bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Extreme Rainfall Over India and China Attributed to Regional Aerosol‐Cloud Interaction During the Late 20th Century Rapid Industrialization
Authors: Lin Lei , Xu Yangyang , Wang Zhili , Diao Chenrui , Dong Wenjie , Xie Shang‐Ping 
Published: July 2018

AbstractBoth mean and extreme rainfall decreased over India and Northern China during 1979–2005 at a rate of 0.2%/decade. The aerosol dampening effects on rainfall has also been suggested as a main driver of mean rainfall shift in India and China. Conflicting views, however, exist on whether aerosols enhance or suppress hazardous extreme heavy rainfall. Using Coupled Model Intercomparison Project phase 5 (CMIP5) multimodel ensemble, here we show that only a subset of models realistically reproduces the late‐20th‐century trend of extreme rainfall for the three major regions in Asia: drying in India and Northern China and wetting in Southern China, all consistent with mean rainfall change. As a common feature, this subset of models includes an explicit treatment of the complex physical processes of aerosol‐cloud interaction (i.e., both cloud‐albedo and cloud‐lifetime effects), while simulation performance deteriorates in models that include only aerosol direct effect or cloud‐albedo effect. The enhanced aerosol pollution during this rapid industrialization era is the leading cause of the spatially heterogeneous extreme rainfall change by dimming surface solar radiation, cooling adjacent ocean water, and weakening moisture transport into the continental region, while GHG warming or natural variability alone cannot explain the observed changes. Our results indicate that the projected intensification of regional extreme rainfall during the early‐to‐mid 21st‐century, in response to the anticipated aerosol reduction, may be underestimated in global climate models without detailed treatment of complex aerosol‐cloud interaction.
The Clustering of Severe Dust Storm Occurrence in China From 1958 to 2007
Authors: Guo Li , Fan Bihang , Zhang Fuqing , Jin Zhao , Lin Henry 
Published: July 2018

AbstractChina is subjected to severe dust storms that deteriorate air quality and cause substantial damages to environment and socioeconomics. Although the annual frequency of severe dust storms in China has been declining since the 1950s, the variability of severe dust storm occurrence in time and space remains inadequately described under the changing climate. Based on the continuous observation at 368 meteorological observation sites across the mainland China over a 50‐year period (1958 to 2007), we found that the temporal clustering of severe dust storm outbreak has intensified after 1985, which exacerbated the irregularity in the monthly distribution of severe dust storms. Moreover, the timing of the clustering has shown a higher interannual variation after 1985. Therefore, the variability of severe dust storm occurrence has increased significantly since the 1980s at the annual and monthly time scales. In addition, the relative probability of experiencing severe dust storms with a large influential range has risen since the 1980s. Spatially, severe dust storm outbreak has receded from spreading across the country in the 1950s to primarily affecting north and northwest China in the 2000s. These findings suggest a relatively higher risk of dust storm disaster in north and northwest China that is associated with the intensified clustering of severe dust storm activity in both time and space. Continuous studies are needed to identify the favorable synoptic system that stimulates the clustering of severe dust storm outbreak. We advocate more efforts to enhance severe dust storm prediction and warning dissemination in north and northwest China.
September 2017's Geoeffective Space Weather and Impacts to Caribbean Radio Communications During Hurricane Response
Authors: Redmon R. J. , Seaton D. B. , Steenburgh R. , He J. , Rodriguez J. V. 
Published: July 2018

AbstractBetween 4 and 10 September 2017, multiple solar eruptions occurred from active region AR12673. NOAA's and NASA's well‐instrumented spacecraft observed the evolution of these geoeffective events from their solar origins, through the interplanetary medium, to their geospace impacts. The 6 September X9.3 flare was the largest to date for the nearly concluded solar cycle 24 and, in fact, the brightest recorded since an X17 flare in September 2005, which occurred during the declining phase of solar cycle 23. Rapid ionization of the sunlit upper atmosphere occurred, disrupting high‐frequency communications in the Caribbean region while emergency managers were scrambling to provide critical recovery services caused by the region's devastating hurricanes. The 10 September west limb eruption resulted in the first solar energetic particle event since 2012 with sufficient flux and energy to yield a ground level enhancement. Spacecraft at L1, including DSCOVR, sampled the associated interplanetary coronal mass ejections minutes before their collision with Earth's magnetosphere. Strong compression and erosion of the dayside magnetosphere occurred, placing geosynchronous satellites in the magnetosheath. Subsequent geomagnetic storms produced magnificent auroral displays and elevated hazards to power systems. Through the lens of NOAA's space weather R‐S‐G storm scales, this event period increased hazards for systems susceptible to elevated “radio blackout” (R3‐strong), “solar radiation storm” (S3‐strong), and “geomagnetic storm” (G4‐severe) conditions. The purpose of this paper is to provide an overview of the September 2017 space weather event, and a summary of its consequences, including forecaster, post‐event analyst, and communication operator perspectives.
Pathogen population structure can explain hospital outbreaks
Authors: Spagnolo Fabrizio , Cristofari Pierre , Tatonetti Nicholas P , Ginzburg Lev R , Dykhuizen Daniel E 
Published: July 2018

Abstract
Hospitalized patients are at risk for increased length of stay, illness, or death due to hospital acquired infections. The majority of hospital transmission models describe dynamics on the level of the host rather than on the level of the pathogens themselves. Accordingly, epidemiologists often cannot complete transmission chains without direct evidence of either host–host contact or a large reservoir population. Here, we propose an ecology-based model to explain the transmission of pathogens in hospitals. The model is based upon metapopulation biology, which describes a group of interacting localized populations and island biogeography, which provides a basis for how pathogens may be moving between locales. Computational simulation trials are used to assess the applicability of the model. Results indicate that pathogens survive for extended periods without the need for large reservoirs by living in localized ephemeral populations while continuously transmitting pathogens to new seed populations. Computational simulations show small populations spending significant portions of time at sizes too small to be detected by most surveillance protocols and that the number and type of these ephemeral populations enable the overall pathogen population to be sustained. By modeling hospital pathogens as a metapopulation, many observations characteristic of hospital acquired infection outbreaks for which there has previously been no sufficient biological explanation, including how and why empirically successful interventions work, can now be accounted for using population dynamic hypotheses. Epidemiological links between temporally isolated outbreaks are explained via pathogen population dynamics and potential outbreak intervention targets are identified.
Spin-induced multiferroicity in the binary perovskite manganite Mn2O3
Authors: Cong Junzhuang , Zhai Kun , Chai Yisheng , Shang Dashan , Khalyavin Dmitry D. , Johnson Roger D. , Kozlenko Denis P. , Kichanov Sergey E. , Abakumov Artem M. , Tsirlin Alexander A. , Dubrovinsky Leonid , Xu Xueli , Sheng Zhigao , Ovsyannikov Sergey V. , Sun Young 
Published: July 2018

AbstractThe ABO3 perovskite oxides exhibit a wide range of interesting physical phenomena remaining in the focus of extensive scientific investigations and various industrial applications. In order to form a perovskite structure, the cations occupying the A and B positions in the lattice, as a rule, should be different. Nevertheless, the unique binary perovskite manganite Mn2O3 containing the same element in both A and B positions can be synthesized under high-pressure high-temperature conditions. Here, we show that this material exhibits magnetically driven ferroelectricity and a pronounced magnetoelectric effect at low temperatures. Neutron powder diffraction revealed two intricate antiferromagnetic structures below 100 K, driven by a strong interplay between spin, charge, and orbital degrees of freedom. The peculiar multiferroicity in the Mn2O3 perovskite is ascribed to a combined effect involving several mechanisms. Our work demonstrates the potential of binary perovskite oxides for creating materials with highly promising electric and magnetic properties.
Optomechanical time-domain reflectometry
Authors: Bashan Gil , Diamandi Hilel Hagai , London Yosef , Preter Eyal , Zadok Avi 
Published: July 2018

AbstractOptical fibres constitute an exceptional sensing platform. However, standard fibres present an inherent sensing challenge: they confine light to an inner core. Consequently, distributed fibre sensors are restricted to the measurement of conditions that prevail within the core. This work presents distributed analysis of media outside unmodified, standard fibre. Measurements are based on stimulated scattering by guided acoustic modes, which allow us to listen where we cannot look. The protocol overcomes a major difficulty: guided acoustic waves induce forward scattering, which cannot be mapped using time-of-flight. The solution relies on mapping the Rayleigh backscatter contributions of two optical tones, which are coupled by the acoustic wave. Analysis is demonstrated over 3 km of fibre with 100 m resolution. Measurements distinguish between air, ethanol and water outside the cladding, and between air and water outside polyimide-coated fibres. The results establish a new sensor configuration: optomechanical time-domain reflectometry, with several potential applications.
Biodiversity across trophic levels drives multifunctionality in highly diverse forests
Authors: Schuldt Andreas , Assmann Thorsten , Brezzi Matteo , Buscot François , Eichenberg David , Gutknecht Jessica , Härdtle Werner , He Jin-Sheng , Klein Alexandra-Maria , Kühn Peter , Liu Xiaojuan , Ma Keping , Niklaus Pascal A. , Pietsch Katherina A. , Purahong Witoon , Scherer-Lorenzen Michael , Schmid Bernhard , Scholten Thomas , Staab Michael , Tang Zhiyao , Trogisch Stefan , von Oheimb Goddert , Wirth Christian , Wubet Tesfaye , Zhu Chao-Dong , Bruelheide Helge 
Published: July 2018

AbstractHuman-induced biodiversity change impairs ecosystem functions crucial to human well-being. However, the consequences of this change for ecosystem multifunctionality are poorly understood beyond effects of plant species loss, particularly in regions with high biodiversity across trophic levels. Here we adopt a multitrophic perspective to analyze how biodiversity affects multifunctionality in biodiverse subtropical forests. We consider 22 independent measurements of nine ecosystem functions central to energy and nutrient flow across trophic levels. We find that individual functions and multifunctionality are more strongly affected by the diversity of heterotrophs promoting decomposition and nutrient cycling, and by plant functional-trait diversity and composition, than by tree species richness. Moreover, cascading effects of higher trophic-level diversity on functions originating from lower trophic-level processes highlight that multitrophic biodiversity is key to understanding drivers of multifunctionality. A broader perspective on biodiversity-multifunctionality relationships is crucial for sustainable ecosystem management in light of non-random species loss and intensified biotic disturbances under future environmental change.
Facile transformation of imine covalent organic frameworks into ultrastable crystalline porous aromatic frameworks
Authors: Li Xinle , Zhang Changlin , Cai Songliang , Lei Xiaohe , Altoe Virginia , Hong Fang , Urban Jeffrey J. , Ciston Jim , Chan Emory M. , Liu Yi 
Published: July 2018

AbstractThe growing interest in two-dimensional imine-based covalent organic frameworks (COFs) is inspired by their crystalline porous structures and the potential for extensive π-electron delocalization. The intrinsic reversibility and strong polarization of imine linkages, however, leads to insufficient chemical stability and optoelectronic properties. Developing COFs with improved robustness and π-delocalization is highly desirable but remains an unsettled challenge. Here we report a facile strategy that transforms imine-linked COFs into ultrastable porous aromatic frameworks by kinetically fixing the reversible imine linkage via an aza-Diels-Alder cycloaddition reaction. The as-formed, quinoline-linked COFs not only retain crystallinity and porosity, but also display dramatically enhanced chemical stability over their imine-based COF precursors, rendering them among the most robust COFs up-to-date that can withstand strong acidic, basic and redox environment. Owing to the chemical diversity of the cycloaddition reaction and structural tunability of COFs, the pores of COFs can be readily engineered to realize pre-designed surface functionality.
Dynamical coupling between a nuclear spin ensemble and electromechanical phonons
Authors: Okazaki Yuma , Mahboob Imran , Onomitsu Koji , Sasaki Satoshi , Nakamura Shuji , Kaneko Nobu-Hisa , Yamaguchi Hiroshi 
Published: July 2018

AbstractDynamical coupling with high-quality factor resonators is essential in a wide variety of hybrid quantum systems such as circuit quantum electrodynamics and opto/electromechanical systems. Nuclear spins in solids have a long relaxation time and thus have the potential to be implemented into quantum memories and sensors. However, state manipulation of nuclear spins requires high-magnetic fields, which is incompatible with state-of-the-art quantum hybrid systems based on superconducting microwave resonators. Here we investigate an electromechanical resonator whose electrically tunable phonon state imparts a dynamically oscillating strain field to the nuclear spin ensemble located within it. As a consequence of the dynamical strain, we observe both nuclear magnetic resonance (NMR) frequency shifts and NMR sidebands generated by the electromechanical phonons. This prototype system potentially opens up quantum state engineering for nuclear spins, such as coherent coupling between sound and nuclei, and mechanical cooling of solid-state nuclei.
Multi-time quantum correlations with no spatial analog
Authors: Ringbauer Martin , Costa Fabio , Goggin Michael E. , White Andrew G. , Fedrizzi Alessandro 
Published: July 2018

AbstractMultipartite quantum correlations are a powerful resource that underpins applications from quantum metrology to quantum computing. While most research has focused on spatial correlations, it is now becoming clear that a sequence of measurements on a single quantum system at different points in time reveals a similarly rich, yet fundamentally different structure of multipartite temporal correlations. Here we experimentally observe genuine multi-time correlations in a sequence of three generalized measurements on a single photon. These correlations, manifest by a simultaneous violation of all pairwise Bell inequalities, cannot be reproduced by any spatial quantum state of equal dimension. Our work lays the foundation for the exploration of temporal correlations arising in quantum networks for quantum information applications.
The association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMI
Authors: Kjøllesdal Marte K. R. , Smith George Davey , Ariansen Inger , Kinge Jonas Minet , Degerud Eirik , Næss Øyvind 
Published: July 2018

AbstractThe article aims to describe the association between midlife body mass index (BMI) and cardiovascular disease (CVD)- and all-cause mortality, and to use early adulthood BMI as an instrumental variable for midlife BMI, in order to obtain an estimate less distorted by midlife confounders and reverse causality. Data from Norwegian health surveys (1974–2003) (midlife BMI, smoking, blood pressure, total cholesterol, heart rate), Military Conscription Records, National Tuberculosis Screenings (early adulthood BMI), National Educational Registry and Cause of Death Registry were linked. Participants with data on BMI in early adulthood and midlife were included (n = 148.886). Hazard Ratio (HR) for CVD mortality was higher in men with midlife obesity relative to normal weight (HR = 1.46(95% CI 1.25, 1.70). For all-cause mortality, HR was higher in those with obesity or underweight in midlife relative to normal weight (Men:HR = 1.19(95% CI 1.09, 1.29), HR = 2.49(95% CI 1.81, 3.43) Women:HR = 1.33(95% CI 1.13, 1.56), HR = 1.61(95% CI 1.22, 2.13)). In instrumental variable analyses, increased BMI became more strongly associated with CVD and all-cause mortality, and the increased risk of all-cause mortality among the underweight attenuated.
Biochemical and structural characterization of a mannose binding jacalin-related lectin with two-sugar binding sites from pineapple (Ananas comosus) stem
Authors: Azarkan Mohamed , Feller Georges , Vandenameele Julie , Herman Raphaël , El Mahyaoui Rachida , Sauvage Eric , Vanden Broeck Arnaud , Matagne André , Charlier Paulette , Kerff Frédéric 
Published: July 2018

AbstractA mannose binding jacalin-related lectin from Ananas comosus stem (AcmJRL) was purified and biochemically characterized. This lectin is homogeneous according to native, SDS-PAGE and N-terminal sequencing and the theoretical molecular mass was confirmed by ESI-Q-TOF-MS. AcmJRL was found homodimeric in solution by size-exclusion chromatography. Rat erythrocytes are agglutinated by AcmJRL while no agglutination activity is detected against rabbit and sheep erythrocytes. Hemagglutination activity was found more strongly inhibited by mannooligomannosides than by D-mannose. The carbohydrate-binding specificity of AcmJRL was determined in some detail by isothermal titration calorimetry. All sugars tested were found to bind with low affinity to AcmJRL, with Ka values in the mM range. In agreement with hemagglutination assays, the affinity increased from D-mannose to di-, tri- and penta-mannooligosaccharides. Moreover, the X-ray crystal structure of AcmJRL was obtained in an apo form as well as in complex with D-mannose and methyl-α-D-mannopyranoside, revealing two carbohydrate-binding sites per monomer similar to the banana lectin BanLec. The absence of a wall separating the two binding sites, the conformation of β7β8 loop and the hemagglutinating activity are reminiscent of the BanLec His84Thr mutant, which presents a strong anti-HIV activity in absence of mitogenic activity.
Randomized effectiveness Trial of the Family Check-Up versus Internet-delivered Parent Training (iComet) for Families of Children with Conduct Problems
Authors: Ghaderi Ata , Kadesjö Christina , Björnsdotter Annika , Enebrink Pia 
Published: July 2018

AbstractWe investigated the effectiveness of the Family Check-Up (FCU) and an Internet-based parent-training program (iComet), along with moderators and mediators of outcome. Families (N = 231) with a child with conduct problems were randomized to one of the conditions for 10 weeks of treatment. The drop-out rate was significantly higher in the iComet (39%) compared to FCU (23%). At post-treatment, both conditions resulted in significant improvement, based on parent-report, but no significant interaction between time and condition, with the exception of conduct problem subscale of the Strengths and Difficulties Questionnaire, slightly favoring the FCU. Neither child, nor teacher reports indicated any significant changes on any of the investigated variables. At 1-, and 2-years follow-up, the gains from the treatment were maintained in both conditions, with basically no significant time X condition interactions. A significantly larger proportion of children in the FCU recovered at post-treatment with regard to opposition defiant behavior, inattention, and conduct problems, compared to the iComet, but almost none of these differences remained significant at 1-, and 2-years follow-up. None of the moderators (child age, parental income or education, or pre-treatment level of motivation) or mediators (limit setting, and appropriate or harsh parenting) of outcome turned out to be significant.
Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis
Authors: Ong Catherine W. M. , Fox Katharine , Ettorre Anna , Elkington Paul T. , Friedland Jon S. 
Published: July 2018

AbstractThe importance of neutrophils in the pathology of tuberculosis (TB) has been recently established. We demonstrated that TB lesions in man are hypoxic, but how neutrophils in hypoxia influence lung tissue damage is unknown. We investigated the effect of hypoxia on neutrophil-derived enzymes and tissue destruction in TB. Human neutrophils were stimulated with M. tuberculosis (M.tb) or conditioned media from M.tb-infected monocytes (CoMTB). Neutrophil matrix metalloproteinase-8/-9 and elastase secretion were analysed by luminex array and gelatin zymography, gene expression by qPCR and cell viability by flow cytometry. Matrix destruction was investigated by confocal microscopy and functional assays and neutrophil extracellular traps (NETs) by fluorescence assay. In hypoxia, neutrophil MMP-8 secretion and gene expression were up-regulated by CoMTB. MMP-9 activity and neutrophil elastase (NE) secretion were also increased in hypoxia. Hypoxia inhibited NET formation and both neutrophil apoptosis and necrosis after direct stimulation by M.tb. Hypoxia increased TB-dependent neutrophil-mediated matrix destruction of Type I collagen, gelatin and elastin, the main structural proteins of the human lung. Dimethyloxalylglycin (DMOG), which stabilizes hypoxia-inducible factor-1α, increased neutrophil MMP-8 and -9 secretion. Hypoxia in our cellular model of TB up-regulated pathways that increase neutrophil secretion of MMPs that are implicated in matrix destruction.
A Novel Compound, “FA-1” Isolated from Prunus mume, Protects Human Bronchial Epithelial Cells and Keratinocytes from Cigarette Smoke Extract-Induced Damage
Authors: Jang Andrew J. , Lee Ji-Hyeok , Yotsu-Yamashita Mari , Park Joodong , Kye Steve , Benza Raymond L. , Passineau Michael J. , Jeon You-Jin , Nyunoya Toru 
Published: July 2018

AbstractExtract of the Japanese apricot (JAE) has biological properties as an antioxidant and anti-inflammatory agent. We hypothesized that JAE might exert therapeutic effects on cigarette smoke (CS)-induced DNA damage and cytotoxicity. In this study, we found that concentrated JAE protects against cigarette smoke extract (CSE)-induced cytotoxicity and DNA damage accompanied by increased levels of aldehyde dehydrogenase (ALDH)2, 3A1, and Werner’s syndrome protein (WRN) in immortalized human bronchial epithelial cells (HBEC2) and normal human epidermal keratinocytes (NHEK). Using the centrifugal partition chromatography (CPC) method, we identified an undescribed compound, 5-hydroxymethyl-2-furaldehyde bis(5-formylfurfuryl) acetal (which we named FA-1), responsible for the protective effects against CSE. This chemical structure has not been reported from a natural source to date. Protective effects of isolated FA-1 against CSE were observed in both HBEC2 and NHEK cells. The studies described herein suggest that FA-1 isolated from JAE protects against CSE-induced DNA damage and apoptosis by augmenting multiple isozymes of ALDH and DNA repair and reducing oxidative stress.