bluuebunny/crossref_metadata_2025_split huggingface dataset:
The VGCC auxiliary subunit α2δ1 is an extracellular GluA1 interactor and regulates LTP, spatial memory, and seizure susceptibility
Authors: Leana-Sandoval Gerardo , Kolli Ananth V. , Sandoval Matthew A. , Saavedra Emily , Li Kathy H. , Chen Lulu Y. , Burlingame Alma L. , Ramírez-Franco Jorge , Díaz-Alonso Javier 
Published: December 2024

AbstractActivity-dependent synaptic accumulation of AMPA receptors (AMPARs) and subsequent long-term synaptic strengthening underlie different forms of learning and memory. The AMPAR subunit GluA1 amino-terminal domain is essential for synaptic docking of AMPAR during LTP, but the precise mechanisms involved are not fully understood. Using unbiased proteomics, we identified the epilepsy and intellectual disability-associated VGCC auxiliary subunit α2δ1 as a candidate extracellular AMPAR slot. Presynaptic α2δ1 deletion in CA3 affects synaptic AMPAR incorporation during long-term potentiation, but not basal synaptic transmission, at CA1 synapses. Consistently, mice lacking α2δ1 in CA3 display a specific impairment in CA1-dependent spatial memory, but not in memory tests involving other cortical regions. Decreased seizure susceptibility in mice lacking α2δ1 in CA3 suggests a regulation of circuit excitability by α2δ1/AMPAR interactions. Our study sheds light on the regulation of activity-dependent AMPAR trafficking, and highlights the synaptic organizing roles of α2δ1.Significance statementActivity-dependent accumulation of AMPA receptors (AMPARs) at excitatory synapses and subsequent synaptic strengthening underlies long-term potentiation (LTP), forms of learning and memory, and some epilepsies. The “slot model” posits that postsynaptic scaffolding contain “slots” for AMPAR complexes, and that increased synaptic activity augments the availability of slots to accommodate more receptors, thereby strengthening synapses and enabling LTP. The presence of the GluA1 AMPAR subunit amino-terminal domain (ATD) has recently emerged as an additional requirement for LTP. Here we identify the auxiliary voltage-gated calcium channel subunit α2δ1 as a GluA1 ATD interacting protein and provide evidence supporting a role for α2δ1 as an extracellular AMPAR slot regulating activity dependent synaptic AMPAR clustering, excitability, and cognitive function.
Decoding task representations that support generalization in hierarchical task
Authors: Lee Woo-Tek , Hazeltine Eliot , Jiang Jiefeng 
Published: December 2024

AbstractTask knowledge is encoded hierarchically such that complex tasks are composed of simpler tasks. This compositional organization also supports generalization to facilitate learning of related but novel complex tasks. To study how the brain implements composition and generalization in hierarchical task learning, we trained human participants on two complex tasks that shared a simple task and tested them on a novel complex task whose composition could be inferred via the shared simple task. Behaviorally, we observed faster learning of the novel complex task than control tasks (i.e., behavioral generalization effect). Using electroencephalogram (EEG) data, we could decode the constituent simple tasks when a complex task was performed (i.e., EEG composition effect). Crucially, the shared simple task, although not part of the novel complex task, could be reliably decoded from the novel complex task. The decoding strength was also correlated with EEG composition effect and behavioral generalization effect. The findings demonstrate how generalization in task learning is implemented via task reinstatement.Significance StatementHumans can generalize knowledge of existing tasks to accelerate the learning of new tasks. We hypothesize that generalization is achieved by decomposing a complex task into simple (sub)tasks and reusing the simple tasks to infer the structure of a new complex task and build it. Using electroencephalogram data, we showed that constituent simple tasks can be decoded from of humans learning new complex tasks. Crucially, when the structure of a new complex task can be inferred from simple tasks, the simple tasks can be decoded from the new complex task, even when they are not part of the new complex task. These findings demonstrate the importance of the reinstatement of simple tasks in task learning through generalization.
Molecular evolution of a reproductive barrier in maize and related species
Authors: Cryan Elli , Phinney Garnet , Seetharam Arun S. , Evans Matthew M.S. , Kellogg Elizabeth A. , Zhan Junpeng , Meyers Blake C. , Kliebenstein Daniel J. , Ross-Ibarra Jeffrey 
Published: December 2024

AbstractThree cross-incompatibility loci each control a distinct reproductive barrier in both domesticated maize (Zea maysssp.mays) and its wild teosinte relatives. These three loci,Teosinte crossing barrier1(Tcb1),Gametophytic factor1(Ga1), andGa2, each play a key role in preventing hybridization between incompatible populations and are proposed to maintain the barrier between domesticated and wild subspecies. Each locus encodes both a silk-active and a matching pollen-active pectin methylesterase (PMEs). To investigate the diversity and molecular evolution of these gametophytic factor loci, we identified existing and improved models of the responsible genes in a new genome assembly of maize line P8860 that contains active versions of all three loci. We then examined fifty-two assembled genomes from seventeen species to classify haplotype diversity and identify sites under diversifying selection during the evolution of these genes. We show thatGa2, the oldest of these three loci, was duplicated to formGa1at least 12 million years ago.Tcb1, the youngest locus, arose as a duplicate ofGa1before or around the time of diversification of theZeagenus. We find evidence of positive selection during evolution of the functional genes at an active site in the pollen-expressed PME and predicted surface sites in both the silk- and pollen-expressed PMEs. The most common allele at theGa1locus is a conservedga1allele (ga1-Off), which is specific haplotype containing three full-length PME gene copies, all of which are non-coding due to conserved stop codons and are between 610 thousand and 1.5 million years old. We show that thega1-Offallele is associated with and likely generates 24-nt siRNAs in developing pollen-producing tissue, and these siRNAs map to functionalGa1alleles. In previously-published crosses, thega1-Offallele was associated with reduced function of the typically dominant functional alleles for the Ga1 and Tcb1 barriers. Taken together, this seems to be an example of a type of epigenetic trans-homolog silencing known as paramutation functioning at a locus controlling a reproductive barrier.
Being left behind: disclosure strategies to manage the Juukan Gorge cave blast
Authors: Kaur Amanpreet , Lodhia Sumit , Lesue Alexander 
Published: December 2024

PurposeThis study aims to investigate how disclosures through different communication media were used by the Australian mining company Rio Tinto to manage its reputation after the Juukan Gorge Cave Blast.Design/methodology/approachCase study research was used with a focus on a single case, Rio Tinto and the Juukan Gorge incident. Data on sustainability disclosures were collected from Rio Tinto’s website, corporate reports and social media platforms (Facebook, X and LinkedIn) for the 2020 and 2021 periods. Gioia methodology was applied to analyse disclosure strategies and an extended Reputation Risk Management (RRM) framework was used as a conceptual lens.FindingsThe findings reveal a slow and inappropriate initial response from the company resulting in negative reputational consequences for the company’s senior executives. Although the company’s initial response was to avoid responsibility and mitigate offensiveness, it gradually accepted full responsibility and adopted reparation strategies such as corrective action, mortification and stakeholder engagement to rebuild its reputation. The temporal analysis suggests that Rio Tinto was “left behind” as a result of its initial response, limiting the effectiveness of its subsequent RRM strategies.Research limitations/implicationsThe findings of this study contribute to an improved understanding of communication strategies for managing a reputation crisis. The extended RRM framework developed in this study provides a comprehensive list of various disclosure strategies that can be used in future studies that analyse disclosure post an environmental or social incident.Practical implicationsThe findings of the study provide insights into the effectiveness of different communication strategies when communicating to stakeholders with varied interests. This study highlights that the timing of the response is critical to restoring lost reputation and a slow response which emphasises financial stakeholders at the expense of the affected communities can be detrimental to RRM, no matter how well-intentioned subsequent strategies are.Social implicationsThis research focuses on a marginal stakeholder group, Indigenous people and communities. The findings offer insights to society into whether corporate strategies to manage a reputation crisis promote and support equity and inclusivity.Originality/valueThis study focuses on a community-based stakeholder, Indigenous groups, a context that has unique cultural intricacies and requires a transition beyond a corporate perspective on RRM.
Measuring organic food consumption experience: scale development and validation
Authors: Liang Austin Rong-Da , Wang Tung-Sheng , Yeh Yu-Chen , Hsiao Teng-Yuan 
Published: December 2024

PurposeThe purpose of this study is to develop organic food consumption experience (OFCE) scales based on structural/functional theory.Design/methodology/approachIn the first step, the construct and item generation of OFCE were developed by a literature review, and 58 items were created for the item pool. In the second step, qualitative interviews were used to evaluate and maintain 35 items. In the third step, an online survey collected 543 valid samples to test reliability and validity with exploratory factor analysis in phase 3A. The AHP method was also used to confirm the construct and items in phase 3B. In the final step, 1,017 valid samples were collected by face-to-face survey to test the formal scale with confirmatory factor analysis.FindingsThis study defines OFCE as the internal and subjective responses that result from a series of interactions between consumers, the shopping environment and organic food. Meanwhile, six dimensions are named: organic food quality, store interactions, organic certification, convenience concerns, health benefits, caring for family and sense of responsibility. In addition, there are significant differences between organic food businesses and consumers regarding their perceptions of OFCE.Originality/valueTo the best of the authors’ knowledge, this is among the first studies to develop OFCE scales. In addition, the results of the study can potentially help organic food marketers develop new promotion strategies.
Unveiling structural and emotional drivers of dynamic capabilities in family firms: the contingent role of firm size
Authors: Forés Beatriz , Fernández-Yáñez José María , Camisón-Zornoza César , Kallmuenzer Andreas , Valeri Marco 
Published: December 2024

PurposeThis study investigates the influence of family involvement in firm ownership on the deployment of dynamic capabilities, differentiating between the more structural aspects of family ownership (i.e. ownership dispersion) and the more emotional aspects (i.e. wealth concentration).Design/methodology/approachWe test our hypotheses on a large base of Spanish family-owned tourism firms. The idiosyncratic characteristics of this economic sector, mainly composed of family-owned firms, make it an excellent context for the purposes of this research.FindingsBuilding on this contextual approach, our study finds that both sides of family ownership have ambivalent effects on the development of dynamic capabilities considering the size of family business.Originality/valueCompetitive pressures force companies to capitalize on dynamic capabilities, as they empower firms to increase their distinctiveness through new products, processes and business management models. However, research remains particularly ambiguous regarding the commitment to innovation and learning capabilities for family businesses, where different aspects of family ownership might alter innovation processes.
Exploring the effect of ODA on poverty: insights from least developed countries
Authors: Narayan Diviya , Singh Baljeet 
Published: December 2024

PurposeThe purpose of this study is to examine the long run impact of official development assistance (ODA) on Poverty levels in a sample of 33 least developed countries (LDCs) from 1991 to 2018.Design/methodology/approachThis study employed second-generation panel econometric techniques like Westerlund (2007), Pedroni (2004) cointegration tests and the augmented mean group (Eberhardt and Bond, 2009); (Eberhardt and Teal, 2010) and fully modified ordinary least squares (Phillips and Hansen, 1990) estimations to ascertain the long-run nexus between the variables of interest.FindingsOur findings revealed that ODA has a significant and positive impact on poverty expansion in LDCs. This indicates that ODA perpetuates poverty in LDCs in the long run. While gross domestic product (GDP) per capita and trade openness significantly contributed to reducing poverty levels. Our findings have several policy implications.Originality/valueThis paper sheds light on a panel of LDCs on which research on the ODA–poverty nexus is sparse in prevailing literature. Although studies have documented the impact of single country episodes on LDCs, research on the panel of LDCs remains largely unexplored. This is surprising given the heightened economic and social issues faced by these cross-sections. Additionally, a sustained downturn in ODA flows to LDCs and the commitment to meet SDG Goal 1 underscore the need for comprehensive analysis on LDCs. Hence, our study aims to address the critical gap in the prevailing literature and contribute to the field.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-05-2024-0390
From abstraction to objectivity: the process of converting organizational values to media artifacts
Authors: Hajkazemi Mahboobeh , Abooyee Ardakan Mohammad , Mohammadesmaeili Neda , Kianie Mojtaba 
Published: December 2024

PurposeThis study addresses a gap in organizational culture literature by detailing the creation of cultural artifacts, specifically media artifacts, that align with values and strategies in a dynamic environment, thereby enhancing organizational change management.Design/methodology/approachParticipatory observations and semi-structured interviews were conducted with nine design professionals from six companies and eleven media artifact audiences from a telecommunication company. Data were analyzed using Braun and Clarke’s thematic analysis.FindingsTwo main findings emerged: “Significant Factors in Designing Media Artifacts,” which encompasses seven themes, and “The Process of Designing Media Artifacts,” which comprises seven process steps.Originality/valueThe study clarifies the term “media artifacts” by identifying two key categories: “Significant Factors in Designing Media Artifacts,” focusing on elements aiding designers and “The Process of Designing Media Artifacts,” outlining the necessary steps and interpretations for creating these artifacts.
Employee experiences, internal employer branding and personal initiative: the mediation effects of employee fun and growth
Authors: Chen Shuyuan , Ahlstrom David 
Published: December 2024

PurposeThis study examined the cross-level effect of internal employer branding on the employees’ personal initiative through their experiences of both growth and fun as the mediators guided in self-determination theory.Design/methodology/approachThis study developed a multi-level design and used multi-source data. Data were collected from 619 employees and 73 managers from 73 firms in Taiwan, which yielded 73 employees–organization dyads. Internal employer branding was treated as an organization-level variable and was rated by a human resources/senior manager from each firm. Employee fun, growth and personal initiative were all treated as individual variables and were rated by five to ten employees from each firm.FindingsThis study provides evidence to support both the direct and indirect positive effects of internal employer branding on existing employees’ personal initiatives through growth and fun.Practical implicationsThe findings provide practical implications for the internal employer branding and employee experience management.Originality/valueThis study addresses the effects of internal employer branding on employees’ experiences and identifies the key psychological state of growth and fun as crucial motivational mechanisms between internal employer branding and personal initiative.
Christianity and entrepreneurship
Authors: Collier Mathew James , Sarpong David 
Published: December 2024

PurposeWe explore the intersection of Catholic social teaching (CST) and entrepreneurship studies which has seemingly evaded scholars’ attention.Design/methodology/approachWe integrate and expand upon prior work to explicate an integrative framework for examining CST and entrepreneurship studies.FindingsWe articulate the mechanisms through which CST and entrepreneurship studies may extend our understanding of the economic paradigm of entrepreneurship studies.Originality/valueWe explicate the economic paradigm of entrepreneurship studies and present the key reasons for Catholicism’s and CST’s exclusion to demonstrate why this is unjustified. Beyond expounding what we mean by CST, we extend the economic paradigm by an application to show why the economic paradigm is flawed and call for more CST-focussed entrepreneurship studies.
The ethnographic crime scene: Tracing the violence within market relations on the Thai‐Myanmar border
Authors: Campbell Stephen 
Published: December 2024

AbstractIn a world of proliferating displacement crises and restricted mobility pathways, low‐wage labor migration has become, for many, a more feasible refuge than formal asylum. The refugee‐as‐displaced‐migrant has thus become emblematic of our time. But how do contemporary displacement crises, and violent ones at that, shape the predicament of the migrant‐refugee in countries of arrival? And how might the particularities of the displaced migrant's vulnerable condition be read as clues, both to violence committed abroad and to the profitable leveraging of said violence in countries of arrival? In this article, I engage these questions through an investigation into how displacement‐inducing violence lingers, as traces, in the lives of Myanmar migrant‐refugees in Thailand. Unfreedom, I find, is internal to ostensibly free market relations. Advancing this claim, I turn to a growing anthropology of borders to grasp the nation's geopolitical perimeter as a social relation that border crossers cannot easily discard—a relation that conditions social life, even at sites far from a given country's territorial margins. I show, in sum, how employers and other regulatory actors in countries of arrival internalize, across borders, displacement‐inducing violence perpetrated elsewhere.
Prevalence of HPV infection in the general population of young and adult males in Italy
Authors: Grande Giuseppe , Graziani Andrea , De Toni Luca , Finocchi Federica , Presciutti Adriano , Corrò Sara , Ferlin Alberto , Garolla Andrea 
Published: December 2024

AbstractBackgroundThe most prevalent sexually transmitted disease in the world has the human papillomavirus (HPV) as its etiological agent.ObjectivesTo evaluate the prevalence of previous and actual HPV infection and the clinical manifestations in unselected males.Materials and MethodsA total of 718 males participating to a surveillance program were asked to complete a study visit at our unit, including semen collection, balanopreputial sulcus swab, and blood collection for total anti‐HPV immunoglobulin G (IgG). When HPV‐DNA was detected, we performed HPV fluorescence in situ hybridization, oral and anal swab, and penoscopy. Because previous studies demonstrated a very high risk for HPV infection in subjects with history of HPV‐induced lesions, with a partner with diagnosed HPV infection or reporting couple infertility or sexual promiscuity and an increase of the risk in males having sex with males, in subjects with unprotected sexual intercourses or in heavy smokers, patients were therefore stratified according to the presence of these known risk factors (RFs).ResultsActual HPV infection was detected in 401/718 subjects (55.85%). Oral HPV‐DNA was reported in 80 subjects and anal HPV infection in 52 subjects. Anti‐HPV IgG antibodies have been detected in 288 subjects. The overall prevalence of HPV exposition, considering actual and/or previous infection was 77.99%. Among infected men, high‐risk HPV genotypes were detected in 66.08%.A total of 514 subjects were considered as the RF population, while 150 were classified in the non‐RF population. There was a significantly higher prevalence of condylomatosis (odds ratio [OR] 4.07) and of seminal infection (OR 6.22) in the RF group.Discussion and ConclusionThese data represent an alert for the healthcare system to perform informative and screening campaigns for HPV infection in males and to promote HPV vaccination both in young people and for adult males with RF for HPV infections.
Early HBcrAg and Anti‐HBc Levels Identify Patients at High Risk for Severe Flares After Nucleos(t)ide Analogue Cessation—A Pooled Analysis of Two Clinical Trials
Authors: Dongelmans Edo J. , Feld Jordan J. , Boonstra André , Brakenhoff Sylvia M. , Wong David , Yim Colina , Claassen Mark , Honkoop Pieter , Hansen Bettina E. , de Man Robert A. , Fung Scott , Berg Thomas , van Bömmel Florian , Janssen Harry L. A. , Sonneveld Milan J. 
Published: December 2024

ABSTRACTBackgroundSevere flares (ALT ≥ 10×ULN) are a well‐recognised adverse outcome after nucleos(t)ide analogue (NA) cessation and may lead to liver failure. Thus, identification of patients at risk for these flares is of major importance.MethodsData were used from two prospective studies on NA cessation conducted in the Netherlands and Canada. Patients were eligible based on EASL criteria. HBcrAg and anti‐HBc levels were measured at end of treatment (EOT) and week 6 (FUW6). Logistic regression was used to study the association with severe flares.ResultsSeventy‐eight patients were analysed with a mean age of 49 years, 16 (21%) Caucasian and a majority (65%) were treated with Tenofovir. Overall, 22 patients (28%) developed a severe flare, and 29 (37%) patients were retreated. At EOT, higher HBcrAg levels (aOR: 1.97, p = 0.05; ≥ 4log: 47% severe flare vs. < 3log: 19%, p = 0.036), lower anti‐HBc (aOR: 0.29, p = 0.036; < 2log: 50% vs. ≥ 3log: 11%, p = 0.029) and higher HBcrAg/anti‐HBc‐ratio (aOR: 3.17, p = 0.015; ≥ 2: 58% vs. < 1.5: 14%, p < 0.001) were associated with an increased risk of severe flares, adjusted for HBsAg. At FUW6, higher HBcrAg (aOR: 2.91, p = 0.035; ≥ 5log: 83%, < 3log: 4%, p < 0.001), lower anti‐HBc (aOR: 0.46, p = 0.29; < 2log: 50% vs. ≥ 3log: 0%, p = 0.003) and higher HBcrAg/anti‐HBc‐ratio (aOR: 2.19, p = 0.048; ≥ 1.75: 52% vs. < 1.75: 8%, p < 0.001) were associated with an increased risk of severe flares, adjusted for HBV DNA and ALT.ConclusionHigher HBcrAg, lower anti‐HBc and higher HBcrAg/anti‐HBc ratio at EOT and during the first weeks of post‐treatment follow‐up are associated with an increased risk of hepatic flares after NA withdrawal and could therefore potentially be used to select patients eligible for therapy cessation and to identify patients requiring retreatment.Trial Registration: This study was a post hoc and follow‐up study of two previously registered clinical trials (NCT01911156 & NTR7001). No new patients were prospectively included