bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between bullous pemphigoid and psoriasis: Systematic review and meta‐analysis of case‐control studies
Authors: Phan Kevin , Goyal Sourabh , Murrell Dedee F 
Published: August 2018

AbstractSeveral case reports and cohort studies have recently investigated the potential association between bullous pemphigoid (BP) and psoriasis. It has been speculated that chronic inflammation in the dermo‐epidermal junction can trigger exposure to antigens to autoreactive T cells, resulting in autoimmune blistering disease. However, the association described has been inconsistently reported amongst studies. We performed a systematic review and meta‐analysis to investigation this potential association. We identified four case–control studies for inclusion in the present meta‐analysis, with a total of 4035 bullous pemphigoid cases and 19 215 control cases. There was a significantly higher prevalence of psoriasis in BP compared to controls (2.6% vs 1.1%, OR 2.5, 95% CI 1.4–4.6). Subgroup analysis showed that this association remained significant in both males (3.0% vs 1.3%, OR 2.4, 95% CI 1.6–3.6) as well as females (1.9% vs 0.7%, OR 2.9, 95% CI 1.4–5.9). A significantly higher proportion of cases were reported in males (3.0% vs 1.9%, OR 1.75, 95% CI 1.1–2.7). This pooled analysis of existing case–control studies to date demonstrates a significant association between BP and psoriasis. We also showed that in contrast with the majority of autoimmune diseases which are predisposed in females, that the coexistence of BP and psoriasis appears to be predisposed in male patients.
Pulmonary function and bronchial reactivity 4 years after the first virus‐induced wheezing
Authors: Leino Annamari , Lukkarinen Minna , Turunen Riitta , Vuorinen Tytti , Söderlund‐Venermo Maria , Vahlberg Tero , Camargo Carlos A. , Bochkov Yury A. , Gern James E. , Jartti Tuomas 
Published: August 2018

AbstractBackgroundWheezing illnesses among young children are common and are a risk factor for asthma. However, determinants of childhood bronchial reactivity, a key feature of asthma, are largely unknown. The aim of this study was to determine how patient characteristics during the first severe virus‐induced wheezing episode are associated with pulmonary function at preschool age.MethodsStudy consisted of 76 children presenting with their first wheezing episode at the ages of 3 to 23 months. At study entry, viral etiology, rhinovirus genome load, atopic and clinical characteristics, and standardized questionnaire were analyzed. At 4‐year follow‐up visit, impulse oscillometry with exercise challenge was performed.ResultsAt study entry, the mean age of the children was 12 months (SD 6.0), 57 (75%) were rhinovirus positive, and 22 (30%) were sensitized. At follow‐up visit four years later, the mean age of the children was 60 months (SD 7.9) and 37 (49%) were using asthma medication regularly (discontinued before testing in 25 [68%] children). Bronchial reactivity (≥35% change in mean crude values of resistance) after exercise challenge or bronchodilation was present in nine (12%) children. Children with atopic sensitization at the time of the first wheezing episode were more often likely to develop bronchial reactivity (odds ratio 8.8, P = 0.03) than the children without sensitization. No other significant associations were found.ConclusionsAtopic sensitization at the time of the first severe wheezing episode is an important early risk factor for increased bronchial reactivity at preschool age.
Relationship Between Central Venous Catheter Protein Adsorption and Water Infused Surface Protection Mechanisms
Authors: Sutherland David W. , Blanks Zachary D. , Zhang Xin , Charest Joseph L. 
Published: August 2018

AbstractCentral venous catheters (CVCs) are implanted in the majority of dialysis patients despite increased patient risk due to thrombotic occlusion and biofilm formation. Current solutions remain ineffective at preventing these complications and treatment options are limited and often harmful. We present further analysis of the previously proposed water infused surface protection (WISP) technology, an active method to reduce protein adsorption and effectively disrupt adsorbed protein sheaths on the inner surface of CVCs. A WISP CVC is modeled by a hollow fiber membrane (HFM) in a benchtop device which continuously infuses a saline solution across the membrane wall into the blood flow, creating a blood‐free boundary layer at the lumen surface. Total protein adsorption is measured under various experimental conditions to further test WISP performance. The WISP device shows reduced protein adsorption as blood and WISP flow rates increase (P < 0.040) with up to a 96% reduction in adsorption over the no WISP condition. When heparin is added to the WISP flow, protein adsorption (0.097[+0.035/–0.055] µg/mm2) is reduced when compared to both bolus administration and nondoped WISP, 0.406(+0.056/–0.065) µg/mm2 (P = 0.001) and 0.191 (+0.076/–0.126) (P = 0.029), respectively. Additionally, when heparinized WISP is applied to a preadsorbed protein layer, 0.375(+0.114/–0.164) µg/mm2, it displays the ability to reduce the previously‐adsorbed protein, 0.186(+0.058/–0.084) µg/mm2 (P = 0.0012), suggesting aptitude for intermittent treatments. The WISP technology not only shows the ability to reduce protein adsorption, but also the ability to remove preadsorbed material by effectively delivering drugs to the point of adsorption; functionalities that could greatly improve clinical outcomes.
Preterm infant showed better object handling skills in a neonatal intensive care unit during silence than with a recorded female voice
Authors: Lejeune Fleur , Brand Laure‐Anne , Palama Amaya , Parra Johanna , Marcus Leïla , Barisnikov Koviljka , Debillon Thierry , Gentaz Edouard , Berne‐Audéoud Frédérique 
Published: August 2018

AbstractAimThis study compared whether preterm infants showed better tactile abilities during silence or when they heard a prerecorded female voice at different intensities.MethodsWe studied 74 preterm infants of 28–35 weeks’ postconceptional age who were admitted to a French neonatal intensive care unit from 2014 to 2017. They were presented with wooden objects, one smooth and one angled, at various points during silence (n = 26) or while listening to a female voice at +5 (n = 24) or +15 decibels (n = 24) inside their incubator. We compared the conditions to see if there was any difference in how the infants handled the objects and also compared familiar and unfamiliar objects.ResultsThe preterm infants showed better handling skills and only displayed effective discrimination, during silence. We found that 27.1% of the infants exposed to female voices failed to get habituated to the object, compared to 7.7% in the silence condition (p < 0.05) and success during the voice conditions required more trials (6.1 vs. 5.3) than the silence condition (p = 0.05). The different voice intensities made no difference.ConclusionBeing exposed to a female voice had a negative impact on preterm infants’ tactile sensory learning, regardless of its intensity.
Facilitated tucking during early neonatologist‐performed echocardiography in very preterm neonates
Authors: Gautheyrou Laurène , Durand Sabine , Jourdes Emilie , De Jonckheere Julien , Combes Clémentine , Cambonie Gilles 
Published: August 2018

AbstractAimTo assess the effect of facilitated tucking (FT), a nonpharmacologic nursing intervention, on echocardiographic parameters and infant comfort collected prospectively during neonatologist‐performed echocardiography.MethodsEchocardiography was performed twice, in standard conditions and with FT; the order was randomised by computer. Echocardiography provided data on pulmonary artery flow and pressure, right and left ventricular function, and persistent ductus arteriosus. Comfort was assessed by a behavioural scale of pain, variations in heart rate (HR) and SpO2, and a newborn infant parasympathetic evaluation index based on the high‐frequency variability in HR.ResultsFifty newborns, with mean gestational age of 28 [26.6–29.0] weeks and mean birthweight of 950 [780–1190] g, were studied at a postnatal age of 13 [9–27] hours. FT was associated with longer acceleration time/right ventricular ejection time in the main pulmonary artery (p = 0.006), reduced averaged HR variations (p = 0.03) and lower pain scores (p < 0.001). The other haemodynamic parameters and the parasympathetic index were not influenced by FT.ConclusionEchocardiography performed soon after birth in very premature neonates may generate mild discomfort. FT during echocardiography is associated with lower pulmonary artery pressures and improves infant's comfort during this examination.
Structural brain maturation differs between preterm and term piglets, whereas brain activity does not
Authors: Plomgaard A M , Andersen A D , Petersen T H , van de Looij Y , Thymann T , Sangild P T , Thomsen C , Sizonenko S V , Greisen G 
Published: August 2018

AbstractAimThe aim of the study was to investigate whether amplitude‐integrated electroencephalography (aEEG) and cerebral magnetic resonance imaging (MRI) in preterm piglets would provide measures of cerebral functional, microstructural and anatomical maturation, which might reflect the signs of functional brain immaturity, documented in preterm piglets.MethodsDuring July–October 2013 at the NEOMUNE Centre, Copenhagen University, Denmark, 31 preterm (90% gestation) and 10 term piglets underwent aEEG on days 1, 2, 4 and 11, and MRI on day 25. Physical activity levels were recorded.ResultsPreterm showed delayed neonatal arousal and physical activity, relative to term piglets. Preterm piglets had lower growth rates and brain volume than term piglets, but aEEG patterns were similar. MRI mean diffusivity was also similar, but fractional anisotropy (FA) was lower in preterm piglets (p < 0.001).ConclusionFunctional brain maturation, as assessed by aEEG, was relatively advanced in preterm piglets. Conversely, the low FA in the preterm piglets suggests that the white matter microstructure remains less mature in preterm compared to term piglets at postnatal day 25. The results might be utilised to define whether and how preterm piglets may contribute to preclinical models for brain development in preterm infants.
Successful closure of a complicated duodenal ulcer perforation with an expandable esophageal stent
Authors: Stavrou George , Rafailidis Vasileios , Diamantidou Anna , Kouskouras Constantinos , Michalopoulos Antonios , Kotzampassi Katerina 
Published: August 2018

AbstractLaparotomy and reoperation remain the standard procedures for patients with suture line disruption after the initial surgical treatment for duodenal ulcer perforation has failed. Recently, endoscopic stents have been employed for dehiscence of the suture line after a surgical repair or even as a primary treatment. We present such a case, the fourth in the literature. In this case, a partially covered stent was placed to cover the duodenal perforation opening after an unsuccessful stitching 6 days earlier. We discuss the difficulties in stent positioning, the choice of sealant, and possible complications. Overall, for older patients with comorbidities, endoscopic stent placement could be considered a promising alternative minimally invasive treatment.
BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor
Authors: Tsai Hui‐Jen , Jiaang Weir‐Torn , Shih Neng‐Yao , Fletcher Jonathan A. , Lin Ming‐Jon , Yang Ming‐Yu , Chen Chiung‐Tong , Hsu Tsu‐An John , Wu Chun‐Chieh , Lin Hui‐You , Chen Li‐Tzong 
Published: August 2018

Gastrointestinal stromal tumor (GIST) is a type of KIT‐driven cancer. KIT gene mutations are found in approximately 80% of GISTs, and most of these mutations occur in exon 9 and exon 11. Imatinib has been successfully used as a first‐line treatment for advanced GIST, with a significant improvement in progression‐free survival (PFS) and overall survival. However, disease progression might develop due to primary or secondary resistance to imatinib. Sunitinib and regorafenib have been approved as second‐ and third‐line treatments for advanced GIST patients, with median PFS values of 6.8 and 4.8 months, respectively. However, these relatively modest improvements in PFS underscore the need for more effective KIT inhibitors. BPR1J373 is a multitargeted kinase inhibitor that has been shown to inhibit the proliferation of KIT‐driven acute myeloid leukemia cells in vitro and in vivo. In this study, we found that BPR1J373 inhibited proliferation and induced apoptosis by targeting KIT in GIST cells with KIT gene mutations. BPR1J373 also induced cell cycle arrest and senescent change in KIT‐mutant GIST48 cells, probably by targeting aurora kinase A. In the KIT‐null COS‐1 cell‐based system, BPR1J373 effectively inhibited KIT with single or double mutations of KIT developed in GIST. The antiproliferative effect was also consistently evident in GIST430 tumor‐grafted mice. The results suggest that BPR1J373 could be a potential anticancer drug for GIST and deserves further investigation for clinical applications.
Impact of oral health literacy on self‐reported missing data in epidemiological research
Authors: Firmino Ramon Targino , Fraiz Fabian Calixto , Montes Gisele Ristow , Paiva Saul Martins , Granville‐Garcia Ana Flávia , Ferreira Fernanda Morais 
Published: August 2018

AbstractObjectivesTo investigate whether oral health literacy (OHL) impacts missing data obtained through self‐reporting in oral health epidemiological research.MethodsA cross‐sectional study was conducted with parents (n = 344) of 4‐ to 5‐year‐old children randomly selected from public schools within the city of Curitiba, Brazil. Parental OHL was measured using the Brazilian version of the Rapid Estimate of Adult Literacy in Dentistry (BREALD‐30). Parents answered a set of questionnaires comprising 88 items concerning sociodemographic and economic data, children's access to dental services, oral hygiene behaviour, diet and mealtime behaviour. The total number of unanswered items (TUI) and the number of unanswered items in each type of question (open‐ended, dichotomous, multiple choice with up to 4 options and with 5‐9 options) for each participant was compared across different levels of OHL (chi‐squared, Mann‐Whitney, Kruskal‐Wallis and Spearman's correlation test). Multiple Poisson regression was used to estimate rate ratios (RR) of TUI between OHL scores and their respective 95% confidence interval (95% CI).ResultsApproximately one‐third of studied parents (37%) exhibited low OHL (BREALD‐30 ≤ 21). The prevalence of missing data in at least one item was 85.5%. Low OHL was associated with failing to respond open‐ended items (P = 0.003) and multiple‐choice items with up to 4 (P = 0.003) and between 5 and 9 options (P = 0.030). There was a negative correlation between OHL scores and TUI (r = −0.195; P < 0.001), as well as with the number of unanswered items in all types of questions (P < 0.01), except dichotomous questions. Parents with lower OHL were more likely to show higher values of TUI (RR 0.95: 0.93‐0.98), when adjusted by income and education.ConclusionsParticipants with lower OHL were significantly more likely to fail to complete research questionnaires. The impact of OHL on missing data was greater with more complex types of items.
Long‐term stability of autologous bone graft of intraoral origin after lateral sinus floor elevation with simultaneous implant placement
Authors: Maddalone Marcello , Mirabelli Luca , Venino Pier Matteo , Karanxha Lorena , Porcaro Gianluca , Del Fabbro Massimo 
Published: August 2018

AbstractBackgroundLateral approach to maxillary sinus floor elevation (LSFE) with autologous bone grafts and simultaneous implant insertion is a widespread technique for prosthetic rehabilitation of the atrophic maxilla.PurposeTo analyze implant survival and autologous bone graft resorption after LSFE, in patients with at least 5 years follow‐up.Materials and MethodsThirty‐three patients (mean age 56 years, range 46‐68 years) who had undergone LSFE with intraoral autologous bone graft from mandibular ramus and simultaneous implant insertion were included. A minimum of 5 years of follow‐up was required. The total peri‐implant bone height was measured at mesial and distal aspects of the implants immediately after surgery (T0) and after a period ranging from 5 to 11.5 years after surgery (mean 7.65 ± 1.80 years) (T1) on digital panoramic and periapical radiographs. Wilcoxon matched‐pairs signed rank test was used to compare bone graft height at T0 and T1. The influence of patient‐, surgery‐, and implant‐related factors on the outcomes was investigated.ResultsOf the 58 implants placed, no one was lost. All prostheses were in function, and no biological or mechanical complications occurred. The residual ridge height at the involved sites averaged 6.48 ± 1.72 mm. The mean bone height at grafted regions was 12.05 ± 2.47 mm at T0 and 12.13 ± 2.39 mm at T1 (not statistically significant). Marginal bone level change at T1 averaged −1.22 ± 1.60 mm. None of the evaluated factors significantly affected the results.ConclusionAutologous bone grafts from intraoral donor sites display excellent volume stability over time that may contribute to optimal outcomes of the procedure.
Banded vs. non‐banded Roux‐en‐Y gastric bypass for morbid obesity: a systematic review and meta‐analysis
Authors: Magouliotis D. E. , Tasiopoulou V. S. , Svokos K. A. , Svokos A. A. , Sioka E. , Tzovaras G. , Zacharoulis D. 
Published: August 2018

SummaryWe aim to review the available literature on patients with morbid obesity treated with banded (BRYGB) or non‐banded Roux‐en‐Y gastric bypass (NBRYGB), in order to compare the clinical outcomes and intraoperative parameters of the two methods. A systematic literature search was performed in PubMed, Cochrane library and Scopus databases, in accordance with the PRISMA guidelines. Eight studies met the inclusion criteria incorporating 3899 patients. This study reveals similar rates of complications, mortality, remission of type 2 diabetes, hypertension, dyslipidaemia, gastroesophageal reflux and obstructive sleep apnoea, along with similar % excess weight loss (%EWL) at 1 and 2 years postoperatively. In contrast, according to an analysis of two eligible studies the BRYGB procedure was associated with increased %EWL at 5 years postoperatively. These results should be interpreted with caution due to the small number of statistical arms and randomized controlled studies. However, the present article represents the best available evidence in the field. Well‐designed, randomized controlled studies, comparing BRYGB to NBRYGB, are necessary to further assess their clinical outcomes.
Pilot study on a new concept of documenting the clinical relevance of patch test results in contact dermatitis patients
Authors: Uter Wolfgang , Bauer Andrea , Bensefa‐Colas Lynda , Brans Richard , Crépy Marie‐Noëlle , Giménez‐Arnau Ana , Larese Filon Francesca , Ljubojević Hadžavdić Suzana , Pesonen Maria , Schuttelaar Marie L.A. , Wilkinson Mark 
Published: August 2018

BackgroundAssessment of the clinical relevance of patch test reactions is an essential part of the diagnostic work‐up of patients with (occupational) contact dermatitis. However, final diagnostic information, particularly the clinical relevance of allergic patch test reactions, has hitherto been ill‐represented in clinical documentation systems (patch test software) and surveillance registries based on these.ObjectivesTo develop, implement as a pilot study, and analyse concerning feasibility and contents a new concept of representing the full scope of diagnostic information utilized in the diagnosis of patients with (occupational) contact dermatitis.MethodsOn the basis of a European working group discussion on items to document and catalogue lists to use for this purpose, an online documentation system to collect data was set up, followed by pilot use involving 9 dermatology departments across Europe.ResultsData on 176 patients with suspected occupational hand dermatitis were included; among these, work‐relatedness was confirmed in 150, and in 53 non‐occupational aetiology was the sole or a contributory cause. Data were further analysed with regard to occupations, product categories, substances (haptens), source of information on which the evaluation was based, and various combinations of these factors, to illustrate the usefulness of the proposed data representation.ConclusionsAn improved method of data collection is presented that more accurately links allergen to exposure and to clinical disease and patient history, and thus better represents clinical relevance. This enables more precise analysis of the causation of contact dermatitis, occupational or non‐occupational, and thereby better targeting of prevention. The development of future databases should incorporate the above considerations to record the results of investigation.
Upregulated miR‐1258 regulates cell cycle and inhibits cell proliferation by directly targeting E2F8 in CRC
Authors: Zhang Zhiyuan , Li Jie , Huang Yuanjian , Peng Wen , Qian Wenwei , Gu Jiou , Wang Qingyuan , Hu Tao , Ji Dongjian , Ji Bing , Zhang Yue , Wang Shijia , Sun Yueming 
Published: August 2018

AbstractObjectivesMicroRNAs (miRNAs) as small noncoding RNA molecules function by regulating their target genes negatively. MiR‐1258 was widely researched in multicancers, but its role remains unclear in colorectal cancer (CRC).MethodsThe expression of miR‐1258 and its specific target gene were detected in human CRC specimens and cell lines by miRNA RT‐PCR, qRT‐PCR and Western blot. The effects of miR‐1258 on CRC proliferation were evaluated using CCK‐8 assays, EdU incorporation, colony formation assays and cell‐cycle assays; in vitro and the in vivo effects were investigated using a mouse tumorigenicity model. Luciferase reporter and RIP assays were employed to identify interactions between miR‐1258 and its specific target gene.ResultsMiR‐1258 was downregulated in CRC tissues and CRC cell lines, and upregulated miR‐1258 was proved to inhibit proliferation and arrest cell cycle at G0/G1 in vitro and vivo. Luciferase reporter, RIP and western blot assays revealed E2F8 to be a direct target of miR‐1258. The effects of miR‐1258 in proliferation and cell cycle regulation can be abolished by E2F8 through rescue experiments. By directly targeting E2F8, miR‐1258 influenced the expression of several cell‐cycle factors, including cyclin D1 (CCND1) and cyclin dependent kinase inhibitor 1A (p21).ConclusionMiR‐1258 may function as a suppressive factor by negatively controlling E2F8, thus, highlighting the potential role of miR‐1258 as a therapeutic target for human CRC.