bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curative endovascular treatment for low-grade Spetzler-Martin brain arteriovenous malformations: a single-center prospective study
Authors: Iosif Christina , de Lucena Adson Freitas , Abreu-Mattos Luiz Gustavo , Ala Victor Hugo Espindola , El-Ghanam Amin , Saleme Suzana , Caire Francois , Mounayer Charbel 
Published: January 2019

BackgroundThe treatment of low grade Spetzler-Martin (SM) brain arteriovenous malformations (AVMs) has been debated in unruptured cases. Nevertheless, in clinical practice there are cases where treatment is preferred; in these cases a very low complication rate is mandatory. In ruptured cases, early and complete obliteration of the nidus is the preferred strategy.ObjectiveTo achieve curative embolization, ideally in a single session, by dual microcatheterization techniques with arterial and/or venous access, according to the angioarchitecture.Materials and methodsThis is a prospective, single-center study carried out between January 2008 and January 2016. Patients with ruptured and unruptured brain AVMs, with SM grades I and II, treated by endovascular means, were included. Demographics, clinical presentation, angioarchitecture, and procedure-related complications were analyzed. Angiographic and clinical results were reported.ResultsSeventy-three patients, aged 40.5±17.8 years, were included. More than 60% of the patients presented with ruptured AVMs. Initial SM grades were I for 22% and II for 78% of the patients. Preprocedural modified Rankin Scale (mRS) score was 0–2 for 53 (72.6%), 3 for 12 (16.4%), 4 for 5 (6.8%) and 5 for 3 (4.1%) patients. Procedure-related morbidity was 2.7% and procedure-related mortality was 0%. Ninety percent (90.5%) of the patients were independent in their everyday lives (mRS score 0–2) at 6 months. In all but one case (95%) the embolization was curative.ConclusionStand-alone endovascular treatment for SM grade I and II brain AVMs seems safe and effective, allowing for complete obliteration of the nidus, with low complication rates. A study of larger cohorts is needed.
HP–UHP metamorphism and tectonic evolution of orogenic belts: introduction
Authors: Zhang Lifei , Zhang Zeming , Schertl Hans-Peter , Wei Chunjing 
Published: January 2019

Abstract

High pressure (HP) and ultrahigh pressure (UHP) metamorphic rocks play a key role for understanding the tectonic evolution of orogenic belts (Johnson, M.R.W. & Harley, S.L. 2012.
Orogenesis: The Making of Mountains
. Cambridge University Press, Cambridge). They have typically experienced complex changes during subduction and exhumation processes, arising from recrystallization, deformation, element redistribution, fluid–rock interactions and even partial melting, and may therefore carry a valuable record of evolving geodynamic systems in an orogenic belt. Until now, more than 20 UHP metamorphic belts, i.e. belts which contain rocks that experienced pressure–temperature (
P–T
) conditions exceeding the lower limit of the coesite stability field, have been identified all over the world (Carswell, D.A. & Compagnoni, R. 2003.
Ultrahigh Pressure Metamorphism
. Eotvos University Press, European Mineralogical Union, Notes in Mineralogy, Budapest; Liou, J.G., Ernst, W.G., Zhang, R.Y., Tsujimori, T. & Jahn, B.M. 2009. Ultrahigh-pressure minerals and metamorphic terranes – the view from China.
Journal of Asian Earth Sciences,
35
, 199–231; Zheng, Y.F., Zhang, L.F., McClelland, W.C. & Cuthbert, S. 2012. Processes in continental collision zones: preface.
Lithos
,
136
, 1–9). New and innovative studies from different geoscience disciplines have been invaluable in developing a better understanding of the geodynamic evolution of orogenic belts. This special issue contains 15 papers, most of which were presented as part of the session ‘HP–UHP metamorphism and tectonic evolution of orogenic belts’, held at the 35th International Geological Congress in Cape Town, South Africa during 27 August to 4 September, 2016.
TRPV1 channels contribute to spontaneous glutamate release in nucleus tractus solitarii following chronic intermittent hypoxia
Authors: Kline David D. , Wang Sheng , Kunze Diana L. 
Published: January 2019

Chronic intermittent hypoxia (CIH) reduces afferent-evoked excitatory postsynaptic currents (EPSCs) but enhances basal spontaneous (s) and asynchronous (a) EPSCs in second-order neurons of nucleus tractus solitarii (nTS), a major area for cardiorespiratory control. The net result is an increase in synaptic transmission. The mechanisms by which this occurs are unknown. The N-type calcium channel and transient receptor potential cation channel TRPV1 play prominent roles in nTS sEPSCs and aEPSCs. The functional role of these channels in CIH-mediated afferent-evoked EPSC, sEPSC, and aEPSC was tested in rat nTS slices following antagonist inhibition and in mouse nTS slices that lack TRPV1. Block of N-type channels decreased aEPSCs in normoxic and, to a lesser extent, CIH-exposed rats. sEPSCs examined in the presence of TTX (miniature EPSCs) were also decreased by N-type block in normoxic but not CIH-exposed rats. Antagonist inhibition of TRPV1 reduced the normoxic and the CIH-mediated increase in sEPSCs, aEPSCs, and mEPSCs. As in rats, in TRPV1+/+ control mice, aEPSCs, sEPSCs, and mEPSCs were enhanced following CIH. However, none were enhanced in TRPV1−/− null mice. Normoxic tractus solitarii (TS)-evoked EPSC amplitude, and the decrease after CIH, were comparable in control and null mice. In rats, TRPV1 was localized in the nodose-petrosal ganglia (NPG) and their central branches. CIH did not alter TRPV1 mRNA but increased its protein in NPG consistent with an increased contribution of TRPV1. Together, our studies indicate TRPV1 contributes to the CIH increase in aEPSCs and mEPSCs, but the CIH reduction in TS-EPSC amplitude occurs via an alternative mechanism. NEW & NOTEWORTHY This study provides information on the underlying mechanisms responsible for the chronic intermittent hypoxia (CIH) increase in synaptic transmission that leads to exaggerated sympathetic nervous and respiratory activity at baseline and in response to low oxygen. We demonstrate that the CIH increase in asynchronous and spontaneous excitatory postsynaptic currents (EPSCs) and miniature EPSCs, but not decrease in afferent-driven EPSCs, is dependent on transient receptor potential vanilloid type 1 (TRPV1). Thus TRPV1 is important in controlling nucleus tractus solitarii synaptic activity during CIH.
The Influence of Plantar Short Foot Muscle Exercises on the Lower Extremity Muscle Strength and Power in Proximal Segments of the Kinematic Chain in Long-Distance Runners
Authors: Sulowska Iwona , Mika Anna , Oleksy Łukasz , Stolarczyk Artur 
Published: January 2019

The aim of this study was to evaluate the influence of plantar short foot muscles exercises on the performance of lower extremities in long-distance runners. 47 long-distance runners aged 21-45 years took part in this study. The participants were divided into two groups based on baseline measurement of Foot Posture Index: Group 1 (n=27) with neutral foot and Group 2 (n=20) with slight and increased pronation. The participants performed the exercises daily for 6 weeks. The knee flexors and extensors torque, work, and power on Isokinetic Dynamometer and Running-Based Anaerobic Sprint Test (RAST) were checked at baseline and after 6 weeks of exercises. Higher values of peak torque of knee flexors were observed. This change was statistically significant at high load with angular velocity 90°/s (73.55 Nm at baseline and 89.05 Nm after 6 weeks) and 160°/s (69.40 Nm at baseline and 79.00 Nm after 6 weeks) in Group 2. In both groups higher values of maximum power were noted. Participants in Group 2 achieved lower values in each 35-metre run time and higher values of power. In Group 2 there was significant improvement of total time (35.26 s at baseline and 34.79 s after 6 weeks) compared to Group 1 (37.33 s at baseline and 37.56 s after 6 weeks). Exercises strengthening short foot muscles may improve energy transfer through body segments and increase strength and values of generated power. They should be included as a part of daily training programme of runners. This study was registered in the Australian New Zealand Clinical Trials Registry (ANZCTR). Registration number: ACTRN12615001200572.
Type I Protein Arginine Methyltransferases Overexpression Promotes Transformation and Potentiates Her2/Neu–Driven Tumorigenesis
Authors: Watson Zachary L. , Bitler Benjamin G. 
Published: January 2019

Abstract

Bao and colleagues demonstrate that type I protein arginine methyltransferases (PRMT) are directly involved in mammary gland transformation and tumor progression. Notably, several distinct phenotypes require further investigation such as PRMT1/CARM1–induced transformation, CARM1-mediated delay in tumorigenesis, and PRMTs potentiation of Her2-dependent tumors. The PRMT overexpression transgenic mouse models should encourage and facilitate further mechanistic interrogation and the development of PRMT-directed therapies.
See related article by Bao et al., p. 21
Low Expression of the Androgen-Induced Tumor Suppressor Gene PLZF and Lethal Prostate Cancer
Authors: Stopsack Konrad H. , Gerke Travis , Tyekucheva Svitlana , Mazzu Ying Z. , Lee Gwo-Shu Mary , Chakraborty Goutam , Abida Wassim , Mucci Lorelei A. , Kantoff Philip W. 
Published: January 2019

Abstract

Background:
4%–9% of prostate cancers harbor homozygous deletions of the androgen-induced tumor suppressor gene, promyelocytic leukemia zinc finger (PLZF, ZBTB16). PLZF loss induces an in vitro phenotype of castration resistance and enzalutamide resistance. The association of low expression of PLZF and clinical outcomes is unclear.

Methods:
We assessed PLZF mRNA expression in patients diagnosed with primary prostate cancer during prospective follow-up of the Health Professionals Follow-up Study (HPFS; n = 254) and the Physicians' Health Study (PHS; n = 150), as well as in The Cancer Genome Atlas (n = 333). We measured PTEN status (using copy numbers and IHC) and transcriptional activation of the MAPK pathway. Patients from HPFS and PHS were followed for metastases and prostate cancer–specific mortality (median, 15.3 years; 113 lethal events).

Results:
PLZF mRNA expression was lower in tumors with PLZF deletions. There was a strong, positive association between intratumoral androgen receptor (AR) signaling and PLZF expression. PLZF expression was also lower in tumors with PTEN loss. Low PLZF expression was associated with higher MAPK signaling. Patients in the lowest quartile of PLZF expression compared with those in the highest quartile were more likely to develop lethal prostate cancer, independent of clinicopathologic features, Gleason score, and AR signaling (odds ratio, 3.17; 95% confidence interval, 1.32–7.60).

Conclusions:
Low expression of the tumor suppressor gene PLZF is associated with a worse prognosis in primary prostate cancer.

Impact:
Suppression of PLZF as a consequence of androgen deprivation may be undesirable. PLZF should be tested as a predictive marker for resistance to androgen deprivation therapy.
Contexto da contribuição de Cândido Aragonez de Faria na modernização das diagonais barrocas
Authors: Bari Valéria Aparecida , Rodrigues Raul Felipe Silva 
Published: January 2019

Estudo sobre a vida e obra de Cândido Aragonez de Faria, enfatizando sua contribuição na modernização das diagonais barrocas, como recurso de comunicação da narrativa sequencial gráfica. Contribuiu para o Jornalismo brasileiro e latino-americano, com impecável texto poliglota e imagens de rara expressão, levou a irreverência, a beleza e o humor de sua arte às propagandas de Paris da Belle Epoche. Sua atuação, sempre pioneira e inédita, o colocou entre os melhores chargistas e ilustradores do mundo em sua época. No entanto, o Brasil da atualidade obnubilou sua lembrança e a França o tem para si como um patrimônio artístico, custodiado pelo Museu do Louvre e pela Biblioteca Nacional. O resgate de sua memória é importante, para retomar a identidade brasileira de seu trabalho e abrir possibilidades de aprimoramento da composição barroca aplicada às narrativas sequenciais gráficas, como recurso de aprimoramento das mídias impressas e digitais no séc. XXI.
Patient Body Mass Index and Physician Radiation Dose During Coronary Angiography
Authors: Madder Ryan D. , VanOosterhout Stacie , Mulder Abbey , Ten Brock Taylor , Clarey Austin T. , Parker Jessica L. , Jacoby Mark E. 
Published: January 2019

Background:
Consistent with the increasing prevalence of obesity in the general population, obesity has become more prevalent among patients undergoing cardiac catheterization. This study evaluated the association between patient body mass index (BMI) and physician radiation dose during coronary angiography.

Methods and Results:

Real-time radiation exposure data were collected during consecutive coronary angiography procedures. Patient radiation dose was estimated using dose area product. Physician radiation dose in each case was recorded by a dosimeter worn by the physician and is reported as the personal dose equivalent (H
p
10). Patient BMI was categorized as <25.0, 25.0 to 29.9, 30.0 to 34.9, 35.0 to 39.9, and ≥40. Among 1119 coronary angiography procedures, significant increases in dose area product and physician radiation dose were observed across increasing patient BMI categories (
P
<0.001). Compared with a BMI <25, a patient BMI ≥40 was associated with a 2.1-fold increase in patient radiation dose (dose area product, 91.8 [59.6–149.2] versus 44.5 [25.7–70.3] Gy×cm
2
;
P
<0.001) and a 7.0-fold increase in physician radiation dose (1.4 [0.2–7.1] versus 0.2 [0.0–2.9] μSv;
P
<0.001). By multiple regression analysis, patient BMI remained independently associated with physician radiation dose (dose increase, 5.2% per unit increase in BMI; 95% CI, 3.0%–7.5%;
P
<0.0001).

Conclusions:
Among coronary angiography procedures, increasing patient BMI was associated with a significant increase in physician radiation dose. Additional studies are needed to determine whether patient obesity might have adverse effects on physicians, in the form of increased radiation doses during coronary angiography.
Dychotomia pamięci w postkomunistycznej Bułgarii
Authors: Gołek-Sepetliewa Dorota 
Published: January 2019

The dichotomy of memory in post-communist BulgariaThe democratic breakthrough of 1989 in Bulgaria has resulted in a clearly problem-oriented approach of society towards memory and the past. The process of developing an efficient model of reckoning with the traumatic heritage of communism divides the national community into dichotomous memory groups with their own understanding, assessment and modes of using the past. Developing a memory policy without a clear institutional support (Georgi Lozanov) oscillates between the attitudes of retribution and reconciliation (Ana Luleva, Svetla Kazalarska). Bulgarian society is characterised by a lack of remembrance of the past and its excess at the same time (Ivaĭlo Znepolski). The recent national past remains unprocessed, which results in the emancipation of private memory, characterised by the ability to overcome the impasse thanks to reliance on shared, non-conflicting, fragmentary memories of ordinary reality (Az zhiviakh sotsializma, I lived socialism, Georgi Gospodinov, et al.). As it is today, Bulgarian culture of memory is characterised by diverse collective memories, the multiplication of conflicts over the interpretation of the past and the fragmentation of memory, which leads to growing antagonisms and social crises. Dychotomia pamięci w postkomunistycznej BułgariiPrzełom demokratyczny z 1989 roku w Bułgarii spowodował wyraźne sproblematyzowanie stosunku społeczeństwa do pamięci i przeszłości. Wypracowanie modelu rozliczenia z traumatycznym dziedzictwem komunizmu dzieli wspólnotę narodową na dychotomiczne grupy pamięci, posiadające własne rozumienie, ocenę i sposób wykorzystywania przeszłości. Tworzone polityki pamięci, nieposiadające wyraźnego umocowania instytucjonalnego (Georgi Łozanow), oscylują między postawami retrybucji oraz rekoncyliacji (Ana Łulewa, Swetła Kazałarska). Społeczeństwo bułgarskie charakteryzuje się jednoczesnym niedostatkiem i nadmiarem pamięci o przeszłości (Iwajło Znepołski). Nieprzepracowana niedawna przeszłość narodowa powoduje emancypację pamięci prywatnej, którą cechuje zdolność przełamania impasu, dzięki oparciu na wspólnych niekonfliktogennych fragmentarycznych wspomnieniach potocznej rzeczywistości (Аз живях социализма, Georgi Gospodinow i inni). W bułgarskiej kulturze pamięci dochodzi do różnicowania się pamięci zbiorowej, mnożenia konfliktów o interpretację minionego okresu oraz fragmentacji pamięci, co doprowadza do pogłębiających się antagonizmów i kryzysów społecznych.
"Z życia zostaje co?..." Prof. dr hab. Algis Kalėda (2.10.1952 – 11.05.2017)
Authors: Kasner Małgorzata 
Published: January 2019

“What remains of life?...”Prof. Dr hab. Algis Kalėda (2.10.1952 – 11.05.2017)This article is devoted to Professor Algis Kalėda, a renowned Lithuanian literary scholar, specialist in Polish literature and Lithuanian comparative literary studies, and a prominent translator of Polish literature. Over the years he worked at scholarly institutions in Lithuania (including the Institute of Lithuanian Literature and Folklore, Vilnius University Centre of Polish Studies, Vilnius Pedagogical Institute) and Poland (including Warsaw University, Jagiellonian University, Adam Mickiewicz University in Poznań). He collaborated with leading researchers from all over the world. Professor Kalėda left us the great legacy of his scholarly works and literary translations (from such authors as Czesław Miłosz, Wisława Szymborska and Stanisław Lem). The title of the article, “What remains of life?...”, is a quote from Czesław Miłosz’s poem “Notatnik: Bon nad Lemanem”, translated into English by George (György) Gömöri and Clive Wilmer: “From a notebook: Bon on Lake Geneva”, Poetry Nation Review 9, Vol. 6 No. 1, September–October 1979, https://www.pnreview.co.uk/cgi-bin/scribe?item_id=6270 Z życia zostaje co?...Prof. dr hab. Algis Kalėda (2.10.1952 – 11.05.2017)Artykuł został poświęcony pamięci Profesora Algisa Kalėdy – wybitnego litewskiego badacza: polonisty i lituanisty, komparatysty, tłumacza, w pierwszą rocznicę śmierci. Profesor Algis Kalėda przez długie lata był związany z litewskimi (m.in. wileńskim Instytutem Literatury Litewskiej i Folkloru, Centrum Polonistycznym Uniwersytetu Wileńskiego, Wileńskim Instytutem Pedagogicznym) i polskimi instytucjami naukowymi (Uniwersytetem Warszawskim i tamtejszą lituanistyką, Uniwersytetem Jagiellońskim, Uniwersytetem im. Adama Mickiewicza w Poznaniu). Współpracował z wybitnymi naukowcami z całego świata. Profesor Algis Kalėda pozostawił wybitną spuściznę badawczą oraz znakomite przekłady literatury polskiej na język litewski (m.in. Czesława Miłosza, Wisławy Szymborskiej, Stanisława Lema). Tytuł artykułu Z życia zostaje co?... jest cytatem z wiersza Czesława Miłosza Notatnik: Bon nad Lemanem (Brzegi Lemanu).
Who fought for national freedom? On the significance of the Great War in interwar Lithuania
Authors: Safronovas Vasilijus 
Published: January 2019

Who fought for national freedom? On the significance of the Great War in interwar LithuaniaEven though the First World War was caused by tension in the east of Europe, not so long ago, quite a number of historians, as if repeating the words of Winston Churchill, tended to portray the Eastern Front in Europe as an “unknown war”. Not only was the war in the east little known, but the remembrance of the war in Eastern Europe remains little investigated. Lithuania is one of the countries in the region where for a long time nothing was known about the remembrance of the Great War. Many historians argued that this kind of remembrance simply did not exist. The article invites us to reconsider this statement by paying attention to the question of how the merits of different actors in the struggle for national freedom were interpreted and represented in interwar Lithuania. Instead of painting a monolithic picture of Lithuania, the article proposes to look at its society as a fragmented construct, whose different parts offered a rather ambiguous answer to the question. Kto walczył o niepodległość? O interpretacji znaczenia I wojny światowej na Litwie w okresie międzywojennymPomimo że I wojna światowa była wynikiem napięć w Europie Wschodniej, to jeszcze niedawno wielu historyków opisywało działania na froncie wschodnim jako „nieznaną wojnę”, nawiązując tym samym do słów Winstona Churchilla. Zaniedbanym obszarem badań była nie tylko sama wojna na Wschodzie, lecz również pamięć o niej w tej części kontynentu. Litwa jest jednym z krajów regionu, gdzie pamięć o Wielkiej Wojnie długo pozostawała zjawiskiem zupełnie nieznanym, a wielu historyków dowodziło, że takiej pamięci po prostu nie ma. Niniejszy artykuł zachęca do zrewidowania tej opinii i zwraca uwagę na kwestię oceny i interpretacji zasług różnych uczestników walk o niepodległość Litwy w okresie międzywojennym. Artykuł proponuje spojrzenie na litewskie społeczeństwo nie jak na monolit, lecz fragmentaryczny konstrukt, w którym różne środowiska udzielały różnych odpowiedzi na postawione w tytule pytanie.
Wprowadzenie: o kulturze pamięci w Europie Środkowej i Wschodniej
Authors: Kasner Małgorzata , Kvietkauskas Mindaugas 
Published: January 2019

Introduction: On culture of memory in Central and Eastern EuropeThis issue of the Acta Baltico-Slavica, entitled “Bałtyckie i słowiańskie konteksty (nie) pamięci” (The Baltic and Slavic contexts of (non-)memory, vol. 42/2018), is devoted to interdisciplinary research on culture of memory, which – after Christoph Cornelißen – we understand as a formal notion superior to all possible forms of conscious memory of past events. This volume presents the state of research on memory from the perspective of two turning points in European history: 1918 and 1989. The events immediately following the fall of empires and the communist regime (including the rise of new states, shifts and modifications of state borders, international and ethnic conflicts, transformation of political and economic systems) not only changed the geopolitical map, but also exerted enormous influence on shaping identity and memory of Europeans and their historical and biographical narrations. Wprowadzenie: o kulturze pamięci w Europie Środkowej i WschodniejTegoroczny numer rocznika „Acta Baltico-Slavica” zatytułowany Bałtyckie i słowiańskie konteksty (nie)pamięci został poświęcony interdyscyplinarnym badaniom nad kulturą pamięci, którą rozumiemy zgodnie z definicją Ch. Cornelißena jako „formalne pojęcie nadrzędne dla wszelkich możliwych form świadomej pamięci człowieka o wydarzeniach historycznych, osobistościach i procesach, niezależnie od tego, czy są one natury estetycznej, politycznej czy poznawczej”. Celem niniejszego tomu jest przedstawienie stanu badań nad pamięcią z perspektywy dwóch szczególnie ważnych dla Europy cezur dziejowych: 1918 roku i 1989 roku. Wydarzenia, które nastąpiły bezpośrednio po upadku imperiów i reżimu komunistycznego (m.in. powstanie nowych państw, przesunięcia i zmiany granic, konflikty międzypaństwowe i narodowościowe, transformacja systemu politycznego i gospodarczego) nie tylko zmieniły mapę geopolityczną, ale także wywarły ogromny wpływ na kształtowanie się tożsamości i pamięci Europejczyków, ich narracji historycznych i biograficznych.