bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidisciplinary Approach to Treating Severe Acute Pancreatitis in a Low‐Volume Hospital
Authors: Robin‐Lersundi Alvaro , Abella Alvarez Ana , San Miguel Mendez Carlos , Moreno Elalo‐Olaso Almudena , Cruz Cidoncha Arturo , Aguilera Velardo Asunción , Gordo Vidal Federico , García‐Ureña Miguel‐Angel 
Published: August 2019

AbstractBackgroundUp to 25% of patients with acute pancreatitis develop severe complications and are classified as severe pancreatitis with a high death rate. To improve outcomes, patients may require interventional measures including surgical procedures. Multidisciplinary approach and best practice guidelines are important to decrease mortality.MethodsWe have conducted a retrospective analysis from a prospectively maintained database in a low‐volume hospital. A total of 1075 patients were attended for acute pancreatitis over a ten‐year period. We have analysed 44 patients meeting the criteria for severe acute pancreatitis and for intensive care unit (ICU) admittance. Demographics and clinical data were analysed. Patients were treated according to international guidelines and a multidisciplinary flowchart for acute pancreatitis and a step‐up approach for pancreatic necrosis.ResultsForty‐four patients were admitted to the ICU due to severe acute pancreatitis. Twenty‐five patients needed percutaneous drainage of peri‐pancreatic or abdominal fluid collections or cholecystitis. Eight patients underwent endoscopic retrograde cholangiopancreatography for choledocholithiasis and biliary sepsis or pancreatic leakage, and one patient received endoscopic trans‐gastric endoscopic prosthesis for pancreatic necrosis. Sixteen patients underwent surgery: six patients for septic abdomen, four patients for pancreatic necrosis and two patients due to abdominal compartment syndrome. Four patients had a combination of surgical procedures for pancreatic necrosis and for abdominal compartment syndrome. Overall mortality was 9.1%.ConclusionSevere acute pancreatitis represents a complex pathology that requires a multidisciplinary approach. Establishing best practice treatments and evidence‐based guidelines for severe acute pancreatitis may improve outcomes in low‐volume hospitals.
Laparoscopic Versus Open Complete Mesocolon Excision in Right Colon Cancer: A Systematic Review and Meta‐Analysis
Authors: Chaouch Mohamed Ali , Dougaz Mohamed Wejih , Bouasker Ibtissem , Jerraya Hichem , Ghariani Wafa , Khalfallah Mehdi , Nouira Ramzi , Dziri Chadli 
Published: August 2019

AbstractBackgroundLaparoscopic complete mesocolon excision (LCME) for right colonic cancer improves oncological outcomes. This systematic review and meta‐analysis aimed to compare intraoperative, postoperative, and oncological outcomes after LCME and open total mesocolon excision (OCME) for right‐sided colonic cancers.MethodsLiterature searches of electronic databases and manual searches up to January 31, 2019, were performed. Random‐effects meta‐analysis model was used. Review Manager Version 5.3 was used for pooled estimates.ResultsAfter screening 1334 articles, 10 articles with a total of 2778 patients were eligible for inclusion. Compared to OCME, LCME improves results in terms of overall morbidity (OR = 1.48, 95% CI 1.21 to 1.80, p = 0.0001), blood loss (MD = 56.56, 95% CI 19.05 to 94.06, p = 0.003), hospital stay (MD = 2.18 day, 95% CI 0.54 to 3.83, p = 0.009), and local (OR = 2.12, 95% CI 1.09 to 4.12, p = 0.03) and distant recurrence (OR = 1.63, 95% CI 1.23–2.16, p = 0.0008). There was no significant difference regarding mortality, anastomosis leakage, number of harvested lymph nodes, and 3‐year disease‐free survival. Open approach was significantly better than laparoscopy in terms of operative time (MD = − 34.76 min, 95% CI − 46.01 to − 23.50, p < 0.00001) and chyle leakage (OR = 0.41, 95% CI 0.18 to 0.96, p = 0.04).ConclusionsThis meta‐analysis suggests that LCME in right colon cancer surgery is superior to OCME in terms of overall morbidity, blood loss, hospital stay, and local and distant recurrence with a moderate grade of recommendation due to the retrospective nature of the included studies.
Quality Assessment and Risk of Bias of Systematic Reviews of Prophylactic Mesh for Parastomal Hernia Prevention Using AMSTAR and ROBIS Tools
Authors: García‐Alamino Josep M. , López‐Cano Manuel , Kroese Leonard , Helgstrand Frederik , Muysoms Filip 
Published: August 2019

AbstractBackgroundSystematic reviews play a crucial role in clinical decision making and resource allocation and are expected to be unbiased and consistent. The aim of this study is a review of systematic reviews on the use of prophylactic mesh to prevent parastomal hernia (PH) formation using ROBIS and AMSTAR tools to assess the risk of bias and methodological quality.MethodsWe included systematic reviews with or without meta‐analysis of which the objective was to assess the use of a prophylactic mesh to prevent PH. A systematic search of the literature in five databases from inception until December 2017 was conducted. For each systematic review, methodologic quality and risk of bias were assessed using the AMSTAR and ROBIS tools, respectively. We estimated the inter‐rater reliability for individual domains and for the overall methodological quality and risk of bias using Fleiss’ k.ResultsWe identified 14 systematic reviews that met the inclusion criteria. Using the AMSTAR scale with a cutoff value, six reviews showed high methodologic quality and eight were of low quality. Using the ROBIS tool, the overall risk of bias was low in 50% of the reviews analyzed. In the remaining studies, the risk of bias was unclear.ConclusionsThe global evidence in favor of the use of a prophylactic mesh for preventing PH is not uniform regarding quality and risk of bias. Surgeons cannot be equally confident in the results of all systematic reviews published on this topic.
Towards clinical grating-interferometry mammography
Authors: Arboleda Carolina , Wang Zhentian , Jefimovs Konstantins , Koehler Thomas , Van Stevendaal Udo , Kuhn Norbert , David Bernd , Prevrhal Sven , Lång Kristina , Forte Serafino , Kubik-Huch Rahel Antonia , Leo Cornelia , Singer Gad , Marcon Magda , Boss Andreas , Roessl Ewald , Stampanoni Marco 
Published: August 2019

Abstract

Objectives
Grating-interferometry-based mammography (GIM) might facilitate breast cancer detection, as several research works have demonstrated in a pre-clinical setting, since it is able to provide attenuation, differential phase contrast, and scattering images simultaneously. In order to translate this technique to the clinics, it has to be adapted to cover a large field-of-view within a clinically acceptable exposure time and radiation dose.

Methods
We set up a grating interferometer that fits into a standard mammography system and fulfilled the aforementioned conditions. Here, we present the first mastectomy images acquired with this experimental device.

Results and conclusion
Our system performs at a mean glandular dose of 1.6 mGy for a 5-cm-thick, 18%-dense breast, and a field-of-view of 26 × 21 cm2. It seems to be well-suited as basis for a clinical-environment device. Further, dark-field signals seem to support an improved lesion visualization. Evidently, the effective impact of such indications must be evaluated and quantified within the context of a proper reader study.

Key Points

• Grating-interferometry-based mammography (GIM) might facilitate breast cancer detection, since it is sensitive to refraction and scattering and thus provides additional tissue information.

• The most straightforward way to do grating-interferometry in the clinics is to modify a standard mammography device.

• In a first approximation, the doses given with this technique seem to be similar to those of conventional mammography.
Disc inflammation and Modic changes show an interaction effect on recovery after surgery for lumbar disc herniation
Authors: Djuric Niek , Yang Xiaoyu , Ostelo Raymond W. J. G. , van Duinen Sjoerd G. , Lycklama à Nijeholt Geert J. , van der Kallen Bas F. W. , Peul Wilco C. , Vleggeert-Lankamp Carmen L. A. 
Published: August 2019

Abstract

Purpose
To study the interaction between Modic changes (MC) and inflammation by macrophages in the disc, in relation to clinical symptoms before and after discectomy for lumbar disc herniation.

Methods
Disc tissue was embedded in paraffin and stained with haematoxylin and CD68. Subsequently, tissue samples were categorized for degree of inflammation. Type of MC was scored on MRI at baseline. Roland Disability Questionnaire (RDQ) score and visual analogue scale for back pain and leg pain separately were considered at baseline and 1-year follow-up post-surgery. Main and interaction effects of MC and inflammation were tested against clinical outcome questionnaires. In addition, this analysis was repeated in bulging and extruded discs separately.

Results
Disc material and MRI’s of 119 patients were retrieved and analysed. Forty-eight patients demonstrated mild inflammation, 45 showed moderate inflammation, and 26 showed considerable inflammation. In total, 49 out of 119 patients demonstrated MC. Grade of disc inflammation did not associate with the presence of MC. At baseline, no main or interaction effects of MC and inflammation were found on the clinical scores. However, during follow-up after discectomy, significant interaction effects were found for RDQ score: Only in patients with MC at baseline, patients remained significantly more disabled (3.2 points p = 0.006) if they showed considerable disc inflammation compared to patients with mild inflammation. The additional analysis showed similar results in extruded discs, but no significant effects in bulging discs.

Conclusions
An interaction effect of MC and disc inflammation by macrophages is present. Only in patients with MC, those with considerable inflammation recover less satisfactory during follow-up after surgery.

Graphic abstract
These slides can be retrieved under Electronic Supplementary Material.
Measuring dynamic capabilities in new ventures: exploring strategic change in US green goods manufacturing using website data
Authors: Arora Sanjay K. , Li Yin , Youtie Jan , Shapira Philip 
Published: August 2019

Abstract
Entrepreneurial scholarship suggests that a small firm’s ability to grow is a function of its capacity to sense and respond to changes in the market as well as the broader environment for the firm’s goods and services. Developing detailed measures of internal capabilities at a large scale, however, is often hampered by limitations in the availability of data from conventional sources, low survey response rates and panel attrition. The emergence of new information sources, including big data sets derived from the online activities of firms, coupled with advanced computational approaches, raises fresh analytical possibilities. In this exploratory study, we turn to freely accessible website data to gauge internal capabilities, specifically for market sensing and responding. To operationalize the construct of seizing, the paper uses an application of topic modeling, a text mining approach commonly used in computer science, on archived website data from the Wayback Machine for two time periods, 2008–2009 and 2010–2011, to explain sales growth for green goods enterprises in two later time periods, from 2010 to 2012. We find an endogenous inverse U-shaped relationship exists between market seizing and sales growth. Increasing levels of focus on a firm’s local geographic area also predict sales growth. We consider these findings in light of the practitioner literature on firm agility and pivoting and discuss opportunities for future work using website data to study entrepreneurship and the strategic management of innovation.
Experimental research on novel oil displacement and profile control system for heterogeneous reservoir
Authors: Lv Peng , Liu Yigang , Zhang Yunbao , Li Yanyue , Xia Huan 
Published: August 2019

AbstractPolymer flooding and surfactant/polymer flooding (SP flooding) were mainly focused on the improvement in oil–water flow ratio and the reduction in oil–water interfacial tension. Preformed particle gel (PPG) flooding was mainly focused on the reservoir heterogeneity improvement. Each of these technologies has its own limitations. Heterogeneous system flooding (HS–PP flooding) was proposed as a novel flooding method aimed to improve oil–water flow ratio and reservoir heterogeneity at the same time. The HS–PP flooding system was composed of PPG and polymer solution. HS–PP flooding, polymer flooding and SP flooding as different chemical EOR methods were studied in laboratory in physical simulation heterogeneous model. Property of cubic expansion of PPG was researched by laser particle analyzer. The result shows that cubic expansion of PPG in simulation water is obvious and can be controlled. The effect of PPG on the diversion rate modification in double parallel sandstone model was obvious. The oil displacement experiments of the three different flooding systems with the same viscosity in physical simulation heterogeneous model were studied. The results show that the HS–PP flooding improves the oil recovery by 20.04%, comparing the result of 12.67% for polymer flooding and 16.66% for SP flooding, respectively. HS–PP flooding as a novel flooding method shows an excellent ability for stabilizing oil production and controlling water cut. The mechanism of the HS–PP flooding was discussed briefly. In addition to the viscoelastic displacement of polymers, the special circulation ability of “accumulating–deforming (collapsing)–accumulating again” of PPG is the main reason why the HS–PP flooding shows an excellent property for stabilizing oil production and controlling water cut.
Influence of Genotype and Hyperandrogenism on Sexual Function in Women With Congenital Adrenal Hyperplasia
Authors: Schernthaner-Reiter Marie Helene , Baumgartner-Parzer Sabina , Egarter Hans Christian , Krebs Michael , Kautzky-Willer Alexandra , Kirchheiner Kathrin , Luger Anton , Bayerle-Eder Michaela 
Published: August 2019

Abstract

Background
Depending on CYP21A2 genotype, congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency leads to biochemical alterations (including hyperandrogenism, hypocortisolism, and hypoaldosteronism) and a wide spectrum of phenotypic disease manifestation. The latter include life-threatening salt-wasting crises, prenatal virilization of genitalia in women (classic CAH [C-CAH]) as well as milder forms of the disease exclusively presenting with hirsutism, acne or reduced fertility (nonclassic CAH [NC-CAH]), and could influence sexual function and identity.

Aim
The present study evaluated sexual function, gender identification, and partner preference in women with C-CAH and NC-CAH.

Methods
In a cross-sectional cohort analysis, 35 female patients with CAH were divided into 2 groups: C-CAH (salt-wasting/simple virilizing; n = 17) and NC-CAH (n = 18) according to genotype and phenotype. Sexual function and sexual distress were assessed using established questionnaires, including the Female Sexual Function Index. Phenotype (defined by signs of hyperandrogenism) was assessed clinically (Ferriman-Gallwey score) and with the ovulatory function index. CYP21A2 genotype was determined by Sanger sequencing and multiplex ligation-dependent probe amplification. Sexual function was also separately analyzed in the context of clinical signs of androgenization in women with (n = 13) and without acne (n = 22).

Outcomes
The study outcomes were sexual function and sexual distress in relation to genotype, clinical signs of androgenization, and biochemical parameters.

Results
Women with NC-CAH had significantly lower orgasm scores, a trend toward lower sexual function with higher sexual distress, as well as biochemical evidence of hyperandrogenism (higher dehydroepiandrosterone sulfate and lower SHBG) and a trend toward more clinical signs of hyperandrogenism (hirsutism). Indicators of in utero and childhood androgen excess as well as the presence of acne in all patients were related to lower sexual function and higher sexual distress. Clinical signs of hyperandrogenism correlated well with cardiovascular and metabolic risk factors.

Clinical Translation
Women with NC-CAH and women with clinical signs of hyperandrogenism demonstrated higher distress compared to women with C-CAH and women without clinical signs of hyperandrogenism, respectively, regarding different aspects of sexual function.

Conclusions
These data underline the importance of early diagnosis and therapy initiation, especially in patients with NC-CAH.
Current Legal Situation for Patients with Paraphilic disorders and Implications of the ICD-11 for Paraphilic Disorders for Germany
Authors: Briken Peer , Boetticher Axel , Krueger Richard B. , Kismödi Eszter , Reed Geoffrey M. 
Published: August 2019

Abstract

Introduction
Recently the guidelines for the diagnosis of paraphilic disorders in the International Classification of Diseases and Related Health Problems, Eleventh Revision (ICD-11), have been published.

Aim
This article analyzes legal, regulatory, and policy issues relevant to the potential effects of the changes for the classification of paraphilic disorders in the ICD-11 in Germany.

Methods
A forensic and a legal expert in Germany worked with other international experts to conduct this evaluation using an assessment guide provided by the World Health Organization.

Main Outcome Measures
Possible effects of the changes for the classification of paraphilic disorders in the ICD-11 on forensic practice, health systems, adjudication of individuals who have committed a sexual offense, and the provision of treatment in Germany.

Results
Results highlight the special situation of medical confidentiality in the German health system that facilitates the establishment of preventive networks for the treatment of pedophilic patients. The ICD-11 guidelines will help to clarify the boundary between pedophilic disorder and crimes of child sexual abuse. These will also establish a boundary with other paraphilic diagnostic concepts. We describe the central construct of criminal responsibility in the German legal system in relation to paraphilic disorders, the prominent role of expert witnesses, and the differences in the conceptualization of medical confidentiality within the health care system and within the legal system.

Clinical Implications
The ICD-11 proposals for paraphilic disorders provide a clearer differentiation, as compared with ICD-10, between variants of normal sexual behavior and sexual behavior that involves a non-consenting person or entity. Particular patterns of sexual preference that are not of relevance to public health, the health care system, or the legal system, such as masochism and fetishism, will no longer be named psychiatric entities and will, therefore, be regarded as private behaviors and destigmatized.

Strengths & Limitations
The assessment shows the specific legal situation in Germany for the treatment of paraphilic patients in a sexual medicine, psychiatric, and legal discourse. However, it was done only by a small number of experts.

Conclusion
A conclusion of the analysis was that the more specific and narrower definitions in the ICD-11 diagnostic guidelines, compared with those in ICD-10, particularly for pedophilic disorder and coercive sexual sadism disorder, will result in a reduction in false-positive diagnoses. It is unlikely that significant unintended and negative consequences will occur as a result of implementing the ICD-11 guidelines for paraphilic disorders.
When “Green” Equals Thorny and Mean: The Politics and Costs of an Environmental Experiment in East Africa
Authors: Little Peter D. 
Published: August 2019

Abstract:This article examines an environmental experiment in northern Kenya that went badly amiss. Focusing on the introduction of an invasive plant, prosopis juliflora, it explores wider issues of scientific hegemony, political identity, and land conflicts. Two legal cases pitting a small pastoralist community against the Kenyan state are discussed, which reveal a new but generally unsuccessful strategy by indigenous groups of utilizing courts to address injustices. The research draws on ethnographic, archival, and visual materials collected over a thirty-five-year period to demonstrate the violence and impoverishment that can be associated with technical interventions aimed at “greening” the environment.
Banks, power, and political institutions: the divergent priorities of European states towards “too-big-to-fail” banks: The cases of competition in retail banking and the banking structural reform
Authors: Massoc Elsa 
Published: August 2019

AbstractThis article examines how two dynamics, one global and one domestic, have interacted to shape the politics of banking in Europe. In the aftermath of the 2008 crisis, European governments were subject to renewed structural incentive to promote TBTF banks: in financialized economies, the growth of these banks is perceived as an essential element of a national economy's global competitiveness. Yet, this incentive was subject to enhanced political contention at home. Factions—often led by actors from within the state itself—have opposed governments’ impetus to promote TBTF banks. The specific identity, preferences and resources of these factions are determined by distinctive political institutions and vary across countries. Through the comparative analysis of banking structural reform and banking competition policies in the UK, France and Germany, I argue that varieties of regulatory outcomes are explained by the differentiated institutional capacity of “anti-TBTF” factions to carry weight in policymaking processes across jurisdictions.
Forecasting human capital of EU member countries accounting for sociocultural determinants
Authors: Marois Guillaume , Sabourin Patrick , Bélanger Alain 
Published: August 2019

AbstractInclusion of additional dimensions to population projections can lead to an improvement in the overall quality of the projections and to an enhanced analytical potential of derived projections such as literacy skills and labor force participation. This paper describes the modeling of educational attainment of a microsimulation projection model of the European Union countries. Using ordered logistic regressions on five waves of the European Social Survey, we estimate the impact of mother's education and other sociocultural characteristics on educational attainment and implement them into the microsimulation model. Results of the different projection scenarios are contrasted to understand how the education of the mother and sociocultural variables may affect projection outcomes. We show that a change in the impact of mother's education on children's educational attainment may have a big effect on future trends. Moreover, the proposed approach yields more consistent population projection outputs for specific subpopulations.