bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 3290: Risk factors for post-radiotherapy pain in a multi-racial ethnic population of breast cancer patients: a prospective study
Authors: Lee Eunkyung , Snyder Shannon , Ip Edward , Wright Jean L. , Hu Jennifer J. 
Published: August 2019

Abstract
Cancer and/or treatment-related pain is a critical quality of life issue for cancer survivors. In a prospective longitudinal study of 1,000 breast cancer patients (enrolled during 2011-2013), we examined risk factors for pain among women undergoing adjuvant radiotherapy (RT). A pain score was assessed as a mean of four pain severity items (i.e., pain at its worst, least, average, and now) from the Brief Pain Inventory with an 11-point numeric rating scale (0-10) at baseline and post-RT. The study sample consists of 623 whites, 280 black/African Americans, 64 Hispanic whites, and 33 others. The mean age was 58.1 ±10.8 years and the mean body mass index (BMI) was 30.7 ±7.0 kg/m2. The mean pain score was 1.5 ±1.0 (baseline) and 2.5 ±1.8 (post-RT). In multivariable linear regression analysis (n= 863), post-RT pain score was significantly associated with baseline pain score (β= 0.39 per 1 point increment, p&lt; 0.0001), age (β= -0.03 per 1 year increment, p&lt; 0.001), BMI (β= 0.03 per 1 kg/m2 increment, p= 0.004), current smoking status (β= 0.57, p= 0.022), conventional RT fractionation (β= 0.48, p= 0.033), and pain medication use (β= 1.85, p&lt; 0.0001). Further stratified analysis showed that post-RT pain score was associated with baseline pain score, age, BMI, and mastectomy among patients who did not use pain medication (n= 625); however, it was associated with baseline pain score and conventional RT fractionation among patients who did use pain medication (n= 238). Altogether, baseline pain score is the most significant and robust risk factor for post-RT pain, and conventional RT fractionation is a significant risk factor post-RT pain only among those who experienced more pain. These risk factors may help identify individuals at-risk for post-RT pain; thus, this information may help guide these high-risk individuals in their RT decision-making processes, such as considering a hypo-fractionated RT schedule.
Citation Format: Eunkyung Lee, Shannon Snyder, Edward Ip, Jean L. Wright, Jennifer J. Hu. Risk factors for post-radiotherapy pain in a multi-racial ethnic population of breast cancer patients: a prospective study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3290.
Abstract 3299: Socio-demographic and lifestyle factors associated with the neutrophil-to-lymphocyte ratio: A systematic evaluation of the United States National Health and Nutrition Examination Survey
Authors: Howard Rachel , Scheiner Aaron , Egan Kathleen M. 
Published: August 2019

Abstract
Background:
The neutrophil-to-lymphocyte ratio (NLR) is an established marker of subclinical inflammation, and a high NLR is associated with poorer clinical outcomes in cancer patients. Despite this, factors that influence the magnitude of NLR independently of disease are poorly understood. Here, we systematically assess the influence of socio-demographic and lifestyle factors on NLR to identify a) potential confounders and effect modifiers in the relationship between NLR and cancer outcomes, and b) possible targets for intervention in patients with high NLR at diagnosis.
Methods:
Based on a total participant cohort of 48,023 adults with available NLR data, we identified 20 factors of interest relating to patient demographics, socioeconomic status and lifestyle that were included in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2016. Multivariable regression analysis identified factors significantly associated with the magnitude of NLR after adjusting for comorbidities and medications. Interactions between factors of interest were evaluated, and effect modification by demographic characteristics including age, sex and race was quantified.
Results:
Seven demographic and lifestyle factors were found to be significantly and independently associated with NLR: age, sex, race, marital status, physical activity, smoking history and alcohol use. Females, under 60s and non-Hispanic blacks demonstrated significantly lower NLR than males, over 60s and non-Hispanic whites. Participation in vigorous activity for at least ten minutes at a time was associated with decreased NLR, as was never-smoker status. Moderate drinking was also associated with a decreased NLR as compared to complete abstinence from alcohol.
Conclusions:
Multiple demographic and lifestyle factors are independently associated with elevated NLR. For an accurate assessment of the prognostic power of the NLR in the clinical setting, these factors should be routinely adjusted for in studies of the association between NLR and cancer outcomes. The present study reiterates that physical activity may have the potential to improve clinical outcomes by way of reducing systemic inflammation.
Citation Format: Rachel Howard, Aaron Scheiner, Kathleen M. Egan. Socio-demographic and lifestyle factors associated with the neutrophil-to-lymphocyte ratio: A systematic evaluation of the United States National Health and Nutrition Examination Survey [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3299.
Abstract 3306: Prognostic value of clinical signs at admission in patients with primitive liver cancer at university hospital of Yopougon: Retrospective cohort study
Authors: Tchibozo Djivede Renaud Jutor 
Published: August 2019

Abstract
Introduction: The primitive liver cancer (PLC) is common in Ivory Coast and has a late diagnosis. The PLC has a bad prognosis and few studies have assessed the predictive role of the clinical signs at admission, namely abdominal pain (AD), edematous-ascitic syndrome (OSA), febrile ascites (AF), and Digestive hemorrhage (HD) on the prognosis of patients with PLC .
Objective: To determine the prognostic role of clinical signs in the admission of hospitalized patients for PLC at University Hospital of Yopougon.
Patients And Methods: A retrospective cohort study of 126 patients (average age : 48.2 years, men = 71.4%) hospitalized for PLC at University Hospital of Yopougon from 2012 to 2016 was conducted in the Medicine and Hepato-Gastroenterology Department. For each patient the socio-demographics, clinicals, biologicals and endoscopics data and survival time were collected. These parameters were analyzed by
Kaplan Meier methods and Cox proportional hazards with a significance set at 5%. The risk is expressed in terms of chance ratio (HR) with the confidence interval.
Results: The patients were admitted for DA (32.5%), SOA (50%), AF (7.1%) and HD (10.3). The median duration of follow-up was 0.28 months. The mortality rate was 38.9% (49 of 126 patients) during follow-up. It was 12.7% for AD, 16.7% for SOA, 4.8% for AF and 4.8% for HD. The median overall survival was 0.8 (95% CI: 0.5-1.4) months. It was 0.7 (95% CI: 0.5-2) months for AD, 1.1 (95% CI: 0.4-1.1) months for OSA, 0.3 (95% CI: 0.21-3.6) months for AF and 1.1 (95% CI: 0.6-16.2) months for HD. In multivariate analysis, the predictive factors for mortality were: male sex (HR = 2.12, 95% CI: 1.08-4.17, p = 0.03), AF (HR = 4.51; 95% CI: 1.30 - 15.70, p = 0.02) and the presence of esophageal varicose (HR = 3.43, 95% CI 1.78-6.62, p &lt;0.0001).
Conclusion: Patients suffering from PLC have a higher risk of death due to the presence of febrile ascites or esophageal varicose on admission.
Note: This abstract was not presented at the meeting.
Citation Format: Djivede Renaud Jutor Tchibozo. Prognostic value of clinical signs at admission in patients with primitive liver cancer at university hospital of Yopougon: Retrospective cohort study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3306.
Abstract 3315: Workplace program that offers annual fecal immunochemical testing improves adherence to colorectal cancer screening guidelines
Authors: Tong Carmen H. , Satish Anita , Fragala Maren S. , Bare Lance A. , Birse Charles E. 
Published: August 2019

Abstract
Background: Although regular screening reduces the incidence and mortality of colorectal cancer, ~ 35% of eligible adults remain non-adherent to screening guidelines. We asked if a workplace screening program, using a non-invasive fecal immunochemical test (Insure FIT), would improve adherence to guidelines.
Methods: An employer-sponsored program provided eligible employees (age 50-75 years) the opportunity to participate in colorectal cancer screening. InSure FIT collection kits were mailed annually to: (i) newly eligible employees, (ii) new hires, (iii) those who had participated the previous year and (iv) those who requested testing. Employees returned kits by mail for quantitative detection of human hemoglobin in fecal samples. Those with positive test results were contacted by phone and mail with a recommendation to contact their physician for follow up diagnostic testing. Using a limited data set of health plan claims, we identified those employees, with continuous medical coverage over the 5-year study period (2013-2017), who were adherent to current screening guidelines (colonoscopy any year or FIT every year). Colonoscopy procedures were identified in professional services and outpatient event files using current procedural terminology (CPT) codes.
Results: Approximately a third (32.7%; 1,858/5,686) of eligible employees participated in the program. Some 42.7% (794/1,858) of participants underwent colonoscopy over the 5-year study period. An additional 15.9% (296/1,858) were tested with InSure FIT all 5 years. In total 58.7% (1,090/1,858) of participants were adherent to guidelines (colonoscopy any year or annual FIT). In comparison, only 34.6% (1,323/3,828) of non-participants were adherent to guidelines.
ParticipantsNon-ParticipantsTotal1,8583,828Mean age, y (SD)55.9 (4.2)55.7 (4.3)Female, n (%)1,314 (70.7%)2,470 (64.5%)Adherent to screening guidelines, n (%)1,090 (58.7%)1,323 (34.6%)
Conclusion: Participants in an employer-sponsored FIT program had 24% higher adherence to guidelines for colorectal cancer screening compared to non-participants.
Citation Format: Carmen H. Tong, Anita Satish, Maren S. Fragala, Lance A. Bare, Charles E. Birse. Workplace program that offers annual fecal immunochemical testing improves adherence to colorectal cancer screening guidelines [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3315.
Abstract 3330: Circulating HPV DNA as a biomarker for metastatic cervical cancer detection, genotyping and monitoring
Authors: Kang Zhigang , Stevanović Sanja , Hinrichs Christian , Cao Liang 
Published: August 2019

Abstract
Purpose: Circulating cell-free (cf) human papillomavirus (HPV) DNA is a unique tumor marker for metastatic cervical cancers. We developed a method to genotype and quantify blood circulating HPV DNA in patients with metastatic cervical cancer for patient selection, treatment monitoring, as well as informing data on an experimental T cell therapy.
Patients and Methods: we developed a digital droplet (dd) PCR method for HPV genotyping and quantification with cfDNA. In a retrospective study, HPV cfDNA was measured in serum samples from nine metastatic cervical cancer patients received tumor-infiltrating lymphocyte (TIL) immunotherapy. cfDNA data were aligned with the tumor HPV data, drug treatment, and clinical outcome. In a HPV screening, the genotyping and DNA copy number of HPV cfDNA from 47 cervical cancer patients were measured and the allele frequencies were determined in relative to total genomic cfDNA of each patient.
Results: The ddPCR assay is highly sensitive, specific, and capable of accurate quantification of both HPV16 and HPV18 cfDNA. In the clinical validation, we detected HPV cfDNA from 19/19 (100%) patients with HPV-positive metastatic and recurrent cervical cancer but not in any of the 45 healthy blood donors. The HPV genotype harbored in the patients’ tumors was correctly identified in 87/87 (100%) sequential patient serum samples. Our data showed the use of HPV cfDNA for pharmacokinetic studies, effectiveness on an investigational therapy, and patient monitoring. In three patients who experienced objective responses, a transient HPV cfDNA peak was detected 2-3 days after TIL immunotherapy and a persistent clearance of HPV cfDNA was observed in only two patients with a complete response (CR). Among the HPV positive cases, the median HPV cfDNA allele frequency is above 30% of genomic single copy genes in these cervical cancer patients.
Conclusions: We developed and validated a highly sensitive and specific HPV cfDNA genotyping and quantification method. As a promising non-invasive tumor marker, HPV cfDNA may have value in detecting the efficacy of therapeutic agents and monitoring cervical cancer patients in remission. The cfDNA based HPV genotyping is currently being evaluated for patient selection in an experimental T-cell therapy against a specific HPV antigen. HPV cfDNA may also be a potential biomarker for early diagnosis of cervical cancer.
Citation Format: Zhigang Kang, Sanja Stevanović, Christian Hinrichs, Liang Cao. Circulating HPV DNA as a biomarker for metastatic cervical cancer detection, genotyping and monitoring [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3330.
Abstract 3334: Predictive therapeutic value of NGS with liquid biopsy in metastatic NSCLC
Authors: Tomao Silverio , Verrico Monica , Rossi Luigi , Stefano Iacobelli 
Published: August 2019

Abstract
Analysis of circulating tumor cells ( CTCs) and circulating cell-free DNA (cfDNA), detected in peripheral blood of patients, is an extraordinary novel strategy to identify and study NSCLC patients, in order to obtain prognostic and predictive molecular informations with a simple, non invasive and sensitive method. Liquid biopsy therefore offers a new source of cancer cells and cancer-derived materials in order to test more personalized treatment. With two PCR-based next generation sequencing (NGS) approaches we evaluated 45 patients with not squamous NSCLC ; in eighteen pts ( 40 % ) almost one genomic mutation was detected among 56 different genes analyzed with NGS. Median age of patients was 69 years ( 55-78) and 14 (73%) were males. Altogether, 11 genes were mutated with a panel of 56 genes analyzed (19,6% ) . The most frequent mutations occurred in KRAS, TP53, MET,KDR, KIT, SMAD4 and MET genes. Several patients expressed many mutations and the most frequent detected concerned gen c-Kit ( 22%). Other mutations concerned the following genes : TP53 ( 16 % ), MET/KDR. / SMAD4/KRas ( 44%). Other genomic alterations concerned the following genes: JACK3 (5%); APC(5%); ERBB4(5%); CTNNB! (5%); EGFR (5%). Altogheter the response to therapy was higher among patients with mutation of Smad 4 gene and lower in patients with mutations of KIT gene. All side effects occurred with target therapy was categorized according to the Common Terminology Criteria for Adverse Events, 4.0 version. An increase of gastroenteric (G3/G4) and hematologic toxicity (G3/G4) was observed in patients with Kit mutations. In our study this correlation was observed mainly during treatment with Tyrosine Kinase Inhibitors (TKIs ).Evaluating Progression Free Survival (PFS) in all the patients recruited in the study, a median PFS of 12.5, 11.5, 4 and 9 months was observed respectively in patients with mutations of KIT, SMAD4, TP53 and MET. In this study, all the genetic alterations analyzed and highlighted were related to the response to chemotherapeutic treatments and possible tyrosine kinase inhibitory treatments in terms of PFS and toxicity.
Note: This abstract was not presented at the meeting.
Citation Format: Silverio Tomao, Monica Verrico, Luigi Rossi, Iacobelli Stefano. Predictive therapeutic value of NGS with liquid biopsy in metastatic NSCLC [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3334.
Abstract 3349: Collected experiences of young-onset colorectal cancer caregivers
Authors: Newcomer Kimberley L. , Yarden Ronit , Advisory Never Too Young 
Published: August 2019

Abstract
The Colorectal Cancer Alliance launched a survey for caregivers of young-onset colorectal cancer (CRC) patients and survivors. A caregiver of young-onset CRC is an unpaid or paid member of a person's social network who helps them with activities of daily living. Caregivers who participated in our survey (n=427) are diverse: in age, gender, and racial/ethnic group. The majority of them were between the ages of 30-39. The caregivers reported they faced many challenges including lack of resources and information on young-onset disease and the course of the disease progression. Also, many caregivers indicated they had difficulty understanding the different treatment options offered by the physicians as well as the risk and long-term side-effects associated with these aggressive treatments. Only 40 percent of providers talked to patients about genetic testing and explained to the patient's family member their elevated risk of the disease and the associated need for timely screening. The majority of caregivers (59%) reported that their loved one experienced changes in their ability to perform expected social tasks, including those of a spouse, child rearer, friend, or worker. Some caregivers also mentioned the loss of sexuality, depression, pain, despair, lack of sleep, sadness, and stress, along with a loss of faith and hope, which may cause additional strain on their relationships. Thirty-two percent of caregivers reported insufficient psychosocial (66%) and financial support (44%) to effectively care for their patients. Participants also indicated that resources such as transportation, child care, household maintenance, prevention, and surveillance information for family members are limited. Overall, about one in three caregivers reported they were missing 24 hours or more of work each month to care for their loved one. A caregiver stated she needed, “Emotional and basic help around the house with her children and someone responsible enough to stay in the house to understand what we were going through as a family.” Taken together, our survey indicates that additional resources are needed to improve the ability for caregivers to manage everyday tasks, potentially helping caregivers feel more organized and in control. The ability of caregivers to care for themselves and use tools to care for their loved ones will reduce emotional and physical demands involved with caregiving that can cause strain and burnout. The Alliance will use these survey results to learn about and track the self-reported medical, psychosocial, and quality of life experiences of this often overlooked group.
Citation Format: Kimberley L. Newcomer, Ronit Yarden, Never Too Young Advisory. Collected experiences of young-onset colorectal cancer caregivers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3349.
Abstract 3364: A study to assess the critical result reporting of the patients diagnosed with cancer at B&C Medical College and Teaching Hospital
Authors: Sharma Sujan 
Published: August 2019

Abstract
Objective: This critical value can occur while performing panels of tests at laboratory by different chemistry or blood analysers with varieties of principles. The main objective of the study was to study the process of critical result reporting and to know the way of communication and documentation done for critical value in the laboratory, ICUs and the wards.Methods: This study was prospective and non-experimental was conducted at B&C Medical College and Teaching Hospital from 14.04.2018 to 14.05.2018 . Total 60 critical values samples were included. The data was collected by means of observing the critical values of inpatient and the process of reporting from the laboratory to the respective wards and ICUs.Results: Out of 60 samples included in our study, there was 100% communication to concerned treating units. For the confirmation of critical value repeat test was done in 68% of cases. In 75% of cases clinicians did follow up. Recording of a critical report in lab was done in 96% of cases and almost all of the critical values 98% were immediately reported to the respective wards by technical staffs. There was no communication in 1.6% of cases to treating units by technical staff. Majority 78% of critical values were communicated by respective wards and ICUs nurses to concerned doctors.Conclusion: Critical value can occur while performing panels of tests at laboratory and reporting such values to treating clinicians or respective wards or ICUs could help heath care providers for effective treatment of the patients and their adequate care.
Note: This abstract was not presented at the meeting.
Citation Format: Sujan Sharma. A study to assess the critical result reporting of the patients diagnosed with cancer at B&C Medical College and Teaching Hospital [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3364.