bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Characterization of Virgin Almond and Hazelnut Oils and Their By‐Products
Authors: Ojeda‐Amador Rosa M. , Fregapane Giuseppe , Salvador María Desamparados 
Published: September 2019

AbstractVarious cultivars of almonds (“Ferragnes,” “Guara,” “Largueta,” and “Marcona”) and hazelnuts (“Negret,” “Pauetet,” and “Tonda”), particularly their virgin oils and by‐products, are evaluated in this study. The almond and hazelnut virgin oils present high contents of oleic acid (59–73% and 76–80%, respectively) and α‐tocopherol (420–542 and 310–378 mg kg–1, respectively), as compared with other virgin vegetable oils. Aldehydes are the major contributors to their aromatic profile (54–74% almond oil and 30–40% hazelnut oil of total content), especially, benzaldehyde in almond oils (1.35–7.52 mg kg–1), and hexanal in hazelnut oils (0.99–1.27 mg kg–1). Statistical differences exist between the virgin almond and hazelnut oils and their varieties, for most of the chemical compounds studied. While all the nut varieties are high in polar phenolic compounds, “Ferragnes” almonds (1262 mg kg–1) and “Negret” hazelnuts (1720 mg kg–1) stand out. Accordingly, high antioxidant activity is also observed. Finally, the residual cakes may be considered a good source of polar phenolic compounds (823–2064 mg kg–1 almond cakes, 2261–4179 mg kg–1 hazelnut cakes), possessing high antioxidant capacity with potential applications of these by‐products as functional ingredients in food and non‐food formulations.Practical Applications: Virgin nut oils are gaining consumers’ preference due to their unique organoleptic attributes and potential health effects. It is therefore very relevant to establish their specific chemical composition, directly related to their properties, and that are greatly affected by the cultivar.
An improved user authentication protocol for wireless sensor networks
Authors: Kaur Damandeep , Kumar Devender , Saini Khushil Kumar , Grover Harmanpreet Singh 
Published: September 2019

AbstractWireless sensor networks (WSNs) have its applications in many domains such as agriculture, medicine, safety, and industry. Due to its wireless channel, it is vulnerable to many security threats. To provide end‐to‐end secure communication, various authentication and key agreement protocols have been discussed. Recently, Li et al have designed a mutual authentication and key agreement protocol for WSNs. However, it is found that this scheme does not resist to offline password guessing, device stolen, insider, and replay attacks besides user traceability problem. In this paper, a mutual authentication and key agreement protocol by overcoming the deficiencies of their scheme is proposed. Its formal security verification is shown using ProVerif tool. Its performance analysis is presented in terms of communication cost, computational cost, storage cost, and security features along with the other related schemes. It offers more security features than the other related schemes.
Effect of superfine grinding on the physicochemical properties of bulbs of Fritillaria unibracteata Hsiao et K.C. Hsia powder
Authors: Li Cai‐xia , Liu Ying‐ying , Feng Hai‐sheng , Ma Shi‐zhen 
Published: September 2019

AbstractThis work aimed to determine the influence of superfine grinding on the physicochemical properties of bulbs of Fritillaria unibracteata Hsiao et K.C. Hsia (BFU) powder. For this purpose, fine powder (FP) and two superfine powders (SPs) were obtained via superfine and conventional grinding methods. The properties of different powders were studied and compared. Compared with FP, SPs exhibited higher values in terms of the angle of repose, swelling capacity, ethanol extraction yield, total alkaloid content, and imperialine content, while lower values in terms of particle size and bulk density. Especially, the total alkaloid content of SP‐I increased by 66.7%. Proper grinding is more conducive to reduce particle size and improve alkaloid content. FTIR analysis indicates that no new functional groups produced after superfine grinding. XRD analysis suggests that grinding treatment lead to decreases in the crystallinity. Therefore, superfine grinding displays immense potential in the BFU application.
Numerical analysis of CO2 hydrate growth in a depleted natural gas hydrate formation with free water
Authors: Ahmad Sheraz , Li Yiming , Li Xiangfang , Xia Wei , Chen Zeen , Ullah Naeem 
Published: September 2019

AbstractA dynamically coupled mass, momentum, and heat transfer model was developed, which demonstrated the unstable behavior of CO2 movement inside porous sediment during high pressure injection and its transformation into solid hydrates. The presented mathematical model was solved using the implicit finite difference method, and through ordering the set of model equations, a complex integrated methodology could be established to analyze the CO2 hydrate nucleation procedure within P‐T equilibrium conditions. The results showed that the intrinsic permeability factor of the porous sediment had great influence on the pressure distribution. At 10−13 m2 intrinsic permeability, the formation pressure distribution became stable at an early stage of the hydrate growth process and remained stable afterwards. The overall hydrate covered length was 320 m due to the massive hydrate growth rate. When intrinsic permeability was reduced to 10−14 m2, it showed delay in pressure distribution and the overall hydrate covered length shifts to up to 310 m due to the delay in pressure distribution. Whereas at a 10−15 m2 intrinsic permeability factor, there was significant delay in pressure distribution so the injection pressure was not fully distributed even after 30 days of the induction process, which squeezed the hydrate covered length to 130 m. This pressure distribution had direct correlation with other parameter variations during the hydrate growth process, such as temperature distribution, hydrate growth rate, CO2 velocity, CO2 density, CO2 and H2O saturation, CO2 permeability, and interface boundary movement speed. Hence, the pressure distribution inside hydrate‐bearing sediment is the most dominant factor to enhance CO2 storage capacity but it does not give satisfactory results in extended formations. © 2019 The Authors. Greenhouse Gases: Science and Technology published by Society of Chemical Industry and John Wiley & Sons, Ltd.
Functional connectivity reveals dissociable ventrolateral prefrontal mechanisms for the control of multilingual word retrieval
Authors: Branzi Francesca M. , Martin Clara D. , Carreiras Manuel , Paz‐Alonso Pedro M. 
Published: September 2019

AbstractThis functional magnetic resonance imaging study established that different portions of the ventrolateral prefrontal cortex (vlPFC) support reactive and proactive language control processes during multilingual word retrieval. The study also examined whether proactive language control consists in the suppression of the nontarget lexicon. Healthy multilingual volunteers participated in a task that required them to name pictures alternately in their dominant and less‐dominant languages. Two crucial variables were manipulated: the cue‐target interval (CTI) to either engage (long CTI) or prevent (short CTI) proactive control processes, and the cognate status of the to‐be‐named pictures (noncognates vs. cognates) to capture selective pre‐activation of the target language. The results of the functional connectivity analysis showed a clear segregation between functional networks related to mid‐vlPFC and anterior vlPFC during multilingual language production. Furthermore, the results revealed that multilinguals engage in proactive control to prepare the target language. This proactive modulation, enacted by anterior vlPFC, is achieved by boosting the activation of lexical representations in the target language. Finally, control processes supported by both mid‐vlPFC and the left inferior parietal lobe, were similarly engaged by reactive and proactive control, possibly exerted on phonological representations to reduce cross‐language interference.
Layer‐by‐layer films based on catechol‐modified polysaccharides produced by dip‐ and spin‐coating onto different substrates
Authors: Almeida Ana C. , Vale Ana C. , Pires Ricardo A. , Reis Rui L. , Alves Natália M. 
Published: September 2019

AbstractLayer‐by‐layer films based on chitosan and hyaluronic acid were produced by dip‐ and spin‐coating techniques onto glass, 316L stainless steel and titanium. These natural polymers were modified with catechol groups, in order to build coatings with improved adhesive properties. Polymeric coatings were exclusively composed by both modified polymers whereas the multifunctional coatings combined an inorganic phase of bioactive glass nanoparticles with the polymeric layers to confer bioactivity. Ultraviolet–visible spectroscopy demonstrated that both polymers were successfully synthesized. Fourier transform infrared imaging was used as an innovative way to analyze the layer interdiffusion in these coatings. Their morphology was analyzed by scanning electron microscopy and atomic force microscopy, and their wettability was evaluated by water contact angle measurements. Major differences were found in the structure and surface properties of the coatings assembled either by dip‐ or spin‐coating. The spin‐coated films onto glass were smoother, with a more homogeneous structure and lower interdiffusion of polyelectrolytes layers, when compared with the dip‐coated ones. Furthermore, it was concluded that the intrinsic surface roughness of stainless steel and titanium substrates had great influence on the surface morphology and wettability of the coatings obtained from both layer‐by‐layer methodologies.
Doxorubicin‐induced senescence through NF‐κB affected by the age of mouse mesenchymal stem cells
Authors: Bashiri Dezfouli Ali , Salar‐Amoli Jamileh , Pourfathollah Ali Akbar , Yazdi Mina , Nikougoftar‐Zarif Mahin , Khosravi Mohammad , Hassan Jalal 
Published: September 2019

AbstractThe senescence is proposed as a defense mechanism against many anticancer drugs. This complication is marked by differences in cell appearance and inner structures underlying the impairment in function. In this experiment, doxorubicin‐induced senescence was assessed in mesenchymal stem cells (MSCs) isolated from the bone marrow of different‐aged Balb/c mice (1, 8, and 16 months old). In addition, doxorubicin kinetics in culture medium were investigated to compare the drug absorption rate by different‐aged MSCs. Several methods were exerted including Sandwich ELISA for NF‐κB activation, propidium iodide staining for cell cycle analysis, Flow‐fluorescent in‐situ hybridization (Flow‐FISH) assay for telomere length measurement, and specific staining for evaluation of β‐galactosidase. Determination of doxorubicin in a medium was performed by high‐performance liquid chromatography technique. Following doxorubicin exposure, cells underwent substantial telomere shortening, cell cycle arresting in G2 phase, and increased β‐galactosidase activity. Interestingly, the enhanced level of NF‐κB was observed in all age groups. The highest and lowest sensitivity to telomere shortening attributed to 1‐ and 8‐month‐old MSCs, respectively. In consistent with Flow‐FISH results, the β‐galactosidase activity was higher in young‐aged MSCs after treatment. Statistical analysis indicated a correlation between the reduction of telomere length and cessation in G2 phase. Regarding the obtained kinetics equations, the rate of doxorubicin absorption by all aged MSCs followed the same trend. In conclusion, the changing of some elements involved in doxorubicin‐induced senescence can be affected by the age of the cells significantly in young MSCs than two other age groups. Hereupon, these changing patterns can open new insights to develop anticancer therapeutic strategies.
Phantom validation of quantitative susceptibility and dynamic contrast‐enhanced permeability MR sequences across instruments and sites
Authors: Hobson Nicholas , Polster Sean P. , Cao Ying , Flemming Kelly , Shu Yunhong , Huston John , Gerrard Chandra Y. , Selwyn Reed , Mabray Marc , Zafar Atif , Girard Romuald , Carrión‐Penagos Julián , Chen Yu Fen , Parrish Todd , Zhou Xiaohong Joe , Koenig James I. , Shenkar Robert , Stadnik Agnieszka , Koskimäki Janne , Dimov Alexey , Turley Dallas , Carroll Timothy , Awad Issam A. 
Published: September 2019

BackgroundQuantitative susceptibility mapping (QSM) and dynamic contrast‐enhanced quantitative permeability (DCEQP) on magnetic resonance (MR) have been shown to correlate with neurovascular disease progression as markers of vascular leakage and hemosiderin deposition. Applying these techniques as monitoring biomarkers in clinical trials will be necessary; however, their validation across multiple MR platforms and institutions has not been rigorously verified.PurposeTo validate quantitative measurement of MR biomarkers on multiple instruments at different institutions.Study TypePhantom validation between platforms and institutions.Phantom ModelT1/susceptibility phantom, two‐compartment dynamic flow phantom.Field Strength/Sequence3T/QSM, T1 mapping, dynamic 2D SPGR.AssessmentPhilips Ingenia, Siemens Prisma, and Siemens Skyra at three different institutions were assessed. A QSM phantom with concentrations of gadolinium, corresponding to magnetic susceptibilities of 0, 0.1, 0.2, 0.4, and 0.8 ppm was assayed. DCEQP was assessed by measuring a MultiHance bolus as the consistency of the width ratio of the curves at the input and outputs over a range of flow ratios between outputs.Statistical TestsEach biomarker was assessed by measures of accuracy (Pearson correlation), precision (paired t‐test between repeated measurements), and reproducibility (analysis of covariance [ANCOVA] between instruments).ResultsQSM accuracy of r2 > 0.997 on all three platforms was measured. Precision (P = 0.66 Achieva, P = 0.76 Prisma, P = 0.69 Skyra) and reproducibility (P = 0.89) were good. T1 mapping of accuracy was r2 > 0.98. No significant difference between width ratio regression slopes at site 2 (P = 0.669) or site 3 (P = 0.305), and no significant difference between width ratio regression slopes between sites was detected by ANCOVA (P = 0.48).Data ConclusionThe phantom performed as expected and determined that MR measures of QSM and DCEQP are accurate and consistent across repeated measurements and between platforms.Level of Evidence: 1Technical Efficacy Stage: 2J. Magn. Reson. Imaging 2020;51:1192–1199.
Safety and Efficacy of MRI Scans in Patients With Implanted Microvascular Coupling Devices
Authors: Phalke Neelam , Thomas W. Walsh , Azzi James , Li Ryan J. , Petrisor Daniel , Wax Mark K. 
Published: September 2019

ObjectiveTo demonstrate the safety and compatibility of microvascular couplers in patients undergoing postoperative magnetic resonance imaging (MRI) scans.Study DesignRetrospective case series.MethodsA consecutive review of 1,252 patients undergoing free tissue transfer for head and neck reconstruction at Oregon Health and Sciences University (OHSU) between 2010 and 2017 who had microvascular coupler Synovis, Baxter Deerfield, IL (Synovis Life Technologies, Saint Paul, MN) implantation were reviewed. One hundred fifteen patients had a subsequent MRI scan, which consisted of a variety of Phillips (Amsterdam, Netherlands) MRI machines ranging from 1.0 to 3.0 Tesla (T) in magnetic strength.ResultsThese 115 patients underwent 121 free flaps with 131 couplers (including 32 flow couplers) utilized for venous anastomoses. Couplers ranged in size from 1.5 to 4.0 mm (3.0 mm [42%] followed by 3.5 mm [21%], 2.5 mm [19%], 2.0 mm [10%], 4.0 mm [6%], and 1.5 mm [2%]. Three hundred fifty‐nine MRI scans (2 days to 91 months postoperatively) were obtained with 233 MRIs for cancer surveillance, and the remaining were obtained for neurologic disease, injury, or evaluation for metastases. No complications occurred related to the MRI and the metallic components of the coupler or other metal implants, such as reconstruction bars, vascular clips, or metallic surgical mesh. Additionally, no radiology report commented on MRI distortion due to the coupler placement, which contrasts the distortion seen with the other metallic implants.ConclusionMicrovascular couplers and their constitutive stainless‐steel pins have not been found to cause any complications in a large series of consecutive patients undergoing multiple MRIs with magnetic strength up to 3 T. The U.S. Food and Drug Administration advocates medical alert notification for patients with couplers; however, hesitation regarding potential MRI scanning for surveillance or otherwise is unwarranted.Level of Evidence4 Laryngoscope, 130:1428–1430, 2020
Examining the Reserve Hypothesis in Parkinson's Disease: A Longitudinal Study
Authors: Lee Pei‐Chen , Artaud Fanny , Cormier‐Dequaire Florence , Rascol Olivier , Durif Franck , Derkinderen Pascal , Marques Ana‐Raquel , Bourdain Frédéric , Brandel Jean‐Philippe , Pico Fernando , Lacomblez Lucette , Bonnet Cecilia , Brefel‐Courbon Christine , Ory‐Magne Fabienne , Grabli David , Klebe Stephan , Mangone Graziella , You Hana , Mesnage Valérie , Brice Alexis , Vidailhet Marie , Corvol Jean‐Christophe , Elbaz Alexis ,   for the DIGPD Study Group
Published: September 2019

AbstractBackgroundWhether reserve plays a role in Parkinson's disease (PD) patients has received less attention than in dementia and has been mainly examined in relation with cognitive function.ObjectiveTo investigate whether reserve plays a role in the severity and progression of motor, cognitive, and nonmotor PD symptoms by examining whether education level (proxy of reserve) is associated with baseline performance and rate of progression.MethodsWe used data from a longitudinal cohort of PD patients (≤5‐year disease duration at baseline) annually followed up to 5 years (n = 393; 41% women; mean age = 62.3 years, standard deviation = 10.0; mean disease duration = 2.6 years, standard deviation = 1.5). We examined the relationship of education with time to reach Hoehn and Yahr stage ≥3 using Cox regression and with baseline severity and progression of motor (Movement Disorder Society–Unified Parkinson's Disease Rating Scale parts II and III, gait speed), cognitive (Mini‐Mental State Examination), and nonmotor (depression, anxiety, nonmotor symptoms scale, quality of life) symptoms using mixed models.ResultsEducation level was not associated with age at onset or diagnosis. Compared with the low‐education group, the incidence of Hoehn and Yahr ≥3.0 was 0.42 times lower (95% confidence interval, 0.22–0.82, P = 0.012) in the high‐education group. Higher education was associated with better baseline motor function (P < 0.001), but not with the rate of motor decline (P > 0.15). Similar results were observed for cognition. Education was not associated with nonmotor symptoms.ConclusionsHigher education is associated with better baseline motor/cognitive function in PD, but not with rate of decline, and with a lower risk of reaching Hoehn and Yahr ≥3 during the follow‐up. Our observations are consistent with a passive reserve hypothesis for motor/cognitive symptoms. © 2019 International Parkinson and Movement Disorder Society
Policy Challenges Relating to Integrated Pest Management of Freshwater Aquatic Invasive Animals
Authors: Hoff Michael H. , Irons Kevin S. , Forester Jeffery E. 
Published: September 2019

Abstract
Implementing integrated pest management (IPM) approaches to prevent invasion, contain and control established freshwater aquatic invasive animals (AIAs), and mitigate the impacts of those species has been limited, in part, because of policy-related challenges. Scientific tools are being developed and tested that are designed to enhance IPM effectiveness and efficiency for managing AIAs. However, policy challenges may limit the near-term use of IPM at the international and U.S. national, regional, state, and local levels. Policy challenges include unmet needs for authorities, governance, environmental compliance, funding, and decision support. Policy challenges can be addressed by improvements in legislative authorities, establishing needed governance, proactively meeting environmental compliance requirements, and funding IPM for species commensurate with benefits of programs in comparison with present and projected ecological, social, and economic impacts. Decision support tools are needed to evaluate which species, invasional stages, IPM program elements, and locations are priorities for allocating scarce resources and for justifying additional resources. Addressing those challenges could be either comprehensive and holistic (e.g., all freshwater aquatic animals in the USA) or species/taxon/geographically specific (e.g., Sea Lamprey Petromyzon marinus in the Great Lakes).
A case example of one state's efforts to measure and address the critical shortage of school psychologists
Authors: Mann Angela , Castillo Jose , Myers Mary Alice 
Published: September 2019

AbstractDespite persistent calls for school psychologists to provide comprehensive and integrated services, school psychologists may have difficulty providing these services because of critical shortages in the profession. This practical action research study involved surveying district supervisors of school psychologists and training program directors in the state to identify the current and projected shortages in Florida. This multimethod, multi‐informant case example also focused on facilitators of and barriers to addressing the critical shortage. How the data have been used to inform recruitment, retention, and advocacy efforts to identify school psychology as a critical shortage legislatively are provided as well as recommendations for future research.
The calcium‐sensing receptor: A novel target for treatment and prophylaxis of neratinib‐induced diarrhea
Authors: Lysyy Taras , Lalani Alshad S. , Olek Elizabeth A. , Diala Irmina , Geibel John P. 
Published: September 2019

AbstractDiarrhea is one of the most commonly reported adverse effect of hemotherapy and targeted cancer therapies, such as tyrosine kinase inhibitors (TKI), which often significantly impact patient quality of life, morbidity, and mortality. Neratinib is an oral, irreversible pan‐HER tyrosine kinase inhibitor, which is clinically active in HER2‐positive breast cancer. Diarrhea is the most common side effect of this potent anticancer drug and the reasons for this adverse effect are still largely unclear. We have recently shown that activation of the calcium‐sensing Receptor (CaSR) can inhibit secretagogue‐induced diarrhea in the colon, therefore we hypothesized that CaSR activation may also mitigate neratinib‐induced diarrhea. Using an established ex vivo model of isolated intestinal segments, we investigated neratinib‐induced fluid secretion and the ability of CaSR activation to abate the secretion. In our study, individual segments of the rat intestine (proximal, middle, distal small intestine, and colon) were procured and perfused intraluminally with various concentrations of neratinib (10, 50, 100 nmol L−1). In a second set of comparison experiments, intraluminal calcium concentration was modulated (from 1.0 to 5.0 or 7.0 mmol L−1), both pre‐ and during neratinib exposure. In a separate series of experiments R‐568, a known calcimimetic was used CaSR activation and effect was compared to elevated Ca2+ concentration (5.0 and 7.0 mmol L−1). As a result, CaSR activation with elevated Ca2+ concentration (5.0 and 7.0 mmol L−1) or R‐568 markedly reduced neratinib‐induced fluid secretion in a dose‐dependent manner. Pre‐exposure to elevated luminal calcium solutions (5.0 and 7.0 mmol L−1) also prevented neratinib‐induced fluid secretion. In conclusion, exposure to luminal neratinib resulted in a pronounced elevation in fluid secretion in the rat intestine. Increasing luminal calcium inhibits the neratinib‐associated fluid secretion in a dose‐dependent manner. These results suggest that CaSR activation may be a potent therapeutic target to reduce chemotherapy‐associated diarrhea.