bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anxiety, depression, and headache‐related disability in a large pediatric clinic–based sample
Authors: Murphy Christina , Ladak Ali , Szperka Christina L. , Marquez De Prado Blanca , Hershey Andrew D. , Gentile Carlyn Patterson 
Published: November 2024

AbstractObjectiveTo explore the relationships among anxiety, depression, and headache‐related disability in a pediatric clinic–based retrospective cross‐sectional study.BackgroundAnxiety and depression are commonly considered comorbidities of headache disorders and are frequently seen in children and adolescents. These conditions can contribute to disability and may have a cumulative impact. In this study, we tested whether self‐reported anxiety and/or depression in youth were associated with headache‐related disability.MethodsThis was a retrospective cross‐sectional study of children ages 6–17 years old who completed a headache intake questionnaire at the time of a new outpatient neurology visit. Those who reported on behavioral health symptoms, involvement of a behavioral health provider (i.e., yes/no), and the PedMIDAS (a validated metric of headache‐related disability) were included. The relationship between anxiety and/or depression and headache‐related disability was examined.ResultsOf the 12,660 questionnaires queried, 9118 met criteria for inclusion. Respondents were 64.0% female and had a median age of 13.5 years (interquartile range [IQR] 10.3, 15.7). Compared to patients without self‐reported anxiety/depression, patients with anxiety and depression reported higher headache‐related disability (M = 17.0, [IQR 6.0, 41.0]) even after accounting for covariates (estimated difference = 6.0, 95% confidence interval [CI: 4.4–7.5]). For participants with anxiety and/or depression, having a behavioral health provider was associated with greater headache‐related disability (estimated difference = 7.0; 95% CI 4.6–9.3).ConclusionsPatients with self‐reported anxiety and/or depression reported higher headache‐related disability. Having a behavioral health provider was associated with greater headache‐related disability, indicating the complexity and high level of need for this population. Further research is needed to understand the directionality of these results; however, patients with headache as well as depression and or anxiety are a vulnerable group who may benefit from an integrated care model.
In vitro and patient studies with platelets to explore off‐target cardiovascular effects of integrase inhibitors
Authors: Keniyopoullos R. , Khawaja A. A. , Boffito M. , Emerson M. 
Published: November 2024

AbstractIntroductionPeople with HIV currently face a tenfold higher risk of developing cardiovascular disease (CVD) than those without HIV. Studies have shown various off‐target effects of antiretroviral treatment (ART) on the cardiovascular system, but little is known about the effects of currently used integrase strand transfer inhibitors (INSTIs) on platelets. Platelet activation is associated with increased CVD, thrombus formation, and release of proinflammatory mediators, so exploring platelet effects from currently prescribed ART may contribute to the understanding of CVD etiopathogenesis in people with HIV.MethodsWe aimed to identify potential effects of INSTIs on platelet aggregation and activation markers from individuals without HIV after in vitro treatment with clinically relevant drug concentrations. We used bictegravir (BIC) and dolutegravir (DTG) individually or in the therapeutic drug combinations BIC/emtricitabine (FTC)/tenofovir alafenamide fumarate (TAF) or DTG/lamivudine (3TC). Additionally, we conducted a pilot study to compare platelet activity profiles from people with HIV on BIC/FTC/TAF and DTG/3TC.ResultsChanges to in vitro platelet aggregation responses upon exposure to different INSTIs were observed both upon individual drug application and when using therapeutic combinations. However, these effects were not reflected in flow‐cytometric evaluation of platelet degranulation. A pilot study in eight people with HIV and eight without HIV revealed no significant effects but established protocols for future patient studies.ConclusionThere is currently no consistent evidence of an effect of INSTIs on platelet activation. Further study is warranted, focusing on models with more pathophysiological relevance, including extensive studies in people with HIV.
One name for two concepts: A systematic literature review about meta‐organizations
Authors: Coulombel Philippe , Berkowitz Héloïse 
Published: November 2024

AbstractExisting literature on meta‐organization is divided into two distinct streams in organizational and management studies, with different definitions and boundaries, potentially leading to inconsistencies and theoretical misalignment. Can we disambiguate the conceptualizations of meta‐organizations, and what insights can be gleaned from this clarification? Using a systematic review of the meta‐organization literature, we propose a novel classification, distinguishing between meta‐organizations as ‘meta‐level actors’, rooted in the organizational perspective, and meta‐organizations as ‘orchestrated systems’, grounded in the management perspective. While synthesizing current knowledge about meta‐organizations, we highlight the commonalities, divergences and specificities of both perspectives. We contribute to the literature on meta‐organizations by bringing greater clarity to the field, by disambiguating the uses of meta‐organization, by outlining a state of the art for both new categories and by providing a detailed research agenda. We also provide fundamental insights about two distinct ways of meta‐organizing, that is creating order among and beyond single organizations through collectively decided social orders and orchestrated social orders.
Pressureless sintering and properties of additively manufactured ZrB2–SiC
Authors: Lakusta Marharyta , Timme Nicholas M. , Watts Jeremy L. , Fahrenholtz William G. , Hilmas Gregory E. , Lipke David W. 
Published: November 2024

AbstractDensification behavior, grain growth kinetics, mechanical and thermal properties of pressurelessly sintered zirconium diboride–silicon carbide (ZrB2–SiC) fabricated by extrusion of high solids loading pastes have been studied. The effects of sintering temperature (1600–2300°C), heating rate during constant heating rate sintering (10–50°C/min), and time during isothermal sintering (3–24 h) on density and grain size were examined. The apparent activation energy for densification was determined to be 940 ± 90 kJ/mol, suggesting lattice diffusion as the dominant sintering mechanism. Grain growth of both ZrB2 and SiC followed a normal grain growth power law with grain growth exponent n = 2 indicating diffusion‐controlled coarsening. The activation energies for grain growth were 267 ± 10 kJ/mol for ZrB2 and 264 ± 15 kJ/mol for SiC. Sintered microstructures were homogeneous with relative densities of 95%–99% depending on heat treatment schedules. Flexural strength (270 ± 40 MPa) was lower than hot‐pressed materials of equivalent composition by a factor of two or more due to the presence of pores originating from paste inhomogeneities. Young's modulus (482 ± 20 GPa) and Vicker's microhardness (22 ± 5 MPa HV0.2), as well as thermal diffusivity and thermal conductivity up to 1800°C were found to be comparable to hot‐pressed materials.
The Effects of Wildfires on the Mental and Physical Health of School‐Age Children in North America: A Scoping Review
Authors: Oerther Sarah , Manspeaker Sarah , Wix Alison , Oerther Daniel , Marsit Carmen 
Published: November 2024

ABSTRACTBackgroundWildfires are occurring more often and with greater intensity, leading to longer and harsher fire seasons. As a result, children are more frequently exposed to wildfire smoke, which increases their risk of mental and physical health effects.PurposeThe purpose of our scoping review is to explore the current literature on what is known about the direct and indirect impacts of wildfires on the mental and physical health of school‐age children in North America (5 to 18‐year‐olds).MethodsA health sciences librarian‐assisted literature search, with input from the research team, was performed.ResultsA total of 16 studies were selected. Common mental health symptoms such as anxiety, depression, suicidal thinking, and post‐traumatic stress disorder have been identified. The findings of this review are in line with recent studies showing a connection between adult wildfire exposure and respiratory conditions; however, no cardiovascular health effects in children were identified.ConclusionsThe available studies in our review demonstrate that wildfires do increase the impacts on both mental and physical health postexposure in school‐age children. Future research should specifically include larger samples, more qualitative and longitudinal studies that can more effectively analyze the effects of wildfire events on psychological factors over time, conceptual frameworks, and exposure metrics specific for PM2.5 from wildfire smoke.
Correlations of the Circadian Rhythmicity of Blood Pressure With Erectile Dysfunction
Authors: Koçak Ajar , Şenol Cem , Yıldırım Onur , Arıkan Ergün Bilgesu 
Published: November 2024

ABSTRACTErectile dysfunction (ED) and cardiovascular diseases (CVD) share common pathophysiological mechanisms. This study aimed to assess the relationship between ED and its severity with the risk of developing CVD by analyzing changes in the circadian blood pressure (BP) rhythm. In the study, 24‐h BP levels of 192 (94 with ED and 98 controls) participants with no history of CVD were evaluated using an ambulatory blood pressure monitoring (ABPM) device. The International Index of Erectile Function (IIEF) questionnaire was used to assess the ED severity in the study group. ABPM measurements revealed higher BP values among the ED group. The nondipper pattern was significantly more frequent in the ED group compared to the controls (56.2% vs. 77.1%, p < 0.01). Blood pressure variability parameters, including systolic standard deviation (SD) and average real variability (ARV), were notably higher in the ED group (16.3 ± 3.9 vs. 14.6 ± 4.3, p < 0.01 and 13.39 ± 7.24 vs. 11.5 ± 2.1, p < 0.01, respectively). Furthermore, parameters reflecting arterial stiffness including pulse pressure index (PPI) and ambulatory arterial stiffness index (AASI) were higher in the ED group (0.81 ± 0.33 vs. 0.73 ± 0.18, p = 0.03 and 0.71 ± 0.09 vs. 0.59 ± 0.17, p = 0.014, respectively). Both AASI and ARV were significantly correlated with the severity of ED. This study suggests a significant association between ED severity and altered blood pressure patterns which in part explains the increased risk of CVD among individuals with ED.
Simulation Study on the Optimization of Temperature Cable Layout in a Warehouse During the Ventilation
Authors: Yang Kaimin , Chu Fengjiao , Wang Yuancheng , Dong Xiaoqian 
Published: November 2024

ABSTRACTThe temperature data obtained from cables monitoring stored grain are crucial for real‐time surveillance of grain storage and serve as a reference for processes such as ventilation. This study focuses on optimizing the arrangement of temperature cables within the warehouse and employing numerical simulations to analyze the variation in grain temperature during a 7‐day cooling ventilation period. By comparing the predicted average temperature of bulk grain with the temperatures recorded by cable sensors, the study evaluates the potential benefits and cost implications of various cable layouts. The maximum difference in the average temperature between the monitoring temperature by cables and the predicted temperature in bulk grain was 0.70°C, and the root mean square error (RMSE) was 25.83% when the cables were arranged according to the national standard (National Standard of P.R. China, GB/T 26882.1‐2011). The study further examines the impact of optimizing cable layout, including variations in horizontal spacing, on the RMSE. It was found that reducing cable spacing decreased the RMSE but necessitated an increased number of cables. Conversely, increasing cable spacing led to a decrease in the number of cables but resulted in a higher RMSE. Based on an optimized non‐uniform layout with the less cables, which were inserted with dense cables near the wall and sparse cables in bulk grain, it was found that the RMSE was reduced to 22.23%, and the number of the cables was reduced by four cables compared to the national standard layout. The non‐uniform layout was also verified for applicability in large‐scale warehouses, showing a reduction of 26 cables compared to the national standard. The results demonstrated that the current cable layout of the national standard needs optimization, and that the optimization direction of the uniform layout does not guarantee economy and accuracy at the same time during the monitoring temperature in bulk grain. The non‐uniform cable layout, with fewer cables and improved monitoring accuracy, presents a promising approach for practical application.
Automatic localization and deep convolutional generative adversarial network‐based classification of focal liver lesions in computed tomography images: A preliminary study
Authors: Gupta Pushpanjali , Hsu Yao‐Chun , Liang Li‐Lin , Chu Yuan‐Chia , Chu Chia‐Sheng , Wu Jaw‐Liang , Chen Jian‐An , Tseng Wei‐Hsiu , Yang Ya‐Ching , Lee Teng‐Yu , Hung Che‐Lun , Wu Chun‐Ying 
Published: November 2024

AbstractBackground and AimComputed tomography of the abdomen exhibits subtle and complex features of liver lesions, subjectively interpreted by physicians. We developed a deep learning‐based localization and classification (DLLC) system for focal liver lesions (FLLs) in computed tomography imaging that could assist physicians in more robust clinical decision‐making.MethodsWe conducted a retrospective study (approval no. EMRP‐109‐058) on 1589 patients with 17 335 slices with 3195 FLLs using data from January 2004 to December 2020. The training set included 1272 patients (male: 776, mean age 62 ± 10.9), and the test set included 317 patients (male: 228, mean age 57 ± 11.8). The slices were annotated by annotators with different experience levels, and the DLLC system was developed using generative adversarial networks for data augmentation. A comparative analysis was performed for the DLLC system versus physicians using external data.ResultsOur DLLC system demonstrated mean average precision at 0.81 for localization. The system's overall accuracy for multiclass classifications was 0.97 (95% confidence interval [CI]: 0.95–0.99). Considering FLLs ≤ 3 cm, the system achieved an accuracy of 0.83 (95% CI: 0.68–0.98), and for size > 3 cm, the accuracy was 0.87 (95% CI: 0.77–0.97) for localization. Furthermore, during classification, the accuracy was 0.95 (95% CI: 0.92–0.98) for FLLs ≤ 3 cm and 0.97 (95% CI: 0.94–1.00) for FLLs > 3 cm.ConclusionThis system can provide an accurate and non‐invasive method for diagnosing liver conditions, making it a valuable tool for hepatologists and radiologists.
Novel analysis tool for the distance of gold dimers controlled by the DNA strand length on the DNA origami
Authors: Guckel Jannik , Liu Zhe , Wang Zunhao , Lalkens Birka , Etzkorn Markus , Park Daesung 
Published: November 2024

AbstractMetallic nanoparticle dimers have been used to enhance the excitation rate of single‐quantum emitters. The interparticle distance (d) of the dimers has a crucial influence on the signal enhancement. Therefore, precise control of d is desired for optimal performance. However, statistical analysis of d has been often restricted to a small number of dimers due to the lack of reliable automatic software tools.For this reason, we developed a novel analysis tool for automatic dimer analysis. Our approach combines particle detection by circle Hough transformation (CHT) with custom classification routines optimised for distinct types of particles. We applied our tool to scanning electron microscopy (SEM) images and achieved great agreement in dimer detection, reaching an agreement of around 97% between automatic analysis and manual inspection for more than 3000 metallic nanoparticle dimers on DNA origami controlled by a combination of multiple DNA strands.Our study revealed the effects of the strand length (L) on the distribution of d. Based on geometric consideration, we expected a strong correlation between L and the standard deviation (σ) of d. We could verify this correlation by characterising four dimer designs with different L while analysing more than 1000 dimers per specimen.
Taking a social‐class‐in‐context perspective on the psychology of social class
Authors: Stephens Nicole M. , Emery Lydia F. , Townsend Sarah S. M. , Song Hannah J. 
Published: November 2024

AbstractSocial class researchers in social psychology have pushed the field to become more focused on and attentive to the critical role of sociocultural contexts. In this article, we label and articulate the key ingredients of the approach that many social psychological researchers have come to use: what we refer to as a social‐class‐in‐context perspective. This perspective means attending to the contextual differences in resources that create social class differences in psychology and behavior. We also suggest some additional steps that researchers can take to become even more attentive to and responsive to the important role of contexts in creating social class. As a first step, we suggest the importance of adopting a definition of social class that directly explicates its relationship to similar constructs, such as power and status, and also links it to the contexts that produce it. Second, building on this definition of social class, we then describe the importance of taking a multi‐level approach to understanding how different social class contexts shape psychology and behavior. Finally, we articulate the important implications and future directions that emerge from intentionally adopting this perspective.
Preferences and Feasibility of Long‐Acting Technologies for the Treatment of Hepatitis C Virus: A Survey of Patients in Diverse Low‐ and Middle‐Income Countries
Authors: Furl Renae , Scarsi Kimberly K. , Sayles Harlan , Anderson Matt , Ofimboudem Joelle Dountio , Weld Ethel D. , Waked Imam , Gomaa Asmaa , Al‐Khatib Alzhraa , Elshobary Fatma Mohammed , Desalegn Hailemichael , Fisseha Henok , Solomon Sunil , Mehta Shruti , Owen Andrew , Rannard Steve , Thomas David L. , Swindells Susan 
Published: November 2024

ABSTRACTDespite available curative treatments, global rates of hepatitis C virus (HCV) infection persist with significant burden in low‐ and middle‐income countries (LMICs). Long‐acting (LA) antiviral products are in development. This study explored the challenges and opportunities in LA‐HCV treatment across three LMICs: Egypt, Ethiopia and India. The survey focused on understanding barriers and facilitators to treatment, with emphasis on LA treatment preferences. Four‐hundred respondents completed a survey including demographics, HCV treatment history and preferences for injections, implants and microarray patches (MAPs) compared to pills. Overall, 78% of respondents were willing to receive injections, 43% were willing to receive implants and 55% were willing to receive MAPs. Marked heterogeneity in acceptability of non‐oral treatments was observed. Among respondents who had not previously received HCV treatment, 94%, 43%, and 75% were willing to receive injections, implants, or MAPs, respectively. In contrast, among those already cured by oral HCV treatment, 61%, 40% and 43% were willing to receive injections, implants or MAPs. Other characteristics associated with willingness to receive an injection included urban residence, younger age, male sex, higher education level and taking pills for any reason (all results p < 0.001). The most common concern for all LA modalities was lack of effectiveness. Prior experience with injection or implant increased willingness to receive any LA modality (p < 0.001). Coupled with a point‐of‐care HCV diagnostic test, availability of and willingness to receive HCV treatment delivered by a LA formulation could simplify and expand treatment access in LMICs and contribute towards global HCV elimination goals.
Microglial activation without peripheral immune cell infiltration characterises mouse and human cerebral small vessel disease
Authors: Deshpande Tushar , Hannocks Melanie‐Jane , Kapupara Kishan , Samawar Sai Kiran Reddy , Wachsmuth Lydia , Faber Cornelius , Smith Colin , Wardlaw Joanna , Sorokin Lydia 
Published: November 2024

AbstractAimsCerebral small vessel diseases (SVDs) involve diverse pathologies of the brain's small blood vessels, leading to cognitive deficits. Cerebral magnetic resonance imaging (MRI) reveals white matter hyperintensities (WMHs), lacunes, microbleeds and enlarged perivascular spaces in SVD patients. Although correlations of MRI and histopathology help to understand the pathogenesis of SVD, they do not explain disease progression. Mouse models, both genetic and sporadic, are valuable for studying SVD, but their resemblance to clinical SVD is unclear. The study examined similarities and differences between mouse models of SVDs and human nonamyloid SVD specimens.MethodsWe analysed four mouse models of SVD (hypertensive BPH mice, Col4a1 mutants, Notch3 mutants and Htra1−/− mice) at different stages for changes in myelin, blood‐brain barrier (BBB) markers, immune cell populations and immune activation. The observations from mouse models were compared with human SVD specimens from different regions, including the periventricular, frontal, central and occipital white matter. Postmortem MRI followed by MBP immunostaining was used to identify white matter lesions (WMLs).ResultsOnly Notch3 mutant and hypertensive BPH mice showed significant changes in myelin basic protein (MBP) immunostaining, correlating with MRI patterns. These changes were linked to altered microglial morphology and focal plasma protein staining around blood vessels, without peripheral immune cell infiltration. In human specimens, both normal‐appearing white matter (NAWM) and WMLs lacked peripheral cell infiltration. However, WMLs displayed altered microglial morphology, reduced myelin staining and occasional fibrinogen staining around arterioles and venules.ConclusionsOur data show that Notch3 mutants and hypertensive BPH/2J mice recapitulate several features of human SVD, including microglial activation, focal sites of demyelination and perivascular plasma protein leakage without peripheral immune cell infiltration.
Unravelling the different components of nonphotochemical quenching using a novel analytical pipeline
Authors: Ramakers Lennart A. I. , Harbinson Jeremy , Wientjes Emilie , van Amerongen Herbert 
Published: November 2024

Summary
Photoprotection in plants includes processes collectively known as nonphotochemical quenching (NPQ), which quench excess excitation‐energy in photosystem II. NPQ is triggered by acidification of the thylakoid lumen, which leads to PsbS‐protein protonation and violaxanthin de‐epoxidase activation, resulting in zeaxanthin accumulation. Despite extensive study, questions persist about the mechanisms of NPQ.
We have set up a novel analytical pipeline to disentangle NPQ induction curves measured at many light intensities into a limited number of different kinetic components. To validate the method, we applied it to Chl‐fluorescence measurements, which utilised the saturating‐pulse methodology, on wild‐type (wt) and zeaxanthin‐lacking (npq1) Arabidopsis thaliana plants. NPQ induction curves in wt and npq1 can be explained by four components (, , and ).
The fastest two ( and ) correlate with pH difference formed across the thylakoid membrane in wt and npq1. In wt, the slower component () appears to be due to the formation of zeaxanthin‐related quenching whilst for npq1, this component is ‘replaced’ by a slower component (), which reflects a photoinhibition‐like process that appears in the absence of zeaxanthin‐induced quenching.
Expanding this approach will allow the effects of mutations and other abiotic‐stress factors to be directly probed by changes in these underlying components.