bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into the physicochemical stability of ammonium glycyrrhizate and curcumin nanocomplexes
Authors: Wang Yonghui , Wu Jingwen , Guo Weiyun , Gao Xueli , Li Guanghui , He Shenghua , Huang Jihong , Du Zirui , Wen Sa 
Published: February 2025

Abstract
In this study, ammonium glycyrrhizate (AG) based curcumin (Cur) nanocomplexes (AG/Cur NCs) were prepared. Water solubility of Cur and the physical stability of AG/Cur NCs under varying conditions were investigated, and the stability and bioaccessibility of Cur during in vitro digestion were also studied. The results showed that Cur solubility and physical stability of the NCs increased significantly (p < 0.05) with the increase of AG concentration. The solubility of encapsulated Cur and the physical stability of AG/Cur NCs were affected by the changes in pH, salt concentration, and temperature, but the NCs showed good stability against various environmental conditions. After in vitro simulated digestion, the stability and bioaccessibility of the embedded Cur in the NCs were 6.54 % and 21.70 % respectively, higher than that of free Cur. The formulation of AG/Cur NCs significantly enhanced the solubility and stability of Cur, indicating substantial promising for Cur-based functional foods.
Understanding public awareness of fall epidemiology in the United States: A national cross-sectional study
Authors: Sheridan Elizabeth , Wiseman Jessica M. , Quatman Carmen E. 
Published: February 2025

Abstract

Background and objectives
Falls are a leading cause of death and disability for adults aged 65 and older, despite the availability of evidence-based interventions to decrease fall risk. We sought to assess public awareness of falls in the United States (US), including when falls are most likely to occur.

Methods
An online survey was distributed to US adults aged 18 or older.

Results
A total of 1,069 individuals agreed to be contacted for the study, and 966 (90.4%) of them participated in the study. The largest proportion of participants believed that falls are most likely to occur at night (41.2%). Most of the participants correctly identified falls as preventable (97.9%) and recognized homes as the primary location (94.8%). Participants understood the increased risk of subsequent falls after a single fall (97.4%) and the low rate of informing doctors after a fall (82.9%). However, many were unaware that falls are not a normal part of aging (58.8%), one in four older adults fall annually (58.0%), most falls do not cause injury (60.8%), or that $50 billion is the annual cost of falls (96.3%).

Conclusions
This study reveals gaps in public awareness of fall epidemiology and severity among older adults. Contrary to common belief, falls occur predominantly during morning and afternoon hours, not in the evening or at night. While most respondents correctly identified falls as preventable, many erroneously considered them an inevitable consequence of aging. Additionally, the actual medical costs of falls far exceed public estimates. These findings underscore the need for targeted public health interventions to address misconceptions and enhance the awareness of fall risks and prevention strategies.
Mehrebenenannotation argumentativer Lerner*innentexte für die automatische Textauswertung
Authors: Kilsbach Sebastian , Rezat Sara , Michel Nadine , Karabey Rabia , Stahl Maja , Wachsmuth Henning 
Published: February 2025

Abstract
This article presents a multi-level annotation approach for argumentative learner texts that was developed as part of an interdisciplinary DFG project. The project aims at the automated generation of individualized, development-promoting and learner-sensitive feedback on argumentative student texts and is situated in the field of AI-supported text production. To generate automated feedback, the first step was to manually annotate an extensive text corpus consisting of 1,320 argumentative texts written by fifth and ninth graders. This then formed the basis for the development of corresponding computational linguistic procedures. The article focuses on the special features as well as the challenges that arose in connection with the annotation of learner texts and the generation of learner-sensitive feedback. The article is structured as follows: First, the relevant computational linguistics and language didactics research findings and digital support systems for argumentative writing are outlined. In the main part, the procedure of multi-level annotation is explained in detail. Due to the methodological approach, above-average inter-annotator agreement was achieved resulting in the multi-level approach implemented being adaptable for further corpus-based studies. Finally, the results are interpreted and discussed.
The Resilience and Vulnerability of Hungarian Eldercare Workers Abroad in the Light of Covid
Authors: Turai Tünde 
Published: February 2025

AbstractResilience, adaptation, survival, endurance, change, transformation, imbalance – these are all responses to crisis situations and social and economic stresses that are increasingly becoming the focus of academic and public interest. The Carpathian Basin is constantly exposed to strong external influences, to which the local communities, households, and individuals must respond in order to regain their balance, or to transition to a new mode of functioning. In the last three to four decades labor migration became one of the most prominent responses to economic and social pressures and a coping strategy. The convertibility of inequalities and resources between different regions is an opportunity for stabilizing the state of insecurity at home. For the last few years, it has been a common preconception in resilience theories that only strong entities are capable of resilience. Recent research shows that resilience and vulnerability are not mutually exclusive; I offer case studies which illustrate this point. I draw on 15 years of fieldwork with Central and Eastern European migrant women working as care workers in Western countries and Israel. These cases show that the experience of vulnerability and the skills and knowledge gained from it contribute to increasing flexibility, adaptability, and learning capacity, and thus practically lay the foundation for resilient behavior. My research also explores the controversial issue in resilience theories of how responsibility is constituted; i.e., whether the idea of resilience is related to the shifting of responsibility from the social classes in power to the vulnerable groups more prone to disequilibrium. In examining foreign women integrated into the low-level segment of the occupational structure, eldercare, I find that if their physical or mental condition deteriorates, and they are on their own, their vulnerability increases, and the disequilibrium resulting from systemic problems can no longer be corrected through individual resourcefulness alone.
Co-fermentation of Cabernet Sauvignon with table Muscat grape varieties: Effect of addition amount and drying treatment on wine quality
Authors: Wang Z.Y. , Lan M.Z. , Zhang W.J. , Luo X.R. , Li Y.Y. , Wang J. 
Published: February 2025

AbstractTwo Muscat grapes, Zaoheibao and Xiahei, with strong aroma were selected, co-fermented with Cabernet Sauvignon grapes (CFZ and CFX) in different proportions, and dried (CZD and and CXD). The physicochemical characteristics, colour, and volatile compounds in wine samples were measured. Compared with Cabernet Sauvignon wine, drying reduced the aroma compounds and colour but increased phenols content, improving overall quality based on sensory evaluation, especially for Zaoheibao (CZD, 3:1), which obtained the highest sensory score accompanied by increased rose oxide and phenols contents. Regarding Xiahei wine, different treatments had different effects. CFX wines co-fermented in a ratio of 1:3 and 3:1 have prominent aroma compounds. After drying, CXD wines co-fermented in a ratio of 3:1 have a more prominent taste. This research puts forward new innovation points and makes an in-depth analysis and research on specific problems.
Development on an Occupational Performance Questionnaire for Pre-School children with Autistic Spectrum Disorder
Authors: Wallace Kerry , Franzsen Denise , Potterton Joanne 
Published: February 2025

Aim: To describe the development and validation of a low cost parent report measure, the Occupational Performance Questionnaire (OPQ) used to assess the occupational performance areas of personal management, play, and social skills in children with Autism Spectrum Disorder (ASD) as well as the impact, of the child's inability to perform skills in these occupational performance areas, on their families.
Methodology: Preliminary psychometric evaluation was performed on the OPQ. Reliability, content and construct validity as well as convergent validity were determined. The OPQ was field tested with 19 preschoolers with ASD receiving weekly occupational therapy over a one year period.
Results: Psychometric analysis confirmed content and construct validity and test-retest reliability, internal consistency in areas of OPQ:Occupational Performance Areas- personal management (sleeping, feeding, toilet training), play, communication, social interaction and OPQ:Family Impact. The subscales were all sensitive to changes in performance. While the Play and Interaction subscale had moderate convergence with the Short Sensory Profile (SSP) the association with the Personal Management and Communication subscale was weak. The OPQ:Family Impact had moderate convergent validity with the Parent Stress Index (PSI-SF).
Conclusions: The OPQ is a low-cost, valid and reliable outcome measure for evaluating the efficacy of change in occupational performance skills in preschool children with ASD in South Africa.
Gênero, segurança alimentar e nutricional e cidadania: uma análise da intersecção entre mulheres, alimentos e pandemia
Authors: Camargo Sansão Eduarda 
Published: February 2025

Este artigo tem como objetivo avaliar a questão da segurança alimentar na perspectiva da cidadania das mulheres, identificando as particularidades dessa intersecção durante a pandemia Covid-19. A pesquisa justifica-se pela necessidade de explorar as demandas femininas relacionadas ao direito à alimentação, contribuindo para a efetivação de sua cidadania social, política e econômica, diante dos impactos jurídicos, políticos e sociais. Utilizou-se o método hipotético-dedutivo em uma pesquisa descritiva, com recorte temporal entre 2020 e o primeiro semestre de 2022. A metodologia abrangeu revisão bibliográfica e análise documental, com base em produções teóricas e documentos de organizações internacionais, como a Organização das Nações Unidas para Alimentação e Agricultura e a Rede Brasileira de Pesquisa em Soberania e Segurança Alimentar e Nutricional. A análise demonstrou que as demarcações de gênero influenciam a insegurança alimentar, comprometendo a dignidade humana das mulheres e destacando a necessidade de ações para garantir seu direito à alimentação adequada.
O ônus da prova na arbitragem
Authors: Gebran Luiza de Macedo , Ribeiro Marcia Carla Pereira 
Published: February 2025

Este artigo tem como objetivo estabelecer qual regra deve ser aplicada no âmbito arbitral em relação ao ônus da prova, dada a importância da produção de provas nesse método alternativo de resolução de disputas. O objetivo principal é compreender as regras e definir a mais adequada para a aplicação. Foi utilizado o método dedutivo, baseado na revisão bibliográfica de textos principiológicos e manuais de arbitragem, além da análise qualitativa de decisões de anulação de sentenças arbitrais devido à distribuição do ônus probatório. Como resultado, foram estabelecidos indicadores para a decisão sobre as regras do ônus da prova. Primeiramente, o ônus da prova deriva do Princípio do Devido Processo Legal. Em segundo lugar, analisam-se os efeitos o ônus da prova no procedimento arbitral. Em terceiro, avalia-se a aplicabilidade da regra Actori Incumbit Probatio. Em quarto, destaca-se a necessidade de um estudo comparativo entre as tradições do common law e do civil law. Por fim, conclui-se que a aplicação da regra Actori Incumbit Probatio é a mais adequada para o procedimento arbitral, reduzindo os riscos de anulação da sentença arbitral.
Molecular docking in the study of the interaction between cholera toxin subunit B and lipid raft components
Authors: Andrievskaya I. A. , Timkin P. D. , Ustinov E. M. 
Published: February 2025

The aim of this study was to predict, using molecular docking, the formation of complexes between cholera toxin subunit B (CTB) and lipid raft components – gangliosides GM1 and GM3, lactosylceramide (LacCer), and cholesterol. Material and methods. The study involved modeling the three-dimensional structure of the lipid raft–CTB complex to obtain information on ligand coordinates and binding energy, analysis of the amino acid sequences of the CTB D-chain, and molecular docking. Results. Three-dimensional structures of the complexes were obtained using molecular docking. The topology of ligands GM1, GM3, and cholesterol in the molecular pocket of the CTB D-chain was proposed. It was shown that the conformations of CTB with GM1, GM3, and cholesterol ligands exhibited negative binding energy, indicating the potential formation of stable complexes. LacCer was an exception, as its chemical characteristics, associated with the formation of unstable conformers, rendered it unsuitable for docking analysis. Conclusions. The proposed algorithms lay a scientific foundation for solving important applied problems in bioinformatics and pharmacology, specifically in the study of the pathogenesis and treatment of diseases related to lipid raft dysfunction.
Comparative analysis of medical and social characteristics of women with malignant and benign breast neoplasms: the impact of medical and social determinants of public health
Authors: Sukhov A. A. , Cherkasov S. N. , Russkikh S. V. , Fedyaeva A. V. , Saidov S. S. , Tarasenkо Е. А. 
Published: February 2025

Medical and social determinants of public health influence the state of health, risk of occurrence and outcomes of breast neoplasms in women. The aim of the study is a comparative analysis of medical and social characteristics of women with malignant and benign breast neoplasms. Material and Methods. The data of a survey of 600 female patients were used. The main group (women with malignant breast neoplasms) and the control group (women with benign breast neoplasms) were compared, the data were obtained during the survey and by copying data from medical records. The medico-social attributes were combined into groups. Results and discussion. Despite the fact that the groups are similar in social status and lifestyle, data on the presence of evidentiary differences between them in the main groups of characteristics (four groups of characteristics were taken into account: “Obstetric history”; “Morbidity”; “Social status”; “Lifestyle”) were obtained. Conclusions. The social trait “loneliness” through obstetric history is associated with the incidence of breast malignancy. Screening in groups of women with malignant and benign breast neoplasms should be conducted separately, taking into account the social determinant – the social and economic conditions in which they live and are treated, and also in the context of the medical determinant, which includes consideration of the level of professional competence of medical personnel who diagnose and treat these diseases.
Developing Undergraduate Critical Thinking Skills in Mechanics through the Use of Case Method-Based Teaching Materials with QR Code Videos
Authors: Defianti Aprina , Sutarno Sutarno , Johan Henny 
Published: February 2025

This research aims to evaluate the effectiveness of using case method-based teaching materials with QR code videos on undergraduate students' critical thinking skills in mechanics. This research used a quasi-experimental method with a post-test-only control group design. A sample of 2 classes was taken using a purposive sampling technique. The experimental class used case method-based mechanics teaching materials and videos in QR codes, while the control class used print-outs of material summaries. Data collection was carried out through observation and critical thinking skills tests. Critical thinking skills test results data were analyzed using descriptive and inferential statistics. The t-test of two independent non-homogeneous samples is used to test the hypothesis of differences in means. The t-test results showed a difference in the average critical thinking skills scores of experimental and control class students with , greater than at (rounded up to 43). Based on these results, using case method-based mechanics teaching materials and videos in QR codes effectively develops students' critical thinking skills with an effectiveness level of 0.82, which means highly influential.
ESG AND BANKING PERFORMANCE IN EMERGING AND DEVELOPING COUNTRIES: DO ISLAMIC BANKS PERFORM BETTER?
Authors: Fakhrunnas Faaza , Kenc Turalay , Hengchao Zhang 
Published: February 2025

This paper investigates the effects of Environmental, Social, and Governance (ESG) implementation on banking performance in emerging and developing countries. Applying the Two-step System Generalized Method of Moments (System-GMM) to panel data of 179 banks across 29 countries spanning 2016-2022, we find that ESG implementation significantly enhances overall banking profitability. However, when we assess the implications of ESG on Islamic banks, we find that overall ESG commitment significantly reduces profitability. As for the individual ESG pillar, we note the profit-enhancing effect of environmental pillar on both Islamic and conventional bank profitability. Some evidence is also uncovered for the significant positive effect of social pillar on conventional bank profitability. Finally, we note no significant influences from governance pillar. These results highlight the divergent impacts of ESG implementation on Islamic and conventional banks. We conclude that policymakers should exercise caution in designing and implementing ESG policies, ensuring they are tailored to promote optimal performance across different banking models. This study contributes to the growing body of the literature on sustainable finance and provides valuable insights for regulators and bank managers in emerging and developing economies.
Toward a Renewables-Driven Industrial Landscape: Evidence on investment decisions in the Chemical and Steel Sectors
Authors: Quitzow Rainer , Eicke Laima 
Published: February 2025

Abstract

Renewable hydrogen can decarbonize energy-intensive industries like chemicals and steel. This article demonstrates that this shift will likely alter the geography of climate-friendly industrial production. Prior theoretical debates suggest a “renewables pull effect,” where industries relocate to areas with high renewable energy potential. This study provides empirical evidence from a survey of managers at the 50 largest chemical and steel companies worldwide. The results indicate that renewable energy potential will drive locational investment decisions in these sectors by 2050. Additionally, the paper examines the role of industrial policy frameworks and geopolitical developments in these investment decisions, analyzing sectoral and regional specifics. The findings contribute to academic debates on the geopolitics of decarbonization and are relevant to industry and policy decision-makers involved in industrial decarbonization.
Transcriptional Atlas of Cardiac Disease
Authors: Meijers Wouter , Yousif Laura , Sijtema Aukje , Mayr Manuel , Silljé Herman , Thum Thomas , de Boer Rudolf 
Published: February 2025

Abstract

Cardiovascular diseases (CVD), including diseases of the cardiac muscle (cardiac disease), account for a substantial proportion of global morbidity and mortality. Although there are several life-saving drugs and devices that have improved the prognosis, the improvement in the last decade has stabilized, largely because there are no or very few targeted treatments in the combat against CVD. In search for a better understanding of CVD and new therapeutic targets, basic and mechanistic studies are warranted. One important tool is the use of single-cell and single-nucleus RNA sequencing (snRNAseq) approaches. Several individual diseases and specific phenotypes have been studied in this way, but efforts to pool all of this data into one comprehensive dataset are lacking. We created the first human cardiac disease reference atlas so far, encompassing snRNAseq data from 7 datasets, spanning 8 different cardiac diseases (n=117) and healthy tissues (n=37), with over 1.6 million nuclei. This database integrated datasets of cardiac tissue from patients with atrial fibrillation (AF), acute myocarditis (AM), ischemic heart disease (IHD), myocardial infarction (MI), ACM (arrhythmogenic cardiomyopathy), DCM (dilated cardiomyopathy), HCM (hypertrophic cardiomyopathy) and NCM (noncompaction cardiomyopathy). We revealed transcriptional disparities dividing the diseases into acquired cardiac diseases and (genetic) cardiomyopathies, which was supported by pathway analyses based on the differentially expressed genes. Hallmarks of acquired cardiac diseases were dysregulated cellular communication and motility processes, and a strong proof for the cardiac fibroblast as a central mediator. Cardiomyopathies on the other hand were accompanied by processes involved in the contractile function of the heart, with a high contribution of cardiomyocytes. Employing the novel cardiac atlas to explore if repurposing of drugs may be useful, it was revealed that prime targets for fibroblasts (ENO2) and cardiomyocytes (HTR5A) exist. In summary, this atlas represents an important step in cardiac research by recapitulating analyses from various distinct studies and presenting a novel way of gaining insights on multiple cardiac diseases simultaneously.
Exploring the effects of tree presence on maize pest damages, seed health, grain yield, nutritive value, and nutraceutical compounds
Authors: Finocchi Matteo , Ripamonti Alice , Mantino Alberto , Cella Fabrizio Giuseppe , Cesarini Marco , Sarrocco Sabrina , Castagna Antonella , Ricciardi Renato , Lauro Alessandra Di , Mele Marcello , Serra Andrea 
Published: February 2025

Abstract

The present study evaluates the effects of tree presence in an agroforestry system on maize performance, focusing on yield, nutritive value, fatty acid composition, and resistance to biotic stresses. Two maize hybrids, FAO C300 and FAO C500, were cultivated (i) in the narrow alleys of an agroforestry alley-cropping system based on SRC poplar tree rows and (ii) in a treeless control system. In 2023, the results indicate that tree presence does not reduce the average grain yield. However, a significant interaction between systems and maize hybrids was observed. FAO C500 demonstrated superior adaptability to the agroforestry environment, likely due to its longer growth cycle and more developed leaf and root systems, which allow for better resource utilization under water stress conditions. Tree presence did not affect the fatty acid profile of the grains, although FAO C500 accumulated more linoleic acid, while FAO C300 showed higher levels of oleic acid. The agroforestry environment reduced seed infestation by Aspergillus niger, particularly in the FAO C500 hybrid, but increased damage by insects on ear surfaces. These findings highlight the variability in maize hybrid suitability for agroforestry; however, since these results are based on only one year of experimentation, further trials over multiple years are necessary to validate these findings and gain a deeper understanding of tree effects on maize performance.