bluuebunny/crossref_metadata_2025_split huggingface dataset:
One‐Step Quantitative Single Nucleotide Polymorphism (SNP) Diagnosis By Modified Loop‐Mediated Isothermal Amplification (mLAMP)
Authors: Ren Yiqian , Li Yanru , Duan Xinrui , Wang Honghong , Wang Hui , Li Zhengping 
Published: January 2019

AbstractSingle nucleotide polymorphism (SNP) detection usually needs two steps: amplification (mostly by polymerase chain reaction) and genotyping of SNP by using the amplification products. To shorten the time and simplify the detection, it is ideal to develop a one‐step method, in which the amplification itself can be the SNP detection signal. Meanwhile the difficulty in developing one‐step technology is the suppression of the background amplification. In this work, we designed an artificial mismatch into the third position from the 3’ terminus of the probes to prevent false positive extension reaction of the probes, which greatly improved the selectivity of mutation detection. We integrated this high selective version of primer extension reaction with a rapid and isothermal nucleic acid amplification loop‐mediated isothermal amplification (LAMP) method to distinguish between wild‐type and mutant DNA. SYBR®Green I is selected as the fluorescent dye that is tested for real‐time measurement of the LAMP reaction by its fluorescence intensity.100aM single strand DNA (ssDNA) or double strand DNA (dsDNA) targets can be accurately determined and as low as 0.1% mutant DNA can be detected in the presence of a large excess of wild‐type DNA, indicating the high sensitivity and specificity. The real‐time measuring does not require the detection step after LAMP and gives a wide dynamic range for detection of DNA targets (from 100aM to 1 pM).
Single‐nucleotide polymorphism‐based chromosomal microarray analysis provides clues and insights into disease mechanisms
Authors: Daum H. , Meiner V. , Hacohen N. , Zvi N. , Eilat A. , Drai‐Hasid R. , Yagel S. , Zenvirt S. , Frumkin A. 
Published: January 2019

ABSTRACTObjectiveChromosomal microarray analysis (CMA) is the modality of choice for prenatal diagnosis in pregnancy with fetal malformation, as it has a high diagnostic yield for microdeletion/duplication syndromes. The aim of this study was to demonstrate the additional utility of single‐nucleotide polymorphism (SNP)‐based CMA in diagnosing monogenic diseases, imprinting disorders and uniparental disomy (UPD).MethodsCMA was performed using Affymetrix CytoScan array, for all indications in 6995 pregnancies, at a tertiary referral hospital from November 2013 to June 2018. We describe four cases that had a CMA result that provided a more comprehensive understanding of the complex genetic mechanisms underlying the clinical presentation.ResultsIn the first fetus, CMA was performed due to intrauterine growth restriction and revealed a 75 kbp maternally inherited microdeletion encompassing the Bloom syndrome gene (BLM). A diagnosis of Bloom syndrome was made upon identifying a paternally inherited common Ashkenazi founder mutation. In the second case, CMA was performed due to severely abnormal maternal serum analytes and revealed a deletion in 14q32.2q32.31 on the maternally inherited copy, leading to a diagnosis of Kagami–Ogata syndrome, which is an imprinting disorder. In the third case, amniocentesis was performed because of late‐onset fetal macrosomia and mild polyhydramnios. CMA detected a deletion encompassing the locus of Prader–Willi/Angelman syndrome. In the fourth case, amniocentesis was performed due to maternal cytomegalovirus seroconversion. Maternal UPD of the entire long arm of chromosome 11 was detected.ConclusionPrenatal CMA, based on oligo and SNP platforms, increases the diagnostic yield and enables a wider spectrum of disorders to be detected through the identification of complex genetic etiologies beyond only copy number variants. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
Null infinity and unitary representation of the Poincare group
Authors: Banerjee Shamik 
Published: January 2019

Abstract

Following Pasterski-Shao-Strominger we construct a new basis of states in the single-particle Hilbert space of massless particles as a linear combination of standard Wigner states. Under Lorentz transformation the new basis states transform in the Unitary Principal Continuous Series representation. These states are obtained if we consider the little group of a null momentum direction rather than a null momentum. The definition of the states in terms of the Wigner states makes it easier to study the action of space-time translation in this basis. We show by taking into account the effect of space-time translation that the dynamics of massless particles described by these states takes place completely on the null-infinity of the Minkowski space. We then second quantize the theory in this basis and obtain a manifestly Poincare invariant (field) theory of free massless particles living on null-infinity. This theory has unitary time evolution. The null-infinity arises in this case purely group-theoretically without any reference to bulk space-time. Action of BMS is particularly natural in this picture.
As a by-product we generalize the conformal primary wave-functions for massless particles in a way which makes the action of space-time translation simple. Using these wave-functions we write down a modified Mellin(-Fourier) transformation of the S-matrix elements. The resulting amplitude is Poincare covariant. Under Poincare transformation it transforms like products of primaries of inhomogeneous SL(2, ℂ) (ISL(2, ℂ)) inserted at various points of null-infinity. ISL(2, ℂ) primaries are defined in the paper.
Investigating experienced supervisor incivility: Does presenteeism play a role?
Authors: Oyet Mercy C. 
Published: January 2019

AbstractThis study investigated the role employees may play in making themselves targets of supervisor incivility. Drawing from Victim Precipitation Theory, and Conservation of Resources Theory, I hypothesized that engaging in presenteeism will be positively associated with experienced supervisor incivility, and that presentees’ experienced productivity loss will mediate this relationship. Furthermore, I hypothesized that presentees’ self-efficacy and perceived control (personal and condition resources, respectively) will each operate as boundary conditions of the presenteeism–productivity loss relationship such that presentees high in each resource will be less likely to experience supervisor incivility. I found that experienced productivity loss mediates the positive relationship between presenteeism and experienced supervisor incivility. Additionally, self-efficacy was found to moderate the presenteeism–productivity loss relationship; however, the relationship was stronger for low self-efficacy presentees, which increased the likelihood of experiencing supervisor incivility. Perceived control did not moderate the presenteeism–productivity loss relationship. I discuss the study’s implications for theory and practice.
Using network analysis to study globalization, regionalization, and multi-polarity—Introduction to special section
Authors: DE LOMBAERDE PHILIPPE , IAPADRE LELIO , MCCRANIE ANN , TAJOLI LUCIA 
Published: January 2019

AbstractIn this introduction to the special section on globalization, regionalization, and multi-polarity, we review network analysis applications to the study of globalization as a complex and multi-dimensional phenomenon and we explore the frontiers of our knowledge about the network properties of global systems. We focus on the global economic (trade and investment), political, and migration systems.
Linearized stability implies dynamic stability for equilibria of 1-dimensional, p-Laplacian boundary value problems
Authors: Rynne Bryan P. 
Published: January 2019

AbstractWe consider the parabolic, initial-boundary value problem
1$$\matrix{ {\displaystyle{{\partial v} \over {\partial t}} = \Delta _p(v) + f(x,v),} & {{\rm in}({\rm - 1},{\rm 1}) \times ({\rm 0},\infty ),} \cr {v( \pm 1,t) = 0,} \hfill \hfill \hfill & {{\rm t}\in [{\rm 0},\infty ),} \hfill \hfill \cr {v = v_0\in C_0^0 ([-1,1]),} & {{\rm in}[{\rm - 1},{\rm 1}] \times \{ {\rm 0}\} ,} \cr } $$
where Δp denotes the p-Laplacian on ( − 1, 1), with p > 1, and the function f:[ − 1, 1] × ℝ → ℝ is continuous, and the partial derivative fv exists and is continuous and bounded on [ − 1, 1] × ℝ. It will be shown that (under certain additional hypotheses) the ‘principle of linearized stability’ holds for equilibrium solutions u0 of (1). That is, the asymptotic stability, or instability, of u0 is determined by the sign of the principal eigenvalue of a suitable linearization of the problem (1) at u0. It is well-known that this principle holds for the semilinear case p = 2 (Δ2 is the linear Laplacian), but has not been shown to hold when p ≠ 2.We also consider a bifurcation type problem similar to (1), having a line of trivial solutions. We characterize the stability or instability of the trivial solutions, and the bifurcating, non-trivial solutions, and show that there is an ‘exchange of stability’ at the bifurcation point, analogous to the well-known result when p = 2.
Coercion and third-party mediation of identity-based conflict
Authors: Eriksson Jacob 
Published: January 2019

AbstractThis article analyses third-party mediation of identity-based conflicts, which are notoriously difficult to resolve. It seeks to reconcile the contradiction in the mediation literature between the need for less coercive strategies to ensure ownership of a peace agreement and the need for more coercive strategies to reach a final agreement. Through an analysis of mediation of the Israeli-Palestinian conflict, the article makes four contributions to existing literature. First, the article develops a theoretical ‘best fit’ model that proposes a u-shaped relationship between intensity of mediator coercion and transition through phases of negotiation. Second, it challenges the prevailing notion that pre-negotiation does not involve coercion. Third, it suggests that epistemological and ontological understandings of a conflict and the role of a mediator by both the mediator and the parties mean that mediators enjoy limited capacity to effectively shift from high- to low-coercive strategies. Multi-party mediation can provide the flexibility needed to execute the coercion u-curve effectively. Fourth, it challenges existing understandings of the US-mediated negotiations during the Annapolis process, 2007–08.
A Tutorial Survey and Comparison of Impedance Control on Robotic Manipulation
Authors: Song Peng , Yu Yueqing , Zhang Xuping 
Published: January 2019

SummaryThere have been significant interests and efforts in the field of impedance control on robotic manipulation over last decades. Impedance control aims to achieve the desired mechanical interaction between the robotic equipment and its environment. This paper gives the overview and comparison of basic concepts and principles, implementation strategies, crucial techniques, and practical applications concerning the impedance control of robotic manipulation. This work attempts to serve as a tutorial to people outside the field and to promote discussion of a unified vision of impedance control within the field of robotic manipulation. The goal is to help readers quickly get into the problems of their interests related to impedance control of robotic manipulation and to provide guidance and insights in finding appropriate strategies and solutions.
Gravitational wave optical counterpart searching based on GRAWITA and DLT40 project during LIGO O2 run
Authors: Yang Sheng 
Published: January 2019

AbstractThe identification of the electromagnetic(EM) counterpart of gravitational wave(GW) trigger in the sky localization is a very difficult task because of the large uncertainty. Two complementary approaches are used in order to search for EM counterpart of GW signal with a typical large sky localization uncertainty: wide-field tilling search on high probability GW region, e.g. Gravitational Wave Inaf Team(GRAWITA) project or pointed search of selected galaxies in high probability GW region, e.g. Distance Less Than 40 Mpc survey(DLT40) project.
Background Rejection using Convolutional Neural Networks
Authors: Zadrożny Adam , Goźlińska Beata 
Published: January 2019

AbstractThe paper presents a proof of concept method of background rejection based on convolutional neural networks (CNN). The method was tested on simulated data and achieved very high accuracy (100%). What is more, method based on CNN is very fast and could be easily applied to wide field surveys. Since early stage results suggest method is very accurate and robust, it could be helpful in creating very low-latency pipelines for EM Follow-up purposes, which will be needed in LIGO-Virgo O3 EM Follow-up.
AGILE Observations of GW Events
Authors: Verrecchia Francesco , Tavani Marco , Donnarumma Immacolata 
Published: January 2019

AbstractAGILE is a space mission of the Italian Space Agency dedicated to γ-ray astrophysics, launched in 2007. AGILE performed dedicated real-time searches for possible γ-ray counterparts of gravitational wave (GW) events detected by the LIGO-Virgo scientific Collaboration (LVC) during the O2 observation run. We present a review of AGILE observations of GW events, starting with the first, GW150914, which was a test case for future searches. We focus here on the main characteristics of the observations of the most important GW events detected in 2017, i.e. GW170104 and GW170817. In particular, for the former event we published γ-ray upper limits (ULs) in the 50 MeV – 10 GeV energy band together with a detailed analysis of a candidate precursor event in the Mini-Calorimeter data. As for GW170817, we published a set of constraining γ-ray ULs obtained for integrations preceding and following the event time. These results allow us to establish important constraints on the γ-ray emission from a possible magnetar-like remnant in the first ~1000 s following T0. AGILE is a major player in the search of electromagnetic counterparts of GW events, and its enhanced detection capabilities in hard X-ray/MeV/GeV ranges will play a crucial role in the future O3 observing run.
The Key Role of Atlantic Multidecadal Oscillation in Minimum Temperature Over North America During Global Warming Slowdown
Authors: Gan Zewen , Guan Xiaodan , Kong Xiangning , Guo Ruixia , Huang Haiyan , Huang Wei , Xu Yanjun 
Published: January 2019

AbstractDaily minimum temperature (Tmin) is an important variable in both global and regional climate changes, and its variability can greatly affect the ecological system. In the early 21st century, warming slowdown is seen over the North Hemisphere and North America is one of the major cooling centers. In this study, we found that Tmin experienced an obvious decline in North America during warming slowdown period. Such Tmin decline is closely related to the Atlantic Multidecadal Oscillation (AMO); the correlation between the decadal components of Tmin and AMO reached 0.71 during 1950–2014. According to composite analysis, the AMO on the positive (negative) phase takes two low‐pressure (high‐pressure) systems in the northeastern Pacific and the North Atlantic at night, accompanied by cyclonic (anticyclonic) circulations and warm (cold) advection in North America. Therefore, the analyses conclude that the Tmin decline during warming slowdown period is a result of the synchronous decrease of the AMO. The results emphasize the key role of AMO on the decadal variation of Tmin in North America.
First Evidence of Anoxia and Nitrogen Loss in the Southern Canary Upwelling System
Authors: Machu E. , Capet X. , Estrade P. A. , Ndoye S. , Brajard J. , Baurand F. , Auger P.‐A. , Lazar A. , Brehmer P. 
Published: January 2019

AbstractThe northeastern Atlantic hosts the most ventilated subsurface waters of any eastern boundary upwelling system, while coastal upwelling source waters are slightly above hypoxic levels. Anoxic conditions have previously been found offshore inside mesoscale eddies whose core waters undergo oxygen consumption for many months. Based on circumstantial in situ observations, this study demonstrates that the Senegalese coastal ocean is subjected to episodic occurrence of zero dissolved oxygen concentration at depth along with elevated nitrite concentration (11 mmol/m3) and nitrate/nitrite deficit to phosphate, thereby indicating severe anoxia and intense nitrogen loss. The anoxic event was associated with a prolonged upwelling relaxation episode in March 2012 and a nearshore diatom bloom that underwent degradation while being advected offshore in stratified waters. This is consistent with scenarios observed in other upwelling systems (Benguela and California), and such conditions are presumably frequent in the southern part of the Canary system.
Numerical Analysis of Dissociation Behavior at Critical Gas Hydrate Saturation Using Depressurization Method
Authors: Gil Seong‐Min , Shin Hyo‐Jin , Lim Jong‐Se , Lee Jaehyoung 
Published: January 2019

AbstractThe Korea Institute of Geoscience and Mineral Resources conducted depressurization experiments at various gas hydrate saturation conditions, using mini pressure cells, to determine critical gas hydrate saturation. Their results indicated that it is necessary to carry out a numerical simulation in connection with the experiments to determine the critical gas hydrate saturation at numerous conditions that could not be incorporated into the experiments. In this study, a numerical simulation model, which simulated a mini pressure cell, was developed to verify the results of the aforementioned experiments. The changes in the fluid density and computer tomography values showed a similar trend. The validated numerical simulation model was used to determine the dissociation behaviors and productivities for various gas hydrate saturation levels (10–80%). As the gas hydrate saturation increased, the fluid permeability decreased. The gas hydrate dissociation was slowed by this correlation, and the production of gas and water was delayed at 50–60% gas hydrate saturation. Thus, the critical gas hydrate saturation was determined to be 50–60% for the experimental conditions of the field production test at the Ulleung Basin, East Sea, Korea. A pressure difference was noticed between the production and injection points due to the pressure propagation being delayed at critical gas hydrate saturation. Verifying the results of the experiments proved useful to understanding the dissociation and multiphase flow patterns in various depressurization scenarios.
Simulating the Occurrence of the Last Sapropel Event (S1): Mediterranean Basin Ocean Dynamics Simulations Using Nd Isotopic Composition Modeling
Authors: Vadsaria T. , Ramstein G. , Dutay J.‐C. , Li L. , Ayache M. , Richon C. 
Published: January 2019

AbstractSapropels are sediments rich in black, pelagic organic matter which occur mainly in the Eastern Mediterranean, documenting anoxic environments and high biological productivity. The quasiperiodicity of deposition of sapropels ‐over millions of years‐ relates to the Earth's precession cycle, which directly enhances the African monsoon, ultimately increasing freshwater input from the Nile. The last sapropel event, S1, occurred about 10,000 years ago (Early Holocene), when the Mediterranean region was warmer and wetter than today. Several modeling studies reflect the impact of this climate and a stronger Nile influx on Mediterranean oceanic circulation, but the regional models used lacked the spatial resolution necessary to simulate winter intermediate and deep convection. Here, we investigate recently occurring changes in the convective areas in the Eastern Mediterranean, using a regional ocean–atmosphere coupled climate model of high spatial resolution, essential to the simulation of a realistic Mediterranean circulation for present‐day conditions. We focused on the thermohaline circulation and the simulation of neodymium isotopic composition to compare our modeling results to modern data and paleo‐proxies. A sensitivity experiment shows a radical response of the Mediterranean to enhanced Nile discharge, creating the appropriate conditions for sapropel formation. We thus demonstrate that increased discharge of the Nile River can trigger the shutdown of Eastern Mediterranean convection and create conditions favorable to the development of anoxic events.
DNA methylation in the human frontal cortex reveals a putative mechanism for age-by-disease interactions
Authors: McKinney Brandon C. , Lin Chien-Wei , Rahman Tanbin , Oh Hyunjung , Lewis David A. , Tseng George , Sibille Etienne 
Published: January 2019

AbstractA consistent gene set undergoes age-associated expression changes in the human cerebral cortex, and our Age-by-Disease Model posits that these changes contribute to psychiatric diseases by “pushing” the expression of disease-associated genes in disease-promoting directions. DNA methylation (DNAm) is an attractive candidate mechanism for age-associated gene expression changes. We used the Illumina HumanMethylation450 array to characterize genome-wide DNAm in the postmortem orbital frontal cortex from 20 younger (<42 years) and 19 older (>60 years) subjects. DNAm data were integrated with existing normal brain aging expression data and sets of psychiatric disease risk genes to test the hypothesis that age-associated DNAm changes contribute to age-associated gene expression changes and, by extension, susceptibility to psychiatric diseases. We found that age-associated differentially methylated regions (aDMRs) are common, robust, bidirectional, concentrated in CpG island shelves and sea, depleted in CpG islands, and enriched among genes undergoing age-associated expression changes (OR = 2.30, p = 1.69 × 10−27). We found the aDMRs are enriched among genetic association-based risk genes for schizophrenia, Alzheimer’s disease (AD), and major depressive disorder (MDD) (OR = 2.51, p = 0.00015; OR = 2.38, p = 0.036; and OR = 3.08, p = 0.018, respectively) as well as expression-based MDD-associated genes (OR = 1.48, p = 0.00012). Similar patterns of enrichment were found for aDMRs that correlate with local gene expression. These results were replicated in a large publically-available dataset, and confirmed by meta-analysis of the two datasets. Our findings suggest DNAm is a molecular mechanism for age-associated gene expression changes and support a role for DNAm in age-by-disease interactions through preferential targeting of disease-associated genes.