bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREDICTION THE MANIFESTATION OF PYELONEPHRITIS IN PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: Zub L.O. , Kulachek V.T. 
Published: June 2018

Renal damage in patients with rheumatoid arthritis (RA) is the most frequent and serious among other systemic manifestations and holds a special place in connection with a significant impact on prognosis and approaches to therapy.
Today we know that one of the main possible factors of occurrence and development of RA are external trigger factors, among which the most important factor are infectious, and its pathogenic effect on the body can be done in different ways. Based on the latest scientific evidence on the importance of infectious trigger factors in the manifestation of RA, chronic pyelonephritis among these triggers is one of the leaders. Great interest is also the probability of pyelonephritis manifestation while presence of RA.
The aim: to identify predictors ofpyelonephritis manifestation in patients with rheumatoid arthritis.
Materials and methods. The authors examined 31 patients with RA with presence of chronic pyelonephritis (CP), 31 patients with RA without presence of CP and 20 healthy individuals. Was used clustering and classification methods of Data Mining on indicators of lipid peroxidation of blood and urine, р2–microglobulin blood and urine, immune factors, that defined progressive CKD on the results of our previous studies (IL–1p,IL–10, TGF–р).
Results. Found that patients with diagnosed RA only, mainly are included in the cluster «1» (18patients). Some of them (3 persons) classified as belonging to the cluster «2». Thus, these individuals should have two signs of disease, RA and CP, despite the fact that they have only diagnosed RA. It means that these patients are at risk of developing CP. This analysis gives grounds to consider that RA may be signs of a factor that causes manifestation of CP.
It is proved that the main factor that characterizes the individuals belonging to the cluster of healthy is 2– microglobulin in the urine with the same threshold value, but factor in determining membership of a type of disease is a factor MDA of urine.
Conclusion. The main predictors of pyelonephritis manifestation in patients with rheumatoid arthritis were 2– microglobulin and MDA in urine and TGF– 1 in blood. A new method of diagnosing ofprognostic factors of CP manifestation in patients with RA which is based on cluster and classification analysis makes it possible to establish the interrelation between a diagnosis of RA and caused by it manifestation of CP.
РARTICULAR QUALITIES OF THE RENAL OSMOREGULATORY FUNCTION IN PATIENTS WITH TYPE 2 DIABETES
Authors: Kuznetsova E.S. , Kuznetsova A.S. , Shuhtin V.V. , Gozhenko A.I. 
Published: June 2018

The aim of the study was to examine the osmoregulatory state of renal function in patients with type 2 diabetes in a water - salt load with 0,5% NaCl in the amount of 0.5% of body weight.
Materials and methods. The study involved 56patients with insulin - dependent diabetic nephropathy,24 men (42.9%) and 32 women (57.1%), aged from 38 to 81 years. The osmolality was measured by freezing point depression on osmomat 030 - D (USA). Glomerular filtration rate (GFR) was calculated by the formula GFR - EPI with subsequent determination of renal functional reserve.
Results. It demonstrated that renal osmoregulatory function provides effective regulation of osmotic homeostasis even in a reduced amount of nephrons, but as the glomerular filtration rate decreses to 30 ml/min, the excretion of osmotically active substances gradually decrease too.
Conclusion. Osmoregulatory disturbances in the renal function in patients with 2 types diabetes depend both on the reduction in GFR, - and on changes in the functional capacity of nephron's tubules.
AUTOMATED QUANTIFICATION OF RENAL FIBROSIS WITH SIRIUS RED: IS A ROUTINE METHOD OF THE KIDNEY BIOPSY EVALUATION?
Authors: Nikolaienko O. , Nepomnyashchy V. 
Published: June 2018

The Aim of our study was to determine the intra- and interobserver variation of the automated quantitative evaluation if cortical interstitial fibrosis performed on kidney biopsy samples stained with Sirius red compared to conventional approaches.
Materials and methods. The range of fibrosis was evaluated on 15 renal biopsies obtained from adult patients with minimal change nephropathy, focal segmental glomerulosclerosis and membranous nephropathy. Different methods of fibrosis measurement were used: the automated quantification of Sirius red stained areas with and without polarization, the computerized quantification of the fibrotic interstitium on trichrome-stained samples and the visual assessment offibrotic tissues using quantitative and semiquantitative approaches on trkhrome and PAMS-stained slides. The intra- and interobserver variation of these methods was performed.
Results. The quantitative evaluation of interstitial fibrosis with Sirius red stain under both polarized and unpolarized light demonstrated nearly perfect inter- and intraobserver reproducibility (ICC=0,85-0,99). Whereas, visual methods had relatively high variance between observations (ICC=0,48-0,66).
Conclusions. The automated quantification of cortical interstitial fibrosis as performed on renal biopsy samples stained with Sirius red has been shown to be a highly accurate approach that could be used as a routine method of the kidney biopsy evaluation.
PREDICTORS OF PROGRESSION OF CHRONIC PYELONEPHRITIS IN CHILDREN
Authors: Lavrenchuk O. V. , Bagdasarova I. V. , Driyanska V.E. , Korol L.V. , Suslova G.D. 
Published: June 2018

Introduction The search for new diagnostic capabilities adverse forecasting of chronic pyelonephritis in children is a pressing issue today. To determine the degree of destruction of renal parenchyma, structural and functional changes in kidney informative study of fermenturiyi, analyze its relationship with albuminuria and profibrozuyuchymy growth factors. The aim was to identify predictors of progression of chronic pyelonephritis in children to assess the level of kidney function in dynamic observation.
Materials and Methods: Pediatric Nephrology at the Department of SI «Institute of Nephrology AMS of Ukraine» at the CST №7 of Kyiv was examined 191 child over 5 years in age from 3 to 17 years.
Results: In the group of children with progressive chronic pyelonephritis relapsing course 2fi-MG urine compared with groups of 2fi-MG there PNhighest level of reliable patients who had not frequent relapses and recovered (p <0.001). To determine infringement tubular renal function, analyzed the $2-MG urine and serum levels with enzyme activity NAG, NAG B and in patients with chronic pyelonephritis and established significant coefficients of paired correlation 2fi-MG serum and urine $2-MG between levels and activity Nag, NagB in urine. Discovered reliable positive correlation between levels of albuminuria and TGF-fi, which is profibrotychnym factor (r = 0,48, p <0.001) and identified a significant increase in its levels in patients with chronic pyelonephritis. Conducted stepwise multiple linear regression analysis revealed a reliable connection between the measure glomerular filtration rate decline per year (which is determined by progression) and $2-MG levels of blood TGF-^, $2-MG in urine, albuminuria and indicators renoscintigraphy - ENPstand% inclusion RFP180 min.
Conclusions. Predictors of progression of pyelonephritis in children are: increased activity of lysosomal enzymes, maintaining elevated levels $2-MG serum and urine regardless of the degree of inflammatory activity in the kidneys and albuminuria
DOPLEROGRAPHIC DESCRIPTION OF RENAL BLOOD SUPPLY DISTURBANCE IN PATIENTS WITH CHRONIC KIDNEY DISEASE STAGE I-II AND ARTERIAL HYPERTENSION
Authors: Zub L.O. , Novychenko S.D. , Novychenko О.І. 
Published: June 2018

The purpose of this work was to investigate renal blood supply disturbance in patients with chronic renal disease stage I-II (pyelonephritis, glomerulonephritis, diabetic nephropathy).
Material and methods. The authors carried out 131 complex ultrasonic investigations using ultrasonic duplex color kidney scanning. 47patients with chronic pyelonephritis (ChPN), 48patients with diabetic nephropathy stage IV (DN) and 36patients with chronic glomerulonephritis (ChGN) were involved into investigation. Each group consisted of 2 subgroups – with arterial hypertension (AH) and without AH. 20 healthy persons were examined as well.
Results. Scantyintrarenal blood flow which is characterized with a decrease of maximal systolic (Vs), minimal diastolic blood velocity(Vd), as well as a decrease of indices of the averaged, according to time, maximal blood velocity (TAMX) and volumetric blood velocity (Vvol) and an increase of index resistance (IR) have been revealed in patients with chronic renal disease (ChRD) stage I-II with the presence of AH stage II. Indices of the vascular renal blood flow under study correlated with the main factors of ChRD progression – glomerular filtration rate (GFR) and daily proteinuria.
Conclusion. Reliable Vs, Vd, TAMX and Vvol decrease and a reliable IR increase may be considered as early noninvasive criteria of ChRD progression with the presence of AH stage II.
THE FEATURES OE CLINICAL AND LABORATORY DIAGNOSIS OF FABRY DISEASE
Authors: Pichkur N O. 
Published: June 2018

The aim of the study was to determine the clinical features and molecular genetic patterns of patients with Fabry disease (FD) to optimize the diagnostic stepwise.
Object and methods. The comparison of clinical features was performed and the activity of lysosomal enzyme a–galactosidase A in the peripheral blood leukocyte homogenate was studied in 120 male with the neuropathic pain or acroparesthesia who contacted the Center of Orphan Diseases of NSCH “Ohmatdyt” in years 2002–2016. The cascade family screening (in 8 people) at low enzyme levels and molecular genetic analysis for the presence of mutations in the GLA gene were performed.
Results. The activity of –galactosidase A was decreased (range 0.5–12.6 nM/mg/h with median 2.0 nM/mg/h) in nine cases (7.5%). All these patients had additional clinical signs (angiokeratoma, hypertrophic cardiomyopathy, coarse facial features, and compromised family tree). The diagnosis of FD were confirmed by the molecular genetic analysis in the GLA gene; there were identified two new mutations (p.739 740delAA and C.945 946delinsTTGA). The other mutations in 6 out of 8 examined families were revealed by the screening of the first kinship degree female relatives, but the activity of –galactosidase A in leukocytes was only reduced in 4 of them.
Conclusion. The multisystem lesions and the difference in the clinical signs of FD complicate the timely formulation of diagnosis. Selective screening among patients with renal insufficiency, cardiac pathology, and ischemic stroke in the anamnesis increases the possibility of FD diagnosis. Cascade family screening of FD patients relatives is highly effective in identification new patients with non–classical form of FD. Inclusion in the selective group of persons with chronic diseases, compromised pedigree, acroparesthesia and additional FD probable clinical signs reduces the range ofpatients for further high–cost testing and optimizes the diagnosis of FD.
Pengaruh Teknik Pernapasan Buteyko terhadap ACT
Authors: Sutrisna Marlin , Pranggono Emmy H , Kurniawan Titis 
Published: June 2018

This study aims to determine the effect of buteyko breathing technique on asthma control test.The quasi experimental study with the pretest and post test one group design approach involved 14 patients with asthma selected from the Lung Polyclinic of Dr. Hasan Sadikin Bandung with consecutive sampling. Asthma control was collected using time series ACT. The collected data were analyzed descriptively and inferentially with the scale of significance p smaller than 0.05.The results showed a significantly higher mean difference between ACT scores after buteyko breathing technique 19.79 more or less 1.47 with ACT score at week III 17.50 moe or less 1.78 week II 12.64 more or less 1.82, week I 9.57 more or less 1.95, and pretest 7.64 more or less 1.82. Post hoc analysis found the fourth week post test score 19.79 more or less 1.47 significantly better than post test week III 17.50 more or less 1.78, week II 12.64 more or less 1.82, week I 9.57 more or less 1.95, and pretest 7.64 more or less 1.82 in improving asthma control. It was concluded that there was an effect of buteyko breathing technique on asthma control test. Thus, the results of this study become important as a study material for nurses at the Hospital in an effort to increase asthma control test.
Keywords: ACT, Breathing Technique, Bronchial Asthma, Buteyko
Pengalaman Ibu dalam Merawat Bayi Preterm yang Pernah dirawat di Ruang Neonatus Intensive Care Unit Kota Bengkulu
Authors: Padila Padila , Amin Muhammad , Rizki Rizki 
Published: June 2018

The purpose of this study was to to explore mothers experience in caring for preterm infants who had been treated in the NICU in Bengkulu. This study used a qualitative design with in depth interviews using open ended questions as a guide. The study was conducted in a patients home in a fairly comfortable space. The sample consisted of five mothers. Data were analyzed using Collaizi method. The results obtained are six themes, namely the mothers description of the characteristics of preterm infants, the cause of preterm birth, the mothers experience in preterm baby care at home, the support the mother receives in preterm infant care, mothers self-coping in the care of preterm infants and reactions mother during caring for preterm baby. The conclusion that can be taken is that mothers experience in caring for preterm baby who had been treated in NICU room of Bengkulu City should be able to pay attention to some obstacles or challenges that need to be considered during home treatment. In general, the mother is able to pass a period of sadness and grief in treating preterm infants or low birth weight.
Keywords:Phenomenology, Mothers Experience,Preterm.
Faktor Faktor yang Mempengaruhi Perilaku Lansia dalam Mengikuti Senam Lansia di Wilayah Kerja Puskesmas
Authors: Novianti Novianti , Mariana Dina 
Published: June 2018

This study aimed to determine the factors that influence the behavior of the elderly in participating in gymnastics for elderly in Jalan Gedang Health Center in Bengkulu City, 2016. This study was an analytical study using cross sectional design. The population were all elderly at gymnastics in Jalan Gedang health center totaled 50 people, with a total sample of 33 people, and were taken using accidental sampling technique. Data collection was done by direct interview using a questionnaire. The data were analyzed using univariate and bivariate analysis with chi square test at α 5 percent. The results showed that most respondents 60.6 percent had less knowledge, most respondents 51.5 percent got lower family support, almost half of respondents 36.4 percent had low motivation, almost half of respondents 42.4 percent behave not active in participating in gymnastics for elderly, and the results of the chisquare value of ρ 0.040, 0.000 and 0.001 showed no relationship between knowledge, family support and motivation to the behavior of the elderly in participating in gymnastics in Jalan Gedang health center in Bengkulu City 2016. Knowledge, family support, and motivation are very important for the elderly in order to follow gymnastics actively, because gymnastics is very useful for maintaining health.
Keywords: Awareness, Behavior, Family Support, and Motivation
Five-year results of a clinical pilot study utilizing a pedicle-lengthening osteotomy for the treatment of lumbar spinal stenosis
Authors: Mlyavykh Sergey , Ludwig Steven C. , Kepler Christopher K. , Anderson D. Greg 
Published: June 2018

OBJECTIVELumbar spinal stenosis (LSS) is a common condition that leads to significant disability, particularly in the elderly. Current therapeutic options have certain drawbacks. This study evaluates the 5-year clinical and radiographic results of a minimally invasive pedicle-lengthening osteotomy (PLO) for symptomatic LSS.METHODSA prospective, single-arm, clinical pilot study was conducted involving 20 patients (mean age 61.7 years) with symptomatic LSS treated by a PLO procedure at 1 or 2 lumbar levels. All patients had symptoms of neurogenic claudication or radiculopathy secondary to LSS, and had not improved after a minimum 6-month course of nonoperative treatment. Eleven patients had a Meyerding grade I degenerative spondylolisthesis in addition to LSS. Clinical outcomes were measured using the Oswestry Disability Index, Zürich Claudication Questionnaire, 12-Item Short Form Health Survey, and a visual analog scale for back and leg pain. Procedural variables, neurological outcomes, adverse events, and radiological imaging (plain radiographs and CT scans) were collected at the 1.5-, 3-, 6-, 9-, 12-, 24-, and 60-month time points.RESULTSThe PLOs were performed through percutaneous incisions, with minimal blood loss in all cases. There were no operative complications. Four adverse events occurred during the follow-up period. Statistically significant improvement was observed in each of the outcome instruments and maintained over the 5-year follow-up period. Imaging studies, reviewed by an independent radiologist, showed no evidence of device subsidence, migration, breakage, or heterotopic ossification. Thin-slice CT scans documented healing of the osteotomy site in all patients at the 6-month time point and an increase of 115% in the mean cross-sectional area of the spinal canal.CONCLUSIONSTreatment of patients with symptomatic LSS with a PLO procedure provided substantial enlargement of the area of the spinal canal and favorable clinical results for both disease-specific and non–disease-specific outcome measures at all follow-up time points out to 5 years. Future research is needed to compare this technique to alternative therapies for LSS.
Prediction of recovery from supplementary motor area syndrome after brain tumor surgery: preoperative diffusion tensor tractography analysis and postoperative neurological clinical course
Authors: Oda Kazunori , Yamaguchi Fumio , Enomoto Hiroyuki , Higuchi Tadashi , Morita Akio 
Published: June 2018

OBJECTIVEPrevious studies have suggested a correlation between interhemispheric sensorimotor networks and recovery from supplementary motor area (SMA) syndrome. In the present study, the authors examined the hypothesis that interhemispheric connectivity of the primary motor cortex in one hemisphere with the contralateral SMA may be important in the recovery from SMA syndrome. Further, they posited that motor cortical fiber connectivity with the SMA is related to the severity of SMA syndrome.METHODSPatients referred to the authors’ neurological surgery department were retrospectively analyzed for this study. All patients with tumors involving the unilateral SMA region, without involvement of the primary motor area, and diagnosed with SMA syndrome in the postoperative period were eligible for inclusion. Preoperative diffusion tensor imaging tractography (DTT) was used to examine the number of fiber tracts (NFidx) connecting the contralateral SMA to the ipsilateral primary motor area via the corpus callosum. Complete neurological examination had been performed in all patients in the pre- and postoperative periods. All patients were divided into two groups: those who recovered from SMA syndrome in ≤ 7 days (early recovery group) and those who recovered in ≥ 8 days (late recovery group). Differences between the two groups were assessed using the Student t-test and the chi-square test.RESULTSEleven patients (10 men, 1 woman) were included in the study. All patients showed transient postoperative motor deficits because of SMA syndrome. Tractography data revealed NFidx from the contralateral SMA to the ipsilateral primary motor area via the corpus callosum. The mean tumor volume (early 27.87 vs late 50.91 cm3, p = 0.028) and mean NFidx (early 8923.16 vs late 4726.4, p = 0.002) were significantly different between the two groups. Fisher exact test showed a significant difference in the days of recovery from SMA syndrome between patients with an NFidx > 8000 and those with an NFidx < 8000.CONCLUSIONSDiffusion tensor imaging tractography may be useful for predicting the speed of recovery from SMA syndrome. To the authors’ knowledge, this is the first DTT study to identify interhemispheric connectivity of the SMA in patients with brain tumors.
Full-endoscopic uniportal decompression in disc herniations and stenosis of the thoracic spine using the interlaminar, extraforaminal, or transthoracic retropleural approach
Authors: Ruetten Sebastian , Hahn Patrick , Oezdemir Semih , Baraliakos Xenophon , Merk Harry , Godolias Georgios , Komp Martin 
Published: June 2018

OBJECTIVESurgery for thoracic disc herniation and spinal canal stenosis is comparatively rare and often challenging. Individual planning and various surgical techniques and approaches are required. The key factors for selecting the technique and approach are anatomical location, consistency of the pathology, general condition of the patient, and the surgeon’s experience. The objective of the study was to evaluate the technical implementation and outcomes of a full-endoscopic uniportal technique via the interlaminar, extraforaminal, or transthoracic retropleural approach in patients with symptomatic disc herniation and stenosis of the thoracic spine, taking specific advantages and disadvantages and literature into consideration.METHODSBetween 2009 and 2015, decompression was performed in 55 patients with thoracic disc herniation or stenosis using a full-endoscopic uniportal technique via an interlaminar, extraforaminal, or transthoracic retropleural approach. Imaging and clinical data were collected during follow-up examinations for 18 months.RESULTSSufficient decompression was achieved in the full-endoscopic uniportal technique. One patient required revision due to secondary bleeding, and another exhibited persistent deterioration on myelopathy. No other serious complications were observed. All but one patient experienced regression or improvement of their symptoms.CONCLUSIONSThe full-endoscopic uniportal technique with an interlaminar, extraforaminal, or transthoracic retropleural approach was found to be a sufficient and minimally invasive method. To cover the entire range of thoracic disc herniations and stenosis within the criteria named, all full-endoscopic approaches are required.