bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Production Logging Tool Data PLT on Scale Squeeze Lifetime and Management of Scale Risk in Norwegian Subsea Production Wells – A Case Study
Authors: Jordan Myles 
Published: May 2019

Abstract
Due to the higher cost of scale management for subsea compared to platform or onshore fields, and because of the more limited opportunities for interventions, it is becoming increasingly important to obtain and utilise real production data from wells rather than estimated zone flow contribution from simple permeability (K) and height (h) models for scale squeeze treatment design.
This paper discusses how scale squeeze treatments were designed (coreflood evaluation of inhibitor retention/release) and deployed for three subsea heterogenous production wells. A permeability and layer height model were initially developed for each well based on detailed geological log data, estimated water/oil production rates and predicted water ingress location within the wells. Two of wells were each treated three times via bullhead scale squeeze treatments with effective scale control being reported over the designed lifetime. Prior to the fourth squeeze campaign of these two wells a production log was carried out and this information incorporated into the squeeze simulation to allow review of the ongoing third squeeze and enhance design accuracy for the upcoming fourth squeezes. A third well was treated twice before production logging data became available and the performance of treatments to this well is also assessed.
The production log data (PLT) proved very important in changing the understanding of fluid placement and location of water ingress during production resulting in changes to the isotherm values used to achieve effective history match to the inhibitor returns (with PLT data incorporated in all three wells) and most significantly impacting the squeeze lifetimes. Two of the treated wells were able to be significantly extended in their treatment lifetime (cumulative produced water to minimum inhibitor concentration) while the treatment life of one well was greatly reduced due to the PLT modified model predictions.
The paper outlines the process of reservoir/near wellbore modelling that is utilised for most initial squeeze treatments service companies deploy in the North Sea. It will highlight in detail the value that PLT data can provide to improve the effectiveness of the squeeze treatments in terms of understanding of fluid placement during squeeze deployment and water ingress location within heterogenous production wells. The intention of the paper is to highlight the value this type of data can provide to improve scale management (squeeze treatment and water shutoff) such that the value created more than offsets the cost of acquiring such information for subsea production wells.
A randomized controlled trial on the effect of remote ischemic preconditioning on ERK1, ERK2, STAT3 and STAT 5 in patients with and without diabetes mellitus undergoing CABG surgery
Authors: Brevoord Daniel , Smit Kirsten F. , Wang Yimming , Hollmann Markus W. , Kerindongo Raphaella P. , Weber Nina C. , Preckel Benedikt 
Published: May 2019

Abstract
Background Remote ischemic preconditioning (RIPC) is less effective in patients with diabetes, and the molecular mechanisms behind this lack of protection are not fully understood. In this study we investigated the effects of remote ischemic preconditioning on the intracellular signal cascade (known as the RISK pathway), e.g. ERK1/2, STAT3 and STAT5 in patients with and without diabetes undergoing coronary artery bypass graft (CABG) surgery. Methods Twenty-six patients with and 24 patients without diabetes mellitus undergoing CABG surgery under a total-intravenous, propofol based anesthetics regime, were randomized to either remote ischemic preconditioning induced by 3x 5 minutes of forearm ischemia or untreated controls. In each patient, two atrial tissue samples were collected: the first before, and the second after preconditioning, but before initiation of cardiopulmonary bypass. Tissue samples were homogenized and the ratio of total-to-phosphorylated ERK1 and 2, STAT 3 and STAT5 were determined by Western Blotting. Myocardial injury after CABG was assessed by analyzing postoperative troponin release. Results In the patients without diabetes, no effect of RIPC on any of the molecular markers was observed. In addition, we found no reduction in postoperative peak troponin release after RIPC. In patients with diabetes, ERK1 and ERK2 phosphorylation was increased in the control group, while in the RIPC treated patients only ERK2 was significantly increased. STAT3 phosphorylation was increased in both, the control and RIPC group, while there was no effect on STAT5 phosphorylation. Again, there was no effect on postoperative troponin release. Discussion We found no effect of RIPC on ERK 1, ERK2, STAT 3 or STAT 5 in either patients with or without diabetes. Additionally, there was no reduction in troponin T release by RIPC. The major limitation of our trial is the small sample size. Trial registration The trial was prospectively registered in the Dutch trial register as NTR1931.
Theme trends in research related to retinal vein occlusion: a quantitative and co-word analysis
Authors: Liu Fei , Chen Ximei , Zhao Miao 
Published: May 2019

Abstract
Background. This study focused on plotting knowledge structure and exploring research hotspots of retinal vein occlusion (RVO).
Methods. In this study, research articles, with subject of RVO, were acquired from PubMed. Bibliographic Item Co-Occurrence Matrix Builder (BICOMB) was used for MeSH terms acquisition, evaluation and high-frequency MeSH term determination. Biclustering analysis and knowledge structure were conducted based on the MeSH term-source article matrix. RVO theme trends were illustrated with social network analysis (SNA), along with strategic diagrams.
Results. A total of 3179 articles on RVO were retrieved, and the annual research output increased with time. USA ranked first with the most publications, with Retina as the most prolific journal in RVO research. MeSH terms were characterized into five different genres. As shown by the strategic diagram, the complications of RVO, the etiology of macular edema, as well as the therapeutic use of anti-VEGF, steroids and anti-inflammatory agents were well developed (Quadrant I). In contrast, epidemiology, metabolism and genetics related research on RVO were relatively immature (Quadrant III). Research on surgical treatments of vitrectomy, diagnostic methods and pathology of RVO were centralized but undeveloped (Quadrant IV). The SNA results was exhibited by the centrality chart, on which the node position was represented by the centrality values.
Conclusions. By providing a bibliometric research, the overall RVO research trends could be revealed based on the five categories identified by this study. The mathematical bibliometric study could shed light on new perspectives for researchers.
Biological proprieties of Pasteurella multocida isolate from sheep in Morocco
Authors: Boumart zineb , Bamouh Zahra , Jazouli Mohammed , Rafie Lamya , Tadlaoui Khalid Omari , Harrak Mehdi EL 
Published: May 2019

Abstract
Background
In Morocco, observations of pasteurellosis clinical cases reported by field veterinarian and lesions observed in abattoirs, suggest circulation of serotypes of pasteurellosis among small ruminants population. However, little is known on the prevalence of the main serotypes in this region and their pathogenicity.
Results
We investigated five suspected Pasteurella clinical cases from different provinces of Morocco. We succeeded to isolate 2 strains (S14 and S13) of Pasteurella Multocida A among the five isolates. Identification was achieved by biochemical and molecular biology methods. Phylogeny based on two genes sequence analysis (RNA16S and rpoB) suggested that the two isolates present similarity with others from different species. A pathogenicity study was conducted in mice, guinea pigs and sheep to set up a model for vaccine testing. The strain S14 was more virulent than S13 in laboratory animals and induced severe illness in sheep.

Conclusion
The high mortality of infected mice suggest that this animal may represent a good alternative for testing pathogenicity and vaccine efficacy.
Giant pseudoaneurysm of aorta and aortobronchial fistula after surgery for aortic re-coarctation
Authors: Kornilov I. A. , Sinelnikov Yu. S. , Soynov I. A. , Ivantsov S. M. , Nichay N. R. , Omelchenko A. Yu. , Gorbatykh Yu. N. , Voitov A. N. 
Published: May 2019

<div data-canvas-width="623.7618176418355">Aortobronchial fistula is a rare but potentially fatal complication after balloon plasty of aortic coarctation. We present a case of successful single-stage correction of giant pseudoaneurysm of the aortic arch with aortobronchial fistula in a 6-year-old patient after aortic arch replacement, which developed as a result of avulsion of the synthetic graft from the aortic wall when performing balloon angioplasty of a narrowed part of the aorta.</div><div data-canvas-width="623.7618176418355"><div data-canvas-width="195.17408019374872"> </div><div data-canvas-width="195.17408019374872">Received 15 April 2015. Accepted 30 April 2015.</div><div> </div></div>
Efficacy and safety of bioresorbable vascular scaffold Absorb: 6-month outcomes of GABI-R: Russia registry
Authors: Prokhorikhin A. , Fartakov E. , Malaev D. , Boykov A. , Oidup-Ool S. , Baystrukov V. , Grazhdankin I. , Zubarev D. , Pokushalov E. , Kretov E. 
Published: May 2019

Aim. The paper demonstrates the interim analysis of efficacy and safety after everolimus-eluting bioresorbable vascular scaffold (BVS) Absorb implantation in “real-world patients” with coronary artery disease.Methods. A cohort of 500 consecutive patients who underwent percutaneous coronary intervention for stable chest pain or acute coronary syndrome with implantation of at least one BVS (Absorb, Abbott Vascular) and followed up by telephone interview and review of medical charts were included in a singlecenter, prospective, all-comers, first in Russia registry. The primary endpoint, target vessel failure, defined as the combination of cardiac death, target vessel myocardial infarction, or clinically driven target vessel revascularization and secondary endpoints, MACCE (composite of cardiovascular death, myocardial infarction, coronary artery bypass surgery, target vessel revascularization, stroke) and stent thrombosis, were assessed during 6-month follow-up.Results. A total of 500 patients with coronary artery disease (CAD) (stable CAD 54.4%, acute coronary syndrome 45.6%) and different amount of affected vessels (1 vessel CAD 40.8%, n = 204; 2-vessel CAD 32.8%, n = 164; 3-vessel CAD 26.4%, n = 132) received 664 scaffolds and 55 stents in 603 stenoses. Procedure success, defined as a residual stenosis less than 30% and TIMI 3 flow in target vessel at the end of procedure, was observed in 98.51% (n = 594). At the moment of 6-month follow-up 4.2% (n = 24) of patients were lost to contact. After 6 months, incidence of target vessel failure and MACCE was 4.2% (n = 21) and 5% (n = 25). The cumulative rate of definite/probable scaffold thrombosis was 1.6% (n = 8).Conclusion. The interim analysis of Gabi-R: Russia registry, the largest trial of BVS Absorb implantation in routine clinical practice, showed high procedural success and low incidence of adverse events during follow-up. However, a tendency to high incidence of scaffold thrombosis compared to drug-eluting stents can be observed. Considering the long-term results of randomized trials retrospective registries, safety in terms of BVS routine use is of big concern. Longterm 24-month data regarding safety endpoints are required to test the afore-mentioned suggestion. Received 5 January 2019. Revised 28 March 2019. Accepted 29 March 2019.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.
Connected Speech Deficit as an Early Hallmark of CSF-defined Alzheimer’s Disease and Correlation with Cerebral Hypoperfusion Pattern
Authors: Mazzon Giulia , Ajčević Miloš , Cattaruzza Tatiana , Menichelli Alina , Guerriero Michele , Capitanio Selene , Pesavento Valentina , Dore Franca , Sorbi Sandro , Manganotti Paolo , Marini Andrea 
Published: May 2019

Background:
Diagnosis of prodromal Alzheimer's disease (AD) still represents a hot topic and
there is a growing interest for the detection of early and non-invasive biomarkers. Although progressive
episodic memory impairment is the typical predominant feature of AD, communicative difficulties can be
already present at the early stages of the disease.

Objective:
This study investigated the narrative discourse production deficit as a hallmark of CSFdefined
prodromal AD and its correlation with cerebral hypoperfusion pattern.

Method:
Narrative assessment with a multilevel procedure for discourse analysis was conducted on 28
subjects with Mild Cognitive Impairment (15 MCI due to AD; 13 MCI non-AD) and 28 healthy controls.
The diagnostic workup included CSF AD biomarkers. Cerebral hypoperfusion pattern was identified by
SPECT image processing.

Results:
The results showed that the discourse analysis of global coherence and lexical informativeness
indexes allowed to identify MCI due to AD from MCI non-AD and healthy subjects. These findings allow
to hypothesize that the loss of narrative efficacy could be a possible early clinical hallmark of Alzheimer’s
disease. Furthermore, a significant correlation of global coherence and lexical informativeness
reduction with the SPECT hypoperfusion was found in the dorsal aspect of the anterior part of the left
inferior frontal gyrus, supporting the hypothesis that this area has a significant role in communicative
efficacy, and in particular, in semantic selection executive control.

Conclusion:
This study contributes to the understanding of the neural networks for language processing
and their involvement in prodromal Alzheimer's disease. It also suggests an easy and sensitive tool for
clinical practice that can help identifying individuals with prodromal Alzheimer’s disease.
Plasma Membrane Proteomic Profile Discovers Macrophage-capping Protein Related to Latent HIV-1
Authors: Zhang Yujiao , Shen Yinzhong , Yin Lin , Qi Tangkai , Jia Xiaofang , Lu Hongzhou , Zhang Lijun 
Published: May 2019

Background:Due to the persistence of latent HIV-infected cellular reservoirs, HIV virus can not be eradicated completely.Objective:To identify proteins related to HIV latency, we performed a subcellular proteomic study in HIV latent cell lines.Method:An established HIV-1 latent cell model (J-Lat Tat-GFP Clone A7 cells, A7 cells) and its parental cell line (Jurkat cells) were used. The plasma membrane (PM) fraction from cultured cells was enriched through aqueous two-phase partition. PM proteins were extracted and then separated using two-dimensional electrophoresis (2DE). Differentially expressed proteins were identified by mass spectrometry, and verified by western blotting.Results:Thirteen non-redundant proteins were identified to be differentially expressed in the A7 PM fraction compared to those in the Jurkat PM. Eight had a PM location through Gene Ontology (GO) analysis. A differential protein network of CAPG-ACTR3-CD3D was detected to have interactions with HIV Vpr, Tat, gp160, etc. through STRING software analysis. One of the differential proteins (Macrophage-capping protein (CAPG)) was verified by western blotting to be down- regulated in two cell lines and HIV resting CD4+ T cells negatively selected from patients.Conclusion:We identified 13 proteins in A7 compared to Jurkat cells. CAPG may be a potential biomarker related to HIV latency.
In Vitro Evaluation of Chitosan Induced Cytotoxicity against Cancerous Cell lines: MCF-7, Saos-2 and HeLa
Authors: Abedian Zeinab , Jenabian Niloofar , Moghadamnia Ali Akbar , Zabihi Ebrahim , Pourbagher Roghayeh , Ghasemi Masoumeh , Nouri Hamid Reza 
Published: May 2019

Objective/ Background:
Cancer is still the most common cause of morbidity in world and new powerful anticancer agents without severe side effects from natural sources is important.

Methods:
The evaluation of cytotoxicity and apoptosis induction was carried out in MCF-7,HeLa and Saos-2 as cancerous cell lines with different histological origin and human fibroblast served as control normal cell. The cells were treated with different concentrations of chitosan and the cytotoxicity was determined using MTT assay after 24, 48 and 72 h .The mode of death was evaluated by flow cytometry .

Results:
While both types of chitosan showed significant concentration-dependently cytotoxic effects against the three cancerous cell lines, fibroblast cells showed somehow more compatibility with chitosan. On the other hand, there were no significant differences between LMWC and HMWC cytotoxicity in all cell lines. The flow cytometry results showed the apoptosis pattern of death more in Saos-2 and HeLa while necrosis was more observable with MCF7. Also higher viability with both types of chitosan was seen in fibroblast as normal cells

Conclusion:
Chitosan shows anticancerous effect against 3 cancerous cell lines, while it is compatible with normal diploid fibroblast cells. Furthermore, it seems that the molecular weight of chitosan does not affect its anticancerous property.
Hemodynamic Changes of Hepatic & Renal Vessels in Systemic Bacterial Infection with Fever in HCV Related Cirrhosis
Authors: Helal Eman Mohammed , Sharaf-Eldin Mohamed , Abou El Azm Abdel Raouf , Badr Eldin Nagwa Mansour , Dawoud Mohammed Mahmoud , Abd-Elsalam Sherief , Ziada Dina Hazem 
Published: May 2019

Objective:
To study the hemodynamic changes of hepatic & renal vessels in systemic
bacterial infection with fever in HCV related cirrhosis with possible complications.

Methods:
Three groups of patients with systemic bacterial infection with fever were included in
the study; group І included 15 patients with decompensated cirrhosis, group ІІ included 15 patients
with compensated cirrhosis and group ІІІ included 10 patients without liver affection. Laboratory
parameters and Doppler US of hepatic and renal vessels were evaluated during and after
subsidence of fever in all patients.

Results:
Forty patients were enrolled in this prospective study. There were 22 male and 18 female
patients. We found that the direction of blood flow in the portal and splenic veins was hepatopetal
and the veins were non pulsatile in all cases with no change during and after subsidence of infection.
There was no significant difference in portal or splenic vein diameters during and after subsidence
of infection in the three studied groups. However, the mean values of portal and splenic
veins peak velocities were significantly lower during infection in cirrhotic groups. The mean value
of hepatic artery resistive index during fever was significantly higher than after fever in cirrhotic
groups. Renal resistive and pulsatility indices were significantly higher during fever in cirrhotic
groups.

Conclusion:
Systemic bacterial infection with fever can affect hepatic haemodynamics leading to
aggravation of portal hypertension and increasing the risk of complications as variceal bleeding
and hepatic encephalopathy and can also affect renal haemodynamics with increased risk of renal
impairment.
La labor del tutor con los alumnos de B@UNAM en el extranjero Gabriela Miranda Navarro*
Authors: Navarro Gabriela Miranda 
Published: May 2019

En el presente escrito se describe, a grandes rasgos, la labor del tutor en el programa de bachillerato a distancia de la UNAM (B@UNAM) en el extranjero, cuyo propósito principal es ser un acompañante permanente para el alumno, un acompañante que le brindará un seguimiento puntual en su formación y que pretenderá, ante todo, mantener la motivación académica y personal del alumno durante su permanencia en el bachillerato.
Economía creativa, sostenibilidad y su relacion de futuros deseables
Authors: Deheinzelin Lala 
Published: May 2019

<p>¿Por qué la economía creativa es la llave del desarrollo sostenible y cuáles son los beneficios de las industrias creativas? ¿Qué función desempeñan las nuevas tecnologías para facilitar este proceso y generar modelos innovadores? ¿Cuál es su aportación como elemento catalizador de futuros deseables? El artículo aborda estos temas a partir de la innovación, los cambios de mentalidad y hábitos, a partir de visiones de futuro compartidas.</p>
Pelatihan dan Pendampingan Pembuatan Media Simulasi Praktikum IPA SMP dengan Program Simulasi Phet
Authors: Sujanem Rai , Sutarno Erwan , Aris Gunadi I Gede 
Published: May 2019

Tujuan kegiatan pelatihan ini adalah sebagai berikut. 1) Meningkatkan pengetahuan dan keterampilan guru-guru IPA SMP untuk membuat media simulasi praktikum IPA dengan program PhET. 2) Guru-guru IPA SMP dapat mengimplementasikan media simulasi praktikum IPA dengan program PhET dalam proses pembelajaran IPA. Peserta pelatihan adalah guru-guru IPA SMPN 1 Sukasada, SMP Negeri 1, 2, 3, 4, 5 Singaraja, dan SMP Lab Undiksha Singaraja. Jumlah peserta adalah 15 orang. Prosedur kegiatannya melalui pelatihan dan pendampingan pembuatan media simulasi praktikum IPA dengan program PhET. Hasil pelatihan menunjukkan bahwa 1) peserta pelatihan telah memiliki pengetahuan dan keterampilan untuk membuat media simulasi praktikum IPA dengan program PhET, 2) peserta pelatihan dapat mengimplementasikan media simulasi praktikum IPA dengan program PhET dalam pembelajaran di kelas. Berdasarkan uraian ini, dapat disimpulkan bahwa para peserta pelatihan telah dapat membuat media simulasi praktikum IPA dengan program PhET dan dapat mengimplementasikan dalam pembelajaran IPA di kelas
Sharing linked data sets for research: results from a deliberative public engagement event in British Columbia, Canada
Authors: Teng Jack , Bentley Colene , Burgess Michael M , O'Doherty Kieran C , McGrail Kimberlyn M 
Published: May 2019

IntroductionResearch using linked data sets can lead to new insights and discoveries that positively impact society. However, the use of linked data raises concerns relating to illegitimate use, privacy, and security (e.g., identity theft, marginalization of some groups). It is increasingly recognized that the public needs to be consulted to develop data access systems that consider both the potential benefits and risks of research. Indeed, there are examples of data sharing projects being derailed because of backlash in the absence of adequate consultation. (e.g., care.data in the UK).
Objectives and methodsThis paper describes the results of a public deliberation event held in April 2018 in Vancouver, British Columbia. The purpose of this event was to develop informed and civic-minded public advice regarding the use and the sharing of linked data for research with a focus on the processes and regulations employed to release data. The event brought together 23 members of the public over two weekends.
ResultsParticipants developed and voted on 19 policy-relevant statements. Voting results and the rationale behind any disagreements are reported here. Taken together, these statements provide a broad view of public support and concerns regarding the use of linked data sets for research and offer guidance on measures that can be taken to improve the trustworthiness of policies and process around data sharing and use.
ConclusionsGenerally, participants were supportive of research using linked data because of the value they provide to society. Participants expressed a desire to see the data access request process made more efficient to facilitate more research, as long as there are adequate protections in place around security and privacy of the data.