bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating microRNAs in the early prediction of disease recurrence in primary breast cancer
Authors: Papadaki Chara , Stratigos Michalis , Markakis Georgios , Spiliotaki Maria , Mastrostamatis Georgios , Nikolaou Christoforos , Mavroudis Dimitrios , Agelaki Sofia 
Published: July 2018

Abstract
Background
In primary breast cancer metastases frequently arise from a state of dormancy that may persist for extended periods of time. We investigated the efficacy of plasma micro-RNA (miR)-21, miR-23b, miR-190, miR-200b and miR-200c, related to dormancy and metastasis, to predict the outcome of patients with early breast cancer.

Methods
miRNAs were evaluated by RT-qPCR in plasma obtained before adjuvant chemotherapy. miRNA expression, classified as high or low according to median values, correlated with relapse and survival. Receiver operating characteristic (ROC) curves were constructed to determine miRNA sensitivity and specificity.

Results
miR-21 (p < 0.001), miR-23b (p = 0.028) and miR-200c (p < 0.001) expression were higher and miR-190 was lower (p = 0.013) in relapsed (n = 49), compared to non-relapsed patients (n = 84). Interestingly, miR-190 was lower (p = 0.0032) in patients with early relapse (at < 3 years; n = 23) compared to those without early relapse (n = 110). On the other hand, miR-21 and miR-200c were higher (p = 0.015 and p < 0.001, respectively) in patients with late relapse (relapse at ≥ 5 years; n = 20) as compared to non-relapsed patients. High miR-200c was associated with shorter disease-free survival (DFS) (p = 0.005) and high miR-21 with both shorter DFS and overall survival (OS) (p < 0.001 and p = 0.033, respectively) compared to low expression. ROC curve analysis revealed that miR-21, miR-23b, miR-190 and miR-200c discriminated relapsed from non-relapsed patients. A combination of of miR-21, miR-23b and miR-190 showed higher sensitivity and specificity in ROC analyses compared to each miRNA alone; accuracy was further improved by adding lymph node infiltration and tumor grade to the panel of three miRs (AUC 0.873). Furthermore, the combination of miR-200c, lymph node infiltration, tumor grade and estrogen receptor predicted late relapse (AUC 0.890).

Conclusions
Circulating miRNAs are differentially expressed among relapsed and non-relapsed patients with early breast cancer and predict recurrence many years before its clinical detection. Our results suggest that miRNAs represent potential circulating biomarkers in early breast cancer.
Aeromagnetic and spectral expressions of rare earth element deposits in Gallinas Mountains area, Central New Mexico, USA
Authors: Li Mo , Zhou Xiaobing , Gammons Christopher H. , Khalil Mohamed , Speece Marvin 
Published: July 2018

The Gallinas Mountains, located at the junction of Lincoln and Torrance Counties, New Mexico, USA, are a series of alkaline volcanic rocks intruded into Permian sedimentary rocks. The Gallinas Mountains area hosts fluorite and copper as veins containing bastnäsite, whereas deposits of iron skarns and iron replacement are in the area as well. These deposits produce iron. In this study, the multispectral band-ratio method is used for surface mineral recognition, whereas 2D subsurface structure inversion modeling was applied to explore the depth extent of the magnetic ore distribution from aeromagnetic data. Bastnäsite has higher magnetic susceptibility (0.009 SI) than the host rocks and surrounding sedimentary rock. The bastnäsite and iron oxides (magnetite + hematite) can contribute to a positive aeromagnetic anomaly. Results indicate that (1) the positive magnetic anomaly observed at Gallinas Mountains area can be accounted for by a mixture of bastnäsite and iron oxides at a depth of approximately 400 m and a thickness of approximately 13–15 m. The surface of this area is dominated by the hydrothermal alteration associated with iron oxides over the trachyte intrusions as detected by Landsat 8 band-ratio imaging.
Rationale and Design of the Targeted Agent and Profiling Utilization Registry Study
Authors: Mangat Pam K. , Halabi Susan , Bruinooge Suanna S. , Garrett-Mayer Elizabeth , Alva Ajjai , Janeway Katherine A. , Stella Philip J. , Voest Emile , Yost Kathleen J. , Perlmutter Jane , Pinto Navin , Kim Edward S. , Schilsky Richard L. 
Published: July 2018

Purpose Case reports and small prospective trials suggest that administering targeted therapies to patients with advanced cancer and an identified genomic target may be associated with clinical benefit. The Targeted Agent and Profiling Utilization Registry (TAPUR) study, a phase II prospective, nonrandomized, multibasket pragmatic clinical trial, aims to identify signals of drug activity when US Food and Drug Administration–approved drugs are matched to prespecified genomic targets in patients with advanced cancer, outside of approved indications. Methods Patients eligible to participate in TAPUR are age ≥ 12 years and have advanced measurable or evaluable solid tumors, multiple myeloma, or B-cell non-Hodgkin lymphoma. Eligible participants are matched to any of the 16 US Food and Drug Administration–approved study drugs based on protocol-specified genomic inclusion and exclusion criteria. Genomic profiling from any Clinical Laboratory Improvement Amendments–certified, College of American Pathologists–accredited laboratory is acceptable. The treating physician selects the treatment from the available study therapies or consults with the TAPUR Molecular Tumor Board. Participants are placed into multiple parallel cohorts defined by tumor type, genomic alteration, and drug. The primary study end point within each cohort is objective response or stable disease of at least 16 weeks duration. Secondary end points include safety, progression-free survival, and overall survival. Results More than 1,000 participants have thus far been registered, and more than 800 have been treated with a TAPUR study drug. Two study cohorts have permanently closed to enrollment because of lack of antitumor activity, and 12 have expanded to the second stage of enrollment after promising preliminary activity. Conclusion The TAPUR study will describe the efficacy and toxicity of the targeted drugs used outside of their approved indications when matched to a somatic genomic variant.
Age and Sex Are Critical Factors in Ischemic Stroke Pathology
Authors: Roy-O’Reilly Meaghan , McCullough Louise D 
Published: July 2018

AbstractIschemic stroke is a devastating brain injury resulting in high mortality and substantial loss of function. Understanding the pathophysiology of ischemic stroke risk, mortality, and functional loss is critical to the development of new therapies. Age and sex have a complex and interactive effect on ischemic stroke risk and pathophysiology. Aging is the strongest nonmodifiable risk factor for ischemic stroke, and aged stroke patients have higher mortality and morbidity and poorer functional recovery than their young counterparts. Importantly, patient age modifies the influence of patient sex in ischemic stroke. Early in life, the burden of ischemic stroke is higher in men, but stroke becomes more common and debilitating for women in elderly populations. The profound effects of sex and age on clinical ischemic stroke are mirrored in the results of experimental in vivo and in vitro studies. Here, we review current knowledge on the influence of age and sex in the incidence, mortality, and functional outcome of ischemic stroke in clinical populations. We also discuss the experimental evidence for sex and age differences in stroke pathophysiology and how a better understanding of these biological variables can improve clinical care and enhance development of novel therapies.
Electrical conductivity for seed vigor test in sorghum (Sorghum bicolor)
Authors: FATONAH KHODRATIEN , SULIANSYAH IRFAN , ROZEN NALWIDA 
Published: July 2018

Fatonah K, Suliansyah I, Rozen N. 2017. Electrical conductivity for seed vigor test in sorghum (Sorghum bicolor). Cell Biol Dev 1: 6-12. The objectives of this study were to obtain electrical conductivity test method for seed vigor test in sorghum, to recognize relationship between electrical conductivity test and potassium leakage, and to recognize relationship between electrical conductivity test and other variable on seed vigor. This study have two step experiments. The objective of Experiment I was to determine accurate combinations of water volume and amount seed of the electrical conductivity test for seed vigor test in sorghum. Completely Randomized Design of 15 seed lots with 3 replications were used to determine electrical conductivity method with different vigor. Experiment II were to test electrical conductivity method of 21 seed lots of sorghum without accelerated aging test and 21 seed lots of sorghum were given accelerated aging test. Completely Randomized Design of 21 seed lots with 3 replications were used in Experiment II. The variable were observed : standard germination, field emergence, speed of germination, first count, conductivity, potassium leakage and eight combination conductivity method of water volume (50, 100, 150 and 200 ml) and amount of seed sorghum (50 and 75 seed count). The result of this experiments showed that electrical conductivity test method with 150 ml water volume and 75 seed count was accurate and suitable for sorghum seed vigor test; electrical conductivity test showed positive correlation with potassium leakage;and electrical conductivity test can be used for seed vigor test in sorghum and provided the potential of physiological seed were shown through : standard germination test, field emergence test, first count test and speed of germination with negative correlation.
The European Council in view of external security and international threats to the European Union. Between idealism and realism
Authors: CZACHÓR ZBIGNIEW 
Published: July 2018

W dążeniu do realizacji celów Rady Europejskiej w zakresie działań zewnętrznych traktat lizboński stworzył nowy kontekst instytucjonalny. Opiera się on na wzroście zarówno potencjału jak i ambicji RE, które może realizować ona przez wykorzystanie pełnej gamy instrumentów i zasobów – w dążeniu do działań bardziej skutecznych i o większym znaczeniu strategicznym. Uznano zatem, że koncepcje i zasady regulujące kompleksowe podejście Rady Europejskiej zyskać muszą rangę zasad przewodnich działań zewnętrznych UE we wszystkich dziedzinach, w szczególności w odniesieniu do bezpieczeństwa, zapobiegania konfliktom i reagowania w sytuacjach kryzysowych. Z tego względu Rada Europejska określiła szereg konkretnych działań, które podejmuje, dążąc do osiągnięcia coraz bardziej kompleksowego podejścia w polityce i działaniach z zakresu stosunków zewnętrznych. Dla realizacji tego zadania (co precyzyjnie analizuje powyższy tekst) zajęto się wszystkimi aspektami zagrożeń dla bezpieczeństwa płynących z konfliktów i kryzysów zewnętrznych – od wczesnego ostrzegania i gotowości, poprzez zapobieganie konfliktom oraz reagowanie i zarządzanie kryzysowe, aż po wczesny etap wychodzeniaz kryzysu oraz budowania stabilizacji i pokoju. Zdaniem Rady Europejskiej – co wykazuje niniejszy tekst – konieczność wzajemnie uzupełniających się interwencji w obszarach bezpieczeństwa zewnętrznego i zagrożeń dla Unii Europejskiej jest efektem nowych problemów międzynarodowych w skali globalnej. Rada Europejska konsekwentnie podkreśla, że bezpieczeństwo jest niezbędnym warunkiem stabilności UE i że trwały pokój nie jest możliwy bez rozwoju i eliminacji zagrożeń i ryzyk. Dla Rady Europejskiej tworzenie i wzmacnianie warunków politycznych, społecznych i gospodarczych dla stabilności ma zasadnicze znaczenie dla bezpieczeństwa i jest warunkiem wstępnym zmian w unijnej polityce zewnętrznej. Ta współzależność między bezpieczeństwem i stabilnością odgrywa kluczową rolę w zwiększaniu skuteczności działań zewnętrznych UE. Każde państwo, które dąży do zapewnienia bezpieczeństwa i pokoju, musi posiadać lub nabyć odpowiednie zdolności we wszystkich istotnych obszarach, w tym w obszarz bezpieczeństwa i obrony. Umożliwi to nie tylko ustabilizowanie sytuacji na świecie, ale również przyczyni się w sposób konstruktywny do zaprowadzenia pokoju, uzyskania stabilizacji i zapobiegania kryzysom. Na przestrzeni ostatnich lat UE w coraz większym zakresie wspierała tę współzależność między bezpieczeństwem i antykryzysową stabilnością, prowadząc interwencje w różnych obszarach polityki unijnej i korzystając z różnych instrumentów. Działania te obejmują m.in. dostęp do instrumentów międzynarodowych, dialog polityczny, współpracę techniczną (w tym wspólne badania naukowe i innowacje) oraz szkolenia (transfer wiedzy oraz rozwój umiejętności).
Relationships Between Eccentric and Concentric Knee Strength Capacities and Maximal Linear Deceleration Ability in Male Academy Soccer Players
Authors: Harper Damian J. , Jordan Alastair R. , Kiely John 
Published: July 2018

Abstract
Harper, DJ, Jordan, AR, and Kiely, J. Relationships between eccentric and concentric knee strength capacities and maximal linear deceleration ability in male academy soccer players. J Strength Cond Res 35(2): 465–472, 2021—The purpose of this study was to investigate the relationships between maximal linear deceleration ability, and knee flexor (KF) and knee extensor (KE) strength. Fourteen male academy soccer players completed a 30-m linear sprint, a maximal linear deceleration test, and eccentric and concentric KF and KE contractions in both dominant leg (DL) and nondominant leg (NDL) at slower (60°·s−1) and faster (180°·s−1) angular velocities on an isokinetic dynamometer. Maximal linear deceleration ability was evaluated using distance-to-stop (DEC-DTS) and time-to-stop (DEC-TTS), with isokinetic peak torque representing KF and KE strength capacity. Relationships were established using Pearson's correlation coefficients (r) with magnitude-based inferences used to describe the uncertainty in the correlation. Both concentric KE and KF strength at 180°·s−1 in the NDL had the highest correlations with deceleration ability (r = −0.76 and r = −0.78, respectively). In the DL, concentric KE and KF strength at 180°·s−1 also had very likely large correlations with deceleration ability (r = −0.54 and −0.55, respectively). All correlations between eccentric KF strength and deceleration ability were unclear. At 180°·s−1, correlations between eccentric KE strength and deceleration ability were also unclear; however, at 60°·s−1, both DL (r = −0.63 to −0.64) and NDL (r = −0.54 to −0.55) had very likely large correlations with deceleration ability. These findings provide novel insights into the unilateral KF and KE strength capacities underpinning the ability to decelerate rapidly from high-sprint velocities.
EARLY CONGENITAL SYPHILITIC PSEUDOPARALYSIS (PARROT’S DISEASE): A CLINICAL CASE
Authors: Belyaletdinova Ilmira Kh. , Mitrofanova Irina V. , Kirichenko Tatjana V. , Abramova Elena N. , Arsenyeva Tatjana V. , Bazarova Marina V. , Shakhgildyan Svetlana V. 
Published: July 2018

Background.Congenital syphilis is a severe intrauterine infection which, affecting most of the organs and systems of a child, can lead to his disability. However, it is extremely difficult to suspect congenital syphilis in a child in the absence of information about prior syphilis in his mother. The article presents a case of a monosymptomatic clinical picture of early congenital syphilis.Description of the Clinical Case. At the age of 1 month, the child had hyperemia, isolated edema of the right forearm, and restriction of limb movements. He was examined by a pediatrician who suspected a fracture of the forearm bones. X-ray did not show any fracture. The situation was regarded as an allergic reaction; desensitizing therapy was prescribed during which the range of movements in the right arm slightly increased. At the age of 2 months, there was a decrease in the range of movements in the left arm. On admission, the condition was regarded as moderate one. No fever; no signs of intoxication. Skin and visible mucous membranes were not changed. Cardiopulmonary activity was satisfactory. The abdomen was palpable in all compartments, painless. The liver was enlarged 6 cm, of dense consistency. The spleen was enlarged 5 cm. Bowel and bladder functions were normal. Neurological status: the reaction to examination was adequate, emotional cry. Cranial nerves without pathology. Can see and hear. Restricted range of movements in the arms; passive movements were painful. Muscle tone in the arms was low, in the legs — closer to physiological one. Equal and brisk tendon reflexes from the arms and legs. Large fontanel 1.5[1]1.5 cm, not protruded. X-ray examination of the forearm bones showed a change in the structure of the epiphyses of both forearm bones that was common to syphilitic osteochondritis.Conclusion. The article describes the complexity of diagnosis of early congenital syphilis in a child aged 2 months in the absence of a corresponding anamnesis in his mother. The need to rule out syphilitic infection in infants with motor impairments, born from unexamined mothers, has been emphasized.
Yabancıların Havayolu Ulaşımını Tercih Etme Nedenleri: Türkiye'ye Ait Havayolu İşletmeleri Üzerine Bir Araştırma
Authors: CANÖZ Nilüfer 
Published: July 2018

Havayolu ulaşımı; hızı,
sağladığı konforu ve farklı uygulamalarıyla her geçen gün insanlar tarafından
daha çok tercih edilmeye başlanmıştır. İnsanların havayolu ulaşımını tercih
etmeye başlamasıyla da sektörde hizmet verecek işletme sayısı hızla
çoğalmaktadır. Sektördeki ulusal ve uluslararası yasal düzenlemeler, ağır
maliyetler, sunulan hizmetlerin birbirine benzemesi vb. koşullar altında
birbiri ile rekabet etmek zorunda kalan işletmeler, avantajlı duruma geçebilmek
için kendilerini tercih edebilmelerinde etkili olabilecek alternatifler
aramakta, stratejiler belirlemektedir. İşletmelerin uyguladıkları bu alternatif hizmetlerin
yolcular üzerinde etkili olup olmadığı ise araştırılması gereken bir durumdur.
Özellikle de yabancıların havayolu işletmelerini tercih etmesinde etkili olan
özellikleri belirlemek, çalışmamızın birincil amacıdır. Bu amaçla Konya
ölçeğinde Selçuk Üniversitesinde öğrenim gören yabancı uyruklu öğrencilerle
alan araştırması yapılmıştır. Araştırma neticesinde, yabancıların havayolu tercihinde
etkili olan en önemli özelliğin “güvenlik” olduğu bulgusuna ulaşılmıştır.
PENGEMBANGAN MEDIA PEMBELAJARAN TUTOR PAUD DALAM MENGGALI PERILAKU KERJASAMA ANAK USIA DINI MELALUI GERAK DAN LAGU
Authors: Widayati Tri 
Published: July 2018

Appropriate instructional media facilitates the teacher in improving the quality of teaching-learning process and the studentsâ€™learning achievment. This research aimed at developing learning media for the tutor of early childhood education to assist him/her to stimulate, develop, and evaluate cooperative behavior of the early age children through movements and songs. The procedures of media development covered need analysis, media development , evaluation and final product in the form of interactive CD. The result of this media development research indicates that the media of interactive CD produced can assist the tutor to stimulate and evaluate the cooperative behavior of early age children through movements and songs. The research findings also give some recommendations for further study.
BENTUK PERMAINAN YANG MEMOTIVASI ANAK LEPAS DARI ORANG TUA/PENGASUH DI KELOMPOK BERMAIN
Authors: Hapsari Melati Indri , Martono Heri 
Published: July 2018

Teacherâ€™s creativity in identifying and determining kinds of games appropriate to meet their childrenâ€™s needs is required to enable him/her to motivate them to be free from their parents or nurses. How to get the children free from their parents or nurses and to get them into the activitives in the playgroup become a problem for the teacher. This research assumed that this problem could be solved by selecting approprate games for the children. The purposes of this research were to identify the kinds of games and discover the appropriate ones to keep the children free from their parents. Exploring the facts in three play groups (Tunas Bangsa, BBC Kidâ€™s Center, and Anak Cerdas) in Semarang, the research discovered a number of games and the appropriate ones to motivate the children to join the activities in the play group. Based on the analysis, the research gave the teachers some recommendations in using the selected games.
Snapping at the Lateral Aspect of the Elbow
Authors: Feller Ross J. , Gil Joseph A. , DaSilva Manuel 
Published: July 2018

Case:
A 59-year-old man presented with snapping at the lateral aspect of the elbow and associated pain. Magnetic resonance imaging demonstrated extensor tendinopathy and thickening of the radial collateral ligament. Ultrasonography showed entrapment of a synovial fold in the radiohumeral joint. Initial arthroscopic debridement did not alleviate the snapping. Three months later, the patient underwent open excision of a thickened and partially torn annular ligament; subsequently, all of the symptoms resolved.

Conclusion:
Snapping elbow is a phenomenon that often coincides with pain and limited function. Accurate diagnosis is critical because misdiagnosis has been demonstrated to have serious consequences, including the need for repeat surgery.
Chronic Carpometacarpal Dislocation of the Thumb
Authors: McCarley Matthew , Foreman Mark 
Published: July 2018

Case:
We report a case of a chronic, irreducible carpometacarpal (CMC) dislocation of the thumb, which was managed with a trapeziometacarpal arthrodesis.

Conclusion:
This case demonstrates that arthrodesis is a suitable salvage procedure for chronic, irreducible CMC dislocations of the thumb.
Dorsal Radiocarpal Joint Fracture-Dislocation
Authors: Yang Paul R. , Patel Ankur D. , Esmail Adil N. 
Published: July 2018

Case:
A 19-year-old right-hand-dominant man sustained a right dorsal radiocarpal dislocation. He presented with instability secondary to displacement of the volar ligamentous structures and an avulsed fragment of the distal aspect of the radius within the radiocarpal articulation. The patient was treated with open reduction and internal fixation, as well as a capsuloligamentous repair. At the 18-month follow-up, he had no pain and excellent functional recovery.

Conclusion:
Our experience emphasizes the importance of looking critically at the radiographs when there is an irreducible radiocarpal fracture-dislocation. A volar distal radial fragment and attached ligamentous structures can be the main blocks to closed reduction.
Osteofibrous Dysplasia with Rhabdoid Elements in a 38-Year-Old Man with Spontaneous Regression Over Five Years
Authors: Exner G. Ulrich , von Hochstetter Arthur R. , Pfirrmann Christian W.A. 
Published: July 2018

Case:
A 38-year-old man presented with multifocal, partially confluent osteolytic lesions in the proximal dia-meta-epiphyseal region of the proximal aspect of the left tibia, which had been found incidentally when a radiograph was made after a rotational knee injury. When the results of a percutaneous core needle biopsy proved inconclusive, an open biopsy was performed. Osteofibrous dysplasia (OFD) with scattered groups of plump cells with a rhabdoid phenotype, shown to express both vimentin and pan-cytokeratin, was found. Because the lesion was an incidental finding, we decided to proceed with observation. Three months after the open biopsy, imaging showed marked regression of the lesion; there was nearly complete normalization 5 years later.

Conclusion:
To our knowledge, there has been only 1 prior reported case with these pathologic features, and there have been no reports of complete spontaneous regression in an adult patient with OFD. Treatment recommendations for OFD and for OFD-like adamantinoma range from observation to aggressive resection.