bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photo‐Induced Fluorescence Discoloration of Carbon Dots for Advanced Dynamic Information Encryption
Authors: Liao Junfei , Wu Mengyi , Li Jiurong , Gong Xiao 
Published: November 2024

AbstractThe fluorescence discoloration of carbon dots (CDs) induced by UV irradiation without chemical modification has proved to be difficult to achieve. Herein, the synthesis of UV‐sensitive CDs with photo‐induced discoloration is reported using a heteroatom co‐doped hydrothermal method and the fluorescence of the red‐emitting CDs (R‐CDs) can be tuned under UV irradiation from red to yellow to green, showing a new strategy for simpler and easier modulating the luminescence of CDs. The UV‐induced fluorescence color change of CDs involves the changes of molecular fluorophores and oxygen defects on the surface of CDs under UV irradiation. Results show that the photo‐induced fluorescence discoloration of CDs results in the transformation of part of the internal groups, such as C─O and CO. Based on the unique UV‐induced fluorescence color‐changing property of the R‐CDs, a UV‐sensing film is fabricated, which is expected to be further applied in the field of UV detection. Furthermore, by combining CDs fluorescent ink with binary code and Morse code, it can encrypt and decrypt the information of specific text. This new concept of photo‐induced fluorescence discoloration in CDs provides strong technical support for the next generation of advanced information encryption.
Stabilization of cuσ+ via strong Cu‐O‐Si interface for efficient electrocatalytic acetylene semi‐hydrogenation
Authors: Jiang Xiaoli , Ge Wangxin , Fan Yu , Sheng Xuedi , Jiang Hongliang , Li Chunzhong 
Published: November 2024

AbstractThe development of a high‐performance electrocatalytic acetylene semi‐hydrogenation catalyst is the key to the selective removal of acetylene from industrial ethylene gas and non‐oil route to ethylene production. However, it is still hampered by the deactivation of the catalyst and hydrogen evolution interference. Here, we proposed an interface engineering strategy involving the Cu and cupric oxide nanoparticles dispersed on amorphous SiO2 (Cu/CuOx/SiO2) by a simple stöber method. x‐ray photoelectron spectroscopy demonstrated the strong interfacial interaction between cupric oxide nanoparticles and SiO2. The formed Cu‐O‐Si interface stabilized the Cuσ+ at high reduction potentials, thus improving the activity and stability of the acetylene reduction reaction, as confirmed by in situ Raman spectroscopy. Consequently, the electrochemical test results showed that at 0.5 M KHCO3, the maximum Faraday efficiency (FE) of ethylene on the optimized Cu/CuOx/SiO2 reached 96%. And ethylene FE remains above 85% at −100 mA cm−2 for 40 h.
Pollinator functional group abundance and floral heterogeneity in an agroecological context affect mating patterns in a self‐incompatible wild plant
Authors: Labonté Audrey , Le Corre Valérie , Matejicek Annick , Felten Emeline , Turpin Mélinda , Laurent Emilien , Michel Séverine , Ducourtieux Chantal , Vieren Eric , Proesmans Willem , Deytieux Violaine , Cordeau Stéphane , Vanbergen Adam J. 
Published: November 2024

AbstractPremiseRestoration of seminatural field margins can elevate pollinator activity. However, how they support wild plant gene flow through interactions between pollinators and spatiotemporal gradients in floral resources remains largely unknown.MethodsUsing a farm‐scale experiment, we tested how mating outcomes (expected heterozygosity and paternity correlation) of the wild, self‐incompatible plant Cyanus segetum transplanted into field margins (sown wildflower or grass‐legume strips) were affected by the abundance of different pollinator functional groups (defined by species traits). We also investigated how the maternal plant attractiveness, conspecific pollen donor density, and heterospecific floral richness and density interacted with pollinator functional group abundance to modulate C. segetum mating outcomes.ResultsMultiple paternity increased (=lower paternity correlation) with greater local abundance of hoverflies (syrphids) and female medium‐sized wild bees (albeit the latter's effect diminished with decreasing maternal plant attractiveness), and the presence of male bumblebees (Bombus) under low local floral richness. Cyanus segetum progeny genetic diversity increased with male Bombus presence but decreased with greater abundance of syrphids and honey bees (Apis mellifera).ConclusionsOverall, field margins supported plant‐pollinator interactions ensuring multiple paternity and conservation of allelic diversity in C. segetum progeny. The contribution to plant mating outcomes of different pollinator functional groups was dictated by their local abundance or traits affecting pollen transfer efficiency. The local floral richness or maternal plant attractiveness sometimes modulated these relationships. This complex response of wild plant mating patterns to community interactions has implications for the use of field margins to restore functional pollination systems in farmed landscapes.
Electrochemical/Cobalt Dual Catalysis for Regioselective Tetramerization of Indoles
Authors: Liu Kuan‐Te , Hung Yu‐Lin , Jhang Kai‐Wun , Chen Hung‐Chi , Li Hung‐Li , Chiang Chien‐Wei 
Published: November 2024

AbstractIndoles are critically important heterocyclic building blocks with broad applications in pharmaceuticals, fragrances, agrochemicals, pigments, and materials. Recent advancements have highlighted bis‐indole derivatives and oligomerized indoles as promising scaffolds for anticancer compounds and materials in organic semiconductors. Despite the challenges in forming C−C bonds in indoles, we developed a novel method combining electrochemical and cobalt complex dual catalysis to achieve regioselective C3−C3/C2−C3 coupling. Using 1‐methylindole as a model substrate, we optimized reaction conditions to achieve a 90 % yield of the tetramerized product. The method proved effective for various substituted indoles, with satisfactory yields for 6‐position substituents and poorer results for 5‐position due to steric hindrance, as confirmed by DFT calculations. The proposed mechanism involves initial C3−C3 coupling facilitated by cobalt catalysis, followed by C2−C3 coupling under electrochemical conditions, providing an efficient and environmentally benign strategy for synthesizing complex indole derivatives.
Mechanochromic Organic Micro‐Laser
Authors: Sun Chun‐Lin , Li Jun , Ye Juan , Chai Yun‐Fei , Ding Yun‐Tao , Ma Jian‐Rong , Wang Lin , Tian Yongjun , Zhang Hao‐Li 
Published: November 2024

AbstractThis work presents the first demonstration of a mechanochromic organic micro‐laser, which exhibits remarkable wide range pressure sensing characteristics. The gain material, pinacolato boronate ester functionalized anthanthrene (AnBPin), is designed by incorporating mechanofluorochromic (MFC) properties into organic laser dye. The AnBPin exhibits a reversible transition between green and orange fluorescence upon grinding annealing and recrystallization cycle, and its micro‐crystal exhibits typical organic micro‐laser behaviors. Applying localized mechanical pressure as low as 0.1 MPa inhibits micro‐laser behavior at the given spot. In contrast, under 1 to 2 GPa hydrostatic pressure, the organic laser maintains narrow emission while showing a pressure‐dependent shift in emission wavelength. By combining theory and experimentation, we attribute the unusual pressure‐correlated emission spectroscopy to the unique interleaved locked crystal structure. Understanding the mechanochromic laser behavior in AnBPin micro‐crystals under an unprecedented pressure range significantly expands the family of organic micro‐lasers and provides a new route for wide‐range photonic pressure detection.
Unsymmetric Protonation Driven Highly Efficient H2O2 Photosynthesis in Supramolecular Photocatalysts via One‐Step Two‐Electron Oxygen Reduction
Authors: Li Wenting , Han Bing , Liu Yuhan , Xu Jingyi , He Huarui , Wang Gege , Li Junshan , Zhai Yaxin , Zhu Xiaolin , Zhu Yongfa 
Published: November 2024

AbstractPhotocatalytic hydrogen peroxide (H2O2) production has emerged as an attractive alternative to the traditional anthraquinone process. However, its performance is often hindered by low selectivity and sluggish kinetics of oxygen reduction reaction (ORR). Herein, we report an anthrazoline‐based supramolecular photocatalyst, SA‐SADF‐H+, featuring an unsymmetric protonation structure for H2O2 photosynthesis from water and air. The introduction of unsymmetric protonation disrupts the initial mirror symmetry of SADF, significantly enhancing the molecular dipole and facilitating efficient charge separation and electron transfer. Additionally, this modification increases the hydrophilicity of SA‐SADF‐H+, enabling the interaction of water and dissolved oxygen with the catalytic sites. The altered electron density distribution creates numerous dual active sites for Yeager‐type O2 adsorption, facilitating an efficient ORR towards H2O2 via a direct one‐step two‐electron pathway. Notably, SA‐SADF‐H+ achieves an outstanding photocatalytic H2O2 production at a rate of 4666.7 μmol L−1 h−1, with a remarkable solar‐to‐chemical conversion (SCC) of 1.35 %, surpassing most organic photocatalytic systems. Furthermore, SA‐SADF‐H+ demonstrates remarkable photocatalytic antibacterial activity, achieving 100 % antibacterial efficiency against Staphylococcus aureus within 60 min.
Polyoxotungstate Featuring Zinc‐Ion‐Triggered Structural Transformation as An Efficient Electrolyte Additive for Aqueous Zinc‐Ion Batteries
Authors: Chen Yi , Zhang Ze‐Xun , Cai Ping‐Wei , Guo Zheng‐Wei , Lu Zhi‐Wen , Sun Cai , Li Xin‐Xiong , Chen Jun‐Xiang , Wen Zhen‐Hai , Zheng Shou‐Tian 
Published: November 2024

AbstractIt is promising but still challenging for the widespread application of aqueous zinc batteries due to the poor reversibility of the zinc anode caused by prevalent dendrite growth and pronounced interfacial side reactions. Herein, we report a rare soluble and water‐stable high‐nuclearity {Nd9Si4W39} polyoxotungstate. Interestingly, upon encountering Zn2+ ions, the discrete {Nd9Si4W39} nanocluster undergoes a structural transformation to form an infinitely extended cluster‐based {[Zn(H2O)4]3[Nd9Si4W39]2} two‐dimensional honeycomb layer, with which atomic‐level Zn2+ ion effects in reconstructing the layer are determined. More interestingly, we demonstrate that the structural transformation property renders the {Nd9Si4W39} cluster an efficient electrolyte additive for aqueous zinc batteries, enabling the formation of the 2D layer as a protective layer on the zinc anode, significantly enhancing the reversibility of the zinc anode. Compared to the pristine Zn//Zn symmetric battery, the Zn//Zn symmetric battery with the {Nd9Si4W39} additive exhibits an extended lifespan of over 2000 hours at a current density of 1 mA cm−2. In situ optical microscopy, Raman spectroscopy, and molecular dynamics simulations reveal that the formation of the protective layer effectively promotes uniform zinc deposition, and inhibits zinc agglomeration, dendrite growth, and side reactions, thereby enabling the zinc anode to exhibit high reversibility and long‐term service life.
Role of miRNAs in breast cancer development and progression: Current research
Authors: Kumar Sachin , Ranga Abhishek 
Published: November 2024

AbstractBreast cancer, a complex and heterogeneous ailment impacting numerous women worldwide, persists as a prominent cause of cancer‐related fatalities. MicroRNAs (miRNAs), small non‐coding RNAs, have garnered significant attention for their involvement in breast cancer's progression. These molecules post‐transcriptionally regulate gene expression, influencing crucial cellular processes including proliferation, differentiation, and apoptosis. This review provides an overview of the current research on the role of miRNAs in breast cancer. It discusses the role of miRNAs in breast cancer, including the different subtypes of breast cancer, their molecular characteristics, and the mechanisms by which miRNAs regulate gene expression in breast cancer cells. Additionally, the review highlights recent studies identifying specific miRNAs that are dysregulated in breast cancer and their potential use as diagnostic and prognostic biomarkers. Furthermore, the review explores the therapeutic potential of miRNAs in breast cancer treatment. Preclinical studies have shown the effectiveness of miRNA‐based therapies, such as antagomir and miRNA mimic therapies, in inhibiting tumor growth and metastasis. Emerging areas, including the application of artificial intelligence (AI) to advance miRNA research and the “One Health” approach that integrates human and animal cancer insights, are also discussed. However, challenges remain before these therapies can be fully translated into clinical practice. In conclusion, this review emphasizes the significance of miRNAs in breast cancer research and their potential as innovative diagnostic and therapeutic tools. A deeper understanding of miRNA dysregulation in breast cancer is essential for their successful application in clinical settings. With continued research, miRNA‐based approaches hold promise for improving patient outcomes in this devastating disease.
Engineering Gas‐Releasing Nanomaterials for Efficient Wound Healing
Authors: Duan Yutian , Li Lei , Hu Jinming , Zheng Bin , He Kewu 
Published: November 2024

AbstractThe escalating prevalence of tissue damage and its associated complications has elicited global apprehension. While nanomaterial‐based wound healing exhibits significant potential in terms of curbing infections and surpassing conventional methods, unresolved concerns regarding nanomaterial controllability and precision remain unresolved, jeopardizing its practical applications. In recent years, a unique strategy for creating gas‐releasing nanomaterials for wound repair has been proposed, involving the creation of gas‐releasing nanomaterials to facilitate wound repair by generating gas donor moieties. The operational spatiotemporal responsiveness and broad‐spectrum antibacterial properties of these gases, combined with their inability to generate bacterial resistance like traditional antibiotics, establish their efficacy in addressing chronic non‐healing wounds, specifically diabetic foot ulcers (DFUs). In this review, we delve into the intricacies of wound healing process, emphasizing the chemical design, functionality, bactericidal activity, and potential of gas‐release materials, encompassing NO, CO, H2S, O2, CO2, and H2, for effective wound healing. Furthermore, we explore the advancements in synergistic therapy utilizing these gases, aiming to enhance our overall comprehension of this field. The insights gleaned from this review will undoubtedly aid researchers and developers in the creation of promising gas‐releasing nanomaterials, thus propelling efficient wound healing in the future.
Unraveling the Mechanism of Stereospecific Self‐Promoted N‐Glycosylations
Authors: Videcrantz Faurschou Natasha , Sauer Stephan P. A. , Pedersen Christian Marcus 
Published: November 2024

AbstractIn this study, the mechanism of self‐promoted N‐glycosylations is extensively investigated through kinetic experiments, computational studies, and nucleophilic competition experiments. Based on the findings, the mechanism is proposed to be initiated by proton transfer from the acidic sulfonyl carbamate to the trichloroacetimidate, upon formation of an associated contact ion pair. This ion pair then collapses in an SN1‐like fashion, with formation of an oxocarbeniumion‐like intermediate. According to the proposed mechanism, stereospecificity arises from the associated nature of all intermediates formed throughout the reaction. During the mechanistic study, it was also found that the sulfonyl carbamates have catalytic properties if a competing nucleophile is present.
Chirality‐Dependent Anisotropic Nonlinear Optical Effect in Low‐Dimensional Hybrid Metal Halides
Authors: Okada Daichi 
Published: November 2024

AbstractLow‐dimensional hybrid metal halides (LDHMHs) have emerged as a highly promising class of functional materials for a wide range of optoelectronic applications. Their exceptional structural tunability, facilitated by the hybridization of metal halides with organic compounds, enables the formation of three‐, two‐, one‐, or zero‐dimensional structures. This flexibility in structural design also allows the incorporation of chirality into the crystalline lattice, giving rise to novel LDHMH materials that are capable of selectively interacting with the spin angular momentum of electrons and photons. Among the unique optoelectronic properties of LDHMHs, the focus of this concept article is their chiroptical nonlinear optical (NLO) effect. LDHMHs demonstrate a highly effective discrimination and generation of circularly polarized (CP) light in the NLO regime, particularly in the second harmonic generation (SHG) process, referred to as SHG‐circular dichroism (SHG‐CD) and CP‐SHG. These anisotropic responses are several orders of magnitude larger than linear chiroptical responses, such as CD and CP luminescence; consequently, LDHMHs are expected to be promising candidates for future optical‐information devices and encryption systems. This article introduces recently reported chiral LDHMH materials that exhibit excellent CP‐dependent anisotropic SHG responses.
Actin Polymerization Status Regulates Tenocyte Homeostasis Through Myocardin‐Related Transcription Factor‐A
Authors: West Valerie C. , Owen Kaelyn E. , Inguito Kameron L. , Ebron Karl Matthew M. , Reiner Tori N. , Mirack Chloe E. , Le Christian H. , de Cassia Marqueti Rita , Snipes Steven , Mousavizadeh Rouhollah , King Rylee E. , Elliott Dawn M. , Parreno Justin 
Published: November 2024

ABSTRACTThe actin cytoskeleton is a potent regulator of tenocyte homeostasis. However, the mechanisms by which actin regulates tendon homeostasis are not entirely known. This study examined the regulation of tenocyte molecule expression by actin polymerization via the globular (G‐) actin‐binding transcription factor, myocardin‐related transcription factor‐a (MRTF). We determined that decreasing the proportion of G‐actin in tenocytes by treatment with TGFβ1 increases nuclear MRTF. These alterations in actin polymerization and MRTF localization coincided with favorable alterations to tenocyte gene expression. In contrast, latrunculin A increases the proportion of G‐actin in tenocytes and reduces nuclear MRTF, causing cells to acquire a tendinosis‐like phenotype. To parse out the effects of F‐actin depolymerization from regulation by MRTF, we treated tenocytes with cytochalasin D. Exposure of cells to cytochalasin D increases the proportion of G‐actin in tenocytes. However, as compared to latrunculin A, cytochalasin D has a differential effect on MRTF localization by increasing nuclear MRTF. This led to an opposing effect on the regulation of a subset of genes. The differential regulation of genes by latrunculin A and cytochalasin D suggests that actin signals through MRTF to regulate a specific subset of genes. By targeting the deactivation of MRTF through the inhibitor CCG1423, we verify that MRTF regulates Type I Collagen, Tenascin C, Scleraxis, and α‐smooth muscle actin in tenocytes. Actin polymerization status is a potent regulator of tenocyte homeostasis through the modulation of several downstream pathways, including MRTF. Understanding the regulation of tenocyte homeostasis by actin may lead to new therapeutic interventions against tendinopathies, such as tendinosis.
Lower estimated glomerular filtration rate relates to cognitive impairment and brain alterations
Authors: Rahayel Shady , Goupil Rémi , Genest Dominique Suzanne , Lamarche Florence , Agharazii Mohsen , Ayral Violette , Tremblay Christina , Madore François 
Published: November 2024

AbstractINTRODUCTIONChronic kidney disease (CKD) is associated with cognitive decline and changes in brain structure. However, their associations remain unclear, particularly the selective vulnerability characteristics that make some brain regions more vulnerable.METHODSWe investigated the baseline association between estimated glomerular filtration rates (eGFR) and cognitive function in 15,897 individuals from the CARTaGENE cohort. We performed vertex‐based magnetic resonance imaging (MRI) analyses between eGFR and longitudinal cortical thickness in the 1397 participants who underwent brain MRI after 6 years. Imaging transcriptomics was used to characterize the gene expression and neurodegenerative features associated with this association.RESULTSLower eGFR correlated with reduced cognitive performance and brain structure. Brain regions associated with eGFR were enriched for mitochondrial and inflammatory‐related genes. These associations occurred independently from age, sex, education, and body mass index (BMI), Framingham risk score, and white matter lesion volume.DISCUSSIONThis study highlights the link between reduced eGFR, cognitive impairment, and brain structure, revealing some of the kidney–brain axis mechanisms.Highlights
Lower eGFR is associated with reduced cognitive abilities.
Structural brain changes are mediated by eGFR levels.
Specific gene expression patterns correlate with lower eGFR and brain changes.
Mitochondrial and inflammation‐related genes were enriched in these patterns.
Smithian–Spathian carbonate geochemistry in the northern Thaynes Group influenced by multiple styles of diagenesis
Authors: Todes Jordan P. , Blattmann Franziska R. , Vennemann Torsten , Schneebeli‐Hermann Elke , Bucher Hugo , Razionale Dan P. , Blättler Clara L. 
Published: November 2024

AbstractThe Smithian–Spathian boundary interval is characterised by a positive carbon isotopic excursion in both δ13Ccarb and δ13Corg, concurrent with a major marine ecosystem reorganisation and the resurgence of microbialite facies. While these δ13C records have been traditionally interpreted as capturing global carbon cycle behaviour, recent studies have suggested that at least some excursions in early Triassic δ13C values may incorporate influences from authigenic or early diagenetic processes. To examine the mechanistic drivers of Smithian–Spathian boundary geochemistry, the carbonate geochemistry of a core from Georgetown, Idaho (USA), was analysed using a coupled δ44/40Ca, δ26Mg and trace‐metal framework. While the δ13C record in the Georgetown core is broadly similar to other Smithian–Spathian boundary sections, portions of the record coincide with substantial shifts in δ44/40Ca, δ26Mg and trace‐metal compositions that cannot feasibly be interpreted as primary. Furthermore, these geochemical variations correspond with lithology: The δ13C record is modulated by variations in the extent of dolomitisation, and the diagenetic styles recognised here coincide with individual lithostratigraphic units. A primary shift in local sea water δ13C values is inferred from the most geochemically unaltered strata, from ca 3‰ in the middle Smithian to ca 5‰ in the early Spathian, although the timing and pathway through which this occurs cannot be readily identified nor extrapolated globally. Therefore, the Georgetown core may not directly record exogenic carbon cycle evolution, showing that there is a need for the careful reconsideration of the Smithian–Spathian boundary—and more broadly, Early Triassic—geochemical records to examine potential local and diagenetic influences on sedimentary geochemistry.