bluuebunny/crossref_metadata_2025_split huggingface dataset:
Narrative Investigation
Authors: Kennedy Meegan 
Published: December 2024

Abstract
Victorian researchers used a technique I call narrative investigation to manage the interrelation of skepticism and wonder within a story arc that ties together the investigator’s varied experiences of physical, visual, attentional, and intellectual mobility. Narrative investigation casts the original investigator as an explorer moving through strange landscapes. The narrative offers a virtual storyspace wherein readers can mentally inhabit that role, tracing exactly each step in the investigator’s rhythm of focused practice and reflection, movement and stasis, eventually to reproduce these actions in person. These narratives deploy techniques of suspense that dramatize the wave-like, intermittent rhythm of attention and reflection as theorized by the physiological psychologists, and they showcase the microscopical revelations that reward the persistent investigator. Even in research texts, these moments of reflective appreciation invite readers to mirror the speaker’s affective responses.
Lines of Fate
Authors: Miller Ian M , Coggins Chris 
Published: December 2024

Abstract
This article explores the concept of resilience within the framework of fengshui forests in subtropical southern China over the last millennium. Consisting of small patches of old-growth or old secondary-growth forest associated with graves, temples, and the paths of wind and water into and out of villages, fengshui forests were historically seen as nodes that supplied vital qi(energy, force or substance) to the community, an understanding that persists to the present day. Using a combination of textual, ethnographic, and scientific evidence, we examine how these forests, deeply embedded in the cultural and ecological fabric of the region, have fostered community resilience and sustainability over centuries. We show that fengshui’s vitalist and syncretic conception of the relationship among living people, ancestors, the land, and the trees allowed it to bridge Indigenous and imperial moral ecologies. By foregrounding both the emic and etic implication of fengshui, this article contributes to our understanding of Indigenous moral ecologies, the histories of social-ecological resilience, and the role of sacred forests in sustaining biodiversity and community well-being, past and present.
Career pathways into the medical laboratory workforce: Education, exposures, and motivations
Authors: Guenther Grace A , Shahrir Shahida F , Skillman Susan M , Kundu Iman , Garcia Edna , Frogner Bianca K 
Published: December 2024

Abstract

Objectives
The goal of this study was to investigate career pathways into the medical laboratory workforce by examining medical laboratory scientists, medical laboratory technicians, histotechnologists, histotechnicians, cytologists, and phlebotomists.

Methods
We collected data through an anonymous online survey (May-June 2023) from a convenience sample of medical laboratory professionals in the United States (N = 1243). We performed descriptive analyses of demographics, current employment characteristics, educational and training history, career exposures, motivations, movement, and outlook (eg, job satisfaction, future career plans).

Results
Findings show a diverse range of educational backgrounds and varying career pathways across occupations. A majority of respondents reported hearing about laboratory occupations from friends, family, co-workers, and acquaintances. At least one-third to nearly one-half of respondents had a family member with broader professional health care experience. Respondents viewed their jobs favorably, with at least 75% of respondents answering that they would recommend their occupation or another laboratory occupation.

Conclusions
This study found overall positive job experiences and satisfaction, but career pathways into medical laboratory occupations are complex and often unclear. Organizations in the field are undertaking promotional efforts to increase the visibility of these occupations. Future research is needed to monitor and evaluate these efforts.
Changes in US drinking and alcohol use disorders associated with social, health, and economic impacts of COVID-19
Authors: Kerr William C , Ye Yu , Martinez Priscilla , Karriker-Jaffe Katherine J , Patterson Deidre , Greenfield Thomas K , Mulia Nina 
Published: December 2024

Abstract

Aims
The COVID-19 pandemic increased alcohol consumption in the USA as a result of widespread individual changes in drinking patterns. Few studies have utilized longitudinal data allowing the prediction of increased or decreased drinking from COVID-19 economic, social, and health impacts.

Methods
Data are from 1819 respondents in the 2019–20 National Alcohol Survey and a one-year follow-up in early 2021. Changes in past-year alcohol volume, drinking days, days with 5+ drinks, and Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) alcohol use disorder (AUD) severity were measured as outcomes. Measures of COVID-19 economic, health, and social impacts were assessed for the individual and household. Economic impacts were combined into Self and Household scores. Analyses utilized multinomial logistic regression models to estimate meaningful increases or decreases in outcomes, while generalized estimating equation models estimated overall effects.

Results
Increases in alcohol use and AUD severity were larger and more prevalent than decreases, and differences between sociodemographic groups in the prevalence of meaningful increases and decreases were found. Models of meaningful changes found that higher self-economic impact scores predicted increases in 5+ days and AUD severity. Generalized estimating equation models also found that the self-economic impact score predicted increased AUD severity and additionally that being an essential worker was associated with reductions in alcohol volume and 5+ days.

Conclusions
Substantial changes in drinking and AUD severity were observed, with increases in these outcomes being more prevalent and larger than decreases. Results highlight the importance of the pandemic’s economic impacts in predicting changes in drinking and AUD severity.
The effects of previous detoxifications on intelligence, speed, attention, and executive functioning in patients with moderate to severe alcohol use disorder
Authors: Staudt Jeroen , De Haan Hein , Walvoort Serge , Rensen Yvonne , Egger Jos , Dijkstra Boukje 
Published: December 2024

Abstract

Introduction and aims
Repeatedly undergoing supervised, medical, detoxification from chronic alcohol use may contribute to impairments in neurocognitive functioning of patients with an alcohol use disorder (AUD). Unsupervised, non-medical, detoxification, however, may also contribute to neurocognitive impairments, given the absence of first choice prescription medication to counteract severe withdrawal effects. So far, findings from previous studies are inconclusive and specifically effects of non-medical detoxifications are not investigated yet. Using an association modeling approach, this study investigates whether intelligence, speed, attention, and executive functioning are influenced by previous medical and/or non-medical detoxifications.

Methods
A total of 106 participants with AUD underwent a clinical medical supervised detoxification. Basic characteristics of the patient were recorded including the number of previous medical and non-medical detoxifications. Neuropsychological assessment was conducted after 6 weeks of abstinence.

Results
The amount of previous medical detoxifications (F (1, 87) = 4.108, P = .046) and the group of medical detoxifications (F(1, 87) = 4734, P = .032), predicted performance on one out of 14 dependent variables, i.e. the “d2 Number of Signs” task. Though “Age of onset of daily alcohol use” contributed significantly to this relationship, the change of the regression coefficient of the model was ˂10%. The number of non-medical or total amount of previous detoxifications did not predict any of the dependent variables.

Conclusion
The results indicate limited evidence of a linear association between either medical, non-medical, or total amount of previous detoxifications and measures of intelligence, speed, attention, or executive functioning, while controlling for relevant confounders.
Surgical Site Allergic Contact Dermatitis Due to 2-Octyl Cyanoacrylate: A Systematic Review and FDA MAUDE Review
Authors: Fanning James E , Escobar-Domingo Maria J , Montoya Marco , Foppiani Jose , Lee Daniela , Park John B , Rahmani Benjamin , Miller Amitai S , Karinja Sarah J , Boustany Ashley N , Tan Sally Y , Lee Bernard T 
Published: December 2024

Abstract

Skin adhesives containing 2-octyl cyanoacrylate are a common source of allergic contact dermatitis (ACD), a complication of postoperative wound healing. Few studies have described postoperative cutaneous reactions to skin adhesives and their clinical management. The aim of this study was to review the incidence, descriptions, and clinical management of surgical site ACD caused by 2-ocyl cyanoacrylate. A comprehensive systematic literature search was conducted in September 2023 of the PubMed/MEDLINE (National Library of Medicine, Bethesda, MD), Web of Science (Clarivate Analytics, Philadelphia, PA), and Cochrane databases (Cochrane Library, John Wiley & Sons, Ltd., Hoboken, NJ) for studies reporting ACD after skin closure with liquid adhesives containing 2-octyl cyanoacrylate. Additionally, we queried the FDA Manufacturer and User Facility Device Experience (FDA MAUDE, U.S. Food and Drug Administration, Silver Spring, MD) in September 2023 and retrieved clinician-inputted records of ACD caused by liquid adhesives containing 2-octyl cyanoacrylate from 2014 to2023. Nine articles were included for review, with a median of 102 patients exposed to 2-octyl cyanoacrylate for surgical site skin closure. The reported incidence of cutaneous reactions to 2-octyl cyanoacrylate ranged from 0.5% to 14%. The review also included 609 unique FDA MAUDE records reporting surgical site skin reactions to 2-octyl cyanoacrylate. Orthopedic procedures were the most common type of procedure, representing 47% of FDA MAUDE records. Nineteen clinical descriptors of cutaneous reactions were utilized. Topical corticosteroids and oral antihistamines were the most commonly prescribed treatments to manage postoperative cutaneous reactions. Reported incidences of cutaneous reactions to 2-octyl cyanoacrylate vary widely and guidelines for clinical management remain unclear. The FDA MAUDE provides important insights to cutaneous reactions to 2-octyl cyanoacrylate including surgery-type, cutaneous descriptors, and clinical management. Future research is needed to identify patients at risk of 2-octyl cyanoacrylate skin reactions in the preoperative setting.

Level of Evidence: 3 (Therapeutic)
Comprehensive bioinformatics and machine learning analyses for breast cancer staging using TCGA dataset
Authors: Das Saurav Chandra , Tasnim Wahia , Rana Humayan Kabir , Acharjee Uzzal Kumar , Islam Md Manowarul , Khatun Rabea 
Published: December 2024

Abstract
Breast cancer is an alarming global health concern, including a vast and varied set of illnesses with different molecular characteristics. The fusion of sophisticated computational methodologies with extensive biological datasets has emerged as an effective strategy for unravelling complex patterns in cancer oncology. This research delves into breast cancer staging, classification, and diagnosis by leveraging the comprehensive dataset provided by the The Cancer Genome Atlas (TCGA). By integrating advanced machine learning algorithms with bioinformatics analysis, it introduces a cutting-edge methodology for identifying complex molecular signatures associated with different subtypes and stages of breast cancer. This study utilizes TCGA gene expression data to detect and categorize breast cancer through the application of machine learning and systems biology techniques. Researchers identified differentially expressed genes in breast cancer and analyzed them using signaling pathways, protein–protein interactions, and regulatory networks to uncover potential therapeutic targets. The study also highlights the roles of specific proteins (MYH2, MYL1, MYL2, MYH7) and microRNAs (such as hsa-let-7d-5p) that are the potential biomarkers in cancer progression founded on several analyses. In terms of diagnostic accuracy for cancer staging, the random forest method achieved 97.19%, while the XGBoost algorithm attained 95.23%. Bioinformatics and machine learning meet in this study to find potential biomarkers that influence the progression of breast cancer. The combination of sophisticated analytical methods and extensive genomic datasets presents a promising path for expanding our understanding and enhancing clinical outcomes in identifying and categorizing this intricate illness.
Fire metaphors in Plutarch’s Late Republican Lives
Authors: Deriu Morena 
Published: December 2024

ABSTRACT
In this article, I will investigate how Plutarch uses fire metaphors to conceptualize physical and psychological realities mainly related to the exercise of power in the Lives belonging to the Late Republic and their parallel Lives. I will show how Plutarch uses fire as a source domain to represent the target domains of war and conflict, anger, ambition, and warlike ardour, and erotic desire. I will point out the similarities and differences in such uses to illustrate how these target domains do or do not overlap. My aim is to show how fire metaphors contribute to Plutarch’s evaluation of his heroes, further illuminating the light and shade through which he famously characterizes his protagonists. Since the Lives programmatically provides its readers with models to follow and to avoid, a new understanding of Plutarch’s fire metaphors will also contribute to an improved perception of Plutarch’s protreptic purpose as regards the way his readers should handle the most burning emotions in the system of imperial authority and power. As people hopefully engaged in a long-lasting and noteworthy political career in this system, Plutarch wanted them educated in how to handle and exploit such emotions.
Preliminary urinary profiles of prolactin during gestation and the synergistic effects of embryonic diapause hormones in the giant panda (Ailuropoda melanoleuca)
Authors: Shenfei Wang , Mengshi Zhang , Feiping Li , Xianbiao Hu , Yan Li , Juan Wang , Xiangyu Liu , Rong Hou , Yuliang Liu , Kailai Cai 
Published: December 2024

Abstract
The embryonic diapause of the giant panda (Ailuropoda melanoleuca) has caused great difficulties in monitoring pregnancy in this vulnerable species. The secretion of prolactin (PRL) from anterior pituitary glandular lactotropic cells is an important signal for the termination of embryonic dormancy. Currently, the mechanism by which PRL affects embryonic diapause in giant pandas and methods for detecting PRL in this species is poorly understood. In this study, the first sandwich enzyme immunoassay for detecting PRL in giant panda urine was established by using two antigiant panda PRL antibodies prepared as coating and labeling antibodies, and PRL recombinant proteins prepared via the prokaryotic system as standards. The established method was used to detect the levels of PRL in the urine of giant pandas during pregnancy. At the same time, the changes in PRL levels in giant pandas and the relationship between PRL and progestagen levels were analyzed during the luteal phase. The results showed that in female giant pandas, PRL levels significantly increased before the progestagen peak, and during the luteal phase, the PRL level was significantly greater in giant pandas that gave birth than in those that did not give birth and those in the nonestrus group. To the best of our knowledge, this is the first study to preliminarily explore the mode of action of PRL in the gestation period of giant pandas and lays a foundation for further study of the regulatory mechanisms of endocrine hormones in the giant panda.
Queering Crime Reporting: Representing Anti-queer Violence in LGBTQ News Media
Authors: Mitchell Matthew , O’Neill Tully , Redd Curtis 
Published: December 2024

Abstract
While criminology has studied news media reporting for decades, it has largely overlooked reporting on anti-queer violence and depictions of crime outside mainstream outlets. This article addresses this gap by analysing how anti-queer violence is represented in LGBTQ community media. By analysing 1,295 articles from 11 LGBTQ publications across five Anglophone countries between 2019 and 2021, we examine which forms of anti-queer violence are deemed newsworthy in these outlets. Our analysis reveals that LGBTQ community media emphasize particular types of violence, relationships between victims and perpetrators and contexts of victimization while downplaying or disregarding others. We argue that this selective representation both mirrors and ‘queers’ prevailing norms in mainstream crime news reporting in culturally and criminologically significant ways. In grappling with this tension, we identify and critique several cisheteronormative assumptions embedded in the existing literature on news media representations of crime. Ultimately, our analysis calls for a re-evaluation and revision of the existing discourse within media criminology, urging scholars to engage with a broader range of experiences, communities and narrative practices to understand better how violence is culturally mediated.
Patient preferences for the treatment of Bowen disease
Authors: Ahmady Shima , Mosterd Klara , Jansen Maud H E , Kelleners-Smeets Nicole W J , Essers Brigitte A B 
Published: December 2024

Abstract

Background
Discrete choice experiments (DCEs) are increasingly used to understand and quantify patient preferences for a variety of treatments, services or screening in order to analyse the choices patients make when faced with different alternatives.

Objectives
The aim of this DCE was to examine patient preferences for the treatment of Bowen disease.

Methods
A DCE was conducted alongside a randomized controlled noninferiority trial comparing the effectiveness of surgical excision, methyl aminolaevulinate photodynamic therapy (MAL-PDT) and 5-fluorouracil (5-FU) cream as treatments for Bowen disease. Preferences were elicited by presenting patients with choice tasks between surgical excision, MAL-PDT and 5-FU cream with the following attributes: effectiveness, cosmetic outcome, side-effects, treatment duration and process. A mixed logit model was used to account for the panel nature of the data (repeated choices for each respondent) and heterogeneity in preference.

Results
A total of 215 patients completed the DCE. Patients have a clear preference for excision and noninvasive therapies were less valued, as indicated by the large and negative label effect. Both moderate and good-to-excellent cosmetic outcomes were accepted and preferred to poor cosmetic outcomes for all treatments. In addition, none or mild-to-moderate side-effects were considered acceptable and preferred to severe side-effects.

Conclusions
Patients show a clear preference for surgical excision, and of the two noninvasive treatments, 5-FU cream is preferred to MAL-PDT. Treatment choice is also determined by attributes such as effectiveness, cosmetic outcome and side-effects. In the context of shared decision making for Bowen disease, it is important to discuss the elements of treatment that patients value to ensure that an informed decision is made.
Epidemiology and Outcomes of Antibiotic De-escalation in Patients With Suspected Sepsis in US Hospitals
Authors: Kam Kai Qian , Chen Tom , Kadri Sameer S , Lawandi Alexander , Yek Christina , Walker Morgan , Warner Sarah , Fram David , Chen Huai-Chun , Shappell Claire N , DelloStritto Laura , Jin Robert , Klompas Michael , Rhee Chanu 
Published: December 2024

Abstract

Background
Little is known about the frequency, hospital-level variation, predictors, and outcomes of antibiotic de-escalation in suspected sepsis.

Methods
We retrospectively analyzed adults admitted to 236 US hospitals from 2017–2021 with suspected sepsis (defined by blood culture draw, lactate measurement, and intravenous antibiotic administration) who were initially treated with ≥2 days of anti–methicillin-resistant Staphylococcus aureus (MRSA) and anti-pseudomonal antibiotics but had no resistant organisms that required these agents identified through hospital day 4. De-escalation was defined as stopping anti-MRSA and anti-pseudomonal antibiotics or switching to narrower antibiotics by day 4. We created a propensity score for de-escalation using 82 hospital and clinical variables; matched de-escalated to non–de-escalated patients; and assessed associations between de-escalation and outcomes.

Results
Among 124 577 patients, antibiotics were de-escalated in 36 806 (29.5%): narrowing in 27 177 (21.8%), cessation in 9629 (7.7%). De-escalation rates varied between hospitals (median, 29.4%; interquartile range, 21.3%–38.0%). Predictors of de-escalation included less severe disease on day 3–4, positive cultures for nonresistant organisms, and negative/absent MRSA nasal swabs. De-escalation was more common in medium, large, and teaching hospitals in the Northeast and Midwest. De-escalation was associated with lower adjusted risks for acute kidney injury (AKI) (odds ratio [OR], 0.80; 95% confidence interval [CI], .76–.84), intensive-care unit (ICU) admission after day 4 (OR, 0.59; 95% CI, .52–.66), and in-hospital mortality (OR, 0.92; 95% CI, .86–.996).

Conclusions
Antibiotic de-escalation in suspected sepsis is infrequent, variable across hospitals, linked with clinical and microbiologic factors, and associated with lower risk for AKI, ICU admission, and in-hospital mortality.
Association Between the Sequence of β-Lactam and Vancomycin Administration and Mortality in Patients With Suspected Sepsis
Authors: Kondo Yutaka , Klompas Michael , McKenna Caroline S , Pak Theodore R , Shappell Claire N , DelloStritto Laura , Rhee Chanu 
Published: December 2024

Abstract

Background
Timely antibiotic initiation is critical to sepsis management, but there are limited data on the impact of giving β-lactams first versus vancomycin first among patients prescribed both agents.

Methods
We retrospectively analyzed all adults admitted to 5 US hospitals from 2015–2022 with suspected sepsis (blood culture collected, antibiotics administered, and organ dysfunction) treated with vancomycin and a broad-spectrum β-lactam within 24 hours of arrival. We estimated associations between β-lactam- versus vancomycin-first strategies and in-hospital mortality using inverse probability weighting (IPW) to adjust for potential confounders.

Results
Among 25 391 patients with suspected sepsis, 21 449 (84.4%) received β-lactams first and 3942 (15.6%) received vancomycin first. Compared with the β-lactam-first group, patients administered vancomycin first tended to be less severely ill, had more skin/musculoskeletal infections (20.0% vs 7.8%), and received β-lactams a median of 3.5 hours later relative to emergency department arrival. On IPW analysis, the β-lactam-first strategy was associated with lower mortality (adjusted odds ratio [aOR]: .89; 95% CI: .80–.99). Point estimates were directionally similar but nonsignificant in a sensitivity analysis using propensity score matching rather than IPW (aOR: .94; 95% CI: .82–1.07) and in subgroups of patients with positive blood cultures, methicillin-resistant Staphylococcus aureus cultures, and those administered antipseudomonal β-lactams.

Conclusions
Among patients with suspected sepsis prescribed vancomycin and β-lactam therapy, β-lactam administration before vancomycin was associated with a modest reduction in in-hospital mortality. These findings support prioritizing β-lactam therapy in most patients with sepsis but merit confirmation in randomized trials given the risk of residual confounding in observational analyses.