bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatic Safety of Febuxostat Compared with Allopurinol in Gout Patients with Fatty Liver Disease
Authors: Lee Jung Sun , Won Jebum , Kwon Oh Chan , Lee Seung Soo , Oh Ji Seon , Kim Yong-Gil , Lee Chang-Keun , Yoo Bin , Hong Seokchan 
Published: November 2018

Objective.Febuxostat has superior renal safety to allopurinol, but data on its hepatic safety are limited. Thus we compared the hepatotoxicity of febuxostat and allopurinol, and the clinical factors associated with hepatotoxicity, in patients with gout and fatty liver disease (FLD).Methods.We included gout patients treated with allopurinol or febuxostat who were diagnosed with fatty liver based on ultrasonography or computed tomography. Hepatotoxicity was defined as follows: (1) elevation of aspartate aminotransferase (AST)/alanine aminotransferase (ALT) at least 3× the upper limit of normal, when the baseline AST/ALT was normal; or (2) doubling of the baseline AST/ALT, when the baseline AST/ALT was elevated. The factors associated with hepatotoxicity were evaluated by Cox regression analysis.Results.Of 134 patients identified with gout and FLD, 32 (23.9%) received febuxostat and 102 (76.1%) received allopurinol. There were no significant differences in age, body mass index, comorbidity, or disease severity between the groups; however, the incidence of hepatotoxicity was significantly lower in the febuxostat group (3/32, 9.4%) than in the allopurinol group (36/102, 35.3%, p = 0.005). Diabetes (HR 3.549, 95% CI 1.374–9.165, p = 0.009) and colchicine use (HR 11.518, 95% CI 5.515–24.054, p < 0.001) were associated with a higher risk of hepatotoxicity, whereas febuxostat use was associated with a lower risk of hepatotoxicity (HR 0.282, 95% CI 0.086–0.926, p = 0.037).Conclusion.In the 32 patients studied, febuxostat was well tolerated in patients with gout and FLD. However, the presence of diabetes and colchicine use may increase the risk of hepatotoxicity.
Esthétiser la démocratie
Authors: Fourmentraux Jean-Paul 
Published: November 2018

Depuis une vingtaine d’années, l’action Nouveaux commanditaires stimule la création d’œuvres d’art avec la complicité des contextes sociaux et des espaces publics qui les accueillent. L’enjeu est de permettre à des citoyens de passer commande à des artistes contemporains, en vue de la réalisation concertée d’une œuvre d’art susceptible d’acquérir une « valeur d’usage », en résonnance avec la société civile et les projets d’intérêt général. À ce titre, l’action Nouveaux commanditaires offre un cas particulièrement éclairant pour la compréhension des valeurs croisées de l’innovation démocratique et de la création artistique contemporaine. L’œuvre d’art, en tant qu’elle donne forme à une “expérience sensible” au sens de la philosophie pragmatiste d’un John Dewey ou d’un Walter Lippman, est ici envisagée comme une des conséquences de la mise en œuvre du commun, comme l’enjeu d’une instauration autant esthétique que politique.
Primes Dividing Invariants of CM Picard Curves
Authors: Kılıçer Pınar , Lorenzo García Elisa , Streng Marco 
Published: November 2018

AbstractWe give a bound on the primes dividing the denominators of invariants of Picard curves of genus 3 with complex multiplication. Unlike earlier bounds in genus 2 and 3, our bound is based, not on bad reduction of curves, but on a very explicit type of good reduction. This approach simultaneously yields a simplification of the proof and much sharper bounds. In fact, unlike all previous bounds for genus 3, our bound is sharp enough for use in explicit constructions of Picard curves.
Editorial Sección Temática Estudios Organizacionales en Latinoamérica: Oportunidades, perspectivas y proyecciones
Authors: Psicoperspectivas Revista 
Published: November 2018

Esta edición reúne en un número específico, los trabajos que actualmente se realizan en nuestro continente alrededor de los estudios organizacionales. Vistos sus orígenes foráneos lo que da especial carácter a esta convocatoria dice relación con la inquietud por identificar qué es lo que distingue a estos estudios en nuestro continente, preguntándonos por un campo que se debate entre la afirmación, la oposición o incluso la permanente indefinición. Haciendo énfasis en nuestro derrotero local y siguiendo a Ríos, Toro, Pérez, Mandiola y Espejo, se busca destacar y sumar los esfuerzos de organizaciones especializadas que se han consolidado en nuestro continente. Esta Sección Temática está integrada por 13 artículos seleccionados de un total de 30 artículos recibidos. Las contribuciones provienen de diversos ámbitos tanto disciplinarios como geográficos y buscan complejizar las miradas y metodologías para abordar investigaciones sobre los estudios organizacionales en Latinoamérica. Con ellos constatamos que nuestros Estudios Organizacionales se construyen desde el ejercicio de una praxis profesional, junto al ejercicio de hacer ciencia.
An important mechanism of regional O3 transport for summer smog over the Yangtze River Delta in eastern China
Authors: Hu Jun , Li Yichen , Zhao Tianliang , Liu Jane , Hu Xiao-Ming , Liu Duanyang , Jiang Yongcheng , Xu Jianming , Chang Luyu 
Published: November 2018

Abstract. Severe ozone (O3) pollution episodes plague a few regions in eastern
China at certain times of the year, e.g., the Yangtze River Delta (YRD). However, the formation
mechanisms, including meteorological factors, contributing to these severe pollution events
remain elusive. A severe summer smog stretched over the YRD region from
22 to 25 August 2016. This event displayed hourly surface O3 concentrations that
exceeded 300 µg m−3 on 25 August in Nanjing, an urban area in the western
YRD. The weather pattern during this period was characterized by near-surface
prevailing easterly winds and continuous high air temperatures. The formation
mechanism responsible for this O3 pollution episode over the YRD region, particularly
the extreme values over the western YRD, was investigated using
observation data and by running simulations with the Weather Research and Forecasting
model with Chemistry (WRF-Chem). The results showed that the extremely high
surface O3 concentration in the western YRD area on 25 August was
largely due to regional O3 transport in the nocturnal residual
layer (RL) and the diurnal change in the atmospheric boundary layer.
On 24 August, high O3 levels, with peak values of
220 µg m−3, occurred in the daytime mixing layer over the eastern YRD region. During
nighttime from 24 to 25 August, a shallow stable boundary layer formed near
the surface which decoupled the RL above it from the surface. Ozone in the
decoupled RL remained quite constant, which resulted in an O3-rich
“reservoir” forming in this layer. This reservoir persisted due to the absence of O3 consumption from nitrogen
oxide (NO) titration or dry deposition during nighttime. The prevailing
easterly winds in the lower troposphere governed the regional transport of
this O3-rich air mass in the nocturnal RL from the eastern to the western YRD. As
the regional O3 transport reached the RL over the western YRD, O3
concentrations in the RL accumulated and rose to 200 µg m−3 over the
western Nanjing site during the sunrise hours on 25 August. The development of
the daytime convective boundary layer after sunrise resulted in the
disappearance of the RL, as the vertical mixing in the convective boundary layer
uniformly redistributed O3 from the upper levels via the
entrainment of O3-rich RL air down to the O3-poor air at the ground.
This net downward transport flux reached up to 35 µg m−3 h−1,
and contributed a considerable surface O3 accumulation, resulting in severe daytime
O3 pollution during the summer smog event on 25 August in the western YRD region.
The mechanism of regional O3 transport through the nocturnal RL revealed
in this study has great implications regarding understanding O3 pollution
and air quality change.
Arte y Estética de la Disrupción
Authors: Ríos-Espinosa M. Cristina 
Published: November 2018

Este ensayo analiza el modo de ser del juego como disrupción a través del juego, la fiesta y el ritual y su fuerza como transfiguración de lo real mediante la filosofía hermenéutica de Georg Gadamer y Bolívar Echeverría, y la estética de la cotidianidad de Katya Mandoki quienes estudian estos fenómenos disruptivos como alternativas críticas a la noción de estética entendida como desinterés, belleza, buen gusto y genialidad; y a la del arte al servicio de las exigencias de la modernidad. Las artes no son meras producciones materiales, estáticas y anémicas, sino espíritus vivos a través de los cuales podemos hacer un reconocimiento intersubjetivo y comunitario. En este sentido, esta investigación defiende la tesis de una refuncionalidad del arte como disrupción estética para responder a la pregunta de si existe la posibilidad de una transformación de las estéticas y de las prácticas artísticas contemporáneas en oposición al servilismo de las exigencias de la modernidad, para liberar a nuestra sensibilidad del dominio de las formas de vida productivistas mediante la vía lúdica y festiva, una rebelión en el arte.
2018/23 Labour Court treats the consequences of cancer as a disability (BE)
Authors: Busschaert Gautier 
Published: November 2018

2018/23 Labour Court treats the consequences of cancer as a disability (BE)
The Labour Court of Brussels treats the long-term effects of cancer as a disability in accordance with the case law of the ECJ. This has triggered an obligation on employers to consider making reasonable adjustments before looking at dismissal.
2018/25 Two new cases consider whether fathers’ parental leave should be paid the same as mothers’ maternity leave (UK)
Authors: Gegaden Ludivine 
Published: November 2018

2018/25 Two new cases consider whether fathers’ parental leave should be paid the same as mothers’ maternity leave (UK)
Two differently constituted Employment Appeal Tribunals (‘EATs’) have recently considered whether it is sex discrimination to pay men on parental leave less than women on maternity leave. In Capita, the EAT decided that it was not direct sex discrimination to fail to pay full salary to a father taking shared parental leave, in circumstances where a mother taking maternity leave during the same period would have received full pay. However in Hextall, the EAT has indicated that enhancing maternity pay but not pay for shared parental leave may give rise to an indirect sex discrimination claim by fathers.
Two new remarkable genera and two new species of Gyponini (Hemiptera: Cicadellidae: Iassinae) from Brazil
Authors: Domahovski Alexandre C. , Cavichioli Rodney R. 
Published: November 2018

The Neotropical fauna of Gyponini is very diverse and still poorly known. Many new species have characters that do not fit with the currently recognized genera, which makes it necessary to propose new ones. Herein, we propose two new Brazilian genera of Gyponini: Acuthana gen. nov., based on A. transgressa gen. et sp. nov. from the State of Mato Grosso, Central-West Brazil and Rectapona gen. nov. based on R. nigrifascia gen. et sp. nov. from the states of Paraná and São Paulo, South and Southeast Brazil, respectively. Diagnosis, detailed description and illustrations of male and female are provided for each taxon, as well as comparisons with closely related genera.
Préférences des PME en matière de politiques publiques de responsabilité sociale des entreprises : une comparaison France-Québec1
Authors: Labelle François , Courrent Jean-Marie , Spence Martine 
Published: November 2018

Quelles approches en matière de politiques publiques sont préférées par les PME pour soutenir leurs actions de responsabilité sociale ? Ces préférences diffèrent-elles selon les pays ? Une enquête auprès de 300 PME en France et au Québec montre qu’elles préfèrent les approches accompagnatrices aux approches coercitives. Les PME des deux régions réagissent de façon assez semblable à la majorité des politiques qui leur sont présentées, quoique les PME québécoises semblent mieux accepter les approches coercitives et sont plus sensibles aux incitatifs financiers que les PME françaises. Ces différences sont analysées sous l’angle des particularités culturelles des pays.
Saccades and handedness interact to affect scene memory
Authors: Ellmore Timothy M. , Mackin Bridget , Ng Kenneth 
Published: November 2018

Repetitive saccades benefit memory when executed before retrieval, with greatest effects for episodic memory in consistent-handers. Questions remain including how saccades affect scene memory, an important visual component of episodic memory. The present study tested how repetitive saccades affect working and recognition memory for novel scenes. Handedness direction (left–right) and degree (strong/consistent vs. mixed/inconsistent) was measured by raw and absolute laterality quotients respectively from an 8-question handedness inventory completed by 111 adults. Each then performed either 30 s of repetitive horizontal saccades or fixation before or after tasks of scene working memory and scene recognition. Regression with criterion variables of overall percent correct accuracy and d-prime sensitivity showed that when saccades were made before working memory, there was better overall accuracy as a function of increased direction but not degree of handedness. Subjects who made saccades before working memory also performed worse during subsequent recognition memory, while subjects who fixated or made saccades after the working memory task performed better. Saccades made before recognition resulted in recognition accuracy that was better (Cohen’s d = 0.3729), but not significantly different from fixation before recognition. The results demonstrate saccades and handedness interact to affect scene memory with larger effects on encoding than recognition. Saccades before scene encoding in working memory are detrimental to short- and long-term memory, especially for those who are not consistently right-handed, while saccade execution before scene recognition does not appear to benefit recognition accuracy. The findings are discussed with respect to theories of interhemispheric interaction and control of visuospatial attention.
God Enki in Sumerian Royal Ideology and Mythology. By Peeter Espak
Authors: Gadotti Alhena 
Published: November 2018

The God Enki in Sumerian Royal Ideology and Mythology. By Peeter Espak. Philippika, vol. 87.
Wiesbaden: Harrassowitz Verlag, 2015. Pp. xviii + 235. €52 (paper).
Nondestructive adult age at death estimation: Visualizing cementum annulations in a known age historical human assemblage using synchrotron X‐ray microtomography
Authors: Le Cabec Adeline , Tang Nancy K. , Ruano Rubio Valentin , Hillson Simon 
Published: November 2018

AbstractObjectivesAdult age at death estimation continues to challenge physical anthropologists. One estimation method involves counting tooth cementum annulations (TCA). Non‐destructively accessing TCA is a critical step to approaching fossil teeth of unknown age and to verifying life history profiles of human ancestors. This pilot study aims to (a) non‐destructively image TCA in teeth from a known age archeological human population by propagation phase contrast X‐ray synchrotron μCT (PPC‐SR‐μCT) (b) test the correlation between real and estimated ages, and the accuracy, precision and bias of age estimates.Materials and MethodsWe examine 20 permanent human canines (aged 20–81 years), from a 18th to 19th century known age collection from St. Luke's Church (London, England). We scanned transverse segments of acellular cementum in the apical portion of the middle root third using PPC‐SR‐μCT. We generated virtual transverse sections on which two observers perform two sessions of blind TCA counts. We calculate the estimated ages at death by adding 10 years to the TCA counts.ResultsA moderately strong positive linear relationship exists between real and estimated ages (r= 0.76,p< .001), with an average inaccuracy of 16.1 years and an average bias towards underestimation of 15.7 years. This difference is lower in individuals <50 years (6.8 and 6.5 years, respectively,n= 10) compared with those >50 years (24.9 years,n= 10).DiscussionWe reliably imaged and identified TCA in individuals <50 years from a known‐age archeological sample. Scanning refinement will yield a promising alternative to current destructive methods of TCA analyses and to aid access to life history events in adult fossil hominins.
Reactivity of Highly Lewis‐Acidic Diborane(4) toward C≡N and N=N Bonds: Uncatalyzed Addition and N=N Bond‐Cleavage Reactions
Authors: Katsuma Yuhei , Wu Linlin , Lin Zhenyang , Akiyama Seiji , Yamashita Makoto 
Published: November 2018

AbstractThe diboration of the C≡N bond in organic nitriles, and the N=N bond in azobenzene and pyridazine, by the highly Lewis‐acidic tetra(o‐tolyl)diborane(4) are reported. In the reactions with nitriles, azobenzene, and pyridazine, the addition of diborane(4) to the C≡N and N=N bonds was observed. Conversely, the N=N bond in phthalazine was cleaved by an addition/rearomatization sequence.
Gewölbetragwirkung durchlaufender Eisenbetondecken – Rettung funktionstüchtiger Denkmäler?
Authors: Akkermann Jan , Zowada Tobias 
Published: November 2018

AbstractHistorische Eisenbetondecken weisen oft beeindruckende Schlankheiten auf. Die nachhaltige Nutzung der denkmalgeschützten Bausubstanz in z. T. geänderter Funktion bedarf eines Nachweises der Standsicherheit. Die Bestandskonstruktionen lassen sich nach üblichen, aktuell gültigen Bemessungsverfahren oftmals nicht nachweisen. Dem steht häufig die Feststellung einer bis dato schadensfreien Nutzung gegenüber. Parallel zu Belastungsversuchen erscheint der Ansatz der Gewölbetragwirkung von Platten mit horizontaler Verformungsbehinderung vielversprechend als denkmalgerechte und wirtschaftliche Lösungsmöglichkeit zur Minimierung von Ertüchtigungsmaßnahmen. Anhand materiell und geometrisch nichtlinearer Berechnungen wurden die prinzipiellen Effekte bei schlanken, einachsig gespannten Decken untersucht. Auf Basis der Theorie zur Compressive Membran Action wurde ein vereinfachtes Berechnungsmodell für qualitative Parameterstudien entwickelt. Die Nachweisführung mit dem Modell im Rahmen der gültigen Normung zeigt z. T. signifikante Traglastreserven auf. Die Anwendung des Modells bedarf einer eingehenden Materialerkundung im Bestand.
Spectrofluorimetric investigation with green analytical procedures for estimation of bambuterol and terbutaline: Application to pharmaceutical dosage forms and content uniformity testing
Authors: Abo El Abass Mohamed Samah , El‐Awady Mohamed I. 
Published: November 2018

AbstractBambuterol (BAM) and terbultaline (TER) are well known and effective bronchodilators. In this article highly sensitive, green and cost‐effective spectrofluorimetric methods are designed to determine low concentrations of such drugs. The proposed methods are based on an investigation of the native fluorescence properties of aqueous solutions of BAM at 298 nm after excitation at 263 nm and of TER at 313 nm after excitation at 275 nm. Under optimum conditions, the plots of the relative fluorescence intensity versus concentration were rectilinear over the range 0.1–1.2 μg/mL for BAM and 0.05–0.5 μg/mL for TER with a limit of quantitation of 0.067 μg/mL for BAM and 0.018 μg/mL for TER. The methods are simple and hence suitable for application to the quantification of BAM and TER in syrups and tablets without interference from common excipients. Furthermore, based on United States Pharmacopeia (USP) guidelines, the application was extended to determine the content uniformity of the cited drugs in low dose tablets. The developed methods were fully validated according to the guidelines of the International Conference on Harmonization (ICH).
Visible Light‐Driven, One‐pot Amide Synthesis Catalyzed by the B12 Model Complex under Aerobic Conditions
Authors: Tian Hui , Shimakoshi Hisashi , Ono Toshikazu , Hisaeda Yoshio 
Published: November 2018

AbstractA visible light responsive catalytic system with the B12 complex as the catalyst and [Ir(dtbbpy)(ppy)2]PF6 as the photosensitizer was developed. It provides a convenient and efficient way to synthesize amides. Based on this method, trichlorinated organic compounds were converted into amides in the presence of an amine under aerobic conditions at room temperature in a one‐pot procedure. Various trichlorinated organic compounds and an amine source, such as primary, secondary, and cyclic amines, have been evaluated for this transformation, providing the expected products in moderate to excellent yields. Notably, product formation depended on the reaction atmosphere where the amide was obtained under aerobic conditions while partially dechlorinated products were obtained under anaerobic conditions. As this protocol is free from hazardous reagents, extra additives, noble metals, and dangerous gas, the present method provides a novel and efficient approach for amide synthesis under mild and easily controlled conditions.
Dysregulated Translation in Neurodevelopmental Disorders: An Overview of Autism‐Risk Genes Involved in Translation
Authors: Chen Yan‐Chu , Chang Yu‐Wei , Huang Yi‐Shuian 
Published: November 2018

AbstractRegulated local translation—whereby specific mRNAs are transported and localized in subcellular domains where they are translated in response to regional signals—allows for remote control of gene expression to concentrate proteins in subcellular compartments. Neurons are highly polarized cells with unique features favoring local control for axonal pathfinding and synaptic plasticity, which are key processes involved in constructing functional circuits in the developing brain. Neurodevelopmental disorders are caused by genetic or environmental factors that disturb the nervous system’s development during prenatal and early childhood periods. The growing list of genetic mutations that affect mRNA translation raises the question of whether aberrant translatomes in individuals with neurodevelopmental disorders share common molecular features underlying their stereotypical phenotypes and, vice versa, cause a certain degree of phenotypic heterogeneity. Here, we briefly give an overview of the role of local translation during neuronal development. We take the autism‐risk gene list and discuss the molecules that (perhaps) are involved in mRNA transport and translation. Both exaggerated and suppressed translation caused by mutations in those genes have been identified or suggested. Finally, we discuss some proof‐of‐principle regimens for use in autism mouse models to correct dysregulated translation.
Study of open‐type magnetically shielded room for MRI
Authors: Kamata Kiyotaka , Tamari Yozo , Temma Satoru , Goto Koshi , Yunokuchi Kazutomo 
Published: November 2018

AbstractThe magnetic resonance imaging (MRI) is usually installed in a magnetically shielded room (MSR), in order to reduce the leakage flux density to less than 0.5 mT outside the room. The small space enclosed by the wall causes patients a great deal of stress and discomfort because they are isolated from the operators and from the scenery outside. In order to improve amenity for patients in hospitals, open type of MSRs for MRI, which use canceling coils, combined with square cylinders made by magnetic and conductive material, and magnetic material plates instead of magnetic walls. The magnetic shielding effects of open type of MSR combined with square cylinders model made by magnetic, conductive material, magnetic material plates model, and lattice shape model made of magnetic material for MRI are estimated by 3D magnetic field analysis. In this report, we clarify simple lattice of magnetic plate with gap to improve shielding performance using 3D magnetic field analysis.