bluuebunny/crossref_metadata_2025_split huggingface dataset:
KESIAPAN SUAMI SEBAGAI PENDAMPING PERSALINAN DI PUSKESMAS PLERET KABUPATEN BANTUL YOGYAKARTA
Authors: Eka Noviana Rizky , Puspitasari Dian 
Published: March 2018

Background: On the third trimester of pregnancy, stressors of mother, her husband and family will increasedue to their physical and emotional preparations. Social support is very important for mother prior to labor. Husband’s companion in delivery process is perceived very significant. World Health Organization (WHO) suggested that the companion in delivery processis a mother’s choice. In Indonesia 68% delivery are not accompanied by husband. A companion, in particular a significant personduring the process of delivery can shortenthe delivery period, decrease the pain level, lessen the laceration and promote APGAR’s score.
Aim: To explore husbands’ readiness as companion in delivery process at Puskesmas Pleret, Bantulregency.
Method: This research was a descriptivequantitative research. Samples in the research were chosen with a quota sampling method, consisted of 37 husbands of trimester III mothers and fit in with inclusion and exclusion criteria. Data were collected with a closed questionnaire and were analyzed with univariate analysis.
Result: The majority of respondents were ready as companions in stage I, stage II, stage III and stage IV of the delivery process (86.5%, 70.3%, 91.9%, and 83.8%, respectively).
Conclusion: The majority of husbands wereready to accompanythe delivery process at Puskesmas Pleret, Bantul regency(70,3% respondents).
Keywords: readiness, companion of delivery.
FILM PENDEK ALAT PENGKAJIAN KESEHATAN KELUARGA KHON KAEN UNIVERSITY
Authors: Suwarno Suwarno , Jongudomkarn DaruneeJongudomkarn 
Published: March 2018

Background:Family health care in family nursing is focused on a holistic health care view. A holistic health carewill be achieved if the family health nursing care is properly executed. The continuing education is appropriate to increase the family health assessment application and understanding. It consists of training programs, which might take advantage of a video as a learning media.
Objective:The objective of the study was to produce the KKU FHA tool short movie based on the 3 phases; pre-production, production and post-production.
Methods:Five nursing educators reviewed the video and evaluateit with a form in a Likert scale.
Result: This video was in MOV format, sized1.12 GB, the picture size was 1280x720, codec H.264, AAC,
length of time was 16.53 minutes and could be opened in smartphone andcomputer. The mean score of the evaluation form was 3.6 for the quality of sound and 4.8 for the benefit of the video. The total mean score was 45.8 out of55.
Conclusion:The KKU FHA tool short video was appropriate and could be implemented ina try-out or a training program, and couldalsobe developed and improvedto achieve the best quality of sound and picture.
Keywords: family health assessment, KKU FHA Tool, training, short movie
ONSET PENGELUARAN KOLOSTRUM PADA IBU POST PARTUM DENGAN PERSALINAN NORMALVLEBIH CEPAT DARIPADAVPERSALINAN SECTIO CAESARIA
Authors: Kause Maria NSW , Trisetiyaningsih Yanita , Sukmawati Anastasia Suci 
Published: March 2018

Background : Lactation onset is a term of multiplying breast milk until the release of breast milk for the first time or mothers’ perception on when her breast milk will be released which is marked by a bit hard breast, inflammed, and full of breast milk or the release of colostrum. Colostrum is the first liquid secreted by breast milk gland since the first day until the fourth day. One of factors which influences lactation onset is labor method and early breastfeeding initiation (IMD). Mothers who undergo sectio caesaria surgery will feel painful and the effect of prolonged usage of anesthesia so that early breastfeeding initiation cannot be implemented compared to mothers with normal labors and the usage of anesthesia which slows down lactation onset.
Objective : To find out the difference between colostrum releasing onset in post partum mothers with normal labors and sectio caesaria in Panembahan Senopati General Hospital, Bantul. Method : The design of this study was cross sectional. The number of samples were 80 respondents selected with purposive sampling technique. Study instrument was observational sheets. Data analysis applied Mann-Whitney test.
Result : The majority of respondents who had normal labors and sectio caesaria experienced different colostrum onset. In normal labors, the time of colostrum release was 1 day. In sectio caesaria labors, the time of colostrum release was 2 days. The average duration of post partum mothers with normal labors was 13,6 hours and post partum mothers with sectio caesaria was 22,6 hours. The result of Mann-Whitney test was that there was a difference between colostrum release onset of post partum mothers with normal labors and sectio caesaria with p value 0,001 (p<0,05) which implied that Ho was rejected.
Conclusion : Normal labors and sectio caesaria labors had different colostrum onset.

Keyword : Colostrum, Normal labors, Sectio Caesaria labors.
Effectiveness of Early Treatment with Steroids in Outcome of Sudden Sensorineural Hearing Loss. A study from Western Nepal
Authors: Rai Shiwani , Koirala Krishna , Sherpa Pema 
Published: March 2018

Objective: To study the effect of early versus delayed treatment of Sudden Sensorineural Hearing Loss (SSNHL) in hearing outcome.Material and Methods: A retrospective study of patients with SSNHL was done from October 2012 to October 2014 to study the effect of early versus late treatment in hearing outcome in ENT department of Manipal Teaching Hospital, Pokhara, Nepal. Patients receiving treatment within 3 days of onset of symptoms were placed in early treatment group (ET) and those receiving treatment after 3 but within 7 days were placed in late treatment group (LT). Hearing outcome was assessed using pure tone average (PTA) and was carried out at presentation and then at 3,7,14 and 30 days after treatment. A mixed between and within- subject design ANOVA test was used to analyze the results using SPSS 20.0.Results: There were 29 patients in ET group and 25 patients in LT group. Mean age of the study population was 36.37 years (SD=7.868). The M:F ratio was 0.39:1. There was a significant interaction between time and treatment group, Wilk’s Lambda= 0.382, F (1.52, 79.196) = 19.83, p <0.001, partial eta squared =0.541. There was a substantial main effect of time, F (1.52, 79.196)= 180.36, p <0.001, partial eta squared = 0.776 suggesting significant improvement of hearing levels with time. The main effect comparing early and late treatment groups was also significant, F (1,52)= 5.799, p=0.02, partial eta squared = 0.100 suggesting significant difference in hearing levels in between the two treatment groups.Conclusion: Onset of treatment after the initial symptom significantly affects the outcome of hearing improvement in SSNHL. There are higher chances of improving if treatment is started within 3 days of onset of symptoms.
No Relationship of Anti-Androgens to Alzheimer’s Disease or Cognitive Disorder in the MedWatch Database
Authors: Lehrer Steven , Rheinstein Peter H. , Rosenzweig Kenneth E. 
Published: March 2018

Background: Two large studies suggest that risk is not increased. But other studies have found increased risk of Alzheimer’s disease and impaired cognition. Objective: To determine whether androgen deprivation therapy increases the risk of impaired cognition or Alzheimer’s disease in men with prostate cancer. Methods: We used data from MedWatch, the Food and Drug Administration (FDA) Safety Information and Adverse Event Reporting Program. Machine-readable data from MedWatch, including adverse drug reaction reports from manufacturers, are part of a public database. We used the online tool OpenVigil 2.1 to query the database. OpenVigil calculates proportional reporting ratios (PRRs) from adverse drug reaction reports to determine whether the combination of drug and adverse event are related. For example, PRR = 2 indicates that the adverse reaction is two times more frequent in users of the drug than in the general population. Results: We analyzed adverse event reporting data for these androgen-deprivation drugs: The luteinizing hormone releasing hormone (LHRH) agonists leuprolide, goserelin triptorelin, histrelin; the anti-androgens flutamide, nilutamide, enzalutamide, and bicalutamide; the LHRH antagonist degarelix; the CYP17 inhibitor abiraterone; the anti-fungal ketoconazole, which is also an anti-androgen administered to men with advanced prostate cancer. Conclusion: Our analysis of FDA MedWatch adverse event data reports does not support the idea that androgen deprivation therapy per se is associated with Alzheimer’s disease or cognitive dysfunction. Perhaps the prostate cancer itself, or the stress it imposes on the man who has it, may be detrimental to mood and intellect, increasing susceptibility to Alzheimer’s disease and cognitive disorder.
How Residents Learn From Patient Feedback: A Multi-Institutional Qualitative Study of Pediatrics Residents' Perspectives
Authors: Bogetz Alyssa L. , Orlov Nicola , Blankenburg Rebecca , Bhavaraju Vasudha , McQueen Alisa , Rassbach Caroline 
Published: March 2018

ABSTRACT

Background
Residents may view feedback from patients and their families with greater skepticism than feedback from supervisors and peers. While discussing patient and family feedback with faculty may improve residents' acceptance of feedback and learning, specific strategies have not been identified.

Objective
We explored pediatrics residents' perspectives of patient feedback and identified strategies that promote residents' reflection on and learning from feedback.

Methods
In this multi-institutional, qualitative study conducted in June and July 2016, we conducted focus groups with a purposive sample of pediatrics residents after their participation in a randomized controlled trial in which they received written patient feedback and either discussed it with faculty or reviewed it independently. Focus group transcripts were audiorecorded, transcribed, and analyzed for themes using the constant comparative approach associated with grounded theory.

Results
Thirty-six of 92 (39%) residents participated in 7 focus groups. Four themes emerged: (1) residents valued patient feedback but felt it may lack the specificity they desire; (2) discussing feedback with a trusted faculty member was helpful for self-reflection; (3) residents identified 5 strategies faculty used to facilitate their openness to and acceptance of patient feedback (eg, help resident overcome emotional responses to feedback and situate feedback in the context of lifelong learning); and (4) residents' perceptions of feedback credibility improved when faculty observed patient encounters and solicited feedback on the resident's behalf prior to discussions.

Conclusions
Discussing patient feedback with faculty provided important scaffolding to enhance residents' openness to and reflection on patient feedback.
Voltammetric determination of cholecalciferol at glassy carbon electrode performed in water ethanol mixture
Authors: Nallbani Arlinda , Holubová Julie , Sýs Milan , Arbneshi Tahir , Vytřas Karel 
Published: March 2018

To confirm or disprove previous hypotheses, cyclic voltammetry of 0.5 mM cholecalciferol (vitamin D3) at glassy carbon electrode (GCE) and platinum disk electrode (PtE) in pure acetonitrile and water‑ethanol mixture at 50 mV·s‑1 has been used to investigate the oxidation mechanism. The oxidation occurs in two one-electrone steps. According to calculation of the highest electron density in cholecalciferol molecule which is evidently delocalized over carbon atoms of the three conjugated double bonds (C19, C10, C5-C8) points to part of the molecule involved in oxidation processes. An oxidation peak (at +0.925 V vs. Ag/AgCl) was used to develop direct voltammetric method based on differential pulse voltammetry for the vitamin D3 determination at GCE performed in 40% ethanol containing 0.1 M LiClO4. Under optimization of analytical procedure, it was found that a composition of the supporting electrolyte used significantly affects a current response of oxidation peak obtained. Satisfactory sensitivity was achieved in the 1:1 water‑ethanol mixture containing 0.05 M lithium perchlorate as as supporting electrolyte. The linear range for vitamin D3 determination was2.4 × 10-6 - 3.5 × 10-4 M with the detection limit of 8.0 × 10-7 M. This work demonstrates a fact that the GCE is suitable electroanalytical device for analysis of various food supplements and medicaments.
Evaluation of selected quality parameters of reduced salt frankfurters
Authors: Jůzl Miroslav , Saláková Alena , Müllerová Martina , Kozohorská Klára 
Published: March 2018

Higher salt content in foods brings health risks associated with hypertension and leads to an increased risk of strokes and fatal vascular diseases. For this study, a frankfurter was chosen as a frequently consumed meat product. In repetitions, four groups of products were produced with different salt contents (2.0% and 1.4%) and the kind of meat used (CPF - Control Pork Frankfurters, RPF - Reduced salt Pork Frankfurters, CBF - Control Beef Frankfurters, RBF - Reduced salt Beef Frankfurters). Basic chemical parameters (dry matter, fat and salt content), colour parameters (CIE L*, a* and b*) and basic sensory analysis were performed before (UT - untreated) and after heat treatment (HT - heat treated). The lower salt content and the type of meat used have a significant effect (p ˂0.05) on the colour of the products. In almost all parameters frankfurters with pork meat scored better than frankfurters with beef meat. The lower salt content and the type of meat used proved to have affected the colour of the products. After heat treatment there were found statistical significant differences in saltiness between control and salt reduced group (UT, p = 0.0098; HT p = 0.0001). Sensory results were better with pork and higher salt. A more key role than salt content in frankfurters is played by the type of meat. Debrecener´s frankfurter was selected for this study, and its formula can serve as a good example for the manufacturers that there is no need to worry about one third salt mixture reduction in the recipe on frankfurters sensory analysis.
Internal control in accounting research: A review
Authors: Chalmers Keryn , Hay David , Khlif Hichem 
Published: March 2018

In 2001, the US moved to regulate internal control reporting by management and auditors. While some jurisdictions have followed the lead of the US, many others have not. An important question, therefore, is the relevance of internal control to stakeholders. The more specific issue of the benefits of US-style regulation of internal control reporting is also topical. We review studies on the determinants of internal control quality and its economic consequences for stakeholders including investors, creditors, managers, auditors and financial analysts. We extend previous reviews by focusing on US studies published since 2013 as well as all non-US studies investigating IC quality including countries regulating IC disclosure as well as unregulated settings and both developed and developing economies. In doing so, we identify research questions where evidence remains mixed and new directions in which there are research opportunities.
Three main insights arise from our analysis. First, evidence on the economic consequences of internal control quality suggests that the quality of internal control can have a significant effect on decision making by users of financial information. Second, the results of research on the empirical association between ownership structure, certain board characteristics and internal control quality is generally mixed. Empirical evidence concerning the association between audit committee characteristics and internal control quality generally supports a positive and significant association. Finally, while studies in non-US jurisdictions are increasing, opportunities remain to explore the determinants and consequences of internal control in other jurisdictions. Our review provides evidence for policy makers of whether there are benefits from requiring management and auditors to report on internal control over financial reporting.
The personalized Alzheimer's disease cortical thickness index predicts likely pathology and clinical progression in mild cognitive impairment
Authors: Racine Annie M. , Brickhouse Michael , Wolk David A. , Dickerson Bradford C. ,   Alzheimer's Disease Neuroimaging Initiative
Published: March 2018

AbstractIntroductionAn Alzheimer's disease (AD) biomarker adjusted for age‐related brain changes should improve specificity for AD‐related pathological burden.MethodsWe calculated a brain‐age‐adjusted “personalized AD cortical thickness index” (pADi) in mild cognitive impairment patients from the Alzheimer's Disease Neuroimaging Initiative. We performed receiver operating characteristic analysis for discrimination between patients with and without cerebrospinal fluid evidence of AD and logistic regression in an independent sample to determine if a dichotomized pADi predicted conversion to AD dementia.ResultsReceiver operating characteristic area under the curve was 0.69 and 0.72 in the two samples. Three empirical methods identified the same cut‐point for pADi in the discovery sample. In the validation sample, 83% of pADi+ mild cognitive impairment patients were cerebrospinal fluid AD biomarker positive. pADi+ mild cognitive impairment patients (n = 63, 38%) were more likely to progress to AD dementia after 1 (odds ratio = 2.9) and 3 (odds ratio = 2.6) years.DiscussionThe pADi is a personalized, magnetic resonance imaging–derived AD biomarker that predicts progression to dementia.
Intralymphatic Immunotherapy With Autologous Semen in a Korean Man With Post-Orgasmic Illness Syndrome
Authors: Kim Tae Beom , Shim Young Sup , Lee Sang Min , Son Eun Suk , Shim Jung Woo , Lee Sang Pyo 
Published: March 2018

Abstract
Post-orgasmic illness syndrome (POIS) is a very rare disease characterized by local allergic symptoms and transient flu-like illness that nearly always occur after masturbation, coitus, or spontaneous ejaculation and last for 2 to 7 days. In a previous case report, 2 patients with POIS received hyposensitization therapy composed of multiple subcutaneous injections of autologous semen that resulted in a gradual decrease of symptoms. However, this procedure requires patients to endure pain and discomfort during frequent subcutaneous injections and preceding masturbations to obtain the autologous semen used for therapy. Recent studies have suggested that intralymphatic immunotherapy is a promising new method of allergen-specific immunotherapy against allergic diseases, showing a faster onset and longer duration of therapeutic effects after only several intralymphatic injections. We report on a case of a Korean man with POIS who received intralymphatic immunotherapy that alleviated POIS-related symptoms and in whom the existence of semen-specific immunoglobulin E was confirmed using immunoglobulin E immunoblotting and enzyme-linked immunosorbent assay.
Elevated DNA methylation across a 48‐kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology
Authors: Smith Rebecca G. , Hannon Eilis , De Jager Philip L. , Chibnik Lori , Lott Simon J. , Condliffe Daniel , Smith Adam R. , Haroutunian Vahram , Troakes Claire , Al‐Sarraj Safa , Bennett David A. , Powell John , Lovestone Simon , Schalkwyk Leonard , Mill Jonathan , Lunnon Katie 
Published: March 2018

AbstractIntroductionAlzheimer's disease is a neurodegenerative disorder that is hypothesized to involve epigenetic dysregulation of gene expression in the brain.MethodsWe performed an epigenome‐wide association study to identify differential DNA methylation associated with neuropathology in prefrontal cortex and superior temporal gyrus samples from 147 individuals, replicating our findings in two independent data sets (N = 117 and 740).ResultsWe identify elevated DNA methylation associated with neuropathology across a 48‐kb region spanning 208 CpG sites within the HOXA gene cluster. A meta‐analysis of the top‐ranked probe within the HOXA3 gene (cg22962123) highlighted significant hypermethylation across all three cohorts (P = 3.11 × 10−18).DiscussionWe present robust evidence for elevated DNA methylation associated with Alzheimer's disease neuropathology spanning the HOXA gene cluster on chromosome 7. These data add to the growing evidence highlighting a role for epigenetic variation in Alzheimer's disease, implicating the HOX gene family as a target for future investigation.
Multi-objective design of thickness and curvature of a bendable structure considering delamination and strength characteristics
Authors: Lee Hyunseok , Chae Han-Seok , Joo Won-Seok , Lee Jongsoo 
Published: March 2018

Abstract
The present study explores the finite element analysis and design optimization of a multi-layered bendable structure (i.e., a device of smart watch) considering delamination characteristics and materials strength conditions. The materials used for device and rubber in the smart watch are polycarbonate and thermoplastic polyurethane, respectively. Mooney-Rivlin model is employed to accommodate the hyperelastic behavior of rubber under large deformation. An evaluation of the delamination between layers and adhesive of the smart watch is conducted based on the cohesive zone model. The present study suggests the physical definitions of the vertical gap and sliding distance to describe the debonding/delamination properties in case of a bendable structure undergoing a large deformation. In the optimal design for the glass thickness, display thickness and radius of curvature, the bi-objective formal optimization is formulated to minimize both the vertical gap and sliding distance subjected to constraints on materials strength requirements of glass stress and display stress. The optimal design solutions are obtained using 2nd order polynomial based response surface models and a non-dominated sorting genetic algorithm (NSGA-II) in the context of multi-objective approximate optimization. In the optimization result, the sliding distance is improved by 25.64% with the secured stress limits compared to an initial design. The sliding distance value has been more enhanced under the contribution of the shear mode of delamination than the vertical gap under the normal mode. The study accommodates more enhanced design solutions to minimize debonding/delamination properties under strength requirements.
Highlights This work conducts the design optimization of a multi-layered bendable structure (i.e., a smart watch). The delamination and materials strength requirements are considered. The delamination between layers and adhesive is performed based on the cohesive zone model. Vertical gap and sliding distance to represent delamination properties are suggested. The sliding distance is improved by 25.64% with the secured stress limits.