bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Management of Diastasis Recti
Authors: Rosen Carly M. , Ngaage Ledibabari M. , Rada Erin M. , Slezak Sheri , Kavic Stephen , Rasko Yvonne 
Published: January 2019

Background
As elective surgery becomes more popular, the stringency of insurance coverage policies has increased exponentially. Many patients with diastasis recti (DR) are denied coverage of the corrective surgery that has been shown to improve function and quality of life in this patient population. Plastic surgeons are frustrated by the lack of guidelines and sparsity of coverage for surgical correction of DR.

Methods
Fifty-four US insurance companies and Medicare were reviewed to determine their policies of coverage. These policies were compared with the guidelines set forth by the American Society of Plastic surgery and current literature on DR.

Results
Insurance company policy for DR repair is not clear nor well established. Of the 55 policies reviewed in this study, 51 had an established policy. Forty of these companies would not cover abdominoplasty to repair DR under any circumstances. Eleven companies required preauthorization to ensure that the patient met the requirements of medical necessity. These requirements differed from company to company. A comprehensive list was compiled of details required for preauthorization.

Conclusions
Insurance company policies do not recognize the spectrum of patients with DR and the necessity of abdominoplasty to relieve symptoms of patients with severe debilitation. The current Common Procedural Terminology coding classifies abdominoplasty to repair DR solely as a cosmetic procedure. Policies for DR repair should be amended to include a functional procedure reimbursement for severe DR and include detailed guidelines for coverage requirements to simplify the reimbursement process.
Trichotillomania Triggered by Vitamin D Deficiency and Resolving Dramatically With Vitamin D Therapy
Authors: Akaltun İsmail 
Published: January 2019

Abstract
Trichotillomania (TTM) is a disorder characterized by the individual pulling out his hair in a repetitive manner, resulting in significant hair loss, a feeling of tension before the hair pulling, and pleasure during it. Our understanding of the neurobiological basis of TTM is limited. However, the condition in all likelihood involves multiple pathways and a complex interaction between various genetic, psychological, and social factors. Vitamin D deficiency is thought to be linked to rickets in children and to a range of different diseases in adults, including osteoporosis, osteomalacia, cardiovascular diseases, cancer, dermatological diseases, and psychiatric disorders. We report a case of a 4-year-old girl with TTM triggered by vitamin D deficiency resolving dramatically with vitamin D therapy.
Transient Compartmentalization dynamics in the presence of mutations and noise
Authors: Blokhuis Alex , Nghe Philippe , Peliti Luca , Lacoste David 
Published: January 2019

AbstractWe extend a recently introduced framework for transient compartmentalization of replicators with selection dynamics, by including the effect of mutations and noise in such systems. In the presence of mutations, functional replicators (ribozymes) are turned into non-functional ones (parasites). We evaluate the phase diagram of a system undergoing transient compartmentalization with selection. The system can exhibit either coexistence of ribozymes and parasites, or a pure parasite phase. If the mutation rate exceeds a certain level called the error threshold, the only stable phase is the pure parasite one. Transient compartmentalization with selection can relax this error treshold with respect to a bulk quasispecies case, and even allow ribozymes to coexist with faster growing parasites.In order to analyze the role of noise, we also introduce a model for the replication of a template by an enzyme. This model admits two regimes: a diffusion limited regime which generates a high noise, and a replication limited regime, which generates a low noise at the population level. Based on this model, we find that, since the ribozyme dynamics belongs to the replication limited regime, the effects of noise on the phase diagram of the system are mostly negligible. Our results underlines the importance of transient compartmentalization for prebiotic scenarios, and may have implications for directed evolution experiments.
Identification of potential new vaccine candidates in Salmonella typhi using reverse vaccinology and subtractive genomics-based approach
Authors: Mukherjee Sumit , Gangopadhyay Kaustav , Mukherjee Sunanda Biswas 
Published: January 2019

ABSTRACTSalmonella enterica serovar typhi is the causative agent of typhoid fever in human. The available vaccine lacks the effectiveness and further overuse of the antibiotics throughout the past decades lead to the emergence of antibiotic-resistant strains. To reduce the spread of antibiotic resistance, it is essential to develop new vaccines. In this study using an extensive bioinformatic analysis based on reverse vaccinology and subtractive genomics-based approach, we searched the genome of S typhi. We found that two outermost membrane proteins LptD and LptE, which are responsible for the final transport of the LPS across the membrane having most of the essential signature for being vaccine target. Both of these proteins are found highly conserved and possess shared surface epitopes among several species of Salmonella pathogens. This indicates that these two proteins could be the potential target for vaccine development, which could be effective for a broad range of Salmonella pathogens.
Computational deconvolution of gene expression in leukemic cell hierarchies
Authors: Jäarvstråt Linnea , Ajore Ram , Wihlborg Anna-Karin , Gullberg Urban , Nilsson Björn 
Published: January 2019

AbstractLeukemias and some solid tumors are organized as cell hierarchies, sustained by cancer stem cells. We developed a computational method to study gene expression cancer cell hierarchies. Unlike traditional approaches based on physical cell sorting, our method extracts cell type-specific gene expression signals from gene expression profiles of unsorted tumor cells by deconvolution. We apply our method in the context of acute myeloid leukemia, and recover markers for acute myeloid leukemia stem cells (AML-LSC).
Genome-wide CRISPR screening identifies new regulators of glycoprotein secretion
Authors: Popa Stephanie J. , Villeneuve Julien , Stewart Sarah , Garcia Esther Perez , Harrison Anna Petrunkina , Moreau Kevin 
Published: January 2019

ABSTRACTThe fundamental process of protein secretion from eukaryotic cells has been well described for many years, yet gaps in our understanding of how this process is regulated remain. With the aim of identifying novel genes involved in the secretion of glycoproteins, we used a screening pipeline consisting of a pooled genome-wide CRISPR screen followed by secondary siRNA screening of the hits to identify and validate several novel regulators of protein secretion. We present approximately 50 novel genes not previously associated with protein secretion, many of which also had an effect on the structure of the Golgi apparatus. We further studied a small selection of hits to investigate their subcellular localisation. One of these, GPR161, is a novel Golgi-resident protein that we propose maintains Golgi structure via an interaction with golgin A5.
Remarks about factors shaping the heliosphere
Authors: Ratkiewicz Romana , Konior Wojciech , Kotlarz Jan 
Published: January 2019

Purpose
The purpose of the paper is to give a brief description of the new topic introduced for the first time at the EASN Conferences.

Design/methodology/approach
The topic concerns the heliosphere, the nearest surrounding of the Sun and thus the nearest vicinity of the Earth. The heliosphere is created due to the interaction between the solar wind and the local interstellar medium.

Findings
This paper does not include any new information about the heliosphere and only introduces a new topic to this journal. It is briefly shown how heliospheric structures are formed, what factors affect a shape of the heliosphere, what measurements are made by Ulysses, Voyager and IBEX space missions (important for the heliosphere modeling) and how obtained data are used to validate theoretical results.

Practical implications
To categorize the paper under one of these classifications, research paper, viewpoint, technical paper, conceptual paper, case study, literature review or general review, the authors chose a paper type, general review, as the closest category to this paper. However, it is not a purpose of this paper to provide an extensive review of the community efforts to investigate the physical processes in the vicinity of the heliosphere interface. This is mostly a status report.

Originality/value
As the new topic in this journal, the article introduces in detail only a small number of aspects connected with heliosphere models. Interplanetary and interstellar magnetic field structures are primarily described. Other factors are only mentioned.
Achieving sustainable competitive advantage through green entrepreneurial orientation and market orientation
Authors: Pratono Aluisius Hery , Darmasetiawan Noviaty Kresna , Yudiarso Ananta , Jeong Bok Gyo 
Published: January 2019

Purpose
This paper aims to examine the role of the inter-organizational learning contributing in transforming the green entrepreneurial orientation and market orientation to the improvement of sustainable competitive advantages.

Design/methodology/approach
The structural equation model was established to explain the complex relationship between green entrepreneurial orientation, market orientation and sustainable competitive advantage. To test the hypothesis, this study used partial least square with data from a survey of 280 firms.

Findings
There is a strong tendency that the inter-organizational learning plays a pivotal role as an intervening variable that operates by receiving the input from green entrepreneurial orientation and market orientation, which plays as the exogenous construct. Hence, the greater inter-organizational learning leads the firms to achieve the greater sustainable competitive advantage.

Originality/value
This study extends the discussion on how organization should contribute to the well-being of the economic, social and environmental system by investigating the role of inter-organizational learning in achieving the sustainable competitive advantage.
The thinking process of the theory of constraints applied to public healthcare
Authors: Bauer Jéssica Mariela , Vargas Andrea , Sellitto Miguel Afonso , Souza Mariane Cásseres , Vaccaro Guilherme Luís 
Published: January 2019

PurposeThe purpose of this paper is to present an approach based on the thinking process of the theory of constraints (TP–TOC) to support decision-makers, managers and professionals of health to diagnose and improve healthcare systems focusing on the service quality deployed to patients.Design/methodology/approachA case study was developed in a SUS-affiliated philanthropic hospital in southern Brazil, through the analysis of its ED processes and application of the TP–TOC. The Current Reality Tree and the Evaporating Cloud tools of the TOC were used to identify the root causes (RC) and their connections with undesirable effects.FindingsThe analysis of this case helped to understand and identify the causes of the current problems in the analyzed processes related to internal management and external causes. The proposed approach allowed the hospital team to progress in the understanding of such causes in a sequential manner, giving conditions to apport different perceptions and to identify relevant facets and causes related to the problem. The research provided a systemic and an integrated vision of the losses in the organizational processes and indicated the steps to be prioritized in order to eliminate such losses.Originality/valueThe paper proposed an approach that allowed the systematic and systemic analysis of organizational processes through the application of the TP–TOC. The recognition of the existence of RC responsible for processes losses represents an excellent opportunity for improvement because it allows managers to focus their efforts on the more productive areas.
A paradoxical approach symbiotic to postmerger integration: a French longitudinal case study
Authors: Thelisson Anne-Sophie , Missonier Audrey , Guieu Gilles , Luscher Lotte S. 
Published: January 2019

PurposeThis paper aims to examine post-merger integration (PMI) through the lens of paradox to determine how paradoxes contribute to successful integration. Although PMI has been identified as crucial to understand merger success or failure, the literature on PMI drivers remains inconclusive.Design/methodology/approachDrawing on the theory of paradox and two key elements of PMI, strategic interdependency (SI) and organizational autonomy (OA), the authors describe the merger of two listed French companies using longitudinal data.FindingsThe authors identify how the paradox between OA and SI was triggered and fostered PMI success by leading to symbiotic integration. They also show that two capabilities were central in helping the paradox to evolve: preserving the specificities of the organizations and pooling their respective capabilities. These capabilities result from basic decisions and actions during the integration implementation, such as highlighting the expertise of the target firm, refocusing the core activity while valorizing each company’s expertise, clarifying the identity of the new organization on the market and enhancing joint piloting and transferring both general management capacity and functional abilities during the reorganization period.Practical implicationsThe authors offer several useful insights for managers trying to manage paradoxical tension throughout the merger process. This study encourages managers to embrace inconsistencies as they make decisions and to shift to dynamic decision-making as a way to adapt to complex contexts.Originality/valueThis study adopts a global and inclusive approach to focus on OA and SI and flesh out a picture of the integration process. It proposes a dynamic process model to conceptualize the stage-wise nature of the PMI process by highlighting the interrelations between OA and SI dynamics.
Waiting longer before claiming, and activating youth: no point?
Authors: Cockx Bart , Van Belle Eva 
Published: January 2019

PurposeThe purpose of this paper is to estimate the impact of two policies (an extension of the waiting period before entitlement to unemployment insurance (UI) and an intensification of counselling) targeted at unemployed school-leavers in Belgium on unemployment duration and on the quality of work.Design/methodology/approachThe length of both policies is sharply determined by two distinct age thresholds. These thresholds are exploited to estimate the impact within a regression discontinuity design using a large administrative data set of all recent labour market entrants.FindingsThe longer waiting period does not significantly impact job finding while the Youth Work Plan does increase the job-finding rate eight months after the onset of the programme. The accepted wage is unaffected, but both policies lower the number of working days resulting in lower earnings. This effect is especially prevalent for youth from low-income households.Research limitations/implicationsFor both policies, participation was delineated by an age cut-off which was only four months apart. This sizeably reduced the width of the age window to detect a corresponding discontinuity in behaviour and hereby also the statistical power of the estimator. Additionally, due to confounding policies the estimated effects are local treatment effects for highly educated youth around the age cut-offs.Social implicationsThe findings suggest that threatening with a sanction is not the right instrument to activate highly educated unemployed school-leavers. While supportive measures appear to be more effective, this may be partly a consequence of acceptance of lower quality jobs due to liquidity constraints and of caseworkers giving misleading advice that temporary jobs are stepping stones to long-term employment.Originality/valueTo the best of the authors’ knowledge, this is the first paper to estimate the impact of changing the waiting period in UI. The paper adds to the existing literature on the effects of counselling and UI design on employment and job quality.
Does welfare drive international migration? – a European experience
Authors: Jakubiak Igor Jerzy 
Published: January 2019

PurposeThe purpose of this paper is to provide a summary of empirical research on welfare magnetism and to assess the size and scope of the welfare magnet effect on the non-EU migrants in selected immigration countries of the European Union.Design/methodology/approachA conditional logistic regression model with interactions is used to estimate the strength of the welfare magnet effect, while controlling for demographic characteristics of the migrants and country-specific economic indicators. Data, used for estimation, comes from the Immigrant Citizen Survey, which provides a large, representative sample of first-generation (i.e. non-EU born) migrants. Various measures of welfare generosity are tested to assure the robustness of the results.FindingsThe coefficients suggest that the welfare magnet effect is present and significant in some immigrant groups, although it can have a negative impact on location decisions in other cases. Similar results are obtained for wage and unemployment indicators.Research limitations/implicationsResults corroborate the welfare magnet hypothesis, which states that more generous welfare states should expect greater clustering of negatively-selected (i.e. lower educated) migrants. One potential limitation comes from the sample size, which does not allow for more general conclusions.Practical implicationsHeterogeneous effects of basic economic indicators in different demographic groups show that aggregate immigrant flows, used widely in the literature, can provide biased estimates of welfare magnet effect.Originality/valueThis paper adds to the available literature by using representative, recently collected data and employing a more complete list of controls in a quantitative analysis of migration decisions.
Latecomers’ path-creating catch-up strategy in ICT industry
Authors: Kim Dae Bong , Park Min Jae 
Published: January 2019

Purpose
This study aims to empirically examine the conditions for latecomers to successfully pursue path-creating catch-up strategies. In particular, the company is divided into two conditions: the external environment, which refers to the gap in the market share between the leaders and latecomers, and the internal capacities of the company, such as the company’s absorptive capacity, re-combinative capabilities and technological innovation leadership.

Design/methodology/approach
Because firms supported by the government tend to be conservative in their decision-making and technology development strategies, governmental assistance is likely to negatively affect path-creating catch-up strategies. This study surveyed small to medium enterprises in the Korea IT industry and analyzed the latecomers’ catch-up strategies from internal and external environment perspectives.

Findings
After ensuring its innovation capacity by developing of internal capacity, it turned out to lead to path-creative catch-up strategy and market disparity and government dependence moderates this relation. While market disparity has a positive moderation effect, government dependence showed a negative moderation effect.

Originality/value
The authors proposed and tested hypotheses of how a firm’s path-creative catch-up strategy is adopted and succeeds. Regarding the internal conditions, the authors statistically proved that absorptive capabilities, re-combinative capabilities and technology innovation leadership are important factors for a firm’s technology innovation capacity.
Impact of information and communication technology in Nigerian small-to medium-sized enterprises
Authors: Okundaye Kessington , Fan Susan K. , Dwyer Rocky J. 
Published: January 2019

Purpose
The purpose of this (qualitative, multiple-case) study is to determine how small-to medium-sized enterprise (SME) leaders in Nigeria use information and communication technology (ICT) adoption as a business strategy to increase profitability and compete globally.

Design/methodology/approach
The participants for this study consisted of executive-level SME leaders who had the authority to approve ICT implementation within their respective organizations. Individual interviews were undertaken with participants to gain an understanding of their experience of determining the merits of and implementing ICT. The technology acceptance model, which specifies the relationship between perceived usefulness, perceived ease of use, attitude toward computer use and intention to use technology, was applied as a framework to explain the Nigerian SME’s ICT adoption strategies.

Findings
Four major themes emerged from the data analysis: ICT adoption factors, ICT roles and benefits, role of government and SME success factors. The findings of this study may help SME leaders and government leaders address many of the factors inhibiting the adoption of ICT in SMEs in Nigeria.

Practical implications
This study may ensure that SMEs are successful and able to create jobs, which in turn may help to promote socioeconomic development through adoption of ICT.

Originality/value
The findings from this study contribute to the knowledge base regarding factors that affect ICT adoption by SME leaders as a business strategy to increase profitability and compete globally, particularly within SMEs in Lagos, Nigeria. It further addressed the gap in existing literature regarding other factors such as the influence of culture on ICT adoption, cost of ICT implementation, available ICT skills, infrastructure and ICT knowledge gap as the primary impeding factors of ICT adoption in Nigerian SMEs.
Corruption and inflation: evidence from US states
Authors: Elkamel Hussein 
Published: January 2019

Purpose
The purpose of this paper is to show that states where corruption is greater also have higher levels of inflation.

Design/methodology/approach
Using a sample of all US states through the period 1992-2007 and various factors common across states that could impact the level of corruption or inflation, multiple regression techniques are used to determine corruption impact to inflation.

Findings
The study finds that corruption contributes, along with aid transfer, positively to inflation in the US states. The results are robust even after scaling the corruption variable to different determinants.

Originality/value
While there is some evidence on the relationship between corruption and inflation in cross-country dataset, there is no such evidence on it within country dataset. This paper, however, provides evidence on the relationship between corruption and inflation using state-level data of the US states.