bluuebunny/crossref_metadata_2025_split huggingface dataset:
A SECOND‐ORDER SYNCHROSQUEEZING S‐TRANSFORM AND ITS APPLICATION IN SEISMIC SPECTRAL DECOMPOSITION
Authors: Zhong‐Lai HUANG , Jian‐Zhong ZHANG , Zhi‐Hui ZOU 
Published: February 2018

AbstractThe Synchrosqueezing S‐transform (SSST) is a novel approach for time‐frequency (T‐F) representation of non‐stationary signals. By “squeezing” T‐F spectrum of the S‐transform (ST) of a signal, the SSST can obtain a high‐resolution T‐F spectrum. However, when the phase of a signal varies non‐linearly with time, the instantaneous frequency (IF) of the signal calculated by the SSST would be inaccurate, causing reduction of the resolution of the T‐F spectrum. In order to improve its performance in imaging such signals, we modify the formula of IF with the help of the second‐order partial derivatives of time and frequency, and propose a second‐order Synchrosqueezing S‐transform (SSST2nd). Synthetic examples show that the SSST2nd not only has obviously higher resolution than commonly used T‐F transforms, but also images the signals of which the IFs vary quadratically or sinusoidally with time better than the SSST. We apply the SSST2nd to perform spectral decomposition of seismic data for natural gas exploration. The results illustrate that the SSST2nd can be used to well detect frequency spectral anomalies correlated with natural gas accumulations. Therefore, it can be concluded that the SSST2nd is a good potential technique for seismic interpretation.
DECREASING RADIUS ITERATIVE METHOD FOR REGIONAL‐RESIDUAL SEPARATION OF POTENTIAL FIELD DATA
Authors: Dong‐Jia LIU 
Published: February 2018

AbstractA decreasing radius iterative method in spatial domain is presented for regional‐residual separation of potential field data. A new eight‐point circumference average formula is derived by arithmetical average of potential field values at eight points along the circumference of a circle of given radius, which can be seen as a filter for calculating regional anomaly from gravity or magnetic data. The transfer function of the filter has a main lobe and multiple side lobes. When the radius becomes large, the number of the side lobes increases, and the filter characteristics become bad. The product of the transfer functions for various values of the radius from large to small is constructed, which is defined as decreasing radius iterative transfer function herein, with the largest radius as its parameter. The decreasing radius iterative transfer function is similar to the low‐pass filter, and the cut‐off wave number is inversely proportional to the largest radius. Based on the decreasing radius iterative transfer function, the decreasing radius linear iterative method in spatial domain is presented for separating regional anomaly, and the residual anomaly is obtained by subtracting the regional anomaly from the gravity or magnetic data. Furthermore, by constructing the nonlinear correction coefficient, the linear iterative formula of the decreasing radius linear iterative method is transformed into the nonlinear iterative formula, and the decreasing radius nonlinear iterative method in spatial domain is proposed. The decreasing radius nonlinear iterative method is tested with synthetic data from model and a field data set from the Nihe iron deposit in Anhui Province. The results show that the proposed method effectively suppresses false anomaly and high frequency interference, reduces anomaly distortion, and separates regional anomaly and residual anomaly from the gravity and magnetic data.
FINITE‐ELEMENT MODELING OF 3D MCSEM IN ARBITRARILY ANISOTROPIC MEDIUM USING POTENTIALS ON UNSTRUCTURED GRIDS
Authors: Han‐Bo CHEN , Tong‐Lin LI , Bin XIONG , Shuai CHEN , Yong‐Liang LIU 
Published: February 2018

AbstractThis paper presents a new algorithm for the three‐dimensional marine controlled source electromagnetic method modeling in arbitrarily anisotropic medium based on unstructured grids and coulomb gauge. In order to avoid the effect of source singularity, we apply the secondary potential formulation for the quasi‐static of Maxwell's equation. Next, solving the finite element equations with IDR(s) iterative algorithm method combined with the incomplete LU decomposition technology. Once the secondary vector and scalar potential is solved, we can use the moving least square method to calculate their spatial derivative and compute the secondary electric and magnetic field. In order to test the finite element method for numerical modeling of 3D controlled source electromagnetic data in an arbitrarily anisotropic conductive medium of this paper, we applied the developed algorithm to compute the typical CSEM response of two 3D models. The modeling results show that the proposed algorithm is feasible and effective; the IDR(s) is competitive with or superior to ILU‐QMR, ILU‐BICGSTAB methods; the proposed algorithm is general and can be applied to EM modeling in borehole and environment geophysics in arbitrarily anisotropic medium.
Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters
Authors: Neiens Patrick , De Simone Angela , Höfner Georg , Wanner Klaus T. 
Published: February 2018

AbstractIn this work, we present label‐free, mass‐spectrometry‐based binding assays (MS Binding Assays), targeting the human dopamine, norepinephrine, and serotonin transporters (hDAT, hNET, and hSERT) in simultaneous binding experiments. Using a validated LC–ESI‐MS/MS method for quantification of the selective dopamine transporter inhibitor (R,R)‐4‐(2‐benzhydryloxyethyl)‐1‐(4‐fluorobenzyl)piperidin‐3‐ol ((R,R)‐D‐84), the selective norepinephrine transporter inhibitor (S,S)‐reboxetine, and the selective serotonin reuptake inhibitor (S)‐citalopram, binding affinities at the three monoamine transporters could be characterized simultaneously in a single binding experiment. The performed simultaneous saturation and competition experiments yielded results that are in good accordance with those determined in MS Binding Assays addressing the monoamine transporters individually. The results obtained from this study underscore the potential of MS Binding Assays for simultaneous affinity determination at different targets, which is difficult to accomplish with conventional radioligand binding assays.
Development of a Focused Library of Triazole‐Linked Privileged‐Structure‐Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections
Authors: Uliassi Elisa , Piazzi Lorna , Belluti Federica , Mazzanti Andrea , Kaiser Marcel , Brun Reto , Moraes Carolina B. , Freitas‐Junior Lucio H. , Gul Sheraz , Kuzikov Maria , Ellinger Bernhard , Borsari Chiara , Costi Maria Paola , Bolognesi Maria Laura 
Published: February 2018

AbstractProtozoan infections caused by Plasmodium, Leishmania, and Trypanosoma spp. contribute significantly to the burden of infectious diseases worldwide, causing severe morbidity and mortality. The inadequacy of available treatments calls for cost‐ and time‐effective drug discovery endeavors. To this end, we envisaged the triazole linkage of privileged structures as an effective drug design strategy to generate a focused library of high‐quality compounds. The versatility of this approach was combined with the feasibility of a phenotypic assay, integrated with early ADME‐tox profiling. Thus, an 18‐membered library was efficiently assembled via Huisgen cycloaddition of phenothiazine, biphenyl, and phenylpiperazine scaffolds. The resulting 18 compounds were then tested against seven parasite strains, and counter‐screened for selectivity against two mammalian cell lines. In parallel, hERG and cytochrome P450 (CYP) inhibition, and mitochondrial toxicity were assessed. Remarkably, 10‐((1‐(3‐([1,1′‐biphenyl]‐3‐yloxy)propyl)‐1H‐1,2,3‐triazol‐5‐yl)methyl)‐10H‐phenothiazine (7) and 10‐(3‐(1‐(3‐([1,1′‐biphenyl]‐3‐yloxy)propyl)‐1H‐1,2,3‐triazol‐4‐yl)propyl)‐10H‐phenothiazine (12) showed respective IC50 values of 1.8 and 1.9 μg mL−1 against T. cruzi, together with optimal selectivity. In particular, compound 7 showed a promising ADME‐tox profile. Thus, hit 7 might be progressed as an antichagasic lead.
Design, Synthesis, and Biological Evaluation of Bivalent Ligands Targeting Dopamine D2‐Like Receptors and the μ‐Opioid Receptor
Authors: Qian Mingcheng , Vasudevan Lakshmi , Huysentruyt Jelle , Risseeuw Martijn D. P. , Stove Christophe , Vanderheyden Patrick M. L. , Van Craenenbroeck Kathleen , Van Calenbergh Serge 
Published: February 2018

AbstractCurrently, there is mounting evidence that intermolecular receptor–receptor interactions may result in altered receptor recognition, pharmacology and signaling. Heterobivalent ligands have been proven useful as molecular probes for confirming and targeting heteromeric receptors. This report describes the design and synthesis of novel heterobivalent ligands for dopamine D2‐like receptors (D2‐likeR) and the μ‐opioid receptor (μOR) and their evaluation using ligand binding and functional assays. Interestingly, we identified a potent bivalent ligand that contains a short 18‐atom linker and combines good potency with high efficacy both in β‐arrestin 2 recruitment for μOR and MAPK‐P for D4R. Furthermore, this compound was characterized by a biphasic competition binding curve for the D4R–μOR heterodimer, indicative of a bivalent binding mode. As this compound possibly bridges the D4R–μOR heterodimer, it could be used as a pharmacological tool to further investigate the interactions of D4R and μOR.
Decreased early mortality associated with the treatment of acute myeloid leukemia at National Cancer Institute‐designated cancer centers in California
Authors: Ho Gwendolyn , Wun Ted , Muffly Lori , Li Qian , Brunson Ann , Rosenberg Aaron S. , Jonas Brian A. , Keegan Theresa H.M. 
Published: February 2018

BACKGROUNDTo the authors' knowledge, few population‐based studies to date have evaluated the association between location of care, complications with induction therapy, and early mortality in patients with acute myeloid leukemia (AML).METHODSUsing linked data from the California Cancer Registry and Patient Discharge Dataset (1999‐2014), the authors identified adult (aged ≥18 years) patients with AML who received inpatient treatment within 30 days of diagnosis. A propensity score was created for treatment at a National Cancer Institute‐designated cancer center (NCI‐CC). Inverse probability‐weighted, multivariable logistic regression models were used to determine associations between location of care, complications, and early mortality (death ≤60 days from diagnosis).RESULTSOf the 7007 patients with AML, 1762 (25%) were treated at an NCI‐CC. Patients with AML who were treated at NCI‐CCs were more likely to be aged ≤65 years, live in higher socioeconomic status neighborhoods, have fewer comorbidities, and have public health insurance. Patients treated at NCI‐CCs had higher rates of renal failure (23% vs 20%; P = .010) and lower rates of respiratory failure (11% vs 14%; P = .003) and cardiac arrest (1% vs 2%; P = .014). After adjustment for baseline characteristics, treatment at an NCI‐CC was associated with lower early mortality (odds ratio, 0.46; 95% confidence interval, 0.38‐0.57). The impact of complications on early mortality did not differ by location of care except for higher early mortality noted among patients with respiratory failure treated at non‐NCI‐CCs.CONCLUSIONSThe initial treatment of adult patients with AML at NCI‐CCs is associated with a 53% reduction in the odds of early mortality compared with treatment at non‐NCI‐CCs. Lower early mortality may result from differences in hospital or provider experience and supportive care. Cancer 2018;124:1938‐45. © 2018 American Cancer Society.
Understanding Brønsted‐Acid Catalyzed Monomolecular Reactions of Alkanes in Zeolite Pores by Combining Insights from Experiment and Theory
Authors: Van der Mynsbrugge Jeroen , Janda Amber , Lin Li‐Chiang , Van Speybroeck Veronique , Head‐Gordon Martin , Bell Alexis T. 
Published: February 2018

AbstractThe front cover artwork is provided by Bell and co‐workers. The image shows a butane molecule adsorbed at a Brønsted acid site inside the pores of zeolite H‐MFI, surrounded by the products of monomolecular cracking and dehydrogenation reactions catalyzed by these sites. Read the full text of the Minireview at 10.1002/cphc.201701084.
Correcting for missing and irregular data in home‐range estimation
Authors: Fleming C. H. , Sheldon D. , Fagan W. F. , Leimgruber P. , Mueller T. , Nandintsetseg D. , Noonan M. J. , Olson K. A. , Setyawan E. , Sianipar A. , Calabrese J. M. 
Published: February 2018

AbstractHome‐range estimation is an important application of animal tracking data that is frequently complicated by autocorrelation, sampling irregularity, and small effective sample sizes. We introduce a novel, optimal weighting method that accounts for temporal sampling bias in autocorrelated tracking data. This method corrects for irregular and missing data, such that oversampled times are downweighted and undersampled times are upweighted to minimize error in the home‐range estimate. We also introduce computationally efficient algorithms that make this method feasible with large data sets. Generally speaking, there are three situations where weight optimization improves the accuracy of home‐range estimates: with marine data, where the sampling schedule is highly irregular, with duty cycled data, where the sampling schedule changes during the observation period, and when a small number of home‐range crossings are observed, making the beginning and end times more independent and informative than the intermediate times. Using both simulated data and empirical examples including reef manta ray, Mongolian gazelle, and African buffalo, optimal weighting is shown to reduce the error and increase the spatial resolution of home‐range estimates. With a conveniently packaged and computationally efficient software implementation, this method broadens the array of data sets with which accurate space‐use assessments can be made.
Network analysis: An innovative framework for understanding eating disorder psychopathology
Authors: Smith Kathryn E. , Crosby Ross D. , Wonderlich Stephen A. , Forbush Kelsie T. , Mason Tyler B. , Moessner Markus 
Published: February 2018

AbstractNetwork theory and analysis is an emerging approach in psychopathology research that has received increasing attention across fields of study. In contrast to medical models or latent variable approaches, network theory suggests that psychiatric syndromes result from systems of causal and reciprocal symptom relationships. Despite the promise of this approach to elucidate key mechanisms contributing to the development and maintenance of eating disorders (EDs), thus far, few applications of network analysis have been tested in ED samples. We first present an overview of network theory, review the existing findings in the ED literature, and discuss the limitations of this literature to date. In particular, the reliance on cross‐sectional designs, use of single‐item self‐reports of symptoms, and instability of results have raised concern about the inferences that can be made from network analyses. We outline several areas to address in future ED network analytic research, which include the use of prospective designs and adoption of multimodal assessment methods. Doing so will provide a clearer understanding of whether network analysis can enhance our current understanding of ED psychopathology and inform clinical interventions.
Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy
Authors: Lai Yi‐Chen , Li Na , Lawrence William , Wang Sufen , Levine Amber , Burchhardt Daniela M. , Pautler Robia G. , Valderrábano Miguel , Wehrens Xander H. , Anderson Anne E. 
Published: February 2018

SummaryObjectiveSympathetic predominance and ventricular repolarization abnormalities represent epilepsy‐associated cardiac alterations and may underlie seizure‐induced ventricular arrhythmias. Myocardial ion channel and electrical remodeling have been described early in epilepsy development and may contribute to ventricular repolarization abnormalities and excitability. Using the pilocarpine‐induced acquired epilepsy model we sought to examine whether altered myocardial ion channel levels and electrophysiological changes also occur in animals with long‐standing epilepsy.MethodsWe examined myocardial adrenergic receptor and ion channel protein levels of epileptic and age‐matched sham rats (9–20 months old) using western blotting. Cardiac electrical properties were examined using optical mapping ex vivo and electrophysiology in vivo. We investigated the propensity for ventricular tachycardia (VT) and the effects of β‐adrenergic blockade on ventricular electrical properties and excitability in vivo.ResultsIn animals with long‐standing epilepsy, we observed decreased myocardial voltage‐gated K+ channels Kv4.2 and Kv4.3, which are known to underlie early ventricular repolarization in rodents. Decreased β1 and increased α1A adrenergic receptor protein levels occurred in the myocardium of chronically epileptic animals consistent with elevated sympathetic tone. These animals exhibited many cardiac electrophysiological abnormalities, represented by longer QRS and corrected QT (QTc) intervals in vivo, slower conduction velocity ex vivo, and stimulation‐induced VT. Administration of a β‐adrenergic antagonist late in epilepsy was beneficial, as the therapy shortened the QTc interval and decreased stimulation‐induced VT.SignificanceOur findings demonstrate that myocardial ion channel remodeling and sympathetic predominance, risk factors for increased ventricular excitability and arrhythmias, persist in chronic epilepsy. The beneficial effects of β‐adrenergic antagonist treatment late in the course of epilepsy suggest that attenuating elevated sympathetic tone may represent a therapeutic target for ameliorating epilepsy‐associated cardiac morbidity.
Effect of Co‐Ni Ratio in Graphene Based Bimetallic Electro‐catalyst for Methanol Oxidation
Authors: Sarwar E. , Noor T. , Iqbal N. , Mehmood Y. , Ahmed S. , Mehek R. 
Published: February 2018

AbstractIn this paper the electro‐catalytic oxidation of methanol is studied on the non‐noble catalysts Ni–Co/graphene. The bimetallic electro‐catalyst was prepared with different Co–Ni ratios by using simple solution synthesis method. The synthesized materials were characterized by X‐ray diffraction (XRD) and scanning electron microscopy (SEM) for their structure and morphological changes. The electro‐catalytic activity of Ni–Co/graphene for methanol oxidation was investigated by cyclic voltammetry (CV) on glass carbon electrode (GCE) in alkaline medium with 1M methanol solution. The results of various electro‐catalysts have shown significant electro‐oxidation towards methanol. Increasing the Ni concentration in catalyst has promoted the oxidation reaction at the Co–Ni/graphene catalyst. This study reveals that the low‐cost electro‐catalyst Ni–Co/graphene has great potential for DMFC applications.
In vitro cytotoxicity assessment of nanodiamond particles and their osteogenic potential
Authors: Ibrahim Mohamed , Xue Ying , Ostermann Melanie , Sauter Alexander , Steinmueller‐Nethl Doris , Schweeberg Sarah , Krueger Anke , Cimpan Mihaela R. , Mustafa Kamal 
Published: February 2018

AbstractScaffolds functionalized with nanodiamond particles (nDP) hold great promise with regard to bone tissue formation in animal models. Degradation of the scaffolds over time may leave nDP within the tissues, raising concerns about possible long‐term unwanted effects. Human SaOS‐2 osteoblast‐like cells and U937 monoblastoid cells were exposed to five different concentrations (0.002–2 mg/L) of nDP (size range: 2.36–4.42 nm) for 24 h. Cell viability was assessed by impedance‐based methods. The differential expression of stress and toxicity‐related genes was evaluated by polymerase chain reaction (PCR) super‐array, while the expression of selected inflammatory and cell death markers was determined by reverse transcriptase quantitative polymerase chain reaction (RT‐qPCR). Furthermore, the expression of osteogenic genes by SaOS‐2 cells, alkaline phosphatase activity and the extracellular calcium nodule deposition in response to nDP were determined in vitro. Cells responded differently to higher nDP concentrations (≥0.02 mg/L), that is, no loss of viability for SaOS‐2 cells and significantly reduced viability for U937 cells. Gene expression showed significant upregulation of several cell death and inflammatory markers, among other toxicity reporter genes, indicating inflammatory and cytotoxic responses in U937 cells. Nanodiamond particles improved the osteogenicity of osteoblast‐like cells with no evident cytotoxicity. However, concentration‐dependent cytotoxic and inflammatory responses were seen in the U937 cells, negatively affecting osteogenicity in co‐cultures. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1697–1707, 2018.
Promotion of bone regeneration on titanium implants through a chemical treatment process using calcium phosphate slurry: Microscopic analysis, cellular response, and animal experiment
Authors: Ito Tatsuro , Ohtsu Naofumi , Tomozawa Masanari , Hirano Mitsuhiro , Takita Hiroko , Iizuka Tadashi , Yokoyama Atsuro 
Published: February 2018

AbstractThe present study provides scientific evidence that a new chemical treatment process using calcium phosphate slurry promotes bone regeneration on titanium (Ti) implants. The material's surface modified by the treatment was analyzed using microscopic observation and the bone regeneration efficacy was evaluated both in vitro and in vivo. Formation of a thin hydroxyapatite layer with a thickness of about 50 nm and an increase of surface roughness were confirmed by microscopic observations. Histological evaluation of rat femora implanted with the specimens showed that the areas of the specimens directly attached to bone tissue were significantly more extensive than those implanted with control Ti at 2 and 8 weeks. Likewise, on the treated Ti, ALP activity, osteopontin, osteocalcin, and calcium contents of rat bone marrow stromal cells were significantly higher than on the control Ti. Furthermore, reverse transcription polymerase chain reaction showed greater expression of messenger ribonucleic acid encoding Cbfa1 and collagen type1 on the treated Ti at 2 weeks. Based on these results, we concluded that the new process was effective to enhance the osteoconductivity of Ti. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2716–2724, 2018.