bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete Genomic Sequences of H3N8 Equine Influenza Virus Strains Used as Vaccine Strains in Japan
Authors: Nemoto Manabu , Yamanaka Takashi , Bannai Hiroshi , Tsujimura Koji , Kokado Hiroshi 
Published: March 2018

ABSTRACT
We sequenced the eight segments of influenza A virus strains A/equine/Ibaraki/1/2007 and A/equine/Yokohama/aq13/2010, which are strains of the Florida sublineage clades 1 and 2 of the H3N8 subtype equine influenza virus. These strains have been used as vaccine strains in Japan since 2016 in accordance with World Organization for Animal Health (OIE) recommendations.
Next-Generation Sequencing of Haematococcus lacustris Reveals an Extremely Large 1.35-Megabase Chloroplast Genome
Authors: Bauman Nicholas , Akella Srividya , Hann Elizabeth , Morey Robert , Schwartz Ariel S. , Brown Rob , Richardson Toby H. 
Published: March 2018

ABSTRACT

Haematococcus lacustris
is an industrially relevant microalga that is used for the production of the carotenoid astaxanthin. Here, we report the use of PacBio long-read sequencing to assemble the chloroplast genome of
H. lacustris
strain UTEX:2505. At 1.35 Mb, this is the largest assembled chloroplast of any plant or alga known to date.
Complete Genome Sequences of a Hantavirus Isolate from New York
Authors: McMullan L. K. , Albariño C. G. , Ksiazek T. G. , Nichol S. T. , Spiropoulou C. F. 
Published: March 2018

ABSTRACT

We report here the complete genome sequences for all three segments of the New York hantavirus (New York 1). This is the first reported L segment sequence for hantaviruses maintained in
Peromyscus
spp. endemic to the eastern United States and Canada.
Complete Genome Sequence of Altererythrobacter sp. Strain B11, an Aromatic Monomer-Degrading Bacterium, Isolated from Deep-Sea Sediment under the Seabed off Kashima, Japan
Authors: Maeda Allyn H. , Nishi Shinro , Ishii Shun'ichi , Shimane Yasuhiro , Kobayashi Hideki , Ichikawa Junko , Kurosawa Kanako , Arai Wataru , Takami Hideto , Ohta Yukari 
Published: March 2018

ABSTRACT

Altererythrobacter
sp. strain B11 is an aromatic monomer-degrading bacterium newly isolated from sediment under the seabed off Kashima, Japan, at a depth of 2,100 m. Here, we report the complete nucleotide sequence of the genome of strain B11.
Complete Genome Sequence of Loktanella vestfoldensis Strain SMR4r, a Novel Strain Isolated from a Culture of the Chain-Forming Diatom Skeletonema marinoi
Authors: Töpel Mats , Pinder Matthew I. M. , Johansson Oskar N. , Kourtchenko Olga , Godhe Anna , Clarke Adrian K. 
Published: March 2018

ABSTRACT

We report here the genome sequence of
Loktanella vestfoldensis
strain SMR4r, isolated from the marine diatom
Skeletonema marinoi
strain RO5AC. Its 3,987,360-bp genome consists of a circular chromosome and two circular plasmids, one of which appears to be shared with an
S. marinoi
-associated
Roseovarius
species.
Omphalocele: from diagnosis to growth and development at 2 years of age
Authors: Hijkoop Annelieke , Peters Nina C J , Lechner Rosan L , van Bever Yolande , van Gils-Frijters Annabel P J M , Tibboel Dick , Wijnen René M H , Cohen-Overbeek Titia E , IJsselstijn Hanneke 
Published: March 2018

ObjectivesTo compare the prenatal frame of reference of omphalocele (ie, survival of fetuses) with that after birth (ie, survival of liveborn neonates), and to assess physical growth and neurodevelopment in children with minor or giant omphalocele up to 2 years of age.DesignWe included fetuses and neonates diagnosed in 2000–2012. Physical growth (SD scores, SDS) and mental and motor development at 12 and 24 months were analysed using general linear models, and outcomes were compared with reference norms. Giant omphalocele was defined as defect ≥5 cm, with liver protruding.ResultsWe included 145 fetuses and neonates. Of 126 (87%) who were diagnosed prenatally, 50 (40%) were liveborn and 35 (28%) survived at least 2 years. Nineteen (13%) neonates were diagnosed after birth. Of the 69 liveborn neonates, 52 (75%) survived and 42 children (81% of survivors) were followed longitudinally. At 24 months, mean (95% CI) height and weight SDS were significantly below 0 in both minor (height: −0.57 (−1.05 to –0.09); weight: −0.86 (−1.35 to –0.37)) and giant omphalocele (height: −1.32 (−2.10 to –0.54); weight: −1.58 (−2.37 to –0.79)). Mental development was comparable with reference norms in both groups. Motor function delay was found significantly more often in children with giant omphalocele (82%) than in those with minor omphalocele (21%, P=0.002).ConclusionsThe prenatal and postnatal frames of reference of omphalocele differ considerably; a multidisciplinary approach in parental counselling is recommended. As many children with giant omphalocele had delayed motor development, we recommend close monitoring of these children and early referral to physical therapy.
Non-incisional eyelid everting suture technique for treating lower lid epiblepharon
Authors: Seo Ji Won , Kang Sunah , Ahn Chanjoo , Esmaeli Bita , Sa Ho-Seok 
Published: March 2018

BackgroundThis study investigated surgical outcomes of full-thickness eyelid everting sutures for lower lid epiblepharon and influential factors leading to surgical failure.MethodsA retrospective review was conducted of patients with lower lid epiblepharon who underwent surgical correction using the full-thickness eyelid everting suture technique. Lower lid epiblepharon was assessed preoperatively using a morphological classification (class I–IV) according to the horizontal skin fold height and a functional classification (grade 0–3) according to the severity of keratopathy. Four stitches with 5-0 coated polyglactin 910 sutures per eyelid were made, and all procedures were conducted under local anaesthesia in an office-based setting. To assess surgical outcomes, we evaluated undercorrection at 1 month and surgical failure at 6 months after the procedure. Several factors affecting surgical failure were also investigatedResultsSixty-eight eyes of 41 patients were included. There were no eyes showing an undercorrection at 1 month. Keratopathy was significantly improved at 6 months postoperation (P<0.01). All patients showed good cosmesis without undesired creation of a lower lid crease and no significant complications. Sixty-one eyes (89.7%) showed surgical success. Three patients (7.3%) required additional incisional surgery due to recurring irritation. The rate of surgical failure was significantly different between the patient groups classified by preoperative severity of keratopathy (P=0.026) and lower lid horizontal skin fold height (P<0.001). Multiple logistic regression analysis revealed that the lower lid horizontal skin fold height was significantly correlated with surgical failure (OR 18.367, P=0.002).ConclusionNon-incisional eyelid everting sutures have utility for the correction of lower lid epiblepharon with advantages including its simplicity, being performed in office under local anaesthesia and minimal changes in appearance. We suggest mild to moderate epiblepharon with class I or II horizontal skin fold height and grade 1 or 2 keratopathy as the criteria for considering this suture procedure.
Differences in the occurrence and characteristics of injuries between full-time and part-time dancers
Authors: Vassallo Amy Jo , Pappas Evangelos , Stamatakis Emmanuel , Hiller Claire E 
Published: March 2018

BackgroundProfessional dancers are at significant risk of injury due to the physical demands of their career. Despite their high numbers, the experience of injury in freelance or part-time dancers is not well understood. Therefore, the aim of this study was to examine the occurrence and characteristics of injury in part-time compared with full-time Australian professional dancers.MethodsData were collected using a cross-sectional survey distributed to employees of small and large dance companies and freelance dancers in Australia. Statistical comparisons between full-time and part-time dancer demographics, dance training, injury prevalence and characteristics were made using χ2, two-tailed Fisher’s exact tests, independent t-tests and Mann-Whitney U tests.ResultsA total of 89 full-time and 57 part-time dancers were included for analysis. A higher proportion of full-time dancers (79.8%) than part-time dancers (63.2%) experienced an injury that impacted on their ability to dance in the past 12 months (p=0.035). Injuries characteristics were similar between groups with fatigue being the most cited contributing factor. Part-time dancers took longer to seek treatment while a higher proportion of full-time dancers were unable to dance in any capacity following their injury.ConclusionMore full-time dancers sustained an injury in the past 12 months, and were unable to dance in any capacity following their injury. However injuries still commonly occurred in part-time dancers without necessarily a large volume of dance activity. Part-time dancers often access general community clinicians for treatment, who may need additional education to practically advise on appropriate return to dance.
Monosomy 18p is a risk factor for facioscapulohumeral dystrophy
Authors: Balog Judit , Goossens Remko , Lemmers Richard J L F , Straasheijm Kirsten R , van der Vliet Patrick J , Heuvel Anita van den , Cambieri Chiara , Capet Nicolas , Feasson Léonard , Manel Veronique , Contet Julian , Kriek Marjolein , Donlin-Smith Colleen M , Ruivenkamp Claudia A L , Heard Patricia , Tapscott Stephen J , Cody Jannine D , Tawil Rabi , Sacconi Sabrina , van der Maarel Silvère M 
Published: March 2018

Background18p deletion syndrome is a rare disorder caused by partial or full monosomy of the short arm of chromosome 18. Clinical symptoms caused by 18p hemizygosity include cognitive impairment, mild facial dysmorphism, strabismus and ptosis. Among other genes, structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) is hemizygous in most patients with 18p deletions. Digenic inheritance of a SMCHD1 mutation and a moderately sized D4Z4 repeat on a facioscapulohumeral muscular dystrophy (FSHD) permissive genetic background of chromosome 4 can cause FSHD type 2 (FSHD2).ObjectivesSince 12% of Caucasian individuals harbour moderately sized D4Z4 repeats on an FSHD permissive background, we tested if people with 18p deletions are at risk of developing FSHD.MethodsTo test our hypothesis we studied different cellular systems originating from individuals with 18p deletions not presenting FSHD2 phenotype for transcriptional and epigenetic characteristics of FSHD at D4Z4. Furthermore, individuals with an idiopathic muscle phenotype and an 18p deletion were subjected to neurological examination.ResultsPrimary fibroblasts hemizygous for SMCHD1 have a D4Z4 chromatin structure comparable with FSHD2 concomitant with DUX4 expression after transdifferentiation into myocytes. Neurological examination of 18p deletion individuals from two independent families with a moderately sized D4Z4 repeat identified muscle features compatible with FSHD.Conclusions18p deletions leading to haploinsufficiency of SMCHD1, together with a moderately sized FSHD permissive D4Z4 allele, can associate with symptoms and molecular features of FSHD. We propose that patients with 18p deletion should be characterised for their D4Z4 repeat size and haplotype and monitored for clinical features of FSHD.
Venous waveform morphological changes associated with treatment of symptomatic venous sinus stenosis
Authors: West James L , Garner Rebecca M , Greeneway Garret P , Traunero Justin R , Aschenbrenner Carol A , Singh Jasmeet , Wolfe Stacey Q , Fargen Kyle M 
Published: March 2018

IntroductionVenous outflow obstruction is recognized as a contributing factor in a subset of patients with idiopathic intracranial hypertension (IIH). Little is known about venous sinus waveform morphology or how it changes after stenting.MethodsFifteen patients with IIH underwent waveform recording during catheter venography and manometry. Ten patients (Group A) with venous sinus stenosis and pressure gradient ≥7 mm Hg underwent waveform recording during awake venography and during stenting under general anesthesia. Five control IIH patients (Group B) without a gradient underwent awake recording only.ResultsGroup A patients underwent successful stenting with reduction of their gradient from 15.1±6.19 mm Hg to 1.2±0.60 mm Hg. This resulted in an amplitude reduction from 8.3 mm Hg to 2.8 mm Hg (P=0.02). Qualitative evaluation of the waveform yielded a number of novel findings. In Group A before stenting, the observed waveform progressed from an intracranial pressure (ICP)-dominated to central venous pressure (CVP)-dominated waveform. Stenting abolished the high amplitude waveform and smoothed the transition from the intracranial to central venous measurement points. Group B displayed primarily CVP-influenced waveforms distal and proximal to the transverse-sigmoid junction along with respiratory variability of the waveform, absent in 8/10 Group A patients. General anesthesia appeared to blunt the waveform in 5/10 Group A patients.ConclusionThe cerebral venous waveform appears to be influenced by both the ICP and CVP waveforms. As measurement moves proximally, the waveform progressively changes to mirror the CVP waveform. Venous sinus stenosis results in a high amplitude waveform which improves with treatment of the stenosis.
Establishment and application of an index system for prevention of coal workers’ pneumoconiosis: a Delphi and analytic hierarchy process study in four state-owned coal enterprises of China
Authors: Cui Kai , Shen Fuhai , Han Bing , Liu Hongbo , Chen Jie 
Published: March 2018

ObjectiveTo explore the difference of cumulative incidence rate of coal workers’ pneumoconiosis (CWP) among four large state-owned coal enterprises in northern China, we created an index system for evaluating the quality of comprehensive measures against CWP and applied the system to evaluate and compare the measures of the four coal enterprises.MethodsA two-round Delphi investigation was conducted to identify the indicators in the index system. The weight values of the indicators were calculated with analytic hierarchy process methods. Measures of CWP, mine annals, records and other information in each coal mine of the four enterprises were collected. The evaluation scores, which ranged from 0 to 100, were calculated and compared with.ResultsA three-grade index system with 3 first-grade indicators, 9 second-grade indicators and 44 tertiary-grade indicators was established. The expert authority coefficient (Cr) was 0.75 and the Kendall’s coefficient of concordance (Kendall’s W) was 0.15 (χ2=193.30, P<0.001). The weight value of ‘Geological conditions’ was 0.43, equal to ‘Dust control engineering technology’, and that of ‘Occupational health management’ was 0.14. The medians and quartiles of the evaluation scores of comprehensive measures against CWP of the four enterprises were 58.38 (54.60~63.02), 64.63 (60.83~67.06), 72.99 (68.92~77.67) and 75.07 (70.73~79.20), respectively.ConclusionsThe index system could be effectively used for evaluation and comparison of the comprehensive measures against CWP among different enterprises. The geological conditions and dust control engineering technology played an important role in preventing and controlling CWP.
Utility and Generalizability of Multistate, Population-Based Cancer Registry Data for Rural Cancer Surveillance Research in the United States
Authors: Zahnd Whitney E. , Jenkins Wiley D. , James Aimee S. , Izadi Sonya R. , Steward David E. , Fogleman Amanda J. , Colditz Graham A. , Brard Laurent 
Published: March 2018

Abstract
More than 46 million Americans live in rural areas, but rural populations remain relatively understudied in cancer disparities research. However, several analyses of multistate cancer registry data that describe the rural cancer incidence burden have been recently published. In light of this, our article aims to characterize the utility and generalizability of multistate, population-based cancer registry datasets for rural cancer surveillance research. First, we describe the accessibility, geographic coverage, available variables, and strengths and weaknesses of five data sources. Second, we evaluate two of these data sources—the North American Association of Central Cancer Registries (NAACCR) public use dataset (93% population coverage) and the Surveillance Epidemiology and End Results (SEER) 18 dataset (28% population coverage)—on their characterization of rural–urban cancer incidence rates and sociodemographic representation. The five data sources varied in geographic coverage and extent of available variables. SEER 18′s cancer rates sociodemographic representation differed from the more geographically representative NAACCR data. We suggest that SEER increase its geographic coverage to improve their generalizability and to take advantage of their utility to assess disparities along the cancer control continuum. We also suggest that non-SEER data sources be utilized more frequently to capitalize on their extensive geographic coverage. Cancer Epidemiol Biomarkers Prev; 27(11); 1252–60. ©2018 AACR.
The Pattern of Mesenchymal Stem Cell Expression Is an Independent Marker of Outcome in Multiple Myeloma
Authors: Schinke Carolina , Qu Pingping , Mehdi Syed J. , Hoering Antje , Epstein Joshua , Johnson Sarah K. , van Rhee Frits , Zangari Maurizio , Thanendrarajan Sharmilan , Barlogie Bart , Davies Faith E. , Yaccoby Shmuel , Morgan Gareth J. 
Published: March 2018

Abstract
Purpose: Mesenchymal stem cells (MSC) are an essential component of the bone marrow microenvironment and have shown to support cancer evolution in multiple myeloma. Despite the increasing evidence that multiple myeloma MSCs differ from their healthy counterparts, little knowledge exists as to whether MSCs independently influence disease outcome. The aim of this study was to determine the importance of MSCs in disease progression and outcome in multiple myeloma.
Experimental Design: To determine the impact of MSCs on multiple myeloma outcome in an in vivo system, we first identified genes from cultured MSCs that were specific to MSC expression and were not or minimally expressed in plasma cells (PC) or other cells present in bone marrow aspirates. We then applied this MSC gene signature to whole bone marrow biopsies of multiple myeloma patients compared with healthy controls and determined MSC expression scores specific to multiple myeloma and predictive of outcome.
Results: We show that multiple myeloma MSC gene expression signatures can differentiate multiple myeloma from monoclonal gammopathy and smoldering multiple myeloma (SMM) as well as from healthy controls and treated multiple myeloma patients who have achieved a complete remission. We identified a prognostic gene score based on three MSC specific genes, COL4A1, NPR3 and ITGBL1, that was able to predict progression-free survival in multiple myeloma patients and progression into multiple myeloma from SMM.
Conclusions: Our findings show that progression of multiple myeloma and of SMM into multiple myeloma does not rely solely on intrinsic PC factors, but is independently affected by the biology of the surrounding microenvironment. Clin Cancer Res; 24(12); 2913–9. ©2018 AACR.
Chimeric Antigen Receptor T Cell–Mediated Neurotoxicity in Nonhuman Primates
Authors: Taraseviciute Agne , Tkachev Victor , Ponce Rafael , Turtle Cameron J. , Snyder Jessica M. , Liggitt H. Denny , Myerson David , Gonzalez-Cuyar Luis , Baldessari Audrey , English Chris , Yu Alison , Zheng Hengqi , Furlan Scott N. , Hunt Daniel J. , Hoglund Virginia , Finney Olivia , Brakke Hannah , Blazar Bruce R. , Berger Carolina , Riddell Stanley R. , Gardner Rebecca , Kean Leslie S. , Jensen Michael C. 
Published: March 2018

AbstractChimeric antigen receptor (CAR) T-cell immunotherapy has revolutionized the treatment of refractory leukemias and lymphomas, but is associated with significant toxicities, namely cytokine release syndrome (CRS) and neurotoxicity. A major barrier to developing therapeutics to prevent CAR T cell–mediated neurotoxicity is the lack of clinically relevant models. Accordingly, we developed a rhesus macaque (RM) model of neurotoxicity via adoptive transfer of autologous CD20-specific CAR T cells. Following cyclophosphamide lymphodepletion, CD20 CAR T cells expand to 272 to 4,450 cells/μL after 7 to 8 days and elicit CRS and neurotoxicity. Toxicities are associated with elevated serum IL6, IL8, IL1RA, MIG, and I-TAC levels, and disproportionately high cerebrospinal fluid (CSF) IL6, IL2, GM-CSF, and VEGF levels. During neurotoxicity, both CD20 CAR and non-CAR T cells accumulate in the CSF and in the brain parenchyma. This RM model demonstrates that CAR T cell–mediated neurotoxicity is associated with proinflammatory CSF cytokines and a pan–T cell encephalitis.Significance: We provide the first immunologically relevant, nonhuman primate model of B cell–directed CAR T-cell therapy–mediated CRS and neurotoxicity. We demonstrate CAR and non-CAR T-cell infiltration in the CSF and in the brain during neurotoxicity resulting in pan-encephalitis, accompanied by increased levels of proinflammatory cytokines in the CSF. Cancer Discov; 8(6); 750–63. ©2018 AACR.This article is highlighted in the In This Issue feature, p. 663
GHOST: A Satellite Mission Concept for Persistent Monitoring of Stratospheric Gravity Waves Induced by Severe Storms
Authors: Tratt David M. , Hackwell John A. , Valant-Spaight Bonnie L. , Walterscheid Richard L. , Gelinas Lynette J. , Hecht James H. , Swenson Charles M. , Lampen Caleb P. , Alexander M. Joan , Hoffmann Lars , Nolan David S. , Miller Steven D. , Hall Jeffrey L. , Atlas Robert , Marks Frank D. , Partain Philip T. 
Published: March 2018

AbstractThe prediction of tropical cyclone rapid intensification is one of the most pressing unsolved problems in hurricane forecasting. The signatures of gravity waves launched by strong convective updrafts are often clearly seen in airglow and carbon dioxide thermal emission spectra under favorable atmospheric conditions. By continuously monitoring the Atlantic hurricane belt from the main development region to the vulnerable sections of the continental United States at high cadence, it will be possible to investigate the utility of storm-induced gravity wave observations for the diagnosis of impending storm intensification. Such a capability would also enable significant improvements in our ability to characterize the 3D transient behavior of upper-atmospheric gravity waves and point the way to future observing strategies that could mitigate the risk to human life caused by severe storms. This paper describes a new mission concept involving a midinfrared imager hosted aboard a geostationary satellite positioned at approximately 80°W longitude. The sensor’s 3-km pixel size ensures that the gravity wave horizontal structure is adequately resolved, while a 30-s refresh rate enables improved definition of the dynamic intensification process. In this way the transient development of gravity wave perturbations caused by both convective and cyclonic storms may be discerned in near–real time.