bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nucleic acids and analogs for bone regeneration
Authors: Zhang Yuxin , Ma Wenjuan , Zhan Yuxi , Mao Chenchen , Shao Xiaoru , Xie Xueping , Wei Xiawei , Lin Yunfeng 
Published: December 2018

AbstractWith the incidence of different bone diseases increasing, effective therapies are needed that coordinate a combination of various technologies and biological materials. Bone tissue engineering has also been considered as a promising strategy to repair various bone defects. Therefore, different biological materials that can promote stem cell proliferation, migration, and osteoblastic differentiation to accelerate bone tissue regeneration and repair have also become the focus of research in multiple fields. Stem cell therapy, biomaterial scaffolds, and biological growth factors have shown potential for bone tissue engineering; however, off-target effects and cytotoxicity have limited their clinical use. The application of nucleic acids (deoxyribonucleic acid or ribonucleic acid) and nucleic acid analogs (peptide nucleic acids or locked nucleic acids), which are designed based on foreign genes or with special structures, can be taken up by target cells to exert different effects such as modulating protein expression, replacing a missing gene, or targeting specific gens or proteins. Due to some drawbacks, nucleic acids and nucleic acid analogs are combined with various delivery systems to exert enhanced effects, but current studies of these molecules have not yet satisfied clinical requirements. In-depth studies of nucleic acid or nucleic acid analog delivery systems have been performed, with a particular focus on bone tissue regeneration and repair. In this review, we mainly introduce delivery systems for nucleic acids and nucleic acid analogs and their applications in bone repair and regeneration. At the same time, the application of conventional scaffold materials for the delivery of nucleic acids and nucleic acid analogs is also discussed.
Interplay between pulsation, mass loss, and third dredge-up: More about Miras with and without technetium
Authors: Uttenthaler S. , McDonald I. , Bernhard K. , Cristallo S. , Gobrecht D. 
Published: December 2018

Context. We follow-up on a previous finding that AGB Mira variables containing the third dredge-up indicator technetium (Tc) in their atmosphere form a different sequence of K − [22] colour as a function of pulsation period than Miras without Tc. A near- to mid-infrared colour such as K − [22] is a good probe for the dust mass-loss rate of the stars. Contrary to what might be expected, Tc-poor Miras show redder K − [22] colours (i.e. higher dust mass-loss rates) than Tc-rich Miras at a given period.
Aims. Here, the previous sample is extended and the analysis is expanded towards other colours and dust spectra. The most important aim is to investigate if the same two sequences can be revealed in the gas mass-loss rate.
Methods. We analysed new optical spectra and expanded the sample by including more stars from the literature. Near- and mid-IR photometry and ISO dust spectra of our stars were investigated where available. Literature data of gas mass-loss rates of Miras and semi-regular variables were collected and analysed.
Results. Our results show that Tc-poor Miras are redder than Tc-rich Miras in a broad range of the mid-IR, suggesting that the previous finding based on the K − [22] colour is not due to a specific dust feature in the 22 μm band. We establish a linear relation between K − [22] and the gas mass-loss rate. We also find that the 13 μm feature disappears above K − [22]≃2.17 mag, corresponding to Ṁg ∼ 2.6 × 10−7 M⊙ yr−1. No similar sequences of Tc-poor and Tc-rich Miras in the gas mass-loss rate vs. period diagram are found, most probably owing to limitations in the available data.
Conclusions. Different hypotheses to explain the observation of two sequences in the P vs. K − [22] diagram are discussed and tested, but so far, none of them convincingly explains the observations. Nevertheless, we might have found an hitherto unknown but potentially important process influencing mass loss on the TP-AGB.
Stellar mass spectrum within massive collapsing clumps
Authors: Lee Yueh-Ning , Hennebelle Patrick 
Published: December 2018

Context. The stellar mass spectrum is an important property of the stellar cluster and a fundamental quantity to understand our Universe. The fragmentation of diffuse molecular cloud into stars is subject to physical processes such as gravity, turbulence, thermal pressure, and magnetic field.
Aims. The final mass of a star is believed to be a combined outcome of a virially unstable reservoir and subsequent accretion. We aim to clarify the roles of different supporting energies, notably the thermal pressure and magnetic field, in determining the stellar mass.
Methods. Following our previous studies, we performed a series of numerical experiments of stellar cluster formation inside an isolated molecular clump. We investigated whether any characteristic mass is introduced into the fragmentation processes by changing the effective equation of state (EOS) of the diffuse gas, that is to say gas whose density is below the critical density at which dust becomes opaque to its radiation, and the strength of the magnetic field.
Results. The EOS of the diffuse gas, including the bulk temperature and polytropic index, does not significantly affect the shape of the stellar mass spectrum. The presence of magnetic field slightly modifies the shape of the mass spectrum only when extreme values are applied.
Conclusions. This study confirms that the peak of the initial mass function is primarily determined by the adiabatic high-density end of the EOS that mimics the radiation inside the high-density gas. Furthermore, the shape of the mass spectrum is mostly sensitive to the density PDF and the magnetic field likely only a secondary role. In particular, we stress that the Jeans mass at the mean cloud density and at the critical density are not responsible for setting the peak.
The magnetic field structure in CTA 102 from high-resolution mm-VLBI observations during the flaring state in 2016–2017
Authors: Casadio Carolina , Marscher Alan P. , Jorstad Svetlana G. , Blinov Dmitry A. , MacDonald Nicholas R. , Krichbaum Thomas P. , Boccardi Biagina , Traianou Efthalia , Gómez José L. , Agudo Iván , Sohn Bong-Won , Bremer Michael , Hodgson Jeffrey , Kallunki Juha , Kim Jae-Young , Williamson Karen E. , Zensus J. Anton 
Published: December 2018

Context. Investigating the magnetic field structure in the innermost regions of relativistic jets is fundamental to understanding the crucial physical processes giving rise to jet formation, as well as to their extraordinary radiation output up toγ-ray energies.Aims. We study the magnetic field structure of the quasar CTA 102 with 3 and 7 mm VLBI polarimetric observations, reaching an unprecedented resolution (∼50μas). We also investigate the variability and physical processes occurring in the source during the observing period, which coincides with a very active state of the source over the entire electromagnetic spectrum.Methods. We perform the Faraday rotation analysis using 3 and 7 mm data and we compare the obtained rotation measure (RM) map with the polarization evolution in 7 mm VLBA images. We study the kinematics and variability at 7 mm and infer the physical parameters associated with variability. From the analysis ofγ-ray and X-ray data, we compute a minimum Doppler factor value required to explain the observed high-energy emission.Results. Faraday rotation analysis shows a gradient in RM with a maximum value of ∼6 × 104rad m−2and intrinsic electric vector position angles (EVPAs) oriented around the centroid of the core, suggesting the presence of large-scale helical magnetic fields. Such a magnetic field structure is also visible in 7 mm images when a new superluminal component is crossing the core region. The 7 mm EVPA orientation is different when the component is exiting the core or crossing a stationary feature at ∼0.1 mas. The interaction between the superluminal component and a recollimation shock at ∼0.1 mas could have triggered the multi-wavelength flares. The variability Doppler factor associated with such an interaction is large enough to explain the high-energy emission and the remarkable optical flare occurred very close in time.
A timeline for massive star-forming regions via combined observation of o-H2D+ and N2D+
Authors: Giannetti A. , Bovino S. , Caselli P. , Leurini S. , Schleicher D. R. G. , Körtgen B. , Menten K. M. , Pillai T. , Wyrowski F. 
Published: December 2018

Context. In cold and dense gas prior to the formation of young stellar objects, heavy molecular species (including CO) are accreted onto dust grains. Under these conditions H3+ and its deuterated isotopologues become more abundant, enhancing the deuterium fraction of molecules such as N2H+ that are formed via ion-neutral reactions. Because this process is extremely temperature sensitive, the abundance of these species is likely linked to the evolutionary stage of the source.
Aims. We investigate how the abundances of o-H2D+ and N2D+ vary with evolution in high-mass clumps.
Methods. We observed with APEX the ground-state transitions of o-H2D+ near 372 GHz, and N2D+(3–2) near 231 GHz for three massive clumps in different evolutionary stages. The sources were selected within the G351.77–0.51 complex to minimise the variation of initial chemical conditions, and to remove distance effects. We modelled their dust continuum emission to estimate their physical properties, and also modelled their spectra under the assumption of local thermodynamic equilibrium to calculate beam-averaged abundances.
Results. We find an anticorrelation between the abundance of o-H2D+ and that of N2D+, with the former decreasing and the latter increasing with evolution. With the new observations we are also able to provide a qualitative upper limit to the age of the youngest clump of about 105 yr, comparable to its current free-fall time.
Conclusions. We can explain the evolution of the two tracers with simple considerations on the chemical formation paths, depletion of heavy elements, and evaporation from the grains. We therefore propose that the joint observation and the relative abundance of o-H2D+ and N2D+ can act as an efficient tracer of the evolutionary stages of the star-formation process.
Thromboembolic Disorders during Pregnancy: Cardiologist Perspective
Authors: Hegde Anupama 
Published: December 2018

AbstractThe hematologic changes which occur during pregnancy make it a hypercoagulable state. Various factors such as hereditary thrombophilia, obesity, etc. increase the risk of venous thromboembolism in these patients. Though the prevalence is low, it can contribute to significant mortality and morbidity. Deep vein thrombosis is the most common type of venous thromboembolism and pulmonary embolism can sometimes be fatal. Various diagnostic modalities like compression duplex ultrasound of leg veins, echo, ventilation-perfusion scan, and computed tomographic pulmonary angiogram can help in diagnosis. Proper treatment can improve both maternal and fetal outcome.
Long-Term Cardiovascular Effects of Pregnancy-Related Disorders
Authors: Maddury Jyotsna , Achukatla Kumar 
Published: December 2018

AbstractUsually, pregnancy-elated effects and changes in the different organs terminate after delivery or maybe within 6 months. Long-term effect of complicated pregnancies leading to long-term cardiovascular and other diseases was recognized long back. With the accumulating evidence with many landmark studies, it became mandatory to have pregnancy heart team approach not only to manage during pregnancy and peripartum period but also to monitor future events and educate the pregnant women about the modification of cardiovascular risks for prevention of anticipated events. In this review, more importance is given to risk-stratify these women with complicated pregnancy and recommendation to prevent the long-term effects.
Hypertensive Disorders in Pregnancy
Authors: Nemani Lalita 
Published: December 2018

Abstract
Hypertension in pregnancy is defined as systolic blood pressure (SBP) ≥ 140 mm Hg or diastolic blood pressure (DBP) ≥ 90 mm Hg or both on two different occasions at least 6 hours apart. Severe hypertension is SBP ≥ 160 mm Hg or DBP ≥ 110 mm Hg. Hypertension is the most common medical problem in pregnancy and one of the major causes of maternal and perinatal mortality and morbidity. Hypertensive disorders in pregnancy (HDP) are classified as (1) chronic hypertension, (2) chronic hypertension with superimposed preeclampsia, (3) preeclampsia-eclampsia, and (4) gestational hypertension. HDP contributes to increased risk of hypertension, stroke, and maternal cardiovascular disease (CVD) in later life. HDP can be considered as a failed cardiovascular stress test identifying women susceptible to CVD in later life. Further research is required to identify the mechanisms in HDP that contribute to CVD in later life so as to initiate appropriate prevention measures.
Small-scale urban agriculture results in high yields but requires judicious management of inputs to achieve sustainability
Authors: McDougall Robert , Kristiansen Paul , Rader Romina 
Published: December 2018

Significance
Growing food in cities for human consumption could be one means of increasing global food supply in the face of rising population growth and global food security concerns. While previous studies have shown that urban agricultural systems are productive, few studies provide yield figures that incorporate data on the inputs used to achieve the outputs. Across 13 urban community gardens, we show that yields were nearly twice the yield of typical Australian commercial vegetable farms. However, economic and emergy (embodied energy) analyses indicated they were relatively inefficient in their use of material and labor resources. Balancing the sustainability of urban food production with the cost of inputs is important to determine the trade-offs required to achieve high yields.
Linear variational principle for Riemann mappings and discrete conformality
Authors: Dym Nadav , Slutsky Raz , Lipman Yaron 
Published: December 2018

Significance
Computing conformal (angle-preserving) mappings between domains is a central task in discrete differential geometry, which has found many applications in morphology, medical imaging, computer graphics and vision, and related fields. In this paper we show that by choosing a suitable target domain, computing conformal mappings becomes a linear problem. As a result conformal mappings can be computed robustly and efficiently.
Cooperative subunit dynamics modulate p97 function
Authors: Huang Rui , Ripstein Zev A. , Rubinstein John L. , Kay Lewis E. 
Published: December 2018

Significance
Mutations in the highly conserved hexameric p97 enzyme are associated with a series of diseases affecting muscle, bone, and brain, and have been linked to changes to the orientation of the N-terminal domain (NTD) in each p97 subunit. Although studies have focused on p97 constructs where all protomers are WT or all contain a disease-causing mutation, a strong body of evidence suggests that p97 molecules are heterogeneous, containing a mixture of these subunits in patients. We have used solution NMR to study such heterohexameric structures, showing that the NTD conformation of a disease mutant can be somewhat remedied by WT neighbors, leading to a partial restoration of interactions with adaptor molecules. The mechanism of this allosteric process is investigated.
miRNAs 484 and 210 regulate Pax-5 expression and function in breast cancer cells
Authors: Harquail Jason , LeBlanc Nicolas , Ouellette Rodney J , Robichaud Gilles A 
Published: December 2018

AbstractRecent studies have enabled the identification of important factors regulating cancer progression, such as paired box gene 5 (Pax-5). This transcription factor has consistently been associated to B-cell cancer lesions and more recently solid tumors including breast carcinoma. Although Pax-5 downstream activity is relatively well characterized, aberrant Pax-5 expression in a cancer-specific context is poorly understood. To investigate the regulation of Pax-5 expression, we turned to micro RNAs (miRNAs), small non-coding RNA molecules that regulate key biological processes. Extensive studies show that miRNA deregulation is prevalent in cancer lesions. In this study, we aim to elucidate a causal link between differentially expressed miRNAs in cancer cells and their putative targeting of Pax-5-dependent cancer processes. Bioinformatic prediction tools indicate that miRNAs 484 and 210 are aberrantly expressed in breast cancer and predicted to target Pax-5 messenger RNA (mRNA). Through conditional modulation of these miRNAs in breast cancer cells, we demonstrate that miRNAs 484 and 210 inhibit Pax-5 expression and regulate Pax-5-associated cancer processes. In validation, we show that these effects are probably caused by direct miRNA/mRNA interaction, which are reversible by Pax-5 recombinant expression. Interestingly, miRNAs 484 and 210, which are both overexpressed in clinical tumor samples, are also modulated during epithelial–mesenchymal transitioning and hypoxia that correlate inversely to Pax-5 expression. This is the first study demonstrating the regulation of Pax-5 expression and function by non-coding RNAs. These findings will help us better understand Pax-5 aberrant expression within cancer cells, creating the possibility for more efficient diagnosis and treatments for cancer patients.
Atrial mechanics and their prognostic impact in Takotsubo syndrome: a cardiovascular magnetic resonance imaging study
Authors: Backhaus Sören J , Stiermaier Thomas , Lange Torben , Chiribiri Amedeo , Uhlig Johannes , Freund Anne , Kowallick Johannes T , Gertz Roman J , Bigalke Boris , Villa Adriana , Lotz Joachim , Hasenfuß Gerd , Thiele Holger , Eitel Ingo , Schuster Andreas 
Published: December 2018

AbstractAimsThe exact pathophysiology of Takotsubo syndrome (TTS) remains not fully understood with most studies focussing on ventricular pathology. Since atrial involvement may have a significant role, we assessed the diagnostic and prognostic potential of atrial cardiovascular magnetic resonance feature tracking (CMR-FT) in TTS.Methods and resultsThis multicentre study recruited 152 TTS patients who underwent CMR on average within 3 days after hospitalization. Reservoir [total strain εs and peak positive strain rate (SR) SRs], conduit (passive strain εe and peak early negative SRe), and booster pump function (active strain εa and peak late negative SRa) were assessed in a core laboratory. Results were compared with 21 control patients with normal biventricular function. A total of 20 patients underwent follow-up CMR (median 3.5 months, interquartile range 3–5). All patients were approached for general follow-up. Left atrial (LA) but not right atrial (RA) reservoir and conduit function were impaired during the acute phase (εs: P = 0.043, εe: P < 0.001, SRe: P = 0.047 vs. controls) and recovered until follow-up (εs: P < 0.001, SRs: P = 0.04, εe: P = 0.001, SRe: P = 0.04). LA and RA booster pump function were increased in the acute setting (LA-εa: P = 0.045, SRa: P = 0.002 and RA-εa: P = 0.004, SRa: P = 0.002 vs. controls). LA-εs predicted mortality [hazard ratio 1.10, 95% confidence interval (CI) 1.01–1.20; P = 0.037] irrespectively of established cardiovascular risk factors (P = 0.019, multivariate analysis) including left ventricular ejection fraction (LVEF) (area under the curve 0.71, 95% CI 0.55–0.86, P = 0.048).ConclusionTTS pathophysiology comprises transient impairments in LA reservoir and conduit functions and enhanced bi-atrial active booster pump functions. Atrial CMR-FT may evolve as a superior marker of adverse events over and above established parameters such as LVEF and atrial volume.
Does heart failure-specific health status identify patients with bothersome symptoms, depression, anxiety, and/or poorer spiritual well-being?
Authors: Flint Kelsey M , Fairclough Diane L , Spertus John A , Bekelman David B 
Published: December 2018

Abstract

Aims
Patients with heart failure often have under-recognized symptoms, depression, anxiety, and poorer spiritual well-being (‘QoL domains’). Ideally all patients should have heart failure-specific health status and quality of life (QoL) domains routinely evaluated; however, lack of time and resources are limiting in most clinical settings. Therefore, we aimed to evaluate whether heart failure-specific health status was associated with QoL domains and to identify a score warranting further evaluation of QoL domain deficits.

Methods and results
Participants (N = 314) enrolled in the Collaborative Care to Alleviate Symptoms and Adjust to Illness trial completed measures of heart failure-specific health status [Kansas City Cardiomyopathy Questionnaire, KCCQ (score 0–100, 0 = worst health status)], additional symptoms (Memorial Symptom Assessment Scale), depression (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorder-7), and spiritual well-being (Facit-Sp) at baseline. Mean ± standard deviation (SD) KCCQ score was 46.9 ± 19.3, mean age was 65.5 ± 11.4, and 79% were male. Prevalence of QoL domain deficits ranged from 11% (nausea) to 47% (depression). Sensitivity/specificity of KCCQ for each QoL domain ranged from 20–40%/80–96% for KCCQ ≤ 25, 61–84%/48–62% for KCCQ ≤ 50, 84–97%/26–40% for KCCQ ≤ 60, and 96–100%/8–13% for KCCQ ≤ 75. Patients with KCCQ ≤ 60 had mean ± SD 4.5 ± 2.5 QoL domain deficits (maximum 12), vs. 1.6 ± 1.6 for KCCQ > 60 (P < 0.001). Similar results were seen for KCCQ ≤25 (6.6 ± 2.4 vs. 3.3 ± 2.4), KCCQ ≤ 50 (4.8 ± 2.6 vs. 2.5 ± 2) and KCCQ ≤ 75 (4.0 ± 2.6 vs. 1.0 ± 1.2) (all P < 00001).

Conclusion
KCCQ ≤ 60 had good sensitivity for each QoL domain deficit and for patients with at least one QoL domain deficit. Screening for QoL domain deficits should target patients with lower KCCQ scores based on a clinic’s KCCQ score distribution and clinical resources for addressing QoL domain deficits.
MAV-clic: management, analysis, and visualization of clinical data
Authors: Ahmed Zeeshan , Kim Minjung , Liang Bruce T 
Published: December 2018

AbstractObjectivesDevelop a multifunctional analytics platform for efficient management and analysis of healthcare data.Materials and MethodsManagement, Analysis, and Visualization of Clinical Data (MAV-clic) is a Health Insurance Portability and Accountability Act of 1996 (HIPAA)-compliant framework based on the Butterfly Model. MAV-clic extracts, cleanses, and encrypts data then restructures and aggregates data in a deidentified format. A graphical user interface allows query, analysis, and visualization of clinical data.ResultsMAV-clic manages healthcare data for over 800 000 subjects at UConn Health. Three analytic capabilities of MAV-clic include: creating cohorts based on specific criteria; performing measurement analysis of subjects with a specific diagnosis and medication; and calculating measure outcomes of subjects over time.DiscussionMAV-clic supports clinicians and healthcare analysts by efficiently stratifying subjects to understand specific scenarios and optimize decision making.ConclusionMAV-clic is founded on the scientific premise that to improve the quality and transition of healthcare, integrative platforms are necessary to analyze heterogeneous clinical, epidemiological, metabolomics, proteomics, and genomics data for precision medicine.