bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Study of Imbibition Characteristics During the Soaking Stage After Fracturing in Tight Reservoirs
Authors: Zhao Hailong , Xu Long , Liu Ziqing , Wu Shanglin , Gong Houjian , Li Yajun , Sun Hai , Dong Mingzhe 
Published: November 2024

ABSTRACTThe soaking stage is vital for oil production after fracturing in tight reservoirs. However, the roles and contributions of spontaneous imbibition (SI) and forced displacement imbibition (FDI) during this stage are poorly understood. This study gave an in‐depth insight on the imbibition characteristics during the soaking stage under non‐zero initial water saturation conditions by static soaking and dynamic waterflooding of the core. The results indicate that the fluid absorbed by SI in the core is short‐ranged. After SI, there is still a substantial amount of remain oil (30.7%) that can be displaced by subsequent FDI. SI considerably drives oil recovery in small pores (10–100 nm), whereas FDI is more effective in large pores (500–1000 nm). Controlling the rate of fracturing water flowing into the matrix from the fracture can enhance the combined effect of SI and FDI. For reservoirs with high initial water saturation, enhancing FDI effect during the soaking stage is favorable for oil production.
Sustainable Hydrogen Storage and Methanol Synthesis Through Solar‐Powered Co‐Electrolysis Using SOEC
Authors: Khan Muhammad Sajid , Abid Muhammad , Chen Chen , Zaini Juliana Hj , Ratlamwala Tahir , Alqahtani Ali Ahmed 
Published: November 2024

ABSTRACTSyngas rich in hydrogen, generated through renewable‐powered co‐electrolysis of water (H2O) and carbon dioxide (CO2) using solid oxide electrolysis cells (SOEC), have gained significant attention due to its high efficiency and conversion rates. This method offers a promising solution for mitigating global warming and reducing CO2 emissions by enabling the storage of intermittent renewable energy. This study investigates solar‐integrated co‐electrolysis of H2O and CO2 via SOEC to produce hydrogen‐rich syngas, which is then utilized for methanol synthesis through a series of heat exchangers and compressors. Parabolic dish solar collectors supply thermal energy, while photovoltaic modules provide electricity for SOEC operation. CO2 from industrial processes is captured and combined with steam at the SOEC inlet for co‐electrolysis. The proposed system is modeled using engineering equation solver software, incorporating mass, energy, and exergy balance equations. The system's performance is analyzed by varying key parameters such as direct normal irradiance, heat exchanger effectiveness, current density, cell temperature, and pressure. The proposed system achieves a solar‐to‐fuel efficiency of 29.1%, with a methanol production rate of 41.5 kg per hour. Furthermore, an economic analysis was conducted to determine the levelized cost of fuel.
Astrocytic GAT‐3 Regulates Synaptic Transmission and Memory Formation in the Dentate Gyrus
Authors: Shen Weida , Chen Fujian , Tang Yejiao , Zhou Wen , Zhao Yulu , Li Xinrui , Dong Jingyin , Zhu Feng , Chen Shishuo , Zeng Ling‐Hui 
Published: November 2024

ABSTRACTGABAergic network activity plays a crucial role in a wide array of physiological processes and is implicated in various pathological conditions. While extensive research has been conducted on how GABAergic network activity modulates both excitatory and inhibitory synaptic transmission in the CA1 region, the mechanisms by which it influences synaptic transmission in the entorhinal cortex‐dentate gyrus (EC‐DG) circuits are still largely unexplored. Using a combination of whole‐cell patch‐clamp recordings, optogenetics, immunohistochemistry, and behavioral assays, we demonstrate that activation of GABA transporter 3 (GAT‐3) in astrocytes triggers an increase in intracellular Ca2+ via the reverse Na+/Ca2+ exchanger. Intriguingly, inhibiting GAT‐3 impedes the GABA‐induced elevation of astrocytic Ca2+ levels, thereby curtailing the subsequent enhancement of synaptic transmission. Additionally, we show that endogenously released GABA from interneurons also modulates synaptic transmission through GAT‐3 in the DG. Crucially, by selectively diminishing astrocytic calcium signals, we observed a concomitant decrease in the GABA‐induced enhancement of synaptic transmission, underscoring the crucial role of astrocytes in this regulatory pathway. Moreover, we found that the activation of GAT‐3 enhances excitatory transmission via presynaptic GluN2B‐containing N‐methyl‐D‐aspartate receptors (GluN2B‐NMDARs) in the DG. Finally, our in vivo experiments demonstrate that inhibiting GAT‐3 adversely affects the formation of contextual fear memory, highlighting its pivotal role in cognitive processing. These findings underscore the significance of astrocytic GAT‐3 in cognitive functions and offer valuable insights into potential therapeutic targets for cognitive impairments, opening new avenues for the treatment of related disorders.
Political Environment, Banking Liquidity, and Banking Crises: A Mediation Analysis From Panel Data
Authors: Attila Joseph 
Published: November 2024

ABSTRACTThe objective of this paper is twofold. (i) First, we examine whether the political environment affect bank liquidity. (ii) Then, we investigate whether the political environment's impact on banking crises is mediated through bank liquidity. Utilizing a panel dataset comprising of more than 140 countries from 1984 to 2017, we find that prolonged tenures of executive leadership correspond to lower banking liquidity. This outcome is probably offset by the finding that countries governed by right‐wing or majority governments tend to exhibit higher levels of bank liquidity. Our analyzes using the Karlson‐Holm‐Breen (KHB) mediation method suggest that the political environment does influence directly banking crises. Tentative results suggest the indirect effect is mediated to some extent through banking liquidity and probably more through credit growth or interaction effects.
Double‐Negative T Cells Promote Liver Fibrosis Progression by Regulating Treg/Th17
Authors: Han Chenyang , Qian Xiaoying , Pei Hongyan , Zhang Caiqun , Wang Jin , Zhou Xiaohong , Li Wenyan , Yang Yi , Wu Shasha 
Published: November 2024

AbstractWe investigated the mechanism whereby double‐negative T cells (DNTs) regulate Treg/Th17 balance to promote the progression of liver fibrosis. Liver fibrosis was induced with carbon tetrachloride (CCl4) in mice. Mouse DNTs were isolated, amplified and injected. The proportions of iTreg (CDF4+CD25+Foxp3+) and Th17 (CD4+IL‐17A+) in peripheral mononuclear cells, spleen and liver were analyzed by flow cytometry, and the cytokine levels were determined through enzyme‐linked immunosorbent assay (ELISA). DNTs could promote the Th17 differentiation and inhibit the iTreg differentiation. The role of DNTs in promoting liver fibrosis progression and tissue inflammation was exerted through activation of IκBa. The use of IL‐17A monoclonal antibody enabled suppression of the DNTs effects, reduction of the Th17 proportion and alleviation of liver fibrosis. Hal could suppress the Th17 differentiation and the effect of DNTs. DNTs can promote the Th17 differentiation through IL‐17A and inhibit iTreg differentiation, thereby facilitating the liver fibrosis progression and microenvironmental inflammation. DNTs are a kind of important immunocytes that promote the liver fibrosis progression.
A GIMEMA survey on therapeutic use and response rates of FLT3 inhibitors in acute myeloid leukemia: Insights from Italian real‐world practice
Authors: Messina Monica , Piciocchi Alfonso , Siena Leonardo M. , Soddu Stefano , Buccisano Francesco , Mecucci Cristina , Martinelli Giovanni , Curti Antonio , Cairoli Roberto , Fazi Paola , Vignetti Marco , Voso Maria Teresa , Venditti Adriano , Candoni Anna 
Published: November 2024

AbstractGiven the limited data on the real‐life therapeutic use of feline McDonough sarcoma (FMS)‐like tyrosine kinase 3 (FLT3) inhibitors in Italy, we surveyed investigators at 59 Italian hematology centers to gain insight into the proportion of acute myeloid leukemia (AML) patients receiving FLT3 inhibitors and we collected data on the efficacy and safety of these agents. The survey results showed that in the real‐life setting the response rate of the 3/7 + midostaurin regimen in newly diagnosed FLT3‐mutated AML and of gilteritinib in the relapsed/refractory AML were comparable to that reported in the registrative clinical trials. The 3/7 + midostaurin treatment resulted in a 63% of complete remission (CR) rates and gilteritinib in a 44% of CR rates. The discontinuation rate of gilteritinib for intolerance or toxicity was low (accounting for 4% of treated cases).
Development of a novel tool for individual treatment trials in mucopolysaccharidosis
Authors: Wiesinger Anna‐Maria , Bigger Brian , Giugliani Roberto , Lampe Christina , Scarpa Maurizio , Moser Tobias , Kampmann Christoph , Zimmermann Georg , Lagler Florian B. 
Published: November 2024

AbstractMucopolysaccharidosis (MPS) encompasses a group of genetic lysosomal storage disorders, linked to reduced life expectancy and a significant lack of effective treatment options. Immunomodulatory drugs could have the potential to be a relevant medical approach, as the accumulation of undegraded substances initiates an innate immune response, which leads to inflammation and clinical deterioration. However, immunomodulators are not licensed for this indication. Consequently, we aim to provide evidence advocating fast access to innovative individual treatment trials (ITTs) with immunomodulatory drugs and high‐quality evaluation of drug effects by implementing a risk–benefit model tailored for MPS. The iterative methodology of our novel decision analysis framework (DAF) involves three key steps: (i) literature review on promising treatment targets and immunomodulators in MPS; (ii) quantitative risk–benefit assessment (RBA) of selected molecules; (iii) assigning phenotypic profiles and quantitative evaluations. The results facilitate a personalized application of the model and are based on published evidence as well as interdisciplinary experts' consensus and patient perspectives. Four promising immunomodulators have been identified: adalimumab, abatacept, anakinra, and cladribine. An improvement in mobility is most likely with adalimumab, while anakinra is anticipated as a treatment of choice for neuronopathic MPS patients. Nevertheless, a comprehensive RBA should always be completed on an individual basis. Our evidence‐based DAF tool for ITTs directly addresses the substantial unmet medical need in MPS and characterizes an initial stride toward precision medicine with immunomodulators.
Do Theoretical Assumptions of Geographic Profiling Hold When Scrutinising Commuter Serial Rape Offenders in South Africa?
Authors: Glass Dion , Herbig Friedo 
Published: November 2024

ABSTRACTGeographic profiling (GP) can be regarded as vital within the apparatus of investigating serial offenders. Since prevailing theories focus on offenders emanating from developed countries, the aim of this study was to examine, amongst others, the uncertainty that exists regarding their relevance in the South African context. This study, therefore, focused on South African commuter serial rapists and, in particular, their correlation with distance decay, the least effort principle, and buffer zones. While the overall data revealed a strong link between theories related to crime pattern, routine activity, awareness, and activity space, theories about distance decay, buffer zones, and the least effort principle had far weaker associations. Fundamentally, the study challenged existing assumptions that a commuter serial rapist profile could not be determined prematurely in an investigation, highlighting the ability to distinguish commuter offenders based on their directional behaviour within their convex hull(s). The research found that understanding these distinctions underscores the need for a theoretical perspective that better grasps the spatial reality of crime in this context.
Effect of drying methods and variety on the chemical composition, functional, and microbial properties of date flour
Authors: Ujong Anim Ekpo , Emelike Nkechi Juliet Tamuno , Ofiks Awajiteleyem , Ohanehi Helen Amarachukwu , Olumide Blessing Akang 
Published: November 2024

AbstractBackgroundDates are highly perishable fruits, and maintaining their quality during storage is essential for both commercial viability and consumer satisfaction. One effective strategy for preserving their nutritional and functional properties is through drying, which reduces moisture content and inhibits microbial growth while concentrating essential nutrients. This study compared the impact of three drying methods (sun drying, hot air oven drying, and cabinet drying) on the chemical, functional, and microbial properties of date flour. The flesh of two date varieties, Amber and Sukkari, was processed by washing, drying at 65°C, milling, and sieving to obtain fine flour, which was then subjected to analysis.ResultsThe results revealed that fat (5.35 ± 0.07%), protein (10.50 ± 0.00%), and crude fiber (8.57 ± 0.59%) contents were higher in hot‐air oven‐dried amber date fruit. Moisture (12.94 ± 0.63%), ash (2.37 ± 0.03%), and vitamin C (0.024 ± 0.00 mg/100 g) contents were reported to be higher in sun‐dried Sukkari date due to the slower drying process and exposure to lower drying temperatures during sun drying, which allows for minimal thermal degradation of heat‐sensitive compounds like vitamin C. Oven‐dried Amber date powder displayed greater water absorption (1.10 mL/g) and solubility (66.60%). In terms of microbial analysis, both hot air oven‐dried Amber and Sukkari dates had the lowest total viable count (1.19 × 105 and 9.45 × 104 CFU/mL, respectively).ConclusionHot air oven drying is a suitable method for drying date fruit as it results in the highest retention of protein, fiber, and ash content while also maintaining low moisture levels, reducing microbial growth, and improving shelf life.
Clinical Phenotypic Characterization of the SLC26A4 Mutation in Pendred Syndrome/Nonsyndromic Enlarged Vestibular Aqueduct
Authors: Zhuang Boxiang , Du Haiqiao , Chen Chenyu , Li Menghua , Kang Shuoshuo , Wang Qian , Wang Shuwei , Guo Weiwei , Lin Chang , Li Jianan , Yang Shiming , Wang Rong 
Published: November 2024

ObjectiveTo summarize the Solute Carrier Family 26 Member 4 (SLC26A4) mutations and clinical phenotypic characteristics of patients with Pendred syndrome/nonsyndromic enlarged vestibular aqueduct (PS/NSEVA).DesignA retrospective cohort study for the Chinese population was performed to analyze the hearing test results of 406 patients with PS/NSEVA who had a SLC26A4 mutation and the relationship between inner ear imaging and audiology.ResultsThere was a significant difference in the mean hearing threshold in patients with biallelic mutations (M2), monoallelic mutations (M1), and nonallelic mutations (M0) and between patients with isolated vestibular aqueduct enlargement (IEVA) and patients with IEVA combined with Mondini malformation. There was no significant difference between patients with different gene mutation types or different sexes, or between the width of the vestibular aqueduct (VA) and the mean hearing threshold. The degree of hearing loss was linearly correlated with age.ConclusionsWe propose that the presence and absence of SLC26A4 mutation, whether combined with Mondini malformation and patient age, are essential factors affecting the degree of hearing loss in the Chinese population. However, the number and type of mutations, degree of VA expansion, and sex of the patients did not affect the clinical audiological phenotype.Level of Evidence3 Laryngoscope, 135:848–856, 2025
Collaborating for growth: Insights from Publisherspeak UK 2024, a scholarly publishing community gathering – part 2
Authors: Venkataramani Ravi , Mahadevan Sowmya , Ramkumar Arun , De Boer Jason , Krishnan Janani , Russell Louise , Anderton Sophia , Burley Caroline , Cockburn Emily , Kelly Joe 
Published: November 2024

Key points
Publisherspeak UK 2024, sponsored by Kriyadocs, fostered collaboration among stakeholders to address scholarly publishing challenges.
The environmental sustainability session focused on balancing economic priorities with environmental goals to reduce carbon footprints.
The session on research communities focused on strategies to enhance stakeholder engagement and support participation in the publishing ecosystem.
Delegates discussed challenges in balancing institutional and individual priorities, focusing on strategies that promote inclusivity and diversity.
On building community in scholarly publishing: Modern ambitions and actions inspired by ancient wisdoms
Authors: Henry Christie 
Published: November 2024

Key points
Community ecology: there are parallels between ecological communities and publishing communities, each flourishes with interconnectedness and reciprocity.
People‐centric approach: the people of publishing are essential to building and maintaining publishing communities, especially in the age of AI and global fragmentation.
Books as community builders: books have historically brought people together and continue to do so, from ancient times to modern book clubs and social media.
Leadership and community building: building community takes intention, time and skills, and publishing could benefit from prioritizing community building skills in publishing leadership roles and job descriptions.
Fully Conjugated Microporous Polymers as Metal‐Free Heterogeneous Photocatalysts for Organic Transformations
Authors: Liu Yuanbo , Lu Yi , Hou Yuxin , Xiao Xiao , Yue Huijuan , Liu Xiaoming 
Published: November 2024

AbstractPhotoactive conjugated microporous polymers (CMPs) have recently received huge attention in photocatalytic organic transformations owing to their adjustable structure and functionality. However, commonly reported CMPs are synthesized through metal catalyzed coupling reactions, which require complicated product separation and result in increased costs. In this study, two sp2 carbon‐linked CMPs are constructed by organic base induced Knoevenagel reaction using 2,6‐dimethylbenzo[1,2‐d:4,5‐d']bisoxazole and aromatic polyaldehydes as co‐monomers. The new benzobisoxazole‐based polymer materials feature fully π‐conjugated skeleton with broad visible‐light absorption, permanent porosity as well as outstanding stability. Importantly, they can effectively induce many organic reactions such as C‐3 thiocyanation of indoles under visible‐light illumination and show broad substrate applicability and superior recyclability.
Nicotinamide mononucleotide protects STAT1 from oxidative stress‐induced degradation to prevent colorectal tumorigenesis
Authors: Li Ting , Luo Chengting , Liu Zongyuan , Li Jinyu , Han Meng , Zhang Ran , Chen Yuling , Deng Haiteng 
Published: November 2024

AbstractColitis, accompanied by the accumulation of reactive oxygen species (ROS) in the intestinal tract, is a risk factor for colorectal cancer (CRC). Our previous studies indicate that nicotinamide mononucleotide (NMN) replenishment reduces chronic inflammation. In this study, we confirm that NMN supplementation reduces inflammatory cytokine levels and oxidative tissue damage in an azoxymethane/dextran sulfate sodium (AOM/DSS)‐induced colitis‐associated cancer (CAC) model. Mice treated with NMN developed fewer colon tumors than untreated animals under the same AOM/DSS treatment conditions. Quantitative proteomic analysis revealed a decrease in signal transducer and activator of transcription 1 (STAT1) expression in the CAC model. We demonstrate that STAT1 overexpression induces G1 arrest by downregulating CDK6 expression and suppressing tumor cell proliferation and migration. Of note, H2O2 induced trioxidation of the STAT1 protein and promoted its degradation, which was partially reversed by NMN supplementation. Upon H2O2 treatment, Cys155 in STAT1 was oxidized to sulfonic acid, whereas the mutation of Cys155 to alanine abolished ROS‐mediated STAT1 degradation. These results indicate that oxidative stress induces STAT1 degradation in tumor cells and possibly in CAC tissues, whereas supplementation with NMN protects STAT1 from oxidation‐induced degradation and prevents tumorigenesis. This study provides experimental evidence for the development of NMN‐mediated chemoprevention strategies for CRC.
Analysis of Dynamic Problems in Fully Saturated Porous Media Using an Embedded Velocity Integration Formulation With an Adaptive Runge–Kutta Method
Authors: Sunten J. , Schwarz A. , Bluhm J. , Schröder J. 
Published: November 2024

ABSTRACTThis contribution presents a dynamic binary Theory of Porous Media (TPM) model using an embedded velocity integration (EVI) formulation. The inclusion of dynamic effects into a TPM model leads to an increase in the number of unknown quantities and may also limit the choice of fitting time integration methods. By switching to a velocity formulation the amount of unknown quantities is kept to a minimum and the necessity of a time integration scheme being able to produce a second material time derivative is avoided. The used EVI formulation was verified and its advantage concerning computational time was shown by a comparison to a classic approach by Diebels and Ehlers. Both approaches were simulated with an adaptive, embedded, stiffly accurate, explicit, singly, diagonally implicit Runge–Kutta (saESDIRK) time integration method to decrease the computational time even more.
Early Septoplasty Versus Closed Reduction for Acute Nasoseptal Fracture: A Systematic Review and Meta‐analysis
Authors: Wadsworth Elizabeth W. , Duckett Kelsey A. , Nguyen Shaun A. , Patel Krishna G. 
Published: November 2024

AbstractObjectiveAccurate management of acute nasoseptal fractures can mitigate cosmetic and functional complications. There is a lack of consensus on the ideal approach to manage acute nasoseptal fractures, which are often addressed with closed nasal and/or septal reduction (CN/SR) but sometimes addressed using an open approach with septoplasty. We aimed to systematically assess and compare outcomes of CN/SR versus open approaches to treat acute nasoseptal fractures.Data SourcesPubMed, Scopus, and CINAHL.Review MethodsStudies evaluating outcomes of adults with acute nasoseptal fractures treated within 3 weeks of injury with either CN/SR or open approach were included. Meta‐analysis was performed to examine the pooled frequency of complications including persistent obstruction, cosmetic deformity, and need for revision surgery.ResultsOf 1630 unique articles identified, 27 were included (63% retrospective, 29.6% prospective, 7.4% randomized controlled trial). Data included 1117 patients (n = 712 CN/SR, n = 423 open approach), with a mean age of 30.5 years. Patients who underwent CN/SR only were more likely to experience persistent obstruction compared to patients who underwent open approach (22.2% [95% confidence interval, CI, 8.7%‐39.5%] vs 5.9% [95% CI, 2.4%‐10.7%], P < .0001). Patients who underwent CN/SR were more likely to require revision surgery within 3 years (30.9% [95% CI, 15.8%‐48.4%] vs 6.0% [95% CI, 3.3%‐9.9%], P < .0001.ConclusionPatients with nasoseptal fractures who underwent open septoplasty in the acute period were less likely to experience complications. Prospective trials are needed to confirm results of this meta‐analysis.