bluuebunny/crossref_metadata_2025_split huggingface dataset:
Martial arts increase oxytocin production
Authors: Rassovsky Yuri , Harwood Anna , Zagoory-Sharon Orna , Feldman Ruth 
Published: September 2019

AbstractNumerous studies have demonstrated that oxytocin (OT), a peptide hormone, plays an important role in regulating mammalian social behaviors, linking it to social affiliation in parent-infant attachment, romantic and filial relationships, and other prosocial behaviors, such as trust and cooperation. Not surprisingly, research efforts have been made to increase endogenous levels of OT. In the present study, we investigated whether traditional martial arts training, which integrates the natural benefits of physical exercise with dyadic prosocial interaction, would result in OT response. To this end, 68 beginner and advanced participants were recruited from several schools practicing Jujitsu (“soft art”), a form of traditional martial arts originating in Japan. Salivary OT levels were assessed at baseline, immediately following high-intensity training, and following a cool-down period. Analyses revealed a significant increase in OT immediately after a high-intensity training, returning to baseline levels following a cool-down period. Additionally, although no significant difference between beginner and advanced martial artists was found, a significantly higher increase in salivary OT followed ground grappling, as compared to “punch-kick” sparring, indicating an added benefit of close contact tactile interaction. These results suggest that the reportedly socially beneficial effects of traditional martial arts may be in part mediated by OT release and underscore the potentially therapeutic applications of these methods for disorders involving social dysfunction, such as autism, conduct problems, or schizophrenia.
miRNA-dependent regulation of STIM1 expression in breast cancer
Authors: Kulkarni Rashmi P. , Elmi Asha , Alcantara-Adap Ethel , Hubrack Satanay , Nader Nancy , Yu Fang , Dib Maya , Ramachandran Vimal , Najafi Shoushtari Hani , Machaca Khaled 
Published: September 2019

AbstractStore-operated Ca2+ entry (SOCE) has been shown to be important for breast cancer metastasis in xenograft mouse models. The ER Ca2+ sensor STIM1 and Orai plasma membrane Ca2+ channels molecularly mediate SOCE. Here we investigate the role of the microRNA machinery in regulating STIM1 expression. We show that STIM1 expression is regulated post-transcriptionally by the miRNA machinery and identify miR-223 and miR-150 as regulators of STIM1 expression in the luminal non-aggressive MCF7 breast cancer cell line. In contrast, STIM1 expression in the more aggressive basal triple-negative MDA-MB-231 cell line is not significantly modulated by a single miRNA species but is rather upregulated due to inhibition of the miRNA machinery through downregulation of Ago2. Consistently, overexpression of Ago2 results in decreased STIM1 protein levels in MDA-MB-231 cells. Clinically, STIM1 and Ago2 expression levels do not correlate with breast cancer progression, however in the basal subtype high STIM1 expression is associated with poorer survival. Our findings show that STIM1 expression is differentially regulated by the miRNA machinery in different cell types and argue for a role for this regulation in breast cancer.
Cyclic Peptide Stabilized Lead Halide Perovskite Nanoparticles
Authors: Jancik Prochazkova Anna , Salinas Yolanda , Yumusak Cigdem , Brüggemann Oliver , Weiter Martin , Sariciftci Niyazi Serdar , Krajcovic Jozef , Kovalenko Alexander 
Published: September 2019

AbstractCombining the unique properties of peptides as versatile tools for nano- and biotechnology with lead halide perovskite nanoparticles can bring exceptional opportunities for the development of optoelectronics, photonics, and bioelectronics. As a first step towards this challenge sub 10 nm methylammonium lead bromide perovskite colloidal nanoparticles have been synthetizes using commercial cyclic peptide Cyclo(RGDFK), containing 5 amino acids, as a surface stabilizer. Perovskite nanoparticles passivated with Cyclo(RGDFK) possess charge transfer from the perovskite core to the peptide shell, resulting in lower photoluminescence quantum yields, which however opens a path for the application where charge transfer is favorable.
Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients
Authors: Pintarelli Giulia , Noci Sara , Maspero Davide , Pettinicchio Angela , Dugo Matteo , De Cecco Loris , Incarbone Matteo , Tosi Davide , Santambrogio Luigi , Dragani Tommaso A. , Colombo Francesca 
Published: September 2019

AbstractAlterations in the gene expression of organs in contact with the environment may signal exposure to toxins. To identify genes in lung tissue whose expression levels are altered by cigarette smoking, we compared the transcriptomes of lung tissue between 118 ever smokers and 58 never smokers. In all cases, the tissue studied was non-involved lung tissue obtained at lobectomy from patients with lung adenocarcinoma. Of the 17,097 genes analyzed, 357 were differentially expressed between ever smokers and never smokers (FDR < 0.05), including 290 genes that were up-regulated and 67 down-regulated in ever smokers. For 85 genes, the absolute value of the fold change was ≥2. The gene with the smallest FDR was MYO1A (FDR = 6.9 × 10−4) while the gene with the largest difference between groups was FGG (fold change = 31.60). Overall, 100 of the genes identified in this study (38.6%) had previously been found to associate with smoking in at least one of four previously reported datasets of non-involved lung tissue. Seven genes (KMO, CD1A, SPINK5, TREM2, CYBB, DNASE2B, FGG) were differentially expressed between ever and never smokers in all five datasets, with concordant higher expression in ever smokers. Smoking-induced up-regulation of six of these genes was also observed in a transcription dataset from lung tissue of non-cancer patients. Among the three most significant gene networks, two are involved in immunity and inflammation and one in cell death. Overall, this study shows that the lung parenchyma transcriptome of smokers has altered gene expression and that these alterations are reproducible in different series of smokers across countries. Moreover, this study identified a seven-gene panel that reflects lung tissue exposure to cigarette smoke.
In situ characterization of the high pressure – high temperature melting curve of platinum
Authors: Anzellini Simone , Monteseguro Virginia , Bandiello Enrico , Dewaele Agnès , Burakovsky Leonid , Errandonea Daniel 
Published: September 2019

AbstractIn this work, the melting line of platinum has been characterized both experimentally, using synchrotron X-ray diffraction in laser-heated diamond-anvil cells, and theoretically, using ab initio simulations. In the investigated pressure and temperature range (pressure between 10 GPa and 110 GPa and temperature between 300 K and 4800 K), only the face-centered cubic phase of platinum has been observed. The melting points obtained with the two techniques are in good agreement. Furthermore, the obtained results agree and considerably extend the melting line previously obtained in large-volume devices and in one laser-heated diamond-anvil cells experiment, in which the speckle method was used as melting detection technique. The divergence between previous laser-heating experiments is resolved in favor of those experiments reporting the higher melting slope.
Ytterbium-doped fiber laser as pulsed source of narrowband amplified spontaneous emission
Authors: Muniz-Cánovas Pablo , Barmenkov Yuri O. , Kir’yanov Alexander V. , Cruz José L. , Andrés Miguel V. 
Published: September 2019

AbstractWe report random noise pulsed regime of an ytterbium-doped fiber laser arranged in common Fabry-Perot configuration. We show that the laser output obeys the photon statistics inherent to narrowband amplified spontaneous emission and that the noise pulsing is properly addressed in terms of probability density and autocorrelation functions. Our novel approach reveals, in particular, that the regime’s coherence time dramatically shortens, from few ns to tens ps, with increasing laser power.
Kaempferol derivatives isolated from Lens culinaris Medik. reduce DNA damage induced by etoposide in peripheral blood mononuclear cells
Authors: Kluska Magdalena , Juszczak Michał , Wysokiński Daniel , Żuchowski Jerzy , Stochmal Anna , Woźniak Katarzyna 
Published: September 2019

Abstract
Bioactive compounds isolated from plants are considered to be attractive candidates for cancer therapy. In this study, we examined the effect of kaempferol, its derivatives, the polyphenol fraction (PF) and an extract (EX) isolated from the aerial parts of Lens culinaris Medik. on DNA damage induced by etoposide in human cells. We also studied the effect of these compounds and their combinations on cell viability. The studies were conducted on HL-60 cells and human peripheral blood mononuclear cells (PBMCs). We used the comet assay in the alkaline version to evaluate DNA damage. To examine cell viability we applied the trypan blue exclusion assay. We demonstrated that kaempferol glycoside derivatives isolated from the aerial parts of Lens culinaris Medik. reduce DNA damage induced by etoposide in PBMCs, but do not have an impact on DNA damage in HL-60 cells. We also showed that kaempferol induces DNA damage in HL-60 cells and leads to an increase of DNA damage provoked by etoposide. Our data suggest that kaempferol derivatives can be further explored as a potential agent protecting normal cells against DNA damage induced by etoposide. Moreover, kaempferol's ability to induce DNA damage in cancer cells and to increase DNA damage caused by etoposide may be useful in designing and improving anticancer therapies.
Origin of the system of globular clusters in the Milky Way
Authors: Massari D. , Koppelman H. H. , Helmi A. 
Published: September 2019

Context. The assembly history experienced by the Milky Way is currently being unveiled thanks to the data provided by the Gaia mission. It is likely that the globular cluster system of our Galaxy has followed a similarly intricate formation path.
Aims. To constrain this formation path, we explore the link between the globular clusters and the known merging events that the Milky Way has experienced.
Methods. To this end, we combined the kinematic information provided by Gaia for almost all Galactic clusters, with the largest sample of cluster ages available after carefully correcting for systematic errors. To identify clusters with a common origin we analysed their dynamical properties, particularly in the space of integrals of motion.
Results. We find that about 40% of the clusters likely formed in situ. A similarly large fraction, 35%, appear to be possibly associated to known merger events, in particular to Gaia-Enceladus (19%), the Sagittarius dwarf galaxy (5%), the progenitor of the Helmi streams (6%), and to the Sequoia galaxy (5%), although some uncertainty remains due to the degree of overlap in their dynamical characteristics. Of the remaining clusters, 16% are tentatively associated to a group with high binding energy, while the rest are all on loosely bound orbits and likely have a more heterogeneous origin. The resulting age–metallicity relations are remarkably tight and differ in their detailed properties depending on the progenitor, providing further confidence on the associations made.
Conclusions. We provide a table listing the likely associations. Improved kinematic data by future Gaia data releases and especially a larger, systematic error-free sample of cluster ages would help to further solidify our conclusions.
GALACTICNUCLEUS: A high-angular-resolution JHKs imaging survey of the Galactic centre
Authors: Nogueras-Lara F. , Schödel R. , Gallego-Calvente A. T. , Dong H. , Gallego-Cano E. , Shahzamanian B. , Girard J. H. V. , Nishiyama S. , Najarro F. , Neumayer N. 
Published: September 2019

Context. The high extinction and extreme source crowding of the central regions of the Milky Way are serious obstacles to the study of the structure and stellar population of the Galactic centre (GC). Existing surveys that cover the GC region (2MASS, UKIDSS, VVV, SIRIUS) do not have the necessary high angular resolution. Therefore, a high-angular-resolution survey in the near infrared is crucial to improve the state of the art.
Aims. Here, we present the GALACTICNUCLEUS catalogue, a near infrared JHKs high-angular-resolution (0.2″) survey of the nuclear bulge of the Milky Way.
Methods. We explain in detail the data reduction, data analysis, calibration, and uncertainty estimation of the GALACTICNUCLEUS survey. We assess the data quality comparing our results with previous surveys.
Results. We obtained accurate JHKs photometry for ∼3.3 × 106 stars in the GC detecting around 20% in J, 65% in H, and 90% in Ks. The survey covers a total area of ∼0.3 deg2, which corresponds to ∼6000 pc2. The GALACTICNUCLEUS survey reaches 5σ detections for J ∼ 22 mag, H ∼ 21 mag, and Ks ∼ 21 mag. The uncertainties are below 0.05 mag at J ∼ 21 mag, H ∼ 19 mag, and Ks ∼ 18 mag. The zero point systematic uncertainty is ≲0.04 mag in all three bands. We present colour–magnitude diagrams for the different regions covered by the survey.
MRI Brain Changes After Marathon Running: Results of the Berlin Beat of Running Study
Authors: Herm Juliane , Haeusler Karl Georg , Kunze Claudia , Krüll Matthias , Brechtel Lars , Lock Jürgen , Heuschmann Peter U. , Haverkamp Wilhelm , Heekeren Hauke , Liman Thomas , Endres Matthias , Fiebach Jochen B. , Jungehulsing Gerhard Jan 
Published: September 2019

AbstractSeveral studies report neurological complications such as brain injury induced by ischemia or edema following exhaustive endurance sport. We aimed to detect the frequency of acute brain lesions after a marathon race. In the prospective observational Berlin Beat of Running study, 110 experienced endurance athletes underwent 3-Tesla brain MRI exams 2–3 days prior and within 2 days after a marathon run. MRI results were compared to an age- and sex-matched control group of 68 non-athletes, including the “Age-Related White Matter Changes” (ARWMC) scale to assess white matter lesions (WML) in the brain. 108 athletes (median age 48 years, 24% female, 8% with hypertension; 0% with diabetes) completed the race. No athlete reported neurological deficits, but a single acute ischemic lesion was detected in diffusion-weighted MRI after the race in one athlete. No other acute brain lesions compared to prior MRI were found. An ARWMC score ≥4 was found in 15% of athletes and 12% of non-athletic controls (p=0.7). Chronic ischemic lesions were not found in athletes but in four controls (6%) (p=0.02). In conclusion, acute ischemic brain lesions may be found in endurance runners. Every seventh endurance athlete and every ninth control showed evidence for substantial white matter lesions.
Die kognitive, sprachliche und motorische Entwicklung pränatal methamphetamin- und opioid-exponierter Kinder
Authors: Schreiter Juliane , Vogel Mandy , Kiep Henriette , Thome Ulrich , Bläser Annett , Nickel Petra , Kiess Wieland , Bernhard Matthias K. 
Published: September 2019

Zusammenfassung
Hintergrund Der Konsum illegaler Substanzen in der Schwangerschaft ist eine große gesellschaftliche und medizinische Herausforderung. Hauptproblemsubstanzen der pränatalen Drogenexposition sind neben Tetrahydrocannabinol (THC) Opioide und Methampehtamin. Die Wirkung dieser Substanzen auf die langfristige Entwicklung der Kinder ist noch vielfach unbekannt.
Methoden Seit 2012 werden am Universitätsklinikum Leipzig geborene Kinder mit pränataler Substanzexposition in der Kinderschutzambulanz langfristig nachbetreut. Von 42 Kindern mit pränataler Opioid- oder Methamphetaminexposition wurde im Alter von 2–3 Jahren eine Entwicklungsdiagnostik anhand der Bayley Scales (BSID III) durchgeführt. Als Kontrolle dienten 84 nicht exponierte Kinder. Das Matching erfolgte 1:2, adaptiert nach Alter, Geschlecht, Gestationsalter und Geburtsgewicht.
Ergebnisse Die motorische Entwicklung zwischen pränatal methamphetamin-, opioidexponierten Kindern und der Kontrollgruppe unterscheidet sich nicht signifikant. Die Kinder mit pränataler Methamphetaminexposition (n=23) zeigen jedoch signifikant geringere Skalenwerte in Kognition und Sprache (79,1 gegenüber 95,9 der Kontrollgruppe), pränatal opioidexponierte Kinder eine leichtere kognitive Einschränkung mit einem Skalenwert von 91,7 (n=19). 56% der Kinder der Methamphetamin-Gruppe hatten formal eine Entwicklungsverzögerung zum Testzeitpunkt. Zusätzlich erreichten Kinder signifikant niedrigere Skalenwerte, deren Bezugsperson alleinerziehend und/oder eine geringe schulische und berufliche Bildung hatten. Beide Substanzen erhöhten trotz gleichem Gestationsalter in allen Gruppen (37,4–38,5 SSW) das Auftreten postnataler Adaptionsstörungen erheblich (46–53%).
Schlussfolgerung Aus dieser Studie ergeben sich Hinweise darauf, dass Kinder mit pränataler Exposition gegenüber Methamphetamin oder Opioiden kognitive und sprachliche Defizite mit 2–3 Jahren zeigen und Methamphetamin einen stärkeren negativen Einfluss zu haben scheint. Die mit elterlichen Drogenabusus verbundenen psychosozialen Risikofaktoren haben dabei eine entscheidende Bedeutung für das Erreichen einer altersgerechten Entwicklung.
ERCP assessment tool: evidence of validity and competency development during training
Authors: Siau Keith , Dunckley Paul , Feeney Mark , Johnson Gavin ,   on behalf of the Joint Advisory Group on Gastrointestinal Endoscopy
Published: September 2019

Abstract
Background The endoscopic retrograde cholangiopancreatography (ERCP) direct observation of procedural skills (DOPS) is a 27-item competency assessment tool that was developed to support UK ERCP training. We evaluated validity of ERCP DOPS and competency development during training.
Methods This prospective study analyzed ERCP DOPS performed in the UK between July 2016 and October 2018. Reliability was measured using Cronbach’s alpha, and DOPS scores were benchmarked using the contrasting groups method. The percentage of competent scores was averaged for each item, domain, and overall rating, and stratified by lifetime procedure count to evaluate learning curves. Multivariable analyses were performed to identify predictors of DOPS competence.
Results 818 DOPS (109 trainees, 80 UK centers) were analyzed. Overall Cronbach’s alpha was 0.961. Attaining competency in 87 % of assessed DOPS items provided the optimal competency benchmark. This was achieved in the domain sequence of: pre-procedure, post-procedure management, endoscopic non-technical skills, cannulation & imaging, and execution of selected therapy, and across all items after 200 – 249 procedures (89 %). After 300 procedures, the benchmark was reached for selective cannulation (89 %), but not for stenting (plastic 73 %; metal 70 %), sphincterotomy (80 %), and sphincteroplasty (56 %). On multivariable analysis, lifetime procedure count (P = 0.002), easier case difficulty (P < 0.001), trainee grade (P = 0.03), and higher lifetime DOPS count (P = 0.01) were predictors of DOPS competence.
Conclusion This study provides novel validity, reliability, and learning curve data for ERCP DOPS. Trainees should have a minimum of 300 hands-on ERCP procedures before undertaking summative assessment for independent practice.
Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study
Authors: Rastinehad Ardeshir R. , Anastos Harry , Wajswol Ethan , Winoker Jared S. , Sfakianos John P. , Doppalapudi Sai K. , Carrick Michael R. , Knauer Cynthia J. , Taouli Bachir , Lewis Sara C. , Tewari Ashutosh K. , Schwartz Jon A. , Canfield Steven E. , George Arvin K. , West Jennifer L. , Halas Naomi J. 
Published: September 2019

Significance
Prostate cancer is the most common nonskin cancer in the United States, where approximately 1 in 9 men will be diagnosed in their lifetime. The prostate is near several vital structures, such as the urethra and neurovascular bundle, and whole gland treatments for prostate cancer can disrupt normal urinary, bowel, and sexual functioning. Here we report the initial results of a clinical trial for nanoparticle-based photothermal cancer therapy. The trial was designed to perform ultrafocal photothermal ablation of cancerous tumors within the prostate. Gold-silica nanoparticles designed to absorb near-infrared light at wavelengths of high tissue transparency provide a highly localized light-based strategy for the treatment of prostate cancer, with substantially reduced risks for deleterious treatment-related side effects.
Performing (in) places, moralizing (through) spaces
Authors: Martínez Guillem Susana 
Published: September 2019

AbstractThis paper offers an account of the co-constitutive interaction between spatial and discursive dynamics in present-day politics. I focus on Podemos, a recently established party in Spain that was able to secure 20% of votes in the 2016 general election. Building on critical geography’s political understanding of space, together with cultural and discourse studies’ insights on place representation, formulation, and embodiment, I examine Podemos’ parliamentary performances, as well as their different moral evaluations by opposing parties. Throughout my analysis, I show, first, that the transgressive nature of certain acts is intrinsically linked to the particular spatial relations enforced in institutional contexts, and second, how, in their discursive struggles over common sense, different actors consistently mobilize space as a moralizing agent. The different strategies adopted reveal a tension between dominant and emergent ways of ‘doing politics’ that parallels competing visions of the relationship, in contemporary Spain, between civic and institutional spaces.
On the translation of Manner-of-motion in comics
Authors: Molés-Cases Teresa 
Published: September 2019

AbstractThis paper focuses on the translation of Manner-of-motion in comics, a genre in which information is conveyed in both verbal and visual language. The study draws on Slobin’s Thinking-for-translating hypothesis, according to which translators tend to distance themselves from the source text in order to conform to the rhetorical style of the target language. Special attention is devoted to the role of visual language within this framework, with the ultimate aim of identifying translation techniques adapted to the issue of translating Manner-of-motion in comics, in both inter- and intratypological translation scenarios. This paper analyses a corpus that includes a selection from the Belgian comic seriesLes aventures de Tintinand its translation into two satellite-framed languages (English and German) and two verb-framed languages (Spanish and Catalan). Overall, the results highlight the key role of visual language in the translation of Manner-of-motion in comics, since this can compensate for alterations in the verbal code of target texts, by comparison with originals, and thus minimize the consequences of Thinking-for-translating. Moreover, the (limited) space in the balloons and the respective stylistic conventions of comic books in each language are shown to constrain translation to some extent.