bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vieillissement et territoires : cadres théoriques et enjeux empiriques
Authors: Blanchet Mickaël , Pihet Christian , Chapon Pierre-Marie 
Published: June 2019

Du latin territorium , le territoire désigne selon Guy Di Méo (1998) « une appropriation à la fois économique, idéologique et politique (sociale, donc) de l’espace par des groupes qui se donnent une représentation particulière d’eux-mêmes, de leur histoire » (Di Méo, 1998, p. 42). Édifice matériel et idéel, le territoire ne fonctionne pas comme un support neutre et univoque et varie selon différents processus d’appropriation. Dans un contexte de vieillissement de la population, géographiquement différencié, et de politiques gérontologiques sectorisées et individualisées, le territoire s’est progressivement imposé comme un moyen de compréhension des problématiques gérontologiques et un levier d’action sur le plan politique. Aujourd’hui, l’intérêt pour la notion de « territoire » est visible au sein de la gérontologie, à travers des programmes mondiaux comme celui de l’Organisation mondiale de la santé (OMS) en faveur des « villes et communautés-amies des aînés » (Vada) ou dans la loi relative à l’adaptation de la société au vieillissement (décembre 2015). Fort de cette orientation, l’objectif de l’article consiste à présenter la force du concept de « territoire » dans l’appréhension des dynamiques gérontologiques, notamment en montrant en quoi une approche systémique de cette notion s’avère propice à la compréhension des processus de production, d’organisation, d’inclusion et d’exclusion dans le domaine gérontologique.
Vieillir chez soi dans la diversité des formes urbaines et rurales du Québec, Canada
Authors: Lord Sébastien , Negron-Poblete Paula , Després Michel 
Published: June 2019

Dans le cadre de la démarche « Municipalités-amies des aînés » (Mada), les municipalités québécoises sont appelées à développer une réflexion, avec un protocole d’évaluation commun, visant la mise en place d’aménagements et services qui permettraient un vieillissement plus inclusif et actif. Dans ce contexte, si la mobilité est fortement tributaire des caractéristiques individuelles, les attributs du territoire ont aussi une incidence sur le potentiel de mobilité de ses habitants et sur leurs possibilités de participation sociale. Ainsi, la relative mixité fonctionnelle, la densité résidentielle et l’accessibilité territoriale des quartiers centraux des grandes villes sont souvent présentées comme plus favorables au vieillissement que les milieux suburbains. Mais qu’en est-il des villes moyennes, des territoires périurbains, ou des zones rurales ? Est-ce que l’on serait en présence d’enjeux d’aménagement significativement différents, voire contrastés, qui nécessiteraient une démarche Mada particulière ? Dans cet article nous nous penchons sur le rôle que jouent l’aménagement et l’urbanisme dans la construction et la consolidation de territoires favorables au vieillissement selon différents milieux de vie. D’abord, nous proposons une typologie de formes résidentielles déclinée dans six régions québécoises (Outaouais, Laurentides, Lanaudière, Montréal, Laval et Mauricie) faisant ressortir des enjeux communs, mais souvent contrastés. Ensuite, nous débattons de ces enjeux à la lumière de huit groupes de discussion menés avec des aînés de ces territoires. Si la complexité des enjeux apparaît déterminante, leur dénominateur commun qu’est le couple proximité/accessibilité ressort comme un objet de réflexion et d’intervention multidisciplinaire privilégié et fondamental.
Exclure et protéger
Authors: Perrin-Joly Constance 
Published: June 2019

À partir d’une enquête ethnographique dans une grande entreprise de transport française, cet article propose d’identifier les processus de ségrégation ou d’éviction des salariés, selon leur âge ou leur genre, tout au long de leur parcours professionnel. La culture virile, propre aux métiers du transport, rend difficile la prise en considération de la pénibilité du travail par son organisation même, justifiant ainsi l’exclusion des femmes et des plus âgés considérés comme potentiellement moins aptes à la supporter. Pourtant certaines femmes peuvent à terme être intégrées, à condition de se soumettre à la norme professionnelle et organisationnelle très stricte de la « maternité contrôlée ». Elles bénéficieront alors, au même titre que les salariés masculins les plus âgés, de la solidarité du collectif, d’autant plus puissante que le groupe professionnel est reconnu. Cette solidarité permet à certains d’entre eux (hommes et femmes) de supporter la pénibilité et de se maintenir dans le métier en dépit de l’avancée en âge.
Métiers d’art itinérants : artisans en migration (France et espace alpin, xviie-xixe siècle)
Authors: Duhem Sophie 
Published: June 2019

La finalité de ce dossier thématique est de comprendre, dans un contexte de migration, la nature des dynamiques sociales à l’œuvre en milieu urbain et rural autour des métiers d’art itinérants ou exercés par des artisans émigrés, des Italiens notamment. La chronologie envisagée englobe l’époque moderne – car si la présence italienne en France à la Renaissance a été largement documentée par la bibliographie, les xviie et xviiie siècles le sont beaucoup moins, comme la première moitié du xixe siècle, marquée par l’arrivée et l’installation de nombreux artisans émigrés. Cette introduction examine plusieurs points : après une brève présentation de l’objet d’étude et un état des lieux non exhaustif de la bibliographie, elle veut s’attacher aux cadres de la réflexion actuelle, en partant de l’analyse des réseaux sociaux, de l’étude des transferts culturels et d’approches convergentes. Nous discuterons l’intérêt de ces nouveaux outils comme les apports complémentaires des méthodologies utilisées par les auteurs de ce numéro pour saisir les relations interpersonnelles au sein des communautés formées par les artisans émigrés.
Les Italiens dans le Val de Saône. Découverte d’un réseau d’artisans émigrés au xviiie et au xixe siècle
Authors: Guéritey Pierre Marie 
Published: June 2019

Entre 1760 et 1870, les stucateurs, plâtriers et entrepreneurs italiens de la Valsesia sont la seule population d’étrangers présente dans le Val de Saône, structurée par ses liens familiaux et la relation conservée avec ses villages d’origine, ouverte au milieu d’accueil par la communauté de techniques. Les décors qu’ils réalisent à la veille de la Révolution, en particulier dans les églises, sont déjà néoclassiques. Les sources permettent d’identifier ces œuvres et documentent presque au quotidien la vie de plusieurs générations de ces artisans.
L’étude de l’histoire de l’art au Québec et au Canada, du xviie au xixe siècle, à l’aune des échanges culturels et des interrelations sociales
Authors: Ouellet Pierre-Olivier 
Published: June 2019

Dans le contexte d’un entretien mené par Sophie Duhem et articulé autour des questions de circulations, de réseaux sociaux, de transferts culturels et d’« identités artistiques », cet article effectue un retour sur les cadres méthodologiques et théoriques utilisés par l’historien de l’art Pierre-Olivier Ouellet lors de ses recherches menées sur les arts québécois et canadien. Celui-ci prend notamment appui sur sa thèse de doctorat, Circulation, usages et fonctions des œuvres d’art par les civils et les militaires en Nouvelle-France (1608-1759), ses divers articles, de même que sur ses recherches actuelles sur l’artiste canadien-français François Baillairgé (1759-1830) afin de mieux définir son cheminement et développer des réflexions autour de sa pratique et de son champ d’étude.
Une migration sous le regard d’Alphonse Dupront
Authors: Teulières Laure 
Published: June 2019

L’article constitue un accompagnement critique de l’étude intitulée « L’immigration italienne dans le Gers », rédigée en 1928 par Alphonse Dupront et restée inédite jusqu’à sa publication en 2018. Écrit de jeunesse du futur grand historien, alors étudiant normalien, elle aborde l’immigration à travers l’enquête de terrain qu’il a réalisée dans sa région d’origine (le canton de Condom). L’approche est caractérisée par cet ancrage territorial, cette proximité à l’objet et ce choix méthodologique. Alphonse Dupront pose un regard ancré dans la géographie physique du milieu rural gascon, mobilise les catégories de son temps tout en développant une approche compréhensive du sujet. Loin des débats inquiets sur les migrations et des théorisations abusives qui entachent bien des textes de cette époque, son étude constitue un jalon tout à fait remarquable au vu de l’historiographie à venir.
Quantifying Lygus (Hemiptera: Miridae) damage in faba bean (Fabaceae) seeds using shortwave-infrared imaging
Authors: Smith A.M. , Rivard B. , Feng J. , Carcamo H.A. 
Published: June 2019

AbstractLygus Hahn (Hemiptera: Miridae) feeding in faba beans (Vicia faba Linnaeus (Fabaceae)) often results in a reduction in seed quality and economic losses. Traditionally, seed damage is assessed subjectively through visual examination by a trained individual, but the use of non-destructive imaging to evaluate seed quality is gaining momentum. The focus of this study was to determine the ability to quantify Lygus species damage in faba bean using shortwave-infrared imaging and two analysis techniques: (1) spectral angle mapper and (2) simple reflectance indices. Seed samples were visually assessed for damage before imaging in 242 wavebands between 980 and 2500 nm. Four spectral intervals, involving 102 wavebands, were identified as optimal for the detection of seed damage using spectral angle mapper. A strong relationship was obtained between the area of seed damage derived using spectral angle mapper and visually (R2 = 0.95). Seed damage derived by thresholding of two normalised faba bean damage indices involving reflectance at 1086 and 1313 nm and 2218 and 2342 nm also showed a strong relationship with the visual assessment (R2 = 0.92). The two image analysis techniques provided similar results. The study suggests that imaging in the shortwave-infrared wavelengths and the derivation of simple indices can effectively quantify faba bean damage by Lygus feeding.
MET Receptor Amplification Drives Resistance to Anti-EGFR Therapies
Authors: Romano Patricia Martin , Castanon Eduardo , Hollebecque Antoine , Lacroix Ludovic , Auger Nathalie , Angevin Eric , Tselikas Lambros , Ammari Sami , Soria Jean-Charles , Massard Christophe 
Published: June 2019

Abstract
Mesenchymal–epithelial transition factor (MET) amplification has been suggested either as a de novo or acquired mechanism of resistance to anti-epidermal growth factor receptor (anti-EGFR) therapy. However, even if MET amplification has been widely described in the preclinical setting, only a few clinical data have confirmed the role of MET in the resistance to anti-EGFR treatment. A 60-year-old man presenting cholangiocarcinoma with EGFR amplification had a tumor response to anti-EGFR therapy. A new on-purpose tumor biopsy performed during tumor progression confirmed the known EGFR amplification as well as a new MET amplification. This clinical observation highlights the role of MET amplification as a mechanism of resistance to EGFR inhibitors.
The burden of urological disease in Zomba, Malawi: A needs assessment in a sub-Saharan tertiary care center
Authors: Juvet Tristan , Hayes James R. , Ferrara Sarah , Goche Duncan , Macmillan Robert D. , Singal Rajiv K. 
Published: June 2019

Introduction: A large part of the developing world continues to lack access to surgical care. Urology remains one of the least represented surgical subspecialties in global health. To begin understanding the burden of urological illness in sub-Saharan Africa, we sought to characterize all patients presenting to a tertiary care hospital in Malawi with a urological diagnosis or related complaint in the past year.
Methods: Retrospective review of the surgical clinic and surgical theater record books at Zomba Central Hospital (ZCH) was performed over a one-year time span. Patients presenting with urological diagnoses or undergoing a urological procedure under local or general anesthetic in the operating theater were identified and entered into a database.
Results: A total of 440 clinical patients were reviewed. The most common clinical presentations were for urinary retention (34.7%) and lower urinary tract symptoms (15.5%); 182 surgical cases were reviewed. The most common diagnoses for surgical patients were urethral stricture disease (22%), bladder masses (17%), and benign prostatic hyperplasia (BPH) symptoms (14.8%). Urethral stricture-related procedures, including direct visual internal urethrotomy and urethral dilatation were the most common (14.2% and 7.7%). BPH-related procedures, including simple prostatectomy and transurethral resection of the prostate were the second most common (6.7% and 8.2%).
Conclusions: Urethral stricture disease, BPH, and urinary retention represent the clinical diagnoses with the highest burden of visits. Despite these numbers, few definitive procedures are performed annually. Further focus on urological training in sub-Saharan Africa should focus on these conditions and their surgical management.
Preoperative follicle-stimulating hormone: A factor associated with semen parameter improvement after microscopic subinguinal varicocelectomy
Authors: Madhusoodanan Vinayak , Blachman-Braun Ruben , Patel Premal , Ji Lunan , Masterson Thomas A. , Owyong Michael , Greer Aubrey , Ramasamy Ranjith 
Published: June 2019

Introduction: Currently, there exists no serum biomarker to predict patients likely to benefit from varicocelectomy. The purpose of this study was to assess the association between baseline follicle-stimulating hormone (FSH) and semen parameter changes after subinguinal microscopic varicocelectomy.
Methods: We retrospectively reviewed all men who underwent microscopic subinguinal varicocelectomy between August 2015 and October 2018. Pre- and postoperative semen analyses were stratified per total motile sperm count (TMSC): TMSC <5, 5–9, and >9 million (based on TMSC required for in vitro fertilization, intrauterine insemination (IUI), and natural conception, respectively). Then, variables were analyzed to determine the correlation with postoperative TMSC values and upgrade in TMSC category.
Results: Among the 66 men analyzed, 55 (83.3%) and 11 (16.7%) had a preoperative TMSC of <5 million and 5–9 million, respectively. A total of 33 (50%) patients upgraded in TMSC category, 26 of them achieving levels corresponding to natural conception and seven achieving those of IUI. Additionally, a significant correlation was observed between postoperative TMSC and preoperative TMSC (r=0.528; p<0.001), and preoperative FSH (r=-0.314; p=0.010). A lower preoperative FSH (odds ratio [OR] 0.82; 95% confidence interval [CI] 0.68–0.98; p=0.028) and a higher preoperative TMSC (OR 1.37; 95% CI 1.06–1.76; p=0.015) were associated with upgrade in TMSC category.
Conclusions: Lower preoperative FSH and higher TMSC are associated with improvement in TMSC category after varicocelectomy, although small sample size limited the study. FSH can be useful to identify men who are most likely to benefit from varicocele repair.
A novel predictor of clinical progression in patients on active surveillance for prostate cancer
Authors: Tan Guan Hee , Finelli Antonio , Ahmad Ardalan , Wettstein Marian , Zlotta Alexandre , Fleshner Neil , Hamilton Robert J. , Kulkarni Girish , Ajib Khaled , Nason Gregory , Perlis Nathan 
Published: June 2019

Introduction: Active surveillance (AS) is standard of care in low-risk prostate cancer (PC). This study describes a novel total cancer location (TCLo) density metric and aims to determine its performance in predicting clinical progression (CP) and grade progression (GP).

Methods: This was a retrospective study of patients on AS after confirmatory biopsy (CBx). We excluded patients with Gleason ≥7 at CBx and <2 years follow-up. TCLo was the number of locations with positive cores at diagnosis (DBx) and CBx. TCLo density was TCLo / prostate volume (PV). CP was progression to any active treatment while GP occurred if Gleason ≥7 was identified on repeat biopsy or surgical pathology. Independent predictors of time to CP or GP were estimated with Cox regression. Kaplan-Meier analysis compared progression-free survival curves between TCLo density groups. Test characteristics of TCLo were explored with receiver operating characteristic (ROC) curves.

Results: We included 181 patients who had CBx between 2012-2015, and met inclusion criteria. The mean age of patients was 62.58 years (SD=7.13) and median follow-up was 60.9 months (IQR=23.4). A high TCLo density score (>0.05) was independently associated with time to CP (HR 4.70, 95% CI: 2.62-8.42, p<0.001), and GP (HR 3.85, 95% CI: 1.91-7.73, p<0.001). ROC curves showed TCLo density has greater area under the curve than number of positive cores at CBx in predicting progression.

Conclusion: TCLo density is able to stratify patients on AS for risk of CP and GP. With further validation, it could be added to the decision-making algorithm in AS for low-risk localized PC.
A busca por seu igual: As alianças étnicas da diáspora atlântica nos espaços do casamento católico na Paróquia do Pilar. (São João del-Rei, séculos XVIII e XIX):
Authors: Delfino Leonara Lacerda 
Published: June 2019

O artigo analisa o papel das estratégias matrimoniais como instrumento de fronteirização cultural na diáspora atlântica, buscado por estrangeiros para o fortalecimento de suas afinidades culturais construídas no contexto da pós-travessia. No primeiro momento, analisamos as imposições demográficas colocadas pela participação da Freguesia no tráfico de escravos, para, em seguida, investigarmos a confluência da distribuição étnica no processo de seletividade matrimonial produzido por estrangeiros e insiders (escravos nascidos no Brasil). Para este fim utilizamos as fontes seriais, como os assentos de óbitos e de casamentos alocados na Freguesia do Pilar de São João del-Rei (MG).Palavras-chave: diáspora atlântica, endogamia cultural, casamento escravo.
Resolving the synonymy and polyphyly of the ‘Drosophila bakoue species complex’ (Diptera: Drosophilidae: ‘D. montium species group’) with descriptions of two new species from Madagascar
Authors: Yassin Amir , Suwalski Arnaud , Raveloson Ravaomanarivo Lala H. 
Published: June 2019

The ‘D. bakoue species complex’ Rafael, 1984 (‘D. montium species group’ Da Lage et al., 2007) comprises seven Afrotropical species. Using complete mitochondrial genome sequences and detailed morphological analysis, we revised the phylogenetic relationships between these species including two new ones. We found the ‘D. bakoue species complex’ to be a junior synonym of the ‘D. seguyi species complex’ Lachaise, 1971 and its seven species polyphyletic. We thus classified the species into three complexes, the ‘D. seguyi species complex’ comprises D. seguyi Smart, 1945, D. malagassya Tsacas & Rafael, 1982, D. curta Chassagnard & Tsacas, 1997 and D. chocolata sp. nov., the new ‘D. tsacasi species complex’ comprises D. tsacasi Bock & Wheeler, 1972 and D. seguyiana Chassagnard & Tsacas, 1997, and the new ‘D. vulcana species complex’ comprises D. vulcana Graber, 1957 and D. mylenae sp. nov. Drosophila bakoue Tsacas & Lachaise, 1974 could not be assigned to any of the defined complexes. The two new species are endemic to Madagascar and we report the presence of D. seguyi and D. curta in Mayotte and Madagascar, respectively. The results hence represent a significant step towards understanding the diversity and evolution of this species group in Africa and the islands of the Western Indian Ocean.
Validation of a Next-Generation Sequencing Assay Targeting RNA for the Multiplexed Detection of Fusion Transcripts and Oncogenic Isoforms
Authors: Sussman Robyn T. , Oran Amanda R. , Paolillo Carmela , Lieberman David , Morrissette Jennifer J. D. , Rosenbaum Jason N. 
Published: June 2019

Context.—Next-generation sequencing is a high-throughput method for detecting genetic abnormalities and providing prognostic and therapeutic information for patients with cancer. Oncogenic fusion transcripts are among the various classifications of genetic abnormalities present in tumors and are typically detected clinically with fluorescence in situ hybridization (FISH). However, FISH probes only exist for a limited number of targets, do not provide any information about fusion partners, cannot be multiplex, and have been shown to be limited in specificity for common targets such as ALK.Objective.—To validate an anchored multiplex polymerase chain reaction–based panel for the detection of fusion transcripts in a university hospital–based clinical molecular diagnostics laboratory.Design.—We used 109 unique clinical specimens to validate a custom panel targeting 104 exon boundaries from 17 genes involved in fusions in solid tumors. The panel can accept as little as 100 ng of total nucleic acid from PreservCyt-fixed tissue, and formalin-fixed, paraffin-embedded specimens with as little as 10% tumor nuclei.Results.—Using FISH as the gold standard, this assay has a sensitivity of 88.46% and a specificity of 95.83% for the detection of fusion transcripts involving ALK, RET, and ROS1 in lung adenocarcinomas. Using a validated next-generation sequencing assay as the orthogonal gold standard for the detection of EGFR variant III (EGFRvIII) in glioblastomas, the assay is 92.31% sensitive and 100% specific.Conclusions.—This multiplexed assay is tumor and fusion partner agnostic and will provide clinical utility in therapy selection for patients with solid tumors.
Assentamentos rurais e as possíveis relações com as dinâmicas de desmatamento na Amazônia: uma revisão sistemática
Authors: De Avila Silvia Regina Starling Assad , Bernardi Jose Vicente Elias , Couto Junior Antonio Felipe , De Avila Mario Lucio 
Published: June 2019

Resumo: Para melhor contemplar e entender a relação existente entre desmatamento no norte do Mato Grosso e sua relação com os assentamentos presentes na região, o objetivo deste texto foi apresentar uma revisão sistemática da literatura sobre assentamentos rurais e possíveis relações com as dinâmicas de desmatamento na Amazônia, pontualmente buscando responder aos questionamentos: 1). Quais os autores têm mais influenciado os estudos na área (até os dias atuais)? 2). Quais periódicos têm dado destaque ao assunto? e 3). Qual o estado da arte na discussão? Para tal, foi escolhida a base de dados SCOPUS para consulta, através da combinação de diferentes palavras chaves relacionadas ao assunto. Os resultados apontaram que os autores que se dedicam ao tema estão no eixo entre Europa, EUA e Brasil e que o assunto se prolifera através de quatro principais periódicos que primam pela interdisciplinaridade e por isso integram economia, ecologia, gestão florestal, além de estudarem políticas públicas e sistemas socioeconômicos sustentáveis. A revisão aponta três fases distintas do processo de uso e ocupação do solo na região, entretanto, não se pode colocar essas fases em uma sequência linear e descontextualizadas das dinâmicas de mercado, ações políticas e pressões de organizações ambientalistas nacionais e internacionais.
50 Years of ITAL/JLA
Authors: Lund Brady 
Published: June 2019

Over five decades, Information Technology and Libraries (and its predecessor, the Journal of Library Automation) has influenced research and practice in the library and information science technology. From its inception on, the journal has been consistently ranked as one of the superior publications in the profession and a trendsetter for all types of librarians and researchers. This research examines ITAL using a citation analysis of all 878 peer-reviewed feature articles published over the journal’s 51 volumes. Impactful authors, articles, publications, and themes from the journal’s history are identified. The findings of this study provide insight into the history of ITAL and potential topics of interest to ITAL authors and readership.