bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescent Sugar-Sweetened Beverage Intake is Associated With Parent Intake, Not Knowledge of Health Risks
Authors: Lundeen Elizabeth A. , Park Sohyun , Onufrak Stephen , Cunningham Solveig , Blanck Heidi M. 
Published: April 2018

Purpose: To examine associations of adolescent sugar-sweetened beverage (SSB) intake with parent SSB intake and parent and adolescent knowledge of SSB-related health risks. Design: Quantitative, cross-sectional. Setting: 2014 SummerStyles survey. Subjects: Nine hundred and ninety parent and adolescent (12-17 years) pairs. Measures: The outcome was self-reported adolescent intake (0, >0 to <1, or ≥1 time/day) of SSBs (soda, fruit drinks, sports/energy drinks, other SSBs). The exposures were self-reported parent SSB intake (0, >0 to <1, ≥1 to <2, or ≥2 times/day) and parent and adolescent knowledge of SSB-related health risks (weight gain, diabetes, and dental caries). Analysis: Separate multinomial logistic regression models were used to estimate adjusted odds ratios (aORs) for adolescent SSB intake ≥1 time/day (ref: 0 times/day), according to (1) parent SSB intake and (2) parent and (3) adolescent knowledge. Results: About 31% of adolescents consumed SSBs ≥1 time/day, and 43.2% of parents consumed SSBs ≥2 times/day. Adolescent and parent knowledge that SSB intake is related to health conditions ranged from 60.7% to 80.4%: weight gain (75.0% and 80.4%, respectively), diabetes (60.7% and 71.4%, respectively), and dental caries (77.5% and 72.9%, respectively). In adjusted models, adolescent SSB intake ≥1 time/day was associated with parent intake ≥2 times/day (aOR = 3.30; 95% confidence interval = 1.62-6.74) but not with parent or adolescent knowledge of health risks. Conclusion: Parental SSB intake may be an important factor in understanding adolescent behavior; knowledge of SSB-related health conditions alone may not influence adolescent SSB behavior.
The third New Zealand Psychiatry of Old Age services and workforce survey
Authors: Cheung Gary , Sims Adam , Copeland Bronwyn , Collins Chris , Bharathan Sires 
Published: April 2018

Objective: To survey the Psychiatry of Old Age (POA) services and workforce in New Zealand (NZ). Methods: The NZ branch of Faculty of POA contacted the POA lead clinician and/or service manager of the 20 district health boards (DHBs) and completed a survey based on variables used in two similar previous national surveys. Results: Seventeen services responded. We found acute inpatient beds and clinical staff time are funded differently across DHBs. Although there has been an increase in non-medical clinical staff time in the community teams, most DHBs are not planning to increase their medical staff time in the next 3 years. Specialist services for people with intellectual disabilities and young-onset dementia, and older people with substance use disorder are generally not provided within POA services. Conclusions: A wider POA and non-POA services mapping is required to determine the level of services for clinical populations that have high and complex clinical needs. DHB funders should review the expected population growth in people aged 65+ and consider increasing the funding for these under-served clinical populations.
Outcome of pediatric cataract surgery with intraocular injection of triamcinolone acetonide: Randomized controlled trial
Authors: Allam Ghada , Ellakkany Rasheed , Ellayeh Adel , Mohsen Tarek , Abouelkheir Hossam ElDin , Gaafar Walid 
Published: April 2018

Purpose: To evaluate the use of intraocular injection of triamcinolone acetonide in pediatric cataract surgery with or without intraocular lens implantation as a vitreous dye to ensure a complete anterior vitrectomy and evaluate its effect on postoperative ocular inflammation, infection, posterior capsule opacification, and intraocular pressure. Methods: Randomized controlled trial included children diagnosed with bilateral congenital cataract in both eyes. Their eyes were randomly assigned into two groups: group A underwent aspiration, posterior capsulotomy, and anterior vitrectomy with intraocular injection of triamcinolone acetonide, while group B underwent the same surgical procedure without intraocular injection of triamcinolone acetonide. Intraocular pressure, postoperative inflammation, infection, and posterior capsule opacification were followed up till 6 months. Results: The study comprised 44 eyes of 22 children. The mean age was 2.4 ± 2.1 years including 10 males and 12 females. The mean postoperative intraocular pressure was within normal range in both groups. No case of infection in both groups. No eyes in group A showed reaction, while in group B, three eyes showed exudate on the first day, which improved at 2 weeks. Posterior synechiae was recorded in four eyes in group A and in five eyes in group B. Posterior capsule opacification was noted in one eye in group A at 3 month, while it was noted in nine eyes in group B. The difference was statistically significant ( p = 0.004). Conclusion: Triamcinolone acetonide was found to be useful in better visualization of vitreous in pediatric cataract surgery and has good effect in decreasing postoperative inflammation and posterior capsule opacification.
Upregulation of MiR-212 Inhibits Migration and Tumorigenicity and Inactivates Wnt/β-Catenin Signaling in Human Hepatocellular Carcinoma
Authors: Jia Pengbo , Wei Guangbing , Zhou Cancan , Gao Qi , Wu Yunhua , Sun Xuejun , Li Xuqi 
Published: April 2018

Background: MicroRNAs are involved in hepatocellular carcinoma metastasis, a principal cause of hepatocellular carcinoma–related death in patients worldwide. MiR-212 is a microRNA that has been identified in several types of cancers and is postulated to influence cell signaling and subsequent malignant pathogenesis. Despite emerging reports suggesting that miR-212 plays a significant role in the onset, progression, and migration of these types of malignant tumors, its involvement in the development of hepatocellular carcinoma has not been fully elucidated. Materials and Methods: Quantitative reverse transcription polymerase chain reaction, wound healing, transwell migration and invasion assays, Western blotting, and xenograft tumor growth models were performed to test the expression levels and functions of miR-212 in hepatocellular carcinoma. Luciferase reporter assay, quantitative reverse transcription polymerase chain reaction, Western blotting, and immunohistochemistry were used to identify and verify the target of miR-212. Results: In this study, we identify significant repression of miR-212 in hepatocellular carcinoma and demonstrate that overexpression of miR-212 inhibits the migration of hepatocellular carcinoma cells in vitro and in vivo. Furthermore, we identify forkhead box M1, whose expression is inversely related to that of miR-212, as a direct target of miR-212. Additionally, reexpression of forkhead box M1 rescues the miR-212-mediated inhibition of cell migration. We observed that inhibition of miR-212 activates forkhead box M1 but inhibits the Wnt/β-catenin pathway by suppressing Wnt, LEF-1, c-Myc, and nuclear β-catenin. Finally, in vivo studies confirmed the inhibitory effect of miR-212 on hepatocellular carcinoma growth. Conclusion: Our present findings indicate that miR-212 is a potential prognostic biomarker of hepatocellular carcinoma and that the miR-212/forkhead box M1 regulatory axis may represent a new therapeutic objective for hepatocellular carcinoma treatment.
Soul Projects: Class-Related Spiritual Practices in Higher Education
Authors: Wilhoit James C. , Setran David P. , Ratcliff Donald , Haase Daniel T. , Rosema Linda 
Published: April 2018

In recent years, scholars have urged those working in Christian higher education to attend more purposefully to student spiritual and character formation. Anchored by the belief that college is a formative time for the development of values, commitments, identity, and life purpose, these calls have taken many different forms. One consistent theme, however, has been the need to expand character formation beyond ethical training and moral decision-making. While such tools are necessary, these scholars note, there is also a pressing need for the development of righteous virtues, affections, commitments, and patterns of living rooted in a right understanding of God and self. How can professors encourage spiritual attentiveness and transformation within the academic setting of a college classroom? What assignments foster spiritual focus and growth into Christlikeness? What helpful practices from the historic Christian tradition can be included in syllabi and course experiences? As professors committed to educationally-based spiritual formation, we are concerned with how to best encourage student spiritual growth. This article is the culmination of conversations, as well as trial and error in our classrooms, in an attempt to answer these questions.
Con-formed to Christ: Dietrich Bonhoeffer and Christian Formation
Authors: McGarry Joseph 
Published: April 2018

This essay offers an overview of Dietrich Bonhoeffer's distinct theology of conformation in Christ. His work is unique both in form and content. Formally, Bonhoeffer, as a systematic theologian, emphasizes doctrinal relationships as well as biblical exegesis. This leads him to develop a distinct content of Christian formation. This essay investigates how he works and the specific benefits of an exhaustive theological accounting of formation in Christ. To do this, this essay investigates Bonhoeffer's “upstream” theological commitments, beginning with anthropology, in order to illumine his distinct starting position. These are then put into conversation with doctrines of sanctification and holiness to draw attention to their import for Christian formation. It will then review Bonhoeffer's unique understanding of conformation in Christ and what it means for Christ to take form among the community. All of this will be done in order to place him in conversation with more dominant models of formation and look forward to how his theology might push the current dialogue further.
Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia
Authors: Gökbuget Nicola , Dombret Hervé , Bonifacio Massimiliano , Reichle Albrecht , Graux Carlos , Faul Christoph , Diedrich Helmut , Topp Max S. , Brüggemann Monika , Horst Heinz-August , Havelange Violaine , Stieglmaier Julia , Wessels Hendrik , Haddad Vincent , Benjamin Jonathan E. , Zugmaier Gerhard , Nagorsen Dirk , Bargou Ralf C. 
Published: April 2018

AbstractApproximately 30% to 50% of adults with acute lymphoblastic leukemia (ALL) in hematologic complete remission after multiagent therapy exhibit minimal residual disease (MRD) by reverse transcriptase–polymerase chain reaction or flow cytometry. MRD is the strongest predictor of relapse in ALL. In this open-label, single-arm study, adults with B-cell precursor ALL in hematologic complete remission with MRD (≥10−3) received blinatumomab 15 µg/m2 per day by continuous IV infusion for up to 4 cycles. Patients could undergo allogeneic hematopoietic stem-cell transplantation any time after cycle 1. The primary end point was complete MRD response status after 1 cycle of blinatumomab. One hundred sixteen patients received blinatumomab. Eighty-eight (78%) of 113 evaluable patients achieved a complete MRD response. In the subgroup of 110 patients with Ph-negative ALL in hematologic remission, the Kaplan-Meier estimate of relapse-free survival (RFS) at 18 months was 54%. Median overall survival (OS) was 36.5 months. In landmark analyses, complete MRD responders had longer RFS (23.6 vs 5.7 months; P = .002) and OS (38.9 vs 12.5 months; P = .002) compared with MRD nonresponders. Adverse events were consistent with previous studies of blinatumomab. Twelve (10%) and 3 patients (3%) had grade 3 or 4 neurologic events, respectively. Four patients (3%) had cytokine release syndrome grade 1, n = 2; grade 3, n = 2), all during cycle 1. After treatment with blinatumomab in a population of patients with MRD-positive B-cell precursor ALL, a majority achieved a complete MRD response, which was associated with significantly longer RFS and OS compared with MRD nonresponders. This study is registered at www.clinicaltrials.gov as #NCT01207388.
Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update
Authors: Oktay Kutluk , Harvey Brittany E. , Partridge Ann H. , Quinn Gwendolyn P. , Reinecke Joyce , Taylor Hugh S. , Wallace W. Hamish , Wang Erica T. , Loren Alison W. 
Published: April 2018

Purpose To provide current recommendations about fertility preservation for adults and children with cancer. Methods A systematic review of the literature published from January 2013 to March 2017 was completed using PubMed and the Cochrane Library. An Update Panel reviewed the identified publications. Results There were 61 publications identified and reviewed. None of these publications prompted a significant change in the 2013 recommendations. Recommendations Health care providers should initiate the discussion on the possibility of infertility with patients with cancer treated during their reproductive years or with parents/guardians of children as early as possible. Providers should be prepared to discuss fertility preservation options and/or to refer all potential patients to appropriate reproductive specialists. Although patients may be focused initially on their cancer diagnosis, providers should advise patients regarding potential threats to fertility as early as possible in the treatment process so as to allow for the widest array of options for fertility preservation. The discussion should be documented. Sperm, oocyte, and embryo cryopreservation are considered standard practice and are widely available. There is conflicting evidence to recommend gonadotrophin-releasing hormone agonists (GnRHa) and other means of ovarian suppression for fertility preservation. The Panel recognizes that, when proven fertility preservation methods are not feasible, and in the setting of young women with breast cancer, GnRHa may be offered to patients in the hope of reducing the likelihood of chemotherapy-induced ovarian insufficiency. GnRHa should not be used in place of proven fertility preservation methods. The panel notes that the field of ovarian tissue cryopreservation is advancing quickly and may evolve to become standard therapy in the future. Additional information is available at www.asco.org/survivorship-guidelines .
Gesner Oliveira
Authors: Goldbaum Sérgio 
Published: April 2018

O ex-presidente do Cade e professor da FGV-EAESP discute as perspectivas de evolução da defesa da concorrência no país, que incluem o combate maisduro aos cartéis, a melhor articulação com as agências regulatórias e o avanço nos acordos multilaterais. Também examina o papel que o Brasil pode exercer nas discussões de fóruns como a Organização Mundial do Comércio – OMC.
A pesquisa que o país precisa
Authors: Cruz Carlos Henrique de Brito 
Published: April 2018

Ao mesmo tempo em que a capacidade brasileira de fazer ciência tem crescido e aumentado de peso no cenário internacional, a capacidade de produzir tecnologia mostrase substancialmente menor no país. A análise das atividades de pesquisa e desenvolvimento – P&D – no Brasil, com ênfase no papel de cada uma das instituições envolvidas – a universidade, a empresa e o governo – pode definir caminhos para impulsionar esse importante fator de desenvolvimento.
A irracionalidade das bolhas
Authors: Caselani César Nazareno 
Published: April 2018

Tradicionalmente, a teoria econômica pressupõe que os indivíduos seguem os princípios da racionalidade e tomam decisões levando sempre em conta o conceito de maximização do valor. Contudo, cabe questionar se os investidores se comportam de forma perfeitamente racional. Este artigo examina um dos exemplos mais marcantes de uma possível irracionalidade dos mercados financeiros: a ocorrência das chamadas bolhas especulativas.
O relógio controlado
Authors: Tonelli Maria José 
Published: April 2018

Trabalhar de 12 a 14 horas por dia virou rotina para executivos em todo o mundo. No Brasil, um mercado de trabalho restrito e seletivo levou aoaumento do número de tarefas e das responsabilidades atribuídas aos profissionais. Pressionados pela constante ameaça de desemprego e buscando responder a elevados padrões de excelência, os executivoslocais desdobram-se em jornadas frenéticas e intermináveis.
Ócio indesejável
Authors: Turolla Frederico A. , Fujiwara Thomas 
Published: April 2018

A questão emprego apresenta um quadro contraditório: de um lado, inúmeros pesquisadores apontam “o fim do emprego”; de outro, economistas e formuladores de políticas públicas se esmeram em advogar a importância de gerar empregos. Este artigo apresenta mitos e verdades sobre a criação de empregos no Brasil, e aponta alternativas para a minimização do problema do desemprego.
Criando valor sustentável
Authors: Hart Stuart L. , Milstein Mark B. 
Published: April 2018

Apesar da recente disseminação do discurso da sustentabilidade, grande parte dos executivos ainda considera o desenvolvimento sustentável uma espécie de mal necessário, uma vez que envolve regulações, custos e responsabilidades onerosas. Este artigo apresenta um modelo complexo e multifacetado de criação de valor para os acionistas que leva em conta os desafios globais do desenvolvimento sustentável. Mostra, que a sustentabilidade não é irreconciliável com o crescimento econômico, mas que, ao contrário, pode ser importante fonte de vantagem competitiva e de geração de valor para acionistas e comunidade em geral.
Relationships between full-day arm movement characteristics and developmental status in infants with typical development as they learn to reach: An observational study
Authors: Shida-Tokeshi Joanne , Lane Christianne J. , Trujillo-Priego Ivan A. , Deng Weiyang , Vanderbilt Douglas L. , Loeb Gerald E. , Smith Beth A. 
Published: April 2018

Background:Advances in wearable sensor technology now allow us to quantify the number, type and kinematic characteristics of bouts of infant arm movement made across a full day in the natural environment. Our aim here was to determine whether the amount and kinematic characteristics of arm movements made across the day in the natural environment were related to developmental status in infants with typical development as they learned to reach for objects using their arms.Methods:We used wearable sensors to measure arm movement across days and months as infants developed arm reaching skills. In total, 22 infants with typical development participated, aged between 38 and 203 days. Of the participants, 2 infants were measured once and the other 20 infants were measured once per month for 3 to 6 visits. The Bayley Scales of Infant Development was used to measure developmental level.Results:Our main findings were: 1) infant arm movement characteristics as measured by full-day wearable sensor data were related to Bayley motor, cognitive and language scores, indicating a relationship between daily movement characteristics and developmental status; 2) infants who moved more had larger increases in language and cognitive scores across visits; and 3) larger changes in movement characteristics across visits were related to higher motor scores.Conclusions:This was a preliminary, exploratory, small study of the potential importance of infant arm movement characteristics as measured by full-day wearable sensor data. Our results support full-day arm movement activity as an area of interest for future study as a biomarker of neurodevelopmental status and as a target for early intervention.
A community-based parent-support programme to prevent child maltreatment: Protocol for a randomised controlled trial
Authors: Furlong Mairead , McGilloway Sinead , Stokes Ann , Hickey Grainne , Leckey Yvonne , Bywater Tracey , O’Neill Ciaran , Cardwell Chris , Taylor Brian , Donnelly Michael ,   ENRICH Research Team
Published: April 2018

The prevention of child abuse and neglect is a global public health priority due to its serious, long-lasting effects on personal, social, and economic outcomes. The Children At Risk Model (ChARM) is a wraparound-inspired intervention that coordinates evidence-based parenting- and home-visiting programmes, along with community-based supports, in order to address the multiple and complex needs of families at risk of child abuse or neglect. The study comprises a multi-centre, randomised controlled trial, with embedded economic and process evaluations. The study is being conducted in two child-welfare agencies within socially disadvantaged settings in Ireland. Families with children aged 3-11 years who are at risk of maltreatment (n = 50) will be randomised to either the 20-week ChARM programme (n = 25) or to standard care (n = 25) using a 1:1 allocation ratio. The primary outcomes are incidences of child maltreatment and child behaviour and wellbeing. Secondary outcomes include quality of parent-child relationships, parental stress, mental health, substance use, recorded incidences of substantiated abuse, and out-of-home placements. Assessments will take place at pre-intervention, and at 6- and 12-month follow-up periods. The study is the first evaluation of a wraparound-inspired intervention, incorporating evidence-based programmes, designed to prevent child abuse and neglect within intact families. The findings offer a unique contribution to the development, implementation and evaluation of effective interventions in the prevention of child abuse and neglect. The trial is registered with the International Standard Randomised Controlled Trial Number Register (DOI 10.1186/ISRCTN13644600, Date of registration: 3rd June 2015).
STRATEGI KERUANGAN UNTUK MENINGKATKAN AKSES MASYARAKAT KELURAHAN TAMBAKJATI KABUPATEN SUBANG TERHADAP AIR BERSIH
Authors: Maryati Sri 
Published: April 2018

Kelurahan Tambakjati merupakan salah satu kelurahan di Kabupaten Subang yang mengalami kesulitandalam penyediaan air bersih. Sumber air di Kelurahan Tambakjati pada dasarnya berlimpah, namunmasyarakat tidak mempunyai akses yang cukup baik terhadap sumber air tersebut. Keterbatasan akses inidisebabkan karena untuk memperoleh air bersih dari sumber yang berlimpah tersebut diperlukan biayainvestasi dan operasi yang cukup tinggi, namun disisi lain kemampuan ekonomi masyarakat sangat rendah.Oleh karena itu dalam upaya penyediaan air bersih di Kelurahan Tambakjati perlu adanya intervensi daripemerintah. Mengingat kemampuan masyarakat yang rendah, penyediaan air bersih diupayakan agar tetapdapat bersifat cost recovery, sehingga diperlukan sejumlah strategi untuk menyesuaikan biaya penyediaan air bersih dengan kemauan membayar masyarakat. Penelitian ini bertujuan untuk menganalisis sejumlah strategi keruangan dalam penyediaan air bersih untuk menyesuiakan biaya penyediaan air bersih dengan kemauan membayar masyarakat.