bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYSIS OF THE EXPRESSION OF FAS/CD95 AND HSP70 IN LOW AND HIGH GRADE UROTHELIAL CELL CARCINOMA OF THE BLADDER
Authors: Heryanto Heryanto , Kusumastuti Etty Hary , Rahaju Anny Setijo 
Published: February 2018

Urothelial Cell Carcinoma (UCC), also called transitional cell carcinoma of the bladder, is the most common malignancy in urinary tract. The prognosis of this disease is highly dependent on the histological grading at diagnosis. Fas/CD95 has a role in apoptotic process, whereas HSP70 has an antiapoptotic role. This study aimed to analyze the expression of Fas/CD95 and HSP70 in low grade and high grade urothelial cell carcinoma in the bladder. This was an analytic observational study with cross sectional approach. Population and sample were paraffin blocks of urothelial cell carcinoma in the Laboratory of Anatomic Pathology, Dr. Soetomo Hospital, Surabaya in the period of January 2011-December 2016. Each grading of urothelial cell carcinoma was randomly sampled. Immunohistochemystry with Fas/CD95 and HSP70 were performed. Expression of Fas/CD95 and HSP70 were assessed semiquantitatively. Expression of Fas/CD95 and HSP70 were analyzed using Mann-Whitney test and Spearman test. The results showed there was significant different in expression of Fas/CD95 and HSP70 in low and high grades in urothelial cell carcinoma. There was no significant correlation between the expression of Fas/CD95 and HSP70 in urothelial cell carcinoma. As a conclusion, the role of CD95 and HSP70 expression can be useful as marker for the diagnosis, especially in the determination of the grade of differentiation.
Neoisoliquiritigenin Inhibits Tumor Progression by Targeting GRP78-β- catenin Signaling in Breast Cancer
Authors: Tang Hailin , Peng Fu , Huang Xiaojia , Xie Xinhua , Chen Bo , Shen Jiangang , Gao Fei , You Jieshu , Xie Xiaoming , Chen Jianping 
Published: February 2018

Background:
Breast cancer mortality has been stable or decreasing in the world, its incidence
and recurrence rates have sharply risen worldwide in the recent years.

Objective:
To investigate the clinicopathological significance and potential function of GRP78 in the
development and progression of breast cancer. To explore the effects of neoisoliquiritigenin (NISL)
in breast cancer and the underlying mechanism.

Method:
GRP78 was detected by immunohistochemistry (IHC) using breast cancer tissue microarrays
(TMAs), and the association between GRP78 levels and clinicopathological factors and prognosis
was analyzed. The functional effects of GRP78 on breast cancer were validated by an MTT
assay, foci formation assay, Matrigel invasion assay and mouse xenograft assay. The effects of
NISL were tested by an MTT assay, apoptosis assay and mouse xenograft assay. A LigandFit algorithm,
ATPase activity assay, western blot and IHC assay were used to discover the underlying
mechanism of the effects of NSIL.

Results:
GRP78 was highly expressed in breast cancer cell lines and tissues. In addition, high expression
of GRP78 was correlated to poor outcomes and distant metastasis. Functional experiments
showed that GRP78 promoted breast cancer proliferation and invasion in vitro and in vivo. NISL inhibited
cell proliferation and induced cell apoptosis in breast cancer by directly binding to GRP78 to
regulate the β-catenin pathway.

Conclusion:
Taken together, these results highlighted the significance of GRP78 in breast cancer
development and suggested NISL as a natural candidate to inhibit breast cancer by targeting GRP78
and β-catenin signaling.
Active Aging and Elderly’s Quality of Life: Comparing the Impact on Literature of Projects Funded by the European Union and USA
Authors: Kirilov I , Atzeni M , Perra A , Moro D , Carta MG 
Published: February 2018

Background:
The objective of this research is to verify whether European projects on Active Aging (AA) and Elderly Quality of Life (Qol) funded by the Seventh Framework Programme (FP7) produce an impact on literature similar to projects funded by the National Health Institute (NHI) of the United States on international literature using well-known bibliometric indicators. This effort may be useful in developing standardized and replicable procedures.

Methods:
Fifteen randomly selected projects on AA and Elderly Qol concluded in August 2017 and funded by FP7 were compared to similar projects funded by the US NHI with reference to papers published (Scopus and Scholar), papers published in Q1 journals, and the number of citations of the papers linked to the projects.

Results:
In all the indicators considered, the European projects showed no difference with the US NHI projects.

Conclusions:
The EU-funded AA and Qol Elderly projects have an impact on scientific literature comparable to projects funded in the United States by the NHI Agency.
Our results are consistent with the data on general medical research, which indicates that, European research remains at a high level of competitiveness.
In this experimental study, our methodology appeared to be convincing and reliable and it could be applied to the extent of the impact of more extensive research areas.
Our research did not evaluate the relationship between funding required by research and scientific productivity.
PERAN SELF-AWARENESS DAN EGO SUPPORT TERHADAP KEPUASAN HIDUP REMAJA TIONGHOA
Authors: Dariyo Agoes 
Published: February 2018

The objective of this study was to investigate the impact of the self-awareness and
ego support on the life satisfaction of adolescence. Participants were 223
subjects (19-21 years). Collecting data by using questionnaires such as: selfawareness,
ego support, and the life satisfaction of adolescence. Data was
analyzed with multiple regression via SPSS 16.0 software program. Found was
the impact of self-awareness on life satisfaction (r2 = .052, t = 3.467 , p = .001
< .01), the impact of ego support on life satisfaction (r2 = 0,219, t = 7.877, p =
0,000 < 0,01), and the impact of self-awareness and ego support on the life
satisfaction of adolescence (r2 = 0,.243, F = 35.307, p =0, .000 < 0,01).
Pragmatically Applied Cervical and Thoracic Nonthrust Manipulation Versus Thrust Manipulation for Patients With Mechanical Neck Pain: A Multicenter Randomized Clinical Trial
Authors: Griswold David , Learman Ken , Kolber Morey J. , O'Halloran Bryan , Cleland Joshua A. 
Published: February 2018

Study Design Randomized clinical trial. Background The comparative effectiveness between nonthrust manipulation (NTM) and thrust manipulation (TM) for mechanical neck pain has been investigated, with inconsistent results. Objective To compare the clinical effectiveness of concordant cervical and thoracic NTM and TM for patients with mechanical neck pain. Methods The Neck Disability Index (NDI) was the primary outcome. Secondary outcomes included the Patient-Specific Functional Scale (PSFS), numeric pain-rating scale (NPRS), deep cervical flexion endurance (DCF), global rating of change (GROC), number of visits, and duration of care. The covariate was clinical equipoise for intervention. Outcomes were collected at baseline, visit 2, and discharge. Patients were randomly assigned to receive either NTM or TM directed at the cervical and thoracic spines. Techniques and dosages were selected pragmatically and applied to the most symptomatic level. Two-way mixed-model analyses of covariance were used to assess clinical outcomes at 3 time points. Analyses of covariance were used to assess between-group differences for the GROC, number of visits, and duration of care at discharge. Results One hundred three patients were included in the analyses (NTM, n = 55 and TM, n = 48). The between-group analyses revealed no differences in outcomes on the NDI (P = .67), PSFS (P = .26), NPRS (P = .25), DCF (P = .98), GROC (P = .77), number of visits (P = .21), and duration of care (P = .61) for patients with mechanical neck pain who received either NTM or TM. Conclusion NTM and TM produce equivalent outcomes for patients with mechanical neck pain. The trial was registered with ClinicalTrials.gov (NCT02619500). Level of Evidence Therapy, level 1b. J Orthop Sports Phys Ther 2018;48(3):137–145. Epub 6 Feb 2018. doi:10.2519/jospt.2018.7738
Bazı Yağlık Ayçiçeğİ (Helianthus annuus L.) Genotiplerinin Erzurum Ekolojik Koşullarında Adaptasyon Kabiliyetlerinin Belirlenmesi
Authors: SEFAOĞLU Fırat , Kaya Canan 
Published: February 2018

Bu çalışma, Erzurum ekolojik
koşullarına uygun yağlık ayçiçeği genotiplerinin belirlenmesi amacıyla
yürütülmüştür. Ayçiçeği denemesi 2015 yılında tesadüf blokları deneme desenine
göre 4 tekerrürlü olarak Doğu Anadolu Tarımsal Araştırma Enstitüsü Pasinler
deneme istasyonunda kurulmuştur. Çalışmada 10 farklı yağlık ayçiçeği genotipi
kullanılmıştır. Araştırmada genotiplerin çıkış ve çiçeklenme süresi, bitki
boyu, tabla çapı, bin dane ağırlığı,
tohum verimi, ham yağ oranı ve ham yağ
verimi öğeleri incelenmiştir. Çalışma sonucuna göre, genotipler arasında dane
verimi, yağ oranı, yağ verimi, bin dane ağırlığı, bitki boyu ve tabla çapı
bakımından farklılığı P&lt;0.01 ihtimal sınırında önemli olduğu belirlenmiştir.
En yüksek tohum verimi Bosfora (279,8 kg da-1), en düşük tohum verimi ise Erz 10-3 (146,9 kg da-1), en yüksek ham yağ oranı
08 Tr 003 (% 41,2), en düşük ham yağ oranı ise Erz 10-3 (% 30,5), en yüksek
ham yağ verimi 111,9 kg da-1 ile Bosfora, en düşük ham
yağ verimi ise 44,8 kg da-1
ile Erz 10-3 genotipinden elde edilmiştir
Studi pembesaran tiram (Crassostrea sp) melalui desain tata letak yang berbeda
Authors: Zainura Zainura , Rusydi Rachmawaty , Khalil Munawar 
Published: February 2018

Tiram (Crassostrea sp) merupakan salah satu bivalvial potensial yang dapat dikembangkan dalam rangka meningkatkan pendapatan ekonomi. Tata desain media budidaya tiram yang baik akan mempengaruhi pertumbuhan dan kelangsungan hidup tiram. Penelitian ini bertujuan untuk melihat tata desain media budidaya tiram yang baik sehingga mempengaruhi pertumbuhan dan kelangsungan hidup tiram. Penelitian ini dilaksanakan di Keramba Jaring Apung Loskala Lhokseumawe dan di Laboratorium Hatchery dan Teknologi Reulet Program Studi Budidaya Perairan Fakultas Pertanian Universitas Malikussaleh dari bulan Juni sampai Agustus 2015. Adapun perlakuannya yaitu metode peletakkan benih tiram secara rak (horizontal), gantung (vertikal) dan didasar perairan dengan substrak batuan. Adapun rancangan yang digunakan pada penelitian ini adalah Rancangan Acak Lengkap (RAL) dengan 3 ulangan dan 3 perlakuan dan dilanjutkan dengan uji Beda Nyata Terkecil (BNT) jika terdapat perbedaan. Parameter yang diamati adalah kelangsungan hidup, pertambahan panjang, lebar, ketebalan cangkang, pertambahan bobot dan kualitas air. Pertambahan bobot, lebar, panjang, dan ketebalan cangkang tertinggi terdapat pada perlakuan B yaitu dengan nilai rata-rata sebesar 42,95 gram, 1,331 mm, 1,487 mm, 1,843 mm dan pertambahan bobot, lebar, panjang, dan ketebalan cangkang terendah terdapat pada perlakuan C yaitu 0,00 gram dan 0,00 mm. Rata-rata kelangsungan hidup yaitu 84% pada perlakuan A dan B, 0% pada perlakuan C. parameter kualitas air berada pada kisaran yang baik untuk pertumbuhan tiram dalam kisaran suhu 27 - 30 oC, pH 6,8 – 7,5 , dan DO 4,8 – 7,4 ppm.Oysters (Crassostrea sp) is one of the bivalves that is potential to be developed for improving the economic income. The good layout design for culturing oyster will affect its growth and survival. This study aimed to evaluate the layout design which was good for oyster cultivation affecting the growth and survival of oyster. This research was conducted at floating cage Loskala, Lhokseumawe and in Hatchery and Technology Laboratory, Aquaculture Department, Agriculture Faculty Malikussaleh University fwhich was held on June to August 2015. The treatments were to use rack method (horizontal), hanging (vertical) and bottom methods. Completely randomized design (CRD) was used as research design with three replication for three treatments. Then it was continued by LSD (Least Significant Difference) Test,if there was a difference.Parameters measured were survival length, width, thickness of the shell, weight and water quality.The highest weight, width, length, and thickness of shell were obtained in treatment B which were 42,95 gram; 1,331 mm, 1,487 mm, 1,843 mm. other wise, the lowest one were obtained in treatment C which were 0 gram and 0 mm.The survival rate of both treatment A and B was 89%, which treatment C was 0%. water quality parameters were in good range for growth of oysters where as temperature 27-30 ° C, pH 6,8 to 7,5, and DO 4,8 to 7,4 ppm.
SISTEM PENUNJANG KEPUTUSAN DALAM MENENTUKAN INSENTIF BAGI KARYAWAN MENGGUNAKAN METODE PROMETHEE
Authors: Tri Irawati Aorora Mahardika, Sri Siswanti, 
Published: February 2018

PT. Sami Surya Indah has 7,100 employees who provide incentive issues, in addition to the current handling of obstacles in reporting and determination of employees who deserve incentives. The current system in the Company is still using manual process where the database used is still in paper form. For that will be designed and made a decision support system to determine the incentives for employees with the method Promethee in PT. Sami Surya Indah. The purpose of this study is to design and build systems that can assist in determining the feasibility of providing incentives to prospective employees. This study also aims to apply the Promethee method for determining the feasibility of providing incentives to employees. Methods of data collection include field study and literature study. Field studies include interviews and observations. While the literature study conducted by examining the relevant literature with the problem. Designing system design using CD (Context Diagram), DFD (Data Flow Diagram) and ERD (Entity Relation Diagram), Implementation program with PHP and database MySql. The results of the functionality test shows the application is running in accordance with its function and based on the validity test of the application has been declared valid. In performing system performance testing the author uses Blackbox method. Keywords: Decision Support System, Promethee Method, Incentive Determination
Magnetic Field Transport in Accretion Disks
Authors: Jafari Amir , Vishniac Ethan T. 
Published: February 2018

Abstract
The leading models for launching astrophysical jets rely on strong poloidal magnetic fields threading the central parts of their host accretion disks. Numerical simulations of magneto-rotationally turbulent disks suggest that such fields are actually advected from the environment by the accreting matter rather than generated by internal dynamos. This is puzzling from a theoretical point of view, since the reconnection of the radial field across the midplane should cause an outward drift on timescales much shorter than the accretion time. We suggest that a combination of effects are responsible for reducing the radial field near the midplane, causing efficient inward advection of the poloidal field. Magnetic buoyancy in subsonic turbulence pushes the field lines away from the midplane, decreasing the large-scale radial field in the main body of the disk. In magneto-rotationally driven turbulence, magnetic buoyancy dominates over the effects of turbulent pumping, which works against it, and turbulent diamagnetism, which works with it, in determining the vertical drift of the magnetic field. Balancing buoyancy with diffusion implies that the bending angle of the large-scale poloidal field can be very large near the surface, as required for outflows, but vanishes near the midplane, which impedes turbulent reconnection and outward diffusion. This effect becomes less efficient as the poloidal flux increases. This suggests that accretion disks are less likely to form jets if they have a modest ratio of outer to inner radii or if the ambient field is very weak. The former effect is probably responsible for the scarcity of jets in cataclysmic variable systems.
Galaxy Formation in Sterile Neutrino Dark Matter Models
Authors: Menci N. , Grazian A. , Lamastra A. , Calura F. , Castellano M. , Santini P. 
Published: February 2018

Abstract
We investigate galaxy formation in models with dark matter (DM) constituted by sterile neutrinos. Given their large parameter space, defined by the combinations of sterile neutrino mass

and mixing parameter

with active neutrinos, we focus on models with

, consistent with the tentative 3.5 keV line detected in several X-ray spectra of clusters and galaxies. We consider (1) two resonant production models with

and

, to cover the range of mixing parameters consistent with the 3.5 keV line; (2) two scalar-decay models, representative of the two possible cases characterizing such a scenario: a freeze-in and a freeze-out case. We also consider thermal warm DM with particle mass

. Using a semianalytic model, we compare the predictions for the different DM scenarios with a wide set of observables. We find that comparing the predicted evolution of the stellar mass function, the abundance of satellites of Milky Way–like galaxies, and the global star formation history of galaxies with observations does not allow us to disentangle the effects of the baryonic physics from those related to the different DM models. On the other hand, the distribution of the stellar-to-halo mass ratios, the abundance of faint galaxies in the UV luminosity function at

, and the specific star formation and age distribution of local, low-mass galaxies constitute potential probes for the DM scenarios considered. We discuss how future observations with upcoming facilities will enable us to rule out or to strongly support DM models based on sterile neutrinos.
Dientamoeba fragilis diagnosis by fecal screening: relative effectiveness of traditional techniques and molecular methods
Authors: Hamidi Negin , Meamar Ahmad Reza , Akhlaghi Lameh , Rampisheh Zahra , Razmjou Elham 
Published: February 2018

Introduction: Dientamoeba fragilis, an intestinal trichomonad, occurs in humans with and without gastrointestinal symptoms. Its presence was investigated in individuals referred to Milad Hospital, Tehran.
Methodology: In a cross-sectional study, three time-separated fecal samples were collected from 200 participants from March through June 2011. Specimens were examined using traditional techniques for detecting D. fragilis and other gastrointestinal parasites: direct smear, culture, formalin-ether concentration, and iron-hematoxylin staining. The presence of D. fragilis was determined using PCR assays targeting 5.8S rRNA or small subunit ribosomal RNA.
Results: Dientamoeba fragilis, Blastocystis sp., Giardia lamblia, Entamoeba coli, and Iodamoeba butschlii were detected by one or more traditional and molecular methods, with an overall prevalence of 56.5%. Dientamoeba was not detected by direct smear or formalin-ether concentration but was identified in 1% and 5% of cases by culture and iron-hematoxylin staining, respectively. PCR amplification of SSU rRNA and 5.8S rRNA genes diagnosed D. fragilis in 6% and 13.5%, respectively. Prevalence of D. fragilis was unrelated to participant gender, age, or gastrointestinal symptoms.
Conclusions: This is the first report of molecular assays to screen for D. fragilis in Iran. The frequent finding of D. fragilis via fecal analysis indicated the need to include this parasite in routine stool examination in diagnostic laboratories. As the length of amplification target correlates to the sensitivity of PCR, this assay targeting the D. fragilis 5.8S rRNA gene seems optimal for parasite detection and is recommended in combination with conventional microscopy for diagnosing intestinal parasites.
Increasing the efficiency and productivity in the production of low voltage switchboard using resource constrained project scheduling
Authors: Tannady Hendy , Maimury Yona 
Published: February 2018

Purpose: This research was made with the aim to give a scheduling proposal for the assembly activity and the proposal to allocate those activities into available resources using the resource-constrained project scheduling.Design/methodology/approach: The research begins with the problem exposition in the existing system on the Assembly Department of panel manufacturer company. To overcome the problem, several scheduling alternatives are formulated to yield better productivity. The performance of proposed system using RCPS is assessed using simulation method. Considering the circumstance of demand rate, the scenarios chosen are based on the parameter such as product departure cycle time, resource utilization, product ouput, and number of resource required.Findings: The scheduling alternatives provides the better arrangement of work elements in the assembly activity, especially for the product that represent the highest demand rate. For further research, the paper gives encouragement so that the application of RCPS can be used broader in the manufacturing area.Research limitations/implications: Although the findings was addressed to improve the existing system on the Assembly Department, the practical application haven’t been undergone and the performance assessment only based on the simulation method.Practical implications: By implementing the proposed scheduling, the company will experience several benefits. First, the company could increase its productivity by better utilization of its resources. Second, based on the simulation result, the company could avoid the backorder option while dealing with the high demand rate, and even can fully maximize its resource utilization without adding more worker or apply the overtime policy. Finally, the proposed scheduling that converted into the work instruction could help the company to perform the knowledge transfer from the existing worker or resigned worker to the newly-hired worker.Originality/value: The outcome of the research could become the guidance for other companies which have similar assembly system to apply the same method. This is the best paper that represents the application of RCPS in the large-sized component assemblies, where the walking worker is responsible for carrying tasks to each unmoved unit.
Precision 4D Printing of Multifunctional Olive Oil‐Based Acrylate Photo‐resin for Biomedical Applications
Authors: Ghosal Krishanu , Rashed Nagham , Khamaisi Bassma , Farah Shady 
Published: October 2024

AbstractSince the advent of 3D printing technology, a significant effort has been made to develop new 3D printable materials. Despite the recent progress in the field of 3D printing, the limited availability of photoactive resins has motivated continuous research endeavors to develop novel photoresins with multifunctional capabilities. Herein a biobased photoresin derived is reported from modified olive oil, designed for high‐resolution solvent‐free 4D printing with multifunctional capabilities. The physicochemical properties of the printed polymers are fine‐tuned using acrylic acid as a diluent cum comonomer. The mechanical properties of the printed polymers are similar to various soft tissues, such as ligaments, articular cartilage, and soft collagenous bone, showcasing its potential for soft tissue engineering applications. While the excellent temperature‐responsive shape memory 4D attributes coupled with exceptional antimicrobial properties toward gram‐negative and gram‐positive bacteria highlight the multifunctional nature of the printed polymers. Moreover, the printed polymers exhibited outstanding hemocompatibility and good cytocompatibility toward mouse fibroblast cells, suggesting their potential soft tissue engineering applications. In sum, the newly developed biobased resin can be employed to minimize the environmental impact of additive manufacturing while being competitive with existing fossil‐based photoresins, thereby meeting the growing demand for advanced photoresins with superior high‐resolution printing and smart properties for biomedical applications.