bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Analysis of a Small Size Printed UWB Monopole Antenna with Quad Band Notch functionality using Dual Number of TVDS EBG Cell
Authors: Samanta Aditya Kumar , Mandal Tapan , Dey Rajesh , Singh Monika , Mahajan Rupali Atul 
Published: November 2024

Abstract

A small size microstrip fed ultra-wide bandwidth (UWB) antenna with quad band notch characteristics has been described in this paper. Band notch characteristics are achieved by loading dual number of two via double-slot type electromagnetic band gap (TVDS EBG) structures. The size of TVDS - EBG structure is less compared to other conventional EBG cells. Detailed parametric study, surface current distributions, input impedance and equivalent circuit model has been conducted to elucidate the operational mechanisms underlying notch band in the proposed antenna. The proposed antenna design has been put into practical use and measurement outcomes are portrayed to compare against simulation results that notable align well. Proposed design provides impedance matching from 2.91 to 11.62 GHz (for 2 ≤ VSWR) with successful suppression of WiMAX (3.300–3.700 GHz), WLAN (4.910–5.350 GHz, and 5.630–5.820 GHz) and X-band ITU (8.03–8.50 GHz). The measured far-field radiation patterns are stable and group delay is almost constant in the whole operating frequency band. Thus the compact antenna might be an excellent candidate for UWB utilization..
Quinoa Protein Hydrolysate as Potential Immunomodulators: Effects on Cytokine Production and Macrophage Activation
Authors: Rueda Julio , Lobo Manuel Oscar , Galdeano Carolina Maldonado , Samman Norma Cristina 
Published: November 2024

Abstract

The increasing demand for plant-based proteins, particularly quinoa (Chenopodium quinoa Willd.), has spotlighted its potential as a functional food ingredient due to its high-quality protein content and bioactive compounds and a range of health-promoting properties, including antioxidant, anti-inflammatory, and immunomodulatory effects. This study investigates the immunomodulatory potential of quinoa protein concentrate (QPC), quinoa protein hydrolysate (QPH), and a quinoa peptide fraction (QPF < 3kDa) in regulating cytokine production and activating macrophages. QPH was prepared via QPC alcalase hydrolysis, followed by ultrafiltration (QPF < 3 kDa). In vitro and ex vivo assays on BALB/c mice peritoneal and spleen macrophages were conducted to evaluate cytotoxicity, cytokine profiles induced (Interleukin (IL)-6, IL-10, Tumor Necrosis Factor (TNF)-α, Interferon (IFN)-γ), and phagocytic activity of macrophages. Results indicated that QPC and QPH showed no cytotoxic effects at protein concentrations ≤ 1000 µg/mL. QPH at1000 µg/mL increased the production of IFN-γ and TNF-α, while increasing IL-10 release, suggesting a balanced pro- and anti-inflammatory response. Furthermore, QPF significantly enhanced phagocytic activity in spleen macrophages, underscoring its role in systemic immune activation. These findings suggest quinoa-derived proteins and peptides hold promise as functional ingredients for immune health applications.
Early developmental milestones associated with tics and psychopathological comorbidity : An EMTICS study
Authors: Steinberg Tamar , Feldman-Sadeh Dana , Apter Alan , Bronstein Yael , Elfer Noa , Carmel Miri , Michaelovsky Elena , Weizman Avi , Nahon Matan , Horesh Danny , Morer Astrid , Delgar Blanca Garcia , Schrag Anette , Fennig Silvana , Hoekstra Pieter J. , Dietrich Andrea , Benaroya-Milshtein Noa 
Published: November 2024

Abstract

Background
Chronic Tic disorders (CTD) including Tourette Syndrome (TS), are associated with psychopathological comorbidities. Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and other comorbidities have been linked to delays in early developmental milestones. Few studies have investigated the relationship between early developmental milestones, tic severity, and related comorbidities.
Methods
383 participants aged 3–16 years (76.8%, n = 294 boys) with CTD from the baseline assessment of the European Multicenter Tics in Children Study (EMTICS), were evaluated for early developmental milestones (sitting, walking, first words, complete a sentence, bladder and bowel control), tic severity, tic-related functional impairment, obsessive-compulsive disorder (OCD), ADHD, oppositional defiant disorder (ODD) and suspected ASD. Data was collected using gold-standard self and clinician reporting instruments. Analyses included Pearson correlations and logistic regressions.
Results
Correlations between the acquisition of developmental milestones and tic severity or impairment were significant with small effect sizes (severity of motor tics and tic impairment were correlated with walking (r = .11), while vocal tics were correlated with first words (r = .12)). Logistic regression revealed that delayed acquisition of first words was significantly associated with ADHD, ODD and suspected ASD (Odds Ratio (ROR): 1-1.13, 1.05–1.21, 1.01–1.16, 1.04–1.22, respectively), while delayed walking acquisition was associated with OCD (ROR: 1.01–1.27).
Discussion
This study highlights the association between early developmental milestones and later psychopathological comorbidities in CTD patients. These findings emphasize the need for further research to distinguish between children with only tics and those with tics and psychopathological comorbidities, to improve early detection of individuals at risk.
Faecalibacterium Prausnitzii Extracellular Vesicles Regulating Macrophage Differentiation via Homologous Recombination Repair in Inflammatory Bowel Disease
Authors: Pan Yinya , Zhao Xinlu , Chen Qiongyun , Zhao Tao , Ma Yichun , Wu Hai , Xiang Ying , Jiang Ping , Li Wenjun , Yan Qiong , Mao Shangtao , Tao Yufei , wang Lei , Zhu Yun , Xu Guifang 
Published: November 2024

Abstract

Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation influenced by the depletion of beneficial gut microbiota, a critical factor in disease onset and progression. This study investigates the therapeutic potential of extracellular vesicles (EVs) derived from Faecalibacterium prausnitzii (F.p EVs), a commensal bacterium whose reduction is linked to IBD. Our research demonstrates that F.p EVs are preferentially taken up by macrophages, where they exert their anti-inflammatory effects through the enhancement of homologous recombination (HR) repair mechanisms. Specifically, F.p EVs upregulate the expression of key proteins involved in HR repair, such as BRCA1 and BRCA2, thereby reducing DNA damage and inhibiting the cGAS-STING pathway, which is central to the inflammatory response. This modulation of macrophage function results in decreased pro-inflammatory cytokine production and enhanced intestinal barrier integrity. By elucidating these mechanisms, our study provides a clear understanding of how F.p EVs can be used to target fundamental aspects of IBD pathology, laying the groundwork for the development of more effective and targeted therapies.
Decomposing the net fiscal position of migrants in Europe
Authors: Boffi Giacomo , Suari-Andreu Eduard , Vliet Olaf van 
Published: November 2024

Abstract

In this study, we are the first to employ the Oaxaca-Blinder decomposition to analyse the difference between the net fiscal positions of migrants and native-born individuals in 15 EU countries from 2007 to 2018. We combine EU-SILC cross-sectional data on individual background characteristics, personal income, and welfare benefits with OECD information on personal income taxes and social security contributions. Our findings reveal crucial determinants of the direct fiscal gap between migrants and natives. To varying degrees, age, education, and country effects are the largest contributors to the observed differential between the net fiscal positions of natives (more negative) and migrants (more positive). We observe important differences between intra-EU and extra-EU migrants. More specifically, education has a significant positive effect on the net fiscal position of intra-EU migrants, while it is nearly irrelevant for extra-EU migrants. By shedding light on the factors explaining differences in the net fiscal impact, our study offers valuable insights for policymakers aiming to design interventions to foster inclusivity and reduce inequality between migrants and natives in Europe.
Repurposing Doxycycline for the Inhibition of Monkeypox Virus DNA Polymerase: A Comprehensive Computational Study
Authors: Yousaf Muhammad Abrar , Michel Maurice , Khan Abeedha Tu-Allah , Noreen Misbah , Bano Saddia 
Published: November 2024

Abstract

The global spread of monkeypox, caused by the double-stranded DNA monkeypox virus (MPXV), has underscored the urgent need for effective antiviral treatments. In this study, we aim to identify a potent inhibitor for MPXV DNA polymerase (DNAP), a critical enzyme in the virus replication process. Using a computational drug repurposing approach, we performed a virtual screening of 1,615 FDA-approved drugs based on drug-likeness and molecular docking against DNAP. Among these, 1,430 compounds met Lipinski's rule of five for drug-likeness, with Doxycycline emerging as the most promising competitive inhibitor, binding strongly to the DNAP active site with a binding affinity of − 9.3 kcal/mol. This interaction involved significant hydrogen bonds, electrostatic interactions, and hydrophobic contacts, with Doxycycline demonstrating a stronger affinity than established antivirals for smallpox, including Cidofovir, Brincidofovir, and Tecovirimat. Stability and flexibility analyses through a 200 ns molecular dynamics simulation and normal mode analysis confirmed the robustness of Doxycycline binding to DNAP. Overall, our results suggest Doxycycline as a promising candidate for monkeypox treatment, though additional experimental and clinical studies are needed to confirm its therapeutic potential and clinical utility.
Lymphocyte levels in Crohn's disease patients in clinical remission are significantly lower than normal people
Authors: He Asi , Hu Tulan , Li Linzhen 
Published: November 2024

Abstract

Background and purpose
Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory bowel disease caused by multiple causes. Lymphocytes migration is involved in the pathogenesis of IBD. The purpose of this study was to evaluate whether there were differences in blood lymphocytes levels between IBD patients in clinical remission and normal people.
Patients and Methods:
A total of 94 Crohn's disease (CD) and 20 ulcerative colitis (UC) patients were included in this study. Ninety-four people who underwent physical examination in our hospital were randomly selected as controls. We analyzed whether there were differences in white blood cell count, neutrophil count, neutrophil percentage, lymphocyte count, lymphocyte percentage between CD patients, UC patients and normal people.
Results
There were significant differences in lymphocyte count (P<0.001), lymphocyte percentage (P<0.001) and neutrophil count (P = 0.038), neutrophil percentage (P<0.001) between CD patients and normal people, but no statistically significant differences in sex (P = 0.216), age (P = 0.745) and white blood cell count (P = 0.757). UC patients had significant differences in white blood cell count (P = 0.005), lymphocyte count (P = 0.010) and neutrophil count (P = 0.023), but no difference in lymphocyte percentage (P = 0.968) and neutrophil percentage (P = 0.461).
Conclusions
The white blood cell count of CD patients was not significantly different from that of normal people, but the lymphocyte count and lymphocyte percentage were significantly different from that of normal people. Similar results were not found in UC patients.
Posterior Alien Hand Syndrome in a Patient with Parieto-Occipital Infarction: A Rare Presentation Mimicking Anterior Variant Features
Authors: Elhaj Ammar , Abdalla Hadeel A.S , Elhassan Islam , Elhassan Mohamed , Mohamed Saga 
Published: November 2024

Abstract

Background
Alien hand syndrome (AHS) is a rare condition characterized by involuntary movements of a limb that the patient perceives as alien and is usually associated with anterior or posterior brain lesions. This case involved a unique posterior AHS overlapping with the anterior form.
Case Presentation:
A 76-year-old male patient presented to the emergency department with confusion agitation and involuntary movement of the right arm subsequent to a fall. His medical history included recurrent pulmonary embolism treated with edoxaban, diabetes, and hypertension. Initial CT imaging indicated chronic changes; nevertheless, within 24 hours, his symptoms intensified, and subsequent imaging demonstrated a left posterior circulation infarct (PCA). His uncontrollable arm movements resulted in a diagnosis of posterior alien hand syndrome (AHS).
Management and outcome:
Management involved the use of aspirin, temporary cessation of edoxaban, and agitation management with quetiapine. After confirming the stability of the infarction, edoxaban was reintroduced. This case underscores the difficulties in treating AHS and anticoagulation in a complicated stroke scenario.
Conclusion
This case underscores the varied manifestations of AHS variations, indicating a complicated interaction among anatomical regions. A multidisciplinary approach is crucial for the management of AHS, especially in instances with overlapping features.
Features of management of patients with seasonal allergic rhinitis
Authors: Vladimirova T. Yu. , Martynova A. B. 
Published: November 2024

Introduction. Seasonal allergic rhinitis continues to be one of the most common chronic diseases, affecting up to 24% of the adult population of the Russian Federation.Aim. To evaluate the effectiveness of the drug mometasone furoate (Nozefrin Allergy) in patients with seasonal allergic rhinitis in outpatient practice.Materials and methods. The study was conducted in a group of 42 patients aged 18 to 73 years (average age 39.0 ± 15.5 years) diagnosed with seasonal allergic rhinitis. All patients received monotherapy with Nozefrin Allergy, 2 injections (50 mcg of mometasone furoate each) into each nostril once a day for 30 days. The effectiveness of the treatment was determined on the 7th, 14th, 30th day of treatment and on the 60th day.Results and discussion. During the use of the drug Nozefrin Allergy, by the 7th day there was a significant decrease in complaints of impaired smell by 3.6 times, sneezing by 2.4 times, discharge from the nasal cavity decreased by 2.3 times, and nasal congestion by 2.3 times. 2.1 times. After 14 days, nasal congestion disappeared in 64.3%, nasal discharge and itching in the nasal cavity were absent in 69.0% and 88.1% of patients. According to the SST-12 test, already by the 7th day of using the drug Nozefrin Allergy, there was an increase in the average total score to 10.1 ± 1.9 points, which corresponds to normosmia. At days 14, 30, and 60, the mean total SST-12 score remained stable at 10.6 ± 0.9 points, 10.9 ± 1.1 points, and 11.1 ± 0.5 points, respectively. The dynamics of respiratory function at the end of the course of treatment was characterized by an improvementin the total volumetric flow to 783.4 ± 162.7 cm3/s and a decrease in nasal resistance to 0.2 ± 0.1 cPa/ml. The total rTNSS scale score by the 7th day decreased to 9.1 ± 0.4 points, the severity of the assessed complaints was moderate.Conclusion. The data obtained indicate the effectiveness of using the drug Nozefrin Allergy in patients with seasonal allergic rhinitis in outpatient clinical practice.
Development and Refinement of a Chatbot for Birthing Individuals and Newborn Caregivers: Mixed Methods Study
Authors: Rivera Rivera Jessica Nathalie , AuBuchon Katarina E , Smith Marjanna , Starling Claire , Ganacias Karen G , Danielson Aimee , Patchen Loral , Rethy Janine A , Blumenthal H Joseph , Thomas Angela D , Arem Hannah 
Published: November 2024

Background
The 42 days after delivery (“fourth trimester”) are a high-risk period for birthing individuals and newborns, especially those who are racially and ethnically marginalized due to structural racism.

Objective
To fill a gap in the critical “fourth trimester,” we developed 2 ruled-based chatbots—one for birthing individuals and one for newborn caregivers—that provided trusted information about postbirth warning signs and newborn care and connected patients with health care providers.

Methods
A total of 4370 individuals received the newborn chatbot outreach between September 1, 2022, and December 31, 2023, and 3497 individuals received the postpartum chatbot outreach between November 16, 2022, and December 31, 2023. We conducted surveys and interviews in English and Spanish to understand the acceptability and usability of the chatbot and identify areas for improvement. We sampled from hospital discharge lists that distributed the chatbot, stratified by prenatal care location, age, type of insurance, and racial and ethnic group. We analyzed quantitative results using descriptive analyses in SPSS (IBM Corp) and qualitative results using deductive coding in Dedoose (SocioCultural Research Consultants).

Results
Overall, 2748 (63%) individuals opened the newborn chatbot messaging, and 2244 (64%) individuals opened the postpartum chatbot messaging. A total of 100 patients engaged with the chatbot and provided survey feedback; of those, 40% (n=40) identified as Black, 27% (n=27) identified as Hispanic/Latina, and 18% (n=18) completed the survey in Spanish. Payer distribution was 55% (n=55) for individuals with public insurance, 39% (n=39) for those with commercial insurance, and 2% (n=2) for uninsured individuals. The majority of surveyed participants indicated that chatbot messaging was timely and easy to use (n=80, 80%) and found the reminders to schedule the newborn visit (n=59, 59%) and postpartum visit (n=66, 66%) useful. Across 23 interviews (n=14, 61% Black; n=4, 17% Hispanic/Latina; n=2, 9% in Spanish; n=11, 48% public insurance), 78% (n=18) of interviewees engaged with the chatbot. Interviewees provided positive feedback on usability and content and recommendations for improving the outreach messages.

Conclusions
Chatbots are a promising strategy to reach birthing individuals and newborn caregivers with information about postpartum recovery and newborn care, but intentional outreach and engagement strategies are needed to optimize interaction. Future work should measure the chatbot’s impact on health outcomes and reduce disparities.
استخدام كتاب فتح المعين بطريقة المناقشة لترقية مهارة القراءة بالمعهد العصري إنصاف الدين بندا أتشيه
Authors: Ridha Muhammad , Ninoersy Tarmizi , Harizi Hasvi 
Published: November 2024

اعتمادا على الملاحظة الأولى التي قام بها الباحث أن الطلبة للمرحلة العالية بالمعهد العصري إنصاف الدين بند أتشيه، أكثرهم يفهمون القواعد لكن لم يقدروا تطبيقها، ويحفظون المفردات لكن لم يفهموا النصوص العربية ومضمونها، وقد تظهر الملل من بعض الطلبة، بأن تكون أفكارهم خارجة عن الاهتمام بعملية التعليم والتعلم في حجرة الدراسة. بهذه المشكلة، يريد الباحث أن يعالجها من خلال استخدام كتاب فتح المعين بطريقة المناقشة لترقية مهارة القراءة. يهدف هذا البحث للتعرف على كيفية استخدام كتاب فتح المعين بطريقة المناقشة لترقية مهارة القراءة بالمعهد العصري إنصاف الدين بند أتشيه، وللتعرف على فعالية استخدام كتاب فتح المعين بطريقة المناقشة لترقية مهارة القراءة بالمعهد العصري إنصاف الدين بند أتشيه. في هذا البحث، يستخدم الباحث منهج البحث التجريبي بنوع One Group Pre-Test Post Test Design، يقدم الباحث ورقة الملاحظة المباشرة والاختبار القبلي والاختبار البعدي كأدوات البحث. ونتائج البحث تدل أن استخدام كتاب فتح المعين بطريقة المناقشة في تدريس مهارة القراءة بالمعهد إنصاف الدين تحصل على درجة ممتازة، في أنشطة المعلم بالدرجة 91،67%، وفي أنشطة الطالبات بالدرجة 86،67%، عند تحليل بيانات الملاحظة المباشرة. وإن استخدام كتاب فتح المعين بطريقة المناقشة يكون فعالا لترقية مهارة القراءة، ويعتمد الباحث على أن نتيجة من الاختبار ( (Paired Sample T-Test تحصل على النتيجة مستوى الدلالة (Sig. 2-tailed 0,000)، وهي أصغر من نتيجة مستوى الدلالة ((0,05، تدل على أن الفرض الصفري مردود والفرض البديل مقبول. فتشير أن استخدام كتاب فتح بطريقة المناقشة يكون فعالا لترقية مهارة القراءة.
A CIRCULAÇÃO DE OBRAS DE EXPRESSÃO ALEMÃ NO RIO DE JANEIRO DO SÉCULO XIX
Authors: Larissa de Assumpção  
Published: November 2024

Este texto tem como objetivo trazer um breve panorama sobre as obras de ficção de expressão alemã que circularam no Rio de Janeiro do século XIX, de forma a contribuir para as investigações sobre a História do Livro e sobre a circulação de romances estrangeiros no território brasileiro. Para isso, foram utilizados como fonte os cadernos da infância do imperador Pedro II que fazem parte do acervo do Museu Imperial de Petrópolis, os catálogos da Biblioteca Imperial (1903), da Biblioteca Fluminense (1866) e do Gabinete Português de Leitura (1906) e os catálogos publicados pelos livreiros Eduardo e Henrique Laemmert e por Baptiste-Louis Garnier entre as décadas de 1830 e 1870. A análise é centrada em três pontos principais: o contexto da circulação de impressos entre a Europa e o Brasil no século XIX; a presença de obras de ficção de expressão alemã no catálogo da biblioteca imperial e nos cadernos de Pedro II e as menções a autores e livros de expressão alemã em catálogos dos irmãos Laemmert e de Garnier. Ao final do texto, conclui-se que alguns romances de autores alemães chegaram à capital do império brasileiro – especialmente por meio de traduções feitas a partir do francês – e circularam tanto entre a aristocracia quanto entre o público leitor mais amplo, que poderia entrar em contato com eles por meio de livrarias ou do acervo de bibliotecas públicas.
Objetos digitais Fair
Authors: Dias Guilherme Ataide , Klenia Rodrigues Bandeira Lucilene , Lemos dos Anjos Renata 
Published: November 2024

Essa investigação tem como objetivo desvendar e discutir as principais características dos objetos digitais FAIR. Esses artefatos apresentam-se como uma solução contemporânea para a otimização da gestão de dados de pesquisa. A implementação dos objetos digitais FAIR encontram-se em processo de desenvolvimento pela comunidade científica, porém já se apresenta como uma alternativa viável para atender às demandas emergentes associadas com a gestão de grandes volumes de dados, caracterizados pela heterogeneidade e diversas granularidades. Destacam-se, ademais, as demandas que as novas ferramentas de inteligência artificial podem impor ao contexto da gestão de dados de pesquisa. A pesquisa empreendida é classificada como exploratória, bibliográfica e de cunho qualitativo. A obtenção de informações acerca dos objetos digitais FAIR foi realizada através de pesquisas no Portal de Periódicos da CAPES, do Google Scholar e visitas aos sites canônicos relacionados ao tema investigado. Com base nas análises efetuadas, conclui-se que os objetos digitais FAIR representam uma possibilidade factível para abordar a complexidade na gestão de dados de pesquisa. Os conceitos e tecnologias subjacentes aos objetos digitais FAIR podem contribuir para o desenvolvimento de outras pesquisas na área da Ciência da Informação.