bluuebunny/crossref_metadata_2025_split huggingface dataset:
El Problema de Ruteo e Inventarios en Cadenas de Suministro de Perecederos: Revisión de Literatura
Authors: Batero-Manso Diego Fernando , Orjuela-Castro Javier Arturo 
Published: August 2018

Context: This paper presents a literature review of the Inventories Routing Problem (IRP) applied to supply chains of perishable products. Different approaches to solve this problem are identified and described in terms of structures, models and solution methods. Method: A systematic literature review is conducted searching in different bibliographic databases and selecting the most relevant studies within the period 2004 to 2017. The results are analyzed so as to propose a taxonomy to classify and compare the different approaches proposed to address this problem.Results: We identified that the majority of studies consider heuristic-based algorithms to solve the problem. Because of its computational complexity the methods resort to metaheuristics and mateheuristics combined with exact methods. Regarding the application to specific supply chains of perishable products, they refer mostly to processed foods, medicines, and human blood. The constraints that differentiate this problem from other types of IRP are useful life and deterioration.Conclusions: The conditions and particularities of the supply chain of perishables products imply the need to consider new variables, parameters, constraints and objective functions; in the reviewed studies it is not clearly defined the differences involved when considering the perishability of the products in the supply chain. Future research should take into account the multiple ways in which deterioration is carried out with factors such as temperature, light, oxygen, humidity and in some cases microorganisms. Also include in the models the cold chain, hygiene standards, air pollution, emissions of greenhouse gases, generation of waste, occupation of roads and other aspects related to City Logistics and Green Logistics.
Świętość Kościoła w ujęciu św. Piotra Chryzologa
Authors: Kochaniewicz Bogusław 
Published: August 2018

The article Holiness of the Church according to Sermons of St. Peter Chrysologus presents one aspect of the ecclesiology of the bishop of Ravenna. Among the most popular questions, which are evidenced in his theological reflection, it is necessary to evidence, that Church Fathers focus their attention on an ontological aspect of the Church’s holiness which finds its foundation in Christ. Frequent references to ideas of the Mystical Body of Christ or the Church as a spouse of Christ confirm our opinion. It is necessary to admit that these themes, like other questions, developed in Chrysologus’s sermons (the role of the sacrament or belief that there is no salvation outside the Church) are already known in the patristic literature. Therefore the ecclesiology of the bishop of Ravenna is not original. However, taking into consideration the pastoral dimension of his teaching, it is clear that the objective of his sermons was different than to present an ecclesiological treatise.The results of analytical researches allow to complete the picture of the doctrine of the Church by its unknown aspect, contained in the teaching of the bishop of Ravenna.
DYNAMICS OF LEFT VENTRICULAR PARAMETERS IN THE LONG-TERM TREATMENT OF RENAL PARENCHYMATOUS ARTERIAL HYPERTENSION
Authors: Borovkova N. Yu. , Borovkov N. N. , Khor’kina Yu. A. , Obukhova E. O. , Arshinova A. I. 
Published: August 2018

Aim. To investigate the dynamics of left ventricular (LV) parameters during the long-term treatment of renal parenchymatous arterial hypertension (RPAH) in patients with primary chronic glomerulonephritis and preserved renal function.Material and methods. The long-term follow-up included 136 RPAH patients with preserved renal function. Clinical assessment of blood pressure (BP) levels, 24-hour BP monitoring, and Doppler echocardiography (EchoCG) were performed at baseline and during the complex antihypertensive therapy (AHT) and pathogenetic therapy of RPAH patients. The treatment-related dynamics of LV structure and function was evaluated.Results. The long-term complex treatment of RPAH patients resulted in significantly reduced clinical BP levels, improved 24-hour BPM parameters, LV hypertrophy (LVH) regression, and improved diastolic and systolic LV function.Conclusion. The long-term complex AHT, in combination with pathogenetic therapy, resulted not only in reduced BP levels and improved circadian BP profile, but also in improved diastolic and systolic LV function and LVH regression among RPAH patients with preserved renal function.
BENEFITS OF VOLUMETRIC COMPRESSION OSCILLOMETRY FOR THE ASSESSMENT OF HEMODYNAMIC PARAMETERS IN PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Shpak L. V. , Galoshina E. S. 
Published: August 2018

Aim.To compare the parameters of central and peripheral hemodynamics in healthy people and patients with Stage 1–3 arterial hypertension (AH).Material and methods.In total, 105 individuals were examined. The control group (CG) included 50 healthy people (25 women and 25 men; mean age 27,8±0,8 years) with optimal and normal levels of blood pressure (BP) (mean levels 118,5±1,6/71,82±1,2 mm Hg). The main group (MG) included 55 patients (41 women and 14 men; mean age 62,9±1,6 years) with systolo-diastolic AH: Stage 1 in 25 (mean BP levels 146,1±0,9/84,9±1,6 mm Hg), Stage 2 in 20 (164,4±1,8/95±2,1 mm Hg), and Stage 3 in 10 (189,6±10,6/92,6±6,3 mm Hg). The method of volumetric compression oscillometry (VCO) was used to assess a wide range of myocardial and hemodynamic parameters.Results.In AH patients, all AH phenotypes, vascular and cardiac parameters were increasing, with a simultaneous reduction in vascular wall distensibility, in parallel with the AH progression from Stage 1 to Stage 3. This indicated an increase in myocardial contractility, tone strain of arterial wall, and peripheral vascular resistance. From Stage 1 to Stage 3, the prevalence of hyper- and eukinetic cardiac hemodynamic types was decreasing, while the prevalence of mixed and hypokinetic types was increasing. The mixed hemodynamic type (a combination of hyper-, eu-, and particularly hypokinetic type characteristics) was considered as an incompletely developed disadaptive hypokinetic type.Conclusion.The VCO method is an effective, non-invasive way to simultaneously assess the status of multiple hemodynamic parameters in both healthy people and AH patients. A specific benefit of this method is the registration of lateral BP levels and identification of mixed (additional) hemodynamic type.
ECG DISPERSION MAPPING PARAMETERS DURING THE TREADMILL TEST IN PATIENTS WITH CORONARY HEART DISEASE
Authors: Ivanov G. G. , Agafoshina E. V. , Pecherskikh A. A. , Khalabi G. 
Published: August 2018

Aim.The aim of the study was the complex analysis of the ECG-12 and ECG dispersion mapping (DM) parameters during the physical stress test in patients with coronary heart disease (CHD).Material and methods.The main group included 143 CHD patients with Functional Class I–III angina (99 men and 44 women; mean age 50,6±4,6 years). The control group included 37 healthy individuals (mean age 44,3±4,8 years). Patients with heart failure signs and symptoms were excluded. All participants underwent the graduated physical stress test.Results.Two variants of the ECG changes were observed, with normal and abnormal reaction of ECG DM parameters. The latter group was characterised by the following: ratio of heart rate and myocardial micro-alternation index (HRmax/MMImax) 30% at the peak HR.Conclusion.Using the ECG DM method during the treadmill test is a feasible and useful approach to gain additional diagnostic information on the myocardial electro-physiological status and, therefore, to select the patients who need further examination and treatment.
DEATH CAUSES AND THEIR PREDICTION IN PATIENTS WITH THE ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME AND PRE-HOSPITAL THROMBOLYSIS
Authors: Morozov S. N. , Fedorov A. I. , Loskutova K. S. , Vertkin A. L. 
Published: August 2018

Aim.To assess effectiveness and safety of pre-hospital medical treatment in patients with acute coronary syndrome and ST segment elevation (ST-ACS) who are undergoing thrombolytic therapy (TLT); to identify TLT complications and the methods for their prediction.Material and methods.In total, the pre-hospital TLT effectiveness was assessed in 237 patients. The comparison group included 274 patients who did not undergo TLT, due to various reasons. The causes of death by Day 7–10 were analysed.Results.The leading cause of death was cardiogenic shock. In addition, in the main group, indirect myocardial rupture was a cause of death more often than in the comparison group (28% vs. 5,3%). Indirect myocardial rupture was associated with haemorrhagic complications of pre-hospital TLT. The proposed method for predicting TLT complications is based on the TIMI scale: 1–4 points suggest TLT safety; 4–5 points correspond to a higher risk of external myocardial rupture (11,6%), which implies the need to perform TLT under control of blood coagulation parameters; and ≥6 points denote the need to avoid pre-hospital TLT and use a mechanic reperfusion strategy.Conclusion.Among ST-ACS patients, mortality levels were 20,9%, which was 2,4 times higher than in the comparison group. In the main group, the morphological data obtained at autopsy demonstrated hemorrhagic myocardial transformation, which was associated with the high risk of indirect myocardial rupture (28,1%). In patients with pre-existing arterial hypertension and with the time from the ST-ACS onset of 2–3 hours, the risk of indirect myocardial rupture should be predicted, based on the TIMI scale. This will facilitate more effective assessment of the systemic TLT complication risk and selection of the optimal reperfusion strategy.
COGNITIVE DYSFUNCTION IN PATIENTS WITH ATRIAL FIBRILLATION: ASSESSING THE ROLE OF VASCULAR FACTORS
Authors: Derevnina E. S. , Akimova N. S. , Persashvili D. G. , Schwartz Yu. G. 
Published: August 2018

Aim. To study the association between the presence and type of atrial fibrillation (AF), cognitive dysfunction, and brachiocephalic artery pathology.Material and methods. In total, 54 patients with AF and 20 AF-free patients who had Functional Class I–III chronic heart failure (CHF) underwent cognitive assessment tests, echocardiography, cerebral nuclear magnetic resonance imaging, and duplex brachiocephalic ultrasound.Results. In AF patients, deteriorated parameters of memory and attention were registered. Patients with persistent AF demonstrated worse cognitive function parameters. The characteristics of short-term memory and attention, attainment of visual and motoric skills, and attention shift and span were not associated with the intima-media thickness of common carotid artery and its bifurcation.Conclusion. There is an association between the presence of AF, its type, and the severity of cognitive dysfunction, which is independent of the degree of brachiocephalic artery abnormalities.
CARDIOVASCULAR RISK FACTORS AND SELECTED PARAMETERS OF ECG DISPERSION MAPPING IN MEDICAL STUDENTS
Authors: Esina E. Yu. , Zuykova A. A. , Krasnorutskaya O. N. 
Published: August 2018

Aim.To investigate the association between the risk factors (RFs) of cardiovascular disease (CVD) and selected parameters of ECG dispersion mapping in medical students, in order to facilitate preclinical diagnostics and timely risk management.Material and methods.The study included 72 students of the Internal Disease and Paediatrics Faculties of the N. N. Burdenko Voronezh State Medical Academy, aged 21–26 years (mean age 21,9±0,1 years; 18 men and 54 women). The examination included a questionnaire survey on CVD RFs, a clinical assessment, and the measurement of hemodynamic parameters. ECG parameters, including such integral characteristics as “Myocardium”, “Rhythm”, and “Detail Code”, were assessed both at rest and during the physical stress test, using the Cardiovisor 6C device.Results.All participants were divided into two groups. In the group with multiple CVD RFs, the distribution of these factors was as follows: 40% smoked (n=6), 53% consumed 2–3 drinks of alcohol per occasion (n=8), 40% had high normal blood pressure (BP) or Stage 1 elevation of BP, based on the office measurement data (n=6). Three (20%) and 4 (27%) students were overweight (OW) and obese (O; Stage I), respectively. Low physical activity (PA) was reported by 14 students (93%), and moderate to high levels of stress by 67% (n=10) and 33% (n=5), respectively. Immediately after the physical stress test and 2 minutes later, the “Myocardium” parameter was ≥17%, being significantly different from the values observed in students without multiple RFs. Abnormal values of the integral parameters of ventricular depolarisation and left ventricular repolarisation suggest the myocardial electrical heterogeneity among students with multiple CVD RFs.Conclusion.Students with multiple CVD RFs, such as smoking, alcohol, elevated BP, OW, Stage I O, moderate to high stress levels, and low PA, also demonstrated the myocardial electrical heterogeneity during the physical stress test.
IMPROVING THE METHODOLOGY OF CONTINUOUS MEDICAL EDUCATION IN THE CONTEXT OF ARTERIAL HYPERTENSION TREATMENT
Authors: Vertkin A. L. , Skotnikov A. S. , Mychka V. B. , Prokhorova Yu. V. , Khamurzova M. A. , Uzueva E. I. 
Published: August 2018

Aim. To assess the role of the algorithm-based selection of antihypertensive therapy (AHT) and the continuous medical education in the treatment of arterial hypertension (AH).Material and methods. Based on the autopsy data, we analysed the prevalence of AH and the structure of its complications and comorbidities among 3239 patients of a multidisciplinary Moscow City hospital. We also analysed the practices of preceding ambulatory AHT and conducted the survey on the quality of continuous medical education lectures delivered to internal medicine specialists working at polyclinics.Results. Among patients who died from cardiovascular disease, a high prevalence of AH (96,1%) was combined with prevalent target organ damage (TOD), a strong association between blood pressure (BP) levels and the risk of major cardiovascular events, and a wide range of comorbidities and AH complications. There was a lack of universal AHT schemes and regimens for patients of similar age, gender, and nature and severity of comorbidities.Conclusion. Achievement of target BP levels failed to prevent major cardiovascular events which resulted in fatal outcomes. AHT was administered without adequate consideration of organo-protective and pleiotropic effects of antihypertensive medications. The development of an algorithm which considered age, gender, TOD presence, and previous major cardiovascular events in the selection of AHT had improved the doctors’ understanding of the lecture information.
VALUE OF SPECIFIC PARAMETERS AND INTEGRATIVE INDICES OF TREADMILL TEST FOR THE ASSESSMENT OF CORONARY STENOSIS SEVERITY
Authors: Martsevich S. Yu. , Tolpygina S. N. , Malysheva A. M. , Polyanskaya Yu. N. , Gofman E. A. , Lerman O. V. , Mazaev V. P. , Deev A. D. 
Published: August 2018

Aim.To assess the value of specific parameters and integrated indices (II; such as Duke Index (DI), Centre for Preventive Medicine Index (CPMI), and modified CPMI) of the treadmill test in the diagnostics of coronary stenosis severity among patients with stable coronary heart disease (CHD).Material and methods.The study included all patients (260 permanent residents of Moscow City or Moscow Region) who were admitted to the State Research Centre for Preventive Medicine with the CHD diagnosis and who underwent coronary angiography (CAG) and treadmill test in the period between January 1st 2004 and December 31st 2007.Results.There were statistically significant associations between the main treadmill test parameters and the severity of coronary artery (CA) atherosclerosis. The larger number of stenosis-affected CA was associated with a higher prevalence of chest pain and treadmill tests with positive results and ST segment depression >1 mm, as well as with a decreased total duration of treadmill test. Similarly, the increased risk, as assessed by treadmill test indices (DI, CPMI, and modified CPMI), was linked to an increased number of stenosis-affected CA. Modified CPMI demonstrated the highest diagnostic value for the assessment of coronary atherosclerosis severity.Conclusion.The treadmill test parameters which demonstrated their diagnostic value for the assessment of CHD severity included the following: positive test results, retrosternal chest pain as the reason for test discontinuation, ST segment depression >1mm, and short total duration of the test. Overall, all II demonstrated their high value in CHD diagnostics. Modified CPMI was the most effective II in the assessment of CA atherosclerosis severity.
ASSOCIATION BETWEEN BLOOD LIPID PROFILE AND BLOOD GLUCOSE LEVELS IN MEN WITH CORONARY HEART DISEASE, METABOLIC SYNDROME, AND TYPE 2 DIABETES MELLITUS
Authors: Matveeva S. A. 
Published: August 2018

Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology.
CALCIUM CHANNEL BLOCKADE AND FUNCTIONAL MICROCIRCULATION CHANGES IN HYPERTENSIVE PATIENTS WITH DIFFERENT INDIVIDUAL AND TYPOLOGICAL CHARACTERISTICS
Authors: Vasiliev A. P. , Streltsova N. N. , Shumeiko E. A. 
Published: August 2018

Aim. To identify individual and typological functional features of peripheral blood flow and assess microcirculation (MC) dynamics after a single-dose administration of nifedipine in patients with arterial hypertension (AH).Material and methods. Laser Doppler flowmetry (LDF) was used for the MC assessment in 39 patients with Stage II–III AH.Results. Marked variability in peripheral blood flow parameters was demonstrated for AH patients. Three main LDF types were identified: aperiodic (ApT), hyperemic, and hypoemic. Single-dose administration of nifedipine (20 mg) resulted in a similar antihypertensive effect across all patient groups. Positive MC dynamics was observed, which manifested in a marked increase in the number of patients with ApT (the most balanced type of peripheral blood flow regulation) and increased input of pulse blood filling into hemoperfusion.Conclusion. In AH patients, nifedipine-induced changes in peripheral blood flow were associated with an increased number of participants with ApT, as the most balanced type of MC regulation.
THERAPY COMPLIANCE IN AMBULATORY PATIENTS: PROFILE REGISTRY DATA
Authors: Lukina Yu. V. , Martsevich S. Yu. , Zagrebelnyi A. V. , Tripkosh S. G. , Aidu F. A. , Deev A. D. 
Published: August 2018

Aim.Using the data from the PROFILE Registry and the patients’ questionnaire survey, to analyse the patients’ compliance with medical recommendations on lipid-lowering therapy (LLT).Material and methods.Over the period from May 1st 2011 to December 31st 2011, 274 patients were included in the PROFILE Registry: 82 were referred to a specialised medical centre for the first time (control group, CG); 167 were regularly attending the medical centre (main group A, MGA); and 25 last visited the centre >2 years ago (main group B, MGB). 262 patients completed a questionnaire on the therapy compliance, while 12 refused to participate in the questionnaire survey.Results.According to the results of the questionnaire survey, MGA patients were better informed about the LLT goals (65%) than their CG and MGB peers (35% and 48%, respectively; p<0,0001). The percentage of patients who took statins every day was 87% in MGA vs. 41,5% in CG and 64% in MGB (p=0,002). Statin therapy effectiveness was controlled regularly in MGA: cholesterol (CH) levels were measured every 6 months in 37,5% and every 12 months in 28%. For CG, these figures were 17% and 16%, while for MGB, they were 15% and 40%, respectively (p<0,0001). One-third of CG patients, every fourth MGB patient, and only 13% of MGA patients did not control their CH levels (p<0,0001).Conclusion.The MGA patients who were regularly attending the State Research Centre for Preventive Medicine were the most LLT-compliant: they were well-informed about their disease and therapy goals, were regularly taking prescribed medications (statins), and had better treatment control and the highest LLT effectiveness.
TRIMETAZIDINE MR EFFECTS ON THE PARAMETERS OF 24-HOUR ELECTROCARDIOGRAM MONITORING AND HEART RATE VARIABILITY
Authors: Novikova M. V. , Glezer M. G. 
Published: August 2018

Aim. To assess the effects of the four-month trimetazidine MR therapy on the parameters of 24-hour electrocardiogram (ECG) monitoring and heart rate variability (HRV) in patients with stable coronary heart disease (CHD).Material and methods. This prospective, non-randomised study, with the inclusion of 66 consecutive patients who had stable CHD and stable stress test results, investigated the effects of trimetazidine MR therapy on the parameters of 24-hour ECG monitoring and HRV.Results. Trimetazidine MR did not markedly affect the 24-hour, daytime, or nighttime levels of heart rate. Trimetazidine MR therapy was not associated with any substantial changes in frequency and time-domain HRV parameters or in the incidence of cardiac arrhythmias. However, there was a significant reduction in the number of patients with ST segment depression (from 66,7% to 43,8%; p<0,001) and in the duration of ischemic episodes (from 10 (6,2;21) minutes to 7,42 (5;12,3) minutes (p=0,025)).Conclusion. Adding trimetazidine MR to the treatment of patients with stable CHD provides an additional beneficial antiischemic effect.