bluuebunny/crossref_metadata_2025_split huggingface dataset:
NFATc3 controls tumour growth by regulating proliferation and migration of human astroglioma cells
Authors: Urso Katia , Fernández Andrés , Velasco Patricia , Cotrina Javier , de Andrés Belén , Sánchez-Gómez Pilar , Hernández-Laín Aurelio , Hortelano Sonsoles , Redondo Juan Miguel , Cano Eva 
Published: June 2019

AbstractCalcium/Calcineurin/Nuclear Factor of Activated T cells (Ca/CN/NFAT) signalling pathway is the main calcium (Ca2+) dependent signalling pathway involved in the homeostasis of brain tissue. Here, we study the presence of NFATc members in human glioma by using U251 cells and a collection of primary human glioblastoma (hGB) cell lines. We show that NFATc3 member is the predominant member. Furthermore, by using constitutive active NFATc3 mutant and shRNA lentiviral vectors to achieve specific silencing of this NFATc member, we describe cytokines and molecules regulated by this pathway which are required for the normal biology of cancer cells. Implanting U251 in an orthotopic intracranial assay, we show that specific NFATc3 silencing has a role in tumour growth. In addition NFATc3 knock-down affects both the proliferation and migration capacities of glioma cellsin vitro. Our data open the possibility of NFATc3 as a target for the treatment of glioma.
Noisy galvanic vestibular stimulation modulates spatial memory in young healthy adults
Authors: Hilliard Danica , Passow Susanne , Thurm Franka , Schuck Nicolas W. , Garthe Alexander , Kempermann Gerd , Li Shu-Chen 
Published: June 2019

AbstractHippocampal and striatal circuits play important roles in spatial navigation. These regions integrate environmental information and receive intrinsic afferent inputs from the vestibular system. Past research indicates that galvanic vestibular stimulation (GVS) is a non-invasive technique that modulates hippocampal and striatal activities. There are also evidences for enhanced motor and cognitive functions through GVS. This study extends previous research to investigate whether noisy GVS may improve hippocampal- and striatal-associated aspects of spatial navigation performance. Using a virtual navigation task, we examined effects of noisy GVS on spatial learning and memory. To probe the participants’ sensitivity to hippocampal- or striatal-associated spatial information, we either enlarged the virtual environment’s boundary or replaced an intra-environmental location cue, respectively. Noisy GVS or sham stimulation was applied online during the learning phase in a within-subject crossover design. The results showed that noisy GVS enhanced spatial learning and the sensitivity foremost to hippocampal-dependent spatial information both in males and females. Individual differences in spatial working memory capacity moderated the effects of GVS, with individuals with lower capacity benefitting more from the stimulation. Furthermore, sex-related differences in GVS effects on the two forms of spatial representations may reflect differences between males and females in preferred spatial strategies.
Adult Pgf−/− mice behaviour and neuroanatomy are altered by neonatal treatment with recombinant placental growth factor
Authors: Kay Vanessa R. , Cahill Lindsay S. , Hanif Anas , Sled John G. , Carmeliet Peter , Tayade Chandrakant , Croy B. Anne 
Published: June 2019

AbstractOffspring of preeclamptic pregnancies have cognitive alterations. Placental growth factor (PGF), is low in preeclampsia; reduced levels may affect brain development. PGF-null mice differ from normal congenic controls in cerebrovasculature, neuroanatomy and behavior. Using brain imaging and behavioral testing, we asked whether developmentally asynchronous (i.e. neonatal) PGF supplementation alters the vascular, neuroanatomic and/or behavioral status ofPgf−/−mice at adulthood. C57BL/6-Pgf−/−pups were treated intraperitoneally on postnatal days 1–10 with vehicle or PGF at 10 pg/g, 70 pg/g or 700 pg/g. These mice underwent behavioral testing and perfusion for MRI and analysis of retinal vasculature. A second cohort of vehicle- or PGF-treated mice was perfused for micro-CT imaging. 10 pg/g PGF-treated mice exhibited less locomotor activity and greater anxiety-like behavior relative to vehicle-treated mice. Depressive-like behavior showed a sex-specific, dose-dependent decrease and was lowest in 700 pg/g PGF-treated females relative to vehicle-treated females. Spatial learning did not differ. MRI revealed smaller volume of three structures in the 10 pg/g group, larger volume of seven structures in the 70 pg/g group and smaller volume of one structure in the 700 pg/g group. No cerebral or retinal vascular differences were detected. Overall, neonatal PGF replacement altered behavior and neuroanatomy of adultPgf−/−mice.
Roles of the procollagen C-propeptides in health and disease
Authors: Hulmes David J.S. 
Published: June 2019

Abstract
The procollagen C-propeptides of the fibrillar collagens play key roles in the intracellular assembly of procollagen molecules from their constituent polypeptides chains, and in the extracellular assembly of collagen molecules into fibrils. Here we review recent advances in understanding the molecular mechanisms controlling C-propeptide trimerization which have revealed the importance of inter-chain disulphide bonding and a small number of charged amino acids in the stability and specificity of different types of chain association. We also show how the crystal structure of the complex between the C-propeptide trimer of procollagen III and the active fragment of procollagen C-proteinase enhancer-1 leads to a detailed model for accelerating release of the C-propeptides from procollagen by bone morphogenetic protein-1 and related proteinases. We then discuss the effects of disease-related missense mutations in the C-propeptides in relation to the sites of these mutations in the three-dimensional structure. While in general there is a good correlation between disease severity and structure-based predictions, there are notable exceptions, suggesting new interactions involving the C-propeptides yet to be characterized. Mutations affecting proteolytic release of the C-propeptides from procollagen are discussed in detail. Finally, the roles of recently discovered interaction partners for the C-propeptides are considered during fibril assembly and cross-linking.
Chemical and radiative transfer modeling of propylene oxide
Authors: Das Ankan , Gorai Prasanta , Chakrabarti Sandip K. 
Published: June 2019

Context.The recent identification of the first complex chiral molecule, propylene oxide (PrO), in space opens up a new window to further study the origin of homochirality on the Earth. There are some recent studies to explain the formation of PrO however additional studies on the formation of this species are needed for better understanding.Aims.We seek to prepare a complete reaction network to study the formation of propylene oxide in the astrophysically relevant conditions. Based on our results, a detailed radiative transfer modeling has been carried out to propose some more transitions that would potentially be targeted in the millimeter wave domain.Methods.A gas-grain chemical network was used to explain the observed abundance of PrO in a cold shell surrounding the high-mass star-forming region of Sgr B2. Quantum chemical calculations were employed to study various reaction parameters and to compute multiple vibrational frequencies of PrO.Results.To model the formation of PrO in the observed region, we considered a dark cloud model. Additionally, we used a model to check the feasibility of forming PrO in the hot core region. Some potential transitions in the millimeter wave domain are predicted that could be useful for the future astronomical detection. We used radiative transfer modeling to extract the physical condition that might be useful to know the properties of the source in detail. Moreover, we provided vibrational transitions of PrO, which could be very useful for the future detection of PrO by the upcomingJames WebbSpace Telescope.
Proposition d’un indice définissant les indications médicales d’une disjonction intermaxillaire chez un sujet en période de croissance
Authors: Salagnac Jean-Michel 
Published: June 2019

Introduction : La disjonction intermaxillaire (DIM) ou expansion rapide maxillaire (ERM) est couramment utilisée par les orthodontistes pour la correction des déficits transversaux maxillaires chez les enfants et les adolescents présentant des anomalies transversales de l’occlusion dentaire et une voute palatine profonde. Cette insuffisance maxillaire transversale est souvent associée à des anomalies squelettiques antéro-postérieures de classe II ou de classe III, à des anomalies verticales et à des troubles fonctionnels, notamment de la ventilation. Elle consiste à séparer, en deux à trois semaines, les deux maxillaires droit et gauche, à l’aide d’un dispositif d’expansion fixé sur un appui dentaire ou osseux. Curieusement, les orthodontistes qui emploient souvent des dispositifs d’expansion utilisent de façon très inégale cette méthode, bien qu’elle soit le seul traitement efficace de la véritable insuffisance transversale maxillaire (ITM). Le diagnostic clinique des ITM est difficile à établir, ce qui ne permet pas de poser l’indication de la DIM avec précision. Matériels et méthodes : À partir de l’observation de la sémiologique clinique et radiologique, et de traitement de très nombreux patients, pendant plus de 45 années, il est possible de proposer un indice de diagnostic qui précise les indications de cette thérapeutique. Résultats : Cet indice de diagnostic, de maniement facile et rapide, est utilisable aisément en pratique quotidienne. Composé de quatre groupes d’items, il permet de prendre en compte tous les éléments nécessaires à la pose de l’indication médicale de la disjonction intermaxillaire. Il permet également d’évaluer son efficacité en comparant les scores avant et après traitement. Discussion : Bien que perfectible, il n’existe pas actuellement d’outil diagnostique comparable. Cet indice a pour objectif de préciser l’indication médicale de cette méthode et de réduire les disparités d’emploi de cette thérapeutique.
Dysfonctions somatiques du rachis cervical et traitement multi-attache : une étude transversale sur 145 sujets
Authors: Chane Loïc , Kily Jean-Pascal , Marangelli Gianni , Gebeile-Chauty Sarah 
Published: June 2019

Objectifs : Le but de cette étude transversale effectuée en aveugle est d’évaluer l’influence d’un appareil orthodontique fixe sur le rachis cervical. Matériels et méthodes : Le nombre et la gravité des dysfonctions somatiques (altération dans la fonction d’un élément constituant le système somatique ou DS) du rachis cervical ont été étudiés chez des patients classés en trois groupes : sujets sans traitement orthodontique (groupe 1), sujets portant un appareil orthodontique fixe (groupe 2) et sujets en contention après la dépose de l’appareil orthodontique fixe (groupe 3) et comparés grâce au test du khi2. Résultats : Un total de 145 patients âgés de 6 à 17 ans ont été inclus. Il y avait plus de DS dans le groupe 2 (p = 0,006) que dans le groupe 1. Il n’y avait pas de différence entre le groupe 1 et 3 (p = 0,2), entre le groupe 2 et 3 (p = 0,4) et entre les trois groupes (p = 0,6) concernant la sévérité des DS. Conclusion : Les troubles cervicaux ne devraient pas être imputés à long terme au traitement multi-attache puisqu’une fois le traitement orthodontique actif fini, les DS ne sont pas significativement augmentées par rapport au groupe contrôle. Ces résultats incitent à effectuer une étude pour évaluer le bénéfice d’un suivi ostéopathique des patients à risque après la pose de l’appareil multi-attache.
Balint-Gruppen-Arbeit ist Beziehungsarbeit: Was heißt hier ‚Beziehung‘?
Authors: Wittenberger G. 
Published: June 2019

ZusammenfassungEs wird versucht zu umreißen, was „Beziehung“ im professionellen Zusammenhang sein kann. In Folge der Komplexität der Beziehungen in der Balint-Gruppen-Arbeit zeigt sich, dass das Beziehungsgeschehen nicht nur zwischen „Arzt/Supervisor“ und „Patient/Supervisand“ zu reflektieren ist, sondern auch die Gruppendynamik in ihrer Bedeutung als Spiegelungsphänomen für den vorgetragenden „Fall“. Das bedeutet, dass die Beziehungen der Gruppenteilnehmer berücksichtigt werden müssen, soweit sie sich als blockierend für die gemeinsame Arbeit am „Fall“ auswirken. Um einen Zugang zu der Vielschichtigkeit der Phänomene zu bekommen, ist es erforderlich, Zeit und Raum (Setting) so zu gestalten, dass Balint-Gruppen-Arbeit stattfinden kann. Die Arbeit in, mit, durch und an diesen Beziehungen wird als eine Herausforderung in zweifacher Hinsicht begriffen: einmal als kollegiale Herausforderung, das gemeinsame Erleben des „Nicht-Wissens“, des „Verwickelns“ zu reflektieren, und zum anderen, auf schnelle lösungsorientierte Ratschläge oder Handlungen zu verzichten.
Morphometric Analysis of Proximal End of the Tibia
Authors: Ahmad Nadia , Singh Deepa , Dubey Aksh , Jethani S. L. 
Published: June 2019

Abstract
Background Total knee arthroplasty and unicompartmental knee arthroplasty are frequently done procedures for the treatment of various forms of arthritis and knee injuries. The knee prosthesis, which is used for these procedures, requires adequate sizing specific to the population. Morphometric parameters of upper end of the tibia can be used to guide treatment and monitor outcome of total knee replacement surgeries. Information regarding morphometry of upper end of the tibia is important as it provides reliable method of assessing knee deformity. This article assesses different morphometric parameters of condylar and intercondylar surface of the tibia and to compile the results, analyze, and formulate a baseline data for future studies with relevance to Indian population.
Materials and Methods The study group comprised of 60 adult human dry and processed tibia of both sides which are grossly normal and complete, obtained from the Department of Anatomy, Himalayan Institute of Medical Sciences. Morphometric measurements of the medial condyle, lateral condyle, and intercondylar area of tibia were recorded with vernier calipers with a least count of 0.01 mm. The dimensions were summarized as mean ± standard deviation. A p-value of < 0.05 was considered significant.
Result Mediolateral and anteroposterior length were 66.33 and 42.52 mm, respectively.
Conclusion Anatomical profile of tibial condyle for Indians is smaller, hence highlighting the need for sizing of prosthesis specific to the population in question.
Change in Shear Elastic Modulus of Thigh Muscle by Changing Muscle Length Using Ultrasound Shear Wave Elastography in Beagle Dogs
Authors: Shimizu Miki , Ito Yu 
Published: June 2019

Objectives This study investigated the relationship between the change in the shear elastic modulus and the change in muscle length using ultrasound shear wave elastography.
Study Design Four thigh muscles, cranial part of the sartorius, vastus lateralis, biceps femoris and semitendinosus muscles, of 21 pelvic limbs in 12 clinically healthy Beagle dogs were used. The muscle length was estimated using a radiograph and the flexed and extended positions of the coxofemoral and stifle joints, respectively. The shear elastic modulus (kPa) was measured in two joint positions using ultrasound shear wave elastography. Shear elastic modulus was expressed as median of 10 consecutive measurements. The percentage change of elastic modulus was calculated from the shear elastic modulus in elongated condition and pre-elongated condition of muscle.
Results The elastic modulus of all muscles increased when the muscle was elongated. The shear elastic modulus for both joint positions and the percentage change of the shear elastic modulus (%) in cranial part of the sartorius were highest in all muscles. Intra-observer correlation coefficient (1.2) was 0.75 to 0.96 and intra-observer correlation coefficients (2.2) was 0.46 to 0.96.
Conclusion This study revealed that the shear elastic modulus of muscle was changed by the change in muscle length and increased when the muscle was elongated. Ultrasound shear wave elastography can be used to assess the elastic properties of canine muscle.
La paradoja descriptiva de la traducción y su ilustración a través de un análisis de la subtitulación de The Wire
Authors: Ortiz García Javier 
Published: June 2019

Abstract
Over recent decades, translation studies have witnessed how descriptive studies have taken over prescriptive approaches. This essay deals with this subject, proposing that the two theoretical perspectives are not so far apart as may be inferred from the literature available and that, paradoxically, they are very close as regards their ultimate objectives. To develop this proposal, we establish a typology of hypotheses that a translation study should consider from the beginning; once the proposed hypothesis is checked, the implementation of the strategies for the given translation at stake seems to be the same as for descriptive approaches. In order to illustrate this apparent paradox, we observe and analyze some examples of the translated subtitles into Spanish of the first season of the acclaimed American series The Wire, paying special attention to the informal use of language in the dialogues. Following the theoretical frame designed in the first part of the essay, we first analyze the available subtitles in Spanish, and then propose some details pertaining to the translation that might perhaps have permitted a better reception of the series in the target system, that is the Spanish-speaking system.
Deep memory during the Crimean crisis
Authors: Spiessens Anneleen 
Published: June 2019

Abstract
In Russian media and statements by Kremlin officials, the current war in Ukraine is regularly imagined through the lens of World War II. Protection of ethnic kins in Crimea against their local “fascist” government is even invoked to justify the annexation of the peninsula in March 2014. A narrative analysis of a corpus consisting of 770 English and French newspaper articles and 39 translations demonstrates how the Russian news translation website InoSMI re-interprets Western reports on the Crimean crisis by triggering “deep memory” (Wertsch 2008a, 2008b) of the Great Patriotic War. Through selective appropriation, translation shifts and manipulation of visual material, the internet portal highlights particular aspects of the WW II narrative template that activate simplified schemata opposing Russian “patriots” and Ukrainian “fascists.” The paper thus underscores the role of news translation as ideological memory-work.
Translation in the Kurdish magazine Hawar
Authors: Çelik Bilal 
Published: June 2019

Abstract
This article explores the role of translation in forming and legitimizing a Kurdish cultural identity through diverse renderings in the Kurdish magazine Hawar launched by Celadet Alî Bedirxan between 1932 and 1943 in Damascus. It also sheds light on the tense relationship between Kurdish and Turkish cultures, which also impacted the translational and cultural aspects of the periodical. This relation has relatively improved from the late twentieth century onwards. My argument is that the composition of Hawar as a whole and translations in the periodical aimed to form a Kurdish cultural identity and legitimize it both for the Kurds and worldwide audience in the historical conditions of the 1930s and 1940s. This article will point out the pivotal position of translation in the composition of Hawar and the role played by Celadet Alî Bedirxan as an agent in this undertaking.
Serialized literary translation in Hong Kong Chinese newspapers
Authors: Li Bo 
Published: June 2019

AbstractChina experienced one of the great “waves of translation” and a boom of Chinese-language newspapers around the turn of the twentieth century. It is not coincidence that many of the translated works were initially serialized in these newspapers. Although translations in these newspapers, especially those in Shanghai, have gained increasing attention, those in Hong Kong have remained largely unexplored. This paper addresses this gap and the specific subgenre that has received scant attention: serialized translated literature. In particular, the paper focuses on the case study ofThe Chinese Mail, examining spatial and temporal dimensions of newspaper serialization of translated literary works in Hong Kong.
Value of auditory perception of alphabet letters test (Arabic standardized version) in evaluation of Arabic speaking CI children
Authors: Mekki S. , Quriba A. , Gad N. 
Published: June 2019

Background:
Cochlear implant (CI) is a hearing device that helps hearing impaired children who did not benefit from conventional hearing aids to restore a satisfactory level of auditory sensation. The proper verification of their auditory speech and language performance helps gain the best outcomes. Speech perception tests are basic assessment tools. They are considered as supra-threshold tests that use different speech materials that are reliable for hearing impaired children.

Objectives:
The aim of this study is to assess the correlation between the different speech perception tests and auditory skills, language acquisition and speech parameters for cases with CI children in Zagazig University Hospitals. This will help develop an appropriate battery for verification of CI children.

Design:
This study was applied on 21 children with CI who had implanted before the data collection period. For all participants aided thresholds, APAL, WIPI and PBKG tests were done in the audio-vestibular medicine unit for assessment of audiological outcomes. Assessment of auditory skills, language acquisition and speech parameters were done in the Phoniatric Unit. The results were collected and statistically analyzed.

Results:
There was a strong positive correlation between APAL and TLA, auditory skills and intelligibility of speech, which was superior to other speech perception tests.

Conclusion:
APAL can be used as a reliable speech discrimination test that can anticipate the progress in different skills of pre-lingual CI children.
The theory of scanning quantum dot microscopy
Authors: Wagner Christian , Tautz F Stefan 
Published: June 2019

Abstract
Electrostatic forces are among the most common interactions in nature and omnipresent at the nanoscale. Scanning probe methods represent a formidable approach to study these interactions locally. The lateral resolution of such images is, however, often limited as they are based on measuring the force (gradient) due to the entire tip interacting with the entire surface. Recently, we developed scanning quantum dot microscopy (SQDM), a new technique for the imaging and quantification of surface potentials which is based on the gating of a nanometer-size tip-attached quantum dot by the local surface potential and the detection of charge state changes via non-contact atomic force microscopy. Here, we present a rigorous formalism in the framework of which SQDM can be understood and interpreted quantitatively. In particular, we present a general theory of SQDM based on the classical boundary value problem of electrostatics, which is applicable to the full range of sample properties (conductive versus insulating, nanostructured versus homogeneously covered). We elaborate the general theory into a formalism suited for the quantitative analysis of images of nanostructured but predominantly flat and conductive samples.