bluuebunny/crossref_metadata_2025_split huggingface dataset:
Launching Austria’s One Health network: paving the way for transdisciplinary collaborations
Authors: Desvars-Larrive Amélie , Burger Pamela , Khol Johannes Lorenz , Posautz Annika , Schernhammer Eva , Kutalek Ruth , Puspitarani Gavrila Amadea , Schlippe Justicia Lia , Springer David Niklas , Ernst Damien , Sohm Cynthia , Pontel de Almeida Anna , Schobesberger Hermann , Knauf Sascha , Walzer Chris 
Published: October 2024

AbstractIn the post-COVID-19 era, stakeholders, including policymakers, funders, and the public, are increasingly seeking for a cross-sectoral systems-based approach to health risks extending beyond conventional measures. Anchored on three health pillars -human, animal, and environmental- One Health offers a promising framework to effectively address this demand. While some nations have already implemented national One Health strategic plans, European countries, in general, are lagging behind the global agenda. On 22 February 2024, an initiative was launched in Austria toward addressing this gap, bringing together multiple sectors and disciplines, marking the initial step in creating a national One Health network. The workshop emphasized the importance of enhancing One Health education and addressed key topics, such as incorporating the environmental pillar of One Health as well as socio-economic and cultural drivers to further our understanding of outbreaks, and establishing trusted communication channels, including data sharing, between disciplines and sectors. Identified challenges encompassed the need for more funding of transdisciplinary research. Opportunities for advancement include initiating local One Health projects and showcasing their positive impacts. Moving forward, efforts will focus on establishing a mature and globally connected One Health framework in Austria and supporting the integration of One Health aspects into education curricula, research programs, and policies.
Assessment of meniscal extrusion with ultrasonography: a systematic review and meta-analysis
Authors: Boksh Khalis , Shepherd Duncan E. T. , Espino Daniel M. , Shepherd Jenna , Ghosh Arijit , Aujla Randeep , Boutefnouchet Tarek 
Published: October 2024

Abstract
Background
Magnetic resonance imaging (MRI) is the imaging of choice for meniscal extrusion (ME). However, they may underappreciate the load-dependent changes of the meniscus. There is growing evidence that weight-bearing ultrasound (WB US) is more suitable, particularly in revealing occult extrusion. We therefore perform a systematic review and meta-analysis on the validity and reliability of US in diagnosing extrusion. Furthermore, we explored whether it detects differences in extrusion between loaded and unloaded positions and those with pathological (osteoarthritis and meniscal injury) and healthy knees.

Methods
The Cochrane Controlled Register of Trials, PubMed, Medline, and Embase were used to perform a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. Data pertaining to intra- and interrater reliability of US in measuring meniscal extrusion (ME), its correlation with magnetic resonance imaging (MRI), and head-to-head comparison of potential factors to influence ME were included [loading versus unloading position; osteoarthritis (OA) or pathological menisci (PM) versus healthy knees; mild versus moderate–severe knee OA]. Pooled data were analyzed by random or fixed-effects models.

Results
A total of 31 studies were included. Intraclass correlation coefficients (ICC) for intra- and interrater reliability were minimum 0.94 and 0.91, respectively. The correlation between US and MRI was (r = 0.76). US detected ME to be greater in the loaded position in all knees (healthy, p < 0.00001; OA, p < 0.00001; PM, p = 0.02). In all positions, US detected greater extrusion in OA (p < 0.0003) and PM knees (p = 0.006) compared with healthy controls. Furthermore, US revealed greater extrusion in moderate–severe OA knees (p < 0.00001).

Conclusions
This systematic review suggests ultrasonography can play an important role in the measurement of meniscal extrusion, with results comparable to that of MRI. However, to what extent it can differentiate between physiological and pathological extrusion requires further investigation, with an absolute cutoff value yet to be determined. Nevertheless, it is an appropriate investigation to track the progression of disease in those with meniscal pathologies or osteoarthritis. Furthermore, it is a feasible investigation to evaluate the meniscal function following surgery.
Level of evidence: IV, Systematic review of level III–IV evidence.
Association of MnSOD (rs4880) and GPx1 (rs1050450) with diabetic nephropathy: a meta-analysis
Authors: Begum Farhana , Lakshmanan Karpagavel 
Published: October 2024

Abstract
Background
Microvascular complications of diabetes including retinopathy, nephropathy, and neuropathy are those long-term complications that affect small blood vessels. Diabetic nephropathy (DN) is characterized by persistent microalbuminuria. A meta-analysis of case–control studies aims to examine the relationship between MnSOD (rs4880) and GPx1 (rs1050450) and the risk of DN.

Methods
Various databases such as Web of Science, PubMed, Springer Link, Cochrane Library, Science Direct, Embase, and Google Scholar were utilized to extract relevant studies. The statistical software MedCalc version 22.009 was acquired to accomplish the meta-analysis of the included studies.

Results
A significant association was found between two SNPs (rs4880 and rs1050450) and DN in the homozygous recessive model [95% confidence interval (CI) 0.97–2.41, odds ratio (OR) TT vs CC = 1.53, P = 0.06] and heterozygous model [95% CI 0.92–1.97, OR CT vs CC = 1.35, P = 0.12], while there was no association with the other genetic models. A significant association between rs4880 and DN was perceived in the Asian population [95% CI 1.24–2.03, OR = 1.6, P < 0.001], meanwhile the studies among Caucasian group showed insignificant association [95% CI 0.87–1.32, OR = 1.07, P = 0.5]. On the other hand, the association between rs1050450 and DN was significant [95% CI 3.80–13.01, OR = 7.04, P < 0.001] and insignificant [95% CI 0.96–2.28, OR = 1.48, P = 0.07] among Asian and Caucasian population, respectively.

Conclusion
To date, this meta-analysis could be the first to contribute a panoramic exploration of the MnSOD and GPx1 polymorphic association with DN. The results of the study contemplate the data presently accessible from the literature and can be employed as an influential lead for future research.
Characterization of mitochondrial DNA mutations in colorectal cancer progression by in silico approach and use as potential biomarkers for diagnosis and prognosis
Authors: Gadicherla Ramya , Rai Niraj , Othayoth Rajath , Kamma Srinivasulu 
Published: October 2024

Abstract
Background
Mitochondrial DNA variants are significant contributors to cancer progression, as evidenced by numerous findings. This study focuses on characterizing mitochondrial DNA mutations in colorectal cancer progression and their potential as biomarkers.

Methodology
Next generation sequencing technology was employed to analyze mitochondrial DNA variants in tumor and adjacent normal tissues from 25 patients with colon/rectal cancer. In silico prediction tools (SIFT, Polyphen2, Mutation Assessor, and SNP&GO) were utilized to assess the pathogenicity of these variants. Additionally, homology modeling of mutated protein structures was conducted, and molecular dynamic simulations were performed to assess the impact of mutation on protein function.

Results
Eighteen variants were identified across most tumor tissue samples, located in genes from Complex I, IV, and V. Among the identified variants, the V302M and S461 mutations in the MT-ND5 gene and L137F and L220P mutations in the ATP6 gene were predicted to be deleterious, potentially affecting protein function. 3D structural analysis of both wild-type and mutant proteins of MT-ND5 revealed changes in flexibility for the V302M and S461G mutations. The MT-ATP6 mutations L135F and L220P disrupt the interactions with surrounding residues and affect the overall function of protein. Further changes in protein dynamics of the mutated proteins by molecular dynamic simulations also indicate the effects; the mutations have on protein function.

Conclusion
MT-ND5 and MT-ATP6 variants could serve as potential biomarkers and drug targets in colorectal cancer. This study underscores the significance of mitochondrial DNA variants in cancer progression.
Early- and mid-term outcomes following redo aortic surgeries: a retrospective cohort study
Authors: Akintoye Oluwanifemi , Mishra Namrata , De Silva Ravi 
Published: October 2024

Abstract
Background
Redo aortic surgeries are complex procedures known to be associated with increased morbidity and mortality compared to patients who undergo de novo aortic procedures. We aimed to report the survival and outcomes following redo aortic surgeries in our centre. We performed a retrospective cohort study of 77 patients who underwent redo aortic surgery between January 1st, 2018, and August 30th, 2023. The primary outcome of interest was operative mortality. Other secondary outcomes of interest included overall mortality, survival rates, and other peri-operative major adverse events. Survival analysis was performed and Cox- proportional hazard regression models were fitted to explore the relationship between exposure variables and outcomes of interest in the total cohort of patients.

Results
The mean age of the total cohort was 64.22 ± 12.22 years with majority being males (n = 57, 69.3%). The most common indication for redo surgery was aortic aneurysm (n = 41, 53.2%) and majority of the patients had a first redo aortic surgery (n = 69, 89.6%). The rate of freedom from in-hospital mortality was 63.1% (95% confidence interval (CI) 35.4–100%). Overall survival rate during the 5-year study period was 73.1% (95% CI 62.6–85.4%) in the whole cohort. The factors found to be predictive of overall mortality were priority of surgery hazard ratio (HR) 3.48 (95% CI 1.20–10.05, p = 0.02), time to re-operation HR 0.89 (95% CI 0.81–0.99, p = 0.025), pre-operative chronic kidney disease HR 3.16 (95% CI 1.18–8.43, p = 0.022), need for mechanical circulatory support HR 12.7 (95% CI 4.23–38.12, P < 0.001), post-operative renal dysfunction requiring hemofiltration HR 4.03 (95% CI 1.50–10.79, p = 0.006), and post-op re-exploration HR 47.82 (95% CI 13.9–164.4, p < 0.001).

Conclusions
Our study shows that short-term and mid-term outcomes following redo aortic surgery are favourable. The factors found to be associated with overall mortality include post-op re-exploration, renal dysfunction, use of post-op mechanical circulatory support, priority of surgery, and time to re-operation.

Graphical Abstract
Summary of outcomes following redo aortic surgery over a 5-year period (2018–2013). CI, confidence interval; HR, hazard ratio; CKD, chronic kidney disease, AKI, acute kidney injury, MCS, mechanical circulatory support.
Successful surgical repair of aortic root rupture during transcatheter aortic valve implantation: a case report
Authors: Numaguchi Ryosuke , Yokoyama Noriyuki , Ishikawa Kazunori , Koya Atsuhiro , Tokuda Yusuke , Shingaki Masami 
Published: October 2024

Abstract
Background
Aortic root rupture is a rare but potentially fatal complication of transcatheter aortic valve implantation (TAVI). Herein, we report a case of aortic root rupture during TAVI that was successfully managed with partial aortic root repair and aortic valve replacement.

Case presentation
An 83-year-old woman with severe bicuspid aortic stenosis underwent transfemoral TAVI using a 26 mm SAPIEN 3 Ultra RESILIA valve. Soon after valve implantation, transesophageal echocardiography detected pericardial effusion, which was accompanied by immediate hemodynamic instability. Subxiphoid pericardial drainage was performed, and extracorporeal membrane oxygenation was promptly initiated. Owing to the eruptive hemorrhage, we converted to open-heart surgery. Direct visualization enabled the detection of the aortic root rupture and the performance of partial aortic root repair using bovine pericardium and aortic valve replacement using a 19 mm INSPIRIS RESILIA valve. The patient was transferred to a different hospital 60 days after surgery without complications and is currently doing well as an outpatient.

Conclusions
In the present case, prompt treatment decisions and smooth cooperation among the institutional heart team led to the successful repair of aortic root rupture during TAVI and good clinical outcomes.
Intraoperative Anesthesia-Related Critical Events in Low-Resource Hospitals During Short-Term Surgical Missions in Tanzania and Democratic Republic of the Congo: An Observational Study
Authors: Ponthus Simon , Omari Amina , Tesha Selerina , Mbuza Castram , Peruzzo Alexis , Kabuya Pierre , Yamuremye Richard , Dumont Lionel 
Published: October 2024

BACKGROUND:
Critical incidents and mortality related to anesthesia are more frequently observed in low- and middle-income countries in comparison to high-income countries. The difficulties linked to anesthesia in rural areas of the Democratic Republic of the Congo (DRC) and Tanzania have limited documentation. The aim of this study was to comprehensively document anesthesia-related critical events that occurred during surgical missions organized by the nongovernmental organization 2nd Chance in hospitals in DRC and Tanzania.

METHODS:
Data were collected during 6 surgical missions in 3 hospitals in the DRC and 1 in Tanzania. All scheduled surgery patients were included. Anesthesia was administered by a local Non-Physician Anesthesia Provider (NPAP), using local resources, under the supervision of an anesthesiologist from the association. The anesthesiologist reported critical events and collected data. Local teams managed critical events initially, with intervention by the anesthesiologist from 2nd Chance on the local team’s request, according to preestablished protocol or if the situation was considered dangerous. Critical incidents associated with anesthesia, including bradycardia, hypoxemia, airway management failure, and equipment problems, were documented from induction of anesthesia until discharge from the recovery room.

RESULTS:
We recruited 201 patients, of whom 192 were evaluated, with 9 patients dropping out due to protocol noncompliance. All patients were American Society of Anesthesiologists (ASA) I (62%; n = 120) or ASA II (38%; n = 72). Among them, 104 individuals (54%) experienced at least 1 critical event, totaling 202 critical events. Hypoxemia emerged as the most common event, affecting 29% of the patients (n = 55) with at least 1 episode. Equipment problems (oxygen supply and/or anesthesia machine failure) occurred in 24% of cases (n = 46), airway management issues in 23% (n = 44), and bradycardia in 6% (n = 12). Hypotension and hypertension were not documented due to the lack of monitoring. The majority of these events (over 60%) required intervention by the anesthesiologist.

CONCLUSIONS:
The occurrence of critical events related to anesthesia appears to be high in this study. Due to numerous limitations, these results cannot be generalized to all hospitals in Tanzania and the DRC. However, this study underscores the challenges faced by anesthesia teams, encompassing inadequate resources, equipment deficiencies, and varying levels of expertise among anesthesia personnel. The research further stresses the significance of addressing these challenges to enhance patient safety.
A high-fat plus high-sucrose diet induces age-related macular degeneration in an experimental rabbit model
Authors: Wang Yujiao , Lv Zhongping , Chen Yongjiang , Cen Xiaobo , Zhang Hui , Chen Danian 
Published: October 2024

ABSTRACT
Age-related macular degeneration (AMD) is a leading cause of blindness. Metabolic disorders and diets are risk factors. We compared lipid profiles and retinal phenotypes with long-term feeding of four diets in male Chinchilla rabbits. Animals were fed a normal diet (ND), high-fat diet (HFD), high-sucrose diet (HSD) or a high-fat plus high-sucrose diet (HFSD) for 6 months. Eyes were examined using multimodal imaging modalities and electroretinograms. Retinal sections were analyzed using H&E staining, Toluidine Blue staining, immunostaining and transmission electron microscopy. Lipids and complement C3 protein (C3) in serum or aqueous humor were measured. RNA sequencing was performed to evaluate the retinal transcriptomes. HFD and HSD had minor effects on lipid profiles but, when fed concomitantly, synergistically induced severe dyslipidemia. None of the four diets caused obesity. HFSD induced retinal lesions, such as reticular pseudodrusen (RPDs) and other pigmentary abnormalities. RPD-like lesions were mainly lipid droplets around cells of the retinal pigment epithelium. HFSD also induced elevated levels of ocular C3 and reduced the density of retinal vessels. In conclusion, HFD and HSD can – when combined − induce normal-weight dyslipidemia and RPD-like retinal lesions. HFSD-fed male Chinchilla rabbits are a good model of early AMD.
Thin-film lithium niobate polarization-independent modulators for mode and polarization multiplexing
Authors: Shi Jiakang , Ye Zhilin , Liu Zhen , Lv Mengcheng , Ge Daohan , Zhang Liqiang 
Published: October 2024

We demonstrated a high-order mode modulator based on thin-film lithium niobate (TFLN). By introducing a mode converter and a polarization splitter-rotator (PSR), the modulator can achieve dual-mode modulation. Additionally, we designed a periodic capacitively loaded traveling-wave electrode on TFLN to enhance modulation efficiency and bandwidth. The modulator exhibits a polarization extinction ratio greater than 20 dB at a wavelength of 1550 nm, a modulation efficiency of V
π
LTE0=2.541V⋅cm and V
π
LTM0=2.570V⋅cm, and a 3 dB bandwidth exceeding 60 GHz. This not only meets the requirements for polarization-independent modulators but also supports on-chip multimode applications such as mode and polarization multiplexing.
Low-noise soliton molecule generation with an in-phase controllable pulse number by third- and second-order dispersion compensation in an all-fiber erbium-doped oscillator
Authors: Ismaeel Almikdad , Orekhov Ilya O. , Sazonkin Stanislav G. , Dvoretskiy Dmitriy A. , Krylov Aleksandr A. , Karasik Valeriy E. , Denisov Lev K. 
Published: October 2024

We report on the experimental results of high-order
soliton molecule (SM)
generation in an erbium-doped oscillator. The generation of 14
solitons with an average power of 48 mW, a pulse duration of 508 fs, a
separation of 2.59 ps between pulses, and a repetition rate of 19 MHz
at 1560 nm central wavelength was demonstrated. The stability of this
generation was also evidenced by its low relative intensity noise
(0.08% in the frequency range [10 kHz–1 MHz]), and a low Allan
deviation of frequency repetition rate of 1.98⋅10−9 at an interval of 1 s (during 10 h of
free-running measurements). Moreover, the accurate manipulation of SM
order by changing the pump power was investigated; we showed the
ability to generate with four, six, seven, nine, 10, 11, 13, and 14
pulses with high stable states between solitons. The change in the
number of pulses occurred repeatably by increasing and decreasing the
pump power, offering a stable source of a controllable number of
pulses for potential applications in quantum computing.
Ultrabroadband thin-film lithium tantalate modulator for high-speed communications
Authors: Wang Chengli , Fang Dengyang , Zhang Junyin , Kotz Alexander , Lihachev Grigory , Churaev Mikhail , Li Zihan , Schwarzenberger Adrian , Ou Xin , Koos Christian , Kippenberg Tobias J. 
Published: October 2024

The continuous growth of global data traffic over the past three
decades, along with advances in disaggregated computing architectures,
presents significant challenges for optical transceivers in
communication networks and high-performance computing systems.
Specifically, there is a growing need to significantly increase data
rates while reducing energy consumption and cost. High-performance
optical modulators based on materials such as InP, thin-film lithium
niobate (), or plasmonics have been developed,
with excelling in high-speed and
low-voltage modulation. Nonetheless, the widespread industrial
adoption of thin-film remains compounded by the rather high
cost of the underlying “on insulator”
substrates—in sharp contrast to silicon photonics, which can
benefit from strong synergies with high-volume applications in
conventional microelectronics. Here, we demonstrate an integrated
110 GHz modulator using thin-film lithium tantalate ()—a material platform that is
already commercially used for millimeter-wave filters and that can
hence build upon technological and economical synergies with existing
high-volume applications to offer scalable low-cost manufacturing. We
show that the photonic integrated circuit based
modulator can support 176 GBd PAM8 transmission at net data
rates exceeding 400 LiNbO3. Moreover, we show that using silver
electrodes can reduce microwave losses compared to previously employed
gold electrodes. Our demonstration positions the modulator as a novel and highly
promising integration platform for next-generation high-speed,
energy-efficient, and cost-effective transceivers.
Determinants of location changes in the clothing industry in Poland
Authors: Kocaj Arkadiusz , Murzyn-Kupisz Monika 
Published: October 2024

Abstract
The clothing industry is often perceived, particularly in the European context, as a declining, traditional, labour-intensive industry. Nonetheless, in recent years in Poland, after over three decades of steady shrinkage, though the average scale of operations has continued to decline, the number of firms in the sector has been much more stable. In their analysis of the locations of apparel producers on the national level, the authors point to the changing geography of the sector in terms of its increased or diminishing relative presence in some areas. The links between location tendencies among firms in the clothing industry and other fashion-related institutions and initiatives are noted, as are new firms in the creative sector. The spatial patterns observed point to the ability of the resized sector to leverage emerging market opportunities and upgrade selectively, and to its broader evolution from a traditional towards a creative industry.
Multi-proxy analysis of an Early Neolithic wooden well in a pastoral landscape in eastern Bohemia
Authors: Vostrovská Ivana , Kočár Petr , Kočárová Romana , Kašák Josef , Lisá Lenka , Petr Libor , Sůvová Zdeňka , Horsák Michal , Muigg Bernhard , Tegel Willy , Bajer Aleš , Rohovec Jan , Rybníček Michal , Kolář Tomáš , Nosek Vojtěch , Bartoš Marek 
Published: October 2024

Abstract
Some of the most remarkable Neolithic finds encountered in central Europe are wells with a wooden construction. These features provide unusual insights into Neolithic societies, their subsistence strategies and the landscape they inhabited. In the last fifteen years, four Early Neolithic wells out of a total of seven such wells known since the 1970s have been discovered in Czechia. One of them is the well at Ostrov, the wooden construction and sedimentary infill of which have made it possible to study diverse topics by taking a multi-proxy approach using a range of complementary methods. The study presented here compares different periods of the well’s existence, examines the carpentry skills of the first farmers, investigates sedimentary processes, reveals details about the use and decline of the well, addresses its location relative to that of the settlement, and reconstructs the environment of the well itself and the surrounding landscape. The water well at Ostrov is a highly unusual find because it probably existed outside of a settlement. The grooved wooden lining used is identical to that of previously investigated wells inside settlements, as are the processes of its use and decline. However, environment-related indicates that the Ostrov well was located in an open landscape with sparse vegetation and was perhaps only used by-passing herdsmen.