bluuebunny/crossref_metadata_2025_split huggingface dataset:
Savings and losses of global water resources in food‐related virtual water trade
Authors: Liu Wenfeng , Antonelli Marta , Kummu Matti , Zhao Xu , Wu Pute , Liu Junguo , Zhuo La , Yang Hong 
Published: September 2018

International food trade entails virtual water flows across trading partners. It has been proposed to attenuate regional water scarcity by importing water‐intensive commodities from water‐abundant regions. In addition to alleviating water scarcity in virtual water importing countries, existing studies have reported that food trade also generates global water savings. However, little is known how these global water savings may alleviate water scarcity, which is more relevant to the sustainable use of water resources than only assessing the savings. In this paper, we conducted a comprehensive review on studies of water savings and losses associated with food trade on different spatial scales. We found that the concept of global water savings is built on the disparities in water productivity across countries, whereas the regional water savings measure the inflows of virtual water trade. The significance of water savings is dimmed by the fact that the savings are often not driven by water scarcity. Meanwhile, lacking policy relevance impairs the usefulness of water saving accounting. Future studies should link water savings to alleviating water scarcity at various levels. The water saving accounting needs to go to finer scale, for example, to subnational and river basin scales, to support real water resource management. In the meantime, interdisciplinary efforts are necessary to enhance the water savings as a holistic measure for addressing water scarcity on regional and global scales.This article is categorized under:

Engineering Water > Planning Water
Human Water > Value of Water
Science of Water > Water Extremes
Does mhGAP training of primary health care providers improve the identification of child- and adolescent mental, neurological or substance use disorders? Results from a randomized controlled trial in Uganda
Authors: Akol A. , Makumbi F. , Babirye J. N. , Nalugya J. S. , Nshemereirwe S. , Engebretsen I. M. S. 
Published: September 2018

Background.Integrating child and adolescent mental health (CAMH) into primary health care (PHC) using the WHO mental health gap action program (mhGAP) is recommended for closing a mental health treatment gap in low- and middle-income countries, but PHC providers have limited ability to detect CAMH disorders. We aimed to evaluate the effect of PHC provider mhGAP training on CAMH disorder identification in Eastern Uganda.Methods.Thirty-six PHC clinics participated in a randomized controlled trial which compared the proportion of intervention (n= 18) to control (n= 18) clinics with a non-epilepsy CAMH diagnosis over 3 consecutive months following mhGAP-oriented CAMH training. Fisher's exact test and logistic regression based on intention to treat principles were applied. (clinicaltrials.gov registration NCT02552056).Results.Nearly two thirds (63.8%, 23/36) of all clinics identified and recorded at least one non-epilepsy CAMH diagnosis from 40 692 clinic visits of patients aged 1–18 recorded over 4 months. The proportion of clinics with a non-epilepsy CAMH diagnosis prior to training was 27.7% (10/36, similar between study arms). Training did not significantly improve intervention clinics’ non-epilepsy CAMH diagnosis (13/18, 72.2%) relative to the control (7/18, 38.9%) arm,p= 0.092. The odds of identifying and recording a non-epilepsy CAMH diagnosis were 2.5 times higher in the intervention than control arms at the end of 3 months of follow-up [adj.OR 2.48; 95% CI (1.31–4.68);p= 0.005].Conclusion.In this setting, mhGAP CAMH training of PHC providers increases PHC clinics’ identification and reporting of non-epilepsy CAMH cases but this increase did not reach statistical significance.
Floodplain Paleosols of Moskva River Basin: Chronology and Paleoenvironment
Authors: Alexandrovskiy A , Ershova E , Ponomarenko E , Krenke N , Skripkin V 
Published: September 2018

ABSTRACTSeven main periods of soil formation can be distinguished in the floodplain of the Moskva (Moscow) River, with the oldest paleosols dated to the Allerød age. We analyzed paleosols buried under alluvial deposits, colluvial sediments, and archaeological deposits within the catchment area of the Moskva River. Paleopedological reconstructions were correlated with the results of the pedoanthracological and palynological analyses. Series of radiocarbon (14C) dates were obtained on humic acids and dispersed macro-charcoal from paleosols and archaeological features. Wide time frames of the floodplain paleosol formation were determined at a 95% probability as 14,600–12,600 cal BP for Soil 7; 9500–7000 cal BP for Soils 6 and 5; 6700–5500 cal BP for Soil 4; 5000–4400 cal BP for Soil 3b; 4100–2700 cal BP for Soil 3a; and 2000–700 cal BP for Soil 2. The dates were compared with the age of archaeological sites from the same areas. The comparison revealed a close correspondence between the ages of the soil charcoal and the timing of archaeological occupations. That allowed us to conclude that the fire occurrence on a regional level was associated mainly with the human occupation. The fire record is especially pronounced in floodplain paleosols, due to both the role of rivers as human migration corridors, and the integral accumulation of combustion products from the entire catchment area in these paleosols.
Audiologist-led screening of acoustic neuromas in patients with asymmetrical sensorineural hearing loss and/or unilateral tinnitus: our experience in 1126 patients
Authors: Abbas Y , Smith G , Trinidade A 
Published: September 2018

AbstractObjectiveTo determine whether patients within an otolaryngology department presenting with asymmetrical sensorineural hearing loss and/or unilateral tinnitus can be safely and cost-efficiently screened for acoustic neuroma by audiologists as a first or only point of contact.MethodsA prospective case series and cost analysis were conducted at a tertiary referral centre. Between April 2013 and March 2017, 1126 adult patients presented to the audiology department with asymmetrical sensorineural hearing loss and/or unilateral tinnitus. All were screened for acoustic neuroma with magnetic resonance imaging, based on pre-determined criteria. The main outcome measure was the presence of acoustic neuroma or other pathology on magnetic resonance imaging.ResultsTwenty-five patients (2.22 per cent) were found to have an acoustic neuroma (size range: 3–20 mm) and were referred to the otolaryngologist for further assessment. The remaining patients were appropriately managed and discharged by the audiologists without ENT input. This resulted in an overall cost saving of £164 850.ConclusionPatients with asymmetrical sensorineural hearing loss and/or unilateral tinnitus can be safely screened for acoustic neuroma and independently managed by audiologists as a first or only point of contact, resulting in considerable departmental cost savings.
Heart rate variability during a cognitive reappraisal task in female patients with borderline personality disorder: the role of comorbid posttraumatic stress disorder and dissociation
Authors: Krause-Utz Annegret , Walther Julia-Caroline , Lis Stefanie , Schmahl Christian , Bohus Martin 
Published: September 2018

AbstractBackgroundEmotion dysregulation is a core feature of borderline personality disorder (BPD), which often co-occurs with posttraumatic stress disorder (PTSD). Difficulties in emotion regulation (ER) have been linked to lower high-frequency heart rate variability (HF-HRV), a measure of autonomous nervous system functioning. However, previous research on vagally-mediated heart rate in BPD revealed heterogeneous findings and the effects of comorbid PTSD and dissociation on HF-HRV are not yet completely understood. This study aim to investigate HF-HRV during resting-state and an ER task in female BPD patients with comorbid PTSD (BPD + PTSD), patients without this comorbidity (BPD), and healthy controls (HC).Methods57 BPD patients (BPD:n= 37, BPD + PTSD:n= 20) and 27 HC performed an ER task with neutral, positive, and negative images. Participants were instructed to either attend these pictures or to down-regulate their upcoming emotions using cognitive reappraisal. Subjective arousal and wellbeing, self-reported dissociation, and electrocardiogram data were assessed.ResultsIndependent of ER instruction and picture valence, both patient groups (BPD and BPD + PTSD) reported higher subjective arousal and lower wellbeing; patients with BPD + PTSD further exhibited significantly lower HF-HRV compared with the other groups. Higher self-reported state dissociation predicted higher HF-HRV during down-regulatingv.attending negative pictures in BPD + PTSD.ConclusionsFindings suggest increased emotional reactivity to negative, positive, and neutral pictures, but do not provide evidence for deficits in instructed ER in BPD. Reduced HF-HRV appears to be particularly linked to comorbid PTSD, while dissociation may underlie attempts to increase ER and HF-HRV in BPD patients with this comorbidity.
EFFECTS OF MASSING AND SPACING ON THE LEARNING OF SEMANTICALLY RELATED AND UNRELATED WORDS
Authors: Nakata Tatsuya , Suzuki Yuichi 
Published: September 2018

AbstractAlthough researchers argue that studying semantically related words simultaneously (semantic clustering) inhibits vocabulary acquisition, recent studies have yielded inconsistent results. This study examined the effects of semantic clustering while addressing the limitations of previous studies (e.g., confounding of semantic relatedness with other lexical variables). Furthermore, the study investigated the effects of spacing because spacing might facilitate the learning of semantically related items by alleviating interference. In this study, 133 Japanese university students studied 48 English-Japanese word pairs under two conditions: massed and spaced. Half the words were semantically related to each other while the other half were not. Although there were no significant differences between semantically related and unrelated items in posttest scores, semantically related items led to more interference errors than unrelated items. Furthermore, contrary to the authors’ hypothesis that spacing is particularly beneficial for semantically related items, spacing benefited unrelated items more than it did related items.
Institutionalisation of Knowledge-based Growth: the Case of the Dutch-Frisian Dairy Sector (1895–1950)
Authors: KNIBBE MERIJN , MOLEMA MARIJN 
Published: September 2018

Abstract:This article explores the outlines of an ‘agrarian-industrial knowledge society’ that developed from about 1895. Farmers, breeders, experts and leaders of dairy companies worked in close cooperation to increase the fat percentages in milk. The challenge was to measure these percentages on the farm, and process the information in a systematic way. Feedback mechanisms resulted in the selection of productive cows, because the fat content of milk is highly inheritable through the male as well as the female line. Data gathered from dairy companies and herd books in the Netherlands has uncovered considerable geographical differences in this process of knowledge-based growth. Focusing on Friesland, a Dutch province with a rich tradition of dairy farming, the importance of institutions is illustrated. A dairy counsellor, societies for milk measurement and cattle examination as well as price systems introduced by dairy companies advanced the biological quality of cows.
Doing Good, Choosing Freely: How Moral Enhancement Can Be Compatible with Individual Freedom
Authors: BROSTOFF JOSHUA M. 
Published: September 2018

Abstract:Moral enhancement has been accused of curtailing human freedoms. In this article, I suggest the opposite: moral enhancement and individual freedom can go hand in hand. The first section defines freedom, enhancement, and morality and argues that only a naturalistic account of morality allows for the concept of enhancement. The second section looks at ways that freedom may be threatened by moral enhancement, especially by the method of implementation, the creation of new externalities, or the limitation of volitional options. I argue that virtue ethics offers the safest model for moral enhancement. The third section describes ways in which moral enhancement can be achieved while maintaining, or even increasing, individual freedom. Such methods include shifting of the moral axis, replacing vicious options with virtuous ones, and increasing the number of volitional options available. The article concludes in the fourth section by arguing that the technology and techniques that allow us moral enhancement are likely to be the same ones that allow greater freedom than we already enjoy.
Looking Ahead: The Importance of Views, Values, and Voices in Neuroethics—Now
Authors: GIORDANO JAMES 
Published: September 2018

Abstract:The body-to-head transplant (BHT) planned to be undertaken later this year at China’s Harbin Medical University by neurosurgeons Sergio Canavero and Xiaoping Ren has attracted considerable attention and criticism. The intended operation gives rise to philosophical queries about the body–brain–mind relationship and nature of the subjective self; technical and ethical issues regarding the scientific soundness, safety, and futility of the procedure; the adequacy of prior research; and the relative merit, folly, and/or danger of forging new boundaries of what is biomedically possible. Moreover, that this procedure, which has been prohibited from being undertaken in other countries, has been sanctioned in China brings into stark relief ways that differing social and political values, philosophies, ethics, and laws can affect the scope and conduct of research. Irrespective of whether the BHT actually occurs, the debate it has generated reveals and reflects both the evermore international enterprise of brain science, and the need for neuroethical discourse to include and appreciate multicultural views, values, and voices.
Neuroscience and Social Problems: The Case of Neuropunishment
Authors: BUYX ALENA , BIRKS DAVID 
Published: September 2018

Abstract:Neuroscientific interventions are increasingly proposed as solutions for social problems, beyond their application in biomedicine. For example, there is increasing interest, particularly from outside commentators, in harnessing neuroscientific advances as an alternative method of punishing criminal offenders. Such neuropunishments are seen as a potentially more effective, less costly, and more humane alternative to incarceration, with overall better results for offender, communities, and societies. This article considers whether neuroscience as a field should engage more actively with such proposals, and whether more research should be done to explore the use of neurointerventions for punishment. It concludes that neuroscientists and those working at the intersection of neuroscience and the clinic should actively shape these debates.
Lack of access to paediatric cardiology services in the public health system in four major urban centres in Perú
Authors: Altamirano-Diaz Luis , Norozi Kambiz , Seabrook Jaime A. , Welisch Eva 
Published: September 2018

AbstractFor one-third of the Peruvian population living in large cities outside the capital city Lima, there is no access to paediatric cardiology services provided by the public health care system. Children with suspected CHD living in these areas are referred to the adult cardiologist working at the regional hospitals for care and treatment. This is a consequence of the universal health care system and the heavily skewed distribution of the health care workforce towards the capital city of Lima. This imbalance has resulted in a severe shortage of paediatric cardiologists practicing outside of Lima and the adult cardiologists that remain are left to make up for this deficit.To gain a better understanding of the current model of care for children with suspected CHD within the public health care system in Peru, we surveyed adult cardiologists from four major urban centres that serve one-third of the Peruvian population outside of Lima. We determined that adult cardiologists spend a significant amount of time treating children, but lack the specialised training and equipment to provide model care. The cardiologists indicated that receiving additional training and appropriate equipment would help enable them to provide proper care for these children.
Quantifying Climatic Controls on River Network Branching Structure Across Scales
Authors: Ranjbar Sevil , Hooshyar Milad , Singh Arvind , Wang Dingbao 
Published: September 2018

AbstractThe branching structure of river networks is an important topologic and geomorphic feature that depends on several factors (e.g., climate and tectonics). However, mechanisms that result in such branching patterns in river networks are poorly understood. Observations from natural catchments have revealed controls of climate on drainage density (Dd). In this study, we investigate the effects of climatic forcing on river network topology and geometry beyond Dd. For this, we selected 26 basins across the United States with equal Dd, however, different climate aridity index (defined here as the ratio of mean annual potential evaporation to precipitation). The river networks of these basins were extracted, using a curvature‐based method, from high‐resolution (1‐m) digital elevation models, and several metrics such as width functions, branching angles, and side branching ratio were computed. We used a multiscale entropy approach to quantify the geometric and topologic irregularity and structural richness of these river networks. Our results revealed the systematic impacts of climate forcing on the structure of river networks. We showed that the width functions of dry basins have higher entropy as compared to those of humid basins across spatial scales. Higher entropy suggests more heterogeneity in drainage network of dry basins. This heterogeneity is manifested in channels and their junctions resulting, on an average, in larger junction angle and longer channel links in dry basins compared to humid basins.
All carbon materials pn diode
Authors: Feng Xiaojing , Zhao Xing , Yang Liu , Li Mengyao , Qie Fengxiang , Guo Jiahui , Zhang Yuchun , Li Tiehu , Yuan Wenxia , Yan Yong 
Published: September 2018

AbstractSemiconductor pn junctions are elementary building blocks of many electronic devices such as transistors, solar cells, photodetectors, and integrated circuits. Due to the absence of an energy bandgap and massless Dirac-like behaviour of charge carriers, graphene pn junction with electrical current rectification characteristics is hardly achieved. Here we show a graphene pn junction diode can be made exclusively from carbon materials by laminating two layers of positively and negatively charged graphene oxides. As the interdiffusion of oppositely charged mobile counterions, a built-in potential is created to rectify the current by changing the tunnelling probability of electrons across the junction. This graphene diode is semi-transparent, can perform simple logic operations, and since it has carbon nanotubes electrodes, we demonstrate an all carbon materials pn diode. We expect this graphene diode will expand material choices and provide functionalities (e.g. grafting recognition units on graphene oxides) beyond that of traditional semiconductor pn junctions.
Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins
Authors: Winer Hila , Fraiberg Milana , Abada Adi , Dadosh Tali , Tamim-Yecheskel Bat-Chen , Elazar Zvulun 
Published: September 2018

AbstractAutophagy, a conserved membrane trafficking process, sequesters cytoplasmic components into autophagosomes and targets them for lysosomal degradation. The TNF receptor Fn14 participates in multiple intracellular signaling pathways and is strongly induced upon tissue injury and solid tumorigenesis. While Fn14 is a short-lived protein, the regulation of its levels is largely obscure. Here we uncover a role for autophagy in Fn14 turnover, wherein specific core autophagy Atg8 proteins play distinct roles: Fn14 accumulates in the ERGIC in absence of GABARAP but within endosomes in the vicinity of autophagic membranes in absence of GATE-16. Moreover, GABARAP regulates overall cellular levels of Fn14, whereas GATE-16 regulates TWEAK signaling by Fn14 and thereby NF-κB activity. These findings not only implicate different Atg8 proteins in distinct roles within the mechanism of selective autophagic regulation of Fn14, but may also provide a more general view of their role in mediating autophagosome biogenesis from different membrane sources.
Parsing cultural impacts on regret and risk in Iran, China and the United Kingdom
Authors: Li Li , Kumano Shiro , Keshmirian Anita , Bahrami Bahador , Li Jian , Wright Nicholas D. 
Published: September 2018

AbstractValue-based choices are influenced both by powerful counterfactuals, such as regret, and also by risk in potential outcomes. Culture can profoundly affect how humans perceive and act in the world, but it remains unknown how regret in value-based choice and key aspects of risk-taking may differ between cultures. Here our computational approach provides precise and independent metrics, grounded in extensive neurobiological evidence, for the influences of risk and regret on choice. We test for commonalities and differences across three diverse cultures: Iran, China and the UK. Including Iran matters because cross-cultural work on value-based choice is lacking for this key 21st Century culture, and also because patterns across the three cultures arbitrates between explanations for differences. We find commonalities, with regret influencing choice across cultures and no consistent cultural difference seen. However, for risk, unlike in both Chinese and Westerners’ choices, Iranians are risk-seeking – findings consistent across two task variants and further explained by Iranians showing less subjective impact of negative, but not positive, outcomes of risky choices. Our computational approach dissects cultural impacts on two key neurobiologically-grounded quantities in value-based choice, showing that neuroscientific accounts cannot a priori isolate such quantities from culture in the cognitive processes underlying choice.
AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage
Authors: Fang Cheng-Chieh , Wu Ching-Fen , Liao Yi-Jen , Huang Shiu-Feng , Chen Marcelo , Chen Yi-Ming Arthur 
Published: September 2018

AbstractGlycine N-methyltransferase (GNMT) is abundantly expressed in normal livers and plays a protective role against tumor formation. GNMT depletion leads to progression of hepatocellular carcinoma (HCC). In this study, we investigated the activity of ectopic GNMT delivered using recombinant adeno-associated virus (AAV) gene therapy in mouse models of liver cirrhosis and HCC. Injection of AAV serotype 8 (AAV8) vector carrying the GNMT gene (AAV8-GNMT) in Gnmt−/− mice increased GNMT expression and downregulated pro-inflammatory responses, resulting in reduced liver damage and incidence of liver tumors. Moreover, AAV8-GNMT resulted in the amelioration of carbon tetrachloride (CCl4)-induced liver fibrosis in BALB/c mice. We showed that AAV8-GNMT protected hepatocytes from CCl4-induced liver damage. AAV8-GNMT significantly attenuated the levels of pro-fibrotic markers and increased efficiency of hepatocyte proliferation. These results suggest that correction of hepatic GNMT by gene therapy of AAV8-mediated gene enhancement may provide a potential strategy for preventing and delaying development of liver diseases.