bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facetime vs. Screentime: Gaze Patterns to Live and Video Social Stimuli in Adolescents with ASD
Authors: Grossman R. B. , Zane E. , Mertens J. , Mitchell T. 
Published: September 2019

AbstractAtypical eye gaze to social stimuli is one of the most frequently reported and studied social behaviors affected by autism spectrum disorder (ASD). The vast majority of this literature is based on analyses of gaze patterns as participants view social information, such as talking faces, on a computer screen. However, recent results suggest that generalizing gaze behaviors from computer screens to live interactions may not be valid. This study examines between- and within-group differences in gaze behaviors of children with ASD and their neurotypical (NT) peers during a screen-based and a live-interaction task. Results show between-group differences in gaze only for the screen-based, but not the live-interaction task. We also find that gaze behavior of NT children during the screen-based task significantly correlates with their gaze behavior during the live interaction; individuals who direct a higher percentage of gaze to the face in one task also did so in the other task. However, there is no significant relationship between the gaze patterns of children with ASD for those two tasks. These results strongly caution against using gaze of individuals with ASD recorded during screen-based tasks as a proxy for understanding their gaze behavior during live social interactions.
Label-free Imaging of Tissue Architecture during Axolotl Peripheral Nerve Regeneration in Comparison to Functional Recovery
Authors: Uckermann Ortrud , Hirsch Joana , Galli Roberta , Bendig Jonas , Later Robert , Koch Edmund , Schackert Gabriele , Steiner Gerald , Tanaka Elly , Kirsch Matthias 
Published: September 2019

AbstractHuman peripheral nerves hold the potential to regenerate after injuries; however, whether a successful axonal regrowth was achieved can be elucidated only months after injury by assessing function. The axolotl salamander is a regenerative model where nerves always regenerate quickly and fully after all types of injury. Here, de- and regeneration of the axolotl sciatic nerve were investigated in a single and double injury model by label-free multiphoton imaging in comparison to functional recovery. We used coherent anti-Stokes Raman scattering to visualize myelin fragmentation and axonal regeneration. The presence of axons at the lesion site corresponded to onset of functional recovery in both lesion models. In addition, we detected axonal regrowth later in the double injury model in agreement with a higher severity of injury. Moreover, endogenous two-photon excited fluorescence visualized macrophages and revealed a similar timecourse of inflammation in both injury models, which did not correlate with functional recovery. Finally, using the same techniques, axonal structure and status of myelin were visualized in vivo after sciatic nerve injury. Label-free imaging is a new experimental approach that provides mechanistic insights in animal models, with the potential to be used in the future for investigation of regeneration after nerve injuries in humans.
Optimal HIV testing strategies for South Africa: a model-based evaluation of population-level impact and cost-effectiveness
Authors: Johnson Leigh F. , van Rensburg Craig , Govathson Caroline , Meyer-Rath Gesine 
Published: September 2019

AbstractAlthough many African countries have achieved high levels of HIV diagnosis, funding constraints have necessitated greater focus on more efficient testing approaches. We compared the impact and cost-effectiveness of several potential new testing strategies in South Africa, and assessed the prospects of achieving the UNAIDS target of 95% of HIV-positive adults diagnosed by 2030. We developed a mathematical model to evaluate the potential impact of home-based testing, mobile testing, assisted partner notification, testing in schools and workplaces, and testing of female sex workers (FSWs), men who have sex with men (MSM), family planning clinic attenders and partners of pregnant women. In the absence of new testing strategies, the diagnosed fraction is expected to increase from 90.6% in 2020 to 93.8% by 2030. Home-based testing combined with self-testing would have the greatest impact, increasing the fraction diagnosed to 96.5% by 2030, and would be highly cost-effective compared to currently funded HIV interventions, with a cost per life year saved (LYS) of $394. Testing in FSWs and assisted partner notification would be cost-saving; the cost per LYS would also be low in the case of testing MSM ($20/LYS) and self-testing by partners of pregnant women ($130/LYS).
VIVA (VIsualization of VAriants): A VCF File Visualization Tool
Authors: Tollefson G. A. , Schuster J. , Gelin F. , Agudelo A. , Ragavendran A. , Restrepo I. , Stey P. , Padbury J. , Uzun A. 
Published: September 2019

AbstractHigh-throughput sequencing produces an extraordinary amount of genomic data that is organized into a number of high-dimension datasets. Accordingly, visualization of genomic data has become essential for quality control, exploration, and data interpretation. The Variant Call Format (VCF) is a text file format generated during the variant calling process that contains genomic information and locations of variants in a group of sequenced samples. The current workflow for visualization of genomic variant data from VCF files requires use of a combination of existing tools. Here, we describe VIVA (VIsualization of VAriants), a command line utility and Jupyter Notebook based tool for evaluating and sharing genomic data for variant analysis and quality control of sequencing experiments from VCF files. VIVA combines the functionality of existing tools into a single command to interactively evaluate and share genomic data, as well as create publication quality graphics.
Adipocytes initiate an adipose-cerebral-peripheral sympathetic reflex to induce insulin resistance during high-fat feeding
Authors: Cao Wei , Shi Meng , Wu Liling , Li Jiaxin , Yang Zhichen , Liu Youhua , Wilcox Christopher S. , Hou Fan Fan 
Published: September 2019

Abstract
The underlying mechanism by which amassing of white adipose tissue in obesity regulates sympathetic nerve system (SNS) drive to the tissues responsible for glucose disposal, and causes insulin resistance (IR), remains unknown. We tested the hypothesis that high-fat (HF) feeding increases afferent impulses from white adipose tissue that reflexively elevate efferent nerve activity to skeletal muscle (SM) and adipose tissue to impair their local glucose uptake. We also investigated how salt-intake can enhance IR. HF-fed rats received a normal salt (0.4%) or high salt (4%) diet for 3 weeks. High-salt intake in HF fed rats decreased insulin-stimulated 2-deoxyglucose uptake by over 30% in white adipose tissue and SM, exacerbated inflammation, and impaired their insulin signaling and glucose transporter 4 (Glut4) trafficking. Dietary salt in HF fed rats also increased the activity of the adipose-cerebral-muscle renin–angiotensin system (RAS) axes, SNS, and reactive oxygen species (ROS). Insulin sensitivity was reduced by 32% in HF rats during high-salt intake, but was improved by over 62% by interruption of central RAS and SNS drive, and by over 45% by denervation or deafferentation of epididymal fat (all P&lt;0.05). Our study suggest that a HF diet engages a sympathetic reflex from the white adipose tissue that activates adipose-cerebral-muscle RAS/ROS axes and coordinates a reduction in peripheral glucose uptake. These are all enhanced by salt-loading. These findings provide new insight into the role of a reflex initiated in adipose tissue in the regulation of glucose homeostasis during HF feeding that could lead to new therapeutic approaches to IR.
Transition bei ADHS
Authors: Alvarez Fischer Daniel , Zimmermann Carolin , Rudolph Frank Matthias , Bubenzer Rainer H. , Kis Bernhard 
Published: September 2019

ZUSAMMENFASSUNGDer Übergang vom Kindesalter ins Erwachsenenalter stellt die Behandlung persistierender Erkrankungen wie die Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) vor große Herausforderungen. Während noch 43 % aller Jugendlichen mit ADHS eine medikamentöse Behandlung erhalten, fällt dieser Anteil bei den Anfang zwanzigjährigen Patienten auf unter 20 % ab. Welche Faktoren eine Persistenz der ADHS vorhersagen ist nicht geklärt. Unter den Risikofaktoren finden sich aber neben einer erhöhten Krankheitsschwere auch komorbide Erkrankungen wie eine Depression. Der Artikel widmet sich der Frage nach Faktoren, die eine gelungene Transition begünstigen. Da in die Zeit der Transition die Berufswahl fällt, geht der Artikel der Frage nach, welche Voraussetzungen bei einer Tätigkeit gegeben sein sollten. Bis auf wenige Ausnahmen sind grundsätzlich jedoch alle Berufe für Menschen mit ADHS möglich. Abschließend geht der Artikel auf die Behandlungsmöglichkeiten und die Versorgungssituation für Patienten mit ADHS in Deutschland ein. Die Effektstärken einer medikamentösen Behandlung des ADHS sind hoch, ein Behandlungserfolg ist in den Zulassungsstudien > 60 % der Betroffenen zu erwarten. Eine Verhaltenstherapie (allein oder in Kombination mit Stimulanzien), Stimulanzien und Nichtstimulanzien sind in der Behandlung deutlich wirksamer als Placebo.
Psychoedukation bei Patienten mit adulter ADHS
Authors: Bender Matthias , Wehmeier Peter M. , Wolff Jan , Scherk Harald 
Published: September 2019

ZUSAMMENFASSUNGIn diesem Artikel wird eine Übersicht über psychoedukative Interventionen bei adulter ADHS gegeben, bestehende Manuale beschrieben, ein Praxisbeispiel einer Spezialambulanz im versorgungspsychiatrischen Spektrum mit Responsemessungen sowie die Studienlage zur Wirksamkeit referiert. Psychoedukation und Coaching kommt als psychotherapeutischer Basisintervention ein besonderer Stellenwert in einem multimodal angelegten Gesamtbehandlungskonzept der ADHS zu. Mittels Psychoedukation sollen die Betroffenen als auch ihre Angehörigen in der emotionalen Verarbeitung und der Akzeptanz der Diagnose unterstützt werden sowie umfassend über ihre Störung und adäquate Behandlungsmöglichkeiten inklusive der Pharmakotherapie aufgeklärt werden. Darüber hinaus sollen Selbstmanagement-Fertigkeiten geschult, Leidensdruck reduziert sowie die Funktionsfähigkeit und Alltagsadaptation verbessert werden.
Entspannung mit dem Smartphone bei Migräne?
Authors: Kamm Katharina 
Published: September 2019

ZusammenfassungIn der Migränebehandlung ist die Progressive Muskelrelaxation (PMR) ein leitliniengerechtes verhaltenstherapeutisches Entspannungsverfahren. Da nicht alle Patienten Zugang zu (realen) Kopfschmerztherapeuten und den entsprechenden Behandlungen haben, untersuchten die Autoren, ob eine Smartphone-Applikation für die Anwendung von PMR (RELAXaHEAD App) bei Migränepatienten erfolgreich eingesetzt werden kann.
Krankheitskosten – Einsparpotenzial bei
Lebertransplantationen
Authors: Thiem Helena 
Published: September 2019

Harries L et al. Potential savings in the treatment pathway of liver
transplantation: an inter-sectorial analysis of cost-rising factors. Eur J
Health Econ 2019: 20: 281–301
Lebertransplantationen sind äußerst komplexe medizinische Eingriffe, in die
viele Akteure aus dem Gesundheitssektor involviert ist. Entsprechend hoch
ist der Ressourcenverbrauch bei einem solchen Eingriff. Durch eine gezielte
Ressourcenallokation könnten Einsparpotenziale realisiert werden, ohne die
Behandlungsqualität zu beeinflussen. Unter dieser Annahme identifizierten
die Autoren um Harries et al. die kostenverursachenden Faktoren einer
Lebertransplantation.
Salmonella Osteomyelitis in a Healthy Child: Case Report and Review of Literature
Authors: Carranco Dueñas José Alberto , Sánchez Hernández Genny , Gálvez Martínez Rosa Edith 
Published: September 2019

Abstract
Salmonella osteomyelitis is a rare entity, typically associated with hemoglobinopathies or other underlying disorders. We report a case of Salmonella osteomyelitis of the right knee in an otherwise healthy 1-year-old boy. He received 8 weeks (2 weeks intravenous and 6 weeks oral) of antibiotic treatment, with full recovery.
Comparison of the standards for absorbed dose to water of the NPL, United Kingdom and the BIPM for 60Co γ rays
Authors: Kessler C , Burns D T , Kelly M , Maughan D J , Bass G A , Shipley D R , Sander T , Lee N D , Cashmore M , Duane S 
Published: September 2019

A key comparison of the standards for absorbed dose to water of the National Physical Laboratory (NPL), United Kingdom and of the Bureau International des Poids et Mesures (BIPM) was carried out in the 60Co radiation beam of the BIPM in November 2017. The comparison result, based on the calibration coefficients for two transfer standards and expressed as a ratio of the NPL and the BIPM standards for absorbed dose to water, is 1.0013 with a combined standard uncertainty of 7.1×10-3. The results are analysed and presented in terms of degrees of equivalence, suitable for entry in the BIPM key comparison database.
KEY WORDS FOR SEARCH
Radiation dosimetry, key comparison, absorbed dose to water, 60Co

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Construction and analysis of puncture clamp model for 10KV insulation line based on finite element
Authors: Wu Shaolei , Feng Yu , Shi Xun , Zhang Xu , Huang Peng 
Published: September 2019

Abstract
At present, the puncture clamp has been widely used in the cable branching technology. However, due to the complicated installation process, the clamping force is too large during installation, resulting in cable damage and reduced life. If the clamping force is too small, it may cause poor contact or even cause fire. In this paper, the 3D solid model of the puncture clamp is established by using SolidWorks 3D software. Then the finite element analysis model of the puncture clamp is established in the finite element analysis software ANSYS Workbench, and the static analysis and exploration of the puncture clamp are obtained. The results show that the puncture blade and the conductor on the puncture clamp have the greatest contact stress and the maximum amount of deformation of the bolt, while the bolt meets the required strength. The results can be used to further optimize the structural design of the puncture clamps, refine the installation specifications and guide the installation.
Research on flexible control algorithm for acceleration/deceleration in heavy-duty motion
Authors: Yuan Lei , Xu Mingjin , Wu Zhenxing , Xu Jin 
Published: September 2019

Abstract
An algorithm for acceleration/deceleration control is proposed in this paper to improve the flexibility of the heavy-duty motion system. The algorithm is based on the five-segment S-type acceleration/deceleration curve. During the acceleration switching time, a circular arc is used to smooth the curve, and the running time of each stage could be reasonably allocated by cyclic iteration. A parameter is defined to quantify the degree of flexibility of the acceleration/deceleration process to match the actual project. This paper will build the model to compare the good and bad point of different algorithms. The result shows that the vibration and impact during the acceleration and deceleration process can be effectively reduced, which means that the flexibility of the system has been greatly improved.
FE analyses and structural optimization on refitted floating container
Authors: Liu Yuan , Ye Hu , Geng Baogang , Zhou Jianglong , Li Yunfei 
Published: September 2019

Abstract
On the basis of the requirements of river-crossing emergency traffic guarantee, a structural modification was exerted on 40-foot Dry Cargo Container. A structure of refitted floating container was designed, which could be used in the assembly of emergency floating bridge. A finite element method (FEM) theoretical analysis was made on the static strength and stiffness of refitted floating container. Two kinds of load levels were brought in as the typical working conditions. Modelling in the ANSYS circumstance to simulation analysis and accomplishing optimization design based on the results. The results show that the floating bridge system assembled by refitted floating containers can’t support the load under the level of wheel type-20 and crawler type-500 for a stress concentration appears on the contact sites between floating container and main girder. The maximum stress goes beyond the limit of yield strength. An structural optimization was made to eliminate the influence of stress concentration and floating bridge system assembled by refitted floating containers can meet the requirements of load level of wheel type-20 and crawler type-500 after optimization. The refitted floating container can play a role in transporting troops and engineering emergency task crossing the river in a short period of time.
Multi-objective optimization of economic thickness of insulated compartment for refrigerator vehicles
Authors: Ye Lei , Li Jin , Xie Ruhe , Huang Chaowei 
Published: September 2019

Abstract
Aiming at the multi-objective design problem for the refrigerated compartment, an optimal design model of the refrigerated compartment was established. The actual constraints of depreciation of insulating material for compartments increased the cost of transportation due to insulating materials and the cost of refrigeration due to compartment body transfer, compartment sealing and respiratory heat of cargo, its main design parameters were comprehensively considered. The maximum available space of the compartment and the minimum cost of single transporting were selected as objective function. Parameters of the refrigerated compartment were optimized with MATLAB software, and the available space of the refrigerated compartment and the cost of single transporting under different parameters were analyzed. Results showed that the optimized design method was suitable for refrigerated compartment. The optimized results of available space of refrigerated compartment and the cost of single transporting were different under different conditions. When the heat insulation material was respectively foaming with polystyrene, extruded polystyrene, polyurethane, in a longer transporting mileage from 50 to 500km, the corresponding optimal thickness of insulating materials of compartment body was thicker. Under the condition that the available space of refrigerated compartment reached the maximum and single transportation cost of the refrigerated compartment reached the minimum at the same time, when the average transporting mileage was 50km, the corresponding optimal thickness of heat insulation material was 0.11m with polystyrene, 0.09m with extruded polystyrene and 0.08m with polyurethane, while the available space of the refrigerated compartment was 12.0892m3, 12.7820m3, and 13.1375m3 respectively, and the corresponding cost of single transporting was CNY 5453.27, 4964.24 and 4847.98.
Disassembly simulation of main pipe insulation layer of nuclear power plant pressure vessel based on DELMIA
Authors: Li Jianguang , Fan Yibo , Sheng Xuanyu , Wang Lanwen 
Published: September 2019

Abstract
In order to ensure that the temperature of the main feed water and the main steam pipe is at the design value, there is a thick insulation layer outside the main pipe line. According to the requirements of the specification, after a certain period of time, the insulation layer here needs to be replaced. However, due to the relatively high dose of radioactivity here, maintenance personnel are subject to a certain dose of radiation. We use 3D ergonomics simulation method to establish a 3D model of the scene here, simulate the correct disassembly and installation process of the operator, make the maintenance personnel familiar with the environment and operation process, reduce errors, shorten the operation time, and finally shorten the inspection cycle. This achieves increased safety and reduced overhaul time at low cost.
Application research of solidworks in modeling of straw carbonization preparation plant
Authors: Wu Di , Zhang Zhixia , Wang Zixin 
Published: September 2019

Abstract
This article focuses on the basic overview, main functions of and specific applications solidworks software in the field of agricultural preparation. Namely the modeling design of the screw feeder in the orchard fertilizing machine, the design of a small elastic toothed pepper harvester and in-depth analysis of the application of various aspects such as the application of the sugarcane harvester drainage device design. In the meantime the in-depth study of the practicality and advancement of the Solidworks software in the field of agricultural preparation, as well as the specific use of the software and its advantages briefly stated. It is expected to play an important role in promoting the application of the software in the field of agricultural preparation and promote related enterprises to achieve greater development in the field of agricultural preparation and to improve the competitiveness of enterprises in the market in order to meet the needs of modern social and economic development.
Research on measurement path planning of complex object
Authors: Zhao Xiaolong , Li Lijuan , Liu Yue , Liu Tao , Hou Maosheng 
Published: September 2019

Abstract
In the past automatic measurement system for three-dimensional shape of complex parts, there was no corresponding measurement scheme for the groove-shaped complex parts, which there existed problems such as low work efficiency and large measurement error. In order to solve this problem, this paper is based on the principle of raster scanning projection measurement, and explores the mathematical model of projection grating trigonometry theory, and analyzes the different characteristics of scattered geometric features such as walls and edges inside the groove in complex parts. Combined with the scanning constraints such as the inclination angle and depth of field of the 3D scanner, the method of measuring the path planning of the groove-shaped complex parts was proposed and studied. Finally, the measurement path planning verification experiment was carried out, which is based on the above analysis. The results show that the position deviation during the measurement process is within 0.001mm, the angular deviation is within 0.009°, which proves the feasibility of the measurement path for the groove-shaped complex parts.
Research on heat dissipation of car seat optimizing based on ARIZ analysis
Authors: Liu Chunmeng , Dong Juan , Yang Xin , Xue Bingyang , Wu Fei , Shi Fu 
Published: September 2019

Abstract
The heat dissipation of car seat back is poor if there is no extra ventilation system. This paper applied ARIZ (Algorithm of Inventive Problem Solving) to get 6 proposals to optimize the heat dissipation of car seat back. Various TRIZ (Theory of Inventive Problem Solving) methods were used, such as Function Model, Cause and Effect Chain, Contradiction Analysis, Substance Field and SLP (smart little people) and so on. All these methods were used by a logical structured process (ARIZ) which incrementally evolves the complex problem to a point where it was simple to solve.