bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the Strength of the Association Between Industry Payments and Prescribing Practices in Oncology
Authors: Mitchell Aaron P. , Winn Aaron N. , Lund Jennifer L. , Dusetzina Stacie B. 
Published: February 2019

Abstract

Background
Financial relationships between physicians and the pharmaceutical industry are common, but factors that may determine whether such relationships result in physician practice changes are unknown.

Materials and Methods
We evaluated physician use of orally administered cancer drugs for four cancers: prostate (abiraterone, enzalutamide), renal cell (axitinib, everolimus, pazopanib, sorafenib, sunitinib), lung (afatinib, erlotinib), and chronic myeloid leukemia (CML; dasatinib, imatinib, nilotinib). Separate physician cohorts were defined for each cancer type by prescribing history. The primary exposure was the number of calendar years during 2013–2015 in which a physician received payments from the manufacturer of one of the studied drugs; the outcome was relative prescribing of that drug in 2015, compared with the other drugs for that cancer. We evaluated whether practice setting at a National Cancer Institute (NCI)-designated Comprehensive Cancer Center, receipt of payments for purposes other than education or research (compensation payments), maximum annual dollar value received, and institutional conflict-of-interest policies were associated with the strength of the payment-prescribing association. We used modified Poisson regression to control confounding by other physician characteristics.

Results
Physicians who received payments for a drug in all 3 years had increased prescribing of that drug (compared with 0 years), for renal cell (relative risk [RR] 1.81, 95% confidence interval [CI] 1.58–2.07), CML (RR 1.22, 95% CI 1.08–1.39), and lung (RR 1.69, 95% CI 1.58–1.82), but not prostate (RR 0.97, 95% CI 0.93–1.02). Physicians who received compensation payments or &gt;$100 annually had increased prescribing compared with those who did not, but NCI setting and institutional conflict-of-interest policies were not consistently associated with the direction of prescribing change.

Conclusion
The association between industry payments and cancer drug prescribing was greatest among physicians who received payments consistently (within each calendar year). Receipt of payments for compensation purposes, such as for consulting or travel, and higher dollar value of payments were also associated with increased prescribing.
Advantage of ultrasonography in the diagnosis of acute appendicitis at Al-Karama Teaching Hospital
Authors: Surriah Mohammed Hillu , Bakkour Amine Mohammed , Hussain Nidaa Ali Abdul 
Published: February 2019

Background: The clinical diagnosis of acute appendicitis remains a challenge to surgeons. Different aids were introduced to improve the diagnostic accuracy. Among these modalities, ultrasonography is simple, easily available, non-invasive, convenient and cost effective. The aim of the study was to determine the validity of ultrasound in diagnosis of the acute appendicitis in those with clinically diagnosed patients.Methods: A cross sectional study was carried out in Al-Karama teaching hospital for thirty months from the period of 1st June 2016 to 1st December 2018. All patients with suspected appendicitis underwent clinical evaluation then sent for US. Results of surgeries, where relevant, were compared against US results. Positive and negative appendices on histopathology were regarded in accordance to the criteria which was negative appendectomy was defined as normal looking appendix and absence of acute inflammation on histopathology while positive cases included appendices showing acute inflammatory changes. Sensitivity, specificity and overall accuracy was calculated.Results: A total of 435 patients with suspected appendicitis, males 224 (51.49%) and females 211 (48.50%) were included in present study. There were no significant differences between patients with positive and negative histopathology findings regarding presenting symptoms. There was a significant association between (cough sign, localized tenderness sign and pointing sign) and patients with positive histopathology findings. Regarding to the validity results of ultrasound in comparison to histopathology findings were accuracy 87.6%, sensitivity 87.8%, specificity 85.3%, positive predictive value 98.6% and negative predictive value 62.8%.Conclusions: The ultrasonography had a good accuracy, sensitivity and specificity in diagnosing acute appendicitis cases. Negative with ultrasonography results should be re-examined with different diagnostic technique like CT-scan.
Acute mesenteric artery occlusion in hypobaric oxygen environment
Authors: Al-Saeed Mohammed 
Published: February 2019

Background: Acute mesenteric ischemia represents a challenge in Taif and related districts where hypobaric oxygen may add to other risk factors as prevalence of diabetes mellitus and obesity. The aim of this retrospective study was to record and discuss the underlying risk factors, pattern of presentation, methods of diagnosis and results of treatment of acute mesenteric ischemia in Taif Tertiary Hospitals.Methods: In this chart review and database study, thirty-one patients met the inclusion criteria in the period from January 2009 to December 2017. The outcomes included demographics, risk factors, clinical findings, diagnostic and therapeutic methods, in addition to the mortality and follow up of the study population.Results: The commonest presenting symptom was abdominal pain (100%), of them 45.2% had marked peritoneal signs. Diagnosis was established by CT angiography in 41.9% and after exploratory laparotomy in 58.1% of patients. Mesenteric artery thrombosis was the cause in 64.5% and embolism in 35.5%. In all patient’s necrotic bowel segments were resected followed by revascularization. Reoperation was performed in 32.3% of patients. Perioperative deaths were 41.9% and the overall mortality 58.1%.Conclusions: The findings of this study are not quite different from that performed on population living in normobaric oxygen environment except for a higher incidence of arterial thrombosis. Validation of these findings needs more standardized large prospective studies to avoid the impact of different confounding factors and the limited statistical power related to small sample sizes.
Study of morbidity pattern among geriatric patients attending outpatient department of a rural health training center, Maner of IGIMS, Patna
Authors: Kumari Seema , Bharati Dharmvir Ranjan , Yadava D. K. , . Shahin , Sinha Shivani , Kumari Anju 
Published: February 2019

Background: With increasing life expectancy, number of old age people increased throughout the world, particularly more in the developing countries like India. Globally there are an estimated 605 million people aged 60 years and above. As the ageing population is increasing, the burden of their health problems is on a rise. To provide appropriate care for them there is a need to attain information about their morbidity pattern. Objectives: to study the morbidity pattern among the geriatric patients attending outpatient department of RHTC, Maner of IGIMS, Patna and to find out the difference in health problems between males and females, if any.Methods: This hospital based cross-sectional study was conducted during September 2017 to February 2018 among 98 elderly patients, aged 60 years or above, who attended first time at the Out Patient Department of rural health training center, Maner of IGIMS, Patna and who fulfilled inclusion criterion.Results: In this study majority had normal nutritional status. Amongst morbidity, prevalence of locomotors problems was highest (63.26%) followed by depression (42.85%), refractive error (20.4%), hearing loss (18.2%) and cataract (15.3). Locomotors problems were significantly higher in women (93.75%) as compared to the men (34%). However, the prevalence of depression, refractory error, hearing loss and cataract were not significantly associated with gender.Conclusions: There is a need to deliver comprehensive geriatric health care services for prevention and control of chronic diseases and address the dual burden of disease among the elderly to promote healthy ageing.
Colonization and Development ofSirex noctilio(Hymenoptera: Siricidae) in Bolts of a Native Pine Host and Six Species of Pine Grown in the Southeastern United States
Authors: Bookwalter J.D. , Riggins J.J. , Dean J.F.D. , Mastro V.C. , Schimleck L.R. , Sullivan B.T. , Gandhi K.J.K. 
Published: February 2019

AbstractSirex noctilio F. (Hymenoptera: Siricidae) is a major exotic pest of pines (Pinus spp.) in the Southern Hemisphere and has become established in northeastern North America. We investigated the suitability of bolts of six economically and ecologically important U.S. pine species grown in the southeastern United States, including eastern white (P. strobus L.), loblolly (P. taeda L.), longleaf (P. palustris Miller), shortleaf (P. echinata Miller), slash (P. elliottii Engelmann), and Virginia (P. virginiana Miller) pines and its native Eurasian host, Scots pine (P. sylvestris L.), for S. noctilio reproduction. The properties of wood and resin of different pine species were also analyzed for possible correlates to S. noctilio's colonization and reproductive success on bolts. Sirex noctilio completed development on bolts within 4 mo of oviposition activities. Among the seven pine species, S. noctilio completed development in eastern white, Scots, and Virginia pines. Females tended to drill less on bolts with higher area and density of resin canals, as well as higher first 10-ring and radial stripspecific gravity. The resin of eastern white and Virginia pines had distinct extractive profiles, and eastern white pine may have two 3-carene chemotypes in the southeastern region.
Message from editor
Authors: Bayram Servet 
Published: February 2019

Dear Readers,

It is the great honour for us to publish the Eleventh Volume of World Journal on Educational Technology (WJET). WJET welcomes original empirical investigations and comprehensive literature review articles focusing on topics related to current issues of educational technology and interactive learning systems. WJET is a published quarterly and it is devoted to be a joint platform for presenting and discussing the emerging developments on educational technology issues in an international view.
Effect of Geological Layer Properties on Hydraulic-Fracture Initiation and Propagation: An Experimental Study
Authors: AlTammar Murtadha J. , Agrawal Shivam , Sharma Mukul M. 
Published: February 2019

Summary
Hydraulic-fracture initiation and propagation in the presence of multiple layers with different mechanical and flow properties are investigated experimentally using a novel fracturing cell. Mixtures of plaster, clay, and hydrostone are used to cast sheet-like and porous test specimens in layers with different configurations and properties. The layered specimens are hydraulically fractured under varying far-field differential stress. Fracture growth is recorded using a high-resolution digital camera. Key frames are subsequently analyzed using digital image correlation (DIC) to reveal microcracks, measure strains, and show other features such as shear-failure events that are difficult to detect with the naked eye.
The problem of a hydraulic fracture induced in a soft layer bounded by harder layers is considered. We demonstrate numerous laboratory experiments that reveal a clear tendency for induced fractures to avoid harder bounding layers. This is seen as fracture deflection or kinking away from the harder layers, fracture curving between the harder bounding layers, and fracture tilt from the maximum far-field stress direction. These observations appear to be more pronounced as the contrast in Young's modulus and fracture toughness between the layers increases and/or the far-field differential stress decreases. Moreover, when a fracture is induced in a relatively thin layer, the fracture avoids the harder bounding layers by starting and propagating parallel to the bounding interfaces. Fracture propagation parallel to the bounding layers is also observed in relatively wide layers when the far-field stress is isotropic or very low.
A fracture approaching a dipping, harder layer tends to curve away from the hard layer by kinking toward the high side of the interface. Nonplanar fracture trajectories are observed even in homogeneous materials when the far-field differential stress is relatively low. Furthermore, various other fracture behaviors in layered specimens are demonstrated and discussed, such as fracture offsetting at material interfaces, fracture branching and complex fracture trajectories, and shear failure of weakly bonded interfaces.
Influence of Pressure Difference Between Reservoir and Production Well on Steam-Chamber Propagation and Reservoir-Production Performance
Authors: Xiong Hao , Huang Shijun , Devegowda Deepak , Liu Hao , Li Hao , Padgett Zack 
Published: February 2019

Summary
Steam-assisted gravity drainage (SAGD) is the most-effective thermal recovery method to exploit oil sand. The driving force of gravity is generally acknowledged as the most-significant driving mechanism in the SAGD process. However, an increasing number of field cases have shown that pressure difference might play an important role in the process. The objective of this paper is to simulate the effects of injector/producer-pressure difference on steam-chamber evolution and SAGD production performance.
A series of 2D numerical simulations was conducted using the MacKay River and Dover reservoirs in western Canada to investigate the influence of pressure difference on SAGD recovery. Meanwhile, the effects of pressure difference on oil-production rate, stable production time, and steam-chamber development were studied in detail. Moreover, by combining Darcy's law and heat conduction along with a mass balance in the reservoir, a modified mathematical model considering the effects of pressure difference is established to predict the SAGD production performance. Finally, the proposed model is validated by comparing calculated cumulative oil production and oil-production rate with the results from numerical and experimental simulations.
The results indicate that the oil production first increases rapidly and then slows down when a certain pressure difference is reached. The pressure difference has strong effects on steam-chamber-rising/expansion stages. However, at the expansion stage, lower pressure difference can achieve the same effect as high pressure difference. In addition, it is shown that the steam-chamber-expansion angle is a function of pressure difference. Using this finding, a new mathematical model is established considering the modification of the expansion angle, which (Butler 1991) treated as a constant. With the proposed model, production performance such as cumulative oil production and oil-production rate can be predicted. The steam-chamber shape is redefined at the rising stage, changing from a fan-like shape to a hexagonal shape, but not the single fan-like shape defined by (Butler 1991). This shape redefinition can clearly explain why the greatest oil-production rate does not occur when the steam chamber reaches the caprock.
Literature surveys show few studies on how pressure difference influences steam-chamber development and SAGD recovery. The current paper provides a modified SAGD production model and an entirely new scope for SAGD enhanced oil recovery (EOR) that makes the pressure difference a new optimizable factor in the field.
Modeling of Liquid Injectivity in Surfactant-Alternating-Gas Foam Enhanced Oil Recovery
Authors: Gong J.. , Vincent-Bonnieu S.. , Kamarul Bahrim R. Z. , Che Mamat C. A. , Tewari R. D. , Groenenboom J.. , Farajzadeh R.. , Rossen W. R. 
Published: February 2019

SummarySurfactant alternating gas (SAG) is often the injection strategy used for injecting foam into a reservoir. However, liquid injectivity can be very poor in SAG, and fracturing of the well can occur. Coreflood studies of liquid injectivity directly following foam injection have been reported. We conducted a series of coreflood experiments to study liquid injectivity under conditions more like those near an injection well in a SAG process in the field (i.e., after a period of gas injection). Our previous experimental results suggest that the injectivity in a SAG process is determined by propagation of several banks. However, there is no consistent approach to modeling liquid injectivity in a SAG process. The Peaceman equation is used in most conventional foam simulators for estimating the wellbore pressure and injectivity.In this paper, we propose a modeling approach for gas and liquid injectivity in a SAG process on the basis of our experimental findings. The model represents the propagation of various banks during gas and liquid injection. We first compare the model predictions for linear flow with the coreflood results and obtain good agreement. We then propose a radial-flow model for scaling up the core-scale behavior to the field. The comparison between the results of the radial-propagation model and the Peaceman equation shows that a conventional simulator based on the Peaceman equation greatly underestimates both gas and liquid injectivities in a SAG process. The conventional simulator cannot represent the effect of gas injection on the subsequent liquid injectivity, especially the propagation of a relatively small region of collapsed foam near an injection well. The conventional simulator's results can be brought closer to the radial-flow-model predictions by applying a constant negative skin factor.The work flow described in this study can be applied to future field applications. The model we propose is based on a number of simplifying assumptions. In addition, the model would need to be fitted to coreflood data for the particular surfactant formulation, porous medium, and field conditions of a particular application. The adjustment of the simulator to better fit the radial-flow model also would depend, in part, on the grid resolution of the near-well region in the simulation.
Establishment of prediction score for hematoma expansion after intracerebral hemorrhage
Authors: Kong Xiangyu , Qian Wei , Dong Jun , Qian Zhiyuan 
Published: February 2019

Abstract
Background: Identification of intracerebral hemorrhage (ICH) patients at risk of hematoma expansion(HE) could facilitate the selection of candidates likely to benefit from therapies aiming to minimize ICH growth. We, therefore, aimed to develop a prediction score for HE that can be quickly used during the critical phase.
Methods: A retrospective analysis of clinical features of 317 ICH patients in the Second Affiliated Hospital of Soochow University from January, 2016 to May, 2018 was conducted. Independent risk factors of HE were obtained according to multiple logistic regression, and a prediction score was established and preliminarily evaluated.
Results: History of anticoagulants, ultraearly hematoma growth≥2.7ml/h, GCS≤8, and non-enhanced CT signs (island sign, black hole sign, blend sign, niveau formation) exist one or more, were independent risk factors for HE (P <0.05).The C statistics of score was 0.854 (95%CI, 0.803~0.904); P < 0.001); calibration was outstanding (c2=3.323, P = 0.344); decision curve analysis showed the score was safe and reliable, with high net benefit. After dichotomized, the sensitivity, specificity and accuracy of the high-risk group (score≥4.5) were 0.77, 0.85 and 0.83, respectively.
Conclusion The score can accurately identify high-risk individuals with HE, swift guide treatment decisions, and can also be used in clinical trials.
Keywords: Intracerebral hemorrhage; Hematoma expansion; Non-enhanced CT; Prediction; Score.
AS TEORIAS INSTITUCIONAIS E A FORMAÇÃO DO ESTADO BRASILEIRO
Authors: Andrade Ramá Lucas , Do Nascimento Mota João Luis 
Published: February 2019

A Nova Economia Institucional vai influenciar o pensamento político e social, a partir do pós-guerra e se fortalecer com a globalização, transformando-se em instrumento teórico para diversas outras ciências, como é o caso do Direito. Neste sentido, este artigo buscará compreender como as instituições e as teorias institucionais influenciaram a formação do Estado brasileiro. Para tal incursão é feito um estudo sobre as teorias institucionais e, em seguida, estuda a influência das instituições e do Institucionalismo para a formação do Estado brasileiro. Este artigo, do ponto de vista da abordagem do problema, foi tratado de forma qualitativa, em relação aos objetivos foi utilizado a pesquisa descritiva, do ponto de vista dos procedimentos técnicos foi realizada através de um estudo bibliográfico. No Brasil, a estrutura social está assentada em valores da racionalidade econômica. A autonomia da vontade privada e os pressupostos de liberdade e igualdade, anunciados pelo liberalismo e posteriormente pelo neoliberalismo, conduzem as relações sociais.
Optimization of tailings disposal method using fuzzy analytic hierarchy process
Authors: Naraghi Saeed , Masoumi Isa , Rashidinejad Farshad 
Published: February 2019

Abstract
Due to the increasing demand for metals, the extractable grade of metal deposits has been decreasing and caused an increase in the amount of tailings. Increase in the volume of tailings requires proper attention to tailings disposal, the establishment of tailings dams, water consumption and prevention of environmental and groundwater pollution. Since tailings disposal consists of many stages such as discharge, thickening technology and location, and transportation, selection of the best disposal method is a complicated task. Nowadays, decision-making methods are widely used and they are very reliable and efficient. Therefore, a model based on fuzzy analytic hierarchy process (AHP) has been developed in this study to optimize tailings disposal method selection. In the model, 21 criteria and a wide range of alternatives have been introduced. The model has been applied to the Sangan Iron Ore Project (SIOP). The concentrator plant of SIOP will produce 75 million tons of tailings during the mine lifetime. Since the current disposal method wastes 1.5 million cubic metres of water annually and the project is located in a dry region, the proposed model has been used to investigate other options and the results show the filtered technique is the best alternative.