bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dust properties of double-tailed active asteroid (6478) Gault
Authors: Moreno F. , Jehin E. , Licandro J. , Ferrais M. , Moulane Y. , Pozuelos F. J. , Manfroid J. , Devogèle M. , Benkhaldoun Z. , Moskovitz N. , Popescu M. , Serra-Ricart M. , Cabrera-Lavers A. , Monelli M. 
Published: April 2019

Context. Asteroid (6478) Gault was discovered to exhibit a comet-like tail in observations from December 2018, becoming a new member of the so-called active asteroid population in the main asteroid belt.
Aims. We seek to investigate the grain properties of the dust ejected from asteroid (6478) Gault and to give insight into the activity mechanism(s).
Methods. We use a Monte Carlo dust tail brightness code to retrieve the dates of dust ejection, the physical properties of the grains, and the total dust mass losses during each event. The code takes into account the brightness contribution of the asteroid itself. The model is applied to a large data set of images spanning the period from 2019 January 11 to 2019 March 13. In addition, we carried out both short- and long-term photometric measurements of the asteroid.
Results. It is shown that, to date, asteroid (6478) Gault has experienced two episodes of impulsive dust ejection, which took place around 2018 November 5 and 2019 January 2. These two episodes released at least 1.4 × 107 kg and 1.6 × 106 kg of dust, respectively, at escape speeds. The size distribution, consisting of particles in the 1 μm–1 cm radius range, follows a broken power law with bending points near 15 μm and 870 μm. On the other hand, the photometric series indicate a nearly constant magnitude over several 5–7.3 h periods, which is a possible effect of the masking of a rotational light curve by the dust.
Conclusions. The dust particles forming Gault’s tails were released from the asteroid at escape speeds, but the specific ejection mechanism is unclear until photometry of the dust-free asteroid are conducted to assess whether this was related to rotational disruption or to other possible causes.
Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017
Authors: Katon Jodie , Zephyrin Laurie , Meoli Anne , Hulugalle Avanthi , Bosch Jeane , Callegari Lisa , Galvan Ileana , Gray Kristen , Haeger Kristin , Hoffmire Claire , Levis Silvina , Ma Erica , Mccabe Jennifer , Nillni Yael , Pineles Suzanne , Reddy Shivani , Savitz David , Shaw Jonathan , Patton Elizabeth 
Published: April 2019

AbstractThe literature on the reproductive health and healthcare of women Veterans has increased dramatically, though there are important gaps. This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. We excluded studies that were not original research, only included active-duty women, or had few women Veterans in their sample. Manuscripts were reviewed using a standardized abstraction form. We identified 52 manuscripts. Nearly half (48%) of the new manuscripts addressed contraception and preconception care (n = 15) or pregnancy (n = 10). The pregnancy and family planning literature showed that (1) contraceptive use and unintended pregnancy among women Veterans using VA healthcare is similar to that of the general population; (2) demand for VA maternity care is increasing; and (3) women Veterans using VA maternity care are a high-risk population for adverse pregnancy outcomes. A recurrent finding across topics was that history of lifetime sexual assault and mental health conditions were highly prevalent among women Veterans and associated with a wide variety of adverse reproductive health outcomes across the life course. The literature on women Veterans' reproductive health is rapidly expanding, but remains largely observational. Knowledge gaps persist in the areas of sexually transmitted infections, infertility, and menopause.
Common and Uncommon Variations of Pulmonary Venous Drainage in Patients Undergoing Thoracoscopic Lobectomy
Authors: Amore Dario , Casazza Dino , Imitazione Pasquale , Curcio Carlo 
Published: April 2019

Abstract
Background Variations in pulmonary venous anatomy should not be undermined by thoracic surgeons during procedures which involve the pulmonary veins.
Methods We have identified vascular anomalies in 25 of 346 patients undergoing video-assisted thoracoscopic surgery lobectomy at our Thoracic Surgery Unit, between December 2016 and November 2018.
Results Some vascular anomalies described have not been reported in recent literature and include right V7 draining into the middle lobe pulmonary vein, accessory right V6 behind the bronchus intermedius, two V6 from the apical segment of left lower lobe, two V6 from the apical segment of right lower lobe, and one of them draining into the superior pulmonary vein.
Conclusion Thoracic surgeons should be aware of this type of anomalies because failure in the preoperative or intraoperative identification of the pulmonary venous variations may lead to serious complications.
Management of Buerger's Disease in Endovascular Era
Authors: Ghoneim Baker M. , Karmota Ahmed G. , Abuhadema Ahmed M. , Shaker Ahmed A. , Abdelmawla Hany M. , Nasser Mahmoud M. , Elmahdy Hossam Y. , Mostafa Hesham A. , Khairy Hussein M. 
Published: April 2019

AbstractThis study was aimed to report data on the feasibility, safety, and effectiveness of endovascular procedures in a thromboangiitis obliterans diagnosed patients presenting with critical limb ischemia (CLI). Prospective study conducted on patients affected by Buerger's disease who presented to our center along 2 years. Clinical, radiological, and patient-based outcomes were recorded at 3, 6, and 12 months after the intervention. Total 39 patients were included in the study. Fifteen (38.5%) patients underwent percutaneous transluminal angioplasty, another 15 patients (38.5%) underwent follow-up on medical treatment, there are four other patients (10.3%) underwent surgical bypass, and five (12.8%) patients underwent lumbar sympathectomy. The 12 months' outcome showed 66.7% technical success in endovascular group with 46.7% patency rate (p-value = 0.06), 86.7% limb salvage rate (LSR; p-value < 0.04), and 66.7% clinical improvement (p-value = 0.005). The endovascular management of Buerger's disease is feasible, save, and effective with high rate of LSR and clinical improvement.
Oxygen Saturation and Perfusion Index-Based Enhanced Critical Congenital Heart Disease Screening
Authors: Siefkes Heather , Kair Laura , Tancredi Daniel J. , Vasquez Brian , Garcia Lorena , Bedford-Mu Christa , Lakshminrusimha Satyan 
Published: April 2019

Objective To determine if addition of perfusion index (PIx) to oxygen saturation (SpO2) screening improves detection of critical congenital heart disease (CCHD) with systemic outflow obstruction.
Study Design We determined screening thresholds for PIx and applied these to a cohort of newborns with and without congenital heart disease (CHD).
Results A total of 123 normal and 21 CHD newborns (including five with critical systemic outflow obstruction) were enrolled. Four of these five critical systemic obstruction subjects passed SpO2-based screen. Four out of these five subjects failed PIx-based screen. The sensitivity for detection of systemic obstruction CCHD when compared with healthy infants increased from 20% (95% confidence interval [CI]: 1–72%) with SpO2 screening alone to 80% (95% CI: 28–100%) with combined SpO2-PIx screen. However, 2.44% of normal infants failed PIx screen.
Conclusion Addition of PIx to SpO2 screening may detect additional cases of CCHD and further research is necessary to come up with optimal screening thresholds.
Outcome of a Modified Perceval Implantation Technique
Authors: Zhigalov Konstantin , Mashhour Ahmed , Mkalaluh Sabreen , Szczechowicz Marcin , Easo Jerry , Eichstaedt Harald C. , Weymann Alexander 
Published: April 2019

Abstract
Background In our institution, we developed a modification of the standard implantation technique of the Perceval sutureless aortic prosthesis (LivaNova, London, United Kingdom) that involves the usage of snuggers for the guiding sutures during valve deployment. The technique has been described elsewhere. In this article, we present the results of our initial case series comprising 128 consecutive patients.
Methods From September 2016 to June 2018, 128 patients received a sutureless Perceval prosthesis (mean age 72.2 ± 8.5 years, 66 males). The data of the patients were prospectively collected in our general database and retrospectively analyzed using the SPSS software version 25 (IBM SPSS Inc., Chicago, Illinois, United States). Primary end points were primary implantation success and 30-day mortality. All patients underwent transthoracic echocardiography on discharge.
Results Our cohort consisted of real-world scenario patients with infective endocarditis, bicuspid aortic valves and one patient with left ventricular assist device. However, we had 100% primary implantation success with no need for valve explantation or paravalvular leaks. All-cause 30-day mortality was 2.3% (3 patients) with no cardiac deaths. Two patients (1.6%) had a permanent neurological deficit, three patients (2.3%) had new-onset renal dialysis, and four patients (3.1%) needed a permanent pacemaker postoperatively.
Conclusion To our knowledge, this is the first case series to report on a modified implantation technique of the Perceval prosthesis. The Perceval valve prosthesis produces excellent outcome in most pathologies, so that current contraindications should be revised.
Labordiagnostik bei Diabetes mellitus
Authors: Hörber Sebastian , Schleicher Erwin , Peter Andreas 
Published: April 2019

AbstractLaboratory parameters are essential for diagnosis, prognosis and therapy control of diabetes mellitus. Diabetes-specific parameters including glucose, glycated hemoglobin (HbA1c), C-peptide and autoantibodies against beta cell epitopes as well as parameters of lipid metabolism and renal function should be taken into account. The precise and reliable determination of these parameters in accordance with the guidelines of the German Federal Medical Council for the determination of laboratory diagnostics is fundamental for the correct classification and evaluation of the measurement results. For this, important pre-analytical and analytical limitations must be considered.
Metal-organic framework structures: adsorbents for natural gas storage
Authors: Tsivadze Aslan Yu. , Aksyutin Oleg E. , Ishkov Alexander G. , Knyazeva Marina K. , Solovtsova Olga V. , Men’shchikov Ilya E. , Fomkin Anatoly A. , Shkolin Andrey V. , Khozina Elena V. , Grachev Vladimir A. 
Published: April 2019

Natural gas (methane) forms an essential part of modern power supply. However, natural gas storage and transportation are associated with fire and explosion hazard, which restricts extensive application of natural gas as a fuel. The adsorption technique is among the most promising and safe ways for natural gas storage and transportation, which allows a significant increase in the methane density up to values characteristic of liquids as a result of physical adsorption in microporous adsorbents at moderate pressures. The review considers adsorption systems for natural gas (methane) storage based on metal-organic frameworks, which possess high characteristic energy of adsorption and a regular nanoporous structure with high pore volumes and specific surface areas. The possibility of controlling the porous structure and physicochemical behaviour of metal-organic frameworks during their synthesis and functionalization is analyzed, including the fabrication of composites and shaping, which may enhance their performance in the adsorption storage and transportation of natural gas.The bibliography includes 315 references.
Comparing signals of natural selection between three Indigenous North American populations
Authors: Reynolds Austin W. , Mata-Míguez Jaime , Miró-Herrans Aida , Briggs-Cloud Marcus , Sylestine Ana , Barajas-Olmos Francisco , Garcia-Ortiz Humberto , Rzhetskaya Margarita , Orozco Lorena , Raff Jennifer A. , Hayes M. Geoffrey , Bolnick Deborah A. 
Published: April 2019

Significance
Recent studies have shown that humans have adapted to many different environments around the world. However, few studies have centered on Indigenous groups in the Americas. We present a comparative analysis of genetic adaptations in humans across North America using genome-wide scans for signals of natural selection in three populations inhabiting vastly different environments. We find evidence for adaptation to cold and high latitudes in an Alaskan population, whereas infectious disease was a strong selective pressure in the southeastern United States and central Mexico. Because there are few shared signals of selection between populations, these sweeps likely occurred after population differentiation in the Americas. This study fills an important gap in our knowledge of genetic adaptations in humans.
Effectiveness of homologous Thai letterforms presented in parafoveal vision
Authors: Punsongserm Rachapoom , Sunaga Shoji , Ihara Hisayasu 
Published: April 2019

Abstract
Design approaches to improve Thai font legibility by clarifying idealistic key features using a blur simulation
method have been proposed. Specifically, the jutting out of the tail of characters and inclusion of a loop-with-serrated-line,
together with sufficient character width, have been found to improve legibility. In the current study, a set of four homologous
characters was presented to the parafoveal region with a short-exposure methodology to display the characters with low visual
acuity. Overall, the results revealed that most of the chosen idealistic key features enhanced the legibility of characters
presented in parafoveal vision. However, the detailed results revealed variation in the amount of confusion between letter pairs
for each tested character. These findings suggest the need for several practical improvements by modifying the specific features
of each letter. Although the results of the short-exposure and blur simulation approaches differed at times, the findings of both
studies suggest possibilities for developing optimal letterforms using a combination of both methodologies.
Developing tools to support patients and healthcare providers when in conversation about obesity
Authors: Noël Guillermina , Luig Thea , Heatherington Melanie , Campbell-Scherer Denise 
Published: April 2019

Abstract
People living with obesity suffer from multiple health issues, including diabetes and mental health problems.
Misinformation about the complex nature of this condition greatly affects the way one manages obesity. This results in unrealistic
expectations by both healthcare providers and patients. Effective obesity management must be individually tailored for each
patient. The objective of this project was to improve four communication tools by co-designing them with patients. A co-design
approach was used to improve the efficacy and applicability of the tools through a working collaboration between patients, care
providers, and researchers. While most articles describe processes to create shared-decision making (SDM) tools which compare
alternative diagnosis and treatment options, few papers describe models to create SDM tools which go beyond showing benefits and
risks. In this paper, we describe our process and approach to the re-design of four of the 5As obesity tools. We hope this study
provides a valuable model for other teams.
Fermented product of rice with Lactobacillus kefiranofaciens induces anti-aging effects and heat stress tolerance in nematodes via DAF-16
Authors: Sugawara Takaya , Furuhashi Tsubasa , Shibata Kenji , Abe Masayuki , Kikuchi Keita , Arai Masato , Sakamoto Kazuichi 
Published: April 2019

ABSTRACT
Rice kefiran is superior in functionality, has high concentration of mucilaginous polysaccharide, and low lipid content, compared to conventional kefiran. However, reports on its physiological functionality, especially studies on life expectancy and aging, in model organisms are rare. In this study, nematodes were used as model organisms that were fed rice kefiran, along with Escherichia coli OP50, as a result of which, the lifespan of nematodes was extended and age-related retardation of mobility was suppressed. It also increased the heat stress resistance in nematodes. Experiments using daf-16 deletion mutant revealed that rice kefiran functions via DAF-16. Thus, this study revealed the longevity, anti-aging and heat stress tolerance effects of rice kefiran in nematodes.
Fluid surface coatings for solid-state nanopores: comparison of phospholipid bilayers and archaea-inspired lipid monolayers
Authors: Eggenberger Olivia M , Leriche Geoffray , Koyanagi Takaoki , Ying Cuifeng , Houghtaling Jared , Schroeder Thomas B H , Yang Jerry , Li Jiali , Hall Adam , Mayer Michael 
Published: April 2019

Abstract
In the context of sensing and characterizing single proteins with synthetic nanopores, lipid bilayer coatings provide at least four benefits: first, they minimize unwanted protein adhesion to the pore walls by exposing a zwitterionic, fluid surface. Second, they can slow down protein translocation and rotation by the opportunity to tether proteins with a lipid anchor to the fluid bilayer coating. Third, they provide the possibility to impart analyte specificity by including lipid anchors with a specific receptor or ligand in the coating. Fourth, they offer a method for tuning nanopore diameters by choice of the length of the lipid’s acyl chains. The work presented here compares four properties of various lipid compositions with regard to their suitability as nanopore coatings for protein sensing experiments: (1) electrical noise during current recordings through solid-state nanopores before and after lipid coating, (2) long-term stability of the recorded current baseline and, by inference, of the coating, (3) viscosity of the coating as quantified by the lateral diffusion coefficient of lipids in the coating, and (4) the success rate of generating a suitable coating for quantitative nanopore-based resistive pulse recordings. We surveyed lipid coatings prepared from bolaamphiphilic, monolayer-forming lipids inspired by extremophile archaea and compared them to typical bilayer-forming phosphatidylcholine lipids containing various fractions of curvature-inducing lipids or cholesterol. We found that coatings from archaea-inspired lipids provide several advantages compared to conventional phospholipids; the stable, low noise baseline qualities and high viscosity make these membranes especially suitable for analysis that estimates physical protein parameters such as the net charge of proteins as they enable translocation events with sufficiently long duration to time-resolve dwell time distributions completely. The work presented here reveals that the ease or difficulty of coating a nanopore with lipid membranes did not depend significantly on the composition of the lipid mixture, but rather on the geometry and surface chemistry of the nanopore in the solid state substrate. In particular, annealing substrates containing the nanopore increased the success rate of generating stable lipid coatings.
ClinOmicsTrailbc: a visual analytics tool for breast cancer treatment stratification
Authors: Schneider Lara , Kehl Tim , Thedinga Kristina , Grammes Nadja Liddy , Backes Christina , Mohr Christopher , Schubert Benjamin , Lenhof Kerstin , Gerstner Nico , Hartkopf Andreas Daniel , Wallwiener Markus , Kohlbacher Oliver , Keller Andreas , Meese Eckart , Graf Norbert , Lenhof Hans-Peter 
Published: April 2019

AbstractMotivationBreast cancer is the second leading cause of cancer death among women. Tumors, even of the same histopathological subtype, exhibit a high genotypic diversity that impedes therapy stratification and that hence must be accounted for in the treatment decision-making process.ResultsHere, we present ClinOmicsTrailbc, a comprehensive visual analytics tool for breast cancer decision support that provides a holistic assessment of standard-of-care targeted drugs, candidates for drug repositioning and immunotherapeutic approaches. To this end, our tool analyzes and visualizes clinical markers and (epi-)genomics and transcriptomics datasets to identify and evaluate the tumor’s main driver mutations, the tumor mutational burden, activity patterns of core cancer-relevant pathways, drug-specific biomarkers, the status of molecular drug targets and pharmacogenomic influences. In order to demonstrate ClinOmicsTrailbc’s rich functionality, we present three case studies highlighting various ways in which ClinOmicsTrailbc can support breast cancer precision medicine. ClinOmicsTrailbc is a powerful integrated visual analytics tool for breast cancer research in general and for therapy stratification in particular, assisting oncologists to find the best possible treatment options for their breast cancer patients based on actionable, evidence-based results.Availability and implementationClinOmicsTrailbc can be freely accessed at https://clinomicstrail.bioinf.uni-sb.de.Supplementary informationSupplementary data are available at Bioinformatics online.
Evidence for Similar Prefrontal Structural and Functional Alterations in Male and Female Rats Following Chronic Stress or Glucocorticoid Exposure
Authors: Anderson Rachel M , Johnson Shane B , Lingg Ryan T , Hinz Dalton C , Romig-Martin Sara A , Radley Jason J 
Published: April 2019

Abstract
Previous work of ours and others has documented regressive changes in neuronal architecture and function in the medial prefrontal cortex (mPFC) of male rats following chronic stress. As recent focus has shifted toward understanding whether chronic stress effects on mPFC are sexually dimorphic, here we undertake a comprehensive analysis to address this issue. First, we show that chronic variable stress (14-day daily exposure to different challenges) resulted in a comparable degree of adrenocortical hyperactivity, working memory impairment, and dendritic spine loss in mPFC pyramidal neurons in both sexes. Next, exposure of female rats to 21-day regimen of corticosterone resulted in a similar pattern of mPFC dendritic spine attrition and increase in spine volume. Finally, we examined the effects of another widely used regimen, chronic restraint stress (CRS, 21-day of daily 6-h restraint), on dendritic spine changes in mPFC in both sexes. CRS resulted in response decrements in adrenocortical output (habituation), and induced a pattern of consistent, but less widespread, dendritic spine loss similar to the foregoing challenges. Our data suggest that chronic stress or glucocorticoid exposure induces a relatively undifferentiated pattern of structural and functional alterations in mPFC in both males and females.
Mosaic Tetrasomy 9p Associated With Inflammatory Bowel Disease
Authors: Sifuentes-Dominguez Luis , Starokadomskyy Petro , Welch Jacob , Gurram Bhaskar , Park Jason Y , Koduru Prasad , Burstein Ezra 
Published: April 2019

Abstract
The genetic basis of inflammatory bowel disease remains to be elucidated completely. Here we report on a patient with inflammatory bowel disease who has mosaic tetrasomy of the short arm of chromosome 9, a genomic region that harbours the type I interferon gene cluster. We show that increased interferon activation is present in peripheral blood and intestinal tissue from this patient, similar to previous reports of autoinflammatory organ damage driven by interferon activation in other patients with this chromosomal abnormality. To our knowledge, this is the first case of tetrasomy 9p-associated interferonopathy driving intestinal inflammation and highlights the role that type-I interferon pathways can play in the pathogenesis of intestinal inflammation.