bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Views and Values Placed on the Uterus
Authors: Chang Olivia H. , Huynh Ashley , Ringel Nancy , Hudson Patricia L. , Halder Gabriela E. , Winkleman William D. , Ton Jessica , Davidson Emily R.W. , Meriwether Kate 
Published: December 2024

OBJECTIVE:
To understand women's views of and values placed on the uterus.

METHODS:
This was a multicenter, mixed methods, prospective cohort study at seven medical centers across the United States involved with the Society of Gynecologic Surgeons' Collaborative Research in Pelvic Surgery Consortium network. Adults with a uterus and a benign gynecologic condition with no intention for pregnancy were recruited. Chart review and patient questionnaires, including the validated VALUS (Value of Uterus) instrument, were completed. Semi-structured audio interviews were performed in a subset of participants to identify themes associated with values of the uterus. Interview transcripts were thematically analyzed using the grounded theory approach until saturation was reached.

RESULTS:
Qualitative data were collected from 40 participants; 36 (90.0%) completed the VALUS questionnaire, and 20 (50.0%) completed semi-structured interviews. The median age was 51 years, and patients mostly identified as White race (75.0%). Participants' gynecologic conditions included urinary incontinence (57.5%), pelvic pain (42.5%), pelvic organ prolapse (40.0%), and various other gynecologic conditions. Based on the VALUS score, 55.6% (20/36) placed a high value on the uterus and 44.4% (16/36) placed a low value on the uterus. When asked about the value of the uterus, some participants viewed it as an organ for reproduction and fertility and their personhood or womanhood, whereas others thought of it as an organ of no value. Recurring themes around considerations before a hysterectomy procedure included a lack of knowledge regarding the physiologic role of the uterus beyond reproduction, the desire for more knowledge to make informed decisions and to understand the purpose of the hysterectomy procedure and alternatives.

CONCLUSION:
In this multicenter, mixed methods analysis, more than half the participants placed a high value on the uterus. The values of the uterus included fertility, personhood, and womanhood, which often was described as changing with patient's age or life circumstances. Our findings highlight the need to include the patient's values of the uterus to foster person-centered care in the treatment of gynecologic disorders when uterine preservation is an option.
Tuberous Sclerosis Complex Demonstrated on 18F-FDG PET/CT
Authors: Kesim Selin , Filizoglu Nuh 
Published: December 2024

Abstract
Tuberous sclerosis complex is a rare neurocutaneous genetic disorder that can affect multiple organ systems including the skin, eyes, brain, kidneys, heart, and lungs. Herein, we report 18F-FDG PET/CT findings of brain and skin lesions, bilateral renal angiomyolipomas, and pulmonary lymphangioleiomyomatosis in a patient with tuberous sclerosis complex.
Investigating the Functional Role of the DI-DII Linker in Nav1.5 Channel Function
Authors: Wagner Emily , Marras Martina , Kumar Shashi , Kelley Jacob , Ruff Kiersten , Silva Jonathan 
Published: December 2024

AbstractThe cardiac voltage-gated sodium channel, Nav1.5 initiates the cardiac action potential. Its dysfunction can lead to dangerous arrhythmias, sudden cardiac arrest, and death. The functional Nav1.5 core consists of four homologous repeats (I, II, III, and IV), each formed from a voltage sensing and a pore domain. The channel also contains three cytoplasmic linkers (I-II, II-III, and III-IV). While Nav1.5 structures have been published, the I-II and II-III linkers have remained absent, are predicted to be disordered, and their functional role is not well understood.We divided the I-II linker into eight regions ranging in size from 32 to 52 residues, chosen based on their distinct properties. Since these regions had unique sequence properties, we hypothesized that they may have distinct effects on channel function. We tested this hypothesis with experiments with individual Nav1.5 constructs with each region deleted. These deletions had small effects on channel gating, though two (430 – 457del and 556 – 607del) reduced peak current. Phylogenetic analysis of the I-II linker revealed five prolines (P627, P628, P637, P640, P648) that were conserved in mammals but absent from theXenopussequence. We created mutant channels, where these were replaced with their Xenopus counterparts. The only mutation that had a significant effect on channel gating was P627S, which depolarized channel activation (10.13 +/- 2.28 mV). Neither a phosphosilent (P627A) nor a phosphomimetic (P627E) mutation had a significant effect, suggesting that either phosphorylation or another specific serine property is required.Since deletion of large regions had little effect on channel gating while a point mutation had a conspicuous impact, the I-II linker role may be to facilitate interactions with other proteins. Variants may have a larger impact if they create or disrupt these interactions, which may be key in evaluating pathogenicity of variants.
Premenstrual disorders and risk of sick leave and unemployment: a prospective cohort study of 15,857 women in Sweden
Authors: Yu Hang , Yang Yihui , Hysaj Elgeta , Nevriana Alicia , Hägg Sara , Valdimarsdóttir Unnur Anna , Bertone-Johnson Elizabeth , Lu Donghao 
Published: December 2024

AbstractImportancePremenstrual disorders (PMDs) are prevalent and significantly impair women’s quality of life. Yet, the long-term impact on work capacity is not well understood.ObjectiveTo prospectively examine the association between PMDs and work incapacity, including sick leave and unemployment.Setting, Design and ParticipantsA prospective cohort study of 15,857 women aged 15-60 years and employed at baseline in the LifeGene Study with linkage to population and health registers in Sweden.ExposurePMDs were identified via register-based clinical diagnoses and symptom questionnaires.Main Outcomes and MeasuresWe extracted information on sick leave and unemployment status from national registers. We used Poisson regression to estimate incidence rate ratios (IRRs) of sick leave and unemployment comparing women with PMDs to those without.ResultsIn total, 2,585 (16.30%) women (mean age 32.52 years) reported symptom burden indicative of probable a PMD. With a median follow-up of 9.17 years, 6,741 (42.51%) and 1,485 (9.36%) women were exposed to at least one sick leave and unemployment during follow-up, respectively. Compared to women without PMDs, those with PMDs had 40% and 27% higher risks of sick leave (fully adjusted-IRR 1.40, 95% CI 1.31-1.49) and unemployment (IRR 1.27, 95% CI 1.10-1.46), respectively. The association was particularly stronger for long-term sick leave (≥ 90 days) (IRR 1.69, 95% CI 1.50-1.91), and sick leave due to depression (IRR 1.41, 95% CI 1.27-1.56). In addition, comparable associations for sick leave and unemployment were yielded, when comparing women with and without a history of depression/anxiety.ConclusionsEmployed women with PMDs are at increased risk of sick leave and unemployment, underscoring the potential long-term health and socioeconomic consequences of this prevalent condition. Improved clinical management of comorbidities and workplace policies are needed to support women affected by PMDs.
Mechanical communication through the ECM is frequency-dependent due to cell sensitivity to mechanical signal shape
Authors: Nitsan Ido , Drori Stavit , Tzlil Shelly 
Published: December 2024

AbstractCells communicate mechanically by sensing and responding to mechanical deformations generated by their neighbors in the extracellular matrix (ECM). Cell-generated deformations propagates through the ECM and therefore mechanical communication depends on the mechanical properties of the matrix. By directly measuring the mechanical coupling between a cardiac cell and an artificial ‘mechanical cell’ and monitoring the dependence of beat-to-beat variability on mechanical coupling, we can quantify the sensitivity of cardiac cells to mechanical signals. Here we show that due to the dynamic viscoelastic properties of collagen hydrogels (a major component of the cardiac ECM), the shape of the mechanical signal changes in a frequency-dependent manner as it propagates through the gel, resulting in mechanical communication that depends on beating frequency. Moreover, we show that cardiac cell’s sensitivity to the shape of the mechanical signal results from its responsiveness to the loading rate, with an optimal loading rate for efficient mechanical communication. The dependence of signal shape on ECM viscoelasticity and the existence of an optimal loading rate suggest that there may be ideal viscoelastic properties for mechanical communication between cardiac cells.
Multi-omics analysis of the mechanism of alfalfa and wheat-induced rumen flatulence in Xizang sheep
Authors: Song Tianzeng , Wu Jing , Zhang Xiaoming , Khan Ayesha , Cui Jianzhao , Shahzad Khuram , Wang Gaofu , Zhaxi Yangzong , Shi Mingyan , Zhao Wangsheng , Jiang Xunping , Li Long , Liu Guiqiong 
Published: December 2024

AbstractThis study induced a rumen flatulence model in Xizang sheep using alfalfa (HRF) and wheat grass (MRF) to explore related mechanisms. The pH of HRF and MRF groups was lower than the natural grass group. SCFA concentrations varied in different groups. Microbial analysis showed HRF and MRF groups had lower alpha and beta diversity and different compositions. Transcriptome analysis found different numbers of differentially expressed genes in each group. Spearman’s correlation analysis indicated Butyrivibrio was related to GLRX and DUOX2, and Quinella to several genes.
Molecular Insights into the Regulation of GNPTAB by TMEM251
Authors: Yang Xi , Doray Balraj , Venkatarangan Varsha , Jennings Benjamin C. , Henn Danielle , Liang Jiaxuan , Zhao Haikun , Zhang Weichao , Zhang Bokai , Yu Linchen , Chen Liang , Kornfeld Stuart , Li Ming 
Published: December 2024

AbstractIn vertebrates, newly synthesized lysosomal enzymes traffick to lysosomes through the mannose-6-phosphate (M6P) pathway. The Golgi membrane protein TMEM251 was recently discovered to regulate lysosome biogenesis by controlling the level of GlcNAc-1-phosphotransferase (GNPT). However, its precise function remained unclear. In this study, we demonstrate that TMEM251 is a two-transmembrane protein indispensable for GNPT stability, cleavage by Site-1-Protease (S1P), and enzymatic activity. We reconcile conflicting models by showing that TMEM251 enhances GNPT cleavage and prevents its mislocalization to lysosomes for degradation. We further establish that TMEM251 achieves this by interacting with GOLPH3 and retromer complexes to anchor the TMEM251-GNPT complex at the Golgi. Alanine mutagenesis identified F4XXR7motif in TMEM251’s N-tail for GOLPH3 binding. Together, our findings uncover TMEM251’s multi-faceted role in stabilizing GNPT, retaining it at the Golgi, and ensuring the fidelity of the M6P pathway, thereby providing insights into its molecular function.
Terms of trade, ecologically unequal exchange and
environmental problems in developing economies
Authors: Feng Zhixuan , Liu Fengyi 
Published: December 2024

Purpose
Utilizing the Marxist theory of unequal exchange to explain the terms of
trade between nations, this paper elucidates one possible mechanism that
gives rise to ecologically unequal exchange between developed and developing
economies.

Design/methodology/approach
We propose a two-sector linear production model and demonstrate that a
decrease in the organic composition of capital and an increase in the rate
of surplus value in a sector will lead to a relative price decrease and
value transfer out of that particular sector, as well as increasing the
environmental costs of trade. Furthermore, we measure the levels of unequal
exchange (value transfer) and ecologically unequal exchange of 40 economies
and empirically validate their relationship.

Findings
The findings suggest that an important cause of the ecologically unequal
exchange is the value transfer between economies caused by the international
division of labor and real wage disparities. The inequality in international
trade is a significant factor contributing to the gap in the ecological
environment level between developed and developing economies.

Originality/value
By introducing the theory of unequal exchange or value transfer into the
analysis of ecological unequal exchange, we provide a mathematical framework
for analyzing ecological unequal exchange and a method for calculating the
scale of ecological unequal exchange and value transfer, thereby enhancing
the theoretical depth and practical significance of the ecological unequal
exchange theory.
BRTPillar: boosting real-time 3D object detection based point cloud and RGB image fusion in autonomous driving
Authors: Zhang Zhitian , Zhao Hongdong , Zhao Yazhou , Chen Dan , Zhang Ke , Li Yanqi 
Published: December 2024

PurposeIn autonomous driving, the inherent sparsity of point clouds often limits the performance of object detection, while existing multimodal architectures struggle to meet the real-time requirements for 3D object detection. Therefore, the main purpose of this paper is to significantly enhance the detection performance of objects, especially the recognition capability for small-sized objects and to address the issue of slow inference speed. This will improve the safety of autonomous driving systems and provide feasibility for devices with limited computing power to achieve autonomous driving.Design/methodology/approachBRTPillar first adopts an element-based method to fuse image and point cloud features. Secondly, a local-global feature interaction method based on an efficient additive attention mechanism was designed to extract multi-scale contextual information. Finally, an enhanced multi-scale feature fusion method was proposed by introducing adaptive spatial and channel interaction attention mechanisms, thereby improving the learning of fine-grained features.FindingsExtensive experiments were conducted on the KITTI dataset. The results showed that compared with the benchmark model, the accuracy of cars, pedestrians and cyclists on the 3D object box improved by 3.05, 9.01 and 22.65%, respectively; the accuracy in the bird’s-eye view has increased by 2.98, 10.77 and 21.14%, respectively. Meanwhile, the running speed of BRTPillar can reach 40.27 Hz, meeting the real-time detection needs of autonomous driving.Originality/valueThis paper proposes a boosting multimodal real-time 3D object detection method called BRTPillar, which achieves accurate location in many scenarios, especially for complex scenes with many small objects, while also achieving real-time inference speed.
Paying for individual performance and job satisfaction: the role of self-concern and other-orientation
Authors: Chen Long , Yao Feisi 
Published: December 2024

PurposePrevious studies have yielded mixed results regarding the influence of pay for individual performance on job satisfaction. This study aims to investigate how and when pay for individual performance impacts employee job satisfaction.Design/methodology/approachIn light of self-determination theory, this study examines the moderating effect of self-concern and other-orientation on the association between pay for individual performance and employee job satisfaction through the mediation of intrinsic motivation. This study tests the proposed hypotheses using a two-wave survey study (n = 701) and an online experiment study (n = 440).FindingsThe findings reveal that pay for individual performance has an indirect positive (negative) effect on employee job satisfaction through intrinsic motivation among those with high self-concern or low other-orientation (high other-orientation).Originality/valueThese results underscore the substantial role of individual differences in prosocial orientations when explaining how pay systems shape employees’ attitudes.
Strengthening the body and mind: a Chinese martial arts school outreach program in post-COVID Hong Kong
Authors: Lui Kylie Chiu Yee 
Published: December 2024

Purpose
The COVID-19 pandemic had amplified feelings of isolation and alienation, particularly among school-aged children. The pandemic-related social distancing policies had led to a marked decline in students’ physical and social well-being, potentially fostering a sense of apathy among them. Upon returning to the “normal” in late 2022, a Chinese martial arts Outreach Program was launched in over 50 schools in Hong Kong, involving the entire student body and teachers at each school. This paper aims to explore the potential role of sports in enhancing student well-being in post-COVID times and as a societal response to the evolving sociopolitical landscape in Hong Kong, using the program as a case study.

Design/methodology/approach
Using ethnographic immersion, participant observation and semi-structured interviews, the study examines how the program sought to overcome the challenges students were facing during the pandemic through Chinese martial arts instruction and the teaching of traditional Chinese values.

Findings
The findings of this study reveal that the objectives of the Chinese martial arts Outreach Program not only centered on students’ immediate personal well-being but also entailed broader goals of advancing national education. The program’s design, which integrated sports and national education, emerged as a response to the pandemic and the sociopolitical transformations in Hong Kong, particularly following the implementation of the National Security Law.

Originality/value
The findings will deepen the understanding of how sport has been politicized as a means to respond to the societal changes in Hong Kong, especially after the pandemic.
Measuring climate change from an actuarial perspective: A survey of insurance applications
Authors: Zhou Nan , Vilar‐Zanón José Luis , Garrido Jose , Heras‐Martínez Antonio José 
Published: December 2024

AbstractClimate change refers to persistent alterations to global Earth's climate, such as a rise in global temperatures, which have reached unprecedented peaks in recent years. At the same time, global mean ocean‐and‐sea levels are on an upward trajectory. These climatic shifts significantly influence the frequency, intensity, and duration of extreme weather events, such as heatwaves, heavy precipitations, droughts, floods, and tropical cyclones, which represent substantial risks and challenges for the insurance industry. This paper delves into the profound impact of climate change on the insurance sector, with a particular focus on the agriculture, property, health, and life insurance industries. Our scientific approach consists in measuring climate change through an index composed of a basket of climate and weather‐related extremes, such as the Actuarial Climate Index™ (ACI) defined in and for North America, and its European counterparts, the Iberian ACI (IACI) and French ACI (FACI) climate indices. We discuss how these indices help quantify the impact of climate change on the balance sheets of insurance companies and, therefore, its impact on the sustainability of the insurance business. The paper underscores the pressing need for the insurance industry to adapt and strategically plan for the increasing risks associated with climate change.
Being born extremely preterm with low‐grade intraventricular haemorrhage had no impact on brain volumes or neurodevelopment in later childhood
Authors: Broström Lina , de Gamarra‐Oca Lexuri Fernández , Kvanta Hedvig , Örtqvist Maria , Padilla Nelly , Ådén Ulrika 
Published: December 2024

AbstractAimOur aim was to investigate the impact that low‐grade intraventricular haemorrhage (IVH) had on neonatal morbidities, brain volumes and neurodevelopmental outcomes in children born extremely preterm (EPT) and compare them with children born EPT without low‐grade IVH.MethodsThis prospective cohort study was carried out in Stockholm, Sweden. It focused on 103 children born EPT from 2004 to 2007, at less than 27 weeks of gestation, without major brain injuries. The group with low‐grade IVH, defined as grades I–II, were compared with children born EPT without IVH. Around half (45%) underwent MRI scans at 10 years of age and 55% had neurodevelopmental assessments at 12 years.ResultsThe low‐grade IVH group was sicker during the neonatal period than the children born EPT without IVH. They had lower gestational ages at birth, more days on mechanical ventilation, a higher incidence of necrotising enterocolitis and were more likely to need surgical ligation of patent ductus arteriosus. However, they did not have significantly smaller brain volumes at 10 years of age or worse neurodevelopmental outcomes at 12 years of age.ConclusionBrain volumes or neurodevelopment were not affected in children born EPT with low‐grade IVH, compared to children born EPT without IVH.
Micrognathia and cleft palate as a cause of obstructive sleep apnoea in infants
Authors: Kirjavainen Turkka , Vuola Pia , Suominen Janne , Saarikko Anne 
Published: December 2024

AbstractAimObstructive sleep apnoea (OSA) is common in Robin sequence (RS). We investigated the significance of micrognathia, cleft palate and sleep positioning on OSA in infants.MethodsWe analysed our 13‐year national reference centre polysomnography (PSG) dataset. PSG was performed as daytime recordings (97%) in the supine‐, side‐ and prone sleeping position at the median age of 5 weeks (interquartile range 3–8 weeks).ResultsOur study included 113 infants with RS and cleft palate, 10 infants with RS but intact palate and 32 infants with cleft palate without micrognathia. The degree of OSA in infants with cleft palate without micrognathia was less severe than in infants with RS in terms of obstructive events (median OAHI 4 vs. 32 h−1, respectively), SpO2 desaturations (ODI≥3OAH 0.4 vs. 3 h−1), transcutaneous pCO2 levels (TcCO2P95, 41 vs. 46 mmHg) (p < 0.0001) and work of breathing (p = 0.01). In the RS group, OSA was sleep‐position dependent, with fewer obstructive events apparent in the side (18 vs. 24 h−1, p = 0.005) and prone (39 vs. 27 h−1, p = 0.003) sleeping positions than when supine.ConclusionsThe degree of OSA in RS infants is more dependent on micrognathia than on cleft palate.
Enabling Inclusion: An Analysis of Positive and Negative Outcomes of Discretionary Work Arrangements for Employees With Disabilities
Authors: Booth Jonathan E. , Lup Daniela 
Published: December 2024

ABSTRACTWhile it is well‐known that employees with disabilities have significantly more negative work experiences compared to other employees, research geared towards understanding how employers could improve some of these experiences is still underdeveloped. To advance this research agenda, this study investigates links between five distinct types of discretionary arrangements (work discretion, scheduling discretion, part‐timing, homeworking and pay for individual performance), and outcomes related to work experiences and the wellbeing of employees with disabilities (job satisfaction, perception of fairness, recognition, motivation, engagement, work stress and work‐life interference). To explore these links, we use data from the European Working Conditions Survey (2015). We find that not all work arrangements that increase discretion at the workplace have a positive impact on employees with disabilities and that some can be especially detrimental. By unpacking the multiple ways in which various types of discretion at the workplace affect employees with disabilities, this study not only makes a theoretical contribution but also provides employers who aim to improve the working experiences of employees with disabilities with some empirical evidence to help them take more inclusive actions.