bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognosis of nasopharyngeal carcinoma with insufficient radical dose to the primary site in the intensity‐modulated radiotherapy era
Authors: Lu Tianzhu , Xie Xingyun , Guo Qiaojuan , Zhan Shenghua , Lin Cheng , Lin Shaojun , Zhang Yu , Zong Jingfeng , Pan Jianji 
Published: July 2019

AbstractBackgroundIt was reported that reduced radiotherapy is feasible for children with nasopharyngeal carcinoma (NPC) and papilloma virus‐positive oropharyngeal cancer. Therefore, we performed this study to explore the prognosis of reduced‐dose radiation in adult with NPC.MethodsBetween 2004 and 2013, we retrospectively analyzed 19 patients histologically diagnosed with NPC, who received <66 Gy radiation therapy. Ten patients receiving <54 Gy to the primary site were group A. Nine patients receiving ≥54 Gy were group B.ResultsThirteen patients received induction chemotherapy (IC) for two or three cycles. In group A, the 5‐year overall survival (OS) was 50.0%. For group B, the 5‐year OS, locoregional relapse‐free survival, progression‐free survival, and distant metastasis‐free survival were 88.9%, 100.0%, 88.9%, and 88.9%. Group B had a better prognosis than group A on OS (88.9% vs 50.0%, P = .03).ConclusionPatients receiving ≥54 Gy but <66 Gy with IC achieved good local control and long‐term survival.
Co‐creating a program for teams to maintain and reflect on their flexibility
Authors: van Gool Frank W.R. , Bierbooms Joyce J.P.A. , Bongers Inge M.B. , Janssen Richard T.J.M. 
Published: July 2019

SummaryTo prevent rigidity within teams in health care and to support teams in detecting early warning signs of decreasing flexibility, a program has been co‐created in collaboration with mental healthcare teams. This program is intended to systematically monitor team behavior, and by doing so to facilitate team intervention. We aim to lay foundations for the further development of methods that can help teams to recognize and respond to processes going on under the surface.This paper introduces the program to the reader; and describes its premises and the co‐creation process, leading to a program of nine steps. Then, it describes the application of the program within a team, what a team needs to use the program, and whether the nine steps are sufficient.This pilot shows that the program is a helpful framework within which teams can talk about rigidity, define indicators of their flexibility, and think about appropriate actions and interventions for maintaining or restoring their flexibility. Team ownership and the customizability of the program are important attributes. The program appears to provide a useful framework that helps a team to observe and discuss processes. Team members become aware of the indicators of their team and make their goals explicit.
A randomised controlled trial of the Adult Resilience Program: A universal prevention program
Authors: Games Natalie , Thompson Claire L. , Barrett Paula 
Published: July 2019

A randomised, waitlist controlled, trial was conducted to evaluate the effects of the Adult Resilience Program (ARP), a universal prevention social–emotional programme for adolescents and adults, on self‐reported depression, anxiety, stress, resilience, and self‐esteem. Seventy‐six students from a private university in Singapore were randomised to the ARP group or wait‐list control (WLC) group and assessments were conducted at pre‐intervention (T1), post‐intervention (T2), and 6‐month follow‐up (T3). A 2 × 3 mixed between‐within groups multivariate analysis of variance with the between‐group factor of Group (ARP, WLC) and the within‐group factor of time (T1, T2, and T3) and the dependent variables of depression, anxiety, stress, resilience and self‐esteem, with age and stage of degree as covariates showed a significant decrease over time in depression (ηp2 = .20), and anxiety (ηp2 = .06). There was a significant decrease in stress for the ARP only from T1 to T2 (ηp2 = .16). While there was a significant interaction of Time and Group for resilience (ηp2 = .07), there was no significant change in resilience for the ARP group alone. The results provide preliminary support that the ARP can impart essential skills that can have a positive impact on mental health in university students.
INFLUENCE OF A FIXED WATER DISPERSION DEVICE ON JET DISPERSION AND RANGE FROM AN IMPACT SPRINKLER
Authors: Li Hong , Issaka Zakaria , Jiang Yue , Tang Pan , Chen Chao 
Published: July 2019

AbstractFixed water dispersion breaks up and disperses the jet issuing from the nozzle of an impact sprinkler continuously upon impingement. The performance of an impact sprinkler is influenced by the spatial distribution of the dispersed droplets. The objective of this study was to investigate the influence of a fixed water dispersion device on jet dispersion and range from an impact sprinkler. A series of experiments were conducted using high‐speed photography technology to capture images for analysis. A model of the jet was developed and applied in a MatLab computation program to determine the initial jet breakup lengths and the angles of dispersion. Comparison of the calculated values with other formulas indicated an average relative error of less than 10%. The spreading angle was wider with increased working pressure and insertion depth in the jet stream from the device. A semi‐empirical formula of spray range for the test sprinkler with a fixed water dispersion device was established through curve fitting. Because the new formula depends on the angle of dispersion, it may be useful as a simple and quick way to estimate the dispersion and uniformity of water distribution within the area irrigated. © 2019 John Wiley & Sons, Ltd.
Different paths and same destinations? An analysis of the convergence in Internet usage patterns between different age groups
Authors: Barrantes Roxana , Vargas Eduardo 
Published: July 2019

AbstractThe present article delves into the understanding of the digital gap that divides the younger age groups from those who are older, specifically the young (17‐30), adults (31‐45), mature adults (46‐60), and older adults (61‐75). The analysis carried out in three capital cities of Latin America (Buenos Aires, Lima, and Guatemala City) finds that there is a pattern of convergence in the trajectory of Internet appropriation of users belonging to different age groups. However, the gap between the younger groups and the older group does not close completely, even after several years of experience using the Internet. Likewise, it is observed that the adoption of more sophisticated activities on the Internet is conditioned by characteristics specific to each age group.
Fluorescence studies of the interaction between chloramphenicol and nitrogen‐doped graphene quantum dots and determination of chloramphenicol in chicken feed
Authors: Tsai Hweiyan , Hu Hsiao‐Ching , Hsieh Chih‐Chung , Lu Yi‐Hsuan , Chen Chien‐Hong , Fuh Chwan‐Bor 
Published: July 2019

AbstractChloramphenicol (CAP) is a veterinary antibiotic that has been banned due to its severe side effects in humans. Through the application of manure, veterinary antibiotics can enter the soil, where they can be taken up by crops and vegetables and pose a potential health hazard to humans. Thus, it is highly desirable to develop a rapid and sensitive tool for on‐site detection of CAP to ensure food safety and to control the abuse of antibiotics. To this end, nitrogen‐doped graphene quantum dots (N‐GQDs) were successfully prepared via microwave‐assisted synthesis using citric acid and urea as carbon and nitrogen sources, respectively. Analytical results suggested that the interaction between N‐GQDs and CAP could occurs via π‐π stacking, which quenched N‐GQD fluorescence. CAP spiked into chicken feed could be rapidly extracted with ethanol and quantified based on N‐GQD fluorescence quenching without further separation. This method showed good recovery (97–102.6%), a low detection limit (1.8 ppm), and was not affected by interference from florfenicol, and thiamphenicol, legal substitute antibiotics. This method has excellent potential for determination of CAP in livestock feed and soil.
Deoxypyridinoline‐bioinspired supramolecular antibacterial salts with a C—H⋯O hydrogen‐bonded tetrameric host to construct the helical scaffold and sheet structures: The importance of rotational flexibility, anion shapes, and robust C—H⋯O hydrogen bonding
Authors: Hung Hui‐Yu , Hsu Ching‐I , Wu Che‐Kai , Wen Hsin‐Yi , Lee Kwang‐Ming 
Published: July 2019

AbstractA new flexible hydrogen‐bonded supramolecular host based on two deoxypyridinoline‐bioinspired 6‐hexanoic acid‐substituted 3‐hydroxypyridinium cations that adopt the twist and planar conformations and construct the orthogonal single helical scaffold and sheet structures with the triangular NO3− and spherical Br− guest anions, respectively. The results demonstrated not only the importance of rotational flexibility, anion shapes, and robust C—H⋯O hydrogen bonding, but also the good antibacterial activity with the potential antibacterial application.
Novel oral transforming growth factor‐β signaling inhibitor potently inhibits postsurgical adhesion band formation
Authors: Soleimani Atena , Asgharzadeh Fereshteh , Rahmani Farzad , Avan Amir , Mehraban Saeedeh , Fakhraei Maryam , Arjmand Mohammad Hassan , Binabaj Maryam Moradi , Parizadeh Mohammad Reza , Ferns Gordon A. , Ryzhikov Mikhail , Afshari Amir Reza , Naghinezhad Jalal , Sayyed‐Hosseinian Sayyed Hadi , Khazaei Majid , Hassanian Seyed Mahdi 
Published: July 2019

AbstractHere, we have investigated the therapeutic potency of EW‐7197, a transforming growth factor‐β type I receptor kinase inhibitor, against postsurgical adhesion band formation. Our results showed that this pharmacological inhibitor prevented the frequency and the stability of adhesion bands in mice model. We have also shown that downregulation of proinflammatory cytokines, reduce submucosal edema, attenuation of proinflammatory cell infiltration, inhibition of oxidative stress, decrease in excessive collagen deposition, and suppression of profibrotic genes at the site of surgery are some of the mechanisms by which EW‐7197 elicits its protective responses against adhesion band formation. These results clearly suggest that EW‐7197 has novel therapeutic properties against postsurgical adhesion band formation with clinically translational potential of inhibiting key pathological responses of inflammation and fibrosis in postsurgery patients.
Socio‐economic Status, Demographic Characteristics and Intimate Partner Violence
Authors: Wilson Nicholas 
Published: July 2019

AbstractOne in three ever‐partnered women worldwide has experienced intimate partner violence (IPV), yet there is little systematic global evidence on the association between socio‐economic status (SES), demographic characteristics and IPV. This paper uses information from more than one‐quarter of one million female respondents age 15–49 in IPV modules from 36 Demographic and Health Surveys to provide detailed evidence on IPV gradients around the developing world. The analysis reveals relatively large negative IPV–SES gradients for respondent years of schooling and household wealth. Marriage and higher age are generally associated with lower IPV, whereas the physical violence–age profile follows an inverted U‐shape. © 2019 John Wiley & Sons, Ltd.
Clinical findings in Brazilian patients with adult GM1 gangliosidosis
Authors: Giugliani Luciana , Steiner Carlos Eduardo , Kim Chong Ae , Lourenço Charles Marques , Santos Mara Lucia Schmitz Ferreira , de Souza Carolina Fischinger Moura , Brusius‐Facchin Ana Carolina , Baldo Guilherme , Riegel Mariluce , Giugliani Roberto 
Published: July 2019

AbstractGM1 gangliosidosis is a lysosomal storage disorder caused by β‐galactosidase deficiency. To date, prospective studies for GM1 gangliosidosis are not available, and only a few have focused on the adult form. This retrospective cross‐sectional study focused on clinical findings in Brazilian patients with the adult form of GM1 gangliosidosis collected over 2 years. Ten subjects were included in the study. Eight were males and two females, with median age at diagnosis of 11.5 years (IQR, 4‐34 years). Short stature and weight below normal were seen in five out of the six patients with data available. Radiological findings revealed that the most frequent skeletal abnormalities were beaked vertebrae, followed by hip dysplasia, and platyspondyly. Neurological examination revealed that dystonia and swallowing problems were the most frequently reported. None of the patients presented hyperkinesia, truncal hypertonia, Parkinsonism, or spinal cord compression. Clinical evaluation revealed impairment in activities of cognitive/intellectual development and behavioral/psychiatric disorders in all nine subjects with data available. Language/speech impairment (dysarthria) was found in 8/9 patients, fine motor and gross motor impairments were reported in 7/9 and 5/9 patients, respectively. Impairment of cognition and daily life activities were seen in 7/9 individuals. Our findings failed to clearly identify typical early or late alterations presented in GM1 gangliosidosis patients, which confirms that it is a very heterogeneous condition with wide phenotypic variability. This should be taken into account in the evaluation of future therapies for this challenging condition.
Modification of genital kidney nephrons for sperm transport in a plethodontid salamander, Eurycea longicauda
Authors: Hartley Jordan , Gribbins Kevin M. , Siegel Dustin S. 
Published: July 2019

AbstractSalamanders possess kidneys with two distinct regions: a caudal pelvic portion and cranial genital portion. Nephrons of the pelvic region are responsible for urine formation and transport. Nephrons of the genital region transport sperm from testes to Wolffian ducts; however, nephrons of the genital region possess all the same functional regions found in pelvic kidney nephrons that are involved with urine formation and transport (renal corpuscles, proximal tubules, distal tubules, and collecting ducts). Morphological similarities between pelvic and genital regions stimulated past researchers to hypothesize that nephrons of genital kidneys possess dual function; that is, sperm transport and urine formation/transport. Considering size of glomeruli is directly related to the total amount of blood plasma filtered into the Bowman's space, we tested the hypothesis that nephrons of genital kidneys have reduced urine formation function by comparing glomerular size between nephrons of pelvic and genital kidney regions in Eurycea longicauda with general histological techniques. Light microscopy analysis revealed that glomeruli of pelvic kidneys were significantly larger than those measured from genital kidneys. Transmission electron microscopy analysis also revealed modifications in genital kidney nephrons when compared to pelvic kidney nephrons that suggested a decrease in urine formation function in genital kidneys. Such modifications included a decrease in basal and lateral plasma membrane folding in genital kidney proximal and distal tubules compared to that of pelvic kidney proximal and distal tubules. Genital kidney proximal tubules were also ciliated, which was not observed in pelvic kidney proximal tubules. In conclusion, although structurally similar at the histological level, it appears that nephrons of genital kidneys have decreased urine formation function based on glomerular size comparison and nephron ultrastructure.
Anatomy, histology, and histochemistry of the olfactory organ of the Korean shuttles mudskipper Periophthalmus modestus
Authors: Kim Hyun T. , Yun Seung W. , Park Jong Y. 
Published: July 2019

AbstractThe Korean shuttles mudskipper Periophthalmus modestus has paired olfactory organs on its snout, consisting of anterior and posterior nostrils, a single olfactory canal with sensory and nonsensory epithelia, and a single accessory nasal sac. Its sensory epithelium consists of numerous islets forming a pseudostratified layer and contains various cells: olfactory receptor neurons, supporting cells, basal cells, lymphatic cells (LCs), and axon bundles. The sensory epithelium is a stratified squamous layer comprising stratified epithelial cells, mucous cells (MCs) with glycogen, flattened cells (FCs), LCs, and unidentified cells. Specific structures are as follows: (a) a tubular anterior nostril projecting outward, (b) a slit posterior nostril, (c) an elongated olfactory canal, (d) an ethmoidal accessory nasal sac, (e) axon bundles found only in the basal layer of the sensory epithelium, (f) FCs only at the top of the nonsensory epithelium, and (g) glycogen‐containing MCs. Such structures seem to be unique in that they have not been observed in most teleost fishes spending their whole life in water.
Rapid MALDI‐TOF molecular imaging: Instrument enhancements and their practical consequences
Authors: Vestal Marvin , Li Lingjun , Dobrinskikh Evgenia , Shi Yatao , Wang Bowen , Shi Xudong , Li Sicheng , Vestal Christina , Parker Kenneth 
Published: July 2019

AbstractA new high performance linear MALDI‐TOF mass spectrometer provides both high spatial resolution and high speed. This instrument employs a new ion optics system with a grounded ion source and efficient transfer and detection of ions over a broad mass range. This provides very high sensitivity, precision, and an extended dynamic range for both positive and negative ion detection. Here we demonstrate the capabilities of this system by imaging pancreatic tissue samples from rats and mice.
Electromagnetic hyperthermia on porous model of hepatic cancerous tissue
Authors: Shamekhi Leila , Sayehvand Habib‐Olah , Karami Hamidreza 
Published: July 2019

AbstractBecause the effectiveness of interstitial hyperthermia is related to the temperature distribution achieved during the process, accurate understanding of energy transport within biological organs is necessary. This strongly depends on the complexity of the extended model. Herein, the coupled nonlinear set of transient equations for electromagnetic, momentum, and energy has been extended under two layered porous medium approximation. Maximum temperature value as well as its position has been traced in time by applying local thermal non‐equilibrium (LTNE). The boundary between cancerous and normal tissue has continuously been respected by different properties. The extended model is solved by a new computational approach. The results lead to a special slow and continuous moving antenna to achieve more effective cancerous cell death via normal cell safety.
Toward higher extraction and enrichment factors via a double‐reservoirs microfluidic device as a micro‐extractive platform
Authors: Rezvani Omid , Baraazandeh Maryam , Bagheri Habib 
Published: July 2019

AbstractIn this study, firstly, a double‐reservoir and switchable prototype of a micro‐chip along with the respective holders were fabricated. A cyclic desorption process using microliter volume of organic solvent was adopted to prevent any outdoor contamination. As extractive phases, two identical sheets of electrospun polyamide/polypyrrole/titania nanofibers were synthesized using core–shell electro‐spinning technique and utilized for determination of memantine in plasma samples. Field emission scanning electron microscopy images showed a high degree of porosity and homogeneity throughout the sheet structure. Also, energy dispersive X‐ray analysis confirmed the presence of titania, while the recorded Fourier transform infrared spectra proved the chemical structures of the polymeric mats. The incorporation of titania as well as polypyrrole in the composition of polyamide nanofibers improved both mechanical stability and extraction capacity of the extractive phase and therefore facilitated the extraction/desorption process. The limits of detection and quantification were 0.01 and 0.04 ng/mL, respectively. In addition, the interday and intraday precisions were lower than 6.7% (n = 3). The linearity was in the range of 0.14–75.00 ng/mL, while recoveries were between 94.1 and 98.4% with the regression coefficient of 0.9987.
Antibodies against the DNABII protein integration host factor (IHF) inhibit sinus implant biofilms
Authors: Martyn Lauren , Sethia Rishabh , Chon Rachel , Novotny Laura , Goodman Steven D. , Elmaraghy Charles , Bakaletz Lauren O. 
Published: July 2019

ObjectivesChronic rhinosinusitis is a common, costly condition often treated with endoscopic sinus surgery and intraoperative placement of intranasal sinus implant materials. Whereas these materials aid in postoperative healing, they also support bacterial biofilm formation and thus contribute to negative outcomes. This study examined pretreatment of sinus implant materials with antibody against an essential bacterial biofilm structural component, the DNABII family of DNA‐binding proteins, as a strategy to prevent biofilm formation.MethodsSinus implant materials were equilibrated in immunoglobulin G (IgG)‐enriched antiserum against the DNABII protein integration host factor (IHF), individually or in combination with amoxicillin‐clavulanate prior to inoculation with nontypeable Haemophilus influenzae (NTHI), a predominant pathogen of chronic rhinosinusitis. After 16 hours, the bacterial burden was quantitated and compared to pretreatment with saline, IgG‐enriched naive serum, or amoxicillin‐clavulanate alone.ResultsNTHI readily formed biofilms on all three materials in vitro. However, pretreatment of each material with IgG‐enriched anti‐IHF resulted in a significant decrease in bacterial burden compared to controls (P ≤ 0.05). Moreover, a significant and synergistic outcome was achieved with a cocktail of anti‐IHF plus amoxicillin‐clavulanate (P ≤ 0.05) with complete inhibition of NTHI biofilm formation on all three materials.ConclusionsBiofilm formation was well supported in vitro on three sinus implant materials that vary in composition and resorption characteristics; however, pretreatment of each with DNABII protein targeted antibodies in combination with a previously ineffective antibiotic was highly effective to prevent the formation NTHI biofilms. These data demonstrate the potential for clinical utility of pretreatment of sinus implant and additional surgical materials with anti‐DNABII antibodies.Level of EvidenceNA Laryngoscope, 130:1364–1371, 2020