bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implication of inflammatory cytokines in the aqueous humour for management of macular diseases
Authors: Yi Quan‐Yong , Wang Yan‐Yan , Chen Li‐Shuang , Li Wen‐Die , Shen Yu , Jin Yuanhui , Yang Jie , Wang Yuwen , Yuan Jianshu , Cheng Lingyun 
Published: September 2019

AbstractPurposeTo characterize profile of cytokines in aqueous humour of common macular diseases during intravitreal anti‐VEGF therapy.MethodsAqueous humour from eyes with central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO), diabetic macular oedema (DME), neovascular age‐related macular degeneration (nAMD) or pathologic myopia associated choroidal neovascularization (pmCNV) was sampled prior to 1st (n = 144) and 2nd (n = 48) intravitreal anti‐VEGF therapy. Cytokines including vascular endothelium growth factor (VEGF), intercellular adhesion molecule 1 (ICAM‐1) and interleukin 6 (IL‐6) were quantitated and analysed along with retinal thickness data by optical coherence tomography (OCT) across two intravitreal injections and five macular disease types.ResultsICAM‐1, IL‐6 and VEGF are positively associated in the aqueous humour of naive eyes (r = 0.39–0.77, p = 0.018 to <0.0001). ICAM‐1, VEGF and IL‐6 were significantly higher in CRVO and DME while lowest in pmCNV (p < 0.0001). Reduction of central retinal thickness (CRT) as a favourable response to anti‐VEGF therapy was in the order of CRVO, BRVO, DME and nAMD/pmCNV (p < 0.0001). The strongest predictor for favourable CRT reduction was baseline CRT (p < 0.0001) followed by baseline ICAM‐1 (p = 0.04). After the 1st intravitreal anti‐VEGF therapy, VEGF in aqueous humour lowered significantly but ICAM‐1 and IL‐6 levels remained unchanged. ICAM‐1 was not predictive for CRT reduction following 2nd anti‐VEGF therapy.ConclusionRate of cytokine production is disease‐dependent and higher in CRVO and DME. Anatomical response to intravitreal anti‐VEGF therapy is disease‐specific and best in RVO patients. A combination therapy using both anti‐VEGF and anti‐inflammatory therapeutics may be superior to single anti‐VEGF therapy, at least for RVO and DME.
Editorial: anti‐TNF therapy—a double‐edged sword?
Authors: Schreiner Philipp , Biedermann Luc 
Published: September 2019

LINKED CONTENT
This article is linked to Korzenik et al papers. To view these articles, visit https://doi.org/10.1111/apt.15370 and https://doi.org/10.1111/apt.15459.
Editorial: understanding differences in patient response to ondansetron in irritable bowel syndrome with diarrhoea—are we any closer?
Authors: Black Christopher J. , Ford Alexander C. , Houghton Lesley A. 
Published: September 2019

LINKED CONTENT
This article is linked to Gunn et al papers. To view these articles, visit https://doi.org/10.1111/apt.15420 and https://doi.org/10.1111/apt.15465.
Editorial: anti‐TNF therapy—a double‐edged sword? Authors' reply
Authors: Korzenik Joshua , Larsen Michael Due , Nielsen Jan , Kjeldsen Jens , Nørgård Bente Mertz 
Published: September 2019

LINKED CONTENT
This article is linked to Korzenik et al and Schreiner and Biedermann papers. To view these articles, visit https://doi.org/10.1111/apt.15370 and https://doi.org/10.1111/apt.15401.
Editorial: when, who and how—the ever‐evolving management of pancreatic cystic lesions. Authors’ reply
Authors: Overbeek Kasper A. , Cahen Djuna L. , Bruno Marco J. 
Published: September 2019

LINKED CONTENT
This article is linked to Overbeek et al and Yang and Forsmark papers. To view these articles, visit https://doi.org/10.1111/apt.15440 and https://doi.org/10.1111/apt.15471.
Trends of mobile learning: A review of the top 100 highly cited papers
Authors: Lai Chiu‐Lin 
Published: September 2019

AbstractHighly cited papers can be representative of the latest changes in specific research issues, as they reflect the important issues or research trends that researchers have paid attention to recently. Through reading highly cited papers, researchers can identify some important issues for consideration in their own research, which can then catch other researchers’ eyes easily and efficiently. In order to explore the feature of the latest changes in mobile learning, in this study, a review of the top 100 highly cited mobile learning papers was conducted. According to the review, four advantages were identified from the highly cited mobile learning studies: proposing new learning strategies, applying mobile learning to seldom‐considered subjects, applying mobile learning to seldom‐investigated domains and investigating seldom‐discussed issues. It was found that the studies focused more on comparing different mobile learning modes for finding more effective mobile learning approaches rather than comparing the impacts of mobile learning with traditional instruction. Moreover, the studies focused more on learners’ higher order thinking performance and learning behaviors. Some suggestions, differing from those presented by previous mobile learning reviews, are provided as reference for researchers to conduct related research.
Practitioner NotesWhat is already known about this topic

Mobile learning has been regarded as a tool for improving learners’ learning and bridging students’ learning in class and in the field.
Research trends can be highlighted and provide a more accurate view of the publication patterns.
Highly cited papers can be used to identify the advance of the research foci.
What this paper adds

Most highly cited studies mainly focused on comparing the different mobile learning modes to find more effective approaches for conducting mobile learning activities.
The mobile learning places have changed from classrooms to real‐world contexts; in addition, the number of across‐context studies is increasing.
The highly cited papers started to focus more on learners’ higher‐order thinking performance and learning behaviors.
Implications for practice and/or policy

Researchers can consider proposing new learning strategies, applying mobile learning to seldom‐considered subjects, applying mobile learning to seldom‐investigated domains, and investigating seldom‐discussed issues.
Adopting mixed methods is becoming the mainstream of mobile learning studies.
Several seldom‐discussed issues, such as higher order thinking, collaboration/communication skills, and learning behaviors are potential mobile learning research topics.
Classical Ehlers‐Danlos syndrome with a propensity to arterial events: A new report on a French family with a COL1A1 p.(Arg312Cys) variant
Authors: Adham Salma , Dupuis‐Girod Sophie , Charpentier Etienne , Mazzella Jean‐Michaël , Jeunemaitre Xavier , Legrand Anne 
Published: September 2019

AbstractEhlers‐Danlos syndromes (EDS) are a clinically and genetically heterogeneous group of connective tissue disorders. Overlapping features including arterial aneurysms/dissections in both classical and vascular EDS are a major challenge in the clinical diagnosis of these subtypes. The COL1A1 p.(Arg312Cys) variant leads to a phenotype of classical EDS with a propensity to arterial complications. Our report describes a two‐generation family with one individual presenting with a dissection of the right external iliac artery. The primary suspicion of vascular EDS with the unsatisfactory identification of a COL3A1 benign variant was secondarily readjusted with the identification of COL1A1 p.(Arg312Cys) variant. This raises the question of the association of COL1A1 p.(Arg312Cys) with arterial complications and the need for a gene panel including not only the usual genes tested in search of classical or vascular EDS but also COL1A1.
Racial disparities in patient selection for liver transplantation: An ongoing challenge
Authors: Jesse Michelle T. , Abouljoud Marwan , Goldstein Eric D. , Rebhan Nicholas , Ho Chuan‐Xing , Macaulay Taylor , Bebanic Mubera , Shkokani Lina , Moonka Dilip , Yoshida Atsushi 
Published: September 2019

AbstractAmple evidence suggests continued racial disparities once listed for liver transplantation, though few studies examine disparities in the selection process for listing. The objective of this study, via retrospective chart review, was to determine whether listing for liver transplantation was influenced by socioeconomic status and race/ethnicity. We identified 1968 patients with end‐stage liver disease who underwent evaluation at a large, Midwestern center from January 1, 2004 through December 31, 2012 (72.9% white, 19.6% black, and 7.5% other). Over half (54.6%) of evaluated patients were listed; the three most common reasons for not listing were medical contraindications (11.9%), patient expired during evaluation (7.0%), and psychosocial contraindications (5.9%). In multivariable logistic regressions (listed vs not listed), across the three racial categories, the odds of being listed were lower for alcohol‐induced hepatitis (±hepatitis C), unmarried, more than one insurance, inadequate insurance, and lower annual household income quartile. Similar factors predicted time to transplant listing, including being identified as black race. Black race, even when adjusting for the above mentioned medical and socioeconomic factors, was associated with 26% lower odds of being listed and a longer time to listing decision compared to all other patients.
The University Classroom, Harassment, and Challenging Provocation
Authors: Harless Jessica 
Published: September 2019

AbstractThe university exhibits particular complexities when it comes to understanding and addressing the gendered harassment that takes place within it. Notions about the nature of higher education and the pedagogical commitments therein can make it difficult to determine the hostility of an environment (a factor crucial to diagnosing harassment). In this article, Jessica Harless taps into some of the vast literature on classroom dialogue, pedagogies of discomfort, and provocative teaching in order to outline difficulties that can arise when attempting to distinguish a challenging learning environment from a harassing one. Harless suggests that rather than relying on descriptive, objective definitions of harassing hostility, we look at subjective factors and the consequences of harassment to try to clarify what it is. Participation, which is expressly protected by Title IX, is one concept available to help gauge the nature of the learning environment. However, the type of participation to be ensured is full participation — unthwarted participant flourishing that goes beyond mere presence or access. This article ultimately focuses on the role and effects of teachers within the classroom environment and highlights a kind of pedagogical commitment that sustains both provocation of challenge and reduction of hostility and harassment.
Stop Being So Melodramatic! Or, the Problem with Sexual Harassment Policies
Authors: Howlett Caitlin 
Published: September 2019

AbstractIn this article, Caitlin Howlett offers a critical framework for understanding the limits of prohibitive and individually oriented sexual harassment policies in academia through a discussion of melodrama. Howlett draws on the work of Linda Williams, Emma Goldman, and Carole Vance in arguing that such sexual harassment policies participate in melodrama and thus fail to address the structural or institutional conditions that allow for sexual harassment. She then turns to the work of Sara Ahmed to examine what is at stake in this failure, before concluding that this understanding of sexual harassment policies points to their insufficiency and inadequacy within the academy.
Reaction Is Not Enough: Decreasing Gendered Harassment in Academic Contexts in Chile, Hong Kong, and the United States
Authors: Jackson Liz , Muñoz‐García Ana Luisa 
Published: September 2019

AbstractIn diverse academic spaces around the world, sexual and gendered harassment is increasingly recognized as a problem. High‐profile cases continue to emerge that underscore how gendered harassment is normalized in elite research contexts. In this article, Liz Jackson and Ana Luisa Muñoz‐García analyze three recent policy cases for decreasing sexual and gendered harassment. These cases involve three levels of analysis and three cultural contexts. The first is that of the higher education community in Chile; the second is the University of Hong Kong; and the third is the Philosophy of Education Society, an international academic society based in North America. In each case we analyze how sexual and gendered harassment has been (1) conceptualized, (2) responded to, and (3) contextualized. Through their analysis of these cases, Jackson and Muñoz‐García invite readers to reflect on practical and philosophical recommendations for moving forward antiharassment policies and programs, seen broadly.
The Right to Be Frivolous? An Intersectional Analysis of Gendered Harassment
Authors: Li Huey‐li 
Published: September 2019

AbstractIn this essay, Huey‐li Li first undertakes a reexamination of the theoretical and practical merits of applying intersectionality to analyze how gender infiltrates and becomes entangled with other registers of nonsexual harassment. She further presents three vignettes of ambiguous nonsexual harassment in order to inquire into how the intersections among gender, disciplinary identity, disability, linguistic identity, and race/ethnicity shape divergent, unsettled, and ambiguous perceptions of harassment. Instead of seeking legal remedies for non‐monolithic gendered harassment, Li argues for systematic educational remedies that attend to the complex and complicated intersections between gender and the other registers of harassment in order to transform discriminatory and oppressive cultural practices.
Working days in a London construction team in the eighteenth century: evidence from St Paul's Cathedral
Authors: Stephenson Judy Z. 
Published: September 2019

AbstractThis article provides new information and data on the work and pay of skilled and semi‐skilled men on a large London construction project in the early 1700s. It offers firm‐level evidence on the employment relation in the construction industry at the time and sheds some light on the number of days worked per year and per week, showing that employment was more irregular and seasonal than current estimates of income infer. The patterns are considered in the context of new debates about industriousness and economic growth.
Inclusion of discards in stock assessment models
Authors: Cook Robin M. 
Published: September 2019

AbstractA large portion of the catch in many stocks may comprise discards which need to be accounted for in assessments in order to avoid bias in estimates of fishing mortality, stock biomass and reference points. In age‐structured assessment models, discards are sometimes treated as a separate fleet or are added to the landings before fitting so that information about discard behaviour and sampling error is lost. In this paper, an assessment model is developed to describe the discard process with size as a covariate while retaining age‐structured population dynamics. Discard size selection, high grading and bulk dumping of fish at sea are modelled so that the temporal dynamics of the process can be quantified within the assessment. The model is used to show that discarding practices have changed over time in a range of Northeast Atlantic demersal fish. In some stocks, there is a substantial increase in high grading and evidence for bulk discarding which can be related to regulatory measures. The model offers a means of identifying transient effects in the discard process that should be removed from both short‐term forecasts and equilibrium reference point calculations.
Polysaccharide oxidation by lytic polysaccharide monooxygenase is enhanced by engineered cellobiose dehydrogenase
Authors: Kracher Daniel , Forsberg Zarah , Bissaro Bastien , Gangl Sonja , Preims Marita , Sygmund Christoph , Eijsink Vincent G. H. , Ludwig Roland 
Published: September 2019

The catalytic function of lytic polysaccharide monooxygenases (LPMOs) to cleave and decrystallize recalcitrant polysaccharides put these enzymes in the spotlight of fundamental and applied research. Here we demonstrate that the demand of LPMO for an electron donor and an oxygen species as cosubstrate can be fulfilled by a single auxiliary enzyme: an engineered fungal cellobiose dehydrogenase (CDH) with increased oxidase activity. The engineered CDH was about 30 times more efficient in driving the LPMO reaction due to its 27 time increased production of H2O2 acting as a cosubstrate for LPMO. Transient kinetic measurements confirmed that intra‐ and intermolecular electron transfer rates of the engineered CDH were similar to the wild‐type CDH, meaning that the mutations had not compromised CDH’s role as an electron donor. These results support the notion of H2O2‐driven LPMO activity and shed new light on the role of CDH in activating LPMOs. Importantly, the results also demonstrate that the use of the engineered CDH results in fast and steady LPMO reactions with CDH‐generated H2O2 as a cosubstrate, which may provide new opportunities to employ LPMOs in biomass hydrolysis to generate fuels and chemicals.
Characterising the biophysical, economic and social impacts of soil carbon sequestration as a greenhouse gas removal technology
Authors: Sykes Alasdair J. , Macleod Michael , Eory Vera , Rees Robert M. , Payen Florian , Myrgiotis Vasilis , Williams Mathew , Sohi Saran , Hillier Jon , Moran Dominic , Manning David A. C. , Goglio Pietro , Seghetta Michele , Williams Adrian , Harris Jim , Dondini Marta , Walton Jack , House Joanna , Smith Pete 
Published: September 2019

AbstractTo limit warming to well below 2°C, most scenario projections rely on greenhouse gas removal technologies (GGRTs); one such GGRT uses soil carbon sequestration (SCS) in agricultural land. In addition to their role in mitigating climate change, SCS practices play a role in delivering agroecosystem resilience, climate change adaptability and food security. Environmental heterogeneity and differences in agricultural practices challenge the practical implementation of SCS, and our analysis addresses the associated knowledge gap. Previous assessments have focused on global potentials, but there is a need among policymakers to operationalise SCS. Here, we assess a range of practices already proposed to deliver SCS, and distil these into a subset of specific measures. We provide a multidisciplinary summary of the barriers and potential incentives towards practical implementation of these measures. First, we identify specific practices with potential for both a positive impact on SCS at farm level and an uptake rate compatible with global impact. These focus on: (a) optimising crop primary productivity (e.g. nutrient optimisation, pH management, irrigation); (b) reducing soil disturbance and managing soil physical properties (e.g. improved rotations, minimum till); (c) minimising deliberate removal of C or lateral transport via erosion processes (e.g. support measures, bare fallow reduction); (d) addition of C produced outside the system (e.g. organic manure amendments, biochar addition); (e) provision of additional C inputs within the cropping system (e.g. agroforestry, cover cropping). We then consider economic and non‐cost barriers and incentives for land managers implementing these measures, along with the potential externalised impacts of implementation. This offers a framework and reference point for holistic assessment of the impacts of SCS. Finally, we summarise and discuss the ability of extant scientific approaches to quantify the technical potential and externalities of SCS measures, and the barriers and incentives to their implementation in global agricultural systems.
Canopy height explains species richness in the largest clade of Neotropical lianas
Authors: Meyer Leila , Diniz‐Filho José Alexandre F. , Lohmann Lúcia G. , Hortal Joaquín , Barreto Elisa , Rangel Thiago , Kissling W. Daniel 
Published: September 2019

AbstractAimTall and structurally complex forests can provide ample habitat and niche space for climbing plants, supporting high liana species richness. We test to what extent canopy height (as a proxy of 3‐D habitat structure), climate and soil interact to determine species richness in the largest clade of Neotropical lianas. We expect that the effect of canopy height on species richness is higher for lianas from closed tropical rain forests compared to riparian and savanna habitats.LocationNeotropics.Time periodPresent.Major taxa studiedTribe Bignonieae (Bignoniaceae).MethodsWe used structural equation models to evaluate direct and indirect effects of canopy height, climate (temperature, precipitation and precipitation seasonality), and soil (cation exchange capacity and soil types) on overall Bignonieae species richness (339 liana species), as well as on species richness of lianas from forest, riparian and savanna habitats, respectively. We further performed multiple regression models with Moran's eigenvector maps to account for spatial autocorrelation.ResultsCanopy height was a key driver of liana species richness, in addition to climate and soil. Species richness of forest lianas showed a strong positive relationship with canopy height whereas the relationship was less pronounced for riparian species. Richness of savanna species decreased with increasing canopy height. Climate also explained a substantial proportion of variation in liana species richness whereas soil variables showed little explanatory power.Main conclusionsThe relationship between canopy height and liana species richness differs among habitats. While forest and riparian lianas benefit from tall and complex habitats that provide physical support to reach the canopy to escape low light availability in the understorey, high light availability in open habitats and an increased risk of embolism of conductive vessels for lianas with long stems living in areas with high seasonality might explain the inverse relationship between species richness and canopy height in savannas.
Prevalence and management of drug–drug interactions with antiretroviral treatment in 2069 people living with HIV in rural Tanzania: a prospective cohort study
Authors: Schlaeppi C , Vanobberghen F , Sikalengo G , Glass TR , Ndege RC , Foe G , Kuemmerle A , Paris DH , Battegay M , Marzolini C , Weisser M ,   the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) study group
Published: September 2019

ObjectivesWidespread access to antiretroviral therapy (ART) has substantially increased life expectancy in sub‐Saharan African countries. As a result, the rates of comorbidities and use of co‐medications among people living with HIV are increasing, necessitating a sound understanding of drug–drug interactions (DDIs). We aimed to assess the prevalence and management of DDIs with ART in a rural Tanzanian setting.MethodsWe included consenting HIV‐positive adults initiating ART in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) between January 2013 and December 2016. DDIs were classified using www.hiv-druginteractions.org as red (contra‐indicated), amber (potential clinical relevance requiring dosage adjustment/monitoring), yellow (weak clinical significance unlikely to require further management) or green (no interaction). We assessed management of amber DDIs by evaluating monitoring of laboratory or clinical parameters, or changes in drug dosages.ResultsOf 2069 participants, 1945 (94%) were prescribed at least one co‐medication during a median follow‐up of 1.8 years. Of these, 645 (33%) had at least one potentially clinically relevant DDI, with the highest grade being red in nine (< 1%) and amber in 636 (33%) participants. Of the 23 283 prescriptions, 19 (< 1%) and 1745 (7%) were classified as red and amber DDIs, respectively. Overall, 351 (2%) prescriptions were red DDIs or not appropriately managed amber DDIs.ConclusionsCo‐medication use was common in this rural sub‐Saharan cohort. A third of participants had DDIs requiring further management. Of the 9% of participants with not appropriately managed DDIs, most were with cardiovascular and analgesic drugs. This highlights the importance of physicians’ awareness of DDIs for their recognition and management.