bluuebunny/crossref_metadata_2025_split huggingface dataset:
Instabilities in multiplanet circumbinary systems
Authors: Sutherland Adam P , Kratter Kaitlin M 
Published: June 2019

ABSTRACT
The majority of the discovered transiting circumbinary planets are located very near the innermost stable orbits permitted, raising questions about the origins of planets in such perturbed environments. Most favoured formation scenarios invoke formation at larger distances and subsequent migration to their current locations. Disc-driven planet migration in multiplanet systems is likely to trap planets in mean motion resonances and drive planets inwards into regions of larger dynamical perturbations from the binary. We demonstrate how planet–planet resonances can interact with the binary through secular forcing and mean-motion resonances, driving chaos in the system. We show how this chaos will shape the architecture of circumbinary systems, with specific applications to Kepler 47 and the Pluto–Charon system, limiting maximum possible stable eccentricities and indicating what resonances are likely to exist. We are also able to constrain the minimum migration rates of resonant circumbinary planets.
A far-UV survey of three hot, metal-polluted white dwarf stars: WD0455−282, WD0621−376, and WD2211−495
Authors: Preval Simon P , Barstow Martin A , Bainbridge Matthew , Reindl Nicole , Ayres Thomas , Holberg Jay B , Barrow John D , Lee Chung-Chi , Webb John K , Hu Jiting 
Published: June 2019

ABSTRACT
Using newly obtained high-resolution data (R ∼ 1 × 105) from the Hubble Space Telescope, and archival UV data from the Far Ultraviolet Spectroscopic Explorer, we have conducted a detailed UV survey of the three hot, metal-polluted white dwarfs WD0455−282, WD0621−376, and WD2211−495. Using bespoke model atmospheres, we measured Teff, log g, and photospheric abundances for these stars. In conjunction with data from Gaia, we measured masses, radii, and gravitational redshift velocities for our sample of objects. We compared the measured photospheric abundances with those predicted by radiative levitation theory, and found that the observed Si abundances in all three white dwarfs, and the observed Fe abundances in WD0621−376 and WD2211−495, were larger than those predicted by an order of magnitude. These findings imply not only an external origin for the metals, but also ongoing accretion, as the metals not supported by radiative levitation would sink on extremely short time-scales. We measured the radial velocities of several absorption features along the line of sight to the three objects in our sample, allowing us to determine the velocities of the photospheric and interstellar components along the line of sight for each star. Interestingly, we made detections of circumstellar absorption along the line of sight to WD0455−282 with three velocity components. To our knowledge, this is the first such detection of multicomponent circumstellar absorption along the line of sight to a white dwarf.
Does Conducting a Risk Assessment Facilitate Better Care for Patients at Risk of Pressure Injuries?
Authors: Hödl Manuela , Eglseer Doris , Lohrmann Christa 
Published: June 2019

ABSTRACT

OBJECTIVE
To evaluate if the use of a pressure injury (PI) risk assessment is associated with the more frequent use of international evidence-based guideline interventions in patients at risk of PI.

METHODS
Data were collected through a multicenter cross-sectional prevalence study conducted on November 14, 2017. Study authors analyzed data from 532 patients 65 years at risk of PI or older in Austrian hospitals.

MAIN OUTCOME MEASURES
Repositioning, mobilization, floating heels/heel devices, moisture/barrier cream, patient education, malnutrition screening, referral to a dietitian, and hydration/nutrition management.

MAIN RESULTS
The risk assessment was documented on admission for 80% (n = 435) of the at-risk patients. Patients for whom a PI risk assessment was conducted were older and more care dependent, and nearly 20% had a PI compared with patients for whom no risk assessment was conducted upon admission. Conducting a risk assessment led to a statistically significantly higher number of internationally recommended PI preventive interventions being performed for at-risk patients, such as provision of moisture/barrier cream, mobilization specific for PI, malnutrition screening, and floating heels or heel suspension devices.

CONCLUSIONS
These results showed that conducting and documenting a risk assessment led to more recommended interventions being performed. Although such interventions are recommended for all patients, these findings are especially relevant for patients at mild or moderate risk of PI who might be otherwise overlooked, which in turn could reduce hospital-acquired PI rates.
Meta-analysis of Histological Margin Positivity in the Prediction of Recurrence After Crohn’s Resection
Authors: Ryan Jessica M. , Rogers Ailín C. , O’Toole Aoibhlinn , Burke John P. 
Published: June 2019

BACKGROUND:
Despite significant advances in the medical management of Crohn’s disease, many patients will require intestinal resection during their lifetime. It is disappointing that many will also develop disease recurrence.

OBJECTIVES:
The current study utilizes meta-analytical techniques to determine the effect of positive histological margins at the time of index resection on disease recurrence.

DATA SOURCES:
Embase, Medline, PubMed, PubMed Central, and Cochrane databases were searched using a Boolean search algorithm for articles published up to August 2017.

STUDY SELECTION:
Meta-analysis was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

MAIN OUTCOME MEASURES:
Databases were searched for studies reporting the outcomes for patients with Crohn’s disease undergoing primary resection that correlated resection margin status with disease recurrence. Results were reported as pooled ORs with 95% CI.

RESULTS:
A total of 176 citations were reviewed; 18 studies comprising 1833 patients were ultimately included in the analysis, with a mean rate of histopathological margin positivity of 41.7 ± 17.4% and a pooled mean follow-up of 69 ± 39 months. Histopathological margin positivity was associated with a higher rate of overall recurrence (OR, 1.7; 95% CI, 1.3–2.1; p < 0.001), clinical recurrence (OR, 1.7; 95% CI, 1.0–2.8; p = 0.04), and anastomotic recurrence (OR, 1.6; 95% CI, 1.0–2.3; p = 0.03). In studies reporting plexitis specifically at the resection margin, there was an increase in recurrence (OR, 2.3; 95% CI, 1.1–4.9; p = 0.02).

LIMITATIONS:
The definitions of histological margin positivity and postoperative recurrence vary between the studies and follow-up durations vary.

CONCLUSIONS:
The presence of involved histological margins at the time of index resection in Crohn’s disease is associated with recurrence, and plexitis shows promise as a marker of more aggressive disease. Further studies with homogeneity of histopathological and recurrence reporting are required.
Impact of Electronic Chromoendoscopy on Adenoma Miss Rates During Colonoscopy: A Systematic Review and Meta-analysis
Authors: Desai Madhav , Viswanathan Lavanya , Gupta Neil , Kennedy Kevin F. , Repici Alessandro , Hassan Cesare , Sharma Prateek 
Published: June 2019

BACKGROUND:
The impact of virtual chromoendoscopy such as narrow-band imaging, Fujinon intelligent chromoendoscopy, blue-light imaging, linked-color imaging, and i-SCAN on adenoma detection rate has been variable. However, adenoma miss rate (another measure suggested as a quality indicator) of electronic chromoendoscopy modalities has not been systematically evaluated.

OBJECTIVES:
This study aimed to perform a systematic review and meta-analysis to examine the adenoma miss rate of white-light endoscopy compared with electronic chromoendoscopy.

DATA SOURCES:
Medline, Embase, Scopus, Web of Knowledge, and Cochrane were the data sources for this study.

STUDY SELECTION:
The studies selected were tandem randomized controlled trials of electronic chromoendoscopy modalities compared with white-light endoscopy.

INTERVENTIONS:
Electronic chromoendoscopy compared with white light endoscopy was used to measure the adenoma miss rate.

MAIN OUTCOME MEASURES:
Primary outcome was the pooled adenoma miss rate of electronic chromoendoscopy techniques compared with white-light endoscopy. Secondary outcomes were subgroup analysis, adenoma size analysis, and adenoma detection rate.

RESULTS:
A total of 3507 patients were evaluated from 7 eligible tandem randomized control trials. A total of 1423 patients had white-light endoscopy as the first of the tandem examinations. The rest of the patients had electronic chromoendoscopy as the first of the tandem examination (narrow-band imaging, 988 patients; Fujinon intelligent chromoendoscopy, 728 patients; i-SCAN, 233 patients; blue-light imaging, 64 patients; and linked-color imaging, 71 patients). The pooled adenoma miss rate for electronic chromoendoscopy was not different than white-light endoscopy (17.9% vs 21%; OR, 0.72 (0.67–1.11); I
2 67%; p = 0.13). When only narrow-band imaging, blue-light imaging, and linked-color imaging were considered, the pooled rate was statistically significant (OR, 0.60 (0.37–0.98); p = 0.04). The pooled adenoma detection rate was not statistically different with electronic chromoendoscopy than white-light endoscopy (OR, 1.02 (0.88–1.19); p = 0.78).

LIMITATIONS:
The small number of studies to assess the impact of each modality limited stratified conclusions.

CONCLUSIONS:
Electronic chromoendoscopy is not associated with a significant reduction in adenoma miss rate compared with white-light colonoscopy.
Effect of Antiplatelet Drugs on D-Dimer Levels: A Systematic Review and Meta-analysis
Authors: Morelli Francesca , Schol-Gelok Suzanne , Arends Lidia R. , Boersma Eric , Kruip Marieke J. H. A. , Versmissen Jorie , van Gelder Teun 
Published: June 2019

Aims:
D-dimer is a product of fibrinolysis. In clinical practice, D-dimer levels are commonly used to rule out venous thromboembolism. Antiplatelet drugs may influence D-dimer levels, potentially affecting the accuracy of this diagnostic tool. To evaluate the effect of antiplatelet drugs on D-dimer levels, we performed a systematic review and meta-analysis of all published articles on this topic (PROSPERO registration number CRD42017058932).

Methods and Results:
We electronically searched EMBASE, MEDLINE Epub, Cochrane, Web of Science, and Google Scholar (100 top relevance) (last search on October 5, 2017). We included randomized controlled trials, cohort studies, and cross-sectional studies conducted in humans, with a drug exposure time of at least 7 days. Two reviewers independently selected eligible articles and extracted the data. Five controlled trials, 7 cohort studies, and 5 cross-sectional studies were finally included. Meta-analysis involving all 1117 participants showed no change in dimer levels (standardized mean difference: −0.015, 95% confidence interval, 0.182–0.151, P = 0.855).

Conclusions:
In conclusion, antiplatelet drugs do not seem to influence D-dimer levels.
Puerarin Decreases Collagen Secretion in AngII-Induced Atrial Fibroblasts Through Inhibiting Autophagy Via the JNK–Akt–mTOR Signaling Pathway
Authors: Xu Xudong , Jiang Ruhong , Chen Mengmeng , Dong Mengmeng , Liu Qiang , Cheng Hui , Zhou Kuangshi , Chen Laite , Li Miaomiao , Jiang Chenyang 
Published: June 2019

Abstract:
Puerarin is used to treat cardiovascular diseases due to its anti-inflammatory and antifibrotic effects. However, its mechanism of action in atrial fibroblasts is unknown. In this study, we investigated the autophagy pathway and molecular changes in angiotensin II (AngII)-stimulated atrial fibroblasts in response to puerarin treatment. Atrial fibroblasts were cultured and then subjected to stimulation with AngII and puerarin or other chemical drugs (3-MA, CQ, and SP600125). Quantitative real-time polymerase chain reaction and Western blot experiments were used to quantify the expression levels of mRNA and protein. mCherry-GFP-LC3 adenovirus was applied to reflect the autophagic flux. The results showed aggravating levels of autophagy and collagen deposit in the presence of AngII. Puerarin inhibited autophagy and decreased collagen secretion in a dose-dependent manner in atrial fibroblasts. Furthermore, phosphorylation of JNK was down-regulated in response to puerarin, whereas phosphorylation of Akt and mammalian target of rapamycin (mTOR) was upregulated. Interestingly, reduced autophagy and collagen secretion were observed when the JNK signaling pathway was blocked using SP600125. We also observed upregulation of Akt and mTOR phosphorylation in the presence of SP600125. These results suggest that puerarin exerts its antifibrotic effect in atrial fibroblasts partly through the inhibition of autophagy. Furthermore, the mechanism of action of puerarin in fibroblast autophagy seems to be mediated partly through JNK–Akt–mTOR signaling.
Double Tongue Flaps for Anterior Huge Palatal Fistula Closure
Authors: Zhou Xia , Ma Lian 
Published: June 2019

Summary:
Even though it is widely accepted that the tongue flap is effective and feasible for repair of huge palatal fistula, there still exist a few failed cases due to the severity or complicated situation. The aim of this paper is to report the validity and feasibility of using double tongue dorsal flaps to repair a huge anterior fistula. A 10-year-old boy diagnosed with Van de Woude syndrome with repaired bilateral cleft lip and palate presented with a huge anterior fistula divided by septum. A double tongue dorsal flap was designed to cover the fistula. The huge unusual anterior palatal fistula was repaired successfully by usage of double pedicle tongue flaps with a follow-up period of 1 month. The double tongue flap is an alternative choice to handle a large residual fistula in anterior part of palate which was divided into 2 fistulas by septum. This technique was indicated in the situation of large residual fistula in anterior part of palate which was divided into 2 fistulas by septum after bilateral cleft palate repair.
NLRP2 inflammasome in dorsal root ganglion as a novel molecular platform that produces inflammatory pain hypersensitivity
Authors: Matsuoka Yutaka , Yamashita Ayahiro , Matsuda Megumi , Kawai Kenshiro , Sawa Teiji , Amaya Fumimasa 
Published: June 2019

Abstract
Inflammatory pain hypersensitivity is associated with activation of primary afferent neurons. This study investigated the existence of the inflammasome in dorsal root ganglion (DRG) and the functional significance in the development of inflammatory pain hypersensitivity. Tissue inflammation was induced in male C57BL/6 mice with complete Freund's adjuvant (CFA) or ceramide injection into the hind paw. Behavioral testing was performed to investigate inflammation-induced pain hypersensitivity. Ipsilateral L5 DRGs were obtained for analysis. Expression of nucleotide oligomerization domain-like receptors (NLRs) was analyzed with real-time PCR. Cleaved interleukin (IL)-1β and NLRP2 expression was investigated with immunohistochemistry and western blotting. Caspase 1 activity was also measured. A caspase 1 inhibitor and NLRP2 siRNA were intrathecally administered to inhibit NLRP2 inflammasome signaling in DRG. Cleaved IL-1β expression was significantly increased after CFA injection in small-sized DRG neurons. The amount of cleaved IL-1β and caspase 1 activity were also increased. Among several NLRs, NLRP2 mRNA was significantly increased in DRG after CFA injection. NLRP2 was expressed in small-sized DRG neurons. Intrathecal injection of a caspase 1 inhibitor or NLRP2 siRNA reduced CFA-induced pain hypersensitivity and cleaved IL-1β expression in DRG. Induction of cleaved IL-1β and NLRP2 in DRG neurons was similarly observed after ceramide injection. NLRP2 siRNA inhibited ceramide-induced pain hypersensitivity. These results confirmed the existence of NLRP2 inflammasome in DRG neurons. Activation of the NLRP2 inflammasome leads to activation of DRG neurons and subsequent development of pain hypersensitivity in various types of tissue inflammation.
Relationship Between Lifestyle and Family Functioning Among Family Members of Amphetamine Abusers in Southeast Iran
Authors: Izadabadi Zahra , Tirgari Batool , Pouraboli Batool 
Published: June 2019

Abstract

Introduction:
Drug abuse is a social event and one of the worse health problems in the current age. Nowadays, the inclination of young people has changed from traditional drugs to more sophisticated and industrial drugs such as ecstasy, glass, and crack. Increasing drug abuse can be sought in families’ lifestyles as an effective factor on individuals’ health. The disturbance in family functioning can be associated with an individual’s antisocial behaviors like addiction. Therefore, the current study is aimed at determining the relationship between lifestyle and family functioning of family members of patients with amphetamine abuse who referred to drug rehabilitation clinics in Southeast Iran.

Method:
This is a correlational descriptive study conducted on 196 family members of patients with amphetamine abuse who referred to drug rehabilitation clinics in Southeast Iran. Data were collected through the use of demographic, family functioning, and lifestyle questionnaires. Data analysis was performed with SPSS 19 using independent t test, one-way analysis of variance, and Pearson correlation coefficient test.

Results:
The total mean score of lifestyle was observed to be 105.77 ± 24.39. Among the dimensions of lifestyle, the highest mean score was associated with health responsibility (26.28 ± 7.43), whereas the lowest mean score was associated with exercise (12.7 ± 5.1). In addition, the results showed that the total mean score of family functioning was 129.25 ± 20.97. Among the dimensions of family functioning, the highest mean score was associated with general functioning (26.07 ± 4.92), whereas the lowest mean score was associated with affective responsiveness (13.16 ± 2.88). There was a positive and significant relationship between lifestyle and family functioning, such that the increase in the mean score of lifestyle increased the score of family functioning (r = .34, p = .001).

Conclusion:
Because lifestyle is associated with family functioning of patients with amphetamine abuse, basic measures can be taken in families to prevent addiction by increasing information to families, which enhances their lifestyle and functioning.
Exploring the Trajectory and Prevention of Alcohol Use Among Young People From the Perspective of Professional Youth Workers
Authors: Haglund Kristin , Hayter Mark 
Published: June 2019

Abstract
Excessive alcohol use is a significant health issue. Underage drinking is one expression of excessive alcohol use. Researchers have identified a trajectory of alcohol involvement. Gaps exist in understanding the influences that delay and promote the trajectory of alcohol use among young people. The purpose of this study was to explore the contexts and influences that limited and contributed to the trajectory of alcohol use among young people. A qualitative descriptive design was used. Eight youth workers from a city in Northern England participated in individual audio-recorded semistructured interviews. Transcriptions were coded. Data were analyzed within, and across, codes to identify themes. The theme “Alcohol is an Expected Part of Life” characterized a hypothetical trajectory of alcohol involvement. “Fostering Community in Youth Centers” characterized how participants’ perceptions informed their work. The results increase understanding of how contexts may influence initiation, promotion, and prevention of alcohol use among young people.
Systematic review and meta-analysis of the prevalence and mortality of metallo-beta-lactamases in Iranian patients infected with metallo-beta-lactamase-producing Pseudomonas aeruginosa
Authors: Mohammadpour Bashir , Salimizand Himen , Rahmani Khaled 
Published: June 2019

Background and adjective:

Pseudomonas aeruginosa is associated with morality and healthcare associated infections. P. aeruginosa producing metallo-beta-lactamase (MBL) genes causing more problems especially in patients with underlying immunosuppressive background. The aim of this study is a systematic review and meta-analysis of the prevalence of MBLs in P. aeruginosa in Iranian patients.

Search method:
All available national and international databanks (PubMed, Science Direct and pages web address) were searched to find published studies from 2006 to March 2018. Quality of studies was assessed by STROBE. Because of the significant heterogeneity, random effects model was used to combine the results. Statistical analysis was performed by STATA (software version 13, Stanford, California, USA) (confidence interval; 95%, P < 0.05).

Findings:
Final analyze was done on 51 articles relevant with 7548 sample size. Current study indicates that most of the P. aeruginosa isolated from wound. Pooled prevalence belonged to genes bla
VIM-1 3%, bla
VIM-2 2%, bla
IMP-1 5% and bla
IMP-2 3% in infected patients. Overall prevalence of another MBLs is replaced in Table 1. The overall prevalence of the MBL genes in all regions of Iran were 16% (95% confidence interval, 0.15–0.17). Moreover, the mortality rate in MBL producing P. aeruginosa infected patients, was 6% in three studies.

Conclusion:
The bla
VIM-1, bla
IMP, bla
IMP-1 and bla
IMP-2 genes are more prevalent in Iranian patients. Therefore, it is essential to set a national surveillance program for preventing of antibiotic resistance in Iranian patient.
Innovation in Nursing Leadership: A Skill That Can Be Learned
Authors: Machon Michelle , Cundy Denise , Case Helen 
Published: June 2019

Innovation and creativity are part of everyday life for the bedside nurse. Nursing clinicians continuously innovate and create to meet each patient's unique needs. However, policies, regulations, and drama can inhibit that creativity when clinicians move into management. Three nurse leaders discuss their journeys to bring innovation into their leadership practices through participation in a yearlong program, the “Executive Fellowship in Innovation Health Leadership.”
The authors share insights gained after they participated in a cohort of health care leaders who took part in this yearlong fellowship. Details of the fellowship program are discussed, along with the benefits of entering such a program. Three separate innovation projects are reviewed. In Iowa, an Assistant Vice President of Nursing led the restructure and development of a support role to remove unnecessary tasks from nurse managers. In California, a Director of Education, Practice, and Informatics took a personal journey to enhance her senior leadership skills. In Florida, a Chief Nursing Officer created a program designed to teach nurse leaders to be innovative in health care. Each author addresses the innovation model/methodologies that they applied in the execution of their individual projects.