bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-Objective Optimization of Multistage Centrifugal Pump Based on Surrogate Model
Authors: Shuiguang Tong , Hang Zhao , Huiqin Liu , Yue Yu , Jinfu Li , Feiyun Cong 
Published: May 2019

Abstract
In this paper, the hydraulic efficiency optimization calculation method of a ten-stage centrifugal pump is researched. According to the hydraulic loss model, a multi-objective optimization calculation method based on surrogate models is proposed. In order to study the highly nonlinear relationship between key design variables and centrifugal pump external characteristic values, this paper builds the quadratic response surface, the radial basis Gaussian response surface, and Kriging three surrogate models using computer fluid dynamics (CFD) simulation analysis. Two types of calculation models (hydraulic loss model and three surrogate models) combined NSGA-Π genetic algorithm are applied to optimize the key design variables and to find the optimal solution of each model. The accuracy and effectiveness of the efficiency optimization methods based on the two types of calculation models are compared and analyzed. The results show that the calculation method of hydraulic loss model based on the semitheoretical and semi-empirical formula is less time-consuming but inaccurate. In contrast, the optimization method based on surrogate models using CFD simulation is accurate. What's more, comparing the surrogate models, the results based on the complete quadratic response surface model which make the efficiency of the first stage centrifugal pump reach 77.26% are more accurate.
Vegetation and habitat change in southern California through the Middle Miocene Climatic Optimum: Paleoenvironmental records from the Barstow Formation, Mojave Desert, USA
Authors: Loughney Katharine M. , Hren Michael T. , Smith Selena Y. , Pappas Janice L. 
Published: May 2019

AbstractThe Barstow Formation (ca. 19–13 Ma) of southern California, USA, is a terrestrial sequence known for its diverse Miocene mammalian faunas. The formation spans the Middle Miocene Climatic Optimum (MMCO; 17–14 Ma) and offers the opportunity to study environmental change during the last major interval of global warming of the Cenozoic. We combined isotopic analyses of carbon and hydrogen from sedimentary n-alkanes and bulk soil organic matter with analysis of phytoliths (plant silica) and diatoms to reconstruct vegetation composition, habitat structure, and moisture dynamics through the formation. The δ13C and δD of long-carbon-chain n-alkanes derived from terrestrial plants and preserved in sediments of the Barstow Formation record drying prior to the MMCO and through the Middle Miocene Climatic Transition (MMCT; beginning ca. 14 Ma), punctuated by increased moisture in fluvial environments during the peak of the MMCO. Variable isotopic results relate to changes in moisture, driven partly by facies, vegetation composition, tectonic activity, and climatic variability coinciding with intervals of high pCO2. Phytolith assemblages are dominated by forest indicators in riparian habitats during the MMCO, and grass morphotypes constitute significant components of phytolith assemblages after the MMCO, indicating a shift to drier, more open-canopy habitats. The establishment of dry, wooded grasslands in the Barstow Basin coincides with the beginning of the MMCT and cooling sea-surface temperatures in the Pacific Ocean. Our results indicate that moist, closed-canopy habitats formed in southern California during climatic warming, followed by savannah during climatic cooling and the shift to seasonal precipitation regimes.
Significance of dynamic contour tonometry in evaluation of progression of glaucoma in patients with a history of laser refractive surgery
Authors: Lee Sang Yeop , Kim Eun Woo , Choi Wungrak , Park Chan Keum , Kim Sangah , Bae Hyoung Won , Seong Gong Je , Kim Chan Yun 
Published: May 2019

AimsIn this study, we tested the hypothesis that intraocular pressure (IOP) parameters measured by dynamic contour tonometry (DCT) would be more relevant in progression of glaucoma when there is a history of laser refractive surgery (LRS) than the IOP parameters measured by Goldmann applanation tonometry (GAT) or calculated by correction formulae.MethodsNinety-eight eyes in 54 patients with open-angle glaucoma and a history of LRS were included in this retrospective study. IOP was measured by both GAT and DCT during follow-up. Baseline, mean, and peak IOP, IOP fluctuation, and IOP reduction were measured by each tonometry method. Corrected IOP parameters using central corneal thickness and mean keratometry values were also analysed. Clustered logistic regression was used to identify variables correlated with progression of glaucoma. Areas under the curve (AUCs) for correlated variables were also compared.ResultsThe mean DCT value (OR 1.36, p=0.024), peak DCT value (OR 1.19, p=0.02) and pattern SD (OR 1.10, p=0.016) were significant risk factors for progression. There was a significant difference in the predictive ability of the mean DCT and GAT values (AUC 0.63 and 0.514, respectively; p=0.01) and of the peak DCT and GAT values (0.646 and 0.503, respectively, p=0.009). The AUCs for corrected IOP did not exceed those of DCT.ConclusionsIOP measurements were more associated with progression of glaucoma when measurements were obtained by DCT than by GAT or correction formulae in eyes with a history of LRS.
Angiomatosis of the breast: a clinicopathological and immunophenotypical characterisation of seven cases
Authors: Ginter Paula S , McIntire Patrick J , Irshaid Lina , Liu Yi-Fang , Shin Sandra J 
Published: May 2019

AimsMammary angiomatosis is a rare, benign vascular lesion that morphologically mimics low-grade angiosarcoma (LGAS). To date, only occasional reports of this entity have been published, none of which included analysis by immunohistochemistry. The purpose of this study was to further characterise mammary angiomatosis by clinical, histological, and immunohistochemical means while emphasising distinguishing features from LGAS.MethodsSeven cases of primary mammary angiomatosis were evaluated. For one patient, a subsequent recurrence was also evaluated.ResultsAll patients were female with a median age at presentation of 51 years (range: 19–58 years). The most common clinical presentation was that of a palpable abnormality or mass (5/8) and the median primary tumour size was 3.1 cm (range: 2–9 cm). Of the six patients with follow-up, one developed a recurrence 6 years after initial presentation. Histologically, all cases were composed of variably sized ectatic, thin-walled vessels lined by flat normochromic endothelium diffusely infiltrating mammary stroma. Where present, lesional vessels infiltrated between and around terminal duct lobular units but not into individual intralobular stroma. Most cases (6/8) showed a combination of lymphatic-appearing and haemangiomatous-appearing vessels. Lymphatic-appearing vessels were D2-40 positive in all but one case. D2-40 was negative or weak in haemangiomatous-appearing vessels. All lesional vessels were CD31 positive. Ki-67 indices were <1% in all but one case (5%).ConclusionsMammary angiomatosis is a rare vascular lesion that shares clinical, morphological and immunohistochemical features with LGAS; however, certain key traits make the distinction possible.
Simultaneous R2*and quantitative susceptibility mapping measurement enables differentiation of thrombus hematocrit and age: an in vitro study at 3 T
Authors: Christiansen Spencer D , Liu Junmin , Boffa Michael B , Drangova Maria 
Published: May 2019

BackgroundThe efficacy of acute ischemic stroke treatment is affected by thrombus composition and age, yet no diagnostic method capable of quantitative thrombus characterization currently exists. This in vitro study evaluates the use of R2*, quantitative susceptibility mapping (QSM), and proton density fat fraction (FF) maps derived from a single gradient echo (GRE) MRI acquisition for characterizing clot of various hematocrit, as well as added calcified and lipidic components, throughout aging.MethodsTwo thrombus phantoms containing porcine clots (10–60% hematocrit, one with added calcium or lard) were scanned serially throughout 6 days of aging. Three-dimensional multi-echo GRE imaging was used to generate R2*, QSM, and FF maps, from which mean values for all clots at every time point were obtained. Receiver operating characteristic analysis was used to derive thresholds differentiating acute from chronic clot, and measured R2*and QSM were tested for their ability to estimate clot hematocrit.ResultsR2*and QSM varied minimally over the first 6 hours of aging (acute), and QSM was found to linearly relate to clot hematocrit. Beyond 6 hours (chronic), R2*and QSM increased considerably over time and hematocrit could be estimated from the R2*/QSM ratio. R2*and QSM thresholds of 22 s-1and 0.165 ppm differentiated acute from chronic clots with a sensitivity/specificity of 100%/100% and 85%/92%, respectively. QSM and FF maps definitively distinguished calcium and lipid, respectively, from clots of any hematocrit and age.ConclusionsR2*, QSM, and FF from a single multi-echo GRE scan discriminated hematocrit and age, and distinguished calcification and lipid withinin vitro clot.
Flow diversion beyond the circle of Willis: endovascular aneurysm treatment in peripheral cerebral arteries employing a novel low-profile flow diverting stent
Authors: Schob Stefan , Hoffmann Karl-Titus , Richter Cindy , Bhogal Pervinder , Köhlert Katharina , Planitzer Uwe , Ziganshyna Svitlana , Lindner Dirk , Scherlach Cordula , Nestler Ulf , Meixensberger Jürgen , Quäschling Ulf 
Published: May 2019

BackgroundFlow diversion (FD) has emerged as superior minimally invasive therapy for cerebral aneurysms. However, aneurysms of small peripheral vessel segments have not yet been adequately treatable. More specifically, currently established devices necessitate large microcatheters which impede atraumatic maneuvering. The Silk Vista Baby (SVB), a novel flow diverter, offers the as yet unique feature of deliverability via a 0.017 inch microcatheter. This study reports our first experience with the SVB in challenging intracranial vessels employing a vessel-specific tailored microcatheter strategy.Materials and methods25 patients (27 aneurysms) were prospectively included. A total of 30 SVBs were employed, predominantly targeting demanding aneurysms of the anterior communicating artery complex. The efficacy of the FD was assessed using two-dimensional vector-based perfusion and conventional digital subtraction angiography (DSA) after implantation and at the first follow-up at 3 months. The first follow-up was available in 22 patients.ResultsAll devices were implanted without technical or clinical complications. Eleven treatments were performed using the recommended Headway 17. In 14 interventions the even more maneuverable Excelsior SL10 was used, which was previously tried and tested for safety ’in vitro’ as an alternative delivery system. Aneurysmal influx was strongly reduced after implantation. All parent vessels remained patent. 17/27 aneurysms were completely occluded at first follow-up (∼2.7 months), 6/27 aneurysms showed decreased influx or delayed washout and one remained unchanged. In three cases follow-up DSAs are remaining.ConclusionsSVB provides enhanced controllability in vulnerable segments beyond the circle of Willis. Smaller variants (2.25 mm and 2.75 mm) can safely be implanted via the superiorly navigable Excelsior SL10. Hence, the SVB represents the next evolutionary step in minimally invasive treatment of cerebral aneurysms.
Clipping of recanalized intracerebral aneurysms initially treated by the Woven EndoBridge device
Authors: Pierot Laurent , Bannery Christophe , Batchinsky-Parrou Valery , Kleiber Jean-Charles , Soize Sebastien , Litre Claude Fabien 
Published: May 2019

Background and purposeIntrasaccular flow disruption using the Woven EndoBridge (WEB) is a safe and effective method to treat intracranial aneurysms, particularly wide neck bifurcation aneurysms. However mid term and long term follow-up imaging can show aneurysm remnant or recanalization, and retreatment is therefore sometimes necessary. In most cases, retreatment is performed using an endovascular approach. The present series reports and analyzes aneurysm clipping of recanalized or incompletely occluded aneurysms following WEB treatment.MethodsAll patients treated with the WEB device since the beginning of our experience in June 2011 were prospectively collected in a local database. Among them, patients who were retreated by clipping for aneurysm remnants were included in the present series.ResultsIn the cumulative population of 130 patients with aneurysms treated by the WEB device from June 2011 to February 2019, 4 patients (3.1%) were retreated with surgical clipping due to incomplete occlusion (2 patients) and aneurysm recanalization (2 patients). Three of the four aneurysms retreated (75%) were located in the middle cerebral artery and one in the anterior communicating artery (25.0%). The aneurysm was ruptured in 1 of 4 patients (25%). Clipping was performed 10–54 months after initial treatment with the WEB. Surgical exposure showed that the WEB device was inside the aneurysm sac in all cases. Clipping was easily performed in all but 1 case. Control DSA showed complete occlusion in two aneurysms and a neck remnant in two.ConclusionClipping is a feasible option for treating aneurysm remnants following initial treatment with intrasaccular flow disruption using the WEB.
Impella versus IABP in acute myocardial infarction complicated by cardiogenic shock
Authors: Alushi Brunilda , Douedari Andel , Froehlig Georg , Knie Wulf , Wurster Thomas H , Leistner David M , Staehli Barbara-Elisabeth , Mochmann Hans-Christian , Pieske Burkert , Landmesser Ulf , Krackhardt Florian , Skurk Carsten 
Published: May 2019

ObjectiveWe investigated the benefit of Impella, a modern percutaneous mechanical support (pMCS) device, versus former standard intra-aortic balloon pump (IABP) in acute myocardial infarction complicated by cardiogenic shock (AMICS).MethodsThis single-centre, retrospective study included patients with AMICS receiving pMCS with either Impella or IABP. Disease severity at baseline was assessed with the IABP-SHOCK II score. The primary outcome was all-cause mortality at 30 days. Secondary outcomes were parameters of shock severity at the early postimplantation phase. Adjusted Cox proportional hazards models identified independent predictors of the primary outcome.ResultsOf 116 included patients, 62 (53%) received Impella and 54 (47%)IABP. Despite similar baseline mortality risk (IABP-SHOCK II high-risk score of 18 % vs 20 %; p = 0.76), Impella significantly reduced the inotropic score (p < 0.001), lactate levels (p < 0.001) and SAPS II (p =0.02) and improved left ventricular ejection fraction (p = 0.01). All-cause mortality at 30 days was similar with Impella and IABP (52 % and 67 %, respectively; p = 0.13), but bleeding complications were more frequent in the Impella group (3 vs 4 units of transfused erythrocytes concentrates due to bleeding complications, p = 0.03). Previous cardiopulmonary resuscitation (HR 3.22, 95% CI 1.76 to 5.89; p < 0.01) and an estimated intermediate (HR 2.77, 95% CI 1.42 to 5.40; p < 0.01) and high (HR 4.32 95% CI 2.03 to 9.24; p = 0.01) IABP-SHOCK II score were independent predictors of all-cause mortality.ConclusionsIn patients with AMICS, haemodynamic support with the Impella device had no significant effect on 30-day mortality as compared with IABP. In these patients, large randomised trials are warranted to ascertain the effect of Impella on the outcome.
Impact of a ban on the open display of tobacco products in retail outlets on never smoking youth in the UK: findings from a repeat cross-sectional survey before, during and after implementation
Authors: Ford Allison , MacKintosh Anne Marie , Moodie Crawford , Kuipers Mirte A G , Hastings Gerard B , Bauld Linda 
Published: May 2019

BackgroundIn the UK, a ban on the open display of tobacco products at the point of sale (POS) was phased in between 2012 and 2015. We explored any impact of the ban on youth before, during and after implementation.MethodsA repeat cross-sectional in-home survey with young people aged 11–16 years old in the UK was conducted preban (2011, n=1373), mid-ban (2014, n=1205) and postban (2016, n=1213). The analysis focuses on the never-smokers in the sample (n=2953 in total). Preban, we quantified the associations of noticing cigarettes displayed at POS and cigarette brand awareness with smoking susceptibility. We measured any change in noticing cigarettes displayed at POS, cigarette brand awareness and smoking susceptibility between preban, mid-ban and postban. Postban, we assessed support for a display ban, perceived appeal of cigarettes and perceived acceptability of smoking as a result of closed displays.ResultsPreban, noticing cigarettes displayed at POS (adjusted OR [AOR]=1.97, 95% CI 1.30 to 2.98) and higher brand awareness (AOR=1.15, 95% CI 1.03 to 1.29) were positively associated with smoking susceptibility. The mean number of brands recalled declined from 0.97 preban to 0.69 postban (p<0.001). Smoking susceptibility decreased from 28% preban to 23% mid-ban and 18% postban (p for trend <0.001). Postban, 90% of never-smokers supported the display ban and indicated that it made cigarettes seem unappealing (77%) and made smoking seem unacceptable (87%).ConclusionsBoth partial and full implementation of a display ban were followed by a reduction in smoking susceptibility among adolescents, which may be driven by decreases in brand awareness.
Design of a centrifugal linear vibrating feeder driven by an eccentric motor
Authors: Niu Ruikun , Zhu Hua 
Published: May 2019

In this paper, a novel linear vibrating feeder is designed that uses the centrifugal motion of an eccentric motor as the driving source. First, the working principle of the linear vibrating feeder is theoretically analyzed and the dynamic model is established. Subsequently, a dynamic simulation of the system is carried out using ANSYS software. The relationship between the displacement amplitude, vibration speed, and frequency of the linear vibrating feeder prototype is tested using a three-dimensional vibrometer, with an OT-10A copper terminal used to test the prototype. The experimental results indicate that, at a vibration frequency of 125 Hz, maximum vibration speeds of 1.23 and 1.70 mm/s are reached in the X- and Z-directions, respectively. The corresponding maximum amplitudes are 0.7 and 0.99 mm, and the material feeding speed reaches a maximum value of 123 mm/s. Compared with similar piezoelectric and electromagnetic vibrating feeders, the total weight of the prototype is reduced by a third, the noise is reduced by more than 20 dB, and the driving voltage is only 3.6 V. Hence, the performance of the linear vibrating feeder has been successfully demonstrated.
Investigation of the microstructural, mechanical, and thermal evolution of dissimilar aluminium alloys during friction stir welding
Authors: Kasirajan T. , Ravindran R. , Ramkumar T. , Selvakumar M. 
Published: May 2019

This work deals with the joining of 6 mm thick dissimilar aluminium plates (AA5083-H111 and AA6082-T6) using a friction stir welding method and by varying the process parameters. Test experiments were performed to identify the influence of process parameters on the joint efficiency of the weldments. The process parameters such as tool rotation speed and tool pin profile were varied; whereas, tool travel speed, tilt angle, and axial force were kept constant for all weldments. Microstructure evaluation was carried out using light optical and scanning electron microscopes, which exposed the grain refinement in the nugget zone (NZ) and thermo-mechanical affected zone (TMAZ). Mechanical property tests for tensile strength, hardness, and bending were performed to understand the influence of the parameters over the weldments. Heat development between the tool shoulder and workpiece was analyzed by calculating the heat flow and heat flux. The thermal diffusivity of AA5083-H111 and AA6082-T6 were calculated to understand the influence of heat distribution in the joint efficiency of the weldments. It is inferred from the current study that the threaded cylinder tool at a rotational speed of 900 rpm achieved the highest tensile strength, hardness, and bend strength over the combination of other parameters.
Molecular Residual Disease and Adjuvant Trial Design in Solid Tumors
Authors: Coakley Maria , Garcia-Murillas Isaac , Turner Nicholas C. 
Published: May 2019

Abstract
Advances in diagnosis and treatment have resulted in a high rate of survival for many patients with early-stage cancers. However, identifying who is at ongoing risk of relapse remains of high priority to direct subsequent adjuvant therapy. Multiple recent retrospective studies have shown that detection of tumor-derived materials in blood, in particular with circulating tumor DNA (ctDNA) analysis, can identify patients with residual disease before clinical or radiological evidence of metastatic disease, anticipating relapse with relatively high sensitivity and high specificity. We discuss how these emerging technologies are defining new subgroups of patients with “Molecular Residual Disease” and “Molecular Relapse.” We outline how novel clinical trials in the adjuvant setting designed for these new subgroups of patients may improve selection for adjuvant therapies, and provide new surrogate endpoints that may allow for early registration of adjuvant therapies and novel clinical trial designs in the adjuvant setting. We discuss the current limitations of these techniques and the routes to clinical implementation.
Activation of PPARγ in Myeloid Cells Promotes Progression of Epithelial Lung Tumors through TGFβ1
Authors: Sippel Trisha R. , Johnson Amber M. , Li Howard Y. , Hanson Dwight , Nguyen Teresa T. , Bullock Bonnie L. , Poczobutt Joanna M. , Kwak Jeff W. , Kleczko Emily K. , Weiser-Evans Mary C. , Nemenoff Raphael A. 
Published: May 2019

Abstract

Lung cancer is a heterogeneous disease in which patient-specific treatments are desirable and the development of targeted therapies has been effective. Although mutations in KRAS are frequent in lung adenocarcinoma, there are currently no targeted agents against KRAS. Using a mouse lung adenocarcinoma cell line with a Kras mutation (CMT167), we previously showed that PPARγ activation in lung cancer cells inhibits cell growth in vitro yet promotes tumor progression when activated in myeloid cells of the tumor microenvironment. Here, we report that PPARγ activation in myeloid cells promotes the production of TGFβ1, which, in turn, acts on CMT167 cancer cells to increase migration and induce an epithelial–mesenchymal transition (EMT). Targeting TGFβ1 signaling in CMT167 cells prevented their growth and metastasis in vivo. Similarly, another mouse lung adenocarcinoma cell line with a Kras mutation, LLC, induced TGFβ1 in myeloid cells through PPARγ activation. However, LLC cells are more mesenchymal and did not undergo EMT in response to TGFβ1, nor did LLC require TGFβ1 signaling for metastasis in vivo. Converting CMT167 cells to a mesenchymal phenotype through overexpression of ZEB1 made them unresponsive to TGFβ1 receptor inhibition. The ability of TGFβ1 to induce EMT in lung tumors may represent a critical process in cancer progression. We propose that TGFβ receptor inhibition could provide an additional treatment option for KRAS-mutant epithelial lung tumors.
Implications: This study suggests that TGFβ receptor inhibitors may be an effective therapy in a subset of KRAS-mutant patients with non–small cell lung cancer, which show an epithelial phenotype.