bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of a simulation-based training in hand hygiene with alcohol-based hand rub in emergency departments
Authors: Ghazali Aiham Daniel , Deilhes Elsa , Thomas Julie , Laland Catherine , Thévenot Sarah , Richer Jean Pierre , Oriot Denis 
Published: October 2018

AbstractBackgroundHand hygiene is the primary measure for reducing nosocomial infections based on 7 steps recommended by the WHO. The aim of this study was to assess the duration and the quality of hand hygiene before and after simulation-based training (SBT).MethodsThe study took place in a University Hospital Pediatric Department among its residents and nurses. In assessment A, 10 hand-rubbing procedures per participant during a work day were scored by observers using a validated, anatomically based assessment scale. Two weeks later, all participants received a didactic course and SBT, followed 1 month later by assessment B, observation of 10 hand-rubbing procedures. Assessments were performed by 2 independent observers. Before-and-after testing was used to evaluate the demonstration of theoretical knowledge.ResultsIn total, 22 participants were included, for whom 438 hand hygiene procedures were assessed: 218 for assessment A and 220 for assessment B. The duration of hand rubbing increased from 31.16 seconds in assessment A to 35.75 seconds in assessment B (P=.04). In assessment A, participants averaged 6.33 steps, and in assessment B, participants averaged 6.03 steps (difference not significant). Significant improvement in scores was observed between assessments A and B, except for the dorsal side of the right hand. The wrist and interdigital areas were the least-cleaned zones. A difference between assessments A and B was observed for nail varnish (P=.003) but not for long nails or jewelry. Theoretical scores increased from 2.83 to 4.29 (scale of 0–5; P<.001).ConclusionThis study revealed that an optimal number of steps were performed during hand-rubbing procedures and that SBT improved the duration and quality of hand hygiene, except for the dorsal right side. Emphasis should be placed on the specific hand areas that remained unclean after regular hand-rubbing procedures.
New data from Jebel Moya and Shaqadud (central Sudan): implications for Late Mesolithic interconnectivity with the Sahara
Authors: Brass Michael , Adam Ahmed H. A. , Wellings Joss 
Published: October 2018

AbstractBuilding upon Brass’ previous research on Jebel Moya, which included a comprehensive reanalysis of the pottery from Wellcome's 1911–14 expeditions curated at the British Museum, new research activities by the University College London–University of Khartoum–NCAM Expedition to the Southern Gezira project have included locating and examining for the first time the Late Mesolithic sherds from Jebel Moya curated at the National Museum in Khartoum. Representative samples from the sites of Shaqadud Midden and Shaqadud S21 at the British Museum have also been re-examined. The aims of these activities were threefold: to test the reliability and cohesiveness of and patterning in the Shaqadud collection through the expanded application of attribute analysis, to determine if Caneva's observations of décor patterns on Jebel Moya's Late Mesolithic sherds could be replicated and to obtain better visibility into the nature of its pottery assemblage from this time, and to use the resulting data to test the viability of the central Sudan being a fulcrum of cultural interchanges during the late sixth and early fifth millennium BC. We conclude that there was a piecemeal establishment of networks along which there was diffusion of ideas and animals, and perhaps low numbers of people, into the central and south-central Sudan.
The drivers and consequences of unstablePlasmodiumdynamics: a long-term study of three malaria parasite species infecting a tropical lizard
Authors: Otero Luisa , Schall Jos J. , Cruz Virnaliz , Aaltonen Kristen , Acevedo Miguel A. 
Published: October 2018

AbstractUnderstanding the consequences of environmental fluctuations for parasite dynamics requires a long-term view stretching over many transmission cycles. Here we studied the dynamics of three malaria parasites (Plasmodium azurophilum,P. leucocyticaandP. floridense) infecting the lizardAnolis gundlachi, in the rainforest of Puerto Rico. In this malaria–anole system we evaluated temporal fluctuations in individual probability of infection, the environmental drivers of observed variation and consequences for host body condition andPlasmodiumparasites assemblage. We conducted a total of 15 surveys including 10 from 1990 to 2002 and five from 2015 to 2017. During the early years, a lizard's probability of infection by allPlasmodiumspecies appeared stable despite disturbances ranging from two hurricanes to short droughts. Over a longer timescale, probability of infection and overall prevalence varied significantly, following non-linear relationships with temperature and rainfall such that highest prevalence is expected at intermediate climate measures. A perplexing result was that host body condition was maximized at intermediate levels of rainfall and/or temperature (when risk of infection was highest), yet we found no significant decreases in body condition due to infection.Plasmodiumparasite species composition varied through time with a reduction and near local extinction ofP. floridense. Our results emphasize the need for long-term studies to reveal host–parasite dynamics, their drivers and consequences.
CoStorm: a term map system to aid in a collaborative ideation process
Authors: Zhang Chengwei , López-Parra Marcelo , Chen Junyu , Tian Ling 
Published: October 2018

AbstractThe decisions made during the early stages of a design process have a huge impact on a product. Owing to the explosion of preliminary ideas, however, designers easily lose track of important ideas and significant information and end up being buried in a pile of plain words. Failing to locate an idea in the context of idea generation makes it difficult to generate new ideas or take optimized decisions. In this study, the authors propose the term map approach to provide a complete bird's eye view of all ideas, which is a higher-dimension graphical representation that helps in inspiring ideas and making decisions among design team members. A software application named CoStorm is developed. Through the case study of the cash-flattener module, which is a crucial component of an automated teller machine, this method is found to contribute in facilitating the ideation and decision-making progress.
Frontal Subduction of the Mid‐Atlantic Bight Shelf Water at the Onshore Edge of a Warm‐Core Ring
Authors: Zhang Weifeng G. , Partida Jacob 
Published: October 2018

AbstractThis work studies the subduction of the shelf water along the onshore edge of a warm‐core ring that impinges on the edge of the Mid‐Atlantic Bight continental shelf. The dynamical analysis is based on observations by satellites and from the Ocean Observatories Initiative Pioneer Array observatory as well as idealized numerical model simulations. They together show that frontogenesis‐induced submesoscale frontal subduction with order‐one Rossby and Froude numbers occurs on the onshore edge of the ring. The subduction flow results from the onshore migration of the warm‐core ring that intensifies the density front on the interface of the ring and shelf waters. The subduction is a part of the cross‐front secondary circulation trying to relax the intensifying density front. The dramatically different physical and biogeochemical properties of the ring and shelf waters provide a great opportunity to visualize the subduction phenomenon. Entrained by the ring‐edge current, the subducted shelf water is subsequently transported offshore below a surface layer of ring water and alongside of the surface‐visible shelf‐water streamer. It explains the historical observations of isolated subsurface packets of shelf water along the ring periphery in the slope sea. Model‐based estimate suggests that this type of subduction‐associated subsurface cross‐shelfbreak transport of the shelf water could be substantial relative to other major forms of shelfbreak water exchange. This study also proposes that outward spreading of the ring‐edge front by the frontal subduction may facilitate entrainment of the shelf water by the ring‐edge current and enhances the shelf‐water streamer transport at the shelf edge.
Long-term succession in a coal seam microbiome during in situ biostimulation of coalbed-methane generation
Authors: Beckmann Sabrina , Luk Alison W S , Gutierrez-Zamora Maria-Luisa , Chong Nur Hazlin Hazrin , Thomas Torsten , Lee Matthew , Manefield Michael 
Published: October 2018

Abstract
Despite the significance of biogenic methane generation in coal beds, there has never been a systematic long-term evaluation of the ecological response to biostimulation for enhanced methanogenesis in situ. Biostimulation tests in a gas-free coal seam were analysed over 1.5 years encompassing methane production, cell abundance, planktonic and surface associated community composition and chemical parameters of the coal formation water. Evidence is presented that sulfate reducing bacteria are energy limited whilst methanogenic archaea are nutrient limited. Methane production was highest in a nutrient amended well after an oxic preincubation phase to enhance coal biofragmentation (calcium peroxide amendment). Compound-specific isotope analyses indicated the predominance of acetoclastic methanogenesis. Acetoclastic methanogenic archaea of the Methanosaeta and Methanosarcina genera increased with methane concentration. Acetate was the main precursor for methanogenesis, however more acetate was consumed than methane produced in an acetate amended well. DNA stable isotope probing showed incorporation of 13C-labelled acetate into methanogenic archaea, Geobacter species and sulfate reducing bacteria. Community characterisation of coal surfaces confirmed that methanogenic archaea make up a substantial proportion of coal associated biofilm communities. Ultimately, methane production from a gas-free subbituminous coal seam was stimulated despite high concentrations of sulfate and sulfate-reducing bacteria in the coal formation water. These findings provide a new conceptual framework for understanding the coal reservoir biosphere.
Reversible and nonvolatile manipulation of the electronic transport properties of topological insulators by ferroelectric polarization switching
Authors: Zhao Xu-Wen , Dong Si-Ning , Gao Guan-Yin , Xu Zhi-Xue , Xu Meng , Yan Jian-Min , Zhao Wei-Yao , Liu Yu-Kuai , Yan Shu-Ying , Zhang Jin-Xing , Wang Yu , Lu Hai-Zhou , Li Xiao-Guang , Furdyna J. K. , Luo Hao-Su , Zheng Ren-Kui 
Published: October 2018

AbstractReversible and nonvolatile electric-field control of the physical properties of topological insulators is essential for fundamental research and development of practical electronic devices. Here, we report the integration of topological insulator films with ferroelectric Pb(Mg1/3Nb2/3)O3-PbTiO3 (PMN-PT) single crystals in the form of ferroelectric field-effect devices that allow us to tune the electronic properties of topological insulator films in a reversible and nonvolatile manner. Specifically, gating of Cr-doped Bi2Se3 films with the PMN-PT layer is shown to provide a means to reversibly tune and modulate the carrier density and carrier type, as well as its other properties, such as the conductance, magnetoconductance, Fermi level, phase coherence length, and screening factor of electron–electron interaction by polarization switching at room temperature. These findings provide a simple and direct approach for probing the quantum transport properties of topological insulator films through ferroelectric gating by using PMN-PT. The combination of topological insulators with both ferroelectrically and piezoelectrically active PMN-PT thus offers a promising step toward exploring topological insulator/ferroelectric(piezoelectric) hybrid devices that could utilize not only the ferroelectric field-effect of topological insulator/PMN-PT structures but also the unique properties of respective materials.
Genotype × Environment interactions of Nagina22 rice mutants for yield traits under low phosphorus, water limited and normal irrigated conditions
Authors: Poli Yugandhar , Balakrishnan Divya , Desiraju Subrahmanyam , Panigrahy Madhusmitha , Voleti Sitapati Rao , Mangrauthia Satendra Kumar , Neelamraju Sarla 
Published: October 2018

AbstractMulti environment testing helps identify stable genotypes especially for adverse abiotic stress situations. In the era of climate change and multiple abiotic stresses, it becomes important to analyze stability of rice lines under both irrigated and stress conditions. Mutants are an important genetic resource which can help in revealing the basis of natural variation. We analyzed 300 EMS induced mutants of aus rice cultivar Nagina22 (N22) for their G × E interaction and stability under low phosphorus (P), water limited and irrigated conditions. Environmental effect and interaction were more significant than genotypic contribution on grain yield (GY), productive tillers (TN) and plant height (PH) under these three environmental conditions in dry season, 2010. GY and TN were more affected by low P stress than by water limited condition, but PH was not significantly different under these two stresses. Mutants G17, G209, G29, G91, G63 and G32 were stable for GY in decreasing order of stability across the three environments but G254 and G50 were stable only in low P, G17 and G45 only in water limited and G295 and G289 only in normal irrigated condition. We then selected and evaluated 3 high yielding mutants, 3 low yielding mutants and N22 for their stability and adaptability to these 3 environments in both wet and dry seasons for six years (2010–2015). The most stable lines based on the combined analysis of 12 seasons were G125 (NH210) under normal condition, G17 (NH686), G176 (NH363) and G284 (NH162) in low P condition and G176 (NH363) under water limited condition. G176 was the best considering all 3 conditions. When screened for 15 Pup1 gene-specific markers, G176 showed alleles similar to N22. While two other low-P tolerant lines G17 and G65 showed N22 similar alleles only at k-1 and k-5 but a different allele or null allele at 13 other loci. These stable mutants are a valuable resource for varietal development and to discover genes for tolerance to multiple abiotic stresses.
Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation
Authors: Nguyen Ngan N. T. , Lim Yun-Sook , Nguyen Lap P. , Tran Si C. , Luong Trang T. D. , Nguyen Tram T. T. , Pham Hang T. , Mai Han N. , Choi Jae-Woong , Han Sang-Seop , Hwang Soon B. 
Published: October 2018

AbstractHepatitis C virus (HCV) exploits an extensive network of host proteins to maintain chronic infection. Using RNA-Seq technology, we identified 30 host genes that were differentially expressed in cell culture grown HCV (HCVcc)-infected cells. Of these candidate genes, we selected solute carrier family 3 member 2 (SLC3A2) for further investigation. SLC3A2, also known as CD98hc, is a member of the solute carrier family and encodes a subunit of heterodimeric amino acid transporter. SLC3A2 and LAT1 constitute a heterodimeric transmembrane protein complex that catalyzes amino acid transport. In this study, we showed that HCV upregulated both mRNA and protein expression levels of SLC3A2 and this upregulation occurred through NS3/4A-mediated oxidative stress. HCV also elevated SLC3A2/LAT1 complex level and thus mammalian target of rapamycin complex 1 (mTORC1) signaling was activated. We further showed that L-leucine transport level was significantly increased in Jc1-infected cells as compared with mock-infected cells. Using RNA interference technology, we demonstrated that SLC3A2 was specifically required for the entry step but not for other stages of the HCV life cycle. These data suggest that SLC3A2 plays an important role in regulating HCV entry. Collectively, HCV exploits SLC3A2 for viral propagation and upregulation of SLC3A2 may contribute to HCV-mediated pathogenesis.
Using Neuroimaging to Detect Covert Awareness and Determine Prognosis of Comatose Patients: Informing Surrogate Decision Makers of Individual Patient Results
Authors: Graham Mackenzie , Doherty Colin , Naci Lorina 
Published: October 2018

AbstractRobust prognostic indicators of neurological recovery are urgently needed for acutely comatose patients. Functional neuroimaging is a highly sensitive tool for uncovering covert cognition and awareness in behaviorally nonresponsive patients with prolonged disorders of consciousness, and may be applicable to acutely comatose patients. Establishing a link between early detection of covert awareness in acutely comatose patients and eventual recovery of function could have significant implications for patient prognosis, treatment, and end-of-life decisions. Because functional neuroimaging of acutely comatose patients is currently limited to the research context, ethical guidelines for disseminating a patient's individual research results to clinical teams and surrogate decision makers are needed. We propose an ethical framework composed of four conditions that can guide ethical disclosure of individual results of neuroimaging research in the acute care context.
Contiguous Metastasis of Pulmonary Adenocarcinoma to Meningioma
Authors: Nakaya Masato , Kurebayashi Yutaka , Mochizuki Youichi , Fukaya Raita , Fukuchi Masahito , Fujii Koji , Ichimura Shinya 
Published: October 2018

Background Metastasis from one tumor into another is known as tumor-to-tumor metastasis. We report a case of a contiguous occurrence of meningioma and brain cancer metastasis.
Patient A 91-year-old woman presented with a sudden onset of weakness in her right limbs and gait disturbance. Fourteen years previously, she had a tumor that was suspected to be a meningioma in the left frontal convexity with no change for several years. One year earlier to presentation she was diagnosed with lung carcinoma in the left lower lobe.
Results Magnetic resonance images revealed enlargement of the tumor with perifocal edema. Histologic examination showed a meningioma with contiguous metastatic poorly differentiated adenocarcinoma, as well as a clearly defined border between the two components. The clinical origin of the metastasis was presumed to be from the left lower lobe of the lung.
Conclusion Although our case does not strictly fulfill the definition of tumor-to-tumor metastasis, we suggest a contiguous occurrence develops by the same mechanism and may be a subtype of this process. Although previous reports suggested the loss of epithelial cadherin (E-cadherin) expression in the recipient tumor as the cause of contiguous metastasis, E-cadherin expression was positive in our case and did not seem to be involved in the localization of the metastasis.
Trap Crops and Insectary Plants in the Order Brassicales
Authors: Badenes-Pérez Francisco Rubén 
Published: October 2018

AbstractThis paper reviews the most important cases of trap crops and insectary plants in the order Brassicales. Most trap crops in the order Brassicales target insects that are specialist in plants belonging to this order, such as the diamondback moth, Plutella xylostella L. (Lepidoptera: Plutellidae), the pollen beetle, Meligethes aeneus Fabricius (Coleoptera: Nitidulidae), and flea beetles in the genera Phyllotreta and Psylliodes (Coleoptera: Chrysomelidae). In most cases, the mode of action of these trap crops is the preferential attraction of the insect pest for the trap crop located next to the main crop. With one exception, these trap crops in the order Brassicales have been used with brassicaceous crops. Insectary plants in the order Brassicales attract a wide variety of natural enemies, but most studies focus on their effect on aphidofagous hoverflies and parasitoids. The parasitoids benefiting from insectary plants in the order Brassicales target insects pests ranging from specialists, such as P. xylostella, to highly polyfagous, such as the stink bugs Euschistus conspersus Uhler and Thyanta pallidovirens Stål (Hemiptera: Pentatomidae). In the order Brassicales, the three most common trap crops are Indian mustard, Brassica juncea (L.) Czern, Chinese cabbage, Brassica rapa L., and yellow rocket, Barbarea vulgaris R. Br., while the three most common insectary plants are sweet alyssum, Lobularia maritima (L.) Desv., white mustard, Sinapis alba L, and B. vulgaris. Except for Tropaeolum majus L. (Tropaeolaceae) and Capparis decidua (Forssk.) Edgew. (Capparaceae), the tested trap crops and insectary plants in the order Brassicales belong to the family Brassicaceae.
Reading and Deafness: Eye Tracking in Deaf Readers with Different Linguistic Background
Authors: Tomasuolo Elena , Roccaforte Maria , Di Fabio Andrea 
Published: October 2018

Abstract
The aim of this study was to investigate, using an eye-tracking tool, the processes behind the exploration of written texts performed by deaf people with different language skills and different educational backgrounds. Our sample comprised 36 deaf participants (12 of whom use Italian sign language most of the time, 12 who use Italian only, and 12 who can use both languages) and 12 hearing participants who could not understand any sign language. This research shows how in respect of oculomotor movements the discriminant variable is linked to the different educational backgrounds and the reading habits of participants.
Deep Recurrent Attention Models for Histopathological Image Analysis
Authors: Momeni Alexandre , Thibault Marc , Gevaert Olivier 
Published: October 2018

AbstractHistopathology defines the gold standard in oncology. Automatic analysis of pathology images could thus have a significant impact on diagnoses, prognoses and treatment decisions for cancer patients. Recently, convolutional neural networks (CNNs) have shown strong performance in computational histopathology tasks. However, given it remains intractable to process pathology slides in their entirety, CNNs have traditionally performed inference on small individual patches extracted from the image. This often requires a significant amount of computation and can result in ignoring potentially relevant spatial and contextual information. Being able to process larger input patches and locating discriminatory regions more efficiently could help improve both computational and task specific performance. Inspired by the recent success of Deep Recurrent Attention Models (DRAMs) in image recognition tasks, we propose a novel attention-based architecture for classification in histopathology. Similar to CNNs, DRAMs have a degree of translation invariance built-in, but the amount of computation performed can be controlled independently from the input image size. The model is a deep recurrent neural network trained with reinforcement learning to attend to the most relevant areas of large input patches. We evaluate our model on histological and molecular subtype classification tasks for the glioma cohorts of The Cancer Genome Atlas (TCGA). Our results suggest that the DRAM has comparable performance to state-of-the-art CNNs despite only processing a select number of patches.