bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two Pseudomonas aeruginosa clonal groups belonging to the PA14 clade are indigenous to the Churince system in Cuatro Ciénegas Coahuila, México
Authors: García‐Ulloa Manuel , Ponce‐Soto Gabriel‐Yaxal , González‐Valdez Abigail , González‐Pedrajo Bertha , Díaz‐Guerrero Miguel , Souza Valeria , Soberón‐Chávez Gloria 
Published: May 2019

SummaryPseudomonas aeruginosa is a widely distributed environmental bacterium but is also an opportunistic pathogen that represents an important health hazard due to its high intrinsic antibiotic resistance and its production of virulence factors. The genetic structure of P. aeruginosa populations using whole genome sequences shows the existence of three clades, one of which (PA7 clade) has a higher genetic diversity. These three clades include clinical and environmental isolates that are very diverse in terms of geographical origins and isolation date. Here, we report the characterization of two distinct clonal P. aeruginosa groups that form a part of the PA14 clade (clade 2) sampled from the Churince system in Cuatro Ciénegas Basin (CCB). One of the clonal groups that we report here was isolated in 2011 (group 2A) and was displaced by the other clonal group (2B) in 2015. Both Churince groups are unable to produce pyoverdine but can produce other virulence‐associated traits. The existence of these unique P. aeruginosa clonal groups in the Churince system is of ecological and evolutionary significance since the microbiota of this site is generally very distinct from other lineages, and this is the first time that a population of P. aeruginosa has been found in CCB.
The relationship between adverse childhood experiences, family functioning, and mental health problems among children and adolescents: a systematic review
Authors: Scully Claudia , McLaughlin Jacintha , Fitzgerald Amanda 
Published: May 2019

This article reports a systematic review of the literature examining the relationship between adverse childhood experiences (ACEs), family functioning (FF) and mental health (MH) problems among children and adolescents. The current review aims to thoroughly investigate the relationship between ACEs, FF and MH, and to synthesise the findings in the literature. Three databases were searched, and a narrative synthesis of the final thirty‐four articles is presented. The results of the systematic review indicate that the association between FF and child/adolescent MH is mixed; ACEs and child/adolescent MH are related; ACEs and FF are related; and demographic factors impact on the association between the three main variables. The literature suggests a strong association between ACEs, child and adolescent MH problems, and FF, and some overlap between these variables is evident. This systematic review highlights the importance of family‐focused care and the value of asking children about their experience of adverse childhood experiences in clinical practice.Practitioner points

The literature suggests a strong relationship between ACEs, FF, and MH problems

FF mediates the relationship between specific ACEs, and child/adolescent MH problems, although further research is warranted

Clinicians working with children and adolescents with MH problems should be mindful of family‐centred care and ask children about their experience of ACEs
The effects of plan payment rates on the market for Medicare Advantage Dual‐Eligible Special Needs Plans
Authors: McGarry Brian E. , Layton Timothy J. , Grabowski David C. 
Published: May 2019

AbstractObjectiveTo determine the effect of higher potential benchmark payment rates on the market for Medicare Advantage (MA) Dual‐Eligible Special Needs Plans (D‐SNPs).Data Sources/Study SettingPublicly available county‐level data from 2009 to 2015 regarding the number of D‐SNPs operating within the county, the enrollment in and five‐star quality of score of these plans, and the benchmark amounts used to determine capitated plan payments.Study DesignThis study exploits the introduction of quality bonus payments to the MA program in 2012, and exogenous geographic variation in the potential size of these bonuses to estimate the effect of benchmark payment increases on the availability, quality, and take‐up of D‐SNPs. We use a difference‐in‐difference estimation approach to compare changes in the market for D‐SNPs in counties eligible for a double bonus to those that are not.Principal FindingsThe doubling of bonuses was associated with a relative 29 percent increase in the number of D‐SNPs offered (P = 0.021) and 0.1‐star increase in the average quality of available D‐SNPs (P = 0.034). No relative increase in overall D‐SNP enrollment was detected.ConclusionsThese findings indicate that larger benchmark payment amounts may influence insurers’ decisions of whether to participate in the D‐SNP market but not dual‐eligibles' decision of whether to enroll in these plans. Future research is needed to inform discussions about whether D‐SNPs are a viable mechanism for integrating benefits for dual eligibles and the degree to which Medicare policies should support their continued growth.
The Effect of Heat Processing on Chemical Composition and Antioxidative Activity of Tea Made from Barley Sprouts and Wheat Sprouts
Authors: Islam Mohammad Zahirul , Yu Deok‐Su , Lee Young‐Tack 
Published: May 2019

AbstractBarley sprouts and wheat sprouts have received much interest as functional foods in many countries. In this study, the effects of heat processing and extraction temperature on the bioactive components and antioxidative properties were examined in barley and wheat sprout teas. Both barley and wheat sprout teas were processed with two different methods (steaming or pan‐roasting). Crude protein was increased, and moisture content was the lowest, in the roasted barley and wheat sprout teas. Total phenolics content and flavonoid contents were significantly higher in the roasted teas than in the steamed teas. Vitamin C content was the highest after an extraction temperature of 55 °C (24.05 mg/mL) in the roasted wheat sprout tea. Both roasted barley and wheat sprout teas exhibited the most antioxidative effects in vitro, demonstrated by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical‐scavenging and nitrite‐scavenging activities. Therefore, the roasting method can be considered an appropriate technique for the production of barley and wheat sprout teas.Practical ApplicationBarley and wheat sprouts have received much attention in recent years as functional food materials in many countries and can be consumed as a form of tea. Heat processing methods such as steaming and roasting were applied and compared to increase the bioactive components and antioxidative activity in barley and wheat sprout teas. We found that roasting showed higher bioactive components and antioxidative activity than steaming in both barley and wheat sprout teas. In addition, wheat sprouts tea showed better bioactive components and antioxidative activity compared with the barley sprout tea.
Enzyme‐Assisted Extraction of Bioactive Compounds from Raspberry (Rubus idaeus L.) Pomace
Authors: Saad N. , Louvet F. , Tarrade S , Meudec E. , Grenier K. , Landolt C. , Ouk T.S. , Bressollier P. 
Published: May 2019

AbstractIndustrial processing of raspberries into juice and jam results in the production of with high content of lipophilic and hydrophilic phytochemicals. Usually considered as waste, raspberry pomace is occasionally cold‐pressed to recover specialty oil. However, the resulting pomace press‐cake (PPC) still contains 30% to 35% of lipophilic compounds, such as essential fatty acids, tocols, phytosterols, and ellagitannins initially present in pomace. In a perspective of sustainable development, we investigate an eco‐friendly process using an aqueous enzyme‐assisted extraction (AEAE) to simultaneously and effectively recover lipophilic compounds and polyphenols from the PPC. The performance of different combinations of carbohydrases and proteases was compared. After selecting the best enzymatic system, a definitive screening design involving six factors was then implemented to optimize the process. Under optimized conditions, 1.2 units of thermostable alkaline protease/100 g PPC, pH 9, 60 °C, and 2 hr hydrolysis, more than 38% of total PPC lipophilic content were recovered in the aqueous medium. The recovery of polyphenols and antioxidant activity was, respectively, 48% and 25% higher than obtained by extraction with methanol/acetone/water mixture. Such an AEAE extract might prove useful in food and nutraceutical applications.Practical ApplicationRaspberry pomace, a food industrial by‐product, is often considered as waste. However, it is a rich source of phytochemicals, such as tocols, polyphenols, and polyunsaturated fatty acids. To overcome the drawbacks of organic solvent use, an enzyme‐assisted extraction process was developed as an eco‐friendly alternative to recover these bioactive compounds. Definitive screening design experimental design was used to enhance polyphenols and lipophilics extraction yields while reducing process costs. This extract is an oil‐in‐water emulsion, with high content in antioxidant phytochemicals, which might have potential for use in nutraceutical applications. Therefore, this green process developed for the valorization of raspberry pomace is considered as a perspective of sustainable development.
Who Shapes the Politics of Expertise? Co‐Production and Authoritative Knowledge in Thailand's Political Forests
Authors: Forsyth Tim 
Published: May 2019

AbstractExpert environmental knowledge has often been described as a governmental rationality that reduces political debate and facilitates state control. In this paper, I argue instead that this line of reasoning simplifies how knowledge gains political authority, especially when expertise is shared and left unchallenged by diverse actors, including those in conflict with each other. Using the framework of co‐production from Science and Technology Studies (STS), I apply this argument to conflicts over the supposed watershed functions of forests in Thailand, where simplified narratives about the impacts of land use on water supply are used as justifications for territorialisation and restrictions on forest land. In particular, I focus on local resistance to the proposed Kaeng Sua Ten dam in northern Thailand in order to demonstrate how protestors have deliberately reproduced formal expertise to empower themselves, but by so doing also reinforcing simplified visions of watershed science and community culture. I argue that exposing the co‐production of authoritative knowledge and visions of social order offer greater opportunities for understanding the role of expertise as a political force than analysing competing assemblages based on oppositions of state‐led expert knowledge and traditional local practices.
Interventions for the prevention of pain associated with the placement of intrauterine contraceptives: An updated review
Authors: Gemzell‐Danielsson Kristina , Jensen Jeffrey T. , Monteiro Ilza , Peers Tina , Rodriguez Maria , Di Spiezio Sardo Attilio , Bahamondes Luis 
Published: May 2019

AbstractA 2013 review found no evidence to support the routine use of pain relief for intrauterine contraceptive (IUC) placement; however, fear of pain with placement continues to be a barrier to use for some women. This narrative review set out to identify (1) new evidence that may support routine use of pain management strategies for IUC placement; (2) procedure‐related approaches that may have a positive impact on the pain experience; and (3) factors that may help healthcare professionals identify women at increased risk of pain with IUC placement. A literature search of the PubMed and Cochrane library databases revealed 550 citations, from which we identified 43 new and pertinent studies for review. Thirteen randomized clinical trials, published since 2012, described reductions in placement‐related pain with administration of oral and local analgesia (oral ketorolac, local analgesia with different lidocaine formulations) and cervical priming when compared with placebo or controls. Four studies suggested that ultrasound guidance, balloon dilation, and a modified placement device may help to minimize the pain experienced with IUC placement. Eight publications suggested that previous cesarean delivery, timing of insertion relative to menstruation, dysmenorrhea, expected pain, baseline anxiety, and size of insertion tube may affect the pain experienced with IUC placement. Oral and local analgesia and cervical priming can be effective in minimizing IUC placement‐related pain when compared with placebo, but routine use remains subject for debate. Predictive factors may help healthcare professionals to identify women at risk of experiencing pain. Targeted use of effective strategies in these women may be a useful approach while research continues in this area.
Exploring the unknown: The effect of resistance to change and attachment on mobile adoption among secondary pre‐service teachers
Authors: Sánchez‐Prieto José Carlos , Huang Fang , Olmos‐Migueláñez Susana , García‐Peñalvo Francisco J. , Teo Timothy 
Published: May 2019

AbstractThis research work intends to make an innovative contribution to the existing literature by studying the predictive effect of two relatively unexplored constructs on the adoption of an emerging technology, such as mobile devices, among a seldom‐studied population in the European context (secondary education preservice teachers). To achieve this goal, a technology acceptance model (TAM)‐based model was designed including the constructs: behavioural intention, perceived usefulness, perceived ease of use, attitude towards use, subjective norm, attachment and resistance to change and it was tested using a sample of 222 Spanish secondary education preservice teachers. The results of the factor analysis evidence the significant effect of resistance to change on the four TAM variables, especially on perceived usefulness and attitude, while the attachment only has a small effect on perceived ease of use. Additionally, the analysis confirms attitude towards the use as the main predictor of the behavioural intention, as well as the influence of the subjective norm on both perceived usefulness and behavioural intention. These findings have important ramifications for the design of teacher training programmes, which are addressed in the discussion, and they also suggest the need to continue studying the effect of new factors on the technology adoption process.
Practitioner NotesWhat is already known about this topic

The TAM model is a widespread theory for the study of the technology adoption with unexplored areas in the educational field.
Despite the didactic potential of mobile devices, they are underused by the teachers which suggest the existence of an adoption problem.
Attachment and resistance to change are two constructs from the second‐order barriers little studied in TAM‐based models applied in the educational field that can provide important information for the development of teacher training initiatives.
What this paper adds

The TAM‐based model developed in this research evidences the influence of the second‐order barriers in the adoption of mobile technologies among secondary preservice teachers.
Resistance to change has an important effect on the intention to use mobile devices in the future teaching practice of secondary preservice teachers.
The effect of the emotional attachment on the adoption of mobile technologies is smaller in utilitarian contexts.
Implications for practice and/or policy

Technology adoption models should pay more attention to unexplored second‐order barriers, especially resistance to change.
The higher education institutions must develop teachers’ training programme more focused on the teaching model built by their students and transmit a new model more positive towards changes emphasizing the possible advantages of incorporating new tools to their future practice.
Drainage reorganization and Laramide tectonics in north‐central New Mexico and downstream effects in the Gulf of Mexico
Authors: Smith Tyson M. , Sundell Kurt E. , Johnston Shelby N. , Guilherme Andrade Carlos N. , Andrea Ross A. , Dickinson Jordan N. , Liu Yiduo A. , Andrew Murphy Michael , Lapen Tom J. , Saylor Joel E. 
Published: May 2019

AbstractThe El Rito and Galisteo depocenters in north‐central New Mexico archive tectonically‐driven Paleogene drainage reorganization, the effects of which influenced sedimentation along the northwestern margin of the Gulf of Mexico. Although separated by ~100 km and lacking depositional chronology for the El Rito Formation, the two aforementioned New Mexican depocenters are commonly considered remnants of a single basin with coeval deposition and shared accommodation mechanism. Detrital zircon U‐Pb maximum depositional ages indicate that the El Rito and Galisteo formations are not coeval. Moreover, stratigraphic thickness trends and mapping relationships indicate different accommodation mechanisms for the Galisteo and El Rito depocenters; tectonically‐induced subsidence versus infilling of incised topography, respectively. The regional unconformity that bounds the base of both the El Rito and Galisteo formations is a correlative surface induced by local tectonic activity and associated drainage reorganization in the early Eocene, and was diachronously buried by northward onlap of fluvial sediments. Detrital zircon distributions in both depocenters indicate increased recycling of Mesozoic strata above the unconformity, but diverge upsection as topographic prominence of local basement‐involved uplifts waned. Sediment capture in these depocenters is coeval with deposition in other externally‐drained Laramide basins. Further, it corresponds to a period of low Laramide province‐derived sediment input and replacement by Appalachian‐sourced sediment along the northwestern margin of the Gulf of Mexico during a basin‐wide transgression. This illustrates the potential effect that pockets of sediment storage within the catchment of a transcontinental drainage system can have over the sedimentary record in the receiving marine basin.
Potentials of C‐C motif chemokine 2–C‐C chemokine receptor type 2 blockers including propagermanium as anticancer agents
Authors: Yumimoto Kanae , Sugiyama Shigeaki , Mimori Koshi , Nakayama Keiichi I. 
Published: May 2019

AbstractInflammation plays an essential role in the development and progression of most cancers. Chemokine C‐C motif chemokine 2 (CCL2) and its receptor C‐C chemokine receptor type 2 (CCR2) constitute a key signaling axis in inflammation that has recently attracted much interest on the basis of evidence showing its association with cancer progression. Propagermanium (3‐oxygermylpropionic acid polymer) is an organogermanium compound that is given for the treatment of hepatitis B in Japan and which inhibits the CCL2‐CCR2 signaling pathway. Herein, we review the importance of the CCL2‐CCR2 axis as a target in cancer treatment as shown by studies in mice and humans with pharmacological agents including propagermanium.
A systematic review and meta‐analysis of systemic exposure associated with molar incisor hypomineralization
Authors: Fatturi Aluhe Lopes , Wambier Leticia Maira , Chibinski Ana Claudia , Assunção Luciana Reichert da Silva , Brancher João Armando , Reis Alessandra , Souza Juliana Feltrin 
Published: May 2019

AbstractObjectiveTo evaluate systemic exposures associated with molar incisor hypomineralization (MIH).MethodsThis systematic review was performed using published observational studies that evaluated the systemic exposures associated with MIH. The sources of articles searched were PubMed, Scopus, Web of Science, LILACS, BBO, Cochrane Library and Grey literature. The risk of bias was analysed according to the Newcastle‐Ottawa Scale for quality assessment. The meta‐analysis was performed considering the exposures during the prenatal, perinatal and postnatal periods using the CMA software.ResultsA total of 4207 articles were identified. Twenty‐nine studies were eligible for inclusion and 27 were included in the meta‐analysis. The studies presented low and moderate risks of bias, except for one that was classified as having a high risk of bias. Maternal illness during pregnancy (OR 1.40; 95% CI 1.18‐1.65, P < 0.0001) and psychological stress (OR = 2.65; 95% CI 1.52‐4.63; P = 0.001) was observed to be significantly associated with higher odds of MIH. During the perinatal period, caesarean delivery (OR = 1.32, 95% CI 1.11‐1.57, P = 0.001) and delivery complications (OR = 2.06; 95% CI 1.47‐2.88, P < 0.0001) were also associated with MIH. In the postnatal period, only respiratory diseases (OR = 1.98; 95% CI 1.45‐2.70, P < 0.0001) and fever (OR = 1.50; 95% CI 1.22‐1.84; P < 0.0001) were associated with higher prevalence of MIH. The evidence was graded as very low quality.ConclusionsMaternal illness, psychological stress, caesarean delivery, delivery complications, respiratory diseases and fever during the first years of a child's life were significantly associated with a higher odds of MIH. However, this should be interpreted with caution, once the primary studies were observational, with serious limitations according to the risk of bias, imprecision, and inconsistency. Further, well‐designed cohort studies are still required.
Social inequality in tooth loss, the mediating role of smoking and alcohol consumption
Authors: Hach Maria , Christensen Lisa B. , Lange Theis , Hvidtfeldt Ulla A. , Danielsen Bo , Diderichsen Finn , Osler Merete , Prescott Eva , Andersen Ingelise 
Published: May 2019

AbstractObjectivesThe objective of the study was to investigate the mediated proportion of smoking and alcohol consumption in the association between education and tooth loss. Further, the objective was, on the additive scale, to decompose the total effect of education on tooth loss into the direct effect of education, the natural indirect effect through smoking and alcohol consumption (differential exposure) and the mediated interaction between education, smoking and alcohol consumption on tooth loss (differential susceptibility).MethodsThe study was based on data from the Social Inequality in Cancer Cohort (SIC); a cohort constructed by seven pooled cohorts. The total study population comprised of 34 975 participants. With the use of natural effects models, we regarded smoking and alcohol consumption as intermediates; we investigated the role of smoking and alcohol consumption in mediating the effect of education on tooth loss.ResultsIn total, 4924 participants had tooth loss defined as <15 teeth present. The results of the analyses, on the additive scale, showed 1202 (95% CI: 623‐1781) additional persons with tooth loss per 10 000 persons among low compared to highly educated men. Among women, the analyses showed 1159 (95% CI: 959‐1359) additional persons with tooth loss per 10 000 persons. The results, on the relative scale, showed that 11% (95% CI: 8%‐15%) of the social inequality in tooth loss was jointly mediated by smoking and alcohol consumption among low‐educated men. Among women with low education, the mediated proportion was 26% (95% CI: 19%‐36%).ConclusionSocial inequality in tooth loss seems partly explained by differential exposure and differential susceptibility to smoking and alcohol consumption.