bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new switched off‐line NMPC approach for nonlinear systems with a switching performance index using an extended modal series method
Authors: Sajjadi Samaneh Sadat , Karimpour Ali , Pariz Naser , Jajarmi Amin 
Published: July 2018

SummaryThis paper presents a new switched nonlinear model predictive control (NMPC) approach for continuous‐time affine‐input nonlinear systems with a number of different cost functions where switching occurs between them in order to improve the performance. In this approach, the NMPC‐related nonlinear two‐point boundary value problem derived from Pontryagin's maximum principle is solved by the extended modal series method. The resulting suboptimal control law as to each of the cost functions is feasible and has an explicit form. In order to guarantee closed‐loop stability, certain assumptions are considered in the NMPC literature and in the switched systems literature, such as finding an invariant terminal region and a feasible solution for the NMPC and considering a certain average dwell time for switching signals. In this paper, we consider switching among different cost functions using the average dwell‐time approach. Since, in our proposed method, the NMPC problem solution obtained by the extended modal series method is feasible and since the invariance condition for the terminal region is satisfied, the common assumptions for the stability of the switched NMPC can be established. Furthermore, we show that this method guarantees the stability of the entire closed‐loop system in the presence of unknown persistent disturbances. The applicability and effectiveness of the proposed approach are illustrated by two numerical examples.
Autologous Granulocyte Colony-Stimulating Factor-Mobilized Peripheral Blood CD34 Positive Cell Transplantation for Hemodialysis Patients with Critical Limb Ischemia: A Prospective Phase II Clinical Trial
Authors: Ohtake Takayasu , Mochida Yasuhiro , Ishioka Kunihiro , Oka Machiko , Maesato Kyoko , Moriya Hidekazu , Hidaka Sumi , Higashide Satoshi , Ioji Tetsuya , Fujita Yasuyuki , Kawamoto Atsuhiko , Fukushima Masanori , Kobayashi Shuzo 
Published: July 2018

Abstract
Critical limb ischemia (CLI) is a devastating disease in patients undergoing hemodialysis (HD). Based on the unsatisfactory results of autologous mononuclear cell transplantation for patients with CLI undergoing HD, we conducted a phase II clinical trial to evaluate the safety and efficacy of granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood-derived autologous purified CD34 positive (CD34+) cell transplantation for CLI in patients undergoing HD. Six patients with CLI (two with Rutherford category 4 and four with Rutherford category 5) were enrolled. As for primary endpoint, there were no major adverse events related to this therapy. As for efficacy, the amputation-free survival rate was 100% at 1 year after cell therapy. Both rest pain scale and ulcer size were significantly improved as early as 4 weeks after therapy compared with baseline (p &lt; .01), and three out of five ulcers completely healed within 12 weeks after cell transplantation. Clinical severity, including Fontaine scale and Rutherford category, significantly improved at 24 weeks after cell transplantation (p &lt; .05), and further improved at 52 weeks (p &lt; .01) compared with baseline. The improvement rate from CLI stage to non-CLI stage was 83.3% at 52 weeks. Toe skin perfusion pressure and absolute claudication distance were also significantly improved. In conclusion, G-CSF-mobilized peripheral blood CD34+ cell transplantation was safe, feasible, and effective for patients with CLI undergoing HD.
Preparation of 5‐Substituted‐1H‐Tetrazoles Catalyzed by MOFs via Two Strategies: Direct Condensation of Aryl Nitriles with Sodium Azide, and Tri‐Component Reaction Method
Authors: Tourani Hesam , Naimi‐Jamal M. Reza , Dekamin Mohammad G. 
Published: July 2018

AbstractVarious 5‐substituted‐1H‐tetrazoles were synthesized via two strategies; direct [3+2] cycloaddition of substituted aryl nitriles with sodium azide, and tri‐component reaction of aldehydes, hydroxylamine hydrochloride with sodium azide in dimethylformamide (DMF) by applying M2(BDC)2(DABCO) [M: Cu, Co and Ni, BDC=1, 4‐benzenedicarboxylic acid, and DABCO= 1,4‐diazabicyclo[2.2.2]octane] as heterogeneous catalyst. Short reaction time, high yield, totally straightforward procedure and easy work‐up, as well as preparing tetrazole derivatives via relatively cheap and easily available aldehydes (in three‐component method) are some beneficial features of mentioned methodologies. It was found that among three studied transition metals, copper has a unique advantage over other metals in formation of the desired product.
Self‐Assembly of CoPt Magnetic Nanoparticle Arrays and its Underlying Forces
Authors: Bian Baoru , Chen Guoxin , Zheng Qiang , Du Juan , Lu Huanming , Liu J. Ping , Hu Yong , Zhang Zhidong 
Published: July 2018

AbstractNanoparticles covered with surfactants are often used to study particle motion patterns and self‐assembly processes in solutions. Surfactants have influence on the interparticle interactions and therefore on the particle motion tracks and final patterns. In this study, CoPt nanoparticles are synthesized in aqueous solution without any surfactant. In situ transmission electron microscopy observation is performed to monitor the self‐assemble process. Two types of magnetic nanoparticle superlattice arrays are formed: hexagonal equal distance superlattice arrays when particle size is 3 nm, and tight unequal distance superlattice arrays when particle size is 4.5 nm. It is interesting to observe that two small arrays merge into a large one through rotational and translational movements. A Monte Carlo simulation is carried out which successfully restores the whole process. It is identified that the underlying forces are van der Waals and magnetic dipolar interactions. The latter is responsible for orientation of each particle during the whole process. This investigation leads to a better understanding of the formation mechanism of magnetic nanoparticle superlattice arrays.
Highly Dispersed Copper Nanoparticles Supported on Activated Carbon as an Efficient Catalyst for Selective Reduction of Vanillin
Authors: Fan Ruoyu , Chen Chun , Han Miaomiao , Gong Wanbing , Zhang Haimin , Zhang Yunxia , Zhao Huijun , Wang Guozhong 
Published: July 2018

AbstractHighly dispersed copper nanoparticles (Cu NPs) supported on activated carbon (AC) are effectively synthesized by one‐pot carbothermal method at temperature range of 400–700 °C. The X‐ray diffraction, transmission electron microscopy, X‐ray photoelectron spectroscopy, and Brunauer–Emmett–Teller analysis reveal that Cu NPs with diameters of 20–30 nm are evenly anchored in carbon matrix. The 15 wt%‐Cu/AC‐600 catalyst (derived at 600 °C) exhibits best bifunctional catalysis of aqueous‐phase hydrodeoxygenation (HDO) and organic‐phase transfer‐hydrogenation reaction (THR) to selectively transform vanillin to 2‐methoxy‐4‐methylphenol (MMP). In HDO of vanillin, the as‐prepared catalyst achieves a 99.9% vanillin conversion and 93.2% MMP selectivity under 120 °C, 2.0 MPa H2 within 5 h. Meanwhile, near‐quantitative vanillin conversion and 99.1% MMP selectivity are also obtained under 180 °C within 5 h in THR of vanillin by using 2‐propanol as hydrogen donor. The transforming pathways of vanillin are also proposed: vanillin is transformed into MMP via intermediate of 4‐hydroxymethyl‐2‐methoxyphenol in HDO case and by direct hydrogenolysis of vanillin in THR course. More importantly, the activity and the selectivity do not change after 5 cycles, indicating the catalyst has excellent stability. The Cu‐based catalyst is relatively cheap and preparation method is facile, green, and easy scale‐up, thus achieving a low‐cost transformation of biomass to bio‐oils and chemicals.
An Eocene paraclupeid fish (Teleostei, Ellimmichthyiformes) from Bolca, Italy: the youngest marine record of double‐armoured herrings
Authors: Marramà Giuseppe , Bannikov Alexandre F. , Kriwet Jürgen , Carnevale Giorgio 
Published: July 2018

AbstractA new double‐armoured herring of the clupeomorph order Ellimmichthyiformes, Eoellimmichthys superstes gen. et sp. nov., is described herein based on a single partially complete specimen from the early Eocene Pesciara site of the Bolca Konservat‐Lagerstätte, north‐eastern Italy. The fossil documented herein exhibits a unique combination of features (e.g. ornamentation of the skull bones; medial fusion of the contralateral halves of the neural arches of abdominal vertebrae; teeth on endopterygoid, parhypural fused to the first preural centrum; presence of a short series of 6 (or 7) predorsal scutes increasing in size posteriorly; postpelvic scutes bearing very prominent spines), which clearly supports its recognition as a new genus and species of the family Paraclupeidae. Evidence is provided to show that Eoellimmichthys gen. nov. is most closely related phylogenetically to the Early Cretaceous genus Ellimmichthys. The new taxon described herein represents the youngest marine occurrence of the family Paraclupeidae and, more generally, of the order Ellimmichthyiformes, suggesting that the shallow marine settings of the Tethys might have favoured the persistence of certain fish lineages that were severely affected by the end‐Cretaceous mass extinction.
Spatial and temporal trends of nitrate, chloride, and bromide concentration in an alluvial aquifer, North‐Central Texas, USA
Authors: Hudak Paul F. 
Published: July 2018

AbstractThe Seymour aquifer consists of unconfined outcrops of sand and gravel in a semiarid, agricultural region of north‐central Texas in the United States of America. Most water samples collected from the aquifer in 2015 had nitrate concentrations above the drinking water standard of 44.3 milligrams per liter (mg/L). Generally, areas with high nitrate concentration in 2010 remained high in 2015, although the median dropped by 3.9 mg/L. The largest decreases in nitrate concentration—up to 97 mg/L (60%)—were observed in wells with depths less than the median of 13.1 meters (m). However, other wells, including depths above and below the median, showed increases in nitrate concentration of up to 40 mg/L (42%). In 2015, chloride concentrations in six wells exceeded the secondary contaminant level of 250 mg/L, and one well had a chloride concentration of 1,810 mg/L. Past and ongoing agricultural practices, including cultivation of native grassland, application of fertilizer, and irrigation with nitrate‐contaminated groundwater, help sustain overall high nitrate concentrations within the aquifer. Local conditions governing nitrogen inputs and dilution result in significant improvement or worsening of the nitrate problem over relatively short timeframes. The pumping of groundwater from the aquifer may facilitate mixing with groundwater of increased salinity that has been affected by the dissolution of evaporites in underlying Permian bedrock.
Mapping of novel salt tolerance QTL in an Excalibur × Kukri doubled haploid wheat population
Authors: Asif Muhammad A. , Schilling Rhiannon K. , Tilbrook Joanne , Brien Chris , Dowling Kate , Rabie Huwaida , Short Laura , Trittermann Christine , Garcia Alexandre , Barrett-Lennard Edward G. , Berger Bettina , Mather Diane E. , Gilliham Matthew , Fleury Delphine , Tester Mark , Roy Stuart J. , Pearson Allison S. 
Published: July 2018

Abstract
Key message
Novel QTL for salinity tolerance traits have been detected using non-destructive and destructive phenotyping in bread wheat and were shown to be linked to improvements in yield in saline fields.

Abstract
Soil salinity is a major limitation to cereal production. Breeding new salt-tolerant cultivars has the potential to improve cereal crop yields. In this study, a doubled haploid bread wheat mapping population, derived from the bi-parental cross of Excalibur × Kukri, was grown in a glasshouse under control and salinity treatments and evaluated using high-throughput non-destructive imaging technology. Quantitative trait locus (QTL) analysis of this population detected multiple QTL under salt and control treatments. Of these, six QTL were detected in the salt treatment including one for maintenance of shoot growth under salinity (QG(1–5).asl-7A), one for leaf Na+ exclusion (QNa.asl-7A) and four for leaf K+ accumulation (QK.asl-2B.1, QK.asl-2B.2, QK.asl-5A and QK:Na.asl-6A). The beneficial allele for QG(1–5).asl-7A (the maintenance of shoot growth under salinity) was present in six out of 44 mainly Australian bread and durum wheat cultivars. The effect of each QTL allele on grain yield was tested in a range of salinity concentrations at three field sites across 2 years. In six out of nine field trials with different levels of salinity stress, lines with alleles for Na+ exclusion and/or K+ maintenance at three QTL (QNa.asl-7A, QK.asl-2B.2 and QK:Na.asl-6A) excluded more Na+ or accumulated more K+ compared to lines without these alleles. Importantly, the QK.asl-2B.2 allele for higher K+ accumulation was found to be associated with higher grain yield at all field sites. Several alleles at other QTL were associated with higher grain yields at selected field sites.
Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma
Authors: Ng Kimmie , Hendifar Andrew , Starodub Alexander , Chaves Jorge , Yang Yingsi , Koh Brian , Barbie David , Hahn William C. , Fuchs Charles S. 
Published: July 2018

Summary
Purpose Preclinical evidence suggests the importance of Janus activating kinase (JAK) and TANK-binding kinase 1 (TBK1) in pancreatic ductal adenocarcinoma (PDAC). We evaluated the safety and efficacy of momelotinib (MMB), a JAK1/2 inhibitor with additional activity against TBK1, plus albumin-bound paclitaxel + gemcitabine (nab-P + G), in patients with previously untreated metastatic PDAC. Experimental Design Patients were enrolled into five cohorts of increasing doses of MMB between 100 and 200 mg administered once or twice daily in combination with nab-P + G in 28-day cycles to determine maximum tolerated dose (MTD). Safety, efficacy, pharmacokinetics, and pharmacodynamics were assessed for all patients. Results Twenty-five patients were enrolled. Dose-limiting toxicities of Grade 3 diarrhea occurred in 1 patient each in the 100 and 200 mg MMB once-daily dose groups. MTD was not reached. The 200 mg MMB twice-daily was the maximum administered dose. Objective response rate was 28% (all partial responses), and 13 (52%) patients had a best response of stable disease. The most common adverse events (AEs) were fatigue (80%), nausea (76%), and anemia (68%). Grade 3 or 4 AEs, most commonly neutropenia (32%), were reported by 88% of patients, of which 44% were considered related to MMB. Pharmacokinetic analyses showed MMB concentrations were too low for TBK1 inhibition. Conclusions MMB was safe and well tolerated in combination with nab-P + G. As no OS or PFS benefit vs nab-P + G was apparent in context of suboptimal engagement of the target TBK1, this study does not support further development of MMB as a first-line therapy in pancreatic cancer.
The intergenerational transmission of trait emotional intelligence: The mediating role of parental autonomy support and psychological control
Authors: Costa Sebastiano , Barberis Nadia , Gugliandolo Maria Cristina , Larcan Rosalba , Cuzzocrea Francesca 
Published: July 2018

ABSTRACTIntroductionTrait emotional intelligence (trait EI) is a relevant construct that could promote positive development in adolescents and may predict a number of affect‐related outcomes. However, studies focused on its antecedents are still scarce. The main aim of this study is to examine the intergenerational transmission of trait EI from parents to adolescents and the mediating role of parental autonomy support and psychological control.MethodsOur sample was comprised of 152 cohabiting families, with adolescents (75 males and 77 females) between 16 and 17 years old (M = 16.45; SD = 0.50).ResultsResults suggested that paternal and maternal trait EI positively predicted paternal and maternal autonomy support and psychological control, and adolescent trait EI was predicted by maternal trait EI, adolescent perception of parental autonomy support and adolescent perception of parental psychological control. Adolescent perception of parental autonomy support and adolescent perception of parental psychological control were shown to act as mediators between adolescents' trait EI and paternal and maternal trait EI.ConclusionsThe results extend the literature on the role of parents in the development of trait EI and confirm the relevance of trait EI for affect‐related outcomes.
Stability analysis of non-isothermal fibre spinning of polymeric solutions
Authors: Gupta Karan , Chokshi Paresh 
Published: July 2018

The stability of fibre spinning flow of a polymeric fluid is analysed in the presence of thermal effects. The spinline is modelled as a one-dimensional slender-body filament of the entangled polymer solution. The previous study (Gupta & Chokshi,J. Fluid Mech., vol. 776, 2015, pp. 268–289) analysed linear and nonlinear stability behaviour of an isothermal extensional flow in the air gap during the fibre spinning process. The present study extends the analysis to take in to account the non-isothermal spinning flow in which the spinline loses heat by convection to the surrounding air as well as by solvent evaporation. The nonlinear rheology of the polymer solution is described using the eXtended Pom-Pom (XPP) model. The non-isothermal effects influence the rheology of the fluid through viscosity, which is taken to be temperature and concentration dependent. The linear stability analysis is carried out to obtain the draw ratio for the onset of instability, known as the draw resonance, and a stability diagram is constructed in the$DR_{c}{-}De$plane.$DR_{c}$is the critical draw ratio, and$De$is the flow Deborah number. The enhancement in viscosity driven by spinline cooling leads to postponement in the onset of draw resonance, indicating the stabilising role of non-isothermal effects. Weakly nonlinear stability analysis is also performed to reveal the role of nonlinearities in the finite amplitude manifold in the vicinity of the flow transition point. For low to moderate Deborah numbers, the bifurcation is supercritical, and the flow attains an oscillatory state with an equilibrium amplitude post-transition when$DR>DR_{c}$. The equilibrium amplitude of the resonating state is found to be smaller when non-isothermal effects are incorporated in comparison to the isothermal spinning flow. For very fast flows in the regime of high Deborah numbers, the finite amplitude manifold crosses over to a subcritical state. In this limit, the nonlinearities render the flow unstable even in the linearly stable regime of$DR<DR_{c}$.
Stokes flow of vesicles in a circular tube
Authors: Barakat Joseph M. , Shaqfeh Eric S. G. 
Published: July 2018

The inertialess motion of lipid-bilayer vesicles flowing through a circular tube is investigated via direct numerical simulation and lubrication theory. A fully three-dimensional boundary integral equation method, previously used to study unbounded and wall-bounded Stokes flows around freely suspended vesicles, is extended to study the hindered mobility of vesicles through conduits of arbitrary cross-section. This study focuses on the motion of a periodic train of vesicles positioned concentrically inside a circular tube, with particular attention given to the effects of tube confinement, vesicle deformation and membrane bending elasticity. When the tube diameter is comparable to the transverse dimension of the vesicle, axisymmetric lubrication theory provides an approximate solution to the full Stokes-flow problem. By combining the present numerical results with a previously reported asymptotic theory (Barakat & Shaqfeh, J. Fluid Mech., vol. 835, 2018, pp. 721–761), useful correlations are developed for the vesicle velocity $U$ and extra pressure drop $\unicode[STIX]{x0394}p^{+}$. When bending elasticity is relatively weak, these correlations are solely functions of the geometry of the system (independent of the imposed flow rate). The prediction of Barakat & Shaqfeh (2018) supplies the correct limiting behaviour of $U$ and $\unicode[STIX]{x0394}p^{+}$ near maximal confinement, whereas the present study extends this result to all regimes of confinement. Vesicle–vesicle interactions, shape transitions induced by symmetry breaking, and unsteadiness introduce quantitative changes to $U$ and $\unicode[STIX]{x0394}p^{+}$. By contrast, membrane bending elasticity can qualitatively affect the hydrodynamics at sufficiently low flow rates. The dependence of $U$ and $\unicode[STIX]{x0394}p^{+}$ on the membrane bending stiffness (relative to a characteristic viscous stress scale) is found to be rather complex. In particular, the competition between viscous forces and bending forces can hinder or enhance the vesicle’s mobility, depending on the geometry and flow conditions.
The importance of phospholipids combined with long-chain PUFA in formulated diets for pikeperch (Sander lucioperca) larvae
Authors: Lund Ivar , El Kertaoui Najlae , Izquierdo Marisol S. , Dominguez David , Hansen Benni W. , Kestemont Patrick 
Published: July 2018

AbstractDietary phosphoglycerides andn-3 long-chain PUFA (LC-PUFA) play important functions in the development of pikeperch (Sander lucioperca) larvae. This study aimed to determine optimal dietary levels of soyabean lecithin (SBL)-derived phospholipids (PL) in starter feeds for pikeperch larvae 10–30 d post-hatch (DPH) and examine performance and ontogeny by additional supplementation ofn-3 LC-PUFA in the form of Algatrium DHA 70 (glyceride product; 660–700 mg/g DHA; EPA 60–75 mg/g). In total, six isoproteic and isoenergetic extruded diets were formulated with increasing levels of PL (3·7, 8·3 or 14·5 % wet weight (w.w.), respectively); however, three of the diets were supplemented with three levels of Algatrium DHA 70 (0·6, 2·0 or 3·4 %, respectively). Liver proteomic analyses of larvae at 30 DPH were included for effects of PL and primarily DHA on performance, physiological expression and interactions in larval proteins. In addition, bone anomalies, digestive enzymatic activity, candidate gene expression and skeleton morphogenesis were examined. Results confirmed the importance of dietary PL levels of at least 8·2 % w.w., and an additional beneficiary effect of supplementation with DHA plus EPA. Thus, combined supplementation of SBL (up to 14·51 % w.w. PL) andn-3 LC-PUFA (1·004 % DM DHA and 0·169 % DM EPA) in the form of TAG resulted in highest growth and lowest incidence of anomalies, improved digestive enzyme activity and had differential effect on liver proteomics. The results denote that essential fatty acids can be supplemented as TAG to have beneficial effects in pikeperch larvae development.