bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the effect of hypoxia on cardiac metabolism using hyperpolarized 13C magnetic resonance spectroscopy
Authors: Le Page Lydia M. , Rider Oliver J. , Lewis Andrew J. , Noden Victoria , Kerr Matthew , Giles Lucia , Ambrose Lucy J.A. , Ball Vicky , Mansor Latt , Heather Lisa C. , Tyler Damian J. 
Published: May 2019

Hypoxia plays a role in many diseases and can have a wide range of effects on cardiac metabolism depending on the extent of the hypoxic insult. Noninvasive imaging methods could shed valuable light on the metabolic effects of hypoxia on the heart in vivo. Hyperpolarized carbon‐13 magnetic resonance spectroscopy (HP 13C MRS) in particular is an exciting technique for imaging metabolism that could provide such information.The aim of our work was, therefore, to establish whether hyperpolarized 13C MRS can be used to assess the in vivo heart's metabolism of pyruvate in response to systemic acute and chronic hypoxic exposure.Groups of healthy male Wistar rats were exposed to either acute (30 minutes), 1 week or 3 weeks of hypoxia. In vivo MRS of hyperpolarized [1‐13C] pyruvate was carried out along with assessments of physiological parameters and ejection fraction. Hematocrit was elevated after 1 week and 3 weeks of hypoxia.30 minutes of hypoxia resulted in a significant reduction in pyruvate dehydrogenase (PDH) flux, whereas 1 or 3 weeks of hypoxia resulted in a PDH flux that was not different to normoxic animals. Conversion of hyperpolarized [1‐13C] pyruvate into [1‐13C] lactate was elevated following acute hypoxia, suggestive of enhanced anaerobic glycolysis. Elevated HP pyruvate to lactate conversion was also seen at the one week timepoint, in concert with an increase in lactate dehydrogenase (LDH) expression. Following three weeks of hypoxic exposure, cardiac metabolism of pyruvate was comparable with that observed in normoxia.We have successfully visualized the effects of systemic hypoxia on cardiac metabolism of pyruvate using hyperpolarized 13C MRS, with differences observed following 30 minutes and 1 week of hypoxia. This demonstrates the potential of in vivo hyperpolarized 13C MRS data for assessing the cardiometabolic effects of hypoxia in disease.
Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer‐associated fibroblasts
Authors: Hegab Ahmed E , Ozaki Mari , Kameyama Naofumi , Gao Jingtao , Kagawa Shizuko , Yasuda Hiroyuki , Soejima Kenzo , Yin Yongjun , Guzy Robert D , Nakamura Yoshikazu , Ornitz David M , Betsuyaku Tomoko 
Published: May 2019

AbstractCancer‐associated fibroblasts (CAFs) are known to promote tumourigenesis through various mechanisms. Fibroblast growth factor (FGF)/FGF receptor (FGFR)‐dependent lung cancers have been described. We have developed a mouse model of lung adenocarcinoma that was constructed through the induction of Fgf9 overexpression in type 2 alveolar cells. The expression of Fgf9 in adult lungs resulted in the rapid development of multiple adenocarcinoma‐like tumour nodules. Here, we have characterised the contribution of CAFs and the Fgf/Fgfr signalling pathway in maintaining the lung tumours initiated by Fgf9 overexpression. We found that CAF‐secreted Fgf2 contributes to tumour cell growth. CAFs overexpressed Tgfb, Mmp7, Fgf9, and Fgf2; synthesised more collagen, and secreted inflammatory cell‐recruiting cytokines. CAFs also enhanced the conversion of tumour‐associated macrophages (TAMs) to the tumour‐supportive M2 phenotype but did not influence angiogenesis. In vivo inhibition of Fgfrs during early lung tumour development resulted in significantly smaller and fewer tumour nodules, whereas inhibition in established lung tumours caused a significant reduction in tumour size and number. Fgfr inhibition also influenced tumour stromal cells, as it significantly abolished TAM recruitment and reduced tumour vascularity. However, the withdrawal of the inhibitor caused a significant recurrence/regrowth of Fgf/Fgfr‐independent lung tumours. These recurrent tumours did not possess a higher proliferative or propagative potential. Our results provide evidence that fibroblasts associated with the Fgf9‐induced lung adenocarcinoma provide multiple means of support to the tumour. Although the Fgfr blocker significantly suppressed the tumour and its stromal cells, it was not sufficient to completely eliminate the tumour, probably due to the emergence of alternative (resistance/maintenance) mechanism(s). This model represents an excellent tool to further study the complex interactions between CAFs, their related chemokines, and the progression of lung adenocarcinoma; it also provides further evidence to support the need for a combinatorial strategy to treat lung cancer. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
An accelerometry and observational study to quantify upper limb use after stroke during inpatient rehabilitation
Authors: Chin Lay Fong , Hayward Kathryn S. , Soh Aloysius Jun An , Tan Chin Mei , Wong Cheryl Jing Ru , Loh Jia Wei , Loke Genevieve Jia Hui , Brauer Sandra 
Published: May 2019

AbstractObjectivesThe objectives of the study are to characterize paretic upper limb (UL) use in people with different levels of impairment 4 weeks poststroke and to compare accelerometry and direct observational approaches.MethodsTwelve stroke inpatients (five mild, three moderate, and four severe UL impairment) were recruited from a rehabilitation hospital. UL use was measured using accelerometry (24 hr) and direct observation (12 hr of behavioural mapping). Accelerometry variables included duration of use, use ratio, magnitude ratio, bilateral magnitude, and variation ratio. Direct observation recorded the duration of use and type of UL movement (e.g., functional vs. non‐functional).ResultsFrom accelerometry data, people with mild, moderate, and severe UL impairments used their paretic UL 59%, 45%, and 22% of a 24 hr‐day, respectively. People with severe UL impairment had the lowest paretic UL use duration (median 1.49 hr/day), magnitude ratio, and variation ratio compared with people with mild and moderate UL impairment. From 12 hr of observational data, people with mild impairment were using their UL for 37.8% of the observed time, whereas the people with moderate and severe impairment were using their UL 15.8% and 4.9%, respectively. UL movements for the mild cohort were mainly functional, whereas UL movements of the moderate and severe cohorts were mainly non‐functional. UL movements were predominantly active for the mild and moderate cohorts but passive for the severe cohort. Duration of paretic UL use from accelerometry and observation data were highly correlated (ICC > 0.8), but the absolute percentage error between methods ranged from 34.2% to 42.7%.ConclusionsParetic UL use within the first 4 weeks poststroke differs across levels of impairment in this exploratory study. Accelerometry and observation findings of paretic UL use were correlated and may be needed in different situations as they capture different information.
SPOP and FOXA1 mutations are associated with PSA recurrence in ERG wt tumors, and SPOP downregulation with ERG‐rearranged prostate cancer
Authors: Hernández‐Llodrà Silvia , Segalés Laura , Safont Ainara , Juanpere Nuria , Lorenzo Marta , Fumadó Lluís , Rodríguez‐Vida Alejo , Cecchini Lluís , Bellmunt Joaquim , Lloreta‐Trull Josep 
Published: May 2019

AbstractBackgroundERG fusion‐related prostate cancer (PrCa) is the most prevalent oncogenic driver subclass. SPOP, FOXA1, and IDH1 mutations are other three main oncogenic driver subclasses in non–ETS‐fusion PrCa. ERG protein levels seem to be increased in SPOP‐mutated cases, and different studies reported that SPOP mutations and ERG fusions are mutually exclusive. The aim of this study has been to analyze the alterations in non–ETS‐oncogenic drivers in PrCa.MethodsSPOP, FOXA1, and IDH mutations were investigated by polymerase chain reaction (PCR) and Sanger direct sequencing. ERG, SPOP, and TMPRSS2‐ERG messenger RNA expression was assessed by quantitative real‐time PCR from complementary DNA, and the presence of the fusion was also analyzed by nonquantitative PCR. The clinical pathological features were retrieved from the charts of the 111 patients included in the study (MARBiobanc, Barcelona, Spain).ResultsLoss of SPOP expression (25.2%) was associated with ERG overexpression (P = 0.0036). SPOP mutations were found in 5.4% cases, all with wild‐type (wt) ERG (P = 0.007). FOXA1 mutations were found in 8.2% cases, most of them ERG wt (P = 0.06). No IDH1 mutations were found. SPOP or FOXA1 mutations were found in 1.7% of ERG‐rearranged, and 34.2% of non–ERG‐rearranged cases (P < 0.0001). SPOP or FOXA1 alterations (mutations or expression loss) were significantly more common in GG5, while isolated ERG overexpression was more common in GG1 tumors (P = 0.042). SPOP‐or FOXA1‐mutated cases were associated with a shorter time to prostate‐specific antigen (PSA) recurrence in the univariate (P = 0.0009), and with the PSA recurrence risk in the multivariate (P = 0.023) analysis.ConclusionsIn conclusion, SPOP and FOXA1 mutations may have prognostic value in ERG wt tumors. Interestingly, in absence of SPOP mutations, downregulation of this gene is a feature of many ERG‐rearranged prostate tumors.
Continuous robust fault‐tolerant control and vibration suppression for flexible spacecraft without angular velocity
Authors: Zhang Xiuyun , Zong Qun , Tian Bailing , Liu Wenjing 
Published: May 2019

SummaryThe fault‐tolerant control and vibration suppression for flexible spacecraft without angular velocity measurement are investigated. External disturbances, actuator faults, unknown angular velocity, and flexible vibration are addressed simultaneously. Firstly, a model‐free adaptive supertwisting state observer and an angular velocity calculation algorithm in one step are developed by using attitude information only, which can estimate the angular velocity in finite time. Then, on the basis of angular velocity estimation, a novel continuous multivariable integral sliding mode (CMISM) is proposed for the first time, which is a combination of continuous nominal controller and a modified multivariable twisting controller to reject disturbances and faults. The CMISM can stabilize attitudes in finite time and attenuate chattering effectively. Furthermore, the input shaping technique is developed to achieve effective vibration suppression of the flexible appendages. Finally, the efficiency of the proposed method is illustrated by numerical simulations.
VLSI-SoC: An Enduring Tradition
Authors: Reis Ricardo , Glesner Manfred 
Published: May 2019

Abstract
VLSI-SoC series of conferences started in 1981 and this chapter presents a little bit of its history. Since the beginning, the conference moves around the world, showing recent works in the field of VLSI and Systems-on-Chip design and design automation. The contents of books related to the set of event editions is in some way a witness of the extraordinary evolution of the field in these almost 4 decades.
Fracture resistance and marginal gap formation of post-core restorations: influence of different fiber-reinforced composites
Authors: Fráter Márk , Lassila Lippo , Braunitzer Gábor , Vallittu Pekka K. , Garoushi Sufyan 
Published: May 2019

Abstract
Objectives
The aim was to explore the fracture behavior and marginal gap within the root canal of endodontically treated (ET) premolars restored with different fiber-reinforced post-core composites (FRCs). Further aim was to evaluate the composite curing at different depths in the canal.

Materials and methods
Eighty-seven intact upper premolars were collected and randomly divided into six groups. After endodontic procedure, standard MOD cavities were prepared and restored with their respective fiber-reinforced post-core materials: group 1: prefabricated unidirectional FRC-post + conventional composite core; group 2: prefabricated unidirectional FRC-post + short fiber composite (SFRC) core; group 3: individually formed unidirectional FRC-post + conventional composite core; group 4: randomly oriented SFRC directly layered as post and core; group 5: individually formed unidirectional FRC + randomly oriented SFRC as post and core. After restorations were completed, teeth (n = 3/group) were sectioned and then stained. Specimens were viewed under a stereo microscope and the percentage of microgaps within the root canal was calculated. Fracture load was measured using universal testing machine.

Results
SFRC application in the root canal (groups 4 and 5) showed significantly higher fracture load (876.7 N) compared to the other tested groups (512–613 N) (p < 0.05). Post/core restorations made from prefabricated FRC-post (group 1) exhibited the highest number of microgaps (35.1%) at the examined interphase in the root canal.

Conclusions
The restoration of ET premolars with the use of SFRC as post-core material displayed promising performance in matter of microgap and load-bearing capacity.

Clinical significance
Fracture resistance of ET premolar restored by bilayered composite restoration that includes both SFRC as post-core material and surface conventional resin seems to be beneficial.
When parents are inconsistent: Parenting style and adolescents' involvement in cyberbullying
Authors: Katz Idit , Lemish Dafna , Cohen Rinat , Arden Adi 
Published: May 2019

ABSTRACTIntroductionThe prevalence of cyberbullying among adolescents is globally on the rise. This study examined how general and cyber‐specific parenting styles impact the prevalence of young adolescents' involvement in cyberbullying as victims and/or perpetrators.MethodsOne hundred and eighty 7th and 8th‐grade Israeli students participated (Mean age = 13.25, SD = 0.81; 86 males, 89 females, 5 did not indicate gender). Adolescents reported the frequency of their involvement in cyberbullying, and whether their parents were using “autonomy‐supportive” or “psychologically controlling” strategies generally and specifically when mediating internet use.ResultsA controlling parenting‐style as well as an inconsistent internet‐mediation style were associated with a higher prevalence of adolescent involvement in cyberbullying as victims and as perpetrators. Prevalence was higher when parents who generally use a controlling style were less controlling or consistent when mediating internet use.ConclusionDespite the caveats related to parental control, parents who generally use a controlling style should consistently use this style while mediating cyber. Inconsistent parenting style conveys messages concerning internet activities that contradict what teens are accustomed to receiving in other contexts. This inconsistency may encourage them to exploit their relative freedom in the cyber context and act irresponsibly.
Entangled security: Science, co-production, and intra-active insecurity
Authors: Elbe Stefan , Buckland-Merrett Gemma 
Published: May 2019

AbstractThis article advances a new account of security as an intensely relational and ontologically entangled phenomenon that does not exist prior to, nor independently of, its intra-action with other phenomena and agencies. Security's ‘entanglement’ is demonstrated through an analysis of the protracted security concerns engendered by ‘dangerous’ scientific experiments performed with lethal H5N1 flu viruses. Utilising methodological approaches recently developed in the field of Science and Technology Studies (STS), the article explicates the intensely ‘co-productive’ dynamics at play between security and science in those experiments, and which ultimately reveal security to be a deeply relational phenomenon continuously emerging out of its engagement with other agencies. Recovering this deeper ontological entanglement, the article argues, necessitates a different approach to the study of security that does not commence by fixing the meaning and boundaries of security in advance. Rather, such an approach needs to analyse the diverse sites, dynamics, and processes through which security and insecurity come to intra-actively materialise in international relations. It also demands a fundamental reconsideration of many of the discipline's most prominent security theories. They are not merely conceptual tools for studying security, but crucial participants in its intra-active materialisation.
High-repetition-rate, high-peak-power 1450 nm laser source based on optical parametric chirped pulse amplification
Authors: Wang Pengfei , Shao Beijie , Su Hongpeng , Lv Xinlin , Li Yanyan , Peng Yujie , Leng Yuxin 
Published: May 2019

We present a high-peak-power, near-infrared laser system based on optical parametric chirped pulse amplification pumped by a home-built picosecond pumping laser, which can generate over 40 mJ energy at 1450 nm center wavelength and operate at 100 Hz repetition rate. Subsequently, the chirped laser pulses are compressed down to 60 fs with 26.5 mJ energy, corresponding to a peak power of 0.44 TW. This high-energy, long-wavelength laser source is highly suitable for driving various nonlinear optical phenomena, such as high-order harmonic generation and high-flux coherent extreme ultraviolet/soft X-ray radiation.
#Ustoo: How I-O psychologists can extend the conversation on sexual harassment and sexual assault through workplace training
Authors: Medeiros Kelsey , Griffith Jennifer 
Published: May 2019

AbstractRecent events in the workplace, government, and college campuses in the US have brought the issues of sexual harassment and assault to the forefront of media and public discussion. Industrial and organizational (I-O) psychologists are uniquely suited to help address these issues by aiding in intervention development. Specifically, I-O psychologists can provide key insight regarding the context, design, development, and evaluation of sexual harassment and assault training efforts. Although some empirical evidence suggests that trainings are effective in the short term, there is little evidence to suggest long-term attitudinal or behavioral change outside of the training environment. Much of the research in this area, however, has focused solely on the training intervention, excluding the pre- and post-training environment. Thus, the present effort focuses on designing trainings that promote transfer, as well as improving measurement of desired outcomes, to provide a framework for improving sexual harassment and assault training. This framework addresses how individual differences, needs analysis, training design, evaluation, and post-training support contribute to lasting change while addressing the unique challenges associated with sexual harassment and assault. Last, this framework provides guidance for improving research in this area as well as practical suggestions for improving training programs.
Particle transport induced by internal wave beam streaming in lateral boundary layers
Authors: Horne E. , Beckebanze F. , Micard D. , Odier P. , Maas L. R. M. , Joubaud S. 
Published: May 2019

Quantifying the physical mechanisms responsible for the transport of sediments, nutrients and pollutants in the abyssal sea is a long-standing problem, with internal waves regularly invoked as the relevant mechanism for particle advection near the sea bottom. This study focuses on internal-wave-induced particle transport in the vicinity of (almost) vertical walls. We report a series of laboratory experiments revealing that particles sinking slowly through a monochromatic internal wave beam experience significant horizontal advection. Extending the theoretical analysis by Beckebanze et al. (J. Fluid Mech., vol. 841, 2018, pp. 614–635), we attribute the observed particle advection to a peculiar and previously unrecognized streaming mechanism in the stratified boundary layer originating at the lateral walls. This vertical boundary layer streaming mechanism is most efficient for significantly inclined wave beams, when vertical and horizontal velocity components are of comparable magnitude. We find good agreement between our theoretical prediction and experimental results.
GlacierMIP – A model intercomparison of global-scale glacier mass-balance models and projections
Authors: HOCK REGINE , BLISS ANDREW , MARZEION BEN , GIESEN RIANNE H. , HIRABAYASHI YUKIKO , HUSS MATTHIAS , RADIĆ VALENTINA , SLANGEN AIMÉE B. A. 
Published: May 2019

ABSTRACTGlobal-scale 21st-century glacier mass change projections from six published global glacier models are systematically compared as part of the Glacier Model Intercomparison Project. In total 214 projections of annual glacier mass and area forced by 25 General Circulation Models (GCMs) and four Representative Concentration Pathways (RCP) emission scenarios and aggregated into 19 glacier regions are considered. Global mass loss of all glaciers (outside the Antarctic and Greenland ice sheets) by 2100 relative to 2015 averaged over all model runs varies from 18 ± 7% (RCP2.6) to 36 ± 11% (RCP8.5) corresponding to 94 ± 25 and 200 ± 44 mm sea-level equivalent (SLE), respectively. Regional relative mass changes by 2100 correlate linearly with relative area changes. For RCP8.5 three models project global rates of mass loss (multi-GCM means) of >3 mm SLE per year towards the end of the century. Projections vary considerably between regions, and also among the glacier models. Global glacier mass changes per degree global air temperature rise tend to increase with more pronounced warming indicating that mass-balance sensitivities to temperature change are not constant. Differences in glacier mass projections among the models are attributed to differences in model physics, calibration and downscaling procedures, initial ice volumes and varying ensembles of forcing GCMs.
Dinoflagellates, Sporomorphs, and Other Palynomorphs from the Upper Pliocene St. Erth Beds of Cornwall, Southwestern England
Authors: Head Martin J. 
Published: May 2019

Palynological analysis of the highly fossiliferous marine clays of the St. Erth Beds of Cornwall has revealed the presence of dinoflagellates, acritarchs and prasinophytes, scolecodonts, microforaminiferal linings, freshwater? invertebrates, freshwater algal spores, embryophyte spores and pollen, fungal spores, and plant cuticles. These groups are documented here and several, including the dinoflagellates, are reported from the St. Erth Beds for the first time.The marine clays were deposited in warm, shallow waters of an inlet or embayment during a probable high stand in sea level. They are generally held to be of late Pliocene age, planktonic foraminiferal evidence placing them at between 1.9 and 2.1 Ma (late late Pliocene). Dinoflagellates are consistent with a late Pliocene age. Spores and pollen, if not reworked, suggest placement no higher than the lower part of the Tiglian Stage (upper Pliocene) of The Netherlands.Analysis of all palynological groups permits terrestrial and marine climates to be evaluated independently. The spore-pollen assemblage has some thermophilic elements but mainly reflects a cool-temperate terrestrial climate. In contrast, dinoflagellates—dominated by gymnodinialean? and protoperidinioid cysts—indicate warm inner neritic waters and present some evidence for subtropical to tropical conditions with winter sea-surface temperatures above 15°. Increased influence of the Gulf Stream during the late Pliocene, perhaps superimposed upon a phase of global warming, is hypothesized to explain these differentially elevated marine temperatures.The St. Erth inlet was not markedly brackish or hypersaline judging from the dinoflagellates, but rare freshwater algal spores attest either to some freshwater input or redeposition from sandy soils during marine incursion. High abundance of scolecodonts, about 1,500 to 2,000 per gram dry weight of sediment, allows speculation that the inlet hosted a thriving association of latest Pliocene marine annelid worms.A species of algae incertae sedis,Halodinium scopaeum, and three species of dinoflagellate,Algidasphaeridium?euaxum, Sumatradinium pliocenicum, andTrinovantedinium sterthense, are proposed as new. The dinoflagellate genusSelenopemphixBenedek, 1972, is emended herein.QuinquecuspisHarland, 1977, is now validated by the transfer ofTrinovantedinium concretumReid, 1978, toQuinquecuspisHarland, 1977, asQ. concretan. comb.