bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of eating behavior of children of different age groups
Authors: Girsh Ya. V. , Yuditskaya T. A. 
Published: July 2018

The phenomenon of eating behavior in the development of obesity in the pediatric age group remains poorly understood.The purpose of the study. To determine the peculiarities of eating behavior of children of various age groups depending on body mass.Material and methods. A comparative prospective study of 905 children: 342 children 1–7 years (4.7 ± 1.29), 249 children aged 8–12 (11.08 ± 0.81) and 314 adolescents 13–18 (14.25 ± 1,34). A physical survey was conducted according to standard methods with calculation of body mass index. For the study of eating behavior of preschool children, a survey of the parents was conducted using the scales of CEBQ (Child Eating Behaviour Questionnaire; J. Wardle, 2001; by the license author), an assessment of eating behavior of children 8–12 years was conducted through the analysis of the questionnaire FEV - II, and an assessment of adolescents was done with the use of the Dutch questionnaire DEBQ (Dutch Eating Behavior Questionnaire). Statistical analysis: STATISTICA (version 8), Microsoft Excel 7,0.Results. Assessment of the frequency of occurrence of eating disorders in children and adolescents showed that regardless of age and body mass, all the children had eating disorders. The development of pathological disorders begins at 5-years of age and acquires a clear shape at 7 years. All children with normal body weight was dominated by external type of eating behavior, in subgroups of patients with overweight / obesity was the prevalent restrictive type. In patients with obesity, a third had combined forms of food behavior with the prevalence of the combination in children 8–12 years of restrictive and external types, in children 13–18 years of restrictive and emotional types. The frequency of occurrence of these combinations was increased together with the increase in children of body weight.
Risk factors associated with the development of undifferentiated connective tissue dysplasia
Authors: Kalaeva G. Yu. , Khokhlova O. I. , Deev I. A. , Мikheenko G. A. 
Published: July 2018

Development of the undifferentiated connective tissue dysplasia (UCTD) is influenced by various adverse factors to the fetus during intrauterine growth. There is not a clear linkage to the contribution of the separate factors to the development of the UCTD.Aims of the studyare to determine the risk factors associated with the development of the UCTD of the adolescents and to appreciate the predictive value of the examined factors related to UCTD to form the dispensary groups of the children with UCTD.Materials and methods. During the first stage of the study there was an examination of 110 adolescents at the age of 10–14 years old, the UCTD presence was established according to the scale proposed by T.I. Kadurina and V.N. Gorbunova (2009). During the second stage the data of the prenatal casework and maternity hospital records attached to the out-patient medical records were examined to detect the specialties of the antenatal life course. During the third stage 2 groups were formed: with the presence of UCTD (n = 81) and without UCTD (n = 29). The mother groups were formed accordingly with the adolescents groups.Results. The pregnancy of the mothers of the adolescents with UCTD proceeded against the anemia, threatening miscarriage, chronic fetal hypoxia, chronic fetoplacental insufficiency, toxicosis, gestosis, and concomitant chronic conditions (thyroid, kidneys, digestive apparatus, aspiration pathology) more common than the pregnancy of the mothers of the adolescents without UCTD. The binary logistic regression method allowed the predictors of the UCTD’s formation to be determined, there were: toxicosis during the gestation course (OR = 10.9; CI 95% 2.94–40.49), anemia of pregnancy (OR = 8.6; CI 95%: 2.42–30.81), gestosis (OR = 6.53; CI 95%: 1.27–33.71), chronic fetal hypoxia (OR = 4.4; CI 95%: 1.09–17.83) and pre-existing chronic conditions of the mothers (OR = 3.6; CI 95%: 0.86–15.48). Different factor combination enhances the likelihood of the delivery of a child with UCTD more than 6.5-fold: chronic conditions of the mothers and chronic fetal hypoxia (OR = 6.8; CI 95%: 1.95–48.57); anemia of pregnancy and chronic fetal hypoxia (OR = 7.2; CI 95%: 1.01–50.99), and toxicosis (OR = 10.4; CI 95%: 1.48–72.82).Conclusion. The risk factors associated to the development of UCTD in adolescents are: toxicosis during the gestation course, anemia of pregnancy, gestosis, chronic fetal hypoxia and pre-existing chronic conditions of the mothers. The use of the equation of the binary logistic regression allows the prediction of the possibility of the development of UCTD in adolescents at the level of 80.9% and to form the dispensary groups of children in order to prevent the development of dysplastic-dependent pathology
Evaluation of the influence of clinical risk factors on the performance of extracorporal fertilization programs
Authors: Likhacheva V. V. , Markdorf A. G. , Bazhenova L. G. , Vlasenko A. E. , Shramko S. V. 
Published: July 2018

Purpose of the study. To assess the influence of main clinical risk factors on the effectiveness of the in vitro fertilization (IVF) program.Materials and methods. The study included 3,969 IVF programs conducted in the “Medica” clinic of the “Mother and Child” group of companies in Novokuznetsk for 2010–2015. The inclusion criterion was the availability of information on the results of the procedure conducted.Results.The structure of the considered risk factors was identified, their key features were identified: the majority of women who underwent IVF procedure were under the age of 34, inclusive, more than half of all procedures were performed at the first attempt. The main causes of female infertility were: tubal factor, including those associated with chronic endometritis, polycystic ovary syndrome, external genital endometriosis and adenomyosis. In a number of cases, as a concomitant gynecological disease, uterine fibroids have been extirpated, which is not the main cause of infertility, but the presence of which can influence the effectiveness of IVF programs. Statistically significantly more often, fibroids were found in adenomyosis and tubal factors associated with chronic endometritis. A quantitative assessment of the degree of influence of the considered risk factors on the effectiveness of IVF programs was considered, and the influence of both individual factors and their combination was considered.Conclusion.The main factors statistically significantly increasing the risk of a negative outcome of the program are: the age of a woman over 30; repeated attempt at the age of up to 30 years inclusive (in comparison with the first attempt); tubular factor associated with chronic endometritis; presence of uterine fibroids in the tubular factor associated with chronic endometritis; The presence of fibroids in the tubular factor, complicated by adenomyosis.
Influence of L-tryptophan use on the dynamics of cognitive functions in the complex therapy of delayed psycho-speech development in children
Authors: Polyakov V. M. , Rychkova L. V. , Belogorova T. A. , Mikhnovich V. I. , Bugun O. V. , Berdina O. N. , Prokhorova Zh. V. , Teterina T. A. , Lebedeva L. N. , Lebedeva L. I. 
Published: July 2018

The purpose of this studyis to evaluate the ability of L-tryptophan used in complex therapy of delayed psycho-speech development in children to influence the dynamics of cognitive performance.Materials and methods. The study included 80 children aged 3–7 years with delayed psycho-speech development (DPSD). The main group consisted of 37 children (25 male and 12 female), a control group – 43 patients (30 male and 13 female). Both groups of children were comparable in age, sex, degree of speech and cognitive impairment, and IQ level. Patients in the main group have taken standard therapy with L-tryptophan (25–50 mg per day depending on the age) supplement for 14 days. Control patients have taken standard therapy only. Psychodiagnostic tests at the entrance and exit of patients from this study was carried out for evaluation the dynamics of cognitive functions. All differences were considered significant at p < 0.05.Results. The study suggests that oral L-tryptophan intake selectively affects the dynamics of cognitive performance in children with DPSD. So, we studied pre- and post-treatment cognitive performance in both group patients and noted a significant improvement in the visual memory (p < 0.001) and an increase in thinking productivity (p < 0.001) in the tryptophan group versus similar indicators in the control group. Intergroup differences (p < 0.001 and p = 0.026, respectively, for the main and control groups) also found.Conclusion. Two-week L-tryptophan intake in complex therapy of DPSD in children can significantly improve the cognitive activity, and greatly increase both the effectiveness and sustainability of treatment outcomes, which will significantly reduce the time and frequency of hospitalization and financial costs for the rehabilitation of this patients.
E-cigarettes in airports and on flights: Europe and the US
Authors: López Medina Mª José , Continente Xavier , Soong Andrea , Stillman Frances , Zheng Laura , Garcia-Esquinas Esther , Pang Yuanjie , Navas-Acien Ana 
Published: July 2018

Background. While progress has been made to create smoke-free airports, sales of e-cigarettes at airports and airplanes and the presence of advertisements might detract from these smoke-free policies. The objective of this study is to describe the presence of policies, advertising, sales and use of e-cigarettes in airports and on flights in Europe and the US.Methods. A cross-sectional study was conducted between March-May, 2014. The study included 21 large and mid-sized airports of Europe and the US as well as 19 flights. A standardised protocol was used to observe points of sales and advertisements and to collect information on the implementation of policies on e-cigarette use. In addition, a series of questions were developed to obtain policy details from airport personnel and flight attendants.Results. Retail outlets selling e-cigarettes in airports were present in approximately 20% and 40% of the observed pre and post-security areas, respectively. In post-security, 27.8% of the airport staff reported that the use of e-cigarettes indoors was not allowed, 22.2% reported that they did not know, 27.8% reported that it was only allowed in the smoking room, and 22.2% reported that it was allowed anywhere. Smoking ban announcements were made on all flights. However, only 15.8% of the flights made a specific announcement regarding the ban of using e-cigarettes. Conclusions. In light of our results, it seems necessary to reinforce in-flight e-cigarette smoking ban announcements and to instruct airport employees about the existence of e-cigarette smoking policies. Furthermore, airports themselves should also be encouraged to adopt smoke-free policies.
Exploring the direct or inverse association of physical activity with behavioral addictions and other self-regulation problems
Authors: Cardol Cinderella K. , Escamilla Cristopher I. , Gebhardt Winifred A. , Perales José C. 
Published: July 2018

This cross-sectional survey study had the aim of clarifying the relationships between leisure time physical activity (LTPA) and non-drug-re­lated self-regulation problems (non-drug-related SRPs), including behavioral addictions, and the role of impulsive personality traits therein. Spanish university students (N = 329; Mage = 21.20) completed questionnaires for each of these constructs. Fitness and Bodybuilding LTPA was negatively associated with video gaming-related SRPs, r = -.13, p = .019, 95% CI (bootstrapped) [-.23, -.02], and positively associated with sex-related SRPs, r = .16, p = .005, 95% CI (bootstrapped) [.04, .30]. Endurance LTPA was associated with higher scores in eating-related SRPs, r = .17, p = .003, 95% CI (bootstrapped) [.02, .31]. The proportion of participants presenting scores above the clinically significant threshold in eating-related SRPs was 2.64 times higher for respondents in an Excessive Endurance LTPA cluster compared to the other respondents, Fisher’s exact test, p = .017, OR = 3.10, 95% CI [1.26, 7.63], and the proportion of participants reporting vomiting to control weight was 2.12 times higher, Fisher’s exact test, p = .040, OR = 2.43, 95% CI [1.06, 5.57]. The associations were largely independent of impulsive personality traits. We identified an elevated risk of eating pathology in a subgroup of participants with anomalously high participation in endurance physical activity. This overlap is consistent with the secondary dependence hypothesis of exercise addiction.
EVALUATION INFORMATION TECHNOLOGY UTILIZATION OF SCHOOL SUBJECT SCHEDULING USING PIECES FRAMEWORK
Authors: Thenata Angelina Pramana , Prabawati Andhika Galuh 
Published: July 2018

Abstract— Information technology has been widely used by several aspects, such as in the scope of business, industry, government, education, and service. The use of information technology in various aspects of spatial planning can help in its business process. One of the use of information technology in the field of education is e-learning, scheduling, financial information systems, and others. SMK N 1 Kaliwungu is one of the schools that already utilize information technology, such as Program Scheduling Subject Schedule. The program helps scheduling in its implementation need to be evaluated to improve more accurate objectives. In this study, will be discussed about system scheduling program Lesson using PIECES Framework. The Framework section is one way of ordering systems or applications related to Performance, Information, Economics, Control, Efficiency, Application Services. Theuse of this framework aims to determine theimplementation of scheduling aids program at SMKN1 Kaliwungu works as a support, enabler, ordriver in the utilization of Information Technology. This research using data from interviews,observations on the curriculum and provision ofquestionnaires to 30 teachers SMKN 1 Kaliwungu. The result of the evaluation obtained from this research is the utilization of scheduling aidsprogram can improve the curriculum performance program can improve the curriculum performance and teaching process to be smoothly without anycollision schedule. The results of evaluation in this research can be said that the utilization of auxiliary programscheduling at SMKN 1 Kaliwungu role as an enabler.
Keyword ----- Evaluation, Technology Information, PIECESFramework, Schedulling
QSAR Studies of Halogenated Pyrimidine Derivatives as Inhibitors of Human Dihydroorotate Dehydrogenase Using Modified Bee Algorithm
Authors: Atabati Hossein , Zarei Kobra , Zare-Mehrjardi Hamid Reza 
Published: July 2018

Aim and Objective:
Human dihydroorotate dehydrogenase (DHODH) catalyzes the fourth
stage of the biosynthesis of pyrimidines in cells. Hence it is important to identify suitable inhibitors
of DHODH to prevent virus replication. In this study, a quantitative structure-activity relationship
was performed to predict the activity of one group of newly synthesized halogenated pyrimidine
derivatives as inhibitors of DHODH.

Materials and Methods:
Molecular structures of halogenated pyrimidine derivatives were drawn in
the HyperChem and then molecular descriptors were calculated by DRAGON software. Finally, the
most effective descriptors for 32 halogenated pyrimidine derivatives were selected using bee
algorithm.

Results:
The selected descriptors using bee algorithm were applied for modeling. The mean relative
error and correlation coefficient were obtained as 2.86% and 0.9627, respectively, while these
amounts for the leave one out−cross validation method were calculated as 4.18% and 0.9297,
respectively. The external validation was also conducted using two training and test sets. The
correlation coefficients for the training and test sets were obtained as 0.9596 and 0.9185,
respectively.

Conclusion:
The results of modeling of present work showed that bee algorithm has good
performance for variable selection in QSAR studies and its results were better than the constructed
model with the selected descriptors using the genetic algorithm method.
Double C–H Activation for the C–C bond Formation Reactions
Authors: Liu Jialin , Xiong Xiaoyu , Chen Jie , Wang Yuntao , Zhu Ranran , Huang Jianhui 
Published: July 2018

Background:
Among the numerous bond-forming patterns, C–C bond formation is one of the most
useful tools for building molecules for the chemical industry as well as life sciences. Recently, one of the most
challenging topics is the study of the direct coupling reactions via multiple C–H bond cleavage/activation
processes. A number of excellent reviews on modern C–H direct functionalization have been reported by
Bergman, Bercaw, Yu and others in recent years. Among the large number of available methodologies, Pdcatalyzed
reactions and hypervalent iodine reagent mediated reactions represent the most popular metal and
non-metal involved transformations. However, the comprehensive summary of the comparison of metal and
non-metal mediated transformations is still not available.

Objective:
The review focuses on comparing these two types of reactions (Pd-catalyzed reactions and
hypervalent iodine reagent mediated reactions) based on the ways of forming new C–C bonds, as well as the
scope and limitations on the demonstration of their synthetic applications.

Conclusion:
Comparing the Pd-catalyzed strategies and hypervalent iodine reagent mediated methodologies
for the direct C–C bond formation from activation of C-H bonds, we clearly noticed that both strategies are
powerful tools for directly obtaining the corresponding pruducts. On one hand, the hypervalent iodine reagents
mediated reactions are normally under mild conditions and give the molecular diversity without the presence
of transition-metal, while the Pd-catalyzed approaches have a broader scope for the wide synthetic applications.
On the other hand, unlike Pd-catalyzed C-C bond formation reactions, the study towards hypervalent
iodine reagent mediated methodology mainly focused on the stoichiometric amount of hypervalent iodine reagent,
while few catalytic reactions have been reported. Meanwhile, hypervalent iodine strategy has been
proved to be more efficient in intramolecular medium-ring construction, while there are less successful examples
on C(sp3)–C(sp3) bond formation. In summary, we have demonstrated a number of selected approaches for
the formation of a new C–C bond under the utilization of Pd-catalyzed reaction conditions or hyperiodine reagents.
The direct activations of sp2 or sp3 hybridized C–H bonds are believed to be important strategies for the
future molecular design as well as useful chemical entity synthesis.
Serum Interleukin Levels and Insulin Resistance in Major Depressive Disorder
Authors: Al-Hakeim Hussein Kadhem , Al-Kufi Sadiq Neama , Al-Dujaili Arafat Hussein , Maes Michael 
Published: July 2018

Background & Objective: Major depressive disorder (MDD) has been associated with inflammatory
processes, including increased cytokine levels, even in individuals who are otherwise
physically healthy, while some MDD patients may show insulin resistance (IR).

Method:
However, correlations between cytokines and IR parameters have not been studied extensively
in MDD. In the present study, we measured IL-1β, IL-4, IFN-γ, TGF-β1, insulin and glucose in
63 MDD patients and 27 healthy controls. The associations between cytokine levels and IR were examined.

Results:
The results revealed a significant increase (p<0.05) in serum levels of IL-1β, IL-4, IFN-γ,
TGF-β1, insulin, insulin/glucose ratio, and insulin resistance (HOMA2IR) in MDD patients as compared
with controls. There was a significant correlation between HOMA2IR with both IFN-γ
(ρ=0.289, p<0.05) and TGF-β1 (ρ=0.364, p<0.05).

Conclusion:
The present study further confirms that MDD is accompanied by activation of the immune
system with significant elevations in the levels of four cytokines. These results indicate stimulation of the
immune system and increased IR and modulation of IR by increased cytokine levels in MDD. These
findings show that immune activation and associated IR are a new drug target in depression.
Quality of Life in People with Coeliac Disease: Psychological and Socio- Economic Aspects
Authors: Martínez-Martinez Maria Isabel , Alegre-Martínez Antoni , García-Ibánez Jessica , Cauli Omar 
Published: July 2018

Background and Objective: Coeliac disease (CD) is a chronic autoimmune intestinal disorder
characterized by intolerance to gluten, a protein contained in certain cereals. The main physiopathological
basis of CD is the progressive destruction of intestinal villi caused by gluten ingestion by
genetically-susceptible individuals. Patients who receive a diagnosis of CD must make significant
changes to their daily habits and this can affect their quality of life. The objective of this review is to
summarize the evidence regarding the economic, physical and social limitations which can affect the
quality of life in patients with CD.

Results:
Different factors such as physical changes, psychological effects, interpersonal relationships,
emotions and economic difficulties can affect the quality of life of these patients. Observations suggest
that, in general, women with CD experience a greater deterioration in their quality of life than men.
Lastly, complications in daily life are also associated with the reduced availability of gluten-free products
which also usually cost more than standard products.
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Conclusions: Continuous health education and care regarding socio-economic issues should be continuously
developed and provided to people with CD.
Fidelidad de localización en trayectorias de sonido envolvente acusmático versus visualizado
Authors: Luna Fabian Esteban 
Published: July 2018

El experimento buscó medir y comparar el grado de precisión que los participantes ponen en práctica para identificar trayectorias de fuentes de emisión sonora envolventes experimentadas de un modo acusmático y audiovisualizado. El trabajo se inscribe en el campo de estudios sobre la transmodalidad. En particular respecto de aquellas investigaciones que se han enfocado en las correspondencias entre la escucha y la visualización. En este contexto desarrollamos una plataforma de reproducción en música acusmática (Luna, 2015; 2016) con el fin de propiciar una modalidad alternativa de presentación en concierto para este tipo de obras (Prager, 2012; Truax, 1999; Tutschku, 2001). La propuesta combina los campos de difusión envolvente de sonido (surround), como así también de emisiones de luces (lightrround), en sincronía con la propagación de modos vibratorios (sensurround) dirigidos también a la audiencia.