bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing self-management: a mixed-methods study of women’s experiences of a postpartum hypertension intervention
Authors: Cairns Alexandra Elspeth , Tucker Katherine L. , Crawford Carole , McManus Richard J. , Powell John 
Published: August 2019

Abstract
Background Self-management strategies are effective in a number of medical conditions; however, implementation studies have demonstrated that adoption into clinical practice can be problematic. The process of implementation was explored during a pilot randomised controlled trial evaluating postpartum blood pressure self-management, in women with medicated hypertensive disorders of pregnancy. Methods A mixed methods study using semi-structured interviews with both a qualitative and a scored (quantitative) component were undertaken as part of a pilot randomised controlled trial in postnatal women with medicated gestational hypertension or pre-eclampsia. Women were randomised to usual care or blood pressure self-management. Self-management entailed daily home blood pressure monitoring and automated medication reduction via telemonitoring. Women from both groups consented to participate in audio-recorded interviews, at four weeks and six months postpartum. Interview questions were developed to explore the proposed benefits of self-management and the constructs of Normalisation Process Theory. Participants provided a score (Likert scale 1-5) for each question and were encouraged to expand upon these answers through further discussion. The interviews were transcribed and analysed using the framework approach. Results Sixty-eight women, 34 from each randomised group, completed at least one audio-recorded interview. Several overarching themes emerged from analysis of 126 interview transcripts: control; convenience; confidence, communication and knowledge; concern; constraints; and components of the intervention. In the scored component of the analysis, both groups reported feeling more in control of their condition postpartum compared to during pregnancy, more so in those self-managing at both four weeks and six months: adjusted differences 0.6 (95% confidence interval (CI) 0.2 to 1.1) and 0.7 (95% CI 0.3 to 1.2) respectively. Conclusions Interviews and quantitative data showed that self-management enhanced women’s sense of control, and improved their blood pressure-related anxiety. Prior to taking part, a few women anticipated that home monitoring might increase anxiety, but stated that it had the opposite effect. Self-management was perceived as more flexible, reactive and as enabling more targeted down-titration of medication. These data provide considerable support for blood pressure self-management postpartum, and reinforce the effectiveness of the intervention used in this study. Trial registration Prospectively registered with ClinicalTrials.gov on 07/01/2015 (NCT02333240) https://clinicaltrials.gov/ct2/show/NCT02333240.
High-throughput screening reveals novel mutations in spinal muscular atrophy patients
Authors: Shu Jianbo , Wang Jingrui , Fang Yulian , Xu Zanmei , Wang Xiaowei , Meng Yingtao , Cai Chunquan 
Published: August 2019

Abstract
Background Some spinal muscular atrophy (SMA) cases are caused by either compound heterozygosity with a point mutation in one allele and a deletion in the other or compound heterozygous point mutations in SMN1 or other genes. Methods To explore more genes and mutations in the onset of SMA, 83 whole blood samples were collected from 28 core families of clinically suspected SMA, and multiplex ligation probe amplification (MLPA) was firstly performed with a SALSA MLPA Kit P021 for preliminary diagnosis. Afterwards, the complete gene sequence of SMN1 gene was detected with the high-throughput sequencing platform of Illumina HiSeq-2500 to find more mutations in the 28 core families. Furthermore, 20 SMA patients were selected from the 28 prodands, and 5 non SMA children as controls. The Life Technologies SOLiD™ technology with mate-pair chemistry was utilized to conduct the whole exome high-throughput sequencing. Results MLPA results showed that 22 probands were SMA patients, 3 probands carriers, and 3 probands normal individuals. Moreover, 2 parents from 2 SMA families were with 3 SMN1 exon7 copies. 6 SMN1 single nucleotide variants (SNVs) were identified in the 83 samples, and c.[84C>T], c.[271C>T], c.[-39A>G] and g.[70240639G>C] were novel. Compared with control group, 9102 mutation were selected out in SMA patients. SPTA1 mutation c.[-41_-40insCTCT], FUT5 SNV c.[1001A>G], and MCCC2 SNV c.[-117A>G] were the 3 most frequent mutations in SMA group (95%, 85% and 75%, respectively). Conclusions We identified some mutations in both SMN1 and other genes, and c.[271C>T], c.[-41_-40insCTCT], c.[1001A>G] and c.[-117A>G] might be associated with the onset of SMA.
Evaluation of small ncRNAs as a possible epigenetic mechanism mediating the transition from biotrophy to necrotrophy in the life cycle of Phytophthora infestans
Authors: Gonzalez-Tobon Juliana , Rodriguez-Jaramillo Alejandra , Forero Laura Milena , González Laura Natalia , Danies Giovanna , Restrepo Silvia 
Published: August 2019

Abstract
Background

Phytophthora infestans, the causal agent of late blight disease of potato and tomato, is responsible for billions of dollars in losses worldwide each year. This plant pathogen is a hemibiotroph, meaning that in the early stages of infection, it feeds on living host tissue, and later in the infection cycle, it kills the host. Even though the transcription dynamics of this transition are well characterized, information on the role of small noncoding RNAs (ncRNAs) during this process is still being obtained. Furthermore, a methodological pipeline useful for searching and analyzing small ncRNAs in this pathogen is needed.

Results

Using the proposed pipeline, a set of 146 small ncRNAs were found to be significantly differentially expressed among the analyzed samples. From these, 100 small ncRNAs were successfully annotated to specific genes, some of them encoding effector proteins produced by the pathogen during its life cycle. Other molecular regulatory processes, mainly mediated by enzymes and transporters, were also identified.

Conclusions

The pipeline presented here is an easy-to-use, comprehensive and efficient option for analyzing small ncRNA profiles of P. infestans small RNA-seq data sets. Additionally, the results presented here may further contribute to elucidating the specific molecular and epigenetic mechanisms controlling the life cycle of P. infestans.
Correlation of prostatic morphological parameters and clinical progression in aging Chinese men with benign prostatic hyperplasia: results from a cross-sectional study
Authors: Qian Subo , Shen Haibo , Zhang Shun , Gu Jun , Qi Jun , Wu Yu 
Published: August 2019

Abstract
Objectives

Our study aimed to investigate the correlation of prostatic morphological parameters and benign prostatic hyperplasia (BPH) clinical progression in aging Chinese men.

Methods

In this retrospective study, a total of 1038 patients were reviewed. Prostatic morphology was measured by transrectal ultrasound (TRUS). Detailed medical history of all candidates were recorded and analysed after being classified by specific prostatic measurements. Univariate and multivariate logistic regression analyses were used to estimate the correlation between variables.

Results

The cumulative incidence of BPH clinical progression was 63.68% (661/1038) in study population. Prostate volume (PV), transitional zone volume (TZV), transitional zone index (TZI) and intravesical prostatic protrusion (IPP) were all positively associated with BPH progression (all p < 0.001). Patients with a PV > 60 mL, TZV > 15 mL, TZI > 0.5 or IPP > 5 mm had a significantly higher possibility of overall BPH clinical progression (adjusted odds ratio (OR): 2.485, 1.678, 1.886 and 1.924, respectively; 95% confidence interval (CI): 1.559-3.960, 1.131-2.489, 1.379-2.579 and 1.357-2.728, correspondingly).

Conclusion

Prostatic morphological parameters are significantly associated with BPH clinical progression. Patients with larger prostatic morphological parameters are more easily to progress. As a result, reasonable management should be timely considered for those patients before clinical progression occurs.
Risk factors for sensation of pain during photocoagulation for diabetic retinopathy - a prospective observational study
Authors: Bystrup Louise Kjærgaard , Bek Toke 
Published: August 2019

Abstract
Background

Diabetic retinopathy can be treated by retinal photocoagulation. The treatment may induce discomfort and pain, and due to the individual variation of these adverse effects, it is a challenge to inform patients and to minimise discomfort during treatment.

Methods

The subjective sensation of pain was evaluated on a numeric rating scale from 0 – 10 in 235 successive patients receiving macular photocoagulation (MP) and 174 patients receiving panretinal photocoagulation (PRP). The influence of first/second eye, treatment session, gender, age, diabetic type, diabetic treatment, duration of diabetes, mean arterial pressure (MAP), body mass index (BMI), glycosylated haemoglobin (HbA1c), visual acuity, right/left eye, number, spot size and effect of applications on the perceived pain was studied.

Results

The pain score was significantly lower (p<0.001) after the first treatment in the first eye in patients treated with MP 1.67 ±1.8, n=235 (mean ±SD, n) than in patients treated with PRP 2.67 ±2.4, n=174 (mean ±SD, n). Lower mean arterial pressure, higher HbA1c and higher number and effect of the applications contributed significantly to increasing the reported pain during the first treatment in the first eye. For all patients treated in both eyes the reported pain was significantly (p<0.001) higher in the second 2.74 ±2.40, n=269 (mean ±SD, n) than in the first 2.08 ±2.14, n=269 (mean ±SD, n) eye. The pain was significantly higher during the two last than during the first treatment session in patients who received panretinal photocoagulation (p<0.001).

Conclusions

The higher pain during high treatment intensity and treatment in the retinal periphery might prompt a fractioning of treatment in patients with a low pain threshold. The increased pain with increasing HbA1c and decreasing MAP might be used to individualize information about treatment and to prepare health care professionals about the reactions of the patients.
Thirty patients with one-stage hip arthroplasty and multiple drilling decompression for bilateral osteonecrosis of the femoral head:outcomes at two-year follow up
Authors: Ding Lu , Gao Yu-Hang , Zhang Shi , Huang Yi-Fan , Liu Jian-Guo , Qi Xin 
Published: August 2019

Abstract
Background: To investigate the postoperative outcome of decompresed hip following contralateral replacement in patients with bilateral osteonecrosis of the femoral head (ONFH).
M ethods: This study retrospectively reviewed 30 patients with bilateral ONFH who underwent one-stage total hip arthroplasty (THA) and multiple drilling decompression from February 2014 to February 2016. For all patients, alendronate was prescribed. Postoperative Harris Hip Scores (HHSs), Oxford Hip Scores (OHSs), Self-Administered Patient Satisfaction (SAPS), hip internal and external rotation angles, and the time of one-leg standing were evaluated. All patients were followed up for an average of 30.33 months (ranged from 8 months to 48 months).
Results: Twenty-four patients had no progression or collapse on radiographic evaluation within 2 years postoperatively. The following scores of the decompressed sides were significantly lower than those of the replaced sides: HHSs (mean: 96.5 versus 98.25, P <0.05), SAPS (mean: 96.35 versus 99.48, P <0.001), internal rotation (mean: 27.58° versus 30.50°, P <0.05), and the time of single-leg standing (mean: 24.17 s versus 31.83 s, P <0.05). There was no significant difference in OHSs and external rotation between the sides. The remaining 6 patients underwent two-stage THA on the decompressed sides within 2 years. Four of them underwent THA for severe pain and femoral head collapse. The other 2 patients showed no progression on radiographic evaluation but complained of an uncomfortable feeling in the joint.
Conclusions: One-stage THA and multiple drilling decompression are effective surgical procedures for bilateral ONFH at different stages. However, a few patients with no progression on radiographic evaluation may require two-stage THA on the decompressed sides because of more pain, poorer internal rotation, and weaker gluteal muscle strength when compared with the replaced sides.
Keywords: osteonecrosis of the femoral head, postoperative satisfaction, total hip arthroplasty, multiple drilling decompression
Prevalence And Factors Associated With Hypertriglyceridemic Waist In Colombian Elderly.
Authors: Rincón-Pabón David , Urazán-Hernández Yeraldin , Gómez-Rodas Alejandro , Martinez-Torres Javier 
Published: August 2019

Abstract
Background: The purpose of this study to analyze the prevalence of hypertriglyceridemic waist and associated factors in older individuals aged ≥60 years in Colombia.
Methods: The data for this study came from a secondary cross-sectional, nationally representative SABE study Survey on Health, Well-Being, and Aging in Colombia, 2015. A total of 3824 participants (59.7% male, 69 (IR=64-76) years) from 86 Colombian municipalities participated. The data were collected through a questionnaire, blood tests, blood pressure measurements and anthropometric measurements. The hypertriglyceridemic waist phenotype was diagnosed using high triglyceride values (≥ 150 mg / dl) and increased waist circumference ≥ 88 and ≥ 102 cm for women and men, respectively. A logistic regression analysis was used to compare the hypertriglyceridemic waist phenotype and the associated factors, significance level of 5%. STROBE checklist for cross‐sectional studies was applied in this paper (see Supplementary File 1).
Results: The hypertriglyceridemic waist was present in 38.7% of the study population, with a higher prevalence among females than males (44.6% vs. 30.0%). Female gender [odds ratio (OR) 1.9 (95% confidence interval (CI) 1.6-2.2)]; be octogenarian [OR 0.7 (95% CI 0.6-0.9)]; live in an urban area [OR 1.5 (95% CI 1.3-1.8)] and have a lifestyle of former smoker [OR 0.8 (95% CI 0.7-0.9)]. On the other hand, it was observed that having a BMI different from normal is strongly associated with HTGW [Weight: OR 2.0 (95% CI 1.5-2.6), overweight: OR 4.1 (95% CI 3.4 -4.9) and obesity: OR 5.0 (95% CI 4.1-6.1)]. The glycemia, the hemoglobin and the increase in cholesterol also showed positive association with HTGW [OR 0.5 (95% CI 0.5-0.7), OR 2.1 (95% CI 1.8-2.4) and OR 2.1 (95% CI 1.9-2.5), respectively] were associated with increased odds of HTGW.
¬Conclusions: There is a significant prevalence of hypertriglyceridemic waist in Colombia's elderly and sociodemographic factors, lifestyles and biological markers are associated with the hypertriglyceridemic waist phenotype. Elderly men showed greater probabilities in terms of age, schooling, geographic area, body mass inde and cholesterol concentrations. Elderly women revealed higher probabilities in biological markers
The risk factor of postpartum hemorrhage after cesarean section for placenta previa: A retrospective study
Authors: Ishibashi Hiroki , Miyamoto Morikazu , Soyama Hiroaki , Iwahashi Hideki , Kawauchi Haruka , Takasaki Kazuki , Matuura Hiroko , Nakatsuka Masaya , Hada Taira , Takano Masashi 
Published: August 2019

Abstract
Background Placenta previa could induce postpartum hemorrhage (PPH). Even cases with less intraoperative hemorrhage during cesarean section had the potential risk to develop PPH. But, there were less report about the predictive factor of PPH associated with placenta previa. The aim of this study was to identify the predictive factor for PPH for women with placenta previa after cesarean section.
Methods Women with placenta previa who underwent cesarean section at our institution between January 2003 and February 2015 were identified. Women that received any hemostatic procedure such as intrauterine balloon tamponade and gauze infiltration during cesarean section were excluded. All women were classified into two groups: Group A or with PPH, defined as over 500 ml of hemorrhage after cesarean section, and Group B or without PPH. A retrospective analysis to identify the predictive factor of PPH was conducted.
Results Out of 128 women, 10 (7.8%) women were included in Group A and 118 (92.2%) women in Group B. There was no statistical significance in maternal history between both groups. The number of women suspected to have placental adhesion was higher in Group A than Group B (p=0.006). Furthermore, the amount of intraoperative hemorrhage in Group A was higher than that in Group B (p=0.025). As treatment for PPH, more women in Group A received allogenic blood transfusion (p=0.003), and uterine artery embolization (p = 0.010). In univariate analysis, placental adhesion suspected by surgeon during cesarean section was the predictive factor for PPH with placenta previa (p=0.046).
Conclusion When placental adhesion is suspected by surgeons during cesarean section, additional hemostatic procedure should be performed for possible PPH.
Research on vibration characteristics of a multi-barrel artillery
Authors: Wu Yingfeng , Cheng Qingsi , Yang Guolai , Dai Jinsong 
Published: August 2019

The vibration of the barrel, induced by the interaction with a high-speed moving projectile, has a considerable influence on the shooting accuracy of a weapon. The finite element model of a multi-barrel was established with the goal to investigate its vibration characteristics in this paper, and the natural frequency and mode shape were analyzed by finite element method. To verify the result of finite element modal analysis (FEMA), a modal testing system basis on SC310W multi-path data-collecting system and hammer hitting method was set up. Results show that the low order vibrations of the multi-barrel artillery were mainly vertical, horizontal and torsional vibration, but the local vibration at high orders. The error of natural frequencies between the results obtained by simulation and test was 8.82 % in the first mode frequency and 1.37 % in the eighth. The FEMA can effectively simulate the actual vibration of the multi-barrel artillery.
Using a Large Margin Context-Aware Convolutional Neural Network to Automatically Extract Disease-Disease Association from Literature: Comparative Analytic Study
Authors: Lai Po-Ting , Lu Wei-Liang , Kuo Ting-Rung , Chung Chia-Ru , Han Jen-Chieh , Tsai Richard Tzong-Han , Horng Jorng-Tzong 
Published: August 2019

Background
Research on disease-disease association (DDA), like comorbidity and complication, provides important insights into disease treatment and drug discovery, and a large body of the literature has been published in the field. However, using current search tools, it is not easy for researchers to retrieve information on the latest DDA findings. First, comorbidity and complication keywords pull up large numbers of PubMed studies. Second, disease is not highlighted in search results. Finally, DDA is not identified, as currently no disease-disease association extraction (DDAE) dataset or tools are available.

Objective
As there are no available DDAE datasets or tools, this study aimed to develop (1) a DDAE dataset and (2) a neural network model for extracting DDA from the literature.

Methods
In this study, we formulated DDAE as a supervised machine learning classification problem. To develop the system, we first built a DDAE dataset. We then employed two machine learning models, support vector machine and convolutional neural network, to extract DDA. Furthermore, we evaluated the effect of using the output layer as features of the support vector machine-based model. Finally, we implemented large margin context-aware convolutional neural network architecture to integrate context features and convolutional neural networks through the large margin function.

Results
Our DDAE dataset consisted of 521 PubMed abstracts. Experiment results showed that the support vector machine-based approach achieved an F1 measure of 80.32%, which is higher than the convolutional neural network-based approach (73.32%). Using the output layer of convolutional neural network as a feature for the support vector machine does not further improve the performance of support vector machine. However, our large margin context-aware-convolutional neural network achieved the highest F1 measure of 84.18% and demonstrated that combining the hinge loss function of support vector machine with a convolutional neural network into a single neural network architecture outperforms other approaches.

Conclusions
To facilitate the development of text-mining research for DDAE, we developed the first publicly available DDAE dataset consisting of disease mentions, Medical Subject Heading IDs, and relation annotations. We developed different conventional machine learning models and neural network architectures and evaluated their effects on our DDAE dataset. To further improve DDAE performance, we propose an large margin context-aware-convolutional neural network model for DDAE that outperforms other approaches.
Ataluren use in patients with nonsense mutation Duchenne muscular dystrophy: patient demographics and characteristics from the STRIDE Registry
Authors: Muntoni Francesco , Desguerre Isabelle , Guglieri Michela , Osorio Andrés Nascimento , Kirschner Janbernd , Tulinius Már , Buccella Filippo , Elfring Gary , Werner Christian , Schilling Traci , Trifillis Panayiota , Zhang Olivia , Delage Abdallah , Santos Claudio L , Mercuri Eugenio 
Published: August 2019

Aim:
Strategic Targeting of Registries and International Database of Excellence (STRIDE) is an ongoing, multicenter registry providing real-world evidence regarding ataluren use in patients with nonsense mutation Duchenne muscular dystrophy (DMD) in clinical practice (NCT02369731). Here, we describe the initial demographic characteristics of the registry population.
Patients & methods:
Patients will be followed up from enrollment for ≥5 years or until study withdrawal.
Results & conclusion:
As of 9 July 2018, 213 DMD boys were enrolled from 11 countries. Mean (standard deviation) ages at first symptoms and at study treatment start were 2.7 (1.7) years and 9.8 (3.7) years, respectively. Corticosteroids were used by 190 patients (89.2%) before data cut-off. Mean (standard deviation) ataluren exposure was 639.0 (362.9) days. Six patients withdrew. STRIDE is the first drug registry for patients with DMD and represents the largest real-world registry of patients with nmDMD to date.
Application of cobalt-based alloys of Co–Cr–Si–B system for protective coatings
Authors: Belyakov A. N. , Bystrov R. Yu. , Gerashchenkov D. A. , Vasilyev A. F. , Bobkova T. I. , Makarov A. M. , Prudnikov I. S. , Farmakovsky B. V. 
Published: August 2019

The paper studies an alloy of Co–Cr–Si–B system for obtaining powder materials and functional coatings based on it. It is shown that nanocrystalline precipitates are formed and increase substantially the microhardness of the coating when rare-earth elements, namely yttrium, lanthanum, and cerium, are introduced into the alloy.