bluuebunny/crossref_metadata_2025_split huggingface dataset:
JDP2 overexpression provokes cardiac dysfunction in mice
Authors: Heger Jacqueline , Bornbaum Julia , Würfel Alona , Hill Christian , Brockmann Nils , Gáspár Renáta , Pálóczi János , Varga Zoltán V. , Sárközy Márta , Bencsik Péter , Csont Tamás , Török Szilvia , Kojonazarov Baktybek , Schermuly Ralph Theo , Böngler Kerstin , Parahuleva Mariana , Ferdinandy Peter , Schulz Rainer , Euler Gerhild 
Published: May 2018

AbstractThe transcriptional regulator JDP2 (Jun dimerization protein 2) has been identified as a prognostic marker for patients to develop heart failure after myocardial infarction. We now performed in vivo studies on JDP2-overexpressing mice, to clarify the impact of JDP2 on heart failure progression. Therefore, during birth up to the age of 4 weeks cardiac-specific JDP2 overexpression was prevented by doxycycline feeding in transgenic mice. Then, JDP2 overexpression was started. Already after 1 week, cardiac function, determined by echocardiography, decreased which was also resembled on the cardiomyocyte level. After 5 weeks blood pressure declined, ejection fraction and cardiac output was reduced and left ventricular dilatation developed. Heart weight/body weight, and mRNA expression of ANP, inflammatory marker genes, collagen and fibronectin increased. Collagen 1 protein expression increased, and fibrosis developed. As an additional sign of elevated extracellular matrix remodeling, matrix metalloproteinase 2 activity increased in JDP2 mice. Thus, JDP2 overexpression is deleterious to heart function in vivo. It can be concluded that JDP2 overexpression provokes cardiac dysfunction in adult mice that is accompanied by hypertrophy and fibrosis. Thus, induction of JDP2 is a maladaptive response contributing to heart failure development.
Quantum Cascade Laser-Based Infrared Microscopy for Label-Free and Automated Cancer Classification in Tissue Sections
Authors: Kuepper Claus , Kallenbach-Thieltges Angela , Juette Hendrik , Tannapfel Andrea , Großerueschkamp Frederik , Gerwert Klaus 
Published: May 2018

AbstractA feasibility study using a quantum cascade laser-based infrared microscope for the rapid and label-free classification of colorectal cancer tissues is presented. Infrared imaging is a reliable, robust, automated, and operator-independent tissue classification method that has been used for differential classification of tissue thin sections identifying tumorous regions. However, long acquisition time by the so far used FT-IR-based microscopes hampered the clinical translation of this technique. Here, the used quantum cascade laser-based microscope provides now infrared images for precise tissue classification within few minutes. We analyzed 110 patients with UICC-Stage II and III colorectal cancer, showing 96% sensitivity and 100% specificity of this label-free method as compared to histopathology, the gold standard in routine clinical diagnostics. The main hurdle for the clinical translation of IR-Imaging is overcome now by the short acquisition time for high quality diagnostic images, which is in the same time range as frozen sections by pathologists.
Vector polymorphic beam
Authors: Rodrigo José A. , Alieva Tatiana 
Published: May 2018

AbstractA scalar polymorphic beam is designed with independent control of its intensity and phase along a strongly focused laser curve of arbitrary shape. This kind of beam has been found crucial in the creation of freestyle laser traps able to confine and drive the motion of micro/nano-particles along reconfigurable 3D trajectories in real time. Here, we present and experimentally prove the concept of vector polymorphic beam adding the benefit of independent design of the light polarization along arbitrary curves. In particular, we consider polarization shaped tangential and orthogonal to the curve that are of high interest in optical manipulation and laser micromachining. The vector polymorphic beam is described by a surprisingly simple closed-form expression and can be easily generated by using a computer generated hologram.
Multiphysics modelling approach to microwave heating of cerium oxide particles in diverse packing situations
Authors: Hammoud Hussein , Valdivieso François , Vaucher Sébastien 
Published: May 2018

In this work, a single‐mode resonant microwave cavity (2.45 GHz) is loaded with spherical particles. A weakly coupled electromagnetic (EM)–thermal solver is used iteratively to determine how the microscopic geometry (local curvatures between the particles, grain size and neck size) modifies the EM field, and in turn the thermal field in the particles and also to quantify the microwave effect for an experimental process. The modelling is performed with the conformal finite element solver COMSOL Multiphysics. Moreover, this study will show that the electric field norm increases for one spherical particle of ceria with different sizes and consequently the temperature increases. In addition, the electric field and heating behaviour have been studied in the case of three particles with different neck sizes. Finally, the effect of the configuration versus the E‐field direction has been studied for three particles and has a significant result.
The XXL Survey
Authors: Guglielmo V. , Poggianti B. M. , Vulcani B. , Moretti A. , Fritz J. , Gastaldello F. , Adami C. , Caretta C. A. , Willis J. , Koulouridis E. , Ramos Ceja M. E. , Giles P. , Baldry I. , Birkinshaw M. , Bongiorno A. , Brown M. , Chiappetti L. , Driver S. , Elyiv A. , Evrard A. , Grootes M. , Guennou L. , Hopkins A. , Horellou C. , Iovino A. , Maurogordato S. , Owers M. , Pacaud F. , Paltani S. , Pierre M. , Plionis M. , Ponman T. , Robotham A. , Sadibekova T. , Smolčić V. , Tuffs R. , Vignali C. 
Published: May 2018

Context. Superclusters form from the largest enhancements in the primordial density perturbation field and extend for tens of Mpc, tracing the large-scale structure of the Universe. X-ray detections and systematic characterisations of superclusters and the properties of their galaxies have only been possible in the last few years.
Aims. We characterise XLSSsC N01, a rich supercluster at z ~ 0.3 detected in the XXL Survey, composed of X-ray clusters of different virial masses and X-ray luminosities. As one of the first studies on this topic, we investigate the stellar populations of galaxies in different environments in the supercluster region.
Methods. We study a magnitude-limited (r ≤ 20) and a mass-limited sample (log(M*∕M⊙) ≥ 10.8) of galaxies in the virialised region and in the outskirts of 11 XLSSsC N01 clusters, in high-density field regions, and in the low-density field. We compute the stellar population properties of galaxies using spectral energy distribution (SED) and spectral fitting techniques, and study the dependence of star formation rates (SFR), colours, and stellar ages on environment.
Results. For r ≤ 20, the fraction of star-forming/blue galaxies, computed either from the specific-SFR (sSFR) or rest-frame colour, shows depletion within the cluster virial radii, where the number of galaxies with log (sSFR/ yr−1) > −12 and with (g − r)restframe < 0.6 is lower than in the field. For log(M*∕M⊙) ≥ 10.8, no trends with environment emerge, as massive galaxies are mostly already passive in all environments. No differences among low- and high-density field members and cluster members emerge in the sSFR-mass relation in the mass-complete regime. Finally, the luminosity-weighted age–mass relation of the passive populations within cluster virial radii show signatures of recent environmental quenching.
Conclusions. The study of luminous and massive galaxies in this supercluster shows that while environment has a prominent role in determining the fractions of star-forming/blue galaxies, its effects on the star formation activity in star-forming galaxies are negligible.
Deep secrets of intermediate-mass giants and supergiants
Authors: Smiljanic R. , Donati P. , Bragaglia A. , Lemasle B. , Romano D. 
Published: May 2018

Context. Recent observational results have demonstrated an increase in the surface Na abundance that correlates with stellar mass for red giants between 2 and 3M⊙. This trend supports evolutionary mixing processes as the explanation for Na overabundances seen in some red giants. In this same mass range, the surface Al abundance was shown to be constant.Aims. Our main aim was to extend the investigation of the Na and Al surface abundances to giants more massive than 3M⊙. We sought to establish accurately whether the Na abundances keep increasing with stellar mass or a plateau is reached. In addition, we investigated whether mixing can affect the surface abundance of Al in giants more massive than 3M⊙.Methods. We obtained new high-resolution spectra of 20 giants in the field of 10 open clusters; 17 of these stars were found to be members of 9 clusters. The giants have masses between 2.5M⊙and 5.6M⊙. A model atmosphere analysis was performed and abundances of up to 22 elements were derived using equivalent widths. Additionally, abundances of C, N, and O were determined using spectrum synthesis. The abundances of Na and Al were corrected for non-local thermodynamic equilibrium (non-LTE) effects. Moreover, to extend the mass range of our sample, we collected from the literature high-quality C, N, O, and Na abundances of 32 Galactic Cepheids with accurate masses in the range between 3M⊙and 14M⊙.Results. The surface abundances of C, N, O, Na, and Al were compared to predictions of stellar evolution models with and without the inclusion of rotation-induced mixing. The surface abundances of most giants and Cepheids of the sample can be explained by models without rotation. For giants above Ȉ2.5M⊙, the Na abundances reach a plateau level of about [Na/Fe] ~ 0.20–0.25 dex (in non-LTE). This is true for both Cepheids and giants in open clusters. Regarding Al, the non-LTE [Al/Fe] ratios are mostly close to solar and suggest that Al is not affected by the first dredge-up up to ~5.0M⊙. Our results support previous works that found models with rotation to overestimate the mixing effects in intermediate-mass stars.
The central velocity dispersion of the Milky Way bulge
Authors: Valenti E. , Zoccali M. , Mucciarelli A. , Gonzalez O. A. , Surot F. , Minniti D. , Rejkuba M. , Pasquini L. , Fiorentino G. , Bono G. , Rich R. M. , Soto M. 
Published: May 2018

Context. Current spectroscopic and photometric surveys are providing a comprehensive view of the Milky Way bulge stellar population properties with unprecedented accuracy. This in turn allows us to explore the correlation between kinematics and stellar density distribution, crucial to constrain the models of Galactic bulge formation.
Aims. The Giraffe Inner Bulge Survey (GIBS) revealed the presence of a velocity dispersion peak in the central few degrees of the Galaxy by consistently measuring high velocity dispersion in the three central most fields. Due to the suboptimal distribution of these fields, all being at negative latitudes and close to each other, the shape and extension of the sigma peak is poorly constrained. In this study we address this by adding new observations distributed more uniformly and in particular including fields at positive latitudes that were missing in GIBS.
Methods. Observations with Multi Unit Spectroscopic Explorer (MUSE) were collected in four fields at (l, b) = (0°, +2°), (0°, −2°), (+1°, −1°), and (−1°, +2°). Individual stellar spectra were extracted for a number of stars comprised between ~500 and ~1200, depending on the seeing and the exposure time. Velocity measurements are done by cross-correlating observed stellar spectra in the CaT region with a synthetic template, and velocity errors are obtained through Monte Carlo simulations, cross-correlating synthetic spectra with a range of different metallicities and different noise characteristics.
Results. We measure the central velocity dispersion peak within a projected distance from the Galactic center of ~280 pc, reaching σVGC ~ 140 km s−1 at b = −1°. This is in agreement with the results obtained previously by GIBS at negative longitude. The central sigma peak is symmetric with respect to the Galactic plane, with a longitude extension at least as narrow as predicted by GIBS. As a result of the Monte Carlo simulations we present analytical equations for the radial velocity measurement error as a function of metallicity and signal-to-noise ratio for giant and dwarf stars.
Comparison of Constructive Interference in Steady-State and T1-Weighted MRI Sequence at Detecting Pituitary Adenomas in Cushing's Disease Patients
Authors: Lang Min , Habboub Ghaith , Moon Doksu , Bandyopadhyay Abin , Silva Danilo , Kennedy Laurence , Kshettry Varun , Recinos Pablo 
Published: May 2018

Background T1-weighted magnetic resonance imaging (MRI) remains the standard pituitary imaging sequence. However, up to 50% of pituitary adenomas are missed with standard imaging in Cushing's disease (CD) patients. Utility of other imaging sequences needs be explored.
Objective To compare a T2-gradient echo sequence, constructive interference in steady state (CISS), with a contrast-enhanced (CE) T1-weighted sequence, volume-interpolated breath-hold examination (VIBE), in the detection of pituitary adenomas in CD patients.
Design Retrospective analysis of CD patients who underwent endoscopic transsphenoidal pituitary adenomectomy at our institution.
Patients and Measurement Twelve patients were included in the study. Two neuroradiologists, who were blinded to the patients' clinical and surgical findings, independently reviewed the CE-VIBE and CISS images. Localization of pituitary adenoma from imaging was compared with intraoperative localization.
Results The averaged sensitivity of detecting pituitary adenoma in CD patients was not significantly different between CE-VIBE sequence (63%) and CISS sequence (54%). The positive predictive value was 75% (Observer A) and 100% (Observer B) with CE-VIBE sequence, and 64% (Observer A) and 100% (Observer B) with CISS sequence. In two patients, pituitary adenoma was easily localized with CISS sequence but hard to detect with CE-VIBE sequence. In two other patients, the adenoma was much better delineated on CE-VIBE sequence.
Conclusion In our series, the addition of CISS sequence to T1-weighted MRI imaging protocols improved the detection of pituitary adenomas in CD patients. CISS sequence may be a useful adjunct to T1-weighted pituitary MRI protocols and an appropriate alternative for patients with gadolinium contraindications.
Risk Factors for Umbilical Cord Prolapse at the Time of Artificial Rupture of Membranes
Authors: Kawakita Tetsuya , Huang Chun-Chih , Landy Helain 
Published: May 2018

Objective The aim of the study was to examine the association between cervical exam at the time of artificial rupture of membranes (AROM) and cord prolapse.
Study Design We conducted a retrospective cohort study using the data from the Consortium on Safe Labor. We included women with cephalic presentation and singleton pregnancies at ≥ 23 weeks' gestation who underwent AROM during the course of labor. Multivariable logistic regression was used to calculate the adjusted odds ratio (aOR) with 95% confidence interval (95% CI), controlling for prespecified covariates.
Results Of 57,204 women who underwent AROM, cord prolapse occurred in 113 (0.2%). Compared with dilation 6 to 10 cm + station ≥ 0 at the time of AROM, <6 cm + any station and 6–10 cm + station ≤ −3 were associated with increased risks of cord prolapse (<6 cm + station ≤ −3 [aOR, 2.29; 95% CI, 1.02–5.40]; <6 cm + station −2.5 to −0.5 [aOR, 2.34; 95% CI, 1.23–4.97]; <6 cm + station ≥ 0 [aOR, 3.31; 95% CI, 1.39–8.09]; and 6–10 cm + station ≤ −3 [aOR, 5.47; 95% CI, 1.35–17.48]).
Conclusion Cervical dilation < 6 cm with any station and 6 to 10 cm with station ≤ −3 were associated with a higher risk of cord prolapse.
Medical-grade ultra-high molecular weight polyethylene: Past, current and future
Authors: Zaribaf Fedra Parnian 
Published: May 2018

Ultra-high molecular weight polyethylene is a semi-crystalline polymer (45–60%) with six decades of orthopaedic applications. This polymer has a high fracture toughness (30 kJ m−2) which comes from the molecular weight and the chain entanglements. Adverse alteration of the properties may lead to the part's pre-mature failure. This paper reviews the current manufacturing methods, and their effect on the properties of the polymer. The review also focused on the attempts of enhancing the polymer properties. The main cause of failure is implant loosing owing to the polymeric wear particles. Many manufacturers have attempted to enhance the wear and oxidation properties of the polymer, and the outcome of the new technologies is critically reviewed. Finally, the review explores the potential for future developments. This review was submitted as part of the 2018 Materials Literature Review Prize of the Institute of Materials, Minerals and Mining run by the Editorial Board of MST. Sponsorship of the prize by TWI Ltd is gratefully acknowledged.
Phytoplankton ecology in the Bay of Quinte, Lake Ontario: Spatial distribution, dynamics and heterogeneity
Authors: Munawar M. , Fitzpatrick M. , Niblock H. , Kling H. , Lorimer J. , Rozon R. 
Published: May 2018

The Bay of Quinte, a large riverine embayment located on the northeastern shores of Lake Ontario, has a long history of cultural eutrophication. While the Bay has been the subject of an extensive research and monitoring program that began in 1972, phytoplankton assessments have been limited to 2–3 index stations with few exceptions. Our study consisted of three separate surveys conducted during the summer of 2010 (June, August, September) at 12 sites spread evenly throughout the Bay. Among the major findings were that conditions in the Bay ranged from oligo- to mesotrophic in June, but were primarily eutrophic in August and September with algal blooms observed at 50–75% of the sites; the spatial extent limited only by incursions of oligotrophic water from Lake Ontario. Furthermore, primary productivity in the Bay (e.g. 43.3–109.6 mg C m−3 h−1 in September) was among the highest reported in the Great Lakes, indicative of a phytoplankton community very well adapted to its environment. We also found that the Bay of Quinte supported a diverse algal flora containing 140 unique species in June, 209 in August and 169 in September which we attribute to the variable physical environment. Of the 35 phytoplankton samples assessed, Diatomeae were the most prevalent taxa in 16 of those assemblages followed by Cyanophyta (including many toxigenic species) in 12. The relative importance of diatoms are often overlooked in studies of eutrophication yet two species in particular, Aulacoseira granulata and A. ambigua, were major contributors to both the algal standing crop and the elevated rates of primary production. We recommend that future research be directed at understanding the ecology, physiology and dynamics of these filamentous diatoms as well as their associations with filamentous and colonial cyanobacteria.
Pregnancy Management
Authors: Mathiesen Amber , Roy Kali 
Published: May 2018

Abstract
This chapter describes a patient’s pregnancy options and subsequent care after a pregnancy becomes “high risk” due to a known genetic condition or birth defect. It reviews the reproductive options available, including continuation of pregnancy, adoption, and pregnancy termination. The timing of pregnancy termination is described, including methods used during the first and second trimesters, as well as later term. This chapter also reviews the possible management referrals that may be made if the patient chooses to continue the pregnancy, including perinatology, specialized imaging, cardiology, neonatology, fetal surgery and interventions, pediatric surgery, pediatric subspecialties, pathology, and palliative care. It also discusses referrals for further support.
Residual enhancing disease after surgery for glioblastoma: evaluation of practice in the United Kingdom
Authors: Ma Ruichong , Chari Aswin , Brennan Paul M , Alalade Andrew , Anderson Ian , Solth Anna , Marcus Hani J , Watts Colin ,   British Neurosurgical Trainee Research Collaborative, Kolias Angelos , Sinha Rohit , O’Neill Kevin , Paine Heidi , Rasul Fahid , Ashkan Keyoumars , Corns Robert , Jenkinson Michael , Kitchen Neil , Holliman Damian , Glancz Laurence , Aly Ahmed , Smith Stuart , Plaha Puneet , Dyson Edward , Toescu Sebastian , Haliasos Nick , Ghosh Arnab , McKintosh Edward , Rominiyi Olamide , Jellinek David , Gallagher Mat , Jones Tim , Wykes Victoria , Grundy Paul , Haq Imran , Brydon Howard 
Published: May 2018

Abstract

Background
A growing body of clinical data highlights the prognostic importance of achieving gross total resection (GTR) in patients with glioblastoma. The aim of this study was to determine nationwide practice and attitudes towards achieving GTR and dealing with residual enhancing disease.

Methods
The study was in 2 parts: an electronic questionnaire sent to United Kingdom neuro-oncology surgeons to assess surgical practice followed by a 3-month prospective, multicenter observational study of current neurosurgical oncology practice.

Results
Twenty-seven surgeons representing 22 neurosurgical units completed the questionnaire. Prospective data were collected for 113 patients from 15 neurosurgical units. GTR was deemed to be achieved at time of surgery in 82% (91/111) of cases, but in only 45% (36/80) on postoperative MRI. Residual enhancing disease was deemed operable in 16.3% (13/80) of cases, however, no patient underwent early repeat surgery for residual enhancing disease. The most commonly cited reason (38.5%, 5/13) was perceived lack of clinical benefit.

Conclusion
There is a subset of patients for whom GTR is thought possible, but not achieved at surgery. For these patients, early repeat resection may improve overall survival. Further prospective surgical research is required to better define the prognostic implications of GTR for residual enhancing disease and examine the potential benefit of this early re-intervention.
Relationships Among DNP and PhD Students After Implementing a Doctoral Student Organization
Authors: Travers Jasmine L. , Weis Marjorie , Merrill Jacqueline A. 
Published: May 2018

Abstract

BACKGROUND
Early career contact, between clinically focused DNP and research-focused PhD nursing students, may encourage desirable intradisciplinary synergies.

AIM
The aim of the study was to assess relationships among DNP and PhD nursing students after initiating a doctoral student organization.

METHOD
An online survey assessed student interaction pre- and post-doctoral student organization implementation. Analysis consisted of paired t-test, social network analysis, and content analysis methods.

RESULTS
Response rates were 72 percent (n = 86) and 60 percent (n = 72) before and after implementation. Network density and centralization increased by 17 percent and 3 percent, respectively; intradisciplinary ties increased by 39 percent. The average student had approximately two new relationships; clique membership increased by 60 percent. Narrative responses corroborated network measurements.

CONCLUSION
We documented additional integration and organized communication among students after this strategy to increase collaboration. Educators preparing nurses to work across research and practice may consider network analysis methods to evaluate their efforts.