bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graphene Paper with Sharp‐edged Nanorods of Fe−CuMOF as an Excellent Electrode for the Simultaneous Detection of Catechol and Resorcinol
Authors: Kıranşan Kader Dağcı , Topçu Ezgi 
Published: August 2019

AbstractA flexible composite paper Fe−Cu‐based metal‐organic framework (MOF)/reduced graphene oxide (rGO) (Fe−CuMOF/rGO) electrode was prepared by using a simple electrochemical method for the simultaneous detection of catechol (CC) and resorcinol (RC). Free‐standing, flexible and double‐sided Fe−CuMOF/rGO composite paper was obtained by applying the electrochemical deposition process on the rGO paper electrode in the solution containing Fe−CuMOF composite. The morphological analysis of Fe−CuMOF/rGO composite paper showed that sea urchin‐like structures formed on the rGO electrode surface consist of numerous sharp‐edged nanorods of Fe−CuMOF. Flexible Fe−CuMOF/rGO paper electrode exhibited high sensitivity, wide linear range and low detection limit for the simultaneous determination of CC and RC. The linear ranges of concentration for CC and RC were 0.1–800 and 0.1–720 μM, respectively, and the corresponding limits of detection (S/N=3) were 0.016 and 0.020 μM. The outstanding performance of this flexible electrode could be attributed to the sharp‐edged urchin‐like Fe−CuMOF structures which provide an increment of the surface area and the electrochemical activity of the composite paper electrode. Stability tests showed that Fe−CuMOF/rGO composite paper electrode has excellent flexibility, high durability, and good reproducibility. Furthermore, this electrode exhibited high sensitivity and selectivity for the determination of CC and RC in real sample analysis.
Analysis of four therapeutic monoclonal antibodies by online capillary isoelectric focusing directly coupled to quadrupole time‐of‐flight mass spectrometry
Authors: Wang Lingyu , Chen David Da Yong 
Published: August 2019

AbstractCapillary isoelectric focusing (cIEF) was online coupled to a Q‐TOF MS by a flow‐through microvial interface for the analysis of therapeutic mAb. Intact molecular weights obtained from the mass spectrum deconvolution of separated charge variants provided information on the structural heterogeneity of therapeutic mAbs. A sandwich cIEF–MS configuration composed of anolyte, sample, and catholyte segments sequentially injected into a neutrally coated capillary was used for the charge heterogeneity separation of four mAbs. Acetic acid and ammonium hydroxide were used in places of the non‐volatile acids and bases commonly used for IEF but are incompatible with online MS detection. Glycerol was added as the anti‐convective reagent. A chemical modifier was mixed with the cIEF effluent in the flow‐throw microvial to maintain the ESI stability and to mitigate ion suppression from the co‐eluted carrier ampholytes and glycerol. Analysis of mAb samples have shown relative populations of two basic variants originating from C‐terminal lysine process and acidic variant of deamidation. The lysine clippings, deamidation, and sialic acid modification in oligosaccharide chains were revealed in infliximab. Two lysine clipping variants and a deamidated variant were observed in adalimumab. The duplicate analyses of a reference mAb demonstrated five charge variants separated by cIEF due to some unidentified modifications, as their mass spectra shared close similarities. The mAb analyses demonstrated the feasibility of the cIEF–MS method, and they demonstrated how charge and structural variants and minor differences in therapeutic mAbs are observed with this technology. Online cIEF–MS is an information rich technology with high throughput, demonstrated by the initial data presented here.
Optimization of protein extraction from Chlorella Vulgaris via novel sugaring‐out assisted liquid biphasic electric flotation system
Authors: Koyande Apurav Krishna , Chew Kit Wayne , Lim Jun‐Wei , Lee Sze Ying , Lam Man Kee , Show Pau‐Loke 
Published: August 2019

AbstractMicroalgae biomass has been consumed as animal feed, fish feed and in human diet due to its high nutritional value. In this experiment, microalgae specie of Chlorella Vulgaris FSP‐E was utilized for protein extraction via simple sugaring‐out assisted liquid biphasic electric flotation system. The external electric force provided to the two‐phase system assists in disruption of rigid microalgae cell wall and releases the contents of microalgae cell. This experiment manipulates various parameters to optimize the set‐up. The liquid biphasic electric flotation set‐up is compared with a control liquid biphasic flotation experiment without the electric field supply. The optimized separation efficiency of the liquid biphasic electric flotation system was 73.999 ± 0.739% and protein recovery of 69.665 ± 0.862% compared with liquid biphasic flotation, the separation efficiency was 61.584 ± 0.360% and protein recovery was 48.779 ± 0.480%. The separation efficiency and protein recovery for 5 × time scaled‐up system was observed at 52.871 ± 1.236% and 73.294 ± 0.701%. The integration of simultaneous cell‐disruption and protein extraction ensures high yield of protein from microalgae. This integrated method for protein extraction from microalgae demonstrated its potential and further research can lead this technology to commercialization.
When UAVs coexist with manned airplanes: Large‐scale aerial network management using ADS‐B
Authors: Pan Yan , Li Shining , Li Bingqi , Bhargav B. , Ning Zeyu , Han Qingye , Zhu Ting 
Published: August 2019

AbstractIncreasing attention has been paid to employing the Automatic Dependent Surveillance‐Broadcast (ADS‐B) technology on unmanned area vehicles (UAVs). The critical challenge therefore emerges, ie, how to effectively schedule the UAVs without interfering the communication. An UAV management framework named uFly is proposed to address this challenge by controlling the total ADS‐B communication traffic over the air. The ADS‐B's interference probability is first modeled. Based on this model, the UAVs' ADS‐B traffic (as well as the number of flying UAVs) should match the manned airplanes' signals. By taking the manned airplanes' signals as the first‐class constraint, uFly then dynamically approves or denies UAVs for flight based on the real‐time number of airplanes. Finally, experiments using different data sets are conducted to verify the superior performance of uFly.
Integrating Entrepreneurship and Art to Improve Creative Problem Solving in Fisheries Education
Authors: Jacobson Susan K , Seavey Jennifer , Goodman Janis , Nichols Owen C , Williams Lindsey C , Márquez-García Marcela , Barbosa Olga 
Published: August 2019

Abstract
We adapted instructional activities from entrepreneurship and art training to improve student skills in creative problem solving in fisheries and natural resource fields. The teaching module included: (1) individual exercises that apply specific thinking strategies to improve originality, flexibility, and fluency for creative thinking; (2) group exercises using an entrepreneurial business framework for collaborative, creative problem solving that focuses on effective brainstorming and decision making; and (3) art inquiry experiences centered on creating emojis to help students explore and communicate their experiences in the field. These techniques were introduced and practiced during an undergraduate sustainable fisheries field course to creatively address topics ranging from reducing bycatch in fishing gear to sustainable fisheries management, and repeated in a graduate-level short course for students in natural resources. Evaluation of student learning showed significant improvement in pre- and post-originality scores, class performance, and positive student and faculty feedback.
A novel RBMX‐TFE3 gene fusion in a highly aggressive pediatric renal perivascular epithelioid cell tumor
Authors: Argani Pedram , Zhang Lei , Sung Yun‐Shao , White Marissa J. , Miller Karin , Hopkins Mark , Small Donald , Pratilas Christine A. , Swanson David , Dickson Brendan , Antonescu Cristina R. 
Published: August 2019

AbstractWe report an Xp11 translocation perivascular epithelioid cell tumor (PEComa) with a novel RBMX‐TFE3 gene fusion, resulting from a paracentric X chromosome inversion, inv(X)(p11;q26). The neoplasm occurred in an otherwise healthy 12‐year‐old boy who presented with a large left renal mass with extension into the inferior vena cava. The patient was found to have multiple pulmonary metastases at diagnosis and died of disease 3 months later. The morphology (epithelioid clear cells with alveolar and nested architecture) and immunophenotype (TFE3 and HMB45 strongly positive; actin, desmin, and PAX8 negative) was typical of an Xp11 translocation PEComa; however, TFE3 rearrangement was initially not detected by routine TFE3 break‐apart fluorescence in situ hybridization (FISH). Further RNA sequencing revealed a novel RBMX‐TFE3 gene fusion, which was subsequently confirmed by fusion assay FISH, using custom design RBMX and TFE3 come‐together probes. This report describes a novel TFE3 gene fusion partner, RBMX, in a pediatric renal PEComa patient associated with a fulminant clinical course. As documented in other intrachromosomal Xp11.2 inversions, such as fusions with NONO, RBM10, or GRIPAP1 genes, the TFE3 break‐apart might be below the FISH resolution, resulting in a false negative result.
Continuity of the Western Qinling and Qaidam‐Qilian blocks: Evidence from Precambrian and Permian–Triassic strata around the Gonghe Basin area, NW China
Authors: Li Dapeng , Chen Yuelong , Zhou Jian , Kang Huan , Hou Kejun 
Published: August 2019

Tectonic affinity between the Qaidam‐Qilian Block and the Western Qinling Block is an outstanding issue that has not been fully understood. Detrital zircon U–Pb dating and Hf isotope data for the Precambrian and Permian–Triassic strata around the Gonghe Basin area in both the Western Qinling and Qaidam‐Qilian blocks were studied. Detrital zircons from Precambrian strata range in age from Archean to Late Neoproterozoic, with age peaks at ~2.7–2.5, ~1.8–1.6, and ~0.95–0.75 Ga. Except for Precambrian age groups, Early Palaeozoic (550–500 Ma and ~450 Ma) and Late Palaeozoic–Triassic (~250 Ma) age peaks were also detected in the Triassic strata. The juvenile accreted crustal materials were detected at 1.85–1.5 Ga and over ~2.5 Ga based on zircon Hf isotope studies. Different Precambrian and Triassic strata in both the Western Qinling Block and the Qaidam‐Qilian Block show parallel age distribution patterns and Hf isotopes. A Qaidam‐Qilian source contributed to the majority of detritus in Precambrian strata. Besides sources from the Qaidam‐Qilian Block, Late Permian intrusions around the Gonghe Basin area also provided inputs for the Triassic strata. Detrital zircon studies show a strong connection of the Qaidam‐Qilian Block and the majority of detritus in the Gonghe Basin area of the Western Qinling Block. Tectonomagmatic and provenances comparison of the Western Qinling and Qaidam‐Qilian blocks are supportive of their tectonic continuity at least in three stages, that is, in the Precambrian, Middle Palaeozoic, and Permian to Early Triassic.
Effects of jaw exercise intervention timing on outcomes following oral and oropharyngeal cancer surgery: Pilot study
Authors: Sandler Mykayla L. , Lazarus Cathy L. , Ru Meng , Sharif Kayvon F. , Yue Lauren E. , Griffin Martha J. , Likhterov Ilya , Chai Raymond L. , Buchbinder Daniel , Urken Mark L. , Ganz Cindy 
Published: August 2019

AbstractBackgroundCommon in head and neck cancer patients, trismus can make speech and swallowing difficult and can compromise quality of life (QOL). Jaw range of motion exercise therapy may prevent or treat trismus in surgical patients. While the importance of these exercises is well‐documented, there is little literature regarding the optimal timing of exercise initiation.MethodsA prospective pilot study investigated the effects of early vs late jaw exercise intervention on postoperative jaw opening and QOL measures, which were examined descriptively.ResultsTiming of exercise intervention was not found to significantly impact the measured outcomes. However, provisional, descriptive findings showed that jaw opening was significantly associated with multiple QOL measures, with greater jaw opening associated with improved QOL. For certain QOL measures, this positive association was stronger at earlier time points than at later time points.ConclusionsThe exploratory findings of this pilot study support further research into possible benefits of early jaw exercise intervention.
Development of a Plasma Screening Panel for Pediatric Nonalcoholic Fatty Liver Disease Using Metabolomics
Authors: Khusial Richard D. , Cioffi Catherine E. , Caltharp Shelley A. , Krasinskas Alyssa M. , Alazraki Adina , Knight‐Scott Jack , Cleeton Rebecca , Castillo‐Leon Eduardo , Jones Dean P. , Pierpont Bridget , Caprio Sonia , Santoro Nicola , Akil Ayman , Vos Miriam B. 
Published: August 2019

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children, but diagnosis is challenging due to limited availability of noninvasive biomarkers. Machine learning applied to high‐resolution metabolomics and clinical phenotype data offers a novel framework for developing a NAFLD screening panel in youth. Here, untargeted metabolomics by liquid chromatography–mass spectrometry was performed on plasma samples from a combined cross‐sectional sample of children and adolescents ages 2‐25 years old with NAFLD (n = 222) and without NAFLD (n = 337), confirmed by liver biopsy or magnetic resonance imaging. Anthropometrics, blood lipids, liver enzymes, and glucose and insulin metabolism were also assessed. A machine learning approach was applied to the metabolomics and clinical phenotype data sets, which were split into training and test sets, and included dimension reduction, feature selection, and classification model development. The selected metabolite features were the amino acids serine, leucine/isoleucine, and tryptophan; three putatively annotated compounds (dihydrothymine and two phospholipids); and two unknowns. The selected clinical phenotype variables were waist circumference, whole‐body insulin sensitivity index (WBISI) based on the oral glucose tolerance test, and blood triglycerides. The highest performing classification model was random forest, which had an area under the receiver operating characteristic curve (AUROC) of 0.94, sensitivity of 73%, and specificity of 97% for detecting NAFLD cases. A second classification model was developed using the homeostasis model assessment of insulin resistance substituted for the WBISI. Similarly, the highest performing classification model was random forest, which had an AUROC of 0.92, sensitivity of 73%, and specificity of 94%. Conclusion: The identified screening panel consisting of both metabolomics and clinical features has promising potential for screening for NAFLD in youth. Further development of this panel and independent validation testing in other cohorts are warranted.
An assessment of program evaluation methods and quality in Australian prevention agencies
Authors: Schwarzman Joanna , Nau Tracy , Bauman Adrian , Gabbe Belinda J. , Rissel Chris , Shilton Trevor , Smith Ben J. 
Published: August 2019

AbstractIssue addressedThis study aimed to examine evaluation methods and quality in Australian health promotion agencies and the factors associated with this. The evidence base for prevention strategies is limited, with the evidence generated through program evaluation by health promotion and disease prevention agencies lacking rigour. Despite the need to improve the quality of evaluation, there is limited evidence of what influences evaluation quality in the prevention field.MethodsData were collected using the Evaluation Practice Analysis Survey and an audit and appraisal of evaluation reports. Descriptive analysis was used to examine evaluation characteristics and multivariable regression was used to explore the association between evaluation and organisational attributes and evaluation quality.ResultsIn total, 392 evaluation reports were reviewed from 78 government and non‐government agencies. Process evaluation was conducted most frequently, followed by impact evaluation. Overall evaluation quality was low (median 24.5%). In multivariable regression analysis, only two factors were associated with evaluation quality: health promotion budget (ratio of geometric means 1.53 [95% CI 1.02‐2.29]); and, conducting statewide or national prevention programs (1.38 [95% CI 1.05‐1.82]).ConclusionsThe findings show that the potential to improve evaluation quality is greatest in smaller organisations that deliver health promotion at a local or regional scale.So what?By improving the rigour of existing evaluation, there is opportunity to build the evidence base for prevention strategies, which highlights the importance of embedding the enablers of program learning and evidence generation within health promotion and prevention organisations.
Analysis of heat conduction inside the nip of a machine calender for the same and different roll temperatures
Authors: Kanth Neel , Ray A. K. 
Published: August 2019

AbstractCalendering is a mechanical leveling and segmenting process at the final stage in many industries, like paper, printing, leather, and textile, where a thin sheet of material passes through the nips formed by two or more rolls in contact. The material composition of rolls varies for different types of calenders. Depending on the quality of products required for the end usage, the rolls can be hard or soft. Furthermore, they may be heated to a certain degree of temperature, using different heat transfer processes, such as induction, hot water passage, or heated oil passage. In this paper, the effect of roll temperature and time of contact (dwell time) on the temperature of newsprint paper in the thickness direction has been discussed using a single hard nip calender (machine calender), when the paper web is inside the calender nip formed by two rolls having the same and different temperature levels. The case of temperature gradient calendering has also been discussed.
Impact of Electric Vehicles on Indirect Carbon Emissions and the Role of Engine Posttreatment Emission Control Strategies
Authors: Kurien Caneon , Srivastava Ajay Kumar 
Published: August 2019

Abstract
Electricity generation in developing countries is dependent on fossil fuel–based thermal power plants, and the introduction of electric vehicles will only shift the threat of emissions from the operation stage to the energy generation stage. India is one of the developing countries in South Asia where fossil fuel–based power plants make major contributions to electricity generation. In this paper, a detailed review of the challenges faced by electric vehicles is discussed, and an analysis was conducted on the equivalent C emissions from electric vehicles by considering 3 scenarios in India: 1) current electricity generation, 2) power generation considering the installed capacity, and 3) Vision 2022. Based on these 3 scenarios, the main objectives of this work are to understand the potential of electric vehicles to reduce the overall C emissions after considering the indirect C emissions from electricity generation and to highlight the importance of emission control techniques. Experimental investigations of the conversion efficiency of diesel oxidation catalysis (DOC) systems have been conducted for comparative studies. The results of the analysis showed that the indirect C emissions from electric vehicles are higher than the C emissions from internal combustion engines for scenarios 1 and 2. In scenario 3, the C emissions from electric and fossil fuel–powered vehicles are found to be in the same range. The DOC system had an average conversion efficiency of 56% for hydrocarbons and 59% for particle number emissions. The posttreatment emission control systems in internal combustion engines will be the best possible solution, compared to electric vehicles, for reducing overall vehicular emissions until renewable energy sources have a major share in electricity generation. Integr Environ Assess Manag 2020;16:234–244. © 2019 SETAC
Characteristics, management and outcomes of very preterm triplets in 19 European regions
Authors: Dudenhausen Joachim W. , Misselwitz Björn , Piedvache Aurelie , Maier Rolf F. , Weber Tom , Zeitlin Jennifer , Schmidt Stephan ,   the EPICE Research Group
Published: August 2019

AbstractObjectiveTo describe obstetrical care and in‐hospital outcomes in very preterm triplet pregnancies in a European multiregional cohort.MethodsData from a prospective population‐based study of very preterm births between 22 + 0 and 31 + 6 weeks of gestation in 19 regions from 11 European countries participating in the EPICE project in 2011/2012 were used to describe triplet pregnancies and compare them with twins and singletons.ResultsTriplets constituted 1.1% of very preterm pregnancies (97/8851) and 3.3% of very preterm live births (258/7900); these percentages varied from 0% to 2.6% and 0% to 6% respectively across the regions. In‐hospital mortality after live birth was 12.4% and did not differ significantly from singletons or twins or by birth order. However, 28.9% of mothers with a triplet pregnancy experienced at least one neonatal death. Ninety percent of live‐born triplets were delivered by cesarean. Vaginal delivery was associated with an Apgar score of less than 7, but not with in‐hospital mortality.ConclusionsThe prevalence of very preterm triplets varies across European regions. Most triplets were born by cesarean and those born vaginally had lower Apgar scores. Overall, in‐hospital mortality after live birth was similar to singletons and twins.
MFG‐E8 regulates inflammation and apoptosis in tendon healing, and promotes tendon repair: A histological and biochemical evaluation
Authors: Shi Zhengzhou , Zhang Youbo , Wang Qi , Jiang Dapeng 
Published: August 2019

AbstractSeveral studies have identified potential roles for MFG‐E8 in promoting tissue repair. However, the effects of MFG‐E8 on tendon repair have not yet been investigated. Therefore, we explored the role of MFG‐E8 on tendon repair using a rat model of patellar tendon injury. The patellar tendons of Sprague Dawley rats (n = 24/group) received window defects and, after modeling, three groups were randomly assigned: (a) recombinant MFG‐E8 (rMFG‐E8) group, implantation with MFG‐E8 and fibrin glue (400 ng in 10 μl); (b) fibrin group, implantation with fibrin only; and (c) control group, without any treatment. Histopathology, immunohistochemistry, and gene expression analyses were performed at 2 and 4 weeks after healing. Administration of rMFG‐E8 in injury sites significantly improved tendon healing histologically at 4 weeks after injury. In addition, numbers of M1 macrophages and M1‐stimulator genes, including IFNG, Il‐1B, and Il‐6, were reduced in the repair sites at 2 weeks by rMFG‐E8 administration. In parallel, rMFG‐E8 significantly increased the number of M2 macrophages and expression of anti‐inflammatory IL‐10 and IL‐4 at 2 weeks after injury. Treatment with rMFG‐E8 markedly decreased tendon cell apoptosis. Moreover, rMFG‐E8 significantly enhanced the expression of genes related to tendon matrix formation at 2 weeks after injury, including Col1a1and tenascin‐C. We conclude that MFG‐E8 could regulate inflammatory responses and apoptotic cell accumulation in tendon repair, and promote the healing process of injured tendon tissue. Thus, exogenous application of MFG‐E8 might have therapeutic potential for repair of tendon injuries.