bluuebunny/crossref_metadata_2025_split huggingface dataset:
First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study
Authors: Correa Paula J. , Venegas Pia , Palmeiro Yasna , Albers Daniela , Rice Gregory , Roa Jaime , Cortez Jorge , Monckeberg Max , Schepeler Manuel , Osorio Eduardo , Illanes Sebastian E. 
Published: September 2018

Abstract

Objectives
To evaluate the first trimester maternal biomarkers for early pregnancy prediction of gestational diabetes mellitus (GDM).

Methods
The study was a case-control study of healthy women with singleton pregnancies at the first trimester carried out at the Obstetrics and Gynecology Unit, Clinica Davila, Santiago, Chile. After obtaining informed consent, peripheral blood samples of pregnant women under 14 weeks of gestation were collected. At 24–28 weeks of pregnancy, women were classified as GDM (n=16) or controls (n=80) based on the results of a 75-g oral glucose tolerance test (OGTT). In all women, we measured concentrations of fasting blood glucose, insulin, glycated hemoglobin, uric acid, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), alkaline phosphatase (AP), sex hormone-binding globulin (SHBG), adiponectin, tissue plasminogen activator (t-PA), leptin and placental growth factor (PGF).

Results
The GDM group displayed an increased median concentration of cholesterol (P=0.04), triglycerides (P=0.003), insulin (P=0.003), t-PA (P=0.0088) and homeostatic model assessment (HOMA) (P=0.003) and an increased mean concentration of LDL (P=0.009) when compared to the control group. The receiver operating characteristic (ROC) curve for significant variables achieved an area under the curve (AUC) of 0.870, a sensitivity of 81.4% and a specificity of 80.0%. The OGTT was positive for GDM according to the IADPSG (International Diabetes in Pregnancy Study Group) criteria.

Conclusion
Women who subsequently developed GDM showed higher levels of blood-borne biomarkers during the first trimester, compared to women who did not develop GDM. These data warrant validation in a larger cohort.
The Cognitive Aspect of Christian Faith and Non-doxastic Propositional Attitudes
Authors: Eklund Dan-Johan Sebastian 
Published: September 2018

Summary
In the recent discussion, several authors have argued for the claim that propositional faith need not be doxastic, but also can be “non-doxastic”. Notable proponents of this view are William Alston, Robert Audi, Daniel Howard-Snyder, and J. L. Schellenberg. In this paper, I focus on Christian faith and consider whether its cognitive aspect can be understood solely in terms of Alston’s and others’ non-doxastic accounts. I argue for a negative answer. In my view, the cognitive aspect of Christian faith calls for, as a minimum, “a sub-doxastic attitude”. As there is no shared terminology on this topic, a proportion of this paper deals with conceptual clarifications.
Design Discourse: A Way Forward for Theistic Evolutionism?
Authors: Kojonen Erkki Vesa Rope 
Published: September 2018

Summary
It is usually supposed that biological design arguments (where biological complex order is seen as evidence of a Creator) are made obsolete by Darwinian evolutionary theory. However, philosopher Alvin Plantinga and others have defended the continued possibility of a rational “design discourse”, in which biological order is taken as a sign of God’s purposeful action. In this article, I consider two objections to design discourse: (1) a theological objection to biological design based on the problem of natural evil, and (2) the evolutionary objection, according to which evolutionary theory removes the justification for any biological design perception. Whereas Plantinga’s own response utilizes the arguments of the Intelligent Design movement, I argue in favor of utilizing “design discourse” as part of a theistic evolutionist view.
A novel database of bio-effects from non-ionizing radiation
Authors: Leach Victor , Weller Steven , Redmayne Mary 
Published: September 2018

Abstract
A significant amount of electromagnetic field/electromagnetic radiation (EMF/EMR) research is available that examines biological and disease associated endpoints. The quantity, variety and changing parameters in the available research can be challenging when undertaking a literature review, meta-analysis, preparing a study design, building reference lists or comparing findings between relevant scientific papers. The Oceania Radiofrequency Scientific Advisory Association (ORSAA) has created a comprehensive, non-biased, multi-categorized, searchable database of papers on non-ionizing EMF/EMR to help address these challenges. It is regularly added to, freely accessible online and designed to allow data to be easily retrieved, sorted and analyzed. This paper demonstrates the content and search flexibility of the ORSAA database. Demonstration searches are presented by Effect/No Effect; frequency-band/s; in vitro; in vivo; biological effects; study type; and funding source. As of the 15th September 2017, the clear majority of 2653 papers captured in the database examine outcomes in the 300 MHz–3 GHz range. There are 3 times more biological “Effect” than “No Effect” papers; nearly a third of papers provide no funding statement; industry-funded studies more often than not find “No Effect”, while institutional funding commonly reveal “Effects”. Country of origin where the study is conducted/funded also appears to have a dramatic influence on the likely result outcome.
Progress in research on the role of Omi/HtrA2 in neurological diseases
Authors: Su Xiao Juan , Huang Lingyi , Qu Yi , Mu Dezhi 
Published: September 2018

Abstract
Omi/HtrA2 is a serine protease present in the mitochondrial space. When stimulated by external signals, HtrA2 is released into the mitochondrial matrix where it regulates cell death through its interaction with apoptotic and autophagic signaling pathways. Omi/HtrA2 is closely related to the pathogenesis of neurological diseases, such as neurodegeneration and hypoxic ischemic brain damage. Here, we summarize the biological characteristics of Omi/HtrA2 and its role in neurological diseases, which will provide new hints in developing Omi/HtrA2 as a therapeutic target for neurological diseases.
Cyclosporine-A induces apoptosis in human prostate cancer cells PC3 and DU145 via downregulation of COX-2 and upregulation of TGFβ
Authors: Cevik Ozge , Turut Fatma Aysun , Acidereli Hilal , Yildirim Sahin 
Published: September 2018

Abstract

Background
Potential targets for prostate cancer therapy are urgently needed for curative of patients. Cyclosporine-A (CsA), an immunosuppressive and a selective cyclooxygenase-2 (COX-2) inhibitor, exerts antitumor activity. However, the molecular effects of CsA is not fully understood in prostate cancer. In this research, we sought to determine role and mechanism of CsA in prostate cancer.

Materials and methods
PC3 and DU145 cells were treated with CsA time (12, 24, 48 h) and dose dependent (2.5, 10, 25 μM) and cell survival, migration, colony formation, expression of apoptosis related proteins/genes using MTT assay, scratch assay, Western blotting/qPCR. At the same time, cells treated with CsA to test on the effects of COX-2 promoter activity using luciferase reporter plasmid. Lastly, functional role in the CsA treatment prostate cancer cells were interrogated for relationship of TGFβ, Akt, caspases and COX-2.

Results
These study findings provided direct evidences that the CsA induced apoptosis and downregulated migration.

Conclusions
CsA downregulated Akt as well as COX-2 and upregulated TGFβ, resulting in the suppression of cell migration which was augmented a potential therapeutic of CsA in prostate cancer cells.
Acercándonos al dibujo a través de un proyecto audiovisual / Approaching the drawing through an audiovisual project
Authors: Horno López Antonio , Garrido Parrilla Joaquín David 
Published: September 2018

Es bien conocido la apuesta de la educación por la innovación y unas metodologías de aprendizaje que vayan más allá de los recursos tradicionales utilizados dentro de las aulas. El uso de nuevas tecnologías, la incorporación de sonido, imagen y movimiento, crea un nuevo recurso metodológico que permite la integración y participación del alumnado en las actividades de clase. En este trabajo se analizan las ventajas e inconvenientes encontrados durante la ejecución de un proyecto audiovisual en la asignatura “Las Artes Plásticas y Cultura Audiovisual en Educación Primaria” en la Universidad de Jaén, en el que a través de la incorporación de las herramientas digitales más actuales y la disposición de los alumnos en grupos de trabajo se ha logrado fomentar el trabajo cooperativo y el interés de unos estudiantes saturados, en muchas ocasiones, por los trabajos teóricos y las clases magistrales.
Phenomena of Physics Taking Place During Hardening of Steel Parts in Liquid Media That Can Be Investigated by Liščić/Petrofer Probe
Authors: Kobasko Nikolai I. 
Published: September 2018

AbstractThis article discusses some phenomena of physics taking place during the quenching of steel parts in liquid media, such as the formation of a double surface electrical layer, poker effect, the existence of the second spike of the cooling rate during the quenching of the standard probe in salt water and alkali water solutions, and the self-regulation of the part surface temperature during the transient nucleate boiling process. A double electrical layer is conceived around the steel part surface during quenching in salt water or alkali water solutions. This layer prevents the film boiling during quenching because of electrical forces arising in it. This is a reason for maximizing critical heat flux densities. When immersing the quench probe into a salt (alkali) water solution, the probe surface temperature drops almost instantly (within 1–2 s) to the liquid boiling point and remains at this level for a relatively long time. A so-called self-regulated thermal process takes place; such a process is possible because of a significant difference between boiling and convection Biot numbers. A new quenching technology that allows for the austempering process to be performed in cold liquids is discussed in the article. It is shown that a Liščić/Petrofer probe can be successfully used for investigations of the discovered phenomena and for controlling austempering processes in cold liquids.
A Study on the Effect of Austempering Temperature on Microstructure and Mechanical Properties of DIN 36CrNiMo4 Carbide-Free Nano Bainitic Steel
Authors: Garmeh Behdad , Kasiri-Asgarani Masoud , Amini Kamran , Ghayour Hamid 
Published: September 2018

Abstract
In this study, the effects of the austempering temperature on the microstructure and mechanical properties of carbide-free nano bainitic steel (CFB) were discussed. For the achievement of CFB 2 wt. %, silicon was added to DIN 36CrNiMo4 steel, austempered at 450°C and 300°C for 1.5 hours and 10 hours, respectively, and then quenched in oil. The microstructure was studied by optical microscope, scanning electron microscope, and X-ray crystallography. The results showed that the 300°C austempered samples contained the ferrite phase to a greater degree than the martensitic phase. The higher amounts of martensite in the 450°C austempered samples were due to the higher amounts of initial retaining austenite that transformed to martensite in oil quenching. Also, in the samples where carbide participated, there were lower degrees of the martensitic phase, and no carbides afford higher impact toughness and lower hardness for the 300°C austempered sample. As a result of the higher impact toughness in the ball mill wear test, the 300°C austempered sample has a lower weight loss than the 450°C austempered sample.
The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells
Authors: Cheli Veronica T. , Santiago González Diara A. , Marziali Leandro N. , Zamora Norma N. , Guitart María E. , Spreuer Vilma , Pasquini Juana M. , Paez Pablo M. 
Published: September 2018

The divalent metal transporter 1 (DMT1) is a multimetal transporter with a primary role in iron transport. Although DMT1 has been described previously in the CNS, nothing was known about the role of this metal transporter in oligodendrocyte maturation and myelination. To determine whether DMT1 is required for oligodendrocyte progenitor cell (OPC) maturation, we used siRNAs and theCre-loxsystem to knock down/knock out DMT1 expressionin vitroas well asin vivo. Blocking DMT1 synthesis in primary cultures of OPCs reduced oligodendrocyte iron uptake and significantly delayed OPC development.In vivo, a significant hypomyelination was found in DMT1 conditional knock-out mice in which DMT1 was postnatally deleted in NG2- or Sox10-positive OPCs. The brain of DMT1 knock-out animals presented a decrease in the expression levels of myelin proteins and a substantial reduction in the percentage of myelinated axons. This reduced postnatal myelination was accompanied by a decrease in the number of myelinating oligodendrocytes and a rise in proliferating OPCs. Furthermore, using the cuprizone model of demyelination, we established that DMT1 deletion in NG2-positive OPCs lead to less efficient remyelination of the adult brain. These results indicate that DMT1 is vital for OPC maturation and for the normal myelination of the mouse brain.SIGNIFICANCE STATEMENTTo determine whether divalent metal transporter 1 (DMT1), a multimetal transporter with a primary role in iron transport, is essential for oligodendrocyte development, we created two conditional knock-out mice in which DMT1 was postnatally deleted in NG2- or Sox10-positive oligodendrocyte progenitor cells (OPCs). We have established that DMT1 is necessary for normal OPC maturation and is required for an efficient remyelination of the adult brain. Since iron accumulation by OPCs is indispensable for myelination, understanding the iron incorporation mechanism as well as the molecules involved is critical to design new therapeutic approaches to intervene in diseases in which the myelin sheath is damaged or lost.
Revisiting the Circus with Huckleberry Finn: Huck's Pleasure and Mine
Authors: Hochman Barbara 
Published: September 2018

With the exception of occasional quiet moments on the raft, the circus scene in the adventures of huckleberry finn is arguably the only episode of the novel where Huck is absorbed by an experience that gives him pleasure:
I went to the circus. … It was a real bully circus. It was the splendidest sight that ever was, when they all come riding in two and two, a gentleman and lady, side by side, the men just in their drawers and undershirts and no shoes nor stirrups, and resting their hands on their thighs, easy and comfortable—there must a' been twenty of them— and every lady with a lovely complexion, and perfectly beautiful, and looking just like a gang of real sure-enough queens. … It was a powerful fine sight. I never see anything so lovely. … (Twain 134–35)
TÜRKİYE’DE KIRSAL KALKINMADA BÖLGE KALKINMA AJANSLARININ ROLÜ
Authors: MAMUR IŞIKÇI Yasemin 
Published: September 2018

2003 yılı Avrupa Birliği Katılım Ortaklığı Belgesinde, katılım öncesi mali yardım programından yararlanabilmenin koşulu 08.02.2006 tarihli ve 5449 sayılı Kalkınma Ajanslarının Kuruluşu, Koordinasyonu ve Görevleri Hakkında Kanun ile kurulan Kalkınma Ajansları bölgenin kırsal ve yerel kalkınma ile ilgili kapasitesinin geliştirilmesine katkıda bulunmak ve bu kapsamdaki projelere destek sağlamakla yükümlü tutulmuşlardır. Bu çalışmanın amacı da Kalkınma Ajansları’nın kırsal kalkınmaya hangi şekilde ve ne oranda katkı sağladıklarını ortaya koymaktır. Bu değerlendirmeyi yapmak üzere Türkiye’de bulunan mevcut 26 Kalkınma Ajansı’nıdan, Batı Akdeniz Kalkınma Ajansı ( BAKA),Doğu Anadolu Kalkınma Ajansı (DOĞAKA), Doğu Karadeniz Kalkınma Ajansı (DOKA), Güney Ege Kalkınma Ajansı (GEKA), İpekyolu Kalkınma Ajansı (İKA), KARACADAĞ ve Trakya Kalkınma Ajansı (TRAKYAKA)’nın 2016 yılları faaliyet raporları ve bölge planları taranmış ve uzmanlarla mülakat yapılmıştır.
BOŞANMANIN SOSYO-EKONOMİK NEDENLERİ ÜZERİNE MEKÂNSAL EKONOMETRİK BİR İNCELEME
Authors: Cafrı Reyhan , Özdemir Çukadar Pınar 
Published: September 2018

Aile, toplumsal yapının en temel
kurumudur. Bireylerin evlilik yoluyla aile kurma kararı almasının nedenleri
gibi boşanma yoluyla evliliği sonlandırmasının nedenleri de sosyal bilimciler
açısından merak uyandıran bir konudur. Hem ulusal hem de uluslararası ölçekte
yapılan incelemeler, boşanma oranlarındaki artışı çoğunlukla sanayileşmenin
toplumsal yapı üzerinde yarattığı etkilere bağlamaktadır. Türkiye’de tarım
toplumundan sanayi toplumuna geçişle birlikte hızla şehirleşme sürecine giren,
geleneksel aile ve cinsiyet rollerinin değişim geçirdiği bir ülkedir. Bu
değişim aile, evlilik ve boşanma gibi olgulara bakışta da önemli etkiler yaratmıştır.
Bu çalışmanın amacı, Türkiye’de artan boşanma oranlarında etkili olan
sosyoekonomik unsurları mekânsal ekonometri yardımı ile tespit etmektir. Elde edilen bulgular sonucunda, ilköğretim
veya alt eğitim seviyesi, işsizlik oranı ve doğurganlık hızı artışı boşanma
hızını azaltıcı faktörler olarak bulunurken; GSYH, kadın istihdamı, hastalık,
lise/MYO/lisans eğitim seviyeleri, suç artışı, internete erişim ve erkeklerin
evlilikten memnuniyetsizliği boşanmayı arttırıcı unsurlar olarak tespit
edilmiştir.
Lições de ‘Buen Vivir’: impactos ambientais sobre as comunidades indígenas no Brasil contemporâneo
Authors: Wenczenovicz Thaís Janaina , De Marco Cristhian Magnus 
Published: September 2018

Durante muito tempo a questão indígena esteve centrada na figura do indígena propriamente dito, ou seja, na utilização da sua força de trabalho, nos questionamentos de sua natureza humana e no impasse de serem considerados ou não cidadãos brasileiros. Atualmente os objetos de estudo e procedimentos metodológicos foram alargados e o foco da questão indígena foi transferido da identidade desses povos para a conservação da biodiversidade regional e global, demarcação territorial, etnocídio, exploração das suas terras, violência, dentre outros. O devido estudo tem por objetivo analisar elementos acerca dos impactos ambientais desencadeados nas comunidades indígenas com a redefinição de seus territórios e a implantação de grandes construções, especialmente as hidrelétricas e mineradoras. O estudo utiliza-se do procedimento metodológico bibliográfico-investigativo e de pesquisa jurisprudencial.
DUKUNGAN SUAMI TERHADAP PEMBERIAN ASI EKSKLUSIF PADA BAYI USIA 6-12 BULAN
Authors: Rahmawati Aulia , Susilowati Budi 
Published: September 2018

Husband's support having a role in the success or failure of a mother to breastfeed her baby. The greater the support obtained to breastfeed, the greater the ability to survive. This research aimed to know the husband support with exclusive breastfeeding on infants aged 6-12 months. This research is a non experimental. Time approach used in this study is cross-sectional. The sampling technique used purposive sampling. In conducting data analysis of research results using Kendal Tau formula. This research was conducted at Posyandu Dewisari Kenteng Gadingsari Sanden Bantul Yogyakarta. The population in the study were 44 respondents. The samples in the study were 30 respondents,who had infants aged 6 to 12 months. This study showed that the support of husbands in exclusive breastfeeding included in high category as much as 70%, medium category 6.7% and low category 23.3%. The number of mothers who give exclusive breastfeeding in Posyandu Dewisari many as 16 mothers (53.3%). Mothers who didn't breastfeed exclusively are 14 women (46.7%). Based on the results of the relationship test is known that there is a relationship of support of the husband with exclusive breastfeeding. It can be concluded if there is a relationship with the husband's support exclusive in breastfeeding. The socialization of the Health Promotion Program needs to be disseminated through various communication media for couples, families and the environment so that husbands' support for exclusive breastfeeding is met. In addition, the husband as the head of the household needs to perform his role as a “support system”, so that the mother can give exclusive breastfeeding by providing support, appreciation, emotional and instrumental for mother that breastfeeding the babies until 6 months, so she can give exclusive breastfeeding.Keywords: Husband support , Exclusive Breastfeeding
Preemergence Herbicide Effects on Establishment and Tensile Strength of Sprigged Hybrid Bermudagrass
Authors: Begitschke Erick G. , McCurdy James D. , Tseng Te‐Ming , Barickman T. Casey , Stewart Barry R. , Baldwin Christian M. , Richard Michael P. , Ward Jason K. 
Published: September 2018

Core Ideas
Preemergence herbicides may increase grow‐in time for hybrid bermudagrass sprigs.
Preemergence herbicide treatments did not reduce sod tensile strength.
Preemergence herbicides are viable options for weed control during establishment.
Preemergence herbicides often negatively affect establishment of sprigged hybrid bermudagrass (Cynodon dactylon (L.) Pers. × C. transvaalensis Burtt‐Davy). However, limited research has quantified the effects of preemergence herbicides on establishment and tensile strength of warm‐season turfgrass species commonly grown as sod in the southeastern United States. Field research was conducted at Mississippi State University in 2016 and 2017 to evaluate the effects of atrazine, atrazine + S‐metolachlor, dithiopyr, flumioxazin, indaziflam, liquid‐ and granular‐applied oxadiazon, S‐metolachlor, pendimethalin, prodiamine, and simazine on grow‐in time and tensile strength of newly sprigged ‘Latitude 36’ hybrid bermudagrass. Plots (4.65 m2) were sprigged at a rate of 44 m3 ha−1 (468 US bushels ac−1), and preemergence herbicide treatments were applied at the recommended labeled rates 1 d after planting. Dithiopyr, flumioxazin, S‐metolachlor, and indaziflam increased days to reach 50% hybrid bermudagrass cover in both 2016 and 2017. Normalized difference vegetative index and relative chlorophyll index were similarly affected. No herbicide treatments reduced sod tensile strength in either year; however, prodiamine, pendimethalin, dithiopyr, flumioxazin, and S‐metolachlor unexpectedly increased sod tensile strength in 2017.