bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design Considerations for Therapeutic Devices - An Investigation of Pre-Schoolers’ Preferences for an Artefact’s Basic Characteristics
Authors: Balzan Emanuel , Farrugia Philip , Casha Owen , Camilleri Liberato , Wodehouse Andrew 
Published: July 2019

AbstractToys are children's first consumer products and while playing they acquire numerous skills, learn about their environment and socialise with other children and adults. Toys are adapted and used by clinicians as therapeutic devices because they allow them to create bonds and communicate with children. Aesthetical aspects should be considered early in the design process, especially since pre-schoolers’ views are still dominated by the appearance of artefacts, also known as, the perceptual salient characteristics. The study of emotions mediates the understanding of the relationships between a product, user and the process with which consumers set up preferences over products. Decisions taken in each design stage will influence whether therapeutic devices will be enjoyed by children. An experiment was carried out to test out pre-schoolers’ preferences on individual attributes: form, dimension, material (hardness and weight) and surface (appearance and texture). This study exposed dominant characteristic preferences and the fact that some are influenced by gender and age. Employing these findings in therapeutic devices will enable clinicians to better engage the children during therapy.
Image-based modelling of the skin-friction coefficient in compressible boundary-layer transition
Authors: Zheng Wenjie , Ruan Shanxin , Yang Yue , He Lin , Chen Shiyi 
Published: July 2019

We develop a model of the skin-friction coefficient based on scalar images in the compressible, spatially evolving boundary-layer transition. The images are extracted from a passive scalar field by a sliding window filter on the streamwise and wall-normal plane. The multi-scale and multi-directional geometric analysis is applied to characterize the averaged inclination angle of spatially evolving filtered component fields at different scales ranging from a boundary-layer thickness to several viscous length scales. In general, the averaged inclination angles increase along the streamwise direction, and the variation of the angles for large-scale structures is smaller than that for small-scale structures. Inspired by the coincidence of the increasing averaged inclination angle and the rise of the skin-friction coefficient, we propose a simple image-based model of the skin-friction coefficient. The model blends empirical formulae of the skin-friction coefficient in laminar and fully developed turbulent regions using the normalized averaged inclination angle of scalar structures at intermediate and small scales. The model prediction calculated from scalar images is validated by the results from the direct numerical simulation at two Mach numbers, 2.25 and 6, and the relative error can be less than 15 %.
Defining Romantic Self-Sabotage: A Thematic Analysis of Interviews With Practising Psychologists
Authors: Peel Raquel , Caltabiano Nerina , Buckby Beryl , McBain Kerry 
Published: July 2019

Abstract
The term ‘self-sabotage’ is not well defined in the current literature. Self-sabotage is generally explained as a synonym of self-handicapping, which does not fully encompass intrinsic behaviours found in romantic relationships. Therefore, the aim of the present study was to explore the theme of self-sabotage as viewed by practising psychologists. A series of 15 semistructured interviews with psychologists specialising in romantic relationships around Australia identified the main issues contributing to self-sabotage in romantic relationships and the reason why it might happen. Future studies will need to be conducted to develop a scale to empirically test self-sabotage in romantic relationships.
Association of dietary patterns with depressive symptoms in Chinese postmenopausal women
Authors: Liao Kuan , Gu Yeqing , Liu Mingyue , Fu Jingzhu , Wang Xiaotong , Yang Guanlin , Zhang Qing , Liu Li , Meng Ge , Yao Zhanxin , Wu Hongmei , Xia Yang , Bao Xue , Zhang Shunming , Sun Shaomei , Wang Xing , Zhou Ming , Jiao Huanli , Jia Qiyu , Song Kun , Wu Yuntang , Niu Kaijun 
Published: July 2019

AbstractMany components in diet have regulated oxidative stress, inflammatory reaction and even balance oestrogen levels. Because these factors are closely associated with depressive symptoms in postmenopausal women, it is considered that dietary factors are able to prevent and control depressive symptoms. On the other hand, a dietary pattern that considers the correlations and synergies between foods and nutrients is expected to have a greater impact on disease risk. The aim of the present study is to evaluate whether dietary patterns are associated with depressive symptoms in Chinese postmenopausal women. A cross-sectional study of 2051 postmenopausal women (mean age: 58·8 (sd 7·4) years) was conducted in Tianjin, China. Dietary consumption was assessed by a valid self-administered FFQ. Principal component analysis was used to derive three major dietary patterns: ‘healthy’, ‘sweets’ and ‘traditional Tianjin’ from eighty-eight food items. Depressive symptoms were assessed using the Zung Self-Rating Depression Scale, and cut-off point of 48 indicating serious depressive symptoms. The association between quartile of dietary patterns and depressive symptoms was assessed using multiple logistic regression analysis. The multivariable-adjusted OR of having depressive symptoms for increasing quartile of dietary patterns were as follows: healthy, 1·00, 0·79 (95 % CI 0·49, 1·28), 0·62 (95 % CI 0·37, 1·04) and 0·57 (95 % CI 0·33, 0·97); sweets, 1·00, 0·75 (95 % CI 0·42, 1·3), 1·08 (95 % CI 0·64, 1·81) and 1·66 (95 % CI 1·03, 2·71); and traditional Tianjin, 1·00, 1·02 (95 % CI 0·58, 1·79), 0·96 (95 % CI 0·54, 1·71) and 2·53 (95 % CI 1·58, 4·16), respectively. The present study demonstrated that a healthy dietary pattern was inversely associated with depressive symptoms. On the contrary, greater adherence to sweets and traditional Tianjin dietary patterns was associated with a higher prevalence of depressive symptoms.
Towards ultra-intense ultra-short ion beams driven by a multi-PW laser
Authors: Badziak J. , Domański J. 
Published: July 2019

AbstractThe multi-petawatt (PW) lasers currently being built in Europe as part of the Extreme Light Infrastructure (ELI) project will be capable of generating femtosecond light pulses of ultra-relativistic intensities (~1023–1024 W/cm2) that have been unattainable so far. Such laser pulses can be used for the production of high-energy ion beams with unique features that could be applied in various fields of scientific and technological research. In this paper, the prospect of producing ultra-intense (intensity ≥1020 W/cm2) ultra-short (pico- or femtosecond) high-energy ion beams using multi-PW lasers is outlined. The results of numerical studies on the acceleration of light (carbon) ions, medium-heavy (copper) ions and super-heavy (lead) ions driven by a femtosecond laser pulse of ultra-relativistic intensity, performed with the use of a multi-dimensional (2D3 V) particle-in-cell code, are presented, and the ion acceleration mechanisms and properties of the generated ion beams are discussed. It is shown that both in the case of light ions and in the case of medium-heavy and super-heavy ions, ultra-intense femtosecond multi-GeV ion beams with a beam intensity much higher (by a factor ~102) and ion pulse durations much shorter (by a factor ~104–105) than achievable presently in conventional radio frequency-driven accelerators can be produced at laser intensities of 1023 W/cm2 predicted for the ELI lasers. Such ion beams can open the door to new areas of research in high-energy density physics, nuclear physics and inertial confinement fusion.
Biological sensitivity to context: A test of the hypothesized U-shaped relation between early adversity and stress responsivity
Authors: Shakiba Nila , Ellis Bruce J. , Bush Nicole R. , Boyce W. Thomas 
Published: July 2019

AbstractWe conducted signal detection analyses to test for curvilinear, U-shaped relations between early experiences of adversity and heightened physiological responses to challenge, as proposed by biological sensitivity to context theory. Based on analysis of an ethnically diverse sample of 338 kindergarten children (4–6 years old) and their families, we identified levels and types of adversity that, singly and interactively, predicted high (top 25%) and low (bottom 25%) rates of stress reactivity. The results offered support for the hypothesized U-shaped curve and conceptually replicated and extended the work of Ellis, Essex, and Boyce (2005). Across both sympathetic and adrenocortical systems, a disproportionate number of children growing up under conditions characterized by either low or high adversity (as indexed by restrictive parenting, family stress, and family economic condition) displayed heightened stress reactivity, compared with peers growing up under conditions of moderate adversity. Finally, as hypothesized by the adaptive calibration model, a disproportionate number of children who experienced exceptionally stressful family conditions displayed blunted cortisol reactivity to stress.
Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
Authors: Deng Liping , Ren Ruotong , Liu Zunpeng , Song Moshi , Li Jingyi , Wu Zeming , Ren Xiaoqing , Fu Lina , Li Wei , Zhang Weiqi , Guillen Pedro , Izpisua Belmonte Juan Carlos , Chan Piu , Qu Jing , Liu Guang-Hui 
Published: July 2019

AbstractDiGeorge syndrome critical region 8 (DGCR8) is a critical component of the canonical microprocessor complex for microRNA biogenesis. However, the non-canonical functions of DGCR8 have not been studied. Here, we demonstrate that DGCR8 plays an important role in maintaining heterochromatin organization and attenuating aging. An N-terminal-truncated version of DGCR8 (DR8dex2) accelerated senescence in human mesenchymal stem cells (hMSCs) independent of its microRNA-processing activity. Further studies revealed that DGCR8 maintained heterochromatin organization by interacting with the nuclear envelope protein Lamin B1, and heterochromatin-associated proteins, KAP1 and HP1γ. Overexpression of any of these proteins, including DGCR8, reversed premature senescent phenotypes in DR8dex2 hMSCs. Finally, DGCR8 was downregulated in pathologically and naturally aged hMSCs, whereas DGCR8 overexpression alleviated hMSC aging and mouse osteoarthritis. Taken together, these analyses uncovered a novel, microRNA processing-independent role in maintaining heterochromatin organization and attenuating senescence by DGCR8, thus representing a new therapeutic target for alleviating human aging-related disorders.
Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation
Authors: Chen Dong-Yuan , Crest Justin , Streichan Sebastian J. , Bilder David 
Published: July 2019

AbstractOrgans are sculpted by extracellular as well as cell-intrinsic forces, but how collective cell dynamics are orchestrated in response to environmental cues is poorly understood. Here we apply advanced image analysis to reveal extracellular matrix-responsive cell behaviors that drive elongation of the Drosophila follicle, a model system in which basement membrane stiffness instructs three-dimensional tissue morphogenesis. Through in toto morphometric analyses of wild type and round egg mutants, we find that neither changes in average cell shape nor oriented cell division are required for appropriate organ shape. Instead, a major element is the reorientation of elongated cells at the follicle anterior. Polarized reorientation is regulated by mechanical cues from the basement membrane, which are transduced by the Src tyrosine kinase to alter junctional E-cadherin trafficking. This mechanosensitive cellular behavior represents a conserved mechanism that can elongate edgeless tubular epithelia in a process distinct from those that elongate bounded, planar epithelia.
Self-sustained biphasic catalytic particle turbulence
Authors: Wang Ziqi , Mathai Varghese , Sun Chao 
Published: July 2019

AbstractTurbulence is known for its ability to vigorously mix fluid and transport heat. Despite over a century of research for enhancing heat transport, few have exceeded the inherent limits posed by turbulent-mixing. Here we have conceptualized a kind of “active particle” turbulence, which far exceeds the limits of classical thermal turbulence. By adding a minute concentration (ϕv ∼ 1%) of a heavy liquid (hydrofluoroether) to a water-based turbulent convection system, a remarkably efficient biphasic dynamics is born, which supersedes turbulent heat transport by up to 500%. The system operates on a self-sustained dynamically equilibrated cycle of a “catalyst-like” species, and exploits several heat-carrier agents including pseudo-turbulence, latent heat and bidirectional wake capture. We find that the heat transfer enhancement is dominated by the kinematics of the active elements and their induced-agitation. The present finding opens the door towards the establishment of tunable, ultra-high efficiency heat transfer/mixing systems.
Molecular mechanism of cytoplasmic dynein tension sensing
Authors: Rao Lu , Berger Florian , Nicholas Matthew P. , Gennerich Arne 
Published: July 2019

AbstractCytoplasmic dynein is the most complex cytoskeletal motor protein and is responsible for numerous biological functions. Essential to dynein’s function is its capacity to respond anisotropically to tension, so that its microtubule-binding domains bind microtubules more strongly when under backward load than forward load. The structural mechanisms by which dynein senses directional tension, however, are unknown. Using a combination of optical tweezers, mutagenesis, and chemical cross-linking, we show that three structural elements protruding from the motor domain—the linker, buttress, and stalk—together regulate directional tension-sensing. We demonstrate that dynein’s anisotropic response to directional tension is mediated by sliding of the coiled-coils of the stalk, and that coordinated conformational changes of dynein’s linker and buttress control this process. We also demonstrate that the stalk coiled-coils assume a previously undescribed registry during dynein’s stepping cycle. We propose a revised model of dynein’s mechanochemical cycle which accounts for our findings.
A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
Authors: Handa James T. , Bowes Rickman Cathy , Dick Andrew D. , Gorin Michael B. , Miller Joan W. , Toth Cynthia A. , Ueffing Marius , Zarbin Marco , Farrer Lindsay A. 
Published: July 2019

AbstractAge-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or “wet” form of AMD, no therapy is successful for the non-neovascular or “dry” form. Here we discuss the current knowledge on dry AMD pathobiology and propose future research directions that would expedite the development of new treatments. In our view, these should emphasize system biology approaches that integrate omic, pharmacological, and clinical data into mathematical models that can predict disease onset and progression, identify biomarkers, establish disease causing mechanisms, and monitor response to therapy.
Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1
Authors: Leclerc Marine , Voilin Elodie , Gros Gwendoline , Corgnac Stéphanie , de Montpréville Vincent , Validire Pierre , Bismuth Georges , Mami-Chouaib Fathia 
Published: July 2019

AbstractNeuropilin-1 (Nrp-1) is a marker for murine CD4+FoxP3+ regulatory T (Treg) cells, a subset of human CD4+ Treg cells, and a population of CD8+ T cells infiltrating certain solid tumours. However, whether Nrp-1 regulates tumour-specific CD8 T-cell responses is still unclear. Here we show that Nrp-1 defines a subset of CD8+ T cells displaying PD-1hi status and infiltrating human lung cancer. Interaction of Nrp-1 with its ligand semaphorin-3A inhibits migration and tumour-specific lytic function of cytotoxic T lymphocytes. In vivo, Nrp-1+PD-1hi CD8+ tumour-infiltrating lymphocytes (TIL) in B16F10 melanoma are enriched for tumour-reactive T cells exhibiting an exhausted state, expressing Tim-3, LAG-3 and CTLA-4 inhibitory receptors. Anti-Nrp-1 neutralising antibodies enhance the migration and cytotoxicity of Nrp-1+PD-1hi CD8+ TIL ex vivo, while in vivo immunotherapeutic blockade of Nrp-1 synergises with anti-PD-1 to enhance CD8+ T-cell proliferation, cytotoxicity and tumour control. Thus, Nrp-1 could be a target for developing combined immunotherapies.
Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
Authors: Khurana Surender , Hahn Megan , Coyle Elizabeth M. , King Lisa R. , Lin Tsai-Lien , Treanor John , Sant Andrea , Golding Hana 
Published: July 2019

AbstractSeveral vaccines are approved in the United States for seasonal influenza vaccination every year. Here we compare the impact of repeat influenza vaccination on hemagglutination inhibition (HI) titers, antibody binding and affinity maturation to individual hemagglutinin (HA) domains, HA1 and HA2, across vaccine platforms. Fold change in HI and antibody binding to HA1 trends higher for H1N1pdm09 and H3N2 but not against B strains in groups vaccinated with FluBlok compared with FluCelvax and Fluzone. Antibody-affinity maturation occurs against HA1 domain of H1N1pdm09, H3N2 and B following vaccination with all vaccine platforms, but not against H1N1pdm09-HA2. Importantly, prior year vaccination of subjects receiving repeat vaccinations demonstrated reduced antibody-affinity maturation to HA1 of all three influenza virus strains irrespective of the vaccine platform. This study identifies an important impact of repeat vaccination on antibody-affinity maturation following vaccination, which may contribute to lower vaccine effectiveness of seasonal influenza vaccines in humans
Reconfigurable two-dimensional optoelectronic devices enabled by local ferroelectric polarization
Authors: Lv Liang , Zhuge Fuwei , Xie Fengjun , Xiong Xujing , Zhang Qingfu , Zhang Nan , Huang Yu , Zhai Tianyou 
Published: July 2019

AbstractFerroelectric engineered pn doping in two-dimensional (2D) semiconductors hold essential promise in realizing customized functional devices in a reconfigurable manner. Here, we report the successful pn doping in molybdenum disulfide (MoS2) optoelectronic device by local patterned ferroelectric polarization, and its configuration into lateral diode and npn bipolar phototransistors for photodetection from such a versatile playground. The lateral pn diode formed in this way manifests efficient self-powered detection by separating ~12% photo-generated electrons and holes. When polarized as bipolar phototransistor, the device is customized with a gain ~1000 by its transistor action, reaching the responsivity ~12 A W−1 and detectivity over 1013 Jones while keeping a fast response speed within 20 μs. A promising pathway toward high performance optoelectronics is thus opened up based on local ferroelectric polarization coupled 2D semiconductors.
The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression
Authors: Mazumdar Abhijit , Tahaney William M. , Reddy Bollu Lakshmi , Poage Graham , Hill Jamal , Zhang Yun , Mills Gordon B. , Brown Powel H. 
Published: July 2019

AbstractEstrogen receptor (ER)-negative, progesterone receptor (PR)-negative and HER2-negative, or “triple negative,” breast cancer (TNBC) is a poor prognosis clinical subtype that occurs more frequently in younger women and is commonly treated with toxic chemotherapy. Effective targeted therapy for TNBC is urgently needed. Our previous studies have identified several kinases critical for TNBC growth. Since phosphatases regulate the function of kinase signaling pathways, we sought to identify critical growth-regulatory phosphatases that are expressed differentially in ER-negative, as compared to ER-positive, breast cancers. In this study, we examined the role of one of these differentially expressed phosphatases, the protein phosphatase Mg + 2/Mn + 2 dependent 1A (PPM1A) which is underexpressed in ER-negative breast cancer as compared to ER-positive breast cancers, in regulating TNBC growth. We found that PPM1A is deleted in ~40% of ER-negative breast cancers, and that induced expression of PPM1A suppresses in vitro and in vivo growth of TNBC cells. This study demonstrates that induction of PPM1A expression blocks the cell cycle and reduces CDK and Rb phosphorylation. These results suggest PPM1A is a crucial regulator of cell cycle progression in triple negative breast cancer. Our results also suggest that PPM1A loss should be explored as a predictive biomarker of CDK inhibitor sensitivity.
Quantum key distribution with flawed and leaky sources
Authors: Pereira Margarida , Curty Marcos , Tamaki Kiyoshi 
Published: July 2019

AbstractIn theory, quantum key distribution (QKD) allows secure communications between two parties based on physical laws. However, most of the security proofs of QKD today make unrealistic assumptions and neglect many relevant device imperfections. As a result, they cannot guarantee the security of the practical implementations. Recently, the loss-tolerant protocol (K. Tamaki et al., Phys. Rev. A, 90, 052314, 2014) was proposed to make QKD robust against state preparation flaws. This protocol relies on the emission of qubit systems, which, unfortunately, is difficult to achieve in practice. In this work, we remove such qubit assumption and generalise the loss-tolerant protocol to accommodate multiple optical modes in the emitted signals. These multiple optical modes could arise, e.g., from Trojan horse attacks and/or device imperfections. Our security proof determines some dominant device parameter regimes needed for achieving secure communication and, therefore, it can serve as a guideline to characterise QKD transmitters. Furthermore, we compare our approach with that of H.-K. Lo et al. (Quantum Inf. Comput., 7, 431–458, 2007) and identify which method provides the highest secret key generation rate as a function of the device imperfections. Our work constitutes an important step towards the best practical and secure implementation for QKD.
A non-enzymatic glucose sensor enabled by bioelectronic pH control
Authors: Strakosas Xenofon , Selberg John , Pansodtee Pattawong , Yonas Nebyu , Manapongpun Pattawut , Teodorescu Mircea , Rolandi Marco 
Published: July 2019

AbstractContinuous glucose monitoring from sweat and tears can improve the quality of life of diabetic patients and provide data for more accurate diagnosis and treatment. Current continuous glucose sensors use enzymes with a one-to-two week lifespan, which forces periodic replacement. Metal oxide sensors are an alternative to enzymatic sensors with a longer lifetime. However, metal oxide sensors do not operate in sweat and tears because they function at high pH (pH > 10), and sweat and tears are neutral (pH = 7). Here, we introduce a non-enzymatic metal oxide glucose sensor that functions in neutral fluids by electronically inducing a reversible and localized pH change. We demonstrate glucose monitoring at physiologically relevant levels in neutral fluids mimicking sweat, and wireless communication with a personal computer via an integrated circuit board.