bluuebunny/crossref_metadata_2025_split huggingface dataset:
Al-Sharīf al-Murtaḍā’s Responses to Theological Questions posed by Abū Yaʿlā Sallār [Sālār] b. ʿAbd al-ʿAzīz al-Daylamī (d. 448/1057): A Critical Edition
Authors: Ansari Hassan , Schmidtke Sabine 
Published: June 2018

AbstractAmong the responsa collections by al-Sharīf al-Murtaḍā that still remain to be edited are theJawābāt al-masāʾil al-Sallāriyya, which consist of responsa to eight questions most of which revolve around issues related to the subtleties ofkalām. On the basis of the two earliest witnesses of this text,MSBerlin, Staatsbibliothek zu Berlin, Petermann II[Pm.] 169 andMSMashhad, Āstān-i quds 1448, an edition has been prepared.
A Zaydī Treatise on the Proof of Accidents: The Mukhtaṣar fī ithbāt al-aʿrāḍ by al-Ḥasan al-Raṣṣāṣ
Authors: Thiele Jan 
Published: June 2018

AbstractThis article provides a description and critical edition of al-Ḥasan al-Raṣṣāṣ’sMukhtaṣar fī ithbāt al-aʿrād. The work appears to be extracted from a larger treatise. It is concerned with the proof of the reality of “accidents”, a central concept in the ontology ofkalām.
Bureaucratic reputation in the eyes of citizens: an analysis of US federal agencies
Authors: Lee Danbee , Van Ryzin Gregg G. 
Published: June 2018

Bureaucratic reputation has been defined as a set of beliefs about a public organization’s capacities, roles, and obligations that are embedded in a network of multiple audiences (Carpenter, 2010). Although one of the most important audiences in a democracy is the citizenry, very little empirical investigation has looked at citizens’ beliefs about specific government agencies and what individual or contextual factors influence these beliefs. To examine this question, this study analyzes data from a unique 2013 Pew Political Survey that represents the responses of 1500 US citizens on the reputations of 12 federal agencies. Results demonstrate that citizens view the reputations of some agencies (such as the CDC and NASA) much more favorably than other agencies (such as the IRS and the Department of Education). In regression analyses, findings suggest that the reputation of federal agencies varies according to citizens’ general level of trust in government and their political ideology, but that demographic, socioeconomic and regional differences also shape reputation judgments. These findings provide some preliminary empirical understanding of the reputation of government agencies in the eyes of the citizenry and may have implications for agencies seeking to manage their relationship with the public. Points for practitioners Bureaucratic reputation has important implications for public administrators because of its influence on a government agency’s autonomy, power, and legitimacy. Our study examines the reputations of 12 US federal government agencies and identifies individual and contextual determinants of citizens’ reputation ratings. We demonstrate that reputations differ between agencies and that certain factors – especially political ideology and trust in government – shape how the public views an agency’s reputation. These findings can help practitioners understand better how to strategically manage their agency’s reputation given an increasingly critical citizenry.
Do Death Certificates Underestimate the Burden of Rare Diseases? The Example of Systemic Lupus Erythematosus Mortality, Sweden, 2001-2013
Authors: Falasinnu Titilola , Rossides Marios , Chaichian Yashaar , Simard Julia F. 
Published: June 2018

Objectives: Mortality due to rare diseases, which are substantial sources of premature mortality, is underreported in mortality studies. The objective of this study was to determine the completeness of reporting systemic lupus erythematosus (SLE) as a cause of death. Methods: In 2017, we linked data on a Swedish population-based cohort (the Swedish Lupus Linkage, 2001-2013) comprising people with SLE (n = 8560) and their matched general population comparators (n = 37 717) to data from the Cause of Death Register. We reviewed death records of deceased people from the cohort (n = 5110) and extracted data on patient demographic characteristics and causes of death. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for not reporting SLE as a cause of death by using multivariable-adjusted logistic regression models. Results: Of 1802 deaths among SLE patients in the study, 1071 (59%) did not have SLE reported on their death records. Most SLE decedents were aged 75-84 at death (n = 584, 32%), female (n = 1462, 81%), and born in Nordic countries (n = 1730, 96%). Decedents aged ≥85 at death were more likely to have SLE not reported on their death records than were decedents aged <50 (OR = 2.34; 95% CI, 1.48-3.68). Having renal failure listed as a cause of death decreased the likelihood of SLE not being reported on the death record (OR = 0.54; 95% CI, 0.40-0.73), whereas having cancer listed as a cause of death increased this likelihood (OR = 2.39; 95% CI, 1.85-3.07). Conclusions: SLE was greatly underreported as a cause of mortality on death records of SLE patients, particularly in older decedents and those with cancer, thereby underestimating the true burden of this disease. Public health resources need to focus on improving the recording of rare diseases in order to enhance the epidemiological utility of mortality data.
The galanin receptor-3 antagonist, SNAP 37889, inhibits cue-induced reinstatement of alcohol-seeking and increases c-Fos expression in the nucleus accumbens shell of alcohol-preferring rats
Authors: Wilson Kira-Elise , Limburg Sigrid , Duggan Melissa K , Lawther Adam J , Williams Spencer J , Lawrence Andrew J , Hale Matthew W , Djouma Elvan 
Published: June 2018

Introduction: This study aimed to investigate the effects of the galanin-3 receptor antagonist, SNAP 37889, on c-Fos protein expression after cue-induced reinstatement of alcohol-seeking in the brains of alcohol-preferring rats. Methods: Eighteen alcohol-preferring rats were trained to self-administer 10% v/v ethanol in the presence of response-contingent cues, which was followed by extinction. Rats were then treated with SNAP 37889 (30 mg/kg, i.p.) or vehicle, before being tested for cue-induced reinstatement. Administration of SNAP 37889 reduced cue-induced reinstatement of ethanol-seeking behaviour. To examine the effect of SNAP 37889 and cue-induced reinstatement on neuronal activation, c-Fos expression was measured in subregions of the medial prefrontal cortex and nucleus accumbens. Results: SNAP 37889 administration increased c-Fos immunoreactivity in the nucleus accumbens shell, but was without effect in the nucleus accumbens core and the medial prefrontal cortex. Dual-label Fos/tyrosine hydroxylase immunohistochemistry was used to examine the effects of SNAP 37889 on dopamine neurons in the ventral tegmental area; however, no differences between SNAP 37889 and vehicle-treated rats were found. Conclusions: These data support previous findings of galanin-3 receptor involvement in cue-induced reinstatement of alcohol-seeking behaviour, and provide novel evidence that the ability of galanin-3 receptor antagonism to attenuate cue-induced reinstatement relates to activation of the nucleus accumbens shell.
Older adults' experiences of daily life occupations as everyday technology changes
Authors: Ryd Charlotta , Malinowsky Camilla , Öhman Annika , Kottorp Anders , Nygård Louise 
Published: June 2018

Introduction Knowledge is lacking of how technological development has affected occupational engagement and performance. Changes in the environment, for example, new technology, are likely to create changes in the dynamics of occupations and exploring this among older adults is especially important. This study aimed to explore what can drive and hinder the incorporation of everyday technology into occupations and how new technology affects occupational engagement and performance among older adults. Method A constructivist grounded theory methodology was applied. Data were collected by individual interviews with six women and five men between the ages of 67 and 92 years old. Participants also varied as regards their cognitive function and living conditions. Results The findings concerned the match between technology and the participants' perceptions of occupational purposes, needs of control and safety, and the kind of technology user they strived to be. A good match was a driving force for technology usage and satisfaction with the altered occupations and vice versa. Conclusion Occupational engagement and performance in relation to technology use can be facilitated, which is useful knowledge for stakeholders developing and implementing new technology, as well as those who encounter older adults with the needs or desire to use technology in their daily occupations.
Effectiveness of Workplace Lactation Interventions on Breastfeeding Outcomes in the United States: An Updated Systematic Review
Authors: Kim Julia H. , Shin Jong C. , Donovan Sharon M. 
Published: June 2018

Background Returning to work is one of the main barriers to breastfeeding duration among working mothers in the United States. However, the impact of workplace lactation programs is unclear. Research Aim The aim of this study was to evaluate the effectiveness of workplace lactation programs in the United States on breastfeeding practices. Methods A systematic search was conducted of seven databases through September 2017. Articles ( N = 10) meeting the inclusion criteria of describing a workplace lactation intervention and evaluation in the United States and measuring initiation, exclusivity, or duration using an experimental or observational study design were critically evaluated. Two reviewers conducted quality assessments and reviewed the full-text articles during the analysis. Results Common services provided were breast pumps, social support, lactation rooms, and breastfeeding classes. Breastfeeding initiation was very high, ranging from 87% to 98%. Several factors were significantly associated with duration of exclusive breastfeeding: (a) receiving a breast pump for one year (8.3 versus 4.7 months), (b) return-to-work consultations (40% versus 17% at 6 months), and (c) telephone support (42% versus 15% at 6 months). Each additional service (except prenatal education) dose-dependently increased exclusively breastfeeding at 6 months. Sociodemographic information including older maternal age, working part-time, longer maternity leave, and white ethnicity were associated with longer breastfeeding duration. Conclusion Workplace lactation interventions increased breastfeeding initiation, duration, and exclusive breastfeeding, with greater changes observed with more available services. More evidence is needed on the impact of workplace support in low-income populations, and the cost-effectiveness of these programs in reducing health care costs.
The Burden of Moderate to Severe Atopic Dermatitis in Canadian Children: A Cross-Sectional Survey
Authors: Bridgman Alanna C. , Eshtiaghi Panteha , Cresswell-Melville Amanda , Ramien Michele , Drucker Aaron M. 
Published: June 2018

Objectives: Although atopic dermatitis (AD) has significant impacts on quality of life, data from Canada on the subject are limited. This survey aims to assess the burden of moderate to severe AD on quality of life and disease management for pediatric patients and their caregivers in Canada. Methods: The Eczema Society of Canada conducted an online national cross-sectional survey in English and French. We included children with self-reported moderate to severe AD. We present descriptive statistics from the survey. Results: Of all initial respondents (n = 658), 70% (n = 458) were children or caregivers of children who have moderate or severe AD and were therefore eligible. Among them, 27% (123/451) are managed by a dermatologist, with 71% (174/244) waiting more than 3 months to see a dermatologist. Many respondents (85%, 279/330) feel that their child’s AD is not well controlled, and 27% (75/275) have difficulty obtaining treatments for their child’s AD. Impaired quality of life was found in 52% of families (200/381), with most reporting sleep disturbances in both the child (70%, 253/361) and the caregiver (55%, 199/361), as well as mental health issues. Conclusions: This survey demonstrates the medical and psychosocial burden of moderate to severe AD in Canadian children. Quality of life, access to care, and disease management are all areas of concern for patients and their families and warrant attention from individual clinicians and the health care system as a whole.
Vedolizumab and early postoperative complications in nonintestinal surgery: a case-matched analysis
Authors: Kotze Paulo Gustavo , Ma Christopher , Mckenna Nicholas , Almutairdi Abdulelah , Kaplan Gilaad G. , Raffals Laura E. , Loftus Edward V. , Panaccione Remo , Lightner Amy L. 
Published: June 2018

Background: Vedolizumab (VDZ) is a gut-specific α4-β7 integrin antagonist that has demonstrated efficacy in Crohn’s disease (CD) and ulcerative colitis (UC). The safety of VDZ in the perioperative period remains unclear. The aim of this study was to evaluate postoperative complications and perioperative safety in VDZ-treated patients undergoing nonintestinal operations. Methods: A case-matched study was performed at two inflammatory bowel disease (IBD) referral centers. Adult patients with CD and UC who underwent a nonintestinal surgical procedure during treatment with VDZ were included. Patients who had their last VDZ infusion up to 12 weeks before the procedure were considered exposed and were matched in a 1:1 ratio to patients without VDZ therapy, according to type of surgical procedure, age, and sex. The primary outcome was overall risk of early postoperative infectious complications (up to 30 days after surgery), readmissions, reoperations, surgical site infections, and other infections. The VDZ and control groups were subsequently compared using the Pearson χ2 test and Wilcoxon rank sum. Results: We identified 34 patients treated with VDZ who underwent 36 nonintestinal surgical procedures. These patients were matched with 36 control procedures. Postoperative complications were not different between the VDZ-treated and control cohorts for all outcomes analyzed: infectious complications occurred in 14% versus 8% ( p = 0.45), superficial surgical site infections 6% versus 0% ( p = 0.15), reoperations 6% versus 3% ( p = 0.56) and readmissions 11% versus 6% ( p = 0.37). Conclusions: VDZ-treated patients with IBD undergoing nonintestinal procedures did not have an increased risk of overall postoperative infections or other complications compared with matched controls.
Cerebral small vessel disease in Indonesia: Lacunar infarction study from Indonesian Stroke Registry 2012–2014
Authors: Harris Salim , Kurniawan Mohammad , Rasyid Al , Mesiano Taufik , Hidayat Rakhmad 
Published: June 2018

Background and Purpose: Stroke is the number one cause of morbidity and mortality in Indonesia. Lacunar infarction is one of cerebral small vessel disease spectrum. This study aimed to present stroke epidemiology in Indonesia and risk factors associated with cerebral small vessel disease. Methods: A multicenter prospective cross-sectional study of 18 hospitals in Indonesia was conducted using Stroke Case Report Form from 2012 to 2014. Stroke was diagnosed based on clinical findings confirmed with non-contrast computed tomography of the brain. Subjects were classified into two large groups: ischemic (lacunar and non-lacunar) and hemorrhagic (intracranial and subarachnoid hemorrhage). Other risk factors were assessed on admission. Results: We enrolled 5411 patients, of whom 3627 (67.03%) had ischemic stroke and 1784 (32.97%) had hemorrhagic stroke. Male patients were prevalent in both large groups, although found less in subarachnoid hemorrhage group. Among patients with hemorrhagic stroke, 1603 (89.54%) of them had intracerebral hemorrhage and 181 (10.46%) had subarachnoid hemorrhage. From 3627 ischemic stroke patients, 1635 (45.07%) of them had lacunar infarction. We found that age above 55 years old, male gender, hypertension, dyslipidemia, and diabetes were important risk factors associated with lacunar stroke (p < 0.05). Conclusion: Ischemic stroke was the leading cause of stroke in Indonesia. In total, 45% of the total ischemic stroke patients had lacunar infarction. Important risk factors associated with lacunar infarction were hypertension, dyslipidemia, diabetes, age over 55, and male population.
Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations
Authors: Pellagatti Andrea , Armstrong Richard N. , Steeples Violetta , Sharma Eshita , Repapi Emmanouela , Singh Shalini , Sanchi Andrea , Radujkovic Aleksandar , Horn Patrick , Dolatshad Hamid , Roy Swagata , Broxholme John , Lockstone Helen , Taylor Stephen , Giagounidis Aristoteles , Vyas Paresh , Schuh Anna , Hamblin Angela , Papaemmanuil Elli , Killick Sally , Malcovati Luca , Hennrich Marco L. , Gavin Anne-Claude , Ho Anthony D. , Luft Thomas , Hellström-Lindberg Eva , Cazzola Mario , Smith Christopher W. J. , Smith Stephen , Boultwood Jacqueline 
Published: June 2018

Key Points
RNA-seq analysis of CD34+ cells identifies novel aberrantly spliced genes and dysregulated pathways in splicing factor mutant MDS. Aberrantly spliced isoforms predict MDS survival and implicate dysregulation of focal adhesion and exosomes as drivers of poor survival.
RETRACTED ARTICLE: Systematic analyses reveal long non-coding RNA (PTAF)-mediated promotion of EMT and invasion-metastasis in serous ovarian cancer
Authors: Liang Haihai , Zhao Xiaoguang , Wang Chengyu , Sun Jian , Chen Yingzhun , Wang Guoyuan , Fang Lei , Yang Rui , Yu Mengxue , Gu Yunyan , Shan Hongli 
Published: June 2018

Abstract
Background
A deeper mechanistic understanding of epithelial-to-mesenchymal transition (EMT) regulation is needed to improve current anti-metastasis strategies in ovarian cancer (OvCa). This study was designed to investigate the role of lncRNAs in EMT regulation during process of invasion-metastasis in serous OvCa to improve current anti-metastasis strategies for OvCa.

Methods
We systematically analyzes high-throughput gene expression profiles of both lncRNAs and protein-coding genes in OvCa samples with integrated epithelial (iE) subtype and integrated mesenchymal (iM) subtype labels. Mouse models, cytobiology, molecular biology assays and clinical samples were performed to elucidate the function and underlying mechanisms of lncRNA PTAF-mediated promotion of EMT and invasion-metastasis in serous OvCa.

Results
We constructed a lncRNA-mediated competing endogenous RNA (ceRNA) regulatory network that affects the expression of many EMT-related protein-coding genes in mesenchymal OvCa. Using a combination of in vitro and in vivo studies, we provided evidence that the lncRNA PTAF-miR-25-SNAI2 axis controlled EMT in OvCa. Our results revealed that up-regulated PTAF induced elevated SNAI2 expression by competitively binding to miR-25, which in turn promoted OvCa cell EMT and invasion. Moreover, we found that silencing of PTAF inhibited tumor progression and metastasis in an orthotopic mouse model of OvCa. We then observed a significant correlation between PTAF expression and EMT markers in OvCa patients.

Conclusions
The lncRNA PTAF, a mediator of TGF-β signaling, can predispose OvCa patients to metastases and may serve as a potential target for anti-metastatic therapies for mesenchymal OvCa patients.
Standard Chemoradiation and Conventional Brachytherapy for Locally Advanced Cervical Cancer: Is It Still Applicable in the Era of Magnetic Resonance–Based Brachytherapy?
Authors: Mittal Prachi , Chopra Supriya , Pant Sidharth , Mahantshetty Umesh , Engineer Reena , Ghosh Jaya , Gupta Sudeep , Ghadi Yogesh , Menachery Siji , Swamidas Jamema , Gurram Lavanya , Shrivastava Shyam Kishore 
Published: June 2018

Purpose Recent guidelines recommend magnetic resonance imaging–based brachytherapy (MRBT) for locally advanced cervical cancer. However, its implementation is challenging within the developing world. This article reports the outcomes of patients with locally advanced cervical cancer treated with chemoradiation and point A–based brachytherapy (BT) using x-ray– or computed tomography–based planning. Methods Patients treated between January 2014 and December 2015 were included. Patients underwent x-ray– or computed tomography–based BT planning with an aim to deliver equivalent doses in 2 Gy (EQD2) > 84 Gy10 to point A while minimizing maximum dose received by rectum or bladder to a point or 2 cc volume to < 75 Gy EQD2 and < 90 Gy EQD2, respectively. The impact of known prognostic factors was evaluated. Results A total of 339 patients were evaluated. Median age was 52 (32 to 81) years; 52% of patients had stage IB2 to IIB and 48% had stage III to IVA disease. There was 85% compliance with chemoradiation, and 87% of patients received four or more cycles. Median point A dose was 84 (64.8 to 89.7) Gy. The median rectal and bladder doses were 73.5 (69.6 to 78.4) Gy3 and 83 (73.2 to 90.0) Gy3, respectively. At a median follow-up of 28 (4 to 45) months, the 3-year local, disease-free, and overall survival for stage IB to IIB disease was 94.1%, 83.3%, and 82.7%, respectively. The corresponding rates for stage III to IVA were 85.1%, 60.7%, and 69.6%. Grade III to IV proctitis and cystitis were observed in 4.7% and 0% of patients, respectively. Conclusion This audit demonstrates good 3-year outcomes that are comparable to published MRBT series. Conventional BT with selective use of interstitial needles and MRBT should continue as standard procedures until level-I evidence for MRBT becomes available.
The Texas Conservation Plan has not slowed oil and gas well development in dunes sagebrush lizard habitat
Authors: Malcom Jacob , Moskwik Matthew 
Published: June 2018

Background: The dunes sagebrush lizard (Sceloporus arenicolus) is an imperiled species that is restricted to shinnery oak (Quercus havardii) sand dune habitats in southeastern New Mexico and West Texas, USA. This region is also a hotspot of oil and gas development that is a major threat to the species. Methods: Here we use well data and a natural experiment to test the effectiveness of voluntary conservation agreements for slowing or stopping oil and gas well approval in the lizard’s habitat in New Mexico and Texas. Results: We show that the Candidate Conservation Agreement (CCA) and CCA with Assurances in New Mexico, both of which contain strong avoidance mechanisms, are associated with a steep decline in oil and gas well approval in the New Mexico portion of the lizard’s range, but not outside the lizard’s range. By contrast, the Texas Conservation Plan (TCP), which does not include mandatory avoidance, is not associated with any decline of oil and gas well approval in the lizard's Texas range relative to the broader landscape. Conclusions: These results indicate that the TCP is insufficient to conserve the lizard in Texas, thereby jeopardizing genetic and geographic representation across the range of the species.
Thinking fashion photographs through queer affect theory
Authors: Filippello Roberto 
Published: June 2018

Abstract
In this article, I suggest that the commonly used approaches to the study of fashion photographs could be fruitfully enriched by juxtaposing them with affect theory. I conduct a theoretical investigation of the benefits that affect theory, and in particular the strand articulated by queer theorists, may bring to the reflections on fashion photographs. I do so in a twofold way: by intertwining traditional visual analysis with an affective reading grounded in corporeal experience; and by illustrating how the queer affects circulating in fashion photographs might foreground issues of gender and sexuality and unfold possibilities of queer attachment. Two very different case studies, a photo spread by Corinne Day for The Face and the Gucci Pre-Fall 2016 advertising campaign, are chosen to explore how a specific affective register, i.e. ‘flat affect’, embedded in the images, might open up possibilities for envisioning queer aesthetic futures.