bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gamma-Glutamyl Transferase-to-Platelet Ratio as a Novel Predictor of Long-Term Adverse Outcomes in Patients after Undergoing Percutaneous Coronary Intervention: A Retrospective Cohort Study
Authors: Zheng Ying-Ying , Wu Ting-Ting , Chen You , Hou Xian-Geng , Yang Yi , Ma Xiang , Ma Yi-Tong , Zhang Jin-Ying , Xie Xiang 
Published: March 2019

Background Gamma-glutamyl transferase (GGT) has been shown to be involved in the pathogenesis of both coronary artery disease (CAD) and liver disease, and it has been reported that the GGT-to-platelet ratio (GPR) is an independent predictor for adverse outcomes from liver fibrosis and hepatic carcinoma. However, the relation between the GPR and adverse outcomes in CAD patients after percutaneous coronary intervention (PCI) has not been investigated.
Methods A total of 5,636 patients enrolled in Clinical Outcomes and Risk Factors of Patients with Coronary Heart Disease after PCI, a retrospective cohort study, from January 2008 to December 2016, were divided into two groups according to GPR (GPR < 0.12, n = 2,769 and GPR ≥ 0.12, n = 2,867). The primary outcome was long-term mortality including all-cause mortality (ACM) and cardiac mortality (CM) after PCI. The average follow-up time was 35.9 ± 22.6 months.
Results We found that there were significant differences between the two groups in the incidences of ACM (p = 0.011), CM (p = 0.001), major adverse cardiovascular events (MACEs, p < 0.024), major adverse cardiovascular and cerebrovascular events (MACCEs, p = 0.014) and bleeding events (p = 0.003). Multivariate Cox regression analyses showed that GPR was an independent predictor for ACM (hazard ratio [HR]: 1.536 [95% confidence interval [CI]:1.162–2.032], p = 0.003), CM (HR: 1.763 [95% CI: 1.283–2.424], p < 0.001), MACCEs (HR: 1.269 [95% CI: 1.066–1.511], p = 0.007) and MACEs (HR: 1.308 [95% CI: 1.089–1.570], p = 0.004) in stable CAD patients but that it was an independent predictor for only the incidence of bleeding events (HR: 3.104 [95% CI: 1.680–5.736], p < 0.001) in acute coronary syndrome (ACS) patients.
Conclusion This study indicates that GPR is an independent and novel predictor of adverse long-term outcomes in CAD patients who underwent PCI.
Scalp Reconstruction after Malignant Tumor Resection: An Analysis and Algorithm
Authors: Ehrl Denis , Brueggemann Alexandra , Broer P. Niclas , Koban Konstantin , Giunta Riccardo , Thon Niklas 
Published: March 2019

Abstract
Background An oncologic tumor resection of the scalp can result in complex wounds that result in challenging scalp reconstructions. This study aimed to evaluate the outcomes of microvascular-based scalp reconstructions (MSR) in oncologic patients and to propose an algorithmic treatment approach.
Methods Within a 5-year period, 38 patients having undergone 41 MSR (15 anterolateral thigh (ALT), 15 gracilis muscle (GM), and 11 latissimus dorsi muscle (LDM) flaps) after extensive scalp tumor resections fulfilled inclusion criteria for this study.
Results Malignant skin disease included superficial and/or deep infiltration of the calvarium in 26 and combined intracranial infiltration in 12 patients. In case of bone replacement (24 patients), MSR was done concomitant, otherwise MSR was performed after pathological confirmation of tumor-free margins. LDM flaps were used in cases with defect sizes of 400 to 1250cm2, whereas ALT- and GM flaps were chosen for defects ranging from 40 to 350cm2. The average length of the pedicle was comparable in ALT- and LDM flaps and longer than in GM flaps. Total flap loss with need for revision surgery and minor donor site morbidity occurred in four and three patients, respectively.
Conclusion Microsurgical reconstruction of moderate-to-extensive scalp defects remains a reliable method with overall low risks and satisfactory aesthetic results, while, according to our experience, muscle flaps show the best functional and aesthetic results. However, in cases of central scalp defects and in situations when a long vascular pedicle of the flap is important, the ALT flap seems to be the best solution.
Endovascular Treatment of Aorta-Iliac Aneurysms with a Flared Iliac Limb
Authors: Balezantis Tomas , Duvnjak Stevo 
Published: March 2019

Endovascular abdominal aneurysm repair (EVAR) relies on the quality of the proximal and distal landing zone. Reinterventions are higher in patients with suboptimal landing zone. The study aimed to evaluate reintervention rate after endovascular treatment of an aorta-iliac aneurysm using the flared iliac limbs.The retrospective study included 179 patients treated with EVAR at a single university hospital institution from January 2011 to January 2014 of which 75 patients (42%) were treated with flared iliac limb stent graft and 104 patients (58%) were treated with a nonflared iliac limb stent graft. There were 165 male patients (92%), mean age was 75.8 ± 6.6 years.Thirty-six patients underwent secondary treatment accounting for overall reintervention rate of 20%. Endoleak type 1b occurred in 13 patients (7%), followed by endoleak type 1a in six patients (3%). Endoleak type 2 occurred in seven patients (4%) requiring the treatment due to abdominal aortic aneurysm (AAA) enlargement, endoleak type 3 in three patients (2%), and leg stent graft thrombosis in seven patients (4%). In 143 patients (80%), there were no secondary interventions during the follow-up period. Reintervention due to endoleak type 1b was statistically significantly higher in a flared iliac limb group (p < 0.02) with the rate of 7.2% compared with 1.9% rate in nonflared iliac limb group. The mean follow-up was 44.3 ± 20.4. Overall mortality was 33%.Flared iliac limb with a distal diameter of ≥ 20 mm, show a higher rate of iliac limb reintervention in a follow-up period due to endoleak type 1b.
Domain topology, stability, and translation speed determine mechanical force generation on the ribosome
Authors: Leininger Sarah E. , Trovato Fabio , Nissley Daniel A. , O’Brien Edward P. 
Published: March 2019

Significance
Mechanochemistry, the influence of molecular-scale mechanical forces on chemical processes, can occur on actively translating ribosomes through the force-generating actions of motor proteins and the cotranslational folding of domains. Such forces are transmitted to the ribosome’s catalytic core and alter rates of protein synthesis, representing a form of mechanical allosteric communication. These changes in translation–elongation kinetics are biologically important because they can influence protein structure, function, and localization within a cell. Many fundamental questions are unresolved concerning the properties of protein domains that determine mechanical force generation; the effect of translation speed on this force; and exactly how, at the molecular level, force is generated. In this study we answer these questions using molecular simulations and statistical mechanical modeling.
Spatiotemporal coupling of attosecond pulses
Authors: Wikmark Hampus , Guo Chen , Vogelsang Jan , Smorenburg Peter W. , Coudert-Alteirac Hélène , Lahl Jan , Peschel Jasper , Rudawski Piotr , Dacasa Hugo , Carlström Stefanos , Maclot Sylvain , Gaarde Mette B. , Johnsson Per , Arnold Cord L. , L’Huillier Anne 
Published: March 2019

Significance
In most optics textbooks, one writes the electric field describing an optical wave as a product of temporal and spatial amplitudes. This approximation often breaks down for short optical pulses. An example of such spatiotemporal coupling is chromatic aberrations, where the focal properties of the radiation vary with frequency over the pulse bandwidth. In this work, we point out significant chromatic aberrations of attosecond pulses, which depend on the geometry of the generation process. These aberrations are intrinsic to the generation process and need to be eliminated in applications requiring attosecond pulses to be focused over a small region.
Disrupting information alters the behavioral response to a mutual signal trait in both sexes of Nicrophorus (Coleoptera: Silphidae) burying beetles
Authors: Wormington Jillian D , Luttbeg Barney 
Published: March 2019

AbstractEffective signals transfer information in a way that enhances the fitness of the sender. Signal traits are often sexually dimorphic. However, in some species, males and females display similar signals, and these mutual signals are less often studied. Competition for resources occurs in both males and females, and mate choice is likely to occur whenever mates vary in quality and reproductive investment is high. Nicrophorus burying beetles compete intrasexually over the carrion resources on which they biparentally raise their young. Nicrophorus species also often have clypeal membranes which scale hyperallometrically with body size, exaggerating the apparent body size of larger individuals. To examine the potential signaling function of clypeal membranes, we examined the behavioral responses of male and female Nicrophorus orbicollis and Nicrophorus pustulatus burying beetles to same- and opposite-sex social partners which had their membranes painted black or clear. We found evidence that blocking the information in clypeal membranes affected intrasexual aggressive interactions for both sexes of both species. Blocking a female’s signal reduced the likelihood of mating attempts for male N. pustulatus, whereas blocking a male’s signal influenced female rejection behaviors in N. orbicollis. Our results show that males and females can experience similar selection pressures, and suggest that examining mutual signals in a broader range of systems will expand our understanding of evolutionary differences and similarities between the sexes.
Conformity in the collective: differences in hunger affect individual and group behavior in a shoaling fish
Authors: Wilson Alexander D M , Burns Alicia L J , Crosato Emanuele , Lizier Joseph , Prokopenko Mikhail , Schaerf Timothy M , Ward Ashley J W 
Published: March 2019

Abstract
Animal groups are often composed of individuals that vary according to behavioral, morphological, and internal state parameters. Understanding the importance of such individual-level heterogeneity to the establishment and maintenance of coherent group responses is of fundamental interest in collective behavior. We examined the influence of hunger on the individual and collective behavior of groups of shoaling fish, x-ray tetras (Pristella maxillaris). Fish were assigned to one of two nutritional states, satiated or hungry, and then allocated to 5 treatments that represented different ratios of satiated to hungry individuals (8 hungry, 8 satiated, 4:4 hungry:satiated, 2:6 hungry:satiated, 6:2 hungry:satiated). Our data show that groups with a greater proportion of hungry fish swam faster and exhibited greater nearest neighbor distances. Within groups, however, there was no difference in the swimming speeds of hungry versus well-fed fish, suggesting that group members conform and adapt their swimming speed according to the overall composition of the group. We also found significant differences in mean group transfer entropy, suggesting stronger patterns of information flow in groups comprising all, or a majority of, hungry individuals. In contrast, we did not observe differences in polarization, a measure of group alignment, within groups across treatments. Taken together these results demonstrate that the nutritional state of animals within social groups impacts both individual and group behavior, and that members of heterogenous groups can adapt their behavior to facilitate coherent collective motion.
The Attentional Blink is Related to the Microsaccade Rate Signature
Authors: Roberts Mark J , Lange Gesa , Van Der Veen Tracey , Lowet Eric , De Weerd Peter 
Published: March 2019

Abstract
The reduced detectability of a target T2 following discrimination of a preceding target T1 in the attentional blink (AB) paradigm is classically interpreted as a consequence of reduced attention to T2 due to attentional allocation to T1. Here, we investigated whether AB was related to changes in microsaccade rate (MSR). We found a pronounced MSR signature following T1 onset, characterized by MSR suppression from 200 to 328 ms and enhancement from 380 to 568 ms. Across participants, the magnitude of the MSR suppression correlated with the AB effect such that low T2 detectability corresponded to reduced MSR. However, in the same task, T1 error trials coincided with the presence of microsaccades. We discuss this apparent paradox in terms of known neurophysiological correlates of MS whereby cortical excitability is suppressed both during the microsaccade and MSR suppression, in accordance to poor T1 performance with microsaccade occurrence and poor T2 performance with microsaccade absence. Our data suggest a novel low-level mechanism contributing to AB characterized by reduced MSR, thought to cause suppressed visual cortex excitability. This opens the question of whether attention mediates T2 performance suppression independently from MSR, and if not, how attention interacts with MSR to produce the T2 performance suppression.
Baseline Chest Computed Tomography for Early Diagnosis of Invasive Pulmonary Aspergillosis in Hemato-oncological Patients: A Prospective Cohort Study
Authors: Bitterman Roni , Hardak Emilia , Raines Marina , Stern Anat , Zuckerman Tzila , Ofran Yishai , Lavi Noa , Guralnik Luda , Frisch Avraham , Nudelman Olga , Paul Mical , Oren Ilana 
Published: March 2019

Abstract
Invasive pulmonary aspergillosis (IPA) has dire consequences in hemato-oncological patients. We report our experience with performing routine baseline chest computed tomography for early diagnosis of IPA. We found high rates of proven or probable IPA diagnosed on admission among patients with newly diagnosed acute myeloid leukemia.
The Origins of Peter’s Pence
Authors: Naismith Rory , Tinti Francesca 
Published: March 2019

Abstract
Peter’s Pence began as an annual donation from England to the papacy. It was later taken up more widely and lasted until the Reformation in England, but its beginnings are much murkier. This article reassesses the earliest forms of Peter’s Pence in the period before 1066. Offerings made by individual Anglo-Saxon pilgrims to Rome gave rise to more regular gifts from several kings between Offa (757–96) and Alfred (871–99); under the latter, gifts also began to be associated with the people as well as the king. A fully articulated mechanism for raising Peter’s Pence only emerges later, however, in the time of Edgar (959–75) and his successors, especially Æthelred II (978–1016). The nature of the national and local frameworks which were used to extract, channel and safeguard the render are assessed in detail, based on sources from across England. Bishops played a central role in this system, above all the archbishop of Canterbury, who received the collected tribute from the kingdom as a whole. The article, utilising a variety of chronicles, law codes and religious texts, as well as coins, stresses the significance of the emergence of Peter’s Pence for views of late Anglo-Saxon England’s government and religious ideology. Comparisons with gifts to Rome from post-Conquest England and from other parts of early medieval Europe underscore the uniqueness of Anglo-Saxon England’s large and regular offering—a powerful reflection of its close and ongoing relationship with St Peter and his heirs.
Maternal and perinatal outcomes of asylum seekers and undocumented migrants in Europe: a systematic review
Authors: Gieles Noor C , Tankink Julia B , van Midde Myrthe , Düker Johannes , van der Lans Peggy , Wessels Catherina M , Bloemenkamp Kitty W M , Bonsel Gouke , van den Akker Thomas , Goosen Simone , Rijken Marcus J , Browne Joyce L 
Published: March 2019

AbstractBackgroundAsylum seekers (AS) and undocumented migrants (UM) are at risk of adverse pregnancy outcomes due to adverse health determinants and compromised maternal healthcare access and service quality. Considering recent migratory patterns and the absence of a robust overview, a systematic review was conducted on maternal and perinatal outcomes in AS and UM in Europe.MethodsSystematic literature searches were performed in MEDLINE and EMBASE (until 1 May 2017), complemented by a grey literature search (until 1 June 2017). Primary research articles reporting on any maternal or perinatal outcome, published between 2007 and 2017 in English/Dutch were eligible for inclusion. Review protocols were registered on Prospero: CRD42017062375 and CRD42017062477. Due to heterogeneity in study populations and outcomes, results were synthesized narratively.ResultsOf 4652 peer-reviewed articles and 145 grey literature sources screened, 11 were included from 4 European countries. Several studies reported adverse outcomes including higher maternal mortality (AS), severe acute maternal morbidity (AS), preterm birth (UM) and low birthweight (UM). Risk of bias was generally acceptable, although the limited number and quality of some studies preclude definite conclusions.ConclusionLimited evidence is available on pregnancy outcomes in AS and UM in Europe. The adverse outcomes reported imply that removing barriers to high-quality maternal care should be a priority. More research focussing on migrant subpopulations, considering potential risk factors such as ethnicity and legal status, is needed to guide policy and optimize care.
Individual trophic specialization in juvenile European seabass: implications for the management of a commercially important species
Authors: Cobain Matthew R D , Steward Will , Trueman Clive N , Jensen Antony 
Published: March 2019

Abstract
Individual differences in diet can play an important role defining a population's ecological niche and its role within food webs and habitats, but individual trophic specialization is rarely considered in a fisheries context. Stocks of European seabass, Dicentrarchus labrax, have declined in recent years, and policy has focused on managing fishing effort. Inshore nursery grounds represent a critical habitat in terms of recruitment to standing stocks, and improved understanding of the ecology of juvenile seabass at the level of the individual may assist the development of management strategies aimed at maximizing their survival and growth. We quantified levels of individual trophic specialization in juvenile seabass using stomach contents and stable isotope analyses at a monthly resolution over an annual cycle. We found significant, seasonally varying levels of individual specialization in stomach contents, with reduced specialization observed in the spring. This was corroborated by stable isotope analyses, where isotopic variance among seabass individuals was significantly higher compared to that in two other concurrently sampled, sympatric bentho-pelagic predators. Our findings suggest that juvenile seabass form trophic-generalist populations composed of specialized individuals. Considering variation in individual behaviours may improve management strategies aimed at protecting the vulnerable life stages of this commercially important species.
Rethinking the Legality of Intervention by Invitation: Toward Neutrality
Authors: Nguyen Quoc Tan Trung 
Published: March 2019

Abstract
The article re-examines one of the most established and classical doctrines in international law, with a massive body of literature—intervention by invitation. The doctrine is straightforward and intuitive, and therefore compelling. Since the use of force or intervention in the domestic affairs of a state is prohibited, the consent of the ‘state’ itself could, naturally, eliminate the wrongfulness of the act. There is contention that the ‘government-preference’ principle of intervention by invitation affords a ‘clear alternative’ to external intervention authorized by the Security Council (‘UNSC’)[ Wippman (1996, Duke Journal of Comparative & International Law, 7, 209)]. Others, however, stressing the momentous nature of current events, believe that ‘democratic legitimacy’ is fundamental. The present author finds both approaches inadequate. In many cases, the complexity of intervention by invitation in both cases is, inevitably, reduced to the issue of recognition: ‘Who can speak for a state?’[We can see such tendency in many works on the topic such as: 2016, Byrne, Journal on the Use of Force and International Law, 3, 97, 100; Wippman (1996, Duke Journal of Comparative & International Law, 7, 217–22; Oppenheim and Lauterpacht, International Law, 7th edition (Longmans Green 1952), 249; or Fox, ‘Intervention by Invitation’ in Weller M (ed), The Oxford Handbook of the Use of Force in International Law (Oxford University Press 2015), 831–35.]. The latter is a highly political question. The law, then, is left undetermined, and actions are explained by the government’s political preferences and its rhetorical appeal to so-called international community values [Falk (ed), The International Law of Civil War (The John Hopkins Press 1971), 28]. Inspired by general neutrality approach, the author will evoke available theoretical principles and state practices to form a theory of the Equality of internal actors, (hereinafter ‘Equality theory’), in the hope of proving the relevance, reliability, consistency and overall superiority of this theory in dealing with the legality of intervention by invitation.
Two pathways for spermatogenesis in Sinanodonta woodiana (Lea, 1834) (Bivalvia: Unionidae)
Authors: Labecka Anna Maria , Domagala Jozef 
Published: March 2019

AbstractThe Chinese pond mussel, Sinanodonta woodiana, an invasive species indigenous to Asia, naturally colonizes new locations as a glochidium that parasitizes fish. Human activity has facilitated a continental-scale spread of S. woodiana in Europe, where it is found in artificial reservoirs and has begun to invade natural habitats. This study aimed to investigate the reproductive activity of males in a female-biased population of S. woodiana that lives in a riverine channel linked to a power plant with a cooling water system in NW Poland. Cells formed during spermatogenesis and morphological changes in reproductive follicles (acini) were analysed over a 2-year period using light microscopy. Typical and atypical spermatogenic pathways were identified. The atypical spermatozoa were released from multinucleated cysts and had significantly shorter heads than typical spermatozoa. Spermatozoa formed in the typical way occurred consistently in all months over the study period, while the atypical spermatozoa were recorded occasionally in the first year of the study and more frequently in the second study. The highest proportion of males with spent gonads was found in late summer and early autumn. Our data show that mussels produce spermatozoa year-round, but that the levels of typical and atypical spermatogenesis varied. The two pathways of spermatogenesis in S. woodiana provide an important insight into potential mechanisms underlying the evolution of doubly uniparental inheritance of mitochondrial DNA, a phenomenon observed in S. woodiana. Additionally, a detailed understanding of the reproductive cycle of this non-native species can help to understand its reproductive potential and predict the likely direction of population change in a newly colonized area. The breeding population of S. woodiana studied by us inhabits a tributary of the Odra River, one of Poland’s largest rivers, and thus poses a threat to the natural environment. Riverine habitats like our study site are local heat islands and the mussels reproducing in them over time may colonize natural waters and expand the range of their distribution.