bluuebunny/crossref_metadata_2025_split huggingface dataset:
The liver flukeOpisthorchis felineusas a group III or group I carcinogen
Authors: Pakharukova Mariya Yurievna , Correia da Costa José Manuel , Mordvinov Viatcheslav Alekseevitch 
Published: July 2019

Opisthorchiasis caused by the liver flukeOpisthorchis felineusis one of the most common helminthic infections in the Russian Federation. The largest area affected by opisthorchiasis felinea occupies almost the entire territory of Western Siberia and extends to northern Kazakhstan and a part of the Ural region. Natural endemic regions of opisthorchiasis also exist in the European part of Russia, and in the regions of Western and Eastern Europe. According to the official statistics of the Russian Federation, up to 40 000 patients with opisthorchiasis are registered annually in the country.Opisthorchiasis felinea affects the hepatobiliary system and causes serious liver disorders, including cancer of the biliary tract. Other parasitoses, opisthorchiasis viverrini and clonorchiasis, are widespread in the Southeast Asia and China. The causative agents of these diseases, liver flukesO. viverriniandClonorchis sinensis, are officially recognized as Group 1 biological carcinogens and are classified as the main risk factors for cholangiocarcinoma.O. felineusis included in Group 3 of biological carcinogens and is not officially considered carcinogenic to humans. Studies on the carcinogenic potential of this liver fluke and the epidemiology of cholangiocarcinoma in the Russian Federation have started in earnest quite recently. Nevertheless, we have some evidence that infection withO. felineusleads to a precancerous state of the bile duct epithelium. This state, combined with additional risk factors, poses a real risk of cholangiocarcinoma. In our opinion, taking into consideration the accumulated facts, the classification of the carcinogenic potential ofO. felineusrequires revision. In this review, we focus on the relevant characteristics of the biology and epidemiology of this helminth as well as experimental data on opisthorchiasis felinea; this information might clarify the carcinogenicity ofO. felineusto humans.
Substitution Opiatabhängiger im Rahmen der stationären Rehabilitationsbehandlung – welche Patienten profitieren?
Authors: Kuhlmann Thomas , Specka Michael , Rhode Andreas , Post Yvonne , Pietras Martina , Funke Wilma , Feugmann Karin , Scherbaum Norbert 
Published: July 2019

Zusammenfassung
Ziel Es wird untersucht, ob opiatabhängige Patienten mit gesundheitlichen und sozialen Zusatzbelastungen von einer stationären Drogen-Reha davon profitieren, dass eine bestehende Substitution zunächst fortgeführt wird.
Methodik Multizentrische Studie in 4 Fachkliniken mit 227 bei Aufnahme substituierten und 156 bei Aufnahme opioidfreien Patienten.
Ergebnisse Patienten ohne Reha-Erfahrung und solche mit affektiven und Angststörungen zeigten in der abstinenzbasierten Behandlung geminderte Erfolgsraten, in der initial substituierten Gruppe dagegen erhöhte.
Schlussfolgerung Für Patienten mit besonderen psychischen Belastungen bzw. für solche, die rein abstinenzbasierte Rehabilitationsbehandlungen nicht beginnen wollten, kann die Aufnahme unter Substitution ein Vorteil sein.
Midterm Results after Implant-Free Patellar Fixation Technique for Medial Patellofemoral Ligament Reconstruction
Authors: Mayer Philipp , Schuster Philipp , Schlumberger Michael , Eichinger Martin , Pfaff Michael , Immendörfer Micha , Richter Jörg 
Published: July 2019

AbstractProblems and complications concerning the patellar fixation in medial patellofemoral ligament reconstruction (MPFLR) have been reported. The purpose of this retrospective study was to systematically analyze the surgical technique for MPFLR with a V-shaped patellar bonetunnel for implant-free fixation of an autologous gracilis tendon, allowing early functional rehabilitation, regarding restoration of the patellofemoral stability, patient satisfaction, return to sports, and technique-specific complications. In 2010, 128 cases of consecutive isolated MPFLR were performed. All these cases were included. After a minimum follow-up of 3 years, 104 cases were retrospectively analyzed (follow-up: 81.3%) with regard to redislocation, subjective functional outcome (Tegner's score and sports level compared with preoperative level), patient satisfaction, revision surgery, and technique-specific complications. After a follow-up of 45.7 ± 3.2 months, 101 of 104 cases (97.1%) showed no redislocation. Mean Tegner's score was 5.1 ± 1.8 (range, 2–9). A total of 61.5% patients reported about a higher sports level compared with their preoperative level. The patient satisfaction was high with 94.2%. In two cases (1.9%), technique-specific problems occurred as the bone bridge of the V-shaped tunnel was insufficient due to a malpositioning of the aiming device. No further technique-specific problems occurred and no revision surgery was necessary during the observational period. The presented surgical technique is safe and it reliably restores the patellofemoral stability, with a low rate of redislocations, an excellent subjective functional outcome, and a high-patient-reported satisfaction. No major technique-specific complications occurred.
Antigen structure affects cellular routing through DC-SIGN
Authors: Jarvis Cassie M. , Zwick Daniel B. , Grim Joseph C. , Alam Mohammad Murshid , Prost Lynne R. , Gardiner Jaye C. , Park Soyeong , Zimdars Laraine L. , Sherer Nathan M. , Kiessling Laura L. 
Published: July 2019

SignificanceDendritic cells (DCs) express cell-surface lectins that bind to carbohydrates displayed on the surface of pathogens. The binding of pathogens to these lectins results in internalization to endosomal compartments, where the pathogens are destroyed and an immune response is initiated. HIV-1 can subvert this process—lectin engagement routes HIV-1 to cellular compartments that allow the virus to evade destruction. We synthesized glycopolymers to test whether the size and physical properties of the antigens impact trafficking. Small polymers trafficked to endosomes, as expected. Alternatively, large particulate polymers localized in the nonendosomal compartments occupied by HIV-1. These data indicate that antigen structure affects routing by DC lectins. Our findings can be exploited to direct cargo to different compartments.
α-synuclein−lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients
Authors: Paslawski Wojciech , Zareba-Paslawska Justyna , Zhang Xiaoqun , Hölzl Katharina , Wadensten Henrik , Shariatgorji Mohammadreza , Janelidze Shorena , Hansson Oskar , Forsgren Lars , Andrén Per E. , Svenningsson Per 
Published: July 2019

Significance
Two of the most important issues in Parkinson’s disease (PD) research are the identification of mechanisms underlying α-synuclein cell-to-cell transfer in the nervous system and the discovery of early diagnostic biomarkers. Both of these issues are addressed in our current manuscript. Using multiple approaches, we present that α-synuclein interacts with lipoproteins within human cerebrospinal fluid and can be taken up by cells in such a state. Moreover, using cerebrospinal fluid samples from 3 large and independent cohorts of patients, we demonstrate that apolipoprotein E is elevated in early, not yet medicated, patients with PD. Finally, using postmortem brain tissue, we provide preliminary histological evidence that apolipoprotein E is enriched in a subpopulation of dopaminergic neurons of human substantia nigra.
The 2019 surface acoustic waves roadmap
Authors: Delsing Per , Cleland Andrew N , Schuetz Martin J A , Knörzer Johannes , Giedke Géza , Cirac J Ignacio , Srinivasan Kartik , Wu Marcelo , Balram Krishna Coimbatore , Bäuerle Christopher , Meunier Tristan , Ford Christopher J B , Santos Paulo V , Cerda-Méndez Edgar , Wang Hailin , Krenner Hubert J , Nysten Emeline D S , Weiß Matthias , Nash Geoff R , Thevenard Laura , Gourdon Catherine , Rovillain Pauline , Marangolo Max , Duquesne Jean-Yves , Fischerauer Gerhard , Ruile Werner , Reiner Alexander , Paschke Ben , Denysenko Dmytro , Volkmer Dirk , Wixforth Achim , Bruus Henrik , Wiklund Martin , Reboud Julien , Cooper Jonathan M , Fu YongQing , Brugger Manuel S , Rehfeldt Florian , Westerhausen Christoph 
Published: July 2019

Abstract
Today, surface acoustic waves (SAWs) and bulk acoustic waves are already two of the very few phononic technologies of industrial relevance and can been found in a myriad of devices employing these nanoscale earthquakes on a chip. Acoustic radio frequency filters, for instance, are integral parts of wireless devices. SAWs in particular find applications in life sciences and microfluidics for sensing and mixing of tiny amounts of liquids. In addition to this continuously growing number of applications, SAWs are ideally suited to probe and control elementary excitations in condensed matter at the limit of single quantum excitations. Even collective excitations, classical or quantum are nowadays coherently interfaced by SAWs.
This wide, highly diverse, interdisciplinary and continuously expanding spectrum literally unites advanced sensing and manipulation applications. Remarkably, SAW technology is inherently multiscale and spans from single atomic or nanoscopic units up even to the millimeter scale.
The aim of this Roadmap is to present a snapshot of the present state of surface acoustic wave science and technology in 2019 and provide an opinion on the challenges and opportunities that the future holds from a group of renown experts, covering the interdisciplinary key areas, ranging from fundamental quantum effects to practical applications of acoustic devices in life science.
Superconducting qubit circuit emulation of a vector spin-1/2
Authors: Kerman Andrew J 
Published: July 2019

Abstract
We propose a superconducting qubit that fully emulates a quantum spin-1/2, with an effective vector dipole moment whose three components obey the commutation relations of an angular momentum in the computational subspace. Each of these components of the dipole moment also couples approximately linearly to an independently-controllable external bias, emulating the linear Zeeman effect due to a fictitious, vector magnetic field over a broad range of effective total fields around zero. This capability, combined with established techniques for qubit coupling, should enable for the first time the direct, controllable hardware emulation of nearly arbitrary, interacting quantum spin-1/2 systems, including the canonical Heisenberg model. Furthermore, it constitutes a crucial step both towards realizing the full potential of quantum annealing, as well as exploring important quantum information processing capabilities that have so far been inaccessible to available hardware, such as quantum error suppression, Hamiltonian and holonomic quantum computing, and adiabatic quantum chemistry.
Energy harvesting using thermoelectricity for IoT (Internet of Things) and E-skin sensors
Authors: Park Hwanjoo , Lee Dongkeon , Park Gimin , Park Sungjin , Khan Salman , Kim Jiyong , Kim Woochul 
Published: July 2019

Abstract
With the increasing demand for Internet of Things (IoT) with integrated wireless sensor networks (WSNs), sustainable power supply and management have become important issues to be addressed. Thermal energy in forms of waste heat or metabolic heat is a promising source for reliably supplying power to electronic devices; for instance, thermoelectric power generators are widely being researched as they are able to convert thermal energy into electricity. This paper specifically looks over the application of thermoelectricity as a sustainable power source for IoT including WSNs. Also, we discuss a few thermoelectric systems capable of operating electronic skin (e-skin) sensors despite their low output power from body heat. For a more accurate analysis on body heat harvesting, models of the human thermoregulatory system have been investigated. In addition, some clever designs of heat sinks that can be integrated with thermoelectric systems have also been introduced. For their power management, the integration with a DC–DC converter is addressed to boost its low output voltage to a more usable level.
Effectiveness of a community-based self-care promoting program for community-dwelling older adults: a randomized controlled trial
Authors: Wong Arkers Kwan Ching , Wong Frances Kam Yuet , Chang Katherine 
Published: July 2019

AbstractBackgroundThe existing health care system tends to be focused on acute diseases or patients with high levels of need and is not ideal for meeting the challenges of an ageing population. This study introduced a community-based self-care promoting program for community-dwelling older adults, and tested its effects on maintaining health.ObjectivesTo determine whether the program can increase self-efficacy, quality of life (QoL), basic and instrumental activities of daily living, and medication adherence, while reducing health service utilization for community-dwelling older adults.MethodsResearchers randomly assigned 457 older adults to receive the intervention (n = 230) or be controls (n = 227). The intervention included assessment and education of self-care and health-promoting behaviors, co-produced care planning and self-efficacy enhancing components supported by a health-social partnership. The control group received placebo social calls. The outcomes were measured at pre-intervention (T1) and three months post-intervention (T2).ResultsAnalysis showed that the intervention group had a significantly higher score in self-efficacy (P = 0.049), activities of daily living (ADL) (P = 0.012), instrumental activities of daily living (IADL) (P = 0.021) and the physical components of QoL (P < 0.001) at T2 than at T1. The program also significantly improved the mental component of QoL (P < 0.001) and medication adherence (P < 0.001), as well as reducing the total number of health service attendances compared to the control group (P = 0.016).ConclusionThe program can help enhance the self-efficacy of community-dwelling older adults towards self-care, which may in turn enable them to maintain optimal well-being while remaining in the community.
Anticorruption as Transnational Law: The Foreign Corrupt Practices Act, PRC Law, and Party Rules in China
Authors: Erie Matthew S 
Published: July 2019

Abstract
Corruption has been linked to urgent transnational problems, including, inter alia, market uncertainties, the undermining of democracy, economic disparity, religious extremism, and authoritarianism. As corruption is a global problem, it requires coordination across states’ anticorruption laws. Anticorruption thus provides grounds to reassess the promise and limits of transnational law. This Article examines the operation of anticorruption as transnational law across the corporate governance regimes of the United States and China, the world’s two largest economies. As opposed to perceptions that Washington and Beijing are engaged in a zero-sum game, anticorruption is a policy concern against which both states may rally. Inter-regulatory coordination is far from a frictionless process, however. Cross-border lawyers working on both sides of the Pacific engaged in anticorruption law are a type of transnational community and highlight these tensions. Lawyers apply standards in the 1977 U.S. Foreign Corrupt Practices Act, the People’s Republic of China antibribery laws, and internal Chinese Communist Party rules to ensure their clients comply with multiple regimes. Ethnographic data shows that lawyers assess different regulatory environments, in this case, one of extraterritorial jurisdiction and the other characterized by a political campaign, in the course of advising multinational companies. The Article argues that lawyers’ roles are a lynchpin of these overlapping systems of compliance as their work operates to discipline corporations in China; nonetheless, lawyers’ position in the global legal market impacts what they deem to be “corrupt” and which rules apply. A focus on cross-border lawyers as transnational communities thus marries legal analysis with a contextual grounding in lawyers’ work, an approach that has merit for the study of comparative law more generally. The Article finds that given market pressures, in the area of anticorruption, trends show a preference for “bicultural lawyers,” those who are both embedded within transnational communities and respond to demands in the global market.
Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder?
Authors: Tunstall Brendan J , Lorrai Irene , McConnell Sam A , Gazo Katrina L , Zallar Lia J , de Guglielmo Giordano , Hoang Ivy , Haass-Koffler Carolina L , Repunte-Canonigo Vez , Koob George F , Vendruscolo Leandro F , Sanna Pietro Paolo 
Published: July 2019

Abstract

Aims
The development of novel and more effective medications for alcohol use disorder (AUD) is an important unmet medical need. Drug repositioning or repurposing is an appealing strategy to bring new therapies to the clinic because it greatly reduces the overall costs of drug development and expedites the availability of treatments to those who need them. Probenecid, p-(di-n-propylsulfamyl)-benzoic acid, is a drug used clinically to treat hyperuricemia and gout due to its activity as an inhibitor of the kidneys’ organic anion transporter that reclaims uric acid from urine. Probenecid also inhibits pannexin1 channels that are involved in purinergic neurotransmission and inflammation, which have been implicated in alcohol’s effects and motivation for alcohol. Therefore, we tested the effects of probenecid on alcohol intake in rodents.

Methods
We tested the effects of probenecid on operant oral alcohol self-administration in alcohol-dependent rats during acute withdrawal as well as in nondependent rats and in the drinking-in-the-dark (DID) paradigm of binge-like drinking in mice.

Results
Probenecid reduced alcohol intake in both dependent and nondependent rats and in the DID paradigm in mice without affecting water or saccharin intake, indicating that probenecid’s effect was selective for alcohol and not the result of a general reduction in reward.

Conclusions
These results raise the possibility that pannexin1 is a novel therapeutic target for the treatment of AUD. The clinical use of probenecid has been found to be generally safe, suggesting that it can be a candidate for drug repositioning for the treatment of AUD.
Ventral scale width in snakes depends on habitat but not hunting strategy
Authors: Bury Stanisław , Borczyk Bartosz , Skawiński Tomasz 
Published: July 2019

Abstract
Environment and lifestyle induce substantial variation in the mechanisms of locomotion in vertebrates. A spectrum of adaptations related to locomotion is also present in limbless taxa, especially snakes, which have radiated successfully into a wide range of habitats. The majority of studies concerning habitat-driven variation in locomotor mechanisms of snakes have focused on the musculoskeletal system. Far less recognized is the variation in the morphology of ventral scales, which are another pivotal component of the locomotor system in snakes. Here, we investigated patterns of interspecific variation in the width of ventral scales in terms of lifestyle (hunting mode) and habitat occupied in 55 species of snakes belonging to eight families. We found that increasing terrestriality was associated with enlarged ventral scales. Reduction instead of maintenance of the width of ventral scales was observed in aquatic species, suggesting that wide ventral scales set constraints on aquatic locomotion. In terrestrial species, no significant differences were observed in terms of arboreality or hunting mode, which suggests overall optimization in the size of ventral scales towards terrestrial locomotion. Association between the width of ventral scales and locomotion can result in a habitat-dependent costs of abnormalities in ventral scale morphology, commonly observed in snakes.
Cerebellar Gray Matter and Olfactory Performance
Authors: Wabnegger Albert , Schienle Anne 
Published: July 2019

AbstractThe role of the cerebellum in the chemical senses is still poorly understood. This voxel-based morphometry (VBM) study investigated associations between gray matter volume (GMV) in subregions of the cerebellum and olfactory performance. VBM data from 48 men were analyzed. The participants were tested with a standardized olfactory test that measured olfactory threshold, discrimination, and identification ability. The investigated sample covered a wide range of olfactory performance, including individuals with a reduced sense of smell (anosmia and hyposmia) and normosmia. The computed regression analyses revealed a positive association between olfactory identification performance and GMV in lobule VI. This cerebellar subregion is involved in higher-order cognitive functions (language and memory), which are necessary prerequisites for correct odor labeling. Odor detection and discrimination were unrelated to cerebellar GMV.
Pandemic Uropathogenic Fluoroquinolone-resistant Escherichia coli Have Enhanced Ability to Persist in the Gut and Cause Bacteriuria in Healthy Women
Authors: Tchesnokova Veronika L , Rechkina Elena , Chan Diana , Haile Helen Ghirmai , Larson Lydia , Ferrier Kendra , Schroeder David W , Solyanik Thalia , Shibuya Spencer , Hansen Kelly , Ralston James D , Riddell Kim , Scholes Delia , Sokurenko Evgeni V 
Published: July 2019

Abstract
We report that fluoroquinolone-resistant Escherichia coli are found in feces of 8.8% of healthy women, with most bacteria belonging to pandemic multidrug-resistant ST131-H30R or ST1193 clonal groups. Moreover, these highly uropathogenic clonal groups demonstrate an especially prolonged gut persistence and high rate of bacteriuria without documented urinary tract infection.
The Emotional Toll of Inflammatory Bowel Disease: Using Machine Learning to Analyze Online Community Forum Discourse
Authors: Lerrigo Robert , Coffey Johnny T R , Kravitz Joshua L , Jadhav Priyanka , Nikfarjam Azadeh , Shah Nigam H , Jurafsky Dan , Sinha Sidhartha R 
Published: July 2019

AbstractBackgroundPatients with inflammatory bowel disease are using online community forums (OCFs) to seek emotional support. The impact of OCFs on well-being and their emotional content are unknown.MethodsWe used an unsupervised machine learning algorithm to identify the thematic content of 51,591 public, online posts from the Crohn’s & Colitis Foundation Community Forum.ResultsWe identified 10,702 (20.8%) posts expressing: gratitude (40%), anxiety/fear (20.8%), empathy (18.2%), anger/frustration (13.4%), hope (13.2%), happiness (10.0%), sadness/depression (5.8%), shame/guilt (2.5%), and/or loneliness (2.5%). A common subtheme was the importance of fostering social support.ConclusionsHigh-throughput, machine learning-directed analysis of OCFs may help identify psychosocial impacts of inflammatory bowel disease on patients and their caregivers.