bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic Amplification of Oxidative Stress–Mediated Antitumor Activity via Liposomal Dichloroacetic Acid and MOF‐Fe2+
Authors: Sun Lei , Xu Yurui , Gao Ya , Huang Xinyu , Feng Shujun , Chen Jianmei , Wang Xuekun , Guo Leilei , Li Meng , Meng Xia , Zhang Jikang , Ge Junliang , An Xueying , Ding Dang , Luo Yadong , Zhang Yu , Jiang Qing , Ning Xinghai 
Published: May 2019

AbstractCancer cells are susceptible to oxidative stress; therefore, selective elevation of intracellular reactive oxygen species (ROS) is considered as an effective antitumor treatment. Here, a liposomal formulation of dichloroacetic acid (DCA) and metal–organic framework (MOF)‐Fe2+ (MD@Lip) has been developed, which can efficiently stimulate ROS‐mediated cancer cell apoptosis in vitro and in vivo. MD@Lip can not only improve aqueous solubility of octahedral MOF‐Fe2+, but also generate an acidic microenvironment to activate a MOF‐Fe2+‐based Fenton reaction. Importantly, MD@Lip promotes DCA‐mediated mitochondrial aerobic oxidation to increase intracellular hydrogen peroxide (H2O2), which can be consequently converted to highly cytotoxic hydroxyl radicals (•OH) via MOF‐Fe2+, leading to amplification of cancer cell apoptosis. Particularly, MD@Lip can selectively accumulate in tumors, and efficiently inhibit tumor growth with minimal systemic adverse effects. Therefore, liposome‐based combination therapy of DCA and MOF‐Fe2+ provides a promising oxidative stress–associated antitumor strategy for the management of malignant tumors.
Rational Construction of 3D‐Networked Carbon Nanowalls/Diamond Supporting CuO Architecture for High‐Performance Electrochemical Biosensors
Authors: Zhai Zhaofeng , Leng Bing , Yang Nianjun , Yang Bing , Liu Lusheng , Huang Nan , Jiang Xin 
Published: May 2019

AbstractTremendous demands for highly sensitive and selective nonenzymatic electrochemical biosensors have motivated intensive research on advanced electrode materials with high electrocatalytic activity. Herein, the 3D‐networked CuO@carbon nanowalls/diamond (C/D) architecture is rationally designed, and it demonstrates wide linear range (0.5 × 10−6–4 × 10−3 m), high sensitivity (1650 µA cm−2 mm−1), and low detection limit (0.5 × 10−6 m), together with high selectivity, great long‐term stability, and good reproducibility in glucose determination. The outstanding performance of the CuO@C/D electrode can be ascribed to the synergistic effect coming from high‐electrocatalytic‐activity CuO nanoparticles and 3D‐networked conductive C/D film. The C/D film is composed of carbon nanowalls and diamond nanoplatelets; and owing to the large surface area, accessible open surfaces, and high electrical conduction, it works as an excellent transducer, greatly accelerating the mass‐ and charge‐transport kinetics of electrocatalytic reaction on the CuO biorecognition element. Besides, the vertical aligned diamond nanoplatelet scaffolds could improve structural and mechanical stability of the designed electrode in long‐term performance. The excellent CuO@C/D electrode promises potential application in practical glucose detection, and the strategy proposed here can also be extended to construct other biorecognition elements on the 3D‐networked conductive C/D transducer for various high‐performance nonenzymatic electrochemical biosensors.
Nitrogen‐Doped Porous Carbon Supported Nonprecious Metal Single‐Atom Electrocatalysts: from Synthesis to Application
Authors: Guo Jiaojiao , Huo Juanjuan , Liu Yan , Wu Wenjian , Wang Yong , Wu Minghong , Liu Hao , Wang Guoxiu 
Published: May 2019

AbstractNonprecious metal single‐atom materials have attracted extensive attention in the field of electrocatalysis due to their low cost, high reactivity, high selectivity, and high atomic utilization. However, the high surface energy of a single atom causes agglomeration during preparation and catalytic measurement, resulting in damage to the catalytic sites. The strong interaction between substrate and monoatoms is the key factor to prevent the aggregation of individual metal atoms, and the geometry and electronic structure of the catalysts can be adjusted to optimize the catalytic activity. Due to the hierarchically pores, high specific surface area, and defect effect, nitrogen‐doped porous carbon (NPC) has been widely studied as an ideal nonprecious metal single‐atom support, which synergistically enhance the electrocatalytic performance toward oxygen reduction reaction, oxygen evolution reaction, hydrogen evolution reaction, carbon dioxide reduction reaction, and nitrogen reduction reaction with non‐noble metal single atoms. This review summarizes the controllable synthesis, characterization, theoretical calculation, and application of M (M = Co, Fe, Ni, Cu, Zn, Mo, etc.) single atoms on nitrogen‐doped porous carbon. Finally, the future development and challenges of nitrogen‐doped porous carbon supported nonprecious metal single‐atom electrocatalysts for practical commercialization are concluded.
Polyanions Enhance Conversion Reactions for Lithium/Sodium‐Ion Batteries: The Case of SbVO4 Nanoparticles on Reduced Graphene Oxide
Authors: Pan Jun , Zhang Yuchen , Li Lili , Cheng Zhenjie , Li Yanlu , Yang Xianfeng , Yang Jian , Qian Yitai 
Published: May 2019

AbstractAnode materials based on redox alloying/dealloying reactions are regarded as one of the promising electrodes in Li/Na‐ion batteries. However, the enormous volume change upon cycling induces the giant structure strain, particle pulverization and then capacity decay. Here, vanadates are proposed to mitigate this concern for alloy‐type anode materials, using SbVO4 as an example. As indicated by density function theory and in situ/ex situ techniques, VO43− enhances the conversion reaction between Sb3+ and Sb, buffers the structure change induced by alloying/dealloying reactions of Sb and exhibits the electrochemical activity to Li ions. These results make SbVO4 superior to Sb, Sb2O3 and SbPO4 in the electrochemical performances, which applies both to lithium‐ion batteries and to sodium‐ion batteries. Then, the structure design and carbon composite are achieved by depositing monodispersed SbVO4 nanocrystals on reduced graphene oxides via a simple solvothermal reaction. This composite shows a good cycling stability and a high rate capability, especially in sodium‐ion batteries (73.6% after 1500 cycles at 1 A g−1, or 252 mAh g−1 at 10 A g−1). These results open the door for other alloy‐type anode materials to improve the performances.
Nitrate residual as a key parameter to efficiently control partial denitrification coupling with anammox
Authors: Le Tri , Peng Bo , Su Chunyang , Massoudieh Arash , Torrents Alba , Al‐Omari Ahmed , Murthy Sudhir , Wett Bernhard , Chandran Kartik , deBarbadillo Christine , Bott Charles , De Clippeleir Haydée 
Published: May 2019

AbstractDespite the increased research efforts, full‐scale implementation of shortcut nitrogen removal strategies has been challenged by the lack of consistent nitrite‐oxidizing bacteria out‐selection. This paper proposes an alternative path using partial denitrification (PdN) selection coupled with anaerobic ammonium‐oxidizing bacteria (AnAOB). A nitrate residual concentration (>2 mg N/L) was identified as the crucial factor for metabolic PdN selection using acetate as a carbon source, unlike the COD/N ratio which was often suggested. Therefore, a novel and simple acetate dosing control strategy based on maintaining a nitrate concentration was tested in the absence and presence of AnAOB, achieving PdN efficiencies above 80%. The metabolic‐based PdN selection allowed for flexibility to move between PdN and full denitrification when required to meet effluent nitrate levels. Due to the independence of this strategy on species selection and management of nitrite competition, this novel approach will guarantee nitrite availability for AnAOB under mainstream conditions unlike shortcut nitrogen removal approaches based on NOB out‐selection. Overall, a COD addition of only 2.2 g COD/g TIN removed was needed for the PdN‐AnAOB concept showing its potential for significant savings in external carbon source needs to meet low TIN effluent concentrations making this concept a competitive alternative.Practitioner points

Nitrate residual is the key control parameter for partial denitrification selection.

Metabolic selection allowed for flexibility of moving from partial to full denitrification.

2.2 g COD/g TIN removed was needed for partial denitrification‐anammox process.
Environmental factors driving the dominance of the harmful bloom‐forming cyanobacteria Microcystis and Aphanocapsa in a tropical water supply reservoir
Authors: de J. Magalhães Aline A. , da Luz Lafayette D. , de Aguiar Junior Terencio R. 
Published: May 2019

AbstractHarmful cyanobacterial blooms in reservoirs have become a serious global issue for environmental health. However, dominance among different toxic cyanobacteria genera remains poorly understood, especially in tropical areas. We evaluated the influence of environmental factors, including total phosphorus, dissolved aluminum, water level, and precipitation on the change of the dominant genus from Microcystis to Aphanocapsa, in a hypereutrophic tropical reservoir, using 443 water samples over six years of field monitoring by applying generalized linear models (GLM). The results pointed out the prevalence of longer hydrologic retention time leading to enhanced water stability, and nutrients’ accumulation into the hypolimnetic zones of the reservoir may have favored the ecophysiological advantages for the picocyanobacteria Aphanocapsa, which reached densities greater than 1 million/ml. In addition, this article also suggests that physical–chemical remediation methods applied for immobilizing phosphorus in the sediments of the reservoir may be low effective in limiting cyanobacterial growth. These findings are not only meaningful to the understanding of the dynamics of cyanobacterial genera but also to improve the management of eutrophic reservoirs in tropical regions.Practitioner points

We assessed cyanobacterial dominance changes based on 6‐year field monitoring.

First article addressing the dominance of Aphanocapsa spp. in a tropical reservoir.

Species of Aphanocapsa responded better to hydrological changes in the reservoir.

The use of remediators was accompanied by an increase in cyanobacteria biomass.
Corporate-Level Communities at Ericsson: Parallel Organizational Structure for Fostering Alignment for Autonomy
Authors: Šmite Darja , Moe Nils Brede , Wigander Jonas , Esser Hendrik 
Published: May 2019

AbstractOrganizational management traditionally has taken care of all the important strategy, structure, and work-design decisions, as well as most of the ongoing decisions about work procedures. In large-scale corporations with many geographically distributed sites and high divisional detachment, such strategies are yet doomed to result in implementing irrelevant work methods and procedures that conflict with the local interests. As Tayloristic habits are disappearing, organizations willingly or unwillingly change their decision-making approaches to enable more participation and influence from the performers. These trends are associated with the rise of participation-based parallel structures, such as quality circles, task forces or communities of practice. In this paper, we present our findings from studying corporate-level communities by the means of a multi-case study at Ericsson. We found that the main hindrances are related to the limited decision-making authority of parallel structure, member selection and achieving representation across the organizational units. Our results suggest that parallel structures highly depend on the authority of the members within their local communities, and their ability to not only channel the dialog between the units they represent and the community, but also enable the active engagement of the unit in the community studies. As such, we believe that special attention shall be put on the ambassador role of the community members.
A Taxonomy of Software Engineering Challenges for Machine Learning Systems: An Empirical Investigation
Authors: Lwakatare Lucy Ellen , Raj Aiswarya , Bosch Jan , Olsson Helena Holmström , Crnkovic Ivica 
Published: May 2019

AbstractArtificial intelligence enabled systems have been an inevitable part of everyday life. However, efficient software engineering principles and processes need to be considered and extended when developing AI- enabled systems. The objective of this study is to identify and classify software engineering challenges that are faced by different companies when developing software-intensive systems that incorporate machine learning components. Using case study approach, we explored the development of machine learning systems from six different companies across various domains and identified main software engineering challenges. The challenges are mapped into a proposed taxonomy that depicts the evolution of use of ML components in software-intensive system in industrial settings. Our study provides insights to software engineering community and research to guide discussions and future research into applied machine learning.
Evolution of Scrum Transcending Business Domains and the Future of Agile Project Management
Authors: Oprins Richard J. J. , Frijns Helena A. , Stettina Christoph J. 
Published: May 2019

AbstractThe growing popularity of Agile management methods has led to their application to a number of areas inside, but also outside, the software development domain. However, despite many practitioner reports, research exploring whether and how Agile practices have been applied in domains beyond software development has been rather patchy with little empirical evidence. What is there behind the hype and how can other domains learn from it? To address this gap in the research, we present the findings of our study on the application of Agile management practices in other domains, including an outlook towards a potential expansion enabling Business Agility. To practitioners, this study presents examples of Scrum applied outside the software development domain including concrete practices applied. To researchers, it presents an empirical starting point for further exploration.
Leadership Gap in Agile Teams: How Teams and Scrum Masters Mature
Authors: Spiegler Simone V. , Heinecke Christoph , Wagner Stefan 
Published: May 2019

AbstractMotivation: How immature teams can become agile is a question that puzzles practitioners and researchers alike. Scrum is one method that supports agile working. Empirical research on the Scrum Master role remains scarce and reveals contradicting results. While the Scrum Master role is often centred on one person in rather immature teams, the role is expected to be shared among multiple members in mature teams.Objective: Therefore, we aim to understand how the Scrum Master role changes while the team matures.Method: We applied Grounded Theory and conducted qualitative interviews with 53 practitioners of 29 software and non-software project teams from Robert Bosch GmbH.Results: We discovered that Scrum Masters initially play nine leadership roles: Method Champion, Disciplinizer on Equal Terms, Coach, Change Agent, Helicopter, Moderator, Networker, Knowledge Enabler and Protector. They transfer some of those roles to the team while it matures. The Scrum Master provides a leadership gap, which allows team members to take on a leadership role.Conclusion: The Scrum Master role changes while the team matures. Trust and freedom to take over a leadership role in teams are essential enablers. Our results support practitioners in implementing agile teams in established companies.
Empowering Agile Project Members with Accessibility Testing Tools: A Case Study
Authors: Stray Viktoria , Bai Aleksander , Sverdrup Nikolai , Mork Heidi 
Published: May 2019

AbstractThere is a growing interest in making software more accessible for everyone, which is emphasized by the numerous suggestions passed into law in many countries. However, many software organizations that use agile methods postpone or neglect accessibility testing. We aimed to understand how accessibility testing can be better integrated into the daily routine of agile projects by conducting a case study in a Norwegian software company. We investigated three accessibility testing tools: automatic checker, simulation glasses, and a dyslexia simulator. We hosted sessions at which agile project members used the tools while thinking out loud, responded to questionnaires, and were interviewed at the end. Additionally, we observed the project members for 18 workdays. Our results show that all three tools are suitable for agile projects. Especially the automatic checker and simulation glasses worked well in finding accessibility issues and were described as easy to use by the project members. Software organizations should empower their agile project members with low-cost and efficient accessibility testing tools to make their products more accessible for all. Doing this early and often in the development cycle may save the project from potential high costs at a later stage.
Ramp lesions are frequently missed in ACL-deficient knees and should be repaired in case of instability
Authors: Bumberger Alexander , Koller Ulrich , Hofbauer Marcus , Tiefenboeck Thomas Manfred , Hajdu Stefan , Windhager Reinhard , Waldstein Wenzel 
Published: May 2019

Abstract
Purpose
The aim of the current study was (1) to provide an overview of common definitions and classification systems of ramp lesions (RL) and (2) to systematically review the available literature with regard to the diagnosis and treatment of RLs in anterior cruciate ligament (ACL)-deficient knees.

Methods
Following the PRISMA guidelines, MEDLINE and Scopus were searched for articles (1) reporting on acute or chronic ACL injuries, (2) with concomitant medial meniscus injury, (3) located at the posterior meniscocapsular attachment site (and red–red zone). Ex vivo studies, reviews and technical notes were excluded.

Results
Twenty-seven studies were included based on the criteria mentioned above. RLs are common in ACL-deficient knees with a prevalence ranging from 9 to 24%. RLs should especially be suspected in younger patients, patients with an increased meniscal slope and in patients with prolonged time from injury to surgery. The sensitivity of MRI for the detection of RLs ranges from 48 to 86% at a specificity of 79–99%. For arthroscopy, RLs are easily missed through standard anterior portals (sensitivity 0–38%). RL repair leads to a significant improvement of subjective knee scores, regardless of the specific fixation technique. For stable RLs, the literature suggests equivalent postoperative stability for trephination and abrasion compared to surgical RL repair.

Conclusion
Ramp lesions are frequently missed in ACL-deficient knees on standard arthroscopy with anterior portals only. If a RL is suspected, exploration via an additional posteromedial portal is indicated. In case of instability, RL repair should be performed.

Level of evidence
IV.
Sexuelle Orientierung im therapeutischen Kontext. Thematische Besonderheiten in der Beziehungsgestaltung mit homo- und bisexuellen Patient*innen
Authors: Höfner Claudia , Ginkel Kai , Käfer-Schmid Gerald 
Published: May 2019

ZusammenfassungDie Sozialisation homo- und bisexueller Menschen birgt innerhalb der heteronormativen Mehrheitsgesellschaft einige Besonderheiten, die in Bezug auf die therapeutische Beziehung reflektiert werden müssen. Sie sehen sich häufig Erfahrungen von Stress, Problematisierung und Diskriminierung ausgesetzt. Es fehlt überdies oft an positiven Rollenvorbildern. Der vorliegende Beitrag reflektiert diese Besonderheiten etwa in Bezug auf das Coming-out als lebenslangen Prozess oder die Überwindung einer oftmals internalisierten Homonegativität. Hierbei steht als Zielsetzung der Einsatz für eine bessere, barriere- und diskriminierungsarme Gesundheitsversorgung und Behandlung durch kompetente und wertschätzende Fachkräfte im Mittelpunkt.
Konstruktionen und Kulturen von Krankheit aus Gender-Perspektive
Authors: Zehetner Bettina 
Published: May 2019

ZusammenfassungIm Bereich der Norm sind Krankheit und Geschlecht eng miteinander verknüpft. In Krankheitsbildern, ihrer Interpretation und Behandlung werden „Männlichkeit“ und „Weiblichkeit“ inszeniert. Geschlechtsspezifische Krankheitsformen beinhalten darum auch kritisches Potenzial, indem sie das Leiden an Geschlechternormen demonstrieren. Bestimmte psychosomatische Störungsbilder treten bei Männern und Frauen in unterschiedlicher Häufigkeit auf und sind unterschiedlich sozial „legitim“: Essstörungen, Angststörungen und Depressionen sind vom Rollenbild her eher „akzeptabel“ für Frauen als für Männer – Frauen, das psychosomatische Geschlecht? Anhand diverser Störungsbilder wird gezeigt, wie die Anpassung an überfordernde Verhältnisse und widersprüchliche Geschlechternormen krank machen kann und wie umgekehrt Krankheit als Verweigerung von Anpassung durchaus ein Zeichen psychischer Gesundheit sein. Abschließend werden Ansätze für eine emanzipatorisch wirksame Haltung in der Psychotherapie diskutiert.
Population-based simulation optimization for urban mass rapid transit networks
Authors: Schmaranzer David , Braune Roland , Doerner Karl F. 
Published: May 2019

AbstractIn this paper, we present a simulation-based headway optimization for urban mass rapid transit networks. The underlying discrete event simulation model contains several stochastic elements, including time-dependent demand and turning maneuver times as well as direction-dependent vehicle travel and passenger transfer times. Passenger creation is a Poisson process that uses hourly origin–destination-matrices based on anonymous mobile phone and infrared count data. The numbers of passengers on platforms and within vehicles are subject to capacity restrictions. As a microscopic element, passenger distribution along platforms and within vehicles is considered. The bi-objective problem, involving cost reduction and service level improvement, is transformed into a single-objective optimization problem by normalization and scalarization. Population-based evolutionary algorithms and different solution encoding variants are applied. Computational experience is gained from test instances based on real-world data (i.e., the Viennese subway network). A covariance matrix adaptation evolution strategy performs best in most cases, and a newly developed encoding helps accelerate the optimization process by producing better short-term results.
Distribution and ignorance
Authors: Räikkä Juha 
Published: May 2019

AbstractAccording to the so-called presumption of equality, a person who does not know whether there is an acceptable reason for differential treatment should just presume the similarity of the cases and treat them equally. If we assume that the presumption of equality is an acceptable moral principle, at least when the allocation cannot be postponed and an equal distribution of goods is possible, then an important question arises: when exactly does the allocator have sufficient reasons for differential treatment and is not relevantly ignorant? This is a question about the required strength of the “acceptable reasons” for differential treatment. It has been commonplace to think that the presumption of equality demands that the reasons that refute the presumption must be very strong and that differential treatment requires that there is a proper justification for the claim that the cases are relevantly different. I will argue, however, that refuting the presumption and solving the issue (of whether the cases are relevantly similar or relevantly different) are two separate matters. A person can have good enough reasons for rejecting the presumption that the cases are relevantly similar without having reasons that she could present as a full justification for the claim that the cases are relevantly different. A precondition of the applicability of the presumption of equality is ignorance, but not ignorance in the sense of “not having a full justification”.