bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of infliximab in very early onset inflammatory bowel disease: a national comparative retrospective study
Authors: Bramuzzo Matteo , Arrigo Serena , Romano Claudio , Filardi Maria Chiara , Lionetti Paolo , Agrusti Anna , Dipasquale Valeria , Paci Monica , Zuin Giovanna , Aloi Marina , Strisciuglio Caterina , Miele Erasmo , Pastore Maria , Martelossi Stefano , Alvisi Patrizia ,   SIGENP IBD Working Group
Published: April 2019

BackgroundVery few data regarding the use of infliximab in children with very early‐onset inflammatory bowel disease (VEO‐IBD) have been reported.ObjectiveWe aimed to assess the efficacy and the safety of infliximab in children with VEO‐IBD compared with older children.MethodsChildren treated with infliximab were identified within the Italian IBD registry. The primary outcome was the rate of clinical remission at weeks 14 and 54. Secondary outcomes included the proportion of partial clinical response, treatment duration, and incidence of adverse events.ResultsForty‐two children with VEO‐IBD were compared with 130 children with IBD. Despite significantly higher infliximab withdrawals in VEO‐IBD patients during induction (42.9% vs 7.7% p < 0.01), remission rates at week 14 were similar (28.6% vs 43.8%, p = 0.10). At week 54 fewer VEO‐IBD children were in remission (15.8% vs 54.3%, p < 0.01). The treatment duration was shorter in VEO‐IBD (median 12.0 vs 18.4 months, p < 0.01). During the induction phase, adverse events were more common in the VEO‐IBD group (p < 0.01).ConclusionCompared with older children, VEO‐IBD patients have higher rates of infliximab failures, lower remission rates at one year, and more often experience adverse events during induction.
Oral Health Status and Treatment Needs of Soft Drink Factory Workers of Madurai City: A Cross-sectional Study
Authors: Vidhya G.  , Muthu Karuppaiah R.  , Garla Bharath Kumar , Umesh K.  , Taranath M. , Pandian Palanivel 
Published: April 2019

Background:Oral health is an integral part of general health. Good oral health helps people to communicate and enhances their dignity and personality. Oral health of soft drink factory workers depended on their working environment.Aims and objectives:To assess the oral health status and treatment needs of soft drink factory workers in Madurai city, Tamil Nadu, India.Materials and methods:A cross-sectional survey was conducted on 175 soft drink factory workers. Informed consent from the participants and ethical clearance were obtained. Data were collected by using WHO Oral Health Assessment Form for Adults, 2013.Results:The result shows higher prevalence of oral problems with 80% dental caries, 82.9% gingival bleeding, 13.7% periodontal pockets, 15.4% loss of attachment, 54.9% fluorosis, and 50.9% dental erosion in soft drink factory workers.Conclusion:The study suggests that the oral health status of these soft drink factory workers is poor and there is an increased need for their dental treatment.
Clinical Utility of an MRI-Based Classification System for Operative Versus Nonoperative Management of Ulnar Collateral Ligament Tears: A 2-Year Follow-up Study
Authors: Ramkumar Prem N. , Haeberle Heather S. , Navarro Sergio M. , Frangiamore Salvatore J. , Farrow Lutul D. , Schickendantz Mark S. 
Published: April 2019

Background: A recently introduced classification system of medial ulnar collateral ligament (UCL) tears accounting for location and severity has demonstrated high interobserver and intraobserver reliability, but little is known about its clinical utility. Purpose: The primary purpose of this study was to assess the relationship of the magnetic resonance imaging (MRI)–based classification system in predicting which athletes had success with nonoperative versus operative treatment after completing a standardized rehabilitation program. A secondary objective included return to play (RTP) and return to prior performance (RPP) analyses of baseball players. Study Design: Cohort study; Level of evidence, 3. Methods: After an a priori power analysis, 58 consecutive patients with UCL tears and a minimum of 2-year follow-up were retrospectively divided into 2 groups: those who successfully completed operative treatment and those who completed nonoperative treatment. The MRI-based classification stages accounting for UCL tear location and severity were compared between the nonoperative and operative groups. A subanalysis for baseball players, including RTP and RPP, was performed. Results: A total of 58 patients (40 baseball players [34 pitchers]) met inclusion criteria. Of these patients 35 (32 baseball players [27 pitchers]) underwent surgery, and 23 (8 baseball players [7 pitchers]) underwent nonoperative management. No patients in the nonoperative arm crossed over to surgery after completing the rehabilitation program. Patients with distal tears (odds ratio, 48.0; P = .0004) and complete tears (odds ratio, 5.4; P = .004) were more likely to undergo surgery. Baseball players, regardless of position, were confounding determinants of operative management, although there was no difference in RTP and RPP between treatment arms. Conclusion: A 6-stage MRI-based classification system addressing UCL tear location and severity may help early decision making, as patients likely to fail nonoperative treatment have complete, distal tears, whereas those with proximal, partial tears may be more amenable to nonoperative management.
Reduced Time to Positive Cutibacterium acnes Culture Utilizing a Novel Incubation Technique: A Retrospective Cohort Study
Authors: Bokshan Steven L , Ramirez Gomez Jose , Chapin Kimberle C , Green Andrew , Paxton E Scott 
Published: April 2019

Introduction Cutibacterium acnes ( C. acnes) is a common pathogen in postoperative shoulder infections. The purpose of this study was to evaluate the time to positive cultures for C. acnes and compare our experience before and after implementation of a regulated anaerobic chamber system. We hypothesized that this would reduce the time to identify positive cultures. Methods This was a retrospective review of 34 patients with cultures obtained from the shoulder that were positive for C. acnes. The time until positive result was evaluated before and after implementation of a regulated anaerobic incubation chamber. Results Following implementation of the regulated anaerobic incubation chamber, the time until C. acnes culture growth significantly decreased from 6.5 days (range 3–10 days) to 4.9 days (range 2.75–10 days) (mean difference: 1.6 days, 95% confidence interval: 1.06–2.66 days; P = .002). True infections had a significantly shorter time to positive culture compared to contaminants (5.5 vs 6.8 days, respectively, P = .003). Increased number of positive culture specimens correlated with a shorter time to positivity (Spearman rank = −0.58, P = .007). Conclusion Improved anaerobic culture protocols and techniques may lead to greater accuracy and earlier diagnosis and initiation of treatment of postoperative shoulder infections.
A niche-dependent myeloid transcriptome signature defines dormant myeloma cells
Authors: Khoo Weng Hua , Ledergor Guy , Weiner Assaf , Roden Daniel L. , Terry Rachael L. , McDonald Michelle M. , Chai Ryan C. , De Veirman Kim , Owen Katie L. , Opperman Khatora S. , Vandyke Kate , Clark Justine R. , Seckinger Anja , Kovacic Natasa , Nguyen Akira , Mohanty Sindhu T. , Pettitt Jessica A. , Xiao Ya , Corr Alexander P. , Seeliger Christine , Novotny Mark , Lasken Roger S. , Nguyen Tuan V. , Oyajobi Babatunde O. , Aftab Dana , Swarbrick Alexander , Parker Belinda , Hewett Duncan R. , Hose Dirk , Vanderkerken Karin , Zannettino Andrew C. W. , Amit Ido , Phan Tri Giang , Croucher Peter I. 
Published: April 2019

AbstractThe era of targeted therapies has seen significant improvements in depth of response, progression-free survival, and overall survival for patients with multiple myeloma. Despite these improvements in clinical outcome, patients inevitably relapse and require further treatment. Drug-resistant dormant myeloma cells that reside in specific niches within the skeleton are considered a basis of disease relapse but remain elusive and difficult to study. Here, we developed a method to sequence the transcriptome of individual dormant myeloma cells from the bones of tumor-bearing mice. Our analyses show that dormant myeloma cells express a distinct transcriptome signature enriched for immune genes and, unexpectedly, genes associated with myeloid cell differentiation. These genes were switched on by coculture with osteoblastic cells. Targeting AXL, a gene highly expressed by dormant cells, using small-molecule inhibitors released cells from dormancy and promoted their proliferation. Analysis of the expression of AXL and coregulated genes in human cohorts showed that healthy human controls and patients with monoclonal gammopathy of uncertain significance expressed higher levels of the dormancy signature genes than patients with multiple myeloma. Furthermore, in patients with multiple myeloma, the expression of this myeloid transcriptome signature translated into a twofold increase in overall survival, indicating that this dormancy signature may be a marker of disease progression. Thus, engagement of myeloma cells with the osteoblastic niche induces expression of a suite of myeloid genes that predicts disease progression and that comprises potential drug targets to eradicate dormant myeloma cells.
Prescribing Response Strategies to Manage Customer Opinions: A Stochastic Differential Equation Approach
Authors: Yang Mingwen , Zheng Zhiqiang (Eric) , Mookerjee Vijay 
Published: April 2019

Today, the reputation of a firm is profoundly influenced by user opinions expressed in online consumer reviews. Managing these opinions is, therefore, critical for the success of firms. We study the problem of devising an appropriate opinion management strategy (or response strategy) for a firm to respond to online customer reviews. To unravel the underlying mechanics of the problem, we develop a stochastic differential equation model that describes the evolution of review ratings over time for a given response strategy employed by the firm. This model is validated using data on online customer reviews and firm responses from two of the world’s largest online travel agents. When pitted against popular benchmark models, such as autoregressive moving average, generalized autoregressive conditional heteroscedasticity, moving average, exponential smoothing, and naive method, our approach not only achieves comparable (often better) predictive performance, it is also able to incorporate the response strategy into the data-generation process underlying the review ratings. Our approach, therefore, is not just predictive, but, more importantly, one that can be used in a prescriptive sense, namely to prescribe a response strategy that controls review ratings in a desired manner. We operationalize the theoretical response strategy in our stochastic model to an operational prescription that a firm can implement and show the applicability of our approach for different business objectives, such as mean control, mean-variance control, and service-level control. Finally, we demonstrate the flexibility of the stochastic differential equation model by extending it to encompass multiple state variables. The online appendices are available at https://doi.org/10.1287/isre.2018.0805 .
Getting the Rich and Powerful to Give
Authors: Kessler Judd B. , Milkman Katherine L. , Zhang C. Yiwei 
Published: April 2019

What motivates the rich and powerful to exhibit generosity? We explore this important question in a large field experiment. We solicit donations from 32,174 alumni of an Ivy League university, including thousands of rich and powerful alumni. Consistent with past psychology research, we find that the rich and powerful respond dramatically, and differently than others, to being given a sense of agency over the use of donated funds. Gifts from rich and powerful alumni increase by 100%–350% when they are given a sense of agency. This response arises primarily on the intensive margin with no effect on the likelihood of donating. Results suggest that motivating the rich and powerful to act may require tailored interventions. This paper was accepted by Uri Gneezy, behavioral economics.
Evaluation of Dominant Parameters in Lipase Transesterification of Cottonseed Oil
Authors: Anderson Stanley , Walker Terry , Moser Bryan , Drapcho Caye , Zheng Yi , Bridges William 
Published: April 2019

Abstract. Eversa Transform was used as an enzymatic catalyst to transform glandless and crude (heavy pigment) cottonseed oils into biodiesel. The oils were reacted with methanol at a 6:1 molar ratio with modified amounts of water, lipase, and temperature. Reactions were conducted in the presence of lipase and water at doses of 2, 5, and 8 wt% and 1, 3, and 6 wt%, respectively. Product composition and conversion were determined using the gas chromatography method of ASTM D6584. Oxidative stability was determined following EN 15751. The conversion to fatty acid methyl esters averaged 98.5% across all samples. Temperature had the most significant effect on conversion (p &lt; 0.0035). Lipase and water dosages did not affect conversion, while each had an effect with temperature that was significant across the difference between 3 and 1 wt% water content and between 8 and 5 wt% enzyme content between the two temperatures (p = 0.0018 and 0.0153), respectively. Induction periods (oxidative stability) of the glandless and crude cottonseed oils were significantly different, but there was no difference between the two oil conversions based on oil type. Keywords: Biodiesel, Cottonseed oil, Fatty acid methyl esters, Lipase, Oxidative stability, Transesterification.
Development and Preliminary Evaluation of an Integrated Individual Nozzle Direct Injection and Carrier Flow Rate Control System for Pesticide Applications
Authors: Luck Joe D. , Shearer Scott A. , Sama Michael P. 
Published: April 2019

Abstract. Direct injection systems for agricultural spray applications continue to present challenges in terms of commercialization and adoption by end users. Such systems have typically suffered from lag time and mixing uniformity issues, which have outweighed the potential benefits of keeping chemical and carrier separate or reducing improper tank-mixed concentration by eliminating operator measurements. The proposed system sought to combine high-pressure direct nozzle injection with an automated variable-flow nozzle to improve chemical mixing and response times. The specific objectives were to: (1) integrate a high-pressure direct nozzle injection system with variable-flow carrier control into a prototype for testing, (2) assess the chemical metering accuracy and proper mixing at different combinations of injection valve frequency and duty cycle along with chemical pressure, and (3) assess the ability of the control system to ensure proper chemical dilutions and concentrations in the nozzle effluent resulting from step changes in target application rates. Laboratory experiments were conducted using the combined system. Results of these experiments showed that the open-loop control of the injectors could provide a means of accurately metering the chemical concentrate into the carrier stream. Chemical injection rates could be achieved with an average error of 5.4% compared to the target rates. Injection at higher duty cycles resulted in less error in the chemical concentration predictions. Discrete Fourier transform analysis showed that the injection frequency was noticeable in the nozzle effluent when the injector was operated at 3.04 MPa and 5 Hz (particularly at lower duty cycles). Increasing the injection pressure and operating frequency to 5.87 MPa and 7 Hz, respectively, improved mixing, as the injection frequency component was no longer noticed in the effluent samples. The variable-flow nozzle was able to maintain appropriate carrier flow rates to achieve product label chemical concentrations. In one case, the maximum allowable concentrate was exceeded, although the nozzle was able to recover in 0.5 s. Steady-state errors ranged from 2.5% to 7.5% for chemical concentrations compared to the selected chemical to carrier ratio (0.03614). This test scenario represented an application rate of 4.68 L ha-1 with velocity increases from 4.0 to 7.1 m s-1 and decreases from 7.1 to 4.0 m s-1, which were typical of the example field application data. Keywords: Pesticides, Precision agriculture, Spraying equipment, Variable-rate application.
Prevalence, Health and Resource Utilization, and Unmet Healthcare Needs of Native Hawaiian and Pacific Islander Children With Developmental Disabilities
Authors: Payakachat Nalin , Long Christopher R. , McElfish Pearl A. , Narcisse Marie-Rachelle , Felix Holly C. , Bursac Zoran , Hudson Teresa J. 
Published: April 2019

Abstract
Little is known about health limitations and service utilization among the Native Hawaiian and Pacific Islander (NHPI) children with developmental disabilities (DDs) due to limited data. Our study examined the prevalence of DDs, health limitations, services used, and the unmet needs of NHPI children aged 3 to 17 years using cross-sectional data from the 2014 NHPI National Health Interview Survey. Results showed that prevalence of DDs among NHPI children was lower than American children of other races. DDs were negatively associated with health and functioning of NHPI children. There is a need to promote understanding of DDs among NHPI families and to inform public policy makers to identify appropriate intervention services for NHPI children.
Diferentes perspectivas de alfabetização a partir da Base Nacional Comum Curricular: concepções e desafios /Different perspectives of literacy from the National Common Curriculum Base: concepts and challenges
Authors: Bortolanza Ana Maria Esteves , Goulart Ilsa do Carmo Vieira , Cabral Giovanna Rodrigues 
Published: April 2019

A Base Nacional Comum Curricular (BNCC) se constitui como um documento de caráter normativo norteador dos currículos dos sistemas e redes de ensino, bem como das propostas pedagógicas de todas as escolas públicas e privadas de Educação Básica de todo o Brasil. Neste artigo, nossa proposta é a de refletir sobre o sentido atribuído Ã alfabetização na versão final aprovada da BNCC, com intuito de problematizar as descrições de aspectos legais instituídos pelo documento, com destaque aos elementos que permanecem ou diferem-se em relação aos demais documentos oficiais sobre o tema. Para tanto, desenvolve-se uma pesquisa descritiva, de cunho qualitativo, apoiada na análise do documento oficial da BNCC e nas orientações a respeito da alfabetização, com base nos estudos do processo de compreensão da leitura e escrita de Bajard (2006) e Vygotsky (2000), da concepção de leitura como prática social de produção de sentidos de Chartier (1990; 1996) e Goulemot (1996).PALAVRAS-CHAVE: Base Nacional Comum Curricular. Alfabetização. Leitura. Escrita. Políticas de alfabetização.
Analysis of Component based Computing
Authors: V. Kumaraguru P. , J. Chakravarthy V. , Seenivasan M. 
Published: April 2019

To achieve a precise goal of components on different platforms that are presented the some components in order to co-operate with one another over a communication network. The component should be able to access services provided through remote, location transparent service in vocations.The major role of component-based method is represent an ideal framework for component-driven in client/server computing. One of the good implementation examples of broker architecture is Common Object Request Broker Architecture (CORBA). The component based technologies discuss the proposal of distributed object of CORBA which is the Object Management Groupâ€™s (OMG).This paper proposes the broker architecture as CORBA has distributed system that can be demonstrated by client-server architecture which practices the base for multi-tier architecture.Â Â
A Study on Employer Branding Dimensions in Selected IT Firms
Authors: Bharath S. , Nagesh P. , . . 
Published: April 2019

The factors associated with branding were identified beneath communication/marketing remit.Â There existed no difference between the employer brand and consumer brand.Â Companies who had strong product/ service brand would de facto be attractive to potential employees. Today, companies require blended capabilities. Ultimately, it is the personal experience of the relationship that a person develops within an organization that determines the longevity and win-win consummation of association. An extended concept of relationship marketing principle is Employer branding. An endeavor has been made through this research with an objective to identify the Employer Branding Dimensions (EBD) in selected Information technology firms located in Bangalore from existing employee perspective. Study has been executed using structured questionnaire with Information Technology (IT) employees as respondents from various companies like, Infosys, IBM, NTT DATA, Marvell technologies, JDA software solutions. Data thus collected is analysed using software package and considering the factor loadings, key dimensions (factors) that constituted the Employer branding. The findings of the study emphasize that relationship among dimensions constituting individual employer branding highlights the complexity in its significance as no individual factor has dominant influence on Employer Branding. But many factors in combination acts on branding.Â Â Â
An Empirical Analysis of Significant Factors influencing Entrepreneurial Behavior in the Information Technology Industry
Authors: Kasanagottu Suresh , Bhattachar Sudipto , . . 
Published: April 2019

The purpose of the current empirical research paper is to study and comprehend the significant factors that influence the entrepreneurial behavior through a detailed survey among the key employees of the information technology (IT) industry. The data thus collected from the survey was examined through the method of Partial Least Squares (PLS) for evaluating the relationship among the constructs of the conceptual research model. The results of the current empirical research study reveal that entrepreneurship-institutional linkage has the strongest effect on entrepreneurial behavior, followed by role of outsourcing and nature of the industry. The hypothesized path relationships between significant factors and entrepreneurial behavior have been found to be statistically significant. The top management of the companies in the IT industry have to focus and provide more importance to the entrepreneurship-institutional linkages which plays a key role in developing entrepreneurial behavior among the employees and in due course lead to innovative products and services and the over-all development of the organization.Â Â Â Â Â Â
A Comparative Study of Factors Influencing Purchasing Decisions at D-Mart and Metro in Vijayawada City.
Authors: Satish Kumar D. , Bindu P. , S. Rao D. , Anusha S. , Srinivas J. 
Published: April 2019

Corporate retail stores are today the focal points for purchasing decisions of middle and high-income groups in urban India. However, each corporate retail store has its own model of retailing. Storing different varieties of products at same locality, location advantage, self-servicing outlets, window shopping, large scale discount, specialty stores are some of the models retailing stores have adopted. But all these retail models are not beingÂ Â popular among the consumers. Consumerâ€™s preferences and choices are varying across different retail models. In this context the present study wants to explore significant difference among corporate retail stores in Vijayawada in consumer preference and choices.Â Â