bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody
Authors: Yamaguchi Kakuhiro , Iwamoto Hiroshi , Sakamoto Shinjiro , Horimasu Yasushi , Masuda Takeshi , Miyamoto Shintaro , Nakashima Taku , Ohshimo Shinichiro , Fujitaka Kazunori , Hamada Hironobu , Kohno Nobuoki , Hattori Noboru 
Published: December 2018

Abstract
The aim of this study was to evaluate whether serial measurements of serum Krebs von den Lungen-6 (KL-6) could be used to monitor disease activity and to detect recurrence in patients with interstitial pneumonia (IP) with anti-aminoacyl-tRNA synthetase antibodies (ARS-IP).
This retrospective cohort study included 44 patients with ARS-IP. Thirty-six patients had serial data of blood tests and pulmonary function tests. Baseline and longitudinal analyses were performed to investigate whether lung function parameters were associated with serum biomarkers (KL-6, lactate dehydrogenase [LDH], and C-reactive protein [CRP]) using Pearson correlation coefficient. Additionally, the diagnostic accuracy of changes in these biomarkers for detecting ARS-IP recurrence was analyzed by receiver operating characteristic curve analysis.
Baseline levels of serum KL-6 were significantly associated with vital capacity (VC) and diffusion capacity for carbon monoxide (DLco) (r = −0.40, P = .015, and r = −0.44, P = .010, respectively). Longitudinal changes in KL-6 were inversely correlated with changes in VC and DLco (r = −0.57, P <.001 and r = −0.42, P <.001, respectively), whereas those in LDH and CRP were not. Moreover, longitudinal changes in serum KL-6 were significantly associated with recurrence of ARS-IP and could be used to detect ARS-IP recurrence; the area under the curve was 0.79 (P = .002).
The present study demonstrated that serial measurement of KL-6 is useful for monitoring disease activity and detecting recurrence of ARS-IP.
A long time radiological follow-up of neuronal intranuclear inclusion disease
Authors: Chen Linglong , Wu Lin , Li Shenghong , Huang Qin , Xiong Jiajun , Hong Daojun , Zeng Xianjun 
Published: December 2018

Abstract

Rationale:
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease identified with diffusion-weighted imaging (DWI) high-intensity signal in magnetic resonance imaging (MRI). The disappearance of the abnormal signal is extremely rare.

Patient concerns:
We present the 2 cases of patients, both of them were suffering from heterogeneous symptoms. We followed up one of them for 7 years with MRI, the other accepted comprehensive MRI inspections.

Diagnoses:
DWI high-intensity signal were observed along the corticomedullary junction in MRI plan scan of heads of 2 patients. For patient 1, the hyperintensities in DWI and fluid-attenuated inversion recovery (FLAIR) images in the occipital lobe disappeared 5 years after onset. Based on the biopsy, patient 1 and 2 were diagnosed as NIID.

Interventions:
There have not effective medication and prevention for NIID. Patient 1 and 2 received symptomatic treatment.

Outcomes:
Up until now, the patients are alive but the disease is progressing.

Lessons:
DWI high-intensity signal is a strong clue for the diagnosis of NIID, but the rare case of the disappearance of it may lead to misdiagnosis.
Laparoscopic extracorporeal repair without a mesh of parasternal diaphragmatic hernia in an elderly woman
Authors: Ni Chen-Hui , Li Huan , Xia Chuan-Bao , Chen Yang-Tian 
Published: December 2018

Abstract

Rationale:
The case of parasternal diaphragmatic hernia is relatively rare in adults. The best way for the treatment of diaphragmatic hernia is to receive operation, yet which surgical method is the best remains unclear.

Patient concerns:
An elderly woman in the hospital was complaining about upper abdominal pain that was complicated by the parasternal diaphragmatic hernia. Such state was found accidentally in a car accident and diagnosed by a computed tomography (CT) scan.

Diagnosis:
Parasternal diaphragmatic hernia.

Interventions:
Laparoscopic surgery was performed. The hernial component was easily drawn back into the abdominal cavity, and hernia sac was resected. Closure hernia sac underwent full-thickness U-shaped transabdominal wall sutures with 3-0 Prolene (ETHICON) after straightening the needle without a mesh.

Outcomes:
The patient recovered quickly without postoperative complication. The hospital stay was 2 days. There was no recurrence and symptoms at a 6-month follow-up.

Lessons:
Laparoscopic extracorporeal repair without using a mesh is a safe, quick, and effective approach. It seems to be an effective treatment of the parasternal diaphragmatic hernia, in particular for elderly patients.
Meta-analysis of the prognostic value of long non-coding RNA PVT1 for cancer patients
Authors: Ma Chao , Nie Xing-Guo , Wang Yan-Li , Wu Da-Peng , Liang Qiu-dong 
Published: December 2018

Abstract

Background:
Plasmacytoma variant translocation 1 (PVT1) is reported to be dysregulated in various cancers. Therefore, this meta-analysis was performed to clarify its utility as a prognosis marker in malignant tumors.

Methods:
Electronic databases, including PubMed, OVID, Cochrane Library, and Web of Science databases, were retrieved from inception to December 16, 2017. Typically, hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were calculated, so as to explore the relationship between PVT1 expression and patient survival. In addition, odds ratios (OR) were calculated to assess the association of PVT1 expression with pathological parameters.

Results:
A total of 23 studies involving 2350 patients were included in this meta-analysis. The pooled HR suggested that high PVT1 expression levels were correlated with poor overall survival (OS, HR = 1.99, 95% CI: 1.73–2.28), disease-free survival (DFS, HR = 1.76, 95% CI: 1.45–2.14), and recurrence-free survival (RFS, HR = 1.74, 95% CI: 1.26–2.39) in cancer patients without obvious heterogeneity. Moreover, high PVT1 expression levels were also correlated with larger tumor size (OR = 1.47, 95% CI: 1.02–2.11), poor differentiation grade (OR = 1.79, 95% CI: 1.39–2.30), advanced tumor stage (pooled OR = 3.28, 95% CI: 2.46–4.38), lymph node metastasis (OR = 2.67, 95% CI: 1.66–4.29) and distant metastasis (OR = 4.00, 95% CI: 1.39–11.50) in cancer patients.

Conclusions:
Findings of this meta-analysis suggest that a high PVT1 expression level may serve as a novel biomarker of poor prognosis in cancers.
Incidence of dysphagia and dysphonia after Hangman's fractures
Authors: Yang Yi , Dai Lijuan , Ma Litai , Gao Xinlin , Liu Hao 
Published: December 2018

Abstract
This research aims to explore the accurate incidence, severity and outcomes of dysphagia and dysphonia after Hangman fractures.
A total of 93 patients were included in this study and clinical data were reviewed. The Bazaz grading system (0-None; 1-Mild; 2-Moderate; 3-Severe) was used for dysphagia evaluation and the Voice Handicap Index-10 used to evaluate dysphonia. In all of the patients, evaluation of dysphagia and dysphonia was performed preoperatively and at 1 week, 1 month, 3, 6, and 12 months after surgery. SPSS 22.0 software (SPSS Inc, Chicago, IL) was used for all statistical analyses.
Posttraumatic immediate dysphagia was found in 8 patients and posttraumatic immediate dysphonia was observed in 3 patients. The incidence of dysphagia was 22.6% at the 1st week, 16.1% at the 1st month, and 9.7% at the 3rd month of follow-up. The incidence of dysphonia was 24.5% at the 1st week, 11.3% at the 1st month, and 3.8% at the 3rd month of follow-up.
Posttraumatic immediate dysphagia and dysphonia occurred and the anterior surgical approach was associated with a higher incidence of dysphagia compared to posterior surgery and nonoperative patients. Most dysphagia and dysphonia were mild and gradually decreased during the subsequent 3 months after surgery. Future prospective, randomized studies with larger sample sizes are required to validate these data.
Lambda-like ST-segment elevation in acute myocardial infarction triggered by coronary spasm may be a new risk predictor for lethal ventricular arrhythmia
Authors: Wang Guangqiang , Zhao Na , Zhang Chuanhuan , Zhong Shu , Li Xuexun 
Published: December 2018

Abstract

Rationale:
The lambda-like ST-elevation electrocardiography (ECG) pattern is extremely rare in patients with type 2 myocardial infarction (T2MI) triggered by coronary spasm. When this ECG pattern appears, sudden cardiac death (SCD) caused by lethal ventricular arrhythmia may occur because clinicians do not pay sufficient attention to this phenomenon.

Patient concerns:
We describe a 41-year-old man who presented with steep down-sloping ST-segment elevation, paroxysmal ventricular tachycardia, severe sinus bradycardia, and intermittent complete atrioventricular block on ECG during the sudden recurrence of clinical symptoms.

Diagnosis:
T2MI complicated with lethal arrhythmia and caused by coronary spasm.

Interventions:
The patient received an implantable cardioverter defibrillator (ICD) for SCD caused by lethal ventricular arrhythmia and received long-term calcium-blocker and nitroglycerin therapy.

Outcomes:
At a 3-month follow-up, no recurrence was noted.

Lessons:
The lambda-like ST-elevation pattern is identified with other ST-elevation patterns by geometry and may be a new risk predictor for lethal ventricular arrhythmia on ECG. When this pattern is identified, clinicians should adopt aggressive therapeutic strategies, including ICD implantation and etiological treatment.
Myocardial calcification found in Epstein–Barr viral myocarditis and rhabdomyolysis
Authors: Sui Mingliang , Tang Weibing , Wu Changjiang 
Published: December 2018

Abstract

Rationale:
The Epstein–Barr (EB) virus has rarely been reported as a cause of fulminant myocarditis. To our knowledge, the present case is the first report on myocardial calcification in EB viral myocarditis and rhabdomyolysis.

Patient concerns:
A 17-year-old man was admitted to the department with fever, chest tightness, and tachypnea that had been present for 2 days.

Diagnoses:
The initial investigation showed elevated liver enzyme levels, creatine kinase levels, creatine kinase isoenzyme levels, and elevated serum myoglobin. Echocardiography showed that left ventricular motion amplitude decreased. Test for immunoglobin M and immunoglobin G antibodies against Epstein–Barr virus were positive. These findings were consistent with fulminant myocarditis, cardiogenic shock, and rhabdomyolysis.

Interventions:
The patient was intensively treated with venoarterial extracorporeal membrane oxygenation (VA-ECMO), continuous renal replacement therapy (CRRT).

Outcomes:
Myocardial calcification was observed in the left ventricle walls on CT examination 10 days after the admission. Four months later, the patient is still alive and with adequate daily life.

Lessons:
This case indicates that this rare form of myocardial calcification may be associated with EB viral infection and rhabdomyolysis.
Brief Report: Pre-exposure Prophylaxis Awareness and Use Among Cisgender Women at a Sexually Transmitted Disease Clinic
Authors: Raifman Julia R. , Schwartz Sheree R. , Sosnowy Collette D. , Montgomery Madeline C. , Almonte Alexi , Bazzi Angela R. , Drainoni Mari-Lynn , Stein Michael D. , Willie Tiara C. , Nunn Amy S. , Chan Philip A. 
Published: December 2018

Background:
Pre-exposure prophylaxis (PrEP) is highly effective in preventing HIV transmission. Cisgender women (cis-women) constitute only a small proportion of PrEP users in the United States despite accounting for 19% of new HIV infections in 2016.

Setting:
The Rhode Island Sexually Transmitted Diseases (STD) Clinic from 2013 to 2016.

Methods:
We report on the demographic and behavioral characteristics of all HIV-negative, cis-women who presented to the Clinic and of those who met Centers for Disease Control and Prevention (CDC) indications for PrEP. In a logistic regression analysis, we evaluated PrEP awareness among cis-women by year and demographic characteristics. We compared PrEP awareness among cis-women with PrEP awareness among cisgender men who have sex with men and among cisgender men who inject drugs presenting to the Clinic.

Results:
Among 1431 HIV-negative cis-women, 84 (5.8%) met CDC indications for PrEP. PrEP awareness was significantly lower among Hispanic/Latina cis-women [11.0%; adjusted odds ratio (AOR): 0.46, 95% confidence interval (CI): 0.31 to 0.66] and non-Hispanic black cis-women (13.8%; AOR: 0.59, 95% CI: 0.39 to 0.89) relative to non-Hispanic white cis-women (20.7%). Men who have sex with men had significantly greater PrEP awareness (60.3%; AOR: 5.85, 95% CI: 3.35 to 10.23) than cis-women (22.9%). Only one woman reported PrEP use.

Conclusions:
Two-thirds of HIV-negative cis-women presenting for HIV/sexually transmitted disease testing and meeting CDC indications for PrEP were unaware of PrEP, and only one woman reported ever using PrEP. There is a critical need for public health professionals and health care providers to increase PrEP awareness and use among cis-women at risk for HIV.
Brief Report: Malignancies in Adults Living With HIV in Asia
Authors: Jiamsakul Awachana , Polizzotto Mark , Wen-Wei Ku Stephane , Tanuma Junko , Hui Eugenie , Chaiwarith Romanee , Kiertiburanakul Sasisopin , Avihingasanon Anchalee , Yunihastuti Evy , Kumarasamy Nagalingeswaran , Ly Penh Sun , Pujari Sanjay , Ditangco Rossana , Do Cuong Duy , Merati Tuti Parwati , Kantipong Pacharee , Zhang Fujie , Van Nguyen Kinh , Kamarulzaman Adeeba , Choi Jun Yong , Sim Benedict L.H. , Ng Oon Tek , Ross Jeremy , Wong Wingwai ,   on behalf of the TREAT Asia HIV Observational Database of IeDEA Asia-Pacific
Published: December 2018

Background:Hematological malignancies have continued to be highly prevalent among people living with HIV (PLHIV). This study assessed the occurrence of, risk factors for, and outcomes of hematological and nonhematological malignancies in PLHIV in Asia.Methods:Incidence of malignancy after cohort enrollment was evaluated. Factors associated with development of hematological and nonhematological malignancy were analyzed using competing risk regression and survival time using Kaplan–Meier.Results:Of 7455 patients, 107 patients (1%) developed a malignancy: 34 (0.5%) hematological [0.08 per 100 person-years (/100PY)] and 73 (1%) nonhematological (0.17/100PY). Of the hematological malignancies, non-Hodgkin lymphoma was predominant (n = 26, 76%): immunoblastic (n = 6, 18%), Burkitt (n = 5, 15%), diffuse large B-cell (n = 5, 15%), and unspecified (n = 10, 30%). Others include central nervous system lymphoma (n = 7, 21%) and myelodysplastic syndrome (n = 1, 3%). Nonhematological malignancies were mostly Kaposi sarcoma (n = 12, 16%) and cervical cancer (n = 10, 14%). Risk factors for hematological malignancy included age >50 vs. ≤30 years [subhazard ratio (SHR) = 6.48, 95% confidence interval (CI): 1.79 to 23.43] and being from a high-income vs. a lower-middle-income country (SHR = 3.97, 95% CI: 1.45 to 10.84). Risk was reduced with CD4 351–500 cells/µL (SHR = 0.20, 95% CI: 0.05 to 0.74) and CD4 >500 cells/µL (SHR = 0.14, 95% CI: 0.04 to 0.78), compared to CD4 ≤200 cells/µL. Similar risk factors were seen for nonhematological malignancy, with prior AIDS diagnosis showing a weak association. Patients diagnosed with a hematological malignancy had shorter survival time compared to patients diagnosed with a nonhematological malignancy.Conclusions:Nonhematological malignancies were common but non-Hodgkin lymphoma was more predominant in our cohort. PLHIV from high-income countries were more likely to be diagnosed, indicating a potential underdiagnosis of cancer in low-income settings.
Novel Use of Responsive Neurostimulation (RNS System) in the Treatment of Super Refractory Status Epilepticus
Authors: Ernst Lia D. , Krause Katie L. , Kellogg Marissa A. , Raslan Ahmed M. , Spencer David C. 
Published: December 2018

Summary:
There are very few randomized controlled trials studying treatment of super refractory status epilepticus (SE), despite estimated occurrence in about 15% of SE cases and its association with high morbidity and mortality rates. Small case series and case reports have described use of neurostimulation, including vagal nerve stimulation, transcranial magnetic stimulation, and deep brain stimulation, to treat super refractory SE when medical interventions have failed. To our knowledge, this is the first reported case of responsive neurostimulation being used to successfully treat a case of super refractory SE. A 37-year-old man with refractory focal epilepsy and a known focal cortical dysplasia involving motor cortex was implanted with an RNS System device after being in super refractory SE for 20 days. Responsive neurostimulation strip and depth electrodes were placed targeting the cortical dysplasia. Detection and stimulation parameters were adjusted over a 14-day period, as medications were gradually weaned. Seizures abated 15 days after implant, 24 hours after stimulation parameters were configured to mimic seizure offset pattern. Seizure remission was sustained, allowing the patient to be weaned off sedating medications and discharged to a rehabilitation facility. At 6 weeks of follow-up, the patient was near his neurologic baseline with no focal deficits.
Where Do Women With Urinary Incontinence Find Information About Absorbent Products and How Useful Do They Find It?
Authors: Smith Nicholas , Hunter Kathleen F. , Rajabali Saima , Milsom Ian , Wagg Adrian 
Published: December 2018

PURPOSE:
This study aimed to determine from what sources women with urinary and dual urinary and fecal incontinence sought and received information about incontinence and absorbent products. We also evaluated source utility.

DESIGN:
Descriptive, embedded, mixed-methods study with qualitative interviews nested into a survey design in a modified explanatory sequence.

SUBJECTS AND SETTING:
The target population was community-dwelling women in Canada who used containment products to manage urinary incontinence. Three hundred fifteen women completed the online survey, and 9 participated in interviews.

METHOD:
Quantitative data were collected using an online survey that was advertised in multiple locations, including continence and urogynecology clinics, non-for-profit health Web sites, and social media. Descriptive statistics were used for analysis. Using initial quantitative data results, a semistructured interview guide was designed to gain further insight. Local survey participants were invited to interviews at the end of the survey. Interview transcripts were coded using content analysis. The codes were then collapsed into categories and finally themes.

RESULTS:
The most common sources of information (n = 284/315) were retail outlets (43%) and television/radio (42%). The greatest percentages of “useful” or “very useful” resources were healthcare professionals (83%). Content analysis identified 5 themes: (1) using existing knowledge, (2) seeking knowledge, (3) finding the right pad, (4) being safe and secure, and (5) perceptions of healthcare professionals' roles. Product choice was made through trial and error; women drew information from a variety of sources, including product labels. Perceptions of helpfulness of experiences with healthcare professionals varied.

CONCLUSION:
Although women used multiple sources when selecting containment products, they did not receive information in a manner that suited their needs, resulting in a trial-and-error approach to product selection. Healthcare professionals should actively give information on containment products during their assessment of continence in patient encounters.
PGC1α and Exercise Adaptations in Zebrafish
Authors: Parisi Alice , Blattmann Peter , Lizzo Giulia , Stutz Vivienne , Strohm Laura , Richard Joy , Civiletto Gabriele , Charpagne Aline , Raymond Frederic , Gobet Cedric , Weger Benjamin , Migliavacca Eugenia , Aebersold Ruedi , Spiegelman Bruce , Gut Philipp 
Published: December 2018

ABSTRACTFish species display huge differences in physical activity ranging from lethargy to migration of thousands of miles, making them an interesting model to identify determinants of physical fitness. Here, we show a remarkable plasticity of zebrafish in response to exercise and induction of PGC1α (encoded byPPARGC1A), a dominant regulator of mitochondrial biogenesis. Forced expression of humanPPARGC1Ainduces mitochondrial biogenesis, an exercise-like gene expression signature, and physical fitness comparable to wild-type animals trained in counter-current swim tunnels. Quantifying transcriptional and proteomic changes in response to exercise or PGC1α, we identify conserved ‘exercise’ adaptations, including a stoichiometric induction of the electron transport chain (ETC) that re-organizes into respiratory supercomplexes in both conditions. We further show that ndufa4/ndufa4l, previously assigned to complex I, associates to free and supramolecular complex IVin vivo. Thus, zebrafish is a useful and experimentally tractable vertebrate model to study exercise biology, including ETC expression and assembly.HIGHLIGHTSPGC1α reprograms zebrafish skeletal muscle to a ‘red fiber’ phenotype and increases exercise performanceZebrafish show a high molecular plasticity in response to PGC1α and exerciseSWATH-MS proteomics show a stoichiometric induction of the electron transport chain that organizes as supercomplexes in response to PGC1α and exercisendufa4/ndufa4l associate to free and supramolecular complex IVin vivo
Who is researching biodiversity hotspots in Eastern Europe? A case study on grasslands from Romania
Authors: Nita Andreea , Hartel Tibor , Manolache Steluta , Ciocanea Cristiana M. , Miu Iulia V. , Rozylowicz Laurentiu 
Published: December 2018

AbstractFarming landscapes of Europe are vital arenas for social-ecological sustainability because of their significant coverage and potential to integrate food production with biodiversity conservation. Knowledge gathered by scientific research is a critical ingredient for developing and implementing socio-economically and ecologically sustainable grassland management strategies for grasslands. The quality of scientific knowledge and its potential to address grasslands as complex social-ecological systems is strongly dependent on the creativity and scientific ambition of the researcher, but also on the network (from academic and non-academic sectors) around the researcher. The goal of this paper is to map the research network around Romania’s grasslands. These systems have exceptional socio-cultural and economic values and are between the most biodiverse ecosystems of the world. Considering the multiple threats to these grasslands, it is an urgent need to understand the existing scientific knowledge profile around these systems. This paper aims at using bibliometrics analysis, a well-developed scientific domain that envisages network theory to analyze relationships between affiliations network, co-authorship network, and co-word analysis. The number of studies targeting grassland management in Romania is increasing mainly thanks to international involvement. However, the management of the grasslands is still deficient and the contribution of science to the process is virtually absent. The subject of research is mainly related to the biological and ecological characteristics of grasslands, a notable absence from internationally visible research being the management of grasslands, especially in the context of EU Common Agricultural Policies. To increase scientific performance, and better inform EU and local policies on grassland management, Romanian researchers should better capitalize on international collaborations and local academic leaders. Our findings can be used to identify research gaps and to improve collaboration and knowledge exchange between practitioners, scientists, policy makers, and stakeholders.