bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tenant Right-to-Counsel and Adverse Birth Outcomes in New York, New York
Authors: Leifheit Kathryn M. , Chen Katherine L. , Anderson Nathaniel W. , Yama Cecile , Sriram Achyuth , Pollack Craig Evan , Gemmill Alison , Zimmerman Frederick J. 
Published: October 2024

ImportanceIn 2017, New York, New York, launched the United States’ first right-to-counsel program, guaranteeing lawyers to low-income tenants in select zip codes, which was associated with reducing eviction risk by half. Given documented associations between evictions during pregnancy and adverse birth outcomes, the right-to-counsel program may be associated with improved birth outcomes.ObjectiveTo measure associations between zip code–level right-to-counsel access and risk of adverse birth outcomes, including preterm birth and low birth weight, among infants born to Medicaid-insured birthing parents.Design, Setting, and ParticipantsThis retrospective cohort study leveraged the staggered rollout of New York’s right-to-counsel program from January 2016 to February 2020 as a natural experiment using a population-based sample of live births to Medicaid-insured birthing parents residing in New York, New York. Data were analyzed from February 2022 to September 2024.ExposureZip code right-to-counsel status 9 months prior to birth.Main Outcomes and MeasuresAdverse birth outcomes were measured using individual birth records from the New York Bureau of Vital Statistics. Outcomes included dichotomous indicators of low birth weight (&amp;lt;2500 g), preterm birth (&amp;lt;37 weeks’ gestation), and a composite of both. Difference-in-differences linear probability models controlled for year, month, and zip code and included clustered standard errors.ResultsAmong 260 493 live births (mean [SD] birthing parent age, 29 [6] years) from January 2016 to February 2020, 43 081 births (17%) were to birthing parents residing in zip codes where right-to-counsel was available during pregnancy. Exposure to right-to-counsel during pregnancy was associated with statistically significant reductions in infants’ probability of adverse birth outcomes, with reductions of 0.73 (95% CI, 0.06-1.41) percentage points in low birth weight, 0.91 (95% CI, 0.10-1.71) percentage points in preterm birth, and 0.96 (95% CI, 0.09-1.84) percentage points in the composite outcome in treated vs untreated zip codes.Conclusions and RelevanceThis cohort study found that right-to-counsel was associated with reduced risk of adverse birth outcomes among Medicaid-insured birthing parents. These findings suggest that eviction prevention via right-to-counsel may have benefits that extend beyond the courtroom and across the life-course.
Breast cancer survival prediction using an automated mitosis detection pipeline
Authors: Stathonikos Nikolas , Aubreville Marc , de Vries Sjoerd , Wilm Frauke , Bertram Christof A , Veta Mitko , van Diest Paul J 
Published: October 2024

AbstractMitotic count (MC) is the most common measure to assess tumor proliferation in breast cancer patients and is highly predictive of patient outcomes. It is, however, subject to inter‐ and intraobserver variation and reproducibility challenges that may hamper its clinical utility. In past studies, artificial intelligence (AI)‐supported MC has been shown to correlate well with traditional MC on glass slides. Considering the potential of AI to improve reproducibility of MC between pathologists, we undertook the next validation step by evaluating the prognostic value of a fully automatic method to detect and count mitoses on whole slide images using a deep learning model. The model was developed in the context of the Mitosis Domain Generalization Challenge 2021 (MIDOG21) grand challenge and was expanded by a novel automatic area selector method to find the optimal mitotic hotspot and calculate the MC per 2 mm2. We employed this method on a breast cancer cohort with long‐term follow‐up from the University Medical Centre Utrecht (N = 912) and compared predictive values for overall survival of AI‐based MC and light‐microscopic MC, previously assessed during routine diagnostics. The MIDOG21 model was prognostically comparable to the original MC from the pathology report in uni‐ and multivariate survival analysis. In conclusion, a fully automated MC AI algorithm was validated in a large cohort of breast cancer with regard to retained prognostic value compared with traditional light‐microscopic MC.
Building the OAChangeMap to Improve the Service Delivery of the New South Wales Osteoarthritis Chronic Care Program: A Worked Example of Using a Codesign Framework
Authors: Eyles Jillian P. , Kobayashi Sarah , Duong Vicky , Hunter David J. , Avdalis Christos , Buttel Tom , Dawson Greer , Dório Murillo , D'Souza Nicole , Foster Kirsty , Maka Katherine , March Marie K. , Menz Fred , Pratt Carin , Rankin Nicole M. , Richardson Daniel , Thompson Julia , Strong Charlotte , Bowden Jocelyn L. 
Published: October 2024

ObjectiveThe Osteoarthritis Chronic Care Program (OACCP) has been implemented in Australian public hospitals to deliver best evidence osteoarthritis (OA) care. It is important to ensure that the OACCP continues to deliver evidence‐based OA care as intended. We aimed to identify barriers and enablers to delivering the OACCP, prioritize the barriers, and generate strategies to address them.MethodsThis study provides a worked example of a seven‐step theory‐informed codesign framework. We invited OACCP coordinators to participate in semistructured interviews (analyzed thematically) and complete a questionnaire to identify barriers and enablers to delivery of the OACCP. We then invited a broader group of stakeholders (OACCP coordinators, health managers, policy makers, consumers, and researchers) to prioritize the barriers via a short survey (survey 2). We held five codesign workshops in which we mapped the priority barriers to the Theoretical Domains Framework and developed strategies to address them.ResultsSixteen coordinators were interviewed, and the main barriers identified were as follows: (1) patients often have beliefs that are inconsistent with best evidence care, (2) there are aspects of clinical care that are not delivered optimally, and (3) system‐level factors are a barrier to optimal patient care and sustainability of the OACCP. We codesigned a plan for action with patient educational materials, shared decision‐making tools, and health professional education and training.ConclusionOur worked example of codesign used a theory‐based, data‐driven approach with key stakeholders, identified and prioritized barriers to the delivery of the OACCP, acknowledged enablers, and generated a plan for feasible strategies to improve the program.
Comparing Rituximab and Cyclophosphamide in Induction Therapy for Childhood‐Onset Anti‐Neutrophil Cytoplasmic Antibody‐Associated Vasculitis: An ARChiVe Registry Cohort Study
Authors: Gagne Samuel J. , Sivaraman Vidya , Bosman Else S. , Klamer Brett , Morishita Kimberly A. , Huber Adam , Orjuela Alvaro , Eberhard Barbara , Myrup Charlotte , Gerstbacher Dana , Foell Dirk , Al‐Abadi Eslam , McErlane Flora , Cook Kathryn , Wagner‐Weiner Linda , Elder Melissa , Moorthy L. Nandini , Dancey Paul , Yeung Rae , Khubchandani Raju , Deepak Samundeeswari , Charuvanij Sirirat , Tarvin Stacey , Shenoi Susan , Tanner Tamara , Brown Kelly , Cabral David A. ,   for the ARChiVe Investigators Network within the PedVas Initiative
Published: October 2024

ObjectiveGranulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are chronic life‐threatening vasculitides requiring substantial immunotherapy. Adult trials identified rituximab (RTX) as an alternative to cyclophosphamide (CYC) for remission induction of GPA and MPA. Disease rarity has limited feasibility of similar trials with pediatric patients. We aim to evaluate the relative efficacy and toxicity of CYC and RTX for patients with childhood GPA and MPA through registry‐based comparative evaluation.MethodsFrom A Registry of Childhood Vasculitis, we identified patients with GPA and MPA who received induction with RTX or CYC. Pediatric Vasculitis Activity Score (PVAS) and Pediatric Vasculitis Damage Index (pVDI) score evaluated disease activity and damage. Descriptive statistics summarized patient characteristics. RTX and CYC comparisons used logistic regression for primary outcomes of postinduction remission (PVAS = 0) or low disease activity (PVAS ≤ 2). Hospital admission for adverse events and pVDI scores were compared using logistic regression and ordinal regression, respectively.ResultsAmong 104 patients, 43% received RTX, 46% CYC, 11% both. Treatment groups did not significantly differ for diagnosis PVAS and onset age. There was no difference in remission among the groups (63% overall; odds ratio [OR] 1.07, 95% confidence interval [CI] 0.45–2.52). Hospitalizations occurred in 22% of patients receiving RTX versus 10% patients receiving CYC (OR 2.27, 95% CI 0.73–7.05). The median 12‐month pVDI score was 1 in both groups (OR 0.98, 95% CI 0.43–2.22).ConclusionThis is the first study comparing CYC and RTX for induction in pediatric GPA and MPA. No significant differences were shown in rates of remission, severe adverse events, or organ damage. Limitations included lack of standardized treatment regimens, retrospectivity, and lack of longitudinal adverse drug‐related event data.
Bifunctional Ion Rectification Layer Separators Toward Superior Reversible Dendrite‐Free Zinc Metal Anodes
Authors: Yao Jia , Li Jingying , Chen Chi , Ge Luyang , Wan Qian , Yang Yin , Gan Yi , Lv Lin , Tao Li , Wang Hanbin , Zhang Jun , Wan Houzhao , Wang Hao 
Published: October 2024

AbstractThe slow transport dynamics and poor dendritic growth significantly hinder the performance of zinc metal batteries. Here, a unique difunctional ion rectification strategy is developed using vacuum evaporation technology to design a coated separator for efficient ion transport. The highly conductive Cu‐coated separator acts as an ion redistributor, ensuring homogenized electric field distribution. The excellent znophilicity of the copper coating acts as an ion accelerator, promoting ion transport and facilitating face‐to‐face zinc deposition on the separator. Consequently, this synergy enables stable battery operation at high current densities (cumulative capacity up to 10 800 mAh cm−2 at 8 mA cm−2) and high depth of discharge (over 200 h at 94% DOD). The Cu‐coated separator exhibits a reversible plating/stripping life of over 2400 h with an average coulombic efficiency of 99.88%. Notably, the Cu‐coated separator significantly enhances the rate performance and cycle capacity of Zn||V6O13 and Zn||MnO2 full cells. This functional separator with a difunctional ion rectification strategy presents a promising solution to the challenge of zinc metal anodes.
Molecule‐level Design to Form Pocket Structures for Improving Amine Efficiency in CO2 Capture
Authors: Shi Haitao , Cao Rong , Zhang Haijun , Yang Jiajia , Fu Yanlin , Chen Jiping 
Published: October 2024

AbstractSolid amine adsorbents represent a promising class of CO2 sorbents, but their amine efficiency is limited by the inaccessibility of peripheral amines. The surface of mesocellular silica foam (MCF) is functionalized with the mixture of short‐chain 3‐Glycidyloxypropyl) triethoxysilane (GPTES) and long‐chain Octadecyltrimethoxysilane (OTMS), forming pocket structures on the support surface, thereby exposing more amine sites and enhancing the amine efficiency of polyethylenimine (PEI). The resulting adsorbent demonstrates a high CO2 adsorption capacity (5.02 mmol g−1 at 50 °C, 10 vol.% CO2, and 50%RH), high amine efficiency (0.43 at the dry condition), outstanding cyclic stability (0.5% performance decline per cycle under the conditions of dry CO2 regeneration), and fast adsorption kinetics (15 min for adsorption saturation at 50 °C). First‐principles calculations and CO2 temperature‐programmed desorption (TPD) experiments demonstrate that the introduction of GPTES and OTMS is beneficial to decreasing adsorption energy and forming paired carbamic acid states and ammonium carbamate states.
CircFndc3b Mediates Exercise‐Induced Neuroprotection by Mitigating Microglial/Macrophage Pyroptosis via the ENO1/KLF2 Axis in Stroke Mice
Authors: Zhao Yun , He Xiaofei , Yang Xiaofeng , Hong Zhongqiu , Xu Yin , Xu Jinghui , Zheng Haiqing , Zhang Liying , Zuo Zejie , Hu Xiquan 
Published: October 2024

AbstractCircular RNA (circRNA) plays a pivotal role in regulating neurological damage post‐ischemic stroke. Previous researches demonstrated that exercise mitigates neurological dysfunction after ischemic stroke, yet the specific contributions of circRNAs to exercise‐induced neuroprotection remain unclear. This study reveals that mmu_circ_0001113 (circFndc3b) is markedly downregulated in the penumbral cortex of a mouse model subjected to middle cerebral artery occlusion (MCAO). However, exercise increased circFndc3b expression in microglia/macrophages, alleviating pyroptosis, reducing infarct volume, and enhancing neurological recovery in MCAO mice. Mechanistically, circFndc3b interacted with Enolase 1 (ENO1), facilitating ENO1's binding to the 3' Untranslated Region (3'UTR) of Krüppel‐like Factor 2 (Klf2) mRNA, thereby stabilizing Klf2 mRNA and increasing its protein expression, which suppressed NOD‐like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome‐mediated microglial/macrophage pyroptosis. Additionally, circFndc3b enhanced ENO1's interaction with the 3′UTR of Fused in Sarcoma (FUS) mRNA, leading to increased FUS protein levels and promoting circFndc3b cyclization. These results suggest that circFndc3b mediates exercise‐induced anti‐pyroptotic effects via the ENO1/Klf2 axis, and a circFndc3b/ENO1/FUS positive feedback loop may potentiate exercise's neuroprotective effects. This study unveils a novel mechanism underlying exercise‐induced neuroprotection in ischemic stroke and positions circFndc3b as a promising therapeutic target for stroke management, mimicking the beneficial effects of exercise.
A Cardiac‐Targeting and Anchoring Bimetallic Cluster Nanozyme Alleviates Chemotherapy‐Induced Cardiac Ferroptosis and PANoptosis
Authors: Xing Junyue , Ma Xiaohan , Yu Yanan , Xiao Yangfan , Chen Lu , Yuan Weining , Wang Yingying , Liu Keyu , Guo Zhiping , Tang Hao , Fan Kelong , Jiang Wei 
Published: October 2024

AbstractDoxorubicin (DOX), a potent antineoplastic agent, is commonly associated with cardiotoxicity, necessitating the development of strategies to reduce its adverse effects on cardiac function. Previous research has demonstrated a strong correlation between DOX‐induced cardiotoxicity and the activation of oxidative stress pathways. This work introduces a novel antioxidant therapeutic approach, utilizing libraries of tannic acid and N‐acetyl‐L‐cysteine‐protected bimetallic cluster nanozymes. Through extensive screening for antioxidative enzyme‐like activity, an optimal bimetallic nanozyme (AuRu) is identified that possess remarkable antioxidant characteristics, mimicking catalase‐like enzymes. Theoretical calculations reveal the surface interactions of the prepared nanozymes that simulate the hydrogen peroxide decomposition process, showing that these bimetallic nanozymes readily undergo OH⁻ adsorption and O₂ desorption. To enhance cardiac targeting, the atrial natriuretic peptide is conjugated to the AuRu nanozyme. These cardiac‐targeted bimetallic cluster nanozymes, with their anchoring capability, effectively reduce DOX‐induced cardiomyocyte ferroptosis and PANoptosis without compromising tumor treatment efficacy. Thus, the therapeutic approach demonstrates significant reductions in chemotherapy‐induced cardiac cell death and improvements in cardiac function, accompanied by exceptional in vivo biocompatibility and stability. This study presents a promising avenue for preventing chemotherapy‐induced cardiotoxicity, offering potential clinical benefits for cancer patients.
Understanding and Mastering Multiphysical Fields Toward Dendrite‐Free Aqueous Zinc Batteries
Authors: Du Dayue , Zeng Li , Lan Nan , Luo Dan , Li Xiaolong , He Hanna , Zhang Chuhong 
Published: October 2024

AbstractAqueous zinc batteries (AZBs) have emerged as promising candidates for next‐generation grid‐scale energy storage due to their excellent safety, environmental friendliness, and abundance of Zn metal. However, undesired dendrite growth on Zn anodes, resulting from uneven Zn plating/stripping, leads to poor durability and low Coulombic efficiency, posing significant challenges for the practical application of AZBs. Multiple physical fields, the intrinsic driving force governing the distribution of electrons and ions, significantly impact Zn deposition behavior. The underlying mechanisms and regulation strategies related to this phenomenon has not been fully reviewed. This comprehensive review focuses on revealing the key physical fields influencing Zn deposition (including ionic flux, electric field, stress field, and temperature field) and summarizes the most effective control methods. Each approach is thoroughly scrutinized, highlighting its operational mechanisms, benefits, and limitations. Furthermore, the challenges and potential pathways for developing durable Zn anodes are outlined. Through in‐depth analysis of the influences of multiphysical fields on Zn deposition behavior, this review sets the foundation for enhancing the performance of Zn anodes, thereby supporting the advancement of Zn batteries commercialization.
Application of univariate, multivariate, and mixed models to the stability analysis of Ethiopian tetraploid wheat cultivars under irrigation condition
Authors: Gerema Geleta , Mengistu Girma , Bayisa Tilahun , Balcha Urgaya 
Published: October 2024

AbstractThe testing of durum wheat (Triticum turgidum subsp. durum) varieties in different irrigated environments is critical for determining the stability of their performance and adaptation. In this study, 12 popular and newly developed durum wheat varieties were examined in eight irrigated locations with the purpose of investigating genotype–environment interaction and their effect on Ethiopian tetraploid wheat yield stability across diverse environments. The field experiment has two replications with a randomized complete block design. Multivariate (analysis of variance, additive main effect and multiplicative interaction [AMMI], and genetics, genetics × environment [GGE] biplot) and univariate (bi [regression coefficient], S2d [deviation from regression], σi2 [Shukla's stability variance], Wi2 [Wricke's ecovalence], YSi [yield stability statistic], and CVi [coefficient of variance]) analysis methods were used to identify stable varieties. The AMMI analysis showed that the genetic × environmental interaction was highly significant (p > 0.01), while the genotype and environment variation were not significant. The first two principal component axes (IPCA1 and IPCA2) were highly significant (p > 0.01) and contributed 79% of the total GE interaction. Univariate statistical models indicate that Bulala is a stable, high‐yielding variety that can adapt to various environments. GGE biplot analysis revealed that the eight test environments were clustered into three mega‐environments, ranked Bulala as the most stable variety across diverse environments. The results of the combined mean analysis, multivariate and univariate models revealed that Bulala is a high yielder (3.46 tons ha−1) and stable variety across all test environments, while Mukiye variety has a high yield (3.43 tons ha−1) but is not as stable or adaptive to multiple locations. As a result, Bulala was recommended for further demonstration and popularization in test locations and places with similar agroecologies under irrigation.
Conducting Human Biology Research Using Invasive Clinical Samples: Methods, Strengths, and Limitations
Authors: Friedrich Volney K. , Hoke Morgan K. , Schurr Thedore G. 
Published: October 2024

ABSTRACTInvasive biological samples collected during clinical care represent a valuable yet underutilized source of information about human biology. However, the challenges of working with clinical personnel and the invasive nature of sample collection in biomedical studies can hinder the acquisition of sufficiently large sample sizes for robust statistical analyses. In addition, the incorporation of demographic data from participants is crucial for ensuring the inclusiveness of representative populations, identifying at‐risk groups, and addressing healthcare disparities. Drawing on both research experiences and the existing literature, this article provides recommendations for researchers aiming to undertake efficient and impactful projects involving invasive human samples. The suggested strategies include: (1) establishing productive collaborations with clinicians; (2) optimizing sample quality through meticulous collection and handling procedures; and (3) strategically implementing a retrospective model to capitalize on existing invasive sample repositories. When established, cooperative work between clinical health care workers and biological anthropologists can yield insights into human biology that have the potential to improve human health and wellbeing.
Physical Activity and Pregnancy Norms Among Daasanach Semi‐Nomadic Pastoralist Women in Northern Kenya
Authors: Sadhir Srishti , McGrosky Amanda , Ford Leslie B. , Nzunza Rosemary , Wemanya Sylvia N. , Mashaka Husna , Kinyanjui Rahab N. , Ndiema Emmanuel , Braun David R. , Rosinger Asher Y. , Pontzer Herman 
Published: October 2024

ABSTRACTObjectivesIn subsistence populations, high physical activity is typically maintained throughout pregnancy. Market integration shifts activity patterns to resemble industrialized populations, with more time allocated to sedentary behavior. Daasanach semi‐nomadic pastoralists living in northern Kenya face lifestyle heterogeneity due to the emergence of a market center. We investigate how Daasanach women manage the energetic demands of pregnancy with subsistence labor tasks and how market integration relates to variation in energetic demands, physical activity, and coping strategies.MethodsWe conducted nine focus group discussions with 72 pregnant women. We also deployed wrist‐worn fitness trackers with 21 pregnant women in two community types: central or peripheral to the market center to capture variation in market integration. Data from focus group discussions were analyzed using thematic analysis. We used multiple linear regression to examine the relationship between gestational age and physical activity.ResultsWe identified themes of increased fatigue, diet restrictions, and assistance with labor tasks during pregnancy. Gestational age negatively predicted mean daily steps, with a decrease of 1160 ± 437 steps per day with each consecutive pregnancy month. Stratified by community type, gestational age only negatively predicted mean daily steps for peripheral communities, with a decrease of 1443 ± 629 steps per day with each consecutive pregnancy month.ConclusionsResults suggest that physical activity differs with market integration early, but not late, in pregnancy. Daasanach women cope with the energetic demands of pregnancy by reducing physical activity late in pregnancy and receiving assistance with labor tasks from family and neighbors.