bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suspected Hereditary Cancer Syndromes in Young Patients: Heterogeneous Clinical and Genetic Presentation of Colorectal Cancers
Authors: Maletzki Claudia , Hühns Maja , Bauer Ingrid , Prall Friedrich , Junghanss Christian , Henze Larissa 
Published: January 2019

Abstract

Colorectal cancer (CRC) is rare in young patients without a confirmed family history of cancer. Reports of an increased prevalence of POLD1/POLE mutations in young patients with colorectal cancer have raised awareness and support routine genetic testing for patients with early-onset tumors. In cases of CRC without proven MMR-germline mutation, molecular analyses are warranted to confirm or rule out other familial CRC syndromes. This article describes the cases of two young male patients, who presented with locally advanced and metastatic CRC, and reports the results of the germline mutational analyses done for both patients. These cases demonstrate the importance of special care and molecular diagnostic procedures for young patients with CRC.

Key Points
Patients with colorectal cancer who are younger than 50 years at initial diagnosis (early onset) should routinely undergo genetic testing. Early- and very-early-onset patients (younger than 40 years) with absence of microsatellite instability should be considered for tumor mutation burden testing and/or DNA polymerase proofreading mutation. The mutational signature of HSP110 within mismatch repair deficiency-related tumors may help to identify patients likely to benefit from 5-fluorouracil-based chemotherapy. Intensified, maintained, and specific surveillance may help to reduce secondary tumor progression.
Maternal and neonatal outcomes in pregnancies complicated by maternal obesity
Authors: Menon Sudha , K. Sivaprasad 
Published: January 2019

Background: Maternal obesity imparts elevated maternal and neo natal adverse outcomes. Aim of the study was to evaluate and analyse the maternal and neonatal outcomes in obese mothers.Methods: This was a prospective case control study in a tertiary care high risk referral center. Antenatal women with first trimester Body mass index (BMI) of more than 30 Kg/m2 constituted the cases and those antenatal women with BMI <25 Kg/m2 formed the controls.Results: Mean age was slightly more (28.6±4.3 years vs 26.3±3.6 years: P<0.0001) in the obese group. Obese women were significantly more likely to have of gestational diabetes (OR 5.2, 95% CI 3.2-8.7 P<0.00001), gestational hypertension (Or 3.5, 95% CI 2.1-5.9 P<0.0001) , induction of labour (OR 2.5, 95% CI 1.8-3.6 P<0.0001), failed induction of labour (OR 2.4, 95% CI 1.3-4.2 P=0.003), Preeclampsia (OR 2.8, 95% CI 1.6-4.9 P=0.0002), Caesarian section (Or 4.0, 95% CI 2.9-5.9 P<0.0001) and Postpartum hemorrhage (OR 4.0,95% CI 1.1-14.3 P=0.034), prolonged hospital stay (OR 12.8, 95% CI 7.7-21.1 P<0.0001) and adverse neonatal outcomes such as low(<7) Apgar (OR 3.2, 95% CI 1.1-10.0 P=0.03), Large for gestational age babies (OR 3.1, 95% Cl 2.1-4.5 P<0.0001) and transfer to new born nursery (OR 3.4, 95% CI 2.3 -5.2 P<0.0001).Conclusions: Maternal obesity in pregnancy is high risk and has many adverse maternal and neonatal outcomes warranting specialized antenatal, intranatal and post-natal care.
Prevalence and predictors of metabolic syndrome with comparison of myoinositol and metformin in PCOS women
Authors: Modak Rupali , Biswas Dilip Kumar , Pal Amitava , Mandal Tapan Kumar 
Published: January 2019

Background: The objective is to determine the prevalence of metabolic syndrome (MBS) and the effects of insulin sensitizers to improve the clinical and hormonal milieu for better reproductive outcome in PCOS women.Methods: This prospective cross-sectional study was conducted on 50 PCOS women and 50 age matched control to determine the prevalence of the MBS in two tertiary hospitals over one year. Diagnosis of PCOS was based on at least two of ESHRE/ASRM criteria and diagnosis of MBS was based on at least three of NCEPATPIII criteria. Patients already diagnosed as PCOS were treated with insulin sensitizers myoionositol and metformin which were compared.Results: The study revealed that the prevalence of MBS was 40 % (20/50) nearly 4-fold higher than that of control groups. Among PCOS women, the most prevalent MBS factors were high BMI (52%) and low serum HDL-C (42%). The least prevalent factor was high fasting serum glucose level (16%). The resumption of spontaneous regular menstrual cycle and pregnancy rate in infertile groups of PCOS patients with myoionositol and metformin were 61% vs. 26% and 50% vs.91% respectively. The myoionositol group did not require any extra ovulating agents for pregnancy, while 7 out of 11 patients in metfromin group needed clomiphen citrate for ovulation induction to achieve pregnancy. With myoinositol there is significant reduction of weight, BMI, LH/FSH ratio and fasting insulin level; whereas metformin shows decrement of weight and BMI only.Conclusions: The prevalence of MBS in PCOS is nearly 4 times in present study and there is significant improvement of symptom profile, weight, BMI and change of hormonal pattern in myoinositol group.
Risk factors and outcome of placenta previa: accrete in a tertiary health care center of Punjab, India
Authors: Pal Davinder , Bhagat Nisha , Arora Ritu 
Published: January 2019

Background: The aim of this study was to identify and evaluate risk factors associated with placenta accrete (PA) and its clinical outcome.Methods: A descriptive, case control study was conducted in department of obstetrics and gynecology, GMC Amritsar in which authors retrospectively reviewed data of 180 patients of placenta previa (PP) over 5 years, categorized as PA (cases; n=23) or no PA (control; n=157). Furthermore, these groups were compared as to maternal demographics, intrapartum and postpartum complications and neonatal outcomes. Stepwise logistic regression analysis was done to evaluate the extent to which exposure variable contributed to the incidence of PA including advanced maternal age (AMA), parity, location of placenta and previous caesarian section (CS). Primary aim was to identify and quantify the various risk factors of PA and secondary aim measured incidences of PP, PA and fetomaternal outcome.Results: The cumulative incidence of PA over 5 years was 2.98 per 1000 deliveries. Accrete rate increased with number of CSs at 4.76% in patients with no previous CS versus 45.94% in ≥1 CS (p < 0.003). Anterior PP (AOR 10.128 CI 2.406 -42.632; p <0.001) and number of previous CSs (AOR 36.405, 95% CI 2.743 -483.24, p =0.006) were significant risk factors for PA. AMA (OR >30 years: 4.326 95% CI 0.724 -25.856; p =0.108), parity (AOR 1 vs 0: 2.526 95% CI 0.242-26.41; p=0.439), prior uterine curettage (AOR ≥1 vs 0: 11.143 95% CI 0.522-9.726; p=0.278) although had association with PA but was not statistical significant. Caesarian hysterectomy was done in 95.65% patients of PA while only 1 patient of PP required hysterectomy (p<0.001). Neonatal outcome was similar in both groups.Conclusions: Prior caesarian and anterior PP emerged out as significant predictors of PA. Other risk factors like AMA, multiparous, history of prior uterine curettage, central PP have incremental risk of having PA and such patients should be managed diligently to lower feto-maternal morbidities and mortalities.
A unique solution to improve an amblyopic child’s adherence to patching
Authors: Alharkan Dora H. 
Published: January 2019

Amblyopia should be treated in early ages to have better outcomes. Stimulation of suppressed eye and depriving light stimulus to the good eye is the main principal of the amblyopia treatment. Adherence to the patching for the treatment of amblyopia in children remains challenging. This could be due to poor cooperation of child or ill-fitting patch. Younger children can be motivated to mimic cartoon figures to improve their adherence to patching. Amblyopia treatment is a team work of parents and optometrist who not only select the mode of management but improve the acceptance of child for patching. We present a child with mild anisometropia and hypermetropia-induced esotropia and amblyopia who was non-compliant to patching. An innovative idea by the parents using a Ninja Turtle patch on the prescribed spectacle was very well accepted by the child and both esotropia and amblyopia improved within four months of the patching treatment. The vision in the affected eye improved from 20/200 to 20/20 with refractive error correction and patching. We share this low-cost child-friendly patching technique that parents invented that can be used to improve adherence to patching by young children during amblyopia therapy. This parent’s innovation enabled to improve adherence and thus address amblyopia in patched eye and regain vision.
In vitro selection for Fusarium oxysporum f. sp. conglutinans resistance in brassica vegetables
Authors: Abeyawardana Oushadee A. J. , Koudela Martin 
Published: January 2019

<p class="abstract"><strong>Background:</strong> Fusarium wilt is an issue of concern in economically and nutritionally important Brassica vegetable cultivation. Thus, it deserves measures against the adverse production impact caused by Fusarium wilt.</p><p class="abstract"><strong>Methods:</strong> In this study, development of resistance to <em>F. oxysporum</em> f. sp. <em>conglutinans</em> in six white head cabbage cultivars, by in vitro chemical mutagenesis and selection, through direct and indirect organogenesis was examined. 6 day and 10 day old hypocotyl, shoot tip and calli, from 6 day old hypocotyl explants, were subjected to chemical mutagenesis treatment (DMSO (4% v/v) + EMS (0.3% v/v) for two hours at 28±2°C) were incubated in MS shoot induction medium (MS+ NAA (0.2 mg/l), BAP (3 mg/l), GA3 (0.01 mg/L) and AgNO3 (0.5 mg/l)). Shoots developed from hypocotyl and shoot tip explants (in the MS shoot induction medium and then in MS + NAA (0.2 mg/l), BAP (3 mg/l), GA3 (0.01 mg/l) for shoot development) and calli following mutagenesis treatment were screened for Fusarium resistance subjecting to 15% and 20% <em>Fusarium</em> culture filtrate for 30 and 60 day selection periods for each strength respectively. </p><p class="abstract"><strong>Results:</strong> Developed plantlets from all six cultivars tested, showed resistance to<em> </em>Fusarium culture filtrate in the in vitro conditions with different survival frequencies ranging between 12.5% to 84.0% from hypocotyl and 0.0% to 86.7% from shoot tip explants among cultivars indicating development of resistance to <em>Fusarium</em> by in vitro chemical mutagenesis.</p><p class="abstract"><strong>Conclusions:</strong> Direct organogenesis, and 10 day old hypocotyl and 6 day old shoot tips are potential explants for successful application of in vitro chemical mutagenesis for Fusarrium resistance development in in cabbage.</p><p class="abstract"> </p>
Modifications of pulse therapy in pemphigus: a retrospective study of 72 patients
Authors: Bhuptani Neela V. , Chauhan Khushbu P. , Jadwani Monal M. , Raja Pooja 
Published: January 2019

<p class="abstract"><strong>Background:</strong> Pulse therapy defines as the administration of supra-pharmacologic doses of drugs in an intermittent manner to enhance the therapeutic effects and reduce the side effects. Dexamethasone-Cyclophosphamide pulse (DCP) therapy is known since 1986 but there are certain limitations due to side effects of cyclophosphamide.</p><p class="abstract"><strong>Methods:</strong> A retrospective study was carried out where 72 patients of pemphigus were treated with modified pulse therapy like DCP, DAP, DMP from 2006-2016. Modifications were made in DCP therapy protocol and substitution of cyclophosphamide with either azathioprine or methotrexate in few patients.<strong></strong></p><p class="abstract"><strong>Results:</strong> Male to female ratio observed was 1:0.7. Majority of them belonged to age group of 31-40 years (41.66%) followed by 41-50 years (33.3%). Maximum number of patients had pemphigus vulgaris (86.1%) followed by pemphigus foliaceous (12.5%) and IgA pemphigus (1.38%). Good response was observed in patients who took pulse therapy regularly.</p><p class="abstract"><strong>Conclusions:</strong> Modifications to the original DCP therapy protocol were found to be very effective, useful and it shortened the duration of phase I. Side effects were minimal and manageable.</p>
Implementasi Model Pembelajaran Active Learning Tipe Pengadilan Majelis Hakim Dalam Pembelajaran PJOK Materi Narkoba dan Pelecehan Seksual Pada Siswa Kelas VI SDN Tanggulangin I
Authors: Sunaryo Moch 
Published: January 2019

Penelitian ini bertujuan untuk Ingin mengetahui peningkatan prestasi belajar mata pelajaran PJOK setelah diterapkannya model pembelajaran active learning tipe pengadilan majelis hakim; dan mengetahui aktivitas belajar siswa kelas VI SDN Tanggulangin I Tahun Pelajaran 2015/2016 dengan diterapkannya model pembelajaran active learning tipe pengadilan majelis hakim. Penelitian ini menggunakan penelitian tindakan (action research) sebanyak 2 (dua) putaran. Setiap putaran terdiri dari empat tahap yaitu: rancangan, kegiatan dan pengamatan, refleksi, dan refisi. Sasaran penelitian ini adalah siswa kelas VI SDN Tanggulangin I tahun pelajaran 2015/2016. Data yang diperoleh berupa hasil tes formatif, dan lembar observasi kegiatan belajar mengajar. Dari hasil analis didapatkan bahwa prestasi belajar siswa mengalami peningkatan yang signifikan, dari siklus I sampai siklus II yaitu: siklus I (77,78%) dan siklus II (94,44%) dengan nilai rata-rata siklus I (79,56) dan siklus II (86,00). Pada akhirnya, model pembelajaran active learning tipe pengadilan majelis hakim dapat berpengaruh positif terhadap prestasi belajar siswa kelas VI SDN Tanggulangin I tahun pelajaran 2015/2016, serta model pembelajaran ini dapat digunakan sebagai salah satu alternatif pembelajaran mata pelajaran PJOK.
Permohonan Tanah Ulayat di Minangkabau Menjadi Tanah Hak Milik
Authors: Fatmi Siti Raga 
Published: January 2019

Communal land is an asset owned by customary law communities and jointly managed by members of customary law communities. Customary land in Minangkabau has been recognized in Indonesian law as mentioned in Article 3 of the Basic Agrarian Law Number 5 of 1960 (BAL) as long as it still exists and corresponding to the development. In fact, although a communal land in Minangkabau is administered collectively, the later development shows that such a communal land has been converted to the proprietary right by customary law communities due to the demand for legal recognition. BAL states that property rights are hereditary, strongest, and fulfilled rights owned by a person on a piece of land. Since there are no regulations governing the transfer of communal land to land ownership, the customary elders and regional apparatus make procedures for the transfer of communal land with certain conditions so that not everyone can submit an application for ownership of customary land into land owned.
Keywords: Customary Land, Proprietary Rights, Land Registration
STUDI PELACAKAN LULUSAN PROGRAM STUDI D3 TEKNIK SIPIL UNIVERSITAS NEGERI JAKARTA
Authors: Aprianto Andri , Maulana Arris , Nasution Nira 
Published: January 2019

This study aims to gain an overview and knowledge of the graduates of job profilesthat include the type of work that occupied areas, the waiting period to get a job, how to get a job, the amount of earned income, and employment status.
The research was conducted on D3 in Civil Engineering who graduated in odd semester of 2005/2006 until the second semester 2009/2010. Sampling was done by purposive sampling. The study population numbered 113 people. The research sample consists of 29 people. This research uses descriptive method with the waythe survey.
From the results of this study found that graduates who pursue work in the field of civilengineering work is now 82,76 %, while those working outside the field of civil engineering as much as 17,24 %. And for the first time job as much as 79,31 %worked in the field of civil engineering, while 20,69 % outside of civil engineering.Employment status of graduates on the job is now 55% is fixed and for the work of the first 72,41 % of the contract. Large salary in first job 48,28 % range between Rp 1.500.000 - Rp 2.500.000 per month, and the work that is now 27.58 % ranges between Rp 1.500.000 - Rp 2.500.000 and Rp 3.500.000 - Rp 4.500.000 per month. Graduation GPA of the most sought after companies ranging from 2,51-3,00. Organizational experience during campus 77.78 % were helped in the work world 48.27% obtained employment information from the internet. The waiting period to get a job at 86.21% is less than 3 months.
The conclusion from this study that the quality of the D3 in Civil Engineering work has begun to be recognized in the world. From the field of employment, graduates can work not only on earth but also can ketekniksipilan outside of civil engineering.Although most of the graduates are working in the world of civil engineering. And the expected results of this research can provide input to the future for D3 in Civil Engineering courses to be able to better tailor its curriculum current with the times to produce future graduates more competitive in the world of work.
MINAT MAHASISWA TERHADAP PROFESI GURU
Authors: Rouf Faruq Abdur , Neolaka Amos , Suyadi Dadang 
Published: January 2019

This study aims to reveal the level of student interest in technical education building of the FT UNJ the teaching profession, the study was conducted starting from March until July, 2016.
The study was conducted in Building Engineering Study Program, this research uses descriptive qualitative method, namely data collection techniques by spreading questionnaires and interviews as the reinforcement of the answers to the questionnaire.
The results of this study are students of Technical Education Building has a high interest in the teaching profession, they considered that the teaching profession is a noble job, and for that assessment increases the pleasure of students in teaching, and all it's the result that students PTB FT UNJ have high interest in the teaching profession
Analisa Kemampuan Mengajar Mahasiswa Jurusan Teknik Sipil Di Sekolah Menengah Kejuruan (SMK)
Authors: Murtinugraha R. Eka 
Published: January 2019

Tujuan penelitian ini untuk mengetahui bagaimana persepsi siswa terhadap keterampilan mengajar mahasiswa PKM Program Keahlian Teknik Bangunan. Tempat penelitian dilaksanakan di SMKN 1 Jakarta, SMKN 4 Jakarta, SMKN 26 Jakarta, SMKN 35 Jakarta, SMKN 58 Jakarta dan SMKN 1 Cibinong pada program keahlian teknik bangunan. Waktu penelitian dilaksanakan pada semester genap tahun 2015.
Pengumpulan data dan informasi dilakukan melalui penelitian kuantitatif deskriptif dengan menggunakan pendekatan survey. Pendekatan survey digunakan untuk mendapatkan data dari tempat tertentu yang alamiah (bukan buatan), tetapi peneliti melakukan perlakuan dalam pengumpulan data, misalnya dengan mengedarkan kuesioner, test, wawancara terstruktur dan sebagainya.
Hasil penelitian ini dapat disimpulkan bahwa pada keterampilan bertanya, mahasiswa PKM memiliki kemampuan yang cukup tinggi dibandingkan keterampilan lainnya. Untuk keterampilan memberikan penguatan, mahasiswa PKM masih kurang mampu dan mendapat nilai paling rendah. Untuk keterampilan lainnya, mahasiswa PKM mempunyai kemampuan yang cukup baik.
Faktor-Faktor yang Mempengaruhi Masa Studi Mahasiswa Pendidikan Teknik Bangunan Universitas Negeri Jakarta
Authors: Pratiwi Dita Ambar , Handoyo Santoso Sri , Murtinugraha R. Eka 
Published: January 2019

Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi masa studi mahasiswa program studi Pendidikan Teknik Bangunan di Jurusan Teknik Sipil, Fakultas Teknik, Universitas Negeri Jakarta. Penelitian berlangsung pada bulan Oktober sampai dengan November 2015.
Penelitian ini menggunakan metode penelitian deskriptif dengan menggunakan pendekatan survei. Teknik pengumpulan data dalam penelitian ini yaitu menggunakan angket/kuesioner. Kuesioner/angket yang digunakan dalam penelitian ini ialah angket tertutup dengan metode pilihan. Bentuk angket yang di susun menggunakan Skala Likert.
Hasil penelitian ini menunjukan bahwa faktor internal yang berasal dari faktor psikologis yakni bakat dan kecerdasan (62%) merupakan faktor internal yang paling mempengaruhi masa studi mahasiswa. Sedangkan pada faktor eksternal yang berasal dari faktor lingkungan kampus yakni teman-teman yang selalu membantu ketika mahasiswa kurang memahami materi perkuliahan (71%) merupakan faktor eksternal yang paling mempengaruhi masa studi mahasiswa.
Evaluasi Pelaksanaan Kurikulum 2013 pada SMK Negeri Program Keahlian Teknik Bangunan di Jakarta
Authors: Murtinugraha R. Eka 
Published: January 2019

Penelitian ini bertujuan untuk mengetahui seberapa besar keterlaksaan kurikulum 2013 terhadap masalah-masalah yang berkaitan dengan pelaksanaan 8 standar nasional pendidikan, di Sekolah Menengah Kejuruan Negeri Program Keahlian Teknik Bangunan di DKI Jakarta yang mencakup: (1) Standar penilaian pendidikan, (2) Standar sarana dan prasarana, (3) Standar pendidik, (4) Tenaga kependidikan, dan (5) Proses pembelajaran.
Penelitian dilakukan pada SMK Negeri di DKI Jakarta yang telah melaksanakan kurikulum 2013, pada tiga sekolah dengan Program Keahlian Teknik Bangunan yang meliputi SMK Negeri 26 Jakarta, SMK Negeri 1 Jakarta, dan SMK Negeri 35 Jakarta. Responden penelitian dalam masing-masing sekolah yaitu 1 kepala sekolah, 1 kepala program keahlian teknik bangunan, dan 6 guru program keahlian teknik bangunan, serta dari peserta didik. Penelitian ini menggunakan metode survei dengan pendekatan kuantitatif.
Hasil penelitian menunjukkan bahwa pelaksanaan kurikulum 2013 di SMK Negeri 26 Jakarta, SMK Negeri 1 Jakarta, dan SMK Negeri 35 Jakarta Program Keahlian Teknik Gambar Bangunan secara keseluruhan, meliputi: (1) Standar penilian pendidikan berada dalam kriteria sangat baik (83%); (2) Standar pendidik dan tenaga kependidikan dengan memfokuskan pada guru dan kepala sekolah memperoleh nilai rata-rata secara berturut dalam kategori sangat baik (83%) dan baik sebesar 76%; (3) Standar sarana dan prasarana berada dalam kriteria sangat baik dengan nilai sebesar 94% untuk rata-rata ketiga sekolah; (4) Proses kegiatan belajar mengajar di ketiga sekolah tergolong dalam kriteria sangat baik yaitu 80,13%.
Studi Analisis Terhadap Kemampuan Softskills Mahasiswa Fakultas Teknik UNJ
Authors: Iriani Tuti 
Published: January 2019

Penelitian ini bertujuan untuk memperoleh informasi tentang profil kemampuan soft skills yang dimiliki mahasiswa. Dalam penelitian ini, kemampuan soft skills mahasiswa diukur melalui kemampuan intrapersonal skills meliputi manajemen waktu, manajemen stress, manajemen perubahan, karakter personal, dan memiliki acun tujuan positif. Sedangkan interpersonal skill, meliputi kemampuan memotivasi, kemampuan memimpin/ teamwork, kemampuan presentasi, kemampuan komunikasi, kemampuan membuat relasi, dan kemampuan berbicara di depan umum. Hasil penelitian menunjukan bahwa Kemampuan Intrapersonal skills mahasiswa Fakultas Teknik UNJ dapat dikategorikan cukup baik untuk manajemen stress, manajemen perubahan, dan memiliki acuan tujuan positif. Namun demikian masih terdapat sebagian mahasiswa belum memiliki kesadaran diri terutama dalam manajemen waktu. Untuk kemampuan interpersonal skill mahasiswa Fakultas Teknik UNJ dapat dikategorikan cukup baik, seperti kemampuan memotivasi, kemampuan presentasi, kemampuan berkomunikasi, kemampuan membuat relasi. Sementara yang harus menjadi perhatian adalah kemampuan memimpin/ teamwork dan kemampuan berbicara di depan umum.