bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of the Kuroshio Interannual Variability on the Summertime Precipitation over the East China Sea and Adjacent Area
Authors: Gan Bolan , Kwon Young-Oh , Joyce Terrence M. , Chen Ke , Wu Lixin 
Published: February 2019

AbstractMuch attention has been paid to the climatic impacts of changes in the Kuroshio Extension, instead of the Kuroshio in the East China Sea (ECS). This study, however, reveals the prominent influences of the lateral shift of the Kuroshio at interannual time scale in late spring [April–June (AMJ)] on the sea surface temperature (SST) and precipitation in summer around the ECS, based on high-resolution satellite observations and ERA-Interim. A persistent offshore displacement of the Kuroshio during AMJ can result in cold SST anomalies in the northern ECS and the Japan/East Sea until late summer, which correspondingly causes anomalous cooling of the lower troposphere. Consequently, the anomalous cold SST in the northern ECS acts as a key driver to robustly enhance the precipitation from the Yangtze River delta to Kyushu in early summer (May–August) and over the central ECS in late summer (July–September). In view of the moisture budget analysis, two different physical processes modulated by the lateral shift of the Kuroshio are identified to account for the distinct responses of precipitation in early and late summer, respectively. First, the anomalous cold SST in the northern ECS induced by the Kuroshio offshore shift is likely conducive to the earlier arrival of the mei-yu–baiu front at 30°–32°N and its subsequent slower northward movement, which may prolong the local rainy season, leading to the increased rain belt in early summer. Second, the persistent cold SST anomalies in late summer strengthen the near-surface baroclinicity and the associated strong atmospheric fronts embedded in the extratropical cyclones over the central ECS, which in turn enhances the local rainfall.
Contribution of Different Time-Scale Variations to the Tropical Cyclogenesis Environment over the Northern Tropical Atlantic and Comparison with the Western North Pacific
Authors: Cao Xi , Wu Renguang , Bi Mingyu , Lan Xiaoqing , Dai Yifeng , Zhao Junhu 
Published: February 2019

Abstract
The present study investigates relative contributions of interannual, intraseasonal, and synoptic variations of environmental factors to tropical cyclone (TC) genesis over the northern tropical Atlantic (NTA) during July–October. Analysis shows that convection, lower-level vorticity, and midlevel specific humidity contribute to TC genesis through intraseasonal and synoptic variations with a larger contribution of the latter. The relative contribution of three components of vertical wind shear depends largely on its magnitude. The contribution of sea surface temperature (SST) to TC genesis is mainly due to the interannual component when total SST is above 27.5°C. The barotropic energy for the development of synoptic-scale disturbances comes mainly from climatological mean flows and intraseasonal wind variations. The proportion of contribution between synoptic and intraseasonal variations of convection, relative vorticity, and specific humidity is larger over the eastern NTA than over the western NTA. The barotropic energy conversion has a larger part related to climatological mean flows and intraseasonal wind variations over the eastern and western NTA, respectively. There are notable differences between the NTA and the western North Pacific (WNP). One is that the relative contribution of synoptic variations of convection, relative vorticity, and specific humidity is larger over the NTA, whereas that of intraseasonal variations is larger over the WNP. The other is that the barotropic energy conversion related to climatological mean flows and intraseasonal wind variations is comparable over the NTA, whereas that related to climatological mean flows is larger over the WNP.
Postoperative Tachycardia in Head and Neck Microvascular Free Flap Patients
Authors: Ziegler Andrea , Schneider Alexander , Pittman Amy , Thorpe Eric 
Published: February 2019

ObjectiveThe goal of this study was to determine the incidence of postoperative tachycardia and its predictive value of complications in patients following microvascular free flap surgery in the head and neck.Study DesignRetrospective chart review.SettingSingle tertiary care academic medical center.Subjects and MethodsAll patients who underwent a microvascular free flap of the head and neck by surgeons in the department of otolaryngology from 2013 to 2017 were included in this study.ResultsOf the 344 who patients met inclusion criteria, 40.4% had a maximum heart rate (HR) of the hospitalization over 110 beats per minute (bpm). Patients with a maximum HR greater than 110 bpm were 19 times more likely to experience a composite vascular complication (myocardial infarction, myocardial necrosis, or pulmonary embolism) than patients with a maximum HR <110 bpm (P =. 0063). Patients with a history of chronic kidney disease were also noted to have an increased risk of experiencing a postoperative composite vascular event.ConclusionPostoperative tachycardia is significantly associated with adverse outcomes and should not be dismissed as a normal variant. Identifying patients at an increased risk of having an underlying complication can help guide interpretation, workup, and management of postoperative patients in the head and neck population.
Prohibitin: A hypothetical target for sex-based new therapeutics for metabolic and immune diseases
Authors: Mishra Suresh , Nyomba BL Grégoire 
Published: February 2019

Adipose and immune functions display sex differences and are influenced by sex steroid hormones in health and disease. However, effector molecules that mediate the effects of sex steroids and determine sex differences in adipocytes and immune cells are largely unknown. Sex differences are known to exist in mitochondrial biology, and mitochondria play a crucial role in adipocyte and immune cell functions. In fact, mitochondrial dysregulation is a common finding in a number of diseases that exhibit sex differences. It is, therefore, possible that mitochondria carry out sex-dimorphic functions. Prohibitin, an evolutionarily conserved pleiotropic protein, known to function as a mitochondrial chaperone, has multifaceted relationship with sex steroids and their receptors. New evidence indicates that prohibitin has roles in sex differences in multiple cell and tissue types, including adipocytes, macrophages, and dendritic cells. Transgenic mice overexpressing prohibitin in adipocytes, macrophages, and dendritic cells exhibit sex differences in metabolic and immune phenotypes, mediated through mitochondrial and plasma membrane signaling functions of prohibitin. Thus, the discovery of prohibitin as mediating the effects of sex steroids in multiple cell types has opened a new research direction to study the relationship between sex steroids and mitochondrial proteins and their impact on sex differences in health and disease. In this opinion article, we will provide a personal perspective of the role of prohibitin with cellular compartment- and tissue-specific functions in mediating sex-dimorphic adipose and immune functions. We believe that prohibitin is a potential target for sex-based new therapeutics for metabolic and immune diseases.Impact statementTraditional sex-related biases in research are now obsolete, and it is important to identify the sex of humans, animals, and even cells in research protocols, due to the role of sex as a fundamental facet of biology, predisposition to disease, and response to therapy. Genetic sex, epigenetics and hormonal regulations, generate sex-dimorphisms. Recent investigations acknowledge sex differences in metabolic and immune health as well as chronic diseases. Prohibitin, an evolutionarily conserved molecule, has pleotropic functions in mitochondrial housekeeping, plasma membrane signaling, and nuclear genetic transcription. Studies in adipocytes, macrophages, and transgenic mice indicate that prohibitin interacts with sex steroids and plays a role in mediating sex differences in adipose tissues and immune cell types. Prohibitin may, depending on context, modulate predisposition to chronic metabolic diseases and malignancy and, because of these attributes, could be a target for sex-based therapies of metabolic and immune-related diseases as well as cancer.
Incidence of referred carpal tunnel syndrome and carpal tunnel release surgery in the general population: Increase over time and regional variations
Authors: Tadjerbashi Kamelia , Åkesson Anna , Atroshi Isam 
Published: February 2019

Purpose: To investigate the change in incidence of referred carpal tunnel syndrome (CTS) and carpal tunnel release (CTR) surgery over time and regional variations. Methods: From the nationwide patient registry, we identified all adult individuals who had received first-time CTS diagnosis (International Classification of Diseases, 10th Revision code G560) at secondary or tertiary level and first-time CTR surgery during the period of 9 years. Results: From 2001 through 2009, the incidence (per 100,000 person-years) of CTS diagnosed at secondary or tertiary level increased from 216 to 243 in women and from 95 to 119 in men and of CTR from 117 to 168 in women and from 52 to 78 in men. The mean annual increase in first-time CTR (95% confidence interval) was 5.1% (4.7–5.4) in women and 6.2% (5.6–6.7) in men. The age-standardized 3-year (2007–2009) incidence varied significantly across Sweden’s 21 counties; compared to the county with the lowest incidence of CTR, the incidence rates in the other counties were higher by 6–152% (mean 60%) in women and by 20–182% (mean 85%) in men. The proportion of CTS-diagnosed individuals treated with surgery varied across counties from 53% to 81% in women and from 51% to 77% in men. Conclusion: The incidence of referred CTS and of CTR surgery increased over time in both sexes, with large regional variations found in the incidence rates and in the proportion of individuals treated with surgery.
Biomechanical consequences of first metatarsaophalangeal joint arthrodesis on flexor digitorum longus function: A cadaveric study
Authors: Tan Chin Yik , Bin Mohd Fadil Muhammad Farhan 
Published: February 2019

Background: First metatarsophalangeal joint (MTPJ) arthrodesis is a common treatment modality for hallux rigidus with successful outcomes. However, the effect of arthrodesis on flexor digitorum longus (FDL) is poorly understood. The purpose of this study was to investigate this effect in a biomechanical model. Methods: Ten cadaveric trans-knee amputated specimens were studied. Lesser toe range of motion (ROM) and FDL excursion on simulated FDL contraction were measured in the following three scenarios: (1) before 1st MTPJ arthrodesis, (2) after 1st MTPJ arthrodesis, and (3) after the knot of Henry release. Results: 1st MTPJ arthrodesis reduced both mean lesser toe ROM and FDL excursion. However, there was improvement in these parameters after the knot of Henry release. Conclusions: FDL function was reduced following 1st MTPJ arthrodesis. This effect was contributed by soft tissue connections at the knot of Henry, where FDL crosses flexor hallucis longus (FHL). Therefore, with restriction of FHL movement after 1st MTPJ arthrodesis, FDL movement was also restricted. Clinical Relevance: This result improved our understanding of 1st MTPJ arthrodesis biomechanics and suggested potential benefits of the knot of Henry release in 1st MTPJ arthrodesis to improve FDL function, thereby decreasing the rate of metatarsalgia and other associated problems.
Reproducibility of pelvic sagittal inclination while acquiring radiographs in supine and standing postures
Authors: Uemura Keisuke , Takao Masaki , Otake Yoshito , Koyama Koki , Yokota Futoshi , Hamada Hidetoshi , Sakai Takashi , Sato Yoshinobu , Sugano Nobuhiko 
Published: February 2019

Purpose: Pelvic position on the sagittal plane is usually evaluated with the pelvic sagittal inclination (PSI) angle from a single radiograph. However, the reproducibility of pelvic positioning has not been investigated, and thus, the validity of measuring the PSI from a single film/time point is not understood. Herein, the reproducibility of a patient’s pelvic positions in supine and standing postures was analyzed. Methods: A total of 34 patients who underwent either a pelvic osteotomy or total hip arthroplasty were enrolled in this study. Preoperative radiographs in both supine and standing postures were acquired twice (first X-ray and second X-ray) within 6 months; preoperative computed tomography (CT) images of the full pelvis were also acquired in a supine posture (preop-CT). To eliminate measurement variability, each PSI was automatically measured from radiographs and CT images through the use of CT segmentation and landmark localization followed by intensity-based 2D-3D registration. The absolute difference of PSI among each image was calculated and the intra-class correlation coefficient (ICC) in each posture was also analyzed. Results: The median absolute differences of PSI in the supine posture were 1.3° between the first and second X-rays, 1.2° between the first X-ray and preop-CT, and 1.3° between the second X-ray and preop-CT. The median absolute difference of PSI in the standing posture was 1.5°. The ICC was 0.965 (95% CI: 0.939–0.981) in supine and 0.977 (95% CI: 0.954–0.988) during standing. Conclusions: Pelvic positions in supine and standing postures are reproducible. Thus, measuring the PSI from a single radiograph is reliable.
Vitamin D receptor–mediated skewed differentiation of macrophages initiates myelofibrosis and subsequent osteosclerosis
Authors: Wakahashi Kanako , Minagawa Kentaro , Kawano Yuko , Kawano Hiroki , Suzuki Tomohide , Ishii Shinichi , Sada Akiko , Asada Noboru , Sato Mari , Kato Shigeaki , Shide Kotaro , Shimoda Kazuya , Matsui Toshimitsu , Katayama Yoshio 
Published: February 2019

AbstractMyelofibrosis in myeloproliferative neoplasms (MPNs) with mutations such as JAK2V617F is an unfavorable sign for uncontrollable disease progression in the clinic and is complicated with osteosclerosis whose pathogenesis is largely unknown. Because several studies have revealed that macrophages are an indispensable supporter for bone-forming osteoblasts, we speculated that macrophages might play a significant role in the proliferation of collagen-producing myofibroblasts in marrow fibrotic tissues. Here, we show that myelofibrosis critically depends on macrophages whose differentiation is skewed by vitamin D receptor (VDR) signaling. In our novel myelofibrosis model established by transplantation of VDR+/+ hematopoietic stem/progenitor cells into VDR−/− mice, donor-derived F4/80+ macrophages proliferated together with recipient-derived α-smooth muscle actin–positive myofibroblasts, both of which comprised fibrotic tissues with an indistinguishable spindle-shaped morphology. Interfering VDR signals, such as low vitamin D diet and VDR deficiency in donor cells as well as macrophage depletion prevented myelofibrosis in this model. These interventions also ameliorated myelofibrosis in JAK2V617F-driven murine MPNs likely in a transforming growth factor-β1– or megakaryocyte-independent manner. These results suggest that VDR and macrophages may be novel therapeutic targets for MPNs with myelofibrosis.
Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects
Authors: Hsu Amy P. , Donkó Agnes , Arrington Megan E. , Swamydas Muthulekha , Fink Danielle , Das Arundhoti , Escobedo Omar , Bonagura Vincent , Szabolcs Paul , Steinberg Harry N. , Bergerson Jenna , Skoskiewicz Amanda , Makhija Melanie , Davis Joie , Foruraghi Ladan , Palmer Cindy , Fuleihan Ramsay L. , Church Joseph A. , Bhandoola Avinash , Lionakis Michail S. , Campbell Sharon , Leto Thomas L. , Kuhns Douglas B. , Holland Steven M. 
Published: February 2019

Abstract
Ras-related C3 botulinum toxin substrate 2 (RAC2), through interactions with reduced NAD phosphate oxidase component p67phox, activates neutrophil superoxide production, whereas interactions with p21-activated kinase are necessary for fMLF-induced actin remodeling. We identified 3 patients with de novo RAC2[E62K] mutations resulting in severe T- and B-cell lymphopenia, myeloid dysfunction, and recurrent respiratory infections. Neutrophils from RAC2[E62K] patients exhibited excessive superoxide production, impaired fMLF-directed chemotaxis, and abnormal macropinocytosis. Cell lines transfected with RAC2[E62K] displayed characteristics of active guanosine triphosphate (GTP)–bound RAC2 including enhanced superoxide production and increased membrane ruffling. Biochemical studies demonstrated that RAC2[E62K] retains intrinsic GTP hydrolysis; however, GTPase-activating protein failed to accelerate hydrolysis resulting in prolonged active GTP-bound RAC2. Rac2+/E62K mice phenocopy the T- and B-cell lymphopenia, increased neutrophil F-actin, and excessive superoxide production seen in patients. This gain-of-function mutation highlights a specific, nonredundant role for RAC2 in hematopoietic cells that discriminates RAC2 from the related, ubiquitous RAC1.
Genome-wide promoter methylation of hairy cell leukemia
Authors: Arribas Alberto J. , Rinaldi Andrea , Chiodin Giorgia , Kwee Ivo , Mensah Afua Adjeiwaa , Cascione Luciano , Rossi Davide , Kanduri Meena , Rosenquist Richard , Zucca Emanuele , Johnson Peter W. , Gaidano Gianluca , Oakes Christopher C. , Bertoni Francesco , Forconi Francesco 
Published: February 2019

AbstractClassic hairy cell leukemia (HCL) is a tumor of mature clonal B cells with unique genetic, morphologic, and phenotypic features. DNA methylation profiling has provided a new tier of investigation to gain insight into the origin and behavior of B-cell malignancies; however, the methylation profile of HCL has not been specifically investigated. DNA methylation profiling was analyzed with the Infinium HumanMethylation27 array in 41 mature B-cell tumors, including 11 HCL, 7 splenic marginal zone lymphomas (SMZLs), and chronic lymphocytic leukemia with an unmutated (n = 7) or mutated (n = 6) immunoglobulin gene heavy chain variable (IGHV) region or using IGHV3-21 (n = 10). Methylation profiles of nontumor B-cell subsets and gene expression profiling data were obtained from public databases. HCL had a methylation signature distinct from each B-cell tumor entity, including the closest entity, SMZL. Comparison with normal B-cell subsets revealed the strongest similarity with postgerminal center (GC) B cells and a clear separation from pre-GC and GC cellular programs. Comparison of the integrated analysis with post-GC B cells revealed significant hypomethylation and overexpression of BCR–TLR–NF-κB and BRAF-MAPK signaling pathways and cell adhesion, as well as hypermethylation and underexpression of cell-differentiation markers and methylated genes in cancer, suggesting regulation of the transformed hairy cells through specific components of the B-cell receptor and the BRAF signaling pathways. Our data identify a specific methylation profile of HCL, which may help to distinguish it from other mature B-cell tumors.
PTCy-based haploidentical vs matched related or unrelated donor reduced-intensity conditioning transplant for DLBCL
Authors: Dreger Peter , Sureda Anna , Ahn Kwang Woo , Eapen Mary , Litovich Carlos , Finel Herve , Boumendil Ariane , Gopal Ajay , Herrera Alex F. , Schmid Christoph , Diez-Martin José Luis , Fuchs Ephraim , Bolaños-Meade Javier , Gooptu Mahasweta , Al Malki Monzr M. , Castagna Luca , Ciurea Stefan O. , Dominietto Alida , Blaise Didier , Ciceri Fabio , Tischer Johanna , Corradini Paolo , Montoto Silvia , Robinson Stephen , Gülbas Zafer , Hamadani Mehdi 
Published: February 2019

Abstract
This study retrospectively compared long-term outcomes of nonmyeloablative/reduced intensity conditioning (NMC/RIC) allogeneic hematopoietic cell transplantation (allo-HCT) from a haploidentical family donor (haplo-HCT) using posttransplant cyclophosphamide (PTCy) with those of matched sibling donor (MSD) and matched unrelated donor (MUD) with or without T-cell depletion (TCD+/TCD−) in patients with relapsed diffuse large B-cell lymphoma (DLBCL). Adult patients with DLBCL who had undergone their first NMC/RIC allo-HCT between 2008 and 2015 were included. Recipients of haplo-HCT were limited to those receiving graft-versus-host disease (GVHD) prophylaxis with PTCy. GVHD prophylaxis in MSD was limited to calcineurin inhibitor (CNI)–based approaches without in vivo TCD, while MUD recipients received CNI-based prophylaxis with or without TCD. Outcome analyses for overall survival (OS) and progression-free survival (PFS), nonrelapse mortality (NRM), and disease relapse/progression were calculated. A total of 1438 patients (haplo, 132; MSD, 525; MUD TCD+, 403; and MUD TCD−, 378) were included. Patients with haplo donors were significantly older, had a better performance status and had more frequently received total body irradiation-based conditioning regimens and bone marrow grafts than MSD and MUD TCD+ or TCD−. 3-year OS, PFS, NRM and relapse/progression incidence after haplo-HCT was 46%, 38%, 22%, and 41%, respectively, and not significantly different from outcomes of matched donor transplants on multivariate analyses. Haplo-HCT was associated with a lower cumulative incidence of chronic GVHD compared with MSD, MUD TCD+/TCD−. NMC/RIC haplo-HCT with PTCy seems to be a valuable alternative for patients with DLBCL considered for allo-HCT but lacking a matched donor.
Feasibility and acceptability of suicide prevention therapy on acute psychiatric wards: randomised controlled trial
Authors: Haddock Gillian , Pratt Daniel , Gooding Patricia A. , Peters Sarah , Emsley Richard , Evans Emma , Kelly James , Huggett Charlotte , Munro Ailsa , Harris Kamelia , Davies Linda , Awenat Yvonne 
Published: February 2019

BackgroundSuicidal behaviour is common in acute psychiatric wards resulting in distress, and burden for patients, carers and society. Although psychological therapies for suicidal behaviour are effective in out-patient settings, there is little research on their effectiveness for in-patients who are suicidal.AimsOur primary objective was to determine whether cognitive–behavioural suicide prevention therapy (CBSP) was feasible and acceptable, compared with treatment as usual (TAU) for in-patients who are suicidal. Secondary aims were to assess the impact of CBSP on suicidal thinking, behaviours, functioning, quality of life, service use, cost-effectiveness and psychological factors associated with suicide.MethodA single-blind pilot randomised controlled trial comparing TAU to TAU plus CBSP in in-patients in acute psychiatric wards who are suicidal (the Inpatient Suicide Intervention and Therapy Evaluation (INSITE) trial, trial registration: ISRCTN17890126). The intervention consisted of TAU plus up to 20 CBSP sessions, over 6 months continuing in the community following discharge. Participants were assessed at baseline and at 6 weeks and 6 months post-baseline.ResultsA total of 51 individuals were randomised (27 to TAU, 24 to TAU plus CBSP) of whom 37 were followed up at 6 months (19 in TAU, 18 in TAU plus CBSP). Engagement, attendance, safety and user feedback indicated that the addition of CBSP to TAU for in-patients who are acutely suicidal was feasible and acceptable while on in-patient wards and following discharge. Economic analysis suggests the intervention could be cost-effective.DiscussionPsychological therapy can be delivered safely to patients who are suicidal although modifications are required for this setting. Findings indicate a larger, definitive trial should be conducted.Declaration of interestThe trial was hosted by Greater Manchester Mental health NHS Trust (formerly, Manchester Mental Health and Social Care NHS Trust). The authors are affiliated to the University of Manchester, Greater Manchester Mental Health Foundation Trust, Lancashire Care NHS Foundation trust and the Manchester Academic Health Sciences Centre. Y.A. is a trustee for a North-West England branch of the charity Mind.