bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential regulation of TNL‐mediated immune signaling by redundant helper CNLs
Authors: Wu Zhongshou , Li Meng , Dong Oliver Xiaoou , Xia Shitou , Liang Wanwan , Bao Yongkang , Wasteneys Geoffrey , Li Xin 
Published: December 2018

Summary

Higher plants utilize nucleotide‐binding leucine‐rich repeat domain proteins (NLRs) as intracellular immune receptors to recognize pathogen‐derived effectors and trigger a robust defense. The Activated Disease Resistance 1 (ADR1) family of coiled‐coil NLRs (CNLs) have evolved as helper NLRs that function downstream of many TIR‐type sensor NLRs (TNLs). Close homologs of ADR1s form the N REQUIREMENT GENE 1 (NRG1) family in Arabidopsis, the function of which is unclear.

Through CRISPR/Cas9 gene editing methods, we discovered that the tandemly repeated NRG1A and NRG1B are functionally redundant and operate downstream of TNLs with differential strengths. Interestingly, ADR1s and NRG1s function in two distinct parallel pathways contributing to TNL‐specific immunity.

Synergistic effects on basal and TNL‐mediated defense were detected among ADR1s and NRG1s. An intact P‐loop of NRG1s is not required for mediating signals from sensor TNLs, whereas auto‐active NRG1A exhibits autoimmunity. Importantly, NRG1s localize to the cytosol and endomembrane network regardless of the presence of effectors, suggesting a cytosolic activation mechanism.

Taken together, different sensor TNLs differentially use two groups of helper NLRs, ADR1s and NRG1s, to transduce downstream defense signals.
How to avoid begging the question against evolutionary debunking arguments
Authors: Copp David 
Published: December 2018

AbstractEvolutionary debunking arguments aim to undercut the epistemological status of our evaluative beliefs on the basis of the genesis of our belief‐forming tendencies. This paper addresses the issue whether responses to these arguments must be question‐begging. It argues for a pragmatic understanding of question‐beggingness, according to which whether an argument is question‐begging depends on the argumentative context. After laying out the debunking argument, the paper considers a variety of responses. It asks whether metaethical responses, such as Sharon Street’s response that relies on a version of antirealism, can avoid begging the question. It argues that so‐called ‘third‐factor’ responses, which rely on substantive evaluative views, are not question‐begging in all contexts. Similarly, it argues, my own ‘quasi‐tracking’ response is not question‐begging in all contexts. Finally, the paper asks whether responses to the debunking argument can avoid begging the question against someone who is convinced at the outset that the argument is sound.
Debunking leftward progress
Authors: Huemer Michael 
Published: December 2018

AbstractIn earlier work, I argued that observed changes in moral values over human history are best explained as cognitive progress: societies tend over the long term to move closer to the objective moral truth. It is also true that, in recent decades, liberal democracies have moved strongly in the direction of greater government regulation and wealth redistribution. Does this mean that extensive regulation and redistribution are objectively good? I argue that the answer is no; these recent trends are importantly different from earlier examples of moral progress in ways that enable them to be satisfyingly explained without adverting to objective moral correctness.
Demarcating depression
Authors: Tully Ian 
Published: December 2018

AbstractHow to draw the line between depression‐as‐disorder and non‐pathological depressive symptoms continues to be a contested issue in psychiatry. Relatively few philosophers have waded into this debate, but the tools of philosophical analysis are quite relevant to it. In this paper, I defend a particular answer to this question, theContextualapproach. On this view, depression is a disorder if and only if it is a disproportionate response to a justifying cause or else is unconnected to any justifying cause. I present four objections to this approach and then defend it from them. Along the way, I explain why it matters whether we get this question right.
Luteal vascularity and embryo dynamics in mares during early gestation: Effect of age and endometrial degeneration
Authors: Camargo Ferreira Jair , Linhares Boakari Yatta , Sousa Rocha Noeme , Saules Ignácio Fernanda , Barbosa da Costa Guilherme , de Meira Cezinande 
Published: December 2018

ContentsThe present study characterized the luteal status and the dynamic of the conceptus during the first 20 days of gestation in mares with different ages and degrees of endometrial degeneration. Total area of the corpus luteum (CL), luteal vascularity, CL area with blood signals, progesterone concentrations (P4), embryonic vesicle diameter, number of embryonic location changes, embryonic fixation position and uterine contractility were evaluated. In Experiment 1, mares ≤6 years of age (Young group, 5.6 ± 0.2 years, n = 7 mares) and mares ≥15 years of age (Old group, 17.2 ± 0.9 years, n = 6 mares) were used to investigate the effect of age. In Experiment 2, the luteal and embryonic parameters were compared between mares with minimal (Mild group, endometrial category I, n = 9 mares) and severe (Severe group, endometrial category III, n = 7 mares) endometrial degeneration. The Old and Severe groups had greater (p ≤ 0.04) total CL area and reduced luteal vascularity (p ≤ 0.04) than the Young and Mild groups, respectively. However, P4 levels and CL area with blood signals were similar (p ≥ 0.8) between the groups. A negative effect of age (p < 0.01), but not of endometrial degeneration (p = 0.6), was found for the embryonic vesicle diameter. The conceptus mobility was high (p > 0.1) until day 14 of gestation in the Severe group, while a reduced number of changes of the embryo location was detected earlier (p < 0.05) in the Old group. In conclusion, the newly formed CL of aged mares and mares with severe endometrial degeneration suffered a structural remodelling to safeguard the local blood supply and the continuous P4 output during early gestation. Moreover, an earlier reduction of the embryonic mobility and a delayed development of the conceptus were associated with advanced age, regardless of the degree of endometrial degeneration.
Renewable Portfolio Standards and Policy Stringency: An Assessment of Implementation and Outcomes
Authors: Anguelov Nikolay , Dooley William F. 
Published: December 2018

AbstractThis research examines the impact of increasing the stringency of renewable portfolio standards (RPS) on the consumption of energy produced from renewable sources. Putting prior findings in the context of policy learning, first we focus on technological innovation, factor endowments, and economic energy dependence of American states to track how RPS have proliferated and strengthened. Next, we look at the net effect of this RPS evolution on state fossil fuel energy divestment. To evaluate the interplay between: a) the political desire to lower fossil fuel use, b) technological feasibility to do so, and c) the economic trade‐offs and risks, we focus on the industrial sector dependence on energy security and affordability. Our results indicate that energy security is a priority and even in light of increasing RPS stringency, states with relatively weak but mandatory RPS are leaders in aggregate renewable energy consumption. This fact is due to favoring biofuel and hydro generation rather than solar and wind because of lower deployment costs.
An oracle property of the Nadaraya–Watson kernel estimator for high‐dimensional nonparametric regression
Authors: Conn Daniel , Li Gang 
Published: December 2018

AbstractThe Nadaraya–Watson estimator is among the most studied nonparametric regression methods. A classical result is that its convergence rate depends on the number of covariates and deteriorates quickly as the dimension grows. This underscores the “curse of dimensionality” and has limited its use in high‐dimensional settings. In this paper, however, we show that the Nadaraya–Watson estimator has an oracle property such that when the true regression function is single‐ or multi‐index, it discovers the low‐rank dependence structure between the response and the covariates, mitigating the curse of dimensionality. Specifically, we prove that, using K‐fold cross‐validation and a positive‐semidefinite bandwidth matrix, the Nadaraya–Watson estimator has a convergence rate that depends on the number of indices rather than on the number of covariates. This result follows by allowing the bandwidths to diverge to infinity rather than restricting them all to converge to zero at certain rates, as in previous theoretical studies.
Development of physical fitness performance in young Swiss men from 2006 to 2015
Authors: Wyss Thomas , Roos Lilian , Studer Fabian , Mäder Urs , Beuchat Christiane , Staub Kaspar 
Published: December 2018

From 1980 to 2000, physical fitness decreased and body mass index (BMI) increased in the population of many industrialized countries. Little is known about these trends after the year 2000. This study aimed to investigate physical fitness performance, physical activity (PA) behavior, and BMI of young, male Swiss adults between 2006 and 2015. For this purpose, results from the Swiss Armed Forces mandatory recruitment were used. A total of 306 746 male conscripts provided complete fitness test data, mean ± SD (range from 5th to 95th percentile): 20 ± 1 (18‐21) years, 178 ± 7 (168‐189) cm; 74 ± 13 (58‐97) kg, predicted maximal oxygen consumption of 49.9 ± 4.6 (41.8‐56.9) mL/kg/min (Conconi test), 125 ± 58 (43‐232) seconds in trunk muscle strength test (prone bridge), 2.31 ± 0.24 (1.90‐2.66) m in standing long jump, 6.46 ± 0.73 (5.30‐7.70) m in seated shot put (2 kg medical‐ball shot) and 45.6 ± 12.2 (29.9‐66.7) seconds in one‐leg standing test (sum of both legs; eyes closed after 10 seconds and head tilted back after 20 seconds). In the investigated population, 73.8% fulfilled basic PA recommendations, 46.2% were classified as regularly vigorously active. Performances in aerobic endurance and muscle power did not show secular changes over time. However, core stability performance and PA behavior increased, while balance ability decreased over this 10‐year period. Average BMI increased by 2.0% between 2006 and 2010 and did not change thereafter. Male Swiss adults are at least as physically fit as they were a decade ago. The secular trends of decreasing physical performances and increasing BMI have stopped, and self‐reported sport participation and leisure time PA have been increased in the observed population over the last 10 years.
Effects of compaction on soil hydraulic properties, penetration resistance and water flow patterns at the soil profile scale
Authors: Mossadeghi‐Björklund Mona , Jarvis Nicholas , Larsbo Mats , Forkman Johannes , Keller Thomas 
Published: December 2018

AbstractThe aim of this study was to quantify the effects of compaction on water flow patterns at the soil profile scale. Control and trafficked plots were established in field trials at two sites. The trafficked treatment was created by four passes track‐by‐track with a three‐axle dumper with a maximum wheel load of 5.8 Mg. One year later, dye‐tracing experiments were performed and several soil mechanical, physical and hydraulic properties were measured to help explain the dye patterns. Penetration resistance was measured to 50 cm depth, with saturated hydraulic conductivity (Ks), bulk density, and macroporosity and mesoporosity being measured on undisturbed soil cores sampled from three depths (10, 30 and 50 cm). Significant effects of the traffic treatment on the structural pore space were found at 30 cm depth for large mesopores (0.3–0.06 mm diameter), but not small mesopores (0.06–0.03 mm) or macroporosity (pores > 0.3 mm). At one of the sites, ponding was observed during the dye‐tracing experiments, especially in the trafficked plots, because of the presence of a compacted layer at plough depth characterized by a larger bulk density and smaller structural porosity and Ks values. Ponding did not induce any preferential transport of the dye solution into the subsoil at this site. In contrast, despite the presence of a compacted layer at 25–30 cm depth, a better developed structural porosity in the subsoil was noted at the other site which allowed preferential flow to reach to at least 1 m depth in both treatments.
How Communication Can Make Voters Choose Less Well
Authors: Hahn Ulrike , von Sydow Momme , Merdes Christoph 
Published: December 2018

AbstractWith the advent of social media, the last decade has seen profound changes to the way people receive information. This has fueled a debate about the ways (if any) changes to the nature of our information networks might be affecting voters’ beliefs about the world, voting results, and, ultimately, democracy. At the same time, much discussion in the public arena in recent years has concerned the notion that ill‐informed voters have been voting against their own self‐interest. The research reported here brings these two strands together: simulations involving agent‐based models, interpreted through the formal framework of Condorcet's (1785) jury theorem, demonstrate how changes to information networks may make voter error more likely, even though individual competence has largely remained unchanged.
Aggregating resistant Staphylococcus aureus induces hypocoagulability, hyperfibrinolysis, phagocytosis, and neutrophil, monocyte, and lymphocyte binding in canine whole blood
Authors: Krogh Anne K. H. , Haaber Jakob , Bochsen Louise , Ingmer Hanne , Kristensen Annemarie T. 
Published: December 2018

BackgroundStaphylococcus aureus is an opportunistic pathogen with the ability to form mobile planktonic aggregates during growth, in vitro. The in vivo pathophysiologic effects of S aureus aggregates on host responses are unknown. Knowledge of these could aid in combating infections.ObjectiveThis study aimed to investigate the effect of increasing concentrations of two different aggregating S aureus strains on the hemostatic and inflammatory host responses in canine whole blood. The hypothesis was that aggregating bacteria would induce pronounced hemostatic and inflammatory responses.MethodsCitrate‐stabilized whole blood from 10 healthy dogs was incubated with two strains of aggregating S aureus at three different concentrations. Each sample was analyzed using tissue factor‐thromboelastography (TF‐TEG) and the formed clot was investigated with electron microscopy. The plasma activated partial thromboplastin time (aPTT), prothrombin time (PT), fibrinogen, and D‐dimer tests were measured. Bacteria‐leukocyte binding was evaluated with flow cytometry, and neutrophil phagocytosis was assessed using light and transmission electron microscopy.ResultsThe highest concentration of bacteria resulted in a significantly shortened TF‐TEG initiation time, decreased alpha, maximum amplitude, global strength, and increased lysis. In addition, significantly shortened PT, decreased fibrinogen, and increased D‐dimers were demonstrated at the highest concentration of bacteria. Lower concentrations of bacteria showed no differences in TF‐TEG when compared with controls. The findings were similar for both S aureus strains. Increased concentration‐dependent binding of bacteria and leukocytes and neutrophil bacterial phagocytosis was observed.ConclusionsTwo strains of S aureus induced alterations of clot formation in concentrations where bacterial aggregates were formed. A concentration‐dependent cellular inflammatory response was observed.
Sentinel lymph node mapping of the canine anal sac using lymphoscintigraphy: A pilot study
Authors: Linden Daniel S. , Cole Robert , Tillson D. Michael , Boothe Harry W. , Matz Brad M. 
Published: December 2018

AbstractSentinel lymph node mapping and biopsy are important parts of oncologic staging in human medicine. Sentinel lymph node mapping enables identification of the first lymph node to receive lymphatic drainage while avoiding unnecessary lymph node dissection. Anal sac adenocarcinoma is the most common malignant neoplasm of the canine perineal area. For dogs with anal sac adenocarcinoma, lympadenectomy and metastasis to the iliosacral lymphocentrum are negative prognostics indicators. The objectives of this prospective, two by two, crossover pilot study were to establish the feasibility of lymphoscintigraphy using Technetium‐99 sulfur colloid of the canine anal sac of healthy dogs, compare two injection techniques, and the time for identification of sentinel lymph nodes using each technique. We hypothesized that both intramural and perimural injections of the canine anal sac would identify similar sentinel lymph node drainage. The sentinel lymph node was identified in all dogs using either technique. Intramural injection of the canine anal sac showed radiopharmaceutical uptake faster than perimural injection technique (P = 0.040). There was concordance between intramual and perimural techniques for the sentinel lymph node identified in 50% of cases. A sacral lymph node was identified as sentinel in three of eight dogs (37.5%). Lymphoscintigraphy of the canine anal sac is safe and feasible in normal dogs; however, the method of injection technique seems to have a significant effect on the sentinel lymph node identified.
Numerical simulation of baffle effect on the performance of sedimentation basin
Authors: Saeedi E. , Behnamtalab E. , Salehi Neyshabouri S. A. A. 
Published: December 2018

AbstractSedimentation basin is an important component of every water treatment process. In order to improve the sedimentation efficiency (SE) of rectangular sedimentation basins, many researchers have proposed various methods. Among the suggested methods, the change of the geometry with installation of baffle in the basin floor is simple and completely economic. In this research, the hydraulic characteristics of the flow with various baffle configurations in the basin floor have been evaluated and the best geometry of the baffle has been presented. The agreement between numerical and experimental results was good. The results showed that the flow in the sedimentation basin is strongly influenced by the baffle. Also, the baffles installed with lower height and closer to the basin inlet and baffles with high height and far from the basin inlet have the greatest effect on the SE.
Discordance between histologic and visual assessment of tissue viability in excised burn wound tissue
Authors: Karim Aos S. , Yan Amy , Ocotl Edgar , Bennett Daniel D. , Wang Ziyue , Kendziorski Christina , Gibson Angela L.F. 
Published: December 2018

ABSTRACTThe regenerative capacity of burn wounds, and the need for surgical intervention, depends on wound depth. Clinical visual assessment is considered the gold standard for burn depth assessment but it remains a subjective and inaccurate method for tissue evaluation. The purpose of this study was to compare visual assessment with microscopic and molecular techniques for human burn depth determination, and illustrate differences in the evaluation of tissue for potential regenerative capacity. Using intraoperative visual assessment, patients were identified as having deep partial thickness or full thickness burn wounds. Tangential excisions of burn tissue were processed with hematoxylin and eosin to visualize tissue morphology, lactate dehydrogenase assay to ascertain cellular viability, and Keratin‐15 and Ki67 to identify epidermal progenitor cells and proliferative capacity, respectively. RNA from deep partial and full thickness burn tissue as well as normal tissue controls were submitted for RNA sequencing. Lactate dehydrogenase, Keratin‐15, and Ki67 were found throughout the excised burn wound tissue in both deep partial thickness burn tissues and in the second tangential excision of full thickness burn tissues. RNA sequencing demonstrated regenerative capacity in both deep partial and full thickness burn tissue, however a greater capacity for regeneration was present in deep partial thickness compared with full thickness burn tissues. In this study, we highlight the discordance that exists between the intraoperative clinical identification of burn injury depth, and microscopic and molecular determination of viability and regenerative capacity. Current methods utilizing visual assessment for depth of injury are imprecise, and can lead to removal of viable tissue. Additionally, hematoxylin and eosin microscopic analysis should not be used as the sole method in research or clinical determination of depth, as there are no differences in staining between viable and nonviable tissue.
Bianchi type III cosmological model with hybrid scale factor in the presence of Van der Waals fluid in Lyra manifold
Authors: Singh Kangujam Priyokumar , Mollah Mahbubur Rahman 
Published: December 2018

The search for the existence of Lyra manifold in a hybrid universe interacting with Van der Waals fluid using Bianchi type III metric is presented in this paper. To find the exact cosmological solutions, we use certain physical relations between the metric potentials and the average scale factor is assumed to be [Formula: see text] (see Ref. 1) describing the hybrid character of scale factor with the generation of a model of transitioning phase from early decelerating to the present accelerating universe. In this model, when we investigate further about the role of the Van der Waals fluid with Lyra geometry, interestingly, we found that this universe behaves as one containing with dark energy and at the late stage a part of the dark energy behaves as phantom type. This part being generated by the Lyra manifold itself may be taken as a source of dark energy. Some physical as well as geometrical aspects of the model universe are also presented.