bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Customer Journey in Second‐Hand Fashion Platforms: Implications for Luxury Brand Management
Authors: Murtas Gabriele , Pedeliento Giuseppe 
Published: November 2024

ABSTRACTConsumers' increasing environmental concerns are prompting a shift in fashion consumption, fueling the remarkable growth of the second‐hand market. Over the last decade, this trend has spurred the emergence of a plethora of online platforms dedicated to the resale of pre‐loved fashion items. As consumers can easily access luxury garments at affordable prices through second‐hand platforms, the rapid expansion of these indirect channels holds the potential to further redefine how consumers experience and access luxury, significantly contributing to its democratization. While scholarly interest in second‐hand luxury has recently surged, current research has overlooked the experience consumers live when purchasing from such channels. Our research aims to fill this gap by delving into the customers' journey within these marketplaces, unraveling their experiences, perceptions, and decision‐making processes when purchasing second‐hand luxury. Twenty‐four in‐depth interviews with established luxury consumers who have recently purchased second‐hand luxury items through these platforms were conducted. The customer experience and journey framework was applied as a theoretical lens to make sense of such interactions. The findings reveal that consumers are drawn by the perceived endless availability of luxury items and the opportunity to compare different listings. Still, concerns over brand dilution, counterfeiting, and the absence of a sought‐after luxury experience pose significant challenges during the customer journey. This research contributes to the emerging field of second‐hand luxury by shedding light on the intricacies of the customer experience within these platforms. The article concludes with managerial insights aimed at assisting luxury brand managers in developing strategies and tactics in a market environment where second‐hand platforms are gaining momentum.
Innovative Pyrazole Hybrids: A New Era in Drug Discovery and Synthesis
Authors: Bendi Anjaneyulu , Devi Poonam , Sharma Harsh , Yadav Geetanjali , Raghav Neera , Pundeer Rashmi , Afshari Mozhgan 
Published: November 2024

ABSTRACTHeterocyclic compounds that include nitrogen and their derivatives have long been regarded as excellent sources of medicinal substances. Pyrazole is a compound with two nitrogen atoms and an aromatic structure. It has several uses and intricate stereochemistry arranged in a five‐membered ring. The knowledge of different pyrazole derivatives and their range of physiological and pharmacological actions has grown significantly in recent years. The scientific community has recently increasingly focused on exploring the chemistry of various pyrazole hybrids due to their enhanced biological activities. This review investigates the chemistry of these diverse pyrazole hybrids, emphasizing their synthesis and their antidiabetic, antibacterial, anticancer, antimicrobial, antioxidant, and anti‐inflammatory activities. Articles published from 2014 onward with an emphasis on the last 5 years are included in this review. This review is anticipated to be useful for future investigations and innovative concepts in the pursuit of designs for creating more promising hybrids of pyrazoles.
Expanded‐Access Use of Elamipretide Improves Quality of Life in Patients With Rare Mitochondrial Disorders Characterized by Ophthalmic Symptoms: A Case Series
Authors: Ansari Sharique , Koenig Mary Kay 
Published: November 2024

ABSTRACTThis case series presents the use of elamipretide in two patients with different progressive mitochondrial disorders (chronic progressive external ophthalmoplegia [CPEO] plus and neuropathy, ataxia, and retinitis pigmentosa [NARP] syndrome) characterized by ophthalmic traits. Elamipretide was well tolerated and both patients demonstrated improvement in symptoms while on therapy.
Vestibular Syncope and Acute Peripheral Vestibular Deficit: A Case Report
Authors: Motta Noemi , Gitto Marco , Castelli Valeria , Tobaldini Eleonora , Montano Nicola , Di Berardino Federica 
Published: November 2024

ABSTRACTVestibular syncope is a rare condition in which vertigo may cause syncopal attacks; however, the term has been associated with confusion because it has been ascribed to completely different vestibular and neurological conditions, from dizziness to Menière disease (MD), to the neurovegetative symptoms in benign paroxysmal positional vertigo (BPPV) and central vertebrobasilar hyperfusion. A 75‐year‐old woman with vasodepressive vasovagal syncope, confirmed by a tilt test with trinitrine administration, was referred for an audiological and vestibular assessment showing an acute unilateral peripheral vestibular deficit on the right side. The diagnosis is peripheral acute vestibular deficits. Interventions and outcomes are vestibular treatment and rehabilitation. The patient's vasovagal symptoms immediately improved and were completely resolved. Peripheral vestibular deficits might also trigger syncopal episodes and must be considered and studied by a complete audiological and vestibular evaluation. By restoring the peripheral vestibular function of the right labyrinth after vestibular treatment, a complete long‐term resolution of multiple vasovagal syncopal episodes was observed together with normalization of the tilt test.
Co‐Trimoxazole‐Induced Toxic Epidermal Necrolysis: A Case Report From Nepal
Authors: Gaire Sandesh , Chhetri Suchit Thapa 
Published: November 2024

ABSTRACTStevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous reactions, often triggered by medications, characterized by blistering and epithelial sloughing. We report the case of a 66‐year‐old male who presented with a 2‐day history of fluid‐filled lesions on his body. On examination, erosions were observed on the posterior and anterior trunk, as well as on both upper and lower limbs. Multiple vesicles and bullae were scattered bilaterally, involving 60%–70% of the body surface area. Co‐trimoxazole‐induced SJS was diagnosed. The patient was admitted to the ICU and treated with dexamethasone, hydrocortisone, imipenem, and azithromycin. Corticosteroids, combined with broad‐spectrum antibiotics, were effective in managing the condition. Early intervention and a multidisciplinary approach helped prevent complications and secondary infections.
Recent Advances in Covalent Organic Framework for Selective Photocatalytic Reduction of CO2
Authors: Deshmukh Shubham Avinash , Bhuse Darpan Vijaykumar , Suresh Selvaraj , Raut Subodh Uttamrao , Kondawar Sharda , Sarkar Sujit , Patel Chandan , Agawane Ganesh 
Published: November 2024

AbstractPhotocatalytic transformation of CO2 into clean fuels and chemicals is a promising solution to address both the energy dilemma and environmental issues. Recent years have seen several efforts to improve the effectiveness and selectivity of CO2 conversion by creating photocatalysts and reduction devices. An alternative to fossil fuels is urgently needed to address the rising energy demand and pollution. Porous heterogeneous catalysts are gaining popularity for carbon capture, with recent breakthroughs in design and application for CO2 conversion. Covalent organic frameworks (COFs) are porous crystalline polymeric materials made up of organic module units held together by strong covalent connections. COFs have numerous applications, including adsorption and separation, detection, catalysis, optoelectronic components, energy storage, and mass transport, due to their low density, massive specific surface area, superior thermal stability, developed pore structure, long‐range sequence, good crystallinity, and excellent tunability of monomer units. In this review, we discuss the synthetic process, morphology, and linkage of COFs. We also elaborate the types of activations for CO2, that is, thermal, electrocatalytic, and photocatalytic activation. Finally, we discuss the application of COFs for conversion of CO2 to value added product (VAC).
Process Understanding of Transamination Reaction in Chiral Pharmaceutical Intermediate Production Catalyzed by an Engineered Amine Transaminase
Authors: Perçin Zeynep , Kleinbeck Florian , Bubenheim Paul , Ruch Thomas , Liese Andreas 
Published: November 2024

AbstractChiral amines are key building blocks for the synthesis of many active pharmaceutical ingredients (APIs). Biocatalytic routes offer significant advantages to provide sustainable access to such motifs on commercial scale, with sacubitril valsartan sodium hydrate as a recent example. In this study a deeper mechanistic and kinetic understanding of the central biocatalytic step in the synthesis of sacubitril valsartan sodium hydrate, applying the evolved transaminase CDX‐043, was gained. The equilibrium of the transamination reaction was investigated in detail, and two kinetic models (ping‐pong two‐substrate kinetics and Michaelis–Menten double substrate kinetics) were established, considering substrate and product inhibition. The determined equilibrium constant indicates that the equilibrium lies strongly on the product side. The results of the kinetic studies demonstrate that the transaminase reaction is in conformity with the Michaelis–Menten double substrate kinetic model. Product inhibition was found to be more severe than substrate inhibition. The application of a plug flow reactor (PFR) was shown to be the preferred reactor setup to reduce the occurring inhibition.
Rare Case of Germline GATA2‐Deficiency With Merkel Cell Carcinoma and Acute Myeloid Leukemia
Authors: Yu SooHo , Park Min‐Seung , Kim Gyu Yeong , Cho Junhun , Jung Chul Won , Kim Hee‐Jin , Kim Hyun‐Young 
Published: November 2024

ABSTRACTBackgroundGermline GATA2‐deficiency usually manifests as immunodeficiencies and myeloid neoplasms and sometimes with dermatological diseases, including warts, panniculitis, and skin cancers.CaseWe report a 36‐year‐old woman with germline GATA2‐deficiency who developed Merkel cell carcinoma followed by acute myeloid leukemia. Molecular analysis revealed a germline GATA2 S447R variant, not reported from the previous reported case, suggesting a potential association with Merkel cell carcinoma.ConclusionThis case broadens the spectrum of solid cancers linked to GATA2‐deficiency, emphasizing the need for considering primary immunodeficiency in young patients with myeloid neoplasms or rare skin cancers, facilitating early detection and treatments.
Prognostic Models Using Machine Learning Algorithms and Treatment Outcomes of Papillary Thyroid Carcinoma Variants
Authors: Alshwayyat Sakhr , Kamal Haya , Ghammaz Owais , Alshwayyat Tala Abdulsalam , Alshwayyat Mustafa , Odat Ramez M. , Hanifa Hamdah , Asha Wafa , Saadeh Nesreen A. 
Published: November 2024

ABSTRACTBackgroundHürthle cell (HCC) and columnar cell variants (CCV) are rare subtypes of thyroid cancer.AimsThis study used machine learning (ML) to evaluate treatment effectiveness and develop prognostic models.MethodsChi‐square tests, Kaplan–Meier curves, log‐rank tests, and Cox regression were used. Five ML algorithms constructed prognostic models predicting 5‐year survival, validated using the AUC of the ROC curve.ResultsAmong 3690 patients, 3180 had CCV and 510 had HCC. ML models showed metastasis, surgery + RT, and age were significant factors for HCC, while the N component of TNM, metastasis, and tumor size were significant for CCV.ConclusionThis study offers a comprehensive approach for treating and assessing prognosis in PTC variants. The ML models developed offer practical tools for personalized clinical decision‐making.
The consequence of mismatched buffers in purity checks when spectral cell sorting
Authors: Dapaah Rita A. S. , Ferrer‐Font Laura , Shi Xiaoshan , Hall Christopher , Thompson Sam , Costa Larissa Catharina , Mage Peter L. , Tyznik Aaron J. , Lundsten Kelly , Walker Rachael V. 
Published: November 2024

AbstractAlthough spectral flow cytometry has become a ubiquitous tool for cell analysis, the use of spectral cytometry on cell sorters requires additional considerations arising from the unique requirements of sorting workflows. Here, we show that care should be taken when ascertaining the purity of a sort on a spectral cell sorter, as the mismatch of buffers used for initial sample suspension and the buffers used for sort collection can affect the unmixing of the data, potentially giving rise to erroneous purity check results.
Lymph node metastasis risk factors in T2 colorectal cancer
Authors: Morita Yuriko , Kudo Shin‐ei , Takashina Yuki , Ichimasa Katsuro , Kouyama Yuta , Semba Shigenori , Mochizuki Kenichi , Shiina Osamu , Kato Shun , Kuroki Takanori , Shimada Shoji , Nakahara Kenta , Takehara Yusuke , Mukai Shunpei , Ogata Noriyuki , Hayashi Takemasa , Wakamura Kunihiko , Miyachi Hideyuki , Sawada Naruhiko , Nemoto Tetsuo , Baba Toshiyuki , Misawa Masashi 
Published: November 2024

AbstractObjectivesThis study evaluates risk factors for lymph node metastasis (LNM) in T2 colorectal cancer to refine patient selection for endoscopic resection.MethodsWe reviewed records from consecutive patients who had undergone curative surgical resection of T2 colorectal cancer at our institution in Japan between April 2001 and December 2021. Data on conventional clinicopathologic variables were retrieved from the pathology reports at the time of surgery. The clinicopathological features included patient age, sex, tumor diameter, morphology, tumor location, lymphatic invasion, vascular invasion, tumor differentiation, carcinoembryonic antigen and carbohydrate antigen 19‐9 levels, number of lymph node dissections, presence of adenoma component, and LNM.ResultsAmong the patients (338 men, 320 women), 170 (25.8%) exhibited LNM. Multivariate logistic regression identified three independent risk factors for LNM: lymphatic invasion (odds ratio [OR], 32.6; 95% confidence interval [CI], 17.3–61.4; p < 0.0001), female sex (OR, 1.70; 95% CI, 1.10–2.62; p = 0.02), and elevated carcinoembryonic antigen levels (OR, 2.56; 95% CI, 1.10–5.96; p = 0.03).ConclusionsLymphatic invasion, female sex, and high carcinoembryonic antigen levels significantly increase the risk of LNM in T2 colorectal cancer.
Forecasting the Effects of Global Change on a Bee Biodiversity Hotspot
Authors: Buckner Mark A. , Hoge Steven T. , Danforth Bryan N. 
Published: November 2024

ABSTRACTThe Mojave and Sonoran Deserts, recognized as a global hotspot for bee biodiversity, are experiencing habitat degradation from urbanization, utility‐scale solar energy (USSE) development, and climate change. In this study, we evaluated the current and future distribution of bee diversity, assessed how protected areas safeguard bee species richness, and predicted how global change may affect bees across the region. Using Joint Species Distribution Models (JSDMs) of 148 bee species, we project changes in species distributions, occurrence area, and richness under four global change scenarios between 1971 and 2050. We evaluated the threat posed by USSE development and predicted how climate change will affect the suitability of protected areas for conservation. Our findings indicate that changes in temperature and precipitation do not uniformly affect bee richness. Lower elevation protected areas are projected to experience mean losses of up to 5.8 species, whereas protected areas at higher elevations and transition zones may gain up to 7.8 species. Areas prioritized for future USSE development have an average species richness of 4.2 species higher than the study area average, and lower priority “variance” areas have 8.2 more species. USSE zones are expected to experience declines of up to 8.0 species by 2050 due to climate change alone. Despite the importance of solitary bees for pollination, their diversity is often overlooked in land management decisions. Our results show the utility of JSDMs for leveraging existing collection records to ease the inclusion of data‐limited insect species in land management decision‐making.
Global Terrestrial Water–Energy Coupling Across Scales
Authors: Mbabazi Deanroy , Sehgal Vinit , Mohanty Binayak P. 
Published: November 2024

ABSTRACTTerrestrial water–energy coupling (WEC), in the form of a non‐linear relationship between Soil Moisture (SM) and evaporative fraction (EF, ratio of actual and potential evapotranspiration), controls critical ecohydrological processes. We investigate and parameterize the evolution of global SM–EF coupling from the field to remote‐sensing (RS)‐pixel. The field‐scale EF and SM were obtained from eddy covariance (EC) and SM sensors at the global FLUXNET and Texas Water Observatory sites. RS‐pixel‐scale EF and SM estimates were obtained from Moderate‐resolution Imaging Spectroradiometer (MODIS) and Soil Moisture Active Passive (SMAP) sensors, respectively. We estimate the effective thresholds of the WEC regimes from both EC and satellite datasets to highlight the influence of sub‐pixel‐scale heterogeneity, and, scaling and observational constraints on the evolution of WEC regimes from the field to RS‐pixel scale. We argue that the changes in land surface conditions add a temporal variability in the critical thresholds of terrestrial WEC at RS pixel scale. We compare the critical WEC thresholds of the water‐ and energy‐limited regimes with a SM drydown‐based approach and highlight the similarities between both methods in partitioning dominant WEC regimes. EF and SM are strongly coupled in dryland arid and semi‐arid regions compared to humid climates. WEC regimes and thresholds have strong interseason variability due to dynamic interactions between soil, vegetation and atmosphere at the RS‐pixel scale. In contrast, field‐scale SM‐EF coupling is influenced predominantly by soil conditions and land‐use/management practices. Hence, future development of Earth‐system/Land‐surface models must account for the inter‐scale differences in the coupling between terrestrial water and energy fluxes representative of the ‘effective’ processes at large spatial scales.
Linking the Flow Regime of Papyrus‐Dominated Wetlands to Biologically Relevant Hydrologic Attributes
Authors: Oyarmoi Alem , Birkinshaw Stephen , Hewett Caspar J. M. , Fowler Hayley J. 
Published: November 2024

ABSTRACTThe dominant plant species in many African wetlands is Cyperus papyrus. Its adaptation to saturated and low‐oxygen conditions and its dense structure and height provide breeding and feeding grounds for unique flora and fauna. As a keystone species adapted to local hydrology, the flooding regime of papyrus offers the full range of hydrologic conditions and events essential to ecosystem health. However, no study has attempted to link papyrus wetlands' flow regimes to their biologically relevant hydrologic attributes. This study assesses hydrologic alterations of a papyrus wetland's flow regime due to rice irrigation. We develop a conceptual ecological model linking papyrus to hydrologic attributes to determine the consequences of changed environmental flow components (EFCs) on papyrus as a habitat. We find that agricultural water management considerably alters the magnitude, duration, timing and rate of change of EFCs, which could affect productivity (seed dispersal, germination and establishment; rhizome spreading; papyrus distribution across transects; and dispersal of floating mats) in papyrus wetlands. However, the effect on the papyrus wetlands' natural pulsed regime is negligible when the ratio of irrigated area to catchment area is no greater than 1:150. Overall, a better understanding of the threats of water diversion for agriculture is made by linking papyrus' flow regimes to biologically relevant hydrologic attributes. Knowledge of the roles of the various EFCs could provide opportunities for conserving and protecting papyrus wetlands, especially for systems at risk of altered flows.
Redox Reactions of [RuIII(pic)3] (pic−=picolinate) with Sulfite in Aqueous Solution: Kinetic, and Mechanistic Studies
Authors: Impert Olga , Chatterjee Debabrata 
Published: November 2024

AbstractThe reaction of [RuIII(pic)3] (pic−=picolinate) and sulfite (SO32−) resulting in the formation of [RuII(pic)3] − and sulfate (SO42−) has been studied spectrophotometrically and kinetically in aqueous solution. The rate of the reaction studied by following the appearance of the MLCT (metal to ligand charge transfer) band of the [RuII(pic)3)]− complex at 466 nm was found to be first‐order in both the complex and sulfite concentrations. The values of the observed rate constant depend on the pH, since it controls the speciation of oxoanions of sulfur(IV)‐species viz. bisulfite (HSO3−) and sulfite (SO32−) in the pH range 3.8 to 8.3. The product of the reaction, sulfate was ascertained by LDI‐mass spectral analysis ofthe post‐reaction solution. The activation parameters (ΔH≠ =56±3 kJ mol−1 and ΔS≠= ‐179±9 J mol−1 K−1) corresponding to the reduction of [RuIII(pic)3] with SO32− supports the operation of an outer‐sphere electron transfer mechanism. The experimentally observed electron‐transfer rate constant (k=5.60 M−1s−1 at 25 °C) is found to be in good agreement with that of calculated (k12=4.75 M−1s−1) using Marcus cross‐reaction relationship for outer‐sphere electron‐transfer reactions. A working mechanism consistent with the spectral and kinetic data is proposed for the aforesaid electron transfer reaction.
Bi[Se‐(2‐Me2NC6H4)]3: Single Source Precursor for Preparing Pure‐Phase, 2‐Dimensional Bismuth Selenide Films
Authors: P. D. Dharsana , Bisht Sheetal Kathayat , Majumder Saptak , Mondal Dipanjana , Singha Pintu , Bolegave Gaurav G. , Kamble Vinayak B. , Venugopal Ajay 
Published: November 2024

AbstractChemical vapor deposition using molecular compounds is a salient method to achieve high‐quality, uniform films comprising two‐dimensional flakes. In this communication, we present the synthesis and characterization of analytically pure single crystals of Bi[Se‐(2‐Me2NC6H4)]3, used as a single source precursor to grow thin films of bismuth selenide. The structural and morphological studies of the films were performed using powder X‐ray diffraction, Raman spectroscopy, scanning, and transmission electron microscopy, revealing a pure phase stoichiometry with two‐dimensional flakes of quintuple layers grown on glass, Si, and sapphire substrates. The deposited films on the glass surface show a near‐ideal Bi to Se stoichiometry of 1.84 and exhibit an ambient temperature resistivity of 30 mΩ.cm. When unevenly illuminated with a laser of 532 nm wavelength, it shows a photo‐thermoelectric (PTE) voltage generation with a response time of 2 seconds and an estimated Seebeck coefficient value of −128±6.6 μV/K, thus demonstrating its suitability for device applications in IoTs.
Enhancing the efficiency of hydrokinetic Savonius turbine with guiding walls
Authors: Ayadi Ahmed , Rabeh Nour , Nasraoui Haytham , Mosbahi Mabrouk , Driss Zied 
Published: November 2024

AbstractHydropower offers a means of generating electricity through the conversion of water flow's mechanical energy using rotors. The helical Savonius rotor is recognized as one of the most commonly employed rotor types. An approach employed to boost power output involves the utilization of guiding walls, positioned upstream of the Savonius rotor. In this specific study, an investigation is presented into a helical Savonius rotor equipped with an innovative deflector design composed of guiding walls in the form of NACA‐profiled plates. Ansys Fluent is used to simulate the water flow around the helical Savonius turbine and the guiding walls. The geometric parameters of this design of guiding walls are adjusted to identify the most efficient configuration. When examining all considered configurations, an improvement is noted in the maximum power coefficient, with a significant increase compared with a conventional configuration. In fact, the power coefficient could be improved by 44% using optimal dimensions of the guiding walls. The inclusion of the proposed guiding walls in conjunction with the optimized geometric parameters emerges as a strategy to enhance the rotor's power coefficient.