bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the intellectual disability severity in the Spanish Personal Outcomes Scale
Authors: Carbó‐Carreté M. , Guàrdia‐Olmos J. , Peró‐Cebollero M. , Giné C. 
Published: May 2019

AbstractBackgroundThe interest in measuring quality of life (QoL) in persons with intellectual disability (ID) has brought about a number of QoL measurements for this population. These measurements need to address two issues that have contributed to enhancing the current instruments. First, the necessity to develop measures with adequate psychometric properties, which has been discussed in recent studies, and second, the agreement between experts in analysing objective and subjective perspectives, as well as the use of self‐report to include the participation of the person with ID. The question that we set out to investigate in this paper is whether the measurements function properly for the person with ID, independent of their level of severity. We used the Spanish version of the Personal Outcomes Scale, as it is a psychometrically sound instrument and includes three sources of information (the person with ID, a professional and a family member).MethodThe sample was composed of 529 persons with ID (296 men, representing 55.95% of the total sample, and 233 women, with Mage = 35.03, SD = 10.82) from several regions of Spain, along with their professional of reference and a family member. The severity variable was estimated for each item based on estimations of differential item functioning.ResultsThe results showed that several items were undervalued by the assessments if the severity of the ID was greater. Mainly, this difference was observed in the assessments by professionals and in the dimensions of rights, personal development and self‐determination.ConclusionsThis paper focuses on the uses and interpretations of the results of the QoL measurements in the Personal Outcomes Scale. The results indicate that, in our sample, when people with high levels of ID are assessed, the functioning of some items are affected by the severity of this disability. For correct use, these items must be interpreted on the basis of the results obtained. Additionally, it is necessary to thoroughly review the QoL indicators for persons with severe or profound ID.
Assessing the Accuracy of Casting and Additive Manufacturing Techniques for Fabrication of a Complete Palatal Coverage Metal Framework
Authors: Forrester Keaton , Sheridan Ryan , Phoenix Rodney D. 
Published: May 2019

AbstractPurposeTo provide information regarding the accuracy of additive manufacturing in comparison to conventional casting, specifically for fabrication of complete palatal coverage metal frameworks.Materials and MethodsThree additive manufacturing techniques were tested: selective laser melting (SLM), electron beam melting (EBM), and computer‐aided design/cast (CADcast), with conventional casting as the control. Both the SLM and EBM groups were tested pre‐ and post‐finishing, for a total of six test groups (n = 10/group). A digital master design was used as the standard to which all frameworks were digitally compared by best‐fit analysis, which generated root mean square values using proprietary software. A one‐way ANOVA was conducted to test for statistical differences among materials, followed by a post‐hoc multiple comparison test (Tukey's test HSD). Surface roughness for one framework arbitrarily selected from each group was analyzed using a profilometer.ResultsThere was a significant difference in accuracy among the materials (F = 99.79, p < 0.0001). A post‐hoc Tukey test indicated that CADcast differed significantly from the other five materials (i.e., most accurate, p < 0.01). EBM prefinished and EBM finished were both significantly different from the other materials (i.e., least accurate). Color mapping images help visualize the differences between each framework compared to the master design. The surface roughness values ranged from 22 to 63.5 µm, with CADcast being the smoothest, and EBM prefinished the roughest.ConclusionsCADcast and SLM techniques were as or more accurate than the conventional technique for producing an uncomplicated framework design. Further investigation is recommended regarding the surface roughness of additive manufacturing products and potential biological complications.
Membrane‐based therapeutic plasma exchange in dogs: Prescription, anticoagulation, and metabolic response
Authors: Francey Thierry , Schweighauser Ariane 
Published: May 2019

AbstractBackgroundTherapeutic plasma exchange (TPE) is used increasingly in small animals to remove circulating large molecular products such as antibodies, pathogenic proteins, and protein‐bound toxins. Specific, efficient, and safe protocols need to be developed.Hypothesis/ObjectivesTo describe the technique of membrane‐based TPE, the resulting physiological and metabolic changes, and to define an adequate regional citrate anticoagulation protocol.AnimalsThirty‐four dogs treated with TPE (2011‐2017).MethodsRetrospective review of all TPE treatments performed at the Vetsuisse Faculty, University of Bern, identified through a search of the institutional database for extracorporeal treatments.ResultsSixty‐four treatments were performed, resulting in 1.0 plasma volume exchange (range, 0.4‐1.1). Replacement fluids included fresh frozen plasma (12%‐100% volume), colloids (0%‐52%), human albumin (0%‐41%), and saline (0%‐70%). Anticoagulation was performed with regional citrate (n = 24), systemic heparinization (n = 2), or combined (n = 38). Main relevant laboratory changes included a 24.7% decrease in total proteins (interquartile range, 16.7‐31.4;P < .001), 53% in fibrinogen (−30 to 63;P= .009), 36% in bilirubin (13‐43,P= .02), 9.0% in urea (0.7‐15.7;P < .001), and 4.5% in creatinine (−6.6 to 10.6;P= .006). Citrate accumulation was evidenced in all dogs, more pronounced in those with renal but not with hepatic impairment. Maximal tolerable citrate rates were estimated as 5.5 and 9.0 μmol/kg/min for treatments in dogs with and without renal impairment, respectively. Complications were observed in 22 treatments (34%) and were fatal in 2 dogs.Conclusions and Clinical ImportanceTherapeutic plasma exchange causes metabolic and biochemical alterations. Understanding these effects makes possible to anticipate most complications and to improve safety of the procedure.
Sustained effect of repeated botulinum toxin type A injections in trigeminal neuralgia
Authors: Gorimanipalli Bhavya , Elavarasi Arunmozhimaran , Goyal Vinay , Goyal Chanchal , Shukla Garima , Behari Madhuri 
Published: May 2019

AbstractBackgroundTrigeminal neuralgia is a chronic severely disabling facial pain syndrome, which significantly affects the quality of life of patients. Drugs are effective in controlling pain, but surgery is offered in drug‐refractory cases, which may not be feasible due to lack of availability of neurosurgeons or due to unfavorable risk‐benefit ratio or patient preference. Botulinum neurotoxin is an effective alternative in patients who are drug refractory and not willing for surgery.ObjectivesTo study the safety and efficacy of repeated injections of botulinum neurotoxin in the treatment of drug‐refractory trigeminal neuralgia.MethodologyRetrospective review of all case files was done, and required data were retrieved for analysis.ResultsIn 23 patients, 54 injections of botulinum neurotoxin were given. The pain on VAS decreased from 9.08 ± 1.41 to 1.03 ± 1.69 with P < 0.0001. All patients had >50% relief in pain. The efficacy of injection was comparable in single injection as well as repeated injections group.ConclusionsRepeated injection of botulinum neurotoxin is safe and effective method of treatment in patients who do not want or those who are not fit for surgery.
Reasons for successful clinical outcome following pulmonary vein isolation despite lack of persistent LA‐PV conduction block
Authors: Pandozi Claudio , Lavalle Carlo , Ficili Sabina , Russo Maurizio , Galeazzi Marco , Rio Teresa , Centurion Aznaran Carlos , Malacrida Maurizio , Colivicchi Furio 
Published: May 2019

AbstractThe mechanisms of atrial fibrillation (AF) induction and maintenance, including those involved in paroxysmal atrial fibrillation, are not completely known; this limits our ablation strategies and prevents us from understanding what we are actually doing when performing pulmonary vein isolation. In this report, we focus on the commonly used ablation strategies for AF and question the importance of complete pulmonary vein isolation in achieving lasting success in the ablation of AF. We also discuss in detail the absence of durable pulmonary vein isolation in patients without arrhythmic recurrences after AF ablation and the possibility to cure paroxysmal AF without concomitant pulmonary vein isolation, provocatively questioning the dogma of pulmonary vein isolation as the cornerstone of AF ablation. Finally, a prospective personalized approach in the individual patient is advocated.
Catatonia in patients with anti‐NMDA receptor encephalitis
Authors: Espinola‐Nadurille Mariana , Flores‐Rivera Jose , Rivas‐Alonso Veronica , Vargas‐Cañas Steven , Fricchione Gregory L. , Bayliss Leo , Martinez‐Juarez Iris E. , Hernandez‐Vanegas Laura E. , Martinez‐Hernandez Ruben , Bautista‐Gomez Paola , Solis‐Vivanco Rodolfo , Perez‐Esparza Rodrigo , Bustamante‐Gomez Paula A. , Restrepo‐Martinez Miguel , Ramirez‐Bermudez Jesus 
Published: May 2019

AimThere is a lack of studies related to the frequency, phenomenology, and associated features of catatonic syndrome in patients with anti‐NMDA receptor encephalitis (ANMDARE). This study aimed to measure the frequency of catatonia in this condition and to delineate its particular symptoms.MethodsA prospective study was done with all inpatients who fulfilled the criteria of definite ANMDARE admitted to the National Institute of Neurology and Neurosurgery of Mexico from January 2014 to September 2018. The Bush–Francis Catatonia Rating Scale and Braünig Catatonia Rating Scale were administered at admission.ResultsFifty‐eight patients were included and catatonia was diagnosed in 41 of these patients (70.6%). Immobility, staring, mutism, and posturing were the most frequent catatonic signs. Catatonia was associated with delirium, hallucinations, psychomotor agitation, generalized electroencephalography dysfunction, and previous use of antipsychotics. Mortality was present in 10% of the total sample; it was associated with status epilepticus, and was less frequent in the catatonia group. After immunotherapy, all cases showed a complete recovery from catatonic signs.ConclusionThis systematic assessment of catatonic syndrome shows that it is a frequent feature in patients with ANMDARE as part of a clinical pattern that includes delirium, psychomotor agitation, and hallucinations. The lack of recognition of this pattern may be a source of diagnostic and therapeutic errors, as most physicians associate catatonia with schizophrenia and affective disorders.
A custom made extraoral aid for retaining interim obturator in edentulous patients with bilateral maxillectomy: A report of four patients
Authors: Dhiman Mohit , Shastry Tejomay , Bhandari Sudhir , Singh Sombir , Verma Sanjeev 
Published: May 2019

AbstractIt is a considerable challenge for a prosthodontist to rehabilitate and sustain the prosthesis in edentulous patients with bilateral maxillectomy. Compelling evidence is lacking with respect to the treatment outcome when the maxillary defects are closed surgically in comparison to their prosthetic rehabilitation. Four edentulous male patients, with bilateral maxillectomy defects were referred for prosthodontic intervention to meet their nutritional and speech issues. In the absence of intra oral supporting and retentive structures, it was decided to retain the obturator utilizing extraoral aid to address their functional needs.Customized headgear face‐bow retained obturators were adequately retentive and did serve its purpose well in all four patients. It also gave the liberty to alter retention and refine the prosthesis at will, provided access to the operated site for a quick evaluation of disease recurrence, and was economical to the patients. Considering the encouraging outcome experienced in this special category of individuals, it would be reasonable to believe that the headgear face‐bow assembly has an immense potential to function as a valuable, prudent, and a viable retentive aid for a non‐implant retained obturator in edentulous patients with extensive maxillary defect.
Long‐term outcomes of 54 dogs with tracheal collapse treated with a continuous extraluminal tracheal prosthesis
Authors: Suematsu Masahiro , Suematsu Hiroaki , Minamoto Tomomi , Machida Noboru , Hirao Daiki , Fujiki Makoto 
Published: May 2019

AbstractObjectiveTo describe the surgical placement of a continuous extraluminal tracheal prosthesis (CETP) and report the subsequent postoperative clinical outcomes in dogs with tracheal collapse.Study designRetrospective case series.AnimalsFifty‐four dogs.MethodsMedical records of dogs in which cervical and/or thoracic inlet tracheal collapse was diagnosed and treated by placement of a CETP between 2010 and 2017 were reviewed to evaluate postoperative complications, changes in respiratory function, and survival. Histological examinations of tracheal tissues performed in 2 dogs at 51 and 57 months after surgery were also reviewed.ResultsFifty‐three (98%) dogs survived to discharge. Postoperative complications included laryngeal paralysis (1 dog), disseminated intravascular coagulation (1 dog), and recurrent tracheal collapse (2 dogs). None of the dogs exhibited clinical evidence of tracheal necrosis. Preoperative dry, harsh cough resolved in 87% of the dogs after surgery. Goose honking cough was resolved in 25 of 26 (96%) dogs. Median follow‐up time was 30 months (range, 16 days to 76 months). The survival rate at 36 months was 86% (CI: 75%‐96%). On histological examination in 2 dogs, the tracheal tissue surrounding the prosthesis was well preserved and without evidence of chronic inflammation.ConclusionContinuous extraluminal tracheal prosthesis placement in dogs with tracheal collapse resulted in low postoperative complication rates and good long‐term outcomes.Clinical significanceContinuous extraluminal tracheal prosthesis placement provides a viable alternative surgical option for managing dogs with tracheal collapse.
Diamond and coesite inclusions in detrital garnet of the Saxonian Erzgebirge, Germany
Authors: Schönig Jan , von Eynatten Hilmar , Meinhold Guido , Lünsdorf N. Keno 
Published: May 2019

Abstract
Local occurrences of coesite- and diamond-bearing rocks in the central Erzgebirge (northwestern Bohemian Massif, Germany) reveal ultrahigh-pressure (UHP) metamorphic conditions during the Variscan orogeny. Although UHP metamorphism supposedly affected a wider area, implying that rocks that equilibrated under UHP conditions occur dispersed in large volumes of high-pressure country-rock gneisses, mineralogical evidence is scarce. Here we have applied the new concept of capturing the distribution and characteristics of UHP rocks by analyzing inclusions in detrital garnet. Out of 700 inclusion-bearing garnets from seven modern sand samples from creeks draining the UHP area around the Saidenbach reservoir, we detected 26 garnets containing 46 mainly monomineralic coesite inclusions and 22 garnets containing 41 diamond inclusions. Combining these results with geochemical classification of the host garnets, we show (1) that coesite-bearing rocks are common and comprise eclogites as well as felsic gneisses, (2) that small inclusion size is a necessary precondition for the preservation of monomineralic coesite, and (3) for the first time, that diamond-bearing crustal rocks can be detected by analyzing the detrital record. Our results highlight the potential of this novel application of sedimentary provenance tools to UHP research, and the necessity of looking at the micrometer scale to find evidence in the form of preserved UHP minerals.
Influence of timing of initiation of therapeutic hypothermia on brain MRI and neurodevelopment at 18 months in infants with HIE: a retrospective cohort study
Authors: Guillot Mireille , Philippe Marissa , Miller Elka , Davila Jorge , Barrowman Nicholas James , Harrison Mary-Ann , Ben Fadel Nadya , Redpath Stephanie , Lemyre Brigitte 
Published: May 2019

ObjectiveTo examine the influence of timing of initiation of therapeutic hypothermia (TH) on brain injury on MRI and on neurodevelopmental outcomes at 18 months.DesignRetrospective cohort study.SettingTertiary neonatal intensive care unit in Ontario, Canada.PatientsNinety-one patients with hypoxic ischaemic encephalopathy (HIE) were included, 54 in the early TH group and 37 in the late TH group.InterventionWhole-body hypothermia administered for 72 hours, initiated either before 3 hours of life (early TH) or between 3 and 6 hours of life (late TH).Main outcome measuresBrain injury on MRI after TH (assessed by two neuroradiologists), and neurodevelopmental outcomes at 18 months old.ResultsTH was initiated at a median time of 1.4 hours (early TH) and 4.4 hours (late TH). Sixty-four neonates (early TH=36, late TH=28) survived and completed neurodevelopmental assessment at 18 months. Neonates in the early TH group received more extensive resuscitation than neonates in the late TH group (p=0.0008). No difference was observed between the two groups in the pattern or severity of brain injury on MRI, or in the neurodevelopmental outcomes at 18 months. The non-survivors (n=16) had lower Apgar scores at 10 min, more extensive resuscitation, suffered from more severe HIE and had significantly more abnormal cerebral function monitoring.ConclusionIn this retrospective cohort study, TH initiated early was associated neither with a difference in brain injury on MRI nor better neurodevelopmental outcomes at 18 months.
Association of sex and atrial fibrillation therapies with patient-reported outcomes
Authors: Gleason Kelly Therese , Dennison Himmelfarb Cheryl Renee , Ford Daniel Ernest , Lehmann Harold , Samuel Laura , Jain Sandeep , Naccarelli Gerald , Aggarwal Vikas , Nazarian Saman 
Published: May 2019

ObjectivesWomen report higher atrial fibrillation (AF) symptom severity and receive less AF therapies than their male counterparts. It is understudied if differences in AF therapies received explains sex differences in AF symptom severity. We investigate the impact of sex and AF therapies on patient-reported outcomes.MethodsParticipants were recruited (n=953) across four academic medical centres with an AF diagnosis and age ≥18 years. Patient-reported outcomes (AF symptom severity, AF-related quality of life, functional status and emotional status) were determined by biannual surveys. We performed multiple linear regressions on propensity-matched cohorts to determine the association of AF therapies and sex on patient-reported outcomes.ResultsOur study population (n=953) was 65% male (n=616), 93% white (n=890) and 72 (±10) years old. Individuals receiving rate control therapy reported comparatively lower AF-related quality of life (−7.22, 95% CI −11.51 to –2.92) and poorer functional status (−3.69, 95% CI −5.27 to –2.12). Individuals receiving rhythm control strategies did not report significantly different patient-reported outcomes. Women were more likely to report poorer functional status (−2.63, 95% CI −3.86 to –1.40) and poorer AF-related quality of life, higher anxiety (2.33, 95% CI 1.07 to 3.59), higher symptoms of depression (1.48, 95% CI 0.31 to 2.65) and AF symptom severity (0.29, 95% CI 0.07 to 0.52).ConclusionsFemale sex was associated with comparatively poorer AF symptom severity and quality of life, and this association remained after accounting for AF therapies received. Receiving rate control medication alone was associated with comparatively poorer AF-related quality of life and functional status.
Propensity score-matched analysis of patients with severe aortic stenosis undergoing surgical aortic valve replacement
Authors: Miura Shiro , Yamashita Takehiro , Hanyu Michiya , Kumamaru Hiraku , Shirai Shinichi , Ando Kenji 
Published: May 2019

ObjectiveSevere aortic stenosis (AS) is one of the most serious valve conditions. Patient demography and the aetiology of AS have substantially changed in the past several decades along with a drastic improvement of surgical aortic valve replacement (SAVR) and its associated procedures. Contemporary patients with severe AS have multiple comorbidities and live much longer. We aimed to elucidate the treatment effects of SAVR on long-term outcome in propensity score (PS)-matched and the entire patient populations.MethodsWe retrospectively reviewed 570 patients with severe AS defined as an aortic valve area of 1.0 cm2or less. Systemic differences in 39 baseline characteristics between non-SAVR and SAVR groups were adjusted using PS matching method. The endpoints included all-cause mortality and cardiovascular events that included heart failure, non-fatal stroke, syncope and acute coronary syndrome.ResultsOverall, 55% of the entire population (mean age 78 years; males 41%) were symptomatic. During 3.9 years of the median follow-up, 210 (36%) patients underwent SAVR and 231 (41%) died. Cumulative incidences of mortality and both mortality and cardiovascular events were significantly higher in the non-SAVR group than in the other group (p<0.001, each). Among 101 PS-matched pairs, SAVR correlated with a lower mortality risk (HR 0.35; 95% CI 0.21 to 0.59; p<0.001)) and mortality and cardiovascular events combined (HR 0.62; 95% CI 0.42 to 0.92; p=0.02). However, survival difference between both groups was markedly smaller among asymptomatic patients in the subgroup of matched patients.ConclusionPatients with AS undergoing SAVR exhibit a lower incidence of all-cause mortality and major cardiovascular events than those not undergoing surgical interventions, even after the baseline characteristics are balanced by the PS matching. The correlation between SAVR and survival from cardiovascular events is less evident among asymptomatic patients.