bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of hepatocellular carcinoma progression by methotrexate-modified pH-sensitive sorafenib and schisandrin B micelles
Authors: Yan Yu-hui , Kong Liang , Lu Ying-bo , Li Si-yang , Yan Ai-wen , Song Yue-wen , Huang Zi-han , Zhu Hao-nan 
Published: December 2024

Abstract
Due to the lack of specific symptoms, hepatocellular carcinoma (HCC) is often detected in advanced stages. However, pharmacological systemic therapy, a common clinical treatment for advanced HCC, is prone to serious toxic side effects. To address these issues, we designed a pH-sensitive sorafenib and schisandrin B micelle modified by methotrexate (MTX-SOR/SchB micelles), a nanosystem that combines the advantages of targeted delivery and pH sensitivity, and is capable of improving drug bioavailability and mitigating drug toxic side effects. Firstly, we characterized the physical and chemical properties of micelles, including particle size, Zeta potential, encapsulation efficiency, pH sensitivity and stability. Hepa1-6 cells and fluorescence imaging were used to investigate the targeting ability of MTX-SOR/SchB micelles. Anti-hepa1-6 cell proliferation, invasion, migration, and pro-apoptotic effects were evaluated in vitro. In addition, HCC tumor-bearing mouse and lung metastasis mouse models were established to investigate the anti-HCC ability of MTX-SOR/SchB micelles, and finally their biological safety was evaluated. We found that the particle size of MTX-SOR/SchB micelles was uniformly distributed, could effectively encapsulation of the drug, had low leakage rate, sensitive pH response, and perfect stability. And MTX-SOR/SchB micelles could target HCC cells with high expression of folate receptor in vitro and in vivo. Moreover, MTX-SOR/SchB micelles could inhibit the proliferation, invasion and metastasis of HCC in vitro and in vivo and promote apoptosis. MTX-SOR/SchB micelles also show good biosafety. In conclusion, MTX-SOR/SchB micelles can effectively enhance the therapeutic effect of HCC, reduce systemic toxicity of drugs, which is expected to be used in clinical treatment.
The application of remote monitoring tools in the educational process on the example of the research of the content of water vapor in the atmosphere
Authors: Yelistratova L A , Apostolov A A , Tomchenko O V , Ya Khodorovskyi A , Tymchyshyn M A 
Published: December 2024

Abstract
The paper shows the advantages of using remote satellite monitoring of the Earth in the educational process for the purposes of sustainable development. Using the example of the study of water vapor content in the atmosphere of Ukraine from 2001 to 2022, calculations of two approaches to obtaining, processing, and interpreting remote sensing data are given. The first approach – complicated – consisted of receiving satellite monitoring data and their further processing (transformation, cutting within the given area, interpretation, and conversion) in the Erdas Imagine program directly on a local computer. The second approach – simplified – consisted of the application of the Giovanni NASA online web application, which allows effective use of remote satellite monitoring data on a remote server based on specific requests and configured parameters, with results displayed on the screen in the form of thematic maps and graphs, that is, requiring their processing to a minimum. The discussion provides a comparison of the obtained results of these two proposed approaches (complicated and simplified) and describes their advantages and disadvantages for more efficiently obtaining the results of scientific research.
Below ground carbon stock of mangrove stands of a mining site in Hinatuan Island, Northeastern Mindanao, Philippines
Authors: Benavides R C , Patero J L , Jondonero M A P , Jondonero P K A , Mariano H G , Amparado R F 
Published: December 2024

Abstract
Mangrove ecosystem provides important services such as storing and sequestering large amount of carbon. However, it faces several anthropogenic pressures especially from resource extractive activities that threatened the ecosystem. Hence, huge companies are obliged to make rehabilitation efforts to rehabilitate the mangrove ecosystem that they have caused damage. Our study aims to determine the carbon stock dynamics of a mangrove rehabilitated site which was damaged due to the siltation brought by the nearby mining. We established a study plot in a mangrove rehabilitated site (Lipata) near the mining area and on a nearby natural mangrove forest (cagutsan) as a point of reference. We determine the mean DBH, height and estimated the soil carbon storage capacities. We found out that in both sites of rehabilitated (Lipata) and natural (Cagutsan) mangrove stand the Rhizophora mucronata is the most dominant, both has similar mean dhb of 6 cm and the height is mostly dominated by. The soil C content shows that as the soil gets deeper up to 50-100 cm the higher the soil carbon content. There was no significant variation in terms of the average soil carbon content of the rehabilitated site is 42.63 MgC/Ha and the natural mangrove stand of 53.59 MgC/Ha. Hence the finding supports the effectiveness of the rehabilitation efforts and calls for continuous rehabilitation of damaged mangrove sites in the area.
Improved the municipal wastewater treatment technology in towns and villages
Authors: Tkachenko T V , Haidai O O , Kamenskyh D S , Yevdokymenko V O 
Published: December 2024

Abstract
Traditional biological wastewater treatment systems are unable to completely remove biogenic substances due to the lack of the necessary amount of substrate, the specifics of the technological scheme, and only the involvement of raw sediment and partially excess sludge in the biological process (continued aeration) can solve the specified problem. The use of psychrophilic anaerobic displacement reactors with an expanded layer of sludge (EGSB-reactors) and subsequent stages of biological treatment will allow to achieve of deep purification of wastewater from carbon, nitrogen and phosphorus in purified water and significantly reduce the volume of extracted sediments and their morphology. Therefore, the aim of our work was the development of a method of municipal wastewater treatment using facilities with a lower material capacity, with lower energy consumption for deep biological removal of carbon, nitrogen and phosphorus compounds. Systematic investigations of the technologies, reactor designs, and processes for anaerobic treatment of low-concentration effluents in psychrophilic conditions calculations were carried out at the Kaniv wastewater treatment plant. Based on this, a model-concept of treatment facilities was developed. Design work was completed for the reconstruction of the Kaniv wastewater treatment plant, where two EGSB psychrophilic reactors, converted from the existing two-tier clarifiers, were put into operation.
Application of geoinformation systems in the development of the city’s intelligent transport network
Authors: Ye Pomortseva O , Kobzan S M , Panteleeva N B 
Published: December 2024

Abstract
The purpose of the research in this article is to reveal modern approaches in the development of the intelligent transport city’s networks, as a component of the social infrastructure of the modern city. The research carried out by the authors in this direction is relevant in the field regarding the improvement and attractiveness of a modern, digital city. In particular, the authors in the article examine the so-called “sleeping” districts with multi-story buildings. The authors suggest the creation of a high-speed bus transportation system to improve the services provided by public transport. The article uses the ArcGIS geoinformation system and built a geodatabase. These two components together allow you to visualize results for a visual presentation of information and qualitative analysis. The authors use such proprietary developments in the article that it is possible to model various variants of the transport network. The authors conducted research on the example of Kramatorsk, a city of regional importance in the Donetsk region. The article develops and proposes a sequence of stages in the development of a geodatabase and a transport network of high-speed bus transportation. The further direction of research may be related to the accounting of a large number of factors. The authors carried out the work with the help of the ArcGis geoinformation system and the developed geodatabase with the necessary layers and attribute information. The article develops a system of high-speed bus transportation in the city of Kramatorsk with promising routes. Such development will allow further improvement of the social infrastructure of other cities. The principle of preliminary modeling using the developed geodatabase used by the authors will be effective for solving issues related to social infrastructure, so it can be applied to solve similar problems in any city. Thus, the authors’ intellectual analysis of geostatic models of public transport movement on the territory of the city made it possible to find zones and classify them depending on the pedestrian accessibility to stops and compare them with existing transport routes. With the help of geostatistics methods, the article transforms data from a discrete to a continuous form of representation.
Consideration of multifactorial geomechanical-technological factors in determining the rational parameters for site outgassing technology at the Western Donbas mines (Ukraine)
Authors: Bondarenko V I , Kovalevska I A , Symanovych H A , Salieiev I A , Shyshov M V 
Published: December 2024

Abstract
The paper examines a promising component for the energy sector – development of gas reserves and gas production, taking into account the peculiarities of mining-geological and mining-technical conditions of the Western Donbas deposits (Ukraine). Two components of the solution to this issue are analyzed: the texture and physical-mechanical properties of weakly metamorphosed rocks and the use of high-performance complexes, reuse of extraction drifts with resource-saving technologies for their maintenance. Based on multivariate computational experiments, schemes have been developed to determine parameters for the location of outgassing wells. Three basic methodological provisions based on the conducted analytical research performed by the finite element method have been substantiated. Calculations, which are the basis for the methodology of selecting outgassing well location parameters, have been conducted. Experimental measurements conducted at six extraction sites of two mines confirm that the outgassing coefficient according to the recommended parameters exceeds that corresponding to the existing outgassing well location schemes in mines (the range of relative increase in the outgassing coefficient is from 19 % to 123 %). In addition, a significant influence (up to 35 – 60 %) has been revealed of the coal-overlaying formation texture, the well gradient angle (20 – 30 %), and the drilling step of outgassing wells (30 – 40 %). It has been found that an increase in the longwall face advance velocity improves the gas trapping efficiency by 25 – 40 %, leading to a decrease in the methane flow into adjacent mine workings and substantiates an opportunity to accelerate the longwall face advance.
Methodology of operative setting of mass crystallization parameters of gas hydrate in reservoir systems
Authors: Pedchenko M M , Pedchenko N M , Pedchenko L O 
Published: December 2024

Abstract
In the course of experimental studies, the method of operational setting of the parameters of mass crystallization of gas hydrate in reservoir systems that have not reached a state of equilibrium is substantiated. The technique is implemented by setting the process parameters at the moment of visual identification of the solid phase of the gas hydrate on the interphase surface of the gas bubble or the place of its exit from the liquid. The requirements for the construction of the reactor unit of the laboratory installation for the implementation of this technique are substantiated. A laboratory installation has been developed and implemented. The results of test studies are presented and the features of identification of the solid phase of gas hydrate at the moment of the beginning of its mass crystallization are demonstrated. The proposed method allows you to quickly obtain objective information about the possible behavior of this system in the case of intensive changes in parameters in non-equilibrium conditions.
Strategic approach to sustainable development of railway transport and optimizing the use of empty cars in organizing transportation of dangerous goods
Authors: Strelko O H , Muzykin M I , Nesterenko H I , Bibik S I , Soloviova O S 
Published: December 2024

Abstract
Under present-day conditions in the development of the transport market, organizing the transportation of dangerous goods by rail is an urgent task, considering the specific properties of the impact of dangerous goods on technical devices, human health, and the environment. The number of parameters influencing the safety of the transportation process is quite large, therefore, programs for the safe and sustainable development of railway transport must involve protection from all possible sources of danger. The strategy for sustainable development of railway transport should be based on improving regulatory and technical documentation, developing safe technology for eliminating the consequences of emergencies, developing network computer technologies, and improving vehicles and transportation technology. Since the transportation of dangerous goods represents a significant share of the total transportation of goods, including railway transport, the research outlined in the presented work is aimed at solving some aspects of this strategy, which as a result forms a strategic approach to the sustainable development of railway transport when organizing the transportation of dangerous goods. In this paper, considering modern conditions for the development of railway transport, it is proposed to comprehensively implement the assigned task with a new approach by introducing a system of operational control during the transportation and temporary storage of dangerous goods and applying the developed method for the optimal distribution of empty cars among cargo checkpoints in the organization of the transportation process.
An integrated approach to forecasting and managing emergency situations in the working faces of coal mines: a set of technical, organizational and measures to ensure occupational safety with subsequent assessment of potential consequences
Authors: Yevtushenko N S , Tverdokhliebova N Y 
Published: December 2024

Abstract
The need for worker safety in the coal mining industry is critical because workers in this industry are exposed to a number of hazards and risks. Accidents occurring in the technogenic sphere of the coal industry cause significant damage to the state economy. Loss of production, repair and restoration of infrastructure, compensation to victims, damage to the environment require significant financial outlays. Therefore, it is important to take all necessary measures to prevent accidents and minimize their consequences. The purpose of the work is to identify the zones of manifestation of hazards and forecasting the risks of emergencies, as well as to develop a set of technical and organizational measures to prevent accidents and incidents during production work. The importance of the study lies in the development of recommendations for identifying the main risk factors in coal mines cleaning faces, the creation of a set of technical and organizational measures to quantify the risk of emergencies, as well as improving the level of safety of the main working processes in planning safe mining operations. Ensuring safety of coal industry workers is an integral part of successful and efficient operation of this industry.
Geography of the COVID-19 pandemic in Ukraine and the world: similarities and differences
Authors: Kholoshyn I V , Nazarenko T G , Mantulenko S V , Mazykina O B , Varfolomyeyeva I M 
Published: December 2024

Abstract
The COVID-19 pandemic has its own geography, reflected in the spatio-temporal model of its regional evolution, with uneven and spatially differentiated worldwide spread. The global nature of the coronavirus pandemic makes it impossible to study its evolution in a single country in isolation from global realities. Comparison of the dynamics of growth in the number of detected cases of coronavirus infection in the world and Ukraine shows that the pandemic is wave-like, but the amplitude, period and length of the variations barely match. Each of the waves of the pandemic in the world and Ukraine had its own characteristics in the spatial and temporal differentiation of the disease parameters, which was determined by various and multidirectional factors. Based on the results of the geospatial analysis, a zoogeographical map of Ukraine’s zoning according to the epidemiological course of the COVID-19 pandemic was constructed, which reflects the spatial differentiation of the pandemic parameters, which is associated with various and multidirectional factors that determine the course of the epidemic, the main ones being: population density and spatial mobility, as well as the peculiarities of regional governance.
Features of the functional zoning of esports arenas taking into account the concepts of sustainable development of territories
Authors: Lobanchykova N M , Yaschenko O F , Lobanchykova V S , Markina L M 
Published: December 2024

Abstract
The development and digitalisation of modern society have created the necessary preconditions for the emergence of new hobbies and sports. Esports has become an integral part of society and is officially recognised at the state level in several countries, including Ukraine. That is why the question arises of the emergence of esports arenas as a new type of architectural typology of public buildings and structures. This publication is devoted to studying the peculiarities of functional zoning of esports arenas, considering the concept of sustainable development of the territory. The article analyses existing esports arenas, computer clubs in the world and Ukraine, and approaches to the organisation and functioning of esports championships. The needs of players and spectators for creating a comfortable space and convenient functional planning of esports arenas are investigated, considering the concept of sustainable development of territories. The proposed solutions are analytical and conceptual, requiring a detailed development of constructive, architectural and design solutions, considering the current standards for public buildings and structures.
Assessment of trends in the functioning of the grain industry of the EU countries using ARDL modeling
Authors: Mandych O V , Staverska T O , Kemza R G , Makohon V V 
Published: December 2024

Abstract
The application of ARDL modeling at the macroeconomic level for the analytical description and analysis of dependencies of production productivity in the grain industry on natural-climatic, technical-technological and marketing factors is studied. It is determined that the construction of the production function for the agrarian sector determines the consideration of internal and external factors of the organization of production and the conditions for its conduct. Another difficult point is the asynchrony of the dynamics of prices for grain and production resources, which necessitates bringing the indicators of costs and output to a comparable form, which determines the artificiality of comparison and non-stationarity of the dynamic series included in the model. It has been proven that the means of overcoming these obstacles is the application of the dependent lag autoregressive model (ARDL). The non-equivalence of the influence of individual factors on the dynamics of yield has been established. In particular, the p-value at the level of one percent has the payback of costs for the production of soft wheat grain in the reporting year, its first and third lag, as well as the second and third lag of payback of costs for the production of durum wheat. At the same time, there is an alternation of the sign of regressors, due to a decrease in prices in years of excess grain production and their increase in lean years. Likewise, the value of the unit cost regressor is also negative, while their lags according to the AIC criterion were not included. The prerequisite for this is the industrial nature of the technologies used. Thus, with an average yield of about 70 c/ha, the variation of the latter over the 29 years of the study did not exceed 7%, and therefore the increase in unit costs, and, accordingly, the yield, but does not provide a simultaneous increase in income due to a decrease in prices. In view of this, a negative value is logical cost regressor. Under such conditions, further study of the prerequisites should be aimed at studying the behavior of lag values of costs and the impact on their formation of a common European policy of regulating the productivity of agricultural production.
Complex socio-economic solutions regarding the sustainable ecological development of the Ukraine regions
Authors: Calinescu T , Likhonosova G , Zelenko O 
Published: December 2024

Abstract
The article presents the current state of the ecological and socio-economic development of Ukraine and its regions, the consequences of hostilities on the territory of Ukraine and, as a consequence, the trends of damage to the surface layer of soils, pollution of the atmospheric air, and the subsoil of Ukraine with heavy metals and other harmful substances. The authors emphasize the socio-economic realities and potential trends of social security for internally displaced persons who were forced to leave their place of residence due to hostilities. Based on the analysis of potential total losses in the regions of Ukraine, a complex of socio-economic solutions is provided for strengthening the sustainable economic and ecological development of its regions. Attention was drawn to the fact that the main environmental problem of Ukraine for the coming decades will remain the problem of demining a large part of the territory. On the basis of the factorization of the given trends, the definition of catalysts of ecological development is proposed, which should signal the need for additional specialized research. It is concluded that despite the importance of solving environmental problems and the catastrophic consequences of hostilities for the surrounding environment, the social component and its economic support are fundamental in the processes of “regeneration” of the normal life activity of the regions.
Calculation of round foundation slabs subjected to non-uniform base deformation under complex loads
Authors: Timchenko R O , Krishko D A , Holovko S I , Holovko O S , Samorodov O V 
Published: December 2024

Abstract
New patterns of determining internal forces for possible conditions of elements of the first and second categories of reinforced concrete slabs subjected to complex loads are established. The introduction into the calculation of a function characterizing the degree of reduction of weakened bases’ properties in order to determine the stiffness coefficient with load relief makes it possible to take into account the conditions of contact interaction between the slab and the non-uniformly deformed base. A program is developed to consider the load history of elements using nonlinear diagrams in the whole range of force and deformation effects. The results of simulating the slab’s operation on a non-uniformly deformed base under complex loads are obtained. The developed program allows determining the maximum load on the structure with known values of expected deformation effects and solving the opposite problem, i.e. determining the maximum deformation effects with constant external loads caused by structures.