bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthcare system barriers of breast and thyroid screening for childhood and young adulthood cancer survivors in France A qualitative study of the DeNaCaPST programme at one year
Authors: demoor-goldschmidt charlotte , berger claire , guichard isabelle , SUPIOT STEPHANE , dezellus aliette , filhon bruno , bondiau piere-yves , poiree maryline , oudot caroline , claude line , truc gilles , briandet claire , padovani laetitia , coze carole , bernier valerie , kerr christine , reguerre yves , sudour-bonnange helene , gaudichon jeremie , vigneron celine , dumas agnes , vathaire florent de 
Published: July 2019

Abstract
Purpose
Childhood, adolescent and young adult cancer survivors (CAYACS) who were treated by radiotherapy have a significant risk of developing subsequent malignancies, particularly breast and thyroid cancers when the field of irradiation concerned these organs. Advice regarding their increased risk of developing secondary breast (SBC) and thyroid (STC) cancer are recommended to ensure risk-stratified life-long follow-up care including appropriate screening. In France, a national program called DeNaCaPST was started to promote this care. We aimed to explore the perspectives of medical practitioners (MP) on the healthcare system factors that limited inclusion in this programme.
Methods
Data of the DeNaCAPST programme regarding organisation were studied, including data from a qualitative survey done among MP.
Results
Seventeen months after the DeNaCaPST programme started, 84.6% of the French regions had participating centres/hospitals, along with one overseas territory. The main barriers to screening highlighted by MP were: 1) inconvenient and under-resourced healthcare professionals to perform these consultations, (2) difficulty determining which CAYACS need SBC and/or STC screening, (3) difficulty organising the network of professionals from paediatric to adult health services.
Conclusions
Despite a slow inclusion speed and a suboptimal geographical coverage, changes are underway and should allow for several improvements and interesting perspectives for this study. CAYACS lost to follow-up are difficult to invite for a consultation. The absence of real long-term follow-up care is a real barrier to promoting such screening, which must involve a transition care between the paediatric oncologists who know who are at risk and why and the adult medical professionals who have the knowledge to do the screening. The involvement and empowerment of CAYACS is necessary to promote patient-centred healthcare solutions and seems feasible.
Effect of water temperature on occurrence of Edwardsiella tarda in olive flounder Paralichthys olivaceus farms in Jeju island, South Korea
Authors: Yoo Juri , Han Sori , Hong Jimin , Kang Bo-Kwang , Phuong Mai Thi , Lee Woo-Jai , Munang'andu Hetron Mweemba , Kim Sung-Hyun 
Published: July 2019

Abstract
Objective: Edwardsiellosis is an important disease associated with high economic losses in aquaculture. In the present study we wanted to determine whether occurrence of Edwardsiella tarda infections in Olive flounder (Paralichthys olivaceus) correspond with changes in water temperature on fish farms in Jeju island, South Korea.
Results: In 2017, the number of cases were highest in August and September reaching up to 70% of the sampled fish when the average monthly water temperature was highest at 21.7°C. The number of cases declined to <5% during the cold months of January to March when the mean monthly water temperatures were lowest varying between 15.6°C and 16.4°C in 2017. However, the number of cases in 2018 where lower than in 2017 despite the average annual temperature for both years being equal at 18.2°C. Interestingly, the number of cases observed in the first three months of 2019 corresponded with cases observed in 2017 during the first three months when the average water monthly temperature was 16.4°C and 15.2°C. Data presented herein could be useful in understanding the effect of water temperature on occurrence of E. tarda infection leading to developing intervention control measures against E. tarda infections in aquaculture.
Hepatitis B Prevalence among Pregnant Women in Central and West Nile regions of Uganda: Is there a Need to prioritize Prevention of Mother to Child hepatitis B transmission?
Authors: Nankya-Mutyoba Joan , Aizire Jim , Makumbi Fredrick , Atuyambe Lynn , Kirk Gregory , Ocama Ponsiano 
Published: July 2019

Abstract
Introduction

Within sub-Saharan Africa (SSA), the burden of chronic hepatitis B (HBV) is unacceptably high in several countries including Uganda. Elimination of HBV in the context of inadequate resources and several competing health issues, faces challenges including limited data on disease burden in important population sub-groups. In order to optimize available resources, reliable data on HBV among pregnant women is useful to guide policies on prevention. This study estimated HBV prevalence and related factors among pregnant women in Central and West Nile regions of Uganda

Methods

Using a two-stage sampling approach, we selected a random sample of 310 pregnant women, 18 years or older from public health facility antenatal clinics in central and west Nile, North-western Uganda. Consenting women were interviewed to obtain data on HBV vaccination status, HIV status, selected sexual and lifestyle factors and socio-demographic information. In addition, they underwent phlebotomy to obtain blood for testing for hepatitis B surface antigen, (HBsAg) antibodies to the surface antigen (anti-HBs), and antibodies to the core (anti-HBc), as indicators of chronic infection, prior exposure, and susceptibility (anti-HBs <10 mIU /mL), respectively.

Results

Out of 310 women, prevalence of chronic HBV infection was 6.2%. Prevalence in the West Nile region was notably higher than in the Central region (11.0% vs. 1.3%), p<0.001. In both regions, majority of pregnant women (61% West Nile region, 76% Central region) were still susceptible to HBV. Overall, proportion who had been tested for HBV and those who reported having been vaccinated was only 5.8% and 11.3% respectively.

Conclusion

Our findings reveal the burden of HBV in Ugandan pregnant women is still high, with marked regional differences in disease prevalence, and poor levels of HBV testing and vaccination. These data suggest that HBV prevention programs and policies in resource-limited settings like Uganda may need to consider the differential HBV prevalence, as optimizing HBV prevention services in higher prevalence regions may provide greater impact and thereby align with the WHO recommendation on HBV elimination strategy in SSA.
Epidemiology of Dermatophytes and Non Dermatophyte Molds among Patients Attending Rank Higher Specialized Dermatology Clinic, Addis Ababa, Ethiopia
Authors: Araya Shambel , Tesfaye Betelhem , Fente Desalegn 
Published: July 2019

Abstract
Background: Dermatophytes are keratinophilic fungi that infect keratinized tissues causing diseases known as dermatophytosis. Dermatophytosis is common worldwide and continues to increase.
Objective: This study was undertaken to determine the prevalence of dermatophytes and the spectrum of fungal agents in patients attending Rank higher clinic.
Methods: a cross sectional study has been conducted, in which 318 Samples were collected from patient’s hair, nail and skin. A portion of each sample was examined microscopically and the remaining portion of each sample was cultured onto plates of Sabouraud’s dextrose agar containing chloramphenicol with and without cycloheximide. Dermatophyte isolates were identified by studying macroscopic and microscopic characteristics of their colonies.
Result: Of 318 samples, fungi were detected in 133 (54.4%) by direct wet mount while 148/315(46.5%) of them were culture positive. From these 72/148(46.8 %) were dermatophytes. Among dermatophyte isolates T. tonsurans 29/72(40.2%) was the most common cause of infection. Tinea capitis was the predominant clinical manifestation accounting for 170/315(53.4%) of the cases. Patients with age group 1-14 years were more affected. T. tonsurans was the most common pathogen in tinea capitis, whereas T. mentagrophytes was the most common pathogen in tinea corporis.
Conclusion: In this study the prevalence of dermatophytes were higher. Further intensive epidemiological studies of dermatophytes induced dermatophytosis which have public health significance are needed.
Key words: Dermatophytes, Non dermatophytes, Dermatophytosis, fungi
MEMAHAMI KAITAN OBESITAS DAN KANKER: PELUANG UNTUK PENCEGAHAN KANKER
Authors: Wargasetia Teresa Liliana 
Published: July 2019

Jumlah kasus kanker yang disebabkan oleh obesitas diperkirakan sebesar
20%. The International Agency for Research into Cancer dan the World Cancer
Research Fund melaporkan bahwa kanker yang sering dialami oleh penderita
obesitas adalah kanker endometrium, adenokarsinoma esofagus, kolorektal,
payudara postmenopause, prostat, dan ginjal. Risiko keganasan yang meningkat
dipengaruhi distribusi lemak tubuh dan peningkatan berat badan yang
menyebabkan transfer lipid dari adiposit ke tumor. Sejumlah studi melaporkan
bahwa kelebihan berat badan dan obesitas berkorelasi dengan tingkat kematian
akibat kanker hepar, pankreas, kolon, endometrium, ginjal, payudara
postmenopause, mieloma, dan Hodgkin’s lymphoma. Empat sistem yang
teridentifikasi sebagai penyebab kanker pada obesitas adalah peningkatan lipid,
respons inflamasi, resistensi insulin, dan adipokin. Konsumsi sejumlah makanan
yang bersifat antikanker dan antiobesitas bersama dengan restriksi kalori dan
aktivitas fisik membantu dalam pencegahan kanker yang berkaitan dengan
obesitas.
ANALISIS KEUANGAN TERHADAP KELAYAKAN INVESTASI LABORATORIUM ANGIOGRAFI RUMAH SAKIT BETHESDA YOGYAKARTA
Authors: Al Hadri Cecilia Farrona , Probandari Ari Natalia , Pinzon Rizaldi Taslim 
Published: July 2019

Latar Belakan: kematian akibat PTM (Penyakit Tidak Menular)
diperkirakan akan terus meningkat di seluruh dunia, peningkatan terbesar akan
terjadi di negara-negara berkembang. Mempertahankan konsumen dan berusaha
mendapatkan konsumen baru merupakan strategi wajib yang harus di jalankan
oleh rumah sakit. Keberadaan konsumen sangat penting bagi bisnis rumah sakit
karena konsumen merupakan roda bisnis rumah sakit. Rumah Sakit Bethesda
Yogyakarta, berencana untuk melakukan investasi laboratorium Angiografi untuk
menunjang fasilitas kesehatan yang sudah ada. Sebelum melakukan investasi
penting untuk mengetahui berapa besar unit cost dan tarif yang akan ditetapkan
selain itu juga perlu diketahui kemauan membayar (Willingness to Pay) dan
kemampuan membayar (Ability to Pay) pasien terhadap penggunaan layanan.
Metode Penelitian: penelitian dilakukan dengan menggunakan rancangan
studi kasus yang dilakukan di Rumah Sakit Bethesda Yogyakarta. Sebanyak 265
orang dipilih sebagai responden, yang diambil dari poliklinik saraf dan penyakit
dalam. Data primer terdiri dari data kemauan dan kemampuan pasien untuk
melakukan pelayanan laboratorium angiografi. Data sekunder di dapatkan dari
rumah sakit, penelitian terdahulu dan lainnya. Analisis investasi dihitung
menggunakan Net Present Value, Internal Ratr of Return, payback Period dan
Return On Investment.
Hasil: Perhitungan dengan menggunakan analisis Net Present Value
menghasilkan nilai sebesar Rp.23.569.363.711,-. Jika dibandingkan dengan nilai
modal, NPV bernilai positif sehingga investasi ini layak dilaksanakan. Analisis
Internal Rate of Return menghasilkan nilai 29% yang berarti lebih besar dari faktor
diskonto artinya dengan menggunakan analisis ini investasi juga layak dilakukan.
Perhitungan menggunakan Payback Period diketahui masa balik modal investasi
laboratorium angiografi adalah selama tiga tahun tujuh bulan dan Return On
Invesment menunjukkan pelayanan laboratrium angiografi berkemampuan untuk
menghasilkan laba sebesar 120%.
Kesimpulan: hasil penelitian menunjukkan investasi laboratorium
angiografi dari aspek keuangan layak dilakukan. Kemauan masyarakat untuk
menggunakan layanan cukup tinggi namun dari segi kemampuan rata-rata masih
rendah.
TRANSCRANIAL DOPPLER PADA SEREBRAL ARTERIOVENOUS MALFORMATION LAPORAN KASUS
Authors: Pramudita Esdras Ardi 
Published: July 2019

Serebral Arteriovenous Malformation (AVM) merupakan suatu kelainan pada
formasi pembuluh darah di otak. Keadaan dinding pembuluh darah yang
terbentuk pada AVM tidak sebaik dengan pembuluh darah normal sehingga
mudah pecah dan menimbulkan masalah intraserebral. TCD merupakan suatu
pemeriksaan berbasis ultrasound yang bersifat non invasif, murah dan real time
dalam memeriksa kondisi hemodinamik intraserebral dan TCD dapat digunakan
untuk menentukan feeder artery pada serebral AVM. Melaporkan dua kasus
Serebral AVM selama bulan Juli-September 2016 di RS Panti Rapih Yogyakarta
dari kedua kasus didapatkan peningkatan Mean Flow Velocity (MFV) dan
penurunan Pulsatility Index (PI) <0,5 pada Right Anterior Cerebral Artery (R-ACA)
dari kasus pertama dan Left Middle Cerebral Artery (L-MCA) dari kasus kedua yang
menunjukkan bahwa arteri-arteri ini sebagai feeder artery
DAKWAH POLITIK NABI MUHAMMAD SAW MELALUI SURAT KEPADA RAJA HERAKLIUS, KISRA ABRAWAIZ, MUQAUQIS, DAN NAJASYI
Authors: Nurul Insani Agusti Alfi 
Published: July 2019

<p>Da'wah must be carried out using the right approach. Among the da'wah approaches is a political approach, called political da’wah. The practice of political da'wah has been exemplified by the Prophet Muhammad in the form of sending da'wah to rulers outside of Islamic rule. In this article, the author discusses the political da’wah of the Prophet Muhammad through a letter to four rulers, namely Heraclius, Kisra Abrawaiz, Muqauqis, and Najasyi. This study concluded that the Prophet Muhammad's political da'wah was a form of the head of state's political da'wah to the head of state. The da'wah method used is writing da'wah (da'wah bi al-qalam) through diplomacy strategies using letter media. Systematic of letters include the beginning of letters, letterhead, topic switching, contents of letters, and letter<br />stamps. The Prophet Muhammad's letter contained an invitation to convert to Islam, good news (tabsyir), warning (tandzir), and also the verses of the Qur'an.<br /> <br /><br /></p>
STRATEGI DAKWAH MASYARAKAT SAMIN
Authors: Hidayah Lutfi 
Published: July 2019

<p>The life of the Samin community has undergone many changes and shifts since they embraced Islam. This paper examines the strategy of implementing da'wah to their community. The implementation of Islamic da'wah has existed among them, which can be seen from Islamic nuances, carried out by Fatayat, Muslimat, TPQ, the Hadrah Art group, and the Selapanan Recitation group. The activity became a forum for the development of Islamic teachings among the community. This paper concludes that the da'wah strategy used by the Samin community is the strategy of preaching bi al-hikmah, namely preaching by looking at the situation and condition of them first so that they do not feel compelled or objected to accepting and implementing Islamic teachings. This strategy is quite appropriate to be applied, because before delivering da'wah, da'i already knew the situation and conditions of them. Through the da'wah strategy mentioned above, they can receive da'wah well so that it has a positive impact on their lives.</p><p> </p>
Synthesis and Assessment of 3-Substituted Phenazines as Novel Antichlamydial Agents
Authors: Bao Xiaofeng , Liu Ziyi , Ni Min , Xia Chao , Xu Shunxin , Yang Shengju , Zhao Yu 
Published: July 2019

Background:
In the past century, many phenazines were isolated from the marine microorganism,
and some of these phenazines possessed potent antibacterial activities. We found that
a few of the synthesized 4-substituted phenazines could block the infectivity of chlamydiae without
host cell toxicity.

Objective:
The aim of this study was to design and synthesize two series of novel 3-substituted
phenazines to find novel antichlamydial agents.

Methods:
The 3-substituted phenazines were synthesized via Buchwald-Hartwig cross coupling
reaction and Suzuki reaction from 3-bromo-1-methoxyphenazine. The antichlamydial activity of
these synthesized compounds was evaluated by determining their effect on the yield of infectious
progeny EBs. Cytotoxicity of these compounds on host cells was assessed by the treatment of uninfected
HeLa cells using WST-1 method.

Results:
Most of the 3-substituted phenazines possessed potent antichlamydial activity with IC50
values from 0.15 to 12.08 μM against Chlamydia trachomatis L2, C. muridarum MoPn and C.
pneumoniae AR39. Among them, 7d and 9a exhibited better antichlamydial activity with IC50 values
from 0.20 to 1.01 μM while they have no apparent cytotoxicity to host cells. Biological assay
disclosed that both 7d and 9a inhibited chlamydial infection by reducing elementary body infectivity
and disturbing chlamydial growth during the whole chlamydial developmental cycle.

Conclusion:
Our findings suggested that 3-substituted phenazine derivatives might be a promising
class of therapeutic agents for chlamydial infections. More effective phenazines with low toxicity
could be acquired through further chemical modification on C-3 position rather than C-4 position
of phenazine.
Schistosomal Sulfotransferase Interaction with Oxamniquine Involves Hybrid Mechanism of Induced-fit and Conformational Selection
Authors: Ezebuo Fortunatus C. , Uzochukwu Ikemefuna C. 
Published: July 2019

Background:Sulfotransferase family comprises key enzymes involved in drug metabolism. Oxamniquine is a pro-drug converted into its active form by schistosomal sulfotransferase. The conformational dynamics of side-chain amino acid residues at the binding site of schistosomal sulfotransferase towards activation of oxamniquine has not received attention.Objective:The study investigated the conformational dynamics of binding site residues in free and oxamniquine bound schistosomal sulfotransferase systems and their contribution to the mechanism of oxamniquine activation by schistosomal sulfotransferase using molecular dynamics simulations and binding energy calculations.Methods:Schistosomal sulfotransferase was obtained from Protein Data Bank and both the free and oxamniquine bound forms were subjected to molecular dynamics simulations using GROMACS-4.5.5 after modeling it’s missing amino acid residues with SWISS-MODEL. Amino acid residues at its binding site for oxamniquine was determined and used for Principal Component Analysis and calculations of side-chain dihedrals. In addition, binding energy of the oxamniquine bound system was calculated using g_MMPBSA.Results:The results showed that binding site amino acid residues in free and oxamniquine bound sulfotransferase sampled different conformational space involving several rotameric states. Importantly, Phe45, Ile145 and Leu241 generated newly induced conformations, whereas Phe41 exhibited shift in equilibrium of its conformational distribution. In addition, the result showed binding energy of -130.091 ± 8.800 KJ/mol and Phe45 contributed -9.8576 KJ/mol.Conclusion:The results showed that schistosomal sulfotransferase binds oxamniquine by relying on hybrid mechanism of induced fit and conformational selection models. The findings offer new insight into sulfotransferase engineering and design of new drugs that target sulfotransferase.
ESM-1: A Novel Tumor Biomaker and its Research Advances
Authors: Li Chen , Geng Hui , Ji Linhua , Ma Xiaojing , Yin Qichao , Xiong Hua 
Published: July 2019

Background:Cancer kills nearly 9,000,000 people worldwide, and its mortality was reported up to 28% in the past decade. Few available tumor markers have been known to help early stage diagnosis. In this study, Endocan was taken as a novel tumor marker, which has been found in many cancers related to cancer cell proliferation, neoangiogenesis, etc.Methods:Studies on Endocan and its correlation with cancer were reviewed, and key points of meaningful studies on the structure, pathways and targeted agents of Endocan were drawn.Results:Endocan leads to tumorigenesis and promotes tumor cells proliferation via HGF/SF signal transmission pathway, suppresses tumor cells apoptosis via NF-κB signaling pathway and promotes angiogenesis within tumors via VEGF and HIF pathway. Medicine suppressing the expression of Endocan could prevent tumorigenesis and even improve survival rate of mice with tumor significantly.Conclusion:Endocan is capable of promoting prognosis of cancer patients. Moreover, Endocan is supposed to a potential target of tumor-targeted therapy.
A Context-Specific Training Programme for Home Based Carers Who Care for People With Diabetes: A Necessity at Ga-Dikgale Village in South Africa
Authors: Bopape Mamare A. , Mothiba Tebogo. M. , Bastiaens Hilde 
Published: July 2019

Introduction:
South Africa, like many countries, has been experiencing an increase in the prevalence of Type 2 Diabetes Mellitus (T2DM) and is amongst the top five countries with a high number of diabetes mellitus cases. Home Based Carers (HBCs) have been involved in the care of people with diabetes because of the need for efficient and cost-effective use of healthcare resources, especially in low-income countries. Previous research showed that HBCs are insufficiently trained in T2DM which leads to low-quality care but also disrespect by patients towards HBCs. The aim of this article was to develop a training program necessary for HBCs who care for People With Diabetes (PWD).

Methods:
Mixed method was used for the main study and both qualitative and quantitative data were collected to serve as a base for this phase. ADDIE model was used to guide the development of the training programme for HBCs.

Results and Discussion:
A context-specific training programme consisting of three modules was developed: (1) Basic knowledge and classification of diabetes mellitus, (2) prevention and control of diabetes and (3) management of diabetes and prevention of complications by HBCs. Development of the training programme was necessary because its availability and training of HBCs will increase disease-specific knowledge.

Conclusion:
This is the first training programme developed for HBCs in this region to address diabetes knowledge training gaps. The training programme might be of assistance to other researchers who may want to train HBCs in their regions.