bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients
Authors: Migliorini Denis , Dutoit Valérie , Allard Mathilde , Grandjean Hallez Nicole , Marinari Eliana , Widmer Valérie , Philippin Géraldine , Corlazzoli Francesca , Gustave Robin , Kreutzfeldt Mario , Blazek Nathalie , Wasem Joëlle , Hottinger Andreas , Koka Avinash , Momjian Shahan , Lobrinus Alexander , Merkler Doron , Vargas Maria-Isabel , Walker Paul R , Patrikidou Anna , Dietrich Pierre-Yves 
Published: February 2019

Abstract

Background
Peptide vaccines offer the opportunity to elicit glioma-specific T cells with tumor killing ability. Using antigens eluted from the surface of glioblastoma samples, we designed a phase I/II study to test safety and immunogenicity of the IMA950 multipeptide vaccine adjuvanted with poly-ICLC (polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose) in human leukocyte antigen A2+ glioma patients.

Methods
Adult patients with newly diagnosed glioblastoma (n = 16) and grade III astrocytoma (n = 3) were treated with radiochemotherapy followed by IMA950/poly-ICLC vaccination. The first 6 patients received IMA950 (9 major histocompatibility complex [MHC] class I and 2 MHC class II peptides) intradermally and poly-ICLC intramuscularly (i.m.). After protocol amendment, IMA950 and poly-ICLC were mixed and injected subcutaneously (n = 7) or i.m. (n = 6). Primary endpoints were safety and immunogenicity. Secondary endpoints were overall survival, progression-free survival at 6 and 9 months, and vaccine-specific peripheral cluster of differentiation (CD)4 and CD8 T-cell responses.

Results
The IMA950/poly-ICLC vaccine was safe and well tolerated. Four patients presented cerebral edema with rapid recovery. For the first 6 patients, vaccine-induced CD8 T-cell responses were restricted to a single peptide and CD4 responses were absent. After optimization of vaccine formulation, we observed multipeptide CD8 and sustained T helper 1 CD4 T-cell responses. For the entire cohort, CD8 T-cell responses to a single or multiple peptides were observed in 63.2% and 36.8% of patients, respectively. Median overall survival was 19 months for glioblastoma patients.

Conclusion
We provide, in a clinical trial, using cell surface-presented antigens, insights into optimization of vaccines generating effector T cells for glioma patients.

Trial registration
Clinicaltrials.gov NCT01920191.
Comparison of Motor Outcome in Patients Undergoing Awake vs General Anesthesia Surgery for Brain Tumors Located Within or Adjacent to the Motor Pathways
Authors: Zelitzki Roni , Korn Akiva , Arial Eti , Ben-Harosh Carmit , Ram Zvi , Grossman Rachel 
Published: February 2019

Abstract

BACKGROUND
Surgical removal of intra-axial brain tumors aims at maximal tumor resection while preserving function. The potential benefit of awake craniotomy over craniotomy under general anesthesia (GA) for motor preservation is yet unknown.

OBJECTIVE
To compare the clinical outcomes of patients who underwent surgery for perirolandic tumors while either awake or under GA.

METHODS
Between 2004 and 2015, 1126 patients underwent surgical resection of newly diagnosed intra-axial tumors in a single institution. Data from 85 patients (44 awake, 41 GA) with full dataset who underwent resections for perirolandic tumors were retrospectively analyzed.

RESULTS
Identification of the motor cortex required significantly higher stimulation thresholds in anesthetized patients (9.1 ± 4 vs 6.2 ± 2.7 mA for awake patients, P = .0008). There was no group difference in the subcortical threshold for motor response used to assess the proximity of the lesion to the corticospinal (pyramidal) tract. High-grade gliomas were the most commonly treated pathology. The extent of resection and residual tumor volume were not different between groups. Postoperative motor deficits were more common in the anesthetized patients at 1 wk (P = .046), but no difference between the groups was detected at 3 mo. Patients in the GA group had a longer mean length of hospitalization (10.3 vs 6.7 d for the awake group, P = .003).

CONCLUSION
Awake craniotomy results in a better early postoperative motor outcome and shorter hospitalization compared with patients who underwent the same surgery under GA. The finding of higher cortical thresholds for the identification of the motor cortex in anesthetized patients may suggest an inhibitory effect of anesthetic agents on motor function.
Papillary Tumor of the Pineal Region: Systematic Review and Analysis of Prognostic Factors
Authors: Yamaki Vitor Nagai , Solla Davi Jorge Fontoura , Ribeiro Renan Ribeiro , da Silva Saul Almeida , Teixeira Manoel Jacobsen , Figueiredo Eberval Gadelha 
Published: February 2019

Abstract

BACKGROUND
Clinical outcomes and biological behavior of papillary tumors of the pineal region (PTPR) are still under investigation. The best therapeutic strategy has not been defined.

OBJECTIVE
To perform a comprehensive patient-level analysis of all PTPR cases and identify their clinical features, treatment options, and prognostic factors.

METHODS
A search of the medical databases for case series and reports on PTPRs from January 2003 to June 2017 was performed. Data addressing PTPR’s clinical presentation, imaging, treatment, and histological features were. Variables associated with the primary outcome of 36-mo survival were identified through Cox regression models.

RESULTS
The initial search yielded 1164 studies, of which 71 were included (60 case reports and 11 case series), containing 177 patients (mean age 33.0 ± 15.3 yr and 53.2% male). Intracranial hypertension and hydrocephalus prevailed as the clinical picture. Surgery was performed on 82.0% and gross total resection (GTR) was achieved on 71.4%. A total of 56.8% recurred after a median 29 mo (quartiles 10.5-45.5). The 36-mo survival rate was 83.5% (95% confidence interval [CI] 76.2-89.2%). Good functional outcomes (Glasgow Outcome Scale 4/5) were observed in 60.0%. The variables of interest were inconsistently reported and the multivariable analysis final sample was 133 patients. After adjustment for age, tumor size (each additional centimeter, hazard ratio [HR] 1.99, 95% CI 1.12-3.53, P = .019) and surgical treatment (HR 0.16, 95% CI 0.05-0.45, P = .001) were associated with 36-mo survival.

CONCLUSION
Tumor size and surgery are associated with improvement in 36-mo survival. We did not observe any significant benefits from GTR or adjuvant treatments.
How central bankers learned to love financialization: The Fed, the Bank, and the enlisting of unfettered markets in the conduct of monetary policy
Authors: Walter Timo , Wansleben Leon 
Published: February 2019

AbstractCentral banks’ role in financialization has received increasing attention in recent years. These debates have predominantly revolved around authorities’ ‘benign neglect’ of asset bubbles, their deregulatory policies, and the safety nets they provide for speculative exuberance. Most analyses refer to the dominance of pro-market interests and ideas to explain these actions. The present article moves beyond these accounts by showing how an alignment between techniques of monetary governance and ‘unfettered’ financial markets can explain central banks’ endorsement of increasingly fragile structures of liquidity and their strategic ignorance towards growing amounts of debt. We analyze the processes of abstraction and formalization by which the ‘programmes’ and ‘technologies’ of monetary governance have been made compatible with the texture of contemporary finance; and we show how central banks’ attempts to make markets more amenable to their methods of policy implementation shaped new conduits for financial growth. As empirical cases, we discuss the Federal Reserve’s experiments with different policy frameworks in the 1980s and the Bank of England’s twisted path to inflation targeting from 1979 to 1997. These cases allow us to demonstrate that the infrastructural power of contemporary central banking is predicated on the same institutional foundations that have made financialization possible.
Deindustrialization, the Linwood Car Plant and Scotland’s Political Divergence from England in the 1960s and 1970s
Authors: Phillips Jim , Wright Valerie , Tomlinson Jim 
Published: February 2019

Abstract
Scotland’s political divergence from England is a key theme in late twentieth century British history. Typically seen in terms of the post-1979 Thatcher effect, this in fact developed over a longer timeframe, rooted in industrial changes revealed by analysis of the Linwood car plant in Renfrewshire. Conservatism and Unionism was an eminent political force in Scotland in the 1940s and 1950s. But in all general elections from 1959 onwards the vote share of Conservative and Unionist candidates was lower in Scotland than in England. From the late 1960s onwards there were also ambitions for constitutional change. This article breaks new conceptual and empirical ground by relating these important markers of political divergence to popular understanding among Scottish workers of deindustrialization. A Thompsonian moral economy framework is deployed. Expectations were elevated by industrial restructuring from the 1950s, with workers exchanging jobs in the staples for a better future in assembly goods. Labour governments earned a reputation in Scotland as better managers of this process than Conservative governments. The 1979 general election showed that Labourism was growing in popularity in Scotland just as its appeal faded in England. At Linwood moral economy expectations were compromised, chiefly by intermittent redundancy and recurrent threat of closure, which was averted in 1975 by Labour government intervention. When the plant was shut in 1981 criticisms of UK political-constitutional structures and Conservativism were intensified.
A physiological approach to the ecology and evolution of flowers
Authors: Roddy Adam B. 
Published: February 2019

AbstractFor most angiosperms, flowers are critical to reproduction because they increase rates of outcrossing. Flowers are highly variable in numerous traits, including size, shape, and color. Most of this variation is thought to have arisen due to selection by pollinators. Yet, non-pollinator selection is increasingly being recognized as contributing to floral trait evolution. One such non-pollinator agent of selection that often opposes pollinator selection includes the physiological and resource costs of producing and maintaining flowers. Yet, our understanding of the physiological function of flowers remains limited. Here I argue for a comparative, physiological framework for studying flowers and highlight recent work elucidating some of the basic physiological structure-function relationships of flowers and apply an energy balance model to show how two pollination traits (flower size and flower color) can interact with physiological traits. This modeling shows that (1) physiologically meaningful estimates of flower size can be easily gleaned from available floras, (2) the range of flower size most common in the California flora is the range in which complex, non-linear dynamics in flower energy balance occur, and (3) that intraspecific variation in flower color can, by these conservative estimates, cause large (up to 8°C) changes in flower temperature. The strong interaction between pollination traits (flower size and color) and physiological traits (surface conductance to water vapor) suggests that a more unified framework for understanding the evolution of floral form and function would include physiological traits that represent the costs of flower production and maintenance.
A novel algorithm for the collective integration of single cell RNA-seq during embryogenesis
Authors: Gong Wuming , Singh Bhairab N. , Shah Pruthvi , Das Satyabrata , Theisen Joshua , Chan Sunny , Kyba Michael , Garry Mary G. , Yannopoulos Demetris , Pan Wei , Garry Daniel J. 
Published: February 2019

AbstractSingle cell RNA-seq (scRNA-seq) over specified time periods has been widely used to dissect the cell populations during mammalian embryogenesis. Integrating such scRNA-seq data from different developmental stages and from different laboratories is critical to comprehensively define and understand the molecular dynamics and systematically reconstruct the lineage trajectories. Here, we describe a novel algorithm to integrate heterogenous temporal scRNA-seq datasets and to preserve the global developmental trajectories. We applied this algorithm and approach to integrate 3,387 single cells from seven heterogenous temporal scRNA-seq datasets, and reconstructed the cell atlas of early mouse cardiovascular development from E6.5 to E9.5. Using this integrated atlas, we identified an Etv2 downstream target, Ebf1, as an important transcription factor for mouse endothelial development.
The soft power and paradiplomacy of Hong Kong
Authors: Chan Wai Yin 
Published: February 2019

PurposeThe purpose of this paper is to map out the connection between paradiplomacy, policy instruments and soft power and propose a theoretical framework for consideration.Design/methodology/approachThis research adopted a qualitative research approach involving in-depth interviews with government officials from the Hong Kong Economic and Trade Offices and two Hong Kong film directors.FindingsThe research has discovered that the government of Hong Kong Special Administrative Region (HKSAR) lacks a holistic strategy and policy to boost Hong Kong’s visibility in the global context. The HKSAR Government exhibits an incomplete understanding of the concept of soft power and ignores the values cherished in the civil society.Practical implicationsThis investigation provides a background against which Hong Kong’s policymakers could devise a paradiplomatic strategy. This study suggests that political and social actors in Hong Kong must help to strengthen the city’s global position through strategic investments and the deployment of its soft power at home and aboard. The paradiplomacy of Hong Kong can serve as one of the effective tools to improve the legitimacy of “One Country, Two Systems.”Originality/valueThere is no study on the application of soft power under the framework of paradiplomacy. This paper represents a new direction of research in the area of Hong Kong, international status and its external affairs.
Building sustainability and innovation in organizations
Authors: Lazaretti Kellen , Giotto Olivo Tiago , Sehnem Simone , Bencke Fernando Fantoni 
Published: February 2019

PurposeThe purpose of this paper is to present the results of a systematic literature review on innovation and sustainability. To accomplish this aim, a systematic analysis of the literature in the Scopus database was carried out for articles with the terms “innovation” and “sustainability” in their titles. Once identified, articles were analyzed in three ways: the ten most-cited articles; the ten most-cited literature reviews; and the most recent articles. Sustainable development is the central theme of the articles studied. Sustainable development is influenced by the ways that sustainability is measured within the network of which the organizations are a part, including adequate systems, and is mediated by compatible behaviors. Encouraging green innovation is an environmental commitment and managerial concern driven by customer pressure, environmental regulations and cost reductions. Suppliers and customers can contribute or benefit from the value created.Design/methodology/approachThis study was a Systematic literature review. The search terms “Innov * AND sustain *” were defined for the titles of the articles. The analysis was divided into three categories: the ten most-cited articles (without a year filter to form an idea of the impact of the main research in the field); the ten most-cited reviews (these were only filtered from 2009 to 2018); and the 10 most recent articles (all of the articles found were from the year 2018).FindingsThe main findings of this study were that network action, mobilization of relevant stakeholders, reinvention of the business model, redefinition with multiple values and a sustainable strategic scope are the mechanisms that effectively contribute to promoting the link between innovation and sustainability in organizations. Sustainable development is the central theme of the articles studied. Sustainable development is influenced by the ways that sustainability is measured within the network of which the organizations are a part of, including adequate systems, and is mediated by compatible behaviors.Originality/valueThis study contributes to the literature by providing perspectives for future studies that may contribute to the sustainable development of organizations. Sustainable development is strongly influenced by the ways that sustainability is measured within the network of which the organizations are part, including appropriate systems, and is mediated by compatible behaviors.
Time management: skills to learn and put into practice
Authors: Alvarez Sainz María , Ferrero Ana M. , Ugidos Arantza 
Published: February 2019

PurposeThe knowledge society determines a work scenario in which it is essential to manage time efficiently; a non-innate skill that should be learned at the university. The paper aims to discuss this issue.Design/methodology/approachThis research analyzes the attitude, habits and time management of the Economics and Business students of the UPV/EHU, in order to propose/design/specific activities for its achievement. Through a self-administered questionnaire, the sample data are obtained, which are analyzed at a descriptive and multivariate level.FindingsThe decisive factor is not the amount of time available but the management that is made of it. In general, students pay attention to short-term planning and lack habits and attitudes in the long term.Practical implicationsUnaware of the advantages of a correct use of time, students do not develop skills such as self-organization, prioritization of objectives and activities, etc., which is why the intervention of the educational system is necessary in order to develop this skill.Originality/valueThis study focuses on the importance of developing skills, beyond the strictly technical, essential in professional performance regardless of the function assigned in the organizational chart/organization. It is about assessing time management as an integral part of higher education, competence expressed on paper, but not developed in practice. The originality and novelty of this research consists of defining new dimensions of time management and proposing some specific actions to be implemented to get a better time management.
“Walking on egg shells”: Brexit, British values and educational space
Authors: Farrell Francis 
Published: February 2019

PurposeThe purpose of this paper is to critically explore and foreground secondary religious education (RE) student teachers’ accounts of the dilemmas they experienced in their classrooms and schools in a highly racialised post referendum environment. Teacher narratives are analysed in order to suggest ways in which a transformative teaching and learning agenda drawing from a pluralistic human rights framework can be reasserted in place of government requirements to promote fundamental British values (FBV).Design/methodology/approachQualitative data were collected in focus group interviews to gain insights into how the referendum environment was experienced phenomenologically in localised school settings.FindingsThe interview data reveals the complex ways in which the discourses circulating in the post referendum milieu play out in highly contingent, diverse secondary school settings. These schools operate in a high stakes policy context, shaped by the new civic nationalism of FBV, the Prevent security agenda and government disavowal of “multiculturalism” in defence of “our way of life” (Cameron, 2011). A key finding to emerge from the teachers’ narratives is that some of the ways in which Prevent and FBV have been imposed in their schools has reduced the transformative potentials of the critical, pluralistic RE approaches to teaching and learning that is promoted within the context of their university initial teacher education programme.Research limitations/implicationsThe findings suggest that existing frameworks associated with security and civic nationalism are not sufficient to ensure that young citizens receive an education that prepares them for engagement with a post truth, post Brexit racial and political environment. Transformative teaching and learning approaches (Duckworth and Smith, 2018), drawing upon pluralistic, critical RE and human rights education are presented as more effective alternatives which recognise the dignity and agency of both teachers and students.Originality/valueThis paper is an original investigation of the impact of the Brexit referendum environment on student teachers in a university setting. In the racialised aftermath of the referendum the need for transformative pluralistic and critical educational practice has never been more urgent. The data and analysis presented in this paper offer a compelling argument for a root and branch reformulation of current government security agendas in education.
The circular economy, natural capital and resilience in tourism and hospitality
Authors: Jones Peter , Wynn Martin George 
Published: February 2019

Purpose
This paper aims to review some of the academic literature on the circular economy, natural capital and resilience by tourism and hospitality scholars and to examine how a number of companies and industry bodies within the tourism and hospitality industry have used these concepts in their business operations and development plans.

Design/methodology/approach
The paper outlines the importance of sustainability to the tourism and hospitality industry and provides definitions of the concepts of the circular economy, natural capital and resilience. The paper reviews some of the academic literature on these concepts, explores how a number of companies and industry bodies within the tourism and hospitality industry have used them in their business and planning operations and identifies a number of future directions for academic research and managerial contributions.

Findings
The concepts illuminate a range of sustainability challenges and opportunities, and some companies use these concepts in their sustainability strategies and development planning. The current depth of theoretical understanding does not lend itself to management strategies, but one fruitful avenue is to explore how information systems can be better deployed to support these concepts and sustainability management in general.

Originality/value
The paper provides an accessible exploratory review of how academics and companies are focussing on the concepts of the circular economy, natural capital and resilience in the tourism and hospitality industry. As such, it will be of interest to academics, students and practitioners interested in the hospitality industry.