bluuebunny/crossref_metadata_2025_split huggingface dataset:
First report on the effective intraperitoneal therapy of insulin-dependent Diabetes mellitus in pet dogs using “Neo-Islets,” aggregates of adipose stem and pancreatic islet cells
Authors: Gooch Anna , Zhang Ping , Hu Zhuma , Son Natasha Loy , Avila Nicole , Fischer Julie , Roberts Gregory , Sellon Rance , Westenfelder Christof 
Published: June 2019

AbstractWe previously reported that allogeneic, intraperitoneally administered “Neo-Islets,” composed of cultured pancreatic islet cells co-aggregated with high numbers of immunoprotective and cytoprotective Adipose-derived Stem Cells, reestablished, through omental engraftment, redifferentiation and splenic and omental up-regulation of Regulatory T-cells, normoglycemia in autoimmune Type-1 Diabetic Non-Obese Diabetic (NOD) mice without the use of immunosuppressive agents or encapsulation devices. Based on these observations, we are currently testing this Neo-Islet technology in an FDA guided Pilot Study (INAD 012-776) in insulin-dependent, spontaneously diabetic pet dogs by the intraperitoneal administration of 2×10e5 Neo-Islets/kilogram body weight to metabolically controlled (blood glucose, triglycerides, thyroid and adrenal functions) animals under sedation and local anesthesia and ultrasound guidance. We report here initial observations on the first 4 Neo-Islet-treated, insulin dependent pet dogs that are now in the intermediate-term follow-up phase of the study (> 6 months post treatment). Current results indicate that in dogs, Neo-Islets appear to engraft, redifferentiate and physiologically produce insulin, and are neither rejected by auto- or allo-immune attacks, as evidenced by (a) an absent IgG response to the allogeneic cells contained in the administered Neo-Islets, and (b) progressively improved glycemic control that achieves up to a 50% reduction in daily insulin needs paralleled by a significant fall in serum glucose levels. This is accomplished without the use of anti-rejection drugs or encapsulation devices. No adverse or serious adverse events related to the Neo-Islet administration have been observed to date. We conclude that this minimally invasive therapy has significant translational relevance to veterinary and clinical Type 1 Diabetes Mellitus by achieving complete and at this point partial glycemic control in two species, i.e., diabetic mice and dogs, respectively.
Genome sequencing of ion-beam-induced mutants facilitates detection of candidate genes responsible for phenotypes of mutants in rice
Authors: Oono Yutaka , Ichida Hiroyuki , Morita Ryouhei , Nozawa Shigeki , Satoh Katsuya , Shimizu Akemi , Abe Tomoko , Kato Hiroshi , Hase Yoshihiro 
Published: June 2019

AbstractIon beams are physical mutagens used for plant and microbe breeding that cause mutations via a distinct mechanism from those of chemical mutagens or gamma rays. We utilized whole-exome sequencing of rice DNA in order to understand the properties of ion beam-induced mutations in a genome-wide manner. DNA libraries were constructed from selected carbon-ion-beam-induced rice mutants by capturing with a custom probes covering 66.3 M bases of nearly all exons and miRNAs predicted in the genome. A total of 56 mutations, including 24 single nucleotide variations, 23 deletions, and 5 insertions, were detected in five mutant rice lines (two dwarf and three early-heading-date mutants). The mutations were distributed among all 12 chromosomes, and the average mutation frequency in the M1 generation was estimated to be 2.7 × 10-7per base. Many single base insertions and deletions were associated with homopolymeric repeats, whereas larger deletions up to seven base pairs were observed at polynucleotide repeats in the DNA sequences of the mutation sites. Of the 56 mutations, six were classified as high-impact mutations that caused a frame shift or loss of exons. A gene that was functionally related to the phenotype of the mutant was disrupted by a high-impact mutation in four of the five lines tested, suggesting that whole-exome sequencing of ion-beam-irradiated mutants could facilitate the detection of candidate genes responsible for the mutant phenotypes.
The vasodilatory mechanism of nitric oxide and hydrogen sulfide in human mesenteric artery of colorectal cancer patients: role of potassium channels
Authors: Hassan Awat Y. , Maulood Ismail M. , Salihi Abbas 
Published: June 2019

AbstractRecent studies focused on the role of gasotransmitters in cancer progression and prevention. Therefore, this study was designed to explore the vasodilator activity of NO and H2S in human mesenteric artery of CRC patients via activation of K+ channels. For this purpose, two sets of experiments were established. The blood samples from CRC patients were obtained to detect serum levels of Endocan and MDA. Moreover, the role of K+ channels were assessed in mediating vasodilation of human mesenteric artery in response to SNP and Na2S. The level of serum Endocan was decreased in CRC patients compared to healthy individuals, while serum MDA was not changed. The arterial rings precontracted with NE were first relaxed by cumulative addition of increasing concentrations of either SNP (30nM-30μM) or Na2S (1-6mM). Then maximal relaxation rates were calculated for four times at each 15min intervals. Preincubation of arterial rings for 20min with individual K+ channels blockers were significantly reduced relaxation caused by SNP and Na2S at different time intervals. Furthermore, pretreatment of L-NAME did not change the vasodilation induced by Na2S. Vasodilation of CRC mesenteric unchanged by synergistic application of SNP and Na2S. While preincubation of arterial rings with PAG significantly enhanced vasodilation induced by SNP. In conclusion, these results indicate that endothelial dysfunction and oxidative stress do not take part in the pathogenesis of CRC. The dilatory mechanisms of NO and H2S in mesenteric arteries of CRC patients are K+ channels and time dependent, and the activity of CSE enzyme slows down the vasodilator ability of exogenous NO.
Top management commitment, corporate social responsibility and green human resource management
Authors: Yusliza M.-Y. , Norazmi Nurul Aimi , Jabbour Charbel José Chiappetta , Fernando Yudi , Fawehinmi Olawole , Seles Bruno Michel Roman Pais 
Published: June 2019

PurposeThe purpose of this paper is to analyse the relationship between top management commitment, corporate social responsibility (CSR) and green human resource management (GHRM).Design/methodology/approachA self-administered questionnaire was adopted to perform a systematic collection of data from manufacturing and service organisations in Malaysia. The partial least squares method was used for the conceptual framework of the study.FindingsThe observed findings indicate a significant positive relationship between top management commitment and CSR, as well all dimensions of GHRM. However, counterintuitively, the relationship between CSR and GHRM was found not to be as significant as expected (except for CSR and green analysis/job description), which can be explained through the emerging perspective that CSR and HRM should be linked.Research limitations/implicationsThe findings provide insights as to the nature of GHRM and how it is affected by CSR and top management commitment in an emerging economy – in this particular study, Malaysia. Moreover, the observed results highlight the crucial importance of top management commitment in implementing GHRM practices and CSR efficiently in order to create positive environmental performance.Originality/valueThe authors believe that, to date, no study has explored the links between top management commitment, CSR and GHRM using empirical data from Malaysia, as well as that this research is an important emerging topic for researchers, academicians and practitioners.
Environmental training: a systematic review of the state of the art of the theme
Authors: Stefanelli Nelson Oliveira , Teixeira Adriano Alves , Caldeira De Oliveira Jorge Henrique , Antonio Ferreira Marco , Sehnem Simone 
Published: June 2019

Purpose
The purpose of this paper is to carry out a systematic review of the state of the art of the environmental training theme and to propose a research agenda to shed light on this subject by suggesting new research in the area.

Design/methodology/approach
This is a systematic review of the state of the art of the environmental training theme.

Findings
The authors’ main contribution is the proposal of a research agenda with 11 recommendations for future research, such as conducting research in developed countries; research focusing only on environmental training; qualitative research using case studies; research that explores the co-evolution of environmental training practices with environmental management practices and with the maturity stage of environmental management in organizations; and research that addresses all aspects of environmental training phases proposed by ISO 10015: 2001.

Originality/value
This is the most recent research which conducts a systematic review of the state of the art on environmental training and proposes a research agenda with several suggestions that can guide researchers in human resources, environmental management, sustainability and supply chain management.
Moderating effects on the market orientation and strategic performance relationship in public housing
Authors: Ahmadi Zahra 
Published: June 2019

Purpose
The purpose of this paper is to examine how external factors moderate public housing companies’ (PHCs) market orientation (MO) and strategic performance (SP) relationship.

Design/methodology/approach
The quantitative method is applied to data from a survey sent to 289 PHCs in Sweden.

Findings
The results reveal moderating factors. The companies take several initiatives to inform themselves about customers’ needs and distribute the information within the company, but economic conditions, market and technological turbulence in the municipalities moderate the relationship between MO and SP. Economic conditions make it difficult for PHCs to strategically act based on market needs when making decisions and planning construction strategies (SP).

Research limitations/implications
This study is limited by focusing on PHCs, a sector that differs radically from the open market. The study highlights the effects of moderating factors that are important for companies’ SP and long-term construction strategies. From this limited focus, researchers might use the results to compare both similar and different market situations.

Practical implications
The results of the study are useful for companies facing a similar market situation of external moderating constraints. The result might be used in future research related to the area in focus.

Originality/value
This research adds new knowledge to market research by including the impact of economic conditions, which provides insight into how to develop and use market knowledge in real estate and public housing markets.
National cultural value models and reputation of MNCs
Authors: Swoboda Bernhard , Batton Nadine 
Published: June 2019

PurposeThe purpose of this paper is to provide a theoretical and empirical comparison of four major national cultural value models for perceived corporate reputation (CR) of multinational corporations (MNCs) across nations: Hofstede, Schwartz, the GLOBE study and Inglehart.Design/methodology/approachTwo consumer surveys on an MNC and on competitors in 25 countries in the year 2015 (n=20,288 and 25,397) were used for the first time to compare the roles of the cultural value models as antecedents of CR, using multilevel structural equation modeling (MSEM), which disentangles the explained variances on the country level and on the individual level.FindingsNational culture is strongly attributed to individual CR perceptions of MNCs across nations. However, the four conceptual cultural value models explain the variance differently (46.2–84.6 percent) as do particular cultural value dimensions within each model. The results are stable for both surveys.Research limitations/implicationsNovel insights into the roles of cultural value models are provided for international business research. For MNCs aiming to use their CR to attract target groups in foreign countries, this study identifies the most influential cultural value model and particular dimensions.Originality/valueThis study contributes to cultural research by deepening the understanding of the various cultural value models and their importance for MNCs. Moreover, the authors add to the CR research by providing new insights into perception differences and using the still novel MSEM.
Bro or Kook? The effect of dynamic member evaluation on incivility and resources in surf lineups
Authors: Sumpter Dana McDaniel 
Published: June 2019

Purpose
The purpose of this paper is to explore processes of group member evaluation and the interpersonal behavioral consequences of perceived group membership, within the context of a temporary group with evolving members.

Design/methodology/approach
Based on data from an autoethnographic study, the author investigates individual socialization into a new group, with a focus on how gender influences interpersonal evaluation processes. The author analyzes the interpersonal organizing behaviors of surf lineups, which are a male-dominated group that is continually socially constructed through changing membership.

Findings
Findings support an association between denial of group membership and outcomes including incivility and denial of resources. The author develops a model of dynamic member evaluation, which identifies how group members continuously evaluate proximate individuals at the stage of impending membership, with identified outcomes of those evaluations.

Research limitations/implications
A limitation of this design is that it generalizes organizing processes from a non-traditional setting to more traditional organizations. The model predicts dynamic member evaluation as individuals organize into groups in a shifting environment, with implications for scholarship on intragroup dynamics, incivility, gender and inclusion.

Practical implications
Understanding dynamic member evaluation provides a path for aspiring or new group members to employ signaling behaviors, which can help to prevent incivility and enhance resource availability. Evidence suggests that the proactive act of signaling competence may help to foster inclusion at the stage of impending membership, which is particularly important given how impending member evaluation is subject to bias. Such understanding also raises the awareness of how majority group members can manage their evaluations and refrain from letting judgments of impending members impact interpersonal behaviors, which may prevent incivility.

Social implications
The findings and resultant model illustrate the process and experience of group inclusion, showing how incivility can manifest and resources can be limited toward impending members who are excluded.

Originality/value
This study contributes to scholarship by introducing dynamic member evaluation, including the content and process of evaluation at the stage of impending membership, how resultant selective incivility can be predicted, and potential contagion effects of such incivility.
Incivility toward managers: gender differences in well-being outcomes
Authors: Holmvall Camilla M. , Sobhani Shayda Maria 
Published: June 2019

PurposeDrawing on selective incivility theory (Cortina, 2008) and the literature on gender and leadership (e.g. Vialet al., 2016), the purpose of this paper is to investigate well-being outcomes of often neglected targets of incivility – those who manage or lead the work of others. The authors examined links between managers’ experiences of incivility from those to whom they report and five well-being outcomes, controlling for co-worker and subordinate incivility.Design/methodology/approachThe authors used a cross-sectional correlational design to test the hypotheses, with a sample of 50 employees (28 females, 22 males) who supervise, manage or lead the work of others.FindingsMale and female managers reported similar levels of incivility from subordinates and higher-ups; males reported greater incivility from co-workers. Significant interactions were also found: the relationship between incivility from those higher up and positive affect (high and low intensity) and perceived impact were significantly stronger for female (vs male) managers.Research limitations/implicationsWomen did not experience greater workplace incivility than men, albeit the two-week timeframe of measurement may be too short to capture differences. The authors did, however, find evidence that well-being implications of experienced incivility from those higher up are generally stronger for female leaders.Originality/valueThe study investigates multi-source incivility directed at those in leadership/managerial positions and contributes to a growing literature seeking to understand the experiences of women in these roles. Although women in management roles may experience similar levels of incivility as men, they may interpret the behavior in a more negative light, in line with the persistence of sexism in the workplace.
Kaizen event approach: a case study in the packaging industry
Authors: Vo Brian , Kongar Elif , Suárez Barraza Manuel F. 
Published: June 2019

PurposeThe purpose of this paper is twofold: first, a case study on the application of lean production principles in a manufacturing facility is presented to demonstrate the impact of frequent and systematic use of a Kaizen event on quality and delivery performance. Second, the detailed description and analysis of the Kaizen event and its impact are provided, including a comprehensive analysis of the role of Kaizen events on employee participation and motivation.Design/methodology/approachThe study utilizes a Kaizen event’s case study data with the help of various waste detection and elimination tools and techniques. Changes in overall productivity along with potential long-term improvements in the delivery process are also analyzed and documented.FindingsPre- and post-quality measures are provided to demonstrate the results of the event on the production quality and on the performance of the overall manufacturing processes. Qualitative findings regarding performance measurements and the impact on the employees are reported.Research limitations/implicationsThe Kaizen team applied analytical techniques to one manufacturing site in North America of a company that has a manufacturing presence in 20 different countries.Originality/valueKaizen studies involving packaging operations are quite limited. This study fills this gap by detailing the Kaizen event implementation in a packaging delivery and dispensing systems manufacturer for the cosmetic industry. The implementation of this Kaizen event is detailed along with the data and techniques utilized for process improvement. The study also reports findings regarding the impact of the Kaizen event on employee participation.
Biogas or salami? An ethical analysis of two chains for end-of-lay hens
Authors: Mann Stefan , Visak Tatjana 
Published: June 2019

Purpose
Since 2010, Swiss slaughterhouses have no longer accepted end-of-lay chickens, so egg producers have had to slaughter the animals on the farm and deliver them to biogas plants for gasification. However, the producers’ association, GalloCircle, has recently contracted a German slaughterhouse to process end-of-lay chickens into meat. As a consequence, an increasing number of these animals are now transported abroad. The purpose of this paper is to compare the two chains from a utilitarian perspective.

Design/methodology/approach
An interview with a central actor is analyzed by objective hermeneutics. In addition, a utilitarian comparison of the two chains is carried out.

Findings
The interview with a core stakeholder reveals that he considers this to be worse for both the animals and the farmers. The system change has been motivated by the (either merely perceived or actual) ethical preferences of consumers. The authors ethical evaluation of the system change shows, however, that highly controversial assumptions would need to be made in order to justify it. The authors doubt that the (alleged) consumer preferences are based on a proper ethical analysis of the two options.

Practical implications
The authors make a case for rationally reconsidering the choice of sending the chickens abroad.

Originality/value
The paper shows that utilitarian analysis is useful to consciously choose between different value chains.
The impact of Minimum Energy Efficiency Standards on the UK investment market: one year on
Authors: French Nick 
Published: June 2019

Purpose
The purpose of this paper is to provide an update on how the 2018 energy efficiency legislation in the UK, Minimum Energy Efficiency Standards (MEES), is impacting upon the UK market with a particular emphasis on the investment market.

Design/methodology/approach
This practice briefing is an overview of the 2018 legislation and comments on how market awareness has changed since its introduction and the potential impact upon prices of affected properties moving forward.

Findings
This paper discusses how capital and rental values are beginning to be discounted in the market to allow for current and future liabilities under the MEES legislation. This has a significant impact on strategies for property investment.

Practical implications
The role of the property professional is to ensure that clients are fully conversant with their statutory obligations and to advise on appropriate investment strategies to optimise their property portfolios.

Originality/value
This paper provides insights on the requirements of MEES legislation to aid the property professional.
ATDC promotes the growth and invasion of hepatocellular carcinoma cells by modulating GSK‐3β/Wnt/β‐catenin signalling
Authors: Li Weizhi , Xue Hui , Li Yingchao , Li Peijie , Ma Fuquan , Liu Mengying , Kong Shuzhen 
Published: June 2019

AbstractAccumulating evidence has suggested that the ataxia telangiectasia group D complementing (ATDC) gene is an emerging cancer‐related gene in multiple human cancer types. However, little is known about the role of ATDC in hepatocellular carcinoma (HCC). In this study, we aimed to investigate the expression level, biological function and underlying mechanism of ATDC in HCC. The expression of ATDC in HCC cells was detected by quantitative real‐time polymerase chain reaction and western blot analysis. Cell growth was determined by cell counting kit‐8 assay and colony formation assay. Cell invasion was assessed by Transwell invasion assay. The activation status of Wnt/β‐catenin signalling was evaluated by the luciferase reporter assay. Functional experiments showed that the silencing of ATDC expression significantly suppressed the growth and invasion of HCC cells, whereas the overexpression of ATDC promoted the growth and invasion of HCC cells in vitro. Moreover, we showed that ATDC overexpression promoted the phosphorylation of glycogen synthase kinase (GSK)‐3β and resulted in the activation of Wnt/β‐catenin signalling. Notably, the inhibition of GSK‐3β activity significantly abrogated the tumour suppressive effect of ATDC silencing, while the silencing of β‐catenin partially reversed the oncogenic effect of ATDC overexpression. Taken together, these findings reveal an oncogenic role of ATDC in HCC and show that the suppression of ATDC impedes the growth and invasion of HCC cells associated with the inactivation of Wnt/β‐catenin signalling. Our study suggests that ATDC may serve as a potential therapeutic target for HCC.