bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability and Validity of Three Versions of the Brief Fear of Negative Evaluation Scale in Patients With Systemic Sclerosis: A Scleroderma Patient‐Centered Intervention Network Cohort Study
Authors: Fox Rina S. , Kwakkenbos Linda , Carrier Marie‐Eve , Mills Sarah D. , Gholizadeh Shadi , Jewett Lisa R. , Roesch Scott C. , Merz Erin L. , Assassi Shervin , Furst Daniel E. , Gottesman Karen , Mayes Maureen D. , Thombs Brett D. , Malcarne Vanessa L. ,   and the SPIN Investigators
Published: February 2018

ObjectiveFear of negative evaluation is a common concern among individuals with visible differences but has received limited attention in systemic sclerosis (SSc), which can involve substantial changes to appearance. The Brief Fear of Negative Evaluation Scale (BFNE) was specifically designed to evaluate fear of negative evaluation. There are currently 3 versions of the BFNE with strong demonstrated measurement properties: two 8‐item versions (BFNE‐S, BFNE‐8) and one 12‐item version (BFNE‐II). The present study evaluated these versions in SSc, and identified the most appropriate version for use among SSc patients.MethodsParticipants were 1,010 patients with SSc enrolled in the Scleroderma Patient‐Centered Intervention Network cohort. Multiple group confirmatory factor analysis, Cronbach's alpha, and Pearson's product‐moment correlations were used to evaluate structural validity, internal consistency reliability, and convergent and divergent validity, respectively.ResultsConfirmatory factor analysis demonstrated that 1‐factor models fit acceptably well for the 12‐item BFNE‐II, the 8‐item BFNE‐S, and the 8‐item BFNE‐8. Additionally, all Cronbach's alphas demonstrated excellent internal consistency reliability (BFNE‐II = 0.98, BFNE‐S = 0.97, BFNE‐8 = 0.96), and all versions had comparable associations with measures of social anxiety, body‐related attitudes, depression, age, and education.ConclusionPsychometric support was found for all 3 versions of the BFNE, although the longer 12‐item BFNE‐II did not improve measurement compared to the shorter 8‐item versions (BFNE‐S and BFNE‐8). Of these 2, the BFNE‐S has been more widely studied, with strong validity data in a greater number of populations. Therefore, the BFNE‐S is recommended to assess fear of negative evaluation among patients with SSc.
Enantioselective Cyanosilylation of Alkynyl Ketones Catalyzed by Combined Systems Consisting of Chiral Ruthenium(II) Complex and Lithium Phenoxide
Authors: Ohkuma Takeshi , Kurono Nobuhito , Sakaguchi Yusuke , Yamauchi Kohei , Yurino Taiga 
Published: February 2018

AbstractAsymmetric cyanosilylation of alkynyl ketones with the catalyst systems consisting of amino acid/2,2′‐bis(diphenylphosphino)‐1,1′‐binaphthyl (BINAP)/ruthenium(II) complex and lithium phenoxide (Ru⋅Li cat.) was studied. The reaction was conducted in tert‐butyl methyl ether (TBME) at −78 °C with a substrate‐to‐catalyst molar ratio (S/C) as high as 2000. A series of simple and functionalized ketones was converted into the alkynyl tertiary cyanohydrin derivatives in up to 99% ee. Appropriate selection of an amino‐acid ligand of the catalyst according to the substrate structure was crucially important to achieve high enantioselectivity and a wide scope of substrates. Transformation of the chiral cyanohydrin product into a functionalized lactone was also examined.magnified image
Radical Alkyne peri‐Annulation Reactions for the Synthesis of Functionalized Phenalenes, Benzanthrenes, and Olympicene
Authors: Tsvetkov Nikolay P. , Gonzalez‐Rodriguez Edgar , Hughes Audrey , dos Passos Gomes Gabriel , White Frankie D. , Kuriakose Febin , Alabugin Igor V. 
Published: February 2018

AbstractRadical cyclization reactions at a peri position were used for the synthesis of polyaromatic compounds. Depending on the choice of reaction conditions and substrate, this flexible approach led to Bu3Sn‐substituted phenalene, benzanthrene, and olympicene derivatives. Subsequent reactions with electrophiles provided synthetic access to previously inaccessible functionalized polyaromatic compounds.
Predicting the Helical Sense of Poly(phenylacetylene)s from their Electron Circular Dichroism Spectra
Authors: Fernández Berta , Rodríguez Rafael , Rizzo Antonio , Quiñoá Emilio , Riguera Ricardo , Freire Félix 
Published: February 2018

AbstractThe calculated ECD spectrum (time‐dependent density functional theory TD‐DFT) for small oligomers of polyphenylacetylenes (PPAs) show a very good match with the experimental spectra of the PPA polymers, particularly with the first Cotton band associated to the helical sense of the internal polyenic backbone. This has been proven with a series of PPAs representative of cis‐cisoidal, cis‐transoidal, compressed and stretched polyene backbones, with identical or opposite internal/external rotational senses and allows the prediction of the helical sense of the internal helix of a PPA directly from its CD spectra.
Evaluation of the Catalytic Relevance of the CO‐Bound States of V‐Nitrogenase
Authors: Lee Chi Chung , Wilcoxen Jarett , Hiller Caleb J. , Britt R. David , Hu Yilin 
Published: February 2018

AbstractBinding and activation of CO by nitrogenase is a topic of interest because CO is isoelectronic to N2, the physiological substrate of this enzyme. The catalytic relevance of one‐ and multi‐CO‐bound states (the lo‐CO and hi‐CO states) of V‐nitrogenase to C−C coupling and N2 reduction was examined. Enzymatic and spectroscopic studies demonstrate that the multiple CO moieties in the hi‐CO state cannot be coupled as they are, suggesting that C−C coupling requires further activation and/or reduction of the bound CO entity. Moreover, these studies reveal an interesting correlation between decreased activity of N2 reduction and increased population of the lo‐CO state, pointing to the catalytic relevance of the belt Fe atoms that are bridged by the single CO moiety in the lo‐CO state. Together, these results provide a useful framework for gaining insights into the nitrogenase‐catalyzed reaction via further exploration of the utility of the lo‐CO conformation of V‐nitrogenase.
Toward Thiophene‐Annulated Graphene Nanoribbons
Authors: Miao Dandan , Daigle Maxime , Lucotti Andrea , Boismenu‐Lavoie Joël , Tommasini Matteo , Morin Jean‐François 
Published: February 2018

AbstractNarrow thiophene‐edged graphene nanoribbons (GNRs) were prepared from polychlorinated thiophene‐containing poly(p‐phenylene)s using the photochemical, metal‐free cyclodehydrochlorination (CDHC) reaction. 1H NMR and Raman spectroscopy confirmed the structures of the GNRs. The regioselectivity of the CDHC reaction allows the preparation of both laterally symmetrical and unsymmetrical GNRs and, consequently, the modulation of their optical and electronic properties.
Water‐Assisted Size and Shape Control of CsPbBr3 Perovskite Nanocrystals
Authors: Zhang Xiaoyu , Bai Xue , Wu Hua , Zhang Xiangtong , Sun Chun , Zhang Yu , Zhang Wei , Zheng Weitao , Yu William W. , Rogach Andrey L. 
Published: February 2018

AbstractLead‐halide perovskites are well known to decompose rapidly when exposed to polar solvents, such as water. Contrary to this common‐place observation, we have found that through introducing a suitable minor amount of water into the reaction mixture, we can synthesize stable CsPbBr3 nanocrystals. The size and the crystallinity, and as a result the band gap tunability of the strongly emitting CsPbBr3 nanocrystals correlate with the water content. Suitable amounts of water change the crystallization environment, inducing the formation of differently shaped perovskites, namely spherical NCs, rectangular nanoplatelets, or nanowires. Bright CsPbBr3 nanocrystals with the photoluminescence quantum yield reaching 90 % were employed for fabrication of inverted hybrid inorganic/organic light‐emitting devices, with the peak luminance of 4428 cd m−2 and external quantum yield of 1.7 %.
Development of microsatellite markers for the wind cave–associated shrub Lonicera alpigena subsp. glehnii (Caprifoliaceae)
Authors: Miyazaki Taisuke , Kimura Takuma , Kamata Kentaro , Maki Masayuki 
Published: February 2018

Premise of the StudyMicrosatellite markers were developed for the wind cave–associated shrub Lonicera alpigena subsp. glehnii to conduct phylogeographic studies on the species.Methods and ResultsBased on the sequence data obtained by 454 sequencing, a total of 81 primer pairs were designed and 18 successfully amplified the microsatellite regions. These markers were highly variable (i.e., average number of alleles per locus = 6.2 [range = 2–15]; average expected heterozygosity per locus = 0.489 [range = 0.149–0.729]). Cross‐species amplification of the primers was tested in 10 congeneric taxa (L. caerulea var. emphyllocalyx, L. chamissoi, L. chrysantha, L. gracilipes var. glandulosa, L. japonica, L. kurobushiensis, L. morrowii, L. ramosissima, L. sachalinensis, and L. strophiophora), and six to 11 primers amplified the microsatellite markers.ConclusionsThe microsatellite markers developed in this study will be useful for phylogeographic studies and conservation genetics of L. alpigena subsp. glehnii as well as congeneric species.
Characterization and transferability of microsatellites for Gentiana lawrencei var. farreri (Gentianaceae)
Authors: Sun Shan‐Shan , Fu Peng‐Cheng , Cheng Yan‐Wei , Zhou Xiao‐Jun , Han Jian‐Min 
Published: February 2018

Premise of the StudyMicrosatellite markers were developed for a medicinal herb, Gentiana lawrencei var. farreri (Gentianaceae), for the future assessment of population genetic structure and potential hybridization events with related taxa.Methods and ResultsUsing the 454 FLX+ sequencing platform, we obtained 81,717 clean reads with an average length of 291 bp. A total of 3031 primer pairs were designed, and 96 were selected for validation. A set of 20 fluorescently labeled primer pairs was further selected and screened for polymorphisms in three G. lawrencei var. farreri populations and one G. veitchiorum population. Among the four populations, the average number of alleles per locus was 15.2. Finally, a set of 17 unlinked loci were determined to be in Hardy–Weinberg equilibrium after two linked loci were removed.ConclusionsThe identified simple sequence repeat markers will be useful for genetic diversity and evolution studies in G. lawrencei var. farreri and related taxa.
Long‐Term Safety and Efficacy of Belimumab in Patients With Systemic Lupus Erythematosus
Authors: Furie Richard A. , Wallace Daniel J. , Aranow Cynthia , Fettiplace James , Wilson Barbara , Mistry Prafull , Roth David A. , Gordon David 
Published: February 2018

ObjectiveWe undertook this US multicenter continuation study (GlaxoSmithKline study BEL112233; ClinicalTrials.gov identifier: NCT00724867) to assess long‐term safety and efficacy of belimumab in patients with systemic lupus erythematosus (SLE) who completed the Study of Belimumab in Subjects with SLE 76‐week trial (ClinicalTrials.gov identifier: NCT00410384).MethodsPatients continued to receive the same belimumab dose plus standard therapy; patients previously receiving placebo received 10 mg/kg belimumab. The primary outcome measure was long‐term safety of belimumab (frequency of adverse events [AEs] and damage assessed using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI], evaluated every 48 weeks [1 study year]). Other assessments included the SLE Responder Index (SRI), flare rates (using the modified SLE Flare Index [SFI]), prednisone use, and B cell levels.ResultsOf 268 patients, 140 completed the study and 128 withdrew. The mean ± SD score on the Safety of Estrogens in Lupus Erythematosus National Assessment version of the SLE Disease Activity Index (SELENA–SLEDAI) at baseline was 7.8 ± 3.86. The mean ± SD SDI score increased by 0.4 ± 0.68 from its value at baseline (1.2 ± 1.51). The overall incidence of treatment‐related and serious AEs remained stable or declined through study year 7. An SRI response was achieved by 41.9% and 75.6% of patients at the study year 1 and study year 7 midpoints, respectively. At the study year 7 midpoint, relative to baseline, 78.2% had achieved a ≥4‐point reduction in the SELENA–SLEDAI score, 98.4% had no new British Isles Lupus Assessment Group (BILAG) A organ domain score and no more than 1 new BILAG B organ domain score, 93.7% had no worsening in the physician's global assessment of disease activity, 20.6% had experienced ≥1 severe SFI flare, the mean decrease in prednisone dose was 31.4%, and the median change in CD20+ B cell numbers was −83.2%.ConclusionThese long‐term exposure results confirm the previously observed safety and efficacy profiles of belimumab in patients with SLE.
Bedarfsplanung und Grundlagenermittlung für WU‐Betonbauwerke
Authors: Bastert Heinrich , Fingerloos Frank , Kiltz Denis 
Published: February 2018

AbstractBei wasserundurchlässigen Bauwerken aus Beton, sog. WU‐Betonbauwerken, übernimmt die Betonkonstruktion neben der tragenden auch die abdichtende Funktion gegenüber einer Feuchtebeanspruchung von außen. Die WU‐Wanne als im Erdreich eingebettetes wasserundurchlässiges Bauwerk aus Beton hat sich – nicht zuletzt durch Richtlinien, Merkblätter und zahlreiche Fachveröffentlichungen – als bewährte Bauweise etabliert. Daneben haben sich in den letzten Jahren WU‐Dächer als weitere mögliche wasserundurchlässige Betonbauteile immer mehr durchgesetzt.WU‐Betonbauwerke sind komplexe Baukonstruktionen, die eine enge Abstimmung zwischen den Bauherrenwünschen, der Planung und der Bauausführung erfordern. Hieraus ergibt sich, dass bereits bei der Konzeption von WU‐Betonbauwerken die Anforderungen des Bauherrn berücksichtigt werden müssen. Zur systematischen Erfassung dieser Anforderungen bietet sich ein methodisches Vorgehen im Rahmen einer Bedarfsplanung für WU‐Betonbauwerke an, die sich darüber hinaus zur umfassenden Beratung des Bauherrn und zur anschließenden Dokumentation der Planungsziele auf Basis definierter Bauherrenwünsche eignet.
Toward sustainable consumption: Investigating the determinants of green buying behaviour of Indian consumers
Authors: Jaiswal Deepak , Singh Bhagwan 
Published: February 2018

AbstractGreen buying behaviour can stimulate firms and society in the pursuit of sustainability while balancing the demand and supply side of the business cycle with addressing the ecological and social benefits. The objective of this paper is to understand and test the integrative model of green buying behaviour in the Indian and Asian context of sustainable consumption. The model is tested by applying structural equation modeling of path analysis using the total of 410 valid responses. The data were collected from Uttar Pradesh (India) through a structured questionnaire using the purposive convenient sampling. The results validate that “green purchase behaviour” is significantly determined by “green purchase intention,” which in turn significantly and positively influenced by “attitude towards green products.” The results also revealed that the measure of “environmental concern” and “perceived consumer effectiveness” were found to be positive and significant predictor of attitude towards green products, however, “perceived environmental knowledge” was not significantly related to attitude towards green products and perceived consumer effectiveness in the model. The discussion and implications are manifested towards sustainable consumption in the context of emerging target markets.
Green supply chain management and financial performance: The mediating roles of operational and environmental performance
Authors: Feng Mengying , Yu Wantao , Wang Xingyu , Wong Chee Yew , Xu Maozeng , Xiao Zhi 
Published: February 2018

AbstractThis study investigates the mediating effects of environmental and operational performance on the relationship between green supply chain management (GSCM) and financial performance. The proposed relationships are analyzed using survey data from a sample of 126 automobile manufacturers in China. The results suggest that GSCM as an integral supply chain strategy is significantly and positively associated with both environmental and operational performance, which then indirectly leads to improved financial performance. The results indicate the possible complementarity effects between various internal and external GSCM practices.
Perforations and how to manage: The coronary interventionalist and peripheral interventionalist working together for a solution
Authors: Heuser Richard R. 
Published: February 2018

Key Points

Perforations can occur in both peripheral and coronary interventional procedures potentially resulting in severe morbidity
A readily available therapeutic option to treat perforations should be present in every cath lab that does coronary and peripheral procedures
The use of a coagulated thrombus injection can be an effective treatment option, but if a major vessel is affected that must remain patent, one viable option is to administer the patients’ own clotted blood to recanalize the vessel without permanent sequelae
Heparin use for diagnostic cardiac catheterization with a radial artery approach: An international survey of practice patterns
Authors: Bossard Matthias , Lavi Shahar , Rao Sunil V. , Cohen David J. , Cantor Warren J. , Bainey Kevin R. , Valettas Nicholas , Jolly Sanjit S. , Mehta Shamir R. 
Published: February 2018

AbstractObjectivesWe aimed to describe global practice patterns of unfractionated heparin (UFH) use for diagnostic transradial cardiac catheterization.BackgroundThe use of the radial artery approach for cardiac catheterization is increasing globally. Limited contemporary data exist to support the use or optimal dosing of UFH to prevent radial artery occlusion (RAO) and other thromboembolic complications.MethodsWe performed a web‐based international survey of 450 interventional cardiologists from 34 countries. We collected information regarding the experience and use of UFH for diagnostic transradial cardiac catheterization.ResultsThe survey was conducted between June and July 2016 and was completed by 227 (50.4%) interventional cardiologists. Overall, 83.3% performed >75% of their coronary angiograms via a radial approach, with the plurality (41.9%) having 10–20 years of clinical experience. Of all respondents, 7.5% did not use UFH for routine diagnostic transradial heart catheterization. Of the 92.5% who did use UFH, it was preferentially administered intra‐arterially by 60% and intravenously by 40%. The majority (62.6%) of interventionalists used a fixed UFH dose with 5,000 IU being the most common dose (used in 48%). For those using a weight‐based UFH (50 IU/kg) dosing regimen for diagnostic procedures (36.1%), the administered UFH dose ranged from 2,000 up to 10,000 IU.ConclusionsDespite the lack of firm evidence, the majority of interventional cardiologists who participated in the survey use UFH to prevent RAO for diagnostic transradial coronary angiography. However, there exist large practice disparities with regards to dose and route of administration. Given this knowledge gap, a dedicated randomized trial is warranted.
Cost‐Effective Palladium‐Doped Cu Bimetallic Materials to Tune Selectivity and Activity by using Doped Atom Ensembles as Active Sites for Efficient Removal of Acetylene from Ethylene
Authors: Zhang Riguang , Zhao Bo , Ling Lixia , Wang Anjie , Russell Christopher K. , Wang Baojun , Fan Maohong 
Published: February 2018

AbstractThe catalytic activity and selectivity of cost‐effective noble‐metal‐doped common metal materials strongly depend on the doped atom ensemble in specific arrangements to provide active sites. In this study, aiming at insight into the doped atom ensembles as active sites for tuning the selectivity and activity towards the target reaction, different doped noble metal Pd atom ensembles for cost‐effective Pd‐doped Cu catalysts act as active sites to investigate the activity and selectivity towards the efficient removal of acetylene from ethylene by using density functional theory calculations. The results show that an ensemble composed of one surface and its joint sublayer Pd atoms in the Cu catalyst as active sites enhance both the selectivity and activity of C2H4 formation caused by adjusting the catalyst surface electronic structure. Moreover, the surface d‐band center of the Pd‐doped Cu catalyst can act as an effective “descriptor” for the rapid screening of catalytic activity in the design of improved catalysts with the noble‐metal‐doped common metal. Further, the ensemble composed of one surface and its joint sublayer doped Pd atoms as active sites in the cost‐effective Pd‐doped Cu bimetallic catalysts is an efficient approach to finely tune the activity and selectivity towards the efficient removal of acetylene from ethylene.
Conserved Histidine Adjacent to the Proximal Cluster Tunes the Anaerobic Reductive Activation of Escherichia coli Membrane‐Bound [NiFe] Hydrogenase‐1
Authors: Flanagan Lindsey A. , Chidwick Harriet S. , Walton Julia , Moir James W. B. , Parkin Alison 
Published: February 2018

Abstract[NiFe] hydrogenases are electrocatalysts that oxidize H2 at a rapid rate without the need for precious metals. All membrane‐bound [NiFe] hydrogenases (MBH) possess a histidine residue that points to the electron‐transfer iron sulfur cluster closest (“proximal”) to the [NiFe] H2‐binding active site. Replacement of this amino acid with alanine induces O2 sensitivity, and this has been attributed to the role of the histidine in enabling the reversible O2‐induced over‐oxidation of the [Fe4S3Cys2] proximal cluster possessed by all O2‐tolerant MBH. We have created an Escherichia coli Hyd‐1 His‐to‐Ala variant and report O2‐free electrochemical measurements at high potential that indicate the histidine‐mediated [Fe4S3Cys2] cluster‐opening/closing mechanism also underpins anaerobic reactivation. We validate these experiments by comparing them to the impact of an analogous His‐to‐Ala replacement in Escherichia coli Hyd‐2, a [NiFe]‐MBH that contains a [Fe4S4] center.
Seriation, the method out of a chemist's mind
Authors: Tóth Gergely , Amari‐Amir Sasan 
Published: February 2018

AbstractSeriation is the practice of performing row and column permutations on data matrices to reveal clusters and hidden patterns within and between them. Seriation has been a known problem to tackle in the literature for over a century except chemical data where there are a fewer than a handful of researchers who have knowingly worked on this technique. The aim of this paper is to give seriation examples on chemical data and to propose the systematic use of seriation as a possible intuitive tool between data preprocessing and explanatory data analysis. Seriation itself performs the descriptive and exploratory data evaluations at a qualitative level with more limited efficiency than the specialized methods, but it may suggest to use clustering, variable selection, principal component analysis, and modeling. Different databases were used to check the versatility of seriation methods: benchmark ones on iris and wine, radioactivity data of sand mines, coin metal compositions, bioactivity of anticancer compounds, features of essential oils, and a reaction kinetic mechanism of biofuel combustion.