bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can a subgroup at high risk for LRR be identified from T1-2 breast cancer with negative lymph nodes after mastectomy? A meta-analysis
Authors: Peng Gongling , Zhou Zhuohui , Jiang Ming , Yang Fan 
Published: September 2019

Abstract
Purpose: To identify a subgroup at high risk for loco-regional recurrence (LRR) from T1-2 breast cancer with negative lymph nodes (N0) after mastectomy by using a meta-analysis.
Methods and materials: Published studies on the relationship between clinical features and LRR of breast cancer were identified from public databases, including PubMed, EMBASE, and the Cochrane Library. High-risk features for LRR in this patient population were defined based on the pooled results of meta-analysis.
Results: For the meta-analysis, a total of 11244 breast cancers with pT1-2N0 after mastectomy from 20 publications were included for analysis. The pooled results indicated that age (hazard ratio (HR) 1.77, P=0.001), lymphovascular invasion (LVI) (HR 2.23, P&lt;0.001), histologic grade (HR 1.66, P&lt;0.001), HER2 status (HR 1.65, P=0.027), menopausal status (HR 1.36, P=0.015), and surgical margins (HR 2.56, P=0.014) were associated with a significantly increased risk of developing LRR in this patient population group, but not for tumor size (HR 1.32, P=0.23), systematic therapy (HR 1.67, P=0.20), and hormonal receptor status (HR 1.04, P=0.73).
Conclusion: In the current study, patients with young age, positive LVI, high histologic grade, HER-2 positive, premenopausal, and positive surgical margins have an increased risk of developing LRR. Further prospective trials are needed to clearly define the role of adjuvant postmastectomy radiotherapy in T1-2N0 breast cancer at high risk of developing LRR.
Mesenchymal stem cells significantly improved treatment effects of Linezolid on severe pneumonia in a rabbit model
Authors: Kong Dexiao , Liu Xia , Li Xiaomei , Hu Jianting , Li Xiaoyan , Xiao Juan , Dai Yibo , He Mingming , Liu Xiaoli , Jiang Yang , Cui Ruodi , Zhang Lihong , Wang Juandong , Li Ai , Wang Fang , Zhang Yuan , Xiao Juan , Wang Wei , Zheng Chengyun 
Published: September 2019

Abstract
The present study aimed to investigate whether co-administration of mesenchymal stromal cells (MSC) and linezolid (LZD) into a rabbit model of methicillin-resistant Staphylococcus aureus (MRSA)-infected pneumonia would bring a synergistic therapeutic effect. Human umbilical cord-derived MSCs (hUMSCs) were isolated and characterized. A rabbit model of pneumonia was constructed by delivering 1 × 1010 CFU MRSA via a bronchoscope into the basal segment of lower lobe of right lung. Through analyzing vital sign, pulmonary auscultation, SpO2, chest imaging, bronchoscopic manifestations, pathology, neutrophil percentage, and inflammatory factors, we verified that a rabbit model of MRSA-induced pneumonia was successfully constructed. Individual treatment with LZD (50 mg/kg for two times/day) resulted in improvement of body weight, chest imaging, bronchoscopic manifestations, histological parameters, and IL-10 concentration in plasma (P&lt;0.01), decreasing pulmonary auscultation, and reduction of IL-8, IL-6, CRP, and TNF-α concentrations in plasma (P&lt;0.01) compared with the pneumonia model group at 48 and 168 h. Compared with LZD group, co-administration of hUMSCs (1 × 106/kg for two times at 6 and 72 h after MRSA instillation) and LZD further increased the body weight (P&lt;0.05). The changes we observed from chest imaging, bronchoscopic manifestations and pathology revealed that co-administration of hUMSCs and LZD reduced lung inflammation more significantly than that of LZD group. The plasma levels of IL-8, IL-6, CRP, and TNF-α in combined group decreased dramatically compared with the LZD group (P&lt;0.05). In conclusion, hUMSCs administration significantly improved therapeutic effects of LZD on pneumonia resulted from MRSA infection in a rabbit model.
Mechanism of anti-dementia effects of mangiferin in a senescence accelerated mouse (SAMP8) model
Authors: Du Zhengcai , Fanshi Fangcao , Lai Yu-Heng , Chen Jung-Ren , Hao Erwei , Deng Jiagang , Hsiao Chung-Der 
Published: September 2019

Abstract
Mangiferin (2-β-d-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one), a xanthanoid, is one of the major compounds isolated from mango leaves and bark fruit. Previous studies have identified several properties of mangiferin, such as preventing microbial growth, reducing oxidative stress and helping reduce risk of diabetes. The aim of the present study is to explore the potential anti-dementia effects of Mangiferin in a senescence-accelerated mouse prone 8 (SAMP8) mouse model. Morris water maze (MWM) test showed that mangiferin significantly improved the learning and memory retention in SAMP8 mice. In addition, mangiferin reduced the damage in hippocampal neurons and mitochondria, and decreased the expression of amyloid-β (Aβ1-40 and Aβ1-42); however, no influence on the expression of amyloid precursor protein (APP) within the brain of SAMP8 mice. Moreover, Mangiferin inhibited lipid peroxidation (LPO). In conclusion, we provided evidences to show that mangiferin significantly restored the learning and memory impairment in the SAMP8 mouse model, and reduced the pathological injury in hippocampal by modulating lipid oxidation and amyloid-β deposition in the brain.
Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα
Authors: Ivanova Iglika G. , Perkins Neil D. 
Published: September 2019

AbstractThe nuclear factor-κB (NF-κB) family of transcription factors can directly or indirectly regulate many important areas of biology, including immunity, inflammation and cell survival. One intriguing aspect of NF-κB crosstalk with other cell signalling pathways is its regulation of mitochondrial biology, including biogenesis, metabolism and apoptosis. In addition to regulating the expression of mitochondrial genes encoded in the nucleus, NF-κB signalling components are also found within mitochondria themselves and associated with mitochondrial DNA. However, complete biochemical analysis of mitochondrial and sub-mitochondrial localisation of all NF-κB subunits has not been undertaken. Here, we show that only the RelA NF-κB subunit and its inhibitor IκBα reside within mitochondria, whilst p50 is found in the endoplasmic reticulum (ER). Fractionation of mitochondria revealed that only RelA was found in the mitoplast, the location of the mtDNA. We demonstrate that hypoxia leads to a very rapid but transient accumulation of RelA and IκBα in mitochondria. This effect required reactive oxygen species (ROS) but was not dependent on the hypoxia sensing transcription factor subunit HIF1α or intracellular Ca2+ release. We also observed rapid mitochondrial localisation of transcription factor STAT3 following hypoxia. Inhibition of STAT3 blocked RelA and IκBα mitochondrial localisation revealing a previously unknown aspect of crosstalk between these key cellular regulators.
Today's Graduate Students, Tomorrow's SLPs: Enhancing School Practicum Experiences
Authors: Marante Leesa , Hall-Mills Shannon 
Published: September 2019

Purpose
In this article, we describe a standards-driven, workforce-focused model of school practicum offered by an accredited graduate speech-language pathology program.

Method
To prepare more than 50% of the American Speech-Language-Hearing Association's membership for the school-based workforce, graduate students require real-life practicum experiences in the schools. Practicum experiences should be standards driven, anchored in the graduate curriculum, and paired with academic coursework to foster the growth of student clinicians' background knowledge prior to engagement in a school-based practicum.

Results
We outline the main content areas and minimum practice experiences that should be incorporated in a school-based practicum and provide suggestions for balancing the requirements across the graduate curriculum. Collaboration with school systems is essential for locating and maintaining high-quality placements.

Conclusion
School practicum experiences provide an important foundation for future school speech-language pathologists to enter the workforce with adequate preparation.
Tinnitus and the Brain: A Review of Functional and Anatomical Magnetic Resonance Imaging Studies
Authors: Shahsavarani Somayeh , Khan Rafay Ali , Husain Fatima Tazeena 
Published: September 2019

Purpose
The tinnitus patient population is inherently heterogeneous. Although tinnitus often co-occurs with hearing loss and is more frequent among elderly people, it affects all age groups with varying hearing sensitivity. In addition, tinnitus severity and patients' reaction to tinnitus vary across individuals. Regardless of the metrics used to measure tinnitus handicap, on one end of the severity spectrum are the patients who have managed to habituate to their tinnitus; at the other end are those who are extremely bothered by tinnitus, and often have a confluence of related comorbidities of mood disorders. Understanding the neural correlates of tinnitus while accounting for such variations could benefit clinicians, helping them modify and objectively monitor tinnitus management strategies. Brain imaging, specifically magnetic resonance imaging, is an excellent tool to study the functional and structural properties of the neural networks involved in tinnitus and tinnitus severity.

Method
In this article, we review studies that employ magnetic resonance imaging-based neuroimaging techniques including resting-state functional connectivity, voxel-based morphometry, and diffusion tensor imaging to investigate underlying functional and structural neural correlates of tinnitus to address overarching dimensions of a person's reaction to tinnitus, namely, audition, emotion, and attention.

Results
We discuss findings from brain imaging studies in the context of theories and models proposed for tinnitus generation and persistence.

Conclusion
These studies have revealed tinnitus-related alteration in the auditory, emotion, and attention neural networks. Future research is required to better understand these changes in the neural circuitry based on tinnitus comorbidities and severity, and to refine existing theoretical models.
„Jetzt ist der Mensch noch nicht jener Mensch“ – Nachdenken über eine
Verhältnisprävention der Adipositas
Authors: Müller Manfred J. 
Published: September 2019

ZusammenfassungAngesichts der Häufigkeit und der begrenzten Erfolge von Verhaltensprävention und
Behandlung erscheint eine Verhältnisprävention der Adipositas notwendig. Die
bisherigen Erfahrungen von tobacco control sprechen für deren mögliche
Wirksamkeit und Übergewicht. Verhältnisprävention adressiert die „Treiber“ von
Lebensstilen; dazu gehören unkontrolliertes ökonomisches Wachstum, soziale
Verhältnisse und Konsumismus. Verhältnisprävention setzt einen breiten
gesellschaftlichen Diskurs voraus; sie ist abhängig von den Prioritäten, welche
wir gemeinsam unter der Berücksichtigung vielfältiger Interessen festlegen.
Verhältnisprävention ist lösungsorientiert und erfordert Konzepte und Strategien
von Public Health anstelle der auf das Paradigma der Energiebilanz und deren
möglichen biologischen Kontrolle fokussierten medizinischen Ansätze von
Verhaltensprävention und Behandlung von Adipositas. Es ist zu vermuten, dass
eine wirksame Verhältnisprävention zukünftig auch die nachhaltigen Erfolge von
Verhaltensprävention und die Therapie der Adipositas verbessert.
The provision and efficacy of peer feedback in blogs versus paper-based writing
Authors: Lira-Gonzales Maria-Lourdes , Nassaji Hossein 
Published: September 2019

Abstract
While the use of blogs has gained increasing popularity among second language (L2) writers, research into their
role in developing L2 writing ability is yet underdeveloped. In particular, investigations into the use and effectiveness of peer
feedback on L2 blogs are limited. The current study sought to fill this gap by comparing the provision of peer feedback in blogs
versus on paper. Participants were a class of ESL students in a TESL university program in Quebec who produced written texts both
in blogs and on paper, received peer feedback, and then revised their texts. Altogether, the findings suggest that while both
blogs and paper can be influential mediums for L2 writing, they may inspire different types of errors, elicit different types and
degrees of feedback, and lead to differences in subsequent revisions.
Sign language interpreting services
Authors: De Meulder Maartje , Haualand Hilde 
Published: September 2019

Abstract

Sign language version of the abstract

This article rethinks the impact of sign language interpreting services (SLIS) as a social institution. It starts
from the observation that “access” for deaf people is tantamount to availability of sign language interpreters, and the often
uncritically proposed and largely accepted solution at the institutional level to lack of access seems to be increasing the number
of interpreters. Using documented examples from education and health care settings, we raise concerns that arise when SLIS become
a prerequisite for public service provision. In doing so, we problematize SLIS as replacing or concealing the need for
language-concordant education and public services. We argue that like any social institution, SLIS should be studied and analyzed
critically. This includes more scrutiny about how different kinds of “accesses” can be implemented without SLIS, and more
awareness of the contextual languaging choices deaf people make beyond the use of interpreters.
Arginine-mediated dissociation of single cells and cell sheets from a polystyrene culture dish
Authors: Ikeda Takeshi , Ichikawa Kohei , Shigeto Hajime , Ishida Takenori , Hirota Ryuichi , Funabashi Hisakage , Kuroda Akio 
Published: September 2019

ABSTRACT
Here, we report a novel non-enzymatic cell dissociation method, based on our finding that adherent cells dissociate rapidly from the polystyrene culture dish when incubated in an l- or d-arginine-containing solution. We also demonstrate the successful detachment of confluent NIH/3T3 cell monolayers from the culture dish as a cell sheet by the addition of an arginine solution.
Investigation into the current loss in InAs/GaAs quantum dot solar cells with Si-doped quantum dots
Authors: Chan Shun , Kim Dongyoung , Tang Mingchu , Li Xiao , Liu Huiyun 
Published: September 2019

Abstract
Our previous studies have shown that introducing Si doping in quantum dots (QDs) can help QD solar cells achieve higher voltage. However, this improvement came at the cost of current loss. In this work, we continue to investigate the cause of the current loss and propose a method to recover it without compromising the voltage. Photoluminescence measurements have confirmed that optimizing the thickness of the GaAs layers in the i-region can lead to strong current gain (~14%) with minimal voltage loss (<3%) and alteration of the QD quality. The capacitance–voltage measurement results support that the current gain mainly originates from the increased depletion width.
Magnetic-impurity-induced modifications to ultrafast carrier dynamics in the ferromagnetic topological insulators Sb2−xVxTe3
Authors: Sumida K , Kakoki M , Reimann J , Nurmamat M , Goto S , Takeda Y , Saitoh Y , Kokh K A , Tereshchenko O E , Güdde J , Höfer U , Kimura A 
Published: September 2019

Abstract
Quantum anomalous Hall effect (QAHE) is a key phenomenon for low power-consumption device applications owing to its dissipationless spin-polarized and quantized current in the absence of an external magnetic field. However, the recorded working temperature of the QAHE is still very low. Here we systematically investigate the magnetic dopants induced modifications from the view points of magnetic, structural and electronic properties and the ultrafast carrier dynamics in a series of V-doped Sb2Te3 samples of composition Sb2−x
V
x
Te3 with x = 0, 0.015 and 0.03. Element specific x-ray magnetic circular dichroism signifies that the ferromagnetism of V-doped Sb2Te3 is governed by the p–d hybridization between the host carrier and the magnetic dopant. Time- and angle-resolved photoemission spectroscopy excited with mid-infrared pulses has revealed that the V impurity induced states underlying the topological surface state (TSS) add scattering channels that significantly shorten the duration of transient surface electrons down to the 100 fs scale. This is in a sharp contrast to the prolonged duration reported for pristine samples though the TSS is located inside the bulk energy gap of the host in either magnetic or non-magnetic cases. It implies the presence of a mobility gap in the bulk energy gap region of the host material that would work toward the robust QAHE. Our findings shed light on the material design for low-energy-consuming device applications.
Studies and applications of magnetic interactions in the system “iron-copper-water”
Authors: Klassen N V , Burova D N , Cebruk I S 
Published: September 2019

Abstract
The recovery of copper by iron in copper sulfate aqueous solutions was studies as a function of the external magnetic field and morphologies of iron containing steel samples. Essential retardation of the recovery by the magnetic field was found as well as decrease of iron sulfate solubility in water induced by the field. The retardation is explained by the active participation of inter-domain walls in the recovery and decreasing of their length in the magnetic field. When steel filings were used for the recovery instead of the volume samples the magnetic retardation was not notices. Applications of these results are developed for new methods of lithography of microschemes and restoration of electrical contact wires.
Laser forming of nanostructures in aqueous suspensions with particular optical and photoelectrical properties
Authors: Vinokurov S E , Klassen N V 
Published: September 2019

Abstract
The self-organizing forming of ordered nanostructures in the aqueous suspensions with inorganic nanoparticles of nickel, copper, silica and bio-organic particles of grinded green leaves were studied by means of the irradiation with red, green and blue lasers. Various forms of self-consistent non-homogeneous distributions of the nanocomponents and the optical flows were found. The suspensions with high density of the nickel nanoparticles demonstrated abrupt changes of their transparency and periodicity. These abrupt changes were transformed to more slow oscillations of the particles and light distributions when the nickel particles were mixed with the nanoparticles of copper. The suspensions with the nanoparticles of copper created arc-like agglomerations explained by generation of vortexes. The vortex-like distributions were found in the suspensions with silica as well. The anisotropic agglomerations were observed during the irradiations of the suspensions with the grinded green leaves. These results are promising for the developments of new kinds of optical modulators and switchers, optical memory and green solar batteries.
Formation of vortex turbulence by a heat current in superfluid helium in a long capillary
Authors: Orlova A A , Efimov V B 
Published: September 2019

Abstract
The propagation of long pulses of the second sound in superfluid helium was experimentally studied. The results of the experiments showed that at the propagation of heat currents of sufficiently high power the process of formation a vortex tangle begins near the heater. It leads to significantly reducing the counterflow of the normal and the superfluid components in helium and, consequently, thermal conductivity of superfluid helium.
An Interference of P-waves from Weakly Conducting and Transparent Dielectric Films
Authors: Yushkanov A A , Zverev N V 
Published: September 2019

Abstract
An influence of kinetic and quantum properties of non-degenerate electron plasma on the interference of P-waves from films of the similar thickness made of weakly conducting substance and of transparent dielectric one, is investigated numerically. The reflection and transmission coefficients of interfering P-waves as well as their phase differences are studied. It is found that for the frequencies of the order of plasma frequency in case of small film thicknesses, the results for quantum non-degenerate electron plasma differ from the ones for classical non-degenerate electron plasma and for classical electron gas. Here one observes a temperature dependence of the values in the cases of quantum and classical non-degenerate electron plasma.
Thermal conductivity performance of nanoporous plate for high-power LED lighting and power electronics
Authors: Kurilov A D , Belyaev V V , Nessemon K D , Besprozvannyi E D , Osin A O , Tokareva O A , Skvortsov A Y 
Published: September 2019

Abstract
Comparative results of measurements of the thermal resistance of a new nanoporous material based on aluminium oxide are presented. Low-cost high-heat-conducting printed circuit boards for high-power LEDs, LED lighting devices and power electronics on the basis of the presented material have been developed and manufactured. Comparison of a set of performances of nanoporous aliminium oxide and aluminium nitride ceramics demonstrate advantages of the material developed. Its thermal characteristics is inferior to the AlN ceramics by 30%, but the cost of the proposed material is lower by almost four times.
Comparative analysis of application of wavelet analysis for the recognition of element composition nanostructures
Authors: Tkachenko I M , Kozhanova E R , Belyaev V V , Yazbeck H 
Published: September 2019

Abstract
The paper presents a technique for applying a wavelet analysis (continuous and discrete wavelet transforms) to analyze the elemental composition of nanostructures in order to identify the chemical composition. The experimental data were obtained by means of a scanning electron microscope. The acquisition, processing and study of spectra were carried out using the author’s software product “labpraktikum_osnov_wavelet”.
Influence of nano-objects positioning on sensitivity of QCM sensor
Authors: Novichkova P O , Vechkanov A R , Yanovitch S V 
Published: September 2019

Abstract
Dependence of the sensitivity of the QCM sensor on the position of the object relative to the centre of the sensor is considered. Comparison of calculating mass increment and measured values in cases of various fillings and displacement of nanoobjects was carried out.
Effectivity of water hyacinth (Eichhornia crassipes (Mart.) Solms) as bio filter for microbiological water quality in Purwomartani Housing, Kalasan, Sleman, DIY
Authors: Kahol Y V , Ningrum N S , Retnaningrum E , Darmasiwi S 
Published: September 2019

Abstract
Water is one of the most important needs for organisms. However, microbial contamination in water has become serious issue recently. We were interested to reduce the microbial contamination in water by using biological agents such as water hyacinth. In some studies, water hyacinth has antimicrobial activities as well as their function as phytoremediation agent. This research was done to study the effectiveness of water hyacinth (Eichhornia crassipes (Mart.) Solms as bio filter against coliform in water of Mataram water channel in Yogyakarta. The bio filter were arranged as following layer; gravel, zeolite and water hyacinth as the most upper part of bio filter. It was then set with the direction along with the river flow. The water samples were then taken triplicates, each from the upstream (before bio filter treatment) and downstream (after bio filter treatment). It were then continued by Most Probable Number (MPN) test which include the presumptive, confirmed, and completed test. The MPN results showed that coliform in the upstream were found about 57.34 ± 54.35 MPN / 100 ml while in the downstream were about 808 ± 678.96 MPN / 100 ml. The statistical test showed that the difference between upstream and downstream were not significant. Thus it can be concluded that water hyacinth bio filter was not effectively used as bio filter against coliform bacteria.