bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disorganisation, thought disorder and socio-cognitive functioning in schizophrenia spectrum disorders
Authors: de Sousa Paulo , Sellwood William , Griffiths Martin , Bentall Richard P. 
Published: August 2018

BackgroundPoor social cognition is prevalent in schizophrenia spectrum disorders. Some authors argue that these effects are symptom-specific and that socio-cognitive difficulties (e.g. theory of mind) are strongly associated with thought disorder and symptoms of disorganisation.AimsThe current review tests the strength of this association.MethodWe meta-analysed studies published between 1980 and 2016 that tested the association between social cognition and these symptoms in schizophrenia spectrum disorders.ResultsOur search (PsycINFO, MEDLINE and Web of Science) identified 123 studies (N= 9107). Overall effect size asr= −0.313, indicating a moderate association between symptoms and social cognition. Subanalyses yielded a moderate association between symptoms and theory of mind (r= −0.349) and emotion recognition (r= −0.334), but smaller effect sizes for social perception (r= −0.188), emotion regulation (r= −0.169) and attributional biases (r= −0.143).ConclusionsThe association is interpreted within models of communication that highlight the importance of mentalisation and processing of partner-specific cues in conversational alignment and grounding.Declaration of interestsNone.
Effects of Altering Levothyroxine Dose on Energy Expenditure and Body Composition in Subjects Treated With LT4
Authors: Samuels Mary H , Kolobova Irina , Niederhausen Meike , Purnell Jonathan Q , Schuff Kathryn G 
Published: August 2018

Abstract

Background
It is unclear whether variations in thyroid status within or near the reference range affect energy expenditure, body mass, or body composition.

Methods
138 subjects treated with levothyroxine (LT4) for hypothyroidism with normal TSH levels underwent measurement of total, resting, and physical activity energy expenditure; thermic effect of food; substrate oxidation; dietary intake; and body composition. They were assigned to receive an unchanged, higher, or lower LT4 dose in randomized, double-blind fashion, targeting one of three TSH ranges (0.34 to 2.50, 2.51 to 5.60, or 5.61 to 12.0 mU/L). The doses were adjusted every 6 weeks to achieve target TSH levels. Baseline measures were reassessed at 6 months.

Results
At study end, the mean LT4 doses and TSH levels were 1.50 ± 0.07, 1.32 ± 0.07, and 0.78 ± 0.08 µg/kg (P &lt; 0.001) and 1.85 ± 0.25, 3.93 ± 0.38, and 9.49 ± 0.80 mU/L (P &lt; 0.001), respectively, in the three arms. No substantial metabolic differences in outcome were found among the three arms, although direct correlations were observed between decreases in thyroid status and decreases in resting energy expenditure for all subjects. The subjects could not ascertain how their LT4 dose had been adjusted but the preferred LT4 dose they perceived to be higher (P &lt; 0.001).

Conclusions
Altering LT4 doses in subjects with hypothyroidism to vary TSH levels in and near the reference range did not have major effects on energy expenditure or body composition. Subjects treated with LT4 preferred the perceived higher LT4 doses despite a lack of objective effect. Our data do not support adjusting LT4 doses in patients with hypothyroidism to achieve potential improvements in weight or body composition.
Time to Separate Persistent From Recurrent Differentiated Thyroid Cancer: Different Conditions With Different Outcomes
Authors: Sapuppo Giulia , Tavarelli Martina , Belfiore Antonino , Vigneri Riccardo , Pellegriti Gabriella 
Published: August 2018

Abstract

Context
Differentiated thyroid cancer (DTC) has an excellent prognosis, but up to 20% of patients with DTC have disease events after initial treatment, indistinctly defined as persistent/recurrent disease.

Objective
To evaluate the prevalence and outcome of “recurrent” disease (relapse after being 12 months disease-free) compared with “persistent” disease (present ab initio since diagnosis).

Design
Retrospective analysis of persistent/recurrent disease in patients with DTC (1990 to 2016) with 6.5 years of mean follow-up.

Setting
Tertiary referral center for thyroid cancer.

Patients
In total, 4292 patients all underwent surgery ± 131I treatment of DTC.

Main Outcome Measures
DTC cure of disease persistence or recurrence.

Results
A total of 639 of 4292 (14.9%) patients had disease events after initial treatment, most (498/639, 78%) with persistent disease and 141 (22%) with recurrent disease. Relative to patients with recurrent disease, patients with persistent disease were significantly older (mean age 46.9 vs 45.7 years) and with a lower female to male ratio (1.9/1 vs 4.8/1). Moreover, in this group, structured disease was more frequent (65.7% vs 41.1%), and more important, distant metastases were significantly more frequent (38.4% vs 17.0%). At multivariate analysis, male sex (OR = 1.7), age (OR = 1.02), follicular histotype (OR = 1.5), T status (T3; OR = 3), and N status (N1b; OR = 7.7) were independently associated with persistent disease. Only the N status was associated with recurrent disease (N1b; OR = 2.5).

Conclusions
In patients with DTC not cured after initial treatment, persistent disease is more common and has a worse outcome than recurrent disease. Postoperative status evaluated during first-year follow-up may have important clinical implications for planning tailored treatment strategies and long-term follow-up procedures.
MicroRNA-dependent regulation of Hox gene expression sculpts fine-grain morphological patterns in a Drosophila appendage
Authors: Kaschula Richard , Pinho Sofia , Alonso Claudio R. 
Published: August 2018

ABSTRACT
Disruptions of normal Hox gene expression can lead to severe morphological defects, revealing a link between the regulation of Hox expression and pattern formation. Here, we explore these links, focusing on the impact of microRNA regulation on the expression of the Drosophila Hox gene Ultrabithorax (Ubx) during haltere development. Through a combination of bioinformatic and transcriptomic analyses, we identify the miR-310/313 cluster (miR-310C) as a candidate regulator of Ubx. Several experiments confirm this. First, miR-310C and Ubx protein show complementary expression patterns in haltere imaginal discs; second, artificial activation of miR-310C expression in haltere discs leads to Ubx-like phenotypes. Third, expression of a fluorescent reporter bearing Ubx 3′UTR sequences is reduced when co-expressed with miR-310C. Fourth, deletion of miR-310C leads to Ubx upregulation and changes the array of mechanosensory sensilla at the base of the haltere. Fifth, an artificial increase of Ubx levels within the miR-310C expression domain phenocopies the mechanosensory defects observed in miR-310C mutants. We propose that miR-310C-mediated repression delimits Ubx fine-grain expression, contributing to the sculpting of complex morphologies in the Drosophila haltere with implications for flight control. Our work reveals a novel role of microRNA regulation in the control of Hox gene expression with impact on morphology.
Pitx2 maintains mitochondrial function during regeneration to prevent myocardial fat deposition
Authors: Li Lele , Tao Ge , Hill Matthew C. , Zhang Min , Morikawa Yuka , Martin James F. 
Published: August 2018

ABSTRACT
Loss of the paired-like homeodomain transcription factor 2 (Pitx2) in cardiomyocytes predisposes mice to atrial fibrillation and compromises neonatal regenerative capacity. In addition, Pitx2 gain-of-function protects mature cardiomyocytes from ischemic injury and promotes heart repair. Here, we characterized the long-term myocardial phenotype following myocardial infarction (MI) in Pitx2 conditional-knockout (Pitx2 CKO) mice. We found adipose-like tissue in Pitx2 CKO hearts 60 days after MI induced surgically at postnatal day 2 but not at day 8. Molecular and cellular analyses showed the onset of adipogenic signaling in mutant hearts after MI. Lineage tracing experiments showed a non-cardiomyocyte origin of the de novo adipose-like tissue. Interestingly, we found that Pitx2 promotes mitochondrial function through its gene regulatory network, and that the knockdown of a key mitochondrial Pitx2 target gene, Cox7c, also leads to the accumulation of myocardial fat tissue. Single-nuclei RNA-seq revealed that Pitx2-deficient hearts were oxidatively stressed. Our findings reveal a role for Pitx2 in maintaining proper cardiac cellular composition during heart regeneration via the maintenance of proper mitochondrial structure and function.
Spontaneous HTLV-1 transcription is accompanied by distinct epigenetic changes in the 5′ and 3′ long terminal repeats
Authors: Miura Michi , Miyazato Paola , Satou Yorifumi , Tanaka Yuetsu , Bangham Charles R.M. 
Published: August 2018

Background:The human retrovirus HTLV-1 inserts the viral complementary DNA of 9 kb into the host genome. Both plus- and minus-strands of the provirus are transcribed, respectively from the 5′ and 3′ long terminal repeats (LTR). Plus-strand expression is rapid and intense once activated, whereas the minus-strand is transcribed at a lower, more constant level. To identify how HTLV-1 transcription is regulated, we investigated the epigenetic modifications associated with the onset of spontaneous plus-strand expression and the potential impact of the host factor CTCF.Methods:Patient-derived peripheral blood mononuclear cells (PBMCs) and in vitro HTLV-1-infected T cell clones were examined. Cells were stained for the plus-strand-encoded viral protein Tax, and sorted into Tax+and Tax–populations. Chromatin immunoprecipitation and methylated DNA immunoprecipitation were performed to identify epigenetic modifications in the provirus. Bisulfite-treated DNA fragments from the HTLV-1 LTRs were sequenced. Single-molecule RNA-FISH was performed, targeting HTLV-1 transcripts, for the estimation of transcription kinetics. The CRISPR/Cas9 technique was applied to alter the CTCF-binding site in the provirus, to test the impact of CTCF on the epigenetic modifications.Results:Changes in the histone modifications H3K4me3, H3K9Ac and H3K27Ac were strongly correlated with plus-strand expression. DNA in the body of the provirus was largely methylated except for the pX and 3′ LTR regions, regardless of Tax expression. The plus-strand promoter was hypomethylated when Tax was expressed. Removal of CTCF had no discernible impact on the viral transcription or epigenetic modifications.Conclusions:The histone modifications H3K4me3, H3K9Ac and H3K27Ac are highly dynamic in the HTLV-1 provirus: they show rapid change with the onset of Tax expression, and are reversible. The HTLV-1 provirus has an intrinsic pattern of epigenetic modifications that is independent of both the provirus insertion site and the chromatin architectural protein CTCF which binds to the HTLV-1 provirus.
Greedy-Like Algorithms for Dynamic Assortment Planning Under Multinomial Logit Preferences
Authors: Aouad Ali , Levi Retsef , Segev Danny 
Published: August 2018

We study the joint assortment planning and inventory management problem, where stock-out events elicit dynamic substitution effects, described by the multinomial logit (MNL) choice model. Special cases of this setting have been extensively studied in recent literature, notably the static assortment planning problem. Nevertheless, to our knowledge, the general formulation is not known to admit efficient algorithms with analytical performance guarantees before this work, and most of its computational aspects are still wide open.In this paper, we devise what is, to our knowledge, the first provably good approximation algorithm for dynamic assortment planning under the MNL model. We derive a constant-factor guarantee for a broad class of demand distributions that satisfy the increasing failure rate property. Our algorithm relies on a combination of greedy procedures, where stocking decisions are restricted to specific classes of products and the objective function takes modified forms. We demonstrate that our approach substantially outperforms state-of-the-art heuristic methods in terms of performance and speed, leading to an average revenue gain of 4% to 12% in computational experiments. In the course of establishing our main result, we develop new algorithmic ideas that may be of independent interest. These include weaker notions of submodularity and monotonicity, shown sufficient to obtain constant-factor worst-case guarantees, despite using noisy estimates of the objective function.
Improving end-of-life care in an intensive care unit: a collaborative quality improvement project
Authors: Le François Lisa , Tapp Diane 
Published: August 2018

Background: The shift from curative to palliative care is one of the most challenging situations in intensive care units. Aims: The purpose of this collaborative project was to develop and implement a pilot intervention aimed at improving end-of-life care for patients in an open intensive care unit in Quebec City, Canada. Methods: Individual and group interviews were first conducted to identify strengths and needs for improvement in care. After the main needs for improvement were determined, interventions were implemented in a concerted manner. These included training in end-of-life care as well as the adaptation of tools to promote communication with the patient and his or her family, or to facilitate interdisciplinary work. Results: Preliminary results obtained through individual interviews indicate participant satisfaction with the project, but additional data need to be gathered to evaluate improvements in practice. Conclusions: Other collaborative quality improvement projects need to be implemented to improve end-of-life practices in intensive care units.
Pemodelan dan Analisis Perilaku Balok Beton Bertulang yang Berbeda Diameter Akibat Variasi Tata Letak Tulangannya
Authors: Suku Yohanes Laka 
Published: August 2018

Analysis of the effect of the layout of reinforcement in reinforced concrete beams with different diameters to understand behavior and layout position of reinforcement produces the maximum of load capacity and ductility. Modeling and analysis using ANSYS program, the experimental test beam type OA1 and A1 from the University of Toronto (Vichio & Shim, 2004) was used as a benchmark and models which varies in layout of reinforcement. The number of models analyzed is a total of fourteen models consisting of seven models without stirrups and seven with stirrups. Beam behavior observed in the form of load capacity, deflection, ductility, stiffness and crack patterns. Results showed that: the layout of reinforcement affects the behavior of reinforced concrete beam; on the same width of reinforcedment, one layer reinforcement has greater load capacity and rigidity but smaller ductility than two layers; the layout of reinforcement in general does not affect the pattern of cracks; the collapse of the beam without stirrups is caused by the diagonal tension and the beam with stirrups by shear and rupture due to the press; the layout of reinforcement produces the largest load capacity and ductility of the largest is model OA1 and OA1,4 on the beams without stirrups and models A1 and A1,5 on beam with stirrups.
Analisis Ketahanan Gempa Rumah Tembokan Beton Bertulang di Perumahan Graha Arradea
Authors: Yoresta Fengky Satria 
Published: August 2018

The concept of earthquake resistant houses is basically that all building components must be well tied each other. In addition, quality of materials and workmanship must also be good so as to produce a strong building when receiving shocks. This study aims to determine whether houses in Perumahan Graha Arradea (Tahap 3 in Ciherang Village, Dramaga Subdistrict, Bogor District - West Java are built following the design principles of earthquake resistant houses. The research is conducted by observing the construction process at the location. Every stage of the construction process is recorded using a digital camera (Sony Cyber-shot DSC-W730). Interviews are also conducted on related parties to obtain accurate informations. The results conclude that the houses that are built have not met minimum requirements for design of earthquake resistant masonry houses with reinforced concrete frame. In addition to quality of some materials that have not met minimum requirements, the quality of workmanship of building component is also still low. The ties of all building components have not been properly connected.
Evaluasi Kinerja Campuran Beraspal dengan Bitumen Hasil Ekstraksi Penuh dari Asbuton
Authors: Suaryana Nyoman , Susanto Iwan , Ronny Yohannes , Sembayang Ida Rumkita 
Published: August 2018

Asbuton is a natural rock asphalt that can be found on the island of Buton in Southeast Sulawesi province, has a large deposits but not yet well utilized. This research aims to find out the performance of asphalt mixtures AC-WC (Asphaltic Concrete Wearing Course) and HRS-WC (Hot Rolled Sheet Wearing Course) using bitumen results from full extraction of asbuton. The research was done by experimental methods through laboratory tests then its performance was compared to convensional mixtures using asphalt oil with penetration grade of 60. The results obtained showed that the bitumen of asbuton did not meet the specification of bitumen based on penetration grade. Characteristics of hot mixture asphalt using bitumen of asbuton showed better performance in terms of the Marshall stability namely 1871 kg higher than the convensional hotmixture of asphalt, with 1100 kg for AC-WC and 1241.9 kg compared with 1094 kg for HRS-WC. In addition, the results of deformation resistance tests showed asphalt mix with pure asbuton more resistant to rutting shown by higher dynamic stability value namely 4200 track/mm compared with 492 track/mm for AC-WC and 2739 track/mm compared with 325 track/mm. The modulus resilient value of mix with pure asbuton is also higher at temperature of 25°C and relatively the sameat temperatures of 35°C and 45°C. While the resistance of fatigue for AC-WC and HRS-WC on the test tensile strain of 150 µs were relatively the same as hotmix asphalt using asphalt oil penetration grade of 60, but on test of a larger tensile strain has worse fatigue resistance, especially for AC-WC.
Faktor yang Mempengaruhi Keberhasilan Penerapan Teknologi Bidang Jalan dengan Kontrak Rancang Bangun
Authors: Hendrawan Hendra 
Published: August 2018

Research and development in the roads sector is one of the coaching tasks of roads authority. To disseminate the results of research or technology that has been developed required the transfer of technology which one of them through technology implementation project. In the Year 2015-2017 Institute of Road Engineering has carried out the technology transfer process through limited project of implementation technology by using Design and Build contract. In the implementation project there are some constraints or factors that affect the implementation performance so that the resulting output is not optimal. The purpose of the study is to identify the critical determinants of project success of technology implementation with Design and Build contract and to give weighting. The method used in the study is descriptive qualitative analysis using data collection tools in the form of interviews and questionnaires to further analyzed by Analytical Hierarchy Process method. The results of the study showed that the factors that affect the successful of implementation technology projects is qualification of providers. The sub aspect that is considered has big influence is the financial ability for the qualification aspect, and the basic knowledge to the technology developed for technical aspect.
PENGARUH FLUKTUASI INDUSTRIALISASI TERHADAP KAPABILITAS MASYARAKAT PEDESAAN DI MAGELANG: PERSPEKTIF PERENCANAAN WILAYAH
Authors: Pramono Retno Widodo Dwi 
Published: August 2018

Industrialisasi sebagai pemicu transformasi struktur ekonomi, sangat penting bagi proses perkembangan wilayah. Namun, industrialisasi dapat mengalami fluktuasi. Wilayah yang bergantung pada investasi luar, sering mengalami de-industrialisasi akibat migrasi industri ke wilayah yang dianggap lebih menguntungkan, misalnya karena tenaga kerja yang lebih murah dan pasar yang sedang berkembang. Bagaimana akibat perkembangan industrialisasi dan de-industrialisasi pada masyarakat lokal yang agraris? Tulisan ini bertujuan untuk menjawab pertanyaan tersebut dari perspektif perencanaan wilayah. Dengan mengambil kasus pada 2 kecamatan di Magelang dan berdasarkan data series dari tahun 1970-an hingga 2010 serta observasi investigatif secara langsung ke masyarakat, penelitian mengungkap akibat positif dan negatif dari perkembangan industri di wilayah ini, dan sisi positif maupun negatif dari fase de-industrialisasi. Pada masa perkembangan industri, hal yang paling positif adalah meningkatnya rasio lahan per petani yang memberi peluang bagi unit usaha petani untuk meningkatkan skala ekonominya melalui sewa-menyewa lahan. Temuan lain yang menarik adalah de-industrialisasi Industri skala menengah dan besar yang investasinya dari luar, memicu re-industrialisasi oleh masyarakat lokal dalam bentuk pertumbuhan industri rumah tangga. Dari tulisan ini, dalam melakukan tugasnya, perencana wilayah harus mengantisipasi dinamika seperti arahan alokasi penggunaan lahan serta manajemen pemanfaatanya.
Preservation of ancient DNA in human bones from the eneolithic and Bronze Age kurgan cemeteres in Yampil region, Ukraine
Authors: Chyleński Maciej , Juras Anna , Żurkiewicz Danuta , Jankowski Michał , Włodarczak Piotr 
Published: August 2018

Abstract
Ancient DNA was analyzed in altogether 28 Late Eneolithic and Bronze Age human skeletons form 4 sites in southern Ukraine. More than 0,3% of human DNA was preserved only in 13 skeletons. The results of our analyses provide evidence that recovery of DNA molecules suitable for genetic analyses is more dependent on the specificity of the archaeological site and is not strongly correlated with particular environmental factors.
Builders and Users of Ritual Centres, Yampil Barrow Complex: Studies of Diet Based on Stable Carbon and Nitrogen Isotope Composition
Authors: Goslar Tomasz , Jankowski Michał , Kośko Aleksander , Lityńska-Zając Maria , Włodarczak Piotr , Żurkiewicz Danuta 
Published: August 2018

Abstract
The paper presents δ13C and δ15N isotope content measurements in human bones from 16 graves, being part of the Yampil Barrow Complex. From the results, conclusions may be drawn about the diet of barrow builders and users. It was based on vegetable foodstuffs and characterised by a varied share of terrestrial animal meat, depending on the period. High δ13C values suggest a share of C4-type plants in the diet, possibly millet.
Barrow Culture Textiles and Mats in the Middle Dniester Area
Authors: Kałużna-Czaplińska Joanna , Rosiak Angelina , Sikorski Andrzej , Żurkiewicz Danuta 
Published: August 2018

AbstractThe article describes an attempt to identify the raw material of the organic layers - mats identified within the roofs and floors of the graves in the Yampil Barrow Cemetery Complex. The use of gas chromatography and infrared spectroscopy combined with microscopic analysis of the extracted “mat” sections significantly supplements our knowledge in the field of weaving of the studied communities.