bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’OPECST au travail
Authors: Molinié Marie-Alix , Schultz Emilien 
Published: October 2019

Depuis sa création en 1983, l’OPECST est missionné pour informer le Parlement sur les questions scientifiques et technologiques. Ainsi, le 11 février 2015, l’Office reçoit une saisine pour mener une étude sur les enjeux autours des nouvelles biotechnologies. À travers quelles étapes des parlementaires non-spécialistes s’engagent dans un processus d’enquête pour aboutir à l’écriture d’un rapport final sur un tel sujet ?
Crlz-1 Controls Germinal Center Reaction by Relaying a Wnt Signal to the Bcl-6 Expression in Centroblasts during Humoral Immune Responses
Authors: Choi Seung Young , Pi Joo Hyun , Park Sung-Kyun , Kang Chang Joong 
Published: October 2019

Abstract
Crlz-1 was expressed along with Wnt3a in the rapidly proliferating centroblasts within the dark zone of germinal center (GC) during humoral immune responses. Significantly, Crlz-1 relayed a Wnt/β-catenin signal to the expression of Bcl-6, the master regulator of centroblasts, by mobilizing the cytoplasmic CBFβ into the nucleus to allow Runx/CBFβ heterodimerization and its subsequent binding to the Bcl-6 promoter. The knockdown of Crlz-1 or β-catenin, as well as inhibition of Wnt signaling in the centroblasts, led to the decreased expression of Bcl-6 and, thereby, the altered expression of its various target genes, resulting in their diminished proliferation. Consistently, the administration of Wnt inhibitors into the immunized mice impaired or abolished GC reaction, with concomitant decreases of Crlz-1 and Bcl-6 expression and, thus, centroblastic proliferation. Our observation that Wnt/β-catenin signaling via Crlz-1 regulates GC reaction would suggest developmental strategies for vaccine adjuvants and cancer therapeutics because both immune efficacy and accidental lymphoma depend on GC reaction. Our studies of Crlz-1 were performed using human cell lines, mice, and their primary cells.
Emotion and reasoning in human decision-making
Authors: Rolls Edmund T. 
Published: October 2019

AbstractTwo systems in the brain that are involved in emotional and economic decision-making are described. The first is an evolutionarily old emotion-based system that operates on rewards defined by the genes such as food, warmth, social reputation, and having children. Such decisions are often based on heuristics, such as being highly sensitive to losses, because a single loss might influence one's reproductive success. This is a multidimensional system with many rewards and punishers, all of which cannot be simultaneously optimized. The second route to decision-making involves reasoning, in which it is assumed that utility can be accurately assessed and logical reason can be applied, though the human brain is not naturally computationally good at logical assessment. When decisions are taken, all those factors apply, and in addition there is noise introduced into the system by the random firing times of neurons for a given mean firing rate. The implications for economic decision-making are described. In macroeconomics, it is assumed that the economy behaves like one “representative” agent who can take rational and logical decisions, and who can maximize utility over a constraint. Given the neuroscience of decision-making, the situation is more complex. The utility function may be multidimensional, the reward value along each dimension may fluctuate, the reasoning may be imperfect, and the decision-making process is subject to noise in the brain, making it somewhat random from occasion to occasion. Moreover, each individual has a different set of value functions along each dimension, with different sensitivities to different rewards and punishers, which are expressed in the different personalities of different individuals. These factors underlying the neuroscience of human decision-making need to be taken into account in building and utilizing macroeconomic theories.
Silent Running
Authors: Kermode Mark 
Published: October 2019

A visually stunning and heartfelt riposte to the emotional sterility of Kubrick's 2001: A Space Odyssey, Douglas Trumbull's eco-themed Silent Running (1972) became one of the defining science-fiction films of the seventies. Bruce Dern excels as lonely hero Freeman Lowell, cast adrift in deep space with three robotic 'Drones' who become his 'amazing companions' on a journey 'beyond imagination'.
Mark Kermode, writing on his favourite science fiction film of all time, traces Trumbull's sentimental masterpiece from its roots in the counter-culture of the sixties to its enduring appeal as a cult classic in the 21st century. Drawing on a new interview with Trumbull, Kermode examines both the technical and thematic elements of this uniquely moving space adventure, which continues to be mirrored and imitated by film-makers today.
This special edition features original cover artwork by Olly Moss.
Identification of lard on grilled beef sausage product and steamed beef sausage product using fourier transform infrared (FTIR) spectroscopy with chemometric combination
Authors: Guntarti Any , Ahda Mustofa , Sunengsih Neng 
Published: October 2019

Many issues are spreading about the use of lard in food, one of it is sausage. Sausage is one of the processed foods which are prone of containing pork. In Indonesia, grilled and steamed sausages are popular for children and adults. One of the method which is developed to analyze fat in grilled and steamed sausage products was FTIR spectrophotometry combined with chemometrics. This research aims to develop an analysis method using FTIR spectrophotometry combined with chemometrics to analyze lard content in grilled and steamed beef sausage. Reference sausage made from a mixture of pork and beef. This research was designed by making each 7 concentrations variants of pork and steamed sausage samples (100%, 75%, 65%, 50%, 35%, 25% and 0%). Five samples from market were taken from various beef sausage traders. The fat extraction used n-hexane solvent at the temperature of 70 °C for 5 hours. The extracted fat was analyzed by FTIR spectrophotometry combined with chemometrics. The results of spectrum were analyzed using Horizon MBTM to obtain optimum wave number of steamed sausages in the range of 1000 – 791 cm-1 and grilled sausages in the range of1070 – 796 cm-1. The analysis of steamed sausage with Partial Least Square (PLS) is obtained the equation y = 0.9977x + 0.1166; and the value of R2 0.9977; RMSEC 1.22%; RMSEP 0.22%; and RMSECV 1.26%. The PLS analysis of grilled sausage is obtained the equation y = 0.9972x + 0.1379; and the value of R2 0.9972; RMSEC 1.27%; RMSEP 0.42%; and RMSECV 0.18%. The conclusion of this research is that the FTIR method combined with chemometrics is the proper method for analyzing fat in sausages. The analysis result using Principle Component Analysis (PCA) was obtained from 3 of 5 samples in the market which had the similar physicochemical properties of lard sausage.
EFFECT OF ENVIRONMENT ON BROMOBUTYL RUBBER–STEEL ADHESION
Authors: Sarlin Essi , Rosling Ari , Honkanen Mari , Lindgren Mari , Juutilainen Mira , Poikelispää Minna , Laihonen Paavo , Vippola Minnamari , Vuorinen Jyrki 
Published: October 2019

ABSTRACT
Optimizing the maintenance cycles of rubber-lined components is of great importance. Especially for the industry sectors operating under demanding conditions, challenges in the lifetime evaluation of rubber linings may cause apparent premature failures. Thus, understanding the effect of environmental factors on the performance and durability of rubber linings, as well as on the weakest links of the structure in certain environments, is essential. The performances of bromobutyl rubber and rubber–steel interfaces after exposure to different environments, namely, high temperature (95 °C), moisture (95% relative humidity and immersion), and sulfuric acid (solution with 75 g/L of acid) were investigated. The weakest link of the rubber–metal structure and, consequently, the location of the fracture were mostly within the adhesive layer or at the primer–metal interface. However, the most degraded component of the adhesive system depends on the aging environments.
Four Reflections on a Gestalt Peer Consultation Group
Authors: Aylward Jack , Bowman Charles , Cole Peter , Feder Bud 
Published: October 2019

Abstract
This article describes and explores the benefits of Gestalt Peer Consultation Groups (GPCGs) for Gestalt therapy practitioners. Each of the four authors provides a personal account of his experience with a GPCG in which he participates on an ongoing basis. The authors find that GPCGs can be an essential support to Gestalt therapists in staying emotionally open and in good quality contact with their clients. They also suggest that GPCGs support the therapist's resilience in remaining emotionally available and responsive.A literature review and recommendations for forming GPCGs are presented.
Gestalt Groups 2018 and Beyond: Alternate Tunings Required
Authors: Frew Jon 
Published: October 2019

AbstractGestalt therapy and groups have enjoyed a long and prosperous relationship. It is typical for Gestalt therapists to receive the majority of their instruction, supervision, and mentorship in the “training group” and later to move into a practice, which will involve leading or consulting to a variety of types of groups. The times “they are a changing,” and demographic shifts in the United States prompt a reexamination of the theory and practice of Gestalt therapy in groups. Theoretical concepts outlined by this author in 1997 are revisited and assessed for contemporary fit. Alternate “tunings” are recommended; and also that there be ongoing attention to modifying Gestalt theory and practice, so as to be culturally sensitive to group members today and in the future.
Depression and helplessness impact interstitial cystitis/bladder pain syndrome pain over time
Authors: Crawford Alison , Tripp Dean A. , Nickel J. Curtis , Carr Lesley , Moldwin Robert , Katz Laura , Muere Abi 
Published: October 2019

Introduction: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a devastating urological chronic pelvic pain condition with an unknown etiology. Evidence-based psychological strategies are becoming more successful for symptom management as we learn more about the targets for intervention. Previous research has established an indirect relationship between depression and pain through catastrophizing, but there have yet to be studies examining the emerging role of emotion regulation in this relationship.
Methods: Women with IC/BPS were recruited from tertiary care clinics in Canada and the U.S. between 2013 and 2018. Patients completed questionnaires, including demographics and scores for pain, depression, catastrophizing, and difficulties in emotion regulation at baseline, six months, and one year. Serial mediation was used to test models of pain, catastrophizing, and depression.
Results: A total of 135 women with IC/BPS completed all three time points. The only significant indirect path was from baseline depression to catastrophizing at six months to pain at one year (b=0.10; confidence interval [CI] 0.0049–0.2520). A followup analysis demonstrated that helplessness was the key factor of catastrophizing driving this relationship (b=0.17; CI 0.0282–0.3826).
Conclusions: Reducing feelings of helplessness and increasing patient feelings of control are important ways to limit the effect of low mood on patient pain experience. De-catastrophizing interventions should be part of the referral strategy for IC/BPS symptom management.
A produção audiovisual no ensino fundamental: uma aposta na autoria e coautoria dos estudantes
Authors: Pavão Ana Cláudia Oliveira , Saccol Lilian Roberta Ilha 
Published: October 2019

O presente artigo procura compreender de que modo as produções audiovisuais, por meio das tecnologias educacionais em rede, promovem processos de autoria e coautoria dos estudantes nos anos iniciais do ensino fundamental. Para tanto, realizou-se um estudo exploratório, qualitativo, seguindo o delineamento de pesquisa ação. A observação participante e o questionário de autoavaliação foram adotados como instrumentos de produção de dados neste estudo, que teve como público-alvo, estudantes do quinto ano do ensino fundamental, de uma escola pública do interior do Rio Grande do Sul. A pesquisa foi desenvolvida por meio de propostas pedagógicas entrelaçadas às tecnologias educacionais em rede, especialmente, a produção audiovisual. A análise de conteúdo foi adotada para a interpretação dos dados, apontando a existência de quatro categorias de análise, quais sejam: tecnologias educacionais em rede; autoria e coautoria; produção audiovisual na escola e aprendizagem/desaprendizagem. Como resultado, os estudantes mostraram-se autores e coautores de seu processo de aprendizagem, a partir da criação de produções audiovisuais.
Percepção ambiental e estudantes de enfermagem
Authors: Campos Ana Emília Rosa , Peres Marcelo Cesar Lima , Pereira Bruna Dos Reis 
Published: October 2019

A indissociabilidade entre a saúde e o meio, é essencial para melhor atuação dos enfermeiros, ainda vista na formação como uma temática periférica. A maneira como o aluno percebe o meio ambiente indica como será sua atuação em relação ao cuidado com o meio ambiente e seus impactos na saúde das populações. A forma como o profissional cuida desse meio depende da percepção ambiental que tem do mesmo. Trata se de um estudo de caso, do tipo descritivo com abordagem qualitativa. Objetivo geral: Identificara forma que os alunos de enfermagem percebem o meio ambiente. Foi utilizada a entrevista semiestruturada para coleta de dados. Os resultados indicaram que a percepção ambiental predominante é reducionista, o que pode impactar em suas atuações e responsabilidades sobre este meio. É necessário ultrapassar a percepção reducionista, desde a graduaçãode enfermagem sensibilizando os alunos para agirem de forma responsável com o meio em que vivem e suas ações de promoção a saúde humana.
Multiplexed ISSR genotyping by sequencing distinguishes two precious coral species (Anthozoa: Octocorallia: Coralliidae) that share a mitochondrial haplotype
Authors: Takata Kenji , Taninaka Hiroki , Nonaka Masanori , Iwase Fumihito , Kikuchi Taisei , Suyama Yoshihisa , Nagai Satoshi , Yasuda Nina 
Published: October 2019

Background
Precious corals known as coralliid corals (Anthozoa: Octocorallia) play an important role in increasing the biodiversity of the deep sea. Currently, these corals are highly threatened because of overfishing that has been brought on by an increased demand and elevated prices for them.The deep sea precious corals Pleurocorallium elatius and P. konojoi are distributed in Japanese waters and have distinct morphological features: (1) the terminal branches of the colony form of P. elatius are very fine, while those of P. konojoi are blunt and rounded, (2) the autozooids of P. elatius are arranged in approximately four rows, while those of P. konojoi are clustered in groups. However, previous genetic analysis using mtDNA and nuclear DNA did not indicate monophyly. Therefore, it is important to clarify their species status to allow for their conservation.

Methodology
We collected a total of 87 samples (60 of Corallium japonicum and 27 of P. konojoi) from around the Ryukyu Islands and Shikoku Island, which are geographically separated by approximately 1,300 km. We used a multiplexed inter-simple sequence repeat (ISSR) genotyping by sequencing (MIG-seq) and obtained 223 SNPs with which to perform STRUCTURE analysis and principle coordinate analysis (PCoA). In addition, two relatively polymorphic mtDNA regions were sequenced and compared.

Results
P. elatius and P. konojoi share a same mtDNA haplotype, which has been previously reported. However, MIG-seq analysis clearly distinguished the two species based on PCoA and STRUCTURE analysis, including 5% of species-specific fixed SNPs.

Conclusion
This study indicated that P. elatius and P. konojoi are different species and therefore both species should be conserved separately. Our findings highlight the importance of the conservation of these two species, especially P. elatius, whose population has been dramatically depleted over the last 100 years. The study also demonstrated the effectiveness and robustness of MIG-seq for defining closely related octocoral species that were otherwise indistinguishable using traditional genetic markers (mtDNA and EF).
Reference Interval of Glycated Hemoglobin in Adults in Port Harcourt, Nigeria
Authors: Igila Allison Frederick , Aaron C. Ojule 
Published: October 2019

Background: Measurement of glycated haemoglobin is accepted as the gold standard for the diagnosis and management of diabetes mellitus; but it is rarely used in this environment, a resource-poor setting, largely due to the high cost of the assay. There is need to determine its reference intervals in Port-Harcourt and encourage the use of this assay.
Aim:This study was designed to determine the reference interval of glycated haemoglobin of apparently healthy subjects between the ages of 20-80 years in Port Harcourt, Rivers State, Nigeria.
Methods: A total of 172 subjects who met the inclusion criteria were recruited for the study. A cross sectional sampling method was used to recruit subject. Subjects’ past medical history, demographic and anthropometric information were obtained with the help of a questionnaire. Blood was collected from subjects into an EDTA bottle and analysed for glycated haemoglobin using the boronate affinity chromatographic method.
Results: Results were analyzed using Statistical Package for Social Sciences version 20.0 (SPSS 20.0) and the reference interval was determined by the nonparametric method due to the skewness of the data. The mean age of subjects was 35.4 years and the minimum and maximum glycated haemoglobin value obtained were 3.5% and 6.0% after eliminating outliers. This gave a mean glycated haemoglobin value of 4.84% and a reference interval of 4.0-5.9%.
Conclusion: The reference interval so determined (4.0-5.9%) is different from that generated by the manufacturer of the diagnostic kit(4.0-6.5%). The introduction of this new local reference interval will enhance patient management in our local hospitals.
Dilution Ratio and Pasteurization Effects on the Physico-chemical Characteristics of the Pulp of Saba senegalensis of Côte d'Ivoire
Authors: Kouakoua Yapi Elisée , Coulibaly Aïssatou , Degbeu Kouadio Claver , Amani N’Guessan Georges 
Published: October 2019

Aims: The objective of this study was to evaluate the effect of dilution ratio and pasteurization on physico-chemical parameters of Saba senegalensis pulp in the context of its recovery.
Study Design: The experimental set-up was of a completely randomized design.
Place and Duration of Study: This study was carried out in the Department of Food Science and Technology, at the Laboratory of Food Biochemistry and Tropical Product Technology (BATPTL) of Nangui Abrogoua University, Abidjan, Côte d'Ivoire, between June and August 2019.
Methodology: The pulp collected from the fruit was diluted according to the following pulp/water ratio (RPW; v/v): 1:0.5; 1:1 and 1:1.5 and pasteurized at 75°C at different times (5 min, 10 min and 15 min). The pH, titratable acidity (TA), Total soluble solid (TSS), vitamin C, β-carotene and the colour were determined on the different samples.
Results: The results obtained during this study showed that all the physico-chemical parameters evaluated, except pH, are affected during dilution while during pasteurization only vitamin C and β-carotene are affected. During the respective dilutions, 50%, 62% and 66% of the vitamin C concentration decreased as well as 53%, 74% and 76% of β-carotene. It also led to a decrease in total soluble solid (TSS) of 32%, 50% and 59%. Following the pasteurization of each diluted pulp12%, 45% and 50% on average of the vitamin C are lost at the respective pasteurization time (5 min, 10 min and 15 min respectively). For β-carotene the content decreases (50%) within the first 5 minutes and remains constant during the last 10 minutes of pasteurization.
Conclusion: During Saba senegalensis fruit processing into nectar, dilution and pasteurization factors must be considered in order to ensure the physico-chemical quality of the beverage. The physico-chemical characteristics were more affected during dilution than in pasteurization.
Traditionally Used Anti-hepatitis Plants Species in Dakar District, Senegal
Authors: Diatta Kady , Diatta William , Fall Alioune Dior , Dieng Serigne Ibra Mbacké , Mbaye Amadou Ibrahima , Fall Paulèle Aynina 
Published: October 2019

Viral etiologies especially viral hepatitis B remain an area of concern sub-Saharan Africa with a variable prevalence between countries. Ethnobotanical knowledge of medicinal plants used in the treatment of viral hepatitis, in particular, viral hepatitis B, was conducted in the District of Dakar (Senegal). Forty-two participants were surveyed, which included 18 herbalists, 19 Traditional medicine practitioners (TMPs)and 5 resource persons. Fifty-one plant species were documented from forty-seven genera and thirty families. The most frequently mentioned families were; Fabaceae (11 species); Meliaceae, (4 species); Rubiaceae and Combretaceae (3 species each); Annonnacaea, Malvaceae, Rutaceae and Asteraceae (2 species each). All other families were represented by a single species. The decoction was the most common method of préparation (66.66%). Leaves and trunk bark were the plant parts of the plant most used. The most commonly used species were: Tinospora bakis (85.71%), Gardiena ternifolia (73.8%), Calotropis procera (71.42%), Carica papaya (66.66%), Citrus aurantifolia (64.28%) and Cochlospermum tinctorium (61.9%). It is concluded that the hepatoprotective properties of these plants are certainly induced by chemical compounds that will have to be identified later through phytochemical research.
Characterization of Antifungal Volatile Organic Compounds Produced by Bacterial Endophytes against Fusarium oxysporum through GC-MS Analysis
Authors: Muthulakshmi P. , Thangavel Suganya , Seethapathy Parthasarathy 
Published: October 2019

Banana (Musa spp.) is one of the most important fruit crops cultivated throughout the world. Fusarium wilt caused by the fungus, Fusarium oxysporum f. sp. cubense (E.F. Smith) Snyder & Hansen (Foc) causes significant threats to banana production. Endophytic bacteria play a significant role in plant protection against soil borne plant pathogens and promote overall productivity of agricultural ecosystems. Secondary metabolites produced by several species of Bacillus have been found to possess antibacterial or antifungal activity against different isolates of Fusarium oxysporum f. sp. cubense. These were identified by crude tests using agar gel diffusion and GC-MS analysis of the fungal crude extracts. Understanding of the metabolites produced by endophytes is also important in the context of biological control of soil-borne diseases of banana. GC-MS analysis of crude antibiotic extracts of bacterial endophytic isolates viz., GNBS3, PVBS3, NPBS4, KVBS4, BS1, revealed DL-Proline,5 Oxo as the major compound. Having both antifungal and antibacterial activity.