bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound-Guided High Intensity Focused Ultrasound Ablation for Symptomatic Uterine Fibroids: Preliminary Clinical Experience
Authors: Lyon Paul Christopher , Rai Vic , Price Natalia , Shah Aarti , Wu Feng , Cranston David 
Published: June 2019

Abstract
Objective To evaluate the middle-term efficacy and complications of ultrasound-guided high intensity focused ultrasound (USgHIFU) for the treatment of symptomatic uterine fibroids in an NHS population.
Methods A prospective observational single-center study at a single university hospital in Oxford, UK. Patients with symptomatic uterine fibroids who declined standard surgical/radiological intervention and were referred to the HIFU unit were considered for USgHIFU treatment. Clinical evaluation, adverse event monitoring, uterine fibroid symptoms and health-related quality of life questionnaire (UFS-QOL) and contrast-enhanced pelvic magnetic resonance imaging (MRI) were performed before and at regular intervals after treatment to assess patient outcome.
Results 12 of 22 referred patients underwent one session of USgHIFU ablation of 14 fibroids overall and received a two-year follow-up. No serious adverse events were reported, but a second-degree skin burn was observed in one patient who had a surgical scar from a previous caesarean section. Mean symptom severity scores (SSS-QOL) improved significantly from 56.5 ± 29.1 (SD) at baseline to 33.4 ± 23.3 (p < 0.01) at three months, 45.0 ± 35.4 (p < 0.05) at one year and 40.6 ± 32.7 (p < 0.01) at two years post-treatment. The mean non-perfused volume ratio was 67.7 ± 39.0 % (SD) in the treated fibroids (n = 14) within three months of treatment. The mean volume reduction rates of the treated fibroids were 23.3 ± 25.5 % (SD) at 3 months post-treatment (p < 0.01, n = 14), 49.3 ± 23.7 % at 12 months (p < 0.05, n = 8), and 51.9 ± 11.1 % at 24 months (p < 0.005, n = 8).
Conclusion This study demonstrates the clinical efficacy of USgHIFU ablation of uterine fibroids and the low risk of complications. We believe that this noninvasive approach may offer an alternative therapy for women with symptomatic uterine fibroids. While HIFU is fast becoming the standard of care for fibroid ablation in other countries, to our knowledge, this study is the first to present clinical experience of US-guided HIFU ablation of symptomatic uterine fibroids in an NHS population.
Plain Language Summary High intensity focused ultrasound (HIFU) can be used for the noninvasive ablation of symptomatic uterine fibroids, and MR-guided treatment has already gained FDA approval. Ultrasound-guided HIFU has the advantage of offering practicalities in anesthesia and considerable cost-savings over MR-guided treatments. In this prospective study we have demonstrated the middle-term efficacy and favorable safety profile of ultrasound-guided HIFU for the treatment of symptomatic uterine fibroids for the first time in an NHS population.
Molecular Targets Involved in the Neuroprotection Mediated by Terpenoids
Authors: González-Cofrade Laura , de las Heras Beatriz , Apaza Ticona Luis , Palomino Olga M. 
Published: June 2019

AbstractNatural products and their derivatives represent the most consistently successful source of drug leads. Terpenoids, a structurally diverse group, are secondary metabolites widely distributed in nature, endowed with a wide range of biological activities such as antibacterial, anti-inflammatory, antitumoral, or neuroprotective effects, which consolidate their therapeutic value. During the last decades, and taking into consideration the prevalence of aging-related diseases, research activity into the neuroprotective effects of these types of compounds has increased enormously. Several signaling pathways involved in neuroprotection are targets of their mechanism of action and mediate their pleiotropic protective activity in neuronal cell damage. In the present review, molecular basis of the neuroprotection exerted by terpenoids is presented, focusing on preclinical evidence of the therapeutic potential of diterpenoids and triterpenoids on neurodegenerative disorders. By acting on diverse mechanisms simultaneously, terpenoids have been emphasized as promising multitarget agents.
On mixed dynamics of two-dimensional reversible diffeomorphisms with symmetric non-transversal heteroclinic cycles
Authors: Gonchenko S. V. , Gonchenko M. S. , Sinitsky I. O. 
Published: June 2019

Abstract
We consider one-parameter families (general unfoldings) of two-dimensional reversible diffeomorphisms that contain a diffeomorphism with a symmetric non-transversal heteroclinic cycle. We show that in such families there exist Newhouse intervals of parameters such that the values corresponding to the co-existence of infinitely many stable, completely unstable, saddle and symmetric elliptic periodic orbits are generic (that is, they form Baire second-category sets). Also, the closures of the sets of orbits of different types have non-empty intersections.
Instantaneous blow-up versus local solubility of the Cauchy problem for a two-dimensional equation of a semiconductor with heating
Authors: Korpusov M. O. , Panin A. A. 
Published: June 2019

Abstract
We consider the Cauchy problem for a model third-order partial differential equation with non-linearity of the form

. We prove that for

the Cauchy problem in

has no local-in-time weak solution for a large class of initial functions, while for

a local weak solution exists.
Tracking the evolution of CNS remyelinating lesion in mice with neutral red dye
Authors: Baydyuk Maryna , Cha David S. , Hu Jingwen , Yamazaki Reiji , Miller Evan M. , Smith Victoria N. , Kelly Katherine A. , Huang Jeffrey K. 
Published: June 2019

Significance
To develop therapeutic strategies that enhance repair processes during central nervous system (CNS) injury, the molecular and cellular changes occurring at the injury site must be determined. However, precisely isolating the injury site, such as lesions in animal models of demyelination, has been difficult. We developed a simple and powerful method to track and analyze changes that occur within the lesion microenvironment over time. We demonstrated that neutral red-labeled lesions could be selectively isolated and processed for detailed analyses of transcripts, proteins, cell populations, and metabolites. The results of our study can be used to identify molecular pathways that promote CNS repair and the development of therapies to modulate neuroinflammation or enhance regeneration in demyelinating disorders such as multiple sclerosis.
Sfrp4 repression of the Ror2/Jnk cascade in osteoclasts protects cortical bone from excessive endosteal resorption
Authors: Chen Kun , Ng Pei Ying , Chen Ruiying , Hu Dorothy , Berry Shawn , Baron Roland , Gori Francesca 
Published: June 2019

Significance
Cortical bone homeostasis combines periosteal bone formation and endocortical remodeling. Flaws in these processes lead to altered cortical bone mass. Yet, little is known about the regulatory specificities of the endocortical vs. the periosteal surfaces, both critical in determining cortical thickness. We have shown that Pyle’s disease is due to loss-of-function mutations in the Wnt antagonist SFRP4 and that its deletion in mice causes skeletal deformities closely mimicking those seen in Pyle’s disease: cortical bone thinning. Here, we further elucidate the mechanism by which cortical bone is affected and report that both osteoblast- and osteoclast-expressed Sfrp4 regulate osteoclastogenesis and that Sfrp4-dependent suppression of the noncanonical Wnt/Ror2/Jnk cascade in osteoclasts protects cortical bone from excessive endocortical resorption.
Hybridization of singular plasmons via transformation optics
Authors: Yu Sanghyeon , Ammari Habib 
Published: June 2019

Significance
Surface plasmons, which are optical resonances supported by metallic nanostructures, are extremely useful for manipulating light on the nanoscale. However, designing novel plasmonic devices becomes quite challenging when the desired spectral response pattern is highly complex. Here we show that, by developing a theoretical model which combines plasmon hybridization theory with transformation optics, one can control both global and local features of the resonance spectrum in an intuitive way. As an application, we design a plasmonic metasurface whose absorption spectrum can be controlled over an extremely large class of complex patterns through only two structural parameters. Our theoretical model paves the way for the next generation of plasmonic devices, allowing for the efficient design of complex systems.
Noninvasive preimplantation genetic testing for aneuploidy in spent medium may be more reliable than trophectoderm biopsy
Authors: Huang Lei , Bogale Berhan , Tang Yaqiong , Lu Sijia , Xie Xiaoliang Sunney , Racowsky Catherine 
Published: June 2019

Significance
In clinical in vitro fertilization (IVF), the prevailing method for preimplantation genetic testing for aneuploidy (PGT-A) requires biopsying a few cells from the trophectoderm (TE), the lineage that forms the placenta. The test is invasive, requires specialized skills, and suffers from false positives and negatives because chromosome numbers in the TE and the inner cell mass (ICM), which develops into the fetus, are not always the same. Noninvasive PGT-A (niPGT-A), which is based on sequencing DNA released into the culture medium from both TE and ICM, may offer a solution to these problems but has previously had limited efficacy. The present results show improved sensitivity and reliability of niPGT-A, suggesting a potentially superior test for noninvasive and cost-effective PGT-A in clinical IVF.
Calculating non-perturbative quantities through the world-line formalism
Authors: Antonov Dmitry 
Published: June 2019

Abstract
We present two applications of the world-line formalism to the calculation of non-perturbative quantities in QCD. The first quantity is the free energy of the gluon plasma in the high-temperature limit; the second quantity is the pair-production rate in the chromo-electric field of a flux tube. In the first case, where effects of spatial confinement in the dimensionally-reduced 3D Yang-Mills theory are primarily important, we calculate the free-energy density of a gluon propagating in the stochastic background fields through a suitable parametrization of the area-and the perimeter laws of the Wilson loop, which enters the corresponding one-loop effective action. In this way, we find that the order of the leading correction to the Stefan-Boltzmann free energy changes from

O

(
λ
)

for N ∼ 1 to

O

(

λ

3
/
2

)

for N ≫ 1, where λ is the finite-temperature’t Hooft coupling, and N is the number of colors. In the second case, we find that, in the London limit of the dual superconductor, the Schwinger pair-production rate, ∼ e−const·m

2, goes over to e−const·m
. Given that the flux-tube field is static, we find such a conversion of the Gaussian distribution into an exponential one, remarkable.
Modification of D2-line absorption contours of alkali atoms in antirelaxation coated cells
Authors: Tsygankov E A , Fomichev D E , Chuchelov D S , Zibrov S A , Velichansky V L , Yakovlev V P 
Published: June 2019

Abstract
Absorption features in cells with antirelaxation coating in D2 -lines of alkali metal atoms due to the competition of cyclic and open transitions lying within the Doppler contour are studied. In cells of this type ensemble of atoms is optically pumped over all velocities and the entire volume of the cell during the characteristic time T, which noticeably exceeds local pumping times related to resonant atomic velocities. If the frequency scanning T, the retardation effect results in significant distortion of the laser wave absorption contour and to emergence of the hysteresis phenomenon. The developed theory for a realistic scheme of atomic levels with one cyclic and two open transitions describes experimentally observed absorption contours, their dependence on the light power and the frequency scanning direction.
Studies of space charge dominated electron photoemission at PITZ
Authors: Krasilnikov Mikhail , Chen Ye , Stephan Frank 
Published: June 2019

Abstract
Photoemission in modern high brightness electron sources is under studies at the PITZ photo injector. Space charge dominated photoemission in the presence of high RF field at the semiconductor photocathode is studied. By utilizing core and halo particle distributions based on measured radial laser profiles, simulations reproduce the behaviour of the measured emission curves for a wide range of RF gun parameters within the measurement uncertainties for Gaussian laser pulses. But applying this model to the case of long flattop photocathode laser pulses revealed discrepancies between experimental data and simulation results. Corresponding emittance simulations have been compared to measurements for both temporal profiles of the photocathode laser.
Random search for global extremum of a function using Markov chains simulation
Authors: Vladimirova L V , Ovsyannikov D A 
Published: June 2019

Abstract
The problem under study is global extremum search for multiextremal function. Random search method based on Markov chains simulation is used. A comparative analysis of this method with another method – the method of random search for the global extremum with “memory”, using the normal distribution – done.
The control of unprocessed oil stratums debit restoring by method of ultasound influence with well neutron generator
Authors: Berdonosova N A , Bogdanovich B Yu , Dmitriev M S , Zhuyikov Yu F , Ilyinskiy A V , Nesterovich A V , Shikanov A E , Shikanov E A 
Published: June 2019

Abstract
The examples of experimental studies of oil stratum debit restoring by method of ultrasound influence to stratum are given. The method of control of such unprocessed oil stratum restoring is proposed. It uses well neutron generator with vacuum accelerating tube and neutron reagent method with pumping of neutron absorbing salt solution to stratum. The results of its successful testing are presented.
Image Processing System for Early Detection of Cocoa Fruit Pest Attack
Authors: Basri  , Harli  , Indrabayu  , Areni Intan Sari , Tamin Rosmawati 
Published: June 2019

Abstract
Cocoa (Theobroma cacao L.) is one of the leading commodities that developed in quality and quantity. Efforts through socialization and counseling in the field of cocoa cultivation for the farmers are always reminding know the importance of identifying symptoms from pest attacks could earlier makeup so that preventive actions that do not damage the environment or agricultural land. The study aims to create an early detection system based on image processing on symptoms of pest attacks on cocoa fruits. The early detection system involves training the data and test the data as a result of capture pictures of ordinary cocoa fruits and reviews those attacked by pests in real time at the location of cocoa plantations. Image processing techniques are integrated into the application software to be Able to identify the pixel characteristics of capture images of cocoa fruits. The results of the study showed that the ability of the system to detect the symptoms of pests in training the data was 100% and the test of data was 70%. This result showed that the applications could be recommended to be developed on a larger scale so that it will be helpful for cocoa farmers.
A Study of Limited Resources and Security Adaptation for Extreme Area in Wireless Sensor Networks
Authors: Parenreng Jumadi Mabe , Kitagawa Akio , Andayani Dyah Darma 
Published: June 2019

Abstract
WSNs have five main components namely, the sensing device, processor, memory, power supply, and transceiver. The power supply, processor, and memory are the main resources and have limited resources; therefore, resource availability in WSNs must be maintained. With limited resources available, the WSNs is required to be able to work as efficiently as possible, operated in a long time period and secure due to its placement in extreme areas. Another challenge is to choose the WSNs that has short time operation with strong security or long time operation with adaptable security. This article provides limited resource solutions to WSNs whose placement is in extreme areas that are impossible to do maintenances. As a solution, an adaptation approach to resource availability and security is used as offered by the ARSy Framework. For testing, we use components such as Raspberry pi 3 Model B and DS18B20 temperature sensor. The advantage the raspberry pi because its CPU and Memory resources have a large capacity. With these advantages, it is highly manageable, allows to integrate several types of sensors in one raspberry pi unit, and the use of battery resource becomes optional. The battery will be only used based on the design requirements because the battery consumption is wasteful. The result of the research shows performance ARSy framework compared to the system that works without ARSy framework mechanism.
Economic Value of Mangrove Forest in Pannikiang Island, Barru District, South Sulawesi, Indonesia
Authors: Arfan Amal , Sanusi Wahidah , Rakib Muhammad , Taufieq Nur Anny Suryaningsih 
Published: June 2019

AbstractMangrove forest area is a very important area in Pannikiang. Mangrove forests in this area are used by the community as a livelihood. This study wants to learn about the economic valuation of mangrove forests on Pannikiang Island, Makassar. A total of 60 respondents were interviewed in depth. Benefit value, calculated using the value of Direct Use, Indirect Use Value, Option Value, Existence Value, and Total Economic Value. The total economic value of mangrove forests on the Pannikiang Island Rp. 16,155,904,158/year or Rp. 183,007,523,300/ha/year. The patterns and manner of utilization, resource mangrove ecosystem is using gear nets, traps, hooks iron in catching shrimp and crab, develop nursery mangrove system with scraped or directly from the fruit, using gear nets, traps, using an iron hook and set traps crab (rakkang) in catch crabs, catch the bat, found in the mangrove forest, using the net, made bridge length, and the middle of the mangrove forest tower area so that the end could be resting and go up to the tower to see the entire expanse of the forest mangrove Pannikiang Island, wanamina cultivation, which combines farming of fish/shrimp with mangroves.
Phytochemical Test and Toxicity Test for Methanol Extract of Belajang Susu (Scindapsus pictus Hassk.)
Authors: Salempa Pince , Muharram  , Jumadi Oslan 
Published: June 2019

Abstract
Plant Belajang Susu (Scindapsus pictus Hassk.) is a species of the genus Scindapsus including Araceae family that has long been used by Mambi traditional communities as anticancer. Plant that include genus Scindapsus are generally used as ornamental plants, and there are also used as medicinal plants because they contain active compounds and can be antiinflammatory, analgesic, antioxidant and anti-tumor. Methods used included of extraction or maceration, phytochemical test, fractionation and bioactivity test extract with Brine Shrimp Lethality by using Artemia salina. From the results of the phytochemical test it is known that methanol extract of Belajang Susu contain alkaloid and steroid, while toxicity method Brine shrimp lethality test, showed that activity extract methanol Belajang Susu with each LC50 value 1,1365 μg mL−1.
The Influence of Some Plant Extracts that are Potential in the Antichiperglicemia
Authors: Mu’nisa A. , Syamsia  , Rachmawaty  , Muflihunna A. , Sari Dwi Kesuma 
Published: June 2019

Abstract
The underline of this study to investigate the antihyperglycemic effect in mice groups. The plants that have been tested as anti-hyperglycemia are cat root leaves (Acalypha indica), maja leaves (Crescentia cujete L.), and alang-alang plants (Imperata cylindrica). This study used 45 ICR male mice divided into 3 treatment groups, namely the normal mouse group, hyperglycemic mice group, and mice group with the provision of cat leaf extract, maja leaves, and alang-alang plants with a dose of 250 mg kg-1 bw. The results show that the administration of these three plants can reduce the blood glucose levels of mice by 22-27%. The conclusion in this study was that the extract of cat’s root leaves (Acalypha indica), maja leaves (Crescentia cujete L.), and alang-alang plants (Imperata cylindrica) showed an effect as anti-hyperglycemia.
The Effect of Graving Extracts as a Million Grower
Authors: Juliyanti Ayuningrum S. , Jumadi Oslan , Idris Irma Suryani , Kaseng Ernawati S. 
Published: June 2019

Abstract
This research was aimed to determine the effect of algae extract as a driver of maize growth (Zea mays L.) using Randomized Block Design (RAK) with 3 replications. Making of algae-based organic fertilizer that has been done by extract consisting of three types of algae are Eucheuma sp., Sargassum sp., and Ulva sp. Further liquid fertilizer is tested against corn crops (Zea mays L.). Algae extracts are used in plants, either by spraying or by mixing with soil. The observation parameters included stem circumference (cm), leaf chlorophyll content (%), vegetative vegetative biomass (g), corncob (g), corncob (cm), leaf nitrogen (%), and seed nitrogen (%). The use of algae extracts to improve the quality and quantity of maize growth showed the growth of corn crops that tended to be better than controls. Of all existing treatments, algae extract showed Eucheuma sp. Algae extract on the measurement of vegetative biomass, and leaf nitrogen showed the highest yield, Sargassum sp. Algae extract showed the highest result on the measurement of stem circumference and tuna weight, whereas Ulva sp. Algae extract showed the highest yield on measurements of ear and nitrogen grains.
Determination of the Growing Season for Dry Land Agriculture Based on Thornthwaite Method in Bulukumba Regency, South Sulawesi Province
Authors: Umar Ramli , Yusuf Muhammad 
Published: June 2019

Abstract
Drought events in a region are strongly related to the surface water availability and low rainfall. Furthermore, drought conditions impact the threat of food security. Bulukumba Regency in South Sulawesi Province is one of the areas that are prone to drought and the risk of crop failure. Therefore it needs anticipatory action to understand the drought index in this region. This study aims to identify the conditions of drought and agitation in the Bulukumba District of South Sulawesi Province. The results of the identification then became the basis for determining the growing season in various types of dryland agriculture cultivation. This study used the Thornthwaite method with a water balance and drought index approach. The sampling method in this study was purposive sampling. Data collection techniques carried out are observation techniques, laboratory analysis techniques, and documentation techniques. Data processing used quantitative techniques and descriptive approaches. The results of the study show that the growing season in dryland agriculture in November, December, and January based on the availability of water in this region. Conversely, the availability of water is very low in May to September and not appropriate to handling the cultivation.