bluuebunny/crossref_metadata_2025_split huggingface dataset:
Durable flame‐retardant and antidroplet finishing of polyester fabrics with flexible polysiloxane and phytic acid through layer‐by‐layer assembly and sol–gel process
Authors: Jiang Zhenlin , Wang Chaosheng , Fang Shuying , Ji Peng , Wang Huaping , Ji Chengchang 
Published: March 2018

ABSTRACTA three‐layer functional coating was prepared through layer‐by‐layer (LbL) assembly and a sol–gel process. The multilayered coating was composed of a phytic acid (PA) coating dipped between two layers of flexible polysiloxane coatings and was deposited on the polyester fabric by LbL assembly. Flammability tests indicated that the multilayer coating prevented droplet generation during combustion. The PA also absorbed the reactive free radicals to reduce the flame‐burning rate. After being soaked for only 20 min in PA solution, the fabric exhibited self‐extinguishing properties and antidroplet effect during the vertical flame test, while cone calorimetry confirmed that the coated fabric exhibited a 65% decrease in the peak heat release rate and reduced the total amount of smoke released by 72%. After washing the coated fabric 45 times, there was no significant decrease in the phosphorus content and the limiting oxygen index of coated fabrics. Thus, the coating synthesized in this study is an effective method of constructing durable, functional coatings on the surface of fabrics. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46414.
Molecular and functional characterization of three odorant binding proteins from the oriental fruit moth Grapholita molesta (Busck) (Lepidoptera: Tortricide)
Authors: Chen Xiu‐Lin , Su Li , Li Bo‐Liao , Li Guang‐Wei , Wu Jun‐Xiang 
Published: March 2018

AbstractOdorant binding proteins (OBPs) act in recognizing odor molecules and their most well‐studied functions are transporting odors across the sensillum lymph to olfactory receptor neurons within the insect antennal sensillum. The adults of Grapholita molesta highly depend on olfactory cues in locating host plants and selecting oviposition sites, in which OBPs play an important role in perceiving and recognizing host plant volatiles. Exploring the physiological function of OBPs could facilitate our understanding of their importance in insects’ chemical communication. In this study, three OBP genes were cloned and named GmolOBP4, GmolOBP5, and GmolOBP10. Quantitative real‐time PCR results indicated that GmolOBP4 and GmolOBP10 were predominantly expressed in adult antennae and GmolOBP5 was expressed in multiple tissues, including head, legs, and wings in addition to antennae. The binding affinities of the three recombinant GmolOBPs (rGmolOBPs) with four sex pheromone components and twenty‐nine host plant volatiles were measured using 1‐N‐Phenyl‐naphthylamine as a fluorescence probe. The three rGmolOBPs exhibited specific binding properties to potential ligands, GmolOBP4 and GmolOBP10 bound to minor sex pheromone components, such as (Z)‐8‐dodecenyl alcohol and dodecanol, respectively. rGmolOBP4 showed intermediate binding ability with hexanal, benzyl alcohol, and pear ester, rGmolOBP5 had a weak affinity for benzaldehyde, pear ester and, methyl jasmonate, and rGmolOBP10 showed strong binding capacity toward hexanol, decanol, and α‐ocimene. We speculate that the GmolOBP4 and GmolOBP10 have dual functions in perception and recognition of host plant volatiles and sex pheromone components, while GmolOBP5 may serve other function(s).
Maintenance of redox balance by antioxidants in hemolymph of the greater wax moth Galleria mellonella larvae during encapsulation response
Authors: Grizanova Ekaterina V. , Semenova Alexandra D. , Komarov Denis A. , Chertkova Ekaterina A. , Slepneva Irina A. , Dubovskiy Ivan M. 
Published: March 2018

AbstractThe lipid peroxidation process in hemocytes, activities of phenoloxidase and key enzymatic antioxidants (superoxide dismutase, glutathione‐S‐transferase, catalase) and nonenzymatic antioxidants (thiols, ascorbate) in hemolymph of the greater wax moth Galleria mellonella L. (Lepidoptera: Pyralidae) were studied during the encapsulation process of nylon implants. It has been established that as soon as 15 min after piercing a cuticle with the implant, a capsule is formed on its surface. Active melanization of the capsule has been shown to last for 4 h. During the first hours after incorporating the implant, an increase in phenoloxidase activity and lipid peroxidation in the insect hemocytes has been revealed. Adhesion and degranulation on the surface of foreign object lead to the depletion of total hemocytes count (THC). Our results indicated that thiols and ascorbate molecules take part in the immediate antioxidant response, during later stages of encapsulation process hemolymph glutathione‐S‐transferase detoxifies and protects insect organism thereby restoring the internal redox balance. We suggest that nonenzymatic and enzymatic antioxidants of hemolymph plasma play a key role in the maintenance of redox balance during encapsulation of foreign targets.
Cloning, expression profiling, and acetylation identification of alpha‐tubulin N‐acetyltransferase 1 from Bombyx mori
Authors: Zhou Huaixiang , Cheng Xusheng , Xu Xiaoyuan , Jiang Tianlong , Zhou Haimeng , Sheng Qing , Nie Zuoming 
Published: March 2018

AbstractAlpha‐tubulin N‐acetyltransferase 1 (ATAT1) is an acetyltransferase specific to α‐tubulin and performs important functions in many cellular processes. Bombyx mori is an economic insect and also known as a model lepidoptera insect. In this study, we cloned a B. mori ATAT1 gene (BmATAT1) (Gen Bank accession number: XP_004932777.1). BmATAT1 contained an open reading frame (ORF) of 1,065 bp encoding 355 amino acids (aa). Expression profiling of BmATAT1 protein showed that the expression levels of BmATAT1 at different developmental stages and different tissues in fifth‐instar larvae differ. BmATAT1 was highly expressed at the egg stage and in the head of the fifth‐instar larvae. Subcellular localization showed that BmATAT1 was distributed in the cytoplasm and nucleus. Furthermore, BmATAT1 may lead to time‐dependent induction of cell cycle arrest in the G2/M phase by flow cytometry analysis. Interestingly, using site‐specific mutation, immunoprecipitation, and Western blotting, we further found a BmATAT1 acetylated site at K156, suggesting that this acetyltransferase could be regulated by acetylation itself.
Interleukin‐25 Axis Is Involved in the Pathogenesis of Human Primary and Experimental Murine Sjögren's Syndrome
Authors: Guggino Giuliana , Lin Xiang , Rizzo Aroldo , Xiao Fan , Saieva Laura , Raimondo Stefania , Di Liberto Diana , Candore Giuseppina , Ruscitti Piero , Cipriani Paola , Giacomelli Roberto , Dieli Francesco , Alessandro Riccardo , Triolo Giovanni , Lu Liwei , Ciccia Francesco 
Published: March 2018

ObjectiveTo investigate the role of the interleukin‐25 (IL‐25)/IL‐17 receptor B (IL‐17RB) axis in experimental Sjögren's syndrome (SS) and in patients with primary SS and primary SS–associated lymphoma.MethodsExpression of IL‐25, IL‐17RB, IL‐17B, and tumor necrosis factor receptor–associated factor 6 (TRAF6) was analyzed on minor salivary gland (SG) samples from patients with primary SS and on parotid gland samples from patients with primary SS–associated B cell non‐Hodgkin's lymphoma (NHL). IL‐17RB expression and the frequencies of natural group 2 innate lymphoid cells (ILC2s), inflammatory ILC2s, and M2‐polarized macrophages were assessed by flow cytometry in SG mononuclear cells and peripheral blood mononuclear cells (PBMCs). Tissue distribution of ILC2s was studied by confocal microscopy. The role of recombinant IL‐25 and of rituximab in modulating IL‐25 expression was investigated in in vitro studies. IL‐25/IL‐17RB and TRAF6 expression and the role of IL‐25 inhibition were also studied in the experimental murine model of SS.ResultsActivation of the IL‐25/IL‐17RB/TRAF6 axis correlated with the focus score and was observed in patients with primary SS and in patients with primary SS–associated NHL. A significant increase in the frequency of inflammatory ILC2s was observed both in SG mononuclear cells and in PBMCs. IL‐25 stimulation of isolated SG mononuclear cells and PBMCs from patients and controls resulted both in inflammatory ILC2 expansion and in increased autoantibody production. Rituximab modulated expression of inflammatory ILC2s and IL‐25 in primary SS. SG protein–immunized mice developed overt SS symptoms with increased IL‐25 expression and increased frequency of CD4+IL‐17RB+TRAF6+ cells. IL‐25 neutralization attenuated disease progression and tissue pathology in mice with experimental SS.ConclusionIL‐25 may promote the inflammatory state in primary SS and may be a potential target for novel disease‐modifying therapeutic strategies in patients with primary SS.
Abuse Characteristics, Multiple Victimisation and Resilience among Young Adult Males with Histories of Childhood Sexual Abuse
Authors: Ressel Madelaine , Lyons Jennifer , Romano Elisa 
Published: March 2018

Although researchers now concede that one in six men experiences childhood sexual abuse (CSA), this population remains understudied in both the empirical and clinical literature. Little is known about the characteristics of males' CSA experiences (e.g. duration, child‐perpetrator relationship) and about resilient functioning. This study described young adult males' abuse experiences during childhood and their current adaptive functioning. Participants were recruited from across North America through websites geared specifically for males with CSA histories. The sample included 46 males aged 17–25 years who anonymously completed an online questionnaire. Findings indicated that males tended to experience severe CSA, including early age of onset, invasive sexual acts and the use of perpetrator force. Males also reported the co‐occurrence of other forms of childhood maltreatment and adversity, including parental conflict, neglect, physical abuse and emotional maltreatment. Finally, males reported lower rates of resilience on standardised measures, compared with adult community samples in North America. However, scores were consistent with clinical age‐based norms for adolescents with trauma histories. This study contributes to the growing awareness of male CSA, multiple victimisation and its diverse outcomes. Implications of these findings for future research and clinical practice are considered. Copyright © 2018 John Wiley & Sons, Ltd.‘Contributes to the growing awareness of male CSA, multiple victimisation and its diverse outcomes’Key Practitioner Messages

The experiences of CSA among males were found to be severe and to occur alongside other forms of victimisation and adversity.
Males with CSA histories experienced difficulties in their adaptation, in terms of coping with stress and functioning across work, school and interpersonal spheres.
It is important that practitioners consider the serious impact of male CSA across multiple areas of functioning and inquire about other forms of victimisation when working with this population.
TRPC1/3/6 inhibition attenuates the TGF‐β1‐induced epithelial–mesenchymal transition in gastric cancer via the Ras/Raf1/ERK signaling pathway
Authors: Ge Pengbo , Wei Linting , Zhang Mingkai , Hu Baoguang , Wang Kai , Li Yanbin , Liu Shuaichen , Wang Jianping , Li Yuming 
Published: March 2018

AbstractGastric cancer (GC) is one of the most common malignancies worldwide. TGF‐β1 induces the epithelial–mesenchymal transition (EMT) in GC, mainly through Smad‐dependent pathways. Nevertheless, few studies have focused on the activation of non‐canonical transduction pathways. TRPC, Ca2+ entry channels, are ubiquitously expressed in various cell types and are involved in many cellular functions. However, their roles in GC are not well elucidated. This study aimed to determine whether TRPC participates in the TGF‐β1‐induced EMT of GC and to investigate the potential mechanisms. Immunofluorescence staining was performed to examine the distribution and expression of TRPCs and EMT‐related proteins in SGC‐7901 cells incubated with or without TGF‐β1. The expression of TRPC1/3/6 and EMT‐related molecules, including E‐cadherin, vimentin, and α‐SMA, was detected by qRT‐PCR and Western blotting. Additionally, the underlying mechanism was determined by treating cells with pharmacological inhibitors and examining the levels of proteins involved in the main signaling cascades using Western blotting. TRPC1/3/6 were expressed at high levels in SGC‐7901 cells. Following TGF‐β1 stimulation, the expression of vimentin, α‐SMA, and TRPC1/3/6 increased and E‐cadherin expression decreased, accompanied by activation of the Ras/Raf1/ERK1/2 signaling pathway. Notably, activation of the Ras/Raf1/ERK1/2 signaling cascade was suppressed by SKF96365 and 2‐APB. Both TRPC and ERK inhibitors mitigated EMT progression. Based on these results, TRPC1/3/6 inhibition attenuated the TGF‐β1‐induced EMT in GC by suppressing Ras/Raf1/ERK signal transduction.
Propofol prevents IL‐13‐induced epithelial–mesenchymal transition in human colorectal cancer cells
Authors: Xu Kejia , Tao Weimin , Su Zhe 
Published: March 2018

AbstractAccumulating evidence showed that cytokines are involved in the development of cancer. IL‐13 was showed to induce epithelial–mesenchymal transition and promote metastasis in colorectal cancer, providing a promising therapeutic target for cancer patients. Interestingly, recent studies showed that propofol, one of most common intravenous anesthetic agent, may have antitumor function in different cancer type. However, the impact of propofol on colorectal cancer and IL‐13 induced epithelial–mesenchymal transition remains unknown. Herein, we found that propofol can effectively suppress cell proliferation in colorectal cell lines RKO and SW480 cells by using MTT assay. Furthermore, wound healing assay and migration assay demonstrated that propofol has the ability to inhibit epithelial–mesenchymal transition that induced by IL‐13 in RKO and SW480 cells. Mechanistically, we found propofol treatment causes up‐regulation of miR‐361 and miR‐135b, that suppress expression of STAT6 and thereafter leads to the inhibition of IL‐13/STAT6/ZEB1 signaling pathway. In conclusion, our data for the first time demonstrated that propofol may serve as a novel therapeutic drug for targeting IL‐13. The aggressive function of IL‐13/STAT6/ZEB1 axis in colorectal cancer was impaired by propofol through miR‐361 and miR‐135b.
Improving Physical Adsorption of CO2 by Ionic Liquids‐Loaded Mesoporous Silica
Authors: Mirzaei Mojtaba , Mokhtarani Babak , Badiei Alireza , Sharifi Ali 
Published: March 2018

AbstractCO2 sorption capacities of the neat and silica‐supported 1‐butyl‐3‐methylimidazolium‐based ionic liquids (ILs) were measured under atmospheric pressure. The silica‐supported ILs were synthesized by the impregnation‐vaporization method and charactrized by N2 adsorption/desorption and thermogravimeteric analysis (TGA). Evaluation of the effects of influential factors on sorption capacity demonstrated that by increase of the temperature, flow rate, and the weight percentage of ILs in sorbents, the sorption capacity decreases. Among the sorbents, [Bmim][TfO] and SiO2‐[Bmim][BF4](50) had the highest capacity. By increasing the IL portion in SiO2‐[Bmim][BF4], the selectivity for CO2 to CH4 could be improved. The CO2‐rich sorbents could be easily recycled.
Structuring of Batch Mixer Loading to Improve Mixing Time and Mixture Quality of Solids
Authors: Mizonov Vadim , Balagurov Ivan , Berthiaux Henri , Gatumel Cendrine 
Published: March 2018

AbstractA simple yet informative model was built to estimate the influence of the initial distribution of dissimilar particulate solids to be mixed on the mixing time and mixture quality, and a way was searched to reduce the negative influence of segregation on the mixing process. The influence of segregation is particularly strong when it is necessary to mix a small amount of a key component with a large amount of a basic one. It is shown that the mixing time and mixture quality can be noticeably improved by introducing a premixing stage that consists in loading the key component in layers distributed over the basic component. A possible technical solution for such loading is also proposed. Experimental tests of such lab‐scale vibration mixer proved its efficiency.
Metallothermic Reduction of Silica Nanoparticles to Porous Silicon for Drug Delivery Using New and Existing Reductants
Authors: Lai Yiqi , Thompson Jonathan R. , Dasog Mita 
Published: March 2018

AbstractIn this study, the influence of metals (Mg, Al, and Ca) and reaction conditions (time, temperature, and metal grain size) on the metallothermic reduction of Stöber silica nanoparticles (NPs) to form porous Si has been explored. Mg metal was found to be an effective reducing agent even at temperatures below its melting point; however, it also induced a high degree of structural damage and morphology change. Al was effective in reducing silica NPs only at its melting point or above, but the resulting particles retained a higher degree of structural morphology as compared to those reduced using Mg. Ca was found to be ineffective in reducing silica. A new reductant, a mixture of 70 % Mg and 30 % Al, was found to induce the least amount of morphology change, and the reactions proceeded at a temperature (450 °C) lower than those required with Mg or Al individually. Furthermore, porous Si NPs obtained using Mg, Al, and the mixture of 70 % Mg and 30 % Al as reductants have been investigated as carriers for ibuprofen loading and release. Porous Si obtained from reductions with Mg and the Mg/Al mixture showed higher drug loading and a sustained drug release profile, whereas porous Si obtained from Al reduction had lower loading and showed a conventional release profile over 24 h.
Synthesis and Self‐Assembly of Bay‐Substituted Perylene Diimide Gemini‐Type Surfactants as Off‐On Fluorescent Probes for Lipid Bilayers
Authors: Schill Jurgen , van Dun Sam , Pouderoijen Maarten J. , Janssen Henk M. , Milroy Lech‐Gustav , Schenning Albertus P. H. J. , Brunsveld Luc 
Published: March 2018

AbstractInterest in bay‐substituted perylene‐3,4:9,10‐tetracarboxylic diimides (PDIs) for solution‐based applications is growing due to their improved solubility and altered optical and electronic properties compared to unsubstituted PDIs. Synthetic routes to 1,12‐bay‐substituted PDIs have been very demanding due to issues with steric hindrance and poor regioselectivity. Here we report a simple one‐step regioselective and high yielding synthesis of a 1,12‐dihydroxylated PDI derivative that can subsequently be alkylated in a straightforward fashion to produce nonplanar 1,12‐dialkoxy PDIs. These PDIs show a large Stokes shift, which is specifically useful for bioimaging applications. A particular cationic PDI gemini‐type surfactant has been developed that forms nonfluorescent self‐assembled particles in water (“off state”), which exerts a high fluorescence upon incorporation into lipophilic bilayers (“on state”). Therefore, this probe is appealing as a highly sensitive fluorescent labelling marker with a low background signal for imaging artificial and cellular membranes.
Enantioselective resolution of Rac‐terbutaline and evaluation of optically pure R‐terbutaline hydrochloride as an efficient anti‐asthmatic drug
Authors: Beng Huimin , Zhang Hao , Jayachandra R. , Li Junxiao , Wu Jie , Tan Wen 
Published: March 2018

AbstractTerbutaline is a β2‐adrenoceptor agonist for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Among the two isomers of terbutaline (TBT 2), R‐isomer was found to be the potent enantiomer in generating therapeutic effect, while S‐isomer has been reported to show side effects. In this study, R‐terbutaline hydrochloride (R‐TBH 6) was synthesized through chiral resolution from the racemic terbutaline sulfate (rac‐TBS 1) with 99.9% enantiomeric excess (ee) in good overall yield (53.6%). Further, R‐TBH 6 nebulized solution was prepared in half dosage of Bricanyl®, which is a marketed product of racemic terbutaline and evaluated in vitro aerosol performance and in vivo anti‐asthmatic effect on guinea pigs via. pulmonary delivery. From the investigation, it is evident that R‐TBH 6 nebulized solution of half dosage performed similar fine aerosol characteristics and anti‐asthmatic effect with Bricanyl®.
Using triangles and latent factor cosine similarity prior to improve community detection in multi‐relational social networks
Authors: Zhan Jianzhou , Sun Mei , Wu Huidan , Sun Haojun 
Published: March 2018

SummaryCommunity detection is a key to understanding the structure of complex networks. Communities, or clusters, are groups of vertices having higher probability of being connected to each other than to the members in other groups. Considering the importance of triangle structures, we first propose σ‐tensor to model ordinary relationships and triangle relationships simultaneously. Then, we propose a simple but effective latent factor prior, ie, latent factor cosine similarity prior, to improve community detection. The latent factor cosine similarity prior is a kind of statistics of the well‐defined synthetic multi‐relational social networks. It is based on a key observation that most latent feature factors of intra‐group members in these networks are highly similar according to cosine similarity measure. Using this prior along with the RESCAL tensor factorization model, we can obtain a superior latent feature factor matrix. Moreover, N‐RESCAL model, a variant of RESCAL model, and its corresponding algorithm N‐RESCAL‐ALS are proposed for the simplicity and the removal of the limit of cosine similarity. Once the latent factor matrix is obtained by factorizing σ‐tensor using N‐RESCAL model, we apply agglomerative clustering algorithm for community discovery. We call this framework as TNRA. Experiment results on several real‐world datasets are surprisingly promising, clearly demonstrating the power of the proposed prior and the effectiveness of our proposed methods.
CCN: A novel energy efficient greedy routing protocol for green computing
Authors: Siddiqa Ayesha , Qureshi Faisal Fayyaz , Shah Munam Ali , Iqbal Rahat , Wahid Abdul , Chang Victor 
Published: March 2018

SummaryWe proposed a novel Energy Efficient Greedy Routing Protocol (EEGRP) in CCN for MANETs to achieve the gaps in the existing infrastructure of Green Cloud Computing. Initially, the consumer node broadcasts the interest packet; each relay node verifies if it is already satisfied, and then it drops the packet. Otherwise, the provider node selects shortest path to unicast data packet within minimum delay. Each relay node receives a data packet, stores its content in content store, and forwards it to next node according to path mention in the hop‐count field. If the data packet custodian node does not find path mention in the hop‐count field, then it searches the routing table entries to choose the second best path to unicast the data packet. EEGRP is implemented in three scenarios using ns2 and compare its performance with AIRDrop routing protocol on bases of three performance parameters like packet delivery ratio, delay, and energy consumption. EEGRP achieves high PDR with minimum delay and less energy consumption as compared to AIRDrop. Therefore, EEGRP is feasible to use on green computing and cloud technology. This can save energy issue to secure energy for Green Computing and Cloud before moving to full‐scale virtualization and Cloud services.