bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED: Long noncoding RNA UFC1 is activated by E2F1 and exerts oncogenic properties by functioning as a ceRNA of FOXP3
Authors: Xi Jie , Feng Jing , Zeng Saitian , Huang Ping 
Published: May 2018

AbstractCervical cancer is one of the most common gynecologic cancers around the world. Long noncoding RNAs (lncRNAs) are considered to be important regulators of some biological processes. Recently, it has been reported that linc‐UFC1 is a putative oncogene in some cancers. However, the functional roles of linc‐UFC1 have not been investigated in cervical cancer. Here, it was demonstrated that linc‐UFC1 expression was significantly increased in cervical cancer tissues, and its overexpression was associated with the poor survival of patients with cervical cancer. Loss‐of‐function assays indicated that linc‐UFC1 exerted as an oncogene because it promoted the growth and metastasis of cervical cancer cells in vitro and in vivo. Mechanistic investigations revealed that linc‐UFC1 upregulated FOXP3 expression through competitively binding miR‐34a. Finally, luciferase reporter and chromatin immunoprecipitation (ChIP) assays provided evidence that E2F1 could directly bind to the linc‐UFC1 promoter region and enhance its transcription. Taken together, our findings indicate that the linc‐UFC1 expression signature may serve as a novel biomarker for the diagnosis and prognosis of cervical cancer, and it is also highlighted that the E2F1‐linc‐UFC1/miR‐34a/FOXP3 axis may be a potentially therapeutic target of cervical cancer.
Genetically determined height was associated with lung cancer risk in East Asian population
Authors: Wang Lu , Huang Mingtao , Ding Hui , Jin Guangfu , Chen Liang , Chen Feng , Shen Hongbing 
Published: May 2018

AbstractThe association between adult height and risk of lung cancer has been investigated by epidemiology studies, but the results are inconsistent. Mendelian randomization (MR) analyses with individual‐level data from two genome‐wide association studies, including a total of 7127 lung cancer cases and 6818 controls, were carried out to explore whether adult height is causally associated with risk of lung cancer. A weighted genetic risk score (wGRS) was created based on genotypes of 101 known height‐associated genetic variants. Association between the wGRS and risk of lung cancer was analyzed by logistic regression for each study separately. The combined effect was calculated using fixed effect meta‐analysis. MR analyses showed that increased risk of lung cancer (OR = 1.19, 95%CI: 1.05‐1.35, P = 0.006) associated with taller genetically determined height. Compared with individuals in the lowest tertile of the height‐associated wGRS, those in the highest tertile had 1.10‐fold (95% CI: 1.01‐1.20) increased risk of developing lung cancer. Sensitivity analyses excluding BMI‐associated genetic variants demonstrated consistent association. Our study suggested that genetically taller height was associated with increased risk of lung cancer in East Asian population, indicating that increasing height may have a causal role in lung cancer carcinogenesis.
Ventriculomegaly and cerebellar hypoplasia in a neonate with interstitial 11q 24 deletion in Jacobsen syndrome region
Authors: Puvabanditsin Surasak , Chen Charlotte Wang , Botwinick Marissa , Hussein Karen , Mariduena Joseph , Mehta Rajeev 
Published: May 2018

Key Clinical MessageJacobsen syndrome (JS) is a rare contiguous gene disorder caused by partial deletion of the distal part of the long arm of chromosome 11 ranging in size from 7 to 20 Mb. We report a term male neonate with an interstitial deletion of about 12.3 megabase (Mb) of chromosome 11q24.1qter. Our case is the first reported newborn patient with 11q24 deletion.
Reversible manifestations of extraparenchymal neurocysticercosis
Authors: Campos Edison M. , Raslau Flavius D. , Salinas Robert , Di Capua Daniela , Slevin John T. , Villamar Mauricio F. 
Published: May 2018

Key Clinical MessageMovement disorders are uncommon manifestations of neurocysticercosis. When present, most are secondary to parenchymal lesions in the basal ganglia. Rarely, movement disorders can occur in racemose/extraparenchymal neurocysticercosis, an aggressive variant frequently associated with cerebrospinal fluid outflow obstruction and hydrocephalus. Appropriate treatment can reverse neurological manifestations.
Closing the Gap in Formic Acid Reforming
Authors: Zhao Long , Lolli Giulio , Wolf Aurel , Mleczko Leslaw 
Published: May 2018

AbstractFormic acid (FA) has the potential to become the renewable platform chemical in the future chemical industry. To achieve this potential, FA and its conversion processes should be competitive with the traditional platform chemicals and processes. A reaction kinetic study and a process conceptual design of FA reforming to CO are conducted. The optimized process is characteristic of high conversion, selectivity, and overall exergy efficiency, which outperforms the conventional steam methane reformer that is limited by its thermodynamic equilibrium and consequently displays lower overall exergy efficiency. CO generated from FA reforming can be used as the component of ‘renewable syngas' that seems to be attractive in consideration of some important industrial aspects.
Engineered Metalloenzymes with Non‐Canonical Coordination Environments
Authors: Hayashi Takahiro , Hilvert Donald , Green Anthony P. 
Published: May 2018

AbstractNature employs a limited number of genetically encoded, metal‐coordinating residues to create metalloenzymes with diverse structures and functions. Engineered components of the cellular translation machinery can now be exploited to encode non‐canonical ligands with user‐defined electronic and structural properties. This ability to install “chemically programmed” ligands into proteins can provide powerful chemical probes of metalloenzyme mechanism and presents excellent opportunities to create metalloprotein catalysts with augmented properties and novel activities. In this Concept article, we provide an overview of several recent studies describing the creation of engineered metalloenzymes with interesting catalytic properties, and reveal how characterization of these systems has advanced our understanding of nature's bioinorganic mechanisms. We also highlight how powerful laboratory evolution protocols can be readily adapted to allow optimization of metalloenzymes with non‐canonical ligands. This approach combines beneficial features of small molecule and protein catalysis by allowing the installation of a greater variety of local metal coordination environments into evolvable protein scaffolds, and holds great promise for the future creation of powerful metalloprotein catalysts for a host of synthetically valuable transformations.
Metal‐Organic Frameworks Based on Multicenter‐Bonded [MI]8 (M=Mn, Zn) Clusters with Cubic Aromaticity
Authors: Hu Huan‐Cheng , Zhao Bin 
Published: May 2018

AbstractA new concept for constructing metal‐organic frameworks (MOFs) based on multicenter‐bonded [MI]8 (M=Mn, Zn) clusters with cubic aromaticity is discussed. In principle, intermolecular/intramolecular hydrogen‐bonding, π–π stacking, coordinated covalent bonding and ionic bonding usually account for the structures of MOFs, and multicentered bonds generally exist in cation, anion, neutral and zwitterionic radicals, while rarely appear in MOFs. Meanwhile, aromaticity became one of the most vexing yet fascinating key concepts in chemistry since the proposition of the structure of benzene molecule in 1865. In this context, this concept article exhibits the preparation, structures, characterization methods, theoretical analysis of current research for MOFs which feature with multicentered bonding [MI]8 (M=Mn, Zn) cluster with cubic aromaticity, followed by their fluorescence probe and magnetic properties are also summarized. Finally, prospective outlook in this field is given.
A Strategy of “Self‐Isolated Enhanced Emission” to Achieve Highly Emissive Dual‐State Emission for Organic Luminescent Materials
Authors: Xu Yanzi , Ren Lin , Dang Dongfeng , Zhi Ying , Wang Xiaochi , Meng Lingjie 
Published: May 2018

AbstractCurrently, the commonly developed organic luminescent materials (OLMs) usually exhibit poor luminescent performance in aggregated solid states compared with their well‐dissolved solution states, making it a tough goal to achieve the highly emissive dual‐state emission. To overcome this limitation, a “self‐isolated enhanced emission” (SIEE) strategy through flexible alkyl chains to suppress the emission‐quenched π–π stacking in solids is proposed here and, based on this guideline, remarkable emission efficiency with photoluminescence quantum yields up to 99.72 % in solution and 77.46 % in the solid state are achieved for the SIEE constructed DBBT‐C8, which is then successfully used in solid‐state displays and data encryption.
Double‐layered dual‐tuned RF coil using frequency‐selectable PIN‐diode control at 7‐T MRI
Authors: Han Sang‐Doc , Heo Phil , Kim Han‐Joong , Song Hyunwoo , Kim Donghyuk , Seo Jeung‐Hoon , Ryu Yeunchul , Noh Young , Kim Kyoung‐Nam 
Published: May 2018

AbstractThis article presents a dual‐tuned (DT) radiofrequency (RF) coil for signal acquisition of 2 nuclei, namely, hydrogen (1H) and sodium (23Na), in the ultra‐high magnetic field of a 7‐T magnetic resonance imaging (MRI) system. The double‐layered dual‐tuned (DLDT) coil comprises a 2‐loop coil configuration per single‐pair geometry, with the 1H and 23Na coils being located on the outside and inside, respectively. The 1H and 23Na single‐pair elements are tuned to resonance frequencies of 297.20 and 78.61 MHz, respectively. The single‐pair geometry of the DLDT coil is extended to an 8‐pair configuration to cover the human head, and the operation mode is transmission/reception (Tx/Rx). The 8‐pair DLDT Tx/Rx coil array is designed with a non‐overlapped single pair between the 1H coil elements for geometric decoupling, and capacitive decoupling is implemented to minimize the mutual inductance coupling. The 2 resonance frequencies are fed through a single RF port to a common matching board, and each frequency is selected using the voltages at both ends of a PIN diode. Through use of the PIN diode in the DLDT coil configuration, with a voltage drop at both ends, different resonance frequencies can be selected for each coil element in accordance with the diode ON/OFF state. The experiments conducted showed that the proposed DLDT coil is effective in acquiring signals of 1H and 23Na in the MRI system.
Self‐Assembly of 1D Helical Nanostructures into Higher Order Chiral Nanostructures in Supramolecular Systems
Authors: Jiang Hejin , Zhang Li , Liu Minghua 
Published: May 2018

AbstractChirality and hierarchy are two important aspects of biological systems. Investigation of the hierarchical self‐assembly of chiral supramolecular nanostructures leads not only to biomimics but also provides deep understanding of the self‐assembly and function in biological systems. While it is generally well‐known how small molecules can self‐assemble into nanostructures like chiral nanofibers, nanobelts, nanotubes and nanotwists, it is still less frequently investigated how these nanostructures can be further assembled into higher ordered chiral nanostructures. In this review, we mainly focus on how these 1D helical nanostructure can be further assembled into higher ordered or complex chiral nano/microstructures such as nanospirals, super‐nanohelices, helical nanotubes, nanoflowers, toroids, microflowers, microtubular flowers and dendritic chiral nanotwists. Moreover, some applications including asymmetric catalysis, cell adhesion, chiral optics and chiral recognition based on these nanostructures are discussed.
A real‐time bus‐subway transfer scheme recommendation systems
Authors: Zhang Jun , Tu Lai , Zhang Fan , Huang Benxiong , Liu Jin 
Published: May 2018

SummaryBus and subway service is an important public transportation. Besides the major goal of carrying passengers around, providing accurate and reliable travel information for passengers is also an important business consideration. The route and its traveling time can directly affect the number of people choosing the line. Traditional approaches to obtain route and its traveling time rely on historical experience, which are both non‐scalable and incomplete. The wide adoptions of On Board Units (OBUs) in public transportation provide new opportunities. In this paper, we associate bus GPS data with station locations to derive the traveling time between two stations and make a short forecast. To our best knowledge, this is the first paper that utilizes real‐time bus GPS data and subway arrival station data to design route and give its traveling time for a passenger.
Thermally Activated Self‐metalation of Carboxy‐functionalized Porphyrin Films on MgO Nanocubes
Authors: Kollhoff Fabian , Schneider Johannes , Berger Thomas , Diwald Oliver , Libuda Jörg 
Published: May 2018

AbstractWe investigated the adsorption of different free‐base carboxyl‐functionalized porphyrins, 5,10,15,20‐tetrakis(4‐carboxyphenyl)‐21,23H‐porphyrin (2H‐TCPP) and 5(4‐carboxyphenyl)‐10,15,20‐triphenyl‐21,23H‐porphyrin (2H‐MCTPP), on MgO nanocubes combining IR, UV/Vis and photoluminescence emission spectroscopy. The thermal behavior of the films was monitored in‐situ during annealing. Both porphyrins bind to the nanocubes via one and two acid groups respectively, yielding monolayer films consisting of tilted molecules. For 2H‐TCPP, two acid groups remain free and give rise to a characteristic IR band. Self‐assembly in a tilted adsorbate layer suppresses metalation at room temperature, in contrast to non‐functionalized 2H‐TPP, which adsorbs flat‐lying. Upon heating, 2H‐MCTPP undergoes full metalation at temperatures below 280 °C, whereas 2H‐TCPP does not metalate at all. The hindered metalation reaction is attributed to the rigidity of the adsorbate film preventing complexation. Our results show that the properties of porphyrin films on oxides can be tuned in a wide range via the position and arrangement of carboxyl anchoring groups.
Nonlinear Optical and Laser Damage Properties of KDP Crystal with Trace Impurities in Bulk
Authors: Wen Jibin , Geng Feng , Wang Fengrui , Huang Jin , Jiang Xiaodong , Deng Qinghua , Cao Linhong 
Published: May 2018

AbstractSmall‐sized potassium dihydrogen phosphate (KDP) samples cut from the pyramid sector of a large KDP boule are observed to have different impurity content. The nonlinear absorption properties of two KDP samples containing different impurities are characterized by Z‐scan technique with picosecond laser at 355 nm wavelength. Reverse saturable absorption effects are found in samples, with nonlinear absorption coefficients of 7.35 × 10−2 cm GW−1 and 15.91 × 10−2 cm GW−1. The sample with more impurity contents exhibits stronger nonlinear absorption. Such behavior is considered to be a result of nonlinear energy coupling under 355 nm laser irradiation assisted by impurity defects. Nanosecond laser‐induced damage test at 355 nm of the two KDP samples is further investigated. The bulk damage thresholds of the two samples are 4.7 and 0.423 J cm−2 respectively, indicating that impurity‐induced nonlinear absorption might play an important role in laser‐induced damage processes.
One‐Step Lignocellulose Fractionation by using 2,5‐Furandicarboxylic Acid as a Biogenic and Recyclable Catalyst
Authors: Weidener Dennis , Klose Holger , Leitner Walter , Schurr Ulrich , Usadel Björn , Domínguez de María Pablo , Grande Philipp M. 
Published: May 2018

AbstractTo develop novel biorefinery concepts, the use of bio‐based catalysts and solvents must be aligned with the principles of green chemistry. In this context, biogenic 2,5‐furandicarboxylic acid (FDCA) is a very promising yet underused molecule with high potential for application as an acid catalyst, combining feasibility and sustainability with efficient and straightforward recovery. In this study, FDCA was evaluated as a catalyst in the recently developed OrganoCat pretreatment, a biphasic lignocellulose fractionation system. The catalyst was investigated for the efficient fractionation of the three main components—lignin, cellulose and noncellulosic sugars—with particular focus on the lignin quality, on the effect on enzymatic hydrolysis of the cellulosic residue, and on the noncellulosic sugar extraction. To address recovery of FDCA from the OrganoCat system, a method was developed, leading to the recovery of >97 % of FDCA with a spectroscopic purity of >99 %, maintaining full activity in consecutive runs.
The epidemiology of avian pox and interaction with avian malaria in Hawaiian forest birds
Authors: Samuel Michael D. , Woodworth Bethany L. , Atkinson Carter T. , Hart Patrick J. , LaPointe Dennis A. 
Published: May 2018

AbstractDespite the purported role of avian pox (Avipoxvirusspp.) in the decline of endemic Hawaiian birds, few studies have been conducted on the dynamics of this disease, its impact on free‐living avian populations, or its interactions with avian malaria (Plasmodium relictum). We conducted four longitudinal studies of 3–7 yr in length and used generalized linear models to evaluate cross‐sectional prevalence of active pox infection and individuals with healed deformities that had recovered from pox. Our goal was to understand how species, season, elevation, malaria infection, and other biological characteristics influenced pox infection in ʻApapane, Hawaiʻi ʻAmakihi, ʻIʻiwi, and Japanese White‐eye across low‐, mid‐, and high‐elevation forests on the island of Hawaiʻi. We also used multi‐state capture‐recapture (longitudinal) models to estimate pox infection rates, recovery rates, and potential pox‐related mortality. Pox infection rates were typically highest in low‐elevation forests, followed by mid‐elevation forests, and lowest in high‐elevation forests. We also found seasonal changes in pox prevalence throughout the annual cycle; typically increasing from spring through summer, peaking in fall, and declining in winter. These seasonal changes occurred in low‐ and mid‐elevation forests, but not in high elevations where pox infection was low. Seasonal and elevation patterns of pox infection are like those for avian malaria, strongly implicating mosquito vectors, rather than other biting arthropods or contact transmission, as the primary source of transmitting both diseases. Most native Hawaiian birds recovered from pox infection within 6 months; frequently without permanent lesions. Contrary to our expectations, we found no direct evidence that pox is a substantial mortality factor in any of the three native bird species we studied. Birds with chronic malaria infection were more likely to have both active pox infection and healed pox lesions suggesting a synergistic interaction that may influence the evolution of pox virulence. Because pox infection can be assessed visually, and birds have a high recovery rate, this disease may be a sensitive indicator of the seasonal and annual risk of transmission of malaria in Hawaiʻi.
Development of Highly Energy Densified Ink for 3D Printable Batteries
Authors: Park Sujin , Nenov Nenko S. , Ramachandran Arathi , Chung Kyeongwoon , Hoon Lee Sea , Yoo Jungjoon , Yeo Jeong‐gu , Bae Chang‐Jun 
Published: May 2018

AbstractNovel Li‐ion battery inks are integral elements to increase mechanical integrity and energy density of 3D printable batteries. Conventional battery inks have been limited to the Polyvinylidene fluoride (PVdF) and N‐methyl‐2 pyrrolidon (NMP) solvent that are unpleasant of long drying process and environmentally hazard solvent. As a novel Li‐ion battery ink for highly energy densified 3D printable batteries, we have developed acrylate‐based curable inks which demonstrate fast process, highly cross‐linked polymerization and more eco‐friend suspension. Here, we report a novel development of curable LIB ink with fundamental studies of rheology, curing behavior and electrochemical performances. The viscosity and activation energy of curable LIB inks are low and shear shinning behavior and 118.9 kJ/mol, respectively, which are appropriate for the extrusion 3D printer with nozzle radius of 0.75 mm and the speed of 5 mm/sec. Furthermore, electrochemical performance of capacity, oxidation peak and cycle retention is comparable to conventionally fabricated electrode.
Convergence of detection probability, computational gains, and asymptotic analysis of an algorithm for physical‐layer intrusion detection system
Authors: Yousaf Awais , Loan Asim , Babiceanu Radu F. , Maglaras Leandros , Yousaf Onaiza 
Published: May 2018

AbstractAsymptotic analysis of an algorithm is crucial for practical engineering design. It provides important information about the performance of an algorithm in terms of time complexity, space complexity, and input scale. Based on these performance metrics, engineers can utilize available resources for efficient implementation of the algorithm. In this paper, asymptotic analysis is performed for an algorithm designed for a physical‐layer intrusion detection system (PLIDS). The algorithm first solves Fredholm integral equation of the first kind using Tikhonov regularization. Then, the solution of this equation is used to design a criterion for detection of smart jamming attacks at physical‐layer of the TCP/IP protocol stack. The proposed detection criterion works in constant time. The asymptotic performance metric derived for PLIDS gives insights about its algorithmic behavior. Convergence of detection probability and computational gain of using PLIDS, over higher‐layer intrusion detection systems, are also explained. Finally, apart from asymptotic performance, the detection performance metrics of the PLIDS are also discussed.
Antiwrinkle and antimelanogenesis activity of the ethanol extracts of Lespedeza cuneata G. Don for development of the cosmeceutical ingredients
Authors: Lee Jongsung , Ji Jun , Park See‐Hyoung 
Published: May 2018

AbstractTo develop the ingredient with the cosmeceutical function, the antiwrinkle and antimelanogenesis effects of the ethanol extract of Lespedeza cuneata G. Don were investigated. DPPH radical scavenging activity was significantly increased with the extract of L. cuneata G. Don. Cell viability on CCD986Sk human fibroblast was also increased by the ethanol extract of L. cuneata G. Don. The inhibitory function of the extract of L. cuneata G. Don on collagenase, elastase, and tyrosinase was evaluated. Protein expression level of Claudin‐1, Occludin, and ZO‐1 was up‐regulated in HaCaT human keratinocyte by the extract of L. cuneata G. Don. In addition, the extract of L. cuneata G. Don inhibited melanin synthesis in B16F10 murine melanoma cells by decreasing MITF, TRP1, and TRP2 protein levels and increasing the phosphorylated Erk and Akt. Thus, these findings would be useful for developing the new cosmeceutical formulations based on the extract of L. cuneata G. Don.