bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concurrent Implantation of Intra‐Aortic Balloon Pump and Extracorporeal Membrane Oxygenation Improved Survival of Patients With Postcardiotomy Cardiogenic Shock
Authors: Chen Kai , Hou Jianfeng , Tang Hanwei , Hu Shengshou 
Published: October 2018

AbstractThe aim of this study is to report the combined application of extracorporeal membrane oxygenation (ECMO) with intra‐aortic balloon pumping (IABP) in postcardiotomy cardiac shock (PCS). A total of 60 consecutive patients who received both ECMO and IABP (concomitantly 24 hours) for PCS from February 2006 to March 2017 at Fuwai Hospital were included in our study. Clinical characteristics of the patients were collected retrospectively and compared between survivors and non‐survivors. Logistic regression analysis was used as predictors for survival to discharge. The study cohort had a mean age of 51.4±12.7 years with 75% males. ECMO was implanted intra‐operatively in 38 (63%) patients and post‐operatively in 22 (37%) patients. ECMO was implanted concurrently with IABP in 38 (63%) patients. Heart transplantation (38%) and coronary artery bypass graft (33%) were the main surgical procedures. ECMO was weaned successfully in 48% patients, and the rate of survival to discharge was 43%. Survivors showed less bedside ECMO implantation (12% vs. 41%, P=0.012) and more concurrent implantation of ECMO with IABP (81% vs. 50%, P=0.014). Concurrent implantation of IABP with ECMO (OR=0.177, P=0.015, 95% CI: 0.044‐0.718) was an independent predictor of survival to discharge. As for complications, the rate of renal failure (59% vs. 15%, P=0.001) and multiple organ dysfunction syndrome (29% vs. 0, P=0.003) was higher in patients who failed to survive to discharge. Patients who had heart transplantation had a better long‐term survival than others (P=0.0358). In summary, concurrent implantation of ECMO with IABP provides better short‐term outcome for PCS and combined application of ECMO with IABP for PCS after heart transplantation had a favorable long‐term outcome.
The cost‐effectiveness of alternative vision screening models among preschool children in rural China
Authors: Wang Lei , Congdon Nathan , Hogg Ruth E. , Zhang Siqi , Li Mengjie , Shi Yaojiang , Jin Ling , He Fei , Wang Huan , Boswell Matthew , Iyer Mony 
Published: October 2018

AbstractPurposeTo explore the accuracy and cost‐effectiveness of three vision screening models among preschool children in rural China.MethodsVision screening was carried out among children aged 4–5 years in 65 preschools in two counties in Northwest China, using Crowded Single Lea Symbols to test visual acuity. Children were assigned randomly by school to one of three screening models: screening by teachers (15 schools, 1835 children), local optometrists (30 schools, 1718 children) or volunteers (20 schools, 2183 children). Children identifying ≥2 symbols incorrectly in either eye failed screening. Accuracy of screening was compared with screenings executed by experienced optometrists among 141 children selected randomly from the three screening models. Direct and indirect costs for each model were assessed. Costs to detect a true case failed screening were estimated.ResultsThe sensitivity for three models ranged from 76.9% to 87.5%, specificity from 84.9% to 86.7% and standardized positive predictive value from 83.7% to 85.7%. None differed significantly between models. The costs per case detected were $37.53, $59.14 and $52.19 for the teachers, local optometrists and volunteers. In producing the cost estimates for teacher screening and local optometrist screening models, we used a salary payment that was identical for both models (with the salary being equal to that of the optometrist). The teacher screening model was the most cost‐effective.ConclusionAccuracy of screening by teachers, local optometrists and volunteers was the same in this setting, but the use of teachers was most cost‐effective, reducing the cost per case detected by almost 40%.
Unravelling the suboptimal response of TP53‐mutated chronic lymphocytic leukaemia to ibrutinib
Authors: Guarini Anna , Peragine Nadia , Messina Monica , Marinelli Marilisa , Ilari Caterina , Cafforio Luciana , Raponi Sara , Bonina Silvia , Mariglia Paola , Mauro Francesca R. , Gaidano Gianluca , Del Giudice Ilaria , Foà Robin 
Published: October 2018

SummaryTP53‐disrupted chronic lymphocytic leukaemia (CLL) patients show a suboptimal long‐term response to ibrutinib. We hereby report that ibrutinib‐induced in vitro apoptosis and proliferation inhibition were significantly lower in TP53‐mutated (TP53‐M) CLL cells compared to TP53 wild‐type cells. Contrariwise, venetoclax effectively killed TP53‐M cells. Gene expression profile analysis of TP53‐M cells revealed a downmodulation of B‐cell receptor (BCR)‐related genes and an upmodulation of genes with anti‐apoptotic/pro‐survival activity, suggesting that the survival and proliferation of TP53‐M cells are less dependent on the BCR pathway. These observations further support the use of drug combinations for the optimal management of TP53‐M CLL patients.
Sight‐threatening Graves’ orbitopathy: Twenty years’ experience of a multidisciplinary thyroid‐eye outpatient clinic
Authors: Tramunt Blandine , Imbert Philippe , Grunenwald Solange , Boutault Franck , Caron Philippe 
Published: October 2018

SummaryContextSight‐threatening Graves’ orbitopathy affects 3% to 5% of patients with Graves’ orbitopathy.ObjectivesTo describe the management of patients with sight‐threatening Graves’ orbitopathy seen in a multidisciplinary thyroid‐eye outpatient clinic dedicated to Graves’ orbitopathy (GO).Patients and methodsWe enrolled all patients with sight‐threatening GO (dysthyroid optic neuropathy and corneal ulcer as defined in the EUGOGO statement) seen and treated in our GO multidisciplinary thyroid‐eye outpatient clinic over the last two decades.ResultsA total of 31 patients (median age 51 years old) including 24 women (77%) and 58% active smokers. This population represented 47 cases (case = eye) of sight‐threatening GO. Dysthyroid optic neuropathy (DON) occurred in 40 eyes, corneal ulcer in 15 eyes and both in 8. At presentation, the clinical features of DON were reduced visual acuity (85%), visual field defects (80%), optic disc swelling (42%) and reduced colour vision (100%). At one year, surgical orbital decompression (OD) was performed in 82.5% of DON cases. Only seven eyes with DON were treated with pulses of intra‐venous glucocorticoids. For 10 patients, several therapeutic strategies (OD n = 4, punctal plug n = 1, amniotic membrane graft n = 2, tarsorrhaphy n = 2, botulinum toxin injection = 3 and eyelid surgery n = 2) were used to treat corneal ulcer. For each ophthalmological parameter, more than 85% of DON cases had recovery or improvement after treatment. For visual acuity in corneal ulcer, it was 71.4%.ConclusionWe report 47 cases of sight‐threatening GO. Orbital decompression was performed in the majority of DON cases and several therapeutic strategies were necessary to treat corneal ulcer. The results are satisfactory in sight‐threatening Graves’ orbitopathy due to multidisciplinary management.
Loss of GINS2 inhibits cell proliferation and tumorigenesis in human gliomas
Authors: Shen Yun‐Long , Li He‐Zhen , Hu Yan‐Wei , Zheng Lei , Wang Qian 
Published: October 2018

SummaryAimsIn this study, we examined the expression of GINS2 in glioma and determined its role in glioma development.MethodsThe protein expression of GINS2 was assessed in 120 human glioma samples via immunohistochemistry. Then, we suppressed the expression of GINS2 in glioma cell strains U87 and U251 using a short hairpin RNA lentiviral vector. In addition, RNA sequencing and bioinformatics analysis were performed on glioma cells before and after GINS2 knockdown. Subsequent co‐immunoprecipitation and western blot experiments indicated possible downstream regulatory molecules.ResultsThe present results showed that GINS2 can accelerate the growth of glioma cells, whereas the suppression of GINS2 expression decreased the proliferation and tumorigenicity of glioma cells. Mechanism research experiments proved that GINS2 can block the cell cycle by regulating certain downstream molecules, such as MCM2, ATM, and CHEK2.ConclusionGINS2 is closely related to the occurrence and development of glioma, and is likely to become a prognostic marker for glioma patients, as well as a potential therapeutic target in the treatment of glioma.
H19 regulation of oestrogen induction of symmetric division is achieved by antagonizing Let‐7c in breast cancer stem‐like cells
Authors: Wang Meng , Li Yuan , Xiao Guo‐Dong , Zheng Xiao‐Qiang , Wang Ji‐Chang , Xu Chong‐Wen , Qin Sida , Ren Hong , Tang Shou‐Ching , Sun Xin 
Published: October 2018

AbstractObjectivesBreast cancer stem‐like cells (BrCSCs) are the major reason for tumour generation, resistance and recurrence. The turbulence of their self‐renewal ability could help to constrain the stem cell expansion. The way BrCSCs divided was related to their self‐renewal capacity, and the symmetric division contributed to a higher ability. Non‐coding long RNA of H19 was involved in multiple malignant procedures; the role and mechanistic proof of non‐coding long RNA of H19 in controlling the divisions of BrCSCs were barely known.Materials and MethodsIndicative functions of H19 in preclinical study were analysed by using the TCGA data base. Division manners were defined by using fluorescence staining.ResultsWe identified the stimulation of H19 on symmetric division of BrCSCs, which subsequently resulted in self‐renewing increasing. H19 inhibited the Let‐7c availability by acting as its specific molecular sponge, and with Let‐7c inhibition, oestrogen receptor activated Wnt signalling was unconstrained. Similarly, restoring Let‐7c constrained oestrogen receptor activated Wnt factors, which sequentially inhibited the H19 decreasing of Let‐7 bioavailability. Let‐7c is reactivated in vitro where H19 was knockdown, and later inhibited the symmetric division of BrCSCs. Reciprocally, Wnt pathway activation leads to H19 increasing, which in turn decreased Let‐7c bioavailability.ConclusionsOur results revealed a previously undescribed double negative feedback loop between sponge H19 and targeted Let‐7c through oestrogen activated Wnt signalling that dominated in stem cells’ division.
Pedunculopontine tegmentum cholinergic loss leads to a progressive decline in motor abilities and neuropathological changes resembling progressive supranuclear palsy
Authors: MacLaren Duncan A.A. , Ljungberg Trisha L. , Griffin Meghan E. , Clark Stewart D. 
Published: October 2018

AbstractProgressive supranuclear palsy (PSP) is the most common atypical Parkinsonism. Although PSP shares some symptomology with Parkinson's disease (PD), PSP has a different underlying pathology characterized by tau aggregation. Furthermore, PSP sufferers respond poorly to PD medications and there are no effective alternative therapeutics. The development of both palliative and disease altering therapeutics has been hampered by the lack of an animal model that displays relevant PSP‐like pathology and behavioral deficits. Previously, our lab found that in rats the selective removal of cholinergic pedunculopontine neurons (whose axonal projections overlap with areas of PSP pathology), mimics the extensive loss of cholinergic pedunculopontine neurons seen in PSP, and produces a unique PSP‐like combination of deficits in: startle reflex, attention, and motor function. The present study extends those findings by allowing the lesion to incubate for over a year and compares behavioral and post‐mortem pathology of pedunculopontine‐cholinergic‐lesioned and sham‐lesioned rats. There was an early startle reflex deficit which did not improve over time. Progressive declines in motor function developed over the course of the year, including an increase in the number of “slips” while navigating various beams and poorly coordinated transitions from an elevated platform into homecages. Histological analysis discovered that the loss off cholinergic pedunculopontine neurons precipitated a significant loss of substantia nigra tyrosine hydroxylase‐positive neurons and a significant enlargement of the lateral ventricles. The latter is a distinguishing feature between PSP and PD. This preclinical animal model of PSP has the potential to further our understanding of PSP and aid in the testing of potential therapeutic agents.
Task errors contribute to implicit aftereffects in sensorimotor adaptation
Authors: Leow Li‐Ann , Marinovic Welber , de Rugy Aymar , Carroll Timothy J. 
Published: October 2018

AbstractPerturbations of sensory feedback evoke sensory prediction errors (discrepancies between predicted and actual sensory outcomes of movements), and reward prediction errors (discrepancies between predicted rewards and actual rewards). When our task is to hit a target, we expect to succeed in hitting the target, and so we experience a reward prediction error if the perturbation causes us to miss it. These discrepancies between intended task outcomes and actual task outcomes, termed “task errors,” are thought to drive the use of strategic processes to restore success, although their role is incompletely understood. Here, as participants adapted to a 30° rotation of cursor feedback representing hand position, we investigated the role of task errors in sensorimotor adaptation: during target‐reaching, we either removed task errors by moving the target mid‐movement to align with cursor feedback of hand position, or enforced task error by moving the target away from the cursor feedback of hand position, by 20–30° randomly (clockwise in half the trials, counterclockwise in half the trials). Removing task errors not only reduced the extent of adaptation during exposure to the perturbation, but also reduced the amount of post‐adaptation aftereffects that persisted despite explicit knowledge of the perturbation removal. Hence, task errors contribute to implicit adaptation resulting from sensory prediction errors. This suggests that the system which predicts the sensory consequences of actions via exposure to sensory prediction errors is also sensitive to reward prediction errors.
Effect of interannual precipitation variability on dryland productivity: A global synthesis
Authors: Gherardi Laureano A. , Sala Osvaldo E. 
Published: October 2018

AbstractClimate‐change assessments project increasing precipitation variability through increased frequency of extreme events. However, the effects of interannual precipitation variance per se on ecosystem functioning have been largely understudied. Here, we report on the effects of interannual precipitation variability on the primary production of global drylands, which include deserts, steppes, shrublands, grasslands, and prairies and cover about 40% of the terrestrial earth surface. We used a global database that has 43 datasets, which are uniformly distributed in parameter space and each has at least 10 years of data. We found (a) that at the global scale, precipitation variability has a negative effect on aboveground net primary production. (b) Expected increases in interannual precipitation variability for the year 2,100 may result in a decrease of up to 12% of the global terrestrial carbon sink. (c) The effect of precipitation interannual variability on dryland productivity changes from positive to negative along a precipitation gradient. Arid sites with mean precipitation under 300 mm/year responded positively to increases in precipitation variability, whereas sites with mean precipitation over 300 mm/year responded negatively. We propose three complementary mechanisms to explain this result: (a) concave‐up and concave‐down precipitation–production relationships in arid vs. humid systems, (b) shift in the distribution of water in the soil profile, and (c) altered frequency of positive and negative legacies. Our results demonstrated that enhanced precipitation variability will have direct impacts on global drylands that can potentially affect the future terrestrial carbon sink.
Pathways of mineral‐associated soil organic matter formation: Integrating the role of plant carbon source, chemistry, and point of entry
Authors: Sokol Noah W. , Sanderman Jonathan , Bradford Mark A. 
Published: October 2018

AbstractTo predict the behavior of the terrestrial carbon cycle, it is critical to understand the source, formation pathway, and chemical composition of soil organic matter (SOM). There is emerging consensus that slow‐cycling SOM generally consists of relatively low molecular weight organic carbon substrates that enter the mineral soil as dissolved organic matter and associate with mineral surfaces (referred to as “mineral‐associated OM,” or MAOM). However, much debate and contradictory evidence persist around: (a) whether the organic C substrates within the MAOM pool primarily originate from aboveground vs. belowground plant sources and (b) whether C substrates directly sorb to mineral surfaces or undergo microbial transformation prior to their incorporation into MAOM. Here, we attempt to reconcile disparate views on the formation of MAOM by proposing a spatially explicit set of processes that link plant C source with MAOM formation pathway. Specifically, because belowground vs. aboveground sources of plant C enter spatially distinct regions of the mineral soil, we propose that fine‐scale differences in microbial abundance should determine the probability of substrate–microbe vs. substrate–mineral interaction. Thus, formation of MAOM in areas of high microbial density (e.g., the rhizosphere and other microbial hotspots) should primarily occur through an in vivo microbial turnover pathway and favor C substrates that are first biosynthesized with high microbial carbon‐use efficiency prior to incorporation in the MAOM pool. In contrast, in areas of low microbial density (e.g., certain regions of the bulk soil), MAOM formation should primarily occur through the direct sorption of intact or partially oxidized plant compounds to uncolonized mineral surfaces, minimizing the importance of carbon‐use efficiency, and favoring C substrates with strong “sorptive affinity.” Through this framework, we thus describe how the primacy of biotic vs. abiotic controls on MAOM dynamics is not mutually exclusive, but rather spatially dictated. Such an understanding may be integral to more accurately modeling soil organic matter dynamics across different spatial scales.
Natural forests exhibit higher carbon sequestration and lower water consumption than planted forests in China
Authors: Yu Zhen , Liu Shirong , Wang Jingxin , Wei Xiaohua , Schuler Jamie , Sun Pengsen , Harper Richard , Zegre Nicolas 
Published: October 2018

AbstractLarge‐scale planted forests (PF) have been given a higher priority in China for improving the environment and mitigating climate change relative to natural forests (NF). However, the ecological consequences of these PF on water resource security have been less considered in the national scale. Moreover, a critically needed comparison on key ecological effects between PF and NF under climate change has rarely been conducted. Here, we compare carbon sequestration and water consumption in PF and NF across China using combination of remote sensing and field inventory. We found that, on average, NF consumed 6.8% (37.5 mm per growing season) less water but sequestered 1.1% (12.5 g C m−2 growing season−1) more carbon than PF in the period of 2000–2012. While there was no significant difference in water consumption (p = 0.6) between PF and NF in energy‐limited areas (dryness index [DI] < 1), water consumption was significantly (p < 0.001) higher in PF than that in NF in water‐limited regions (DI > 1). Moreover, a distinct and larger shift of water yield was identified in PF than in NF from the 1980s to the 2000s, indicating that PF were more sensitive to climate change, leading to a higher water consumption when compared with NF. Our results suggest NF should be properly valued in terms of maximizing the benefits of carbon sequestration and water yield. Future forest plantation projects should be planned with caution, particularly in water‐limited regions where they might have less positive effect on carbon sequestration but lead to significant water yield reduction.
The persistence of inter‐regional hierarchy in technology transfer networks: An analysis of Chinese patent licensing data
Authors: Seo Ilwon , Sonn Jung Won 
Published: October 2018

AbstractThis paper asks whether the technological development of a nation reduces the inter‐regional hierarchy in knowledge flow. We examine two scenarios that are the alternative to each other. The first is what we call the globalization of regional innovation system/weakening of inter‐regional hierarchy scenario: As many regions develop their niches in the global economy, the national “anchor” region loses its relative importance as the importer and distributor of new knowledge, rendering the domestic inter‐regional hierarchy less significant as a result. The second scenario is the globalization of national innovation system/persistence of inter‐regional hierarchy. The nation’s traditional anchor region becomes even more active in importing technology and distributing it to other regions of the country. To test which scenario is closer to reality, we employ social network metrics to analyse inter‐regional technology diffusion networks using Chinese patent licensing data for the 1998–2013 period. Our findings support the second scenario, showing that the influence of the traditional anchor region persists in the hierarchical network structure as new cities enter the network. We found five anchor regions: the three usual suspects—Beijing, Shanghai and Shenzhen—plus two that were slightly less expected—Dongguan and Suzhou.
Can the indicators of chronic ethanol consumption be minimized by a continuous flaxseed intake?
Authors: Latini Juliana Tomaz Pacheco , Vicente Gabriela Câmara , Velarde Luis Guillermo Coca , Benedicto Hildebrando Gomes , de Castro Resende Ângela , Teixeira Michelle Teixeira , de Almeida Kátia Calvi Lenzi , Boaventura Gilson Teles 
Published: October 2018

SummaryThe aim of this study was to evaluate the use of flaxseed in animals subjected to ethanol‐induced hepatotoxicity. Twenty‐four male rats were divided into four groups (n = 6): control group (CG) which received a control diet and water ad libitum; flaxseed group (FG) which received control diet with an addition of 25% flaxseed flour and water ad libitum; ethanol control group (ECG) which received control diet and a solution of 10% ethanol (v/v) as the only liquid source; and ethanol flaxseed group (EFG) which received control diet with an addition of 25% flaxseed flour and a solution of 10% ethanol (v/v) as the only liquid source. The animals were euthanized at 60 days, when blood was collected for biochemical analysis and liver was collected for histomorphometric analysis. Rats fed with diets containing flaxseed showed lower values of alkaline phosphatase (P = 0.020) and lower concentration of total bilirubin (P = 0.006), direct bilirubin (P = 0.013) and indirect bilirubin (P = 0.018) compared to ECG and EFG. The groups receiving flaxseed diets demonstrated higher expression of superoxide dismutase (SOD) enzyme (P < 0.001) than CG and ECG but did not affect thiobarbituric acid (TBARS) expression (P = 0.055). Regarding liver analysis, the ECG and EFG showed larger hepatocyte nuclei and paler cytoplasm than the groups who had not received ethanol, and less in fluid accumulation (oedema) in the cytoplasm than was seen in the FG and EFG livers. These latter two groups showed fewer fatty cells than was seen in the groups that had not been given flaxseed, so that the diagnosis of hepatic steatosis was not justified. In conclusion, therefore, this study showed that the indicators of ethanol chronic consumption can be reduced by the introduction of continuous flaxseed dietary intake.