bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of advanced fibrosis in elderly patients with biopsy-confirmed nonalcoholic fatty liver disease: The GOASIA study
Authors: Pitisuttithum Panyavee , Chan Wah Kheong , Piyachaturawat Panida , Imajo Kento , Nakajima Atsushi , Seki Yosuke , Kasama Kazunori , Kakizaki Satoru , Fan Jian Gao , Song Myeong Jun , Yoon Seung Kew , Dan Yock Young , Lesmana Laurentius , Ho Khek Yu , Goh Khean Lee , Wong Vincent Wai Sun , Treeprasertsuk Sombat 
Published: August 2019

Abstract
Background and Aim

The Gut and Obesity in Asia (GOASIA) Workgroup was formed to study obesity and gastrointestinal diseases in the Asia Pacific region. We aimed to 1) compare the characteristics of elderly (i.e. age ≥ 60) vs. non-elderly patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD); 2) identify predictors of advanced fibrosis in elderly patients with NAFLD; and 3) assess the performance of non-invasive fibrosis scores in the prediction of advance fibrosis in the elderly population.

Methods

We abstracted the data of 1008 patients with NAFLD from nine centers across eight countries. Characteristics of elderly and non-elderly patients with NAFLD were compared using 1:3 sex-matched analysis.

Results

Of the 1008 patients, 175 were elderly (age 65±4 years), who were matched with 525 non-elderly patients (44±11 years). Elderly patients were more likely to have advanced fibrosis (35.4% vs. 13.3%; p<0.001). By multivariable analysis, factors associated with advanced fibrosis in elderly patients included female sex (odds ratio [OR] 3.21; 95% confidence interval [CI] 1.37-7.54) and hypertension (OR 3.68; 95%CI 1.11-12.23). The area under receiver-operating characteristics curve (95% CI) of aspartate aminotransferase-to-platelet ratio index, NAFLD fibrosis score and Fibrosis-4 index for predicting advanced fibrosis in elderly patients were 0.62 (0.52-0.72), 0.65 (0.55-0.75) and 0.64 (0.54-0.74) respectively.

Conclusions

Elderly patients with NAFLD had a higher prevalence of advanced fibrosis than non-elderly patients. Female and hypertension were predicting factors for advanced fibrosis in the elderly. Non-invasive fibrosis scores had a lower specificity in elderly.
Improving management of glycaemic control in people with T2DM in Primary Care: estimation of the impact on the clinical complications and associated costs
Authors: Mata-Cases Manel , Mahon James , Mauricio Didac , Franch-Nadal Josep , Real Jordi , Hex Nick 
Published: August 2019

Abstract
Aim To estimate the potential benefits in terms of avoided complications and cost reduction if the Spanish health system would encourage the intensification of treatment for better glycaemic control in adults with Type 2 diabetes from the current HbA1c target used in clinical practice of 68 mmol/mol to a target of 53 mmol/mol. Methods The IQVIA Core Diabetes Model (version 9.0) was used to model the impact of these changes in respect of micro- and macrovascular complications and the associated costs. The modelling was based on data derived from the SIDIAP-Q population database from Catalonia, taking a random cohort of 10,000 people with type 2 diabetes and dividing it into sub-groups based on their basal HbA1c. Results The CDM modelling showed that the average cost reduction per person varies depending on basal HbA1c. The model estimates that after 25 years, people with a basal HbA1c between 48 and 58 mmol/mol and >75 mmol/mol show an average cost reduction of €6,027 and €11,966, respectively. Applying the per-person cost reduction to the cohorts of the prevalent population in Spain (1,910,374) the overall estimated cost reduction was €14.7 billion over 25 years. The improvements in outcomes resulted in an estimated reduction of more than 1.2 million complications cumulatively over 25 years, of which more than 550,000 relate to diabetic foot and more than 170,000 related to renal disease. Conclusion Over a 25 year period, Spain could considerably reduce costs and avoid major complications if, on a population level, more ambitious glycaemic control, according to Spanish or EU guidelines, could be achieved among people with type 2 diabetes by reducing the HbA1c threshold for treatment intensification. Although there is a slower trajectory for benefits in earlier years, there is a much more rapid benefit gain between years 5 and 15.
Determining the Psychosocial Needs of ElderlyPeople Living in the Turkish Republic of Northern Cyprus
Authors: esmaeilzadeh samineh , Oz Fatma 
Published: August 2019

Abstract
Background:The Turkish Republic of Northern Cyprus (T.R.N.C.) is an island country that has experienced war due to its geographical location, and which has had a tragic recent history. It is believed that those who are currently elderly mayface many psychosocial problems as individuals who have experiencing this historical process.Identifying these psychosocial problems will help to planpsychiatric services for these individuals.

Methods: The data was collected through focus group interviews, which are a qualitative research method. 20 elderly people aged 65 and above living in Northern Cyprus were interviewed on a voluntary basis. Therewere 6-8 people in each focus group. A questionnaire developed by the researchers was utilised during the interviews.

Results:After the focus group interview, we divided the results into four categories (psychological, spiritual, physical and socialneeds) and 12 sub-themes:thepsychological categorycontainedlosses and emotional loneliness, risk of depression and adaptation to being elderly; thespiritual categorycontained anxiety aboutdeath, and beliefs, values and culture; thesocial category containedchange in roles, change in expectations, family problems and loneliness, and the physical category containedphysical impairment due to elderliness and illnesses.

Conclusion:When comprehensive and realistic information is collected regarding the psychosocial needs and problems of elderly individuals, problems that are currently tending to increase, and the expectations of elderly people are properly understood, it is possible to develop new practical models that contribute to the enhancement of services for the elderly.
Characterization and genome analysis of novel phage vB_KpnM _Bp5 infecting Klebsiella pneumonia
Authors: Zhang Cong , Ge Chenling , Wang Xiaoye , Wei Deyuan , Li Xun , Si Hongbin , Hu Chuanhuo 
Published: August 2019

Abstract
Background With the incidence of antibiotic resistance reaching crisis point, it is imperative to find alternative treatments for multidrug-resistant infections. Using phage for pathogen control might be a promising treatment option to combat bacterial resistance. Results In this study, a lytic phage, designated vB_KpnM _Bp5, was isolated from pig faecal sample in Nanning, Guangxi province of China, and classified as a member of the family Muscle virus based on electron microscopy analysis. A one-step growth curve of the phage at the optimal MOI revealed that the latent time was 40 min and the burst size was 24 PFU/cell, indicative of good lysis capacity. Whole genome sequencing showed that phage vB_KpnM _Bp5 had a small dsDNA genome of 43872 bp. BLASTn analysis showed that it shared 94.06% identity (94% genome coverage) with Klebsiella phage vB_KpnP_SU552A of complete genome idefix. RAST genome analysis showed that the phage had 50 ORFs due to its small genome size, and the number of functional proteins was consistent with other phages. To evaluate the therapeutic effect of Klebsiella pneumoniae infection in mice, the results showed that phages provided vB_KpnM _Bp5better protection. Conclusion The phage vB_KpnM _Bp5 had the characteristics of broad host spectrum, strong environmental adaptability, short incubation period, large outbreak amount, and can cure the mouse model infected by Klebsiella pneumoniae. These findings suggested that phage vB_KpnM _Bp5 could be considered a potential therapeutic or prophylactic candidate against Klebsiella pneumonia infection.
Fast Feedback? Managing vulnerability in Emergency Departments through continuous improvement
Authors: Mateo Ricardo , Neriz Liliana , Ramis Francisco , Núñez Alicia , Bustamante Hernan , Mateo Carmen 
Published: August 2019

Abstract
Background Waiting time for physician attention is considered emergency care–sensitive, but still many emergency departments (EDs) attend their patients outside of the standard recommended. Objectives The objective of this research is to make a contribution for managing continuous improvement in EDs based on providing fast feedback using a new normalized variable named vulnerability. Methods This research has analyzed the levels of census, efficiency and vulnerability with which an ED works. The data set contains information regarding 53,175 individuals attended in an ED in Chile during 2013. A regression model was conducted to explain vulnerability. In order to carry out the analysis census, efficiency and vulnerability variables were calculated for each patient attended. The model has explained 63% of vulnerability. Results 40% of ED patients were attended after the wait time recommended by ESI and with efficiency levels lower than 40%. According to our results, efficiency, census, diagnostic track and months explain vulnerability. Conclusions This study allows us to manage EDs by using a new variable named vulnerability. Vulnerability provides fast feedback for healthcare professionals in order to develop a continuous improvement policy. This could increase professional commitment for continuous improvement and therefore decrease morbidity and mortality in any ED.
Low Adherence To Hand Hygiene: Analysis Of The Impact Factors In Critical Sectors Of A Hospital
Authors: Valim Marília Duarte , Bezerra Thaissa Blanco , Sousa Alvaro Francisco Lopes , Andrade Denise de , Ferreira Adriano Menis , Almeida Willian Alburquerque de , Rigotti Marcelo Alessandro , Bortolini Juliano 
Published: August 2019

Abstract
Background: We aimed to monitor hand hygiene (HH) of health professionals in three critical sectors of a university hospital, to verify the physical structure of these units for HH, gloves use and perception of professionals regarding the patient's safety climate
Methods: An observational, correlational study, conducted in critical sectors of a hospital. The study population consisted of nurses, nursing technicians, physicians, resident physicians and physiotherapists. The data were collected through four questionnaires to evaluate HH, factors related to adherence to it and sociodemographic characteristics. Results: A total of 148 professionals and 3.025 opportunities for HH were observed. Adherence to HH was higher among nurses when compared to nursing professionals (p <0.05), and there was a difference between different sectors (p <0.05). Professionals who previously participated in training had greater adherence (47.79% CI95% 45.38-50.20) to HH than professionals who did not participate (44.62% CI95% 41.95-47.29). There was a statistical difference between the perception of the security climate and the type of employment bond of the professional, as well as the sector in which it operates. Conclusion: Adherence to HH was affected and / or influenced by the physical structure, use of procedure gloves, work regimen and perceived patient safety climate.
Keywords: Hand hygiene; Cross Infection; Patient Safety; Safety culture
Pseudomonas aeruginosa in public water supply
Authors: Anversa Laís , Arantes Stancari Regina Célia , Garbelotti Maricene , da Silva Ruiz Luciana , Pereira Virgínia Bodelão Richini , Nogueira Nascentes Gabriel Antonio , Alves Dantas Stéfani Thais , Mores Rall Vera Lúcia 
Published: August 2019

Abstract
Water is indispensable for life and its quality is directly related to public health. The objective of this study was to investigate the presence of Pseudomonas aeruginosa in public water supply in municipalities in São Paulo State, Brazil. Analyses were carried out at the Adolfo Lutz Institute between February and December 2016, and included physicochemical (chlorine, pH, color, turbidity and nitrate), and microbiological parameters (total coliforms and Escherichia coli), as well as P. aeruginosa, with susceptibility tests to antimicrobial agents and biofilm production capacity by the strains isolated. In total, 251 water samples were evaluated and 19 (7.6%) presented P. aeruginosa. No significant differences were observed between the physicochemical parameters found in the positive and negative samples for this bacterium, but the samples containing total coliforms were also those with the highest positivity for P. aeruginosa. All samples with P. aeruginosa reported chlorine concentrations between 0.2 and 2.0 mg/L, as required by Brazilian legislation, demonstrating this bacterium's resistance to conventional water treatment processes. Although not resistant to the antimicrobials tested, most strains isolated were classified as strong biofilm producers, emphasizing the need for further studies involving water supply quality.
INFLUENCE OF THE GLOBAL FINANCIAL CRISIS ON THE SEPARATIST ASPIRATIONS OF CATALONIA FROM THE PERSPECTIVE OF SPANISH INTERNAL LAW
Authors: Dankowski Michał Zbigniew 
Published: August 2019

The Catalan Crisis of 2017-2018 has shown significant misunderstandings in the internal legal system of Spain. Many issues of the legal system were differently understood by the central government and by the autonomous authorities in Barcelona. It concerned such as important issues like the institution of referendum, which was interpreted differently by politicians from Madrid and the Constitutional Court and otherwise by those from Barcelona. The genesis of the constitutional crisis itself is rooted in the global economic crisis that began in the second half of the last decade, as it was then that the Catalan nationalist movement radicalized.
Facial anthropometry in an adult male with Sotos syndrome
Authors: Carvalho Eliza Cristiane de , Bisson Amanda Albino , Hespanhol Lucas Alvarenga , Pereira Nicoli Maria , Fregoneze Andrea Paula , Brancher João Armando , Torres Maria Fernanda Pioli 
Published: August 2019

Introduction: Sotos Syndrome is a dominant autossomic disease caused by a mutation in NSD1 gene localized in chromosome 5. The craniofacial phenotype of Sotos Syndrome is quite distinctive, especially in the young child, and includes macrocephaly, widelyspaced eyes, prominent chin and mandible, high and curved forehead, palpebral slits oblique and downward, long and narrowface. This phenotype plays an important role in the identification of this syndrome. Objective: The aim of this study was to analyze the craniofacial anthropometric landmarks of a young adult male with medical diagnosis of Sotos Syndrome. Material and methods: Using noninvasive method of craniofacial anthropometry, twenty five anthropometric measurements were taken of the individual and compared with the facial pattern of non-syndromic individuals,matched in gender and age. The findings were standards and converted to Z-scores. Results: the data analysis showed that the majority of variables were in supernormal range (greater than +2 standard deviation (SD). None none of them was in the subnormal range (less than –2SD). Conclusion: Anthropometric analysis of Sotos Syndrome demonstrated the usefulness of craniofacial analysisin defining abnormal craniofacial dimensions.
Neutrophils as Sentinel Cells of the Immune System: A Role of the MPO-halide-system in Innate and Adaptive Immunity
Authors: Marcinkiewicz Janusz , Walczewska Maria 
Published: August 2019

:For decades, neutrophils were generally regarded as the cells of innate immunity with proinflammatory and phagocytic properties involved in a dual activity, beneficial (antimicrobial) and detrimental (tissue damage). Importantly, until the discovery of toll-like receptors (TLRs), a role of neutrophils in adaptive immunity was limited to the effector stage of humoral response and phagocytosis of opsonized antigens. Moreover, in common opinion, neutrophils, as well as the entire innate immune system, were not functionally associated with adaptive immunity. At the time we demonstrated protein chlorination by HOCl, the major product of neutrophil MPO-halide system enhances protein immunogenicity. Based on this discovery, we proposed, as the first, a new role for neutrophils as APC-accessory cells involved in the induction stage of adaptive immunity. Thereafter, we developed our theory concerning the role of neutrophils as the cells which link innate and adaptive immunity. We proposed that protein modification by HOCl may act as a neutrophildependent molecular tagging system, by which sentinel dendritic cells can faster recognise pathogen- derived antigens. Contemporaneously, it was demonstrated that taurine, the most abundant free amino acid in neutrophil cytosol and the major scavenger of HOCl, is a part of the oxidantantioxidant network and is responsible for the regulation and termination of acute inflammation. Moreover, it has been described, that taurine chloramine (TauCl), the physiological products of the reaction of HOCl with taurine, show anti-microbial and anti-inflammatory properties.:In this review, the role of HOCl, taurine and TauCl in innate and adaptive immunity will be discussed.
The Impact of Working Memory Training on Cognitive Abilities in Older Adults: The Role of Cognitive Reserve
Authors: Mičič Sara , Horvat Marina , Bakracevic Karin 
Published: August 2019

Objectives:
The aims of this study were to determine whether Working Memory (WM)
training improves the cognitive functioning of older adults and to determine the role of cognitive
reserve in WM training.

Method:
Twenty-one older adults, aged between 65 and 91 years were included in the study. Ten
of them were in the experimental group and 11 in the passive control group. The experimental
group underwent 15 training sessions of n-back training over a period of five weeks, whereas the
control group remained passive. All participants (from the experimental and control group) were
tested before the training, one week after the training, and three months after the training with Rey–
Osterrieth/Taylor Complex Figure test (ROCF), Digit span, and TMT (part A and part B).

Results and Conclusion:
Results of our study suggest that although the experimental group slightly
improved their performance on the trained task, the progress was not statistically significant. There
was also no statistically significant transfer of training effects onto tasks of visual-spatial and verbal
memory, as well as those related to executive functioning. However, the study did identify a statistically
significant correlation between cognitive reserve and certain tests performed at the final testing:
tasks measuring executive functioning and spatial ability. Results also revealed that the group
that showed improvement in the training task was significantly better in the ROCF test in comparison
with the group that had not improved their performance on the N-back task. Thus, visual-spatial
abilities (visual perception, construction, and memory) were more connected with success in WM
training, than other measured cognitive abilities (e.g. verbal and numerical memory).
Enhancement of Separated Ultra Pure n-paraffin as Phase Change Materials (PCM) by W-Fe Bimetallic Oxides
Authors: Soliman Fathi S. , El-Maghrabi Heba H. , Zaki Tamer , Nada Amr A. , Zahran Fouad 
Published: August 2019

Objective::
Six ultra pure Paraffin Waxes (PW) were successfully fractionated at 35°,
30°, 25°, 20°, 15° and 10°C. The bimetallic oxide (Ferberite) was successfully synthesized by Microwave
assisted method.

Methods:
Enhanced Phase Change Materials (PCMs) were designed by loading W/Fe bimetallic
oxides in the ultra pure PW matrix at 1, 2, 3, 4 and 5 wt. %. paraffin wax, W/Fe bimetallic oxide
and the resultant composite blends were characterized by X-ray Diffraction (XRD), Gas Chromatography
(GC), Deferential Scanning Calorimetry (DSC), Polarized Optical Microscope (POM),
Scanning Electron Microscopy (SEM) and High Resolution Transmission Electron Microscopy
(HRTEM). In addition to testing the thermal conductivity of the designed blends. According to
SEM, DSC and POM data, the prepared nanocomposite was homogeneously dispersed into the
selected PW matrix.

Results:
Data revealed that thermal conductivity of the designed composite increases with increasing
the loading ratio of W-Fe bimetallic oxides. The total latent heat storage ΔHT of the initial
sample was improved from 295.91 J/g to 311.48 J/g at 5 wt. % loading percent.

Conclusion::
Thermal conductivity was improved from 8.54 to 21.77 W/m2k with increasing up to
255% in comparison with pure paraffin wax.
Analysis of Voice Cues in Recognition of Sarcasm
Authors: Hiremath Basavaraj N , Patil Malini M. 
Published: August 2019

Background:
The voice recognition system is about cognizing the signals, by feature extraction
and identification of related parameters. The entire process is referred to as voice analytics.

Objective:
The paper aims at analyzing and synthesizing the phonetics of voice. The work focuses
on the facts of voice analytics i.e. basic blocks of ‘Glottal signature’. The glottal signature and
unique voice cues are evaluated to derive the relationship for utterance of emotional words which
leads to sentimental expression cues. An effort is made to map further to understand sarcasm behavior
in the sounds made by human speech.

Methods:
The basic blocks of unique features identified in the work are Intensity, Pitch, Formants
related to speak, read, interactive and declarative sentences solely on voice cues not on linguistic
theory. It is also tested to identify derived features that maps to fine-grained details of voice cues to
drill up usage in sarcasm detection.

Results:
Different unique features identified in the work are, intensity, pitch, formants related to
read, speak, interactive and declarative sentences and derived parameters.

Conclusion:
The work carried out in the paper also supports the analysis of voice segmentation labelling,
analyzes the unique features of voice cues, understanding physics of voice, the process is
further carried out to recognize sarcasm.
PENGEMBANGAN MEDIA PEMBELAJARAN SEJARAH BERBASIS VISUALISASI MUSEUM SASANA WIRATAMA UNTUK MENINGKATKAN KESADARAN SEJARAH SISWA MAN YOGYAKARTA III
Authors: Basyari Asyhar 
Published: August 2019

AbstrakTujuan penelitian ini 1) Mendeskripsikan media kajian sejarah yang selama ini dilaksanakan di MAN Yogyakarta III 2) Mendeskripsikan rencana studi sejarah ke media Visualisasi Museum Sasana Wiratama yang akan dikembangkan. 3) Mendeskripsikan prosedur pengembang media pembelajaran berbasis Visualisasi Museum Sasana Wiratama untuk meningkatkan Kesadaran akan sejarah siswa 4) Untuk menganalisis sejauh mana efektivitasnya dengan menggunakan studi sejarah dengan menggunakan media pembelajaran berbasis Visualisasi Museum Sasana Wiratama untuk meningkatkan Kesadaran sejarah . Penelitian pengembangan menggunakan metode yang mengadaptasi pengembangan desain ADDIE. Hasil studi uji efektivitas media menunjukkan hasil yang baik. Sehingga dapat ditarik kesimpulan bahwa penggunaan media pembelajaran sejarah berdasarkan visualisasi Museum terbukti efektif Sasana Wiratama dalam meningkatkan prestasi dan kesadaran Sejarah pada siswa. Kata kunci: Pengembangan, Media, Visusalisasi, Sejarah AbstractTarget of this research 1) Describe the media of study of history which during the time executed in MAN Yogyakarta III 2) Describe the plan study of history to media Visualizing Museum Sasana Wiratama to be developed. 3) Describe procedure developer of study media base on Visualization of Museum Sasana Wiratama to increase Awareness of student history 4) To analyze how far the effectivity by using study of history by using study media base on Visualization of Museum Sasana Wiratama to increase Awareness of history. Research of development use method which adaptation of design development of ADDIE. Result of media effectiveness test study show good result. So that can be pulled by conclusion that usage of media study of history base on visualization of Museum effective proven Sasana Wiratama in improving achievement and awareness of History at student. Keyword: Media, Development, Visualisation, History.