bluuebunny/crossref_metadata_2025_split huggingface dataset:
General methodology for inferring failure-spreading dynamics in networks
Authors: Guan Xiangyang , Chen Cynthia 
Published: August 2018

Significance
Failure spreading widely exists in many systems, but methodologies devised to understand its dynamics so far are domain-constrained and demonstrate limited applicability across different systems. This paper tackles this issue from a reverse perspective of failure-spreading processes: It takes the spreading outcomes as inputs and seeks to infer the spreading process that gives rise to the outcomes, instead of the other way around as the prevalent approaches do. Because failure-spreading outcomes are commonly observed for different systems, we envision that this approach is generally applicable and provides a promising avenue to potentially unify research on spreading dynamics across disciplines. This research will facilitate understanding system dynamics and developing control techniques for them at different systems, scales, and dimensions.
Cellular function given parametric variation in the Hodgkin and Huxley model of excitability
Authors: Ori Hillel , Marder Eve , Marom Shimon 
Published: August 2018

Significance
Macroscopic cellular function is maintained despite extensive variations in underlying elementary constituents, including the size of the cell, and the number, distribution, and kinetics of their proteins. Here, we take advantage of the sound theoretical and experimental basis of action potential generation to analyze macroscopic cellular invariance given microscopic variation. This analysis points to a significant gap between the high-dimensional level of description captured by biophysical measurements of channel function and the lower, physiological dimensionality, to which cellular function is sensitive. When examined in a lower dimension, a simple rule that relies on sodium channel slow inactivation provides a powerful homeostatic control mechanism that maintains excitability amid changes in protein concentrations and their kinetics.
HD 149277: a rare short-period SB2 system with a subsynchronously rotating magnetic He-rich primary
Authors: González J F , Hubrig S , Järvinen S P , Schöller M 
Published: August 2018

ABSTRACT
HD 149277 is a rare SB2 system with a slowly rotating magnetic He-rich primary with Prot = 25.4 d. The CFHT/ESPaDOnS archive spectra revealed Porb = 11.5192 ± 0.0005 d indicating strong subsynchronous rotation of the primary component. Such a strong subsynchronous rotation was not detected in any other SB2 system with a magnetic chemically peculiar component. Our inspection of the spectra revealed the presence of resolved Zeeman split spectral lines allowing us to determine the variability of the mean magnetic field modulus over the rotation period. The maximum of the magnetic field modulus coincides roughly with the positive extremum of the longitudinal field, whereas the minimum of the modulus with the negative extremum of the longitudinal field. No evidence for a longitudinal magnetic field was seen in the circularly polarized spectra of the secondary component. Using archival data from the ASAS3 survey, we find in the frequency spectrum only one significant peak, corresponding to the period Pphot = 25.390 ± 0.014 d. This value is in good agreements with the previous determination of the rotation period, Prot = 25.380 ± 0.007 d, which was based on longitudinal magnetic field measurements.
There and back again: metagenome-assembled genomes provide new insights into two thermal pools in Kamchatka, Russia
Authors: Wilkins Laetitia G. E. , Ettinger Cassandra L. , Jospin Guillaume , Eisen Jonathan A. 
Published: August 2018

AbstractCulture-independent methods have contributed substantially to our understanding of global microbial diversity. Recently developed algorithms to construct whole genomes from environmental samples have further refined, corrected and revolutionized the tree of life. Here, we assembled draft metagenome-assembled genomes (MAGs) from environmental DNA extracted from two hot springs within an active volcanic ecosystem on the Kamchatka peninsula, Russia. This hydrothermal system has been intensively studied previously with regard to geochemistry, chemoautotrophy, microbial isolation, and microbial diversity. Using a shotgun metagenomics approach, we assembled population-level genomes of bacteria and archaea from two pools using DNA that had previously been characterized via 16S rRNA gene clone libraries. We recovered 36 MAGs, 29 of medium to high quality, and placed them in the context of the current microbial tree of life. We highlight MAGs representing previously underrepresented archaeal phyla (Korarchaeota, BathyarchaeotaandAciduliprofundum) and one potentially new species within the bacterial genusSulfurihydrogenibium. Putative functions in both pools were compared and are discussed in the context of their diverging geochemistry. This study can be considered complementary to foregoing studies in the same ecosystem as it adds more comprehensive information about phylogenetic diversity and functional potential within this highly selective habitat.
The N-end Rule Pathway and Ubr1 enforce protein compartmentalization via N-terminally-encoded cellular location signals
Authors: Tran Anthony 
Published: August 2018

AbstractThe Arg/N-end rule pathway, a mechanism of protein degradation conserved from yeast to humans, is involved in cellular protein quality control, but its role has only been vaguely understood. Through systematic examination of single residue mutants of model misfolded substrates, and global analyses of yeast proteins, we discovered that Ubr1, an E3 ligase of the Arg/N-end rule, degrades organellar proteins that fail to reach their intended subcellular compartments. We determined that recognition by Ubr1 is dependent on location signals that are naturally embedded into the 2nd amino acid residue of the majority of proteins. The N-end rule pathway is thus likely to have been critical to the evolution of endosymbiotic relationships which paved the way for advanced eukaryotic cellular life.Significance StatementThis work elucidates a novel role for the N-end Rule Pathway, a protein degradation pathway highly conserved from yeast to humans. We demonstrate that the N-end rule pathway enforces the cellular compartmentalization of ER and mitochondrial proteins by degrading them when they fail to successfully translocate into their intended destinations and thus become mislocalized to the cytosol. This mechanism prevents the accumulation of toxic foreign proteins within the cytosol. Recognition of the displaced proteins is dependent on cellular location signals programmed into the 2nd residue of the target proteins, as well as the tendency for the proteins to misfold in a foreign environment. These findings have significant relevance to research on the mechanisms causing human diseases involving protein misfolding.
Therapeutic effects of Hypoxia-Inducible Factor-1α (HIF-1α) on bone formation around implants in diabetic mice
Authors: Oh Sang-Min , Shin Jin-Su , Kim Il-Koo , Moon Jae-Seung , Kim Jung-Ho , Lee Sang-Kyou , Lee Jae-Hoon 
Published: August 2018

AbstractPatients with uncontrolled diabetes are susceptible to implant failure due to impaired bone metabolism. Hypoxia-Inducible Factor 1α (HIF-1α), a transcription factor that is up-regulated in response to reduced oxygen condition during the bone repair process after fracture or osteotomy, is known to mediate angiogenesis and osteogenesis. However, its function is inhibited under hyperglycemic conditions in diabetic patients. The aim of this study is to evaluate the effects of exogenous HIF-1α on bone formation around implants by applying HIF-1α to diabetic mice via a novel PTD-mediated DNA delivery system. Smooth surface implants (1mm in diameter; 2mm in length) were placed in the both femurs of diabetic and normal mice. HIF-1α and placebo gels were injected to implant sites of the right and left femurs, respectively: Normal mouse with HIF-1α gel (NH), Normal mouse with placebo gel (NP), Diabetic mouse with HIF-1α gel (DH), and Diabetic mouse with placebo gel (DP). RNA sequencing was performed 4 days after surgery. Based on RNA sequencing, Differentially Expressed Genes (DEGs) were identified and HIF-1α target genes were selected. Histologic and histomorphometric results were evaluated 2 weeks after the surgery. The results showed that bone-to-implant contact (BIC) and bone volume (BV) were significantly greater in the DH group than the DP group (p < 0.05). A total of 216 genes were differentially expressed in DH group compared to DP group. On the other hand, there were 95 DEGs in the case of normal mice. Twenty-one target genes of HIF-1α were identified in diabetic mice through bioinformatic analysis of DEGs. Among the target genes, NOS2, GPNMB, CCL2, CCL5, CXCL16 and TRIM63 were manually found to be associated with wound healing-related genes. In conclusion, local administration of HIF-1α via PTD may help bone formation around the implant and induce gene expression more favorable to bone formation in diabetic mice.
Characterization of the Rosa roxbunghii Tratt transcriptome and analysis of MYB genes
Authors: Huang Xiaolong , Yan Huiqing , Zhai Lisheng , Yang Zhengting , Yi Yin 
Published: August 2018

AbstractRosa roxbunghii Tratt belongs to the Rosaceae family, and the fruit is flavorful, economic, and highly nutritious, providing health benefits. MYB proteins play key roles in R. roxbunghii’ fruit development and quality. However, the available genomic and transcriptomic information are extremely deficient. Here, a normalized cDNA library was constructed using five tissues, stem, leaf, flower, young fruit, and mature fruit, with three repetitions, and sequenced using the Illumina HiSeq 2500 platform. De novo assembly was performed, and 470.66 million clean reads were obtained. In total, 63,727 unigenes, with an average GC content of 42.08%, were determined and 59,358 were annotated. In addition, 9,354 unigenes were assigned the Gene Ontology category, and 20,202 unigenes were assigned to 25 Eukaryotic Ortholog Groups. Additionally, 19,507 unigenes were classified into 140 pathways of the Kyoto Encyclopedia of Genes and Genomes database. Using the transcriptome, 18 candidate MYB genes that were significantly expressed in mature fruit, compared with other tissues, were obtained. Among them, 10 R2R3 MYB and 1 R1 MYB were identified. The expression levels of 12 MYB genes randomly selected for qRT-PCR analysis were consistent with the RNA-seq results. A total of 37,545 microsatellites were detected, with an average EST-–SSR frequency of 0.59 (37,545/63,727). This transcriptome data will be valuable for identifying genes of interest and studying their expression and evolution.
Adaptability of mass housing: size modification of flats as a response to segregation
Authors: Huuhka Satu , Saarimaa Sini 
Published: August 2018

Purpose
When dwellings fail to respond to residents’ needs, housing will suffer from segregation and buildings will possibly be demolished ahead of their time. This paper focuses on the lack of variation in the sizes of dwellings as a factor in residential segregation. It examines this issue in the context of Finnish mass housing built in the 1960s and 1970s. The purpose of the paper is to review how mass housing layouts can be adapted to produce the currently absent flat sizes.

Design/methodology/approach
The paper operates at the intersection of human geography, building stock research and adaptability research. First, statistical data are utilized to investigate how dwellings and households of different sizes are distributed over the Finnish housing stock. Second, the building layouts of mass housing are examined in detail. Third, the potential that flats in mass housing have for size modification is reviewed.

Findings
There is a disparity of available dwelling sizes between different housing types, and statistics show that the proportion of large households has decreased significantly in blocks of flats over the last decades. The lack of large dwellings in mass housing may contribute as one factor to the segregation of the neighborhoods built in the 1960s and 1970s. The findings show how the variation of apartment sizes can be increased in mass housing.

Originality/value
The housing stock is rarely examined in detail in segregation research, even though it is a major determinant for a city’s social structure. This paper argues that to address segregation sustainably, it is necessary to understand the housing stock better and to view it as an adaptable asset.
An environmental awareness purchasing intention model
Authors: Xu Lu , Prybutok Victor , Blankson Charles 
Published: August 2018

Purpose
This paper posits, develops and tests the effects of general environmental awareness factors on consumers’ intentions in the Environmental Awareness Purchasing Intention Model. Environmental awareness is tested within the context of purchasing vehicles and, thus, vehicle relevant factors (perceived quality and self-image) are also included. Further, the purpose of this paper is to explain the relative contribution of general environmental awareness factors on purchasing intentions compared to quality and self-image.

Design/methodology/approach
The main thrust of the research involved a survey of 248 young automobile buyers from a large public university in Texas, USA. The data were analyzed using both multiple regression and partial least square-structural equation modeling (PLS-SEM).

Findings
Environmental attitude has a positive impact on purchasing intention, while perceived control toward environmentally responsible behavior has a negative impact. Results also show a positive impact of quality and self-image on intention to purchase environmentally friendly cars. Furthermore, the results reveal that environmental awareness factors explain less variance than perceived quality. At the same time, the results show that environmental factors, relatively, explain more variance in the decision-making process than self-image.

Originality/value
This is the first study to examine the relationship between general environmental awareness and the intention to purchase an environmentally friendly car. This study contributes to sustainable consumption literature in operations management. The paper also provides insights for developing managerial guidelines for car manufacturers based on the understanding of factors influencing environmentally friendly car purchasing intentions.
Fuzzy control-based bolt tightening for power cable maintenance robot
Authors: Jiang Wei , Zhou Zhiyuan , Yan Yu , Wu Gongping , Yu Lianqing , Li Hong Jun , Chen Wei 
Published: August 2018

Purpose
In response to the poor reliability of live maintenance robots in semi-structured environments and the difficulty of monitoring their operation status, this paper aims to propose an online method for evaluating the operation status of high-voltage live maintenance robots based on fuzzy control.

Design/methodology/approach
The robot bolt tightening operation is taken as an example. During the whole operation process, the key technologies of bolt tightening are analyzed theoretically, a two-dimensional fuzzy control model of bolt tightening process control is established and the control parameters, which characterize the operation status, are obtained. Through dynamic adjustment of the fuzzy controller, real-time online monitoring of the robot operation status can be achieved.

Findings
The results of simulation experiments and 220 kV live operation experiments show that the reliability of robot bolt tightening is greatly enhanced by the proposed control method.

Originality/value
The results not only verify the engineering practicability of the fuzzy control-based method but also indicate that it can improve efficiency, safety and operability.
Dynamic frontier estimation for monitoring team performances
Authors: Yılmaz Melike , Aksezer Çağlar , Atan Tankut 
Published: August 2018

Purpose
This paper aims to investigate how predictions of football league standings and efficiency measures of teams, obtained through frontier estimation technique, evolve compared to actual results.

Design/methodology/approach
The study is based on data from the Turkish first division football league. Historical data for five seasons, from 2011 to 2016, are used to compare weekly estimates to de facto results. Data envelopment analysis efficiency measures are used to estimate team performances. After each week, a data envelopment analysis is run using available data until then, and final team standings are estimated via computed efficiencies. Estimations are improved by using a data envelopment analysis model that incorporates expert knowledge about football.

Findings
Results indicate that deductions can be made about the league’s future progress. Model incorporating expert knowledge tends to estimate the performance better. Although the prediction accuracy starts out low in early stages, it improves as the season advances. Scatter of individual teams’ performances show fluxional behaviour, which attracts studying the impact of uncontrollable factors such as refereeing.

Originality/value
While all previous studies focus on season performance, this study handles the problem as a combination of weekly performance and how it converges to reality. By tracking weekly performance, managers get a chance to confront their weak performance indicators and achieve higher ranking by improving on these inefficiencies.
Changes in tissue oxygen tension, venous saturation, and Fick‐based assessments of cardiac output during hyperoxia
Authors: Perry Dorothy A. , Thomson Lindsay M. , Pigula Frank A. , Polizzotti Brian D. , DiNardo James A. , Nedder Arthur , Gauvreau Kimberlee , Kheir John N. 
Published: August 2018

AbstractBackgroundHyperoxemia (arterial oxygen tension >100 mm Hg) may occur in critically ill patients and have effects on mixed venous saturation (SvO2) and on Fick‐based estimates of cardiac output (CO). We investigated the effect of hyperoxemia on SvO2 and on assessments of CO using the Fick equation.MethodsYorkshire swine (n = 14) were anesthetized, intubated, and paralyzed for instrumentation. SvO2 (co‐oximetry) and tissue oxygen tension (tPO2, implantable electrodes) in brain and myocardium were measured during systematic manipulation of arterial oxygen tension (PaO2) using graded hyperoxia (fraction of inspired oxygen 0.21 → 0.8). Secondarily, oxygen‐ and carbon dioxide‐based estimates of CO (FickO2 and FickCO2, respectively) were compared with measurements from a flow probe placed on the aortic root.ResultsIndependent of changes in measured oxygen delivery, cerebral and myocardial tPO2 increased in proportion to PaO2, as did SvO2 (P < 0.001 for all). Based on mixed model analysis, each 100 mm Hg increase in PaO2 resulted in a 4.8 ± 0.9% increase in SvO2 under the conditions tested. Because neither measured oxygen consumption, arterial oxyhemoglobin saturation or cardiac output varied significantly during hyperoxia, changes in SvO2 resulted in successively increasing errors in FickO2 during hyperoxia (34% during normoxia, 72% during FiO2 0.8). FickCO2 lacked the progressively worsening errors present in FickO2, but correlated poorly with CO.ConclusionSvO2 acutely changes following changes in PaO2 even absent changes in measured DO2. This may lead to errors in FickO2 estimates of CI. Further work is necessary to understand the impact of this phenomenon in disease states.
Longitudinal associations between food insecurity and substance use in a cohort of women with or at risk for HIV in the United States
Authors: Whittle Henry J. , Sheira Lila A. , Frongillo Edward A. , Palar Kartika , Cohen Jennifer , Merenstein Daniel , Wilson Tracey E. , Adedimeji Adebola , Cohen Mardge H. , Adimora Adaora A. , Ofotokun Ighovwerha , Metsch Lisa , Turan Janet M. , Wentz Eryka L. , Tien Phyllis C. , Weiser Sheri D. 
Published: August 2018

Background and AimsFew longitudinal studies have examined the relationship between food insecurity and substance use. We aimed to investigate this relationship using longitudinal data among women with or at risk for HIV in the United States.DesignWomen's Interagency HIV Study (WIHS), a prospective cohort study.SettingNine sites across the United States.ParticipantsA total of 2553 women with or at risk for HIV.MeasurementsSemi‐annual structured interviews were conducted during April 2013–March 2016. Food security (FS) was the primary predictor, measured using the Household Food Security Survey Module. Outcomes were: any illicit substance use except cannabis; licit or illicit cannabis use; stimulant use (crack, cocaine, or methamphetamine); opioid use (heroin or methadone in a non‐prescribed way); and prescription drug misuse (prescription narcotics, amphetamines, or tranquilizers in a non‐prescribed way) since the last visit. We used multivariable logistic regression with random effects to examine longitudinal associations of current and previous FS with the outcomes simultaneously, adjusting for socio‐demographic factors, HIV serostatus, physical health and health insurance.FindingsAverage number of visits was 4.6. At baseline, 71% of participants were HIV‐seropositive, 44% reported marginal, low, or very low FS, and 13% were using illicit substances. In adjusted analyses, current low and very low FS were significantly associated with 1.59 [95% confidence interval (CI) = 1.02, 2.46; P = 0.039] and 2.48 (95% CI = 1.52, 4.04; P < 0.001) higher odds of any illicit substance use, compared to high FS, and also with higher odds of cannabis, stimulant and opioid use, exhibiting a consistent dose–response relationship. Marginal, low, and very low FS at the previous visit were associated with 1.66 (95% CI = 1.08, 2.54; P = 0.020), 1.77 (95% CI = 1.14, 2.74; P = 0.011), and 2.28 (95% CI = 1.43, 3.64; P < 0.001) higher odds of current illicit substance use.ConclusionsFood insecurity appears to be longitudinally associated with substance use among US women with or at risk for HIV.
What are the beliefs and perceptions of practice nurses’ influence about the uptake of the measles, mumps, and rubella vaccine?: An integrative literature review
Authors: Hill Marie Catherine , Salmon Debra , Aitken Leanne M. 
Published: August 2018

AbstractAimThe aim of this study was to ascertain the beliefs and perceptions of practice nurses’ influence about the uptake of the measles, mumps, and rubella vaccine.BackgroundImmunization decision‐making for parents is a complex process. Principle health professionals involved in immunization programmes are health visitors, general practitioners, and practice nurses. There is evidence that health visitors and general practitioners influence parental immunization decision‐making. However, there is a lack of evidence about the influence of the practice nurse despite their well‐documented role in immunization.DesignIntegrative literature review.Data sourcesA systematic search of electronic databases, including CINAHL; Medline; PubMed; Google Scholar; ScienceDirect; and Scopus from February 1998 – April 2017. Hand searching and reviewing of secondary references were also undertaken.Review methodsTwo reviewers independently screened records on title and abstract. Studies where the beliefs and perceptions of practice nurses about the measles, mumps, and rubella vaccine were explored and were published in English were included. The data were analysed using the integrative review processes.ResultsTwelve studies were included; these studies were principally descriptive and were of variable methodological quality. Four themes were identified: parental immunization influencing factors, practice nurse characteristics, information and communication, and personal views and concerns. While this review provides an excellent baseline for this information, more recent research conducted in the current policy environment is urgently needed to determine if these views persist.ConclusionImmunization training and annual updates are essential for practice nurses to keep abreast with the evidence base underpinning national immunization programmes.