bluuebunny/crossref_metadata_2025_split huggingface dataset:
(Big) Society and (Market) Discipline: Social Investment and the Financialisation of Social Reproduction
Authors: Harvie David 
Published: March 2019

Abstract
The United Kingdom is at the forefront of a global movement to establish a social-investment market. At the heart of social investment we find finance – and financialisation. Specifically, we find: a financial market (the social-investment market); a series of financial institutions (Big Society Capital, for example); a financial instrument (the social-impact bond); and a financial practice (social investing). Focusing on the UK, given its pioneering role, this paper first provides a brief history of social investment, tracing its development from the politics of the ‘Third Way’ to the social-impact bond. It then maps the terrain of the social-investment market, explaining the main institutions and actors, and the social-impact bond. Finally, it proposes a framework for analysing the disciplinary logics of finance, which it uses to understand the promise or threat (depending on one’s perspective) of social investment and the social-investment market.
The Great Armenian Flight: Migration and Cultural Change in the Seventeenth-Century Ottoman Empire
Authors: Shapiro Henry R. 
Published: March 2019

Abstract
The seventeenth century was a turning-point in the cultural and demographic history of the Ottoman Empire. Beginning in the late sixteenth century, Ottoman-Armenian subjects began to flee en masse from the Celali Revolts, war with Persia, and famine in Eastern Anatolia to more secure territories in Western Anatolia, Istanbul, and Thrace. This article documents the arrival of Armenian refugees in Thrace using Ottoman Turkish court records from the coastal town of Rodosto (Tekirdağ). After describing the micro-history of an Armenian refugee crisis, this article suggests that these migrations played a catalyzing role in the rise of a distinct “Western Armenian” culture and society, which developed for the first time in the seventeenth-century Ottoman Empire. The rise of this new society was an event of great importance in Ottoman history, as the Armenians would become a critical part of Ottoman economic and cultural life in the empire’s coastal trade cities.
Transcultural Fights: Fortification in Southeast Asian Seas during the Eighteenth Century
Authors: Luengo Pedro 
Published: March 2019

Abstract
Defensive architecture in Southeast Asian port cities during the eighteenth century is a topic never addressed from a transnational perspective. This paper aims to analyze it as a phenomenon of scientific transfer, considering fortifications as a remarkable example of “open air science.” First, it shows the complex situation among antagonistic powers in the Malay and South China seas. From here, it aims to identify the connections between Dutch and Spanish proposals in the area. One model focused on protecting sea routes, while the other was more concerned about maintaining territorial integrity. Later, it considers how local kingdoms from China or Siam to the southern sultanates addressed the problem. Here, a variety of answers have been found, ranging from a complete rejection of European solutions to qualified adaptations and wholesale adoption of them. From all these examples, it is possible to evaluate the nature of technical transfer in a transnational perspective.
Modal Decomposition of the Global Response to Tropical Heating Perturbations Resembling MJO
Authors: Kosovelj Katarina , Kucharski Fred , Molteni Franco , Žagar Nedjeljka 
Published: March 2019

AbstractThe paper presents four ensembles of numerical experiments that compare the response to monopole and dipole heating perturbations resembling different phases of the Madden–Julian oscillation (MJO). The results quantify the Rossby and inertio-gravity (IG) wave response using the normal-mode function decomposition. The day 3 response is characterized by about 60% variance in the IG modes, with about 85% of it belonging to the Kelvin waves. On day 14, only 10% of the response variance is due to the Kelvin waves. Although the n = 1 Rossby mode is the main contributor to the Rossby variance at all time scales, the n > 1 Rossby modes contribute over 50% of the balanced response to the MJO heating. In the short range, dipole perturbations produce a response with the maximal variance in zonal wavenumbers k = 2–3 whereas in the medium range the response maximizes at k = 1 in all experiments. Furthermore, the medium-range response to the heating perturbation mimicking MJO phase 6 is found also over Europe.
Mechanisms of Northward-Propagating Intraseasonal Oscillation over the South China Sea during the Pre-Monsoon Period
Authors: Zheng Bin , Huang Yanyan 
Published: March 2019

AbstractIn the present study, the spatiotemporal structures of the northward-propagating intraseasonal oscillation (ISO) over the South China Sea (SCS) in the premonsoon period are analyzed by using the TropFlux air–sea flux and the JRA-55 reanalysis datasets. It is found that the SCS ISO is significant in the premonsoon season with a strong component of the northward propagation and that the mean state is different from that of summertime. Moreover, there are similar structures to those of a boreal summer ISO event except for the perturbation vorticity with no obvious phase leading. An internal atmospheric dynamics mechanism is proposed to understand the cause of the northward propagation of the ISO during the premonsoon period based on the spatial and temporal structures of the ISOs. The key process associated with this mechanism is the barotropic vorticity advection by the mean barotropic southerly winds, and the main barotropic vorticity around the convection center can be induced by the vertical advection of the mean vorticity. Low-level moisture convergence caused by anomalous flow is a supplementary mechanism to drive the ISOs northward during the premonsoon period, particularly over the northern SCS. In this mechanism, the SST-induced wind anomalies play a more important role than the convection-induced wind anomalies. The summer monsoon circulation has not built up during the premonsoon period, and thus the vertical wind shear effect and the barotropic vorticity effect associated with the meridional advection of baroclinic vorticity are not essential to cause the northward propagation of the ISOs over the SCS.
Contributions of SST Anomalies in the Indo-Pacific Ocean to the Interannual Variability of Tropical Cyclone Genesis Frequency over the Western North Pacific
Authors: Zhan Ruifen , Wang Yuqing , Zhao Jiuwei 
Published: March 2019

AbstractThis study attempts to evaluate quantitatively the contributions of sea surface temperature (SST) anomalies in the Indo-Pacific Ocean to the interannual variability of tropical cyclone (TC) genesis frequency (TCGF) over the western North Pacific (WNP). Three SST factors in the Indo-Pacific Ocean are found to play key roles in modulating the interannual variability of WNP TCGF. They are summer SST anomaly in the east Indian Ocean (EIO), the summer El Niño–Southern Oscillation Modoki index (EMI), and the spring SST gradient (SSTG) between the southwestern Pacific and the western Pacific warm pool. Results show that the three factors together can explain 72% of the total variance of WNP TCGF in the typhoon season for the period 1980–2015. Among them, the spring SSTG and the summer EIO contribute predominantly to the interannual variability of TCGF, followed by the summer EMI, with respective contributions being 39%, 38%, and 23%. Further analysis shows that the summer EMI was affected significantly by the spring SSTG and thus had a relatively lower contribution to the TCGF than the spring SSTG. In addition, a statistical model is constructed to predict the WNP TCGF in the typhoon season by a combination of the May EIO and the spring SSTG. The new model can reproduce well the observed WNP TCGF and shows an overall better skill than the ECMWF Seasonal Forecasting System 5 (SEAS5) hindcasts. This statistical model provides a good tool for seasonal prediction of WNP TCGF.
Catheter-directed thrombolysis vs. anticoagulation for the prevention and treatment of post-thrombotic syndrome in deep vein thrombosis: An updated systematic review and meta-analysis of randomized trials
Authors: Mastoris Ioannis , Kokkinidis Damianos G , Bikakis Iosif , Archontakis-Barakakis Paraschos , Papanastasiou Christos A , Jonnalagadda Anil Kumar , Schizas Dimitrios , Bakoyiannis Christos , Palaiodimos Leonidas , Faillace Robert T 
Published: March 2019

Background Oral anticoagulation therapy was the mainstay of deep vein thrombosis treatment but recently, catheter-directed thrombolysis has emerged as an alternative. Objective To compare the efficacy and safety of the two strategies. Methods Medline, Embase and Cochrane CENTRAL were reviewed. Outcomes of interest included post-thrombotic syndrome, thromboembolic events, mortality, bleeding risk and iliofemoral patency. A random effects model meta-analysis was performed. Heterogeneity was assessed with I square. Results Four randomized controlled trials (RCTs) including 1005 patients met the inclusion criteria. Catheter-directed thrombolysis was more likely to prevent overall post-thrombotic syndrome compared to anticoagulation only (OR: 0.32; 95% CI: 0.12–0.85; I2=87.2%), and to lead to iliofemoral vein patency (OR: 2.7; 95% CI: 1.08–6.75; I2=55.3%) but no difference was noted in thromboembolic events (OR = 0.5; 95% CI: 0.08–3.02, I2=55.1%), bleeding and mortality rates. Conclusions Catheter-directed thrombolysis can decrease post-thrombotic syndrome rates and improve iliofemoral vein patency compared to anticoagulation when used for the treatment of deep vein thrombosis.
Lidocaine safety after saphenous vein tumescent anesthesia
Authors: Wright Thomas F , Brunetti Giulietta F , Kennedy Patrick 
Published: March 2019

Objectives For endovenous thermal ablation of the saphenous veins, tumescent lidocaine anesthesia is often used. Unfortunately, information is sparse on the pharmacokinetics of lidocaine absorption and its maximum safe dose. The aim of this study was to evaluate plasma concentration of lidocaine on 12 lead electrocardiograms (ECGs) and symptoms over time after the administration of tumescent lidocaine during endovenous thermal ablation procedures in healthy volunteers. Methods An observational study of symptoms, 12 lead ECGs, and serum lidocaine levels were obtained following the administration of either 15 mg/kg lidocaine or 35 mg/kg lidocaine in the perivenous saphenous space under ultrasound guidance. Blood was drawn at regular intervals in heparinized tubes and spun at 3000 r/min for 10 min. The plasma lidocaine levels were plotted vs. time for statistical comparisons. Results With the 35 mg/kg dose, four of 11 participants developed symptoms of lidocaine toxicity at 40 min, which resolved by 180 min. The 35 mg/kg dose resulted in a mean serum lidocaine peak of 2.55 µg/ml at 60 min. The 15 mg/kg dose did not result in any symptoms of lidocaine toxicity, and it resulted in a serum lidocaine plateau of 0.85 µg/ml at 180 min. No significant changes were seen on the 12-lead ECG after the administration of lidocaine at either dose. Conclusions The 15 mg/kg total lidocaine dose did not cause symptoms and appears to be a safe lidocaine dosage for tumescent anesthesia for saphenous endovenous thermal ablations. The 35 mg/kg lidocaine dose is associated with lidocaine toxicity. More study on the maximal safe dose of lidocaine for endovenous thermal ablations is needed.
Priorities for Supportive Housing Services: Perspectives of People With Mental Illness in Northeastern Ontario
Authors: Montgomery Phyllis , Mossey Sharolyn , McCauley Karen 
Published: March 2019

Background Accessible, appropriate, and affordable housing is recognized as essential for the well-being of all Canadians. Securing and maintaining housing tenure for individuals living with chronic health and social challenges can be compromised without appropriate services. There has been limited research into the priorities to enhance supportive housing services from the perspective of individuals living with mental illness in smaller urban and rural communities. Purpose The purpose was to describe the priorities for supportive housing from the viewpoints of tenants recovering from mental illness in northeastern Ontario. Methods This descriptive study used Q methodology to engage 52 adults regarding their impressions about enhancing supportive housing services. Participants ranked 39 housing and support priority statements on a nine-point Likert-type scale. Results Four discrete viewpoints about priorities for supportive housing were building a home, letting others in, moving outside the walls, and accessing personalized services. Common across these viewpoints was the need to increase financial assistance offered through existing programs. Conclusions Fostering individual pathways to recovery involves mitigating health and social disparities, relative to supportive housing, one size does not fit all. Service providers and decision makers are compelled to situate each individual within an evidence-informed supportive housing system for citizenship.
Prognostic Values of Platelet-Associated Indicators in Resectable Lung Cancers
Authors: Wang Jing-Jing , Wang Yin-Ling , Ge Xin-Xin , Xu Meng-Dan , Chen Kai , Wu Meng-Yao , Gong Fei-Ran , Tao Min , Wang Wen-Jie , Shou Liu-Mei , Li Wei 
Published: March 2019

Background: Lung cancer is the leading cause of cancer death. Platelet-related indictors, including platelet count, plateletcrit, mean platelet volume, and platelet distribution width, not only associate with morphology and functions of platelet but also correlate with tumor development and metastasis. In the present study, we investigated the values of platelet-related indictors in the prognosis evaluation of resectable lung cancers. Methods: In total, 101 patients with resectable lung cancer were recruited in this study. Patients were divided into 2 groups according to the median pretreatment values. To evaluate the individual value changes after treatment, we introduced the concept of post-/pretreatment ratio (≤1 indicated value was not increased after treatment, while >1 suggested increased value). Results: The high pretreatment platelet count level was correlated with larger tumor size. High pretreatment plateletcrit level was associated with more lymph nodes metastasis. Patients with high pretreatment plateletcrit level had worse overall survival, whereas pretreatment platelet count, mean platelet volume, and platelet distribution width levels were not correlated with outcomes. Surgery had no impact on the values of platelet count, plateletcrit, mean platelet volume, or platelet distribution width. Adjuvant chemotherapy significantly decreased the values of platelet count and plateletcrit, whereas it had no effect on the values of mean platelet volume or platelet distribution width. Whole course of treatment (surgery combined with adjuvant chemotherapy) significantly decreased the values of platelet count and platelet distribution width, whereas it had no effect on the values of plateletcrit or mean platelet volume. Post-/pretreatment platelet count, plateletcrit, mean platelet volume, and platelet distribution width ratios were not correlated with outcomes. Univariate analyses demonstrated that American Joint Committee on Cancer stage and pretreatment plateletcrit level were significant risk factors for prognosis. Cox regression analysis revealed that no factor independently associated with worse survival. Conclusion: Pretreatment plateletcrit level could be a potential prognostic factor in resectable lung cancers.
Early Discharge Does Not Increase Readmission Rates After Minimally Invasive Anatomic Lung Resection
Authors: Chevrollier Guillaume S. , Nemecz Amanda K. , Devin Courtney , Go Kendrick V. , Yi Misung , Keith Scott W. , Cowan Scott W. , Evans Nathaniel R. 
Published: March 2019

Objective Enhanced recovery pathways reduce length of stay and costs following lung resection. However, many fear that early discharge may lead to increased hospital readmissions. In this study, we aimed to determine whether early discharge was associated with increased readmission following anatomic lung resection. Methods Using the lung resection database approved by our institutional review board, we identified all patients undergoing minimally invasive lobectomy and segmentectomy between January 2010 and March 2017 at our institution, where an enhanced recovery pathway is well established. Thirty-day readmissions were compared between patients with short- and average length of stay, defined as 1 to 2 days and 3 to 5 days, respectively. Multivariable logistic regression analysis of patients matched by propensity scores was performed to determine odds of 30-day readmission for each group. Significance was set at P < 0.05. Results A total of 296 patients met inclusion criteria. Unadjusted analysis revealed a 3-fold increased rate of readmission in the group with average length of stay (9%, n = 12) versus the group with short length of stay (3%, n = 5; P < 0.01). At baseline, patients with average length of stay had increased rates of preoperative chemotherapy (13%, n = 18 vs. 4%, n = 6; P < 0.01) and radiation (12%, n = 16 vs. 3%, n = 5). Patients with average length of stay also had higher rates of lobectomy (95%, n = 127 vs. 86%, n = 140; P = 0.02) and postoperative complications (31%, n = 41 vs. 4%, n = 7; P < 0.01). On multivariable analysis, patients with average length of stay had a 2.3-fold greater odds of readmission, which was not statistically significant (OR = 2.33; 95% CI, 0.60 to 9.02; P = 0.22). Conclusions Early discharge following minimally invasive anatomic lung resection does not increase the risk of hospital readmission in patients treated within an enhanced recovery pathway.
The effect of TEVAR for blunt traumatic thoracic aortic injury on maximal aortic diameter: Mid- and long-term outcome
Authors: Mufty Hozan , Maleux Geert , Houthoofd Sabrina , Cornelissen Sandra A , Daenens Kim , Bonne Lawrence , Fourneau Inge 
Published: March 2019

Objective Thoracic endovascular aortic repair (TEVAR) has become the standard of care for blunt thoracic aortic injury (BTAI). Long-term effects of TEVAR on the aortic diameter are not well studied. This study evaluates the effect of TEVAR for BTAI on the aortic diameter in mid- and long-term follow-up. Methods All patients treated with TEVAR for BTAI between August 2000 and May 2016 were included. Maximum aortic diameter was measured at four predetermined thoracic aortic levels in the preoperative and first postoperative CT angiography (CTa) and in the last control CTa or MR angiography: 1 cm proximal (D1) and 1 cm distal to the left subclavian artery (D2), 3 cm distal to the left subclavian artery (D3) and 3 cm proximal to the celiac trunk (D4). Results A total of 27 patients (20 men, mean age 40 years (±17.55) were included. Mean follow-up time was 90 months (±48.36)). No re-interventions were needed. Mean growth of aortic diameter at level D1, D2, D3 and D4 was 0.22 mm ± 3.66, 1.79 mm ± 3.82, 0.73 mm ± 4.18 and –1.06 mm ± 2.82, respectively, when comparing last follow-up to the preoperative imaging without any statistical significant differences. When comparing the preoperative diameter with the first postoperative CT, only a statistical significant growth of 2.81 mm ± 2.69 was seen at level of D2 ( p < 0.05) Conclusion During mid- to long-term follow-up, a temporary significant increase of the maximum aortic diameter was seen at level D2 in the direct postoperative phase This increase was not associated with clinical events and suggests long-term efficacy of TEVAR after BTAI.
lloprost delivered via the BREELIBTM nebulizer: a review of the clinical evidence for efficacy and safety
Authors: Gessler Tobias 
Published: March 2019

Inhaled iloprost is a well-established medication to treat pulmonary arterial hypertension (PAH), a serious and potentially fatal disease of the pulmonary resistance vessels. The therapeutic administration of iloprost requires six to nine inhalations per day, due to the short biological half-life of this prostacyclin analogue. The I-NebTM AADTM, introduced in 2006, is the most commonly used nebulizer for delivering iloprost, requiring at least 6.5 min for an inhaled dose of 5 µg. In order to reduce inhalation time, a portable nebulizer based on modern-device technology was developed. The acute safety and tolerability of rapid iloprost inhalation via the BREELIBTM nebulizer was assessed in a four-part clinical trial. In this review, I describe the rationale and features of the new nebulizer, with particular emphasis on the safety and tolerability profile of iloprost inhalation via BREELIBTM observed in the first clinical studies. Meanwhile, the BREELIBTM nebulizer is approved and available for inhaled iloprost therapy combining significantly reduced inhalation time with good tolerability. This new approach will certainly improve patient convenience and compliance, possibly resulting in broader acceptance and improved efficacy of iloprost aerosol therapy in PAH. The reviews of this paper are available via the supplementary material section.
The Comparation of Intraperitoneal Injection and Nasal-only Delivery Allergic Rhinitis Model Challenged With Different Allergen Concentration
Authors: Wang Ying , Zhou Yue , Zhu Yun , Yu Wenting , Wang Jinghui , Fu Junmei , Yuan Yang , Yu Zizhong , Chen Shan , Wang Yanjun , Chen Jianjun , Kong Weijia 
Published: March 2019

Background Predominantly, 2 animal models are used for allergic rhinitis (AR), which are established by intraperitoneal (IP) injection plus local challenge and nasal-only delivery. The differences between these 2 models are not fully understood. Moreover, dose–response relationship to allergens remains unclear. Methods In this study, mice were sensitized by nasal drops (without adjuvant, once daily for 9 weeks) to set up a nasal-only delivery AR model. Five different doses of ovalbumin (OVA) nasal drops were served to explore the dose–response to allergens. Allergic symptoms, serum antibodies (IgE, IgG2a, and IgG1), spleen supernatant and nasal lavage fluid (NALF) cytokines (IL-4, IL-5, and IFN-r), and infiltrated eosinophils of the nasal mucosa were observed. Results The allergic symptoms, serum antibodies, cytokines, and infiltrated eosinophils were significantly higher in the high OVA concentration compared with those of the control group. Different OVA concentrations associated with the severity of allergy. Within a certain concentration range, OVA concentration positively related to the severity of symptoms, IgE antibody level, and Th2 bias. Meanwhile, serum antibodies (IgE and IgG1) and cytokines (IL-4, IL-5 in spleen and IL-4 in NALF) were significantly higher in the classical IP injection group than in the nasal drip groups. Conclusion The IP injection model and the nasal-only delivery model are 2 typical models for AR that causes a different immune response. A positive dose–response relationship in the nasal-only delivery model is observed from 25 mg/mL to 0.025 mg/mL.