bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal‐Organic Frameworks for Hydrogen Energy Applications: Advances and Challenges
Authors: Bakuru Vasudeva Rao , DMello Marilyn Esclance , Kalidindi Suresh Babu 
Published: February 2019

AbstractHydrogen is in limelight as an environmental benign alternative to fossil fuels from few decades. To bring the concept of hydrogen economy from academic labs to real world certain challenges need to be addressed in the areas of hydrogen production, storage, and its use in fuel cells. Crystalline metal‐organic frameworks (MOFs) with unprecedented surface areas are considered as potential materials for addressing the challenges in each of these three areas. MOFs combine the diverse chemistry of molecular linkers with their ability to coordinate to metal ions and clusters. The unabated flurry of research using MOFs in the context of hydrogen energy related activities in the past decade demonstrates the versatility of this class of materials. In the present review, we discuss major strategical advances that have taken place in the field of “hydrogen economy and MOFs” and point out issues requiring further attention.
Measurement of C2 and CH temperatures in argon‐acetylene low‐pressure microwave‐induced plasma
Authors: Jovović J. , Majstorović G.Lj. 
Published: February 2019

The emission spectra of C2(d3Πg–a3Πu), CH(A2Δ–X2Π), and CH(B2Σ–X2Π) bands are analysed to measure rotational Trot, vibrational Tvib, and gas temperature Tg from Ar/C2H2 (5–20% C2H2) microwave‐induced plasma (MIP). In case when helium and hydrogen are used in the gas mixture instead of argon, no significant change in Trot is noticed. Both studied temperatures are insensitive in terms of the C2H2 percentage. From CH(0–0, A2Δ–X2Π) band R2 branch lines, two Trot (Trot ∼ 520–580 K for J′ = 3–9 and Trot ∼ 1,700–1,800 K for J′ = 10–17) are determined. The lower Trot equals the Tg (500–700 K) measured from C2 bands in this study. The H2 Fulcher‐α diagonal bands are recorded as well in the H2/C2H2 mixtures and Trot∼750–900 K of the H2 ground state measured. Tvib ∼ 6,000 K in Ar/C2H2 MIP is calculated from the integral intensity ratio of C2(2,1) and C2(3,2) bands.
AID‐based backoff for throughput enhancement in 802.11ah networks
Authors: Nabuuma Hanifa , Alsusa Emad , Baidas Mohammed W. 
Published: February 2019

SummaryIEEE 802.11ah is a WiFi standard developed to address requirements associated with the heterogeneous nature of the Internet of Things. It uses the sub‐1 GHz bands to enable long‐range transmissions for low‐power devices. However, long‐range coverage exacerbates the hidden node problem. To mitigate this problem, sectorization and grouping have been proposed by the standard. In this paper, hierarchical clustering and a modified Welsh‐Powell algorithm are combined to create hidden node‐free groups in a sectorized wireless local area network. An analytical model is developed for a deterministic backoff technique that uses association identifiers to set the backoff in order to eliminate collisions. The performance of the deterministic backoff technique is compared with that of existing schemes. Our results show that this approach results in higher throughput and lower latency than other deterministic backoff techniques.
Natural selection contributes to geographic patterns of thermal plasticity in Plantago lanceolata
Authors: Marshall Matthew M. , Batten Leslie C. , Remington David L. , Lacey Elizabeth P. 
Published: February 2019

AbstractA long‐standing debate in evolutionary biology concerns the relative importance of different evolutionary forces in explaining phenotypic diversification at large geographic scales. For example, natural selection is typically assumed to underlie divergence along environmental gradients. However, neutral evolutionary processes can produce similar patterns. We collected molecular genetic data from 14 European populations of Plantago lanceolata to test the contributions of natural selection versus neutral evolution to population divergence in temperature‐sensitive phenotypic plasticity of floral reflectance. In P. lanceolata, reflectance plasticity is positively correlated with latitude/altitude. We used population pairwise comparisons between neutral genetic differentiation (FST and Jost's D) and phenotypic differentiation (PST) to assess the contributions of geographic distance and environmental parameters of the reproductive season in driving population divergence. Data are consistent with selection having shaped large‐scale geographic patterns in thermal plasticity. The aggregate pattern of PST versus FST was consistent with divergent selection. FST explained thermal plasticity differences only when geographic distance was not included in the model. Differences in the extent of cool reproductive season temperatures, and not overall temperature variation, explained plasticity differences independent of distance. Results are consistent with the hypothesis that thermal plasticity is adaptive where growing seasons are shorter and cooler, that is, at high latitude/altitude.
New Aspects of Protein‐film Voltammetry of Redox Enzymes Coupled to Follow‐up Reversible Chemical Reaction in Square‐wave Voltammetry
Authors: Gulaboski Rubin , Janeva Milkica , Maksimova Viktorija 
Published: February 2019

AbstractProtein‐film square‐wave voltammetry of uniformly adsorbed molecules of redox lipophilic enzymes is applied to study their electrochemical properties, when a reversible follow‐up chemical reaction is coupled to the electrochemically generated product of enzyme's electrode reaction. Theoretical consideration of this so‐called “surface ECrev mechanism” under conditions of square‐wave voltammetry has revealed several new aspects, especially by enzymatic electrode reactions featuring fast electron transfer. We show that the rate of chemical removal/resupply of electrochemically generated Red(ads) enzymatic species, shows quite specific features to all current components of calculated square‐wave voltammograms and affects the electrode kinetics. The effects observed are specific for this particular redox mechanism (surface ECrev mechanism), and they got more pronounced at high electrode kinetics of enzymatic reaction. The features of phenomena of “split net‐SWV peak” and “quasireversible maximum”, which are typical for surface redox reactions studied in square‐wave voltammetry, are strongly affected by kinetics and thermodynamics of follow‐up chemical reaction. While we present plenty of relevant voltammetric situations useful for recognizing this particular mechanism in square‐wave voltammetry, we also propose a new approach to get access to kinetics and thermodynamics of follow‐up chemical reaction. Most of the results in this work throw new insight into the features of protein‐film systems that are coupled with chemical reactions.
Evolution of self‐perceived swallowing function, tongue strength and swallow‐related quality of life during radiotherapy in head and neck cancer patients
Authors: Van den Steen Leen , Van Gestel Dirk , Vanderveken Olivier , Vanderwegen Jan , Lazarus Cathy , Daisne Jean‐François , Van Laer Carl , Specenier Pol , Van Rompaey Diane , Mariën Steven , Lawson Georges , Chantrain Gilbert , Desuter Gauthier , Van den Weyngaert Danielle , Cvilic Sophie , Beauvois Sylvie , Allouche Johan , Delacroix Laurence , Vermorken Jan Baptist , Peeters Marc , Dragan Tatiana , Van de Heyning Paul , De Bodt Marc , Van Nuffelen Gwen 
Published: February 2019

AbstractBackgroundRadiation‐associated‐dysphagia is a serious side effect of radiotherapy (RT) for head and neck cancer (HNC).MethodsSeventy‐six patients had a weekly prospective follow‐up from baseline until one week post‐RT. Combined mixed model analysis (n = 43) determined the evolution of self‐perceived swallowing function, isometric tongue strength (MIP), tongue strength (TS) during swallowing (Pswal), and quality of life (QoL) in these patients during RT.ResultsSwallowing deteriorated from the third week on, resulting in an increase of tube dependency from 10% at baseline toward 31% post‐RT. Both MIP and Pswal are reduced, with anterior MIP decreasing in 29% of patients and posterior MIP in 17%. Pswal decreases for saliva and a bolus swallow. All QoL subscales except “sleep” were affected during RT.ConclusionsSelf‐perceived swallowing function, TS and QoL decrease during RT for HNC. Current findings highlight the need for early monitoring of these parameters.
Chronic in vivo optogenetic stimulation modulates neuronal excitability, spine morphology, and Hebbian plasticity in the mouse hippocampus
Authors: Moulin Thiago C. , Petiz Lyvia L. , Rayêe Danielle , Winne Jessica , Maia Roberto G. , Lima da Cruz Rafael V. , Amaral Olavo B. , Leão Richardson N. 
Published: February 2019

AbstractProlonged increases in excitation can trigger cell‐wide homeostatic responses in neurons, altering membrane channels, promoting morphological changes, and ultimately reducing synaptic weights. However, how synaptic downscaling interacts with classical forms of Hebbian plasticity is still unclear. In this study, we investigated whether chronic optogenetic stimulation of hippocampus CA1 pyramidal neurons in freely moving mice could (a) cause morphological changes reminiscent of homeostatic scaling, (b) modulate synaptic currents that might compensate for chronic excitation, and (c) lead to alterations in Hebbian plasticity. After 24 hr of stimulation with 15‐ms blue light pulses every 90 s, dendritic spine density and area were reduced in the CA1 region of mice expressing channelrhodopsin‐2 (ChR2) when compared to controls. This protocol also reduced the amplitude of mEPSCs for both the AMPA and NMDA components in ex vivo slices obtained from ChR2‐expressing mice immediately after the end of stimulation. Finally, chronic stimulation impaired the induction of LTP and facilitated that of LTD in these slices. Our results indicate that neuronal responses to prolonged network excitation can modulate subsequent Hebbian plasticity in the hippocampus.
Impacts of small cascaded hydropower plants on river discharge in a basin in Southern China
Authors: Xiao Xu , Chen Xiaohong , Zhang Lilan , Lai Rouyi , Liu Jie 
Published: February 2019

AbstractThe run‐off volume altered by the construction of hydropower plants affects ecohydrological processes in catchments. Although the impacts of large hydropower plants have been well documented in the literature, few studies have been conducted on the impacts of small cascaded hydropower plants (SCHPs). To evaluate the impacts of SCHPs on river flow, we chose a representative basin affected by hydropower projects and, to a lesser degree, by other human activities, that is, the Qiuxiang River basin in Southern China. The observed river discharge and climate data during the period of 1958–2016 were investigated. The datasets were divided into a low‐impact period and a high‐impact period based on the number of SCHPs and the capacities of the reservoirs. The daily river discharge alteration was assessed by applying the Indicators of Hydrologic Alteration. To separate the impact of the SCHPs on the local river discharge from that of climate‐related precipitation, the back‐propagation neural network was used to simulate the monthly average river discharge process. An abnormal result was found: Unlike large reservoirs in large watersheds, the SCHPs regulated the flows during the flood season but were not able to mitigate the droughts during the dry season due to their limited storage and the commonly occurring inappropriate interregulations of the SCHPs. The SCHPs also reduced the annual average river discharge in the research basin. The contribution of the SCHPs to the river discharge changes was 85.37%, much higher than the contributions of climate change (13.43%) and other human activities (1.20%). The results demonstrated that the impacts of the SCHPs were different from those of large dams and reservoirs that regulate floods and relieve droughts. It is necessary to raise the awareness of the impacts of these river barriers.
Effects of solvent used for fabrication on drug loading and release kinetics of electrosprayed temozolomide‐loaded PLGA microparticles for the treatment of glioblastoma
Authors: Rodriguez de Anda Daniel A. , Ohannesian Nareg , Martirosyan Karen S. , Chew Sue Anne 
Published: February 2019

AbstractGlioblastoma multiforme (GBM) is the most common and invasive form of malignant brain tumors and despite advances in surgery, radiotherapy, and chemotherapy, the survival of patients with GBM still remains poor. Temozolomide (TMZ) is the chemotherapy drug that is most commonly given orally after surgical resection of these tumors. In this study, the effects of solvents (i.e., dichloromethane and acetonitrile) used for the fabrication of electrosprayed TMZ‐loaded poly(lactic‐co‐glycolic acid) (PLGA) on drug loading, loading efficiency, drug release kinetics, surface morphology, and particle size were investigated. The results from this study demonstrated that by using a larger volume of a solvent with higher polarity (i.e., acetonitrile) which allows for a higher amount of hydrophilic TMZ to dissolve into the polymer solution, higher drug loading could be achieved. However, the particles fabricated with high amount of acetonitrile, which has a lower vapor pressure, had large pores and a smaller diameter which led to an initial burst release and high cumulative release at the end of the study. An optimal combination of the two solvents is needed to result in particles with a good amount of loading and minimal initial burst release. The electrosprayed microparticles were able to illicit a cytotoxic response in U‐87 MG glioblastoma cells at a lower concentration of drug compared to the free drug. This work indicated that electrospraying is a promising method for the fabrication of TMZ‐loaded PLGA microparticles for the treatment of GBM and solvent composition can be altered to control drug loading and release kinetics. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2317–2324, 2019.
Investigation of circular RNAs and related genes in pulmonary fibrosis based on bioinformatics analysis
Authors: Yang Liteng , Liu Xin , Zhang Ning , Chen Lifang , Xu Jingyi , Tang Wencheng 
Published: February 2019

AbstractPulmonary fibrosis is a lethal inflammatory disease. In this study, we aimed to explore the potential‐related circular RNAs (circRNAs) and genes that are associated with pulmonary fibrosis. Pulmonary fibrosis rat models were constructed and the fibrosis deposition was detected using hematoxylin and eosin and Masson staining. The differentially expressed circRNAs were obtained through RNA sequencing. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were further performed to uncover the key function and pathways in pulmonary fibrosis. The interaction networks between circRNAs and their downstream micro RNAs (miRNAs) and genes were constructed by Cytoscape Software. The quantitative polymerase chain reaction was performed to validate the expression of 10 candidate circRNAs and five of them were performed ringwise sequencing in pulmonary fibrosis rats. We further selected five candidate circRNAs target miRNAs and messenger RNAs and validated by real‐time polymerase chain reaction. The pulmonary fibrosis models were successfully constructed according to the pathological examination. circRNAs were differentially expressed between the pulmonary fibrosis and normal pulmonary tissues. GO analysis verified that the differentially expressed circRNAs were significantly clustered in the cellular component, molecular function, and biological process. In the KEGG analysis, circRNAs were enriched in the following pathways: antigen processing and presentation, phagosome, PI3K‐AKt signaling pathway, HTLV‐I infection, and Herpes simplex infection. After validation in pulmonary fibrosis rat models, it was found that five of those circRNAs (chr9:113534327|113546234 [down], chr1:200648164|200672411 [down], chr5:150850432|150865550 [up], chr20:14319170|14326640 [down], and chr10:57634023|57634588 [down]) showed a relatively consistent trend with predictions. Validation of these circRNAs target miRNAs and genes showed that chr9:113534327|113546234, chr20:14319170|14326640, and chr10:57634023|57634588 were implicated in Notch1 activated transforming growth factor‐β (TGF‐β) signaling pathway. The study demonstrated that a series of circRNAs are differentially expressed in pulmonary fibrosis rats. These circRNAs, especially TGF‐β‐ and Notch1‐related circRNAs might play an important role in regulating pulmonary fibrogenesis.
The process of change in psychotherapy with a pregnant patient following perinatal losses: An analysis of a case study
Authors: Cohen Keren , Leibovich Liat , Markin Rayna , Zilcha‐Mano Sigal 
Published: February 2019

AbstractAimDespite research suggesting increased anxiety and depressive symptoms after a perinatal loss and during future pregnancies, little knowledge exists to guide clinicians treating pregnant women after perinatal loss. This case study explores processes that facilitated therapeutic change for a pregnant patient with major depressive disorder (MDD) and posttraumatic stress disorder after perinatal losses.MethodThe study integrated quantitative and narrative analyses in a single case derived from the pilot phase of a randomized controlled trial on supportive‐expressive therapy for MDD.ResultsThe quantitative and narrative analyses suggest that an improvement in maladaptive interpersonal patterns toward the therapist, in the form of attachment avoidance, made it possible to form a strong alliance, which in turn led to a successful outcome.ConclusionsThe findings highlight the importance of improving maladaptive interpersonal patterns as a prerequisite to enable patients after pregnancy losses to develop and maintain a corrective therapeutic experience.
Construction of saliency map and hybrid set of features for efficient segmentation and classification of skin lesion
Authors: Khan Muhammad Attique , Akram Tallha , Sharif Muhammad , Saba Tanzila , Javed Kashif , Lali Ikram Ullah , Tanik Urcun John , Rehman Amjad 
Published: February 2019

AbstractSkin cancer is being a most deadly type of cancers which have grown extensively worldwide from the last decade. For an accurate detection and classification of melanoma, several measures should be considered which include, contrast stretching, irregularity measurement, selection of most optimal features, and so forth. A poor contrast of lesion affects the segmentation accuracy and also increases classification error. To overcome this problem, an efficient model for accurate border detection and classification is presented. The proposed model improves the segmentation accuracy in its preprocessing phase, utilizing contrast enhancement of lesion area compared to the background. The enhanced 2D blue channel is selected for the construction of saliency map, at the end of which threshold function produces the binary image. In addition, particle swarm optimization (PSO) based segmentation is also utilized for accurate border detection and refinement. Few selected features including shape, texture, local, and global are also extracted which are later selected based on genetic algorithm with an advantage of identifying the fittest chromosome. Finally, optimized features are later fed into the support vector machine (SVM) for classification. Comprehensive experiments have been carried out on three datasets named as PH2, ISBI2016, and ISIC (i.e., ISIC MSK‐1, ISIC MSK‐2, and ISIC UDA). The improved accuracy of 97.9, 99.1, 98.4, and 93.8%, respectively obtained for each dataset. The SVM outperforms on the selected dataset in terms of sensitivity, precision rate, accuracy, and FNR. Furthermore, the selection method outperforms and successfully removed the redundant features.
Orchestration of globally distributed knowledge within multinational companies network: A collaborative‐oriented view
Authors: Sajadirad Solmaz , Lassen Astrid Heidemann , Søberg Peder Veng 
Published: February 2019

This paper explores how the use of interfirm objects within different knowledge orchestration processes affects collaboration between headquarter and distributed subsidiaries. The discussion focuses on different approaches to knowledge orchestration based on combinations of the use of interfirm objects and the characteristics of knowledge orchestration processes. To this end, a conceptual framework is applied to 11 case studies from Danish industries.The findings suggest that adopting a collaborative‐oriented view of the use of interfirm objects facilitates orchestration of globally distributed knowledge in multinational companies. The findings also indicate that adoption of different knowledge orchestration approaches by companies can be influenced by headquarter–subsidiaries relationship, type of products, knowledge relevance between headquarter and subsidiaries, and level of headquarters' control over knowledge flow and subsidiaries' operation. Additionally, our findings propose that different approaches to knowledge orchestration can result in different degrees of innovation performance.This study extends existing literature on global knowledge management by focusing exclusively on knowledge orchestration in multinational companies. By introducing a dynamic view of the use of interfirm objects, facilitating collaboration between headquarters and subsidiaries, our findings would help multinational companies improve headquarter–subsidiaries relationship in favor of the efficiency and effectiveness of globally distributed network.
Materials and machining trends in terms of the existing axioms of the machining theory
Authors: Vasilko K. , Murčinková Z. , Nosáľ J. 
Published: February 2019

AbstractThe paper provides new insight into existing axioms of theory of machining. The existing theory of metalworking was based on the development of cutting materials during the 20th century. In particular, the improvement of cutting materials, the new special materials and progressive technologies and the trends to increase cutting speed call for a review of existing definitions and relations. Appling previously defined relations between cutting conditions and results of machining, the inaccuracies occur and this may lead to an incorrect choice of cutting conditions in the specific conditions of machining. The paper analyses existing well‐known equations used in practice and on the basis of extensive experimental analysis it modifies them. Furthermore, the paper concerns the evaluation of physical and technological parameters, such as chips compression, machined surface roughness, cutting forces, cutting tool‐wear and tool‐life.