bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feeling for Freedom: K. C. Bhattacharyya on Rasa
Authors: Lopes Dominic McIver 
Published: April 2019

Abstract
Aesthetic hedonists agree that an aesthetic value is a property of an item that stands in some constitutive relation to pleasure. Surprisingly, however, aesthetic hedonists need not reduce aesthetic normativity to hedonic normativity. They might demarcate aesthetic value as a species of hedonic value, but deny that the reason we have to appreciate an item is simply that it pleases. Such is the approach taken by an important strand of South Asian rasa theory that is represented with great clarity and ingenuity in the work of K. C. Bhattacharyya. Bhattacharyya is an aesthetic hedonist who grounds aesthetic normativity in freedom.
Inappropriate Empirical Antibiotic Treatment in High-risk Neutropenic Patients With Bacteremia in the Era of Multidrug Resistance
Authors: Martinez-Nadal Gemma , Puerta-Alcalde Pedro , Gudiol Carlota , Cardozo Celia , Albasanz-Puig Adaia , Marco Francesc , Laporte-Amargós Júlia , Moreno-García Estela , Domingo-Doménech Eva , Chumbita Mariana , Martínez José Antonio , Soriano Alex , Carratalà Jordi , Garcia-Vidal Carolina 
Published: April 2019

Abstract

Background
We aimed to describe the current rates of inappropriate empirical antibiotic treatment (IEAT) in oncohematological patients with febrile neutropenia (FN) and its impact on mortality.

Methods
This was a multicenter prospective study of all episodes of bloodstream infection (BSI) in high-risk FN patients (2006–2017). Episodes receiving IEAT were compared with episodes receiving appropriate empirical therapy. Adherence to Infectious Diseases Society of America (IDSA) recommendations was evaluated. Multivariate analysis was performed to identify independent risk factors for mortality in Pseudomonas aeruginosa episodes.

Results
Of 1615 episodes, including Escherichia coli (24%), coagulase-negative staphylococci (21%), and P. aeruginosa (16%), 394 (24%) received IEAT despite IDSA recommendations being followed in 87% of cases. Patients with multidrug-resistant gram-negative bacilli (MDR-GNB), accounting for 221 (14%) of all isolates, were more likely to receive IEAT (39% vs 7%, P &lt; .001). Overall mortality was higher in patients with GNB BSI who received IEAT (36% vs 24%, P = .004); when considering individual microorganisms, only patients with infection caused by P. aeruginosa experienced a significant increase in mortality when receiving IEAT (48% vs 31%, P = .027). Independent risk factors for mortality in PA BSI (odds ratio [95% confidence interval] were IEAT (2.41 [1.19–4.91]), shock at onset (4.62 [2.49–8.56]), and pneumonia (3.01 [1.55–5.83]).

Conclusions
IEAT is frequent in high-risk patients with FN and BSI, despite high adherence to guidelines. This inappropriate treatment primarily impacts patients with P. aeruginosa–related BSI mortality and in turn is the only modifiable factor to improve outcomes.
Prognosis and long-term outcomes of acute kidney injury due to snake envenomation
Authors: Priyamvada P S , Jaswanth Challa , Zachariah Bobby , Haridasan Satish , Parameswaran Sreejith , Swaminathan Rathinam Palamalai 
Published: April 2019

Abstract

Background
Snakebite is a common occupational hazard in tropical countries. To date, the literature on snakebite-related acute kidney injury (AKI) has been limited by retrospective study designs, lack of uniformity in case definitions of AKI and limited follow-up. This study aims to identify the in-hospital outcomes and long-term changes in kidney function that follow haemotoxic envenomation.

Methods
All adult patients admitted with AKI following haemotoxic envenomation from January 2016 to June 2017 were recruited and followed up until July 2018. Predictors of in-hospital mortality was assessed. Long-term follow-up data on kidney function were collected from survivors.

Results
In total, 184 patients with haemotoxic envenomation and AKI were recruited. The mean age of the subjects was 42.2 years [95% confidence interval (CI) 40.3–44.7]. The majority were male (71.2%). The mortality of patients with haemotoxic envenomation was 21.5%. The mortality was considerably higher in patients with Kidney Disease: Improving Global Outcomes (KDIGO) Stage 3 AKI [relative risk (RR) 4.45 (95% CI 1.14–17.42)] and those who met KDIGO urine output criteria [RR 20.45 (95% CI 2.84–147.23)]. A Cox regression model identified mechanical ventilation [odds ratio (OR) 5.59 (95% CI 2.90–10.81)], hypotension [OR 2.48 (95% CI 1.31–4.72)] and capillary leak syndrome [OR 2.02 (95% CI 1.05–3.88)] as independent predictors of mortality. Long-term follow-up data were available for 73 patients. A total of 21 patients (28.7%) developed adverse renal outcomes (glomerular filtration rate &lt;60 mL/min/1.73 m2, urine albumin excretion &gt;30 mg/g and new-onset hypertension or prehypertension).

Conclusions
AKI resulting from snake envenomation is associated with considerable risk of mortality. The greater the AKI stage the greater the likelihood of mortality. One-third of patients with AKI developed long-term complications like chronic kidney disease, prehypertension and hypertension over the follow-up period.
Boat-towed radio-magnetotelluric and controlled source audio-magnetotelluric study to resolve fracture zones at Äspö Hard Rock Laboratory site, Sweden
Authors: Wang Shunguo , Bastani Mehrdad , Constable Steven , Kalscheuer Thomas , Malehmir Alireza 
Published: April 2019

SUMMARY
Boat-towed radio-magnetotelluric (RMT) measurements using signals between 14 and 250 kHz have attracted increasing attention in the near-surface applications for shallow water and archipelago areas. A few large-scale underground infrastructure projects, such as the Stockholm bypass in Sweden, are planned to pass underneath such water zones. However, in cases with high water salinity, RMT signals have a penetration depth of a few metres and do not reach the geological structures of interest in the underlying sediments and bedrock. To overcome this problem, controlled source signals at lower frequencies of 1.25 to 12.5 kHz can be utilized to improve the penetration depth and to enhance the resolution for modelling deeper underwater structures. Joint utilization of boat-towed RMT and controlled source audio-magnetotellurics (CSAMT) was tested for the first time at the Äspö Hard Rock Laboratory (HRL) site in south-eastern Sweden to demonstrate acquisition efficiency and improved resolution to model fracture zones along a 600-m long profile. Pronounced galvanic distortion effects observed in 1-D inversion models of the CSAMT data as well as the predominantly 2-D geological structures at this site motivated usage of 2-D inversion. Two standard academic inversion codes, EMILIA and MARE2DEM, were used to invert the RMT and CSAMT data. EMILIA, an object-oriented Gauss–Newton inversion code with modules for 2-D finite difference and 1-D semi-analytical solutions, was used to invert the RMT and CSAMT data separately and jointly under the plane-wave approximation for 2-D models. MARE2DEM, a Gauss–Newton inversion code for controlled source electromagnetic 2.5-D finite element solution, was modified to allow for inversions of RMT and CSAMT data accounting for source effects. Results of EMILIA and MARE2DEM reveal the previously known fracture zones in the models. The 2-D joint inversions of RMT and CSAMT data carried out with EMILIA and MARE2DEM show clear improvement compared with 2-D single inversions, especially in imaging uncertain fracture zones analysed in a previous study. Our results show that boat-towed RMT and CSAMT data acquisition systems can be utilized for detailed 2-D or 3-D surveys to characterize near-surface structures underneath shallow water areas. Potential future applications may include geo-engineering, geohazard investigations and mineral exploration.
Localized Control of Aedes aegypti (Diptera: Culicidae) in Miami, FL, via Inundative Releases of Wolbachia-Infected Male Mosquitoes
Authors: Mains James W , Kelly Patrick H , Dobson Karen L , Petrie William D , Dobson Stephen L 
Published: April 2019

AbstractAs part of the response to autochthonous Zika transmission in the United States, the City of South Miami implemented a 6-mo period in which Wolbachia-infected WB1 Aedes aegypti (L.) males were released into an ~170-acre area. Intracellular Wolbachia bacteria infections in Ae. aegypti cause early embryonic arrest (known as cytoplasmic incompatibility [CI]) and egg hatch failure, and inundative introductions have been suggested as a potential control tool. Throughout the release period, the Ae. aegypti population was monitored within both the release area and an equivalent area that did not receive WB1 male releases. The results show a significant reduction in egg hatch at the area receiving WB1 males, which is consistent with expectations for CI. Similarly, the number of Ae. aegypti was significantly reduced at the area receiving WB1 males, relative to the untreated area. The observed population reduction and results encourage additional work and replication of the Wolbachia biopesticide approach against Ae. aegypti, as an additional tool to be integrated with existing control tools for the control of this medically important vector and nuisance pest.
Enterococcus hirae Bacteremia in an Infant: Case Report and Review of the Literature
Authors: Brayer Samuel , Linn Alexandra , Holt Stephanie , Ellery Kate , Mitchell Stephanie , Williams John 
Published: April 2019

Abstract
Enterococcus hirae is a gram-positive coccus that is rarely implicated in human disease and has not been reported in pediatric patients. We report a case of catheter-associated bloodstream infection and prolonged bacteremia in a 7-month-old infant dependent on total parenteral nutrition. The species was identified by the VITEK2 system and confirmed by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. The organisms was susceptible to ampicillin, vancomycin, and high-level gentamicin. The patient was treated with vancomycin and gentamicin with adjunctive vancomycin lock therapy but had persistent bacteremia. Therapy was changed to dual β-lactam therapy of ampicillin and ceftriaxone with synergistic gentamicin, which led to clearance of the enterococcal bacteremia. E hirae is an unusual species that may be difficult for the microbiology laboratory to identify. This is the first pediatric case and the second case of invasive E hirae in the United States.
SN 2016B a.k.a. ASASSN-16ab: a transitional Type II supernova
Authors: Dastidar Raya , Misra Kuntal , Singh Mridweeka , Sahu D K , Pastorello A , Gangopadhyay Anjasha , Tomasella L , Benetti S , Terreran G , Sanwal Pankaj , Kumar Brijesh , Singh Avinash , Kumar Brajesh , Anupama G C , Pandey S B 
Published: April 2019

AbstractWe present photometry, polarimetry, and spectroscopy of the Type II supernova ASASSN-16ab/SN 2016B in PGC 037392. The photometric and spectroscopic follow-up commenced about 2 weeks after shock breakout and continued until nearly 6 months. The light curve of SN 2016B exhibits intermediate properties between those of Type IIP and IIL. The early decline is steep (1.68 ± 0.10 mag 100 d−1), followed by a shallower plateau phase (0.47 ± 0.24 mag 100 d−1). The optically thick phase lasts for 118 d, similar to Type IIP. The 56Ni mass estimated from the radioactive tail of the bolometric light curve is 0.082 ± 0.019 M⊙. High-velocity component contributing to the absorption trough of H α and H β in the photospheric spectra are identified from the spectral modelling from about 57–97 d after the outburst, suggesting a possible SN ejecta and circumstellar material interaction. Such high-velocity features are common in the spectra of Type IIL supernovae. By modelling the true bolometric light curve of SN 2016B, we estimated a total ejected mass of ∼15 M⊙, kinetic energy of ∼1.4 foe, and an initial radius of ∼400 R⊙.
Smartphone Use and Interest in a Spine Surgery Recovery Mobile Application Among Patients in a US Academic Neurosurgery Practice
Authors: Nathan Jay K , Rodoni Bridger M , Joseph Jacob R , Smith Brandon W , Park Paul 
Published: April 2019

Abstract

BACKGROUND
Mobile applications (apps) are serving an increasingly important role in healthcare for patients and providers alike. In addition to streamlining active communication of patient-reported outcomes regarding quality of life, pain, and opioid consumption, smartphones equipped with activity tracking afford the opportunity to passively and objectively measure mobility, a key metric of recovery in spine surgery. However, app development is a resource-intensive process.

OBJECTIVE
To survey adult neurosurgery patients regarding access to and interest in this platform.

METHODS
In June and July 2017, a paper-based anonymous survey was distributed to patients in the waiting room of the adult neurosurgery clinic of a large US academic medical center. Patients’ smartphone use and interest in using a mobile app following spine surgery were the primary and secondary outcomes, respectively.

RESULTS
Of 146 included responses, 102 patients (70%) regularly used a smartphone, and this number increased to 77% among patients with a history of spine surgery (n = 66, 45% of respondents). Seventy-one percent of patients with previous spine surgery expressed an interest in using a postoperative monitoring and communication app, compared to 81% of patients without prior spine operations (n = 80, 55%).

CONCLUSION
Among neurosurgery patients, there is a high level of access to and interest in smartphone apps to aid postoperative recovery. These results are useful for other neurosurgeons considering mobile app development for this purpose.
Inequality and market concentration, when shareholding is more skewed than consumption
Authors: Gans Joshua , Leigh Andrew , Schmalz Martin , Triggs Adam 
Published: April 2019

AbstractEconomic theory suggests that monopoly prices hurt consumers but benefit shareholders. But in a world where individuals or households can be both consumers and shareholders, the impact of market power on inequality depends in part on the relative distribution of consumption and corporate equity ownership across individuals or households. The paper calculates this distribution for the United States, using data from the Survey of Consumer Finances and the Consumer Expenditure Survey, spanning nearly three decades from 1989 to 2016. In 2016, the top 20 per cent consumed approximately as much as the bottom 60 per cent, but had 15 times as much corporate equity. Because ownership is more skewed than consumption, increased mark-ups increase inequality. Moreover, over time, corporate equity has become even more skewed relative to consumption.
Cardiac tissue-derived extracellular matrix scaffolds for myocardial repair: advantages and challenges
Authors: KC Pawan , Hong Yi , Zhang Ge 
Published: April 2019

AbstractDecellularized extracellular matrix (dECM) derived from myocardium has been widely explored as a nature scaffold for cardiac tissue engineering applications. Cardiac dECM offers many unique advantages such as preservation of organ-specific ECM microstructure and composition, demonstration of tissue-mimetic mechanical properties and retention of biochemical cues in favor of subsequent recellularization. However, current processes of dECM decellularization and recellularization still face many challenges including the need for balance between cell removal and extracellular matrix preservation, efficient recellularization of dECM for obtaining homogenous cell distribution, tailoring material properties of dECM for enhancing bioactivity and prevascularization of thick dECM. This review summarizes the recent progresses of using dECM scaffold for cardiac repair and discusses its major advantages and challenges for producing biomimetic cardiac patch.
What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil
Authors: Silveira Fernando T 
Published: April 2019

Abstract
American cutaneous leishmaniasis (ACL) is a parasitic protozoan disease caused by different Leishmania species widely distributed throughout Latin America. Fifteen Leishmania species belonging to the subgenera Viannia, Leishmania and Mundinia are known to cause ACL. Seven of these species are found in Brazil, of which Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis have the highest potential to cause mucosal (ML) and anergic diffuse cutaneous leishmaniasis (DCL), respectively, the most severe forms of ACL. The clinical and immunopathological differences between these two clinical forms are reviewed here, taking into account their different physiopathogenic mechanisms of dissemination from cutaneous lesions to mucosal tissues in the case of ML and to almost all body surfaces in the case of anergic DCL. We also discuss some immunopathogenic mechanisms of species-specific Leishmania antigens (from the subgenera Viannia and Leishmania) that are most likely associated with the clinical and immunopathological differences between ML and anergic DCL. Those discussions emphasize the pivotal importance of some surface antigens of L. (V.) braziliensis and L. (L.) amazonensis, such as lipophosphoglycan, phosphatidylserine and CD200 (an immunoregulatory molecule that inhibits macrophage activation), that have been shown to exert strong influences on the clinical and immunopathological differences between ML and anergic DCL.
A Statewide Curriculum Model for Teaching Simulation Education Leaders
Authors: Beroz Sabrina , Schneidereith Tonya , Farina Crystel L. , Daniels Amy , Dawson Lauren , Watties-Daniels Denyce , Sullivan Nancy 
Published: April 2019

Background
The Maryland Clinical Simulation Resource Consortium (MCSRC) was funded to increase the quality and quantity of simulation used in nursing education.

Problem
Schools of nursing are substituting simulation for clinical experience without requisite knowledge of simulation pedagogy.

Approach
The MCSRC developed a statewide curriculum model for a 3-day train-the-trainer program framed in theory and grounded in evidence. The program teaches nurse educators across 3 levels: novice, competent, and expert.

Outcomes
The evaluation plan was developed using Kirkpatrick's 4 levels to measure outcomes of the program. Self-confidence, satisfaction, knowledge, and behavioral changes have been realized. Nurse educators are now using theory, standards, and guidelines when conducting simulation-based experiences.

Conclusions
The curriculum model has proved effective in increasing the quality and quantity of simulation used in educating Maryland's nurses. To date, 154 nurse educators have participated in the train-the-trainer program.
Academic Activities Abroad
Authors: Lasater Kathie 
Published: April 2019

Background
Nursing students need an understanding of global health concepts in the 21st century. Patients and/or populations may come from anywhere in the world, some of whom may be seeking refuge from conflict and/or war. In addition, nurses may be employed in other countries.

Problem
Nurse educators may not have international experiences or know about global opportunities or how to navigate them.

Approach
Fulbright Scholar Awards are one way for nursing educators to experience academic opportunities in another country, working with international colleagues and/or students.

Outcomes
One nurse educator describes her experience from successful application through the postaward period.

Conclusions
Fulbright offers opportunities for academics to engage in teaching and/or research, work with international colleagues, and be immersed in other cultures. Such experiences can equip nurse educators with more comprehensive global perspectives for preparing future nurses.
Development of a New Measure to Assess Primary Palliative Care Perceived Competence
Authors: Lippe Megan , Davis Andra , Threadgill Hunter , Ricamato Allison 
Published: April 2019

Background
Many nursing schools have begun to address the gap in palliative care education. Recently released entry-to-practice competencies in palliative care can guide educators as they incorporate such material into their curriculum. In an effort to evaluate learning, educators need a reliable instrument that aligns with the updated competencies.

Purpose
This article describes the development of a new instrument to evaluate perceived competence to provide primary palliative care.

Methods
The psychometric properties and performance of the new instrument in evaluating perceived competence were tested via an interprofessional palliative care simulation with medical, nursing, and social work students. Perceived competence was measured before and after the simulation.

Results
The new instrument demonstrates strong reliability and validity, represents a unidimensional construct, and captures changes in perceived competence across time and disciplines.

Conclusions
The new instrument is acceptable for assessing perceived competence to provide palliative care, particularly for nursing students.
The Cognitive Lens: a primer on conceptual tools for analysing information processing in developmental and regenerative morphogenesis
Authors: Manicka Santosh , Levin Michael 
Published: April 2019

Brains exhibit plasticity, multi-scale integration of information, computation and memory, having evolved by specialization of non-neural cells that already possessed many of the same molecular components and functions. The emerging field of basal cognition provides many examples of decision-making throughout a wide range of non-neural systems. How can biological information processing across scales of size and complexity be quantitatively characterized and exploited in biomedical settings? We use pattern regulation as a context in which to introduce the Cognitive Lens—a strategy using well-established concepts from cognitive and computer science to complement mechanistic investigation in biology. To facilitate the assimilation and application of these approaches across biology, we review tools from various quantitative disciplines, including dynamical systems, information theory and least-action principles. We propose that these tools can be extended beyond neural settings to predict and control systems-level outcomes, and to understand biological patterning as a form of primitive cognition. We hypothesize that a cognitive-level information-processing view of the functions of living systems can complement reductive perspectives, improving efficient top-down control of organism-level outcomes. Exploration of the deep parallels across diverse quantitative paradigms will drive integrative advances in evolutionary biology, regenerative medicine, synthetic bioengineering, cognitive neuroscience and artificial intelligence.This article is part of the theme issue ‘Liquid brains, solid brains: How distributed cognitive architectures process information’.
Plant behaviour in response to the environment: information processing in the solid state
Authors: Duran-Nebreda Salva , Bassel George W. 
Published: April 2019

Information processing and storage underpins many biological processes of vital importance to organism survival. Like animals, plants also acquire, store and process environmental information relevant to their fitness, and this is particularly evident in their decision-making. The control of plant organ growth and timing of their developmental transitions are carefully orchestrated by the collective action of many connected computing agents, the cells, in what could be addressed as distributed computation. Here, we discuss some examples of biological information processing in plants, with special interest in the connection to formal computational models drawn from theoretical frameworks. Research into biological processes with a computational perspective may yield new insights and provide a general framework for information processing across different substrates.This article is part of the theme issue ‘Liquid brains, solid brains: How distributed cognitive architectures process information’.