bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-dimensional Feature Tracking Cardiac Magnetic Resonance in Hypertrophic Cardiomyopathy: Comparison with Two-Dimensional Algorithm
Authors: Tomoaia Raluca , Lwin May , Soo Chin Yit , Anderton Thomas , Kamani Christel , Javed Wasim , Wahab Ali , Plein Sven 
Published: December 2024

Abstract

Aim
The aims of this study were to: 1) determine whether 2D and 3D feature tracking cardiac magnetic resonance (FT-CMR) are equivalent in patients with hypertrophic cardiomyopathy (HCM), 2) compare 3D FT-CMR values in HCM and healthy volunteers and 3) compare FT-CMR in most frequent HCM phenotypes.

Methods
Consecutive patients with HCM and LVEF>55% were included in the study. FT-CMR parameters included left ventricular (LV) global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain, which were calculated using both 2D and 3D FT-CMR derived from multi-slice 2D cine image stacks in the LV short and long axis plane. FT was calculated using Circle Cvi42 software.

Results
Sixty HCM patients (66.7% male, mean age 58.2 ± 15.8 years) were included (56.7% septal HCM, 25% apical HCM). FT analysis was feasible in all individuals. Seventy-two percent of patients exhibited focal fibrosis in 2 [0-4] segments. As previously reported for healthy individuals, myocardial strain evaluated using 3D FT-CMR was consistently lower compared to 2D FT-CMR. The highest level of agreement was noted between the 2D and 3D values of GCS, with a mean difference of -0.3% (95% CI -1.81 to 1.2, p=0.68), while GRS showed the lowest agreement. In patients with apical HCM GLS 3D was significantly more reduced than in patients with septal HCM (-7.4% ± 4.1 vs. -10.5% ± 2.9, p=0.004).

Conclusions
3D FT-CMR is feasible in HCM patients. 3D FT is advantageous as it does not require additional scanning time, making it suitable for HCM patients with limited acoustic window and abnormal geometry.
ОСОБЕННОСТИ ОБНАРУЖЕНИЯ ТРИАЛКИЛФОСФИТОВ В СОСТАВЕ РЕАКЦИОННЫХ СМЕСЕЙ И ИХ ХРОМАТОМАСС-СПЕКТРОМЕТРИЧЕСКАЯ ХАРАКТЕРИСТИКА
Authors: Зенкевич Игорь Георгиевич , Носова Влада Эдуардовна 
Published: December 2024

Взаимодействие алифатических спиртов ROH с трихлоридом фосфора в отсутствие оснований приводит к образованию исключительно диалкилфосфонатов (RO)2PHO. Для получения недостаточно подробно охарактеризованных до настоящего времени триалкилфосфитов (RO)3Р, рН реакционных смесей регулировали добавками N,N-диметиланилина (рКа 5.1 ± 0.1). Идентификация триалкилфосфитов непосредственно в реакционных смесях без препаративного выделения предполагает совместное рассмотрение их масс-спектров и газохроматографических индексов удерживания при условии определения всех остальных компонентов таких смесей. Необходимость соблюдения этого условия привела к идентификации нескольких гомологов ранее не охарактеризованного ряда 2-алкокси-1,3,2-диоксафосфоланов, образующихся из случайной примеси этиленгликоля. Использование таких объединенных хроматомасс-спектрометрических параметров как гомологические инкременты индексов удерживания позволяет отличать триалкилфосфиты от изобарных диалкилфосфонатов [соединения обоих рядов относятся к гомологической группе у = 12, y º M(mod14)]. Несмотря на отсутствие в масс-спектрах с ионизацией электронами (ИЭ) сигналов молекулярных ионов, возможна оценка молекулярных масс триалкилфосфитов. Кроме того, сопоставление гомологических инкрементов индексов удерживания показывает, что по сравнению с диалкилфосфонатами триалкилфосфиты значительно менее полярны.
The interaction of aliphatic alcohols ROH with phosphorous trichloride at the absence of bases leads to the exclusive formation of dialkyl phosphonates (RO)2PHO. The same reaction can be used for synthesis of trialkyl phosphites (RO)3Р with controlling the pH of reaction mixtures by adding of N,N-dimethyl aniline (рКа 5.1 ± 0.1). The identification of trialkyl phosphites directly in mixtures without preliminary isolation is possible, but it implies the joint considering their mass spectra and gas chromatographic retention indices at the condition of identification of all constituents of these mixtures. The necessity for compliance with this condition has led to the identification of few homologues of previously not-characterized series of 2-alkoxy-1,3,2-dioxaphospholanes, which formed from the ethylene glycol as random impurity in N,N-dimethyl aniline. Using such joint GC/MS analytical parameters as homologous increments of retention indices allows distinguishing trialkyl phosphites from isobaric dialkyl phosphonates [both series belong to the same homologous group у = 12, y º M(mod14)]. The absence of the signals of molecular ions in EI mass spectra of trialkyl phosphites does not preclude the evaluation of their molecular weights. Besides that, the comparison of homologous increments explains the less polarity of trialkyl phosphites comparing with dialkyl phosphonates.
Определение фалькаринола методом высокоэффективной жидкостной хроматографии с тандемным масс-спектрометрическим детектированием
Authors: Жестовская Е.С. , Антохин А.М. , Таранченко В.Ф. , Василевский С.В. , Аксенов А.В. , Ставрианиди А.Н. , Родин И.А. , Шпигун О.А. 
Published: December 2024

В работе представлены результаты массспектрометрического исследования поведения фалькаринола в условиях ионизации электрораспылением и химической ионизации при атмосферном давлении в режиме регистрации положительных ионов. Разработан способ определения фалькаринола в лекарственном растительном сырье и препаратах на его основе с использованием метода высокоэффективной жидкостной хроматографии в сочетании с тандемной массспектрометрией высокого разрешения. Проведена апробация предложенного подхода при анализе коммерчески доступных образцов сухого растительного сырья и готовых экстрактов из корней растений семейства Аралиевых (Araliaceae). Диапазон линейности градуировочной зависимости стандартных растворов составил 0.0550мкгмл1, предел обнаружения 0.01мкгмл1.
Peculiar properties of highenergy dissociation mass spectra of falcarinol recorded by using atmospheric pressure chemical ionization and electrospray ionization (positive mode) were studied Technique of falcarinol determination in medicinal plant materials and preparations based on it was developed using highperformance liquid chromatography high resolution tandem mass spectrometry. The proposed method has been successfully tested on commercially available samples of dry plant materials and prepared extracts from the roots of plants of the Araliaceae family (Araliaceae). It was found that calibration curve was linear in the concentration range between 0.05 g mL1 and 50 g mL1, limits of detection was 0.01 g mL1.
Исследование метаболизма нового синтетического каннабиноида MMB-022 в моделях in vivo и in vitro методом жидкостной хроматомасс-спектрометрии
Authors: А.М. Григорьев , Н.А. Крупина , Е.В. Никитин , С.Е. Грибкова , В.А. Калашников 
Published: December 2024

В конце 2019 года на рынке психоактивных средств в Российской Федерации зафиксировано появление синтетического соединения, идентифицированного как метил 3-метил-2-(1-(пент-4-енил)-1H-индол-3-карбоксамидо)бутаноат и получившего краткое название MMB-022. Новое соединение обладает значительным структурным подобием с многими членами семейства синтетических каннабиноидов и, следовательно, может формировать соответствующие психоактивные эффекты. Редкой структурной особенностью MMB-022 является наличие двойной связи на конце N-алкилиндольной цепи. Учитывая интенсивный метаболизм синтетических каннабиноидов, выбор биомаркеров употребления MMB-022 ограничен его метаболитами. В условиях отсутствия информации о метаболизме нового соединения для человека, в данной работе представлены результаты структурной идентификации метаболитов, полученных в модельных экспериментах при экспонировании крыс и при ферментации MMB-022 на печеночных микросомах человека. Предполагаемые структуры выявленных метаболитов определяли методом жидкостной хроматографии с двумя масс-спектрометрами (квадруполь-времяпролетный и ионной ловушкой). В моче крыс найдены продукты гидролиза, гидроксилирования, карбоксилирования, образования дигидродиола на N-пентенильном остатке и N-депентелирования. Большинство метаболитов подтверждены in vitro. Полученные хроматомасс-спектрометрические характеристики метаболитов MMB-022 могут использоваться при рутинном анализе человеческой мочи.
At the end of 2019, the appearance of a synthetic compound identified as methyl 3-methyl-2-(1-(pent-4-enyl)-1H-indole-3-carboxamido)butanoate (briefly named MMB-022) was observed on the market of psychoactive drugs in the Russian Federation. The new compound has significant structural similarity to many members of the synthetic cannabinoid family and, therefore, can form corresponding psychoactive effects. A rare structural feature of MMB-022 is the presence of a double bond at the end of the N-alkylindole chain. Taking into account the intensive metabolism of synthetic cannabinoids, the choice of MMB-022 biomarkers is limited by its metabolites. In the absence of information on the metabolism of the MMB-022 in humans, this paper presents the results of structural identification of metabolites obtained in model experiments during rat exposure and fermentation of MMB-022 with human liver microsomes. The metabolites were tentatively identified by liquid chromatography with two mass spectrometers such as quadrupole-time-of-flight and ion trap. The products of hydrolysis, hydroxylation, carboxylation, formation of dihydrodiol on the N-pentenyl moiety and N-depentenylation were found in the rat urine. Most of the metabolites have been confirmed in vitro. The obtained chromatography/mass spectrometry features of MMB-022 metabolites can be used for routine analysis of human urine.
ОПРЕДЕЛЕНИЕ ПРОДУКТОВ КОНВЕРСИИ ФОСФОРОРГАНИЧЕСКИХ ОТРАВЛЯЮЩИХ ВЕЩЕСТВ В СТРОИТЕЛЬНЫХ МАТЕРИАЛАХ МЕТОДОМ ВЫСОКОЭФФЕКТИВНОЙ ЖИДКОСТНОЙ ХРОМАТОГРАФИИ С ТАНДЕМНЫМ МАСС-СЕЛЕКТИВНЫМ ДЕТЕКТИРОВАНИЕМ
Authors: М.А. Ленинский , Е.И. Савельева , Г.В. Каракашев , И.А. Васильева , Н.А. Самченко 
Published: December 2024

Завершив программу по уничтожению химического оружия (ХО) в сентябре 2017 года, Российская Федерация приступила к перепрофилированию объектов по уничтожению ХО (далее – предприятия УХО) для дальнейшего использования их в гражданских целях. Важным мероприятием при перепрофилировании предприятий УХО является оценка возможного остаточного загрязнения и выявления незафиксированных фактов контаминации инфраструктуры этих предприятий фосфорорганическими отравляющими веществами (ФОВ) или реакционными массами (РМ) от их. В настоящей работе представлена процедура многоцелевого скрининга 11 продуктов конверсии трех ФОВ нервно-паралитического действия: O-изобутил-S-(2-диэтиламиноэтил) метилфосфонотиоата (VR), изопропилового эфира фторангидрида метилфосфоновой кислоты (зарин, GB) и пинаколилового эфира фторангидрида метилфосфоновой кислоты (зоман, GD) и определение самого VR (как наиболее персистентного ФОВ нервно-паралитического действия) в строительных материалах. Скрининг всех аналитов, значительно различающихся по физико-химическим свойствам, проводится в рамках одного анализа методом высокоэффективной жидкостной хроматографии с тандемным масс-селективным детектированием (ВЭЖХ-МС/МС) и предлагается для использования при отборе смывов с поверхностей и твердых проб конструкционных материалов различного матричного состава.
After completing the program for the destruction of chemical weapons (CW) in September 2017, the Russian Federation began to re-profiling of CW destruction facilities for their further use for civilian purposes. An important measure in the re-profiling of these facilities is the assessment of possible residual contamination and the identification of unrecorded facts of contamination with organophosphorus toxic substances (OPT) or reaction masses (RM) from the neutralization of the infrastructure of the former CW destruction facilities. This paper presents a procedure for a multipurpose screening of 11 conversion products of three OP nerve agents: O-isobutyl-S-(2-diethylaminoethyl)methylphosphonothioate (VR), isopropyl ester of methylphosphonofluoridic acid (sarin, GB), and pinacolyl ester of methylphosphonofluoridic acid (soman, GD) and of VR itself (as the most persistent OP nerve agents) in building materials. Screening of all analytes that significantly differ in their physicochemical properties is carried out within a single analysis by high performance liquid chromatography with tandem mass-selective detection (HPLC-MS / MS) and is proposed for use in the selection of flushes from surfaces and solid samples of structural materials of various matrix composition.
Assessing the needs of healthcare providers to comply with the Sindh Health Service Providers and Facilities Act (2021) on violence prevention in Karachi, Pakistan.
Authors: Ali Syeda Tabeena , Muffadil Tasneem , Yasir Muhammad , Otho Muhammad Suleman , Siddiqui Muhammad Bilal 
Published: December 2024

Background: Workplace violence against healthcare providers is a serious issue in Pakistan. In 2021, the Government of Sindh enacted legislation titled “The Sindh Health Service Providers and Facilities (Prevention of Violence and Damage to Property) Act” to address this problem. This study aimed to assess the needs of healthcare providers in complying with this Act.
Methodology: A cross-sectional quantitative survey was conducted among 384 healthcare providers in emergency departments of selected public and private hospitals in Karachi. Data was collected using a structured questionnaire and analyzed using descriptive and inferential statistics.
Results: Significant gaps were identified in implementing security measures, incident reporting systems, staff training, and collaboration with law agencies, indicating the need for improvement. Key challenges reported were lack of resources, ethical issues in reporting, and inadequate response by authorities.
Conclusion: Targeted strategies are required to enhance healthcare providers’ capacity in compliance with the Violence Prevention Act. Priorities include policy dissemination, infrastructure upgrades, streamlined reporting and referral pathways, and training healthcare staff on legal rights and response protocols. Effective implementation of the Act can promote healthcare staff safety and delivery of quality care.
Pelatihan Pembuatan Botol Bambu Laminasi (Laminated Bamboo Bottles) Kelompok Wanita Tani Subur Desa Gondang Kabupaten Lombok Utara
Authors: Febriana Tri Wulandari  , Raehanayati  , Kornelia Webliana  , Diah Permata Sari  , Rima Vera Ningsih  
Published: December 2024

Pengabdian terkait bambu diawali dengan melakukan penelitian sifat fisika dan mekanika beberapa jenis bambu pada beberapa Kawasan yaitu HKM Aik bual, KHDTK Senaru dan Sumbawa pada tahun 2019 dan 2020, tahun 2021 melakukan pembuatan bambu menjadi papan laminasi dan tahun 2022 melakukan kegiatan pengabdian papan laminasi bambu menjadi produk cutting board bamboo (talenan bambu). Selain dapat meningkatkan nilai ekonomis bambu juga mendukung pemanfaatan bahan baku yang ramah lingkungan (eco green) dalam rangka mengurangi penggunaan bahan baku plastik. Pelatihan ini diharapkan mendukung pemanfaatan bahan baku yang ramah lingkungan, menambah lapangan kerja dan meningkatkan ekonomi masyarakat desa. Tujuan penyelenggaraan kegiatan ini yaitu: memberikan modul tahapan pengawetan bahan baku bambu dan pembuatan botol bambu laminasi, menyediakan peralatan pembuatan bahan pengawet untuk bahan baku bambu, menyediakan peralatan pembuatan botol bambu laminasi dan menyediakan peralatan packing botol bambu laminasi. Hasil kegiatan pengabdian menunjukan peserta sangat antusias untuk mengembangkan produk botol bambu karena teknologi yang mudah dan sederhana sehingga peserta mudah memahami dan mengembangkan produk tersebut. Pemberian modul berupa leaflet diharapkan dapat memudahkan peserta kelompok usaha wanita tani subur memahami tahapan dalam pembuatan botol bambu.
Analisis Kinerja Keuangan Sebelum dan Setelah Penerapan PSAK 22 Pada PT Sejahteraraya Anugrahjaya Tbk
Authors: Salsabila Anindiya 
Published: December 2024

Penelitian ini menjelaskan implementasi akuntansi kombinasi bisnis pada PT Sejahteraraya Anugrahjaya Tbk setelah penerapan PSAK 22 di tahun 2018 dan menggambarkan dampaknya terhadap kinerja keuangan perusahaan. Tujuan penelitian ini adalah untuk mengetahui signifikansi perbedaan kinerja keuangan perusahaan sebelum dan sesudah akuisisi pada periode 2013-2022, dengan menganalisis kinerja keuangan lima tahun sebelum dan lima tahun sesudah akuisisi. Sampel dalam penelitian ini menggunakan teknik nonpurposive sampling yaitu sampel jenuh. Dalam penelitian ini diperoleh 10 laporan keuangan yang menjadi sampel penelitian. Metode yang digunakan dalam penelitian ini adalah kuantitatif dengan menggunakan data sekunder dari laporan keuangan PT Sejahteraraya Anugrahjaya Tbk dan jenis penelitiannya berupa komparatif. Teknik pengumpulan menggunakan dokumentasi dan kepustakaan. Melalui analisis NPM, CR, DER, dan TATO hasil menunjukkan fluktuasi kinerja setelah akuisisi PT Bogor Medical Center terhadap PT Sejahteraraya Anugrahjaya Tbk. Teknik analisis yang digunakan adalah uji statistik deskriptif, uji normalitas, dan uji paired sample t-test dengan bantuan aplikasi SPSS 25 for windows.
PENGARUH KEPEMILIKAN KELEMBAGAAN, UKURAN DEWAN KOMISARIS, UKURAN PERUSAHAAN, DAN UKURAN KOMITE AUDIT TERHADAP PENGUNGKAPAN ISLAMIC SOCIAL REPORTING (ISR)
Authors: Maulita Dian , Dien Sefty Framitha  , Awalia  
Published: December 2024

Penelitian ini bertujuan untuk mengetahui pengaruh kepemilikan kelembagaan, ukuran dewan komisaris, ukuran perusahaan, dan ukuran komite audit terhadap pengungkapan islamic social reporting (ISR). Populasi dalam penelitian ini adalah perusahaan yang terdaftar di Jakarta Islamic index periode 2017-2021. Metode yang digunakan adalah purposive sampling sehingga 12 perusahaan yang menyajikan laporan keuangan lengkap sesuai dengan variabel yang diteliti dan di peroleh sebanyak 60 sampel perusahaan. Teknik analisis yang digunakan adalah analisis regresi berganda. Hasil penelitian menunjukan bahwa Kepemilikan Kelembagaan tidak berpengaruh terhadap pengungkapan Islamic Social Reporting (ISR), Ukuran Dewan Komisaris berpengaruh terhadap pengungkapan Islamic Social Reporting (ISR), Ukuran Perusahaan berpengaruh terhadap pengungkapan Islamic Social Reporting (ISR), dan Ukuran Komite Audit tidak berpengaruh terhadap pengungkapan Islamic Social Reporting (ISR).
O FENÔMENO DA BRANQUITUDE E A EDUCAÇÃO BÁSICA NO BRASIL
Authors: Carvalho Carlos José Moura de , Moraes Jorge Luiz Marques de 
Published: December 2024

Este trabalho pretende vincular o letramento racial/letramento racial crítico ao estudo da branquitude e da eugenia, levando-se em conta o contexto educacional brasileiro. Para isso, metodologicamente, são importantes reflexões e análises desses termos nos documentos que normatizam a Educação no Brasil, tais como a Lei de Diretrizes e a Base Nacional Comum Curricular. Este trabalho tem características de relato de experiência e de texto reflexivo. Diante das análises, ponderações sobre o tema foi possível chegarmos à conclusão de que a lei maior da educação e o normativo balizador dos currículos educacionais em âmbito nacional não direcionam profissionais de educação para reflexão e ações sobre eugenia e branquitude. É preciso um aprofundamento dos estudos para pensarmos a formação docente em busca do letramento racial crítico.
The Role of the Particle po- in the Comparison of Adjectives in Shtokavian Dialects
Authors: Trifunović Aleksandar 
Published: December 2024

The use of the particle po- with adjectives (and also adverbs) in either positive or comparative or even superlative form is fairly well present in Slavic languages. In Slovak for example, it is mostly used with terms for colours, carrying the meaning ʽlessʼ or ʽsomewhatʼ e.g. pobelavý ʽwhitish, somewhat whiteʼ ʽblackish, somewhat blackʼ, while in Czech it can either modify the meaning similar to that in Slovak e.g. pobělavý ʽwhitish, somewhat whiteʼ, or can be used with a comparative degree, carrying the meaning ʽless, slightly lessʼ e.g. postarší člověk ʽslightly less old manʼ. On the other hand, in Russian, it carries the meaning »more, even, slightly more, even more«, e.g. поинтереснее ʽeven more interestingʼ, постарша ʽeven olderʼ. At the very south of the Slavic language territory, i.e. in the Macedonian and Bulgarian languages, the use of the particle po- is the only mean of forming comparative degree of adjectives. In the Shtokavian dialects, the usage of the particle po- with adjectives consists of the whole spectrum of meaning. In some dialects it can be used with the positive degree e.g. povisok ʽpretty highʼ, the comparative degree e.g. poviši ʽa bit higher / a bit less highʼ - so the meaning can be the same as in Czech or Russian, depending on the dialect - and even superlative degree of an adjective ponajviši ʽhighest of the highestʼ. And on the other hand, there are dialects in which this is the only way of forming the comparative degree of adjectives – the same as in Macedonian and Bulgarian. In this article, all the variants of the usage of the particle po- in the Shtokavian dialects are presented, with the idea to establish the border between dialects that use this particle and those which do not use it. A substantial effort was put in order to find if there is any parallel between the shift from synthetic type of comparison to the analytic one in these dialects. This in return could shed a light in the further research of the same phenomenon in Bulgarian and Macedonian languages.
Aesthetic Constellations of Noah’s Ark
Authors: Deibl Jakob Helmut 
Published: December 2024

Abstract
This article considers Noah’s ark as a motif of the biblical text that travels through numerous other (not least philosophical) discourses. Not only have there been countless references to the motif of the ark in the biblically inspired tradition for centuries, it is also associated with the logical operations of encompassing the dispersed, the entry into reflection, and the aspect of order. The ark functions as a means, a house, a ship, a cave, a living environment, a symbol for language, etc. This article is itself modelled on an illustration in the medieval Beatus super Apocalypsim (The ‘Rylands Beatus’), which depicts the ark as a house of life. The order presented in the illustration suggests possible pathways through the article which leads to alternative ways of reading the contribution.
Bible and Philosophy
Authors: Appel Kurt , Heinrich Esther 
Published: December 2024

Abstract
The present volume ‘Bible and Philosophy’ subjects various biblical texts and motifs, including the fall of man, Noah’s ark, Jacob’s ladder, the Song of Songs, the resurrection of Jesus, the problem of human and divine violence, the singularity and recognisability of God and the Christian understanding of baptism to philosophical reflection. It is based on an understanding of philosophy that does not renounce the question of truth, but does not reduce truth to that which is quantifiable and measurable either. Biblical hermeneutics which closely links the question of truth to the question of the meaning of human existence and the question of justice is given particular consideration.
Las relaciones bilaterales Argentina-Chile. El impacto del contexto democrático y el incremento de contactos subnacionales
Authors: Colacrai Miryarn 
Published: December 2024

Este trabajo analiza, a través de variables fundamentalmente políticas, la evolución experitnentada por la re lación bilateral Argentina-Chile que, habiendo producido un salto cualitativo en la década del noventa, puede caracterizársela como de excepcionalidad positiva. Asigna especial relevancia a la existencia de un contexto democratico para que dichas relaciones se construyan , a la práctica de la "Diplomacia Presidencial", a la búsqueda de una relación que se piense en términos de alianza estratégica y al prolífico trabajo de actores subnacionales que vinculan crecientemente a los dos países.