократии как представительства народа в новых информационных условиях.Методы или методология проведения работы: прогнозный метод, планирование и прогнозирование, сравнительный метод при характеристике демократии и нанодемократии, метод ранжирования, системный метод (обновление демократии), информационные технологии.Результаты: охарактеризовать перспективы существующей в Российской федерации системы демократии, разработать модель представительства народа, как более эффективную в условиях применения сетевых компьютерных технологий и сохранения индивидуальных прав и свобод человека.Область применения результатов: целесообразно применять в государственной информационной политике.
Routine pre- and post-neoadjuvant chemotherapy fitness testing is not indicated for oesophagogastric cancer surgery
Authors: Drummond RJ , Vass D , Wadhawan H , Craig CF , MacKay CK , Fullarton GM , Forshaw MJ 
Published: April 2018

Introduction There is a known correlation between anaerobic threshold (AT) during cardiopulmonary exercise testing and development of cardiopulmonary complications in high-risk patients undergoing oesophagogastric cancer surgery. This study aimed to assess the value of routine retesting following neoadjuvant chemotherapy. Methods Patients undergoing neoadjuvant chemotherapy with subsequent oesophagogastric cancer surgery with pre- and post-neoadjuvant chemotherapy cardiopulmonary exercise data were identified from a prospectively maintained database. Measured cardiopulmonary exercise variables included AT and maximum oxygen uptake at peak exercise (VO2 peak). Anaerobic threshold values within 1 ml/kg/minute were considered static. Patients were grouped into AT ranges of less than 9 ml/kg/minute, 9–11 ml/kg/minute and greater than 11 ml/kg/minute. Outcome measures were unplanned intensive care stay, postoperative cardiovascular morbidity and mortality. Results Between May 2008 and August 2017, 42 patients from 675 total resections were identified, with a mean age of 65 years (range 49–84 years). Mean pre-neoadjuvant chemotherapy AT was 11.07 ml/kg/minute (standard deviation, SD, 3.24 ml/kg/minute, range 4.6–19.3 ml/kg/minute) while post-neoadjuvant chemotherapy AT was 11.19 ml/kg/minute (SD 3.05 ml/kg/minute, range 5.2–18.1 ml/kg/minute). Mean pre-neoadjuvant chemotherapy VO2 peak was 17.13 ml/kg/minute, while post-chemotherapy this mean fell to 16.59 ml/kg/minute. Some 44.4% of patients with a pre-chemotherapy AT less than 9 ml/kg/minute developed cardiorespiratory complications compared with 42.2% of those whose AT was greater than 9 ml/kg/minute (P = 0.914); 63.6% of patients in the post-neoadjuvant chemotherapy group with an AT less than 9 ml/kg/minute developed cardiorespiratory complications. There was no correlation between direction of change in AT and outcome. Conclusion In our patient population, neoadjuvant chemotherapy does not appear to result in a significant mean reduction in cardiorespiratory fitness. Routine pre- and post-neoadjuvant chemotherapy cardiopulmonary exercise testing is currently not indicated; however, larger studies are required to demonstrate this conclusively.
Writing around Paterson: Critical urban poetics in Williams, Olson and Ginsberg
Authors: Mickelson Nate 
Published: April 2018

Abstract
William Carlos Williams, Charles Olson and Allen Ginsberg wrote ambitious city poems in the 1940s and 1950s. They were in close contact at the time, reviewing each other’s work in small-circulation journals and exchanging ideas in person and by letter. This article traces the circulation of influence among the three poets and interprets their poems – Paterson (Williams 1992), The Maximus Poems (Olson 1993), and Ginsberg’s ‘Shrouded Stranger’ poems, including ‘Howl’ (Ginsberg 1984; 1994; 2006) – in relation to other forms of critical urban discourse. Specifically, the article suggests that Williams, Olson and Ginsberg recognized the abstract rationality of Paterson Books I–IV as a limitation of the poem and sought to develop alternative approaches. Their responses anticipate critiques of rational-comprehensive city planning and urban renewal by Guy Debord, Herbert Gans and Jane Jacobs. Comparing Debord, Gans and Jacobs’s arguments to representations of the city in Paterson, The Maximus Poems, and Ginsberg’s ‘Shrouded Stranger’ shows the centrality of the city to innovative twentieth-century poetics and suggests that city poetry can be read as a mode of critical urban analysis.