bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-Dimensional Structure of Mass-Weighted Isentropic Time-Mean Meridional Circulations
Authors: Kanno Yuki , Iwasaki Toshiki 
Published: April 2018

Abstract
The present study develops a diagnostic framework for investigating the three-dimensional (3D) structure of mass-weighted isentropic time-mean (T-MIM) meridional circulations and conducts a preliminary analysis of the winter hemispheres. The T-MIM meridional velocity can unfold, in the zonal direction, time-averaged two-dimensional (2D) mass-weighted isentropic zonal means. Furthermore, the T-MIM velocity can be decomposed into the unweighted isentropic time-mean (uTM) velocity and the temporal eddy-correlated transport velocity, the so-called bolus velocity. The bolus velocity greatly contributes to the 2D extratropical direct circulation in the troposphere and to the Brewer–Dobson circulation in the stratosphere. The 3D bolus velocity seems to reflect the geographical distributions of baroclinic instability wave activity. In the boreal winter, both low-level equatorward flows and upper-level poleward flows are located around the North Pacific and North Atlantic storm tracks. In the austral winter, low-level equatorward flows extend zonally across the midlatitudes. In the subtropics, the 3D bolus velocity is found to be significant in the upper branch of the Hadley circulation. A zonal momentum equation is formulated to examine the 3D momentum balance of the meridional circulation in the T-MIM framework. In the extratropics, the uTM and bolus meridional velocities are in geostrophic balance with the stationary and transient components of the 3D Eliassen–Palm (EP) flux divergence, respectively. The pressure gradient force of transient baroclinic instability waves balances with the low-level equatorward flows of the bolus velocity in the storm tracks.
Theoretical Analysis of the Entrainment–Mixing Process at Cloud Boundaries. Part I: Droplet Size Distributions and Humidity within the Interface Zone
Authors: Pinsky Mark , Khain Alexander 
Published: April 2018

Abstract
The problem of a complex entrainment–mixing process is analyzed by solving a diffusion–evaporation equation for an open region in the vicinity of the cloud–dry air interface. Upon normalization the problem is reduced to a one-parametric one, the governing parameter being the potential evaporation parameter R proportional to the ratio of saturation deficit in the dry air to the available liquid water content in the cloud air. As distinct from previous multiple studies analyzing mixing within closed adiabatic volumes, we consider a principally nonstationary problem that never leads to a homogeneous equilibrium state. It is shown that at R &lt; −1 the cloud edge shifts toward the cloud; that is, the cloud dissipates due to mixing with dry air, and the cloud volume decreases. If R &gt; −1, the cloud edge shifts outside; that is, the mixing leads to an increase in the cloud volume. The time evolution of droplet size distribution and its moments, as well as the relative humidity within the expanding cloud–dry air interface, are calculated and analyzed. It is shown that the values of the mean volume radii rapidly decrease within the interface zone in the direction away from the cloud, indicating significant changes in the cloud edge microstructure. Scattering diagrams plotted for the cloud edge agree well with high-frequency in situ measurements, corroborating the reliability of the proposed approach. It is shown that the humidity front moves toward dry air faster than the front of liquid water content. As a result, the mixing leads to formation of a humid air shell around the cloud. The widths of the interface zone and humid shell are evaluated.
Rossby Wave Packets on the Midlatitude Waveguide—A Review
Authors: Wirth Volkmar , Riemer Michael , Chang Edmund K. M. , Martius Olivia 
Published: April 2018

AbstractRossby wave packets (RWPs) are Rossby waves for which the amplitude has a local maximum and decays to smaller values at larger distances. This review focuses on upper-tropospheric transient RWPs along the midlatitude jet stream. Their central characteristic is the propagation in the zonal direction as well as the transfer of wave energy from one individual trough or ridge to its downstream neighbor, a process called “downstream development.” These RWPs sometimes act as long-range precursors to extreme weather and presumably have an influence on the predictability of midlatitude weather systems. The paper reviews research progress in this area with an emphasis on developments during the last 15 years. The current state of knowledge is summarized including a discussion of the RWP life cycle as well as Rossby waveguides. Recent progress in the dynamical understanding of RWPs has been based, in part, on the development of diagnostic methods. These methods include algorithms to identify and track RWPs in an automated manner, which can be used to extract the climatological properties of RWPs. RWP dynamics have traditionally been investigated using the eddy kinetic energy framework; alternative approaches based on potential vorticity and wave activity fluxes are discussed and put into perspective with the more traditional approach. The different diagnostics are compared to each other and the strengths and weaknesses of individual methods are highlighted. A recurrent theme is the role of diabatic processes, which can be a source for forecast errors. Finally, the paper points to important open research questions and suggests avenues for future research.
Anatomical and radiologic characteristics of isthmus parameters in guiding pedicle screw placement
Authors: Rexiti Paerhati , Abulizi Yakufu , Muheremu Aikeremujiang , Wang Shuiquan , Maimaiti Maierdan , Guo Hailong , Sheng Weibin 
Published: April 2018

Objective To study the clinical application of lumbar isthmus parameters in guiding pedicle screw placement. Methods Lumbar isthmus parameters were measured in normal lumbar x-rays and cadaveric specimens from a Chinese Han population. Distance between the medial pedicle border and lateral isthmus border was recorded as a ‘D’ value and was compared between X-rays and cadavers. Orthopaedic surgeons estimated different distances (2–6 mm) and angles (5–20°), and bias ratios between estimated and real values were compared. Orthopaedic residents placed pedicle screws on cadaveric specimens before and after application of the ‘D’ value, and screw placement accuracy was compared. Results Except for L4 vertebrae, significant differences in the ‘D’ value were found between 25 cadaveric specimens and x-ray films from 120 patients. Distances and angles estimated by 40 surgeons were significantly different from all real values, except 2 mm distance. Accuracy of pedicle screw placement by six orthopaedic residents was significantly improved by applying the ‘D’ value. Conclusions Surgeon estimates of distance were more accurate than angle estimates. Addition of a ‘D’ value to conventional parameters may significantly improve pedicle screw placement accuracy in lumbar spine surgery.
A new and intuitive test for zero modification
Authors: Wilson Paul , Einbeck Jochen 
Published: April 2018

Abstract: While there do exist several statistical tests for detecting zero modification in count data regression models, these rely on asymptotical results and do not transparently distinguish between zero inflation and zero deflation. In this manuscript, a novel non-asymptotic test is introduced which makes direct use of the fact that the distribution of the number of zeros under the null hypothesis of no zero modification can be described by a Poisson-binomial distribution. The computation of critical values from this distribution requires estimation of the mean parameter under the null hypothesis, for which a hybrid estimator involving a zero-truncated mean estimator is proposed. Power and nominal level attainment rates of the new test are studied, which turn out to be very competitive to those of the likelihood ratio test. Illustrative data examples are provided.
Quality Control of Norwegian Pharmacy HbA1c Testing: A Modest Beginning
Authors: Ørvim Sølvik Una , Risøy Aslaug Johanne , Kjome Reidun L. S. , Sandberg Sverre 
Published: April 2018

Background: Many pharmacy services involve laboratory testing using point-of-care (POC) instruments. Our aim was to describe the implementation of quality control of the HbA1c POC instruments and investigate the performance in internal quality control (IQC) and external quality control (EQA) for HbA1c POC instruments in Norwegian community pharmacies. Methods: Two project pharmacists from each of 11 pharmacies participated in a training program covering capillary blood sampling, how to use the POC HbA1c instrument (DCA Vantage) and IQC and EQA. The pharmacies were enrolled in an EQA program for HbA1c, and their performance was compared with that of general practitioners’ (GP) offices. Results: Two of 89 (2.2%) IQC measurements were outside the acceptance interval. Seven out of 11 pharmacies sent in results in EQA in all the three surveys during six months. Two pharmacies did not analyze the control material in any of the surveys, one pharmacy analyzed the control material in one of the surveys, and one pharmacy analyzed two of the surveys. Of these pharmacies, 56-100% obtained “very good” evaluation for trueness and 71-100% obtained “very good” evaluation for precision. The corresponding numbers for GP offices were 75-87% for trueness and 84-94% for precision. No pharmacies obtained a “poor” evaluation. Conclusions: Norwegian community pharmacies can perform IQC and EQA on a HbA1c POC instrument, and the performance is comparable with that of GP offices. The compliance in the EQA surveys was modest, but the duration of the study and participation in the EQA program was probably too short to implement all the new procedures for all pharmacies.
Systematic Theology and Spiritual Formation: Recovering Obscured Unities
Authors: Graham Jeannine Michele 
Published: April 2018

“For this reason, since the day we heard about you, we have not stopped praying for you. We continually ask God to fill you with the knowledge of his will through all the wisdom and understanding that the Spirit gives, so that you may live a life worthy of the Lord and please him in every way: bearing fruit in every good work, growing in the knowledge of God, being strengthened with all power according to his glorious might so that you may have great endurance and patience, and giving joyful thanks to the Father, who has qualified you to share in the inheritance of his holy people in the kingdom of light. For he has rescued us from the dominion of darkness and brought us into the kingdom of the Son he loves, in whom we have redemption, the forgiveness of sins.” (Colossians 1:9-14) “And this is my prayer: that your love may abound more and more in knowledge and depth of insight, so that you may be able to discern what is best and may be pure and blameless for the day of Christ, filled with the fruit of righteousness that comes through Jesus Christ–-to the glory and praise of God.” (Philippians 1:9–11)1
14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling
Authors: Chen Yunfeng , Ruggeri Zaverio M. , Du Xiaoping 
Published: April 2018

AbstractMembers of the 14-3-3 family of proteins function as adapters/modulators that recognize phosphoserine/phosphothreonine-based binding motifs in many intracellular proteins and play fundamental roles in signal transduction pathways of eukaryotic cells. In platelets, 14-3-3 plays a wide range of regulatory roles in phosphorylation-dependent signaling pathways, including G-protein signaling, cAMP signaling, agonist-induced phosphatidylserine exposure, and regulation of mitochondrial function. In particular, 14-3-3 interacts with several phosphoserine-dependent binding sites in the major platelet adhesion receptor, the glycoprotein Ib-IX complex (GPIb-IX), regulating its interaction with von Willebrand factor (VWF) and mediating VWF/GPIb-IX–dependent mechanosignal transduction, leading to platelet activation. The interaction of 14-3-3 with GPIb-IX also plays a critical role in enabling the platelet response to low concentrations of thrombin through cooperative signaling mediated by protease-activated receptors and GPIb-IX. The various functions of 14-3-3 in platelets suggest that it is a possible target for the treatment of thrombosis and inflammation.
Biomarkers for posttransplantation outcomes
Authors: Paczesny Sophie 
Published: April 2018

AbstractDuring the last decade, the development of biomarkers for the complications seen after allogeneic hematopoietic stem cell transplantation has expanded tremendously, with the most progress having been made for acute graft-versus-host disease (aGVHD), a common and often fatal complication. Although many factors are known to determine transplant outcome (including the age of the recipient, comorbidity, conditioning intensity, donor source, donor-recipient HLA compatibility, conditioning regimen, posttransplant GVHD prophylaxis), they are incomplete guides for predicting outcomes. Thanks to the advances in genomics, transcriptomics, proteomics, and cytomics technologies, blood biomarkers have been identified and validated for us in promising diagnostic tests, prognostic tests stratifying for future occurrence of aGVHD, and predictive tests for responsiveness to GVHD therapy and nonrelapse mortality. These biomarkers may facilitate timely and selective therapeutic intervention. However, such blood tests are not yet available for routine clinical care. This article provides an overview of the candidate biomarkers for clinical evaluation and outlines a path from biomarker discovery to first clinical correlation, to validation in independent cohorts, to a biomarker-based clinical trial, and finally to general clinical application. This article focuses on biomarkers discovered with a large-scale proteomics platform and validated with the same reproducible assay in at least 2 independent cohorts with sufficient sample size according to the 2014 National Institutes of Health consensus on biomarker criteria, as well as on biomarkers as tests for risk stratification of outcomes, but not on their pathophysiologic contributions, which have been reviewed recently.
Impact of age and comorbidity on risk stratification in idiopathic pulmonary arterial hypertension
Authors: Hjalmarsson Clara , Rådegran Göran , Kylhammar David , Rundqvist Bengt , Multing Jonas , Nisell Magnus D. , Kjellström Barbro 
Published: April 2018

Recent reports from worldwide pulmonary hypertension registries show a new demographic picture for patients with idiopathic pulmonary arterial hypertension (IPAH), with an increasing prevalence among the elderly.We aimed to investigate the effects of age and comorbidity on risk stratification and outcome of patients with incident IPAH.The study population (n=264) was categorised into four age groups: 18–45, 46–64, 65–74 and ≥75 years. Individual risk profiles were determined according to a risk assessment instrument, based on the European Society of Cardiology and the European Respiratory Society guidelines. The change in risk group from baseline to follow-up (median 5 months) and survival were compared across age groups. In the two youngest age groups, a significant number of patients improved (18–45 years, Z= −4.613, p<0.001; 46–64 years, Z= −2.125, p=0.034), but no significant improvement was found in the older patient groups. 5-year survival was highest in patients aged 18–45 years (88%), while the survival rates were 63%, 56% and 36% for patients in the groups 46–64, 65–74 and ≥75 years, respectively (p<0.001). Ischaemic heart disease and kidney dysfunction independently predicted survival.These findings highlight the importance of age and specific comorbidities as prognostic markers of outcome in addition to established risk assessment algorithms.
Three Versus 6 Months of Oxaliplatin-Based Adjuvant Chemotherapy for Patients With Stage III Colon Cancer: Disease-Free Survival Results From a Randomized, Open-Label, International Duration Evaluation of Adjuvant (IDEA) France, Phase III Trial
Authors: André Thierry , Vernerey Dewi , Mineur Laurent , Bennouna Jaafar , Desrame Jérôme , Faroux Roger , Fratte Serge , Hug de Larauze Marine , Paget-Bailly Sophie , Chibaudel Benoist , Bez Jeremie , Dauba Jérôme , Louvet Christophe , Lepere Céline , Dupuis Olivier , Becouarn Yves , Mabro May , Egreteau Joëlle , Bouche Olivier , Deplanque Gaël , Ychou Marc , Galais Marie Pierre , Ghiringhelli François , Dourthe Louis Marie , Bachet Jean-Baptiste , Khalil Ahmed , Bonnetain Franck , de Gramont Aimery , Taieb Julien ,   for PRODIGE investigators, GERCOR, Fédération Française de Cancérologie Digestive, and UNICANCER
Published: April 2018

Purpose Reduction of adjuvant treatment duration may decrease toxicities without loss of efficacy in stage III colon cancer. This could offer clear advantages to patients and health care providers. Methods In International Duration Evaluation of Adjuvant Chemotherapy (IDEA) France, as part of the IDEA international collaboration, patient with colon cancer patients were randomly assigned to 3 and 6 months of modified FOLFOX6 (mFOLFOX6: infusional fluorouracil, leucovorin, and oxaliplatin) or capecitabine plus oxaliplatin (CAPOX) by physician choice. The primary end point was disease-free survival (DFS), and analyses were descriptive. Results A total of 2,010 eligible patients received either 3 or 6 months of chemotherapy (modified intention-to-treat population); 2,000 (99%) had stage III colon cancer (N1: 75%, N2: 25%); 1,809 (90%) received mFOLFOX6, and 201 (10%) received CAPOX. The median age was 64 years, and the median follow-up time was 4.3 years. Overall, 94% (3 months) and 78% (6 months) of patients completed treatment (fluoropyrimidines ± oxaliplatin). Maximal grade 2 and 3 neuropathy rates were 28% and 8% in the 3-month arm and 41% and 25% in the 6-month arm ( P < .001). Final rates of residual neuropathy greater than grade 1 were 3% in the 3-month arm and 7% in the 6-month arm ( P < .001). There were 578 DFS events: 314 and 264 in the 3- and 6-month arms, respectively. The 3-year DFS rates were 72% and 76% in the 3- and 6-month arms, respectively (hazard ratio [HR], 1.24; 95% CI, 1.05 to 1.46; P = .0112). In the 3 and 6-month arms, respectively, for patients who received mFOLFOX6, the 3-year DFS rates were 72% and 76% (HR, 1.27; 95% CI, 1.07 to 1.51); for the T4 and/or N2 population, they were 58% and 66% (HR, 1.44; 95% CI, 1.14 to 1.82); and for the T1-3N1 population, they were 81% and 83% (HR, 1.15; 95% CI, 0.89 to 1.49). Conclusion IDEA France, in which 90% of patients received mFOLFOX6, shows superiority of 6 months of adjuvant chemotherapy compared with 3 months, especially in the T4 and/or N2 subgroups. These results should be considered alongside the international IDEA collaboration data.
FOLFOX or CAPOX in Stage II to III Colon Cancer: Efficacy Results of the Italian Three or Six Colon Adjuvant Trial
Authors: Sobrero Alberto , Lonardi Sara , Rosati Gerardo , Di Bartolomeo Maria , Ronzoni Monica , Pella Nicoletta , Scartozzi Mario , Banzi Maria , Zampino Maria Giulia , Pasini Felice , Marchetti Paolo , Cantore Maurizio , Zaniboni Alberto , Rimassa Lorenza , Ciuffreda Libero , Ferrari Daris , Zagonel Vittorina , Maiello Evaristo , Barni Sandro , Rulli Eliana , Labianca Roberto ,   on behalf of the TOSCA Investigators
Published: April 2018

Purpose Given the cumulative neurotoxicity associated with oxaliplatin, a shorter duration of adjuvant therapy, if equally efficacious, would be advantageous for patients and health-care systems. Methods The Three or Six Colon Adjuvant trial is an open-label, phase III, multicenter, noninferiority trial randomizing patients with high-risk stage II or stage III colon cancer to receive 3 months or 6 months of FOLFOX (fluorouracil, leucovorin, and oxaliplatin) or CAPOX (capecitabine plus oxaliplatin). Primary end-point is relapse-free survival. Results 3,759 patients were accrued from 130 Italian sites, 64% receiving FOLFOX and 36% CAPOX. Two-thirds were stage III. The median time of follow up was 62 months and 772 relapses or deaths have been observed. The hazard ratio (HR) of the 3 months versus 6 months for relapse/death was 1.14 (95% CI, 0.99 to 1.32; P [for noninferiority] = .514) and the CI crossed the noninferiority limit of 1.20. However, the absolute difference in 3-year RFS was 1.9% (95% CI, -0.7% to 4.4%). Counter-intuitively, while the RFS curves were similar for stage III (HR, 1.07; 95% CI, 0.91 to 1.26) and for CAPOX treated patients (HR, 0.98; 95% CI, 0.77 to 1.26), they were not for stage II and for FOLFOX treated patients, with HR of 1.41 (95% CI, 1.05 to 1.89) and 1.23 (95% CI, 1.03 to 1.46), respectively, favoring the 6 months of treatment. Conclusion The Three or Six Colon Adjuvant trial failed to formally show noninferiority of 3 versus 6 months of treatment to the predefined margin of 20% relative increase. The results depended on the adjuvant regimen and risk. For CAPOX, 3 months were as good as 6 months; for FOLFOX, 6 months added extra benefit. Counter-intuitively, the low-risk patients benefitted more than the high-risk population from the 6-month duration. The choice of regimen and duration should depend on patient characteristics and be balanced against the extra toxicity of longer therapy.
Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes
Authors: Hoch-Kraft Peter , White Robin , Tenzer Stefan , Krämer-Albers Eva-Maria , Trotter Jacqueline , Gonsior Constantin 
Published: April 2018

ABSTRACT
In the central nervous system, oligodendroglial expression of myelin basic protein (MBP) is crucial for the assembly and structure of the myelin sheath. MBP synthesis is tightly regulated in space and time, particularly at the post-transcriptional level. We have identified the DEAD-box RNA helicase DDX5 (also known as p68) in a complex with Mbp mRNA in oligodendroglial cells. Expression of DDX5 is highest in progenitor cells and immature oligodendrocytes, where it localizes to heterogeneous populations of cytoplasmic ribonucleoprotein (RNP) complexes associated with Mbp mRNA in the cell body and processes. Manipulation of the amount of DDX5 protein inversely affects the level of MBP. We present evidence that DDX5 is involved in post-transcriptional regulation of MBP protein synthesis, with implications for oligodendroglial development. In addition, knockdown of DDX5 results in an increased abundance of MBP isoforms containing exon 2 in immature oligodendrocytes, most likely by regulating alternative splicing of Mbp. Our findings contribute to the understanding of the complex nature of MBP post-transcriptional control in immature oligodendrocytes where DDX5 appears to affect the abundance of MBP proteins via distinct but converging mechanisms.
Crise cambial: riscos e oportunidades
Authors: Biderman Ciro 
Published: April 2018

A análise das semelhanças e diferenças entre a crise cambial de 1999 e a iniciada no segundo semestre de 2002 pode resultar em uma ferramenta preciosa para a identificação dos riscos e das oportunidades que se seguirão a seu desfecho. Ao que tudo indica, os setores que utilizam insumos domésticos encontrarão um cenário mais favorável que aqueles dependentes de insumos denominados em moeda estrangeira com vendas para o mercado interno brasileiro.
Tropeços colaborativos
Authors: Kujawski Guilherme 
Published: April 2018

Uma nova safra de ferramentas de cooperação está invadindo escritórios e modificando a tradicional cultura corporativa fundamentada na competição. Do já conhecido correio eletrônico a ferramentas que prometem verdadeiras jam sessions entre grupos de trabalho, os modernos recursos de colaboração prometem uma nova era ao ambiente empresarial. Mas será que a tecnologia sozinha pode resolver todos os problemas humanos das organizações, como crises de relacionamento e resistências ao trabalho em equipe?