bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoadjuvant Treatment With Müllerian-Inhibiting Substance Synchronizes Follicles and Enhances Superovulation Yield
Authors: Kano Motohiro , Hsu Jennifer Y , Saatcioglu Hatice D , Nagykery Nicholas , Zhang LiHua , Morris Sabatini Mary E , Donahoe Patricia K , Pépin David 
Published: August 2019

Abstract
Müllerian-inhibiting substance (MIS), also known as anti-Müllerian hormone, is thought to be a negative regulator of primordial follicle activation. We have previously reported that treatment with exogenous MIS can induce complete ovarian suppression within 5 weeks of treatment in mice. To investigate the kinetics of the return of folliculogenesis following the reversal of suppression, we treated animals with recombinant human MIS (rhMIS) protein for 40 days in adult female Nu/Nu mice and monitored the recovery of each follicle type over time. Following cessation of MIS therapy, secondary, and antral follicles returned within 30 days, along with the normalization of reproductive hormones, including LH, FSH, MIS, and Inhibin B. Furthermore, 30 days following MIS pretreatment, the number of antral follicles were significantly higher than controls, and superovulation with timed pregnant mare serum gonadotropin and human chorionic gonadotropin stimulation at this time point resulted in an approximately threefold increased yield of eggs. Use of the combined rhMIS-gonadotropin superovulation regimen in a diminished ovarian reserve (DOR) mouse model, created by 4-vinylcyclohexene dioxide treatment, also resulted in a twofold improvement in the yield of eggs. In conclusion, treatment with rhMIS can induce a reversible ovarian suppression, following which a rapid and synchronized large initial wave of growing follicles can be harnessed to enhance the response to superovulation. Therapies modulating MIS signaling may therefore augment the response to current ovarian stimulation protocols and could be particularly useful to women with DOR or poor responders to controlled ovarian hyperstimulation during in vitro fertilization.
Urinary Bisphenols and Obesity Prevalence Among U.S. Children and Adolescents
Authors: Jacobson Melanie H , Woodward Miriam , Bao Wei , Liu Buyun , Trasande Leonardo 
Published: August 2019

AbstractBisphenol A (BPA) has been recognized as an endocrine disrupting chemical and identified as an obesogen. Although once ubiquitous, human exposure to BPA has been declining owing to its substitution with other bisphenols. Two structurally similar substitutes, bisphenol S (BPS) and bisphenol F (BPF), have raised similar concerns, although fewer studies have been conducted on these newer derivatives. We used data from the US National Health and Nutrition Examination Surveys from 2013 to 2016 to evaluate associations between BPA, BPS, and BPF and body mass outcomes among children and adolescents aged 6 to 19 years. Concentrations of BPA, BPS, and BPF were measured in spot urine samples using HPLC with tandem mass spectrometry. General obesity was defined as ≥95th percentile of the age- and sex-standardized body mass index (BMI) z-scores according to the 2000 US norms. Abdominal obesity was defined as a waist circumference/height ratio of ≥0.5. BPA, BPS, and BPF were detected in 97.5%, 87.8%, and 55.2% of urine samples, respectively. Log-transformed urinary BPS concentrations were associated with an increased prevalence of general obesity (OR, 1.16; 95% CI, 1.02 to 1.32) and abdominal obesity (OR, 1.13; 95% CI, 1.02 to 1.27). BPF detection (vs not detected) was associated with an increased prevalence of abdominal obesity (OR, 1.29; 95% CI, 1.01 to 1.64) and continuous BMI z-score (β = 0.10; 95% CI, 0.01 to 0.20). BPA and total bisphenols were not statistically significantly associated with general obesity, abdominal obesity, or any body mass outcome. These results suggest that BPA substitute chemicals are correlated with obesity in contemporary children.
Diagnostic value of endoscopic ultrasound elastography for benign and malignant digestive system tumors
Authors: Lv Hongna , Zhu Guangchao , Zhou Long’an 
Published: August 2019

Objective: To investigate the effect of endoscopic ultrasound real-time tissue elastography in differential diagnosis of benign and malignant digestive system tumors.
Methods: Forty-two patients with solid tumors of digestive system who were admitted to our hospital between October 2017 and October 2018 were selected. All patients were diagnosed by endoscopic ultrasound real-time tissue elastography. Elastography score was used. The strain ratios (SR) of the lesion and the surrounding control tissues were measured and compared.
Results: Lesions with elastography score no more than two points were evaluated as benign, while lesions with elastography score no less than three points were evaluated as malignant. The difference of the elastography score between the benign lesion group and malignant lesion group was statistically significant (P<0.05). The sensitivity, specificity and accuracy of endoscopic ultrasound elastography in the diagnosis of malignant tumors of digestive system were 91.4%, 88.9% and 87.5%, respectively. The SR of the benign lesions ranged from 0.01 to 7.34, with a median SR of 7.33; the SR of the malignant lesions ranged from 1.01 to 47.66, with a median SR of 20.07. The SR of the benign lesions was significantly lower than that of the malignant lesions (P<0.05).
Conclusion: Elastography of benign and malignant tissues of digestive tract tumors has different image characteristics. Endoscopic ultrasound real-time tissue elastography is effective in differential diagnosis of digestive tract tumors as it can effectively determine whether a tumor is benign or malignant and improve diagnostic accuracy.
doi: https://doi.org/10.12669/pjms.35.5.1075
How to cite this:Lv H, Zhu G, Zhou L. Diagnostic value of endoscopic ultrasound elastography for benign and malignant digestive system tumors. Pak J Med Sci. 2019;35(5):1461-1465. doi: https://doi.org/10.12669/pjms.35.5.1075
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Pilgrimage Tourism: A Study on Palani Temple, Tamil Nadu
Authors: Aruljothi C , Ramaswamy S 
Published: August 2019

India is a large country with great traditions, culture, and civilization. India has 4000 years of fertile civilized life with planned cities, monumental temples, mosques and churches, palaces, sculptures, paintings and various artistic creations. These scenic beauties have made India one of the most famous tourist destinations in the world. The Tourism potential of any country mainly depends on its climate, scenery, historical monuments, arts, tradition, festivals and the society. If any place or area or spot possesses all these characters and potentials, we may call it as a tourist centre or pilgrim centre. Tamil Nadu, a southern State of India, is a land of charm with ancient traditions; the picturesque land of Tamil Nadu has towering temples with magnificent architecture and sculptures, art galleries and heterogeneous natural beauty, existing on the hills and mountains. Tamil Nadu is flooded with different cultural, spiritual and religious centres like Madurai, Rameswaram, Kanyakumari, Tanjavur, Kumbakonam, Trichy, Kancheepuram, Chidambaram, Tiruvannamalai and Palani. Religious institutions like temples in Tamil Nadu have been playing a multifaceted role in religious, social, economic and cultural life of the Tamil community. Moreover, temples are considered as producers, land owners, trustees,employers, pilgrim centres and institutions. There are studies conducted in cultural and spiritual tourism centres, which focus on heritage, culture and the historical aspects. But studies that focus on economic aspects of such centres are scanty. With this background, the authors have made an attempt to study the memories and reminiscence of 150 Pilgrimage tourists, who visited Palani Temple; one of the Six abodes of Lord Muruga located in the Dindigul district of Tamil Nadu, with an objective of examining the social and economic characteristics of the pilgrimage tourists; and identify their major problems and suggest ways and means for promoting pilgrimage tourism in Palani. The Primary data has been collected through interview schedules. The interview schedule was pre-tested, modified and well- structured, and was used for obtaining information and data from the cultural-spiritual tourists, who are visiting the Palani temple. Secondary data in connection with the Palani temple were also gathered from the office of the Commissioner, Palani temple. Further, the authors have collected data and information from 150 tourists who visited the Palani temple during June-July 2011. The tourists were purposively selected in different spots in and around the Palani temple. For the purpose of analyzing the data, simple tools like ratio, percentage and average were used
Rare health conditions 26: fatal familial insomnia, Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker syndrome
Authors: Barber Chris 
Published: August 2019

The purpose of this series is to briefly highlight a range of rare health conditions. Rare health conditions are those that affect no more and usually less than 1 person in every 2000 and many HCAs and nurses will encounter some of these conditions given the high number of these conditions. This 26th article will explore three of these rare conditions.
Elimination of gatifloxacin from water: Treatment by electro-Fenton process and highlighting of a biological post-treatment
Authors: Arhoutane Mohamed Reda , Kaichouh Ghizlan , Yahya Muna Shueai , El Karbane Miloud , Chakchak Hind , El Kacemi Kacem 
Published: August 2019

This study concerns the oxidative degradation and mineralization of gatifloxacin in aqueous solution at pH = 3 and in the presence of Fe2+ as catalyst Â using electro-Fenton (EF) process, with carbon felt as a cathode and platinum as an anode. The mineralization is evaluated by the chemical oxygen demand by assessing the applied current value and concentration of catalyst Fe2+. Some stable by-products of gatifloxacin have been identified using high-performance liquid chromatography and liquid chromatography tandem mass spectrometry. The second part of this paper concerns the study of the biodegradability in determining of BOD5/COD during the mineralization of gatifloxacin by EF in order to evaluate the possibility of coupling electro-Fenton process with the biological one. This leads to an efficient treatment of water contaminated by this antibiotic with lower cost.
Displacement-Based Simplified Calculation for Pile-Soil Interaction under Reciprocating Low-Cycle Pseudo-Static Loads
Authors: Chen Baochun , Luo Xiaoye , Huang Fuyun , Dong Rui , Xue Junqing 
Published: August 2019

Abstract
A reciprocating low-cycle pseudo-static loading test on three reinforced concrete (RC) piles was performed in the Structural Laboratory of Fuzhou University to study their failure modes and seismic behaviors. The modified calculations of lateral deformation and soil pressure along the piles were further verified based on the test results. In this article, a displacement-based simplified calculation for pile-soil interaction of piles was proposed based on the shear equilibrium and test results, and then it was compared with the traditional m method and p-y curve method. The test results show that m method overestimated the bearing capacity of piles, leading to a lower safety factor for the piles. Therefore, it was not suitable to calculate the internal force and lateral displacement under large displacement. Moreover, the ductility of prestress high-strength concrete pipe piles or RC piles would be overestimated by the p-y curve method. Although the p-y curve method took into account the nonlinearity of soil, the calculated force-lateral displacement curve still showed a significant difference with the test results under large deformation. The test results further show that the modified calculation of lateral displacement and soil pressure can be preferably validated by test results, which indicates that the displacement law of laterally loaded pile can be accurately assessed. Furthermore, the proposed displacement-based simplified calculation showed a good agreement with the test values in terms of internal forces and force-lateral displacement curve. Therefore, it was recommended for analyzing the cyclic behavior of laterally loaded pile foundations considering soil-pile interaction in integral abutments jointless bridges (IAJBs).
Autonomy Design and Operations in Aviation: Terminology and Requirements Framework
Authors:   Administrative Committee 377 (AC377), Cook Stephen , Dietrich Anna , Lacher Andrew 
Published: August 2019

Description
The aviation community has shown significant interest in adopting increasingly autonomous systems for routine use in aviation. Interest in this technology comes from the unmanned aircraft community, including those developing urban air mobility solutions and developing cognitive assistance aids leveraging mobile devices as well as those interested in simplifying small aircraft and general aviation operations and in improving aviation safety through increased automation. Increased automation moving toward autonomy has shown great promise to improve the safety of aviation and transform the industry.
The Quest for Knowledge in the “King James Bible”
Authors: Piotrowska-Oberda Ewa 
Published: August 2019

The aim of this article is the quest for knowledge in the King James Bible (1611) in terms of quantitative and qualitative research methodology with the application of the statistical analysis tool Antconc. The quest for knowledge with the use of corpus research aims at discussing the Biblical concept of knowledge through the origin, the object of knowledge, its implications and its constant development. Knowledge is often seen as of divine nature, reflected in the soul of man. It is based not only on logical, but also on the spiritual and ethical reasoning. The object of knowledge is light, reflecting the divine nature of knowledge which exceeds the intellect to reach a deeper spiritual human reasoning. In the King James Bible (1611) the authors of New Testament consider human knowledge to be imperfect and partial. They emphasize the need for a spiritual man aiming at reaching a complete knowledge. This spiritual development is based on the relationship between knowledge and faith, as well as knowledge and love.For the authors of the books of the New Testament there is no dichotomy between both knowledge and faith and knowledge and love, because faith and love depend on knowledge that originates in the word of God and leads to spiritual development. From this perspective, religious knowledge, love and mercy as well as faith developed through the knowledge of the biblical text leads to the knowledge of God, the enlightening source of ultimate knowledge. Thus, in the spiritual development of man not only the knowledge and faith but also emotional intelligence, which expresses itself through love and charity as the safer guide in all controversial issues, are important
Violent Black Man and the Myth of Black Macho in Eugene O’Neill’s “The Dreamy Kid”
Authors: Łobodziec Agnieszka 
Published: August 2019

The aim of this article is the investigation of the extent to which Eugene O’Neill, in his drama The Dreamy Kid, (re)constructs, or employs, the black macho myth, which negatively images black men as marginalized and violent. This undertaking questions O’Neill’s self-proclaimed progressive racial attitudes and stated focus on the universal nature of human existence, which he professed to express through drama. Moreover, the article challenges the mainstream view of The Dreamy Kid as progressive. Although the play focalizes the experience of a marginalized black man, which could be interpreted as the playwright’s concern with the unjust racial and class stratification of American society, O’Neill’s production, unfortunately, contains a number of pervasive stereotypes relative to black people’s alleged moral degeneracy, primitiveness, and violent behavior, which threatens the white dominated constructed order. In terms of gendered racial politics, in the article attention is given to O’Neill’s presentation of black male negotiations with the white patriarchal power structure, embodied by the police forces, and with black matriarchy, represented by O’Neill’s stereotypical character portrayal of a dominant elderly black woman. Lastly, an overall analysis is performed in light of the call for an autonomous black art, which emerged among black artists in opposition to the demeaning, unrealistic, stereotypical portrayals of black victims of oppression by white American writers.
Instrucción Ortopédica de Posgrado - Imágenes. Resolución del caso. [Post-Graduate Orthopedic Instruction: Imaging. Answer to Case Study]
Authors: Ghisi Juan Pablo , Vidondo María Emilia 
Published: August 2019

Se describe el sindrome de friccion del tendon patelar-condilo femoral, que es una entidad que ha recibido poca atención en la literatura ortopédica, y en muchas ocasiones constituye un hallazgo en las imágenes de RM sin sospecha clínica ni conocimiento de la existencia del cuadro de impingement del sector superolateral del paquete adiposo infrarotuliano de Hoffa (PAI). Es importante que se identifiquen los hallazgos característicos de las imágenes, tanto para la correcta elección del tratamiento como para distinguir esta entidad de otras causas de dolor anterior de rodilla. Si bien no existen en la actualidad respuestas definitivas con respecto a la etiología del síndrome, su identificación tiene implicaciones importantes tanto para el diagnóstico como para el tratamiento. Patellar tendon-lateral femoral condyle friction syndrome is discussed, a condition that has received little attention in orthopedic literature. In many cases, it is an incidental finding on MRI when there is no clinical suspicion or even confirmation of Hoffa fat pad impingement (FPI) syndrome. Identification of pathognomonic findings on imaging studies is key, both for selecting the adequate treatment option and to distinguish this condition from other causes of anterior knee pain. Although there is currently no definitive etiology for the syndrome, its identification is important for both diagnosis and treatment.
Small Cell and Squamous Cell Carcinomas of the Head and Neck: Comparing Incidence and Survival Trends Based on Surveillance, Epidemiology, and End Results (SEER) Data
Authors: Bean Marta B. , Liu Yuan , Jiang Renjain , Steuer Conor Ernst , Patel Mihir , McDonald Mark William , Higgins Kristin Ann , Beitler Jonathan Jay , Shin Dong Moon , Saba Nabil F. 
Published: August 2019

AbstractBackgroundSmall cell carcinomas of the head and neck (SmCCHNs) are rare neoplasms with an unfavorable prognosis. Population-based data describing survival and prognostic factors for SmCCHN are limited.MethodsData were obtained from the U.S. National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database for 1973–2013. Patient and tumor-related characteristics for SmCCHN were compared with those for squamous cell carcinoma of the head and neck (SCCHN). Survival was compared by constructing Kaplan-Meier curves and Cox proportional hazard models with and without propensity score matching.ResultsThe data set included 609 SmCCHN and 227,943 SCCHN cases. Both histological subtypes were more common in men than women and more common in white patients. SmCCHN was most likely to originate in the larynx, glottis and hypopharynx, or salivary glands and to present with more advanced stage and grade. SCCHN was most likely to originate in the oral cavity and was found infrequently in the salivary glands. Overall 5- and 10-year survival estimates were 27% and 18% for SmCCHN and 46% and 31% for SCCHN, respectively. In multivariable survival analyses adjusting for age, sex, race, marital status, year of diagnosis, stage, grade, and receipt of radiation, the hazard ratio (HR) comparing SmCCHN with SCCHN was 1.53 with a 95% confidence interval (CI) from 1.39 to 1.68. Average 5-year survival varied widely between the histologic types when comparing tumor sites: 14.5% for SmCCHN versus 48.9% for SCCHN in the oropharynx. In propensity score matched analyses, the corresponding HR was 1.27 (95% CI, 1.15–1.40).ConclusionCompared with SCCHN, SmCCHN carries a worse survival and is more likely to present with more advanced stage.Implications for PracticeSmall cell carcinoma of the head and neck (SmCCHN) is a rare subtype of head and neck cancer. In this Surveillance, Epidemiology, and End Results (SEER) data analysis, the characteristics and survival of SmCCHN are compared with those of the common squamous cell carcinoma of the head and neck. Results show that SmCCHN carries a worse prognosis and tends to present at a more advanced stage; SmCCHN also is ten times more likely to originate from the salivary glands. These findings may have implications for clinical practice, as location of the tumor may strongly associate with the pathologic diagnosis. If a SmCCHN is diagnosed, a disseminated disease is likely; hence vigilance in staging procedures is indicated.
3DMRT: A Computer Package for 3D Model‐Based Seismic Wave Propagation
Authors: Peng Pingan , Wang Liguan 
Published: August 2019

ABSTRACT
The prediction of accurate source‐to‐receiver travel times and wave paths through heterogeneous media is of major interest in global seismology and microseismic communities. Many algorithms have been proposed to address this problem, among which eikonal solvers have the best accuracy but lack computational efficiency. To facilitate the use of eikonal solvers with a high performance and visualization ability, this article presents a free, open‐source, graphical package named 3DMRT. 3DMRT propagates wavefronts through a 3D heterogeneous medium. Starting with a geologic model, the package first constructs a gridded velocity model. The application implements nine eikonal solvers and provides one‐point and multipoint raytracing functionality. In addition, 3DMRT is complemented with an additional command line tool that allows integration into other programs for further applications.
Triggering of the Pohang, Korea, Earthquake (Mw 5.5) by Enhanced Geothermal System Stimulation
Authors: Ellsworth William L. , Giardini Domenico , Townend John , Ge Shemin , Shimamoto Toshihiko 
Published: August 2019

ABSTRACT
On the afternoon of 15 November 2017, the coastal city of Pohang, Korea, was rocked by a magnitude 5.5 earthquake (Mw, U.S. Geological Survey). Questions soon arose about the possible involvement in the earthquake of the Republic of Korea’s first enhanced geothermal system (EGS) project because the epicenter of the earthquake was located near the project’s drill site. The Pohang EGS project was intended to create an artificial geothermal reservoir within low‐permeability crystalline basement by hydraulically stimulating the rock to form a connected network of fractures between two wells, PX‐1 and PX‐2, at a depth of ∼4  km. Forensic examination of the tectonic stress conditions, local geology, well drilling data, the five high‐pressure well stimulations undertaken to create the EGS reservoir, and the seismicity induced by injection produced definitive evidence that earthquakes induced by high‐pressure injection into the PX‐2 well activated a previously unmapped fault that triggered the Mw 5.5 earthquake. Important lessons of a general nature can be learned from the Pohang experience and can serve to increase the safety of future EGS projects in Korea and elsewhere.