bluuebunny/crossref_metadata_2025_split huggingface dataset:
Culturally responsive strategies and practical considerations for live tissue studies in Māori participant cohorts
Authors: Abolins-Thompson Helena , Henare Kimiora L. , Simonson Bridget , Chaffin Mark , Ellinor Patrick T. , Henry Claire , Haimona Mairarangi , Aitken Jake , Parai Taku , Elkington Bianca , Rongo Michael , Danielson Kirsty M. , Leask Megan P. 
Published: November 2024

IntroductionIndigenous communities globally are inequitably affected by non-communicable diseases such as cancer and coronary artery disease. Increased focus on personalized medicine approaches for the treatment of these diseases offers opportunities to improve the health of Indigenous people. Conversely, poorly implemented approaches pose increased risk of further exacerbating current inequities in health outcomes for Indigenous peoples. The advancement of modern biology techniques, such as three-dimensional (3D) in vitro models and next generation sequencing (NGS) technologies, have enhanced our understanding of disease mechanisms and individualized treatment responses. However, current representation of Indigenous peoples in these datasets is lacking. It is crucial that there is appropriate and ethical representation of Indigenous peoples in generated datasets to ensure these technologies can be used to maximize the benefit of personalized medicine for Indigenous peoples.MethodsThis project discusses the use of 3D tumor organoids and single cell/nucleus RNA sequencing to study cancer treatment responses and explore immune cell roles in coronary artery disease. Using key pillars from currently available Indigenous bioethics frameworks, strategies were developed for the use of Māori participant samples for live tissue and sequencing studies. These were based on extensive collaborations with local Māori community, scientific leaders, clinical experts, and international collaborators from the Broad Institute of MIT and Harvard. Issues surrounding the use of live tissue, genomic data, sending samples overseas and Indigenous data sovereignty were discussed.ResultsThis paper illustrates a real-world example of how collaboration with community and the incorporation of Indigenous worldviews can be applied to molecular biology studies in a practical and culturally responsive manner, ensuring fair and equitable representation of Indigenous peoples in modern scientific data.
BEVACIZUMAB VS RANIBIZUMAB IN MACULAR EDEMA DUE TO RETINAL VEIN OCCLUSION: SHORT-TERM OUTCOMES
Authors: Kurniawan Chalid 
Published: November 2024

Introduction and Objective: Bevacizumab or Ranibizumab was widely used as therapy for macular edema (ME) in retinal vein occlusion (RVO) and diabetic retinopathy. The purpose of this study was to comparing short-term outcomes for patients who received intravitreal Bevacizumab (IVB) injection or Ranibizumab (IVR) for ME due to RVO
Methods: This was observational, cross sectional study comparing patients received IVB or IVR. Primary outcomes data (visual acuity and central macular thickness/CMT) and secondary outcomes data (number injection and intra ocular pressure/IOP) were collected at baseline and 3 months after injection
Results: There were 4 eyes in each group. There were no significant difference in mean change of visual acuity (-0.2750.25 vs -0.150.5 logMAR; p=0.676) and CMT (-171.50 129.08 vs -98.2537.67 m; p=0.345) in IVB vs IVR groups. There were also no significant difference in mean change of IOP (22.16 vs 24.69 mmHg; p=1) and number of injection (2.250.50 vs 1.750.9; p=0.401 ) in both groups.
Conclusion: In short-term both IVB and IVB have relative similar outcomes on increasing visual acuity and decreasing CMT in ME due to RVO
PENGARUH BAURAN PEMASARAN TERHADAP MINAT MASYARAKAT DALAM PENGAJUAN KREDIT KEPEMILIKAN RUMAH (KPR) DI BANK TABUNGAN NEGARA (BTN) KC PEMANTANG SIANTAR
Authors: Saragih Elima , Fania Bona , Sekali Karolus Karo , Marpaung Fenny Krisna , Meliza Juli 
Published: November 2024

ABSTRAK
Tujuan dari penelitian ini adalah untuk menilai sejauh mana minat masyarakat dalam memperoleh kredit pemilikan rumah (KPR) di Bank Tabungan Negara (BTN) KC Pematang Siantar, melalui penerapan bauran pemasaran yang terdiri dari empat komponen: produk, harga, tempat, promosi. Penelitian ini menggunakan metodologi deskriptif kuantitatif untuk mengetahui pengaruh minat masyarakat terhadap bauran pemasaran ketika mengajukan kredit kepemilikan rumah di BTN KC Pematang Siantar. Data dikumpulkan melalui wawancara ekstensif yang dilakukan dengan perwakilan dan nasabah bank BTN.
Kata Kunci: produk,harga,tempat,promosi

ABSTRACT
The aim of this study is to assess the extent of public interest in acquiring home Ownership credit (KPR) at Bank Tabungan Negara (BTN) KC Pematang Siantar, Via the implementation of a marketing mix consisting of four components: product, price, location, and promotion.This study utilises a quantitative descriptive Methodology to determine the influence of public interest on the marketingmix When applying for home ownership credit at BTN KC Pematang Siantar.The data Was collected via extensive interviews performed with representatives and Customers of BTN bank.

Keywords:product,price,place,promotion
PENGARUH UKURAN KAP, UKURAN PERUSAHAAN, OPINI AUDIT, DAN PROFITABILITAS TERHADAP AUDIT DELAY PADA PERUSAHAN MAKANAN DAN MINUMAN YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2020-2023
Authors: Simamora Christinawati Fiola , Pratama Ayang , Lubis Yeti Meliany 
Published: November 2024

Penelitian ini bertujuan untuk menguji pengaruh Ukuran KAP, Ukuran Perusahaan, Opini Audit dan Profitabilitas berpengaruh terhadap Audit Delay pada perusahaan Makanan dan Minuman yang terdaftar di Bursa Efek Indonesia Periode 2020-2023. Pengambilan sampel pada penelitian ini menggunakan teknik purposive sampling dengan jumlah sampel sebanyak 20 perusahaan. Metode analisis yang digunakan pada penelitian ini yaitu statistik deskriptif, uji asumsi klasik meliputi uji normalitas, uji multikoliniearitas, uji autokorelasi, uji heteroskedastisitas, dan uji hipotesis meliputi analisis regresi linier berganda, koefisien determinasi, uji f dan uji t. Dalam pengujian hipotesis pada penelitian ini, terdapat hasil secara parsial dan simultan. Hasil secara parsial menunjukan bahwa variable ukuran KAP berpengaruh signifikan terhadap audit delay, dan ukuran perusahaan, opini audit, profitabilitas tidak berpengaruh terhadap audit delay. Sedangkan hasil secara simultan menunjukan bahwa variable yaitu secara simultan Ukuran KAP, Ukuran Perusahaan, Opini Audit dan Profitabilitas berpengaruh terhadap Audit Delay pada perusahaan Makanan dan Minuman yang terdaftar di Bursa Efek Indonesia Periode 2020-2023.
Kata Kunci : Ukuran KAP, Ukuran Perusahaan, Opini Audit, Profitabilitas, Audit Delay

ABSTRACT
This research aims to examine the influence of KAP Size, Company Size, Audit Opinion and Profitability on Audit Delay in Food and Beverage companies listed on the Indonesia Stock Exchange for the 2020-2023 period. Sampling in this study used a purposive sampling technique with a total sample of 20 companies. The analytical methods used in this research are descriptive statistics, classical assumption tests including normality tests, multicollinearity tests, autocorrelation tests, heteroscedasticity tests, and hypothesis tests including multiple linear regression analysis, coefficient of determination, f test and t test. In testing the hypothesis in this research, there were partial and simultaneous results. Partial results show that the KAP size variable has a significant effect on audit delay, and company size, audit opinion, profitability have no effect on audit delay. Meanwhile, the results simultaneously show that the variables, namely KAP Size, Company Size, Audit Opinion and Profitability, simultaneously influence Audit Delay in Food and Beverage companies listed on the Indonesia Stock Exchange for the 2020-2023 period.
Keywords: KAP size, company size, audit opinion, profitability, audit delay
Uji aktivitas antioksidan ekstrak etanol daun benalu Helixanthera cylindrica (Jack) Danser pada tumbuhan kelor (Moringa oleifera) dengan metode 2,2-diphenyl-1-picrylhydrazyl
Authors: Potalangi Nerni Olvi , Palandi Reky Royke , Manoppo Amalia J. , Tewu Tewsi M. , Kanter Jabes Wolter , Sambou Christel Nataniel 
Published: November 2024

Radikal bebas dapat berasal dari dalam tubuh manusia hasil proses metabolisme dari reaksi kimia dalam tubuh dan radikal bebas dari luar tubuh atau lingkungan diantaranya berasal dari asap kendaraan bermotor, polusi udara oleh pabrik, bahan kimia industri, bahan makan dan minuman, asap rokok, radiasi dan sinar matahari. Antioksidan merupakan komponen yang dapat mencegah sel atau molekul teroksidasi dengan cara mendonorkan electron atau atom hydrogen pada radikal bebas. Dampak reaktivitas senyawa radikal bebas dapat berupa kerusakan sel atau jaringan, penyakit degeneratif hingga penyakit kanker. Salah satu benalu pada tumbuhan kelor yakni Helixanthera cylindrica (Jack) Danser memiliki kandungan senyawa metabolit sekunder antara lain alkaloid, flavonoid dan saponin. Tujuan penelitian ini untuk mengetahui apakah daun benalu Helixanthera cylindrica (Jack) Danser memiliki aktivitas sebagai antioksidan menggunakan metode 2,2-Diphenyl-1-Picrylhydrazyl (DPPH). Metode penelitian yakni eksperimental laboratorium dengan 5 konsentrasi 3 kali ulangan, selanjutnya pengujian aktivitas antioksidan dilakukan secara kualitatif dengan menggunakan metode DPPH pada panjang gelombang 517 nm dan menggunakan Spektrofotometer UV-Vis. Berdasarkan hasil penelitian uji antioksidan ekstrak daun benalu Helixanthera cylindrica (Jack) Danser memiliki aktivitas yang sangat kuat dengan nilai IC50 28.74 ppm sedangkan pembanding vitamin C memiliki nilia IC50 1.57 ppm, dengan nilai persamaan regresi dari konsentrasi benalu y=0.3344x + 40.389 dengan nilai R2=0.9726 dan vitamin C menunjukkan y=4.4065x + 43.079 dengan nilai R2=0.9677. maka dapat disimpulkan bahwa daun benalu Helixanthera cylindrica (Jack) Danser pada tumbuhan kelor (Moringa oliefera) memiliki aktivitas antioksidan yang sangat kuat.
Elevation and Slope as Key Determinants of Landslide-Prone Areas in Murang’a County, Kenya
Authors: Maina Njiraini John 
Published: November 2024

Landslide studies in Kenya have received less interest as opposed to other regions of the world. Murang’a County in Central Kenya presents a unique case of geographical interest not only due to its positioning within the alpine Aberdare Ranges but also because it has experienced serious, deadly and repeated landslide disasters. This study seeks to ascertain whether elevation and slope are key determinants of landslide in the county. Primary data collection instruments were Household (HH) questionnaires where a sample size of 393 HH was sampled at a confidence level of 95%. Secondary data for elevation and slope were derived from satellite imagery. A significant 95.5% of the respondents said that slope was a major landslide causal/trigger factor. A significant number of people (r=0.806) who had migrated to their current locations described steepness as a major causal/trigger factor. Elevation factor was mentioned by 90.2% of the respondents as a key factor contributing to the occurrence of landslides. The study concludes that elevation and slope are key and significant landslide causal/trigger factors in Murang’a County. The study recommends that people living in areas delineated as ‘high-risk zones’ should be advised to relocate to safer grounds to avert huge losses from potential landslide disasters
Searching for GEMS: Characterizing Six Giant Planets Around Cool Dwarfs
Authors: Kanodia Shubham , Gupta Arvind F. , Cañas Caleb I. , Bernabò Lia Marta , Reji Varghese , Han Te , Brady Madison , Seifahrt Andreas , Cochran William D. , Morrell Nidia , Basant Ritvik , Bean Jacob , Bender Chad F. , de Beurs Zoë L. , Bieryla Allyson , Birkholz Alexina , Brown Nina , Chapman Franklin , Ciardi David R. , Clark Catherine A. , Cotter Ethan G. , Diddams Scott A. , Halverson Samuel , Hawley Suzanne , Hebb Leslie , Holcomb Rae , Howell Steve B. , Kobulnicky Henry A. , Kowalski Adam F. , Larsen Alexander , Libby-Roberts Jessica , Lin Andrea S. J. , Lund Michael B. , Luque Rafael , Monson Andrew , Ninan Joe P. , Parker Brock A. , Patel Nishka , Rodruck Michael , Ross Gabrielle , Roy Arpita , Schwab Christian , Stefánsson Guđmundur , Thoms Aubrie , Vanderburg Andrew 
Published: November 2024

Abstract
Transiting giant exoplanets around M-dwarf stars (GEMS) are rare, owing to the low-mass host stars. However, the all-sky coverage of TESS has enabled the detection of an increasingly large number of them to enable statistical surveys like the Searching for GEMS survey. As part of this endeavor, we describe the observations of six transiting giant planets, which include precise mass measurements for two GEMS (K2-419Ab, TOI-6034b) and statistical validation for four systems, which includes validation and mass upper limits for three of them (TOI-5218b, TOI-5616b, TOI-5634Ab), while the fourth one—TOI-5414b is classified as a “likely planet.” Our observations include radial velocities from the Habitable-zone Planet Finder on the Hobby–Eberly Telescope, and MAROON-X on Gemini-North, along with photometry and high-contrast imaging from multiple ground-based facilities. In addition to TESS photometry, K2-419Ab was also observed and statistically validated as part of the K2 mission in Campaigns 5 and 18, which provide precise orbital and planetary constraints despite the faint host star and long orbital period of ∼20.4 days. With an equilibrium temperature of only 380 K, K2-419Ab is one of the coolest known well-characterized transiting planets. TOI-6034 has a late F-type companion about 40″ away, making it the first GEMS host star to have an earlier main-sequence binary companion. These confirmations add to the existing small sample of confirmed transiting GEMS.
Forecasting Constraints from Surface Brightness Fluctuations in Galaxy Clusters
Authors: Romero Charles E. 
Published: November 2024

Abstract
Studies of surface brightness (SB) fluctuations in the intracluster medium present an indirect estimate of turbulent pressure support and associated Mach numbers. While high-resolution X-ray spectroscopy can directly constrain line-of-sight gas motions, including those due to turbulence, such observations are relatively expensive and will be limited to nearby, bright clusters. In this respect, SB fluctuations are the most economical means to constrain turbulent motions at large cluster radii across a range of redshifts and masses. To forecast what current and future X-ray and Sunyaev–Zel’dovich facilities may achieve in SB fluctuation studies, I review and synthesize matters of accuracy and precision with respect to calculating power spectra of SB fluctuations, from which turbulent properties are derived. Balancing concerns of power spectrum accuracy and precision across a range of spatial scales, I propose the use of three annuli with [0, 0.4]R
500, [0.4, 1]R
500, and [1, 1.5]R
500. Adopting these three regions, I calculate the uncertainty in the hydrostatic mass bias,

σ

b

M

, that can be achieved for various instruments in several scenarios. I find that Lynx and AtLAST are competitive in their constraints at R
500, while AtLAST should perform better when constraining

σ

b

M

at R
200.
No Redshift Evolution in the Fe ii/Mg ii Flux Ratios of Quasars across Cosmic Time
Authors: Jiang Danyang , Onoue Masafusa , Jiang Linhua , Lai Samuel , Bañados Eduardo , Becker George D. , Bischetti Manuela , Bosman Sarah E. I. , Davies Rebecca L. , D’Odorico Valentina , Farina Emanuele Paolo , Haehnelt Martin G. , Mazzucchelli Chiara , Schindler Jan-Torge , Walter Fabian , Zhu Yongda 
Published: November 2024

Abstract
The Fe ii/Mg ii emission line flux ratio in quasar spectra serves as a proxy for the relative Fe to α-element abundances in the broad-line regions of quasars. Due to the expected different enrichment timescales of the two elements, they can be used as a cosmic clock in the early Universe. We present a study of the Fe ii/Mg ii ratios in a sample of luminous quasars exploiting high-quality near-IR spectra taken primarily by the XQR-30 program with VLT XSHOOTER. These quasars have a median bolometric luminosity of log(L
bol[erg s−1]) ∼ 47.3 and cover a redshift range of z = 6.0–6.6. The median value of the measured Fe ii/Mg ii ratios is ∼7.9 with a normalized median absolute deviation of ∼2.2. In order to trace the cosmic evolution of Fe ii/Mg ii in an unbiased manner, we select two comparison samples of quasars with similar luminosities and high-quality spectra from the literature, one at intermediate redshifts (z = 3.5–4.8) and the other at low redshifts (z = 1.0–2.0). We perform the same spectral analysis for all these quasars, including the usage of the same iron template, the same spectral fitting method, and the same wavelength fitting windows. We find no significant redshift evolution in the Fe ii/Mg ii ratio over the wide redshift range from z = 1 to 6.6. The result is consistent with previous studies and supports the scenario of a rapid iron enrichment in the vicinity of accreting supermassive black holes at high redshift.
AI-Driven Education, Careers, and Entrepreneurship for a Transformed Tomorrow
Authors: Burton Sharon L , O'Neal Derrick 
Published: November 2024

In this in-depth exploratory case study of artificial intelligence (AI), the researchers applied a scaled, reactive, and parallel approach relating to education, employment, and entrepreneurship, wherein the data from the previous case study was used to inform the next of three case studies. Dissimilar to what was supposed from extant literature, the results revealed that AI may support learning without escalating biases or inequities. Increased and continued learning occurred within two weeks of the first pilot.The findings contribute to the resourcing literature by unveiling the capability to apply AI-driven data to boost an increase in behavioral learning, whether classical, operant, or observational. Specifically, the data shows that underperforming students, those lagging on standardized tests, and those of lower income levels can increase their learning when offered individualized and adaptive learning tailored to distinct needs, preferences, and abilities. The change is due to increased purposive attention that is AI-driven and maintains learners' interests through an avatar. This study shows how AI progress, particularly scaled, reactive, and parallel AI, can lead to new tools and services for advancements that impact performance support, employment trends, corporate learning, and professional development. Also, the study shows that AI-driven education can improve job prospects and career growth, benefiting learners, academics, and practitioners. This exploratory research results inform widespread AI implementation, fostering educational and career synergies.
Retour sur l’archéologie mortuaire d’époque médiévale dans le sud-ouest du Nigéria
Authors: Chapelain de Seréville-Niel Cécile , Chouin Gérard , Ogunfolakan Adisa 
Published: November 2024

Dans quelle mesure les os humains identifiés en fouilles depuis les années 1960 dans deux centres urbains majeurs du Nigéria médiéval pourraient-ils témoigner – ou pas – du passage, dans la seconde moitié du xive siècle, de la pandémie de peste ? Notre réflexion s’appuie sur l’analyse des ossements d’individus retrouvés dans une fosse commune à Benin City en 1962-1963, des restes très partiels d’un enfant mis au jour sur le site d’Oduduwa College II, à Ile-Ife en 2019, et sur des descriptions de restes humains découverts lors de différents projets archéologiques dans cette cité centrale du monde yoruba. La position stratigraphique des squelettes, la disposition des corps, les marques observées sur certains os sont autant d’éléments qu’il nous faut prendre en compte pour nourrir notre réflexion sur la peste et plus largement sur les pratiques mortuaires en Afrique tropicale avant l’ouverture du commerce atlantique, et leurs conséquences sur les dépôts archéologiques.
Evaluation of stevia leaf (<em>Stevia rebaudiana</em> Bertoni) powder as sugar-substitute in cashew nut fortified cookies
Authors: Dilrukshi H. M. W. , Ulpathakumbura B. S. K. , Gunarathna K. M. R. U. , Iqbal M. C. M. , Lai O. M. , Marikkar J. M. N. 
Published: November 2024

Stevia rebaudiana is an herbal supplement used as a substitute for sugar in food processing. Considering the potentials of stevia as a zero-calorie-natural sweetener, this study aimed to assess the antioxidant and anti-hyperglycemic properties of stevia (Stevia rebaudiana Bertoni) leaf powder (SLP) to find its suitability to formulate low-calorie foods. Extracts of SLP obtained with hexane, ethyl acetate, and methanol were evaluated for DPPH, ABTS+, FRAP and enzyme inhibitory assays. Adopting a standard recipe, five different cookie types were prepared by incorporating varying proportions of SLP and evaluated by a 30 semi-trained panel. The nutritional composition and shelf-life stability were also evaluated. SLP had moisture (8.0 %), ash (13.5 %), crude protein (12.4 %), crude fat (6.9 %), crude fiber (18.3 %), and carbohydrate (40.9 %). Sensory results showed that the cookie formulated with the lowest amount of SLP (T1= 2.0g) had the highest overall acceptability with the highest preference for appearance and smell. The cookie type formulated with the highest amount of SLP (T4= 8.0g) had the highest crude protein (13.50%), crude fiber (21.76%), and lowest carbohydrate contents (40.88%). The keeping quality of the cookies remained acceptable within the storage period. These results suggest that acceptable quality cashew nut fortified cookies could be prepared by replacing sucrose with stevia leaf powder
Necrotizing Fasciitis in a Lactating Breast: A Case Report and Literature Review
Authors: Janjua Nusrat Batool , Mohammedelfateh Adam , Vanapalli Manju Rao , Mc Cabe Mark , Bulfin Claire , Stratton John 
Published: November 2024

Abstract

Introduction:
Necrotizing fasciitis (NF) is a serious, rapidly progressive disease with significant maternal morbidity and mortality. This case report highlights the rare occurrence of NF in a lactating breast.

Patient concerns:
A 3-week postnatal young patient exclusively breastfeeding developed left breast engorgement and pain and received two courses of antibiotics for left mastitis. At 6 weeks postnatal, she presented to the hospital with a left breast abscess and fever.

Diagnosis:
Inflammatory markers were raised. Ultrasound confirmed the presence of a breast abscess.

Intervention:
The patient was started on antibiotics, and ultrasound-guided aspiration was performed. However, the skin turned black with a rapidly spreading infection; subsequently, she had a debridement of necrotic breast tissue and a biopsy in the theater. Histology confirmed a diagnosis of NF.

Outcome:
A wound dressing with negative pressure wound therapy was applied. The patient was prescribed Cabergoline 0.25 mg every 12 hours for 2 days to stop milk production. She responded well to an autologous skin graft by the breast team and was discharged.

Conclusion:
The report emphasizes the importance of considering NF as a potential diagnosis in cases of infection in a lactating breast unresponsive to conventional treatment. Early diagnosis and prompt treatment with antibiotics, surgical debridement, and multidisciplinary care are prudent to prevent adverse sequelae, such as sepsis, partial/total mastectomy, and psychological distress. A biopsy is mandatory to exclude coexistent malignancy.