bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and prognostic significance of Hec1 expression in patients with Cervical Cancer
Authors: Zhao Yutai , Xu Lei , Peng Cong , Deng Jie , Huang Chaolin , Lu Ling 
Published: October 2024

ObjectiveHec1 is a component of the Ndc80 kinetochore complex and is frequently upregulated in various cancers. However, the clinical significance of Hec1 in cervical cancer remains largely unknown. This study aimed to investigate the expression patterns of Hec1 in cervical cancer and its relationship with the clinicopathological characteristics of patients diagnosed with the disease.MethodsImmunohistochemistry was used to assess the expression of Hec1 in 136 cervical cancer tissue samples and 82 normal cervical tissue samples. The relationship between Hec1 protein expression and the clinicopathological characteristics of cervical cancer patients was analyzed using the Chi-square test. Additionally, the association between Hec1 protein expression and patient survival was examined using Kaplan-Meier survival curves. Independent risk factors affecting the prognosis of cervical cancer patients were analyzed using the Cox proportional hazards regression model.ResultsThe positive expression rate of Hec1 protein in cervical cancer tissues was 83.82%, significantly higher than the 7.31% in normal cervical tissues. Compared to patients with negative Hec1 expression, those with positive expression exhibited significantly higher FIGO staging, increased lymph node metastasis, greater depth of tumor stromal infiltration, and larger tumor diameter. Multivariable analysis using the Cox proportional hazards regression model indicated that Hec1 positive expression was an independent risk factor for both overall survival (HR = 2.79, 95% CI: 1.65–4.05, p = 0.012) and progression-free survival (HR = 1.81, 95% CI: 1.22-3.18, p = 0.002) in cervical cancer patients. Kaplan-Meier survival curve analysis showed that patients with positive Hec1 expression experienced a lower overall survival (HR: 2.72, 95% CI: 1.15–4.52, p = 0.004) and progression-free survival (HR: 3.12, 95% CI: 1.62–5.03, p = 0.002) when compared to those with negative Hec1 expression.ConclusionHec1 is significantly upregulated in cervical cancer tissues and associated with poor prognosis in cervical cancer patients. Therefore, Hec1 could be a novel biomarker, not only for the diagnosis and treatment evaluation of cervical cancer but also as an indicator for predicting the prognosis of cervical cancer patients.
Paraaortic lymph node metastasis in endometrial cancer patients: a comprehensive analysis of rates, survival outcomes, and risk factors through systematic review and meta-analysis
Authors: Han Ling , Chen Yali , Zheng Ai , Tan Xin , Chen Hengxi 
Published: October 2024

IntroductionThis study aims to explore the incidence of different metastatic patterns in paraaortic lymph nodes and their corresponding survival outcomes in patients with endometrial cancer, as well as to identify the associated risk factors of such metastasis.Material and methodsPubMed, Embase, Cochrane Central Register of Controlled Trials, International Clinical Trials Registry Platform, and Clinical Trials.gov were searched from inception to February 10, 2024.The analysis was conducted using R version 4.2.3.ResultsA total of 47 studies involving 33,425 endometrial cancer patients were analyzed. Meta-analysis results revealed that the rate of isolated paraaortic lymph node metastasis, where pelvic lymph nodes were negative but paraaortic lymph nodes were positive (PLN-PAN+), was found to be 2.58% (95% CI 0.0195-0.0329). The rates for PLN+PAN- and PLN+PAN+ were notably higher at 8.54% (95% CI 0.0642-0.1092) and 8.37% (95% CI 0.0613-0.1090), respectively. For clinical stage I EC, the occurrence rate was 5.92% for PLN+PAN- (95% CI 0.0258-0.1032), 1.00% for PLN-PAN+ (95% CI 0.0081-0.0120), and 2.99% for PLN+PAN+ (95% CI 0.0188-0.0431). The survival outcomes indicate a decreasing trend from the PLN-PAN+ and PLN+PAN- groups to the PLN+PAN+ group. Additionally, the survival outcomes of patients with isolated paraaortic lymph node metastasis appear to be comparable to, or not inferior to, those of the PLN+PAN- group. The analysis indicated that pelvic lymph node metastasis (OR 16.72, 95% CI 10.03-27.86), myometrial invasion ≥50% (OR 5.18, 95% CI 3.09-8.69), lymph-vascular space invasion (LVSI) (OR 3.46, 95% CI 2.49-4.81), cervical invasion (OR 4.00, 95% CI 2.09-7.66), and non-endometrioid cancer (OR 2.39, 95% CI 1.17-4.86) were risk factors for paraaortic lymph node metastasis.ConclusionsIsolated paraaortic lymph node metastasis, though relatively rare, can still occur even in clinical stage I endometrial cancer. The survival outcomes of patients with isolated paraaortic lymph node metastasis appear to be comparable to, or not inferior to, those of the PLN+PAN- group. Even in patients with negative pelvic lymph nodes, careful consideration should be given to the possibility of paraaortic lymph node metastasis, especially in those with high-risk factors.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024503959.
The effectiveness and factors influencing frequency of endoscopic bougie dilatation in treating postoperative anastomotic stenosis of congenital esophageal atresia
Authors: He Xiao-qing , Xiong Li-jing , Deng Xiao-zhi , Yang Zheng-bing , Yan Huan , Zhang Yi-xian , Shang Li-hong , Xie Xiao-li , Liu Li-rong , Li Jing 
Published: October 2024

ObjectiveThis study is to evaluate the effectiveness and frequency factors of endoscopic bougie dilatation in treating postoperative anastomotic stenosis of congenital esophageal atresia (CEA).MethodsThe clinical data of patients of anastomotic stenosis with endoscopic bougie were retrospectively analyzed. According to the number of dilation times (ND), patients were divided into two groups (Group 0: ND &lt; 3; Grooup1: ND ≥ 3), and the differences in multiple clinical data were compared. Lasso regression and Ridge regression were used to screen important variables. Classification models were built utilizing various machine learning algorithms and their performance were evaluated. Finally, Kaplan-Meier model was used to estimate the probable-time distribution of children achieving normal feeding.ResultsSeventy-five patients underwent a total of 210 times of dilation, with a median of 3 times of dilation. The overall effectiveness was 98.67% (74/75), with perforation in 2 case (0.95%), and obvious bleeding in 3 cases (1.43%). Initial diameter of bougie, final diameter of bougie, treatment pattern (Regular: dilation each 4weeks; Wait-and-see: dilation until symptoms present), age at final dilation, esophageal obstruction by food were the factors related to ND. Random Forest (RF) and Logistic regression (LR) model were excellent models for predicting ND. The median age for achieving normal eating in Group0 was 120 days (95% CI: 90–160), while it was 270 days (95% CI: 240–460) in Group1 with a statistically significant difference (P &lt; 0.0001).ConclusionEndoscopic bougie dilatation is a safe and effective treatment for anastomotic stenosis. Selecting the appropriate bougie, using symptoms as the criterion for dilation, and minimizing the dilations under 3 times constitute a rational strategy.
Protective effect of baicalin on oxidative stress injury in retinal ganglion cells through the JAK/STAT signaling pathway in vitro and in vivo
Authors: Yu Huan , Zhou Dan , Wang Wei , Wang Qingxia , Li Min , Ma Xiaoyun 
Published: October 2024

Background and PurposeThe damage or apoptosis of retinal ganglion cells (RGCs) is one of the leading causes of various blinding eye diseases, such as glaucoma, diabetic retinopathy, optic neuritis, and ischemic optic neuropathy. Oxidative stress is involved in RGCs death. Baicalin, a flavonoid compound extracted from Scutellaria baicalensis, has various beneficial effects, including anti-inflammatory, anti-apoptotic, and antioxidant properties. However, the effects of baicalin on RGCs and the underlying mechanisms require further investigation.MethodsIn this study, a glutamate-induced oxidative stress damage model of R28 cells and a rat retinal injury model were established to investigate the effects of baicalin on oxidative stress damage to RGCs and try to elucidate the underlying mechanism.ResultsIn vitro experiments demonstrated that the survival rate of R28 cells after glutamate treatment dropped to 33.4%, while 10 μM baicalin significantly inhibited glutamate-induced damage in RGCs (P &lt; 0.001) and enhanced cell viability through decreasing ROS levels, increasing antioxidant enzyme activity, and suppressing the expression of inflammatory factors iNOS, TNF-α, IL-6, and IL-1β (P &lt; 0.001). In vivo, baicalin effectively mitigated structural damage to retinal tissue and RGCs morphology induced by glutamate, increasing the thickness of the retinal ganglion cell layer, improving RGCs density, and reducing overall retinal thinning in rats (P &lt; 0.001) in a time- and dose-dependent effects. Mechanistic studies revealed that glutamate evaluated the phosphorylation levels of JAK/STAT, while baicalin effectively inhibited the activation of the JAK/STAT signaling pathway.ConclusionThis study confirmed that baicalin protects against glutamate-induced oxidative stress damage in RGCs. It effectively alleviates oxidative stress and inflammatory responses, reduces cell apoptosis, and improves the pathological changes in the retina of rat models of RGCs damage, thereby decreasing RGCs death. Further exploration of its mechanism revealed that baicalin effectively inhibits the JAK/STAT signaling pathway, protecting RGCs from oxidative stress damage. This provides an experimental basis for the application of baicalin in the treatment of RGCs damage.
Thematic and intertextual analysis from a feasibility study of the Bonny Method of Guided Imagery and Music with clients in eating disorder treatment
Authors: Heiderscheit Annie 
Published: October 2024

IntroductionEating disorders (ED) are characterized by serious and persistent disturbances with eating, weightcontrol, and body image. Symptoms impact physical health, psychosocial functioning, and can be life-threatening. Individuals diagnosed with an ED experience numerous medical and psychiatric comorbidities due to issues caused by or underlying the ED. Therefore, it is vital to address the complex nature of an ED, as well as the comorbid and underlying issues. This necessitates a psychotherapeutic approach that can help to uncover, explore, and support working through unresolved emotions and experiences. Guided Imagery and Music (GIM) is an in-depth music psychotherapy approach utilizing therapist-programmed music to support the client in uncovering and examining underlying and unresolved issues. The literature surrounding the use of GIM with clients in ED treatment is anecdotal and comprised primarily of clinical case studies.MethodThis secondary analysis, based on a descriptive feasibility study that integrated GIM sessions into the client’s regular ED treatment and examined 116 transcripts from a series of sessions of eight clients.ResultsThematic analysis of the transcripts identified nine subthemes and three themes that emerged. These themes include emotional landscape (feeling stuck, acknowledging emotions, and working through unresolved emotions), relationships (self, others, and eating disorders), and transformation and growth (finding strength, change, and empowerment). A short series of GIM sessions helped ED clients identify and address issues underlying the ED and to gain or reclaim a sense of self that enabled them to make choices for their life that support their recovery and sense of empowerment. Intertextual analysis revealed imagery indicative of the Hero’s Journey.DiscussionFurther, how engagement in this embodied aesthetic experience stimulates perceptual, cognitive, and affective brain functions which are key in fostering behavioural and psychological change is explicated as it relates to ED treatment and recovery.
Associations between family factors and physical activity clustering in preschool children: a cross-sectional study
Authors: Huang Ting , Zhao Guanggao , Fu Jinmei , Sun Shunli , Lv Wendi , He Zihao , Chen Delong , Chen Ruiming 
Published: October 2024

ObjectiveThis study aimed to examine the association between family factors and physical activity (PA) clustering in preschool children.MethodsPreschoolers’ PA and sedentary behavior (SB) were assessed consecutively for 7 days using ActiGraph accelerometers based on the cutoff counts developed by Pate et al. Information about children, their parents, and their families was collected using questionnaires. We developed a two-step approach to clustering PA both inside and outside of kindergarten. The Euclidean distance metric was utilized to distinguish between groups, while the Schwarz–Bayesian criterion was applied to identify the most optimal sub-group model. A one-way ANOVA was used to assess the clustering effect, and logistic regression was used to analyze the influencing factors of different clustering.ResultsWe collected data from 291 preschool children aged 3 to 6 years and divided them into three clusters—Inactive (50.2%), Active in kindergarten (26.8%), and Active outside kindergarten (23.0%)—with significant differences in PA and SB, revealing distinct temporal and spatial clustering patterns (silhouette coefficient = 0.3, p &lt; 0.05). Furthermore, preschooler activity levels correlated significantly with factors including gender (OR = 0.35, 95% CI: 0.19–0.66), age (OR = 1.05, 95% CI: 1.00–1.10), birth weight (OR = 1.79, 95% CI: 1.16–2.76), paternal age (OR = 1.01, 95% CI: 1.00–1.02), and maternal income (OR = 0.68, 95% CI: 0.48–0.96).ConclusionThis study shows that the family environment or parents significantly influence the PA of preschool children. Older fathers may promote preschool children’s PA through greater educational focus and financial stability, while higher maternal income can provide more opportunities and resources for preschool children to engage in active lifestyles. Thus, it is suggested that families providing more attention and exercise opportunities for preschool children’s education can help improve their PA levels in the future.
Dominion on Grids
Authors: Su Jianning , Allagan Julian , Gao Shanzhen , Malomo Olumide , Gao Weizheng , Eyob Ephrem 
Published: October 2024

The domination (number) of a graph G=(V,E), denoted by γ(G), is the size of the minimum dominating sets of V(G), also known as γ-sets. As such, the dominion of G, denoted by ζ(G), counts all its γ-sets. We proved a conjecture from one of the authors on the dominion of cycles C3k−1 and C3k−2, k≥2. Further, we found the formulae and recurrence relations for the dominions of several grids, Gm,n, with 2≤m≤4 and other results when m≤9 and n≤20. In general, domination and dominion play important roles in assessing certain vulnerabilities of any given network system.
БАЛАЛАРДАҒЫ ДӘНЕКЕР ТІННІҢ ДИСПЛАЗИЯ МӘСЕЛЕЛЕРІНІҢЕРЕКШЕЛІКТЕРІ: ӘДЕБИЕТТЕРДІШОЛУ
Authors: А.Ж. Абылгазинова , Т.Х. Рымбаева , М.Р. Мадиева , А.Ж. Байбусинова 
Published: October 2024

Шолуда дәнекер тіннің дисплазия (ДТД) мәселесі, кейіңгі кезде осы ақаумен кездесетін науқастардың жиілілігі ұлғайғанына байланысты оның финотиптік және висцералды көріністерінің ерекшеліктері талқыланатын болады. ДТД синдромының клиникалық қасиеттерінің полиморфизіміне әсер ететін арнайы көрсеткіштерге және тұқым қуалау бейімділігіне баға берілетін болады. Дисплазиясы бар науқастарда қаңқа кемістігінің клиникалық көрініс, буын гипермобилдігінің көрініс сатыслары P. Beighton, R. Wynne-Davis критериялары бойынша қарастырылған. Адам ағзасының тін мен көптеген ағзалардың құрылымдық негізін дәнекер тін құрайды, ол коллаген талшықтарының мықтылығына байланысты. Өкінішке орай айтылатын мәселергеосы уақытқа дейін шешілмеген көптеген сұрақтар бар.
In the review the problem were discussed connective tissue dysplasia in children, in recent years, frequent visceral and phenotypic traits. Hypermobility of the joints will be evaluated according to the criteria P. Beighton, R. Wynne-Davis. Structural basis of most organs and tissues in the human body is connective tissue, the strength of which is due to collagen fibers. It is known that when CTD is observed changes of many organs and systems. It is often secondary to chronic pathology determines the severity of the clinical condition and is the main reason patients visit a clinic. Unfortunately, in this problem to present tense there is many open question.
В обзоре рассмотренапроблема дисплазии соединительной ткани (ДСТ) у детей, и часто встречающиеся, в последнее время, висцеральные и фенотипические признаки ДСТ. Рассмотрены критерии оценки гипермобильности суставов по P. Beighton, R.Wynne-Davis. Структурную основу большинства органов и тканей в организме человека составляет соединительная ткань, прочность которой обусловлена коллагеновыми волокнами. Известно, что при ДСТ наблюдаются изменения многих органов и систем. Нередко, именно, вторичная хроническая патология определяет тяжесть клинического состояния и, является основной причиной обращения пациентов в медицинское учреждение. К сожалению, в решении проблемы ДСТ у детей существует ещё много нерешенных вопросов.
СРАВНЕНИЕ КОЛИЧЕСТВЕННЫХ ДАННЫХ ДВУХ ПАРНЫХ ВЫБОРОК С ИСПОЛЬЗОВАНИЕМ ПРОГРАММНОГО ОБЕСПЕЧЕНИЯ STATISTICA И SPSS: ПАРАМЕТРИЧЕСКИЕ И НЕПАРАМЕТРИЧЕСКИЕ КРИТЕРИИ
Authors: А.М. Гржибовский , С.В. Иванов , М.А. Горбатова 
Published: October 2024

В настоящей работе представлены общие сведения об использовании парного критерия Стьюдента, непараметрического критерия Вилкоксона и критерия знаков для сравнения количественных признаков парных выборок. Описан алгоритм расчета данных критериев с использованием программного обеспечения Statistica 10 и SPSS 20 и представлена интерпретация результатов расчетов. Настоящая статья призвана дать общие сведения об использовании парного критерия Стьюдента, парного критерия Вилкоксона и критерия знаков, и не заменяет прочтения специализированной литературы по статистике и клинической эпидемиологии.
In this article we present general information about Student’s paired t-test, non-parametric Wilcoxon test for paires samples and sign test which are often used for comparing paired numerical data. Algoritms for the use of all abovementioned criteria using Statistica 10 and SPSS 20 software are presented as well as recommendations on how to interpret results of the tests. This article covers basic knowledge needed for practical implementation of tests for paired observations (continuopus data) and does not substitute reading specialized literature in biostatistics and clinical epidemiology.
Осы жұмыста қосарлы іріктемелердің сандық белгілерін салыстыру үшін Стьюдент қосарлы критерилері және Вилкоксон параметрлік емес критерилерін қолдану туралы жалпы мәліметтер берілген. Statistica 10 және SPSS 20 бағдарламалыққамтамасыз етуді пайдаланумен критерилер мәліметтері есебінің алгоритмі суреттелген және есептер нәтижелерінің интерпретациясы берілген. Осы мақала Стьюдент қосарлы критерилері, Вилкоксон қосарлы критерилері және белгілер критерилерін қолдану туралы жалпы мәліметтер беруге талап етілген және статистика және клиникалық эпидемиология бойынша мамандандырылған әдебиетті оқудың орнын толтырмайды.
СРАВНЕНИЕ КОЛИЧЕСТВЕННЫХ ДАННЫХ ТРЕХ И БОЛЕЕ НЕЗАВИСИМЫХ ВЫБОРОК С ИСПОЛЬЗОВАНИЕМ ПРОГРАММНОГО ОБЕСПЕЧЕНИЯ STATISTICAИ SPSS: ПАРАМЕТРИЧЕСКИЕ И НЕПАРАМЕТРИЧЕСКИЕ КРИТЕРИИ
Authors: А.М. Гржибовский , С.В. Иванов , М.А. Горбатова 
Published: October 2024

В настоящей работе представлены общие сведения об использовании однофакторного дисперсионного анализа и непараметрического критерия Краскела-Уоллиса для сравнения количественных признаков трех и более независимых выборок. Описан алгоритм анализа данных с использованием программного обеспечения Statistica 10 и SPSS 20 и представлена интерпретация результатов расчетов. Настоящая статья призвана дать общие сведения об использовании однофакторного дисперсионного анализа, критерия Краскела-Уоллиса и проведении апостериорных сравнений групп, и не заменяет прочтения специализированной литературы по статистике и клинической эпидемиологии.
In this paper we summarise basic information on comparisons of three and more independent samples using one-way analysis of variance (one-way ANOVA) and non-parametric Kruskal-Wallis test. Detailed algorithms on how the abovementioned tests can be performed using Statistica 10 and SPSS 20 software are presented. Moreover, we describe peculiarities of interpretation of the results of one-way ANOVA and Kruskal-Wallis test. The aim of this article is to provide general information on the abovementioned statistical tests including post-hoc comparisons, but it does not substitute specialised literature on clinical epidemiology and beiostatistics.
Осы жұмыста үш және одан да көп іріктемелердің сандық белгілерін салыстыру үшін Краскела -Уоллистің бірфакторлы дисперсионды талдау параметрлік емес критерилерін қолдану туралы жалпы мәліметтер берілген. Statistica 10 және SPSS 20 бағдарламалық қамтамасыз етуді пайдаланумен критерилер мәліметтері есебінің алгоритмі суреттелген және есептер нәтижелерінің интерпретациясы берілген. Осы мақала Краскела - Уоллистің дисперсионды талдау параметрлік емес критерилерін қолдану және топтардың апостериорлық салыстырмалары өткізу туралы жалпы мәліметтер беруге талап етілген және статистика және клиникалық эпидемиология бойынша мамандандырылған әдебиетті оқудың орнын толтырмайды.
СРАВНЕНИЕ КОЛИЧЕСТВЕННЫХ ДАННЫХ ТРЕХ И БОЛЕЕ ПАРНЫХ ВЫБОРОК С ИСПОЛЬЗОВАНИЕМ ПРОГРАММНОГО ОБЕСПЕЧЕНИЯ STATISTICA И SPSS: ПАРАМЕТРИЧЕСКИЕ И НЕПАРАМЕТРИЧЕСКИЕ КРИТЕРИИ
Authors: А.М. Гржибовский , С.В. Иванов , М.А. Горбатова 
Published: October 2024

В настоящей работе представлены общие сведения об использовании дисперсионного анализа повторных измерений и непараметрического критерия Фридмана для сравнения количественных признаков трех и более связанных выборок. Описан алгоритм анализа данных с использованием программного обеспечения Statistica 10 и SPSS 20 и представлена интерпретация результатов расчетов. Настоящая статья призвана дать общие сведения об использовании дисперсионного анализа повторных измерений, критерия Фридмана и проведении апостериорных сравнений групп, и не заменяет прочтения специализированной литературы по статистике и клинической эпидемиологии.
In this paper of a series of articles where we describe basic principles of statistical data analysis using Statistica and SPSS software for beginners. Step-be-step algorithms for RM-ANOVA and Friedman test are presented. The main aim of this paper is to provide basic knowledge on RM-ANOVA and Friedman test with practical examples using popular software. The article complements, but does not substitute specialized literature on biostatistics and clinical epidemiology
Осы жұмыста үш және одан да көп байланысқан іріктемелердің сандық белгілерін салыстыру үшін Фридманның параметрлік емес критерилерін және қайта өлшеуді дисперсионды талдауды қолдану туралы жалпы мәліметтер берілген. Statistica 10 және SPSS 20 бағдарламалық қамтамасыз етуді пайдаланумен критерилер мәліметтері есебінің алгоритмі суреттелген және есептер нәтижелерінің интерпретациясы берілген. Осы мақала қайта өлшеуді дисперсионды талдауды, Фридманның критерилерін қолдану және топтардың апостериорлық салыстырмалары өткізу туралы жалпы мәліметтер беруге талап етілген және статистика және клиникалық эпидемиология бойынша мамандандырылған әдебиетті оқудың орнын толтырмайды.