bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daratumumab plus carfilzomib and dexamethasone in patients with relapsed or refractory multiple myeloma
Authors: Chari Ajai , Martinez-Lopez Joaquín , Mateos María-Victoria , Bladé Joan , Benboubker Lotfi , Oriol Albert , Arnulf Bertrand , Rodriguez-Otero Paula , Pineiro Luis , Jakubowiak Andrzej , de Boer Carla , Wang Jianping , Clemens Pamela L. , Ukropec Jon , Schecter Jordan , Lonial Sagar , Moreau Philippe 
Published: May 2019

Abstract
Patients with relapsed or refractory multiple myeloma (RRMM) have limited treatment options and poor survival outcomes. The increasing adoption of lenalidomide-based therapy for frontline treatment of multiple myeloma has resulted in a need for effective regimens for lenalidomide-refractory patients. This phase 1b study evaluated daratumumab plus carfilzomib and dexamethasone (D-Kd) in patients with RRMM after 1 to 3 prior lines of therapy, including bortezomib and an immunomodulatory drug; lenalidomide-refractory patients were eligible. Carfilzomib- and daratumumab-naïve patients (n = 85) received carfilzomib weekly on days 1, 8, and 15 of each 28-day cycle (20 mg/m2 initial dose, escalated to 70 mg/m2 thereafter) and dexamethasone (40 mg/wk). Of these, 10 patients received the first daratumumab dose as a single infusion (16 mg/kg, day 1 cycle 1), and 75 patients received a split first dose (8 mg/kg, days 1-2 cycle 1). Subsequent dosing was per the approved schedule for daratumumab. Patients received a median of 2 (range, 1-4) prior lines of therapy; 60% were lenalidomide refractory. The most common grade 3/4 treatment-emergent adverse events were thrombocytopenia (31%), lymphopenia (24%), anemia (21%), and neutropenia (21%). Infusion-related reactions were observed in 60% and 43% of single and split first-dose patients, respectively. Overall response rate was 84% (79% in lenalidomide-refractory patients). Median progression-free survival (PFS) was not reached; 12-month PFS rates were 74% for all treated patients and 65% for lenalidomide-refractory patients. D-Kd was well tolerated with low neutropenia rates, and it demonstrated deep responses and encouraging PFS, including in patients refractory to lenalidomide. The trial was registered at www.clinicaltrials.gov as #NCT01998971.
Predictors of delirium after cardiac surgery in patients with sleep disordered breathing
Authors: Tafelmeier Maria , Knapp Marvin , Lebek Simon , Floerchinger Bernhard , Camboni Daniele , Creutzenberg Marcus , Wittmann Sigrid , Zeman Florian , Schmid Christof , Maier Lars Siegfried , Wagner Stefan , Arzt Michael 
Published: May 2019

IntroductionDelirium ranks among the most common complications after cardiac surgery. Although various risk factors have been identified, the association between sleep disordered breathing (SDB) and delirium has barely been examined so far. Here, our objectives were to determine the incidence of post-operative delirium and to identify the risk factors for delirium in patients with and without SDB.MethodsThis subanalysis of the ongoing prospective observational study CONSIDER-AF (ClinicalTrials.govidentifierNCT02877745) examined risk factors for delirium in 141 patients undergoing cardiac surgery. The presence and type of SDB were assessed with a portable SDB monitor the night before surgery. Delirium was prospectively assessed with the validated Confusion Assessment Method for the Intensive Care Unit on the day of extubation and for a maximum of 3 days.ResultsDelirium was diagnosed in 23% of patients: in 16% of patients without SDB, in 13% with obstructive sleep apnoea and in 49% with central sleep apnoea. Multivariable logistic regression analysis showed that delirium was independently associated with age ≥70 years (OR 5.63, 95% CI 1.79–17.68; p=0.003), central sleep apnoea (OR 4.99, 95% CI 1.41–17.69; p=0.013) and heart failure (OR 3.3, 95% CI 1.06–10.35; p=0.039). Length of hospital stay and time spent in the intensive care unit/intermediate care setting were significantly longer for patients with delirium.ConclusionsAmong the established risk factors for delirium, central sleep apnoea was independently associated with delirium. Our findings contribute to identifying patients at high risk of developing post-operative delirium who may benefit from intensified delirium prevention strategies.
Ensuring research integrity: setting standards for robust and ethical conduct and reporting of research
Authors: Bhui Kamaldeep S. , Lee William , Kaufman Kenneth R. , Lawrie Stephen M. 
Published: May 2019

SummaryWe present an account of why we decided to retract a paper. We discovered a lack of adherence to conventional trials registration, execution, interpretation and reporting, and consequently, with the authors, needed to correct the scientific record. We set out our responses in general to strengthen research integrity.Declaration of interestK.S.B. is Editor-in-Chief of the British Journal of Psychiatry. W.L., K.R.K. and S.M.L. are members of the senior editorial committee and the research integrity committee for the journal. In the past three years, S.M.L. has received research support from Janssen and Lundbeck, and personal support from Janssen, Otsuka and Sunovion.
Financial Toxicity After Cancer in a Setting With Universal Health Coverage: A Call for Urgent Action
Authors: Bhoo-Pathy Nirmala , Ng Chiu-Wan , Lim Gerard Chin-Chye , Tamin Nor Saleha Ibrahim , Sullivan Richard , Bhoo-Pathy Nanthini Thevi , Abdullah Matin Mellor , Kimman Merel , Subramaniam Shridevi , Saad Marniza , Taib Nur Aishah , Chang Kian-Meng , Goh Pik-Pin , Yip Cheng-Har 
Published: May 2019

BACKGROUND: Financial toxicity negatively affects the well-being of cancer survivors. We examined the incidence, cost drivers, and factors associated with financial toxicity after cancer in an upper-middle-income country with universal health coverage. METHODS: Through the Association of Southeast Asian Nations Costs in Oncology study, 1,294 newly diagnosed patients with cancer (Ministry of Health [MOH] hospitals [n = 577], a public university hospital [n = 642], private hospitals [n = 75]) were observed in Malaysia. Cost diaries and questionnaires were used to measure incidence of financial toxicity, encompassing financial catastrophe (FC; out-of-pocket costs ≥ 30% of annual household income), medical impoverishment (decrease in household income from above the national poverty line to below that line after subtraction of cancer-related costs), and economic hardship (inability to make necessary household payments). Predictors of financial toxicity were determined using multivariable analyses. RESULTS: One fifth of patients had private health insurance. Incidence of FC at 1 year was 51% (MOH hospitals, 33%; public university hospital, 65%; private hospitals, 72%). Thirty-three percent of households were impoverished at 1 year. Economic hardship was reported by 47% of families. Risk of FC attributed to conventional medical care alone was 18% (MOH hospitals, 5%; public university hospital, 24%; private hospitals, 67%). Inclusion of expenditures on nonmedical goods and services inflated the risk of financial toxicity in public hospitals. Low-income status, type of hospital, and lack of health insurance were strong predictors of FC. CONCLUSION: Patients with cancer may not be fully protected against financial hardships, even in settings with universal health coverage. Nonmedical costs also contribute as important drivers of financial toxicity in these settings.
Lithium-Richest Phase of Lithium Tetrelides Li17Tt4 (Tt = Si, Ge, Sn, and Pb) as an Electride
Authors: Tsuji Yuta , Hashimoto Wataru , Yoshizawa Kazunari 
Published: May 2019

Abstract
The lithium-richest phase in the binary Li-Tt system (Tt = Si, Ge, Sn, and Pb) has a stoichiometry of Li17Tt4. In the beginning of this paper, the structural complexity of Li17Tt4 is gradually stripped away using the concept of the M26 cluster found in γ-brass structures and a Tt-centered polyhedral representation. By means of the first-principles electronic structure calculations, which are followed by the analyses of the electron localization function (ELF), Bader charges, and spin density, we observe non-nuclear maxima of the ELF, electron density, and spin density. Since the electron densities off the atoms are confined in crystalline voids, separated from each other, and behaving as an anion, Li17Tt4 can be identified as a potential zero-dimensional electride. This finding agrees with a simple Zintl picture, which suggests a valence electron count of [(Li+)17(Tt4−)4·e−]. Detailed analyses on the band structures, the projected density of states, and crystal orbitals at the Γ point in the reciprocal space hint at the potential of forming a bond between the non-nuclear electron density and the neighboring atoms. Signatures of bonding and anti-bonding orbital interactions can be witnessed.
Establishing how patient size and degree of miscentring affect CTDIvol, using patient data from a dose tracking system
Authors: Cournane Sean , Brunell Eimear , Rowan Michael 
Published: May 2019

Objectives:
The work aimed to investigate and model the relationship between CT dose index (CTDIvol), patient size and miscentring metrics using data extracted from a dose tracking software tool. Further, using the established model we aimed to extract and estimate further AEC metrics and, finally, demonstrate how the CTDIvol may vary across a range of imaging exams and with variations in patient size, positional metrics and with scan parameters.

Methods:
CT scan parameters, patient dose metrics, patient positioning information and patient and water equivalent diameter information was extracted from abdomen, thorax–abdomen–pelvis and thorax imaging exams acquired on a 128-slice Siemens Somatom Definition AS + CT system using dose tracking software over a 1 year period. A miscentring factor, accounting for the magnification of the patient due to miscentring was derived. Significant predictors ( p-value &lt; 0.001) of the CTDIvol were considered as inputs into the model following regression analysis.

Results:
The model was capable of describing the CTDIvol and its variation with patient miscentring and patient size. AEC parameters, such as the reference CTDIvol, reference diameter and the AEC strength were estimated. Further, the model allowed for comparisons of how changes in scan settings, such as kVp, pitch and slice thickness affected CTDIvol.

Conclusions:
We demonstrate the use of clinical data, extracted from dose tracking software, to investigate and monitor AEC behaviour and CT output.

Advances in knowledge:
The presented model allows for the remote investigation of AEC behaviour using patient data.
Accuracy of radiologic– laparoscopic peritoneal carcinomatosis categorization in the prediction of surgical outcome
Authors: Abdalla Ahmed Shimaa , Abou-Taleb Hisham , Ali Noha , M. Badary Dalia 
Published: May 2019

Objective:
To evaluate the agreement between multiple detector CT (MDCT) and laparoscopy in the preoperative categorization of peritoneal carcinomatosis, and to determine the impact of this categorization on the prediction of cytoreduction status.

Methods:
This prospective study included 80 consecutive females with primary ovarian cancer eligible for cytoreductive surgery (CRS). MDCT and diagnostic laparoscopy were performed prior to surgery for assessment of peritoneal carcinomatosis extent. Based on PCI (peritoneal cancer index) score, carcinomatosis was categorized into three groups. Categorization agreement between CT and laparoscopy was assessed and compared with the intraoperative-histopathologically proven PCI. Impact of PCI categorization on cytoreduction status was also evaluated.

Results:
The overall agreement between CT and laparoscopy in preoperative peritoneal carcinomatosis categorization was good (K =0.71-0.79) in low category group and excellent in both moderate and large group (interclass correlation coeeficient = 0.89–0.91). (p&lt;0.01)
Optimal cytoreduction was achieved in 62/80 (77.5%) patients, PCI &lt; 20 was detected in 48/62 (77.4%), pre-operative PCI &lt; 20 correctly predicted optimal cytoreductive surgery (OCS) in 40/48 (83.3%) cases.
Suboptimal cytoreduction was performed in 18/80 (22.5%) patients. PCI &gt; 20 was detected in (10/18) 55.6%, preoperative CT and laparoscopy PCI &gt; 20 correctly predicted SCS in 8/10 (80%) cases.
The area under receiver operating characteristic curve showed that PCI cut-off &lt;20 was the best predictor of OCS with an accuracy 85%, sensitivity 97%, specificity 40%, negative predictive value 76%, and positive predictive value 93%.

Conclusion:
Both laparoscopy and CT are equally effective in pre-operative peritoneal carcinomatosis categorization. PCI &lt; 20 is accurate in the prediction of optimal cytoreduction. More than half of patients with suboptimal cytoreduction had PCI &gt; 20 and interval debulking surgery can be recommended.

Advances in knowledge:
Both laparoscopy and CT are equally effective in pre-operative peritoneal carcinomatosis categorization. PCI &lt; 20 is accurate in the prediction of optimal cytoreduction. More than half of patients with suboptimal cytoreduction had PCI &gt; 20 and interval debulking surgery can be recommended.
Ethno-cultural development of children of preschool age in the process of connection to decorative-applied art
Authors: Alexandrovich Chernobrovkin Vladimir , Ferola Bianca Carvalho 
Published: May 2019

The article updates and substantiates the role of ethno-cultural education of Russian children of senior preschool age in the process of acquaintance with arts and crafts. The theoretical and methodological foundations of the ethno-cultural education of children of the senior preschool age are studied in the process of acquaintance with arts and crafts, the ethno-cultural education of preschool children as a social and psychological and pedagogical phenomenon is described, the state of program and methodical support for the realization of ethno-cultural education of preschool children in modern conditions of development of preschool education is analysed, the role of arts and crafts in ethno-cultural education of children of senior preschool age in Russia is defined.The article suggests a set of measures, including a special program "We are wizards", aimed at the ethno-cultural education of senior preschoolers, which can be recommended to the mass practice of teachers of pre-school general educational institutions and teachers of additional education for children.
KEYWORDS: Ethno-culture. Ethno-cultural education. Folk culture. Arts and crafts. Ethno-cultural skill.
Arqueologia e linguística: Construindo as trajetórias histórico-culturais dos povos Tupí
Authors: Silva Fabíola Andréa , Noelli Francisco Silva 
Published: May 2019

Entender as causas e os significados da variabilidade e da padronização artefatual encontradas no registro arqueológico é um dos principais objetivos da pesquisa arqueológica. Neste texto pretendemos mostrar como o diálogo interdisciplinar é fundamental para que alcancemos tal objetivo e, para isso, tomaremos como exemplo o estudo das trajetórias histórico-culturais das populações Tupi, dando ênfase Ã relação profícua entre arqueologia e linguística.
Refinements of the Hermite–Hadamard inequality for co-ordinated convex mappings
Authors: Budak Huseyin , Usta Fuat , Sarikaya Mehmet Zeki 
Published: May 2019

Abstract
This paper is motivated by the recent progress on the Hermite–Hadamard inequality for convex functions defined on the bounded closed interval, obtained by Z. Pavić [Z. Pavić,
Improvements of the Hermite–Hadamard inequality,
J. Inequal. Appl. 2015 2015, Article ID 222].
As a generalization, we obtained a new refinement of the Hermite–Hadamard inequality for co-ordinated convex functions defined on the rectangle.
Decay rates for a coupled quasilinear system of nonlinear viscoelastic equations
Authors: Mustafa Muhammad I. , Kafini Mohammad 
Published: May 2019

Abstract
In this paper, we consider a nonlinear quasilinear system of two coupled viscoelastic equations and investigate the asymptotic behavior of this system.
We establish an explicit and general formula for the energy decay rates.
Our result allows a wider class of relaxation functions, which improves earlier results existing in the literature.
A note on the regularity of weak solutions to the coupled 2D Allen–Cahn–Navier–Stokes system
Authors: Tachim Medjo T. 
Published: May 2019

Abstract
In this article, we study a coupled Allen–Cahn–Navier–Stokes model in a two-dimensional domain.
The model consists of the Navier–Stokes equations for the velocity, coupled with an Allen–Cahn model for the order (phase) parameter.
We present an equivalent weak formulation for the model, and we prove a new regularity result for the weak solutions.
The Organised Self and Lifestyle Minimalism: Multimodal Deixis and Point of View in Decluttering Vlogs on YouTube
Authors: Zappavigna Michele 
Published: May 2019

Abstract
This paper explores how people present their relationship to their domestic objects in decluttering vlogs on YouTube, where they show the process of getting rid of undesired items. These videos are associated with discourses of ‘minimalism’ that are currently prevalent on social media platforms. The paper adopts a multimodal social semiotic approach, focusing on how language, gesture, and the visual frame coordinate intermodally to make meanings about objects. The multimodal construction of deixis in coordination with a type of ‘point-of-view shot’, filmed from the visual perspective of the vlogger, is examined. The broader aim is to investigate what these videos reveal about how digital semiotic capitalism is inflecting the lived experience of social media users. What is at stake is how people articulate intersubjective meanings about their experiences and relationships through the way they communicate about their objects.
Piezo-electrets from polypropylene composites doped with mineral fillers
Authors: Kaczmarek Halina , Chylińska Marta , Klimiec Ewa , Królikowski Bogusław , Sionkowski Grzegorz , Machnik Monika 
Published: May 2019

Abstract
PP-based composites with two mineral fillers (perlite or glass beads) were manufactured by extrusion, and then subjected to orientation in a ratio of 3:1. Electrets were obtained in the polarization process under the influence of a constant electric field. Sample morphology was tested by SEM whereas the crystallinity was determined by XRD. Mechanical strength and thermal stability of composites was studied by tensile tests and thermogravimetric analysis, respectively. The piezoelectric characteristics were appointed by measurement of the electrical charge and current voltage in the polarized samples. The dependence of thermally stimulated depolarized current (TSDC) on temperature was also investigated. The piezoelectric coefficient (d33), the electret stability over time as well as activation energy of depolarization process have been determined. It was found that low filler content (i.e. 2.5 and 5 wt.% of glass beads and perlite, respectively) significantly improve piezoelectric properties of isotactic polypropylene (i-PP).
Finite semiotics: Cognitive sets, semiotic vectors, and semiosic oscillation
Authors: Shackell Cameron 
Published: May 2019

Abstract
The grounding of semiotics in the finiteness of cognition is extended into constructs and methods for analysis by incorporating the assumption that cognition can be similar within and between agents. After examining and formalizing cognitive similarity as an ontological commitment, the recurrence of cognitive states is examined in terms of a “cognitive set.” In the individual, the cognitive set is seen as evolving under the bidirectional, cyclical determination of thought by the historical environment. At the population level, the distributed “global” cognitive set is argued to be constrained to a manifold in which the cognition of individuals is determined only when their cognitive sets meet certain conditions in the world: a result seen as consistent with Lotman’s semiosphere.
With these foundations in place, dimensional modelling of the semiosic field is inaugurated. Firstly, measures of cognitive similarity are formalized as cognitive “distance” and on this basis the concept of a semiotic vector is defined. Secondly, semiotic vectors are seen to shape a general pattern of oscillation in semiosis, and thus to imply zero points in semiosic potential. Thirdly, semiosic oscillation in individual agents is shown to be consistent with a novel diachronic or longitudinal interpretation of Greimas’ semiotic square expanded into a “semiotic pipe” in which cognition traverses an n-dimensional space structured by axes of oscillation. Finally, the expanded theory of finite semiotics is advanced as a useful basis for two new complementary disciplines: (1) a computational, mathematical science of “natural semiotic processing” (NSP) to trace and model semiotic vectors and oscillation; and (2) an ethical, rhetorical art of “technological influencing” (TI) to guide its inputs and applications.
Facile synthesis of model 2,4-diaryl-1,3,4-thiadiazino[5,6-h]fluoroquinolones
Authors: Abadleh Mohammed M. , Arafat Tawfiq , Abu-Qatouseh Luay , El-Abadelah Mustafa M. , Awwadi Firas F. , Voelter Wolfgang 
Published: May 2019

Abstract
A Selected set of 2,4-diaryl-7-oxo-1,2,4-thiadiazino[5,6-h]quinoline-8-carboxylic acids 6a–e has been prepared via reaction of the parent 7-chloro-8-nitro-10-cyclopropyl-6-fluoroquinolone 4 with the appropriate N′-(aryl)benzothiohydrazide 5a–e in presence of triethylamine. Structures of the new heterocyclics 6a–e are supported by spectral data and confirmed by single-crystal X-ray crystallography for 6a.
Using Thermal Gradient Measurements to Compare Bath Temperature and Agitation Effects on the Quenching Performance of Palm Oil, Canola Oil and a Conventional Petroleum Oil
Authors: Matijevic Bozidar , Canale Bruno F. , Liscic Bozidar , Totten George E. 
Published: May 2019

Abstract
A proprietary Liscic/Petrofer cylindrical Inconel 600 probe of 50-mm diameter and 200-mm length which was instrumented with three thermocouples on the same radius of the cross-section at the middle of the length was used to determine the differences in quenching performance of two vegetable oils, palm oil and canola oil, and they were compared to a locally produced conventional petroleum oil quenchant. The cooling curves and heat transfer performance of these oils were determined at different bath temperatures and agitation rates. The work was performed at the Quenching Research Centre located at the Faculty for Mechanical Engineering, University of Zagreb, Croatia. The results of this comparative study are reported herein.
Ilgalaikio nedarbo tendencijų ir regioninių skirtumų įvertinimas Lietuvoje
Authors: Pocius Arūnas , Miežienė Rasa 
Published: May 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Straipsnis parengtas remiantis Nacionalinės mokslo programos „Gerovės visuomenė“ 2017–2018 m. projekto „Regioniniai gerovės skirtumai Lietuvoje“ rezultatais (projekto Nr. GER-005/2017). Projektą finansuoja Lietuvos mokslo taryba. Publikacijoje vertinamos ilgalaikio nedarbo tendencijos šalyje ir bedarbių skaičiaus raida pagal nedarbo trukmę, analizuojami ilgalaikio nedarbo lygio skirtumai Lietuvoje ir lyginami su ES šalimis. Bene esminiai šios publikacijos prioritetai – regioninių ilgalaikio nedarbo skirtumų įvertinimas bei kaimo ir miesto gyventojų ilgalaikio nedarbo skirtumų kaitos analizė. Atsižvelgiant į informacijos disponavimo ir jos palyginamumo galimybes, tyrimo eigoje pasinaudota Lietuvos statistikos departamento (LSD), Europos Sąjungos statistikos tarnybos (Eurostato) bei Užimtumo tarnybos1 prie Lietuvos Respublikos socialinės apsaugos ir darbo ministerijos (Užimtumo tarnybos) duomenimis.