bluuebunny/crossref_metadata_2025_split huggingface dataset:
La integración de la Agenda 2030 en la política turística: el caso de España
Authors: Gómez-Bruna Diana , Millán-Acevedo Natalia , Velasco-González María 
Published: November 2024

Desde hace años, la sostenibilidad es uno de los grandes retos de la política turística. En este contexto, la Agenda 2030 puede convertirse en una importante herramienta para trabajar en el progreso hacia la sostenibilidad del sector turístico por tratarse de una agenda integral y transversal, que incluye las esferas económica, social y medioambiental desde una perspectiva indivisible. Con el presente artículo, se tiene como objetivo analizar la integración de la Agenda 2030 en la política turística española. Para ello se utiliza la metodología cualitativa a través de la técnica de análisis de contenido de los documentos rectores de esta política sectorial en España. Se abordan tres dimensiones de análisis: problemas, valores y Objetivos de Desarrollo Sostenible (ODS). Los resultados muestran que, a pesar de que la política turística española incorpora algunas cuestiones clave de la Agenda 2030, tiene un mayor enfoque hacia las dimensiones económica y medioambiental mientras que la dimensión social se incorpora de una manera más limitada. Estos hallazgos muestran que la política turística tiene sus propios intereses y lógicas desde los cuales abordar cada una de las dimensiones de la sostenibilidad.
Mapping of Indigenous Knowledge Research in India: A Review of Growth, Emerging Topics and Future Research Directions based on Scientometric Tools
Authors: Basumatary Bwsrang , Robin K , Arvind  , Verma Manoj Kumar 
Published: November 2024

The study of indigenous knowledge in India has evolved over the years and gained significant importance as a vital area of research. This study aimed to explore the evolution of the research landscape on indigenous knowledge in India over the last twenty years (2003-2022), focusing on growth trends and knowledge mapping through Scientometric tools. The study collected 1,980 data from the Scopus database, indexed between 2003 and 2022. Initially, the analysis focused on measuring the research growth and performance of the key players. Then, the study performed scientific knowledge mapping, visualizing the relationships between different concepts and topics within the field. The findings reveal a significant growth in indigenous knowledge research in India. The study also identified key research themes, including traditional medicine, agriculture, biodiversity conservation, etc. In the early two decades, research was conducted on natural resource management, ethnoveterinary practices, ethnomedicine, biodiversity, tribal communities, and traditional healers, etc. The most recent research topics were COVID-19, sustainability, livelihood, ethnopharmacology, climate change, herbal drugs, etc. Research on medicinal plants and ethnobotany was the most influential in the last two decades. Furthermore, the study revealed a highly interconnected network of authors and institutions, with a few key players dominating the field. The study concludes by highlighting the need for further research on indigenous knowledge in India, particularly in areas such as intellectual property rights, geographical identification, preservation, and the role of indigenous knowledge in sustainable development.
Luonteenvahvuuksien hyödyntäminen aikuisten suomen kielen oppimisessa
Authors: Scotson Mia 
Published: November 2024

In this article, I will explore how to utilize character strengths in Finnish language learning. This study relies on VIA strengths inventory (Peterson & Seligman 2004). I will examine which character strengths adult Finnish learners utilize and how character strengths are related to learning Finnish, as well as participants’ beliefs regarding character strength intervention. The data of this qualitative study consist of an online questionnaire (n=32), individual and group info meetings online (n=21), character strengths intervention (n=8) and final interviews (n=4). The data were analyzed using content analysis. The results indicate that while some strengths are easily applicable to learning Finnish, others prove challenging to employ in language learning. Furthermore, the findings suggest that while participants found the character strength exercise interesting and enlightening, they expressed a desire for examples demonstrating the application of strengths, along with guidance on identifying and utilizing them.
Language and spatiality in the study of migrants’ integration into Finnish working life: Building bridges between applied linguistics and geography
Authors: Jousmäki Henna , Lehto Liisa-Maria , Pienimäki Hanna-Mari , Iikkanen Päivi 
Published: November 2024

While several studies have addressed migrants’ status at the Finnish job market as well as multicultural and multilingual workplace interaction, there is a lack of research that ties these more closely with questions of spatiality. Through discourse analysis, this article examines the interrelationships of language, work, and place in three data sets collected around Finland. The purpose is to better understand how experiential place and geographical space matter in the discourses construed of and by migrants working or seeking employment in Finland. The findings show that different understandings of spatiality feed into one another and affect employment opportunities, requirements for language skills in the workplace and how the relationship between language competence and professional skills is challenged and negotiated.
Classification of Cell Therapy Products by Cell Manipulation Degree and Functions Performed: Analysis of International Regulatory Approaches
Authors: Vodyakova M. A. , Pokrovsky N. S. , Semenova I. S. , Merkulov V. A. , Melnikova E. V. 
Published: November 2024

INTRODUCTION. The degree of processing (manipulation) of cells included in a cell product and the functions performed after administration (homologous/non-homologous use) determine the classification of the cell product as a transplant or an advanced therapy medicinal product (ATMP) and, hence, the regulatory aspects of the product’s life cycle. Currently, the legislation of the Eurasian Economic Union (EAEU) and the Russian Federation does not sufficiently explain the terms ‘minimal manipulation’ and ‘homologous/non-homologous use’, which may lead to the use of cell products with unproven safety and efficacy in humans.AIM. This study aimed to compare Russian and international approaches to the interpretation of the terms ‘minimal manipulation’ and ‘homologous/non-homologous use’ for classifying cell products and determining their regulatory pathways, with stromal vascular fraction (SVF) products used as an example.DISCUSSION. This article reviews and summarises the regulatory approaches of the Russian Federation, the EAEU, the United States (US), and the European Union (EU) that are based on the classification of cell products according to the degree of cell manipulation and the functions performed after administration. The authors have analysed and compared the regulatory acts and approaches of the countries under consideration, with SVF products as a case study. The article highlights general aspects of interpreting the terms ‘minimal manipulation’ and ‘homologous/ non-homologous use’ and demonstrates the difference in regulatory approaches across several countries, which lies in the classification of enzymatic processing and selective collection of cells as substantial or minimal manipulation.CONCLUSIONS. The mechanism for regulating cell products depends on the degree of cell manipulation (substantial or minimal) and the intended use (homologous or non-homologous). A common principle adopted by regulatory agencies in the US, EU, EAEU, and Russia is to classify manipulation as minimal if the manipulated cells preserve their biological characteristics and physiological function. A defining characteristic of the homologous use of cells or tissues is their administration to perform their inherent functions in the body. In Russia, the regulatory acts for ATMPs and for transplants list the procedures classified as minimal manipulation. According to international standards, preparations based on minimally manipulated SVF cells are classified as ATMPs when used non-homologously. The lack of comprehensive and clear explanations of the terms ‘minimal manipulation’ and ‘homologous/non-homologous use’ in the legislation of the EAEU and the Russian Federation necessitates the development of relevant guidelines providing specific examples.
State Pharmacopoeia of the Russian Federation Edition XV: Development Priorities
Authors: Yarutkin A. V. , Bagirova V. L. 
Published: November 2024

INTRODUCTION. Regular reviews of the current portfolio of general chapters and monographs are essential to ensure the well-balanced development of the State Pharmacopoeia of the Russian Federation (Ph. Rus.) in line with the priorities of the national healthcare system.AIM. This study aimed to identify the most promising areas for further Ph. Rus. development through an analysis of recent legislative changes in Russia and the current compendial portfolio.DISCUSSION. This article compares Ph. Rus. editions XIV and XV, analyses the key features and structure of edition XV, and reviews amendments to the regulations governing the Ph. Rus. publication. The current compendial portfolio is dominated by monographs on chemical active substances; it also includes a substantial number of monographs on herbal drugs and herbal drug preparations. Noteworthy, edition XV is the first Ph. Rus. edition to include a separate section dedicated to monographs on excipients necessary for the development of pharmacy compounding. Moreover, this article analyses the coverage of active substances that are used for the production of listed vital and essential medicines.CONCLUSIONS. The authors outlined the priority areas for the development of quality standardisation. The Ph. Rus. should continue developing monographs on active substances that are used for the manufacturing and compounding of listed vital and essential medicines. In addition, the coverage of herbal drugs should be expanded. The Ph. Rus. should develop monographs on excipients that are used for the manufacturing and compounding of medicinal products. Finally, the Ph. Rus. should complete the development of requirements for biological medicinal products and relevant test methods.
The results of the assessment of burnout syndrome in outpatient clinic staff for the development of personalized rehabilitation
Authors: Kireeva Victoria V. , Usoltsev Yuri K. , Zaika Alena A. , Lepekhova Svetlana A. , Kurganskiy Ilya S. 
Published: November 2024

In conditions of increased workload on the medical staff of outpatient clinics, the need to preserve their physical and mental health, reduce the socially significant consequences of emotional burnout comes first, which makes it necessary to search for new directions of prevention, correction and rehabilitation using personalized medicine methods.
The study aims to assess the state of health and the syndrome of emotional burnout in medical workers of the outpatient clinic.
Specialists have examined 100 medical workers of outpatient and inpatient departments of the medical institution in equal numbers. The average age of outpatient medical staff was 49 [46;59] years, and inpatient — 43 [33;53] years. The average work experience of the examined medical personnel was the same both in outpatient settings (20 [16;28] years) and in hospital (20 [13;31] years). The authors have performed general clinical, laboratory and instrumental examinations. In addition to the standard examination scheme, the scientists assessed emotional burnout using the V.V. Boyko method and the quality of life according to the EQ-5D questionnaire in modification 3L and the hospital anxiety and depression scale HADS, and also conducted a questionnaire on a new coronavirus infection and the detection of post-COVID syndrome.
As a result of the study, the authors proved a decrease in the psychological and physical components of the quality of life of medical workers, which are associated with both work experience and a new coronavirus infection. It was confirmed that according to the results of the Boyko questionnaire, employees of the outpatient clinic, compared with their colleagues from the hospital, often have a higher unfavorable total score. According to the results of the survey, we observe an improvement in the psychological and physical components of the quality of life of medical personnel after individual rehabilitation.
This study showed the importance of assessing the state of health and emotional burnout syndrome in medical workers, high scores were revealed according to the Boyko questionnaire.
Limitations. This study is limited to a sex-and-age sample of medical staff at a medical institution.
Ethics. The study was conducted in accordance with the Helsinki Declaration "Recommendations for Doctors on Biomedical research in Humans" (2013), the World Association "Ethical Principles of Scientific Medical Research with Human Participation" as amended in 2000 and the "Rules of Clinical Practice in the Russian Federation", approved by Order of the Ministry of Health and Social Development of the Russian Federation No. 266 dated 06/19/2003, according to the developed protocol.
Pengenalan Aplikasi Quizizz Sebagai Media Pembelajaran pada Materi Konsep Getaran di SMA Teruna Bakti Waena Jayapura
Authors: Sinaga Ego Srivajawaty , Ngaderman Hubertus , Anou Kezia Noviani , Saputrina Truly Theresia , Sudrajad Bangkit , Tulak Noper , Napitupulu Daniel 
Published: November 2024

Mengenal aplikasi Quizizz sebagai media pembelajaran interaktif di era digital merupakan hal yang penting untuk diketahui oleh guru dan siswa. Tercapainya pembelajaran mandiri dengan konsep pembelajaran berdiferensiasi tentu memerlukan fasilitas pendukung. Tak heran jika pemanfaatan teknologi untuk mengoptimalkan pembelajaran mulai banyak digunakan dalam dunia pendidikan. Kegiatan pengabdian yang dilakukan adalah Memperkenalkan aplikasi Quizizz sebagai alat bantu pembelajaran materi konsep getaran di SMA Teruna Bakti Waena Jayapura dengan tujuan membantu guru dan siswa untuk lebih memahami cara penggunaan aplikasi Quizizz dan lebih semangat dalam belajar fisika sehingga memiliki pemahaman yang baik tentang konsep getaran. Hasil dari kegiatan yang dilakukan, siswa dan guru memahami cara penggunaan aplikasi Quizzizz dan siswa lebih tertarik dalam pembelajaran fisika, terbukti dengan nilai rata-rata yang dicapai sebesar 87.
Aktivitas Antioksidan Ekstrak Etanol, Etil Asetat, Dan n-Heksan Biji Mengkudu (Morinda Citrifolia L.) Dengan Metode DPPH
Authors: Nurisyah Nurisyah , Irawati Irawati , Salasa Alfrida Monica , Asyikin Asyhari 
Published: November 2024

Antioxidant Activity of Ethanol, Ethyl Acetate, and n-Hexane Extracts of Noni Seeds (Morinda Citrifolia L.) Using the DPPH Method
Antioxidants are compounds that can reduce the negative impact of free radicals. Noni seeds (Morinda citrifolia L.) contain these compounds as secondary metabolites. This research is a laboratory observational study to determine and compare the antioxidant activity of ethanol extract, ethyl acetate extract, and n-hexane extract noni seeds (Morinda citrifolia L.) using the 1,1-diphenyl-2- picrylhydrazyl method. Then the absorption was measured with a UV-Vis Spectrophotometer at the maximum wavelength (516 nm). The results showed that the IC50 value of the ethanol extract of noni fruit seeds was 507.75 ppm and the IC50 value of the ethyl acetate extract of noni fruit seeds was 43.18 ppm, while the n-hexane extract of noni fruit seeds had inactive antioxidant activity. The antioxidant activity of the ethanol extract of noni seeds is in the weak category and the antioxidant activity of the ethyl acetate extract is in the very strong category. The extracting solution that produces noni seed extract with the highest antioxidant activity is ethyl acetate solvent.
Antioksidan adalah senyawa yang dibutuhkan untuk mencegah dampak buruk dari radikal bebas. Biji Mengkudu (Morinda citrifolia L.) mengandung senyawa tersebut sebagai metabolit sekundernya. Penelitian ini merupakan penelitian observasi laboratorium untuk mengetahui aktivitas antioksidan ekstrak etanol, ekstrak etil asetat, dan ekstrrak n-heksana, Biji Mengkudu (Morinda citrifolia L.) dengan metode 1,1- difenil-2- picrylhydrazyl. Kemudian serapannya diukur dengan Spektrofotometer UV-Vis pada panjang gelombang maksimum (516 nm). Hasil penelitian menunjukkan bahwa nilai IC50 ekstrak etanol Biji Mengkudu adalah 507,75 ppm dan nilai IC50 ekstrak etil asetat Biji Mengkudu adalah 43,18 ppm sedangkan ekstrak n-heksana Biji Mengkudu memiliki aktivitas antioksidan yang tidak aktif. Aktivitas antioksidan ekstrak etanol Biji Mengkudu termasuk dalam kategori lemah dan aktivitas antioksidan ekstrak etil asetatnya termasuk kategori sangat kuat. Larutan pengekstrak yang menghasilkan ekstrak Biji Mengkudu dengan aktivitas antioksidan paling tinggi adalah pelarut etil asetat.
Meningkatkan Media Pancingan Huruf Untuk Meningkatkan Pengenalan Huruf Konsonan Pada Anak Tunagrahita Ringan
Authors: Firnianti Putri Dinda , Setia Budi  , Iswari Mega , Zulmiyetri Zulmiyetri , Arnez Gaby 
Published: November 2024

Abstrak: Penelitian dilatarbelakangi dari permasalahan yang ditemukan di kelas IV SLB Negeri 2 Pariaman yang masih belum mampu mengenal huruf konsonan D, F, G, H. Penelitian ini bertujuan untuk meningkatkan kemampuan mengenal huruf konsonan D, F, G, H melalui media pancingan huruf. Penelitian ini menggunakan pendekatan kuantitatif dengan metode penelitian eksperimen berbentuk Single Subject Research (SSR). Desain Penelitian yang digunakan adalah Desain A-B. Desain A-B terdiri dari 2 Kondisi yaitu Baseline (A1) dan B (Intervensi). Hasil Penelitian menunjukkan dalam 12 kali pertemuan, yaitu pada kondisi Baseline (A1) dengan presentase 25%,25%,25%,25%. Pada Kondisi Intervensi (B) dengan presentase 50%,50%,59%,67%,75%,84%,84%,84%. Berdasarkan hasil presentase penelitian tersebut dan analisis data baik dalam kondisi dan antar kondisi Media Pancingan Huruf dapat meningkatkan kemampuan mengenal huruf konsonan D, F, G, H bagi anak tunagrahita kelas IV SLB Negeri 2 Pariaman.
Kata-kata Kunci: Tunagrahita, Media Pancingan Huruf. Huruf Konsonan
Meningkatkan Keterampilan Membuat Sabun Cuci Piring melalui Model Project Based Learning pada Siswa Tunagrahita Ringan
Authors: Erlina Resti , Budi Setia , Damri  , Ardisal  
Published: November 2024

Penelitian ini bertujuan untuk meningkatkan keterampilan membuat sabun cuci piring melalui model Project Based Learning. Penelitian tindakan kelas akan berlangsung selama dua siklus yang terdiri dari tahap perencanaan, tindakan, observasi dan refleksi. Proses mengumpulkan data dilakukan dengan memakai teknik observasi, tes, dan dokumentasi. Hasil penelitian ini menunjukkan adanya peningkatan setelah pemberian tindakan pada siklus I dan siklus II. Siswa yang berinisial KA dengan nilai kemampuan awal 42,19%, kemudian meningkat pada siklus I dengan nilai 66,07% dan siklus II dengan nilai 89,28%. Sedangkan pada siswa yang berinisial NA nilai kemampuan awal 46,87%, kemudian pada siklus I meningkat dengan nilai 71,42% dan siklus II dengan nilai 94,64%. Maka, kesimpulan dari hasil penelitian ini adalah model Project Based Learning dapat meningkatkan keterampilan membuat sabun cuci piring pada siswa tunagrahita ringan.
Refrigerated amniotic membrane maintains its therapeutic qualities for 48 hours
Authors: Stelling-Férez J. , Puente-Cuadrado J. M. , Álvarez-Yepes V. , Alcaraz S. , Tristante E. , Hernández-Mármol I. , Mompeán-Egea I. , García-Hernández A. M. , Nicolás F. J. 
Published: November 2024

During wound healing, the migration of keratinocytes is critical for wound closure. The application of amniotic membrane (AM) on wounds with challenging contexts (e.g., chronification and diabetic foot ulcer) has proven very successful. However, the use of AM for clinical practice has several restraints when applied to patients; the most important restriction is preserving AM’s therapeutic properties between its thawing and application onto the patient’s wound. Moreover, AM collection and processing requires a cleanroom, together with specialized staff and equipment, and facilities that are not usually available in many hospitals and healthcare units. In this publication, we kept previously cryopreserved AM at different temperatures (37°C, 20°C, and 4°C) in different media (DMEM high glucose and saline solution with or without human albumin) and for long incubation time periods after thawing (24 h and 48 h). HaCaT keratinocytes and TGF-β1-chronified HaCaT keratinocytes were used to measure several parameters related to wound healing: migration, cell cycle arrest rescue, and the expression of key genes and migration-related proteins. Our findings indicate that AM kept in physiological saline solution at 4°C for 24 h or 48 h performed excellently in promoting HaCaT cell migration compared to AM that had been immediately thawed (0 h). Indeed, key proteins, extracellular signal-regulated kinase (ERK) and c-Jun, were induced by AM at 4°C in saline solution. Similarly, cell proliferation and different genes related to survival, inflammation, and senescence had, in all cases, the same response as to standard AM. These data suggest that the handling method in saline solution at 4°C does not interfere with AM’s therapeutic properties.
Experimental and advanced equilibrium studies on the enhanced adsorption of phosphate, cadmium, and safranin dye pollutants using methoxy exfoliated glauconite
Authors: Abukhadra Mostafa R. , Fadl Allah Aya , Shaban Mohamed , Alenazi Noof A. , Alqhtani Haifa A. , Bin-Jumah May , Allam Ahmed A. , Bellucci Stefano 
Published: November 2024

Natural glauconite, as a mixed-layered clay mineral, was subjected to exfoliation processes, producing silicate monolayers or individual sheets that were further modified with methanol into methoxy exfoliated glauconite (Mth/EXG). The structure was assessed as an enhanced adsorbent for three types of common water contaminants, including phosphate (PO43-), safranin-O dye (SFR), and cadmium metal ions (Cd2+). The Mth/EXG structure achieved promising adsorption capacities at the saturation points equal to 269.9 mg/g for PO43-, 312 mg/g for SFR, and 234.5 mg/g for Cd2+ which are significantly better than the reported values for several studied adsorbents of higher costs and complex production procedures. The adsorption processes and the predicted regulated mechanisms in terms of the adsorbate/adsorbent interface were illustrated based on the steric and energetic findings that correspond to the applied monolayer equilibrium model of one energy site. The structure displays active site densities of 82.5 mg/g (PO43-), 136.3 mg/g (SFR), and 83.4 mg/g (Cd2+), which illustrate the high uptake performance of SFR. Also, the steric parameters reflected the suitability of each existing site to be filled with 4 ions of PO43-, SFR, and Cd2+. The adsorption energy (less than 40 kJ/mol) in conjunction with free adsorption energy from D-R model (8–16 kJ/mol) and steric parameters validate the dominant impact of the multi-ionic physical mechanisms (hydrogen bonding and van der Waals forces), in addition to the assistant impact of some weak chemical processes that might be assigned to the formed inner-sphere complex. Also, these reactions all occurred spontaneously with exothermic behaviors according to the thermodynamic functions. Additionally, the structure exhibit significant affinity for the studied pollutants even in the existing of completive chemical including anions, cations and organic molecules.