bluuebunny/crossref_metadata_2025_split huggingface dataset:
KONSTRUKSI GENDER MELALUI REPRESENTASI ALAM DALAM PUISI POST SCRIPTUM KARYA TOETY HERATY DAN THE SNAKE CHARMER KARYA SAROJINI NAIDU
Authors: Nastiti Nimas Diah Putri Ayu Dewi , Basri Syaiful Qadar 
Published: September 2019

Perempuan dianggap memiliki hubungan spesial dengan alam. Hubungan spesial tersebut dapat dilihat dalam kata “Ibu Pertiwi”. Kata “Pertiwi” memiliki arti “Bumi” dan disandingkan dengan kata “Ibu” sebagai sebuah ungkapan yang menunjukkan perempuan sering dikaitkan dengan alam. Kedekatan tersebut dapat dianggap sebagai sebuah anugerah sekaligus bentuk stereotip. Tulisan ini menganalisis dua puisi <em>Post Scriptum </em>karya Toety Heraty dan <em>The Snake Charmer</em> karya Sarojini Naidu. Melalui dua karya tersebut, penelitian ini melihat cara perempuan direpresentasi melalui simbolisasi alam sehingga dapat menjawab apakah kedekatan perempuan dan alam merupakan konstruksi sosial ataukah bentuk yang sebenarnya. Tulisan ini menemukan bahwa hubungan perempuan dan alam dalam puisi <em>Post Scriptum</em> merupakan hal yang tidak patut untuk dirayakan. Pengaitan alam dan perempuan menunjukkan adanya operasi kuasa niliai-nilai sosial (<em>Cultural Ecofeminism)</em>. Puisi <em>The Snake Charmer</em><em> </em> ditemukan bahwa hubungan alam dan perempuan merupakan hal istimewa yang menunjukkan keagungan dan kesucian perempuan (<em>Essentialism Ecofeminism</em>). Dalam konteks ini, analisis kedua puisi dikaitkan dengan konteks budaya yang melatarbelakangi penulisan karya.
Mining TCGA database for prognostic genes in head and neck squamous cell carcinoma microenvironment
Authors: Ran Qiuchi , Long Shengrong , Ye Yan , Sunchuri Diwas , Liang Hong , Guo Zhuling 
Published: September 2019

Abstract
Background Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors. Many previous reports have already shown that the extent of infiltrating immune and stromal cells in tumor tissues and the tumor microenvironment (TME) cells play a significant role in the overall prognosis. Methods The convenient access to The Cancer Genome Atlas (TCGA) database facilitates global gene expression profiling and database mining in a large‐scale for potential correlation between genes and overall survival of a variety of malignancies including HNSCC. The quantification of the immune and stromal components in tumor tissues could be facilitated by calculating mmune scores and stromal scores on the basis of Estimation of stromal and Immune cells in Malignant Tumor tissues using Expression data (ESTIMATE) algorithm could facilitate the quantification of the immune and stromal components in tumor tissues. The effects of genes involved in immune and stromal cells on prognosis were categorized. Prognosis associated genes of HNSCC patients were further identified. Result This study showed that GIMAP6, SELL, TIFAB, KCNA3, P2RY8 and CCR4 may mediate immune response, extracellular matrix, and immunoglobulin binding via neutrophil activation in HNSCC. Conclusion Depicting a comprehensive landscape of the TME characteristics of HNSCC may therefore help to interpret the responses of HNSCC to immunotherapies and provide new strategies for the treatment of cancers.
Continuous renal replacement therapy without anticoagulation in critically ill patients at high risk of bleeding: a systematic review and meta-analysis
Authors: Zhang Wei , Bai Ming , Yu Yan , Chen Xiaolan , Zhao Lijuan , Chen Xiangmei 
Published: September 2019

Abstract
Abstract Background: Continuous renal replacement therapy (CRRT) has been widely used in the critical care setting and anticoagulation is usually necessitated. However, critically ill patients are commonly at incremental risk of bleeding, which contributed to the hesitation of anticoagulant use for CRRT in clinical practice. The current guideline recommended CRRT proceed without anticoagulation in patients with contraindication to citrate and increased bleeding risk. Nevertheless, the efficacy of anticoagulation-free CRRT remains inconsistent. Therefore, the purpose of our present systematic review is to evaluate the efficacy and safety of anticoagulant-free CRRT based on the current literatures. Methods: We conducted a comprehensive search of PubMed (US National Library of Medicine, Bethesda, MD, USA), Cochrane Library databases and EMBASE from database inception to January 12, 2019 for potential candidate studies. Studies included adult critically ill (age > 18 years) patients with increased bleeding risk, and underwent CRRT without anticoagulation were considered for the inclusion. Results: Finally, 17 observational studies and 3 randomized controlled trials with 1615 patients were included in our present meta-analysis. There was no significant difference in filter lifespan between the anticoagulation-free and systemic heparin group. The filter lifespan was significantly prolonged in the citrate (WMD -23.01, 95%CI [-28.62, -17.39], P < 0.001; I 2 = 0%, P = 0.53) and nafamostat (WMD -8.4, 95%CI [-9.9, -6.9], P < 0.001; I 2 = 33.7%, P = 0.21) groups, compared with anticoagulation-free group. The averaged filter lifespan of the anticoagulation-free CRRT ranged from 10.2 to 52.5 hours. Conclusion: The filter lifespan in anticoagulation-free patients with increased bleeding risk was comparable to that in patients without increased bleeding risk underwent systemic heparin anticoagulation CRRT. Nafamostat was not recommended for CRRT anticoagulation due to its drawbacks. Currently, the optimal choice of anticoagulation strategy for critically ill patients without citrate contraindications at high risk of bleeding should be regional citrate anticoagulation. Further studies should focus on the special cut-off value of activated partial thromboplastin time (APTT), international normalized ratio (INR) and platelet (PLT) count, at which the anticoagulation-free CRRT would be beneficial. Key words: Anticoagulation, critically ill patients, continuous renal replacement therapy, filter failure, bleeding
Polymorphisms of the MTHFR Gene in Mothers of Children with Trisomy 21 (Down Syndrome) in a Polish Population
Authors: Czechowicz Paulina , Malodobra-Mazur Malgorzata , Cukierska Karolina , Lebioda Arleta , Jonkisz Anna , Dobosz Tadeusz , Smigiel Robert 
Published: September 2019

Abstract
Background:
Down Syndrome (DS) is the most frequent cause of intellectual disability. In 95% of cases, it is caused by simple trisomy of chromosome 21 resulting from nondisjunction of chromosomes in meiotic division. Currently, the molecular and cellular mechanisms responsible for the phenomenon of nondisjunction are unknown. In this paper, we evaluated the incidence of five single-nucleotide polymorphisms (SNPs) of the MTHFR gene in a population of Polish mothers who had given birth to children with trisomy 21 in comparison with a control group of women with healthy offspring.
Methods:
The test material comprised venous blood collected from mothers who had given birth to a child with Down syndrome (study group, n = 130) as well as from women who had given birth to children without trisomy 21 (control group, n = 88). DNA was isolated using a kit manufactured by Qiagen. Amplification was carried out using a Qiagen Multiplex PCR Kit (Qiagen); genotyping was performed using SNaPshot Genotyping MasterMix (Applied Biosystems).
Results:
No statistically significant differences were observed in the frequency of genotypes between the examined groups in terms of the polymorphisms of the MTHFR gene. Conclusions: In the studied Polish population, no relationship was found between the occurrence of particular genotypes of the MTHFR gene, i.e. 677CT, 1298AC, rs3737964, rs4846048, and rs1994798, in women and the birth of children with trisomy 21. The results contradict the validity of research on polymorphisms of the MTHFR gene as potential predisposing factors for the occurrence of trisomy 21 in children.
Maternal Testosterone Levels During Pregnancy Are Not associated with Birth Weights of Offspring: A Prospective Cohort Study
Authors: XU GUFENG , Sun Li-Juan , Yang Mei-Ling , Liao Yun , Chen Yuan , Wang Ya-Yun , Li Jun-Qin , Liu Miao-E , Chen Guang-Di , Luo Qiong 
Published: September 2019

Abstract
Background Testosterone is an important sex hormone which participates in many physiological processes. However, there is conflicting evidence on effect of testosterone on fetal development. We aim to investigate the associations between maternal testosterone levels and pregnancy outcomes.Design and Methods We conducted a prospective cohort in a university-affiliated hospital. A total of 1,087 singleton pregnant women were included in the study. They were followed-up until delivery. The primary outcome was birth weight. The second outcomes were the prevalence of preterm birth, low birth weight, small for gestational age, preeclampsia, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, premature rupture of membranes, and low APGAR score (<7).Results We did not observe any significant association between maternal testosterone level and birth weight after adjustment. Prevalence of medical complications was also not associated with maternal testosterone levels.Conclusions Maternal testosterone levels during pregnancy is not associated with birth weights as well as the prevalence of medical complications.
Knowledge, Attitude, Practice and its associated factors on menstrual hygiene among high school students of North Wollo Zone, Ethiopia, 2019: A cross-sectional study
Authors: Gedefaw Getnet , Endalew Fentanesh , Azmeraw Bitewsh , Walelign Bethelhem , Shitie Eyob 
Published: September 2019

Abstract
Introduction Menstruation is the physiologic manifestation of cyclic uterine bleeding due to shedding and proliferation of the endometrium following invisible action and interplay of hormones mainly through the hypothalamus-pituitary-ovarian axis. Lack of proper menstrual hygiene predisposes women to different infectious and chronic obstetric and gynecological problems. Therefore, this study aimed to assess knowledge, attitude, practice and its associated factors of menstrual hygiene among high school students in North Wollo Zone, Woldia, Ethiopia.Methods A Facility based cross-sectional study was implemented from October 1-December 10, 2018. The data was collected using structured, pretested questioners among female high school students. Systematic random sampling technique was implemented. Data was entered and analyzed through Epi data 3.1 and SPSS respectively.Results This study revealed that 365(89.2%), 200(48.9%) and 196(47.9%) of the study participants have good knowledge, good practice and good attitude about menstrual hygiene respectively. Being grade 10 students [AOR=3.96, 95% CI =2.0-7.8], and having good practice of menstrual hygiene (AOR=2.52, 95% CI= 1.26-5) had positive association with menstrual hygiene knowledge. Maternal education level (AOR=1.86, 95% CI=1.18-2.9), being grade 10 students (AOR =2.3, 95% CI=1.48-3.56) were associated factors for practicing menstrual hygiene. Being grade 10 students (AOR=1.9, 95% CI=1.2-2.8), age ≥18 years (AOR=1.67, 95% CI=1.09-2.55) were statistically and positively associated with the attitude of menstrual hygiene.Conclusion This study revealed that the knowledge of the study participants towards menstrual hygiene was high whereas attitude and practice regarding menstrual hygiene was low. Being grade 10 students and having good practice were the associated factors of knowledge. Higher level maternal of education, being grade 10 students and having good knowledge towards menstrual hygiene were the identified associated factors for practicing of menstrual hygiene. Being grade 10 students and age ≥18 were statistically and positively associated with the attitude of menstrual hygiene. Therefore, creating awareness to reproductive health groups, educating their families and parents can change their poor practicing and attitude of menstrual hygiene.
Method for estimating non-study cigarette use among switchers to low nicotine content cigarettes in ambulatory clinical studies
Authors: Zhang Mingda , Edmiston Jeffery , Karles George , Smith Donna 
Published: September 2019

Abstract
Background FDA is considering to establish a product standard to reduce nicotine in cigarettes to make them “minimally addictive or nonaddictive.” FDA has funded many clinical studies where smokers are switched to smoking low nicotine cigarettes to determine a nicotine ceiling that is appropriate for the protection of the public health. Unlike typical clinical trials involving pharmaceuticals or medical devices, ambulatory studies with low nicotine cigarettes face a unique challenge in that conventional nicotine non-study cigarettes are readily available to participants when protocols require them to exclusively use study cigarettes. As a consequence, protocol deviation in non-study product use is a major limitation common in such ambulatory studies, with up to 80 percent of participants using non-study cigarettes during the study. There is no published method for estimating the magnitude of such protocol deviation, i.e., the number of non-study cigarettes smoked by participants, in such studies.Methods We present a method for estimating the magnitude of noncompliance based on the proposition that the level of biomarker of exposure to a smoke constituent is proportional to the amount of the constituent per cigarette and the number of cigarettes smoked by participants. The method estimates the number of non-study cigarettes smoked by participants based on the discrepancies between the yield of smoke constituents (e.g., nicotine) and the level of the corresponding biomarkers measured in a study.Results Data from a confined study confirmed the validity of this method. Under-reporting on the magnitude of non-study cigarette use is widespread across studies using different low nicotine cigarettes. Participants in one of the largest published studies under-reported the number of non-study cigarette used by 79-90%.Conclusions Controlling and accurately estimating non-study cigarette use is critical for ambulatory low nicotine cigarette switching studies to ensure the resulting data can be appropriately evaluated to support science-based regulatory decision-making. In planning future studies, researchers should consider incorporating specific biomarkers that would enable objective assessment of both the prevalence and the magnitude of non-study cigarette use.
Database combinations to retrieve systematic reviews in Overviews of reviews: A methodological study
Authors: Goossen Käthe , Hess Simone , Lunny Carole , Pieper Dawid 
Published: September 2019

Abstract
Background When conducting an Overviews of Reviews on health-related topics it is unclear which combination of bibliographic databases authors should use for searching for systematic reviews. Our goal was to determine which databases indexed the most systematic reviews and identify an optimal database combination for searching systematic reviews. Methods A set of 86 Overviews of Reviews with 1219 included systematic reviews was extracted from a previous study. Indexing of the systematic reviews was assessed in MEDLINE, CINAHL, DARE, Embase, Epistemonikos, PsycINFO, and TRIP. The mean indexing rate (% of indexed systematic reviews) and corresponding 95% confidence interval were calculated for each database individually, as well as for combinations of MEDLINE with other databases and reference checking. Results Indexing of systematic reviews was higher in MEDLINE than in any other single database (mean indexing rate 89.7%; 95% confidence interval [89.0–90.3%]). Combined with reference checking, this value increased to 93.7% [93.2–94.2%]. The best combination of two databases plus reference checking consisted of MEDLINE and Epistemonikos (99.2% [99.0–99.3%]). Stratification by Health Technology Assessment reports (97.7% [96.5–98.9%]) vs. Cochrane overviews (100.0%) vs. non-Cochrane overviews (99.3% [99.1–99.4%]) showed that indexing was only slightly lower for Health Technology Assessment reports. However, MEDLINE, Epistemonikos, and reference checking remained the best combination. Among the 10/1219 systematic reviews not identified by this combination, five were published as websites rather than journals, two were indexed in CINAHL and Embase, and one was indexed in the database ERIC. Conclusions MEDLINE/Epistemonikos, complemented by reference checking, is the best database combination to identify systematic reviews on health-related topics.
Studi Proses Deteksi Objek dalam Analisis Biometrik
Authors: Lionnie Regina , Alaydrus Mudrik 
Published: September 2019

Penelitian pola rambut androgenik pada penelitian ini dilakukan dengan menggunakan metode watershed segmentation berbasis gradien sobel dengan alasan pola rambut androgenik yang diteliti lebih menyerupai pola acak seperti pola pohon dan pertanian serta pola peta jaringan komunikasi dibandingkan dengan pola biometrik pada umumnya seperti pola wajah maupun pola sidik jari. Selain itu untuk mengatasi problem oversegmentation, dilakukan penapisan lolos bawah sebelum proses transformasi watershed menggunakan tapis linear jenis Gaussian dan tapis non linear jenis median. Hasil penelitian menunjukkan dengan menggunakan tapis lolos bawah, hasil deteksi terlihat lebih baik dibandingkan tidak menggunakan tapis. Tapis Gaussian memberikan hasil yang lebih baik dibandingkan tapis median dalam mendeteksi objek rambut androgenik.
Strategi Mempertahankan Brand Knowledge Program Televisi Seputar Indonesia di RCTI
Authors: Oktavianti Roswita , Utami Budi 
Published: September 2019

Brand of television programs has positive equity. It marks by the strength of audience awareness and familiarity with the name of the program. Marketer of television station are considered can create brand knowledge of the program in the audience memory. Nevertheless, as a business, television industries supposed to dynamically follow market need and wants. The brand of the television program which has strength awareness as well as the image on the audience memory will gradually change as much as a media business. This study using a qualitative method and case study as a research strategy to reveals the research problem about how the newsroom team arranged their strategies to maintain brand knowledge to the popularity program. The case study was conducted on RCTI news program “Seputar Indonesia” which has top of mind in audience memory then changed into “Seputar iNews”. This study aiming to enquire how television broadcasting journalist strategies to maintain brand knowledge of their news program. The result is newsroom team have adapted and innovated their process to maintain brand knowledge. They were using main strategic such as maintain their replacement news program typically, maintain brand element whose have audiences top of mind, also using the digital platform. Merek sebuah program televisi seringkali memiliki ekuitas yang positif. Hal ini ditandai dengan kesadaran dan keakraban yang kuat antara audiens dengan nama program televisi tersebut. Pemasar pada stasiun televisi telah mampu menciptakan pengetahuan terhadap merek (brand knowledge) dalam hal ini nama program acara, di dalam memori audiens. Namun, sebagai sebuah bisnis, industri televisi juga harus tetap bergerak dinamis mengikuti keinginan dan kebutuhan pasar. Merek program yang telah memiliki kesadaran dan citra (brand awareness dan brand image) yang kuat di dalam memori audiens, berubah mengikuti kepentingan bisnis media. Dengan menggunakan pendekatan kualitatif dan metode studi kasus, peneliti mengangkat permasalahan bagaimana tim redaksi pemberitaan, menyusun strategi guna mempertahankan brand knowledge sebuah program yang sudah populer di mata penonton. Studi kasus dilakukan terhadap program “Seputar Indonesia” di stasiun televisi RCTI yang sudah melekat di benak konsumen, namun kemudian berubah nama menjadi “Seputar iNews”. Penelitian ini bertujuan untuk mengetahui strategi yang dilakukan oleh pelaku industri media penyiaran televisi dalam mempertahankan brand knowledge sebuah program berita. Hasilnya, tim redaksi pemberitaan sudah melakukan proses adaptasi dan inovasi untuk mempertahankan brand knowledge. Redaksi menggunakan strategi utama yakni mempertahankan ciri khas program berita pengganti, mempertahankan elemen merek yang sudah menjadi top of mind penonton, serta memanfaatkan media digital dan platform lain dalam satu grup perusahaan.
Approximate optimal control synthesis for nonuniform discrete systems with linear quadratic state
Authors: Расина Ирина Викторовна , Фесько Олесь Владимирович 
Published: September 2019

Рассматриваются линейно-квадратические по состоянию неоднородные дискретные системы (НДС). Для указанного класса на основе аналога достаточных условий оптимальности Кротова строится метод приближенного синтеза оптимального управления и приводится иллюстративный пример.
STRUKTUR KOMUNITAS TUMBUHAN PAKU (PTERIDOPHYTA) DI KAWASAN HUTAN KUSU-KUSU KECAMATAN NUSANIWE DAN SOYA KECAMATAN SIRIMAU KOTA AMBON SEBAGAI SUMBANGAN ILMIAH BAGI MATA KULIAH EKOLOGI TUMBUHAN
Authors: Maalalu Jeanne L , Rumahlatu Dominggus 
Published: September 2019

Background: Nail plants (Pteridophyta) are cormus plants whose bodies can be clearly distinguished between roots, stems, and leaves. However, ferns cannot produce seeds because they breed with spores. Nail plants are divided into 4 classes, namely (1) Psilophytinae (ancient nail); (2) Lycopodiinae (wire nail); (3) Equisetinae (horsetail); and (4) Filicinae (true nail). Community structure is a concept that studies species composition or composition and its abundance in a community.
Method: This research is a quantitative descriptive study to reveal information about the community structure of ferns. The study was conducted on July 18, 2018 - August 18, 2018.
Results: The ferns found in the Kusu-Kusu forest area were 10 species and the Soya region as many as 20 species. Overall the types of ferns found in the two study locations were grouped into 2 classes, namely Filicinae / Pteropsida (true nail) and Lycopodiinae (wire nails). The Filicinae / Pteropsida class has a greater number of species, both in the Kusu-Kusu forest area (8 species) and the Soya forest area (13 species). The Lycopodiinae class has a smaller number of species, both in the Kusu-Kusu forest area (2 types), and the Soya forest area (7 species).
Conclusions: 10 ferns were found in the Kusu-Kusu Sereh forest area in Nusaniwe Subdistrict, while in the Soya District of Sirimau District there were 20 species.
STRATEGI KOMUNIKASI CROWDFUNDING PADA KOLASE.COM
Authors: Gogali Venessa Agusta , Muharam Fajar , Fitri Syarif 
Published: September 2019

Crowdfunding is a new method in fundraising activities based online. Moreover, the level of penetration of social media to the community is increasingly high. This makes social activists and academics realize that it is important to study social media communication strategies in crowdfunding activities. There is encouragement to provide an overview of crowdfunding activities. So the author conducted a research on "Crowdfunding Communication Strategy Through Kolase.com Through Case Study on the #BikinNyata Program Through the Kolase.com Website that successfully achieved the target.
Keywords: Strategic of Communication, Crowdfunding, Social Media.