bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial Activity Test of Bacteriocin from Lactobacillus brevis, Lactobacillus casei and Lactobacillus plantarum Against Gram Positive Pathogenic Bacteria
Authors: Sari Novi Permata , Sari Rafika , Untari Eka Kartika 
Published: January 2019

Bacteriocin is a secondary metabolite product of lactic acid bacteria (LAB) which have an antimicrobial and potentially as a natural preservative. LAB isolates used in this study were Lactobacillus brevis, Lactobacillus casei and Lactobacillus plantarum. This study aimed to determine the antibacterial activity of bacteriocin produced by each isolate of LAB including the influence of pH and heating variation against Bacillus cereus, Bacillus subtilis and Staphylococcus epidermidis. Antibacterial activity test was done by using disc diffusion method. method. Confirmation test using proteolytic enzyme aimed to analyse that the inhibition zone produced from the activity of bacteriocin. The inhibition zone produced from L. brevis, L. casei and L. plantarum against B. cereus were 15.70, 16.43 and 14.50 mm, against B. subtilis were 13.37, 14.10 and 12.53 mm and against S. epidermidis were 11.37, 14.50 and 12.45 mm. The activity of each bacteriocin decreased with the addition of trypsin and catalase, bacteriocin was active in the pH range of 2-10 and heating temperature of 40-121oC. Statistical test showed that the addition of trypsin, catalase and the variation of pH also heating had significant differences (p<0.05) to antibacterial activity produced by bacteriocin from L. brevis, L. casei and L. plantarum.
MOLECULAR DOCKING STUDIES AND SYNTHESIS OF 3, 4 - DISUBSTITUTED TRIAZOLES AS MYCOBACTERIUM TUBERCULOSIS ENOYL-ACP REDUCTASE AND CYP-51 INHIBITORS
Authors: Dasan Neethu , Babu G. , George Shiny 
Published: January 2019

Objective: To design, synthesize and in vitro antitubercular, antifungal and antioxidant evaluation of some novel mercapto 1, 2, 4–triazole derivatives.Methods: New derivatives were designed by using various software like ACD Lab chemsketch, molinspiration and autodock. Designed molecules are obeying Lipinski’s rule of five and having highest binding score was selected for the synthesis. The synthesized compounds were subjected to TLC, melting point determination, FTIR, 1H NMR, 13C NMR and mass spectral analysis. The newly synthesized compounds were investigated for in vitro antitubercular evaluation by MABA method, antifungal evaluation by cup plate method and antioxidant evaluation by DPPH scavenging assay.Results: A virtual screening was carried out through docking designed compounds into the InhA and CYP-51 binding site to predict if these compounds have an analogous binding mode of the enoyl ACP reductase (InhA) and CYP-51 inhibitors. Three derivatives (4a1, 4a2 and 4a3) were selected for the synthesis with the help of in silico modeling. The selected derivatives were synthesized by a conventional method. All the synthesized compounds showed a characteristic peak in FT IR, 1H and 13C NMR and mass spectroscopic studies. All the selected derivatives showed antitubercular, antifungal and antioxidant activity.Conclusion: The derivatives were synthesized adopting simple and laboratory friendly reaction conditions to give the target compounds in quantitative yields. Newer derivatives possess good antitubercular, antifungal and antioxidant activity.
ANALYTICAL METHOD DEVELOPMENT FOR SIMULTANEOUS DETERMINATION OF UBIDECARENONE AND VITAMIN E ACETATE IN CAPSULE DOSAGE FORM BY HPLC
Authors: Grace A. Caroline , Prabha T. , Jagadeeswaran M. , Srinivasan K. , Sivakumar T. 
Published: January 2019

Objective: To develop and validate a new simple, accurate, precise and sensitive high performance liquid chromatographic method (HPLC) method for simultaneous estimation of ubidecarenone and vitamin E acetate in capsule dosage form as per international conference on harmonization (ICH) guidelines.
Methods: The chromatographic separation of drugs were achieved using hypersil C8 column (250 mm x 4.6 mm, 5µ) in isocratic elution mode with a mobile phase of methanol: ethanol: n-hexane (80:10:10 v/v/v) at a flow rate of 1 ml/min with ultra-violet (UV) detection at 210 nm.
Results: The optimized method produced sharp peaks with good resolution, minimum tailing factor and satisfactory retention time were found to be 5.745 min and 12.565 min for vitamin E acetate and ubidecarenone respectively. The method was linear in the range of 60-180 µg/ml for ubidecarenone and 20-60 µg/ml for vitamin E acetate with a correlation coefficient of 0.999 and 0.9993 respectively. Mean recoveries observed for ubidecarenone and vitamin E acetate were 99.85% and 99.73% respectively. The percentage relative standard deviation (% RSD) of peak area for system precision, method precision, and intermediate precision were found to be less than 0.37%. The lower degree of % RSD obtained has proved that the method was precise and robust.
Conclusion: A new simple HPLC method was developed and validated as per ICH guidelines for the simultaneous estimation of ubidecarenone and vitamin E acetate and the method can be effectively applied for the routine analysis of active pharmaceutical ingredient (API) and formulations.
SUPPLEMENTATION OF CALCIUM AND SELENIUM AGAINST CADMIUM INDUCED BIOACCUMULATION IN SELECTED TISSUES OF FRESH WATER FISH, OREOCHROMIS MOSSAMBICUS
Authors: Jamakala Obaiah 
Published: January 2019

Objective: Cadmium (Cd) is one of the most hazardous heavy metals in aquatic environments and could threaten aquatic organisms including fish. The present study was carried out to know the protective effects of calcium (Ca) and selenium (Se) in reducing the Cd bioaccumulation in selected tissues of fresh water fish, Oreochromis mossambicus.
Methods: The fresh water fish, Oreochromis mossambicus (Tilapia) was brought from the local ponds and were allowed for acclimatization to the laboratory conditions. After acclimatization, fish were exposed to sublethal concentration of Cd (1/10th of LC50/48h, i.e., 5 ppm) for 7, 15 and 30 d (d) period. 15d Cd-exposed fish were divided into three groups. The first group of fish were subjected to Ca (1 ppm) supplementation, second group received only Se (1 ppm) supplement and third group of fish were supplemented with the combination of both Ca and Se at the above said doses and observed for 7, 15 and 30d time periods. After specific time intervals, liver, kidney, gill and intestine tissues were isolated and used for Cd bioaccumulation studies.
Results: Cd concentration levels significantly (P<0.05) increased in the test tissues with increased period of exposure. Maximum Cd accumulation was found in 30d Cd-exposed fish kidney tissue (22.611±0.676 μg/gm wet wt. of the tissue). However, after supplementing with Ca and/or Se, there was a significant reversal in the levels of Cd concentration in all the test tissues. Maximum reduction was observed under Ca alone supplementation.
Conclusion: The present study clearly reveals that individual supplementation of Ca tends to detoxify the Cd body burden in the test tissues than the other modes of supplementation.
RECENT DEVELOPMENTS AND MULTIPLE BIOLOGICAL ACTIVITIES AVAILABLE WITH 1, 8-NAPHTHYRIDINE DERIVATIVES: A REVIEW
Authors: Gurjar Vinod Kumar , Pal Dilipkumar 
Published: January 2019

Within the wide range of nitrogen-containing heterocyclic compounds, the derivatives of 1,8-naphthyridine (NPTR) have gained a rising interest due to their reported versatile biological activities. The derivatives of NPTR scaffold are found to invite special interest from researchers nowadays on the significance of their manifestations of multiple attractive pharmacological activities which establish them as an effective and versatile tool in pharmaceutical chemistry and drug discovery. The diverse biological activities mainly include anti-inflammatory, antimicrobial, antiviral, anticancer, antihypertensive and analgesic activities. Novel NPTR scaffold has emerged its potency to treat neurological diseases like depression and Alzheimer's disease. Further these agents possess different inhibitory activities, such as anti-HIV, anti-osteoporotic, αvβ3 antagonism, antimalarial, platelet aggregation, anti-oxidant, anti-allergic, gastric antisecretory, anticonvulsant, epidermal growth factor receptor (EGFR) inhibition, protein kinase inhibition, ionotropic properties, β3 antagonism, phosphodiesterase 4 (PDE 4) inhibitions, adenosine receptor agonistic activity, adrenoceptors antagonism and DNA stabilizing activity, etc. In this review, we highlight the updates of different 1,8-naphthyridine derivatives and explain the key data available in the context of various biological activities of NPTR derivatives available from the literature. This may direct opportunity in researches in the synthesis of novel medicinal agents and the development of new heterocycles for modification of existing biological actions as well as evaluation of other possible pharmacological activities.
ANÁLISIS INTERTEMPORAL DEL MALTRATO INFANTIL EN COLOMBIA
Authors: Gallardo María 
Published: January 2019

El área de la pediatría social y salud pública se ocupa del niño y adolescente, sano y enfermo, en sus interrelaciones individuales y con la comunidad en el medio físico y humano en que se desarrolla. La presente investigación analiza el comportamiento del maltrato infantil en Colombia durante los años 2013 a 2018 con el fin de proponer modelos estadísticos que permitan explicarlo y realizar predicciones confiables de gran utilidad como fundamento a los planes de salud del estado. El trabajo se desarrolla a partir de las bases de datos del Instituto Nacional de Medicina Legal y Ciencias Forenses, del Observatorio del Bienestar de la Niñez del Instituto Colombiano de Bienestar Familiar y del Sistema Integral de Información, para las variables: violencia intrafamiliar, violencia interpersonal y delitos sexuales, desagregando por cohortes de edades de 0 a 4, 5 a 9, 10 a 14 y 15 a 17 años. Se estima en cada caso el modelo ARIMA correspondiente.
Uso de extratos naturais como inibidores de corrosão para o aço AISI 304
Authors: Da Silva Juliana Araujo , Sarpe Capo Graziella Sarpe Capo , Masaru de Souza Ribeiro Mauricio , Marques Pinto da Silva Mauricio 
Published: January 2019

O trabalho baseia-se em estudar o efeito de compostos não tóxicos ao meio ambiente e provenientes de recursos naturais renováveis, utilizando-os como inibidores de corrosão ambientalmente seguros para o aço AISI 304 em meio de HCl 0,1 mol/L. A avaliação da proteção à corrosão foi feita com a imersão de placas de aço em alíquotas dos extratos aquosos e etanólicos de erva mate e chá verde. O potencial de corrosão foi determinado utilizando eletrodo de calomelano saturado como referência. Na ausência de inibidores em um tempo de 60 minutos, o ensaio controle, apresentou potencial de corrosão (Ecorr) igual a -158 mV/ECS. Já em presença de extrato aquoso de erva mate, o Ecorr foi de - 138 mV/ECS e -149 mV/ECS para o extrato aquoso de chá verde. Os extratos etanólicos de erva mate e chá verde apresentaram valores de potencial de corrosão de -58 mV/ECS e -143 mV/ECS, respectivamente. Apenas o extrato etanólico da erva mate apresentou resultado significativo na inibição do processo corrosivo no metal em estudo, apresentando médias de Ecorr antes e após tratamento inibidor estatisticamente diferentes pelo teste t pareado. Assim, o extrato etanólico de erva mate apresenta potencial uso como inibidor verde de corrosão.
Produção de cerâmica vermelha utilizando argila proveniente da mineração de gipsita e resíduo de gesso
Authors: Cipriano Pamela Bento , Rezende Rafaela Tatianne Oliveira de , Ferraz Andréa De Vasconcelos 
Published: January 2019

Os resíduos de gesso e de argila são gerados ao longo da cadeia produtiva do gesso. O objetivo dessa pesquisa foi avaliar os efeitos da incorporação de resíduo de gesso da indústria de placas em argila residual obtida da extração da gipsita, para obtenção de produtos de cerâmica vermelha com melhores propriedades reduzindo os impactos ambientais. Foi avaliada a incorporação de 5% e 10% de resíduos de gesso na argila, considerando duas temperaturas de sinterização (800 e 1050 ºC), sendo determinada a retração linear, a absorção de água, a porosidade e a massa específica aparente, a perda ao fogo e a resistência à flexão. Avaliou-se a morfologia da superfície de fratura por microscopia. A resistência à flexão foi cerca de 4,24% e a absorção de água aproximadamente 11,45%. A formação de pequenos aglomerados e presença de poros foram evidenciadas pelas microscopias nas amostras contendo gesso independente do teor e das temperaturas de queima estudadas. Melhores resultados foram obtidos com a adição de 5% de resíduo de gesso queimadas a 800 ºC apresentando propriedades semelhantes à argila pura. A utilização de materiais residuais permite a redução dos impactos ambientais e a possibilidade de novas formulações para produtos de cerâmica vermelha.
O brinquedo como médium de comunicação e ludicidade das crianças
Authors: Lopes Maria da Conceição de Oliveira 
Published: January 2019

O presente artigo apresenta o brinquedo como forma de comunicação e expressão da ludicidade das crianças. Objetiva-se promover reflexão questionante sobre os modos de pensar este artefacto do mundo do artifício humano dirigido à ação de brincar, nomeadamente das crianças. Aludimos ao brinquedo, entendido pela criança, como a ação de brincar e ao brinquedo, concepção de adulto, resultante de um saber fazer material cuja natureza técnica se diferencia, desde a concepção ao processo de fabricação e finalização - o brinquedo artesanal e o brinquedo industrial racionalizado. Por fim, indicamos que há conteúdos inscritos nos brinquedos industrializados e que ficam expostos à influência das crianças, quando os utilizam. Como qualquer outro médium de comunicação o medium de comunicação-ludicidade que é o brinquedo industrial racionalizado têm a particularidade de influenciar e produzir efeitos nos modos como cada criança se pensa a si mesma, pensa o outro e o mundo onde convivem.
Estimation of Electrical Performance of a Polymer Insulator with Deposited Moss on the Surface under Impulse Voltage Condition in Foggy Weather
Authors: Abd Rahman Farah Asyikin , M Izadi , M.Z.A. Ab Kadir , J Jasni 
Published: January 2019

This paper presents a study about electric field behaviour of 10kV polymer insulator with moss deposition under foggy condition. The aim of this simulation experiment was to determine if this field affect the initiation of pollution flashover. To study this effect, simulations were carried out using High Frequency Structure Simulator (HFSS). The simulation experiment includes the results of electric field distribution along the insulator and also the magnitude of electric field at three different locations in identifying the parts of the insulator’s surface that likely to initiate pollution flashover. The moss deposited polymer insulator displayed uniformed and considerably intense distribution of electric field with the clean insulator. The field result showed the likelihood in discharging a corona effect. In short, the results indicated that electric field along the insulator surface would likely be influenced by moss deposition and foggy air.
Factors	Affecting	Low	Back	Pain	among	ICU	Nurses
Authors: Rochman Dadang , Mediani Henny Suzana , Nur’aeni Aan 
Published: January 2019

Low back pain is a pain syndrome that is often felt in the lower back region accompanied by spreading to the legs. It is often associated with work-related musculoskeletal disorders. This condition is often experienced by the Intensive Care Unit (ICU) nurses, from mild to severe LBP, which may affect the productivity of work and physic of the nurses. Aim to analyze and explore the factors that affected the number of low back pain incidents in ICU nurses in hospitals in the Banten Province. This study used the correlational analytic method with a crosssectional approach. The study sample was 82 ICU nurses, obtained by total sampling. Data collection used the LKQ questionnaire (Low back pain Knowledge Questions) and observation sheets. Data analysis used the Chisquare and multiple logistic regression analysis with a prediction model. Knowledge factor p (0.001), height p (0.021), night shift frequency p (0.003), and weight with a p-value (0.021) had a significant relationship with low back pain, whereas the ICU space environment factor p (0.668), work period p (0.462), and age p (0.079) did not have a significant relationship with low back pain. From related factors, knowledge had the most significant relationship with low back pain incident (OR = 38.62). This study has significantly proven that knowledge, height, weight, and frequency of night shifts affected the low back pain in ICU nurses. The nurse’s knowledge factor is the most influential factor of low back pain incident in ICU nurses. Increasing the ICU nurse’s knowledge about body biomechanics by following training and developing standard operating procedures. It is suggested to reduce the amount of excessive night shift burden ICU nurses, select and setting criteria for nurses working in the ICU.
Evaluation of Demographic Characteristics and Therapeutic Response to ocular Chemical Burn in Patients Referred to Eye Emergency Department of Farshchian Hospital in 2015-2016
Authors: Eslami Fateme , Bazzazi Nooshin , Seifrabiei Mohamad Ali , Hamidinekoo Maryam , Azizkhani Leila 
Published: January 2019

Objective:The chemical eye burn is one of the major emergencies in the ophthalmology that will result in irreparable complications in case of inappropriate and timely treatment in severe casesMaterial and Methods:In this cross-sectional study 250 patients with ocular chemical burn who referred to Farshchian Hospital were enrolled. Demographic characteristic and information regarding the burn were obtained. The Hughes-Roper-Hall classification was used for grading the severity of injury. All patients reevaluated 6 weeks later after injury.Results:Of 250 patients with complete follow up 155 cases ( 62% ) were male and 95 cases ( 38 % ) were female. Chemical injury were more common in the 20-40 years age group ( 108 case = 43/2 % ).The most common cause of chemical injury were occupational injury( 120 case = 48 % ).127 case (50/8 % ) of patients referred during The first hour after injury. The most common material of injury was acid in 102 cases (40/8 % ).Grade I burn was seen in 92 cases ( 36/8 % ) and grade IV in 30 cases ( 12 % ).Grading of the injury was related to the referring time after chemical burn. Severity of injury was more in alkaline burn.In 50 % of grade IV causes the burn had alkaline origin, however only 13/3 % of acid burn had grade IV severity. ( p : 0/001)Conclusion:The incidence of ocular chemical burn was approximately 2/19 % of all patients who referred to emergency ophthalmology service .According to this study ocular injury are more common in the men 20-40 years age group. The most common cause was occupational injury. Delay in referring and alkaline material were poor prognostic factor.
What is Emotional Pain? - A Review of Pathophysiology and Treatment Options
Authors: Zil-E-Ali Ahsan , Tariq Rooha , Pervaiz Nimra , Aadil Muhammad , Ali Asad , Ahmed Asma , Rahim khan Sara 
Published: January 2019

Pain is a dynamic process that involves multiple physiological systems for the perception and its outcomes. The basic pain process involves a complex neurological process. and biochemical changes. Emotional pain is an extended form of the already known pain where the stimuli are emotional of nature that involves abstract feelings, for example, losing a loved one. Like the pain, now there is a growing evidence that emotional pain also involves inflammatory process and the behavioral approach is directly linked with them. This association can help us modify the emotional pain by modulating the inflammatory processes that already known to us. Other than therapeutic and known interventions, mindfulness, writing therapy, exposure based intervention and other actions can help us in just not treating the condition but can serve as exploration of other avenues of the pain physiology. Emotional Pain has always been the part of human history but one of the least discussed form of pain. Multiple neuropsychiatric studies can help further in evaluation of this process.
Anion Recognition Via polarized –N-H Fragments
Authors: Kaloo Masood Ayoub 
Published: January 2019

Hydrogen bonding interaction and or proton transfer assets of synthetic molecules in presence of anionic species is pretty fascinating in the field of supramolecular analytical chemistry. Not only amide or urea based derivatives have appeared in the highlights, rather from last few decades, polarized free amine fragments (-NH2) have been brought under the study with prompt signaling. In this report, I will be focusing on the basic aspects which trigger free amine group to decode rapid anion recognition not only under organic media, but also under aqueous conditions in diverse environments.
Pengembangan E-Learning Berbasis Schoology pada Materi Impuls dan Momentum untuk Melatihkan Literasi Digital
Authors: Misbah Misbah , Pratama Wahyu Aji , Hartini Sri , Dewantara Dewi 
Published: January 2019

Penelitian dan pengembangan ini bertujuan untuk mendeskripsikan kelayakan media e-learning berbasis schoology. Tujuan penelitian secara khusus untuk mendeskripsikan: (1) validitas media, (2) kepraktisan media, dan (3) efektivitas media. Jenis penelitian ini adalah Research & Development (R&D) model ADDIE. Subjek uji coba penelitian ini adalah peserta didik kelas X MIPA 1 SMAN 6 Banjarmasin berjumlah 32 orang. Instrumen yang digunakan adalah lembar validasi media, lembar keterlaksanaan RPP, dan tes hasil belajar. Hasil penelitian menunjukkan: (1) validitas media diperoleh skor 3,94 berkategori valid, (2) kepraktisan media diperoleh skor 3,77 berkategori sangat praktis, dan (3) efektivitas media diperoleh skor 0,41 berkategori sedang. Simpulan penelitian ini adalah pengembangan e-learning berbasis schoology pada materi impuls dan momentum untuk melatihkan literasi digital layak digunakan pada pembelajaran.
Developing Teaching Material for Physics Based on Collaborative Creativity Learning (CCL) Model to Improve Scientific Creativity of Junior High School Students
Authors: Astutik Sri , Prahani Binar Kurnia 
Published: January 2019

The teaching material for Physics based on collaborative creativity learning (CCL) model is by design to improve scientific creativity, collaborative skills, and science process skills of junior high school students. The focus of this research is to analyze the teaching materials based on CCL model in terms of their validity (content and construct, reliable) and effectiveness to improve students’ scientific creativity in the science lesson, particularly for Physics education. The validity and effectiveness of the teaching material were measured by using Validation Assessment Sheet (VAS) and Scientific Creativity Assessment Sheet (SCAS). The data were analysed through mean validity score, Cronbach’s coefficient alpha, Wilcoxon test, N-gain, and Mann Whitney test. The results of this study include: (1) validity of the the CCL-based teaching materials for Physics fulfill validity criteria (valid and reliable); (2) in terms of components of validity, the CCL-based teaching materials for Physics: (a) there is an increase of students’ scientific creativity with the alpha of α = 0.05, (b) the average score of students’ scientific creativity was in medium category, and (c) there is no significant different improvement (consistent) of scientific creativity skills in all groups. The implication of this developmental research of CCL-based teaching materials for Physics has proven to be valid and effective to increase the scientific creativity of junior high school students, particularly in Motions and Simple Machine chapters.