bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of Antioxidant Properties of Three Naturally Isolated Microalgae: Identification and Bioinformatics Evaluation of the Most Efficient Strain
Authors: Morowvat Mohammad Hossein , Goharian Sara , Ghasemi Younes 
Published: June 2019

Background and Objectives:
In this study, three naturally isolated species of microalgae were investigated for their antioxidant activity using DPPH assay and polyphenol contents through Folin-Ciocalteu analysis.

Methods:
Three different solvents including hexane, ethyl acetate and water, which present different
polarities were utilized to extract the bioactive components from three different microalgal
strains.

Results:
The investigated species exhibited considerable amounts of antioxidants (25.88 ± 0.48
µmol Trolox g-1 in Scenedesmus obliquus) and polyphenol compounds (27.14 ± 0.40 mg GAE g-1
in Chlorella vulgaris). The observed correlation coefficient (R2=0.8265) between the two studied
parameters confirmed the great contribution of the phenolic compounds in the observed antioxidant
activities.

Conclusion:
The phylogenetics and other bioinformatic tools were confirmed as a useful method
for identification of the most prominent species. The obtained data and patents warrant the potentials
of naturally isolated microalgal strains for obtaining different antioxidant and polyphenolic
bioactive compounds.
A Recommendation Approach Using Forwarding Graph to Analyze Mapping Algorithms for Virtual Network Functions
Authors: Bouali Lyes , Khebbache Selma , Bouzefrane Samia , Daoui Mehammed 
Published: June 2019

Background:Network Functions Virtualization (NFV) is a paradigm shift in the way network operators deploy and manage their services. The basic idea behind this new technology is the separation of network functions from the traditional dedicated hardware by implementing them as a software that is able to run on top of general-purpose hardware. Thus, the resulting pieces of software are called Virtual Network Functions (VNFs). NFV is expected, on one hand, to lead to increased deployment flexibility and agility of network services and, on the other hand, to reduce operating and capital expenditures. One of the major challenges in NFV adoption is the NFV Infrastructure's Resource Allocation (NFVI-RA) for the requested VNF-Forwarding Graph (VNF-FG). This problem is named VNF-forwarding graph mapping problem and is known to be an NP-hard problem.Objective:To address the VNF-FG mapping problem, the objective is to design a solution that uses a meta-heuristic method to minimize the mapping cost.Methods:To cope with this NP-Hard problem, this paper proposes an algorithm based on Greedy Randomized Adaptive Search Procedure (GRASP), a cost-efficient meta-heuristic algorithm, in which the main objective is to minimize the mapping cost. Another method named MARA (Most Available Resource Algorithm) was devised with the objective of reducing the Substrate Network’s resources use at the bottleneck clusters.Results:The Performance evaluation is conducted using real and random network topologies to confront the proposed version of GRASP with another heuristic, existing in the literature, based on the Viterbi algorithm. The results of these evaluations reveal the efficiency of the proposed GRASP ‘s version in terms of reducing the cost mapping and performs consistently well across all the evaluations and metrics.Conclusion:The problem of VNF-FG mapping is formalized, and a solution based on GRASP meta- heuristic is proposed. Performance analysis based on simulations are given to show the behavior and efficiency of this solution.
ОСОБЛИВОСТІ ТОЛЕРАНТНОСТІ ДО ФІЗИЧНИХ НАВАНТАЖЕНЬ В ПОСТІНФАРКТНОМУ ПЕРІОДІ В ЗАЛЕЖНОСТІ ВІД НАЯВНОСТІ ДЕКОМПЕНСАЦІЇ ХРОНІЧНОЇ СЕРЦЕВОЇ НЕДОСТАТНОСТІ
Authors: Вакалюк І. П. , Левандовська Х. В. 
Published: June 2019

Резюме. Ціль. Оцінити фізичну активність та доцільність використання тесту шестихвилинної ходьби у хворих з декомпенсованою СН у ранньому та пізньому постінфарктному періоді на фоні показників натрійуретичного пропептиду типу В.
Матеріали і методи дослідження. Було обстежено 160 пацієнтів з перенесеним інфарктом міокарда. Хворих було рандомізовано в 2 групи, залежно від наявності ознак декомпенсованої хронічної СН. Досліджені групи були однорідними за віком, статтю, важкістю перебігу захворювання, тривалістю постінфарктного періоду, наявністю клінічних проявів декомпенсації.
Результати дослідження та їх обговорення. Впродовж вивчення клінічних та електрокардіологічних ознак виконання фізичних навантажень, таких як депресія сегменту ST, стенокардія, задишка, симптоми з боку центральної нервової системи, було виявлено значне погіршення стану пацієнтів з діагнозом Q-QS та не-Q ІМ, ускладненим декомпенсованою СН. У результаті аналізу ТШХ було з’ясовано, що наявність декомпенсованої СН значно погіршує показники цієї навантажувальної проби. В осіб з ознаками декомпенсованої СН мали місце вірогідно вищі рівні NT–proBNP у сироватці крові і склали (850,54±20,51)пг/мл (p≤0,05) в порівнянні з першою групою (428,5±6,81) пг/мл (p≤0,05).
Висновки. У ході роботи встановлено, що неадекватна відповідь на дозовані фізичні навантаження, високий рівень NT–proBNP можуть бути корисними не тільки для ранньої діагностики та прогнозування виникнення декомпенсованої СН в ранньому та пізньому постінфарктному періоді, але і для прийняття рішення про оптимальне подальше диспансерне лікування такого контингенту хворих та рішення про виписку після госпіталізації.
PILOT STUDIES OF PROCESS OF VIBROACOUSTIC DYNAMICS AT LOCAL HARDENING OF DETAILS A SHARIKO-ROD UPROCHNITEL
Authors: Morozov S. A. , Chukarin A. N. 
Published: June 2019

Objectives The most important problem of modern mechanical engineering is increase in durability of products, their efficiency and competitiveness in the world market. The equipment for machining creates the increased noise levels in a working zone of operators. Now regularities of formation of acoustic characteristics are studied generally for metal-cutting and woodworking machines of various types. Formation of the sound field at shariko-rod hardening is studied insufficiently. The purpose of researches which results are given in this article consisted in studying of regularities of spectral structure of noise and vibrations when processing ShSU of details with various ways of fixing. Method. In the course of pilot studies the known methods of measurement and processing of experimental data in relation to acoustic and vibration characteristics were used. Results. It is established that noise ranges at ShSU of details with various ways of fixing have identical regularities of a shumoobrazovaniye and are characterized by pronounced high-frequency character. It is proved that the dominating sources yaa-lyatsya the strengthened detail and an uprochnitel. Conclusion. Sizes of excesses of levels of sound pressure systems "up-rochnitel-detal2 in a high-frequency part of a range 500-8000gts are installed. The established regularities of formation of spectral structure are a basis for the choice of means of decrease in noise levels. Work is performed within initiative research work.
El voto electrónico en la construcción de un modelo de democracia electrónica
Authors: Hernández Trejo Ninfa Elizabeth 
Published: June 2019

<p>El objetivo de este trabajo es presentar una propuesta de modelo de democracia electrónica a partir del uso político de la tecnología, particularmente del voto electrónico. Para ello, se analiza el empleo del voto electrónico en mecanismos de participación ciudadana, con lo cual es posible contribuir a la democracia electrónica, pues a diferencia de cuando se utiliza en procesos electorales, en éstos el votante se involucra en decisiones más elaboradas, como el destino del gasto público o el proceso legislativo; y lo puede lograr apoyándose de la tecnología para<br />generar canales de información, deliberación y toma de decisión</p>
Research of the toolkit features for the evaluation and development of project-oriented management in a full cycle engineering company
Authors: Kudrevatykh Vladimir V. 
Published: June 2019

Introduction. Analysis of existing foreign and Russian project management maturity models revealed the absence of tools for assessing the maturity of project management, which would take into account the specifics of the functioning of engineering companies and the implementation of engineering projects. The uniformity of such models limits the list of evaluated aspects of project management, which does not allow to fully cover the project management processes operating in engineering companies. Such processes should include engineering, management of intangible assets, control and acceptance of the results of engineering works, management of construction and installation works, and so on. To solve the problem, it is necessary to develop special tools for the assessment and development of project management, which will take into account engineering-specific processes. The toolkit will allow to quantify the degree of implementation of the project approach to the activities of an engineering company and to plan the continuous improvement of the processes and tools of project management in it. The subject of the research is the development of tools for assessing and developing project-oriented management in a full-cycle engineering company.
Materials and methods. Applied the method of comparative analysis, survey method and method of semi-structured interviews.
Results. The article formulates the features of project management in engineering companies. The main types of maturity models of project management are considered, their distinctive features are revealed. Tools for the evaluation and development of project management for the Russian engineering company full cycle are formulated. The assessment of the levels of formalization of project management processes was carried out, their current and target states were determined. Set of measures for the development of processes and tools of project management is planned.
Conclusions. The toolkit for project management evaluation and development proposed in the article allows to carry out structural analysis of project management processes and the level of their formalization, to implement improvements based on the results of evaluation not only in the engineering company under consideration, but also in project-oriented organizations implementing similar projects.
المدخل الاتصالي في تعليم اللغة العربية
Authors: Asy’ari Hasyim 
Published: June 2019

Humans need language in order to interact with society. They express their thoughts and intentions with language. Language is a communication tool in society. And learning a foreign language not only learns grammar, but the ability to communicate with other communities. The approach that fits this purpose is the communicative approach. Communicative is the process of conveying thoughts and perceived by speech methods that include meaningful writing and a clear subject of thought. This approach aims to develop language competence in general by directing learners to language functions. Communicative ability is one's ability to grammatical adjustment and its use for certain communicative functions with cra corresponding to a particular place.
PERILAKU KOMUNIKASI PENGGUNA AKTIF INSTAGRAM
Authors: Nugraha Bayu , Akbar M. Fakhrudi 
Published: June 2019

Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang melatarbelakangi terjadinya perilaku komunikasi pengguna aktif Instagram dan mengetahui perilaku komunikasi antar sesama pengguna aktif Instagram. Penelitian ini menggunakan metode kualitatif studi kasus. Teknik pengumpulan data menggunakan wawancara berulang kepada delapan orang informan, observasi, studi pustaka serta analisis dokumen yang berkaitan dengan penelitian ini. Hasil dari penelitian ini mengungkapkan bawah faktor-faktor yang melatarbelakangi terjadinya perilaku komunikasi pengguna aktif instagram adalah fasilitas pendukung, keinginan untuk menghasilkan karya yang lebih baik, frekuensi mengakses yang tinggi serta dorongan kerabat. Perilaku komunikasi antar sesama pengguna aktif instagram yaitu mengunggah foto, melakukan following dan unfollow, memberikan like dan komentar, membubuhi informasi pada foto yang diunggah serta menghadiri kegiatan gathering dan photowalk.
Effect of a two-base insertion mutation of the TP53 gene on expression of p53 protein in canine histiocytic sarcoma cells
Authors: Asada Hajime , Tomiyasu Hirotaka , Goto-Koshino Yuko , Ohno Koichi , Tsujimoto Hajime 
Published: June 2019

Abstract

OBJECTIVE
To examine effects of a common mutation (2-base insertion in exon 5) of the TP53 gene on biological function of p53 protein in canine histiocytic sarcoma cells.

SAMPLE
Canine histiocytic tumor cell lines DH82 with deletion of TP53 and CHS-3 with the wild-type TP53 and canine wild-type and mutant TP53 fragments.

PROCEDURES
Wild-type or mutant TP53 with a polyprotein peptide tag at the N-terminus was transduced into DH82 and CHS-3 cells. Expression of p53 protein, changes in function as a transcription factor, and susceptibility to doxorubicin and nimustine were compared.

RESULTS
Transduced p53 protein was detected in wild-type TP53–transduced DH82 and CHS-3 cells, whereas expression was not detected in mutant TP53–transduced cells. There were significant increases in expression of target genes of p53 protein, including p21 and MDM2, in wild-type TP53–transduced cells, compared with results for native and mock-transfected cells, but not in mutant TP53–transduced cells. There was no significant difference in drug susceptibilities among native and derivative cells of CHS-3. However, cell viabilities of wild-type TP53–transduced DH82 cells incubated with doxorubicin were significantly lower than viabilities of native, mock-transfected, and AT insertion mutation–TP53–transduced DH82 cells; susceptibility to nimustine did not differ significantly among cells.

CONCLUSIONS AND CLINICAL RELEVANCE
Expression of p53 protein and its function as a transcription factor were lost after addition of a 2-base insertion in the TP53 gene in canine histiocytic tumor cells. Additional studies are needed to investigate the clinical relevance of this mutation in histiocytic sarcomas of dogs.
AKR1D1*36 C>T (rs1872930) allelic variant is associated with variability of the CYP2C9 genotype predicted pharmacokinetics of ibuprofen enantiomers – a pilot study in healthy volunteers
Authors: Kapedanovska Nestorovska Aleksandra , Jakjovski Krume , Naumovska Zorica , Sterjev Zoran , Geskovska Nadica Matevska , Mladenovska Kristina , Suturkova Ljubica , Dimovski Aleksandar 
Published: June 2019

Abstract
The relative contribution of CYP2C9 allelic variants to the pharmacokinetics (PK) of ibuprofen (IBP) enantiomers has been studied extensively, but the potential clinical benefit of pharmacogenetically guided IBP treatment is not evident yet. The role of AKR1D1*36C>T (rs 1872930) allelic variant in interindividual variability of CYP450 mediated drug metabolism was recently elucidated. A total of 27 healthy male subjects, volunteers in IBP single-dose two-way cross-over bioequivalence studies were genotyped for CYP2C9*2, CYP2C9*3 and AKR1D1*36 polymorphisms. The correlation between CYP2C9 and AKR1D1 genetic profile and the PK parameters for S-(+) and R-(−)-IBP was evaluated. Remarkable changes in the PK values pointing to reduced CYP2C9 enzyme activity were detected only in the CYP2C9*2 allelic variant carriers. Statistically significant association between the AKR1D1*36 allele and the increased IBP metabolism (low AUC
0-t and 0–∞, high Cl
tot and short t
max values for both enantiomers) was observed in subjects carrying the CYP2C9 *1/*3 or CYP2C9*1/*1 genotype. The clinical value of concomitant CYP2C9 and AKR1D1 genotyping has to be further verified.
Dual skew Heyting almost distributive lattices
Authors: Assaye Berhanu , Alamneh Mihret , Mishra Lakshmi Narayan , Mebrat Yeshiwas 
Published: June 2019

Abstract
In this paper, we introduce the concept of dual skew Heyting almost distributive lattices (dual skew HADLs) and characterise it in terms of dual HADL. We define an equivalence relation θ on a dual skew HADL L and prove that θ is a congruence relation on the equivalence class [x]θ so that each congruence class is a maximal rectangular subalgebra and the quotient [y]θ/θ is a maximal lattice image of [x]θ for any y ∈ [x]θ. Moreover, we show that if the set PI (L) of all the principal ideals of an ADL L with 0 is a dual skew Heyting algebra then L becomes a dual skew HADL. Further we present different conditions on which an ADL with 0 becomes a dual skew HADL.
Multiplicative topological descriptors of Silicon carbide
Authors: Virk Abaid ur Rehman , Abbas Tanveer , Khalid Wasim 
Published: June 2019

Abstract
Topological indices helps us to collect information about algebraic graphs and gives us mathematical approach to understand the properties of chemical structures. In this paper, we aim to compute multiplicative degree-based topological indices of Silicon-Carbon Si
2
C
3
−III[p,q] and SiC
3
−III[p,q] .
Finding Hidden Structures, Hierarchies, and Cores in Networks via Isospectral Reduction
Authors: Bunimovich Leonid , Smith Dallas , Webb Benjamin 
Published: June 2019

Abstract
The method of isospectral network reduction allows one the ability to reduce a network while preserving the network’s spectral structure. In this paper we describe a number of recent applications of the theory of isospectral reductions. This includes finding hidden structures, specifically latent symmetries, in networks, uncovering different network hierarchies, and simultaneously determining different network cores. We also specify how such reductions can be interpreted as dynamical systems and describe the type of dynamics such systems have. Additionally, we show how the recent theory of equitable decompositions can be paired with the method of isospectral reductions to decompose networks.
Steady flow of a power law fluid through a tapered non-symmetric stenotic tube
Authors: Ahmad Riaz , Farooqi Asma , Zhang Jiazhong , Ali Nasir 
Published: June 2019

Abstract
A steady flow of a power law fluid through an artery with a stenosis has been analyzed. The equation governing the flow is derived under the assumption of mild stenosis. An exact solution of the governing equation is obtained, which is then used to study the effects of various parameters of interest on axial velocity, resistance to flow and shear stress distribution. It is found that axial velocity increases while resistance to flow decreases when going from shear-thinning to shear-thickening fluid. Moreover, the magnitude of shear stress decreases by increasing the tapering parameter. This problem was already addressed by Nadeem et al. [14], but the results presented by them were erroneous due to a mistake in the derivation of the governing equation of the flow. This mistake is highlighted in the "Formulation of the Problem" section.
EU Project of Life Programme “Algae Service for Life” Creates Tools for Ecological Service to Mitigate Cyanobacteria and Macroalgae Blooms in Freshwater Ecosystems
Authors: Koreivienė Judita , Karosienė Jūratė , Kasperovičienė Jūratė , Paškauskas Ričardas , Messyasz Beata , Łęska Bogusława , Pankiewicz Radosław , Gulbinas Zenonas , Valskys Vaidotas , Walusiak Edward , Krzton Wojciech , Kustosz Dominika , Wilk-Woźniak Elźbieta 
Published: June 2019

AbstractEU international project of LIFE programme “Algae Service for LIFE” seeks to promote best practices in ecological service and development of circular economy. The goal of the project is to demonstrate integrated efficient management of nutrients and nuisance algal blooms at the catchment scale by harvesting cyanobacteria scums and macroalgae mats in various types of water bodies (rivers, lakes and estuarine lagoon). Also, it seeks to raise awareness of the national and local authorities, business community and society on the environmental, water quality and health hazard issues. The paper provides the idea of applying ecological measures to control algal blooms. Thus, issues related to the causes and mechanisms of eutrophication in inland freshwaters as well as to consequences such as algal blooms are highlighted. The measures proposed in the project are briefly discussed in the light of European Union directives.
Hybrid Time-Base Device for Coherent Sampling Oscilloscope
Authors: Tankeliun Tomas , Zaytsev Oleg , Urbanavicius Vytautas 
Published: June 2019

Abstract
In this paper, a hybrid time-base (HTB) device for the coherent sampling oscilloscope is presented. The HTB device makes it possible to reduce the uncertainty of determining the time position of the sample in the horizontal channel of the sampling oscilloscope. For its functioning, the proposed HTB device requires that the system-under-test, in addition to the test signal, also has a synchronous reference clock – harmonic oscillation. It should be noted that both the test signal and the harmonic reference clock are sampled simultaneously. The harmonic reference clock is connected to one of the oscilloscope channels and a special algorithm processes the clock samples and adjusts the coherent sampling mode. Two techniques of determining the position of the sample on the time axis are combined in the HTB device – the “trigonometric”, when the position is calculated by the arccosine or arcsine formula of the reference clock sampling value, and the interpolation method, according to which the time position of the sample is found by averaging the positions of two adjacent samples, obtained using said “trigonometric” technique. Primary experimental studies have shown that using the HTB device can reduce jitter of the sampling oscilloscope by several times and the drift with constant time distortion components is practically absent in this device.
Media disruption and the public interest
Authors: Syvertsen Trine , Donders Karen , Enli Gunn , Raats Tim 
Published: June 2019

Abstract
Digitization, new entrants and the disruption of business models prompt concern about the media’s societal mission. The article investigates how media managers conceptualize societal responsibility in an era of turmoil. Based on 20 semi-structured interviews with executive managers of private media companies in Norway and Flanders, the study reveals important differences in the definition of the public interest. While Flemish media managers emphasize brand value, Norwegian managers emphasize societal values, such as educating the public. When comparing managers of traditional and newer companies, a third, more straightforward market logic is also elicited, illuminating the vulnerability of traditional values.
Disrupting video game distribution
Authors: Werning Stefan 
Published: June 2019

Abstract
This article analyses the disruptive potential of Valve’s game distribution platform, Steam, focusing specifically on how Steam has evolved into a de facto online social network and how Valve uses constant feature changes as part of its corporate rhetoric. Despite its profound influence on the video game industry, scholarly inquiry into Steam has focused on analyses of user or value creation. However, Steam arguably derives its long-term disruptive potential from combining the gamification of digital distribution with the formation of ephemeral public spheres around the games that it distributes, thereby becoming a de facto online social network. To investigate this strategy, the article employs a historically comparative affordance analysis, drawing on a small data set of Steam blog posts and tech blog coverage from 2007 to 2018 to map patterns of affordance change.