bluuebunny/crossref_metadata_2025_split huggingface dataset:
Money, Interest, and Policy
Authors: Benassy Jean-Pascal 
Published: August 2019

An important recent advance in macroeconomics is the development of dynamic stochastic general equilibrium (DSGE) macromodels. The use of DSGE models to study monetary policy, however, has led to paradoxical and puzzling results on a number of central monetary issues including price determinacy and liquidity effects. In Money, Interest, and Policy, Jean-Pascal Bénassy argues that moving from the standard DSGE models – which he calls "Ricardian" because they have the famous "Ricardian equivalence" property–to another, "non-Ricardian" model would resolve many of these issues. A Ricardian model represents a household as a homogeneous family of infinitely lived individuals, and Bénassy demonstrates that a single modification–the assumption that new agents are born over time (which makes the model non-Ricardian)–can bridge the current gap between monetary intuitions and facts, on one hand, and rigorous modeling, on the other.
After comparing Ricardian and non-Ricardian models, Bénassy introduces a model that synthesizes the two approaches, incorporating both infinite lives and the birth of new agents. Using this model, he considers a number of issues in monetary policy, including liquidity effects, interest rate rules and price determinacy, global determinacy, the Taylor principle, and the fiscal theory of the price level. Finally, using a simple overlapping generations model, he analyzes optimal monetary and fiscal policies, with a special emphasis on optimal interest rate rules.
Invented Edens
Authors: Kargon Robert H. , Molella Arthur P. 
Published: August 2019

Tracing the design of “techno-cities” that blend the technological and the pastoral.
Industrialization created cities of Dickensian squalor that were crowded, smoky, dirty, and disease-ridden. By the beginning of the twentieth century, urban visionaries were looking for ways to improve both living and working conditions in industrial cities. In Invented Edens, Robert Kargon and Arthur Molella trace the arc of one form of urban design, which they term the techno-city: a planned city developed in conjunction with large industrial or technological enterprises, blending the technological and the pastoral, the mill town and the garden city. Techno-cities of the twentieth century range from factory towns in Mussolini's Italy to the Disney creation of Celebration, Florida.
Kargon and Molella show that the techno-city represents an experiment in integrating modern technology into the world of ideal life. Techno-cities mirror society's understanding of current technologies, and at the same time seek to regain the lost virtues of the edenic pre-industrial village. The idea of the techno-city transcended ideologies, crossed national borders, and spanned the entire twentieth century. Kargon and Molella map the concept through a series of exemplars. These include Norris, Tennessee, home to the Tennessee Valley Authority; Torviscosa, Italy, built by Italy's Fascist government to accommodate synthetic textile manufacturing (and featured in an early short by Michelangelo Antonioni); Ciudad Guayana, Venezuela, planned by a team from MIT and Harvard; and, finally, Disney's Celebration—perhaps the ultimate techno-city, a fantasy city reflecting an era in which virtual experiences are rapidly replacing actual ones.
Metabolomic analysis reveals the mechanism of aluminum cytotoxicity in HT-29 cells
Authors: Yu Leilei , Wu Jiangping , Zhai Qixiao , Tian Fengwei , Zhao Jianxin , Zhang Hao , Chen Wei 
Published: August 2019

BackgroundAluminum (Al) is toxic to animals and humans. The most common sources of human exposure to Al are food and beverages. The intestinal epithelium is the first barrier against Al-induced toxicity. In this study, HT-29, a human colon cancer cell line, was selected as an in vitro model to evaluate the Al-induced alteration in metabolomic profiles and explore the possible mechanisms of Al toxicity.MethodsMTT assay was performed to determine the half-maximal inhibitory concentration of Al ions. Liquid chromatography-mass spectrometry (LC-MS) was used for metabolomic analysis, and its results were further confirmed using quantitative reverse transcription polymerase chain reaction (RT-qPCR) of nine selected genes.ResultsAl inhibited the growth of the HT-29 cells, and its half-maximal dose for the inhibition of cell proliferation was found to be four mM. This dose was selected for further metabolomic analysis, which revealed that 81 metabolites, such glutathione (GSH), phosphatidylcholines, phosphatidylethanolamines, and creatine, and 17 metabolic pathways, such as the tricarboxylic acid cycle, pyruvate metabolism, and GSH metabolism, were significantly altered after Al exposure. The RT-qPCR results further confirmed these findings.ConclusionThe metabolomics and RT-qPCR results indicate that the mechanisms of Al-induced cytotoxicity in HT-29 cells include cellular apoptosis, oxidative stress, and alteration of lipid, energy, and amino acid metabolism.
Marked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum
Authors: Foysal Md Javed , Nguyen Thi Thu Thuy , Chaklader Md Reaz , Siddik Muhammad A.B. , Tay Chin-Yen , Fotedar Ravi , Gupta Sanjay Kumar 
Published: August 2019

This study aimed to investigate the effects of Clostridium butyricum as a dietary probiotic supplement in fishmeal based diet on growth, gut microbiota and immune performance of marron (Cherax cainii). Marron were randomly distributed into two different treatment groups, control and probiotic fed group. After 42 days of feeding trial, the results revealed a significant (P < 0.05) increase in growth due to increase in number of moults in marron fed probiotics. The probiotic diet also significantly enhanced the total haemocyte counts (THC), lysozyme activity in the haemolymph and protein content of the tail muscle in marron. Compared to control, the 16S rRNA sequences data demonstrated an enrichment of bacterial diversity in the probiotic fed marron where significant increase of Clostridium abundance was observed. The abundance for crayfish pathogen Vibrio and Aeromonas were found to be significantly reduced post feeding with probiotic diet. Predicted metabolic pathway revealed an increased activity for the metabolism and absorption of carbohydrate, degradation of amino acid, fatty acid and toxic compounds, and biosynthesis of secondary metabolites. C. butyricum supplementation also significantly modulated the expression level of immune-responsive genes of marron post challenged with Vibrio mimicus. The overall results suggest that C. butyricum could be used as dietary probiotic supplement in marron aquaculture.
Simultaneous Profiling of Gene Expression and Chromatin Accessibility in Single Cells
Authors: Reyes Miguel , Billman Kianna , Hacohen Nir , Blainey Paul C. 
Published: August 2019

AbstractProfiling multiple omic layers in a single cell enables the discovery and analysis of biological phenomena that are not apparent from analysis of mono‐omic data. While methods for multiomic profiling have been reported, their adoption has been limited due to high cost and complex workflows. Here, a simple method for joint profiling of gene expression and chromatin accessibility in tens to hundreds of single cells is presented. Assessed herein is the quality of resulting single cell ATAC‐ and RNA‐seq data across three cell types, examining the link between accessibility and expression at the CD3G and FTH1 loci in human primary T cells and monocytes, and comparing the accuracy of clustering solutions for mono‐omic and combined data. The new method allows biological laboratories to perform simultaneous profiling of gene expression and chromatin accessibility using standard reagents and instrumentation. This technique, in conjunction with other advances in multiomic profiling, will enable highly resolved cell state classification and more specific mechanistic hypothesis generation than is possible with mono‐omic analysis.
Precise Molecular Engineering of Photosensitizers with Aggregation‐Induced Emission over 800 nm for Photodynamic Therapy
Authors: Wu Wenbo , Mao Duo , Xu Shidang , Panahandeh‐Fard Majid , Duan Yukun , Hu Fang , Kong Deling , Liu Bin 
Published: August 2019

AbstractOwing to efficient singlet oxygen (1O2) generation in aggregate state, photosensitizers (PSs) with aggregation‐induced emission (AIE) have attracted much research interests in photodynamic therapy (PDT). In addition to high 1O2 generation efficiency, strong molar absorption in long‐wavelength range and near‐infrared (NIR) emission are also highly desirable, but difficult to achieve for AIE PSs since the twisted structures in AIE moieties usually lead to absorption and emission in short‐wavelength range. In this contribution, through acceptor engineering, a new AIE PS of TBT is designed to show aggregation‐induced NIR emission centered at 810 nm, broad absorption in the range between 300 and 700 nm with a large molar absorption coefficient and a high 1O2 generation efficiency under white light irradiation. Further, donor engineering by attaching two branched flexible chains to TBT yielded TBTC8, which circumvented the strong intermolecular interactions of TBT in nanoparticles (NPs), yielding TBTC8 NPs with optimized overall performance in 1O2 generation, absorption, and emission. Subsequent PDT results in both in vitro and in vivo studies indicate that TBTC8 NPs are promising candidates in practical application.
The Promise and Challenge of Phosphorus‐Based Composites as Anode Materials for Potassium‐Ion Batteries
Authors: Wu Ying , Huang Hai‐Bo , Feng Yuezhan , Wu Zhong‐Shuai , Yu Yan 
Published: August 2019

AbstractPotassium‐ion batteries (KIBs) are a core energy storage device that can meet the need for scalable and affordable stationary applications because they use low‐cost and earth‐abundant potassium. In addition, KIB shares a similar storage mechanism with current Li‐ion batteries. As the key to optimizing a battery's performance, the development of high‐performance electrode materials helps to increase the feasibility of KIB technology. In this sense, phosphorus‐based materials (i.e., phosphorus and metal phosphide) with high theoretical capacity and low redox potential tick all the right boxes as a material of choice. A rapid glimpse at recent studies on phosphorus‐based anode materials for advanced KIBs is provided, covering the synthetic methods, reaction mechanisms, electrochemical properties, and performances. In addition, several promising strategies are highlighted to address the imminent challenges faced by phosphorus‐based anode materials, hoping to cast an insightful outlook for possible future direction in this field.
Targeted Therapy for Interfacial Engineering Toward Stable and Efficient Perovskite Solar Cells
Authors: Wang Shuhui , Chen Haiyang , Zhang Jiandong , Xu Guiying , Chen Weijie , Xue Rongming , Zhang Moyao , Li Yaowen , Li Yongfang 
Published: August 2019

AbstractThe poor long‐term stability of organic–inorganic hybrid halide perovskite solar cells (pero‐SCs) remains a big challenge for their commercialization. Although strategies such as encapsulation, doping, and passivation have been reported, there remains a lack of understanding of the water resistance and thermal stability of pero‐SCs. A fullerene derivative, [6,6]‐phenyl‐C61‐butyric acid‐N,N‐dimethyl‐3‐(2‐thienyl)propanam ester (PCBB‐S‐N) containing a functional sulfur atom and C60,is synthesized and employed as electron transporting layer (ETL)/intermediary layer to targetedly heal the multitype defects in pero‐SCs or assist the growth of ETL, such as [6,6]‐phenyl‐C61‐butyric acid methyl ester (PCBM), in planarp‐i‐npero‐SCs. The repaired pero‐SCs can not only dramatically improve their power conversion efficiencies, but also address stability issues under moisture and high temperature. The corresponding mechanism of PCBB‐S‐N with targeted therapy effect in a device is systematically investigated by both experiments and theoretical calculation. This work demonstrates that the proposed fullerene derivative with finely tuned chemical structure can be a promising ETL candidate or intermediary to approach stable and efficient planarp‐i‐npero‐SCs.
Layered Structure Causes Bulk NiFe Layered Double Hydroxide Unstable in Alkaline Oxygen Evolution Reaction
Authors: Chen Rong , Hung Sung‐Fu , Zhou Daojin , Gao Jiajian , Yang Cangjie , Tao Huabing , Yang Hong Bin , Zhang Liping , Zhang Lulu , Xiong Qihua , Chen Hao Ming , Liu Bin 
Published: August 2019

AbstractNiFe‐based layered double hydroxides (LDHs) are among the most efficient oxygen evolution reaction (OER) catalysts in alkaline medium, but their long‐term OER stabilities are questionable. In this work, it is demonstrated that the layered structure makes bulk NiFe LDH intrinsically not stable in OER and the deactivation mechanism of NiFe LDH in OER is further revealed. Both operando electrochemical and structural characterizations show that the interlayer basal plane in bulk NiFe LDH contributes to the OER activity, and the slow diffusion of proton acceptors (e.g., OH−) within the NiFe LDH interlayers during OER causes dissolution of NiFe LDH and therefore decrease in OER activity with time. To improve diffusion of proton acceptors, it is proposed to delaminate NiFe LDH into atomically thin nanosheets, which is able to effectively improve OER stability of NiFe LDH especially at industrial operating conditions such as elevated operating temperatures (e.g., at 80 °C) and large current densities (e.g., at 500 mA cm−2).
Severe lung disease characterized by lymphocytic bronchiolitis, alveolar ductitis, and emphysema (BADE) in industrial machine‐manufacturing workers
Authors: Cummings Kristin J. , Stanton Marcia L. , Nett Randall J. , Segal Leopoldo N. , Kreiss Kathleen , Abraham Jerrold L. , Colby Thomas V. , Franko Angela D. , Green Francis H.Y. , Sanyal Soma , Tallaksen Robert J. , Wendland Douglas , Bachelder Vance D. , Boylstein Randy J. , Park Ju‐Hyeong , Cox‐Ganser Jean M. , Virji M. Abbas , Crawford Judith A. , Green Brett James , LeBouf Ryan F. , Blaser Martin J. , Weissman David N. 
Published: August 2019

AbstractBackgroundA cluster of severe lung disease occurred at a manufacturing facility making industrial machines. We aimed to describe disease features and workplace exposures.MethodsClinical, functional, radiologic, and histopathologic features were characterized. Airborne concentrations of thoracic aerosol, metalworking fluid, endotoxin, metals, and volatile organic compounds were measured. Facility airflow was assessed using tracer gas. Process fluids were examined using culture, polymerase chain reaction, and 16S ribosomal RNA sequencing.ResultsFive previously healthy male never‐smokers, ages 27 to 50, developed chest symptoms from 1995 to 2012 while working in the facility's production areas. Patients had an insidious onset of cough, wheeze, and exertional dyspnea; airflow obstruction (mean FEV1 = 44% predicted) and reduced diffusing capacity (mean = 53% predicted); and radiologic centrilobular emphysema. Lung tissue demonstrated a unique pattern of bronchiolitis and alveolar ductitis with B‐cell follicles lacking germinal centers, and significant emphysema for never‐smokers. All had chronic dyspnea, three had a progressive functional decline, and one underwent lung transplantation. Patients reported no unusual nonoccupational exposures. No cases were identified among nonproduction workers or in the community. Endotoxin concentrations were elevated in two air samples; otherwise, exposures were below occupational limits. Air flowed from areas where machining occurred to other production areas. Metalworking fluid primarily grew Pseudomonas pseudoalcaligenes and lacked mycobacterial DNA, but 16S analysis revealed more complex bacterial communities.ConclusionThis cluster indicates a previously unrecognized occupational lung disease of yet uncertain etiology that should be considered in manufacturing workers (particularly never‐smokers) with airflow obstruction and centrilobular emphysema. Investigation of additional cases in other settings could clarify the cause and guide prevention.
Chemical Patterning in Single Crystals of Metal–Organic Frameworks by [2+2] Cycloaddition Reaction
Authors: Park In‐Hyeok , Lee Eunji , Lee Shim Sung , Vittal Jagadese J. 
Published: August 2019

AbstractConventional chemical patterning involves films of polymeric materials. Herein, we demonstrate that the presence or absence of guest solvents in the crystal voids modulates the patterning of the cyclobutane rings in highly strained metal–organic frameworks (MOFs) under UV light. The olefin pairs of the spacer ligands, which resemble a ladder‐like structure, in the MOF, undergo a [2+2] cycloaddition reaction in a single‐crystal‐to‐single‐crystal manner. For instance, a partial photoreaction in the MOFs in the absence of a guest solvent as well as with dimethylacetamide in the voids generated two different patterns of the cyclobutane rings. Surprisingly, the MOF with the lattice dimethylformamide undergoes 100 % photoreaction, but the photoproduct contains broken chains. Such chemical patterning at the molecular level represents a next step in crystal engineering.
Catalytic Living Ring Opening Metathesis Polymerisation: The Importance of Ring Strain in Chain Transfer Agents
Authors: Liu Peng , Yasir Mohammad , Kilbinger Andreas F. M. 
Published: August 2019

AbstractA recently developed catalytic living ring opening metathesis polymerisation (ROMP) was investigated using a series of reversible chain transfer agents (CTA) carrying either cyclopentene or cyclohexene rings, differing only in ring strain. All cyclopentene derivatives examined showed significantly faster reaction rates than the corresponding cyclohexene derivatives. This resulted in lower molecular weight dispersities and better control of the molecular weight for the cyclopentene compared to the cyclohexene CTAs. Both Grubbs’ second and third generation catalysts could be employed in catalytic living ROMP using cyclopentene CTA derivatives. The kinetics of different CTAs were studied, block copolymers were synthesised and residual ruthenium quantified by ICP‐OES. All polymers were fully characterised by NMR, GPC and MALDI‐ToF mass spectrometry. The new cyclopentene CTAs are readily synthesised in a few straightforward steps and provide faster reaction kinetics than all previously reported reversible CTAs.
A Stark Contrast to Modern Earth: Phosphate Mineral Transformation and Nucleoside Phosphorylation in an Iron‐ and Cyanide‐Rich Early Earth Scenario
Authors: Burcar Bradley , Castañeda Alma , Lago Jennifer , Daniel Mischael , Pasek Matthew A. , Hud Nicholas V. , Orlando Thomas M. , Menor‐Salván César 
Published: August 2019

AbstractOrganophosphates were likely an important class of prebiotic molecules. However, their presence on the early Earth is strongly debated because the low availability of phosphate, which is generally assumed to have been sequestered in insoluble calcium and iron minerals, is widely viewed as a major barrier to organophosphate generation. Herein, we demonstrate that cyanide (an essential prebiotic precursor) and urea‐based solvents could promote nucleoside phosphorylation by transforming insoluble phosphate minerals in a “warm little pond” scenario into more soluble and reactive species. Our results suggest that cyanide and its derivatives (metal cyanide complexes, urea, ammonium formate, and formamide) were key reagents for the participation of phosphorus in chemical evolution. These results allow us to propose a holistic scenario in which an evaporitic environment could concentrate abiotically formed organics and transform the underlying minerals, allowing significant organic phosphorylation under plausible prebiotic conditions.
Defect‐Rich Adhesive Nanozymes as Efficient Antibiotics for Enhanced Bacterial Inhibition
Authors: Cao Fangfang , Zhang Lu , Wang Huan , You Yawen , Wang Ying , Gao Nan , Ren Jinsong , Qu Xiaogang 
Published: August 2019

AbstractNanozymes have emerged as a new generation of antibiotics with exciting broad‐spectrum antimicrobial properties and negligible biotoxicities. However, their antibacterial efficacies are unsatisfactory due to their inability to trap bacteria and their low catalytic activity. Herein, we report nanozymes with rough surfaces and defect‐rich active edges. The rough surface increases bacterial adhesion and the defect‐rich edges exhibit higher intrinsic peroxidase‐like activity compared to pristine nanozymes due to their lower adsorption energies of H2O2 and desorption energy of OH*, as well as the larger exothermic process for the whole reaction. This was demonstrated using drug‐resistant Gram‐negative Escherichia coli and Gram‐positive Staphylococcus aureus in vitro and in vivo. This strategy can be used to engineer nanozymes with enhanced antibacterial function and will pave a new way for the development of alternative antibiotics.
Atroposelective Phosphoric Acid Catalyzed Three‐Component Cascade Reaction: Enantioselective Synthesis of Axially Chiral N‐Arylindoles
Authors: Wang Lei , Zhong Jialing , Lin Xufeng 
Published: August 2019

AbstractAn efficient organocatalytic atroposelective three‐component cascade reaction of 2,3‐diketoesters, aromatic amines, and 1,3‐cyclohexanediones has been developed for the highly enantioselective synthesis of axially chiral N‐arylindoles. The success of this method derives from the use of a newly developed second‐generation chiral spirocyclic phosphoric acid as the catalyst. In addition, this protocol was extended to the synthesis of an axially chiral monophosphorus ligand.
Elaborating Complex Heteroaryl‐Containing Cycles via Enantioselective Palladium‐Catalyzed Cycloadditions
Authors: Trost Barry M. , Jiao Zhiwei , Hung Chao‐I. (Joey) 
Published: August 2019

AbstractA general method for asymmetric synthesis of heteroaryl‐containing cycles via palladium‐catalyzed cyclization is reported. Most classes of nitrogen‐containing aromatics, including pyridines, quinolines, pyrimidines, various azoles and the derivatives of nucleobases are compatible substrates, offering various heteroaryl‐substituted cyclopentane, pyrrolidine, furanidine and bicyclo[4.3.1]decadiene derivatives with good to excellent enantioselectivity and diastereoselectivity.
Preparation of Polyfunctional Biaryl Derivatives by Cyclolanthanation of 2‐Bromobiaryls and Heterocyclic Analogues Using nBu2LaCl⋅4 LiCl
Authors: Wei Baosheng , Zhang Dongchao , Chen Yi‐Hung , Lei Aiwen , Knochel Paul 
Published: August 2019

AbstractVarious aryl‐ and heteroaryl‐substituted 2‐bromobiaryls are converted to cyclometalated lanthanum intermediates by reaction with nBu2LaCl⋅4 LiCl. These resulting lanthanum heterocycles are key intermediates for the facile preparation of functionalized 2,2′‐diiodobiaryls, silafluorenes, fluoren‐9‐ones, phenanthrenes, and their related heterocyclic analogues. X‐ray absorption fine structure (XAFS) spectroscopy was used to rationalize the proposed structures of the involved organolanthanum species.