bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microplegia versus Cardioplexol® in Coronary Artery Bypass Surgery with Minimal Extracorporeal Circulation: Comparison of Two Cardioplegia Concepts
Authors: Koechlin Luca , Rrahmani Bejtush , Gahl Brigitta , Berdajs Denis , Grapow Martin T.R. , Eckstein Friedrich S. , Reuthebuch Oliver 
Published: April 2019

Abstract
Background The aim of this study is to compare the combined use of the Myocardial Protection System and our microplegia (Basel Microplegia Protocol) with Cardioplexol® in coronary artery bypass grafting using the minimal extracorporeal circulation.
Methods The analysis focused on propensity score matched pairs of patients in whom microplegia or Cardioplexol® was used. Primary efficacy endpoints were high-sensitivity cardiac troponin-T on postoperative day 1 and peak values during hospitalization. Furthermore, we assessed creatine kinase and creatinine kinase-myocardial type, as well as safety endpoints.
Results A total of 56 patients who received microplegia and 155 patients who received Cardioplexol® were included. The use of the microplegia was associated with significantly lower geometric mean (confidence interval) peak values of high-sensitivity cardiac troponin-T (233 ng/L [194–280 ng/L] vs. 362 ng/L [315–416 ng/L]; p = 0.001), creatinine kinase (539 U/L [458–633 U/L] vs. 719 U/L [645–801 U/L]; p = 0.011), and creatinine kinase-myocardial type (13.8 µg/L [9.6–19.9 µg/L] vs. 21.6 µg/L [18.9–24.6 µg/L]; p = 0.026), and a shorter length of stay on the intensive care unit (1.5 days [1.2–1.8 days] vs. 1.9 days [1.7–2.1 days]; p = 0.011). Major adverse cardiac and cerebrovascular events occurred with roughly equal frequency (1.8 vs. 5.2%; p = 0.331).
Conclusions The use of the Basel Microplegia Protocol was associated with lower peak values of high-sensitivity cardiac troponin-T, creatinine kinase, and creatinine kinase-myocardial type and with a shorter length of stay on the intensive care unit, as compared with the use of Cardioplexol® in isolated coronary artery bypass surgery using minimal extracorporeal circulation.
Mechanism of neoagarotetraose protects against intense exercise-induced liver injury based on molecular ecological network analysis
Authors: Chen Xin , Yu Jiahong , Xue Changhu , Wang Yuming , Tang Qingjuan , Mao Xiangzhao 
Published: April 2019

ABSTRACT
Here we have explored the effect of neoagarotetraose (NAT) on liver injury caused by intense exercise. Our results showed that NAT treatment obviously decreased liver weight (p &lt; 0.01), improved the liver morphological structure, decreased ALT level (p &lt; 0.05) and endotoxin (LPS) (p &lt; 0.01). In addition, NAT could regulate bile acid profiles in feces and serum of mice, which indicated the potential of liver function, suggesting that NAT was effective to relieve intense exercise-induced liver injury. NAT could regulate the expression of colon genes. NAT tended to alter the microbial composition of mice under intense exercise. We uncovered the network interactions between liver traits and microbial communities in NAT treatment mice. Interestingly, our data indicated that intense exercise-induced liver injury may be related to Clostridiales. In summary, these results demonstrated that NAT relieved liver injury induced by intense exercise may be related to gut microbiota.
Bacterial communication through membrane vesicles
Authors: Toyofuku Masanori 
Published: April 2019

ABSTRACT
Bacteria can communicate through diffusible signaling molecules that are perceived by cognate receptors. It is now well established that bacterial communication regulates hundreds of genes. Hydrophobic molecules which do not diffuse in aqueous environments alone have been identified in bacterial communication, that raised the question on how these molecules are transported between cells and trigger gene expressions. Recent studies show that these hydrophobic signaling molecules, including a long-chain N-acyl homoserine lactone signal produced in Paracoccus denitrificans, are carried by membrane vesicles (MVs). MVs were thought to be formed only through the blebbing of the cell membrane, but new findings in Pseudomonas aeruginosa and Bacillus subtilis revealed that different types of MVs can be formed through explosive cell lysis or bubbling cell death, which findings have certain implications on our view of bacterial interactions.
Exploring the entanglement of free spin-

, spin-1 and spin-2 fields *
Authors: Yang Zhi , Hung Ling-Yan 
Published: April 2019

Abstract
In this study, we explore the entanglement of free spin-

, spin-1, and spin-2 fields. We start with an example involving Majorana fields in 1+1 and 2+1 dimensions. Subsequently, we perform the Bogoliubov transformation and express the vacuum state with a particle pair state in the configuration space, which is used to calculate the entropy. This clearly demonstrates that the entanglement entropy originates from the particles across the boundary. Finally, we generalize this method to free spin-1 and spin-2 fields. These higher free massless spin fields have well-known complications owing to gauge redundancy. We deal with the redundancy by gauge-fixing in the light-cone gauge. We show that this gauge provides a natural tensor product structure in the Hilbert space, while surrendering explicit Lorentz invariance. We also use the Bogoliubov transformation to calculate the entropy. The area law emerges naturally by this method.
Quark-antiquark scattering phase shift and meson spectral function in pion superfluid *
Authors: Xia Tao , Hu Jin , Mao Shijun 
Published: April 2019

Abstract
We study the quark-antiquark scattering phase shift and meson spectral function in the pion superfluid described by the Nambu-Jona-Lasinio model. Meson mixing in the pion superfluid dramatically changes the full scattering phase shift and significantly broadens the spectral function of some collective modes.
Elliptic flow of transported and produced protons in Au+Au collisions with the UrQMD model *
Authors: Tu Biao , Shi Shusu , Liu Feng 
Published: April 2019

Abstract
Within the framework of the UrQMD model, by tracing the number of initial quarks in protons, we study the elliptic flow of protons with 3, 2, 1, 0 initial quarks and anti-protons in Au+Au collisions at

= 7.7, 11.5, 39, 200 GeV. The difference of elliptic flow between protons with 2, 1, 0 initial quarks and anti-protons is smaller than 0, or consistent with 0, respectively. The difference of elliptic flow between transported protons (with 3 initial quarks) and anti-protons is larger than 0 at 7.7, 11.5 and 39 GeV. This is in good agreement with the STAR results at 7.7 and 11.5 GeV, but overestimates the STAR results at 39 GeV. The yield of transported protons with 3 initial quarks is smaller than of protons with 2 and 1 initial quarks, and

of all protons is much smaller than the STAR results. The observation of the difference of elliptic flow between transported protons and anti-protons in the UrQMD model partly explains the

difference between protons and anti-protons observed in the Beam Energy Scan program at the Relativistic Heavy Ion Collider (RHIC).
Theoretical investigation of the antimagnetic rotation in 104Pd *
Authors: Zhang Zhen-Hua 
Published: April 2019

Abstract
The particle-number-conserving method based on the cranked shell model is used to investigate the antimagnetic rotation band in 104Pd. The experimental moments of inertia and reduced B(E2) transition probabilities are reproduced well. The J
(2)/B(E2) ratios are also discussed. The occupation probability of each orbital close to the Fermi surface and the contribution of each major shell to the total angular momentum alignment as function of rotational frequency are analyzed. The backbending mechanism of the ground state band in 104Pd is understood clearly and the configuration of the antimagnetic rotation after backbending is clarified. In addition, the crossing of a four quasiparticle state with this antimagnetic rotation band is also predicted. By examining the closing of the angular momenta of four proton holes towards the neutron angular momentum, the " two-shears-like” mechanism for this antimagnetic rotation is investigated and two stages of antimagnetic rotation in 104Pd are clearly seen.
Precise assembly and joining of silver nanowires in three dimensions for highly conductive composite structures
Authors: Liu Ying , Xiong Wei , Li Da Wei , Lu Yao , Huang Xi , Liu Huan , Fan Li Sha , Jiang Lan , Silvain Jean-François , Lu Yong Feng 
Published: April 2019

Abstract
Three-dimensional (3D) electrically conductive micro/nanostructures are now a key component in a broad range of research and industry fields. In this work, a novel method is developed to realize metallic 3D micro/nanostructures with silver-thiol-acrylate composites via two-photon polymerization followed by femtosecond laser nanojoining. Complex 3D micro/nanoscale conductive structures have been successfully fabricated with ∼200 nm resolution. The loading of silver nanowires (AgNWs) and joining of junctions successfully enhance the electrical conductivity of the composites from insulating to 92.9 S m−1 at room temperature. Moreover, for the first time, a reversible switching to a higher conductivity is observed, up to ∼105 S m−1 at 523 K. The temperature-dependent conductivity of the composite is analyzed following the variable range hopping and thermal activation models. The nanomaterial assembly and joining method demonstrated in this study pave a way towards a wide range of device applications, including 3D electronics, sensors, memristors, micro/nanoelectromechanical systems, and biomedical devices, etc.
The impact of Methodism
Authors: Abraham William J. 
Published: April 2019

Abstract
‘The impact of Methodism’ considers Methodism’s impact on and contribution to social movements, politics, education, and healthcare. Social movements that were deeply influenced by Methodism include the abolition of slavery in the 19th century and the Temperance Movement in the 20th century. The Methodist tradition has always encouraged diversity of judgement in the political arena and Methodists can be found on both the conservative and progressive wings of politics. One of the most important expressions of social holiness in Methodism shows up in its role in education. Methodists founded numerous successful schools and universities around the world. Methodism has also had an impact on popular and high culture.
The Impact of the Revised WIC Food Package on Maternal Nutrition During Pregnancy and Postpartum
Authors: Hamad Rita , Batra Akansha , Karasek Deborah , LeWinn Kaja Z , Bush Nicole R , Davis Robert L , Tylavsky Frances A 
Published: April 2019

Abstract
The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides nutritional support for pregnant and postpartum women and young children. The typical food package provided to recipient families was revised in October 2009 to include more whole grains, fruits, vegetables, and low-fat milk. Little is known about whether these revisions improved nutrition among women during this critical period of the life course. We conducted a quasiexperimental difference-in-differences analysis, comparing WIC recipients (“treatment” group) before and after the WIC policy change, while accounting for temporal trends among nonrecipients (“control” group). We examined nutritional outcomes among a cohort of 1,454 women recruited during pregnancy in 2006–2011 in Memphis and surrounding Shelby County, Tennessee. We found improvements in several measures of dietary quality and nutrient intake during pregnancy, although these did not persist into the postpartum period. Results were robust to numerous sensitivity analyses. At a time when federal WIC funding is threatened, this study provides some of the first evidence of the benefits of recent WIC revisions among low-income women.
Identification of disease-associated loci using machine learning for genotype and network data integration
Authors: Leal Luis G , David Alessia , Jarvelin Marjo-Riita , Sebert Sylvain , Männikkö Minna , Karhunen Ville , Seaby Eleanor , Hoggart Clive , Sternberg Michael J E 
Published: April 2019

AbstractMotivationIntegration of different omics data could markedly help to identify biological signatures, understand the missing heritability of complex diseases and ultimately achieve personalized medicine. Standard regression models used in Genome-Wide Association Studies (GWAS) identify loci with a strong effect size, whereas GWAS meta-analyses are often needed to capture weak loci contributing to the missing heritability. Development of novel machine learning algorithms for merging genotype data with other omics data is highly needed as it could enhance the prioritization of weak loci.ResultsWe developed cNMTF (corrected non-negative matrix tri-factorization), an integrative algorithm based on clustering techniques of biological data. This method assesses the inter-relatedness between genotypes, phenotypes, the damaging effect of the variants and gene networks in order to identify loci-trait associations. cNMTF was used to prioritize genes associated with lipid traits in two population cohorts. We replicated 129 genes reported in GWAS world-wide and provided evidence that supports 85% of our findings (226 out of 265 genes), including recent associations in literature (NLGN1), regulators of lipid metabolism (DAB1) and pleiotropic genes for lipid traits (CARM1). Moreover, cNMTF performed efficiently against strong population structures by accounting for the individuals’ ancestry. As the method is flexible in the incorporation of diverse omics data sources, it can be easily adapted to the user’s research needs.Availability and implementationAn R package (cnmtf) is available at https://lgl15.github.io/cnmtf_web/index.html.Supplementary informationSupplementary data are available at Bioinformatics online.
Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse
Authors: Hadji-Turdeghal Katra , Andreasen Laura , Hagen Christian M , Ahlberg Gustav , Ghouse Jonas , Bækvad-Hansen Marie , Bybjerg-Grauholm Jonas , Hougaard David M , Hedley Paula , Haunsø Stig , Svendsen Jesper H , Kanters Jørgen K , Jepps Thomas A , Skov Morten W , Christiansen Michael , Olesen Morten S 
Published: April 2019

AbstractAimsSyncope is a common condition associated with frequent hospitalization or visits to the emergency department. Family aggregation and twin studies have shown that syncope has a heritable component. We investigated whether common genetic variants predispose to syncope and collapse.Methods and resultsWe used genome-wide association data on syncope on 408 961 individuals with European ancestry from the UK Biobank study. In a replication study, we used the Integrative Psychiatric Research Consortium (iPSYCH) cohort (n = 86 189), to investigate the risk of incident syncope stratified by genotype carrier status. We report on a genome-wide significant locus located on chromosome 2q32.1 [odds ratio = 1.13, 95% confidence interval (CI) 1.10–1.17, P = 5.8 × 10−15], with lead single nucleotide polymorphism rs12465214 in proximity to the gene zinc finger protein 804a (ZNF804A). This association was also shown in the iPSYCH cohort, where homozygous carriers of the C allele conferred an increased hazard ratio (1.30, 95% CI 1.15–1.46, P = 1.68 × 10−5) of incident syncope. Quantitative polymerase chain reaction analysis showed ZNF804A to be expressed most abundantly in brain tissue.ConclusionWe identified a genome-wide significant locus (rs12465214) associated with syncope and collapse. The association was replicated in an independent cohort. This is the first genome-wide association study to associate a locus with syncope and collapse.
Glutathione Serum Levels and Rate of Multimorbidity Development in Older Adults
Authors: Pérez Laura M , Hooshmand Babak , Mangialasche Francesca , Mecocci Patrizia , Smith A David , Refsum Helga , Inzitari Marco , Fratiglioni Laura , Rizzuto Debora , Calderón-Larrañaga Amaia 
Published: April 2019

Abstract
We aimed to investigate the association between baseline levels of total serum glutathione (tGSH) and rate of chronic disease accumulation over time. The study population (n = 2,596) was derived from a population-based longitudinal study on ≥60-year-olds living in Stockholm. Participants were clinically assessed at baseline, 3- and 6-year follow-ups. Multimorbidity was measured as the number of chronic conditions from a previously built list of 60 diseases. Linear mixed models were applied to analyze the association between baseline tGSH levels and the rate of multimorbidity development over 6 years. We found that at baseline, participants with ≥4 diseases had lower tGSH levels than participants with no chronic conditions (3.3 vs 3.6 µmol/L; p &lt; .001). At follow-up, baseline levels of tGSH were inversely associated with the rate of multimorbidity development (β * time: −0.044, p &lt; .001) after adjusting for age, sex, education, levels of serum creatinine, C-reactive protein, albumin, body mass index, smoking, and time of dropout or death. In conclusion, serum levels of tGSH are inversely associated with multimorbidity development; the association exists above and beyond the link between tGSH and specific chronic conditions. Our findings support the hypothesis that tGSH is a biomarker of multisystem dysregulation that eventually leads to multimorbidity.
Cultural Relevance Reduces the Enhanced Neural Processing of Positively Valenced Information in Older Adults
Authors: Gong Xianmin , Fung Helene H , Zeng Ginger Qinghong , Tse Chun-Yu 
Published: April 2019

Abstract

Objectives
This study investigated (a) whether the age-related enhancement in processing positive relative to negative emotional information happened at the early and/or late processing stages and (b) if the age-related positivity effect was modulated by cultural relevance using event-related brain potential (ERP).

Methods
Seventeen younger and 19 older Chinese adults judged the emotional valence of Chinese and Western pictures while electroencephalogram (EEG) was recorded and analyzed by temporospatial principal component analysis to dissociate the processing stages.

Results
(a) Larger N100 for negative than positive pictures was observed in younger, but not older adults, while older but not younger adults showed larger late anterior P300 for positive than negative pictures. (b) Older adults showed larger early posterior P300 for positive than negative Western pictures, but not culturally relevant Chinese pictures; such modulation effect by cultural relevance was absent in younger adults.

Discussion
These findings suggest an age-related decrease in sensitivity to negative information in the earlier stage and an age-related increase in sensitivity to positive information in the later stage of cognitive processing. This supports a dual-route model of the age-related positivity effect. Moreover, the age-related positivity effect is more evident for stimuli with less cultural relevance.
Glycoengineering of HEK293 cells to produce high-mannose-type N-glycan structures
Authors: Ren Wei-Wei , Jin Ze-Cheng , Dong Weijie , Kitajima Toshihiko , Gao Xiao-Dong , Fujita Morihisa 
Published: April 2019

Abstract
Therapeutic proteins are a developing part of the modern biopharmaceutical industry, providing novel therapies to intractable diseases including cancers and autoimmune diseases. The human embryonic kidney 293 (HEK293) cell line has been widely used to produce recombinant proteins in both basic science and industry. The heterogeneity of glycan structures is one of the most challenging issues in the production of therapeutic proteins. Previously, we knocked out genes encoding α1,2-mannosidase-Is, MAN1A1, MAN1A2 and MAN1B1, in HEK293 cells, establishing a triple-knockout (T-KO) cell line, which produced recombinant protein with mainly high-mannose-type N-glycans. Here, we further knocked out MAN1C1 and MGAT1 encoding another Golgi α1,2-mannosidase-I and N-acetylglucosaminyltransferase-I, respectively, based on the T-KO cells. Two recombinant proteins, lysosomal acid lipase (LIPA) and immunoglobulin G1 (IgG1), were expressed in the quadruple-KO (QD-KO) and quintuple-KO (QT-KO) cell lines. Glycan structural analysis revealed that all the hybrid-type and complex-type N-glycans were eliminated, and only the high-mannose-type N-glycans were detected among the recombinant proteins prepared from the QD-KO and QT-KO cells. Overexpression of the oncogenes MYC and MYCN recovered the slow growth in QD-KO and QT-KO without changing the glycan structures. Our results suggest that these cell lines could be suitable platforms to produce homogeneous therapeutic proteins.
Emerging Cancer Survival Trends, Disparities, and Priorities in Adolescents and Young Adults: A California Cancer Registry-Based Study
Authors: Moke Diana J , Tsai Kaiya , Hamilton Ann S , Hwang Amie , Liu Lihua , Freyer David R , Deapen Dennis 
Published: April 2019

Abstract

Background
Although landmark studies in the 1990s demonstrated that adolescents and young adults (AYAs, ages 15–39 years) with cancer had lower survival improvement compared to other ages, therapeutic advances warrant reappraisal of those observations. We utilized more recent data to study site-specific AYA survival trends and disparities and gain a more contemporary understanding of this problem.

Methods
Using California Cancer Registry data from 1988 to 2014, we calculated 1) 5-year overall survival improvement for AYAs compared to other age groups; 2) hazard ratios (HRs) of death for AYAs comparing 2001–2014 with 1988–2000 stratified by site, stage, sex, age group, race and ethnicity, and socioeconomic status (SES); and 3) site-specific adjusted HRs (aHRs) for AYA risk groups and interaction analyses by time period.

Results
For all cancers combined, AYAs demonstrated survival improvement that exceeded all other age groups, largely due to reduced mortality in human immunodeficiency virus and acquired immunodeficiency syndrome-related cancers. The strongest predictor of death was cancer stage (aHR = 6.32 for distant vs localized, 95% confidence interval [CI] = 6.20 to 6.45). The aHR of death was statistically significantly higher for blacks (1.46, 95% CI = 1.42 to 1.50), Asian and Pacific Islanders (1.12, 95% CI = 1.09 to 1.15), and Latino whites (1.06, 95% CI = 1.04 to 1.08) compared to non-Latino whites, and was statistically significantly higher for low SES compared to high (1.31, 95% CI = 1.29 to 1.34). Survival disparities by stage, race and ethnicity, and SES worsened over time.

Conclusions
For AYAs in aggregate, the historical cancer survival improvement gap has been closed. However, the growing survival disparities in AYA subsets reported here, including advanced stage disease, racial and ethnic minorities, and low SES, highlight new priorities in need of increased attention, including inequities in cancer care and delivery within this vulnerable population.