bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telecom photon interface of solid-state quantum nodes
Authors: Li Changhao , Cappellaro Paola 
Published: September 2019

Abstract
Solid-state spins such as nitrogen-vacancy (NV) center are promising platforms for large-scale quantum networks. Despite the optical interface of NV center system, however, the significant attenuation of its zero-phonon-line photon in optical fiber prevents the network extended to long distances. Therefore a telecom-wavelength photon interface would be essential to reduce the photon loss in transporting quantum information. Here we propose an efficient scheme for coupling telecom photon to NV center ensembles mediated by rare-earth doped crystal. Specifically, we proposed protocols for high fidelity quantum state transfer and entanglement generation with parameters within reach of current technologies. Such an interface would bring new insights into future implementations of long-range quantum network with NV centers in diamond acting as quantum nodes.
Exploiting asymmetric wire critical current for the reduction of AC loss in HTS coil windings
Authors: Jiang Zhenan , Endo Natsumi , Wimbush Stuart C , Brooks Justin , Song Wenjuan , Badcock Rodney A , Miyagi Daisuke , Tsuda Makoto 
Published: September 2019

Abstract
Critical current and AC loss in coil windings are two important factors for various HTS applications. Many coated conductors exhibit asymmetry in the variation of the critical current with magnetic field angle. This asymmetry results in different coil critical current values depending on the orientation of the conductors in the coil windings. We report critical current and AC loss results at 77 K and 65 K for three hybrid coil assemblies which have a common central winding and different arrangements of the end windings. We found a difference greater than 13% in both the critical current and the AC loss results for the different arrangements. The results imply that if we wind coil assemblies smartly even using the same materials and the same design, we can not only improve critical current but also reduce AC loss significantly.
Biaxial strain tuning of interlayer excitons in bilayer MoS2
Authors: Carrascoso Felix , Lin Der-Yuh , Frisenda Riccardo , Castellanos-Gomez Andres 
Published: September 2019

Abstract
We show how the excitonic features of biaxial MoS2 flakes are very sensitive to biaxial strain. We find a lower bound for the gauge factors of the A exciton and B exciton of (−41 ± 2) meV/% and (−45 ± 2) meV/% respectively, which are larger than those found for single-layer MoS2. Interestingly, the interlayer exciton feature also shifts upon biaxial strain but with a gauge factor that is systematically larger than that found for the A exciton, (−48 ± 4) meV/%. We attribute this larger gauge factor for the interlayer exciton to the strain tunable van der Waals interaction due to the Poisson effect (the interlayer distance changes upon biaxial strain).
Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group
Authors: Irvin Marguerite R , Sitlani Colleen M , Floyd James S , Psaty Bruce M , Bis Joshua C , Wiggins Kerri L , Whitsel Eric A , Sturmer Til , Stewart James , Raffield Laura , Sun Fangui , Liu Ching-Ti , Xu Hanfei , Cupples Adrienne L , Tanner Rikki M , Rossing Peter , Smith Albert , Zilhão Nuno R , Launer Lenore J , Noordam Raymond , Rotter Jerome I , Yao Jie , Li Xiaohui , Guo Xiuqing , Limdi Nita , Sundaresan Aishwarya , Lange Leslie , Correa Adolfo , Stott David J , Ford Ian , Jukema J Wouter , Gudnason Vilmundur , Mook-Kanamori Dennis O , Trompet Stella , Palmas Walter , Warren Helen R , Hellwege Jacklyn N , Giri Ayush , O'donnell Christopher , Hung Adriana M , Edwards Todd L , Ahluwalia Tarunveer S , Arnett Donna K , Avery Christy L 
Published: September 2019

Abstract

BACKGROUND
Only a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described.

METHODS
We conducted a case–control genome-wide association study of aTRH among persons treated for hypertension, using data from 10 cohorts of European ancestry (EA) and 5 cohorts of African ancestry (AA). Cases were treated with 3 different antihypertensive medication classes and had blood pressure (BP) above goal (systolic BP ≥ 140 mm Hg and/or diastolic BP ≥ 90 mm Hg) or 4 or more medication classes regardless of BP control (nEA = 931, nAA = 228). Both a normotensive control group and a treatment-responsive control group were considered in separate analyses. Normotensive controls were untreated (nEA = 14,210, nAA = 2,480) and had systolic BP/diastolic BP &lt; 140/90 mm Hg. Treatment-responsive controls (nEA = 5,266, nAA = 1,817) had BP at goal (&lt;140/90 mm Hg), while treated with one antihypertensive medication class. Individual cohorts used logistic regression with adjustment for age, sex, study site, and principal components for ancestry to examine the association of single-nucleotide polymorphisms with case–control status. Inverse variance-weighted fixed-effects meta-analyses were carried out using METAL.

RESULTS
The known hypertension locus, CASZ1, was a top finding among EAs (P = 1.1 × 10−8) and in the race-combined analysis (P = 1.5 × 10−9) using the normotensive control group (rs12046278, odds ratio = 0.71 (95% confidence interval: 0.6–0.8)). Single-nucleotide polymorphisms in this locus were robustly replicated in the Million Veterans Program (MVP) study in consideration of a treatment-responsive control group. There were no statistically significant findings for the discovery analyses including treatment-responsive controls.

CONCLUSION
This genomic discovery effort for aTRH identified CASZ1 as an aTRH risk locus.
Two Distinct Systems Represent Contralateral and Ipsilateral Sensorimotor Processes in the Human Premotor Cortex: A Dense TMS Mapping Study
Authors: Lega Carlotta , Chelazzi Leonardo , Cattaneo Luigi 
Published: September 2019

AbstractAnimal brains contain behaviorally committed representations of the surrounding world, which integrate sensory and motor information. In primates, sensorimotor mechanisms reside in part in the premotor cortex (PM), where sensorimotor neurons are topographically clustered according to functional specialization. Detailed functional cartography of the human PM is still under investigation. We explored the topographic distribution of spatially dependent sensorimotor functions in healthy volunteers performing left or right, hand or foot, responses to visual cues presented in the left or right hemispace, thus combining independently stimulus side, effector side, and effector type. Event-related transcranial magnetic stimulation was applied to single spots of a dense grid of 10 points on the participants’ left hemiscalp, covering the whole PM. Results showed: (1) spatially segregated hand and foot representations, (2) focal representations of contralateral cues and movements in the dorsal PM, and (3) distributed representations of ipsilateral cues and movements in the ventral and dorso-medial PM. The present novel causal information indicates that (1) the human PM is somatotopically organized and (2) the left PM contains sensory-motor representations of both hemispaces and of both hemibodies, but the hemispace and hemibody contralateral to the PM are mapped on a distinct, nonoverlapping cortical region compared to the ipsilateral ones.
The Emergence of “Universal Jurisdiction” in Response to Somali Piracy: An Empirically Informed Critique of International Law’s “Paradigmatic” Universal Jurisdiction Crime
Authors: Garrod Matthew 
Published: September 2019

Abstract
Since the 1980s, the idea that piracy is the “original” and “paradigmatic” universal jurisdiction crime in customary international law has been increasingly supported by weighty scholarship. In the wake of the unprecedented surge in Somali piracy, this view is gaining ground among various powerful actors in international law. Yet, remarkably little empirically grounded scholarship exists in support of universal jurisdiction. This Article provides the first comprehensive empirical analysis of state practice in response to Somali piracy in a ten-year period since 2006. Additionally, the data on Somali piracy are compared with the empirical findings of state practice regarding international crimes, which are more “heinous” than piracy, since the end of World War II to 2016. In so doing, this Article brings new insight and the first thorough critique of what most scholars, governments, the UN and even the International Court of Justice have said on universal jurisdiction, its purpose and the basis for it in international law. In view of inter-state tensions and conflict caused by universal jurisdiction and a move towards law codification, there is now a pressing need for a paradigm shift in the concept of universal jurisdiction for both piracy and international crimes, a step away from conventional scholarly accounts, and the grand narratives from which they proceed, to a position that has a solid basis in the actual practice of states. Empirically and historically informed, it is proposed that “universal jurisdiction” for both categories of crime provides a basis in international law permitting the exercise of national criminal jurisdiction over offences involving foreign nationals abroad that have a close nexus between the case over which jurisdiction is asserted and the state asserting jurisdiction. Common and traditionally held assumptions that universal jurisdiction is based solely on the grave nature of crimes and is applied by states absent any nexus to offences and in the interest of the international community are unfounded.
A (Zero-Knowledge) Vector Commitment with Sum Binding and its Applications
Authors: Wang Qiang , Zhou Fucai , Xu Jian , Xu Zifeng 
Published: September 2019

Abstract
Vector commitment (VC) schemes allow committing to an ordered sequence of ${q}$ values ${(m_1,\cdots ,m_q)}$ in such a way that one can later open the commitment at specific positions. However, the existing VC schemes suffer from two substantial shortcomings that limit their use: (i) the commitments cannot be opened except at some specific positions, and (ii) their security only captures position-binding but offers no privacy: the client may learn additional information about the committed sequence through the proofs and the commitments. To resolve these problems, we first extend VC to a more expressive primitive called VC with sum binding (VCS), in which the commitment can also be opened to the sum of all elements in the committed sequence. VCS additionally satisfies the security of sum binding, which guarantees that the commitment cannot be opened to different sums. To enhance its privacy, we extend VCS to zero-knowledge VCS (ZKVCS), in which commitments and proofs constructed during the protocol execution leak nothing about the committed sequence. We formalize this new property by a standard real/ideal experiment. Meanwhile, the detailed performance analyses and simulations show that our proposed schemes are more practical. Finally, we introduce a novel notion of (zero-knowledge) verifiable database supporting sum and show how to construct it from our (ZK)VCS scheme.
Understanding Pretend Emotions in Children Who Are Deaf and Hard of Hearing
Authors: Sidera Francesc , Morgan Gary , Serrat Elisabet 
Published: September 2019

Abstract
Children who are deaf and hard of hearing (DHH) and born to hearing parents have delays in their social-cognitive development and in particular in their theory of mind (ToM). These delays are often attributed to the difficulties they encounter in acquiring age-appropriate linguistic and communicative skills. The present study asks whether this developmental delay extends to problems with understanding pretend emotions and if linguistic difficulties are related to this area. A total of 173 children (82 DHH and 91 hearing) between 3 and 8 years of age received a set of emotion and language measures. Results showed that children who are DHH were delayed in understanding pretend emotions, and this was strongly related to their difficulties with expressive vocabulary and pragmatics. In summary, children who are DHH and have experienced reduced access to language and communicative interaction have a restricted understanding of the communicative intentions of emotional expressions. These delays may have implications for their social relationships with surrounding family and other children.
Genetics of Adaptation of the Ascomycetous Fungus Podospora anserina to Submerged Cultivation
Authors: Kudryavtseva Olga A , Safina Ksenia R , Vakhrusheva Olga A , Logacheva Maria D , Penin Aleksey A , Neretina Tatiana V , Moskalenko Viktoria N , Glagoleva Elena S , Bazykin Georgii A , Kondrashov Alexey S 
Published: September 2019

AbstractPodospora anserina is a model ascomycetous fungus which shows pronounced phenotypic senescence when grown on solid medium but possesses unlimited lifespan under submerged cultivation. In order to study the genetic aspects of adaptation of P. anserina to submerged cultivation, we initiated a long-term evolution experiment. In the course of the first 4 years of the experiment, 125 single-nucleotide substitutions and 23 short indels were fixed in eight independently evolving populations. Six proteins that affect fungal growth and development evolved in more than one population; in particular, in the G-protein alpha subunit FadA, new alleles fixed in seven out of eight experimental populations, and these fixations affected just four amino acid sites, which is an unprecedented level of parallelism in experimental evolution. Parallel evolution at the level of genes and pathways, an excess of nonsense and missense substitutions, and an elevated conservation of proteins and their sites where the changes occurred suggest that many of the observed fixations were adaptive and driven by positive selection.
Genome sequence of the Chinese white wax scale insect Ericerus pela: the first draft genome for the Coccidae family of scale insects
Authors: Yang Pu , Yu Shuhui , Hao Junjun , Liu Wei , Zhao Zunling , Zhu Zengrong , Sun Tao , Wang Xueqing , Song Qisheng 
Published: September 2019

AbstractBackgroundThe Chinese white wax scale insect, Ericerus pela, is best known for producing wax, which has been widely used in candle production, casting, Chinese medicine, and wax printing products for thousands of years. The secretion of wax, and other unusual features of scale insects, is thought to be an adaptation to their change from an ancestral ground-dwelling lifestyle to a sedentary lifestyle on the higher parts of plants. As well as helping to improve its economic value, studies of E. pela might also help to explain the adaptation of scale insects. However, no genomic data are currently available for E. pela.FindingsTo assemble the E. pela genome, 303.92 Gb of data were generated using Illumina and Pacific Biosciences sequencing, producing 277.22 Gb of clean data for assembly. The assembled genome size was 0.66 Gb, with 1,979 scaffolds and a scaffold N50 of 735 kb. The guanine + cytosine content was 33.80%. A total of 12,022 protein-coding genes were predicted, with a mean coding sequence length of 1,370 bp. Twenty-six fatty acyl-CoA reductase genes and 35 acyltransferase genes were identified. Evolutionary analysis revealed that E. pela and aphids formed a sister group and split ∼241.1 million years ago. There were 214 expanded gene families and 2,219 contracted gene families in E. pela.ConclusionWe present the first genome sequence from the Coccidae family. These results will help to increase our understanding of the evolution of unique features in scale insects, and provide important genetic information for further research.
The changing patterns of access overtime to the renal replacement therapy programme in Thailand
Authors: Thammatacharee Noppakun , Mills Anne , Nitsch Dorothea , Lumpaopong Adisorn 
Published: September 2019

AbstractBased on projected numbers, approximately only 50% of those requiring renal replacement therapy (RRT) receive it. Many patients who require RRT live in low- and middle-income countries. The objective of this study was to examine the changing pattern over time of entry into the RRT programme in Thailand following RRT’s inclusion in the Universal Coverage Scheme. This study was an ecological study using the age-period-cohort analysis to look at dialysis registration and kidney transplant trends during RRT programme implementation. Data from 2008 to 2016 of patients diagnosed with end-stage renal disease (ESRD) were obtained from the National Health Security Office. The study found that the numbers of new patients with ESRD, aged 20–69, registered with the dialysis programme increased over time. For patients aged 20–40 years, the dialysis programme took up to 400 new patients for every 1000 new ESRD diagnoses. For kidney transplant, the rates increased slowly. The kidney transplant programme could at best treat only around 50 cases for every 1000 new ESRD diagnoses in patients aged 20–30 years. Findings of this study highlighted the importance of promoting strategies to reduce the increasing number of patients with kidney disease, to consider conservative therapy for older/frail patients, and to improve access to kidney transplantation and live-donation.
A strategic tool to improve long-term health outcomes in clinical practice: SHOR driver and association diagram
Authors: Ogink Helena , Ringqvist Anna-Karin , Bergqvist Liselotte , Nordin Tobias , Nordenson Anita , Mårdby Ann-Charlotte 
Published: September 2019

Abstract

Quality problem or issue
An over-arching principle of healthcare governance in Sweden is to achieve as much health for as many patients as possible given the available resources. With high life expectancy and increased years lived with non-communicable diseases, more effective interventions in prevention and control of non-communicable diseases are needed in order to ensure high-quality healthcare.

Initial assessment
Few publications have described a generic and resource-effective method of implementing the perspective of health outcomes in relation to costs in a clinical Swedish university hospital context. To fill this gap, a generic method was developed at Sahlgrenska University hospital in Gothenburg, Sweden.

Choice of solution
A System-based driver and association diagram of Health Outcomes in relation to available Resources (SHOR) was developed. The SHOR driver and association diagram comprised different perspectives: health, patient, process, research and cost perspectives. It enabled the translation from long-term health outcomes to applications in clinical practice.

Implementation
Three patient groups exemplify the use and implementation of the method of SHOR association and driver diagram; bipolar disorder (psychiatry), primiparous women with spontaneous onset of labour, (obstetric care) and chronic obstructive pulmonary disease (somatic care).

Evaluation
The SHOR driver and association diagram enabled a structure to monitor and support quality development towards maximised health outcomes in relation to available resources and associated total costs for a specific patient group.

Lessons learned
This method has connected clinical practice, management and research and has been used for both strategic and operational purposes.
Bending the quality curve
Authors: Braithwaite Jeffrey , Clay-Williams Robyn , Taylor Natalie , Ting Hsuen P , Winata Teresa , Arnolda Gaston , Sunol Rosa , Gröne Oliver , Wagner Cordula , Klazinga Niek S , Donaldson Liam , Dowton S Bruce 
Published: September 2019

Abstract
With this paper, we initiate the Supplement on Deepening our Understanding of Quality in Australia (DUQuA). DUQuA is an at-scale, cross-sectional research programme examining the quality activities in 32 large hospitals across Australia. It is based on, with suitable modifications and extensions, the Deepening our Understanding of Quality improvement in Europe (DUQuE) research programme, also published as a Supplement in this Journal, in 2014. First, we briefly discuss key data about Australia, the health of its population and its health system. Then, to provide context for the work, we discuss previous activities on the quality of care and improvement leading up to the DUQuA studies. Next, we present a selection of key interventional studies and policy and institutional initiatives to date. Finally, we conclude by outlining, in brief, the aims and scope of the articles that follow in the Supplement. This first article acts as a framing vehicle for the DUQuA studies as a whole. Aggregated, the series of papers collectively attempts an answer to the questions: what is the relationship between quality strategies, both hospital-wide and at department level? and what are the relationships between the way care is organised, and the actual quality of care as delivered? Papers in the Supplement deal with a multiplicity of issues including: how the DUQuA investigators made progress over time, what the results mean in context, the scales designed or modified along the way for measuring the quality of care, methodological considerations and provision of lessons learnt for the benefit of future researchers.
Using accreditation surveyors to conduct health services research: a qualitative, comparative study in Australia
Authors: Winata Teresa , Clay-Williams Robyn , Taylor Natalie , Hogden Emily , Hibbert Peter , Austin Elizabeth , Braithwaite Jeffrey 
Published: September 2019

Abstract

Objective
Healthcare accreditation surveyors are well positioned to gain access to hospitals and apply their existing data collection skills to research. Consequently, we contracted and trained a surveyor cohort to collect research data for the Deepening our Understanding of Quality in Australia (DUQuA) project. The aim of this study is to explore and compare surveyors’ perceptions and experiences in collecting quality and safety data for accreditation and for health services research.

Design
A qualitative, comparative study.

Setting and Participants
Ten surveyors participated in semi-structured interviews, which were audio recorded, transcribed and coded using Nvivo11. Interview transcripts of participants were analysed thematically and separately, providing an opportunity for comparison and for identifying common themes and subthemes.

Intervention(s)
None.

Main Outcome Measure(s)
Topics addressed data collection for healthcare accreditation and research, including preparation and training, structure, organization, attitudes and behaviours of staff and perceptions of their role.

Results
Five themes and ten subthemes emerged from the interviews: (1) overlapping facilitators for accreditation and research data collection, (2) accreditation-specific facilitators, (3) overlapping barriers for accreditation and research data collection, (4) research data collection-specific barriers and (5) needs and recommendations. Subthemes were (1.1) preparation and training availability, (1.2) prior knowledge and experiences; (2.1) ease of access, (2.2) high staff engagement, (3.1) time, (4.1) poor access and structure, (4.2) lack of staff engagement, (4.3) organizational changes; (5.1) short-notice accreditation and (5.2) preparation for future research.

Conclusions
Although hospital accreditation and research activities require different approaches to data collection, we found that suitably trained accreditation surveyors were able to perform both activities effectively. The barriers surveyors encountered when collecting data for research provide insight into the challenges that may be faced when visiting hospitals for short-notice accreditation.