bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse Events Associated With Antibiotics and Intravenous Therapies for Post–Lyme Disease Syndrome in a Commercially Insured Sample
Authors: Goodlet Kellie J , Fairman Kathleen A 
Published: April 2018

Abstract

Background
Non-guideline-endorsed posttreatment courses of antibiotics for post–Lyme disease syndrome (PLDS) have been linked to adverse patient outcomes, but these findings have yet to be validated in large systematic evaluations.

Methods
A retrospective cohort analysis of medical and pharmacy claims derived from the Truven Health Market Scan Commercial Claims and Encounters Database assessed 90-day incidence rates of adverse events (AEs) associated with PLDS treatment (PLDS-Tx). Patients were diagnosed with PLDS ≥6 months after initial diagnosis and standard antibiotic treatment for Lyme disease. Comparison cohorts included intravenous (IV) PLDS-Tx with or without oral antibiotics; oral antibiotic–only PLDS-Tx; or neither.

Results
Composite AE incidence rates were higher for patients treated with IV or oral PLDS-Tx than for patients not receiving either treatment (18.7%, 16.8%, and 13.4%, respectively; P = .019). Significant between-group differences in AE incidence rates were noted for electrolyte imbalance (4.0%, 1.5%, and 0.7%, respectively; P = .001) and infection (14.0%, 12.7%, and 9.3%; P = .006). Infection prevalence increased by 22.0% in the IV treatment group and 17.7% in the oral group. Incidence rates for all-cause and AE-related hospital stays and emergency department visits were higher for treated than nontreated patients, particularly when treatment was IV (all P &lt; .01). Of IV-treated patients, 7.3% experienced an incident all-cause inpatient stay and 11.3% an incident all-cause emergency department visit, compared with, respectively, 2.2% and 3.4% of those treated with oral antibiotics and 0.9% and 1.9% of nontreated patients.

Conclusions
Use of IV therapies or oral antibiotics for PLDS was associated with increased patient morbidity within 90 days.
Single-atom heterogeneous catalysts based on distinct carbon nitride scaffolds
Authors: Chen Zupeng , Vorobyeva Evgeniya , Mitchell Sharon , Fako Edvin , López Núria , Collins Sean M , Leary Rowan K , Midgley Paul A , Hauert Roland , Pérez-Ramírez Javier 
Published: April 2018

Abstract
Carbon nitrides integrating macroheterocycles offer unique potential as hosts for stabilizing metal atoms due to their rich electronic structure. To date, only graphitic heptazine-based polymers have been studied. Here, we demonstrate that palladium atoms can be effectively isolated on other carbon nitride scaffolds including linear melem oligomers and poly(triazine/heptazine imides). Increased metal uptake was linked to the larger cavity size and the presence of chloride ions in the polyimide structures. Changing the host structure leads to significant variation in the average oxidation state of the metal, which can be tuned by exchange of the ionic species as evidenced by X-ray photoelectron spectroscopy and supported by density functional theory. Evaluation in the semi-hydrogenation of 2-methyl-3-butyn-2-ol reveals an inverse correlation between the activity and the degree of oxidation of palladium, with oligomers exhibiting the highest activity. These findings provide new mechanistic insights into the influence of the carbon nitride structure on metal stabilization.
The Efficacy of Intraoperative Neurophysiological Monitoring to Detect Postoperative Neurological Deficits in Transforaminal Lumbar Interbody Fusion Surgery
Authors: Kim Joung Heon , Lenina Svetlana , Mosley Grace , Meaike Joshua , Tran Benjamin , Kim Jun S , Cho Samuel K 
Published: April 2018

Abstract

BACKGROUND
Despite the extensive use of intraoperative neurophysiological monitoring (IONM) in spinal procedures, there is no standard guideline for what types of IONM tests should be monitored during lumbar procedures with instrumentation. Moreover, the efficacy of IONM during transforaminal lumbar interbody fusion (TLIF) surgery in detecting postoperative neurological deficits has not been well described.

OBJECTIVE
To analyze waveform changes from individual IONM tests (somatosensory evoked potentials [SSEP], motor evoked potentials [MEP], and electromyography [EMG]) during TLIF and compare the sensitivity and specificity of these tests in order to determine the best combination to detect postoperative neurological deficits.

METHODS
Two hundred seventy-five consecutive TLIF cases with IONM between 2010 and 2014 were reviewed, and new postoperative sensory and motor deficits were documented. Sensitivity and specificity for each IONM test in detecting postoperative sensory and/or motor deficits were analyzed.

RESULTS
SSEP and EMG tests were performed on all 275 patients with 66 patients undergoing additional MEP tests. A total of 7 postoperative deficits have been reported: 2 sensory and 5 motor deficits. MEP test had high sensitivity (80.0%) and specificity (100%) in detecting motor deficits. However, SSEP changes failed to detect sensory deficits and EMG test had high false-positive rates for detecting both sensory (100%) and motor deficits (97.3%).

CONCLUSION
MEP test should be incorporated in monitoring protocols during spinal procedures that involve instrumentations below vertebral level L1 such as TLIF, as it provides high sensitivity and specificity in detecting postoperative motor deficits. In addition, we propose modifying the standard lower extremity SSEP monitoring protocol to correspond to the vertebral levels being operated on.
Comparison of warm season and cool season forages for dairy grazing systems in continuous culture1
Authors: Ruh Kathryn E , Heins Bradley J , Salfer Isaac J , Gardner Robert D , Stern Marshall D 
Published: April 2018

AbstractThe objective of this study was to compare warm-season annual grasses to cool-season perennial (CSP) grasses for ruminal nutrient digestibility and N metabolism in a dual-flow continuous culture fermentation system. Dietary treatments were 1) fresh alfalfa, 2) CSP grasses and legumes, 3) brown-midrib sorghum-sudangrass (BMRSS), and 4) teff grass from an organic dairy production system. Eight dual-flow continuous culture fermenters were used during two consecutive 10-d periods consisting of 7 d for stabilization followed by 3 d of sampling. Fermenter samples were collected on days 8, 9, and 10 for analysis of pH, NH3-N, and VFA. Apparent DM, OM, NDF, and ADF digestibility were on average lesser (P &lt; 0.05) in CSP grasses and legumes and warm-season annual grasses compared with alfalfa. True DM and OM digestibility were lesser (P &lt; 0.05) for CSP grasses and legumes and warm-season annual grasses compared with fresh alfalfa. Total VFA were not affected (P &gt; 0.05) by forage. The NH3-N concentrations were highest (P &lt; 0.05) with alfalfa compared with the other CSP grasses and legumes and warm-season annual grasses. CP digestibility was not affected (P &gt; 0.05) by forage treatment. Flow of NH3-N was greatest (P &lt; 0.05) for alfalfa, reflecting the greatest NH3-N concentration. Flow of total N was greatest (P &lt; 0.05) for alfalfa, intermediate for teff, and lowest for CSP grasses and legumes and BMRSS. Flows of bacterial N, efficiency of bacterial N, non-NH3-N, and dietary N were not affected (P &gt; 0.05) by forage source. Overall, fermentation of warm-season grasses was similar to the cool-season grasses and legumes which indicate dairy producers may use warm-season grasses without concerns about negative impact on rumen health.
Safety and Immunogenicity of Seven Dosing Regimens of the Candidate RTS,S/AS01E Malaria Vaccine Integrated Within an Expanded Program on Immunization Regimen
Authors: Witte Desiree , Cunliffe Nigel A. , Turner Ann M. , Ngulube Edward , Ofori-Anyinam Opokua , Vekemans Johan , Chimpeni Philips , Lievens Marc , Wilson Trevor P. , Njiram’madzi Jenala , Mendoza Yolanda Guerra , Leach Amanda 
Published: April 2018

Background:
In a phase III trial, the RTS,S/AS01 malaria vaccine produced lower anti-circumsporozoite (CS) antibody titers when co-administered with Expanded Programme on Immunization vaccines (0-, 1- and 2-month schedule) at 6 to 12 weeks compared with 5 to 17 months at first vaccination. Alternative infant immunization schedules within the Expanded Programme on Immunization were investigated.

Methods:
This phase II, open, single-site (Blantyre, Malawi) trial was conducted in infants 1 to 7 days of age. Subjects were equally randomized across 7 groups to receive 3 doses of RTS,S/AS01E at time points that included ≤7 days, 6, 10, 14 and 26 weeks, and 9 months. All RTS,S/AS01E groups plus a control group (without RTS,S/AS01E) received Bacillus Calmette-Guérin + oral poliovirus vaccine at ≤7 days, diphtheria, tetanus, whole-cell pertussis, hepatitis B and Haemophilus influenzae type b vaccine + oral poliovirus vaccine at 6, 10, and 14 weeks and measles vaccine at 9 months; one RTS,S/AS01E group and the control additionally received hepatitis B vaccination at ≤7 days. Serum anti-CS antibody geometric mean concentration (GMC; enzyme-linked immunosorbent assay) and safety were assessed up to age 18 months.

Results:
Of the 480 infants enrolled, 391 completed the study. No causally related serious adverse event was reported. A higher frequency of fever within 7 days of RTS,S/AS01E vaccination compared with control was observed. Compared with the standard 6-, 10-, 14-week schedule, anti-CS antibody GMC ratios post-dose 3 were significantly higher in the 10-, 14- and 26-week group only (ratio 1.80; 95% confidence interval, 1.24–2.60); RTS,S/AS01E vaccination at ≤7 days and 10 and 14 weeks produced significantly lower anti-CS GMCs (ratio 0.59; 95% confidence interval, 0.38–0.92).

Conclusions:
Initiation of RTS,S/AS01E vaccination above 6 weeks of age tended to improve anti-CS antibody responses. Neonatal vaccination was well tolerated but produced a comparatively lower immune response.
Utility relocation management in highway projects
Authors: Vilventhan Aneetha , Kalidindi Satyanarayana N. 
Published: April 2018

Purpose
Utility relocation issues are unfortunately frequent and recurring problems in several countries’ highway projects. Very few studies have addressed the utility relocation issues in highway projects. The purpose of this paper is two-fold. First, this paper explores how the utility relocation issues are managed in highway projects. Second, this paper systematically identifies the prioritized technical and coordination strategies to be adopted to avoid delays in utility relocation.

Design/methodology/approach
Multiple case-based research methodology was used to explore how the utility relocation issues are managed in highway projects. Empirical evidences from 11 road and bridge projects in India were used to develop the descriptive storyline for each of the project. The strategies used to manage the utility relocation issues were identified from three sources namely literature review, case studies and nominal group technique (NGT). The strategies were then evaluated quantitatively using NGT.

Findings
The analysis of the case studies showed that the delays in utility relocation were in the range of 5-52 months. It was found that the duration of relocation of utilities is impacted more significantly by the complexity of underground utilities rather than the size of the projects. Strategies that are used to manage utility relocation were identified across two groups namely; technical and coordination strategies.

Practical implications
Recommendations are provided for the practical use and policy changes.

Originality/value
The prioritized technical and coordination strategies can be used systematically to avoid delays in utility relocation.
The influence of personal characteristics on quantity surveyors’ job satisfaction
Authors: Lian Jonathan K.M. , Ling Florence Y.Y. 
Published: April 2018

PurposeThe purpose of this paper is to investigate the job satisfaction level of quantity surveyors (QSs); identify the personal characteristics that influence their job satisfaction; and provide recommendations to employers on how to enhance job satisfaction of QSs with different personal characteristics.Design/methodology/approachData were collected via a self-administered questionnaire to QSs in Singapore.FindingsQSs feel that they have significantly high passion for the job, are significantly satisfied with task variety and are treated fairly. However, they are significantly dissatisfied with their workload, hours worked, and lack of work-life balance. QSs in upper management have significantly higher job passion. Those in mid-management are more dissatisfied with their income. QSs who are married/attached, older, and more experienced are significantly more dissatisfied with their workload and hours worked than singles, younger, and less experienced QSs.Research limitations/implicationsSome dimensions of job satisfaction were not measured. Non-personal characteristics such as type of projects handled and type of clients were not investigated.Practical implicationsEmployers should investigate what goes into QSs’ workload, and weed out those that are of low value and unproductive in order to reduce their workload and hours worked, and thereby increase their job satisfaction.Social implicationsThe study contributes to human resource management by identifying the type of QSs who are more likely to be dissatisfied with their jobs.Originality/valueThis study shows that personal differences of QSs affect different dimensions of their job satisfaction. To maximize job satisfaction, employers could choose QSs who have specific characteristics, make changes to the work environment or redesign their jobs.
Authoritarian leadership supervisor support and workers’ compulsory citizenship behavior
Authors: Shu Chin-Yi , Chiang Yun-Haw , Lu Ching-Hua 
Published: April 2018

PurposeDrawing on uncertainty management theory, the purpose of this paper is to propose that experiencing the authoritarian leadership (AL) will weaken followers’ self-efficacy, which induces their compulsory citizenship behaviors (CCBs), defined as workers’ unwilling prosocial behaviors in helping colleagues.Design/methodology/approachSurvey/regression: data collected from Taiwanese workers supports the proposal.FindingsThe results not only support the proposal but also show that supervisor support will exacerbate the negative effect of AL with workers’ self-efficacy. Further, workers’ political skill will attenuate the above relationship.Originality/valueThis study complements scholarly knowledge about how AL, supervisor support, and political skill together influence workers’ self-efficacy, which then induces CCBs. The findings also remind supervisors not to offer support while at the same time demonstrating an AL style.
Post-war tourism as an urban reconstruction strategy case study: Khorramshahr
Authors: Mirisaee Seyed Mehdi , Ahmad Yahaya 
Published: April 2018

Purpose
Tourism development has been perceived as a promoter of city restoration and can also affect the post-war city reconstruction. Questions on how to reconstruct ruined buildings and urban areas through a post-war tourism-oriented approach based on the expectations of residents and tourists profound answers. The purpose of this paper is to adopt the sequential mixed method (qualitative and quantitative) with purposive sampling which is a non-probability method to investigate tourism-oriented approaches in the reconstruction of buildings and landmarks as the core components of urban tourism.

Design/methodology/approach
The study adopted the sequential mixed method (qualitative and quantitative) to investigate tourism-oriented approaches in the reconstruction of buildings and landmarks as the core components of urban tourism.

Findings
The findings of the study point that the preferred strategy for the reconstruction of damaged symbolic building is the preservation of the war effects in regard maintaining the buildings’ history to be considered by urban policy makers, urban designers, and authorities.

Research limitations/implications
The constraint was associated with the time-consuming nature of this type of research. Original documents of the research context and all the interview data were in the Persian language, making the translating process a time-consuming matter. Furthermore, data collection in the area located near the Iran-Iraq border (500 meters) presented a number of security caveats as limitations.

Originality/value
The research found a majority of tourists and the residents preferred tourism zone where the combination of post-war and natural attraction across riverside area. In other word, most considerable post-war attractions are those that combined with the appeal of the other tourism potentials like eco-leisure tourism. The preferred strategy for the reconstruction of damaged building reconstruction as post-war tourism attractions is the preservation of the war effects in regard maintaining the buildings history rather than reconstruction as the most likely to pre-war conditions with less attention paid to the war effects.
Multi-period dual-sourcing replenishment problem with option contracts and a spot market
Authors: Wan Nana , Chen Xu 
Published: April 2018

Purpose
The spot market has been gradually recognized as an important alternative purchasing source. To maintain a flexible replenishment strategy, call, put and bidirectional option contracts, as a risk hedging, are in combined usage with the spot market, respectively. The purpose of this paper is to analyze a finite-horizon replenishment problem with option contracts in the context of a spot market.

Design/methodology/approach
Based on stochastic dynamic programming, the firm’s optimal replenishment policy with either call, put or bidirectional option contracts is always shown to be order-up-to type, characterized by an upper threshold and a lower one. The corresponding policy parameters in different cases are calculated through an approximate algorithm. This research highlights the effectiveness of option contracts on the firm’s operational strategies and overall profitability.

Findings
This study reveals that the firm is better off with option contracts than without them. When the price parameters are the same for different option contracts, bidirectional option contracts are the best choice among these flexible contracts; otherwise, unilateral option contracts might be either better or worse than bidirectional ones. In addition, if low inventory costs and high spot price volatility are confronted, the firm prefers to call option contracts rather than put ones; otherwise, there exists an opposite conclusion.

Originality/value
In addition to highlight the advantage of option contracts over wholesale price contracts, this paper provides interesting observations with respect to the effect of different option contracts on the firm. Many significant insights derived from this research do not only contribute to the provider’s feasible design of the supply contracts, but also contribute to the user’s rational operational strategies for higher profitability.
Modelling online user behavior for medical knowledge learning
Authors: Li Daifeng , Madden Andrew , Liu Chaochun , Ding Ying , Qian Liwei , Zhou Enguo 
Published: April 2018

Purpose
Internet technology allows millions of people to find high quality medical resources online, with the result that personal healthcare and medical services have become one of the fastest growing markets in China. Data relating to healthcare search behavior may provide insights that could lead to better provision of healthcare services. However, discrepancies often arise between terminologies derived from professional medical domain knowledge and the more colloquial terms that users adopt when searching for information about ailments. This can make it difficult to match healthcare queries with doctors’ keywords in online medical searches. The paper aims to discuss these issues.

Design/methodology/approach
To help address this problem, the authors propose a transfer learning using latent factor graph (TLLFG), which can learn the descriptions of ailments used in internet searches and match them to the most appropriate formal medical keywords.

Findings
Experiments show that the TLLFG outperforms competing algorithms in incorporating both medical domain knowledge and patient-doctor Q&A data from online services into a unified latent layer capable of bridging the gap between lay enquiries and professionally expressed information sources, and make more accurate analysis of online users’ symptom descriptions. The authors conclude with a brief discussion of some of the ways in which the model may support online applications and connect offline medical services.

Practical implications
The authors used an online medical searching application to verify the proposed model. The model can bridge users’ long-tailed description with doctors’ formal medical keywords. Online experiments show that TLLFG can significantly improve the searching experience of both users and medical service providers compared with traditional machine learning methods. The research provides a helpful example of the use of domain knowledge to optimize searching or recommendation experiences.

Originality/value
The authors use transfer learning to map online users’ long-tail queries onto medical domain knowledge, significantly improving the relevance of queries and keywords in a search system reliant on sponsored links.
Examining the key determinants towards online pro-brand and anti-brand community citizenship behaviours
Authors: Wong T.C. , Haddoud Mohamed Yacine , Kwok Y.K. , He Hongwei 
Published: April 2018

Purpose
The purpose of this paper is to propose a research model to identify the key determinants and examine their impact towards online pro-brand and anti-brand community citizenship behaviours (CCBs).

Design/methodology/approach
A survey based on the research model is used to collect empirical data from 260 and 200 members of online pro-brand communities (OBCs) and online anti-brand communities (OABCs), respectively. A two-stage approach employing fuzzy-set qualitative comparative analysis and artificial neural network (ANN) is first applied to uncover new observations.

Findings
Moral identity and positive brand emotion (BE) are the two most influential factors driving both online pro-brand and anti-brand CCBs. A higher level of internalisation might be required to exhibit online anti-brand CCB as opposed to online pro-brand CCB. This contradicts the current understanding that anti-brand behaviours are less morally restricted given the virtuality and anonymity of online communities. OABC members may need to better justify themselves internally to overcome positive BE when exercising anti-brand action. Also, brand identification, brand dis-identification and BE would be used to identify two types of OABC members.

Research limitations/implications
The effect of motives other than pro-social remains unclear on online pro-brand and anti-brand CCBs.

Originality/value
This is the first paper to develop two new dimensions which provide a more complete definition of CCB. Also, some new observations are uncovered by comparing the effect of different key determinants on online pro-brand CCB against that of online anti-brand CCB. The research model can be used to define and improve member (or brand) engagement which would enhance the management of OBCs and OABCs.