bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insektengiftallergie: Die am häufigsten zum Tode führende Anaphylaxie
Authors: Sieber Wolfgang , Brunner Monika 
Published: July 2019

Was ist neu?
Diagnostik der Insektengiftallergien Die rekombinanten Antikörper rApi m1, rApi m3 und rApi m10 bei Bienengiftallergie sowie rVes v5 und rVes v1 bei Wespengiftallergie haben sich in der Diagnostik etabliert und dienen auch zur Unterscheidung, ob eine Bienen- oder Wespengiftallergie vorliegt bei Patienten, die nicht genau wissen, von welchem Insekt sie gestochen wurden.
Therapie der Insektengiftallergie Die Hyposensibilisierung ist die Methode der Wahl zur Behandlung der Insektengiftallergie. Bei Patienten mit schwerer anaphylaktischer Reaktion, besonders bei Bienengift und hoher Exposition wie bei Imkern, sollte die Dosis primär schon 200 µg betragen.
Lebensqualität nach Insektengift-Hyposensibilisierung Die Hyposensibilisierung und deren Erfolgsbeurteilung durch den Patienten nimmt immer mehr Einfluss auf die Lebensqualität. Gerade durch die Stichprovokation wird eine Verbesserung der Lebensqualität erreicht.
Sarcoidosis al descubierto: Lo que deberíamos informar en las imágenes torácicas
Authors: Martínez Martínez Javier Mauricio , Palacio Vargas Karen Margarita , Astorga Lahoz María del Mar , Conde Blanco Manuel , Ferrario María Cecilia , Aguirre Pablo Matías 
Published: July 2019

La sarcoidosis es una enfermedad granulomatosa no caseificante, multisistémica, de causa desconocida, que compromete al pulmón y a los ganglios linfáticos mediastinales entre el 90 y el 95% de los casos. También puede afectar otros órganos, como las glándulas salivales, piel, ojos, hígado, bazo, corazón, huesos y sistema nervioso central. La sarcoidosis tiene una baja prevalencia en Latinoamérica y es subdiagnosticada debido a la alta frecuencia de otros trastornos similares, como tuberculosis, lepra y micosis profundas.El diagnóstico presuntivo se establece con hallazgos imagenológicos característicos dentro de un contexto clínico apropiado y se confirma con la evidencia histológica de granulomas no caseificantes de células epiteliales, en ausencia de otras etiologías.Los hallazgos torácicos incluyen la afectación pulmonar, ganglionar y bronquial, los cuales son detectados a través de la radiografía (Rx) y tomografía computada (TC) de tórax, siendo esa última más sensible y específica.En este artículo, resaltamos la importancia de reconocer los patrones de presentación típicos y atípicos de la sarcoidosis en Rx y TC, así como la relevancia de las imágenes torácicas como elemento clave en el algoritmo diagnóstico de esa patología. También describimos la utilidad de la resonancia magnética (RM), como método adicional para el diagnóstico en casos de afectación cardíaca y el papel de la tomografía por emisión de positrones (PET-CT) en el seguimiento terapéutico.
Placental Findings in Postpartum Preeclampsia: A Comparative Retrospective Study
Authors: Ditisheim Agnès , Sibai Baha , Tatevian Nina 
Published: July 2019

Abstract
Objective Preeclampsia is a multifactorial placental disease that can occur after delivery. The pathophysiology of postpartum preeclampsia remains unknown. The objective was to describe placental findings in postpartum preeclampsia.
Study Design This is a case–control study, comparing the placental histologic findings in four groups of 30 patients with postpartum preeclampsia, early-onset preeclampsia, late-onset preeclampsia, and normotensive controls.
Results Placentas of postpartum preeclampsia had a mean placental weight not different from that of late-onset preeclampsia at a similar gestational age (479.0 ± 152.7 vs. 521.3 ± 144.1 g, p = 0.07); they showed a higher rate of acute deciduitis of 42.4% than early preeclampsia (5.7%, p < 0.01) or in controls (3.2%, p < 0.01); 18.2% had decidual arteriolopathy, with no significant difference with other groups. These placentas had fewer villous infarcts as compared with early preeclampsia (9.1 vs. 62.9%, p < 0.01) and less accelerated maturation of villi (24.2 vs. 74.3%, p < 0.01).
Conclusion There were no significant differences for decidual arteriolopathy and villous infarcts among postpartum preeclampsia, late-onset preeclampsia, and the controls. This suggests that postpartum preeclampsia is more of a maternal disease in which the placenta may act as a priming effect in predisposed mothers and becomes clinically apparent after delivery.
Schwannoma: A Rare Hoffa's Fat Pad Tumor
Authors: Caballero Martel Jonathan Ruben , Estévez Sarmiento Sara 
Published: July 2019

AbstractHoffa's fat pad can be affected by a variety of tumors. Schwannomas are benign and typically solitary neoplasms of the peripheral nerve sheath; they are made up of the neoplastic Schwann cells and are usually located eccentrically. Malignant schwannomas are extremely uncommon. Here we report a case of an intra-articular schwannoma of the knee. A 54-year-old man presented with a painful lump in the medial aspect of the knee. Magnetic resonance imaging revealed a well-circumscribed intra-articular mass, which was later diagnosed as an intra-articular schwannoma based on biopsy findings.
Effect of Low-Level Laser Therapy versus Electroacupuncture on Postnatal Scanty Milk Secretion: A Randomized Controlled Trial
Authors: Maged Ahmed M. , Hassanin Marwa E. , Kamal Wafaa M. , Abbassy Amr H. , Alalfy Mahmoud , Askalani Ahmed N. , El-Lithy Ahmed , Nabil Mohamed , Farouk Dalia , Hussein Eman A. , Hammad Bahaa 
Published: July 2019

Abstract
Objective Postnatal scanty milk secretion is a common complaint. Some physical and medical interventions were advocated to help milk production. These interventions should be effective and safe for the mother and the infant. This study aimed to compare the effects of low-level laser therapy and electroacupuncture on postnatal scanty milk secretion.
Study Design A randomized controlled study conducted on 60 healthy primiparous mothers with insufficient lactation. They were randomly divided into three equal groups: group A (control), group B (those who received low-power He–Ne laser beam on both breasts), and group C (those who received faradic current stimulation at Spleen 6, Liver 3, and Small Intestine 1 acupuncture points on both sides). All participants received 10 mg Domperidone three times a day and were given advice about lactation, nutrition, and fluid intake. Evaluation was done before and after the treatment program.
Results The mean serum prolactin, infant weight, and visual analog scale (VAS) score were significantly increased in the three groups posttreatment when compared with their corresponding levels pretreatment. Posttreatment serum prolactin was significantly elevated in group C more than the other two groups (p = 0.001 and 0.012, respectively). Also, it was significantly elevated in group B more than in group A (p = 0.001). The mean value of infant weight was significantly elevated in group C when compared with its corresponding values in both groups A (p = 0.001) and B (p = 0.029). The VAS score was significantly increased in both groups B and C when compared with group A (p = 0.001).
Conclusion Electroacupuncture is more effective than low-level laser therapy in increasing postnatal scanty milk secretion.
Clinical Trial Registration NCT03806062.
Risks and Benefits of Anticoagulation in Cancer and Noncancer Patients
Authors: Park Deborah Y. , Khorana Alok A. 
Published: July 2019

AbstractVenous thromboembolism (VTE) is a common complication of cancer occurring in up to one-fifth of cancer patients. The risk of VTE, which includes deep venous thrombosis (DVT) and pulmonary embolism (PE), is increased up to seven-fold in patients with cancer. While the indications and contraindications to treatment for VTE patients with cancer parallel to those patients without cancer, the treatment of VTE is challenging for cancer patients who are three-fold more likely to have VTE recurrence than patients without cancer and who are also at increased risk of bleeding. While anticoagulant therapy is recommended for most cancer patients with VTE, some patients may benefit from alternative interventions, such as thrombolysis, thromboembolectomy, or placement of an inferior vena cava (IVC) filter. Recent data support the use of direct oral anticoagulants (DOACs) for treatment of cancer-associated VTE in select cancer patients and for primary prevention of thromboembolism in high-risk cancer patients. Individualized decision-making, keeping in consideration the patient's risk for thrombotic and bleeding events is essential.
The Reporting Quality of Randomized Controlled Trial Abstracts in Plastic Surgery
Authors: Gallo Lucas , Wakeham Scott , Dunn Emily , Avram Ronen , Thoma Achilleas , Voineskos Sophocles 
Published: July 2019

Abstract

Background
When evaluating randomized controlled trials (RCTs), clinicians will often refer to the abstract for an initial assessment of the results and to determine whether a full-text review is warranted.

Objectives
This project aims to assess the reporting quality of RCT abstracts published within the top 5 plastic surgery journals utilizing the Consolidated Standards of Reporting Trials (CONSORT) for abstracts checklist.

Methods
A computerized database search of OVID MEDLINE was performed. All primary RCTs published within the top 5 plastic surgery journals (by 2016 International Scientific Indexing impact factor) from 2011 to 2018 were included. Two reviewers, blinded to journal and author, independently and in duplicate, scored abstracts employing the 16-item CONSORT for abstracts checklist.

Results
This review identified 126 RCTs that satisfied the inclusion criteria. Included studies were distributed across 5 journals: Plastic and Reconstructive Surgery (n = 83), JAMA Facial Plastic Surgery (n = 8), Aesthetic Surgery Journal (n = 33), Journal of Reconstructive Microsurgery (n = 2), and the Journal of Hand Surgery–European Volume (n = 0). Mean overall item adherence across all abstracts was 7 (SD ± 2). The most poorly reported items were “trial registration,” “method of randomization,” and “source of trial funding” and appeared in 4%, 2.4%, and 0% of abstracts, respectively.

Conclusions
There is limited adherence to the CONSORT for abstracts checklist among RCT abstracts published within the top 5 plastic surgery journals. Given the reliance of clinicians on abstract reporting, omitting essential trial details can lead to an inaccurate interpretation of trial results and improper application in clinical practice. Active endorsement of the CONSORT for abstracts checklist is required to improve the quality of RCT abstract reporting.
Pattern recognition receptor-mediated innate immune responses in seminal vesicle epithelial cell and their impacts on cellular function†
Authors: Gong Maolei , Wang Fei , Liu Weihua , Chen Ran , Wu Han , Zhang Wenjing , Yu Xiaoqin , Han Ruiqin , Liu Aijie , Chen Yongmei , Han Daishu 
Published: July 2019

Abstract
The seminal vesicles can be infected by microorganisms, thereby resulting in vesiculitis and impairment in male fertility. Innate immune responses in seminal vesicles cells to microbial infections, which facilitate vesiculitis, have yet to be investigated. The present study aims to elucidate pattern recognition receptor–mediated innate immune responses in seminal vesicles epithelial cells. Various pattern recognition receptors, including Toll-like receptor 3, Toll-like receptor 4, cytosolic ribonucleic acid, and deoxyribonucleic acid sensors, are abundantly expressed in seminal vesicles epithelial cells. These pattern recognition receptors can recognize their respective ligands, thus activating nuclear factor kappa B and interferon regulatory factor 3. The pattern recognition receptor signaling induces expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha (Tnfa) and interleukin 6 (Il6), chemokines monocyte chemoattractant protein-1 (Mcp1) and C–X–C motif chemokine 10 (Cxcl10), and type 1 interferons Ifna and Ifnb. Moreover, pattern recognition receptor-mediated innate immune responses up-regulated the expression of microsomal prostaglandin E synthase and cyclooxygenase 2, but they down-regulated semenogelin-1 expression. These results provide novel insights into the mechanism underlying vesiculitis and its impact on the functions of the seminal vesicles.
Synergistic inhibition of csal1 and csal3 in granulosa cell proliferation and steroidogenesis of hen ovarian prehierarchical development†
Authors: Zhu Hongyan , Qin Ning , Xu Xiaoxing , Sun Xue , Chen Xiaoxia , Zhao Jinghua , Xu Rifu , Mishra Birendra 
Published: July 2019

AbstractSALL1 and SALL3 are transcription factors that play an essential role in regulating developmental processes and organogenesis in many species. However, the functional role of SALL1 and SALL3 in chicken prehierarchical follicle development is unknown. This study aimed to explore the potential role and mechanism of csal1 and csal3 in granulosa cell proliferation, differentiation, and follicle selection within the prehierarchical follicles of hen ovary. Our data demonstrated that the csal1 and csal3 transcriptions were highly expressed in granulosa cells of prehierarchical follicles, and their proteins were mainly localized in the cytoplasm of granulosa cells and oocytes as well as in the ovarian stroma and epithelium. It initially revealed that both csal1 and csal3 may be involved in chicken prehierarchical follicle development via a translocation mechanism. Furthermore, our results showed an abundance of CCND1, Bcat, StAR, CYP11A1, and FSHR mRNA in granulosa cells, and the proliferation levels of granulosa cells from the prehierarchical follicles were significantly increased by siRNA-mediated knockdown of csal1 or/and csal3. Conversely, the overexpression of csal1 or/and csal3 in the granulosa cells led to a remarkably decreased of them. Moreover, csal1 and csal3 together exert a much stronger effect on the regulation than any of csal1 or csal3. These results indicated that csal1 and csal3 play synergistic inhibitory roles on granulosa cell proliferation, differentiation, and steroidogenesis during prehierarchical follicle development in vitro. The current data provide a basis of molecular mechanisms of csal1 and csal3 in controlling the prehierarchical follicle development and growth of hen ovary in vivo.
Functional Diversity: An Epistemic Roadmap
Authors: Malaterre Christophe , Dussault Antoine C , Mermans Ely , Barker Gillian , Beisner Beatrix E , Bouchard Frédéric , Desjardins Eric , Handa I Tanya , Kembel Steven W , Lajoie Geneviève , Maris Virginie , Munson Alison D , Odenbaugh Jay , Poisot Timothée , Shapiro B Jesse , Suttle Curtis A 
Published: July 2019

AbstractFunctional diversity holds the promise of understanding ecosystems in ways unattainable by taxonomic diversity studies. Underlying this promise is the intuition that investigating the diversity of what organisms actually do (i.e., their functional traits) within ecosystems will generate more reliable insights into the ways these ecosystems behave, compared to considering only species diversity. But this promise also rests on several conceptual and methodological (i.e., epistemic) assumptions that cut across various theories and domains of ecology. These assumptions should be clearly addressed, notably for the sake of an effective comparison and integration across domains, and for assessing whether or not to use functional diversity approaches for developing ecological management strategies. The objective of this contribution is to identify and critically analyze the most salient of these assumptions. To this aim, we provide an epistemic roadmap that pinpoints these assumptions along a set of historical, conceptual, empirical, theoretical, and normative dimensions.
Assessing the molecular diversity of Hildaea (Poaceae, Panicoideae): reaching a compromise between the splitter and the lumper
Authors: Silva Christian , Snak Cristiane , Davidse Gerrit , Van Den Berg Cássio , Oliveira R Patrícia 
Published: July 2019

AbstractThe taxonomy of some groups of plants is challenging, and the strict use of morphological characters may not be enough to solve problems of species delimitation. Hildaea, a genus of tropical grasses recently segregated from Ichnanthus section Foveolatus, is mostly composed of species with obscure boundaries. This group was revised by two authors, Rogers and Stieber, with distinct opinions. The former recognized &gt; 30 taxa, whereas the latter reduced this number to six. In the present study, we re-evaluate current and previous classifications through a comprehensively sampled phylogenetic analysis using plastid (ndhF) and nuclear data (ETS and ITS). Our results demonstrate that the diversity in Hildaea is a middle ground between the splitter and the lumper, indicating that several taxa currently treated as synonyms should be reinstated. Old World Hildaea were found to belong to two clades, one including species from Asia and Oceania, and another including species from the Neotropics and from western Africa. Topological incongruences suggest that hybridization may be a possible cause for the morphological variation observed and also an important evolutionary driver.
Continuous Leakage-Resilient Certificate-Based Encryption Scheme Without Bilinear Pairings
Authors: Zhou Yanwei , Yang Bo , Wang Tao , Xia Zhe , Hou Hongxia 
Published: July 2019

Abstract
Recently, much attention has been focused on designing provably secure cryptographic primitives in the presence of key leakage, even the continuous leakage attacks. However, several constructions on the (continuous) leakage-resilient certificate-based encryption (CBE) scheme were proposed based on the bilinear pairings, and the corresponding computational efficiency is lower. Also, the leakage on the master secret key is omitted in the previous constructions. In this paper, to further achieve the better performance, a new construction method of continuous leakage-resilient CBE scheme without bilinear pairings is proposed, and the chosen-ciphertext attacks security of designed scheme is proved based on the hardness of the classic decisional Diffie–Hellman assumption. The performance analysis shows that our method not only can obtain higher computational efficiency but also enjoys better security performances, such as the leakage parameter of secret key of user has the constant size, and an adversary cannot obtain any leakage on the secret key of user from the corresponding given ciphertext etc. The advantage is that our proposal allows leakage attacks of multiple keys, i.e. continuous leakage resilience of the secret key of user and bounded leakage resilience of the master secret key. Additionally, to provide the leakage resilience for the cloud computing, a novel data access control scheme for cloud storage service is proposed from our continuous leakage-resilient CBE scheme, which can keep its claimed security in the leakage seting.
PM2.5 concentration in the ambient air is a risk factor for the development of high-risk coronary plaques
Authors: Yang Seokhun , Lee Seung-Pyo , Park Jun-Bean , Lee Heesun , Kang Si-Hyuck , Lee Sang-Eun , Kim Juyong Brian , Choi Su-Yeon , Kim Yong-Jin , Chang Hyuk-Jae 
Published: July 2019

Abstract

Aims
We aimed to investigate whether long-term exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) in the ambient air is related to the development or growth of coronary plaques.

Methods and results
This study involved 364 residents of Seoul, Korea, who underwent serial coronary computed tomographic angiography (CCTA) at an interval of ≥2 years. Each participant’s average concentration of residential PM2.5 between the two CCTAs was calculated. Primary endpoint was the development of high-risk plaque (HRP), defined as a plaque with low attenuation, spotty calcium, and positive remodelling. Secondary endpoints were the volume increase of total plaque and its component volume. Among those without HRP at baseline (n = 341), 20 patients developed HRP at follow-up CCTA, the residential PM2.5 concentration of which was significantly higher than those without HRP at follow-up (25.8 ± 2.0 vs. 25.0 ± 1.7 μg/m3 for patients with newly developed HRP vs. patients without HRP at follow-up; P = 0.047). An increase in PM2.5 concentration was associated with increased incidence of HRP at follow-up [adjusted hazard ratio (aHR) 1.62, 95% confidence interval (CI) 1.22–2.15, P < 0.001]. In a secondary analysis, the PM2.5 concentration was associated with an increased risk of the formation of either fibrofatty or necrotic core component in newly developed plaques (aHR 1.41, 95% CI 1.23–1.61, P < 0.001), and with a higher risk of total plaque volume progression in the pre-existing plaques (aHR 1.14, 95% CI 1.05–1.23, P = 0.002).

Conclusion
Exposure to higher concentration of PM2.5 in the ambient air is significantly associated with the development of high-risk coronary plaques.
Thromboembolic events around the time of cardioversion for atrial fibrillation in patients receiving antiplatelet treatment in the ACTIVE trials
Authors: McIntyre William F , Connolly Stuart J , Wang Jia , Masiero Simona , Benz Alexander P , Conen David , Wong Jorge A , Beresh Heather , Healey Jeff S 
Published: July 2019

Abstract

Aims
It is unknown whether cardioversion of atrial fibrillation causes thromboembolic events or is a risk marker. To assess causality, we examined the temporal pattern of thromboembolism in patients having cardioversion.

Methods and results
We studied patients randomized to aspirin or aspirin plus clopidogrel in the ACTIVE trials, comparing the thromboembolic rate in the peri-cardioversion period (30 days before until 30 days after) to the rate during follow-up, remote from cardioversion. Among 962 patients, the 30-day thromboembolic rate remote from cardioversion was 0.16%; while it was 0.73% in the peri-cardioversion period [hazard ratio (HR) 4.1, 95% confidence interval (CI) 2.1–7.9]. The 30-day thromboembolic rates in the periods immediately before and after cardioversion were 0.47% and 0.96%, respectively (HR 2.2, 95% CI 0.7–7.1). Heart failure (HF) hospitalization increased in the peri-cardioversion period (HR 11.5, 95% CI 6.8–19.4). Compared to baseline, the thromboembolic rate in the 30 days following cardioversion was increased both in patients who received oral anticoagulation or a transoesophageal echocardiogram prior to cardioversion (HR 7.9, 95% CI 2.8–22.4) and in those who did not (HR 4.8, 95% CI 1.6–14.9) (interaction P = 0.2); the risk was also increased with successful (HR 4.5; 95% CI 2.0–10.5) and unsuccessful (HR 10.2; 95% CI 2.3–44.9) cardioversion.

Conclusions
Thromboembolic risk increased in the 30 days before cardioversion and persisted until 30 days post-cardioversion, in a pattern similar to HF hospitalization. These data suggest that the increased thromboembolic risk around the time of cardioversion may not be entirely causal, but confounded by the overall clinical deterioration of patients requiring cardioversion.