bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Altitude Acclimatization Improves Recovery from Muscle Fatigue
Authors: RUGGIERO LUCA , HOILAND RYAN L. , HANSEN ALEXANDER B. , AINSLIE PHILIP N. , MCNEIL CHRIS J. 
Published: July 2019

ABSTRACT

Purpose
We investigated the effect of high-altitude acclimatization on peripheral fatigue compared with sea level and acute hypoxia.

Methods
At sea level (350 m), acute hypoxia (environmental chamber), and chronic hypoxia (5050 m, 5–9 d) (partial pressure of inspired oxygen = 140, 74 and 76 mm Hg, respectively), 12 participants (11 in chronic hypoxia) had the quadriceps of their dominant leg fatigued by three bouts of 75 intermittent electrically evoked contractions (12 pulses at 15 Hz, 1.6 s between train onsets, and 15 s between bouts). The initial peak force was ~30% of maximal voluntary force. Recovery was assessed by single trains at 1, 2, and 3 min postprotocol. Tissue oxygenation of rectus femoris was recorded by near-infrared spectroscopy.

Results
At the end of the fatigue protocol, the impairments of peak force and peak rates of force development and relaxation were greater (all P < 0.05) in acute hypoxia (~51%, 53%, and 64%, respectively) than sea level (~43%, 43%, and 52%) and chronic hypoxia (~38%, 35%, and 48%). Peak force and rate of force development recovered faster (P < 0.05) in chronic hypoxia (pooled data for 1–3 min: ~84% and 74% baseline, respectively) compared with sea level (~73% and 63% baseline) and acute hypoxia (~70% and 55% baseline). Tissue oxygenation did not differ among conditions for fatigue or recovery (P > 0.05).

Conclusions
Muscle adaptations occurring with chronic hypoxia, independent of other adaptations, positively influence muscle contractility during and after repeated contractions at high altitude.
Athlete–Opponent Interdependency Alters Pacing and Information-Seeking Behavior
Authors: KONINGS MARCO J. , FOULSHAM TOM , MICKLEWRIGHT DOMINIC , HETTINGA FLORENTINA J. 
Published: July 2019

ABSTRACT

Purpose
The influence of interdependency between competitors on pacing decision-making and information-seeking behavior has been explored. This has been done by only altering instructions, and thereby action possibilities, while controlling environment (i.e., competitor behavior) and exercise task.

Methods
Twelve participants performed a 4-km time trial on a Velotron cycle ergometer in a randomized, counterbalanced order alone with no virtual opponent (NO), against a virtual opponent with no restrictions (low athlete–opponent interdependency [OP-IND]), or against a virtual opponent who the participant was permitted to overtake only once during the trial (high athlete–opponent interdependency [OP-DEP]). Information-seeking behavior was evaluated using an SMI eye tracker. Differences in pacing, performance, and information-seeking behavior were examined using repeated-measures ANOVA (P < 0.05).

Results
Neither mean power output (NO, 298 ± 35 W; OP-IND, 297 ± 38 W; OP-DEP, 296 ± 37 W) nor finishing time (NO, 377.7 ± 17.4 s; OP-IND, 379.3 ± 19.5 s; OP-DEP, 378.5 ± 17.7 s) differed between experimental conditions. However, power output was lower in the first kilometer of OP-DEP compared with the other experimental conditions (NO, 332 ± 59 W; OP-IND, 325 ± 62 W; OP-DEP, 316 ± 58 W; both P < 0.05), and participants decided to wait longer before they overtook their opponent (OP-IND, 137 ± 130 s; OP-DEP, 255 ± 107 s; P = 0.040). Moreover, total fixation time spent on the avatar of the virtual opponent increased when participants were only allowed to overtake once (OP-IND, 23.3 ± 16.6 s; OP-DEP, 55.8 ± 32.7 s; P = 0.002).

Conclusion
A higher interdependency between athlete and opponent altered pacing behavior in terms of in-race adaptations based on opponent’s behavior, and it induced an increased attentional focus on the virtual opponent. Thus, in the context of exercise regulation, attentional cues are likely to be used in an adaptive way according to their availability and situational relevance, consistent with a decision-making framework based on the interdependence of perception and action.
Changes in Fatigue Are the Same for Trained Men and Women after Resistance Exercise
Authors: MARSHALL PAUL W. , METCALF EMILY , HAGSTROM AMANDA D. , CROSS REBECCA , SIEGLER JASON C. , ENOKA ROGER M. 
Published: July 2019

ABSTRACT

Purpose
To measure changes in fatigue and knee-extensor torque in the 48 h after trained men and women completed a full-body resistance exercise session.

Methods
Eight trained women (mean ± SD: age, 25.6 ± 5.9 yr; height, 1.68 ± 0.06 m; mass, 71.0 ± 8.6 kg) and eight trained men (age, 25.5 ± 6.2 yr; height, 1.79 ± 0.05 m; mass, 86.4 ± 9.8 kg) performed a full-body resistance exercise session based on real-world athletic practice. Measurements were performed before and after the exercise session, as well as 1, 24, and 48 h after the session. Fatigue and pain were measured with standardized self-report measures. Maximal isometric contractions with the knee extensors and superimposed femoral nerve stimulation were performed to examine maximal torque, rate of torque development, voluntary activation, and muscle contractility. Two sets of 10 isokinetic contractions (60°·s−1) with the knee extensors were performed during the protocol with use of near-infrared spectroscopy to assess muscle oxygenation. EMG were recorded from two quadriceps muscles during all isometric and isokinetic contractions.

Results
Fatigue was increased from baseline for both sexes until 48 h after training (P < 0.001). Maximal torque and evoked twitch amplitudes were similarly reduced after exercise for men and women (P < 0.001). Voluntary activation and EMG amplitudes were unchanged after the training session. Muscle oxygenation was 13.3% ± 17.4% (P = 0.005) greater for women during the isokinetic repetitions, and the values were unchanged after the training session.

Conclusions
This is the first study to show similar changes in the fatigue reported by trained men and women in the 48 h after a training session involving full-body resistance exercises. Sex differences in muscle oxygenation during exercise do not influence the reductions in muscle force, activation, or contractility after the training session.
Post-mortem computed tomography in adult non-suspicious death investigation—evaluation of an NHS based service
Authors: Robinson Claire , Deshpande Aparna , Richards Cathy , Rutty Guy , Mason Catherine , Morgan Bruno 
Published: July 2019

Objective: Post-mortem CT (PMCT) can replace autopsy in many cases of non-suspicious death. A purely NHS-based service to replace autopsy with PMCT was launched, with the cost met by the family from 2015 to 2017, and subsequently “free at the point of delivery” after local authority funding was secured. The aim of the service was to improve the experience for the families. This report describes and evaluates the service against local standards of (1) less than four day turn around, (2) cause of death given in >90% and (3) less than 10% require autopsy. Methods: A retrospective review of reports, records and emails was undertaken to collate demographics, times of different stages of the process, the outcome and comments from service users. Results: Between July 2015 and July 2018, 279 patients had PMCT scans, 67 (24.0%) in the family-funded service and 212 (76%) in the current service. 97.1% (n = 271/279) of cases had the radiology report issued by day 3 (96.8% vs 98.6% for the family funded and local authority-funded services respectively). A cause of death was given in 97.2% of scans. 2.8% of patients required autopsy. Feedback from families, coroner’s officers and undertakers has been overwhelmingly positive. Conclusion: The services exceeded local standards and met the needs of the Coroner and the families based on the feedback received. This model could be employed for similar services, but the change to the logistics and financial structures required to initiate such services remains a significant hurdle. Advances in knowledge: This is the first report of a fully NHS-based PMCT service.
Sleep assessment and interventions for patients living with cancer from the patients' and nurses' perspective
Authors: Khater Wejdan , Masha'al Dina , al-Sayaheen Aseel 
Published: July 2019

Background: Difficulty sleeping is a common symptom for patients living with cancer that significantly affects their lives. However, although sleep disorders are common, it is an overlooked problem in cancer care. Purpose: This study assessed the prevalence of sleep disturbances among patients living with cancer, and assessed the adequacy of sleep assessment and intervention for patients from both nurses' and patients' perspectives. Method: Descriptive, cross-sectional and correlational design was used in this study. A convenience sample of 129 patients with cancer and 113 registered nurses working with cancer patients was recruited. A structured face-to-face interview was used to complete the patients' questionnaires and a self-administered questionnaire was given to nurses. Findings: The majority of patients with cancer reported having poor sleep quality (69.8%). About 86.7% (n=98) of nurses reported that they have never screened patients with cancer for any sleep problems, and 76.7% (n=99) of the patients reported that they have never been assessed for sleep problems by the nursing staff during hospitalisation. Only 8% of patients with cancer who reported having problems sleeping to a nurse received interventions to promote better sleep. Conclusion: Assessment of sleep disturbances in patients with cancer should be unified using a comprehensive reliable valid instrument, as well as providing evidence-based interventions according to patient's need. A written policy should be introduced to encourage sleep documentation and to make sleep care for patients part of routine nursing care.
The Gut Microbiota in Collagenous Colitis Shares Characteristics With Inflammatory Bowel Disease-Associated Dysbiosis
Authors: Carstens Adam , Dicksved Johan , Nelson Ronald , Lindqvist Mårten , Andreasson Anna , Bohr Johan , Tysk Curt , Talley Nicholas J. , Agréus Lars , Engstrand Lars , Halfvarson Jonas 
Published: July 2019

INTRODUCTION:
In inflammatory bowel disease (IBD), an aberrant immune response to gut microbiota is important, but the role of the microbiota in collagenous colitis (CC) is largely unknown. We aimed to characterize the microbiota of patients with CC compared with that of healthy control and patients with IBD.

METHODS:
Fecal samples were collected from patients with CC (n = 29), age- and sex-matched healthy controls (n = 29), patients with Crohn's disease (n = 32), and patients with ulcerative colitis (n = 32). Sequence data were obtained by 454 sequencing of 16S rRNA gene amplicons, and the obtained sequences were subsequently taxonomically classified.

RESULTS:
Analysis of similarity statistics showed a segregation between patients with CC and healthy controls with increasing taxonomic resolution, becoming significant comparing operational taxonomic unit data (P = 0.006). CC had a lower abundance of 10 different taxa. Taxa-specific analyses revealed a consistent lower abundance of several operational taxonomic units belonging to the Ruminococcaceae family in patients with CC, q < 0.05 after false discovery rate correction. Loss of these taxa was seen in patients with CC with active disease and/or corticosteroid treatment only and resembled the findings in patients with IBD.

DISCUSSION:
CC is associated with a specific fecal microbiome seen primarily in patients with active disease or ongoing corticosteroid treatment, whereas the microbiome of CC patients in remission resembled that of healthy controls. Notably, the shift in key taxa, including the Ruminococcaceae family, was also observed in IBD. There may be common mechanisms in the pathogenesis of CC and IBD.
Ideal Dasar Prima Dalam Aljabar Atas Suatu Ring Komutatif
Authors: Wardati Khurul 
Published: July 2019

Definisi ideal dasar dan ideal bebas dalam aljabar bebas atas ring komutatif dengan elemen satuan adalah ekuivalen. Namun, ideal dasar dalam suatu aljabar tak bebas belum tentu merupakan ideal bebas, sementara ideal bebas pasti ideal dasar. Artikel ini membahas beberapa sifat ideal dasar prima dalam aljabar tak bebas atas ring komutatif dengan elemen satuan.
[The definitions of basic ideal and free ideal in free algebras over a unital commutative ring are equivalen. However, a basic ideal in the non-free algebra is not neceearily a free ideal, while any free ideal is definitely a basic ideal. This paper will discuss some properties of prime basic ideal in non-free algebras over a unital commutative ring.]
Penerapan Persamaan Diferensial Verhulst dalam Menentukan Proyeksi Penduduk di Kabupaten Tulungagung
Authors: Anggreini Dewi 
Published: July 2019

Penelitian ini bertujuan menentukan proyeksi pertumbuhan penduduk di Kabupaten Tulungagung provinsi Jawa Timur dengan model persamaan diferensial Verhulst berdasarkan laju pertumbuhan dan daya tampung (carrying capacity). Target khusus dari hasil penelitian ini adalah model pertumbuhan logistik bisa digunakan sebagai alat untuk mengetahui proyeksi pertumbuhan penduduk berdasarkan laju pertumbuhan dan daya tampung dibeberapa daerah di Indonesia. Metode riset yang digunakan pada tahap pertama adalah menentukan subjek penelitian dan tahap Kedua adalah (1) mengumpulkan data penelitian (2) analisis data dan terakhir menarik kesimpulan. Data penelitian ini diperoleh dari BPS Kabupaten Tulungagung yaitu jumlah penduduk dari tahun 2010-2016. Hasil Penelitian menunjukkan bahwa: 1) Besarnya nilai carrying capacity yang membatasi penduduk di Kabupaten Tulungagung adalah sebesar 1.089.103,3. 2) Laju pertumbuhan intrinsik penduduk di kabupaten Tulungagung dengan menggunakan Model pertumbuhan logistik adalah sebesar r = 0,07480. 3) Jumlah penduduk di Kabupaten Tulungagung pada tahun 2025 dari hasil estimasi menggunakan model pertumbuhan logistik adalah sebesar 1.055.578 jiwa. 4) Proyeksi jumlah penduduk di Kabupaten Tulungagung lebih tepat menggunakan model logistik I dengan persamaannya . Penelitian ini diharapkan dapat bermanfaat bagi semua pihak khususnya pada bidang matematika terapan serta metode dalam menghitung pertumbuhan populasi di suatu daerah pada periode yang akan datang.
[This study aims to determine the projected population growth in Tulungagung Regency of East Java province with a model of Verhulst differential equations based on growth rate and carrying capacity. The specific target of this research is logistic growth model can be used as a tool to know the projection of population growth based on growth rate and capacity in some regions in Indonesia. Research methods used in the first stage is to determine the subject of research and the second stage is (1) collect research data (2) data analysis and last draw conclusions. The data of this research is obtained from BPS of Tulungagung Regency that is population from 2010-2016. The results showed that: 1) The amount of carrying capacity that limits the population in Tulungagung Regency is equal 1.089.103,3. 2) The intrinsic growth rate of the population in Tulungagung district using the logistic growth model is r = 0,07480 3) The population in Tulungagung District in 2025 from the estimation using the logistic growth model is 1.055.578 soul, 4) The projection of population in Tulungagung is more appropriate using the logistic model I with the equation . This study is expected to be useful for all parties, especially in the field of applied mathematics and methods in calculating population growth in an area in the period to come.]
Effects of self-regulated learning strategy use on motivation in EFL writing: A comparison between high and low achievers in Hong Kong primary schools
Authors: Guo Wenjuan , Bai Barry 
Published: July 2019

Abstract
This study aimed to explore the effects of SRL strategy use on primary school students’ motivation (i.e. self-efficacy and interest) in EFL writing and to compare the differences in such effects between high and low achievers. Participants were 374 4th graders in Hong Kong. Results of t-tests indicated that the high achievers reported significantly a higher level of SRL strategy use (i.e. planning, self-monitoring, and revising) and motivation (i.e. self-efficacy and interest) in EFL writing than their low-achieving peers. Results of two-group structural equation modeling (SEM) indicated that the high achievers’ motivation increased through the use of planning and self-monitoring strategies in writing, while the low achievers’ motivation increased through the use of self-monitoring and revising strategies. The high achievers showed a high level of self-efficacy and the low achievers a low level. However, both groups of students did not show a high level of interest in EFL writing. Implications for future research and English teachers to improve students’ motivation in writing through use of SRL strategies are discussed.
Determining Potential Feed Value and Silage Quality of Guar Bean (Cyamopsis tetragonoloba) Silages
Authors: Olfaz Mustafa , Kilic Unal , Yavrucu Oguzhan 
Published: July 2019

AbstractThis study was carried out to determine the effects of some additives on the potential nutritional value and silage quality of guar bean (Cluster bean = Cyamopsis tetragonoloba) silages. It was hypothesized that the use of cereal grains, molasses and ecomass will reduce silage fermentation pH by increasing lactic acid production and positively improve CP content and silage quality. Four different silage groups were established; (control, grain (5%), molasses (10%) and ecomass+molasses (10%+5%)). Fresh guar beans were thoroughly mixed with the additives to homogenize, then ensiled and opened after 60 days. The results of this study revealed that guar bean silages could be used as an alternative forage in ruminant feeding because of its higher protein content (13.88%), forage feed value and silage quality. The use of molasses (GSM) and molasses + ecomass (GSEM) as additives has significantly (P ≤0.01) increased the silage quality and feed value compared to the control group. It was observed that GSM and GSEM silage groups had the highest values in terms of lactic acid content. In conclusion, guar silage can be used as an alternative feed for ruminants, but the doses of barley and molasses should be correct and tested in in vivo studies.
Study of the analytical performance at different concentrations of hematological parameters using Spanish EQAS data
Authors: Molina Angel , Alcaraz José , Guiñón Leonor , Pérez Aránzazu , Segurana Anna , Reverter Joan Carles , Bedini Josep Lluís , Merino Anna 
Published: July 2019

Abstract

Background
External quality assessment programs are one of the currently available tools to evaluate the analytical performance of clinical laboratories, where the measurement error (ME) obtained can be compared with quality specifications to evaluate possible deviations. The objective of this work was to analyze the ME behavior over the analytical range to assess the need to establish concentration-dependent specifications.

Methods
A total of 389,000 results from 585 laboratories and 2628 analyzers were collected from the Spanish external quality assessment schemes (EQAS) in hematology during the years 2015–2016. The parameters evaluated included white blood cells, red blood cells, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelets, prothrombin time, activated partial thromboplastin time, neutrophils, lymphocytes, monocytes, eosinophils, basophils, reticulocytes, hemoglobin A2, antithrombin, factor VIII, protein C and von Willebrand factor. The 90th percentile of ME was calculated for every concentration evaluated of each parameter.

Results
We found a significant variation in the analytical performance of leukocytes, platelets, neutrophils, lymphocytes, monocytes, eosinophils, basophils, prothrombin time, reticulocytes, hemoglobin A2, antithrombin and protein C. Furthermore, this ME variation may not allow complying with the same biological variability requirements within the whole analytical range studied.

Conclusions
Our work shows the importance of implementing concentration-dependent specifications which can help laboratories to use proper criteria for quality specifications selection and for a better external quality control results evaluation.
Analytical and clinical validation of a novel amplicon-based NGS assay for the evaluation of circulating tumor DNA in metastatic colorectal cancer patients
Authors: Wang Beili , Wu Shengchao , Huang Fei , Shen Minna , Jiang Huiqin , Yu Yiyi , Yu Qian , Yang Yihui , Zhao Ying , Zhou Yiwen , Pan Baishen , Liu Tianshu , Guo Wei 
Published: July 2019

Abstract

Background
Evaluating the tumor RAS/BRAF status is important for treatment selection and prognosis assessment in metastatic colorectal cancer (mCRC) patients. Correction of artifacts from library preparation and sequencing is essential for accurately analyzing circulating tumor DNA (ctDNA) mutations. Here, we assessed the analytical and clinical performance of a novel amplicon-based next-generation sequencing (NGS) assay, Firefly™, which employs a concatemer-based error correction strategy.

Methods
Firefly assay targeting KRAS/NRAS/BRAF/PIK3CA was evaluated using cell-free DNA (cfDNA) reference standards and cfDNA samples from 184 mCRC patients. Plasma results were compared to the mutation status determined by ARMS-based PCR from matched tissue. Samples with a mutation abundance below the limit of detection (LOD) were retested again by droplet digital polymerase chain reaction (ddPCR) or NGS.

Results
The Firefly assay demonstrated superior sensitivity and specificity with a 98.89% detection rate at an allele frequency (AF) of 0.2% for 20 ng cfDNA. Generally, 40.76% and 48.37% of the patients were reported to be positive by NGS of plasma cfDNA and ARMS of FFPE tissue, respectively. The concordance rate between the two platforms was 80.11%. In the pre-treatment cohort, the concordance rate between plasma and tissue was 93.33%, based on the 17 common exons that Firefly™ and ARMS genotyped, and the positive percent agreement (PPA) and negative percent agreement (NPA) for KRAS/NRAS/BRAF/PIK3CA were 100% and 99.60%, respectively.

Conclusions
Total plasma cfDNA detected by Firefly offers a viable complement for mutation profiling in CRC patients, given the high agreement with matched tumor samples. Together, these data demonstrate that Firefly could be routinely applied for clinical applications in mCRC patients.
Pluralized non-count nouns across Englishes: A corpus-linguistic approach to variety types
Authors: Schneider Gerold , Hundt Marianne , Schreier Daniel 
Published: July 2019

AbstractThis corpus-based study of pluralized non-count nouns (informations,advices, etc.) uses collocation-derived measures (determiners vs. bare noun and mass quantifiers) to extract potential candidates of non-count nouns in a bottom-up approach from theBritish National Corpus (BNC),allowing the detection of grammatical categories from distributional features. We then use this token list to retrieve data on pluralization of non-counts from nine annotated components of theInternational Corpus of English (ICE). While the distinction between count and non-count nouns is gradient rather than categorical, it is still possible to distinguish between standard and non-standard pluralization of non-counts. Qualitative analyses of our data show that non-standard pluralization of non-count nouns is regularly attested in second-language varieties, including previously unrecorded types; however, it is also occasionally found in first-language varieties. We discuss implications of our corpus results for common explanations of pluralized non-count nouns, such as substrate influence, language learning effects and historical input. By combining a bottom-up corpus-based approach with fine-grained qualitative analyses we can provide a more nuanced view of pluralization of non-counts across ENL and ESL for the investigation of World Englishes.