bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shed-MEDS: pilot of a patient-centered deprescribing framework reduces medications in hospitalized older adults being transferred to inpatient postacute care
Authors: Petersen Alec W. , Shah Avantika S. , Simmons Sandra F. , Shotwell Matthew S. , Jacobsen J. Mary Lou , Myers Amy P. , Mixon Amanda S. , Bell Susan P. , Kripalani Sunil , Schnelle John F. , Vasilevskis Eduard E. 
Published: June 2018

Background: Polypharmacy is common in hospitalized older adults. Deprescribing interventions are not well described in the acute-care setting. The objective of this study was to describe a hospital-based, patient-centered deprescribing protocol (Shed-MEDS) and report pilot results. Methods: This was a pilot study set in one academic medical center in the United States. Participants consisted of a convenience sample of 40 Medicare-eligible, hospitalized patients with at least five prescribed medications. A deprescribing protocol (Shed-MEDS) was implemented among 20 intervention and 20 usual care control patients during their hospital stay. The primary outcome was the total number of medications deprescribed from hospital enrollment. Deprescribed was defined as medication termination or dose reduction. Enrollment medications reflected all prehospital medications and active in-hospital medications. Baseline characteristics and outcomes were compared between the intervention and usual care groups using simple logistic or linear regression for categorical and continuous measures, respectively. Results: There was no significant difference between groups in mean age, sex or Charlson comorbidity index. The intervention and control groups had a comparable number of medications at enrollment, 25.2 (±6.3) and 23.4 (±3.8), respectively. The number of prehospital medications in each group was 13.3 (±4.6) and 15.3 (±4.6), respectively. The Shed-MEDS protocol compared with usual care significantly increased the mean number of deprescribed medications at hospital discharge and reduced the total medication burden by 11.6 versus 9.1 ( p = 0.032) medications. The deprescribing intervention was associated with a difference of 4.6 [95% confidence interval (CI) 2.5–6.7, p < 0.001] in deprescribed medications and a 0.5 point reduction (95% CI −0.01 to 1.1) in the drug burden index. Conclusions: A hospital-based, patient-centered deprescribing intervention is feasible and may reduce the medication burden in older adults.
Increasing rate of pulmonary embolism diagnosed in hospitalized children in the United States from 2001 to 2014
Authors: Carpenter Shannon L. , Richardson Troy , Hall Matt 
Published: June 2018

Key Points
Rates of pediatric PE in hospitalized patients increased 184% from 2001 to 2014. Mortality as a result of PE in children has decreased over time and is now comparable to that from VTE.
Protecting Adolescents in Low- And Middle-Income Countries from Interpersonal Violence (PRO YOUTH TRIAL): Study Protocol for a Cluster Randomized Controlled Trial of the Strengthening Families Programme 10-14 (“Familias Fuertes”) in Panama
Authors: Mejia Anilena , Emsley Richard , Fichera Eleonora , Maalouf Wadih , Segrott Jeremy , Calam Rachel 
Published: June 2018

Abstract
Background
Interpersonal violence can significantly reduce adolescents’ opportunities for becoming happy and healthy adults. Central America is the most violent region in the world and it is estimated that adolescents are involved in 82% of all homicides in this region. Family skills training programmes have been designed to prevent interpersonal violence in adolescents. Several studies in high-income countries suggest they are effective. However, there are no published trials assessing effectiveness of these programmes in low- and middle-income countries (LMIC). The aim of this study is to test the effectiveness of the Strengthening Families Programme 10–14 (SFP 10–14 or “Familias Fuertes”) in Panama, a LMIC in Central America. An embedded process evaluation will examine the extent to which the intervention is delivered as intended, variation across trial sites, influences on implementation and intervention-context interactions. Cost-effectiveness will also be assessed.

Methods
This is a cluster randomised controlled trial. The 28 townships with the highest homicide rates in Panama will be randomly allocated to implementation of SFP 10–14 alongside services-as-usual or to services-as-usual only. Approximately 30 families will be recruited in each township, a total sample of 840 families. Families will be assessed at baseline, approximately eight weeks after baseline (i.e. post intervention), six months and 12 months after. The primary outcome measure will be the parent reported externalising subscale of the Child Behaviour Checklist at T3 (i.e., which is approximately 12 months after baseline). For the process evaluation, recruitment, attendance, fidelity and receipt will be measured. Qualitative interviews with facilitators, trainers, parents and adolescents will explore barriers/facilitators to implementation and intervention receipt. For the cost-effectiveness analysis, service use information will be gathered from parents and adolescents with a three-month recall period. Costs and consequences associated with implementation of the intervention will be identified.

Discussion
This trial will be the first to evaluate SFP 10–14 in a LMIC. Results have the potential to guide public policies for the prevention of interpersonal violence in Central America and beyond.

Trial registration
ISRCTN Registry, 14023111. Registered on 13 July 2017.
Family therapy and schizophrenia: a brief theoretical overview and a framework for clinical practice
Authors: Burbach Frank R. 
Published: June 2018

SUMMARYFamily or systemic therapy is often contrasted with psychoeducational approaches, but their historical differences have become blurred with the increasing development of integrated family interventions for psychosis. This article describes the theoretical context for the development of integrated family interventions and provides a framework for practice. It presents a collaborative, resource-oriented integrated family intervention for working with families and wider support networks within seven phases: the sharing of information and provision of emotional and practical support; identification of patient, family and wider network resources; encouraging mutual understanding; identification and alteration of unhelpful patterns of interaction; improving stress management, communication and problem-solving skills; coping with symptoms and relapse prevention planning; ending and ensuring that each session is a mini-intervention. It also includes guidelines for family intervention practice, as well as ideas for service development.LEARNING OBJECTIVES•Understand the theoretical developments in the field•Be able to apply the integrated framework to family intervention in practice•Consider different ways of developing family-based servicesDECLARATION OF INTERESTNone.
Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer
Authors: Pietanza M. Catherine , Waqar Saiama N. , Krug Lee M. , Dowlati Afshin , Hann Christine L. , Chiappori Alberto , Owonikoko Taofeek K. , Woo Kaitlin M. , Cardnell Robert J. , Fujimoto Junya , Long Lihong , Diao Lixia , Wang Jing , Bensman Yevgeniva , Hurtado Brenda , de Groot Patricia , Sulman Erik P. , Wistuba Ignacio I. , Chen Alice , Fleisher Martin , Heymach John V. , Kris Mark G. , Rudin Charles M. , Byers Lauren Averett 
Published: June 2018

Purpose Both temozolomide (TMZ) and poly (ADP-ribose) polymerase (PARP) inhibitors are active in small-cell lung cancer (SCLC). This phase II, randomized, double-blind study evaluated whether addition of the PARP inhibitor veliparib to TMZ improves 4-month progression-free survival (PFS). Patients and Methods A total of 104 patients with recurrent SCLC were randomly assigned 1:1 to oral veliparib or placebo 40 mg twice daily, days 1 to 7, and oral TMZ 150 to 200 mg/m2/day, days 1 to 5, of a 28-day cycle until disease progression, unacceptable toxicity, or withdrawal of consent. Response was determined by imaging at weeks 4 and 8, and every 8 weeks thereafter. Improvement in PFS at 4 months was the primary end point. Secondary objectives included overall response rate (ORR), overall survival (OS), and safety and tolerability of veliparib with TMZ. Exploratory objectives included PARP-1 and SLFN11 immunohistochemical expression, MGMT promoter methylation, and circulating tumor cell quantification. Results No significant difference in 4-month PFS was noted between TMZ/veliparib (36%) and TMZ/placebo (27%; P = .19); median OS was also not improved significantly with TMZ/veliparib (8.2 months; 95% CI, 6.4 to 12.2 months; v 7.0 months; 95% CI, 5.3 to 9.5 months; P = .50). However, ORR was significantly higher in patients receiving TMZ/veliparib compared with TMZ/placebo (39% v 14%; P = .016). Grade 3/4 thrombocytopenia and neutropenia more commonly occurred with TMZ/veliparib: 50% versus 9% and 31% versus 7%, respectively. Significantly prolonged PFS (5.7 v 3.6 months; P = .009) and OS (12.2 v 7.5 months; P = .014) were observed in patients with SLFN11-positive tumors treated with TMZ/veliparib. Conclusion Four-month PFS and median OS did not differ between the two arms, whereas a significant improvement in ORR was observed with TMZ/veliparib. SLFN11 expression was associated with improved PFS and OS in patients receiving TMZ/veliparib, suggesting a promising biomarker of PARP-inhibitor sensitivity in SCLC.
Barriers to Cervical Cancer Screening and the Cervical Cancer Care Continuum in Rural Guatemala: A Mixed-Method Analysis
Authors: Austad Kirsten , Chary Anita , Xocop Sandy Mux , Messmer Sarah , King Nora , Carlson Lauren , Rohloff Peter 
Published: June 2018

Purpose Cervical cancer is an important cause of mortality in low- and middle-income countries. Although screening technologies continue to improve, systems of care remain fragmented. It is important to better understand factors that affect use of screening services and loss to follow-up along the care continuum. Methods We conducted a mixed-methods study of a cytology-based screening program in rural Guatemala. A retrospective electronic chart review was performed on data from all patients from 2013 to 2014. We analyzed progression through care and calculated loss–to–follow-up rates. We also analyzed the prior experiences of patients with cervical cancer screening on the basis of self-reported historical data available in the chart review. Structured interviews with a subset of individuals to explore social supports and barriers to screening and engagement in care were conducted at the time of screening. Results The analysis included 515 women (median age, 36 years). Cytologic screening showed concern for neoplastic changes in 0.83%; half resulted in biopsy-proven cervical intraepithelial neoplasia. An additional 9.9% showed severe inflammation. The rate of loss to follow–up was 11.3%. All losses to follow-up occurred for severe inflammation, not for cervical intraepithelial neoplasia. Historical data showed that 73% of the cohort had previously been screened and had high levels of loss to follow-up (57.4%). Qualitative interviews revealed factors that promoted loss to follow-up; these included cost, lack of social supports, transportation, distrust in public facilities, long turn-around times, and failure to return test results or offer follow-up treatments. Conclusions Taken together, these quantitative and qualitative results highlight the need for cervical cancer screening programs in Guatemala to improve uptake of screening services by eligible women and to improve follow-up after a first abnormal screen.
Why do mammals hop? Understanding the ecology, biomechanics and evolution of bipedal hopping
Authors: McGowan Craig P. , Collins Clint E. 
Published: June 2018

ABSTRACT
Bipedal hopping is a specialized mode of locomotion that has arisen independently in at least five groups of mammals. We review the evolutionary origins of these groups, examine three of the most prominent hypotheses for why bipedal hopping may have arisen, and discuss how this unique mode of locomotion influences the behavior and ecology of modern species. While all bipedal hoppers share generally similar body plans, differences in underlying musculoskeletal anatomy influence what performance benefits each group may derive from this mode of locomotion. Based on a review of the literature, we conclude that the most likely reason that bipedal hopping evolved is associated with predator avoidance by relatively small species in forested environments. Yet, the morphological specializations associated with this mode of locomotion have facilitated the secondary acquisition of performance characteristics that enable these species to be highly successful in ecologically demanding environments such as deserts. We refute many long-held misunderstandings about the origins of bipedal hopping and identify potential areas of research that would advance the understanding of this mode of locomotion.
Experimental huts trial of the efficacy of pyrethroids/piperonyl butoxide (PBO) net treatments for controlling multi-resistant populations of Anopheles funestus s.s. in Kpomè, Southern Benin
Authors: Akoton Romaric , Tchigossou Genevieve M. , Djègbè Innocent , Yessoufou Akadiri , Atoyebi Michael Seun , Tossou Eric , Zeukeng Francis , Boko Pelagie , Irving Helen , Adéoti Razack , Riveron Jacob , Wondji Charles S. , Moutairou Kabirou , Djouaka Rousseau 
Published: June 2018

Background:Insecticides resistance inAnophelesmosquitoes limits Long-Lasting Insecticidal Nets (LLIN) used for malaria control in Africa, especially Benin. This study aimed to evaluate the bio-efficacy of current LLINs in an area whereAn. funestuss.l.andAn. gambiaehave developed multi-resistance to insecticides, and to assess in experimental huts the performance of a mixed combination of pyrethroids and piperonyl butoxide (PBO) treated nets on these resistant mosquitoes.Methods:The study was conducted at Kpomè, Southern Benin. The bio-efficacy of LLINs againstAn. funestus and An. gambiaewas assessed using the World Health Organization (WHO) cone and tunnel tests. A released/recapture experiment following WHO procedures was conducted to compare the efficacy of conventional LLINs treated with pyrethroids only and LLINs with combinations of pyrethroids and PBO. Prior to huts trials, we confirmed the level of insecticide and PBO residues in tested nets using high performance liquid chromatography (HPLC).Results:Conventional LLINs (Type 2 and Type 4) have the lowest effect against local multi-resistantAn. funestus s.s. and An. coluzziipopulations from Kpomè. Conversely, when LLINs containing mixtures of pyrethroids and PBO (Type 1 and Type 3) were introduced in trial huts, we recorded a greater effect against the two mosquito populations (P < 0.0001). Tunnel test withAn. funestus s.s.revealed mortalities of over 80% with this new generation of LLINs (Type 1 and Type 3),while conventional LLINs produced 65.53 ± 8.33% mortalities for Type 2 and 71.25 ±7.92% mortalities for Type 4. Similarly, mortalities ranging from 77 to 87% were recorded with the local populations ofAn. coluzzii.Conclusion:This study suggests the reduced efficacy of conventional LLINs (Pyrethroids alone) currently distributed in Benin communities whereAnophelespopulations have developed multi-insecticide resistance. The new generation nets (pyrethroids+PBO) proved to be more effective on multi-resistant populations of mosquitoes.
The Finnish Great Depression of the 1990s: reconciling theory and evidence
Authors: Kuusi Tero 
Published: June 2018

Abstract
This paper reconciles quantitative macroeconomic theory of the Finnish Great Depression and the empirical evidence. The main controversy is that the existing theoretical work assigns a larger role for the collapse of the trade with the Soviet Union than the empirical evidence would suggest. This paper argues that explaining the Finnish crisis warrants a model with involuntary unemployment, and that the collapse resulted mainly from increased financial constraints, not the Soviet trade collapse. While it has been argued and that a large Soviet-trade contribution would result from costly reallocation of resources away from the Soviet sector, and trade-induced income effects that hit the consumption in the domestic sector, this paper finds it hard to reconcile them with the actual evidence. The economic collapse was wide-spread, and the domestic sector collapse reflects decline in investment rather than consumption.
Mercury fractionation in gypsum using temperature desorption and mass spectrometric detection
Authors: Pavlin Majda , Popović Arkadij , Jaćimović Radojko , Horvat Milena 
Published: June 2018

Abstract
A quadrupole mass spectrometer was used to study the thermal release of mercury from wet flue gas desulphurization (WFGD) gypsum using temperature-programmed desorption/decomposition (TPD). The inability in direct detection of low concentrations of mercury halogenides in gypsum by mass spectrometry is discussed in detail. The hydrolysis of HgCl2 vapours under specific experimental conditions in the mass spectrometer was considered theoretically and proved experimentally. The mercury concentration in different gypsum fractions varies from 0.22 mg kg-1 (3.27-148 μm, coarse particles) to 20.6 mg kg-1 (0.41-88.0 μm, fine particles). All samples had a similar, symmetrical, single-peak (peak maximum 253–266°C) in the TPD spectra. In the present study, the use of ‘wet’ methods for preparing mercury compounds is introduced in addition to the mercury standards prepared using the ‘dry’ method, as commonly found in TPD. The study showed that selected metals, such as Fe enriched in gypsum samples, significantly influence the shape and the maximum temperature of the Hg TPD curves and that during the mercury compound preparation and the TPD process, Hg species undergo transformations that prevent the identification of their original identity.
Phytosynthetic Ag doped ZnO nanoparticles: Semiconducting green remediators
Authors: Ahmad Khuram Shahzad , Jaffri Shaan Bibi 
Published: June 2018

AbstractHighly stable semiconducting silver doped zinc oxide nanoparticles have been synthesized via facile, biomimetic and sustainable route, through utilization of Zinc acetate dihydrate (C4H6O4Zn · 2H2O) as host, Silver nitrate (AgNO3) as dopant and phytochemicals of angiospermic medicinal plantPrunus cerasiferaas the reducing agents. Synthesis of Ag doped ZnO nanoparticles was done in a one pot synthetic mode by varying the amount of dopant from 0.2 – 2.0%. Synthesized photocatalyst nanoparticles were analyzed via UV-vis, FTIR, XRD and SEM. Commendable alleviation in the direct band gap i.e. 2.81 eV was achieved as a result of doping. Silver doped zinc oxide nanoparticles size ranged between 72.11 – 100 nm with rough surface morphology and higher polydispersity degree. The XRD patterns revealed the hexagonal wurtzite geometry of crystals with an average crystallite size of 2.99 nm. Persistent organic dyes Methyl Orange, Safranin O and Rhodamine B were sustainably photodegraded in direct solar irradiance with remarkable degradation percentages up to 81.76, 74.11 and 85.52% in limited time with pseudo first order reaction kinetics (R2=0.99, 0.99 and 0.97). Furthermore, efficient inhibition against nine microbes of biomedical and agriculturally significance was achieved. Synthesized nanoparticles are potential green remediators of polluted water and perilous pathogens.
Thermal Sensations During a Partial-Body Cryostimulation Exposure in Elite Basketball Players
Authors: Bouzigon Romain , Ravier Gilles , Dugue Benoit , Grappe Frederic 
Published: June 2018

Abstract
Partial-body cryostimulation is used to improve recovery after exercise, especially during competitions or heavy training; however, a limited number of studies have been conducted with international-level athletes in situ during competitions. This study was undertaken to assess the thermal sensation ratings during 3 min of cold exposure (at –130°C) in 24 international-level athletes during the European Basketball Championship. The mean thermal sensation score, measured using a perceptive scale, increased significantly (p < 0.05) during partial-body cryostimulation exposure in athletes from 3.0 ± 1.7 at 30 s to 5.7 ± 2.3 at 3 min (maximal observed value = 10.0). The mean value of 5.7 is considered a “cold” sensation on the scale (ranging from 0 = neutral sensation to 10 = very cold). However, we observed a large inter-individual variation in the perceived thermal sensations. The body mass index was significantly and negatively correlated with the thermal sensation value after 2 min 30 s and 3 min of exposure in females (r = –0.61, n = 13, p < 0.05; r = –0.56, n = 13, p = 0.054, respectively). Three participants reported high perceived thermal sensation after 30 s of exposure and their cold-induced discomfort worsened as the exposure continued. In conclusion, a 3-min exposure is globally well tolerated by athletes and can be used during a heavy competition period and/or during a training period. However, special attention should be given to female athletes with a low body mass index as they seem to be much more sensitive to cold.
Novel Solutions in Modeling of Anaerobic Digestion Process - Two-Phase AD Models Development and Comparison
Authors: Postawa Karol 
Published: June 2018

Abstract
This work focuses on Two Phase Anaerobic Digestion – a novel approach to split reactions’ chain in two separated tanks, each with specialized microbe community to achieve the best possible efficiency for each part of conversion. More specifically, the article tackle the topic of evaluation the possibility to adapt a mathematical model, previously dedicated for Autogenerative High Pressure Digestion (AHPD), to make use of it in simulation of Temperature Phased Anaerobic Digestion (TPAD) process. A comprehensive study of available solutions for biogas production simulation in conventional and TPAD configuration is additionally performed. Basing on its results, a reference model from literature, for comparison purpose is selected. Revisions and modifications, necessary to adjust previously developed model, to TPAD process, are described. Also, additional improvements like redesigned pH calculating algorithm is presented. Finally, the comparison between model predictions, a reference model and pilot-scale data is carried out. The results show that our current model needs further optimization, however even at this stage it provides acceptable results in short-range simulations (not longer than 42 days). Further works should focus on process stability improvement, especially in the thermophilic stage of biogas production. There's an opportunity for innovation as the research shows that requirement of accurate, large-scale optimized TPAD process model, is still not fulfilled.