bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between ER and HER2neu status with various sonographic findings in breast cancer
Authors: Abo Dega Farah 
Published: November 2024

Diagnostic ultrasonography is often used as a radiological modality for assessing clinically or radiologically suspected mammary lesions based on certain radiological criteria. This study was conducted to investigate an association between breast sonographic findings and biological markers (ER and HER2\NEU). The study enrolled 100 histological sample of invasive mammary carcinoma diagnosed by core needle biopsy, 52% from the right breast and 48 % from the left one , age range of patient was from 28 to 80 years with a mean age was 53 years. 64 % were estrogen receptor positive, 54% were HER2\NEU positive. There is a significant statistical correlation between ER and HER2\NEU positivity with the simultaneous presence of axillery lymph node metastasis. While there is a non statistical relashioship between ER and HER2\NEU positivity with various sonographic findings in invasive mammary carcinoma. Thus, breast ultrasound based findings are of no help to predict ER and HER2 status of invasive mammary carcinoma.
On safety issues at water transport facilities
Authors: Sotnikova YUliya Vasil'evna 
Published: November 2024

The subject of the study is safety at water bodies. Ensuring safety at water bodies requires a systematic approach that includes training and prevention. Informing the public about potential risks and rules of behavior on the water plays a key role in reducing the number of incidents and saves lives. Regular educational campaigns and awareness-raising activities allow to form a responsible attitude towards one's own health and safety. Coordination of the efforts of the state, business and public organizations creates the necessary conditions for the implementation of comprehensive programs aimed at protecting the population on water bodies. This approach minimizes risks, ensures readiness to respond in emergency situations and contributes to improving overall safety on the water. When writing the article, we used statistical data from the Ministry of Emergency Situations of Russia, rules and recommendations for ensuring water safety, rules of conduct in extreme situations on the water, as well as regulatory documentation establishing legal instruments for regulating safety of the water transport. One of the key aspects of this study is to identify existing gaps in the legislative framework governing safety of the water transport. Despite the existence of a number of regulatory legal acts, many aspects remain insufficiently regulated. The analysis of existing gaps in the legal regulation requires a comprehensive approach to the study of public relations in this area. Not only government agencies and regulatory organizations play an important role in this process, but also citizens' associations, professional associations and non-governmental organizations. The conclusion of this study highlights the need to review and improve the current rules and regulations governing safety of the water transport. It is obvious that a comprehensive understanding and interaction of all stakeholders will create the basis for the development of a more secure and reliable system. Legislation should take into account both the current realities of the use of water resources and the prospects for their change in the future.
Platelets’ Functionality in Hemostasis, Inflammation, and Immune Response to Infections
Authors: Ayodele Opeyemi Oluwayemisi , Olujimi Folakemi Omolara , Oyerinde Olawunmi Rashidat 
Published: November 2024

Platelets play a central role in hemostasis and are increasingly recognized for their critical functions in immune responses and inflammation. This review explores the mechanisms by which platelets contribute to these processes, from their involvement in clot formation and wound healing to their emerging role in modulating immune cell activity during infections. The interaction between platelets and the inflammatory cascade creates a complex inflammation-hemostasis loop, with implications for both acute and chronic disease states. Platelets aggregate at the site of tissue damage, and adhere to the white blood cells, with subsequent release of cytokines and chemokines which are required for targeting lymphocytes, monocytes, and neutrophils to promote inflammation. Similarly, platelets engulf microbes and affect the prognosis of bacterial and viral infections. Recent advances in understanding platelet function during bacterial and viral infections are discussed, with a focus on the therapeutic potential of targeting platelet-mediated pathways in various pathological conditions.
Exploring Photobiomodulation Therapy for Long COVID Xerostomia: A Randomized Controlled Pilot Trial
Authors: Oliveira Susyane Vieira , Amorim Ana Cristina Ferreira Garcia , Lima Talita Oliveira , Silva Gabriela Laís da , Oliveira Juliana Regina de , Rodrigues Maria Fernanda Setúbal Destro , Cecatto Rebeca Boltes 
Published: November 2024

Aims: To investigate the effects of a photobiomodulation protocol in the treatment of long COVID-19 xerostomia
Study Design: This is a single-center, randomized, controlled, double-blind pilot clinical trial.
Methodology: 10 patients with long COVID-19 xerostomia are randomized into two groups. The participants receive a standard xerostomia treatment and also a low-intensity photobiomodulation therapy or placebo photobiomodulation therapy on the cutaneous topography of the salivary glands (a RED LED cluster, 2 J/cm2, 108 J per session, twice a week for six weeks). The outcomes measured using the Oral Health Impact Profile (OHIP-14), Xerostomia Inventory (XI) Scale, Brazilian version of SF-36 Quality of Life Scale, Brazilian Version of Functional Independence Measure (FIM), sialometry and salivary pH before and after the therapeutic period of six weeks of intervention.
Results: there were no significant differences between the photobiomodulation and placebo groups in the baseline or post-intervention moments for evaluated outcomes. In the individual analysis of the OHIP-14 and XI items, a difference was observed in the values of the PBM group comparing the pre-intervention baseline moment with the post-intervention PBM moment, not founded in the placebo group. No adverse effects are reported.
Conclusion: This PBM protocol was not superior to placebo in treating long COVID xerostomia for the evaluated outcomes. This study has limitations such as the small sample size and unblinding issues, which may have leading to a lack of significant results for primary outcomes in both the PBM and placebo groups. PBM irradiation of the salivary glands could be studied as a future approach to improving salivary production in patients with xerostomia due to long COVID.
RELAÇÕES INTERCULTURAIS NA PESQUISA EM COMUNICAÇÃO: UMA ABORDAGEM DECOLONIAL
Authors: Panis Kaseker Mônica , Xavier Vessoni Dominique 
Published: November 2024

O artigo busca problematizar a proposta epistemológica decolonial e as práticas meto dológicas do investigador não indígena na pesquisa em comunicação envolvendo sujeitos comunicacionais indígenas, em especial ao analisar produções indígenas nas etnomídias. Propõe-se discutir teoricamente o potencial da cartografia sentimental como trajeto metodológico para uma investigação que se pretende decolonial, encontrando aproximações com a perspectiva do corazonar e sentipensar. Uma das questões mais latentes é a preocupação em neutralizar a perspectiva eurocêntrica e as metodologias extrativistas. Neste sentido, a pesquisa decolonial se torna um encontro entre sujeitos numa ecologia de saberes, uma experiência vivida com os corpos, cujas afetações desconstroem e constroem conhecimentos outros.
LOS MEDIOS SON TALES POR SU INTERACCIÓN CON OTROS MEDIOS
Authors: Aruguete Natalia 
Published: November 2024

Carlos Scolari es un investigador argentino de reconocida trayectoria, por su experticia en el estudio de los medios digitales, la semiótica de las interfaces y los procesos de interacción y ecología de la comunicación. Actualmente es Catedrático de Teoría y Análisis de la Comunicación Digital Interactiva del Departament de Comunicació de la Universitat Pompeu Fabra, en Barcelona, España.
A comienzos del año 2024 publicó su último libro Sobre la evolución de los medios (ediciones Ampersand), donde analiza los procesos de transformación de los medios desde una mirada convergente de distintos enfoques que le permita explicar tal evolución a partir de sus interconexiones, similitudes y diferencias, en un mundo que “muta más rápido que los conceptos y las teorías”.
“Ningún medio adquiere su significado o existencia por sí solo, sino sólo en constante interacción con otros medios”. Con esta frase de McLuhan, el investigador argentino expresa, en parte, el espíritu de su este Sobre la evolución de los medios. En esta entrevista, Scolari analiza algunos de los conceptos trabajados en un recorrido extraordinario sobre la relación coevolutiva entre los medios, pensada como un vector que modela el cambio mediático a partir de un ida y vuelta que se prolonga en el tiempo.
Pensar las transformaciones intermediáticas a partir de movimientos de convergencia que conviven con otros de divergencia y con dinámicas de competencia y cooperación, le permite entender los procesos de adaptación de las viejas y las nuevas formas mediáticas así como sus estrategias de emergencia y supervivencia en un escenario cada vez más dinámico y, en ocasiones, impredecible.
Autor de Hipermediaciones (2008), La guerra de las plataformas (2022) y Narrativas transmedia (2013) -por mencionar solo algunas de sus publicaciones- Scolari advierte sobre la inconveniente de extender un certificado de defunción de ciertos medios frente a la emergencia de otros, dado que siempre pueden sobrevivir -en su totalidad o algunos de sus elementos- en nuevas formas mediáticas.
Umsetzung der DAC8-Richtlinie: Reportingpflichten für Bitcoin, Ether und Co. im Rahmen des internationalen Informationsaustauschs
Authors: Schmitt Lukas , Acker Martin 
Published: November 2024

Zusammenfassung
Der Beitrag stellt die Hintergründe der Entwicklung der DAC8- Richtlinie dar, betrachtet sie im Kontext der weltweiten Bemühungen um einen automatischen Informationsaustausch zwischen Steuerbehörden und geht auf die wesentlichen Regelungskomplexe ein. Hierzu werden der Anwendungsbereich, der Umfang der Meldepflichten und die hierfür relevanten Fristen beschrieben und im Hinblick auf den praktischen Anwendungsfall eingeordnet.
EU-AHiRL: Der Schutz des Berufsgeheimnisses im Steuerverfahren
Authors: Sendke Thomas 
Published: November 2024

Zusammenfassung
Das Steuerverfahrensrecht nimmt in der Rechtsprechung des EuGH mittlerweile eine feste Rolle ein. Hierfür gibt es im Wesentlichen zwei Gründe. Zum einen ist die EU-Amtshilferichtlinie in den vergangenen Jahren kontinuierlich erweitert worden. Dabei regelt das Sekundärrecht längst nicht mehr nur die Zusammenarbeit zwischen den Finanzverwaltungen, sondern erzwingt auch Grundrechtseingriffe durch die mitgliedstaatlichen Gesetzgeber und Steuerbehörden. In den Fokus geraten dabei auch Rechtsanwälte und Steuerberater, die besonderen Verschwiegenheitspflichten unterliegen. Zum anderen haben die Unionsgrundrechte insbesondere im Steuerverfahrensrecht an Bedeutung gewonnen. Der EuGH wird seiner Funktion als Grundrechtsgericht zunehmend auch im Steuerrecht gerecht. Exemplarisch hierfür stehen zwei aktuelle Entscheidungen des Gerichtshofs zum Informationsaustausch auf Ersuchen und zur Anzeigepflicht für grenzüberschreitende Steuergestaltungen, die im Folgenden genauer beleuchtet werden sollen.
OECD-Verrechnungspreisrichtlinien: Verlustunternehmen in Benchmarkstudien – Besprechung des Urteils v. 16.7.2024 des Obersten italienischen Gerichtshofs
Authors: Heidecke Björn , Christen Anna-Katharina , Pelosi Daniele 
Published: November 2024

Zusammenfassung
Die Einbeziehung von Verlustunternehmen in Benchmarkstudien ist ein zentrales Thema in der Verrechnungspreispraxis. Der vorliegende Beitrag untersucht die Notwendigkeit einer differenzierten Betrachtung solcher Unternehmen basierend auf den OECD-Verrechnungspreisleitlinien. Ein pauschaler Ausschluss von Verlustunternehmen ist nicht sachgerecht; stattdessen sollte die Vergleichbarkeit im Einzelfall geprüft werden. Ein aktuelles Urteil des Obersten italienischen Gerichtshofs bestätigt diese Sichtweise und unterstreicht die Relevanz einer detaillierten Analyse. Der Artikel bespricht das Urteil und gibt eine Empfehlung zum Umgang mit Verlustunternehmen bei der Erstellung von Benchmarkstudien aus deutscher Verrechnungspreissicht.
Real‐time use of audio‐biofeedback can improve postural sway in patients with degenerative ataxia
Authors: Fleszar Zofia , Mellone Sabato , Giese Martin , Tacconi Carlo , Becker Clemens , Schöls Ludger , Synofzik Matthis , Ilg Winfried 
Published: November 2018

AbstractObjectiveCerebellar ataxia essentially includes deficient postural control. It remains unclear whether augmented sensory information might help cerebellar patients, as the cerebellum underlies processing of various sensory modalities for postural control. Here, we hypothesized that patients with cerebellar degeneration can still exploit audio‐biofeedback (ABF) of trunk acceleration as a real‐time assistive signal to compensate for deficient postural control.MethodsEffects on postural sway during stance were assessed in an ABF intervention group versus a no‐ABF disease control group (23 vs. 17 cerebellar patients) in a clinico‐experimental study. A single‐session ABF paradigm of standing plus short exergaming under ABF was applied. Postural sway with eyes open and eyes closed was quantified prior to ABF, under ABF, and post ABF.ResultsPostural sway in the eyes closed condition was significantly reduced under ABF. Both benefit of ABF and benefit of vision correlated with the extent of postural sway at baseline, and both types of sensory benefits correlated with each other. Patients with strongest postural sway exhibited reduced postural sway also with eyes open, thus benefitting from both vision and ABF. No changes were observed in the no‐ABF control group.InterpretationOur findings provide proof‐of‐principle evidence that subjects with cerebellar degeneration are still able to integrate additional sensory modalities to compensate for deficient postural control: They can use auditory cues functionally similar to vision in the absence of vision, and additive to vision in the presence of vision (in case of pronounced postural sway). These findings might inform future assistive strategies for cerebellar ataxia.
Superficial‐Layer‐Enhanced Raman Scattering (SLERS) for Depth Detection of Noncontact Molecules
Authors: Qiao Xuezhi , Xue Zhenjie , Liu Lu , Liu Keyan , Wang Tie 
Published: November 2018

AbstractAlthough the strength of Raman signals can be increased by many orders of magnitude on noble metal nanoparticles, this enhancement is confined to an extremely short distance from the Raman‐active surface. The key to the development of Raman spectroscopy for applications in diagnosis and detection of cancer and inflammatory diseases, and in pharmacology, relies on the capability of detecting analytes that are noninteractive with Raman‐active surfaces. Here, a new Raman enhancement system is constructed, superficial‐layer‐enhanced Raman scattering (SLERS), by covering elongated tetrahexahedral gold nanoparticle arrays with a superficial perovskite (CH3NH3PbBr3) film. Plasmonic decay is depressed along the vertical direction away from the noble metal surface and the penetration depth is increased in the perovskite media. The vertical penetration of SLERS is verified by the spatial distribution of the analytes via Raman imaging in layer‐scanning mode.
Self‐Assembly of a Monochromophore‐Based Polymer Enables Unprecedented Ratiometric Tracing of Hypoxia
Authors: Wang Shuwen , Gu Kaizhi , Guo Zhiqian , Yan Chenxu , Yang Tingyuan , Chen Zhuo , Tian He , Zhu Wei‐Hong 
Published: November 2018

AbstractThe accuracy of traditional bischromophore‐based ratiometric probes is always compromised by undesirable energy/charge transferring interactions between the internal reference moiety and the sensing chromophore. In this regard, ratiometric sensing with a monochromophore system is highly desirable. Herein, an unprecedented monochromophore‐based ratiometric probe, which consists of a hydrophilic backbone poly(N‐vinylpyrrolidone) (PVP) and single chromophore of platinum(II) tetraphenylporphyrin (Pt‐TPP) is reported. Combination of the specific assembled clustering‐triggered fluorescent emission (oxygen‐insensitive) with the original Pt‐TPP phosphorescence (oxygen‐sensitive) enables successful construction of a monochromophore‐based ratiometric nanosensor for directly tracing hypoxia in vivo, along with the preferable facilitation of enhanced permeation and retention effect and long excitation wavelength. The unique ratiometric signals enable the direct observation from normoxic to hypoxic environment in both living A549 cells and a tumor‐bearing mice model, providing a significant paradigm of a monochromophore‐based dual‐emissive system with the specific assembled cluster emission. The work satisfactorily demonstrates a valuable strategy for designing monochromophore‐based dual‐emissive materials, and validates its utility for in vivo ratiometric biological sensing without the common energy/charge interference in bischromophore‐based system.
Potassium Persulfate‐Mediated Thiocyanation of 2H‐Indazole under Iron‐Catalysis
Authors: Dey Amrita , Hajra Alakananda 
Published: November 2018

AbstractPotassium persulfate‐mediated thiocyanation of 2H‐indazoles has been developed using ammonium thiocyanate as thiocyanating agent under iron‐catalysis at room temperature. 2‐Aryl‐3‐thiocyanato‐2H‐indazoles are synthesized in good yields with a broad substrates scope. This methodology is also applicable for the selenocyanation of 2H‐indazoles. The mechanistic study suggests the reaction probably proceeds through a radical pathway.magnified image
Hydrodynamic Impedance Correction for Reduced‐Order Modeling of Spermatozoa‐Like Soft Micro‐Robots
Authors: Tabak Ahmet Fatih 
Published: November 2018

AbstractHydrodynamic interactions play a key role in the swimming behavior and power consumption of bio‐inspired and biomimetic micro‐swimmers, cybernetic or artificial alike. Bio‐inspired robotic micro‐swimmers require fast and reliable numerical models for robust control in order to carry out demanding therapeutic tasks as envisaged for more than 60 years. The fastest known numerical model, the resistive force theory (RFT), incorporates local viscous force coefficients with the local velocity of slender bodies in order to find the resisting hydrodynamic forces, however, omitting the induced far‐field. As a result, the power requirement cannot be predicted accurately. The question of predicting and supplying the necessary power is one of the obstacles impeding the micro‐robotic efforts. In this study, a novel strategy is proposed to improve the RFT‐based analysis, particularly for spermatozoa and spermatozoa‐inspired micro‐swimmers with elastic slender tails, in order to present a practical solution to the problem. The postulated analytical improvement and the associated correction coefficients are based on hydrodynamic impedance analysis of the time‐dependent solution of three‐dimensional (3D) Navier–Stokes equations incorporated with deforming mesh and subject to conservation of mass.
Strong Responsivity Enhancement of Quantum Dot‐in‐a‐Well Infrared Photodetectors Using Plasmonic Structures
Authors: Fowler Clayton , Kim Jun Oh , Lee Sang Jun , Urbas Augustine , Ku Zahyun , Zhou Jiangfeng 
Published: November 2018

AbstractDetector responsivity enhancement from integrating optimized plasmonic structure layers into quantum dot‐in‐a‐well photodetectors is investigated by a finite integration technique‐based simulation. It is found that by including a 0.1 µm thick gold hole‐array layer onto a backside illuminated photodetector, the peak detector responsivity is enhanced by nearly a factor of 8. A 0.2 µm thick gold disk‐array layer improves the peak responsivity by around 15 instead. The calculated enhancement factors show a good agreement with experimental data by Gu et al.[1] and Lee et al.[2] Simulation method and analytical analysis accomplished in this paper provide a generalized approach to design optimal plasmonic structures integrated to various infrared detecting device configurations.
Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme‐Catalyzed Cascade Reaction
Authors: Gao Shanshan , Lin Han , Zhang Haixian , Yao Heliang , Chen Yu , Shi Jianlin 
Published: November 2018

AbstractEmerging nanocatalytic tumor therapies based on nontoxic but catalytically active inorganic nanoparticles (NPs) for intratumoral production of high‐toxic reactive oxygen species have inspired great research interest in the scientific community. Nanozymes exhibiting natural enzyme‐mimicking catalytic activities have been extensively explored in biomedicine, mostly in biomolecular detection, yet much fewer researches are available on specific nanocatalytic tumor therapy. This study reports on the construction of an efficient biomimetic dual inorganic nanozyme‐based nanoplatform, which triggers cascade catalytic reactions for tumor microenvironment responsive nanocatalytic tumor therapy based on ultrasmall Au and Fe3O4 NPs coloaded dendritic mesoporous silica NPs. Au NPs as the unique glucose oxidase‐mimic nanozyme specifically catalyze β‐D‐glucose oxidation into gluconic acid and H2O2, while the as produced H2O2 is subsequently catalyzed by the peroxidase‐mimic Fe3O4 NPs to liberate high‐toxic hydroxyl radicals for inducing tumor‐cell death by the typical Fenton‐based catalytic reaction. Extensive in vitro and in vivo evaluations have demonstrated high nanocatalytic‐therapeutic efficacy with a desirable tumor‐suppression rate (69.08%) based on these biocompatible composite nanocatalysts. Therefore, this work paves a way for nanocatalytic tumor therapy by rationally designing inorganic nanozymes with multienzymatic activities for achieving high therapeutic efficacy and excellent biosafety simultaneously.
Endoscopic Evaluation of the Eustachian Tube: assessment of a novel tool for grading Eustachian tube inflammation
Authors: McCoul Edward D. , Mayer Scott I. , Tabaee Abtin , Bedrosian Jeffrey C. , Marino Michael J. 
Published: November 2018

BackgroundSigns of inflammation are commonly encountered during endoscopic examination of the Eustachian tube (ET) region. The clinical applicability of these findings may be enhanced by use of a standardized assessment score.MethodsDigital video recordings were obtained of 50 nasal endoscopy examinations of the nasopharyngeal portion of the ET. Four fellowship‐trained rhinologists independently reviewed the videos with regard to specific physical findings: edema of the ET torus, erythema of the ET torus, exudate at the ET orifice, and presence of tubal tonsil. Scoring of this Endoscopic Evaluation of the Eustachian Tube (3ET) was reported using both 2‐point and 3‐point scales. Each reviewer repeated the scoring at a 10‐day interval. Interrater and intrarater agreement were calculated for each item and the total scores.ResultsInterrater and intrarater agreement were greater for the 3‐point scale than the 2‐point scale. Interrater agreement for overall instrument using the 3‐point scale was in the “acceptable” range for Krippendorff's alpha on both the first trial (0.6922) and second trial (0.7238). Intrarater agreement was generally “excellent” for individual items as well as the overall instrument.ConclusionThe 3ET comprising these 4 physical findings has acceptable interrater and intrarater reliability, and may be applied to future clinical studies of ET function and disease.