bluuebunny/crossref_metadata_2025_split huggingface dataset:
AI-Powered Simulation Models for Estimating the Consolidation Settlement of Shallow Foundations
Authors: Jagan J , Samui Pijush 
Published: October 2024

Abstract

The shallow foundations are one of the commonly used, cost-effective and versatile substructure in the infrastructure and geotechnical society. The consolidation settlement is one of the influential parameters for the design purpose of the shallow foundation. This study utilized the AI based models like Deep Neural Network (DNN), Random Forest (RF) and Gradient Boosting Machine (GBM) for the prediction of Sc. In order to forecast the Sc, different soil conditions such as void ratio, compression index, density and the load were considered as the input criteria and their respective settlement is the output. These adopted AI driven models, provide better results with higher precisions. The output produced by the adopted models were considered for different statistical assessments, specifically, DNN model outperforms the other models in terms of precision (R2 = 0.9992) and less errors (RMSE = 0.6404). Moreover, the rank analysis, Taylor diagram and the reliability index were also computed for justifying the capability of the developed AI models.
Single-level lumbar osteoporotic compression fracture treated with unilateral approach percutaneous vertebroplasty via intervertebral foramen-A retrospective controlled study
Authors: Li Tao , Wang Zhihong , Zhang Tonghui , Tang Jin , Li Xugui , Xie Wei , Zhao Zhou , Huang He , Liu Liu , Gao Xuewei , Ji Peng 
Published: October 2024

Abstract

Purpose
To present a novel surgical strategy for the management of lumbar spine osteoporotic vertical compression fracture (OVCF).
Methods
182 patients with lumbar single segment OVCF who underwent PVP surgery between June 2020 and June 2021 were included in this retrospective study. Of them, 104 (as members of the bilateral group) received conventional bilateral puncture, while 78 (as members of the unilateral group) underwent unilateral PVP through the intervertebral foramen. Imaging results, follow-up clinical indicators, and perioperative period parameters were compared between the two groups.
Results
Both patient groups underwent the treatment effectively, with 39 instances in the bilateral group and 27 cases in the unilateral group reporting bone cement leakage; no serious issues, such as spinal cord or nerve injury, occurred. The unilateral group experienced shorter hospital stays, shorter X-ray exposure times during surgery, and lower overall costs (P < 0.05) than the bilateral group. There were no statistically significant differences between the two groups for any of these measures, which included postoperative ambulation time, hospitalization duration, and bone cement injection volume, distribution, and leakage. Two patient groups were followed for a total of 24–48 months, with an average follow-up of 31.97 ± 7.15 months. In the event that the patient breaks another bone while being monitored, the follow-up will terminate. For both patient groups, there was a significant decrease (P > 0.05) in VAS and ODI scores over time, and a significant increase (P < 0.05) in Japanese Orthopaedic Association (JOA) scores over time; however, there was no statistically significant difference (P > 0.05) in VAS, ODI, and JOA scores between the two groups at the corresponding time intervals. Comparing imaging data from postoperative patients in both groups to preoperative findings, there was a decrease in the local Cobb angle (P < 0.05) and an increase in the height of the anterior border of the injured vertebra (P < 0.05). At the comparable time point, there was no statistically significant difference (P > 0.05) in the anterior vertebral edge height and local Cobb angle between the two groups. The unilateral group's learning curve had a steeper slope.
Conclusion
While there is a learning curve associated with modified unilateral puncture PVP treatment for lumbar OVCF, it can also optimize surgical procedures and save expenses while achieving inspiring therapeutic outcomes.
Effect of different positions during surgical preparation on postoperative nausea and vomiting after thyroidectomy
Authors: GAO Liangliang , Tan Aiping , Lu Xinyu , Zhu Yi , Xu Yidan , Wei Lei 
Published: October 2024

Abstract

Study objective:
Despite being one of the most common adverse effects following thyroidectomy, there are currently no known effective preventive or therapeutic measures for postoperative nausea and vomiting (PONV). The purpose of this prospective randomised controlled trial is to assess if there is any correlation between postoperative nausea and vomiting in patients having thyroidectomy and the 20° Trendelenburg posture during surgical preparation.
Methods
180 patients undergoing elective thyroidectomy who were between 18 and 65 years old were randomly assigned to either the Trendelenburg position group or the supine position group. The patients were placed in the 20° Trendelenburg position following the induction of anesthesia in the Trendelenburg position group (TP group), and they were placed back in the supine position prior to the skin incision. The patient in the supine position group (SP group) remained in that position after anesthesia induction. The primary endpoint is the incidence of PONV within 24 hours after thyroidectomy. Secondary endpoints are systolic blood pressure at various times after induction of anesthesia, severity of nausea and vomiting, incidence of vomiting, incidence of nausea, severity of nausea, number of postoperative rescue antiemetics, and time to first vomiting within 24 hours after thyroidectomy.
Results
PONV occurred in 23.3% patients in TP group and 42.2% patients in SP group, TP group had significantly lower incidence and severity of PONV compared to SP group (P = 0.032) within 6 hours postoperatively. The occurrence and severity of PONV between 6 and 24 hours were not different between the two groups (P > 0.05). At three, five, and seven minutes after induction of anesthesia, SBP was significantly lower in the supine group than in the Trendelenburg group (P < 0.05). The incidence of nausea, the incidence of vomiting, and the number of rescue antiemetics in the TP group were lower than those in the SP group within 6 hours (P < 0.05). Kaplan-Meier curves showed that the time to first vomiting was longer in the TP group than in the SP group (P = 0.021).
Conclusion
The 20° Trendelenburg position during surgical preparation effectively reduced the incidence and severity of PONV within 6 hours, but had no effect on the incidence and severity of PONV between 6 and 24 hours after thyroidectomy.
Trial registration:
Chinese Clinical Trial Registry (ChiCTR2400084076, registered date: 10/05/2024), http://www.chictr.org.cn
The effect of RPLP1 on the proliferation and metastasis of neuroblastoma cells under the regulation of c-MYC
Authors: Qian Bo , Qian Ling , Ye Mingtang , Da Min , An Jia , Fang Yongjun , Mo Xuming , Sun Jing 
Published: October 2024

Abstract

Background
Neuroblastoma (NB) metastasis in high-risk patients is the most common cause of poor prognosis, but the mechanism of cancer metastasis is still unclear. RPLP1 is a member of a group of proteins called ribosomal proteins that are associated with tumor occurrence and metastasis. However, the expression and potential function of RPLP1 in NB are still unclear.
Methods
Bioinformatics methods were used to identify RPLP1 as a potential prognostic factor for NB. Real-time polymerase chain reaction and Western blotting were used to detect the expression of RPLP1 in NB tissues and cell lines to determine the correlation between RPLP1 expression and clinicopathological features. In vitro, we identified the role and mechanism of RPLP1 in NB cell line tumor metastasis.
Results
We detected high levels of RPLP1 expression in NB samples and cell lines. High expression levels are associated with an increased risk of recurrence and metastasis. In vitro experiments have shown that overexpression of RPLP1 promotes the metastatic ability of NB cells; in RPLP1 knockout cells, the opposite is true. In addition, the dual-luciferase reporter gene results indicated that RPLP1 is a potential downstream gene of MYC. MYC can promote the proliferation of NB cells by regulating the expression of RPLP1 and enhance cell metastasis through the epithelial mesenchymal transition (EMT) pathway.
Conclusion
In summary, our research revealed that RPLP1 is a potential biomarker and candidate therapeutic target for the poor prognosis of NB patients.
Defined neuroaspergillosis in immunocompetent patients following COVID-19 infection: two cases and literature review
Authors: Jianbo Chang , Ziyuan Liu , boju Pan , Jing Zhao , Ji Li , Dong Zhang , Guiren Ruan , Xiaojun Ma , Guojie Zhang , Xiao Zhang , Tao Mei , Ziyuan Fang , Junji Wei 
Published: October 2024

Abstract

In recent years, the advent of the SARS-Cov-2 pandemic has seen the emergence of neurological aspergillosis as a rare complication in immunocompetent patients infected with this pathogen. Neuroaspergillosis is a rare but serious infection of the central nervous system, typically observed in patients with compromised immune systems. This article presents a case series of two patients with aspergillosis associated with SARS-CoV-2 infection at Peking Union Medical College Hospital and offers a literature review on this topic. This study included two cases of neuroaspergillosis associated with SARS-CoV-2 infection. A search was conducted on PubMed for reports of neuroaspergillosis related to SARS-CoV-2, and a literature review was subsequently performed. The study examined the characteristics of the patients, the clinical manifestations, the treatment, and the prognosis. The findings revealed that the primary symptoms of neuroaspergillosis associated with SARS-CoV-2 infection included impaired consciousness, focal neurological deficits, and headaches, with a high mortality rate. The clinical diagnosis and treatment of the disease were challenging due to the difficulty of early detection and diagnosis. This study reviews the mechanism, clinical manifestations, diagnosis, and treatment strategies of neuroaspergillosis in immunocompetent patients after SARS-CoV-2 infection. Furthermore, it discusses the clinical characteristics of the disease through two cases. Early diagnosis and treatment are essential for effective management of the disease.
Prosthetic graft cut end aneurysm after total arch replacement: A case report
Authors: Furusawa Kohei , Kanaoka Yuji , Tanemoto Kazuo , Une Dai 
Published: October 2024

Abstract

Background
Closure of the cut end of prosthetic graft branch can also result in side branch aneurysms, depending on the method of ligation, which can lead to fatal complications
Case presentation
The patient was an 82-year-old man. He underwent total arch replacement (TAR) 13 years ago at another hospital for Stanford type A chronic aortic dissection. One branch of the four-branched graft for the arterial cannulation was ligated using silk thread after secession of extra-corporeal circulation. He was subsequently followed up at the outpatient department of the nearby hospital. A follow up CT scan revealed enlargement of the four-branched graft ligation site, and suture and closure of the prosthetic graft ligation site was performed under left thoracotomy. The edge of the ligated branch collapsed during dissection and was immediately clamped and closed. The Postoperative course was uneventful, and the patient was discharged from our hospital on postoperative day 13. The patient has been followed up without any complications including recurrence of aneurysm for 4 years since operation.
Conclusion
Healing mechanisms do not work in anastomosis between prosthetic grafts. The material used such as silk thread may deteriorate over time causing failure. Therefore, it is necessary to use polypropylene or polyester thread for suture and closure.
Homotypic cell-in-cell structures as a prognostic factor in intrahepatic cholangiocarcinoma post-hepatectomy and a predictor of responses to PD-1 inhibitor treatment：a retrospective cohort study
Authors: Chen Yu-Sen , Li Jian-Hui , Li Yi-Hu , Yang Wei-Bang , Xu Jin-Yang , Wei Yu-Xuan , Huang Si-Min , Wang Qi-Wen , Jiang Xiao-Feng 
Published: October 2024

Abstract

Background
There lacks an effective histomorphological predictive option for dismal outcome of intrahepatic cholangiocarcinoma (iCCA). This study aims to evaluate the prognosis and anti-PD 1 therapy effect of iCCA patients with radical resection through the occurrence of homotypic cell-in-cell structure (hoCIC) phenomenon.
Methods
The study collected biological specimens and clinical data from iCCA patients who underwent radical resection from January 2015 to December 2023. We performed an analysis of hoCICs profiling in iCCA biopsy using "epithelium-macrophage-leukocyte" (EML) multiplex staining. Subsequently, we investigate the feasibility of utilizing hoCICs as a functional biomarker for predicting prognosis and responses to PD-1 inhibitor treatment in patients with iCCA through Kaplan-Meier plotting and Cox regression model.
Results
A total of 34 patients with iCCA were included in the study, with a median follow-up of 37 months. The results of multivariable Cox analysis revealed that TiT (tumor cell inside tumor cell) counts ≥ 3 were independently associated with overall survival (OS) with a hazard ratio (HR) of 3.815 (P = 0.0293) and recurrence-free survival (RFS) with a HR of 3.547 (P = 0.0290), respectively. 11 of the 34 iCCA patients received postoperative anti-PD1 treatment. The log-rank test result showed that the recurrence-free survival (RFS) of TiT counts ≥ 3 group was significantly shorter than that of the TiT counts < 3 group, revealing a HR of 4.308 (P = 0.0301). These results indicated that lower TiT level had a better response to postoperative anti-PD1 treatment.
Conclusions
The current study highlights hoCICs as a potential adverse prognostic biomarker in patients with iCCA. Furthermore, hoCICs may serve as predictive indicators for the treatment response to postoperative anti-PD1 therapy, based on recurrence-free survival (RFS).
How Bronze Drum Patterns Influence Chinese Art and Cultural Identity: A systematic literature review
Authors: Chen Shanyu , Ismail Nor Atiah binti , Hussain Norhuzailin binti , Lin Guangbo 
Published: October 2024

Abstract

Since the bronze drum custom was rated as a national intangible cultural heritage in 2006, the research on bronze drum patterns and Chinese art and cultural identity has continued to increase. However, previous research still needs to be completed. No research comprehensively reviews the influence of bronze drum patterns on Chinese art and cultural identity. Given this, this study adopts a systematic literature review method to highlight the latest status of these studies. It studies the latest published and screens 29 studies on the influence of bronze drum patterns on Chinese art and cultural identity in four databases: Scopus, Google Scholar, ProQuest and CNKI. The research findings are as follows: (1) The way bronze drum patterns influence the cultural identity of Chinese art focuses more on innovation and integration in modern art, followed by the profound connotation of ethnic and regional cultural symbols and the significance of cultural symbols. (2) The research on bronze drum patterns on Chinese art and cultural identity tends to be more inclined to design research in the research field; the research content tends to be more inclined to bronze drum culture, bronze drum patterns and application research on value and design; in terms of research methods, case studies are the majority, followed by qualitative research. Based on the above literature review, a valuable future agenda is provided regarding the research field, content, and methods, thus providing theoretical support for the more profound development of this research direction.
Spin Seebeck in the weak exchange coupled van der Waals antiferromagnet
Authors: Wu Rui , He Xue , Ding Shilei , Giil Hans , Wang Jicheng , Lin Zhongchong , Liang Zhongyu , Yang Jinbo , Kläui Mathias , Brataas Arne , Hou Yanglong 
Published: October 2024

Abstract

Spin Seebeck effect (SSE) refers to the creation of spin currents due to a temperature gradient in the magnetic materials or across magnet-normal metal interfaces, which can be electrically detected through the inverse spin Hall effect (ISHE) when in contact with heavy metals. It offers fundamental insights into the magnetic properties of materials, including the magnetic phase transition, static magnetic order, and magnon excitations. However, the SSE in van der Waals antiferromagnet is still elusive, especially across the spin-flip transition. Here, we demonstrate the SSE in the weak exchange coupled van der Waals antiferromagnet CrPS4. The SSE increases as the magnetic field increases before the spin-flip transition due to the enhancement of the thermal spin current as a function of the applied field. A peak of SSE is observed at the spin-flip field, which is related to the magnon mode edges across the spin-flip field. Our results extend SSE research to van der Waals antiferromagnets and demonstrate an enhancement of SSE at the spin-flip transition.
Evaluating the effects of subcapsular hematoma on the kidney in an in vivo porcine model
Authors: Xu Yuexian , Huang Qingfeng , Qi Qiao , He Qiushi , Hou Bingbing , Hao Zongyao 
Published: October 2024

Abstract

Objectives
The pathophysiological changes in the kidney resulting from subcapsular renal hematoma (SRH) are still unclear. We explored this issue by establishing an in vivo porcine SRH model.
Materials and Methods
The SRH model was constructed by injecting autologous blood (0, 10, 20, 40, or 80 ml) under the renal capsules of pigs that were sacrificed at 14 days. We evaluated the pathophysiological impact of subcapsular hematoma on the kidney by detecting the renal injury markers KIM1 and NGAL, as well as inflammation and fibrosis-related indicators, in both renal pelvis urine and kidney tissue using ELISA, H&E staining, periodic acid-Schiff (PAS) staining, immunohistochemical (IHC) staining, RT-PCR, and Western blotting.
Results
KIM1 and NGAL levels in renal pelvic urine started to increase when the volume of SRH reached 20 ml, rather than 10 ml, with the most pronounced increase occurring when it reached 80 ml. Similarly, HE and PAS staining showed that pathological damage to the kidneys had begun at 20 ml; IHC, RT-PCR, and Western blotting further confirmed the presence of inflammation and fibrosis in the kidneys, which increased in severity with increasing SRH volume.
Conclusions
SRH volumes up to 20 ml can induce renal injury and fibrosis. Drainage of the hematoma may be more reasonable in those patients with even asymptomatic large volumes of SRH rather than in those who are undergoing observation.
Clinical Efficacy of the Ilizarov Technique in the Treatment of Infected Non Union And Bone Defects Results of at least 2 Years of Follow-up.
Authors: Rizvi S M Mahamudul Hassan , Aihemaiti Shami· , Hui Liu , Tao Shengxiang 
Published: October 2024

Abstract

Background:
Surgical technique and preliminary clinical results using the Ilizarov Technique in the Treatment of Infected Non Union and Bone Defects. In order to address the issues related to non-union, including bone gap, bone defect and infection an Ilizarov external fixator was used. In order to achieve nonunion, bone defects and repair the limb length difference, stable fixation, corticotomy, and bone transfer were used to decrease or eradicate infection.
Methods:
Clinical data were collected on patients with infected bone defects and bone shortening deformities treated with Ilizarov bone transfer technology at Wuhan University Zhongnan Hospital from January 2021 to December 2023. The clinical data of 24 cases 16 males and 8 females with bone defect treated by Ilizarov bone transport were analyzed prospective observational research. The results were analyzed using the ASAMI scoring system.
Results:
Out of 24 Patient the results of skeletal outcomes 14 cases had Excellent,7cases result good 3 cases had moderate results. In terms of functional outcome. The results of 10 patients had an outstanding performance, 8 patients had a good performance, 4 patients had average performance and 2 patients had poor performance. The average fixed period was 11.16 months (min 8 months, max 14 months). The average length of regrowth is 5.67 cm (min 3.98cm, max 6.97cm). The survey found that the average elongation index was 1.94 months/cm.
Conclusion:
The Ilizarov bone transfer technique can achieve satisfactory results in the treatment of infected Nonunion and bone defects. Ilizarov bone transfer technique can safely and effectively shorten bone healing time, improve the healing index, and significantly improve a patient’s quality of life.
Movement behaviours, air pollution and health in school-aged children: a cross-sectional study to guide the co- creation of healthier environments - The MOVE-AIR Project
Authors: Martins Clarice , Rufo João , Padrão Ana , Fonseca Hélder , Batista Liliana , Santos Maria Paula , Zacca Rodrigo , Silva José Pedro , Ribeiro Ana Isabel 
Published: October 2024

Abstract

The MOVE-Air study was designed to explore the role of movement behaviours on the association between air pollutants and health outcomes in Portuguese children. Secondarily, it aims to characterize the settings (both indoor and outdoor) where children are exposed to air pollutants and to co-create solutions with participants to mitigate the exposure to air pollutants in children´s daily life. This study aims to detailed describe the MOVE-AIR study protocol. Data from at least 22 primary school children aged 9-to-11 years will be assessed for indoor and outdoor air pollutants (PM2.5 and PM10, and carbon dioxide), geo-tracked for distinct settings (i.e., home/school, indoor/ outdoor) along the day, through an optical monitoring sensor with global position system incorporated. Health-related biological outcomes, such as Interleukin 6 (IL6), Tumor Necrosis Factor Alpha (TNF- α), and oxidative parameters, including Total Antioxidant Status (TAS), and Total Oxidant Status (TOS) will be evaluated, and the Oxidative Stress Index (OSI) will be calculated. Children´s cardiopulmonary fitness will be assessed through the Shuttle-run Test, and movement behaviours will be evaluated through accelerometers (wGT3-x). Children´s sex, age, and parental socioeconomic status will be provided by parents through a questionnaire. The influence of movement behaviours in the link between pollution and health will be analyzed through compositional analysis and structural equation models using R software (4.2.0). A sub-sample of class teachers, school leaders, parents, and children will be invited to a co-creation process to create solutions to mitigate their daily exposure to air pollutants. The results will contribute to further understanding the influence of movement behaviours in the association between air pollution and health, adding a biological layer to the mechanistic links underlying these potential relationships that have not been explored in this target population. Finally, enhancing our comprehension of the living environments and contexts where children are more exposed to air pollution can help to cooperatively create solutions to mitigate their daily exposure to those harmful pollutants.