bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphology, geographic distribution, and host preferences are poor predictors of phylogenetic relatedness in the mistletoe genus Viscum L
Authors: Maul Karola , Krug Michael , Nickrent Daniel L. , Müller Kai F. , Quandt Dietmar , Wicke Susann 
Published: October 2018

AbstractBesides their alleged therapeutic effects, mistletoes of the genus Viscum L. (Viscaceae) are keystone species in many ecosystems across Europe, Africa, Asia and Australia because of their complex faunal interactions. We here reconstructed the evolutionary history of Viscum based on plastid and nuclear DNA sequence data. We obtained a highly resolved phylogenetic tree with ten well-supported clades, which we used to understand the spatio-temporal evolution of these aerial parasites and evaluate the contribution of reproductive switches and shifts in host ranges to their distribution and diversification. The genus Viscum originated in the early Eocene in Africa and appeared to have diversified mainly through geographic isolation, in several cases apparently coinciding with shifts in host preferences. During its evolution, switches in the reproductive mode from ancestral dioecy to monoecy imply an important role in the long-distance dispersal of the parasites from Africa to continental Asia and Australia. We also observed multiple cases of photosynthetic surface reduction (evolution of scale leaves) within the genus, probably indicative of increasing specialization associated with the parasitic lifestyle. Even compared with other parasitic angiosperms, where more host generalists than specialists exist, Viscum species are characterized by extraordinarily broad host ranges. Specialization on only a few hosts from a single family or order occurs rarely and is restricted mostly to very recently evolved lineages. The latter mostly derive from or are closely related to generalist parasites, implying that niche shifting to a new host represents an at least temporary evolutionary advantage in Viscum.
Histone deacetylase activity is required for Botrylloides leachii whole body regeneration
Authors: Zondag Lisa , Clarke Rebecca , Wilson Megan J 
Published: October 2018

AbstractThe colonial tunicate Botrylloides leachii is exceptional at regenerating from a piece of vascular tunic after loss of all adults from the colony. Previous transcriptome analyses indicate a brief period of healing before regeneration of a new adult (zooid) in as little as 8–10 days. However, there is little understanding of how the resulting changes to gene expression, required to drive regeneration, are initiated and how the overall process is regulated. Rapid changes to gene expression often occur in response to chromatin changes, mediated by histone modifications such as histone acetylation. Here, we investigated a group of key epigenetic modifiers, histone deacetylases (HDAC) that are known to play an important role in many biological processes such as development, healing and regeneration.Through our transcriptome data, we identified and quantified the expression levels of HDAC and histone acetyltransferase (HAT) enzymes during whole body regeneration (WBR). To determine if HDAC activity is required for WBR, we inhibited its action using valproic acid (VPA) and Trichostatin A (TSA). HDAC inhibition prevented the final morphological changes normally associated with WBR and resulted in aberrant gene expression. B. leachii genes including Slit2, TGF-□, Piwi and Fzd4 all showed altered gene expression upon HDAC inhibition in comparison to the control samples. Additionally, atypical expression of Bl_Piwi was found in immunocytes upon HDAC inhibition.Together, these results show that HDAC function, specifically HDAC I/IIa class enzymes, are vital for B. leachii to undergo WBR successfully.
Strong diffusional coupling between spines and dendrites promotes long-term potentiation of Schaffer collateral synapses
Authors: Yin Shuting , Schulze Christian , Oertner Thomas G. 
Published: October 2018

AbstractDendritic spines on CA1 pyramidal cells are highly variable in size and shape. For some spine synapses, long and narrow spine necks provide strong diffusional and electrical isolation from the main dendrite, and it has been speculated that synapses on well isolated spines could be more plastic than synapses on spines with low resistance necks. Here we test this hypothesis by first measuring the diffusional resistance of spine necks, then pairing two-photon glutamate uncaging with bursts of back-propagating action potentials. Paired stimulation induced significant (155%) long-term potentiation (LTP) of synapses on weakly isolated spines, but no net functional change of synapses on highly isolated spines. No correlation was found between spine head volume and functional plasticity of the synapses. We conclude that contrary to our expectations, diffusional isolation makes potentiation of synapses more difficult. Our results support the concept that delivery of plasticity-related proteins from the dendrite into the spine is a limiting factor for LTP.
Heterotypic inter-GPCR ß-arrestin coupling regulates lymphatic endothelial junctional architecture in murine lymph nodes
Authors: Hisano Yu , Kono Mari , Engelbrecht Eric , Kawakami Koki , Yanagida Keisuke , Cartier Andreane , Galvani Sylvain , Kuo Andrew , Ono Yuki , Ishida Satoru , Aoki Junken , Proia Richard L. , Inoue Asuka , Hla Timothy 
Published: October 2018

AbstractLysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) activate G protein-coupled receptors (GPCRs) to regulate key pathobiological processes. Here we report a novel lipid mediator GPCR cross-talk mechanism that modulates lymphatic endothelial junctional architecture in lymph nodes. LPAR1 was identified as an inducer of S1PR1/ ß-arrestin coupling from a genome-wide CRISPR/ Cas9 transcriptional activation screen. LPAR1 activation induced S1PR1 ß-arrestin recruitment while suppressing Gαi protein signaling. Lymphatic endothelial cells from cortical and medullary sinuses of lymph nodes which express LPAR1 and S1PR1, exhibit porous junctional architecture and constitutive S1PR1 coupling to ß-arrestin which was suppressed by the LPAR1 antagonist AM095. In endothelial cells, LPAR1-activation increased trans-endothelial permeability and junctional remodeling from zipper-like structures to puncta of adhesion plaques that terminate at actin-rich stress fibers with abundant intercellular gaps. Cross-talk between LPA and S1P receptors regulates complex junctional architecture of lymphatic sinus endothelial cells, a site of high lymphocyte traffic and lymph flow.
Innovative exploration of safe in-flightcrew escape options
Authors: Karunakaran Sreedhar 
Published: October 2018

Purpose
The purpose of this paper is to explore various in-flight crew escape options of a prototype transport aircraft and finalize the option offering safest crew egress for different combinations of contingencies and flight conditions.

Design/methodology/approach
Various egress options were explored through simulation in a computational fluid dynamics (CFD) software using aircraft 3D CAD model and scalable digital mannequins. For this, certain important contingencies which best describe the extreme aircraft behaviour were identified. Crew escape options, which have least external interference in expected egress trajectory, were selected. Several test simulations representing each feasible combination of contingency, escape option and flight condition were simulated. The option which offers safe crew escape in each test case is deemed to be the safest egress option for the test aircraft.

Findings
Among five options explored, crew escape through forward ventral hatch provided the safest crew escape for all test cases. The selected option was validated for robustness with additional test cases modelling different anthropometric characteristics of 5th and 50th percentile pilot populations with different postures.

Originality/value
In-flight validation of safe crew escape option is infeasible by actual trial. Exploration of safe crew options for required number of test cases by any analytical method or by wind tunnels tests is tedious, time consuming and extremely expensive. On the other hand, exploration of safest crew option by CFD, besides being first of its kind, provides convenient option to configure, test and validate different test cases with unmatched benefits in time, cost and simplicity.
Economic sustainability of green buildings: a comparative analysis of green vs non-green
Authors: Weerasinghe Achini Shanika , Ramachandra Thanuja 
Published: October 2018

Purpose
In Sri Lanka, a limited number of buildings have been certified for incorporation of green features and the reasons are attributed to green building investors who continue to perceive that green buildings are expensive. Further, the green building investors fail to appreciate the subsequent benefits received by those buildings during the operational phase. Therefore, the purpose of this paper is to compare the life cycle cost (LCC) of green certified industrial manufacturing buildings with a similar form of the conventional buildings to establish the economic sustainability of green buildings.

Design/methodology/approach
The study involved a comparative case study analysis of two green buildings and a similar natured conventional building. The data required to perform the LCC analysis were extracted through documentary analysis.

Findings
The comparative analysis shows that the construction cost of a green industrial manufacturing building is 37 per cent higher than that of a similar natured conventional building while operation, maintenance and the end life cost of green buildings result in 28, 22 and 11 per cent savings, respectively. This results in an overall cost saving of 21 per cent in green buildings.

Originality/value
The current study provides an assessment of the total LCC of green industrial manufacturing buildings. In Sri Lanka, green industrial manufacturing buildings offer LCC saving of 21 per cent over its lifetime compared to similar natured conventional buildings. Thus, comparative analyses would enable green investors to make informed decisions before commissioning their investment in green facilities and thereby promote sustainable construction in Sri Lanka.
What does a start-up need to grow? An empirical approach for Italian innovative start-ups
Authors: Innocenti Niccolò , Zampi Vincenzo 
Published: October 2018

PurposeThe purpose of this paper is to capture the role of internal and external characteristics in favouring the growth of innovative start-ups at an early stage of their life.Design/methodology/approachThe empirical approach of this paper is based on an econometric analysis applied to all Italian innovative start-ups with four and five years of life. Growth is analysed after four and five years from the constitution, depending on internal investments in research and development (R&D), in tangible assets and on characteristics external to the firm (110 Italian provinces) related to industrial variety, specialisation, public investments in R&D, etc.FindingsThe results achieved in this study reveal the importance of internal R&D investment even though there is missing evidence on the relevance of general and government specific R&D investment in the area. Other interesting results concern the importance of the firm’s involvement in the technological specialisation of the area and the need for general variety in technological diversification in the area to favour the growth of start-ups.Practical implicationsThe results imply that entrepreneurs should evaluate carefully their strategic choices in terms of the location of the start-up and the investment in R&D as these could be important factors for the firm’s growth.Originality/valueThis paper is an original attempt to measure the importance of both internal and external characteristics for the growth of start-ups. Moreover, the analysis covers the overall population of a new interesting category of firm, the innovative start-up.
Renewable energy investments with storage: a risk-return analysis
Authors: Krömer Sarah , Gatzert Nadine 
Published: October 2018

Purpose
The purpose of this paper is to study investments in renewable energy projects which are jointly operated with an energy storage system, with particular focus on risk-return characteristics from the perspective of private and institutional investors, taking into account resource risk, energy price risk, inflation risk and policy risk.

Design/methodology/approach
To this end, this paper presents a stochastic discounted cash flow model which is then applied to a wind farm with a pumped hydro storage system.

Findings
The results show that energy storage systems have the potential to increase the expected present value of future investment cash flows and to hedge (downside) risk. However, to realize this potential, storage systems have to be cost-effective in terms of fixed operation, maintenance, staffing and insurance costs. Also, several key factors are identified which have a considerable influence on the performance of the operation strategy.

Originality/value
The paper contributes to the literature by conducting an analysis of (downside) risk and return of renewable energy investments with a storage system taking into account stochastic policy, resource, inflation and energy price risk.
Misty consensus, messy dissensus: paradoxes of the Brazilian innovation policies
Authors: Cavalcante Luiz Ricardo 
Published: October 2018

PurposeThe purpose of this paper is to show that the wide acknowledgement of the association between innovation and economic and social development and of the importance of innovation policies has formed a kind of “misty consensus” hardly contested in Brazil. However, the innovation policies adopted in the country lack an institutional framework to support their implementation, marking what is called in this paper a “messy dissensus”.Design/methodology/approachIt is argued that the reasons why the science, technology and innovation (ST&I) policies have failed to contribute more effectively increasing Brazilian technological efforts have less to do with the policies themselves and more to do with their detachment from the institutional framework used to implement them.FindingsIt is shown that this institutional framework: (i) is barely adherent to the perception of the systemic nature of the innovation process; (ii) does not create enough incentives for bureaucrats in public institutions to allocate resources in the industrial sector; (iii) encourages the pulverization of resources and the consequent loss of focus, which may reduce the efficiency of the adopted policies; (iv) encourages the replication of models and priorities usually adopted in contexts that fail to match the Brazilian reality.Originality/valueIn this paper, the focus is on the obstacles that undermine the potential of ST&I policies to contribute more effectively to the improvement of the Brazilian innovation indicators. It is argued that these obstacles have less to do with the innovation policies themselves and more to do with their detachment from the institutional framework used to implement them. This institutional framework includes not only the formal and legal rules but also informal social norms that govern individual behavior and structure social interactions.
How stage theorizing can improve recommendations against phishing attacks
Authors: Tambe Ebot Alain 
Published: October 2018

PurposePhishing remains a major cybersecurity problem. Mainly adopting variance approaches, researchers have suggested several recommendations to help users avoid being victimized in phishing attacks. However, the evidence suggests that anti-phishing recommendations are not very effective. The purpose of this paper is threefold: first, to analyze why the existing anti-phishing recommendations may not be very effective; second, to propose stage theorizing as an additional approach for studying phishing that can contribute toward more effective recommendations; and third, to demonstrate using a stage theory, how IS researchers can utilize the concept of stages in phishing research.Design/methodology/approachThe study draws on findings from previous empirical phishing research to assess whether the reasons why people are victimized in phishing attacks can be categorized into stages. The criteria for stages of the Transtheoretical Model (TTM) are used as an example.FindingsAnalysis indicates support for the existence of stages of phishing victims. The criteria for stages of the TTM were applied to the reasons that subjects in previous studies gave for clicking on phishing links and to the anti-phishing recommendations proposed in previous studies. There was overall support for four of the five criteria of the TTM. The results from the current study indicate that a targeted approach is a better approach to proposing anti-phishing recommendations.Practical implicationsThe analysis identified the stages of phishing victims and the processes of change for each stage. It is suggested that recommendations against phishing should target individuals based on their resident stages. Moreover, the processes of change should be applied to the correct stage for the recommendations to be effective.Originality/valueFrom a phishing perspective, there is a lack of research based on stage theorizing. The current study presents stage theorizing as an additional approach to the existing approaches and demonstrates how a stage theory can be used to make more effective recommendations against phishing. The study has thrown light on the benefits of stage theorizing and how its approach to targeted recommendations can be useful in IS security research.
A third theory: inventive negotiation
Authors: Graham John L. 
Published: October 2018

PurposeThis paper aims to offer a new theory of “inventive negotiation” as a useful alternative to the outdated thinking of the past century.Design/methodology/approachThe literature is reviewed, and a series of stories is used to bolster a new understanding.FindingsThe paper is a critique of the theory of integrative bargaining, arguing that it often limits the creative processes that produce long-term relationships with customers. This paper introduces a third theory of negotiation, something the author calls inventive negotiation.Originality/valueThe primary lesson of negotiation courses in American business and law schools suggests a narrow focus on reaching agreements while paying little attention to implementation and the paramount importance of maintaining ongoing commercial relationships. This paper introduces a third theory of negotiation, something the authors call inventive negotiation. It places emphasis on long-term, trusting commercial relationships as the key outcome of negotiation. The theory also posits negotiation as a creative process wherein innovations processes can play a central role. For example, both group diversity and facilitators can aid in producing creative agreements along the way toward mutually profitable business relationships.
Building a bibliographic hierarchy for manga through the aggregation of institutional and hobbyist descriptions
Authors: Kiryakos Senan , Sugimoto Shigeo 
Published: October 2018

Purpose
Multiple studies have illustrated that the needs of various users seeking descriptive bibliographic data for pop culture resources (e.g. manga, anime, video games) have not been properly met by cultural heritage institutions and traditional models. With a focus on manga as the central resource, the purpose of this paper is to address these issues to better meet user needs.

Design/methodology/approach
Based on an analysis of existing bibliographic metadata, this paper proposes a unique bibliographic hierarchy for manga that is also extendable to other pop culture sources. To better meet user requirements of descriptive data, an aggregation-based approach relying on the Object Reuse and Exchange-Open Archives Initiative (OAI-ORE) model utilized existing, fan-created data on the web.

Findings
The proposed hierarchy is better able to portray multiple entities of manga as they exist across data providers compared to existing models, while the utilization of OAI-ORE-based aggregation to build and provide bibliographic metadata for said hierarchy resulted in levels of description that more adequately meet user demands.

Originality/value
Though studies have proposed alternative models for resources like games or comics, manga has remained unexamined. As manga is a major component of many popular multimedia franchises, a focus here with the intention while building the model to support other resource types provides a foundation for future work seeking to incorporate these resources.
Foreign direct investment and institutional quality: empirical evidence from South America
Authors: Owusu-Nantwi Victor 
Published: October 2018

Purpose
The purpose of this paper is to investigate the effect of institutional quality on foreign direct investment (FDI) flows in South America.

Design/methodology/approach
The study uses two-stage least squares (2SLS) and fixed effect ordinary least squares regression analyses to examine the relationship between institutional quality and FDI in South America.

Findings
The study finds a significant positive relationship between institutional quality index and FDI. This implies that improvements in the institutional quality relate to increases in the flow of FDI to South America. Domestic capital, GDP per capita growth, and trade positively relate to FDI. However, the coefficient of trade is not significant. This implies that increases in these variables relate to increases in FDI flows to South America.

Practical implications
The study recommends that quality of institutions matter to the flow of FDI and therefore, efficient institutional reforms should be a priority for policymakers as this creates a conducive investment environment to attract FDI in South America. Further, policies that are focused on promoting competition, open market, and effective non-corrupt public institution as well as open and transparent legal and regulatory regimes, and effective delivery of government services should be the priority of policymakers in South America (Mishra and Daly, 2007).

Originality/value
The study uses a single measure of institutional quality based on a broad set of institutional indicators. This broad measure of institutional quality differs from the available studies that mainly focused on single aspects of institutional quality, that is, either corruption, governance, or political risk.
Can early initiation to breastfeeding prevent stunting in 6–59 months old children?
Authors: Muldiasman Muldiasman , Kusharisupeni Kusharisupeni , Laksminingsih Endang , Besral Besral 
Published: October 2018

Purpose
The prevalence of stunting in children under five years old is high (37.9 percent). The health advantage of breast milk as a prevention is recognized. The purpose of this paper is to examine the relationship of early initiation to breastfeeding, wherein a child is breastfed within an hour of birth, as a means of preventing stunted growth in 6–59 month old children in Jambi province, Indonesia.

Design/methodology/approach
This paper used data from the 2015 National Nutrition Survey in Jambi province. A total of 2,502 children aged 6–59 months were analyzed by binary logistic regression.

Findings
The results showed that as many as 27.5 percent (95% CI: 25.2–29.9) children aged 6–59 months were stunted and 54.1 percent (95% CI: 51.1–57.1) had not been introduced to breastfeeding soon after birth. The analysis showed that delayed initiation to breastfeeding is a significant factor in stunting amongst 6–59 month old children. (p=0.024; AOR=1.3; 95% CI: 1.0–1.6). Other results of the analysis showed a significant association between water source and birth weight issues as causes for stunting.

Originality/value
Research revealed that delayed initiation into breastfeeding results in a 1.3 times higher risk of stunting. Furthermore, early initiation to breastfeeding reduces the risk of consuming polluted river water that is a health risk and cause of stunting.