bluuebunny/crossref_metadata_2025_split huggingface dataset:
Being kind to ourselves: group compassion-focused therapy (CFT) versus treatment as usual (TAU) to improve depression and anxiety in dementia – a protocol for a mixed-methods feasibility randomised controlled trial within the NHS
Authors: Spector Aimee , Melville Melissa , Craig Catriona , Henderson Catherine , Hiskey Syd , Knapp Martin , Kusel Yvette , Oliver Keith , Robinson Louise , Royan Lindsay , Stott Joshua , Williams Lisa , Evans Rachel 
Published: December 2024

IntroductionDepression and anxiety are common in dementia, with a devastating impact. However, there remains a lack of evidence-based psychological therapies for this clinical group. Compassion-focused therapy (CFT), a talking therapy which addresses feelings of shame and stigma, has shown benefits in other clinical populations. This study is a mixed-methods feasibility randomised controlled trial (RCT) of group CFT for people with dementia and symptoms of anxiety and/or depression, to determine if a future definitive RCT is feasible.Methods and analysis50 people with mild-to-moderate dementia and symptoms of anxiety and/or depression will be randomised to either the intervention arm (12 sessions of group CFT plus treatment as usual (TAU)) or the control arm (TAU). Primary outcome measures include the feasibility of conducting an RCT in terms of recruitment, acceptability, suitability of secondary outcome measures and fidelity. Blind assessments will be conducted at baseline, approximately 16 weeks and 6 months follow-up, to collect data on depression, anxiety, quality of life, quality of the carer–patient relationship, cognition, self-compassion and carer burden. Qualitative interviews will be used to gather participant, carer/supporter and clinician perspectives on the value, acceptability and feasibility of the intervention.Ethics and disseminationThis study has been approved by the London Riverside REC (Ref: 23/LO/0535) and the Health Research Authority (HRA) ethical approval process through the Integrated Research Application System (IRAS ID: 327086). We plan to publish the results in open-access peer-reviewed journals, present data at conferences and provide feedback to the study participants, sponsors and funders.Trial registration numberISRCTN20868432.
Transcription Factor 21 Regulates Cardiac Myofibroblast Formation and Fibrosis
Authors: Johansen Anne Katrine Z. , Kasam Rajesh K. , Vagnozzi Ronald J. , Lin Suh-Chin J. , Gomez-Arroyo Jose , Shittu Adenike , Bowers Stephanie L.K. , Kuwabara Yasuhide , Grimes Kelly M. , Warrick Kathrynne , Sargent Michelle A. , Baldwin Tanya A. , Quaggin Susan E. , Barski Artem , Molkentin Jeffery D. 
Published: December 2024

BACKGROUND:
TCF21 (transcription factor 21) is a bHLH (basic helix-loop-helix) protein required for the developmental specification of cardiac fibroblasts (CFs) from epicardial progenitor cells that surround the embryonic heart. In the adult heart, TCF21 is expressed in tissue-resident fibroblasts and is downregulated in response to injury or stimuli leading to myofibroblast differentiation. These findings led to the hypothesis that TCF21 regulates fibroblast differentiation in the adult mammalian heart to affect fibrosis.

METHODS:

Tamoxifen-inducible Cre genetic mouse models were used to permit either
Tcf21
gene deletion or its enforced expression in adult CFs. Histological and echocardiographic analyses were used, as well as transcriptomic analysis to determine the consequences of TCF21 gain-of-function and loss-of-function in vivo. Genomic
Tcf21
occupancy was identified by chromatin immunoprecipitation and sequencing in CFs. Myocardial infarction and AngII (angiotensin II)/phenylephrine served as models of cardiac fibrosis.

RESULTS:

Acute and long-term deletion of
Tcf21
in CFs of the adult mouse heart does not alter fibroblast numbers, myofibroblast differentiation, or fibrosis. Fibroblast-specific
Tcf21
gene–deleted mice demonstrate no significant alterations in cardiac function or scar formation in response to cardiac injury compared with control mice. In contrast, enforced expression of TCF21 in CFs inhibits myofibroblast differentiation and significantly reduces cardiac fibrosis and hypertrophy in response to 1 week of Ang II/phenylephrine infusion. Mechanistically, sustained TCF21 expression prevents the induction of genes associated with fibrosis and ECM (extracellular matrix) organization.

CONCLUSIONS:
TCF21 expression is not required to maintain the cell state of CFs in the adult heart. However, preventing the normal downregulation of TCF21 expression with injury reduces myofibroblast formation, cardiac fibrosis, and the acute cardiac hypertrophic response following 1 week of Ang II/phenylephrine stimulation.
Sex Differences in Nonadherence to Secondary Stroke Prevention Medications Among Patients With First‐Ever Ischemic Stroke
Authors: Chen Chen , Reeves Mathew J. , Farris Karen B. , Morgenstern Lewis B. , Lisabeth Lynda D. 
Published: December 2024

Background
More women than men experience recurrent strokes. Medication adherence is critical to prevent recurrence; however, studies investigating sex differences are limited. We examined sex differences in poststroke medication adherence, overall and by drug class, and identified influencing factors.

Methods and Results

Patients with first‐ever ischemic stroke were identified from a population‐based study (2008–2019). At 90 days after a stroke, self‐reported medication adherence was defined as never or rarely missing a dose in a typical week for each secondary stroke prevention medication (antihypertensives, cholesterol‐lowering drugs, antiplatelets, anticoagulants). We generated prevalence ratios (PRs) using modified Poisson models to assess sex differences with and without adjustment for potential confounding factors, including demographics, social factors, health system–related, lifestyle‐related, health condition–related, prestrokehealth–related, and stroke‐related factors. Among 1324 participants (48.4% women, 58.0% Mexican American individuals), women were more likely to report nonadherence to cholesterol‐lowering drugs (PR, 1.80 [95% CI, 1.14–2.84]) and antiplatelets (PR, 1.53 [95% CI, 1.003–2.34]). Adjusting for obesity attenuated while adjusting for age, marital status, access to care, smoking, and alcohol consumption accentuated sex differences. Race and ethnicity modified the sex difference in nonadherence to cholesterol‐lowering drugs (
P
interaction
=0.054) such that the sex difference was larger in Mexican American individuals (PR, 3.00 [95% CI, 1.65–5.48]) than in non‐Hispanic White individuals (PR, 1.30 [95% CI, 0.52–3.27). No significant sex differences were found for nonadherence to antihypertensives and overall nonadherence.

Conclusions
Poststroke medication nonadherence was more prevalent among women than men. This was partially due to the confounding effects of lifestyle, marital status, and access to care, suggesting potential subgroups for interventions to improve adherence.
“Let Our Camp Be Pure”: The Views and Personality of Mordechai Narkiss, “The First Hebrew Curator,” Through His Critiques of Writers on Jewish Art in the 1920s–1950s
Authors: Sabar Shalom 
Published: December 2024

Abstract
Mordechai Narkiss (1897–1957), the first and long-serving curator of the Bezalel Museum in Jerusalem, was a pioneering scholar in Jewish art history. His significant contributions to the field are epitomized by his insightful critiques, written in Hebrew, of the leading scholars in his era. Narkiss’s rigorous reviews, reinforced by his deep immersion in Jewish tradition and extensive knowledge of the visual arts across various cultures, adeptly identified errors, unfounded assumptions, and methodological shortcomings. He underscored the importance of a solid foundation in both Judaism and art history. This article explores six of Narkiss’s critical reviews of seminal works in the field: Karl Schwarz, Die Juden in der Kunst (1928), Cecil Roth, The Casale Pilgrim (1929), Ernst Cohn-Wiener, Die jüdische Kunst (1929), Rachel Wischnitzer, Symbole und Gestalten der Jüdischen Kunst (1935), Franz Landsberger, Einführung in die Jüdische Kunst (1935), and Jacob Pinkerfeld, Synagogues of Italy (1954). It elucidates the complexities and debates within Jewish art historiography, highlighting Narkiss’s pivotal role in both critiquing and shaping scholarly discourse and emphasizing the ongoing relevance of meticulous research in Jewish art history.
Engaging with Social Media to Spread the Gospel in Pandemic Times
Authors: Montañés Jiménez Antonio 
Published: December 2024

Abstract
This article engages with sociological and anthropological conversations about the digital experiences of cultural and religious minorities during the COVID-19 pandemic by investigating how some Pentecostal Gitanos seized the online world to spread the Gospel in Spain. The article features two ethnographic studies of my Pentecostal Gitano interlocutors. Modalities of digital religious engagement analyzed include testimonies, WhatsApp broadcast lists, praise songs, and praying. The article’s main argument is that the pandemic created a social media-enabled window of opportunity for some Gitano believers to reach out to new potential converts and claim online spaces for God. Extensive involvement in social media activities by Pentecostal Gitanos may also be understood as a tool to challenge and question an increasingly secular Spanish society that, during the pandemic, was perceived as dismissive of the spiritual aspects shaping the development of the global health crisis.
Rosary Unites
Authors: Zasanska Nadia 
Published: December 2024

Abstract
The article addresses the project “Rosary Unites” of the Ukrainian Greek Catholic Church (UGCC) to understand recent changes in religious practices, religious identity, and communication policy of the minority church during the war in Ukraine. The UGCC attempts to reproduce the communication policies of the Catholic Church, so it inevitably enacts its religious practices into Greek Catholic tradition. During the war, the UGCC, as a minority church, uses digital media to be more visible in the public realm: to address and bind all people of Ukraine regardless of their religious self-identification. As a result, online rosary prayer serves as the expression of Ukrainian identity, solidarity, national unity, and resilience in a time of war.
Description of the male Gonatopus pinhalensis (Dryinidae, Gonatopodinae) supported by DNA barcoding and new host records
Authors: Martins André Luis , Barros Muniz David , Domahovski Alexandre Cruz 
Published: December 2024

Abstract
Gonatopus Ljungh, 1810, third most diverse genus within the Dryinidae, exhibits marked sexual dimorphism, posing challenges in associating sexes. This study focuses on Gonatopus pinhalensis Martins, 2020, a species with limited sexual association records. Through DNA barcoding, we establish the first sexual association for this species, utilizing specimens obtained from different hosts. The male and female specimens exhibited a 1.92% pairwise difference in their mitochondrial COI sequences, confirming their conspecificity. Morphological description for the male and additional material are provided, emphasizing external features due to limited information on male genitalia. Host associations with Amplicephalus sp., Copidinomus vittulatus, Stirellus picinus, Graminella striatella, and Metadelphax argentinesis were documented. The study highlights the significance of DNA barcoding in overcoming challenges posed by the sexual dimorphism of Gonatopus species. This research contributes to the understanding of Dryinidae fauna, not only in Brazil but also in the Neotropic, emphasizing the need for further breeding studies and continued molecular techniques application.
Evaluation, Calibration, and Application of Probabilistic 100-m Wind Speed Forecasts Produced by the WRF Ensemble Prediction System in Taiwan
Authors: Chou Shih-Chun , Chang Hui-Ling , Toth Zoltan , Lin Pay-Liam , Hong Jing-Shan , Wu Yuan-Kang , Chen Guan-Ru , Lu Kuo-Chen , Cheng Chia-Ping 
Published: December 2024

Abstract
The use of renewable energy is on the rise; however, it brings more challenges for grid operations and unit scheduling due to the intermittent nature and limitations in predicting renewable power generation. High-quality meteorological forecasts play a critical role in the effective application and management of renewable energy resources. This study evaluates the quality and economic benefits of probabilistic forecasts for 100-m wind speeds from the Weather Research and Forecasting Model ensemble prediction system (WEPS). A multiple linear regression (MLR) method for calibration is also used to improve forecast quality. Additionally, this study explores the application of probabilistic hub-height wind speed forecasts in conjunction with an economic value analysis to determine whether wind turbines should be shut down during typhoon periods. The findings reveal that the forecast in the central offshore region of Taiwan exhibits the highest reliability and discrimination ability compared to those in the northern and southern regions. Additionally, employing the MLR calibration method significantly improved the reliability and discrimination ability of the probabilistic forecasts compared to the raw forecasts. Furthermore, during the typhoon seasons, almost all users, regardless of their cost–loss ratio, can benefit from basing their decisions on WEPS forecasts compared to using a single deterministic forecast. Importantly, decision-makers can benefit more from probabilistic forecasts than the ensemble mean forecasts when both are derived from the same ensemble prediction system, since the former incorporates forecast uncertainty.

Significance Statement
High-quality meteorological forecasts significantly influence the efficient utilization and management of renewable energy resources. Therefore, this study uses a simple yet effective approach to correct systematic bias in probabilistic wind speed forecasts over Taiwan, aiming to provide decision-makers with more reliable forecasts for hub-height wind speeds. Given that strong winds during typhoon periods pose safety concerns for wind turbine operation, we use an economic value analysis to assist turbine operators in deciding whether to shut down wind turbines. Furthermore, our research demonstrates that ensemble probabilistic forecasts can yield greater economic benefits for decision-makers when compared to the commonly used ensemble mean forecasts.
The Importance of Eddy Stirring in Wind-Driven Coastal Upwelling
Authors: Li Dou , Wei Huaiyu , Ruan Xiaozhou 
Published: December 2024

Abstract
Coastal upwelling systems play a key role in sustaining productive coastal ecosystems in the global ocean by transporting nutrients to surface waters. However, the fundamental mechanisms and pathways responsible for nutrient upwelling are not fully understood, largely due to the historically employed two-dimensional frameworks in which coastal upwelling systems have long been studied. Using both observations and idealized numerical simulations, we identify and quantify two primary routes of nutrient upwelling: the residual circulation, resulting from a significant cancellation between Eulerian-mean and eddy-induced circulations, and along-isopycnal eddy stirring. Our analysis demonstrates that their relative contributions depend on two distinct parameters: 1) the slope Burger number S, defined here as S = αN/f, where α is the topographic slope angle and N and f are the buoyancy and Coriolis frequencies, and 2) the surface nutrient uptake rate by biological activities. Specifically, we propose that wind forcing induces isopycnal tilting and surface outcropping, which creates favorable conditions for along-isopycnal nutrient gradients to develop in regions of strong biological activity at the surface. The magnitude of these gradients depends on both the slope Burger number S, which influences the strength of the residual circulation bringing nutrients from depths, and the surface biological uptake rate, which consumes nutrients. Our diagnostics provide insights into the intricate pathways for nutrient upwelling and underscore the significance of eddy stirring in coastal upwelling systems.
Ablation and mechanical properties of carbon/high silica/phenolic composites: Using experimental analysis and five machine learning models for correlating and generalizing to diverse compositional ratios
Authors: Karimi S. , Kamel Tousi Mohammad 
Published: December 2024

This paper investigates the thermal and mechanical properties of carbon/high silica/phenolic composites with varying reinforcement ratios. Five hybrid samples were fabricated: 100% carbon, 75% carbon/25% silica, 50% carbon/50% silica, 25% carbon/75% silica, and 100% silica. A three-point bending test evaluated their strength, while an ablation test at 3000°C for 1 minute measured backside temperature, linear ablation rate, and mass ablation rate. Results indicated that the 100% carbon sample had the highest bending strength, while the 50% carbon/50% silica sample achieved the lowest linear and mass ablation rates, demonstrating an effective balance between fire retardancy and insulation, resulting in minimal backside temperature during ablation. Additionally, five machine learning models (Linear Regression, Decision Trees, Random Forests, Gradient Boosting Machines, and Neural Networks) were utilized to predict mass ablation rate, linear ablation rate, and strength. Decision Trees and Gradient Boosting Machines exhibited the highest prediction accuracy, while Linear Regression struggled with non-linear data, resulting in lower accuracy for ablation rate predictions. Notably, these models were also able to generalize to other percentages, showcasing their robustness and versatility in optimizing material compositions beyond the tested scenarios. This study highlights the potential of machine learning in predicting the properties of advanced composites, contributing to the development of high-temperature resistant materials.
The relationship between comfort, personal control and productivity in UK offices
Authors: Marsh Ant , Leech Arthur , van Someren Kate 
Published: December 2024

Occupier experience surveys conducted in UK offices between the years 2012-2022 have been analysed to examine the relationship between (1) satisfaction with indoor conditions (thermal comfort, indoor air quality, lighting, noise), (2) personal control over the conditions and (3) perceived productivity as result of the conditions. The data set contains 111 surveyed buildings and 10,870 individual responses. The findings show that many respondents are both satisfied with the indoor conditions whilst perceiving that they had little to no personal control over them. Six indoor environmental parameters were examined as part of this study. The proportion of respondents that were in the category of ‘satisfied overall’ while having ‘low control’ ranged from 21 to 46%, constituting the largest proportion of respondents for three of the six variables examined. The results also showed that perceptions of productivity in the surveyed buildings were highly correlated with satisfaction with the internal conditions (regardless of perceived personal control over them). Therefore our research indicates that designers should focus on providing satisfactory conditions for the majority of occupants, and not be overly concerned with the provision of greater personal control for office workers. Practical Application The level of personal control provided to occupants in office buildings is an important component of their overall design and manageability. This research helps modern professionals to understand the degree to which personal control over different variables is important to occupants themselves, in terms of their comfort and self-reported productivity. In turn this can help professionals to better understand and therefore assess whether the provision of greater personal control is required or not.
A Transforming Ontology of Boundaries? What Is and What Is Not in the Early Middle Kingdom
Authors: Mourad Anna-Latifa 
Published: December 2024

Ancient Egyptian ontologies have been commonly approached as related to order and chaos. Associated with the latter are the concepts of existence and non-existence, which may be expressed by the verb wn ‘to be’ and its derivatives, as well as the substantive n.tyt ‘what is’ and its negation iw.tyt ‘what is not’. The earliest attestations of n.tyt and iw.tyt are found in the Pyramid Texts, reflecting the importance of (non)existence in cosmic and funerary beliefs. By the Middle Kingdom, n.tyt and iw.tyt occur in titles and epithets of officials, some of whom were involved in boundary formation and traversal. This paper provides an overview of these developments and their insights on Middle Kingdom conceptions of the world. Exploring the role of transregional activities, it questions whether ‘what is’ and ‘what is not’ may reflect an ontology of boundaries connected with socio-political shifts of the early second millennium BCE. [Formula: see text]
Immunohistochemical Expression of Mismatch Repair Proteins in Colorectal Carcinomas with Histopathological Correlation in a Quaternary Care Centre in South India
Authors: George Dona Maria , Lakshminarayanan Mekala , Lakshmanan Archana 
Published: December 2024

Background and Aims: Colorectal carcinomas are one of the most prevalent malignant neoplasms globally and are characterised by a range of genetic and epigenetic alterations, primarily chromosomal instability and microsatellite instability. This study aims to assess the expression of MMR proteins in patients with colorectal carcinoma and to examine the relationship between MMR status and various histopathological and clinical variables. Material and Methods: All biopsy and resection cases of colorectal carcinoma on which MMR was done by IHC were studied from December 2022 to November 2023. Histopathological and immunohistochemical assessments of mismatch repair proteins were done for 153 colorectal carcinoma patients in formalin-fixed paraffin-embedded tumour tissues. Statistical analysis was carried out using SPSS software (IBM, 28.0). Results: Out of 153 cases collected, 23 cases (15%) had a loss of MMR expression, and 130 cases (85%) had no loss of MMR protein. Combined loss of MLH1 and PMS2 was found in 16 cases (70%), combined loss of MSH2 and MSH6 was found in five cases (21%) and isolated loss of PMS2 was found in two cases (9%). Adenocarcinoma NOS, mucinous differentiation, medullary pattern, right-sided tumours, female gender and younger age group correlated with loss of MMR expression. Conclusion: Molecular study is the first approach for detecting MSI associated with CRC, IHC is a very good alternative to identify microsatellite instability. IHC methods can be used as a reliable tool in the workup for MSI as IHC markers (antibodies to the MMR proteins) are now easily accessible in most laboratories.