bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enzyme replacement therapy for mucopolysaccharidosis VI: Growth	and pubertal development in patients treated with recombinant human N-acetylgalactosamine 4-sulfatase
Authors: Decker Celeste , Yu Zi-Fan , Giugliani Roberto , Schwartz Ida Vanessa D. , Guffon Nathalie , Teles Elisa Leão , Miranda M. Clara Sá , Wraith J. Edmond , Beck Michael , Arash Laila , Scarpa Maurizio , Ketteridge David , Hopwood John J. , Plecko Barbara , Steiner Robert , Whitley Chester B. , Kaplan Paige , Swiedler Stuart J. , Conrad Susan , Paul Harmatz for the MPS VI Study Group  
Published: December 2024

Background and Methods: Growth failure is characteristic of untreated mucopolysaccharidosis type VI (MPS VI: Maroteaux-Lamy syndrome). Growth was studied in fifty-six MPS VI patients (5 to 29 years old) prior to and for up to 240 weeks of weekly infusions of recombinant human arylsulfatase B (rhASB) at 1 mg/kg during Phase 1/2, Phase 2, Phase 3 or Phase 3 Extension clinical trials. Height, weight, and Tanner stage data were collected. Pooled data were analyzed to determine mean height increase by treatment week, growth impacts of pubertal status, baseline urinary GAG, and age at treatment initiation. Growth rate for approximately 2 years prior to and following treatment initiation was analyzed using longitudinal modeling. Results: Mean height increased by 2.9 cm after 48 weeks and 4.3 cm after 96 weeks on enzyme replacement therapy (ERT). Growth on ERT was not correlated with baseline urinary GAG. Patients under 16~years of age showed greatest increases in height on treatment. Model results based on pooled data showed significant improvement in growth rate during 96~weeks of ERT when compared to the equivalent pretreatment time period. Delayed pubertal onset or progression was noted in 10 patients entering the clinical trials; all of whom showed progression of at least one Tanner stage during 2 years on ERT, and 6 of whom (60%) completed puberty. Conclusion: Analysis of mean height by treatment week and longitudinal modeling demonstrate significant increase in height and growth rate in MPS VI patients receiving long-term ERT. This impact was greatest in patients aged below 16 years. Height increase may result from bone growth and/or reduction in joint contractures. Bone growth and resolution of delayed puberty may be related to improvements in general health, bone cell health, nutrition, endocrine gland function and reduced inflammation.
The effects of backpack load carrying on dynamic balance as	measured by limits of stability
Authors: Palumbo Nicole , George Brad , Johnson Amanda , Cade Dennis 
Published: December 2024

{\it Purpose:} The purpose of this research was to determine if standing dynamic balance was affected by carrying a backpack. {\it Subjects:} Data was obtained from 50 healthy college students. {\it Materials and methods:} Limits of stability was assessed using the Smart Equitest Balance Master System(R). Reaction time, movement velocity, end point excursion, maximum excursion, and directional control were measured to evaluate movement, with and without a loaded backpack. {\it Data analysis:} Reliability was established using an Intra-Class Correlation Coefficient (2,1). MANOVA was utilized to analyze the effect of the backpack. {\it Summary data:} Movement velocity significantly decreased during backpack loaded trials ( $p=0.004$ ). Directional control was significantly different with respect to direction ( $p=0.006$ ). No significant difference in reaction time, maximum excursion, or end point excursion was observed with backpack loading ( $p=0.10-0.93$ ). {\it Conclusion:} This study concludes that backpack load carrying has an effect on movement velocity and directional control.
Work hardening: Outdated fad or effective intervention?
Authors: Johnson Leslie Stratton , Archer-Heese Gail , Caron-Powles Deanne L. , Dowson Tracey M. 
Published: December 2024

{\it Objectives}: The purpose of this outcome measurement study was to determine the effectiveness of a work hardening program as measured by the participants' work status at three months after program completion. Predictors of successful return to work were explored. {\it Study design}: The sequential case series design was employed, and data were gathered at three points: the initial work hardening assessment, the discharge assessment, and three months post-discharge from the work hardening program. Seventy-nine participants were included. {\it Results}: Eighty-two percent (82%) of the clients who completed a work hardening program reported that they were working in some capacity three months after program completion. They listed their employment status in 5 sub-categories. Significant predictors of employment included ``single'' marital status, lower perceived disability scores at program entry, reduction in reported pain during program duration, and funding source. {\it Conclusion}: Work hardening remains an effective treatment strategy which promotes successful return to the workplace. Ongoing analyses of these programs is imperative.
Experience of musculo-skeletal disorders, intensity of pain, and	general conditions in work -- The case of employees in non-private dental	clinics in a county in southern Sweden
Authors: Rolander Bo , Bellner Anna-Lena 
Published: December 2024

{\it Objectives:} (1) To identify perceived musculo-skeletal disorders and intensity of pain among the employees in the non-private dental clinics; (2) To assess perceived psychosocial and physical work conditions on the localization and intensity of musculo-skeletal disorders and pain. {\it Study design:} A questionnaire, comprising four sections (demographic, self-reported psychosocial and physical work conditions, self-reported disorders from the musculo-skeletal system, self-reported intensity of pain on nine different localization on the body) was mailed to 391 employees. Of these, 338 reported musculo-skeletal disorders. In this latter group, 239 reported work as the cause. These employees completed the questionnaire. {\it Results:} The greatest amount of pain was reported for the cervico-brachial region. Among all participants, a response pattern was found where the physical work demands were very high, the psychosocial work demands fairly high, the work climate supportive, and the control over work moderate. At an occupational group level, theoretical inconsistencies were identified in terms of a lack of anticipated relationships, especially for the dentist groups. {\it Conclusions:} For a scientific and social purpose, more research, which identifies relationships between work-related musculo-skeletal pain and dos-response [8], effort-reward [16], and demand-control [12] aspects of the working conditions, is clearly needed.
Attributes of excellence in work-related assessments
Authors: Innes Ev , Straker Leon 
Published: December 2024

In order for clinicians to select and conduct work-related assessments that demonstrate 'best practice', it is necessary to identify assessments that are considered 'excellent'. Objectives: The aims of this study were to determine (1) the attributes associated with excellence for each of 3 types of work-related assessment (WPAs, FCEJs & FCENJs), and (2) the differences between the attributes associated with each type of work-related assessment. Study design: A questionnaire was sent to all accredited occupational or vocational rehabilitation providers in Australia, targeting occupational therapists and physiotherapists who conducted work-related assessments. The response rate was 25.3%, and 132 questionnaires were analysed. Results: A MANOVA revealed that the perceived importance of 18 attributes was different between the 3 forms of work-related assessment $F_{36, 364}=6.54$ ; p<0.001). There was a core of 7 attributes that showed no difference between assessments (accurate, compr ehensive, credible, flexible, practical, safe and useful). Two attributes (generalisable and specific) were different for all 3 forms of assessment. A large group of attributes (consistent, measurable, objective, reliable, reproducible, standardised, structured and valid) demonstrated significant differences between WPAs and both forms of FCE. Relevant demonstrated significant differences between FCENJs and both WPAs and FCEJs. Reliability analysis revealed 2 constructs (dependability and utility). Conclusions: This study demonstrated that there were significant differences between 3 forms of work-related assessments (WPAs, FCEJs & FCENJs) in terms of the attributes considered necessary for excellence for each form of assessment. The attributes were considered to relate to either qualitative or quantitative features of assessment. These features were reflected in the constructs utility, which was comprised of qualitative attributes and associated with broad concepts of validity, and dependability, which was comprised of quantitative attributes and reflected concepts of reliability. There appeared to be a continuum of work-related assessment that ranged from WPAs demonstrating the most qualitative attributes to FCENJs demonstrating the most quantitative features.
Individual status at the start of rehabilitation: Implications for	vocational rehabilitation programs
Authors: Millet Patrick , Sandberg Karl W. 
Published: December 2024

This research investigated the situation of 143 unemployed sick leavers at the start of vocational rehabilitation in Sweden. It is argued in this paper that in order to gain a meaningful picture of the vocational rehabilitation process it is necessary to know and understand something of individual differences and status at the onset. In doing so, assessment was carried out of the possible influence of one contextual factor and five individual factors on health, duration of sick leave and unemployment. Findings suggest that individual differences exist in health status, length of sick leave and unemployment, at the upstart of vocational rehabilitating. Locus of control was found to exert important influence on the differences between the individuals in the study sample, with persons of external locus of control having a less favourable point of departure at the start of vocational rehabilitation compared to other groups. It is therefore assumed that these persons will be in greater need of support during the vocational rehabilitation process. The level of unemployment within a geographical area was also found to influence the length of sick leave. Conclusions: Our suggestion is for rehabilitation programs to be developed and selected to match the special needs and differences whether they are of individual or of social nature.
Use of Dictionary of Occupational Titles (DOT) on formwork	carpentry – A comparison between the United States and Hong Kong
Authors: Lee Gloria K.L. , Chan Chetwyn C.H. 
Published: December 2024

Objectives: This study aimed at investigating the utilization and applicability of the Dictionary of Occupational Titles (DOT) as a methodology to study the job profile (nature and physical demand) of formwork carpentry in the local situation. Study design: Thirty male formwork carpenters were recruited by convenient sampling to participate in a two-hour interview, with reference to the DOT Physical Demand Questionnaire (DOTPDQ) and the WestTool Sort Questionnaire. The information obtained was further consolidated by comparing the results from the interview to three construction sites and training guidelines from the formwork carpentry training centers. The triangulation of the data formulated a job profile of formwork carpenters. Results: The results from the DOTPDQ revealed that workers' work demands were standing, walking, pushing, pulling, reaching, climbing, balancing, stooping, crouching, lifting, carrying, handling and near acuity. This produced an agreement of 84.6% with the original DOT. A discrepancy was found in the demands of kneeling, fingering, far acuity and depth perception. Conclusions: The discrepancy between the data from the United States and local appeared to be minimal. It was thus inferred that the DOT-based job profile was largely valid for describing formwork carpentry in Hong Kong. In-depth analysis should be conducted to further substantiate the validity of utilizing the DOT system for other job types and their physical demands.
A pilot study evaluating a peer led and professional led physical	activity intervention with blue-collar employees
Authors: Elbel Russ , Aldana Steve , Bloswick Don , Lyon Joseph L. 
Published: December 2024

Objective: To measure the effect of a physical activity intervention, based on social cognitive theory, delivered by a peer and a professional leader. Design: Quasi-experimental. Setting: Three locations at a large Mid-Western railroad. Subjects: One hundred and forty-eight skilled labor employees participated: one hundred and twenty completed the study. Measures: Self-reported energy expenditure, self-efficacy and stages of change. Results: ANOVA and categorical analysis using rates and proportions were used for evaluation. The peer group had a non-significant short-term increase in energy expenditure of 3%, which returned to baseline post intervention. The professional and control groups showed a non-significant decrease in energy expenditure of 5% and 9%, respectively. The peer (p < 0.002) and professional groups (p < 0.004) showed significant increases in average stages scores. The peer group maintained increases over time (p < 0.001). The peer and professional led groups showed a 54% and 24% increase in the number of employees reporting regular physical activity over time, respectively. The peer group also showed positive trends in self-efficacy. Conclusions: The peer intervention enhanced self-efficacy and self-reported physical activity. A job layoff at the professional led site confounded comparisons between locations. Employees reported high energy expenditure and high BMI values, suggesting that a weight management intervention may be more appropriate and appealing in this population.
The costs of job accommodations for employees with low back	pain
Authors: Halpern Manny 
Published: December 2024

Accommodations are interventions designed to reduce exposure to factors that limit the activities of an impaired individual. The process incurs costs due to job analysis, implementation and follow up. This theoretical paper expands a model of the ergonomic intervention process and provides data on costs of accommodating individuals with musculoskeletal disorders, particularly low back pain. Accommodations begin with evaluation and documentation of exposure to risk factors. The methods depend on the budget and clinical utility of the data. A full hazard analysis may require 1-hour managerial time plus 1-hour employee time per job. Studies by the Department of Labor and others indicate that at least a quarter of problem jobs could be addressed faster and for less than $500. Follow-up incurs variable employee and managerial time; an ergonomist may be required in 15% of cases. The benefit is expected mainly from reducing compensation costs. Universal solutions could increase the benefits.
The relationship between fishermen's health and sleeping	habits
Authors: Ólafsdóttir Lovísa 
Published: December 2024

This article describes research on fishermen's health and sleeping habits in Iceland. It presents the first findings of the project that were presented in October 2002 at a conference that was organized during Seamen Safety Week in Iceland. It covers physical and mental stress symptoms, sleep disturbance, and obesity, as well as fishermen's own reaction to their health and well-being. Take notice that the findings that are presented in this article can be found in a report presented in August, when the whole study will be finished. Finally, it is concluded how successful the response has been and how the project can be used positively with other studies. It is also noted that, in fact, these findings will be used for further studies linked to safety on board.
Challenges for the older academic in balancing work and	wellness
Authors: Dale Lucinda 
Published: December 2024

Objective: The objective of this study was to describe the risks for the development of MSDs in older academics. Method: Four older academics needed modification of their offices to reduce symptoms of MSDs. In order to improve their occupational performance, data were gathered through interviews and observations, facilitating selection of interventions responsive to their unique client factors, physical contexts, and the organizational environment. Results: Older academics did not perceive risks for the development of MSDs in work that was sedentary. Their routines included few health and wellness behaviors in a culture rewarding excessive work, facilitating commitment to the organization, and understating the importance of health and wellness to the academic community. Conclusions: Occupational therapists must reframe sedentary work as physically demanding and potentially risky for the development of MSDs, and must recognize the organizational influences on the work of academics. Prolonging work life might likely result from modifications in the physical context and from the academic adopting healthy lifestyle routines within multiple environments.
The aging musician
Authors: Barton Rebecca 
Published: December 2024

Objective: Older musicians may develop occupational performance problems resulting from age-related changes and features unique to their occupation. The purpose of this study was to describe the impact of the aging process on an older professional musician. Method: A phenomenological approach was used to study the effects of the aging process on a 71 year old, semi-retired, part-time paid jazz musician. Data were gathered through interviews and observations of performance environments, and analyzed using a grounded hermeneutic approach. An expert panel facilitated theme development. Results: The musician's experiences related to changes in an ability to perform his daily occupations, including music; his response to the external changes in the playing environment and in his relationships with others; and the way in which he has coped with these changes. Conclusion: Occupational therapists who provide intervention for older musicians must implement a client centered approach to care, which provides strategies the musician can use to overcome the challenges related to aging in order to continue professional performance.
Women's work in Guatemala
Authors: Bonder Bette R. , Bazyk Susan , Reilly Bridget , Toyota Jan 
Published: December 2024

Objective: The purpose of this paper is to describe women's work in Maya communities in the Guatemala Highlands, along with some of the trends accompanying the rapid societal change there. Method: Over the course of six years, observations and interviews focused on two specific groups of women. The first were traditional, home-based women, the second, teachers in a primary school. Resulting transcripts and field notes were analyzed by the researchers to identify themes related to the women's perspectives on work, the patterns of their work activities, and the importance of work in their lives. Women who had been interviewed were asked to reflect on the themes identified. Results: All the women engaged in paid work activities and were responsible for obligatory tasks in the home. The traditional group preserved the tradition of weaving, but remained largely illiterate, while the emerging group was literate, but did not learn to weave. Conclusion: Cultural change is both positive and negative, as described by these women. It is important to understand the particular values of the culture, and to recognize that these may not conform to Western (that is to say US.) beliefs and practices.
Well-being and occupational roles among middle-aged women
Authors: Håkansson Carita , Eklund Mona , Lidfeldt Jonas , Nerbrand Christina , Samsioe Göran , Nilsson Peter M. 
Published: December 2024

One purpose of the present study is to explore the stability of the pattern of health/work and sickness absence among middle-aged women over a period of three years. This study tested two hypotheses: (a) that enduringly healthy working women would perceive more valued occupational roles and higher well-being than long-term sick-listed women; (b) that high levels of well-being at baseline would predict enduring health and occupational role value at a 3-year follow-up. Middle-aged women (n = 208) answered a postal survey with the Role checklist, a well-being scale and questions about work and sickness situation. The results showed that there was a considerable variability in the pattern of health/work and sickness absence. The variability was greatest among the women who were long-term sick-listed at baseline, and the internal drop out was great among them. The results showed that the enduringly healthy women experienced a more valued worker role and higher well-being than the long-term sick-listed women. Furthermore, high levels of well-being concerning health and work predicted enduring health in the studied sample, and high well-being concerning work was predictive of a valued worker role. Interventions that enable women to develop valuable worker and leisure roles, as well as harmony between different roles, may be important constituents of health promotion/rehabilitation programmes.
Sickness absence with low-back, shoulder, or neck diagnoses: An	11-year follow-up regarding gender differences in sickness absence and	disability pension
Authors: Alexanderson Kristina A.E. , Borg Karin E. , Hensing Gunnel K.E. 
Published: December 2024

Background: There is very little knowledge on the long-term outcomes of sickness absence. The aim was to investigate sickness absence and disability pensions over 11 years in a cohort of young persons initially long-term sick listed with back, neck, or shoulder diagnoses. Method: A prospective population-based cohort study of all 213 individuals in the Municipality of Linköping, Sweden, who in 1985 were aged 25–34 and had at least one new sick-leave spell > 28 days with such diagnoses. Main results: More women (61%) than men fulfilled the inclusion criteria. In 1996, 22% of the cohort (14% of the men, 26% of the women) had been granted disability pension; 76% of these individuals with musculoskeletal and the rest with psychiatric diagnoses. Partial disability pension was granted to 59% of the women, 17% of the men. Women were more often granted temporary disability pension than men. Conclusions: This proved to be a high-risk group for disability pension. There were large and somewhat unexpected gender differences regarding incidence and type of disability pension. It has been debated how soon physicians should be concerned about the risk of long-term disability regarding these diagnoses; at four or eight weeks of sickness absence – our results support the former, at least for women.