bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative Pressure Ulcers After Geriatric Hip Fracture Surgery Are Predicted by Defined Preoperative Comorbidities and Postoperative Complications
Authors: Galivanche Anoop R. , Kebaish Kareem J. , Adrados Murillo , Ottesen Taylor D. , Varthi Arya G. , Rubin Lee E. , Grauer Jonathan N. 
Published: September 2019

Introduction:
The current study sought to determine the factors predictive of postoperative pressure ulcer development by analyzing extensive multicenter outcomes data from the 2016 American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database.

Methods:
The 2016 NSQIP Participant Use File and Hip Fracture Procedure Targeted file were used to identify the risk factors for the development of postoperative pressure ulcers after hip fracture surgery in a geriatric cohort. Multivariate regressions were performed to identify preoperative comorbidities and postoperative complications that are risk factors for developing postoperative pressure ulcers.

Results:
Of 8,871 geriatric hip fracture patients included in the study cohort, 457 (5.15%) developed pressure ulcers. Multivariate regressions identified the following preoperative risk factors for developing a postoperative pressure ulcer (in order of decreasing relative risk): preoperative sepsis, elevated platelet count, insulin-dependent diabetes, and preexisting pressure ulcer. Multivariate regressions also identified the following postoperative complications as risk factors for developing a postoperative pressure ulcer: postoperative sepsis, postoperative pneumonia, urinary tract infection, and postoperative delirium.

Discussion:
The identified preoperative factors and postoperative complications should help guide quality improvement programs.
Long-term urinary functional outcome of vesicourethral anastomosis with bidirectional poliglecaprone (Monocryl®) vs. barbed polyglyconate suture (V-LocTM 180) in robot-assisted radical prostatectomy
Authors: Rajih Emad , Meskawi Malek , Alenizi Abdullah M. , Zorn Kevin C. , Alnazari Mansour , Borhan Walaa , Zanaty Marc , El-Hakim Assaad 
Published: September 2019

Introduction: We aimed to evaluate urinary continence recovery following robot-assisted radical prostatectomy (RARP) using monofilament poliglecaprone (Monocryl®) suture vs. barbed suture (V-LocTM 180) during vesicourethral anastomosis.
Methods: In this prospective, observational cohort, data were collected on 322 consecutive patients. All patients underwent continuous, bidirectional, single-layer running anastomosis with either 3.0-monofilament suture (n=141) or 3.0 barbed suture (n=181). The primary outcome was continence recovery defined as time to 0 pad at one, three, six, 12, and 24 months following surgery.
Results: Continence rates were significantly better with monofilament VUA at all followup time points up to one year. Median time to continence was one month vs. five months in the monofilament group vs. barbed group, respectively (p<0.001). Continence rates in monofilament suture vs. barbed group at one, three, six, 12, and 24 months were 56% vs. 26% (p<0.001), 73% vs. 36.4% (p<0.001), 84.4% vs. 60.2% (p<0.001), 90.8% vs. 71.9% (p<0.001), and 93.5% vs.87.1% (p=0.1), respectively. Anastomosis time was shorter in the barbed group, with a median of 23 vs. 30 utes (p<0.001). Patients anastomosed with Monocryl suture had smaller prostate weight (median 42.5 g vs. 50 g; p<0.001) and harbored less advanced disease (T2a‒c 76.6 vs. 74%; p=0.01) relative to patients treated with V-Loc 180 suture. However, in a multivariate Cox logistic regression analyses, independent predictors of continence recovery were suture type (hazard ratio [HR] 53; 95% confidence interval [CI] 0.41‒0.68; p=0.02] and prostate size (HR 0.99; 95% CI 0.98‒0.99; p<0.001).
Conclusions: Barbed VUA contributed to delayed continence recovery compared to monofilament poliglecaprone suture during the first year post-RARP. However, no statistically significant difference was recorded at two years post-RARP. These results warrant special attention, especially with the widespread use of barbed suture in recent years.
Présentation
Authors: Van de Velde Cécile 
Published: September 2019

Cet article retrace les étapes qui marquent la construction de l’objet « solitude » en sociologie. Il montre comment la solitude a d’abord été appréhendée comme une conséquence néfaste de la modernité et assimilée à un défaut d’intégration sociale, puis saisie par le prisme de deux figures fondatrices, le « mourant » et la « femme seule ». Il revient ensuite sur les paradigmes successifs qui ont marqué la construction de ce champ à partir des années 1990 — « vivre seul », « être seul », « se sentir seul » — et explore quelques-uns de ses fronts de recherche contemporains, tels que les solitudes juvéniles, le rôle des réseaux sociaux, et les différenciations de genre. Il invite enfin à une désegmentation de ce champ, et met en dialogue plusieurs formes de solitudes — intimes, familiales, sociales —, pour réinscrire cette expérience dans la dynamique de nos liens tout au long de la vie.
Le congé parental : une traversée en solitaire ?
Authors: Chatot Myriam 
Published: September 2019

Cet article explore les fondements du sentiment de solitude exprimé par la majorité des parents en congé parental. L’analyse des discours des parents, recueillis dans le cadre d’entretiens semi-directifs, met en évidence l’intériorisation d’un modèle de « disponibilité permanente » à l’enfant pendant le congé, qui induit l’isolement et le sentiment de solitude du parent en congé. Ce modèle limite la possibilité de ce dernier de prendre du temps pour lui ou de maintenir ses relations sociales à l’extérieur du foyer. Intériorisée par les mères davantage que par les pères, l’exigence de se dévouer aux enfants et au foyer conduit à ce que le rôle statutaire de parent en congé prenne le pas sur l’identité personnelle de l’individu, renforçant le sentiment de solitude. La reprise de l’activité professionnelle est alors attendue comme un moyen de ne plus être qu’un parent.
Rendre les solitudes supportables
Authors: Bordiec Sylvain 
Published: September 2019

À partir d’une investigation menée dans un groupe d’entraide mutuelle (GEM) — institution destinée à faire pièce aux isolements des « malades psychiques » —, cet article étudie les relations entre d’un côté les « pratiquants » de solitude, pour qui cette pratique fait problème et les incline à lutter contre elle et, de l’autre côté, l’« espace des luttes publiques et parapubliques contre l’isolement ». L’étude de cette relation se veut éclairante sur les forces intégratrices et socialisatrices des institutions de cet espace. Pour ce faire, l’investigation examine d’abord les ressorts biographiques des isolements de ces « isolés » et ce que la vie a fait d’eux avant leur entrée au GEM. Ensuite, l’observation et l’écoute de ces « isolés » montrent comment peuvent interagir luttes individuelles et luttes collectives contre les solitudes. À défaut de (re)socialiser les individus de telle sorte que leurs pratiques du monde social cessent définitivement de les conduire vers des solitudes honnies, ces interactions offrent aux « isolés » des formes d’intégration sociale leur étant ailleurs inaccessibles. Révélatrices des pouvoirs inégaux des institutions à former et à transformer les individus, ces luttes sont moins les génératrices de dispositions nouvelles autorisant une « vie normale » que les garantes du maintien en éveil d’une disposition de vie, fût-ce cette existence en décalage avec les normes dominantes.
Long-term studies reveal major environmental factors driving zooplankton dynamics and periodicities in the Black Sea coastal zooplankton
Authors: Vereshchaka Alexander L. , Anokhina Liudmila L. , Lukasheva Taisiya A. , Lunina Anastasiia A. 
Published: September 2019

Background
The development and management of shelf-sea ecosystems require a holistic understanding of the factors that influence the zooplankton structure and ecosystem functions. The Black Sea is an example of such areas influenced by eutrophication, overfishing, climate variability, invasions of the ctenophores Mnemiopsis leidyi followed by Beroe ovata. Thus, there is a set of principal factors which may influence and explain periodicities in the Black Sea ecosystem.

Methods
We analysed a total of 918 samples taken from 1991 to 2017 with intervals of 10 days. Taxa were identified to species, their abundance and biomass were calculated. We tested 12 environmental factors, which may explain zooplankton distribution: temperature, productivity-linked factors (surface chlorophyll as a proxi), wind, turbidity, lowest winter temperature, and concentration of the ctenophore M. leidyi. We used canonical correspondence analyses to find the dominant environmental factors and further regression analyses to retrieve dependences of plankton biomass on the major factors. Periodicities were assessed with the use of the Continuous wavelet transform and tested with use of One-way ANOSIM and PERMANOVA. The distances between ecosystem states in different years were assessed using non-metric multidimensional scaling.

Results
Currently, temperature and productivity are the major environmental factors driving zooplankton dynamics. Not long ago, before 1999, abundance of M. leidyi was one of the major factors explaining the zooplankton variance. Spectral analysis of species abundances revealed a 4-year transitional period in 1999–2002 (not reported before) when ecosystem adapted to a new invader B. ovata. Statistically robust 2- and 3-year periodicities were retrieved for most plankton taxa and some benthic larvae. We found robust correlations between temperature and surface chlorophyll concentration on one side and plankton abundances and biomass on the other, and retrieved multivariate regressions, which may have a prognostic value.
Influence of Environmental Heterogeneity on the Species Composition, Species Richness and Species Abundances Unevenness in Reef-associated Conus Communities (Neogastropoda) from Papua New-Guinea
Authors: Béguinot Jean 
Published: September 2019

To what extent differences in species composition, species richness and species abundance unevenness between marine communities are attributable to heterogeneities of the surrounding environment and/or to inter-community distance is a fundamental issue to be addressed, in order to more deeply understand the functioning of marine ecosystems. A comparison between six reef-associated Conus communities, differing more or less in both their surrounding environment and their mutual geographical distance, offers a relevant opportunity to address these questions.
As expected, environmental heterogeneities prove having a significant influence on the dissimilarity in species composition, whereas distance-decay in similarity reveals comparatively negligible, at least within the investigated range of distances, up to 60 km. Less expectedly, more homogeneous surrounding environments between communities tend, here, to increase the dissimilarity in species richness. At last, here, difference in species abundance unevenness between communities seems unrelated to either environmental heterogeneity or inter-community distance.
From a methodological point of view, these results could not have been reliably established without the prior implementation of a least-biased procedure of numerical extrapolation applied to the available incomplete samplings. Also, the relevant assessment of dissimilarity in species composition required using a modified Jaccard index, rendered insensitive to bias-induced differences in communities species richness.
Nutraceutical Potential and Antipsychotic Activity of Local Dry Fruit Waste – Juglans regia
Authors: Jadhav Rachna Shashikant , Palamthodi Shanooba , Saha Bhaskar 
Published: September 2019

Aim: To identify the biologically active components in shells of Juglans regia and study its nutraceutical potential and antipsychotic activity for effective waste management.
Study Design: Biochemical and in vivo analyses of plant extract using established protocols.
Place and Duration of Study: Sample extraction at Department of Food Science and technology, School of Biotechnology and Bioinformatics, DY Patil deemed to be University, Navi Mumbai, India; sample components identification at Sophisticated Analytical Instrument facility (SAIF), Indian Institute of Technology (IIT), Mumbai, India; and in vivo studies for antipsychotic activity using Caenorhabditis elegans at Department of Life Science and Biochemistry, St. Xavier’s College, Mumbai, India between November 2018 and May 2019.
Methodology: The shells of Juglans regia were milled and the extract was prepared using Soxhlet extraction at 60oC using methanol as solvent. The GCMS analysis of the extract was carried out using a GC JEOL – The Accu TOF. Antipsychotic activity was studied using pharyngeal pumping assay in Caenorhabditis elegans.
Results: GC-MS analysis of methanolic extract of shells of Juglans regia revealed the presence of Tridecanoic acid, Acetoxyacetic acid, nonyl ester, 2-hexenal, 2-ethyl, Eicosanoic acid, phenylmethyl ester, Undecane, Benzeneacetic acid decyl ester, (1-pentyl-allyoxymethoxy-methyl)-benzene), 9,12-octadecadienoic acid(Z,Z), phenylmethyl ester, Benzyl oxytridecanoic acid, 6,9,12- octadecatrienoic acid, phenylmethyl ester (Z,Z), 9- octadecanoic acid (Z), phenylmethyl ester, 9,12,15- octadecatrienoic acid, Z [(trimethyl (sil)oxy, 1 – trimethyl (sily)oxy] ethyl ester (Z,Z,Z). Furthermore, behavioural assay done using Caenorhabditis elegans as a model organism showed that the sample exerted antipsychotic activity at lowest concentration.
Conclusion: The shells of Juglans regia being a natural source, can be used as an alternative to the synthetic antipsychotic drugs that have side effects. Our current work suggests that the walnut shells that end up into trash bins are an excellent source of effective natural biologically active compounds.
Trend of Wearing Personal Protective Equipment by Dentists in Karachi, Pakistan
Authors: Ahmed Hina 
Published: September 2019

Objectives: To investigate the trend of wearing personal protective equipment by dentists in Karachi, Pakistan.
Methodology: Study was conducted over a period of three months in Karachi. Study included dentists working in Dental practices. Dental students and dentists not registered with Pakistan Medical and Dental Council were excluded from the study. The total filled questionnaires obtained were 251. Data analysis as done on SPSS version 20.0 and chi square test was used to assess difference amongst dentists.
Results: The trend of wearing personal protective equipment such as gloves, mask and protective eye wear showed statistically significant differences amongst dentists. More over disposal of sharp objects and disinfection of surfaces between patients also significantly varied amongst dentists working in different places.
Conclusions: Dentists working in different work places showed great variation in wearing personal protective equipment during dental procedures.
Monitoring Strategy of Chrome Electroplating Workers’ Health at Company XYZ
Authors: Suhendi Daben , . Kholil , Sulistyadi Kohar 
Published: September 2019

Consequetly, one million deaths from 14% of fatality due to occupational accidents caused harmful substances in the year 2015; therefore, it increases of more than 90000 workers when compared to 2011. Company XYZ with workers about 2500 people is a company that provides special electroplating (chrome plating) service to repair vessels within industry.
This study aims to recommend a strong policy that can be applied to monitor chrome plating workers’ health in Company XYZ. The method used in this study is a qualitative approach with analysis methods, strategic assumption surfacing and testing (SAST) and to obtain decisions about recommendations to be taken using the exponential comparison method (ECM). The results shows that the level of exposure of chromium on workers in company XYZ was at high risk level, which may affected worker’ health, 2 of 13 workers have a rate of chromium in blood 1.11ug/L and 1.10ug/L. Therefore the expert recommendation of the medical surveillance program for this research study; that all workers are required to do periodic medical assessment every 6 months, and the medical assessment for worker prior joining in the chrome plating project is must. In addition, focused medical assessment will include complete blood count, liver function, renal function, chromium serum in blood and urine, spirometry, chest x-ray, integument and respiratory system. Deep interview on medical and occupational history, such as the presence of chromium exposure in the past, current and anticipated future exposures are also required to support the data for evaluation purpose. The ability to use respirators assessment considers as additional assessment to protect the workers accordingly. The health practitioner will summarize all medical reports, discuss and provide recommendation to employee as well as to the employer.
Health status of workers approximately 60 years of age and the risk of early death after compulsory retirement: A cohort study
Authors: Sakurai Masaru , Ishizaki Masao , Miura Katsuyuki , Nakashima Motoko , Morikawa Yuko , Kido Teruhiko , Naruse Yuchi , Nogawa Kazuhiro , Suwazono Yasushi , Nogawa Koji , Nakagawa Hideaki 
Published: September 2019

Abstract

Objectives
The increasing number of working elderly people has enhanced the importance of workplace health promotion activities. We investigated the association between the health status of workers approximately 60 years of age and the risk of all-cause mortality after compulsory retirement in Japan.

Methods
The 2026 participants (1299 males and 727 females) had retired from a metal-products factory at ≥60 years of age. Baseline health examinations were conducted at 60 years of age and included questions about medical history and lifestyle factors; the participants also underwent a physical examination. The participants were followed up annually by mail for an average of 7.4 years. The association between health status at age 60 years and the risk of all-cause mortality was assessed by Cox proportional hazards regression analysis.

Results
During the study, 71 deaths were reported. The age- and sex-adjusted hazard ratio (HR [95% confidence interval]) for all-cause mortality was higher for males (HR, 3.41 [1.73-6.69]) compared with females, participants with a low body mass index (&lt;18.5 kg/m2; HR 3.84 [1.91-7.73]) compared with normal body weight, smokers (HR, 2.63 [1.51-4.58]) compared with nonsmokers, and those with three or more of four metabolic abnormalities (obesity, high blood pressure, dyslipidemia, and glucose intolerance) (HR 2.29 [1.04-5.02]) compared with no metabolic abnormalities. The associations were unaffected by adjustment for these factors.

Conclusion
Maintenance of an appropriate body weight, smoking cessation, and elimination of metabolic syndrome are required for older workers to prevent early death after retirement.
Altered long noncoding RNA profile after intracerebral hemorrhage
Authors: Kim Jeong‐Min , Moon Jangsup , Yu Jung‐Suk , Park Dong‐Kyu , Lee Soon‐Tae , Jung Keun‐Hwa , Chu Kon 
Published: September 2019

AbstractObjectiveWe investigated the expression pattern of long noncoding RNAs (lncRNA) and messenger RNAs (mRNA) from two different intracerebral hemorrhage (ICH) rat models, and performed gene ontology and gene/protein interaction analyses.MethodsWe harvested hemorrhagic brain 1, 3, and 7 days after ICH induction by stereotactic collagenase injection. We performed microarray analyses with Agilent array platform to compare the expression of lncRNA and mRNAs from hemorrhagic and normal brains. The RNA expression patterns were also examined from the autologous blood injection ICH model at days 1 and 3, and significantly altered lncRNAs from two ICH models were validated by quantitative reverse transcriptase‐polymerase chain reaction. Gene ontology analysis and pathway analysis were performed with differentially expressed mRNAs after ICH. Gene and protein interaction analysis was performed to elucidate the functional role of upregulated lncRNA in neuronal damage.ResultsAmong the 13,661 lncRNAs studied, 83, 289, and 401 lncRNAs were significantly elevated after 1, 3, and 7 days after collagenase‐induced ICH, respectively. NR_027324, or H19, was the most upregulated lncRNA after 1 day from the two ICH models and its elevation persisted until the 7th day. Gene ontology analysis revealed that immune‐related biological processes such as immune response, immune system process, and defense response were upregulated from both ICH models. Gene and protein interaction study demonstrated that NR_027324 was closely related to the type I interferon signaling pathway.InterpretationThis study illustrates the dynamic expression pattern of the lncRNA profile following ICH, and that H19 is the most consistently upregulated lncRNA after ICH.
Motor neuron diseases caused by a novel VRK1 variant – A genotype/phenotype study
Authors: Sedghi Maryam , Moslemi Ali‐Reza , Olive Montse , Etemadifar Masoud , Ansari Behnaz , Nasiri Jafar , Emrahi Leila , Mianesaz Hamid‐Reza , Laing Nigel G. , Tajsharghi Homa 
Published: September 2019

AbstractBackgroundMotor neuron disorders involving upper and lower neurons are a genetically and clinically heterogenous group of rare neuromuscular disorders with overlap among spinal muscular atrophies (SMAs) and amyotrophic lateral sclerosis (ALS). Classical SMA caused by recessive mutations in SMN1 is one of the most common genetic causes of mortality in infants. It is characterized by degeneration of anterior horn cells in the spinal cord, leading to progressive muscle weakness and atrophy. Non‐SMN1‐related spinal muscular atrophies are caused by variants in a number of genes, including VRK1, encoding the vaccinia‐related kinase 1 (VRK1). VRK1 variants have been segregated with motor neuron diseases including SMA phenotypes or hereditary complex motor and sensory axonal neuropathy (HMSN), with or without pontocerebellar hypoplasia or microcephaly.ResultsHere, we report an association of a novel homozygous splice variant in VRK1 (c.1159 + 1G>A) with childhood‐onset SMA or juvenile lower motor disease with brisk tendon reflexes without pontocerebellar hypoplasia and normal intellectual ability in a family with five affected individuals. We show that the VRK1 splice variant in patients causes decreased splicing efficiency and a mRNA frameshift that escapes the nonsense‐mediated decay machinery and results in a premature termination codon.ConclusionsOur findings unveil the impact of the variant on the VRK1 transcript and further support the implication of VRK1 in the pathogenesis of lower motor neuron diseases.