bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Transformation of the Rehabilitation Paradigm Across the Continuum of Care
Authors: Watanabe Thomas K. , Esquenazi Alberto , Flanagan Steven 
Published: September 2018

AbstractAs healthcare continues to evolve, there are changes in the delivery of care for patients with severe neurologic injuries. Although the acute hospital stay is shortening, physiatrists can play a key role in preparing patients for rehabilitation, minimizing longer‐term complications and helping to determine the most appropriate paths for further treatment. Inpatient rehabilitation facilities (IRFs) continue to be an important part of the care continuum for patients with severe injuries, but the role of IRFs has also evolved as patients have been admitted with increasing medical and neurologic complexity and length of stay continues to be reduced. Skilled nursing facilities and subacute facilities continue to evolve, in part to fill the gaps that have developed for patients who are “not yet ready for rehabilitation” and for those whose recovery trajectory has been deemed too slow for IRF. Outpatient care is also changing, in part due to the availability of new rehabilitation interventions as highlighted in other sections of the supplement. Furthermore, telemedicine will provide additional options for expanding specialized care beyond prior geographical limitations. Physiatrists need to be aware of these ongoing changes and the roles that they can play outside of the traditional IRF model of care. This article will focus on the innovations in healthcare delivery and opportunities to maximize outcomes in the current and future models of care.
How robust is the renewable energy industry to political shocks? Evidence from the 2016 U.S. elections
Authors: Aklin Michaël 
Published: September 2018

AbstractClimate change mitigation relies increasingly on clean technologies such as renewable energy. Despite widespread success, further deployment of renewables has been met with resistance from voters and governments in several countries. How resilient is the renewable energy industry to adverse political events? I use the unexpected election of Donald Trump in the 2016 U.S. presidential race to study this question. As a vocal critic of renewables and a supporter of fossil fuels, his election is a plausible negative shock to the renewable energy sector. I examine stock market data to gauge the reaction of investors. I find that renewable energy stocks were adversely affected by the election. Overall, they experienced a cumulative abnormal loss in share values of about 6 percent on average over the twenty days that followed the election. However, I find that the negative effect is concentrated among non-U.S. firms. U.S. firms, on average, emerged unscathed. Non-U.S. companies, on the other hand, lost over 14 percent of their value in the aftermath of the election. This suggests that markets are more concerned by increasing obstacles to international business than a decrease of federal support for renewables.
Legislating intersex equality: building the resilience of intersex people through law
Authors: Garland Fae , Travis Mitchell 
Published: September 2018

AbstractThis paper presents the findings from the first qualitative study to consider the relationship between intersex experience and law, representing a significant contribution to a currently under-researched area of law. Since 2013 there has been a global move towards the legal recognition of intersex, with Australia, Germany and Malta all using different techniques to construct and regulate intersex embodiment. This paper is the first to compare and problematise these differing legal approaches in the legal literature. In doing so it demonstrates that many of these approaches are grounded in ideas of formal equality that lead to the entrenchment of vulnerability and fail to build resilience for the intersex community. Through engagement with the intersex community a more contextual account of substantive equality is enabled, encouraging new approaches to law and social justice. Our qualitative study revealed that prevention of non-therapeutic medical interventions on the bodies of children was understood to be the key method to achieving equality for intersex embodied people. Whilst this is the cornerstone of intersex-led legislative reform, such an approach necessitates support through a mixture of formal and substantive equality methods such as anti-discrimination law, education and enforcement procedures. This paper concludes by offering a series of recommendations to legislators capable of enabling substantive intersex equality.
When Reporting Undermines Performance: The Costs of Politically Constrained Organizational Autonomy in Foreign Aid Implementation
Authors: Honig Dan 
Published: September 2018

AbstractBureaucracies with field operations that cannot be easily supervised and monitored by managers are caught between two sources of dysfunction that may harm performance. The first source of dysfunction is straightforward: field workers can use operating slack and asymmetric information to their own advantage, thwarting an organization's objectives. The second source of dysfunction is often overlooked: attempts to limit workers’ autonomy may have deleterious effects, curbing agents’ ability to respond efficaciously to the environment. I find that the parliaments and executive boards to whom International Development Organizations (IDOs) are accountable differentially constrain IDO organizational autonomy, which in turn affects management's control of field agents. Tight management control of field agents has negative effects, particularly in more unpredictable environments. Attempts by politicians to constrain organizations in an effort to improve performance can sometimes be self-undermining, having net effects opposite those intended.
Ecological priming of artificial aquaculture structures: kelp farms as an example
Authors: Walls AM , Edwards MD , Firth LB , Johnson MP 
Published: September 2018

AbstractThe continued development of the aquaculture industry is contributing to the proliferation of artificial structures in the marine environment. Observations of seaweed farms (infrastructure and biomass) suggest they act as a habitat for associated species. Seaweed farms differ from other forms of artificial infrastructure as the material deployed already has marine organisms (i.e. culture species) growing on it. This ‘priming’ of ropes with juvenile sporophytes may affect future development of communities by facilitating colonizing species or suppressing competitors. We call this process ‘ecological priming’: the provision of a biological platform that influences the successional development of specific communities. The communities that developed on ropes primed with Alaria esculenta individuals were compared with unprimed ropes to assess the ecological priming effect, at a commercial kelp farm in south-west Ireland. Species richness increased over two cultivation seasons and species composition was consistent between years, with distinct communities developing on primed and unprimed treatments. Timing of species occurrence on primed ropes was predictable with no predictable pattern occurring on unprimed ropes. Multivariate tests indicated distinct communities between treatments, with suppression of other algal species and potential facilitation of some species that have a particular association with A. esculenta on primed ropes. Communities from primed holdfasts contained a lower diversity of algal species compared with unprimed communities. Cultivated kelp holdfasts represent a habitat for distinct assemblages that reflect ecological priming of the substratum.
Unpacking the link between socioeconomic status and behavior problems: A second-order meta-analysis
Authors: Korous Kevin M. , Causadias José M. , Bradley Robert H. , Luthar Suniya S. 
Published: September 2018

AbstractSubstantial evidence links socioeconomic status to internalizing and externalizing behavior problems. However, it is unclear how these two categories of behavior problems relate to specific components of socioeconomic status (e.g., income, educational attainment, and occupational prestige) or overall social status. In this study, we conducted a second-order meta-analysis to estimate the average associations of income, education, occupation, and overall socioeconomic status with internalizing and externalizing behavior problems, and to examine if age, sex, and race/ethnicity moderated these associations. Our systematic search in PsycINFO, PubMed, Google Scholar, Web of Science, and ProQuest Dissertations and Theses Global identified 12 meta-analyses (17% unpublished), including approximately 474 primary studies and 327,617 participants. In relation to internalizing, we found small average associations with income, r+ = –.18, 95% confidence interval (CI) [–.31, –.04], and education, r+ = –.12, 95% CI [–.15, –.09]. In relation to externalizing, we found smaller associations with income, r+ = –.02, 95% CI [–.15, .10], education, r+ = –.03, 95% CI [–.16, .10], and overall socioeconomic status, r+ = –.05, 95% CI [–.11, .01], but these CIs included zero. Only sex composition of the samples moderated the latter association. We provide recommendations for best practices and future research directions.
COMPLETENESS OF SECOND-ORDER PROPOSITIONAL S4 AND H IN TOPOLOGICAL SEMANTICS
Authors: KREMER PHILIP 
Published: September 2018

AbstractWe add propositional quantifiers to the propositional modal logic S4 and to the propositional intuitionistic logic H, introducing axiom schemes that are the natural analogs to axiom schemes typically used for first-order quantifiers in classical and intuitionistic logic. We show that the resulting logics are sound and complete for a topological semantics extending, in a natural way, the topological semantics for S4 and for H.
Paleointensity Estimates From Ignimbrites: The Bishop Tuff Revisited
Authors: Avery Margaret S. , Gee Jeffrey S. , Bowles Julie A. , Jackson Michael J. 
Published: September 2018

AbstractVolcanic ash flow tuffs (ignimbrites) may contain single domain‐sized (titano) magnetite that should be good for recording geomagnetic field intensity, but due to their complex thermal histories also contain other magnetic grains, which can complicate and obscure paleointensity determination. An initial study of the suitability of the ~767 ka Bishop Tuff for measuring paleointensity found an internally consistent estimate of 43.0 ± 3.2 μT. This initial study also showed a spatial heterogeneity in reliable paleointensity estimates that is possibly associated with vapor‐phase alteration and fumarolic activity, which motivated resampling of the Bishop Tuff to examine spatial changes in magnetic properties. Three new stratigraphic sections of the Bishop Tuff within the Owens River gorge were sampled, and the paleointensity results from the initial study in the same locality were reinterpreted. The mean of all sites is 41.9 ± 11.8 μT; this agrees with the initial study's finding but with substantially greater scatter. Two sections show evidence of vapor‐phase alteration where the presence of titanohematite, likely carrying a thermochemical remanence, produces nonideal behavior. This thermochemical remanence in the upper portion of the section also produces some paleointensity estimates of technically high quality that have significantly higher intensity than the rest of the tuff. Our best estimate for paleointensity, 39.6 ± 9.9 μT, comes from the densely welded ignimbrite that was emplaced above the Curie temperature of magnetite. The low permeability of this unit likely shielded it from vapor‐phase alteration. Our results suggest that care must be taken in interpreting paleointensity data from large tuffs as nonthermal remanence may be present.
Constraining Aerosol Vertical Profile in the Boundary Layer Using Hyperspectral Measurements of Oxygen Absorption
Authors: Zeng Zhao‐Cheng , Natraj Vijay , Xu Feng , Pongetti Thomas J. , Shia Run‐Lie , Kort Eric A. , Toon Geoffrey C. , Sander Stanley P. , Yung Yuk L. 
Published: September 2018

AbstractThis study attempts to infer aerosol vertical structure in the urban boundary layer using passive hyperspectral measurements. A spectral sorting technique is developed to retrieve total aerosol optical depth (AOD) and effective aerosol layer height (ALH) from hyperspectral measurements in the 1.27‐μm oxygen absorption band by the mountaintop Fourier Transform Spectrometer at the California Laboratory for Atmospheric Remote Sensing instrument (1,673 m above sea level) overlooking the LA basin. Comparison to AOD measurements from Aerosol Robotic Network and aerosol backscatter profile measurements from a Mini MicroPulse Lidar shows agreement, with coefficients of determination (r2) of 0.74 for AOD and 0.57 for effective ALH. On average, the AOD retrieval has an error of 24.9% and root‐mean‐square error of 0.013, while the effective ALH retrieval has an error of 7.8% and root‐mean‐square error of 67.01 m. The proposed method can potentially be applied to existing and future satellite missions with hyperspectral oxygen measurements to constrain aerosol vertical distribution on a global scale.
Upper Mantle Seismic Structure of Alaska From Rayleigh and S Wave Tomography
Authors: Jiang Chengxin , Schmandt Brandon , Ward Kevin M. , Lin Fan‐Chi , Worthington Lindsay L. 
Published: September 2018

AbstractMantle shear velocity (Vs) structure beneath the Transportable Array (TA) in Alaska and northwestern Canada is imaged by joint inversion of Rayleigh wave dispersion and teleseismic S wave travel times. The study connects previously unsampled parts of northern and western Alaska with portions of southern Alaska imaged with earlier seismic arrays. The new Vs tomography shows contrasting lithospheric structure in the plate interior with lower Vs shallow upper mantle indicative of thinner thermal lithosphere south of the Brooks Range and along the transform margin. Higher Vs down to ~200 km beneath the Brooks Range and northern coast is consistent with the presence of a cold stable lithospheric root that may help guide intraplate deformation to the south. In the subduction‐to‐transform transition, a potential slab fragment is imaged beneath the Wrangell volcanic field where modern subduction has slowed due to the thick buoyant crust of the Yakutat terrane.
Lapse Rate or Cold Point: The Tropical Tropopause Identified by In Situ Trace Gas Measurements
Authors: Pan Laura L. , Honomichl Shawn B. , Bui Thaopaul V. , Thornberry Troy , Rollins Andrew , Hintsa Eric , Jensen Eric J. 
Published: September 2018

AbstractAlthough the tropopause is a well‐established concept, its definition and physical properties remain an active research topic. In the tropics, both the World Meteorological Organization established lapse rate tropopause definition and the minimum in the temperature profile (the cold point) are used to determine the tropopause height. We examine the differences produced by these two definitions using high‐resolution airborne in situ measurements of temperature, water vapor, and ozone in the tropical tropopause layer from a recent experiment over the western Pacific using the National Aeronautics and Space Administration (NASA) Global Hawk unmanned aircraft system. When the two definitions do not produce the same tropopause height, which is in about half of the cases, the combined temperature and trace gas analysis shows that the lapse rate definition better identifies the transition from the troposphere to the stratosphere.
Automatic Classification of Volcano Seismic Signatures
Authors: Malfante Marielle , Dalla Mura Mauro , Mars Jerome I. , Métaxian Jean‐Philippe , Macedo Orlando , Inza Adolfo 
Published: September 2018

AbstractThe prediction of volcanic eruptions and the evaluation of associated risks remain a timely and unresolved issue. This paper presents a method to automatically classify seismic events linked to volcanic activity. As increased seismic activity is an indicator of volcanic unrest, automatic classification of volcano seismic events is of major interest for volcano monitoring. The proposed architecture is based on supervised classification, whereby a prediction model is built from an extensive data set of labeled observations. Relevant events should then be detected. Three steps are involved in the building of the prediction model: (i) signals preprocessing, (ii) representation of the signals in the feature space, and (iii) use of an automatic classifier to train the model. Our main contribution lies in the feature space where the seismic observations are represented by 102 features gathered from both acoustic and seismic fields. Ideally, observations are separable in the feature space, depending on their class. The architecture is tested on 109,609 seismic events that were recorded between June 2006 and September 2011 at Ubinas Volcano, Peru. Six main classes of signals are considered: long‐period events, volcanic tremors, volcano tectonic events, explosions, hybrid events, and tornillos. Our model reaches 93.5% ± 0.50% accuracy, thereby validating the presented architecture and the features used. Furthermore, we illustrate the limited influence of the learning algorithm used (i.e., random forest and support vector machines) by showing that the results remain accurate regardless of the algorithm selected for the training stage. The model is then used to analyze 6 years of data.
Keratin 80 promotes migration and invasion of colorectal carcinoma by interacting with PRKDC via activating the AKT pathway
Authors: Li Changcan , Liu Xisheng , Liu Yuan , Liu Xueni , Wang Rangrang , Liao Jianhua , Wu Shaohan , Fan Junwei , Peng Zhihai , Li Bin , Wang Zhaowen 
Published: September 2018

AbstractLittle is known about the function of Keratin 80 (KRT80), an epithelial keratin, in cancer. This study investigated the role of KRT80 in the prognosis of colorectal carcinoma (CRC) and the underlying mechanisms involved in CRC migration and invasion. We analyzed the expression of KRT80 using The Cancer Genome Atlas and Oncomine databases. Higher expression of KRT80 was found to be significantly associated with multiple pathological parameters, lower disease-free survival, and overall survival in CRC patients. Also, KRT80 was an independent prognostic indicator for CRC. Furthermore, altered KRT80 expression impacted migration and invasion of CRC cells, as well as the expression of epithelial–mesenchymal transition (EMT)-related markers and cell morphology via the AKT pathway. Inhibiting the expression of AKT could reverse these phenomena. Liquid Chromatograph Mass Spectrometer/Mass Spectromete, Co-immunoprecipitation, and laser scanning confocal microscopy techniques showed that KRT80 could interact with protein kinase, DNA-activated, catalytic polypeptide (PRKDC). Suppressing PRKDC could inhibit the expression of AKT and EMT, as well as the migration and invasion of CRC cells. Taken together, these results demonstrated that KRT80 was an independent prognostic biomarker for CRC and promoted CRC migration and invasion by interacting with PRKDC via activation of the AKT pathway.
A new signaling cascade linking BMP4, BMPR1A, ΔNp73 and NANOG impacts on stem-like human cell properties and patient outcome
Authors: Voeltzel Thibault , Flores-Violante Mario , Zylbersztejn Florence , Lefort Sylvain , Billandon Marion , Jeanpierre Sandrine , Joly Stéphane , Fossard Gaelle , Milenkov Milen , Mazurier Frédéric , Nehme Ali , Belhabri Amine , Paubelle Etienne , Thomas Xavier , Michallet Mauricette , Louache Fawzia , Nicolini Franck-Emmanuel , Caron de Fromentel Claude , Maguer-Satta Véronique 
Published: September 2018

AbstractIn a significant number of cases cancer therapy is followed by a resurgence of more aggressive tumors derived from immature cells. One example is acute myeloid leukemia (AML), where an accumulation of immature cells is responsible for relapse following treatment. We previously demonstrated in chronic myeloid leukemia that the bone morphogenetic proteins (BMP) pathway is involved in stem cell fate and contributes to transformation, expansion, and persistence of leukemic stem cells. Here, we have identified intrinsic and extrinsic dysregulations of the BMP pathway in AML patients at diagnosis. BMP2 and BMP4 protein concentrations are elevated within patients’ bone marrow with a BMP4-dominant availability. This overproduction likely depends on the bone marrow microenvironment, since MNCs do not overexpress BMP4 transcripts. Intrinsically, the receptor BMPR1A transcript is increased in leukemic samples with more cells presenting this receptor at the membrane. This high expression of BMPR1A is further increased upon BMP4 exposure, specifically in AML cells. Downstream analysis demonstrated that BMP4 controls the expression of the survival factor ΔNp73 through its binding to BMPR1A. At the functional level, this results in the direct induction of NANOG expression and an increase of stem-like features in leukemic cells, as shown by ALDH and functional assays. In addition, we identified for the first time a strong correlation between ΔNp73, BMPR1A and NANOG expression with patient outcome. These results highlight a new signaling cascade initiated by tumor environment alterations leading to stem-cell features and poor patients’ outcome.
Modulation of intracellular calcium signaling by microRNA-34a-5p
Authors: Diener Caroline , Hart Martin , Alansary Dalia , Poth Vanessa , Walch-Rückheim Barbara , Menegatti Jennifer , Grässer Friedrich , Fehlmann Tobias , Rheinheimer Stefanie , Niemeyer Barbara A. , Lenhof Hans-Peter , Keller Andreas , Meese Eckart 
Published: September 2018

AbstractAdjusting intracellular calcium signaling is an important feature in the regulation of immune cell function and survival. Here we show that miR-34a-5p, a small non-coding RNA that is deregulated in many common diseases, is a regulator of store-operated Ca2+ entry (SOCE) and calcineurin signaling. Upon miR-34a-5p overexpression, we observed both a decreased depletion of ER calcium content and a decreased Ca2+ influx through Ca2+ release-activated Ca2+ channels. Based on an in silico target prediction we identified multiple miR-34a-5p target genes within both pathways that are implicated in the balance between T-cell activation and apoptosis including ITPR2, CAMLG, STIM1, ORAI3, RCAN1, PPP3R1, and NFATC4. Functional analysis revealed a decrease in Ca2+ activated calcineurin pathway activity measured by a reduced IL-2 secretion due to miR-34a-5p overexpression. Impacting SOCE and/or downstream calcineurin/NFAT signaling by miR-34a-5p offers a possible future approach to manipulate immune cells for clinical interventions.