bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postsynaptic p47phox regulates long-term depression in the hippocampus
Authors: Yi Jee Hyun , Kim Dong Hyun , Piers Thomas M. , Kim Seung Chan , Whitcomb Daniel J. , Regan Philip , Cho Kwangwook 
Published: July 2018

AbstractIt is well documented that reactive oxygen species (ROS) affects neurodegeneration in the brain. Several studies also implicate ROS in the regulation of synapse function and learning and memory processes, although the precise source of ROS generation within these contexts remains to be further explored. Here we show that postsynaptic superoxide generation through PKCζ-activated NADPH oxidase 2 (NOX2) is critical for long-term depression (LTD) of synaptic transmission in the CA1–Shaffer collateral synapse of the rat hippocampus. Specifically, PKCζ-dependent phosphorylation of p47phox at serine 316, a NOX2 regulatory subunit, is required for LTD but is not necessary for long-term potentiation (LTP). Our data suggest that postsynaptic p47phox phosphorylation at serine 316 is a key upstream determinant for LTD and synapse weakening.
Environmental engineering for quantum energy transport
Authors: Uchiyama Chikako , Munro William J. , Nemoto Kae 
Published: July 2018

AbstractTransport phenomena are ubiquitous throughout the science, engineering, and technology disciplines as it concerns energy, mass, charge, and information exchange between systems. In particular, energy transport in the nanoscale regime has attracted significant attention within the physical science community due to its potential to explain complex phenomena like the electronic energy transfer in molecular crystals or the Fenna-Matthews-Olson (FMO)/light harvesting complexes in photosynthetic bacteria with long time coherences. Energy transport in these systems is highly affected by environmental noise but surprisingly not always in a detrimental way. It was recently found that situations exist where noise actually enhances the transport phenomena. Such noise can take many forms, but can be characterised in three basic behaviors: quantum, correlation in time, or space. All have been shown potential to offer an energy transport enhancement. The focus of this work is on quantum transport caused by stochastic environment with spatio-temporal correlation. We consider a multi-site nearest neighbor interaction model with pure dephasing environmental noise with spatio-temporal correlation and show how an accelerated rate for the energy transfer results especially under negative spatial correlation (anti-correlation). Spatial anti-correlation provides another control parameter to help one establish the most efficient transfer of energy and may provide new insights into the working of exciton transport in photosynthetic complexes. Further the usage of spatio-temporal correlated noise may be a beneficial resource for efficient transport in large scale quantum networks.
Redefining environmental exposure for disease etiology
Authors: Rappaport Stephen M. 
Published: July 2018

AbstractEtiological studies of human exposures to environmental factors typically rely on low-throughput methods that target only a few hundred chemicals or mixtures. In this Perspectives article, I outline how environmental exposure can be defined by the blood exposome—the totality of chemicals circulating in blood. The blood exposome consists of chemicals derived from both endogenous and exogenous sources. Endogenous chemicals are represented by the human proteome and metabolome, which establish homeostatic networks of functional molecules. Exogenous chemicals arise from diet, vitamins, drugs, pathogens, microbiota, pollution, and lifestyle factors, and can be measured in blood as subsets of the proteome, metabolome, metals, macromolecular adducts, and foreign DNA and RNA. To conduct ‘exposome-wide association studies’, blood samples should be obtained prospectively from subjects—preferably at critical stages of life—and then analyzed in incident disease cases and matched controls to find discriminating exposures. Results from recent metabolomic investigations of archived blood illustrate our ability to discover potentially causal exposures with current technologies.
Assessment of care pattern and outcome in hemangioblastoma
Authors: Huang Yuqian , Chan Lilian , Bai Harrison X. , Li Xuejun , Zhang Zishu , Wang Yinyan , Cao Ya , Karakousis Giorgos , Huang Raymond , Xiao Bo , Zhang Paul J. , Yang Li 
Published: July 2018

AbstractDue to its rarity, current literature assessing prognostic factors and survival outcomes of hemangioblastoma is limited. Patients with histologically confirmed hemangioblastoma were identified from the US National Cancer Data Base. 1488 patients met inclusion criteria. 644 patients underwent gross total resection (GTR), 220 subtotal resection (STR)/biopsy, 60 stereotactic radiosurgery (SRS), 15 external beam radiotherapy (EBRT), 51 surgery followed by radiotherapy (SR + RT) and 498 no treatment. Independent predictors of shorter OS included age ≥ 40 (HR, 3.897; 95% CI, 2.341–6.487; p < 0.001), Charlson-Deyo score ≥ 1(HR, 1.756; 95% CI, 1.213–2.544; p = 0.003), tumor location in the brainstem (HR, 1.955; 95% CI, 1.129–3. 384; p = 0.017) compared to cerebellum, no treatment (HR, 2530; 95% CI, 1.533–4.177; p < 0.001) and receipt of EBRT (HR, 2.860; 95% CI, 1.073–7.618; p = 0.036) compared to STR/biopsy. GTR was associated with longer OS (HR 0.617; 95% CI, 0.391–0.974; p = 0.038), while SRS had comparable OS to STR/biopsy. The overall trend of OS by treatment modality was consistent after matching to age- and sex-matched US population data. In patients younger than 40 years, treatment was not a significant predictor of OS. In conclusion, GTR remained the optimal treatment for hemangioblastoma. SRS may perform similarly to surgery alone. Treatment was not a significant predictor of survival in younger patients.
Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis
Authors: Klein Kerstin , Kato Masaru , Frank-Bertoncelj Mojca , Kolling Christoph , Ciurea Adrian , Gay Steffen , Ospelt Caroline 
Published: July 2018

AbstractTargeting epigenetic reader proteins by small molecule inhibitors represents a new therapeutic concept in autoimmune diseases such as rheumatoid arthritis (RA). Although inhibitors targeting bromodomain protein 1 (BRD1) are in development, the function of BRD1 has hardly been studied. We investigated the therapeutic potential of BRD1 inhibition in joint-resident cells in RA, synovial fibroblasts (SF) and macrophages. The proliferation of SF was decreased upon BRD1 silencing, accompanied by the downregulation of genes involved in cell cycle regulation. Silencing of BRD1 in SF decreased the basal expression of MMP1 but increased TNF-α- and LPS-induced levels of MMP3, IL6 and IL8. In monocyte-derived macrophages (MDM), silencing of BRD1 decreased the LPS-induced expression of TNF-α, but did not significantly affect basal and the TNF-α- and LPS-induced expression of IL6 and IL8. Our data point to a cell type- and a stimulus-specific function of BRD1. Inhibiting BRD1 could have potential beneficial effects in RA via decreasing the proliferation of SF. Anti-inflammatory effects were limited and only observed in MDM.
High-Performance Photodiode-Type Photodetectors Based on Polycrystalline Formamidinium Lead Iodide Perovskite Thin Films
Authors: Zhang Meng , Zhang Fan , Wang Yue , Zhu Lijie , Hu Yufeng , Lou Zhidong , Hou Yanbing , Teng Feng 
Published: July 2018

AbstractPhotodetectors based on three dimensional organic–inorganic lead halide perovskites have recently received significant attention. As a new type of light-harvesting materials, formamidinium lead iodide (FAPbI3) is known to possess excellent optoelectronic properties even exceeding those of methylammonium lead iodide (MAPbI3). To date, only a few photoconductor-type photodetectors based on FAPbI3 single crystals and polycrystalline thin films in a lateral structure have been reported. Here, we demonstrate low-voltage, high-overall-performance photodiode-type photodetectors in a sandwiched geometry based on polycrystalline α-FAPbI3 thin films synthesized by a one-step solution processing method and post-annealing treatment. The photodetectors exhibit a broadband response from the near-ultraviolet to the near-infrared (330–800 nm), achieving a high on/off current ratio of 8.6 × 104 and fast response times of 7.2/19.5 μs. The devices yield a photoresponsivity of 0.95 AW−1 and a high specific detectivity of 2.8 × 1012 Jones with an external quantum efficiency (EQE) approaching 182% at −1.0 V under 650 nm illumination. The photodiode-type photodetectors based on polycrystalline α-FAPbI3 thin films with superior performance consequently show great promise for future optoelectronic device applications.
Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression
Authors: Takada T. , Yamamoto T. , Matsuo H. , Tan J. K. , Ooyama K. , Sakiyama M. , Miyata H. , Yamanashi Y. , Toyoda Y. , Higashino T. , Nakayama A. , Nakashima A. , Shinomiya N. , Ichida K. , Ooyama H. , Fujimori S. , Suzuki H. 
Published: July 2018

AbstractChronic kidney disease (CKD) patients accumulate uremic toxins in the body, potentially require dialysis, and can eventually develop cardiovascular disease. CKD incidence has increased worldwide, and preventing CKD progression is one of the most important goals in clinical treatment. In this study, we conducted a series of in vitro and in vivo experiments and employed a metabolomics approach to investigate CKD. Our results demonstrated that ATP-binding cassette transporter subfamily G member 2 (ABCG2) is a major transporter of the uremic toxin indoxyl sulfate. ABCG2 regulates the pathophysiological excretion of indoxyl sulfate and strongly affects CKD survival rates. Our study is the first to report ABCG2 as a physiological exporter of indoxyl sulfate and identify ABCG2 as a crucial factor influencing CKD progression, consistent with the observed association between ABCG2 function and age of dialysis onset in humans. The above findings provided valuable knowledge on the complex regulatory mechanisms that regulate the transport of uremic toxins in our body and serve as a basis for preventive and individualized treatment of CKD.
The effect of succinate on brain NADH/NAD+ redox state and high energy phosphate metabolism in acute traumatic brain injury
Authors: Stovell Matthew G. , Mada Marius O. , Helmy Adel , Carpenter T. Adrian , Thelin Eric P. , Yan Jiun-Lin , Guilfoyle Mathew R. , Jalloh Ibrahim , Howe Duncan J. , Grice Peter , Mason Andrew , Giorgi-Coll Susan , Gallagher Clare N. , Murphy Michael P. , Menon David K. , Hutchinson Peter J. , Carpenter Keri L. H. 
Published: July 2018

AbstractA key pathophysiological process and therapeutic target in the critical early post-injury period of traumatic brain injury (TBI) is cell mitochondrial dysfunction; characterised by elevation of brain lactate/pyruvate (L/P) ratio in the absence of hypoxia. We previously showed that succinate can improve brain extracellular chemistry in acute TBI, but it was not clear if this translates to a change in downstream energy metabolism. We studied the effect of microdialysis-delivered succinate on brain energy state (phosphocreatine/ATP ratio (PCr/ATP)) with 31P MRS at 3T, and tissue NADH/NAD+ redox state using microdialysis (L/P ratio) in eight patients with acute major TBI (mean 7 days). Succinate perfusion was associated with increased extracellular pyruvate (+26%, p < 0.0001) and decreased L/P ratio (−13%, p < 0.0001) in patients overall (baseline-vs-supplementation over time), but no clear-cut change in 31P MRS PCr/ATP existed in our cohort (p > 0.4, supplemented-voxel-vs-contralateral voxel). However, the percentage decrease in L/P ratio for each patient following succinate perfusion correlated significantly with their percentage increase in PCr/ATP ratio (Spearman's rank correlation, r = −0.86, p = 0.024). Our findings support the interpretation that L/P ratio is linked to brain energy state, and that succinate may support brain energy metabolism in select TBI patients suffering from mitochondrial dysfunction.
Contiguous US summer maximum temperature and heat stress trends in CRU and NOAA Climate Division data plus comparisons to reanalyses
Authors: Grotjahn Richard , Huynh Jonathan 
Published: July 2018

AbstractWarming is a major climate change concern, but the impact of high maximum temperatures depends upon the air’s moisture content. Trends in maximum summertime temperature, moisture, and heat index are tracked over three time periods: 1900–2011, 1950–2011, and 1979–2011; these trends differ notably from annual temperature trends. Trends are emphasized from two CRU datasets (CRUTS3.25 and CRUTS4.01) and two reanalyses (ERA-20C and 20CRv2). Maximum temperature trends tend towards warming that is stronger over the Great Lakes, the interior western and the northeastern contiguous United States. A warming hole in the Midwest generally decreases in size and magnitude when heat stress trends are calculated because the region has increasing moisture. CRU and nearly all reanalyses find cooling in the northern high plains that is not found in NOAA Climate Division trends. These NOAA trends are captured better by CRUTS401. Moistening in the northeast amplifies the heat stress there. Elsewhere the moisture trends are less clear. Drying over northern Texas (after 1996) in CRUTS401 translates into decreasing heat stress there (less so in CRUTS325). Though other reanalyses are not intended for long-term trends, MERRA-2 and ERA-Interim match observed trends better than other reanalyses.
Whole genome SNP-associated signatures of local adaptation in honeybees of the Iberian Peninsula
Authors: Henriques Dora , Wallberg Andreas , Chávez-Galarza Julio , Johnston J. Spencer , Webster Matthew T. , Pinto M. Alice 
Published: July 2018

AbstractThe availability of powerful high-throughput genomic tools, combined with genome scans, has helped identifying genes and genetic changes responsible for environmental adaptation in many organisms, including the honeybee. Here, we resequenced 87 whole genomes of the honeybee native to Iberia and used conceptually different selection methods (Samβada, LFMM, PCAdapt, iHs) together within sillicoprotein modelling to search for selection footprints along environmental gradients. We found 670 outlier SNPs, most of which associated with precipitation, longitude and latitude. Over 88.7% SNPs laid outside exons and there was a significant enrichment in regions adjacent to exons and UTRs. Enrichment was also detected in exonic regions. Furthermore,in silicoprotein modelling suggests that several non-synonymous SNPs are likely direct targets of selection, as they lead to amino acid replacements in functionally important sites of proteins. We identified genomic signatures of local adaptation in 140 genes, many of which are putatively implicated in fitness-related functions such as reproduction, immunity, olfaction, lipid biosynthesis and circadian clock. Our genome scan suggests that local adaptation in the Iberian honeybee involves variations in regions that might alter patterns of gene expression and in protein-coding genes, which are promising candidates to underpin adaptive change in the honeybee.
Spontaneous formation of fluid escape pipes from subsurface reservoirs
Authors: Räss Ludovic , Simon Nina S. C. , Podladchikov Yury Y. 
Published: July 2018

AbstractUbiquitous observations of channelised fluid flow in the form of pipes or chimney-like features in sedimentary sequences provide strong evidence for significant transient permeability-generation in the subsurface. Understanding the mechanisms and dynamics for spontaneous flow localisation into fluid conductive chimneys is vital for natural fluid migration and anthropogenic fluid and gas operations, and in waste sequestration. Yet no model exists that can predict how, when, or where these conduits form. Here we propose a physical mechanism and show that pipes and chimneys can form spontaneously through hydro-mechanical coupling between fluid flow and solid deformation. By resolving both fluid flow and shear deformation of the matrix in three dimensions, we predict fluid flux and matrix stress distribution over time. The pipes constitute efficient fluid pathways with permeability enhancement exceeding three orders of magnitude. We find that in essentially impermeable shale (10−19 m2), vertical fluid migration rates in the high-permeability pipes or chimneys approach rates expected in permeable sandstones (10−15 m2). This previously unidentified fluid focusing mechanism bridges the gap between observations and established conceptual models for overcoming and destroying assumed impermeable barriers. This mechanism therefore has a profound impact on assessing the evolution of leakage pathways in natural gas emissions, for reliable risk assessment for long-term subsurface waste storage, or CO2 sequestration.
Weight loss and metabolic health effects from energy-restricted Mediterranean and Central-European diets in postmenopausal women: A randomized controlled trial
Authors: Bajerska Joanna , Chmurzynska Agata , Muzsik Agata , Krzyżanowska Patrycja , Mądry Edyta , Malinowska Anna M , Walkowiak Jarosław 
Published: July 2018

AbstractWe conducted a randomized controlled trial to examine the effect of two energy-restricted diets on body weight (BW), visceral fat (VF) loss, and the risk factors for metabolic syndrome. A total of 144 centrally obese postmenopausal women were assigned to the moderate in fat Mediterranean diet (MED) or to the Central European diet (CED), which is moderate in carbohydrates and high in dietary fiber (DF), for 16 weeks. BW, waist circumference and VF were significantly reduced by 8.8%, 7.0%, and 24.6%, respectively, over the trial (P < 0.001), with no difference between groups. A similar trend was seen for total cholesterol, triglycerides, glucose, and blood pressure. Within each diet group, the more adherent participants lost significantly more BW than did their less adherent counterparts. VF was significantly reduced only in women who were more adherent to the CED, and the reduction in VF correlated with an increase in the proportion of DF. Short-term dietary treatment with the CED or the MED was associated with similar improvements in some anthropometric, lipid, and nonlipid parameters; however, adequate adherence to the prescribed diet is important in weight loss success and in achieving improvements in metabolic health.
The association of the Hale sector boundary with RHESSI solar flares and active longitudes
Authors: Loumou K. , Hannah I. G. , Hudson H. S. 
Published: July 2018

Context. The heliospheric magnetic field (HMF) is structured into large sectors of positive and negative polarity. The parts of the boundary between these sectors where the change in polarity matches that of the leading-to-following sunspot polarity in that solar hemisphere, are called Hale sector boundaries (HSB).
Aims. We investigate the flare occurrence rate near HSBs and the association between HSBs and active longitudes.
Methods. Previous work determined the times HSBs were at solar central meridian, using the detection of the HMF sector boundary crossing at the Earth. In addition to this, we use a new approach which finds the HSB locations at all times by determining them from potential field source surface (PFSS) extrapolations of photospheric magnetograms. We use the RHESSI X-ray flare list for comparison to the HSB as it provides accurate flare locations over 14 years, from February 2002 to February 2016, covering both Cycles 23 and 24. For the active longitude positions we use previously published work based on sunspot observations.
Results. We find that the two methods of determining the HSB generally agree and that 41% (Cycle 23) and 47% (Cycle 24) of RHESSI flares occur within 30° of the PFSS determined-HSB. The behaviour of the HSBs varies over the two Cycles studied, and as expected they swap in hemisphere as the Cycles change. The HSBs and active longitudes do overlap but not consistently. They often move at different rates relative to each other (and the Carrington solar rotation rate) and these vary over each Cycle. The HSBs provide a useful additional activity indicator, particularly during periods when active longitudes are difficult to determine.
An atlas of cool supergiants from the Magellanic Clouds and typical interlopers
Authors: Dorda Ricardo , Negueruela Ignacio , González-Fernández Carlos , Marco Amparo 
Published: July 2018

We present an atlas composed of more than 1500 spectra of late-type stars (spectral types from G to M) observed simultaneously in the optical and calcium triplet spectral ranges. These spectra were obtained as part of a survey to search for cool supergiants in the Magellanic Clouds and were taken over four epochs. We provide the spectral and luminosity classification for each spectrum (71% are supergiants, 13% are giants or luminous giants, 4% are carbon or S stars, and the remaining 12% are foreground stars of lesser luminosities). We also provide a detailed guide for the spectral classification of luminous late-type stars, the result of the extensive classification work done for the atlas. Although this guide is based on classical criteria, we have put them together and re-elaborated them for modern CCD-spectra as these criteria were scattered among many different works and mainly conceived for use with photographic plate spectra. The result is a systematic, well-tested process for identifying and classifying luminous late-type stars, illustrated with CCD spectra of standard stars and the classifications of our own catalogue.
Giant burst of methanol maser in S255IR-NIRS3
Authors: Szymczak M. , Olech M. , Wolak P. , Gérard E. , Bartkiewicz A. 
Published: July 2018

Context. High-mass young stellar objects (HMYSOs) can undergo accretion episodes that strongly affect the star evolution, the dynamics of the disk, and its chemical evolution. Recently reported extraordinary bursts in the methanol maser emission may be the observational signature of accretion events in deeply embedded HMYSOs.
Aims. We analyze the light curve of 6.7 GHz methanol masers in S255IR-NIRS3 during the 2015–2016 burst.
Methods. 8.5-yr monitoring data with an average sampling interval of 5 days were obtained with the Torun 32 m radio telescope. Archival data were added, extending the time series to ~27 yr.
Results. The maser emission showed moderate (25–30%) variability on timescales of months to years over ~23 yr since its discovery. The main burst was preceded by a 1 yr increase of the total flux density by a factor of 2.5, then it grew by a factor of 10 over ~0.4 yr and declined by a factor of 8 during the consecutive 2.4 yr. The peak maser luminosity was a factor of 24.5 higher than the pre-burst quiescent value. The light curves of individual features showed considerable diversity but indicated a general trend of suppression of the maser emission at blueshifted (<4.7 km s−1) velocities when the redshifted emission rapidly grew and new emission features appeared at velocities >5.8 km s−1. This new emission provided a contribution of about 80% to the maser luminosity around the peak of the burst. The duration of the burst at the extreme redshifted velocities of 7.1–8.7 km s−1 was from 0.9 to 1.9 yr, and its lower limit for the other features was ~3.9 yr.
Conclusions. The onset of the maser burst exactly coincides with that of the infrared burst estimated from the motion of the light echo. This strongly supports the radiative pumping scheme of the maser transition. The growth of the maser luminosity is the result of an increasing volume of gas where the maser inversion is achieved.
Hildegard – ein Mythos?
Authors: Hildegard Von Bingen 
Published: July 2018

SummaryHistorische Quellen legen die Vermutung nahe, dass Hildegard von Bingen vielmehr eigenwillige Denkerin als Universalgelehrte war. Ob Dinkelbier oder Hildegard-Fasten: Viele Nahrungsmittel, Konzepte und Rezepte werden fälschlicherweise Hildegard zugeschrieben. Kaum bekannt ist, dass sich Hildegard intensiv der Heilwirkung von Bäumen, zum Beispiel Esskastanie, Olive und Birne, widmete.