bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of the Toulon-Verona Conference Excellence in Services best papers 2008-2016
Authors: Papadimitriou Antigoni 
Published: April 2018

Purpose
The purpose of this paper is to review and explore the primary characteristics of the best papers, which have been selected by the Toulon-Verona Conference (TVC) Excellence in Services scientific committee for the period 2008-2016.

Design/methodology/approach
The study includes a review of the best papers (n = 51) selected by the TVC’s scientific committee from 2008 to 2016 and obtained through the TVC’s archives. The primary highlights of each paper include number of authors, authorship profile (i.e. lead author affiliation, gender, and geographic location), co-authors’ geographic locations, classification of the papers, research topics, varieties of research methods used, number of electronic downloads (as of June 2017), number of citations, and subject keywords. Coding sheet developed to ensure standardization, consistency and to ensure the relevant data were collected for the content analysis. Mixed methods analysis (analyze quantitative data qualitative and and vice versa) was used to provide descriptive statistics.

Findings
In total, 51 best papers have been selected by the TVC scientific committee and reflected 145 authors. Lead authors were from a total of 50 HEIs worldwide and one consultant (private sector). Six papers were self-authored while the 45 were multi-authored. The majority of the papers written by Italian authors (58.8 percent); followed by France, Greece, and Sweden (5.9 percent each); Australia, Portugal, Spain, and UK (4 percent each); Austria, Norway, Slovenia, and Vietnam (1.9 percent each). In total, 37 papers were classified as a research paper, 10 case studies, and 4 theoretical.

Practical implications
The analysis for the first time define methodological trends for the TVC’s best papers and suggest possible future research topic and methodological approach for research in the management field.

Originality/value
The findings are unique for the TVC conference, for the TQM’s special issue, which provide practical implications for researchers and conference organizers and contribute to the literature of analyzing published papers.
A child's day: trends in time use in the UK from 1975 to 2015
Authors: Mullan Killian 
Published: April 2018

AbstractThis paper examines change in school‐age children’s (8–16 years) time use in the United Kingdom between 1975 and 2015. Over this period, concerns for children’s safety, technological change, and increased emphasis on success in school are widely argued to have altered children’s daily lives, leading for example to less time outdoors, more time in screen‐based activities, and more time focused on education. Using data from three national time use surveys collected in 1974–5, 2000–01 and 2014–15, this paper explores the extent to which these arguments reflect actual change in how children spend their time throughout the day. The results show that between 1975 and 2015 children increased their time at home, and spent more time in screen‐based activities and doing homework. Decreases in time in out‐of‐home activities were concentrated in time in unstructured play, partially offset by increased time in sport. A decomposition of trends revealed that, despite a narrowing of the gender gap in time in housework, gender remains a significant factor determining many aspects of children’s time use. In contrast, the significance of age declined in most leisure activities, with the exception of screen‐based activities where significant age differences emerged in 2000 and widened further in 2015.
Academic performance of third‐year medical students learning in rural settings
Authors: Wyatt Janine E. , Chater Alan Bruce 
Published: April 2018

AbstractObjectiveInvestigate the academic performance of medical students in rural and remote discipline rotations by rurality of placement.DesignA retrospective cohort study.SettingRural and remote clinical placement locations in Queensland, Australia.ParticipantsUniversity of Queensland third‐year medical students.Main outcome measuresIn this study, student results for a range of assessments are the main outcome measures with rural area of student placement locations as categorised by the Australian Standard Geographical Classification – Remoteness Areas system the independent variable of interest.ResultsThere was a significant effect of Australian Standard Geographical Classification – Remoteness Areas of placement on the health project, clinical case presentation, clinical participation assessment and overall grade, after controlling for the potential confounding impact of sex, age, students who attended the rural clinical school, cohort year, rotation during the year and type of health service where students were placed. No significant effect of rural placement level was identified for the written examination, poster or journal of achievement assessments.ConclusionMedical students’ academic achievement is associated with many factors, but this study shows that being placed in remote areas is one factor that either does not impede or can positively influence the learning and academic performance of medical students.
Development problems were common five years after positive screening for language disorders and, or, autism at 2.5 years of age
Authors: Miniscalco Carmela , Fernell Elisabeth , Thompson Lucy , Sandberg Eva , Kadesjö Björn , Gillberg Christopher 
Published: April 2018

AbstractAimThis study identified whether children who had screened positive for either developmental language disorder (DLD) or autism spectrum disorder (ASD) at the age of 2.5 years had neurodevelopmental assessments five years later.MethodsOur study cohort were 288 children born from 1 July 2008 to 20 June 2009 who screened positive for DLD and, or, ASD at 2.5 years. Of these, 237 children were referred to, and assessed, at the Paediatric Speech and Language Pathology clinic (n = 176) or the Child Neuropsychiatry Clinic (n = 61) at the Queen Silvia Children's Hospital, Gothenburg, Sweden. Clinical registers covering all relevant outpatient clinics were reviewed five years later with regard to established diagnoses.ResultsWhen the 237 were followed up five years later, 96 (40%) had established neurodevelopmental disorders or problems, often beyond DLD and ASD. Co‐existing problems were common in this cohort and multidisciplinary assessments were indicated. The other 60% did not appear in subsequent clinic records. It is likely that this 40% was a minimum rate and that more children will be referred for developmental problems later.ConclusionFive years after they had been screened positive for DLD and, or autism at 2.5 years, 40% of our cohort had remaining or other developmental problems.
Treatment of acute lymphoblastic leukaemia with the second generation of CD19 CAR‐T containing either CD28 or 4‐1BB
Authors: Li Shiqi , Zhang Jiasi , Wang Meiling , Fu Gang , Li Yunyan , Pei Li , Xiong Zhouxing , Qin Dabing , Zhang Rui , Tian Xiaobo , Wei Zhihao , Chen Run , Chen Xuejiao , Wan Jia , Chen Jun , Wei Xia , Xu Yanmin , Zhang Pei , Wang Ping , Peng Xi , Yang Sainan , Shen Junjie , Yang Zhi , Chen Jieping , Qian Cheng 
Published: April 2018

AbstractT cells modified with anti‐CD19 chimeric antigen receptor (CAR) containing either CD28 or 4‐1BB (also termed TNFRSF9, CD137) costimulatory signalling have shown great potential in the treatment of acute lymphoblastic leukaemia (ALL). However, the difference between CD28 and 4‐1BB costimulatory signalling in CAR‐T treatment has not been well elucidated in clinical trials. In this study, we treated 10 relapsed or refractory ALL patients with the second generation CD19 CAR‐T. The first 5 patients were treated with CD28‐CAR and the other 5 patients were treated with 4‐1BB CAR‐T. All the 10 patients were response‐evaluable. Three patients achieved complete remission and 1 patient with extramedullary disease achieved partial response after CD28‐CAR‐T treatment. In the 4‐1BB CAR‐T treatment group, 3 patients achieved complete remission. Furthermore, FLT‐3 ligand (FLT3LG) was highly correlated with response time and may serve as a prognosis factor. No severe adverse events were observed in these 10 treated patients. Our study showed that both CD28 CAR‐T and 4‐1BB CAR‐T both worked for response but they differed in response pattern (peak reaction time, reaction lasting time and reaction degree), adverse events, cytokine secretion and immune‐suppressive factor level.
Overrated hedonic judgment of odors in patients with schizophrenia
Authors: Urban‐Kowalczyk Małgorzata , Śmigielski Janusz , Kotlicka‐Antczak Magdalena 
Published: April 2018

SummaryAimsThe odor identification ability and its hedonic judgment in patients with schizophrenia were evaluated in the study. The association between olfactory performance and negative symptoms and β‐endorphin concentration was also analyzed.MethodsStudy groups consisted of 23 patients with negative symptoms (PN) and 25 without predominant negative symptoms (PP) and 21 healthy individuals. The University of Pennsylvania Smell Identification Test, odor hedonic evaluation, and plasma concentrations of β‐endorphin assay in all participants were performed.ResultsPN perceived the poorer olfactory identification; nevertheless, they evaluated unpleasant odors as more pleasant than PP and controls. Beta‐endorphin concentration was significantly higher among PN than in other study groups. No association was observed between β‐endorphin and odors identification and odor hedonic judgment among all study groups.ConclusionsThere is potential relationship between increased β‐endorphin concentration and severity of negative symptoms. Patients with predominant negative symptoms tend to evaluate odors as significantly more pleasant. Individuals with this subtype of schizophrenia might present specific, altered pattern of smell identification and hedonic judgment. Presumably, β‐endorphin has no direct influence on olfactory identification performance and hedonic judgment in schizophrenia.
Activation of T cells by dendritic cells exposed to a reference sensitizer: Towards a promising model to assess the allergenic potential of chemicals
Authors: Huppert Cécile , Paris Christophe , Langonné Isabelle , Muller Samuel , Mathiot Julianne , Abdessadeq Hakima , Gagnaire François , Battais Fabrice , Sponne Isabelle 
Published: April 2018

BackgroundLow molecular weight chemicals constitute one of the major causes of occupational allergies. European legislation on chemicals recommends limiting the use of in vivo models for assessing the sensitizing potential of chemicals, and encourages the development of integrated alternative methods. An in vitro mouse model of bone marrow‐derived dendritic cells (BMDCs) that showed good accuracy (75%) and sensitivity (69%) has previously been developed to assess the sensitizing potential of chemicals.ObjectiveTo assess the ability of BMDCs to activate T cells (TCs) in vitro.MethodsBMDCs pre‐exposed to the reference sensitizer ammonium hexachloroplatinate (AHCP) were co‐cultured with different subpopulations of TCs. TC activation was assessed by surface marker expression, proliferation, and cytokine release.ResultsThe results showed significant activation of TCs co‐cultured with dendritic cells pre‐exposed to AHCP as evaluated by CD124 expression, proliferation, and cytokine secretion. Moreover, the response of TCs appeared to be Th2‐oriented. Naive TCs were shown to be involved in this response, and the removal of regulatory TCs did not improve the cell response.ConclusionsThe BMDCs used in this previously developed model appear to have the ability to activate TCs, confirming that the BMDC model represents a reliable assay for assessing the sensitizing potential of chemicals.
The market for independent directors
Authors: Chen Lei , Moers Frank 
Published: April 2018

AbstractManuscript TypeEmpiricalResearch Question/IssueUsing the US setting from 1996 to 2006, we examine how the market for independent directors responds to increasingly stringent scrutiny.Research Findings/InsightsDespite the unambiguous increase in the demand for independent directors (with financial expertise) since 2000, independent directors (with financial expertise) have not expanded their board seats but reduced them. Incumbents are more likely to depart from firms that are costly to advise and monitor, but only post‐2000. Meanwhile, we document an influx of new directors to the labor market. These new directors are more likely to be hired by firms that are costly to advise and monitor post‐2000 and are more likely to be financial experts so that the increased demand can be satisfied.Theoretical/Academic ImplicationsWe provide evidence that the demand–supply framework adequately captures the market for independent directors. In particular, rather than the demand effect simply dominating the supply effect for a particular group of directors, the demand is fulfilled by opposing supply effects of different types of directors, specifically incumbents versus new entrants.Practitioner/Policy ImplicationsPolicy makers should not underestimate the (dis)incentives that directors have to provide services to the market when initiating future governance reforms (e.g. writing the limit on the number of directorships held by directors into best practice/law). Firms, especially ones that are costly for directors to advise and monitor, are encouraged to explore effective ways to retain valuable directors and prepare thorough succession plans whenever the supply of directors is expected to shrink.
The impact of transarterial chemoembolization induced complications on outcomes after liver transplantation: A propensity‐matched study
Authors: Boteon Amanda Pinter Carvalheiro da Silva , Boteon Yuri Longatto , Vinuela Eduardo F. , Derosas Carlos , Mergental Hynek , Isaac John R. , Muiesan Paolo , Mehzard Homoyoon , Ma Yuk Ting , Shah Tahir , Mirza Darius F. , Perera M. Thamara P. R. 
Published: April 2018

AbstractBackgroundLoco‐regional complications of transarterial chemoembolization (TACE) may adversely affect technical aspects of the liver transplantation (LT). This study reviewed the impact of those complications on postoperative outcomes encompassing implications on graft selection.MethodsA retrospective, propensity score matching (1:1) analysis accounting for donor and recipient confounders was performed on a dataset of patients undergoing LT for hepatocellular carcinoma. Outcomes of patients who had TACE (TACE‐group) were compared with those who did not (NoTACE‐group).ResultsA total of 57 matched pairs were analyzed. TACE achieved effective tumor control (Pre‐TACE vs Post‐TACE; Median: 44 mm [interquartile range: 43‐50] vs 17 mm [0‐36]; P = .002) on imaging follow‐up. TACE group had, at the hepatectomy, higher incidence of ischemia‐related complications (adhesions of the necrotic tumor, cholecystitis, and/or bile duct necrosis) (40.4% vs 10.5%; P = .001). Overall major post‐LT complications rate (Dindo‐Clavien ≥3) were similar (P = .134). Those in the TACE group with donors after circulatory death (DCD) had 4.6% 90‐day mortality and 54.3% major complication rate compared to 6.9% and 77.3% (P = .380 and P = .112, respectively).ConclusionTACE was an effective bridging procedure that may complicate LT inducing ischemic‐related complications; nevertheless, it has not shown repercussions on mortality or morbidity after the procedure, even using donors after circulatory death.
Initial Clinical Experience of RP5063 Following Single Doses in Normal Healthy Volunteers and Multiple Doses in Patients with Stable Schizophrenia
Authors: Cantillon Marc , Ings Robert , Bhat Laxminarayan 
Published: April 2018

AbstractRP5063 is a multimodal dopamine (D)‐serotonin (5‐HT) stabilizer with a high affinity for D2/3/4 and 5‐HT1A/2A/2B/7 receptors and moderate affinity for the serotonin transporter. Single‐dose (10 and 15 mg fasting, 15 mg fed) safety in healthy volunteers and multiple‐dose (10, 20, 50, and 100 mg fed, 10 days) safety and pharmacodynamics in patients with stable schizophrenia were defined in two phase I studies. In the single‐dose study, 32 treatment‐emergent adverse events (TEAEs) were observed. Orthostatic hypotension (n = 6), nausea (n = 5), and dizziness (n = 4) were the most common. One serious adverse event (SAE), seen in a patient who should not have been in the study due to a history of seizures, involved brief seizure‐like symptoms. In the multiple‐dose study, 75 TEAEs were reported. Akathisia (n = 20) and somnolence (n = 14) were the most frequent. No clinically significant changes were seen in glucose or prolactin levels, lipid profiles, weight, or electrocardiographic recordings. In both studies, all TEAEs resolved and none led to withdrawal from the study or death. A pharmacodynamic evaluation reflected significant improvements with RP5063 (P < 0.05) over placebo in an analysis of patients with a baseline Positive and Negative Syndrome Scale (PANSS) score ≥50 for positive subscale scores. Improvements of the Trail Making A and Trail Making B test results were observed for patients treated in the 50 mg dose group for days 5, 10, and 16. These findings indicate that RP5063 is well‐tolerated up to 100 mg and displays promising preliminary clinical behavioral and cognition activity signals in patients with stable disease over a 10‐day period.
Imaging findings associated with nasopharyngeal amyloidosis in an Arabian stallion
Authors: Russell L. A. , Navas de Solis C. , Whitfield‐Cargile C. M. , Deveau M. A. , Buchanan B. R. , Gilmour L. J. 
Published: April 2018

SummaryA 3‐year‐old Arabian stallion presented for imaging and further work‐up of nasal discharge and respiratory stridor secondary to nasal amyloidosis. Thickening of the nasal mucosa with heterogeneous attenuation of the affected tissues was identified on CT images. The nasal mucosa, mucosa of the arytenoid cartilages, and regional lymph nodes were hypointense on T2 and T1 MRI images with moderate, patchy contrast enhancement. Biopsy and histopathology of the nasal mucosa, mucosa of the arytenoid cartilages and regional lymph nodes confirmed the original diagnosis of amyloidosis. Six fractions of helical tomotherapy did not provide significant improvement in respiratory effort, and permanent tracheostomy was performed. Haemorrhagic nasal discharge and mucosal plaques in the nasal cavity, pharynx, larynx, and trachea worsened over a 19‐month interim. This paper offers the first description of the CT and MRI findings of nasopharyngeal amyloidosis in a horse, and the first description of the use of helical tomotherapy in an equine patient.
The group VIA calcium‐independent phospholipase A2 and NFATc4 pathway mediates IL‐1β‐induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts
Authors: Kuwata Hiroshi , Yuzurihara Chihiro , Kinoshita Natsumi , Taki Yuki , Ikegami Yuki , Washio Sana , Hirakawa Yushi , Yoda Emiko , Aiuchi Toshihiro , Itabe Hiroyuki , Nakatani Yoshihito , Hara Shuntaro 
Published: April 2018

Chemokines are secreted proteins that regulate cell migration and are involved in inflammatory and immune responses. Here, we sought to define the functional crosstalk between the lipid signaling and chemokine signaling. We obtained evidence that the induction of some chemokines is regulated by group VIA calcium‐independent phospholipase A2β (iPLA2β) in IL‐1β‐stimulated rat fibroblastic 3Y1 cells. Treatment of 3Y1 cells with IL‐1β elicited an increased release of chemotactic factor(s) for monocytic THP‐1 cells into culture medium in a time‐dependent manner. Inhibitor studies revealed that an intracellular PLA2 inhibitor, arachidonoyl trifluoromethyl ketone (AACOCF3), but not the cyclooxygenase inhibitor indomethacin, attenuated the release of chemotactic factor(s). The chemotactic activity was inactivated by treatment with either heat or proteinase K, suggesting this chemotactic factor(s) is a proteinaceous factor(s). We purified the chemotactic factor(s) from the conditioned medium of IL‐1β‐stimulated 3Y1 cells using a heparin column and identified several chemokines, including CCL2 and CXCL10. The inducible expressions of CCL2 and CXCL10 were significantly attenuated by pretreatment with AACOCF3. Gene silencing using siRNA revealed that the inductions of CCL2 and CXCL10 were attenuated by iPLA2β knockdown. Additionally, the transcriptional activation of nuclear factor of activated T‐cell proteins (NFATs), but not nuclear factor‐κB, by IL‐1β stimulation was markedly attenuated by the iPLA2 inhibitor bromoenol lactone, and NFATc4 knockdown markedly attenuated the IL‐1β‐induced expression of both CCL2 and CXCL10. Collectively, these results indicated that iPLA2β plays roles in IL‐1β‐induced chemokine expression, in part via NFATc4 signaling.
A Tutorial on the Practical Use and Implication of Complete Sufficient Statistics
Authors: Hermans Lisa , Molenberghs Geert , Aerts Marc , Kenward Michael G. , Verbeke Geert 
Published: April 2018

SummaryCompleteness means that any measurable function of a sufficient statistic that has zero expectation for every value of the parameter indexing the parametric model class is the zero function almost everywhere. The property is satisfied in many simple situations in view of parameters of direct scientific interest, such as in regression models fitted to data from a random sample with fixed size. A random sample is not always of a fixed,a prioridetermined size. Examples include sequential sampling and stopping rules, missing data and clusters with random size. Often, there then is no complete sufficient statistic. A simple characterisation of incompleteness is given for the exponential family in terms of the mapping between the sufficient statistic and the parameter, based upon the implicit function theorem. Essentially, this is a comparison of the dimension of the sufficient statistic with the length of the parameter vector. This results in an easy verifiable criterion for incompleteness, clear and simple to use, even for complex settings as is shown for missing data and clusters of random size.This tutorial exemplifies the (in)completeness property of a sufficient statistic, thereby illustrating our proposed characterisation. The examples are organised from more classical, simple examples to gradually more advanced settings.
Dissection of the genetic architecture of rice resistance to Xanthomonas oryzae pv. oryzae using a genomewide association study
Authors: Li Chenggang , Su Pin , Wang Dan , Peng Shasha , Chen Yue , Chen Jianbin , Tan Xinqiu , Zhang Deyong , Wang Guo‐Liang , Liu Yong 
Published: April 2018

AbstractBacterial blight, caused by Xanthomonas oryzae pv. oryzae (Xoo), usually causes serious rice yield loss in many countries. Rice breeders have used resistance (R) genes to control the disease but many of the resistant cultivars become susceptible few years after releasing. Identification of new R genes to Xoo is one of the main objectives in rice breeding programs. In this study, we used a genomewide association study (GWAS) to analyse the resistance against the Xoo race C1 using the Rice Diversity Panel 1 (RDP1). Disease evaluation of the RDP1 population to C1 indicated that the AUS subgroup conferred a higher level of resistance to C1 than other subgroups. Genomewide association mapping identified 15 QTLs that are distributed on chromosomes 1, 2, 3, 4, 5, 6, 8, 9, 10 and 12. Some of them are located in the regions without known resistance loci or QTLs. This study demonstrated the effectiveness of GWAS on the genetic dissection of rice resistance to Xoo and provided many Xoo resistance‐associated SNP markers for rice breeding.