bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medial Temporal Encephalocele and Medically Intractable Epilepsy: A Tailored Inferior Temporal Lobectomy and Case Report
Authors: Mikula Anthony L , ReFaey Karim , Grewal Sanjeet S , Britton Jeffrey W , Van Gompel Jamie J 
Published: May 2019

Abstract

BACKGROUND AND IMPORTANCE
Temporal lobe encephaloceles are increasingly recognized as a potential cause of medically refractory epilepsy and surgical treatment has proven effective. Resection of the encephalocele and associated cortex is often sufficient to provide seizure control. However, it is difficult to determine the extent of adjacent temporal lobe that should be resected. We present a case report and our technique of a tailored inferior temporal pole resection.

CLINICAL PRESENTATION
A 32-yr-old man with an 11-yr history of medically refractory epilepsy. Prolonged electroencephalography (EEG) revealed frequent left and rare right frontotemporal sharp waves. Numerous seizures were captured with EEG, all of which originated from the left temporal region. Statistical parametric mapping (SPM) subtraction ictal–interictal SPECT coregistered with magnetic resonance imaging (MRI) (SISCOM) demonstrated ictal hyperperfusion in the anterior left temporal lobe. MRI showed 2 encephaloceles in the left anterior temporal lobe with the accompanying bony defects in the floor of the middle cranial fossa apparent on the computed tomography scan. The patient underwent left temporal craniotomy with intraoperative electrocorticography, resection of the encephaloceles, and a tailored inferior temporal lobectomy (IFTL) and repair of the middle fossa defects. At 7 mo follow up he reported seizure-freedom since surgery.

CONCLUSION
Resection of temporal encephalocele and adjacent cortex is safe and effective procedure for select patients with medically refractory epilepsy. This video demonstrates our technique which provides a more standardized approach to the resection.
A Bidirectional Network for Appetite Control in Larval Zebrafish
Authors: Wee Caroline Lei , Song Erin Yue , Johnson Robert Evan , Ailani Deepak , Randlett Owen , Kim Jiyoon , Nikitchenko Maxim , Bahl Armin , Yang Chao-Tsung , Ahrens Misha B. , Kawakami Koichi , Engert Florian , Kunes Samuel 
Published: May 2019

ABSTRACTMedial and lateral hypothalamic loci are known to suppress and enhance appetite, respectively, but the dynamics and functional significance of their interaction have yet to be explored. Here we report that, in larval zebrafish, primarily serotonergic neurons of the ventromedial caudal hypothalamus (cH) become increasingly active during food deprivation, whereas activity in the lateral hypothalamus (LH) is reduced. Exposure to food sensory and consummatory cues reverses the activity patterns of these two nuclei, consistent with their representation of opposing internal hunger states. Baseline activity is restored as food-deprived animals return to satiety via voracious feeding. The antagonistic relationship and functional importance of cH and LH activity patterns were confirmed by targeted stimulation and ablation of cH neurons. Collectively, the data allow us to propose a model in which these hypothalamic nuclei regulate different phases of hunger and satiety and coordinate energy balance via antagonistic control of distinct behavioral outputs.
4-oxo-2-nonenal Adducts In HDL Are Elevated In Familial Hypercholesterolemia: Identification Of Modified Sites And Functional Consequences
Authors: May-Zhang Linda S. , Yermalitsky Valery , Melchior John T. , Morris Jamie , Tallman Keri A. , Borja Mark S. , Pleasent Tiffany , Venkataraman Amarnath , Yancey Patricia G. , Davidson W. Sean , Linton MacRae F. , Davies Sean S. 
Published: May 2019

ABSTRACTThe lipid aldehyde 4-oxo-2-nonenal (ONE) derived from peroxidation of n-6 polyunsaturated fatty acids and generated in parallel to 4-hydroxynonenal (HNE) is a highly reactive protein crosslinker. Crosslinking of proteins in high-density lipoprotein (HDL) by lipid peroxidation products causes HDL dysfunction and contributes to atherogenesis. While HNE is relatively well studied, the relevance of ONE in atherosclerosis and in modifying HDL has not been examined. In the present study, we found a significant increase in ONE-ketoamide (lysine) adducts in HDL derived from patients with familial hypercholesterolemia (FH) (1620 ± 985.4 pmol/mg) compared to healthy controls (664 ± 219.5 pmol/mg). ONE crosslinked apoA-I on HDL at a concentration of >3 mol ONE per 10 mol apoA-I (0.3 eq), which is 100-fold lower than HNE but comparable to the potent protein crosslinker, isolevuglandin. ONE-modified HDL partially inhibited the ability of HDL to protect against LPS-induced TNFα and IL-1β mRNA expression in murine macrophages. At 3 eq., ONE dramatically decreased the ability of apoA-I to exchange from HDL, from ~46.5% to only ~18.4% (P<0.001). Surprisingly, ONE-modification of HDL or apoA-I did not alter macrophage cholesterol efflux capacity. LC/MS/MS analysis showed modification of Lys12, Lys23, Lys96, and Lys226 of apoA-I by ONE-ketoamide adducts. Compared to other dicarbonyl scavengers, pentylpyridoxamine (PPM) was most efficacious at blocking ONE-induced protein crosslinking in HDL. Our studies show that ONE HDL adducts are elevated in FH who have severe hypercholesterolemia and atherosclerosis and causes HDL dysfunction. We demonstrate the use of PPM in preferentially scavenging ONE in biological systems.
Conserved epigenetic regulatory logic infers genes governing cell identity
Authors: Shim Woo Jun , Sinniah Enakshi , Xu Jun , Vitrinel Burcu , Alexanian Michael , Andreoletti Gaia , Shen Sophie , Sun Yuliangzi , Balderson Brad , Boix Carles , Peng Guangdun , Jing Naihe , Wang Yuliang , Kellis Manolis , Tam Patrick P L , Smith Aaron , Piper Michael , Christiaen Lionel , Nguyen Quan , Bodén Mikael , Palpant Nathan J. 
Published: May 2019

SUMMARYDetermining genes orchestrating cell differentiation in development and disease remains a fundamental goal of cell biology. This study establishes a genome-wide metric based on the gene-repressive tri-methylation of histone 3 lysine 27 (H3K27me3) across hundreds of diverse cell types to identify genetic regulators of cell differentiation. We introduce a computational method, TRIAGE, that uses discordance between gene-repressive tendency and expression to identify genetic drivers of cell identity. We apply TRIAGE to millions of genome-wide single-cell transcriptomes, diverse omics platforms, and eukaryotic cells and tissue types. Using a wide range of data, we validate TRIAGE’s performance for identifying cell-type specific regulatory factors across diverse species including human, mouse, boar, bird, fish, and tunicate. Using CRISPR gene editing, we use TRIAGE to experimentally validateRNF220as a regulator ofCionacardiopharyngeal development andSIX3as required for differentiation of endoderm in human pluripotent stem cells. A record of this paper’s Transparent Peer Review process is included in the Supplemental Information.
Clustering in the presence of side information: a non-linear approach
Authors: Abin Ahmad Ali 
Published: May 2019

Purpose
Constrained clustering is an important recent development in clustering literature. The goal of an algorithm in constrained clustering research is to improve the quality of clustering by making use of background knowledge. The purpose of this paper is to suggest a new perspective for constrained clustering, by finding an effective transformation of data into target space on the reference of background knowledge given in the form of pairwise must- and cannot-link constraints.

Design/methodology/approach
Most of existing methods in constrained clustering are limited to learn a distance metric or kernel matrix from the background knowledge while looking for transformation of data in target space. Unlike previous efforts, the author presents a non-linear method for constraint clustering, whose basic idea is to use different non-linear functions for each dimension in target space.

Findings
The outcome of the paper is a novel non-linear method for constrained clustering which uses different non-linear functions for each dimension in target space. The proposed method for a particular case is formulated and explained for quadratic functions. To reduce the number of optimization parameters, the proposed method is modified to relax the quadratic function and approximate it by a factorized version that is easier to solve. Experimental results on synthetic and real-world data demonstrate the efficacy of the proposed method.

Originality/value
This study proposes a new direction to the problem of constrained clustering by learning a non-linear transformation of data into target space without using kernel functions. This work will assist researchers to start development of new methods based on the proposed framework which will potentially provide them with new research topics.
A hybrid genetic algorithm for multi-objective flexible job shop scheduling problem considering transportation time
Authors: Huang Xiabao , Yang Lixi 
Published: May 2019

Purpose
Flexible job-shop scheduling is significant for different manufacturing industries nowadays. Moreover, consideration of transportation time during scheduling makes it more practical and useful. The purpose of this paper is to investigate multi-objective flexible job-shop scheduling problem (MOFJSP) considering transportation time.

Design/methodology/approach
A hybrid genetic algorithm (GA) approach is integrated with simulated annealing to solve the MOFJSP considering transportation time, and an external elitism memory library is employed as a knowledge library to direct GA search into the region of better performance.

Findings
The performance of the proposed algorithm is tested on different MOFJSP taken from literature. Experimental results show that proposed algorithm performs better than the original GA in terms of quality of solution and distribution of the solution, especially when the number of jobs and the flexibility of the machine increase.

Originality/value
Most of existing studies have not considered the transportation time during scheduling of jobs. The transportation time is significantly desired to be included in the FJSP when the time of transportation of jobs has significant impact on the completion time of jobs. Meanwhile, GA is one of primary algorithms extensively used to address MOFJSP in literature. However, to solve the MOFJSP, the original GA has a possibility to get a premature convergence and it has a slow convergence speed. To overcome these problems, a new hybrid GA is developed in this paper.
The effect of audit quality on the pension risk – cost of equity relation
Authors: Houmes Robert , Wang Daphne , Ngo Thanh 
Published: May 2019

Purpose
The purpose of this paper is to empirically investigate how audit quality affects the cost of equity (COE) defined benefit pension risk relation. As an antecedent to these tests, this study first uses implied COE measures and their pension intensity risk predictors to examine the relation between a defined benefit plan (DBP) firm’s implied COE and pension intensity risk. Then, using these measures, the authors provide new evidence on how audit quality affects this relation.

Design/methodology/approach
Using panel data over fiscal years 1999–2014, fixed effects models regress dependent variable, implied the COE on controls and proxies that measure pension intensity risk and pension intensity risk conditional on the quality of the audit.

Findings
This study documents that audit quality attenuates the positive relation between a sponsoring firm’s COE and pension risk. The authors rationalize these findings by asserting that the positive relation between a sponsoring firm’s COE and pension intensity risk reflects increased financial risk associated with higher pension obligations but the quality of the auditor attenuates this risk. This paper further documents that these findings are robust to a sponsoring firms’ level of financial distress.

Research limitations/implications
A limitation of this research is that the sample is limited to DBPs companies only. Although results of the tests show similar results for controls that are used in other COE-related studies that include DBP and non-DBP firms, the generalizability of the findings may be limited to the extent that the financial characteristics of firms without defined contribution plans differ from the sample.

Practical implications
Results of this study suggest that while pension intensity risk has COE implications, managers may be able to mitigate these effects by managing their plans and utilizing high-quality auditors.

Originality/value
Using implied COE and pension intensity risk measures, this study provides new information on the favorable effect that high-quality audits have on the COE – pension risk relation.
Using SERVQUAL to determine Generation Y’s satisfaction towards hoteling industry in Malaysia
Authors: Shafiq Ali , Mostafiz Md Imtiaz , Taniguchi Mutsumi 
Published: May 2019

Purpose
The purpose of this paper is to use SERVQUAL to measure Generation Y’s (Gen Y) perceived service quality and its effects on their satisfaction toward the Malaysian hotel industry.

Design/methodology/approach
The required data were collected through questionnaire, distributed to 200 respondents in four areas of Klang Valley. The collected data were put through multiple regression to identify the effect of SERVQUAL dimensions on service quality.

Findings
The results reveal that all the elements of SERVQUAL, except tangibility, had a significant and positive relationship with customer satisfaction.

Research limitations/implications
It is a niche area research which is done on a small population in a specified geographical area within Malaysia, though its research implications are significant and add significantly to the tourism literature with respect to Gen Y.

Practical implications
This research holds importance in the growing service tourism and hoteling industry in Malaysia, where Gen Y holds a key economic position and is predicted to grow even further in the near future.

Originality/value
It is a niche area research done on very specific consumers in Malaysia. It, therefore, adds to the emerging field of tourism in relation to Gen Y.
Re-evaluating supply chain integration and firm performance: linking operations strategy to supply chain strategy
Authors: Wiengarten Frank , Li Huashan , Singh Prakash J. , Fynes Brian 
Published: May 2019

PurposeThis paper aims to explore the performance implications of supply chain integration (SCI) taking a strategic perspective. Thus, this paper is set to provide answers to the following research questions: Does a higher degree of SCI always lead to greater firm performance improvements? As the answer to this question is likely to be no, the authors explore the performance implications from a strategic perspective: Is the SCI–performance relationship contingent on a company’s competitive priorities (i.e. operations strategy)?Design/methodology/approachThe authors explore their questions through multiple quasi-independent data sets to test the impact of SCI on firm performance. Furthermore, the authors provide a more nuanced conceptual and empirical view to explore the previously uncovered contradictory results and contingent relationship challenging the “more integration equals higher firm performance” proposition.FindingsThe results only provide partial support for the proposition that more integration is always beneficial in the supply chain context. The authors also identified that the impact of SCI on financial performance is contingent on a company’s competitive priorities.Originality/valueThis study provides a much-needed comprehensive assessment of the SCI–performance relationship through critically re-evaluating one of the most popular propositions in the field of supply chain management. The results can be extrapolated beyond the dyad, as the authors conceptualise integration simultaneously from an upstream and downstream perspective.
Long‐term efficacy and safety of bexarotene for Japanese patients with cutaneous T‐cell lymphoma: The results of a phase 2 study (B‐1201)
Authors: Hamada Toshihisa , Tokura Yoshiki , Sugaya Makoto , Ohtsuka Mikio , Tsuboi Ryoji , Nagatani Tetsuo , Kiyohara Eiji , Tani Mamori , Setoyama Mitsuru , Matsushita Shigeto , Kawai Kazuhiro , Yonekura Kentaro , Saida Toshiaki , Iwatsuki Keiji 
Published: May 2019

AbstractThe present study (B‐1201 clinical trial) was conducted as a multicenter, open‐label, single‐arm phase II study to evaluate the long‐term safety, tolerability and efficacy of bexarotene. This study enrolled 10 Japanese adults aged more than 20 years with cutaneous T‐cell lymphoma (CTCL) who completed the 24‐week study period of the B‐1101 trial. The objective response rate (ORR) was 53.8% (95% confidence interval, 25.1–80.8). In the early stage (IB), the ORR was 60% (3/5 cases). In the advanced stage (IIB and IIIA), the ORR was 57.1% (4/7 cases). The median time to response was 58 days (range, 27–168). The median treatment duration was 380 days (range, 33–1674). The median duration of response (DOR) could not be reached during the study period. The longest DOR reached 1618 days at the end of the B‐1201 trial. Nine patients (56.3%) in the full analysis set (FAS) population experienced dose reduction of bexarotene. Common drug‐related adverse events in the FAS population included hypothyroidism (93.8%), hypertriglyceridemia (81.3%), hypercholesterolemia (81.3%), leukopenia (68.8%) and neutropenia (56.3%). Dose‐limiting toxicity (DLT) was present in five (38.5%) of the 13 patients in the 300 mg/m2 cohort. Of the five patients, four developed grade 3 neutropenia and one developed grade 4 hypertriglyceridemia. All DLT cases recovered after the discontinuation of bexarotene. None of the five patients discontinued this trial because of DLT. The B‐1201 trial shows the long‐term safety of oral bexarotene for Japanese patients with CTCL, despite frequent dose reduction.
Resveratrol alleviates nuclear factor‐κB‐mediated neuroinflammation in vasculitic peripheral neuropathy induced by ischaemia–reperfusion via suppressing endoplasmic reticulum stress
Authors: Pan Po‐Ting , Lin Han‐Yu , Chuang Ching‐Wei , Wang Po‑Kai , Wan Hung‐Chieh , Lee Ming‐Cheng , Kao Ming‐Chang 
Published: May 2019

AbstractVasculitic peripheral neuropathy (VPN) arises from an inflammatory obstruction in the blood vessels supplying peripheral nerves and subsequent ischaemic insults, which exhibits the clinical features of neuropathic pain and impaired peripheral nerve function. VPN induced by ischaemia–reperfusion (IR) has been reported to involve nuclear factor‐κB (NF‐κB)‐mediated neuroinflammation. Recent studies have suggested that endoplasmic reticulum (ER) stress has been implicated in the development of peripheral neuropathies. Resveratrol possesses a potent anti‐inflammatory capacity. We hypothesized that resveratrol may exert a protective effect against VPN through modulating the interrelated ER stress and NF‐κB pathways. Male Sprague‐Dawley rats were allocated into five groups: sham, sham + resveratrol 40 mg/kg (R40), IR, IR + R20 and IR + R40. VPN was induced by occluding the right femoral artery for 4 hours followed by reperfusion. Our data have shown that VPN induced by IR led to hind paw mechanical allodynia, heat hyperalgaesia, and impaired motor nerve conduction velocity (MNCV). With resveratrol intervention, the behavioural parameters were improved in a dose‐dependent manner and the MNCV levels were increased as well. The molecular data revealed that VPN induced by IR significantly increased the expression of NF‐κB as well as the ER stress sensor proteins, protein kinase RNA‐like endoplasmic reticulum kinase, inositol‐requiring enzyme 1 and activating transcription factor 6 in the sciatic nerves. More importantly, resveratrol significantly attenuated the expression of NF‐κB and the ER stress sensor proteins after IR. In conclusion, resveratrol alleviates VPN induced by IR. The mechanisms may involve modulating NF‐κB‐mediated neuroinflammation via suppressing ER stress.
In silicoprediction of the secretome from the invasive neurotoxic marine dinoflagellateAlexandrium catenella
Authors: Chetouhi Cherif , Laabir Mohammed , Masseret Estelle , Jean Natacha 
Published: May 2019

SummaryAlexandrium catenella, a marine dinoflagellate responsible for harmful algal blooms (HABs), proliferates with greater frequency, distribution and intensity, in disturbed marine coastal ecosystems. The proteins secreted into seawater may play a crucial role in maintaining this dinoflagellate in these ecosystems, but this possibility has never been investigated before. In this study, theA. catenellasecretome was predicted from its transcriptome by combining several bioinformatics tools. Our results predict a secretome of 2 779 proteins, among which 79% contain less than 500 amino acids, suggesting that most secreted proteins are short in length. The predicted secretome includes 963 proteins (35%) with Pfam domains: 773 proteins with one Pfam domain and 190 proteins with two or more Pfam domains. Their functional annotation showed that they are mainly involved in (i) proteolysis, (ii) stress responses and (iii) primary metabolism. In addition, 47% of the secreted proteins appear to be enzymes, primarily peptidases, known to be biologically active in the extracellular medium during stress responses. Finally, this study provides a wealth of candidates of proteins secreted byA. catenella, which may interact with the marine environment and help this dinoflagellate develop in various environmental conditions.
MS‐275 potentiates the effect of YM‐155 in lung adenocarcinoma via survivin downregulation induced by miR‐138 and miR‐195
Authors: Luo Bai‐Ling , Zhou Yan , Lv Hui , Sun Sheng‐Hua , Tang Wen‐Xiang 
Published: May 2019

BackgroundYM‐155 has been proven to be an efficient antitumor suppressor in non‐small cell lung cancer (NSCLC) cells. However, the suppressive effect of YM‐155 on the expression of survivin is not sufficient and has a short half‐life. MS‐275, a histone deacetylase inhibitor, has significant antitumor capacity with a relatively long half‐life. Our study explored whether MS‐275 could enhance the inhibitory effect of YM‐155 on LUAD proliferation.MethodsTo investigate the synergistic effect of MS‐275 and YM‐155, we employed methyl thiazolyl tetrazolium and colony formation assays to access the inhibition effect of MS‐275, YM‐155, or a combination in A549 and HCC827 cell lines. We then detected the effect of MS‐275 and YM‐155 on the expression of survivin and pro‐apoptotic proteins by Western blot and miR‐138 or miR‐195 expression by quantitative PCR. We also analyzed the methylation level of microRNAs (miRNAs) using methylation‐sensitive quantitative PCR. Finally, we investigated the interaction between miRNAs and survivin by luciferase reporter assay.ResultsMS‐275 facilitated an inhibitory effect of YM‐155 on lung adenocarcinoma cell proliferation. MS‐275 can upregulate the level of acetylated H3, promote the degradation of DNA methyltransferases, and inhibit the methylation of miR‐138 and miR‐195 genes to elevate the expression of miR‐138 and miR‐195. Moreover, miR‐138 and miR‐195 showed a synergistic effect with YM‐155 by directly binding to the 3 untranslated region of survivin to attenuate its expression.ConclusionFor the first time, we report the synergistic effective of MS‐275 and YM‐155 and suggest a new direction for the future application of YM‐155.