bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interfacial actin protrusions mechanically potentiate killing by cytotoxic T cells
Authors: Tamzalit Fella , Wang Mitchell S. , Jin Weiyang , Boyko Vitaly , Heddleston John M. , Black Charles T. , Kam Lance C. , Huse Morgan 
Published: October 2018

ABSTRACTCytotoxic T lymphocytes (CTLs) kill by forming immunological synapses with target cells and secreting toxic proteases and the pore forming protein perforin into the intercellular space. Immunological synapses are highly dynamic structures that potentiate perforin activity by applying mechanical force against the target cell. Here, we employed high-resolution imaging and microfabrication to investigate how CTLs exert synaptic forces and coordinate their mechanical output with perforin secretion. Using micropatterned stimulatory substrates that enable synapse growth in three dimensions, we found that perforin release occurs at the base of actin-rich protrusions that extend from central and intermediate locations within the synapse. These protrusions, which depended on the cytoskeletal regulator WASP and the Arp2/3 actin nucleation complex, were required for synaptic force exertion and efficient killing. They also mediated physical distortion of the target cell surface during CTL-target cell interactions. Our results reveal the mechanical basis of cellular cytotoxicity and highlight the functional importance of dynamic, three-dimensional architecture in immune cell-cell interfaces.One sentence summaryCytotoxic T lymphocytes use F-actin-rich protrusions at the immunological synapse to potentiate perforin-and granzyme-mediated target cell killing.
Sclerosing nevus with pseudomelanomatous features: dermoscopic and confocal aspects
Authors: Bombonato C. , Pampena R. , Franceschini C. , Piana S. , Perino F. , Di Stefani A. , Ardigò M. , Fargnoli M.C. , Frascione P. , Borsari S. , Pellacani G. , Peris K. , Longo C. 
Published: October 2018

AbstractBackgroundSclerosing nevus with pseudomelanomatous features (SNPFs) is a clinical and pathologic entity that mimics melanoma both clinically and histologically.The lesion is a melanocytic nevus, histologically characterized by fibrosis and a pseudomelanomatous proliferation. It is typically seen in young to middle‐aged individuals, mainly on the back, where microtrauma or inflammatory changes are more frequent. Dermoscopic description of SNPF has been reported so far in one case series.ObjectiveThe aim of our study was to describe the dermoscopic and confocal features of SNPF.MethodsHistopathologically confirmed cases of SNPF were retrospectively collected from three referral centres in Italy. Only lesions with available clinical, dermoscopic and histopathological data were included; confocal images were also retrieved, when available. Lesions were evaluated for the presence of 12 dermoscopic and five confocal criteria previously described.ResultsThe study population included 93 lesions in as many patients (71 men and 22 women; median age: 38 years). Dermoscopically, we found a predominance of dark colours, in particular brown and blue, which were found in all lesions and the vast majority of the lesions (86/93; 92.5%) displayed at least one structureless area. By the combination of colours and structures, we observed that the majority of the lesions (67/92; 72%) were characterized by more than one structure and more than one colour.Confocal evaluation was performed on a subset of 24/93 lesions showing a regular architecture pattern (19/24 cases, 79%), with a predominance of the ringed pattern. The presence of focal cytologic atypia at the dermal‐epidermal junction was present in 12/24 cases (50%) with a prevalent dendritic‐shaped cell proliferation.ConclusionsThe current study demonstrated that SNPF was frequently characterized, on dermoscopic examination, by more than one structure and more than one colour and on confocal microscopy by a regular ringed pattern with focal dendritic atypical cells.
Evaluation of the agreement between TNM 7th and 8th in a population‐based series of cutaneous melanoma
Authors: Crocetti E. , Stanganelli I. , Mancini S. , Vattiato R. , Giuliani O. , Ravaioli A. , Balducci C. , Falcini F. , Pimpinelli N. 
Published: October 2018

AbstractBackgroundThe 8th edition of TNM has introduced new rules for staging cutaneous melanoma.ObjectiveTo compare TNM 7th and 8th editions in defining pathological stages of melanoma.MethodsA population‐based series of 1847 skin melanoma from Romagna cancer registry (Italy) incident during 2003–2012 has been used to measure the agreement (with Cohen's kappa) between TNM 8th and 7th editions in defining melanoma stage. Disease‐specific survival has been computed for each stage according to TNM 7th and 8th.ResultsThe agreement between the two TNM editions was quite good when considered on average (kappa = 70.7%), moderate for stage I (61.5%), nearly perfect for stage II (95.0%), but extremely poor for stage III (8.1%). The overall melanoma‐specific observed survival was 90.8% at 5 year and 88.9% at 10 year with a strong prognostic effect of stage.ConclusionTNM 8th edition introduces several changes which do not seem really helpful in addressing the care of stage I melanoma and may complicate the definition and comparability of stage III.
Will they stay or will they go? Narcissistic admiration and rivalry predict ingroup affiliation and devaluation
Authors: Benson Alex J. , Jeschke Jessica , Jordan Christian H. , Bruner Mark W. , Arnocky Steven 
Published: October 2018

AbstractObjectiveUsing the narcissistic admiration and rivalry concept (NARC) as a guiding framework, the current research examines how ingroup affiliation and devaluation are connected to the self‐enhancing and self‐threatening properties of ingroups for narcissists.MethodParticipants (N = 374) completed a group decision‐making task and received feedback that factorially manipulated both individual and group performance. Across the four combinations of performance feedback, we examined the conditional effects of narcissistic admiration and rivalry on social identity, perceptions of group member ability, desire to abandon the group, and desire to expel group members.ResultsNarcissistic admiration predicted higher levels of social identity in response to ingroup success, regardless of individual performance. In contrast, narcissistic rivalry predicted more negative views of group ability, as well as a higher desire to abandon the group and expel group members in response to individual success combined with ingroup failure.ConclusionThe results document and provide insight into narcissists’ fickle attachment to ingroups. They provide evidence of the utility of the NARC in group contexts. Our findings suggest that narcissistic admiration is linked to self‐enhancing group affiliation, whereas narcissistic rivalry is related to self‐protective group distancing and devaluation.
Effects of hydration status during heat acclimation on plasma volume and performance
Authors: Pethick Wendy A. , Murray Holly J. , McFadyen Paula , Brodie Ryan , Gaul Catherine A. , Stellingwerff Trent 
Published: October 2018

The impact of hydration status was investigated during a 5‐day heat acclimation (HA) training protocol vs mild/cool control conditions on plasma volume (PV) and performance (20 km time‐trial [TT]). Sub‐elite athletes were allocated to one of two heat training groups (90 min/day): (a) dehydrated to ~2% body weight (BW) loss in heat (35°C; DEH; n = 14); (b) euhydrated heat (35°C; EUH; n = 10), where training was isothermally clamped to 38.5°C core temperature (Tc). A euhydrated mild control group (22°C; CON; n = 9) was later added, with training clamped to the same relative heart rate (~75% HRmax) as elicited during DEH and EUH; thus all groups experienced the same internal training stress (%HRmax). Five‐day total thermal load was 30% greater (P < 0.001) in DEH and EUH vs CON. There were significant differences in the average percentage of maximal work rate (%Wmax) across all groups (DEH: 24 ± 6%; EUH: 34 ± 9%; CON: 48 ± 8%Wmax) during training required to elicit the same %HRmax (77 ± 4% HRmax). There were no significant differences pre‐to post‐HA between groups for PV (DEH: +1.7 ± 10.1%; EUH: +4.8 ± 10.2%; CON: +5.2 ± 4.0%), but there was a significant pooled group PV increase, as well as a 97% likely pooled improvement in TT performance (DEH: −1.8 ± 2.8%; EUH: −1.9 ± 2.1%, CON; −1.8 ± 2.8%; P = 0.136). Due to a lack of between‐group differences for PV and TT, but pooled group increases in PV and 97% likely group increase in TT performance, over 5 days of intense training at the same average relative cardiac load suggests that overall training stress may also impact significant adaptations beyond heat and hydration stress.
BİLGİSAYAR MÜHENDİSLİĞİ ÖĞRENCİLERİNİN MESLEK SEÇİM KRİTERLERİNİN AHP İLE AĞIRLIKLANDIRILMASI VE SIRALANMASI
Authors: Kuvat Özlem 
Published: October 2018

Meslek seçimi öğrencilerin geleceklerinin şekillendirilmesinde
önemli kararlardan birisidir ve karar aşamasında olan bireylerin dikkate alması
gereken pek çok kriter bulunmaktadır. Bilgisayar Mühendisliği mesleği seçiminde
de öğrenciler pek çok genel kriteri dikkate almakla birlikte özel olarak mesleğin
ayırt edici özelliklerinin de değerlendirildiği kriterleri de göz önüne
almaktadırlar. Burada öğrencilerin hem
kendi kişilik özelliklerini hem de mesleğin taşıdığı bazı özellikleri
değerlendirmeleri gerekmektedir. Bu çalışmada 2016-2017 Eğitim Öğretim Yılı
Balıkesir Üniversitesi Bilgisayar Mühendisliği 1. Sınıf öğrencilerinin meslek
seçimleri kriterlerinin önem dereceleri ve bu kriterlerin sıraları
belirlenmiştir. Öğrencilerin doldurdukları formlara dayanarak veriler elde
edilmiştir. Meslek seçim kriterleri sübjektif yargıları da barındırdığından
Analitik Hiyerarşi Prosesi ile bu dereceleme ve sıralama işlemleri yapılmıştır.
Burada öğrencilerin almış oldukları bir kararda hangi kriterleri öncelikli
olarak değerlendirdiklerini belirlemek ve bu kriterlerin önem düzeylerini
ağırlıklandırmak amaçlanmıştır. Bu şekilde özellikle Bilgisayar Mühendisliği
için meslek tanıtımlarının yapılmasında ve öğrencilerin ihtiyaçlarının
belirlenmesinde bu kriterlerin etkisi daha fazla dikkate alınabilecektir.
PUTTING ‘N’ or REPLACING THE ‘S’ IN THE BRICS? NIGERIA’S RISE AS AN EMERGING POWER
Authors: HASHIRU Mohammed , TÜFEKÇİ Özgür 
Published: October 2018

The economic and political strides made by Nigeria and South Africa in the 21st Century have drawn the attention of the world to them. In order to accelerate its goal of enhancing market access opportunities among other objectives to ensure growth as well as compete with G7, the club incorporated the South African state in 2010 when it realized the nation is an emerging power and could be a catalyst in pushing forward the BRIC agenda. Since investors appear to be quite attracted to states with larger prospects of growth, states who are looking out for similar states with interests to form clubs like BRICS are likely to cooperate with Nigeria as it has been projected to be suitable in the formation of clubs such as MINT -Mexico, Indonesia, Nigeria, Turkey-. We argue however that both Nigeria and South could, if brought together in BRICS, facilitate progress in achieving the aims and objectives of the club. But what informed the clubs’ decision of incorporation of South Africa? This paper will the question and give more reasons why Nigeria’s inclusion is necessary
A multi-method case study of textile craft-design applications – usability and effects on the design process
Authors: Sini Riikonen , Pirita Seitamaa-Hakkarainen 
Published: October 2018

Abstract
This article presents a multi-method case study of five mobile device and desktop computer applications intended specifically for craft-design. The main aim of the study was to investigate the effects of application usage on the craft-design process and to analyse the usability of the applications from three perspectives: user experience, traditional usability and functionality. Eight master’s level craft teacher students evaluated the applications and used those to conduct a design task on a Virtual Design Studio course at the University of Helsinki. To enable an authentic working environment and style for the participants and to gather research data remotely, a multi-method approach was designed that included data from questionnaires, written tasks and recordings of screen events. Analysis of the effects of application usage on the craft-design process revealed three factors that promote changes: the usability of an application, new possibilities and limitations compared to traditional design methods and the technical expertise of the designer – usability being the most significant factor behind the changes observed.
Intersecting modes of aesthetic distance and mimetic induction in therapeutic process: Examining a drama-based treatment for military-related traumatic stress
Authors: Ali Alisha , Wolfert Stephan , Lam Ingrid , Rahman Tazmin 
Published: October 2018

Abstract
Can Shakespeare be a treatment for posttraumatic stress in military veterans? This is the question that our research team has been examining through the empirical investigation of the DE-CRUIT program. DE-CRUIT uses Shakespeare’s verse to help veterans with the articulation, sharing and processing of trauma. In this article, we focus specifically on the therapeutic process of the program that involves various modes of aesthetic distance in combination with mimetic induction, a treatment technique in which fictionalized narrative reflects the real-life experience of trauma. After describing that process, we illustrate these various intersecting therapeutic components through the case of ‘D.’, a military veteran who took part in DE-CRUIT after many years of living with a secret, non-disclosed trauma.
Drama therapy and the invisible realm
Authors: Pendzik Susana 
Published: October 2018

Abstract
This article is based on the Keynote for the 38th Annual Conference of the North American Drama Therapy Association, ‘From theory to practice: The drama therapist’s toolbox’, Danvers, Massachusetts, 2017. The speech explored the notion of the ‘invisible’ in drama therapy, in dialogue with four interrelated bodies of knowledge that partake of this concept: shamanism, theatre/arts, psychotherapy and spirituality. By focusing on the invisible, a genuine tool of drama therapy, within a comparative outlook, this article positions the field within a broader perspective while simultaneously pointing out its uniqueness.
A brief history of Japanese popular culture in Japanese language education: Using ‘manga’ in the classroom
Authors: Iida Sumiko , Takeyama Yuki 
Published: October 2018

Abstract
This article discusses a history of Japanese popular culture (JPC) located in the broader field of Japanese language education, particularly focusing on ‘manga’. JPC has drawn the public attention of Japanese language educators following an international boom in the consumption of anime and ‘manga’ in the early 2000s. However, looking into JPC and its location in the context of Japanese language education, its history goes further back to the late 1980s and the early 1990s, when ‘manga’ and anime began to be used in classrooms. Despite active attempts using JPC in Japanese language education, research into this field was still inactive until the end of the twentieth century. This article is therefore aimed at connecting classroom practices and research into JPC over time since the late 1980s to look into how JPC in Japanese language education has been viewed and used differently in its trajectory and implies its future direction. The article first critically discusses the early days of JPC, namely ‘manga’ in Japanese language education by reviewing three periodicals of the early to the mid-1990s – Mangajin, Gekkan Nihongo and Nihongo Kyōiku Tsūshin. Second, the article overviews research into ‘manga’/anime and Japanese language education from the late 1980s to early 2010. The results of the analyses imply that the early days of JPC in Japanese language education were triggered by the struggle of the instructors finding teaching resources rather than the motivation of the learners. In contrast, a number of more recent studies of JPC in Japanese language education align with both the learners’ and the teachers’ demands and motivations of daily classroom practice.
Curating as a dialogue-based strategy in art education
Authors: Vella Raphael 
Published: October 2018

Abstract
Contemporary artists are increasingly engaging in curatorial work and strategies while curators interpret the exhibition as an artistic medium in its own right. The teaching of art in schools and art education programmes in universities, however, does not often integrate curating as an activity or field of study within more conventional studio classes or methodologies for teaching and learning art. After briefly outlining a history of key artist-curators, this article suggests that curating – particularly its collaborative, social qualities – can enrich art pedagogies and curricula, and proposes four curatorial processes that could positively expand the remit of art education. These processes are understood as integral aspects of art-making and focus on the development of a pedagogy of dialogue, creating dialogues between different artworks and objects, dialogues between curatorial positions, dialogues between works of art and various publics, and finally, facilitating the etymological notion of ‘care’ within the art class.
The Title I narrative: Connecting cultural and critical awareness through the arts
Authors: Herring Aimee , Hunter-Doniger Tracey 
Published: October 2018

Abstract
This article discusses a case study that investigated preservice generalist teachers in a visual and performing arts methods class. It was revealed that three themes reoccurred throughout this course that centred on children of low socio-economic status. These themes included reaching the Title I students, connecting through cultural awareness and critical awareness through the arts. The significance and implications of these themes demonstrate there is a need for art education methods courses to explicitly address these issues and provide avenues for preservice generalists to enhance the learning of their future students.
A new tool for developmental assessment based on the Common European Framework of Reference for Visual Literacy – an international usability study
Authors: Groenendijk Talita , Haanstra Folkert , Kárpáti Andrea 
Published: October 2018

Abstract
What competences in visual literacy should students and European citizens in general master to be able to participate in contemporary society? This central question was addressed by the European Network of Visual Literacy (ENViL). This international community of experts developed a structure of sixteen subcompetences: the Common European Framework of Reference for Visual Literacy. Based on this framework, we developed a tool for self-assessment in secondary education: the visual rubrics. This tool was tested in several countries. The current article describes the evaluation of the criteria included in the tool and students’ comprehension of the tool as a self-assessment system. The consequences for improved rubrics are discussed.
Theses on Babylonian Philosophy
Authors: Van De Mieroop Marc 
Published: October 2018

Abstract
Through an enumeration of six theses this article argues that there was indeed a system of thought in ancient Babylonia that we can call philosophy, despite what the famous mid-twentieth century ad book Before Philosophy. The Intellectual Adventure of Ancient Man maintained. We can discover the principles of systematic thought in the numerous lists that Babylonians and other writers of cuneiform in the ancient Near East used. The key to philosophical understanding lay in the idea that writing produced a truth of its own, distinct from what was observable in physical reality.
Crystal structure of methyl 4-(3-phenoxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C26H27NO4
Authors: Gou Wei , Chen Gang , Chen Wei-Yong , Li Wen-Jun , Feng Jing 
Published: October 2018

Abstract
C26H27NO4, monoclinic, P21/c (no. 14), a = 12.034(4) Å, b = 15.247(5) Å, c = 12.991(4) Å, β = 115.379(6)°, V = 2153.6(12) Å3, Z = 4, R
gt(F) = 0.0531, wR
ref(F
2) = 0.1447, T = 296 K.
Crystal structure of 2-(4-chlorophenyl)-3-phenyl-1,8-naphthyridine, C20H13N2Cl
Authors: Li Yi-Biao , Chen Lu , Zhu Zhong-Zhi , Huang Yu-Bing , Chen Xiu-Wen 
Published: October 2018

Abstract
C20H13N2Cl, monoclinic, P21/n (no. 14), a = 6.179(4) Å, b = 11.666(8) Å, c = 22.460(15) Å, β = 95.837°, V = 1610.6(19) Å3, Z = 4, R
gt(F) = 0.0507, wR
ref(F
2) = 0.1599, T = 296(2) K.
The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase
Authors: Kocabaş Rahim , Aköz Mehmet 
Published: October 2018

Abstract

Objective
Conflicting data are available in literature regarding the effects of vitamin D (VitD) supplementation diet on lipid panel. Therefore, we had the purpose to evaluate the effects of VitD supplementation on lipid panel by a controlled experimental study, and those of VitD supplementation on oxidative stress index (OSI) and paraoxonase-1 (PON1) values in healthy and hypercholesterolemic male rabbits.

Methods
Thirty New Zealand rabbits were randomly separated into control, VD, HC+VD and HC groups. Control and VD groups were fed with standard chow, whereas HC+VD and HC groups were fed with 0.5% cholesterol chow a period of 8 weeks. During this period, VD and HC+VD groups were orally administered with 300 IU/kg/day VitD.

Results
The increase in serum total cholesterol (TC) and OSI level of HC group were significant compared to those in HC+VD group. Decreases in serum HDL-cholesterol (HDL-C) and TC levels of VD group were significant within the groups.

Conclusion
Without any doubt it is important that applied VitD level should be in the ideal range for healthy living. However, it is also necessary to increase the serum HDL-C level (and hence PON1), which is decreases as a result of VitD supplementation. Therefore, we believe that during VitD supplementation, regular physical activity should be performed to increases serum HDL-C.
Problems of Islamic Law Compilation In Indonesia
Authors: Purkon Arip 
Published: October 2018

Abstract.Islamic Law Compilation is one of the efforts to implement Islamic law in Indonesia constitutionally. Islamic Law Compilation covers three legal fields, namely marriage, inheritance and benefiction. The Islamic Law Compilation contributes positively in providing legal certainty, especially for judges in religious courts. In addition, there are still a number of problems related to the Islamic Law Compilation, namely the issue of socialization, equality of perception and the fear of reducing Islamic law.Keywords: Islamic Law Compilation, Marriage Law, Inheritance Law, Benefaction Abstrak.Kompilasi Hukum Islam merupakan salah satu upaya untuk mengimplementasikan hukum Islam di Indonesia secara konstitusional. Kompilasi Hukum Islam mencakup tiga bidang hukum, yaitu perkawinan, waris dan wakaf. Kompilasi Hukum Islam memberikan kontribusi yang positif dalam memberikan kepastian hukum, khususnya untuk para hakim di pengadilan agama. Selain itu, masih ada beberapa masalah terkait Kompilasi Hukum Islam, yaitu masalah sosialisasi, persamaan persepsi dan adanya kekhawatiran tereduksinya hukum Islam.Kata Kunci: Kompilasi Hukum Islam, Hukum Perkawinan, Hukum Waris, Wakaf