bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise-Induced Platelet Activation in Myocardial Infarction Survivors with Normal Coronary Arteriogram
Authors: Douste-Blazy Ph , Sié P , Boneu B , Marco J , Eche N , Bernadet P 
Published: July 2018

SummaryPlatelet activation may participate in the pathophysiology of myocardial infarction occurring in patients with normal coronary arteriogram. We investigated this possibility in a series of 9 such patients (group A) during a standardized bicycle excercise test as myocardial infarction had occurred in all of them during or soon after strong physical exercise. Twelve patients with effort-induced angina and coronary atherosclerosis (group B) and eleven healthy subjects (group C) served as test groups. Peripheral venous blood was collected by separate venipuncture before, at peak exercise and during recovery. As a sensitive index of activation, the shape of the circulating platelets was examined with a phase contrast microscope after instantaneous fixation of the whole blood. The percentage of non strictly disc-shaped platelets with one or more thin pseudopods was determined. Simultaneously, the plasma levels of platelet factor 4 (PF4) and of beta-thromboglobulin (β-TG) were measured. At rest, there was no significant difference in the platelet morphology nor in the plasma levels of platelet specific proteins between the three groups. During exercise, a significant change in platelet shape occurred in group A and B patients and not in the healthy subjects. This platelet activation was not related to myocardial ischemia since it occurred to a similar extent in group B patients who developed electrocardiographic changes and in group A patients who did not. There was no detectable release of platelet proteins during exercise in any group.
Urinary Excretion Rate of Antithrombin III Related Antigen in Cerebral Stroke
Authors: Matsuo T , Shinomiya K , Okuno S , Matsuo C , Matsuo O 
Published: July 2018

SummaryThe urinary excretion rate of antithrombin III related antigen (AT III RA) was examined in cerebral stroke. The excretion rate of AT III RA in cerebral hemorrhage (CH) was 12.33 ± 1.61 × 10-4 ml/min. The patients with CH were further classified into two groups: in group CH-I, whose consciousness state was stupor or further deteriorated including coma on admission, the excretion rate of AT III RA was 18.08 ± 2.50 × 10-4 ml/min. In group CH-II, whose consciousness state was clear on admission, the excretion rate of AT III RA was significantly lower than that in CH-I (6.20 ± 1.56 × 10-4 ml/min). The excretion rate in cerebral thrombosis (CT) was 1.96 ± 0.25 × 10-4 ml/min, which was significantly lower than that in CH. The excretion rate of AT III RA in both CH and CT was significantly higher than that in the healthy control group (0.29 ± 0.04 × 10-4 ml/min). Thus, AT III may change dynamically in cerebral stroke.
Effect of Anti-Thrombospondin Antibodies on the Hemagglutination Activities of the Endogenous Platelet Lectin and Thrombospondin
Authors: Gartner T Kent , Doyle Mary Jean , Mosher Deane F 
Published: July 2018

SummaryThe proposal that thrombospondin is the endogenous platelet lectin was evaluated using antisera and monoclonal antibodies to thrombospondin. The platelet-bound hemagglutinin activity of human platelets stimulated with A23187 was inhibited by rabbit anti-thrombospondin sera and by a monoclonal anti-thrombospondin IgG. A second monoclonal IgG did not inhibit platelet- bound agglutinin activity. Preparations of purified platelet thrombospondin differed in their hemagglutination activities. The hemagglutination activity of an active preparation of thrombospondin was inhibited by the monoclonal antibody that inhibited platelet-bound lectin activity. The hemagglutination activity of an almost inactive preparation of thrombospondin was enhanced by the anti-thrombospondin monoclonal antibody that did not block platelet-bound lectin activity. The results demonstrate that expression of the platelet-bound form of the endogenous lectin is thrombospondin-dependent and suggest that thrombospondin must become part of a larger complex, either by binding to the platelet surface or by becoming aggregated in solution, before hemagglutination activity can be expressed.
Urine Beta-Thromboglobulin Concentration or Beta-Thromboglobulin/Creatinine Ratio in Single Voided Urine Samples Cannot Be Reliably Used to Estimate Quantitative Beta-Thromboglobulin Excretion
Authors: Musumeci V , Rosa S , Caruso A , Zappacosta B , Tutinelli F , Zuppi C 
Published: July 2018

SummaryDifferent procedures are currently used in the urine beta-thromboglobulin (BTG) assay. We investigated the reliability of limited urine collections and of different expressions of urine BTG results (concentration, urine BTG/creatinine ratio) for the measurement of hourly or daily BTG excretion rates. BTG was measured by a sensitive RIA method in various urine collections of normal subjects (n.80) and patients (n.120) with miscellaneous diseases where an enhanced in-vivo platelet activation could be expected. The BTG concentration in a 6-hour urine collection appeared to change in relation to the urine flow rate (r = -0.53 in normals, r = 0.27 in patients, p <0.01) and urine osmolality (r = 0.46 in normals, r = 0.31 in patients, p <0.01). In both normals and patients not a very good correlation was observed between the urine BTG/creatinine ratio and the BTG excretion rate (r = 0.54 and r = 0.48; p <0.001, respectively). Variable coefficients of correlation (r = 0.83-0.34) were observed between the BTG excretion rate of single voidings of the morning, afternoon-evening and night and the daily BTG excretion both in normals and patients. Reliable measurements of the BTG in urine should be expressed as the hourly excretion rate in a given period of the day for limited urine collections or as the daily excretion for 24-hour urine collections.
Hemostatic Parameters in Newborn - II. Sequential Study During the First Four Weeks of Life
Authors: Kolindewala J K , Dube B , Bhargava V , Dube R K , Kota V L N , Das B K 
Published: July 2018

SummaryA sequential study of kaolin cephalin clotting time (KCCT), prothrombin time (PT), thrombin time (TT), plasma fibrinogen and serum FDP was conducted during the first four weeks of life on term and preterm babies. A “physiological dip” of PT and TT was noted inappropriate for gestational age (AGA) babies both term and preterm; in case of KCCT, the dip was significant in term AGA babies only. At the end of four weeks, PT and TT had moderately improved in term babies but showed little improvement in preterm ones; KCCT reached almost an adult value in all babies except in preterm AGA and term LGA (large for gestational age) ones. Plasma fibrinogen showed no “physiological dip” and reached adult level in two to four weeks. Serum FDP levels were appreciably raised in preterm AGA babies only at birth and there too normalised by 72 h.
The Fast-Acting Inhibitor of Tissue-Type Plasminogen Activator in Plasma Is also the Primary Plasma Inhibitor of Urokinase
Authors: Kruithof Egbert K.O , Tran-Thang Chiên , Bachmann Fedor 
Published: July 2018

SummaryWe have compared the ability of a plasminogen activator inhibitor (PA-inhibitor) in human plasma, to form complexes with radioiodinated tissue-type plasminogen activator (t-PA) and high molecular weight urokinase (HMr-UK). Addition of 125I-t-PA (final concentration 10 IU/ml) or of 125I-HMr-UK (2 IU/ml) to a plasma containing 33 U/ml of PA-inhibitor resulted in the rapid formation of a 110,000 Mr complex of 125I-t-PA or a 95,000 Mr complex of 125I-HMr-UK with PA-inhibitor. Upon prolonged incubation of the plasma with 125I-HMr-UK a secondary complex of a Mr of 88,000 was observed, which probably derives from limited degradation of the 95,000 complex. Preincubation of the plasma with unlabelled t-PA, HMr-UK or LMr-UK at higher concentrations prevented the subsequent formation of complexes between radiolabelled PAs and the PA-inhibitor. These results thus demonstrate that t-PA and UK form complexes with the same PA-inhibitor. The rate of complex formation of 125I-t-PA or of 125I-HMr-UK with the plasma PA-inhibitor was similar (second order rate constant of association with PA-inhibitor in the order of 107 M−1s−1).
A Sensitive Assay, Specific for Endothelial Cell Type Plasminogen Activator Inhibitor in Blood Plasma
Authors: Sprengers E D 
Published: July 2018

SummaryA polyclonal antibody raised against plasminogen activator (PA-)inhibitor from endothelial cells fully precipitates the PA-inhibitor in endothelial cell conditioned medium but only a part of the PA-inhibitory activity in blood plasma. This indicates that the PA-inhibitory activity in blood plasma is not due to a single inhibitory component. Performing the assay for PA-inhibitory activity in plasma both in the presence and absence of saturating concentrations of anti-endothelial cell PA-inhibitor antibodies, allows the determination of endothelial cell type PA-inhibitor in plasma. The assay gives a linear dose-response curve of amount of plasma added versus t-PA neutralised.Values for endothelial cell type PA-inhibitor in plasma of a group of 20 healthy individuals are in the range of 0.0-16.8 IU/ml and are not normally distributed (median value 3.0 IU/ml).This method also reveals a second, so far unidentified, PA-inhibitory component in human plasma.
Isolation and Preliminary Characterisation of Active B-Chain of Recombinant Tissue-Type Plasminogen Activator
Authors: Dodd I , Fears R , Robinson J H 
Published: July 2018

SummaryPurified 2-chain recombinant tissue-type plasminogen activator (t-PA) was reduced under mild conditions - 10 mM dithiothreitol/ 5° C/1.5 h - and the two chains were separated by chromatography on lysine Sepharose. The t-PA B chain was fully active as determined by its activity towards the chromogenic substrate S-2288 (H-D-ile-pro-arg p-nitroanilide). Analysis by sodium dodecyl sulphate polyacrylamide gel electrophoresis under reducing or non-reducing conditions revealed a single polypeptide at Mr = 35,000 or 29,000 respectively. In addition, under non-reducing conditions a fibrinolytic band at apparent Mr = 29,000 was present after fibrin zymography. The N-terminal sequence was confirmed as ile-lys-gly. The t-PA B chain had a specific amidolytic activity, using S-2288, of 170,000 to 210,000 SU/mg protein. (This compares to a specific activity of the native 2-chain t-PA of 170,000 SU/mg). It resembles urokinase-type plasminogen activator in its inability to be stimulated by fibrin and its dose response on human fibrin plates. However, t-PA B-chain was stimulated to almost the same extent as t-PA by poly-D-lysine. The isoelectric points, at pH 5.6 and 5.7, fall outside the range generally quoted for t-PA preparations (pH 7.8-8.8).
Inertial Sensors are a Valid Tool to Detect and Consistently Quantify Jumping
Authors: Spangler Rhys , Rantalainen Timo , Gastin Paul , Wundersitz Daniel 
Published: July 2018

AbstractConsidering the large and repetitive loads associated with jumping in team sports, automatic detection and quantification of jumping may show promise in reducing injury risks. The aim of this study was to validate commercially available inertial-movement analysis software to detect and quantify jumping in team sports. In addition, the test-retest reliability of the software to quantify jumping was assessed. Seventy-six healthy male participants completed a team sport circuit six times containing seven common movements (including three countermovement and two single-leg jumps) whilst wearing an inertial sensor (Catapult Sports, Australia). Jump detection accuracy was assessed by comparing the known number of jumps to the number recorded by the inertial movement analysis software. A further 27 participants separately performed countermovement and single-leg jumps at 33%, 66% and 100% of maximal jump height over two sessions. Jump height quantification accuracy was assessed by comparing criterion three-dimensional motion analysis-derived heights to that recorded by the inertial movement analysis software. Test-retest reliability was assessed by comparing recorded jump heights between both testing sessions. Catapult’s inertial movement analysis software displayed excellent jump detection accuracy (96.9%) and test-retest jump height quantification reliability (ICC: 0.86 [countermovement jump], 0.88 [single-leg jump]). However, significant mean bias (–2.74 cm [95% LoA –10.44 – 4.96]) was observed for jump height quantification. Overall, Catapult’s inertial movement analysis software appears to be a suitable method of automatically detecting jumping in team sports, and although reliable, caution is advised when using the IMA software to quantify jump height.
Rates of cavity filling by liquids
Authors: Seo Dongjin , Schrader Alex M. , Chen Szu-Ying , Kaufman Yair , Cristiani Thomas R. , Page Steven H. , Koenig Peter H. , Gizaw Yonas , Lee Dong Woog , Israelachvili Jacob N. 
Published: July 2018

Significance
In engineering and natural phenomena, various fluids contact rough/textured surfaces, e.g., wicking, facial creams, corrosion-preventive paints, and rain on plant leaves. Liquids on rough surfaces, especially those with cavities, pits, or pores, may or may not transit from the unfilled or partially filled (wetted) state to the fully filled (fully wetted) state. Either one of these states may be desired for a given application (compare superhydrophobicity) or even survival (compare oil-soaked feathers). In this article, we present five variables that control the wetting behavior (cavity filling) of water on intrinsically hydrophilic surfaces with micrometer-sized cavities. Our experimental results and theoretical analysis provide criteria for maintaining either the partially filled state, or quickly transiting to the fully filled state, and insights into other related wetting phenomena.
Prosodic separation of postverbal material in Georgian
Authors: Skopeteas Stavros , Féry Caroline , Asatiani Rusudan 
Published: July 2018

Abstract
A striking property of Georgian intonation is that focused postverbal material is prosodically separated from the core clause. The challenge of the present study is to assess the external validity of this experimental result by means of a corpus study. Corpus data is known to contain immense variability due to uncontrolled factors related to spontaneous speech production, such as segmental effects, intra-speaker variation, etc. The corpus study confirmed that the right edge of the verb is frequently associated with a prosodic boundary that separates the prosodic constituent encompassing the verb and the preverbal material from the postverbal domain. This boundary can be overwritten by information structure, in particular by postfocal dephrasing.
Macrosyntactic corpus annotation
Authors: Caron Bernard 
Published: July 2018

Abstract
This paper argues for a minimal annotation representing in a simple and concise way the interface between information structure and syntax. The article uses the concept of macrosyntax, based on illocutionary units, for a new level of annotation using existing morphosyntactic tiers in Elan. One of the main assets of this system of annotation lies in the notion of piles it uses to represent the oral discursive flow and account for dysfluencies, discontinuities and ellipses. A pilot 15,000 words corpus has been annotated in Elan to run a preliminary study of the information structure of illocutionary components in Zaar, a Chadic language spoken in Nigeria. Their micro- and macro-syntactic properties are represented using Universal Dependencies Grammar.
Focus marking and differential argument marking
Authors: Nikitina Tatiana 
Published: July 2018

Abstract
Wan makes use of a bidirectional case marker that does not attach to either the subject or the object but serves to separate core arguments that would otherwise be adjacent. The use of this optional marker depends on factors that are known to condition alignment splits in other languages (such as pronominality). Bidirectional case marking is but one strategy employed by speakers of Wan to avoid dispreferred combinations of adjacent subjects and objects. It is closely related to the marking of information structure: the same marker is also used to mark focus. The study presents an Optimality-Theoretic account of this relationship and draws parallels between the bidirectional case marking of Wan and systems of optional or pragmatic ergativity.
Information structure in the Neo-Aramaic dialect of Telkepe
Authors: Coghill Eleanor 
Published: July 2018

Abstract
This paper describes the expression of information structure in the North-Eastern Neo-Aramaic dialect of Telkepe, a town in northern Iraq. Based on the author’s fieldwork data, it looks at the various ways in which information structure is given linguistic expression in the dialect, in particular indexing on the verb, differential object flagging, word order, and the position of the nuclear stress. It is then shown that the findings for Telkepe provide supportive evidence for some of the universals of information structure proposed by Gundel (1988).
Information structure in a spoken corpus of Cameroon Pidgin English
Authors: Green Melanie , Ozón Gabriel 
Published: July 2018

Abstract
We explore information structure in a spoken corpus of Cameroon Pidgin English, addressing the broad question of how far the corpus method addresses the needs of research in this area. Focusing on marked pronouns used in focus/topic constructions and the copula/focus marker na, we detail a method for investigating information structure in the corpus. Corpus analysis not only confirms but elaborates an emergent description allowed by the elicitation stage, demonstrating that while elicitation reveals what is possible, corpus analysis reveals what is preferred. However, we conclude that qualitative analysis is still required to identify instances of focus in the absence of marked morphosyntactic features, as well as interpretations governed by context.
Annotation guidelines for Questions under Discussion and information structure
Authors: Riester Arndt , Brunetti Lisa , De Kuthy Kordula 
Published: July 2018

Abstract
We present a detailed manual for a pragmatic, i.e. meaning-based, method for the information-structural analysis of naturally attested data, which is built on the idea that for any assertion contained in a text (or transcript of spoken discourse) there is an implicit Question under Discussion (QUD) that determines which parts of the assertion are focused or backgrounded (and which ones are not at issue, i.e. not part of the assertion at all). We formulate a number of constraints, which allow the analyst/annotator to derive QUDs from the previous or upcoming discourse context, and demonstrate the method using corpus examples (of French, German, and English). Since we avoid making reference to language-specific morphosyntactic or prosodic properties, we claim that our method is also cross-linguistically applicable beyond our example languages.
Mechanical behaviour and microstructure of heat-treated Cu–Ni–Si alloy
Authors: Stavroulakis Paul , Toulfatzis Anagnostis , Vazdirvanidis Athanasios , Pantazopoulos George , Papaefthymiou Spyros 
Published: July 2018

Cu–Ni–Si alloys exhibit a good combination of strength and electrical conductivity and may be a potential candidate for utilisation in electrotechnical applications. In this work, the mechanical behaviour and its relation to the microstructure of a Cu–Ni–Si alloy, subjected to different solution heat treatment cycles, were investigated. Tensile, bend and hardness testing, in addition to Optical and Scanning Electron Microscopy, were employed, as the main analytical techniques, in the context of the present investigation. This paper is part of a Thematic Issue on Copper and its Alloys.
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H
Authors: Yu Genhua , Liao Jiaqun , Wu Junlan , Ding Jun , Zhang Lin 
Published: July 2018

ABSTRACT
Colorectal cancer is one of the most common causes of cancer-related deaths worldwide. Eukaryotic translation initiation factor 3, subunit H (EIF3H) is a subunit of EIF3, which is involved in mRNA recruitment and ribosomal complex disassembly and is known to be a driver of cell proliferation and survival in cancer. To investigate its function in colorectal cancer, the Oncomine database was used to evaluate the expression of EIF3H in human colorectal cancer and normal tissues. Then, we constructed a Lentivirus shorthair EIF3H vector (Lv-shEIF3H) to silence EIF3H expression in the colorectal cancer cell lines HCT116 and SW1116. We observed impaired cell growth and colony formation in these silenced cell lines. In addition, we showed that EIF3H knock-down led to cell apoptosis. In conclusion, EIF3H plays key roles in the apoptosis in colorectal cancer cells, which suggests EIF3H as a potential diagnostic biomarker in colorectal cancer.
SOBIR1 and AGB1 independently contribute to nonhost resistance to Pyricularia oryzae (syn. Magnaporthe oryzae) in Arabidopsis thaliana
Authors: Takahashi Toshiharu , Murano Tomoya , Ishikawa Atsushi 
Published: July 2018

ABSTRACT
Rice blast caused by Pyricularia oryzae (syn. Magnaporthe oryzae) is a disease devastating to rice. We have studied the Arabidopsis-P. oryzae pathosystem as a model system for nonhost resistance (NHR) and found that SOBIR1, but not BAK1, is a positive regulator of NHR to P. oryzae in Arabidopsis. AGB1 is also involved in NHR. However, the genetic interactions between SOBIR1, BAK1, and AGB1 are uncharacterized. In this study, we delineated the genetic interactions between SOBIR1, BAK1, and AGB1 in NHR to P. oryzae in Arabidopsis and found SOBIR1 and AGB1 independently control NHR to P. oryzae in Arabidopsis pen2-1 mutant plants. Furthermore, XLG2, but not TMM, has a positive role in penetration resistance to P. oryzae in Arabidopsis pen2-1 mutant plants. Our study characterized genetic interactions in Arabidopsis NHR.
Abbreviations: PRR: pattern recognition receptor, RLK: receptor-like kinase, RLP: receptor-like protein, BAK1: BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1, BIR1: BAK1-INTERACTING RECEPTOR-LIKE KINASE 1, SOBIR1: SUPPRESSOR OF BIR1-1-1, AGB1: ARABIDOPSIS G PROTEIN ß-SUBUNIT 1, XLG2: EXTRA-LARGE G PROTEIN 2
Periodic Limb Movements During Sleep Are Not Associated With Hypertension in a Clinical Cohort of Korean Adults
Authors: Shin Dae-Seop , Yang Kwang Ik , Kim Doh-Eui , Hwangbo Young , Koo Brian B , Cho Yong Won 
Published: July 2018

Abstract

BACKGROUND
There is growing evidence of increased cardiovascular risk including hypertension in patients with periodic limb movements during sleep (PLMS). In a multiethnic cohort study, the association between prevalent hypertension and PLMS varied according to ethnicity. We evaluated whether PLMS are associated with hypertension in Koreans.

METHODS
We enrolled 1,163 subjects who had polysomnography (PSG) from 2 tertiary hospitals. All subjects completed a sleep questionnaire before the PSG study. Coincidental hypertension was recorded according to past medical history. We analyzed the association between periodic limb movement index (PLMI), periodic limb movement associated with arousal index (PLMAI), and coincidental hypertension. Covariates were age, sex, body mass index (BMI), restless legs syndrome, apnea−hypopnea index (AHI), arousal index, and average oxygen saturation.

RESULTS
A total of 304 subjects (26.1%) had hypertension. The proportion of subjects with hypertension in the PLMI ≥ 15 category was higher than that in the PLMI &lt; 15 category (32.4% vs. 25.0%; P = 0.04). The proportion of subjects with hypertension in the PLMAI ≥ 1 category was 32.6%, which was higher than that in the PLMAI &lt; 1 category (24.6%; P = 0.02). In a multivariate regression model, neither PLMI (odds ratio [OR], 1.12; 95% confidence interval [CI] 0.75–1.68) nor PLMAI (OR, 1.21; 95% CI 0.83–1.76) were associated with hypertension. Statistical significance was found between coincidental hypertension and the following variables: age, smoking history, BMI, and AHI.

CONCLUSIONS
In a retrospective hospital-based study, there was no association between coincidental hypertension and PLMI/PLMAI in Koreans.