bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract A67: The effects of SAHA and EGCG on metastatic potential in triple-negative breast cancer
Authors: Lewis Kayla Ashlyn , Tollefsbol Trygve O. 
Published: February 2019

Abstract
Approximately 12% of breast cancers are triple negative, and are nearly two times more common in black women that white women. These cancers have a poorer short-term prognosis than other types due to the lack of targeted therapies. The purpose of this study was to use suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor used to treat cutaneous T cell lymphoma (CTCL), and epigallocatechin-3-gallate (EGCG), a DNA methyltransferase (DNMT) inhibitor found in green tea, to decrease metastatic potential in triple-negative breast cancer (TNBC) cells. SAHA and EGCG were administered singly and in combination to determine if the combination was more efficacious than either compound alone in their effects on cell viability and foci, or colony, formation. RNA and protein analysis was performed to evaluate epithelial versus mesenchymal markers, while scratch tests provided phenotypic evidence of changes in migration capability. We found that the combination of SAHA and EGCG at optimal concentrations of 3 μM SAHA and 5 μM reduced breast cancer cellular viability in an additive manner while this combination had no significant effect on control breast cells. This is a very low dose of EGCG compared to most anticancer studies. The colonies formed by the breast cancer cells decreased in size and number. Interestingly, EGCG administered singly increased colony formation. The combination of SAHA and EGCG also reactivated estrogen receptor alpha (ERα), and decreased the expression of miR-221/222, which are microRNAs involved in migration and invasion. The scratch tests supported these findings, with the breast cancer cells exhibiting a decreased ability to migrate. These findings demonstrate the abilities of combined SAHA and EGCG to decrease metastatic potential through epigenetic mechanisms in TNBC.
Citation Format: Kayla Ashlyn Lewis, Trygve O. Tollefsbol. The effects of SAHA and EGCG on metastatic potential in triple-negative breast cancer [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr A67.
Abstract A72: [Advocate Abstract:] Community initiatives for all women's health
Authors: Lucio Araceli 
Published: February 2019

Abstract
My poster will describe four community programs I have established at The Resurrection Project. The first focuses on breast cancer education workshops to address the lack of knowledge, cultural misconceptions, fear, and shame in my community and other underserved communities. The second focuses on breast cancer navigation to address the lack of insurance and cost issues in my community and in other underserved communities. The third focuses on breast cancer survivorship and empowerment to address the need for peer role models in my community and for other underserved communities. The fourth focuses on policy advocacy to address the need for resources for other underserved women.
Citation Format: Araceli Lucio. [Advocate Abstract:] Community initiatives for all women's health [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr A72.
Abstract A75: [Advocate Abstract:] Colorectal cancer and health disparities with African American population
Authors: Nalls Erika 
Published: February 2019

Abstract
This poster will focus on some of the specific challenges around colorectal cancer within African American communities. It will look at current statistics, barriers to better outcomes in the areas of screening, prevention and survivorship. It will also look at issue (controlled for income and education) and still lack of more positive outcomes.
All information provided will be evidence based. I have used information from Colon Cancer Alliance for a work event that I organized and will most likely use some of this again, along with other evidence-based research. It will also raise questions.
Citation Format: Erika Nalls. [Advocate Abstract:] Colorectal cancer and health disparities with African American population [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr A75.
Abstract B39: A pilot study of neuropsychological functions, APOE, and amyloid imaging in patients with gliomas
Authors: Correa Denise , Kryza-Lacombe Maria , Zhou Xiaosun , Baser Raymond , Beattie Brad , Beiene Zodina , Orlow Irene , Humm John , DeAngelis Lisa , Weber Wolfgang , Osborne Joseph 
Published: February 2019

Abstract
Patients with brain tumors treated with radiotherapy (RT) often develop cognitive dysfunction, and recent studies suggest that the apolipoprotein (APOE) ε-4 allele may influence cognitive outcome. The ε-4 allele promotes beta (β) amyloid deposition in the cortex, and preliminary evidence suggests that RT may be associated with β-amyloid deposition. In this pilot study, we assessed neuropsychological functions and β-amyloid retention using 18F-florbetaben PET in a subset of brain tumor patients who participated in our study of APOE polymorphisms and cognitive functions. Twenty glioma patients treated with conformal RT ± chemotherapy participated in the study: 6 were APOE ε-4 carriers and 14 were non-ε-4 carriers. Patients completed a neuropsychological reevaluation and brain MRI and 18F-florbetaben PET scans. The results of Wilcoxon rank sums test comparisons between prior and current assessments showed a significant decline in selective attention (Brief Test of Attention, p=0.018), and a near-significant decline in verbal learning (Hopkins Verbal Learning Test-Learning, p=0.07). Comparisons between assessments by APOE status showed a significant decline in attention and working memory (WAIS-III digits forward, p=0.028 and digits backward, p=0.032) among APOE ε-4 carriers. Comparisons of PET regional standard uptake value ratios (SUVRs) showed near-significant differences for the medial temporal cortex (p=0.069) and the putamen (p=0.069), with non-ε-4 carriers having higher SUVRs. The findings suggest that glioma patients may experience progressive worsening in attention and executive functions several years after treatment with RT ± chemotherapy, and that the APOE ε-4 allele may moderate cognitive decline.
Note: This abstract was not presented at the conference.
Citation Format: Denise Correa, Maria Kryza-Lacombe, Xiaosun Zhou, Raymond Baser, Brad Beattie, Zodina Beiene, Irene Orlow, John Humm, Lisa DeAngelis, Wolfgang Weber, Joseph Osborne. A pilot study of neuropsychological functions, APOE, and amyloid imaging in patients with gliomas [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr B39.
Abstract B57: Distinct genomic alterations in prostate cancer of African American men
Authors: Dobi Albert , Petrovics Gyorgy , Li Hua , Young Denise , Chen Yongmei , Kagan Jacob , Srivastava Sudhir , Ebner Reinhard , Rosner Inger L. , Cullen Jennifer , Freedman Matthew L. , Sesterhenn Isabell A. , Szallasi Zoltan , Srivastava Shiv 
Published: February 2019

Abstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR01) of the Conference Proceedings.
Note: This abstract was not presented at the conference.
Citation Format: Albert Dobi, Gyorgy Petrovics, Hua Li, Denise Young, Yongmei Chen, Jacob Kagan, Sudhir Srivastava, Reinhard Ebner, Inger L. Rosner, Jennifer Cullen, Matthew L. Freedman, Isabell A. Sesterhenn, Zoltan Szallasi, Shiv Srivastava. Distinct genomic alterations in prostate cancer of African American men [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr B57.
Abstract C12: Cancer navigation programs: Identifying barriers and addressing health disparities in Appalachia
Authors: Dwyer Sharon , Rohan Elizabeth , White Dana , Stockton Eric , Castro Georgina , Wilson Reda , White Carol , Dignan Mark 
Published: February 2019

Abstract
The Appalachian region includes 13 states comprising 420 counties, beginning in the north in southern New York and following the Appalachian Mountains to Mississippi. The region has unique natural beauty and a heterogeneous population that shares distinct cultural characteristics but with high rates of unemployment, low income, and high rates of chronic disease, including cancer. Patient Navigation (PN) can address barriers and enhance access to cancer screening and care through the use of individual navigators who are sensitive to the needs, interests, and values of the community. Although there are numerous PN training programs available, there are no known programs specific to the Appalachian population. An electronic survey was distributed in 2011 and again in 2015/16 to better understand the cancer navigation programs in all 13 states of the Appalachian states and how they serve the regional population. In both waves of the survey over 150 responses were received from navigators, program directors, and supervisors. Survey results identify where cancer navigation programs take place (hospitals, health centers, and cancer centers), which health professionals fill the role of navigators (social workers, nurses, health educators), where navigation programs reside in health organizations (breast care centers, infusion centers, social services, and cancer centers), what aspects of the cancer continuum are addressed (prevention, screening, treatment to survivorship), and what range of services are provided by navigation programs (from education, referrals, to financial and spiritual support). A summary and comparison of quantitative data will be reported supplemented with qualitative findings and open-ended responses.
Citation Format: Sharon Dwyer, Elizabeth Rohan, Dana White, Eric Stockton, Georgina Castro, Reda Wilson, Carol White, Mark Dignan. Cancer navigation programs: Identifying barriers and addressing health disparities in Appalachia [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr C12.
Abstract C32: [Advocate Abstract:] Survivorship and African American women diagnosed with MBC
Authors: Florence Yvonne McLean 
Published: February 2019

Abstract
The poster will highlight the state of survival for African American women diagnosed with MBC.
Citation Format: Yvonne McLean Florence. [Advocate Abstract:] Survivorship and African American women diagnosed with MBC [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr C32.
Abstract C51: Definitive radiation therapy for cervical cancer: Race as a risk factor for delayed completion, preliminary findings
Authors: Petersen Shariska , Davydov Dmitry , Davydova Yafa , FitzGerald Michael , Buekers Thomas 
Published: February 2019

Abstract
Objective: To assess whether racial disparities exist in time to completion of external beam pelvic radiation therapy and brachytherapy in cervical cancers treated with definitive chemoradiation.
Methods: A retrospective analysis was conducted on all cervical cancer patients treated with definitive radiotherapy between 2006 and 2016. Analyses were performed according to the following distinct definitions of wait times: interval from pathologic diagnosis of cervical cancer to (1) initiation of radiation therapy, (2) completion of external beam radiation therapy, and (3) completion of brachytherapy. The duration of external beam radiation therapy and brachytherapy was also calculated.
Results: A total of 50 women underwent primary external beam pelvic radiation therapy for cervical cancer at our institution over a 10-year period. Of 50 women, 21 self-identified as White, 25 as African-American (AA), and 4 as Hispanic. Due to small numbers, Hispanic women were excluded. Thus, a total of 46 patients were analyzed. The average age was 52 years for both White and AA women in this cohort.
Mean days to initiation of radiation therapy was 42.5 days: 33.7 days (median 32 days) among White patients versus 49.8 days (median 40 days) for AA patients (p-value 0.058). Mean days from diagnosis to completion of pelvic radiation therapy was 81.4 days: 70.9 days (median 69 days) among White patients versus 90.3 days (median 84 days) among AA (p-value 0.026). Mean days from diagnosis to completion of brachytherapy were noted to be 87.1 days for White patients and 103.7 days for AA patients (p-value 0.035). The duration of ERBT and brachytherapy was 57.2 for White patients and 56.6 for AA patients (p-value 0.818).
Conclusion: African-American patients experienced delays to initiating radiation therapy, which resulted in delays to completing external beam radiation and brachytherapy. However, there was no difference in the duration of treatment between groups. Therefore, we conclude that once patients begin treatment, they complete treatment within the similar time frame of 57 days regardless of race. Studies to determine the effect of delayed initiation on survival outcomes are under way. Directed patient navigation programs may be helpful to decrease the delay to initiating radiation therapy for African-American patients.
Citation Format: Shariska Petersen, Dmitry Davydov, Yafa Davydova, Michael FitzGerald, Thomas Buekers. Definitive radiation therapy for cervical cancer: Race as a risk factor for delayed completion, preliminary findings [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr C51.
Abstract C60: The role of psychosocial predictors in HBV screening behavior among Vietnamese Americans
Authors: Lee Minsun , Zhu Lin , Wang Min Qi , Wei Zhengyu , Tan Yin , Nguyen Minhhuyen , Ogunwobi Olorunseun O. , Ma Grace X. 
Published: February 2019

Abstract
Objectives: Given the substantial disparity in hepatitis B virus (HBV) infection among Vietnamese Americans, it is important to understand what intervention components facilitate behavioral change. In this study, we evaluated the influence of psychosocial factors on HBV screening.
Methods: The study sample consists of 1,716 Vietnamese participants in our HBV intervention trial, recruited from 36 community-based organizations in Pennsylvania, New Jersey, and New York City between 2009 and 2014. Using Health Belief Model and Social Cognitive Theory, we measured self-efficacy, knowledge, perceived barriers, perceived benefits, perceived severity, and risk susceptibility. Analysis of covariance (ANCOVA) was used to compare pre- and post-intervention changes of psychosocial variables. Structural equation modeling (SEM) was used to explore the direct and indirect effects of the psychosocial variables on HBV screening.
Results: Knowledge, self-efficacy, perceived benefits, and perceived barriers were directly associated with HBV screening, with knowledge having the strongest effect. Perceived severity and risk susceptibility had indirect association with HBV screening through other variables. Indirect paths among the 6 psychosocial variables were also identified.
Conclusions: To promote HBV screening among Vietnamese Americans, intervention efforts should focus on increasing knowledge, self-efficacy, and perceived benefits; decreasing perceived barriers; and account for the dynamic cognitive processing.
Citation Format: Minsun Lee, Lin Zhu, Min Qi Wang, Zhengyu Wei, Yin Tan, Minhhuyen Nguyen, Olorunseun O. Ogunwobi, Grace X. Ma. The role of psychosocial predictors in HBV screening behavior among Vietnamese Americans [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr C60.
Abstract C62: Sub-Saharan African immigrant men's knowledge and support related to cervical cancer screening: A qualitative descriptive study
Authors: Adegboyega Adebola , Hatcher Jennifer 
Published: February 2019

Abstract
Background: Cervical cancer screening disparity puts sub-Saharan African immigrant women at an increased risk for development of invasive cervical cancer. Several studies have identified various factors influencing cervical cancer screening use among sub-Saharan African immigrants in the United States. One of such factors is the role of spousal support; African men are often the gatekeepers of health for their families and have significant influence on the health-seeking behavior of their wives/female partners. However, limited research exists on men's knowledge and support related to Pap screening. Thus, we conducted a qualitative descriptive study to assess knowledge and support related to Pap screening among sub-Saharan African immigrant men in Lexington, Kentucky.
Method: In-depth individual interviews using semistructured guide were conducted with 21 sub-Saharan African immigrant men who were married or in committed relationships. Data were audio recorded, transcribed verbatim, and analyzed using content analysis.
Results: The average age of the study participants was 36 ± 9; 53% have lived in the US for more than 5 years; 88% were college educated; 43% make more than $50,000 annually; and 62% were married. General knowledge of Pap screening, cervical cancer, and HPV's role in the etiology of cervical cancer was minimal. Men showed the desire to support their wives/female partners to have a Pap screening. All participants preferred to be carried along and informed about their wives' decision to have a Pap screening in order to provide any support that might be needed. The narratives related to health care providers' gender preference varied among men; several men showed preference for a female health care provider for Pap screening services for their wives/female partners while others showed no preference.
Conclusions: These findings underscore the importance of men's support in promoting Pap screening among sub-Saharan African immigrant women. Men should be included in cervical cancer prevention efforts to leverage their support. Thorough understanding of African family dynamics, cultural norms, and values related to preventive health care seeking is essential to the design and implementation of interventions for improving Pap screening among sub-Saharan African immigrant women.
Citation Format: Adebola Adegboyega, Jennifer Hatcher. Sub-Saharan African immigrant men's knowledge and support related to cervical cancer screening: A qualitative descriptive study [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr C62.
Abstract C79: Examining the role of cultural competence in mammography adherence: Perceptions of African American residents of Harris County, Texas
Authors: Hall Marla B. , Guidry Jeffrey J. , Jones Lovell A. 
Published: February 2019

Abstract
Breast cancer mortality has affected African American women at a disproportionate rate. There are various factors contributing to this outcome, with medical mistrust identified as a significant determinant of screening adherence. The purpose of this research was to assess how perceptions of health professionals' cultural competence influenced African American women's barriers to and receipt of mammograms. To recruit participants, researchers first identified locations with large proportions of African American persons. This included grocery stores, local community centers, churches, strip malls, hair salons, and restaurants. At each site, significant efforts were made to personally interact with community members. Personal interaction included, as often as possible, matching the race/ethnicity and gender of the research team member with the potential participant. Sixty-one African American women residing in Harris County, Texas, shared their views within a series of focus groups. Participants noted various factors associated with mammography compliance. Firstly, lack of professionalism among clinicians and clerical staff caused a decrease in health care services utilization and procedural adherence. In addition, cultural insensitivity and discriminatory behavior strengthened attitudes of medical mistrust. Therefore, improving patient–provider communication, through culturally appropriate capacity building initiatives, is a beneficial strategy to facilitate healthful engagement of medically underserved and racial/ethnic minority populations.
Citation Format: Marla B. Hall, Jeffrey J. Guidry, Lovell A. Jones. Examining the role of cultural competence in mammography adherence: Perceptions of African American residents of Harris County, Texas [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr C79.
Abstract IA13: Understanding cancer disparities in mortality and survivorship and social and built environments
Authors: Shariff-Marco Salma 
Published: February 2019

Abstract
Neighborhoods have been shown to influence health outcomes through a number of pathways--environmental exposures, material deprivation (e.g., inadequate housing), psychosocial mechanisms (e.g., stress and social support), health behaviors (e.g., physical activity, smoking, diet), and access to resources--factors that likely impact mortality and survivorship after a cancer diagnosis. Using data from the California Neighborhoods Data System to characterize the social and built environments, this presentation will include findings from two studies examining associations between neighborhood and cancer mortality as well as health-related quality of life across diverse populations. In addition, this presentation will highlight methods for characterizing the social and built environments for cancer outcomes studies, including the use of latent class analyses for developing neighborhood archetypes. Assessing the impact of the social and built environments on cancer outcomes is the first step towards accounting for and addressing neighborhood context in cancer-survivorship trajectories.
Citation Format: Salma Shariff-Marco. Understanding cancer disparities in mortality and survivorship and social and built environments [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr IA13.