bluuebunny/crossref_metadata_2025_split huggingface dataset:
A small set of stylometric features differentiates Latin prose and verse
Authors: Chaudhuri Pramit , Dasgupta Tathagata , Dexter Joseph P , Iyer Krithika 
Published: October 2018

AbstractIdentifying the stylistic signatures characteristic of different genres is of central importance to literary theory and criticism. In this article we report a large-scale computational analysis of Latin prose and verse using a combination of quantitative stylistics and supervised machine learning. We train a set of classifiers to differentiate prose and poetry with high accuracy (&gt;97%) based on a set of twenty-six text-based, primarily syntactic features and rank the relative importance of these features to identify a low-dimensional set still sufficient to achieve excellent classifier performance. This analysis demonstrates that Latin prose and verse can be classified effectively using just three top features. From examination of the highly ranked features, we observe that measures of the hypotactic style favored in Latin prose (i.e. subordinating constructions in complex sentences, such as relative clauses) are especially useful for classification.
The management of chronic cough
Authors: Mathur A , Liu-Shiu-Cheong P S K , Currie G P 
Published: October 2018

Summary
Chronic cough is a common presentation to primary care and constitutes a significant volume of referrals to secondary care. It affects around 10% of the adult population and has a plethora of respiratory and non-respiratory causes. It can have a significant impact on the quality of life of affected individuals. In many patients, minimal baseline investigations lead to an easily identifiable and treatable cause. In others, no cause can be identified even after extensive investigations in specialized cough clinics. This evidence-based review article outlines the approach to the adult patient presenting with chronic cough and focuses upon current management strategies in those with chronic idiopathic cough. It includes results from trials of speech and language therapies, and the emerging concept of chronic idiopathic cough as a neuropathic disorder with its own bespoke approach to management including the use of neuromodulatory agents.
Risk Factors for Surgical Site Infection in Minor Dermatological Surgery: A Systematic Review
Authors: Delpachitra Meth Ruvinda , Heal Clare , Banks Jennifer , Divakaran Pranav , Pawar Mrinal 
Published: October 2018

ABSTRACT

OBJECTIVE:
To identify patient- and procedure-related risk factors for surgical site infection following minor dermatological surgery.

DATA SOURCES:
The MEDLINE, Cumulative Index of Nursing and Allied Health Literature, Informit, and Scopus databases were searched for relevant literature on patient populations receiving minor surgery, where risk factors for surgical site infection were explicitly stated.

STUDY SELECTION:
Studies involving major dermatological surgery were excluded. The preliminary search yielded 820 studies after removing duplicates; 210 abstracts were screened, and 42 full texts were assessed for eligibility. A total of 13 articles were included. Studies were appraised using the Newcastle-Ottawa Quality Assessment Scale.

DATA EXTRACTION:
An electronic data collection tool was constructed to extract information from the eligible studies, and this information was distributed to participating authors.

DATA SYNTHESIS:
Risk factors identified included age, sex, diabetes mellitus, chronic obstructive pulmonary disease, use of antihypertensive or corticosteroid medications, smoking, surgery on the lower or upper extremities, excision of nonmelanocytic skin cancers, large skin excisions, and complex surgical techniques. No more than two studies agreed on any given risk factor, and there were insufficient studies for meta-analysis.

CONCLUSIONS:
Re-excision of skin cancer, below-knee excisions, and intraoperative hemorrhagic complications were predictive for infection in more than one study. More high-quality studies are required to accurately identify risk factors so they can be reliably used in clinical guidelines.
Adverse childhood experiences and implementing trauma-informed primary care
Authors: Esden Jana L. 
Published: October 2018

Abstract:
Adverse childhood experiences (ACEs) include exposures such as abuse and household dysfunction. These exposures are associated with long-term sequelae and unfavorable health outcomes in adulthood. NPs working in primary care can help to reduce the impact of ACEs in adulthood by identifying individuals with these experiences and implementing trauma-informed care strategies.
Unicortical Fixation is Sufficient for Surgical Treatment of Tibial Tubercle Avulsion Fractures in Children
Authors: Arkader Alexandre , Schur Mathew , Refakis Christian , Capraro Anthony , Woon Regina , Choi Paul 
Published: October 2018

Background:
Although open reduction and internal fixation are recommended for displaced tibial tubercle avulsion fractures in young athletes, whether to use unicortical or bicortical fixation is debatable. The purpose of this study is to compare the outcomes of unicortical versus bicortical fixation in a series of pediatric tibial tubercle avulsion fractures.

Methods:
We reviewed a consecutive series of patients with tibial tubercle fractures treated surgically at 2 level-1 pediatric tertiary care centers over a 12.5-year period. Patients aged below 18 years of age who received surgical treatment for displaced tibial tubercle fractures with postoperative follow-up were included. Fractures were classified using a modified Ogden classification system. The relative proportion of fracture types treated and incidence of complications were compared.

Results:
The cohort included 90 fractures in 86 patients. There were 82 male and 4 female individuals; average age was 14.7 years (range, 9.0 to 18 y). In total, 87 of 90 were treated with open reduction and internal screw fixation [51 unicortical (59%), 13 mixed (15%), 23 bicortical (26%)] and 3 with percutaneous pinning. All patients were followed-up until healing and postoperative follow-up average was 8 months (range, 3 to 34 mo). There were no significant differences between the 2 groups with regard to patient age (P=0.22), patient weight (P=0.22), and activity clearance times [unicortical: 19.9 wk (range, 10.4 to 42.3 wk); bicortical: 17.7 wk (range, 12.1 to 32 wk); P=0.19]. The mixed cortical group was cleared at an average of 19.9 weeks (range, 10.6 to 29.1 wk). The relative proportion of fracture patterns treated differed negligibly between the unicortical and bicortical groups. Complications were noted in 9 of 90 procedures (10% rate); all subjects showed evidence of full radiographic healing at last follow-up.

Conclusions:
There was no difference in outcome whether unicortical or bicortical fixation was used. All patients exhibited full healing and return to activities with very low-complication rates. The results of this study suggest the adequacy of unicortical fixation for treating tibial tubercle fractures in young athletes.

Level of Evidence:
Level III—retrospective comparative study.
Trochlear Dysplasia and Its Relationship to the Anterior Distal Femoral Physis
Authors: Parikh Shital N. , Rajdev Neil 
Published: October 2018

Background:
Trochlear dysplasia is a known risk factor for patellar instability in adolescent patients. A spatial relationship between dysplastic trochlea and anterior distal femoral physis has not been established. The purpose of this study was to investigate this relationship. Our hypothesis was that the position of the dysplastic trochlea and trochlear bump would coincide with the anterior distal femoral physis and that the distance between them would increase with age.

Methods:
In a retrospective study, magnetic resonance images of adolescents with trochlear dysplasia were evaluated. Measurements performed included trochlear depth, trochlear bump size, proximal trochlea-physis distance, and trochlear bump-physis distance. Linear regression analyses were performed to correlate the variables with increasing age.

Results:
In total, 175 knees (160 patients) with trochlear dysplasia were included. The mean trochlea-physis distance was 4.50 mm (SD=1.93) and it increased with age (slope=0.26; P<0.01). The lateral aspect of trochlea was proximal to the physis in 24 (13.7%) knees and was at the level of the physis in 31 (17.7%) knees. The size of trochlear bump increased with age (slope=0.15; P=0.01). The bump-physis distance increased with age (slope=0.41; P<0.01).

Conclusions:
The dysplastic trochlea is closely related to the anterior distal femoral physis. The distance between the dysplastic trochlea and femoral physis increases with age. The close relationship between proximal aspect of trochlea and anterior distal femoral physis should be considered when trochlear surgery is planned in skeletally immature patients.

Level of Evidence:
Level II.
A Bundled Payment Model for Pediatric Distal Radius Fractures: Defining an Episode of Care
Authors: Godfrey Jenna M. , Little Kevin J. , Cornwall Roger , Sitzman Thomas J. 
Published: October 2018

Background:
Distal radius fractures are the most common fracture of childhood, occurring in ∼1 per 100 children annually. Given the high incidence of these fractures, we explored feasibility of a bundled payment model. We determined the total treatment costs for each child and identified components of fracture management that contributed to variations in cost.

Methods:
We retrospectively reviewed all hospital and physician costs related to the treatment of closed distal radius fractures at a large academic children’s hospital. We included all children age 2 to 15 years treated by an orthopaedic surgeon for an isolated closed distal radius fracture between 2013 and 2015. We compared total treatment costs by fracture management approach. We then estimated the contribution of each component of fracture management to total treatment costs using linear regression.

Results:
We identified 5640 children meeting the inclusion criteria, of which 4602 (81.6%) received closed treatment without manipulation, 922 (16.3%) underwent closed reduction in the clinic, emergency department, or radiology procedure suite, and 116 (2.1%) underwent treatment in the operating room. The median cost for closed treatment without manipulation was $1390 [interquartile range (IQR) 1029 to 1801], compared with $4263 (IQR, 3740 to 4832) for closed reduction and $9389 (IQR, 8272 to 11,119) for closed reduction and percutaneous pinning (P<0.001). In multivariable regression analysis, fracture management approach and use of the operating room environment were the largest cost drivers (P<0.001, R
2=0.88). Closed reduction in the clinic or emergency department added $894 (95% confidence interval, 819-969) to treatment costs, while closed reduction in the operating room added $5568 (95% confidence interval, 5224-6297). Location of the initial clinical evaluation, number of radiographic imaging series obtained, and number of orthopaedic clinic visits also contributed to total costs.

Conclusions:
Closed pediatric distal radius fractures treated without manipulation show small variations in treatment costs, making them well suited for bundled payment. Bundled payments for these fractures could reduce costs by encouraging adoption of existing evidence-based practices.

Level of Evidence:
Level III—therapeutic.
Sacroiliac Pain
Authors: DePhillipo Nicholas N. , Corenman Donald S. , Strauch Eric L. , Zalepa King Lisa A. 
Published: October 2018

Background:
The currently reported incidence of primary sacroiliac joint (SIj) pathology ranges from 15% to 30%. The differential diagnosis of SIj region pain includes pain generated from the lumbar spine, the SIj, and the hip joint. The origins of SIj dysfunctions are controversial and pain generation from this joint has been questioned.

Purpose:
Retrospectively analyze the relative incidence of lumbar spine, SIj, and hip joint etiologies in patients complaining of ≥50% SIj region pain.

Study Design:
This is a retrospective cohort case series.

Methods:
Inclusion criteria: chief complaint SIj pain (≥50% of overall complaint). In total, 124 patients charts were reviewed from a single spine surgeon’s clinic. All patients were evaluated by the same 2 practitioners and all cases were reviewed for clinical examination findings, diagnostic tests performed, final diagnosis, treatment, and clinical follow-up.

Results:
After complete diagnostic workup, 112 (90%) had lumbar spine pain, 5 (4%) had hip pain, 4 (3%) had primary SIj pain, and 3 (3%) had an undetermined source of pain upon initial diagnosis. SIj pain generation was confirmed via fluoroscopy-guided diagnostic injections. Following designated treatment, 11 (9%) patients returned to clinic at an average of 2.4 years complaining of continued/recurrent SIj region pain. Further investigation revealed 6 patients had confirmed pain generation from the lumbar spine, 3 patients had confirmed pain generation from the SIj, and 2 patients had undetermined sources of pain.

Conclusions:
The SIj is a rare pain generator (3%–6%) in patients complaining of ≥50% SIj region pain and is a common site of referral pain from the lumbar spine (88%–90%). Clinicians ought to quantify areas of pain (via percent of overall complaint) when interviewing their patients complaining of low back pain to distinguish potential pain generators. Recommended breakdown of areas of interest include axial low back, SIj region, buttock/leg, groin/anterior thigh.
Treatment of the Prominent Ear: A Standardized Approach Without Intraoperative Measurements
Authors: MacIsaac Zoe M. , Zammerilla Lauren , Grunwaldt Lorelei J. 
Published: October 2018

Background:
Candidates for otoplasty have variable anatomy that may result in an aesthetically suboptimal appearance. The authors describe an algorithm to obtain ideal aesthetic position of the ear using a standardized suturing only technique.

Methods:
A retrospective review was conducted at a major children's hospital. Pre- and postoperative distances from the mastoid to the posterior lateral helical rim were measured at 3 consistent points (upper helix, mid helix, and lobule). Cosmetic outcomes were determined by visual analog cosmetic score (VACS), assigned by 3 independent reviewers.

Results:
A total of 26 patients underwent otoplasty for prominent ear (average age 8.2 years). Duration of follow-up was an average of 32 weeks postoperatively. Pre- and postoperative VACSs were determined for all patients: overall-appearance, 25.8 versus 71.3; overall-ear appearance, 25.7 versus 70.0; shape, 24.4 versus 72.6; and projection, 23.7 versus 73.9 (P < 0.05 for all). There was no inter-rater difference between scores. There was greater symmetry between ears postoperatively (P < 0.05). Measurements were significantly improved pre- versus postoperatively: upper-helix 2.04 versus 1.20 cm, mid-helix 2.22 versus 1.18 cm, and lobule 1.85 versus 1.49 cm (P < 0.05.) Postoperative measurements are in accordance with established norms for ideal ear position (1.0–1.2 cm upper third of the ear). Two patients recurred, and 1 experienced a spitting suture (11.5%).

Conclusion:
Aesthetic ideal was established on the operating table based on the appearance of the ear. Postoperative measurements fell within aesthetic ideal for a normal ear, suggesting that the use of intraoperative measurements are not needed to obtain an aesthetically acceptable outcome.
Postsurgical Changes in Osseous Dysmorphology of the Midface and Mandible in Unilateral Coronal Craniosynostosis
Authors: Jo Sally , Skolnick Gary B. , Naidoo Sybill D. , Smyth Matthew D. , Patel Kamlesh B. 
Published: October 2018

Background:
Early management of unilateral coronal synostosis (UCS) aims to treat the cranial abnormality with the hope of improving middle and lower facial morphology. This study analyzed osseous volume and 3-dimensional distances in the midface and mandible of patients with UCS to assess changes in facial symmetry following a cranial vault procedure.

Methods:
Patients who underwent fronto-orbital advancement for UCS repair between 1981 and 2012 with follow-up of at least 3 years were included. Computed tomography-based 3-dimensional reconstructions of the mandible and LeFort III midface were divided by 3 midline osseous landmarks and measured for volume. Distances between 11 osseous landmarks were measured in the midface and mandible. Ratios between the measurements on synostotic and nonsynostotic sides were calculated. Presurgical to postsurgical changes were evaluated with paired samples t tests. The study was powered to detect differences between preoperative and postoperative ratios of at least 3%.

Results:
Eleven patients were included. Mean age at initial imaging was 4.7 ± 3.2 months (range, 0.4–9.2 months) with postoperative follow-up of 9.0 ± 5.3 years (range, 3.3–17.0 years). Midfacial symmetry of osseous volume improved following surgery (synostotic to nonsynostotic ratio, 94.1% vs 98.9%, P = 0.044). The width (P < 0.001), height (P = 0.039), and anterior–posterior depth of the midface (P = 0.011) also became more symmetric. In the mandible, however, volumetric and linear symmetry did not improve.

Conclusions:
Symmetry of the midface, but not the mandible, improves significantly following the cranial procedure in patients with UCS.
Hemato-oncology and palliative care teams: is it time for an integrated approach to patient care?
Authors: LeBlanc Thomas W. , El-Jawahri Areej 
Published: October 2018

Purpose of review
Integrated palliative care for those with advanced solid tumors yields significant benefits in patient and caregiver outcomes. However, most palliative care clinical trials have excluded patients with hematologic malignancies. There is growing interest in whether integrated palliative care may yield similar benefits in hematologic malignancy patients and caregivers, but there has been little direct evidence of benefit in this population. This review summarizes new data on palliative care issues in hematologic malignancies, published in the preceding 12 months.

Recent findings
Most newly published evidence on this topic from the last year is descriptive of unmet needs, poor end-of-life care outcomes or unique differences and issues posed by hematologic malignancies as compared to solid tumors. A few articles describe models of collaborative care in hematologic malignancies, and just one describes the impact of an integrated palliative care intervention on patient and caregiver outcomes. Several studies point to transfusions as a unique and problematic barrier to high-quality end-of-life care in hematologic malignancies.

Summary
Recent evidence confirms that hematologic malignancy patients have unique and often unmet palliative care needs, and also have worse end-of-life outcomes. More work is needed to develop and test integrated palliative care interventions in this population.
Precious cargo: Modulation of the mesenteric lymph exosome payload after hemorrhagic shock
Authors: Williams Elliot C. , Coimbra Raul , Chan Theresa W. , Baird Andrew , Eliceiri Brian P. , Costantini Todd W. 
Published: October 2018

BACKGROUND
Trauma/hemorrhagic shock (T/HS) causes a release of proinflammatory mediators into the mesenteric lymph (ML) that may trigger a systemic inflammatory response and subsequent organ failure. Recently, we showed that exosomes in postshock ML are biologically active mediators of this inflammation. Because the specific inflammatory mediators in postshock ML exosomes have yet to be characterized, we hypothesized that T/HS would lead to a distinct ML proinflammatory exosome phenotype that could be identified by proteomic analysis. We further hypothesized that their regulation by the neuroenteric axis via the vagus nerve would modify this proinflammatory profile.

METHODS
Male rats underwent an established T/HS model including 60 minutes of HS followed by resuscitation. Mesenteric lymph was collected before HS (preshock) and after resuscitation (postshock). A subset of animals underwent cervical vagus nerve electrical stimulation (VNS) after the HS phase. Liquid chromatography with tandem mass spectroscopy (LC-MS/MS) followed by protein identification, label free quantification, and bioinformatic analysis was performed on exosomes from the pre-shock and post-shock phases in the T/HS and T/HS + vagus nerve electrical stimulation groups. Biological activity of exosomes was evaluated using a monocyte nuclear factor kappa B (NF-κB) activity assay.

RESULTS
ML exosomes express a distinct protein profile after T/HS with enrichment in pathways associated with cell signaling, cell death and survival, and the inflammatory response. Stimulation of the vagus nerve following injury attenuated the transition of ML exosomes to this T/HS-induced inflammatory phenotype with protein expression remaining similar to pre-shock. Monocyte NF-κB activity was increased after exposure to ML exosomes harvested after T/HS, while ML exosomes from preshock had no effect on monocyte NF-κB expression.

CONCLUSION
Postshock ML exosomes carry a distinct, proinflammatory protein cargo. Stimulating the vagus nerve prevents the T/HS-induced changes in ML exosome protein payload and suggests a novel mechanism by which the neuroenteric axis may limit the systemic inflammatory response after injury.
Time course and outcomes associated with transient versus persistent fibrinolytic phenotypes after injury: A nested, prospective, multicenter cohort study
Authors: Roberts Derek J. , Kalkwarf Kyle J. , Moore Hunter B. , Cohen Mitchell J. , Fox Erin E. , Wade Charles E. , Cotton Bryan A. 
Published: October 2018

BACKGROUNDTemporal changes in fibrinolytic activity after injury and their impact on outcomes remain poorly defined. We conducted a prospective, multicenter cohort study to determine the incidence of fibrinolytic phenotypes after injury and the trajectories and associated outcomes of these phenotypes over time.METHODSWe included adults that arrived within 6 hours of injury to three American Level I trauma centers. Clot lysis at 30 minutes (LY-30) was measured at presentation and at 3 hours, 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours, and 120 hours. LY-30 was used to categorize patients into the following fibrinolytic phenotypes: fibrinolysis shutdown (SD, LY-30 ≤0.8%), physiologic fibrinolysis (PHYS, LY-30 >0.8% to <3%), or hyperfibrinolysis (HF, LY-30 ≥3%). We used multivariable logistic regression to estimate adjusted odds ratios for mortality.RESULTSWe included 795 adults (median age, 38 years; median Injury Severity Scale score, 21). In total, 44% presented with SD, 36% with PHYS, and 21% with HF. Mortality was highest among those who presented with HF (20%) followed by SD (10%) and PHYS (7%) (p= 0.001). While mortality within the first 24 hours was highest with admission HF (14% vs. 5% SD vs. 4% PHYS;p= 0.001), both admission HF (7%) and SD (6%) had higher mortality after 24 hours compared with PHYS (3%) (p= 0.04). All patients who presented with HF switched into another phenotype or died within 24 hours. The majority of patients that presented in SD remained in that phenotype, including 71% at 24 hours and 72% at 120 hours. Persistent SD at 24 hours was independently associated with increased mortality after 24 hours (odds ratio, 3.20; 95% confidence interval, 1.51–6.67).CONCLUSIONApproximately 70% of major trauma patients who present with SD remain in this phenotype up to 120 hours postinjury. In contrast, patients presenting with HF transition into another phenotype or die within 24 hours. While early mortality is highest with the HF phenotype, persistent SD at 24 hours is associated with elevated late mortality.LEVEL OF EVIDENCEPrognostic and epidemiological study, level II.