bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural Low‐Melting Mixture Solvents for Green Recovery of Spent All‐Solid‐State Sodium‐Ion Batteries with Superior Efficiency over Lithium‐Ion Batteries
Authors: Chen Yu , Shen Yaxue , Liu Zicheng , Yang Mingshuai , Zhang Yuqing , Niu Zihang , Wang Yanlong , Feng Minghui , Shi Zhuojia 
Published: December 2024

AbstractSpent all‐solid‐state sodium‐ion batteries (ASIBs) containing toxic and precious metal would be produced significantly and lead to resource waste and environmental pollution as the wide application of ASIBs in the near future. Therefore, it is necessary to develop green strategy for recovery of ASIBs. Here, we propose a safe, mild and green strategy to recover toxic and precious metals from cathode/solid electrolyte of ASIBs by using natural low‐melting mixture solvents (LoMMSs) with high selectivity and high leaching efficiency. Natural LoMMSs are abundant, natural available, cheap, non‐flammable, biodegradable and biocompatible. Results show that natural LoMMSs could leach nearly 100 % Na and achieve superhigh Na/Zr selectivity of up to 58 from ASIBs at mild temperature, outperforming the recycling efficiency and selectivity of lithium‐ion batteries cathode. More importantly, we find that water could be used as a green and low‐cost anti‐solvent to precipitate the extracted metal from the leachate with low‐energy consumption at room temperature. This work provides a cost‐effective, energy‐saving, mild, green strategy for the recovery of cathode/solid electrolyte from spent ASIBs with high safety and high selectivity.
The conceptual potential of ‘more‐than‐human care’: A reflection with an artisanal fishing village in Brazil
Authors: Ressiore C. Adriana , Ludwig David , El‐Hani Charbel 
Published: December 2024

AbstractAs dominant approaches to biodiversity loss and climate change continue to fail in mitigating current socio‐environmental crises, scholars and activists are exploring novel conceptual frameworks to drive transformative change in conservation. Among these, more‐than‐human care has emerged as a concept at the intersection of feminist debates about care and post‐humanist discussions around the more‐than‐human. Although more‐than‐human care is increasingly referenced in the literature, it remains sparsely situated in the Global South. This article investigates the concept's potential to articulate care relations that can foster more plural, respectful, and transformative biodiversity conservation practices in local communities. Our research is situated in an artisanal fishing village in Brazil, where we engaged with both human and non‐human members of the community to engage with their perspectives on more‐than‐human care and its relevance to their local concerns. From our analysis, four key dimensions emerged: the vital and everyday nature of caring; the relationality between humans and non‐humans; reciprocity; and the fostering of flourishing for as many as possible. Our core argument is that the interaction between community practices and care theory enables new perspectives that center on daily and reciprocal care relations often overlooked in mainstream conservation approaches. By situating the conceptual potential of more‐than‐human care within the Global South, we underscore its ability to make the invisible visible and to inspire action for transformative change.
An investigation into the applicability of rapid artificial intelligence‐assisted compressed sensing in brain magnetic resonance imaging performed at 5 Tesla field strength
Authors: Zhou Liqiang , Wang Jiaqi 
Published: December 2024

AbstractBackgroundBrain magnetic resonance imaging (MRI) at 5 T offers unprecedented spatial resolution but is often limited by long scan times. Acceleration techniques, such as compressed sensing (CS) and artificial intelligence‐assisted compressed sensing (ACS), have the potential to speed up the acquisition process while maintaining image quality. This study aims to evaluate and compare the performance of CS and ACS (with various acceleration factors) in brain MRI imaging at 5 T.MethodsIn this study, we enrolled 12 healthy volunteers and compared ACS‐accelerated 5 T brain MRI with conventional methods of CS. The ACS acceleration factors for the brain protocol, consisting of 3D T1‐weighted sequences and 2D T2‐weighted sequences, were optimized in a pilot study on healthy volunteers (acceleration factor, 2.06–3.41× in T2‐weighted imaging and 3.52–8.49× in T1‐weighted imaging). We evaluated the images acquired from patients using various acceleration methods on the basis of acquisition times, the signal‐to‐noise ratio (SNR), the contrast‐to‐noise ratio, subjective image quality, and diagnostic agreement.ResultsOur findings revealed that ACS acceleration significantly reduced the acquisition times for T1‐ and T2‐weighted sequences by up to 43% and 53%, respectively, compared with traditional CS at 5 T. Importantly, this acceleration was achieved while maintaining excellent image quality, demonstrated by higher or comparable SNR and contrast‐to‐noise ratio values.ConclusionsThe optimal ACS acceleration factors for 5 T brain MRI were determined to be 2.73× for 2D T2‐weighted sequences and 6.5× for 3D T1‐weighted sequences. ACS not only facilitates rapid imaging but also ensures comparable image quality and diagnostic performance, highlighting its potential to revolutionize high‐field MRI scanning.
Vitamin D3 Exerts a Neuroprotective Effect in Metabolic Syndrome Rats: Role of BDNF/TRKB/Akt/GS3Kβ Pathway
Authors: Aladdin Noha , Ghareib Salah A. 
Published: December 2024

ABSTRACTMetabolic syndrome (MetS) is usually associated with cognitive impairment, neuropathic pain, and reduced brain‐derived neurotrophic factor (BDNF) levels. BDNF via tropomyosin receptor kinase B (TrkB) exerts neuroprotection by activating protein kinase B (Akt) to inhibit glycogen synthase kinase‐3β (GSK3β). Although Vitamin D3 (VitD3) has demonstrated favorable metabolic and neuronal outcomes in MetS, the precise molecular mechanisms underlying its neuroprotective effects remain poorly elucidated. We aimed to test the hypothesis that VitD3 mitigates MetS‐induced cognition deficits and neuropathic pain via modulating the BDNF/TRKB/Akt/GS3Kβ signaling pathway. MetS was induced in male rats by 10% fructose‐supplemented water and 3% salt‐enriched diet. After 6 weeks, normal and MetS rats received either vehicle or VitD3 (10 µg/kg/day) for an additional 6 weeks. Glycemic status, lipid profile, and behavioral changes were assessed. The advanced glycation end products (AGEs), and markers of inflammation (TNF‐α and NF‐κB), oxidative stress (malondialdehyde), and apoptosis (caspase3), as well as BDNF, TrkB, PI3K, Akt, GSK3β, phosphorylated tau, and amyloid beta (Aβ) were assessed in the cerebral cortex. MetS rats had deteriorated glycemic and lipid profiles, higher AGEs, reduced levels of BDNF, TrkB, PI3K, and active Akt, along with increased GSK3β levels, inflammation, oxidative stress, and apoptosis. These changes were associated with higher levels of cognitive impairment markers phosphorylated tau and Aβ, as well as behavioral changes indicative of cognitive impairment and neuropathic pain. VitD3 improved the cognitive and behavioral alterations, while mitigating the associated molecular derangements. Our results indicate that VitD3 may exert neuroprotective effects by modulating the BDNF/TrkB/PI3K/Akt/GSK3β signaling pathway.
ESG Ratings and CEO Charitable Stock Donations: Is Firm ESG Aligned With CEO Personal Philanthropy?
Authors: Dai Han , Lee Daeun , Liang Ying , Litt Barri 
Published: December 2024

ABSTRACTIn the evolving landscape of sustainable investing, with unprecedented market attention on environmental, social, and governance (ESG) information, our study delves into the relationship between a firm's ESG ratings and the philanthropic behavior of its chief executive officer (CEO), particularly in terms of charitable stock donations. Examining US firms and utilizing comprehensive ESG data from Refinitiv, we find that ESG‐rated firm CEOs engage in greater personal stock donation activity as compared to their non‐ESG counterparts. They also appear to time donations in a less self‐serving manner. When we isolate ESG firms, we find CEOs of the strongest ESG performers exhibit no self‐interested timing behavior. Our study contributes to the sparse literature on CEO charitable behavior, shedding light on the potential alignment between ESG performance at the firm level and genuine, altruistic giving at the CEO level. Such alignment provides valuable insight for investors, policymakers, nonprofit organizations, and researchers interested in the intersection of sustainable investing and executive action.
Eating Disorders, Co‐Morbid Disorders and Early Risk Factors Amongst Post‐9/11 Veteran Men and Women
Authors: Cooper Zafra , Smith Brian N. , Kehle‐Forbes Shannon , Dorset Julianne , Mitchell Karen S. 
Published: December 2024

ABSTRACTObjectiveTo assess, by interview, the rates of eating disorders in a nationally representative sample of recent veterans, describe their DSM‐5 eating disorder diagnoses and the occurrence of comorbid psychiatric disorders. To conduct an exploratory case‐control analysis of previously documented and additional specific military risk factors before eating disorder onset to inform studies of prospective risk.MethodUsing a two‐stage design, probable cases and controls were identified by screening questionnaires from a sample of 1494 veterans who completed a survey study and interviewed to establish case status and confirm probable co‐morbid psychiatric diagnoses. Previously documented risk factors and military risk factors occurring before disorder onset were investigated.ResultsNinety‐one cases and 51 controls were confirmed. Weighted prevalence for any eating disorder was 5.2%, with estimates for anorexia nervosa, bulimia nervosa, binge eating disorder and other specified eating disorder being 0.01%, 0.6%, 1.4%, and 1.6%, respectively. Seventy‐nine (86.8%) confirmed cases had a diagnosis of one or more co‐morbid psychiatric disorders. Previously documented risk factors were associated with subsequent case status, while in this sample, military risk factors were not.DiscussionRates of eating disorder and co‐occurring psychiatric disorders in recent veterans were comparable to those reported for non‐veterans, with levels of posttraumatic stress disorder likely higher. As co‐occurring psychiatric disorders, particularly posttraumatic stress disorder, may complicate achieving good outcomes with existing evidence‐based treatments, there is an urgent need to adapt them where necessary to improve outcomes. Military risk factors may maintain or exacerbate pre‐existing problems and need to be investigated alongside other maintaining factors in longitudinal studies.Public SignificanceRates of eating disorder and co‐occurring psychiatric disorders in recent veterans were comparable to those reported for non‐veterans, highlighting a need to detect eating problems and address unmet treatment need. Co‐occurring psychiatric disorders may complicate achieving good outcomes with existing treatments, emphasising a need to adapt them to improve outcomes. Investigating maintaining factors, including military factors in longitudinal studies will likely aid treatment development.
Long‐term changes in riparian connectivity and groundwater chemistry in an urban watershed
Authors: Washington Brittany N. , Groffman Peter M. , Duncan Jonathan M. , Band Lawrence E. , Miller Andrew J. 
Published: December 2024

AbstractHydrologic alterations associated with urbanization can weaken connections between riparian zones, streams, and uplands, leading to negative effects on the ability of riparian zones to intercept pollutants carried by surface water runoff and groundwater flow such as nitrate (NO3−) and phosphate (PO43−). We analyzed the monthly water table as an indicator of riparian connectivity, along with groundwater NO3− and PO43− concentrations, at four riparian sites within and near the Gwynns Falls Watershed in Baltimore, MD, from 1998 to 2018. The sites included one forested reference site (Oregon Ridge), two suburban riparian sites (Glyndon and Gwynnbrook), and one urban riparian site (Cahill) with at least two locations and four monitoring wells, located 5 m from the center of the stream, at each site. Results show an increase in connectivity as indicated by shallower water tables at two of the four sites studied: Glyndon and Cahill. This change in connectivity was associated with decreases in NO3− at Glyndon and increases in PO43− at Glyndon, Gwynnbrook, and Cahill. These changes are consistent with previous studies showing that shallower water table depths increase anaerobic conditions, which increase NO3− consumption by denitrification and decrease PO43− retention. The absence of change in the forested reference site, where climate would be expected to be the key driver, suggests that other drivers, including best management practices and stream restoration projects, could be affecting riparian water tables at the two suburban sites and the one urban site. Further research into the mechanisms behind these changes and site‐specific dynamics is needed.
Fertilizer management approaches influence nutrient leaching from residential landscapes
Authors: Reisinger Alexander J. , Bean Eban Z. , Clark Mark , Levine Ansley J. , Wilson P. Christopher 
Published: December 2024

AbstractResidential lawn management often includes fertilizer application to encourage healthy plant growth and support the aesthetic preferences of homeowners and communities. These inputs may negatively impact the environment by increasing nutrient export to aquatic ecosystems via surface runoff or leaching through soil into groundwater. Fertilizer management and nutrient export are of particular concern in karst areas like North‐Central Florida, where the underlying karst geology leads to rapid, direct connections between surface and groundwater ecosystems. We quantified nitrogen (N) and phosphorus (P) leaching from residential landscapes in North‐Central Florida. We investigated nutrient leaching from landscapes spanning a real estate gradient and across different fertility treatments (no N fertilizer, synthetic mineral fertilizer, biosolids‐based organic mineral fertilizer, compost topdressing, natural areas). We measured leachate from these landscapes weekly for 1 year. All residential landscapes, including control yards that received no N fertilizer, leached >10x more nitrate than natural areas, and landscapes treated with synthetic fertilizer exhibited an >80x increase in nitrate leaching. Fertilizer treatments also appeared to alter the N leaching composition, with a greater proportion of total dissolved N leaching coming from nitrate in fertilized treatments (synthetic and organic) compared to natural, control, or compost‐treated landscapes. These results show that landscape management and human actions are important drivers of nutrient leaching in residential landscapes. While all residential lawns leached more N than natural areas, less leaching was associated with certain management approaches. When implemented at larger scales, these approaches may reduce the likelihood of negative impacts of residential landscapes on regional water quality.
A case of cutaneous small vessel vasculitis after the seventh dose of COVID‐19 vaccination
Authors: Sato Hiroshi , Maruyama Riruke , Kishi Hirofumi , Higashi Koichiro , Yuki Mika , Nagami Haruhiko , Tabara Hideki 
Published: December 2024

AbstractA 77‐year‐old woman on regular hemodialysis was admitted due to purpura on her extremities, elevated C‐reactive protein (CRP), D‐dimer, and syncope attack. Despite hospitalization and treatment, her purpura got worse, and a skin biopsy revealed cutaneous small vessel vasculitis (CSVV). No apparent cause could be pointed out for CSVV. Her purpura had deteriorated until we started treatment with prednisolone (PSL). We later confirmed that she had received her seventh COVID‐19 vaccination before the onset of purpura on her extremities. In this case, the highlight is that even the seventh dose of the COVID‐19 vaccination could potentially induce CSVV.
YAP1 Overexpression Enhances the Aerobic Glycolysis Process via Suppression of EGLN2 in Pancreatic Ductal Adenocarcinoma
Authors: Hu Pengfei , Dou Ruohan , Qi Zihao , Liu Guanya , Su Yuantao 
Published: December 2024

ABSTRACTBackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive diseases and has remarkably high mortality rates. In recent years, altered metabolism has been shown to contribute to the maintenance of pancreatic cancer malignancies. However, the molecular mechanism underlying glucose metabolism reprogramming remains elusive. The aim of this study was to elucidate the role of Yes‐associated protein (YAP1), an important effector of the Hippo pathway, in the regulation of aerobic glycolysis in pancreatic cancer. Moreover, the contributions of YAP1 and its associated glycolytic enzymes to prognosis were assessed via The Cancer Genome Atlas (TCGA) dataset.MethodsYAP1 expression was silenced by short hairpin RNA (shRNA), and its effects on glycolytic activity and mitochondrial respiration were analysed via Agilent Seahorse XF Analysers. The effects of YAP1 on hypoxia‐inducible factor‐1α (HIF‐1α) and its transcriptional activity on glycolytic genes were examined via shRNA‐mediated silencing of YAP1. The underlying mechanism by which YAP1 controls the HIF‐1α protein level was analysed by exploring the interaction between YAP1 and egg‐laying‐defective nine family (EGLN) members, which are well‐established regulators of the HIF‐1α protein level. Finally, the effects of YAP1, EGLN and glycolytic genes on prognosis were analysed via TCGA dataset.ResultsWe found that silencing YAP1 expression inhibited anabolic glycolysis in pancreatic cancer cells. YAP1 was demonstrated to regulate the HIF‐1α protein level, transcriptional activity and the expression of HIF‐1α‐targeted glycolytic genes. In‐depth analysis demonstrated that EGLN2, a modulator of the HIF‐1α protein level, was a direct target of YAP1. Low EGLN2 expression was associated with a poor prognosis. By analysing TCGA dataset and performing immunohistochemical staining, we demonstrated that YAP1 expression was negatively correlated with EGLN2 expression at the mRNA level and protein levels.ConclusionsThe present study demonstrated that YAP1 positively regulates aerobic glycolysis by inhibiting EGLN2 expression, which results in an increased HIF‐1α protein level and transcriptional activity. YAP1 was positively regulated and significantly correlated with HIF‐1α‐targeted glycolytic genes, including glucose transporter type 1(GLUT1), hexokinase2 (HK2) and lactate dehydrogenase A (LDHA). Elevated YAP1 expression and concomitant downregulation of EGLN2 contributed to poor survival in patients with pancreatic cancer. Our results suggest that YAP1 may be a promising predictive marker and treatment target for human pancreatic cancer.
Vitamin and trace element status and growth in children with short bowel syndrome being weaned off parenteral nutrition
Authors: Tuokkola Jetta , Olkkonen Elina , Gunnar Riikka , Pakarinen Mikko , Merras‐Salmio Laura 
Published: December 2024

AbstractObjectivesChildren with short bowel syndrome (SBS) are at increased risk of micronutrient deficiencies. We aimed to study weaning off parenteral nutrition (PN) as a risk factor for vitamin and trace element deficiencies and growth deficit.MethodsChildren born between 2010 and 2019, treated for SBS in Helsinki University Hospital, were followed for their nutrition, growth, and vitamin and trace element biochemical status. Information on these as well as patient characteristics and intestinal anatomy were collected from electronic patient records.ResultsA total of 59 patients with SBS were identified. The weaning period was found to be a risk factor for micronutrient deficiencies and growth. Most frequent deficiencies were detected for vitamin K as suggested by prothrombin time (PT) (91% of patients), vitamin D (70%), and vitamin A (67%). Other deficiencies were less common with 44% for vitamin B12, 25% for selenium, 19% for copper, 24% for zinc, and 11% for vitamin E. For all the studied micronutrients, 3 months before to 1 month postweaning had the highest rate of micronutrient deficiencies, except for vitamin B12, for which the highest proportion of deficiencies presented at 1–6 months postweaning.ConclusionsThe weaning period from PN is a risk for micronutrient deficiencies. Regular monitoring and sufficient supplementation are essential for preventing malnutrition.
Optimizing transport methods to preserve function of self‐innervating muscle cells for laryngeal injection
Authors: Kaefer Samuel L. , Zhang Lujuan , Brookes Sarah , Morrison Rachel A. , Voytik‐Harbin Sherry , Halum Stacey 
Published: December 2024

AbstractObjectivesRecently, our laboratory has discovered a self‐innervating population of muscle cells, called motor endplate‐expressing cells (MEEs). The cells innately release a wide variety of neurotrophic factors into the microenvironment promoting innervation when used as an injectable treatment. Unlike other stem cells, the therapeutic potential of MEEs is dependent on the cells' ability to maintain phenotypical cell surface proteins in particular motor endplates (MEPs). The goal of this study is to identify transport conditions that preserve MEE viability and self‐innervating function.MethodsMuscle progenitor cells (MPCs) of adult Yucatan pigs were cultured and induced to generate MEEs. Effects of short‐term cryopreservation methods were studied on MPC and MEE stages. A minimally supplemented medium was investigated for suspension‐mediated transport, and MEEs were loaded at a constant concentration (1 × 107 cells/mL) into plastic syringes. Samples were subjected to varying temperatures (4, 22, and 37°C) and durations (6, 18, 24, and 48 h), which was followed by statistical analysis of viability. Transport conditions maintaining viability acceptable for cellular therapy were examined for apoptosis rates and expression of desired myogenic, neurotrophic, neuromuscular junction, and angiogenic genes.ResultsCryopreservation proved detrimental to our cell population. However, a minimally supplemented medium, theoretically safe for injection, was identified. Transport temperature and duration impacted cell viability, with warmer temperatures leading to faster death rates prior to the end of the study. Transport conditions did not appear to affect apoptotic rate. Any expression change of desirable genes fell within the acceptable range.ConclusionsTransport state, medium, duration, and temperature must be considered during the transport of injectable muscle cells as they can affect cell viability and expression of integral genes. These described factors are integral in the planning of general cell transport and may prove equally important when the cell population utilized for laryngeal injection is derived from a patient's own initial muscle biopsy.