bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maintenance of quality of life improvement for patients with chronic pain and obesity after interdisciplinary multimodal pain rehabilitation – A study using the Swedish Quality Registry for Pain Rehabilitation
Authors: Dong Huan‐Ji , Larsson Britt , Rivano Fischer Marcelo , Gerdle Björn 
Published: July 2019

AbstractBackgroundThroughout the world many people have both obesity and chronic pain, comorbidities that decrease Health‐Related Quality of Life (HRQoL). It is uncertain whether patients with comorbid obesity can maintain improved HRQoL after Interdisciplinary Multimodal Pain Rehabilitation (IMMPR).MethodsData from 2016, 2017, and 2018 were obtained from a national pain database for Swedish specialized pain clinics and collected at three time points: Pre‐IMMPR; Post‐ IMMPR; and 12‐month follow‐up (FU‐IMMPR). Participants (N = 872) reported body weight, height, pain aspects, and HRQoL (RAND 36‐Item Health Survey). Severe obesity (Body Mass Index, BMI ≥35 kg/m2) was defined according to WHO classifications. We used linear mixed regression models to examine BMI group differences in HRQoL over time.ResultsMore than 25% of patients (224/872) were obese and nearly 30% (63/224) of these were severely obese. All BMI groups improved significantly in both physical and mental composites of HRQoL after IMMPR (Pre‐ vs. Post‐IMMPR, p < .001). The improvements were maintained at a 12‐month follow‐up (Post‐ vs. FU‐IMMPR, p > .05). The severe obesity group had the lowest physical health score and least improvement (pre‐ vs. FU‐IMMPR, Cohen's d = o.422, small effect size). Severe obesity had negative impact on physical health (β = −4.39, p < .05) after controlling for sociodemographic factors and pain aspects.ConclusionImprovements in HRQoL after IMMPR were achieved and maintained across all weights, including patients with comorbid obesity. Only severe obesity was negatively associated with physical health aspects of HRQoL.SignificancePatients with chronic pain and comorbid obesity achieve sustained Health‐Related Quality of Life (HRQoL) improvements from Interdisciplinary Multimodal Pain Rehabilitation (IMMPR). This finding suggests that rehabilitation professionals should consider using IMMPR for patients with comorbid obesity even though their improvement may not reach the same level as for non‐obese patients.
An Electrochemical Sensor for the Detection of Cu2+ Based on Gold Nanoflowers‐modifed Electrode and DNAzyme Functionalized Au@MIL‐101 (Fe)
Authors: Xu Shengpan , Dai Benlin , Xu Jiming , Jiang Ling , Huang He 
Published: July 2019

AbstractIn this study, we developed an electrochemical sensor for sensitive detection of Cu2+ based on gold nanoflowers (AuNFs)‐modified electrode and DNAzyme functionalized Au@MIL‐101(Fe) (MIL: Materials of Institute Lavoisier). The AuNFs‐modified indium tin oxide modified conductive glass electrode(AuNFs/ITO) prepared via electrodeposition showed improved electronic transport properties and provided more active sites to adsorb large amounts of oligonucleotide substrate (DNA1) via thiol‐gold bonds. The stable Au@MIL‐101(Fe) could guarantee the sensitivity because of its intrinsic peroxidase mimic property, while the Cu2+‐dependent DNA‐cleaving DNAzyme linked to Au@MIL‐101(Fe) achieved the selectivity toward Cu2+. After the DNAzyme substrate strand (DNA2) was cleaved into two parts due to the presence of Cu2+, the oligonucleotide fragment linked to MIL‐101(Fe) was able to hybridize with DNA1 adsorbed onto the surface of AuNFs/ITO. Due to the peroxidase‐like catalytic activity of MIL‐101(Fe) and the affinity recognition property of DNAzyme toward Cu2+, the electrochemical biosensor showed a sensitive detection range from 0.001 to 100 μM, a detection limit of 0.457 nM and a high selectivity, demonstrating its potential for Cu2+ detection in real environmental samples.
Preparation and thermal properties of lauric acid/myristyl alcohol as a novel binary eutectic phase change material for indoor thermal comfort
Authors: Chinnasamy Veerakumar , Appukuttan Sreekumar 
Published: July 2019

AbstractThis work is about the preparation and studies on lauric acid‐ myristyl alcohol solid‐to‐liquid binary eutectic phase change material used for indoor thermal comfort. The binary eutectic mixture consisting of lauric acid (40%) and myristyl alcohol (60%) is prepared, and its thermal properties are investigated. From the differential scanning calorimetric results, it is evidenced that the developed phase change material (PCM) possesses a melting temperature and a latent heat of 21.3°C and 151.5 kJ kg−1, respectively. The freezing temperature and latent heat are 19.9°C and 151.6 kJ kg−1, respectively. The Fourier transform infrared (FT‐IR) spectroscopy results confirm that the eutectic PCM is chemically stable. The accelerated thermal cycling test proves that the developed eutectic PCM is thermally stable upto 1000 thermal cycles. The thermogravimetric results revealed that the degradation of developed eutectic PCM occurs at a temperature of 165°C, which is higher than the application temperature. Also, the results of corrosion test with the construction materials such as Cu, Al, and stainless steel are presented with necessary recommendations for using it in real‐time applications. The developed novel eutectic PCM has significant potential for using it in an indoor thermal comfort application.
Wetland Management Strategy to Reduce Mercury in Water and Bioaccumulation in Fish
Authors: Ackerman Joshua T. , Fleck Jacob A. , Eagles-Smith Collin A. , Marvin-DiPasquale Mark , Windham-Myers Lisamarie , Herzog Mark P. , McQuillen Harry L. 
Published: July 2019

Abstract
Wetland environments provide numerous ecosystem services but also facilitate methylmercury (MeHg) production and bioaccumulation. We developed a wetland-management technique to reduce MeHg concentrations in wetland fish and water. We physically modified seasonal wetlands by constructing open- and deep-water treatment cells at the downstream end of seasonal wetlands to promote naturally occurring MeHg-removal processes. We assessed the effectiveness of reducing mercury (Hg) concentrations in surface water and western mosquitofish that were caged at specific locations within 4 control and 4 treatment wetlands. Methylmercury concentrations in wetland water were successfully decreased within treatment cells during only the third year of study; however, treatment cells were not effective for reducing total Hg concentrations. Furthermore, treatment cells were not effective for reducing total Hg concentrations in wetland fish. Mercury concentrations in fish were not correlated with total Hg concentrations in filtered, particulate, or whole water; and the slope of the correlation with water MeHg concentrations differed between months. Fish total Hg concentrations were weakly correlated with water MeHg concentrations in April when fish were introduced into cages but were not correlated in May when fish were retrieved from cages. Fish total Hg concentrations were greater in treatment wetlands than in control wetlands the year after the treatment wetlands’ construction but declined by the second year. During the third year, fish total Hg concentrations increased in both control and treatment wetlands after an unexpected regional flooding event. Overall, we found limited support for the use of open- and deep-water treatment cells at the downstream end of wetlands to reduce MeHg concentrations in water but not fish. We suggest that additional evaluation over a longer period of time is necessary. Environ Toxicol Chem 2019;38:2178–2196. Published 2019 Wiley Periodicals, Inc. on behalf of SETAC. This article is a US government work, and as such, is in the public domain in the United States of America..
Abstract
We developed a wetland-management technique to reduce methylmercury concentrations in wetland fish and water. We physically modified seasonal wetlands by constructing open- and deep-water treatment cells at the downstream end of seasonal wetlands to promote naturally occurring methylmercury-removal processes.
DNA Double-Strand Breaks in Arctic Char (Salvelinus alpinus) from Bjørnøya in the Norwegian Arctic
Authors: Neerland Eirik D. , Bytingsvik Jenny , Nikiforov Vladimir A. , Evenset Anita , Krøkje Åse 
Published: July 2019

Abstract
High levels of organochlorine contaminants (OCs) have been found in arctic char (Salvelinus alpinus) from Lake Ellasjøen, Bjørnøya (Norwegian Arctic). The aim of the present study was to investigate the potential genotoxic effect of environmental organochlorine contaminant exposure in arctic char from Ellasjøen compared with arctic char from the low-contaminated Lake Laksvatn nearby. Blood was analyzed using agarose gel electrophoresis and image data analysis to quantify the fraction of total DNA that migrated into the gel (DNA-FTM) as a relative measure of DNA double-strand breaks (DSBs). Analysis by GC-MS of muscle samples showed an average 43 times higher concentration of ΣOCs in arctic char from Ellasjøen (n = 18) compared with Laksvatn char (n = 21). Char from Lake Ellasjøen had a much higher frequency of DSBs, as measured by DNA-FTM, than char from Lake Laksvatn. Principal component analysis and multiple linear regressions show that there was a significant positive relationship between DSBs and levels of organochlorine contaminants in the char. In addition, DSBs were less frequent in reproductively mature char than in immature char. The results suggest that organochlorine contaminants are genotoxic to arctic char. Environ Toxicol Chem 2019;38:2405–2413. © 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC
Abstract
Higher concentrations of organochlorines were associated with more DNA double-strand breaks in arctic char (Salvelinus alpinus) from 2 lakes on Bjørnøya, Norwegian Arctic. Fewer DNA double-strand breaks were observed in fish closer to the end of the reproductive cycle (spawning).
The what and where of primate field research may be failing primate conservation
Authors: Bezanson Michelle , McNamara Allison 
Published: July 2019

AbstractWith approximately 30% of nonhuman primate species listed as critically endangered, the window of opportunity to conserve primates is closing fast. In this article, we focus on the degree to which publications in field primatology are biased in favor of particular taxa and field sites. We examined more than 29,000 peer‐reviewed articles and identified 876 field visits to 349 field sites. We found a highly clumped distribution by site and species. We also examined publication ethical statements and the extent to which they acknowledged local human communities (<5%). Due to a lack of consistency across publications, we provide recommendations for improving ethical statements and for evaluating research impact. Given the plight of primate biodiversity, these results suggest broader coverage of primate species and geographies, as well as more attention to the local human communities whose support is necessary if the intent is to have primate species in the wild in the 22nd century.
Earliest Carboniferous stromatolites from the Qianheishan Formation, Dashuigou section, northwestern China: Implications for microbial proliferation after the end‐Devonian mass extinction
Authors: Yao Le , Aretz Markus , Chen Jitao , Qi Yuping 
Published: July 2019

Earliest Carboniferous stromatolites were found in the Qianheishan (QHS) Formation in the Dashuigou section, Gansu Province, northwestern China. These stromatolites are exposed in a conglomerate‐dominated succession of about 22.5 m in thickness, which can be traced laterally for more than 200 m in outcrop. They consist mainly of micrite, peloids, oncoids, silt‐sized quartz grains, and sparry calcite with rare fine to coarse quartz grains and bioclasts. The occurrence of marine fossils (e.g., bryozoans) and fenestral structures in the stromatolites suggests that they developed in intertidal environments. Three types of stromatolite laminae were distinguished including micritic laminae, grain‐dominated mixed laminae, and micrite‐dominated mixed laminae. These laminae are separated by thin micritic crusts and form two lamination styles of repetitive lamination and alternating lamination. The development of grain‐rich and micrite‐rich laminae in the stromatolites implies that they were formed by the combination of microbial baffling, binding, and calcification. Facies analysis suggests that growth and demise of the stromatolites were controlled by relative sea‐level changes. They grew during a continuous relative sea‐level rise, indicated by variations in their thickness and morphology. Stromatolites change from thin‐bedded laminar forms in the lower part of the studied interval to medium‐bedded wavy‐laminar forms and thick‐bedded domal forms in the middle and upper parts, respectively. Their demise was triggered by dramatic relative sea‐level fall, evidenced from the sandstone facies overlying the stromatolite interval. The occurrence of the QHS stromatolites provides an excellent example for microbial proliferation and profound changes in the marine biosphere after the end‐Devonian Hangenberg extinction event.
TOWARDS MORE EFFECTIVE IRRIGATION WATER USAGE BY EMPLOYING LAND SUITABILITY ASSESSMENT FOR VARIOUS IRRIGATION TECHNIQUES
Authors: Miháliková Markéta , Dengiz Orhan 
Published: July 2019

AbstractImprovement of agricultural water management by implementing more efficient irrigation methods is essential for sustainable use of water and soil resources. The main objective was to assess and compare the use of parametric evaluation (PM) and multi‐criteria assessment (MCA) in the decision and planning process of irrigation management by land suitability assessment of three irrigation techniques. Land and soil properties were determined and assessed, and suitability maps were produced for surface, sprinkler and drip irrigation methods in the Çarşamba Delta plain (Black Sea region, Turkey; 972.2 ha). MCA was more flexible and sensitive due to the analytical hierarchy process and thus better reflected real conditions, than the widely used PM. In both approaches, drip irrigation was the most suitable. The main restricting factors in all irrigation systems in this area were slope, soil depth and soil texture. Results demonstrated that the arability of 33% (PM) or 30% (MCA) of the study area would be improved by employing drip irrigation instead of surface or sprinkler irrigation. Maps show where the change of traditional surface irrigation system should start. Such a change would be projected into better water use efficiency and more efficient use of soil while reducing degradation processes, namely soil erosion. © 2019 John Wiley & Sons, Ltd.
MuRF1 and MuRF2 are key players in skeletal muscle regeneration involving myogenic deficit and deregulation of the chromatin‐remodeling complex
Authors: Moriscot Anselmo Sigari , Baptista Igor Luchini , Silva William José , Silvestre João Guilherme , Adams Volker , Gasch Alexander , Bogomolovas Julius , Labeit Siegfried 
Published: July 2019

AbstractBackgroundSkeletal muscle regeneration is a powerful and highly synchronized process and it is well described that intracellular pathways related to anabolic responses are readily activated. On the other hand, the role of catabolic pathways in the skeletal muscle regenerative response is much less understood. In the present study, we hypothesized that MuRF1, a key gene involved in skeletal muscle mass loss, and its close counterpart MuRF2 play a role in skeletal muscle regeneration.Methods and resultsWild type, single MuRF1 knock out, single MuRF2 knock out and double MuRF1&2 dKO mice had their tibialis anterior muscle injured by a single round of 4 sequential injections of cardiotoxin (CTX‐10ūM, 5ūl each injection) spread along the length of the muscle. The animals were killed after 1, 3, 10 and 28 days after injury and the muscles were used to address general histology, satellite cells, myogenic markers and apoptosis. In addition, we silenced MuRF1 and MuRF2 in a primary myogenic cell culture to evaluate myogenesis and BAF57, a SWI/SNF chromatin‐remodeling complex component. Finally, we employed Chromatin Immuno Precipitation assays to investigate whether MuRF1 associates with the myogenic promoters MyoD and myogenin. After cardiotoxin (CTX) injection, MuRF1 and MuRF2 expression was strongly increased and spread out inside the remaining fibers and also along satellite cells. In line with a critical role during regeneration, MuRF1&2 dKO deficient injured muscles were unable to properly regenerate. In addition, dKO injured muscle failed to express activators of the myogenic program, Myf‐5, FHL2 and MARP2, while myogenin levels were normally increased. Accordingly, siRNA reduced levels of MuRF1 and MuRF2 caused a severe myogenic deficit in primary myogenic cells, without any proliferation deficiency. Finally, in MuRF1&2 siRNA knockdown studies and Chromatin Immuno Precipitation analysis of primary myogenic cultures we have shown an impaired nuclear clearance of BAF57 and a shortage in chromatin remodeling as a likely mechanism underlying the deficient myogenic differentiation.ConclusionIn summary, our results indicate a key cooperative role of the E3 ligases MuRF1 and MuRF2 in skeletal muscle regenerative response and myogenesis by inducing chromatin opening at myogenic promoters after BAF57 removal during muscle regeneration.
Shedding light on fibered confocal fluorescence microscopy: Applications in biomedical imaging and therapies
Authors: Al‐Gubory Kaïs H. 
Published: July 2019

AbstractDiscoveries of major importance in life sciences and preclinical research are linked to the invention of microscopes that enable imaging of cells and their microstructures. Imaging technologies involving in vivo procedures using fluorescent dyes that permit labelling of cells have been developed over the last two decades. Fibered confocal fluorescence microscopy (FCFM) is an imaging technology equipped with fiber‐optic probes to deliver light to organs and tissues of live animals. This enables not only in vivo detection of fluorescent signals and visualization of cells, but also the study of dynamic processes, such cell proliferation, apoptosis and angiogenesis, under physiological and pathological conditions. This will allow the diagnosis of diseased organs and tissues and the evaluation of the efficacy of new therapies in animal models of human diseases. The aim of this report is to shed light on FCFM and its potential medical applications and discusses some factors that compromise the reliability and reproducibility of monitoring biological processes by FCFM. This report also highlights the issues concerning animal experimentation and welfare, and the contributions of FCFM to the 3Rs principals, replacement, reduction and refinement.
Associations between quantitative evaluation of bowel wall microvascular flow by contrast‐enhanced ultrasound and indices of disease activity in Crohn's disease patients using both bolus and infusion techniques
Authors: Zezos Petros , Zittan Eran , Islam Shadman , Hudson John , Ben‐Bassat Ofer , Nazarian Amin , Steinhart Hillary A. , Silverberg Mark S. , Atri Mostafa 
Published: July 2019

AbstractPurposeThe aim is to investigate whether baseline contrast‐enhanced ultrasound (CEUS) correlates with indices of activity in Crohn's disease (CD) and can predict response to medical treatment.MethodsIn this prospective study, symptomatic CD patients underwent baseline CEUS performed with Definity using both bolus and infusion methods. Time‐intensity curves (TIC), peak intensity (PI), and area under curve (AUC) from a region of interest over the diseased bowel were calculated for both bolus and infusion acquisitions. We used Mann‐Whitney U test for continuous and chi‐square/two‐tailed Fisher's exact test for categorical variable comparison and Spearman's correlation coefficient to correlate clinical score and CEUS kinetic parameters.ResultsTwenty‐one patients (9 men, 12 women, median age 32 years) were accrued. Fifteen patients had clinically active disease defined as Harvey‐Bradshaw Index (HBI) score ≥5. Median values of baseline CEUS parameters PI (bolus: 26 vs 8.86; P = .023 and perfusion: 7.6 vs 3.2; P = .009) and AUC (bolus: 769 vs 248.8; P = .036 and perfusion: 188.9 vs 73.9; P = .012) differed significantly in patients with active vs inactive disease. Nine patients with active disease underwent escalated or new treatment. Five were nonresponders. Responders had higher median values of baseline parameters (PI, bolus: 35 vs 18.8; P = .556, and perfusion: 7.6 vs 3.9; P = 190), (AUC, bolus: 1473.9 vs 314; P = .111, and perfusion: 154.7 vs 74.4, P = .286).ConclusionsCEUS kinetic parameters correlate with clinical and laboratory indices and are significantly higher in patients with active disease. The responders had higher CEUS kinetic parameters than nonresponders that did not reach statistical significance in our small cohort.
Light microscopy and scanning electron microscopy: Implications for authentication of misidentified herbal drugs
Authors: Zafar Muhammad , Ahmad Mushtaq , Sultana Shazia , Lubna  , Anjum Farida , Ozdemir Fethi Ahmet , Tariq Akash , Nazir Abdul , Yaseen Ghulam , Aabidin Sheikh Zain Ul , Gul Hina , Rehman Shafiq ur 
Published: July 2019

AbstractPlant‐based drugs have reached remarkable acceptability as therapeutic remedy for various diseases due to the adverse effects of contemporary medicines. This increasing popularity of herbal drugs leads to a growing herbal market for the development of plant‐based drugs, nutraceuticals, pharmaceuticals and cosmeceuticals. Herbal drug adulteration is a complex problem which currently has undeniable consequences on health and nutrition. Ambiguities in nomenclature, misidentification and resemblance of colour and texture of the crude herbal drugs are the major causes of adulteration. Three different species commercially marketed under the same trade name Halion are Lepidium apetalum, Asparagus officinalis, and Lepidium didymum. The genuine source of Halion is Lepidium apetalum, which is authenticated by using basic and advanced taxonomic techniques. Morphology, anatomy and palynology of the misidentified sources were done using light and scanning electron microscopic techniques for authentication. This study may help to set microscopic techniques as a tool to achieve quality and standardization of the genuine source of the herbal drug. Phytochemical analysis and biological screening is needed for the further establishment of authenticity and quality of herbal drugs.
High‐resolution bathymetric mapping reveals subaqueous glacial landforms in the Arctic alpine lake Tarfala, Sweden
Authors: Kirchner Nina , Noormets Riko , Kuttenkeuler Jakob , Erstorp Elias Strandell , Holmlund Erik Schytt , Rosqvist Gunhild , Holmlund Per , Wennbom Marika , Karlin Torbjörn 
Published: July 2019

ABSTRACTIn Arctic alpine regions, glacio‐lacustrine environments respond sensitively to variations in climate conditions, impacting, for example,glacier extent and rendering former ice‐contact lakes into ice distal lakes and vice versa. Lakefloors may hold morphological records of past glacier extent, but remoteness and long periods of ice cover on such lakes make acquisition of high‐resolution bathymetric datasets challenging. Lake Tarfala and Kebnepakte Glacier, located in the Kebnekaise mountains, northern Sweden, comprise a small, dynamic glacio‐lacustrine system holding a climate archive that is not well studied. Using an autonomous surface vessel, a high‐resolution bathymetric dataset for Lake Tarfala was acquired in 2016, from which previously undiscovered end moraines and a potential grounding line feature were identified. For Kebnepakte Glacier, structure‐from‐motion photogrammetry was used to reconstruct its shape from photographs taken in 1910 and 1945. Combining these methods connects the glacial landform record identified at the lakefloor with the centennial‐scale dynamic behaviour of Kebnepakte Glacier. During its maximum 20th century extent, attained c. 1910, Kebnepakte Glacier reached far into Lake Tarfala, but had retreated onto land by 1945, at an average of 7.9 m year–1. Copyright © 2019 John Wiley & Sons, Ltd.