bluuebunny/crossref_metadata_2025_split huggingface dataset:
Augmented Reality Versus Freehand Spinopelvic Fixation in Spinal Deformity: A Case-Control Study
Authors: Azad Tej D. , Alfonzo Horowitz Melanie , Tracz Jovanna A. , Khalifeh Jawad M. , Liu Connor J. , Hughes Liam P. , Judy Brendan F. , Khan Majid , Bydon Ali , Witham Timothy F. 
Published: November 2024

Purpose This study sought to compare screw placement accuracy and outcomes between freehand (FH) and AR-guided pelvic fixation. While pelvic fixation is a critical technique in spinal deformity surgery, S2-alar iliac (S2AI) screw placement poses challenges. Methods We conducted a case-control study of 50 consecutive patients who underwent spinopelvic fixation at a single institution. AR guidance was performed using a head-mounted display (Xvision, Augmedics). Patient demographics, surgical characteristics, spinopelvic parameters, and screw breach grade were compared using univariate and multivariate statistics. Results Pelvic fixation was performed FH in 21 patients (median age, 64; female, 38.1%; median BMI 32.3 kg/m2) and AR-guided in 29 patients (median age, 66; female, 51.7%; median BMI 28.4 kg/m2). Mean follow-up was longer in the FH group (28 mos vs 11 mos, P < 0.001). Pelvic fixation in the FH group was performed using either S2AI (90.5%) or dual S2AI (9.5%) screws. There were no significant differences in length of surgery (FH, 439 minutes; AR, 490 minutes; P = 0.1) or estimated blood loss (FH, 2.1L; AR, 1.9L; P = 0.7). Accuracy of FH pelvic fixation was 95.6% (43/45 screws) and accuracy of AR pelvic fixation was 96.5% (55/57 screws). Multivariable logistic regression for screw breach revealed no significant association with AR guidance when controlling for age, BMI, osteoporosis, and smoking. Conclusions We present the first case-control study of AR-guided spinopelvic fixation, with findings suggesting parity between FH and AR-guidance, serving as foundation for prospective controlled studies with longitudinal follow-up to interrogate the benefits of AR-guidance in spinal deformity surgery.
Make the Right Call: formative evaluation for a water safety programme for adults in Western Australia
Authors: Leavy Justine E. , Abercromby Meg , Della Bona Malena , Nimmo Lauren , Crawford Gemma 
Published: November 2024

Background: Preventing drowning in adults is a complex, multifaceted injury prevention issue. The adult drowning rate in Australia is continuing to rise. In 2023, more than half of those who drowned were aged over 45 years. While there has been a call for robust, evidence-informed drowning prevention interventions across the life course, evidence of evaluated, drowning prevention programmes for adults is lacking. For more than a decade, drowning prevention researchers and practitioners in Western Australia (WA) have worked in partnership to design and evaluate evidence-informed programmes. This paper describes formative research to develop ‘Make the Right Call’ (MTRC), an adult water safety programme in WA. Methods: A staged, mixed-methods, formative evaluation was undertaken to inform the design of MTRC. Stages: The approach involved cluster analysis of coronial data 2008–2018 ( n = 93), interviews with adults aged 45–64 years ( n = 10) and 65 years and older ( n = 15), theory mapping, survey design, content and face validity testing of a baseline questionnaire with content experts ( n = 11) and a refined instrument to collect knowledge, and data on norms and water-based activity. The subsequent MTRC programme comprised a media campaign, community swimming and safety classes, lifejacket trade-in, subsidised first-aid training and community education. Discussion: The results of each stage informed the design and evaluation of a new evidence-informed and theory-driven drowning prevention programme for adults aged 45 years and older, delivered by the peak drowning prevention agency in WA, Royal Life Saving Western Australia. An investment in mixed-methods research by the partnership added rigour and credibility to the programme and evaluation design. Conclusion: To the best of our knowledge, this is the first adult water safety programme to apply a theory-driven, evidence-informed approach to its development, implementation and evaluation. The partnership was vital in maximising and accelerating the acceptable transfer of results to enhance knowledge creation and, ultimately, the design of the MTRC drowning prevention programme.
Predictive value of serum interleukin-6 for neonatal encephalopathy outcomes
Authors: Saito Junichi , Shibasaki Jun , Yamamoto Kouji , Fujita Maya , Toyoshima Katsuaki 
Published: November 2024

Background: Serum interleukin-6 (IL-6) may predict adverse outcomes of neonatal encephalopathy (NE); however, limited data regarding the predictive utility of IL-6 during neurodevelopmental follow-up are available. We aimed to determine the utility of IL-6 for predicting adverse outcomes at 18 to 22 months of age. Methods: Eighty-seven patients with NE who received therapeutic hypothermia were enrolled in this study. Serial serum IL-6 levels during the first 3 postnatal days were collected. Patients were classified into three groups: (1) death, (2) survival with moderate to severe neurodevelopmental disability (NDD) at 18–22 months of age, and (3) survival without NDD (favorable outcome). The predictive ability of IL-6 was determined by the area under the receiver-operating characteristic curve (AUC). Results: Serial IL-6 data of 80 patients with NE were available and showed peak levels on postnatal day 1; these levels gradually decreased toward day 3. By 18–22 months of age, 13 and 17 patients died and experienced moderate to severe NDD without death, respectively. Fifty patients experienced favorable outcomes. Higher IL-6 levels on day 1 predicted the composite adverse outcome (including death and survival with NDD; n = 30; AUC, 0.648). Higher IL-6 levels on day 1 predicted death ( n = 13; AUC, 0.799), whereas higher IL-6 levels on day 1 predicted survival with NDD ( n = 17; AUC, 0.536). Conclusions: The AUC of IL-6 that predicted survival with NDD was lower than the AUC of IL-6 that predicted death; therefore, IL-6 may have insufficient utility for predicting NDD without death.
The hidden factor in COVID-19 rehabilitation: how does the microenvironment in mobile cabin hospitals impact patient recovery? An observational study
Authors: Cheng Yang , Wen Ru , Wang Yuxiao , Sun Xinxin , Jiang Shan , Chen Zhiqiang , Yu Qiwei , Tan Liang , Zhang Liqiang , Tao Zhuolin , Xu Peng , Chen Dongdong , Yu Hong , Su Zuqiang , Chen Kang , Liu Yunsheng , Liu Chen 
Published: November 2024

Backgrounds: Existing studies on the treatment of emergency infectious diseases have primarily focused on the pathogen and the human immune system. However, human health is intricately connected to environmental factors, and this interaction becomes particularly during large-scale public health emergencies. Few studies have examined the impact of spatial differences in the microenvironment on the rehabilitation rate of patients with the Omicron variant infection. Objective: This study employs causal inference statistical methods and spatial analysis to investigate how the hospital microenvironment affects the rehabilitation of COVID-19 patients in a mobile cabin hospital, so as to provide a scientific basis for the spatial arrangement of patients in mobile cabin hospitals. Design: Observational study. Methods: This study used the clinical information of 6291 patients admitted in a mobile cabin hospital in Shanghai, from April 9 to May 9, 2022, during the pandemic. Exploratory spatial data analysis and fixed-effects regression analysis were conducted to understand whether the microenvironment around the patients’ beds in the cabin impacted their rehabilitation. Results: The results indicate that the rehabilitation condition of patients is affected by spatial differences of microenvironment. Both the mean and minimum CT values of the surrounding patients show a significant positive correlation with the rehabilitation of patients. The further the distance from the vent is, the more the rehabilitation speed of the patients is affected by the CT values of the surrounding patients. Conclusion: These findings offer valuable insights for bed allocation, patients’ stratification and management, and ventilation management in the mobile cabin hospitals during public health emergencies.
Fertility desire and associated factors among antiretroviral therapy users in South Gondar Zone, Northwest Ethiopia, 2022
Authors: Mitiku Assefa Kebie , Yirdaw Birhanu Wubale , Alem Hymanot , Ferede Wassie Yazie , Erega Besfat Berihun 
Published: November 2024

Introduction: There were approximately 38 million human immune deficiency virus/acquired immune deficiency syndrome cases worldwide in 2019, of which 36.2 million were adult cases, of these 25.4 million had access to antiretroviral therapy. The desire to have children among human immune virus-infected people has significant implications for the transmission of the human immune virus. In many developing countries such as Ethiopia, where the prevalence of the human immune virus is high, the risk of human immune virus transmission to the baby is inevitable. Objective: This study’s objective is to evaluate fertility desire and associated factors among antiretroviral therapy users at South Gondar public hospitals, Northwest Ethiopia, 2022. Methods: A multicenter institutional-based cross-sectional study design was conducted among patients attending antiretrio viral therapy at South Gondar Zone public hospitals, from April 1 to May 30, 2022. A total of 551 study participants were selected using systematic random sampling. Data were collected through face-to-face interviews using a pretested, semi-structured questionnaire. The data were entered into Epi-Data version 4.6 and then exported to SPSS version 26 for analysis. Multivariable logistic regression analysis was performed to identify factors associated with the outcome variable, and adjusted odds ratios with 95% confidence intervals were calculated to determine the level of significance. Result: The study included 551 participants with a 100% response rate. The prevalence of fertility desire among antiretroviral therapy users in South Gondar Zone public hospitals was 42.5% (95% confidence interval: 38.6, 46.8). Independent predictors of fertility desire included being a merchant (adjusted odds ratio = 0.06; 95% confidence interval: 0.01, 0.08), being a farmer (adjusted odds ratio = 0.21; 95% confidence interval: 0.09, 0.47), having no children (adjusted odds ratio = 20.04; 95% confidence interval: 4.7, 24.2), disclosing HIV status (adjusted odds ratio = 0.05; 95% confidence interval: 0.01, 0.30), and being diagnosed with HIV (adjusted odds ratio = 15.5; 95% confidence interval: 12.79, 20.54). Conclusions: The prevalence of fertility desire among antiretroviral therapy users is found to be high. It is important to improve the existing Information, Education, and Communication interventions on fertility desire among antiretroviral therapy attendants at the individual and community levels.
The lived experiences of mother’s caring for children with uncontrolled asthma: A qualitative study
Authors: Aldirawi Ali , Al Rawwad Tamara , Al-Qudimat Ahmad R , Jin Yan , Brooks Andrea , Eldeirawi Kamal 
Published: November 2024

Introduction: Childhood-onset asthma is a chronic respiratory disease that profoundly impacts patients, their families, and healthcare systems. This study explores the lived experiences, challenges, and perceptions of mothers in managing asthma, controlling symptoms, and maintaining the quality of life for their children with asthma in Palestine. Methods: A qualitative descriptive design through semi-structured interviews was used in this study. Purposive sampling was used to identify mothers who have children with severe uncontrolled asthma in the four public hospitals with pediatric units in the West Bank, Palestine. Mothers of children with scored below 15 on the asthma control test were included in the study. The data were analyzed using an analytical framework following a thematic analysis through the NVivo 11. Results: A total of 20 mothers participated in interviews wherein they delineated the most important challenges negatively affecting asthma management from mothers’ perspectives. These challenges encompassed frequent emergency room visits, improper medication administration practices, and limitations in physical activity. The mothers expressed concerns regarding asthma control, including anxieties concerning the chronicity of the illness, adverse effects of medications, and susceptibility to weather fluctuations. The main themes that emerged from the data included reduced quality of life for the child, parental responsibility for monitoring triggers, symptoms, and medications, challenges in asthma management, apprehensions regarding asthma control, and strategies for enhancing asthma management. Conclusion: This study emphasizes the pressing need for targeted interventions to address asthma management, environmental triggers, and psychosocial disruptions related to asthma in children with asthma to enhance the quality of life and asthma control. This study highlights the importance of developing strategies that provide mothers with the appropriate information and tools to navigate the complexities of caring for a child with asthma.
Virtual neurology survey: Factors influencing virtual care use among Ontario neurologists
Authors: Campbell Sabrina , Ahluwalia Monish , Desai Jamsheed , Khosravani Houman , Mitchell Sara B , Kassardjian Charles D 
Published: November 2024

Background and objectives: Current virtual care guidance lacks specialty-specific considerations. Neurological care is unique due to its reliance on physical examination and complex patient population. Our aim was to determine which factors impact virtual care suitability in neurology, virtual care adoption patterns, and satisfaction with virtual care among neurologists. Methods: Surveys were sent to Ontario neurologists through a shared email from September to November 2021. The survey consisted of four parts: demographics, virtual care adoption patterns, factors influencing virtual care use, and physician satisfaction with virtual care. Results: Sixty-six of 380 (17.4%) neurologists completed the survey. The pandemic resulted in a substantial increase in virtual care use, from 1.6% of all ambulatory visits in 2019 to 70.6% in 2020. Video teleconferencing was considered more appropriate across a broader range of presentations than phone visits, with both methods more suited to follow-ups. Neurologists were largely satisfied with virtual care except for the virtual neurological examination. The neurological presentations identified as least amenable to virtual consultation were movement disorders, limb weakness, gait/balance changes, and vision changes. Four presentations were felt to be most amenable to virtual care: sleep disorders, seizure, headache, and dizziness/syncope. Factors that were felt to reduce virtual care suitability included discussion of sensitive topics and acute presentations. Conclusion: Neurologists were satisfied with virtual care as a means of providing outpatient care, though the specific reason for referral influenced perceived appropriateness. These results can inform the basis of the development of consensus guidelines for virtual care provision in neurology.
Are Fiscal Transfers and Bail-Outs the Perpetrators? A Study on Moral Hazard Problem in Indian Federal Finance
Authors: Bora Nitu Moni , Barua Nissar A. 
Published: November 2024

The informational advantage of the sub-national governments in conjunction with central government’s involvement in bail-outs and financial assistance sometimes leads to negative incentives by relaxing the budget constraint. This produces moral hazard in terms of compromised fiscal behaviour; lower revenue effort, extravagance in expenditure, higher deficits and increased borrowings. At the same time, central assistance to low-performing states demotivates fiscally efficient states. The Indian fiscal federal structure and the fiscal transfer system are often criticized for prompting inefficiency and moral hazard in sub-national fiscal performance. Considering the issue of fiscal inefficiency in the Indian states, this study seeks to explore the fiscal mechanism of revenue effort, deficit, borrowing, capital outlay and revenue expenditure using a panel dataset of 28 states for the period 2000–2019. Accounting for the geographical and other disadvantages of the states, the findings of the panel-regression analysis confirm fiscal distress and the existence of soft-budget constraint and moral hazard in the Indian states. JEL Classification: H, H2, H21, H3, H7
Mineralogy and petrology of the petalite-subtype Prof pegmatite, Revelstoke, British Columbia, Canada
Authors: Breasley Catriona M. , Groat Lee A. , Martins Tânia , Linnen Robert L. , Larson Kyle P. , Henry Rhiana E. 
Published: November 2024

Abstract
The Prof pegmatite is located NW of Revelstoke, British Columbia, Canada on Boulder Mountain. Due to the abundance of petalite, the pegmatite is classified as a petalite subtype Li-Cs-Ta pegmatite or a Group one pegmatite. The Prof pegmatite contains a suite of minerals indicative of a highly evolved pegmatite melt including petalite, elbaite, lepidolite and Nb–Ta oxides. Four textural zones are present: (1) border; (2) intermediate, including (2.1) graphic texture dominant and (2.2) overgrowth dominant, where diverse minerals form rims around one another; (3) central; and (4) quartz. The border zone has a similar mineralogy to the intermediate zone and is interpreted to represent a chilled margin. The intermediate zone has a feldspar, mica, garnet and dravite–schorl dominant composition. The central zone hosts an evolved pegmatite core, which contains the majority of the lithium mineralisation composed of petalite, elbaite and lepidolite. The tourmaline, Nb–Ta oxides and mica within the pegmatite record the geochemical evolution of the melt from more primitive Fe- and Mg-rich minerals to a Li-, Mn- and Nb-rich assemblage indicative of a highly evolved geochemical system. The various pegmatitic textures and extremely fractionated geochemical composition of the pegmatite indicate that the melt was undercooled and crystallised rapidly. Three phases of metasomatism are recognised in the Prof pegmatite: an albitisation event observed cutting primary orthoclase; followed by a transition to a Na–Li–F-rich event mostly containing secondary albite, trilithionite and elbaites; and a sericitisation event.
The Prof pegmatite has a similar mineralogy to known pegmatites at Mount Begbie, 15 km to the south, in particular the notable presence of the rare mineral qitianlingite, petalite, lepidolite and elbaite. Together, these pegmatite bodies form part of an extensive, poorly mapped pegmatite field. Additional work is required to assess the extent and nature of mineralisation within this field.
The therapeutic potential of Apigenin in amyotrophic lateral sclerosis through ALDH1A2/Nrf2/ARE signaling
Authors: Liang Huiting , Zhou Xinhui , Zhang Jie , Xu Wenyuan , Liu Yi , Wang Xinxin , Hu Yushu , Xu Renshi , Li Xiaobing 
Published: November 2024

Abstract
Background
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron loss leading to muscle weakness and atrophy. Apigenin (APG), known for its antioxidant properties, holds potential as a therapeutic compound in ALS.

Methods
We used the Tg(SOD1*G93A)1Gur/J transgenic mouse model of ALS to investigate the therapeutic effects of APG. Key measured included motor function via the ALSTDI score, molecular markers of oxidative stress (OS) and apoptosis in spinal cord tissues. Techniques used included pathological, Western blotting, flow cytometry, and qRT-PCR to assess the effect of ALDH1A2.

Results
APG treatment attenuated weight loss and improved motor function scores in ALS mice compared to untreated ALS models. Molecular analyses revealed a significant upregulation of ALDH1A2 in APG-treated groups, along with a reduction in markers of OS and apoptosis. In vitro studies in NSC34 cells further confirmed the protective effects of APG against SOD1*G93A mutation-induced cytotoxicity. In addition, suppression of ALDH1A2 by shRNA exacerbated disease markers that were ameliorated by APG treatment.

Conclusions
Our results suggest that APG attenuates the progression of ALS pathology by regulating OS and apoptosis through ALDH1A2. These results support further investigation of APG as a potential therapeutic agent for the treatment of ALS.

Graphical Abstract
Regulatory T cells require peripheral CCL2-CCR2 signaling to facilitate the resolution of medication overuse headache-related behavioral sensitization
Authors: Ryu Sun , Zhang Jintao , Simoes Roli , Liu Xuemei , Guo Zhaohua , Feng Li , Unsinger Jacqueline , Hotchkiss Richard S. , Cao Yu-Qing 
Published: November 2024

Abstract
Background
Medication overuse headache (MOH) is the most common secondary headache disorder, resulting from chronic and excessive use of medication to treat headaches, for example, sumatriptan. In a recent study, we have shown that the peripheral C-C motif ligand 2 (CCL2), C-C motif chemokine receptor 2 (CCR2) and calcitonin-gene-related peptide (CGRP) signaling pathways interact with each other and play critical roles in the development of chronic migraine-related behavioral and cellular sensitization. In the present study, we investigated whether CCL2-CCR2 and CGRP signaling pathways play a role in the development of sumatriptan overuse-induced sensitization, and whether they are involved in its resolution by the low-dose interleukin-2 (LD-IL-2) treatment.

Methods
Mice received daily sumatriptan administration for 12 days. MOH-related behavioral sensitization was assessed by measuring changes of periorbital mechanical thresholds for 3 weeks. CCL2-CCR2 and CGRP signaling pathways were inhibited by targeted gene deletion or with an anti-CCL2 antibody. Ca2+-imaging was used to examine whether repetitive sumatriptan treatment enhances CGRP and pituitary adenylate cyclase–activating polypeptide (PACAP) signaling in trigeminal ganglion (TG) neurons. LD-IL-2 treatment was initiated after the establishment of sumatriptan-induced sensitization. Immunohistochemistry and flow cytometry analyses were used to examine whether CCL2-CCR2 signaling controls regulatory T (Treg) cell proliferation and/or trafficking.

Results
CCL2, CCR2 and CGRPα global KO mice exhibited robust sumatriptan-induced behavioral sensitization comparable to wild-type controls. Antibody neutralization of peripheral CCL2 did not affect sumatriptan-induced behaviors either. Repeated sumatriptan administration did not enhance the strength of CGRP or PACAP signaling in TG neurons. Nevertheless, LD-IL-2 treatment, which facilitated the resolution of sumatriptan-induced sensitization in wild-type and CGRPα KO mice, was completely ineffective in mice with compromised CCL2-CCR2 signaling. In CCL2 KO mice, we observed normal LD-IL-2-induced Treg expansion in peripheral blood, but the increase of Treg cells in dura and TG tissues was significantly reduced in LD-IL-2-treated CCL2 KO mice relative to wild-type controls.

Conclusions
These results indicate that the endogenous CCL2-CCR2 and CGRP signaling pathways are not involved in sumatriptan-induced behavioral sensitization, suggesting that distinct molecular mechanisms underlie chronic migraine and MOH. On the other hand, peripheral CCL2-CCR2 signaling is required for LD-IL-2 to reverse chronic headache-related sensitization.

Graphical abstract