bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late Quaternary Eruption Record and Probability of Future Volcanic Eruptions in the Long Valley Volcanic Region (CA, USA)
Authors: Bevilacqua Andrea , Bursik Marcus , Patra Abani , Bruce Pitman E. , Yang Qingyuan , Sangani Radhika , Kobs‐Nawotniak Shannon 
Published: June 2018

AbstractThe Long Valley volcanic region, eastern California, has been characterized by recurrent and generally explosive eruptions in the past 180,000 years, originating from a N/S elongated area ~50 km in extent, including the Mammoth Mountain lava dome complex, the Mono‐Inyo volcanic chain, and their peripheries. Several temporal clusters of activity have been observed in a relatively well‐preserved time‐stratigraphic record, which is nevertheless affected by uncertainties. This study has two main objectives: (1) to fully describe the past eruption record by using a stochastic model capable of combining radiometric ages and stratigraphic constraints and, (2) based on the uncertainty assessment, to develop a doubly stochastic, long‐term temporal model based on the current situation. Multiple approaches are described and compared, and multimodel forecasts are also presented. Our findings provide fundamental information for hazard assessment and forecasting of the next eruption in the Long Valley volcanic region, of which the mean probability of occurrence is estimated to be ~2.5% in the next 10 years and ~22.5% in the next 100 years.
Can We Model the Effect of Observed Sea Level Rise on Tides?
Authors: Schindelegger M. , Green J. A. M. , Wilmes S.‐B. , Haigh I. D. 
Published: June 2018

AbstractThe link between secular changes in the lunar semidiurnal ocean tide (M2) and relative sea level rise is examined based on numerical tidal modeling and the analysis of long‐term sea level records from Europe, Australia, and the North American Atlantic coasts. The study sets itself apart from previous work by using a 1/12° global tide model that incorporates the effects of self‐attraction and loading through time‐step‐wise spherical harmonic transforms instead of iteration. This novel self‐attraction and loading implementation incurs moderate computational overheads (some 50%) and facilitates the simulation of shelf sea tides with a global root mean square error of 14.6 cm in depths shallower than 1,000 m. To reproduce measured tidal changes in recent decades, the model is perturbed with realistic water depth changes, compiled from maps of altimetric sea level trends and postglacial crustal rebound. The M2 response to the adopted sea level rise scenarios exhibits peak sensitivities in the North Atlantic and many marginal seas, with relative magnitudes of 1–5% per century. Comparisons with a collection of 45 tide gauge records reveals that the model reproduces the sign of the observed amplitude trends in 80% of the cases and captures considerable fractions of the absolute M2 variability, specifically for stations in the Gulf of Mexico and the Chesapeake‐Delaware Bay system. While measured‐to‐model disparities remain large in several key locations, such as the European Shelf, the study is deemed a major step toward credible predictions of secular changes in the main components of the ocean tide.
Future Changes of Wind Speed and Wind Energy Potentials in EURO‐CORDEX Ensemble Simulations
Authors: Moemken Julia , Reyers Mark , Feldmann Hendrik , Pinto Joaquim G. 
Published: June 2018

AbstractRenewable energy production is strongly influenced by weather and climate. Regional climate projections can be useful to quantify climate change impacts on renewable energies. With this aim, we analyze future changes of wind speed and wind energy potentials using a multimodel ensemble of EURO‐CORDEX simulations at 12 km and three‐hourly resolution, considering nine different global and regional climate model chains. A comparison between modeled historical 10 m wind speeds and ERA‐Interim‐driven evaluation runs for the same regional climate models uncovers some substantial model biases. The bias‐corrected 10 m wind speeds are extrapolated to the hub height of a wind turbine to derive gridded wind energy output (Eout). The ensemble mean responses project only small changes of mean annual and winter Eout for large parts of Europe in future decades, but a considerable decrease for summer Eout. In terms of variability, increasing intraannual and interdaily variabilities are projected for large parts of northern, central, and eastern Europe. While the ensemble spread is quite large for interdaily variability, results are more robust for intraannual variability. With respect to wind speed characteristics relevant for wind energy production, a robust increase in the occurrence of low wind speeds (<3 m/s) is detected. Due to a combination of higher annual mean Eout and lower intraannual variability, climate change could be beneficial for regions like Baltic and Aegean Sea. For large parts of Germany, France, and Iberia, a lower mean Eout and increased intraannual variability may imply larger temporal/spatial fluctuations in future wind energy production and therefore a more challenging wind energy management.
Cost-Savings Analysis of Primary Care Behavioral Health in a Pediatric Setting: Implications for Provider Agencies and Training Programs
Authors: Dopp Alex R. , Smith Allison B. , Dueweke Aubrey R. , Bridges Ana J. 
Published: June 2018

This study investigated economic savings associated with primary care behavioral health (PCBH) in a diverse sample of 248 pediatric patients seen at a Federally Qualified Health Center. We sought to determine the (a) overall cost savings from PCBH and (b) incremental costs and savings of services provided by doctoral trainees versus full-time behavioral health employees (BHEs). Data were extracted from patient medical records for the 2015–2016 training year. We calculated the per-patient costs for BHEs ( n = 5; served 223 patients) and trainees ( n = 2; served 25 patients) from administrative data. Savings associated with PCBH were computed based on reductions in monthly health care charges after versus before the initial PCBH visit for each patient. There was a significant reduction in health care charges after an initial PCBH visit, with an overall (i.e., average across provider types) net savings of $38 per patient. Stated differently, each dollar spent on PCBH returned approximately $1.16 in reduced health care charges. There was no significant difference in cost-savings between BHEs and trainees. Uncertainty in several key study parameters (i.e., BHE salary, changes in health charges) may have influenced the results. These findings suggest that PCBH services with pediatric patients hold promise in terms of economic sustainability, including when trainees are involved in service delivery. Implications of the study findings for policymakers, provider agencies, and doctoral training programs in psychology are discussed. Implications for Impact Statement This study suggests that including social workers and psychology trainees in pediatric primary care services can result in savings on overall health care expenses. Trainees showed promise in producing the same savings as full-time employees.
Sustaining Integrated Behavioral Health Practice Without Sacrificing the Continuum of Care
Authors: Herbst Rachel Becker , Margolis Kathryn L. , McClellan Brigitte B. , Herndon Jason L. , Millar Amanda M. , Talmi Ayelet 
Published: June 2018

This article describes how an innovative model of practice transformation, used by 4 integrated pediatric primary care practices over a 2 year grant period, promoted the practice of integrated primary care (IPC) behavioral health services. Practice transformation was possible through the implementation of an alternative billing strategy to enhance sustainability, effective utilization of clinical productivity to provide meaningful patient services, and the identification of strategies to further the practice of IPC. Specifically, we provide: (a) a description of the diversity of billing strategies typically used by pediatric practices utilizing integrated care and how those strategies are impacted by state health care policies; (b) a description of the grant, including the service delivery model, implementation phase, and data collection procedures; (c) results of implementation and billing/reimbursement data that were collected across the 4 practices; (d) an analysis of how billing strategies are critical in defining implementation strategies within pediatric integrated care; and (e) lessons learned about how billing strategies must be flexible and amenable to change over time to stay current with ever-changing health care policies and reimbursement models. Implications for Impact Statement This article describes how an innovative model of practice transformation, used by 4 integrated pediatric primary care practices over a 2 year grant period, promoted the practice of integrated behavioral health services in primary care. We provide lessons learned about financing primary care using innovative billing strategies beyond the use mental health diagnoses and billing codes, which enable psychologists to focus more on preventative and health behavior change services.
An Introduction to Cost-Effectiveness Acceptability Curves
Authors: Yarbro Jessica L. , McKnight Patrick E. 
Published: June 2018

Recent changes to health care reimbursement and funding have made cost-effectiveness analyses more relevant for pediatric psychologists. Evaluating and presenting uncertainty around cost-effectiveness estimates is important for proper reporting of results and represents one area where pediatric psychologists may have limited training. This article seeks to address this gap by providing pediatric psychologists with an introduction to cost-effectiveness acceptability curves (CEACs), a method for reporting and presenting uncertainty that is consistent with the Consolidated Health Economic Evaluation Reporting Standards. Using practical examples, we provide information about how CEACs are constructed and interpreted. By supporting a greater understanding about uncertainty in cost-effective estimates, we hope that this article aids pediatric psychologists in their production and consumption of cost-effectiveness research. Implications for Impact Statement Cost-effectiveness analyses represent a complex topic that is increasingly relevant for pediatric psychologists. The article provides an overview of cost-effectiveness acceptability curves, which are one method for presenting the results of a cost-effectiveness analysis. Understanding these analyses will help pediatric psychologists better advocate for continued reimbursement of their services.
Mechanically reconfigurable architectured graphene for tunable plasmonic resonances
Authors: Kang Pilgyu , Kim Kyoung-Ho , Park Hong-Gyu , Nam SungWoo 
Published: June 2018

AbstractGraphene nanostructures with complex geometries have been widely explored for plasmonic applications, as their plasmonic resonances exhibit high spatial confinement and gate tunability. However, edge effects in graphene and the narrow range over which plasmonic resonances can be tuned have limited the use of graphene in optical and optoelectronic applications. Here we present a novel approach to achieve mechanically reconfigurable and strongly resonant plasmonic structures based on crumpled graphene. Our calculations show that mechanical reconfiguration of crumpled graphene structures enables broad spectral tunability for plasmonic resonances from mid- to near-infrared, acting as a new tuning knob combined with conventional electrostatic gating. Furthermore, a continuous sheet of crumpled graphene shows strong confinement of plasmons, with a high near-field intensity enhancement of ~1 × 104. Finally, decay rates for a dipole emitter are significantly enhanced in the proximity of finite-area biaxially crumpled graphene flakes. Our findings indicate that crumpled graphene provides a platform to engineer graphene-based plasmonics through broadband manipulation of strong plasmonic resonances.
Microcavity electrodynamics of hybrid surface plasmon polariton modes in high-quality multilayer trench gratings
Authors: Liu Xiaoyi , Gao Jinbo , Gao Jinsong , Yang Haigui , Wang Xiaoyi , Wang Tongtong , Shen Zhenfeng , Liu Zhen , Liu Hai , Zhang Jian , Li Zizheng , Wang Yanchao , Li Qiang 
Published: June 2018

AbstractIn common plasmonic structures, absorption and radiation losses are often mutually restricted and can seriously influence the device performance. The current study presents a compound structure composed of multilayer grating stripes and multilayer shallow trenches. A small depth was adopted for the trench configuration to exclude the extra bend loss. These two sections supported Fabry–Perot resonance and cavity modes, respectively, with hybrid modes formed through intercoupling. In addition, the total loss for the entire framework was clearly reduced due to the introduction of the trench geometry, indicating that both absorption and radiation losses were successfully taken into consideration in the compound structure. Significantly, such a low loss realized by the hybridization of surface plasmon polariton modes has rarely been seen before. Moreover, the debatable relationship between the total and partial quality factors was described for the first time based on a hybrid mode analysis to establish a new approach to investigate the different resonance modes. In the detailed calculation process, the relative electric field intensity was first adopted to stipulate the effective areas for the various modes, which is more reasonable than using the common definition that is based on a unit structure. The multilayer trench grating exhibited a relatively low loss without weakening energy localization, which is significant in the design of plasmonic devices.
Cocaine engages a non-canonical, dopamine-independent, mechanism that controls neuronal excitability in the nucleus accumbens
Authors: Delint-Ramirez Ilse , Garcia-Oscos Francisco , Segev Amir , Kourrich Saïd 
Published: June 2018

AbstractDrug-induced enhanced dopamine (DA) signaling in the brain is a canonical mechanism that initiates addiction processes. However, indirect evidence suggests that cocaine also triggers non-canonical, DA-independent, mechanisms that contribute to behavioral responses to cocaine, including psychomotor sensitization and cocaine self-administration. Identifying these mechanisms and determining how they are initiated is fundamental to further our understanding of addiction processes. Using physiologically relevant in vitro tractable models, we found that cocaine-induced hypoactivity of nucleus accumbens shell (NAcSh) medium spiny neurons (MSNs), one hallmark of cocaine addiction, is independent of DA signaling. Combining brain slice studies and site-directed mutagenesis in HEK293T cells, we found that cocaine binding to intracellular sigma-1 receptor (σ1) initiates this mechanism. Subsequently,σ1 binds to Kv1.2 potassium channels, followed by accumulation of Kv1.2 in the plasma membrane, thereby depressing NAcSh MSNs firing. This mechanism is specific to D1 receptor-expressing MSNs. Our study uncovers a mechanism for cocaine that bypasses DA signaling and leads to addiction-relevant neuroadaptations, thereby providing combinatorial strategies for treating stimulant abuse.
Biogeographic patterns of abundant and rare bacterioplankton in three subtropical bays resulting from selective and neutral processes
Authors: Mo Yuanyuan , Zhang Wenjing , Yang Jun , Lin Yuanshao , Yu Zheng , Lin Senjie 
Published: June 2018

Abstract
Unraveling the relative importance of ecological processes regulating microbial community structure is a central goal in microbial ecology. Here, we used high-throughput sequencing to examine the relative contribution of selective and neutral processes in the assembly of abundant and rare subcommunities from three subtropical bays of China. We found that abundant and rare bacterial taxa were distinctly different in diversity, despite the similar biogeographic patterns and strong distance-decay relationships, but the dispersal of rare bacterial taxa was more limited than that of abundant taxa. Furthermore, the environmental (selective processes) and spatial (neutral processes) factors seemed to govern the assembly and biogeography of abundant and rare bacterial subcommunities, although both factors explained only a small fraction of variation within the rare subcommunity. More importantly, variation partitioning (based on adjusted R2 in redundancy analysis) showed that spatial factors exhibited a slightly greater influence on both abundant and rare subcommunities compared to environmental selection; however, the abundant subcommunity had a much stronger response to spatial factors (17.3% of pure variance was explained) than that shown by the rare bacteria (3.5%). These results demonstrate that environmental selection and neutral processes explained the similar biogeographic patterns of abundant and rare subcommunities, but a large proportion of unexplained variation in the rare taxa (91.1%) implies that more complex assembly mechanisms may exist to shape the rare bacterial assemblages in the three subtropical bays.
Loss of Drosha underlies dopaminergic neuron toxicity in models of Parkinson’s disease
Authors: Wang Ronglin , Lu Fangfang , Zhu Gang , Feng Dayun , Nie Tiejian , Tao Kai , Yang Shaosong , Lei Jie , Huang Lu , Mao Zixu , Yang Qian 
Published: June 2018

AbstractMiRNAs, a group of powerful modulator of gene expression, participate in multiple cellular processes under physiological and pathological conditions. Emerging evidence shows that Drosha, which controls the initial step in canonical miRNA biogenesis, is involved in modulating cell survival and death in models of several diseases. However, the role of Drosha in Parkinson’s disease (PD) has not been well established. Here, we show that the level of Drosha decreases in 6-OHDA-induced cellular and animal models of PD. 6-OHDA induced a p38 MAPK-dependent phosphorylation of Drosha. This triggered Drosha degradation. Enhancing the level of Drosha protected the dopaminergic (DA) neurons from 6-OHDA-induced toxicity in both in vitro and in vivo models of PD and alleviated the motor deficits of PD mice. These findings reveal that Drosha plays a critical role in the survival of DA neurons and suggest that stress-induced destabilization of Drosha may be part of the pathological process in PD.
Histamine deficiency aggravates cardiac injury through miR-206/216b-Atg13 axis-mediated autophagic-dependant apoptosis
Authors: Ding Suling , Abudupataer Mieradilijiang , Zhou Zheliang , Chen Jinmiao , Li Hui , Xu Lili , Zhang Weiwei , Zhang Shuning , Zou Yunzeng , Hong Tao , Wang Timothy C. , Yang Xiangdong , Ge Junbo 
Published: June 2018

AbstractHistamine is a widely distributed biogenic amine involved in the regulation of an array of biological processes. Serum histamine level is markedly elevated in the early stages of acute myocardial infarction, whereas the role it plays remains unclear. Histidine decarboxylase (HDC) is the unique enzyme responsible for histamine production, and cardiac injury is significantly aggravated in HDC knockout mice (HDC−/−), in which histamine is deficient. We also observed that autophagy was highly activated in cardiomyocytes of HDC−/− mice post acute myocardial infarction (AMI), which was abolished by compensation of exogenous histamine. The in vivo and in vitro results showed that acting through histamine 1 receptor, histamine increased miR-206 and miR-216b, which worked in concert to target to Atg13, resulting in the reduction of autophagy activation under hypoxia and AMI condition. Further study revealed that Atg13 interacted with FADD to promote the activation of caspase-8 and cell apoptosis. Taken together, these data unveil a novel intracellular signaling pathway involved in histamine regulating myocardial autophagy and apoptosis under hypoxia and AMI condition, which might help to more comprehensively evaluate the usage of histamine receptor antagonists and to develop new therapeutic targets for myocardial infarction.
Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity
Authors: Guo Rui , Hua Yinan , Ren Jun , Bornfeldt Karin E. , Nair Sreejayan 
Published: June 2018

AbstractThe lysosomal cysteine protease Cathepsin K is elevated in humans and animal models of heart failure. Our recent studies show that whole-body deletion of Cathepsin K protects mice against cardiac dysfunction. Whether this is attributable to a direct effect on cardiomyocytes or is a consequence of the global metabolic alterations associated with Cathepsin K deletion is unknown. To determine the role of Cathepsin K in cardiomyocytes, we developed a cardiomyocyte-specific Cathepsin K-deficient mouse model and tested the hypothesis that ablation of Cathepsin K in cardiomyocytes would ameliorate the cardiotoxic side-effects of the anticancer drug doxorubicin. We used an α-myosin heavy chain promoter to drive expression of Cre, which resulted in over 80% reduction in protein and mRNA levels of cardiac Cathepsin K at baseline. Four-month-old control (Myh-Cre-; Ctskfl/fl) and Cathepsin K knockout (Myh-Cre+; Ctskfl/fl) mice received intraperitoneal injections of doxorubicin or vehicle, 1 week following which, body and tissue weight, echocardiographic properties, cardiomyocyte contractile function and Ca2+-handling were evaluated. Control mice treated with doxorubicin exhibited a marked increase in cardiac Cathepsin K, which was associated with an impairment in cardiac structure and function, evidenced as an increase in end-systolic and end-diastolic diameters, decreased fractional shortening and wall thickness, disruption in cardiac sarcomere and microfilaments and impaired intracellular Ca2+ homeostasis. In contrast, the aforementioned cardiotoxic effects of doxorubicin were attenuated or reversed in mice lacking cardiac Cathepsin K. Mechanistically, Cathepsin K-deficiency reconciled the disturbance in cardiac energy homeostasis and attenuated NF-κB signaling and apoptosis to ameliorate doxorubicin-induced cardiotoxicity. Cathepsin K may represent a viable drug target to treat cardiac disease.
The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death
Authors: Liu Ge , Wang Kai , Kuang Shan , Cao Ruobing , Bao Li , Liu Rui , Liu Hongwei , Sun Chaomin 
Published: June 2018

AbstractCancer cells rewire their metabolism to satisfy the demands of uncontrolled proliferation and survival. The reprogramming of lipid metabolism supports tumor growth, metastasis, and therapy-resistance. Therefore, targeting lipid metabolic reprogramming is a potential cancer treatment strategy. We recently isolated the novel natural triterpene GL22 from Ganoderma leucocontextum, a traditional Chinese medicine. Here, we show that GL22 significantly inhibits the growth of the liver cancer cell line Huh7.5 in vitro and of Huh7.5-derived tumor xenografts in vivo. We further find that GL22 induces mitochondrial dysfunction and cell death in Huh7.5 cells, in part due to fatty acid immobilization and loss of the mitochondrial lipid cardiolipin, which has vital structural and metabolic functions. Importantly, we demonstrate that GL22 treatment decreases the expression of fatty acid-binding proteins (FABPs), which likely underlies the loss of cardiolipin, mitochondrial dysfunction, and cell death. The over-expressions of FABPs prevented the GL22-induced cell death, loss of cardiolipin, decrease of ATP production, and reduction of oxygen consumption rate in Huh7.5 cells. Our results support targeting lipid metabolism via manipulating FABPs as a cancer treatment strategy, and promote Chinese medicine as an important source of novel anticancer drugs.