bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary prostatic extragastrointestinal stromal tumor: a case report and literature review
Authors: You Yong-hao , Zhang Yi 
Published: August 2018

Objective This study was performed to discuss the characteristics, diagnosis, and treatment of primary prostatic extragastrointestinal stromal tumor (EGIST). Methods The case history data of a patient with an EGIST were analyzed and discussed with a literature review. Results The patient was diagnosed with a pelvic tumor, possibly malignant. We ascertained the diagnosis by exploratory surgery and pathological biopsy. The tumor was present in the prostate and infiltrated and pressed against the anterior rectal wall. Pathological biopsy showed that the tumor comprised spindle cells, which were also present at the junction of the tumor and prostate tissue. Immunohistochemically, the tumor cells were positive for CD117, DOG-1, CD34, and smooth muscle actin and negative for S100 and desmin; Ki-67LI was about 10%. These results support the diagnosis of primary prostatic EGIST. Conclusion The rarity and nonspecific clinical manifestation of prostatic EGIST facilitate misdiagnosis. Diagnosis mainly depends on imaging examination and characteristic histopathological and immunohistochemical features, and GIST must be excluded. Surgery is the main treatment method, and imatinib is suggested for unresectable and malignant EGISTs.
Pathogenic Factors Associated With Osgood-Schlatter Disease in Adolescent Male Soccer Players: A Prospective Cohort Study
Authors: Watanabe Hiroyuki , Fujii Meguru , Yoshimoto Masumi , Abe Hiroshi , Toda Naruaki , Higashiyama Reiji , Takahira Naonobu 
Published: August 2018

Background: A previous cross-sectional study reported that pathogenic factors associated with Osgood-Schlatter disease (OSD) in adolescent athletes include increased quadriceps muscle tightness, lower leg malalignment, and development of apophysitis in the tibial tuberosity. Purpose: To confirm these pathogenic factors associated with OSD in a longitudinal study with regard to physical function and performance. Study Design: Cohort study; Level of evidence, 2. Methods: In this study, 37 boys (mean age, 10.2 ± 0.4 years) were recruited from 2 soccer teams at an elementary school. This cohort study was conducted over an observation period of 1 year, with measurements recorded at baseline, followed by screening for OSD every 6 months. Variables evaluated at baseline included physical function (morphometry, joint flexibility, and lower extremity alignment), presence of Sever disease, and kicking motion. Results: Pathogenic factors associated with OSD in the support leg of adolescent male soccer players included height, weight, body mass index, quadriceps femoris muscle tightness in the kicking and support legs, and gastrocnemius muscle tightness, soleus muscle tightness, and medial longitudinal arch in the support leg. Additional factors included a diagnosis of Sever disease and distance from the lateral malleolus of the support leg’s fibula to the center of gravity during kicking. Conclusion: The onset of OSD was found to be affected by many factors, including developmental stage, physical attributes, and pre-existing apophysitis. In particular, a diagnosis of Sever disease and backward shifting of the center of gravity during kicking increased the risk of the subsequent onset of OSD, suggesting that these factors are very important as a possible focus for interventions.
Long-term disease control of Langerhans cell histiocytosis using combined BRAF and MEK inhibition
Authors: Awada Gil , Seremet Teofila , Fostier Karel , Everaert Hendrik , Neyns Bart 
Published: August 2018

Key Points
Treatment with a BRAF and MEK inhibitor can achieve a sustained response in BRAFV600-mutant Langerhans cell histiocytosis. Detection of plasma BRAFV600-mutant circulating tumor DNA is a promising biomarker for monitoring disease activity in this entity.
CNS Response to Osimertinib Versus Standard Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer
Authors: Reungwetwattana Thanyanan , Nakagawa Kazuhiko , Cho Byoung Chul , Cobo Manuel , Cho Eun Kyung , Bertolini Alessandro , Bohnet Sabine , Zhou Caicun , Lee Ki Hyeong , Nogami Naoyuki , Okamoto Isamu , Leighl Natasha , Hodge Rachel , McKeown Astrid , Brown Andrew P. , Rukazenkov Yuri , Ramalingam Suresh S. , Vansteenkiste Johan 
Published: August 2018

Purpose We report CNS efficacy of osimertinib versus standard epidermal growth factor receptor ( EGFR) tyrosine kinase inhibitors (TKIs) in patients with untreated EGFR-mutated advanced non–small-cell lung cancer from the phase III FLAURA study. Patients and Methods Patients (N = 556) were randomly assigned to osimertinib or standard EGFR-TKIs (gefitinib or erlotinib); brain scans were not mandated unless clinically indicated. Patients with asymptomatic or stable CNS metastases were included. In patients with symptomatic CNS metastases, neurologic status was required to be stable for ≥ 2 weeks after completion of definitive therapy and corticosteroids. A preplanned subgroup analysis with CNS progression-free survival as primary objective was conducted in patients with measurable and/or nonmeasurable CNS lesions on baseline brain scan by blinded independent central neuroradiologic review. The CNS evaluable-for-response set included patients with ≥ one measurable CNS lesion. Results Of 200 patients with available brain scans at baseline, 128 (osimertinib, n = 61; standard EGFR-TKIs, n = 67) had measurable and/or nonmeasurable CNS lesions, including 41 patients (osimertinib, n = 22; standard EGFR-TKIs, n = 19) with ≥ one measurable CNS lesion. Median CNS progression-free survival in patients with measurable and/or nonmeasurable CNS lesions was not reached with osimertinib (95% CI, 16.5 months to not calculable) and 13.9 months (95% CI, 8.3 months to not calculable) with standard EGFR-TKIs (hazard ratio, 0.48; 95% CI, 0.26 to 0.86; P = .014 [nominally statistically significant]). CNS objective response rates were 91% and 68% in patients with ≥ one measurable CNS lesion (odds ratio, 4.6; 95% CI, 0.9 to 34.9; P = .066) and 66% and 43% in patients with measurable and/or nonmeasurable CNS lesions (odds ratio, 2.5; 95% CI, 1.2 to 5.2; P = .011) treated with osimertinib and standard EGFR-TKIs, respectively. Probability of experiencing a CNS progression event was consistently lower with osimertinib versus standard EGFR-TKIs. Conclusion Osimertinib has CNS efficacy in patients with untreated EGFR-mutated non–small-cell lung cancer. These results suggest a reduced risk of CNS progression with osimertinib versus standard EGFR-TKIs.
Hydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features
Authors: Godfrey Anna L. , Campbell Peter J. , MacLean Cathy , Buck Georgina , Cook Julia , Temple Julie , Wilkins Bridget S. , Wheatley Keith , Nangalia Jyoti , Grinfeld Jacob , McMullin Mary Frances , Forsyth Cecily , Kiladjian Jean-Jacques , Green Anthony R. , Harrison Claire N. ,   on behalf of the United Kingdom Medical Research Council Primary Thrombocythemia-1 Study,   the United Kingdom National Cancer Research Institute Myeloproliferative Neoplasms Subgroup,   the French Intergroup of Myeloproliferative Neoplasms,   and the Australasian Leukaemia and Lymphoma Group.
Published: August 2018

Purpose Cytoreductive therapy is beneficial in patients with essential thrombocythemia (ET) at high risk of thrombosis. However, its value in those lacking high-risk features remains unknown. This open-label, randomized trial compared hydroxycarbamide plus aspirin with aspirin alone in patients with ET age 40 to 59 years and without high-risk factors or extreme thrombocytosis. Patients and Methods Patients were age 40 to 59 years and lacked a history of ischemia, thrombosis, embolism, hemorrhage, extreme thrombocytosis (platelet count ≥ 1,500 × 109/L), hypertension, or diabetes requiring therapy. In all, 382 patients were randomly assigned 1:1 to hydroxycarbamide plus aspirin or aspirin alone. The composite primary end point was time to arterial or venous thrombosis, serious hemorrhage, or death from vascular causes. Secondary end points were time to first arterial or venous thrombosis, first serious hemorrhage, death, incidence of transformation, and patient-reported quality of life. Results After a median follow-up of 73 months and a total follow-up of 2,373 patient-years, there was no significant difference between the arms in the likelihood of patients reaching the primary end point (hazard ratio, 0.98; 95% CI, 0.42 to 2.25; P = 1.0). The incidence of significant vascular events was low, at 0.93 per 100 patient-years (95% CI, 0.61 to 1.41). There were also no differences in overall survival; in the composite end point of transformation to myelofibrosis, acute myeloid leukemia, or myelodysplasia; in adverse events; or in patient-reported quality of life. Conclusion In patients with ET age 40 to 59 years and lacking high-risk factors for thrombosis or extreme thrombocytosis, preemptive addition of hydroxycarbamide to aspirin did not reduce vascular events, myelofibrotic transformation, or leukemic transformation. Patients age 40 to 59 years without other clinical indications for treatment (such as previous thrombosis or hemorrhage) who have a platelet count < 1,500 × 109/L should not receive cytoreductive therapy.
“Greater Still in Death”: Race, Martyrology, and the Reanimation of Juan Placido
Authors: Boutelle R. J. 
Published: August 2018

AbstractThis article details how John Greenleaf Whittier accidentally assumed two different Cuban poets of color (Juan Francisco Manzano and Plácido) were one and the same person, resulting in an unwittingly combinatory sketch of “Juan Placido.” The resulting syncretic personage in Whittier’s “The Black Man” (1845) became a cause célèbre for abolitionists. I argue that to effectively persuade his white Northern audience, Whittier rewrote his source texts into the sentimental registers of moral suasion and culturally decontextualized Juan Placido, transforming the “Cuban martyr poet” into a transnational race man. In the essay’s second half, I demonstrate how Martin R. Delany’s Blake (1859, 1861–62) readapted Whittier’s account to appeal to black radical abolitionists. By literarily resurrecting Juan Placido as an active revolutionary in the serial novel’s plot, Delany articulated not only a sophisticated theory of diasporic collaboration but also meditated on the stakes of fighting for black liberation by repeatedly employing accounts of black martyrdom.
Abject Performances
Authors: Alvarado Leticia 
Published: August 2018

In Abject Performances Leticia Alvarado draws out the irreverent, disruptive aesthetic strategies used by Latino artists and cultural producers who shun standards of respectability that are typically used to conjure concrete minority identities. In place of works imbued with pride, redemption, or celebration, artists such as Ana Mendieta, Nao Bustamante, and the Chicano art collective known as Asco employ negative affects—shame, disgust, and unbelonging—to capture experiences that lie at the edge of the mainstream, inspirational Latino-centered social justice struggles. Drawing from a diverse expressive archive that ranges from performance art to performative testimonies of personal faith-based subjection, Alvarado illuminates modes of community formation and social critique defined by a refusal of identitarian coherence that nonetheless coalesce into Latino affiliation and possibility.
Planar cell polarity: the prickle gene acts independently on both the Ds/Ft and the Stan/Fz systems
Authors: Casal José , Ibáñez-Jiménez Beatriz , Lawrence Peter A. 
Published: August 2018

ABSTRACT
Epithelial cells are polarised within the plane of the epithelium, forming oriented structures that have a coordinated and consistent polarity (planar cell polarity, PCP). In Drosophila, at least two separate molecular systems generate and interpret intercellular polarity signals: Dachsous/Fat, and the ‘core’ or Starry night/Frizzled system. Here, we study the prickle gene and its protein products Prickle and Spiny leg. Much research on PCP has focused on the asymmetric localisation of core proteins in the cell and as a result prickle was placed in the heart of the Starry night/Frizzled system. We investigate whether this view is correct and how the prickle gene relates to the two systems. We find that prickle can affect, separately, both systems; however, neither Prickle nor Spiny leg are essential components of the Dachsous/Fat or the Starry night/Frizzled system, nor do they act as a functional link between the two systems.
Kabell Mockbell and his coffee empire
Authors: Vincent Alison 
Published: August 2018

Abstract
The story of Kabell Mockbell and the coffee empire that he built demonstrates how the biographies of individuals, and even the limited amount of knowledge gained from secondary sources, can expand an appreciation of the past and challenge popular preconceptions. Mockbell was a self-described ‘Egyptian Turk, of Arab parentage’ living in Sydney throughout the First World War, negotiating the challenges of allegiance to his ancestry and to his new home. He was part of a cosmopolitan community long before post-Second World War migration brought large numbers of Europeans to Australia and government policies encouraged multiculturalism. Despite the popular belief that today’s coffee culture owes its origins to the espresso bars of the 1950s, Mockbell should be acknowledged as a much earlier personage to bring the coffee shop to Sydney.
Internet rumours with Chinese characteristics
Authors: Hearn Kay 
Published: August 2018

Abstract
Internet rumours are a global popular culture phenomenon. For instance, the claims that Barack Obama was not born in America persisted throughout his presidency. Despite the technological means used to control the Internet and the legislation against the spread of rumours there are many false stories on the Internet in China and removing them is a full-time task. Although the quote, ‘When you open the window, some flies may come in’ 打开窗户，苍蝇可能会飞进 (Deng Xiaoping on the Open Door Policy), refers to the opening up of China in 1978, it is still relevant as a response to the consequences of the Internet and the way it is managed. This article investigates the discourses surrounding the regulations about the spreading of rumours and argues that the regulations are used to maintain control over the narrative of events so as to preserve and reaffirm the government’s legitimacy to rule. The legislation is used as a justification to censor information that the government deems sensitive and this has been used as a reason to imprison activists and to shape popular culture. The regulations are also used to prevent widespread public panic or unrest, as was the case in 2011, when there was panic buying of salt thought to give protection from nuclear fallout that was rumoured to be heading to China from Fukushima. The application of the law can at times be arbitrary and planted rumours are used during factional fighting that is played out in the media and online. Xi Jinping has also used the tightening of rumour regulations as a part of factional fighting and in his consolidation of power. The following case studies act as empirical data to further illustrate the ways in which rumour and the legislative attempts to control it are used to shape Chinese cyberspace and online popular culture.
A class of exact solutions of equations for plane steady motion of incompressible fluids of variable viscosity in presence of body force
Authors: Ahmed Mushtaq , Ahmed Khan Waseem , M. Shad Ahsen S 
Published: August 2018

This paper determines a class of exact solutions for plane steady motion of incompressible fluids of variable viscosity with body force term in the Navier-Stokes equations. The class consists of stream function Â characterized by equation , in polar coordinates , Â where , Â and Â are continuously differentiable functions, derivative of Â is non-zero but double derivative of Â is zero. We find exact solutions, for a suitable component of body force, considering two cases based on velocity profile. The first case fixes both the functions , Â and provides viscosity as function of temperature. Where as the second case fixes the function , leaves Â arbitrary and provides viscosity and temperature for the arbitrary function . In both the cases, we can create infinite set of expressions for streamlines, viscosity function, generalized energy function and temperature distribution in the presence of body force.Â Â
POSISI UNDANG-UNDANG PERS INDONESIA DALAM EKOSISTEM MEDIA DIGITAL
Authors: Nurlatifah Mufti 
Published: August 2018

Aturan mengenai pers di Indonesia diatur oleh Undang-undang No.40 tahun 1999 tentang pers. Segala bentuk aktivitas jurnalisme, baik yang menggunakan media cetak, media penyiaran, dan media baru dilindungi dan dijamin oleh Undang-undang Pers. Pada perkembangannya, praktik jurnalistik pada media online tidak sesederhana formulasi pada undang-undang Pers. Ruang lingkup media baru yang menghadirkan sedemikian banyak kebaruan menghadirkan persoalan dilematis karena karakter media yang berbeda. Karakter media yang berbeda membuat aktivitas jurnalistik pada media baru juga mengalami pergeseran dan dinamika yang luar biasa. Hal ini pula yang kemudian menghadirkan persoalan dilematis di wilayah normatif dan etis. Berangkat dari asumsi tersebut, penelitian ini bermaksud ingin melihat bagaimana posisi Undang-undang Pers dalam ekosistem media baru. Penelitian ini berusaha menjawab posisi tersebut dalam dua aras. Pertama, penelitian ini hendak mengelaborasi bagaimana posisi Undang-undang Pers dalam konteks hukum media di Indonesia, baik dalam perspektif lex spesialis maupun perspektif lex generalis. Kedua, posisi Undang-undang Pers dalam penelitian ini dilihat dalam konteks empirik pada berbagai kasus jurnalisme media online di Indonesia. Konteks empirik ini lebih melihat pada bagaimana fakta yang terjadi di wilayah hukum dalam menanggapi berbagai persoalan terkait pers di media online. Indonesian Law No. 40 in 1999 on Press regulate Indonesia press activity in print media, electronic media, and online media. This law not only regulate press activity in collecting and reporting information but also guarantee freedom of the press in all Indonesian platform media. However, online journalism practice not as simple as the law. New media ecosystem challenge journalism practice, ethics, and regulation to the new level. New media character change journalism in many aspect, such as commentary, accuracy, and media management. These changes brought new perspective to discuss about regulation for online journalism. This research want to answer, how Indonesian Press Law taking position in new media ecosystem. First, we can discuss this position by elaborate Indonesian Press Law in lex specialist or in lec generalis condition. Second, we can compare Indonesian online journalism case which use Indonesian Press Law to justice.
LOYALITAS CUSTOMER DALAM MOBILE COMMERCE ZALORA
Authors: Pramesti Karina Dwi 
Published: August 2018

Saat ini smartphone menjadi instrumen yang sangat penting dalam dunia bisnis dan pemasaran. Penggunaan smartphone juga memicu tumbuhnya berbagai mobile commerce (m-commerce) di Indonesia. Hal ini disebabkan karena smartphone dapat menjadi sarana periklanan, promosi, dan transaksi jual beli. Salah satu perusahaan yang memanfaatkan hal ini adalah Zalora. Zalora merupakan salah satu perusahaan m-commerce dalam bidang fashion dengan pengunjung tertinggi di Indonesia. Namun, saat ini belum diketahui apakah terdapat hubungan antara kecenderungan penggunaan teknologi informasi dan komunikasi, kepuasan, serta kepercayaan terhadap loyalitas pelanggan pada Zalora. Metode pengumpulan data yang digunakan dalam penelitian ini adalah metode survei terhadap mobile buyers dari aplikasi zalora. Data yang dikumpulkan dianalisis dengan teknik analisis Structural Equation Modeling (SEM). Hasil penelitian ini menunjukan bahwa, kepuasan dan kepercayaan memiliki pengaruh positif terhadap loyalitas pelanggan E-Commerce Zalora. Kata Kunci: Kepercayaan, Kepuasan, Loyalitas, Mobile Commerce, Zalora Smartphones are becoming very important instruments in the business and marketing world today. The use of smartphones also trigger the growth of various mobile commerce (m-commerce) in Indonesia. This is because smartphones can be a means of advertising, promotion, and buying and selling transactions. One company that utilizes this is Zalora. Zalora is one of the m-commerce companies in the field of fashion with the highest visitors in Indonesia. However, it is not currently known whether there is a relationship between trends in use of information and communication technology, satisfaction, and trust in customer loyalty to Zalora. Data collection method used in this research is survey method to mobile buyers from zalora application. The data collected were analyzed by Structural Equation Modeling (SEM) analysis technique. The results of this study indicate that, satisfaction and trust have a positive influence on customer loyalty E-Commerce Zalora.
Continuous Dependence on Data for Solutions of Fractional Extended Fisher–Kolmogorov Equation
Authors: Chen Pengyu , Xin Zhen , An Jiahui 
Published: August 2018

Abstract
This paper is concerned with the continuous dependence of mild solutions on initial values and orders for a general class of initial boundary-value problem to fractional extended Fisher–Kolmogorov equation. The results obtained in this paper can be considered as a contribution to this emerging field.
Electrochemical corrosion behaviour of HVOF sprayed iron-based amorphous metallic coatings on AISI 316 stainless steel in an NaCl solution
Authors: Vignesh S. , Shanmugam K. , Balasubramanian V. , Sridhar K. , Thirumalaikumarasamy D. 
Published: August 2018

AbstractNew thermally sprayed amorphous metallic coatings have been developed recently that may provide a viable coating option for fluid handling equipment such as propellers, impellers and pumps. They possess the inherent risk of flow-dependent erosion-corrosion problems. In this investigation, iron based (Fe) amorphous coatings were deposited on AISI 316 stainless steel substrate by the high velocity oxy-fuel (HVOF) spraying process, and the coating microstructure was characterised using an optical microscope and scanning electron microscopy. The Fe-based amorphous coating consisted of an amorphous phase, an absence of dislocations, a nanocrystalline phase, less porosity and high hardness. The corrosion behaviour of the substrate and Fe-based amorphous coatings were evaluated by means of electrochemical tests in 3.5 wt.% NaCl solution. Three kinds of electrochemical tests were employed to identify the corrosion resistance of the coating and substrate. The results showed that the Fe30Cr25Mn5Mo20W10B5C3Si2 amorphous metallic coating had a superior corrosion resistance than 316 stainless steel. It was attributed to the amorphous structure and the presence of the corrosion resistant element chromium (Cr).
Experimental, Characterization and Optimization of the Pumping Power of an EDFA by a QPDSF Configuration
Authors: Bouchoucha Lydia , Sellami Mohammed , Berrah Smail 
Published: August 2018

Abstract
In this article, an experimental system based on the Quadruple Pass Double Stage with a tunable pass filter configuration, is used to amplify the output signal of the Erbium-doped fiber amplification and eliminate the noise due to the amplified spontaneous emission backwards.
The pumping power of the second stage is set at 220 mW, and the input power at −50 dBm, a maximum gain of 68 dB at a minimum noise threshold is achieved.