bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into the role of hexa-bacterial consortium for bioremediation of soil contaminated with chlorantraniliprole
Authors: Fahmy Mohamed A. , Salem Samir H. , El-Fattah Hassan I. Abd , Akl Behairy A. , Fayez Mohamed , Maher Mohamed , Aioub Ahmed A. A. , Sitohy Mahmoud 
Published: November 2024

AbstractThis study evaluates the efficacy of discrete bacterial consortia in bioremediating sandy loamy soil deliberately contaminated with 20 mg/kg of chlorantraniliprole (CAP). It monitors alterations in total bacterial populations and CO2 emissions, tracking residual CAP levels through UV scanning and HPLC analysis. Six active bacterial degraders (four Bacillus strains (B. subtilis subsp. subtilis AZFS3, B. pumilus AZFS5, B. mojavensis AZFS15, and B. paramycoides AZFS18), one Alcaligenes strain (A. aquatilis KZFS11), and one Pseudomonas strain (P. aeruginosa KZFS4)) were used in single or combined preparations and grown on trypticase soy broth for 24 h at 30 °C before preparing the inoculants and adjusting the bacterial cell count to 107 CFU/dwt g soil. The bacterial consortia were added to the CAP-contaminated soil and incubated for 20 days at 30 °C. The di-, tetra-, and hexa-bacterial consortia recorded the highest levels of viable bacteria, reaching their peak after 3 to 11 days of incubation. Then, they declined to the minimum levels at the end of the 20 days, which coincided with their complete removal of CAP from the soil. At the end of the incubation period (20 days), the CAP was mainly biodegraded, scoring biodegradation rates of 90.05%, 93.65%, and 98.65% for T3, T4, and T5, respectively. This concurred with the highest average CO2 production. Based on the results of the HPLC analysis, the hexa-bacterial consortium T5 demonstrated the highest rate of CAP biodegradation (99.33%) after a 20-day incubation period, resulting in the lowest residual level of CAP in the soil (0.67%). Bioinformatic analysis predicted that the CAP biodegradation pathway reached CO2 and H2O. Under optimized conditions, the hexa-bacteria consortium is the most effective CAP biodegraded and is recommended as an eco-friendly treatment for eliminating CAP pollution in the field.
The HADRIAN novel human–machine interface prototype for automated driving: safety and impact assessment
Authors: Sekadakis Marios , Kallidoni Marianthi , Katrakazas Christos , Trösterer Sandra , Marx Cyril , Moertl Peter , Yannis George 
Published: November 2024

AbstractThe current paper was performed within the HADRIAN project and focuses on exploring the effects of innovative Human–Machine Interface (HMI) prototypes on safety, driving performance, and driver perceptions. Employing driving simulator experiments and questionnaires, this study investigates whether HADRIAN innovative HMI enhances safety and receives positive evaluations from drivers. Specifically, the research centers on a driving simulator experiment that evaluates novel HMI prototypes designed to improve automated driving at SAE Levels 2 or 3. To facilitate HMI assessment, a tailored safety and impact assessment methodology was developed using unique Key Performance Indicators (KPIs). To benchmark and generate a total score for the HADRIAN HMI, data envelopment analysis was deployed based on the aforementioned KPIs. The findings shed light on the influence of HADRIAN HMI innovations on safety and perceived impact when compared to a baseline “state-of-the-art” HMI. Subsequently, a comprehensive discussion unfolds, highlighting the key KPIs that contributed significantly to the safety and perceived impact scores. This method and its outcomes can serve as a valuable resource for other HMI stakeholders, enabling them to employ similar human-centered assessment methodologies to assess the safety and perceived impact of potential HMI configurations.
Long-Term Cerebellar Consequences of Post-traumatic Brain Injury Assessed by MRI With Diffusion Tensor Imaging
Authors: Delmotte Pierre-Romain , Perret Liaudet Bérenger , Torkomian Gregory , Unrung Jean , Cassereau Didier , Debarle Clara , Mathon Bertrand , Perlbarg Vincent , Puybasset Louis , Degos Vincent , Jacquens Alice 
Published: November 2024

BACKGROUND AND OBJECTIVES:
Post-traumatic brain injury (TBI) lesions, which combine brain atrophy and white matter injuries, can lead to progressive post-traumatic encephalopathy. However, the specific involvement of the cerebellum, which participates in cognitive, executive, and sensory functions, has been little studied. The aim of this work was to explore the long-term cerebellar consequences of severe TBI.

METHODS:
In this retrospective study, patients included were hospitalized for a severe TBI and reassessed after discharge with a clinical examination and a MRI with diffusion tensor imaging. Patients were compared with a population of healthy volunteers. For a subgroup of this cohort, we analyzed the evolution of late post-TBI lesions on MRI up to 10 years after TBI.

RESULTS:
Ninety-seven patients reassessed 5 [3; 6] years after the TBI were included. Volume loss was revealed in the whole cerebellum (P = .01) and especially in the anterior lobe (P < .005) with a decrease in grey matter volume (P = 6.10−3). The mean diffusivity was increased in 4 cerebellar areas which are the right lower, right upper, left lower, and left upper cerebellar peduncles while the fractional anisotropy was decreased in all studied areas (P < 10−3). The longitudinal analysis (n = 17 patients) showed no progression of MRI lesions beyond the acute phase.

CONCLUSION:
This work shows that even if direct cerebellar damage is rare, long-term post-TBI cerebellar lesions can be observed. Therefore, clinical correlates of cerebellar lesions should be considered more systematically.
Racial and Socioeconomic Disparities in Traumatic Brain Injury Outcomes: Insights From a Nationwide Analysis
Authors: Lai Hongyin , Ahmad Hunza , Mubashir Talha , Oduguwa Emmanuella , Balogh Julius , West Kelly , Chaudhry Rabail A. , Williams George W. , Maroufy Vahed 
Published: November 2024

BACKGROUND AND OBJECTIVES:
To examine the effects of racial and socioeconomic disparities on clinical outcomes: in-hospital mortality, discharge dispositions, and hospital length of stay (LOS) among patients with traumatic brain injury (TBI) stratified by race and socioeconomic status (SES).

METHODS:
We conducted a retrospective analysis by analyzing the 1995-2015 Nationwide Inpatient Sample database. Adjusted logistic regressions and multinomial logistic regression models with and without propensity score matching were applied to investigate the effects of disparities on clinical outcomes.

RESULTS:
African American and Hispanic patients with TBI had a lower risk of in-hospital mortality, longer hospital LOS, and lower likelihood of being discharged to rehabilitation compared with White patients. The TBI patients with poor SES (pSES) had lower in-hospital mortality and were more likely to leave against medical advice compared with non-pSES TBI patients.

CONCLUSION:
Racial and socioeconomic disparities had significant influences on in-hospital mortality, discharge dispositions, and hospital LOS among the TBI population. Our study observed pSES TBI patients had a lower likelihood of in-hospital mortality than non-pSES patients, which may be partially attributed to the fact that most of the pSES TBI patients were hospitalized in urban teaching hospitals and hospitals with large bed size. In effect, our data suggest that the Social Safety Net of the United States is effective in preventing mortality in patients with TBI.
TOWARDS FAIR DIVISION OF BENEFITS FROM PATENT RIGHTS: REMUNERATION FOR EMPLOYEE-INVENTOR IN POLISH LEGAL SYSTEM AND IN COMPARATIVE CONTEXT
Authors: Krupa-Lipińska Katarzyna 
Published: November 2024

Remuneration for the employee-inventor is the key element to stimulate the development both in business and academic units for the beneficiary of the whole society. The first element that should be taken into consideration in the given analysis is to whom right to obtain patent belong and later - in case the right to patent belong to employer - whether and how employee-inventor should be remunerated. Both of those problems are differently set in different jurisdictions. Polish law adhere to the systems which by statute prescribes right to obtain patent in case of employee inventions to employer and also by statue guarantee remuneration for employee-inventor both in business and academic environment. The conclusion of the article is that despite of the fact that the statutory provisions are reasonably and fairly constructed there in certain elements they are vague and left much space for the internal regulation of economic entities and higher educational institutions, which at the end of the day might change the overall assessment and work better for those entities than for the employees.
FUTURE OF THE EUROPEAN AND EURO-ATLANTIC INTEGRATION OF UKRAINE
Authors: Poshedin Oleh 
Published: November 2024

The study’s purpose was to examine the objectives of European and Euro-Atlantic integration defined in Ukraine’s strategic documents and Annual National Programs under the auspices of the NATO-Ukraine Commission and to demonstrate the impact of the Russian military invasion of Ukraine on European and Euro-Atlantic integration policy. The article uses the method of document analysis to identify phrases and terms that characterise tasks of the European and Euro-Atlantic integration of Ukraine in the strategic documents since the beginning of 2020.This article delves into the strategic documents of Ukraine, which serve as the guiding principles for its European and Euro-Atlantic integration. The EU and NATO documents defining their relations with third countries and Ukraine are studied in particular. The impact of the Russian military invasion of Ukraine launched in February 2022 on European and Euro-Atlantic integration policies is analysed. Due to the methods of synthesis, the processed material is summarised and the final conclusions of the article regarding the future of European and Euro-Atlantic integration of Ukraine are drawn. It was concluded that the success of European integration will depend on the determination of the Ukrainian government to carry out the necessary reforms. Regarding Euro-Atlantic integration, the prospects for NATO membership will be considered solely upon the conclusion of the Russian Federation’s war against Ukraine. The paper aspires to be a part of the effort to fill the existing void in the scientific output on the realism of the tasks set by the Ukrainian authorities in the field of European and Euro-Atlantic integration before the Russian invasion of Ukraine in 2022, as well as the assessment of Ukrainian prospects for membership in the EU and NATO after 2022.
Customer Voice on Two-Sided Platforms: The Effect of Surge Pricing on Customer Complaints
Authors: Xu Linli , Wei Yanhao “Max” , Zhu Yi 
Published: November 2024

Two-sided platforms (e.g., ride-sharing, freelance labor, and lodging) match customers and service providers. Customers can voice their satisfaction level through review/rating systems, which the platforms use to monitor and screen service providers. However, customers may misdirect complaints about platform-level features toward individual service providers. We examine the extent and consequences of this issue in the context of a large ride-sharing platform. We focus on surge pricing as the platform-level feature. Our findings are as follows. First, for an average trip, surge pricing makes it 1.13 times more likely for the driver to receive a complaint (either a low rating or a formal complaint). Second, complaints negatively impact a driver’s future income. Surge-induced complaints offset about 23% of a driver’s immediate gain from the surged fare. Third, after the platform adopted a policy to cap the magnitude of surge prices, the effect of surge on customer complaints reduced. The policy also led to more usage of the platform. The results suggest a close interaction between the pricing and review systems on ride-sharing platforms. More broadly, they point to the importance for online two-sided platforms to identify and address customer complaints about platform-level features that may have been misdirected to service providers. This paper was accepted by Eric Anderson, marketing. Funding: Y. Zhu acknowledges financial support from 3M [Nontenured Faculty Grant]. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2024.4992 .
Nasal cavity fungus ball discovered accidentally: A case report
Authors: Lee Dae-Neung , Lee Dong Hoon , Lim Sang Chul 
Published: November 2024

BACKGROUND
Fungal balls within the nasal cavity are an exceedingly rare clinical entity, typically presenting with nonspecific symptoms or being identified incidentally.
CASE SUMMARY
This report presents an incidental discovery of a fungal ball in the nasal cavity during routine imaging, with no associated clinical symptoms.
CONCLUSION
This case underscores the importance of considering the possibility of asymptomatic presentations of nasal fungal balls, which may be detected incidentally during imaging evaluations.
Ultrasound features of congenital cytomegalovirus infection in the first trimester: A case report
Authors: Chen Xiao-Li , Zhang Li-Qiang , Bai Li-Li 
Published: November 2024

BACKGROUND
Congenital cytomegalovirus (CMV) infection represents a significant public health concern as the most prevalent viral infection in newborns, potentially leading to severe neurological and developmental complications. The majority of cases are asymptomatic and remain undetected during pregnancy due to the absence of effective screening methods.
CASE SUMMARY
A 27-year-old primigravida presented for early pregnancy ultrasound, which revealed an atypical finding: A normal anechoic thalamus appearing hyperechoic on the mid-sagittal view of the fetal head. Subsequent ultrasound examinations during mid and late gestation demonstrated classic intracranial features suggestive of congenital CMV infection. Chromosomal karyotyping and microarray analysis of the fetus yielded no significant abnormalities. Following comprehensive prenatal counseling regarding potential adverse fetal outcomes, the patient elected to continue her pregnancy. She ultimately underwent cesarean delivery at 42 weeks gestation at another facility, resulting in the birth of a female neonate. At five months of age, the infant presented with epilepsy and significant growth and developmental delays.
CONCLUSION
Congenital CMV infection occurs during the first trimester may manifest as hyperechoic thalamus which can be revealed by ultrasound in the mid-saggital view of the fetal head. Future research should investigate the correlation between echogenic thalamus and developmental outcomes, as well as explore early screening techniques for suspected congenital CMV infection cases.
Two-dimensional fetal speckle tracking; a learning curve study for offline strain analysis
Authors: de Vet Chantelle M. , Nichting Thomas J. , Fransen Annemarie F. , van der Woude Daisy A. A. , van der Ven Myrthe , Post Richard A. J. , van Lier Zoé , Oei S. Guid , van Oostrum Noortje H. M. , van Laar Judith O. E. H. 
Published: November 2024

Objectives
Two-dimensional speckle tracking (2D-STE) strain analysis holds promise for assessing fetal cardiac function. Understand the learning curve before introducing 2D-STE into obstetrics is crucial. This study examined the learning curve for offline analysis of fetal left (LV) and right ventricular (RV) global longitudinal strain (GLS) using 2D-STE.

Methods
After 2D-STE training, three trainees (Maternal-Fetal Medicine fellow, OBGYN resident and medical student) analyzed 100 fetal heart clips using 2D-STE to calculate LV- and RV-GLS. Intra-class correlation coefficients (ICC) and Bland-Altman plots were compared GLS values across four sets of 25 clips for each trainee against the expert. Repeated measurements analysis compared GLS score differences between expert and trainees over time and among trainees, adjusting p-values with a Bonferroni correction.

Results
LV-GLS consistency evolved from poor-to-moderate during the first 50 measurements to moderate-to-good during the second 50 for all trainees. RV-GLS consistency evolved from poor-to-moderate during the first 75 measurements to moderate-to-good during the final 25 measurements for the fellow and resident. The student’s RV-GLS consistency was poor during the first 25 measurements, moderate-to good during the second 25 measurements and again poor-to-moderate during the final 50 measurements. Repeated measurements analysis showed a significant decrease in variability of the LV- and RV-GLS score differences between the expert and trainees over time (padj<0.001), which was not significantly different between trainees. Moreover, the mean of those differences were significantly different for all trainees for LV-GLS (padj<0.001) and RV-GLS (padj = 0.029), and did significantly change over time for RV-GLS (padj<0.001) but not for LV-GLS.

Conclusions
A clear learning effect was observed by the significant decrease in variability of the difference in the score between the expert and trainees over time. The consistency of fetal GLS analysis with 2D-STE was generally found to be moderate to good after 100 measurements in trainees.
Současné pohledy na kategorii pohoda (well-being)
Authors: Mareš Jiří 
Published: November 2024

Přehledová studie se věnuje pojmu, jenž vzbuzuje v posledních desetiletích zvýšený zájem odborníků z různých oborů, třebaže jeho základy položili filozofové už v antickém Řecku (viz dva základní přístupy – hedonismus a eudaimonismus). Navíc jde o pojem, pro nějž se obtížně hledá český ekvivalent. Mnozí čeští autoři tento pojem nepřekládají a pracují s celosvětově používaným anglickým termínem well-being. Jiná skupina českých autorů pracuje s termínem pohoda či osobní pohoda. Výklad celé problematiky je rozdělen do osmi částí. První část přibližuje staletou historii pojmu pohoda (well-being) a jeho proměny od antiky až po dnešek. Druhá část shrnuje současné snahy o definování pojmu pohoda a upozorňuje, že odborníci zatím nedospěli ke konsenzu. Třetí část nabízí přehled celého spektra teorií pohody a snaží se vysvětlit, z čeho vycházejí, na co kladou důraz a jak se dají využít. Čtvrtá část je zajímavá tím, že ukazuje, jak se jednotlivé vědní obory navzájem odlišují v chápání pohody a v práci s ní. Pro ilustraci byly vybrány tyto obory: medicína, pedagogika, psychologie, sociologie a nejnovější trend – multidisciplinární přístup. Pátá část přehledové studie prezentuje rozdílné typy pohody, které se v zahraniční odborné literatuře objevují. Naše analýza identifikovala celkem 30 různých typů pohody. Šestá část výkladu se soustřeďuje na diagnostikování pohody. Nabízí soubor 21 dotazníků zjišťujících míru pohody u dětí, adolescentů i dospělých osob. Sedmá část si zvolila téma, které zajímá širokou veřejnost, neboť se zamýšlí nad současnými poznatky o pohodě a nepohodě v prostředí školy. Poslední, osmá část přehledové studie nabízí pohled na intervence, které se snaží zlepšovat úroveň pohody u dětí a adolescentů.
Az orosz hatalmi ambíciók múltja és jelene Afrikában
Authors: Piller Mátyás Mihály 
Published: November 2024

Korunk változó geopolitikai helyzetében kiemelten fontos megértenünk egyes nemzetközi folyamatok működését, így azt is, hogy egy-egy jelenleg is zajló konfliktus gyökerei hol erednek és milyen hatások következtében szöktek szárba. Oroszország és Afrika kapcsolata hosszú múltú, ám nem eleget tárgyalt téma, mely napjainkban ismét aktuálissá vált. A formális és az informális orosz Afrika-politika hatásai 2024-ben jobban érződnek, mint néhány évtizede, és az orosz–ukrán háború következtében a nyugati világ is odafigyel a fejleményekre. Legyen szó akár az afrikai államok belpolitikai helyzetéről, a migráció hozzánk is elérő hatásairól vagy a kontinens élelmiszerellátásáról, Afrika újra és újra megjelenik a sajtóban, bemutatva a globális interdependencia kiterjedtségét és fokát.
Cikkemben igyekszem feltárni az orosz expanziós politika kezdeti tapogatózásait és fejlődését Afrikában, illetve bemutatni a Szovjetunió bukásától napjainkig terjedő időszakot e kapcsolatok rendszerében. Az összeomló Szovjetunió már bevett és újszerű tapogatózásait a lehető leghatékonyabban kívánom áttekinteni és a megfigyelt minták alapján konklúziót levonni.
A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line
Authors: Heydarzadeh Shabnam , Moshtaghie Ali Asghar , Daneshpour Maryam , Hedayati Mehdi 
Published: November 2024

AbstractAims and backgroundCurcumin’s function in affecting cancer metabolic reprogramming remains poorly understood. Herein, we aimed to elucidate a novel link between curcumin and the glucose uptake metabolism and the status of glucose transporters (GLUTs) in the SW1736 cell line derived from anaplastic thyroid cancer.Materials and methodsThe 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test and flow cytometry were employed to test cell viability and cell death. For glucose uptake detection, the ‘glucose oxidase/peroxidase 4-aminoantipyrine’ enzymatic colorimetric assay was applied to measure the direct glucose levels inside the cells. Determination of GLUT1 and GLUT3 mRNA and protein expression in SW1736 cells was performed by qRT-PCR and western blotting. In addition, the scratch wound healing assay was conducted for cell migration.ResultsThe data indicated that curcumin-induced cell death is independent of apoptosis in this type of thyroid cancer cell line. Furthermore, significantly reduced GLUT1 and GLUT3 expression was observed after treatment with curcumin, resulting in the inhibition of glucose uptake (P < 0.05). Scratch assay indicated the inhibition of cell migration in SW1736 cells treated with curcumin (P < 0.05).ConclusionIt can be concluded that GLUTs, as metabolic targets, can be blocked specifically by curcumin for thyroid cancer prevention. Curcumin, as a promising anti-cancer agent, inhibits the growth of SW1736 anaplastic thyroid cancer cells by regulating the glucose uptake pathway and cell death. Altogether, these results suggest that the glucose pathway may be an essential target for therapeutic intervention to sensitize tumor cells to the cell death process by inhibition of glucose transporters.Statement of translational relevanceAs described in our previously published article, ‘Regulators of glucose uptake in thyroid cancer cell lines’, non-oncogene addiction is one of the recent principles of cancer therapy. Moreover, herein, for the first time, we decided to investigate the anti-thyroid cancer effects of a bioactive phytochemical and establish a signaling link between curcumin and the glucose uptake metabolism of anaplastic thyroid cancer cells. This title covers the entire range of the biological sciences, and we attempt to fill the gaps between cell biology, medicine, cancer and plant knowledge. The influence of cancer on human society is indescribable. Human studies are often contradictory around the effects of polyphenols against cancer. We believe that it is important to draw boundaries between the usages of polyphenols in cancer prevention versus cancer treatment. We anticipate that this study’s findings will contribute to a better understanding of the mechanism underlying curcumin’s anti-cancer properties, providing a theoretical foundation for the future clinical application of curcumin-related medications.