bluuebunny/crossref_metadata_2025_split huggingface dataset:
T-Box20 inhibits osteogenic differentiation in adipose-derived human mesenchymal stem cells: the role of T-Box20 on osteogenesis
Authors: Mollazadeh Samaneh , Fazly Bazzaz Bibi Sedigheh , Neshati Vajiheh , de Vries Antoine A. F. , Naderi-Meshkin Hojjat , Mojarad Majid , Neshati Zeinab , Kerachian Mohammad Amin 
Published: September 2019

AbstractBackgroundSkeletal development and its cellular function are regulated by various transcription factors. The T-box (Tbx) family of transcription factors have critical roles in cellular differentiation as well as heart and limbs organogenesis. These factors possess activator and/or repressor domains to modify the expression of target genes. Despite the obvious effects ofTbx20on heart development, its impact on bone development is still unknown.MethodsTo investigate the consequence by forcedTbx20expression in the osteogenic differentiation of human mesenchymal stem cells derived from adipose tissue (Ad-MSCs), these cells were transduced with a bicistronic lentiviral vector encodingTbx20and an enhanced green fluorescent protein.ResultsTbx20gene delivery system suppressed the osteogenic differentiation of Ad-MSCs, as indicated by reduction in alkaline phosphatase activity and Alizarin Red S staining. Consistently, reverse transcription-polymerase chain reaction analyses showed thatTbx20gain-of-function reduced the expression levels of osteoblast marker genes in osteo-inductive Ad-MSCs cultures. Accordingly,Tbx20negatively affected osteogenesis through modulating expression of key factors involved in this process.ConclusionThe present study suggests thatTbx20could inhibit osteogenic differentiation in adipose-derived human mesenchymal stem cells.
Metagenome of a polluted river reveals a reservoir of metabolic and antibiotic resistance genes
Authors: Mittal Parul , Prasoodanan PK Vishnu , Dhakan Darshan B. , Kumar Sanjiv , Sharma Vineet K. 
Published: September 2019

Abstract

Background
Yamuna, a major tributary of Ganga, which flows through the national capital region of Delhi, is among the major polluted rivers in India. The accumulation of various effluents, toxic chemicals, heavy metals, and increased organic load in the Yamuna directly affects the organisms that thrive inside or around this river. It also makes it an ideal site for studying the impact of pollution on the river microflora, which are sentinels of the water quality.

Results
In this study, the microbial community structure and functional diversity of the Yamuna river water was assessed from the New Delhi region. The community structure of Yamuna during pre-monsoon (June) was found to be significantly different from the post-monsoon (November) time, with Acinetobacter being the most abundant genus during June, and Aeromonas during November. The functional characterization revealed the higher abundance of Methyl-accepting chemotaxis protein in the river water, which could be important for the microbial chemosensory adaptation in the environment. A higher abundance of genes related to nitrogen and sulfur metabolism, metal tolerance, and xenobiotic degradation, and complete degradation pathways of aromatic compounds such as toluene, xylene, benzene and phenol were identified. Further, the results showed the presence of a pool of antibiotic resistance genes in the bacterial microbiome in the Yamuna alongside a large number of broad-spectrum antibiotics, such as carbapenemases and metallo-β-lactamases. Efflux mechanism of resistance was found to dominate among these microbes conferring multi-drug resistance. The Principal Coordinate Analysis of the taxonomic composition of the Yamuna River water with publicly available freshwater and sewage datasets revealed significant differences in the two Yamuna samples and a greater resemblance of pre-monsoon Yamuna sample to sewage sample owing to the higher pollution levels in Yamuna in the pre-monsoon time.

Conclusion
The metagenomic study of the Yamuna river provides the first insights on the bacterial microbiome composition of this large polluted river, and also helps to understand the dynamics in the community structure and functions due to seasonal variations. The presence of antibiotic resistance genes and functional insights on the metabolic potential of a polluted river microbiome are likely to have several applications in health, biotechnology and bioremediation.
Pattern of fin rays along the antero-posterior axis based on their connection to distal radials
Authors: Hamada Hiroki , Uemoto Toshiaki , Tanaka Yoshitaka , Honda Yuki , Kitajima Keiichi , Umeda Tetsuya , Kawakami Atsushi , Shinya Minori , Kawakami Koichi , Tamura Koji , Abe Gembu 
Published: September 2019

AbstractBackgroundTeleost paired fins are composed of two endoskeletal domains, proximal and distal radials, and an exoskeletal domain, the fin ray. The zebrafish pectoral fin displays elaborately patterned radials along the anteroposterior (AP) axis. Radials are considered homologous to tetrapod limb skeletons, and their patterning mechanisms in embryonic development are similar to those of limb development. Nevertheless, the pattern along the AP axis in fin rays has not been well described in the zebrafish pectoral fin, although several recent reports have revealed that fin ray development shares some cellular and genetic properties with fin/limb endoskeleton development. Thus, fin ray morphogenesis may involve developmental mechanisms for AP patterning in the fin/limb endoskeleton, and may have a specific pattern along the AP axis.ResultsWe conducted detailed morphological observations on fin rays and their connection to distal radials by comparing intra- and inter-strain zebrafish specimens. Although the number of fin rays varied, pectoral fin rays could be categorized into three domains along the AP axis, according to the connection between the fin rays and distal radials; additionally, the number of fin rays varied in the posterior part of the three domains. This result was confirmed by observation of the morphogenesis process of fin rays and distal radials, which showed altered localization of distal radials in the middle domain. We also evaluated the expression pattern oflhxgenes, which have AP patterning activity in limb development, in fin rays and during distal radial development and found these genes to be expressed during morphogenesis in both fin rays and distal radials.ConclusionThe fin ray and its connection to the endoskeleton are patterned along the AP axis, and the pattern along the AP axis in the fin ray and the radial connection is constructed by the developmental mechanism related to AP patterning in the limb/fin bud. Our results indicate the possibility that the developmental mechanisms of fin rays and their connection are comparable to those of the distal element of the limb skeleton.
Large-scale narrative events in popular cinema
Authors: Cutting James E. , Armstrong Kacie L. 
Published: September 2019

Abstract
Most experiments in event perception and cognition have focused on events that are only a few minutes in length, and the previous research on popular movies is consistent with this temporal scope. Scenes are generally between a few seconds and a few minutes in duration. But popular movies also offer an opportunity to explore larger events—variously called acts, major parts, or large-scale parts by film theorists—in which the boundaries often have few if any unique physical attributes. These units tend to be between about 20 to 35 min in duration. The present study had observers watch seven movies they had not seen before and, over the course of several days and with ample justifications, reflect on them, and then segment them into two to six parts with the aid of a running description of the narrative. Results showed consistency across viewers’ segmentations, consistency with film-theoretic segmentations, and superiority over internet subjects who had access to only the scenarios used by the movie viewers. Thus, these results suggest that there are large scale events in movies; they support a view that their events are organized meronomically, layered with units of different sizes and with boundaries shared across layers; and they suggest that these larger-scale events can be discerned through cognitive, not perceptual, means.
Lower limb weakness with gyrus rectus hematoma: an unusual presentation of paraclinoid aneurysm; a case report with review of literature
Authors: Patankar Amey P. , Vaja Maulik 
Published: September 2019

AbstractLower limb weakness is usually a feature of ruptured anterior communicating (ACom) aneurysms due to spasm of the anterior cerebral arteries. Paraclinoid aneurysms, in addition to other cardinal features of subarachnoid haemorrhage (SAH), usually present with headache and visual field defects due to compression of the optic pathway. We report a case of left paraclinoid aneurysm presenting with right lower limb weakness and gyrus rectus hematoma without SAH. The aneurysm was long, passing beneath the optic nerve to emerge in the inter-optic cistern, leading to such atypical presentation. The aneurysm was clipped successfully after drilling the clinoid. As per our knowledge, such a clinical presentation of paraclinoid aneurysm has not been reported in the literature till date.
Effect of Psychological Intervention on Fear of Cancer Recurrence: A Systematic Review and Meta-Analysis
Authors: Tauber Nina M. , O’Toole Mia S. , Dinkel Andreas , Galica Jacqueline , Humphris Gerry , Lebel Sophie , Maheu Christine , Ozakinci Gozde , Prins Judith , Sharpe Louise , Smith Allan “Ben” , Thewes Belinda , Simard Sébastien , Zachariae Robert 
Published: September 2019

PURPOSEFear of cancer recurrence (FCR) is a significantly distressing problem that affects a substantial number of patients with and survivors of cancer; however, the overall efficacy of available psychological interventions on FCR remains unknown. We therefore evaluated this in the present systematic review and meta-analysis.METHODSWe searched key electronic databases to identify trials that evaluated the effect of psychological interventions on FCR among patients with and survivors of cancer. Controlled trials were subjected to meta-analysis, and the moderating influence of study characteristics on the effect were examined. Overall quality of evidence was evaluated using the GRADE system. Open trials were narratively reviewed to explore ongoing developments in the field (PROSPERO registration no.: CRD42017076514).RESULTSA total of 23 controlled trials (21 randomized controlled trials) and nine open trials were included. Small effects (Hedges’s g) were found both at postintervention ( g = 0.33; 95% CI, 0.20 to 0.46; P < .001) and at follow-up ( g = 0.28; 95% CI, 0.17 to 0.40; P < .001). Effects at postintervention of contemporary cognitive behavioral therapies (CBTs; g = 0.42) were larger than those of traditional CBTs ( g = 0.24; β = .22; 95% CI, .04 to .41; P = .018). At follow-up, larger effects were associated with shorter time to follow-up (β = −.01; 95% CI, −.01 to −.00; P = .027) and group-based formats (β = .18; 95% CI, .01 to .36; P = .041). A GRADE evaluation indicated evidence of moderate strength for effects of psychological intervention for FCR.CONCLUSIONPsychological interventions for FCR revealed a small but robust effect at postintervention, which was largely maintained at follow-up. Larger postintervention effects were found for contemporary CBTs that were focused on processes of cognition—for example, worry, rumination, and attentional bias—rather than the content, and aimed to change the way in which the individual relates to his or her inner experiences. Future trials could investigate how to further optimize and tailor interventions to individual patients’ FCR presentation.
Pembrolizumab in Relapsed and Refractory Mycosis Fungoides and Sézary Syndrome: A Multicenter Phase II Study
Authors: Khodadoust Michael S. , Rook Alain H. , Porcu Pierluigi , Foss Francine , Moskowitz Alison J. , Shustov Andrei , Shanbhag Satish , Sokol Lubomir , Fling Steven P. , Ramchurren Nirasha , Pierce Robert , Davis Asa , Shine Richard , Li Shufeng , Fong Sophia , Kim Jinah , Yang Yi , Blumenschein Wendy M. , Yearley Jennifer H. , Das Biswajit , Patidar Rajesh , Datta Vivekananda , Cantu Erin , McCutcheon Justine N. , Karlovich Chris , Williams P. Mickey , Subrahmanyam Priyanka B. , Maecker Holden T. , Horwitz Steven M. , Sharon Elad , Kohrt Holbrook E. , Cheever Martin A. , Kim Youn H. 
Published: September 2019

PURPOSE To assess the efficacy of pembrolizumab in patients with advanced relapsed or refractory mycosis fungoides (MF) or Sézary syndrome (SS). PATIENTS AND METHODS CITN-10 is a single-arm, multicenter phase II trial of 24 patients with advanced MF or SS. Patients were treated with pembrolizumab 2 mg/kg every 3 weeks for up to 24 months. The primary end point was overall response rate by consensus global response criteria. RESULTS Patients had advanced-stage disease (23 of 24 with stage IIB to IV MF/SS) and were heavily pretreated with a median of four prior systemic therapies. The overall response rate was 38% with two complete responses and seven partial responses. Of the nine responding patients, six had 90% or more improvement in skin disease by modified Severity Weighted Assessment Tool, and eight had ongoing responses at last follow-up. The median duration of response was not reached, with a median response follow-up time of 58 weeks. Immune-related adverse events led to treatment discontinuation in four patients. A transient worsening of erythroderma and pruritus occurred in 53% of patients with SS. This cutaneous flare reaction did not result in treatment discontinuation for any patient. The flare reaction correlated with high PD-1 expression on Sézary cells but did not associate with subsequent clinical responses or lack of response. Treatment responses did not correlate with expression of PD-L1, total mutation burden, or an interferon-γ gene expression signature. CONCLUSION Pembrolizumab demonstrated significant antitumor activity with durable responses and a favorable safety profile in patients with advanced MF/SS.
Invadopodia-mediated ECM degradation is enhanced in the G1 phase of the cell cycle
Authors: Bayarmagnai Battuya , Perrin Louisiane , Esmaeili Pourfarhangi Kamyar , Graña Xavier , Tüzel Erkan , Gligorijevic Bojana 
Published: September 2019

ABSTRACT
The process of tumor cell invasion and metastasis includes assembly of invadopodia, protrusions capable of degrading the extracellular matrix (ECM). The effect of cell cycle progression on invadopodia has not been elucidated. In this study, by using invadopodia and cell cycle fluorescent markers, we show in 2D and 3D cultures, as well as in vivo, that breast carcinoma cells assemble invadopodia and invade into the surrounding ECM preferentially during the G1 phase. The expression (MT1-MMP, also known as MMP14, and cortactin) and localization (Tks5; also known as SH3PXD2A) of invadopodia components are elevated in G1 phase, and cells synchronized in G1 phase exhibit significantly higher ECM degradation compared to the cells synchronized in S phase. The cyclin-dependent kinase inhibitor (CKI) p27kip1 (also known as CDKN1B) localizes to the sites of invadopodia assembly. Overexpression and stable knockdown of p27kip1 lead to contrasting effects on invadopodia turnover and ECM degradation. Taken together, these findings suggest that expression of invadopodia components, as well as invadopodia function, are linked to cell cycle progression, and that invadopodia are controlled by cell cycle regulators. Our results caution that this coordination between invasion and cell cycle must be considered when designing effective chemotherapies.
Impact of movement and motion-artefact correction on image quality and interpretability in CBCT units with aligned and lateral-offset detectors
Authors: Santaella Gustavo Machado , Wenzel Ann , Haiter-Neto Francisco , Rosalen Pedro Luiz , Spin-Neto Rubens 
Published: September 2019

Objectives: To evaluate the impact of movement and motion-artefact correction systems on CBCT image quality and interpretability of simulated diagnostic tasks for aligned and lateral-offset detectors. Methods: A human skull simulating three diagnostic tasks (implant planning in the anterior maxilla, implant planning in the left-side-mandible and mandibular molar furcation assessment in the right-side-mandible) was mounted on a robot performing six movement types. Four CBCT units were used: Cranex 3Dx (CRA), Ortophos SL (ORT), Promax 3D Mid (PRO), and X1. Protocols were tested with aligned (CRA, ORT, PRO, and X1) and lateral-offset (CRA and PRO) detectors and two motion-artefact correction systems (PRO and X1). Movements were performed at one moment-in-time (t1), for units with an aligned detector, and three moments-in-time (t1-first-half of the acquisition, t2-second-half, t3-both) for the units with a lateral-offset detector. 98 volumes were acquired. Images were scored by three observers, blinded to the unit and presence of movement, for motion-related stripe artefacts, overall unsharpness, and interpretability. Fleiss’ κ was used to assess interobserver agreement. Results: Interobserver agreement was substantial for all parameters (0.66–0.68). For aligned detectors, in all diagnostic tasks a motion-artefact correction system influenced image interpretability. For lateral-offset detectors, the interpretability varied according to the unit and moment-in-time, in which the movement was performed. PRO motion-artefact correction system was less effective for the offset detector than its aligned counterpart. Conclusion: Motion-artefact correction systems enhanced image quality and interpretability for units with aligned detectors but were less effective for those with lateral-offset detectors.
Procedural Justice and the Risks of Consumer Voting
Authors: Kim Tami , John Leslie K. , Rogers Todd , Norton Michael I. 
Published: September 2019

Firms are increasingly giving consumers the vote. Eight studies show that, when firms empower consumers to vote, consumers infer a series of implicit promises—even in the absence of explicit promises. We identify three implicit promises to which consumers react negatively when violated: representation (Experiments 1A–1C), consistency (Experiment 2), and nonsuppression (Experiment 3). However, when firms honor these implicit promises, voting can mitigate the disappointment that arises from receiving an undesired outcome (Experiment 4). Finally, Experiment 5 identifies one instance when suppressing the vote outcome is condoned: when voters believe that the process of voting has resulted in an unacceptable outcome. More generally, we show that procedural justice plays a key mediating role in determining the relative success or failure of various empowerment initiatives—from soliciting feedback to voting. Taken together, we offer insight into how firms can realize the benefits of empowerment strategies while mitigating their risks. This paper was accepted by Elke Weber, judgment and decision making.
Importance of establishment of corporate culture in libraries in the development of information services
Authors: Bayter Mustafa 
Published: September 2019

Institutions carry the reflections of the culture in which they are formed. Therefore, each institution is influenced by its cultural structure in order to create its own culture. This corporate culture consists of values, beliefs and norms that hold the members of the institution together. Libraries are the institutions with the most important sources of information. The longer the corporate culture is established within this organization, the more effective the access to information and communication with the user will be. In this context, the subject of our study, the definition and history of corporate culture, the formation of corporate culture, the place and importance of culture in the institution, the elements of corporate culture, corporate culture and corporate change, corporate culture and management, the effect of managers in the formation of corporate culture, corporate culture and human resources, corporate culture culture and institutional commitment, the formation of institutional culture in the library institution, library and institutional behavior, library and institutional culture, the effect of the library on the formation of corporate culture. ​Extended English summary is in the end of Full Text PDF (TURKISH) file. Özet Kurumlar, içinde oluştukları kültürün yansımalarını taşırlar. Bu yüzden her kurum kendi kültürünü oluşturabilmek için içinde bulunduğu kültür yapısından etkilenmektedir. Kurumsal kültür, kurum üyelerini bir arada tutan değerler, inanç, normlardan meydana gelmektedir. Kütüphaneler bilgi aktarımını sağlayan en önemli bilgi kaynaklarına sahip kurumlardır. Kütüphane kurumu içerisinde kurum kültürü ne kadar iyi oluşursa bilgiye ulaşım ve kullanıcı ile olan iletişim o kadar etkili olacaktır. Bu çalışmada bilgi hizmetlerinin gelişmesinde kütüphanelerde kurum kültürünün oluşmasının önemi, kurum kültürünün tanımı ve tarihçesi, kurumsal kültürün oluşması, kültürün kurumdaki yeri ve önemi, kurum kültürünü oluşturan unsurlar, kurum kültürü ve kurumsal değişim, kurum kültürü ve yönetim, kurum kültürünün oluşmasında yöneticilerin etkisi, kurum kültürü ve insan kaynakları, kurum kültürü ve kurumsal bağlılık, kütüphane kurumunda kurumsal kültürün oluşumu, kütüphane ve kurumsal davranış, kütüphane ve kurum kültürü, kütüphanenin kurum kültürü oluşturmasındaki etkisi başlıkları altında incelenmeye çalışılmıştır.
PrivateSQL
Authors: Kotsogiannis Ios , Tao Yuchao , He Xi , Fanaeepour Maryam , Machanavajjhala Ashwin , Hay Michael , Miklau Gerome 
Published: September 2019

Differential privacy is considered a de facto standard for private data analysis. However, the definition and much of the supporting literature applies to flat tables. While there exist variants of the definition and specialized algorithms for specific types of relational data (e.g. graphs), there isn't a general privacy definition for multi-relational schemas with constraints, and no system that permits accurate differentially private answering of SQL queries while imposing a fixed privacy budget across all queries posed by the analyst.
This work presents PrivateSQL, a first-of-its-kind end-to-end differentially private relational database system. PrivateSQL allows an analyst to query data stored in a standard database management system using a rich class of SQL counting queries. PrivateSQL adopts a novel generalization of differential privacy to multi-relational data that takes into account constraints in the schema like foreign keys, and allows the data owner to flexibly specify entities in the schema that need privacy. PrivateSQL ensures a fixed privacy loss across all the queries posed by the analyst by answering queries on private synopses generated from several views over the base relation that are tuned to have low error on a representative query workload. We experimentally evaluate PrivateSQL on a real-world dataset and a workload of more than 3, 600 queries. We show that for 50% of the queries PrivateSQL offers at least 1, 000x better error rates than solutions adapted from prior work.