bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of sodium metasilicate on the early-age hydration and setting behavior of alkali-activated common cements containing slag
Authors: Kryvenko P , Rudenko I , Gelevera O , Konstantynovskyi O 
Published: December 2024

Abstract
The ways to keep under regulation the early-age hydration and setting behavior of the common cements containing slag per EN 197-1:2011 and activated with sodium metasilicate were discovered and the results are discussed. The alkaline activation of these cements using sodium metasilicate is one of the ways to escape the strength loss in the cement systems with blast-furnace slag content of 5… 95 %. However, these cements have too short setting times. This requires finding ways to regulate the structure formation. The aggregate states of sodium metasilicate, thes We were: a liquid state (solution) and a solid state (powder) as well as the admixture-surfactant have been chosen as factors of influence to regulate setting times. The results of the study showed that the use of sodium metasilicate in the liquid state, on contrary to the solid state, provided additional intensification of the structure formation. The acceleration of the structure formation processes was accompanied by the formation of high early (1 day) compressive strength of 43… 54 MPa, associated with an extremely quick setting time of 1… 8 min. The sodium lignosulphonate admixture could be of help: its addition in a quantity of 4 % can retard the structure formation processes to the required ranges, not depending upon the aggregate state of sodium metasilicate. The resulting alkali-activated common cements containing slag are characteristic of the early (1 day) compressive strength of 33… 48 MPa and initial setting time of 38… 50 min.
Sustainable web API evolution: Forecasting software development effort
Authors: Ye Saukh S , Puchko T V 
Published: December 2024

Abstract
The study delves into the main stages of the life cycle of software systems, emphasizing the integral role of web APIs within this framework. Notably, we focus on analyzing the structural components of development costs associated with these systems. Our findings reveal a considerable portion of the costs dedicated to sustaining the robust development of the software system. This underscores the importance of forecasting the intensity of various types of requests for system changes, enabling the timely fulfillment of customer requirements and accurate estimation of investment costs throughout the software system’s life cycle. To address this need, we propose a method for forecasting costs to support the sustainable development of a software system. This method relies on a hierarchical algorithmic clustering approach applied to retrospective weekly schedules of client requests for system changes. The clustering process is executed separately for each type of change, yielding distinct graphs. Representative graphs within the obtained clusters serve as key elements in predictive calculations. Determining a representative graph for each cluster, along with the corresponding cluster size, enables prediction by adding representative graphs in proportion to the cluster size. Maintaining the correct proportionality is achieved through the implementation of a greedy algorithm. The application of the developed forecasting method to support the sustainable development of the software system is illustrated using experimental data. This approach not only caters to current customer requirements but also ensures a comprehensive estimation of investment costs, offering valuable insights for optimizing the software system’s life cycle.
Determination of operating parameters of accumulative electric heating systems
Authors: Kolienko A G , Ahmednabiev R M , Gupalo O V , Demchenko O V , Hukasian O M 
Published: December 2024

Abstract
The article presents the results of research aimed at determining the parameters and characteristics of storage heating systems, justifying the possibility of using heat accumulators to increase the efficient use of energy that is generated, including from renewable sources. The virtuality, frequency and significant dependence on natural conditions and climate of renewable energy sources, as well as the need to optimize their installed capacity, leads to the need to use energy storage installations. The presence of efficient energy batteries is a prerequisite for modern efficient energy and heat supply systems. The methodology of the work is based on our own theoretical and experimental studies, which provide practical recommendations for the arrangement of energy accumulators obtained using renewable heat sources. This is especially relevant for Ukraine during the period of active military operations on its territory, the destruction of traditional energy sources and a shortage of generating capacity. Recommendations have been developed for the design of heat accumulators for heating systems of residential and public buildings. Their effectiveness has been assessed under conditions of limited use of fossil fuels and the use of hybrid energy sources. Scientific and practical results of the work make it possible to carry out low-cost reconstruction of heating systems for the introduction of storage systems using electrical energy, the source of which is wind and solar energy. Such developments are becoming particularly relevant in Ukraine, taking into account the requirements for ensuring the stability and efficiency of infrastructure facilities in war conditions.
Harmful, Expensive and Criminogenic: The Case for Abolishing Detention and Training Orders in England and Wales
Authors: Hampson Kathy , Day Anne-Marie 
Published: December 2024

Abstract
Children who offend generally receive community sentences, to help them overcome difficulties whilst naturally addressing offending behaviour; however, children can also receive custody, which has a plethora of known harms. Children’s rights instruments call for custody to be reserved as a ‘last resort’ response to extremely serious offending. However, in England and Wales this is demonstrably not the case, meaning that children still receive short custody orders (in the form of a Detention and Training Order [DTO]) for relatively minor offences. We argue that legislative change should abolish the DTO because of the harms custody wreaks, from several different perspectives (their rights, moral treatment of children, sentencing guidelines, practical and financial considerations), to leave the use of custody only possible for very serious offending, and thus reaching the goal of ‘last resort’.
Quantifying multilabeled brain cells in the whole prefrontal cortex reveals reduced inhibitory and a subtype of excitatory neuronal marker expression in serotonin transporter knockout rats
Authors: Guo Chao Ciu-Gwok , Xu Yifan , Shan Ling , Foka Kyriaki , Memoli Simone , Mulveen Calum , Gijsbrechts Barend , Verheij Michel M , Homberg Judith R 
Published: December 2024

Abstract
The prefrontal cortex regulates emotions and is influenced by serotonin. Rodents lacking the serotonin transporter (5-HTT) show increased anxiety and changes in excitatory and inhibitory cell markers in the prefrontal cortex. However, these observations are constrained by limitations in brain representation and cell segmentation, as standard immunohistochemistry is inadequate to consider volume variations in regions of interest. We utilized the deep learning network of the StarDist method in combination with novel open-source methods for automated cell counts in a wide range of prefrontal cortex subregions. We found that 5-HTT knockout rats displayed increased anxiety and diminished relative numbers of subclass excitatory VGluT2+ and activated ΔFosB+ cells in the infralimbic and prelimbic cortices and of inhibitory GAD67+ cells in the prelimbic cortex. Anxiety levels and ΔFosB cell counts were positively correlated in wild-type, but not in knockout, rats. In conclusion, we present a novel method to quantify whole brain subregions of multilabeled cells in animal models and demonstrate reduced excitatory and inhibitory neuronal marker expression in prefrontal cortex subregions of 5-HTT knockout rats.
A systematic review of parent–child communication in pediatric asthma
Authors: Koskela-Staples Natalie C , Moorman Erin L , Jackson Emily , Fisher Carla L , Fedele David A 
Published: December 2024

Abstract

Objective
Parent–child communication is integral to pediatric asthma management. This review evaluates parent–child communication among youth with asthma and their caregivers. It aims to characterize the type of communication according to a unifying framework (Murphy, L. K., Murray, C. B., & Compas, B. E., Guest Editors: Cynthia A. Gerhardt, Cynthia A. Berg, Deborah J. Wiebe and Grayson N. Holmbeck (2017). Topical review: Integrating findings on direct observation of family communication in studies comparing pediatric chronic illness and typically developing samples. Journal of Pediatric Psychology, 42, 85–94. https://doi.org/10.1093/jpepsy/jsw051), assess sociodemographic factors associated with communication, and examine the relationship between parent–child communication and youth psychosocial and health-related outcomes.

Methods
A systematic literature search was conducted using PubMed, PsycINFO, CINAHL, Web of Science, Cochrane Library, and Embase databases (June 2021; updated May 2024). Included studies reported original, peer-reviewed research on the relationship between parent–child communication and youth psychosocial or health outcomes among pediatric patients (mean age &lt;18 years) with asthma and their primary caregiver(s). Study quality was evaluated using the Study Quality Assessment Tools of the NHLBI.

Results
Sixty-six articles were included with data from 5,373 youth with asthma. Studies assessed both positive (warm and structured) and negative (hostile/intrusive and withdrawn) communication. Most studies used questionnaires and cross-sectional designs. Associations between sociodemographic and communication variables were largely nonsignificant. Greater positive and less negative communication was associated with better youth psychosocial and asthma outcomes overall.

Conclusion
Parent–child communication may be an important target for interventions aimed at improving youth outcomes. More research is needed to develop communication-focused interventions that aim to enhance parents’ and youths’ communication skills (i.e., increase their use of positive communication approaches and/or reduce their use of negative communication approaches) and evaluate their impact on youth outcomes. Future research should also use more discussion tasks and longitudinal designs.
Online Screening and Virtual Patient Education for Hereditary Cancer Risk Assessment and Testing
Authors: Waldman Richard N. , DeFrancesco Mark S. , Feltz John P. , Welling Daniel S. , Neiman Wade A. , Pearlstone Melissa M. , Marraccini Christine A. , Karanik Dana , Mielcarski Elaine , Schneider Logan , Lenz Lauren , Smith Edith C. , Taber Katherine Johansen , Adkins Royce T. 
Published: December 2024

OBJECTIVE:
To use online screening and virtual patient education tools to improve the provision of hereditary cancer risk assessment.

METHODS:
We conducted a prospective, single-arm study in which clinicians at five U.S. community obstetrics and gynecology practices underwent an 8-week observation followed by 3−4 weeks of training on online patient screening and virtual patient education (prerecorded video with or without a genetic counselor phone call) for genetic testing–eligible patients. After a 4-week practice period, hereditary cancer risk assessment and patient education metrics were collected at 8 weeks and compared with preintervention metrics using univariate conditional logistic regression models stratified by site. The primary outcome was the change in genetic testing completion rate. Clinicians and patients were invited to complete a satisfaction survey.

RESULTS:
A total of 5,795 and 5,135 patients were seen before and after the intervention, respectively. The proportion of screened patients meeting testing guidelines increased from 21.6% before the intervention to 28.2% after the intervention (odds ratio [OR] 1.36, 95% CI, 1.26–1.47, P<.001). Guideline-eligible patients were significantly more likely to be offered genetic testing (59.1% vs 89.1%, OR 2.06, 95% CI, 1.87–2.27, P<.001), to submit a sample (32.9% vs 45.0%, OR 1.49, 95% CI, 1.27–1.74, P<.001), and to complete testing (16.0% vs 34.2%, OR 2.38, 95% CI, 2.00–2.83, P<.001). Most clinicians agreed or strongly agreed that the screening tool improved the identification of patients meeting hereditary cancer risk assessment guidelines (92.1%), saved time (64.9%), and was easy to incorporate (68.4%) and that patient education improved their ability to deliver hereditary cancer risk assessment standard of care (84.2%). Most patients agreed or strongly agreed that virtual education helped them understand the purpose (91.7%) and implications (92.6%) of genetic testing.

CONCLUSION:
A guideline-based online patient screening tool and virtual patient education were well received. The online tool enabled identification of significantly more guideline-eligible candidates for hereditary cancer risk assessment, and education improved patients' genetic literacy. Together, these tools ultimately improved the genetic testing completion rate.
Assessing the value of liver fibrosis scores in hypertension: findings from a cross-sectional study
Authors: Xiong Shengjun , Li Wenhang , Yin Shizhang , Deng Wanshu , Zhao Yuanhui , Wang Pengbo , Guo Xiaofan , Sun Yingxian , Yang Hongmei 
Published: December 2024

Background and purpose:
Hypertension is the most significant modifiable risk factor for all-cause morbidity worldwide and is associated with an increased risk of cardiovascular disease. To alleviate the public health burden of hypertension, early identification of risk factors and preventive strategies is vital. Liver fibrosis scores (LFSs), which serve as non-invasive alternatives to liver biopsy, are commonly used to assess liver disease. Growing evidence demonstrated that liver disease may contribute to various systemic adverse effects, such as inflammation and activation of the renin-angiotensin-aldosterone system and the sympathetic nervous system, play a critical role in the pathophysiology of hypertension. This study aims to explore the relationship between LFSs and hypertension.

Methods:
A total of 11,503 participants from the Northeast China Rural Cardiovascular Health Study, which is a large prospective cross-sectional research consisting of a community all coming from rural areas, were included in this study. Four different LFSs were utilized: the aspartate aminotransferase (AST)/platelet ratio index (APRI); the BARD score (incorporating body mass index [BMI], AST/alanine aminotransferase [ALT] ratio, and diabetes status); the BAAT score (BMI, age, ALT, and triglycerides [TGs]); and the fibrosis-4 (FIB-4) index. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CI). Subgroup analysis was conducted to examine associations between LFSs and hypertension across different stratifications, while restricted cubic spline analysis demonstrated the linear correlation between LFSs and hypertension risk. The C statistic, net reclassification index (NRI), and integrated discrimination improvement (IDI) were calculated to evaluate the impact of each LFS on hypertension risk prediction.

Results:
Baseline data identified that all four LFSs were higher among participants with hypertension. In multivariate logistic regression analysis, the OR for hypertension was as follows: 2.34 (95% CI: 1.95–2.81) for FIB-4, 1.34 (95% CI: 1.17–1.53) for the BARD score, 1.21 (95% CI: 1.03–1.43) for APRI, and last 1.21 (95% CI: 1.00–1.47) for the BAAT score, comparing high and low levels of each LFS. Adding LFSs to the original risk prediction model improved its predictive accuracy, with higher C-statistics and positive NRI and IDI values, indicating a significant enhancement in risk prediction for hypertension.

Conclusion:
This study demonstrates that LFSs are related to hypertension in individuals aged 35 and older in rural northeastern China.
Prognostic value of red blood cell distribution width-to-albumin ratio in patients with stable coronary artery disease stratified by glucose metabolic status: a prospective cohort study
Authors: Liu Huihui , Guo Yuanlin , Zhu Chenggang , Wu Naqiong , Gao Ying , Xu Ruixia , Dong Qian , Qian Jie , Li Jian-Jun 
Published: December 2024

Background and purpose:
The red blood cell distribution width-to-albumin ratio (RAR) has emerged as a prognostic marker in various cardiovascular conditions. This investigated the association between RAR and cardiovascular outcomes in patients with stable coronary artery disease (SCAD), with a focus on variations across glucose metabolism status, a relationship not previously explored.

Methods:
A cohort of 4,266 consecutive SCAD patients was recruited and stratified into quartiles based on RAR levels. All participants were regularly monitored for major adverse cardiovascular events (MACEs), encompassing cardiovascular mortality, non-fatal myocardial infarction, and ischemic stroke. Cox regression analyses and glucose metabolic stratification were employed to assess the correlation between RAR and MACEs.

Results:
Over a mean follow-up of 52.77 ± 20.13 months, 287 MACEs were documented. Multivariate Cox regression analysis revealed a significant association between RAR and MACEs, both as a continuous variable and across quartiles. Patients in the third (Q3) and fourth (Q4) RAR quartiles exhibited a 1.92-fold (95% confidence interval [95% CI]: 1.05–3.52) and 2.01-fold (95% CI: 1.10–3.69) increased risk of MACEs, respectively, compared to those in the first quartile (Q1). Stratified analysis by glucose metabolic status further demonstrated that the correlation between higher RAR and MACEs was primarily observed among individuals with abnormal glucose regulation (AGR), particularly in those with diabetes mellitus.

Conclusions:
RAR served as a robust predictor of MACE risk in SCAD patients, with enhanced prognostic significance in individuals with AGR, especially in those with diabetes mellitus. These findings highlight RAR’s potential as a simple and effective risk stratification tool for high-risk SCAD patients.
In Vivo and Ex Vivo Evaluation of a Novel Method for Topical Delivery of Macromolecules Through the Stratum Corneum for Cosmetic Applications
Authors: Moradi Amir , Bhatia Ashish C. , Behr Kathleen , Napekoski Karl , Foldvari Marianna 
Published: December 2024

BACKGROUND
Effective topical delivery of large/charged molecules into skin has always been challenging. Chemical penetration enhancers, organic substances that increase permeability of skin, have been in use for decades with variable success. One application of enhancers involves multilamellar vesicles composed of submicron emulsion droplets and micelles surrounded by concentric phospholipid bilayers.

OBJECTIVE
This report introduces the next generation of multilamellar vesicles, termed Tiered-Release Vesicles (TRVs), as a new platform for topical delivery of macromolecules such as peptides and hyaluronic acid (HA).

METHODS
Fluorescently labeled peptides and HA, diffusion cells, and confocal microscopy were employed to assess the penetration efficiency of macromolecules in TRV formulations using an ex vivo human skin model. Two in vivo studies utilized punch biopsies followed by histochemical staining and analysis.

RESULTS
Based on fluorescent intensity, TRV formulations delivered a large peptide more completely (2–5 fold) into ex vivo human skin than optimized liposomes. The penetration of 2 HA species in TRV formulations was 3- to 13-fold higher than with a simple gel vehicle. In the case studies, reduction of solar elastosis was observed from a topical TRV formulation.

CONCLUSION
Topical delivery of large peptides and HA into human skin using TRV technology has been demonstrated.
A Decadal Exploration of Cutaneous Adverse Effects of FDA-Approved Cardiovascular Medications: Insights From 2013 to 2023
Authors: Jallorina Anika , Vij Kunal , Wan Leo , Thomas Joson , Drum David , Glick Sharon A. , Lee-Wong Mary F. 
Published: December 2024

Abstract:
Given the high prevalence of cardiovascular disease in the United States, there is a critical need for new medications to improve the outcomes of these diseases. The US Food and Drug Administration has approved numerous medications that are able to effectively do so. While these drugs have significantly beneficial effects, just like any other medication, they can come with a multitude of unwanted side effects. It has been noted that cardiovascular drugs have been associated with a considerable number of dermatologic reactions. This review examines current literature on the various cutaneous manifestations of these adverse reactions. It focuses on these newly Food and Drug Administration–approved cardiovascular medications from 2013 to 2023, detailing both common and rare effects in the past decade. As more medications continue to enter the market, the necessity for awareness of more systemic side effects will continue to grow. This comprehensive review aims to guide clinicians in identifying drug-induced reactions in patients on these therapies.
Secondary Revision after Breast Reconstruction with Free Abdominal Perforator Flap: Flap Liposuction and Inframammary Fold Reconstruction
Authors: Okumura Seiko , Maruyama Yoko , Nakamura Ryota , Takanari Keisuke , Hyodo Ikuo , Iwata Hiroji , Kamei Yuzuru 
Published: December 2024

Background:
In breast reconstruction using the abdominal perforator flap, if the flap capacity is too large, secondary revision procedures can be performed to reduce flap volume and reconstruct the inframammary fold (IMF). We examined the various revision methods and cosmetic results.

Methods:
This study included 28 patients who underwent secondary revision among 216 patients who had breast reconstruction using the abdominal perforator flap between April 2012 and March 2019. The revision method, removal ability, and the inferior breast point (IBP) were analyzed using medical records.

Results:
Revision methods included incision resection in 4 cases, liposuction (LS) in 22 cases, LS and simultaneous IMF reconstruction in 2 cases, and post-LS IMF reconstruction in 1 case. The average LS amount was 317 mL (range, 100 -–700 mL). In 22 patients who underwent LS, the difference in preoperative IBP was 1 cm or more in 19 (86.4%) cases and 1 cm or less in 3 (13.6%) cases. The difference in postoperative IBP was 1 cm or more in 12 (54.5%) cases and 1 cm or less in 10 (45.5%) cases. The receiver operating characteristic curve analysis revealed that the cutoff LS amount for a postoperative IBP difference of 1 cm or less was 375 mL.

Conclusions:
The IBP was increased due to the decrease in flap volume. Revisions were completed with no difference in the LS-only IBP, especially when the LS amount was less than 375 mL. If the removal of 375 mL or more is necessary, removal or reformation of the IMF can be considered. These findings can potentially guide the planning of surgical procedures.