bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of the Burden of Multidrug-Resistant Healthcare-Associated Infections Among Intensive Care Unit Patients in Southeast Asia: The Rise of Multidrug-ResistantAcinetobacter baumannii
Authors: Teerawattanapong Nattawat , Panich Pornpansa , Kulpokin Disorn , Na Ranong Siriwat , Kongpakwattana Khachen , Saksinanon Atibodi , Goh Bey-Hing , Lee Learn-Han , Apisarnthanarak Anucha , Chaiyakunapruk Nathorn 
Published: March 2018

OBJECTIVETo summarize the clinical burden (cumulative incidence, prevalence, case fatality rate and length of stay) and economic burden (healthcare cost) of healthcare-associated infections (HAIs) due to multidrug-resistant organisms (MDROs) among patients in intensive care units (ICUs) in Southeast Asia.DESIGNSystematic review.METHODSWe conducted a comprehensive literature search in PubMed, EMBASE, CINAHL, EconLit, and the Cochrane Library databases from their inception through September 30, 2016. Clinical and economic burdens and study quality were assessed for each included study.RESULTSIn total, 41 studies met our inclusion criteria; together, 22,876 ICU patients from 7 Southeast Asian countries were included. The cumulative incidence of HAI caused byA. baumannii(AB) in Southeast Asia is substantially higher than has been reported in other regions, especially carbapenem-resistant AB (CRAB; 64.91%) and multidrug-resistant AB (MDR-AB) (58.51%). Evidence of a dose–response relationship between different degrees of drug resistance and excess mortality due to AB infections was observed. Adjusted odds ratios were 1.23 (95% confidence interval [CI], 0.51–3.00) for MDR-AB, 1.72 (95% CI, 0.77–3.80) for extensively drug-resistant AB (XDR-AB), and 1.82 (95% CI, 0.55–6.00) for pandrug-resistant AB (PDR-AB). There is, however, a paucity of published data on additional length of stay and costs attributable to MDROs.CONCLUSIONSThis review highlights the challenges in addressing MDROs in Southeast Asia, where HAIs caused by MDR gram-negative bacteria are abundant and have a strong impact on society. With our findings, we hope to draw the attention of clinicians and policy makers to the problem of antibiotic resistance and to issue a call for action in the management of MDROs.Infect Control Hosp Epidemiol2018;39:525–533
From Locke to Slots: Money and the Politics of Indigeneity
Authors: Cattelino Jessica R. 
Published: March 2018

AbstractWith ongoing consequences for American Indians, the New World Indian has been a pervasive figure of constitutive exclusion in modern theories of money, property, and government. This paradoxical exclusion of indigenous peoples from the money/property/government complex is intrinsic to, and constitutive of, modern theories of money. What is more, it haunts the cultural politics of indigenous peoples’ economic actions. In Part I, I establish that, and how, indigeneity has been constitutively present at the foundation of modern theories of money, as Europeans and settlers defined indigenous peoples in part by the absence of money and property (of which money is a special form). In turn, and more to the point here, they defined money and property in part as that which modern non-indigenous people have and use. These are not solely economic matters: the conceptual exclusions from money/property were coproduced with juridical ones insofar as liberal political theory grounded the authority of modern government in private property (and, in turn, in money). To show how this formation of money and indigeneity has mattered both for disciplinary anthropology and for American public culture at several historical moments, Part II traces how the dilemmas expressed by these texts haunt subsequent debates about the function of wampum, the logic of potlatch, and the impact of tribal gaming. Such debates inform scholarship beyond the boundaries of anthropology and, as each case shows in brief, they create harms and benefits for peoples in ways that perpetuate the (il)logics and everyday practices of settler colonialism.
Indigenous Conflict in Bolivia Explored through an African Lens: Towards a Comparative Analysis of Indigeneity
Authors: Canessa Andrew 
Published: March 2018

AbstractSince Evo Morales was first elected President of Bolivia in 2005, indigeneity has moved from being a language of protest to a language of governance with concomitant profound changes in how indigeneity is imagined and mobilized. However, one of the striking features of Morales's presidency is his administration's open conflict with various indigenous groups. Although a number of scholars have addressed these issues, they have largely focused on the peculiarities of the Bolivian example in a Latin American context; this has obscured the advantage of significant comparative analysis with other areas of the world. I argue that indigeneity as it is currently practiced and understood is a recent global phenomenon and that there are more similarities between African countries and Bolivia than is generally appreciated. In particular, scholarly debates surrounding the difference between autochthony and indigeneity, and the case of Cameroon in particular, have much to offer in our understanding of the Bolivian case. To date, the primary frame for understanding indigeneity is an ethnic/cultural one and this can obscure important similarities and differences between groups. The comparative framework presented here allows for the development of analytical tools to distinguish fundamental differences and conflicts in indigenous discourses. I distinguish between five related conceptual pairs: majoritarian and minoritarian discourses; claims on the state and claims against the state; de-territorialized peoples versus territorialized peoples; hegemonic and counterhegemonic indigeneity; and substantive versus symbolic indigeneity. These nested pairs allow for analytic distinctions between indigenous rights discourses without recourse to discussions of culture and authenticity.
Recombinant adenylate kinase 3 from liver fluke Clonorchis sinensis for histochemical analysis and serodiagnosis of clonorchiasis
Authors: Kwon Soon Bin , Kim Paul , Woo Hae Sun , Kim Tae Yun , Kim Ju Yeong , Lee Hye Min , Jang Yun Soo , Kim Eun-Min , Yong Tai-Soon , Seong Baik Lin 
Published: March 2018

AbstractDue to the lack of an effective prophylactic intervention and diagnosis, human liver fluke Clonorchis sinensis continues to afflict a large human population, causing a chronic inflammatory bile duct disease. With an aim to identify target antigens for sensitive serodiagnosis, adenylate kinase 3 of C. sinensis (CsAK3) was successfully expressed in soluble form in Escherichia coli by fusion to an RNA-interacting domain derived from human Lys-tRNA synthetase and purified by Ni2+-affinity chromatography. Anti-CsAK3 serum was raised by immunization of mice, and Western blotting confirmed that CsAK3 was expressed in adult-stage C. sinensis. Histochemical analysis showed that CsAK3 was localized to the subtegumental tissue of C. sinensis and was excreted into the bile duct of the host. When tested against sera from various parasite-infected patients by enzyme-linked immunosorbent assay, the recombinant CsAK3 elicited a specific response to C. sinensis-infected sera. The results suggest that CsAK3, either alone or in combination with other antigens, could be used for improving the clinical diagnosis of clonorchiasis.
Healthy changes in some cardiometabolic risk factors accompany the higher summertime serum 25-hydroxyvitamin D concentrations in Iranian children: National Food and Nutrition Surveillance
Authors: Nikooyeh Bahareh , Abdollahi Zahra , Hajifaraji Majid , Alavi-Majd Hamid , Salehi Forouzan , Yarparvar Amir Hossein , Neyestani Tirang R 
Published: March 2018

AbstractObjectiveTo investigate seasonal variations of vitamin D status at different latitudes and if these changes are accompanied by corresponding variations in certain health parameters in children living in a broad latitudinal range in Iran.DesignLongitudinal study.SubjectsIn total, 530 apparently healthy children aged 5–18 years were randomly selected from six regions of Iran with a latitudinal gradient from 29°N to 37·5°N. All anthropometric and biochemical assessments were performed twice during a year (summer, winter). High BMI (Z-score >1), low HDL cholesterol (<40 mg/dl, males; <50 mg/dl, females) and high TAG (>150 mg/dl) were considered cardiometabolic risk factors.ResultsSerum 25-hydroxyvitamin D (25(OH)D) showed between-season variation, with significantly higher concentrations (mean (sd)) in summerv. winter (43 (29)v.27 (18) nmol/l;P<0·001). Change of circulating 25(OH)D between summer and winter was negatively correlated with change of BMI (r=−0·16;P<0·001), TAG (r=−0·09;P=0·04) and total cholesterol (r=−0·10;P=0·02) and directly correlated with change of height-for-ageZ-score (r=0·09;P=0·04). Multiple stepwise linear regression analysis (β; 95 % CI) showed that winter serum 25(OH)D (−0·3; −0·4, −0·2;P<0·001), gender (boysv.girls: 9·7; 5·2, 14·1;P<0·001) and latitude (>33°Nv.<33°N: 4·5; 0·09, 9·0;P=0·04) were predictors of change of serum 25(OH)D between two seasons.ConclusionsSummertime improvement of vitamin D status was accompanied by certain improved cardiometabolic risk factors, notably serum TAG, total cholesterol and BMI, in children.
BLOND, a building-level office environment dataset of typical electrical appliances
Authors: Kriechbaumer Thomas , Jacobsen Hans-Arno 
Published: March 2018

AbstractEnergy metering has gained popularity as conventional meters are replaced by electronic smart meters that promise energy savings and higher comfort levels for occupants. Achieving these goals requires a deeper understanding of consumption patterns to reduce the energy footprint: load profile forecasting, power disaggregation, appliance identification, startup event detection, etc. Publicly available datasets are used to test, verify, and benchmark possible solutions to these problems. For this purpose, we present the BLOND dataset: continuous energy measurements of a typical office environment at high sampling rates with common appliances and load profiles. We provide voltage and current readings for aggregated circuits and matching fully-labeled ground truth data (individual appliance measurements). The dataset contains 53 appliances (16 classes) in a 3-phase power grid. BLOND-50 contains 213 days of measurements sampled at 50kSps (aggregate) and 6.4kSps (individual appliances). BLOND-250 consists of the same setup: 50 days, 250kSps (aggregate), 50kSps (individual appliances). These are the longest continuous measurements at such high sampling rates and fully-labeled ground truth we are aware of.
Vocal Emotion Identification by Children Using Cochlear Implants, Relations to Voice Quality, and Musical Interests
Authors: Waaramaa Teija , Kukkonen Tarja , Mykkänen Sari , Geneid Ahmed 
Published: March 2018

PurposeListening tests for emotion identification were conducted with 8–17-year-old children with hearing impairment (HI;N= 25) using cochlear implants, and their 12-year-old peers with normal hearing (N= 18). The study examined the impact of musical interests and acoustics of the stimuli on correct emotion identification.MethodThe children completed a questionnaire with their background information and noting musical interests. They then listened to vocal stimuli produced by actors (N= 5) and consisting of nonsense sentences and prolonged vowels ([a:], [i:], and [u:];N= 32) expressing excitement, anger, contentment, and fear. The children's task was to identify the emotions they heard in the sample by choosing from the provided options. Acoustics of the samples were studied using Praat software, and statistics were examined using SPSS 24 software.ResultsThe children with HI identified the emotions with 57% accuracy and the normal hearing children with 75% accuracy. Female listeners were more accurate than male listeners in both groups. Those who were implanted before age of 3 years identified emotions more accurately than others (p< .05). No connection between the child's audiogram and correct identification was observed. Musical interests and voice quality parameters were found to be related to correct identification.ConclusionsImplantation age, musical interests, and voice quality tended to have an impact on correct emotion identification. Thus, in developing the cochlear implants, it may be worth paying attention to the acoustic structures of vocal emotional expressions, especially the formant frequency of F3. Supporting the musical interests of children with HI may help their emotional development and improve their social lives.
The Impact of Lexical Characteristics and Noise on Intelligibility of Parkinsonian Speech
Authors: Chiu Yi-Fang , Forrest Karen 
Published: March 2018

PurposeThis study investigated the impact of lexical characteristics on the intelligibility of speakers with Parkinson's disease (PD). Intelligibility was compared for listening in a quiet versus a noisy environment.MethodA total of 192 young listeners participated in the study, with 96 listeners listening in quiet and 96 listening in noise in which the spoken sentences were mixed with 10-talker babble. The listeners transcribed spoken sentences with target words controlled for word frequency and neighborhood density. The sentences were produced by 12 speakers with PD and 12 healthy control (HC) speakers. Transcription accuracy was compared across lexical categories between PD and HC and between the two listening conditions.ResultsTranscription accuracy was higher for high-frequency words than low-frequency words for both speaker groups in quiet and in noise. The neighborhood density effect was evident only in the noise condition with better intelligibility for words from sparse neighborhoods than from dense neighborhoods. Regardless of listening condition, the PD group was less intelligible with a significant decrease in intelligibility in noise relative to quiet.ConclusionsThe lexical properties of the words affected listeners' understanding of Parkinsonian speech. Frequent words in sparse neighborhood enhanced intelligibility, especially under adverse listening conditions. Babble noise had a detrimental impact on the intelligibility of Parkinsonian speech. The extent of the lexical effect on intelligibility increased in noise.
Measuring the Diagnostic Features of Social (Pragmatic) Communication Disorder: An Exploratory Study
Authors: Yuan Haiying , Dollaghan Christine 
Published: March 2018

Purpose

The
Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
introduced a new neurodevelopmental disorder, social (pragmatic) communication disorder (SPCD), that is characterized by deficits in 4 areas of communication. Although descriptions of these areas are provided, no assessment tools for SPCD are recommended. The purpose of this study was to examine the extent to which items from measurement tools commonly used in assessing pragmatic language impairment and related disorders might be useful in assessing the characteristics of social communication that define SPCD in the
Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
.

Method
Based on a literature search, 594 items from assessment tools commonly used to measure social communication abilities in people with pragmatic language impairment were identified. The first author judged whether each item reflected 1, more than 1, or none of the 4 SPCD diagnostic characteristics. After a brief training process, 5 second raters independently mapped subsets of items to the 6 categories. We calculated the percentage of agreement and Cohen's kappa for each pair of raters in assigning items to categories.

Results
Percentages of agreement ranged from 76% to 82%, and Cohen's kappa values ranged from .69 to .76, indicating substantial agreement. Sources and item numbers for the 206 items that both raters assigned to the same SPCD feature are provided.

Conclusions
These items may provide guidance in assessing SPCD and in designing standardized screening and diagnostic measures for SPCD.
Constraint on ion–neutral drift velocity in the Class 0 protostar B335 from ALMA observations
Authors: Yen Hsi-Wei , Zhao Bo , Koch Patrick M. , Krasnopolsky Ruben , Li Zhi-Yun , Ohashi Nagayoshi , Takakuwa Shigehisa 
Published: March 2018

Aims. Ambipolar diffusion can cause a velocity drift between ions and neutrals. This is one of the non-ideal magnetohydrodynamics (MHD) effects proposed to enable the formation of large-scale Keplerian disks with sizes of tens of au. To observationally study ambipolar diffusion in collapsing protostellar envelopes, we compare here gas kinematics traced by ionized and neutral molecular lines and discuss the implication on ambipolar diffusion.
Methods. We analyzed the data of the H13CO+ (3–2) and C18O (2–1) emission in the Class 0 protostar B335 obtained with our ALMA observations. We constructed kinematical models to fit the velocity structures observed in the H13CO+ and C18O emission and to measure the infalling velocities of the ionized and neutral gas on a 100 au scale in B335.
Results. A central compact (~1′′–2′′) component that is elongated perpendicular to the outflow direction and exhibits a clear velocity gradient along the outflow direction is observed in both lines and most likely traces the infalling flattened envelope. With our kinematical models, the infalling velocities in the H13CO+ and C18O emission are both measured to be 0.85 ± 0.2 km s−1 at a radius of 100 au, suggesting that the velocity drift between the ionized and neutral gas is at most 0.3 km s−1 at a radius of 100 au in B335.
Conclusions. The Hall parameter for H13CO+ is estimated to be ≫1 on a 100 au scale in B335, so that H13CO+ is expected to be attached to the magnetic field. Our non-detection or upper limit of the velocity drift between the ionized and neutral gas could suggest that the magnetic field remains rather well coupled to the bulk neutral material on a 100 au scale in this source, and that any significant field-matter decoupling, if present, likely occurs only on a smaller scale, leading to an accumulation of magnetic flux and thus efficient magnetic braking in the inner envelope. This result is consistent with the expectation from the MHD simulations with a typical ambipolar diffusivity and those without ambipolar diffusion. On the other hand, the high ambipolar drift velocity of 0.5–1.0 km s−1 on a 100 au scale predicted in the MHD simulations with an enhanced ambipolar diffusivity by removing small dust grains, where the minimum grain size is 0.1 μm, is not detected in our observations. However, because of our limited angular resolution, we cannot rule out a significant ambipolar drift only in the midplane of the infalling envelope. Future observations with higher angular resolutions (~0. ′′1) are needed to examine this possibility and ambipolar diffusion on a smaller scale.
Reactive collision of electrons with CO+ in cometary coma
Authors: Moulane Y. , Mezei J. Zs. , Laporta V. , Jehin E. , Benkhaldoun Z. , Schneider I. F. 
Published: March 2018

Context. In order to improve our understanding of the kinetics of the cometary coma, theoretical studies of the major reactive collisions in these environments are needed. Deep in the collisional coma, inelastic collisions between thermal electrons and molecular ions result in recombination and vibrational excitation, the rates of these processes being particularly elevated due to the high charged particle densities in the inner region.
Aims. This work addresses the dissociative recombination, vibrational excitation, and vibrational de-excitation of electrons with CO+ molecular cations. The aim of this study is to understand the importance of these reactive collisions in producing carbon and oxygen atoms in cometary activity.
Methods. The cross-section calculations were based on multichannel quantum defect theory. The molecular data sets, used here to take into account the nuclear dynamics, were based on ab initio R-matrix approach.
Results. The cross-sections for the dissociative recombination, vibrational excitation, and vibrational de-excitation processes, for the six lowest vibrational levels of CO+ – relevant for the electronic temperatures observed in comets – are computed, as well as their corresponding Maxwell rate coefficients. Moreover, final state distributions for different dissociation pathways are presented.
Conclusions. Among all reactive collisions taking place between low-energy electrons and CO+, the dissociative recombination is the most important process at electronic temperatures characterizing the comets. We have shown that this process can be a major source of O(3P), O(1D), O(1S), C(3P) and C(1D) produced in the cometary coma at small cometocentric distances.
Die Rolle von Biomarkern in Diagnose, Prognose und Therapie von Patienten unter immunonkologischer Therapie mit urologischen Malignomen
Authors: Compérat Eva , Eymerit Caroline , Moroch Julien , Varinot Justin 
Published: March 2018

ZusammenfassungIn den letzten Jahren haben Fortschritte in der Grundlagenforschung neue Einsichten in die Tumorbiologie gestattet, dadurch konnten neue Therapien entwickelt werden. Diese Übersichtsarbeit beleuchtet die Rolle des Pathologen und wie er anhand von Gewebemarkern helfen kann, eine Therapieentscheidung zu treffen. Wir erklären die Problematik der molekularen Blasentumoruntergruppen, die Rolle der neoadjuvanten Chemotherapie und die der Immune Checkpoint Inhibitoren, des Weiteren gehen wir auf das Nierenkarzinom und dessen Therapiemöglichkeiten ein, mit besonderem Augenmerk auf das klarzellige Nierenkarzinom als häufigsten Nierenkarzinomtyp. Wir streifen kurz das Prostatakarzinom, das als hormonabhängiger Tumor wahrscheinlich einen anderen Therapieansatz braucht. Wir versuchen, die Machbarkeit und Grenzen vom pathologischen Standpunkt her zu beleuchten.
Immuntherapie mit Checkpoint-Inhibitoren beim lokal fortgeschrittenen und metastasierten Urothelzellkarzinom
Authors: Miller Kurt , Gschwend Jürgen , Merseburger Axel , Retz Margitta , Stenzl Arnulf 
Published: March 2018

ZusammenfassungCheckpoint-Inhibitoren haben in der bislang limitierten Therapie des Urothelzellkarzinoms eine neue Ära eingeleitet. Dies spiegelt sich in der aktuellen S3-Leitlinie zum Harnblasenkarzinom derzeit noch nicht wider. Da es sich bei der Krebsimmuntherapie um ein neues Therapieprinzip handelt, stellen sich gegenwärtig Fragen für den Praxisalltag: Auf welchen Daten beruhen die Zulassungen der einzelnen Wirkstoffe? Wie verändern sich die Therapiealgorithmen? Worauf muss beim Therapiemanagement geachtet werden? Welche Nebenwirkungen können auftreten, wie lassen sie sich erkennen und behandeln? Die vorliegende Publikation verfolgt das Ziel, diese Fragen zu beantworten.
Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles
Authors: Yanez Arteta Marianna , Kjellman Tomas , Bartesaghi Stefano , Wallin Simonetta , Wu Xiaoqiu , Kvist Alexander J. , Dabkowska Aleksandra , Székely Noémi , Radulescu Aurel , Bergenholtz Johan , Lindfors Lennart 
Published: March 2018

Significance
mRNA treatments represent an exciting approach to cure diseases that cannot be tackled with current therapeutics. However, the delivery of mRNA to target cells remains a challenge, but among the existing alternatives, lipid nanoparticles (LNPs) offer a promising answer to this. Here we determine the structure of LNPs encapsulating mRNA, consisting of a lipid mixture already evaluated in clinical trials. We show that the lipids are not homogeneously distributed across the LNP, and one of the lipids is localized mainly at its surface. The structural information enabled us to design LNPs that successfully modify intracellular protein production in two clinically relevant cell types. Our findings and approach provide a framework for understanding and optimizing vehicles for mRNA delivery.