bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of CT findings for prognostic prediction of spontaneous superior mesenteric artery dissection
Authors: Yoshida Rika , Yoshizako Takeshi , Maruyama Minako , Takinami Yoshikazu , Shimojo Yoshihide , Tamaki Yukihisa , Kitagaki Hajime 
Published: June 2018

Background Spontaneous superior mesenteric artery (SMA) dissection is rare cause of acute abdomen. Time-dependent change of SMA dissection has not been established. Purpose To determine Sakamoto classification (SC) type of acute and chronic SMA dissection (aSMAD and cSMAD) to predict the treatment methods and outcome. Material and Methods From April 2003 to March 2017, unenhanced and contrast-enhanced CT were used to diagnose acute symptomatic or chronic asymptomatic SMA dissection in 25 consecutive patients without aortic dissection. Correlations between SCs and treatment methods and outcomes were investigated. Results All 13 patients with aSMAD initially received conservative treatment. Initial SCs in aSMAD were type I = 1, type III = 9, and type IV = 3. Three of nine initial type III and two of three initial type IV changed to type I at follow-up. One of nine type III changed to type II at follow-up. Ohers did not change. One with initial type III required vascular repair, so the final SC was not available. Three patients required bowel resection. In cSMAD of 12 patients, the initial/final SC were type I and IV in ten and two patients, respectively, without change during follow-up. cSMAD was significantly older than aSMAD. The initial length of dissection of aSMAD was longer than in the cSMAD group. In aSMAD, the final length of dissection was significantly shorter than in the initial computed tomography scan. Conclusion Initial SC differed significantly between aSMAD and cSMAD. Initial SC types in aSMAD were type III and IV mainly, and changed during the observation period. In cSMAD, SC types were I and IV without change.
Clinical routine use of virtual monochromatic datasets based on spectral CT in patients with hypervascularized abdominal tumors - evaluation of effectiveness and efficiency
Authors: Böning Georg , Feldhaus Felix , Adelt Sebastian , Kahn Johannes , Fehrenbach Uli , Streitparth Florian 
Published: June 2018

Background Virtual monochromatic images (VMI) generated using spectral computed tomography (CT) are promising recently available tools to improve diagnostic performance in oncologic patients. Purpose To investigate if virtual monochromatic datasets are suitable for clinical routine use in patients with hypervascularized abdominal tumors. Material and Methods A total of 41 patients with hypervascularized hepatocellular carcinoma (HCC), renal cell carcinoma (RCC), or neuroendocrine tumors (NET) were enrolled in the study; 451 CT series were analyzed. In an intra-individual study design, virtual monochromatic datasets of the arterial phase of each scan were computed. Image quality was assessed objectively by determining signal-to-noise ratio (SNR) and contrast-to-noise ratios (CNR) and subjectively by using five-point Likert-scales. The volume CT dose index (CTDIvol) was taken from each radiation dose report. The increase in reading time was estimated from the increase in the number of images. Results Intra-individual comparison of the spectral mode in the arterial phase with the portal venous phase revealed no significant increase in the applied dose. SNR, CNRtumor-to-liver , and CNRtumor-to-muscle were significantly increased by lowering virtual monochromatic energy. Subjective image quality scores revealed an increase of contrast in low energy datasets, resulting in significantly higher diagnostic confidence, but an increased image noise at low energies. While diagnostic confidence improved, taking all datasets into account resulted in a significantly longer estimated reading time. Conclusion In clinical practice, the use of low energy VMI improved diagnostic confidence without a significant increase in dose. The main disadvantage is a decrease in efficiency due to longer reading times.
Using Patients and Their Caregivers Feedback to Develop ENABLE CHF-PC: An Early Palliative Care Intervention for Advanced Heart Failure
Authors: Akyar Imatullah , Dionne-Odom J. Nicholas , Bakitas Marie A. 
Published: June 2018

Objective: Models of early, community-based palliative care for individuals with New York Heart Association (NYHA) class III/IV heart failure and their families are lacking. We used the Medical Research Council process of developing complex interventions to conduct a formative evaluation study to translate an early palliative care intervention from cancer to heart failure. Method: One component of the parent formative evaluation pilot study was qualitative satisfaction interviews with 8 patient–caregiver dyad participants who completed Educate, Nurture, Advise, Before Life Ends Comprehensive Heartcare For Patient and Caregivers (ENABLE CHF-PC) intervention. The ENABLE CHF-PC consists of an in-person palliative care assessment, weekly telehealth coaching sessions, and monthly follow-up. Subsequent to completing the coaching sessions, patient and caregiver participants were interviewed to elicit their experiences with ENABLE CHF-PC. Digitally recorded interviews were transcribed and analyzed using a thematic approach. Results: Patients (n = 8) mean age was 67.3, 62.5% were female, 75% were married/living with a partner; caregivers (n = 8) mean age was 56.8, and 87.5% were female. Four themes related to experiences with ENABLE CHF-PC included “allowed me to vent,” “gained perspective,” “helped me plan,” and “gained illness management and decision-making skills.” Recommendations for intervention modification included (1) start program at diagnosis, (2) maintain phone-based approach, and (3) expand topics and modify format. Conclusion: Patients and caregivers unanimously found the intervention to be helpful and acceptable. After incorporating modifications, ENABLE CHF-PC is currently undergoing efficacy testing in a large randomized controlled trial.
Foot Width Changes Following Hallux Valgus Surgery
Authors: Tenenbaum Shay A. , Herman Amir , Bruck Nathan , Bariteau Jason T. , Thein Ran , Coifman Oded 
Published: June 2018

Background: Hallux valgus (HV) adversely affects quality of life. Patients frequently express concerns regarding postoperative foot appearance, foot width and footwear anticipations. However, only scarce data are available regarding postoperative foot width. Materials and Methods: Seventy-one cases with moderate to severe HV treated with scarf osteotomy were included. The average age was 55.7 years (range, 20-76), with average follow-up of 20.7 months (range, 6-96). Patients’ medical records were reviewed for demographic, operative, and radiographic data. Foot width was assessed radiographically by measuring both bone (distance between the first and fifth metatarsal heads) and soft tissue width (maximal distance of the soft tissue outline). Results: Preoperative HV deformity (mean hallux valgus angle [HVA] 35.8 degrees, intermetatarsal angle [IMA] 14.1 degrees, and distal metatarsal articular angle [DMAA] 15.2 degrees) was successfully corrected (postoperative mean HVA 13.7 degrees, IMA 6.9 degrees, and DMAA 7.7 degrees). Overall bony foot width was reduced by 5% and soft tissue foot width by 2%. Further analysis showed that 13 feet (18.3%) had increased (>5%) bone width, 26 feet (36.6%) with no change (±5%), and 32 feet (45.1%) for which the width decreased (>5%) postoperatively. Angular deformity (HVA, IMA, and DMAA) showed low correlation with postsurgery foot width. Conclusion: HV surgery effect on foot width was very limited, overall reducing foot width by 2%. Furthermore, in only about half of the patients, the postoperative foot width decreased, regardless of angular deformity magnitude. Patients with the widest feet had a decrease in foot width following surgery, whereas patients with the narrowest feet had an increase in foot width. Level of Evidence: Level III, comparative series.
Implementation of a text message intervention to promote behavioural change and weight loss among overweight and obese Brazilian primary care patients
Authors: Gusmão Lorenn L , Ribeiro Antonio L , Souza-Silva Maíra Viana Rego , Gomes Paulo R , Beleigoli Alline M , Cardoso Clareci S , Santo Karla , de Sousa Lidiane P , Marcolino Milena S 
Published: June 2018

Introduction Mobile-technology-based interventions are promising strategies for promoting behavioural change in obese patients. The aims of this study were to evaluate the feasibility of implementing a text message intervention, and to assess the effects of the intervention on body mass index (BMI) and self-reported behavioural change. Methods TELEFIT was a three-phase feasibility study comprising the following stages: (a) the development of text messages; (b) testing; and (c) a quasi-experimental pilot study in which patients who were engaged in obesity/overweight educational groups in public primary care centres in Belo Horizonte, Brazil, were recruited. A bank of text messages was drafted and reviewed by an expert panel, text message delivery software was developed and tested, and a pilot study assessed patients before and after receiving the intervention using validated questionnaires and body measures. The data were analysed using the Wilcoxon test. Results A total of 46 patients completed the follow-up; 93.5% were women and the median age was 42 years (interquartile range (IQR) 34–52 years). At four months, participants had a significant reduction in BMI (median 31.3 (IQR 28.2–34.6) vs. 29.9 (IQR 27.2–34.6) kg/m2, p < 0.001), systolic (median 125 (IQR 120–132) vs. 120 (IQR 110–130) mmHg, p = 0.013) and diastolic blood pressure (median 80 (IQR 70–100) vs. 80 (IQR 70–80) mmHg, p = 0.006), when compared to baseline. All patients reported to be satisfied and willing to continue receiving the intervention, and 93.3% felt that the intervention helped them change their behaviours. Discussion This study has shown that a text message intervention to promote behavioural change and weight loss was feasible and effective in a short-term period. Participants were satisfied and willing to continue receiving the SMS messages.
Concentrations of Intact Insulin Concurs With FDA and EMA Standards When Measured by HPLC in Different Parts of the Distribution Cold Chain
Authors: Moses Alan , Bjerrum Jesper , Hach Morten , Wæhrens Lars Holm , Toft Anders Dyhr 
Published: June 2018

Background: The article by Carter and Heinemann raised serious concerns about the concentrations of insulin in vials being sold in US pharmacies. To study the claims made in the manuscript, we reviewed Novo Nordisk data on insulin concentration. Methods: Insulin concentrations within vials from three different sources along the distribution chain were evaluated utilizing currently accepted US Pharmacopeia methodology: (1) insulin content and stability based on production batches covering 7 years of insulin production, (2) insulin content in samples returned to Novo Nordisk over the last three years in the United States, and (3) data from eight years of independent EMA testing. Results: The data demonstrated that without exception (1) insulin quality based on stability data was maintained, even in scenarios that stressed the normal recommendations for temperature storage conditions, (2) insulin content from the last three years of samples returned to Novo Nordisk from patients in the United States (233 vials) was within USP requirements recognized by FDA, and (3) ten years of independent EMA sampling of products obtained at wholesalers and pharmacies across the EU confirmed compliance (n = 43). Conclusions: The study by Carter and Heinemann utilized an LC-MS technique, which has not been validated for the quantification of insulin in pharmaceutical preparations. It appears likely that their findings are the result of the method utilized and not due to decreased insulin content in samples. However, recognizing the importance of maintaining Insulin content from production to the patient, Novo Nordisk supports continued evaluation of insulin distributed to pharmacies and patients utilizing validated techniques compliant with international pharmacopeias.
Long‐term changes in liver elasticity in hepatitis C virus‐infected patients with sustained virologic response after treatment with direct‐acting antivirals
Authors: Pietsch Veronika , Deterding Katja , Attia Dina , Ringe Kristina Imeen , Heidrich Benjamin , Cornberg Markus , Gebel Michael , Manns Michael Peter , Wedemeyer Heiner , Potthoff Andrej 
Published: June 2018

BackgroundThe use of interferon‐free direct‐acting antiviral agents (DAAs) is associated with a rapid short‐term decrease in liver stiffness in chronic hepatitis C‐infected patients with sustained virologic response (SVR).ObjectiveThe objective of this article is to evaluate long‐term changes in liver elasticity in hepatitis C patients with SVR using transient elastography (TE), FIB‐4 and APRI.MethodsA total of 143 patients were treated with DAAs and reached SVR. Patients received TE measurement (median (range)) at treatment start (baseline), follow‐up week 24 (FU24) and follow‐up week 96 (FU96). Laboratory data were examined at each date and FIB‐4 and APRI were calculated.ResultsLiver elasticity showed a significant decrease from baseline to FU24 (13.1 (3.1–75) kPa to 9.3 (2.9–69.1) kPa; p < 0.0001) and declined further until FU96 (7.9 (2.4–59.3) kPa; p < 0.0001). Liver inflammation and liver function parameters normalised during long‐term follow‐up. Progression of liver stiffness between FU24 to FU96 despite viral clearance was observed in 24 patients (17%). Long‐term liver stiffness progression was associated with aspartate aminotransferase levels and TE change from baseline to FU24.ConclusionDuring long‐term follow‐up, the majority of patients with SVR had further improved liver stiffness values. Still, a significant proportion of patients may show long‐term liver stiffness progression and thus continued TE follow‐up is recommended.
Efficacy and Tolerability of Peritendinous Hyaluronic Acid in Patients with Supraspinatus Tendinopathy
Authors: Álvarez Rey G , Balius Matas R , Buil Bellver MA , Cano Herrera C , Varela Sende L , Flores Lozano C 
Published: June 2018

Introduction: Physical therapy and peritendinous hyaluronic acid (HA) injections have both shown promising results in the treatment of shoulder tendinopathies. However, the superiority of treatment combining physical therapy and HA is unclear. Objectives: In this parallel-group, randomized, controlled trial, we investigated the efficacy and safety of peritendinous injection of HA in patients with persistent supraspinatus tendinopathy. To this end, we compared the therapeutic outcome of treatment with HA as an adjuvant to physical therapy with that of physical therapy as sole therapeutic intervention. Methods: 84 Patients with ultrasound-confirmed supraspinatus tendinopathy were randomized to receive either physical therapy + subacromial HA injections or physical therapy only. Treatment efficacy was assessed using a Visual Analog Scale (VAS) for pain and an Activities of Daily Living (ADL) scale. Other measures were the number of rehabilitation sessions and days needed for recovery, the Tampa Scale for Kinesiophobia (TSK), and the physician and patient’s perception of efficacy and tolerability. Patients were followed up for 90 days. Results: Overall, VAS and ADL scores showed a progressive decrease during the follow-up ( P<0.01 at all visits for both groups), without significant differences between groups. The TSK score decreased significantly more in the HA group than in the control group (3.6 vs. 2.4; P<0.001). Patients in the control group needed more rehabilitation sessions (28 vs. 22 in the HA group; P=0.006) and more days for returning to their pre-injury activity (32 vs. 20 in the HA group; P=0.013). Both patients and investigators perceived higher efficacy in the HA group than in the control group ( P=0.034). Both treatments were safe and well tolerated. Conclusion: Subacromial HA injections combined with physical therapy have high efficacy in the treatment of supraspinatus tendinopathy, leading to an earlier return to pre-injury activity and the need for fewer rehabilitation sessions, which may benefit both patients and the healthcare system.
Fracture of the Medial Sesamoid Bone in a professional soccer player
Authors: Gastaldi Llorens GM , Gastaldi Orquin E 
Published: June 2018

The incidence of medial sesamoid bone fracture is rare. Clinically they are often misdiagnosed as soft tissue injuries and often missed. Thus generates an important morbidity for the patient. Objectives: We present a case of turf-toe injury: plantar-plate rupture with medial sesamoid bone fracture in a contact athlete. Methods: A 19-year-old professional soccer player injured his left toe when he planted his foot during a sprint. He had an hyperextension and axial overload traumatism in his toe. On physical examination he had pain, swollen, ecchymosis, instability and loss of plantar-flexion strength. Radiographs showed a transverse medial sesamoid bone fracture with retraction > 3 mm. Magnetic resonance imaging confirmed a subluxation of the proximal phalange and a plantar plate disruption. Because of the completely deficient flexion, the sesamoid retraction, and the articular subluxation, surgery was recommended to restore the MTPJ anatomy. Reduction of the fracture and Repair of the plantar plate was performed using non-absorbable 2-0 Fiber wire sutures through a medial approach. Postoperatively, the patient was placed in a cast, for a total of 2 weeks. After that he began a rehabilitation program. Results: The patient had a complete recovery. He returned to participation in his team at 3 months. At final follow-up, his dorsiflexion ROM was 60 in the involved toe. Conclusion: Turf-toe and disorders of the sesamoid complex is an important injury, often misdiagnosed and usually undertreated. They had an incidence of 25% to 50% of residual pain and limited dorsiflexion in those cases. Despite the incidence of surgical treatment of 2%, we have found hopeful results with the open reduction and internal fixation of the fracture. Accurate and timely diagnosis and treatment can allow for full return to activity for these athletes.
Hamstring Graft Preparation Techniques for Anterior Cruciate Ligament Reconstruction
Authors: Vinagre Gustavo , Kennedy Nicholas , Cinque Mark , Hussain Zaamin , Olesen Morten , Chahla Jorge , LaPrade Robert 
Published: June 2018

Paste abstract here and remove the remaining text. *For structured abstracts, begin each section under a separate, bolded subheading. Suggested subheadings are below Introduction: Anterior Cruciate Ligament (ACL) tears are one of the most frequent injuries in young athletes. Given the importance of its biomechanical function in knee stability, ACL tears are treated surgically whenever there is sports activities demand. There are key factors in the ACL reconstruction such as graft choice, tunnel positioning, and graft diameter. Grafts less than 8 mm in diameter are a risk factor for re-rupture and relapse. This is especially important if hamstring grafts are used in female patients younger than 20 years old. Objectives: To describe in detail different hamstring graft preparation techniques to obtain an optimal and individualized graft according to patient´s anatomy and the ideal diameter and length for the reconstruction of the ACL. Methods: In the surgical lab, different hamstring graft preparation techniques with allografts, Endobutton femoral cortical suspension device (Smith and Nephew), FiberWire # 2 and FiberLoop # 2 (Arthrex) braided suture were prepare above the graft preparation station. Results: Different techniques of hamstring graft preparation were described in detail: Two-Strand with one tendon; Three-Strand with one tendon; Four-Strand with one and with two tendons; Five-Strand with two tendons; Six-Strand with two tendons and Eight-Strand with two tendons. Conclusion: It is essential to master the different hamstring graft preparation techniques in order to obtain an individualized graft with the appropriate diameter and length according to the patient´s anatomy, height and physical demand.
New minerals tsangpoite Ca5(PO4)2(SiO4) and matyhite Ca9(Ca0.5□0.5)Fe(PO4)7 from the D'Orbigny angrite
Authors: Hwang Shyh-Lung , Shen Pouyan , Chu Hao-Tsu , Yui Tzen-Fu , Varela Maria-Euginia , Iizuka Yoshiyuki 
Published: June 2018

AbstractTsangpoite, ideally Ca5(PO4)2(SiO4), the hexagonal polymorph of silicocarnotite, and matyhite, ideally Ca9(Ca0.5□0.5)Fe(PO4)7, the Fe-analogue of Ca-merrillite, were identified from the D'Orbigny angrite meteorite by electron probe microanalysis, electron microscopy and micro-Raman spectroscopy. On the basis of electron diffraction, the symmetry of tsangpoite was shown to be hexagonal,P63/morP63, witha= 9.489(4) Å,c= 6.991(6) Å,V= 545.1(6) Å3andZ= 2 for 12 oxygen atoms per formula unit, and that of matyhite was shown to be trigonal,R3c, witha= 10.456 (7) Å,c= 37.408(34) Å,V= 3541.6 (4.8) Å3andZ= 6 for 28 oxygen atoms per formula unit. On the basis of their constant association with the grain-boundary assemblage: Fe sulfide + ulvöspinel + Al–Ti-bearing hedenbergite + fayalite–kirschsteinite intergrowth, the formation of tsangpoite and matyhite, along with kuratite (the Fe-analogue of rhönite), can be readily rationalised as crystallisation from residue magmas at the final stage of the D'Orbigny meteorite formation. Alternatively, the close petrographic relations between tsangpoite/matyhite and the resorbed Fe sulfide rimmed by fayalite + kirschsteinite symplectite, such as the nucleation of tsangpoite in association with magnetite ± other phases within Fe sulfide and the common outward growth of needle-like tsangpoite or plate-like matyhite from the fayalite–kirschsteinite symplectic rim of Fe sulfide into hedenbergite, infer that these new minerals and the grain-boundary assemblage might represent metasomatic products resulting from reactions between an intruding metasomatic agent and the porous olivine–plagioclase plate + fayalite-kirschsteinite overgrowth + augite + Fe sulfide aggregates. Still further thermochemical and kinetics evidence is required to clarify the exact formation mechanisms/conditions of the euhedral tsangpoite, matyhite and kuratite at the grain boundary of the D'Orbigny angrite.
PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells
Authors: Kahn Josephine D. , Miller Peter G. , Silver Alexander J. , Sellar Rob S. , Bhatt Shruti , Gibson Christopher , McConkey Marie , Adams Dylan , Mar Brenton , Mertins Philipp , Fereshetian Shaunt , Krug Karsten , Zhu Haoling , Letai Anthony , Carr Steven A. , Doench John , Jaiswal Siddhartha , Ebert Benjamin L. 
Published: June 2018

Key Points
Truncating PPM1D mutations confer chemotherapy resistance, leading to the selective expansion of PPM1D-mutant cells in vitro and in vivo. PPM1D inhibitor treatment reverses the chemotherapy-resistance phenotype and selectively kills PPM1D-mutant cells.