bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Pivotal Role of Immune Functional Assays in Deciphering Immune Function Alterations
Authors: Debombourg Marion , Oriol Guy , Dupre Caroline , Albert-Vega Chloé , Venet Fabienne , Rimmelé Thomas ,   REALISM study group, Conrad Anne , Ader Florence , Alcazer Vincent ,   VaccHemInf study group, Brengel-Pesce Karen , Fleurie Aurore , Trouillet-Assant Sophie , Mouton William 
Published: November 2024

1AbstractRecently, immune function assessment has gained prominence in clinical settings. Immune functional assays (IFAs), involving in vitro stimulation, offer a relevant approach to complement traditional immunomonitoring methods which, while widely used, do not fully capture functional immune capabilities. Despite growing interest in IFAs, their added value remains unclear.To address this gap, our study aimed to determine if insights from IFAs could be replicated with unstimulated immunoprofiling. Using the same analytical pipeline, we compared transcriptomic profiles (Nanostring®) between stimulated (TruCulture®) and unstimulated (PaxGene™) samples from i) patients with an overstimulated immune system 3-4 days post-sepsis onset, and ii) patients undergoing immune reconstitution 6-months post-allogeneic hematopoietic stem cell transplantation (allo-HSCT).In sepsis, post-stimulation transcriptomic profiles revealed immune clusters linked to disease severity and outcomes, surpassing traditional markers like mHLA-DR, while baseline analyses failed to generate clinically relevant stratification. Similarly, allo-HSCT patients’ post-stimulation data revealed immune heterogeneity and treatment-related alterations not detected using baseline transcriptomic or cellular profiles alone.Our findings emphasize the value of IFAs in uncovering functional immune alterations that unstimulated assessments may miss, which could offer deeper insights into immune dysfunction. This study supports IFAs as complementary tools to current clinical practices, enhancing patient management with a functional view of immune system dynamics.
Life beyond childhood: insight into the lived experience of 91 adults with KBG syndrome through an online patient/caregiver reported co-produced questionnaire
Authors: Low KJ , Walker M , Treneman-Evans G , Bramswig NC , Herlin MK , Lesca G , Scarano E , Ockeloen CW , Bayat A 
Published: November 2024

AbstractPurposeKBG syndrome (KBGS) is a rare neurodevelopmental syndrome. We aimed to study the impact of KBGS in adulthood as reported by individuals with KBGS and their families/caregivers, thereby exploring aspects of everyday life under-reported by healthcare professionals.MethodsWe co-produced an online questionnaire for adults with KBGS and their families/caregivers. Participants were recruited via the KBG foundation, an American-based charity supporting individuals with KBGS and their families worldwide, and other international collaborators.ResultsThere were 91 responses for analysis, across the age range of 16-86 years. Respondents described a range of living arrangements, education, employment, leisure activities and relationships. A higher proportion of 45-54year olds had achieved independent living skills such as driving and grocery shopping compared to the younger age groups. None of the participants who were experiencing seizures lived independently. We described high rates of psychiatric comorbidities, behavioural difficulties, sleep problems, seizures, visual and hearing problems, dental and skeletal issues, and a higher than expected cardiovascular and gastrointestinal burden of disease.ConclusionThis study provides new insights into the everyday life of adults with KBGS, along with high rates of comorbidities which continue to impact on quality of life into adulthood, with implications for medical care.
Role of transformational leadership in implementation of Education 4.0: a parallel mediation model in context of higher educational institutions (HEIs)
Authors: Sharma Rajesh Kumar , Kaur Sukhpreet , Mittal Amit 
Published: November 2024

Purpose
Transformational leadership has attained immense attraction in contemporary research for its positive contribution in implementation of Education 4.0. Drawing on social bond theory and employee stewardship theory, this study aims to examine the mediating roles of employee engagement and organisational citizenship behaviour between transformational leadership and Education 4.0 in higher educational institutions.

Design/methodology/approach
Data was collected through survey questionnaire by using three-wave time lagged study design from regular faculty members of Indian higher educational institutions. Hayes Process Macro was used for testing the parallel mediation model.

Findings
Transformational leadership has a positive and significant impact on Education 4.0. The results of this study indicate that employee engagement and organisational citizenship behaviour partially mediate the relationship between transformational leadership and Education 4.0. Furthermore, the analysis explains that employee engagement and organisational citizenship behaviour leveraged under transformational leadership act as parallel mediators, and there is no statistical difference between them.

Originality/value
To the best of the authors’ knowledge, this study is first in itself to consider more than one factor influencing the relationship between transformational leadership and Education 4.0, thus making ground for parallel mediation. This study addresses the urgent call by United Nations for achieving Sustainable Development Goals (SDGs) by ensuring quality education (SDG 4) and reducing inequality (SDG 10), thereby giving peaceful and strong intuitions (SDG 16).
Big data analysis of Spanish wine consumers reviews
Authors: Calderon-Monge Esther , Ripollés-Matallana Vicente , Baruque-Zanón Bruno , Porras Alfonso Santiago 
Published: November 2024

Purpose
Wine is a complicated and difficult product to know, which makes it extremely difficult for people with little knowledge to choose the wine they want. This study aims to analyze whether the vocabulary used in reviews on wine written by experts and amateurs on the specialized website is useful for those consumers who wish to search for information on this website to choose a wine.

Design/methodology/approach
The analysis combines text mining, Natural Language Processing and the Biterm Topic model applied to 25,847 reviews, evaluating a total of 13,263 Spanish wines made by 17 selected users of a specialized wine website.

Findings
The results show that wine consumers and users of the specialized wine website who write reviews can be divided into expert users and amateur users. Both experts and amateurs use a specific vocabulary related to the wines they review. Unlike amateurs, experts have a broader and more precise vocabulary, and greater consistency in the use of words with the aspects of the wine. For the revised wines, they address fewer and more specific aspects of wine (such as vintages), but they do so with more depth and rigor.

Originality/value
The originality and value of this research work lie in addressing two aspects that have hardly been analyzed: the reviews of experienced consumers and amateur consumers, and the textual information referring to the Spanish language, which distinguishes this analysis from other similar analyses carried out on the English language.
Unpacking the relationship between formal contracts and alliance innovation performance: the role of relationship learning and guanxi
Authors: Liu Dong , Bao Yongchuan , Wang Guocai 
Published: November 2024

Purpose
The purpose of this study is to examine how formal contracts affect alliance innovation performance. To understand the mechanism underlying the impact, this study tests whether relationship learning mediates the impact of formal contracts on alliance innovation performance and how guanxi moderates the mediating effect.

Design/methodology/approach
This study is conducted with a sample of 225 manufacturers in China. This paper used hierarchical regression analysis to test the hypotheses and used the PROCESS method to test the mediating effect of relationship learning.

Findings
Formal contracts positively affect relationship learning, which facilitates alliance innovation performance. Guanxi positively moderates the effect of formal contracts on alliance innovation performance. Relationship learning mediates the relationship between formal contracts and alliance innovation performance. Moreover, guanxi positively moderates the mediating effect.

Research limitations/implications
Future research could investigate factors moderating the effect of guanxi on alliance innovation performance and moderating the effect of relationship learning on alliance innovation performance. Future research can also use secondary data to measure alliance innovation performance. Future researchers can examine how guanxi as a relational mechanism governance affects relationship learning.

Practical implications
Managers should conduct relationship learning in the process of alliance innovation and realize that reducing opportunism does not mean improving innovation performance. Moreover, managers should know that guanxi could contribute to alliance innovation performance with the help of formal contracts.

Originality/value
Prior studies have mainly focused on the fundamental requirement of governing knowledge exchange in alliances. Little is known about the mediating effect of relationship learning on the relationship between formal contracts and outcomes of innovation alliances. This study contributes to the literature by filling the gap.
Diversity, equity, inclusion, and brand outcomes: a case of higher education
Authors: Nguyen Thuy D. , Yaghi Majed , Ganesh Gopala , Blankson Charles , Paswan Audhesh K. , Pavur Robert 
Published: November 2024

Purpose
Diversity, equity and inclusion ideology is the latest appeal of individual compassion, institutional legitimacy and enlightened society. Specific to higher education, diversity, equity and inclusion is an honorable ideology, value and mission. This paper aims to (1) empirically recognize the differences in the level of importance between the university’s and faculty’s diversity, equity and inclusion initiatives, (2) identify the diversity, equity and inclusion outcomes, such as university brand image and student intention to engage postgraduation, (3) uncover the moderating role of university brand preference attainment and (4) validate the mediating role of student identification in diversity, equity and inclusion literature.

Design/methodology/approach
A survey of 1,027 usable responses was employed to perform two moderations, four mediations and two confidence interval analyses.

Findings
The university’s diversity, equity and inclusion initiatives are significantly more rewarding than the faculty’s diversity, equity and inclusion initiatives for the university brand image and students’ intention to engage postgraduation. Findings uncover the mediating role of student identification and the moderating role of brand preference attainment.

Practical implications
Focusing on diversity, equity and inclusion at the institutional level is more impactful than at the faculty level. In industries where frontline employees have significant autonomy, such as higher education, the positive brand performance outcomes are related to the faculty’s diversity, equity and inclusion awareness, not the faculty’s diversity, equity and inclusion advocacy. Diversity, equity and inclusion initiatives should align with the student’s shared values.

Originality/value
The study relies on institutional theory to underscore the asymmetric importance of the university’s and faculty’s diversity, equity and inclusion initiatives in achieving perceived brand image and engagement.
Can 21st century women have the best of both worlds? Reality or dream?
Authors: Loh Jennifer , Johns Raechel , English Rebecca 
Published: November 2024

PurposeThis study explored whether women could “have it all,” both at home and in the workplace. Using neoliberal feminism, mental load theory and intergenerational perspective as theoretical frameworks, this study explored how neoliberal ideologies which emphasized individual agency, economic empowerment and self-responsibility interact with persistent gendered expectations/norms to influence women’s experiences in navigating familial commitments and career aspirations.Design/methodology/approachAround 140 (N = 140) women living in Australia were recruited to participate in a qualitative, open-ended questionnaire that aimed to explore their: (1) perceptions and (2) expectations about (a) how gender roles evolved for them from youth to adulthood in various contexts, (b) how their family structures and dynamics, such as attitudes toward marriage, caregiving and/or household responsibilities, have changed and (c) what has/have influenced their career aspirations and family choices.FindingsResults revealed a trend of women who worked hard at home and professionally. Unlike women who in the past lived more traditional lives, women in our cohort focused on their career as an important part of their identity and self-fulfillment. However, many women did report heightened mental load, stress and a lack of physical exercise in their daily lives.Originality/valueThis study revealed complex interplay between societal norms, intergenerational influences and the cognitive burdens associated with managing multiple roles. By examining these dynamics and using an integrated theoretical framework, the article aimed to holistically explain the challenges women in Australia encounter as they try to balance familial obligations with career ambitions within changing socioeconomic contexts.
A backstage look at a near-fiasco of ethnographic access to musical theatre organisations
Authors: Duarte Márcia , Alcadipani Rafael 
Published: November 2024

PurposeThis study explores the trajectory and challenges faced by a doctoral researcher in her successive attempts to gain access for conducting an ethnography within the production or organisation of a musical theatre performance. Contemplating the four unsuccessful access attempts and the final, triumphant one, we ponder the reasons and impediments for conducting research within this particular context. We operate under the premise that research access possesses a relational characteristic, contingent upon the relationships established between the researcher, the researched, potential informants and the dynamics of the field as a whole.Design/methodology/approachThis is an exploratory and qualitative study, and the empirical research is based on an ethnographic-inspired case study of the organisation/production of a musical theatre play in São Paulo, SP, Brazil, which we have given the pseudonym MusiCom.FindingsThe study contributes by allowing us to affirm that access is intertwined with at least two aspects: the peculiarities of the organisation itself and the characteristics or context in which it exists or is constructed, and the identity of the researcher, developed during the formal access negotiations through the relationships formed between her and the subjects during the dynamics of the field.Originality/valueOur contribution reinforces the numerous challenges posed to researchers when conducting ethnographies and illustrates how access relies not solely on the skills, aptitudes and learning of the researchers.
Clinicopathological features and outcomes of rare lung adenocarcinoma metastasis to the thyroid gland: A single‐center, 11‐year experience
Authors: Gao Xuehan , Cao Zhen , Diao Xiayao , Zhang Jiaqi , Zhao Ke , Yang Libing , Qian Zhihong , Zhou Xiaoyun , Guo Chao , Chen Yeye , Liu Ziwen , Li Shanqing 
Published: November 2024

AbstractBackgroundMetastasis to the thyroid gland from lung adenocarcinoma is rare and challenging to diagnose due to similar histopathological features. This study aimed to analyze the clinicopathological characteristics of and treatment strategies for lung adenocarcinoma metastasis to the thyroid based on 11 years of institutional experience.MethodsA retrospective study included patients with lung adenocarcinoma metastasis to the thyroid at our center from 2010 to 2023. Clinicopathological features and clinical outcomes were analyzed.ResultsAmong 9714 lung adenocarcinoma patients, nine patients (five females, 55.6%) were diagnosed with thyroid metastasis, presenting primarily with cough symptoms. Most patients (88.9%) had synchronous tumors, whereas a minority (11.1%) had metachronous tumors. The median time from primary tumor diagnosis to metastasis was 4.8 months. Most patients developed bilateral thyroid metastases (88.9%). Diagnosis of thyroid metastasis was primarily through fine‐needle aspiration (FNA), with one case misdiagnosed as papillary thyroid carcinoma. Immunohistochemical staining revealed thyroid transcription factor‐1 (TTF‐1) and novel aspartic proteinase of pepsin family A (Napsin‐A) positivity and paired box 8 (PAX8) negativity. Genetic testing found epidermal growth factor receptor mutations in 71.4% of patients. The individualized comprehensive therapy included surgery, chemotherapy, immunotherapy, and targeted and supportive therapy. The median overall survival was 56.0 months, with a progression‐free survival of 12.7 months. Kaplan–Meier (K–M) analysis suggested improved survival with no advanced symptoms (p = 0.03) and targeted therapies (p = 0.05).ConclusionsLung adenocarcinoma metastasis to the thyroid is a rare disease, with an incidence of 0.1% among lung adenocarcinoma patients. Early treatment after symptom onset and personalized targeted therapies may improve prognosis. Despite rapid disease progression, favorable outcomes can be achieved with comprehensive treatment.
Auriculotherapy nursing intervention: Development and content validation by specialists
Authors: Argenta Carla , Abido Suzanne Cristina , Adamy Edlamar Kátia , Bavaresco Taline , Dalchiavon Camilla , de Fátima Lucena Amália , Zanatta Elisangela Argenta 
Published: November 2024

AbstractPurposeTo develop and validate the content of the components of the auriculotherapy nursing intervention.MethodsThis descriptive and methodological study was carried out in three steps: an integrative literature review, with a diagnosis of the state of the art and a basis for the study; development of the nursing intervention based on the Nursing Interventions Classification (NIC) and validation by the Kappa Index (k = ≥0.61) and the content validity index (CVI ≥ 0.80). The experts were recruited using the snowball method, who met the inclusion criteria: being a nurse, having completed an auriculotherapy course, having clinical experience with auriculotherapy, and having used the NICs in clinical practice for at least 1 year. The instrument for validation was sent via Google Forms in April 2022.ResultsThe title, definition, and 11 activities of the new nursing intervention with Kappa and CVI indexes accepted for content validity were validated.ConclusionsThe content validation of the nursing intervention was fundamental for the suitability of its components, allowing it to be refined.Implications for nursing practiceThe contribution of the study consists of the possible inclusion of this intervention in the NIC, favoring the use of standardized language in the clinical practice of auriculotherapy.
Breastfeeding supports growth in small for gestational age infants: A systematic review and meta‐analysis
Authors: Resvick Heather , Foster Amber , Hartman Brenda , DaSilva Orlando , Coughlin Kevin , Madill Janet 
Published: November 2024

AbstractAimSmall for gestational age is defined as birthweight <10th percentile on standardised age and sex‐specific growth charts. Rapid catch‐up growth seen post‐natal is associated with adiposity and cardiometabolic syndromes later in life. Breastfeeding has positive effects on growth in premature and low‐birthweight infants. Therefore, examining the impact of exclusive breastfeeding on growth parameters in small for gestational age infants is important.MethodsThe Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement and checklist guided review and meta‐analysis. Four databases were searched.ResultsFive articles (4702 infants) met inclusion criteria. The effect of 4–6 months of breastfeeding on growth was measured using weight, length, head circumference, z‐scores and change between timepoints. Study quality was considered very low using Grading of Recommendations, Assessment, Development and Evaluation tool. Random effects models assessed the effect of breastfeeding on weight and length catch‐up growth. Differences in weight and length were seen (−8.36, 95%CI: −11.26 to −5.46 and −7.50, 95%CI: −1.92 to −4.18, p < 0.001), with substantial heterogeneity (I2 > 90%).ConclusionsBreastmilk supports growth in small for gestational age infants, though limited evidence exists for catch‐up growth in the first 6 months. The magnitude and direction of the effect could not be determined.
Modeling impact of improved forage cultivation on milk productivity and feed sufficiency in semiarid tropics of central India: A doubly robust analysis
Authors: Choudhary Bishwa Bhaskar , Sharma Purushottam , Singh Priyanka , Upadhyay Deepak , Kumar Sunil , Gupta Gaurendra , Kantwa Sita Ram , Wasnik Vinod Kumar , Prasad Mahendra 
Published: November 2024

AbstractThe study using cross‐sectional data collected from 300 dairy farmers has analyzed the factors affecting adoption of improved forage technologies and its impact on milk yield and feed sufficiency in central region. We used inverse‐propensity‐weighting regression adjustment (IPWRA) method as main technique for impact evaluation and checked the robustness of the results using matching methods. Our findings suggest that education status, adult cattle unit, animal breed type, off‐farm income activities, farm size, and access to training and market significantly influence adoption of improved forage technologies and practices. Further, the adoption led to a significant increase in daily milk yield (1.07 to 1.34 L), total dry matter availability by over 27%, and green fodder availability by around 80%. Ration balancing has been identified as a significant concern in the study region. Consequently, the study suggests that adopting a comprehensive approach is necessary to address the issue of proper ration balancing and fully harness the production potential of dairy animals.