bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coagulation Laboratory Testing Is Predictive of Wound Complications Following Microdiscectomy
Authors: Goz Vadim , Lakomkin Nikita , Jalali Ali , Brodke Darrel S. , Spiker William R. 
Published: August 2018

Study Design: Retrospective review. Objective: To determine whether abnormal preoperative testing is associated with postoperative complications in patients undergoing a microdiscectomy. Methods: Patients undergoing a microdiscectomy between 2006 and 2013 were identified in the National Surgical Quality Improvement Program database based on appropriate current procedural terminology coding. Thirty-day postoperative complications were analyzed in addition to patient demographics, comorbidities, and abnormal preoperative laboratory values. A series of over 650 univariate analyses to determine which independent variables to include for each complication were completed. Based on those analyses, 12 logistic regression models were built, one for each specific complication. Each model adjusted for age, gender, comorbidities, American Society of Anesthesiologists classification, as well as operative time. Results: A total of 5947 patients undergoing a microdiscectomy were included in the study. Abnormal preoperative international normalized ratio (odds ratio [OR] = 5.85, P < .05) was associated with any wound infection, superficial or deep, and abnormal partial thromboplastin time was significantly associated with wound dehiscence (OR = 6.80, P < .05). Postoperative urinary tract infections were associated with abnormal preoperative hematocrit (OR = 8.00, P < .05). None of the identified preoperative labs were independently associated with pulmonary embolism, organ space surgical site infections, or intubation. Conclusions: Abnormal preoperative coagulation labs were significantly associated with postoperative wound complications. However, the majority of tests were not associated with adverse events following microdiscectomy. Further study is necessary to conclude whether these tests provide information that can modify perioperative management and whether widespread testing is cost-effective.
A Controlled Comparison of Microfracture, Debridement, and No Treatment of Concomitant Full-Thickness Cartilage Lesions in Anterior Cruciate Ligament–Reconstructed Knees: A Nationwide Prospective Cohort Study From Norway and Sweden of 368 Patients With 5-Year Follow-up
Authors: Ulstein Svend , Årøen Asbjørn , Engebretsen Lars , Forssblad Magnus , Lygre Stein Håkon Låstad , Røtterud Jan Harald 
Published: August 2018

Background: The effect of microfracture (MF) or surgical debridement of concomitant full-thickness cartilage lesions in anterior cruciate ligament–reconstructed knees on patient-reported outcomes remains to be determined. Purpose: To evaluate the effect of debridement or MF compared with no surgical treatment of concomitant full-thickness cartilage lesions on patient-reported outcomes 5 years after anterior cruciate ligament reconstruction (ACLR). Study Design: Cohort study; Level of evidence, 2. Methods: Included in this study were 644 patients who were registered in the Norwegian and the Swedish National Knee Ligament Registries from 2005 to 2008 as having undergone unilateral primary ACLR and having a concomitant full-thickness cartilage lesion (International Cartilage Repair Society [ICRS] grades 3-4). Of these patients, 129 were treated with debridement, 164 were treated with MF, and 351 received no surgical treatment simultaneously with ACLR. At 5-year follow-up, 368 (57%) patients completed results on the Knee injury and Osteoarthritis Outcome Score (KOOS). Multivariable linear regression was used to estimate the effect of surgical debridement or MF of concomitant full-thickness cartilage lesions on patient-reported outcomes 5 years after ACLR. Results: Compared with no surgical treatment, there were no unadjusted or adjusted effects of debridement or MF of concomitant full-thickness cartilage lesions on KOOS scores at 5-year follow-up. Conclusion: Compared with leaving concomitant full-thickness cartilage lesions untreated at the time of ACLR, debridement and MF showed no effect on patient-reported outcomes 5 years after surgery.
An open-label phase 1b study of obinutuzumab plus lenalidomide in relapsed/refractory follicular B-cell lymphoma
Authors: Morschhauser Franck , Salles Gilles , Le Gouill Steven , Tilly Herve , Thieblemont Catherine , Bouabdallah Krimo , Fabiani Bettina , Ménard Cédric , Tarte Karin , Cartron Guillaume , Houot Roch 
Published: August 2018

Key PointsOral lenalidomide plus obinutuzumab is well tolerated and effective in patients with R/R FL. The recommended dose of lenalidomide in combination with obinutuzumab 1000 mg was established as 20 mg.
Signaling in the stem cell niche: regulating cell fate, function and plasticity
Authors: Chacón-Martínez Carlos Andrés , Koester Janis , Wickström Sara A. 
Published: August 2018

ABSTRACT
Stem cells have the ability to self-renew and differentiate along multiple lineages, driving tissue homeostasis and regeneration. Paradigms of unidirectional, hierarchical differentiation trajectories observed in embryonic and hematopoietic stem cells have traditionally been applied to tissue-resident stem cells. However, accumulating evidence implicates stemness as a bidirectional, dynamic state that is largely governed by the niche, which facilitates plasticity and adaptability to changing conditions. In this Review, we discuss mechanisms of cell fate regulation through niche-derived cues, with a particular focus on epithelial stem cells of the mammalian skin, intestine and lung. We discuss a spectrum of niche-derived biochemical, mechanical and architectural inputs that define stem cell states during morphogenesis, homeostasis and regeneration, and highlight how these diverse inputs influence stem cell plasticity.
Strategically Designed Zeolitic Imidazolate Frameworks for Controlling the Degree of Graphitization
Authors: Han Sang A , Lee Jaewoo , Shim Kyubin , Lin Jianjian , Shahabuddin Mohammed , Lee Jong-Won , Kim Sang-Woo , Park Min-Sik , Kim Jung Ho 
Published: August 2018

Abstract
The zeolitic imidazolate frameworks (ZIFs) ZIF-8 and ZIF-67 are well-known as belonging to the series of metal-organic frameworks. Using different types of metal ions in them, such as Zn2+ and Co2+ simultaneously, brings both advantages and disadvantages with respect to the carbonization process. For tailoring their properties, we suggest that the best approach involves control of the bimetallic ZIF-derived carbon nanoarchitecture, which is hybridized through the synergistic effects of each metal ion. In this study, the bimetallic ZIFs were designed by controlling the molar ratio of zinc (Zn2+) and cobalt (Co2+) ions, and the carbon nanoarchitecture was subsequently formed by a facile heat treatment and acid leaching. We demonstrate this approach to achieve tailored ZIF derived carbon nanoarchitectures with different pore sizes, surface areas, and degree of graphitization. These pave the way to finding the optimal carbon nanoarchitecture for specific applications such as Li-O2 air cell.
Exercise Timing in Type 2 Diabetes Mellitus: A Systematic Review
Authors: TEO SHAUN Y. M. , KANALEY JILL A. , GUELFI KYM J. , COOK SUMMER B. , HEBERT JEFFREY J. , FORREST MITCHELL R. L. , FAIRCHILD TIMOTHY J. 
Published: August 2018

ABSTRACT

Purpose
The timing of exercise relative to meal consumption has recently been identified as potentially moderating the effectiveness of exercise on glycemic responses in type 2 diabetes mellitus (T2DM). The aim of this study was to systematically review the literature related to exercise timing, relative to meal consumption, and glycemic control in individuals with T2DM.

Methods
Systematic searches in PubMed, EMBASE, CINAHL, Cochrane Library, and ClinicalTrials.gov Registry databases were performed to identify articles published in English from inception to October 2017. Two authors independently extracted data and evaluated the quality of studies using the Cochrane Collaboration Data Collection Form and the Cochrane Collaboration Risk of Bias Assessment Tool, respectively. A qualitative synthesis was performed on the included studies, and results summarized in tables.

Results
Nineteen randomized controlled trials with a total of 346 participants were included. Improvements in glycemia (glucose concentrations and glucose area under the curve) and insulin area under the curve appeared more consistent when exercise was performed during the postmeal period as compared with the premeal period; however, this observation was largely based on indirect comparisons between studies.

Conclusions
There is some evidence from randomized controlled trials that exercise performed 30 min after meal consumption may convey greater improvements in glycemic control for individuals with T2DM. However, there are only two studies that have directly assessed the role of exercise timing on glycemic management, and adopted methodologies are heterogeneous. Future low-risk trials in this field are warranted.
Neuromuscular Fatigue and Recovery after Heavy Resistance, Jump, and Sprint Training
Authors: THOMAS KEVIN , BROWNSTEIN CALLUM GEORGE , DENT JACK , PARKER PAUL , GOODALL STUART , HOWATSON GLYN 
Published: August 2018

ABSTRACT

Purpose
Training methods that require maximal intensity efforts against light and heavy resistance are commonly used for athletic development. Typically, these sessions are separated by at least 48 h recovery on the assumption that such efforts elicit marked fatigue of the central nervous system (CNS), but this posit has not been well studied. The aim of the study was to assess the etiology and recovery of fatigue after heavy-resistance (strength), jump, and sprint training methods.

Methods
Ten male athletes completed three training sessions requiring maximal efforts that varied in their loading characteristics: (i) heavy-resistance exercise (10 × 5 back squats at 80% one-repetition maximum [1RM]) (STR), (ii) jumping exercise (10 × 5 jump squats) (JUMP), and (iii) maximal sprinting (15 × 30 m) (SPR). Preparticipants, postparticipants, and 24-, 48-, and 72-h postparticipants completed a battery of tests to measure neuromuscular function using electrical stimulation of the femoral nerve, and single- and paired-pulse magnetic stimulation of the motor cortex, with evoked responses recorded from the knee extensors. Fatigue was self-reported at each time point using a visual analog scale.

Results
Each intervention elicited fatigue that resolved by 48 (JUMP) and 72 h (STR and SPR). Decrements in muscle function (reductions in the potentiated quadriceps twitch force) persisted for 48 h after all exercise. Reductions in voluntary activation were present for 24 h after JUMP and SPRINT, and 48 h after STR. No other differences in CNS function were observed as a consequence of training.

Conclusion
Strength, jump, and sprint training requiring repeated maximum efforts elicits fatigue that requires up to 72 h to fully resolve, but this fatigue is not primarily underpinned by decrements in CNS function.
A Two-Phase Branch-and-Price-and-Cut for a Dial-a-Ride Problem in Patient Transportation
Authors: Luo Zhixing , Liu Mengyang , Lim Andrew 
Published: August 2018

In this paper, we investigate an extension of the R-DARP recently proposed by [Liu M, Luo Z, Lim A (2015) A branch-and-cut algorithm for a realistic dial-a-ride problem. Transporation Res. Part B: Methodological 81(1):267–288.]. The R-DARP, as a variant of the classic dial-a-ride problem (DARP), consists of determining a set of minimum-distance trips for vehicles to transport a set of clients from their origins to their destinations, subject to side constraints, such as capacity constraints, time window constraints, maximum riding time constraints, and manpower planning constraints. Our problem extends the R-DARP by (1) changing its objective to first maximizing the number of requests satisfied and then minimizing the total travel distance of the vehicles, and (2) generalizing the lunch break constraints of staff members. To solve this problem, we propose a two-phase branch-and-price-and-cut algorithm based on a strong trip-based model. The trip-based model is built on a set of nondominated trips, which are enumerated by an ad hoc label-setting algorithm in the first phase. Then we decompose the trip-based model by Benders decomposition and propose a branch-and-price-and-cut algorithm to solve the decomposed model in the second phase. Our two-phase exact algorithm is tested on the R-DARP benchmark instances and a set of new instances generated according to the same real-world data set as the R-DARP instances. Our algorithm quickly solves all of the R-DARP instances to optimality and outperforms the branch-and-cut proposed by Liu, Luo, and Lim. On the 42 new test instances, our algorithm solves 27 instances to optimality in four hours with the largest instance consisting of 36 requests. The online appendix is available at https://doi.org/10.1287/trsc.2017.0772 .
Framing movement experiences: Migration, materiality and everyday life
Authors: Rosales Marta Vilar 
Published: August 2018

Abstract
This article aims to discuss contemporary migrations from the perspective of material culture. The discussion presented here assumes that material culture plays a significant part in all migration processes by establishing lines of continuity between present and past, confirming and reproducing identity and belonging, framing everyday life and displaying new positioning strategies. Beginning with two snapshots of recent ethnographic fieldwork carried out in Brazil and Canada, I hope to contribute to the discussion of contemporary migration through studying the lens of materiality and the role it plays in these processes. It will be argued that material culture is a productive tool, not only to address the grounds, motivations and resources people activate in order to utilize migration as an effective option, but also to discuss the relationships between movement, settling, cultural reproduction and innovation.
The determining of psychological well-being levels of athletes playing in university teams<p>Üniversite takımlarında oynayan sporcuların psikolojik iyi oluş düzeylerinin belirlenmesi
Authors: Aydın Elif , Birol Sefa Şahan , Temel Veysel 
Published: August 2018

The aim of this project is to determine the psychological well-being of the students who play in Karamanoğlu Mehmetbey University teams in the framework of sub-dimensions according to different variables. The universe of study consist of 214 athletes active in team sports at Karamanoğlu Mehmetbey University in 2017-2018 academic year while the research group consists of 100 athletes. The data were collected using the personal information form prepared by the researcher and the Psychological Well-Being Scale. In the analysis of the data; frequency, Anova, Kruskal Wallis-H significance test and T-Test. As a result of the findings, according to sub-dimensions of psychological well-being; the difference in autonomy sub-dimension in terms of gender change was found statistically significant. There was no significant difference in age, department, family monthly income situation variables. As a result, participants' psychological well-being scores were found to be above average. Extended English summary is in the end of Full Text PDF (TURKISH) file.ÖzetBu çalışmanın amacı, Karamanoğlu Mehmetbey Üniversitesinde, üniversite takımlarında oynayan öğrencilerin psikolojik iyi oluş düzeylerini farklı değişkenlere göre tespit edebilmektir. Yapılan çalışmanın evrenini 2017-2018 akademik yılında Karamanoğlu Mehmetbey Üniversitesi’nin takım sporlarında aktif görev alan 214 sporcu oluştururken, örneklemi 100 sporcu oluşturmaktadır. Veriler araştırmacı tarafından hazırlanan kişisel bilgi formu ve Psikolojik İyi Olma Ölçeği ile toplanmıştır. Verilerin analizinde; frekans, Anova, Kruskal Wallis-H anlamlılık testi ve T-Testi uygulanmıştır. Elde edilen bulgular neticesinde, psikolojik iyi oluşun alt boyutlarına göre; cinsiyet değişkeni açısından özerklik alt boyutunda fark istatistiksel olarak anlamlı bulunurken; yaş, bölüm, aile aylık gelir durumu değişkenlerinde anlamlı bir farklılığa rastlanmamıştır. Sonuç olarak, katılımcıların psikolojik iyi oluş puanlarının ortalamanın üstünde olduğu tespit edilmiştir.
Konflik Etnisitas di Aceh Masa Reformasi, 1998-2005
Authors: Sutrisno Imam Hadi 
Published: August 2018

Sejarah Aceh selalu lekat dengan konflik dengan latar politik baik pada masa kolonial maupun Indonesia kontemporer seperti Perang Aceh, Darul Islam/Tentara Islam Indonesia (DI/TII), dan Gerakan Aceh Merdeka (GAM), tetapi tulisan ini lebih memfokuskan pada konflik dengan latar etnisitas yang muncul pada masa reformasi 1998-2005. Dengan metode sejarah kritis dapat diketahui, bahwa konflik etnisitas di Aceh masa reformasi itu lebih dipengaruhi oleh euphoria reformasi dan menguatnya semangat otonomi daerah yang direpresentasi sebagai ‘kekuasaan’ yang harus ditangan orang daerah-etnik local dan merupakan konflik harisontal sesama warga bangsa dengan latar etnik yang berbeda. Dalam konflik horisontal ini yang cukup menonjol terjadi antara etnik lokal dengan etnik pendatang terutama etnik Jawa yang dianggap telah menguasai etnik local terutama secara ekonomi dan sosiokultural. Sebagai etnik pendatang, orang-orang Jawa di Aceh secara ekonomi lebih maju dibandingkan penduduk local yang notabene berasal dari etnik setempat. Selain itu, secara sosiokultural orang Jawa di Aceh juga menempati posisi social yang penting dan lebih baik dibandingkan dengan penduduk Aceh. Konflik dengan latar etnik di Aceh tentu berbeda dengan konflik dengan latar dan tujuan politik seperti Tengku Daud Beureureh yang memimpin DI/TII, Tengku Hasan Tiro yang memimpin Gerakan Aceh Merdeka/GAM.
ANALISIS MEDAN MAKNA ‘SENI BELA DIRI KHAS JEPANG’ DALAM HURUF KANJI BU (武)
Authors: Irwan Irwan , Mulyadi Mulyadi 
Published: August 2018

(Title: Meaning Field Analysis Of 'Japan's Martial Arts' In Kanji’s Letter Of Bu (武) )This research analyze the kind of words exist in the semantic field of the lexem of kanji BU (武) in Japanese, and how the lexical relation and the semantic feature were formed on each word that exist in one of semantic field. The lexem of kanji BU (武) is literally translated as martial arts, which is general meaning and also has derivatives meaning (hyponim), it creates the semantic field. The type of the research is qualitative research using inter lingual match method. The basic technique method used in this research is the technique of determining element (PUP technique) which applying equal compare connect technique (HBS) and the difference compare connect technique (HBB). The data taken from the book "BUDO: The Martial Ways of Japan" as the primary data, and various articles from scientific journals that discuss the semantic field as supporting data. As the result of the research, found 2 lexems which play role as sub-semantic field of the kanji BU, they are BUJUTSU (武術) and BUDO (武道). Out of the two sub-semantic fields, found 10 words that became hyponim of BUJUTSU and 9 words that became hyponim of BUDO.
Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar
Authors: Ariani Ariani , Anjani Gemala , Sofro Muchlis Achsan Udji , Djamiatun Kis 
Published: August 2018

Background : Sago worm flour (Rhyinchophorus ferrugineus)is a coconut beetle larvae that is processed into flour.This flour contains antioxidants as well as arginine, both of which play a role in modulating oxidative stress including NO involved in immunopathology of cerebral malaria.Objectives : To prove the immunomodulator role of sago worm flour in decreasing circulation NO level at mice who received standard antimalarial therapy Dihydroartemisinin Piperaquine (DHP)Methods : This study was randomized control group post test only design by using 23 Swiss mice which divided into 5 group consist of : K(-) normal mice; K(+) inoculated woth Plasmodium berghei ANKA (PbA); X1 received DHP; X2 received sago worm flour; X3 received both of sago worm flour and DHP. All treatment groups X1,X2 and X3 were inoculated by PbA before treatmen were given. Serum circulation NO level was assessed by ELISA. statistical analysis used was One Way ANOVA followed by Bonferroni post hoc test.Results : The mean NO level in K(-), K(+), X1, X2, and X3 were 1.008 μmol/mL, K(+) 1.338 μmol/mL; while at treatment X1 1.143 μmol/mL, X2 1.410 μmol/mL, dan X3 0.886 μmol/mL. One way ANOVA showed that they were significantly different (p=0.001). Bonferroni post hoc test of X2 was proportional to K(+) (p=1.000), whole had NO level lower than either K(+)(p=0.009) or X2 (p=0.002). Conclusion : The immunomodulatory effects of sago worm flour (Rhyinchophorus ferrugineus) reduced circulating NO levels in standard antimalarial therapy recipients.
Frequency-dependent electro-optics of liquid crystal devices utilizing nematics and weakly conducting polymers
Authors: Garbovskiy Yuriy , Glushchenko Anatoliy 
Published: August 2018

Abstract
Conducting polymer films acting as both electrodes and alignment layers are very promising for the development of flexible and wearable tunable liquid crystal devices. The majority of existing publications report on the electro-optical properties of polymer-dispersed liquid crystals and twisted nematic liquid crystals sandwiched between highly conducting polymers. In contrary, in this paper, electro-optics of nematic liquid crystals placed between rubbed weakly conducting polymers is studied. The combination of weakly conducting polymers and nematics enables a frequency-dependent tuning of the effective threshold voltage of the studied liquid crystal cells. This unusual electro-optics of liquid crystal cells utilizing nematics and weakly conducting polymers can be understood by considering equivalent electric circuits and material parameters of the cell. An elementary model of the observed electro-optical phenomenon is also presented.
Choice of progestogen for endometrial protection in combination with transdermal estradiol in menopausal women
Authors: Mueck Alfred O. , Römer Thomas 
Published: August 2018

Abstract
Transdermal estradiol (TE) application (using gels, patches or a novel spray) is now a preferred route of hormone therapy (HT) in menopausal women, because various risks such as venous thromboembolism, stroke and unwanted hepatic effects can be reduced compared with oral HT. However, in the presence of an intact uterus, concurrent administration of progestogen is needed for endometrial protection. Due to the variety of progestogens available and differences in their clinical effects, the selection of the most appropriate substance and dosing for individual combination therapy can be difficult. This is especially true for TE gels and the novel spray because no fixed combination products are commercially available, meaning all progestogens must be added separately, and even for patches only two transdermal synthetic progestogens are available. The aim of this review was to summarize data on the endometrial effects of the different progestogens and to provide practical recommendations for the choice of progestogen (type and dosing), with a focus on endometrial protection when using TE, especially when using the novel estradiol (E2) spray.