bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimierung und Klinische Entscheidungsunterstützung
Authors: Sager Sebastian 
Published: September 2018

Zusammenfassung
Mediziner müssen täglich viele wichtige Entscheidungen treffen. Ein klinisches Beispiel ist die Planung und
Dosierung einer Chemotherapie. Ein zweites Beispiel ist die Unterscheidung zwischen verschiedenen
Herzrhythmusstörungen basierend auf EKG-Daten. Das notwendige (oftmals unbewusste) Expertenwissen
ist nicht leicht transferierbar und beispielsweise im ländlichen Raum nicht immer verfügbar. Wir erläutern,
wie durch eine Kombination von Mathematik, modelliertem Expertenwissen und klinischen Daten
neuartige automatisierte Systeme zur Entscheidungsunterstützung entstehen.
A short history of written Wu, Part II: Written Shanghainese
Authors: Snow Don , Senyao Shen , Xiayun Zhou 
Published: September 2018

AbstractThe recent publication of the novelMagnificent Flowers(Fan Hua繁花) has attracted attention not only because of critical acclaim and market success, but also because of its use of Shanghainese. WhileMagnificent Flowersis the most notable recent book to make substantial use of Shanghainese, it is not alone, and the recent increase in the number of books that are written partially or even entirely in Shanghainese raises the question of whether written Shanghainese may develop a role in Chinese print culture, especially that of Shanghai and the surrounding region, similar to that attained by written Cantonese in and around Hong Kong.This study examines the history of written Shanghainese in print culture. Growing out of the older written Suzhounese tradition, during the early decades of the twentieth century a distinctly Shanghainese form of written Wu emerged in the print culture of Shanghai, and Shanghainese continued to play a role in Shanghai’s print culture through the twentieth century, albeit quite a modest one. In the first decade of the twenty-first century Shanghainese began to receive increased public attention and to play a greater role in Shanghai media, and since 2009 there has been an increase in the number of books and other kinds of texts that use Shanghainese and also the degree to which they use it.This study argues that in important ways this phenomenon does parallel the growing role played by written Cantonese in Hong Kong, but that it also differs in several critical regards. The most important difference is that, to date, written Shanghainese appears almost exclusively in texts that look back to “old Shanghai” and/or to traditional alley life in Shanghai, and that a role of the type written Cantonese has in Hong Kong is not likely to be attained unless or until Shanghainese texts that are associated with modern urban Shanghai life, especially youth culture, begin to appear.
Hydrodynamics Modeling of an LSCFB Reactor Using Multigene Genetic Programming Approach: Effect of Particles Size and Shape
Authors: Razzak Shaikh A. 
Published: September 2018

AbstractThe multigene genetic programming (MGGP) technique based hydrodynamics models were developed to predict the solids holdups of a liquid-solid circulating fluidized bed (LSCFB) riser. Four different particles were considered to investigate the effects of particle size, shape and density on hydrodynamics behavior of the LSCFB riser. In this regard, two spherical shape glass bead particles (500 and 1200 μm), two irregular shape lava rock particles (500 and 920 μm) were employed as solid phase and water as liquid phase. The MGGP models were developed, relating the solids holdup (${\varepsilon _s}$, output parameter) with eight input parameters. The developed models were first validated by comparing the model predicted and experimental data of solids holdups. The average solids holdups decreased with the increase of net superficial liquid velocity (${U_l} - {U_t}$) and normalized superficial liquid velocity$\left( {\frac{{{U_l}}}{{{U_t}}}} \right)$. Uniform axial solids holdups observed in axial locations (H) except close to the liquid-solid distributor of the riser. The radial non-uniformity of solids holdup observed all radial positions (r/R). In the central region almost flat but increased toward the wall region. The radial profiles of the solid holdup are approximately identical at a fixed average cross-sectional solid holdup for all of the three LSCFB systems of this study. The statistical performance indicators such as the mean absolute percentage error and correlation coefficient are also found to be within acceptable range. All these findings of suggest that the MGGP modeling approach is suitable for predicting effect of particle size and shape on hydrodynamics behavior of the LSCFB system
A Symmetric Van ’t Hoff Equation and Equilibrium Temperature Gradients
Authors: Sheehan D. P. 
Published: September 2018

Abstract
Thermodynamically isolated systems normally relax to equilibria characterized by single temperatures; however, in recent years several systems have been identified that challenge this presumption, demonstrating stationary temperature gradients at equilibrium. These temperature gradients, most pronounced in systems involving epicatalysis, can be explained via an underappreciated symmetry in the Van ’t Hoff equation.
Threshold models with time-varying threshold values and their application in estimating regime-sensitive Taylor rules
Authors: Zhu Yanli , Chen Haiqiang , Lin Ming 
Published: September 2018

Abstract
The literature of time series models with threshold effects makes the assumption of a constant threshold value over different periods. However, this time-homogeneity assumption tends to be too restrictive owing to the fact that the threshold value that triggers regime switching could possibly be time-varying. This study herein proposes a threshold model in which the threshold value is assumed to be a latent variable following an autoregressive (AR) process. The newly proposed model was estimated using a Markov Chain Monte Carlo (MCMC) algorithm under a Bayesian framework. The Monte Carlo simulations are presented to assess the effectiveness of the Bayesian approaches. An illustration of the model was made through an application to a regime-sensitive Taylor rule employing U.S. data.
A new aspect of the “pseudo water” concept of bis(trimethylsilyl)carbodiimide – “pseudohydrates” of aluminum
Authors: Krupinski Katrin , Brendler Erica , Gericke Robert , Wagler Jörg , Kroke Edwin 
Published: September 2018

Abstract
Bis(trimethylsilyl)carbodiimide (BTSC), so-called “pseudo water” because of some analogies such as similar (group)electronegativities of Me3Si– vs. H– and –N=C=N– vs. –O–, may form two different kinds of “pseudo hydrates” of metals (M), i.e. M–N(SiMe3)=C=N(SiMe3) and M–N≡C–N(SiMe3)2, derived from its carbodiimide and cyanamide isomeric forms, respectively. With anhydrous AlCl3 in Me3SiCl solution BTSC was shown to be capable of forming both kinds of solvates, i.e. Cl3Al–N(SiMe3)–C≡N(SiMe3) (1) and ((Cl3Al)(Me3Si)NCN)3–Al–(N≡C–N(SiMe3)2)3 (2). Both compounds were isolated as crystalline solids, which undergo condensation reactions upon storage. By single-crystal X-ray diffraction analysis the constitution of 1 was confirmed unambiguously, and quantum chemical calculations (B3LYP/6-311++g(d,p)) confirmed that compound 1 is 6 kcal mol−1 more stable than its hypothetical N,N-bis(trimethylsilyl)cyanamide isomer Cl3Al–N≡C–N(SiMe3)2. Compound 1 represents the first crystallographically confirmed disilylcarbodiimide complex of a metal salt. The molecules of compound 2 are heavily disordered in the solid state (positional disorder of N≡C–N(SiMe3)2 vs. N≡C–N(SiMe3)(AlCl3) and positional disorder of SiMe3 vs. AlCl3 groups in the latter). Therefore, the identity of 2 was additionally confirmed by 13C, 15N, 27Al and 29Si CP/MAS NMR spectroscopy.
Relationship Between Maximal Dynamic Force in the Deep Back Squat and Sprinting Performance in Consecutive Segments Up to 30 m
Authors: Möck Sebastian , Hartmann René , Wirth Klaus , Rosenkranz Gregor , Mickel Christoph 
Published: September 2018

Abstract
Möck, S, Hartmann, R, Wirth, K, Rosenkranz, G, and Mickel, C. Relationship between maximal dynamic force in the deep back squat and sprinting performance in consecutive segments up to 30 m. J Strength Cond Res 35(4): 1039–1043, 2021—The sprint (in track and field athletics) is characterized by a fluent transition from predominantly knee extending musculature during the initial acceleration phase toward dominance of the hamstring muscle group thereafter. Because of this change in technique, it can be assumed that there is a decrease of correlation of the maximal dynamic force of the deep back squat and sprinting performance with increasing distance. Therefore, sprinting performance for consecutive intervals (0–5, 5–10, 10–15, 15–20, 20–25, and 25–30 m) as well as the 1 repetition maximum (1RM) were determined. Our results show statistically significant (p < 0.01) correlations for both the relationships with the absolute 1RM (r = −0.614 to −0.808) and the relative 1RM (r = −0.646 to −0.749). However, the expected decrease in correlation over distance was not found. The results show that the maximal dynamic force of hip and knee extensors are a basic performance requirement in short-distance sprinting and should be considered in training recommendations.
Injury Prevention Programs Based on Flywheel vs. Body Weight Resistance in Recreational Athletes
Authors: Monajati Alireza , Larumbe-Zabala Eneko , Goss-Sampson Mark , Naclerio Fernando 
Published: September 2018

Abstract
Monajati, A, Larumbe-Zabala, E, Sampson, MG, and Naclerio, F. Injury prevention programs based on flywheel vs. body weight resistance in recreational athletes. J Strength Cond Res 35(2S): S188–S196, 2021—This study compares the effect of an isoinertial flywheel technology vs. a traditional gravity-dependent exercise protocol on modifiable factors associated with the incidence of hamstring strain (HAM) and anterior cruciate ligament (ACL) injuries. Furthermore, the effect on repeated sprint ability was also considered. Eighteen recreationally trained volleyball players completed one of the following 6-week protocols: (a) flywheel (FY) included 3 exercises using a YoYo isoinertial-squat machine and 3 exercises with a Versa-Pulley isoinertial device, and (b) gravity-dependent (GT) involved 6 similar exercises with no external resistance (participants' body weight). Both programs consisted in 2 sessions·wk−1 performing 2 sets of 8 repetitions with 2 minutes of rest. Outcomes included a 10-second tuck jump assessment (TJA), landing knee valgus score, hamstring and quadriceps concentric and eccentric isokinetic 60°·s−1 peak torque, optimal peak torque localization, conventional and functional hamstring-to-quadriceps ratio, and 30-m repeated shuttle sprint ability (RSSA) test. FY improved TJA (−2, interquartile range [IQR] = −3 to −1) and valgus (−1, IQR = −1 to 0) scores, hamstring eccentric (20.37, 95% confidence interval [CI] = 9.27–31.47 N·m) and concentric (17.87, 95% CI = 0.40–35.34 N·m) peak torque, as well as the RSSA (−0.28, 95% CI = −0.45 to −0.10 seconds), whereas GT only improved hamstring eccentric peak torque (21.41, 95% CI = 9.00–33.82 N·m). A 6-week protocol using flywheel technology seems to elicit better positive adaptations to protect athletes from HAM and ACL injuries and to enhance RSSA performance compared to exercising with no external resistance other than athletes' body weight.
Resistance to thyroid hormone accompanied by atrial fibrillation
Authors: Sato Haruhiro , Tomita Yuichiro 
Published: October 2018

Summary
Resistance to thyroid hormone (RTH), which is primarily caused by mutations in the thyroid hormone (TH) receptor beta (THRB) gene, is dominantly inherited syndrome of variable tissue hyposensitivity to TH. We herein describe a case involving a 22-year-old Japanese man with RTH and atrial fibrillation (AF) complaining of palpitation and general fatigue. Electrocardiography results revealed AF. He exhibited elevated TH levels and an inappropriately normal level of thyroid-stimulating hormone (TSH). Despite being negative for anti-TSH receptor antibody, thyroid-stimulating antibody and anti-thyroperoxidase antibody, the patient was positive for anti-thyroglobulin (Tg) antibody. Genetic analysis of the THRB gene identified a missense mutation, F269L, leading to the diagnosis of RTH. Normal sinus rhythm was achieved after 1 week of oral bisoprolol fumarate (5 mg/day) administration. After 3 years on bisoprolol fumarate, the patient had been doing well with normal sinus rhythm, syndrome of inappropriate secretion of TSH (SITSH) and positive titer of anti-Tg antibody.

Learning points:

Atrial fibrillation can occur in patients with RTH.

Only a few cases have been reported on the coexistence of RTH and atrial fibrillation.

No consensus exists regarding the management of atrial fibrillation in patients with RTH.

Administration of bisoprolol fumarate, a beta-blocker, can ameliorate atrial fibrillation in RTH.
A novel CASR mutation (p.Glu757Lys) causing autosomal dominant hypocalcaemia type 1
Authors: Kwan Benjamin , Champion Bernard , Boyages Steven , Munns Craig F , Clifton-Bligh Roderick , Luxford Catherine , Crawford Bronwyn 
Published: October 2018

Summary
Autosomal dominant hypocalcaemia type 1 (ADH1) is a rare familial disorder characterised by low serum calcium and low or inappropriately normal serum PTH. It is caused by activating CASR mutations, which produces a left-shift in the set point for extracellular calcium. We describe an Australian family with a novel heterozygous missense mutation in CASR causing ADH1. Mild neuromuscular symptoms (paraesthesia, carpopedal spasm) were present in most affected individuals and required treatment with calcium and calcitriol. Basal ganglia calcification was present in three out of four affected family members. This case highlights the importance of correctly identifying genetic causes of hypocalcaemia to allow for proper management and screening of family members.

Learning points:

ADH1 is a rare cause of hypoparathyroidism due to activating CASR mutations and is the mirror image of familial hypocalciuric hypercalcaemia.

In patients with ADH1, symptoms of hypocalcaemia may be mild or absent. Basal ganglia calcification may be present in over a third of patients.

CASR mutation analysis is required for diagnostic confirmation and to facilitate proper management, screening and genetic counselling of affected family members.

Treatment with calcium and activated vitamin D analogues should be reserved for symptomatic individuals due to the risk of exacerbating hypercalciuria and its associated complications.
BMP Signaling Determines Body Size via Transcriptional Regulation of Collagen Genes in Caenorhabditis elegans
Authors: Madaan Uday , Yzeiraj Edlira , Meade Michael , Clark James F , Rushlow Christine A , Savage-Dunn Cathy 
Published: October 2018

Abstract
Body size is a tightly regulated phenotype in metazoans that depends on both intrinsic and extrinsic factors. While signaling pathways are known to control organ and body size, the downstream effectors that mediate their effects remain poorly understood. In the nematode Caenorhabditis elegans, a Bone Morphogenetic Protein (BMP)-related signaling pathway is the major regulator of growth and body size. We investigated the transcriptional network through which the BMP pathway regulates body size and identified cuticle collagen genes as major effectors of growth control. We demonstrate that cuticle collagens can act as positive regulators (col-41), negative regulators (col-141), or dose-sensitive regulators (rol-6) of body size. Moreover, we find a requirement of BMP signaling for stage-specific expression of cuticle collagen genes. We show that the Smad signal transducers directly bind conserved Smad-binding elements in regulatory regions of col-141 and col-142, but not of col-41. Hence, cuticle collagen genes may be directly and indirectly regulated via the BMP pathway. Our work thus connects a conserved signaling pathway with its critical downstream effectors, advancing insight into how body size is specified. Since collagen mutations and misregulation are implicated in numerous human genetic disorders and injury sequelae, understanding how collagen gene expression is regulated has broad implications.
Care Standardization Reduces Blood Donor Exposures and Transfusion in Complex Cranial Vault Reconstruction
Authors: Muhly Wallis T. , Tan Jonathan M. , Hsu Grace , Sesok-Pizzini Deborah A. , Fiadjoe John E. , Taylor Jesse A. , Bartlett Scott P. , Stricker Paul A. 
Published: October 2018

BACKGROUND:
Complex cranial vault reconstruction (CCVR) often requires a large-volume transfusion of blood products. We implemented a series of improvement interventions to reduce blood donor exposures (BDE) and transfusion requirements in CCVR.

METHODS:
We implemented interventions over 4 epochs: (E1) reconstituted blood (1:1 ratio of donor-matched red blood cells and fresh-frozen plasma) for intraoperative transfusions, (E2) reconstituted blood plus postoperative transfusion guidelines, (E3) reconstituted blood plus intraoperative antifibrinolytics and postoperative guidelines, and (E4) fresh whole blood for intraoperative transfusion, antifibrinolytics, and postoperative guidelines. Primary outcomes, BDE, and total volume of blood products transfused are presented by using statistical process control charts, with statistical comparisons between each epoch and baseline data.

RESULTS:
We included 347 patients &lt;72 months old who underwent CCVR between 2008 and 2016 (E1: n = 50; E2: n = 41; E3: n = 87; and E4: n = 169). They were compared with a baseline sample group of 138 patients who were managed between 2001 and 2006. Compared with our baseline group, patients in each epoch had a significant reduction in BDE (P = .02–&lt;.0001). Conversely, compared with the baseline group, we observed an increase the volume of blood products transfused in E1 (P = .004), no difference in E2 (P = .6) or E3 (P = .46), and a reduction in the volume of blood products transfused in E4 (P &lt; .0001).

CONCLUSIONS:
The implementation of sequential clinical improvement strategies resulted in a sustained reduction in BDE whereas only the use of whole blood resulted in a significant reduction in the total volume of blood products transfused in children undergoing CCVR.
Inducción de tolerancia inmunológica: alotrasplantes compuestos vascularizados y trasplantes de órgano sólido
Authors: Espinel-Pinzón Daniel Alejandro , Figueroa-Bohorquez David , Lozano-Márquez Eyner 
Published: October 2018

Introducción. La inducción de tolerancia inmunológica solucionaría los problemas asociados con la inmunosupresión de por vida, necesaria para evitar el rechazo de aloinjertos.Objetivos. Revisar aspectos inmunológicos, modelos clínicos utilizados y resultados obtenidos en la tolerancia y comparar los resultados obtenidos con trasplante de órgano sólido y alotrasplante compuesto vascularizado.Materiales y métodos. Se realizó una búsqueda en la base de datos PubMed que arrojó 299 resultados; se revisaron las bibliografías de los artículos y se consultaron las referencias pertinentes. Al final se seleccionaron 83 artículos.Resultados. Existen mecanismos centrales y periféricos para mantener la tolerancia a antígenos propios; en la práctica clínica, la tolerancia central ha sido más utilizada, esto se ha hecho mediante estrategias que utilizan trasplante conjunto de medula ósea. Varios ensayos clínicos, la mayoría en pacientes con trasplante renal, han mostrado resultados prometedores pero inconsistentes.Conclusiones. En trasplantes renales fue posible suspender de forma exitosa la inmunosupresión, mientras que en trasplantes de mano se logró disminuirla considerablemente. El quimerismo inmunológico parece ser indispensable para el desarrollo de tolerancia a aloinjertos, por lo que es necesario desarrollar protocolos para inducir quimerismo mixto persistente.
Prevalencia de infección del tracto urinario, uropatógenos y perfil de susceptibilidad en un hospital de Cartagena, Colombia. 2016
Authors: Alviz-Amador Antistio , Gamero-Tafur Kevin , Caraballo-Marimon Roger , Gamero-Tafur José 
Published: October 2018

Introducción. Dada la alta prevalencia de la infección del tracto urinario (ITU) y la significativa resistencia de los patógenos implicados, el mundo se enfrenta a un problema creciente de salud pública.Objetivos. Describir la prevalencia de ITU y uropatógenos y analizar los perfiles de susceptibilidad en los reportes de urocultivos del laboratorio de microbiología de un hospital de referencia.Materiales y métodos. Se llevó a cabo un estudio transversal con una muestra de 396 urocultivos positivos en el que se calculó la prevalencia de ITU, uropatógenos y perfil de resistencia microbiana. Se realizaron pruebas de hipótesis y regresión logística no condicional para conocer si existía diferencia estadística entre el género.Resultados. La prevalencia de ITU fue del 28%, los tres patógenos aislados más frecuentes fueron Escherichia coli, Escherichia. coli con ß-lactamasas de espectro extendido y Pseudomonas. aeruginosa. La mayor frecuencia de resistencia a antibióticos para estos patógenos fue ampicilina (66.6%), ceftriaxona (100%) y gentamicina (39.5%), respectivamente.Conclusiones. Por la alta prevalencia, el amplio espectro de uropatógenos aislados y la diversidad de perfiles de resistencia antibiótica, se evidencia la necesidad de desarrollar investigaciones locales que permitan orientar las acciones en salud y vigilancia epidemiológica.
Prácticas, actitudes y conocimientos en relación a la terapia electroconvulsiva
Authors: Guzmán-Sabogal Yahira Rossini , Tejada-Morales Paola Andrea , Acero-González Ángela Rocío , Ruiz-Moreno Lina María , Romero-Tapia Alvaro Enrique 
Published: October 2018

Introducción. A pesar de la utilidad de la terapia electroconvulsiva (TEC), existe prevención hacia su uso en varios grupos poblacionales.Objetivos. Explorar y describir, desde el punto de vista de psiquiatras, médicos no psiquiatras y comunidad en general, los conocimientos, prácticas y actitudes respecto a la TEC.Materiales y métodos. Este fue un estudio de grupos focales en el que se hizo un análisis temático de las entrevistas.Resultados. Se evidenció que en la población general hay opiniones diversas, la mayoría negativas, y poco conocimiento, el cual proviene de la industria cinematográfica. Aceptar un tratamiento de TEC es siempre la última opción, pero con mayor información al respecto podría ser más considerado. Aunque los médicos muestran interés por conocer estudios sobre TEC, refieren que no han recibido formación y entrenamiento al respecto, además desconocen los avances en el tema. En el grupo de psiquiatras, los conocimientos, prácticas y actitudes dependieron de la experiencia y contacto con la TEC, pues aunque conocen su existencia, la mayoría no la usa ni la recomienda.Conclusión. Las prácticas y actitudes respecto a TEC en las poblaciones estudiadas varían según las experiencias y conocimientos que se tengan de este procedimiento.