bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of Intravenous Iron in Dialysis
Authors: Hougen Ingrid , Collister David , Bourrier Mathieu , Ferguson Thomas , Hochheim Laura , Komenda Paul , Rigatto Claudio , Tangri Navdeep 
Published: February 2018

Background and objectives
The safety of intravenous iron dosing in dialysis is uncertain. Higher-dose intravenous iron may be associated with a higher risk of infections, cardiovascular events, hospitalizations, and mortality. This systematic review aimed to determine the safety of higher-dose versus lower-dose intravenous iron, oral iron, or no iron supplementation in adult patients treated with dialysis.

Design, setting, participants, & measurements
We searched Medline, EMBASE, Cochrane library, and CINAHL from inception to January 6, 2017 for randomized, controlled trials and observational studies comparing higher-dose intravenous iron with lower-dose intravenous iron, oral iron, or no iron in patients treated with dialysis that had all-cause mortality, infection, cardiovascular events, or hospitalizations as outcomes.

Results
Of the 2231 eligible studies, seven randomized, controlled trials and 15 observational studies met inclusion criteria. The randomized, controlled trials showed no association between higher-dose intravenous iron (>400 mg/mo for most studies) and mortality (six studies; n=970; pooled relative risk, 0.93; 95% confidence interval, 0.47 to 1.84; follow-up ranging from 35 days to 26 months) or infection (four studies; n=743; relative risk, 1.02; 95% confidence interval, 0.74 to 1.41). The observational studies showed no association between higher-dose intravenous iron (>200 mg/mo for most studies) and mortality (eight studies; n=241,408; hazard ratio, 1.09; 95% confidence interval, 0.98 to 1.21; follow-up ranging from 3 to 24 months), infection (eight studies; n=135,532; pooled hazard ratio, 1.13; 95% confidence interval, 0.99 to 1.28), cardiovascular events (seven studies; n=135,675; hazard ratio, 1.18; 95% confidence interval, 0.90 to 1.56), or hospitalizations (five studies; n=134,324; hazard ratio, 1.08; 95% confidence interval, 0.97 to 1.19).

Conclusions
Higher-dose intravenous iron does not seem to be associated with higher risk of mortality, infection, cardiovascular events, or hospitalizations in adult patients on dialysis. Strength of this finding is limited by small numbers of participants and events in the randomized, controlled trials and statistical heterogeneity in observational studies.
The Familias Saludables partnership: Engaging the Latino community to address early childhood obesity
Authors: Thompson Darcy A , Federspiel Deborah A 
Published: February 2018

Darcy A Thompson is an Associate Professor of pediatrics at the University of Colorado School of Medicine. Her main research seeks to address early childhood obesity in low-income children. She works in the Lifestyle Medicine clinic at Children’s Hospital Colorado, a clinic focused on caring for children with obesity and related comorbidities. She is also an Associate Medical Director for the Research Institute at Children’s Hospital Colorado. Her training includes a Master of Public Health degree, a medical degree (Yale University) and the Robert Wood Johnson Clinical Scholars Fellowship (University of Washington).
Deborah (Deb) A Federspiel has been leading child health advocacy and community health improvement initiatives in support of Children’s Hospital Colorado’s mission for the past 15 years. Her professional background includes experience developing and managing teams, programs and operations, as well as building partnerships and coalitions to drive key strategic initiatives and advance positive change on behalf of children and families. An active member of a number of community advisory committees and nonprofit boards, she has worked in the Colorado nonprofit sector since 1999. She has a Bachelor of Science in business administration from the University of Dayton.
Capital Market Union and residential capitalism in Europe: Rescaling the housing-centred model of financialization
Authors: Fernandez Rodrigo , Aalbers Manuel B. 
Published: February 2018

AbstractThis article examines the effects of implementing the proposals of the European Commission to institute a Capital Market Union (CMU) on the diverse landscape of residential capitalism in Europe. The CMU will bypass existing national institutional blockades that left core countries of the Eurozone, namely Germany, France and Italy, largely untouched by the housing-centred financialization that developed in countries like Spain, Ireland, the UK and the Netherlands. It is widely acknowledged that the rise in securitized mortgage debt contributed to the global financial crisis. As part of the CMU, the new European Commission is promoting mortgage securitization throughout the EU and thereby rescaling the political economy of housing finance that was hitherto rooted in national, institutional models. We argue that countries which ‘missed’ the previous housing boom will not be able to prevent future housing-centred financialization. CMU thus signifies a spatial expansion of the debt-led accumulation model.
Recurrent Aspergillus endocarditis in an immunocompetent patient: challenges in diagnosis and management
Authors: Beh Yuan Ye , Lim Grace Li Hsien , Stewart Andrew 
Published: February 2018

We describe an unusual case of recurrent Aspergillus endocarditis in an immunocompetent 64-year-old lady. Four weeks after aortic valve replacement surgery, she presented with an inferior ST elevation myocardial infarction. Coronary angiography demonstrated compromise of the ostium of the right coronary artery, which was successfully treated by primary angioplasty and stenting. Six weeks later, she suffered from a subarachnoid haemorrhage secondary to a mycotic aneurysm. A transoesphageal echocardiogram suggested a large aortic root vegetation. She underwent urgent aortic root replacement with removal of the vegetation, which was subsequently confirmed to be caused by Aspergillus. She was discharged on long term anti-fungal medication (Voriconazole), which she discontinued after seventeen weeks. Several years later, she presented with non-specific symptoms and was ultimately diagnosed with a recurrence of Aspergillus endocarditis. This case illustrates one of the many non-specific ways Aspergillus endocarditis can present. A high index of suspicion can prevent significant life-threatening complications.
PEMBUATAN APLIKASI KELAYAKAN KREDIT MIKRO PADA PT. BPD JAWA BARAT DAN BANTEN,TBK.
Authors: Putra Sandra Islama 
Published: February 2018

PT. BDP Jawa Barat dan Banten,Tbk merupakan salah satu Perbankan yang bergerak dalam bisnis peminjaman uang dan suatu lembaga intermediasi dalam negara, salah satu produknya kredit mikro, berkenaan hal tersebut bank menutut para karyawan dapat memberikan pelayanan yang terbaik dan memuaskan kepada nasabahnya. Di era yang modern ini, teknologi bukan merupakan hal yang baru terutama di perusahaan. Hampir semua perusahaan menggunakan teknologi dalam menjalankan, mengembangkan dan mendukung oprasional segala jenis perusahaan bisnis. Dengan seiring perkembangan teknologi dan ilmu pengetahuan maka informasi memiliki peranan yang sangat penting untuk mendukung pengambilan sebuah keputusan, sehingga sistem manual mulai ditinggalkan, dan digantikan dengan sistem komputerisasi. Hal ini dikarenakan sistem manual seringkali membuat kinerja perusahaan terhambat dan kurang optimal. Oleh sebab itu dibuatkanlah aplikasi yang akan membantu bagian analis kredit mikro, untuk pengambilan keputusan kelayakan nasabah yang akan mengajukan kredit. Penganalisisan kelayakan ini didasarkan atas syarat yang telah ditentukan oleh PT. BDP Jawa Barat dan Banten, Tbk. Untuk menyelesaikannya masalah ini dibuatkanlah aplikasi kelayakan kredit mikro terhadap nasabah yang layak mengajukan dan meneria kredit yang didukung dengan bahasa pemrograman Visual Basic dan Sql Server sebagai media penyimpanan data.
BUSINESS PLAN CV. CIHANJUANG INTI TEKNIK
Authors: Bachri Asep Saeful 
Published: February 2018

Seiring berkembangnya teknologi yang semakin modern memberikan pengaruh terhadap kegiatan ekonomi termasuk aktivitas bisnis pada suatu perusahaan, sehingga banyak terjadi persaingan yang kompetitif ditambah dengan adanya suatu perjanjian atau kerja sama di bidang Indsutri dan perdagangan yang dilakukan pemerintah Indonesia dengan negara lain yang disebut MEA. Dalam mengembangkan rencana bisnis atau business plan dimulai dengan analisis SWOT yang mencakup analisis Internal dan Eksternal perusahaan. Setelah analisis SWOT dibuat, maka selanjutnya menyusun rencana bisnis dimulai dari ringkasan eksekutif, uraian umum usaha, analisis aspek pemasaran sampai analisis aspek keuangan. Dari analisis SWOT didapatkan kekuatan, kelemahan, peluang, dan ancaman yang ada di perusahaan dan salah satu strategi dari hasil analisis SWOT yang menggunakan kekuatan dan peluang yang ada ialah Mempertahankan kualitas produk yang dimiliki oleh CV. Cihanjuang Inti Teknik yang ditujukan untuk para konsumen. Untuk hasil penyusunan rencana bisnis diketahui bahwa CV.Cihanjuang Inti Teknik bergerak pada industri makanan dan minuman tradisional khas Jawa Barat, memiliki potensi pasar yang baik, memiliki jenis produk yang beragam. Manajemen CV. Cihanjuang Inti Teknik sudah dapat dijalankan dengan baik dengan jumlah tenaga kerja yang ada sebanyak 53 orang. CV. Cihanjuang Inti Teknik memiliki nilai IRR sebesar 22,42%, dengan nilai ROI sebesar 17%. Dan nilai Profitability Index sebesar 1,37.
STUDI LAJU DEOKSIGENASI PADA SUNGAI CIKAPUNDUNG UNTUK RUAS SILIWANGI - ASIA AFRIKA, BANDUNG
Authors: Yustiani Yonik 
Published: February 2018

Sungai Cikapundung merupakan sungai terbesar di kota Bandung. Di pinggiran sungai dipadati oleh rumah-rumah penduduk dengan saluran buangannya yang langsung mengarah ke sungai. Buangan yang berasal dari kegiatan domestik dan industri yang tersuspensi dalam sungai dapat mempengaruhi penurunan kualitas air pada Sungai Cikapundung. Berbagai upaya dapat dilaksanakan dalam rangka perbaikan kondisi lingkungan Sungai Cikapundung. Salah satu kegiatan yang dapat dilakukan adalah prediksi kualitas airnya melalui pemodelan. Model kualitas untuk sungai yang tercemar limbah domestik pada umumnya menggunakan persamaan BOD dan DO. Studi ini diarahkan untuk mengetahui nilai koefisien laju deoksigenasi aktual air Sungai Cikapundung untuk ruas padat penduduk. Pengambilan sampel dilakukan pada lima titik lokasi yang dianggap dapat mewakili kondisi sungai dengan jumlah kepadatan penduduk. Metode analisis laboratorium yang digunakan dalam perhitungan laju deoksigenasi yaitu menggunakan Metode Winkler dan Metode Slope, sedangkan Rumus Empiris yang digunakan dalam perhitungan laju deoksigenasi menggunakan Rumus Persamaan Hydroscience untuk aliran normal. Hasil perhitungan menunjukkan bahwa nilai rentang laju deoksigenasi (K1) pada Sungai Cikapundung berkisar antara 0,03 hingga 0,24 per hari dan nilai rentang BOD Ultimate (La) berkisar antara 6,42 hingga 15,75 mg/L. Sedangkan untuk nilai rentang laju deoksigenasi (K1) pada Sungai Cikapundung dengan menggunakan rumus empiris berkisar antara 0,50 hingga 0,66 per hari.
Mercedes-Benz returns to hybrid drives
Authors: Rusak Zbigniew 
Published: February 2018

The premiere of the new Citaro with the hybrid drive during this year's Busworld Europe fair is opening a new chapter in the evolution of drive systems of public buses. This time Mercedes-Benz decided to present the completely different attempt at the development of hybrid buses. So far almost all producers have built the hybrid bus, using the conventional drive as the base, however in most cases changes not only were limited to exchanging the components of drive system. Inserting additional electric engine, battery or super condensers and power control system caused, that within design constraints it was necessary to interfere into vehicle superstructure. Of course the assembly of all additional components affected the appreciable increase of the vehicle's price, as well as the increase in mass what has lead to significantly limiting the capacity of the vehicle on average by 10-15 %. Now designers from Mannheim prepared the new construction of the hybrid, being a compromise between the purchase price of the vehicle, price effective costs reduction of its use and the global ecological effect. It was presented in the article.
Better Data From Better Measurements Using Computerized Adaptive Testing
Authors: Weiss David J. 
Published: February 2018

The process of constructing a fixed-length conventional test frequently focuses on maximizing internal consistency reliability by selecting test items that are of average difficulty and high discrimination (a “peaked” test). The effect of constructing such a test, when viewed from the perspective of item response theory, is test scores that are precise for examinees whose trait levels are near the point at which the test is peaked; as examinee trait levels deviate from the mean, the precision of their scores decreases substantially. Results of a small simulation study demonstrate that when peaked tests are “off target” for an examinee, their scores are biased and have spuriously high standard deviations, reflecting substantial amounts of error. These errors can reduce the correlations of these kinds of scores with other variables and adversely affect the results of standard statistical tests. By contrast, scores from adaptive tests are essentially unbiased and have standard deviations that are much closer to true values. Basic concepts of adaptive testing are introduced and fully adaptive computerized tests (CATs) based on IRT are described. Several examples of response records from CATs are discussed to illustrate how CATs function. Some operational issues, including item exposure, content balancing, and enemy items are also briefly discussed. It is concluded that because CAT constructs a unique test for examinee, scores from CATs will be more precise and should provide better data for social science research and applications. DOI:10.2458/azu_jmmss_v2i1_weiss
A Case Study About Why It Can Be Difficult To Test Whether Propensity Score Analysis Works in Field Experiments
Authors: Shadish William R. , Steiner Peter M. , Cook Thomas D. 
Published: February 2018

Peikes, Moreno and Orzol (2008) sensibly caution researchers that propensity score analysis may not lead to valid causal inference in field applications. But at the same time, they made the far stronger claim to have performed an ideal test of whether propensity score matching in quasi-experimental data is capable of approximating the results of a randomized experiment in their dataset, and that this ideal test showed that such matching could not do so. In this article we show that their study does not support that conclusion because it failed to meet a number of basic criteria for an ideal test. By implication, many other purported tests of the effectiveness of propensity score analysis probably also fail to meet these criteria, and are therefore questionable contributions to the literature on the effects of propensity score analysis. DOI:10.2458/azu_jmmss_v3i2_shadish
Pharmacokinetics of buprenorphine after intravenous and oral transmucosal administration in guinea pigs (Cavia porcellus)
Authors: Sadar Miranda J. , Knych Heather K. , Drazenovich Tracy L. , Paul-Murphy Joanne R. 
Published: February 2018

Abstract
OBJECTIVE To determine pharmacokinetics and sedative effects of buprenorphine after IV and oral transmucosal (OTM) administration in guinea pigs.
ANIMALS 14 male guinea pigs (6 adults for preliminary experiment; eight 8 to 11-week-old animals for primary study).
PROCEDURES A preliminary experiment was conducted to determine an appropriate buprenorphine dose. In the primary study, buprenorphine (0.2 mg/kg) was administered IV or OTM, and blood samples were obtained. The pH of the oral cavity was measured before OTM administration. Sedation was scored for 6 hours on a scale of 0 to 3 (0 = no sedation and 3 = heavy sedation). After a 7-day washout period, procedures were repeated in a crossover manner. Plasma buprenorphine concentration was quantified, and data were analyzed with a noncompartmental pharmacokinetic approach.
RESULTS Mean peak plasma buprenorphine concentrations were 46.7 and 2.4 ng/mL after IV and OTM administration, respectively. Mean time to maximum plasma buprenorphine concentration was 1.5 and 71.2 minutes, and mean terminal half-life was 184.9 and 173.0 minutes for IV and OTM administration, respectively. There was a range of sedation effects (0 to 2) for both routes of administration, which resolved within the 6-hour time frame.
CONCLUSIONS AND CLINICAL RELEVANCE On the basis of pharmacokinetic parameters for this study, buprenorphine at 0.2 mg/kg may be administered IV every 7 hours or OTM every 4 hours to maintain a target plasma concentration of 1 ng/mL. Further studies are needed to evaluate administration of multiple doses and sedative effects in guinea pigs with signs of pain.
Effects of dexmedetomidine combined with commonly administered opioids on clinical variables in dogs
Authors: Nishimura Lilian T. , Auckburally Adam , Santilli Juliana , Vieira Beatriz H. B. , Garcia Debora O. , Honsho Cristiane S. , de Mattos-Junior Ewaldo 
Published: February 2018

Abstract
OBJECTIVE To evaluate cardiopulmonary, sedative, and antinociceptive effects of dexmedetomidine combined with commonly administered opioids in dogs.
ANIMALS 8 healthy Beagles.
PROCEDURES Dogs were sedated by IM administration of each of 7 treatments. Treatments comprised dexmedetomidine (0.01 mg/kg; Dex) and the same dose of dexmedetomidine plus butorphanol (0.15 mg/kg; Dex-But), meperidine (5 mg/kg; Dex-Mep), methadone (0.5 mg/kg; Dex-Meth), morphine (0.5 mg/kg; Dex-Mor), nalbuphine (0.5 mg/kg; Dex-Nal), or tramadol (5 mg/kg; Dex-Tram). Cardiorespiratory and arterial blood gas variables and sedative and antinociceptive scores were measured before drug injection (time 0; baseline) and at 15-minute intervals for 120 minutes.
RESULTS Heart rate was reduced at all time points after injection of Dex-But, Dex-Mep, Dex-Meth, and Dex-Mor treatments. There was a significant reduction of mean arterial blood pressure for Dex-But, Dex-Mep, and Dex-Mor treatments at all time points, compared with baseline. There was a significant decrease in respiratory rate, compared with the baseline value, for Dex, Dex-But, Dex-Meth, and Dex-Tram treatments from 15 to 120 minutes. A significant decrease in arterial blood pH was detected from baseline to 120 minutes for all treatments, with differences among Dex, Dex-Mep, and Dex-Mor. Reduction in Pao2 was greater for the Dex-Mep treatment than for the other treatments. The highest sedation scores were detected for Dex-Mep and Dex-Meth treatments. Antinociceptive effects were superior for Dex-But, Dex-Meth, Dex-Mor, and Dex-Nal treatments.
CONCLUSIONS AND CLINICAL RELEVANCE Drug combinations caused similar cardiorespiratory changes, with greater sedative effects for Dex-Mep and Dex-Meth and superior antinociceptive effects for Dex-But, Dex-Meth, Dex-Mor, and Dex-Nal.
Neuropathologic features of the hippocampus and amygdala in cats with familial spontaneous epilepsy
Authors: Yu Yoshihiko , Hasegawa Daisuke , Hamamoto Yuji , Mizoguchi Shunta , Kuwabara Takayuki , Fujiwara-Igarashi Aki , Tsuboi Masaya , Chambers James Ken , Fujita Michio , Uchida Kazuyuki 
Published: February 2018

Abstract
OBJECTIVE To investigate epilepsy-related neuropathologic changes in cats of a familial spontaneous epileptic strain (ie, familial spontaneous epileptic cats [FSECs]).
ANIMALS 6 FSECs, 9 age-matched unrelated healthy control cats, and 2 nonaffected (without clinical seizures)dams and 1 nonaffected sire of FSECs.
PROCEDURES Immunohistochemical analyses were used to evaluate hippocampal sclerosis, amygdaloid sclerosis, mossy fiber sprouting, and granule cell pathological changes. Values were compared between FSECs and control cats.
RESULTS Significantly fewer neurons without gliosis were detected in the third subregion of the cornu ammonis (CA) of the dorsal and ventral aspects of the hippocampus as well as the central nucleus of the amygdala in FSECs versus control cats. Gliosis without neuronal loss was also observed in the CA4 subregion of the ventral aspect of the hippocampus. No changes in mossy fiber sprouting and granule cell pathological changes were detected. Moreover, similar changes were observed in the dams and sire without clinical seizures, although to a lesser extent.
CONCLUSIONS AND CLINICAL RELEVANCE Findings suggested that the lower numbers of neurons in the CA3 subregion of the hippocampus and the central nucleus of the amygdala were endophenotypes of familial spontaneous epilepsy in cats. In contrast to results of other veterinary medicine reports, severe epilepsy-related neuropathologic changes (eg, hippocampal sclerosis, amygdaloid sclerosis, mossy fiber sprouting, and granule cell pathological changes) were not detected in FSECs. Despite the use of a small number of cats with infrequent seizures, these findings contributed new insights on the pathophysiologic mechanisms of genetic-related epilepsy in cats.
PENENTUAN NILAI KONTRAK OPSI TIPE BINARY PADA KOMODITS KAKAO MENGGUNAKAN METODE QUASI MONTE CARLO DENGAN BARISAN BILANGAN ACAK FAURE
Authors: RATNASARI DEWA AYU AGUNG PUTRI , DHARMAWAN KOMANG , NILAKUSMAWATI DESAK PUTU EKA 
Published: February 2018

Contract options are the most important part of an investment strategy. An option is a contract that entitles the owner or holder to sell an asset on a designated maturity date. A binary or asset-or-nothing option is an option in which the option holder will perform or not the option. There are many methods used in determining the option contract value, one of this is the Monte Carlo Quasi method of the Faure random. The purpose of this study is to determine the value of binary type option contract using the Quasi Monte Carlo method of the Faure random and compare with the Monte Carlo method. The results of this study indicate that the option contract calculated by the Monte Carlo Quasi method results in a more fair value. Monte Carlo method simulation 10.000 generate standard error is 0.9316 and the option convergence at 18.9144. While Quasi Monte Carlo simulation 3000 generate standard error is 0.09091 and the option convergence at 18.8203. This show the Quasi Monte Carlo method reaches a faster convergent of Monte Carlo method.
El problema de la cientificidad del Derecho en la concepción de ciencia en la modernidad: Una aproximación al investigar jurídico
Authors: Gómez Caballero Leider 
Published: February 2018

Dentro de la historia de la ciencia ha aparecido la física (physis-estudio de la naturaleza) como uno de los saberes más fecundos y que más rápido ha encontrado el verdadero camino de una ciencia, al decir de Kant (1987), debe la física tan provechosa revolución de su pensamiento a la ocurrencia de buscar (no imaginar) en la naturaleza, conforme a lo que la misma razón ha puesto en ella. En este sentido la física ha sido la ciencia que les ha marcado el derrotero a todas las demás y ha puesto, en diversas ocasiones a replantear saberes externos a ella. El objeto del presente ensayo es describir cómo colateralmente al desarrollo de la física se ha dado también un desarrollo o más bien una transformación del concepto de ciencia y una transformación de aquellos saberes que aspiraron a encuadrar en el nuevo concepto de ciencia; entre estos el derecho. Como corolario de este proceso de intento de formalizar el saber jurídico, surgen muchas escuelas que intentan explicar el investigar jurídico. La experiencia jurídica contemporánea nos muestra que el objeto del estudio jurídico es un objeto que cambia con el tiempo y con las culturas, y la exigencia de un método fundado en la teoría de la interpretación y argumentación surgen como conclusiones-premisas de esta investigación.