bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of various dose homogeneity indices for treatment of patients with cervix cancer using intensity-modulated radiation therapy technique
Authors: Atiq Atia , Atiq Maria , Iqbal Khalid , Shamsi Quratul Ain , Buzdar Saeed Ahmad 
Published: August 2018

AbstractAimThis study is primarily aimed at the analysis of various dose homogeneity indices (HIs) essential for the evaluation of therapeutic plans by employing intensity-modulated radiation therapy (IMRT) on patients with cervix cancer. Also integral dose (ID) to healthy surrounding organs is computed.Materials and methodsEffectiveness of different HIs (A, B, C, D) was explored for IMRT plans using 15 MV photon beam. In total, 18 patients were selected at random for treatment of cervix cancer, and dose of 5,040 cGy was delivered in 28 equal fractions.ResultsThe study was undertaken to compare four HI formulas and coefficient of determination between each set of HI was known by calculatingR2value. Mean±SD of HI A, HI B, HI C and HI D were 1·12±0·02, 0·13±0·04, 0·10±0·02 and 0·99±0·03, respectively. Mean value of ID for rectum is 3·16 and for bladder is 10·3.FindingsOur data suggested that HI calculated using four formulas provided good plan quality. The results advocate that all the studied HIs can be effectively used for assessment of uniformity inside the target volume. However, values of HI C were closest to ideal value as compared with other three formulas; hence, it is considered a better measure to compute homogeneity of dose within target volume. The ID gives satisfactory results for surrounding normal tissues such as rectum and bladder and significant critical tissue sparing was achieved by using IMRT technique.
The Distributions of Iron Average Charge States in Small Flux Ropes in Interplanetary Space: Clues to Their Twisted Structures
Authors: Huang Jia , Liu Yong C.‐M. , Peng Jun , Qi Zhaohui , Li Hui , Klecker Berndt , Song Hongqiang , Zheng Jinlei , Hu Qiang 
Published: August 2018

AbstractSmall flux ropes (SFRs) have been studied for decades, but their source regions and formation mechanisms are still under debate. In this study, we focus on the formation mechanism of the twisted structures of SFRs. Current research on magnetic clouds suggests five‐type distributions of the time structure of iron average charge states (Q<Fe>), which imply different formation mechanisms of twisted structures. We use a similar method to identify the Q<Fe> types of 25 SFRs. However, only four of these five types of distributions are found among these SFRs. Because different origins of SFRs are characteristically affecting the formation of Q<Fe> types, the possible source regions of these SFRs are distinguished. With additional compositional parameters, SFRs are reconfirmed to originate from two types of source regions: the solar corona and the interplanetary medium. Based on these results, our analysis indicates that the twisted structures of SFRs originating from the solar corona may be formed predominately during eruptions. SFRs originating from interplanetary space are related to complex magnetic reconnection processes, which may result in intricate Q<Fe> distributions due to the reconstruction of magnetic field topology.
Interflow Is Not Binary: A Continuous Shallow Perched Layer Does Not Imply Continuous Connectivity
Authors: Klaus Julian , Jackson C. Rhett 
Published: August 2018

AbstractHillslopes exert critical controls on the quality and quantity of downstream waters. To understand and model dominant headwater catchment processes, we need to estimate the relative importance of different runoff generation processes. In this work we analyze published data from studies of 17 hillslopes from a range of landscapes to better understand the relative role of interflow, that is, shallow lateral subsurface flow moving over a layer impeding percolation, in streamflow generation. For each slope, we calculated downslope interflow travel distances, that is, the potential distance a water parcel travels downslope above an impeding layer until it percolates into the impeding layer. The downslope travel distances for the 17 hillslopes ranged from around 1 m to several hundred meters. The vector analysis of downslope travel distances revealed that all but three hillslopes had slope lengths that were much longer than downslope travel distances. For the remaining 14 cases we could show that most water perched above a shallow impeding layer percolates through the impeding layer before reaching the valley or the stream channel. Thus, interflow usually contributes directly to valley water or streamflow only from the lower portions of the hillslope in most landscapes. A critical finding of our analysis is that a continuously perched saturated zone with downslope flow does not imply continuous connectivity to the stream. Such a continuous connectivity is the exception rather than the rule in most landscapes. Future hillslope and headwater processes and modeling studies will need to account for this.
Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder
Authors: Qian Xing , Loo Beatrice Rui Yi , Castellanos Francisco Xavier , Liu Siwei , Koh Hui Li , Poh Xue Wei Wendy , Krishnan Ranga , Fung Daniel , Chee Michael WL , Guan Cuntai , Lee Tih-Shih , Lim Choon Guan , Zhou Juan 
Published: August 2018

AbstractA brain-computer-interface (BCI)-based attention training game system has shown promise for treating attention deficit/hyperactivity disorder (ADHD) children with inattentive symptoms. However, little is known about brain network organizational changes underlying behavior improvement following BCI-based training. To cover this gap, we aimed to examine the topological alterations of large-scale brain functional networks induced by the 8-week BCI-based attention intervention in ADHD boys using resting-state functional magnetic resonance imaging method. Compared to the non-intervention (ADHD-NI) group, the intervention group (ADHD-I) showed greater reduction of inattention symptoms accompanied with differential brain network reorganizations after training. Specifically, the ADHD-NI group had increased functional connectivity (FC) within the salience/ventral attention network (SVN) and increased FC between task-positive networks (including the SVN, dorsal attention (DAN), somatomotor, and executive control network) and subcortical regions; in contrast ADHD-I group did not have this pattern. In parallel, ADHD-I group had reduced degree centrality and clustering coefficient as well as increased closeness in task-positive and the default mode networks (prefrontal regions) after the training. More importantly, these reduced local functional processing mainly in the SVN were associated with less inattentive/internalizing problems after 8-week BCI-based intervention across ADHD patients. Our findings suggest that the BCI-based attention training facilitates behavioral improvement in ADHD children by reorganizing brain functional network from more regular to more random configurations, particularly renormalizing salience network processing. Future long-term longitudinal neuroimaging studies are needed to develop the BCI-based intervention approach to promote brain maturation in ADHD.
Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism
Authors: Connery Kathleen , Tippett Marie , Delhey Leanna M. , Rose Shannon , Slattery John C. , Kahler Stephen G. , Hahn Juergen , Kruger Uwe , Cunningham Madeleine W. , Shimasaki Craig , Frye Richard E. 
Published: August 2018

AbstractThe identification of brain-targeted autoantibodies in children with autism spectrum disorder (ASD) raises the possibility of autoimmune encephalopathy (AIE). Intravenous immunoglobulin (IVIG) is effective for AIE and for some children with ASD. Here, we present the largest case series of children with ASD treated with IVIG. Through an ASD clinic, we screened 82 children for AIE, 80 of them with ASD. IVIG was recommended for 49 (60%) with 31 (38%) receiving the treatment under our care team. The majority of parents (90%) reported some improvement with 71% reporting improvements in two or more symptoms. In a subset of patients, Aberrant Behavior Checklist (ABC) and/or Social Responsiveness Scale (SRS) were completed before and during IVIG treatment. Statistically significant improvement occurred in the SRS and ABC. The antidopamine D2L receptor antibody, the anti-tubulin antibody and the ratio of the antidopamine D2L to D1 receptor antibodies were related to changes in the ABC. The Cunningham Panel predicted SRS, ABC, parent-based treatment responses with good accuracy. Adverse effects were common (62%) but mostly limited to the infusion period. Only two (6%) patients discontinued IVIG because of adverse effects. Overall, our open-label case series provides support for the possibility that some children with ASD may benefit from IVIG. Given that adverse effects are not uncommon, IVIG treatment needs to be considered cautiously. We identified immune biomarkers in select IVIG responders but larger cohorts are needed to study immune biomarkers in more detail. Our small open-label exploratory trial provides evidence supporting a neuroimmune subgroup in patients with ASD.
HCV-associated exosomes promote myeloid-derived suppressor cell expansion via inhibiting miR-124 to regulate T follicular cell differentiation and function
Authors: Wang Lin , Cao Dechao , Wang Ling , Zhao Juan , Nguyen Lam Nhat , Dang Xindi , Ji Yingjie , Wu Xiao Y. , Morrison Zheng D. , Xie Qian , El Gazzar Mohamed , Ning Shunbin , Moorman Jonathan P. , Yao Zhi Q. 
Published: August 2018

AbstractVirus-infected cells can regulate non-permissive bystander cells, but the precise mechanisms remain incompletely understood. Here we report that this process can be mediated by transfer of viral RNA-loaded exosomes shed from infected cells to myeloid-derived suppressor cells (MDSCs), which in turn regulate the differentiation and function of T cells during viral infection. Specifically, we demonstrated that patients with chronic hepatitis C virus (HCV) infection exhibited significant increases in T follicular regulatory (TFR) cells and decreases in T follicular helper (TFH) cells. These MDSC-mediated T-cell dysregulations resulted in an increased ratio of TFR/TFH and IL-10 production in peripheral blood. Specifically, co-culture of MDSCs derived from HCV patients with healthy peripheral blood mononuclear cells (PBMCs) induced expansion of TFR, whereas depletion of MDSCs from PBMCs of HCV patients reduced the increases in TFR frequency and IL-10 production, and promoted the differentiation of IFN-γ-producing TFH cells. Importantly, we found that exosomes isolated from the plasma of HCV patients and supernatant of HCV-infected hepatocytes could drive monocytic myeloid cell differentiation into MDSCs. These exosomes were enriched in tetraspanins, such as CD63 and CD81, and contained HCV RNA, but exosomes isolated from patients with antiviral treatment contained no HCV RNA and could not induce MDSC differentiation. Notably, these HCV RNA-containing exosomes (HCV-Exo) were sufficient to induce MDSCs. Furthermore, incubation of healthy myeloid cells with these HCV-Exo inhibited the expression of miR−124, whereas reconstitution of PBMCs with miR−124 abolished the effects of HCV−Exo on MDSC induction. Taken together, these results indicate that HCV-associated exosomes can transfer immunomodulatory viral RNA from infected cells to neighboring immune cells and trigger MDSC expansion, which subsequently promotes TFR differentiation and inhibits TFH function. This study reveals a previously unrecognized path that represents a novel mechanism of immune dysregulation during chronic viral infection.
Observation of bosonic condensation in a hybrid monolayer MoSe2-GaAs microcavity
Authors: Waldherr Max , Lundt Nils , Klaas Martin , Betzold Simon , Wurdack Matthias , Baumann Vasilij , Estrecho Eliezer , Nalitov Anton , Cherotchenko Evgenia , Cai Hui , Ostrovskaya Elena A. , Kavokin Alexey V. , Tongay Sefaattin , Klembt Sebastian , Höfling Sven , Schneider Christian 
Published: August 2018

AbstractBosonic condensation belongs to the most intriguing phenomena in physics, and was mostly reserved for experiments with ultra-cold quantum gases. More recently, it became accessible in exciton-based solid-state systems at elevated temperatures. Here, we demonstrate bosonic condensation driven by excitons hosted in an atomically thin layer of MoSe2, strongly coupled to light in a solid-state resonator. The structure is operated in the regime of collective strong coupling between a Tamm-plasmon resonance, GaAs quantum well excitons, and two-dimensional excitons confined in the monolayer crystal. Polariton condensation in a monolayer crystal manifests by a superlinear increase of emission intensity from the hybrid polariton mode, its density-dependent blueshift, and a dramatic collapse of the emission linewidth, a hallmark of temporal coherence. Importantly, we observe a significant spin-polarization in the injected polariton condensate, a fingerprint for spin-valley locking in monolayer excitons. Our results pave the way towards highly nonlinear, coherent valleytronic devices and light sources.
The first transmembrane region of complement component-9 acts as a brake on its self-assembly
Authors: Spicer Bradley A. , Law Ruby H. P. , Caradoc-Davies Tom T. , Ekkel Sue M. , Bayly-Jones Charles , Pang Siew-Siew , Conroy Paul J. , Ramm Georg , Radjainia Mazdak , Venugopal Hariprasad , Whisstock James C. , Dunstone Michelle A. 
Published: August 2018

AbstractComplement component 9 (C9) functions as the pore-forming component of the Membrane Attack Complex (MAC). During MAC assembly, multiple copies of C9 are sequentially recruited to membrane associated C5b8 to form a pore. Here we determined the 2.2 Å crystal structure of monomeric murine C9 and the 3.9 Å resolution cryo EM structure of C9 in a polymeric assembly. Comparison with other MAC proteins reveals that the first transmembrane region (TMH1) in monomeric C9 is uniquely positioned and functions to inhibit its self-assembly in the absence of C5b8. We further show that following C9 recruitment to C5b8, a conformational change in TMH1 permits unidirectional and sequential binding of additional C9 monomers to the growing MAC. This mechanism of pore formation contrasts with related proteins, such as perforin and the cholesterol dependent cytolysins, where it is believed that pre-pore assembly occurs prior to the simultaneous release of the transmembrane regions.
Ultra-extensible ribbon-like magnetic microswarm
Authors: Yu Jiangfan , Wang Ben , Du Xingzhou , Wang Qianqian , Zhang Li 
Published: August 2018

AbstractVarious types of structures self-organised by animals exist in nature, such as bird flocks and insect swarms, which stem from the local communications of vast numbers of limited individuals. Through the designing of algorithms and wireless communication, robotic systems can emulate some complex swarm structures in nature. However, creating a swarming robotic system at the microscale that embodies functional collective behaviours remains a challenge. Herein, we report a strategy to reconfigure paramagnetic nanoparticles into ribbon-like swarms using oscillating magnetic fields, and the mechanisms are analysed. By tuning the input fields, the microswarm can perform a reversible elongation with an extremely high aspect ratio, as well as splitting and merging. Moreover, we investigate the behaviours of the microswarm when it encounters solid boundaries, and demonstrate that under navigation, the colloidal microswarm passes through confined channel networks towards multiple targets with high access rates and high swarming pattern stability.
Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus
Authors: Kim Doo Hyun , Park Eun-Sook , Lee Ah Ram , Park Soree , Park Yong Kwang , Ahn Sung Hyun , Kang Hong Seok , Won Ju Hee , Ha Yea Na , Jae ByeongJune , Kim Dong-Sik , Chung Woo-Chang , Song Moon Jung , Kim Kee-Hwan , Park Seung Hwa , Kim Soo-Hyun , Kim Kyun-Hwan 
Published: August 2018

AbstractCytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-γ in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription and replication. The gamma isoform of IL-32 (IL-32γ) inhibits viral enhancer activities by downregulating liver-enriched transcription factors. Our data are validated in both an in vivo HBV mouse model and primary human hepatocytes. This study thus suggests that IL-32γ functions as intracellular effector in hepatocytes for suppressing HBV replication to implicate a possible mechanism of non-cytopathic viral clearance.
Resolution of chronic inflammatory disease: universal and tissue-specific concepts
Authors: Schett Georg , Neurath Markus F. 
Published: August 2018

AbstractInflammation and its resolution is under-studied in medicine despite being essential for understanding the development of chronic inflammatory disease. In this review article, we discuss the resolution of inflammation in both a biological and translational context. We introduce the concept of impaired resolution leading to diseases like rheumatoid arthritis, Crohn's disease, and asthma, as well as the cellular and molecular components that contribute to resolution of joint, gut, and lung inflammation, respectively. Finally, we discuss potential intervention strategies for fostering the resolution process, and their implications for the therapy of inflammatory diseases.
Understanding voltage decay in lithium-excess layered cathode materials through oxygen-centred structural arrangement
Authors: Myeong Seungjun , Cho Woongrae , Jin Wooyoung , Hwang Jaeseong , Yoon Moonsu , Yoo Youngshin , Nam Gyutae , Jang Haeseong , Han Jung-Gu , Choi Nam-Soon , Kim Min Gyu , Cho Jaephil 
Published: August 2018

AbstractLithium-excess 3d-transition-metal layered oxides (Li1+xNiyCozMn1−x−y−zO2, >250 mAh g−1) suffer from severe voltage decay upon cycling, which decreases energy density and hinders further research and development. Nevertheless, the lack of understanding on chemical and structural uniqueness of the material prevents the interpretation of internal degradation chemistry. Here, we discover a fundamental reason of the voltage decay phenomenon by comparing ordered and cation-disordered materials with a combination of X-ray absorption spectroscopy and transmission electron microscopy studies. The cation arrangement determines the transition metal-oxygen covalency and structural reversibility related to voltage decay. The identification of structural arrangement with de-lithiated oxygen-centred octahedron and interactions between octahedrons affecting the oxygen stability and transition metal mobility of layered oxide provides the insight into the degradation chemistry of cathode materials and a way to develop high-energy density electrodes.
Opioids prevent regeneration in adult mammals through inhibition of ROS production
Authors: Labit Elodie , Rabiller Lise , Rampon Christine , Guissard Christophe , André Mireille , Barreau Corinne , Cousin Béatrice , Carrière Audrey , Eddine Mohamad Ala , Pipy Bernard , Pénicaud Luc , Lorsignol Anne , Vriz Sophie , Dromard Cécile , Casteilla Louis 
Published: August 2018

AbstractInhibition of regeneration and induction of tissue fibrosis are classic outcomes of tissue repair in adult mammals. Here, using a newly developed model of regeneration in adult mammals i.e. regeneration after massive resection of an inguinal fat pad, we demonstrate that both endogenous and exogenous opioids prevent tissue regeneration in adults, by inhibiting the early production of reactive oxygen species (ROS) that generally occurs after lesion and is required for regeneration. These effects can be overcome and regeneration induced by the use of an opioid antagonist. The results obtained in both our new model and the gold standard adult zebrafish demonstrate that this mechanism can be considered as a general paradigm in vertebrates. This work clearly demonstrates that ROS is required for tissue regeneration in adult mammals and shows the deleterious effect of opioids on tissue regeneration through the control of this ROS production. It thus raises questions about opioid-based analgesia in perioperative care.
Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds
Authors: Vishwakarma Vikalp , New Jacob , Kumar Dhruv , Snyder Vusala , Arnold Levi , Nissen Emily , Hu Qingting , Cheng Nikki , Miller David , Thomas Ahia Rael , Shnayder Yelizaveta , Kakarala Kiran , Tsue Terance Ted , Girod Douglas A. , Thomas Sufi Mary 
Published: August 2018

AbstractHead and neck squamous cell carcinoma (HNSCC) is associated with low survival, and the current aggressive therapies result in high morbidity. Nutraceuticals are dietary compounds with few side effects. However, limited antitumor efficacy has restricted their application for cancer therapy. Here, we examine combining nutraceuticals, establishing a combination therapy that is more potent than any singular component, and delineate the mechanism of action. Three formulations were tested: GZ17-S (combined plant extracts from Arum palaestinum, Peganum harmala and Curcuma longa); GZ17-05.00 (16 synthetic components of GZ17-S); and GZ17-6.02 (3 synthetic components of GZ17S; curcumin, harmine and isovanillin). We tested the formulations on HNSCC proliferation, migration, invasion, angiogenesis, macrophage viability and infiltration into the tumor and tumor apoptosis. GZ17-6.02, the most effective formulation, significantly reduced in vitro assessments of HNSCC progression. When combined with cisplatin, GZ17-6.02 enhanced anti-proliferative effects. Molecular signaling cascades inhibited by GZ17-6.02 include EGFR, ERK1/2, and AKT, and molecular docking analyses demonstrate GZ17-6.02 components bind at distinct binding sites. GZ17-6.02 significantly inhibited growth of HNSCC cell line, patient-derived xenografts, and murine syngeneic tumors in vivo (P < 0.001). We demonstrate GZ17-6.02 as a highly effective plant extract combination and pave the way for future clinical application in HNSCC.
Maximal distant entanglement in Kitaev tube
Authors: Wang P. , Lin S. , Zhang G. , Song Z. 
Published: August 2018

AbstractWe study the Kitaev model on a finite-size square lattice with periodic boundary conditions in one direction and open boundary conditions in the other. Based on the fact that the Majorana representation of Kitaev model is equivalent to a brick wall model under the condition t = Δ = μ, this system is shown to support perfect Majorana bound states which is in strong localization limit. By introducing edge-mode fermionic operator and pseudo-spin representation, we find that such edge modes are always associated with maximal entanglement between two edges of the tube, which is independent of the size of the system.