bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self Constitution as The Foundation for Leading Ethically: A Foucauldian Possibility
Authors: Ladkin Donna 
Published: March 2018

ABSTRACT:This article challenges the assumption that the source of ethical leadership is the well-intentioned leader of good character. Drawing from Michel Foucault’s critical philosophy, it argues that those aspiring to lead ethically must actively constitute themselves in order to become subjects who are free to exercise ethical agency. The practices of self-care (epimeileisthai sautou) and courageous speech (parrhesia) are introduced as means by which such self-constitution can be approached. The case of US President Barack Obama’s inability to close the detention centre at Guantanamo Bay serves as an illustrative device to ground Foucault’s ideas. The argument enriches a philosophically informed rendering of ethical leadership in three ways: by highlighting the role resistance plays in any leader’s attempts to achieve ethical ends, by demonstrating the importance of an orientation of critique on the part of those aspiring to lead ethically, and by revealing the importance of followers in realizing ethical outcomes.
The automatic nature of motivated belief updating
Authors: KAPPES ANDREAS , SHAROT TALI 
Published: March 2018

AbstractPeople's risk estimates often do not align with the evidence available to them. In particular, people tend to discount bad news (such as evidence suggesting their risk of being involved in a car accident is higher than they thought) as compared to good news (evidence suggesting it is lower) – this is known as the belief update bias. It has been assumed that individuals use motivated reasoning to rationalise away unwanted evidence (e.g., “I am a safe driver, thus these statistics do not apply to me”). However, whether reasoning is required to discount bad news has not been tested directly. Here, we restrict cognitive resources using a cognitive load (Experiment 1) and a time restriction manipulation (Experiment 3) and find that while these manipulations diminish learning in general, they do not diminish the bias. Furthermore, we also show that the relative neglect of bad news happens the moment new evidence is presented, not when participants are subsequently prompted to state their belief (Experiment 2). Our findings suggest that reasoning is not required for bad news to be discounted as compared to good news.
Reservoir Effects in a Stone Age Fjord on Lolland, Denmark
Authors: Philippsen Bente 
Published: March 2018

ABSTRACTOn the island of Lolland, southeast Denmark, an area of almost 300 ha is currently under archaeological investigation prior to the planned construction of a tunnel between Denmark and Germany under the Femern belt. The area investigated in the context of the “Femern project” includes a former fjord or lagoon, which was used both as an economic resource and as background for ritual activities in the Neolithic. The wetland conditions give excellent preservation conditions for organic material. A yet unsolved issue, however, is the question of reservoir effects. The local reservoir effect needs to be known for accurate radiocarbon (14C) dating of samples with possible aquatic carbon sources, such as human bones or food residues on pottery. Therefore, this paper attempts to calculate the local reservoir effect for the study area. I will discuss the possibilities and limitations when analyzing 14C dates from a rescue excavation. When applying the estimated reservoir corrections to a hoard of jaws and other bones, an interesting change in ritual activity at ca. 4000 cal BC can be observed. Furthermore, I examined 14C dates on bulk organic sediment and will discuss their implications for building chronologies and for reconstructing the environment of the Stone Age fjord. Finally, I will discuss the pitfalls and uncertainties associated with 14C dates for sea level reconstruction.
International Law and the Turn to Political Economy
Authors: HASKELL JOHN , RASULOV AKBAR 
Published: March 2018

AbstractAn increasing number of international law scholars over the last few years have started to turn their attention to the study of political economy. To what extent can this trend be considered an indication of an underlying ‘disciplinary turn’? How should one understand the phenomenon of disciplinary turns? The answer we propose to this question in this article proceeds from the assumption that not all disciplinary shifts follow the same logic. Unlike the linguistic or the historical turn, the turn to political economy in contemporary international law does not represent an exercise in inter-disciplinary exploration. The concept of political economy used in international law has very little to do with the actual discipline of political economy. It is much more diffuse and unfocused in theoretical terms. What gives it its essential sense of identity is not any form of distinct methodological orientation, but rather its basic usefulness as a potential marker of critical self-distancing vis-à-vis the mainstream international law tradition and its ideological function as a mediating device for the expression of a deep-seated concern about the structural injustices of modern capitalism.
Traffic-light labels and financial incentives to reduce sugar-sweetened beverage purchases by low-income Latino families: a randomized controlled trial
Authors: Franckle Rebecca L , Levy Douglas E , Macias-Navarro Lorena , Rimm Eric B , Thorndike Anne N 
Published: March 2018

AbstractObjectiveThe objective of the present study was to test the effectiveness of financial incentives and traffic-light labels to reduce purchases of sugar-sweetened beverages in a community supermarket.DesignIn this randomized controlled trial, after a 2-month baseline period (February–March 2014), in-store traffic-light labels were posted to indicate healthy (green), less healthy (yellow) or unhealthy (red) beverages. During the subsequent five months (April–August 2014), participants in the intervention arm were eligible to earn a $US 25 in-store gift card each month they refrained from purchasing red-labelled beverages.SettingUrban supermarket in Chelsea, MA, USA, a low-income Latino community.SubjectsParticipants were customers of this supermarket who had at least one child living at home. A total of 148 customers (n 77 in the intervention group and n 71 in the control group) were included in the final analyses.ResultsOutcomes were monthly in-store purchases tracked using a store loyalty card and self-reported consumption of red-labelled beverages. Compared with control participants, the proportion of intervention participants who purchased any red-labelled beverages decreased by 9 % more per month (P=0·002). More intervention than control participants reduced their consumption of red-labelled beverages (−23 % v. −2 % for consuming ≥1 red beverage/week, P=0·01).ConclusionsOverall, financial incentives paired with in-store traffic-light labels modestly reduced purchase and consumption of sugar-sweetened beverages by customers of a community supermarket.
Assessing maize diversity and defining a representative subset by means of selected morphological ear traits
Authors: Rincon-Sanchez Froylan , Ruiz-Torres Norma A. 
Published: March 2018

AbstractThe objectives of this study were to analyse the maize diversity in the southeast of Coahuila State in Mexico and to identify a representative subset that encompasses the majority of the diversity in the region of study. Seventy-seven native maize populations were first explored and given a race classification followed by a morphological description based on selected quantitative ear traits using 10 representative ears from the collected samples. The differences between maize populations from the adaptation area and the relationships between and within groups in the region of study indicate the usefulness of the ear traits to describe maize diversity. Two main groups were identified that summarized the maize diversity. The first group, the conical ear complex, includes populations adapted to highland altitudes (Conico Norteño Race). The second group, the cylindrical ear complex, represents populations adapted to lowland and intermediate altitudes (Raton and Tuxpeño Norteño). Using the phenogram, a subset of 18 out of the 77 maize populations (23.4%) was defined that accounts for the variation between and within the different race complexes. This subset also includes at least one representative population from each of the less represented types. The final subset, representing a sample of maize diversity, can be used to establish strategies for conservation and use, such as participatory conservation and management, or it can be used to develop breeding techniques for improving the land race populations within the region of study.
ER–mitochondria signaling in Parkinson’s disease
Authors: Gómez-Suaga Patricia , Bravo-San Pedro José M , González-Polo Rosa A. , Fuentes José M. , Niso-Santano Mireia 
Published: March 2018

Abstract
Mitochondria form close physical contacts with a specialized domain of the endoplasmic reticulum (ER), known as the mitochondria-associated membrane (MAM). This association constitutes a key signaling hub to regulate several fundamental cellular processes. Alterations in ER–mitochondria signaling have pleiotropic effects on a variety of intracellular events resulting in mitochondrial damage, Ca2+ dyshomeostasis, ER stress and defects in lipid metabolism and autophagy. Intriguingly, many of these cellular processes are perturbed in neurodegenerative diseases. Furthermore, increasing evidence highlights that ER–mitochondria signaling contributes to these diseases, including Parkinson’s disease (PD). PD is the second most common neurodegenerative disorder, for which effective mechanism-based treatments remain elusive. Several PD-related proteins localize at mitochondria or MAM and have been shown to participate in ER–mitochondria signaling regulation. Likewise, PD-related mutations have been shown to damage this signaling. Could ER–mitochondria associations be the link between pathogenic mechanisms involved in PD, providing a common mechanism? Would this provide a pharmacological target for treating this devastating disease?
In this review, we aim to summarize the current knowledge of ER–mitochondria signaling and the recent evidence concerning damage to this signaling in PD.
Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice
Authors: Lv Zhimei , Hu Mengsi , Fan Minghua , Li Xiaobing , Lin Jiangong , Zhen Junhui , Wang Ziyang , Jin Haijun , Wang Rong 
Published: March 2018

AbstractActivation of Ras-related C3 botulinum toxin substrate 1 (Rac1) has been implicated in diverse kidney diseases, yet its in vivo significance in diabetic nephropathy (DN) is largely unknown. In the present study, we demonstrated a podocyte-specific Rac1-deficient mouse strain and showed that specific inhibition of Rac1 was able to attenuate diabetic podocyte injury and proteinuria by the blockade of Rac1/PAK1/p38/β-catenin signaling cascade, which reinstated the integrity of podocyte slit diaphragms (SD), rectified the effacement of foot processes (FPs), and prevented the dedifferentiation of podocytes. In vitro, we showed Rac1/PAK1 physically bound to β-catenin and had a direct phosphorylation modification on its C-terminal Ser675, leading to less ubiquitylated β-catenin, namely more stabilized β-catenin, and its nuclear migration under high-glucose conditions; further, p38 activation might be responsible for β-catenin nuclear accumulation via potentiating myocyte-specific enhancer factor 2C (MEF2c) phosphorylation. These findings provided evidence for a potential renoprotective and therapeutic strategy of cell-specific Rac1 deficiency for DN and other proteinuric diseases.
DAX1 promotes cervical cancer cell growth and tumorigenicity through activation of Wnt/β-catenin pathway via GSK3β
Authors: Liu Xiao-Fang , Li Xue-Yuan , Zheng Peng-Sheng , Yang Wen-Ting 
Published: March 2018

AbstractDAX1 is well known for its fundamental role in several types of cancer, while its biological role in cervical cancer remains largely unexplored. The expression of DAX1 in cervical carcinoma tissue was examined using immunohistochemistry and western blot. The effects of DAX1 silencing on the cell growth, tumor formation, and CSC (cancer stem cell) characteristics were also investigated. DAX1 expressed a gradual increase from normal cervix to high-grade squamous intraepithelial lesions, and consequently to cervical cancer. Silence of DAX1 significantly inhibited the cell growth, tumorigenicity, and tumorsphere formation. Furthermore, the TOP/FOP-Flash reporter assay revealed that Wnt/β-catenin pathway was significantly inactivated in DAX1-silenced cervical cancer cells with the downregulation of Wnt/β-catenin targeting genes, including cyclinD1 and c-myc. Moreover, dual-luciferase reporter and chromatin immunoprecipitation (ChIP) assay confirmed that DAX1 transcriptionally repressed glycogen synthase kinase 3β (GSK3β), an inhibitor of the Wnt/β-catenin pathway, by physically interacting with −666~−444 motif on the GSK3β promoter. Additionally, the blockage of GSK3β by CHIR-99021 resulted in a significant increase of CSC characteristics induced by the silence of DAX1. Our data demonstrated that DAX1 is overexpressed in cervical cancer, and that it promotes cell growth and tumorigenicity through activating Wnt/β-catenin pathway mediated by GSK3β.
Proteasome inhibition blocks necroptosis by attenuating death complex aggregation
Authors: Ali Mohammad , Mocarski Edward S. 
Published: March 2018

AbstractProteasome inhibitors have achieved clinical success because they trigger intrinsic and extrinsic cell death to eliminate susceptible human cancers. The ubiquitin-proteasome protein degradation system regulates signaling pathways by controlling levels of components such as cellular inhibitor of apoptosis (cIAP)1 and cIAP2 in TNF-mediated cell death. Here, we sought to evaluate the contribution of necroptosis to the cell death pattern induced by the specific proteasome inhibitor Carfilzomib (Cf). Proteasome inhibitor-sensitive multiple myeloma cell lines die in response to Cf by apoptosis in combination with serine protease-dependent death, without any contribution of RIPK3-dependent necroptosis. Proteasome inhibition leads to the induction of apoptotic markers such as activated caspase-3 rather than necroptotic markers such as phosphorylated-MLKL in all cell lines tested. In HT-29 cells, Cf attenuates the late RIPK1 interaction with TNFR1 during TNF-induced necroptosis without altering the sensitivity of cIAP antagonists. Cf treatment results in decreased translocation of death signaling components RIPK1, FADD, caspase-8, cFLIP, and RIPK3 to detergent insoluble fractions. Our results show that proteasome inhibition with Cf impairs necroptosis and favors apoptosis even in cells with intact necroptotic machinery. Following the induction of TNFR1-mediated necroptosis, proteasome activity stabilizes effective aggregation and activation of ripoptosome/necrosome complexes.
Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila
Authors: Obata Fumiaki , Fons Clara O. , Gould Alex P. 
Published: March 2018

AbstractEnvironmental stresses experienced during development exert many long-term effects upon health and disease. For example, chemical oxidants or genetic perturbations that induce low levels of reactive oxygen species can extend lifespan in several species. In some cases, the beneficial effects of low-dose oxidants are attributed to adaptive protective mechanisms such as mitohormesis, which involve long-term increases in the expression of stress response genes. Here we show in Drosophila that transient exposure to low concentrations of oxidants during development leads to an extension of adult lifespan. Surprisingly, this depends upon oxidants acting in an antibiotic-like manner to selectively deplete the microbiome of Acetobacter proteobacteria. We demonstrate that the presence of Acetobacter species, such as A. aceti, in the indigenous microbiota increases age-related gut dysfunction and shortens lifespan. This study demonstrates that low-dose oxidant exposure during early life can extend lifespan via microbiome remodelling rather than mitohormesis.
Replica molding-based nanopatterning of tribocharge on elastomer with application to electrohydrodynamic nanolithography
Authors: Li Qiang , Peer Akshit , Cho In Ho , Biswas Rana , Kim Jaeyoun 
Published: March 2018

AbstractReplica molding often induces tribocharge on elastomers. To date, this phenomenon has been studied only on untextured elastomer surfaces even though replica molding is an effective method for their nanotexturing. Here we show that on elastomer surfaces nanotextured through replica molding the induced tribocharge also becomes patterned at nanoscale in close correlation with the nanotexture. By applying Kelvin probe microscopy, electrohydrodynamic lithography, and electrostatic analysis to our model nanostructure, poly(dimethylsiloxane) nanocup arrays replicated from a polycarbonate nanocone array, we reveal that the induced tribocharge is highly localized within the nanocup, especially around its rim. Through finite element analysis, we also find that the rim sustains the strongest friction during the demolding process. From these findings, we identify the demolding-induced friction as the main factor governing the tribocharge’s nanoscale distribution pattern. By incorporating the resulting annular tribocharge into electrohydrodynamic lithography, we also accomplish facile realization of nanovolcanos with 10 nm-scale craters.
Ionic liquid gating control of RKKY interaction in FeCoB/Ru/FeCoB and (Pt/Co)2/Ru/(Co/Pt)2 multilayers
Authors: Yang Qu , Wang Lei , Zhou Ziyao , Wang Liqian , Zhang Yijun , Zhao Shishun , Dong Guohua , Cheng Yuxin , Min Tai , Hu Zhongqiang , Chen Wei , Xia Ke , Liu Ming 
Published: March 2018

AbstractTo overcome the fundamental challenge of the weak natural response of antiferromagnetic materials under a magnetic field, voltage manipulation of antiferromagnetic interaction is developed to realize ultrafast, high-density, and power efficient antiferromagnetic spintronics. Here, we report a low voltage modulation of Ruderman–Kittel–Kasuya–Yosida (RKKY) interaction via ionic liquid gating in synthetic antiferromagnetic multilayers of FeCoB/Ru/FeCoB and (Pt/Co)2/Ru/(Co/Pt)2. At room temperature, the distinct voltage control of transition between antiferromagnetic and ferromagnetic ordering is realized and up to 80% of perpendicular magnetic moments manage to switch with a small-applied voltage bias of 2.5 V. We related this ionic liquid gating-induced RKKY interaction modification to the disturbance of itinerant electrons inside synthetic antiferromagnetic heterostructure and the corresponding change of its Fermi level. Voltage tuning of RKKY interaction may enable the next generation of switchable spintronics between antiferromagnetic and ferromagnetic modes with both fundamental and practical perspectives.
Aerosol effects on cloud water amounts were successfully simulated by a global cloud-system resolving model
Authors: Sato Yousuke , Goto Daisuke , Michibata Takuro , Suzuki Kentaroh , Takemura Toshihiko , Tomita Hirofumi , Nakajima Teruyuki 
Published: March 2018

AbstractAerosols affect climate by modifying cloud properties through their role as cloud condensation nuclei or ice nuclei, called aerosol–cloud interactions. In most global climate models (GCMs), the aerosol–cloud interactions are represented by empirical parameterisations, in which the mass of cloud liquid water (LWP) is assumed to increase monotonically with increasing aerosol loading. Recent satellite observations, however, have yielded contradictory results: LWP can decrease with increasing aerosol loading. This difference implies that GCMs overestimate the aerosol effect, but the reasons for the difference are not obvious. Here, we reproduce satellite-observed LWP responses using a global simulation with explicit representations of cloud microphysics, instead of the parameterisations. Our analyses reveal that the decrease in LWP originates from the response of evaporation and condensation processes to aerosol perturbations, which are not represented in GCMs. The explicit representation of cloud microphysics in global scale modelling reduces the uncertainty of climate prediction.
Batch production of 6-inch uniform monolayer molybdenum disulfide catalyzed by sodium in glass
Authors: Yang Pengfei , Zou Xiaolong , Zhang Zhepeng , Hong Min , Shi Jianping , Chen Shulin , Shu Jiapei , Zhao Liyun , Jiang Shaolong , Zhou Xiebo , Huan Yahuan , Xie Chunyu , Gao Peng , Chen Qing , Zhang Qing , Liu Zhongfan , Zhang Yanfeng 
Published: March 2018

AbstractMonolayer transition metal dichalcogenides (TMDs) have become essential two-dimensional materials for their perspectives in engineering next-generation electronics. For related applications, the controlled growth of large-area uniform monolayer TMDs is crucial, while it remains challenging. Herein, we report the direct synthesis of 6-inch uniform monolayer molybdenum disulfide on the solid soda-lime glass, through a designed face-to-face metal-precursor supply route in a facile chemical vapor deposition process. We find that the highly uniform monolayer film, with the composite domains possessing an edge length larger than 400 µm, can be achieved within a quite short time of 8 min. This highly efficient growth is proven to be facilitated by sodium catalysts that are homogenously distributed in glass, according to our experimental facts and density functional theory calculations. This work provides insights into the batch production of highly uniform TMD films on the functional glass substrate with the advantages of low cost, easily transferrable, and compatible with direct applications.
Shallow very-low-frequency earthquakes accompany slow slip events in the Nankai subduction zone
Authors: Nakano Masaru , Hori Takane , Araki Eiichiro , Kodaira Shuichi , Ide Satoshi 
Published: March 2018

AbstractRecent studies of slow earthquakes along plate boundaries have shown that tectonic tremor, low-frequency earthquakes, very-low-frequency events (VLFEs), and slow-slip events (SSEs) often accompany each other and appear to share common source faults. However, the source processes of slow events occurring in the shallow part of plate boundaries are not well known because seismic observations have been limited to land-based stations, which offer poor resolution beneath offshore plate boundaries. Here we use data obtained from seafloor observation networks in the Nankai trough, southwest of Japan, to investigate shallow VLFEs in detail. Coincident with the VLFE activity, signals indicative of shallow SSEs were detected by geodetic observations at seafloor borehole observatories in the same region. We find that the shallow VLFEs and SSEs share common source regions and almost identical time histories of moment release. We conclude that these slow events arise from the same fault slip and that VLFEs represent relatively high-frequency fluctuations of slip during SSEs.