bluuebunny/crossref_metadata_2025_split huggingface dataset:
Title: Early Re-Initiation of Anti-Obesity Medications Post Laparoscopic Sleeve Gastrectomy in Youth: Proof of Concept Trial
Authors: Vidmar Alaina P. , Vu My H. , Martin Matthew J. , Kim Aimee G. , Abel Stuart , Weitzner Madeleine , Munoz Cynthia E. , Kim Ahlee , Samakar Kamran 
Published: November 2024

Abstract

Background
Bariatric surgery is the most effective intervention for severe pediatric obesity, but 25% of youth experience suboptimal weight loss and/or weight regain. A multi-pronged postoperative approach, including early re-initiation of anti-obesity medications (AOM), may improve outcomes, though this has not been evaluated in pediatric populations.
Methods
This pilot study assessed the safety, tolerability, and efficacy of early AOM re-initiation after laparoscopic sleeve gastrectomy (LSG) in youth. A retrospective analysis compared youth undergoing LSG at a large children's hospital from November 2023 to July 2024, comparing those who chose early AOM re-initiation (n = 25) versus standard care (n = 21). Primary outcomes included changes in weight trajectory, eating behaviors, complications, readmissions, and reoperation rates, analyzed using independent t-tests, Chi-squared tests, and logistic regressions.
Results
The study involved 46 adolescents (mean age 16.5 years, mean BMI 50 kg/m², predominantly female (70%), Hispanic (80%), and publicly insured (87%); 93% had used AOM preoperatively). Mixed effect multivariate regression analysis, adjusting for baseline BMI, age, and sex, revealed that early AOM re-initiation (5.1 weeks [IQR 3.7,8.4]) significantly reduced BMI, percent BMI, percent total weight loss (TWL), and percent excess weight loss (EWL) at 3 and 6 months postoperatively compared to standard care, with no significant differences in complications or readmissions. At 6 months, the mean differences were: %BMI: -6.5% (95%CI: -9.13, -3.86), p < 0.001; %TWL: -5.9% (95%CI: -8.52, -3.25), p < 0.001; %EWL: -8.2 (95%CI: -14.69, -1.63), p < 0.001. Early re-initiators reported a 4-fold reduction in emotional overeating (p = 0.001) compared to standard care.
Conclusion
Early AOM re-initiation after LSG was safe and well tolerated, improving weight outcomes without negatively impacting complication or readmission rates.
Endoscopic assessment of terminal ileum in screening colonoscopy: Is it worth the effort?
Authors: Dąbkowski Krzysztof , Tryba Maciej , Biesiada Ernest , Konczanin Kamila , Michalak Małgorzata , Szczygłowska Magdalena , Safranow Krzysztof , Starzyńska Teresa 
Published: November 2024

Abstract

Background
Screening colonoscopies often do not include terminal ileum assessment. Here we examined how often endoscopists assessed the terminal ileum in screening colonoscopy, how it influenced procedure time and patient comfort, and whether it revealed pathological findings.
Methods
We retrospectively analyzed the screening colonoscopy examinations performed in our department (tertiary center and university hospital) between 2017–2021. From our database, we retrieved the procedure duration (minutes), patient age and sex, examination extent (colon vs. small bowel), and screening colonoscopy results. The pain scale (1–5) was obtained from a post-examination patient survey.
Results
A total of 2449 screening colonoscopy examinations were performed in 2017–2021. Patients were divided into two groups: cecum reached (2403 patients; cecal intubation rate, 98.1%) or terminal ileum intubated (297 patients; 12.1%). These two groups did not significantly differ in sex or reported pain score, while the patients were significantly younger ( 55.2 ± 6.5vs 56.2 ± 6 years, P = 0.015) and the colonoscopy duration was significantly longer(22.8 ± 9.8 vs 18 ± 10.5, P < 0.001) in the terminal ileum group. Pathological conditions in the small intestine were reported in 5/297 patients (1.7%)—with non-specific inflammatory lesions in 4, and nodular hyperplasia in 1. None of these 5 patients developed inflammatory bowel disease during follow-up of 25.2 months.
Conclusions
Small intestine intubation was rarely performed in screening colonoscopy, was associated with significant longer colonoscopy duration, and revealed few pathological conditions with no significant clinical meaning. No neoplastic conditions including the neuroendocrine tumors were detected. Routine terminal ileum assessment should not be a mandatory part of screening colonoscopy.
Remnant Cholesterol and Risk of Aortic Aneurysm and Dissection: A Prospective Cohort Study from the UK Biobank Study and Mendelian Randomization Analysis
Authors: Zhou Ting , Lin wenhui , Yang Bangyuan , Xie Nianjin , Liu Yuan , Hu Ziyang , Huang Wenhui , Luo Songyuan , Yang Fan , Luo Jianfang 
Published: November 2024

Abstract

Aim
To investigate the associations between remnant cholesterol (RC) and the risk of aortic aneurysm and dissection (AAD).
Methods
This prospective cohort study included 368,193 European adults from the UK Biobank (UKB). In addition, the causal relationship between RC and AAD was investigated using Mendelian randomization (MR) analyses.
Results
The UKB cohort investigation identified 1634 cases of abdominal aortic aneurysm (AAA), 698 cases of thoracic aortic aneurysm (TAA), and 184 cases of aortic dissection (AD) during a median follow-up time of 13.65 years. High RC was shown to be linked to a higher risk of AAA when compared to the reference RC ([most vs least]: adjusted HR = 1.63, 95% CI 1.33–2.00). Nevertheless, a high RC exhibited only a minimal correlation with a risk of TAA and AD. Two-sample MR analyses revealed a significant causal effect of RC on the risk of AAA (odds ratio = 2.42, 95% confidence range = 1.91–3.06). Even after accounting for HDL-C and LDL-C, this relationship was still statistically significant. However, the MR analysis findings indicated that there was no overall causal relationship between RC and either AD or TAA.
Conclusions
The risk of incident AAA was heightened with elevated RC levels, and MR analysis provided compelling evidence supporting a causal association between RC and increased risk of AAA. These findings suggest that RC could serve as a novel predictor for AAA and may play a crucial role in AAA prevention strategies.
Daily runoff prediction based on lightweight Mamba with partial normalization
Authors: Jia Donghuai , Li Weide , Huang Di , Chen Shukai 
Published: November 2024

ABSTRACT

Runoff prediction serves as the cornerstone for the effective management, allocation, and utilization of water resources, playing a key role in hydrological research. This study employs a newly reported deep learning model, Mamba, to forecast river daily runoff and compared the proposed model with various benchmark methods, including statistical models, machine learning methods, recurrent neural networks, and attention-based models. Application of these models is implemented on three hydrological stations situated along the middle and lower reaches of the Mississippi River. Daily runoff from 1983 to 2023 were used to build the model for 7-day prediction. Findings demonstrate the superiority of the Mamba model over its counterparts, showcasing its potential as a backbone model. In response to the necessity for a more lightweight approach, a refined variant of the Mamba model is proposed, called LightMamba. LightMamba incorporates partial normalization and MPM (Multi-Path-Mamba) to enhance its efficacy in discerning nonlinear trends and capturing long-term dependencies within the streamflow data. Notably, LightMamba achieves commendable performance with an average NSE of 0.904, 0.907, and 0.900 on the three stations. This study introduces an innovative backbone model for time series forecasting, which offers a novel approach to hybrid modeling for future daily runoff prediction.
Design Optimization and Evaluation of Patented Fast-Dissolving Oral Thin Film of Ambrisentan for the Treatment of Hypertension
Authors: Kanugo Abhishek 
Published: November 2024

Background:
Cardiovascular diseases, including hypertension, are the prominent source
of death globally. High blood pressure is responsible for heart failure and also damages the vital organs
of the body, which also creates mortality. The activation of the sympathetic nervous system in
the primary sunrise period is a highly critical condition, and several persons have lost their tissue due
to the unavailability of medicine at this time.

Objective:
The present research deals with the progress of fast-dissolving oral thin film (OTF) of
Ambrisentan for the prevention and cure of hypertension.

Methods:
The OTF was established using the solvent casting method. The compatibility of Ambrisentan
with film former HPMC E15 was checked with FTIR and DSC. The optimization was assessed
using the design of the experiment using 32 Box-Behnken designs. The independent parameters were
filmed former (X1: HPMC E15), plasticizer (X2: PEG 400), and super disintegrant (X3: cross povidone)
and dependable parameters were disintegration time (Y1) and dissolution release (Y2).

Results:
The optimized batch F7 showed the least disintegration time (9 sec), folding endurance of
(99), content uniformity (98.57 %), pH (6.4), and dissolved within 5 min. The scanning electron microscopy
confirmed the evenness and smoothness of the film with a particle size of 10 μm. Patent
related with OTF (Indian- 202321050359), US (11701339).

Conclusion:
The investigation indicated that fast dissolving oral thin film of Ambrisentan improves
the solubility and therapeutic efficacy in the prevention and treatment of cardiovascular complications.
The prompt release of Ambrisentan minimizes the mortality associated with heart attack and
hypertension.
Rehabilomics Strategies Enabled by Cloud-Based Rehabilitation: Scoping Review
Authors: Oh Sejun , Lee SangHeon 
Published: November 2024

Background
Rehabilomics, or the integration of rehabilitation with genomics, proteomics, metabolomics, and other “-omics” fields, aims to promote personalized approaches to rehabilitation care. Cloud-based rehabilitation offers streamlined patient data management and sharing and could potentially play a significant role in advancing rehabilomics research. This study explored the current status and potential benefits of implementing rehabilomics strategies through cloud-based rehabilitation.

Objective
This scoping review aimed to investigate the implementation of rehabilomics strategies through cloud-based rehabilitation and summarize the current state of knowledge within the research domain. This analysis aims to understand the impact of cloud platforms on the field of rehabilomics and provide insights into future research directions.

Methods
In this scoping review, we systematically searched major academic databases, including CINAHL, Embase, Google Scholar, PubMed, MEDLINE, ScienceDirect, Scopus, and Web of Science to identify relevant studies and apply predefined inclusion criteria to select appropriate studies. Subsequently, we analyzed 28 selected papers to identify trends and insights regarding cloud-based rehabilitation and rehabilomics within this study’s landscape.

Results
This study reports the various applications and outcomes of implementing rehabilomics strategies through cloud-based rehabilitation. In particular, a comprehensive analysis was conducted on 28 studies, including 16 (57%) focused on personalized rehabilitation and 12 (43%) on data security and privacy. The distribution of articles among the 28 studies based on specific keywords included 3 (11%) on the cloud, 4 (14%) on platforms, 4 (14%) on hospitals and rehabilitation centers, 5 (18%) on telehealth, 5 (18%) on home and community, and 7 (25%) on disease and disability. Cloud platforms offer new possibilities for data sharing and collaboration in rehabilomics research, underpinning a patient-centered approach and enhancing the development of personalized therapeutic strategies.

Conclusions
This scoping review highlights the potential significance of cloud-based rehabilomics strategies in the field of rehabilitation. The use of cloud platforms is expected to strengthen patient-centered data management and collaboration, contributing to the advancement of innovative strategies and therapeutic developments in rehabilomics.
Improving Pediatric Patients’ Magnetic Resonance Imaging Experience With an In-Bore Solution: Design and Usability Study
Authors: Heuvelink Annerieke , Saini Privender , Taşar Özgür , Nauts Sanne 
Published: November 2024

Background
Annually, millions of children undergo a magnetic resonance imaging (MRI) examination. Hospitals increasingly aim to scan young children awake, as doing so benefits both patients and health care systems. To help hospitals reduce the need for anesthesia, we have developed solutions to prepare pediatric patients at home and in the hospital.

Objective
The goal of our project was to design, develop, and test a solution that extends our preparation solutions by guiding and engaging children during their MRI examination.

Methods
Pediatric In-bore was designed to deliver a familiar experience by reusing design elements from our preparation solutions. It offers child-friendly movies and auditory and visual guidance about examination progress and breath holding. To evaluate children’s liking and understanding of the solution, we conducted a usability study. Ten healthy children participated in a mock MRI examination featuring pediatric In-bore. We observed task compliance (ability to lie still and hold one’s breath) and conducted guided interviews to assess their experience and understanding of the guidance offered.

Results
Participants (aged 5 to 10 years) were generally positive about pediatric In-bore. They liked the main character (Ollie the elephant) and her movie. Auditory and visual guidance were generally liked and understood. All but one participant successfully managed to lie still during the mock examination, and 6 (60%) out of 10 participants successfully held their breath.

Conclusions
Pediatric In-bore appears promising for engaging and guiding young children during awake MRI. It completes the Pediatric Coaching solution that now offers guidance throughout the MRI journey. Future research can expand on this work by evaluating the clinical impact of the Pediatric Coaching solution in a larger and more diverse sample of pediatric patients.
The Use of Social Media on Enhancing Dental Care and Practice Among Dental Professionals: Cross-Sectional Survey Study
Authors: Acosta Joseph Macadaeg , Detsomboonrat Palinee , Pisarnturakit Pagaporn Pantuwadee , Urwannachotima Nipaporn 
Published: November 2024

Abstract

Background
As digitalization continues to advance globally, the health care sector, including dental practice, increasingly recognizes social media as a vital tool for health care promotion, patient recruitment, marketing, and communication strategies.

Objective
This study aimed to investigate the use of social media and assess its impact on enhancing dental care and practice among dental professionals in the Philippines.

Methods
A cross-sectional survey was conducted among dental practitioners in the Philippines. The study used a 23-item questionnaire, which included 5 questions on dentists’ background and demographic information and 18 questions regarding the use, frequency, and purpose of social media in patient advising and quality of care improvement. Data were analyzed using SPSS software, with frequency distributions and χ2 tests used to assess the association between social media use and demographic variables and the impact on dental practice.

Results
The 265 dental practitioners in this study were predominantly female (n=204, 77%) and aged between 20‐30 years (n=145, 54.7%). Most of the participants were general practitioners (n=260, 98.1%) working in a private practice (n=240, 90.6%), with 58.5% (n=155) having 0‐5 years of clinical experience. Social media use was significantly higher among younger practitioners (20‐30 years old) compared to older age groups (P<.001), though factors such as sex, dental specialty, and years of clinical practice did not significantly influence use. The majority (n=179, 67.5%) reported using social media in their practice, primarily for oral health promotion and education (n=191, 72.1%), connecting with patients and colleagues (n=165, 62.3%), and marketing (n=150, 56.6%). Facebook (n=179, 67.5%) and YouTube (n=163, 61.5%) were the most frequented platforms for clinical information, with Twitter (subsequently rebranded X) being the least used (n=4, 1.5%). Despite widespread social media engagement, only 8.7% (n=23) trusted the credibility of web-based information, and 63.4% (n=168) perceived a potential impact on the patient-dentist relationship due to patients seeking information on the internet. Social media was also perceived to enhance practice quality, with users reporting significant improvements in patient care (P=.001).

Conclusions
The findings highlight that social media is widely used among younger dental practitioners, primarily for education, communication, and marketing purposes. While social media use is associated with perceived improvements in practice quality and patient care, trust in information on social media remains low, and concerns remain regarding its effect on patient relationships. It is recommended to establish enhanced guidelines and provide reliable web-based resources to help dental practitioners use social media effectively and responsibly.
CEO Dualism and Corporate Value: A Digital Corporate Governance Perspective
Authors: Galuh Febrianto Hendra , Mikrad  , Eky Pambudi Januar 
Published: November 2024

Research aims: The aim of this research isto test and analyze the influence of CEO dualism on digital governance, General Meeting of Shareholders (GMS) and Cash ETR. Then digital corporate governance, and Cash ETR influence firm value.
Design/Methodology/Approach: This research uses a quantitative approach based on associative-causality. As for the data collection techniques used in this research, it is the study of libraries and documentation of secondary data. This study uses path analysis (Path Analysis).
Research findings: The results of this study are CEO dualism giving positive and significant influence on digital corporate governance, GMS and Cash ETR. In addition, digital corporate governance and Cash RTR also give positive and meaningful influence to firm value.
Theoretical contribution/ Originality: The research provides a theoretical contribution that in discussing agency theory and stewardship theory there is a gap where the interests of managers that are always different in the interest of stakeholders have a gap with the theory of stewardships that wants the existence of managers to take precedence on cohesion, partnership, empowerment and mutual trust.
Practitioner/Policy implication: The policy implications obtained in this study are the importance of the government in elevating policies in particular that relate to taxes on companies that already involve management as well as digital transactions as planned by the OECD.
Research limitation/Implication: The research has the limitation that companies that go public on the Indonesian stock exchange have not fully implemented digital governance and implemented GMS digitally, so not all consumer goods companies are listed as samples of research.
Acute treatment of elderly patients with acetabular fractures by open reduction, internal fixation, and total hip arthroplasty: a 1–10-year follow-up of 48 patients
Authors: Kirkeboe Ragnhild Loven , Madsen Jan Erik , Nordsletten Lars , Clarke-Jenssen John 
Published: November 2024

Background and purpose: Acetabular fractures in osteoporotic bone are associated with substantial joint impaction and comminution, previously shown to be prognostic for a poor result. A combined procedure of open reduction, internal fixation (ORIF), and total hip arthroplasty (THA) can be a good option, allowing for immediate weightbearing as tolerated. We report short- to medium-term outcome and complications of the results of patients treated with this combined procedure.Methods: 48 cases treated with ORIF and acute THA from 2000 to 2019 were identified from our local pelvic fracture registry, from which follow-up data was extracted. Descriptive statistics were used and Kaplan–Meier survival curves were calculated. Primary outcome was HHS at 1 year. Secondary outcomes were implant survival, complications requiring surgery, and mortality at 3 months.Results: There were 37 men and 11 women treated in the study period. Mean age was 68 (37–87) years. 6 patients died within 3 months of surgery, leaving 42 cases available for follow-up. Mean follow-up (FU) was 2.8 (1–16) years. The most common mechanism of injury was fall from standing height (n = 36). Medical comorbidities were common. Mean Harris Hip Score (HHS) was 83 (51–100) at 1-year follow-up. There were 7 reoperations: 6 for postoperative infection and 1 closed reduction of implant dislocation. 38 had their implant intact at latest FU. At the latest FU, 28 patients were ambulatory without a walking aid.Conclusion: Our results indicate that ORIF and acute THA can be performed with good functional results in patients with unreconstructable displaced acetabular fractures, but with a significant risk of infection and revision.
SYTIN IVAN DMITRIEVICH. BOOK PATRON OF RUSSIA
Authors: I.V. Bocharnikov , O.A. Ovsyannikova 
Published: November 2024

The article analyzes the life of the founder of the largest publishing company in pre-revolutionary Russia, the outstanding Russian entrepreneur Ivan Dmitrievich Sytin. The main stages of his activity in the sphere of book publishing as the initiator of several dozens of publishing projects, such as textbooks and books for children, encyclopedias, collected works of classics of fiction, popular periodicals are defined. It was largely thanks to the publishing activities of I. D. Sytin that Russian society at the turn of the XIX XX centuries gained access to domestic and foreign literature. The most important activity of I. D. Sytin was enlightenment-preparation and production of accessible universal reference books, textbooks, literature for children, specialists in various fields of activity. Making his goal in life to educate the people, I. D. Sytin achieved that by the beginning of the XX century his company produced a quarter of all printed publications in the country, and Russia became the most reading country in the world. Such activities had no analogues in the world, which naturally raises I. D. Sytin to the rank of an outstanding Russian educator and philanthropist, who devoted himself to the noble cause of educating his people.
В статье анализируется жизненный путь создателя самой крупной в дореволюционной России издательской компании, выдающегося русского предпринимателя Ивана Дмитриевича Сытина. Определяются основные этапы его деятельности в сфере книгоиздательства как инициатора нескольких десятков издательских проектов, таких как: учебники и книги для детей, энциклопедии, собрания сочинений классиков художественной литературы, популярные периодические издания. В значительной мере именно благодаря издательской деятельности И.Д.Сытина русское общество на рубеже XIX XX веков получило доступ к отечественной и зарубежной литературе. Важнейшим направлением деятельности И.Д.Сытина стало просветительство подготовка и выпуск доступных универсальных справочных изданий, учебных пособий, литературы для детей, специалистов различного профиля деятельности. Сделав своей целью в жизни просвещение народа, И.Д.Сытин добился того, что к началу XX столетия его компании выпускали четверть всех печатных изданий в стране, а Россия стала самой читающее страной в мире. Подобного рода деятельность не имела аналога в мире, что закономерно возводит И.Д.Сытина в ранг выдающегося русского просветителя и мецената, посвятившего себя благородному делу просвещения своего народа.