bluuebunny/crossref_metadata_2025_split huggingface dataset:
MuSCA: a multi-scale model to explore carbon allocation in plants
Authors: Reyes F. , Pallas B. , Pradal C. , Vaggi F. , Zanotelli D. , Tagliavini M. , Gianelle D. , Costes E. 
Published: July 2018

ABSTRACTBackground and aimsCarbon allocation in plants is usually represented at a specific spatial scale, peculiar to each model. This makes the results obtained by different models, and the impact of their scale of representation, difficult to compare. In this work we developed a Multi Scale Carbon Allocation model (MuSCA) that can be applied at different, user-defined, topological scales of a plant, and used to assess the impact of each spatial scale on simulated results and computation time.MethodsModel multi-scale consistency and behavior were tested by applications on three realistic apple tree structures. Carbon allocation was computed at five spatial scales, spanning from the metamer (the finest scale, used as a reference) up to 1st order branches, and for different values of a sap friction coefficient. Fruit dry mass increments were compared across spatial scales and with field data.Key ResultsThe model showed physiological coherence in representing competition for carbon assimilates. Results from intermediate values of the friction parameter best fitted the field data. For these, fruit growth simulated at the metamer scale (considered as a reference) differed from about 1% at growth unit scale up to 35% at first order branch scale. Generally, the coarser the spatial scale the more fruit growth diverged from the reference and the lower the obtained within-tree fruit growth variability. Coherence in the carbon allocated across scales was also differently impacted, depending on the tree structure considered. Decreasing the topological resolution reduced computation time up to four orders of magnitude.ConclusionsMuSCA revealed that the topological scale has a major influence on the simulation of carbon allocation, suggesting that this factor should be carefully evaluated when using different carbon allocation models or comparing their results. Trades-off between computation time and prediction accuracy can be evaluated by changing topological scales.
Cis-topic modelling of single-cell epigenomes
Authors: González-Blas Carmen Bravo , Minnoye Liesbeth , Papasokrati Dafni , Aibar Sara , Hulselmans Gert , Christiaens Valerie , Davie Kristofer , Wouters Jasper , Aerts Stein 
Published: July 2018

AbstractSingle-cell epigenomics provides new opportunities to decipher genomic regulatory programs from heterogeneous samples and dynamic processes. We present a probabilistic framework called cisTopic, to simultaneously discover “cis-regulatory topics” and stable cell states from sparse single-cell epigenomics data. After benchmarking cisTopic on single-cell ATAC-seq data, single-cell DNA methylation data, and semi-simulated single-cell ChIP-seq data, we use cisTopic to predict regulatory programs in the human brain and validate these by aligning them with co-expression networks derived from single-cell RNA-seq data. Next, we performed a time-series single-cell ATAC-seq experiment after SOX10 perturbations in melanoma cultures, where cisTopic revealed dynamic regulatory topics driven by SOX10 and AP-1. Finally, machine learning and enhancer modelling approaches allowed to predict cell type specific SOX10 and SOX9 binding sites based on topic specific co-regulatory motifs. cisTopic is available as an R/Bioconductor package at http://github.com/aertslab/cistopic.
Porcine circovirus 2 uses a multitude of weak binding sites to interact with heparan sulfate, and the interactions do not follow the symmetry of the capsid
Authors: Dhindwal Sonali , Avila Bryant , Feng Shanshan , Khayat Reza 
Published: July 2018

AbstractPorcine circovirus 2 is the smallest pathogenic virus capable of autonomous replication within its host. Infections result in immunosuppression and subsequent death of the host, and are initiated via the attachment of the PCV2 icosahedral capsid to heparan sulfate and chondroitin sulfate B glycosaminoglycans on the cell surface. However, the underlying mechanism of structural recognition remains to be explored. Using heparin, a routinely used analog of heparan sulfate, we demonstrate that increasing lengths of heparin exhibit greater affinity towards PCV2. Our competition assays indicate that dextra sulfate (8kDa) has higher affinity than heparin (12kDa), chondroitin sulfate B (41kDa) hyaluronic acid (1.6MDa), and dextran (6kDa) for PCV2. This suggests that polymers high in sulfate content are capable of competing with the PCV2-heparan sulfate interaction, and thus have the potential to inhibit PCV2 infection. Finally, we visualize the interaction between heparin and the PCV2 capsid using cryo-electron microscopy single particle analysis, symmetry expansion, and focused classification. The image reconstructions provide the first example of an asymmetric distribution of heparin on the surface of an icosahedral virus capsid. We demonstrate that each of the 60 capsid subunits that generate theT=1 capsid can bind heparin via one of five binding sites. However, not all of the binding sites are occupied by heparin and only one-to two-thirds of the binding sites are occupied. The binding sites are defined by arginine, lysine, and polar amino acids. Mutating the arginine, lysine, and polar amino acids to alanine diminishes the binding capacity of PCV2 to heparin.ImportanceIt has been demonstrated that porcine circovirus 2 (PCV2) attaches to cells via heparan sulfate (HS) and chondroitin sulfate B (CSB) glycosaminoglycans; however, the underlying structural mechanism describing the HS/CSB recognition by PCV2 remains to be explored. We use cryo-electron microscopy with single particle analysis, symmetry expansion, and focused classification to visualize the interaction between the PCV2 capsid and heparin, an analog of heparan sulfate, to better than 3.6Å resolution. We observe that the interaction between the PCV2 and heparin does not adhere to the icosahedral symmetry of the capsid. To the best of our knowledge, this is the first example where the interaction between heparin and an icosahedral capsid does not follow the symmetry elements of the capsid. Our findings also suggest that anionic polymers such as dextran sulfate may act to inhibit PCV2 infection.
Understanding customer requirements of corrugated industry using Kano model
Authors: Gupta Mahima , Shri Charu 
Published: July 2018

Purpose
The purpose of this paper is to illuminate concerned companies to develop a better understanding of customer needs through reference of Kano model.

Design/methodology/approach
This paper facilitates decision-making process for the productive use of strategy management through a case study approach for corrugated industries in India. A hybrid approach is employed by calculating coefficients of satisfaction with S-CR (customer requirements and customer satisfaction (CS)) relationship functions and self-stated importance evaluation.

Findings
Kano’s model provides an effective approach for both industries and academic research in classifying different customer requirements into different categories based on their impact on CS. It empowers to obtain competitive and factual information about customer needs.

Research limitations/implications
This study is limited in terms of sample size, domain of the study and the coverage of participants.

Originality/value
This paper suggests a valuable Kano approach for concerned organizations and practitioners, to correctly identify customer requirements and channelize their resources in right direction. Fulfilling customer requirements by providing them satisfaction and delight timely is only golden rule for sustaining in this competitive world.
Social enterprises in Palestine: a critical analysis
Authors: Akella Devi , Eid Niveen 
Published: July 2018

Purpose
This paper aims to critically examine the concept of social enterprises in Palestine. It uses the lens of institutional theory to understand how the political and economic context of the society can influence certain types of entrepreneurial behaviors and be responsible for the emergence of social enterprises. The paper uses a critical perspective to deconstruct social enterprises in Palestine to shed light on reasons for their emergence, motives and agendas.

Design/methodology/approach
A case study design was used to examine the phenomenon of social enterprises. The case study method is valuable in describing the how and why issues of a phenomenon in the present time frame. Two leading social enterprises operating within the Palestinian region were identified. The two enterprises were contacted for a series of interviews (over a period of few months) with their owners and other active members.

Findings
The empirical findings suggest that social enterprise model is still in its embryonic stages in Palestine. Their social mission of community development and sustainability is not completely sincere. The social entrepreneurs were willing to compromise social mission for economic surplus. The national structure, political framework, legal environment, social, cultural and the economic conditions of Palestine have served as suitable launching pads for social enterprises with not so authentic mission of serving the society. It has encouraged entrepreneurial philosophy and behavior, which has masked hidden economic and political agendas with exterior goals of social welfare and community development.

Research limitations/implications
This paper adopts a critical perspective and a qualitative methodology, and this raises the concern if the arguments pertaining to social enterprise raised in this paper can sustain in a developed nation with a stabilized political scenario or whether this alternative ideology is only relevant to underdeveloped countries with unstable, political conditions, such as Palestine.

Practical implications
This paper provides relevant information for students, critical academics and policymakers.

Social implications
The paper argues for a more concise definition for the model of social enterprises. It argues for clear legal guidelines which could monitor the formation of social enterprises in Palestine.

Originality/value
This paper provides an alternative perspective on social enterprises within a constrained and political unstable economy of Palestine.
Walking the tightrope: gender inclusion as organizational change
Authors: Kulkarni Vaibhavi , Vohra Neharika , Sharma Supriya , Nair Nisha 
Published: July 2018

PurposeThe study focuses on the inclusion practices and processes of five large organizations across diverse sectors where women are underrepresented. The purpose of this paper is to examine how organizations facilitate changes in behavior and mindset through formal and informal practices.Design/methodology/approachIn-depth interviews of CEOs, HR team members, and diversity and inclusion leaders in the five organizations were used as data in this study. Coding was done over several rounds via content analysis for the development of themes around how organizations work toward women’s inclusion.FindingsThe findings indicate that in their inclusion practices, all five organizations took into consideration societal biases that often render women at a disadvantage. Some of the cultural biases regarding family role expectations and safety-related norms were recognized and incorporated in their practices, while other gender-based stereotypes impeding inclusivity were addressed with zero tolerance of prejudicial behaviors. Organizations achieved this balance through various communicative practices including lateral and informal communication, generalized and particularized conversations, and creation of alternate spaces for dialogue.Practical implicationsBy examining women’s inclusivity initiatives of five large organizations working in India, this study helps create an understanding of how organizations can bring about such change, keeping in mind the societal and cultural context, for a more nuanced and achievable inclusion. This study also demonstrates how informal narratives enable deep-rooted organizational change such as inclusion. Such narratives facilitate in enhancing employee’s readiness to change, thereby laying foundations for a sustained impact.Originality/valueVery few studies that focus on women’s inclusion practices also take into consideration both the demands of the organization as well as the societal expectations placed upon women. This study highlights how organizations try to manage this tension and refrain from “homogenizing” or fitting women into existing practices and routines.
No one rides for free! Three styles of collaborative consumption
Authors: Guyader Hugo 
Published: July 2018

Purpose
This paper aims to focus on collaborative consumption, that is, the peer-to-peer (P2P) exchange of goods and services facilitated by online platforms. Anchored in the access paradigm, collaborative consumption (e.g. accommodation rental and ridesharing services) differs from commercial services offered by firms (e.g. business-to-customer [B2C] carsharing). The aim of this study is to examine the nuanced styles of collaborative consumption in relation to market-mediated access practices and socially mediated sharing practices.

Design/methodology/approach
Following the general research trend on mobility services, the context of long-distance ridesharing is chosen. Data collection was conducted using participant observation as peer service provider, 11 ethnographic interviews of consumers and a netnographic study of digital artifacts.

Findings
Using practice theory, ten ridesharing activities were identified. These activities and the nuances in the procedures, understandings and engagements in the ridesharing practice led to the distinction of three styles of collaborative consumption: communal collaborative consumption, which is when participants seek pro-social relationships in belonging to a community; consumerist collaborative consumption, performed by participants who seek status and convenience in the access lifestyle; and opportunistic collaborative consumption, when participants seek to achieve monetary gain or personal benefits from abusive activities.

Originality/value
By taking a phenomenological approach on collaborative consumption, this study adds to the understanding of the sharing economy as embedded in both a utilitarian/commercial economic system and a non-market/communal social system. The three styles of collaborative consumption propose a framework for future studies differentiating P2P exchanges from other practices (i.e. B2C access-based services and sharing).
Adherence to Mediterranean dietary pattern in female adolescents
Authors: Neshatbini Tehrani Asal , Farhadnejad Hossein , Salehpour Amin , Moloodi Reza , Hekmatdoost Azita , Rashidkhani Bahram 
Published: July 2018

Purpose
To the best of our knowledge, the studies on determining adherence to the Mediterranean dietary pattern (MDP) in Iran as a non-Mediterranean country are scarce. Thus, the aim of the study is to determine the adherence to the MDP in a sample of female adolescents who are residents of Tehran, Iran.

Design/methodology/approach
In this cross-sectional study, 263 female adolescents aged 15-18 years were studied. Information on socio-demographic, lifestyle and anthropometric variables were obtained using a structured questionnaire. Also, dietary intakes were determined using a validated 168-item food frequency questionnaire. Adherence to MDP was characterized using Mediterranean-style dietary pattern score (MSDPS).

Findings
Typically, the mean ± SD MSDPS was low in the present study (15.9 ± 5.6). The mean ± SD age and body mass index of the study population was 16.2 ± 0.9 years and 22.2 ± 4.1 kg/m2, respectively. In this study, the maximum MSDPS was 34.3, which was only one-third of maximum possible score (100). Multiple linear regression analyses showed that higher MSDPS scores were positively associated with age (standardized β = 0.1; p = 0.006), higher energy intake (standardized β = 0.2; p < 0.001) and marginally higher physical activity (standardized β = 0.1; p = 0.079).

Originality/value
Understanding low adherence to MDP in Tehranian female adolescents can provide basic knowledge to launch systematic programmes for gravitation toward MDP.
The role of customer experience touchpoints in driving loyalty intentions in services
Authors: Ieva Marco , Ziliani Cristina 
Published: July 2018

Purpose
The explosion in the number of touchpoints is putting pressure on companies to design omnichannel customer experiences aimed at achieving long-term customer loyalty. The purpose of this paper is to examine the relative importance of 24 touchpoints in contributing to customer loyalty intentions.

Design/methodology/approach
Data were collected by means of a survey on almost 6,000 subjects belonging to the Nielsen consumer panel. Two ordinary least squares regression models with clustered standard errors estimate the relationship between touchpoint exposure – measured in terms of reach, frequency and positivity – and customer loyalty intentions in the mobile service sector.

Findings
Reach has a significant relationship with customer loyalty intentions as far as eight touchpoints are concerned. Positivity, when controlling for frequency of exposure, is related to customer loyalty intentions as far as nine touchpoints are concerned.

Practical implications
Results provide guidance for mobile service providers on customer experience management strategies and specifically on touchpoint prioritization, adaptation, monitoring and design.

Originality/value
This study addresses two relevant research gaps. First, most studies focus on single or a few touchpoints without considering the variety of touchpoints within the customer journey (Lemon and Verhoef, 2016). Second, no studies focus on the relative contribution of touchpoints to customer loyalty intentions (Homburg et al., 2017).
Effects of tumor necrosis factor‐α, interleukin‐23 and interleukin‐17A inhibitors on bodyweight and body mass index in patients with psoriasis
Authors: Takamura Saori , Takahashi Aya , Inoue Yumiko , Teraki Yuichi 
Published: July 2018

AbstractTreatment with tumor necrosis factor‐α inhibitors has been reported to cause weight gain in patients with psoriasis; however, limited information is available in terms of the effects of interleukin (IL)‐23 and IL‐17A inhibitors on bodyweight (BW) in patients with psoriasis. This study aimed to investigate the effects of infliximab, ustekinumab and secukinumab on BW and body mass index (BMI) in patients with psoriasis. We retrospectively examined changes in BW and BMI among patients treated with these biologics at our hospital. At baseline, no significant differences in BW and BMI were observed among the patients treated with infliximab (n = 18), ustekinumab (n = 30) or secukinumab (n = 20). After 7 months of the therapy, significant increases in mean BW (from 71.4 to 74.3 kg) and mean BMI (from 24.7 to 25.7) were observed in the patients treated with infliximab, whereas no significant changes were observed in those treated with ustekinumab (BW, from 70.3 to 70.1 kg; BMI, from 25.4 to 25.3) or secukinumab (BW, from 69.0 to 68.9 kg; BMI, from 25.2 to 25.2). There were no differences in the proportion of the patients who showed 75% or more improvement in the Psoriasis Area and Severity Index among the three groups. These results suggest that infliximab increases BW in the patients with psoriasis, whereas ustekinumab and secukinumab do not affect the BW in these patients.
Patients with urticaria are at a higher risk of anaphylaxis: A nationwide population‐based retrospective cohort study in Taiwan
Authors: Yong Su‐Boon , Chen Huang‐Hsi , Huang Jing‐Yang , Wei James Cheng‐Chung 
Published: July 2018

AbstractThe clinical features of urticaria and anaphylaxis are similar, and they share common causal immune‐mediated pathways. We aimed to investigate the risk of anaphylaxis among patients with urticaria. A 12‐year population‐based retrospective cohort study was conducted. Investigated subjects were identified from the Taiwan National Health Insurance Research Database by the International Classification of Disease, Ninth Revision, Clinical Modification. We included 126 031 subjects with newly diagnosed urticaria and 252 062 matched controls between 2000 and 2013. Risk of anaphylaxis among patients with urticaria was calculated by calculating adjusted hazards ratios (HR) after matching for confounding comorbidities. Urticaria was more common in women than it was in men (58% vs 42%), with a peak onset age of 20–40 years. The number of comorbidities including asthma, allergic rhinitis, herpes zoster, hepatitis B and C, rheumatoid arthritis and gout were higher in patients with urticaria than that in age‐ and sex‐matched controls. The crude HR for anaphylaxis among urticaria subjects was 2.883 (95% confidence interval [CI], 2.787–2.982; P < 0.001). After adjustment for potential confounders which have been proposed to increase the risk of anaphylaxis, patients with urticaria were found to be at a significantly high risk of anaphylaxis with an adjusted HR of 2.529 (95% CI, 2.442–2.619; P < 0.001). We conclude that the incidence rate of anaphylaxis is significantly high in patients with urticaria in Taiwan.
Do we need a core outcome set for childbirth perineal trauma research? A systematic review of outcome reporting in randomised trials evaluating the management of childbirth trauma
Authors: Pergialiotis V , Durnea C , Elfituri A , Duffy JMN , Doumouchtsis SK ,   International Collaboration for Harmonising Outcomes, Research, and Standards in Urogynaecology and Women's Health (CHORUS)
Published: July 2018

BackgroundSelecting appropriate outcomes to reflect both beneficial and harmful effects is a critical step in designing childbirth trauma trials.ObjectiveTo evaluate the outcomes and outcome measures reported in randomised controlled trials evaluating interventions for childbirth trauma.Search strategyRandomised trials were identified by searching bibliographical databases including the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and EMBASE.Selection criteriaRandomised trials evaluating the efficacy and safety of different techniques in the management of perineal lacerations.Data collection and analysisTwo researchers independently assessed studies for inclusion, evaluated methodological quality, and extracted the relevant data. Spearman's ρ correlation and multivariate linear regression analysis using the backward stepwise model were used for analysis.Main resultsForty‐eight randomised trials, reporting data from 20 308 women, were included. Seventeen different interventions were evaluated. Included trials reported 77 different outcomes and 50 different outcome measures. Commonly reported outcomes included pain (34 trials; 70%), wound healing (20 trials; 42%), and anorectal dysfunction (16 trials, 33%). In the multivariate analysis, no relationship was demonstrated between the quality of outcome reporting and year of publication (P = 0.31), journal impact factor (P = 0.49), and methodological quality (P = 0.13).ConclusionOutcome reporting in childbirth trauma research is heterogeneous. Developing, disseminating, and implementing a core outcome set in future childbirth trauma research could help address these issues.Tweetable abstractDeveloping @coreoutcomes for childbirth trauma research could help to reduce #research waste.