bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in US Outpatient Antibiotic Prescriptions From 2011–2016
Authors: King Laura M , Bartoces Monina , Fleming-Dutra Katherine E , Roberts Rebecca M , Hicks Lauri A 
Published: March 2019

Abstract

Background
While antibiotics are life-saving drugs, their use is not without risk, including adverse events and antibiotic resistance. The majority of US antibiotic prescriptions are prescribed in outpatient settings, making outpatient antibiotic prescribing an important antibiotic stewardship target. The primary objective of this study was to describe trends in US outpatient oral antibiotic prescriptions from 2011–2016.

Methods
We estimated annual oral antibiotic prescription rates using national prescription dispensing count data from IQVIA Xponent, divided by census estimates for 2011–2016. We calculated the ratio of broad- to narrow-spectrum prescriptions by dividing broad-spectrum prescription rates by narrow-spectrum prescription rates. We used Poisson models to estimate prevalence rate ratios, comparing 2011 and 2016 antibiotic prescription rates, and linear models to evaluate temporal trends throughout the study period.

Results
Oral antibiotic prescription rates decreased 5%, from 877 prescriptions per 1000 persons in 2011 to 836 per 1000 persons in 2016. During this period, rates of prescriptions dispensed to children decreased 13%, while adult rates increased 2%. The ratio of broad- to narrow-spectrum antibiotics decreased from 1.62 in 2011 to 1.49 in 2016, driven by decreases in macrolides and fluoroquinolones. The proportion of prescriptions written by nurse practitioners and physician assistants increased during the study period; in 2016, these providers prescribed over one-quarter of all antibiotic prescriptions.

Conclusions
Outpatient antibiotic prescription rates, especially of broad-spectrum agents, have decreased in recent years. Clinicians who prescribe to adults, including nurse practitioners and physician assistants, are important targets for antibiotic stewardship.
Modality and Interrelations Among Language, Reading, Spoken Phonological Awareness, and Fingerspelling
Authors: Lederberg Amy R , Branum-Martin Lee , Webb Mi-young , Schick Brenda , Antia Shirin , Easterbrooks Susan R , Connor Carol McDonald 
Published: March 2019

Abstract
Better understanding of the mechanisms underlying early reading skills can lead to improved interventions. Hence, the purpose of this study was to examine multivariate associations among reading, language, spoken phonological awareness, and fingerspelling abilities for three groups of deaf and hard-of-hearing (DHH) beginning readers: those who were acquiring only spoken English (n = 101), those who were visual learners and acquiring sign (n = 131), and those who were acquiring both (n = 104). Children were enrolled in kindergarten, first, or second grade. Within-group and between-group confirmatory factor analysis showed that there were both similarities and differences in the abilities that underlie reading in these three groups. For all groups, reading abilities related to both language and the ability to manipulate the sublexical features of words. However, the groups differed on whether these constructs were based on visual or spoken language. Our results suggest that there are alternative means to learning to read. Whereas all DHH children learning to read rely on the same fundamental abilities of language and phonological processing, the modality, levels, and relations among these abilities differ.
The Importance of Being Revolutionary: Oath-taking and the ‘Feeling Rules’ of Violence (1789–1794)
Authors: Buscemi Francesco 
Published: March 2019

Abstract
Historians of the French Revolution have identified many cultural and ideological sources of its violence: ideological commitments to virtue, the inevitable clashes involved in founding a new order, the emotions of fear and anger unleashed by political upheaval, and religious commitments to Catholicism. Rarely, however, have they explored how civic religious practices gave rise to violence. This article shows how the practice of oath-taking generated emotional “sacred” commitments and a propensity for violence in maintaining them. Given the legal and institutional weaknesses of the new regime, oath-taking helped establish political allegiances, but oaths often came into conflict with other sacred commitments, old and new. The widespread practice of oath-taking during the Revolution offers a revealing vantage point to understand the sacred, civic-religious dimensions of these various political commitments. The imperative to maintain vows, I argue, prompted contemporaries to see violence as extreme but necessary.
Confocal Laser Endomicroscopy in the Evaluation of Inflammatory Bowel Disease
Authors: Buchner Anna M 
Published: March 2019

Abstract
Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, can be effectively monitored with the use of endoscopy. The additional application of small field imaging technology such as confocal laser endomicroscopy CLE during ongoing endoscopic evaluation has led to real-time visualization of mucosal abnormalities and thus in vivo histology. The endomicroscopy (CLE) can improve IBD endoscopic evaluation by identifying seemingly normal-appearing mucosa, assessing the function of the intestinal barrier of the epithelium and vascular permeability, and by characterizing any mucosal lesions, including dysplastic lesions. CLE used during conventional endoscopy could especially facilitate the evaluation of mucosal healing in IBD. In addition, future developments in molecular imaging in IBD may optimize therapeutic approaches by identifying mucosal targets for therapy and determining the reasons for lack of response to specific therapy or subsequent loss of the response.
Contraception, Venous Thromboembolism, and Inflammatory Bowel Disease: What Clinicians (and Patients) Should Know
Authors: Limdi Jimmy K , Farraye Jennifer , Cannon Rachel , Woodhams Elisabeth , Farraye Francis A 
Published: March 2019

AbstractThe peak incidence of the inflammatory bowel diseases (IBDs) is between the second and fourth decades of life, which coincides with prime reproductive years. Unplanned or mistimed pregnancies may account for nearly half of all pregnancies and are associated with adverse consequences such as a higher risk of delayed preconceptual care, increased risk of preterm birth, low birth weight, and adverse maternal and neonatal outcomes. Increased IBD activity during pregnancy is also associated with adverse pregnancy-related outcomes, such as miscarriage, intrauterine growth retardation, and preterm birth. Furthermore, the increased risk of venous thromboembolism (VTE) conferred by active IBD may be potentially augmented by hormonal contraceptives. Recent literature suggests that women with IBD seek counseling on contraception from gastroenterologists in preference to their primary care physicians. Meanwhile, attitudes and awareness regarding contraception counseling remain suboptimal, underpinning the importance and need for physician and patient education in this area. We discuss the association between contraception and IBD, benefits and risks associated with various contraceptive methods in women with IBD, and practical recommendations for clinicians caring for women with IBD.10.1093/ibd/izz025_video1 izz025.video1 6014727518001 10.1093/ibd/izz025_video2 izz025.video2 6014726992001
How Does Crossing Roads with Friends Impact Risk Taking in Young Adolescents and Adults?
Authors: O’Neal Elizabeth E , Jiang Yuanyuan , Brown Kathryne , Kearney Joseph K , Plumert Jodie M 
Published: March 2019

AbstractObjectiveThe goal of this investigation was to examine how crossing roads with a friend versus alone affects gap decisions and movement timing in young adolescents and adults.MethodsNinety-six 12-year-olds and adults physically crossed a single lane of continuous traffic in an immersive pedestrian simulator. Participants completed 30 crossings either with a friend or alone. Participants were instructed to cross the road without being hit by a car, but friend pairs were not instructed to cross together.ResultsPairs of adolescent friends exhibited riskier road-crossing behavior than pairs of adult friends. For gaps crossed together, adult pairs were more discriminating in their gap choices than adult solo crossers, crossing fewer of the smaller gaps and more of the larger gaps. This pattern did not hold for 12-year-old pairs compared to 12-year-old solo crossers. To compensate for their less discriminating gap choices, pairs of 12-year-olds adjusted their movement timing by entering and crossing the road more quickly. For gaps crossed separately, both adult and 12-year-old first crossers chose smaller gaps than second crossers. Unlike adults, 12-year-old first crossers were significantly less discriminating in their gap choices than 12-year-old second crossers.ConclusionsCompared to adults, young adolescents took riskier gaps in traffic when crossing virtual roads with a friend than when crossing alone. Given that young adolescents often cross roads together in everyday life, peer influences may pose a significant risk to road safety in early adolescence.
The role of the augmin complex in establishing microtubule arrays
Authors: Tian Juan , Kong Zhaosheng 
Published: March 2019

AbstractMicrotubule-dependent microtubule nucleation occurs on the lateral surface of pre-existing microtubules and provides a highly efficient means of amplifying their populations and reorganizing their architectures. The γ‑tubulin ring complex serves as the template to initiate nascent microtubule polymerization. Augmin, a hetero-octameric protein complex, acts as a recruiting factor to target the γ‑tubulin ring complex to pre-existing microtubules and trigger new microtubule growth. Although microtubule-dependent microtubule nucleation has been extensively studied in both animal and plant cells, it remains unclear how the augmin complex assembles in plant cells, especially in cell-cycle-specific and cell-type-specific manners, and how its spatial structure orchestrates the nucleation geometry. In this review, we summarize the advances in knowledge of augmin-dependent microtubule nucleation and the regulation of its geometry, and highlight recent findings and emerging questions concerning the role of the augmin complex in establishing microtubule arrays and the cell-cycle-specific composition of augmin in plant cells.
Successful Surgical Treatment of Severe Perforating Diametric Craniocerebral Gunshot Wound Sustained during Combat: A Case Report
Authors: Sirko Andrii , Kyrpa Igor , Yovenko Ihor , Miziakina Kateryna , Romanukha Dmytro 
Published: March 2019

AbstractMany researchers classify perforating diametric craniocerebral gunshot wounds as fatal because mortality exceeds 96% and the majority of patients with such injuries die before hospitalization. A 23-year-old Ukrainian male soldier was admitted to a regional hospital with a severe perforating craniocerebral wound in a comatose state (Glasgow Coma Scale score, 5). Following brain helical computed tomography, the patient underwent primary treatment of the cerebral wound with primary duraplasty and inflow/outflow drainage. After 18 days of treatment in the intensive care unit, he was transferred to a military hospital for further rehabilitation. This report details our unusual case of successful treatment of a perforating diametric craniocerebral gunshot wound.
Comparison of National and Local Approaches to Detecting Suicides in Healthcare Settings
Authors: Riblet Natalie B , Shiner Brian , Watts Bradley V , Britton Peter 
Published: March 2019

AbstractIntroductionIn order to address the problem of suicide, healthcare providers and researchers must be able to accurately identify suicide deaths. Common approaches to detecting suicide in the healthcare setting include the National Death Index (NDI) and Root-Cause Analysis (RCA) methodology. No study has directly compared these two methods.Materials and MethodsSuicide reporting was evaluated within the Veterans Affairs (VA) healthcare system. All suicides were included that occurred within 7 days of discharge from an inpatient mental health unit and were reported to the VA through the NDI record linkage and/or RCA database between 2002 and 2014. The proportion of suicide deaths that were identified by NDI and found in the RCA database were calculated. Potential misclassification by the NDI was evaluated, whereby the RCA database identified a suicide case, but the NDI classified the death as a non-suicide.ResultsIn the study period, the NDI identified 222 patients who died by suicide within 7 days of discharge, while the RCA database only detected 95 reports of suicide. A comparison of cases across the two methods indicated that the RCA database identified only 35% (N = 78) of NDI detected suicides (N = 222). Conversely, the RCA database detected 13 suicide cases that the NDI had coded as deaths due to accidental poisoning or other causes. Importantly, RCA accounted for 13% (N = 7) of overdose suicides identified in all databases (N = 52).ConclusionsCombining national and local approaches to detect suicide may help to improve the classification of suicide deaths in the healthcare setting.
Extended Ketogenic Diet and Physical Training Intervention in Military Personnel
Authors: LaFountain Richard A , Miller Vincent J , Barnhart Emily C , Hyde Parker N , Crabtree Christopher D , McSwiney Fionn T , Beeler Mathew K , Buga Alex , Sapper Teryn N , Short Jay A , Bowling Madison L , Kraemer William J , Simonetti Orlando P , Maresh Carl M , Volek Jeff S 
Published: March 2019

AbstractIntroductionKetogenic diets (KDs) that elevate ketones into a range referred to as nutritional ketosis represent a possible nutrition approach to address the emerging physical readiness and obesity challenge in the military. An emerging body of evidence demonstrates broad-spectrum health benefits attributed to being in nutritional ketosis, but no studies have specifically explored the use of a KD in a military population using daily ketone monitoring to personalize the diet prescription.Materials and MethodsTo evaluate the feasibility, metabolic, and performance responses of an extended duration KD, healthy adults (n = 29) from various military branches participated in a supervised 12-wk exercise training program. Fifteen participants self-selected to an ad libitum KD guided by daily measures of capillary blood ketones and 14 continued their normal mixed diet (MD). A battery of tests were performed before and after the intervention to assess changes in body mass, body composition, visceral fat, liver fat, insulin sensitivity, resting energy metabolism, and physical performance.ResultsAll KD subjects were in nutritional ketosis during the intervention as assessed by daily capillary beta-hydroxybutyrate (βHB) (mean βHB 1.2 mM reported 97% of all days) and showed higher rates of fat oxidation indicative of keto-adaptation. Despite no instruction regarding caloric intake, the KD group lost 7.7 kg body mass (range −3.5 to −13.6 kg), 5.1% whole-body percent fat (range −0.5 to −9.6%), 43.7% visceral fat (range 3.0 to −66.3%) (all p &lt; 0.001), and had a 48% improvement in insulin sensitivity; there were no changes in the MD group. Adaptations in aerobic capacity, maximal strength, power, and military-specific obstacle course were similar between groups (p &gt; 0.05).ConclusionsUS military personnel demonstrated high adherence to a KD and showed remarkable weight loss and improvements in body composition, including loss of visceral fat, without compromising physical performance adaptations to exercise training. Implementation of a KD represents a credible strategy to enhance overall health and readiness of military service members who could benefit from weight loss and improved body composition.
Agriculture: science and technology safeguard sustainability
Authors: Jia Hepeng 
Published: March 2019

Abstract
China has traditionally placed tremendous importance on agricultural research. Meanwhile, in recent years, sustainable agriculture has been increasingly highlighted in both policy agenda and the capital market. However, while terms like environmental friendliness, low carbon, organic and green agriculture have become buzzwords in the media, few meaningful discussions have been raised to examine the relationship between science and technology (S&T) development and sustainable agriculture. What's more, some environmentalists stress that sustainable agriculture should abandon modern agriculture's heavy reliance on science and industrialization, making the link between agricultural S&T and sustainable agriculture seem problematic. What is the truth? If S&T are to play an important role in advancing sustainable agriculture, what is the current status of the field? What factors have caused the sustainable development of agriculture in China? At an online forum organized by the National Science Review (NSR), Hepeng Jia, commissioned by NSR executive editor-in-chief Mu-ming Poo, asked four scientists in the field to examine the dynamic relationship between sustainable agriculture and agricultural S&T in the Chinese context.

Jikun Huang
Agricultural economist at Peking University, Beijing, China

Xiaofeng Luo
Agricultural economist at Huazhong Agricultural University, Wuhan, China

Jianzhong Yan
Agricultural and environmental scientist at Southwest University, Chongqing, China

Yulong Yin
Veterinary scientist at Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China

Hepeng Jia (Chair)
Science communication scholar at Cornell University, Ithaca, NY, USA
Twenty-Year Trends in Antimicrobial Susceptibilities Among Staphylococcus aureus From the SENTRY Antimicrobial Surveillance Program
Authors: Diekema Daniel J , Pfaller Michael A , Shortridge Dee , Zervos Marcus , Jones Ronald N 
Published: March 2019

AbstractBackgroundStaphylococcus aureus is among the most common human pathogens, with therapy complicated by the epidemic spread of methicillin-resistant Staphylococcus aureus (MRSA).MethodsThe SENTRY Antimicrobial Surveillance Program evaluated the in vitro activity of &gt;20 antimicrobials against 191 460 clinical S. aureus isolates collected from 427 centers in 45 countries from 1997 to 2016. Each center contributed isolates and clinical data for consecutive episodes of bacteremia, pneumonia in hospitalized patients, urinary tract infection, and skin and skin structure infection.ResultsOverall, 191 460 S. aureus isolates were collected, of which 77 146 (40.3%) were MRSA, varying geographically from 26.8% MRSA in Europe to 47.0% in North America. The highest percentage of MRSA was in nosocomial isolates from patients aged &gt;80 years. Overall, MRSA occurrences increased from 33.1% in 1997–2000 to a high of 44.2% in 2005–2008, then declined to 42.3% and 39.0% in 2009–2012 and 2013–2016, respectively. S. aureus bacteremia had a similar trend, with nosocomial and community-onset MRSA rates peaking in 2005–2008 and then declining. Vancomycin activity against S. aureus remained stable (minimum inhibitory concentration [MIC]90 of 1 mg/L and 100% susceptibility in 2016; no increase over time in isolates with a vancomycin MIC &gt;1 mg/L). Several agents introduced during the surveillance period exhibited in vitro potency against MRSA.ConclusionsIn a large global surveillance program, the rise of MRSA as a proportion of all S. aureus peaked a decade ago and has declined since, consistent with some regional surveillance program reports. Vancomycin maintained high activity against S. aureus, and several newer agents exhibited excellent in vitro potencies.
Antimicrobial Resistance Surveillance and New Drug Development
Authors: Sader Helio S , Rhomberg Paul R , Fuhrmeister Andrew S , Mendes Rodrigo E , Flamm Robert K , Jones Ronald N 
Published: March 2019

Abstract
Surveillance represents an important informational tool for planning actions to monitor emerging antimicrobial resistance. Antimicrobial resistance surveillance (ARS) programs may have many different designs and can be grouped in 2 major categories based on their main objectives: (1) public health ARS programs and (2) industry-sponsored/product-oriented ARS programs. In general, public health ARS programs predominantly focus on health care and infection control, whereas industry ARS programs focus on an investigational or recently approved molecule(s). We reviewed the main characteristics of industry ARS programs and how these programs contribute to new drug development. Industry ARS programs are generally performed to comply with requirements from regulatory agencies responsible for commercial approval of antimicrobial agents, such as the US Food and Drug Administration, European Medicines Agency, and others. In contrast to public health ARS programs, which typically collect health care and diverse clinical data, industry ARS programs frequently collect the pathogens and perform the testing in a central laboratory setting. Global ARS programs with centralized testing play an important role in new antibacterial and antifungal drug development by providing information on the emergence and dissemination of resistant organisms, clones, and resistance determinants. Organisms collected by large ARS programs are extremely valuable to evaluate the potential of new agents and to calibrate susceptibility tests once a drug is approved for clinical use. These programs also can provide early evaluations of spectrum of activity and postmarketing trends required by regulatory agencies, and the programs may help drug companies to select appropriate dosing regimens and the appropriate geographic regions in which to perform clinical trials. Furthermore, these surveillance programs provide useful information on the potency and spectrum of new antimicrobial agents against indications and organisms in which clinicians have little or no experience. In summary, large ARS programs, such as the SENTRY Antimicrobial Surveillance Program, contribute key data for new drug development.