bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum anti-Müllerian hormone levels in women with rheumatoid arthritis during tumor necrosis factor-α inhibitor treatment: Exploratory research
Authors: Isojima Sakiko , Miura Yoko , Saito Mayu , Yajima Nobuyuki , Miwa Yusuke , Kasama Tsuyoshi 
Published: January 2019

Background We evaluated serum anti-Müllerian hormone in women with rheumatoid arthritis newly introduced to tumor necrosis factor-α inhibitor treatment for 54 weeks to investigate the treatment’s effect on ovarian reserve. Methods A total of 12 premenopausal women with rheumatoid arthritis aged 20–50 years were recruited at our division, who had been newly treated with tumor necrosis factor-α inhibitor (infliximab or etanercept) from 1 April 2008 to 31 March 2014. Serial serum anti-Müllerian hormone levels and disease activity scores (DAS28-CRP) were examined at defined periods: start of treatment and 14, 30, and 54 weeks after start of treatment. Results DAS28-CRP scores in 12 women were significantly decreased from a mean of 4.6 (±SD: 0.4) to 2.3 (±0.4) after 54 weeks of treatment ( p < 0.001). Serum anti-Müllerian hormone levels and its z scores did not change significantly. Conclusion Treatment with a tumor necrosis factor-α inhibitor did not affect serum anti-Müllerian hormone levels in 12 women with rheumatoid arthritis during 54-week treatment.
Predictors of In-Hospital Ambulatory Status Following Low-Energy Hip Fracture Surgery
Authors: Villa Jordan C. , Koressel Joseph , van der List Jelle P. , Cohn Matthew , Wellman David S. , Lorich Dean G. , Lane Joseph M. 
Published: January 2019

Introduction: Twenty-five percent to seventy-five percent of independent patients do not walk independently after hip fracture (HF), and many patients experience functional loss. Early rehabilitation of functional status is associated with better long-term outcomes; however, predictors of early ambulation after HF have not been well described. Purposes: To assess the impact of perioperative and patient-specific variables on in-hospital ambulatory status following low-energy HF surgery. Methods: This is a retrospective analysis of 463 geriatric patients who required HF surgery at a metropolitan level-1 trauma center. The outcomes were time to transfer (out of bed to chair) and time to walk. Results: Three hundred ninety-two (84.7%) patients were able to transfer after surgery with a median time of 43.8 hours (quartile range: 24.7-53.69 hours), while 244 (52.7%) patients were able to walk with a median time of 50.86 hours (quartile range: 40.72-74.56 hours). Preinjury ambulators with aids (hazard ratio [HR]: 0.70, confidence interval [CI]: 0.50-0.99), age >80 years (HR: 0.66, CI: 0.52-0.84), peptic ulcer disease (HR: 0.57, CI: 0.57-0.82), depression (HR: 0.66, CI: 0.49- 0.89), time to surgery >24 hours (HR: 0.77, CI: 0.61-0.98), and surgery on Friday (HR: 0.73, CI: 0.56-0.95) were associated with delayed time to transfer. Delayed time to walk was observed in patients over 80 years old (HR: 0.74, CI: 0.56-0.98), females (HR: 0.67, CI: 0.48-0.94), peptic ulcer disease (HR: 0.23, CI: 0.84-0.66), and depression (HR: 0.51, CI: 0.33-0.77). Conclusions: Operative predictors of delayed time to transfer were surgery on Friday and time to surgery >24 hours after admission. Depression is associated with delayed time to transfer and time to walk. These data suggest that is important to perform surgeries within 24 hours of admission identify deficiencies in care during the weekends, and create rehabilitation programs specific for patient with depression. Improving functional rehabilitation after surgery may facilitate faster patient discharge, decrease inpatient care costs, and better long-term functional outcomes.
Late HIV Diagnosis but Earlier Antiretroviral Treatment Initiation in Northwest Spain: Impact of Current Treatment Guidelines
Authors: Cid-Silva Purificación , Margusino-Framiñán Luis , Balboa-Barreiro Vanesa , Pernas-Souto Berta , Mena-De-Cea Álvaro , Martín-Herranz Isabel , Castro-Iglesias Ángeles , Poveda Eva 
Published: January 2019

Background: Current HIV treatment guidelines recommend antiretroviral treatment (ART) initiation for all HIV-infected individuals regardless of CD4 count. This study evaluates the immunological and virological status and the clinical characteristics of patients who have started ART in the last 8 years in the Northwest of Spain. Methods: All HIV-infected patients who have started ART between January 2009 and December 2016 at a reference hospital in the Northwest of Spain were included in this retrospective observational study. Epidemiological, clinical, and immunovirological features and antiretroviral drugs used for initiation were recorded. A statistical analysis was performed using SPSS version 19 software. Categorical and continuous variables were compared by the specific statistical tests, and a logistic regression model was used to identify time associated with Center for Disease Control and Prevention (CDC) categories change. Results: A high proportion of HIV-infected patients (66.7%) had initiated ART with CD4 counts <350 cells/mm3 in the last 8 years. From these, most of them (68.3%) had <350 CD4 counts at first contact with HIV specialist medical team, 12.2% had no indications for ART initiation in the last clinic visit before ART initiation according to the national guidelines at that moment, 11.0% were lost to follow-up because of lack of compliance with scheduled visits and 8.5% of patients refused treatment. A logistic regression model showed that a delay of one month since the first contact with HIV specialist medical team to ART initiation involves a risk of worsening in the CDC clinical category (odds ratio: 1.02 [95% confidence interval: 1.012-1.029]; P < .001). A trend towards an earlier start of ART was observed during 2015 and 2016, likely influenced by the last treatment guidelines recommendations. Conclusion: High proportion of HIV-infected patients (66.7%) had initiated ART with CD4 counts <350 cells/mm3 in the last 8 years. The main reasons for this problem were analyzed and an important rate of late diagnosis was identified. However, a trend towards an earlier start of ART was observed during 2015 and 2016, likely influenced by the last treatment guidelines recommendations. These findings highlight the need to promote and facilitate HIV testing to reduce the late diagnosis as well as counseling on HIV prevention, treatment, and linkage care.
Superior silybin bioavailability of silybin–phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers*
Authors: Méndez-Sánchez Nahum , Dibildox-Martinez Miguel , Sosa-Noguera Jahir , Sánchez-Medal Ramón , Flores-Murrieta Francisco J. 
Published: January 2019

Abstract
Background
Fibrosis is a response to chronic liver disease that results in excessive accumulation of extracellular matrix proteins and formation of scar tissue. Fibrosis represents a clinical challenge of worldwide significance. Several studies have demonstrated that many natural products and herbal medicines have activity against liver fibrosis, and extracts of milk thistle such as silymarin and silybin are the natural compounds most commonly prescribed for liver diseases. Therefore, we sought to assess and compare the pharmacokinetic properties and bioavailability of silybin–phosphatidylcholine complex in oily-medium soft-gel capsules and conventional silymarin tablets in healthy Mexican volunteers.

Methods
We enrolled 23 healthy volunteers to participate in a prospective, balanced, blind, single-dose, two-way crossover study with a one-week washout period. Fasting participants received either 45 mg silybin–phosphatidylcholine complex or 70 mg silymarin to assess which formulation provided better bioavailability of silybin. Plasma was obtained and analysed for silybin concentration using a validated ultra-performance liquid chromatography–tandem mass spectroscopy method. Pharmacokinetic parameters were obtained by non-compartmental analysis and values were compared by analysis of variance for a crossover design. Ratios of maximum plasma drug concentration and area under the curve (AUC) were obtained and 90% confidence intervals were calculated.

Results
The 23 healthy subjects (11 women, 12 men) who participated in the study were aged 22–31 years old (average: 28), average weight 64.8 kg, height 1.65 m and body mass index 23.5 kg/m2. Plasma levels of silybin were higher after the administration of silybin–phosphatidylcholine complex capsules compared with that after conventional silymarin tablets (P <  0.0001).

Conclusions
The silybin–phosphatidylcholine complex in oily-medium soft-gel capsules seems to provide superior bioavailability. However, clinical studies must be performed to demonstrate its clinical relevance in the treatment of liver diseases.

Trial registration
NCT03440164; registered on November 11, 2016.
Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility
Authors: Giordano Tiziana , Gadadhar Sudarshan , Bodakuntla Satish , Straub Jonas , Leboucher Sophie , Martinez Guillaume , Chemlali Walid , Bosc Christophe , Andrieux Annie , Bieche Ivan , Arnoult Christophe , Geimer Stefan , Janke Carsten 
Published: January 2019

ABSTRACT
Sperm cells are highly specialized mammalian cells, and their biogenesis requires unique intracellular structures. Perturbation of spermatogenesis often leads to male infertility. Here, we assess the role of a post-translational modification of tubulin, glutamylation, in spermatogenesis. We show that mice lacking the tubulin deglutamylase CCP5 (also known as AGBL5) do not form functional sperm. In these mice, spermatids accumulate polyglutamylated tubulin, accompanied by the occurrence of disorganized microtubule arrays, in particular in the sperm manchette. Spermatids further fail to re-arrange their intracellular space and accumulate organelles and cytosol, while nuclei condense normally. Strikingly, spermatids lacking CCP5 show supernumerary centrioles, suggesting that glutamylation could control centriole duplication. We show that most of these observed defects are also present in mice in which CCP5 is deleted only in the male germ line, strongly suggesting that they are germ-cell autonomous. Our findings reveal that polyglutamylation is, beyond its known importance for sperm flagella, an essential regulator of several microtubule-based functions during spermatogenesis. This makes enzymes involved in glutamylation prime candidates for being genes involved in male sterility.
Amino Amide Organocatalysts for Asymmetric Michael Addition of β-Keto Esters with β-Nitroolefins
Authors: Owolabi Isiaka Alade , Chennapuram Madhu , Seki Chigusa , Okuyama Yuko , Kwon Eunsang , Uwai Koji , Tokiwa Michio , Takeshita Mitsuhiro , Nakano Hiroto 
Published: January 2019

Abstract
Asymmetric Michael addition of β-keto esters with trans-β-nitroolefins using chiral amino amide organocatalyst was tried and afforded synthetically useful chiral Michael adducts in both excellent chemical yields (up to 99%) and stereoselectivities (up to dr. 99:1, up to 98% ee).
EEG correlation at a distance: A re-analysis of two studies using a machine learning approach
Authors: Bilucaglia Marco , Pederzoli Luciano , Giroldini William , Prati Elena , Tressoldi Patrizio 
Published: January 2019

Background: In this paper, data from two studies relative to the relationship between the electroencephalogram (EEG) activities of two isolated and physically separated subjects were re-analyzed using machine-learning algorithms. The first dataset comprises the data of 25 pairs of participants where one member of each pair was stimulated with a visual and an auditory 500 Hz signals of 1 second duration. The second dataset consisted of the data of 20 pairs of participants where one member of each pair received visual and auditory stimulation lasting 1 second duration with on-off modulation at 10, 12, and 14 Hz. Methods and Results: Applying a ‘linear discriminant classifier’ to the first dataset, it was possible to correctly classify 50.74% of the EEG activity of non-stimulated participants, correlated to the remote sensorial stimulation of the distant partner. In the second dataset, the percentage of correctly classified EEG activity in the non-stimulated partners was 51.17%, 50.45% and 51.91%, respectively, for the 10, 12, and 14 Hz stimulations, with respect the condition of no stimulation in the distant partner. Conclusions: The analysis of EEG activity using machine-learning algorithms has produced advances in the study of the connection between the EEG activities of the stimulated partner and the isolated distant partner, opening new insight into the possibility to devise practical application for non-conventional “mental telecommunications” between physically and sensorially separated participants.
GOLD PROVENANCE AND CHARACTERIZATION USING MICRO X-RAY FLUORESCENCE (µXRF): PRELIMINARY RESULTS/ PROVENIÊNCIA E CARACTERIZAÇÃO DE OURO COM MICRO FLUORESCÊNCIA DE RAIOS X (μXRF): RESULTADOS PRELIMINARES
Authors: Canto William Murussi , Gama Filho Hamilton Santos , José dos Anjos Marcelino , Tavares Jr. Armando Dias , Geraldes Mauro César 
Published: January 2019

This work presents some preliminary results that allows to characterize gold samples using Micro X-Ray Fluorescence/µXRF. The first aim of this work is to apply a noninvasive technique, preserving the sample integrity, in order to identify the composition of gold samples and to recognize their possible geographical provenance. Samples have been obtained in geographically distinct gold-digging sites, in three Brazilian and one Colombian areas. These samples were processed only by fusion into a furnace at 1,200 ºC. The proportion of Au, Ag and Cu were measured in gold samples. The results of this work, allowed to characterize and to identify quite well the pure gold provenance, using µXRF instrumentation and related techniques. Further work is in progress to determine the behavior of mixed gold samples from different provenances. Besides that, measurements with different sample preparation will be made, in order to compare the results obtained in this work with those obtained by LA-ICP-MS techniques. ResumoEste trabalho apresenta resultados preliminares que permitem caracterizar amostras de ouro utilizando a Micro Fluorescência de Raios-X/ µXRF. O primeiro objetivo deste trabalho é aplicar uma técnica não invasiva, preservando a integridade da amostra, para identificar a composição de amostras de ouro e reconhecer a sua possível proveniência geográfica. As amostras foram obtidas em locais de exploração de ouro geograficamente distintos, em três áreas brasileiras e uma colombiana. Estas amostras foram sugeitas a fusão a 1.200 ºC, num forno. A proporção de Au, Ag e Cu foi medida em amostras de ouro. Os resultados deste trabalho permitiram caracterizar e claramente identificar a proveniência de ouro puro, utilizando resultados de µXRF. Estão em andamento outros trabalhos para determinar o comportamento da mistura de amostras de ouro de diferentes procedências. Além disso, serão efetuadas medições com diferentes preparações de amostras, a fim de comparar os resultados obtidos neste trabalho com os que estão sendo aquiridos com técnicas de LA-ICP-MS.
DEL PRECEDENTE JUDICIAL A LOS PRECEDENTES OBLIGATORIOS: ¿VENTAJA O AMENAZA PARA LOS TRIBUNALES INFERIORES?
Authors: Martín Nuria Belloso 
Published: January 2019

Las teorías de la argumentación jurídica, la globalización en el ámbito jurídico y el afianzamiento de las jurisdicciones constitucionales han impulsado en nuestros días la progresiva centralidad de la jurisprudencia, gracias al rol protagónico reconocido a la función judicial. La jurisprudencia, los precedentes judiciales y la doctrina legal son conceptos que aunque estén ellos conceptos estrechamente relacionados, no significan lo mismo ni conllevan el mismo grado de vinculación para el juzgador. Si a esto añadimos la confusión que se produce por el hecho de utilizar en el sistema continental conceptos a los que damos el significado que tiene en el sistema anglosajón, la situación de confusión se incrementa. En este trabajo prestaremos especial atención a la doctrina del precedente judicial. Se analizará la aproximación del civil law al common law, la distinción entre precedente, jurisprudencia y doctrina legal. Se examinará la doctrina de los precedentes en diversos contextos tales como en el Tribunal Constitucional español, en México y en Brasil, prestando especial atención a la universalidad de los precedentes y a los precedentes obligatorios, lo que lleva a cuestionarse si no se estará invadiendo la independencia del juzgador.
The Correction of The Auricle in Neurofibroma with Aggressive Tumor Removal Principle and Two Stages Total Ear Reconstruction
Authors: Bangun Kristaninta , Chen Zung Chung 
Published: January 2019

Background: Neurofibroma is a major facial hamartoma and is one of the most destructive and debilitating disease affecting the skin, muscle, mucosa, and the skeletal systems. Involvement of the ear usually increases the dimensions of the auricular skin and underlying tissues, distorts normal architecture along with auricular malpositioning, producing an ear that is abnormal in size, shape and position. The correction of the auricle in neurofibroma and benign tumors of the head and neck has been reported, but overall favorable results appear difficult to attain. We present a case of neurofibroma of the auricle in which radical resection was performed, and reconstruction was done in a two-stage surgery with satisfactory result. Patient and Methods: A 30 years-old female presented with type-1 neurofibroma to our office, especially concerned of a large tumor growth on the right auricle. With prior experience in treating microtia cases by Nagata’s method, we performed a two-stage operation on the patient. The first operation involved excising the whole auricular mass, and fabricating as well as grafting of a three-dimensional costal cartilage framework. In the second stage, the ear was elevated.Result: Nine months after the second surgery, the result was satisfactory with good auricular definition attained, and proper elevation of the ear at the correct anatomical site. No sign of neurofibroma recurrence was found on the surrounding reconstructed auricle.Summary: In our experience, the correction Neurofibroma of the ear by using the aggressive tumor removal principle combined with Nagata’s two-stage total ear reconstruction delivered a satisfactory result.
Management and Treatment of Gynecomastia with Liposuction
Authors: Sari Tessa Puspita , Sudjatmiko Gentur 
Published: January 2019

Background: Gynecomastia is a common problem of the male breast, with a reported overall incidence of 32 to 36 percent. The surgical management of gynecomastia has undergone significant changes over the past few decades, from a predominantly open approach to one involving liposuction only or liposuction combined with direct excision through a periareolar or remote incision. Patients and Method: We present five cases with bilateral gynecomastia. One patient is a teenager and others are adult males. Liposuction only was performed in patients without palpable glandular breast mass. Direct excision was made to help remove the excessive glandular breast mass. The compressive garment is worn for 4 to 6 weeks after procedure to prevent the complications of the surgical procedure.Result: Three of the patients are corrected with liposuction only. There are two patients who underwent combination of open excision and liposuction. The liposuction procedure only left minimal scar from canulas incision. Other patient has minimal periareolar incision to remove excess breast tissue. None of the patients showed complication after surgery.Summary: All of the patients presented were satisfied by the correction of gynecomastia using liposuction. None of the patients shows any complication after liposuction procedure. The result after surgery is a natural-looking chest without extensive scar. The patients appreciate the early return to work and normal physical activities.
Pectoralis Major Musculocutaneous Flap and Splitthickness Skin Graft for The Reconstruction of Pharyngocutaneous Fistula After Total Laryngeal Resection
Authors: Atmodiwirjo Parintosa , Pribadi Sweety 
Published: January 2019

Background: Pharyngocutaneous fistula (PCF) is the most frequent complication in the early postoperative period after total laryngectomy. Most PCF respond well to conservative management, but when it fails and the fistula persists surgical closure in indicated. Patients and Methods: Sixty-five year-old male was consulted to our division following total laryngectomy by the Ear Nose Throat surgeons, with wound dehiscence and pharyngocutaneous fistula. We performed a pectoralis major musculocutaneous flap (PMMCF) to close the fistula after a failed conservative management. The skin island of PMMCF was used as an inner lining to close the laryngeal fistula, the exteriorized muscle part of the "ap was then covered by skin graft.Results: PMMCF is a technically simple and reliable distant musculocutaneous pedicled flap to cover defect on the neck area. The skin island of the flap provided an adequate air-thight cover and successfully closed the laryngeal fistula.Summary: PCF is a problematic complication resulting from the resection of head and neck tumor. Early diagnosis and proper multidisciplinary management is required to prevent further morbidity. PMMCF is a simple, easy to perform and reliable option for closure of PCF.
Computer Simulation Aided Study of a Real-time Energy Benchmarking Parameter for Lift Systems under different Traffic Control Schemes
Authors: So Albert Ting Pat , Chan Ricky , Kaczmarczyk Stefan 
Published: January 2019

At present, there are benchmarking parameters to assess the energy performance of lifts, e.g. one in Germany adopted by VDI (4707-1/2), one internationally published by ISO (BS EN ISO 25745-2:2015), and the other in Hong Kong adopted by The Hong Kong Special Administrative Region (HKSAR) Government. These parameters are mainly checking and governing the energy consumed by a lift drive without considering real time passenger demands and traffic conditions, the one in Hong Kong pinpointing a fully loaded up-journey under rated speed while the two in Europe pinpointing a round trip, bottom floor to top floor and return with an empty car, though including energy consumed by lighting, displays, ventilation etc. A holistic normalization method (So et al 2005, Lam et al 2006) was developed more than ten years ago by the first author of this article, which can simultaneously assess both drive efficiency and traffic control performance, termed <J/kg-m> which is the name of the parameter measured in unit, J/kgm, and is now adopted by the HKSAR Government as a good practice in the Technical Guidelines of the Energy Code, but not yet enforced in the mandatory code. In Europe, the energy unit of Wh has been used but here, the unit of Joule (J), i.e. Ws, is adopted to discriminate the difference between the two concepts. In this article, such parameter is evaluated under different drives and lift traffic control scenarios by using computer simulations, with the aim of arriving at a reasonable figure for benchmarking an energy efficient lift system with both an efficient drive as well as an efficient supervisory traffic control. This parameter could also compare the performance of different types of intelligent car dispatcher.