bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Fibrinogen Depletion and Symptomatic Intracranial Hemorrhage After Reperfusion Therapy
Authors: Yan Shenqiang , Zhang Xuting , Zhang Ruoxia , Xu Jinjin , Lou Min 
Published: August 2019

Background and Purpose—
We aimed to thoroughly investigate the relationship between early fibrinogen depletion and symptomatic intracranial hemorrhage (sICH) in patients receiving reperfusion therapy including intravenous thrombolysis (IVT) with or without endovascular thrombectomy (EVT).

Methods—
This study included 1135 stroke patients with baseline and follow-up fibrinogen levels at 2 hours after the beginning of alteplase infusion for those with IVT only or immediately after the end of EVT for those with combined IVT and EVT. Patients received alteplase up to 9 hours after the onset or on awakening based on automated perfusion imaging. sICH was ascertained using ECASS II (The Second European-Australasian Acute Stroke Study) criteria. Δfibrinogen was calculated as follow-up fibrinogen minus baseline fibrinogen.

Results—

In patients with IVT only, baseline fibrinogen level was 3.36±0.94 g/L and decreased to 2.47±0.80 g/L at 2 hours after the beginning of alteplase infusion. In patients with IVT followed by EVT, baseline fibrinogen level was 3.35±0.82 g/L and decreased to 2.52±0.83 g/L immediately after the end of EVT. sICH was observed in 44 (3.9%) patients. The extent of Δfibrinogen was associated with sICH in patients with IVT only (odds ratio, 1.929; 95% CI, 1.402–2.654;
P
<0.001) and in those with IVT followed by EVT (odds ratio, 1.765; 95% CI, 1.135–2.743;
P
=0.012).

Conclusions—
An early decrease in fibrinogen levels was related to sICH after reperfusion therapy with alteplase. More fibrin-specific thrombolytic agents are warranted to be tested in acute ischemic stroke patients.

Clinical Trial Registration—

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT03367286.
The Use of Glossaries by the Translators of the Septuagint
Authors: Yardney Sarah 
Published: August 2019

Abstract
This article proposes that the Septuagint translators made and used limited Hebrew-Greek glossaries. While these documents are not extant, this proposal explains the perplexing inconsistency of lexemic knowledge in the Septuagint of Samuel, and suggests a possible resolution to the scholarly debate regarding the translators’ use of the Pentateuch as a lexicon. Evidence of bilingual word lists from the ancient Near East and the Greco-Roman world supports the plausibility of the Septuagint translators having such tools as well.
Sensitivity of Lake-Effect Cloud Microphysical Processes to Ice Crystal Habit and Nucleation during OWLeS IOP4
Authors: Gaudet Lauriana C. , Sulia Kara J. , Yu Fangqun , Luo Gan 
Published: August 2019

AbstractIce crystal habit significantly impacts ice crystal processes such as growth by vapor deposition. Despite this, most bulk microphysical models disregard this natural shape effect and assume ice to grow spherically. This paper focuses on how the evolution of ice crystal shape and choice of ice nucleation parameterization in the adaptive habit microphysics model (AHM) influence the lake-effect storm that occurred during intensive observing period 4 (IOP4) of the Ontario Winter Lake-effect Systems (OWLeS) field campaign. This localized snowstorm produced total accumulated liquid-equivalent precipitation amounts up to 17.92 mm during a 16-h time period, providing a natural laboratory to investigate the ice–liquid partitioning within the cloud, various microphysical process rates, the accumulated precipitation magnitude, and its associated spatial distribution. Two nucleation parameterizations were implemented, and aerosol data from a size-resolved advanced particle microphysics (APM) model were ingested into the AHM for use in parameterizing ice and cloud condensation nuclei. Simulations allowing ice crystals to grow nonspherically produced 1.6%–2.3% greater precipitation while altering the nucleation parameterization changed the type of accumulating hydrometeors. In addition, all simulations were highly sensitive to the domain resolution and the source of initial and boundary conditions. These findings form the foundational understanding of relationships among ice crystal habit, nucleation parameterizations, and resultant cold-season mesoscale precipitation within detailed bulk microphysical models allowing adaptive habit.
Validation of the Maxillary Sinus Roof as a Landmark for Navigating the Pediatric Skull Base
Authors: Evans Sean S. , Banks Catherine , Richman Joshua , Woolley Audie , Cho Do Yeon , Woodworth Bradford 
Published: August 2019

Objective: To define a new anatomic relationship in pediatric sinus surgery, assessing the maxillary roof as a constant safe landmark to avoid skull base injury in the pediatric population. Study Design: Retrospective analysis. Setting: Tertiary care children hospital. Subjects and Methods: A retrospective analysis was performed of all computed tomography scans of the sinuses and facial bones at the emergency department of a tertiary children’s hospital over the course of a year. Radiographic measurements included the lowest cribriform plate and planum sphenoidale (PS) heights, or posterior skull base when not yet pneumatized, as well as the highest maxillary roof height. The nasal floor was used for reference. Statistics were performed via Shapiro-Wilks test with a P-value of .05 indicating statistical significance. Results: Three hundred and seven unique scans were reviewed (38.9% female; n = 122; P = .58). Age stratification was based on previously described sinus growth patterns. In all patients, the maximum maxillary height was inferior to the lowest measured cribriform lamella and PS ( P < .001; CI, 98.5%-99%). Inter- and intrarater reliability and accuracy were verified through blinded review and re-review (ρ = .99 and .98 respectively, P ≤ .001). The validity of sole coronal measurements due to incomplete sagittal reformatting was also confirmed (ρ = 1.00, P ≤ .001). Conclusion: Despite variation in sinus growth and development in children, the current study demonstrated the validity of the maxillary sinus roof as a constant safe landmark in the pediatric population, offering a novel anatomic relationship for teaching safety in performing pediatric sinus surgery. Level of Evidence: 4
Analysis of Foreign Direct Investment and Economic Growth in Nigeria: Application of Spatial Econometrics and Fully Modified Ordinary Least Square (FMOLS)
Authors: Olofin Olabode Philip , Aiyegbusi Oluwole Oladipo , Adebayo Abayomi Ayinla 
Published: August 2019

Based on the controversy surrounding the determinants of foreign direct investment (FDI) inflow from one country to another and the suggestion that inflow of FDI might be a result of countries’ locations, this study therefore revisits the determinants of FDI and economic growth by testing for the roles of country’s location in the determination of the inflow of FDI to Nigeria. Unlike other studies, this study finds that countries’ locations do not play any significant role in determining FDI inflow to Nigeria. The study, therefore, employs fully modified ordinary least square (FMOLS) to examine the determinants of FDI in Nigeria. The FMOLS results show that FDI, manufacturing sector, tax revenue, financial development, health expenditure, net trade and human capital have a positive relationship with income growth. These results were statistically significant except for tax revenue, net trade and human capital. These results support the argument that these variables are important determinants of economic growth. The article also finds a negative and statistically significant relationship among FDI, income growth, import and capital formation. These results are in conformity with economic theory in the sense that import of goods and services constitutes a leakage in the economy. Negative impact of capital formation and security could be associated with the prevailing high level of corruption, sharing of security votes and misappropriation of funds among the public officials in Nigeria. JEL Codes: F23, F26, F21, H24
Core services of intensive case management for people with mental illness: A network analysis
Authors: Suzuki Kota , Yamaguchi Sosei , Kawasoe Yasunari , Nayuki Kazumi , Aoki Tsutomu , Hasegawa Naomi , Fujii Chiyo 
Published: August 2019

Background: In intensive case management (ICM), users receive a wide variety of services of varying content, which makes it difficult to understand the global features of ICM programs. Aims: The aim of this study was to examine the features of ICM programs using network analysis. Methods: A total of 233 ICM users in two Japanese medical institutions were recruited to participate. All received services were recorded for 2 months. In the network analysis, nodes represented types of ICM services and edges between two nodes depicted when over 5% of participants received both types of services. Results: We found high centrality values for ‘H5. Hospital-based counseling’, ‘O13. Outreach support for mental health medications’, ‘H13. Hospital-based support for mental health medication’, ‘T5. Counseling via telecommunication’, ‘H3. Hospital-based coordination of services in the medical institution’ and ‘T2. Coordination of services with other institutions via telecommunication’. These results indicated that these services were associated with various other types of services. Social functioning was related to ‘O13. Outreach support for mental health medication’, whereas need for ICM was related to ‘H13. Hospital-based support for mental health medications’, ‘T5. Counseling via telecommunication’ and ‘T2. Coordination of services with other institutions via telecommunication’ Conclusion: Based on these findings, we speculated that there are at least five types of core services in ICM: regular face-to-face contact, outreach services, hospital-based services, easy contacts and coordination. These findings clarified the features of ICM programs, which may help improve the understanding of case managers’ practice.
Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review
Authors: Zhang Chen , Qian Han-Zhu , Liu Yu , Vermund Sten H 
Published: August 2019

Background: With the rapidly-increased HIV epidemic among men who have sex with men worldwide, the effectiveness of voluntary medical male circumcision as the tool of HIV prevention still remains undetermined. Purpose: In the current study, we conducted a systematic review and meta-analysis to assess the association between voluntary medical male circumcision and HIV risk among men who have sex with men. Methods and Conclusion: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline, we conducted a comprehensive literature search through multiple databases. A total of 37 articles/abstracts were included in the analysis. We employed random-effects models and subgroup analyses based upon key study characteristics derived from empirical studies. A total of 117,293 men who have sex with men were included in the meta-analysis, and no randomized control trials have been identified. The odds of being HIV positive were 7% lower among men who have sex with men who were circumcised than among men who have sex with men who were uncircumcised (adjusted odds ratio, 0.93; 95% confidence interval, 0.88–0.99). The evidence for the potential protective effect of voluntary medical male circumcision was stronger among men who have sex with men in Asia and Africa (adjusted odds ratio, 0.62; 95% confidence interval, 0.53–0.73). Our meta-analyses may suggest a protective effect of voluntary medical male circumcision against HIV infection among men who have sex with men, especially in settings like Asia/Africa.
The α-emitter astatine-211 targeted to CD38 can eradicate multiple myeloma in a disseminated disease model
Authors: O’Steen Shyril , Comstock Melissa L. , Orozco Johnnie J. , Hamlin Donald K. , Wilbur D. Scott , Jones Jon C. , Kenoyer Aimee , Nartea Margaret E. , Lin Yukang , Miller Brian W. , Gooley Theodore A. , Tuazon Sherilyn A. , Till Brian G. , Gopal Ajay K. , Sandmaier Brenda M. , Press Oliver W. , Green Damian J. 
Published: August 2019

Key Points211At targeted to CD38 eliminates MM cell clones in murine models of low-burden disease. 211At deposits ≥500 times more energy than β-emitters and provides a mechanism of uniform cell kill unique among MM therapeutics.
Switching to Degludec From Other Basal Insulins Is Associated With Reduced Hypoglycemia Rates: A Prospective Study
Authors: Fadini Gian Paolo , Feher Michael , Hansen Troels Krarup , de Valk Harold W , Koefoed Mette Marie , Wolden Michael , Zimmermann Esther , Jendle Johan 
Published: August 2019

AbstractContextObservational studies of insulin degludec (degludec) with hypoglycemia events prospectively recorded are lacking.ObjectiveTo evaluate the safety and effectiveness of degludec in patients with type 1 diabetes (T1D) or type 2 diabetes (T2D) switching from other basal insulins in routine care.DesignResults From Real-World Clinical Treatment With Tresiba® was a multinational, multicenter, prospective, observational, single-arm study comprising a 4-week baseline period (preswitch basal insulin) and 12-month follow-up (degludec).SettingRoutine clinical practice.Patients or Other ParticipantsInsulin-treated patients (≥18 years) with T1D (n = 556) or T2D (n = 611) with treatment plans to initiate degludec.InterventionsSwitching to degludec from other basal insulins.Main Outcome MeasureChange from baseline in number of overall hypoglycemic events recorded in patient diaries.ResultsIn T1D, the 12-month follow-up/baseline rate ratios (95% CI) of overall [0.80 (0.74 to 0.88)], nonsevere [0.83 (0.76 to 0.91)], severe [0.28 (0.14 to 0.56)], and nocturnal [0.61 (0.50 to 0.73)] hypoglycemia suggested significantly lower hypoglycemia rates with degludec (all Ps < 0.001). At 12 months, HbA1c, fasting plasma glucose (FPG), and basal insulin dosage decreased significantly. Body weight increased, and treatment satisfaction improved significantly. In T2D, the hypoglycemia rate ratios were overall [0.46 (0.38 to 0.56)], nonsevere [0.53 (0.44 to 0.64)], and nocturnal [0.35 (0.20 to 0.62)] (all Ps < 0.001; too few events for analysis of severe hypoglycemia). At 12 months, HbA1c and FPG decreased significantly. Body weight and insulin dosages remained unchanged, and treatment satisfaction was significantly improved.ConclusionsIn a routine clinical care setting, switching to degludec from other basal insulins was associated with significantly lower rates of hypoglycemia, improved glycemic control, and treatment satisfaction in patients with T1D or T2D.
Une société sans pères peut-elle être féministe ?
Authors: Verjus Anne 
Published: August 2019

PrécisL'empire des Nairs, publié en 1793, imagine une société dans laquelle mariage et paternité ont été abolis. L'amour et la sexualité y sont libres pour les deux sexes. Les femmes sont payées par l'Etat pour s'occuper des enfants. Les hommes, libérés de toute responsabilité paternelle, placent leur énergie au service de la science ou de la guerre. Lawrence, l'auteur de cette utopie qui connaît de multiples éditions en allemand, anglais et français, se réclame du féminisme. Mais une société qui charge exclusivement les femmes du soin des enfants peut-elle être considérée comme féministe ? Promouvoir l'amour libre, à une époque où l'on ne maîtrise pas la contraception, n'est-il pas une vision androcentrée de l'égalité des sexes ? On répond à ces questions en comparant les propositions de Lawrence avec la législation française et les romans féministes anglais sur le mariage et la paternité dans l'espace transnational de la cause des femmes des années 1790.The Empire of the Nairs, first published in 1793, imagines a society in which marriage and paternity would be abolished. Love and sexuality would be free for both sexes. Girls and boys would receive the same education. Mothers, not fathers, would give their name to children. Women would be paid by the state for taking care of children, while daughters and sons would inherit from the maternal lineage. Fathers, by contrast, having no familial obligations, would reserve their sexual energy for love, genius, or war. Lawrence, the English author of this utopia, considered himself a feminist. But how can a society that places the entire burden of raising children on women be feminist? Wasn't advocating free love, in a time with no contraception, an androcentric point of view? Only by examining the way French legislators and English feminist novelists during the 1790s thought about marriage and paternity can we answer these questions.
When the Republic Came for the Nuns
Authors: Sachs Miranda 
Published: August 2019

AbstractDuring its first decades the Third Republic's relationship with the Catholic Church soured. While the Republic notoriously recast itself as a secular regime through removing clerics from the classroom, laicization also drove the development of public welfare. By examining the case of ouvroirs, charitable ateliers run by female religious orders to train and employ young women, this article explores the consequences of new ideas about welfare for working-class girlhood. In the context of rising anticlericalism, the Republic mobilized labor law and sent labor inspectors to scrutinize the nuns' treatment of their charges. The Republic's efforts to regulate these spaces represent a transformation in its treatment of girlhood, a recognition that girls' care could not be left to the private sphere. Instead, not only was it the Republic's responsibility to protect these girls, but this protection had a larger, societal imperative.Durant ses premières décennies, les relations entre la Troisième République et l'Eglise catholique se détérioraient. Si l'écartement du clergé des salles de classe est un exemple notoire de la laïcisation républicaine, l'avènement de l'assistance sociale n'en est pas moins un. En examinant le cas des « ouvroirs », ces ateliers dirigés par des religieuses afin de former et employer des jeunes filles, cet article s'intéresse aux conséquences des conceptions nouvelles de l'assistance sociale pour les filles de la classe ouvrière. Alors que l'anticléricalisme devient de plus en plus présent, la République fait appel aux lois sur le travail et demande aux inspecteurs de vérifier le bon fonctionnement des actions entreprises par les religieuses. Cet effort croissant de la République pour réglementer ces locaux marque un refus de laisser le sort des jeunes filles à la sphère privée ainsi qu'une transformation de la politique sur l'enfance. Quand la République accepte la responsabilité de protéger ces filles des ouvroirs, la protection de l'enfance devient un devoir politique.
Ultrasound-derived Biceps Femoris Long Head Fascicle Length: Extrapolation Pitfalls
Authors: FRANCHI MARTINO V. , FITZE DANIEL P. , RAITERI BRENT J. , HAHN DANIEL , SPÖRRI JÖRG 
Published: August 2019

ABSTRACT

Purpose
This study aimed to compare biceps femoris long head (BFlh) fascicle length (Lf) obtained with different ultrasound-based approaches: 1) single ultrasound images and linear Lf extrapolation, 2) single ultrasound images and one of two different trigonometric equations (termed equations A and B), and 3) extended field of view (EFOV) ultrasound images.

Methods
Thirty-seven elite alpine skiers (21.7 ± 2.8 yr) without a previous history of hamstring strain injury were tested. Single ultrasound images were collected with a 5-cm linear transducer from BFlh at 50% femur length and were compared with whole muscle scans acquired by EFOV ultrasound.

Results
The intrasession reliability (intraclass correlation coefficient [ICC3,k]) of Lf measurements was very high for both single ultrasound images (i.e., Lf estimated by linear extrapolation; ICC3,k = 0.96–0.99, SEM = 0.18 cm) and EFOV scans (ICC3,k = 0.91–0.98, SEM = 0.19 cm). Although extrapolation methods showed cases of Lf overestimation and underestimation when compared with EFOV scans, mean Lf measured from EFOV scans (8.07 ± 1.36 cm) was significantly shorter than Lf estimated by trigonometric equations A (9.98 ± 2.12 cm, P < 0.01) and B (8.57 ± 1.59 cm, P = 0.03), but not significantly different from Lf estimated with manual linear extrapolation (8.40 ± 1.68 cm, P = 0.13). Bland–Altman analyses revealed mean differences in Lf obtained from EFOV scans and those estimated from equation A, equation B, and manual linear extrapolation of 1.91 ± 2.1, 0.50 ± 1.0, and 0.33 ± 1.0 cm, respectively.

Conclusions
The typical extrapolation methods used for estimating Lf from single ultrasound images are reliable within the same session, but not accurate for estimating BFlh Lf at rest with a 5-cm field of view. We recommend that EFOV scans are implemented to accurately determine intervention-related Lf changes in BFlh.
Comparison of arthroscopic and open reduction of conservatively irreducible dislocated hips of children
Authors: Presch C. , Eberhardt O. , Wirth T. , Fernandez F. F. 
Published: August 2019

Purpose Children with sonographic grade IV hip dysplasia according to Graf and with failed conservative treatment usually need surgical reduction afterwards. Surgical reduction of the hip can lead to severe complications, the occurrence of residual acetabular dysplasia, osteonecrosis, redislocation and other postoperative complications. This paper investigates whether arthroscopic reduction is a promising alternative to open reduction. Methods We retrospectively examined 66 patients (78 hips) who were not older than two years at the first time of surgery. Arthroscopic reduction was performed on 17 children (19 hips) and open reduction on 49 children (59 hips). Patient records were used to determine redislocation, postoperative complication and residual dysplasia. Radiographs were used to determine Tönnis classification for osteonecrosis and pathological acetabular (AC) angle for residual dysplasia. We considered data up to a two-year follow-up. Statistical evaluation was performed with binary logistic regression. Results After arthroscopic reduction, 6% showed osteonecrosis, compared with 20% with open reduction (p = 0.334). Redislocation was not observed after arthroscopic reduction but for 29% after open reduction (p = 0.005). An improvement of femoral head coverage was achieved with residual dysplasia of 23.5% after arthroscopic reduction, compared with 62% after open reduction (p = 0.002). Conclusion The arthroscopic procedure represents a meaningful alternative to the open procedure due to a lower complication rate, a safe setting, a lower rate of residual dysplasia, no observed redislocation and occurrence of osteonecrosis only once in the arthroscopic group of developmental dysplasia of the hip. The arthroscopic procedure should be tested in further studies and in other clinics in order to broaden the empirical base. Level of Evidence Level III (retrospective cohort study)