bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a Highly Specific Biomarker for Germ Cell Malignancies: Plasma miR371 Expression Across the Germ Cell Malignancy Spectrum
Authors: Nappi Lucia , Thi Marisa , Lum Amy , Huntsman David , Eigl Bernie J. , Martin Christopher , O’Neil Brock , Maughan Benjamin L. , Chi Kim , So Alan , Black Peter C. , Gleave Martin , Wyatt Alex W. , Lavoie Jean Michel , Khalaf Daniel , Bell Robert , Daneshmand Siamak , Hamilton Robert J. , Leao Ricardo R.N. , Nichols Craig , Kollmannsberger Christian 
Published: September 2019

PURPOSE Our objective was to evaluate operating characteristics, particularly specificity and positive predictive value (PPV), by mapping plasma miR371 expression to actual clinical events in patients with a history of germ cell tumor. PATIENTS AND METHODS One hundred eleven male patients with a history of or newly diagnosed germ cell tumors were evaluable. Biospecimens obtained before confirmed clinical events were analyzed for miR371 expression with blinding of providers and laboratory personnel to analytic results or clinical status, respectively. Cases (patients with clinically confirmed active germ cell malignancy [aGCM]) and controls (patients with no clinically confirmed aGCM) were assigned over the course of the management. Patients were assigned risk status (high, low, or moderate) based on the composite clinical picture at time points in management. RESULTS Considering all cases and controls and results of prospectively obtained biosamples analyzed for miR371 expression, 46 (35%) of 132 samples had clinically confirmed aGCM over the course of management; 44 (96%) of these 46 patients had plasma miR371 expression (true positives) with no false positives. Two (4%) of 46 patients had no miRNA expression despite pathologic confirmation of aGCM (false negatives). Plasma miR371 expression in confirmed aGCM had a specificity, sensitivity, positive predictive value, and negative predictive value of 100%, 96%, 100%, and 98%, respectively. Interpretation of sensitivity and negative predictive value is limited by modest follow-up. Specificity and sensitivity were 100% and 98%, 100% and 92%, and 100% and 97% in the low-, moderate-, and high-risk groups, respectively, with a median follow-up time of 15 months. CONCLUSION Plasma miR371 expression predicts aGCM with high specificity and positive predictive value. Although other operating characteristics of miR371 await longer follow-up for more complete definition, the findings of a highly specific liquid biopsy strongly support moving forward with large-scale, real-world clinical trials to further define full operating characteristics and to identify clinical utility and areas of patient benefit.
Treatment of Childhood Nasopharyngeal Carcinoma With Induction Chemotherapy and Concurrent Chemoradiotherapy: Results of the Children’s Oncology Group ARAR0331 Study
Authors: Rodriguez-Galindo Carlos , Krailo Mark D. , Krasin Matthew J. , Huang Li , McCarville M. Beth , Hicks John , Pashankar Farzana , Pappo Alberto S. 
Published: September 2019

PURPOSE The treatment of childhood nasopharyngeal carcinoma has been adapted from adult regimens; pediatric-specific studies are limited. The ARAR0331 study sought to evaluate the impact of induction chemotherapy (IC) and concurrent chemoradiotherapy (CCR). PATIENTS AND METHODS Patients with American Joint Committee on Cancer stages IIb to IV were scheduled to receive three cycles of IC with cisplatin and fluorouracil, followed by CCR with three cycles of cisplatin. Patients with complete or partial response to IC received 61.2 Gy to the nasopharynx and neck, and patients with stable disease received 71.2 Gy. RESULTS Between February 2006 and January 2012, 111 patients (75 male) were enrolled. Median age was 15 years, and 46.8% of the patients were African American. After a feasibility analysis, the study was amended to reduce cisplatin to two cycles during CCR. The 5-year event-free survival (EFS) and overall survival estimates were 84.3% and 89.2%, respectively. The 5-year EFS for stages IIb, III, and IV were 100%, 82.8%, and 82.7%, respectively. The 5-year cumulative incidence estimates of local, distant, and combined relapse were 3.7%, 8.7%, and 1.8%, respectively. Patients treated with three versus two CCR cycles of cisplatin had improved 5-year postinduction EFS (90.7% v 81.2%, P = .14). CONCLUSION Patients in ARAR0331 were characterized by advanced disease and by a high proportion of black children and adolescents. Treatment with IC and CRT resulted in excellent outcomes. A radiation dose reduction is possible for patients responding to IC. Although the outcomes are comparable, we observed a trend toward decreased EFS for patients assigned to receive fewer doses of cisplatin during CCR.
Relationship Between Number of Multiple Risk Factors and Coronary Artery Disease Risk With and Without Diabetes Mellitus
Authors: Yamada-Harada Mayuko , Fujihara Kazuya , Osawa Taeko , Yamamoto Masahiko , Kaneko Masanori , Kitazawa Masaru , Matsubayashi Yasuhiro , Yamada Takaho , Yamanaka Nauta , Seida Hiroyasu , Ogawa Wataru , Sone Hirohito 
Published: September 2019

Abstract

Purpose
To determine the degree of control of multiple risk factors under real-world conditions for coronary artery disease (CAD) according to the presence or absence of diabetes mellitus (DM) and to determine whether reaching multifactorial targets for blood pressure (BP), low-density lipoprotein-cholesterol (LDL-C), HbA1c, and current smoking is associated with lower risks for CAD.

Methods
We investigated the effects on subsequent CAD of the number of controlled risk factors among BP, LDL-C, HbA1c, and current smoking in a prospective cohort study using a nationwide claims database of 220,894 individuals in Japan. Cox regression examined risks over a 4.8-year follow-up.

Results
The largest percentage of participants had two risk factors at target in patients with DM (39.6%) and subjects without DM (36.4%). Compared with those who had two targets achieved, the risks of CAD among those who had any one and no target achieved were two and four times greater, respectively, regardless of the presence of DM. The effect of composite control was sufficient to bring CAD risk in patients with DM below that for subjects without DM with any two targets achieved, whereas the risk of CAD in the DM group with all four risk factors uncontrolled was 9.4 times more than in the non-DM group who had achieved two targets.

Conclusions
These findings show that composite control of modifiable risk factors has a large effect in patients with and without DM. The effect was sufficient to bring CAD risk in patients with DM below that in the non-DM group who had two targets achieved.
Proteomics study of the antifibrotic effects of α-mangostin in a rat model of renal fibrosis
Authors: Chaeyklinthes Thana , Tiyao Vilailak , Roytrakul Sittiruk , Phaonakrop Narumon , Showpittapornchai Udomsri , Pradidarcheep Wisuit 
Published: September 2019

Abstract

Background
Renal fibrosis is a consequence of a “faulty” wound-healing mechanism that results in the accumulation of extracellular matrix, which could lead to the impairment of renal functions. α-Mangostin (AM) may prevent the formation of liver fibrosis, but there has yet to be a conclusive investigation of its effect on renal fibrosis.

Objectives
To investigate the renoprotective effect of AM against thioacetamide (TAA)-induced renal fibrosis in rats at the morphological and proteomic levels.

Methods
We divided 18 male Wistar rats into 3 groups: a control group, a TAA-treated group, and a TAA + AM group. The various agents used to treat the rats were administered intraperitoneally over 8 weeks. Subsequently, the morphology of renal tissue was analyzed by histology using Sirius Red staining and the relative amount of stained collagen fibers quantified using ImageJ analysis. One-dimensional gel liquid chromatography with tandem mass spectrometry (GeLC-MS/MS) was used to track levels of protein expression. Proteomic bioinformatics tools including STITCH were used to correlate the levels of markers known to be involved in fibrosis with Sirius Red-stained collagen scoring.

Results
Histology revealed that AM could reduce the relative amount of collagen fibers significantly compared with the TAA group. Proteomic analysis revealed the levels of 4 proteins were modulated by AM, namely CASP8 and FADD-like apoptosis regulator (Cflar), Ragulator complex protein LAMTOR3 (Lamtor3), mitogen-activated protein kinase kinase kinase 14 (Map3k14), and C-Jun-amino-terminal kinase-interacting protein 3 (Mapk8ip3).

Conclusion
AM can attenuate renal fibrosis by the suppression of pathways involving Cflar, Lamtor3, Map3k14, and Mapk8ip3.
Anatomy of the vasculature supplying hepatobiliary structures and celiac trunk branching patterns in the Thai population
Authors: Nateniyom Natcha , Huanmanop Thanasil , Agthong Sithiporn , Chentanez Vilai 
Published: September 2019

Abstract

Background
Knowledge of the anatomy of the celiac trunk (CT) and arterial supply of the hepatobiliary system is essential for surgical and interventional radiological treatment of upper abdominal diseases.

Objectives
To determine the branching patterns of the CT and variation in origin and type of the right hepatic artery (RHA), left hepatic artery (LHA), and cystic artery (CA).

Methods
The anatomy of the CT in 100 cadavers from Thai adult donors was observed in 3 aspects: its branching pattern, the origin of the RHA and LHA, and the origin of the CA and its relation to the common bile duct (CBD) and common hepatic duct (CHD).

Results
The majority of the CT branching pattern was categorized as the type II classical pattern, which has 3 branches: the left gastric artery (LGA), splenic artery (SA), and common hepatic artery (CHA). The RHA branched from proper hepatic artery in 67 cadavers. The origin of the accessory RHA was either from the abdominal aorta or superior mesenteric artery (SMA), whereas the replaced RHA originated from the CHA, SMA, or CT. The accessory LHA ramified from CHA (2 cases) and LGA (1 case). The replaced LHA was found in 30 cadavers and 29 arose from the CHA. The single and double types of CA were found in 94 and 4 cadavers, respectively. In all, 57% of single CA passed posteriorly and 39% passed anteriorly to the CBD and CHD.

Conclusions
To lower posttreatment complications, variations in the anatomy and the vascular supply of hepatobiliary structures should be considered.
Behavioral and histopathological studies of cervical spinal cord contusion injury in rats caused by an adapted weight-drop device
Authors: Bamrungsuk Kanyaratana , Vattarakorn Anchalee , Thongta Namphung , Tilokskulchai Kanokwan , Tapechum Sompol , Chompoopong Supin 
Published: September 2019

Abstract

Background
Models of spinal cord injury (SCI) caused by weight-drop devices to cause contusion have been used extensively, and transient behavioral deficits after thoracic injury have been demonstrated. The severity of the injury caused by the device should be mild enough to allow recovery.

Objective
To determine whether our adapted weight-drop device with a small tip can effectively induce mild hemicontusion at the level of the fifth cervical vertebra.

Methods
We divided 15 adult male Sprague Dawley rats into groups of 5 for the following treatments: sham (SH, laminectomy only), mild (MSCI) or severe SCI (SSCI). Behavioral tests and histopathology were used before (day 1) and after the treatment on days 3, 7, 14, 21, 28, and 35 to assess the injury.

Results
Rats with SSCI showed a significant somatosensory deficit on days 3 and 7 compared with rats in the SH group, recovering by day 14. In a horizontal-ladder test of skilled locomotion, rats with SSCI showed a significant increase in error scores and percentage of total rungs used, and a decrease in the percentage of correct paw placement compared with rats in the SH group. There was greater recovery to normal paw placement by rats with MSCI than by rats with SSCI. These behavioral deficits were consistent with histopathology using hematoxylin and eosin counterstained Luxol fast blue, indicating the degree of injury and lesion area.

Conclusions
Mild hemicontusion caused by the adapted device can be used to evaluate SCI and provides a model with which to test the efficacy of translational therapies for SCI.
Repeatability and reproducibility of lipoprotein particle profile measurements in plasma samples by ultracentrifugation
Authors: Monsonis-Centelles Sandra , Hoefsloot Huub C.J. , Engelsen Søren B. , Smilde Age K. , Lind Mads V. 
Published: September 2019

Abstract

Background
Characterization of lipoprotein particle profiles (LPPs) (including main classes and subclasses) by means of ultracentrifugation (UC) is highly requested given its clinical potential. However, rapid methods are required to replace the very labor-intensive UC method and one solution is to calibrate rapid nuclear magnetic resonance (NMR)-based prediction models, but the reliability of the UC-response method required for the NMR calibration has been largely overlooked.

Methods
This study provides a comprehensive repeatability and reproducibility study of various UC-based lipid measurements (cholesterol, triglycerides [TGs], free cholesterol, phospholipids, apolipoprotein [apo]A1 and apoB) in different main classes and subclasses of 25 duplicated fresh plasma samples and of 42 quality control (QC) frozen pooled plasma samples of healthy individuals.

Results
Cholesterol, apoA1 and apoB measurements were very repeatable in all classes (intraclass correlation coefficient [ICC]: 92.93%–99.54%). Free cholesterol and phospholipid concentrations in main classes and subclasses and TG concentrations in high-density lipoproteins (HDL), HDL subclasses and low-density lipoproteins (LDL) subclasses, showed worse repeatability (ICC: 19.21%–99.08%) attributable to low concentrations, variability introduced during UC and assay limitations. On frozen QC samples, the reproducibility of cholesterol, apoA1 and apoB concentrations was found to be better than for the free cholesterol, phospholipids and TGs concentrations.

Conclusions
This study shows that for LPPs measurements near or below the limit of detection (LOD) in some of the subclasses, as well as the use of frozen samples, results in worsened repeatability and reproducibility. Furthermore, we show that the analytical assay coupled to UC for free cholesterol and phospholipids have different repeatability and reproducibility. All of this needs to be taken into account when calibrating future NMR-based models.
Preparation and spectroscopic studies of Fe(II), Ru(II), Pd(II) and Zn(II) complexes of Schiff base containing terephthalaldehyde and their transfer hydrogenation and Suzuki-Miyaura coupling reaction
Authors: Turan Nevin , Buldurun Kenan , Çolak Naki , Özdemir İsmail 
Published: September 2019

AbstractThis study describes synthesis, spectroscopic characterization and catalytic activities of Fe(II), Ru(II), Pd(II) and Zn(II) complexes with a novel Schiff base ligand (L) derived from methyl 2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate and terephthalaldehyde. We used spectroscopic techniques including IR, UV-Vis, 1H-NMR, 13C-NMR, elemental analysis and also mass analysis and magnetic susceptibility measurements to identify the products. The Pd(II) complex was used as a potential catalyst for Suzuki-Miyaura coupling reaction of some aryl halides under optimized conditions. The effect of various bases such as NaOH, KOH, and KOBut was investigated in transfer hydrogenation (TH) of ketones by isopropyl alcohol as the hydrogen source. Ru(II) and Pd(II) complexes showed catalytic activity while Zn(II) and Fe(II) metal complexes failed to do that.
Large-area pixelated metasurface beam deflector on a 12-inch glass wafer for random point generation
Authors: Li Nanxi , Fu Yuan Hsing , Dong Yuan , Hu Ting , Xu Zhengji , Zhong Qize , Li Dongdong , Lai Keng Heng , Zhu Shiyang , Lin Qunying , Gu Yuandong , Singh Navab 
Published: September 2019

Abstract
Metasurface-based beam deflector, as an important optical element to bend the light propagation direction, has drawn a lot of interests in research to achieve miniaturization of devices and reduction of system complexity. Based on the 12-inch immersion lithography technology, in this work, an ultra-thin and large-area pixelated metasurface beam deflector with a footprint of 2500 × 2500 μm, formed by nanopillars with diameters from 221 to 396 nm, is demonstrated on a 12-inch glass wafer. The 21 × 21 array of deflectors is designed to bend the input light in different directions and to generate 441 random points. In addition, the layer transfer on the 12-inch glass wafer makes the device working in transmission mode at a 940-nm wavelength. The random point array generated from the experiment shows good match with the design. This pixelated metasurface beam deflector can generate random points simultaneously and has potential to make beam steering by switching each pixel of the beam deflector, which can be applied on motion detection, facial recognition, and light detection and ranging.
INFORMAÇÕES EDITORIAIS
Authors: Farias Bruno Matos de , Avelar Katia Eliane Santos 
Published: September 2019

A revista Semioses: Inovação, Desenvolvimento e Sustentabilidade é uma publicação trimestral do Programa de Pós-Graduação em Desenvolvimento Local, do Centro Universitário Augusto Motta. Tem como foco temas interdisciplinares voltados para as Ciências Ambientais e áreas afins. Desse modo, são bem-vindos artigos que versem sobre as questões ambientais e o desenvolvimento sustentável, como a proteção de biomas, erradicação de pobreza, direitos humanos, cidadania, novas tecnologias, educação básica, empreendedorismo, reutilização de matérias primas, construções sustentáveis, energias limpas, inovações tecnológicas, saúde coletiva, produtos e alimentos saudáveis.
The Impact of Physical Activity on Brain Structure and Function in Youth: A Systematic Review
Authors: Valkenborghs Sarah Ruth , Noetel Michael , Hillman Charles H. , Nilsson Michael , Smith Jordan J. , Ortega Francisco B. , Lubans David Revalds 
Published: September 2019

CONTEXT:
Advances in neuroimaging techniques have resulted in an exponential increase in the number of studies investigating the effects of physical activity on brain structure and function. Authors of studies have linked physical activity and fitness with brain regions and networks integral to cognitive function and scholastic performance in children and adolescents but findings have not been synthesized.

OBJECTIVE:
To conduct a systematic review of studies in which the impact of physical activity on brain structure and function in children and adolescents is examined.

DATA SOURCES:
Six electronic databases (PubMed, PsychINFO, Scopus, Ovid Medline, SportDiscus, and Embase) were systematically searched for experimental studies published between 2002 and March 1, 2019.

STUDY SELECTION:
Two reviewers independently screened studies for inclusion according to predetermined criteria.

DATA EXTRACTION:
Two reviewers independently extracted data for key variables and synthesized findings qualitatively.

RESULTS:
Nine studies were included (task-based functional MRI [n = 4], diffusion tensor imaging [n = 3], arterial spin labeling [n = 1], and resting-state functional MRI [n = 1]) in which results for 5 distinct and 4 similar study samples aged 8.7 ± 0.6 to 10.2 ± 1.0 years and typically of relatively low socioeconomic status were reported. Effects were reported for 12 regions, including frontal lobe (n = 3), parietal lobe (n = 3), anterior cingulate cortex (n = 2), hippocampus (n = 1), and several white matter tracts and functional networks.

LIMITATIONS:
Findings need to be interpreted with caution as quantitative syntheses were not possible because of study heterogeneity.

CONCLUSIONS:
There is evidence from randomized controlled trials that participation in physical activity may modify white matter integrity and activation of regions key to cognitive processes. Additional larger hypothesis-driven studies are needed to replicate findings.
Modul Elektronika Berbasis Mikrokontroler sebagai Sistem Pengaman pada Mobil Terintegrasi dengan Engine Immobilizer
Authors: Goeritno Arief , Afandi Muhammad Yusuf 
Published: September 2019

An electronic module based on the ATmega32 microcontroller as a security system for cars that integrated into the engine immobilizer has been created. Three main things in this study, namely programming and verification tests, making an initial security system with a minimalist structure, and validation tests. Programming for the microcontroller system through algorithm determination and syntax writing, while the verification test is done through uploading the program syntax to the Proteus application and implementing the simulation. Determining the algorithms and writing the syntax through a number of steps, namely pin configuration, variable declarations, constant declarations, initialization, main programs, retrieve and send data, and output. The simulation assisted by the Proteus application is in the form of giving two kinds of commands/inputs to the sensor, namely one input data in the form of human existence or human motion to the passive infrared receiver sensor and one input of human fingerprint initialization data to the fingerprint sensor. The simulation results according to the order of the fingerprint sensor and passive infrared receiver in the form of a display on the Virtual Terminal. The minimalist structure of the system is composed of circuit diagrams, physical forms, and integrated wiring on the ATmega32 microcontroller system. The performance of the security system is shown, that the results of monitoring when the sensor is given input "human existence (motion)", the fingerprint sensor blinks (on) and when the fingerprint sensor blinks which means ready to receive input data in the form of "Human Initialization (fingerprint)" for activating actuators and starter system on the car. Giving input commands to the sensor passive infrared receiver and fingerprint has functioned for the appointment of performance, that the initial security system has been integrated with the main security systemand attached to the car.
Pemanfaatan Fasilitas IT untuk Jaringan Pencahayaan LED di Smartroom
Authors: Manfaluthy Mauludi , Wilyanti Sinka 
Published: September 2019

In this research, proposed lighting in smartroom with PoE technology (Power over Ethernet). IT facility is PoE Switch, Ethernet Cable and LAN network. Smartroom in this study is defined as meeting room in a high rise building that has LAN network. This research is motivated by many lighting lamps that use AC power, when the future use of AC source will be reduced, even with PoE switch voltage source still use AC, but can eliminate the pitch of light that still uses conventional AC. Building infrastructure systems tend to be developed towards IP protocols. An area where the electrical area becomes fully integrated into the IP network. This is made possible through the use of LED with low voltage and low current. However, in order to utilize the technical and economic advantages offered by LED Lighting Solutions, the addition of light sensor and motion as a switch will make it more complete. The results of the study obtained a cheaper cost than the use without PoE.