bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Recurrent Rare SOX9 Variant (M469V) is Associated with Congenital Vertebral Malformations
Authors: Wu Nan , Wang Lianlei , Hu Jianhua , Zhao Sen , Liu Bowen , Li Yaqi , Du Huakang , Zhang Yuanqiang , Li Xiaoxin , Yan Zihui , Wang Shengru , Wang Yipeng , Zhang Jianguo , Wu Zhihong , Qiu Guixing 
Published: September 2019

Objective:
The genetic variations contributed to a substantial proportion of congenital vertebral
malformations (CVM). SOX9 gene, a member of the SOX gene family, has been implicated in
CVM. To study the SOX9 mutation in CVM patients is of great significance to explain the pathogenesis
of scoliosis (the clinical manifestation of CVM) and to explore the pathogenesis of SOX9-related
skeletal deformities.

Methods:
A total of 50 singleton patients with CVM were included in this study. Exome Sequencing
(ES) was performed on all the patients. The recurrent candidate variant of SOX9 gene was validated
by Sanger sequencing. Luciferase assay was performed to investigate the functional changes of this
variant.

Results:
A recurrent rare heterozygous missense variant in SOX9 gene (NM_000346.3: c.1405A>G,
p.M469V) which had not been reported previously was identified in three CVM patients who had the
clinical findings of congenital scoliosis without deformities in other systems. This variant was absent
from our in-house database and it was predicted to be deleterious (CADD = 24.5). The luciferase assay
demonstrated that transactivation capacity of the mutated SOX9 protein was significantly lower than that
of the wild-type for the two luciferase reporters (p = 0.0202, p = 0.0082, respectively).

Conclusion:
This SOX9 mutation (p.M469V) may contribute to CVM without other systematic
deformity, which provides important implications and better understanding of phenotypic variability
in SOX9-related skeletal deformities.
Beta Keton, Penanda Diabetes Tipe 1 pada Sensor Elektrokimia
Authors: Agnes Patria Pari 
Published: September 2019

Dewasa ini, diabetes mulai menjadi permasalahan global, dimana jumlah penderitanya terus mengalami peningkatan tiap tahunnya. Maraknya kasus diabetes ini mendorong dilakukannya pergerakan guna mengembangkan suatuperangkat sederhana yang mampu mendeteksi kadar gula darah. Dalam mini review ini dibahas potensi beta keton sebagai penanda diabetes tipe 1 pada sensor elektrokimia. Dijelaskan pula kelebihan dan kekurangannya.Kata kunci : beta keton, diabetes tipe 1, sensor elektrokimia
Factors affect green food consuption behavior of Consumers in Hanoi
Authors: Thoa Hoàng 
Published: September 2019

Green consumption has become an important academic and practical topic. Currently, consumers in Vietnam have started to aware about green food consumption. However, a recurring theme in the literature has been the attitude-behavior in green food consumption. Taking the cognitive view in studying consumer behaviors, this study theoretically developed and tested factors affects green food consumption behavior of consumers in Hanoi such as Attitude towards the environment, Attitude towards green consumption, Subjective norm of green consumption... Our data sample of 290 consumers in Hanoi provided supports for the hypotheses. Our study results thus contribute to the green consumption literature and the broader literature of consumer behavior. Implications and recommendations for further research are also discussed.
The platform approach to research and development using high-performance computing
Authors: Биряльцев Евгений Васильевич , Галимов Марат Разифович , Демидов Денис Евгеньевич , Елизаров Александр Михайлович 
Published: September 2019

Проанализированы предпосылки и обоснована актуальность создания открытой интернет/платформы, объединяющей технологии больших данных, высокопроизводительных вычислений и многосторонних интернет/платформ. Задуманная как экосистема для разработки и использования прикладного программного обеспечения (в том числе в области проектирования и научных исследований), платформа призвана сократить затраты и повысить качество разработки программного обеспечения для решения аналитических задач, возникающих на промышленных предприятиях, в научно/исследовательских организациях, у государственных органов и частных лиц. Представлен работающий прототип названной платформы, функционирующий с использованием суперкомпьютерных технологий и системы виртуализации рабочих столов.
Decision support systems in medicine
Authors: Малых Владимир Леонидович 
Published: September 2019

Современная медицина осваивает системы поддержки принятия решений (СППР). Анализируя российские и зарубежные источники, работа выявляет основные барьеры на пути создания СППР для медицины. Приводятся возможные подходы к преодолению концептуальных барьеров, предлагается возможное комплексное решение проблемы. Рассматривается гибридная модель СППР широкого класса для медицины. Результаты могут быть использованы разработчиками ИТ для построения СППР на основе научной и эмпирической компонент медицинских знаний.
ANALYSIS OF RISK FACTORS OF CHRONIC KIDNEY DISEASE ON PATIENTS WITH HEMODIALYSIS IN TANGERANG DISTRICT HOSPITAL
Authors: Arman Arman , Anggriani Yusi , Utami R Hesty 
Published: September 2019

Chronic kidney disease (CKD) is a major world health challenge in the 21st centuries. The prevalence of CKD in Indonesia based on the doctor's diagnosis is 0.2% while for Tangerang prevalence at 0.1%. There are no clear data of the predisposing factor of CKD in Banten province, especially in Tangerang. The purpose of this study was to analyze the risk factors CKD on patients with hemodialysis in Tangerang District Hospital. This study is an observational analytic research with case-control and cross sectional approach conducted in August to September 2017 at the Tangerang District Hospital. with 70 respondents in case group and 70 respondents in control group. The result of the bivariate analysis showed that 15 of 19 risk factors significantly (p ≤ 0.05) increased the risk of CKD with OR range 2,043 to 4,235. The result of multivariate analysis with logistic regression test showed that the most dominant risk factor for CKD was hypertension with OR 21,806 (95% C.I. 1,015- 486,554) and p = 0,049. There are 15 risk factors that could increase the risk of CKD. the most dominant risk factor for CKD was hypertension
Keywords: Risk factors, chronic kidney disease, hemodialysis
New Dynamics of Risk and Responsibility: Expanding the Vision for Accident Compensation
Authors: Gaskins Richard 
Published: September 2019

A holistic approach towards risk management must recognise the interconnectedness of economic and social structures. In this article, Gaskins focuses on the concept of “network societies”, which look to increase communication and organisation within their sphere of influence. While recognising that networks have the ability to regulate the distribution of risk across economic groups in society, Gaskins highlights the potential for networks to displace risk onto vulnerable sectors, thus essentially increasing risk levels for those outside the network. In the realm of health and safety, this can push the responsibility for occupational accidents onto already burdened families and communities. The development of the ACC system in New Zealand originally embraced a coherent approach to risk management. Gaskins argues that this approach has become displaced, and should be reestablished as the foundation of the ACC system. This article does not attempt to prescribe a way forward for ACC, but rather aims to highlight areas of particular concern, which require consideration in relation to the further development and advancement of ACC in New Zealand.
Instrucciones sobre la estructura del manuscrito de la Revista Cátedra
Authors: Gallardo Verónica Simbaña 
Published: September 2019

El presente artículo tiene como objetivo explicar la presentación, estructura y envío del manuscrito de la Revista Cátedra. Estas instrucciones son de uso obligado, pues, hoy en día, es necesario regirse a normas para que el artículo cumpla con estándares de calidad e indexación. La revista se alinea a la estructura IMRAD, que son las siglas de los cuatro apartados de un artículo: introducción, materiales y métodos, resultados y discusión.
Aunque el formato IMRAD solo incluye el cuerpo del artículo hay otros aspectos importantes que se deben considerar: tema, autores, resumen, palabras clave, revisión de la literatura, agradecimiento (opcional) y bibliografía. En este artículo, de una manera clara, descriptiva, concisa y fácil de entender, se detalla cada componente del manuscrito que se debe enviar cuando se quiera publicar con la Revista Cátedra. Las instrucciones presentadas en este artículo pretenden mejorar la escritura científica de los manuscritos y garantizar su publicación, pues este es el medio más efectivo que tiene un investigador para mostrar su trabajo y los resultados de un proceso investigativo.
La Revista Cátedra tiene como bases teóricas las Ciencias de la Educación en sus diferentes especialidades y niveles educativos; sobre la base de estos principios y la reflexión de la práctica docente, publicará artículos originales, innovadores y estratégicos para fortalecer al perfeccionamiento del proceso educativo y su vinculación con la comunidad científica.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE SNOWBALL THROWING UNTUK MENINGKATKAN HASIL BELAJAR SISWA KONSEP SISTEM PERNAPASAN MANUSIA PADA KELAS XI SMA PGRI 1 AMBON
Authors: Latuperissa Friescilya Beatrix , Rumahlatu Dominggus 
Published: September 2019

Background: Education is defined as a process using certain models so that one can obtain knowledge, understanding, and ways of behaving according to needs. In this study aims to determine the effect of applying the snowball throwing learning model in improving learning outcomes on the concept of the human respiratory system in class XI SMA PGRI 1 Ambon
Method: This study was conducted from February 14 to March 14, 2018 in class XI SMA PGRI 1 Ambon.
Results: Through cooperative design shows that there is an increase in learning outcomes after using the snowball throwing model.
Conclusion: The application of the Snowball Throwing type cooperative learning model can improve the learning outcomes of the concept of human respiratory system in class XI IPA2 students of SMA PGRI 1 Ambon showing the level of success of students seen from cognitive, affective, psychomotor and final grades.
PENGGUNAAN METODE DUPONT DAN RADAR DALAM HUBUNGAN DENGAN PENGUKURAN KINERJA KEUANGAN SETELAH AKUISISI (Study Kasus PT Tifico Fiber Indonesia Tbk).
Authors: Ansari Irman 
Published: September 2019

ABSTRACTTujuan dari penelitian ini adalah untuk menilai kinerja keuangan PT Tifico Tbk sebelum dan setelah akuisisi oleh beberapa perusahaan konsorsium dari perusahaan Jepang PT Teijin Limited, dan memperbandingkan kinerja PT Tifico Tbk dengan kinerja beberapa perusahaan yang sejenis dalam industri polyester yang tercatat pada Bursa Efek Indonesia. Data yang digunakan sebagai bahan analisa yaitu data laporan keuangan masing masing perusahaan. Pada PT Tifico Tbk sebelum akuisisi, data laporan keuangan yang dianalisa pada periode 2006 ~ 2009, sedangkan data laporan keuangan yang dianalisa pada PT Tifico Tbk setelah akuisisi dan beberapa perusahaan industri sejenis yang tercatat pada Bursa Efek indonesia pada periode 2010 ~ 2014. Metode penelitian yang digunakan penulis yaitu penelitian deskriptif dengan menganalisa laporan keuangan dengan data quantitatif dan teknik yang digunakan untuk penganalisaan dengan metode Dupont dan metode Radar. Hasil penelitian secara konkret dapat disebutkan penilaian kinerja perusahaan baik dengan metode Dupont maupun dengan metode Radar memperlihatkan hasil yang saling memperkuat. Hasil analisa dapat disimpulkan bahwa: PT Tifico setelah akuisisi mempunyai kinerja yang lebih baik dibandingkan dengan sebelum akuisisi dan juga lebih baik dari Perusahaan yang sejenis, namun belum dikategorikan sehat dibandingkan dengan kinerja industri secara umum.
RELASI KEKUASAAN ANTARA TIM MANAJERIAL DAN REDAKSI LIPUTAN
Authors: Andriana Dina 
Published: September 2019

Power relations reveal hidden things that occur in the Works process between agents in Social practice related to media political economy practices. Media competition requires agents (workers) to compete with innovation and more creatively giving birth to program that are able to attract a large audience. So editors become depressed in producing a program content. Every agents in television media conducts Social practices to channel the relationship between relations which directly or indirectly, or equal or not equal, this indicates the existence of Power. The Research has conducted in the critical paradigma domain, with the Robert K Yin case Study method, where the The of Research was explanatory study regarding the Power relations between manajerial teams and editor Liputan 6 Pagi teams using the theory of Foucault’s Discourse of Power and Knowledge. The Result showed that there were elementer of combination of dominance Power relations and unequal govermentality of Power.

Keywords: Power Relations, Foucault, Manajerial Teams, News Program, Editor Teams, Liputan 6 Pagi, SCTV.
THE EFFECT OF QUALITY OF WORK LIFE ON ORGANIZATIONAL COMMITMENT LECTURER IN MUHAMMADIYAH UNIVERSITY OF CIREBON
Authors: Badawi Badawi , Leisy Leisy 
Published: September 2019

The aim of study was to determine and analyze the influence of the quality of work life to the commitment of lecturer organization at Muhammadiyah University of Cirebon.
The data of this research were obtained from the questionnaire (primary) which was disseminated on the lecturers of Universitas Muhammadiyah Cirebon as many as 51 samples from the population of 257 people. Data analysis method used in this research using simple regression showed that influenced significantly and positively because Fhitung 25.819 bigger than value Ftabel 3.18 and value of Adjusted R Square equal to3.32 or 33.2% which indicate influence of quality of work life to organizational commitment. This shows that there are still 66.8% factors or other variables that affect the organization's commitment. Inadequate and fair reward indicators are the most influential factors on organizational commitment.
Mise en évidence par spectrophotométrie d'une diffusion partielle de l'eau des inclusions fluides lors du chauffage des minéraux
Authors: Calas Georges 
Published: September 2019

Une diffusion rapide de l'eau des inclusions fluides est détectée qualitativement dans les spectres d'absorption ultraviolette des fluorites vers 300° C, ce qui crée une erreur systématique dans les analyses de ces inclusions.
Les inclusions fluides en géochimie-pétrologie : tendances actuelles
Authors: Weisbrod Alain , Poty Bernard , Touret Jacques 
Published: September 2019

L'étude analytique quantitative des inclusions fluides, si elle est menée conjointement aux études géochimiques et minéralogiques, apporte un grand nombre de données nouvelles sur la plupart des problèmes pétrologiques. Elle suscite en outre de nouvelles recherches expérimentales.
Les hypothèses de base de la méthode sont rapidement discutées et une brève revue des techniques est effectuée.
L'interprétation des mesures, qui se réfère souvent à des systèmes simplifiés, tels que H₂O-NaCl et H₂O-CO₂, pose souvent des problèmes aux chercheurs peu entraînés à ce genre de méthode : aussi semble-t-il intéressant d'en résumer les principes.
Les exemples choisis portent essentiellement sur l'utilisation en pétrologie : caractérisation des mécanismes du métamorphisme (faciès granulite et métamorphisme anchi à épizonal de la croûte océanique) ; utilisation en géothermo-barométrie (métamorphisme des massifs cristallins externes dans les Alpes franco-suisses et phénomènes hydrothermaux de basse pression) ; évaluations quantitatives des phénomènes de transport de matière.
Utilisation de la spectrométrie infrarouge pour l'étude des inclusions fluides des minéraux : intérêts et limites
Authors: Calas Georges , Huc Alain-Yves , Pajot Bernard 
Published: September 2019

It is possible to detect in situ the main components of fluid inclusions in a short time by infrared spectrometry : water, carbon dioxide and organic matter, as their relative proportions. On the other hand, it permits to estimate the volumetric importance of those inclusions in the mineral. The interest for crystal growth studies is drawn out, but also the limits of the method, principally related to mineral absorption in the majority of the cases (with the exception of natural halogenides) which can make the fluid inclusions spectra more difficult to study.
Efek Lumatan Daun Pepaya (Carica Papaya L.) terhadap Proses Penyembuhan Luka Bakar Derajat II Dangkal Pada Tikus Putih (Rattus Novergicus) Galur Wistar
Authors: Setyani Putri 
Published: September 2019

Luka bakar masih menjadi masalah kesehatan utama di negara berkembang. Luka bakar derajat II adalah tipe luka bakar yang biasa ditemukan pada kejadian luka bakar dirumah. Penatalaksanaan yang tidak tepat dapat menimbulkan efek buruk pada penyembuhan. Saat ini perawatan luka bakar secara umum adalah menggunakan Silver Sulfadiazine 1%. Penelitian ini bertujuan untuk mengetahui efek lumatan daun pepaya dalam mempercepat penyembuhan luka bakar derajat II. Penelitian ini merupakan penelitian murni (true experimental) dengan rancangan pretest-posttest only control group design. Variabel yang diukur adalah kecepatan penyembuhan luka yang didapatkan dengan mengukur prosentase kontraksi luka. Sampel terdiri dari 2 kelompok masing-masing 9 ekor tikus, yaitu kelompok lumatan daun pepaya (kelompok 1) dan kelompok Silver Sulfadiazine 1% (kelompok 2). Hasil penelitian menunjukan ratarataÂ prosentasi kontraksi luka pada kelompok 1 sebesar 92,7% dan rata-rata prsentasi kontraksi luka pada kelompok 2 sebesar 89,7%. Uji statistik T-Test 2 Sampel menunjukan kedua kelompok memiliki signifikansi sebesar 0,002 < Î± (0,05). Berdasarkan hasil diatas dapat disimpulkan bahwa lumatan daun pepaya mempunyai efek dalam mempercepat penyembuhan luka bakar derajat II.
Dragonfly Imaging of the Galaxy NGC 5907: A Different View of the Iconic Stellar Stream
Authors: van Dokkum Pieter , Gilhuly Colleen , Bonaca Ana , Merritt Allison , Danieli Shany , Lokhorst Deborah , Abraham Roberto , Conroy Charlie , Greco Johnny P. 
Published: September 2019

Abstract
In 2008 it was reported that the stellar stream of the edge-on spiral NGC 5907 loops twice around the galaxy, enveloping it in a giant corkscrew-like structure. Here we present imaging of this iconic object with the Dragonfly Telephoto Array, reaching a 1σ surface brightness level of μ

g
= 30.3 mag arcsec−2 on spatial scales of 1′ (the approximate width of the stream). We find a qualitatively different morphology from that reported in the 2008 study. The Dragonfly data do not show two loops but a single curved stream with a total length of 45′ (220 kpc). The surface brightness of the stream ranges from μ

g
≈ 27.6 mag arcsec−2 to μ

g
≈ 28.8 mag arcsec−2, and it extends significantly beyond the region where tidal features had previously been detected. We find a density enhancement near the luminosity-weighted midpoint of the stream which we identify as the likely remnant of a nearly disrupted progenitor galaxy. A restricted N-body simulation provides a qualitative match to the detected features. In terms of its spatial extent and stellar mass the stream is similar to Sagittarius, and our results demonstrate the efficacy of low surface brightness-optimized telescopes for obtaining maps of such large streams outside the Local Group. The census of these rare, relatively high mass events complements the census of common, low-mass ones that is provided by studies of streams in the Milky Way halo.
Why article-level metadata is important to monitor agreements
Authors: Marques Mafalda , Morthorst Anna Mette , Manista Frank 
Published: September 2019

The Knowledge Exchange (KE) Monitoring Open Access (OA) task and finish group has undertaken research on agreements with OA elements (e.g. agreements with APC discounts, offsetting agreements, read and publish agreements) set between consortia from KE countries and major publishers between 2016 and early 2019. It assessed agreements with OA elements to investigate what OA article-level metadata consortia request from publishers and what metadata publishers deliver to consortia.
With more academic publishing agreements including OA elements, publishers must account for the articles published OA. For example, article processing charges may be paid directly by authors, institutions or research funders and the paying entity has the right to know what research it has funded. Another example includes agreements with a cap on the number of articles that can be published OA. In these cases, consortia and institutions must monitor how many articles are being published OA and they can only do so if publishers deliver OA article-level metadata reports on a regular basis.
With Plan S research funders requiring a full transition to OA by 2021, the delivery of OA metadata becomes critical to monitor publishers’ compliance with Plan S requirements for transformative arrangements.
In its research, the KE Monitoring OA group used recommendations issued by KE and the Efficiency and Standards for Article Charges (ESAC) initiative to develop a list of OA article-level metadata to evaluate if consortia requested OA metadata and if publishers delivered it. The research findings showed that not all consortia agreements requested the OA metadata as recommended by KE and ESAC. Most importantly, none of the publishers provided all the metadata that the consortia requested. Publishers also did not deliver exactly the same OA metadata across countries and this may be due lack of consistency in their practices.
The research findings can be used as a benchmark to monitor how major publishers were performing in KE countries until early 2019 and prior to Plan S comes into effect in 2021. To assist in the process OA metadata collection, the KE Monitoring OA task and finish group created a template based on the KE and ESAC recommendations that consortia can use as a guideline for what OA metadata to request from publishers and that publishers can use as a reporting tool.
Laser Programmable Patterning of RGO/GO Janus Paper for Multiresponsive Actuators
Authors: Ma Jia‐Nan , Mao Jiang‐Wei , Han Dong‐Dong , Fu Xiu‐Yan , Wang Ya‐Xin , Zhang Yong‐Lai 
Published: September 2019

AbstractGraphene oxide (GO) with tunable physical/chemical properties is a versatile material for smart bimorph actuators. Using GO or its derivatives (e.g., reduced GO, RGO) as an active material, actuators can be manipulated under various external stimuli including moisture, light, temperature, and electricity. However, most of these GO‐based actuators respond to a solo stimulus, which limits its cutting‐edge applications in soft robotics. Here, the programmable patterning of RGO/GO Janus paper using a threshold‐controlled direct laser writing (DLW) technology is reported. By combining the RGO/GO Janus paper with a common thermally expansive polymer layer, a moisture, light, and electricity multiresponsive actuator is fabricated, in which the RGO interlayer plays multiroles including moisture‐passive layer, photothermal/electrothermal layer, thermal conductive layer, and inert layer for thermal expansion. As a proof of concept, multiresponsive actuators including a bidirectional cantilever and a smart curtain are fabricated, demonstrating the great potential for developing soft robots.