bluuebunny/crossref_metadata_2025_split huggingface dataset:
Las rutas posibles de los proyectos de innovación: un análisis de casos
Authors: Rosales Ch´avez Jonatan , Cruz L´opez Lucio , Dom´ınguez  Arce Dayan , Parra Castrillón José Eucario 
Published: April 2019

El objetivo de este artículo es hacer un análisis sobre alternativas metodológicas de los proyectos de innovación empresarial y social y la necesidad de su alineación con estrategias generales de las organizaciones. Se exhibe un compendio conceptual sobre tipologías, modelos y metodologías para el desarrollo de innovaciones y se hace un análisis con base en unos casos de proyectos fallidos: una solución de software para un problema de logística, una iniciativa de red de pequeñas cooperativas, un modelo de gestión del conocimiento y una propuesta de teletrabajo y e-learning para la educación. La situación problemática considera que hay dilemas sobre las rutas de las innovaciones debido a perspectivas que las ubican a veces como estrategia para la competitividad cuando el ámbito es empresarial o para agregar valor a los beneficios cuando es social, pero también en otras ocasiones, como realizaciones con sentido esnobista para satisfacción de intereses personales o coyunturales. La reflexión central es que los proyectos de innovación deben conjugar metodologías globales con realidades y protocolos específicos de sus contextos e independiente de su tipología, deben congregar a los interesados para consensos y aportes colaborativos.
Alteration of denitrifying microbial communities by redox mediators available at low temperature
Authors: Yuan Hongying , Li Yuanling , Zhang Xiaoya , Wang Xue , Wang Hongybin 
Published: April 2019

Abstract
Four sequential batch reactors (SBRs) containing synthetic sewage for denitrification were investigated in this study. Three of them had added one of the three redox mediators, which were anthraquinone-1,5-disulfonate (AQDS), 1,2-naphthoquinone-4-sulfonate (NQS), and 2-hydroxy-1,4-naphthoquinone (LAW), operated at 20 °C and 10 °C, and an additional one to serve as the control. Results showed that 10 °C inhibited denitrification to a considerable extent, but the addition of mediators increased the denitrification rate and efficiency. The total nitrogen removal efficiency increased in the presence of three different redox mediators (100 μmol/L), among which LAW express the best accelerating effectiveness at normal temperature and NQS at low temperature. This may be due to the growth of microorganisms, whose community compositions changed considerably when the different redox mediators were added. Therefore, Illumina MiSeq sequencing was used to identify the different microbial communities. Thauera was dominant at 10 °C (25.60%). Furthermore, the addition of mediators greatly promoted Thauera growth (31.11%–42.41%), especially LAW (42.41%). At 20 °C, Candidatus Competibacter (8.31%–9.59%) and Denitratisoma (6.33%–7.39%) were dominant. Thauera and Denitratisoma are denitrifiers. These results could improve understanding of the sewage biological process at low temperature.
Influences of Masticatory Function Recovery Combined with Health Guidance on Body Composition and Metabolic Parameters
Authors: Takeuchi Hiroaki , Terada Mika , Kobayashi Kazuko , Uraguchi Masahide , Nomura Yoshiaki , Hanada Nobuhiro 
Published: April 2019

Background:
Tooth loss reduces masticatory function. Insufficient masticatory function causes an increase in carbohydrate intake while decreasing the intake of foods with a low Glycemic Index (GI) and high in protein, antioxidants, dietary fiber, vitamins, and minerals. Protein-energy malnutrition may lead to metabolic syndrome, frailty, and faster onset of Non-Communicable Diseases (NCDs). Individuals with tooth loss resulting in problematic eating habits require behavior modification and health guidance.

Objective:
This report aims to evaluate the influence of dental prostheses combined with health guidance on body composition and metabolic parameters.

Methods:
Data were collected from three subjects: Two with molar loss and one with edentulism. Masticatory function was restored in each subject through prosthodontic treatment. Masticatory performance was evaluated before and after the prosthodontic treatment by having the subjects chew a gummy jelly and measuring the glucose extraction. Questionnaires were used to assess food intake and lifestyle habits. Health guidance based on the results of the questionnaires was conducted simultaneously with the prosthodontic intervention. Body composition and blood pressure were measured and blood tests were performed at baseline and around 90 days after the first health guidance session.

Results:
Masticatory ability, body-mass index, basal metabolism standard value, body-fat percentage, and intake of certain nutrients improved in all cases. Blood pressure and hemoglobin A1c improved in two cases.

Conclusion:
Masticatory function recovery combined with health guidance was effective in preventing the onset or deterioration of NCDs in patients with masticatory dysfunction.
Use of 3D Imaging for Treatment Planning in Cases of Impacted Canines
Authors: Portelli Marco , Nucera Riccardo , Fastuca Rosamaria , Cicciù Marco , Lo Giudice Antonino , Militi Angela 
Published: April 2019

Background:
The use of 3D imaging offers the possibility to improve diagnosis and treatment planning in several fields of dental science.

Objective:
The aim of this study is to evaluate the usefulness of 3D evaluation for surgical exposure treatment planning in cases of impacted canine.

Methods:
This retrospective study has been conducted on the clinical reports of twenty patients (11 F - 9 M) with a mean age of 15.4 years, affected by the impacted canine. Each patient underwent a CBCT exam (Hitachi MercuRay, Hitachi Medical Technology, Tokyo, Japan), in order to obtain sagittal, axial and coronal images and a 3D surface rendering. The images have been evaluated by 14 experts orthodontists who were divided into two groups. The first group first evaluates the bidimensional images and then the 3D images and the second group instead has done exactly the opposite. Each orthodontist has elaborated a treatment plan for the impacted canine correction with a specific indication about surgical exposure approach (Palatal-Vestibular) and orthodontic biomechanics.

Results:
The level of concordance in treatment planning of the 3D images evaluation and the bidimensional images was found to be greater in the second group of orthodontists. Moreover, in this group, the time spent for the treatment plan has been lower than in the first group (12 ± 3.32 min vs. 23 ± 2.53 min, p < 0.05).

Conclusion:
According to the results of the present study, it is possible to state that CBTC is fundamental for the diagnosis and treatment planning of impacted canine. However, further studies are necessary to confirm the greater reliability of 3D surface rendering compared to the bidimensional images.
Antibacterial and Antioxidant Activities of Nasturtium officinale Essential Oil on Food Borne Bacteria
Authors: Mahdavi Saman , Kheyrollahi Mojtaba , Sheikhloei Hossein , Isazadeh Alireza 
Published: April 2019

Introduction:
The use of synthetic preservatives has been increasing in the food industry, and this leads to an increased incidence of gastrointestinal diseases and cancers in humans in the long run.

Aims & Objectives:
The aim of this study was to investigate the antibacterial and antioxidant activities of Nasturtium officinale essential oil on some important food borne bacteria.

Materials & Methods:
In this study, the antibacterial activity of N. officinale essential oil was evaluated on Staphylococcus aureus, Bacillus cereus, Escherichia coli and Salmonella enteric by microdilution method. Also, the antioxidant activity of this essential oil was evaluated by inactivating free radicals produced by 2,2-diphenyl-1-picrylhydrazyl (DPPH). Finally, the chemical compounds of the N. officinale essential oil were evaluated by gas chromatography- mass spectrometry (GC/MS).

Results:
The results showed that S. enteric and E. coli isolates had the most resistance and B. cereus isolates had the most susceptibility to N. officinale essential oil. The evaluation of antioxidant properties showed that in the same concentrations, the antioxidant effect of N. officinale was less than BHT. The obtained results from GC/MS showed that Phytol (30.20%) was the highest proportion and Megastigmatrienone 2 (0.18%) was the lowest proportion of essential oil.

Conclusion:
In general, the results of this study showed that N. officinale essential oil has an appropriate antibacterial activity against gram positive bacteria and can be used as a new antibacterial and antioxidant compound in the food industry.
Subdural collections of infancy and setting sun sign may be asymptomatic and benign or symptomatic and aggressive
Authors: Lucas César de Paula , Martins Luiz F. , Júnior Valter Da Costa , Carneiro Sandoval , Costa Vanessa Maia da , Siqueira Raquel Andrade , Prandini Mirto Nelso 
Published: April 2019

Objective: subdural collections of infancy may be asymptomatic and benign or symptomatic and agressive. We present two cases illustrating both clinical scenarios. The presence of setting-sun sign is an unusual feature in both cases. Clinical presentation: the diagnosis of benign subdural collections of infancy depends on several distinct clinical and laboratory findings, which are reflected in these two cases: patient age less than 1 year, macrocrania (Case 1 was 79 cm), normal psychomotor development, no history of CNS infection or head trauma; subdural fluid clear yellow; erythrocyte count less than 1 ml/mm³. Both cases presented with setting sun sign. CT scans showed craniofacial disproportion, disjunction of the sutures, low measures of attenuation coefficient values, relatively normal ventricular size, and no cerebral atrophy. MRI also showed agenesis of the corpus callosum, in case 1. Intervention: based on megacrania associated with poor visualizations of the cerebral sulci, Case 1 was treated with a subdural collection-peritoneal shunt; Case 2 was treated with clinical observation due to enlarged subarachnoid spaces. Conclusion: we present two cases with different clinical courses - one more aggressive than the other. We believe these two cases illustrate a disease process that is not always benign, particularly in view of setting-sun sign, and thus warrants a more accurate terminology. Regardless of terminology, however, even symptomatic cases can have good outcome with conservative treatment. Good outcome relies on close observation associated with complete workup that evaluates signs and symptoms of discompensation.
Apendicite aguda em criança com derivação ventriculoperitoneal
Authors: Pereira Carlos Umberto , Braz Priscila Cardoso 
Published: April 2019

Apendicite aguda em paciente portador de hidrocefalia e submetido à derivação ventriculoperitoneal pode ser de difícil diagnóstico diferencial com quadro de infecção do shunt, em virtude das manifestações clínicas serem semelhantes. Entretanto, a nãoidentificação de uma dessas afecções e a ausência de tratamento adequado em tempo hábil poderão ocasionar danos severos. Os autores apresentam um caso de apendicite aguda em uma criança de 6 anos de idade, com diagnóstico de hidrocefaliacongênita e portadora de derivação ventriculoperitoneal. Após a realização da apendicectomia e da antibioticoterapia sistêmica,a paciente evoluiu de maneira satisfatória, sem ser necessária a remoção do sistema de drenagem.
Frontal Epidural Haematoma
Authors: Pereira Carlos Umberto , Leão João Domingos Barbosa Carneiro , Ribas Antonio , Santos Egmond Alves Silva , Monteiro João Tiago Silva , Duarte Gustavo Cabral 
Published: April 2019

Background: The epidural haematoma is the most important space-occupying lesion due to head injury with high index of mortality and morbidity when the correct management is not done. Frontal epidural haematoma are considered rare lesions, representing about 10% of the whole epidural haematomas. They are usually unilateral and may present with subacute and chronic evolution in 40% of the cases. Objective: To study thirty cases of frontal epidural haematoma andanalyze the causes, clinical findings, evolution, and outcome. Patients and Methods: Thirty patients presenting with frontal epidure hematomas were retrospectively reviewed. The age ranged from 10 to 32 years old, with a mean of 18 years-old. Main causes were traffic accidents and falls. Results: In therewere 24 male patients and six female cases the haematoma was bilateral. Acute collection occurred in 19 cases, subacute in 5 and chronic in 6 of them. The most important clinical findings were headaches, vomiting and seizures. Skull x-raysdetected fracture in 18 cases and computed tomography was positive in demonstrating the haematoma. In all surgery cases was carried out in 28 patients and two cases had been submitted to conservative treatment. Two patients died in consequence of associated intracerebral and extracerebral lesions. Conclusions: 1) usually frontal epidural haematomas are more frequent in young adults; 2) its evolution is slow, usually subacute or chronic, in the majority of the cases; 3) its clinical findings course with few neurological symptoms and 4) the prognosis is good, except in those cases with multiple intracranial lesions or systemic injury.
Internal carotid pseudoaneurysm after transsphenoidal resection of a pituitary adenoma
Authors: Lázaro Bruno C. R. , Flores Marlo S. , Júnior Orlando M. , Landeiro José A. 
Published: April 2019

We present a case of pseudoaneurysm formation after endonasal endoscopic transsphenoidal resection of a pituitary adenoma, with an endovascular treatment proposal: as the patient failed in balloon catheter occlusion test of the internal carotid artery, an alternative model of treatment was proposed,consisting of using detachable coils and placing a stent in the internal carotid artery adjacent to the vascular formation. After a dramatic initial presentation of a massive epistaxis, the patient had a significant improvement after treatment.
Proliferar ou diferenciar? Perspectivas de destino das células-tronco
Authors: TT Schwindt , GF Barnabé , LEAM Mello 
Published: April 2019

Objetivo: Células-tronco embrionárias (CTE) têm o potencial para serem aplicadas em ampla variedade de doenças e podem também ser a melhor fonte de tecido humano para o teste de novas drogas in vitro. Contudo, existem aspectos éticos, a respeito de seu isolamento e cultivo, que envolvem a geração de novos embriões. Outros estudos mostraram que, em tecidos adultos, podem existir células-tronco, embora essas sejam menos plásticas do que as CTE. Entre os dois extremos, existem as células-tronco tecido específicas, isoladas de tecidos em desenvolvimento. Durante o desenvolvimento do sistema nervoso central (SNC), é possível encontrar células-tronco em regiões específifi cas, como a zona subventricular (ZSV) e o hipocampo. Estas células podem ser as candidatas ideais para transplantes neurais. O objetivo deste artigo é dar uma visão geral do campo da pesquisa com células-tronco. Conclusão: Os estudos sobre CT têm gerado grandes perspectivas na área da medicina, porém os resultados ainda são preliminares e por essa razão torna-se necessária muita cautela na execução e divulgação de novas terapias celulares, aumentando o entendimento dos mecanismos moleculares envolvidos na proliferação e diferenciação das CT, finalmente as promessas de sua utilização em diversas terapias celulares poderão ser cumpridas.
Comparision between the clinical and surgical treatment in carpal tunel syndrome by means of electrophysiological analysis
Authors: Sparapani Fábio V. C. , De Aguiar Paulo Henrique Pires , Zicarelli Carlos A. M. , Hirata Maria T. A. , Tedesco-Marchese António J. , Teixeira Manoel Jacobsen 
Published: April 2019

Introduction: The carpal tunel syndrome in the most common of the compression syndromes. It is characterized by pain, weakness of fine movements and paresthesias in the first four fingers of the hand. Diagnosis is confirmed by neurological examination and recently the electroneuromiography (ENMG) is useful to define prognosis. Objective: The authors analysed 33 patients, both fistis presenting with carpal tunnel syndrome, by means of electrophysiological studies in order to compare the clinical and surgical treatment. Casuistics and method: Twenty five patients (42 hands) were successfully submitted to clinical treatment and 16 patients (18 hands) were submitted to surgical treatment. The clinical treatment consisted in immobilization, pyridoxine administration and eventually antiinflammatory drugs for a three-months stipulated period. The surgical treatment consisted in complete longitudinal section of transverse carpal retinaculum and recovery was analysed electrophysiologically by means of ENMG before and over 3 months after treatment. In the non-surgical group, sensitive velocity increased in most of the patients, however amplitudes had overall no changes. Conclusion: Surgical treatment accelerates recovery in all aspects of electrophysiological anlysis corresponding to neurological recovery. ENMG should be also advocated in the cases of absence and/or slow recovery.
Aplasia cútis congênita com hemorragia fatal do seio sagital
Authors: Fagundes-Pereyra Walter J. , De Sousa Larissa , Quadros Ricardo , De Souza Filho Carlos Batista Alves 
Published: April 2019

Objetivo: A aplasia cútis congênita (ACC) é uma doença rara, caracterizadapela ausência congênita da epiderme e da derme. Os casos de evoulção fatal são mais raros ainda. Relato de caso: os autores relatam caso de recém-nascido, sexo masculino, apresentando falha mediana no couro cabeludo, estendendo-se da fontanela anterior à posterior, envolvendo seio sagital superior, medindo 2,5 x 6,5 cm, coloração arroxeada e exposição de dura-máter, caracterizando a aplasia cútis. Foi encaminhado ao Serviço de Neurocirurgia da Santa Casa de Belo Horizonte (MG) com um mês de vida, com história de múltiplos episódios hemorrágicos e com sangramento ativo na lesão. Foi submetido à cirurgia de urgência para fins hemostáticos, tendo sido evidenciada comunicação direta com seio venoso. A criança faleceu após dois dias. Conclusão: conclui-se que o tratamento precoce de ACC seja imperativo, uma vez que na maioria das vezes, seja o tratamento conservador ou cirúrgico, obtêm-se sucesso. É importante um maior conhecimento das equipes multidisciplinares envolvidas com intuito de reduzir as hemorragias e demais complicações associadas.
Unusual presentation of dermatofibrosarcoma protuberans
Authors: Mattei Tobias Alécio , Ramina Ricardo , Aguiar Paulo Henrique , Milano Jerônimo Buzetti , Mandarino Daniel Pereira 
Published: April 2019

Dermatofibrosarcoma protuberans is a rare neoplasm, usually presenting as a low-grade, non-invasive, slow-growing tumor, with a pronounced tendency to local recurrence. We present a rare case of a high-grade, histologically undifferentiated lesion, which eroded underlying bony structures. A wide local excision with careful pathologic analysis of margins was performed with immediate reconstruction of skull bone and musculo-cutaneous flap transposition in order to cover the skin defect. A one-stage surgical procedure, such as presented in this report, is the treatment of choice recommended by the authors.
Investigação neuropsicológica pré-operatória em pacientes com glioma de baixo grau
Authors: Da Silva Maria Carla , Miotto Eliane Correa , De Lucia Mara Cristina Souza , De Aguiar Paulo Henrique Pires 
Published: April 2019

Objetivo: Os gliomas de baixo grau (LGG) são tumores decrescimento lento e com um comportamento clínico heterogêneo,onde muitos pacientes não apresentam sintomas neurológicosou cognitivos observáveis, entretanto, quando taispacientes são submetidos a tratamento químioterápico ouradioterápico, observam-se em alguns casos alterações cognitivasmuitas vezes não associadas apenas com o tratamentorecebido. Nestes casos há a possibilidade de tais pacientes jáapresentarem previamente ao tratamento alterações cognitivassutis identificadas apenas através de exame neuropsicológico.O objetivo deste estudo é investigar as funções cognitivasde pacientes com gliomas de baixo grau antes do tratamentocirúrgico ou medicamentoso. Método: 13 pacientes com LGG foram submetidos à avaliaçãoneuropsicológica com testes psicométricos. Resultados: Todos os pacientes apresentaram déficit cognitivosem mais de duas funções cognitivas, sendo memória episódicaverbal e funções executivas as mais prejudicadas. Oitopacientes (62%) apresentaram déficit grave de memória episódicaverbal imediata, sete (54%) de tardia e quatro (31%)de reconhecimento. Quanto às funções executivas, 92 % dospacientes apresentaram déficit de fluência verbal nominal e77% de fluência verbal categórica, variando entre leve e grave.85% dos pacientes apresentaram déficit de flexibilidademental e de velocidade de processamento de informações. Conclusão: Demonstrou-se a importância de submeter estapopulação de pacientes à avaliação neuropsicológica antesdo tratamento para que, assim, os resultados pormenorizadosobtidos possam direcionar o tratamento de forma mais efetiva,minimizando possíveis conseqüências funcionais para o paciente.
Nível de conhecimento da população adulta sobre acidente vascular cerebral (AVC) em Pelotas - RS
Authors: Costa Fernando , Oliveira Sandro , Magalhães Pedro , Costa Betânia , Papini Raulério , Silveira Miguel , Lang Martha 
Published: April 2019

Introdução: O acidente vascular cerebral (AVC) é uma importante causa de morbimortalidade, sendo a primeira no Brasil. Conhecimento sobre fisiopatologia, fatores de risco, sintomas e conduta da população em geral, constitui uma importante arma contra estes índices desfavoráveis. O estudoprocura avaliar o nível de conhecimento da população sobre o AVC. Metodologia: realizamos um estudo transversal de base populacional com 483 indivíduos de 20 anos ou mais residentes na zona urbana de Pelotas, entrevistados em seus domicílios a partir de um processo amostral em múltiplos estágios. Resultados: o nível de conhecimento foi considerado inadequado em 97,7% dos indivíduos para a conduta; em 73,7% para a fisiopatologia; em 71,4% para sinais e sintomas e em 53,7% para fatores de risco. O principal fator de risco identificado para o mau desempenho foi a baixa escolaridade. Conclusão: Investimentos em campanhas educativas devemser priorizados para a prevenção e o tratamento do AVC.
Fundamentos da anatomia endoscópica ventricular para terceiro-ventriculostomia
Authors: Romero Alicia Del Carmen Becerra , Gomes Pinto Fernando Campos , De Aguiar Paulo Henrique Pires 
Published: April 2019

Introdução: Certamente um dos elementos mais importantes para o sucesso de intervenções endoscópicas no sistema ventricular é a habilidade do neurocirurgião em reconhecer as estruturas anatômicas e utilizar essa informação para orientação. Material e Métodos: A literatura sobre o tema é revisada, focalizando nas referências anatômicas importantes para a terceiro ventriculostomia, no ventrículo lateral: forame de Monro, plexo coróide, veia septal, veia tálamo-estriada. Dentro do terceiro ventrículo os seguintes reparos anatômicos são importantes: corpos mamilares, tuber cinéreo e infundíbulo.Resultados: Uma das principais estruturas para orientação no corno frontal do ventrículo lateral é o plexo coróide. O assoalho do terceiro ventrículo tem importante relação cirúrgica com o ápex da artéria basilar, cujo rompimento é uma das piores complicações da terceiro ventriculostomia. Nas paredes laterais do terceiro ventrículo estão importantes grupos nucleares hipotalâmicos, principalmente o núcleo arqueado e paraventricular. Além disso, a fenestração deve ser sempre realizada na linha média, pois uma fenestração lateral pode danificar o terceiro nervo craniano ou artérias pré-mamilares, resultando em isquemia talâmica ou hipotalâmica. Conclusão: Entender a microanatomia das estruturas neurais e vasculares nos ventrículos laterais e terceiro ventrículo para a realização de terceiro ventriculostomia é essencial para melhorar os resultados cirúrgicos, evitando complicações.