bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender difference in clinical conditions among hospitalized adults with myotonic dystrophy
Authors: Ouyang Lijing , Wang Yinding , Valdez Rodolfo , Johnson Nicholas , Gutmann Laurie , Street Natalie , Bolen Julie 
Published: December 2018

ABSTRACTIntroduction: In this study we examined gender differences in adult hospitalizations with myotonic dystrophy (DM).Methods: From the Nationwide Inpatient Sample (NIS) 2010–2014, we identified 1,891 adult hospitalizations with a DM diagnosis and constructed a comparison group of hospitalizations without DM using propensity score matching. We calculated relative risk by gender for 44 clinical diagnoses that each accounted for at least 5% of DM hospitalizations.Results: Hospitalizations with DM were longer (4.8 vs. 4.1 days,P< 0.0001) and more costly ($13,241 vs. $11,458,P< 0.0001) than those without DM. More than half (25 of 44) of the conditions co‐occurring with DM hospitalizations did not differ in their relative risks by gender. For those that differed by gender, only 5 were specific to DM, compared with hospitalizations without DM.Discussion: Our findings highlight the importance of comprehensive and coordinated care for DM rather than gender‐oriented care in the inpatient setting.Muscle Nerve59:348–353, 2019
Age and multiparity related urethral sphincter muscle dysfunction in a rabbit model: Potential roles of TGF‐β and Wnt‐β catenin signaling pathways
Authors: Rajasekaran Mahadevan R. , Fu Johnny , Nguyen My‐Uyen (Lilly) , Wang Yaozhi , Albo Michael , Bhargava Valmik 
Published: December 2018

AimsPrior studies demonstrate increased incidence of urinary incontinence (UI) in the geriatric population which affects their quality of life. Pathophysiology of UI in the geriatric population and the underlying molecular mechanisms are still unclear. To elucidate these mechanisms, we performed a pre‐clinical study in a rabbit model and the objectives were to (i) determine the effect of aging as well as multiparity on urethral sphincter muscle thickness and urethral closing pressure (UCP); (ii) examine the role of fibrosis and atrophy; and (iii) elucidate the molecular pathways that mediate fibrosis and atrophy in the urethral tissue.MethodsNew Zealand White female rabbits (n = 6 each; young 6‐12 months and old over 30 months of age) were anesthetized and urethral muscle thickness and sphincter closure function were measured. Rabbits were then sacrificed and urethral tissues (bladder neck and mid‐urethra) were collected to process for immunostaining as well as for molecular studies for markers for fibrosis (β‐catenin which is an important mediator of Wnt signaling, Collagen‐1, and TGF‐β) and atrophy (MuRF‐1).ResultsOur studies showed a significant decrease in the urethral sphincter muscle thickness and closure function with age. Age‐related increase in protein and mRNA expression levels of fibrosis, as well as atrophy markers were observed in the bladder neck and mid‐urethral tissues.ConclusionsAge and multiparity related increase in fibrosis and atrophy of urethral sphincter muscles may contribute to impaired urethral closure function seen in old animals.
Efficacy and safety of artificial urinary sphincter (AUS): Results of a large multi‐institutional cohort of patients with mid‐term follow‐up
Authors: Tutolo Manuela , Cornu Jean‐Nicolas , Bauer Ricarda M. , Ahyai Sascha , Bozzini Giorgio , Heesakkers John , Drake Marcus J. , Tikkinen Kari A.O. , Launonen Ene , Larré Stéphane , Thiruchelvam Nikesh , Lee Richard , Li Philip , Favro Michele , Zaffuto Emanuele , Bachmann Alexander , Martinez‐Salamanca Juan I. , Pichon Thomas , De Nunzio Cosimo , Ammirati Enrico , Haab Francois , Van Der Aa Frank 
Published: December 2018

AimsTo assess efficacy and safety as well as predictive factors of dry rate and freedom from surgical revision in patients underwent AUS placement. The artificial urinary sphincter (AUS) is still considered the standard for the treatment of moderate to severe post‐prostatectomy stress urinary incontinence (SUI). However, data reporting efficacy and safety from large series are lacking.MethodsA multicenter, retrospective study was conducted in 16 centers in Europe and USA. Only primary cases of AUS implantation in non‐neurogenic SUI after prostate surgery, with a follow‐up of at least 1 year were included. Efficacy data (continence rate, based on pad usage) and safety data (revision rate in case of infection and erosion, as well as atrophy or mechanical failure) were collected. Multivariable analyses were performed in order to investigate possible predictors of the aforementioned outcomes.ResultsEight hundred ninety‐two men had primary AUS implantation. At 32 months mean follow‐up overall dry rate and surgical revision were 58% and 30.7%, respectively. Logistic regression analysis showed that patients without previous incontinence surgery had a higher probability to be dry after AUS implantation (OR: 0.51, P = 0.03). Moreover institutional case‐load was positively associated with dry rate (OR: 1.18; P = 0.005) and freedom from revision (OR: 1.51; P = 0.00).ConclusionsThe results of this study showed that AUS is an effective option for the treatment of SUI after prostate surgery. Moreover previous incontinence surgery and low institutional case‐load are negatively associated to efficacy and safety outcomes.
[3 + 2] cycloaddition reaction ofN,N′cyclic azomethine imines toward highly electron‐deficient nitroalkenes: A molecular electron density theory study
Authors: Babazadeh Sayyed Mohsen , Emamian Saeedreza , Zahedi Ehsan 
Published: December 2018

AbstractA molecular electron density theory (MEDT) study at the M06‐2X/6‐31G(d,p) computational level was performed over [3 + 2] cycloaddition (32CA) reaction of azomethine imine2(AI‐2) toward highly electron‐deficienttrans‐β‐nitrostyrene3(NS‐3) in dimethyl sulfoxide at 110°C. While this reaction can take place through two N3‐C4 and N3‐C5 regioselective reaction channels, in excellent agreement with the experimental outcomes, the calculated rate constants reveal that the N3‐C4 regioselective reaction channel leading to [3 + 2] cycloadductCA‐1nin a highendostereoselective fashion is entirely preferred over the N3‐C5 one. Analysis of the electrophilic and nucleophilic Parr functions computed at the reactive sites of separate reagents allows to explain N3‐C4 regioselectivity, while theendostereoselectivity can be rationalized through non‐covalent interaction analysis in the competitive transition state structures. The electron localization function analysis performed along thestepwiseformation ofCA‐1npermits to figure out the molecular mechanism of zwitterionic type (zw‐type) 32CA reaction betweenAI‐2andNS‐3. Indeed, within the N3 nucleophilic attack ofAI‐2at the electrophilically activated C4 atom ofNS‐3, the first N3‐C4 single bond at intermediateIN‐1nis formed through donation of part of non‐bonding electron density of the N3 nitrogen atom in AI moiety to the C4 carbon atom of NS moiety. In the subsequent step, the formation of the second C1‐C5 single bondviaC1‐to‐C5 coupling of thesepseudoradicalcenters closes the five‐membered ring inCA‐1n. Thestepwiseformation ofCA‐1nshould be related to the highly polar character of the studied reaction.
An investigation of atropisomerism in ortho‐imide substituted 1,3‐benzoxazine by experimental NMR and DFT calculations
Authors: Zhang Kan , Liu Yuqi , Shang Zhikun , Evans Corey J. , Yang Shengfu 
Published: December 2018

AbstractA new type of atropisomerism in ortho‐imide functional 1,3‐benzoxazine compound was evident from nuclear magnetic resonance (NMR) spectra, which showed constant branching ratio of the two products at different measurement temperatures of NMR. Density functional theory calculations were performed to obtain molecular‐level insights into the atropisomerism, which suggested that the reaction intermediate, ortho‐imide phenol, determines the branching ratio of the products. Our calculations showed a large energy barrier after deprotonation of this molecule, which prevents any configurational switch in the follow‐on reactions. Potentially, the atropisomerization mechanism discovered in this work can be used as a generic design principle for improving drug development, organic catalysts, molecular electronics, and other fields wherever atropisomers can play important and prevalent roles.
Oxidation of Ni13 clusters
Authors: Schleder Gabriel R. , Fazzio Adalberto , Arantes Jeverson T. 
Published: December 2018

AbstractWe perform ab initio calculations to investigate Ni13 clusters reaction under an oxygen atmosphere. We dynamically evaluate the effect on structural, electronic, and magnetic properties for pristine and oxidated clusters. As oxygen chemisorption increases, the pristine icosahedral cluster tends to adopt a cubic sodium chloride configuration, resistant to further oxidation. Although each chemisorbed O atom draws one electron, the cluster magnetization stays in the 4‐8 μ
B range, with magnetic moment localized at Ni atoms. Oxygen effect on the electronic structure is to hybridize O(p) − Ni(s, d) among low‐lying occupied states and to induce a HOMO‐LUMO gap opening, while also shifting downwards the electronic band edges, making them favorably aligned with photocatalytic reactions.
Simply Constructing Li1.2Mn0.6Ni0.2O2/C Composites for Superior Electrochemical Performance and Thermal Stability in Li–Ion Battery
Authors: Chen Dandan , Xie Dongjiu , Li Guangshe , Zhang Dan , Fan Jianming , Li Baoyun , Feng Tao , Li Liping 
Published: December 2018

AbstractA Co‐free Li‐rich cathode material Li1.2Mn0.6Ni0.2O2 has been successfully modified by conductive acetylene black (CAB) using a simple physical grinding and post annealing process. X‐ray photoelectron spectroscopy (XPS), X‐ray absorption near‐edge structure (XANES) and Fourier transform infrared spectra (FTIR) characterizations show that annealing process leads to the formation of a strong chemical interaction between CAB and Li1.2Mn0.6Ni0.2O2. The modified sample with 5wt% CAB exhibits excellent cycle stability (83.9% capacity retention after 100 cycles at 1 C) and remarkable rate capacity (93.0 mAh g−1 at 10 C). At the same time, the thermal stability of pristine is obviously enhanced by modification with CAB. Such improvement is ascribed to the existence of the strong interaction between Li‐rich oxide and CAB. This work will offer hints for promoting the commercialization of Li‐rich cathodes.
Copper‐Catalyzed Highly Efficient Acetylene‐Mannich Reaction of Secondary Amines, Paraformaldehyde and Terminal Alkynes
Authors: Xu Zheng , Wu Hui , Li Huaigui , Du Zhengyin , Fu Ying 
Published: December 2018

AbstractA Cu(0)‐catalyzed multicomponent reaction of tetrahydroisoquinolines (THIQ), paraformaldehyde and terminal alkynes to form propargylamines is developed. This protocol worked well for other secondary amines too. Acetylene‐Mannich products were obtained in high yields (up to 98% yields). This acetylene‐Mannich reaction is operationally simple, scalable and exhibits high functional‐group tolerance.
Ultra‐low‐power FSK demodulator with frequency‐offset tolerance
Authors: Yin Yadong , Zhang Lihong 
Published: December 2018

An ultra‐low‐power Frequency Shift Keying (FSK) demodulator with frequency‐offset tolerance is designed in 0.18 μm Complementary Metal Oxide Semiconductor (CMOS) process. The demodulator employs a period‐to‐voltage converter to convert the periods of the input FSK‐modulated signal into voltage levels continuously while consuming ultra‐low power. Moreover, a discrete‐time differentiator is adopted to utilize those converted voltages to recover the transmitted data while preventing the carrier‐frequency offset from deteriorating the demodulation performance. As the experimental results indicate, the novel demodulator can tolerate carrier frequency variations up to ±200 kHz in the case of 1 Mbps data rate with a modulation index of 0.32. It needs a signal‐to‐noise ratio of 16.8 dB to achieve 0.1% bit error rate and consumes a current of only about 49.7 μA from a 1.8 V supply. © 2018 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
The reverse logistics helping to reduce costs of raw material in a pressure aluminum casting
Authors: Morais Marcos de Oliveira , Brejão Antonio Sérgio , Araújo Marcelo Bernardino , Neto Pedro Luiz de Oliveira Costa 
Published: December 2018

AbstractThis paper analyzes the influence of an aluminum smelter of reverse logistics on its reuse of domestic raw materials. It also analyzes reverse logistics financial impact on the smelter, and how reverse logistics can help reduce the purchase of raw materials, which optimizes inventory and controls costs. In addition to environmental savings, it is also possible for reverse logistics to make an organization more powerful in the competitive market. This case study was carried out based on a review of the literature on policies, programs, regulations and laws, as well as on related work in reverse logistics, particularly related to the recycling of aluminum recycling. The reverse logistics actions by the company analyzed in this study achieved annual savings (in U.S. dollars [US$]) of US$ 68,437.70. The study shows that a well‐managed reverse logistics program can be effective and can reduce phases within the organization, achieving not only considerable savings in financial resources but also constituting a social responsibility action.
Research on Quantitative Demand of Underground Space Development for Urban Rail Transit Station Areas: A Case Study of Metro Line 1 in Xuzhou, China
Authors: Wu Liming , Xia Haishan , Cao Xiaowei , Zhang Chun , Dai Cheng 
Published: December 2018

Abstract
Under the background of the rapid development of urban rail transit in China, the development demand of urban underground space has also greatly increased especially in the rail transit station areas. In this paper, taking the high-speed railway station area of Xuzhou Metro Line 1 as an example, the underground space development demand evaluation is conducted by considering the principle of urban underground space stock planning, the local underground space development conditions, as well as the special planning of the local urban constructions. Using the Analytic Hierarchy Process (AHP), a specific weight indicator scale is employed after the rationality of different weight indicator scales being compared. And then the weight indicator of different function types, i.e., commercial, parking, road, etc., are calculated and laterly utilized to forecast the recent development demand of underground space in the station area. Moreover, the steps to forecast the underground space development demand in rail transit station area are proposed, which can provide a reference for the forecasting of underground space development demand in the urban rail transit station areas.
The effect of active and passive peer encouragement on adolescent risk‐taking
Authors: Harakeh Zeena , de Boer Anouk 
Published: December 2018

ABSTRACTIntroductionIn this experiment, we investigated the effect of active (pressure) and passive (imitation) peer encouragement on adolescent risk‐taking and assessed gender differences.MethodThe participants performed the Balloon Analogue Risk Task (BART) with the same‐sex e‐confederate. The experiment consisted of a 2 (passive encouragement: no/yes updates about the number of pumps of the e‐confederate) by 2 (active encouragement: no/yes messages received from the e‐confederate) by 2 (gender: girls/boys) by 3 (time: baseline/first message or update/second message or update) mixed design. The participants comprised 138 Dutch secondary‐school students aged 11–19 years old of whom 46% boys. They were assigned to one of the four conditions: 1. neutral (e‐confederate present), 2. passive (two updates received), 3. active (two messages received), or 4. combined (two updates and two messages received).ResultsOnly a significant main effect of passive peer encouragement and a significant interaction effect of passive peer encouragement*time were shown. The participants exposed to passive peer encouragement took significantly more risk compared to other participants. Moreover, adolescent risk‐taking significantly increased after the first and second update compared to baseline (no update).ConclusionThe findings suggest that adolescents are more likely to engage in risk‐taking because of passive rather than active peer encouragement. Thus, communication through text‐based messages in which young people provide information solely about their own risk‐taking may be an important aim of prevention and intervention programs.
Primary Patency Rate of Arteriovenous Fistula Created for Hemodialysis Patients: The Indonesian Experience
Authors: Tjang Yanto Sandy , Sumadi Glenn Joshua 
Published: December 2018

Abstract
Introduction: Clinical practice guidelines endorse the arteriovenous fistula as the preferred form of vascular access. Concerns have been raised regarding its high risk of primary failure. Its estimated primary patency rate varies in the literature. Since most of the current data are from Western countries and information from the developing countries is scarce, we aim to evaluate the primary patency rate of arteriovenous fistula created for hemodialysis patients in our hospital.
Methodology: We analyzed data from all patients undergoing the creation of arteriovenous fistula for hemodialysis at the PGI Hospital Cikini in Jakarta, Indonesia, from January to December 2015. Information needed was retrieved from the medical records. Actuarial patency rate was created by the Kaplan-Meier product-limit method. Differences between curves were compared by means of a log-rank test.
Results: A total of 253 arteriovenous fistula in the upper arm were created in patients requiring hemodialysis. The overall 6-, 12-, and 18-month primary patency rates of arteriovenous fistula created for hemodialysis patients were 88%, 85%, and 79%, respectively. There was a difference in primary patency rate of arteriovenous fistula by gender. The 6- and 12-month primary patency rates of arteriovenous fistula created for male hemodialysis patients were 92% and 89%; the rates for female patients were 81% and 78%, respectively (P = .027).
Conclusions: Careful preoperative patient assessment, optimal surgical techniques, and adequate postoperative care play an important role for the favorable outcome. The primary patency rate in male hemodialysis patients was significantly higher than in female patients.
The Ultrasound Monitoring to the Venous Thromboembolism Associated with Peripherally Inserted Central Catheters in Chemotherapy Patients: A Prospective Cohort Study
Authors: Jianning Wei , Zhimin Wang , Peiyi He , Ping Du , Huang Xiaodan , Xu Ying 
Published: December 2018

Abstract
Objective: To investigate the incidence of peripherally inserted central catheter–related deep venous thrombosis (PRDVT) and their associated risk factors of PRDVT in the oncological patients who received peripherally inserted central catheters.
Methods: This is a prospective and interventional cohort study; enrolled cancer patients had ultrasound-guided peripherally inserted central catheters and followed up by an intensive ultrasound monitoring protocol for 24 weeks. Vascular color Doppler ultrasound was applicated to the prospective evaluation of thrombus every 2 weeks for each patient.
Results: Of all 406 patients (37,490 catheter days), 30.05% of patients (122/406) developed peripherally inserted central catheter–related deep vein thrombosis, with an incidence of 3.25 per 1000 catheter days. Only 1.23% (5/406) peripherally inserted central catheters were removed because of central line associated blood stream infection or accident. The incidence of asymptomatic PRDVT and symptomatic PRDVT were 26.85% (109/406) and 3.2% (13/406) respectively.
Conclusion: The incidence of PRDVT in our hospital was considerable to the published data. Catheter in right upper extremity, tip at subclavian or T 2-4, more than 1 attempt for peripherally inserted central catheter insertion, and radiotherapy were independent predictors of PRDVT in cancer patients. Proactive ultrasound monitoring protocol from insertion to follow-up visits to investigate the incidence of PRDVT in oncological patients should be a routine examination.
Hemodialysis Catheter Insertion Without Chest X-Ray: Review of a 24-Month Study
Authors: Ramirez Chuck , Miranda Shannon , Sager Erica 
Published: December 2018

Abstract
Acute care hemodialysis catheters have traditionally been validated for use through chest X-ray interpretation. This study was implemented to evaluate if hemodialysis catheters can be placed safely and accurately, utilizing an electrocardiogram plus doppler or dual vector positioning system to validate for use. Over a 24-month period hemodialysis catheters were inserted and validated by utilizing a dual vector positioning system instead of chest X-ray. During the study period, 260 hemodialysis catheters were inserted without chest X-ray and validated for use via the dual vector positioning system. An additional 74 inserted catheters required follow-up chest X-rays because of failure to obtain technological validation. During the study period, no patients had a pneumothorax or hemothorax complication subsequent to catheter placement. The use of a dual vector positioning system in this study demonstrated optimal hemodialysis catheter insertion can be done with no X-ray and no increase in mechanical complications.
Ranking, coordination, and global governance: The case of the Access to Medicine Index
Authors: Quak Sander , Heilbron Johan , Meijer Jessica 
Published: December 2018

AbstractAs a case study in the proliferation of global rankings, we examine the initiation, construction of, and response to the Access to Medicine Index, which ranks pharmaceutical companies according to their respective contribution to access to medicine for developing countries. Since it has served as the model for constructing global rankings in the fields of nutrition, seeds, mining, possibly in the future, oil, seafood, mobile internet, and agricultural commodities, and it serves as a blueprint for the development of corporate sustainability benchmarks in line with the United Nations Sustainable Development Goals, its significance goes well beyond public health. From an economic-sociological perspective we argue, first, that rankings can be conceived as symbolic classifications that serve predominantly as market-based coordination devices. To understand the proliferation of global rankings, we argue, secondly, that they are an integral part of the changing balance of power in the domain of global public health consisting of a historical shift from international organizations as the central mode of governance and coordination to a more decentralized and diversified global field structure. This global field is formed by an increasing number and variety of actors, but lacks a central decision-making body. The case of the Access to Medicine Index suggests that a historical-sociological field perspective has analytical advantages over both the micro-analysis of socio-technical devices and macro-level approaches to issues of governance in contemporary capitalism.