bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence of eustachian tube dysfunction symptoms in temporomandibular joint disorder patients
Authors: Newman Alan C. , Omrani Katayoun , Higgins Thomas S. , Ting Jonathan Y. , Walgama Evan S. , Wu Arthur W. 
Published: July 2019

Objectives/HypothesisEar fullness and pressure is a common complaint seen in otolaryngology clinics and frequently is attributed to eustachian tube dysfunction (ETD). In addition to traditional tympanometry and physical examination, the seven‐item Eustachian Tube Dysfunction Questionnaire (ETDQ‐7) has recently been used to aid in the diagnosis of ETD and to assess its severity. Temporomandibular joint disorder (TMJD) is a common condition that causes similar symptoms to ETD and has been recognized as a potential confounding condition in patients presenting with ETD symptoms. We sought to determine the cross‐sectional prevalence of ETD symptoms in patients with TMJD using the ETDQ‐7.Study DesignProspective cross‐sectional analysis.MethodsAn analysis was performed of ETDQ‐7 scores in patients diagnosed with TMJD.ResultsA total of 21 patients with confirmed TMJD completed the ETDQ‐7 at routine consult or follow‐up for their TMJD. The mean ± standard deviation ETDQ‐7 score for the cohort was 24.5 ± 12.5. Two‐thirds of patients had an ETDQ‐7 score of >14.5, which has been used in the literature to denote clinically significant ETD. No single question was scored significantly higher than the others.ConclusionsSymptoms of ETD are highly prevalent among patients with TMJD determined by patient‐reported outcome measures. It is not clear if these symptoms reflect true derangement of eustachian tube function in these patients or whether there is only clinical similarity between ETD and TMJD. However, future research efforts may resolve this dilemma.Level of Evidence4 Laryngoscope, 130:E233–E236, 2020
The role of T‐cell protein tyrosine phosphatase in epithelial carcinogenesis
Authors: Morales Liza D. , Archbold Anna K. , Olivarez Serena , Slaga Thomas J. , DiGiovanni John , Kim Dae Joon 
Published: July 2019

AbstractT‐cell protein tyrosine phosphatase (TC‐PTP, encoded by PTPN2) is a nonreceptor PTP that is most highly expressed in hematopoietic tissues. TC‐PTP modulates a variety of physiological functions including cell cycle progression, cell survival and proliferation, and hematopoiesis through tyrosine dephosphorylation of its target substrates, such as EGFR, JAK1, JAK3, STAT1, and STAT3. Studies with whole or tissue‐specific loss of TC‐PTP function transgenic mice have shown that TC‐PTP has crucial roles in the regulation of the immune response, insulin signaling, and oncogenic signaling. More recently, the generation of epidermal‐specific TC‐PTP‐deficient mice for use in multistage skin carcinogenesis bioassays demonstrated that TC‐PTP suppresses skin tumor formation by negatively regulating STAT3 and AKT signaling. Further investigation showed that TC‐PTP also minimizes UVB‐induced epidermal cell damage by promoting apoptosis through the negative regulation of Flk‐1/JNK signaling. These findings provide major evidence for a tumor suppressive function for TC‐PTP against environment‐induced skin cancer. Here, we will discuss TC‐PTP, its substrates, and its functions with an emphasis on its role in skin carcinogenesis.
Multicriteria optimal operation of a microgrid considering risk analysis, renewable resources, and model predictive control
Authors: Zafra‐Cabeza Ascensión , Velarde Pablo , Maestre José M. 
Published: July 2019

SummaryThis paper proposes an optimal power dispatch by taking into account risk management and renewable resources. In particular, it examines how control engineering and risk management techniques can be applied in the field of power systems through their use in the design of risk‐based model predictive controllers. To this end, this paper proposes a two‐layer control scheme for microgrid management where both levels are based on model predictive control (MPC): the higher level is devoted to risk management while the lower layer is dedicated to power dispatching. In particular, the high‐level controller is based on a risk‐based approach where potential risks have been identified and evaluated. Mitigation actions are the decision variables to be optimized to reduce the consequences of risks and costs. The MPC‐based algorithm decides the appropriate frequency of mitigation actions such as changes in references, constraints, and insurance contracting, by relying on a model that includes integer variables, identifiable risks, their costs, and the cost/benefit assessment of mitigating actions. On the other hand, the low‐level controller drives the plant to suitable values to satisfy demands. A series of simulations on a nonlinear model of a real laboratory‐scale power plant located in the facilities of the University of Seville are conducted under varying conditions to demonstrate the effectiveness of the algorithm when risks are explicitly considered.
Enhanced Activity and Substrate Specificity by Site‐Directed Mutagenesis for the P450 119 Peroxygenase Catalyzed Sulfoxidation of Thioanisole
Authors: Wei Xiaoyao , Zhang Chun , Gao Xiaowei , Gao Yanping , Yang Ya , Guo Kai , Du Xi , Pu Lin , Wang Qin 
Published: July 2019

AbstractP450 119 peroxygenase was found to catalyze the sulfoxidation of thioanisole and the sulfonation of sulfoxide in the presence of tert‐butyl hydroperoxide (TBHP) for the first time with turnover rates of 1549 min−1 and 196 min−1 respectively. Several mutants were designed to improve the peroxygenation activity and thioanisole specificity by site‐directed mutagenesis. The F153G/T213G mutant gave an increase of sulfoxide yield and a decrease of sulfone yield. Moreover the S148P/I161T/K199E/T214V mutant and the K199E mutant with acidic Glu residue contributed to improving the product ratio of sulfoxide to sulfone. Addition of short‐alkyl‐chain organic acids to the P450 119 peroxygenase‐catalyzed sulfur oxidation of thioanisole was investigated. Octanoic acid was found to induce a preferred sulfoxidation of thioanisole catalyzed by the F153G/T213G mutant to give approximately 2.4‐fold increase in turnover rate with a kcat value of 3687 min−1 relative to that of the wild‐type, and by the F153G mutant to give the R‐sulfoxide up to 30 % ee. The experimental control and the proposed mechanism for the P450 119 peroxygenase‐catalyzed sulfoxidation of thioanisole in the presence of octanoic acid suggested that octanoic acid could partially occupy the substrate pocket; meanwhile the F153G mutation could enhance the substrate specificity, which could lead to efficiently regulate the spatial orientation of thioanisole and facilitate the formation of Compound I. This is the most effective catalytic system for the P450 119 peroxygenase‐catalyzed sulfoxidation of thioanisole.
Blinatumomab as a bridge to further therapy in cases of overwhelming toxicity in pediatric B‐cell precursor acute lymphoblastic leukemia: Report from the Israeli Study Group of Childhood Leukemia
Authors: Elitzur Sarah , Arad‐Cohen Nira , Barzilai‐Birenboim Shlomit , Ben‐Harush Miriam , Bielorai Bella , Elhasid Ronit , Feuerstein Tamar , Gilad Gil , Gural Alexander , Kharit Mira , Litichever Naomi , Nirel Ronit , Weinreb Sigal , Wolach Ofir , Toren Amos , Izraeli Shai , Jacoby Elad 
Published: July 2019

AbstractTremendous progress in the therapy of pediatric acute lymphoblastic leukemia (ALL) has been achieved through combination cytotoxic chemotherapy, leading to high cure rates, at the cost of significant life‐threatening toxicity. The bispecific T‐cell engager blinatumomab, recently approved for relapsed/refractory ALL, has a unique nonmyelotoxic toxicity profile. As blinatumomab causes B‐cell depletion, the safety of its use during severe chemotherapy‐induced toxicity is unclear. We report 11 pediatric patients with ALL, treated with blinatumomab following overwhelming chemotherapy‐associated toxicity, with recovery of all patients and successful bridging to further antileukemia therapy. Blinatumomab can be considered for rare patients who cannot tolerate cytotoxic therapy.
Children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor in Norway from 1974 through 2013: Unexplainable regional differences in survival
Authors: Stensvold Einar , Myklebust Tor Åge , Cappelen Johan , Due‐Tønnessen Bernt J. , Due‐Tønnessen Paulina , Kepka Aleksandra , Johannesen Tom Børge , Krossnes Bård , Lundar Tryggve , Maric Snezana , Miletic Hrvoje , Moholdt Viggo , Myrmel Kristin Smistad , Nordberg Terje , Rydland Jana , Stokland Tore , Solem Kristin , Solheim Ole , Torsvik Ingrid , Wikran Gry C. , Zeller Bernward , Wesenberg Finn , Bechensteen Anne Grete , Brandal Petter 
Published: July 2019

AbstractBackgroundA previous study based on Norwegian Cancer Registry data suggested regional differences in overall survival (OS) after treatment for medulloblastoma (MB) and supratentorial primitive neuroectodermal tumor (CNS‐PNET) in Norway. The purpose of the present study was to confirm in an extended cohort whether there were regional differences in outcome or not, and if so try to identify possible explanations.Material and methodsData from patients aged 0–20 years diagnosed with and treated for MB/CNS‐PNET at all four university hospitals in Norway from 1974 to 2013 were collected and compared.ResultsOf 266 identified patients, 251 fulfilled inclusion criteria. MB was diagnosed in 200 and CNS‐PNET in 51 patients. Five‐year OS and event‐free survival (EFS) were 59% and 52%, respectively. There was a significant difference in five‐year OS and EFS between MB and CNS‐PNET patients; 62% versus 47% (P = 0.007) and 57% versus 35% (P < 0.001). In multivariable analysis, two factors were found to significantly contribute to improved five‐year OS and EFS, whereas one factor contributed to improved five‐year OS only. Gross total resection (GTR) versus non‐GTR (hazard ratio [HR] 0.53, P = 0.003; HR 0.46, P < 0.001) and cerebrospinal irradiation (CSI) versus non‐CSI (HR 0.24, P < 0.001; HR 0.28, P < 0.001) for both, and treatment outside Oslo University Hospital for OS only (HR 0.64, P = 0.048).ConclusionSurvival was comparable with data from other population‐based studies, and the importance of GTR and CSI was confirmed. The cause for regional survival differences could not be identified.
Restoring meaning in life by meaning‐focused coping: The role of self‐distancing
Authors: Wang Yu , Lippke Sonia , Miao Miao , Gan Yiqun 
Published: July 2019

AbstractMeaning‐focused coping is an important coping strategy in the face of stressful life events. The “construal level theory” and recent research suggest that reflecting on a stressful situation from a self‐distanced stance (temporal or spatial) allows individuals to find meaning in negative life events; however, its long‐term effects have not yet been explored. The present research had two main goals: (1) to determine whether distanced meaning making enhances meaning in life and (2) to explore the underlying emotional mechanism of this effect. We hypothesized that positive affect (relative to negative affect) may play a more important role in the relationship between self‐distanced meaning making and meaning in life. A total of 136 university students were recruited as participants in two studies. The participants were prospectively instructed to make meaning of a highly stressful event. They were randomly assigned to one of three conditions: (a) self‐immersed, (b) temporally distanced, or (c) spatially distanced. The findings indicate that both the temporally and spatially distanced perspectives in the meaning‐making process can enhance meaning in life and that they do so by promoting positive affect. Implications for future research on meaning‐focused coping and self‐distancing are discussed.
Synthesis of a novel copolymer using glycogen and poly(lactide) as a carrier of dual drugs—ornidazole and ofloxacin
Authors: Patra Priyapratim , Soni Saundray Raj , Seesala Venkata Sundeep , Dhara Santanu , Ghosh Animesh , Pal Sagar 
Published: July 2019

ABSTRACTBiodegradability and biocompatibility are two crucial prerequisites for a promising therapeutic vehicle. Herein, a novel biocompatible copolymer has been synthesized using glycogen and polylactide (PLA). Glycogen, a naturally occurring biopolymer has been functionalized by methacrylation. On the other hand, lactide has been polymerized through ring opening polymerization (ROP), initiated by hydroxyethyl methacrylate (HEMA) and catalyzed by tin (II) 2‐ethyl hexanoate. Finally, the synthesized two substrates (i.e., glycogen methacrylate and PLA‐HEMA) are covalently connected by free‐radical polymerization, initiated by AIBN. The structure of the developed copolymer has been confirmed using 1H and 13C NMR spectral analyses. The gel characteristics have been evaluated by rheological studies, while the morphological assessment has been investigated by FESEM analysis. In vitro cytocompatibility study reveals that the hydrogel (Gly‐co‐PLA) is biocompatible. The in vitro and in vivo release studies demonstrate the excellent pH‐sensitive control release profile of dual drugs: ornidazole and ofloxacin. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1697–1703
Fertility treatments and the risk of pediatric obstructive sleep apnea in the offspring—Results from a population‐based cohort study
Authors: Imterat Majdi , Wainstock Tamar , Sheiner Eyal , Landau Daniella , Walfisch Asnat , Harlev Avi 
Published: July 2019

AbstractObjectiveWhile the impact of fertility treatments on the perinatal outcome is well established, the long‐term effects on offspring are yet to be determined. The current study aimed to investigate the risk of long‐term obstructive sleep apnea (OSA) among children born following in vitro fertilization (IVF) and ovulation induction (OI) as compared with spontaneously conceived pregnancies.Study designA retrospective population‐based cohort study was performed. Exposure was defined as delivery following pregnancies conceived by IVF or OI. Incidence of OSA related hospitalizations of the offspring, up to the age of 18 years, was evaluated. A Kaplan‐Meier survival curve and multivariable Cox regression models were used to assess the association.ResultsDuring the study period, 242 187 singleton deliveries met the inclusion criteria; 1.1% were conceived following IVF (n = 2603), and 0.7% following OI (n = 1721). Offspring hospitalization rates, involving OSA (n = 1607), were higher among children conceived following IVF and OI pregnancies as compared with the rate in children conceived spontaneously (1.4% vs 1.2% vs 0.7%, respectively; P < .001). The Kaplan‐Meier survival curve demonstrated a significantly higher cumulative incidence of OSA related hospitalizations following IVF and OI (log‐rank P < .001). Using multiple Cox regression models, controlled for gestational age, maternal age, maternal smoking, maternal obesity, birthweight, offspring gender and obesity, IVF as well as OI exhibited a significant and independent association with pediatric OSA in all models with adjusted hazard ratios of 2.25, (95% confidence interval [CI] = 1.6‐3.1) and 1.63 (95% CI = 1.1‐2.5), respectively.ConclusionBoth IVF and OI treatments appear to be independently associated with OSA in the offspring.
A biotinylated peptide, BP21, alleviates hypotension in anaphylactic mice
Authors: Sato Akira , Ebina Keiichi 
Published: July 2019

Platelet‐activating factor (PAF) is known as an important mediator of anaphylaxis and, therefore, may possibly serve as a direct target for anti‐anaphylactic drugs. We recently reported that a synthetic N‐terminally biotinylated peptide, BP21, alleviates hypothermia and vascular hyperpermeability during anaphylactic reactions in a mouse model of anaphylaxis via the direct binding of a Tyr‐Lys‐Asp‐Gly sequence in the peptide to PAF. In this study, we investigated the effect of BP21 on in vivo anaphylactic hypotension. Results showed that BP21 significantly inhibited anaphylactic hypotension in a dose‐dependent manner, with peak severity being reached within 20 minutes. Adrenaline, which is the recommended first line treatment for anaphylactic patients, did not inhibit anaphylactic hypothermia. The combined administration of BP21 with adrenaline inhibited both hypotension and hypothermia, even at both low doses, more effectively compared with solo administration of BP21 or adrenaline. These results suggested that BP21 could potentially be a novel anti‐anaphylactic agent for targeting PAF in vivo.
Hesperidin improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo‐controlled, double‐blind clinical trial
Authors: Cheraghpour Makan , Imani Hossein , Ommi Shahrzad , Alavian Seyed Moayed , Karimi‐Shahrbabak Elahe , Hedayati Mehdi , Yari Zahra , Hekmatdoost Azita 
Published: July 2019

This study aimed to evaluate the effects of hesperidin on nonalcoholic fatty liver disease (NAFLD) characteristics. In this randomized, double‐blind, controlled clinical trial, 50 NAFLD patients were supplemented with either 1‐g hesperidin capsule or identical placebo capsule for 12 weeks. During the intervention, both groups were advised to follow healthy lifestyle habits including dietary and physical activity recommendations. At the end of the study, hesperidin supplementation, compared with placebo, was associated with a significant reduction in alanine aminotransferase (p = .005), γ‐glutamyltransferase (p = .004), total cholesterol (p = .016), triglyceride (p = .049), hepatic steatosis (p = .041), high‐sensitivity C‐reactive protein (p = .029), tumor necrosis factor‐α, and nuclear factor‐κB (NF‐κB). In conclusion, our results indicate that hesperidin supplementation accompanied with lifestyle modification is superior to lifestyle modification alone in management of NAFLD at least partially through inhibiting NF‐κB activation and improving lipid profile. Further studies with higher dose of hesperidin are required to find the optimal dose.
A sequential weighted Laplacian‐regularized optimal design for response surface modeling of expensive functions with outliers: An application in linear elastic fracture mechanics
Authors: Martinez Stanford , Alaeddini Adel , Langer Kristina 
Published: July 2019

AbstractThere are several sequential and adaptive strategies designed to reduce the number of experiments in response surface methodology (RSM). However, most of the existing sequential and adaptive methods are sensitive to the existence of possible outliers. In this paper, we propose an active learning methodology based on the fundamental idea of adding a Laplacian penalty to the D‐optimal design and integrate that with robust regression to look for the most informative settings to be measured, while reducing the influence of possible outliers. To leverage the intrinsic geometry of the factor settings in highly nonlinear spaces, we extend the proposed methodology to reproducing Kernel Hilbert space (RKHS). Through an extensive simulation study accompanied by a thorough sensitivity analysis, we show that the proposed framework outperforms traditional RSM designs in the presence of outliers. We also conduct a study utilizing a hierarchical function used in linear elastic fracture mechanics to illustrate practicality of the proposed methodology.
Stochastic synchronization of delayed multiagent networks with intermittent communications: An impulsive framework
Authors: Ma Tiedong , Cui Bing , Wang Yujuang , Liu Kun 
Published: July 2019

SummaryThis paper investigates the stochastic synchronization problem of delayed multiagent networks with intermittent communications. Two kinds of impulsive effects are taken into account, ie, impulsive controller (positive impulsive effect) and impulsive disturbance (negative impulsive effect). Impulsive controller allows the synchronization to be realized and requires only state information exchange at discrete time instants such that the communication cost of bandwidth is reduced. Meanwhile, impulsive disturbance is inevitable in most of practical systems and therefore is taken into consideration at discrete time instants. Sufficient conditions for synchronization are given in terms of the graph topology, the control coupling gains, and the individual agent dynamics parameters, which indicates that synchronization can be realized if the impulsive effects coefficients and communication rate are suitably selected. Simulation results verify the effectiveness of the proposed synchronization protocol.
Triphenylene‐Derived Electron Acceptors and Donors on Ag(111): Formation of Intermolecular Charge‐Transfer Complexes with Common Unoccupied Molecular States
Authors: Müller Kathrin , Schmidt Nico , Link Stefan , Riedel René , Bock Julian , Malone Walter , Lasri Karima , Kara Abdelkader , Starke Ulrich , Kivala Milan , Stöhr Meike 
Published: July 2019

AbstractOver the past years, ultrathin films consisting of electron donating and accepting molecules have attracted increasing attention due to their potential usage in optoelectronic devices. Key parameters for understanding and tuning their performance are intermolecular and molecule–substrate interactions. Here, the formation of a monolayer thick blend of triphenylene‐based organic donor and acceptor molecules from 2,3,6,7,10,11‐hexamethoxytriphenylene (HAT) and 1,4,5,8,9,12‐hexaazatriphenylenehexacarbonitrile (HATCN), respectively, on a silver (111) surface is reported. Scanning tunneling microscopy and spectroscopy, valence and core level photoelectron spectroscopy, as well as low‐energy electron diffraction measurements are used, complemented by density functional theory calculations, to investigate both the electronic and structural properties of the homomolecular as well as the intermixed layers. The donor molecules are weakly interacting with the Ag(111) surface, while the acceptor molecules show a strong interaction with the substrate leading to charge transfer and substantial buckling of the top silver layer and of the adsorbates. Upon mixing acceptor and donor molecules, strong hybridization occurs between the two different molecules leading to the emergence of a common unoccupied molecular orbital located at both the donor and acceptor molecules. The donor acceptor blend studied here is, therefore, a compelling candidate for organic electronics based on self‐assembled charge‐transfer complexes.
α‐Ni(OH)2 Originated from Electro‐Oxidation of NiSe2 Supported by Carbon Nanoarray on Carbon Cloth for Efficient Water Oxidation
Authors: Wang Ling , Wang Xiaopeng , Xi Shibo , Du Yonghua , Xue Junmin 
Published: July 2019

AbstractDevelopment of effective oxygen evolution reaction (OER) electrocatalysts has been intensively studied to improve water splitting efficiency and cost effectiveness in the last ten years. However, it is a big challenge to obtain highly efficient and durable OER electrocatalysts with overpotentials below 200 mV at 10 mA cm−2 despite the efforts made to date. In this work, the successful synthesis of supersmall α‐Ni(OH)2 is reported through electro‐oxidation of NiSe2 loaded onto carbon nanoarrays. The obtained α‐Ni(OH)2 shows excellent activity and long‐term stability for OER, with an overpotential of only 190 mV at the current density of 10 mA cm−2, which represents a highly efficient OER electrocatalyst. The excellent activity could be ascribed to the large electrochemical surface area provided by the carbon nanoarray, as well as the supersmall size (≈10 nm) of α‐Ni(OH)2 which possess a large number of active sites for the reaction. In addition, the phase evolution of α‐Ni(OH)2 from NiSe2 during the electro‐oxidation process was monitored with in situ X‐ray absorption fine structure (XAFS) analysis.