bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Synthesis of Chondroitin Sulfate Proteoglycan Promotes Adult Hippocampal Neurogenesis in Response to Enriched Environment
Authors: Yamada Jun , Nadanaka Satomi , Kitagawa Hiroshi , Takeuchi Kosei , Jinno Shozo 
Published: August 2018

Chondroitin sulfate proteoglycan (CSPG) is a candidate regulator of embryonic neurogenesis. The aim of this study was to specify the functional significance of CSPG in adult hippocampal neurogenesis using male mice. Here, we showed that neural stem cells and neuronal progenitors in the dentate gyrus were covered in part by CSPG. Pharmacological depletion of CSPG in the dentate gyrus reduced the densities of neuronal progenitors and newborn granule cells. 3D reconstruction of newborn granule cells showed that their maturation was inhibited by CSPG digestion. The novel object recognition test revealed that CSPG digestion caused cognitive memory impairment. Western blot analysis showed that expression of β-catenin in the dentate gyrus was decreased by CSPG digestion. The amount of CSPG in the dentate gyrus was increased by enriched environment (EE) and was decreased by forced swim stress. In addition, EE accelerated the recovery of CSPG expression in the dentate gyrus from the pharmacological depletion and promoted the restoration of granule cell production. Conversely, the densities of newborn granule cells were also decreased in mice that lacked chondroitin sulfateN-acetylgalactosaminyltransferase 1 (CSGalNAcT1), a key enzyme for CSPG synthesis (T1KO mice). The capacity of EE to promote granule cell production and improve cognitive memory was impaired in T1KO mice. These findings indicate that CSPG is involved in the regulation of adult hippocampal neurogenesis and suggest that increased synthesis of CSPG by CSGalNacT1 may mediate promotion of granule cell production and improvement of cognitive memory in response to EE.SIGNIFICANCE STATEMENTChondroitin sulfate proteoglycan (CSPG) is a candidate regulator of embryonic neurogenesis. Here, we specified the role of CSPG in adult neurogenesis in the mouse hippocampus. Digestion of CSPG in the dentate gyrus impaired granule cell production and cognitive memory. Enriched environment (EE) promoted the recovery of CSPG expression and granule cell production from the CSPG digestion. Additionally, adult neurogenesis was impaired in mice that lacked a key enzyme for CSPG synthesis (T1KO mice). The capacity of EE to promote granule cell production and cognitive memory was impaired in T1KO mice. Altogether, these findings indicate that CSPG underlies adult hippocampal neurogenesis and suggest that increased synthesis of CSPG may mediate promotion of granule cell production in response to EE.
Vyresnio amžiaus asmenų persikėlimo į socialinės globos įstaigą patirtis: literatūros apžvalga
Authors: Charenkova Jūratė 
Published: August 2018

[only abstract and keywords in English; full article, abstract and keywords in Lithuanian]
Relocation to residential care facility in older age is considered as one of the most significant life transitions, that causes great deal of stress, depression and anxiety to the elderly. It is said, that transition to residential care facility is only slightly less stressful event than divorce or death of a spouse. After relocation older people are faced with a lot of unknowns in form of new people, new physical surroundings and new social demands. Relocation to residential care facility is a challenge for usual lifestyle: changes in one’s social network, loss of autonomy, reduced opportunities of maintaining favorite activities, adapting to new social and physical environment, attempts to create new home in residential care facility demand a lot of adaptive efforts from the elderly. These are the most common challenges to identity and well-being of the elderly. On other hand, relocation to residential care facility not only creates new challenges for elderly people, but also creates a new opportunities in form of new friends, new activities and sense of security since in case of emergency there are always staff close by. So there are possibilities of reconstructing one’s identity and maintaining well-being.
Kochlearinė implantacija Lietuvoje: paplitimas ir sistemos apžvalga
Authors: Mataitytė - Diržienė Jurga , Stumbrys Daumantas , Byčkova Jekaterina , Lesinskas Eugenijus 
Published: August 2018

[straipsnis, santrauka, reikšminiai žodžiai lietuvių kalba; santrauka ir reikšminiai žodžiai anglų kalba]
Anksčiau atliktų tyrimų rezultatai rodo, kad kochlearinė (klausos) implantacija kartu su nuosekliai įgyvendinama klausos lavinimo programa gali užtikrinti sėkmingą kurčių vaikų socialinę integraciją. Kochlearinė implantacija Lietuvoje atliekama nuo 1998 metų. Iki 2017 metų pabaigos šalyje implantuoti 377 asmenys, dauguma iš jų – vaikai. Daugelis šios srities tyrimų yra skirta klinikiniams ar technologiniams kochlearinės implantacijos aspektams nagrinėti, tačiau trūksta darbų, kuriuose būtų nagrinėjami sveikatos politikos ir socialinės integracijos klausimai. Straipsnyje apžvelgiama dabartinė kochlearinės implantacijos sistema, implantacijų paplitimas ir paciento kelias. Tyrime derinami teisės aktų bei kitų dokumentų analizės ir aprašomosios statistikos metodai. Straipsnio autorių žiniomis, tai pirmas tyrimas, skirtas kochlearinės implantacijos sistemos apžvalgai Lietuvoje.
Resolusi Affirmative Action di Pengadilan
Authors: Indah Furba 
Published: August 2018

Kasus kekerasan seksual yang terdapat pada catatan tahunan Komisi Nasional Perempuan tahun 2016 mengatakan secara jelas yang terungkap dalam angka-angka mencapai puncaknya 259.150 kasus kekerasan yang terjadi terhadap perempuan. Penegakan hukum yang sudah banyak dicanangkan dan ditetapkan dalam bentuk materil untuk setiap kasus kekerasan terhadap perempuan seperti yang tertuang dalam UU no 23 tahun 2004 tentang Perlindungan Korban Kekerasan Dalam Rumah Tangga (KDRT) sejatinya telah memberikan prinsip dasar perlindungan korban kekerasan dalam lingkup rumah tangga. Bahwa undang-undang tersebut dirasa sebagai terobosan baru dalam wacana perlindungan kekerasan terhadap perempuan yang juga sejalan dengan Konvensi Penghapusan Segala Bentuk Diskriminasi terhadap Perempuan (CEDAW) melalui Undang-Undang Nomor 7 Tahun 1984 pada tanggal 24 Juli 1984. DOI: 10.15408/adalah.v1i1.8202
Pengadilan Jalanan Versus Negara Hukum
Authors: Romlah Siti 
Published: August 2018

Beberapa waktu lalu, banyak media massa yang memberitakan tentang terjadinya perbuatan main hakim sendiri yang berujung pada tewasnya seseorang yang dituduh menjadi pelaku pencurian karena dibakar oleh amarah massa. Tentunya berita itu sempat menggegerkan masyarakat di seluruh penjuru Indonesia. Namun, kejadian main hakim sendiri atau yang biasa disebut dengan “pengadilan jalanan” hingga memakan korban jiwa, bukanlah hal baru di Indonesia. Seperti yang diungkapkan oleh sosiolog terkenal Sigit Rochadi kepada e-buletin Okezone.com (8/8/2017) yang menyatakan bahwa pada tahun 2015 setidaknya terdapat 7.766 kasus kekerasan yang diantaranya adalah 60,8% main hakim sendiri dan dari angka tersebut terdapat setidaknya 6,8% yang berujung dengan tewasnya tersangka.
Model Diversifikasi Sistem Perwakilan Rakyat
Authors: Yunus Nur Rohim 
Published: August 2018

Keberadaan partai politik di negara demokrasi sangat dibenarkan. Ia dijadikan sebagai pilar demokrasi dan pelaksana kedaulatan rakyat. Substansi pokok partai politik berupa kedaulatan (status) dan peranan (role) merupakan hal penting dalam perjalanan sistem demokrasi. Hal tersebut disebabkan karena keduanya memainkan peran penghubung antara pemerintah negara dengan warga negaranya.
Adoption of Serogroup B Meningococcal Vaccine Recommendations
Authors: Kempe Allison , Allison Mandy A. , MacNeil Jessica R. , O’Leary Sean T. , Crane Lori A. , Beaty Brenda L. , Hurley Laura P. , Brtnikova Michaela , Lindley Megan C. , Albert Alison P. 
Published: August 2018

BACKGROUND AND OBJECTIVES:
In 2015, the Advisory Committee on Immunization Practices recommended that 16- to 23-year-olds may be vaccinated with the serogroup B meningococcal (MenB) vaccine on the basis of individual clinical decision-making (Category B). We assessed the following among US pediatricians and family physicians (FPs): (1) practices regarding MenB vaccine delivery, (2) factors influencing a decision to recommend the MenB vaccine, and (3) factors associated with discussing the MenB vaccine.

METHODS:
We surveyed a nationally representative sample of pediatricians and FPs via e-mail and Internet from October 2016 to December 2016.

RESULTS:
The response rate was 72% (660 of 916). During routine visits, 51% of pediatricians and 31% of FPs reported always or often discussing MenB vaccine. Among those who discussed often or always, 91% recommended vaccination; among those who never or rarely discussed, 11% recommended. We found that 73% of pediatricians and 41% of FPs currently administered the MenB vaccine. Although many providers reported not knowing about factors influencing recommendation decisions, MenB disease outbreaks (89%), disease incidence (62%), and effectiveness (52%), safety (48%), and duration of protection of MenB vaccine (39%) increased the likelihood of recommendation, whereas the Category B recommendation (45%) decreased likelihood. Those somewhat or not at all aware of the MenB vaccine (risk ratio 0.32 [95% confidence interval 0.25–0.41]) and those practicing in a health maintenance organization (0.39 [0.18–0.87]) were less likely, whereas those aware of disease outbreaks in their state (1.25 [1.08–1.45]) were more likely to discuss MenB vaccine.

CONCLUSIONS:
Primary care physicians have significant gaps in knowledge about MenB disease and the MenB vaccine, and this appears to be a major driver of the decision not to discuss the vaccines.
Optimization of microclonal propagation in vitro of oregano (Origanum vulgare)
Authors: Fokina A. V. , Satarova T. M. , Smetanin V. T. , Kucenko N. I. 
Published: August 2018

Medicinal plants are important objects for botany, systematics and plant geography research, as well as physiology, pharmacology, and biotechnology. Medicinal plants from the Lamiaceae family are being intensively studied for medical and pharmacological reasons. This family also includes the medicinal herbaceous plant oregano (Origanum vulgare L.), known from ancient times for its antimicrobial and antifungal properties, the ability to strengthen the human immune system, and to improve the general state of an organism. At present, the study of its antimicrobial, antifungal, insecticidal, anticoagulant, antitumor, therapeutic and many other properties is being actively continued. Due to the relevance of the development of the principles of O. vulgare micropropagation in vitro and the undeveloped conditions and methods of its cultivation, the aim of this work was to optimize microclonation in vitro of oregano via the activation of auxiliary buds. The research tasks were to test the ability of auxiliary buds to be activated depending on the localization on the donor shoot internodes and to intensify the root formation of cuttings through medium content optimization. The influence of the location of the auxiliary buds on donor shoots on their activation in vitro was studied on such indicators as the length of newly formed shoots, the number of nodules per one newly formed shoot, and the number of newly formed shoots per one bud. In plant microclonal propagation, the stage of root formation is very important for further adaptation in soil. Practical experience has shown that for the effective adaptation of oregano in soil, the length of the root system for cuttings should be 1.5–2.0 cm, the degree of root system development – 4–5 points under shoot length of 3–5 cm. The study of peculiarities of oregano microclonal propagation via activation of auxiliary buds has allowed us to optimize the stage of explant selection for cutting and the formation of cuttings’ roots. It has been established that for optimal length, the number of nodules of the newly formed shoots and the number of newly formed shoots, the first internode, located on the top of a parent shoot, as well as the third to fifth ones are more suitable. For rooting oregano cuttings, the optimal medium on the ratio of length and density of root system and on shoot length is the nutrient one containing half of the macro-, microsalts and vitamins on Murashige-Skoog, 20 g/l sucrose and 0.75 mg/l kinetin.
Agroecological and agroeconomic aspects of the grain and grain legumes (pulses) yield dynamic within the Dnipropetrovsk region (period 1966–2016)
Authors: Zhukov O. V. , Pelina T. O. , Demchuk O. M. , Demchuk N. I. , Koberniuk S. O. 
Published: August 2018

This paper reveals the spatial and temporal patterns of grain and leguminous crops yield dynamics in Dnipropetrovsk region and evaluates the role of agro-environmental and agro-economic factors in their formation. Crop data were obtained from the State Statistics Service of Ukraine. The data of the grain and grain legumes (pulses) yield during 1966–2016 on average per year in the administrative districts of Dnipropetrovsk region was analysed. The obtained data indicate that average yields of cereals and leguminous crops within Dnipropetrovsk region varies from 24.3 to 33.4 CWT/ha. The smallest interannual variability in yield is typical for Vasylkivskyi district (CV = 9.9%), and the largest is typical for Yurivskyi district (CV = 27.7%). As a result of the principal component analysis of the cereals and leguminous crops yields variability, three principal components were extracted which together explain 81.2% of the overall yield variability. Principal component 1 explains 69.4% of the total variability. It indicates the total synchronous yields variation within the area investigated as all examined variables have high loading values on principal component 1. The administrative districts that form a belt located in the direction from the north east to the south west of the region have the most coordinated variance, which is reflected by principal component 1. Principal component 2 explains 6.8% of the yield variability. This principal component is sensitive to opposite yield dynamics of central and south-western districts on the one hand and the eastern and northern districts – on the other. Principal component 3 explains 4.9% of the yield variability. This principal component reveals the opposite dynamics of productivity of the central districts on the one hand and the northern and south-eastern districts on the other. The cluster analysis of administrative districts was conducted based on the dynamics of the yield of grain and leguminous as a result of which four clusters were identified. The clusters are geographically defined administrative districts, together forming spatially connected areas. The similar temporal yield dynamics of grain and leguminous crops as a result of interaction between endogenous and exogenous ecological factors is the main principle for revealling such ecologically homogeneous territories. Spatial distribution of principal components indicates a continual pattern, but their overlapping allows one to extract spatially discrete units, which we identified as agroecological zones. Each zone is characterized by a certain character and dynamics of production capacity and has an invariant pattern of response to varying climatic, environmental, and agroeconomic factors.
Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib
Authors: Serrano César , García-del-Muro Xavier , Valverde Claudia , Sebio Ana , Durán José , Manzano Aránzazu , Pajares Isabel , Hindi Nadia , Landolfi Stefania , Jiménez Laura , Rubió-Casadevall Jordi , Estival Anna , Lavernia Javier , Safont María José , Pericay Carles , Díaz-Beveridge Roberto , Martínez-Marín Virginia , Vicente-Baz David , Vivancos Ana , Hernández-Losa Javier , Arribas Joaquín , Carles Joan 
Published: August 2018

Abstract

Background
Oncogenic KIT/PDGFRA signaling inhibition with imatinib achieves disease control in most patients with advanced/metastatic gastrointestinal stromal tumor (GIST), but resistance eventually develops after 20–24 months. Notably, a small subset of these patients obtain durable benefit from imatinib therapy.

Methods
We analyzed clinical, pathological, and molecular characteristics and long-term outcomes in patients with metastatic GIST treated with continuous daily dosing of frontline imatinib in a cohort of patients benefiting for ≥5 years. A control group was obtained from the national Spanish Group for Sarcoma Research database and used as comparator.

Results
Sixty-four imatinib long-term responders (LTRs) and 70 control cases were identified. Compared with controls, LTRs at baseline had better performance status (PS) 0–1 (100% vs. 81%), lower mitotic count (median, 8 vs. 15), and tumor burden (number of metastases, 3 vs. 7). KIT exon 11 was the only region found mutated in LTRs. LTRs achieved 34% complete responses and a median progression-free survival of 11 years, compared with 4% and 2 years, respectively, in the control cohort. Prognostic factors that independently predicted long-term benefit with imatinib were PS, number of metastases prior to imatinib, and response to imatinib. Fifteen LTR patients developed new side effects attributable to imatinib after ≥5 years of continuous treatment. No resistance mutations were found in metastatic samples from three patients progressing on imatinib.

Conclusion
GISTs in LTRs are a distinctive entity with less aggressive behavior and marked sensitivity to KIT inhibition. Patients reaching 5 or more years on imatinib have a higher chance of remaining progression free over time.
CONHECIMENTO DE TÉCNICOS E AUXILIARES DE ENFERMAGEM SOBRE CUIDADOS COM CATETERES CENTRAIS EM UM HOSPITAL PEDIÁTRICO
Authors: Rodrigues Rocha Jessika , Ollé Mendes da Silva Juliana , Da Costa Milena , Vargas Makuch Débora Maria 
Published: August 2018

<p>Objetivo: identificar os conhecimentos de técnicos e auxiliares de enfermagem acerca dos cuidados com a manutenção de cateteres venosos centrais de longa, média e curta permanência em crianças. Método: estudo exploratório-descritivo com abordagem quantitativa, realizado de setembro a novembro de 2017, com amostra de 157 técnicos e auxiliares de enfermagem das unidades de internação de uma instituição exclusivamente pediátrica do estado do Paraná, Brasil. Resultados: responderam que já haviam recebido orientações sobre cuidados de enfermagem com cateteres centrais 134 (85,3%) participantes, entretanto 92 (58%) colaboradores pontuaram que a seringa de 1 ml não deve ser utilizada no manuseio desses dispositivos, evidenciando que ainda ocorriam erros nos apontamentos quanto aos cuidados adequados com esses acessos. Conclusão: apesar de a equipe de enfermagem conhecer os cuidados com a manutenção de cateteres centrais, percebeu-se que ainda existiam dificuldades quanto aos cuidados primordiais com esses dispositivos intravenosos de grande relevância para a eficácia da terapia medicamentosa em pediatria. </p><p>Descritores: Cuidados de enfermagem. Cateterismo venoso central. Administração intravenosa. Educação continuada.</p>
O CENÁRIO DA FORMAÇÃO SUPERIOR EM GASTRONOMIA NO BRASIL
Authors: CABRAL Silvia Regina , ANJOS Francisco Antônio dos , HOSTINS Regina Celia Linhares 
Published: August 2018

Resumo:A expansão da formação profissional na área de gastronomia no país é uma realidade. Este artigo apresentará a oferta existente de cursos superiores na área, suas modalidades, o grau e respectivas localizações geográficas, na última década. Utilizou-se a pesquisa de caráter exploratório, de base documental, cujas fontes foram o Portal e-Mec do Ministério da Educação, de acesso público, e as páginas on line dos cursos. Após este levantamento, elaborou-se uma ficha para a validação das informações com os gestores e\ou coordenadores dos respectivos cursos. Como resultado, obteve-se 187 cursos cadastrados, sendo confirmadas as informações de 138 cursos, caracterizando-se o primeiro filtro. Buscou-se, no período de vestibular e outros processos seletivos\2016, nas páginas on lines, identificar a oferta ou não destes, caracterizando-se como segundo filtro. Identificou-se que 151 cursos foram ofertados em 2016, sendo na modalidade presencial, 128 cursos em tecnologia, 09 cursos de bacharelado e na modalidade à distância, 14 cursos de tecnologia, com predominância de oferta na iniciativa privada, com ou sem fins lucrativos. A distribuição geográfica destes dar-se nas regiões norte, centro-oeste, sul, região sudeste e na região nordeste, prevalecendo a oferta no grau em tecnologia no estado de São Paulo e no grau de bacharelado em Santa Catarina.
The Effect of Economic Variables in the Exchange Rate of the Iraqi Dinar for the Period (1995-2015)
Authors: Qasim Muslim 
Published: August 2018

This study aims to identify the trends of fluctuations of Iraqi dinar exchange rate along with diagnosis the factors that influencing it. The importance of this study is that it attempts to examine the mechanisms of impacts some economic variables on the exchange rate fluctuations of Iraqi economy as a result of the use of the Iraqi Central Bank's policies. This study based on a hypothesis that states: Iraqi dinar exchange influenced by several factors and variables, some are fact and some are because the hard cash that led to the occurrence of fluctuations. Since the cash supply has a positive as well as a significant impact on creating and finding these fluctuations. This study comprises three sections: first section presenting the theoretical framework of the exchange rate. Second section focuses on the Relationship of the exchange rate of the Iraqi dinar with economic variables. Finally, the third section analyzes the results of impacts some economic variables on the Iraqi dinar fluctuations exchange rate for the period of (1995-2015). The study found a set of results, and based on the outcomes of the study a number of recommendations has been presented.
México: ¿un modelo para países en desarrollo?
Authors: Tanski Janet , Blum Albert 
Published: August 2018

La investigación sobre el Tratado de Libre Comercio de Norteamérica (TLCN) ha descuidado la importancia que tienen la concentración de capital en México y el efecto que el libre comercio habrá de ejercerse en los conglomerados de este país. El objetivo de este documento es analizar la situación económica de México después del arribo de las políticas de estabilización y observar la forma en que se han visto afectados los diferentes sectores industriales y de la población, toda vez que se ha sugerido a México como un modelo, tanto de estabilización exitosa como de ajuste estructural y de liberalización del comercio, para aquellos países en proceso de desarrollo que se encuentran altamente endeudados.
Erzurum İli Süt Sığırcılığı İşletmelerinin Sermaye Yapısına Dayalı Risk Düzeyleri
Authors: Topcu Yavuz 
Published: August 2018

Bu çalışmanın amacı,
Erzurum ili süt sığırcılığı işletmelerinin 2013-2014 cari dönem verilerine
dayalı bilanço tablolarının oluşturularak, işletmelerin sermaye yapısına dayalı
risk düzeylerini belirlemektir. Bu amaç
için Oltu, Narman, Pasinler ve Çat ilçelerinde 145 süt sığırcılığı işletmesi
ile yürütülen anketlerden elde edilen birincil veriler, araştırmanın ana
materyalini oluşturmuştur. İşletmelerin 2013-2014 üretim periyodu için bilanço
tablosu hazırlanmış ve başlıca finansal oranlar hesaplanmıştır. Araştırma
sonuçları; bütün süt sığırcılığı işletmeleri cari dönen aktifler ile likidite
açısından riskli konumda olduğunu, işletmecilerin faaliyet dönemi
yükümlülüklerini yerine getirebilecek finansal güce sahip olmadıklarını, net
sabit aktifler yönünden aşırı aktif varlıklara sahip olduklarını ve bütün
bunların da maliyetleri artırdığını göstermiştir. Diğer taraftan, bütün
işletmelerde sermaye devir oranın düşüklüğünden dolayı, finansal ve ekonomik
rantabilite oranları düşük düzeylerde kalmaktadır. İşletmelerin cari
varlıklarının sabit aktifler aleyhine belirli bir denge düzeyine
getirilebilmesi durumunda, faaliyet başarı oranları artırılabilir ve böylece
işletmelerin sürdürülebilirliği önemli ölçüde garanti altına alınabilir.