bluuebunny/crossref_metadata_2025_split huggingface dataset:
Existence of global solutions in a model of electrical activity of the monodomain type for a ventricle
Authors: Hernández Montero Ozkar , Fraguela Collar Andrés , Felipe Sosa Raúl 
Published: July 2018

Introduction: A monodomain model of electrical activity for an isolated ventricle is formulated. This model is written as a reaction diffusion PDE coupled to an ODE, The Rogers-Mculloch model is used to represent the electrical activity through the cell membrane. Method: We give a definition of weak and strong solution of the variational Cauchy problem associated to the monodomain model. A sequence of approximate solutions of Faedo-Galerkin type is proposed.Results: It is shown that the sequence of approximate solutions converge to a weak solution according to the proposed definition. Finally, we have that this weak solution is also a strong solution. Conclusion: The monodomain model of electrical activity in an isolated ventricle that is proposed has a weak solution in an appropriate sense. In addition, this weak solution is also a strong solution.
Graphene Modified Molecular Imprinting Electrochemical Sensor for Determining the Content of Dopamine
Authors: Liu Rong , Li Jie , Zhong Tongsheng , Long Liping 
Published: July 2018

Background:
The unnatural levels of dopamine (DA) result in serious neurological disorders
such as Parkinson’s disease. Electrochemical methods which have the obvious advantages of
simple operation and low-cost instrumentation were widely used for determination of DA. In order to
improve the measurement performance of the electrochemical sensor, molecular imprinting technique
and graphene have always been employed to increase the selectivity and sensitivity.

Methods:
An electrochemical sensor which has specific selectivity to (DA) was proposed based on the
combination of a molecular imprinting polymer (MIP) with a graphene (GR) modified gold electrode.
The performance and effect of MIP film were investigated by differential pulse voltammetry (DPV)
and cyclic voltammetry (CV) in the solution of 5.0 ×10-3 mol/L K3[Fe(CN)6] and K4[Fe(CN)6] with
0.2 mol/L KCl at room temperature.

Results:
This fabricated sensor has well repeatability and stability, and was used to determine the dopamine
of urine. Under the optimized experiment conditions, the current response of the imprinted
sensor was linear to the concentration of dopamine in the range of 1.0×10-7 ~ 1.0×10-5 mol/L, the linear
equation was I (µA) = 7.9824+2.7210lgc (mol/L) with the detection limit of 3.3×10-8 mol/L.

Conclusion:
In this work, a highly efficient sensor for determination of DA was prepared with good
sensitivity by GR and great selectivity of high special recognization ability by molecular imprinting
membrane. This proposed sensor was used to determine the dopamine in human urine successfully.
Electrochemical Detector for Liquid Chromatography: Determining Minoxidil in Hair-Growth Pharmaceuticals
Authors: Wang Lai-Hao , Cheng Pei-Tung 
Published: July 2018

Background:
The electrochemical behavior of minoxidil on gold (Au), Glassy Carbon (GCEs),
and Carbon Paste Electrodes (CPEs) was investigated in an aqueous supporting electrolyte (phosphate
buffer [pH 2.0-6.5], acetate buffer [pH 4.3], and Britton and Robinson buffer [pH 2.0-7.4]).

Methods:
For cyclic voltammetric measurements with suitable methodical parameters, CPEs catalyze
electrooxidation of minoxidil more efficiently than do other electrodes. Minoxidil was detected using
high-performance liquid chromatography with an electrochemical (carbon paste) detector (HPLCECD).
For direct current mode, with the current at a constant potential, and measurements with suitable
experimental parameters, a linear concentration from 0.02 to 2.6 mg L-1 was found. The detection
limit was approximately 20 ng m L-1.

Results:
The developed method detected minoxidil samples.

Conclusion:
Findings using HPLC-ECD and HPLC with an ultraviolet detector were comparable.
A Validation and Estimation of Total Eicosapentaenoic and Docosahexaenoic acids Using LC-MS/MS with Rapid Hydrolysis Enzymatic Method for Hydrolysis of Omega Lipids in Human Plasma and its Application in the Pharmacokinetic Study
Authors: Viswanathan Sekarbabu , Verma Priya Ranjan Prasad , Ganesan Muniyandithevar 
Published: July 2018

Background:In this study, we have developed a novel, rapid enzymatic hydrolysis method for conversion of omega lipids (omega fatty acid triglycerides, phospholipids, omega conjugates) in to free fatty acids at room temperature using lipase and esterase enzymes. </P><P> Objective: To develop simple enzymatic hydrolysis and rapid sample extraction method for quantification of free (un-esterified) and conjugated (esterified) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to provide the total EPA and DHA lipids present in human plasma. Quantification of total EPA/DHA was performed using liquid chromatography and tandem mass spectrometer instrument.Methods:The plasma sample is digested with lipase and esterase enzymes and extracted by using combined precipitation and liquid-liquid techniques. The LC-MS/MS method was optimized using EPA-D5 and DHA-D5 as labeled internal standards for EPA/DHA respectively. The analytical method is validated, utilized for simultaneous quantification of total EPA and DHA lipids in plasma collected from healthy human volunteers clinical study.Results:The reproducibility of the established enzymatic hydrolysis method was demonstrated by incurred sample reanalysis and the results for total EPA and DHA lipid were 93.33% and 96.67% respectively. The pharmacokinetic and statistical analysis was performed using baseline corrected concentration of total EPA and DHA lipids.Conclusion:The enzymatic hydrolysis method for conversion of omega fatty acid triglycerides, phospholipids, omega conjugates in to free fatty acid was reported first time for the quantitative application. The shorter time for sample workup procedure, simple enzymatic hydrolysis at room temperature and 3 minutes chromatography run time are well suitable for bioavailability/ bioequivalence studies.
STEVIA AN UNTOUCHED NATURE’S GIFT CAN BE A BOON TO DIABETIC
Authors: Walia Ramanpreet , Verma Abhay 
Published: July 2018

Plants and fungi are a vital part of healthcare. Over 80% of the global population rely on traditional medicine, much of which is based on plant remedies. Traditional Chinese medicine alone uses over 5,000 plant species.
There is a healing quality in nature, which has been known for centuries, be it taking time to smell the roses, meditating on a mountain, lying in a wildflower field, strolling by a meandering stream, or hiking in ancient redwood groves. Hippocrates, the father of modern medicine, recognized this powerful attribute in his humbling statement:
Nature cures—not the physician. Hippocrates
PROJECT MANAGEMENT VALUES DRIVEN IN PHARMA INDUSTRY
Authors: Tripathy Swagat , Mohanty Bishnu B. 
Published: July 2018

In the pharmaceutical industry, project management is key to addressing the unique regulatory, compliance and quality related needs of the industry. As the process of drug development and the critical issue of time to market can capitalize on project management techniques to effectively apply scheduling, risk management, and comprehensive quality assurance and control to the process of bringing a drug to market in a cost-effective but safe way.
“JUST DO IT” is the approach that XYZ Generic Company was using before this project arrives.
Disclaimer statement: The writing and views expressed are those of purely of author’s personal view and is not related to the organization, where authors are working.
The Bard on the Banks of Dulung Sings: Conversation with Jaydeep Sarangi
Authors: Singh Ruchi 
Published: July 2018

Jaydeep Sarangi is a bilingual writer, academic, editor, interviewer, translator and author of a number of significant publications on postcolonial issues, Indian writing in English, Australian literature, marginal literatures and creative writing, in journals and magazines both in India and abroad. He is on the editorial board of several refereed journals in different continents. Widely anthologised and reviewed as a poet and a critic on marginal writings. He has authored and edited many books. I was prompted to interview him after reading his collection of poems titled "Faithfully, I Wait: Poems on rain, thunder and lightning at Jhargram and Beyond." I conducted this interview via a series of e-mails in the month of February.
GROWTH RESPONSE OF Ganoderma sp. MYCELIUM TREATED WITH ROOT EXUDATES OF HERBACEOUS PLANTS
Authors: Rahmadhani Tiara Putri , Suwandi Suwandi , Pujiastuti Yulia 
Published: July 2018

The purpose of the study was to study response of Ganoderma sp. that were given exudate treatment of plant roots. Ganoderma sp. is a pathogen that causes stem rot at base of oil palm. In addition to oil palm this fungus can attack hard and woody crops such as coconut, rubber, tea, cocoa etc. Isolate used is Ganoderma sp. Bio-10197 code obtained from Phytopathology laboratory SEAMEO BIOTROP Bogor. Mycelium Ganoderma sp. reproduced in malt agar media until mycelium grows over agar surface. Ganoderma mycelium was inoculated on 1x1x5 cm rubber wood pieces for 14 days until the mycelium grew over rubber sticks. The exudate used from ganyong (Canna edulis Kerr), garut (Maranta arundinacea Linn.), Ginger (Zingiber officinale Rosc.), Turmeric (Curcuma domestica Val.), Galangal (Alpinia galanga (L.) Sw.) and lidah mertua (Sansevieria trifasciata). The design used in this study was a complete randomized design (RAL) with 7 treatments consisting of 5 repeatations. The results of this study indicate that the mycelium experienced inhibition of growth, especially in the treatment of root exudate galangal shown by 60,81% percentage and tongue-in-law with a percentage of 59,58% colonization. On observation of growth characteristics of mycelium Ganoderma sp. visible zone delimited in the form of a brown mycelium pile suspected as an indication of mycelium rejection of bioactive compounds contained exudate.
Eğitilebilir Zihinsel Engelli Çocukların Besin Tüketim Kayıtlarına Göre Beslenme Durumları
Authors: ÖZBAŞ Serpil , USKUN Ersin , KÜÇÜKSOKU Büşra , HOCAOĞLU Ümmü , AKALIN Sümeyra , ÖZBAŞ Halil 
Published: July 2018

Bu çalışmada
eğitilebilir zihinsel engelli çocukların beslenme durumlarının besin tüketim
kayıtları kullanarak belirlenmesi ve temel besin öğelerinin alımındaki
eksiklikleri veya fazlalıkların tespit edilmesi amaçlanmıştır. Eğitilebilir
zihinsel engelli 45 öğrencinin 3 gün boyunca tükettiği bütün besin maddelerini besin
tüketim kaydı formuna kaydedildi. Kayıtları tam ve doğru olan 32 kişi değerlendirmeye
alınmıştır. Her çocuğun aldığı enerji, protein, vitamin ve minerallerin
miktarları hesaplanmıştır. Besin maddelerinin alımı çocuğun yaşına ve
cinsiyetine göre değerlendirilmiştir. Çocukların %43.8’inde beslenme ile ilgili
sorun olduğu, %28.1’inin öğün atladığı belirlenmiştir. Çocukların %90.6’sının
ana öğünler dışında ara öğün tükettiği belirlenmiş ve çocukların alması gereken
enerjiden günlük ortalama 1004±435 kkal daha fazla enerji aldığı tespit
edilmiştir. Zihinsel engelli çocuklarda özellikle şekerli gıdalara aşırı
yönelim ve tüketimi sağlıklı büyüme gelişme için gerekli olan elementlerin
karşılanamaması ve aşırı zayıflık ya da obeziteye neden olabilmektedir.
Zihinsel engelli çocukların beslenme sorunlarının çözümünde bireysel
özelliklere göre yaklaşım sağlanmalıdır.
From daily land-use practice to global phenomenon. On the origin and recent evolution of prosecco’s wine landscape (Italy)
Authors: Basso Matteo 
Published: July 2018

Abstract
In recent years Prosecco, the renowned Italian sparkling wine, has become an increasingly popular product globally, leading to a massive expansion of viticulture within Prosecco’s production zones (north-eastern Italy).
Through qualitative and quantitative methods, this paper provides the first empirical analysis of the landscape and land-use modifications generated by the planting of new vineyards. Specifically, it seeks to reconstruct both the long-term historical factors that brought about the emergence of the specific winescape (today a candidate for becoming a UNESCO World Heritage Site), and the recent conversion of croplands, grassland, and woodland to wine-growing areas. The landscape, particularly on the plains, is radically changing due to the new, large geometric plantations that are perfectly suited to mechanical viticulture.
This paper’s conclusions argue for overall regulation of such a booming monoculture in order to effectively harmonize the production needs of wine-growers with the needs of other land-uses (mostly residential), and to protect the historical landscape patterns and ecological biodiversity.
Psychological Readiness to Return to Sport Is Associated With Knee Kinematic Asymmetry During Gait Following Anterior Cruciate Ligament Reconstruction
Authors: Zarzycki Ryan , Failla Mathew , Capin Jacob J. , Snyder-Mackler Lynn 
Published: July 2018

Background Gait asymmetry is frequently observed following anterior cruciate ligament reconstruction (ACLR). Psychological readiness to return to sport is associated with functional and activity-related outcomes after ACLR. However, the association between gait asymmetry and psychological readiness to return to sport is unknown. Objectives To determine the relationship between kinematic and kinetic measures of knee symmetry during gait and psychological readiness to return to sport following ACLR. Methods In this controlled laboratory, cross-sectional study, 79 athletes (39 women) underwent gait analysis following impairment resolution after ACLR (ie, full range of motion, minimal or no effusion, quadriceps strength index of 80% or greater). Interlimb differences during gait were calculated for sagittal plane knee angles at initial contact, peak knee flexion, and peak knee extension, as well as for peak knee flexion moment and peak knee adduction moment. Athletes completed the Anterior Cruciate Ligament-Return to Sport after Injury scale (ACL-RSI) to assess psychological readiness to return to sport. Pearson correlations were used to examine the association between ACL-RSI score and each gait symmetry variable. Results Significant negative correlations were observed between the ACL-RSI and 2 kinematic variables: knee flexion angle at initial contact (r = −0.281, P = .012) and peak knee flexion (r = −0.248, P = .027). In general, lower scores on the ACL-RSI were associated with greater interlimb asymmetry. Conclusion There was a weak association between psychological readiness to return to sport and knee kinematic asymmetry during gait. J Orthop Sports Phys Ther 2018;48(12):968–973. Epub 27 Jul 2018. doi:10.2519/jospt.2018.8084
Rehabilitation of an Adolescent Equestrian Athlete With a History of Multiple Concussions: A Case Report Describing an Adapted Return-to-Sport Protocol
Authors: Gunter Kelli B. , Shields Christopher J. , Ott Summer D. , Coronado Rogelio A. 
Published: July 2018

Background Equestrian riding is a sport with a high risk of concussion. Currently, the literature guiding rehabilitation for concussions in equestrian athletes is limited, especially for directing return to sport. Case Description In this case report, a 14-year-old female equestrian athlete presented to physical therapy following her third concussion in 3 years. Her primary complaints were headaches, dizziness, difficulty concentrating, light sensitivity, and neck pain. On examination, the patient demonstrated reproduction of symptoms during testing of the vestibular-ocular reflex, showed a 3-line symptomatic loss on the dynamic visual acuity test, and had impairments in the joint position error test (1/5 correct on the left, 4/5 correct on the right) and a Balance Error Scoring System (BESS) score of 38/60 errors. A return-to-riding protocol was adapted from general return-to-sport guidelines and tailored to meet the unique demands of the patient's equestrian sport. The protocol included phased progression through no activity, light aerobic activity, moderate aerobic activity, sport-specific nonjumping skills, sport-specific jumping skills, full practice, and return to competition. During the protocol, the patient participated in 8 physical therapy sessions over 4 weeks for vestibular training, aerobic conditioning, and cervical and core exercises, as well as equestrian exercises at her stables. Outcomes At the final evaluation, the patient reported no symptoms at rest, with exercise, or when testing vestibular-ocular reflex. Improvements were noted in the dynamic visual acuity test, joint position error, and BESS, with changes in the BESS exceeding minimal detectable change. The patient completed the full return-to-riding protocol in 8 weeks and was able to return to equestrian competition without complaints. Discussion This case report describes the physical therapy management of an adapted return-to-sport protocol for an equestrian athlete with a history of multiple sport-related concussions. Level of Evidence Therapy, level 5. J Orthop Sports Phys Ther 2018;48(12):934–942. Epub 27 Jul 2018. doi:10.2519/jospt.2018.8214
Changes in Measures of Cervical Spine Function, Vestibulo-ocular Reflex, Dynamic Balance, and Divided Attention Following Sport-Related Concussion in Elite Youth Ice Hockey Players
Authors: Schneider Kathryn J. , Meeuwisse Willem H. , Palacios-Derflingher Luz , Emery Carolyn A. 
Published: July 2018

Background Concussion is a commonly occurring injury. The extent to which the cervical spine, vestibulo-ocular reflex (VOR), dynamic balance, and divided attention are affected following concussion is not well understood. Objectives To evaluate acute changes in measures of (1) cervical spine function, (2) VOR function, (3) dynamic balance, and (4) tasks of divided attention in elite youth ice hockey players following a sport-related concussion. Methods In this prospective cohort study, elite 13- to 17-year-old ice hockey players completed cervical spine measures (cervical flexor endurance test, head perturbation test, anterolateral strength, cervical flexion rotation test, joint position error), VOR function tests (head thrust test, dynamic visual acuity [clinical and computerized]), dynamic balance tests (Functional Gait Assessment), and divided-attention tasks (walking-while-talking test) both in the preseason and following concussion. Results At least 1 test was completed by 69 of 97 (71%) players (a maximum of 55 for any 1 test) at both preseason and immediately following concussion (median, 4 days post concussion). After Bonferroni corrections (α = .00625), using Wilcoxon signed-rank tests, cervical spine measures were significantly worse following concussion compared to baseline (cervical flexor endurance test: z = −5.20, P<.001; anterolateral neck strength: zleft = −5.36, P<.001 and zright = −5.45, P<.001; and head perturbation test: z = −4.36, P<.001). Time taken to complete a complex task of divided attention relative to normal walking speed was faster (improved) compared to the preseason (z = −2.59, P<.01). There was no change in VOR or dynamic balance following concussion. Conclusion Measures of cervical spine function and divided attention were altered following concussion. However, tests of VOR and dynamic balance were not significantly different from baseline. Future research to evaluate the mechanism underlying these changes is warranted. J Orthop Sports Phys Ther 2018;48(12):974–981. Epub 27 Jul 2018. doi:10.2519/jospt.2018.8258
Self-reported Home Exercise Adherence: A Validity and Reliability Study Using Concealed Accelerometers
Authors: Nicolson Philippa J.A. , Hinman Rana S. , Wrigley Tim V. , Stratford Paul W. , Bennell Kim L. 
Published: July 2018

Background Accurate measurement of adherence to prescribed exercise programs is essential. Diaries and self-report rating scales are commonly used, yet little evidence exists to demonstrate their validity and reliability. Objectives To examine the concurrent validity of adherence to home strengthening exercises measured by (1) exercise diaries and (2) a self-report rating scale, compared to adherence measured using an accelerometer concealed in an ankle cuff weight. Test-retest reliability of the self-report rating scale was also assessed. Methods In this clinical measurement study, 54 adults aged 45 years or older with self-reported chronic knee pain were prescribed a home quadriceps-strengthening program. Over 12 weeks, participants completed paper exercise diaries and, at appointments every 2 weeks, rated their adherence on an 11-point numeric rating scale. A triaxial accelerometer was concealed in the ankle cuff weight used for exercises. Self-reported adherence rating scale data over each 2-week period were analyzed using descriptive statistics, the Wilcoxon signed-rank test, and a Bland-Altman plot to assess agreement, Spearman correlations for validity, and intraclass correlation coefficients for test-retest reliability. Results Exercise adherence was significantly overestimated in diaries during the 12 weeks (diary median, 220 exercises; accelerometer, 176; P<.001) and was moderately correlated with accelerometer data (r = 0.52; 95% confidence interval: 0.26, 0.69). A Bland-Altman plot indicated large between-participant variability in agreement between these measures. Self-reported adherence showed poor to fair correlations with accelerometer data (mean r = 0.23–0.39), and less than acceptable reliability (intraclass correlation coefficient = 0.79; lower 1-sided 95% confidence limit, 0.68). Conclusion Exercise diaries showed questionable validity and variable levels of agreement compared with accelerometer-measured exercise completion. A self-reported adherence rating scale had limited validity and less than acceptable test-retest reliability. J Orthop Sports Phys Ther 2018;48(12):943–950. Epub 27 Jul 2018. doi:10.2519/jospt.2018.8275
Clinical Predictors of Dynamic Lower Extremity Stiffness During Running
Authors: Goodwin Jonathan S. , Blackburn J. Troy , Schwartz Todd A. , Williams D.S. Blaise 
Published: July 2018

Background Lower extremity stiffness describes the relative loading and kinematics of the entire lower extremity during ground contact. Previously injured subjects demonstrate altered lower extremity stiffness values. Clinical analysis of lower extremity stiffness is not currently feasible due to increased time and cost. Objective To determine the clinically identifiable contributors to lower extremity stiffness. Methods In this cross-sectional controlled laboratory study, 92 healthy runners completed a clinical screening involving passive assessment of hip, knee, and ankle range of motion, along with body anthropometrics. The range of motion was predominantly assessed in the sagittal and frontal planes. In the same session, runners completed an overground kinematic and kinetic running assessment at 3.35 m/s (±5%) to obtain lower extremity stiffness. Correlations between lower extremity stiffness and clinical variables were completed. Modifiable variables were included in an all-possible-linear regressions approach to determine a parsimonious model for predicting lower extremity stiffness. Results Clinically modifiable measures included in the regression model accounted for 48.4% of the variance of lower extremity stiffness during running. The variables that predicted greater stiffness included greater body mass, less ankle dorsiflexion range of motion with the knee flexed, less hip internal rotation range of motion, and less first-ray mobility. Conclusion Reduced lower extremity range of motion and greater body mass are associated with greater lower extremity stiffness during running. These variables could be addressed clinically to potentially alter lower extremity stiffness and injury risk. J Orthop Sports Phys Ther 2019;49(2):98–104. Epub 27 Jul 2018. doi:10.2519/jospt.2019.7683