bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of radiation cystitis treatment efficacy with glycosaminoglycan replenishment therapy
Authors: Mirkin Ya. B. , Ponomarenko A. M. , Karapetyan A. V. , Shumoff S. Yu. 
Published: July 2018

Background. Radiation cystitis is a severe late consequence of radiation therapy of pelvic malignancies. Destruction of glycosaminoglycan’s protective barrier (GAG-layer) plays key role in pathogenesis of radiation cystitis. Hence, GAG-replenishment therapy could be a promised method of treatment the radiation cystitis.The objective is to evaluate the effectiveness of glycosaminoglycan replacement therapy of chronic radiation cystitis using bladder instillation. Materials and methods. 23 female patients with radiation cystitis participated in the retrospective study. They have been randomized divided on two groups. Patients of the 1st group have been treated with intravesical administration of 0,08 % sodium hyaluronate alone, 2nd group – with intravesical sodium hyaluronate in combination with oral sodium hyaluronate and chondroitin sulfate.Results. Patients of both groups demonstrated less frequency and pain after treatment as well as increased bladder volume. Intravesical administration of glycosaminoglycans in combination with oral administration was more effective than intravesical therapy alone.Conclusions. GAG-replenishment therapy is a promised treatment options of radiation cystitis. Oral and intravesical GAG-replenishment therapy is more effective in comparison with only intravesical therapy.
33rd Annual Congress of the European Association of Urology in 2018: Review of oncological topics
Authors: Markova A. S. 
Published: July 2018

From 16 th to 20 th of March, 2018, the 33 rd Annual Congress of the European Association of Urology took place in Copenhagen. Doctors from 78 countries participated in the event. 4,381 abstracts were submitted, 1,338 of which were selected for poster sessions. Prostate cancer, kidney cancer, and bladder cancer were the most studied topics and constituted about a half of all accepted abstracts. In this article, a review of the most significant and interesting reports on cancer urology from the EAU Congress in 2018 is presented.
Prognostic factors of acute renal failure following partial nephrectomy of solitary kidney
Authors: Suslov L. N. , Sukonko O. G. , Mirilenko L. V. 
Published: July 2018

Background. Acute renal failure (ARF) in the postoperative period increases the risk of complications and death. Estimating the risk of ARF prior to surgery is particularly important, because it allows modifying the treatment in high-risk patients.Objective: to develop prognostic models for evaluating the risks of ARF in patients undergoing resection of a solitary kidney by measuring preoperative parameters.Materials and methods. The study included 136 patients with tumors in a solitary kidney that underwent surgical treatment in the N.N. Alexandrov National Cancer Center of Belarus in the last 16 years.Results. Biochemical blood tests demonstrated that 28 patients (20.6 %) had ARF in the early postoperative period. The multivariate model for assessing the risk of ARF included the following three covariates: tumor size, multifocality, and serum potassium level. We identified the cut-off points of tumor size (3.6 and 5.2 cm) and potassium level (4.4 and 4.8 mmol/L) that ensured maximum predictive accuracy. Using the multivariate model, we developed a nomogram that allows graphical calculation of the ARF probability in the postoperative period by measuring preoperative parameters.Conclusion. Our model enables preoperative assessment of the risk of developing ARF after resection of a solitary kidney with an accuracy (С-index) of 85.1 % (95 % confidence interval: 79.3–89.7 %).
CHARACTERISTIC OF EMERGENCY MEDICAL SERVICES TO THE PATIENT WITH CARDIOLOGICAL PROFILE IN THE SOUTH KAZAKHSTAN REGION
Authors: Beisenbaeva Zh. M. , Konovalov O. E. 
Published: July 2018

Purpose. Assessment of the received emergency medical services (EMS) in patients with cardiological profile in the South Kazakhstan region.Materials and methods. A sociological study was carried out among three compared groups: group 1 — patients of the regional cardiological center (312); 2nd — those who applied to rural outpatient clinics, polyclinics, hospitals (244), and the 3rd — who applied to the central district hospital (228).Results. The analysis showed that 65.1% of the respondents applied for EMS over the diseases of the circulatory system, mostly they did it 1–2 times a year (44.9%), less often several times a month (15.1%). Several times a week 5.1% of patients were called to EMS. It was found that in 65.5% of cases there was a rapid arrival of the EMS, less than 20 minutes. It should be noted that a long wait for the arrival of the EMS (45 minutes or more) took place in 10.2% of cases. The waiting time, as the reason for the dissatisfaction of the EMS, was more often called the respondents of the 2 nd and 3 rd groups — 94.1% and 93.9% versus 76.5% in the 1st group (p < 0.05). Inattentive attitude of the staff was more often noted by the patients of the 3rd group, and the low availability of free medication was most often indicated in the 1st group.Conclusion. The received characteristic of the EMS and its assessment by patients with diseases of the circulatory system should be taken into account when developing a package of measures to optimize cardiac care in the region.
Can Cytosine Arabinoside With Prednisolone Treatment for Canine Meningoencephalitis of Unknown Origin Increase Survival Time Compared to Prednisolone Treatment Alone?
Authors: Hoey Christopher Stefan Francis Kozlowski , Maunder Christina 
Published: July 2018

<strong>PICO question</strong><br /><p>In treatment of canine patients with meningoencephalitis of unknown origin (MUO), is combination therapy of cytosine arabinoside (CA) with prednisolone more effective than prednisolone as a sole therapy at increasing survival time?</p><strong>Clinical bottom line</strong><br /><p>Based on current available evidence, cytosine arabinoside with prednisolone has greater median survival time than prednisolone as a sole therapy in dogs with meningoencephalitis of unknown origin. The evidence to support this is very weak, as there are currently a low number of published papers with a relatively small number of cases reported in these studies evaluating cytosine arabinoside with prednisolone or prednisolone as a sole therapy for treatment of meningoencephalitis of unknown origin.</p><p> </p><img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />
FACTOR RELEATED OF ANTI-TUBERCULOSIS DRUG RESISTENCY ON PULMONARY TUBERCULOSIS PASIENT IN LABUANG BAJI HOSPITAL MAKASSAR
Authors: Saleh Sapriadi 
Published: July 2018

Tuberculosis is one of the infectious diseases that endanger health. The diseases can spread rapidly since it spreads through the air that happens when people suffering from tuberculosis are coughing and sneezing so that droplets containing Mycobacterium tuberculosis can be exposed to anyone who was around the patient. The general objective of this research is to analyze the factors that affect the anti-tuberculosis drug resistance in patients with pulmonary tuberculosis in hospitals Labuang Makassar Baji.Research design with cross sectional approach. This study was conducted in June-July 2017. With a total sample of 60 respondents based on inclusion and exclusion criteria. Based on the data analysis, it was found that the age group of 15-34 years were 34 respondents (56,7%), female were 35 respondents (58.3%), positive VCT test result was 15 respondents (25.0%), respondents who have medical history previously there were 54 respondents (90.0%), who had 45 respondents (78.3%) of TB contacts, who had good knowledge as many as 45 respondents (75.6%) who had PMO as many as 40 respondents (66.7%) , which states the behavior of good officers as much as 36 respondents (60.0%).The result of statistical test using Chi-Square test showed that there was a significant correlation between treatment history and OAT resistance with p = 0,024 <α = 0,05. While age, HIV infection, TB contact, Knowledge, Attitude behavior, and PMO have no significant relationship with OAT resistance. It is recommended to health care agencies to provide understanding to patients and families about TB treatment to prevent OAT resistance. Keywords Tuberculosis, Resistance, Anti Tuberculosis Medication
PENERAPAN KOMPETENSI PEDAGOGIS TENAGA PENDIDIK PAUD PADA PENCAPAIAN PERKEMBANGAN BAHASA DAN MATEMATIKA ANAK USIA DINI
Authors: Muzaqi Moh. 
Published: July 2018

Some of the teachersâ€™ competencies required in early childhood education are the competencies in pedagogy and andragogy. These competencies deal with teachersâ€™ skill in understanding childrenâ€™s development, preparing lesson plan, and using the right method and materials suitable to the childrenâ€™s characteristics. This research was conducted to discover how the teachers using pedagogy competency in language and mathematics in early childhood education. The result of this research was based on parentsâ€™ evaluation and observation on their childrenâ€™s development as they have learned language and mathematics in the early childhood education program.
Inovasi Media Pembelajaran Sosiologi Melalui Video Pembelajaran Bagi Guru SMA
Authors: Januarti Nur Endah , Pratiwi Poerwanti Hadi , Hendrastomo Grendi 
Published: July 2018

The community service is training for Sociologyâ€™s teachers in Bantul. This activity is to equip teachers about learning media knowledge and application of instructional media. There are many activities which are conducted to be applied and practiced in sociology classes so that sociology learning becomes interesting and not boring for learners. Training is done through varied lecture methods, discussions, and frequently asked questions. Various lecture methods are used to convey concepts that are important to be understood and mastered by the participants. The material given is the type and characteristics of instructional media. Learning media is devoted to learning videos. Question and discussion methods to provide opportunities for participants to consult in understanding the making of learning media and video learning. Making learning videos using the Windows Movie Maker program. From the training process the teacher is able to produce the learning video of class X, XI, XII. Video learning can be used in learning. Activity is supported by several factors. These factors are First, the existence of adequate experts from the Department of Education Sociology FIS UNY, the two participants are enthusiastic, the three principals who support the activities, and the four fa. The obstacles faced were the different basic abilities of participants and time management participants due to the various tasks of the school that caused their focus not to total training materials.
Keywords :Learning innovation, Video learning, Sociology, Senior high school
Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice
Authors: Marcuzzi Annalisa , Loganes Claudia , Celeghini Claudio , Kleiner Giulio 
Published: July 2018

Background:
Mevalonate Kinase Deficiency (MKD, OMIM #610377) is a rare
autosomal recessive metabolic and inflammatory disease. In MKD, defective function of the
enzyme mevalonate kinase, due to a mutation in the MVK gene, leads to the shortage of mevalonate-
derived intermediates, which results in unbalanced prenylation of proteins and altered
metabolism of sterols. These defects lead to a complex multisystem inflammatory and
metabolic syndrome.
<p>
Objective: Although biologic therapies aimed at blocking the inflammatory cytokine interleukin-
1 can significantly reduce inflammation, they cannot completely control the clinical
symptoms that affect the nervous system. For this reason, MKD can still be considered an
orphan drug disease. The availability of MKD models reproducing the MKD-systematic inflammation,
is crucial to improve the knowledge on its pathogenesis, which is still unknown.
New therapies are also required in order to improve pateints’ conditions and their
quality of life.
<p>
Methods: MKD-cellular models can be obtained by biochemical inhibition of mevalonatederived
isoprenoids. Of note, these cells present an exaggerated response to inflammatory
stimuli that can be reduced by treatment with zaragozic acid, an inhibitor of squalene synthase,
thus increasing the availability of isoprenoids intermediates upstream the enzymatic
block.
<p>
Results: A similar action might be obtained by lapaquistat acetate (TAK-475, Takeda), a
drug that underwent extensive clinical trials as a cholesterol lowering agent 10 years ago,
with a good safety profile.
<p>
Conclusions: Here we describe the preclinical evidence supporting the possible repositioning
of TAK-475 from its originally intended use to the treatment of MKD and discuss its
potential to modulate the mevalonate pathway in inflammatory diseases.
Study of Multi-factor Coordinated Frequency Control Strategy by DFIG Wind Turbine
Authors: Yin-Sha Wang , Wen-Yi Li , Zhi-Wen Li 
Published: July 2018

Background:
With the large-scale Doubly Fed Induction Generator (DFIG) wind turbine
integrated into the power system, the DFIG inertia response of the wind turbine should be provided.
Also, the frequency response should be similar to the conventional generation technologies. This paper
investigated the influence of frequency response term and wind speed conditions on system frequency
control.

Methods:
The specific operating conditions of four control strategies, including inertia control,
droop control, over speed control and pitch angle control were researched in this paper. Multi-factor
coordinated frequency control strategy of DFIG wind turbine was established based on the above researches.
The strategy was composed of wind speed ranging from low to high.

Results:
According to the simulation results, the DFIG wind turbine, which was based on multifactor
coordinated frequency control strategy, could respond to the system’s frequency change of
power grid, effectively.

Conclusion:
It helps system frequency return to stable states better and faster than DFIG wind turbine
and also could reduce the fluctuation of system frequency.
Reliability, Learnability and Efficiency of Two Tools for Cement Crowns Retrieval in Dentistry
Authors: Bignardi Cristina , Zanetti Elisabetta M. , Terzini Mara , Ciccola Anna R. , Schierano Gianmario , Audenino Alberto L. 
Published: July 2018

Background:
Tooth-supported fixed dentures are commonly used in restorative dentistry, and have definitely reached a high survival rate; nevertheless, their removal is sometimes required mainly due to caries or other failures (poor fit, poor cementation and so on). Removing a definitive partial denture is not trivial since the used cement is not always known and it may be very resistant; additionally, there are various clinical circumstances in which a conservative disassembly would be desirable.

Objective:

assessing the performance of different tools for cement crowns retrieval in terms of reliability, learnability and efficiency.

Methods:
An experimental study has been performed on two different devices for conservative crown/bridge removal: a manual tool that is a sliding hammer, and an automatic tool, powered by compressed air. Both skilled and unexperienced operators have been considered and an experimental set up has been appositely designed in order to measure force versus time patterns. The peak applied force has been taken as an output variable for the evaluation of tool performance.

Results:
The automatic tool improves both the inter-operator and the intra-operator reliability, respectively from 79% to 95%, and from 69% to 92%. Additionally, the force pattern is significantly different between these two tools: the instrument powered by compressed air, produces a sharper peak force, as required to break fragile materials such as dental crown cement, and its efficiency can be estimated to be 75% higher. Both tools have a high learnability since the performances of experienced and unexperienced operators have not proved to be significantly different.

Conclusion:
A methodology has been set up to compare tools for cement crowns retrieval. The compressed-air tool has been proved to generally provide a better performance unless more ductile cement is to be broken.
RESIDUAL DEFORMITY AFTER BILATERAL KNEE ARTHROPLASTY: IMPACT ON SHORT TERM OUTCOMES
Authors: Zinoviev M. P. , Paskov R. V. , Sergeev S. K. , Rimashevsky D. V. 
Published: July 2018

Purpose — to evaluate the impact of frontal positioning of prosthesis components after bilateral Tka on short term functional outcomes. Material and Methods. The authors performed a retrospective analysis of teleroentgenograms of 466 patients after bilateral Tka with initial varus deformity. Functional and roentgenological outcomes were evaluated at average in 16,4±2,9 months postoperatively. Mean preoperative varus deformity was 10° (from 5 to 25°), initial angle between the anatomical and mechanical femoral axis (FVa) was 6,7±2° (from 3 to 12°). The neutral axis of both lower limbs (Hka = 180±0,5°) was obtained in 99 (21,2%) out of 466 patients. Residual deformity in one of the limbs above 3° with the neutral alignment of the contralateral limb was observed in 44 (9,4%) patients, bilateral residual deformity – in 32 (6,9%) patients. Other 291 patients demonstrated the deviation from mechanical axis in the range from 1 to 3° (±0,5°). all patients were divided into three groups: first group consisted of 10 patients with neutral axis of one limb and varus deformity of the other limb above 3°; second group — 10 patients with bilateral residual varus deformity above 3°; third group — 12 patients with neutral axis of both limbs (Hka = 180°). The angle of residual deformity averaged 3,7° (from 3,2 to 5,1°).Results. No statistically significant differences between the groups were observed for dynamometric parameters and SF-36 scores, as well as for functional kSS scores (p0,05). However, the authors reported in patients of the first group a stance phase on the side of residual varus deformity longer at 15% (p0,05) and transfer phase shorter at 17% (p0,05) as compared to contralateral limb (with neutral alignment, Hka = 180°), which is indicative of load asymmetry and can have a negative impact at a later stage.Conclusion. Symmetrical residual varus deformity of lower limbs in the rage of 3,2–5,1° has no negative impact of short term clinical and functional outcomes of Tka. Muscular function and gait properties in patients with neutral axis of the lower limbs and in patients with symmetrical residual varus deformity after Tka were similar 16,4±2,9 months postoperatively.
A Mobile Game for Patients With Breast Cancer for Chemotherapy Self-Management and Quality-of-Life Improvement: Randomized Controlled Trial
Authors: Kim Hee Jun , Kim Sun Mi , Shin Heechul , Jang Joung-Soon , Kim Young In , Han Doug Hyun 
Published: July 2018

Background
The application of game-based learning in clinical practice has shown potential advantages in previous studies. However, there have been little efforts to use smartphone-based mobile games in the management of adult patients with cancer.

Objective
The objective of our study was to evaluate if patient education using a mobile game may increase drug compliance, decrease physical side effects of chemotherapy, and improve psychological status in breast cancer patients.

Methods
A total of 76 patients with metastatic breast cancer who were planned to receive cytotoxic chemotherapy were enrolled in this trial. Study participants were randomly assigned to a mobile game play group (game group, n=36) or a conventional education group (control group, n=40) in a ratio of 1:1. The patients were unblinded and followed prospectively for 3 weeks. Outcome measures included time spent for education, compliance to medication, physical side effects, and psychological side effects including quality of life (QoL).

Results
Overall, 72 out of 76 patients completed the study after 3 weeks (95%). The subjects in the game group showed high levels of satisfaction with the app. The time spent playing the mobile game in the game group was longer than that spent for self-education in the control group (mean 22.2, SD 6.1 vs mean 5.5, SD 4.0 minutes a day; P<.001). The mobile game group showed better drug adherence (Korean version of the Medication Adherence Rating Scale; mean 7.6, SD 0.7 vs mean 6.5, SD 0.5; P<.001). The use of the mobile game was associated with lower rates of chemotherapy-related side effects, such as nausea, fatigue, numbness of hand or foot, and hair loss, than the control group. The game group exhibited better QoL during chemotherapy (mean 74.9, SD 3.5 vs mean 72.2, SD 5.3; P=.01). However, there were no significant differences in terms of depression and anxiety scales.

Conclusions
This study suggests the feasibility and potentiality of the use of smartphone mobile games for patients with breast cancer receiving chemotherapy. Education using a mobile game led to better patient education, improved drug compliance, decreased side effects, and better QoL compared with conventional education. Mobile games can be used as easy, fun, and effective measures for patient education and have the potential to improve treatment outcomes.

Trial Registration
ClinicalTrials.gov NCT03205969; http://clinicaltrials.gov/ct2/show/NCT03205969 (Archived by WebCite at http://www.webcitation.org/71jfSBOq9).
O carvão da Jazida de Morungava (RS, Brasil): Caracterização petrográfica, química e tecnológica das camadas de carvão do poço de exploração CBM 001-MO-RS
Authors: SIMÃO Gustavo , KALKREUTH Wolfgang 
Published: July 2018

Tendo em vista a necessidade ampliação da matriz energética nacional, torna-se premente desenvolver estudos em jazidas carboníferas não exploradas (e.g. Jazida de Morungava), onde pesquisas ulteriores datam da década de 1980. A fonte mineral situa-se no nordeste do Rio Grande do Sul, ocupando uma área de 250 km2 . Para avaliar o potencial da jazida carbonífera (CBM- 001-MO-RS) e sua economicidade, foi realizada a caracterização petrográfica, química e tecnológica das camadas obtidas (num total de seis), com 387,70 m de profundidade, espessura cumulativa de carvão de 9,22 m. Obteve-se um total de 27 amostras, utilizadas à determinação dos seguintes parâmetros: descrição de litotipos do carvão, refletância da vitrinita, contagem de macerais, análises imediatas, poder calorífico superior, enxofre total, difração de raios-X e teste de beneficiamento. O litotipo carvão fosco predomina nas amostras, com um rank variando de carvão betuminoso alto volátil A a antracito. As distintas camadas apresentam progressiva intrusão vulcânica sotoposta. O grupo maceral vitrinita predomina nos carvões na porção inferior, enquanto inertinita predomina na superior. Matéria mineral tende a apresentar acréscimos da base ao topo. Os carvões apresentaram elevados teores de cinza (>50% m.b.s.), matéria volátil (6,04-30,69% m.b.s), enxofre (0,20-2,88% m.b.s.) e poder calorífico superior (777-4.732 Kcal/Kg). Há predomínio mineralógico de quartzo, caulinita, e illita. Muitas das camadas são classificadas como rocha carbonosa (>50% cinza/b.s.). Os ensaios de beneficiamento indicaram baixo rendimento (<7% vol.) na obtenção de produtos nobres.