bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building the holy brand: Towards a theoretical model of brand religiosity
Authors: Wang Cheng Lu , Sarkar Abhigyan , Sarkar Juhi Gahlot 
Published: February 2018

AbstractThis article introduces the brand religiosity construct and delineates its relationship with antecedents and consequences from a dynamic stage‐wise progression perspective. The proposed theoretical framework demonstrates the process that brand religiosity is formed through a series of steps, from brand appreciation, romantic brand love and brand devotion to brand religiosity. The proposed model specifies that the link between brand appreciation and romantic brand love is moderated by individual difference variables including consumer materialism and emotional attachment styles. Meanwhile, the relationship between romantic brand love and brand devotion is further proposed to be enhanced by the sense of brand community but weakened by individual's religiosity. Finally, the influence of brand religiosity on consumer behaviour and brand consumption, such as transcendental experience and proactive sustaining ritualistic behaviour is discussed.
Infiltrative lamina propria invasion pattern as an independent predictor for cancer‐specific and overall survival of instillation treatment‐naïve stage T1 high‐grade urothelial bladder cancer
Authors: Otto Wolfgang , van Rhijn Bas WG , Breyer Johannes , Bertz Simone , Eckstein Markus , Mayr Roman , Lausenmeyer Eva M , Denzinger Stefan , Burger Maximilian , Hartmann Arndt 
Published: February 2018

ObjectivesTo investigate established prognostic factors and relatively new histopathological tumor characteristics including metric substage and lamina propria invasion patterns in a large series of T1 high‐grade non‐muscle‐invasive bladder cancer.MethodsBetween 1989 and 2012, 322 patients with initial stage T1 high‐grade bladder cancer underwent transurethral resection, followed by re‐transurethral resection and a conservative approach with follow‐up regime alone or instillation treatment. Transurethral resection specimens were reassessed by two experienced urological pathologists for tumor grade according to the World Health Organization 1973 classification, metric T1 substage, lamina propria invasion pattern and associated carcinoma in situ. The median follow‐up period was 42 months (interquartile range 25–72 months). In addition to Kaplan–Meier analyses, uni‐ and multivariable Cox regression analyses were used to compare progression‐free survival, cancer‐specific survival and overall survival for the studied parameters comparing two subcohorts.ResultsWhile in patients after instillation treatment no examined feature was shown as an independent predictor for prognosis, there were predictive histopathological features in multivariable Cox regression analyses in instillation treatment‐naïve patients: associated carcinoma in situ (hazard ratio 2.278, 95% confidence interval 1.119–4.634, P = 0.023) and World Health Organization 1973 grade 3 (hazard ratio 2.950, 95% confidence interval 1.021–8.536, P = 0.046) for worse progression‐free survival, infiltrative lamina propria tumor pattern for worse cancer‐specific survival (hazard ratio 2.369, 95% confidence interval 1.034–5.429, P = 0.042) and overall survival (hazard ratio 1.049, 95% confidence interval 1.024–1.075, P = 0.001).ConclusionsThe results of the present T1 high‐grade bladder cancer series suggest that lamina propria invasion pattern is a promising parameter to predict the prognosis of T1 high‐grade bladder cancer in an instillation treatment‐naïve subcohort. Prospective multicenter evaluations are warranted. The need for instillation treatment in T1 high‐grade bladder cancer is clearly demanded.
New Light on the Remittances‐Poverty‐Health Nexus in Macedonia
Authors: Petreski Blagica , Tumanoska Despina , Dávalos Jorge , Petreski Marjan 
Published: February 2018

AbstractMacedonia receives about 10 per cent of GDP as cash remittances per year while a third of the population faces poverty. The study aims to investigate whether remittances improve the poverty and health of individual remittance‐receivers in Macedonia. To that end, we rely on the 2008 Remittances’ Survey and a sequential structural model linking remittances to social indicators. We find that remittances have a significant effect oto consumption, in particular health consumption, hence contribute to reducing poverty. In turn, improved health consumption significantly reduces the incidence of bad health among receivers. This finding lends support to the claim that remittances serve an informal social protection in Macedonia.
Graphical Instructions for Administration and Scoring the Mini‐Cog: Results of a Randomized Clinical Trial
Authors: Tam Edlira , Gandesbery Benjamin T. , Young Laura , Borson Soo , Gorodeski Eiran Z. 
Published: February 2018

ObjectivesTo develop a novel set of graphical Mini‐Cog instructions designed to aid clinicians previously untrained on the Mini‐Cog in accurate administration and scoring and to determine whether use of these graphical instructions improved the speed and accuracy of deployment of this tool.DesignRandomized clinical trial.SettingTesting was conducted in a simulated environment with a mock patient.ParticipantsRegistered nurses working in inpatient or outpatient settings at a large academic medical center who had no prior exposure to or training with the Mini‐Cog (N=92).MeasurementsOur primary outcome was the composite proportion of nurses who made errors in administration or scoring of the Mini‐Cog.ResultsNone of the nurses in the graphical instruction group and 28 (61%) in the standardized instructions group (15 (33%) made administration errors, 22 (48%) made scoring errors) made errors. Nurses randomly assigned to the graphical group were able to read (median 36 vs 54 seconds, P<.001), administer (46 vs 62 seconds, P<.001), and score (15 vs 84 seconds, P<.001) the Mini‐Cog more quickly than those in the standardized instructions group.ConclusionGraphical instructions increase the accuracy and speed of test administration in nurses without prior training in Mini‐Cog administration. Further research is necessary to confirm these findings and evaluate the use of this method in other healthcare professionals and settings.
Dietary outcomes of overweight fathers and their children in the Healthy Dads, Healthy Kids community randomised controlled trial
Authors: Williams A. , de Vlieger N. , Young M. , Jensen M. E. , Burrows T. L. , Morgan P. J. , Collins C. E. 
Published: February 2018

AbstractBackgroundFew studies have examined dietary intake changes following a weight loss intervention in fathers and the association between father–child dietary intakes. The present study aimed to: (i) evaluate the change in dietary intake in overweight fathers randomised to a family‐based lifestyle intervention [Healthy Dads Healthy Kids (HDHK)] versus controls and (ii) investigate whether an association exists between father–child dietary intakes.MethodsA secondary analysis was conducted of father–child baseline and 3‐month post‐intervention data (n = 93) collected in the HDHK community randomised controlled trial. Intention‐to‐treat linear mixed models were used to assess dietary changes by group, time (baseline and 3‐month) and the group‐by‐time interaction. Cohens d was used to determine effect sizes.ResultsSignificant group‐by‐time effects (all P < 0.05) favouring fathers in the intervention group were identified for total daily energy intake (−1956 kJ, d = 0.74), total sugars (−45 g, d = 0.63), sodium (−414 mg, d = 0.58) and % energy from nutrient‐dense, core foods (+10.1%, d = 0.86), fruit (+2.4%, d = 0.71), vegetarian protein sources (+1.2%, d = 0.57), pre‐packed snacks (+1.7%, d = 0.58) and sugar‐sweetened beverages (−4.1%, d = 0.58). At baseline, positive correlations were observed between father–child intakes for a number of dietary variables, and significant correlations were observed between father–child change scores for % energy carbohydrate (r = 0.35, P = 0.023), % energy from fruit (r = 0.47, P = 0.002), vegetarian protein sources (r = 0.46, P = 0.002) and frequency of consuming meals with vegetables (r = 0.38, P = 0.012).ConclusionsThe HDHK intervention successfully improved some aspects of father's dietary intakes compared to controls. The fathers’ eating patterns also correlated with those of their children for several dietary variables. These novel data suggest that fathers can be targeted as agents of dietary change within obesity prevention and treatment programmes.
Animal models of Wilson disease
Authors: Reed Emily , Lutsenko Svetlana , Bandmann Oliver 
Published: February 2018

AbstractWilson disease (WD) is an autosomal recessive disorder of copper metabolism manifesting with hepatic, neurological and psychiatric symptoms. The limitations of the currently available therapy for WD (particularly in the management of neuropsychiatric disease), together with our limited understanding of key aspects of this illness (e.g. neurological vs. hepatic presentation) justify the ongoing need to study WD in suitable animal models. Four animal models of WD have been established: the Long‐Evans Cinnamon rat, the toxic‐milk mouse, the Atp7b knockout mouse and the Labrador retriever. The existing models of WD all show good similarity to human hepatic WD and have been helpful in developing an improved understanding of the human disease. As mammals, the mouse, rat and canine models also benefit from high homology to the human genome. However, important differences exist between these mammalian models and human disease, particularly the absence of a convincing neurological phenotype. This review will first provide an overview of our current knowledge of the orthologous genes encoding ATP7B and the closely related ATP7A protein in C. elegans, Drosophila and zebrafish (Danio rerio) and then summarise key characteristics of rodent and larger mammalian models of ATP7B‐deficiency.
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Obstructive Sleep Apnea and Neurocognitive Dysfunction in Edentulous Patients
Authors: Bagchi Soumyojeet , Tripathi Arvind , Tripathi Suryakant , Kar Sushil , Tiwari Sarvada Chandra , Singh Juhi 
Published: February 2018

AbstractPurposeTo record the incidence of cognitive dysfunction in edentulous patients suffering from obstructive sleep apnea (OSA) and establish a plausible hypothesis to explain the correlation of cognitive dysfunction and OSA.Materials and MethodsIn this study, 315 edentulous patients (aged 60 to 65 years) visiting the outpatient department at Saraswati Dental College, Lucknow were recruited from January 2013 to October 2015. Prosthodontic Diagnostic Index (PDI) classification was used to assess the intraoral condition to relate it with the span of edentulousness. The BERLIN questionnaire and Epworth Sleepiness Scales were used to diagnose sleep‐disordered breathing, following which the patients were put through all‐night polysomnography. The apnea‐hypopnea index (AHI) scores were derived. Mild and moderate OSA patients were classified into mild, moderate, and severe cognitive dysfunction based on SGRQ‐C and SCD. Data were tabulated according to a new classification (Cognitive Dysfunction of Dental Sleep Medicine Patients [CDDSMP] Classification) designed specifically for this study. Data were analyzed using SPSS v15.0. Scores were tabulated as mean ± SD and median [IQR] values. Change from baseline was analyzed using Wilcoxon signed rank test.ResultsMean scores at different time intervals were 3.03 ± 1.76 (3 months), 2.98 ± 1.80 (6 months), and 2.81 ± 1.84 (9 months). The median [IQR] values of scores at all time intervals except 9 months were 3 [1 to 5]. At 9 months, median [IQR] was 2 [1 to 5]. A significant change in scores was observed in the 3‐month interval (p ≤ 0.001).ConclusionsThe severity of OSA and neurocognitive dysfunction could be directly related to the PDI classification and the span of edentulousness of the patient and modified mandibular advancement device treatment significantly improved the patients’ condition, which was reflective from 3 months post‐intervention itself.
Does obestatin modulate the hypothalamic appetite‐regulating network in peripubertal sheep?
Authors: Szlis M. , Polkowska J. , Skrzeczyńska E. , Przybył B. J. , Wójcik‐Gładysz A. 
Published: February 2018

SummaryThe participation of peripheral peptides in the processes regulating the food intake (energy homeostasis) at the central nervous system level remains unclear. This study focuses on the role of obestatin in neuronal activity within the hypothalamic appetite‐regulating network in ruminants. The animals (n = 28) were randomly divided into two groups. The sheep in the control group received intracerebroventricular infusions of the Ringer‐Locke solution, and the sheep in obestatin group were infused with obestatin (diluted in the Ringer‐Locke solution) at 25 μg per 120 μl/hr. The series of four 1‐hr infusions on 3 consecutive days were performed, and immediately after the experiment, the sheep were decapitated. Selected brain regions were fixed in situ for further immunohistochemical analysis, while the remaining ones were frozen for real‐timeRT‐qPCRanalysis. Obestatin infusion elicited changes in the neuropeptide Y (NPY) neuronal network in the hypothalamus. The results obtained show that exogenous obestatin evoked an increase innpyandagrpmRNAexpression in the mediobasal hypothalamus (MBH), while the immunoreactivity forNPYwas decreased in the arcuate and periventricular nuclei. The increase incartandpomcmRNAexpression in theMBHwas also observed. Moreover, increased levels ofgpr39receptor andnpyreceptor 1mRNAexpression were evident in obestatin‐infused sheep. Based on these results, it can be concluded that obestatin plays a role in the modulation of appetite‐regulating network at the central level in sheep. The results obtained suggest that the underlying mechanism may involve the modification of the activity ofNPY/AgRPandCART/α‐MSHneurons in the arcuate nucleus.
Atypical behavioural, metabolic and thermoregulatory responses to hypoxia in the naked mole rat (Heterocephalus glaber)
Authors: Kirby Alexia M , Fairman Garrett D , Pamenter Matthew E 
Published: February 2018

AbstractHypoxia compromises aerobic energy production at the cellular level, but hypoxic environments are commonly encountered by mammals. In response, mammals typically exhibit compensatory physiological and behavioural adaptations that help to restore energetic homeostasis by reducing physical activity and body temperature (Tb) to lower metabolic demand. Naked mole rats (NMRs; Heterocephalus glaber) are among the most hypoxia‐tolerant mammals identified but their behavioural and thermal responses to acute hypoxia are poorly characterized. Using behavioural tracking software, we examined the effects of acute hypoxia (1 h at 7% O2) on physical activity and Tb in animals held at their natural burrow temperature (30°C), or at temperatures above (38°C) or below (20°C). In separate experiments, we used respirometry to measure metabolic rate under the same conditions. Physical activity decreased ~26–60% and Tb decreased by ~ 1.9–3.7°C during hypoxia in all temperatures. Normoxic metabolic rate was highest at 20°C, but was suppressed to similar rates in hypoxia across all temperatures. When animals were given the opportunity to escape their burrow temperature to either warmer or colder chambers during the hypoxic episode, NMRs surprisingly avoided the cold chamber, suggesting they are unable to take advantage of anapyrexia. Conversely, NMRs were able to use behavioural thermoregulation to maintain Tb in hypoxia when given the choice of temperatures within and above their burrow temperature. Taken together, these findings indicate that NMRs respond to acute hypoxia with reversible decreases in physical activity, Tb and metabolic rate across a range of ambient temperatures to reduce oxygen requirements.
Metacognitive Instruction Enhances the Effectiveness of Corrective Feedback: Variable Effects of Feedback Types and Linguistic Targets
Authors: Sato Masatoshi , Loewen Shawn 
Published: February 2018

AbstractThis study explored the impact of metacognitive instruction provided in conjunction with corrective feedback, investigating the moderating effects of two types of implicit corrective feedback (input‐providing conversational recasts vs. output‐prompting clarification requests) that targeted English third‐person singular –s and possessive determiners his/her. Adult English as a foreign language learners from intact classes (N = 83) were assigned to four conditions: metacognitive instruction plus input‐providing recasts, input‐providing recasts only, metacognitive instruction plus output‐prompting clarification requests, and output‐prompting clarification requests only. Metacognitive instruction enhanced the effect of conversational recasts that otherwise had minimal impact but had no added benefit for clarification requests that supported language development without metacognitive instruction. Although the effect of metacognitive instruction was not moderated by linguistic structure, effectiveness of corrective feedback depended on linguistic target. Although corrective feedback in general impacted third‐person singular –s more, the comparison of feedback types showed that the advantageous effect of clarification requests was found only for possessive determiners, the more salient and communicatively valuable structure.Open PracticesThis article has been awarded an Open Materials badge. All materials are publicly accessible via the IRIS Repository at https://www.iris-database.org. Learn more about the Open Practices badges from the Center for Open Science: https://osf.io/tvyxz/wiki.
Feeling of incomplete emptying with little post‐void residual in patients with lower urinary tract symptoms: Clinical implications and treatment outcomes
Authors: Kobayashi Minoru , Tokura Yuumi , Kambara Tsunehito , Nukui Akinori , Kamai Takao 
Published: February 2018

ObjectiveThe aim of the present study was to examine the clinical features and implications of a feeling of incomplete emptying despite little post‐void residual (PVR), because it remains unclear why patients are bothered by such an undefined feeling.MethodsData were collected prospectively from 173 consecutive patients (135 men, 38 women) with a complaint of a feeling of incomplete emptying with PVR <50 mL at an initial visit. The International Prostate Symptom Score (IPSS), quality of life (QoL) score, overactive bladder symptom score (OABSS), prostate volume, and PVR were determined. Subjective symptoms were re‐evaluated after 8 weeks of medication for co‐occurring urinary symptoms.ResultsMost patients presented with high scores for a feeling of incomplete emptying, determined by Item 1 on the IPSS. The score for a feeling of incomplete emptying was positively correlated with all IPSS‐related scores. Men with a feeling of incomplete emptying more often had co‐occurring voiding symptoms with higher scores than women. Significant symptom relief was achieved for a feeling of incomplete emptying as well as voiding and storage symptoms after treatment. In men, there was a positive correlation between the extent of symptom relief of a feeling of incomplete emptying and voiding symptoms.ConclusionsA feeling of incomplete emptying with little PVR is frequently observed in routine clinical practice in both men and women, along with voiding and storage symptoms. This feeling was simultaneously improved by medications for co‐occurring urinary symptoms.
Efficacy of mirabegron for overactive bladder with human T cell lymphotropic virus‐1 associated myelopathy
Authors: Matsuo Tomohiro , Miyata Yasuyoshi , Nakamura Tatsufumi , Satoh Katsuya , Sakai Hideki 
Published: February 2018

ObjectiveMirabegron is widely considered as an effective and safe drug for patients with overactive bladder (OAB). However, there is no evidence regarding the efficacy of mirabegron in human T cell lymphotropic virus‐1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients with OAB symptoms. The aim of the present study was to clarify the efficacy of mirabegron in HAM/TSP patients with OAB symptoms.MethodsThe present study evaluated the efficacy of mirabegron treatment (50 mg, once daily) in nineteen HAM/TSP patients with OAB symptoms by assessing subjective symptoms using the overactive bladder symptom score (OABSS) and International Prostate Symptom Score (IPSS) before and 12 weeks after administration. Voided volume (VV), maximum flow rate (Qmax), and post‐void residual (PVR) urine volume were evaluated as objective symptoms.ResultsMirabegron treatment improved OABSS in terms of night‐time frequency, urgency, and total score (P < .001). In addition, on the IPSS, mirabegron therapy improved urgency, nocturia, storage symptoms (Questions 2, 4 and 7 on the IPSS), as well as the total score (P < .001). The quality of life (QoL) on the IPSS also improved after treatment (P < .001). However, there were no significant changes in objective symptoms, as measured by VV, Qmax, and PVR, after treatment. One patient (5.3%) complained of dry mouth; because this adverse effect was very mild, the patient did not discontinue mirabegron.ConclusionsMirabegron administration improved subjective symptoms in HAM/TSP patients with neurogenic OAB.
The genomic footprint of climate adaptation in Chironomus riparius
Authors: Waldvogel Ann‐Marie , Wieser Andreas , Schell Tilman , Patel Simit , Schmidt Hanno , Hankeln Thomas , Feldmeyer Barbara , Pfenninger Markus 
Published: February 2018

AbstractThe gradual heterogeneity of climatic factors poses varying selection pressures across geographic distances that leave signatures of clinal variation in the genome. Separating signatures of clinal adaptation from signatures of other evolutionary forces, such as demographic processes, genetic drift and adaptation, to nonclinal conditions of the immediate local environment is a major challenge. Here, we examine climate adaptation in five natural populations of the harlequin fly Chironomus riparius sampled along a climatic gradient across Europe. Our study integrates experimental data, individual genome resequencing, Pool‐Seq data and population genetic modelling. Common‐garden experiments revealed significantly different population growth rates at test temperatures corresponding to the population origin along the climate gradient, suggesting thermal adaptation on the phenotypic level. Based on a population genomic analysis, we derived empirical estimates of historical demography and migration. We used an FST outlier approach to infer positive selection across the climate gradient, in combination with an environmental association analysis. In total, we identified 162 candidate genes as genomic basis of climate adaptation. Enriched functions among these candidate genes involved the apoptotic process and molecular response to heat, as well as functions identified in studies of climate adaptation in other insects. Our results show that local climate conditions impose strong selection pressures and lead to genomic adaptation despite strong gene flow. Moreover, these results imply that selection to different climatic conditions seems to converge on a functional level, at least between different insect species.