bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Risk of Impingement With Sexual Activity in Femoroacetabular Impingement Syndrome Due to Cam Morphology: Shape Matters
Authors: Sochacki Kyle R. , Yetter Thomas R. , Morehouse Hannah , Delgado Domenica , Nho Shane J. , Harris Joshua D. 
Published: August 2018

Background: Sexual difficulties and dysfunction are common in patients with femoroacetabular impingement syndrome (FAIS) secondary to hip pain and stiffness. Purpose: To determine the risk of impingement in patients with FAIS during common sexual positions using 3-dimensional computer-simulated collision detection before and after cam correction. Study Design: Descriptive laboratory study. Methods: Ten computed tomography scans of the pelvis and femur from patients with FAIS due to isolated cam morphology were retrospectively reviewed. Three-dimensional osseous models were developed using Mimics software. The cam deformity was then completely corrected. Simulations of hip range of motion for the most common sexual positions for men (n = 15) and women (n = 14) were conducted before and after cam resection. Impingement was determined for each sexual position. Position safety was defined as ≤20% of models demonstrating impingement in a position. Descriptive and simple comparative statistics were calculated. Results: There was no sexual position that was impingement free in all models before cam correction. After cam correction, 11 (37.9%) of 29 total positions were impingement free. There was a significant decrease in impingement from before to after cam correction (40.7% vs 11.4%, respectively, of all female positions [ P < .0001]; 26.0% vs 6.7%, respectively, of all male positions [ P < .0001]). There was a significant increase in the number of “safe” positions from before to after cam correction (4 vs 11, respectively, of all female positions [ P = .008]; 7 vs 15, respectively, of all male positions [ P = .001]). Conclusion: After cam correction, there was a significant reduction in the impingement rate and a significant increase in the number of “safe” sexual positions. Clinical Relevance: Impingement in patients with cam morphology is common during sexual activity. Surgical correction of cam morphology significantly reduces the rate of impingement. Although this laboratory imaging-only study did not account for patient symptoms, this likely translates to significant symptomatic improvement during sexual activity after surgical cam correction.
Parent perspectives on autistic girls’ friendships and futures
Authors: Sedgewick Felicity , Hill Vivian , Pellicano Elizabeth 
Published: August 2018

Background and aims Young people’s parents often play a key role in facilitating friendships and have their own views on these friendships. Yet parents have rarely been asked to report on the friendships and peer relationships of their autistic children. This study therefore sought to examine parents’ perspectives on the friendships and social difficulties of their autistic daughters, and their views and concerns about their daughters’ futures. Methods Twenty parents of autistic adolescent girls, aged between 11 and 18 years, took part in semi-structured interviews on the topics of friendships, conflict and thoughts about adulthood and the future. Results Results demonstrated that parents often have significant involvement in their daughters’ social lives and friendships and have a range of views on these relationships. They highlighted both benefits and pitfalls of their daughters’ peer interactions, and the perceived negative influence of these interactions on their daughters’ mental health. Most parents had significant concerns about their daughters’ futures, either about their ability to live independently, or their potential vulnerability to exploitation. Despite these concerns around sexual relationships, some parents were avoiding raising the issue with their daughters. Conclusions Adolescent autistic girls often have positive, close friendships, but can also be the victims of bullying, with significant negative impacts on their mental health, at least according to their parents. Concerns about girls’ development into adulthood were commonplace, with parents taking a range of approaches to attempt to talk about the future with their daughters. Implications There is an urgent need for more open conversations to help autistic girls stay safe and secure as they mature, supporting their ability to understand and negotiate more intimate social relationships. Future research should examine these changing relationships as autistic girls’ transition to adulthood and should seek to combine the views of parents alongside the young people themselves.
High-Speed Video Analysis of Syndesmosis Injuries in Soccer—Can It Predict Injury Mechanism and Return to Play? A Pilot Study
Authors: Jain Neil , Murray David , Kemp Steve , Calder James 
Published: August 2018

Background: Ankle syndesmosis injuries in professional soccer may lead to an unpredictable and prolonged recovery. This injury has been investigated in anatomical and radiologic studies but the precise mechanism leading to syndesmosis injury is not well understood and remains debated. The 2 goals of this study were to (1) evaluate the relationship between the mechanism of syndesmosis injury as determined by high-speed video analysis and the injured structures identified by clinical and radiologic examination and to (2) investigate the relationship between mechanism of injury and time of return to play. Methods: This pilot study prospectively reviewed high-speed video analysis of 12 professional soccer players who sustained syndesmosis injuries. The mechanism of injury was compared with the clinical and MRI evaluation and the time taken to return to play. Results: Higher-grade syndesmosis injuries occurred during ankle external rotation with dorsiflexion. Supination-inversion injuries with a standard lateral ankle sprain (rupture of the anterior talofibular ligament) may extend proximally, causing a lower-grade syndesmosis injury. These may present with signs of a high ankle sprain but have a quicker return to sport than those following a dorsiflexion-external rotation injury (mean 26 days vs 91 days). Conclusions: Video analysis confirmed that at least 2 mechanisms may result in injury to the ankle syndesmosis. Those “simple” ankle sprains with signs of syndesmosis injury had a quicker return to play. This new finding may be used by club medical teams during their initial assessment and help predict the expected time away from soccer in players with suspected high ankle sprains. Level of Evidence: Level IV, retrospective cohort study.
Comorbid Dysphagia and Dyspnea in Muscle Tension Dysphonia: A Global Laryngeal Musculoskeletal Problem
Authors: McGarey Patrick O. , Barone Nicholas A. , Freeman Michael , Daniero James J. 
Published: August 2018

ObjectiveTo characterize the associated symptoms of dysphagia and dyspnea among patients presenting with muscle tension dysphonia (MTD).Study DesignRetrospective chart review performed over a 14‐month period from October 2014 to December 2015.SettingVoice and swallowing center of a tertiary academic medical center.Subjects and MethodsThirty‐eight patients with MTD were included for analysis. Clinical data were collected and analyzed, including perceptual voice evaluation and patient‐reported outcomes measures.ResultsAmong patients with a diagnosis of MTD, the incidence of reported dysphagia during clinical history and examination was 44.7%. Among patients with MTD, 60.5% had an EAT‐10 (10‐item Eating Assessment Tool) score ≥3 (ie, abnormal). Patients who reported dysphagia and/or had abnormal EAT‐10 score (≥3) had significantly greater voice impairment than that of patients without dysphagia (P =. 02). Patients who reported dysphagia also had significantly higher Clinical COPD Questionnaire scores than those of patients who reported only dysphonia (P =. 002).ConclusionsPatients presenting for dysphonia who are diagnosed with MTD have a high rate of comorbid dysphagia. Patients who reported dysphagia had significantly higher self‐reported voice impairment and greater severity of breathing dysfunction as measured by the Clinical COPD Questionnaire. The coincidence of these symptoms in this patient cohort may suggest an underlying pathophysiology that has yet to be elucidated. Further prospective studies are needed to clarify the underlying cause of dysphagia and breathing dysfunction in the setting of MTD and to investigate diagnostic and therapeutic paradigms.
Interaction between the microbiome and TP53 in human lung cancer
Authors: Greathouse K. Leigh , White James R. , Vargas Ashely J. , Bliskovsky Valery V. , Beck Jessica A. , von Muhlinen Natalia , Polley Eric C. , Bowman Elise D. , Khan Mohammed A. , Robles Ana I. , Cooks Tomer , Ryan Bríd M. , Padgett Noah , Dzutsev Amiran H. , Trinchieri Giorgio , Pineda Marbin A. , Bilke Sven , Meltzer Paul S. , Hokenstad Alexis N. , Stickrod Tricia M. , Walther-Antonio Marina R. , Earl Joshua P. , Mell Joshua C. , Krol Jaroslaw E. , Balashov Sergey V. , Bhat Archana S. , Ehrlich Garth D. , Valm Alex , Deming Clayton , Conlan Sean , Oh Julia , Segre Julie A. , Harris Curtis C. 
Published: August 2018

Abstract

Background
Lung cancer is the leading cancer diagnosis worldwide and the number one cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer, reduces epithelial barrier integrity and increases susceptibility to infections. Herein, we hypothesize that somatic mutations together with cigarette smoke generate a dysbiotic microbiota that is associated with lung carcinogenesis. Using lung tissue from 33 controls and 143 cancer cases, we conduct 16S ribosomal RNA (rRNA) bacterial gene sequencing, with RNA-sequencing data from lung cancer cases in The Cancer Genome Atlas serving as the validation cohort.

Results
Overall, we demonstrate a lower alpha diversity in normal lung as compared to non-tumor adjacent or tumor tissue. In squamous cell carcinoma specifically, a separate group of taxa are identified, in which Acidovorax is enriched in smokers. Acidovorax temporans is identified within tumor sections by fluorescent in situ hybridization and confirmed by two separate 16S rRNA strategies. Further, these taxa, including Acidovorax, exhibit higher abundance among the subset of squamous cell carcinoma cases with TP53 mutations, an association not seen in adenocarcinomas.

Conclusions
The results of this comprehensive study show both microbiome-gene and microbiome-exposure interactions in squamous cell carcinoma lung cancer tissue. Specifically, tumors harboring TP53 mutations, which can impair epithelial function, have a unique bacterial consortium that is higher in relative abundance in smoking-associated tumors of this type. Given the significant need for clinical diagnostic tools in lung cancer, this study may provide novel biomarkers for early detection.
The Gonadotropin-Releasing Hormone Pulse Generator
Authors: Herbison Allan E 
Published: August 2018

AbstractThe pulsatile release of GnRH and LH secretion is essential for fertility in all mammals. Pulses of LH occur approximately every hour in follicular-phase females and every 2 to 3 hours in luteal-phase females and males. Many studies over the last 50 years have sought to identify the nature and mechanism of the “GnRH pulse generator” responsible for pulsatile LH release. This review examines the characteristics of pulsatile hormone release and summarizes investigations that have led to our present understanding of the GnRH pulse generator. There is presently little compelling evidence for an intrinsic mechanism of pulse generation involving interactions between GnRH neuron cell bodies. Rather, data support the presence of an extrinsic pulse generator located within the arcuate nucleus, and attention has focused on the kisspeptin neurons and their projections to GnRH neuron dendrons concentrated around the median eminence. Sufficient evidence has been gathered in rodents to conclude that a subpopulation of arcuate kisspeptin neurons is, indeed, the GnRH pulse generator. Findings in other species are generally compatible with this view and suggest that arcuate/infundibular kisspeptin neurons represent the mammalian GnRH pulse generator. With hindsight, it is likely that past arcuate nucleus multiunit activity recordings have been from kisspeptin neurons. Despite advances in identifying the cells forming the pulse generator, almost nothing is known about their mechanisms of synchronicity and the afferent hormonal and transmitter modulation required to establish the normal patterns of LH pulsatility in mammals.
Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells
Authors: Nakajima Taiki , Shibata Mitsuaki , Nishio Megumi , Nagata Sanae , Alev Cantas , Sakurai Hidetoshi , Toguchida Junya , Ikeya Makoto 
Published: August 2018

ABSTRACTSomites (SMs) comprise a transient stem cell population that gives rise to multiple cell types, including dermatome (D), myotome (MYO), sclerotome (SCL) and syndetome (SYN) cells. Although several groups have reported induction protocols for MYO and SCL from pluripotent stem cells, no studies have demonstrated the induction of SYN and D from SMs. Here, we report systematic induction of these cells from human induced pluripotent stem cells (iPSCs) under chemically defined conditions. We also successfully induced cells with differentiation capacities similar to those of multipotent mesenchymal stromal cells (MSC-like cells) from SMs. To evaluate the usefulness of these protocols, we conducted disease modeling of fibrodysplasia ossificans progressiva (FOP), an inherited disease that is characterized by heterotopic endochondral ossification in soft tissues after birth. Importantly, FOP-iPSC-derived MSC-like cells showed enhanced chondrogenesis, whereas FOP-iPSC-derived SCL did not, possibly recapitulating normal embryonic skeletogenesis in FOP and cell-type specificity of FOP phenotypes. These results demonstrate the usefulness of multipotent SMs for disease modeling and future cell-based therapies.
Caucasian and south Asian men show equivalent improvements in surrogate biomarkers of cardiovascular and metabolic health following 6-weeks of supervised resistance training
Authors: Knox Allan , Sculthorpe Nicholas , Grace Fergal 
Published: August 2018

Background: The South Asian population have greater cardiovascular risk than their age-matched Caucasian counterparts, characterized by unfavorable biomarkers. South Asians may also be partially resistant to the pleiotropic benefits of physical activity on cardiovascular health. There is a current absence of studies that compare markers of cardio-metabolic health between Caucasians and South Asians employing resistance exercise. This study set out to compare the response in biomarkers of cardio-metabolic health in Caucasians and South Asians in response to resistance exercise.Methods: Caucasian (n=15, 25.5 ± 4.8 yrs) and South Asian (n=13, 25.4 ± 7.0 yrs) males completed a 6-week progressive resistance exercise protocol. Fasting blood glucose, insulin, and their product insulin resistance (HOMA-IR), triglycerides (TRIGS), low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol (TC), vascular endothelial growth factor (VEGF), asymmetric dimythylarginine (ADMA), L-arginine (L-ARG) and C-reactive protein (CRP) were established at baseline and following resistance exercise.Results: There were significant improvements in fasting glucose, TC, LDL, HDL and VEGF in both groups following resistance exercise (p<0.05, for all). No change was observed in insulin, HOMA-IR, TRIGS, ADMA, L-ARG following resistance exercise (p>0.05, in both groups). CRP increased in the South Asian group (p<0.05) but not the Caucasian group (p>0.05)Conclusions: The cardio-metabolic response to resistance exercise is comparable in young Caucasian and South Asian males though inflammatory response to exercise may be prolonged in South Asians.
FastQ Screen: A tool for multi-genome mapping and quality control
Authors: Wingett Steven W. , Andrews Simon 
Published: August 2018

DNA sequencing analysis typically involves mapping reads to just one reference genome. Mapping against multiple genomes is necessary, however, when the genome of origin requires confirmation. Mapping against multiple genomes is also advisable for detecting contamination or for identifying sample swaps which, if left undetected, may lead to incorrect experimental conclusions. Consequently, we present FastQ Screen, a tool to validate the origin of DNA samples by quantifying the proportion of reads that map to a panel of reference genomes. FastQ Screen is intended to be used routinely as a quality control measure and for analysing samples in which the origin of the DNA is uncertain or has multiple sources.
Let the bird fly: Somatic practice and Sufi hadra performance, the embodied experience
Authors: Rodrigues Jamila 
Published: August 2018

Abstract
Based on an ethnographic case study conducted amidst the Sufi women of the Naqshbandi group in Cape Town South Africa in 2013/14, this article discusses and analyses Sufi women’s verbalized ideas of the embodied ritual practice named hadra. From their experience with the ritual I argue that body and mind can somatically co-habit in a relationship in Sufi religious ritual practice. I challenge Sufi women’s ideas of an ‘outside of the body’ and ‘inside of the body’ experience during the fan’a, or final stage of the ritual. This article argues that when body and mind are connected within ritual praxis, an embodied experience is generated; this holistic experience goes beyond current Sufi theological thinking. This theory is evidenced in my research through an analysis of how dancers make sense of their own body and movement experience.
‘No mind’: A Zen Buddhist perspective on embodied consciousness
Authors: Sakuta Aska 
Published: August 2018

Abstract
This article explores the idea of a deeply embodied consciousness during movement, which has become one of the most intensely discussed topics in terms of the phenomenology and spirituality of dance and somatic practices. The strive towards an embodied state of consciousness has been historically present in the context of Zen Buddhist philosophy, wherein true embodiment is considered an enlightened state of being, wherein one’s consciousness transcends the barriers of mind versus body, self versus other and human versus non-human; it is thought that, in this state, we experience a visceral enlightenment towards our inherent connection to (or interrelation with) the spiritual and physical world around us, and that this state is a form of ‘purified’ – or even optimal – being. Phenomenological aspects underpinning this paradigm will be unpacked through representative cases of eastern movement practices whose founding philosophies align with Zen Buddhist thought. Among these movement practices will be Nihon-buyo (Japanese traditional dance), eastern martial arts and Butoh, which all utilize movement as a meditative process towards a state of selfworld transcendence. At the end of the article, the phenomenon of deeply embodied consciousness will be reframed and explained through the lens of neurophenomenology, with the aim of bringing forth the validity and relevance of this phenomenon in the newly emerging scientific research of consciousness and attention.
Shamanic striptease
Authors: Hamilton Mark James 
Published: August 2018

Abstract
This article explores a performance called Salvation: Shamanic Striptease. It considers how my co-creation of this spiritual–erotic work with white South African performer Daniel P. Cunningham1 has elaborated ‘shamanic striptease’ – an emergent practice through which he seeks to discover movement and vocalization (words and song) that yield deep significance for him (as performer) and for those who witness his performance. This is a process in which somatic and semiotic meaning are negotiated. Inspired by the vision of seminal Polish theatre practitioner Jerzy Grotowski (1933–99), shamanic striptease looks for what might be called naïve expression, that is, a close merging of intention and action that generates a dense performance open to multiple interpretations. Our working process opens up considerations of the relationships between performers’ and audiences’ experiences, the multivalence of identity and searches for the transcendental in a cosmopolitan context of London. Special consideration is given in this essay to how the identity politics of postcolonial white settler culture intersect with queer cisgender expressions of masculinity.
Be still and know: Authentic Movement, witness and embodied testimony
Authors: McMillan Christopher-Rasheem 
Published: August 2018

Abstract
The article looks at dance narratives and the body, investigating the somatic and spiritual practice of Authentic Movement. Be Still and Know: Authentic Movement, Witness, and Testimony considers the movement practice of Authentic Movement as a possible creative source for ‘bodily becoming.’ This article also traces the practice of Authentic Movement, which sits on the intersections of dance and spirituality, from its origins to new applications, and even its application to Body Theology. To view this physical practice as a way of meaning-making in the context of dance knowledge, and as a methodology for analyzing the body, arguably adds new ways of reflecting on biblical knowledge. As a bodily practise, Authentic Movement has the possibility of grounding a reflective theologising through the somatic body. This article uses a phenomenology of testimony as a performative mode of providing both location, context, and proof for the experiences that are documented through Authentic Movement practice. In this article I unfold the term ‘witness’ used prolifically in Authentic Movement in relation to my own religious embodiment growing up in the South as a child of a minister, demonstrating how terminology in Authentic Movement slips its taken-for-granted understandings. Thus, I expand the practice of Authentic Movement beyond its useful application and normative usage.
Image, imagination and the social imaginary: Solo improvisational dances of North Africa and the Middle East
Authors: Sellers-Young Barbara 
Published: August 2018

Abstract
The solo improvisational dances of North Africa and the Middle East became part of popular discourse following Napoleon’s conquering of Egypt. Jean-Léon Gérôme (1824–1904) and other visual artists painted images depicting the dancers. Gustave Flaubert (1821–80) and others penned narratives of encounters with dancers. Oscar Wilde (1854–1900) wrote his play Salome (1893). Sol Bloom created the street scenes of dancers for the 1893 Chicago World’s Fair. Hollywood turned out countless ‘blood, sex and sand films’ by stars such as Rudolph Valentino (1895–1926). These images created in the nineteenth and early twentieth century became fixed in the popular imagination and dictated the conception of the dances of North Africa and the Middle East, and ultimately the ethos of the region itself. This article considers the impact these images have had on what Arjun Appadurai refers to as the social imaginary. By extension, it examines the impact of the imagination created within the vocabulary of the dances on the dialogue between North Africa and the Middle East, and the global community, including those who trace their lineage to this area and those who do not.