bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimensions of Anger Reactions‐Revised (DAR‐R): Validation of a brief anger measure in Australia and Spain
Authors: Kannis‐Dymand Lee , Salguero José M. , Ramos‐Cejudo Juan , Novaco Raymond W. 
Published: February 2019

AbstractObjectiveA validated, brief measure of anger is needed in clinical settings to screen for problematic anger. This study examined the validity of the seven‐item Dimensions of Anger Reactions‐Revised (DAR‐R), including a version for the Spanish population.MethodMultiple psychometric instruments administered to 541 (76.6% female) adults in Australia and 1,115 (56.3% female) in Spain were analyzed.ResultsA two‐factor model (anger response and anger impairment) was confirmed. Concurrent, convergent, and discriminant validity were supported. Anger response items strongly correlated with established measures of anger/aggression State‐Trait Anger Expression Inventory (Aggression Questionnaire), whereas anger impairment items strongly correlated with anxiety Generalized Anxiety Disorder‐7 and depression Patient Health Questionnaire‐9 measures. Internal consistency and test–retest reliability (3 months) were good. Cut‐off scores for problematic anger were established. There were no gender differences in anger in the Spanish sample, but Australian males had higher anger scores than females.ConclusionResults substantiate the utility of the DAR‐R as a concise, clinically informative measure of anger.
Regulation of autophagy as a therapy for immunosenescence‐driven cancer and neurodegenerative diseases: The role of exercise
Authors: Batatinha Helena Angelica Pereira , Diniz Tiego Aparecido , de Souza Teixeira Alexandre Abilio , Krüger Karsten , Rosa‐Neto Jose Cesar 
Published: February 2019

AbstractAging is one of the risk factors for the development of low‐grade inflammation morbidities, such as several types of cancer and neurodegenerative diseases, due to changes in the metabolism, hormonal secretion, and immunosenescence. The senescence of the immune system leads to improper control of infections and tissue damage increasing age‐related diseases. One of the mechanisms that maintain cellular homeostasis is autophagy, a cell‐survival mechanism, and it has been proposed as one of the most powerful antiaging therapies. Regular exercise can reestablish autophagy, probably through AMP‐activated protein kinase activation, and help in reducing the age‐related senescence diseases. Therefore, in this study, we discuss the effects of exercise training in immunosenescence and autophagy, preventing the two main age‐related disease, cancer and neurodegeneration.
The location of the fetal ears: A hint for prenatal diagnosis of agnathia‐otocephaly complex
Authors: Bijok Julia , Kucińska‐Chahwan Anna , Gielniewska‐Michalczyk Lena , Massalska Diana , Jakiel Grzegorz , Roszkowski Tomasz 
Published: February 2019

AbstractOtocephaly is an extremely rare lethal congenital anomaly characterized by the absence or underdevelopment of the mandible. The clinical presentation is variable. Some cases may present with severe micrognathia as the only anomaly seen prenatally. The key to early diagnosis is careful assessment of the location of the fetal ears on 2D ultrasound examination.
Ectopic spinal calcification associated with diffuse idiopathic skeletal hyperostosis (DISH): A quantitative micro‐ct analysis
Authors: Fournier Dale E. , Norley Chris J. D. , Pollmann Steven I. , Bailey Christopher S. , Al Helal Fahad , Willmore Katherine E. , Holdsworth David W. , Dixon S. Jeffrey , Séguin Cheryle A. 
Published: February 2019

ABSTRACTDiffuse idiopathic skeletal hyperostosis (DISH) is a non‐inflammatory spondyloarthropathy identified radiographically by calcification of the ligaments and/or entheses along the anterolateral aspect of the vertebral column. The etiology and pathogenesis of calcifications are unknown, and the diagnosis of DISH is currently based on radiographic criteria associated with advanced disease. To characterize the features of calcifications associated with DISH, we used micro‐computed tomographic imaging to evaluate a cohort of 19 human cadaveric vertebral columns. Fifty‐three percent of the cohort (n = 10; 3 females, 7 males, mean age of death = 81 years, range 67–94) met the radiographic criteria for DISH, with calcification of four or more contiguous vertebral segments. In almost all cases, the lower thoracic regions (T8‐12) were affected by calcifications, consisting primarily of large, horizontal outgrowths of bony material. In contrast, calcifications localized to the upper thoracic regions demonstrated variability in their presentation and were categorized as either “continuous vertical bands” or “discontinuous‐patchy” lesions. In addition to the variable morphology of the calcifications, our analysis demonstrated remarkable heterogeneity in the densities of calcifications, ranging from internal components below the density of cortical bone to regions of hyper‐dense material that exceeded cortical bone. These findings establish that the current radiographic criteria for DISH capture heterogeneous presentations of ectopic spine calcification that can be differentiated based on morphology and density. These findings may indicate a naturally heterogenous disease, potential stage(s) in the natural progression of DISH, or distinct pathologies of ectopic calcifications. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res
Preparation of a stoichiometric molecularly imprinted polymer for auramine O and application in solid‐phase extraction
Authors: Pataer Parezhati , Muhammad Turghun , Turahun Yunusjan , Yang Wenwu , Aihebaier Sailemayi , Wubulikasimu Muyasier , Chen Lingxin 
Published: February 2019

AbstractWe describe a stoichiometric approach to the synthesis of molecularly imprinted polymers specific for auramine O. Using the stoichiometric interaction in molecular imprinting, no excess of binding sites is necessary and binding sites are only located inside the imprinted cavities. The free base of the template was obtained to facilitate the interaction with the monomers. Itaconic acid was selected as the functional monomer, and stoichiometric ratio of the interaction with the free base was investigated. The molecularly imprinted polymer preparation conditions such as cross‐linker, molar ratio, porogen were optimized as divinylbenzene, 1:2:20 and chloroform/N,N‐dimethylformamide, respectively. Under the optimum conditions, a good imprinting effect and very high selectivity were achieved. A solid‐phase extraction method was developed using the molecularly imprinted polymers as a sorbent and extraction procedure was optimized. The solid‐phase extraction method showed a high extraction recovery for auramine O in its hydrochloride form and free form compared to its analogues. The results strongly indicated that stoichiometric imprinting is an efficient method for development of high selectivity molecularly imprinted polymers for auramine O.
Safety of office‐based percutaneous injection laryngoplasty with calcium hydroxylapatite
Authors: Lee Minhyung , Lee Doh Young , Kwon Tack‐Kyun 
Published: February 2019

ObjectiveTo evaluate the safety of office‐based calcium hydroxylapatite (CaHA) injection laryngoplasty via the cricothyroid approach through an analysis of all procedures performed over a period of 10 years at a single institution.MethodsIn total, 962 office‐based CaHA injection laryngoplasty via the cricothyroid approach procedures were performed by a single physician at our institution between 2007 and 2016. From these, 955 procedures performed in 617 patients were included in our analysis. The medical records of all 617 patients were retrospectively reviewed. We classified all procedure‐related complications according to the time of onset. Complications that occurred during the procedure were considered intraprocedural complications, whereas complications that developed within 1 week after injection and those that developed after 1 week and were recorded more than twice in the medical records were considered acute and delayed complications, respectively. Failed cases were categorized separately as failure.ResultsFive cases were failed (0.5%). Intraprocedural complications included superficial injection in eight cases (0.8%). Acute and delayed onset of dyspnea was observed in three (0.3%) and two (0.2%) cases, respectively. The incidence of failures and major complications requiring active intervention was 1.6%.ConclusionOur findings suggest that office‐based CaHA injection laryngoplasty via the cricothyroid approach is as safe as conventional transoral injection laryngoplasty.Level of Evidence4Laryngoscope, 129:2361–2365, 2019
Striatal spreading depolarization: Possible implication in levodopa‐induced dyskinetic‐like behavior
Authors: de Iure Antonio , Napolitano Francesco , Beck Goichi , Quiroga Varela Ana , Durante Valentina , Sciaccaluga Miriam , Mazzocchetti Petra , Megaro Alfredo , Tantucci Michela , Cardinale Antonella , Punzo Daniela , Mancini Andrea , Costa Cinzia , Ghiglieri Veronica , Tozzi Alessandro , Picconi Barbara , Papa Stella M. , Usiello Alessandro , Calabresi Paolo 
Published: February 2019

ABSTRACTObjectiveSpreading depolarization (SD) is a transient self‐propagating wave of neuronal and glial depolarization coupled with large membrane ionic changes and a subsequent depression of neuronal activity. Spreading depolarization in the cortex is implicated in migraine, stroke, and epilepsy. Conversely, spreading depolarization in the striatum, a brain structure deeply involved in motor control and in Parkinson's disease (PD) pathophysiology, has been poorly investigated.MethodsWe characterized the participation of glutamatergic and dopaminergic transmission in the induction of striatal spreading depolarization by using a novel approach combining optical imaging, measurements of endogenous DA levels, and pharmacological and molecular analyses.ResultsWe found that striatal spreading depolarization requires the concomitant activation of D1‐like DA and N‐methyl‐d‐aspartate receptors, and it is reduced in experimental PD. Chronic l‐dopa treatment, inducing dyskinesia in the parkinsonian condition, increases the occurrence and speed of propagation of striatal spreading depolarization, which has a direct impact on one of the signaling pathways downstream from the activation of D1 receptors.ConclusionStriatal spreading depolarization might contribute to abnormal basal ganglia activity in the dyskinetic condition and represents a possible therapeutic target. © 2019 International Parkinson and Movement Disorder Society
microRNA expression profile in porcine oocytes with different developmental competence derived from large or small follicles
Authors: Gad Ahmed , Nemcova Lucie , Murin Matej , Kanka Jiri , Laurincik Jozef , Benc Michal , Pendovski Lazo , Prochazka Radek 
Published: February 2019

AbstractOocyte developmental competence is acquired during folliculogenesis and regulated by complex molecular mechanisms. Several molecules are involved in these mechanisms, including microRNAs (miRNAs) that are essential for oocyte‐specific processes throughout the development. The objective of this study was to identify the expression profile of miRNAs in porcine oocytes derived from follicles of different sizes using RNA deep sequencing. Oocytes were aspirated from large (LO; 3–6 mm) or small (SO; 1.5–1.9 mm) follicles and tested for developmental competence and chromatin configurations. Small RNA libraries were constructed from both groups and then sequenced in an Illumina NextSeq. 500. Oocytes from the LO group exhibited higher developmental competence and different chromatin configuration compared with oocytes from the SO group. In total, 167 and 162 known miRNAs were detected in the LO and SO groups, respectively. MiR‐205, miR‐16, miR‐148a‐3p, and miR‐125b were among the top 10 highly expressed miRNAs in both groups. Eight miRNAs were differentially expressed (DE) between both groups. Target gene prediction and pathway analysis revealed 46 pathways that were enriched with miRNA‐target genes. The oocyte meiosis pathway and signaling pathways including FoxO, PI3K‐Akt, and cAMP were predictably targeted by DE miRNAs. These results give more insights into the potential role of miRNAs in regulating the oocyte development.
A projection‐based method for topology optimization of structures with graded surfaces
Authors: Luo Yunfeng , Li Quhao , Liu Shutian 
Published: February 2019

SummaryGraded surfaces widely exist in natural structures and inspire engineers to apply functionally graded (FG) materials to cover structural surfaces for performance improvement, protection, or other special functionalities. However, how to design such structures with FG surfaces by topology optimization is a quite challenging problem due to the difficulty for determining material properties of structural surfaces with prescribed variation rule. This paper presents a novel projection‐based method for topology optimization of this class of FG structures. Firstly, a projection process is proposed for ensuring the material properties of the surfaces vary with a prescribed function. A criterion of determining the values of parameters in projection process is given by a strict theoretical derivation, and then, a new interpolation function is established, which is capable of simultaneously obtaining clear substrate topologies and realizable FG surfaces. Though such structures are actually multimaterial gradient structures, only the design variables of single‐material topology optimization problem are needed. In the current research, the classical compliance minimization problem with a mass constraint is considered and the robust formulation is used to control the length scale of substrates. Several 2D and 3D numerical examples illustrate the validity and applicability of the proposed method.
On polynomial hyperreduction for nonlinear structural mechanics
Authors: Martynov Kirill , Wever Utz 
Published: February 2019

SummaryThis paper proposes an approach for hyperreduction of nonlinear structural mechanics equations. For hyperreduction, the nonlinear term is approximated by the third‐degree multivariate polynomials represented in terms of a monomial basis. The chosen basis leads to an ill‐conditioned minimization problem with the multivariate Vandermonde matrix. The condition number of the resulting problem is significantly improved by choosing an appropriate sparse subset of the initial basis. As a byproduct of the sparse basis, the evaluation time for the hyperreduced model is reduced drastically. The performance of the new approach is demonstrated for two typical applications.
The low‐risk perception of developing type 2 diabetes among women with a previous history of gestational diabetes: a qualitative study
Authors: Sharma Manisha , Purewal Tejpal Singh , Fallows Stephen , Kennedy Lynne 
Published: February 2019

We conducted a qualitative study to explore the risk perceptions, health beliefs and behaviours of women with a previous history of gestational diabetes mellitus (GDM).Women aged between 18 to 40 years (at the time of pregnancy) with a previous history of GDM, registered at The Royal Liverpool University Hospital, United Kingdom, participated in individual, semi‐structured, face‐to‐face interviews. Qualitative data from seven participants were collected until data saturation and were analysed by thematic analysis. Participants had a low‐risk perception of the future risk of developing diabetes. Some believed that their risk was the same as that of any other woman without a history of GDM, and some other participants were not aware of the risk at all and perceived GDM as a temporary health condition with no long‐term risks.Participants showed some understanding of a healthy lifestyle in general. However, most of the information was self‐acquired by participants and not linked to the future risk of developing diabetes. The findings of this research also indicated a contrast between the high perception of the immediate risks of complications during the pregnancy and low long‐term risk of developing diabetes after pregnancy associated with GDM. Participants received healthy lifestyle advice during their pregnancy, but none of them reported involvement in any postnatal health education, intervention or counselling as recommended by 2008 and 2014 NICE guidelines. The low‐risk perception impedes positive health behaviour required to overcome the barriers against a healthy lifestyle.This was a small research project but the findings warrant scope for more research in this field. A larger study might promote the development of a well‐structured, long‐term follow‐up health intervention programme, incorporating a reminder system for annual diabetes screenings to improve the risk perception and reduce the risk for the development of type 2 diabetes in this population. Copyright © 2018 John Wiley & Sons.
Self‐recovery and fatigue of double‐network gels with permanent and reversible bonds
Authors: Drozdov Aleksey D. , Christiansen Jesper deClaville , Dusunceli Necmi , Sanporean Catalina‐Gabriela 
Published: February 2019

ABSTRACTDouble‐network (DN) gels subjected to cyclic deformation (stretching up to a fixed strain followed by retraction down to the zero stress) demonstrate a monotonic decrease in strain with time (self‐recovery). Observations show that the duration of total recovery varies in a wide interval (from a few minutes to several days depending on composition of the gel), and this time is strongly affected by deformation history. A model is developed for the kinetics of self‐recovery. Its ability to describe stress–strain diagrams in cyclic tests with various periods of recovery is confirmed by comparison with observations on several DN gels. Numerical simulation reveals pronounced enhancement of fatigue resistance in multi‐cycle tests with stress‐ and strain‐controlled programs when subsequent cycles of deformation are interrupted by intervals of recovery. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys.2019,57, 438–453
Schooling in survivorship: Understanding caregiver challenges when survivors return to school
Authors: Paré‐Blagoev E. Juliana , Ruble Kathy , Bryant Camille , Jacobson Lisa 
Published: February 2019

AbstractObjectiveSchooling after treatment can hold challenges for survivors of childhood cancer and caregivers who may need to act as advocates on their behalf. This study seeks to understand caregiver experiences of survivor's school‐related challenges. This understudied area is critical given the 85% survivor rate for those diagnosed with childhood cancer and the disproportionate risk of learning difficulties faced by those with brain tumor or who receive therapy that targets the central nervous system.MethodsAffected caregivers participated in open‐ended interviews addressing school experiences during survivorship. Following preliminary analysis using a grounded theory approach, interviewees and other stakeholders from education, medical, and foundation communities participated in focus groups. Member‐check activities explored the validity of identified themes and a model derived from interview data describing schooling challenges during survivorship.ResultsCaregivers reported schooling‐related experiences were often stressful and such stressors recurred during survivors' ongoing education. They reported a lack of appropriate knowledge among themselves, school staff, and clinicians about issues their survivor faced as well as concerns about communication and uncertainties about the processes required to attain appropriate services. These themes of knowledge, communication, and process issues were embedded within family approaches to coping with difficulties as well as the specific types of late effects each survivor faced.ConclusionsThe proposed model and clinical implications provide a foundation for future research and intervention development. Such work is needed to more effectively support survivors and their caregivers with difficulties that arise during schooling following treatment for childhood cancer.
Interference of Metal Oxide Nanoparticles with Coagulation Cascade and Interaction with Blood Components
Authors: Lozano‐Fernández Tamara , Dobrovolskaia Marina , Camacho Tomás , González‐Fernández África , Simón‐Vázquez Rosana 
Published: February 2019

AbstractMetal oxide nanoparticles (NPs) are increasingly used for different purposes, showing a potential risk on human health. The analysis of the interaction of these metal oxide NPs with blood components is a crucial step in the characterization of their biocompatibility, but information available of comparative studies with several doses and different metal oxide NPs is really scarce. In this study, six different metal oxide NPs (TiO2, CeO2, Al2O3, Y2O3, and two different types of ZnO NPs) at different concentrations are used, and their potential adverse effects on blood are determined. Both, prothrombin time (PT) and activated partial thromboplastin time (aPTT), are assessed to understand particle influence on the plasma coagulation cascade. Additional hematocompatibility tests include assessment of thrombin coagulation time, platelet aggregation, leukocyte procoagulant activity (PCA), hemolysis, and complement activation. The results demonstrate that only the ZnO and TiO2 NPs affect the coagulation cascade by increasing the aPTT in a dose‐dependent manner. Moreover, ZnO NPs increase PT, while TiO2 NPs induce a decrease in the PT. In addition to affecting coagulation time, ZnO NPs also induce platelet aggregation and leukocyte PCA. All tested metal oxide NPs do not affect hemolysis and complement activation.
Overview obstacle maps for obstacle‐aware navigation of autonomous drones
Authors: Pestana Jesús , Maurer Michael , Muschick Daniel , Hofer Manuel , Fraundorfer Friedrich 
Published: February 2019

AbstractAchieving the autonomous deployment of aerial robots in unknown outdoor environments using only onboard computation is a challenging task. In this study, we have developed a solution to demonstrate the feasibility of autonomously deploying drones in unknown outdoor environments, with the main capability of providing an obstacle map of the area of interest in a short period of time. We focus on use cases where no obstacle maps are available beforehand, for instance, in search and rescue scenarios, and on increasing the autonomy of drones in such situations. Our vision‐based mapping approach consists of two separate steps. First, the drone performs an overview flight at a safe altitude acquiring overlapping nadir images, while creating a high‐quality sparse map of the environment by using a state‐of‐the‐art photogrammetry method. Second, this map is georeferenced, densified by fitting a mesh model and converted into an Octomap obstacle map, which can be continuously updated while performing a task of interest near the ground or in the vicinity of objects. The generation of the overview obstacle map is performed in almost real time on the onboard computer of the drone, a map of sizeis created in, therefore, with enough time remaining for the drone to execute other tasks inside the area of interest during the same flight. We evaluate quantitatively the accuracy of the acquired map and the characteristics of the planned trajectories. We further demonstrate experimentally the safe navigation of the drone in an area mapped with our proposed approach.