bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecological stoichiometry and adult fat reserves suggest bet-hedging inDrosophila melanogasterdevelopment
Authors: Krama Tatjana , Krams Ronalds , Jõers Priit , Munkevics Māris , Trakimas Giedrius , Luoto Severi , Eichler Sarah , Butler David M. , Merivee Enno , Must Anne , Rantala Markus J. , Contreras-Garduño Jorge , Krams Indrikis 
Published: September 2019

AbstractThe elemental composition of organisms relates to a suite of functional traits that change during development in response to environmental conditions. It may be a part of a phenomenon known as ‘developmental programming’, which hypothetically creates phenotypes that are better adapted to their environments. However, associations between developmental speed and elemental body composition are not well understood. We compared body mass, elemental body composition, food uptake and fat metabolism ofDrosophila melanogasterOregon-R male fruit flies across the time gradient of their larval development. The results showed that flies with intermediate and rapid developmental speeds were heavier than slowly developing flies. Slowly developing flies had higher body carbon concentration than rapidly developing and intermediate flies. Rapidly developing flies had the highest body nitrogen concentration, while slowly developing flies had higher body nitrogen levels than flies with intermediate speed of development. The carbon-to-nitrogen ratio was therefore lower in rapidly developing flies than in slow and intermediate flies. Feeding rates were lowest in the slowly developing flies. The amount of storage fats was highest in the intermediate group. This means that the growth of rapidly developing flies is not suppressed by stress and they actively convert the food they consume into growth with less emphasis on storage build-up, suggesting bet-hedging in the larval development. In contrast, flies in the intermediate developmental group had the greatest fat reserves which optimize fitness under many climatic conditions. Low food intake may slow down development and the accumulation of body fat reserves in slowly developing flies. However, at the cost of slower growth, their phenotype conceivably facilitates survival under higher stochasticity of their ephemeral environments spoiled by metabolic waste due to high density of conspecifics. Overall, this study suggests that bet-hedging may be a common developmental strategy in fruit flies to cope with environmental uncertainty.
Early loss of Scribble affects cortical development and interhemispheric connectivity resulting in psychomotor dysregulation
Authors: Ezan Jerome , Moreau Maité M. , Mamo Tamrat M. , Shimbo Miki , Decroo Maureen , Richter Melanie , Peyroutou Ronan , Rachel Rivka , Tissir Fadel , de Anda Froylan Calderon , Sans Nathalie , Montcouquiol Mireille 
Published: September 2019

AbstractNeurodevelopmental disorders arise from combined defects in processes including cell proliferation, differentiation, migration and commissure formation. The evolutionarily conserved tumor-suppressor protein Scribble (Scrib) serves as a nexus to transduce signals for the establishment of apicobasal and planar cell polarity during these processes. Human SCRIB gene mutations are associated with neural tube defects and this gene is located in the minimal critical region deleted in the rare Verheij syndrome. In this study, we generated brain-specific conditional cKO mouse mutants and assessed the impact of the Scrib deletion on brain morphogenesis and behavior. We showed that embryonic deletion of Scrib in the telencephalon leads to cortical thickness reduction (microcephaly) and alteration of interhemispheric connectivity (corpus callosum and hippocampal commissure agenesis). We correlated these phenotypes with the identification of novel roles for Scrib, both cell- and non-cell-autonomous, on neuronal migration and axonal guidance respectively. Finally, we show that Scrib cKO mice have psychomotor deficits such as locomotor activity impairment and memory alterations. Altogether, we show that Scrib is essential for early brain development and that the outcomes of its brain-specific disruption support a direct or indirect participation of Scrib to neurodevelopmental pathologies.
Pharmacogenetic variants associated with off-target adverse drug reactions are mostly predicted to be benign
Authors: McConnell Hannah , Field Matthew A , Andrews T. Daniel 
Published: September 2019

AbstractTools that predict the functional importance of genetic variation almost always rely on sequence conservation across deep evolutionary divergences as a primary discriminator. However, sequence conservation information is misleading when predicting the functional importance of pharmacogenetic variants related to off-target adverse drug reactions. Sequence conservation is largely maintained by evolutionary purifying selection, which has not been relevant for most drugs until very recently, especially for off-target effects. Here, we use a simple classification criteria to identify variants with off-target pharmacogenetic effects from the PharmGKB database. We show that off-target pharmacogenetic variation is predicted mostly to be benign by all state-of-the-art prediction tools we tested. Hence, off-target pharmacogenetic variants are overwhelmingly invisible to all predictive methodologies currently employed. Very different analytical approaches will be needed to address this important problem.Author SummaryWhen a personal genome sequence is obtained for a given person, the sequence is compared to the human reference sequence to identify where it differs from the genome of that person. One application of this information is that it may identify how a specific person may react to particular drugs. However, when computationally predicting the functional importance of a genetic variant, the tools used rely heavily on sequence conservation information to make their prediction. From an evolutionary point of view, the use of drugs to treat diseases is a very recent activity – and one that has not had time to cause certain variants to either be selected for or removed from the population. This produces a blind-spot for tools that predict variant functional effects, especially for drugs with off-target interactions that may produce unanticipated effects.
Activity manipulation of an excitatory interneuron, during an embryonic critical period, alters network tuning of theDrosophilalarval locomotor circuit
Authors: Giachello Carlo N. G. , Fan Yuen Ngan , Landgraf Matthias , Baines Richard A. 
Published: September 2019

AbstractAs nervous systems develop, activity perturbations during critical periods can lead to permanently altered network function. However, how activity perturbation influences individual synapses, the network response and the underlying signalling mechanisms are not well understood. Here, we exploit a recently identified critical period in the development of theDrosophilalarval locomotor circuit to show that activity perturbation differentially affects individual and identified synaptic pairings. Remarkably, we further show that activity-manipulation of a selective excitatory interneuron is sufficient to fully recapitulate the effects induced by network-wide activity disturbance; indicative that some neurons make a greater contribution to network tuning. We identify nitric oxide (NO)-signalling as a potential mediator of activity-dependent network tuning during the critical period. Significantly, the effect of NO-signalling to network tuning is dictated by the prior activity state of the network. Thus, this study provides mechanistic insight that is currently lacking into how activity during a critical period tunes a developing network.
Monitoring progress in “quality education” in the European Union – strategic framework and goals
Authors: Pleśniarska Aleksandra 
Published: September 2019

Purpose
The purpose of this paper is to identify and discuss the most important initiatives and the strategic framework of the European Union (EU) supporting the 2030 Agenda for Sustainable Development. This paper also presents an overview of the progress towards the 4th Sustainable Development Goal (quality education) mainly in tertiary and adult education in the EU context.

Design/methodology/approach
The adopted research method includes a literature survey, a study of law regulations and strategic documents of the EU and their critical analysis. The main axis of empirical investigation is a comparative analysis. Thematic scope of the analysis embraces indicators such as tertiary educational attainment, employment rate of recent graduates and adult participation in learning.

Findings
The results of the comparative analysis confirm the diversity between Member States in achieving the goals of sustainable development. Overall positive trends in the development of quality education can be observed in the EU. However, the gender gaps in tertiary educational attainment and in the employment rate of recent graduates have been widening. Moreover, the EU is not on track to meet its 2020 benchmarks for adult participation in learning.

Originality/value
The paper systematizes knowledge of initiatives of the EU for sustainable development and supplements it with a comparative analysis in the field of statistical data, which allows for a better understanding of the state and the prospects of implementing the idea of quality education at the EU level.
Impact of investor sentiment on decision-making in Indian stock market: an empirical analysis
Authors: P.H. Haritha , Uchil Rashmi 
Published: September 2019

Purpose
The purpose of this paper is to analyze the relationship between the factors influencing investors sentiment and investment decision-making (DM) of the individual investors. This paper proposes a unique conceptual framework that incorporates the herding, market and awareness factors that are leading to investor sentiment (IS) and decision-making process of the individual investors.

Design/methodology/approach
This study has conducted a questionnaire-based survey to collect data from 875 individual investors through the convenience sampling method. Structural equation modeling was used to evaluate the relationship between factors, namely, market effect, herd behavior, media, social interaction and advocate recommendation that influences IS and DM.

Findings
The present study found that market effect and herding are the most significantly influencing factors of investors sentiment. Among the sources of awareness, the internet has the lowest influence when compared to media, social interaction and advocate recommendation.

Practical implications
This study will help individual investors to avoid the problems faced while making an investment decision. The study could help investors to select a suitable investment aid and avoid repeating expensive errors, which arise due to investors’ sentiment. It is recommended to increase the awareness regarding investors’ sentiment among individuals, so as to increase their understanding about the financial settings and to make them confident while investing. The present study also sheds light upon the behavior of Indian individual investors so that policymakers can take appropriate measures to provide the proper guidance. Policymakers can conduct awareness campaigns to increase investors’ knowledge on the market condition and to enhance proper investment DM among them.

Originality/value
To best of the authors’ knowledge, previous studies have focused on limited factors at a time. The present study has investigated how factors influencing investors sentiment, namely, market factors (MF), herding as well as awareness would influence investment DM among individual investors in India. The influence of these factors has never been studied simultaneously in the context of Indian individual investors’ DM.
Instagram fashionistas, luxury visual image strategies and vanity
Authors: Jin S. Venus , Ryu Ehri 
Published: September 2019

Purpose
Luxury fashion brands harness the power of Instagram and fashionistas for strategic brand management. This study aims to test interaction effects among luxury brand posts’ Instagram source type (brand versus fashionista), visual image type (product-centric versus consumer-centric) and consumers’ characteristics (vanity, opinion leadership and fashion consciousness) on brand recognition and trust.

Design/methodology/approach
A quantitative 2 (source type: brand versus fashionista) × 2 (branded visual image type: product-centric luxury versus consumer-centric luxury) between-subjects online experiment (N males = 195 and N females = 182) was conducted by recruiting participants from MTurk.

Findings
Logistic regression analyses indicated two-way interaction effects between sources and visual images on brand recognition. Brand recognition was higher for product-centric images when the source was the fashionista, whereas brand recognition was equivalent regardless of the image type when the source was the brand. Logistic regression and multiple regression analyses revealed the moderating effects of sources and visual images on the association between consumer traits and branding outcomes.

Practical implications
Meticulously choosing effective methods of showcasing branded content and persuasive luxury visual image strategies via Instagram is more important for fashionistas than for established brands in increasing brand recognition. Instagram fashionistas are more effective in increasing females’ brand trust through delivering product-centric visual images when targeting women with high vanity, opinion leadership and fashion consciousness. Brands as the Instagram profile source are more persuasive in increasing males’ brand trust through delivering product-centric visual images when targeting men with high vanity.

Originality/value
This experiment provides theoretical discussions and empirical findings about social media influencer marketing and managerial implications for Instagram-based luxury branding. This research revolves around the overarching theme of the interactive effects of multifaceted branded contents and market segments in social media influencer marketing environments.
Property valuation: the market approach optimised by a weighted appraisal model
Authors: Tajani Francesco , Morano Pierluigi , Salvo Francesca , De Ruggiero Manuela 
Published: September 2019

Purpose
The purpose of this paper is to develop an innovative model that can be included within the market approach methods for property valuations. The algorithm takes into account the frequent high level of dissimilarity of the comparables selected for the assessment, thus providing for the use of appropriate similarity and reliability coefficients capable of weighing the data of the comparison sample with respect to the different degrees of similarity and reliability.

Design/methodology/approach
The proposed model borrows the operative logics of the goal programming techniques, in order to identify the solution, the market value of the subject property and the implicit prices of the different influencing factors, since they are more reliable from the mathematical and empirical points of view.

Findings
The model has been applied to two case studies, relating to samples of residential properties located in the city of Naples (Southern Italy). The results obtained have outlined the high valuation performance of the developed appraisal model, capable of overcoming the applicability limits of classical market approach methods as well as providing solutions that are highly consistent with the expected empirical phenomena.

Practical implications
The research takes into account the growing need of both professionals and end users (banks, courts, public and private Entities, etc.) for valuation models that are easily repeatable and sufficiently objective. They are required in order to allow for the rapid verification of the elaborations carried out as well as to check the valuer’s appreciation of the contribution of the influencing factors in the market price formation. The outputs of the two applications developed have highlighted the ability of the proposed model to satisfy these market requests.

Originality/value
The proposed model can be easily implemented through a simple calculation program, with the mathematical structure elaborated allowing to overcome some application limits of the classical market approach methods. Furthermore, the introduction in the algorithm of appropriate similarity and reliability coefficients, capable of suitably weighting the data of the comparison sample, allows to widen the spatial horizon for the identification of the comparables as well as select properties characterized by a high level of dissimilarity. This makes it possible to apply the model in territorial contexts characterized by markets that are not excessively dynamic.
Kindred Spirits: Learning to Love Nature the Posthuman Way
Authors: Engelmann Sebastian 
Published: September 2019

Abstract
In times of ecological crisis Education for Sustainable Development (ESD) becomes more and more important. However, ESD mostly understands nature as a resource that must be catered to for securing the survival of mankind. This article criticises the anthropocentric foundation of ESD. Therefore, the article first introduces the concept of ‘making kin’ by Donna Haraway enriched with a critical discussion of subjectivity and agency by Judith Butler. Making kin describes a process that understands entities besides human beings as equal partners in action and symmetrical parts in networks of agents. Instead of understanding human subjects as the only nodes of power, Haraway grasps the social world as a string figure in which different knots are equally important for acting, living and dying together. Second, the article offers a re-reading of Bernhard Heinrich Blasche's text Naturbildung, focusing on the process of making kin implicitly sketched out in this text. The German text from the 18th century is evaluated with regard to its understanding of nature and interconnectedness of life-forms. I argue that Blasche's understanding of the human situatedness in an environment can be read as a predecessor to posthumanist understandings of nature, culture and agency. Finally, the paper connects the different threads and argues for a posthumanist understanding of love. Instead of love for the world, affectionate love in the world is not limited to human entities. A general understanding of love as the foundational principle of awareness, interconnectedness and situatedness is introduced that can enrich the discussion of pedagogical love.
Still blurry? Economic salience, position and voting for radical right parties in Western Europe
Authors: ROVNY JAN , POLK JONATHAN 
Published: September 2019

AbstractDo radical right parties present blurry economic stances, or have they clarified their positions while moving towards the economic left? This article questions the strategic behaviour of radical right parties in Western Europe. It shows that although radical right parties have increased their discussion of economic issues, and expert placements of this party family on the economic dimension have become more centrist over time, the uncertainty surrounding these placements continues to be higher for the radical right than any other party family in Europe. The article then moves on to examine to what extent voter‐party congruence on redistribution, immigration and other issues of social lifestyle predict an individual's propensity to vote for the radical right compared to other parties. Although redistribution is the component of economic policy where the radical right seems to be centrist, the findings indicate that it remains party‐voter congruence on immigration that drives support for radical right parties, while the congruence level for redistribution has an insignificant effect. The article concludes that while radical right parties seem to have included some clearly left‐leaning economic proposals, which shifted the general expert views of these parties to the economic centre, their overall economic profiles remain as blurry as ever.
Postoperative discomfort after implant placement according to the All‐on‐4 concept with or without Zygoma implants: A prospective clinical study
Authors: Korsch Michael , Baum Alexandra , Bartols Andreas 
Published: September 2019

AbstractObjectivesThe purpose of the study was to assess patients' postoperative discomfort after implantations according to the All‐on‐4 concept with and without using Zygoma implants.Material and methodsThree treatment groups were formed for this prospective study: All‐on‐4 rehabilitation in the maxilla (group 1, N = 25), All‐on‐4 rehabilitation in the maxilla using at least two Zygoma implants (group 2, N = 25), and All‐on‐4 rehabilitation in the mandible (group 3, N = 20). Principal outcome parameters were postoperative pain (100 mm VAS) and perceived swelling (100 mm VAS). Also, the use of analgesics was documented.ResultsThe worst postoperative pain of 21.3 (SD 18.9) VAS was observed in group 2, but there was no statistically significant difference between the groups (mixed ANOVA p = .791). The postoperative total intake of painkillers was significantly higher in group 2 than in the other groups (p < .001). On postoperative day 28, the mean pain scores in all groups declined to values below 5 VAS. Postoperative perceived swelling in group 2 was significantly more severe than it was in group 1 and 3 (p < .001).ConclusionsThe use of Zygoma implants in All‐on‐4 surgical interventions had an essential effect on postoperative swelling, but less so on postoperative pain. The slightly increased, but statistically not significantly different postoperative pain in group 2 was compensated by an overall higher postoperative intake of painkillers compared to the other groups.
Ablation of striatal somatostatin interneurons affects MSN morphology and electrophysiological properties, and increases cocaine‐induced hyperlocomotion in mice
Authors: Gazan Adeline , Rial Daniel , Schiffmann Serge N. 
Published: September 2019

AbstractThe striatum is mainly composed by medium spiny neurons (95 %) (MSNs). Although outnumbered, in other brain regions such as the hippocampus and the cortex, somatostatin interneurons (SSTi) are known to control and fine‐tune the activity of principal cells. This information is still fragmented for the striatum. Here, we questioned the striatal functional consequences of the selective ablation of SSTi in the striatum at the behavioural and cellular levels. We identified increased excitability coupled with decreased distal spine density in MSNs from SSTi‐ablated mice. Although the ethological behavioural analysis did not reveal differences between the groups, SSTi‐ablated mice were significantly more sensitive to the locomotor effects of cocaine without changes in motivation. This was accompanied by increased expression of the dopamine transporter (DAT) in the ventral striatum. Altogether, we show that SSTi are important players in the maintenance of MSN excitability and spine density impacting on mechanisms towards hyperdopaminergic states.