bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamic abnormalities during muscle metaboreflex activation in patients with type 2 diabetes mellitus
Authors: Roberto Silvana , Milia Raffaele , Doneddu Azzurra , Pinna Virginia , Palazzolo Girolamo , Serra Stefano , Orrù Andrea , Hosseini Kakhak Seyed Alireza , Ghiani Giovanna , Mulliri Gabriele , Pagliaro Pasquale , Crisafulli Antonio 
Published: December 2018

Metaboreflex is a reflex triggered during exercise or postexercise muscle ischemia (PEMI) by metaboreceptor stimulation. Typical features of metaboreflex are increased cardiac output (CO) and blood pressure. Patients suffering from metabolic syndrome display hemodynamic abnormalities, with an exaggerated systemic vascular resistance (SVR) and reduced CO response during PEMI-induced metaboreflex. Whether patients with type 2 diabetes mellitus (DM2) have similar hemodynamic abnormalities is unknown. Here we contrast the hemodynamic response to PEMI in 14 patients suffering from DM2 (age 62.7 ± 8.3 yr) and in 15 age-matched controls (CTLs). All participants underwent a control exercise recovery reference test and a PEMI test to obtain the metaboreflex response. Central hemodynamics were evaluated by unbiased operator-independent impedance cardiography. Although the blood pressure response to PEMI was not significantly different between the groups, we found that the SVR and CO responses were reversed in patients with DM2 as compared with the CTLs (SVR: 392.5 ± 549.6 and −14.8 ± 258.9 dyn·s−1·cm−5; CO: −0.25 ± 0.63 and 0.46 ± 0.50 l/m, respectively, in DM2 and in CTL groups, respectively; P < 0.05 for both). Of note, stroke volume (SV) increased during PEMI in the CTL group only. Failure to increase SV and CO was the consequence of reduced venous return, impaired cardiac performance, and augmented afterload in patients with DM2. We conclude that patients with DM2 have an exaggerated vasoconstriction in response to metaboreflex activation not accompanied by a concomitant increase in heart performance. Therefore, in these patients, blood pressure response to the metaboreflex relies more on SVR increases rather than on increases in SV and CO. NEW & NOTEWORTHY The main new finding of the present investigation is that subjects with type 2 diabetes mellitus have an exaggerated vasoconstriction in response to metaboreflex activation. In these patients, blood pressure response to the metaboreflex relies more on systemic vascular resistance than on cardiac output increments.
Facility-Level Variation and Clinical Outcomes in Use of Cardiac Resynchronization Therapy With and Without an Implantable Cardioverter-Defibrillator
Authors: Kramer Daniel B. , Normand Sharon-Lise T. , Volya Rita , Hatfield Laura A. 
Published: December 2018

Background:
Little is known about real-world facility-level preferences for cardiac resynchronization therapy devices with (CRT-D) and without (CRT-P) defibrillator backup. We quantify this variation at the facility level and exploit this variation to compare outcomes of patients receiving these 2 devices.

Methods and Results:
Claims data from fee-for-service Medicare beneficiaries were used to identify new CRT-P and CRT-D implants, 2006 to 2012. We modeled factors associated with receipt of each device, and compared mortality, hospitalizations, and reoperations for patients receiving each using both logistic regression and instrumental variable analysis to account for confounding. Among 71 459 device recipients (CRT-P, 11 925; CRT-D, 59 534; 31% women), CRT-P recipients were older, more likely to be women, and had more comorbidities. Variation in device selection among facilities was substantial: After adjustment for patient characteristics, the odds of receiving a CRT-P (versus CRT-D) device were 7.6× higher for a patient treated at a facility in the highest CRT-P use quartile versus a facility in the lowest CRT-P use quartile. Logistic modeling suggested a survival advantage for CRT-D devices but with falsification end points indicating residual confounding. By contrast, in the instrumental variable analysis using facility variability as the proposed instrument, clinical characteristics and falsification end points were well balanced, and 1-year mortality in patients who received CRT-P versus CRT-D implants did not differ, while CRT-P patients had a lower probability of hospitalizations and reoperations in the year following implant.

Conclusions:
CRT-P versus CRT-D selection varies substantially among facilities, adjusted for clinical factors. After instrumental variable adjustment for clinical covariates and facility preference, survival was no different between the devices. Therefore, CRT-P may be preferred for Medicare beneficiaries considering new CRT implantation.
Trissolcus radjabii n.sp. (Hymenoptera: Platygastridae), an egg parasitoid of the shield bug, Apodiphus amygdali (Heteroptera: Pentatomidae) and the sunn pest, Eurygaster integriceps (Heteroptera: Scutelleridae)
Authors: IRANIPOUR SHAHZAD , JOHNSON NORMAN F. 
Published: December 2018

Kozlov and Kononova (1983) classified 53 Palearctic species of the genus Trissolcus Ashmead into five groups. The presence of the hyperoccipital carina, convex frons, absence of notauli, and elongate postmarginal vein (longer than the stigmal vein) in the fore wing are characteristics delimiting the gonopsidis-group. These species differ from the flavipes-group only in the lack of notauli. Kozlov and Kononova placed three species in the gonopsidis-group: T. mentha Kozlov and Lê, T. gonopsidis (Watanabe), and T. elasmuchae (Watanabe). In a taxonomic study of the Trissolcus species of Korea and Japan, Ryu and Hirashima (1984) reported three other species with characteristics of the gonopsidis-group: T. nigripedius (Nakagawa), T. itoi Ryu and T. yamagishi Ryu. Most of these species are known only from Japan or Korea. Trissolcus elasmuchae has been observed in Ukraine and Russia as well as Japan, and T. mentha is known only from Uzbekistan. Trissolcus antakyaensis Doganlar was described recently as an egg parasitoid of the pentatomid Rhaphigaster nebulosa (Poda) from Turkey (Doganlar 2001). It, too, fits within this gonopsidis- group. The New World species of Trissolcus were divided into three groups (Johnson 1984, 1985a, 1985b); the thyantae, basalis, and flavipes groups of Johnson are roughly equivalent to the simoni, semistriatus, and flavipes groups of Kozlov and Kononova respectively. No species of gonopsidis and oobius groups of Kozlov and Kononova have been reported in New World fauna.
Estimation of the Variability of Mesoscale Energy Spectra with Three Years of COSMO-DE Analyses
Authors: Selz Tobias , Bierdel Lotte , Craig George C. 
Published: December 2018

Abstract
Research on the mesoscale kinetic energy spectrum over the past few decades has focused on finding a dynamical mechanism that gives rise to a universal spectral slope. Here we investigate the variability of the spectrum using 3 years of kilometer-resolution analyses from COSMO configured for Germany (COSMO-DE). It is shown that the mesoscale kinetic energy spectrum is highly variable in time but that a minimum in variability is found on scales around 100 km. The high variability found on the small-scale end of the spectrum (around 10 km) is positively correlated with the precipitation rate where convection is a strong source of variance. On the other hand, variability on the large-scale end (around 1000 km) is correlated with the potential vorticity, as expected for geostrophically balanced flows. Accordingly, precipitation at small scales is more highly correlated with divergent kinetic energy, and potential vorticity at large scales is more highly correlated with rotational kinetic energy. The presented findings suggest that the spectral slope and amplitude on the mesoscale range are governed by an ever-changing combination of the upscale and downscale impacts of these large- and small-scale dynamical processes rather than by a universal, intrinsically mesoscale dynamical mechanism.
How Long Does a 15-Year Drought Last? On the Correlation of Rare Events
Authors: Rhee George , Salazar Jimmy , Grigg Corwin 
Published: December 2018

Abstract
Communities reliant upon the Colorado River system are at risk of water shortages because of fluctuations of the river’s streamflows. The solution to the water supply problem for the Colorado River system lies within a quantitative understanding of these fluctuations during droughts. Streamflow data (direct and inferred) for the Colorado River extend back approximately 1200 years through the analysis of tree-ring records (Meko et al.; Woodhouse et al.). We further analyze these data using a mathematical model to present estimates for the future water supply of the Colorado River by comparing measured streamflows of the past century with the yearly tree-ring data of the Colorado River. We estimate that the Colorado River system’s reservoirs lack enough stored water reserves to last through the current drought, which has been ongoing since 2000. If true, it is essential to reevaluate the way water is used and stored for the Colorado River. The methods presented are relevant to any river system whose streamflow statistics are Gaussian.
A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis: a randomized controlled trial with 2 year follow-up
Authors: Centeno Christopher , Sheinkop Mitchell , Dodson Ehren , Stemper Ian , Williams Christopher , Hyzy Matthew , Ichim Thomas , Freeman Michael 
Published: December 2018

AbstractBackgroundCell-based therapies have shown promise for the treatment of knee osteoarthritis (OA). The current study compared exercise therapy to autologous bone marrow concentrate (BMC) and platelet products for knee OA treatment.MethodsPatients with symptomatic knee OA (N = 48) were randomized into either an exercise therapy control group or treatment group with injection of autologous BMC and platelet products. Patients in the control group could crossover to BMC treatment after 3 months. Clinical outcomes were documented at baseline and at 6-weeks, 3, 6, 12 and 24 months, including the Knee Society Score (KSS), Pain Visual Analogue Scale, Short Form-12 Scales (SF-12), and Lower Extremity Activity Scale (LEAS).ResultsAll patients in the exercise group crossed over to receive BMC treatment after 3 months (N = 22 crossover). At 3 months, KSS-knee, SF-12 Physical, and LEAS improved significantly in the crossover group compared to exercise, similar to significant improvements on KSS-knee and LEAS for the treatment group (N = 26) compared to exercise group at 3 months. After BMC treatment, patients’ clinical outcome scores (except SF-12 Mental Health), were significantly improved through the 2-year follow-up compared to baseline. No serious adverse events were reported.ConclusionThe use of image-guided percutaneous BMC with platelet products yielded better results than exercise therapy as an effective alternative therapy for patients with symptomatic moderate to moderate-severe osteoarthritis of the knee.Trial registrationNCT02034032.https://clinicaltrials.gov/ct2/show/NCT02034032. Registered 13 January 2014
Vivências de idosas alcoolistas: contribuições para a enfermagem gerontológica
Authors: Viegas Rejane de Fátima Parada , Siqueira Janaina Moreno de , Donato Marilurde , Mauro Maria Yvone Chaves , Farias Sheila Nascimento Pereira de , Silva Beatriz Gomes da 
Published: December 2018

Objetivo: identificar as causas do uso abusivo de bebidas alcoólicas por idosos. Método: pesquisa qualitativa, utilizou-se o método história de vida para relatar vivência de idosos alcoolista. A amostra foi composta de 22 idosos, a coleta de dados foi realizada em 2007 e 2008, em um albergue público de Campo Grande e três grupos de AA de Jacarepaguá, todos em bairros do Rio de Janeiro. O projeto foi aprovado por Comitê de Ética em Pesquisa. As entrevistas foram gravadas em mp3 e na análise de dados, procedeu-se a transcrição das gravações dos depoimentos. Resultados: dos depoimentos emergiram a categoria – os bastidores do alcoolismo na velhice e as subcategorias – a família como causa primária e a influência social. Conclusão: é necessário implementar política de educação e de saúde para prevenção, tratamento e reabilitação do alcoolismo, também entre idosos, visando à redução de danos e melhor qualidade de vida.
Cofilin-1 as a potential biomarker to evaluate acute kidney injury
Authors: Coşkun Abdurrahman , Ucal Yasemin , Berber Ibrahim , Çakır Ülkem , Serteser Mustafa , Moldur Derya Emel , İzzete Derelioğlu Ecenur , Yozgatlı Tahir Koray , Özpınar Aysel , Ünsal İbrahim 
Published: December 2018

Abstract
Acute kidney injury (AKI) is a worldwide health problem and defined by rapid loss of excretory function of the kidney with the accumulation of metabolic end products. For effective treatment and prevent complications the early diagnosis of AKI is crucial. The current analytes used to diagnose AKI are not adequately sensitive and specific and therefore clinicians need new biomarkers. One of the new promising biomarker candidates of renal injury is cofilin-1. Previously, in our laboratory we isolated cofilin-1 in kidney preservation solution prior to transplantation and attempted to measure serum cofilin-1 in renal transplanted patients. However, cofilin-1 was not accurately measured in serum samples due to the methodological issues. In this mini-review, we summarized the current knowledge and concepts both in the literature and our experiences with cofilin-1 as a potential biomarker for the diagnosis and management of AKI.
Development and Application of a Multifunction True Triaxial Rock Drilling Test System
Authors: Wang Qi , Gao Hongke , Jiang Bei , Li Shucai , Gao Song , He Manchao , Zhang Chong 
Published: December 2018

Abstract
The real-time acquisition of the rock mass mechanical parameters and the rapid classification of the surrounding rock during the construction of an underground structure are of great value for informational construction and optimization of the parameters of the supporting structure. However, it is currently difficult to rapidly acquire rock mass mechanical parameters at construction sites. The “digital drilling rig”–based drilling test technique is an effective approach for addressing this problem. Therefore, this study develops a multifunction true triaxial rock-drilling test system (TRD system). This system can be employed to test various types of rock or fractured rock masses to determine the correlations between the drilling parameters and the rock mechanical parameters under three-dimensional confining pressure conditions. This article introduces the basic features and the composition of each component of the TRD system. Drilling tests on different types of rock specimens under various control parameter conditions are performed, and the drilling tests on sandstone specimens under different confining pressures were carried out. The test results demonstrate significant correlations between the drilling parameters and between the drilling parameters and the rock mechanical parameters during the drilling process. The drilling parameters are responsive to confining pressure. The conclusions of the correlation analysis and the stable monitoring data obtained under various test parameter conditions verify the reasonableness and effectiveness of the TRD system’s structure. This study lays the foundation for further investigations of the quantitative relationships between the drilling parameters and the rock mechanical parameters and develops a key technology that uses the drilling parameters of a “digital drilling rig” to characterize the mechanical parameters of the surrounding rock at underground construction sites.
Development and Application of a Performance Evaluation Matrix: A Case Study on Exploring the Items Considered Critical to Quality
Authors: Chen Kuen-Suan , Lii Peir-Chyi , Li Shao-Yu , Yu Chun-Min 
Published: December 2018

Abstract
A performance evaluation matrix is based on questionnaires collected from users or customers to pinpoint the performance of a system operation and furthermore to locate the items that need to be improved to upgrade the performance of system operations. To achieve this, this article proposes a discrimination index and applies statistics inference to deduce confidence intervals of the discrimination index. Meanwhile, we refer to Buckley’s fuzzy testing method to construct a fuzzy affiliation function and address a fuzzy evaluation criterion for exploring the items considered critical to quality to overcome the complicated problems of the questionnaires’ sampling error and interviewees’ fuzzy linguistics. The advantages of the method in this article are that it keeps the simple filling pattern of Likert’s scale and provides efficacy of data collection. Subsequently, we reduce the fuzzy linguistics and questionnaires’ sampling error by statistics inference and fuzzy hypothesis testing. Finally, we use a case study with the computer-assisted language learning system to demonstrate an application of the proposed method.
Determining the Genetic Architecture of Reproductive Stage Drought Tolerance in Wheat Using a Correlated Trait and Correlated Marker Effect Model
Authors: Dolferus Rudy , Thavamanikumar Saravanan , Sangma Harriet , Kleven Sue , Wallace Xiaomei , Forrest Kerrie , Rebetzke Gregory , Hayden Matthew , Borg Lauren , Smith Alison , Cullis Brian 
Published: December 2018

Abstract
Water stress during reproductive growth is a major yield constraint for wheat (Triticum aestivum L). We previously established a controlled environment drought tolerance phenotyping method targeting the young microspore stage of pollen development. This method eliminates stress avoidance based on flowering time. We substituted soil drought treatments by a reproducible osmotic stress treatment using hydroponics and NaCl as osmolyte. Salt exclusion in hexaploid wheat avoids salt toxicity, causing osmotic stress. A Cranbrook x Halberd doubled haploid (DH) population was phenotyped by scoring spike grain numbers of unstressed (SGNCon) and osmotically stressed (SGNTrt) plants. Grain number data were analyzed using a linear mixed model (LMM) that included genetic correlations between the SGNCon and SGNTrt traits. Viewing this as a genetic regression of SGNTrt on SGNCon allowed derivation of a stress tolerance trait (SGNTol). Importantly, and by definition of the trait, the genetic effects for SGNTol are statistically independent of those for SGNCon. Thus they represent non-pleiotropic effects associated with the stress treatment that are independent of the control treatment. QTL mapping was conducted using a whole genome approach in which the LMM included all traits and all markers simultaneously. The marker effects within chromosomes were assumed to follow a spatial correlation model. This resulted in smooth marker profiles that could be used to identify positions of putative QTL. The most influential QTL were located on chromosome 5A for SGNTol (126cM; contributed by Halberd), 5A for SGNCon (141cM; Cranbrook) and 2A for SGNTrt (116cM; Cranbrook). Sensitive and tolerant population tail lines all showed matching soil drought tolerance phenotypes, confirming that osmotic stress is a valid surrogate screening method.
How to counter the ten myths about work addiction?: Three postulates for future research
Authors: Malinowska Diana 
Published: December 2018

Background and aimReferring toTen myths about work addictionreviewed by Griffiths, Demetrovics, and Atroszko in theJournal of Behavioral Addiction, three postulates were proposed to apply in future research on work addiction: (a) the clinical psychology perspective, (b) the systems approach, and (c) diversified and adequate methodologies.MethodsIn a narrative review, using theoretical assumptions and empirical data, postulates were discussed against myths.ResultsThe opportunities offered by the perspectives and new insights related to myths were presented.ConclusionIt appears that the three postulates may contribute to theoretical and methodological progress in future research on work addiction.
O ENSINO PERSONALIZADO: ALGUMAS INVESTIGAÇÕES
Authors: Santos Rodrigo Otávio dos , Silva Roberta Galon 
Published: December 2018

O presente trabalho visa apresentar o ensino personalizado – também chamado adaptativo –, seus métodos, técnicas e sistemas. Com este artigo pretendemos dar nossa contribuição para o avanço na pesquisa desta área que muito se destaca no ambiente corporativo, mas ainda carece de pesquisas acadêmicas mais aprofundadas. O meio educacional ainda necessita de mais trabalhos que se distanciem da mera adaptação de técnicas utilizadas por empresas cujo mote principal é apenas o lucro. Neste texto discutimos a taxonomia, os métodos específicos utilizados pelos softwares que se dispõem a esta finalidade, as técnicas de apresentação adaptativa do conteúdo e suas variáveis, as formas de navegação desenvolvidas especificamente para este tipo de conteúdo, a função do contexto e sua utilização relativa às formas pretendidas de personalização, os diferentes tipos de aprendizagem e sua relação com a metacognição. A metodologia que utilizamos para este trabalho foi a de revisão bibliográfica, abarcando a discussão da literatura mais atual e abrangente no referido tema. Ao final do artigo procuramos fazer uma tabela com os diferentes tipos de alunos, seus estilos de aprendizagem e as diferentes atividades que podem ser direcionadas a eles.
Palavras-Chave: Ensino personalizado. Ensino adaptativo. Estilos de aprendizagem. Hipermídias adaptativas
EDUCAÇÃO DE JOVENS E ADULTOS E A EVASÃO ESCOLAR: ANÁLISE E PROPOSIÇÃO
Authors: Ostrovski Crizieli Silveira , Correia Zélia Delgado 
Published: December 2018

Este artigo é resultado da pesquisa que teve como objetivo abordar as causas da evasão escolar na modalidade de Educação de Jovens e Adultos, EJA. Analisam-se os dados estatísticos obtidos por meio das respostas do questionário aplicado como instrumento de coleta, apontam-se estratégias pedagógicas que podem ser aplicadas no ambiente escolar, visando a permanência do aluno neste programa de educação formal. A pesquisa foi direcionada aos alunos do Centro Estadual de Educação Básica para Jovens e Adultos- CEEBJA, escola localizada em uma cidade do interior o Paraná, matriculados no primeiro semestre de 2011. Os resultados mostram que, apesar das inúmeras causas que justificam o alto índice de evasão, há, por outro lado, grande interesse do aluno em concluir seu estudo formal. Então, considerando os dados compilados, para o profissional de educação que trabalha na modalidade de Educação de Jovens e Adultos, fica a “missão” de delinear novas ações, adaptar e rever antigas posturas, para melhorar o processo educativo no ambiente escolar e a consequente permanência do aluno na EJA.
Palavras-chave: Evasão Escolar. Situação Social. Educador. EJA.
A CRIANÇA E OS ESPAÇOS PÚBLICOS: REFLEXÕES ACERCA DAS IMPLICAÇÕES DA PARTICIPAÇÃO INFANTIL
Authors: Oliveira Fabiana de 
Published: December 2018

Este ensaio de natureza reflexiva tem como objetivo central discutir as mudanças ocorridas em relação à criança e à infância tendo como recorte a consideração da participação infantil enquanto uma grande transformação ocorrida nos modos de relação até então estabelecidos entre adultos e crianças, já que as crianças sempre foram uma categoria excluída socialmente. A partir disso apresentamos as seguintes questões norteadoras para esta reflexão: quais as possibilidades de participação infantil? Quais as mudanças necessárias na relação entre adultos e crianças para que estas possam participar de processos decisórios que as afetam? A presente reflexão buscará responder estes questionamentos que são centrais na discussão atual do campo teórico que concebe a criança como um ator social e sua participação nos vários âmbitos da sociedade, especificamente na organização dos espaços públicos. Entende-se que por meio dos Novos Estudos sobre a Infância, especialmente a partir da Sociologia da infância e de um Enfoque de Direitos, será possível pensar em formas de atuação das crianças na transformação da estrutura social.
Palavras-chave: Crianças. Direitos. Espaços públicos. Participação infantil