bluuebunny/crossref_metadata_2025_split huggingface dataset:
Moisture adsorption isotherms and quality of seeds stored in conventional packaging materials and hermetic Super Bag
Authors: Bakhtavar Muhammad Amir , Afzal Irfan , Ahmed Basra Shahzad Maqsood 
Published: November 2018

AbstractSeed moisture content (SMC) is an important attribute to seed quality. Maintaining seed dryness throughout supply chain (The Dry Chain) prevents seed germination and quality losses. Ambient relative humidity (RH) and temperature affect seed moisture and thereof seed moisture isotherm. Present study was conducted to compare the moisture adsorption isotherms of wheat, maize, cotton and quinoa seeds packed in hermetic Super Bag and traditional packaging materials including paper, polypropylene (PP), jute and cloth bags. Seeds were incubated at 60, 70, 80 and 90% static RH. Nearly straight line moisture isotherms for all crop seeds were obtained in Super Bag. Seed moisture contents increased in traditional packaging materials with increasing RH. At higher level of RH, moisture contents increased slightly (1-2%) in Super Bag, whereas this increase was much higher in traditional packaging materials (≈9% higher than original SMC at 90% RH). In second study, seeds were dried to 8 and 14% initial seed moisture contents using zeolite drying beads and were stored in hermetic and traditional bags for a period of 18 months. For all crop seeds, germination was severely affected in all packaging materials both at 8 and 14% initial SMC except storage in Super Bag at 8% SMC. Wheat seed stored in Super Bag at 8% SMC almost maintained initial germination while germination of cotton, maize and quinoa seeds declined 7%, 14% and 30% respectively in Super Bag at 8% SMC. Seed storage in Super Bag can help to prevent the significant increase in seed moisture at higher RH as is evident from moisture isotherm study, thus helps to preserve quality of maize, wheat, cotton and quinoa seeds by maintaining The Dry Chain throughout the storage period.
Role of the Fourth Transmembrane Segment in TRAAK Channel Mechanosensitivity
Authors: Zhang Mingfeng , Yao Fuqiang , Pan Chengfang , Yan Zhiqiang 
Published: November 2018

AbstractMechanosensitive ion channels such as Piezo, TRAAK, TRPs and OSCA are important transmembrane proteins that are involved in many physiological processes such as touch, hearing and blood pressure regulation. Unlike ligand-gated channels or voltage-gated ion channels, which have a canonical ligand-binding domain or voltage-sensing domain, the mechanosensitive domain and related gating mechanism remain elusive. TRAAK channels are mechanosensitive channels that convert a physical mechanical force into a flow of potassium ions. The structures of TRAAK channels have been solved, however, the functional roles of the structural domains associated with channel mechanosensitivity remains unclear. Here, we generated a series of chimeric mutations between TRAAK and a non-mechanosensitive silent TWIK-1 K2P channel. We found that the selectivity filter region functions as the major gate of outward rectification and found that lower part of fourth transmembrane domain (M4) is necessary for TRAAK channel mechanosensitivity. We further demonstrated that upper part of M4 can modulate the mechanosensitivity of TRAAK channel. Furthermore, we found that hydrophilic substitutions of W262 and F121 facing each other, and hydrophobic substitutions of Q258 and G124, which are above and below W262 and F121, respectively, greatly increase mechanosensitivity, which suggests that dynamic interactions in the upper part of M4 and PH1 domain are involved in TRAAK channel mechanosensitivity. Interestingly, these gain-of-function mutations are sensitive to cell-poking stimuli, indicating that cell-poking stimuli generate a low membrane mechanical force that opens TRAAK channels. Our results thus showed that fourth transmembrane domain of TRAAK is critical for the gating of TRAAK by mechanical force and suggested that multiple dynamic interactions in the upper part of M4 and PH1 domain are involved in this process.
Task-Related Hemodynamic Responses Are Modulated by Reward and Task-engagement
Authors: Cardoso Mariana M. B. , Lima Bruss , Sirotin Yevgeniy B. , Das Aniruddha 
Published: November 2018

AbstractHemodynamic recordings from visual cortex contain powerful endogenous task-related responses that may reflect task-engagement distinct from attention. We tested this hypothesis with hemodynamic measurements (intrinsic-signal optical imaging) from monkey V1, while the animals’ engagement in a periodic fixation task over several hours was varied though reward size, and as animals took breaks. With higher rewards, animals appeared more task-engaged; task-related responses were more temporally precise at the task period (~ 10-20 seconds), and modestly stronger. Surprisingly, 2-5-minute blocks of high-reward trials led to ramp-like decreases in mean local blood volume; these reversed with ramp-like increases during low reward. The blood volume increased even more sharply when the animal shut his eyes and disengaged completely from the task (5-10 minutes). We propose a mechanism that controls vascular tone, likely along with local neural responses, with phasic and tonic components tied to task-engagement.
Dual metabolomic profiling uncovers Toxoplasma manipulation of the host metabolome and the discovery of a novel parasite metabolic capability
Authors: Olson William J. , Stevenson David , Amador-Noguez Daniel , Knoll Laura J. 
Published: November 2018

AbstractThe obligate intracellular parasite Toxoplasma gondii is auxotrophic for several key metabolites and must scavenge these from the host. It is unclear how Toxoplasma manipulates host metabolism for its overall growth rate and non-essential metabolites. To address this question, we measured changes in the joint host-parasite metabolome over a time course of infection. Host and parasite transcriptomes were simultaneously generated to determine potential changes in metabolic enzyme levels. Toxoplasma infection increased activity in multiple metabolic pathways, including the tricarboxylic acid cycle, the pentose phosphate pathway, glycolysis, amino acid synthesis, and nucleotide metabolism. Our analysis indicated that changes in some pathways, such as the tricarboxylic acid cycle, derive from the parasite, while changes in others, like the pentose phosphate pathway, were host and parasite driven. Further experiments led to the discovery of a Toxoplasma enzyme, sedoheptulose bisphosphatase, which funnels carbon from glycolysis into ribose synthesis through a energetically driven dephosphorylation reaction. This second route for ribose synthesis resolves a conflict between the Toxoplasma tricarboxylic acid cycle and pentose phosphate pathway, which are both NADP+ dependent. During periods of high energetic and ribose need, the competition for NADP+ could result in lethal redox imbalances. Sedoheptulose bisphosphatase represents a novel step in Toxoplasma central carbon metabolism that allows Toxoplasma to satisfy its ribose demand without using NADP+. Sedoheptulose bisphosphatase is not present in humans, highlighting its potential as a drug target.Author SummaryThe obligate intracellular parasite Toxoplasma is commonly found among human populations worldwide and poses severe health risks to fetuses and individuals with AIDS. While some treatments are available they are limited in scope. A possible target for new therapies is Toxoplasma’s limited metabolism, which makes it heavily reliant in its host. In this study, we generated a joint host/parasite metabolome to better understand host manipulation by the parasite and to discover unique aspects of Toxoplasma metabolism that could serve as the next generation of drug targets. Metabolomic analysis of Toxoplasma during an infection time course found broad activation of host metabolism by the parasite in both energetic and biosynthetic pathways. We discovered a new Toxoplasma enzyme, sedoheptulose bisphosphatase, which redirects carbon from glycolysis into ribose synthesis. Humans lack sedoheptulose bisphosphatase, making it a potential drug target. The wholesale remodeling of host metabolism for optimal parasite growth is also of interest, although the mechanisms behind this host manipulation must be further studied before therapeutic targets can be identified.
Subthalamic nucleus and sensorimotor cortex activity during speech production
Authors: Chrabaszcz A , Neumann WJ , Stretcu O , Lipski WJ , Bush A , Dastolfo-Hromack C , Wang D , Crammond DJ , Shaiman S , Dickey MW , Holt LL , Turner RS , Fiez JA , Richardson RM 
Published: November 2018

ABSTRACTThe sensorimotor cortex is somatotopically organized to represent the vocal tract articulators, such as lips, tongue, larynx, and jaw. How speech and articulatory features are encoded at the subcortical level, however, remains largely unknown. We analyzed local field potential (LFP) recordings from the subthalamic nucleus (STN) and simultaneous electrocorticography recordings from the sensorimotor cortex of 11 patients (1 female) with Parkinson’s disease during implantation of deep brain stimulation (DBS) electrodes, while patients read aloud three-phoneme words. The initial phonemes involved either articulation primarily with the tongue (coronal consonants) or the lips (labial consonants). We observed significant increases in high gamma (60–150 Hz) power in both the STN and the sensorimotor cortex that began before speech onset and persisted for the duration of speech articulation. As expected from previous reports, in the sensorimotor cortex, the primary articulator involved in the production of the initial consonant was topographically represented by high gamma activity. We found that STN high gamma activity also demonstrated specificity for the primary articulator, although no clear topography was observed. In general, subthalamic high gamma activity varied along the ventral-dorsal trajectory of the electrodes, with greater high gamma power recorded in the more dorsal locations of the STN. These results demonstrate that articulator-specific speech information is contained within high gamma activity of the STN, with similar temporal but less specific topographical organization, compared to similar information encoded in the sensorimotor cortex.SIGNIFICANCE STATEMENTClinical and electrophysiological evidence suggests that the subthalamic nucleus is involved in speech, however, this important basal ganglia node is ignored in current models of speech production. We previously showed that subthalamic nucleus neurons differentially encode early and late aspects of speech production, but no previous studies have examined subthalamic functional organization for speech articulators. Using simultaneous local field potential recordings from the sensorimotor cortex and the subthalamic nucleus in patients with Parkinson’s disease undergoing deep brain stimulation surgery, we discovered that subthalamic nucleus high gamma activity tracks speech production at the level of vocal tract articulators, with high gamma power beginning to increase prior to the onset of vocalization, similar to cortical articulatory encoding.
Interpretive multi-criteria valuation of flexibility initiatives on direct value chain
Authors: Sushil Sushil 
Published: November 2018

Purpose
Activities on direct value chain directly add value to the products/services delivered to the customers. This value addition can be further enhanced by taking up flexibility initiatives on these direct value chain activities. The purpose of this paper is to identify flexibility initiatives on the direct value chain and carry out their valuation.

Design/methodology/approach
Since different value addition criteria (i.e. benefits and costs) may be both tangible and intangible, an interpretive valuation based on multi-criteria framework would be desirable. The paper deploys the efficient interpretive ranking process (IRP) for this purpose. It uses total interpretive structural modeling (TISM) to derive weights of criteria based on their respective driving power. The paper also makes a methodological contribution to assess transitive dominance in IRP based on transitivity check as used in the modified TISM process.

Findings
The paper uses a multi-criteria valuation to examine the proposition that the flexibility initiatives will add a higher value as we go downstream in the value chain. The flexibility initiatives linked with marketing such as product upgradation and switching, customized services and dynamic pricing are found to be most value adding in character.

Research limitations/implications
The main limitation of this study is that it is generic in nature and need to be replicated in multiple case situations. The methodology proposed can be utilized for specific case analysis for flexibility valuation on the direct value chain.

Practical implications
The practitioners may be able to use the proposed method of TISM–IRP with improvements in real-life applications. The proposed multi-criteria valuation is interpretive in nature and can be utilized by practicing managers in group settings even if they do not have complete data.

Originality/value
The strategy and operations researchers will find promise in the methodology to investigate and prioritize the initiatives planned to enhance flexibility in different value chain activities. The researchers on multi-criteria decision making will find the methodological enhancement proposed in terms of graphically deriving the transitive dominance to be useful in other applications as well.
Case study analysis of e-waste management systems in Germany, Switzerland, Japan and India
Authors: Chaudhary Karishma , Vrat Prem 
Published: November 2018

Purpose
The purpose of this paper is to analyze e-waste management systems in Germany, Switzerland, Japan and India and benchmark best practices in the Indian scenario.

Design/methodology/approach
The first part of the research paper focuses on the description of e-waste management systems in the above-mentioned countries using a case study analysis approach while the second part analyzes, evaluates and compares e-waste management systems performance based on seven performance indicators using a five-point scale. Finally, the RADAR chart approach is used to benchmark the best practices of e-waste management in these countries in the Indian scenario.

Findings
The study finds that India is lagging far behind from Germany, Switzerland, and Japan in e-waste management despite being the fifth largest e-waste generator across the globe. India must adopt best practices followed in these nations like a dedicated agency to oversee and coordinate the e-waste management, coordination among different value chain partners involved in e-waste management, development of infrastructure to collect and process e-waste, monitoring and control of all processes and stakeholders, etc.

Practical implications
The study suggests the solution to the loopholes in the Indian e-waste management system by adopting the collection, recycling and reporting mechanism followed in German, Swiss and the Japanese e-waste management system. There is a dire need to improve e-waste management systems in India as only 5 percent of e-waste is processed through the organized sector.

Social implications
E-waste is increasing at an alarming rate and most of e-waste in India is being handled by the unorganized sector, where rudimentary methods are used to process e-waste severely damaging the environment and health of workers. The unorganized market employs 0.5m child laborers. Hence, routing the e-waste to the organized sector will result in social benefits by putting a check on unsafe practices and will create green jobs.

Originality/value
This paper’s contribution lies in extracting the best practices followed in nations excelling in e-waste management and recommend their implications in the Indian scenario. This study is aimed at all the stakeholders, but especially at policy-makers and producers, who have the onus to tackle the e-waste problem.
Experiential learning: analyzing success and failures in Indian telecom sector
Authors: Singh Shaili , Guha Mahua 
Published: November 2018

PurposeThe purpose of this paper is to study the self and vicarious learning patterns of organizations through operational success and benchmark failure experiences. The study is specific to the Indian telecom sector.Design/methodology/approachThis study uses published data of four major telecom firms in India reported by Telecom Regulatory Authority of India (TRAI) and analyzed the influence of aspiration performance discrepancy on organizational learning by hypotheses testing. Feasible generalized least square model with year fixed effects is used to run panel data regression.FindingsIn the case of operating experience for performance above aspiration, firms fail to learn from their own experience as well as from others’ experiences. For benchmark failure experience under positive discrepancy, firms learn from their own experience. For performance below aspiration, no significant result was found. These insights allow managers to reconfigure their learning orientation and to develop an effective mechanism for absorbing crucial knowledge from themselves and peer firms.Practical implicationsPractitioners should take into account that their knowledge repertoire is essential for learning in good times. This study also motivates managers involved in operating activities to make use of publicly disclosed reports, engage in vicarious learning or form a coalition for developing coping mechanism under negative discrepancy scenarios.Originality/valueThis paper presents a unique context by studying operational success, and failure experiences of telecom sector in India wherein benchmark for failure was decided by the governing regulatory body, TRAI, unlike other studies where success and failures reference points are intrinsically selected.
Sustainability orientation, supply chain integration, and SMEs performance: a causal analysis
Authors: Shashi Shashi , Cerchione Roberto , Centobelli Piera , Shabani Amir 
Published: November 2018

PurposeThe pressure of globalization has raised social concerns related to the protection of the environment, forced companies to use sustainability as a strategic weapon to fulfill the legal obligations and achieve overall competitiveness. It is reported that small- and medium-sized enterprises (SMEs) are globally responsible for approximately 70 percent of the industrial pollution, justifying urgent attention to the operations of these businesses. The purpose of this paper is to analyze the impact of sustainability orientation (SO) and supply chain (SC) integration implemented by SMEs on their sustainable procurement (SP) and design. Moreover, this study examines how SMEs’ SP and design affect their environmental and cost performance (CP).Design/methodology/approachThe authors develop a comprehensive model to test the relationships among SC, SC integration, SP, sustainable design (SD), environmental performance (EP) and CP at the SMEs level. The authors investigate the relationships of the mentoned factors by a data set that is collected from 358 Indian manufacturing SMEs.FindingsThe results indicate that in the SMEs’ context: SO positively influences both SP and SD; external integration positively affects SP; internal integration positively affects SD; SP positively influences EP and has not impact on CP; and SD positively influences both EP and CP.Originality/valueThis study provides a broad view of the relation between driving factors that may direct SMEs toward a better sustainability performance and offers practical managerial insights into these important business entities.
Authentic leadership, career self-efficacy and career success: a cross-sectional study
Authors: Chughtai Aamir 
Published: November 2018

PurposeThe purpose of this paper is to explore the effects of authentic leadership on employees’ objective (hierarchical status) and subjective (career satisfaction) career success. In addition, this paper attempts to examine the mediating role of career self-efficacy in these relationships.Design/methodology/approachThe sample for this cross-sectional study comprised of 162 Pakistani employees drawn from a leading food and beverage company. Structural equation modelling and the bootstrapping procedure were used to test the research hypotheses.FindingsResults showed that career self-efficacy fully mediated the relationship between authentic leadership and hierarchical status, while it partially mediated the effects of authentic leadership on career satisfaction.Practical implicationsThe findings of this study indicate that authentic leadership behaviours can have a positive impact on employees’ career success. Thus, in order to ensure that employees accomplish their career goals and realise their full potential, it is vital that organisations devise strategies, which are geared towards promoting authentic leadership.Originality/valueThis paper provides a first examination of the relationship between authentic leadership and two indicators of career success: hierarchical status and career satisfaction. In addition, it identifies one possible pathway in the form of career self-efficacy through which authentic leadership relates to employees’ career success.
Top managers and the gendered interplay of organizations and family life: the case of Iceland
Authors: Júlíusdóttir Ólöf , Rafnsdóttir Guðbjörg Linda , Einarsdóttir Þorgerður 
Published: November 2018

PurposeIceland, along with the other Nordic countries, is seen as an international frontrunner in gender equality and equal sharing of responsibility for paid and unpaid work is part of the official ideology. Nevertheless, the number of women in leadership positions remains low. The purpose of this study is to analyse the practices that (re)produce power imbalances between women and men in business leadership both at the macro and the micro levels. This is done by using two theoretical explanations: gendered organizational practices and the interplay of organizations and family life.Design/methodology/approachThe mixed methods are applied by analysing 51, semi-structured interviews with female and male business leaders and survey data from CEOs and executives from the 250 largest companies in Iceland.FindingsThe analyses reveal gender differences and asymmetries in work life as well as within the family. Men have longer working hours than women, higher salaries and more job-related travelling. Women carry the dual burden of work and family to a higher degree than do men. By questioning and attempting to resist the organizational culture women risk further disadvantage. The situation of male and female leaders is therefore incomparable. This is a paradox and does not fit with the idea of the Nordic gender equality of a dual breadwinner society.Originality/valueIt is shown that lack of gender diversity in business leadership is based on gendered organizational practices as well as on power relations within families. These two aspects are mutually reinforcing and the originality of the study is to explore the interplay between them. The authors conclude that despite being the country at the forefront of gender equality in the world, neither organizational practices nor family relations recognize the different life experiences of women and men in Iceland. This is expressed in organizational practices and different access to time and support, which may hinder gaining gender equality in top leadership.