bluuebunny/crossref_metadata_2025_split huggingface dataset:
FeS2−AuNPs Nanocomposite as Mimicking Enzyme for Constructing Signal‐off Sandwich‐type Electrochemical Immunosensor Based on Electroactive Nickel Hexacyanoferrate as Matrix
Authors: Zhang Lina , Xie Xiyue , Yuan Yali , Chai Yaqin , Yuan Ruo 
Published: February 2019

AbstractIn this work, a novel sandwich‐type electrochemical immunosensor with electroactive nickel hexacyanoferrate nanoparticles (NiHCFNPs) as matrix was constructed for α‐fetoprotein (AFP) detection in a signal‐off manner by using FeS2−AuNPs nanocomposite catalyzed insoluble precipitation to significantly inhibit the electrochemical signal. Initially, the NiHCFNPs with excellent electrochemical property was modified on the electrodeposited nano‐Au electrode to obtain a strong initial electrochemical signal. Subsequently, another nano‐Au layer was formed for immobilization of capture antibody (Ab1). In the presence of target AFP, the prepared FeS2−AuNPs‐Ab2 bioconjugate could be specifically recognized and immobilized on electrode through the sandwich‐type immunoreaction. The FeS2 with large specific surface areas were used as scaffolds to load abundant mimicking enzyme AuNPs. With the help of hydrogen peroxide (H2O2), FeS2−AuNPs with peroxidase‐like activity accelerated the 4‐chloro‐1‐naphthol (4‐CN) oxidation with generation of insoluble precipitation on electrode, which would greatly hinder the electron transfer and thus caused the decrease of electrochemical signal for quantitative determination of AFP. This approach achieved a wide dynamic linear range from 0.0001 to 100 ng mL−1 with an ultralow limit detection of 0.028 pg mL−1. Especially, the proposed AFP immunosensor can be applied to detect human serum samples with satisfactory results, indicating a potential application in clinical monitoring of tumor biomarkers.
Cu2S‐Cu3P Nanowire Arrays Self‐Supported on Copper Foam as Boosting Electrocatalysts for Hydrogen Evolution
Authors: Xu Fei , Lu Jiajia , Luo Lin , Yu Chen , Tang Zheng , Abbo Hanna S. , Titinchi Salam J. J. , Zhu Jinliang , Kang Shen Pei , Yin Shibin 
Published: February 2019

With the rapid electrochemical development of hydrogen evolution, the search for low‐cost and high activity electrocatalysts for hydrogen evolution has received extensive attention. The fabrication of self‐supported Cu2S‐Cu3P nanowire (Cu2S‐Cu3P NW) arrays on a commercial copper foam by a liquid–solid reaction and subsequent phosphatation at low temperature is reported. The corresponding scanning electron microscopy (SEM) and transmission electron microscopy (TEM) results indicate that the Cu2S‐Cu3P NW arrays have a dense nanowire (NW) structure with sulfur and phosphorous uniformly distributed on the surface of the nanowires. Interestingly, the Cu2S‐Cu3P NW arrays act as a hydrogen‐evolving cathode that when operated in 1.0 m KOH electrolyte only require a low overpotential of 158 mV to achieve a current density of 10 mA cm−2 and show a small Tafel slope of 45 mV dec−1. The activity decrease is negligible after holding at −500 mA cm–2 for 75 h, which thus demonstrates excellent stability. This could be due to the structure of nanowire arrays and synergistic effects between S and P, which could increase the specific surface area, reduce the charge transfer resistance, facilitate mass diffusion and electron transfers, and increase the active sites. This work therefore provides a simple method to prepare low‐cost and self‐supported electrocatalysts with high catalytic activity for hydrogen evolution.
Controls of preferential orientation of earthquake‐ and rainfall‐triggered landslides in Taiwan's orogenic mountain belt
Authors: Chen Yi‐Chin , Chang Kang‐Tsung , Wang Su‐Fen , Huang Jr‐Chuan , Yu Cheng‐Ku , Tu Jien‐Yi , Chu Hone‐Jay , Liu Cheng‐Chien 
Published: February 2019

AbstractLandsliding usually occurs on specific hillslope aspect, which may reflect the control of specific geo‐environmental factors, triggering factors, or their interaction. To explore this notion, this study used island‐wide landslide inventories of the Chi‐Chi earthquake in 1999 (MW = 7.6) and Typhoon Morakot in 2009 in Taiwan to investigate the preferential orientation of landslides and the controls of landslide triggers and geological settings. The results showed two patterns. The orientations of earthquake‐triggered landslides were toward the aspect facing away from the epicenter in areas with peak ground acceleration (PGA) ≥ 0.6 g and landslide ratio ≥ 1%, suggesting that the orientations were controlled by seismic wave propagation. Rainfall‐triggered landslides tended to occur on dip slopes, instead of the windward slopes, suggesting that geological settings were a more effective control of the mass wasting processes on hillslope scale than the rainfall condition. This study highlights the importance of the endogenic processes, namely seismic wave and geological settings, on the predesigned orientation of landslides triggered by either earthquake or rainfall, which can in turn improve our knowledge of landscape evolution and landslide prediction. © 2019 John Wiley & Sons, Ltd.
Why prevent when it does not pay? Prevention when health services are credence goods
Authors: Gottschalk Felix C.H. 
Published: February 2019

SummaryThis article identifies information asymmetries and the corresponding problem of overtreatment as a possible source of prevention and health disparities when patients differ with respect to their health risk. It analyzes preventive health behavior (primary prevention) and preventive health‐care utilization (secondary prevention) in markets in which patients cannot determine whether they receive excessive secondary preventive treatment—that is, where health services are credence goods. The problem of overtreatment in such markets is considered as a possible pathway through which differences in health risk lead to disparities in primary and secondary prevention as well as the corresponding health outcomes. Patients with high health risks do not invest in primary prevention, because they anticipate to be provided with unnecessary secondary prevention. Patients with lower risks invest in primary but not in secondary prevention, resulting in health losses. Furthermore, when societal groups differ with respect to their exposure to overtreatment, and we consider socioeconomic status as a possible reason, we observe disparities in primary and secondary prevention as well as the resulting health outcomes, including the “social gradient.” Several implications for empirical research are discussed.
Changes in obstetric case fatality and early newborn mortality rates in hospitals after the implementation of the Expanding Maternal and Neonatal Survival program in Indonesia: Results from a health information system
Authors: Ahmed Saifuddin , Tholandi Maya , Pedrana Alisa , Zazri Ali , Parmawaty Nony , Rahmanto Agus , Sethi Reena 
Published: February 2019

AbstractObjectivesCase fatality rates (CFRs) are often used as the key indicator for the measurement of quality of care at hospitals. We examine the trends of obstetric CFRs and very early neonatal mortality rates at hospitals in selected districts of Indonesia after implementation of a facility‐based maternal and neonatal health intervention—the Expanding Maternal and Neonatal Survival (EMAS) program.MethodsRandom‐effects Poisson regression models were fitted to routine facility data collected from 101 hospitals over approximately 4 years. Predicted incidence rates from the models were used for ascertaining the changes in CFRs and very early neonatal mortality rates during the EMAS intervention period.ResultsThe obstetric CFR from any maternal complications decreased significantly by 50% (adjusted incidence rate ratio [IRR] 0.50; 95% confidence interval [CI] 0.42–0.61) at hospitals after the implementation of the EMAS program. On average, the CFR decreased from 5.4 to 2.6 deaths per 1000 cases of obstetric complications admitted during the program period. The very early neonatal mortality rate (deaths within 24 hours of birth) decreased by 21% (IRR 0.79; 95% CI, 0.65–0.96).ConclusionOur study suggests that overall obstetric case fatality and very early neonatal mortality rates—two indicators for tracking the quality of emergency obstetric care—decreased significantly at hospitals after the implementation of the EMAS intervention program in Indonesia.
The effect of Expanding Maternal and Neonatal Survival interventions on improving the coverage of labor monitoring and complication prevention practices in hospitals in Indonesia: A difference‐in‐difference analysis
Authors: Tholandi Maya , Sethi Reena , Pedrana Alisa , Qomariyah Situ Nurul , Amelia Dwirani , Kaslam Pancho , Sudirman Sudirman , Apriatni Mandri S. , Rahmanto Agus , Emerson Mark , Ahmed Saifuddin 
Published: February 2019

AbstractObjectiveTo assess whether the Expanding Maternal and Neonatal Survival (EMAS) program was associated with improved care provided during hospital‐based childbirth.MethodsA quasi‐experimental study with two rounds of data collection examined whether EMAS interventions improved facility‐based labor and childbirth care. Direct clinical observations were conducted for 1208 deliveries across 13 hospitals in 12 districts. Primary outcome measures included implementation of standard practices to reduce the risk of complications during labor and childbirth for both women and newborns.ResultsAdjusted difference‐in‐difference analysis compared the mean difference in quality scores between EMAS intervention hospitals and comparison sites and consistently found significantly better performance in EMAS sites: 14 points higher for labor monitoring (β‐coefficient 14.1; 95% confidence interval [CI], 7.1–21.0); 38 points higher for newborn resuscitation readiness (β‐coefficient 38.1; 95% CI, 31.1–45.2); and 33 points higher for infection prevention practices (β‐coefficient 32.6; 95% CI, 28.5–36.8).ConclusionEMAS approaches emphasizing facility readiness and adherence to performance standards significantly improved labor monitoring and complication prevention practices during childbirth.
Presence of doctors and obstetrician/gynecologists for patients with maternal complications in hospitals in six provinces of Indonesia
Authors: Pedrana Alisa , Tholandi Maya , Qomariyah Siti Nurul , Sethi Reena , Hyre Anne , Amelia Dwirani , Suhowatsky Stephanie , Ahmed Saifuddin 
Published: February 2019

AbstractObjectiveTo describe doctors’ and specialist physicians’ availability to manage obstetric complications in hospitals in six provinces of Indonesia.MethodsData from a nonrandomized, quasi‐experimental pre‐post evaluation study were used to describe the distribution of providers by each cadre of worker and assess the availability of doctors and obstetrician/gynecologists (ob/gyns) for consultations for women experiencing postpartum hemorrhage or pre‐eclampsia/eclampsia, disaggregated by hospital type, province, referral status, and by time of day of provider consultation.ResultsAmong hospitals that should have comprehensive emergency obstetric and newborn care (CEmONC) services available 24 hours a day, 7 days a week, many did not have a doctor available to manage obstetric complications as they presented, despite there being an average of seven ob/gyns and four doctors registered for service across all facilities. Slightly over 50% of obstetric emergency cases admitted with postpartum hemorrhage and severe pre‐eclampsia/eclampsia did not receive a consultation from an ob/gyn. Among the patients who received consultations, about 70% received consultations by phone or SMS.ConclusionFindings from this study indicate that persistent issues of maldistribution of maternal and newborn specialists and high absence rates of both doctors and ob/gyns at CEmONC hospitals during obstetric emergencies undermines Indonesia's efforts to reduce high maternal mortality rates.
Diallyl sulfide ameliorates carbon tetrachloride‐induced hepatotoxicity in rats via suppressing stress‐activated MAPK signaling pathways
Authors: Elkhoely Abeer 
Published: February 2019

AbstractThe underlined effects of diallyl sulfide (DAS) against CCL4‐induced oxidative, inflammatory, and apoptotic acute hepatic damage were assessed. Administration of DAS (50, 100, and 200 mg/kg) along with CCL
4 effectively mitigated serum aspartate aminotransferase, alanine aminotransferase activities, MDA, TNF‐α, IL‐1β, and MCP‐1 levels, as well as significantly restored HO‐1, GSH levels and SOD activity in liver tissues compared with those in rats treated with CCL
4. Moreover, DAS inhibited CCL
4‐induced increase of liver NF‐κB (p65), Bax, p38 MAPK, and JNK protein expression. In addition, DAS accelerated protein expression of Nrf2 and Bcl‐2. The hepatoprotective properties of DAS were further confirmed by the reduced severity of hepatic damage as demonstrated by histopathological findings. In conclusion, DAS achieved its protective potential against CCL4‐induced hepatotoxicity through antiapoptotic activity, as well as the synchronized modulation of NF‐κB and Nrf2 for the favor of antioxidant/anti‐inflammatory effects via suppression of the upstream stress‐activated MAPKs pathways.
Methylation of progesterone receptor isoform A promoter in normal breast tissue: An epigenetic link between early age at menarche and risk of breast cancer?
Authors: Daraei Abdolreza , Izadi Pantea , Khorasani Ghasemali , Nafissi Nahid , Naghizadeh Mohammad Mehdi , Younosi Nasim , Meysamie Alipasha , Mansoori Yaser , Nariman‐Saleh‐Fam Ziba , Bastami Milad , Saadatian Zahra , Zendehbad Zahra , Tavakkoly‐Bazzaz Javad 
Published: February 2019

AbstractEmerging evidence indicates that some altered patterns of methylation that occur in breast tumors may also be found in breast tissue of healthy women in relation to the breast cancer (BC) risk factors. Progesterone receptor (PR) isoform α is a crucial regulator of breast hormone responsiveness and its hypermethylation plays an important role in the initiation and development of breast tumors. However, such a methylation change in healthy women and its link with the different risk factors has not yet been investigated. In the present study, we aimed to examine the relationship of possible methylation changes within a critical region in the promoter CpG island of PGR‐α (progesterone receptor α) gene in the healthy women with a set of reproductive and nonreproductive BC risk factors. The breast tissues were collected from 120 cancer‐free women who had undergone cosmetic mammoplasty. The genomic DNA was extracted from the breast tissues and the methylation level of PGR‐α promoter CpG island was determined by using MeDIP‐qPCR assay. Using regression analysis, we found that increasing menarche age is inversely associated with the high methylation of PGR‐α promoter (
β = −0.790, SE = 0.362; P = 0.031). Although lactating women had more methylation than nonlactating women (P = 0.026, the t test), this result was not confirmed by regression models. Such an observation may be helpful in better understanding of the underlying mechanisms by which early age at menarche increases the risk of BC. However, this perspective requires further validations in larger studies of more subjects as well as the inclusion of other related genes.
Identification of UGP2 as a progression marker that promotes cell growth and motility in human glioma
Authors: Zeng Chun , Xing Wenli , Liu Yanhui 
Published: February 2019

AbstractGlioblastoma (GBM) is one of the most common highly malignant primary brain tumor with poor prognosis. This study aimed to explore the possible mechanism by bioinformatics method and detect potential function of UGP2 of GBM. Gene expression microarray data of GSE4412 and messenger RNA‐sequencing data of GBM with samples clinical information were downloaded from the Gene Expression Omnibus database and The Cancer Genome Atlas database, respectively. Differentially expressed genes (DEGs) analysis using the Kyoto Encyclopedia of Genes and Genomes and Gene Ontology based on R language. A total of 1000 common DEGs were identified in GBM samples, including 353 upregulated and 647 downregulated genes. Based on the random survival forest model, we identified UDP‐glucose pyrophosphorylase 2 (UGP2) (upregulated gene) had a significant effect on GBM prognosis. Functional enrichment showed that UGP2 was enriched in the biological progresses of cell proliferation, migration, and invasion. Furthermore, UGP2 expression is aberrantly overexpressed in human glioma and positively correlated with pathologic grade. A loss‐of‐function study showed that knockdown of UGP2 decreases U251 cell growth, migration, and invasion in vivo and vitro. We proposed the development and progression of human glioma were associated with survival based on bioinformatics analysis. We also found that UGP2 might function as prognostic markers in the pathogenesis of GBM.
Latent trajectories of change for clients at a psychodynamic training clinic
Authors: Jankowski Peter J. , Sandage Steven J. , Bell Chance A. , Rupert David , Bronstein Miriam , Stavros George S. 
Published: February 2019

AbstractObjectiveEmploying practice‐based research methods, we addressed the need to examine the effectiveness of psychodynamic treatment as a supplement to the efficacy evidence offered by randomized clinical trials.MethodWe used person‐centered analyses to generate latent subgroups of clients (N = 118;
M
age = 40.92; 53.4% female; 81.4% Caucasian; 80.5% heterosexual) receiving contemporary relational psychotherapy (CRP) at a psychodynamic community mental health training clinic.ResultsSubgroups of clients reported a change in depression, social conflict, and anxiety symptomatology, and overall life satisfaction, depicted by significant quadratic growth curves. Findings also offered exploratory support for a theoretical proposition from CRP that improved relational functioning would correspond to improved affect dysregulation and overall life satisfaction.ConclusionClinical and training implications highlight the need to distinguish subgroups of “responders” and “nonresponders” to inform treatment.
A Study to Evaluate Doravirine Pharmacokinetics When Coadministered With Acid‐Reducing Agents
Authors: Khalilieh Sauzanne G. , Yee Ka Lai , Sanchez Rosa I. , Fan Li , Vaynshteyn Kate , Deschamps Kathleen , Martell Maureen , Jordan Heather R. , Iwamoto Marian 
Published: February 2019

AbstractDoravirine is a novel non‐nucleoside reverse transcriptase inhibitor indicated for the treatment of human immunodeficiency virus type 1 infection. Because of potential concomitant administration with acid‐reducing agents, a drug‐interaction trial was conducted to evaluate the potential impact of these types of medications on doravirine pharmacokinetics. In an open‐label, 3‐period, fixed‐sequence trial, healthy adult participants received the following: period 1, a single dose of doravirine 100 mg; period 2, coadministration of a single dose of doravirine 100 mg and an antacid (1600 mg aluminum hydroxide, 1600 mg magnesium hydroxide, and 160 mg simethicone); period 3, 40 mg pantoprazole once daily on days 1–5 coadministered with a single dose of doravirine 100 mg on day 5. There was a minimum 10‐day washout between periods. Plasma samples for pharmacokinetic evaluation were collected, and safety was assessed. Fourteen participants (8 male, 6 female) were enrolled, and 13 completed the trial. Geometric mean ratios (90% confidence intervals) for doravirine AUC0‐inf, Cmax, and C24 for doravirine + antacid/doravirine were 1.01 (0.92–1.11), 0.86 (0.74–1.01), and 1.03 (0.94–1.12), respectively, and for doravirine + pantoprazole/doravirine were 0.83 (0.76–0.91), 0.88 (0.76–1.01), and 0.84 (0.77–0.92), respectively. Doravirine was generally well tolerated administered alone or with either of the acid‐reducing agents. Coadministration of an aluminum/magnesium‐containing antacid or pantoprazole did not have a clinically meaningful effect on doravirine pharmacokinetics, supporting the use of acid‐reducing agents with doravirine.
Team creativity/innovation in culturally diverse teams: A meta‐analysis
Authors: Wang Jie , Cheng Grand H.‐L. , Chen Tingting , Leung Kwok 
Published: February 2019

SummaryThis meta‐analysis investigates the direction and strength of the relationship between diversity in culturally diverse teams and team creativity/innovation. We distinguish the effects of two diversity levels (i.e., surface level vs. deep level) in culturally diverse teams and examine the moderators suggested by the socio‐technical systems framework (i.e., team virtuality and task characteristics in terms of task interdependence, complexity, and intellectiveness). Surface‐level diversity in culturally diverse teams is not related to team creativity/innovation, whereas deep‐level diversity in culturally diverse teams is positively related to team creativity/innovation. Moreover, surface‐level diversity in culturally diverse teams and team creativity/innovation are negatively related for simple tasks but unrelated for complex tasks. Deep‐level diversity in culturally diverse teams and team creativity/innovation is positively related for collocated teams and interdependent tasks but unrelated for noncollocated teams and independent tasks. We discuss the theoretical and practical implications.
Effects of intra‐articular hyaluronic acid associated to Chitlac (arty‐duo®) in a rat knee osteoarthritis model
Authors: Salamanna Francesca , Giavaresi Gianluca , Parrilli Annapaola , Martini Lucia , Nicoli Aldini Nicolò , Abatangelo Giovanni , Frizziero Antonio , Fini Milena 
Published: February 2019

ABSTRACTAmong conventional osteoarthritis (OA) treatments, intra‐articular (i.a) viscosupplementation with hyaluronic acid (HA) is used to restore joint viscoelasticity. However, the rapid clearance and elimination of HA may limit its application. The aim of this study was to verify the improved efficacy of HA within the joint, using a lactose‐modified chitosan (chitlac) as a potentially chondroprotective additive. Four weeks after induction of experimental OA by destabilization of the medial meniscus (DMM), 12‐week‐old Sprague Dawley male rats (n = 30), received once a week, for three weeks, i.a injections of: (i) HA associated to chitlac (ARTY‐DUO®), (ii) HA; and (iii) sodium chloride (NaCl). Five animals for each group were euthanized 4 weeks after the first i.a injection, while the remaining five were euthanized 8 weeks after the first i.a injection. The restoration of physiological joint microenvironment was tested by histology, histomorphometry, immunohistochemistry, and microtomography (micro‐CT). At 4 and even more at 8 weeks, histological analysis showed a significant decrease in OARSI and Mankin scores, with weaker matrix metalloproteinase (MMP)‐3, MMP‐13, and Galectin‐3 in ARTY‐DUO® group versus NaCl and HA groups. A reduction in Galectin‐1 and a stronger Collagen II staining was seen in both ARTY‐DUO® and HA versus NaCl. A reduction in Kreen‐modified score, for synovium inflammation, was observed in the ARTY‐DUO® group. Micro‐CT measurements did not shown significant differences between the groups. The present results show that i.a ARTY‐DUO® injections produce a significant improvement in knee articular cartilage degeneration and synovium inflammation in a rat model of DMM‐induced OA. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res