bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manipulation of Ambient Housing Temperature To Study the Impact of Chronic Stress on Immunity and Cancer in Mice
Authors: Hylander Bonnie L. , Gordon Christopher J. , Repasky Elizabeth A. 
Published: January 2019

Abstract
Mice are the preeminent research organism in which to model human diseases and study the involvement of the immune response. Rapidly accumulating evidence indicates a significant involvement of stress hormones in cancer progression, resistance to therapies, and suppression of immune responses. As a result, there has been a concerted effort to model human stress in mice. In this article, we discuss recent literature showing how mice in research facilities are chronically stressed at baseline because of environmental factors. Focusing on housing temperature, we suggest that the stress of cool housing temperatures contributes to the impact of other imposed experimental stressors and therefore has a confounding effect on mouse stress models. Furthermore, we propose that manipulation of housing temperature is a useful approach for studying the impact of chronic stress on disease and the immune response and for testing therapeutic methods of reducing the negative effects of chronic stress.
ARTD1 in Myeloid Cells Controls the IL-12/18–IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer
Authors: Kunze Friedrich A. , Bauer Michael , Komuczki Juliana , Lanzinger Margit , Gunasekera Kapila , Hopp Ann-Katrin , Lehmann Mareike , Becher Burkhard , Müller Anne , Hottiger Michael O. 
Published: January 2019

Abstract
Mice deficient for ADP-ribosyltransferase diphteria toxin–like 1 (ARTD1) are protected against microbially induced inflammation. To address the contribution of ARTD1 to inflammation specifically in myeloid cells, we generated an Artd1ΔMyel mouse strain with conditional ARTD1 deficiency in myeloid lineages and examined the strain in three disease models. We found that ARTD1, but not its enzymatic activity, enhanced the transcriptional activation of distinct LPS-induced genes that included IL-12, TNF-α, and IL-6 in primary bone marrow–derived macrophages and LPS-induced IL-12/18–IFN-γ signaling in Artd1ΔMyel mice. The loss of Artd1 in myeloid cells also reduced the TH1 response to Helicobacter pylori and impaired immune control of the bacteria. Furthermore, Artd1ΔMyel mice failed to control tumor growth in a s.c. MC-38 model of colon cancer, which could be attributed to reduced TH1 and CD8 responses. Together, these data provide strong evidence for a cell-intrinsic role of ARTD1 in myeloid cells that is independent of its enzymatic activity and promotes type I immunity by promoting IL-12/18 expression.
The value of exfoliative cell cytology in the diagnosis of exudative pleural effusions
Authors: Tetikkurt Cuneyt , Yılmaz Nail , Tetikkurt Seza , Gundogdu Şule , Disci Rian 
Published: January 2019

The sensitivity and specificity of exfoliative cell cytology for the diagnosis of exudative pleural effusions varies widely according to the etiologic causes. The aim of this study is to assess the diagnostic value of exfoliative cell cytology for the identification of exudative pleural effusions. This is a retrospective study of the patients with an exudative pleural effusion admitted at our clinic in the last twenty years. We have conducted the clinical, the cytological findings, and the diagnostic results of six hundred patients from hospital records. Male to female ratio was 2.2:1 with a mean age of 42.8 years (range 18-78 years) among the patients. Samples were processed and evaluated according to the standard methods. Cytology results were reviewed and the patients were stratified according to the final diagnosis of their disease. Of the six hundred exudative effusions, 240 were malignant on exfoliative cytology pleural fluid alone. Adenocarcinoma was the most common type of malignancy. Tuberculosis was the second most frequent etiology for the exudative effusions followed by infection and collagen vascular diseases. Diagnostic accuracy of cytology showed a good correlation with the final diagnosis with an overall 70.1% sensitivity, 62.5% specificity, and a 95.9% positive predictive value for all exudative pleural effusions. Cytologic examination of the pleural fluid is a simple non-invasive procedure as the initial step for the diagnostic work up of patients with a pleural effusion. Exfoliative cytology provides high a final diagnostic yield for the identification of an exudative pleural effusion etiology. Furthermore, cytologic analysis leads the clinician into the correct diagnostic pathway as the most informative laboratory tool even when it was not diagnostic by itself for equivocal cases.
Effects of Arctic stratospheric ozone changes on spring precipitation in the northwestern United States
Authors: Ma Xuan , Xie Fei , Li Jianping , Zheng Xinlong , Tian Wenshou , Ding Ruiqiang , Sun Cheng , Zhang Jiankai 
Published: January 2019

Abstract. Using observations and reanalysis, we find that changes in April
precipitation variations in the northwestern US are strongly linked to March
Arctic stratospheric ozone (ASO). An increase in ASO can result in enhanced
westerlies in the high and low latitudes of the North Pacific but weakened
westerlies in the midlatitudes. The anomalous circulation over the North
Pacific can extend eastward to western North America, decreasing the water
vapor concentration in the air over the northwestern United States and
enhancing downwelling in the northwestern US, which results in decreased
precipitation there and vice versa for the decrease in ASO. Model
simulations using the Whole Atmosphere Community Climate Model version 4 (WACCM4) support the statistical analysis of observations and
reanalysis data and further reveal that the ASO influences circulation
anomalies over the northwestern US in two ways. Stratospheric circulation
anomalies caused by the ASO changes can propagate downward to the troposphere
in the North Pacific and then eastward to influence the strength of the
circulation anomalies over the northwestern US. In addition, sea surface
temperature anomalies over the North Pacific, which may be related to the ASO
changes, would cooperate with the ASO changes to modify the circulation
anomalies over the northwestern US. Our results suggest that ASO variations
could be a useful predictor of spring precipitation changes in the
northwestern US.
Sensitivity of active-layer freezing process to snow cover in Arctic Alaska
Authors: Yi Yonghong , Kimball John S. , Chen Richard H. , Moghaddam Mahta , Miller Charles E. 
Published: January 2019

Abstract. The contribution of cold-season soil respiration to the
Arctic–boreal carbon cycle and its potential feedback to the global climate
remain poorly quantified, partly due to a poor understanding of changes in
the soil thermal regime and liquid water content during the soil-freezing
process. Here, we characterized the processes controlling active-layer
freezing in Arctic Alaska using an integrated approach combining in situ soil
measurements, local-scale (∼50 m) longwave radar retrievals
from NASA airborne P-band polarimetric SAR (PolSAR) and a remote-sensing-driven permafrost model. To better capture landscape variability in snow
cover and its influence on the soil thermal regime, we downscaled global
coarse-resolution (∼0.5∘) MERRA-2 reanalysis snow
depth data using finer-scale (500 m) MODIS snow cover extent (SCE)
observations. The downscaled 1 km snow depth data were used as key inputs to
the permafrost model, capturing finer-scale variability associated with local
topography and with favorable accuracy relative to the SNOTEL site
measurements in Arctic Alaska (mean RMSE=0.16 m, bias=-0.01 m).
In situ tundra soil dielectric constant (ε) profile measurements were used
for model parameterization of the soil organic layer and unfrozen-water
content curve. The resulting model-simulated mean zero-curtain period was
generally consistent with in situ observations spanning a 2∘
latitudinal transect along the Alaska North Slope (R: 0.6±0.2; RMSE:
19±6 days), with an estimated mean zero-curtain period ranging from
61±11 to 73±15 days at 0.25 to 0.45 m depths. Along the same
transect, both the observed and model-simulated zero-curtain periods were
positively correlated (R>0.55, p<0.01) with a MODIS-derived snow cover fraction (SCF) from September to October. We also examined
the airborne P-band radar-retrieved ε profile along this transect in 2014 and
2015, which is sensitive to near-surface soil liquid water content and
freeze–thaw status. The ε difference in radar retrievals for the surface
(∼<0.1 m) soil between late August and early October
was negatively correlated with SCF in September (R=-0.77, p<0.01); areas with lower SCF generally showed larger ε reductions, indicating
earlier surface soil freezing. On regional scales, the simulated zero curtain
in the upper (<0.4 m) soils showed large variability and was closely
associated with variations in early cold-season snow cover. Areas with
earlier snow onset generally showed a longer zero-curtain period; however,
the soil freeze onset and zero-curtain period in deeper (>0.5 m)
soils were more closely linked to maximum thaw depth. Our findings indicate
that a deepening active layer associated with climate warming will lead to
persistent unfrozen conditions in deeper soils, promoting greater cold-season
soil carbon loss.
Organisatiecriminaliteit en de aanpak ervan in de Lage Landen
Authors: Van Wingerde Karin , Verhage Antoinette , Bisschop Lieselot 
Published: January 2019

Corporate crime and its enforcement in the Netherlands and Belgium
In this introductory article we will discuss some of the recent developments in corporate crime research in the Netherlands and Belgium since 2008. In doing so, we will answer the following three questions: (1) What are the most important developments in the way research on corporate crime has been carried out? (2) What are key themes in corporate crime research? (3) What are the most important blind spots in research into corporate crime? We will conclude with some avenues for future research on corporate crime and its enforcement.
Patronen in regelovertreding in de chemische industrie
Authors: Kluin Marieke , Blokland Arjan , Huisman Wim , Peeters Marlijn , Wiering Ellen , Jaspers Steven 
Published: January 2019

Patterns of regulatory violations in chemical corporations
Unlike criminal career research into the criminal behavior of natural persons, longitudinal research into rule violations by corporations is still scant. The few available studies are mostly limited to US corporations, and suffer from either a small sample size or a short follow-up period, limiting the generalizability of their findings. The present study uses longitudinal data on rule violating behavior of 494 Dutch chemical corporations derived from yearly inspections (N=4.367) of the relevant safety and environmental agencies between 2006 and 2017. The study aims to gain insight in the patterning of rule violations by Dutch chemical corporations, and the extent to which these patterns are associated with sector and corporate characteristics. The results show that rule violation is common among Dutch chemical corporations. A small minority of chronically violating corporations however, is responsible for a disproportional share of all observed rule violations. Using group-based trajectory modelling (GBTM) we distinguish several longitudinal patterns of rule violations in our data. Available sector and corporation characteristics are only weakly associated with the patterns of rule violations identified.
Lolita’s Love Affair with the English Language: Heterolingualism and Voice in Translation
Authors: Vale de Gato Margarida 
Published: January 2019

This article is a first-person account of the translation of Lolita into Portuguese dealing primarily with the question of how to treat English as a source language that should be replaced by the translating language. The novel foregrounds the narrator’s stridency as a non-“native illusionist” (Nabokov 1955/1991: 317), along with a heterolingual bend, presenting remarkable challenges for translation: how to represent the geopolitics of linguistic hybridity in the TT and how to maintain the ambiguity of alignments between (implied) reader(s), author(s) and competing instances of narratorial authority, including the “fictional translator” (Klinger 2015: 16).
Selective non-translation is suggested as an option for addressing linguistic hybridity through which, in this context, the “differential voice(s)” (Hermans 2007; Suchet: 2013) might foreground linguistic (and hence cultural/ideological) difference and deviation. The adherence to a strategy of “overt translation” (House 2001) is not intended to break the “translator’s pact” (Alvstad: 2014); it refuses, however, the convention of transparency as one of its tenets. It also shifts the focus from phonocentric authority to a polyphonous palimpsest and an archaeology of language(s) – not an entrenched foreignization, but an availability for “other-languagedness” (Bakhtin: 1981).
Variation dénominative avec conséquences cognitives : quelques exemples détectés autour de « musée »
Authors: Joan Casademont Anna 
Published: January 2019

Cet article se veut une contribution à la description des phénomènes liés au caractère dynamique des discours spécialisés. Concrètement, nous y analysons la variation dénominative (avec conséquences cognitives) dans le domaine de la muséologie et de la muséographie dans un corpus en langue espagnole, et ce, pour les unités présentant le morphèmemuse(o)-extraites à l’aide de l’outilTermoStat(Drouin 2003). Pour ce faire, nous partons de la typologie de la variation dénominative proposée par Fernández-Silva (2013), ce qui nous permet de : (a) confirmer que la typologie est pertinente dans d’autres disciplines que celle pour laquelle elle a été créée, c’est-à-dire la pêche ; (b) relever et caractériser des tendances sur le plan de la variation, si elles existent, dans le domaine des musées. Cela permettra d’orienter postérieurement des choix lexicographiques vers l’information pertinente à expliciter.
L’horizon et le destin de la phénoménologie
Authors: Djian Aurélien 
Published: January 2019

L’ambition de cet article est double. Il s’agit d’abord de fixer le contexte philosophique qui sous-tend le débat entre Derrida et Marion en 1999, à l’Université de Villanova, et de réviser la perspective qui y est formulée selon laquelle le destin de la phénoménologie est intimement lié à une décision à prendre à l’égard du concept d’horizon : « il n’y a pas de phénoménologie sans horizon », affirme Derrida à Marion, il faut donc la dépasser ; « la dernière étape en vue d’une véritable phénoménologie serait d’abandonner le concept d’horizon », rétorque Marion à Derrida. Cette révision de perspective nous conduira alors, dans un second temps, à restituer, en se servant de l’histoire du concept d’horizon comme fil directeur heuristique, le sens de ce que nous appellerons l’histoire française de l’herméneutique phénoménologique, dont l’unité, par-delà la multiplicité des étiquettes, réside dans le partage d’une même définition de l’activité philosophique, comme tentative de laisser se montrer soi-même à partir de soi-même le phénomène par excellence, et, avec et contre le second Heidegger, d’une même exigence de dépassement de l’horizon, solidaire de la métaphysique moderne de la subjectivité. Le principe d’une telle reconstruction permettra enfin d’envisager la possibilité d’une histoire différenciée des concepts alternatifs de phénoménologie et d’horizon, qui reste à écrire.
Politiser ou privatiser l’ethnie ? Réflexion à propos du bien commun en Afrique postcoloniale
Authors: BAMAZE N’GANI Essodina 
Published: January 2019

En raison de fortes tensions ethniques qui le mettent en branle, l’État en Afrique vit un délitement du tissu collectif. Dans un contexte de pluralisme ethnique fort, la négation de ce pluralisme par la politique d’assimilation a eu pour effet contraire l’édification d’un sectarisme ethnique donnant lieu à une instabilité socio-politique. En réaction, la prise en considération institutionnelle de l’ethnie n’a pu empêcher cette instabilité. Oscillant ainsi entre politique d’assimilation et naturalisation normative de l’ethnie, l’État y vit une crise du bien commun. Le présent article vise à montrer que la gestion du pluralisme ethnique en Afrique ne saurait se réduire à de simples dispositions politico-juridiques. Il s’agit bien plutôt de promouvoir la perspective de la postcommunauté qui vient fédérer trois types de mobilisations enchevêtrées : l’une relative à la conscience, l’autre à la participation de toutes les composantes communautaires au bien commun, enfin celle relative aux nouvelles responsabilités de l’État.
The Education of Inuit Youth in Nunavik: Teachers’ and Students’ Perspectives
Authors: Garakani Tatiana 
Published: January 2019

This article draws on data collected in Nunavik between 2011 and 2014 to describe the perceptions of Inuit students and their teachers (Inuit and non-Inuit) about their motivation, the purpose of schooling, the quality of their relationships, and the pedagogical choices and approaches that influence their perseverance. Informed by critical Indigenous methodologies, the research was conducted with the approval of Kativik Ilisarniliriniq, the School Board of Nunavik. A wide range of research tools was used to facilitate participation by teachers from the French, English, and Inuit sectors, in elementary (Kindergarten to Grade 6) and high school (Grades 7 to 11), and participation by students from the French and English sectors (Grades 8 to 11).
A Hunger to Teach: Recruiting Inuit Teachers for Nunavut
Authors: Berger Paul , Inootik Karen , Jones Rebecca , Kadjukiv Jennifer 
Published: January 2019

We describe findings from participatory research conducted by a southern-based researcher from Thunder Bay, Ontario, and Nunavut Arctic College’s Teacher Education Program students. Together, they interviewed 128 high school students from 11 communities to determine what attracts Inuit youth to teaching and what might discourage them from becoming teachers. The research was based on the premise that Nunavut’s schools cannot be Inuit schools without many more Inuit teachers. We found that many Inuit youth have considered becoming teachers, but they face barriers to doing so. They expressed concerns about housing, finances, leaving their home communities, and their own academic preparedness. Many lacked information about teacher education programs. We recommend addressing these concerns, in part, by using Nunavut Teacher Education Program students to educate high school students about the program and to encourage them to become teachers.
Le partenariat université-communautés au service du développement d’un curriculum scolaire en inuktitut : Pistes de travail et de réflexion
Authors: Pellerini Glorya , Maheux Gisèle , Bacon Lily , Paul Véronique , Angiyou Sarah , Mangiuk Passa 
Published: January 2019

Les communautés d’Ivujivik et de Puvirnituq (Nunavik, Canada), en association avec l’Université du Québec en Abitibi-Témiscamingue (UQAT), collaborent depuis plus de 30 ans à un projet de développement de l’éducation. Afin d’en faire un bilan, les partenaires inuit et universitaires ont organisé en novembre 2015, à Puvirnituq, un colloque ouvert à la population ainsi qu’aux acteurs intéressés par l’éducation au Nunavik. Une analyse partielle du contenu des échanges et des communications portant sur le processus de partenariat, les composantes du curriculum scolaire et son développement en inuktitut a été réalisée en lien avec les concepts de « dialogue interculturel » et de « curriculum ». Les résultats préliminaires sont ici présentés et laissent entrevoir la complexité méconnue du parcours scolaire des élèves inuit et du travail des enseignants auprès d’eux. Ils soulèvent la question de l’émergence d’une troisième culture, observable à travers la pratique dialogique développée.
Temporal whole field sawtooth flicker without a spatial component elicits a myopic shift following optical defocus irrespective of waveform direction in chicks
Authors: Murphy Melanie J. , Riddell Nina , Crewther David P. , Simpson David , Crewther Sheila G. 
Published: January 2019

Purpose
Myopia (short-sightedness) is the commonest visual disorder and greatest risk factor for sight threatening secondary pathologies. Myopia and hyperopia can be induced in animal models by rearing with optical lens defocus of opposite sign. The degree of refractive compensation to lens-induced defocus in chicks has been shown to be modified by directionally drifting sawtooth spatio-temporal luminance diamond plaids, with Fast-ON sawtooth spatio-temporal luminance profiles inhibiting the myopic shift in response to negative lenses, and Fast-OFF profiles inhibiting the hyperopic shift in response to positive lenses. What is unknown is whether similar sign-of-defocus dependent results produced by spatio-temporal modulation of sawtooth patterns could be achieved by rearing chicks under whole field low temporal frequency sawtooth luminance profiles at 1 or 4 Hz without a spatial component, or whether such stimuli would indiscriminately elicit a myopic shift such as that previously shown with symmetrical (or near-symmetrical) low frequency flicker across a range of species.

Methods
Hatchling chicks (n = 166) were reared from days five to nine under one of three defocus conditions (No Lens, +10D lens, or −10D lens) and five light conditions (No Flicker, 1 Hz Fast-ON/Slow-OFF sawtooth flicker, 4 Hz Fast-ON/Slow-OFF sawtooth flicker, 1 Hz Fast-OFF/Slow-ON sawtooth flicker, or 4Hz Fast-OFF/Slow-ON sawtooth flicker). The sawtooth flicker was produced by light emitting diodes (white LEDs, 1.2 –183 Lux), and had no measurable dark phase. Biometrics (refraction and ocular axial dimensions) were measured on day nine.

Results
Both 1 Hz and 4 Hz Fast-ON and Fast-OFF sawtooth flicker induced an increase in vitreous chamber depth that was greater in the presence of negative compared to positive lens defocus. Both sawtooth profiles at both temporal frequencies inhibited the hyperopic shift in response to +10D lenses, whilst full myopic compensation (or over-compensation) in response to −10D lenses was observed.

Conclusions
Whole field low temporal frequency Fast-ON and Fast-OFF sawtooth flicker induces a generalized myopic shift, similar to that previously shown for symmetrical sine-wave and square-wave flicker. Our findings highlight that temporal modulation of retinal ON/OFF pathways per se (without a spatial component) is insufficient to produce strong sign-of-defocus dependent effect.