bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solving Fractional Telegraph Equation via Yang Decomposition Method
Authors: Abdulwahed Salem , Haleh Tajadodi  
Published: December 2024

In this study, we introduced a novel scheme to attain approximate and closed-form solutions of fractional telegraph equations, which belong to the most consequential amplitude equations in physics. The Yang transforms (YT) and the Adomian decomposition method (ADM) is combined in the proposed method. We call it the Yang Adomian decomposition method (YDM). Some examples are given to illustrate the accuracy of the numerical results by YDM. As a result, YDM demonstrates that it is a useful and simple mathematical tool for getting approximate and exact analytical solutions to linear-nonlinear fractional telegraph equations (FTEs) of the given kind. The convergence and absolute error analysis of the series solutions is also offered.
DEMO SAINS ALAT PERAGA MATEMATIKA TINGKAT SD DAN SMP SEBAGAI MEDIA PEMBELAJARAN DI WILAYAH KECAMATAN INSANA TENGAH
Authors: Luan Faustianus - , Sikas Oktovianus R , Obe Leonardus Frengky 
Published: December 2024

Alat peraga matematika merupakan media pembelajaran yang dapat membantu peserta didik dalam mengkonkritkan konsep yang abstrak menjadi lebih mudah untuk dipahami. Demo alat peraga matematika ini dilakukan di sekolah-sekolah jenjang Pendidikan Dasar (SD) dan Pendidikan Menengah Pertama (SMP) sebagai bagian dari pemahaman tingkat dasar serta ingin menunjukkan kepada peserta didik bahwa matematika itu asyik dan menyenangkan. Guru wajib dituntut untuk mampu menghasilkan alat peraga sebagai media pembelajaran yang dapat meningkatkan minat dan motivasi belajar dari peserta didik. Tujuan dari pengabdian ini adalah membantu guru-guru dan peserta didik dalam pengunaan dan pemanfaatan alat peraga matematika seperti mistar hitung bilangan bulat, bilangan pecahan, muter kali, timbangan bilangan dan tangga bilangan untuk peserta didik SD dan diperkenalkan juga media pembelajaran papan multi fungsi (MUSI) KPK dan FPB, D’happy van serta alat peraga papan SPLDV untuk peserta didik SMP. Media pembelajaran dan alat peraga matematika ini dapat membantu peserta didik dalam memecahkan persoalan-persoalan matematika. Metode yang digunakan selama kegiatan berupa ceramah, praktek dan diskusi. Kegiatan pengabdian ini dilaksanakan di SDK Maubesi I, yang dihadiri oleh para peserta didik dan guru-guru pendamping dari SDN Nakol dan SMP Satap Nakol Kecamatan Insana Tengah, Kabupaten TTU. Pelaksanaan kegiatan demo sains alat peraga matematika tersebut dapat mendorong dan membangkitkan semangat belajar peserta didik serta memberikan pemahaman yang positif dalam meningkatkan daya pikir baik dalam hal bertanya maupun berdiskusi. Dengan demikian, tim pengabdian sangat mengharapkan bimbingan dan pendampingan secara terus menerus dari guru dalam pembelajaran sehingga mampu menghasilkan dan meningkatkan media pembelajaran yang baik agar dapat menyelesaikan masalah-masalah sederhana dalam kehidupan sehari-hari dan lebih dari itu untuk meningkatkan minat dan motivasi belajar peserta didik di bangku pendidikan.
Papua dalam Perspektif Komentar Youtube: Studi Pemodelan Topik dan Analisis Sentimen dengan Pendekatan Text Mining
Authors: Bisoumi Yan Nazala , Munandar Jimy , Amrullah Setiawan , Pandiriyan Muhammad Tegar , Akmalia Kaia Raissa , Fauzi Fatkhurrokhman 
Published: December 2024

Studi ini bertujuan untuk mengidentifikasi pandangan masyarakat terhadap isu-isu terkait dengan Pulau papua melalui komentar dalam platform YouTube. Penggunaan pendekatan text mining dalam menerapkan pemodelan topik bertujuan mengidentifikasi topik-topik utama yang muncul pada diskusi di kolom komentar. Penentuan topik terbaik dilakukan dengan membandingkan akurasi metode Latent Dirichlet Allocation (LDA) dan Non-Negative Matrix Factorization (NMF). Hasil menunjukkan metode NMF lebih baik karena memiliki nilai coherence yang lebih tinggi, sehingga dilakukan analisis dengan metode VADER untuk mengetahui sentimennya. Tujuan pengklasifikasian ini adalah memahami emosi serta opini yang tercermin dalam komentar tersebut, apakah bersifat positif, negatif, atau netral. Hasil penelitian ini diharapkan dapat memberikan wawasan mendalam mengenai persepsi publik terhadap Papua.
THE EFFECTIVENESS OF THE PROSPEROUS HOUSING PROGRAM IN HULU SUNGAI SELATAN REGENCY AT SOUTH KALIMANTAN PROVINCE
Authors: Sukmana Mochammad Syachrur , Praja Selvia Junita 
Published: December 2024

Abstract: This research was initiated due to the level of social welfare of the community in Hulu Sungai Selatan Regency is still relatively low, which is characterized by the large number of uninhabitable residences. The aim of this research is to assess the effectiveness of the Prosperous Housing Program (PRS) policy stipulated in Hulu Sungai Selatan Regency Regent Regulation No. 25 of 2015 concerning Integrated Regional Poverty Management in Hulu Sungai Selatan Regency in increasing the number of livable housing for the community in Hulu Sungai Selatan Regency as well as knowing the obstacle factors, and the efforts to solve them. This research used a descriptive qualitative research method with an inductive approach. Data collection technique used in this research were interviews, documents and data, as well as observation. Interviews were conducted with related parties. Researchers also analysed the data using Riant Nugroho's theory regarding Policy Effectiveness. The research results show that the implementation of the Prosperous Housing Program (PRS) in improving the quality of community housings can be said to be successful and effective because it meets the achievement targets every year. However, there are still several obstacles to implementing this program. These obstacles are influenced by several factors, including lack of coordination between program implementing parties, short program implementation time, limited workforce and land ownership problems. Meanwhile, the efforts to solve the obstacles include forming a coordination team, careful time planning, increasing the quality and quantity of labour and providing information regarding land ownership.

Keywords: Policy Effectiveness, Habitable Housings, Community.
Optimizing glycemic control in type 2 diabetes: the impact of the GLIDE program’s personalized digital health intervention
Authors: Ambesange Anand , Khomane Amit Lala , Parikh Jaymin , Aswal Devina , Gharia Mihir , Sharma Prachi , Trivedi Vishva , Maheshwari Twinkle , Mishra Astha , Bhavsar Bhavan , Athavale Vrushali 
Published: December 2024

BackgroundThe integration of digital health applications into type 2 diabetes mellitus (T2DM) management presents promising opportunities for optimizing glycemic control, enhancing adherence, and improving health outcomes. MyTatva’s Glycemic Lifestyle Intervention in Diabetes Empowerment (GLIDE) program, which integrates dietary and exercise regimens, cognitive behavioral therapy (CBT), and Internet of Things (IoT) devices, potentiates this approach. This study aimed to evaluate the effectiveness of the GLIDE program’s personalized, comprehensive approach in improving glycemic control over 90 days among T2DM patients.MethodsDuring the study period, 30 diabetic patients completed their GLIDE journey with expert dieticians, physiotherapists, and behavior therapists. Each patient received a personalized root cause analysis based on lifestyle assessment and disease-specific parameters. Statistical analysis was conducted using a paired t-test on the deidentified HbA1c, FBS, and PPBS data at baseline and post-intervention.ResultsThroughout the study, 27 patients actively adhered to the GLIDE program. All the parameters showed statistically significant (p&lt;0.05) changes post-intervention. HbA1c decreased by 11.79% from 8.43% ± 1.32 to 7.44% ± 0.64. Significant reductions were observed in PPBS (47.7%), decreasing from 260.89 mg/dL ± 36.31 to 136.27 mg/dL± 6.36, compared to FBS (31.1%), which decreased from 8.43 mg/dL± 1.32 to 7.44 mg/dL± 0.64.ConclusionsThe effectiveness of the GLIDE program is based on a comprehensive root cause analysis approach. The detailed analysis of the patient’s clinical journey by health experts at regular intervals enables precise goal management, resulting in expected outcomes for better glycemic control. Therefore, personalized digital health plans are vital for achieving clinically significant changes.
Protective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling
Authors: Reilly-O’Donnell B. , Ferraro E. , Tikhomirov R. , Nunez-Toldra R. , Shchendrygina A. , Patel L. , Wu Y. , Mitchell A. L. , Endo A. , Adorini L. , Chowdhury R. A. , Srivastava P. K. , Ng F. S. , Terracciano C. , Williamson C. , Gorelik J. 
Published: December 2024

IntroductionCardiac fibrosis occurs in a wide range of cardiac diseases and is characterised by the transdifferentiation of cardiac fibroblasts into myofibroblasts these cells produce large quantities of extracellular matrix, resulting in myocardial scar. The profibrotic process is multi-factorial, meaning identification of effective treatments has been limited. The antifibrotic effect of the bile acid ursodeoxycholic acid (UDCA) is established in cases of liver fibrosis however its mechanism and role in cardiac fibrosis is less well understood.MethodsIn this study, we used cellular models of cardiac fibrosis and living myocardial slices to characterise the macroscopic and cellular responses of the myocardium to UDCA treatment. We complemented this approach by conducting RNA-seq on cardiac fibroblasts isolated from dilated cardiomyopathy patients. This allowed us to gain insights into the mechanism of action and explore whether the IL-11 and TGFβ/WWP2 profibrotic networks are influenced by UDCA. Finally, we used fibroblasts from a TGR5 KO mouse to confirm the mechanism of action.Results and discussionWe found that UDCA reduced myofibroblast markers in rat and human fibroblasts and in living myocardial slices, indicating its antifibrotic action. Furthermore, we demonstrated that the treatment of UDCA successfully reversed the profibrotic IL-11 and TGFβ/WWP2 gene networks. We also show that TGR5 is the most highly expressed UDCA receptor in cardiac fibroblasts. Utilising cells isolated from a TGR5 knock-out mouse, we identified that the antifibrotic effect of UDCA is attenuated in the KO fibroblasts. This study combines cellular studies with RNA-seq and state-of-the-art living myocardial slices to offer new perspectives on cardiac fibrosis. Our data confirm that TGR5 agonists, such as UDCA, offer a unique pathway of action for the treatment of cardiac fibrosis. Medicines for cardiac fibrosis have been slow to clinic and have the potential to be used in the treatment of multiple cardiac diseases. UDCA is well tolerated in the treatment of other diseases, indicating it is an excellent candidate for further in-human trials.
Development and validation of a fluency rating scale for Swiss German Sign Language
Authors: Haug Tobias , de Jong Nivja H. , Holzknecht Franz , Tissi Katja , Sidler-Miserez Sandra , Battisti Alessia , Perrollaz Regula , Ebling Sarah , Reinhard Sabine , Caminada Sarah 
Published: December 2024

IntroductionSign language fluency is an area that has received very little attention within research on sign language education and assessment. Therefore, we wanted to develop and validate a rating scale of fluency for Swiss German Sign Language (Deutschschweizerische Gebärdensprache, DSGS).MethodsDifferent kinds of data were collected to inform the rating scale development. The data were from (1) focus group interviews with sign language teachers (N = 3); (2) annotated DSGS data from users/learners with various levels of proficiency (i.e., deaf native signers of DSGS, hearing sign language interpreters, and beginning learners of DSGS, approximately CEFR level A1-A2) (N = 28) who completed different signing tasks that were manipulated by preparation time; (3) feedback from raters (N = 3); and (4) complimented with theory from spoken and sign language fluency.ResultsIn the focus group interview, sign language teachers identified a number of fluency aspects. The annotated DSGS data were analyzed using different regression models to see how language background and preparation time for the tasks can predict aspects of fluency (e.g., number and duration of pauses). Whereas preparation time showed only a slight effect in the annotated data, language background predicted the occurrence of fluency features that also informed the scale development. The resulting rating scale consisted of six criteria, each on a six-point scale. DSGS performances (N = 162) (same as the annotated data) from the different groups of DSGS users/learners were rated by three raters. The rated data were analyzed using multi-facet Rasch measurement. Overall, the rating scale functioned well, with each score category being modal at some point on the continuum. Results from correlation and regression analysis of the annotated data and rated DSGS performances complemented validity evidence of the rating scale.DiscussionWe argue that the different sources of data serve as a sound empirical basis for the operationalized “DSGS fluency construct” in the rating scale. The results of the analyses relating performance data to ratings show strong validity evidence of the second version of the rating scale. Together, the objective fluency measures explained 88% of the variance in the rating scores.
A blood-based mRNA signature distinguishes people with Long COVID from recovered individuals
Authors: Missailidis Daniel , Ebrahimie Esmaeil , Dehcheshmeh Manijeh Mohammadi , Allan Claire , Sanislav Oana , Fisher Paul , Gras Stephanie , Annesley Sarah J. 
Published: December 2024

IntroductionLong COVID is a debilitating condition that lasts for more than three months post-infection by SARS–CoV–2. On average, one in ten individuals infected with SARS CoV- 2 develops Long COVID worldwide. A knowledge gap exists in our understanding of the mechanisms, genetic risk factors, and biomarkers that could be associated with Long COVID.MethodsIn this pilot study we used RNA-Seq to quantify the transcriptomes of peripheral blood mononuclear cells isolated from COVID-recovered individuals, seven with and seven without Long COVID symptoms (age- and sex-matched individuals), on average 6 months after infection.ResultsSeventy genes were identified as significantly up- or down-regulated in Long COVID samples, and the vast majority were downregulated. The most significantly up- or downregulated genes fell into two main categories, either associated with cell survival or with inflammation. This included genes such as ICOS (FDR p = 0.024) and S1PR1 (FDR p = 0.019) that were both up-regulated, indicating that a pro-inflammatory state is sustained in Long COVID PBMCs compared with COVID recovered PBMCs. Functional enrichment analysis identified that immune-related functions were expectedly predominant among the up- or down-regulated genes. The most frequently downregulated genes in significantly altered functional categories were two leukocyte immunoglobulin like receptors LILRB1 (FDR p = 0.005) and LILRB2 (FDR p = 0.027). PCA analysis demonstrated that LILRB1 and LILRB2 expression discriminated all of the Long COVID samples from COVID recovered samples.DiscussionDownregulation of these inhibitory receptors similarly indicates a sustained pro-inflammatory state in Long COVID PBMCs. LILRB1 and LILRB2 should be validated as prospective biomarkers of Long COVID in larger cohorts, over time and against clinically overlapping conditions.
Antiangiogenic therapy exerts antitumor effects by altering the tumor microenvironment: bibliometric analysis
Authors: Kang Yuan , Kang Yixin , Zhang Dianbao , Yao Jun 
Published: December 2024

BackgroundAntiangiogenic therapy can alter the tumor microenvironment (TME) and thus exert anti-tumor effects, and has the potential to increase the efficacy of conventional therapy and immunotherapy. The aim of this study was to examine current research hotspots and collaborative networks on the relationship between previous antiangiogenic therapies and the TME through bibliometric analysis.MethodFrom the Web of Science Core Collection database, all publications from inception through December 2023 were downloaded. In-depth analysis was performed by Bibliometrix packages in R. Keywords and collaborative networks were analyzed using VOSviewers and Citespace.ResultWe obtained a total of 9027 publications. They come from 27 countries and were published in 1387 journals, with a total of 39,604 authors in the studied area. The number of publications increases dramatically from 2014 to 2023, accounting for 73.87% (6668/9027) of all publications. China and CANCERS have the highest number of publications on this topic and CANCER RESEACH is the most influential. In the last decade (2013- 2023), research has gradually shifted from studying the role of vascular endothelial growth factor in the TME to examining how antivascular therapy can contribute to the progression of cancer treatment. Furthermore, nanoparticle-based drug delivery systems and immunotherapy have been widely explored in the past five years. The findings of this study will help scientists to explore this promising field in depth by providing insight into the relationship between antiangiogenic therapy and the TME.ConclusionThe relationship between the antiangiogenic therapy and the TME has been developing rapidly, but cooperation between different institutions and countries is still limited. Researchers can use this study to identify hotspots and develop trends for related research, thereby facilitating the development and cooperative exchange in this field, as well as to suggest potential future research directions.
BMP-4 and fetuin A in systemic sclerosis patients with or without calcinosis
Authors: Lofaro Francesco Demetrio , Giuggioli Dilia , Bonacorsi Susanna , Orlandi Martina , Spinella Amelia , De Pinto Marco , Secchi Ottavio , Ferri Clodoveo , Boraldi Federica 
Published: December 2024

IntroductionSystemic sclerosis (SSc) is a connective tissue disease at the interface between inflammation and autoimmunity progressively leading to diffuse microvascular and fibrotic involvement of the skin and of multiple internal organs. Approximately, 20-40% of SSc patients suffer from cutaneous calcinosis, a debilitating manifestation due to calcium salt deposition in soft connective tissues, causing pain, ulceration, infection, and deformities, responsible of severe functional limitations. Pathomechanisms are poorly understood as well as markers/molecules capable to predict the risk of patients to develop calcinosis.MethodsAn observational study was performed in 51 female patients, 25 with and 26 without calcinosis to compare clinical and laboratory parameters and to evaluate pro- and anti-calcifying circulating markers and the in vitro serum calcification potential (T50). Moreover, calcinosis samples were analyzed to characterize their mineral composition.Results and discussionData demonstrate statistically significant differences in the prevalence of clinical manifestations and ACA and Scl70 autoantibodies in SSc patient with calcinosis compared to those without calcinosis. In SSc patients with calcinosis, serum levels of BMP-4 are higher, fetuin A might be regarded as a potential circulating prognostic marker and a negative correlation was observed between T50 and the global score of clinical manifestations, suggesting a potential predictive role of pro- and anti-calcifying molecules in SSc patients. Furthermore, calcinosis samples were characterized by the co-existence of phosphate and carbonate minerals with different stability and solubility. Further investigations on circulating markers in larger patient cohorts, especially at the early stages and throughout the natural course of the disease, may clarify their pathogenetic role in the SSc-related cutaneous calcinosis.
Bibliometric analysis of rehabilitation in Alzheimer’s disease (2000–2023): trends, hotspots and prospects
Authors: Jun Peng , Chengye Hao , Hui Wan 
Published: December 2024

BackgroundAlzheimer’s disease (AD) is a complex neurodegenerative disease that leads to insidious deterioration of brain functions and is considered the sixth leading cause of death in the world. Multiple studies have shown that rehabilitation therapy is becoming an important field of AD research in recent years.ObjectiveWe opted for bibliometric analysis to comprehensively summarize the advancements in the study of AD rehabilitation treatment, aiming to provide researchers with current trends and future research directions.MethodsAll articles and reviews pertaining to rehabilitation treatment in Alzheimer’s disease from 2000 to 2023 were downloaded through Web of Science Core Collection. The results were subjected to bibliometric analysis using Microsoft Excel (2019 version), CiteSpace (6.3 R1 Advanced) and VOSviewer 1.6.20.ResultsOverall, 1,284 publications were included. The number of publications was increasing yearly. The United States has published the most publications. University of Toronto has published the most papers of all institutions. NEUROPSYCHOLOGICAL REHABILITATION and ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION were the journals with the most studies and the most commonly cited, respectively. Clare L is the author with the highest productivity and co-citation. After analysis, the most common keywords are mild cognitive impairment, cognitive, impairment memory and executive function indicates that cognitive impairment is the main focus of research. Transcranial magnetic stimulation, cognitive rehabilitation, and physical activity/exercise are the hotspots of research at the present stage and are likely to continue.ConclusionDistinguishing non pharmacological treatments at different stages of development is a research hotspot in AD rehabilitation; Sports intervention, brain functional imaging techniques represented by brain functional connectivity, virtual reality, and quality of life are research directions that need attention.
Composite dietary antioxidant index mediates the effect of epilepsy on psychiatric disorders: results from NHANES 2013–2018
Authors: He Xingyan , Li Zhiling , Wu Haotian , Wang Lifen , Zhang Yuxin 
Published: December 2024

BackgroundPsychiatric disorders is a major public health problem and epilepsy contributes significantly to depression. We aimed to explore the relationship between dietary patterns and mental illness in patients with epilepsy.MethodsThe data presented here are based on the 2013–2018 National Health and Nutrition Examination Survey (NHANES). In this study, the t-test and chi-square tests or one-way analysis of variance (ANOVA) were employed for the analysis of continuous and categorical variables, respectively. Restricted cubic splines (RCSs) with four knots were employed to investigate the linear relationship and trend between the Composite Dietary Antioxidant Index (CDAI) and epilepsy and psychiatric disorders, respectively. In instances where the linear relationship was not deemed to be applicable, the CDAI was categorized into four groups based on quartiles. A logistic regression analysis was employed to investigate the relationship between epilepsy and mental disorders under four distinct models. A mediation analysis was employed to ascertain whether CDAI acted as a mediator in the relationship between epilepsy and mental disorders.ResultsPatients with epilepsy had a significantly lower CDAI (p &lt; 0.001) and a significantly higher prevalence of psychiatric disorders (p = 0.02) compared with non-epileptic patients. Mediation modeling showed that CDAI mediated between 3.17 and 5.21% of epilepsy-related psychiatric disorders. In stratified analyses, the prevalence of psychiatric disorders was increased in the second quartile subgroup and the third quartile subgroup of the CDAI dietary index in patients with epilepsy compared with non-epileptic patients.ConclusionOur findings suggest that patients with epilepsy have a high risk of developing psychiatric disorders and that the Composite Dietary Antioxidant Index (CDAI) plays a key role in mediating the relationship between epilepsy and psychiatric disorders.