bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial and temporal modeling of the global burden of Cutaneous Leishmaniasis in Brazil: A 21-year ecological study
Authors: Reis Erica Santos dos , Paz Wandklebson Silva , Santos Ramos Rosália Elen , Nunes Ribeiro Caíque Jordan , Biano Laiza Santos , Bezerra-Santos Márcio , de Oliveira Camila Indiani , Lipscomb Michael Wheeler , de Moura Tatiana Rodrigues 
Published: November 2024

Background
Cutaneous Leishmaniasis (CL) is a neglected tropical disease endemic in Brazil. Morbidity and disabilities caused by CL lesions require an analysis of a Global Burden of Disease (GBD), which would help discern the impact on the Brazilian population. Herein, we assess the burden of CL and its spatial and temporal patterns in Brazil between 2001 and 2021.

Methodology/Principal findings
We estimated rates per 100,000 population for years lived with disabilities (YLD), years of life lost prematurely (YLL) and disability-adjusted life years (DALY) for each year of the study, sex assigned at birth, age group, and for each municipality in Brazil. In addition, the relative changes in these metrics over time for each region and sex were determined, as well as temporal trends using segmented joinpoint regression models. Using spatiotemporal analysis tools, we created choropleth maps representing DALY, YLD and YLL for three distinct periods (P1 = 2001 to 2007; P2 = 2008 to 2014; P3 = 2015 to 2021). These maps were constructed to visualize the inferences from Bayesian spatial statistics and Moran’s autocorrelation using the Poisson model. The data were obtained from the DATASUS database. Although the global burden of CL has reduced over two decades, with the continual high impact among adults aged 20 to 39 years. In turn, YLL increased over time in 40-year-old populations, while among the elderly (>60 years old) this rate almost doubled from 2010 to 2021. Regarding the region of residence, we observed an average increase of 28% in YLL in Southeast, South and Central-West. Furthermore, the global burden of CL does not have a random spatial distribution, since there was a high-risk clustering of YLD in the north of the country. Interestingly, the YLL showed a vast geographic expansion through Brazilian territory.

Conclusions
This study provides a comprehensive analysis of the burden of CL in Brazil, pointing out areas of highest disease burden, where control and surveillance efforts should be undertaken.
Healthcare providers’ pain management practice and its associated factors in Ethiopia: A systematic review and meta- analysis
Authors: Kefale Demewoz , Aytenew Tigabu Munye , Kassie Yohannes Tesfahun , Kebede Melese , Mekie Maru , Wondim Mahilet , Zeleke Shegaw , Demis Solomon , Baye Astewle Andargie , Bishaw Keralem Anteneh , Nibret Gedefaye , Eshetie Yeshiambaw , Muche Zelalem Tilahun , Shimels Habtamu , Chanie Muluken , Endalew Mastewal , Asferie Worku Necho , kassaw Amare 
Published: November 2024

Introduction
Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Under -treatment of pain continues to be a major health care problem in Ethiopia. Although it has this problem, it receives limited research attention. This systematic review and meta-analysis will provide valuable insights of prevalence and its factors of healthcare providers’ pain management practice in Ethiopia.

Methods
This systematic review and meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Universal online databases such as PubMed, Cochrane, Google, Google Scholar, SCOPUS, Web of Science and Global Health were used to search for articles. Microsoft Excel for data extraction and STATA17 for data analysis were used. DerSimonian and Laird random-effects model was used to pool the odds ratios across studies and compute the overall pooled prevalence and its predictors. Egger’s test with funnel plot symmetry and Cochrane’s Q test was used to assess publication bias and heterogeneity respectively.

Results
The overall pooled prevalence of health care providers’ pain management practice was 39.6% (95% CI: 34.8, 44.5); I2 = 97.0%; P<0.001). Availability of pain management protocol (AOR = 5.1, 95%CI: 3.6, 6.7), Accessibility of analgesia (AOR = 4.5, 95%CI: 1.96, 7.0), higher educational level (AOR = 3.3, 95%CI: 2.5, 4.1), being female (AOR = 1.2, 95% CI: 1.6, 3.1), took training (AOR = 2.7, 95% CI: 1.8, 3.6), decreased work load (AOR = 4.9, 95% CI: -1.9, 11.7), increased work experience (AOR = 3.9, 95% CI: 2.9, 5.1), Being midwifery profession (AOR = 2.5,95% CI: 1.6, 3.4), having good attitude (AOR = 3.9,95%CI: 2.5, 5.4) and being knowledgeable (AOR = 4.2, 95%CI: 2.8, 5.6) of health care providers towards pain management practice were significantly associated in Ethiopia.

Conclusion
The overall prevalence of pain management practice among healthcare providers in Ethiopia is low compared with a national target of pain free hospital initiatives in Ethiopia. It needs a call to build health care providers’ ongoing education, training, professional development and manageable workload.
Time-Series analysis of short-term exposure to air pollutants and daily hospital admissions for stroke in Tabriz, Iran
Authors: Razzaghi Shahryar , Mousavi Saeid , Jaberinezhad Mehran , Farshbaf Khalili Ali , Banan Khojasteh Seyed Mahdi 
Published: November 2024

Background
Air pollution is considered one of the risk factors for stroke prevalence in the long term and incidence in the short term. Tabriz is one of the most important industrial cities in Iran. Hence, air pollution has always been one of the main concerns in environmental health in the region.

Method
The patient data were retrieved from electronic health records of the primary tertiary hospital of the city (Imam Reza Hospital). Air pollution data was obtained from the Environmental Protection Agency and is generated by 8 sensor stations spread across the city. Average daily values were calculated for CO, NO, NO, NOx, O3, SO2, PM2.5, and PM10 from hourly measurement data. Autoregressive integrated moving average (ARIMA-X) model with 3 lag days was developed to assess the correlation.

Results
Air pollutants and hospital admission data were collected for 1821 day and includes 4865 stroke cases. our analysis showed no statistically significant association between the daily concentrations of CO (p = 0.41), NOx (p = 0.96), O3 (p = 0.65), SO2 (p = 0.91), PM2.5 (p = 0.44), and PM10 (p = 0.36). Only the binary COVID variable which was used to distinguish between COVID-19 era and other days, was significant (p value = 0.042). The goodness of fit measures, Root Mean Squared Error (RMSE), and Median Absolute Error (MAE) were 1.81 and 1.19, respectively.

Conclusion
In contrast to previous reports on the subject, we did not find any pollutant significantly associated with an increased number of stroke patients.
Association of intra-articular injection and knee arthroscopy prior to primary knee replacement with the timing and outcomes of surgery: Retrospective cohort study using data from the Clinical Practice Research Datalink GOLD database
Authors: Strang Matthew , Broomfield John , Whitehouse Michael , Kunutsor Setor , Glyn-Jones Sion , Delmestri Antonella , Blom Ashley , Judge Andrew 
Published: November 2024

Background
Patients with symptomatic knee osteoarthritis may undergo non-surgical interventions such as intra-articular steroid injections and knee arthroscopy. This study aimed to investigate their association with the timing and outcomes of subsequent primary knee replacement.

Methods and findings
Observational retrospective analysis of linked Clinical Practice Research Datalink, Hospital Episode Statistics, Patient Reported Outcome Measures (CPRD GOLD-HES-PROMS) data of 38,494 patients undergoing primary knee replacements in England. Prior use of intra-articular steroid injections and knee arthroscopy were identified. Hazard ratios (HRs) with 95% CIs were estimated for primary outcomes of revision and reoperation using Cox regression. Secondary outcomes included time from first diagnosis of ipsilateral knee osteoarthritis to knee replacement, 6-month post-operative Oxford Knee Scores (OKS), mortality (90-days and 3-months), and post-operative surgical site infection (SSI) (3-months) using linear and logistic regression. Prior steroid injections were associated with an increased risk of revision (HR = 1.25 95%CI (1.06 to 1.49)), re-operation (HR = 1.18 95%CI (1.05 to 1.32)), and SSI (HR = 3.10 95%CI (1.14 to 8.46). Timing from diagnosis of knee osteoarthritis to knee replacement was 6 months longer in patients receiving steroid injections. Knee arthroscopy was associated with an increased risk of revision (HR = 3.14 95%CI (2.64 to 3.73)), re-operation (HR = 3.25 95%CI (2.89 to 3.66)), lower post-operative OKS -1.63 95%CI (-2.31 to -0.95). Both interventions were associated with a lower risk of mortality.

Conclusions
Steroid injection and knee arthroscopy prior to primary knee replacement are each associated with worse outcomes. The observed association of lower mortality risk is suggestive of confounding by indication. The observed associations in this study could be used to inform shared decision making with patients on the treatment pathway for knee osteoarthritis.
Design of a Point of Sales and Membership Integration Model at Campus Business Unit in Politeknik Negeri Manado
Authors: Paendong Melky , Kumaat Arief Perdana , Mandulangi Jufrina , Artana I Made Wahyu 
Published: November 2024

Campus business units have great potential to become innovative business laboratories. By adopting advanced information technology, campus business units can develop unique business models that are relevant to market needs. Therefore, there is a need for innovation and business strategies that enable to compete with similar business. One strategy that can be implemented is to integrate the product database with the creation of a membership program for customers.This research employs a prototyping approach for system development. This method divides the system into several stages that are directly implemented as models. The prototype is designed through use case diagram and activity diagram of each actor that involved in the process.As a result, a proposed design is able to control 6 control components, namely: Business Unit Admin, UPT Admin, Cashier, Shopkeeper, and Customer. On the other hand, the integration between the Point of Sales System and Membership can be seen in the key activities of customers and cashiers, where both parties will collaborate in controlling the transaction status, showing availability of special offers for members in the form of points or discounts, and calculating the appropriate offers for the completed transactions.
Characterizations of transcendental entire solutions of trinomial partial differential-difference equations in ℂ2#
Authors: Xu Hong Yan , Haldar Goutam 
Published: November 2024

Abstract
This study is devoted to exploring the existence and the precise form of finite-order transcendental entire solutions of second-order trinomial partial differential-difference equations

L

(

f

)

2

+
2
h
L

(

f

)

f

(

z

1

+

c

1

,

z

2

+

c

2

)

+
f

(

z

1

+

c

1

,

z

2

+

c

2

)

2

=

e

g

(

z

1

,

z

2

)

L{(f)}^{2}+2hL(f)f\left({z}_{1}+{c}_{1},{z}_{2}+{c}_{2})+f{\left({z}_{1}+{c}_{1},{z}_{2}+{c}_{2})}^{2}={e}^{g\left({z}_{1},{z}_{2})}

and

L

˜

(

f

)

2

+
2
h

L

˜

(

f

)

(

f

(

z

1

+

c

1

,

z

2

+

c

2

)

−
f

(

z

1

,

z

2

)

)

+

(

f

(

z

1

+

c

1

,

z

2

+

c

2

)

−
f

(

z

1

,

z

2

)

)

2

=

e

g

(

z

1

,

z

2

)

,

\tilde{L}{(f)}^{2}+2h\tilde{L}(f)(f\left({z}_{1}+{c}_{1},{z}_{2}+{c}_{2})-f\left({z}_{1},{z}_{2}))+{(f\left({z}_{1}+{c}_{1},{z}_{2}+{c}_{2})-f\left({z}_{1},{z}_{2}))}^{2}={e}^{g\left({z}_{1},{z}_{2})},

where

L

(

f

)

L(f)

and

L

˜

(

f

)

\tilde{L}(f)

are defined in (2.1) and (2.2), respectively, and

g

(

z

)

g\left(z)

is a polynomial in

C

2

{{\mathbb{C}}}^{2}

. Our results are the extensions of some of the previous results of Liu et al. Also, we exhibit a series of examples to explain that the forms of transcendental entire solutions of finite-order in our results are precise.
Modeling high-pressure viscosities of fatty acid esters and biodiesel fuels based on modified rough hard-sphere-chain model and deep learning method
Authors: Hosseini Sayed Mostafa , Pierantozzi Mariano 
Published: November 2024

Abstract
This work aimed to demonstrate that a simple modification to the previously developed rough hard-sphere-chain (RHSC) model would significantly improve the accuracy of that model for viscosities of fatty acid esters and biodiesel fuels at extended pressures up to 200 MPa and higher isotherms. The new finding of this work is the temperature dependence of the exponential factor of the roughness factor (RF) of the earlier RHSC model as the accuracy of the original model (with an average absolute relative deviation, AARD of 8.29 % for 715 data points examined) was significantly improved achieving the AARD of 3.77 % once a universal function of reduced temperature replaced the original exponential factor of 6.4 × 10−4 for RF. Besides, the predictive capability of the modified RHSC model has been compared with original RHSC model and several previously developed semi-empirical models based on friction theory and free volume theory in literature. Expanding AARD on the progress in deep learning, our research introduces Artificial Neural Network (ANN) model that is simpler than previous models while maintaining high viscosity correlation accuracy for fatty acid esters and biodiesel fuels. The refined ANN model, with a single hidden layer and sigmoid activation function, achieved an AARD% of 0.78 %. Additionally, we conducted a thorough comparison with other deep learning architectures, affirming the effectiveness of our simplified approach for viscosity correlations.
On the δ-chromatic numbers of the Cartesian products of graphs
Authors: Tangjai Wipawee , Pho-on Witsarut , Vichitkunakorn Panupong 
Published: November 2024

Abstract
In this work, we study the

δ

\delta

-chromatic number of a graph, which is the chromatic number of the

δ

\delta

-complement of a graph. We give a structure of the

δ

\delta

-complements and sharp bounds on the

δ

\delta

-chromatic numbers of the Cartesian products of graphs. Furthermore, we compute the

δ

\delta

-chromatic numbers of various classes of Cartesian product graphs, including the Cartesian products among cycles, paths, and stars.
Harnessing synthetic microbial communities with nitrogen-fixing activity to promote rice growth
Authors: Tran Van Chi , Nguyen Thanh Hai , Hoang Thi Lan Anh , Pham Thi Tuyet Mai , Nguyen Tuan Manh , Tran Trong Dai , Nguyen Thi Huong Giang , Han Viet-Cuong , Tran Anh Tuan , La Van Hien 
Published: November 2024

Abstract
Improving the biological nitrogen fixation of rhizosphere bacteria in rice is expected to improve plant growth and productivity. Most studies have focused on the application of a single N2-fixing bacterium on rice plants. Little is known about the beneficial impacts of a bacterial consortium, which is known as the microbial synthetic community (SynCom) on rice growth, and the extent of the interaction with the microbial community. The study investigated the effect of a SynCom on rice growth and productivity. A SynCom consisting of three bacteria Azosprillium sp. NL1, Bradyrhizobium sp. NL2, and Azotobacter sp. NL3 was designed to increase the survival and density of root microorganisms. The microbial culture collections used for the reconstitution experiment were established using bacterium-free soil. A profound increase in bacterial root microbiota survival and density was observed in plants inoculated with either mono- or multi-synthetic microbial consortia. SynCom is essential for rice plant growth by improving shoot ramification and root development. The results showed that SynCom could increase the total root nitrogen-fixing (%Ndfa) value by 51.6%, with Azotobacter sp. NL3 being the most dominant. High levels of indole acetic acid production in the range of 0.65–0.8 ng per g root were observed in Azosprillium sp. NL1 and Azotobacter sp. NL3. This indicates Azotobacter sp. NL3 is a nitrogen-fixing rhizosphere bacterium that is dominant in rice-amended soils. These results support the early application of the designed SynCom as a feasible strategy for the induction of nitrogen fixation, suggesting a role for earlier effects on rhizosphere colonization and tillering of plants.
Thermo-mechanical coupling behavior of needle-punched carbon/carbon composites
Authors: Han Meng , Zhang Xingyu , Wang Zhichao , Silberschmidt Vadim V. , Bi Qinsheng 
Published: November 2024

Abstract
Needle-punched carbon/carbon (NP C/C) composites are widely used in thermal protection systems for aerospace engineering. Oxidation and ablation affect their mechanical properties at high temperatures of service environment. A thermo-mechanical coupling model is proposed to predict the residual strength of oxidized bundles. A multiscale oxidation behavior of an NP C/C composite is simulated to investigate the progressive damage and oxidation of structures with thermo-mechanical coupling effects. Uniaxial tension experiments on the NP C/C composite were carried out at room temperature and 750°C to verify the proposed model. It is shown that mechanical properties of the composite decreased significantly after oxidation at 750°C-up to 40%, while the ultimate strain reduced by 5%. The proposed thermo-mechanical coupling model could be used to predict the failure and residual mechanical properties caused by the oxidation process.
Spatial pedagogy: exploring semiotic functions of one teacher’s movement in an Active Learning Classroom
Authors: Wu Xiaoqin 
Published: November 2024

Abstract
A teacher’s use of classroom space via embodied movement enacts a specific spatial pedagogy and has a significant impact on the nature of teaching and learning that can take place. The ubiquity and large expenditure in renovating university learning environments have not been accompanied by well-informed research due to a tendency to background embodied movement in pedagogic investigations. This paper explores the semiotic potentials and pedagogic functions of one teacher’s embodied movement in an Active Learning Classroom in a tertiary setting. It maps out the interrelationship of embodied movement and space as an entanglement of materiality and practice, which complements existing research that relates movement to space only in terms of layout and composition. By conducting a nuanced multimodal analysis of one teacher’s co-patterns of movement and speech in a tertiary lesson, this paper finds that co-patterns of embodied movement and speech in the classroom can segment phases of pedagogic discourse into five secondary phases and that these phases congruently enact different types of space to modulate the teacher-student relationship and enact different pedagogic roles. The paper concludes with a discussion of the implication of embodied movement on classroom design and pedagogic practice.
Inhibition of pro-inflammatory cytokines by homalolide A and homalomenol A isolated from rhizomes of Homalomena pendula
Authors: Khanh Nguyen Linh Thuy , Thi Le Hien Bich , Van Anh Tran Thi , Nguyen Hoai Thi , Ho Duc Viet , Nguyen Hien Minh 
Published: November 2024

Abstract
Inflammation, a natural process of the innate immune system, involves elevated levels of various proinflammatory mediators, such as, nitric oxide (NO) and prostaglandin (PGE2), cytokines such as interleukin 6 (IL-6), interleukin 10 (IL-10) and tumor necrosis factor alpha (TNF-α), and enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). This study investigated the anti-inflammatory effects of homalolide A (1) and homalomenol A (2), two sesquiterpenoids isolated from the rhizome of Homalomena pendula, on lipopolysaccharide (LPS)- stimulated macrophage cells. The results demonstrated that both 1 and 2 dose-dependently inhibited the production of PGE2, TNF-α and IL-6 in RAW 264.7 macrophages. Furthermore, 2 also stimulated IL-10 production in RAW 264.7 cells. Consistent with these findings, these compounds suppressed the LPS-stimulated protein levels of iNOS and COX-2 in RAW 264.7 cells. These results suggested that 1 and 2 could be effective candidates for ameliorating inflammatory-associated complications.
Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents
Authors: Abbasi Shahzad Ahmad , Rehman Wajid , Rahim Fazal , Hussain Rafaqat , Hawsawi Mohammed B. , Alluhaibi Mustafa S. , Alharbi Majed , Taha Muhammad , Khan Shoaib , Rasheed Liaqat , Wadood Abdul , Ali Shah Syed Adnan 
Published: November 2024

Abstract
Diabetes mellitus (DM) is a disorder which is raised at the alarming level and it is characterized by the hyperglycemia results from the impaired action of insulin, production of insulin or both of these simultaneously. Consequently, it causes problems or failure of different body organs such as kidneys, heart, eyes, nerve system. Since this disease cannot be completely cured until now, we aimed to design series of enzymes inhibitors and tested them for DM treatment. In this series, benzimidazole-based thiazolidinone bearing chalcone derivatives completed in a four step reaction and their structures were confirmed through various spectroscopic techniques. A significant efficacy on antidiabetic enzymes was observed, with IC50 values ranging from 25.05 ± 0.04 to 56.08 ± 0.07 μM for α-amylase and 22.07 ± 0.02 to 53.06 ± 0.07 μM for α-glucosidase. The obtained results were compared to those of the standard glimepiride drug (IC50 = 18.05 ± 0.07 µM for α-amylase and IC50 = 15.02 ± 0 .03 µM for α-glucosidase). The synthesized compounds showed promising antidiabetic potency. Moreover, a molecular docking study was conducted on the most active analogs of the compounds to better understand their interactions with the active sites of the targeted enzymes.
Evidence-Driven Approaches to Developing Specific Strength in the First Pull: A Narrative Review
Authors: Joffe Shaun A. , Chavda Shyam , Sorensen Angela , Comfort Paul 
Published: November 2024

ABSTRACT
A substantial body of literature has focused on weightlifting derivative lifts, primarily emphasizing the second pull phase because of its greater expression of force, velocity, and power output. The biomechanical resemblance of this phase to various athletic movements underscores the relevance of these derivatives in physical preparation across multiple sports. However, although the findings of these studies greatly enhance our understanding of their effectiveness in enhancing neuromuscular qualities, there remains a noticeable gap in the literature regarding the importance of the first pull phase, specifically within the sport of weightlifting. The aim of this review was to elucidate the relative importance of the first pull phase in snatch and clean & jerk performance and to explore the selection of specific pull derivative exercises that target the strength development of this phase of the lifts.