bluuebunny/crossref_metadata_2025_split huggingface dataset:
Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation
Authors: Ben Jingjing , Jiang Bin , Wang Dongdong , Liu Qingling , Zhang Yongjing , Qi Yu , Tong Xing , Chen Lili , Liu Xianzhong , Zhang Yan , Zhu Xudong , Li Xiaoyu , Zhang Hanwen , Bai Hui , Yang Qing , Ma Junqing , Wiemer Erik A. C. , Xu Yong , Chen Qi 
Published: April 2019

AbstractMacrophage-orchestrated, low-grade chronic inflammation plays a pivotal role in obesity and atherogenesis. However, the underlying regulatory mechanisms remain incompletely understood. Here, we identify major vault protein (MVP), the main component of unique cellular ribonucleoprotein particles, as a suppressor for NF-κB signaling in macrophages. Both global and myeloid-specific MVP gene knockout aggravates high-fat diet induced obesity, insulin resistance, hepatic steatosis and atherosclerosis in mice. The exacerbated metabolic disorders caused by MVP deficiency are accompanied with increased macrophage infiltration and heightened inflammatory responses in the microenvironments. In vitro studies reveal that MVP interacts with TRAF6 preventing its recruitment to IRAK1 and subsequent oligomerization and ubiquitination. Overexpression of MVP and its α-helical domain inhibits the activity of TRAF6 and suppresses macrophage inflammation. Our results demonstrate that macrophage MVP constitutes a key constraint of NF-κB signaling thereby suppressing metabolic diseases.
Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification
Authors: Hong Senlian , Shi Yujie , Wu Nicholas C. , Grande Geramie , Douthit Lacey , Wang Hua , Zhou Wen , Sharpless K. Barry , Wilson Ian A. , Xie Jia , Wu Peng 
Published: April 2019

AbstractChemoenzymatic modification of cell-surface glycan structures has emerged as a complementary approach to metabolic oligosaccharide engineering. Here, we identify Pasteurella multocida α2-3-sialyltransferase M144D mutant, Photobacterium damsela α2-6-sialyltransferase, and Helicobacter mustelae α1-2-fucosyltransferase, as efficient tools for live-cell glycan modification. Combining these enzymes with Helicobacter pylori α1-3-fucosyltransferase, we develop a host-cell-based assay to probe glycan-mediated influenza A virus (IAV) infection including wild-type and mutant strains of H1N1 and H3N2 subtypes. At high NeuAcα2-6-Gal levels, the IAV-induced host-cell death is positively correlated with haemagglutinin (HA) binding affinity to NeuAcα2-6-Gal. Remarkably, an increment of host-cell-surface sialyl Lewis X (sLeX) exacerbates the killing by several wild-type IAV strains and a previously engineered mutant HK68-MTA. Structural alignment of HAs from HK68 and HK68-MTA suggests formation of a putative hydrogen bond between Trp222 of HA-HK68-MTA and the C-4 hydroxyl group of the α1-3-linked fucose of sLeX, which may account for the enhanced host cell killing of that mutant.
Hydrophobic carbon dots with blue dispersed emission and red aggregation-induced emission
Authors: Yang Haiyao , Liu Yingliang , Guo Zhouyi , Lei Bingfu , Zhuang Jianle , Zhang Xuejie , Liu Zhiming , Hu Chaofan 
Published: April 2019

AbstractCarbon dots (CDs) have been studied for years as one of the most promising fluorescent nanomaterials. However, CDs with red or solid-state fluorescence are rarely reported. Herein, through a one-pot solvothermal treatment, hydrophobic CDs (H-CDs) with blue dispersed emission and red aggregation-induced emission are obtained. When water is introduced, the hydrophobic interaction leads to aggregation of the H-CDs. The formation of H-CD clusters induces the turning off of the blue emission, as the carbonized cores suffer from π-π stacking interactions, and the turning on of the red fluorescence, due to restriction of the surfaces’ intramolecular rotation around disulfide bonds, which conforms to the aggregation-induced-emission phenomenon. This on-off fluorescence of the H-CDs is reversible when the H-CD powder is completely dissolved. Moreover, the H-CD solution dispersed in filter paper is nearly colorless. Finally, we develop a reversible two switch-mode luminescence ink for advanced anti-counterfeiting and dual-encryption.
Terahertz electromagnetically-induced transparency of self-complementary meta-molecules on Croatian checkerboard
Authors: Zhao Zhenyu , Zheng Xiaobo , Peng Wei , Zhang Jianbing , Zhao Hongwei , Shi Wangzhou 
Published: April 2019

AbstractA terahertz (THz) electromagnetically-induced transparency (EIT) phenomenon is observed from two types of self-complementary meta-molecules (MMs) based on rectangular shaped electric split-ring resonators (eSRR) on Croatian checkerboard. Each MM contains a couple of identical size eSRRs and a couple of structural inversed eSRRs twisted π/2 in checkerboard pattern. In the first type of MM (type-I), the gap is in the middle line of eSRR. In the second type of MM (type-II), the gap is on the two arms of eSRR. Both types of MMs exhibit EIT effect. A maximum 20 ps group delay is observed at the transparency window of 0.63 THz in type-I MM; while a maximum 6.0 ps group delay is observed at the transparent window of 0.60 THz in type-II MM. The distribution of surface currents and electrical energy reveals that only CeSRR contribute to the transparency window as well as the side-modes in type-I MM, where the current leakage via contact point contributes to the low-frequency side-mode, and the coupled local inductive-capacitive (LC) oscillation in CeSRRs contributes to the high-frequency side-mode. In type-II MM, however, the localized dipolar oscillator of CeSRR contributes to the low-frequency side-mode; while the hybridization of dipole oscillation on eSRR and LC resonance on CeSRR contributes to the high-frequency side-modes. Our experimental findings manifest a new approach to develop THz slow-light devices.
Maternal body mass index moderates antenatal depression effects on infant birthweight
Authors: Petursdottir Maack Heidrun , Skalkidou Alkistis , Sjöholm Anna , Eurenius-Orre Karin , Mulic-Lutvica Ajlana , Wikström Anna-Karin , Sundström Poromaa Inger 
Published: April 2019

AbstractObesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a large for gestational age (LGA) infant. However, the effect of co-morbid depression has received little attention. This study set out to investigate if maternal body mass index (BMI) in early pregnancy moderates antenatal depression effects on infant birthweight. 3965 pregnant women participated in this longitudinal cohort study, where cases (n = 178) had Edinburgh Postnatal Depression Scale (EPDS) score ≥ 17 in gestational week 17 or 32, and remaining women (n = 3787) were used as controls. The influence of maternal BMI and antenatal depressive symptoms on standardized birthweight was evaluated by analysis of covariance, with adjustment for relevant confounders. Depressed women with BMI 25.0 kg/m2 or more gave birth to infants with significantly greater standardized birthweight than non-depressed overweight women, whereas the opposite pattern was noted in normal weight women (BMI by antenatal depressive symptoms interaction; F(1,3839) = 6.32; p = 0.012. The increased birthweight in women with co-prevalent overweight and depressive symptoms was not explained by increased weight gain during the pregnancy. Maternal BMI at the beginning of pregnancy seems to influence the association between antenatal depressive symptoms and infant birthweight, but in opposite directions depending on whether the pregnant women is normal weight or overweight. Further studies are needed to confirm our finding.
Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice
Authors: Azushima Kengo , Uneda Kazushi , Wakui Hiromichi , Ohki Kohji , Haruhara Kotaro , Kobayashi Ryu , Haku Sona , Kinguchi Sho , Yamaji Takahiro , Minegishi Shintaro , Ishigami Tomoaki , Yamashita Akio , Tamura Kouichi 
Published: April 2019

AbstractThe underlying pathogenesis of chronic kidney disease involves an activated renin-angiotensin system and systemic inflammation which ultimately develop renal injury. Rikkunshito (RKT) has been reported to exert anti-fibrotic and anti-inflammatory effects through enhancement of ghrelin signaling pathway. In this study, we investigated the effects of RKT on renal fibrosis and inflammation in angiotensin II (Ang II)-induced renal injury model. Ang II-infused mice exhibited hypertension, cardiac hypertrophy, increases in blood urea nitrogen and serum creatinine, moderate albuminuria and renal pathological changes such as mild urinary cast, interstitial macrophage infiltration and modest interstitial fibrosis. RKT had no evident effects on the Ang II-induced renal functional insufficiency and fibrosis, but attenuated renal interstitial macrophage infiltration. In addition, RKT significantly restored the Ang II-induced alteration in the expression of renal fibrosis- and inflammation-related genes such as type 3 collagen, transforming growth factor-β, monocyte chemoattractant protein-1 and interleukin-6. Furthermore, although RKT did not affect the expression of renal ghrelin receptor, an Ang II-induced decrease in renal sirtuin 1 expression, a critical down-stream pathway of the ghrelin receptor, was restored by RKT. These findings suggest that RKT potentially has a renal anti-inflammatory effect in the development of renal injury, and this effect could be mediated by the ghrelin signaling pathway.
Assessment of body adiposity in preterm children at the beginning of school age
Authors: Perenc Lidia , Zajkiewicz Katarzyna , Drzał-Grabiec Justyna , Majewska Joanna , Cyran-Grzebyk Barbara , Walicka-Cupryś Katarzyna 
Published: April 2019

AbstractIn Poland, like in other developed countries, 6.3% of babies are born prematurely. Preterm babies suffer from numerous health issues. The aim of the study was to assess body adiposity in preterm children at the beginning of school age. The study population consisted of 61 children aged 5 to 8 years who had been born preterm. We performed standard anthropometric measurements according to internationally recognized methodology. The following parameters were used: Body Weight (BW), Body Heigh (BH), Waist Circumference (WC), Body Mass Index (BMI), Waist to Height Ratio (WtHR), Triceps Skinfold Thickness (TST), Subscapular Skinfold Thickness (SST), Umbilical Skinfold Thickness (UST), as well as total sum of the above parameters, or the Global Adiposity (GA). The anthropometric measurements were taken according to international anthropometric methodology. All anthropometric parameters for body adiposity were significantly lower in the study population than in the reference system. We found a statistically significant relationship between: the number of fetuses and: UST (p = 0.007) and z-score UST (p = 0.030); combined number of unfavorable perinatal events: and UST (p = 0.013) and z-score UST (p = 0.007), GA (p = 0.038) and z-score GA (p = 0.040). Preterm children who are about to start school have significantly lower values of anthropometric features that characterize their body adiposity. In preterm children at early school age number of fetuses diversifies UST; and combined number of unfavorable perinatal events diversifies UST and GA. It is recommended that more studies are conducted on positively oriented modification of body adiposity in these children, as well as its long term monitoring.
DUXAP10 inhibition attenuates the proliferation and metastasis of hepatocellular carcinoma cells by regulation of the Wnt/β-catenin and PI3K/Akt signaling pathways
Authors: Han Kun , Li Chunqi , Zhang Xin , Shang Liang 
Published: April 2019

Abstract
The long non-coding RNA DUXAP10 has been involved in the development, progression, and metastasis in several human cancers, but its biological function and underlying mechanism in hepatocellular carcinoma (HCC) still undetermined. The present study was proposed to explore the effect of DUXAP10 on the growth and metastasis of HCC cells and the potential mechanisms involved. The results showed that DUXAP10 is dramatically elevated in HCC tumor tissues and cell lines. Knockdown of DUXAP10 by DUXAP10 si-RNA significantly inhibited the cell viability, proliferation and induce the apoptosis of HCC cell line. Meanwhile, inhibition of DUXAP10 attenuates the cell migration, invasion, and epithelial–mesenchymal transition (EMT) process. No significant change of JNK MAPK pathway was detected in DUXAP10 siRNA transfected HCC cell lines. The β-catenin and pAkt levels were decreased in the Hep G2+DUXAP10 siRNA and SMMC7721+DUXAP10 siRNA groups, while the activation of Wnt/β-catenin or PI3K/Akt suppressed the inhibition of DUXAP10 siRNA on cell proliferation and migration. Collectively, DUXAP10 plays a critical role in regulating HCC development, potentially by regulating EMT and cell proliferation through the PI3K/Akt and Wnt/β-catenin signaling. Inhibition of DUXAP10 in HCC HepG2 cells could attenuate the EMT and cell proliferation and invasion. Therefore, DUXAP10 might be a promising therapy target to inhibit the growth of HCC.
Using genome editing to engineer universal platelets
Authors: Lawrence Moyra , Mueller Annett , Ghevaert Cedric 
Published: April 2019

AbstractGenome editing technologies such as zinc finger nucleases, TALENs and CRISPR/Cas9 have recently emerged as tools with the potential to revolutionise cellular therapy. This is particularly exciting for the field of regenerative medicine, where the large-scale, quality-controlled editing of large numbers of cells could generate essential cellular products ready to move towards the clinic. This review details recent progress towards generating HLA Class I null platelets using genome editing technologies for β2-microglobulin deletion, generating a universally transfusable cellular product. In addition, we discuss various methods for megakaryocyte (MK) production from human pluripotent stem cells and subsequent platelet production from the MKs. As well as simply producing platelets, differentiating MK cultures can enable us to understand megakaryopoiesis in vivo and take steps towards ameliorating bleeding disorders or deficiencies in MK maturation in patients. Thus by intersecting both these areas of research, we can produce optimised differentiation systems for the production of universal platelets, thus offering a stable supply of platelets for difficult-to-match patients and providing areas with transmissible disease concerns or an unpredictable supply of platelets with a steady supply of quality-controlled platelet units.
Skywave delay estimation in Enhanced Loran based on Extended Invariance Principle Weighted Fourier transform and Relaxation algorithm
Authors: Zhang Kai , Wan Guobin , Li MinChao , Xi Xiaoli 
Published: April 2019

A high precision algorithm is proposed to estimate the Enhanced Loran skywave delay, which is based on an Extended Invariance Principle Weighted Fourier transform and Relaxation (EXIP‐WRELAX) algorithm. It is an innovation on the application of the skywave interference estimation algorithm in the Enhanced Loran receiver. Compared with existing algorithms, this algorithm has higher accuracy and lower computational complexity. Simulation results show that the proposed algorithm reduces the estimated error accuracy from ∼1000 to 50 m. At the same time, accurate search over the entire frequency domain is avoided, which greatly reduces the computational complexity. The algorithm is also proved by the off‐air data.
Mütterliche Notfälle: methodisch qualifiziert – schlüssig handeln
Authors: Strauss Alexander , Gräsner Jan-Thorsten 
Published: April 2019

ZusammenfassungMütterliche Notfälle können den Ausgang von Schwangerschaft und Geburt in erheblichem Maße beeinflussen. Da bedrohliche Situationen in nahezu jeder Lebenssituation und zu jedem beliebigen Zeitpunkt während der Schwangerschaft auftreten können, ist ein Notfalltransport in eine Klinik nicht immer rasch genug möglich. In diesen Fällen hat die Patientinnenversorgung außerhalb einer stationären perinatologischen Einrichtung zumindest zu beginnen. Dabei darf sich der Fokus des Rettungsteams nicht nur auf sich direkt aus der Schwangerschaft ergebende Befunde (z. B. überraschend beginnende oder besonders rasch verlaufende Geburtsbestrebungen, vorzeitiger Blasensprung, Nabelschnurvorfall) konzentrieren, sondern muss ebenso auf Schwangerschaft-koinzidenten Ereignissen (u. a. Akutes Abdomen, Trauma, Uterusverletzung, Anaphylaxie) liegen. Der unvermeidlichen geburtshilflichen Unerfahrenheit des Notarztes gepaart mit den situationsimmanenten Beschränktheiten der Mittel am Einsatzort sind konkrete situationsadaptierte Handlungsschemata entgegenzustellen. Ballastfreies perinatologisches Basiswissen verbunden mit klinischem Pragmatismus markieren hierbei die Eckpunkte ihrer Zweckdienlichkeit: methodisch zu qualifizieren um schlüssig zu handeln.
Tränenwegsspülung – Schritt für Schritt
Authors: Leberkühne Lisanne 
Published: April 2019

ZusammenfassungDas Leitsymptom Epiphora kann neben einer Hypersekretion oder funktionellen Tränenabflussbehinderung auch durch eine anatomische Tränenwegsobstruktion bedingt sein. Hierbei kann eine relative Obstruktion (Stenose) oder absolute Obstruktion (Verschluss) vorliegen. Eine einfache und schnelle Methode zur Diagnostik und Lokalisation oder zum Ausschluss einer Obstruktion ist die Tränenwegsspülung.
Anular Closure RCT – Interpretation der Ergebnisse und Bedeutung für die klinische Entscheidungsfindung im Jahr 2019
Authors: Thomé Claudius 
Published: April 2019

ZusammenfassungObwohl die lumbale Bandscheibenoperation als häufigster wirbelsäulenchirurgischer Eingriff mit sehr guten klinischen Ergebnissen in Verbindung gebracht wird, besteht ein relevantes Reherniations- und Reoperationsrisiko. Dies gilt insbesondere für Patienten mit hohen Bandscheiben und großen Anulusdefekten, also für bis zu 30 % des Gesamtkollektivs. Um die Rezidivraten nach Mikrodiskektomie zu senken, wurde ein Anulusverschlussimplantat (ACD) entwickelt und kürzlich in einem großen Multicenter-RCT evaluiert. Dieser Übersichtsartikel soll die publizierten Daten und deren Bedeutung für die wirbelsäulenchirurgische Praxis zusammenfassen.In der Kontrollgruppe des RCT konnte die hohe Rezidivrate von ca. 25 % für diese Hochrisikopopulation nach limitierte Mikrodiskektomie bestätigt werden. Die Reherniationsrate wurde durch das Implantat um die Hälfte gesenkt, so dass bei einer Häufigkeit von Implantat-bedingten Revisionen von unter 3 % auch eine Halbierung der Reoperationsrate erzielt wurde. Die nach harten Kriterien definierte Erfolgsquote betrug ohne Implantat 66 % und mit ACD 76 %. Diese statistisch signifikanten Unterschiede in Reoperations- und Erfolgsraten führten nach 3 Jahren auch zu einem signifikanten Outcomevorteil. Auffällig waren häufige Endplattenveränderungen bei ACD-Patienten, die zwar ohne klinische Konsequenzen blieben, aber eine Langzeitbeobachtung anraten.Bei der Hochrisikopopulation macht ein Anulusverschluss nach aktueller Datenlage Sinn und verbessert das Operationsergebnis, so dass der Patientenselektion entscheidender Stellenwert zukommt.
Differenzialdiagnose des Bluthochdruckes
Authors: Schricker Severin 
Published: April 2019

ZUSAMMENFASSUNGDie arterielle Hypertonie betrifft etwa jeden dritten Menschen. Sie stellt einen der Hauptfaktoren kardiovaskulärer Morbidität und Mortalität dar. Neben der sehr häufigen multifaktoriellen und polygenen primären oder essenziellen Hypertonie existieren verschiedene Ursachen, welche teilweise kausale Behandlungsansätze erlauben und somit eine große prognostische Relevanz besitzen. Das pathophysiologische Verständnis und die Kenntnis möglicher Differenzialdiagnosen sind für einen rationellen Einsatz der Diagnostik unerlässlich. Der vorliegende Artikel fasst diese zusammen und stellt mögliche Vorgehensweisen zur Bewertung verschiedener Formen der sekundären Hypertonie dar.
Estimation of the Humerus Length by its Proximal Segments: A South Indian Anatomical Study
Authors: Prashanth Kasargod Umesh , Pai Mangala Manohar , Murlimanju Bukkambudhi Virupakshamurthy , Prabhu Latha Venkatraya , Prameela Manoor Dass 
Published: April 2019

Introduction To determine the morphometric data of the proximal segments of the humerus in the South Indian population, and to obtain the regression equations that will enable us to predict the whole length of humerus.
Materials and Methods The present study included 166 dried adult human humeri. Their lengths were measured by using the osteometric board. The seven proximal segment lengths of the humeri were assessed by using a digital Vernier caliper (Mitutoyo Corporation 150 mm/6 inch, model number 500-196-20, Kawasaki, Japan).
Results The mean humerus length in the present study was 30.75 ± 2.03 cm on the right side and 30.27 ± 2.28 cm on the left side. The comparison between the right and left sides of the proximal segments of the humerus did not yield statistically significant results (p > 0.05). The present study observed that the relationship between the dimensions of the proximal segments of the humerus and the length of humerus were strong (p = 0.00). The oblique length between the most proximal and distal points over the anatomical neck was the best parameter to predict the length of humerus (the Pearson coefficient was 0.78 for the right side and 0.77 for the left side).
Conclusion The simple regression formulae, which were derived in this study, are helpful in the estimation of the length of the humerus. The formulae can be used in forensic investigations, in which the stature of a person has to be determined and only bone fragments are available. The morphometric data of the present study have implications in archaeological and anthropological studies. The data are enlightening to orthopedicians, when planning reconstructive surgeries of the proximal end of the humerus in the South Indian population.
Anatomical Variation of Hepatic Vascularization: Case Report
Authors: Ruiz Cristiane Regina , Nascimento Sergio Ricardo Rios , Vidsiunas Alex Kors , de Souza Cristiano Cirqueira , Andrades Lilian 
Published: April 2019

AbstractAnatomical variations in the hepatic arteries and in the celiac trunk are important in liver transplants, laparoscopic surgeries, abdominal radiological interventions, and perforating injuries in the abdomen. The goal of the present report is to describe an abdominal vascular variation observed during a routine dissection in the Anatomy Laboratory of the Centro Universitário São Camilo, São Paulo, state of São Paulo, Brazil, in a male individual. The superior mesenteric artery had its origin in the celiac trunk and originated a right accessory hepatic artery that followed its path all the way to the liver. Several authors described variations in the origin and in the path of the hepatic artery and even created specific classifications. The advance of imaging methods that increase the number of studied individuals, without the need of dissection, aids exponentially the quantifying studies that seek to determine a pattern in the variations present in certain populations. The variations of the hepatic artery, as well as of the celiac trunk, have been extensively described in the literature; however, there is no pattern in the number of variations found both in the celiac trunk and in the regular hepatic artery, what leads to a need of description in each case found.