bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implications of coronary artery calcium testing on risk stratification for lipid-lowering therapy according to the 2016 European Society of Cardiology recommendations: The MESA study
Authors: Bittencourt Marcio S , Blankstein Ron , Blaha Michael J , Sandfort Veit , Agatston Arthur S , Budoff Matthew J , Blumenthal Roger S , Krumholz Harlan M , Nasir Khurram 
Published: July 2018

Aims The European Society of Cardiology (ESC) guideline on cardiovascular risk assessment considers coronary artery calcium a class B indication for risk assessment. We evaluated the degree to which coronary artery calcium can change the recommendation for individuals based on a change in estimated risk. Methods and results We stratified 5602 MESA participants according to the ESC recommendation as: no lipid-lowering treatment recommended ( N = 2228), consider lipid-lowering treatment if uncontrolled ( N = 1686), or lipid-lowering treatment recommended ( N = 1688). We evaluated the ability of coronary artery calcium to reclassify cardiovascular risk. Among the selected sample, 54% had coronary artery calcium of zero, 25% had coronary artery calcium of 1–100 and 21% had coronary artery calcium greater than 100. In the lipid-lowering treatment recommended group 31% had coronary artery calcium of zero, while in the lipid-lowering treatment if uncontrolled group about 50% had coronary artery calcium of zero. The cardiovascular mortality rate was 1.7%/10 years in the lipid-lowering treatment if uncontrolled, and 7.0%/10 years in the lipid-lowering treatment recommended group. The absence of coronary artery calcium was associated with 1.4%/10 years in the lipid-lowering treatment if uncontrolled group and 3.0%/10 years in the lipid-lowering treatment recommended group. Compared with coronary artery calcium of zero, any coronary artery calcium was associated with significantly higher cardiovascular mortality in the lipid-lowering treatment recommended group (9.0%/10 years), whereas only coronary artery calcium greater than 100 was significantly associated with a higher cardiovascular mortality in the lipid-lowering treatment if uncontrolled group (3.2%/10 years). Conclusion The absence of coronary artery calcium is associated with a low incidence of cardiovascular mortality or coronary heart disease events even in individuals in whom lipid-lowering therapy is recommended. A significant proportion of individuals deemed to be candidates for lipid-lowering therapy might be reclassified to a lower risk group with the use of coronary artery calcium.
RETRACTED ARTICLE: Long non-coding RNA TPT1-AS1 promotes cell growth and metastasis in cervical cancer via acting AS a sponge for miR-324-5p
Authors: Jiang Hui , Huang Guanqun , Zhao Nianzhang , Zhang Ting , Jiang Mengni , He Yueming , Zhou Xinke , Jiang Xianhan 
Published: July 2018

Abstract
Background
Increasing studies confirmed that abnormal lncRNAs expression play a critical role in cervical cancer (CC) development and progression. LncRNA TPT1-AS1, a novel lncRNA, its role and underlying mechanisms involved in CC remain largely unknown.

Methods
Colony formation, EdU and Transwell assays were used to determine colony formation, proliferation, migration and invasion in vitro. The subcutaneous tumor model and tail vein injection lung metastasis model were performed to check tumor growth and metastasis in vivo. Luciferase activity and RIP experiment were carried out to determine the interaction between miR-324-5p and TPT1-AS1.

Results
We demonstrated for the first time that TPT1-AS1 expression was up-regulated in CC tissues and cell lines. High TPT1-AS1 was significantly correlated with adverse prognostic characteristics and poor survival. TPT1-AS1 overexpression and knockdown experiments revealed that TPT1-AS1 promoted cell colony formation, proliferation, migration, invasion and EMT progression of CC cells in vitro and in vivo. The underlying mechanism indicated that TPT1-AS1 functioned as an endogenous sponge for miR-324-5p in CC cells. Gain- and loss- experiment confirmed that miR-324-5p inhibited cell colony formation, proliferation, migration, invasion and EMT progression of CC cells, and mediated the biological effects of TPT1-AS1. Further investigations confirmed that SP1 was a direct target of miR-324-5p and mediated the effects of TPT1-AS1 and miR-324-5p in CC.

Conclusions
We demonstrated for the first time that TPT1-AS1 as an oncogenic lncRNA in CC progression and as a potential target for CC cure.
Skin autofluorescence assessment of cardiovascular risk in people with severe mental illness
Authors: Emmerink Daniëlle , Bakker Sybiel , Van Bemmel Thomas , Noorthoorn Eric O. , Naarding Paul 
Published: July 2018

BackgroundPeople with severe mental illness (SMI) show significantly shorter life expectancy, mostly due to more prevalent cardiovascular disease. Although age is a prominent contributor to contemporary risk assessment and SMI usually affects younger people, these assessments still do not reveal the actual risk. By assessing advanced glycation end products (AGEs), cardiovascular risk can be assessed independent of age.AimsTo establish whether detection of AGEs with the AGE-reader will give a more accurate cardiovascular risk assessment in people with SMI.MethodWe compared assessment with the AGE-reader with that of the Systematic Coronary Risk Evaluation (SCORE) table in a group of 120 patients with SMI.ResultsThe AGE-reader showed an increased cardiovascular risk more often than the SCORE table, especially in the youngest group.ConclusionsBecause of its ease of use and substantiation by studies done on other chronic diseases, we advocate use of the AGE-reader in daily care for patients with SMI to detect cardiovascular risk as early as possible. However, the findings of the current study should be evaluated with caution and should be seen as preliminary findings that require confirmation by a prospective longitudinal cohort study with a substantial follow-up observation period.Declaration of interestNone.
Ibrutinib Monotherapy in Symptomatic, Treatment-Naïve Patients With Waldenström Macroglobulinemia
Authors: Treon Steven P. , Gustine Joshua , Meid Kirsten , Yang Guang , Xu Lian , Liu Xia , Demos Maria , Kofides Amanda , Tsakmaklis Nicholas , Chen Jiaji G. , Munshi Manit , Chan Gloria , Dubeau Toni , Raje Noopur , Yee Andrew , O’Donnell Elizabeth , Hunter Zachary R. , Castillo Jorge J. 
Published: July 2018

Purpose Ibrutinib is active in previously treated Waldenström macroglobulinemia (WM). MYD88 mutations ( MYD88MUT) and CXCR4 mutations ( CXCR4MUT) affect ibrutinib response. We report on a prospective study of ibrutinib monotherapy in symptomatic, untreated patients with WM, and the effect of CXCR4MUT status on outcome. Patients and Methods Symptomatic, treatment-naïve patients with WM were eligible. Ibrutinib (420 mg) was administered daily until progression or unacceptable toxicity. All tumors were genotyped for MYD88MUT and CXCR4MUT. Results A total of 30 patients with WM received ibrutinib. All carried MYD88MUT, and 14 (47%) carried a CXCR4MUT. After ibrutinib treatment, median serum IgM levels declined from 4,370 to 1,513 mg/dL, bone marrow involvement declined from 65% to 20%, and hemoglobin level rose from 10.3 to 13.9 g/dL ( P < .001 for all comparisons). Overall (minor or more than minor) and major (partial or greater than partial) responses for all patients were 100% and 83%, respectively. Rates of major (94% v 71%) and very good partial (31 v 7%) responses were higher and time to major responses more rapid (1.8 v 7.3 months; P = 0.01) in patients with wild-type CXCR4 versus those with CXCR4MUT, respectively. With a median follow-up of 14.6 months, disease in two patients (both with CXCR4MUT) progressed. The 18-month, estimated progression-free survival is 92% (95% CI, 73% to 98%). All patients are alive. Grade 2/3 treatment-related toxicities in > 5% of patients included arthralgia (7%), bruising (7%), neutropenia (7%), upper respiratory tract infection (7%), urinary tract infection (7%), atrial fibrillation (10%), and hypertension (13%). There were no grade 4 or unexpected toxicities. Conclusion Ibrutinib is highly active, produces durable responses, and is safe as primary therapy in patients with symptomatic WM. CXCR4MUT status affects responses to ibrutinib.
Pharmacological Characters of Oliceridine, a μ-Opioid Receptor G-Protein–Biased Ligand in Mice
Authors: Liang De-Yong , Li Wen-Wu , Nwaneshiudu Chinwe , Irvine Karen-Amanda , Clark J. David 
Published: July 2018

BACKGROUND:
A major advancement in the field of analgesic pharmacology has been the development of G-protein–biased opioid agonists that display less respiratory depression than conventional drugs. It is uncertain, however, whether these new drugs cause less tolerance, hyperalgesia, and other maladaptations when administered repeatedly.

METHODS:
The archetypical µ-opioid receptor agonist morphine and, separately, the G-protein–biased µ-opioid receptor agonist oliceridine were administered to mice. These drugs were used in models of acute analgesia, analgesic tolerance, opioid-induced hyperalgesia, reward, and physical dependence. In addition, morphine and oliceridine were administered for 7 days after tibia fracture and pinning; mechanical allodynia and gait were followed for 3 weeks. Finally, the expression of toll-like receptor-4 and nacht domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NALP3) and interleukin-1β mRNA were quantified in spinal tissue to measure surgical and drug effects on glia-related gene expression.

RESULTS:
We observed using the tail flick assay that oliceridine was a 4-fold more potent analgesic than morphine, but that oliceridine treatment caused less tolerance and opioid-induced hyperalgesia than morphine after 4 days of ascending-dose administration. Using similar analgesic doses, morphine caused reward behavior in the conditioned place preference assay while oliceridine did not. Physical dependence was, however, similar for the 2 drugs. Likewise, morphine appeared to more significantly impair the recovery of nociceptive sensitization and gait after tibial fracture and pinning than oliceridine. Furthermore, spinal cord toll-like receptor-4 levels 3 weeks after fracture were higher in fracture mice given morphine than those given oliceridine.

CONCLUSIONS:
Aside from reduced respiratory depression, G-protein–biased agonists such as oliceridine may reduce opioid maladaptations and enhance the quality of surgical recovery.
Influence of Nasal Tip Lifting on the Incidence of the Tracheal Tube Pathway Passing Through the Nostril During Nasotracheal Intubation: A Randomized Controlled Trial
Authors: Kim Hyerim , Lee Jung-Man , Lee Jiwon , Hwang Jin-Young , Chang Jee-Eun , No Hyun-Joung , Won Dongwook , Choi Seungeun , Min Seong-Won 
Published: July 2018

BACKGROUND:
For safe nasotracheal intubation without middle turbinate injury, the tracheal tube should pass through the lower pathway, which is beneath the inferior turbinate and immediately above the nasal floor of the nostril. The purpose of this study was to assess the influence of nasal tip lifting on the incidence of passing preformed nasal Ring-Adair-Elwyn (RAE) tubes through the lower pathway during nasotracheal intubation.

METHODS:
Patients were randomly assigned to a “nasal tip lifting group” or a “neutral group.” For patients in the nasal tip lifting group, an investigator pulled the nasal tip in a cephalad direction when inserting a preformed nasal RAE tube into the nostril after induction of anesthesia. For patients in the neutral group, a tube was inserted with the nasal tip in a neutral position. The pathway by which the tube passed in each patient was identified using a fiberscope. The incidence of the tube passing through the lower pathway was compared between the 2 groups. The incidence of epistaxis was also evaluated.

RESULTS:
Eighty-six patients were enrolled and completed the study protocol. The incidence of the tracheal tube passing through the lower pathway was significantly higher in the nasal tip lifting group (79.1%) than in the neutral group (51.2%) (relative risk, 1.55; 95% confidence interval, 1.11–2.15; P = .007). Although the incidence of epistaxis was not different between the groups (18.6% vs 32.6%; P = .138), it was lower when the tracheal tube passed nasal cavity through the lower pathway (14.3%) than the upper pathway (46.7%), regardless of the randomized group with adjustment for potentially confounding variables (odds ratio, 0.19; 95% confidence interval, 0.07–0.54; P = .002).

CONCLUSIONS:
The nasal tip lifting maneuver helped to guide preformed nasal RAE tubes into the lower pathway during nasotracheal intubation.
Communists, Commissars, and Consumers: The Politics of Food on the Chilean Road to Socialism
Authors: Frens-String Joshua 
Published: July 2018

Abstract
This article examines the politics of food during Chile's Popular Unity (UP) revolution (1970–73). Organized around the rise and fall of the Juntas de Abastecimiento y Precios (Price and Supply Committees, JAPs), a state-backed network of collectively managed stores and ad hoc food distribution sites, the article explores how the UP revolution expanded long-standing practices of community-led price monitoring and food distribution to make the promise of economic democracy more concrete for urban, working-class consumers. As the JAPs' power grew, however, such efforts became a political lightning rod, unifying Chile's domestic opposition around the claim that the state's presence in the food economy—rather than its absence—created scarcity and needlessly politicized domestic life. Ultimately, the article contends that the consumer marketplace was a key arena for competing conceptualizations of democracy and the state in early 1970s Chile, anticipating the centrality of consumption to the neoliberal counterrevolution that the country experienced in the post-UP era.
Brains
Authors: Gailus Andreas 
Published: July 2018

AbstractThe literary writings of the young Gottfried Benn are replete with images of anatomical dismemberment and biological decay while pushing the limits of linguistic expression. The article suggests that this confluence of naturalism and avant-garde experimentation is the result of Benn’s critical engagement with the modern life sciences, and in particular with the discourses of medicine and psychology. The article focuses on Benn’s so-called Rönne novellas, written between 1914 and 1916, arguing that they record and enact the disintegration of body and subjectivity through a medical discourse that gives way to an experimental prose freed from the constraints of reference and meaning.
“The Great Imitator”
Authors: Magnusen Kaia L. 
Published: July 2018

Abstract
During the Weimar Republic the categories of “good,” traditional women and “deviant,” modern women became imprecise as widows’ veils and garb were often adopted by prostitutes to deter arrest. Widows were linked with death and Germany’s postwar shame and were often unfairly associated with prostitutes. Otto Dix, a Neue Sachlichkeit artist, was aware of the postwar ambiguity between “respectable” and “fallen” women. In a watercolor of a veiled widow, Dix engaged the elision of prostitutes and widows by visually implying she has syphilis, a disease that caused widespread anxiety and was inextricably linked with prostitutes. Just as syphilis was referred to as “the Great Imitator” because of the difficulty of diagnosing it, so prostitutes masqueraded as “morally upright” widows. This ambiguity between moral and immoral women caused concern over Germany’s perceived moral decline and fascinated Dix, who was intrigued by the dangerous nexus of sexuality, disease, and death.
“Das Steffinische Sternbild”
Authors: Hollander Katherine 
Published: July 2018

AbstractBetween 1931 and 1941 Bertolt Brecht and Margarete Steffin were lovers, friends, and intellectual collaborators. Yet scholars have struggled to understand the mechanics of their collaborative style, and presentist and liberal notions of authorship and accreditation have concentrated scholarly discussions away from Brecht and Steffin’s more urgent priorities as exiles, socialists, and antifascists. This article uses Brecht’s poems of mourning for Steffin, collectively known as “Nach dem Tod Meiner Mitarbeiterin M.S.,” along with letters, journal entries, and relevant contemporary scientific and medical understandings, to place the poems and the relationship more firmly within their specific historical environment. In the context of Brecht and Steffin’s evolving socialism, as well as the increasingly limited resources available to them once in exile, the intimate and effective literary cooperation they achieved was of primary importance. This fresh reading of the poems presents historicized insights into Brecht’s use of imagery and suggests a way forward for scholarship of collaborative literary relationships.
Where the Earth Folded
Authors: Klenner Jens 
Published: July 2018

Abstract“Gespräch im Gebirg” (“Conversation in the Mountains”), Paul Celan’s only prose piece published during his lifetime, is often described as failed conversation, paradoxical or undecided in language and structure. Points of reference are frequently a dialogic structure of “I” and “thou” in light of Émile Benveniste, Emmanuel Levinas, Franz Rosenzweig, and Martin Heidegger, or Celan’s missed encounter with Theodor W. Adorno. It has, however, largely gone unremarked that Celan undertook an intensive reading of Gottfried Wilhelm Leibniz’s Monadology in August 1959, at the same time that his manuscripts show he was working on “Conversation.” In Leibniz Celan discovers the fold as the underlying principle of the monad, and, as the article shows, the figure of the fold pervades the imagery, the language, and the structure of “Conversation.” Celan uses the fold as a radically new literary form, as a nonindexical linguistic device to resist the harm and violence brought about through a language used for classification and delineation, and as a poetic figure to write an impossible conversation into existence.
Cell tracking in vitro reveals that the extracellular matrix glycoprotein Tenascin-C modulates cell cycle length and differentiation in neural stem/progenitor cells of the developing mouse spinal cord
Authors: May Marcus , Denecke Bernd , Schroeder Timm , Götz Magdalena , Faissner Andreas 
Published: July 2018

ABSTRACT
Generation of astrocytes during the development of the mammalian spinal cord is poorly understood. Previously, we have shown that the glycoprotein of the extracellular matrix (ECM) tenascin-C (Tnc) modulates the expression territories of the patterning genes Nkx6.1 and Nkx2.2 in the developing ventral spinal cord, tunes the responsiveness of neural stem/progenitor cells towards the cytokines FGF2 and EGF and thereby promotes astrocyte maturation. In order to obtain further mechanistic insight into these processes, we have compared embryonic day-15 spinal cord neural progenitor cells (NPCs) from wild-type and Tnc knockout mice using continuous single-cell live imaging and cell lineage analysis in vitro. Tnc knockout cells displayed a significantly reduced rate of cell division both in response to FGF2 and EGF. When individual clones of dividing cells were investigated with regard to their cell lineage trees using the tTt tracking software, it appeared that the cell cycle length in response to growth factors was reduced in the knockout. Furthermore, when Tnc knockout NPCs were induced to differentiate by the removal of FGF2 and EGF glial differentiation was enhanced. We conclude that the constituent of the stem cell niche Tnc contributes to preserve stemness of NPCs.
A mesodermal fate map for adipose tissue
Authors: Sebo Zachary L. , Jeffery Elise , Holtrup Brandon , Rodeheffer Matthew S. 
Published: July 2018

ABSTRACT
The embryonic origin of distinct fat depots and the role for ontogeny in specifying the functional differences among adipocyte lineages between and within depots is unclear. Using a Cre/Lox-based strategy to track the fate of major mesodermal subcompartments in mice we present evidence that &lt;50% of interscapular brown adipocytes are derived from progenitors of the central dermomyotome. Furthermore, we demonstrate that depot-specific adipocyte lineages spatially diverge as early as gastrulation, and that perigonadal adipocytes arise from separate mesodermal subcompartments in males and females. Last, we show adipocyte precursors (APs) of distinct lineages within the same depot exhibit indistinguishable responses to a high fat diet, indicating that ontogenetic differences between APs do not necessarily correspond to functional differences in this context. Altogether, these findings shed light on adipose tissue patterning and suggest that the behavior of adipocyte lineage cells is not strictly determined by developmental history.
Sustentabilidade solidária ou solidariedade sustentável? Em busca de um conceito uníssono
Authors: Garcia Denise Schmitt Siqueira , Garcia Heloise Siqueira 
Published: July 2018

Solidarity sustainable or sustainable solidarity? In search of a unison concept O presente artigo tem como objetivo geral estabelecer uma integração conceitual da sustentabilidade e da solidariedade, desenrolando-se o estudo com o alcance dos seguintes objetivos específicos: analisar os principais aspectos da sustentabilidade, enfocando primordialmente sua dimensão social; estudar a solidariedade principalmente em seus aspectos históricos e conceituais, para, ao final, poder compreender a íntima correlação entre ambas as categorias. Com relação à metodologia adotada, ressalta-se que a opção se deu pelo método indutivo, tendo sido acionadas as técnicas do referente, da categoria, dos conceitos operacionais, da pesquisa bibliográfica e do fichamento. The objective of this article is to establish a conceptual integration of Sustainability and Solidarity, and the study will be carried out with the following specific objectives: to analyze the main aspects of Sustainability, focusing primarily on its social dimension; to study Solidarity mainly in its historical and conceptual aspects; and at the end, to understand the close correlation between the two categories. Regarding the adopted methodology, it was pointed out that the option was based on the inductive method, and the techniques of the referent, the category, the operational concepts, the bibliographic research and the file.