bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paleoceanography and ice sheet variability offshore Wilkes Land, Antarctica – Part 3: Insights from Oligocene–Miocene TEX86-based sea surface temperature reconstructions
Authors: Hartman Julian D. , Sangiorgi Francesca , Salabarnada Ariadna , Peterse Francien , Houben Alexander J. P. , Schouten Stefan , Brinkhuis Henk , Escutia Carlota , Bijl Peter K. 
Published: September 2018

Abstract. The volume of the Antarctic continental ice sheet(s) varied
substantially during the Oligocene and Miocene (∼34–5 Ma) from smaller
to substantially larger than today, both on million-year and on orbital
timescales. However, reproduction through physical modeling of a dynamic
response of the ice sheets to climate forcing remains problematic, suggesting
the existence of complex feedback mechanisms between the cryosphere, ocean, and
atmosphere systems. There is therefore an urgent need to improve the models
for better predictions of these systems, including resulting potential future
sea level change. To assess the interactions between the cryosphere, ocean, and
atmosphere, knowledge of ancient sea surface conditions close to the
Antarctic margin is essential. Here, we present a new TEX86-based sea
surface water paleotemperature record measured on Oligocene sediments from
Integrated Ocean Drilling Program (IODP) Site U1356, offshore Wilkes Land,
East Antarctica. The new data are presented along with previously published
Miocene temperatures from the same site. Together the data cover the
interval between ∼34 and ∼11 Ma and encompasses two hiatuses. This
record allows us to accurately reconstruct the magnitude of sea surface
temperature (SST) variability and trends on both million-year and
glacial–interglacial timescales. On average, TEX86 values indicate SSTs
ranging between 10 and 21 ∘C during the Oligocene and Miocene, which
is on the upper end of the few existing reconstructions from other
high-latitude Southern Ocean sites. SST maxima occur around 30.5, 25, and
17 Ma. Our record suggests generally warm to temperate ocean offshore Wilkes
Land. Based on lithological alternations detected in the sedimentary record,
which are assigned to glacial–interglacial deposits, a SST variability of
1.5–3.1 ∘C at glacial–interglacial timescales can be established.
This variability is slightly larger than that of deep-sea temperatures
recorded in Mg ∕ Ca data. Our reconstructed Oligocene temperature
variability has implications for Oligocene ice volume estimates based on
benthic δ18O records. If the long-term and orbital-scale SST
variability at Site U1356 mirrors that of the nearby region of deep-water
formation, we argue that a substantial portion of the variability and trends
contained in long-term δ18O records can be explained by variability
in Southern high-latitude temperature and that the Antarctic ice volume may
have been less dynamic than previously thought. Importantly, our temperature
record suggests that Oligocene–Miocene Antarctic ice sheets were generally of
smaller size compared to today.
Clast imbrication in coarse-grained mountain streams and stratigraphic archives as indicator of deposition in upper flow regime conditions
Authors: Schlunegger Fritz , Garefalakis Philippos 
Published: September 2018

Abstract. Clast imbrication is one of the most conspicuous sedimentary structures in coarse-grained clastic deposits of modern rivers but also in the stratigraphic record. In this paper, we test whether the formation of this fabric can be related to the occurrence of upper flow regime conditions in streams. To this end, we calculated the Froude number at the incipient motion of coarse-grained bedload for various values of relative bed roughness and stream gradient as these are the first-order variables that can practically be extracted from preserved deposits. We found that a steeper energy gradient, or slope, and a larger bed roughness tend to favor the occurrence of supercritical flows. We also found that, at the onset of grain motion, the ratio ϕ between the critical shear stress for the entrainment of a sediment particle and its inertial force critically controls whether flows tend to be super- or subcritical during entrainment. We then mapped the occurrence of clast imbrication in Swiss streams and compared these data with the hydrologic calculations. Results indicate that imbrication may record supercritical flows provided that (i) ϕ values are larger than ca. 0.05, which is appropriate for streams in the Swiss Alps; (ii) average stream gradients exceed ca. 0.5 ± 0.1°; and (iii) relative bed roughness values, i.e., the ratio between water depth d and bed sediment D84, are larger than  ∼ 0.06 ± 0.01. We cannot rule out that imbrication may be formed during subcritical flows with ϕ values as low as 0.03, as demonstrated in a large number of flume experiments. However, our results from Alpine streams suggest that clast imbrication likely reflects upper flow regime conditions where clasts form well-sorted and densely packed clusters. We consider that these differences may be rooted in a misfit between the observational and experimental scales.
Complejidad y sostenibilidad de dos agroecosistemas con cacao, Siuna 2017
Authors: Altamirano Hernández Iris Jamileth , Amador López Mario Feliciano , Montalván Castellón Oscar 
Published: September 2018

Esta investigación se realizó en la comunidad El Carao-Hormiguero, Siuna, 2017, en las fincas Los Laureles del Sr. German Valerio Pérez y El Encanto del Sr. Carlos López Lagos, con el fin de evaluar la complejidad y sostenibilidad de dos agro ecosistemas con cacao a través de manejo de biodiversidad en los agroecosistemas y determinar el nivel de sostenibilidad en el aspecto sociocultural, económico y agro-ambiental. Se aplicaron dos metodologías, Vázquez (2013) la cual evalúa seis indicativos y 64 indicadores, se miden con un rango de (0-4) siendo este un valor estándar para medir el nivel de complejidad de los sistemas de producción y HESOFI (2015) que evalúa 71 indicadores, 12 componentes y 3 criterios, sociocultural, económicos y agro-ambiental y para cada criterio se asigna un valor de 100. El coeficiente y manejo de la biodiversidad en la finca Los Laureles es medianamente complejo con un nivel del 2.61 (56.71%) con un índice satisfactorio y El Encanto 1.60 (33.44%), determinándose como un sistema de producción poco complejo con índice medianamente satisfactorio. El nivel de sostenibilidad que miden las dimensiones socio-cultural, económica y agro-ambiental para la finca El Encanto fue de 132 de 300, su fuerza radica en lo sociocultural con (66%), agro-ambiental con (41%) y económico con un (25%). Los Laureles presentó un valor de 202 de 300, su mayor fuerte fue lo sociocultural (75%), lo agro- ambiental (69%) y lo económico (58%). Tales resultados indican que Los Laureles cuenta con un grado de sostenibilidad del (67.40%), y El Encanto con (44.19%).
Ontslag van statutair bestuurders – een recap
Authors: Attaïbi A. 
Published: September 2018

Ontslag van statutair bestuurders – een recap
In deze bijdrage bespreekt de auteur het ontslag van bestuurders vanuit vennootschapsrechtelijk en arbeidsrechtelijk perspectief, waarbij recente wetgeving, rechtspraak en literatuur de revue passeren. Meer in het bijzonder gaat de auteur in op de (ver)nietig(baar)heid van ontslagbesluiten, het arbeidsrechtelijk vereiste van een ‘redelijke grond’ voor ontslag en hoe dit zich verhoudt tot de vennootschapsrechtelijke ‘te allen tijde’-ontslagbevoegdheid van de aandeelhoudersvergadering, alsook (de begroting van) de billijke vergoeding aan bestuurders.
Testing the FAIR metrics on data catalogs
Authors: van Erp Jarno A A , Langen Carolyn D , Boon Anca , van Bochove Kees 
Published: September 2018

The introduction of the FAIR –Findable, Accessible, Interoperable, Reusable– principles has caused quite an uproar within the scientific community. Principles which, if everyone adheres to them, could result in new, revolutionary ways of performing research and fulfill the promise of open science. Furthermore, it allows for concepts such as personalized medicine and personal health monitoring to -finally- become implemented in daily practice.
However, to bring about these changes, data users need to rethink the way they treat scientific data. Just passing a dataset along, without extensive metadata will not suffice anymore. Such new ways of executing research require a significantly different approach from the entire scientific community or, for that matter, anyone who wants to reap the benefits from going FAIR.
Yet, how do you initiate behavioral change? One important solution is by changing the software scientists use and requiring data owners, or data stewards, to FAIRify their dataset. Data catalogs are a great starting point for FAIRifying data as the software already intends to make data Findable and Accessible, while the metadata is Interoperable and relying on users to provide sufficient metadata to ensure Reusability. In this paper we analyse how well the FAIR principles are implemented in several data catalogs.
To determine how FAIR a catalog is, the FAIR metrics were created by the GO-FAIR initiative. These metrics help determine to what extend data can be considered FAIR. However, the metrics were only recently developed, being first released at the end of 2017. At the moment software does not come standard with a FAIR metrics review. Still, this insight is highly desired by the scientific community. How else can they be sure that (public) money is spend in a FAIR way?
The Hyve has tested/evaluated three popular open source data catalogs based on the FAIR metrics: CKAN, Dataverse, and Invenio. Most data stewards will be familiar with at least one of these.
Within this white paper we provide answers to the following questions:
Which of the three data catalogs performs best in making data FAIR?
Which data catalog utilizes FAIR datasets the most?
Which one creates the most FAIR metadata?
Which catalog has the highest potential to increase its FAIRness, and how?
Which data catalog facilitates the FAIRifying process the best?
Extent of use of long-acting injectable antipsychotics in children and adolescents within Indiana Medicaid
Authors: Modesitt Taylor , Kubascik Erica , Ott Carol 
Published: September 2018

Abstract

Introduction:
Oral formulations of the antipsychotics aripiprazole, asenapine, lurasidone, olanzapine, paliperidone, quetiapine, and risperidone are indicated for use in pediatrics for several diagnoses. Long-acting injectable (LAI) antipsychotics are of interest in this special population because they may be used due to convenience and desire to improve adherence, despite limited support in the literature. The primary intent of this study is to provide descriptive information on the use of paliperidone palmitate, risperidone microspheres, aripiprazole extended-release injection, and olanzapine pamoate in pediatric patients within Indiana Medicaid.

Methods:
This study was a retrospective database analysis, which retrieved information from Indiana Medicaid over a 2-year timeframe spanning from July 1, 2012, through June 30, 2014. The study included the prescription medications filled for all children and adolescents within Indiana Medicaid who received the LAI antipsychotics paliperidone palmitate, risperidone microspheres, aripiprazole extended-release injection, and olanzapine pamoate.

Results:
From July 1, 2012, through June 30, 2014, 150 Indiana Medicaid patients younger than 18 years old were prescribed a LAI atypical antipsychotic. A total of 1013 LAI atypical antipsychotic doses were billed to Indiana Medicaid during the study period for pediatric patients. Paliperidone palmitate was billed most frequently.

Discussion:
Long-acting injectable atypical antipsychotics are being prescribed for children and adolescents within Indiana Medicaid, despite minimal clinical evidence supporting use. There is a need for further research in this area to increase generalizability of results and aid in implementation of policies to prevent inappropriate use of LAI antipsychotics in children and adolescents.
Self-stigma of antidepressant users through secondary analysis of PhotoVoice data
Authors: Nelson Erik , Werremeyer Amy , Kelly Gina Aalgaard , Skoy Elizabeth 
Published: September 2018

Abstract

Introduction:
Aspects of self-stigma and medication-related stigma among individuals with depressive disorders remain largely unexplored. The primary objective of this study is to highlight and characterize self-stigma and medication-related stigma experiences of antidepressant users.

Methods:
This is a secondary analysis of data obtained from PhotoVoice studies examining psychotropic medication experiences. Transcripts of reflections from 12 individuals self-reporting a depressive disorder diagnosis and receipt of a prescription for an antidepressant were included. A directed content analysis approach based on expansion of the Self-Stigma of Depression Scale and an iterative process of identification of medication-stigma and stigma-resistance were used. Total mentions of self-stigma, stigma resistance, medication stigma, and underlying themes were tallied and evaluated.

Results:
Self-stigma was mentioned a total of 100 times with at least 2 mentions per participant. Self-blame was the most prominent construct of self-stigma and was mentioned nearly twice as often as any other self-stigma construct. Most participants also made mentions of self-stigma resistance. Half of the individual participants mentioned stigma resistance more times than they mentioned self-stigma, which suggests some surmounting of self-stigma. Medication-related stigma was also prominent, denoting negativity about the presence of medications in one's life.

Discussion:
Self-stigma related to self-blame may be problematic for antidepressant users. Identification and measurement of stigma resistance, especially in peer interactions, may represent a promising concept in overcoming self-stigma. Future work should explore emphasizing self-blame aspects when designing interventions to reduce self-stigma among individuals with depressive disorders and explore development of tools to measure stigma resistance.
Changing student attitudes and perceptions toward opioid use disorder
Authors: Countey Haley , Steinbronn Claire , Grady Sarah E. 
Published: September 2018

Abstract

Introduction:
With the opioid epidemic creating a group of patients with unique health care needs, pharmacists have an opportunity to be a good resource for patients recovering from opioid use disorder (OUD). To accomplish this, it is essential that pharmacists are knowledgeable and unbiased toward this patient population.

Methods:
Because the curriculum in place to obtain a PharmD at Drake University does not include in-depth information on substance use disorders, study investigators offered students an opportunity to receive more intensive education. Faculty members at Drake University provided didactic and panel discussion presentations on topics such as opioid pharmacology, OUD, and treatment options. The students were assessed for their perception of knowledge and stigma before and after the summit by using a 5-point Likert scale to measure their attitudes toward 10 statements.

Results:
Total knowledge scores showed a significant change of 3.1, indicating an increase in perceived understanding of materials presented (P &lt; .0001). Total stigma scores also changed by 1.4, illustrating a statistically significant decrease in negative perceptions (P = .0198).

Discussion:
By providing more in-depth education, the summit showed that increasing pharmacy student knowledge about OUD and its treatment may decrease associated stigma.
Evaluation of perceptions and knowledge of mental illness in the United States through crowdsourcing
Authors: Palmer Emma C. , Douglass Amber R. , Smith Thomas , Fuentes David G. 
Published: September 2018

Abstract

Introduction:
Crowdsourcing is a method of data collection with possible benefits in assessing perceptions of mental illness in a large US population.

Methods:
The objective was to describe perceptions and trends of stigma surrounding mental illness in the United States using crowdsourcing. An online survey was conducted evaluating adults in the United States recruited via the online resource Amazon Mechanical Turk. Questions evaluated demographics and perceptions of mental illness. Survey data were adjusted for demographic variables and compared via logistic regression.

Results:
Respondents (n = 1422) were predominately 18 to 30 years of age (n = 743; 52.3%) and white (n = 1101; 77.4%). Over half reported an individual close to them had mental illness (n = 932; 65.5%), and more than one quarter (n = 397; 27.9%) reported having a current or previous mental illness. Non-whites were less likely to agree that: medications are effective (odds ratio [OR] 0.63); they would be comfortable around a coworker with mental illness (OR 0.66); and mental illness is inheritable (OR 0.74). They are also more likely to agree that mental illness is preventable (OR 1.49). Individuals reporting mental illness were more likely to agree that medications (OR 1.34; 95% confidence interval 1.03 to 1.74) and talk therapy (OR 1.46; 95% confidence interval 1.12 to 1.90) are effective. Those reporting some or no college were more likely to agree that the United States has good access to mental health treatment.

Discussion:
Crowdsourcing may be an effective way to obtain information regarding demographics, stigma, and mental illness. Personal experiences with mental illness, ethnicity, and educational level appear to continue to impact perceptions of mental illness.
Rechallenge of lamotrigine after development of rash
Authors: Houser Jennifer , Graham Ashley 
Published: September 2018

Abstract
Lamotrigine (LTG) is associated with the potential for a life-threatening rash (eg, Stevens-Johnson syndrome or toxic epidermal necrolysis). The incidence has been linked to rapid titration and an interaction with valproic acid that can increase the level of LTG. Providers often have difficulty discriminating between serious versus benign rashes, and the package insert recommends discontinuing the medication at the first sign of a rash. Therefore, many patients end up being taken off LTG when it may have been effective for them. We present a case where LTG is reintroduced with a faster initial titration than what is noted in the literature after development of a rash. This case is also unique in that the patient had been on LTG for years prior to emergence of the rash and demonstrates that retrials can be successful.
Most Robust and Fragile States with the Same Entanglement Properties
Authors: Li Hong‐Mei , Zhao Bao‐Kui 
Published: September 2018

AbstractFinding the most robust entangled states and the most fragile entangled states during the whole process of decoherence is particularly a fundamental problem for quantum physics and quantum information processing. Here the robustness of three‐qubit states under three different decoherence channels (amplitude damping, dephasing, bit flip) systematically are investigated, and the most robust genuine tripartite entangled states and the most fragile ones during each of the three decoherence processes are found. Moreover, the states with the most significant difference in robustness are shown to be locally unitarily equivalent to each other and therefore contain the same entanglement properties.
Auf der Suche nach der verlorenen Kultur: Vom Neuroimaging über Critical Neuroscience zu Cultural Neuroscience – und zurück zur Kritik
Authors: Borck Cornelius 
Published: September 2018

AbstractIn Search of Lost Culture: From Neuroimaging via Critical Neuroscience to Cultural Neuroscience – and back to Critique. The availability of new technologies for visualizing brain activity generated great expectations to identify the centers responsible for human action and behavior and to “reduce” all mental processes to neuronal states. Some scientists even called society to adapt to the new insights from brain research by giving up outdated concepts of autonomy and free will. This project spurred harsh critiques from philosophy, sociology, and cultural studies, diagnosing the rise of a new phrenology. A critical neuroscience group took up these criticisms and pledged for a more nuanced reflection about the political, historical and ethical contexts and implications of current neuroscience and argued for an integration of societal concerns into the research agenda – rather similar to the agenda for responsible research of the EU. With the development of more sophisticated visualization strategies, new sub‐disciplines emerged, integrating sociocultural aspects into neuroimaging. Social and cultural neuroscience replaced overstated reductionist claims without leaving the overarching naturalist epistemology, but extending the ontological realm. New research objects such as empathy, religion or ‘Western’ vs. ‘East‐Asian’ attitudes of thinking started to populate the research domain. Especially cultural neuroscience was widely celebrated as new scientific bridge across the nature‐culture gulf. A closer look, however, reveals that this claim and the popular success of cultural neuroscience are based on a decisive lack of conceptual clarity. ‘Culture’ functions as fuzzy denominator for a broad range of social phenomena with unknown links to neurophysiological processes but visualized as brain states. Instead of implementing more reflexive forms of research, cultural neuroscience stabilizes problematic stereotypes and racist attitudes by an expansion of neuro‐culture. In light of this deflation of interdisciplinary cooperation a more radical critique of this ideology seems in place.
The association between mean platelet volume levels and poststroke depression
Authors: Qiu Huihua , Liu Yuntao , He Hongfei , Wu Yuemin , He Weilei , Huang Guiqian , He Jincai 
Published: September 2018

AbstractObjectiveHigh levels of mean platelet volume (MPV) had been found in depression subjects. We sought to examine the relationship between MPV and poststroke depression (PSD).MethodsOne hundred and eighty‐five patients with acute ischemic stroke were enrolled in our study. Peripheral venous blood samples were drawn at admission and MPV levels were measured by the automated hematology analyzer. Patients with a HAMD‐17 score >7 were diagnosed as having PSD.ResultsWe found that 60 patients (32.4%) developed PSD, the MPV levels in PSD patients were significantly higher (9.3 ± 1.8 fl) compared to non‐PSD patients (8.5 ± 1.6 fl). High MPV levels (≥9.1 fl) were independently correlated with PSD (OR 2.762, 95% CI 1.138–6.702, p = 0.025).ConclusionsPatients with higher levels of MPV at admission were correlated with the development of PSD at 1 month after stroke and might be a predictor of its presence.
Intractable pneumothorax complicated with interstitial pneumonitis treated with the Tachosuture technique: A case report
Authors: Uchida Tsuyoshi , Matsubara Hirochika , Sugimura Aya , Matsuoka Hiroyasu , Ichihara Tomofumi , Nakajima Hiroyuki 
Published: September 2018

Key Clinical MessageIt has been proven that the Tachosuture technique is effective for preventing prolonged air leaks caused by pulmonary resection. We successfully used the Tachosuture technique to treat intractable pneumothorax with interstitial pneumonia. This technique avoids pulmonary resection and contributes to acute exacerbations of interstitial pneumonia.