bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Prognostic Factors in Colorectal Cancer
Authors: Орлова Рашида Вахидовна , Иванова Анастасия Константиновна , Раскин Григорий Александрович , Кутукова Светлана Игоревна 
Published: December 2024

Введение. Колоректальный рак занимает лидирующие позиции в структуре онкологической заболеваемости. В результате онкоскрининга диагноз ставится на более ранних стадиях, и чаще пациентам стала проводиться адъювантная химиотерапия. В настоящее время имеются известные факторы прогноза, влияющие на включение в план лечения адъювантной химиотерапии, однако они не включают биологические и молекулярно-генетические особенности опухоли. Возможно, поиск новых прогностических факторов приведет к изменению парадигмы лечения больных с колоректальным раком.
Цель. Ооптимизация выбора адъювантной химиотерапии путем оценки влияния совокупности имеющихся факторов прогноза и дополнительных (индекс пролиферации Ki67, KRAS мутация, экспрессия хемокиновых рецепторов) факторов на безрецидивную выживаемость у пациентов с РОК после радикального хирургического лечения.
Материалы и методы. В исследование было включено 113 пациентов с диагнозом рак ободочной кишки II (группа А) или III стадии (группа В) после проведенного хирургического лечения. Всем пациентам было проведено лечение по имеющимся на тот момент стандартам, так пациентам в группе А было проведено только хирургическое лечение, а пациентам в группе В — комплексное лечение (хирургическое лечение + адъювантная химиотерапия). Все пациенты были под наблюдением в течение 60 мес. и, в зависимости от выявления отдаленных метастазов, были разделены на подгруппы. Далее были оценены клинические характеристики пациентов (возраст, пол, локализация первичной опухоли, характер выполненной операции) и морфологические характеристики опухоли (определение уровня экспрессии Ki-67; наличие и уровня экспрессии хемокинового рецептора CCRX4 и молекулярно-генетический анализ (определение мутации в 12,13 кодонах гена KRAS).
Результаты. Выявлены дополнительные факторы прогноза, влияющие на показатель безрецидивной выживаемости: экспрессия хемокинового рецептора CXCR4, индекс пролиферации Ki-67 и локализация опухоли.
Заключение. Дополнительные факторы прогноза, определенные в результате работы, целесообразно использовать для оптимизации комплексного лечения у пациентов с РОК.
The Role of Correcting Nutritional Deficiencies in Increasing the Effectiveness of Treatment in Patients with Locally Advanced Gastric Cancer
Authors: Бриш Надежда Александровна , Семиглазова Татьяна Юрьевна , Карачун Алексей Михайлович , Ткаченко Елена Викторовна , Телетаева Гульфия Мидхатовна , Страх Любовь Владимировна , Служев Максим Иванович , Алексеева Юлия Владимировна , Кондратьев Сергей Валерьевич , Лебедев Константин Константинович , Понасенко Ольга Игоревна , Филатова Лариса Валентиновна , Каспаров Борис Сергеевич , Семиглазов Владислав Владимирович , Беляев Алексей Михайлович 
Published: December 2024

Введение. Известно, что наличие признаков нутритивной недостаточности у пациентов с местнораспространенным раком желудка влечет за собой увеличение частоты осложнений противоопухолевого лечения, ухудшение качества жизни и сокращение ее продолжительности. В связи с этим актуальной является оценка влияния коррекции нутритивной недостаточности на эффективность комплексного лечения пациентов с местнораспространенным раком желудка.
Цель. Оценка прогностической роли коррекции нутритивных нарушений у пациентов с местнораспространенным раком желудка, подлежащих комплексному противоопухолевому лечению.
Материалы и методы. В ходе исследования проанализированы данные 200 пациентов с верифицированным местнораспространенным раком желудка. В группе наблюдения в ходе проспективной части исследования 100 пациентам на фоне противоопухолевого лечения проводилась нутритивная поддержка. В группу исторического контроля были включены ретроспективные данные о 100 пациентах, получавших противоопухолевое лечение без нутритивной поддержки. Оценивалась 5-летняя бессобытийная и общая выживаемость пациентов с местнораспространенным раком желудка, отдельно проанализированы показатели выживаемости в зависимости от исходного нутритивного статуса.
Результаты. 5-летняя бессобытийная выживаемость у пациентов без нутритивной недостаточности в группе наблюдения составила 86,7 % против 52,3 % в группе исторического контроля (р < 0,001); у пациентов с нутритивной недостаточностью — 48,9 % против 46,6 % соответственно (р = 0,24). Пятилетняя общая выживаемость пациентов без нутритивной недостаточности в группе наблюдения составила 92,7 % против 83,5 % в группе исторического контроля (р < 0,23); у пациентов с нутритивной недостаточностью — 72,7 % против 70,2 % соответственно (р < 0,752). Пациенты в группе наблюдения, не имевшие исходных признаков нутритивной недостаточности, показали лучшие показатели общей выживаемости, в отличие от остальных подгрупп (92,7 %).
Заключение. Наличие исходных признаков нутритивной недостаточности негативно отражается на отдаленных результатах комплексного лечения пациентов с местнораспространенным раком желудка. Профилактическое назначение нутритивной поддержки пациентам, не имеющим исходных нутриционных нарушений, опосредованно позволяет достичь наилучших результатов бессобытийной и общей выживаемости.
Influence of Preoperative Hepatic Artery Chemoembolization on Long-Term Oncological Outcomes after Liver Resection for Hepatocellular Carcinoma and Assessment of Predictors of Recurrence
Authors: Жуйков Владимир Николаевич , Гранов Дмитрий Анатольевич , Поликарпов Алексей Александрович , Тилеубергенов Инхат Ибрагимович , Руткин Игорь Олегович , Шералиев Аслан Рахимджонович 
Published: December 2024

Цель. Оценить роль предоперационной химиоэмболизации печеночной артерии и выявить предикторы развития рецидива гепатоцеллюлярной карциномы после радикальных резекций.
Материалы и методы. С 2011 по 2022 гг. выполнено 80 резекций печени по поводу гепатоцеллюлярной карциномы на фоне цирроза печени А. Чайлд-Пью. У 36 пациентов хирургическому вмешательству предшествовала химиоэмболизация печеночной артерии от одного до 4 циклов с последующей оценкой ответа по m-RECIST и динамики альфа-фетопротеина. У 44 пациентов резекция выполнена без неоадъювантного лечения. У всех пациентов оценивалась степень дифференцировки опухоли.
Результаты. Частота пострезекционной печеночной недостаточности и послеоперационных осложнений в двух группах достоверно не различалась (p > 0,05). В обеих группах при низкодифференцированной опухоли рецидив возник в 100 % случаев, умеренно дифференцированной — в 84 %, высоко дифференцированной — в 50 % (p < 0,05). В основной группе рост АФП приводил к рецидиву в 100 % случаев, у пациентов со снижением онкомаркера — в 59 % (p < 0,05). В основной группе при полном ответе по mRECIST рецидива не отмечено, при частичном ответе — рецидив в 45 % случаев, при стабилизации заболевания — 82 %, при прогрессировании — в 100 % (p < 0,05). Медианы безрецидивной и общей выживаемости в группах с предоперационным лечением и без него составили 10 и 15,5 месяцев, 72 и 48 месяцев соответственно.
Выводы. Предоперационная химиоэмболизация при гепатоцеллюлярной карциноме безопасна, увеличивает медиану общей выживаемости после резекции. Рост АФП, отсутствие полного или частичного ответа по mRECIST в группе с предоперационным лечением и низкая степень дифференцировки в обеих группах являются предикторами рецидива после радикальных резекций печени.
Brick masonry reinforcement with methyl methacrylate injection
Authors: Ishchuk E. M. , Ishchuk M. K. 
Published: December 2024

Introduction. Structural reinforcement of brick and stone masonry by grouting materials under pressure is an efficient approach to restoring the masonry integrity, and, in some cases, improving its bearing capacity. This paper presents the results of research studies into the strength of a masonry structure reinforced by methyl methacrylate injection. This research is part of a larger project, which was launched in 2004 and continues to date. Due to the high penetrating ability of methyl methacrylate, reinforcement of masonry structures with small crack opening seems highly promising.Aim. Evaluation of the effectiveness of methyl methacrylate injection for masonry reinforcement.Materials and methods. The experimental studies were carried out in two stages. At the first stage, masonry specimens manufactured in the form of columns were subjected to compression tests. At the second stage, methyl methacrylate was injected under pressure into the specimens with formed cracks. The as-reinforced specimens were tested again in order to evaluate their strength increase factor.Results. The distribution of methyl methacrylate throughout masonry when injected under pressure, as well as through individual brick and mortar specimens without pressure, was studied. It is shown that the technology of masonry reinforcement by methyl methacrylate differs significantly from that of concrete consolidaton, where higher pressures contribute to its more even distribution over the concrete body.Conclusions. Injection of methyl methacrylate into masonry with multiple load cracks can increase its loadbearing capacity by at least 1.2 times.The results of research were used in the development of normative documents on reinforcement of masonry structures.
Rapid source forgetting across modalities: A problem for working memory models
Authors: Delooze Molly A. , Guitard Dominic , Cowan Nelson , Morey Candice C. 
Published: December 2024

AbstractWorking memory is a cognitive system that enables the temporary retention (usually a few seconds) of a limited amount of information. However, recent evidence has posed challenges to the conventional understanding of working memory's persistence. Chen et al. (Psychological Science, 29(4), 645–655, 2018) demonstrated that participants can easily make judgments using a stimulus’s identity but cannot recall from which source the information came (presented either as a written word or a color patch) just milliseconds earlier. This “Source Amnesia” carries substantial implications for working memory models but has yet to be explored within the realm of verbal information. We fill this gap by investigating the robustness and generalizability of this rapid forgetting phenomenon. We first replicate the observed effect within the visual domain (Experiment 1) and subsequently extend it to the verbal domain (Experiment 2). Finally, we test the idea that participants may instead encode a positional context (Experiment 3), in line with the Interference model (Oberauer & Lin, Psychological Review, 124(1), 21, 2017). Aligning with the work of Chen et al. (Psychological Science, 29(4), 645–655, 2018), our results consistently reveal a pronounced tendency for rapid forgetting, for both visual and verbal information regardless of whether the information is elicited for recall by format or position cues. The theoretical implications of these findings for current memory models are discussed.
The effect of instructed refreshing on working memory: Is the memory boost a function of refreshing frequency or refreshing duration?
Authors: Vergauwe Evie , Souza Alessandra S. , Langerock Naomi , Oberauer Klaus 
Published: December 2024

AbstractRefreshing is assumed to reactivate the contents of working memory in an attention-based way, resulting in a boost of the attended representations and hence improving their subsequent memory. Here, we examined whether the refreshing-induced memory boost is a constant or a gradual, time-dependent phenomenon. If the beneficial effect of refreshing on memory performance is due to the information being selected for refreshing (i.e., selection hypothesis), a constant memory boost is expected to occur each time an item is selected for refreshing, with better memory performance for items that are selected more often. If, however, the beneficial effect of refreshing on memory performance is due to spending time in the focus of attention during refreshing (i.e., duration hypothesis), a gradual memory boost is expected, with the size of the memory boost being a direct function of how long the item has been the object of focused attention. To distinguish between these hypotheses, we instructed and guided the use of refreshing during retention through the presentation of cues, and varied the number of refreshing steps and their duration independently. The number of refreshing steps, but not their duration, had an effect on recall, in agreement with the selection hypothesis. However, some of the results were less robust than anticipated, indicating that the effect of instructed refreshing is limited to certain task parameters.
Spontaneous associative thought may facilitate scene-gist memory via implicit scene-labeling
Authors: Baror Shira , Aminoff Elissa , Kenett Yoed N. 
Published: December 2024

AbstractSpontaneous associative processes (e.g., mind wandering, spontaneous memory recollection) are prevalent in everyday life, yet their influence on perceptual scene memory is under debate. Given that scene perception involves extraction of contextual associations, we hypothesized that associative thought would enhance scene memory by promoting encoding of contextual associations. In an online experiment (N = 75), participants viewed scenes, and following each scene either generated chained-free associations (associative processing), or, as control, listed words that begin with a specific letter (phonological processing). Scene memory was tested after an intermediate creativity task, which is also shown to rely on associative processes. Results revealed that associative thought, regardless of its conceptual (semantic) distances between responses, enhanced scene-gist memory, but hampered memory of scene details, implying that associative thought facilitates contextual encoding. In a follow-up experiment (N = 74), we found that the effect of associative thought on scene-gist memory was mediated by scene labeling. When participants were asked to explicitly label the scene before completing an associative processing or a phonological processing task, scene-gist memory was prioritized at the expense of scene details, eliminating the memory differences between tasks. These findings imply that labeling past perceived scenes, whether explicitly or implicitly during associative thought, facilitates scene-gist memory. Lastly, in both experiments, creativity was not correlated with scene memory but was positively correlated with the semantic distances between scene-based associations, extending past findings that link creativity with the breadth of associative processes. Together, these findings highlight the likely effect of post-perceptual associative processes on higher-order cognitive functions, such as memory consolidation and creative thought.
Perspektif Pemasaran Media Sosial Tiktok Terhadap Minat Beli Produk Kosmetik
Authors: Sutrisno Niantoro , Azriani Fitriyah , Husein Tuasikal Husein 
Published: December 2024

Today's modern world cannot be separated from various digital platforms used in the company’s marketing. One social media platform that is experiencing rapid growth in users is Tiktok, a digital platform that allows users to share videos. Currently, the Tiktok social media platform is used by 112 million Indonesians or second in the world after 116 million users in the United States (data from the website data.goodstats.id). However, in Indonesia the use of the Tiktok social media platform has not been optimally used as part of the company's product marketing strategy. Based on these conditions, this research was conducted with the aim of examining and identifying the influence of Tiktok Social Media on Interest in Buying Cosmetic Products. The method used in this research is a quantitative method with a survey approach. Meanwhile, data collection was carried out by distributing questionnaires to 100 students from 3 universities in Bekasi Regency. The results of the analysis of the processed data show that Tiktok Social Media Marketing has an influence on Interest in Buying Cosmetic Products.
New Candidates for Organic-rich Regions on Ceres
Authors: Rizos J. L. , Sunshine J. M. , Daly R. T. , Nathues A. , De Sanctis C. , Raponi A. , Pasckert J. H. , Farnham T. L. , Kloos J. , Ortiz J. L. 
Published: December 2024

Abstract
We explore the spatial distribution of organics on Ceres using the visible and near-infrared data collected by the Dawn mission. We employ a spectral mixture analysis (SMA) approach to map organic materials within the Ernutet crater at the highest available spatial resolution, thereby revealing a discontinuous, granular distribution and a possible association with an ancient crater on which Ernutet has been superimposed. The SMA technique also helps us identify 11 new areas as potential sites for organics. These regions are predominantly located within craters or along their walls, resembling the distribution pattern observed in Ernutet, which implies a possible geological link with materials exposed from beneath the surface. In one of these candidate regions situated in the Yalode quadrangle, we detected the characteristic 3.4 μm absorption band in the infrared spectrum, indicative of organics and carbonates. By combining the spatial resolution of the Framing Camera data with the spectral resolution of the Visual and Infrared Imaging Spectrometer using SMA, we investigated the distribution of the 3.4 μm band in this quadrangle. The absorption pattern correlates with the Yalode/Urvara smooth material unit, which formed after significant impacts on Ceres. The association of organic-rich materials with complex and multiple large-impact events supports an endogenous origin for the organics on Ceres.
Regional Variation in Carpal Tunnel Release Utilization, Reimbursement, Practice Styles, and Patient Populations: A Temporal Analysis
Authors: Gill Vikram S. , Holle Alejandro M. , Lin Eugenia , Tummala Sailesh V. , Haglin Jack M. , Renfree Kevin J. 
Published: December 2024

Background
The purpose of this study was to evaluate changes in open carpal tunnel release (OCTR) and endoscopic carpal tunnel release (ECTR) utilization, reimbursement, and patient demographics in the Medicare population from 2013 to 2021 at national and regional levels.

Materials and Methods
The Medicare Physician & Other Practitioners database from 2013 to 2021 was queried to extract all instances of OCTR and ECTR. Utilization per 10,000 beneficiaries, inflation-adjusted reimbursement, and patient characteristics were extracted for OCTR and ECTR each year. Data were stratified by region based on US Census guidelines. Kruskal-Wallis tests and multivariable linear regressions were performed.

Results
From 2013 to 2021, national utilization per 10,000 beneficiaries increased by 6% for OCTR and by 50% for ECTR. In 2021, the Midwest had the greatest utilization of OCTR (29 of 10,000) and the lowest utilization of ECTR (7 of 10,000). Inflation-adjusted reimbursement declined for both OCTR and ECTR during the study period (10.3% and 11.8%, respectively), with the South having the lowest reimbursement for both procedures. The severity of patient comorbidity profiles and dual Medicare-Medicaid enrollees decreased for both procedures as well.

Conclusion

Both OCTR and ECTR utilization have increased, while inflation-adjusted reimbursement has decreased. Patient populations encompassed fewer dual Medicare-Medicaid enrollees, indicating surgeons may be more selective in operative indications. These findings should be addressed to ensure the economic sustainability of carpal tunnel release procedures and equitable access to quality hand care for all patients with Medicare. [
Orthopedics
. 2025;48(1):e45–e51.]
Differences in Volume, Reimbursement, Practice Styles, and Patient Characteristics Between Male and Female Surgeons for Open and Endoscopic Carpal Tunnel Release
Authors: Holle Alejandro M. , Gill Vikram S. , Lin Eugenia , Cancio-Bello Alexandra M. , Iturregui Jose M. , Haglin Jack M. , Renfree Kevin J. 
Published: December 2024

Background
The goal of this study was to evaluate differences in carpal tunnel release volume, reimbursement, practice styles, and patient populations between male and female surgeons from 2013 to 2021.

Materials and Methods

The Medicare Physician & Other Practitioners database was queried from 2013 to 2021. Procedure volume, reimbursement, surgeon information, and patient demographic characteristics were collected for any surgeon who performed at least 10 open carpal tunnel release (OCTR) or endoscopic carpal tunnel release (ECTR) procedures that year. The Welch
t
test, the Kruskal-Wallis test, and multivariable linear regressions were conducted to compare male and female surgeons and analyze geographic and annual differences.

Results

From 2013 to 2021, the proportion of carpal tunnel releases performed by female surgeons increased for OCTR by 4.5% (7.1% to 11.6%) and for ECTR by 3.3% (4.8% to 8.1%). Female OCTR surgeons on average had fewer beneficiaries per surgeon (443.37 vs 354.20,
P
<.001), performed fewer billable services per beneficiary (6.37 vs 5.35,
P
=.03), and performed fewer unique billable services (91.13 vs 77.79,
P
<.001) compared with male surgeons. Female OCTR surgeons also saw a lower percentage of White patients (88.14 vs 86.48,
P
=.003) and a higher percentage of female patients (60.06 vs 61.70,
P
<.001) and dual-enrolled Medicare-Medicaid patients (10.54 vs 11.22,
P
=.046).

Conclusion

Female representation among OCTR and ECTR surgeons increased across the country. Male OCTR surgeons billed for more services and performed more services per beneficiary and also treated a higher proportion of White patients and dual Medicare-Medicaid enrollees compared with female surgeons. Future studies are required to identify reasons for and ways to address these disparities. [
Orthopedics
. 2025;48(1):57–63.]
Caging Four-Toed Salamander Nests Reduces Nest Predation in Northeastern Tennessee
Authors: Ferguson Kalin J. , Hamed M. Kevin 
Published: December 2024

Abstract
Four-toed salamanders Hemidactylium scutatum have disjunct populations in the United States and Canada. Increased predation could threaten their populations and cause them to become limited in certain areas. Installing cages to protect threatened populations can reduce the chance of predation. To test the efficacy of cages, we examined the effects of caging four-toed salamander nests in northeastern Tennessee. We randomly selected 65/120 nests to cage from our study sites at the South Holston Weir Dam and Bouton Tract in Sullivan County, Tennessee. Based on photos from a camera trapping survey, we found that raccoons Procyon lotor were the main predators of uncaged four-toed salamander nests. Raccoon damage resulted in portions of moss being ripped away and the disappearance of eggs. Twenty-six percent of uncaged nests were preyed upon, whereas none of the caged nests were preyed upon. Our findings provide a strategy for improving nest success of four-toed salamanders and could be used to protect threatened populations.