bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventional therapy in patients with severe emphysema: evaluation of contraindications and their incidence
Authors: Polke Markus , Rötting Matthias , Sarmand Nilab , Krisam Johannes , Eberhardt Ralf , Herth Felix J.F. , Gompelmann Daniela 
Published: March 2019

Background: Endoscopic and surgical interventions may be beneficial for selected patients with emphysema. Rates of treatment failure decrease when the predictors for successful therapy are known. The aim of the study was to evaluate the number of patients with severe emphysema who were not eligible for any intervention, and the reasons for their exclusion. Methods: The study was a retrospective analysis of 231 consecutive patients with advanced emphysema who were considered for interventional therapy in 2016 at the Thoraxklinik, Heidelberg, Germany. The reasons for not receiving valve or coil therapy were assessed for all patients who did not receive any therapy. Results: Of the 231 patients, 50% received an interventional therapy for lung volume reduction (LVR) (82% valve therapy, 6% coil therapy, 4.3% polymeric LVR or bronchial thermal vapour ablation, 4.3% total lung denervation, and 3.4% lung volume reduction surgery [LVRS]). A total of 115 patients did not undergo LVR. Out of these, valve or coil therapy was not performed due to one or more of the following reasons: incomplete fissure in 37% and 0%; missing target lobe in 31% and 30%; personal decision in 18% and 28%; pulmonary function test results in 8% and 15%; ventilatory failure in 4% and 4%; missing optimal standard medical care and/or continued nicotine abuse in 4% and 3%; general condition too good in less than 1% and 3%; cardiovascular comorbidities in 0% and 3%; age of patient in 0% and less than 1%. Both techniques were not performed due to one or more of the following reasons: solitary pulmonary nodule(s)/consolidation in 27%; bronchopathy in 7%; neoplasia in 2%; destroyed lung in 2%; prior LVRS in less than 1%. Conclusions: The main reason for not placing valves was an incomplete fissure and for coils a missing target lobe. Numerous additional contraindications that may exclude a patient from interventional emphysema therapy should be respected.
Interdevice agreement in respiratory resistance values by oscillometry in asthmatic children
Authors: Ducharme Francine M. , Jroundi Imane , Jean Guillaume , Lavoie Boutin Guillaume , Lawson Christiane , Vinet Benjamin 
Published: March 2019

BackgroundWith several commercially available devices measuring respiratory impedance by oscillometry, the agreement between values obtained on different instruments or frequencies remains unclear. Our aim was to examine the agreement between resistance and reactance parameters on two oscillometry instruments using different waveforms.MethodsWe conducted a prospective cross-sectional study in asthmatic children aged 3–17 years. Reproducible oscillometry measurements were obtained in random order, by blinded operators, at three modes: 5–10–15–20–25 Hz (5–25 Hz) multifrequency mode on the MasterScreen impulse oscillometry system, and both 5–25 Hz multifrequency mode and 7 Hz monofrequency on the tremoFlo C-100 airwave sinusoidal system. Resistance, reactance and within-breath parameters were examined using the intraclass correlation coefficient (ICC), paired t-test, linear regression and Bland–Altman method.ResultsOf 50 participants, 44 and 38 completed between-device and within-frequency measurements, respectively. Between-device measurements at 5–25 Hz showed high (ICC 0.88–0.91) and good (ICC 0.69–0.87) agreement in resistance and reactance, respectively, but with an absolute within-patient difference (≥0.05 kPa·L−1·s−1) and proportional bias (≥30% per kPa·L−1·s−1) in all parameters and oscillatory frequencies, apart from resistance at 5 Hz.A significant proportional bias was documented in most within-breath parameters at 5versus7 Hz on tremoFlo.ConclusionObserved differences in resistance and reactance suggest the need for instrument- and frequency-specific paediatric normative values.
Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study
Authors: Dieckmann Klaus-Peter , Radtke Arlo , Geczi Lajos , Matthies Cord , Anheuser Petra , Eckardt Ulrike , Sommer Jörg , Zengerling Friedemann , Trenti Emanuela , Pichler Renate , Belz Hanjo , Zastrow Stefan , Winter Alexander , Melchior Sebastian , Hammel Johannes , Kranz Jennifer , Bolten Marius , Krege Susanne , Haben Björn , Loidl Wolfgang , Ruf Christian Guido , Heinzelbecker Julia , Heidenreich Axel , Cremers Jann Frederik , Oing Christoph , Hermanns Thomas , Fankhauser Christian Daniel , Gillessen Silke , Reichegger Hermann , Cathomas Richard , Pichler Martin , Hentrich Marcus , Eredics Klaus , Lorch Anja , Wülfing Christian , Peine Sven , Wosniok Werner , Bokemeyer Carsten , Belge Gazanfer 
Published: March 2019

PURPOSE Previous studies suggested that serum levels of microRNA (miR)-371a-3p (so-called M371 test) have a much higher sensitivity and specificity than the classic markers of testicular germ cell tumors (GCTs) and are applicable toward both seminoma and nonseminoma. We sought to confirm the usefulness of this test as a novel biomarker for GCT. PATIENTS AND METHODS In a prospective, multicentric study, serum samples of 616 patients with testicular GCTs and 258 male controls were examined for serum levels of miRNA-371a-3p (miR levels) by quantitative polymerase chain reaction. The GCT population encompassed 359 patients with seminoma and 257 with nonseminoma; 371 had clinical stage I disease, 201 had systemic disease, and 46 had relapses. Paired measurements before and after orchiectomy were performed in 424 patients; 118 with systemic disease had serial measurements during treatment. miR levels were compared with those of β-human chorionic gonadotropin, α-fetoprotein, and lactate dehydrogenase. RESULTS For the primary diagnosis of GCT, the M371 test showed a sensitivity of 90.1%, a specificity of 94.0%, an area under the curve of 0.966 upon receiver operating characteristic analysis, and a positive predictive value of 97.2%. α-Fetoprotein, β-human chorionic gonadotropin, and lactate dehydrogenase had sensitivities of less than 50% in seminoma and slightly higher sensitivities in nonseminomas. miR levels were significantly associated with clinical stage, primary tumor size, and response to treatment. Relapses had elevated miR levels that subsequently dropped to normal upon remission. Teratoma did not express miR-371a-3p. CONCLUSION The M371 test outperforms the classic markers of GCT with both a sensitivity and a specificity greater than 90%. All histologic subgroups, except teratoma, express this marker. The test could be considered for clinical implementation after further validation.
Dynein activators and adaptors at a glance
Authors: Olenick Mara A. , Holzbaur Erika L. F. 
Published: March 2019

ABSTRACT
Cytoplasmic dynein-1 (hereafter dynein) is an essential cellular motor that drives the movement of diverse cargos along the microtubule cytoskeleton, including organelles, vesicles and RNAs. A long-standing question is how a single form of dynein can be adapted to a wide range of cellular functions in both interphase and mitosis. Recent progress has provided new insights – dynein interacts with a group of activating adaptors that provide cargo-specific and/or function-specific regulation of the motor complex. Activating adaptors such as BICD2 and Hook1 enhance the stability of the complex that dynein forms with its required activator dynactin, leading to highly processive motility toward the microtubule minus end. Furthermore, activating adaptors mediate specific interactions of the motor complex with cargos such as Rab6-positive vesicles or ribonucleoprotein particles for BICD2, and signaling endosomes for Hook1. In this Cell Science at a Glance article and accompanying poster, we highlight the conserved structural features found in dynein activators, the effects of these activators on biophysical parameters, such as motor velocity and stall force, and the specific intracellular functions they mediate.
Osteonecrosis of the femoral head: pathophysiology and current concepts of treatment
Authors: Petek Daniel , Hannouche Didier , Suva Domizio 
Published: March 2019

Osteonecrosis of the femoral head is a disabling pathology affecting a young population (average age at treatment, 33 to 38 years) and is the most important cause of total hip arthroplasty in this population. It reflects the endpoint of various disease processes that result in a decrease of the femoral head blood flow. The physiopathology reflects an alteration of the vascularization of the fine blood vessels irrigating the anterior and superior part of the femoral head. This zone of necrosis is the source of the loss of joint congruence that leads to premature wear of the hip. Several different types of medication have been developed to reverse the process of ischemia and/or restore the vascularization of the femoral head. There is no consensus yet on a particular treatment. The surgical treatments aim to preserve the joint as far as the diagnosis could be made before the appearance of a zone of necrosis and the loss of joint congruence. They consist of bone marrow decompressions, osteotomies around the hip, vascular or non-vascular grafts. Future therapies include the use of biologically active molecules as well as implants impregnated with biologically active tissue.Cite this article: EFORT Open Rev 2019;4:85-97. DOI: 10.1302/2058-5241.4.180036
BAHASA DAN KELAHIRANNYA
Authors: Herniti Ening 
Published: March 2019

Language is a unique trait, which differentiates human being from other creatures. Language ability is a human nature whereas other creatures share their communication system. A study on chimpanzee proves that language only works on human. The study depicts that language is a one of the most primary characteristics of human nature. Chomsky calls it as language acquisition tool. Philosophical and scientific speculation on the function of language in man was frequent throughout history, dating back to the age of Plato and Aristotle. Yet those speculations have been approached more often by scientists than philosophers. Many theories propose that the gains to be had from language and/or reason were probably mainly in the area of increasingly sophisticated social structures.
FITUR-FITUR FONOLOGIS PENGGUNAAN ELEMEN-ELEMEN BAHASA ARAB DALAM KOMUNIKASI MASYARAKAT KETURUNAN ARAB SURAKARTA
Authors: Fauziah Jiah 
Published: March 2019

This qualitative research is aimed at describing the phonological features of the Arabic elements used in the communication of the Arabic migrant community of Surakarta. It is assumed that the long contact with Austronesian languages, i.e. Indonesian and Javanese, as languages of the majority gives significant influence on the language they maintain from their ancestors. The main data are the lexicon list of the Arabic elements used in the community, and the supporting data are the system of classical/ standard Arabic and information on their ancestors’ Arabic dialect as a comparison. To get the lexicon data of the Arabic in Surakarta, the interview is done, whereas the data of the system of Classical Arabic and the ancestors’ dialect are gathered using interview and library research methods. In the analysis, the writer applies comparative method using the theory of language change. After examining closely and analyzing the data, the writer comes to a conclusion that the Arabic language elements used in the Arabic migrant group in Surakarta has undergone several phonological modifications in which most of the features show strong influences of the language of the majority, and some shows the modification of their ancestors’ dialect.
STRUKTUR NARATIF CERITA NABI KHIDIR DALAM AL-QUR’AN
Authors: Faisol M. 
Published: March 2019

This article aims at studying narrative structure of the story of Saint Khidir (Nabi Khidir) in the Koran by questioning its meaning, its structure and fuction. The narrative approach is used in examining the story. It turns out that like any other stories in the Koran, the story of saint Khidir has a simple structure of narrative (ijaz). The narrative structure of the story aims at strengthening the faith to Alloh through its thematic values. The story also informs us the social context of the given time and prophet Mohammad’s psychological realm in his preaching. The story gives tremendous moral value to Arabic society in giving meaning to their selves and their surroundings.
Trade-offs de custos logísticos: uma avaliação de conhecimento em uma multinacional
Authors: Da Silva José Alan Barbosa , Schlag Fabricio , Silva Solange da 
Published: March 2019

Este artigo objetivou verificar a extensão com que os profissionais de logística verificam e analisam seu custo total e os níveis de serviços e se conhecem seus trade-offs. A metodologia compreende revisão bibliográfica e um estudo de caso realizado em uma multinacional, uma das maiores empresas mundial de fragrâncias, cosméticos, beleza e maquiagem. Os dados obtidos demonstraram que os profissionais de logística têm ciência de que, a logística gera impacto econômico-financeiro na organização. Quanto a experiência e a educação formal, evidenciou-se que, favorecem positivamente a identificação de problemas e a eliminação de parte dos erros e retrabalhos, porque amplia a base de sabedoria dos profissionais. Referente a informações contábeis e logísticas, comprovou-se a falta de informações adequadas e suficientes para a gestão logística da organização. Conclui-se que os profissionais, precisam receber informações logísticas e contábeis que auxiliarão na tomada de decisão e busca do nível de serviço ótimo versus custo total mínimo.
Vloga medicinske sestre z naprednimi znanji pri zdravstveni obravnavi mladostnikov s samopoškodovalnim vedenjem brez samomorilnega namena
Authors: Krnel Tilen Tej 
Published: March 2019

Uvod: Duševno zdravje je pri mladostnikih lahko okrnjeno zaradi samopoškodovalnega vedenja v različnih oblikah. Namen raziskave je bil identificirati specifične vloge medicinske sestre z naprednimi znanji pri zdravstveni obravnavi mladostnikov s samopoškodovalnim vedenjem brez samomorilnega namena.Metode: Uporabljeni sta bili metoda pregleda literature in metoda tematske analize izbranih virov z oblikovanjem kod, kategorij ter tematskih področij. Po elektronskih podatkovnih bazah CINAHL, MEDLINE in ERIC je iskanje potekalo s pomočjo ključnih besed »samopoškodovanje«, »adolescenca« in »napredna zdravstvena nega« v angleškem prevodu. Glavna vključitvena kriterija sta bila osredotočanje na intervencije zdravstvene nege pri samopoškodovalnem vedenju ter obdobje adolescence. Tematska analiza je potekala na način odprtega kodiranja, kjer so enoto kodiranja predstavljale ključne ugotovitve izbranih virov.Rezultati: Predlagane vloge medicinske sestre z naprednimi znanji pri zdravstveni obravnavi mladostnika s samopoškodovalnim vedenjem brez samomorilnega namena so: specializirana klinična ocenjevalka, izvajalka presejalnih programov, promotorka duševnega zdravja, začetnica specializirane obravnave, izvajalka specifičnih intervencij, preprečevanje samopoškodovalnega vedenja, sodelovanje v interdisciplinarnem timu ter izvajanje izobraževanj.Diskusija in zaključek: Treba bo razviti klinično pot obravnave mladostnika s samopoškodovalnim vedenjem brez samomorilnega namena in intervencije zdravstvene nege, podprte z dokazi. Prav medicinske sestre so pri tem v edinstvenem položaju, saj jih mladostniki pogosto izberejo raje kot ostale strokovnjake, kar predstavlja izreden potencial za razvoj vloge medicinske sestre z naprednimi znanji na področju duševnega zdravja mladostnikov.
Attitudes towards spirituality and spiritual care among nursing employees in hospitals
Authors: Montanič Starc Tanja , Karnjuš Igor , Babnik Katarina 
Published: March 2019

Introduction: Understanding spirituality and spiritual care is a prerequisite for holistic care. The research goal was to describe nurses' attitudes towards spirituality and spiritual care.Methods: The study was carried out between 2015 and 2016 using a quantitative non-experimental method. The Spirituality and Spiritual Care Rating Scale Questionnaire was given to a sample of 182 nursing care employees, mostly women (n = 153, 88.4 %), with completed higher (n = 93, 53.8 %) or secondary (n = 75, 43.4 %) education, from four Slovenian hospitals. The questionnaire had adequate internal consistency (Cronbach alpha = 0.83).Results: The highest agreement (x = 4.27, s = 0.82) was reached on the statement which describes spiritual care as respecting patient's privacy, dignity, cultural and religious beliefs. Participants also agreed with the statement that they provide spiritual care by demonstrating kindness, care, and cheerfulness (x = 4.2, s = 0.76), but they expressed uncertainty about the statement that spirituality and spiritual care are fundamental aspects of nursing care (x = 2.88, s = 1.08).Discussion and conclusion: Participants connect spirituality with an understanding of themselves and the world, rather than only with religion and sacral objects. The research has confirmed the findings of previous Slovenian studies that nurses give priority to meeting patients' physical needs before spiritual ones probably also as a result of a lack of knowledge and professional guidance on spiritual care.
REFORMASI ADMINISTRASI PELAYANAN PUBLIK (STUDI PELAYANAN ADMINISTRASI TERPADU KECAMATAN JAWA TENGAH)
Authors: Nugroho Sulistiyo Ardi , Kismartini Kismartini , Purnaweni Hartuti 
Published: March 2019

Percepatan reformasi administrasi di daerah adalah mewujudkan tata kelola pemerintahan daerah yang baik (good localgovernance) yang terfokus pada peningkatan kualitas penyelenggaraan pelayanan publik. Didalam meningkatkan kualitas penyelenggaraan pelayanan publik diperlukan inovasi pelayanan publik. Pelayanan Administrasi Terpadu Kecamatan (PATEN) merupakan inovasi sederhana untuk melaksanakan reformasi Administrasi di tingkat daerah (local), khususnya di Kecamatan. Penelitian Reformasi Administrasi Pelayanan Publik (Studi Pelayanan Administrasi Terpadu Kecamatan di Jawa Tengah ) ini menggunakan metode penelitian kualitatif – diskriptifAnalisa data dilakukan melalui tahap reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian Pelaksanaan Pelayanan Administrasi Terpadu Kecamatan (PATEN) di Jawa Tengah telah 0.Tengah. Dengan persyaratan PATEN yaitu syarat substantif, administratif dan teknis telah mendorong Bupati/Walikota di Jawa Tengah untuk melimpahakan kewenanganya kepada camat dan memperkuat peran dan fungsi Kecamatan. Tidak hanya sebagai Satuan Kerja Perangkat Daerah dan pelaksanana tugas pemerintahan umum, namun juga melaksanakan peran fungsi sebagai unit pelayanan terpadu di Kecamatan. Hal ini telah membuat kecamatan menjadi sangat strategis di tingkat Kabupaten/Kota, yaitu menjadi simpul pelayanan terpadu bagi Kantor/Badan Pelayanan Terpadu di Kabupaten.Dengan adanya PATEN di Jawa Tengah, membuat Kecamatan – Kecamatan di Jawa Tengah memiliki visi, misi, maklumat pelayanan, Standart Operating Procedure (SOP) sehingga tingkat akuntabilitas dan budaya kerja di Kecamatan meningkat. Hal lain yang menonjol pada umumnya dengan pelaksanaan PATEN adalah peningkatan sarana prasarana pelayanan.
PEMINDAHAN TAPING FASA UNTUK PENYEIMBANGAN BEBAN PADA JARINGAN 3 FASA DENGAN MENDETEKSI ARUS NETRAL BERBASIS ARDUINO MEGA 2560
Authors: Wicaksana Pandu , Manan Saiful 
Published: March 2019

Pandu Wicaksana, Saiful Manan, in this paper explain that the load balance on the 3 phase 4 wire distribution system is very important. Continuous load imbalances can cause a decrease in the reliability of the electric power system and the quality of electrical energy. One consequence of an unbalanced load is the presence of a current flowing in a neutral introduction. The purpose of this study is to find out and analyze the current in a neutral conductor when the load conditions are unbalanced and when balanced. Load balancing is done by manual-remote, which means that the transfer of taping at a load is done by pressing the button that has been integrated with the HMI display. This software is also responsible for displaying current output from the sensor. That way, it can be seen that the current value of the neutral conductor before and after load balancing is done. That the current value of the neutral conductor will be smaller when the load is balanced compared to when the load between phases is not balanced. Keywords: Unbalanced Load, Neutral Flow, SCADA, load balancingReferencesUtami ,Purwanti Bekti. 2016. Studi Kasus Ketidakseimbangan Beban Dengan Perubahan Taping 1 Fasa Pada Penyulang Kalisari 05 Pt. Pln (Persero) Rayon Semarang Tengah. Tugas Akhir Tidak Terpublikasi. Semarang: Universitas Diponegoro.Desiana, Catur. 2015. Perhitungan Susut Daya Listrik dan Simulasi Software ETAP 12.6.0 GunaMenjaga Mutu Tegangan di DaerahSawah Besar Raya Kaligawe Penyulang PDL.13 PT.PLN (Persero) Rayon Semarang Timur.Tugas Akhir Tidak Terpublikasi. Semarang: Universitas DiponegoroGhani, Reza Muhammad. 2016. Alat Pendeteksi Terputusnya Aliran Listrik Pada Jaringan Tegangan Menengah Satu Fasa Menggunakan Arduino Mega 2560 Dengan Memanfaatkan Aplikasi Web. Tugas Akhir Tidak Terpublikasi. Semarang: Universitas Diponegoro.Arduino & Genuino Products. Arduino MEGA 2560 & Genuino MEGA2560. https://www.arduino.cc/en/Main/arduinoBoardMega2560. Diakses tanggal 26 Juni 2017.
SIMULASI SISTEM PERINGATAN DINI KETINGGIAN AIR SUNGAI DENGAN MENGGUNAKAN ALARM DAN SMS GATEWAY BERBASIS AT-MEGA 16
Authors: Firdaus Muhammad , Yuniarto Yuniarto 
Published: March 2019

Muhammad Firdaus, Yuniarto, in this paper explain that river is one of the important and supporting places for human life, some uses of the river include supporting industrial activities, tourism and much more, besides that many in some river function sites are used as dams for use as an area of electricity generation or just for control water content, but from rivers also natural disasters can occur, which is like a flood caused by overflowing river water The alert system will flood from overflowing rivers until now it cannot work automatically to determine the river's water level. This causes the average local population not to know when the river surface will overflow. In this study a flood detection system was designed that works automatically by knowing the level (level) of the river's water level In designing this tool, the system will be made on the basis of the Atmega 16 microcontroller, where as an input electrodes will be used as detection of water level, and the output will be an alarm with a certain type of sound that adjusts the water level. destination number in the form of notification of the condition of the river water level to be detected. Keywords: Monitoring system, water level, electrodeReferencesIonisasi’,Available:https://id.wikipedia.org/wiki/Ionisasi [04, Juni, 2017]Utami Budi,et.al, Kimia Edisi 1, Jakarta : Pusat Perbukuan Departemen Pendidikan Nasional, 2009Utami Budi,wt.al, Edisi 2, Jakarta : Pusat Perbukuan Departemen Pendidikan Nasional, 2009Winoto Ardi, Mikrokontroller AVR ATmega 8/32/16/8535 dan Pemrogamannya dengan Bahasa C pada WinAVR, Bandung : INFORMATIKA (IF)----, 2006, Data Sheet Mikrokontroller AT-Mega16(L), Atmel.Floyd, T., Principles of Electric circuits conventional current vertion 8th Edition, New Jersey, Hal. 486-496Purnama, A, 2012, Elektronika Dasar, Available http://elektronika-dasar.web.id/ [04,Juni, 2017]Cathey, JJ., Schaum’s Outlines Electronic Devices and Circuits 2nd Edition, USA, Hal. 70-71, 2002Boylestad, R, and Nashelsky, L, Electronic Device and Circuit Theory 7th Edition, Ohio, Hal. 180-185Buzzer, 2007,Available : http://elektronika-elektronika.blogspot.co.id/2007/04/Buzzer.html, [30, Mei, 2017]Imersa Lab , Sistem Minimum Mikrokontroller, http://www.immersa-lab.com/sistem-minimum-mikrokontroler.html [07, juni, 2017]