bluuebunny/crossref_metadata_2025_split huggingface dataset:
“COMPARISON OF A RAPID SEMI-QUANTITATIVE LATEX AGGLUTINATION SLIDE METHOD AGAINST QUANTITATIVE PARTICLE ENHANCED TURBIDIMETRIC IMMUNOASSAY FOR MEASUREMENT OF C- REACTIVE PROTEIN”
Authors: Trivedi Dr. Riyaben , Amer Abdulrahman , Patel Dr. Riddhi , Trivedi Pradip 
Published: June 2019

Serum C - reactive protein (CRP) is an acute phase marker in humans that is useful for the diagnosis and monitoring of inflammatory disease. CRP measurement also helps in differential diagnosis, in the management of neonatal septicaemia and meningitis where standard microbiological investigations are very much time-consuming. Reliable method (Automated particle enhanced turbidimetric immunoassay) are preferable for routine evaluation of human serum CRP levels. Using such expensive methods in health centres in rural areas is not possible. The aim of this to evaluate whether human CRP levels could be measured by rapid method (Latex agglutination slide method) and compared with reliable method (particle enhanced turbidimetric immunoassay).The study included 400 participants, who attended Shree Krishna Hospital, Karamsad, whose CRP levels were done by particle enhanced turbidimetric immunoassay method in Siemens Dimension Clinical Chemistry Analyzer, RxL and Xpand and compared by rapid method (Latex Agglutination slide method), that will be useful in health centres in rural areas where expensive instruments are not available. We used SPSS for data analysis and Endnote X7 for references management. In present study, out of 400 (217 male and 183 female) participants, we found 337 participants had positive CRP levels (≥0.3 mg/dl) and 63 participants had negative CRP levels (<0.3 mg/dl) by particle enhanced turbidimetric immunoassay method, whereas 303 had positive CRP levels (≥0.6mg/dl) and 97 had negative CRP levels (<0.6mg/dl) by Latex Agglutination slide method. The correlation was positive between two methods with (r = 0.764, P -value <0.0001). The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 89.9%, 100%, 100%, and 64.94%, respectively, for the Latex Agglutination slide method, and 100%, 64.9%, 89.91% and 100%, respectively, for the particle enhanced turbidimetric immunoassay method. Serum C- reactive protein (CRP) levels can be reliably measured using the particle enhanced turbidimetric immunoassay method, but it is expensive, so we can use Latex agglutination slide method in rural areas for primary diagnosis only.
Key Words: CRP, Latex Agglutination slide method, particle enhanced turbidimetric immunoassay method.
COMPARATIVE STUDY OF CORONARY ANGIOGRAPHIC FINDINGS BETWEEN DIABETIC AND NON DIABETIC PATIENTS
Authors: Sharma Mukesh Kumar , Kurmi Pradeep , Ameta Deepak , Chandan Chandra Bhanu 
Published: June 2019

Background: Coronary artery disease (CAD) is one of the most important manifestation of diabetes mellitus. Objectives: To assess the extent of CAD in diabetic and non diabetic patients undergoing coronary angiography. Materials and Methods: 793 patients with suspected CAD, 202 diabetics and 591 non-diabetics were enrolled in the study. All patients underwent coronary angiography. Results: Normal coronaries were more common in non diabetic patients. Age at first presentation in diabetics was earlier as compared to non-diabetics. Diabetic female patients presented as early as third decade of life. Single vessel involvement was significantly more in non diabetics [40.27%] as compared to diabetic patients[19.8%][P= <0.001], while there were statistically no significant differences in double vessel disease in both groups [P= 0.572]. Triple vessel disease were more common in diabetic than non diabetic patients [P= <0.001]. Left main disease, left circumflex coronary artery disease, coronary calcification, diffuse disease and CTOs were more common in diabetic patients. Conclusion: The severity and extent of CAD and incidence of triple vessel disease was significantly high in diabetics when compared to non diabetics.
Key Words: Coronary angiography; Coronary artery disease; Diabetes mellitus.
TO COMPARE THE EFFECTIVENESS OF DIFFERENT REGIMEN IN MANAGEMENT OF DERMATOPHYTE INFECTION AT TERTIARY CARE CENTER BIKANER RAJASTHAN
Authors: Babani Anil , Mehta R D , Ghiya B C , Soni Prasoon 
Published: June 2019

Background: The dermatophytoses are caused by a group of fungi known as ringworm or Tinea. These are from genera Microsporum, Trichophyton and Epidermophyton. Amongst Five to six species which are prevalent globally, Trichophyton rubrum happens to be the commonest.
Methods: A hospital based comparative prospective study included 600 patients of dermatophytoses having Tinea cruris and Tinea corporis attending the outpatient department of Dermatology, Venereology and Leprosy in PBM hospital Bikaner. Patients randomly divided into 3 groups - Group A received Tablet Fluconazole 150 mg per week plus Tablet Griseofulvin 10mg per kg bodyweight daily in two divided doses. Group B received Tablet Fluconazole 150 mg per week. Group C received Tablet Griseofulvin 10mg per kg body weight in two divided doses daily. Treatment to all groups was given for a period of 4 weeks. The data were analyzed on EPI-Info-6 Software.
Results: There were no statistically significant difference noted among three groups at 1st, 2nd & 3rd weeks and statistically significant difference in three groups was observed at 4th & 8th weeks follow-up.
Conclusion: The combination of Fluconazole and Griseofulvin is a bettar treatment option to treat tinea cruris and corporis as compared to mono therapy with Fluconazole or Griseofulvin.
Keywors: Fluconazole ,Griseofulvin, Mono Therapy, Dual therapy, Tinea Cruris and Tinea Corporis.
ASSESSMENT OF PERFORATER SPARING GLUTEAL FASCIOCUTANEOUS FLAP FOR SACRAL PRESSURE SORE
Authors: Satyapal Dr. Shyam Kumar 
Published: June 2019

Despite advances in reconstruction techniques, sacral pressure ulcers continue to present a challenge to the plastic surgeon.
Fasciocutaneous flaps are tissue flaps that include skin, subcutaneous tissue and the underlying fascia. Including the deep fascia with its prefascial and subfascial plexus enhances the circulation of these flaps. They can be raised without skin and are then referred to as fascial flaps. The present study was planned to evaluate the perforater Sparing Gluteal Fasciocutaneous flap for Sacral pressure sore.
The rotation Gluteal Fasciocutaneous flap for sacral pressure sore coverage have distinct advantage of rotation in the event of ulcer recurrence. The flap from the gluteal crease derives blood supply from the inferior gluteal artery perforator (IGAP) and reliably preserves the entire contralateral side as a donor site.
The author describe their approach of preserving and incorporating musculocutaneous perforators into the conventional rotation design.Data from 11 patients (8 men, 3 women; mean age [range 24-71] years old) whose sacral ulcers were closed with an IGAP flap between from Jan 2017 to Apr 2018 June were retrieved and reviewed. All patients were bedridden; 1 patient in a vegetative state with a diagnosis of Cerebro vascular accident was referred from a local clinic, 2 patients had pelvic bone fracture on long duration traction, and 2 patients had a history of Cervical injury leading to quadriplegia , and 6 patient have hemiplegia due to spinal injury . The average defect size was 110 cm(2) (range 78-134 cm(2)). The average flap size was 75.8 cm(2) (range 46-111 cm(2)).
After surgery, the patients' position was changed every 2 hours; patients remained prone or on their side for approximately 2 weeks until the flap was healed. After healing was confirmed, patients were discharged. Complications were relatively minor and included 1 donor site wound dehiscence that required wound reapproximation. No surgery-related mortality was noted; the longest follow-up period was 24 months.
The present study was planned in the Department of Plastic Surgery, Pulse Emergency Hospital, Patna, Bihar. Total 11 cases of the operated from Jan 2017 to Apr 2018 were included in the present study. All the patients were informed consents. The aim and the objective of the present study were conveyed to them. Approval of the institutional ethical committee was taken prior to conduct of this study.
The data generated from the present study concludes that the modified method we proposed is relatively simple and easy for reconstructing sacral sores, provides sufficient padding, and has little donor-site morbidity. Once sufficient padding is established in cases like this, a takeaway from this report would be to study the recurrence rates compared with the classic fasciocutaneous flap.
Keywords: Fasciocutaneous flaps, Sacral pressure, sore, etc.
EFFECT OF AZARDIRACHTA INDICA LEAF EXTRACT ON GILL OF FRESHWATER FISH, LABEO ROHITA
Authors: Geetha S. , Roopavathy Dr. J. , Sharon S. Abanah 
Published: June 2019

An investigation on the toxicity of biopesticidal plant Azardiracta indica aqueous leaf extracts to Labeo rohita. The LC50 value of Azardiracta indica aqueous leaf extracts was 1.1ml/lit respectively. The sub lethal concentration for Azardiracta indica was 0.11ml/lit and 0.33 ml/lit respectively. The fishes were exposed to the sub lethal concentration for a period of 15 days. At the end of 15th day the fishes were dissected and the gill were removed from exposed and control group fishes. The tissues were processed and sectioned at 4µm and then were stained with Haematoxylin- Eosin. The observation of the slides was done under light microscope at 40x magnification and photographed. The exposed group showed histopathological changes in the tissues, such as: shrunken and narrow secondary gill lamellae, mild to moderate infiltration of inflammatory cells in the primary and secondary gill lamellae. This result indicated that the aqueous extract of Azardiracta indica has considerable impact on the respiratory organ of fresh water fish, Labeo rohita.
Key words: Labeo rohita, Azardiracta indica, secondary lamellae
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF PALIPERIDONE
Authors: Gajera Kaushikbhai Ghanshyambhai , Raval Anil G 
Published: June 2019

Optimized orally disintegrating tablets (ODTs) containing Paliperidone were prepared by direct compression method. Two factors, three levels (32) full factorial design was used to optimize the effect of superdisintegrant (crospovidone; X1) and; Binder (PVP K30S; X2) on tablet properties. The prepared ODTs were characterized for their drug content, hardness, friability and wetting time. The optimized ODT formulation (P4) was evaluated in term of in vitro disintegration and dissolution. The manufactured ODTs were complying with the pharmacopeia guidelines regarding hardness, friability, weight variation and content. PVP K30 had a very slightly enhancing effect on tablets disintegration. However, the effects of both Crospovidone (X1) and PVP K30 (X2) on ODTs drug release (Y1) were significant (p < 0.05). Moreover, X1 exhibited significant effect on the disintegration time. Furthermore, the optimized ODTs formula showed 1 month stability, and in vitro disintegration time of this formula was about 33 s.
Key Words: Paliperidone, orally disintegrating tablets
A REVIEW ON COMPARITIVE STUDY ON SAFETY AND EFFECTIVENESS OF IV FERRIC CARBOXY MALTOSE VERSUS IRON SUCROSE IN PATIENTS WITH IRON DEFICIENCY ANAEMIA OF CKD
Authors: S LAYANA V. , MANJU RANI , GEORGE MATHEW , JOSEPH LINCY 
Published: June 2019

Deficiency of iron is one of the most common nutritional disorders in the society. Iron deficiency anemia is described as decreased production in red blood cells (RBCs) due to low body iron stores.Anemia commonly occurs in people with chronic kidney disease and it might begin to develop in the early stages and tends to worsen as disease progresses. Iron supplementation is mandatory in the majority of patients with renal disease, particularly in those receiving ESA therapy. Treatment with intravenous iron in some clinical situations could present some advantages over oral iron, such as faster and higher increases of hemoglobin (Hb) levels and body iron stores. Some modern formulations of intravenous iron have emerged as a safe and effective alternative for iron deficiency anaemia management. E.g.: iron sucrose. Ferric carboxy maltose is a parenteral iron dextran-free product and the first of the new agents approved for rapid and high-dose replenishment of depleted iron stores.
Keywords: Iron deficiency anaemia, chronic kidney disease, hemoglobin, iron sucrose, ferric carboxy maltose
El fenómeno del consumismo y sus desafíos para la mejora del medio ambiente
Authors: Reyes Rojas Germán Enrique 
Published: June 2019

La siguiente revisión documental representa acercamiento histórico, sobre los principales acontecimientos que dieron origen a la sociedad de consumo y los efectos que produce, en sus entornos a las personas en general, analizando principalmente el impacto ambiental que ha ejercido el consumismo en la sociedad, frente a la necesidad de satisfacer la necesidad del presente, es por ello por lo que a través de este trabajo pretendemos, proyectar posibles escenarios que permitan establecer algunos de los desafíos que enfrenta hoy por hoy el mundo moderno y todos los que en el habitamos, en pro del logro de la sostenibilidad ambiental, para este propósito se realizó este análisis, soportada en revisión documental (Artículos científicos y Libros), de autores relevantes en ambiente y desarrollo, que permita generar una información susceptible de ser utilizada por la comunidad académica. El proceso de análisis se llevó acabo en las siguientes fases. En una primera se esbozan conceptos y definiciones esenciales para la buena comprensión del texto sobre desarrollo sostenible y sostenibilidad ambiental. En la segunda, se abordan acciones para fomentar la sostenibilidad ambiental. Y por último los resultados obtenidos ofrecen un panorama general de las situaciones que sería necesario suplir en términos de desarrollo sostenible y equilibrio ecológico.
Garantía del debido proceso en el sistema penitenciario y carcelario para las personas recluidas en Colombia; España y Chile
Authors: Gutiérrez Jiménez Daniel Esteban , Quitumbo Ramírez Deicy , Osorio Londoño Nicolle Mitchelle , Agudelo Marín Sarai 
Published: June 2019

En el transcurso del siguiente documento, se podrá vislumbrar a través del ejercicio del derecho comparado, cómo ha sido la ejecución del debido proceso, enfatizando en la implementación del régimen penitenciario y carcelario colombiano; español y chileno; se plantean las discrepancias y similitudes de los ya mencionados países de estudio. Para realizar de manera exitosa ésta labor investigativa, se tendrán en cuenta tres ejes centrales que podrán facilitar dicha comparación, estos son, la norma, la jurisprudencia y la doctrina.
Similitudes y diferencias en la normatividad, jurisprudencia, y doctrina del derecho de petición de personas recluidas en centros penitenciarios de Colombia, México y Chile
Authors: Aguirre Arias Olga Bibiana , Perea Moreno Jimmy Enrique , Murillo Hurtado Ana Alicia 
Published: June 2019

En el transcurso del siguiente documento, se podrá vislumbrar a través del ejercicio del derecho comparado, cómo ha sido la ejecución del debido proceso, enfatizando en la implementación del régimen penitenciario y carcelario colombiano; español y chileno; se plantean las discrepancias y similitudes de los ya mencionados países de estudio. Para realizar de manera exitosa ésta labor investigativa, se tendrán en cuenta tres ejes centrales que podrán facilitar dicha comparación, estos son, la norma, la jurisprudencia y la doctrina.
Justicia y jueces en un Estado sitiado por la corrupción
Authors: Gallego Ramírez William Giovanni 
Published: June 2019

Un momento de crisis institucional sin precedentes en la historia de Colombia atraviesan los diferentes estamentos de la estructura del Estado en la última década, y en este se sitúa un periodo oscuro que arroja saldo alarmante en cuanto a servidores públicos condenados, enjuiciados y disciplinados por casos de corrupción. En dicho lapso se tiene cuenta de un exministro de agricultura con fallo en firme de 17 años de prisión al ser hallado responsable de delitos contra la administración pública, decenas de ex congresistas purgando penas intramurales también por comprobadas faltas a la función pública asociadas a prácticas corruptas conjugadas con el actuar de grupos paramilitares, y se despliega un desconsolador panorama que a la fecha reporta: tres expresidentes de la Corte Suprema de Justicia procesados por su presunta participación en un cartel de fallos judiciales (Leónidas Bustos, Francisco Ricaurte y Camilo Tarquino), uno de ellos con detención preventiva (Bustos), articulados con otros magistrados del mismo tribunal y, lo más contradictorio, con el propio fiscal anticorrupción, para favorecer congresistas investigados, además del inédito caso del magistrado José Ignacio Pretelt Chaljub de la Corte Constitucional, quien ostenta el deshonroso record de ser el primer magistrado de las altas cortes con un proceso penal abierto ante la Corte Suprema, después de haber sido remitido su expediente por la comisión de acusaciones del senado, que tras un año de investigación encontrara elementos para dar inicio a la acción penal.
Desarrollo jurisprudencial de la Corte Constitucional frente a la objeción de conciencia en la prestación del servicio
Authors: Álvarez Molina Angie Marcela , Ávila Sánchez Valentina , Mejía Grajales Camila Alejandra 
Published: June 2019

En la presente investigación se busca realizar un análisis de dos derechos de rango constitucional los cuales son: objeción de conciencia (artículo 18) y prestación del servicio militar obligatorio (artículo 216), dichos derechos generan choques en el ejercicio de su cumplimiento, puesto que el segundo derecho anteriormente mencionado se encuentra consagrado como una obligación constitucional para todos los varones colombianos mayores de dieciocho años de edad, lo cual puede llegar a vulnerar en algunas ocasiones la libertad de conciencia. Según lo expuesto “Una Constitución justa aspira armonizar la libertad de cada individuo con la de los demás” (Sandel, 2011, p.159), lo que se pretendía con la expedición de la Constitución de 1991 era generar una importante transición buscando garantizar y amparar la libertad de expresión y asimismo establecerse como un Estado laico asegurando la libertad de culto o de conciencia.En virtud de lo anterior, el problema de investigación radica principalmente en la protección que le ha dado la Corte Constitucional a lo largo del tiempo viéndose reflejado en su jurisprudencia. Por tanto, se construye una línea jurisprudencial identificando cuál ha sido la tendencia de la Corte Constitucional frente a la objeción de conciencia y la prestación del servicio militar obligatorio; acudiendo a técnicas de construcción de línea jurisprudencial en la que se elabora la depuración de sentencias y así dar paso a la elaboración del nicho citacional y los puntos nodales, tal y como lo plantea Diego Eduardo López Medina en su libro “El derecho de los jueces”. A lo largo de esta investigación se hace mención a diferentes sentencias adoptando así una posición distinta por parte de la Corte Constitucional después del año 2009 en la sentencia C-728 la cual ha generado un cambio de precedente, protegiendo y respetando el derecho a objetar conciencia frente al servicio militar. El cambio de precedente se evidencia de manera clara a través de la construcción y el análisis de los puntos nodales y el nicho citacional.
IMPROVING OF CREATIVE THINKING AND LEARNING OUTCOMES PHYSICS THROUGH CREATIVE PROBLEM SOLVING (CPS) APPROACHES
Authors: Thayyib Sulaeha 
Published: June 2019

The objective in this research to describing implementation of learning physics using the approach Creative Problem Solving (CPS) to improve creative thinking skills and student’s achievement in class X IPA-1 SMAN 1 Pangsid. The research method applied is Classroom Action Research (CAR) through two learning cycles; each cycle consisted by planning, implementation, observation and reflection. The results showed that learning physics with CPS approach can improve student’s ability to think creatively. After learning undertaken by the CPS approach increased students ability to think creatively and achievement.
This is evidenced by: (1) Increasing the number of students who pass out of 12 person in the first cycle to 29 person in the second cycle with an average of 77,39 learning outcomes. N-gainin the first cycle of 0.19 is included in the category of low-and N-gain in the second cycle of 0.30 is included in the medium category, (2) Activity group average student in the learning process are included in the category Activities Fair increased to High Activity category, and (3) The use of creative thinking of students in the first cycle an enough increased to a high in the second cycle. Creative thinking ability of students in teaching physics to provide benefits in solving problems in the community.
Cluster randomised feasibility trial to test the routine use of the Needs Assessment Tool: Cancer (NAT:-C) in primary care to reduce unmet patient and carer needs and determine the feasibility of a definitive trial
Authors: Clark Joseph , Amoakwa Elvis , Blenkinsopp John , Currow David , Farrin Amanda , Foy Robbie , Macleod Una , Meads David , Wright-Hughes Alexandra , Johnson Miriam 
Published: June 2019

BackgroundPeople with cancer commonly have unidentified palliative care needs. The NAT-C is a validated tool to identify and triage unmet needs.AimTo assess the feasibility and acceptability of a primary care cRCT of the NAT-C: 1) recruiting four GP-practices and 40–60 patients, 2) uptake of NAT-C, 3) questionnaire completion 4) acceptability of measures.MethodA non-blinded cRCT with process evaluation. Patients with active cancer were identified through cancer registries or opportunistically. Carers were nominated by patient-participant. Participants completed measures at baseline, 1, 3, and 6 months. Patients booked a 20-minute GP-assessment post-baseline. Patients, carers, and GP practice staff participated in interviews and focus groups.ResultsFive GP practices were approached, four recruited and trained in the use of the NAT-C. Practices were randomised (1:1) to provide a consultation with a known NAT-C trained clinician, or a clinician as usual. Forty-seven patients and 17 carers were recruited. Process evaluation informed refinement of study invitations. Recruitment rate showed a trial was feasible. Forty-three (94%) patients received a study appointment, 42/43 (95%) attended and 32/43 (76%) a NAT-guided consultation. The proposed primary outcome measure (Supportive Care Needs Survey) was completed by 43 (91%) at 1 month and the proportion with ≥1 moderate–severe unmet need fell from 72% (baseline) to 45%. Fifteen patient interviews and four focus groups with GP practices were conducted. Participants supported the definitive trial and found measures acceptable.ConclusionA definitive cRCT is feasible based on the recruitment rate, intervention uptake, and data collection.