bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teleonomy and the proximate–ultimate distinction revisited
Authors: Corning Peter A 
Published: May 2019

Abstract
It is now widely accepted that living systems exhibit an internal teleology (or teleonomy), but there are conflicting views about how this should be interpreted. Colin Pittendrigh and others have defined teleonomy broadly. It encompasses all ‘proximate’ (functional) biological phenomena. In contrast, Ernst Mayr and others would limit teleonomy to an a priori ‘program’ (the genome) and exclude proximate phenomena. I argue that living systems exhibit an ex post facto, means–ends teleonomy. Purposiveness is also a property of proximate functional phenomena. Mayr’s definition would also discount the causal role of teleonomy in shaping differential survival, i.e. natural selection and evolution. Proximate and ‘ultimate’ (evolutionary) causes are deeply interpenetrated. Going forward, we must integrate the various domains of causation better.
Raising awareness of unspecified living kidney donation: an ELPAT* view
Authors: Burnapp Lisa , Van Assche Kristof , Lennerling Annette , Slaats Dorthe , Van Dellen David , Mamode Nizam , Citterio Franco , Zuidema Willij , Weimar Willem , Dor Frank J M F 
Published: May 2019

AbstractBackgroundLiving donor kidney transplantation (LDKT) is the preferred treatment for patients with end-stage renal disease and unspecified living kidney donation is morally justified. Despite the excellent outcomes of LDKT, unspecified kidney donation (UKD) is limited to a minority of European countries due to legal constraints and moral objections. Consequently, there are significant variations in practice and approach between countries and the contribution of UKD is undervalued. Where UKD is accepted as routine, an increasing number of patients in the kidney exchange programme are successfully transplanted when a ‘chain’ of transplants is triggered by a single unspecified donor. By expanding the shared living donor pool, the benefit of LDKT is extended to patients who do not have their own living donor because a recipient on the national transplant list always completes the chain. Is there a moral imperative to increase the scope of UKD and how could this be achieved?MethodsAn examination of the literature and individual country practices was performed to identify the limitations on UKD in Europe and recommend strategies to increase transplant opportunities.ResultsPrimary limitations to UKD, key players and their roles and responsibilities were identified.ConclusionsRaising awareness to encourage the public to volunteer to donate is appropriate and desirable to increase UKD. Recommendations are made to provide a framework for increasing awareness and engagement in UKD. The public, healthcare professionals, policy makers and society and religious leaders have a role to play in creating an environment for change.
Mechanical circulatory support with the Impella 5.0 and the Impella Left Direct pumps for postcardiotomy cardiogenic shock at La Pitié-Salpêtrière Hospital
Authors: David Charles-Henri , Quessard Astrid , Mastroianni Ciro , Hekimian Guillaume , Amour Julien , Leprince Pascal , Lebreton Guillaume 
Published: May 2019

Abstract

OBJECTIVES
Postcardiotomy cardiogenic shock (PCCS) is associated with high mortality rates of 50–80%. Although veno-arterial extracorporeal membrane oxygenation has been used as mechanical circulatory support in patients with PCCS, it is associated with a high rate of complications and poor quality of life. The Impella 5.0 and Impella Left Direct (LD) (Impella 5.0/LD) are minimally invasive left ventricular assist devices that provide effective haemodynamic support resulting in left ventricular unloading and systemic perfusion. Our goal was to describe the outcome of patients with PCCS supported with the Impella 5.0/LD at La Pitié-Salpêtrière Hospital.

METHODS
We retrospectively reviewed consecutive patients supported with the Impella 5.0/LD for PCCS between December 2010 and June 2015. Survival outcome and in-hospital complications were assessed.

RESULTS
A total of 29 patients (63 ± 14 years, 17% women) with PCCS were supported with the Impella 5.0/LD. At baseline, 69% experienced chronic heart failure, 66% had dilated cardiomyopathy and 57% had valvular disease. The mean EuroSCORE II was 22 ± 17 and the ejection fraction was 28 ± 11%. Most of the patients underwent isolated valve surgery (45%) or isolated coronary artery bypass grafting (38%). The mean duration of Impella support was 9 ± 7 days. Weaning from the Impella was successful in 72.4%, and 58.6% survived to discharge. Recovery of native heart function was observed in 100% of discharged patients. Survival to 30 days and to 1 year from Impella implant was 58.6% and 51.7%, respectively.

CONCLUSIONS
The Impella 5.0 and the Impella LD represent an excellent treatment option for critically ill patients with PCCS and are associated with favourable survival outcome and native heart recovery.
The Association of a Single-Nucleotide Polymorphism in the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene With Adverse Drug Reactions, Multimorbidity, and Frailty in Older People
Authors: Scutt Greg , Overall Andrew , Bakrania Prijay , Krasteva Eliseveta , Parekh Nikesh , Ali Khalid , Davies J Graham , Rajkumar Chakravarthi 
Published: May 2019

Abstract
Susceptibility to adverse drug reactions (ADRs), multimorbidity, and frailty are associated with human aging, yet there is wide variation in the severity and age at which individuals are afflicted. Identifying genetic markers of increased risk of this phenotype would help stratify individuals to specialist interventions. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) regulates a cell’s response to stressors, including the expression of enzymes involved in drug metabolism. Its expression has been shown to decline in animal aging models. In this study, we tested the hypothesis that Nrf2 gene (NFE2L2) transcription/translation decline in human aging and that single-nucleotide polymorphisms (SNPs) in the NFE2L2 gene are associated with increased ADR risk, multimorbidity, and frailty in older people. Gene expression and protein levels were measured in peripheral blood mononuclear cells donated from healthy patients aged 18–80 years old. NFE2L2 genotypes were determined at three loci in a subpopulation of patients recruited to the PRIME study (a multicenter prospective cohort study that followed older adults for 8 weeks post-discharge to determine ADR). Both NFE2L2 gene and Nrf2 protein expression declined significantly with age in human peripheral blood mononuclear cells. In the PRIME substudy population, the rs35652124 NFE2L2 SNP was associated with increased ADR risk and decreased frailty and multimorbidity scores.
P-Glycoprotein–Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium
Authors: Arnold Samuel L M , Choi Ryan , Hulverson Matthew A , Whitman Grant R , Mccloskey Molly C , Dorr Carlie S , Vidadala Rama S R , Khatod Mansi , Morada Mary , Barrett Lynn K , Maly Dustin J , Yarlett Nigel , Van Voorhis Wesley C 
Published: May 2019

Abstract
Recent studies have illustrated the burden Cryptosporidium infection places on the lives of malnourished children and immunocompromised individuals. Treatment options remain limited, and efforts to develop a new therapeutic are currently underway. However, there are unresolved questions about the ideal pharmacokinetic characteristics of new anti-Cryptosporidium therapeutics. Specifically, should drug developers optimize therapeutics and formulations to increase drug exposure in the gastrointestinal lumen, enterocytes, or systemic circulation? Furthermore, how should researchers interpret data suggesting their therapeutic is a drug efflux transporter substrate? In vivo drug transporter–mediated alterations in efficacy are well recognized in multiple disease areas, but the impact of intestinal transporters on therapeutic efficacy against enteric diseases has not been established. Using multiple in vitro models and a mouse model of Cryptosporidium infection, we characterized the effect of P-glycoprotein efflux on bumped kinase inhibitor pharmacokinetics and efficacy. Our results demonstrated P-glycoprotein decreases bumped kinase inhibitor enterocyte exposure, resulting in reduced in vivo efficacy against Cryptosporidium. Furthermore, a hollow fiber model of Cryptosporidium infection replicated the in vivo impact of P-glycoprotein on anti-Cryptosporidium efficacy. In conclusion, when optimizing drug candidates targeting the gastrointestinal epithelium or gastrointestinal epithelial infections, drug developers should consider the adverse impact of active efflux transporters on efficacy.
Usefulness of a Novel System for Feedback of Patient-Reported Outcome Measures in Children Recovering From Burns
Authors: Riobueno-Naylor Alexa , Romo Stephanie , Kazis Lewis , Wang Shirley , Lydon Martha , Nelson Judith , Fowler Laura , Drexler Alana , Kogosov Ann , Haile Haregnesh , Ryan Colleen M , Chang Philip , Warner Petra , Palmieri Tina L , Lee Austin F , Stoddard Frederick , Murphy J Michael , Sheridan Robert L 
Published: May 2019

Abstract
The Burn Outcomes Questionnaire for children ages 5–18 years (BOQ5–18) is a widely used, reliable, and valid parent-reported outcome measure designed to assess children’s recovery from burn injuries in 12 physical and psychosocial domains. This study evaluated the feasibility, acceptability, and usefulness of a feedback system that delivered BOQ and Pediatric Symptom Checklist (PSC-17; a widely used measure of psychosocial functioning) results to burn care clinicians prior to an outpatient appointment or a postoperative surgical encounter. The BOQ and the PSC-17 were administered to the parents of 147 children receiving outpatient or surgical care in two pediatric burn hospitals. Clinician and parent perceptions of the feedback system were evaluated using debriefing questionnaires. Over half of all patients were at-risk on at least one BOQ subscale, and risk on three or more BOQ domains was significantly associated with a higher likelihood of poor psychological scores on the PSC-17 (P < .001). Significant differences in BOQ scores were found between the two hospital sites on four BOQ subscales, three related to physical ability and one to psychosocial well-being. Parent ratings of the feedback system were positive, with 90% of parents in both settings agreeing that the BOQ tablet experience was easy and helpful. Clinician attitudes differed across the two settings with more positive clinician ratings of the system in the outpatient setting (P < .001). Clinician interviews revealed that the data was especially useful in bringing to light psychosocial aspects of functioning relevant to long-term recovery from burn injuries.
Molecular Characterization of Primary Juvenile Hormone Responders Methoprene-Tolerant (Met) and Krüppel Homolog 1 (Kr-h1) in Grapholita molesta (Lepidoptera: Tortricidae) with Clarification of Their Roles in Metamorphosis and Reproduction
Authors: Zhang Jing , Liu Xiaoxia , Liu Yichen , An Yueqing , Fang Haibo , Michaud J P , Zhang Huaijiang , Li Yisong , Zhang Qingwen , Li Zhen 
Published: May 2019

AbstractMethoprene-tolerant (Met) is a putative JH intracellular receptor that transduces JH signal by activation of the inducible Krüppel homolog 1 (Kr-h1). We analyzed the gene sequences of Met and Kr-h1 and their patterns of expression in Grapholita molesta (Busck) immature and adult stages in order to better understand the roles of these primary JH responders in regulating the metamorphosis and reproduction of this global pest of fruit crops. The deduced amino acid sequences of both GmMet and GmKr-h1 were highly homologous to those of other Lepidoptera, especially the cotton bollworm, Helicoverpa armigera (Hubner) (Lepidoptera: Noctuidae). Peak expression of GmMet occurred during the last 3 to 5 d of the final instar, followed by that of GmKr-h1, in the last 3 d of final instar. Similar patterns of GmMet and GmKr-h1 expression were detected across various tissue types in the fifth-instar larvae, with the highest expression observed in the head, followed by the epidermis, and the fat body. When expression of GmMet and GmKr-h1 was knocked down via dsRNA injection in the fifth instar, the results were increased larval mortality, abnormal pupation, delayed pupal duration, reduced adult emergence, extended preoviposition period, and reduced fecundity. We infer that both GmMet and GmKr-h1 participated in regulation of metamorphosis and reproduction in G. molesta, the former acting upstream of the latter, and could present biorational targets for novel pest control compounds.
Decaying Organic Matter Does Not Remove Sublethal Effects of Imidacloprid on Mating in Spalangia endius (Hymenoptera: Pteromalidae), a Parasitoid of Filth Flies
Authors: Kremer A N , King B H 
Published: May 2019

Abstract
Both the parasitoid wasp Spalangia endius Walker and the insecticide imidacloprid are used to control house flies. A recent study found that negative sublethal effects of imidacloprid on killing flies and on offspring production by this parasitoid wasp are eliminated when females have the opportunity to crawl through decaying matter. An enzyme-linked immunosorbent assay showed that the presence of decaying matter reduces the amount of pesticide on their bodies. This study examined whether this was also true for sublethal effects on mating. S. endius were exposed to a realistic concentration of imidacloprid that induces very low mortality. Then, individual parasitoids were allowed to burrow through decaying organic matter or not, followed by mating tests in the absence of decaying matter. Even after 24 h with the decaying matter, copulation for both males and females that had previously been exposed to imidacloprid was delayed compared with no-pesticide controls. Furthermore, for pesticide-exposed males, subsequently burrowing through media made copulation even more delayed than if they were not exposed to media. For pesticide-exposed females, subsequently burrowing through media neither increased or decreased the negative effect of the pesticide exposure. Together with other studies, these results reinforce that use of S. endius and use of imidacloprid are incompatible, even at much lower than recommended concentration, unless application is sufficiently separated in place and time.
Inferring Biological Control Potential of Adult Predatory Coccinellids Using Life History Traits and Putative Habitat Preference
Authors: Jalali M Amin , Mehrnejad M Reza , Ellsworth Peter C 
Published: May 2019

Abstract
Aspects of the nutritional ecology and life histories of five predatory coccinellids (Coleoptera: Coccinellidae)—two arboreal predator species, Oenopia conglobata contaminata (Menetries) and Adalia bipunctata (Linnaeus), and three herbaceous dwelling predator species, Coccinella undecimpunctata aegyptica (Reiche), Exochomus nigripennis (Erichson), and Hippodamia variegata (Goeze) (Coleoptera: Coccinellidae)—were compared when fed either Agonoscena pistaciae Burckhardt and Lauterer (Hemiptera: Aphalaridae), the key psylla pest of pistachio trees, or Aphis gossypii Glover (Hemiptera: Aphididae), a common aphid on herbaceous plants in pistachio orchards. The putative habitat preferences of four of the five coccinellids studied were consistent with their performance on the major herbivore present in those two habitats in terms of net reproductive rate. Oenopia conglobata contaminata and Ad. bipunctata showed higher net reproductive rates when fed on pistachio psylla prey, whereas C. undecimpunctata aegyptiaca and E. nigripennis had better reproductive output on aphid prey. Moreover, E. nigripennis was the most specialized of these generalist predators, eating more and reproducing better when fed aphids. Hippodamia variegata was relatively unaffected by the diet offered, suggesting greater ability to switch among herbivore prey and perhaps better potential as a biocontrol agent with abilities to exploit Ag. pistaciae without large life history tradeoffs.
Governance of the Global Financial System: The Legitimacy of the BCBS 10 years after the 2008 Crisis
Authors: Prieto Muñoz Jose Gustavo 
Published: May 2019

ABSTRACT
This article explores the question of legitimacy that underpins Basel III. First, I present a general framework for assessing how legitimacy operates within the global financial system through an analysis of the internal and external dimensions. I next address the internal dimension, exploring the legitimacy of the Basel Committee on Banking Supervision (BCBS) as a body that exercises a type of public authority through the generation of norms/standards. I then analyse how the public law standards of transparency and accountability are currently being implemented within the BCBS system. Finally, I examine the external dimension, considering how the legitimacy of the BCBS is related to the international system. In particular, it is argued that because of the direct link between bailouts and human rights violations, the legitimacy of the BCBS is also tied to its role in promoting financial stability in the post-crisis architecture by protecting social rights within states.
Generic Ledipasvir-Sofosbuvir Treatment for Adolescents With Chronic Hepatitis C Virus Infection
Authors: Fouad Hanan M , Sabry Magda A , Ahmed Amal , Hassany Mohamed , Al Soda Mohamed F , Abdel Aziz Hossam 
Published: May 2019

Abstract
We assessed the safety and efficacy of a generic form of ledipasvir-sofosbuvir for the treatment of hepatitis C virus infection in Egyptian adolescents and compared the results with those of treatment with the brand-named form. The generic form resulted in a high response rate, significant improvement in liver function, and mild adverse effects. These results are comparable with those of the brand form at a reduced price.
Investigation of JAK2V617F Mutation Prevalence in Patients with Beta Thalassemia Major
Authors: Tahannejad Asadi Zari , Yarahmadi Reza , Saki Najmaldin , Jalali Mohammad Taha , Amin Asnafi Ali , Tangestani Raheleh 
Published: May 2019

AbstractBackgroundBeta (β)–thalassemia major is a genetic disorder with anemia and an increased level of erythropoietin by Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. JAK plays an important role in cell signaling, and the common mutation in the JAK2 gene in myeloid disorders is called JAK2V617F.MethodsA total of 75 patients with beta (β)-thalassemia major patients, including 34 males (45%) and 41 females (55%), were enrolled in this study. The presence of the JAK2V617F mutation was assessed using the amplification-refractory mutation–polymerase chain reaction (ARMS-PCR) technique.ResultsAmong the 75 patients, 14 patients (19%) tested positive and 61 patients (81%) tested negative for JAK2V617F mutation. We observed no statistically significant difference in sex, age, genotype, and JAK2V617F mutation among patients (P> .05). However, a significant difference between blood-transfusion frequency and JAK2V617F mutation was observed (P <.05).ConclusionDue to the low prevalence of JAK2V617F mutation in thalassemia, using a larger population of the patients to investigate this mutation in ineffective erythropoiesis can be useful.
Optical photometric variable stars towards Cygnus OB7
Authors: Dutta Somnath , Mondal Soumen , Joshi Santosh , Das Ramkrishna 
Published: May 2019

ABSTRACT
We present optical I-band light curves of the stars towards a star-forming region Cygnus OB7 from 17-night photometric observations. The light curves are generated from a total of 381 image frames with very good photometric precision. From the light curves of 1900 stars and their periodogram analyses, we detect 31 candidate variables including five previously identified. 14 out of 31 objects are periodic and exhibit the rotation rates in the range of 0.15–11.60 d. We characterize those candidate variables using optical/infrared colour–colour diagram and colour–magnitude diagram (CMD). From spectral indices of the candidate variables, it turns out that four are probably Classical T-Tauri stars (CTTSs), rest remain unclassified from present data, they are possibly field stars or discless pre-main-sequence stars towards the region. Based on their location on the various CMDs, the ages of two T Tauri Stars were estimated to be ∼5 Myr. The light curves indicate at least five of the periodic variables are eclipsing systems. The spatial distribution of young variable candidates on Planck 857 GHz (350 $\mu$m) and 2MASS (Two Micron All Sky Survey) Ks images suggest that at least two of the CTTSs are part of the active star-forming cloud Lynds 1003.
Pseudouridines on Trypanosoma brucei spliceosomal small nuclear RNAs and their implication for RNA and protein interactions
Authors: Rajan K Shanmugha , Doniger Tirza , Cohen-Chalamish Smadar , Chen Dana , Semo Oz , Aryal Saurav , Glick Saar Efrat , Chikne Vaibhav , Gerber Doron , Unger Ron , Tschudi Christian , Michaeli Shulamit 
Published: May 2019

Abstract
The parasite Trypanosoma brucei, the causative agent of sleeping sickness, cycles between an insect and a mammalian host. Here, we investigated the presence of pseudouridines (Ψs) on the spliceosomal small nuclear RNAs (snRNAs), which may enable growth at the very different temperatures characterizing the two hosts. To this end, we performed the first high-throughput mapping of spliceosomal snRNA Ψs by small RNA Ψ-seq. The analysis revealed 42 Ψs on T. brucei snRNAs, which is the highest number reported so far. We show that a trypanosome protein analogous to human protein WDR79, is essential for guiding Ψ on snRNAs but not on rRNAs. snoRNA species implicated in snRNA pseudouridylation were identified by a genome-wide approach based on ligation of RNAs following in vivo UV cross-linking. snRNA Ψs are guided by single hairpin snoRNAs, also implicated in rRNA modification. Depletion of such guiding snoRNA by RNAi compromised the guided modification on snRNA and reduced parasite growth at elevated temperatures. We further demonstrate that Ψ strengthens U4/U6 RNA–RNA and U2B"/U2A’ proteins-U2 snRNA interaction at elevated temperatures. The existence of single hairpin RNAs that modify both the spliceosome and ribosome RNAs is unique for these parasites, and may be related to their ability to cycle between their two hosts that differ in temperature.
Proteomics and metabolomics studies exploring the pathophysiology of renal dysfunction in autosomal dominant polycystic kidney disease and other ciliopathies
Authors: Zacchia Miriam , Marchese Emanuela , Trani Elena Martina , Caterino Marianna , Capolongo Giovanna , Perna Alessandra , Ruoppolo Margherita , Capasso Giovambattista 
Published: May 2019

Abstract
The primary cilium (PC) was considered as a vestigial organelle with no significant physiological importance, until the discovery that PC perturbation disturbs several signalling pathways and results in the dysfunction of a variety of organs. Genetic studies have demonstrated that mutations affecting PC proteins or its anchoring structure, the basal body, underlie a class of human disorders (known as ciliopathies) characterized by a constellation of clinical signs. Further investigations have demonstrated that the PC is involved in a broad range of biological processes, in both developing and mature tissues. Kidney disease is a common clinical feature of cilia disorders, supporting the hypothesis of a crucial role of the PC in kidney homoeostasis. Clinical proteomics and metabolomics are an expanding research area. Interestingly, the application of these methodologies to the analysis of urine, a biological sample that can be collected in a non-invasive fashion and possibly in large amounts, makes these studies feasible also in patients. The present article describes the most recent proteomic and metabolomic studies exploring kidney dysfunction in the setting of ciliopathies, showing the potential of these methodologies in the elucidation of disease pathophysiology and in the discovery of biomarkers.