bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electromagnetic wave absorption and compressive behavior of a three-dimensional metamaterial absorber based on 3D printed honeycomb
Authors: Jiang Wei , Yan Leilei , Ma Hua , Fan Ya , Wang Jiafu , Feng Mingde , Qu Shaobo 
Published: March 2018

AbstractLightweight structures with multi-functions such as electromagnetic wave absorption and excellent mechanical properties are required in spacecraft. A three-dimensional metamaterial absorber consisting of honeycomb and resistive films was proposed and fabricated through 3D printing and silk-screen printing technology. According to simulation and experiment results, the present three-dimensional metamaterial absorber can realize an absorptivity of more than 90% in a wide band of 3.53–24.00 GHz, and improve absorbing efficiency for transverse magnetic (TM) waves of oblique incidence angle from 0° to 70°. The compression test results reveal that compressive strength of the 3D printed honeycomb can reach 10.7 MPa with density of only 254.91 kg/m3, and the energy absorption per volume W
v
and per unit mass W
m
are 4.37 × 103 KJ/m3 and 17.14 KJ/Kg, respectively. The peak compressive strength and energy absorption per mass are at least 2.2 and 3 times comparing to metallic lattice cores with the same density. Outstanding electromagnetic wave absorption and mechanical performance make the present three-dimensional metamaterial absorber more competitive in engineering applications.
Human pluripotent stem cell derived HLC transcriptome data enables molecular dissection of hepatogenesis
Authors: Wruck Wasco , Adjaye James 
Published: March 2018

AbstractInduced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) differentiated into hepatocyte-like cells (HLCs) provide a defined and renewable source of cells for drug screening, toxicology and regenerative medicine. We previously reprogrammed human fetal foreskin fibroblast cells (HFF1) into iPSCs employing an episomal plasmid-based integration-free approach, this iPSC-line and the hESC lines H1 and H9 were used to model hepatogenesis in vitro. Biochemical characterisation confirmed glycogen storage, ICG uptake and release, urea and bile acid production, as well as CYP3A4 activity. Microarray-based transcriptome analyses was carried out using RNA isolated from the undifferentiated pluripotent stem cells and subsequent differentiation stages- definitive endoderm (DE) hepatic endoderm (HE) and HLCs. K-means identified 100 distinct clusters, for example, POU5F1/OCT4 marking the undifferentiated stage, SOX17 the DE stage, HNF4α the HE stage, and ALB specific to HLCs, fetal liver and primary human hepatocytes (PHH). This data descriptor describes these datasets which should be useful for gaining new insights into the molecular basis of hepatogenesis and associated gene regulatory networks.
Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
Authors: Ping Lingyan , Duong Duc M. , Yin Luming , Gearing Marla , Lah James J. , Levey Allan I. , Seyfried Nicholas T. 
Published: March 2018

AbstractPatients with Alzheimer’s disease (AD) and Parkinson’s disease (PD) often have overlap in clinical presentation and brain neuropathology suggesting that these two diseases share common underlying mechanisms. Currently, the molecular pathways linking AD and PD are incompletely understood. Utilizing Tandem Mass Tag (TMT) isobaric labeling and synchronous precursor selection-based MS3 (SPS-MS3) mass spectrometry, we performed an unbiased quantitative proteomic analysis of post-mortem human brain tissues (n=80) from four different groups defined as controls, AD, PD, and co-morbid AD/PD cases across two brain regions (frontal cortex and anterior cingulate gyrus). In total, we identified 11 840 protein groups representing 10 230 gene symbols, which map to ~65% of the protein coding genes in brain. The utility of including two reference standards in each TMT 10-plex assay to assess intra- and inter-batch variance is also described. Ultimately, this comprehensive human brain proteomic dataset serves as a valuable resource for various research endeavors including, but not limited to, the identification of disease-specific protein signatures and molecular pathways that are common in AD and PD.
Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides
Authors: Mathieu Cyrille , Augusto Marcelo T. , Niewiesk Stefan , Horvat Branka , Palermo Laura M. , Sanna Giuseppina , Madeddu Silvia , Huey Devra , Castanho Miguel A. R. B. , Porotto Matteo , Santos Nuno C. , Moscona Anne 
Published: March 2018

AbstractHuman paramyxoviruses include global causes of lower respiratory disease like the parainfluenza viruses, as well as agents of lethal encephalitis like Nipah virus. Infection is initiated by viral glycoprotein-mediated fusion between viral and host cell membranes. Paramyxovirus viral fusion proteins (F) insert into the target cell membrane, and form a transient intermediate that pulls the viral and cell membranes together as two heptad-repeat regions refold to form a six-helix bundle structure that can be specifically targeted by fusion-inhibitory peptides. Antiviral potency can be improved by sequence modification and lipid conjugation, and by adding linkers between the protein and lipid components. We exploit the uniquely broad spectrum antiviral activity of a parainfluenza F-derived peptide sequence that inhibits both parainfluenza and Nipah viruses, to investigate the influence of peptide orientation and intervening linker length on the peptides’ interaction with transitional states of F, solubility, membrane insertion kinetics, and protease sensitivity. We assessed the impact of these features on biodistribution and antiviral efficacy in vitro and in vivo. The engineering approach based on biophysical parameters resulted in a peptide that is a highly effective inhibitor of both paramyxoviruses and a set of criteria to be used for engineering broad spectrum antivirals for emerging paramyxoviruses.
A trifluoromethyl substituted wide bandgap conjugated polymer for non-fullerene polymer solar cells with 10.4% efficiency
Authors: Li Wanbin , Li Guangda , Guo Xia , Wang Yong , Guo Huan , Xu Qingqing , Zhang Maojie , Li Yongfang 
Published: March 2018

A new wide bandgap copolymer (PBZ-m-CF3) based on a trifluoromethyl-p-alkoxyphenyl substituted benzodithiophene unit is designed and synthesized. PSCs based on PBZ-m-CF3/ITIC with toluene as the solvent show a high PCE of 10.4% with a Voc of 0.94 V, a Jsc of 18.4 mA cm−2 and a FF of 60.2%.
Clinical Strategies for Sampling Word Recognition Performance
Authors: Schlauch Robert S. , Carney Edward 
Published: March 2018

Purpose
Computer simulation was used to estimate the statistical properties of searches for maximum word recognition ability (PB max). These involve presenting multiple lists and discarding all scores but that of the 1 list that produced the highest score. The simulations, which model limitations inherent in the precision of word recognition scores, were done to inform clinical protocols. A secondary consideration was a derivation of 95% confidence intervals for significant changes in score from phonemic scoring of a 50-word list.

Method
The PB max simulations were conducted on a “client” with flat performance intensity functions. The client's performance was assumed to be 60% initially and 40% for a second assessment. Thousands of estimates were obtained to examine the precision of (a) single lists and (b) multiple lists using a PB max procedure. This method permitted summarizing the precision for assessing a 20% drop in performance.

Results
A single 25-word list could identify only 58.4% of the cases in which performance fell from 60% to 40%. A single 125-word list identified 99.8% of the declines correctly. Presenting 3 or 5 lists to find PB max produced an undesirable finding: an increase in the word recognition score.

Conclusions
A 25-word list produces unacceptably low precision for making clinical decisions. This finding holds in both single and multiple 25-word lists, as in a search for PB max. A table is provided, giving estimates of 95% critical ranges for successive presentations of a 50-word list analyzed by the number of phonemes correctly identified.
1500 V three‐level forward converter with phase‐shifted control
Authors: Hong Feng , Li Longchun , Wu Yu , Ji Baojian , Zhou Yufei 
Published: March 2018

A 1500 V three‐level forward converter with phase‐shifted control is proposed to meet therequirements on medium‐ and high‐voltage DC bus of photovoltaic grid‐connectedsystem. The architecture of 1500 V DC bus is established by filtering thephase‐shifted outputs in series centrally, in which the internal filters of eachDC/DC converter are removed. The three‐level voltage is superimposed byphase‐shifting the rectified output voltages in series, which is beneficial todecrease the inductor current pulsation, diminish the ripple of output voltageand improve the system efficiency. The centralised filter contributes todownsizing the filter and reducing the system cost. With the introduction ofparallel‐series structure, the characteristics of low‐voltage stress areretained and the power transmission is improved. Meanwhile, the minimum value oftotal harmonic distortion (THD) with phase‐shifted control is obtained throughthe Fourier decomposition of three‐level voltage waveform. By analysing thevariation rule of THD with the change of conduction angle, the optimalsteady‐state operating point of the converter is achieved. The operatingprinciple of the proposed system is presented minutely in this study and aprototype has been established. The experimental results verify the validity ofthe proposed converter.
Improved mismatched filtering for ATV‐based passive bistatic radar
Authors: Gang Chen , Jun Wang , Shuai Guo , Jue Wang , Siyuan Su 
Published: March 2018

This study examines the problem of solving the Doppler ambiguity in analogue television (ATV)‐based passive bistatic radar. When mismatched filtering is used to deal with the range ambiguity at 19.2 km, the Doppler ambiguity caused by the 50 Hz field frequency is equally rising because of the signal‐to‐noise ratio (SNR) loss in the main lobe. Aiming at this problem, an improved mismatched filtering algorithm is proposed. In this new algorithm, the Doppler ambiguity sidelobe suppressing is considered into the cost function, and the mismatched filtering factor is acquired based on minimising the SNR loss, the range sidelobes energy and the Doppler sidelobes energy. Moreover, a batch version is applied to lower the computation. Then the performance of the improved mismatched filtering algorithm is verified by the theoretical analysis. Finally, the application of real data proved the effectiveness of the improved algorithm.
Efficient BeiDou DBZP‐based weak signal acquisition scheme for software‐defined receiver
Authors: Meng Qian , Liu Jian‐Ye , Zeng Qing‐Hua , Feng Shao‐Jun , Xu Rui 
Published: March 2018

Modulation with high‐rate Neumann–Hoffman (NH) code in BeiDou signals increases the complexity and calculation load in acquisition as the data bit transitions are more frequent and there is no pilot component for synchronisation which is used in other constellations. Among the current state of the art, double block zero padding (DBZP) method has great potential in reducing the calculation. However, traditional DBZP is very sensitive to bit transition and the misalignment of bit edge will cause serious power loss. To relieve the calculation load and acquire the weak signal successfully, an efficient BeiDou DBZP‐based scheme is proposed. The proposed scheme is optimised in two aspects: the NH code phase searching and correlation integration. The step size of the proposed NH code searching method is half an NH code bit which means the number of searches in one navigation message bit is only 40 and the computation load can be reduced greatly. Additionally, the proposed inherited correlation integration establishes a tight inherited structure between adjoining coherent integrations which can reduce the calculation burden further. The experiment results show that the proposed scheme can acquire as weak as 22 dBHz with only about 12% computation time of the traditional DBZP method.
New closed analytical solutions for geometrically thick fluid tori around black holes
Authors: Witzany V. , Jefremov P. 
Published: March 2018

Context. When a black hole is accreting well below the Eddington rate, a geometrically thick, radiatively inefficient state of the accretion disk is established. There is a limited number of closed-form physical solutions for geometrically thick (nonselfgravitating) toroidal equilibria of perfect fluids orbiting a spinning black hole, and these are predominantly used as initial conditions for simulations of accretion in the aforementioned mode. However, different initial configurations might lead to different results and thus observational predictions drawn from such simulations.
Aims. We aim to expand the known equilibria by a number of closed multiparametric solutions with various possibilities of rotation curves and geometric shapes. Then, we ask whether choosing these as initial conditions influences the onset of accretion and the asymptotic state of the disk.
Methods. We have investigated a set of examples from the derived solutions in detail; we analytically estimate the growth of the magneto-rotational instability (MRI) from their rotation curves and evolve the analytically obtained tori using the 2D magneto-hydrodynamical code HARM. Properties of the evolutions are then studied through the mass, energy, and angular-momentum accretion rates.
Results. The rotation curve has a decisive role in the numerical onset of accretion in accordance with our analytical MRI estimates: in the first few orbital periods, the average accretion rate is linearly proportional to the initial MRI rate in the toroids. The final state obtained from any initial condition within the studied class after an evolution of ten or more orbital periods is mostly qualitatively identical and the quantitative properties vary within a single order of magnitude. The average values of the energy of the accreted fluid have an irregular dependency on initial data, and in some cases fluid with energies many times its rest mass is systematically accreted.
Prise en charge chirurgicale par affaiblissement labio-mentonnier et corticotomies des déséquilibres dento-parodonto-musculaires de la région incisivo-canine mandibulaire
Authors: Chillès J.-G. , Riemenschneider-Chillès S. , Doustkam A.-A. , Chillès D. 
Published: March 2018

La région incisivo-canine mandibulaire est une clé de voûte mécanique sur laquelle s’exercent d’importantes forces centripètes musculaires et occlusales. En cas de faiblesse dentaire et/ou parodontale, et/ou de contraintes mécaniques exagérées, des situations de déséquilibres peuvent nuire à la stabilité de nos traitements orthodontiques et à la pérennité du parodonte.Nous proposons deux techniques chirurgicales pour prévenir et traiter ces situations :– l’affaiblissement labio-mentonnier chez l’enfant et l’adolescent en croissance;– les corticotomies avec allogreffe osseuse vestibulaire chez l’adulte.Ces deux techniques permettent une prise en charge fonctionnelle du déséquilibre mécanique, améliorent le biotype parodontal, et favorisent le repositionnement des incisives mandibulaires.
Sonographic Diagnosis of Meningoencephalitis in Newborns and Infants
Authors: Deeg Karl-Heinz 
Published: March 2018

AbstractPrenatal, neonatal meningoencephalitis and infections of the brain in older infants are often associated with serious complications which can be diagnosed by sonography through the open fontanelles. Most frequently postmeningitic hydrocephalus and subdural effusions occur. Rarer complications are brain abscesses and ventriculitis which are caused by gram negative bacteria such as E. coli, Serratia marcescens, Proteus and Enterobacter. A serious complication after ventriculitis is the development of compartment hydrocephalus. Multifocal small echogenic lesions scattered all over the brain are suspicious of fungal infections. Stripe-like echogenicities in the basal ganglia of newborns are typical for prenatal infections such as infections with cytomegalovirus, rubella, herpes, toxoplasma gondii and HIV. Late sequelae are intracranial cysts, multifocal encephalomalacia and intracranial calcifications. Color Doppler shows increased perfusion of the brain in the acute phase of the disease. Brain abscesses and infarcts are characterized by decreased or missing perfusion. Spectral Doppler shows increased flow velocities. Increased intracranial pressure causes an increase of the flow velocities in the intracranial part of the internal carotid artery in comparison with the extracranial part. All complications can be diagnosed by ultrasound. Other imaging methods such as MRI are only occasionally necessary.
Das Usher-Syndrom, eine Ziliopathie des Menschen
Authors: Wolfrum Uwe , Nagel-Wolfrum Kerstin 
Published: March 2018

ZusammenfassungDas humane Usher-Syndrom (USH) ist eine seltene, komplexe genetische Erkrankung, die sich in kombinierter Taubblindheit manifestiert. Aufgrund der Ausprägung des Krankheitsbilds werden 3 klinische Typen (USH1 – 3) unterschieden. Für eine korrekte Diagnose sind zusätzlich zu den auditorischen Tests im Zuge des Neugeborenenscreens auch frühe ophthalmologische Untersuchungen und eine molekulargenetische Abklärung notwendig. Die bislang 10 bekannten USH-Gene codieren für heterogene Proteine, die in Proteinnetzwerken miteinander in Funktionseinheiten kooperieren. Im Auge und im Ohr werden USH-Proteine vor allem in den mechanosensitiven Haarsinneszellen und den Stäbchen- und Zapfenphotorezeptorzellen exprimiert. In den Haarzellen sind die USH-Proteinnetzwerke sowohl für die korrekte Differenzierung der reizaufnehmenden Haarbündel als auch für den mechanisch-elektrischen Transduktionskomplex essenziell. In den Photorezeptorzellen sind USH-Proteine im Bereich des Ciliums lokalisiert, wo sie an intrazellulären Transportprozessen beteiligt sein dürften. Darüber hinaus ist ein USH-Proteinnetzwerk in den sog. „calyceal processes“, die das Außensegment der Photorezeptorzellen stabilisieren, zu finden. Das Fehlen der „calyceal processes“ und eines prominenten visuellen Phänotyps in der Maus disqualifiziert Mausmodelle als Modelle für die ophthalmologische Komponente von USH. Während Hörstörungen mit Hörgeräten und Cochleaimplantaten kompensiert werden können, gibt es für USH im Auge bislang keine praktikable Therapie. Derzeit werden genbasierte Therapiekonzepte, wie bspw. Genaddition, Applikationen von Antisense-Oligonukleotiden und TRIDs („translational readthrough inducing drugs“) zum Überlesen von Nonsense-Mutationen präklinisch evaluiert. Für USH1B/MYO7A läuft bereits die UshStat-Gentherapie als klinische Studie.
Inhibition of Tubulin β-chain May Play a Regulatory Role in the Development of Rheumatoid Arthritis
Authors: Zhao Yan , Li Shufeng , Jihong Pan , Zhang Rui , Li Zhiyuan , Meng Qingsong 
Published: March 2018

AbstractPathological characteristics of Rheumatoid arthritis (RA), a systemic autoimmune disease, includes abnormal proliferation of synovial fibroblasts and increased angiogenesis.The study assessed the effect of tubulin β-chain gene (TBB) gene knockdown on the behaviour of rheumatoid arthritis (RA) fibroblast-like synoviocytes (SFs), which is significantly affected by the synthesis of tubulin. Cultured SFs were isolated from the mixed knee-joint synovial tissue of five RA patients and treated with siRNA targeting TBB. Knockdown efficiency and expression of relevant genes were detected by RT-PCR following 24 h and 36 h of transfection. MTT, Transwell, and wound scratch assays and flow cytometric analysis were used to assess cell proliferation and invasive and migratory capacity following TBB knockdown. The expression of TBB was detected after inhibition of the ERK, STAT3 and NF-kB pathways. The expression of IL-17, TNF-α, IL-1α, IL1-β, and IL-6 was quantified following TBB knockdown. The proliferation, invasion, and migration of RASFs were significantly decreased following TBB knockdown. ELISA showed a significant decrease in interleukin 1β (IL-1β) secretion and insignificantly reduced secretion of TNF-α, IL-17, and IL-1α after TBB knockdown. The expression of TBB in RASFs decreased with the increasing concentration of a STAT3 pathway inhibitor while TBB expression increased after down regulation of the ERK pathway. These results support a protective role for TBB knockdown in suppressing RASFs, laying a foundation for further studies on the pathogenic mechanisms of RA.
Otomyiasis: Systematic Review
Authors: Rodríguez-Ruiz María , Acosta Ana , Cifuentes-Cardozo Eduardo , Chirveches María , Rosselli Diego 
Published: March 2018

Introduction Myiasis is a disease caused by fly larvae that grow in the tissues of animals and humans. It can cause a variety of local symptoms, like erythema or pain, depending on its location, and generalized symptomatology, such as fever and malaise. Myiasis can generate severe complications, for instance sepsis, or directly impact vital tissues. Its management varies depending on the location, and on the preferences of the doctor that faces this challenge. Myiasis usually occurs in tropical countries, and, in many places, it is not a rare condition. The cases are rarely reported, and there are no published management protocols.
Objective To review the literature regarding the most common agents, the predisposing factors and the treatment alternatives for otic myiasis, a rare form of human myiasis caused by the infestation of fly larvae in the ear cavities.
Data synthesis We present a systematic review of the literature. The search in five databases (Medline, Embase, Cochrane Database of Systematic Reviews, LILACS and RedALyC) led to 63 published cases from 24 countries, in the 5 continents. The ages of the patients ranged from newborn to 65 years old. The most common agents belong to the Sarcophagidae or Calliphoridae families. Chronic otitis media, previous otic surgical procedures, mental deficit, alcohol or drug abuse, sleeping outdoors, prostration, and malnutrition were predisposing factors. The treatment alternatives are herein discussed.
Conclusion The results highlight the need for monitoring, follow-up and standardization of medical approaches.
Brain Tumor Heterogeneity
Authors: Belsuzarri Telmo Augusto Barba , Neves Maick Willen Fernandes , Costa Otávio Augusto da , Soares Diego Alves , Melo Filho Fernando Antônio de , Guimarães Mariana Mazzuia , Gonçales Tiago Fernandes , Zeviani Wolnei Marques , Araújo João Flávio Mattos 
Published: March 2018

AbstractTumor heterogeneity is the concept that different tumor cells provide distinct biomorphological lesions, gene expressions, proliferation, microenvironment and graduated capacity of metastatic lesions. Brain tumor heterogeneity has been recently discussed about the interesting interaction of chronic inflammation, microenvironment, epigenetics and glioma steam cells. Brain tumors remain a challenge with regards to medication and disease, due to the lack of treatment options and unsatisfactory results. These results might be the result of the brain tumor heterogeneity and its multiple resistance mechanisms to chemo and radiotherapy.