bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergence of Delafloxacin-Resistant Staphylococcus aureus in Brooklyn, New York
Authors: Iregui Alejandro , Khan Zeb , Malik Saquib , Landman David , Quale John 
Published: August 2019

Abstract
Delafloxacin is an option for infections due to methicillin-resistant Staphylococcus aureus. In 2017, 22% of isolates from 7 hospitals in Brooklyn, New York, were nonsusceptible to delafloxacin. Isolates belonging to ST105, a strain associated with healthcare-related infections, predominated. Resistance was also found in ST8, a strain (USA300) associated with community-associated infections.
Monotone Lagrangians in Flag Varieties
Authors: Cho Yunhyung , Kim Yoosik 
Published: August 2019

AbstractIn this paper, we give a formula for the Maslov index of a gradient holomorphic disk, which is a relative version of the Chern number formula of a gradient holomorphic sphere for a Hamiltonian $S^1$-action. Using the formula, we classify all monotone Lagrangian fibers of Gelfand–Cetlin systems on partial flag manifolds.
Detection of atypical porcine pestivirus genome in newborn piglets affected by congenital tremor and high preweaning mortality1
Authors: Sutton Kylee M , Lahmers Kevin K , Harris Seth P , Wijesena Hiruni R , Mote Benny E , Kachman Stephen D , Borza Tudor , Ciobanu Daniel C 
Published: August 2019

Abstract
Recently, piglets from a high-health status farm began exhibiting congenital tremors, high preweaning mortality and incidence of splayed legs. Postmortem histological examination identified a small number of scattered white matter vacuoles in the cerebellum and underlying brainstem of affected piglets. Presence of potential viral sources associated with this neurologic condition was initially infirmed using quantitative PCR for atypical porcine pestivirus (APPV), porcine teschovirus, and porcine sapelovirus. Using metagenomic analysis, APPV was identified as the main microbial species in serum obtained from piglets affected by congenital tremor. These piglets had higher preweaning mortality rates (46.4% vs. 15.3%) and incidence of splayed legs (33.0% vs. 0.8 %) compared to unaffected piglets. Piglets affected by congenital tremor had higher viral titer (P &lt; 0.15) and larger birth weights (P &lt; 0.05) compared to normal litter mates. Whole-genome sequencing and genome assembly of the novel APPV strain (MK728876) was carried out using Oxford Nanopore and related bioinformatics pipelines. Phylogenic analysis demonstrated that this strain along with other completely sequenced APPV strains were grouped into 2 clades, both including strains-inducing congenital tremor. Strains appear to cluster based on region but there were still significant differences within regions. Future research needs to address potential underdiagnosis due to genetic diversity but also to understand mode of transmission, variation in virulence, and the role of host genetics in APPV susceptibility.
Identification and Characterization of Tumor-Initiating Cells in Multiple Myeloma
Authors: Gao Minjie , Bai Hua , Jethava Yogesh , Wu Yujie , Zhu Yuqi , Yang Ye , Xia Jiliang , Cao Huojun , Franqui-Machin Reinaldo , Nadiminti Kalyan , Thomas Gregory S , Salama Mohamed E , Altevogt Peter , Bishop Gail , Tomasson Michael , Janz Siegfried , Shi Jumei , Chen Lijuan , Frech Ivana , Tricot Guido , Zhan Fenghuang 
Published: August 2019

Abstract

Background
Treatment failures in cancers, including multiple myeloma (MM), are most likely due to the persistence of a minor population of tumor-initiating cells (TICs), which are noncycling or slowly cycling and very drug resistant.

Methods
Gene expression profiling and real-time quantitative reverse transcription polymerase chain reaction were employed to define genes differentially expressed between the side-population cells, which contain the TICs, and the main population of MM cells derived from 11 MM patient samples. Self-renewal potential was analyzed by clonogenicity and drug resistance of CD24+ MM cells. Flow cytometry (n = 60) and immunofluorescence (n = 66) were applied on MM patient samples to determine CD24 expression. Therapeutic effects of CD24 antibodies were tested in xenograft MM mouse models containing three to six mice per group.

Results
CD24 was highly expressed in the side-population cells, and CD24+ MM cells exhibited high expression of induced pluripotent or embryonic stem cell genes. CD24+ MM cells showed increased clonogenicity, drug resistance, and tumorigenicity. Only 10 CD24+ MM cells were required to develop plasmacytomas in mice (n = three of five mice after 27 days). The frequency of CD24+ MM cells was highly variable in primary MM samples, but the average of CD24+ MM cells was 8.3% after chemotherapy and in complete-remission MM samples with persistent minimal residual disease compared with 1.0% CD24+ MM cells in newly diagnosed MM samples (n = 26). MM patients with a high initial percentage of CD24+ MM cells had inferior progression-free survival (hazard ratio [HR] = 3.81, 95% confidence interval [CI] = 5.66 to 18.34, P &lt; .001) and overall survival (HR = 3.87, 95% CI = 16.61 to 34.39, P = .002). A CD24 antibody inhibited MM cell growth and prevented tumor progression in vivo.

Conclusion
Our studies demonstrate that CD24+ MM cells maintain the TIC features of self-renewal and drug resistance and provide a target for myeloma therapy.
Structural Inequality in Refugee Participation in Higher Education
Authors: Naylor Ryan , Terry Les , Rizzo Alberto , Nguyen Nga , Mifsud Nathan 
Published: August 2019

AbstractStructural inequality is a framework that examines conditions in which groups of people experience unequal opportunities in terms of roles, rights and decision-making compared to others. This research sought to examine whether students from refugee backgrounds faced structural inequalities in their access to higher education. Data regarding the participation of refugee students in higher education between 2011 and 2014 was obtained from the Australian Department of Education and Training. This data was compared with sector averages and those of students from formal equity backgrounds to establish possible structural impediments to university study. Students from refugee backgrounds were found to face both horizontal and vertical inequalities in their access to higher education, as do other equity groups. The experience of refugee students appears to have unique features, however, including gender, age, type of institution accessed and potentially field of study. These barriers may be addressed to some extent by university outreach and support programmes, but more will be required to facilitate full participation in higher education by these students.
Factors affecting canine fecal and parasitic contamination of public green spaces of Buenos Aires city, Argentina, and visitors’ perception of such contamination
Authors: Rubel Diana , Nemirovsky Sergio I , Gorosito Irene , Servián Andrea , Garbossa Graciela 
Published: August 2019

AbstractCanine fecal contamination in public green areas is difficult to control. Our objectives were to assess: (i) the relationship between fecal contamination in public green spaces of Buenos Aires (Argentina) and the type of green space (boulevard/square/park), considering their area, presence/absence of control measures, and human population density in the surroundings (high or low); (ii) the perception of people of such contamination and (iii) the frequency of parasites in dog feces. In each green space (n = 26), feces were counted in thirty 25-m2 plots randomly located. The opinion survey consisted of asking people (358) what their perception of fecal contamination was, whether it bothered them and whether they thought it was hazardous to the dogs’ or people’ health. Canine fecal samples randomly collected (n = 112) were concentrated and examined microscopically. Mixed-effect generalized linear models were fitted to evaluate the effect of selected variables on fecal contamination. People’s perception of human and canine health risks were assessed by logistic regression. Canine fecal contamination was lower in squares with control measures and in parks with control measures located in densely populated areas, and higher in boulevards located in densely populated areas. The visitor’s perception was that feces were associated with dirtiness (77%) and odor (30.8%). Parasites were detected in 51.8% of fecal samples. Our results confirm that environmental control measures decrease canine fecal contamination of public green spaces, and that more than 65% of the people interviewed do not relate fecal contamination to risks to human/dog health.
A young galaxy cluster in the old Universe
Authors: Hashimoto Tetsuya , Goto Tomotsugu , Momose Rieko , Ho Chien-Chang , Makiya Ryu , Chiang Chia-Ying , Kim Seong Jin 
Published: August 2019

ABSTRACT
Galaxies evolve from a blue star-forming phase into a red quiescent one by quenching their star formation activity. In high-density environments, this galaxy evolution proceeds earlier and more efficiently. Therefore, local galaxy clusters are dominated by well-evolved red elliptical galaxies. The fraction of blue galaxies in clusters monotonically declines with decreasing redshift, i.e. the Butcher–Oemler effect. In the local Universe, observed blue fractions of massive clusters are as small as ≲0.2. Here we report a discovery of a ‘blue cluster’ that is a local galaxy cluster with an unprecedentedly high fraction of blue star-forming galaxies yet hosted by a massive dark matter halo. The blue fraction is 0.57, which is 4.0σ higher than those of the other comparison clusters under the same selection and identification criteria. The velocity dispersion of the member galaxies is 510 km s−1, which corresponds to a dark matter halo mass of 2.0$^{+1.9}_{-1.0}\times 10^{14}$ M⊙. The blue fraction of the cluster is more than 4.7σ beyond the standard theoretical predictions including semi-analytic models of galaxy formation. The probability to find such a high blue fraction in an individual cluster is only 0.003 per cent, which challenges the current standard frameworks of the galaxy formation and evolution in the ΛCDM universe. The spatial distribution of galaxies around the blue cluster suggests that filamentary cold gas streams can exist in massive haloes even in the local Universe. However these cold streams have already disappeared in the theoretically simulated local universes.
Spatial and velocity offsets of Galactic masers from the centres of spiral arms
Authors: Vallée Jacques P 
Published: August 2019

ABSTRACT
Some theories about the spiral arms of galaxies predict an offset between different tracers of star formation. Our goal in this paper is to find such an offset between the observed locations of radio masers and the locations of the arms, using a recent four-arm model fitted to the CO 1–0 gas. Our method is to compare a recent global four-arm spiral model (as fitted to the arms’ tangents in the observed broad CO 1–0 gas) with the recent results for the trigonometric distances of radio masers, for the main arms (Cygnus–Norma, Perseus, Sagittarius–Carina, Scutum and Norma). Our results indicate that most radio masers are near the inner edge of each spiral arm (towards the Galactic Centre). These masers are offset from the model arm (where the broad CO 1–0 molecular region resides), by 0.34 ± 0.06 kpc inward. In radial velocity space, the median offset between masers and the CO-fitted model is around 10 ± 1 km s–1. Based on the fact that the masers are observed here to be radially inward of the broad CO gas in the Cygnus arm at 15 kpc along the Galactic meridian, the corotation radius of the Milky Way disc is >15 kpc distant from the Galactic Centre and the density wave’s angular pattern speed is <15 km s–1 kpc–1. The pitch angle of the arm should be measured using many arm tracers, and located on both sides of the Galactic meridian, to ensure better precision and to avoid a bias pertinent to a single tracer.
Time-slicing spiral galaxies with SDSS-IV MaNGA
Authors: Peterken Thomas , Fraser-McKelvie Amelia , Aragón-Salamanca Alfonso , Merrifield Michael , Kraljic Katarina , Knapen Johan H , Riffel Rogério , Brownstein Joel , Drory Niv 
Published: August 2019

ABSTRACT
Spectra of galaxies contain a wealth of information about the stellar populations from which they are made. With integral field unit (IFU) surveys, such data can be used to map out stellar population properties across the face of a galaxy, allowing one to go beyond simple radial profiles and study details of non-axisymmetric structure. To-date, however, such studies have been limited by the quality of available data and the power of spectral analysis tools. We now take the next step and study the barred spiral galaxy MCG + 07-28-064 from observations obtained as part of the SDSS-IV MaNGA project. We find that we can decompose this galaxy into ‘time slices,’ which reveal the varying contributions that stars of differing ages make to its bar and spiral structure, offering new insight into the evolution of these features. We find evidence for the ongoing growth of the bar, including the most recent star formation on its leading edge, and for the underlying density wave responsible for spiral structure. This pilot study indicates that there is a wealth of untapped information on the spatial distribution of star formation histories available in the current generation of IFU galaxy surveys.
Integral field spectroscopy of Green Peas – I. Disentangling disc-like turbulence and strong outflow kinematics in SDSS J083843.63+385350.5
Authors: Bosch G , Hägele G F , Amorín R , Firpo V , Cardaci M V , Vílchez J M , Pérez-Montero E , Papaderos P , Dors O L , Krabbe A C , Campuzano-Castro F 
Published: August 2019

ABSTRACT
Integral field spectroscopy is well known for providing detailed insight of extended sources thanks to the possibility of handling space resolved spectroscopic information. Simple and straightforward analysis such as single line fitting yields interesting results, although it might miss a more complete picture in many cases. Violent star-forming regions, such as starburst galaxies, display very complex emission line profiles due to multiple kinematic components superposed in the line of sight. We perform a spatially resolved kinematical study of a single Green Pea (GP) galaxy, SDSS J083843.63+385350.5, using a new method for analysing integral field unit observations of emission line spectra. The method considers the presence of multiple components in the emission line profiles and makes use of a statistical indicator to determine the meaningful number of components to fit the observed profiles. We are able to identify three distinct kinematic features throughout the field and discuss their link with a rotating component, a strong outflow, and a turbulent mixing layer. We also derive an updated star formation rate for SDSS J0838 and discuss the link between the observed signatures of a large-scale outflow and of the Lyman continuum leakage detected in GP galaxies.
Dark-age reionization and galaxy formation simulation – XIX. Predictions of infrared excess and cosmic star formation rate density from UV observations
Authors: Qiu Yisheng , Mutch Simon J , da Cunha Elisabete , Poole Gregory B , Wyithe J Stuart B 
Published: August 2019

ABSTRACT
We present a new analysis of high-redshift UV observations using a semi-analytic galaxy formation model, and provide self-consistent predictions of the infrared excess (IRX)–β relations and cosmic star formation rate density. We combine the Charlot & Fall dust attenuation model with the meraxes semi-analytic model, and explore three different parametrizations for the dust optical depths, linked to star formation rate, dust-to-gas ratio, and gas column density, respectively. A Bayesian approach is employed to statistically calibrate model-free parameters including star formation efficiency, mass loading factor, dust optical depths, and reddening slope directly against UV luminosity functions and colour–magnitude relations at $z$ ∼ 4–7. The best-fitting models show excellent agreement with the observations. We calculate IRX using energy balance arguments and find that the large intrinsic scatter in the IRX–β plane correlates with specific star formation rate. Additionally, the difference among the three dust models suggests at least a factor of 2 systematic uncertainty in the dust-corrected star formation rate when using the Meurer IRX–β relation at $z$ ≳ 4.
Slow and massive: low-spin SMBHs can grow more
Authors: Zubovas Kastytis , King Andrew 
Published: August 2019

Abstract
Active galactic nuclei (AGNs) probably control the growth of their host galaxies via feedback in the form of wide-angle wind-driven outflows. These establish the observed correlations between supermassive black hole (SMBH) masses and host galaxy properties, e.g. the spheroid velocity dispersion σ. In this paper we consider the growth of the SMBH once it starts driving a large-scale outflow through the galaxy. To clear the gas and ultimately terminate further growth of both the SMBH and the host galaxy, the black hole must continue to grow its mass significantly, by up to a factor of a few, after reaching this point. The mass increment ΔMBH depends sensitively on both galaxy size and SMBH spin. The galaxy size dependence leads to ΔMBH ∝ σ5 and a steepening of the M–σ relation beyond the analytically calculated M ∝ σ4, in agreement with observation. Slowly spinning black holes are much less efficient in producing feedback, so at any given σ the slowest spinning black holes should be the most massive. Current observational constraints are consistent with this picture, but insufficient to test it properly; however, this should change with upcoming surveys.
Star-forming, rotating spheroidal galaxies in the GAMA and SAMI surveys
Authors: Moffett Amanda J , Phillipps Steven , Robotham Aaron S G , Driver Simon P , Bremer Malcolm N , Cortese Luca , Wong O Ivy , Brough Sarah , Brown Michael J I , Bryant Julia J , Conselice Christopher J , Croom Scott M , George Koshy , Goldstein Greg , Goodwin Michael , Holwerda Benne W , Hopkins Andrew M , Konstantopoulos Iraklis S , Lawrence Jon S , Lorente Nuria P F , Medling Anne M , Owers Matt S , Pimbblet Kevin A , Richards Samuel N , Sweet Sarah M , van de Sande Jesse 
Published: August 2019

ABSTRACT
The Galaxy And Mass Assembly (GAMA) survey has morphologically identified a class of ‘Little Blue Spheroid’ (LBS) galaxies whose relationship to other classes of galaxies we now examine in detail. Considering a sample of 868 LBSs, we find that such galaxies display similar but not identical colours, specific star formation rates, stellar population ages, mass-to-light ratios, and metallicities to Sd-Irr galaxies. We also find that LBSs typically occupy environments of even lower density than those of Sd-Irr galaxies, where ∼65 per cent of LBS galaxies live in isolation. Using deep, high-resolution imaging from VST KiDS and the new Bayesian, 2D galaxy profile modelling code profit, we further examine the detailed structure of LBSs and find that their Sérsic indices, sizes, and axial ratios are compatible with those of low-mass elliptical galaxies. We then examine SAMI Galaxy survey integral field emission line kinematics for a subset of 62 LBSs and find that the majority (42) of these galaxies display ordered rotation with the remainder displaying disturbed/non-ordered dynamics. Finally, we consider potential evolutionary scenarios for a population with this unusual combination of properties, concluding that LBSs are likely formed by a mixture of merger and accretion processes still recently active in low-redshift dwarf populations. We also infer that if LBS-like galaxies were subjected to quenching in a rich environment, they would plausibly resemble cluster dwarf ellipticals.
Emission from the circumgalactic medium: from cosmological zoom-in simulations to multiwavelength observables
Authors: Augustin R , Quiret S , Milliard B , Péroux C , Vibert D , Blaizot J , Rasera Y , Teyssier R , Frank S , Deharveng J-M , Picouet V , Martin D C , Hamden E T , Thatte N , Pereira Santaella M , Routledge L , Zieleniewski S 
Published: August 2019

ABSTRACT
We simulate the flux emitted from galaxy haloes in order to quantify the brightness of the circumgalactic medium (CGM). We use dedicated zoom-in cosmological simulations with the hydrodynamical adaptive mesh refinement code ramses, which are evolved down to z = 0 and reach a maximum spatial resolution of 380 h−1 pc and a gas mass resolution up to $1.8\times 10^{5} \, h^{-1}\, \rm {M}_{\odot }$ in the densest regions. We compute the expected emission from the gas in the CGM using cloudy emissivity models for different lines (e.g. Lyα, C iv, O vi, C vi, O viii) considering UV background fluorescence, gravitational cooling and continuum emission. In the case of Lyα, we additionally consider the scattering of continuum photons. We compare our predictions to current observations and find them to be in good agreement at any redshift after adjusting the Lyα escape fraction. We combine our mock observations with instrument models for Faint Intergalactic Redshifted Emission Balloon-2 (FIREBall-2; UV balloon spectrograph) and HARMONI (visible and NIR IFU on the ELT) to predict CGM observations with either instrument and optimize target selections and observing strategies. Our results show that Lyα emission from the CGM at a redshift of 0.7 will be observable with FIREBall-2 for bright galaxies (NUV∼18 mag), while metal lines like O vi and C iv will remain challenging to detect. HARMONI is found to be well suited to study the CGM at different redshifts with various tracers.
A CO-multilayer outer atmosphere for eight evolved stars revealed with VLTI/AMBER
Authors: Hadjara M , Cruzalèbes P , Nitschelm C , Chen X , Michael E A , Moreno E 
Published: August 2019

Abstract
We determine the physical parameters of the outer atmosphere of a sample of eight evolved stars, including the red supergiant α Scorpii, the red giant branch stars α Bootis and γ Crucis, the K giant λ Velorum, the normal M giants BK Virginis and SW Virginis, and the Mira star W Hydrae (in two different luminosity phases) by spatially resolving the stars in the individual carbon monoxide (CO) first overtone lines. We used the Astronomical Multi-BEam combineR (AMBER) instrument at the Very Large Telescope Interferometer (VLTI), in high-resolution mode (λ/Δλ ≈ 12 000) between 2.28 and 2.31 $\, \mu {\rm m}$ in the K band. The maximal angular resolution is 10 mas, obtained using a triplet telescope configuration, with baselines from 7 to 48 m. By using a numerical model of a molecular atmosphere in a spherical shells (MOLsphere), called pampero (an acronym for the ‘physical approach of molecular photospheric ejection at high angular resolution for evolved stars’), we add multiple extended CO layers above the photospheric marcs model at an adequate spatial resolution. We use the differential visibilities and the spectrum to estimate the size (R) of the CO molsphere, its column density (NCO) and temperature (Tmol) distributions along the stellar radius. The combining of the χ2 minimization and a fine grid approach for uncertainty analysis leads to reasonable NCO and Tmol distributions along the stellar radius of the MOLsphere.