bluuebunny/crossref_metadata_2025_split huggingface dataset:
What are the research priorities for idiopathic intracranial hypertension? A priority setting partnership between patients and healthcare professionals
Authors: Mollan Susan , Hemmings Krystal , Herd Clare P , Denton Amanda , Williamson Shelley , Sinclair Alexandra J 
Published: March 2019

ObjectiveIdiopathic intracranial hypertension (IIH) is under-researched and the aim was to determine the top 10 research priorities for this disease.DesignA modified nominal group technique was used to engage participants who had experience of IIH.SettingThis James Lind Alliance Priority Setting Partnership was commissioned by IIH UK, a charity.ParticipantsPeople with IIH, carers, family and friends, and healthcare professionals participated in two rounds of surveys to identify unique research questions unanswered by current evidence. The most popular 26 uncertainties were presented to stakeholders who then agreed the top 10 topics.ResultsThe top 10 research priorities for IIH included aetiology of IIH, the pathological mechanisms of headache in IIH, new treatments in IIH, the difference between acute and gradual visual loss, the best ways to monitor visual function, biomarkers of the disease, hormonal causes of IIH, drug therapies for the treatment of headache, weight loss and its role in IIH and finally, the best intervention to treat IIH and when should surgery be performed.ConclusionsThis priority setting encouraged people with direct experience of IIH to collectively identify critical gaps in the existing evidence. The overarching research aspiration was to understand the aetiology and management of IIH.
Effectiveness of complex multiple-risk lifestyle interventions in reducing symptoms of depression: a study protocol for a systematic review and meta-analysis of randomised controlled trials
Authors: Gómez-Gómez Irene , Motrico Emma , Moreno-Peral Patricia , Rigabert Alina , Conejo-Cerón Sonia , Ortega-Calvo Manuel , Recio José-Ignacio , Bellón Juan A 
Published: March 2019

IntroductionMany studies have explored the impact of lifestyle interventions on depression. However, little is known about the effectiveness of complex multiple-risk lifestyle interventions in reducing symptoms of depression. Our objective is to assess the effectiveness of complex multiple-risk lifestyle interventions in reducing depressive symptoms in the adult population by the acquisition of at least two healthy habits—healthy diet, physical activity and/or smoking cessation. For such purpose, a systematic review and meta-analysis of randomised controlled trials will be conducted.Method and analysisMEDLINE (through Ovid and PubMed), Scopus, Cochrane Central Register of Controlled Trials, Web of Science, PsycINFO, OpenGrey Register (System for Information on Grey Literature in Europe) and the International Clinical Trials Registry Platform will be searched for relevant articles. Additionally, a supplementary manual search will be performed using lists of references, references to expert authors and other systematic reviews and/or meta-analyses. Study selection, data extraction (target habits, country, target populations, conditions and statistical data to name a few) and assessment of the risk of bias will be performed separately by two independent researchers. The primary outcome measure will be the reduction of depression symptoms, as measured by validated instruments. We will calculate pooled standardised mean differences and 95% CIs using random-effect models. Heterogeneity, sensitivity and publication bias will be assessed, and sub-group analysis will be performed. Heterogeneity will be explored by random-effects meta-regression analysis.Ethics and disseminationEthical approval is not required for this study. The results of this systematic review and meta-analysis will be presented in relevant conferences and published in a peer-review journal. The findings of this study could have important clinical and scientific implications for the improvement of symptoms of depression.PROSPERO registration numberCRD42018100253; Pre-results.
Ultrasound imaging versus palpation method for diagnostic lumbar puncture in neonates and infants: a systematic review and meta-analysis
Authors: Olowoyeye Abiola , Fadahunsi Opeyemi , Okudo Jerome , Opaneye Oluwakare , Okwundu Charles 
Published: March 2019

ImportanceLumbar puncture (LP) failure rates vary and can be as high as 65%. Ultrasound guidance could increase the success of performing LP.ObjectiveTo summarise the evidence on the use of ultrasound guidance versus palpation method for LP.Data sourcesWe searched computerised databases and published indexes, registries and references identified from bibliographies of pertinent articles without any language restrictions to find studies that compared ultrasound guidance to palpation method for performing an LP.Study selectionStudies were included if they were randomised or quasirandomised trials in neonates and infants that compared ultrasound guidance with palpation method for performing an LP.Data extraction and synthesisStandardised data collection tool was used for data extraction, and two reviewers independently assessed the quality of the studiesMain outcome(s) and measure(s)The primary outcome was the risk of LP failure, while the risk of traumatic tap, needle redirections/reinsertions and procedure durations were secondary outcomesResultsData from four studies and 308 participants is included in the analysis. Ultrasound imaging reduced the risk of LP failure, risk ratio of 0.58 (95% CI 0.15 to 2.28), but it was not statistically significant (p=0.44). Ultrasound imaging significantly reduced the risk of a traumatic tap risk ratio of 0.33 (95% CI 0.13 to 0.82) and p=0.02. The included studies had low to moderate quality; the studies differed based on mean age and with variability on outcome definition.Conclusions and relevanceThis meta-analysis suggests that ultrasound imaging has no effect in increasing lumbar success but is beneficial in reducing the risk of traumatic taps in neonates and infants.Trial registration numberCRD42017055800.
Age independent survival benefit for patients with hepatocellular carcinoma (HCC) without metastases at diagnosis: a population-based study
Authors: De Toni Enrico N , Schlesinger-Raab Anne , Fuchs Martin , Schepp Wolfgang , Ehmer Ursula , Geisler Fabian , Ricke Jens , Paprottka Philipp , Friess Helmut , Werner Jens , Gerbes Alexander L , Mayerle Julia , Engel Jutta 
Published: March 2019

ObjectiveHepatocellular carcinoma (HCC) is a major cause of death worldwide and its incidence is expected to increase globally. Aim of this study was to assess whether the implementation of screening policies and the improvement of treatment options translated into a real-world survival benefit in HCC patients.Design4078 patients diagnosed with HCC between 1998 and 2016 from the Munich Cancer Registry were analysed. Tumour characteristics and outcome were analysed by time period and according to age and presence of metastases at diagnosis. Overall survival (OS) was analysed using Kaplan-Meier method and relative survival (RS) was computed for cancer-specific survival. Cox proportional hazard models were conducted to control for prognostic variables.ResultsWhile incidence of HCC remained substantially stable, tumours were diagnosed at increasingly earlier stages, although the median age at diagnosis increased. The 3 years RS in HCC improved from 19.8% in 1998–2002, 22.4% in 2003–2007, 30.6% in 2008–2012 up to 31.0% in 2013–2016. Median OS increased from 6 months in 1998–2002 to 12 months in 2008–2016. However, analysis according to the metastatic status showed that survival improved only in patients without metastases at diagnosis whereas the prognosis of patients with metastatic disease remained unchanged.ConclusionThese real-world data show that, in contrast to the current assumptions, the incidence of HCC did not increase in a representative German region. Earlier diagnosis, likely related to the implementation of screening programmes, translated into an increasing employment of effective therapeutic options and a clear survival benefit in patients without metastases at diagnosis, irrespective of age.
FIGURAÇÕES DO FEMININO NA POESIA ERÓTICA DE ALBERTO PIMENTA
Authors: Cardoso Inês 
Published: March 2019

Resumo: Pensar a erotização do corpo feminino na poesia portuguesa da segunda metade do século XX exige a revisitação de uma nova imagem da mulher, que à altura se apresentou espelhada numa visão libertária da sexualidade feminina e na ação reivindicativa da luta feminista. Partindo das três primeiras obras de Alberto Pimenta, cuja publicação coincidiu, em território nacional, com o período de vigência do Estado Novo, este artigo procura compreender o modo como as figuras femininas emergem num fazer poético onde o erotismo sempre caminhou a par de uma denúncia profundamente cáustica e irreverente.Palavras-chave: Alberto Pimenta, poesia portuguesa, poesia erótica, figurações do feminino, erotismo. Abstract: In order to contemplate the eroticisation of the female body in Portuguese poetry from the second half of the twentieth century, it is necessary to re-visit the new image of woman, which at that time was reflected in a libertarian vision of female sexuality and in the increasing activism of the feminist struggle. Focusing on the first three works of Alberto Pimenta, whose publication coincided, in the Portuguese context, with the “Estado Novo” dictatorship, this article seeks to understand the way in which female figures emerge from a poetic practice where eroticism always appeared in tandem with a deeply caustic and irreverent social criticism.Keywords: Alberto Pimenta, Portuguese poetry, erotic poetry, representations of the feminine, eroticism.
A "MÍMESIS" FANTÁSTICA NA OBRA SATÍRICA DE NICOLAU TOLENTINO E O "VT PHOTOGRAPHIA POESIS"
Authors: Pinto Rodrigo Gomes de Oliveira 
Published: March 2019

Na obra satírica do poeta lusitano Nicolau Tolentino de Almeida (1740-1811), os sonetos “Aos toucados altos” e “O colchão dentro do toucado” podem ser lidos como exemplares de poesia cômico-fantástica composta no domínio da prescrição da arte mimética. Assim, feitos da nitidez, da clareza e da vivacidade efetuadas pela figura retórica da hipotipose, os versos desses sonetos fazem parecer empírico o fingido, a fim de escarnecer costumes vistos como desmedidos e fazer iteração moralizante do comedimento. Manuel Pinheiro Chagas (1842-1895), leitor oitocentista de Nicolau Tolentino, afirma que o uso do verbo “photographar” não é capaz de dizer a vividez descritiva dos versos desses sonetos, de modo que não pareça conveniente ler a obra poética do satirista de acordo com parâmetros que postulem uma espécie de ut photographia poesis.
"I FUTURISTI" E OS FUTURISTAS DE "ORPHEU" (SANTA-RITA PINTOR E ALMADA NEGREIROS)
Authors: Pereiro Carlos Paulo Martínez 
Published: March 2019

I futuristi e os futuristas de Orpheu(Santa-Rita Pintor e Almada Negreiros) RESUMO: Este artigo parte da (re)conhecida ideia almadiana de a revista Orpheu ter representado o “encontro português das letras e da pintura” – isto é, o entrecruzado affaire verbale et visuelle que a delimita de maneira basilar e a que a publicação obedece como princípio reitor. Trata-se, por um lado, de analisar criticamente o obstinado rigor interartístico derivado da dupla obediência criativa do (para)futurista e poliapto criador Almada Negreiros e, por outro lado, de dissertar, in absentia, dos quatro hors-texte duplos do (pro)futurista e mitificador Santa-Rita Pintor, reproduzidos no segundo número da efémera e marcante publicação literária portuguesa.Destarte, inter alia, além de dissertarmos sobre a questão dos futuristi primários no que diz respeito desses dois ‘futuristas derivados’, ponderando a pensée contraditória e o pensum amalgamático que alicerzam a sua elaboração, procuramos ler as transitivas e concretas criações em palavras e/ou imagens de Almada e Santa-Rita – isto é, distantes de qualquer ‘imaculada concepção’, pretendemos decifrá-las, decodificá-las e/ou interpretá-las dentro dos referentes programáticos e efetivos de um futurismo tou court. I futuristi and the Futurists of Orpheu(Santa-Rita Pintor and Almada Negreiros)ABSTRACT: This article takes as its starting point the (well-) known Almadian idea that the magazine Orpheu represented the “Portuguese meeting point for literature and painting” – that is, the crossroads for affaire verbale et visuelle which defines it fundamentally and which the publication takes as its guiding principle. It is our intention, on the one hand, to review the obstinate inter-artistic rigor which is derived from the dual creative obedience to the (para) futuristic and multi-faceted creator Almada Negreiros and, on the other hand, to discuss, in absentia, of the four dual hors-texte by the (pro) futuristic myth-maker Santa-Rita Pintor, reproduced in the second number of this ephemeral and remarkable Portuguese literary publication.Thus, inter alia, in addition to discussing the question of the first futuristi with respect to these two 'derived futurists', considering the contradictory pensée and the amalgamated pensum that lay the foundation for their preparation, we endeavour to read the transitive and concrete creations in the words and / or pictures of Almada and Santa-Rita – that is, far from any 'immaculate conception', we aim to decipher them, decode them and / or interpret them within the programmatic and effective respect of a tou court futurism.
CASIMIRO DE BRITO: O “RIGOR E A CLARIDADE ENIGMÁTICA DO PENSAMENTO”
Authors: Barros Teixeira Claudio Alexandre 
Published: March 2019

RESUMO O artigo aborda o trabalho desenvolvido por Casimiro de Brito para a divulgação da poesia japonesa em Portugal por meio da tradução, da reflexão crítica e do próprio exercício poético na forma do haicai, adaptada às possibilidades da língua portuguesa. Entre as questões teóricas apresentadas no presente texto está a discussão sobre a atividade tradutória compreendida como recepção criativa, que estabelece uma tensão entre a língua de partida e a de chegada, entre diferentes repertórios culturais e tempos históricos, transformando o texto original em um novo artefato semântico.
Fraturas, carste e cavernas nos calcários Jandaíra em Felipe Guerra, Rio Grande do Norte
Authors: Gomes Iris Pereira , Veríssimo César Ulisses Vieira , Bezerra Francisco Hilário Rego , Santos Jefferson Lima dos , Câmara José Ronaldo De Freitas 
Published: March 2019

Condicionantes estruturais e geológicos foram estudados no lajedo do Arapuá em Felipe Guerra, oeste da Bacia Potiguar, com objetivo de avaliar sua influência no controle e na evolução de feições cársticas em carbonatos cretáceos da Formação Jandaíra. O arranjo estrutural das descontinuidades mostra a existência de quatro famílias de fraturas com direções preferenciais: NW-SE, NE-SW, N-S e E-W, as quais coincidem tanto com os principais sistemas de falhas da Bacia Potiguar como com a direção de desenvolvimento de cavernas na área de estudo. A caverna de Arapuá, principal cavidade da área, foi mapeada em escala de detalhe e realizado o levantamento estrutural das descontinuidades presentes no seu interior. As galerias principais que delimitam o contorno da caverna, as fendas e os alinhamentos de estalactites no teto, obedecem ao controle estrutural similar observado na superfície do lajedo. A simulação estocástica booleana aplicada às descontinuidades da área estudada permitiu a geração de gráficos tridimensionais que forneceram uma visão tridimensional (3D) da intensidade e da orientação espacial das estruturas em três profundidades distintas, reforçando a tendência das direções de fraturamento reconhecidas em superfície, com grande redução da ocorrência e penetratividade das direções E-W e N-S com a profundidade. O arranjo estrutural local coincide com o regional observado na Bacia Potiguar, configurado por um sistema de falhas extensionais que limitam altos e baixos estruturais orientados segundo NE-SW e NW-SE, herdados da fragmentação do supercontinente Gondwana e da abertura do Atlântico Sul. Pequenas falhas NE-SW com movimentação direcional dextral sugerem associação com estruturas reativadas em regime transcorrente. Entre as diferentes fácies reconhecidas nas seções da caverna de Arapuá, os mudstones e os carbonatos cristalinos correspondem
Acute Effects of Heat‐Not‐Burn, Electronic Vaping, and Traditional Tobacco Combustion Cigarettes: The Sapienza University of Rome‐Vascular Assessment of Proatherosclerotic Effects of Smoking (SUR‐VAPES) 2 Randomized Trial
Authors: Biondi‐Zoccai Giuseppe , Sciarretta Sebastiano , Bullen Christopher , Nocella Cristina , Violi Francesco , Loffredo Lorenzo , Pignatelli Pasquale , Perri Ludovica , Peruzzi Mariangela , Marullo Antonino G.M. , De Falco Elena , Chimenti Isotta , Cammisotto Vittoria , Valenti Valentina , Coluzzi Flaminia , Cavarretta Elena , Carrizzo Albino , Prati Francesco , Carnevale Roberto , Frati Giacomo 
Published: March 2019

Background

Little clinical research on new‐generation heat‐not‐burn cigarettes (
HNBC
) in comparison with electronic vaping cigarettes (
EVC
) and traditional tobacco combustion cigarettes (
TC
) has been reported. We aimed to appraise the acute effects of single use of
HNBC
,
EVC,
and
TC
in healthy smokers.

Methods and Results

This was an independent, cross‐over, randomized trial in 20
TC
smokers, with allocation to different cycles of
HNBC
,
EVC
, and
TC
. All participants used all types of products, with an intercycle washout of 1 week. End points were oxidative stress, antioxidant reserve, platelet activation, flow‐mediated dilation, blood pressure, and satisfaction scores. Single use of any product led to an adverse impact on oxidative stress, antioxidant reserve, platelet function, flow‐mediated dilation, and blood pressure.
HNBC
had less impact than
EVC
and
TC
on soluble Nox2‐derived peptide (respectively,
P
=0.004 and 0.001), 8‐iso‐prostaglandin F2α‐
III
(
P
=0.004 and <0.001), and vitamin E (
P
=0.018 and 0.044).
HNBC
and
EVC
were equally less impactful than
TCs
on flow‐mediated dilation (
P
=0.872 for
HNBC
versus
EVC
), H
2
O
2
(
P
=0.522), H
2
O
2
breakdown activity (
P
=0.091), soluble
CD
40 ligand (
P
=0.849), and soluble P‐selectin (
P
=0.821). The effect of
HNBC
and, to a lesser extent
EVC
, on blood pressure was less evident than that of
TC
, whereas
HNBC
appeared more satisfying than
EVC
(all
P
<0.05).

Conclusions

Acute effects of
HNBC
,
EVC,
and
TC
are different on several oxidative stress, antioxidant reserve, platelet function, cardiovascular, and satisfaction dimensions, with
TCs
showing the most detrimental changes in clinically relevant features.

Clinical Trial Registration

URL
:
http://www.clinicaltrials.gov
. Unique identifier:
NCT
03301129.
Contemporary Outcomes in Low‐Gradient Aortic Stenosis Patients Who Underwent Dobutamine Stress Echocardiography
Authors: Sato Kimi , Sankaramangalam Kesavan , Kandregula Krishna , Bullen Jennifer A. , Kapadia Samir R. , Krishnaswamy Amar , Mick Stephanie , Rodriguez L. Leonardo , Grimm Richard A. , Menon Venu , Desai Milind Y. , Svensson Lars G. , Griffin Brian P. , Popović Zoran B. 
Published: March 2019

Background

Detection of flow reserve (
FR
) by dobutamine stress echocardiography is used for risk stratification in low‐gradient aortic stenosis (
AS
). Prognostic significance of dobutamine stress echocardiography in the transcatheter aortic valve replacement era is unclear. We aimed to assess the current relevance of
FR
.

Methods and Results

We studied 235 patients with low‐gradient severe
AS
(rest aortic valve area ≤1.0 cm
2
or indexed aortic valve area ≤0.60 cm
2
/m
2
; mean aortic valve gradient <40 mm Hg) and left ventricular ejection fraction <50%) with dobutamine stress echocardiography done September 2010 through July 2016.
FR
was defined by ≥20% stroke volume increase. We diagnosed “true‐severe
AS
” if peak aortic valve velocity ≥4 m/s occurred with aortic valve area ≤1.0 cm
2
(or indexed aortic valve area ≤0.6 cm
2
/m
2
). At a median time of 51 days, 128 patients underwent aortic valve replacement,either surgical aortic valve replacement (n=42) or transcatheter aortic valve replacement (n=86).
FR
was observed in 138 patients, while 86 patients had true‐severe
AS
. During median follow‐up of 2.3 years, 138 patients died. In a multivariable model, aortic valve replacement (hazard ratio 0.41, 95%
CI
: 0.29–0.58,
P
<0.001) and lower Society of Thoracic Surgeons score (hazard ratio 1.06, 95%
CI
: 1.04–1.09,
P
<0.001) were associated with better survival, while
FR
was not predictive. aortic valve replacement was associated with survival regardless of the presence or absence of
FR
or
AS
severity stratification.

Conclusions

In low‐gradient
AS
with reduced ejection fraction,
FR
or
AS
severity stratification by dobutamine stress echocardiography was not associated with survival. Aortic valve replacement was associated with better survival in low‐gradient
AS
independent of
FR
.
Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study
Authors: Etyang Anthony O. , Kapesa Sailoki , Odipo Emily , Bauni Evasius , Kyobutungi Catherine , Abdalla Marwah , Muntner Paul , Musani Solomon K. , Macharia Alex , Williams Thomas N. , Cruickshank J. Kennedy , Smeeth Liam , Scott J. Anthony G. 
Published: March 2019

Background

Malaria exposure in childhood may contribute to high blood pressure (
BP
) in adults. We used sickle cell trait (
SCT
) and α
+
thalassemia, genetic variants conferring partial protection against malaria, as tools to test this hypothesis.

Methods and Results

Study sites were Kilifi, Kenya, which has malaria transmission, and Nairobi, Kenya, and Jackson, Mississippi, where there is no malaria transmission. The primary outcome was 24‐hour systolic BP. Prevalent hypertension, diagnosed using European Society of Hypertension thresholds was a secondary outcome. We performed regression analyses adjusting for age, sex, and estimated glomerular filtration rate. We studied 1127 participants in Kilifi, 516 in Nairobi, and 651 in Jackson.
SCT
frequency was 21% in Kilifi, 16% in Nairobi, and 9% in Jackson.
SCT
was associated with −2.4 (95%
CI
, −4.7 to −0.2) mm Hg lower 24‐hour systolic BP in Kilifi but had no effect in Nairobi/Jackson. The effect of
SCT
in Kilifi was limited to 30‐ to 59‐year‐old participants, among whom it was associated with −6.1 mm Hg (
CI
, −10.5 to −1.8) lower 24‐hour systolic BP. In pooled analysis allowing interaction by site, the effect of
SCT
on 24‐hour systolic BP in Kilifi was −3.5 mm Hg (
CI
, −6.9 to −0.1), increasing to −5.2 mm Hg (
CI
, −9.5 to −0.9) when replacing estimated glomerular filtration rate with urine albumin to creatinine ratio as a covariate. In Kilifi, the prevalence ratio for hypertension was 0.86 (
CI
, 0.76–0.98) for
SCT
and 0.89 (
CI
, 0.80–0.99) for α
+
thalassemia.

Conclusions

Lifelong malaria protection is associated with lower
BP
in Kilifi. Confirmation of this finding at other sites and elucidating the mechanisms involved may yield new preventive and therapeutic targets.