bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical research about the improved PVP method in treatment of acute osteoporotic vertebral compression fractures
Authors: Zhang Yao , Song JiPeng , Hou Yu , Zhang GenAi , Ding LiXiang 
Published: August 2019

Objective: The traditional percutaneous vertebroplasty (PVP) could induce massive radiation and side injuries to the tissues around the fractured centrum. This study was designed to reduce the radiation and damage and improve the treatment efficiency of PVP. Methods: Forty four patients who diagnosed to be acute osteoporotic single vertebral compression fractures were collected and randomly divided into traditional group and improved group, and these two groups were separately treated by the traditional and improved PVP which assisted by the preoperative digital design. The treatment outcome between these two groups was compared and analyzed by Students’ t test and χ 2 test. Results: Compared with the traditional PVP, the improved PVP could significantly reduce the X-ray fluoroscopy times for determining puncture point (14.41 ± 4.00 vs. 6.82 ± 2.15, p < 0.001) and puncture route (22.73 ± 3.89 vs. 13.36 ± 3.39, p < 0.001), the X-ray fluoroscopy times during the operation (76.59 ± 12.4 vs. 34.82 ± 6.74, p < 0.001), operation duration (28.64 ± 7.43 min vs. 15.23 ± 4.4 min, p < 0.001), and total radiological dose (588.85 ± 53.86 cGycm2 vs. 276.5 ± 58.17 cGycm2, p < 0.001). The improved PVP could also significantly decrease the visual analog score at intra-operation (7.68 ± 0.78 vs. 4.50 ± 0.67, p < 0.001) and 1 day after the operation (2.45 ± 0.51 vs. 2.16 ± 0.36, p < 0.05). Besides, the improved PVP could not significantly affect the Oswestry disability index after operation ( p > 0.05). Conclusion: The improved PVP operation could significantly reduce the total radiological dose and X-ray fluoroscopy times, protect the patients and medical staff, and reduce the pain caused by the operation. Trial registration: This trial was registered in China clinical trial registration center and the registration number was ChiCTR-INR-17011557.
High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells
Authors: Takihara Yuji , Nakamura-Ishizu Ayako , Tan Darren Qiancheng , Fukuda Masahiro , Matsumura Takayoshi , Endoh Mitsuhiro , Arima Yuichiro , Chin Desmond Wai Loon , Umemoto Terumasa , Hashimoto Michihiro , Mizuno Hidenobu , Suda Toshio 
Published: August 2019

Key Points
HSCs can be separated based on high or low mitochondrial mass. Higher mitochondrial mass is associated with quiescence and greater reconstitution capacity of HSCs.
Multiparametric and multiregional diffusion features help predict molecule information, grade and survival in lower-grade gliomas: a feasibility study
Authors: Lin Hai , Xu Yanwen , Chen Lei , Na Peng , Li Weiping 
Published: August 2019

Objective: This study was to investigate the relationship of diffusion features with molecule information, and then predict grade and survival in lower-grade gliomas. Methods: 65 patients with primary lower-grade gliomas (WHO Grade II & III) who underwent conventional MRI and diffusion tensor imaging were retrospectively studied. The tumor region was automatically segmented into contrast-enhancing tumor, non-enhancing tumor, edematous and necrotic volumes. Diffusion features, including fractional anisotropy (FA), axial diffusivity, radial diffusivity and apparent diffusion coefficient (ADC), were extracted from each volume using histogram analysis. To estimate molecule biomarkers and predict clinical characteristics of grade and survival, support vector machine, generalized linear model, logistic regression and Cox regression were performed on the related features. Results: The diffusion features in non-enhancing tumor volume showed differences between isocitrate dehydrogenase mutant and wild-type gliomas. And the mean accuracy of support vector machine classifiers was 0.79. Ki-67 labeling index was correlated with these features, which were combined to significantly estimate Ki-67 expression level (r = 0.657, p < 0.001). These features also showed differences between Grade II and III gliomas. A combination of them for grade classification resulted in an area under the curve of 0.914 (0.857–0.971). Mean FA and fifth percentile of ADC were independently associated with overall survival, with lower FA and higher ADC showing better survival outcome. Conclusion: In lower-grade gliomas, multiparametric and multiregional diffusion features could help predict molecule information, histological grade and survival. Advances in knowledge: The multi parametric diffusion features in non-enhancing tumor were associated with molecule information, grade and survival in lower-grade gliomas.
A retrospective analysis of the treatment results for advanced synchronous head and neck and esophageal cancer
Authors: Fan Kang-Hsing , Chao Yin-Kai , Chang Joseph Tung-Chieh , Tsang Ng-Ming , Liao Chun-Ta , Chang Kai-Ping , Lin Chien-Yu , Wang Hong-Ming , Hsu Cheng-Lung , Huang Shiang-Fu 
Published: August 2019

Objective: The treatments for synchronous head and neck cancer (HNC) and esophageal cancer (ESC) are toxic and difficult to employ. The aim of this study was to identify the feasibility of a protracted, less toxic treatment course and prognostic factor of synchronous HNC and ESC. Methods: Cancer registry data from 2004 to 2012 were reviewed. The inclusion criteria were two cancer diagnoses within 30 days, and Stage III/IV HNC or Stage II–IV ESC that chemoradiation therapy was indicated. Evident metastasis, Eastern Cooperative Oncology Group performance score >2, a history of prior cancer, or palliative treatment were excluded. Survival rates and patient and treatment characteristics were analyzed. Results: There were 51 eligible cases. The 2 year overall survival rate was 25.1%. Univariate analysis found that anemia, larynx/hypopharynx HNC, and no esophagectomy correlated with poor overall survival. Multivariate analysis demonstrated that anemia and no esophagectomy were independent poor prognostic factors. The 2 year progression-free survival rate was 14.8%. Univariate analysis found only no esophagectomy correlated with poor progression-free survival. Conclusion: The outcomes are poor for patients with advanced synchronous HNC and ESC. Radiotherapy with a split or protracted course does not result in inferior treatment result and can be considered when the aim is to avoid adverse events. Esophagectomy correlated with good prognosis and should be performed for patients if possible. Advances in knowledge: The treatment results of synchronous HNC and ESC is poor. A protracted chemoradiation course for synchronous HNC and ESC did not result in inferior survival and should be applied to patients with a poor prognosis. Esophagectomy correlates with good outcomes and should be encouraged if the patient has a good prognosis.
Assessment of relationship between extracranial and intracranial carotid calcifications—a retrospective cone beam computed tomography study
Authors: Mutalik Sunil , Tadinada Aditya 
Published: August 2019

Objectives: Cone beam CT scans in current day dental practice are highly collimated yet involve areas along the course of the extracranial carotid artery. Detecting an extracranial carotid calcification on small volume scans leaves the dentist with two questions: whether the patient is likely to have intracranial carotid calcifications and whether the patient warrants further medical attention. This study aimed to assess the presence of intracranial carotid artery calcifications (ICAC) in the presence of extracranial carotid artery calcifications (ECAC). Methods: 450 CBCT scans were retrospectively evaluated for ECAC and ICAC. Erby et al’s classification was modified to classify calcifications as mild, moderate, and severe. The presence of ICAC when ECAC were present was evaluated in all three orthogonal planes. The risk of ICAC in the presence of ECAC was calculated as odds ratio and the association between the two was calculated using a χ2 test. Results: The odds ratio for bilateral ICAC in the presence of bilateral ECAC was 15.09. The odds ratio for left ICAC/right ICAC in the presence of left/ right ECAC was 0.833 and 2.564, respectively. The number and severity of calcifications increased with age. The χ2 test showed that there was a strong association (p < 0.001) between bilateral ECAC with bilateral ICAC. Conclusions: The results of this group of patients showed that there is an increased presence of ICAC in the presence of ECAC.
Factors affecting the outcome of hospitalization among liver cirrhosis patients
Authors: Mahmud Yasir , Irfan Muhamamd , Khan Rana Muhammad Suhail , Rafiqa Qamar , Nadeem Muhammad Arif , Mohsin Aftab 
Published: August 2019

Objectives: To determine the factors affecting the outcome of hospitalization in patients suffering liver cirrhosis hospitalized to tertiary care hospital, Gujranwala, Pakistan.
Methods: After informed consent, the data of liver cirrhosis patients with age >12 years hospitalized from June 2016 to May 2017 was collected by purposive sampling. The outcome of the hospitalization in term of ‘death’ and ‘no death’ was noted. Statistical analysis was done using SPSS version 25. Bivariate analysis as well binary logistic regression was performed to ascertain the effect of different predictors like gender, age, history of diabetes mellitus, etiology of cirrhosis, presence of hepatic encephalopathy at presentation, presence of upper GI bleed, and tracheobronchial aspiration on the likelihood that death would be the outcome in liver cirrhosis patients.
Results: Amongst total of 1304 patients, 15.7% died during hospitalization. The mean age of those who died was 58.08 + 14.49 years. Bivariate analysis suggested that mortality was significantly higher in group of patients who had hepatic encephalopathy at presentation (p<0.01), no upper gi bleed (p<0.01), and who got tracheobronchial aspiration during hospitalization (p<0.01). It did not differ significantly in male/female gender (p=0.504), diabetic/non-diabetic groups (p=0.652), with viral/non-viral etiology of cirrhosis (p=0.918). Binary logistic regression revealed that patients who had tracheobronchial aspiration were 12.392 times more likely to die than who had no tracheobronchial aspiration. Similarly, patients who presented in hepatic encephalopathy were 7.862 times more likely to die than who presented without hepatic encephalopathy.
Conclusion: The inpatient mortality rate amongst cirrhotic patients was high. Age, gender, history of diabetes, viral etiology of cirrhosis did not significantly contribute in the mortality of these patients. The patients who presented in hepatic encephalopathy, and who suffered tracheobronchial aspiration during hospitalization were more likely to die. Excellence in hepatic encephalopathy management and prevention from aspiration can effectively reduce the mortality rate of cirrhotic patients in our hospitals.
doi: https://doi.org/10.12669/pjms.35.5.884
How to cite this:Irfan M, Mahmud Y, Khan RMS, Rafiq Q, Nadeem MA, Mohsin A. Factors affecting the outcome of hospitalization among liver cirrhosis patients. Pak J Med Sci. 2019;35(5):1382-1386. doi: https://doi.org/10.12669/pjms.35.5.884
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Adverse reactions of dimethyl sulfoxide in humans: a systematic review
Authors: Kollerup Madsen Bennedikte , Hilscher Maria , Zetner Dennis , Rosenberg Jacob 
Published: August 2019

Background: Dimethyl sulfoxide (DMSO) has been used for medical treatment and as a pharmacological agent in humans since the 1960s. Today, DMSO is used mostly for cryopreservation of stem cells, treatment of interstitial cystitis, and as a penetrating vehicle for various drugs. Many adverse reactions have been described in relation to the use of DMSO, but to our knowledge, no overview of the existing literature has been made. Our aim was to conduct a systematic review describing the adverse reactions observed in humans in relation to the use of DMSO. Methods: This systematic review was reported according to the PRISMA-harms (Preferred Reporting Items for Systematic reviews and Meta-Analysis) guidelines. The primary outcome was any adverse reactions occurring in humans in relation to the use of DMSO. We included all original studies that reported adverse events due to the administration of DMSO, and that had a population of five or more. Results: We included a total of 109 studies. Gastrointestinal and skin reactions were the commonest reported adverse reactions to DMSO. Most reactions were transient without need for intervention. A relationship between the dose of DMSO given and the occurrence of adverse reactions was seen. Conclusions: DMSO may cause a variety of adverse reactions that are mostly transient and mild. The dose of DMSO plays an important role in the occurrence of adverse reactions. DMSO seems to be safe to use in small doses. Registration: PROSPERO CRD42018096117.
A Study of Implicature in Daredevil Web Series Movie
Authors: Fauzia Fauzia , Prakoso Isnaini Jalu Rakhmat 
Published: August 2019

This study is aimed to identify the implicature and their maxim violation and find out how the violating maxims occur in the movie. The study is conducted by using the qualitative method. The research object of this study is about implicature and the violation of the maxim. The subject of this study is a web series movie script entitled Daredevil, the scripts are taken from season 1 episode 1 until 3. To collect the data, the writer uses note taking technique. The writer uses pragmatic referential method (metode padan pragmatis) to analyze the data. The result shows 25 implicatures in Daredevil web series movie that occur because of its violation of the maxim. There are 20% implicature by violating the maxim of quantity, 36% implicature by violating the maxim of quality, 26% implicature by violating the maxim of relation, 18% implicature by violating the maxim of manner. By violating the maxim, the characters produce some implied meanings which can be used to misleading the hearer. The implied meaning of the utterances refers to an expression of agreement, denial, refusal, acceptance and indirect sentence, it depends on how the character uses the implicature. Key words: Pragmatics, Context, Cooperative Principle, Implicature, Violating Maxim
The Use of Phonetically Reduced Modals in Present-day English: A Corpus-Based Analysis
Authors: Oktavianti Ikmi Nur 
Published: August 2019

This paper examines the usage frequency of phonetically reduced modals (i.e. gonna, wanna, gotta) in Present-day English. It is assumed that in distinct sociolinguistic and discourse contexts, the use of reduced modals is dynamic. To collect the data, there are two corpora used in this study, Corpus of Contemporary American English and Global Web-Based English as the representatives of Present-day English. The analysis focuses on usage frequency of phonetically reduced modals over period of time, in different regions, different medium of language use, and different text types. The frequencies were further interpreted based on sociolinguistics and text genre perspective to reveal the factors triggering the dynamic of use. The results of this study show the use of reduced modals is dramatically escalating in the last decades. According to regional observation, the use of reduced modals is more frequent in the United States than in other English-speaking countries. In relation to medium of language use, reduced modals are more commonly used in spoken language than in written language. As for text type, the usage frequency of reduced modal in fiction texts is the highest compared to academic texts and news texts. Academic texts seem to avoid these linguistic units since this sort of text must obey the use of standard language in which reduced forms are less standard and more colloquial. This phonetic reduction is plausible to occur since language system and language use apply economy principle. The use of phonetically reduced modals, however, varies in different context, varies in different context, influenced by colloquialization: the more colloquial the context is, the more frequent they are. In general, language use is phonetically simplified and sociolinguistically colloquialized.
Interventions in infected venous leg ulceration in clinical practice
Authors: Brown Annemarie 
Published: August 2019

Annemarie Brown explores the vital role practice nurses play in caring for patients with infected venous leg ulcers. In particular, recognising signs and symptoms, management, and the threat of antimicrobial resistance will be discussed This article aims to inform practice nurses of the management of infection in venous leg ulcers which they may encounter in clinical practice. It outlines the infection continuum, how to recognise the signs and symptoms of an increasing bacterial burden and how this can be effectively managed to prevent the patient developing a systemic infection. In view of Government policies to reduce the inappropriate use of systemic antibiotics, guidance on using topical antiseptics and antimicrobials is discussed, together with information on the various products available. The signs of sepsis are discussed to ensure that readers are familiar with this life-threatening condition.
AMR: effective infection prevention and control measures
Authors: Fleming Naomi 
Published: August 2019

Antimicrobial resistance is on the rise. As more infections are becoming resistant to antibiotic treatment, it would benefit practice nurses to be aware of the effective measures they can use to prevent the spread of infection, explains Naomi Fleming When micro-organisms are exposed to an antimicrobial, more susceptible organisms succumb, leaving behind those resistant to the antimicrobial. They can then pass on resistance to their offspring. The use and misuse of antimicrobials has increased the number and types of resistant organisms. As a result, standard treatments become ineffective and infections persist and may spread. Infection prevention and control (IPC) is key to reducing demand for antimicrobial use and reducing the acquisition of antimicrobial resistance. Poor IPC can increase the spread of drug-resistant infections. Interventions such as effective hand hygiene and vaccination have significant potential to limit opportunities for drug-resistant strains to emerge. Effective leadership is vital and nurses are central to promoting IPC, leading on IPC compliance and ensuring uptake of vaccination in primary care.
Vaccination uptake and information for parents
Authors: Sisson Helen 
Published: August 2019

With the growing risk of misinformation on the internet, it is important for practice nurses to be equipped with the most up-to-date knowledge on immunisation. Helen Sisson explains why it is vital for nurses to be aware of vaccination rates in their area to boost uptake The childhood vaccination programme is a fundamental public health intervention that relies on sufficient coverage for its success, yet coverage data demonstrate a decline in uptake across England. An awareness of uptake rates is essential to identify areas of low coverage, and to develop approaches to address them. Vaccine coverage in the childhood programme depends on parental decision-making, and given the vast amount of information available to parents, knowledge of and access to accurate and credible sources is essential.
Building resilience in contemporary nursing practice
Authors: Best Catherine 
Published: August 2019

The nursing profession is being threatened by staff shortages. Catherine Best explains why building resilience from within the profession is vital to safeguarding its future, by keeping newly qualified nurses in the job and preventing emotional ‘burnout’ across disciplines Resilience in nursing has been critiqued and challenged throughout the nursing literature. Trends in nursing have led to many nurses leaving the profession early in their career, often due to the immense pressures that they work under. There are many opinions on how nurses can develop the resilience needed to maintain professional integrity and continue to provide safe and effective care, while attempting to shoulder the considerable impact of political and professional drivers. This not only leaves nurses exhausted but often without hope. By taking collective action, this article argues that nurses may benefit from sharing ideas and learning from others, and in so doing rekindle hope and a belief that things can change.
Exchange nailing versus augmentative plating in the treatment of femoral shaft nonunion after intramedullary nailing: a meta-analysis
Authors: Luo Hua , Su Yongwei , Ding Liang , Xiao Haijun , Wu Ming , Xue Feng 
Published: August 2019

With advances in the treatment of femoral shaft nonunion after intramedullary nailing, the optimal option remains controversial. This study aimed to quantitatively investigate outcomes in a comparison of exchange nailing and augmentative plating for femoral shaft nonunion after intramedullary nailing. The EMBASE, PubMed, Cochrane library and Clinical databases were systematically searched dating from their inception to March 2018. All retrospective controlled and prospective trials evaluating exchange nailing and augmentative plating for the treatment of femoral shaft nonunion after intramedullary nailing were identified. Two investigators extracted all related data independently and we used the review manager software to perform the meta-analysis. Three studies with a total of 232 patients were eligible for data extraction in our study. The meta-analysis indicated that the augmentative plating group had a lower nonunion rate, shorter time to union, less intra-operative blood loss, and shorter operative time than the exchange nailing group. While for the infection rate, there was no significant difference between augmentative plating and exchange nailing group. The available evidence has shown that augmentative plating is superior to exchange nailing for femoral shaft nonunion after intramedullary nailing.Cite this article: EFORT Open Rev 2019;4:513-518. DOI: 10.1302/2058-5241.4.180054
Educational Recommendations on Selected Analytical and Clinical Aspects of Natriuretic Peptides with a Focus on Heart Failure: A Report from the IFCC Committee on Clinical Applications of Cardiac Bio-Markers
Authors: Kavsak Peter A , Lam Carolyn S P , Saenger Amy K , Jaffe Allan S , Collinson Paul , Pulkki Kari , Omland Tobjørn , Lefèvre Guillaume , Body Richard , Ordonez-Llanos Jordi , Apple Fred S 
Published: August 2019

Abstract
The IFCC Committee on Clinical Applications of Cardiac Bio-Markers (C-CB) has directives and initiatives focused on providing evidence-based educational resources to aid and improve understanding around key analytical and clinical aspects of cardiac biomarkers used in clinical practice and the research setting. As a task force, we have previously published position statements and recommendations focused on use and analytical aspects of high-sensitivity cardiac troponin assays. The current educational document is the first from the C-CB highlighting important biochemical, analytical, and clinical aspects as they relate to the natriuretic peptides (NPs), including B-type natriuretic peptide (BNP) and N-terminal pro–B-type natriuretic peptide (NT-proBNP), with a focus on heart failure.