bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic profile of plasma-derived extracellular vesicles from Colombian pregnant women with Plasmodium-soil transmitted helminths coinfection
Authors: Martínez-Moreno Jahnnyer A. , Ayllon-Hermida Alberto , Barnadas-Carceller Berta , Fernández-Becerra Carmen , del Portillo Hernando A. , Carmona-Fonseca Jaime , Arango-Flórez Eliana M. 
Published: November 2024

IntroductionExtracellular vesicles (EVs) are lipid bilayer membrane-enclosed nanoparticles, secreted by all cell types. Information regarding EVs and their molecular cargo in gestational parasitic infections, particularly those caused by Plasmodium and soil-transmitted helminths (STH), remains largely unexplored. This study aimed to perform isolation and molecular characterization of plasma-derived EVs from Colombian pregnant women and compare quantity, size, concentration and protein cargo of those EVs according to the infectious status, to investigate if parasite-derived proteins could be detected as biological cargo of circulating EVs of pregnant women infected with Plasmodium, STH and co-infections.Materials and methodsA descriptive study with 5 groups was performed: 1) Pregnant women with Plasmodium infection (n=10). 2) Pregnant women with STH infection (n=14). 3) Pregnant women with coinfection Plasmodium and STH (n=14). 4) Pregnant women without infection with Plasmodium nor STH (n=10). 5) Non-pregnant women without infection with Plasmodium nor STH (n=6). Plasma-derived EVs were isolated by size exclusion chromatography (SEC) and fractions containing EVs identified by a bead-based flow cytometric assay for CD9; the size and concentration of EVs were quantified by nanoparticle tracking analysis, and proteins associated with EVs were identified by liquid chromatography-mass spectrometry in a pool of samples per study group.ResultsThere were no statistical differences in expression of the CD9 EVs marker among study groups. The size range of EVs was more variable in the three infected groups (100-700 nm) compared to the size range of the uninfected groups (50-300 nm). A total of 823 quantifiable proteins with measurable abundance values were identified within the five study groups. Of the total quantifiable proteins, 758 were identified as human, six proteins pertained to P. vivax, fifteen to Trichiuris trichiura, and one to hookworms. Data are available via ProteomeXchange with identifier PXD051270.DiscussionThis is the first study that identifies proteins from Plasmodium and STH in EVs isolated from pregnant women. The identification of such proteins from neglected tropical parasites accounting for a major burden of disease worldwide, open the possibilities of studying their physiological role during infections as well as exploring them for antigen discovery, vaccine development and biomarker discovery.
Association between platelet-to-red cell distribution width ratio and all-cause mortality in critically ill patients with non-traumatic cerebral hemorrhage: a retrospective cohort study
Authors: Lu Rongrong , Wu Changcai 
Published: November 2024

BackgroundThe purpose of this study was to investigate the relationship between platelet-to-red cell distribution width ratio (PRR) and all-cause mortality in critically ill patients with non-traumatic cerebral hemorrhage (NCH).MethodsThe Medical Information Mart for Intensive Care (MIMIC-IV) database was used to identify patients with NCH who needed to be admitted to intensive care unit (ICU). The outcomes of the study included both ICU and in-hospital mortality. Restricted cubic splines and Cox proportional hazards regression analysis were used to clarify the relationship between PRR and clinical outcomes in critically ill patients with NCH.ResultsA total of 3,094 patients (54.0% male) were included in the study, with in-hospital mortality and ICU mortality rates of 16.5 and 11.8%, respectively. A substantial correlation was found by multivariate Cox proportional hazards analysis between increased PRR and a lower risk of in-hospital and ICU mortality. Following adjustment for confounding factors, patients with elevated PRR exhibited a significantly decreased risk of in-hospital death (HR, 0.98; 95% CI, 0.96–0.99; p = 0.006) and ICU death (HR, 0.98; 95% CI, 0.96–0.99; p = 0.027). As PRR increased, restrictive cubic splines showed a progressive decrease in the probability of all-cause mortality. Stratified analyses indicated a consistent association between PRR and both in-hospital and ICU mortality.ConclusionAmong critically ill patients with NCH, lower PRR was substantially correlated with the increased probability of all-cause mortality in both the ICU and hospital. According to this research, PRR might be a valuable indicator for identifying NCH patients at risk of all-cause mortality.
Examining the relationship between CDAI and frailty and its manifestation in Parkinson’s disease: a cross-sectional study
Authors: Zeng Zhaohao , Jin Wen , Huang Kunyu , Xiong Lijiao , Luo Yu , Li Guoyang , Zhang Wenli , Hong Guo , Mao Fengju , Xiong Kaifen , Luo Xiaoguang 
Published: November 2024

BackgroundHigher intake of antioxidants is associated with reduced risk of various chronic diseases. However, the relationship between composite dietary antioxidants and frailty has not been characterized, especially in neurodegenerative conditions like Parkinson’s disease (PD) where frailty is highly prevalent. This study aimed to investigate the association between composite dietary antioxidant index (CDAI), a composite score reflecting antioxidant vitamin and mineral intakes, and frailty risk in the general United States (US) population and PD patients.MethodsData from 21,354 participants ≥40 years in the National Health and Nutrition Examination Survey (NHANES) 2003–2018 represented the general population sample, while 268 PD patients were analyzed separately. Frailty was defined using a validated index. Weighted logistic regression and restricted cubic splines (RCS) examined overall and nonlinear CDAI-frailty associations, adjusting for sociodemographics, lifestyle factors, and comorbidities.ResultsIn the general population, each unit increase in CDAI was associated with a 3.7% lower likelihood of frailty after full adjustments. Vitamin A, C, E, selenium and carotenoids exhibited J-shaped relationships where frailty risk decreased below intake thresholds of 1093.04 μg, 161.53 mg, 13.66 mg, 109.99 μg, and 5057.50 μg, respectively. In contrast, the CDAI- frailty inverse association was weaker among PD patients and only vitamin C (threshold 52.45 mg) and zinc (9.35 mg) showed nonlinear links.ConclusionHigher dietary antioxidant intake was associated with lower frailty prevalence in the general US population, with vitamins A, C, E, selenium, and carotenoids exhibiting nonlinear J-shaped relationships. In contrast, these associations were weaker and less consistent among PD patients, with only vitamins C and zinc showing nonlinear correlations. These findings highlight population-specific differences in the role of dietary antioxidants in frailty and suggest the need for personalized nutritional strategies in PD frailty management.
Safety and usability of oncology information systems – a systematic review
Authors: Cihoric Nikola , Riggenbach Elena , Putora Paul Martin , Dennstädt Fabio 
Published: November 2024

BackgroundDigitalization has become integral to healthcare and specifically cancer treatment. Healthcare providers in oncology widely use electronic data collection and management systems in contemporary clinical practice. However, some reports point to severe problems regarding usability, which negatively impact the clinical workforce, as well as safety issues related to electronic health records, which potentially endanger patients. This systematic review aims to evaluate current scientific literature on the usability and safety aspects of electronic health records in oncology.MethodsWe conducted a systematic literature review on PubMed and Scopus to identify articles on the usability and safety aspects of electronic health records and clinical information systems utilized in oncological care. Two authors independently evaluated available literature according to predefined inclusion and exclusion criteria. Finally, we quantitatively analyzed and classified the reported findings.ResultsOur literature research strategy retrieved 1032 articles. We included seven articles for further processing. Three projects focused on the assessment of electronic health record functionality, three projects described the process of user-driven design, and one article described remediation procedures introduced to compensate inability of computer systems to adapt to user requirements.ConclusionLiterature on the usability and safety of electronic health records in oncology is sparse. It is essential to raise awareness and start systematic activity to promote research on the usability of electronic health records in oncology.
Yishen paidu pills attenuates 5/6 nephrectomy induced kidney disease via inhibiting the PI3K/AKT/mTOR signaling pathway
Authors: Liu Saiji , Cao Yiling , Yuan Qian , Xie Yaru , Zhu Yuting , Yao Lijun , Zhang Chun 
Published: November 2024

IntroductionChronic kidney disease (CKD) is a substantial global health issue with high morbidity and mortality. Yishen Paidu Pills (YSPDP) are effective concentrated water pills composed of four herbs developed by Wuhan Union Hospital to treat CKD. However, the mechanism of YSPDP action is largely unknown. This study combined metabolomics, network pharmacology, transcriptomics, and experimental verification to elucidate and identify the effects and potential mechanisms of YSPDP against CKD.MethodsFirstly, we used metabolomics analyses to identify the chemical components of YSPDP. Then, network pharmacology was conducted and indicated the predicted signaling pathways regulated by YSPDP. Next, we conducted a 5/6 subtotal nephrectomy (5/6 SNx) rat model and treated these rats with YSPDP or Losartan for 10 weeks to evaluate the effect of YSPDP on CKD. To further analyze the underlying mechanism of YSPDP in CKD, the kidney tissues of 5/6 SNx rats treated with vehicle and YSPDP were performed with transcriptome sequencing. Finally, the western blot was performed to validate the signaling pathways of YSPDP against CKD.ResultsTwenty-four classes of chemicals were identified by metabolomics in YSPDP. YSPDP markedly hindered CKD progression, characterized by the restoration of body weight and serum albumin levels, improved renal function, diminished tissue injury, and hampered renal fibrosis in 5/6 SNx rats. The efficacy of YSPDP in ameliorating the progression of CKD was comparable to that of losartan. Furthermore, network pharmacology, transcriptomics, and functional enrichment analysis indicated the PI3K/AKT/mTOR signaling pathway was the key pathway regulated by YSPDP. Western blot validated the inhibition of PI3K/AKT/mTOR signaling in the kidney of 5/6 SNx rats treated by YSPDP.ConclusionThe study identified the chemicals of YSPDP and revealed that YSPDP prevented the progression of CKD by inhibiting PI3K/AKT/mTOR signaling in 5/6 SNx rats.
Development of the dementia attitude scale focusing on well-being
Authors: Ono Ichie , Nakatani Hisae , Inoue Yuriko , Peng Xuxin , Hamada Hironobu 
Published: November 2024

IntroductionThis study aimed to develop the Dementia Attitude Scale Focusing on well-being (DASFWB) and to verify its reliability and validity. This scale measures the factors that individuals without dementia would consider important for their well-being if they were to develop dementia. It is expected to serve as a useful indicator for intervention strategies aimed at achieving an inclusive society.MethodsThe draft DASFWB scale was developed by extracting stories from older adults with mild Alzheimer's disease. The questionnaire was distributed to 1,614 adults aged 65 and older who were able to complete the self-administered questionnaire. Data from 815 individuals who completed the questionnaire without help (58.8% valid response rate) were analyzed. Exploratory and confirmatory factor analyses were performed to identify the factors underlying the scale. Reliability was tested using Cronbach's alpha. Validity was tested through sample, criterion-related, convergent, and discriminant validity.ResultsThe development and validation of the DASFWB identified a three-factor, 12-item scale. Cronbach's alpha coefficients for the scale and its three factors were 0.857, 0.843, 0.723, and 0.644, respectively. The confirmatory factor analysis model indices were as follows: χ2 = 146.574, df = 51, p &lt; 0.001, comparative goodness of fit index = 0.930, goodness of fit index = 0.945, Tucker-Lewis index = 0.909, and root mean square error of approximation = 0.068. The composite reliability value for convergent validity, which was &gt;0.7, was higher than the average variance extracted value. The criterion-related validity showed a weak correlation (ρ = −0.245 to 0.341, p &lt; 0.001).DiscussionThe DASFWB exhibits good reliability and validity, indicating its utility as a measuring instrument.
Validation of food frequency questionnaire for food intake of adults in Gida, West, Ethiopia
Authors: Fikadu Worku , Mulugeta Segni , Dejene Yeshimebet 
Published: November 2024

BackgroundDiet is characterized by complex exposure to strongly intercorrelated components. Early efforts to understand diet-disease associations focused on the role of specific nutrients, but later, it became evident that dietary exposures may act synergistically in several instances. For research into how nutrition affects health and disease, scientifically sound descriptions of dietary intake at the population level are essential. Although food frequency questionnaires are important nutritional assessment methods, they should be validated and checked for reliability according to the eating habits of the specific population. Context-specific tools are needed to estimate food intake accurately, but a single study in Ethiopia has not established reliability. Hence, this study aimed to establish a valid and feasible dietary assessment method for 24-h dietary recall.ObjectiveTo adapt and validate FFQs for use as dietary assessment tools in epidemiological studies among adults in Gida woreda, West Ethiopia.MethodA community-based cross-sectional study was conducted from February 15–30, 2023, among 150 participants. Data were collected through an interviewer-administered questionnaire, a focus group discussion, and a key informant interview. We compared the mean of three interactive 24-h dietary recalls to the FFQ to assess its relative validity. By comparing food category levels, mean differences, medians, and cross-classifications from the FFQ and a 24-h dietary recall, validity was assessed.ResultsThe response rate of this study was 100% for both the FFQ and 24-item dietary recall. The mean (±SD) age of the participants was 37.6 9.7 years. Of the total participants, 40 (29%) were between 31 and 35 years old. Sixty-four (42%) of the study participants were protestant religious followers. The median ranges from zero for meat and poultry to 1,930 for cereal, as estimated by the 24-h dietary recall method. The median ranges from 14 mg/day for meat and poultry to 724 mg/day for cereal, as estimated by the FFQ.ConclusionThis study revealed that this food frequency questionnaire had good validity for capturing the intake of food groups which indicated by their value: vegetables (0.8), legumes (0.9), roots/tubers (0.8), cereal (0.5), dairy products (0.75), and meat/poultry (0.64) at both the individual and group levels. Hence, it is recommended for health care providers to use FFQ as a tool for studying and managing dietary-related diseases.
Analysis of effects of meteorological variables on dengue incidence in Bangladesh using VAR and Granger causality approach
Authors: Hossain Md. Jamal , Sultana Nazia , Das Anwesha , Jui Fariea Nazim , Islam Md. Kamrul , Rahman Md. Mijanoor , Rahman Mohammad Mafizur 
Published: November 2024

BackgroundDengue fever is a serious public health issue in Bangladesh, where its incidence rises with the monsoon. Meteorological variables are believed to be responsible factors among others. Therefore, this study examines the effects of meteorological variables (temperature, rainfall, and humidity) on dengue incidence in Bangladesh. While previous studies have examined the relationship between dengue and meteorological variables using single model approaches, this study employs advanced econometric techniques to capture dynamic interactions. Furthermore, in the case of Bangladesh, this type of analysis is necessary due to the fact that dengue outbreak become one of the major issues. However, the analysis related to this issue is not available.MethodsFor estimation purposes, the Augmented Dickey-Fuller (ADF) test, Vector Autoregressive (VAR) model, Granger causality tests, Impulse Response Function (IRF), Variance Decomposition (VDC), and Vector Error Correction Model (VECM) are employed.ResultsRainfall has a significant impact on dengue incidence compared to temperature and humidity. The Granger causality test demonstrates that rainfall and dengue incidence are causally related unidirectionally. Rainfall can potentially have a short-term and long-term effect on the incidence of dengue, as per the estimates of the VECM model.ConclusionsThese findings will assist policymakers in Bangladesh in developing a dengue fever early warning system depending on climate change. In order to efficiently avoid the spread of dengue in Bangladesh's dengue-endemic urban areas, this study suggests societal monitoring.
Socially interactive agents for robotic neurorehabilitation training: conceptualization and proof-of-concept study
Authors: Arora Rhythm , Prajod Pooja , Nicora Matteo Lavit , Panzeri Daniele , Tauro Giovanni , Vertechy Rocco , Malosio Matteo , André Elisabeth , Gebhard Patrick 
Published: November 2024

IntroductionIndividuals with diverse motor abilities often benefit from intensive and specialized rehabilitation therapies aimed at enhancing their functional recovery. Nevertheless, the challenge lies in the restricted availability of neurorehabilitation professionals, hindering the effective delivery of the necessary level of care. Robotic devices hold great potential in reducing the dependence on medical personnel during therapy but, at the same time, they generally lack the crucial human interaction and motivation that traditional in-person sessions provide.MethodsTo bridge this gap, we introduce an AI-based system aimed at delivering personalized, out-of-hospital assistance during neurorehabilitation training. This system includes a rehabilitation training device, affective signal classification models, training exercises, and a socially interactive agent as the user interface. With the assistance of a professional, the envisioned system is designed to be tailored to accommodate the unique rehabilitation requirements of an individual patient. Conceptually, after a preliminary setup and instruction phase, the patient is equipped to continue their rehabilitation regimen autonomously in the comfort of their home, facilitated by a socially interactive agent functioning as a virtual coaching assistant. Our approach involves the integration of an interactive socially-aware virtual agent into a neurorehabilitation robotic framework, with the primary objective of recreating the social aspects inherent to in-person rehabilitation sessions. We also conducted a feasibility study to test the framework with healthy patients.Results and discussionThe results of our preliminary investigation indicate that participants demonstrated a propensity to adapt to the system. Notably, the presence of the interactive agent during the proposed exercises did not act as a source of distraction; instead, it positively impacted users' engagement.
Исследование конфигураций нейросетевых кодеков для адаптивной системы сжатия кадров FPV-видеопотока при управлении беспилотными системами. Часть II. Эксперимент
Authors: А.А. Березкин , А.А. Ченский , Р.В. Киричек , А.А. Захаров 
Published: November 2024

В данной работе исследованы различные конфигурации нейросетевых кодеков, разработанных на основе вариационных автокодировщиков вида VQ и KL (VQ-f4, VQ-f8, VQ-f16, KL-f4, KL-f8, KL-f16, KL-f32) из состава моделей Stable Diffusion, на предмет возможности их использования для сжатия кадров видеопотока при FPV управлении беспилотными системами. Обобщаются исследования, проведённые для автокодировщика VQ-f16. Во второй части статьи рассматривается адаптация алгоритмов квантования и сжатия для латентного пространства признаков вариационных автокодировщиков видов VQ и KL, проводится оценка соотношений степеней сжатия и метрик качества восстанавливаемого изображения для вариационных автокодировщиков при различных конфигурациях нейросетевого кодека, определяются наилучшие методы обработки латентного пространства для каждого вариационного автокодировщика, а также проводится оценка целесообразности использования каждого из вариационных автокодировщиков. Разработаны предварительные конфигурации нейросетевого кодека для использования в различныхусловиях. Полученные результаты показывают возможности применения вариационных автокодировщиков в нейросетевых кодеках, используемых в каналах передачи видеопотока между внешним пилотом и беспилотной системой.
In this work, we investigate various configurations of neural network codecs developed on the basis of variational autoencoders of the VQ and KL types (VQ-f4, VQ-f8, VQ-f16, KL-f4, KL-f8, KL-f16, KL-f32) from the Stable Diffusion models for the possibility of their use for video stream frame compression in FPV control of unmanned systems. We summarize the studies conducted for the VQ-f16 autoencoder. The second part of the article considers the adaptation of quantization and compression algorithms for the latent feature space of variational autoencoders of the VQ and KL types, evaluates the ratios of compression rates and quality metrics of the reconstructed image for variational autoencoders with various configurations of the neural network codec, determines the best methods for processing the latent space for each variational autoencoder, and evaluates the feasibility of using each of the variational autoencoders. Preliminary configurations of the neural network codec for use in various conditions have been developed. The results obtained demonstrate the possibility of using variational autoencoders in neural network codecs used in video stream transmission channels between an external pilot and an unmanned system.
Влияние подстилающей поверхности на эффективность работы средневолновых ионосферных радиолиний
Authors: А.У. Жильцов 
Published: November 2024

Приводятся результаты исследований свойств ионосферных сигналов при приёме на СВ радиолиниях с подстилающей поверхностью различной удельной проводимости. Даны рекомендации разработчикам и службам СВ сетей по учёту свойств подстилающих поверхностей. Ключевые слова: средние волны, ионосфера, радиосвязь, радиовещание.
The article contains the results of investigations of ionospheric MF signals at radio lines with various specific earth conductivity. There are recommendations to the specialists of MF services for taking into account the properties of underlying surfaces.