bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study of Prescription Pattern and Compliance of Anti-hypertensives with the Treatment Guidelines in Aseer Region; Saudi Arabia
Authors: Siddiqua Ayesha , Alshehri Afaf , Alahmari Amal M. , Alshehri Rawan A. , Badawy Somayh S. 
Published: April 2019

Background:
A prescription study is an effective method to evaluate irrational
prescribing practice. Hypertension is one such major chronic disease. Compliance to
guidelines like the JNC-8 (Eighth Joint National Committee) and Saudi Hypertension
guidelines is highly recommended to prevent future complications.

Objective:
We conducted this study to assess prescribing pattern and their compliance
with the guidelines in the patients.

Methods:
A Retrospective cross-sectional study was carried out for 7 weeks in 2017 in
Aseer region, Abha, Saudi Arabia on 122 outpatient prescriptions which were included by
Non-probability convenience sampling technique. Data from patients aged above 18 years
with any stage of Hypertension with or without Diabetes Mellitus was collected.

Results:
It was found that Angiotensin converting enzyme inhibitors were frequently prescribed
as monotherapy in patients with Hypertension with or without Diabetes Mellitus
which is in compliance to the guidelines. Beta-blockers were most commonly used in 2
and 3 drug therapy of patients with only Hypertension which was not in accordance with
the guidelines.

Conclusion:
By this it could be concluded that the Prescription pattern of Antihypertensive
in Aseer Region was in compliance with both the guidelines to a partial extent.
Though most of the prescriptions were rational, further improvement was required.
Studies that focus on demographic data, economic status, associated conditions and complications
would give additional insights into prescribing patterns in hypertension.
Preparation of Specific Polyclonal Antibody Against the Recombinant Mutacin Produced by sfGFP Fusion Protein Technology
Authors: Al-Homsi Lamis , Al-Okla Souad , Abbady Abdul Q. 
Published: April 2019

Mutacin I, a bacteriocin produced bystreptococcus mutans, displays an antimicrobial activity against many gram positive and some gram negative bacteria. Because of its medical importance, production of this short peptide in large scale for future applications is a significant challenge. This work described the improvement of a novel system to produce the recombinant mutacin using fusion protein technology.The short peptide was expressed directly as a fusion protein with a superfolder form of the green florescent protein (sfGFP), resulting in a high yield expression of solublesfGFP-mutacin fusion protein (30 kDa) in the cytoplasm of E. coli. Mutacin was released from the fusion by enzymatic cleavage at the tobacco etch virus (TEV) protease recognition site and separated from the carriersfGFP by nickel affinity and gel filtration chromatography. An additional advantage of this fusion system was tested in the generation of mutacin-specific polyclonal antibodies. Specific anti-mutacin IgGs were affinity purified, and were able to recognize the mutacin-sfGFP fusion protein or the cleaved forms of mutacin.Even though it was efficiently produced (25 mg/L) by this method, pure mutacin was devoid of antibiotic activity. Fourier transform infrared spectroscopy (FTIR) analysis revealed the absence of thioether bonds in the purified mutacin, which are critical for final structure and function of this antibiotic. Determining whether the activity of pure mutacin could be recovered by the reformation of such structures by chemical reaction needs more investigations. The development of this system will provide large quantities of mutacin for future studies and applications as broad spectrum antibacterial peptide.
Bioinspired Smart Nanosystems in Advanced Therapeutic Applications
Authors: Singh Satya Prakash , Sirbaiya Anup Kumar , Mishra Anuradha 
Published: April 2019

Background:Nanoparticle technologies used for human administration must be designed to interact with a living host environment. The idea about bioinspired smart drug delivery carriers includes the development of biocompatible nanomaterials which can be further loaded with the drug for specific targeted drug delivery applications.Objective:Biosmart nanosystems are used for several applications in the delivery of drugs and pharmaceuticals for their therapeutic applications like biological markers, diagnostic purposes such as imaging applications and also for gene therapy. Thus, the bioinspired nanocarriers are capable of carrying biologically active molecules to the target sites. This bioinspired nanosystem constitutes of lipids, polymers and biomaterials which utilizes various responsive sensors for targeted drug delivery systems. However, external conditions such as heat, light, magnetic or electric field and ultrasounds, along with temperature, altered pH and ionic strength can affect the bioinspired smart nanosystem for drug delivery.Conclusion:The present review focuses on challenges for the development of bioinspired smart nanocarriers for the management of various disorders.
Pengaruh OJT, Prestasi Belajar, Informasi Kerja, dan Motivasi Kerja Terhadap Kesiapan Kerja Siswa SMK
Authors: Yusman Intan Yunia , Ismiyati Ismiyati , Mar’atus Sholikah Mar’atus 
Published: April 2019

Penelitian ini bertujuan untuk mengetahui adanya pengaruh on the job training (OJT), prestasi belajar, informasi tentang kerja, dan motivasi untuk kerja terhadap kesiapan kerja siswa. Populasi penelitian ini berjumlah 140 siswa dari Kompetensi Keahlian Otomatisasi dan Tata Kelola Perkantoran (OTKP) di SMK Negeri 1 Purbalingga. Sampling jenuh merupakan teknik yang digunakan dalam penelitian ini. Metode penelitian dalam penelitian ini menggunakan kuantitatif kausalitas. Metode dalam mengumpulkan data penelitian ini menggunakan angket, wawancara, dan dokumentasi. Dalam penelitian ini, menggunakan analisis data regresi berganda dan deskriptif persentase. Hasil penelitian diketahui: pertama, semua variabel bebas meliputi on the job training (OJT), prestasi belajar, informasi tentang kerja, dan motivasi untuk kerja memiliki pengaruh secara parsial dan signifikan terhadap kesiapan kerja siswa yaitu masing-masing ditunjukkan dengan nilai thitung sebesar 4.43, 4.335, 3.34, dan 2.44 lebih besar dari ttabel = 1.97769. Kedua, adanya pengaruh secara simultan antara on the job training (OJT), prestasi belajar, informasi tentang kerja, dan motivasi untuk kerja terhadap kesiapan kerja siswa yaitu ditunjukkan dengan Fhitung = 63.432 > Ftabel = 2,439246. Kata kunci: Kesiapan Kerja Siswa, On The Job Training, Prestasi Belajar, Informasi Tentang Kerja, Motivasi Untuk Kerja Abstract: Effect of OJT, Learning Achievement, Job Information, and Work Motivation on Work Readiness of Vocational Students. The aims of this study determine the effect of of on the job training (OJT), learning achievement, information about work, and motivation to work on work readiness. The population in this study is students in class XII from OTKP at SMK Negeri 1 Purbalingga as many as 140 students. This study uses saturated sampling technique. The research methods used is a quantitative method with the type of causality. Meanwhile, the data collection was done by using questionnaire, interviews, and documentation. In this study uses multiple linier regression analysis and descriptive analysis of the percentage with significance level 0.05. The result of this study is known: firstly, the variables of on the job training (OJT), learning achievement, information about work, and motivation to work have a significantly effect the work readiness, as indicated by the value of tstat 4.43, 4.335, 3.34, and 2.44 > 2.44 (tcrit.). Secondly, the variables of on the job training (OJT), learning achievement, information about work, and motivation to work have a significantly affect the work readiness as indicated by the value of Fstat 63.432 > 2.439246 (Fcrit.). Keyword: Work Readiness, On The Job Training (OJT), Learning Achievement, Information About Work, And Motivation To Work
Development of Serious Games (Equit’Game) to Address Health and Environmental Inequalities: Protocol for an App-Delivered Program to Perform a Territorial Diagnosis
Authors: Kihal Talantikite Wahida , Renou Damien , Magdelaine Arnold , Harang William , Zmirou-Navier Denis , Deguen Severine 
Published: April 2019

Background
Territorial diagnosis is a prerequisite for local actions concerning public health and for the reduction of social, environmental, and health-related inequalities. To orient local programs or initiatives targeting health inequalities, policymakers need a simulation of territorial diagnosis tools. Yet, very few platforms have been developed for the purpose of guiding public authorities as they seek to reduce these social inequalities.

Objective
This study aimed to describe the design and methods of the development process of a territorial diagnosis tool based on a serious game named Equit’Game that puts learners at the heart of the territorial diagnosis process, asking them to review the current state of health, environmental state, and socioeconomic state of their territory.

Methods
The realistic situations employed in our serious game should encourage players, in a fun and playful manner, to (1) appropriate the data of their own territory, (2) apply their methodological knowledge in a practical way, (3) reflect on the most pertinent statistical or spatial tools for their situation, and (4) ultimately, to acquire new knowledge and skills in the use of territorial diagnosis tools with a spatial dynamic. Equit’Game was deployed over the course of a week’s training and structured into 4 levels: level 1, Dataminer (identifying relevant information to respond to the question); level 2, Analyst (selecting the appropriate method of analysis); level 3, Atlas (mapping the data); and level 4, Cluster (extraction of statistical and spatial information). Equit’Game has also been designed as a sort of virtual campus, creating a fun learning environment in which each door represents a level. Users can access Equit’Game via a platform compatible with tablets, PCs, and mobile phones.

Results
In the first step, we tested our application interface designed especially for adults among a panel of local health professionals. The following are some of the most relevant points: font size and colors used, voice accompaniment in texts and messages guiding the user, clear and easy interfaces, and the change between successive game levels. In the second step, we used our application, Equit’Game, with postgraduate students from the School of Public Health (École des hautes études en santé publique). At the end of the game session, we conducted a satisfaction survey, including several items covering both the application interface and the execution of the game.

Conclusions
Equit’Game was developed to help learners with the techniques of territorial diagnosis, with the aim of creating an innovative tool for public health capable of conveying educational messages and providing a structure for training.

International Registered Report Identifier (IRRID)
PRR1-10.2196/11786
Word Embedding for the French Natural Language in Health Care: Comparative Study
Authors: Dynomant Emeric , Lelong Romain , Dahamna Badisse , Massonnaud Clément , Kerdelhué Gaétan , Grosjean Julien , Canu Stéphane , Darmoni Stefan J 
Published: April 2019

Background
Word embedding technologies, a set of language modeling and feature learning techniques in natural language processing (NLP), are now used in a wide range of applications. However, no formal evaluation and comparison have been made on the ability of each of the 3 current most famous unsupervised implementations (Word2Vec, GloVe, and FastText) to keep track of the semantic similarities existing between words, when trained on the same dataset.

Objective
The aim of this study was to compare embedding methods trained on a corpus of French health-related documents produced in a professional context. The best method will then help us develop a new semantic annotator.

Methods
Unsupervised embedding models have been trained on 641,279 documents originating from the Rouen University Hospital. These data are not structured and cover a wide range of documents produced in a clinical setting (discharge summary, procedure reports, and prescriptions). In total, 4 rated evaluation tasks were defined (cosine similarity, odd one, analogy-based operations, and human formal evaluation) and applied on each model, as well as embedding visualization.

Results
Word2Vec had the highest score on 3 out of 4 rated tasks (analogy-based operations, odd one similarity, and human validation), particularly regarding the skip-gram architecture.

Conclusions
Although this implementation had the best rate for semantic properties conservation, each model has its own qualities and defects, such as the training time, which is very short for GloVe, or morphological similarity conservation observed with FastText. Models and test sets produced by this study will be the first to be publicly available through a graphical interface to help advance the French biomedical research.
Mobile Phone Access and Preference for Technology-Assisted Aftercare Among Low-Income Caregivers of Teens Enrolled in Outpatient Substance Use Treatment: Questionnaire Study
Authors: Ryan-Pettes Stacy R , Lange Lindsay L , Magnuson Katherine I 
Published: April 2019

Background
Improvements in parenting practices can positively mediate the outcomes of treatment for adolescent substance use disorder. Given the high rates of release among adolescents (ie, 60% within three months and 85% within one year), there is a critical need for interventions focused on helping parents achieve and maintain effective parenting practices posttreatment. Yet, research suggests that engaging parents in aftercare services is difficult, partly due to systemic-structural and personal barriers. One way to increase parent use of aftercare services may be to offer mobile health interventions, given the potential for wide availability and on-demand access. However, it remains unclear whether mobile phone–based aftercare support for caregivers of substance-using teens is feasible or desired. Therefore, formative work in this area is needed.

Objective
This study aims to determine the feasibility and acceptability of mobile phone–based aftercare support in a population of caregivers with teens in treatment for substance use.

Methods
Upon enrollment in a treatment program, 103 caregivers completed a mobile phone use survey, providing information about mobile phone ownership, access, and use. Caregivers also provided a response to items assessing desire for aftercare services, in general; desire for mobile phone–based aftercare services specifically; and desire for parenting specific content as part of aftercare services. Research assistants also monitored clinic calls made to caregivers’ mobile phones to provide an objective measure of the reliability of phone service.

Results
Most participants were mothers (76.7%) and self-identified as Hispanic (73.8%). The average age was 42.60 (SD 9.28) years. A total of 94% of caregivers owned a mobile phone. Most had pay-as-you-go phone service (67%), and objective data suggest this did not impede accessibility. Older caregivers more frequently had a yearly mobile contract. Further, older caregivers and caregivers of adolescent girls had fewer disconnections. Bilingual caregivers used text messaging less often; however, caregivers of adolescent girls used text messaging more often. Although 72% of caregivers reported that aftercare was needed, 91% of caregivers endorsed a desire for mobile phone–based aftercare support in parenting areas that are targets of evidence-based treatments.

Conclusions
The results suggest that mobile phones are feasible and desired to deliver treatments that provide support to caregivers of teens discharged from substance use treatment. Consideration should be given to the age of caregivers when designing these programs. Additional research is needed to better understand mobile phone use patterns based on a child’s gender and among bilingual caregivers.
Maltrato en el pregrado de la Facultad de Medicina de la UNAM
Authors: Reyes Arellano Wulfrano Antonio , Ramírez Grycuk Ma. Teresa , Ponce de León Castañeda María Eugenia , García García Juan José 
Published: April 2019

Introducción: El maltrato al alumnado se encuentra documentado en muchas escuelas de medicina del mundo. Su presencia se manifiesta por disminución de la confianza en sí mismos, pobre desempeño académico y ser fuente de conflictos familiares y sociales. Cuando se reconoce la presencia de este fenómeno, se brinda desagravio a las personas afectadas, asociándose a una disminución de las conductas abusivas.
Método: Se llevó a cabo un estudio observacional, prospectivo, transversal y comparativo, con estudiantes del primero al cuarto año de la carrera de medicina de la Facultad de medicina de la UNAM.
Resultados: La muestra estuvo conformada por 2250 estudiantes, la mayoría fueron mujeres. No hubo diferencias estadísticamente significativas en la composición por sexo entre los cuatro años escolares. 73.5%, correspondieron a estudiantes de ciclos básicos. El maltrato fue referido por más de la cuarta parte de las y los alumnos estudiados (27%). Se observaron diferencias estadísticas en la prevalencia entre los diferentes años escolares. El maltrato por autoritarismo fue el que se presentó con mayor porcentaje, seguido en menor proporción por aquel asociado a género, al acoso sexual, y a la orientación sexual. El menos común fue el maltrato físico. Entre las razones para no reportar los hechos se encontraron minimizar su importancia, no saber qué hacer o temor a posibles represalias.
Conclusión: Se encontraron diferentes tipos de maltrato, aunque algunos no son reconocidos como tales o son tolerados. De acuerdo a los hallazgos, una misma persona habría sufrido más de uno de ellos: Falta difusión de información acerca de los mecanismos para reportar este tipo de incidentes y reconocer el seguimiento y resolución del caso.
Impacto post-innovación curricular en la percepción del ambiente educacional en estudiantes de tecnología médica
Authors: Chacón de la Cruz Tomás , Castillo Pimienta Carlos , Díaz-Véliz Gabriela 
Published: April 2019

Introducción: En la última década, la Facultad de Medicina de la Universidad de Chile ha modificado los currículos de las ocho escuelas de la salud que la componen, con el fin de orientar el proceso educativo de los estudiantes, en función de sus perfiles profesionales.Objetivo: Determinar el impacto de la innovación curricular en la percepción del ambiente educacional de los estudiantes de segundo año de la Escuela de Tecnología Médica de la Facultad de Medicina.
Método: Estudio transversal realizado en cuatro cohortes sucesivas (N = 308), dos con currículo antiguo (años 2012 y 2013) y dos con currículo innovado (años 2014 y 2015). A todos los estudiantes se les aplicó el cuestionario DREEM. Este instrumento fue diseñado para medir la percepción del ambiente educacional y consta de 50 ítems, divididos en 5 subescalas: percepción de la enseñanza, de los profesores y del ambiente de aprendizaje, autopercepción académica y social.
Resultados: El puntaje promedio total aumentó significativamente en los dos años post-innovación (2012:116.2; 2013:117.6; 2014:131.1; 2015:133.3). Además, en las cohortes 2014 y 2015, aumentó significativamente el porcentaje de estudiantes que consideraron el ambiente educacional como excelente (2012:6.6%; 2013:7.5%; 2014:20.8%; 2015:23.7%). En dos de las cinco subescalas del cuestionario DREEM, percepción de la enseñanza y percepción del ambiente de aprendizaje, aumentó significativamente la percepción positiva en los estudiantes que cursaban el currículo innovado. En el resto de las subescalas no se observaron diferencias significativas entre las cuatro cohortes.
Conclusiones: De acuerdo con la opinión de los estudiantes, el proceso de innovación curricular en la Escuela de Tecnología Médica corrigió satisfactoriamente algunos aspectos deficitarios del currículum antiguo. El cuestionario DREEM entregó indicaciones acerca de las prioridades al momento de reformar el currículo.
INFLUENCE OF USE OF MIND MAPPING METHOD BY TEACHERS ON TEACHING PREPARATION IN BASIC SCHOOL IN SUBJECT OF MATERIALS TEACHING EYES LESSON SCIENCE NATURAL SCIENCE (IPA)
Authors: Hermansyah Dadang , Witarsa Ramdhan 
Published: April 2019

In terms of time, Mind Mapping can streamline the use of time in studying an information. This is mainly because this method can present a comprehensive picture of a thing in a short time. In other words, Mind Mapping is able to cut learning time by changing the pattern of linear recording into effective recording and at the same time directly understood by the individual. So is the preparation of teachers. Teaching preparation is a special tip in the successful delivery of a subject matter. One of the subjects in Elementary School (ES) is a Natural Science that in fact many proofs between theory and practice. Therefore, the Mind Mapping method in preparation for teaching is one of the special tips for the delivery of the material in its entirety. The more mature the preparation of a teacher in planning the lesson, the better prepared the teacher teaches. With Mind Mapping, the teacher must have tried to think about the things involved with the lesson to be conveyed, such as the tool of the demonstration, how to estimate the condition of the learning condition if using the props, how to use the props, or whether the learner should try the props We make / we serve. With Mind Mapping, teachers are ready to teach with all their abilities accompanied by learning tools that are prepared. Keywords: Mind Mapping, Preparation, Teaching.
MODELOS FAMILIARES DENTRO DEL ORDEN JURÍDICO MEXICANO: NATURALEZA, PRINCIPIOS Y LA NECESIDAD DE SU ACTUALIZACIÓN
Authors: Velázquez Santiago J. Chablé , Plancarte Alejandra Navez , Notario José Antonio Morales 
Published: April 2019

En México, la familia es considerada un ente sujeto de derechos humanos, partiendo esto de la composición familiar; misma que de acuerdo a la legislación vigente sufre severas vulneraciones a sus prerrogativas, ya que en la actualidad se aleja de los modelos “tradicionales”, dándose de manera tácita algunos tipos de familia que los ordenamientos jurídicos no contemplan, derivado de la creencia que existe sobre que el matrimonio significa familia, siendo esta una aseveración jurídicamente sin sustento, como lo son también las fobias que retrasan la actualización del marco jurídico mexicano.
En este análisis se engloban aspectos de las tres corrientes clásicas de la filosofía jurídica, es decir, del iusnaturalismo, del iuspositivismo y del realismo jurídico. Sin duda los modelos de composición familiar han sido objeto de estudio desde tiempos inmemorables, creándose con el paso del tiempo conceptos como la familia nuclear, la familia extendida, la familiar natural, la familia reconstruida, entre otras. La ciencia jurídica no ha sido ajena a estos estudios, es por ello que, tanto en la doctrina como en los cuerpos legales, la familia juega un rol primordial, reconociéndosele ese carácter de base de la sociedad —concepción que es compartida con la sociología—, y que únicamente es superado por la persona cuando a ésta se le reconoce ese carácter de individualidad.