bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcatheter occlusion of giant congenital coronary cameral fistulae: a case series
Authors: Nkya Deogratias A. , Sinyangwe Greenwood , Takawira Farirai Fani 
Published: October 2019

Abstract

Background
A coronary cameral fistula is a rare connection between a coronary artery and a cardiac chamber or vein bypassing the cardiac capillary bed system. Most of these fistulae are congenital and solitary, although they can be acquired and multiple.

Cases presentation
Case 1: A 10-year-old black South African boy presented with a long-standing history of fatigue; he had a heart murmur, and a bounding pulse and wide pulse pressure. An echocardiogram demonstrated a large coronary cameral fistula involving his left coronary artery and his left ventricle. This was also confirmed on ascending aortogram. Surgical ligation was done and his symptoms improved afterward, but a small residual fistula remained. Case 2: A 7-year-old black South African boy had decreased effort tolerance and a heart murmur on the mid-sternal border. He had cardiomegaly on chest roentgenogram and a dilated left coronary artery origin on echocardiogram. An ascending aortogram confirmed a large left coronary cameral fistula draining to the left ventricle. Case 3: A 28-year-old black South African woman with decreased effort tolerance and chest pain on exertion had a continuous murmur over the lower sternal border. Echocardiography demonstrated a dilated right coronary artery with a fistulous connection to her right ventricle. An ascending aortogram demonstrated a tortuous coronary cameral fistula arising from her right coronary artery to her right ventricle. All three patients were successfully treated percutaneously using the Amplatzer vascular plug type II device.

Conclusion
The availability of numerous vascular closure devices has made transcatheter occlusion the treatment of choice for the majority of coronary cameral fistulae, rather than the traditional surgical ligation.
Changes in dynamic arterial elastance induced by volume expansion and vasopressor in the operating room: a prospective bicentre study
Authors: de Courson Hugues , Boyer Philippe , Grobost Romain , Lanchon Romain , Sesay Musa , Nouette-Gaulain Karine , Futier Emmanuel , Biais Matthieu 
Published: October 2019

Abstract

Background
Dynamic arterial elastance (Eadyn), defined as the ratio between pulse pressure variations and stroke volume variations, has been proposed to assess functional arterial load. We evaluated the evolution of Eadyn during volume expansion and the effects of neosynephrine infusion in hypotensive and preload-responsive patients.

Methods
In this prospective bicentre study, we included 56 mechanically ventilated patients in the operating room. Each patient had volume expansion and neosynephrine infusion. Stroke volume and stroke volume variations were obtained using esophageal Doppler, and pulse pressure variations were measured through the arterial line. Pressure response to volume expansion was defined as an increase in mean arterial pressure (MAP) ≥ 10%.

Results
Twenty-one patients were pressure responders to volume expansion. Volume expansion induced a decrease in Eadyn (from 0.69 [0.58–0.85] to 0.59 [0.42–0.77]) related to a decrease in pulse pressure variations more pronounced than the decrease in stroke volume variations. Baseline and changes in Eadyn after volume expansion were related to age, history of arterial hypertension, net arterial compliance and effective arterial elastance. Eadyn value before volume expansion > 0.65 predicted a MAP increase ≥ 10% with a sensitivity of 76% (95% CI 53–92%) and a specificity of 60% (95% CI 42–76%). Neosynephrine infusion induced a decrease in Eadyn (from 0.67 [0.48–0.80] to 0.54 [0.37–0.68]) related to a decrease in pulse pressure variations more pronounced than the decrease in stroke volume variations. Baseline and changes in Eadyn after neosynephrine infusion were only related to heart rate.

Conclusion
Eadyn is a potential sensitive marker of arterial tone changes following vasopressor infusion.
Controlled Multifactorial Coagulopathy: Effects of Dilution, Hypothermia, and Acidosis on Thrombin Generation In Vitro
Authors: Mitrophanov Alexander Y. , Szlam Fania , Sniecinski Roman M. , Levy Jerrold H. , Reifman Jaques 
Published: October 2019

BACKGROUND:
Coagulopathy and hemostatic abnormalities remain a challenge in patients following trauma and major surgery. Coagulopathy in this setting has a multifactorial nature due to tissue injury, hemodilution, hypothermia, and acidosis, the severity of which may vary. In this study, we combined computational kinetic modeling and in vitro experimentation to investigate the effects of multifactorial coagulopathy on thrombin, the central enzyme in the coagulation system.

METHODS:
We measured thrombin generation in platelet-poor plasma from 10 healthy volunteers using the calibrated automated thrombogram assay (CAT). We considered 3 temperature levels (31°C, 34°C, and 37°C), 3 pH levels (6.9, 7.1, and 7.4), and 3 degrees of dilution with normal saline (no dilution, 3-fold dilution, and 5-fold dilution). We measured thrombin-generation time courses for all possible combinations of these conditions. For each combination, we analyzed 2 scenarios: without and with (15 nM) supplementation of thrombomodulin, a key natural regulator of thrombin generation. For each measured thrombin time course, we recorded 5 quantitative parameters and analyzed them using multivariable regression. Moreover, for multiple combinations of coagulopathic conditions, we performed routine coagulation tests: prothrombin time (PT) and activated partial thromboplastin time (aPTT). We compared the experimental results with simulations using a newly developed version of our computational kinetic model of blood coagulation.

RESULTS:
Regression analysis allowed us to identify trends in our data (P < 10−5). In both model simulations and experiments, dilution progressively reduced the peak of thrombin generation. However, we did not experimentally detect the model-predicted delay in the onset of thrombin generation. In accord with the model predictions, hypothermia delayed the onset of thrombin generation; it also increased the thrombin peak time (up to 1.30-fold). Moreover, as predicted by the kinetic model, the experiments showed that hypothermia increased the area under the thrombin curve (up to 1.97-fold); it also increased the height of the thrombin peak (up to 1.48-fold). Progressive acidosis reduced the velocity index by up to 24%; acidosis-induced changes in other thrombin generation parameters were much smaller or none. Acidosis increased PT by 14% but did not influence aPTT. In contrast, dilution markedly prolonged both PT and aPTT. In our experiments, thrombomodulin affected thrombin-generation parameters mainly in undiluted plasma.

CONCLUSIONS:
Dilution with normal saline reduced the amount of generated thrombin, whereas hypothermia increased it and delayed the time of thrombin accumulation. In contrast, acidosis in vitro had little effect on thrombin generation.
P-cadherin-induced decorin secretion is required for collagen fiber alignment and directional collective cell migration
Authors: Le Borgne-Rochet Maïlys , Angevin Lucie , Bazellières Elsa , Ordas Laura , Comunale Franck , Denisov Evgeny V. , Tashireva Lubov A. , Perelmuter Vladimir M. , Bièche Ivan , Vacher Sophie , Plutoni Cédric , Seveno Martial , Bodin Stéphane , Gauthier-Rouvière Cécile 
Published: October 2019

ABSTRACT
Directional collective cell migration (DCCM) is crucial for morphogenesis and cancer metastasis. P-cadherin (also known as CDH3), which is a cell–cell adhesion protein expressed in carcinoma and aggressive sarcoma cells and associated with poor prognosis, is a major DCCM regulator. However, it is unclear how P-cadherin-mediated mechanical coupling between migrating cells influences force transmission to the extracellular matrix (ECM). Here, we found that decorin, a small proteoglycan that binds to and organizes collagen fibers, is specifically expressed and secreted upon P-cadherin, but not E- and R-cadherin (also known as CDH1 and CDH4, respectively) expression. Through cell biological and biophysical approaches, we demonstrated that decorin is required for P-cadherin-mediated DCCM and collagen fiber orientation in the migration direction in 2D and 3D matrices. Moreover, P-cadherin, through decorin-mediated collagen fiber reorientation, promotes the activation of β1 integrin and of the β-Pix (ARHGEF7)/CDC42 axis, which increases traction forces, allowing DCCM. Our results identify a novel P-cadherin-mediated mechanism to promote DCCM through ECM remodeling and ECM-guided cell migration.
Surpassing the subitizing threshold: appetitive–aversive conditioning improves discrimination of numerosities in honeybees
Authors: Howard Scarlett R. , Avarguès-Weber Aurore , Garcia Jair E. , Greentree Andrew D. , Dyer Adrian G. 
Published: October 2019

ABSTRACT
Animals including humans, fish and honeybees have demonstrated a quantity discrimination threshold at four objects, often known as subitizing elements. Discrimination between numerosities at or above the subitizing range is considered a complex capacity. In the current study, we trained and tested two groups of bees on their ability to differentiate between quantities (4 versus 5 through to 4 versus 8) when trained with different conditioning procedures. Bees trained with appetitive (reward) differential conditioning demonstrated no significant learning of this task, and limited discrimination above the subitizing range. In contrast, bees trained using appetitive–aversive (reward–aversion) differential conditioning demonstrated significant learning and subsequent discrimination of all tested comparisons from 4 versus 5 to 4 versus 8. Our results show conditioning procedure is vital to performance on numerically challenging tasks, and may inform future research on numerical abilities in other animals.
PALEOCENE SEISMIC FACIES IN THE CONTINENTAL MARGIN OF URUGUAY (SOUTH AMERICA)
Authors: Soto Matías , Viera Belén , Morales Ethel , Conti Bruno , Hernández-Molina Francisco Javier 
Published: October 2019

In this contribution seismic facies of the Paleocene sequence are characterized in offshore basins of Uruguay through the study of a 2D seismic database. Seven seismic horizons were identified, limiting six sedimentary intervals with different characteristics. Hence, the complexity of the Paleocene sequence is greater than suggested by other studies. Seismic facies located in the basis of the sequence can be interpreted as sandy deposits related to the action of both turbidity and bottom currents. The identification of these deposits agrees with the expected Cretaceous source rocks, in addition to the importance of the overlying Paleocene shales as a regional seal. The results of this work open interesting exploratory perspectives in the continental margin of Uruguay. FACIES SÍSMICAS DO PALEOCENE NA MARGEM CONTINENTAL DO URUGUAI (AMÉRICA DO SUL) ResumoNesta contribuição, as fácies sísmicas da sequência do Paleoceno são caracterizadas em bacias offshore do Uruguai através do estudo de uma base de dados sísmica 2D. Foram identificados sete horizontes sísmicos, limitando seis intervalos sedimentares com diferentes características. Neste estudo verifica-se que a complexidade da seqüência do Paleoceno é maior do que a sugerida por outros estudos. A fácies sísmicas localizadas na base da sequência podem ser interpretadas como sendo depósitos arenosos resultantes da ação de correntes de turbidez e de fundo. Estes depósitos correspondem a rochas-fonte cretáceas, estando cobertas regionalmente por importantes rochas selantes correspondentes a folhelhos do Paleoceno. Os resultados deste trabalho abrem interessantes perspectivas exploratórias na margem continental do Uruguai.Palavras-chave: Paleoceno. Facies Sísmicas. Margem Continental do Uruguai.
Penanganan penyakit white feces pada udang vaname Litopenaeus vannamei menggunakan aplikasi pakan yang dicampur ekstrak lengkuas merah Alpinia purpurata k. schum
Authors: Marbun Juliana , Harpeni Esti , Wardiyanto Wardiyanto 
Published: October 2019

Abstract. The main problem in vaname shrimp Litopenaeus vannamei culture is a disease. One of the diseases that can infect vaname shrimp is White Feces Disease (WFD) caused by bacteria Vibrio sp. The Treatment can be done by using Red galangal Rhizome extract. Since MBC testing result galangal extract can be a treat of Vibrio sp bacteria. This research used the completely randomized design (RAL) with five treatments and three replications which treatment A (negative control), B (positive control), C (7.5 grams), D (10 grams) and (12.5 grams) which are mixed with pellet for treating White Feces Disease in vaname shrimp. The result shows that red galangal rhizome extracted give effect to SR (Survival Rate), RPS (Relative Percent Survival), TVC (Total Vibrio Count), but it didn’t give effect to clinical indication and histopathology.Keywords: vaname shrimp, white feces disease, extract red galangal Rhizome Abstrak. Permasalahan utama dalam budidaya udang vaname (Litopenaeus vannamei) adalah penyakit, salah satu penyakit yang dapat menyerang udang vaname yaitu White Feces Disease (WFD) yang disebabkan bakteri Vibrio sp. Upaya pengobatan yang dapat dilakukan untuk menangani penyakit tersebut adalah dengan pengobatan menggunakan ekstrak rimpang lengkuas merah dikarenakan ekstrak lengkuas telah diuji secara MBC dapat mematikan bakteri Vibrio sp. Penelitian ini bertujuan untuk menguji ekstrak rimpang lengkuas merah dengan dosis berbeda yang dicampur dengan pakan buatan untuk mengobati penyakit white feces disease pada udang vaname (Litopenaeus vannamei). Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan lima perlakuan, tiga ulangan dimana perlakuan A (kontrol negatif), perlakuan B (kontrol positif), perlakuan C (7,5 g), perlakuan D (10 g) dan perlakuan E (12,5 g). Hasil penelitian menunjukan bahwa ekstrak rimpang lengkuas merah berpengaruh terhadap SR, RPS (Relative Percent Survival) dan TVC (Total Vibrio Count), namun tidak berpengaruh terhadap gejala klinis dan histopatalogi. Kata Kunci: udang vaname, white feces disease, ekstrak rimpang lengkuas merah
CONSTRUÇÃO DE UM MODELO DE EVOLUÇÃO FARMACÊUTICA EM PRONTUÁRIO MÉDICO
Authors: Amorim Samara Alves , Lima Alisson Menezes de Araújo , Neto José Martins De Alcântara , Andrade Cinthya Cavalcante de , Sidney Kamila Maria Maranhão 
Published: October 2019

Considerando a necessidade de padronizar a elaboração do registro dos cuidados prestados ao paciente, o presente trabalho propõe um modelo de nota de evolução farmacêutica para ser utilizada pelo farmacêutico clínico no âmbito hospitalar. Uma revisão de literatura do tipo narrativafoi iniciada com a questão-problema: o quê e como o farmacêutico clínico deve registrar, no prontuário do paciente em âmbito hospitalar, após realizar a anamnese farmacêutica?’’, seguida de pesquisa de artigos nas bases de dados Lilacs, Scielo e PubMed, e posteriormente, de uma análise crítica e da seleção de trabalhos para a construção da proposta de evolução farmacêutica. Foram selecionados 10 artigos e 2 guias. Foi feita a opção pela organização dos dados a partir do método SOAP, que é um acrônimo no qual cada letra representa uma das seções das anotações da evolução, ou seja, os dados subjetivos (S), os dados objetivos (O), a avaliação (A) e o planejamento (P). Os dados abordados visaram garantir que toda a farmacoterapia do paciente esteja adequada para tratar os problemas de saúde. Documentar, de forma padronizada, os cuidados farmacêuticos prestados na otimização da farmacoterapia do paciente, é uma etapa necessária na melhoria da comunicação nas equipes multiprofissionais. Assim, a proposta de evolução farmacêutica pode ser útil, por abordar quais informações são relevantes e como organizá-las dentro do SOAP.
ANÁLISES DE QUALIDADE DE XAMPUS DE CETOCONAZOL 2% MANIPULADOS EM FARMÁCIAS MAGISTRAIS DE PORTO VELHO, RO, BRASIL
Authors: Xavier Lopes Eva Maria , Moreira de Castilho Fábio Lopes , Freire de Castro Victória Carolina 
Published: October 2019

Os xampus são produtos para a limpeza ou fixação de substâncias com ação dermatológica. Xampus de Cetoconazol têm a finalidade de tratar e prevenir infecções fúngicas causadas por Malassezia globosa. Por serum xampu de alto consumo pela população, faz-se necessária a confirmação da qualidade dos produtos manipulados nas farmácias magistrais. O objetivo deste trabalho foi realizar análises de qualidade dos xampus de cetoconazol manipulados em farmácias magistrais de Porto Velho, RO. Foram realizadas análises organolépticas,potencial hidrogeniônico (pH), determinação da densidade, viscosidade, potencial espumante, teste de centrifugação e doseamento espectrofotométrico. Após analisar as cinco amostras manipuladas todas foram satisfatórias quanto à análise organoléptica; em relação ao pH, apenas a amostra B mostrou-se dentro dos padrões. Na determinação da densidade, as amostras A e C se mostraram satisfatórias. Quanto àviscosidade, apenas a E se mostrou insatisfatória; o poder espumante e o doseamento não foi aceitável para as amostras D e E. No teste de centrifugação, as formulações A, D e E formaram precipitados.
O USO DE PSICOFÁRMACOS POR CRIANÇAS E ADOLESCENTES EM UM CENTRO DE ATENÇÃO PSICOSSOCIAL INFANTIL
Authors: Silva Orfila Rafaela Trindade da , Silveira Michele Marinho da 
Published: October 2019

Nas últimas décadas houve um aumento significativo de crianças e adolescentes submetidas a tratamento psicofarmacológico. Há um crescente número de medidas interventivas médico-pedagógicas, a partirda proliferação de diagnósticos e prescrições de medicamentos para esta parcela da população. Assim, o objetivo foi verificar a utilização de psicofármacos por crianças e adolescentes de um Centro de AtençãoPsicossocial Infantil (CAPSi), por meio de uma pesquisa retrospectiva e transversal, com dados de 319 prontuários de um CAPSi da região norte do Rio Grande do Sul, no período de janeiro de 2016 a dezembro de 2017. Entre as crianças e adolescentes que frequentavam o CAPSi 66,7% faziam uso de psicofármacos, entre eles, os mais prescritos foram o antipsicótico risperidona com 36,3% e o estimulante metilfenidato15,8%. A maioria dos usuários de psicofármacos era do sexo masculino (44,5%), com maior prevalência de transtorno de déficit de atenção e hiperatividade (17,9%) e sintomas depressivos (8,5%), encaminhadospelo Centro Municipal de Atendimento Especializado (27,3%) e Conselho Tutelar )16,6%). Portanto, este estudo revelou um uso elevado de psicofármacos e, consequentemente, medicamentos usados com hipóteses diagnósticas ou sem um diagnóstico, tratando sintomas advindos de demanda escolar e familiar.
The formation of scientific and research andragogy centres in the Second Republic of Poland
Authors: Stopińska-Pająk Agnieszka 
Published: October 2019

The article shows the process of institutionalising andragogy in Poland. The author discusses the development of the first research institutions that gave raise to andragogical research in the Second Polish Republic (1918-1939). Special attention is given to academic centres, their representatives and the research projects they completed. The author shows also that while not widely popular, andragogy has an established position in university communities.
The Possibility of Utilization of Sewage Sludge as a Filler in Production of the Lightweight Aggregate Concrete
Authors: Suchorab Zbigniew , Barnat-Hunek Danuta , Franus Małgorzata , Łagód Grzegorz , Pavlík Zbyšek 
Published: October 2019

Abstract
The article presents the laboratory investigations of the basic thermal and hygric parameters of standard lightweight aggregate-concrete and lightweight aggregate-concrete supplemented with municipal sewage sludge. Both types of concrete are based on light aggregates, commonly used in the Polish building market. In order to improve the hygric parameters of the material, such as water absorptivity, the admixture of water emulsion of reactive polisiloxanes was applied. Within the presented research, together with basic moisture parameters estimation, capillary rise process was monitored using Time Domain Reflectometry (TDR) modified sensors. Hygric parameters were supplemented with the estimation of thermal conductivity coefficient λ determined using stationary method. The analysis of thermal and hygric properties of concrete confirmed the applicability of lightweight aggregate-concrete with sewage sludge supplementation for further production.
The adjustment of 17-hydroxyprogesterone cut-off values for congenital adrenal hyperplasia neonatal screening by GSP according to gestational age and age at sampling
Authors: Jiang Xiang , Tang Fang , Feng Yi , Li Bei , Jia Xuefang , Tang Chengfang , Liu Sichi , Huang Yonglan 
Published: October 2019

Abstract

Background
Congenital adrenal hyperplasia (CAH) screening is facing great challenges because of a high false-positive rate and a low positive predictive value (PPV). We established and optimized 17-hydroxyprogesterone (17-OHP) cut-off values for CAH neonatal screening using a genetic screening processor (GSP) according to gestational age (GA), birth weight (BW) and age at sampling.

Methods
The 17-OHP concentrations in dried blood spots were measured by time-resolved immunofluorescence and were grouped in terms of GA, BW and age at sampling for 48,592 newborns. The 99.5th percentile was used to set an initial cut-off value as a reference.

Results
Significant differences in 17-OHP concentrations were observed among newborns with different GAs and BWs. A significant difference was observed among different sampling age groups. Finally, we defined new multitier cut-off concentrations based on GA and age at sampling. Application of the new cut-off values resulted in a 30% reduction of the positive rate and a 40% increase of the PPV.

Conclusions
GA, BW and sampling age time influenced the concentrations of 17-OHP. The efficiency of congenital adrenal hyperplasia screening can be substantially improved by adjusting the multitier cut-off value according to GA and age at sampling.
Crystal structure of bis{(N-[(5-chloro-2-oxidophenyl)methylidene]-2-hydroxybenzenecarbohydrazonato)-dioxo-molybdenum(VI)}(μ2-4,4′-bipyridine), C38H26Cl2Mo2N6O10
Authors: Lo Kong Mun , Lee See Mun , Tiekink Edward R.T. 
Published: October 2019

Abstract
C38H26Cl2Mo2N6O10, triclinic, P1̄ (no. 2), a = 7.7151(2) Å, b = 10.5336(2) Å, c = 12.5668(2) Å, α = 73.027(2)°, β = 76.226(2)°, γ = 72.269(2)°, V = 917.83(4) Å3, Z = 1, R
gt(F) = 0.0234, wR
ref(F
2) = 0.0612, T = 100(2) K.
2D GeSe2 amorphous monolayer
Authors: Zhang Bo , Mikysek Tomas , Cicmancova Veronika , Slang Stanislav , Svoboda Roman , Kutalek Petr , Wagner Tomas 
Published: October 2019

Abstract
In this paper, GeSe2 thin film and glass ingot were prepared in a layered structure. Subsequently, the 2D amorphous monolayers were achieved from layered thin film and layered glass ingot. The thicknesses of monolayers from thin film range from 1.5 nm to 5 nm. And the thickness of monolayer from glass ingot is 7 μm. The fast cooling of material results in the formation of self-assembled monolayers. In the case of thin film, layers are connected with “bridge”. After doping of Ag, the precipitation of nano particles exfoliates the adjacent monolayers which can be further dispersed by etching of Ag particles. In the case of glass ingot, the composition changes at 1 % between adjacent monolayers, according to EDX (energy-dispersive X-ray spectroscopy) spectra. And the glass 2D monolayer can be mechanically peeled off from the glass ingot.