bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of Cisplatin‐based chemotherapy on the osseointegration of dental implants: An in vivo mechanical and histometrical study
Authors: Dantas Marcos Vinícius Mendes , Verzola Mário Henrique Arruda , Sanitá Paula Volpato , Dovigo Lívia Nordi , Cerri Paulo Sérgio , Gabrielli Marisa Aparecida Cabrini 
Published: April 2019

AbstractObjectivesTo evaluate the effect of Cisplatin on bone repair and mineralization around implants and on the mechanical properties of bone tissue.Materials and methodsForty‐three Wistar rats were randomly divided into two groups: Cisplatin (CIS, medication) and control (CTL, placebo solution), administered once a week for 4 weeks. After 4 weeks, implants were installed in both tibiae metaphysis. After 30 and 60 days, the animals were sacrificed and their femurs and tibiae were removed. Femurs were subjected to mechanical tests and tibiae for removal torque, arrangement and distribution of collagen fibers, morphometrical analyses (bone tissue in contact with the implant surface [BIC] and areal fraction between implant threads occupied by bone tissue [BAFO]) and scanning electron microscopy to calcium and calcium/phosphorus analysis. Data were analyzed by ANOVA or MANOVA, and Tukey or Games–Howell post hoc tests, respectively (α = 0.05).ResultsThe CTL specimens had significantly higher values (0.0001 ≤ p≤0.036) of strength (N), removal torque (N/cm2), %BIC, and %BAFO than CIS specimens, being their best results at day 60. No significant differences were found among the groups regarding the values of deformation, percentage of calcium, and calcium/phosphorus ratio. In CIS groups, there was a reduction in the organization of collagen at the bone/implant interface, resulting in a trabecular bone with thin trabeculae and birefringent collagen and irregular arrangement.Conclusions and clinical implicationsCisplatin interfered negatively in the repair and mineralization around dental implants, as well as on the quality of the bone tissue, mainly in the period of 30 days after the implant placement.
The effect of five mechanical instrumentation protocols on implant surface topography and roughness: A scanning electron microscope and confocal laser scanning microscope analysis
Authors: Cha Jae‐Kook , Paeng Kyeongwon , Jung Ui‐Won , Choi Seong‐Ho , Sanz Mariano , Sanz‐Martín Ignacio 
Published: April 2019

AbstractObjectiveTo evaluate in vitro the changes in implant surface topography and roughness of commercial implants after instrumentation with five decontamination protocols.Material and methodsSeventy‐two titanium implants with a sandblasted and acid‐etched (SLA) surface were placed 5 mm supra‐crestally. Five groups of twelve implants were instrumented with the following protocols: a metal scaler tip (SCAL), a thermoplastic scaler tip (PEEK), a round titanium brush (RBRU), a tufted brush with titanium bristles (TNBRU), and a glycine‐based air‐powder abrasive (GLYC). A sixth group with untreated implants was used as control. Scanning electron microscope and confocal laser scanning microscope were utilized to evaluate the changes in the implant surfaces.ResultsThe SCAL caused pronounced macroscopic alterations and damage of the implant surface, the PEEK left remnants of the plastic tip in the implant surface, and both titanium brush groups flattened the thread profile, while minimal alterations were observed in the GLYC. When compared to the control group, the roughness parameters (Sa) in the buccal aspect increased in the thread area of SCAL, and a minor reduction was observed in the PEEK while in the other groups, these values remained unchanged. In the valley areas, however the RBRU, TNBRU, and GLYC experienced a significant reduction (smoothening) indicating different accessibility of the decontamination protocols to the thread and valley. Similarly, the buccal aspects had more pronounced changes than those in the palatal aspect.ConclusionWithin the limitations of this in vitro investigation, the tested protocols induced different macroscopic alterations and surface roughness changes that varied in the thread and valley area.
Human T‐cell lymphotrophic virus in solid‐organ transplant recipients: Guidelines from the American society of transplantation infectious diseases community of practice
Authors: Kaul Daniel R. , Sharma Tanvi S. ,   on behalf of the AST ID Community of Practice
Published: April 2019

AbstractThese updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of Human T‐cell lymphotrophic virus 1 (HTLV)‐1 in the pre‐ and post‐transplant period. HTLV‐1 is an oncogenic human retrovirus rare in North America but endemic in the Caribbean and parts of Africa, South America, Asia, and Oceania. While most infected persons do not develop disease, <5% will develop adult T‐cell leukemia/lymphoma or neurological disease. No proven antiviral treatment for established HTLV‐1 infection is available. The effect of immunosuppression on the development of HTLV‐1‐associated disease in asymptomatically infected recipients is not well characterized, and HTLV‐1‐infected individuals should be counseled that immunosuppression may increase the risk of developing HTLV‐1‐associated disease and they should be monitored post‐transplant for HTLV‐1‐associated disease. Currently approved screening assays do not distinguish between HTLV‐1 and HTLV‐2, and routine screening of deceased donors without risk factors in low seroprevalence areas is likely to result in significant organ wastage and is not recommended. Targeted screening of donors with risk factors for HTLV‐1 infection and of living donors (as time is available to perform confirmatory tests) is reasonable.
Children can optimally integrate multisensory information after a short action‐like mini game training
Authors: Nava Elena , Föcker Julia , Gori Monica 
Published: April 2019

AbstractCombining information across different sensory modalities is of critical importance for the animal's survival and a core feature of human's everyday life. In adulthood, sensory information is often integrated in a statistically optimal fashion, so that the combined estimates of two or more senses are more reliable than the best single one. Several studies have shown that young children use one sense to calibrate the others, which results in unisensory dominance and undermines their optimal multisensory integration abilities. In this study we trained children aged 4–5 years with action‐like mini games, to determine whether it could improve their multisensory as well as their visuo‐spatial skills. Multisensory integration abilities were assessed using a visuo‐haptic size discrimination task, while visuo‐spatial attention skills were investigated using a multiple object tracking task (MOT). We found that 2‐weeks training were sufficient to observe both optimal multisensory integration and visuo‐spatial enhancements selectively in the group trained with action‐like mini games. This plastic change persisted up to 3 months, as assessed in a follow‐up. Our novel findings reveal that abilities that are commonly known to emerge in late childhood can be promoted in younger children through action‐like mini games and have long‐lasting effects. Our data have clinical implications, in that they suggest that specific trainings could potentially help children with multisensory integration deficits.
Calcitonin Gene‐Related Peptide Modulators – The History and Renaissance of a New Migraine Drug Class
Authors: Hargreaves Richard , Olesen Jes 
Published: April 2019

Several lines of evidence pointed to an important role for CGRP in migraine. These included the anatomic colocalization of CGRP and its receptor in sensory fibers innervating pain‐producing meningeal blood vessels, its release by trigeminal stimulation, the observation of elevated CGRP in the cranial circulation during migraine with normalization concomitant with headache relief by sumatriptan, and translational studies with intravenous (IV) CGRP that evoked migraine only in migraineurs. The development of small molecule CGRP receptor antagonists (CGRP‐RAs) that showed clinical antimigraine efficacy acutely and prophylactically in randomized placebo‐controlled clinical trials subsequently gave definitive pharmacological proof of the importance of CGRP in migraine. More recently, CGRP target engagement imaging studies using a CGRP receptor PET ligand [11C]MK‐4232 demonstrated that there was no brain CGRP receptor occupancy at clinically effective antimigraine doses of telcagepant, a prototypic CGRP‐RA. Taken together, these data indicated that (1) the therapeutic site of action of the CGRP‐RAs was peripheral not central; (2) that IV CGRP had most likely evoked migraine through an action at sites outside the blood‐brain barrier; and (3) that migraine pain was therefore, at least in part, peripheral in origin. The evolution of CGRP migraine science gave impetus to the development of peripherally acting drugs that could modulate CGRP chronically to prevent frequent episodic and chronic migraine. Large molecule biologic antibody (mAb) approaches that are given subcutaneously to neutralize circulating CGRP peptide (fremanezumab, galcanezumab) or block CGRP receptors (erenumab) have shown consistent efficacy and tolerability in multicenter migraine prevention trials and are now approved for clinical use. Eptinezumab, a CGRP neutralizing antibody given IV, shows promise in late stage clinical development. Recently, orally administered next‐generation small molecule CGRP‐RAs have been shown to have safety and efficacy in acute treatment (ubrogepant and rimegepant) and prevention (atogepant) of migraine, giving additional CGRP‐based therapeutic options for migraine patients.
Observational analysis of disparities in obesity in children in the UK: Has Leeds bucked the trend?
Authors: Rudolf Mary , Perera Rafael , Swanston Di , Burberry Janice , Roberts Kim , Jebb Susan 
Published: April 2019

SummaryBackgroundThe prevalence of obesity in childhood is of high concern, especially in deprived populations. We explored trends in obesity following the introduction of a citywide strategy focused on preschool children.MethodsAnalysis of obesity prevalence using the National Child Measurement Programme 2009 to 2017 for primary‐school children in Leeds using 5‐year aggregated data for Leeds, comparable cities, and England as a whole.ResultsPrevalence of obesity in Leeds for school entry children fell significantly (9.4% to 8.8%), whilst comparable cities (CC) and England as a whole showed no change (comparison of trends: P < 0.001 and P < 0.001). The reduction in Leeds was primarily in the most deprived (11.5% to 10.5%; trend comparison CC: P < 0.001, Eng: P < 0.001), but also amongst the affluent (6.8% to 6.0%; trend comparison CC: P = 0.087, Eng: P = 0.012).Prevalence in older children in Leeds was unchanged whilst it increased for comparable cities and England (trend comparison CC: P < 0.001, Eng: P < 0.001). In the deprived, obesity increased: Leeds by 1.4%; CC 1.3%, England 1% (trend comparison Eng: P = 0.004). In the affluent, obesity prevalence reduced more in Leeds than elsewhere: 2% in Leeds, 0.8% in CC, and 0.7% in England (trend comparison CC: P < 0.001, Eng: P ≤ 0.001).ConclusionsThere has been a notable decrease in the prevalence of obesity especially amongst the most disadvantaged children at entry to primary school in Leeds. How this was achieved merits in‐depth consideration.
Factors affecting compliance with reference check requests
Authors: Hedricks Cynthia A. , Rupayana Disha D. , Fisher Peter A. , Robie Chet 
Published: April 2019

AbstractStructured reference checks have been demonstrated to be a reliable and valid predictor of job performance. However, the reference check is a unique assessment method for personnel selection in that a third party, the reference provider, is the source of the critical information on the candidate. If a reference provider is unwilling to either partially or fully comply with a reference check request, the usefulness of the reference check is likely to be compromised. This study examined the factors affecting compliance of the potential reference provider with a reference check request. The sample consisted of 905 U.S. adults who were recruited through the Prolific online crowdsourcing platform (https://prolific.ac). We asked the participants a series of questions related to their actual experiences over the past year in responding to reference check requests. We also included a between‐subjects scenario that examined whether job candidate performance, relationship to job candidate, and method of providing the employment reference would affect hypothetical compliance. The results of the study can be used to more deeply understand the factors that are related to the compliance of the reference provider, and as a result, more fully understand the value of the reference check for selection.
Examination of gamma‐irradiated calcium silicate hydrates. Part I: Chemical‐structural properties
Authors: Tajuelo Rodriguez Elena , Hunnicutt William A. , Mondal Paramita , Le Pape Yann 
Published: April 2019

AbstractThe chemical‐structural properties of synthetic calcium silicate hydrate (C‐S‐H) with C/S (Ca/Si) ratios of 0.75, 1 and 1.33 were studied after gamma irradiation‐absorbed doses ranging from 0.145 to 0.784 MGy and compared with those of control specimens. The results showed that the total water content given by thermogravimetric analysis and the dimension of the basal spacing given by x‐ray diffraction were comparable for control and irradiated samples, which indicate that the interlayer water content did not change. The morphology, C/S ratios, and silicate mean chain length were also found to be unaltered by the absorbed gamma doses.
A‐kinase‐interacting protein 1 facilitates growth and metastasis of gastric cancer cells via Slug‐induced epithelial‐mesenchymal transition
Authors: Chen Dehu , Cao Gan , Liu Qinghong 
Published: April 2019

AbstractA‐kinase‐interacting protein 1 (AKIP1) has previously been reported to act as a potential oncogenic protein in various cancers. The clinical significance and biological role of AKIP1 in gastric cancer (GC) is, however, still elusive. Herein, this study aimed to investigate the functional and molecular mechanism by which AKIP1 influences GC. AKIP1 mRNA and protein expressions in GC tissues were examined by quantitative real‐time PCR (qRT‐PCR), Western blot and immunohistochemistry. Other methods including stably transfected against AKIP1 into gastric cancer cells, wound healing, transwell assays, CCK‐8, colony formation, qRT‐PCR and Western blot in vitro and tumorigenesis in vivo were also performed. The up‐regulated expression of AKIP1 in GC specimens significantly correlated with clinical metastasis and poor prognosis in patients with GC. AKIP1 knockdown markedly suppressed GC cells proliferation, invasion and metastasis both in vitro and in vivo. In contrast, AKIP1 overexpression resulted in the opposite effects. Moreover, mechanistic analyses indicated that Slug‐induced epithelial‐mesenchymal transition (EMT) might be responsible for AKIP1‐influenced GC cells behaviour. Our findings demonstrated that high AKIP1 expression significantly correlated with clinical metastasis and unfavourable prognosis in patients with GC. Additionally, AKIP1 promoted GC cells proliferation, migration and invasion by activating Slug‐induced EMT.
Titanite dates crystallization: Slow Pb diffusion during super‐solidus re‐equilibration
Authors: Hartnady Michael I. H. , Kirkland Christopher L. , Clark Chris , Spaggiari Catherine V. , Smithies R. Hugh , Evans Noreen J. , McDonald Brad J. 
Published: April 2019

AbstractTitanite can be found in rocks of wide compositional range, is reactive, growing or regrowing during metamorphic and hydrothermal events, and is generally amenable to U–Pb geochronology. Experimental evidence suggest that titanite has a closure temperature for Pb ranging from 550 to 650°C, and thus titanite dates are commonly interpreted as cooling ages. However, this view has been challenged in recent years by evidence from natural titanite which suggests the closure temperature may be significantly higher (up to 800°C). Here, we investigate titanite in an enclave of migmatitic gneiss included within a granite intrusion. The titanite crystals exhibit textural features characteristic of fluid‐mediated mass transfer processes on length scales of <100 µm. These textural features are associated with variation in both Pb concentrations and distinct U–Pb isotopic compositions. Zr‐in‐titanite thermometry indicates that modification of the titanite occurred at temperatures in excess of 840°C, in the presence of a high‐T silicate melt. The Pb concentration gradients preserved in these titanite crystals are used to determine the diffusivity of Pb in titanite under high‐T conditions. We estimate diffusivities ranging from 2 × 10−22 to 5 × 10−25 m2/s. These results are significantly lower than experimental data predict yet are consistent with other empirical data on natural titanites, suggesting that Pb diffusivity is similar to that of Sr. Thus our data challenge the wide‐held assumption that U–Pb titanite dates only reflect cooling ages.
Characterization of chitinase from Streptomyces luridiscabiei U05 and its antagonist potential against fungal plant pathogens
Authors: Swiontek Brzezinska Maria , Jankiewicz Urszula , Kalwasińska Agnieszka , Świątczak Joanna , Żero Klaudia 
Published: April 2019

AbstractStreptomyces luridiscabiei U05 was isolated from wheat rhizosphere. It produced chitinase, which showed in vitro antifungal properties. The crude enzyme inhibited the growth of Alternaria alternata, Fusarium oxysporum, F. solani, Botrytis cinerea, F. culmorum and Penicillium verrucosum. The chitinase enzyme of the molecular weight of 45 kDa was purified using affinity chromatography of chitin. Streptomyces luridiscabiei U05 produced different chitinolytic enzymes. The highest enzyme activity was observed with the use of 4‐MU‐(GlcNAc), which points to the presence of an β‐N‐acetylhexosaminidase. The optimum activity was obtained at 35–40°C and pH 7–8. The enzyme showed thermostability at 35–40°C during 240 min of preincubation and lost its activity at 50°C and 60°C in 60 min. The chitinase activity from S. luridiscabei U05 was strongly inhibited by Hg2+ and Pb2+ ions, and sodium dodecyl sulphate (SDS). The Ca2+, Cu2+ and Mg2+ ions stimulated the activity of the enzyme.
Effect of dietary energy on digestibilities, rumen fermentation, urinary purine derivatives and serum metabolites in Tibetan and small‐tailed Han sheep
Authors: Zhou Jianwei , Wang Wenji , Jing Xiaoping , Degen Allan , Guo Yamin , Kang Jingpeng , Shang Zhanhuan , Yu Zhongxiang , Qiu Qiang , Guo Xusheng , Ding Luming , Yang Guo , Long Ruijun 
Published: April 2019

AbstractTibetan sheep are indigenous to the Qinghai–Tibetan Plateau, graze the grassland all year round without supplementation and are well‐adapted to the harsh conditions. Small‐tailed Han sheep were introduced to the plateau and are raised mainly in feedlots. Based on their different backgrounds, we hypothesized that the ability to cope with poor diets would be better in Tibetan than in Han sheep. To test our prediction, we examined the effect of dietary energy on apparent digestibilities, rumen fermentation, urinary purine derivatives and serum metabolites by using a 4 × 4 Latin square design in each sheep breed. Four diets were formulated to be low in crude protein (~7%) but to differ in metabolizable energy concentration. Average daily gain was greater in Tibetan than in Han sheep (p < 0.01) and increased linearly with an increase in energy intake (p < 0.001). The digestibilities of dry matter, organic matter, gross energy, and neutral and acid detergent fibres were greater in Tibetan than in Han sheep (p < 0.05). Ruminal pH was lower (p < 0.05), while volatile fatty acids (VFAs), urea‐N, ammonia‐N and soluble protein‐N concentrations were higher (p < 0.05) in Tibetan than in Han sheep. As a molar proportion of total VFA, acetate decreased (p < 0.001) with an increase in dietary energy whereas propionate and butyrate increased (p < 0.05). Urinary purine derivative excretion was greater in Tibetan than in Han sheep (p < 0.01), as was microbial nitrogen production; both parameters increased with dietary energy (p < 0.01). Serum concentrations of glucose, insulin and insulin‐like growth factor‐1 increased (p < 0.05) as energy level increased, while non‐esterified fatty acids and growth hormone decreased (p < 0.05). It was concluded that Tibetan sheep were better able to cope with low‐protein, low‐energy diets and, consequently, our prediction was supported.
Importance of Driving and Potential Impact of Driving Cessation for Rural and Urban Older Adults
Authors: Strogatz David , Mielenz Thelma J. , Johnson Andrew K. , Baker Ida R. , Robinson Melinda , Mebust Sean P. , Andrews Howard F. , Betz Marian E. , Eby David W. , Johnson Renee M. , Jones Vanya C. , Leu Cheng Shiun , Molnar Lisa J. , Rebok George W. , Li Guohua 
Published: April 2019

AbstractPurposeAnalyses compared older drivers from urban, suburban, and rural areas on perceived importance of continuing to drive and potential impact that driving cessation would have on what they want and need to do.MethodsThe AAA LongROAD Study is a prospective study of driving behaviors, patterns, and outcomes of older adults. A cohort of 2,990 women and men 65‐79 years of age was recruited during 2015‐2017 from health systems or primary care practices near 5 study sites in different parts of the United States. Participants were classified as living in urban, surburban, or rural areas and were asked to rate the importance of driving and potential impact of driving cessation. Logistic regression models adjusted for sociodemographic and driving‐related characteristics.FindingsThe percentages of older drivers rating driving as “completely important” were 76.9%, 79.0%, and 83.8% for urban, suburban, and rural drivers, respectively (P = .009). The rural drivers were also most likely to indicate driving cessation would have a high impact on what they want or need to do (P < .001). After adjustment for sociodemographic and driving‐related characteristics, there was a 2‐fold difference for rural versus urban older drivers in odds that driving cessation would have a high impact on what they need to do (OR = 2.03; 95% CI: 1.60‐2.58).ConclusionsOlder drivers from rural areas were more likely to rate driving as highly important and the prospect of driving cessation as very impactful. Strategies to enhance both the ability to drive safely and the accessibility of alternative sources of transportation may be especially important for older rural adults.