bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep SOLO: A Full-Depth Profiling Float for the Argo Program
Authors: Roemmich Dean , Sherman Jeffrey T. , Davis Russ E. , Grindley Kyle , McClune Michael , Parker Charles J. , Black David N. , Zilberman Nathalie , Purkey Sarah G. , Sutton Philip J. H. , Gilson John 
Published: August 2019

AbstractDeployment of Deep Argo regional pilot arrays is underway as a step toward a global array of 1250 surface-to-bottom profiling floats embedded in the upper-ocean (2000 m) Argo Program. Of the 80 active Deep Argo floats as of July 2019, 55 are Deep Sounding Oceanographic Lagrangian Observer (SOLO) 6000-m instruments, and the rest are composed of three additional models profiling to either 4000 or 6000 m. Early success of the Deep SOLO is owed partly to its evolution from the Core Argo SOLO-II. Here, Deep SOLO design choices are described, including the spherical glass pressure housing, the hydraulics system, and the passive bottom detection system. Operation of Deep SOLO is flexible, with the mission parameters being adjustable from shore via Iridium communications. Long lifetime is a key element in sustaining a global array, and Deep SOLO combines a long battery life of over 200 cycles to 6000 m with robust operation and a low failure rate. The scientific value of Deep SOLO is illustrated, including examples of its ability (i) to observe large-scale spatial and temporal variability in deep ocean temperature and salinity, (ii) to sample newly formed water masses year-round and within a few meters of the sea floor, and (iii) to explore the poorly known abyssal velocity field and deep circulation of the World Ocean. Deep SOLO’s full-depth range and its potential for global coverage are critical attributes for complementing the Core Argo Program and achieving these objectives.
A Method to Control the Environmental Wind Profile in Idealized Simulations of Deep Convection with Surface Friction
Authors: Dawson II Daniel T. , Roberts Brett , Xue Ming 
Published: August 2019

Abstract
In idealized, horizontally homogeneous, cloud model simulations of convective storms, the action of surface friction can substantially modify the near-ground environmental wind profile over time owing to the lack of a large-scale pressure gradient force to balance the frictional force together with the Coriolis force. This situation is undesirable for many applications where the impact of an unchanging environmental low-level wind shear on the simulated storm behavior is the focus of investigation, as it introduces additional variability in the experiment and accordingly complicates interpretation of the results. Partly for this reason, many researchers have opted to perform simulations with free-slip lower boundary conditions, which with appropriate boundary conditions allows for more precise control of the large-scale environmental wind profile. Yet, some recent studies have advocated important roles of surface friction in storm dynamics. Here, a simple method is introduced to effectively maintain any chosen environmental wind profile in idealized storm simulations in the presence of surface friction and both resolved and subgrid-scale turbulent mixing. The method is demonstrated through comparisons of simulations of a tornadic supercell with and without surface friction and with or without invoking the new method. The method is compared with similar techniques in the literature and potential extensions and other applications are discussed.
Introducing Lightning Threat Messaging Using the GOES-16 Day Cloud Phase Distinction RGB Composite
Authors: Elsenheimer Cynthia B. , Gravelle Chad M. 
Published: August 2019

Abstract
In 2001, the National Weather Service (NWS) began a Lightning Safety Awareness Campaign to reduce lightning-related fatalities in the United States. Although fatalities have decreased 41% since the campaign began, lightning still poses a significant threat to public safety as the majority of victims have little or no warning of cloud-to-ground lightning. This suggests it would be valuable to message the threat of lightning before it occurs, especially to NWS core partners that have the responsibility to protect large numbers of people. During the summer of 2018, a subset of forecasters from the Jacksonville, Florida, NWS Weather Forecast Office investigated if messaging the threat of cloud-to-ground (CG) lightning in developing convection was possible. Based on previous CG lightning forecasting research, forecasters incorporated new high-resolution Geostationary Operational Environmental Satellite (GOES)-16 Day Cloud Phase Distinction red–green–blue (RGB) composite imagery with Multi-Radar Multi-Sensor isothermal reflectivity and total lightning data to determine if there was enough confidence to message the threat of CG lightning before it occurred. This paper will introduce the Day Cloud Phase Distinction RGB composite, show how it can add value for short-term lightning forecasting, and provide an operational example illustrating how fusing these datasets together may be able to provide confidence and extend the lead time when messaging the threat of cloud-to-ground lightning before it occurs.
The Impact of Hours of Advance Notice on Protective Action in Response to Tornadoes
Authors: Krocak Makenzie J. , Ripberger Joseph T. , Jenkins-Smith Hank , Silva Carol 
Published: August 2019

Abstract
As numerical modeling methods and forecasting technologies continue to improve, people may start to see more specific severe weather timing and location information hours before the event occurs. While studies have investigated response actions on the warning time scales, little work has been done to understand what types of actions residents will take given 4–8 h of advance notice for a possible tornado. This study uses data from the 2018 Severe Weather and Society Survey, an annual survey of U.S. adults, to begin analyzing response actions and how those responses differ with either 4 or 8 h of advance notice. Results show that response actions are largely the same between the two time periods. The small differences that do exist show that sheltering behaviors are more common with 4 h of advance notice whereas monitoring behaviors are more common with 8 h of notice. In addition, respondents claimed they would “wait and see” more often in the 8-h category, indicating they would seek additional information before deciding how to respond. Perhaps more important than the types of actions that respondents identify is the increase in those who are unsure of how to react or would choose to do nothing when given 8 h of notice. Respondents may be anchored to the current system and may not have considered all of the possible actions they can take given more time. Therefore, we emphasize the need for education campaigns as technology, forecasts, and desired responses continue to evolve.
Association Between Self-Reported Hypertension and Antihypertensive Medication Use and Cardiovascular Disease–Related Events and Expenditures Among Patients Diagnosed With Hypertension
Authors: Baker-Goering Madeleine M. , Howard David H. , Will Julie C. , Beeler Asay Garrett R. , Roy Kakoli 
Published: August 2019

Objectives: Research suggests that persons who are aware of the risk factors for cardiovascular disease (CVD) are more likely to engage in healthy behaviors than persons who are not aware of the risk factors. We examined whether patients whose insurance claims included an International Classification of Diseases, Ninth Revision (ICD-9) code associated with hypertension who self-reported high blood pressure were more likely to fill antihypertensive medication prescriptions and less likely to have CVD-related emergency department visits and hospitalizations (hereinafter, CVD-related events) and related medical expenditures than patients with these codes who did not self-report high blood pressure. Methods: We used a large convenience sample from the MarketScan Commercial Database linked with the MarketScan Health Risk Assessment (HRA) Database to identify patients aged 18-64 in the United States whose insurance claims included an ICD-9 code associated with hypertension and who completed an HRA from 2008 through 2012 (n = 111 655). We used multivariate logistic regression analysis to examine the association between self-reported high blood pressure and (1) filling prescriptions for antihypertensive medications and (2) CVD-related events. Because most patients with hypertension will not have a CVD-related event, we used a 2-part model to analyze medical expenditures. The first part estimated the likelihood of a CVD-related event, and the second part estimated expenditures. Results: Patients with an ICD-9 code of hypertension who self-reported high blood pressure had a significantly higher predicted probability of filling antihypertensive medication prescriptions (26.5%; 95% confidence interval, 25.7-27.3; P < .001), had a significantly lower predicted probability of a CVD-related event (0.6%, P < .001), and on average spent significantly less on CVD-related events ($251, P = .01) than patients who did not self-report high blood pressure. Conclusion: This study affirms that self-knowledge of high blood pressure, even among patients who are diagnosed and treated for hypertension, can be improved. Interventions that improve patients’ awareness of their hypertension may improve antihypertensive medication use and reduce adverse CVD-related events.
First-Time Experience in Owning a Dog Guide by Older Adults with Vision Loss
Authors: Li Kitsum , Kou Jeffrey , Lam Yvonne , Lyons Patricia , Nguyen Susan 
Published: August 2019

Introduction: In spite of the vast amount of literature on pet therapy and dog companionship, limited studies exist on older adults with vision loss and the experience of owning a dog guide. The purpose of this study is to explore the facilitators and barriers of first-time ownership and utilization of a dog guide as experienced by older adults with vision loss. Methods: Data were gathered among seven participants using open-ended semistructured telephone interviews. Participants described their experiences related to owning a dog guide. Using phenomenological analysis, themes were extracted from verbatim transcriptions. Results: Through constant comparison methods, five themes emerged: increased responsibilities for new dog guide owners, changes in habits and routines, quick human–dog guide bonding, increase in community integration, and enhancement of autonomy through dog guide ownership. Discussion: The study results suggest that obtaining a dog guide increased the older adults with vision loss everyday engagement in community activities. The increased confidence in independent mobility may have led participants to engage in activities in unfamiliar environments, thus improving their autonomy, self-esteem, and physical abilities. These changes resulted in increased feelings of independence and freedom for the older adults with vision loss. Participants also revealed positive changes in their daily habits. Due to the increased physical ability and motivation needed to complete activities, making adjustments to owning a dog guide became easier. Furthermore, a human–dog guide bond was prevalent among all seven participants. Implications for practitioners: Themes extracted provide health practitioners and dog guide organizations insight into how owning dog guides may empower older adults with vision loss.
Tumor-Treating Fields Induce RAW264.7 Macrophage Activation Via NK-κB/MAPK Signaling Pathways
Authors: Park Jeong-In , Song Kyung-Hee , Jung Seung-Youn , Ahn Jiyeon , Hwang Sang-Gu , Kim Joon , Kim Eun Ho , Song Jie-Young 
Published: August 2019

Objective: Tumor-treating fields are currently used to successfully treat various cancers; however, the specific pathways associated with its efficacy remain unknown in the immune responses. Here, we evaluated tumor-treating fields–mediated initiation of the macrophage-specific immune response. Materials and Methods: We subjected RAW 264.7 mouse macrophages to clinically relevant levels of tumor-treating fields (0.9 V/cm, 150 kHz) and evaluated alterations in cytokine expression and release, as well as cell viability. Additionally, we investigated the status of immunomodulatory pathways to determine their roles in tumor-treating fields–mediated immune activation. Results and Discussion: Our results indicated that tumor-treating fields treatment at 0.9 V/cm decreased cell viability and increased cytokine messenger RNA/protein levels, as well as levels of nitric oxide and reactive oxygen species, relative to controls. The levels of tumor necrosis factor α, interleukin 1β, and interleukin 6 were markedly increased in tumor-treating fields–treated RAW 264.7 cells cocultured with 4T1 murine mammary carcinoma cells compared with those in 4T1 or RAW 264.7 cells with or without tumor-treating fields treatment. Moreover, the viability of 4T1 cells treated with the conditioned medium of tumor-treating fields–stimulated RAW 264.7 cells decreased, indicating that macrophage activation by tumor-treating fields effectively killed the tumor cells. Moreover, tumor-treating fields treatment activated the nuclear factor κB and mitogen-activated protein kinase pathways involved in immunomodulatory signaling. Conclusion: These results provide critical insights into the mechanisms through which tumor-treating fields affect macrophage-specific immune responses and the efficacy of this method for cancer treatment.
Residual platelet reactivity after pre-treatment with ticagrelor prior to primary percutaneous coronary intervention is associated with suboptimal myocardial reperfusion
Authors: Roule Vincent , Heudel Thibaut , Lemaitre Adrien , Bignon Mathieu , Ardouin Pierre , Sabatier Rémi , Blanchart Katrien , Beygui Farzin 
Published: August 2019

Abstract

Background
The evidence of a clinical benefit of P2Y12 inhibitor pre-treatment in primary percutaneous coronary intervention (PCI) and the relation between the level of platelet inhibition and myocardial reperfusion with newer potent P2Y12 inhibitors remain unclear. We aimed to assess the relationship between platelet reactivity at the time of primary PCI after pre-treatment with aspirin and ticagrelor and the post-PCI myocardial blush grade (MBG).

Methods
We prospectively included 61 patients. Platelet reaction units for ticagrelor (PRU) and aspirin reaction units (ARU) were measured using the point-of-care test VerifyNow before PCI. The high on-ticagrelor (PRU &gt;208) and on-aspirin (ARU ⩾ 550) platelet reactivity (HPR and HaPR) were assessed. Patients were divided into two groups according to MBG 3 or &lt;3.

Results
MBG 3 was identified in 28 (46%) patients. Mean PRU was lower in such patients as compared with those with MBG &lt;3 (155.82 ± 90.91 vs. 227.42 ± 65.18; p=0.001) while mean ARU was similar between groups. HPR and HaPR were observed in 30 (49.2%) and 11 patients (18%), respectively. HPR but not HaPR was more frequent in the group with impaired MBG (66.7 vs. 28.6%; p=0.003 and 21.2 vs. 14.3%; p=0.48 respectively).

Conclusion
Our study shows that higher PRU and the subsequent HPR at the time of primary PCI, after pretreatment with ticagrelor, are the only correlates of post PCI MBG. These findings support the earliest possible loading with ticagrelor prior to primary PCI.
Medical Supervision of High School Athletics in Chicago: A Follow-up Study
Authors: Jones Nathaniel S. , Wieschhaus Kyle , Martin Brendan , Tonino Pietro M. 
Published: August 2019

Background: High school sports participation in the United States has increased dramatically over the past 25 years. A corresponding increase in the number of injuries has been noted, particularly in contact sports such as football. This has led medical and sports organizations nationwide to advocate for proper medical supervision of athletes at games and practices. Purpose: To gather information from Chicago public high schools to gauge how medical supervision for high school sports has changed in 2017 compared with 2003. Study Design: Cross-sectional study. Methods: Survey questionnaires were sent to the athletic directors of all 99 Chicago public high schools to complete via email. The questionnaire survey contained the same questions as in a survey conducted in 2003 by Tonino and Bollier, with the addition of 4 novel questions relating to emergency action plans (EAPs), automated external defibrillators, concussion management policy, and tackling progression drills. Results: The response rate was 66.67% (66/99 schools). Of the 66 responding schools, all with football programs, no school had a physician on the sideline at home games (decrease from 10.6% in 2003), 37.9% had an athletic trainer present (increase from 8.5% in 2003), and 63.6% had a paramedic available (decrease from 89.4% in 2003). In 2017, 65.6% of responding schools had a coach certified in cardiopulmonary resuscitation (CPR) available at practice to handle medical problems, compared with 89.4% in 2003 ( P < .001). Regarding the 4 novel questions, 93.9% of the responding schools had proper tackling progression drills in place, followed by 89.1% who had appropriate EAPs and 93.9% with concussion management protocols, including return-to-play and return-to-learn protocols. Conclusion: Although significant improvement was found in athletic trainer coverage, especially at games, physician coverage was lacking and fewer coaches were certified in CPR in 2017 compared with 2003. EAPs and concussion management protocols were present in most Chicago public high schools. Overall, greater medical supervision is needed, which we believe should come in the form of increased athletic training and physician involvement and coverage, given that expert, expedited medical care saves lives.
A pilot study of pembrolizumab in smoldering myeloma: report of the clinical, immune, and genomic analysis
Authors: Manasanch Elisabet E. , Han Guangchun , Mathur Rohit , Qing Yun , Zhang Zheng , Lee Hans , Weber Donna M. , Amini Behrang , Berkova Zuzana , Eterovic Karina , Zhang Shaojun , Zhang Jianhua , Song Xingzhi , Mao Xizeng , Morgan Margaret , Feng Lei , Baladandayuthapani Veera , Futreal Andrew , Wang Linghua , Neelapu Sattva S. , Orlowski Robert Z. 
Published: August 2019

Abstract
Multiple myeloma is, in most patients, an incurable cancer. Its precursors can be identified with routine tests setting the stage for early intervention to prevent active myeloma. We investigated the efficacy and safety of pembrolizumab, an antiprogrammed cell death 1 antibody, in smoldering myeloma patients with intermediate/high risk of progression to symptomatic myeloma. Thirteen patients were treated with a median number of 8 cycles. One patient achieved a stringent complete response with bone marrow next-generation sequencing negativity at 10−4 that is ongoing at 27 months (8%); 11 had stable disease (85%), and 1 progressed (8%). Three patients discontinued therapy due to immune-related adverse events: 2 with transaminitis and 1 due to tubulointerstitial nephritis. Immune profiling of bone marrow samples at baseline showed markers associated with a preexisting immune response in the responder compared with nonresponders and features of increased T-cell exhaustion in nonresponders. Consistent with this, transcriptome sequencing of bone marrow samples at baseline revealed an increased interferon-γ signature in the responder compared with the nonresponders. In summary, our results suggest that smoldering myeloma may be immunogenic in a subset of patients, and therapies that enhance antitumor T-cell responses may be effective in preventing its progression. This trial was registered at www.clinicaltrials.gov as #NCT02603887.
Systematic review and meta-analysis of the efficacy and safety of apixaban compared to rivaroxaban in acute VTE in the real world
Authors: Aryal Madan Raj , Gosain Rohit , Donato Anthony , Yu Han , Katel Anjan , Bhandari Yashoda , Dhital Rashmi , Kouides Peter A. 
Published: August 2019

Abstract
Both apixaban and rivaroxaban have been approved for use in acute venous thromboembolism (VTE). Although indirect comparison through network meta-analyses of randomized trials have been performed to compare the efficacy and safety of these agents, further comparison between these agents was lacking until recently. We sought to systematically review and carry out a meta-analysis of studies to further compare apixaban with rivaroxaban from multiple studies done in the real-world settings. Studies comparing rivaroxaban with apixaban in patients with acute VTE were identified through electronic literature searches of MEDLINE, EMBASE, Scopus, and the Cochrane library up to May 2019. Study-specific risk ratios (RRs) were calculated and combined using a random-effects model meta-analysis. In an analysis involving 24 041 patients, recurrent VTE within 6 months occurred in 56 of 4897 patients (1.14%) in the apixaban group and 258 of 19 144 patients (1.35%) in the rivaroxaban group (RR, 0.89; 95% confidence interval [CI], 0.67-1.19; P = .45). Clinically relevant major bleeding occurred in 85 of 11 559 patients (0.74%) in the apixaban group and 350 of 33 909 patients (1.03%) in the rivaroxaban group (RR, 0.73; 95% CI, 0.58-0.93; P = .01). Clinically relevant nonmajor bleeding occurred in 169 of 3417 patients (4.95%) in the apixaban group and 1094 of 12 475 patients (8.77%) in the rivaroxaban group (RR, 0.59; 95% CI, 0.50-0.70; P &lt; .01). Apixaban shows equivalent efficacy in prevention of recurrent VTE but decreased risk of major and minor bleeding events compared with rivaroxaban.
RNA sequencing of transplant-stage idiopathic pulmonary fibrosis lung reveals unique pathway regulation
Authors: Sivakumar Pitchumani , Thompson John Ryan , Ammar Ron , Porteous Mary , McCoubrey Carly , Cantu Edward , Ravi Kandasamy , Zhang Yan , Luo Yi , Streltsov Denis , Beers Michael F. , Jarai Gabor , Christie Jason D. 
Published: August 2019

Idiopathic pulmonary fibrosis (IPF), the scarring of lung parenchyma resulting in the loss of lung function, remains a fatal disease with a significant unmet medical need. Patients with severe IPF often develop acute exacerbations resulting in the rapid deterioration of lung function, requiring transplantation. Understanding the pathophysiological mechanisms contributing to IPF is key to develop novel therapeutic approaches for end-stage disease.We report here RNA-sequencing analyses of lung tissues from a cohort of patients with transplant-stage IPF (n=36), compared with acute lung injury (ALI) (n=11) and nondisease controls (n=19), that reveal a robust gene expression signature unique to end-stage IPF. In addition to extracellular matrix remodelling pathways, we identified pathways associated with T-cell infiltration/activation, tumour development, and cholesterol homeostasis, as well as novel alternatively spliced transcripts that are differentially regulated in the advanced IPF lungversusALI or nondisease controls. Additionally, we show a subset of genes that are correlated with percent predicted forced vital capacity and could reflect disease severity.Our results establish a robust transcriptomic fingerprint of an advanced IPF lung that is distinct from previously reported microarray signatures of moderate, stable or progressive IPF and identifies hitherto unknown candidate targets and pathways for therapeutic intervention in late-stage IPF as well as biomarkers to characterise disease progression and enable patient stratification.