bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Health-Related Quality of Life in Patients with Dry Eye Syndrome Classified by Severity and Causes Including the Autoimmune and Non-autoimmune Diseases: A Cross-sectional Study in Thailand
Authors: Towiwat Patapong , Tantichariyangkul Phattharaphong , Dilokthornsakul Piyameth , Khotcharrat Rossukon , Sawatdiwithayayong Jeerawat , Bhoopat Taniya , Upakdee Nilawan 
Published: November 2024

Background: The common causes of Dry eye syndrome (DES) were autoimmune or non-autoimmune disorders. DES is common but lack of data in quality of life (QoL) of DES patients in Thailand. The primary outcome of this study was to determine QoL and health utility in patients of DES by EuroQol 5-domain (EQ-5D) of the 5-level version (5L) instrument. The secondary outcome was comparison of the utility in the patients of DES classified by severity and causes including the autoimmune and non-autoimmune diseases. Methods: The study was a cross-sectional study at a hospital in the northern part of Thailand. The inclusions DES patients were followed by Tear Film and Ocular surface Society the Dry Eye WorkShop II definition. The EQ-5D-5L (Thai version) descriptive system and the EQ visual analogue scale (VAS) was instrument for QoL evaluation. Results: Total patients of DES were fifty-six. The most patients were female. The mean age was 57.7(± 13.9) years. Most patients (94.6%) were female. The mean age was 59.7 (± 13.9) years old. The median time from diagnosis of DES was 4.7 years (IQR = 2.2 to 6.8 years). The common cause of DES associated was autoimmune disease. Primary Sjogren syndrome and idiopathic causes were the most common causes in autoimmune diseases and non- autoimmune diseases, respectively. In autoimmune disease, Primary Sjogren syndrome, was 41.18%. The most common causes of non-autoimmune diseases were idiopathic. The mean of EQ-5D-utility and EQ-VAS of DES were 0.76 (± 0.18) and 72.86 (± 15.19), respectively. The mean of EQ-5D-utility and EQ-VAS in these patients who were classified by severity including mild, moderate and severe were 0.84 (± 0.16) and 67.31(± 15.76), 0.78 (± 0.14) and 74.47 (± 15.71), 0.71 (± 0.22) and 74.58 (± 14.36), respectively. The mean of EQ-5D-utility and EQ-VAS in these patients who were classified by autoimmune or non-autoimmune disorders were 0.75 (± 0.21) and 75.78 (± 14.21), 0.78 (± 0.15) and 68.96 (± 15.88), respectively. There is no statistic significant in the EQ-5D-utility and EQ-VAS among severity and the causes including autoimmune or non-autoimmune disorders of these patients. Conclusions: This study demonstrated the importance of assessing QoL in DES. Primary Sjogren syndrome and idiopathic causes were the most common causes in autoimmune diseases and non-autoimmune diseases, respectively. The EQ-5D-utility was accorded with the severity of DES. However, no statistic significant was showed in the mean of EQ-5D-utility and EQ-VAS between the severity and between the causes including the autoimmune and non-autoimmune diseases of these patients.
Audit on Skin and Quality of Life Assessment of Psoriatic Arthritis
Authors: De Silva Suren William , Chathraikkal Shanoj , Cheung Annie , Brockbank John 
Published: November 2024

Background Skin involvement in PsA is associated with worsened overall health related quality of life, increased health care utilisation. Skin disease is assessed objectively through PASI score. As per BSR guidelines for treatment of PsA, skin and quality of life (QOL) assessment is an important domain in deciding escalation of treatment for biologics. Assessment of skin aids in selection of the type of biologic. Methods 20 patients with psoriatic arthritis were assessed in rheumatology outpatient clinics of East Lancashire Hospitals NHS trust, UK. The last letter to GP of each patient was reviewed. Data on objective assessment (PASI Score) and subjective assessment (mild, moderate or severe) or no assessment of skin disease along with QOL assessment was recorded. Staff were educated to assess PASI score, using mobile application “GRAPPA”, calculate and document. All patients with psoriatic arthritis were given the Dermatology Life Quality Index (DLQI) questionnaire. BSR 2022 guidance on PsA was considered as the standard reference.  After 3 months of intervention, data were analysed the effectiveness of the intervention. Results Pre intervention results showed a subjective assessment of 10 (50%), Objective assessment of skin disease 0(0%), and DLQI assessment of 0 (0%). Post intervention results showed an improvement of objective assessment of skin via PASI score to 10 (50%). Another 8 (40%) of patients had subjective assessment of skin. DLQI assessment improved to 4(20%). Conclusion Introduction of convenient mobile application to assess skin involvement of PsA had shown remarkable improvement of PASI score. DQOLI patient questionnaire improved QOL assessment in PsA patients.  Change of practice through objective skin assessment through PASI score and assessment of DQOLI lead to escalation of treatment to biologics. In addition, PASI score helped in selection of most appropriate biologic that targets both skin and joints.
Risk Factors of In‐Hospital Venous Thromboembolism and Prognosis After Emergent Ventral Hernia Repair
Authors: Yang Wei , Ling Jie , Zhou Yun , Yang Pengcheng , Chen Jiejing 
Published: November 2024

Background: The risk factors and association of venous thromboembolism (VTE) following emergent ventral hernia repair (EVHR) remains uncertain. This aim of the study aims was to establish the predictors of VTE after EVHR and its influence on the long‐term outcomes.Methods: A total of 2093 patients from the MIMIC‐IV database who underwent EVHR were recruited. Multivariate logistic regression and nomogram models were developed to predict in‐hospital VTE and mortality. Calibration and receiver operating characteristic (ROC) curves were utilized to assess the model’s effectiveness and reliability. Decision curve analysis (DCA) was performed to evaluate the net clinical benefits of the model.Results: The rate of in‐hospital VTE was 1.6% (33/2093) after EVHR. Four independent potential factors were established after multivariate analysis, and the abovementioned risk factors fit into the nomogram. The prediction model presented good performance metrics (C‐index: 0.857), the calibration and ROC curves demonstrated the accurate prediction power, and DCA indicated the superior net benefit of the established model. In‐hospital and 1‐year mortality rates were 0.8% (17/2093) and 4.1% (86/2076) after EVHR. The potential factors were included in the mortality prediction nomogram. The prediction model presented good performance metrics (C‐index of 0.957 and 0.828, respectively), the calibration and ROC curves were consistent with the actual results, and DCA indicated the superior net benefit of the established model.Conclusion: The nomogram, derived from the logistic regression model, demonstrated excellent predictive performance for VTE occurrence and prognosis in patients following EVHR. This model could serve as a valuable reference for clinical decision‐making regarding VTE prevention and for enhancing post‐EVHR prognosis.
An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer
Authors: Bae Tae Hyun , Sung Ki Woon , Pham Tri M. , Najy Abdo J. , Zamiri Alaleh , Jang Hyejeong , Mun Su Ran , Kim Seongho , Kwon Ha Kyoung , Son Yeon Sung , Shi Dongping , Kregel Steven , Heath Elisabeth I. , Cher Michael L. , Kwon Yong Tae , Kim Hyeong-Reh Choi 
Published: November 2024

Abstract
Genetic alterations play a pivotal role in various human diseases, particularly cancer. The androgen receptor (AR) is a crucial transcription factor driving prostate cancer progression across all stages. Current AR-targeting therapies utilize competitive AR antagonists or pathway suppressors. However, therapy resistance often emerges due to AR mutations and AR splice variants, such as AR-v7. To overcome this, we developed ATC-324, an AR degrader using the innovative protein degradation technology platform AUTOphagy-TArgeting Chimera (AUTOTAC). ATC-324 was designed to comprise enzalutamide, an AR inhibitor, as a target-binding ligand and YT 6-2, a ligand of the autophagy receptor p62/SQSTM1, as an autophagy-targeting ligand. ATC-324 induces the formation of the AR/p62 complex, leading to autophagy–lysosomal degradation of AR. Importantly, ATC-324 effectively degrades AR mutants frequently detected in prostate cancer and codegrades AR-v7 as a heterodimer with full-length AR. ATC-324 reduces nuclear AR levels and downregulates the target gene expression of AR and AR-v7, leading to cytotoxicity in AR-positive prostate cancer cells. We also provide evidence of the therapeutic potential of ATC-324 in vivo as well as ex vivo bone organ culture. Moreover, ATC-324 remains potent in enzalutamide-resistant prostate cancer cells. These results demonstrate the potential of the AUTOTAC platform to target previously considered undruggable proteins and overcome certain drug resistance mechanisms.
Significance: The characterization of an AUTOTAC-based degrader capable of inducing autophagic degradation of wild-type and mutated androgen receptors demonstrates the potential of this approach for targeting castration-resistant prostate cancer and overcoming drug resistance.
University students who were men who had sex with men (MSM) in Sichuan, China had a higher prevalence of insomnia and probable depression than their non-MSM counterparts: mediation via emotional dysregulations
Authors: Yu Yanqiu , Ng Joyce Hoi-Yuk , Wang Zixin , Tian Xiaobing , Lau Joseph T. F. 
Published: November 2024

Abstract
Background
Men who have sex with men studying in universities (MSM-US) frequently face multiple sexual minority stressors that potentially lead to maladaptive emotional regulations and mental problems. This study compared the prevalence of depression/insomnia between MSM-US and non-MSM male university students (NUS) and hypothesized that the potential differences would be mediated via emotional dysregulation styles (rumination and catastrophizing).

Methods
The study design was a cross-sectional study. NUS were recruited from a university-based survey using cluster sampling in three universities in China from June to October 2018, while MSM-US from the same university-based survey and the other community-based survey using convenience sampling. The effective samples size was 2,531 (292 MSM-US and 2,239 NUS). Structural equation modeling (SEM) was performed.

Results
MSM-US had significantly higher prevalence of both probable depression (55.1% versus 35.7%; OR = 4.85, 95% CI: 3.38–6.94) and moderate-to-severe clinical insomnia (17.3% versus 4.1%; OR = 2.21, 95% CI: 1.73–2.83) than NUS. MSM-US were also more likely than NUS to use emotional dysregulation styles (rumination/catastrophizing), which were correlated with probable depression/insomnia (r = 0.17 to 0.31). In the SEM, the differences in depression/insomnia between MSM-US and NUS were partially mediated by the latent variable of emotional dysregulation (rumination and catastrophizing), with effect sizes of 55.0% for probable depression and 33.6% for insomnia, respectively.

Conclusions
Depression and insomnia were prevalent among male university students in Sichuan, China. Furthermore, MSM-US were at increased risk than NUS for both mental problems; emotional dysregulation partially explained such differences. Future studies are warranted to confirm the findings, develop tailored interventions to address general and MSM-specific stressors and reduce rumination and catastrophizing, and examine whether similar patterns exist in other sexual minority groups.
Health matters: a statistical approach to understand childhood illnesses in the North-East States of India, 2019–2021
Authors: Ranjan Mukesh , Lalrotlinga  , Singh Ashutosh , Brajesh  , Vanlalhriatsaka  
Published: November 2024

AbstractThe present study explores the prevalence and socio-economic demographic factors affecting childhood illnesses. Diarrhoea, fever and ARI among under-five children in the North -East states of India using NFHS-5 data Kids file. Results showed that diarrhoea, ARI, and fever among the northeastern states were highest in Meghalaya.For diarrhoea Sikkim has the highest prevalence for children within 6 months while Meghalaya has the highest prevalence in the age groups 6- 12 months and 1- 2 years old children and Arunachal Pradesh has the highest rate in the age group 2- 5 years old children. Meghalaya stands out with the highest prevalence of fever and ARI in all age groups. Compared to Sikkim, the state of Meghalaya had more diarrhoea, ARI and fever, and it was statistically highly significant. However, Tripura and Assam had significantly higher odds of having fever and ARI than Sikkim. There is an association between diarrhoea, fever, and ARI and factors such as the age of the child and caregiver, the wealth status of the household, the quality of sanitation facilities, methods of stool disposal, and the caregiver's educational level.
Plasmodial slime moulds (myxomycetes) in Swedish and Nordic folk biology
Authors: Svanberg Ingvar , Ståhlberg Sabira 
Published: November 2024

Abstract
Background
Folk biology commonly contains knowledge of many more taxa than those of immediate economic importance. Species with little or no practical use are, however, often overlooked by ethnobiological research. An example are a few Myxomycetes taxa which played an important role in the folk biology and beliefs of pre-industrial Sweden and adjacent Nordic countries, Denmark, Norway and Finland. Such organisms are not of less interest for the understanding of human-biota relationships; local knowledge about the entire biota in a given environment should therefore be studied to comprehend the full range of folk biology.

Methodology
This qualitative study analyses and reviews historical data available in archives and published ethnographic collections as well as scattered and fragmentary notes in the literature using a historical ethnobiological approach.

Results
Peasants in the Nordic countries recognized three taxa of myxomycetes. Scrambled egg slime, Fuligo septica (L.) F.H.Wigg., in particular attracted interest and is known by many local folk names. This slime had no practical value or use, yet it was well known in folk biology and associated with a supernatural malevolent being which in the shape of a hare or cat stole milk or butter on behalf of a witch. The belief in evil origins of slime became the cause of violent actions such as whipping and burning of the organism. Two other taxa, Lycogala epidendron (L.) Fr. and Mucilago crustacea F.H.Wigg., have also been observed in folk biology, but data on how they were perceived and treated is sparse.

Conclusions
The sudden appearance of strange shapes and clear colours of myxomycetes in damp weather created both fear and curiosity; these odd organisms required explanations, interpretations and actions. Our example of the economically irrelevant myxomycetes in Sweden and nearby Nordic countries indicates that interpretations in pre-industrial societies of natural phenomena and various organisms, connections with beliefs and perceptions about the surrounding environment and the possible consequent actions should be studied alongside economic plants and animals in ethnobiological research, for a deeper understanding about folk biology and the multilayered and multidimensional relationships between humans and biota.
Nasljedna nepodnošljivost fruktoze – pregled literature i prikaz dvoje bolesnika
Authors: Paponja Kristina , Rahelić Valentina , Mesarić Nikola , Žigman Tamara , Škaričić Ana , Bilandžija-Kuš Iva , Pavić Eva , Senečić-Čala Irena , Peršić Mladen , Vuković Jurica , Barić Ivo , Ramadža Danijela Petković 
Published: November 2024

Nasljedna nepodnošljivost fruktoze ili fruktozemija je autosomno recesivno nasljedni poremećaj koji nastaje zbog nedostatne aktivnosti enzima fruktoza-1-fosfat aldolaze (aldolaze B). Bolest se klinički, u dotad naizgled zdravog dojenčeta, očituje nakon uvođenjanamirnica koje sadrže fruktozu, saharozu ili sorbitol. Najčešći simptomi bolesti su povraćanje, bljedilo, drhtavica, somnolencija, akatkad i konvulzije (većinom kao posljedica hipoglikemije, odnosno neuroglikopenije). Može se razviti i akutno zatajenje jetre, a akose dijete pravilno ne zbrine, takva kriza može završiti smrću. Pošto se fruktoza, saharoza i sorbitol isključe iz prehrane, simptomi bolesti se brzo i spontano povlače. Ako bolest ostane neprepoznata, dugoročno može uzrokovati ponavljajuće bolove u trbuhu,povraćanje, kroničnu bolest jetre, tubulopatiju, rahitis te zaostajanje u rastu i razvoju. Anamnestički podatci o pojavi simptoma nakon uvođenja voća i povrća u dohranu i/ili odbojnost prema slatkoj hrani ključni su za postavljanje sumnje na ovu bolest. Laboratorijski nalazi koji podupiru dijagnozu, a česti su u akutnom pogoršanju, su hipoglikemija, hipofosfatemija, hiperuricemija, metabolička acidoza i povišene aktivnosti aminotransferaza. Dijagnoza se potvrđuje nalazom bialelnih patogenih mutacija gena ALDOBili mjerenjem aktivnosti enzima u tkivu jetre ili crijeva, što se danas rjeđe primjenjuje. Pravodobno postavljanje dijagnoze ključno jeza dobar ishod. Ako se spriječi unos fruktoze u organizam, prognoza je izvrsna. Cilj ovog rada je predočiti klinička obilježja nasljednenepodnošljivosti fruktoze prikazom dvoje bolesnika, jednog s akutnim, a drugog sa subakutnim kliničkim tijekom, te tako upozoritina ovu rijetku, a lječivu nasljednu metaboličku bolest.
Artroskopije gležnja u djece i adolescenata
Authors: Dimnjaković Damjan , Tućin Krešimir , Smoljanović Tomislav , Bojanić Ivan 
Published: November 2024

U današnje je vrijeme artroskopija gležnja uobičajen zahvat, a njihov broj kontinuirano raste. Ciljevi ovog istraživanja bili su utvrditikoliki je udio artroskopija gležnja u djece i adolescenata u ukupnom broju artroskopskih zahvata na gležnju te utvrditi postoji li razlika u postotnom udjelu dijagnoza radi kojih se činila artroskopija gležnja između skupine djece i adolescenata i skupine odraslihosoba. Pretraživanjem operacijskih protokola Klinike za ortopediju KBC-a Zagreb i Medicinskog fakulteta Sveučilišta u Zagrebu pronađeno je da je u petogodišnjem razdoblju u 533-je bolesnika učinjena artroskopija gležnja, a 90-ero od njih je u trenutku zahvatabilo mlađe od 18 godina. Medicinsku dokumentaciju, koja je bila dostupna u elektroničkoj i papirnatoj bazi podataka Klinike za ortopediju, pregledao je liječnik koji nije sudjelovao u njihovom liječenju. U pedijatrijskoj populaciji bolesnika indikacija za artroskopski zahvat najčešće je postavljena ili radi sindroma anterolateralnog sraza ili radi koštano-hrskavičnog oštećenja kupole talusa,dok je u odraslih to bio sindrom prednjeg sraza. U svih je 90-ero ispitanika operacijski zahvat protekao bez komplikacija. U ranomposlijeoperacijskom praćenju zamijećene su samo dvije komplikacije. S obzirom na rezultate ovog istraživanja možemo zaključiti daje artroskopija gležnja pouzdana i učinkovita operacijska metoda liječenja različitih ozljeda i oštećenja gležnja u djece i adolescenata. Pritom valja istaknuti da su u toj populaciji bolesnika vodeće indikacije različite od vodećih indikacija u odraslih bolesnika.
Utjecaj željeza na rast i učestalost infekcija u dojenčadi
Authors: Kranjčec Izabela , Roganović Jelena 
Published: November 2024

Sideropenična anemija najčešća je defi citarna anemija u svijetu. Zahvaljujući brojnim primarnim i sekundarnim preventivnim mjerama, njena prevalencija u razvijenim zemljama je u značajnom padu, dok je u nerazvijenom svijetu i dalje veliki javnozdravstveniproblem. Pozitivan utjecaj željeza na djetetov rani psihomotorički razvoj desetljećima je poznat, dok utjecaj na linearni rast i učestalost infekcija ostaje kontroverzan. Rezultati našeg istraživanja upućuju na relativno visoku prevalenciju sideropenične anemije upopulaciji hrvatske dojenčadi (19,7% u dobi od 4 mjeseca, 32,4% u dobi od 6-9 mjeseci i 16,4% u dobi od 12 mjeseci). Željezo primijenjeno u profi laktičnim dozama, sukladno važećim smjernicama, ne utječe na linearni rast i učestalost infekcija (p>0,05), stogaje pouzdana i poželjna prevencija. S obzirom na dokazane negativne učinke sideropenične anemije, potrebno je podizati svijest roditelja o važnosti adekvatne prevencije i terapije anemije te poticati pedijatre na razini primarne zdravstvene zaštite na sustavnoprovođenje primarne i sekundarne prevencije
Diffraction model-driven neural network with semi-supervised training strategy for real-world 3D holographic photography
Authors: Fang Qiwei , Zheng Huadong , Xia Xinxing , Peng Junchang , Zhang Tengfei , Lin Xingyu , Yu Yingjie 
Published: November 2024

Compared to traditional 2D displays, 3D display technology provides richer information to the viewer. Learning-based computer-generated holography (CGH) has shown great potential in realizing real-time holographic 3D displays. However, most of the current learning-based CGH algorithms cannot quickly complete the training stage and produce high-quality holograms due to insufficient constraints in the training stage of the neural network. In this paper, we propose a diffractive model-driven neural network trained using a semi-supervised training (SST-holo) strategy and incorporate a state-of-the-art monocular depth estimation algorithm to achieve the fast generation of holograms of real-world 3D scenes. Compared to the supervised training strategy, our proposed semi-supervised training strategy does not require high-quality labeled datasets, but can significantly improve the imaging quality and generalization of the algorithm. Incorporating the Res-MSR block in SST-holo to adaptively learn image features of different scales enhances the learning capability of the network. In addition, we adopt a random splicing processing strategy to preprocess the dataset to ensure that the original features in the dataset are not corrupted. SST-holo can generate high-quality 3D phase-only holograms with 2 K resolution in 0.015 seconds. Both monochrome and color optical experiments show that the proposed algorithm has good 3D effect and generalization ability and can effectively improve the quality of reconstructed images.