bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aluminum corrosion inhibition by cefixime drug: experimental and DFT studies
Authors: Diki N’guessan Yao Silvere , Gbassi Gildas K. , Ouedraogo Augustin , Berte Mohamed , Trokourey Albert 
Published: August 2018

Corrosion inhibition of aluminum in 1 M HCl by cefixime drug has been studied at 298-318 K using mass loss, Tafel polarization (at 298 K) and quantum chemical methods based on density functional theory (DFT) calculations. The results showed that inhibition efficiency increases up to 90.41 % with increase of the inhibitor concentration from 0.02 to 2 mM, but decreases with a rise of the solution temperature. Adsorption of cefixime molecules on the corroding aluminum surface obeys Langmuir adsorption isotherm and occurs spontaneously mostly through a physisorption process. The activation energy (Ea) as well as other thermodynamic parameters of the inhibition process are calculated and discussed. Potentiodynamic polarization data revealed that cefixime acts as mixed-type inhibitor and pointed out an agreement with mass loss results. Surface analysis is performed using scanning electron microscopy (SEM) which confirmed existence of a protective film of inhibitor molecules on the aluminum surface. In addition, global and local reactivity parameters of the studied molecule are analyzed and discussed. The computed results are found in agreement with experimental data.
Dry Eye After Phacoemulsification
Authors: Dhawan Munish , Kaur Gagandeep , Singh S.P. 
Published: August 2018

Background:-
Dry eye is a multifactorial, heterogeneous disorder of the preocular tear film because of tear deficiency or excessive tear evaporation which causes symptoms of ocular discomfort. Many patients who have undergone cataract surgery have complained of dry eye and symptoms of irritation postoperatively. The aim of this study was to evaluate the incidence and severity pattern of dry eye after phacoemulsification.

Design:-
Prospective study.

Materials & Methods:-
100 uncomplicated cataract patients coming to Guru Gobind Singh Medical College and Hospital, Faridkot were selected for study. Dry eye incidence and pattern were analyzed preoperatively and at days 1, 7, 30 and 90 after phacoemulsification using (1) Ocular Surface Disease Index (OSDI) questionnaire, (2) tear break up time (TBUT), (3) rose bengal staining, (4) Schirmer I test without anesthesia and (5) Schirmer 2 test with anesthesia. Data was evaluated by student T test.

Results:-
Seven days after phacoemulsification, the incidence of dry eye was 11%. The severity of dry eye peaked seven days post-phacoemulsification and was measured by OSDI questionnaire and all four clinical tests. Within 30 days and 3 months post-surgery, both the symptoms and signs showed rapid and gradual improvements respectively.

Conclusions:-
The incidence of dry eye after phacoemulsification was 11%. Symptoms and signs of dry eye occurred as early as seven days post-phacoemulsification and the severity pattern improved over time. We recommend that ophthalmologists should evaluate patients both before and after phacoemulsification to prevent further damage to the ocular surface and manage the patient promptly and effectively so that the patient does not have a poor quality of life and vision due to dry eye syndrome.
Rh(III)‐Catalyzed Selective C8−H Acylmethylation of Quinoline N‐Oxides
Authors: You Chang , Pi Chao , Wu Yangjie , Cui Xiuling 
Published: August 2018

AbstractA highly efficient Rh‐catalyzed regioselective C8−H acylmethylation of quinoline N‐oxides with sulfoxonium ylides using N‐oxide as the directing group under air atmosphere has been developed. This transformation has the generality of a broad scope of substrates, avoids external oxidants, and provides an efficient protocol to C8−H acylmethylated quinolines.magnified image
Rolled‐Up Self‐Assembly of Compact Magnetic Inductors, Transformers, and Resonators
Authors: Karnaushenko Dmitriy D. , Karnaushenko Daniil , Grafe Hans‐Joachim , Kataev Vladislav , Büchner Bernd , Schmidt Oliver G. 
Published: August 2018

Abstract3D self‐assembly of lithographically patterned ultrathin films opens a path to manufacture microelectronic architectures with functionalities and integration schemes not accessible by conventional 2D technologies. Among other microelectronic components, inductances, transformers, antennas, and resonators often rely on 3D configurations and interactions with electromagnetic fields requiring exponential fabrication efforts when downscaled to the micrometer range. Here, the controlled self‐assembly of functional structures is demonstrated. By rolling up ultrathin films into cylindrically shaped microelectronic devices, electromagnetic resonators, inductive and mutually coupled coils are realized. Electrical performance of these devices is improved purely by transformation of a planar into a cylindrical geometry. This is accompanied by an overall downscaling of the device footprint area by more than 50 times. Application of compact self‐assembled microstructures has significant impact on electronics, reducing size, fabrication efforts, and offering a wealth of new features in devices by 3D shaping.
Nasal polyp fibroblasts modulate epithelial characteristics via Wnt signaling
Authors: Dobzanski Alex , Khalil Syed Muaz , Lane Andrew P. 
Published: August 2018

BackgroundWhile essential to the normal differentiation of ciliated airway epithelial cells, upregulated Wnt signaling in chronic rhinosinusitis with nasal polyps (CRSwNP) has been proposed to result in abnormal epithelial morphology and dysfunctional mucociliary clearance. The mechanism of epithelial Wnt signaling dysregulation in CRSwNP is unknown, and importantly cellular sources of Wnt ligands in CRSwNP have not yet been investigated.MethodsHuman sinonasal epithelial cells (hSNECs) and human sinonasal fibroblasts (hSNFs) were collected from 34 human subjects (25 control and 9 CRSwNP) and differentiated as primary air‐liquid interface (ALI) and organoid co‐cultures. hSNECs were isolated to the apical compartment of the transwell and hSNFs were isolated to the basolateral compartment. After 21 days of ALI culture, ciliary expression and sinonasal epithelial morphology were examined by immunohistochemistry (IHC) and quantitative real‐time polymerase chain reaction (qRT‐PCR). An organoid model was used to evaluate proliferation of basal cells in presence of hSNFs.ResultsEpithelial cells co‐cultured with CRSwNP‐hSNFs revealed significantly decreased ciliated cells, altered epithelial cell morphology, and increased colony forming efficiency compared to epithelial cells co‐cultured with control‐hSNFs. CRSwNP‐hSNFs showed significantly higher messenger RNA (mRNA) expression of canonical WNT3A. A Wnt agonist, CHIR99021, replicated CRSwNP‐hSNF co‐cultures, and treatment with the Wnt inhibitor IWP2 prevented abnormal morphologies.ConclusionThese results suggest that abnormal interactions between epithelial cells and fibroblasts may contribute to CRSwNP pathogenesis and supports the concept that dysregulated Wnt signaling contributes impairment to epithelial function in CRSwNP.
Polynesian Deforestation of New Zealand: A Preliminary Synthesis
Authors: McGlone M. S. 
Published: August 2018

In olden times our islands were covered with forest growth; the only open spaces were sterile places whereon nothing would grow. When Kupe and other early immigrants arrived here they lit fires at all places whereat they landed, and so much forest was destroyed, also the moa perished in those fires.Maori tradition related to Best (1942:2).
Bayesian l0‐regularized least squares
Authors: Polson Nicholas G. , Sun Lei 
Published: August 2018

AbstractBayesian l0‐regularized least squares is a variable selection technique for high‐dimensional predictors. The challenge is optimizing a nonconvex objective function via search over model space consisting of all possible predictor combinations. Spike‐and‐slab (aka Bernoulli‐Gaussian) priors are the gold standard for Bayesian variable selection, with a caveat of computational speed and scalability. Single best replacement (SBR) provides a fast scalable alternative. We provide a link between Bayesian regularization and proximal updating, which provides an equivalence between finding a posterior mode and a posterior mean with a different regularization prior. This allows us to use SBR to find the spike‐and‐slab estimator. To illustrate our methodology, we provide simulation evidence and a real data example on the statistical properties and computational efficiency of SBR versus direct posterior sampling using spike‐and‐slab priors. Finally, we conclude with directions for future research.
Algorithm based on modified angle‐based outlier factor for open‐set classification of text documents
Authors: Walkowiak Tomasz , Datko Szymon , Maciejewski Henryk 
Published: August 2018

AbstractThis paper presents a new method of open‐set classification of text documents, with respect to subject areas. Standard (closed‐set) approaches to text classification involve training classifiers on annotated text corpora, representing a fixed number of subject areas. Such classifiers assign a new document with unknown annotation to one of the trained classes, even if the new document is not related to any class.We propose a two‐step procedure for open‐set classification. We first use a closed‐set classifier to assign a new document to one of the known classes. Then, we evaluate the (dis)similarity between the document and the chosen class using a novel criterion of outlierness named interquartile ranged angle‐based outlierness factors, which we find effective in high‐dimensional data. Based on this, we can avoid spurious assignment of documents to unrelated subject classes.We demonstrate the feasibility of this procedure in the task of subject classification of a collection of Wikipedia documents. As compared to the standard closed‐set approach, our open‐set classifier realizes significantly better precision with only small decrease of the recall measure observed in recognition of the tested classes.
„Außenliegende Wandtemperierung”
Authors: Schmidt Christoph , Altgeld Horst , Groß Bodo , Luther Gerhard , Maas Stefan , Scholzen Frank 
Published: August 2018

AbstractIm Rahmen der Forschungsprojekte „LEXU” und „LEXU II” der IZES gGmbH wurde eine außenliegende Wandtemperierung (aWT) entwickelt und erprobt. Bei der außenliegenden Wandtemperierung handelt es sich um eine niederexergetische Flächentemperierung, die zwischen Bestandswand und neuem Wärmedämmverbundsystem (WDVS) aufgebracht wird. Es ist somit ein Sonderfall eines thermoaktiven Bauteilsystems (TABS), mit Fokus auf dem niederexergetischen Ansatz und mit der Möglichkeit einer minimalinvasiven thermischen Sanierung „von außen”. Erweitert man den Wandaufbau um einen Luftspalt zwischen dem Temperierungssystem und dem WDVS, so kann die aWT zu einer außenliegenden Lufttemperierung (aLT) erweitert werden. Neben der Erarbeitung der theoretischen Grundlagen und von Simulationsmöglichkeiten, werden beide Systeme aktuell anhand eines Demonstrationsobjektes umgesetzt. Der Fokus der Veröffentlichung liegt auf der Umsetzung der Feldtestfläche für die aWT. Inhaltlich baut diese Veröffentlichung auf den theoretischen Betrachtungen und den Kennwerten aus dem ersten Teil zu der Thematik in der Ausgabe Bauphysik 4/2017 auf.
AKTIVkrankenhaus – Modernisierungsstrategie für ein klimaneutrales Krankenhausareal
Authors: Fahrion Marc‐Steffen , Draeger Susan , Sinn Michel , Altinisik Leman , Sobek Werner 
Published: August 2018

AbstractDie Waldkliniken im thüringischen Eisenberg haben als erstes Krankenhaus das Ziel, ihren Gebäudebestand sowie die geplanten Neubauten durch den Zubau erneuerbarer Energien und eine intelligente Verbrauchssteuerung in naher Zukunft klimaneutral zu versorgen und somit den von Werner Sobek entwickelten Aktivhaus‐Standard für ein gesamtes Krankenhausareal zu erfüllen. Im Rahmen einer durch das Thüringer Ministerium für Umwelt, Energie und Naturschutz sowie den Europäischen Fonds für regionale Entwicklung (EFRE) geförderten Studie wurde eine entsprechende Modernisierungsstrategie entwickelt. Infolge des aktuell noch sehr hohen Energieverbrauchs wurden zunächst Effizienzpotenziale im Bestand analysiert. Im Anschluss fand eine Untersuchung der am Standort erschließbaren regenerativen Energiequellen statt. Darauf aufbauend wurden ein kurzfristig umsetzbares Energiekonzept sowie eine mittelfristige Modernisierungsstrategie entwickelt. Diese erlaubt es, bis zum Ende der 2040er Jahre ein AKTIVkrankenhaus zu realisieren und darüber hinaus sogar am Regelenergiemarkt teilzunehmen und somit die Energiewende überregional zu unterstützen.
Molecular Simulation‐Assisted Solvent Selection for Separation of 1,2,4‐Trimethylbenzene
Authors: Cho Jung Ho , Kim Young Han 
Published: August 2018

AbstractExtractive distillation is an alternative for processes where normal distillation is difficult, such as separation of close‐boiling mixtures, but solvent selection for distillation is laborious, and its selection pool is narrow. An innovative selection process using molecular simulation is proposed, and the performance of the selected solvent, 1,2,4‐trichlorobenzene, for the separation of 1,2,4‐trimethylbenzene from a C9 mixture is reviewed. The proposed process requires less investment and leads to lower operating expenses than the conventional two‐column process. The computed vapor‐liquid equilibrium determined from the molecular simulation is close to the HYSYS estimation in two ternary systems.
Development and validation of the autotransplanted maxillary canine radiological index
Authors: Grisar Koenraad , Vanpoecke Jasper , Raes Margot , Albdour Emad Ali , Willems Guy , Politis Constantinus , Jacobs Reinhilde 
Published: August 2018

AbstractThe purpose of this study was to propose and validate an index evaluating 2D and 3D radiographic variables of autotransplanted maxillary canines. Setting and sample population are from the Department of Oral and Maxillofacial Surgery at University Hospitals Leuven. Eight oral‐maxillofacial surgeons rated 12 autotransplanted maxillary canines and adjacent bone using 11 rating variables. A new autotransplanted maxillary canine radiological index (AMCRI) was proposed. It consisted of 11 variables. These variables were based on 2D (intraoral) and 3D Cone Beam Computed Tomography (CBCT) radiographs. Intraclass correlation coefficient (ICC) and Fleiss's kappa statistics were performed to analyze intrarater and interrater agreement. Considering cumulative assessment of the AMCRI, the mean ICC value for the interrater agreement of the eight examiners was 0.94, representing an excellent agreement. Intrarater agreement was 0.91. The AMCRI is an objective tool in rating radiological outcome of autotransplanted canines and adjacent bone, when compared with the contralateral canine.
Food additives and bioactive substances from in vitro systems of edible plants from the Balkan peninsula
Authors: Vrancheva Radka , Ivanov Ivan , Aneva Ina , Stoyanova Magdalena , Pavlov Atanas 
Published: August 2018

AbstractDuring the last few years there is an increasing demand to the natural biologically active compounds. According to the World Health Organization (WHO) about 11% of the conventional medicines are of plant origin. Nowadays, plant biotechnologies are modern and reliable tool for producing valuable bioactive compounds. Recently, the potential of plant cells as foods also was confirmed. The advantages of plant in vitro systems over the intact plants are well known: growing under controlled and optimized laboratory conditions; independence of climatic and soil differences; preservation of rare and endangered plant species; cultivation in diverse bioreactor systems for increasing production yields of target metabolites.There have been developed many in vitro systems for production of various plant bioactive compounds with potential application in food industries. But potential for industrial implementation of this technology depends on solving problems with the scale‐up of bioreactor cultivation, development of additional approaches for improving/modification of bioactivities of the target plant secondary metabolites, and to find way to exclude or replace in the culture media the carcinogenic plant growth regulator 2,4‐dichlorophenoxyacetic acid (2,4‐D) with its safety analogs, such as α‐naphtaleneacetic acid (NAA) and/or indole‐3‐butyric acid (IBA).The aim of the current mini review is to summarize information about different in vitro systems of edible plants from the Balkan Peninsula with potential for producing food additives and biologically active substances and to describe prospects for successful industrial implementation of this technology.
Incorporating Variability and Reuse into System Architecture Models – Principles and Challenges
Authors: Malone Robert , Friedland Brittany , Herrold John , Houde Ronald 
Published: August 2018

AbstractGreat economies are achieved in the design, production and support of corporate Product Lines if available features and components can be shared across Products and across Product Lines. Incorporation and effective management of Product variability and component reuse within System Architecture models can improve the chances of successfully designing and deploying Product Lines. This paper introduces some principles for incorporating feature‐based variability and reuse within System Architecture models, and also some challenges that must be overcome to allow the effective management of Product Line design models.
What Can You Learn About Systems Engineering by Building a Lego™ Car?
Authors: Hahn Heidi Ann 
Published: August 2018

AbstractLos Alamos National Laboratory's (LANL's) Future Female Leaders in Engineering (FFLIE) Program brings female engineering undergraduate students to the Laboratory for summer internships, which include a technical work assignment and a specialized eight‐week long professional development course. During their first year, FFLIE students receive training on LANL's Mission Assurance (MA) Program, which involves the integrated application of systems engineering (SE), project management (PM), and engineering quality and rigor (QA) to ensure mission success. The instruction is organized around the system development project life cycle and emphasizes activities and artifacts associated with the various life cycle phases. A home improvement project (adapted from Braakhuis, Janssen, Koudenburg, de Liefde, Malotaux, Rens, and Stevenson, 2010) is used in a series of table‐top exercises throughout to illustrate various points. The training culminates with a project – building a car for a Lego™ Derby race – on which the students exercise the skills they have just learned in the classroom instruction. This paper briefly reviews the instructional content, with an emphasis on the activities and artifacts exercised in the Derby project; provides lessons learned; and concludes that there's a lot one can learn about SE by building a Lego™ Derby car if the experience is properly structured! Overviews of FFLIE students’ learnings about requirements, measures of performance, trade studies, and verification and validation are provided.
The Implementation of a Business Intelligence Platform to Leverage the Army Logistics Support Command's Balanced Scorecard – A Case Study
Authors: Rodríguez Raúl , Díaz‐Osto Pedro , Sols Alberto 
Published: August 2018

AbstractMany complex organizations struggle to optimize the use of their assets and resources. The Logistics Support Command of the Spanish Army was aware, about a decade ago, of a number of inefficiencies that had a negative influence on the effectiveness of the weapon systems that it had to sustain in their operational lives. In order to improve the management of its allocated resources, it decided to develop and implement a balanced scorecard and a business intelligence platform. The job was performed with the support of ISDEFE (Engineering Systems for the Defence of Spain) the systems engineering firm of the Ministry of Defence. The systems approach led to a successful implementation of the needed platform, which substantially enhanced the effectiveness and efficiency of the Logistics Support Command. This paper shows what was done, and how. This case study of applied systems engineering enables the issuing of a number of recommendations for organizations that plan to develop similar business intelligence platforms, as a mechanism to becoming more competent and successful at the managing of their resources.
The Systems Engineering Incompetency Framework
Authors: Pickard Andrew C , Beasley Richard , Nolan Andy J 
Published: August 2018

AbstractThe INCOSE Competency Working Group has invested significant effort in defining a Systems Engineering Competency Framework. This is important in that it allows Engineers to assess their level of competence in the different Systems Engineering skills and see where further training or on‐the‐job experience may help them become more effective Systems Engineers. The assumption is that competency starts at zero and improves with experience and training. This paper looks at the opposite side of the coin; what happens if a competence is not just absent, but if a reverse “incompetence” is present. Does this spell disaster for a program or for development of an effective product? Is it possible to train someone in an incompetency? What can Engineers do to avoid developing a “Systems Engineering Incompetency”?
Informing the delineation of input uncertainty space in exploratory modelling using a heuristic approach
Authors: Moallemi Enayat A. , Elsawah Sondoss , Ryan Michael J. 
Published: August 2018

AbstractExploratory modelling is an emerging approach which can address the challenge of model‐based decision making in dealing with input model uncertainties. Exploratory modelling samples from an input uncertainty space and generates extensive computational experiments to analyse possible model behaviours in an output solution space. The way that the input uncertainty space is delineated influences the results of exploratory modelling and its computational cost. In this article, we show the statistical significance of the implication of the size of an input uncertainty space on the resulted output solution space. We also propose a heuristic approach which informs the delineation of input uncertainties by screening the relevant model behaviour in the solution space. An illustrative example of an aircraft fleet management system is used to demonstrate the implementation of our approach in practice. We conclude that the delineation of input uncertainty space can be a way to control simulations in exploratory modelling and to enhance the efficiency of the exploration process and the confidence of the final results.
Utilization of Goal Function Trees for Robust Requirements Definition
Authors: Gethers Marc , Thomas Dale 
Published: August 2018

AbstractThis paper describes the implementation of the Goal Function Tree (GFT) for an Unmanned Aerial Vehicle (UAV) in a Systems Modeling Language (SysML) environment which tracks nominal and off nominal goals for a successful flight of a UAV. The utility of the GFT enables the traceability of the system's goals and requirements to perform a successful mission scenario. Definition of nominal goals reduces ambiguity about mission success and can be followed more easily by the customer. Furthermore, the Goal Function Tree can also track and implement corrections if the measurements for success are deviating through the use of off nominal functions. The GFT's off nominal functions create a new set of functions and goals that attempt to mitigate a failing attribute instead of the other methods that only defined failure. This methodology creates a set of procedures for an operator or system when action is needed, thereby identifying more robust requirements as compared to traditional requirements development based only on nominal mission scenarios. The advantage of the SysML environment enables the legible traceability of the overlapping of goals of various structural and behavioral system objects, the execution of functions, and implementation of stereotypes which classifies the interactions between objects.