bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methamphetamine learning induces persistent nonmuscle myosin II-dependent spine motility in the basolateral amygdala
Authors: Young Erica J. , Lin Hua , Kamenecka Theodore M. , Rumbaugh Gavin , Miller Courtney A. 
Published: April 2019

ABSTRACTNonmuscle myosin II inhibition (NMIIi) in the basolateral amygdala (BLA) selectively disrupts memories associated with methamphetamine (METH) days after learning, without retrieval. However, the molecular mechanisms underlying this selective vulnerability remain poorly understood. A known function of NMII is to transiently activate dendritic spine actin dynamics with learning. Therefore, we hypothesized that METH-associated learning perpetuates NMII-driven actin dynamics in dendritic spines, leading to an extended window of vulnerability for memory disruption. Two-photon imaging of actin-mediated spine motility in neurons from memory-related structures, BLA and CA1, revealed a persistent increase in spine motility after METH-associated learning that was restricted to BLA neurons. METH-induced changes to BLA spine dynamics were reversed by a single systemic injection of an NMII inhibitor. Thus, a perpetual form of NMII-driven spine actin dynamics in BLA neurons may contribute to the unique susceptibility of METH-associated memories.
Comparative genomics groups phages of Negativicutes and classical Firmicutes despite different Gram-staining properties
Authors: Rands Chris M , Brüssow Harald , Zdobnov Evgeny M 
Published: April 2019

SummaryNegativicutes are Gram-Negative bacteria characterized by two cell membranes, but they are phylogenetically a side-branch of Gram-Positive Firmicutes that contain only a single membrane. We asked whether viruses (phages) infecting Negativicutes were horizontally acquired from Gram-Negative Proteobacteria, given the shared outer cell structure of their bacterial hosts, or if Negativicute phages co-evolved vertically with their hosts and thus resemble Gram-Positive Firmicute prophages. We predicted and characterised 485 prophages from Gram-Negative Firmicute genomes plus 2,977 prophages from other bacterial clades, and we used virome sequence data from 183 human stool samples to provide independent evidence for our predictions. The majority of the identified Negativicute prophages were lambdoids closer related to prophages from other Firmicutes than Proteobacteria by sequence relationship and genome organization (position of the lysis module). Only a single Mu-like candidate prophage and no clear P2-like prophages were identified in Negativicutes, both commonly found in Proteobacteria. Therefore, it is unlikely that Negativicute phages were acquired from Proteobacteria. Sequence-related prophages were identified in two distinct Negativicute orders (Veillonellales and Acidaminococcales) possibly suggesting horizontal cross-order phage infection between human gut commensals. Phages infecting these Negativicute orders occasionally harboured putative antibiotic resistance genes.
Differential Metabolic Sensitivity of Insulin-like-response- and mTORC1-Dependent Overgrowth in Drosophila Fat Cells
Authors: Devilliers Maelle , Garrido Damien , Poidevin Mickael , Rubin Thomas , Le Rouzic Arnaud , Montagne Jacques 
Published: April 2019

ABSTRACTThe glycolytic/lipogenic axis promotes the synthesis of energetic molecules and building blocks necessary to support cell growth, although the absolute requirement of this metabolic axis must be deeply investigated. Here, we used Drosophila genetics and focus on the mTOR signaling network that controls cell growth and homeostasis. mTOR is present in two distinct complexes, mTORC1 and mTORC2. The former directly responds to amino acids and energetic levels, whereas the latter is required to sustain the signaling response downstream of insulin-like-peptide (Ilp) stimulation. Either signaling branch can be independently modulated in most Drosophila tissues. We confirm this independency in the fat tissue. We show that ubiquitous over-activation of mTORC1 or Ilp signaling affects carbohydrate and lipid metabolism, supporting the use of Drosophila as a powerful model to study the link between growth and metabolism. We show that cell-autonomous restriction of glycolysis or lipogenesis in fat cells impedes overgrowth dependent on Ilp-but not mTORC1-signaling. Additionally, ubiquitous deficiency of lipogenesis (FASN mutants) results in a drop in mTORC1 but not Ilp signaling, whereas, at the cell-autonomous level, lipogenesis deficiency affects none of these signals in fat cells. These findings thus, reveal differential metabolic sensitivity of mTORC1- and Ilp-dependent overgrowth. Furthermore, they suggest that local metabolic defects may elicit compensatory pathways between neighboring cells, whereas enzyme knockdown in the whole organism results in animal death. Importantly, our study weakens the use of single inhibitors to fight mTOR-related diseases and strengthens the use of drug combination and selective tissue-targeting.
Processes of hybridization and de-hybridization: organizing and the task at hand
Authors: Kastberg Gustaf , Lagström Cristian 
Published: April 2019

Purpose
The problematization indicates the need for enhancing the understanding of hybrid settings as potentially dynamic, changing and fragile. The purpose of this paper is to generate the knowledge through a conceptualization of the relationship between hybrid organizing and object, helping us understand how and why hybridization takes place or de-hybridizing occurs.

Design/methodology/approach
The study is based on a longitudinal qualitative case study of an attempt to introduce cost-benefit calculations as a management initiative in the social sector. In total, 18 observations of meetings and 48 interviews were done.

Findings
The main contribution is the empirically detailed description of how hybridizing must be understood in connection to a complex task at hand. A core observation is how complexity is escaped by either an intensive framing or compartmentalization – the former either leading to a disciplined hybrid allowing efficient action or to a hot and contested situation characterized by inertia. The latter, compartmentalization, presupposes less complexity with the potential of full de-hybridization into single-purpose organizing, failing to deal with the complex task at hand.

Research limitations/implications
A limitation is the one case approach and further research could focus on other settings.

Practical implications
The paper provides concepts useful for analysis of specific cooperative arrangements.

Social implications
The authors believe that the findings can bring useful insights to professionals, policy makers and others who are engaging in and addressing complex societal issues, not least within the public sector, a matter all too often overlooked by the accounting research community.

Originality/value
The originality of the paper is the focus on the organization and control in relation to the task at hand.
A sustainable perspective in wine production for common-good management
Authors: Cantino Valter , Giacosa Elisa , Cortese Damiano 
Published: April 2019

Purpose
The purpose of this paper is to analyse how sustainability is crucial in maintaining and assigning value to a common good. In particular, the paper identifies several characteristics of a business model that could be adopted to manage sustainable innovation strategies that respect the balance among environmental, social and commercial goals.

Design/methodology/approach
This case study involves Fontanafredda, an internationally recognised historical Italian wine company characterised by its highly innovative business approach and sustainable business model.

Findings
Fontanafredda’s approach is connected to the broader concept of the common good the winery has internalised to become an element of its competitive advantage and differentiation. The preservation of traditional values – primarily the respect and valuing of one’s own territory – is a key asset of the winery, which attaches great symbolic and concrete importance to these values.

Research limitations/implications
The study uses a single case study approach and a qualitative method without quantifying the impact of every business choice. For theoretical implications, the study emphasises the strong connection between sustainability and innovation in the management of the common good.

Practical implications
Numerous practical implications are identified regarding several stakeholder groups, such as the management, owners, investors and the various entities linked to the regional promotion and tourism sectors.

Originality/value
This research explores how and why Fontanafredda amounts to more than simply wine production by focusing on the characteristics of its business model, which efficiently handles the link between innovation and heritage for common-good development.
Computational fluid dynamics and laminar heat transfer of water/Cu nanofluid in ribbed microchannel with a two-phase approach
Authors: Cheloii Navid Ahmadi , Akbari Omid Ali , Toghraie Davood 
Published: April 2019

Purpose
This study aims to numerically investigate the heat transfer and laminar forced and two-phase flow of Water/Cu nanofluid in a rectangular microchannel with oblique ribs with angle of attacks equal to 0-45°. This simulation was conducted in the range of Reynolds numbers of 5-120 in volume fractions of 0, 2 and 4 per cent of solid nanoparticles in three-dimensional space.

Design/methodology/approach
This study investigates the effect of the changes of angle of attack of rectangular rib on heat transfer and hydrodynamics of two-phase flow. This study was done in three-dimensional space and simulation was done with finite volume method. SIMPLEC algorithm and second-order discretization of equations were used to increase the accuracy of results. The usage of nanofluid, application of rips with different angles of attacks and using the two-phase mixture method is the distinction of this paper compared with other studies.

Findings
The results of this research revealed that the changing angle of attack of ribs is an effective factor in heat transfer enhancement. On the other hand, the existence of rib on the internal surfaces of a microchannel increases friction coefficient. By increasing the volume fraction of nanoparticles, due to the augmentation of fluid density and viscosity, the pressure drop increases significantly. For all of the angle of attacks studied in this paper, the maximum rate of performance evaluation criterion has been obtained in Reynolds number of 30 and the minimum amount of performance evaluation criterion was been obtained in Reynolds numbers of 5 and 120.

Originality/value
Many studies have been done in the field of heat transfer in ribbed microchannel. In this paper, the laminar flow in the ribbed microchannel Water/Cu nanofluid in a rectangular microchannel by using two-phase mixture method is numerically investigated with different volume fractions (0-4 per cent), Reynolds numbers (5-120) and angle of attacks of rectangular rib in the indented microchannel (0-45°).
A cross-level analysis of management commitment and work ability among senior casino dealers in Macau
Authors: Li Jun (Justin) , Kim Jong-Hyeong 
Published: April 2019

PurposeThis paper aims to investigate the corporate-level determinants (i.e. management commitment) of work ability. It also examined whether mid-level contextual variables intensify the relationship between management commitment and the work ability of senior casino dealers.Design/methodology/approachA three-level hierarchical analysis of data from 432 casino dealers from 16 casinos was performed to determine the proportion of variance in the dependent variable when the explanatory variables were at varying hierarchical levels.FindingsThe findings suggest that management commitment has a positive and significant impact on frontline dealers’ work ability. Furthermore, supervisor support and group trust have moderating effects on the relationship between management commitment and dealers’ work ability.Research limitations/implicationsThe current study provides important information on how to increase the ability of aging dealer to remain active and learn new skills.Originality/valueWork ability has received substantial attention from recent studies of human resources because of its close relationship to employee job skills and competencies. However, to the best of the authors’ knowledge, no conceptual model explains the role of work ability role in promoting and updating human resources management practices and policies.
Heterogeneous adoption of quality standards in the hotel industry: drivers and effects
Authors: Tarí Juan José , Pereira-Moliner Jorge , Molina-Azorín José F. , López-Gamero María D. 
Published: April 2019

Purpose
This paper aims to examine the impact of external and internal drivers on the dimensions of internalization (daily practices and continuous improvement) of quality standards, the relationship between the dimensions of internalization and their effects on customer, employee, society and organizational results in hotels.

Design/methodology/approach
The study applies a structural equations analysis to test these relationships using empirical data from 176 quality-certified hotels.

Findings
Hotels need internal drivers to internalize a quality system because the external drivers themselves are not able to explain significantly the quality internalization process. This paper shows the significant relationship between the dimensions of internalization (daily practices and continuous improvement) and the importance of continuous improvement (e.g. innovations from quality standards and reflection on how to improve the current work processes) for improved customer, employees, society and organizational results.

Originality/value
To the best of the authors’ knowledge, there are no empirical studies jointly analyzing the drivers of internalization, the relationship between the dimensions of internalization and their effects on different dimensions of results (customers, employees and society) in hotels.
Model risk regarding monthly wind energy production for the valuation of a wind farm investment
Authors: Krömer Sarah 
Published: April 2019

Purpose
The purpose of this paper is to assess model risk with regard to wind energy output in monthly cash flow models for the purpose of valuation and risk assessment of wind farm investments, where only a few approaches exist in the literature.

Design/methodology/approach
This paper focuses on the risk-return characteristics of this investment from the perspective of private and institutional investors and takes into account several risks, in particular the resource risk related to the uncertainty of the monthly wind energy produced. To this end, this paper presents different approaches for modeling monthly wind power output and assesses the impact of three selected models with different properties on the investment’s risk-return characteristics by means of a stochastic discounted cash flow model. In addition, the model considers the possibility of a joint operation of the wind farm with a pumped hydro storage system to reduce risk and improve profits.

Findings
The results show that the (non-)consideration of seasonality of the monthly wind energy produced considerably influences the risk-return characteristics, but that principal developments dependent on input parameters and model variables remain similar.

Originality/value
This paper contributes to the literature by presenting different approaches for modeling the monthly wind energy produced based on direct models of the wind energy output, which are rare in the existing literature. Further, their impact on risk-return characteristics of a wind farm investment is analyzed, and thus, related model risk is assessed.
Towards a “branded” property developer: key traits for Malaysian housing market
Authors: Yap Jeffrey Boon Hui , Tan Chin Weng , Loo Siaw Chuing , Lee Wah Peng 
Published: April 2019

Purpose
The purpose of this paper is to determine the significance of branding management by property developers in the Malaysian housing market and to examine the pivotal brand identity traits of property developers.

Design/methodology/approach
An explanatory sequential mixed-methods research approach was adopted. The quantitative data from the questionnaire survey were subjected to descriptive statistics, and the ranking with category of significance of the hypothesised branding traits was determined using relative importance index technique. The findings were further validated through semi-structured interviews with five experienced industry practitioners.

Findings
Results showed that the extremely significant (ES) branding identities are value for future investment and location, while the very significant (VS) traits are quality assurance, near to supporting infrastructure, reliability, professionalism, experience, warranties and technical ability. Industry experts affirmed the prospect of exploiting branding in enticing property buyers.

Research limitations/implications
It is reasonable to infer that good branding positively stimulates buyer’s decision-making on purchasing residential property. This study attempts to discover the critical brand identity traits for property developers apt in the context of Malaysian housing market.

Practical implications
Apart from the archetypal locational and financial factors, the findings suggested that top developers should emphasise innovative family-oriented design with an acceptable level of quality score for brand differentiation to further enhance the future value of their end products.

Originality/value
The efficacy of brand management in the housing market has not yet been fully explored in research. This paper is expected to offer more profound insights into the strategic brand management towards “branded” property developers in the context of Malaysia and perhaps other countries with comparable backgrounds.
Social undermining in academia: experiences and effects
Authors: Sabeen Zara , Arshad Faria 
Published: April 2019

PurposeThe purpose of the paper is to explore the meanings and effects of social undermining as described by the faculty members of public and private universities of Pakistan.Design/methodology/approachThe study utilizes the qualitative approach using in-depth interviews of the faculty members to explore different meanings assigned to social undermining and the impact of these experiences on them.FindingsThe faculty members describe social undermining in terms of defamation and limiting of space for them at workplace. The impact of social undermining is directly felt on the emotional and overall well-being. It also affects the work performance of the faculty leading to behaviors like withdrawal and abstaining from voluntary activities.Research limitations/implicationsThe research is conducted in only two universities in the capital city. The experiences and views of faculty members in other universities particularly in small cities might be different.Practical implicationsThe study may be of help in terms of finding out the impacts of social undermining on faculty members in order to avoid such situations, hence, improving the motivation level of faculty. This will help managers to understand the phenomenon and find out appropriate strategies for a more harmonious and trustable work environment between people.Originality/valueThe study contributes to the literature by utilizing the qualitative approach that is not used much in this subject area. It is also one of the very first attempts of exploring the phenomenon in Pakistan, as per the best of authors’ knowledge.
Strategic performance measurement system,firm capabilities andcustomer-focused strategy
Authors: Yuliansyah Yuliansyah , Khan Ashfaq Ahmad , Fadhilah Arief 
Published: April 2019

Purpose
The impact of a firm’s strategic performance measurement system (SPMS) on its customer-focused strategy, under varying contexts, has largely been documented in the literature. However, the system’s capacity to positively influence the firm strategy through its impact on the firm’s peculiar internal and external capabilities, in the peculiar context of the developing countries’ financial services sector, has so far skipped a thorough academic enquiry. This study, using Indonesia’ financial services sector as its ‘site’, aims to fill this void in the literature.

Design/methodology/approach
The authors gleaned the study’s empirical data from financial services sector firms using survey questionnaire and analyzed it using SmartPLS. A total of 107 valid responses from management members of different financial services sector firms in Indonesia were deemed useable.

Findings
The study findings support the paper’s main thesis. The findings revealed that the strategic PMS contributes to enhancing firms’ market orientation and robustness by positively contributing to their customer-focused strategy from three distinct dimensions – competitors, customers and organizational learning.

Research limitations/implications
The authors posit that an effective customer-focused strategy can be accomplished by purposefully adapting the focus of the firm’s strategic PMS to positively influence the organizational learning, which subsequently translates into the firm’s high competitiveness in the marketplace.

Originality/value
The unexplored link between the SPMS, firm’s internal and external capabilities and customer-focused strategy in the particular context of a developing country’s financial services sector will not only fill the current void in the literature but also instigate a new academic debate. The study will also contribute to the management accounting practice in service firms in the developing countries context.
Patterns of cognitive strategy use common in children with reduced social competence derived from parent perceptions
Authors: Challita Julianne , Chapparo Christine , Hinitt Joanne , Heard Robert 
Published: April 2019

IntroductionOccupational therapists are increasingly being referred children who experience reduced social competence. Ineffective use of cognitive strategies during social interactions is known to contribute to reduced social competence in children who have difficulty learning. Little is known about the nature of social cognitive strategy use or how it may be observed in children during performance of school occupations. This study aimed to explore the type of difficulties in cognitive strategy use that children experience during performance of social tasks as perceived by their parents.MethodsA retrospective chart review was used to analyse 306PRPP@HOME(Primary) Parent/Caregiver Questionnaire responses targeting parent perceptions of their child's cognitive strategy use during social interactions. The children were in the first four years of formal schooling and identified by their teachers as having difficulties with social skills. Factor analysis was used to discover conceptual groupings amongst cognitive strategy use items.ResultsFour factors emerged from the analysis. Factor One groupedPRPPcognitive strategy items related to organised thinking, attention and processing external sensory details during social performance. Factor Two grouped items related to higher level thinking for internal self‐evaluation of behaviour. Factor Three grouped items related to focused and dual attention during social interactions. Factor Four grouped items related to performance and adjustment of behaviour to match the context of social interaction.ConclusionParent perceptions indicate that children with reduced social competence experience inefficient use of cognitive strategies which organise attention, sensory perception and planning. This information can be used to specifically target programs which better support the thinking strategies which facilitate children's participation during social activities at school.