bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of integrated heart failure care
Authors: MacInnes Julie , Williams Liz 
Published: June 2018

Abstract

Aim
The aim of this integrative review is to determine the effectiveness of integrated heart failure (HF) care in terms of patient-, service- and resource-related outcomes, and to determine what model or characteristics of integrated care work best, for whom and in what contexts.

Background
Integration of health and social care services is a significant driver in the development of better and more cost-effective health and social care systems in Europe and developed countries. As high users of health and social care services, considerable attention has been paid to the care of people with long-term conditions. HF is a progressive, prevalent and disabling condition, requiring complex management involving multiple health and social care agencies.

Methods
An integrative review was conducted according to a framework by Whittemore and Knafl (2005). A literature search was undertaken using the databases: Medline, CINAHL, Embase, PsychINFO and the Cochrane Library, using key words of ‘heart failure’ OR ‘cardiac failure’ AND ‘integrated’ OR ‘multidisciplinary’ OR ‘interdisciplinary’ OR ‘multiprofessional’ OR ‘interprofessional’ OR ‘collaborative care’. Application of the inclusion and exclusion criteria resulted in 17 articles being included in the review. Articles were screened and coded for methodological quality according to a two-point criteria. Data were extracted using a template and analysed thematically.

Findings
Integrated HF care results in enhanced quality of life (QoL), and improved symptom control and self-management. Reduced admission rates, reduced length of hospital stay, improved prescribing practices and better care co-ordination are also reported. There is more limited evidence for improved efficiency although overall costs may be reduced. Although findings are highly context dependent, key features of integrated HF models are: liaison between primary and secondary care services to facilitate planned discharge, early and medium term follow-up, multidisciplinary patient education and team working including shared professional education, and the development and implementation of comprehensive care pathways.
Long intergenic non-coding RNA 00324 promotes gastric cancer cell proliferation via binding with HuR and stabilizing FAM83B expression
Authors: Zou Zigui , Ma Tianshi , He Xuezhi , Zhou Jinxing , Ma Hongwei , Xie Min , Liu Yanhua , Lu Die , Di Shihao , Zhang Zhihong 
Published: June 2018

AbstractSubstantial evidence shows that long non-coding RNAs (lncRNAs) participate in many biological mechanisms, and their dysregulation are also involved in the development and progression of cancers, including gastric cancer (GC). Long intergenic non-coding RNA 00324 (LINC00324), a 2115 bp ncRNA, is located on chromosome 17p13.1. The biological function and molecular mechanisms of LINC00324 in GC remains undiscovered. In this paper, we found that the expression level of LINC00324 was significantly upregulated in GC tissues compared with the corresponding normal tissues. The overexpression of LINC00324 was correlated with advanced TNM stage, larger tumor size, and lymph node metastasis as well as poor prognosis. Further experiments revealed that knockdown of LINC00324 could suppress the proliferation of GC cells. RNA transcriptome sequencing technology revealed that FAM83B may be a significant downstream target gene of LINC00324. LINC00324 could combine with the RNA-binding protein (RBP) human antigen R (HuR) and thus stabilize the expression of FAM83B. Moreover, rescue assays showed that the reduced FAM83B expression partially reversed the promotion of cell growth in GC induced by the overexpression of LINC00324. In conclusion, our study revealed that LINC00324 acted as an oncogene in tumorigenesis and progression, suggesting that it could be a new biomarker in diagnosis and prognosis of GC.
TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
Authors: Maatouk Layal , Compagnion Anne-Claire , Sauvage Maria-Angeles Carrillo-de , Bemelmans Alexis-Pierre , Leclere-Turbant Sabrina , Cirotteau Vincent , Tohme Mira , Beke Allen , Trichet Michaël , Bazin Virginie , Trawick Bobby N. , Ransohoff Richard M. , Tronche François , Manoury Bénédicte , Vyas Sheela 
Published: June 2018

AbstractInflammation is a characteristic feature of Parkinson’s disease (PD). We examined the role of TLR9 and its regulation by glucocorticoid receptors (GRs) in degeneration of substantia nigra dopamine neurons (DNs). TLR9 agonist, CpG-ODN, induced DN degeneration in mice lacking GR in microglia but not in controls. TLR9 deletion reduced DN loss in neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. GR regulates TLR9 activation during MPTP neurotoxicity as TLR9 antagonist suppressed increased DN loss in microglia/macrophage GR mutant mice. GR absence in microglia enhanced TLR9 translocation to endolysosomes and facilitated its cleavage leading to pro-inflammatory gene expression. GR-dependent TLR9 activation also triggered DN loss following intranigral injection of mitochondrial DNA. Finally, microglial GR sensitivity to A53T-alpha-synuclein induced DN degeneration as well as decreased microglial GR expression observed in SN of PD brain samples, all suggest that reduced microglial GR activity in SN can stimulate TLR9 activation and DN loss in PD pathology.
Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
Authors: López-Camacho César , Abbink Peter , Larocca Rafael A. , Dejnirattisai Wanwisa , Boyd Michael , Badamchi-Zadeh Alex , Wallace Zoë R. , Doig Jennifer , Velazquez Ricardo Sanchez , Neto Roberto Dias Lins , Coelho Danilo F. , Kim Young Chan , Donald Claire L. , Owsianka Ania , De Lorenzo Giuditta , Kohl Alain , Gilbert Sarah C. , Dorrell Lucy , Mongkolsapaya Juthathip , Patel Arvind H. , Screaton Gavin R. , Barouch Dan H. , Hill Adrian V. S. , Reyes-Sandoval Arturo 
Published: June 2018

AbstractZika virus (ZIKV) emerged on a global scale and no licensed vaccine ensures long-lasting anti-ZIKV immunity. Here we report the design and comparative evaluation of four replication-deficient chimpanzee adenoviral (ChAdOx1) ZIKV vaccine candidates comprising the addition or deletion of precursor membrane (prM) and envelope, with or without its transmembrane domain (TM). A single, non-adjuvanted vaccination of ChAdOx1 ZIKV vaccines elicits suitable levels of protective responses in mice challenged with ZIKV. ChAdOx1 prME ∆TM encoding prM and envelope without TM provides 100% protection, as well as long-lasting anti-envelope immune responses and no evidence of in vitro antibody-dependent enhancement to dengue virus. Deletion of prM and addition of TM reduces protective efficacy and yields lower anti-envelope responses. Our finding that immunity against ZIKV can be enhanced by modulating antigen membrane anchoring highlights important parameters in the design of viral vectored ZIKV vaccines to support further clinical assessments.
Exploring the resilience of wheat crops grown in short rotations through minimising the build-up of an important soil-borne fungal pathogen
Authors: McMillan V. E. , Canning G. , Moughan J. , White R. P. , Gutteridge R. J. , Hammond-Kosack K. E. 
Published: June 2018

AbstractGiven the increasing demand for wheat which is forecast, cropping of wheat in short rotations will likely remain a common practice. However, in temperate wheat growing regions the soil-borne fungal pathogen Gaeumannomyces tritici becomes a major constraint on productivity. In cultivar rotation field experiments on the Rothamsted Farm (Hertfordshire, UK) we demonstrated a substantial reduction in take-all disease and grain yield increases of up to 2.4 tonnes/ha when a low take-all inoculum building wheat cultivar was grown in the first year of wheat cropping. Phenotyping of 71 modern elite wheat cultivars for the take-all inoculum build-up trait across six diverse trial sites identified a few cultivars which exhibited a consistent lowering of take-all inoculum build-up. However, there was also evidence of a significant interaction effect between trial site and cultivar when a pooled Residual Maximum Likelihood (REML) procedure was conducted. There was no evidence of an unusual rooting phenotype associated with take-all inoculum build-up in two independent field experiments and a sand column experiment. Together our results highlight the complex interactions between wheat genotype, environmental conditions and take-all inoculum build-up. Further work is required to determine the underlying genetic and mechanistic basis of this important phenomenon.
Lattice Boltzmann modeling to explain volcano acoustic source
Authors: Brogi Federico , Ripepe Maurizio , Bonadonna Costanza 
Published: June 2018

AbstractAcoustic pressure is largely used to monitor explosive activity at volcanoes and has become one of the most promising technique to monitor volcanoes also at large scale. However, no clear relation between the fluid dynamics of explosive eruptions and the associated acoustic signals has yet been defined. Linear acoustic has been applied to derive source parameters in the case of strong explosive eruptions which are well-known to be driven by large overpressure of the magmatic fluids. Asymmetric acoustic waveforms are generally considered as the evidence for supersonic explosive dynamics also for small explosive regimes. We have used Lattice-Boltzmann modeling of the eruptive fluid dynamics to analyse the acoustic wavefield produced by different flow regimes. We demonstrate that acoustic waveform well reproduces the flow dynamics of a subsonic fluid injection related to discrete explosive events. Different volumetric flow rate, at low-Mach regimes, can explain both the observed symmetric and asymmetric waveform. Hence, asymmetric waveforms are not necessarily related to the shock/supersonic fluid dynamics of the source. As a result, we highlight an ambiguity in the general interpretation of volcano acoustic signals for the retrieval of key eruption source parameters, necessary for a reliable volcanic hazard assessment.
Effect of Biomolecules on the Nanostructure and Nanomechanical Property of Calcium-Silicate-Hydrate
Authors: Kamali Mahsa , Ghahremaninezhad Ali 
Published: June 2018

AbstractInspired by nature, this paper investigates the effect of biomolecules, such as amino acids and proteins, on the nanostructure and mechanical stiffness of calcium-silicate-hydrate (C-S-H). Amino acids with distinct functional groups, and proteins with different structures and compositions were used in the synthesis of the C-S-H nanocomposite. The atomic structure was examined using X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The morphology was investigated using scanning electron microscopy (SEM) and atomic force microscopy (AFM). AFM nanoindentation was used to evaluate the Young’s modulus of the modified C-S-H. Positively charged, H-bond forming and hydrophobic amino acids were shown to influence the atomic structure of C-S-H. The effect of negatively charged amino acid on atomic structure was more pronounced at higher C/S ratio. A noticeable increase in silicate polymerization of C-S-H modified with proteins at high C/S ratio was observed. The microscopic examination demonstrated a globular morphology for all samples except for C-S-H modified with hemoglobin, which showed a platelet morphology. The Young’s modulus of C-S-H with amino acids and proteins showed a general reduction compared to that of the control C-S-H.
Communicative mind-reading in preverbal infants
Authors: Tauzin Tibor , Gergely György 
Published: June 2018

AbstractPragmatic theories of communication assume that humans evolved a species-unique inferential capacity to express and recognize intentions via communicative actions. We show that 13-month-old non-verbal infants can interpret the turn-taking exchange of variable tone sequences between unfamiliar agents as indicative of communicative transfer of goal-relevant information from a knowledgeable to a naïve agent pursuing the goal. No such inference of information transfer was drawn by the infants, however, when a) the agents exchanged fully predictable identical signal sequences, which does not enable transmission of new information, or b) when no goal-relevant contextual change was observed that would motivate its communicative transmission. These results demonstrate that young infants can recognize communicative interactions between third-party agents and possess an evolved capacity for communicative mind-reading that enables them to infer what contextually relevant information has been transmitted between the agents even without language.
Defibrinogen Therapy for Acute Ischemic Stroke: 1332 Consecutive Cases
Authors: Chen Jing , Sun Dalong , Liu Mingli , Zhang Shufan , Ren Chuancheng 
Published: June 2018

AbstractThis study aimed to examine the effectiveness of defibrinogen therapy on functional recovery and safety among 1332 consecutive ischemic stroke patients who had not received intravenous thrombolysis with recombinant tissue plasminogen activator. Stroke patients undergoing conservative and relatively individualized multiple-day dosing regimens of defibrinogen therapy between January 1, 2008 and May 30, 2016 were enrolled. Data were analyzed according to functional success (Barthel Index of 95 or 100, mRS of 0 or 1) and safety variables (intracranial hemorrhage, mortality and stroke recurrence). At 12 months, 18.62% (203/1087) of patients were lost to follow-up. The functional success rates were 39.84% (526/1320) and 42.23% (459/1087) as assessed by BI at 3 months and 12 months, respectively. Fifteen patients had asymptomatic intracranial hemorrhage within 24 hours after the initial defibrase administration. During the 14 days after hospitalization, 12 patients were diagnosed with symptomatic intracranial hemorrhage (sICH) and a total of 12 patients died from all causes. At 3 months, 56 patients were dead and 21 patients had recurrent stroke. The percentage of death and recurrence of stroke at 12 months were 6.81% and 3.22%, respectively. Results from the historical control showed no significant differences of functional success were detected between the patients treated with rt-PA within 6 hours of stroke onset in NINDS II and the patients treated with defibrase within 6 hours after stroke in the present study. The multiple-day dosing regimen of defibrinogen therapy using defibrase applied in the present study could achieve functional improvement among acute ischemic stroke patients, with low risks of mortality when compared with other similar studies. However, the efficacy and safety of such a defibrinogenating therapy is needed to be verified by RCTs with large sample size.
Amygdala enlargement and emotional responses in (autoimmune) temporal lobe epilepsy
Authors: Holtmann Olga , Schlossmacher Insa , Moenig Constanze , Johnen Andreas , Rutter Lisa-Marie , Tenberge Jan-Gerd , Schiffler Patrick , Everding Judith , Golombeck Kristin S. , Strippel Christine , Dik Andre , Schwindt Wolfram , Wiendl Heinz , Meuth Sven G. , Bruchmann Maximilian , Melzer Nico , Straube Thomas 
Published: June 2018

AbstractTemporal lobe epilepsy with amygdala enlargement (TLE-AE) is increasingly recognized as a distinct adult electroclinical syndrome. However, functional consequences of morphological alterations of the amygdala in TLE-AE are poorly understood. Here, two emotional stimulation designs were employed to investigate subjective emotional rating and skin conductance responses in a sample of treatment-naïve patients with suspected or confirmed autoimmune TLE-AE (n = 12) in comparison to a healthy control group (n = 16). A subgroup of patients completed follow-up measurements after treatment. As compared to healthy controls, patients with suspected or confirmed autoimmune TLE-AE showed markedly attenuated skin conductance responses and arousal ratings, especially pronounced for anxiety-inducing stimuli. The degree of right amygdala enlargement was significantly correlated with the degree of autonomic arousal attenuation. Furthermore, a decline of amygdala enlargement following prompt aggressive immunotherapy in one patient suffering from severe confirmed autoimmune TLE-AE with a very recent clinical onset was accompanied by a significant improvement of autonomic responses. Findings suggest dual impairments of autonomic and cognitive discrimination of stimulus arousal as hallmarks of emotional processing in TLE-AE. Emotional responses might, at least partially, recover after successful treatment, as implied by first single case data.
Light extraction from fundamental modes in modulated waveguides for homogeneous side-emission
Authors: Pan Zhiwen , Wondraczek Lothar 
Published: June 2018

AbstractDedicated control of axial light emission from light-guides enables a new generation of functional light sources for volumetric illumination. A primary challenge is to ensure homogeneous emission intensity across the full length of the device. Here, we introduce an approach towards homogeneously side-emitting waveguides which do not rely on imposing local scattering centers such as bubbles, micro-/nanoparticles, and rough or abrupt interfaces, but on modulated core radius. Previous quantitative studies of the relationship between structural parameters and radiation losses provide initial conditions for tailoring side-emission through core-diameter modulations, however, with strongly limited amplitude of modulation. We now employ and verify numerical simulation to overcome this limitation towards meter-long homogeneously side-emitting waveguides in which the amplitude of core-diameter modulation is of the same order of magnitude as the core diameter itself. Similar emission properties can be obtained through modulation of the core refractive index instead of the core diameter, or through a combination of both approaches. Using the present model, we deduce exemplary conditions for homogeneous side-emission in which the power flow within the waveguides decays linearly, what may present another interesting feature for applications beyond illumination.
Atlantic Niño modulation of the Indian summer monsoon through Asian jet
Authors: Yadav Ramesh Kumar , Srinivas G. , Chowdary Jasti S. 
Published: June 2018

AbstractThe Indian rainfall and the Atlantic Niño peaks during summer month and have inverse relationship. This relationship has been revisited in the current study and it is found that the Atlantic Niño significantly influences a dipole pattern of rainfall in the north–east and the north-western parts of India. The positive phase of the Atlantic Niño intensifies the inter-tropical convergence zone, as a result of this local tropospheric warming, over the equatorial east Atlantic and west Africa, owing to the enlargement of the upper-troposphere divergence. This provokes meridional stationary wave owing to the stronger meridional transfer of energy, as the influences of background jet-streams are minimal over North Africa and Europe. This results in the consecutive anomalous negative, positive, and negative geopotential heights (GPHs) over the tropical east Atlantic, Mediterranean, and north–west Europe, respectively. The north–west Europe acts as the center of action for the propagation of a Rossby wave train zonally oriented toward central Asia reinforcing positive GPH anomaly over there. The positive GPH anomaly reduces the Asian subtropical westerly jet-stream east of the Caspian Sea, owing to the reduction in the upper-troposphere divergence toward the Indian subcontinent and caused for above (below) normal north–east (north–west) Indian summer monsoon rainfall. The atmospheric general circulation model captures general characteristics of wave pattern and changes in the Asian jet when correlated with Atlantic Niño with considerable skill.
Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways
Authors: Young M. , Dahoun T. , Sokrat B. , Arber C. , Chen K. M. , Bouvier M. , Barth P. 
Published: June 2018

Significance
Membrane receptors sense and translate extracellular signals into specific intracellular functions and represent powerful molecules for biomedicine and synthetic biology. However, the computational design of receptors with novel signaling functions remains challenging because receptors often couple to multiple intracellular proteins with poorly characterized interactions. We developed a computational approach to model and rationally engineer orthogonal receptor-intracellular protein pairs that bind and signal with high selectivity. The orthogonal receptor-effector systems coupled with high efficiency and triggered the intended cellular functions without interfering with natural systems. The designed proteins displayed key, distinct sequence motifs when compared with native proteins, which expanded the alphabet of receptor-effector recognition. This design approach can be used to reprogram cellular functions in cell-engineering applications.
Error-prone protein synthesis in parasites with the smallest eukaryotic genome
Authors: Melnikov Sergey V. , Rivera Keith D. , Ostapenko Denis , Makarenko Arthur , Sanscrainte Neil D. , Becnel James J. , Solomon Mark J. , Texier Catherine , Pappin Darryl J. , Söll Dieter 
Published: June 2018

Significance
Microsporidia are poorly treatable eukaryotic pathogens that threaten human health and industrially valuable insects and fish, yet we are only beginning to understand the complex biology of these emerging pathogens. Here we combine bioinformatics, biochemistry, and mass spectrometry analyses to show that Microsporidia carry an error-prone machinery of protein synthesis, and that their protein synthesis is accompanied by a remarkable number of translation errors. This finding reveals a previously unknown aspect of protein synthesis in these emerging parasites and creates a potential opportunity to use the defective protein synthesis machinery as a therapeutic target to treat microsporidia infections.
Hyperstimulation of CaSR in human MSCs by biomimetic apatite inhibits endochondral ossification via temporal down-regulation of PTH1R
Authors: Sarem Melika , Heizmann Miriam , Barbero Andrea , Martin Ivan , Shastri V. Prasad 
Published: June 2018

Significance
Bone formation occurs through two distinct pathways, namely, endochondral ossification (EO) and intramembranous ossification (IMO). While significant effort has gone into understanding the role of various soluble signals in EO and IMO, the impact of the bone inorganic interface in triggering these ossification pathways has remained unexplored. Herein, we report the discovery that the bone-like mineral phase promotes formation of bone by mesenchymal stem/stromal cells (MSCs) exclusively via IMO even in the presence of soluble signals that promote the EO paradigm. Furthermore, we provide mechanistic insights into our observations and illustrate a previously unidentified role for extracellular calcium-sensing receptor (CaSR) in dictating the choice of ossification pathway in MSCs. These findings have significant implications for developing new strategies for bone repair and understanding bone homeostasis.
Written languages, East-Asian scripts, and cross-linguistic influences
Authors: Pae Hye K. 
Published: June 2018

Abstract
This chapter describes the realm of writing systems, scripts, and orthographies focusing on three East-Asian languages – Chinese, Japanese, and Korean. With the operational definitions of basic terms, it identifies the visual resemblances in square blocks as the essential feature underlying commonalities among the three scripts as well as the internal structures of words and linguistic units as the crucial features behind dissimilarities. Next, it describes the scope and breadth of cross-linguistic influences and how models and theories of word processing can be established through cross-linguistic research. The chapter closes with the book’s objectives, intended audiences, and organization.