bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluoroscopy-Assisted Transnasal Onyx Occlusion of the Eustachian Tube for Lateral Skull Base Cerebrospinal Fluid Leak Repair
Authors: Patel Neil , Carlson Matthew 
Published: February 2018

Objectives To describe transnasal Eustachian tube (ET) occlusion with a liquid embolic solution for lateral skull base cerebrospinal fluid (CSF) leaks.
Design A lateral skull base CSF fistula model was developed by the authors using fresh cadaveric heads. Using a transtympanic needle, regulated pressurized pigmented saline was continuously instilled into the middle ear space and visualized endoscopically in the nasopharynx. An angioembolization catheter was then placed through the cartilaginous ET orifice just medial to the bony ET. Under endoscopic and fluoroscopic guidance, a column of liquid embolic agent was deployed into the bony ET segment up to the middle ear space.
Setting Tertiary care academic center.
Participants Cadaveric specimens.
Main Outcome Measures Cessation of CSF flow after occlusion at supraphysiologic pressures.
Results In two cadavers, a CSF fistula model was developed and endoscopic visualization of irrigant flow into the nasopharynx was confirmed. Fluoroscopy provided adequate anatomic views of the ET and middle ear, in addition to dynamic views of embolization. Cessation of flow after occlusion was successfully achieved with pressures up to 25 mm Hg, which exceeds normal physiological intracranial pressure.
Conclusion Eustachian tube occlusion with a liquid embolic solution is feasible in a novel cadaveric CSF leak model. In the future, this relatively short, straightforward procedure may become an outpatient alternative to manage intermittent or low-flow CSF fistulae following lateral skull base surgery.
Etablierung eines präoperativen Anämiemanagements
Authors: Wolf Katrin 
Published: February 2018

ZusammenfassungRund 30 % aller Patienten leiden an einer präoperativen Anämie, die einen relevanten Risikofaktor für
erforderliche Transfusionen, verlängerte Hospitalisierung, gesteigerte Morbidität und Sterblichkeit darstellt.
Die Mortalität während des Krankenhausaufenthalts kann bei Patienten mit mittlerer präoperativer Anämie um das
Doppelte erhöht sein. Zudem sind intensivpflichtige Zeit und Krankenhausverweildauer deutlich länger. Die
Etablierung eines präoperativen Anämiemanagements im Rahmen des Patient Blood Management ist daher eine
entscheidende Säule zur Verbesserung des Behandlungsergebnisses und der Patientensicherheit und kann
gleichzeitig die Kosten für das Gesundheitswesen signifikant reduzieren.
Skalenübergreifende Auswertung des Fragebogens zur Erfassung des stimmlichen Selbstkonzepts (FESS)
Authors: Nusseck Manfred , Richter Bernhard , Echternach Matthias , Spahn Claudia 
Published: February 2018

Zusammenfassung
Hintergrund Der Fragebogen zur Erfassung des stimmlichen Selbstkonzepts (FESS) bildet in drei Skalen das persönliche Erleben der eigenen Stimme ab. Dabei
werden die Beziehung zur eigenen Stimme, die Bewusstheit im Umgang mit der Stimme und der Zusammenhang zwischen Stimme und Emotion bestimmt. Für die Auswertung
des Fragebogens fehlte bisher eine skalenübergreifende Betrachtungsweise, um eine vereinfachte Interpretation der Ergebnisse zu ermöglichen.
Material und Methoden Der FESS Fragebogen wurde bei 536 Lehrkräften eingesetzt und mittels einer Diskriminanz analyse auf gemeinsame Ausprägungsmerkmale
in den Skalen untersucht. Für eine differenzierte Betrachtung von Zusammenhängen mit Stimmgesundheit, psychischer und körperlicher Gesundheit wurden ebenfalls
der Voice Handicap Index (VHI), der Fragebogen zum arbeitsbezogenen Verhaltens- und Erlebensmuster (AVEM) und der Fragebogen zur gesundheitsbezogenen
Lebensqualität (SF-12) herangezogen.
Ergebnisse Die Analyse ergab vier verschiedene Gruppen des stimmlichen Selbstkonzepts: die Gruppe 1) mit stimmlich und psychisch gesunden Werten, die
Gruppe 2) mit einem eher wenig ausgeprägtem stimmlichen Selbstkonzept und durchschnittlicher psychischer Gesundheit, die Gruppe 3) mit einer hohen Bewusstheit
im Umgang mit der Stimme und durchschnittlicher psychischer Gesundheit und die Gruppe 4) mit hohen stimmlichen und psychischen Belastungen.
Schlussfolgerung Die Ergebnisse zeigen, dass für eine Gesamtauswertung des Fragebogens zur Erfassung des stimmlichen Selbstkonzepts eine gemeinsame
Betrachtung aller drei Skalen in Betracht gezogen werden kann. Die dargestellten Gruppen stellen dafür eine geeignete Herangehensweise zur Unterstützung in der
Diagnostik zur Verfügung.
Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals
Authors: Lee Kyoung Hwan , Sulbarán Guidenn , Yang Shixin , Mun Ji Young , Alamo Lorenzo , Pinto Antonio , Sato Osamu , Ikebe Mitsuo , Liu Xiong , Korn Edward D. , Sarsoza Floyd , Bernstein Sanford I. , Padrón Raúl , Craig Roger 
Published: February 2018

Significance
All animals have the ability to move. Myosin II is the motor protein that generates this movement by powering muscular contraction; it also drives motility in nonmuscle cells. In relaxed muscle and in quiescent nonmuscle cells, myosin II is switched off by intramolecular interactions between its heads that inhibit its activity. This interacting-heads motif (IHM) is a fundamental contributor to contractile regulation. Given its importance in cell contractility, we wanted to determine when the IHM first evolved. Using electron microscopy, image averaging, and sequence analysis of myosin II from primitive organisms, we show that the IHM has existed since the earliest animals and before. This ancient origin highlights the central role of the IHM in regulating myosin II function.
Répondre présent/absent
Authors: Lauwers Peter 
Published: February 2018

Résumé
This paper offers a diachronic analysis of a pair of subject complement constructions (répondre présent/absent:
litt. ‘to answer “present”/“absent”) originating from quotative expressions. It shows how they lexicalized into fixed expressions
denoting a routinized “delocutive” (Benveniste) procedure and how they finally got reanalyzed into a subject complement
construction with an internalized projective and proactive meaning (“to act as expected”). The latter appears to be the result of
the pragmatic strengthening of conversational implicatures related to the speech act. Further, it is argued that the remarkably
similar evolution of répondre absent is due to analogization. Finally, the discussion of potential further host
class expansion leads to a provisional answer to the question of whether or not these developments could be the symptoms of the
constructionalization of a new copular verb.
Solvable spectral problems from 2d CFT and

N

= 2 gauge theories
Authors: Piątek M R , Pietrykowski A R 
Published: February 2018

Abstract
The so-called 2d/4d correspondences connect two-dimensional conformal field theory (2d CFT),

N

= 2 supersymmetric gauge theories and quantum integrable systems. The latter in the simplest case of the SU(2) gauge group are nothing but the quantum-mechanical systems. In the present article we summarize our recent results and list open problems concerning an application of the aforementioned dualities in the studies of spectral problems for some Schrödinger operators with Mathieu–type periodic, periodic PT–symmetric and (Heun’s) elliptic potentials.
Where to search top-K biomedical ontologies?
Authors: Oliveira Daniela , Butt Anila Sahar , Haller Armin , Rebholz-Schuhmann Dietrich , Sahay Ratnesh 
Published: February 2018

AbstractMotivationSearching for precise terms and terminological definitions in the biomedical data space is problematic, as researchers find overlapping, closely related and even equivalent concepts in a single or multiple ontologies. Search engines that retrieve ontological resources often suggest an extensive list of search results for a given input term, which leads to the tedious task of selecting the best-fit ontological resource (class or property) for the input term and reduces user confidence in the retrieval engines. A systematic evaluation of these search engines is necessary to understand their strengths and weaknesses in different search requirements.ResultWe have implemented seven comparable Information Retrieval ranking algorithms to search through ontologies and compared them against four search engines for ontologies. Free-text queries have been performed, the outcomes have been judged by experts and the ranking algorithms and search engines have been evaluated against the expert-based ground truth (GT). In addition, we propose a probabilistic GT that is developed automatically to provide deeper insights and confidence to the expert-based GT as well as evaluating a broader range of search queries.ConclusionThe main outcome of this work is the identification of key search factors for biomedical ontologies together with search requirements and a set of recommendations that will help biomedical experts and ontology engineers to select the best-suited retrieval mechanism in their search scenarios. We expect that this evaluation will allow researchers and practitioners to apply the current search techniques more reliably and that it will help them to select the right solution for their daily work.AvailabilityThe source code (of seven ranking algorithms), ground truths and experimental results are available at https://github.com/danielapoliveira/bioont-search-benchmark
LS-align: an atom-level, flexible ligand structural alignment algorithm for high-throughput virtual screening
Authors: Hu Jun , Liu Zi , Yu Dong-Jun , Zhang Yang 
Published: February 2018

Abstract

Motivation
Sequence-order independent structural comparison, also called structural alignment, of small ligand molecules is often needed for computer-aided virtual drug screening. Although many ligand structure alignment programs are proposed, most of them build the alignments based on rigid-body shape comparison which cannot provide atom-specific alignment information nor allow structural variation; both abilities are critical to efficient high-throughput virtual screening.

Results
We propose a novel ligand comparison algorithm, LS-align, to generate fast and accurate atom-level structural alignments of ligand molecules, through an iterative heuristic search of the target function that combines inter-atom distance with mass and chemical bond comparisons. LS-align contains two modules of Rigid-LS-align and Flexi-LS-align, designed for rigid-body and flexible alignments, respectively, where a ligand-size independent, statistics-based scoring function is developed to evaluate the similarity of ligand molecules relative to random ligand pairs. Large-scale benchmark tests are performed on prioritizing chemical ligands of 102 protein targets involving 1 415 871 candidate compounds from the DUD-E (Database of Useful Decoys: Enhanced) database, where LS-align achieves an average enrichment factor (EF) of 22.0 at the 1% cutoff and the AUC score of 0.75, which are significantly higher than other state-of-the-art methods. Detailed data analyses show that the advanced performance is mainly attributed to the design of the target function that combines structural and chemical information to enhance the sensitivity of recognizing subtle difference of ligand molecules and the introduces of structural flexibility that help capture the conformational changes induced by the ligand–receptor binding interactions. These data demonstrate a new avenue to improve the virtual screening efficiency through the development of sensitive ligand structural alignments.

Availability and implementation
http://zhanglab.ccmb.med.umich.edu/LS-align/

Supplementary information
Supplementary data are available at Bioinformatics online.
Unpalatable Truths: Food and Drink as Medicine in Colonial British India
Authors: Goodman Sam 
Published: February 2018

Abstract
This article considers the significance of eating and drinking within a series of diaries and journals produced in British colonial India during the Indian Rebellion of 1857. The discussion of food and drink in this context was not simply a means to add color or compelling detail to these accounts, but was instead a vital ingredient of the authors’ understanding of health and medical treatment. These texts suggest a broader colonial medical understanding of the importance of regulating diet to maintain physical health. Concern with food, and the lack thereof, was understandably a key element in diaries, and in the eyewitness accounts kept by British soldiers, doctors, and civilians during the rebellion. At a narrative level, mention of food also functioned as a trope serving to increase dramatic tension and to capture an imagery of fortitude. In references to drink, by contrast, these sources reveal a conflict between professional and lay opinions regarding the use of alcohol as part of medical treatment. The accounts show the persistent use of alcohol both for medicinal and restorative purposes, despite growing social and medical anxieties over its ill-effects on the body. Close examination of these references to food and drink reflect the quotidian habits, social composition, and the extent of professional and lay knowledge of health and medicine in colonial British India.
Incidence and Time of Onset of Osseous Pseudoprogression in Patients With Metastatic Spine Disease From Renal Cell or Prostate Carcinoma After Treatment With Stereotactic Body Radiation Therapy
Authors: Jabehdar Maralani Pejman , Winger Kathleen , Symons Sean , Machnowska Matylda , Heyn Chinthaka , Helmi Ali , Chan Aimee , Tseng Chia-Lin , Sahgal Arjun 
Published: February 2018

Abstract

BACKGROUND
Tumor osseous pseudoprogression (PP), defined as an imaging-based transient increase in tumor size following treatment, was recently described in patients with spinal metastases following stereotactic body radiation therapy. Distinguishing PP from true tumor progression is critical.

OBJECTIVE
To describe the incidence, time of onset, and time range of PP following stereotactic body radiation therapy in patients treated for spinal metastases from either prostate cancer (PC) or renal cell carcinoma (RCC), and associated predictive factors.

METHODS
A retrospective study was conducted on our institution's cancer database from 2009 to 2015. Selection was based on single level, no prior radiation or surgery, ≥2 follow-up spine magnetic resonance imaging (MRI), and metastases arising from either PC or RCC. Gross tumor volume was contoured on pre- and up to 5 posttreatment MRIs. Patients were sorted into groups depending on gross tumor volume response: PP, non-PP, or progressive disease. Clinical and dosimetric variables were compared using either Fisher's exact test or Kruskal–Wallis analyses.

RESULTS
Forty-three spinal segments from 31 patients were analyzed. RCC and PC patients showed similar incidence of PP (∼37%). Whether the primary was lytic or sclerotic was a significant predictive factor with more PP in the lytic group (P = .0208). There was a trend of earlier PP onset in RCC (within 6-18 mo) as compared to PC; however, PC segments showed more time-confined presentation of PP (9-12 mo).

CONCLUSION
There was a higher incidence of PP in lytic compared to sclerotic primary tumor type. PP in spinal metastatic sites may have variable presentations depending on the primary cancer.
Improving Physical Therapy Pain Care, Quality, and Cost Through Effectiveness-Implementation Research
Authors: Joyce Chris , Schneider Michael , Stevans Joel M , Beneciuk Jason M 
Published: February 2018

Abstract
The variability and delay in utilizing evidence in clinical practice are barriers to improving care, quality, and cost in health care, as charged by the “triple aim” framework. Scientific research provides an avenue not only to further the field of pain research, but also to study and change the patterns and processes that drive systemic and individual clinical practices. Implementation science is an emerging field that can be integrated with more traditional effectiveness research to accomplish a combination of aims within the same study. This type of concurrent study of effectiveness and implementation is known as a hybrid design and can be used to improve behavioral or operational practice patterns as well as to collect evidence of clinical effectiveness. Recently, the National Pain Strategy put forth recommendations to improve the care of patients with pain through research and practice. Hybrid designs align well with recent efforts that emphasize value-based, patient-centered health care evolving and described in the National Pain Strategy. The purposes of this perspective are to describe implementation science and hybrid studies and to put forth opportunities to utilize this research to advance the care of patients with pain in the United States.
T-Lymphoblastic Leukemia/Lymphoma With Annular Skin Rash and Epidermotropism
Authors: Mansoori Parisa , Taheri Arash , O'Neill Stacey S. , Sangueza Omar P. 
Published: February 2018

Abstract:
Leukemia cutis is uncommon in patients with acute lymphoblastic leukemia. It typically presents with dermal papules or subcutaneous nodules, with no epidermal or upper papillary dermal involvement on histopathology. We present an unusual clinical presentation of leukemia cutis, with annular plaques and epidermotropism.
Out of the Closet, Into the Clinic: Opportunities for Expanding Men Who Have Sex With Men–Competent Services in China
Authors: Watson Julia , Tang Weiming , Pan Stephen , Wu Dan , Zhao Peipei , Cao Bolin , Liu Chuncheng , Bien Cedric , Huang Wenting , Luo Zhenzhou , Tucker Joseph D. 
Published: February 2018

Background
Despite the high human immunodeficiency virus (HIV) burden among men who have sex with men (MSM), there is little research on health services provided to MSM in China and other low- and middle-income countries. Discrimination and inadequate services may discourage MSM from seeking health care services. This study examined essential services provided to MSM and health care discrimination among MSM in China.

Methods
A nationwide cross-sectional online survey was conducted among MSM who saw a physician in the last 24 months in China. The survey included items on sociodemographic information, HIV testing, experiences from the last physician encounter, and history of perceived health care discrimination. We defined MSM-competent physicians as physicians who asked their patient about having sex with other men, asked about anal sex, and either asked about or recommended HIV testing at the most recent visit.

Results
Among the 503 participants, 35.0% (176/503) saw an MSM-competent physician. In multivariate analyses, respondents who saw an MSM-competent physician were more likely to be younger (adjusted odds ratio [AOR], 0.87; 95% confidence interval [CI], 0.81–0.94), have a primary care physician (AOR, 3.24; 95% CI, 1.85–5.67), and be living with HIV (AOR, 2.01; 95% CI, 1.13–3.56). 61.2% (308/503) of MSM had ever experienced health care discrimination.

Conclusions
Our data suggest that there is variability in the extent to which physicians are meeting the needs of MSM in China. There is an urgent need to evaluate and expand MSM-competent services in China.
Fat Grafting for Facial Rejuvenation and Contouring
Authors: Pu Lee L. Q. 
Published: February 2018

Abstract
The clinical outcome after fat grafting for facial rejuvenation and contouring can be less optimal because lack of standardized techniques is performed by the surgeon for the procedure. In this review, the author has tried to provide a rationalized approach to fat grafting for facial rejuvenation and contouring. The preferred donor sites include low abdomen and inner thigh especially in younger patients. Fat grafts should be harvested with low negative pressure via syringe liposuction technique to ensure the integrity as well as the optimal level of cellular function. Fat grafts should be processed with proper centrifugation that can reliably produce purified fat and concentrated growth factors and adipose-derived stem cells, all of which are beneficial to improve graft survival. Fat grafts should be placed after certain principles with gentle injection of small amount during the withdraw phase of each pass in multiple tissue planes and levels with multiple passes to ensure maximal contact of graft with vascularized tissue in the recipient site. The approach described in this review is supported by the most recent scientific studies and thus can likely provide a more predictable long-lasting result if performed properly.
The focused abdominal sonography for trauma examination can reliably identify patients with significant intra-abdominal hemorrhage in life-threatening pelvic fractures
Authors: Christian Nicole Townsend , Burlew Clay Cothren , Moore Ernest E. , Geddes Andrea E. , Wagenaar Amy E. , Fox Charles J. , Pieracci Fredric M. 
Published: February 2018

BACKGROUNDThe focused abdominal sonography for trauma (FAST) examination has been reported to be unreliable in pelvic fracture patients. Additionally, given the advent of new therapeutic interventions, such as resuscitative endovascular balloon occlusion of the aorta (REBOA), rapid identification of intra-abdominal hemorrhage compared with Zone III hemorrhage may guide different therapeutic strategies. Wehypothesizedthat FAST is reliable for detecting clinically significant intra-abdominal hemorrhage in the face of complex pelvic fractures.METHODSOur pelvic fracture database of all hemodynamically unstable patients requiring intervention from January 1, 2005, to July 1, 2015, was reviewed. The FAST examination was compared with operative and computed tomography (CT) scan findings. Confirmatory evaluation for FAST(−) patients was considered positive if therapeutic intervention was required.RESULTSDuring the study period, 81 patients in refractory shock with FAST imaging in our emergency department (ED) underwent pelvic packing. Mean age was 45 ± 2 years and Injury Severity Score was 50 ± 1.5. The FAST examination was negative in 53 patients; 52 patients did not require operative intervention for abdominal bleeding while one patient required splenectomy. The FAST examination was positive in 28 patients; 26 had findings confirmed by CT or laparotomy while two patients did not have intra-abdominal hemorrhage on further evaluation. The sensitivity and specificity for FAST in this population was 96% and 96%, respectively, positive predictive value was 93%, and negative predictive value was 98%. The false-negative and -positive rates for FAST were 2% and 7%.CONCLUSIONFocused abdominal sonography for trauma examination reliably identifies clinically significant hemoperitoneum in life-threatening, pelvic fracture related hemorrhage. The incidence of a false-negative FAST in this unstable pelvic fracture population was 2%. FAST results may be used when determining the role of REBOA in these multisystem trauma patients and requires further study. REBOA placement should be considered in hemodynamically unstable pelvic fracture patients who are FAST(−), while laparotomy should be used in FAST(+) patients.LEVEL OF EVIDENCETherapeutic, level IV.