bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vergleichende Bewertung der Bodeneigenschaften durch CPT und DMT
Authors: Maček Matej , Logar Janko , Pulko Boštjan 
Published: August 2019

AbstractThe piezocone penetration test (CPT) and flat dilatometer test (DMT) are routinely used in geotechnical practice and are often considered adequate for detailing of soil profile and determination of soil properties. This paper presents comparison of results of ground characterization and evaluation of soil properties based on the combined use of CPT and DMT at four different locations, each with different ground composition. Evaluation of both tests in terms of soil type, undrained shear strength, constrained modulus and friction angle is presented and results are compared. In some cases the results are also compared with laboratory data. The main objective is to show that companion sets of CPT and DMT at a given site could be used to better define the geotechnical ground model and to increase confidence in the evaluation of soil properties.
Scherfestigkeits‐ und Verformungsverhalten von tertiären Böden
Authors: Mahler András , Móczár Balázs 
Published: August 2019

AbstractThis article presents the results of in‐situ and triaxial testing of tertiary soils (Pannonian sand and Oligocene clay) performed for two major Hungarian projects. The shear strength of these formations varies greatly. Just interpreting the shear strength of tertiary soils poses a number of questions, which definitely exceeds the scope of existing standards. Since extracting multiple samples from the overconsolidated, high‐density samples was not possible, the necessary parameters had to be determined from one larger specimen. Through short examples, it is demonstrated how the test results can be described using soil models and transferred into geotechnical design, highlighting the limits of numerical modelling (in case of these soils).
Psychosis of Alzheimer's disease: Neuropsychological and neuroimaging longitudinal study
Authors: D'Antonio Fabrizia , Di Vita Antonella , Zazzaro Giulia , Brusà Erica , Trebbastoni Alessandro , Campanelli Alessandra , Ferracuti Stefano , de Lena Carlo , Guariglia Cecilia , Boccia Maddalena 
Published: August 2019

ObjectivesPsychosis of Alzheimer's disease (AD) may represent a distinct disease phenotype; however, neuropsychological profile and neural basis linked to this phenotype have not yet been clarified. In this study, we aimed at detecting whether impairment in specific cognitive domains predicts the onset of psychosis in AD patients and what grey matter alterations, their location, and the rate of atrophy are associated with psychosis of AD.MethodsLongitudinal neuropsychological data from AD patients with and without psychosis were analysed to determine whether the neuropsychological profile can predict the onset of psychosis. A voxel‐based morphometry (VBM) on longitudinal T1‐weighted images was used to explore differences in grey matter volume and in the rate of atrophy between groups.ResultsNoncognitive domain predicted the psychosis onset. However, AD patients with psychosis exhibited greater atrophy in the right anterior‐inferior temporal lobe, including the fusiform gyrus (cluster‐p‐family‐wise error [pfwe] < 0.05; peak‐p uncorrected [pUNC] < 0.001) as well as greater rate of atrophy in the right insula than nonpsychotic patients (cluster‐pFWE = 0.075; peak‐pUNC < 0.001). The anterior‐inferior temporal lobe is part of the ventral visual stream, and the insula plays a key role in the salience network.ConclusionsThis finding suggests that damage in these areas underpins an impairment in the visual processing of the objects and an impairment in the attribution of salience to the misperceived stimuli, which in turn leads to the onset of psychosis. These findings tie in well with the neuropsychological model of psychosis, according to which the simultaneous presence of two factors, namely misperception and misattribution, underlies psychosis in dementia.
A longitudinal study of the associations of BDNF genotype and methylation with poststroke anxiety
Authors: Kang Hee‐Ju , Kim Kyu‐On , Kim Ju‐Wan , Kim Sung‐Wan , Park Man‐Seok , Kim Hye‐Ran , Shin Myung‐Geun , Cho Ki‐Hyun , Kim Jae‐Min 
Published: August 2019

BackgroundAlthough the precise etiology of poststroke anxiety (PSA) has yet to be fully elucidated, it is known that brain‐derived neurotrophic factor (BDNF) is important for neural plasticity and long‐term potentiation, associated with the pathophysiology of anxiety. The expression of BDNF is regulated by epigenetic and genetic profiles. Thus, we investigated the association between BDNF methylation status and PSA at 2 weeks and 1 year after stroke while accounting for interactions with the BDNF Val66Met polymorphism.MethodsThe baseline sample comprised 286 patients who were assessed at 2 weeks after stroke; of these patients, 222 (78%) were followed up with at 1 year after stroke. The presence of PSA was determined using the anxiety subscale of the Hospital Anxiety and Depression Scale (HADS), and the effects of BDNF methylation status and polymorphisms on PSA status were assessed with multivariate logistic regression models.ResultsThe prevalence of PSA was slightly lower (27 [9.4%]) at baseline, and 35 (15.8%) patients were identified as having PSA at the 1‐year follow‐up. Stroke patients with a higher average methylation status were more likely to have PSA at 1 year. The BDNF Val66Met polymorphism was not independently associated with PSA during either the acute or chronic phase after stroke, but there was a significant interactive effect between BDNF methylation and genotype on PSA at 2 weeks.ConclusionsIn this study, BDNF methylation in combination with the met/met BDNF polymorphism (Val66Met polymorphism) was associated with PSA. These findings may help identify patients at higher risk for PSA.
Lay‐delivered behavioral activation for depressed senior center clients: Pilot RCT
Authors: Raue Patrick J. , Sirey Jo Anne , Dawson Alexis , Berman Jaquelin , Bruce Martha L. 
Published: August 2019

ObjectiveWe describe the development of a lay‐delivered behavioral intervention (“Do More, Feel Better”) for depressed senior center clients, and we present preliminary data from a pilot randomized controlled trial (RCT) on (a) the feasibility of training lay volunteers to fidelity and (b) the acceptability, impact, and safety of the intervention.MethodsWe trained 11 volunteers at two aging service settings in “Do More, Feel Better” and randomized 18 depressed clients to receive the intervention or referral to mental health services.ResultsPilot data indicated that we can successfully train and certify 64% of older volunteers and that depressed clients receiving the intervention reported high levels of session attendance and satisfaction. While there were no significant differences in 12‐week reduction in Hamilton Depression Rating Scale scores between groups, intervention clients showed an 8‐point reduction in comparison with a 0‐point reduction among referral clients.Conclusions“Do More, Feel Better” has the potential of transferring evidence‐based behavioral interventions to the hands of supervised lay volunteers and can address the insufficient workforce providing geriatric mental health services.
Differential development of relational memory and pattern separation
Authors: Hassevoort Kelsey M. , Khan Naiman A. , Hillman Charles H. , Cohen Neal J. 
Published: August 2019

AbstractResearchers have taken a number of different approaches in their exploration of hippocampal function. One approach seeks to describe hippocampal function by probing the memory representations that the hippocampus supports. Another approach focuses on the role of the hippocampus in pattern separation and completion. Each of these approaches to understanding hippocampal function utilizes a distinct set of specialized tasks, and both of these task sets are known to be sensitive to changes in hippocampal function with age and disease status. But the question remains whether the tasks utilized in these two approaches tap into the same aspects of hippocampal function. We explored this question in the context of hippocampal development. Preadolescent children (N= 73) and young adults (N= 41) completed an identical battery of cognitive tasks consisting of a spatial reconstruction relational memory task, the mnemonic similarity task (MST)—an object‐based pattern separation task, and a novel hybrid task—the Object Discrimination and Distribution (ODD) Task—designed to integrate and simultaneously tax pattern separation and spatial relational memory. Children did not demonstrate impairments in lure discrimination relative to young adults on either the object‐based pattern separation task or for aspects of the ODD task that required pattern separation in the absence of relational memory demands but performed more poorly across aspects of tasks that required relational binding.
Effects of continuous care for patients with type 2 diabetes using mobile health application: A randomised controlled trial
Authors: Wang Yanmei , Li Ming , Zhao Xinxiang , Pan Xinxin , Lu Min , Lu Jing , Hu Yan 
Published: August 2019

SummaryBackgroundType 2 diabetes is a worldwide disorder that affects millions of people and can exert negative clinical and social effects on the patients. In some previous studies, mobile health applications have been used as a means of clinical intervention. However, the therapeutic effect of continuous care through mobile phone applications for patients with type 2 diabetes remains unclear.ObjectiveThis study aimed to explore the clinical effect of continuous care for patients with type 2 diabetes using mobile health application by comparing traditional discharge nursing.MethodsIn total, 120 patients with type 2 diabetes were randomly divided into two groups: The test group received continuous care based on the mobile phone application (n = 60), and the control group received conventional care (n = 60). Primary clinical outcomes, such as Glycaemic Haemoglobin (GH) levels, blood glucose levels, self‐care abilities, disease cognition abilities, and the number of readmissions, were examined in both groups.ResultsThe results showed significant improvements pertaining to disease awareness levels (81.28 vs 71.34, P < .05), self‐management abilities (9.14 vs 7.81, P < .05), GH (−1.50% vs −0.76%, P < .05), fast blood glucose (−3.23 vs −1.25 mmol/L, P < .05), postprandial blood glucose levels (−4.34 vs −2.34 mmol, P < .05), and control levels in the test group. Moreover, in the test group, the frequency of rehospitalisation was reduced during the intervention period, as was the average number of rehospitalisation within 6 months after discharge (−1.19 vs P < .05).ConclusionsContinuous care based on a mobile health application has potential as a management strategy for patients with type 2 diabetes.
Exploration and practice of the “1 + 10 + 1100000” model
Authors: Ge Jianli , Geng Shasha , Jing Limei , Jiang Hua , Sun Xiaoming 
Published: August 2019

SummaryThe exploration and practice of the “1 + 10 + 1100000” model of local medical consortium includes three aspects: graded diagnosis and treatment, two‐way referral, and dynamic flow; seamless connection between general practice and specialty to realize health management; and establishment of the “community health center‐East Hospital‐Tongji University” teaching platform.
Conflicting norms: Impact of the Model Law on Chapter 11's Global Restructuring Role
Authors: Warner G. Ray 
Published: August 2019

AbstractThe Model Law's emphasis on the debtor's center of main interest (COMI) as the proper jurisdiction for the main insolvency proceeding is at odds with the traditional United States approach of applying Chapter 11 to restructure foreign entities with no significant US connection. This paper explores whether adoption of the Model Law has made Chapter 11 less available for debtors with a foreign COMI. The Model Law has had no direct impact on the US courts approach to foreign‐entity Chapter 11 cases. However, shortly after the Model Law's adoption, several reported US decisions added the pendency of a foreign insolvency proceeding as a factor supporting discretionary abstention or dismissal of foreign Chapter 11 cases. While those decisions do not refer to the Model Law, it is possible that the Model Law's COMI‐centric approach influenced this new trend.
Hybrid cardiovascular sourced extracellular matrix scaffolds as possible platforms for vascular tissue engineering
Authors: Reid James A. , Callanan Anthony 
Published: August 2019

AbstractThe aim when designing a scaffold is to provide a supportive microenvironment for the native cells, which is generally achieved by structurally and biochemically imitating the native tissue. Decellularized extracellular matrix (ECM) possesses the mechanical and biochemical cues designed to promote native cell survival. However, when decellularized and reprocessed, the ECM loses its cell supporting mechanical integrity and architecture. Herein, we propose dissolving the ECM into a polymer/solvent solution and electrospinning it into a fibrous sheet, thus harnessing the biochemical cues from the ECM and the mechanical integrity of the polymer. Bovine aorta and myocardium were selected as ECM sources. Decellularization was achieved using sodium dodecyl sulfate (SDS), and the ECM was combined with polycaprolactone and hexafluoro‐2‐propanol for electrospinning. The scaffolds were seeded with human umbilical vein endothelial cells (HUVECs). The study found that the inclusion of aorta ECM increased the scaffold's wettability and subsequently lead to increased HUVEC adherence and proliferation. Interestingly, the inclusion of myocardium ECM had no effect on wettability or cell viability. Furthermore, gene expression and mechanical changes were noted with the addition of ECM. The results from this study show the vast potential of electrospun ECM/polymer bioscaffolds and their use in tissue engineering.
System for application of controlled forces on dental implants in rat maxillae: Influence of the number of load cycles on bone healing
Authors: de Barros e Lima Bueno Renan , Dias Ana P. , Ponce Katia J. , Brunski John B. , Nanci Antonio 
Published: August 2019

AbstractExperimental studies on the effect of micromotion on bone healing around implants are frequently conducted in long bones. In order to more closely reflect the anatomical and clinical environments around dental implants, and eventually be able to experimentally address load‐management issues, we have developed a system that allows initial stabilization, protection from external forces, and controlled axial loading of implants. Screw‐shaped implants were placed on the edentulous ridge in rat maxillae. Three loading regimens were applied to validate the system; case A no loading (unloaded implant) for 14 days, case B no loading in the first 7 days followed by 7 days of a single, daily loading session (60 cycles of an axial force of 1.5 N/cycle), and case C no loading in the first 7 days followed by 7 days of two such daily loading sessions. Finite element modeling of the peri‐implant compressive and tensile strains plus histological and immunohistochemical analyses revealed that in case B any tissue damage resulting from the applied force (and related interfacial strains) did not per se disturb bone healing, however, in case C, the accumulation of damage resulting from the doubling of loading sessions severely disrupted the process. These proof‐of‐principle results validate the applicability of our system for controlled loading, and provide new evidence on the importance of the number of load cycles applied on healing of maxillary bone.
Vertebral Fracture Assessment Increases Use of Pharmacologic Therapy for Fracture Prevention in Clinical Practice
Authors: Schousboe John T , Lix Lisa M , Morin Suzanne N , Derkatch Sheldon , Bryanton Mark , Alhrbi Mashael , Leslie William D 
Published: August 2019

ABSTRACT
The impact of vertebral fracture assessment (VFA) on lateral spine images in clinical practice on subsequent patient use of fracture prevention medication is unknown. Our objective was to determine the association of prevalent vertebral fracture identified on bone density lateral spine images (positive VFA) with subsequent use of fracture prevention therapy in usual clinical practice, using the Manitoba Bone Density Program database prospective observational cohort. Since 2010, targeted VFA imaging has been done at the time of bone densitometry in Manitoba for 21% of women and men meeting criteria based on age, bone mineral density (BMD), height loss, and glucocorticoid use. Among 6652 treatment-naive individuals with at least 90 days follow-up who had VFA imaging, 923 (13.9%) had one or more definite vertebral fractures identified using a modified algorithm-based qualitative (ABQ) method. For those with a positive VFA, their bone density reports stated the patient was at high risk of subsequent fracture and qualified for fracture prevention therapy. Subsequent osteoporosis treatment initiated within the next 12 months was identified using population-based pharmacy data. Logistic regression models were used to estimate the association of positive VFA with subsequent prescription (Rx), compared to negative VFA. Fracture prevention medication was started by 2127 (32%) individuals, 52.3% with positive versus 28.4% with negative VFA (p value &lt;0.001). This association was substantially stronger in those designated (before VFA results were known) to have low or moderate fracture risk compared to high fracture risk (interaction p value &lt;0.001), and in those with osteopenia (OR 4.51; 95% CI, 3.48 to 5.85) compared to those with osteoporosis by BMD criteria (OR 1.72; 95% CI, 1.43 to 2.08, interaction p value &lt;0.001). Targeted VFA imaging at the time of bone densitometry substantially improves identification of those at high fracture risk and fracture prevention medication use among those with prevalent vertebral fracture. © 2019 American Society for Bone and Mineral Research. © 2019 American Society for Bone and Mineral Research.
Interrater agreement and discrepancy when assessing problem behaviors, social‐emotional skills, and developmental status of kindergarten children
Authors: Bergold Sebastian , Christiansen Hanna , Steinmayr Ricarda 
Published: August 2019

AbstractObjectiveThe present study examined parent‐teacher agreement and discrepancy when assessing kindergarten children's behavioral and emotional problems, social‐emotional skills, and developmental status.MethodParents and teachers of overall n = 922 kindergarten children (M
age = 3.99; 449 girls) rated the children using the Conners Early Childhood, the Strengths and Difficulties Questionnaire, and the Questionnaire for Assessing Preschool Children's Behavior.ResultsAgreement was moderate for problem behaviors and social‐emotional skills and substantial for developmental status. Agreement was stronger for externalizing than for internalizing problems. Agreement on the clinical relevance of problem behaviors and of social‐emotional skills was stronger for children with a clinical diagnosis than for those without. Parents tended to report more problems, but also greater social‐emotional skills and developmental status, than teachers.ConclusionsThe findings corroborate the importance of situational specificity for understanding interrater agreement and discrepancy. Future teacher questionnaires should more specifically assess children's functioning in kindergarten.
Getting youth PrEPared: adolescent consent laws and implications for the availability of PrEP among youth in countries outside of the United States
Authors: Taggart Tamara , Bond Keosha T , Ritchwood Tiarney D , Smith Justin C 
Published: August 2019

AbstractIntroductionYouth under the age of 25 are at high risk for HIV infection. While pre‐exposure prophylaxis (PrEP) has the potential to curb new infections within this population, it is unclear how country‐specific laws and policies that govern youth access to sexual and reproductive health (SRH) services impact access to PrEP. The purpose of this review was to analyse laws and policies concerning PrEP implementation and SRH services available to youth in countries with a high HIV incidence. To the best of our knowledge this is the first systematic assessment of country‐level policies that impact the availability of PrEP to adolescent populations.MethodsWe conducted a review of national policies published on or before 12 June 2018 that could impact adolescents’ access to PrEP, SRH services and ability to consent to medical intervention. Countries were included if: (1) there was a high incidence of HIV; (2) they had active PrEP trials or PrEP was available for distribution; (3) information regarding PrEP guidelines were publicly available. We also included a selected number of countries with lower adolescent HIV incidence. Internet and legal database searches were used to identify policies relevant to adolescent PrEP (e.g. age of consent to HIV testing).Results and DiscussionFifteen countries were selected for inclusion in this review. Countries varied considerably in their respective laws and policies governing adolescents’ access to PrEP, HIV testing and SRH services. Six countries had specific polices around the provision of PrEP to youth under the age of 18. Five countries required people to be 18 years or older to access HIV testing, and six countries had specific laws addressing adolescent consent for‐ and access to‐ contraceptives.ConclusionsAdolescents’ access to PrEP without parental consent remains limited or uncertain in many countries where this biomedical intervention is needed. Observational and qualitative studies are needed to determine if and how adolescent consent laws are followed in relation to adolescent PrEP provisions. Intensified efforts to amend laws that limit adolescent access to PrEP and restrict the establishment of national guidelines supporting adolescent PrEP are also needed to address the epidemic in this group.
Etesians and the summer circulation over East Mediterranean in Coupled Model Intercomparison Project Phase 5 simulations: Connections to the Indian summer monsoon
Authors: Logothetis Ioannis , Tourpali Kleareti , Misios Stergios , Zanis Prodromos 
Published: August 2019

AbstractEtesians are north to south direction winds in the lower atmosphere, blowing over the Aegean basin from early summer to early autumn. They are an important circulation component for the East Mediterranean (EMED) area, linked to the subsidence and ascent circulation over EMED and the extended Indian monsoon region, respectively. In this study we investigate the evolution of Etesian days and the associated wind speed (10 m) over the recent past (1979–2005) in simulations from Earth System Models (ESMs) available from the Coupled Model Intercomparison Project Phase 5. Results from this analysis are compared to the ERA‐Interim reanalysis. Moreover, we study the connection of the Etesians to the atmospheric circulation over EMED and the wider Indian monsoon area, in particular over the west Indian summer monsoon (wISM) and the Bay of Bengal (BoB). Our findings suggest that while the ESMs underestimate the wind speed of the Etesians, their frequency and summer cycle are in good agreement to reanalysis. ESMs can accurately represent the summer atmospheric circulation and depict the connection between EMED and Indian summer monsoon (ISM), capturing the link between them. Finally, we highlight here the capability and efficiency of ESMs in representing the climatology of Etesians and related atmospheric circulation.