bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel messenger RNA and long noncoding RNA signature associated with the progression of nonmuscle invasive bladder cancer
Authors: He Yu‐hui , Deng Yi‐sen , Peng Pan‐xin , Wang Ning , Wang Jian‐feng , Ding Zhen‐shan , Chen Xing , Zhou Xiao‐feng 
Published: November 2018

AbstractAimTo explore the molecular mechanism of nonmuscle invasive bladder cancer (NMIBC), matched normal, and cancer tissues of 10 NMIBC were examined for RNA sequencing.MethodsWe profiled the messenger RNA (mRNA) and long noncoding RNA (lncRNA) expression of patients with NMIBC. Differentially expressed mRNAs and lncRNAs were screened between cancer and normal tissues and validated by quantitative polymerase chain reaction (qPCR), and lncRNA‐mRNA‐miRNA interaction network was constructed.ResultsA total of 91 upregulated and 190 downregulated genes and 34 upregulated and 58 downregulated lncRNAs were screened from the sequencing result. The differentially expressed mRNAs were enriched in focal adhesion, rap1 signaling pathway, Hippo signaling pathway, PI3K‐Akt signaling pathway, extracellular matrix (ECM)‐receptor interaction, Ras signaling pathway, and mitogen‐activated protein kinases signaling pathway, of which some pathways were involved in the cancer development. In the RNA sequencing, KIT and laminin subunitγ γ3 (LAMC3) were significantly downregulated in the NMIBC group compared with the normal group. The results of quantitative reverse transcription PCR showed that the expression of LAMC3 and KIT were significantly decreased in the NMIBC group compared with the normal group. The lncRNA‐mRNA‐miRNA interaction network was constructed by Cytoscape software to further investigate the interaction correlations. The results implied that KIT and LAMC3 might regulate the lncRNAs (such as ENST00000445707, ENST00000501122, ENST00000505254, ENST00000528986, ENST00000557661, ENST00000602964, ENST00000614517, ENST00000620864, and ENST00000623414) by the miRNAs (such as hsa‐let‐7f‐2‐3p, hsa‐miR‐125a‐3p, hsa‐miR‐134‐3p, hsa‐miR‐191‐5p, hsa‐miR‐210‐5p, hsa‐miR‐30a‐5p, hsa‐miR‐30d‐5p, hsa‐miR‐30e‐5p, hsa‐miR‐92a‐2‐5p, and hsa‐miR‐95‐3p), and finally played a role in the development of NMIBC cancer.ConclusionAltogether, our study preliminarily indicated that KIT and LAMC3 might play a crucial role in the development of NMIBC cancer via a complex mRNA‐lncRNA‐miRNA regulatory network.
Population Pharmacokinetics of Adjunctive Lacosamide in Pediatric Patients With Epilepsy
Authors: Winkler Julia , Schoemaker Rik , Stockis Armel 
Published: November 2018

AbstractA pediatric population pharmacokinetic model including covariate effects was developed using data from 2 clinical trials in pediatric patients with epilepsy (SP0847 and SP1047). Lacosamide plasma concentration‐time data (n = 402) were available from 79 children with body weights ranging from 6 to 76 kg, and a balanced age distribution (6 months to <2 years: n = 14; 2 to <6 years: n = 22; 6 to <12 years: n = 25; 12 to <18 years: n = 18). A single‐compartment population pharmacokinetic model with first‐order absorption and elimination described the data adequately. Plasma clearance was modeled using allometric scaling on body weight with a freely estimated allometric exponent, while volume of distribution used a fixed theoretical allometric exponent. Covariate search identified a significant effect of enzyme‐inducing antiepileptic drugs resulting in a 35% decrease in lacosamide average plasma concentration. No additional effects on clearance could be attributed to race, sex, age, or renal function. Different dosing adaptation schemes by body weight bands were simulated to approximate, in pediatric patients aged 4 to 17 years, the same average plasma concentration as in adult patients receiving the maximum recommended lacosamide daily dose.
Retracted: Self‐floating Cu/N co‐doped TiO2/diatomite granule composite with enhanced visible‐light‐responsive photoactivity and reusability
Authors: Chen Yan , Wu Qiong , Song Youtao 
Published: November 2018

AbstractBACKGROUNDThe remnants of antibiotics in aquatic environments have emerged as hazardous pollutants. To eliminate these remnants, new methods have been proposed, including photocatalysis. Powdery photocatalysis has been widely studied, yet its several disadvantages such as light‐harvesting and recyclability in suspension systems have remained as bottlenecks for practical applications. A recent report on a floating photocatalyst provided an alternative method to solve the above problems. In the present paper, TiO2 nanoparticles were co‐doped by copper (Cu) and nitrogen (N), and then immobilized onto substrate diatomite. The composite powder was granulated to produce a self‐floating granule catalyst (Cu/N co‐doped TiO2/diatomite hybrid granules), denoted as CN‐TDHG. The photoactivity of CN‐TDHG was investigated via the degradation of antibiotic oxytetracycline (OTC) under visible light.RESULTSThe characterization results indicated that Cu/N co‐doped TiO2 nanoparticles were successfully dispersed onto the surface of diatomite. Compared to powdery composite, the granule catalyst presented enhanced photodegradation efficiency. Optimal values of both doping amount and granule dosage were determined. The optimal granule catalyst removed 92.5% OTC within 150 min reaction time. Based on the experimental results, the corresponding photodegradation mechanism was proposed.CONCLUSIONThe self‐floating granule catalyst presented enhanced photodegradation capability, thanks to the synergy between Cu‐ and N‐dopants, as well as the adsorption and degradation dual processes between TiO2 and diatomite. Moreover, CN‐TDHG could simply be filtered from the surface of the water matrix, and presented good stability and reusability after five repetitions, proving itself as a promising candidate for the remediation of water environment. © 2018 Society of Chemical Industry
Fractal graphs
Authors: Ille Pierre , Woodrow Robert 
Published: November 2018

AbstractThe lexicographic sum of graphs is defined as follows. Let be a graph. With each associate a graph . The lexicographic sum of the graphs over is obtained from by substituting each by . Given distinct , we have all the possible edges in the lexicographic sum between and if , and none otherwise. When all the graphs are isomorphic to some graph , the lexicographic sum of the graphs over is called the lexicographic product of by and is denoted by . We say that a graph is fractal if there exists a graph , with at least two vertices, such that . There is a simple way to construct fractal graphs. Let be a graph with at least two vertices. The graph is defined on the set of functions from to as follows. Given distinct is an edge of if is an edge of , where is the smallest integer such that . The graph is fractal because . We prove that a fractal graph is isomorphic to a lexicographic sum over an induced subgraph of , which is itself fractal.
Impact of the intra‐seasonal oscillation on tropical cyclone genesis over the western North Pacific
Authors: You Lijun , Gao Jianyun , Lin Hai , Chen Si 
Published: November 2018

This study investigates the impact of the East Asian–western North Pacific (EAWNP) intra‐seasonal oscillation (ISO) on tropical cyclone (TC) genesis over the South China Sea (SCS) and the western North Pacific (WNP). The result indicates that the 20–70‐day oscillation (EAWNP‐ISO1) mainly modulates the frequency of TC genesis, while the 10–20‐day quasi‐biweekly oscillation (EAWNP‐ISO2) usually influences the genesis location. The impacts of ISO are not only on the individual TC genesis but also on the intra‐seasonal variation of TC activity.In order to better monitor and predict TC genesis, we group the ISO intensity into three categories (wet, normal, and dry) using the EAWNP ISO‐1 index and classify the ISO location into three categories (south, middle, and north) using the EAWNP ISO‐2 index. By combining these six categories, nine combinations are defined to further investigate how the ISO impact on TC genesis. It was found that through affecting the strength of monsoon trough and the location of the western Pacific subtropical high, the ISO combinations modulate the thermodynamic conditions and lead to changes in frequency and location of TC genesis.The relative contributions of four variables of the genesis potential index (GPI) tend to be dependent on ISO conditions. When the ISO conditions are favourable (unfavourable) to TC genesis, the mid‐level humidity and low‐level vorticity contribute positively (negatively) to the GPI anomalies over the SCS and WNP region, while the vertical wind shear, except for in the north SCS, and the potential intensity contribute negatively (positively). During the normal ISO conditions, the contributions of these four variables are generally weaker than those under the other two backgrounds.
Effect of skimmed milk and vegetable powders on shelf stability of millet‐based composite flour
Authors: Tumwine Gerald , Atukwase Abel , Tumuhimbise Gaston A , Tucungwirwe Francis , Linnemann Anita 
Published: November 2018

AbstractBACKGROUNDMillet porridge is a major complementary food used in Uganda but it is limited in protein and micronutrients such as zinc and beta‐carotene. Addition of milk and vegetable powders are known to greatly improve the nutrient content of millet flour. However, there was limited information on the shelf stability of the resultant composite flour. This study aimed at assessing the effect of milk and vegetable powders on the shelf stability of millet‐based composite flour.RESULTSThere was a general increase in the moisture content, peroxide value (PV), free fatty acids (FFA), thiobaturic acid (TBA) and total plate count (TPC) of both composite and millet flours over the eight weeks storage period. However, higher moisture content, PV, FFA, TBA and TPC values were recorded in the composite flour compared to millet flour (control) at each sampling interval. Sensory evaluation results revealed that panelists preferred porridges prepared from millet only compared to those from composite flour. The degree of liking of porridges from both composite and millet flours generally decreased over the storage period. However, both porridges were deemed as acceptable by the end of the storage period. The TPC also remained below 105 cfu g−1 which is the maximum limit recommended by the Uganda National Bureau of Standards (UNBS).CONCLUSIONThe study findings indicated that the addition of milk and vegetable powders negatively affected the stability of the composite flour. We recommend further studies to stabilize the product during storage. © 2018 The Authors. Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Multioutputs single‐stage gate driver on array with wide temperature operable thin‐film‐transistor liquid‐crystal display for high resolution application
Authors: Liu Po‐Tsun , Zheng Guang‐Ting , Lin Yi‐Chen 
Published: November 2018

AbstractA hydrogenated amorphous silicon (a‐Si:H) thin‐film transistor (TFT) gate driver with multioutputs (eight outputs per stage) for high reliability, 10.7‐inch automotive display has been proposed. The driver circuit is composed of one SR controller, eight driving TFTs (one stage to eight outputs) with bridging TFTs. The SR controller, which starts up the driving TFTs, could also prevent the noise of gate line for nonworking period. The bridging TFT, using width decreasing which connects between the SR controller and the driving TFT, could produce the floating state which is beneficial to couple the gate voltage, improves the driving ability of output, and reaches consistent rising time in high temperature and low temperature environment. Moreover, 8‐phase clocks with 75% overlapping and dual‐side driving scheme are also used in the circuit design to ensure enough charging time and reduce the loading of each gate line. According to lifetime test results, the proposed gate driver of 720 stages pass the extreme temperature range test (90°C and −40°C) for simulation, and operates stably over 800 hours at 90°C for measurement. Besides, this design is successfully demonstrated in a 10.7‐inch full HD (1080 × RGB×1920) TFT‐liquid‐crystal display (LCD) panel.
Counter‐current chromatography melamine‐modified column and its separation mechanism
Authors: Quan Kai‐Jun , Huang Xin‐Yi , Gong Yuan , Pei Dong , Duan Wen‐Da , Di Duo‐Long 
Published: November 2018

AbstractIn this work, to further verify and develop the novel counter‐current chromatography modified column separate mode, a melamine modified counter‐current chromatography column was prepared. Meanwhile, the modified counter‐current chromatography column was used to separate stevioside and rebaudioside A with the same partition coefficient in chosen solvent system to evaluate its separation efficiency. The results show that because of the presence of intermolecular forces between melamine and model compounds, better separation could be achieved on the modified column while it's almost impossible to be separated on the unmodified column. So the results of this research further show that column modified method is a possible approach to further increase the separation ability of counter‐current chromatography. Take advantage of large sample handing capacity of counter‐current chromatography, the mothed may have great potential to be an efficient method of separation and preparation enantiomer compounds.
Study on the metabolites of betulinic acid in vivo and in vitro by ultra high performance liquid chromatography with time‐of‐flight mass spectrometry
Authors: Zhang Wen‐dan , Jin Miao‐miao , Jiang Hong‐hong , Yang Jian‐xi , Wang Qiao , Du Ying‐feng , Cao Liang , Xu Hui‐jun 
Published: November 2018

AbstractBetulinic acid is a triterpenoid organic acid with remarkable antitumor properties and is naturally present in many fruits, condiments and traditional Chinese medicines. Currently, a strategy was developed for the identification of metabolites following the in vivo and in vitro biotransformation of Betulinic acid with rat intestinal bacteria utilizing ultra high performance liquid chromatography with time‐of‐flight mass spectrometry with polymeric solid‐phase extraction. As a result, 46 metabolites were structurally characterized. The results demonstrated that Betulinic acid is universally metabolized in vivo and in vitro, and Betulinic acid could undergo general metabolic reactions, including oxidation, methylation, desaturation, loss of O and loss of CH2. Additionally, the main metabolic pathways in vivo and in vitro were determined by calculating the relative content of each metabolite. This is the first study of Betulinic acid metabolism in vivo, whose results provide novel and useful data for better understanding of the safety and efficacy of Betulinic acid.
Variable high‐pressure and concentration study of cyclohexane pyrolysis at high temperatures
Authors: Liszka Miroslaw Krzysztof , Brezinsky Kenneth 
Published: November 2018

AbstractA high‐pressure and temperature cyclohexane pyrolysis shock tube study was completed with the goal of extending the experimental cyclohexane pyrolysis data to pressures relevant to current and future combustors and to investigate whether ring contraction products observed in high‐pressure, supercritical phase cyclohexane and cycloalkane pyrolysis experiments can form at matching, and higher, pressures in the gas phase. The experiments in the current work were completed over a range of 950–1650 K and at nominal pressures of 40, 100, and 200 bar. No alkylcyclopentanes, possible ring contraction products, were observed to form under the conditions of the current study. The production of methylenecyclopentane and 1,3‐cyclopentadiene, and the other three cyclic species quantified: cyclohexene, benzene, and toluene, increased significantly with a substantial increase in the initial fuel concentration. Two sets of experimental data obtained at 200 bar were compared with a literature and laboratory‐generated model. Both models had difficulty capturing the propadiene and propyne profiles, and the literature model significantly overestimated the benzene observed in the set of experiments completed with the more dilute fuel mixture. The literature model was able to better predict propadiene, propyne, and benzene product profiles in the 200 bar set of experiments, which used a higher concentration of fuel in the test gas. These results suggest that despite both cyclohexane and benzene being well‐studied and important species in combustion chemistry, their reaction pathways and reaction rates would benefit from further refinement.
Disentangling limnological processes in the time‐frequency domain
Authors: Schmidt Silke R. , Lischeid Gunnar , Hintze Thomas , Adrian Rita 
Published: November 2018

AbstractState variables in lake ecosystems are subject to processes that act on different time scales. The relative importance of each of these processes changes over time, e.g., due to varying constraints of physical, biological, and biogeochemical processes. Correspondingly, continuous automatic measurements at high temporal resolution often reveal intriguing patterns that can rarely be directly ascribed to single processes. In light of the rather complex interplay of such processes, disentangling them requires more powerful methods than researchers have applied up to this point. For this reason, we tested the potential of wavelet coherence, based on the assumption that different processes result in correlations between different variables, on different time scales and during different time windows across the seasons. The approach was tested on a set of multivariate hourly data measured between the onset of an ice cover and a cyanobacterial summer bloom in the year 2009 in the Müggelsee, a polymictic eutrophic lake. We found that processes such as photosynthesis and respiration, the growth and decay of phytoplankton biomass, dynamics in the CO2‐carbonate system, wind‐induced resuspension of particles, and vertical mixing all occasionally served as dominant drivers of the variability in our data. We therefore conclude that high‐resolution data and a method capable of analyzing time series in both the time and the frequency domain can help to enhance our understanding of the time scales and processes responsible for the high variability in driver variables and response variables, which in turn can lay the ground for mechanistic analyses.
Consumer aliteracy
Authors: DelVecchio Devon S. , Jae Haeran , Ferguson Jodie L. 
Published: November 2018

AbstractA large and growing segment of global society is comprised of capable but unwilling readers. Despite the proliferation of aliteracy and extant research on illiterate consumers, the topic of consumer aliteracy is unexplored. To address the issue, an eight‐item unidimensional measure of the construct is developed and validated. This consumer aliteracy scale captures reading attitudes and behaviors across a variety of written marketing materials. Results indicate that consumer aliteracy is predictive of how consumers approach written versus visual marketing information and the amount of time devoted to these information formats in a choice setting. Understanding the phenomenon of consumer aliteracy is essential for researchers studying consumer responses to a wide variety of written marketing materials. In addition, consideration of consumer aliteracy may help research that employs written marketing messages as stimuli to better detect other processing effects.
Robust real‐time inversion of electrical impedance tomography data for human lung ventilation monitoring
Authors: Salucci Marco , Oliveri Giacomo 
Published: November 2018

AbstractThis work presents an innovative strategy for the real‐time monitoring of the human lungs from electrical impedance tomography (EIT) data. The inverse problem at hand is solved within the learning‐by‐examples (LBE) framework by formulating the estimation of the lungs conductivity as a regression problem. Toward this end, the partial least squares (PLS) feature extraction technique is integrated within an adaptive sampling scheme to generate optimal (ie, highly‐informative and low cardinality) training sets for training a support vector regressor (SVR). Accurate predictions are then performed in the on‐line testing phase with remarkable robustness to the noise.
Quasi blind carrier phase estimation scheme for special‐shaped circular (7,1) modulation in high‐speed visible light communication
Authors: Liang Shangyu , Zhao Jiaqi , Zhou Yingjun , Zhang Mengjie , Chi Nan 
Published: November 2018

AbstractA novel digital signal processing (DSP) scheme for special‐shaped circular (7,1) modulated signals based on quasi blind carrier phase estimation (QBCPE) is proposed. The results show that applying 0.33‰ overhead QBCPE provides similar performance as 3% training sequence data‐aided equalization of least mean square (LMS) algorithm.
Challenging Subjects: Towards Ethnographic Analyses of Animals
Authors: Coulter Kendra 
Published: November 2018

AbstractThis article is an exploration of and experiment in animal‐centric ethnographic research. I first delve into key conceptual, scholarly, and practical issues which extend from the growing interdisciplinary interest in human‐animal relations, and the anthropological emphasis on multispecies ethnography. I then offer experimental ethnographic data focused on horses in show jumping stables in Canada. I approach the horses as both biological and sociocultural beings who affect and are affected by their formal jobs as show jumping horses. Through the concept of work‐lives, I also highlight the multi‐dimensional nature of their experiences as whole beings who have their own relationships and interests which are simultaneously shaped by and distinct from their human‐prescribed roles. I am interested in the methodological possibilities as gateways to deeper understanding of animals, more ethical practice within and beyond universities, and more just multispecies futures.