bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Temporomandibular Disorders, Anxiety, and Sleep Quality in Dental Students: A Cross-Sectional Study
Authors: Dere Kadriye Ayça 
Published: November 2024

Abstract

Background
This study aimed to measure the frequencies of stress, anxiety, sleep quality, and temporomandibular joint disorder (TMD) among dental students and evaluate their relationships.
Methods
A cross-sectional survey was conducted among dentistry students studying at dental schools in Turkey. Participating students were administered a survey consisting of the Fonseca Anamnestic Index (FAI) to evaluate TMD; the Depression Anxiety Stress Scale (DASS)-21 to evaluate depression, anxiety, and stress; and the Pittsburgh Sleep Quality Index (PSQI) to evaluate sleep quality. Analysis methods included descriptive statistics, the Kruskall–Wallis H test, the Mann–Whitney U Test, and Spearman’s rank correlation coefficient.
Results
This survey included 1162 dental students, including 824 (70.91%) females, 333 (28.66%) males, and 5 (0.43%) LGBTIQA + individuals. The FAI (p < 0.001) and DASS-21 anxiety (p < 0.001) and stress (p < 0.007) scores were significantly higher in females than males. The global PSQI scores were significantly higher in males than females (p < 0.007). The FAI scores (p < 0.001); DASS-21 depression (p < 0.001), anxiety (p < 0.001), and stress (p < 0.001) scores; and global PSQI scores (p = 0.002) differed significantly by grade.
Conclusions
Stress, anxiety, and depression contribute to the development of TMD. Females experience greater TMD, stress, anxiety, and depression during their education life, while males have a worse sleep quality. TMD, anxiety, depression, and stress levels are lowest at the start of the training and increase over the years as theoretical and practical training progresses.
Repurposed Drugs as PCSK9-LDLR Disruptors for Lipid Lowering and Cardiovascular Disease Therapeutics
Authors: Aggarwal Shelly Singhal  nee , Kaur Divpreet , Saluja Daman , Srivast Kamna 
Published: November 2024

Abstract

The PCSK9 protein binds to LDL receptors (LDLR), leading to their degradation and reduced expression on cell surfaces. This decreased clearance of LDL cholesterol from bloodstream, thereby increasing the risk of coronary artery diseases. Targeting the PCSK9-LDL receptor interaction is crucial for regulating LDL cholesterol levels and preventing cardiovascular disease. This study aims to screen low molecular weight inhibitors to disrupt the PCSK9-LDLR interaction. We employed a comprehensive approach combining high throughput virtual screening of DrugBank database, followed by molecular docking studies using CDOCKER and flexible docking methods. The top four lead compounds were further validated through molecular dynamics (MD) simulations and binding free energy calculations using MM-PBSA. Finally, the in-vitro assay confirmed the Benazepril and Quinapril exhibiting the highest potency as PCSK9-LDLR disruptor amongst the top candidates. These lead compounds have the potential to be repurposed as lipid-lowering agents for the treatment of cardiovascular diseases, offering a promising therapeutic strategy.
RNA N6-Methyladenosine (m6A) regulates the cell cycle in Diffuse Midline Glioma (DMG) and confers sensitivity to FTO inhibition
Authors: Ross Samuel E. , Holliday Holly , Wang Eyden , Zeraati Mahdi , Tsoli Maria , Ziegler David S. , Dinger Marcel E. 
Published: November 2024

Abstract

Background: Diffuse Midline Gliomas (DMG) are deadly pediatric brain cancers with limited treatment options. These tumors likely arise from oligodendrocyte precursor cells (OPC) that acquire a driver histone mutation, leading to an aberrant epigenome. RNA N6-methyladenosine (m6A) is a vital epi-transcriptomic modification that regulates RNA processes and plays a significant role in OPC development through its regulation of transcripts involved in histone modification processes. Despite this pivotal role in OPC biology, the epi-transcriptome has not yet been investigated in DMG, and its interrogation may uncover new therapeutic options and improve our understanding of this disease.
Results: Therefore, for the first time, we generated base-resolution m6A landscapes for patient-derived DMG cultures and revealed a critical role in cell cycle regulation. We also found that DMG is sensitive to the inhibition of the m6A demethylase Fat Mass and Obesity Associated (FTO), with this inhibition leading to decreased survival and S-phase arrest/stress. Additionally, key cell cycle regulators, such as PLK1, are m6A-modified, contain YTHDF2 binding sites, and show significant changes following FTO inhibition on transcriptomic and proteomic levels.
Conclusions: Here, we provide the first epi-transcriptomic and m6A resource for DMG and reveal a crucial link between m6A modifications and cell cycle regulation. Furthermore, we show that this relationship confers sensitivity to the inhibition of the m6A demethylase FTO, with inhibition resulting in decreased survival and cell-cycle dysregulation. Collectively, these findings highlight the epi-transcriptome and its regulators as promising therapeutic targets for this currently uncurable disease.
Effect of dapagliflozin on rat and human cardiac fibroblasts physiology cultured in diabetic media conditions
Authors: Wilfred Obaalologhi 
Published: November 2024

Abstract

Heart failure (HF) is a disease caused by defects in myocardial structure and function which results to impaired ventricular filling of the ejection of blood, and mostly due to reduced myocardial function of the left ventricle, impairment of the myocardium, endocardium, great vessels, pericardium, heart valves, either in combination or alone, presenting symptoms which include fatigue, oedema, shortness of breath, abdominal distention and right hypochondrial pain. HF, which is classed into HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) has been linked to elevated glucose levels seen in diabetic patients, which is also linked to increased fibrosis which impacts on myocardial function. Unfortunately, no effective drug is yet developed for the treatment HFpEF. In the current study, I investigated the effect of dapagliflozin (dapa) on cardiac fibroblasts (CFs) physiology in diabetic media conditions using rat cardiac fibroblasts (RcFbs) and human cardiac fibroblasts (HcFbs). Experiments were performed to study the effects of elevated glucose with/without dapa on gene expressions of human collagen-1 (col1a2), calcium/calmodulin-dependent protein kinase II delta (CAMK2D) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) using quantitative polymerase chain reaction (qPCR), Ca2+ release and migration and proliferation assays of CFs were assessed using confocal microscopy and countess counter. Our study demonstrates that dapa has a potential in wound healing, and has been shown to increase Ca2+ mobilization in diabetic cultured cells. Although dapa impaired col1a2 expression in diabetic condition, it showed no significant change on CAMK2D expression in diabetic conditions. The implication of these findings suggests that dapa could be a potentially therapeutic agent in treating HF as it has been shown to improve wound healing (via the scratch assay), increased proliferation of cells and increased col1a2 expression.
Impacts of the road on flood inundation in the Tra Khuc–Ve River basin, Vietnam
Authors: Vu Huy Cong , To Thuy Nga , Le Hung 
Published: November 2024

ABSTRACT

Building new roads has the potential to change the natural patterns of flood flow and increase the risk of flooding in adjacent areas. This study investigated the effects of an expressway on the change in flood inundation in the Tra Khuc–Ve River basin in Vietnam. Because of the presence of reservoirs in the study area, various hydraulic, hydrological, and reservoir operational models were employed. Regarding flood flow, scenarios with frequencies of 1, 3, 5, 10, and 20% were used. The comparison of simulated and observed flood trace data shows good agreement. The distribution of floods has changed a lot, as shown in the inundation maps. The new expressway has caused serious flooding in some areas. The water level difference between the two sides of the road can be as high as 2 m. The flooding duration at several locations increased by many hours. In addition, several structural measures are also suggested to lessen the effects of floods, such as dredging rivers, constructing flood drainage canals, and adding more culverts. Lastly, shortcomings in Vietnam's road construction guidelines in flood zones are also mentioned.
A Relationship Assessment Between Environmental Practices, Corporate Value, and CSR in Sustainability Context
Authors: Astuti Tri , Magdalena Maria , Mandagie Yuana Rizky , Irawan Tedhi 
Published: November 2024

AbstractThis study examines the influence of environmental performance disclosure within corporate social responsibility on company value. It assesses the impact of green intellectual capital (human, structural, and relational), green innovation (product and process), carbon emission disclosure, and eco-efficiency on Price Book Value (PBV). The sample includes 11 companies from the Sri Kehati Index 2018-2022, which apply Sustainable Responsible Investment (SRI) and ESG principles. Using multiple regression analysis, the findings reveal that green intellectual capital disclosure does not significantly affect company value. However, green innovation positively impacts PBV, suggesting its importance in enhancing corporate valuation. In contrast, carbon emission disclosure and eco-efficiency are found to negatively influence PBV. These results highlight the critical role of green innovation in driving company value while suggesting that certain environmental disclosures may lower valuations. The study provides valuable insights into how environmental practices affect corporate value within the framework of corporate social responsibility and sustainability. Keywords:Green Intellectual Capital, Green Innovation, Carbon Emissions Disclosure, Eco-Efficiency, Company Value
Understanding Providers’ Attitude Toward AI in India’s Informal Health Care Sector: Survey Study
Authors: Kumar Sumeet , Rayal Snehil , Bommaraju Raghuram , Varasala Navya Pratyusha , Papineni Sirisha , Deo Sarang 
Published: November 2024

Abstract

Background
Tuberculosis (TB) is a major global health concern, causing 1.5 million deaths in 2020. Diagnostic tests for TB are often inaccurate, expensive, and inaccessible, making chest x-rays augmented with artificial intelligence (AI) a promising solution. However, whether providers are willing to adopt AI is not apparent.

Objective
The study seeks to understand the attitude of Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homoeopathy (AYUSH) and informal health care providers, who we jointly call AIPs, toward adopting AI for TB diagnosis. We chose to study these providers as they are the first point of contact for a majority of TB patients in India.

Methods
We conducted a cross-sectional survey of 406 AIPs across the states of Jharkhand (162 participants) and Gujarat (244 participants) in India. We designed the survey questionnaire to assess the AIPs’ confidence in treating presumptive TB patients, their trust in local radiologists’ reading of the chest x-ray images, their beliefs regarding the diagnostic capabilities of AI, and their willingness to adopt AI for TB diagnosis.

Results
We found that 93.7% (270/288) of AIPs believed that AI could improve the accuracy of TB diagnosis, and for those who believed in AI, 71.9% (194/270) were willing to try AI. Among all AIPs, 69.4% (200/288) were willing to try AI. However, we found significant differences in AIPs’ willingness to try AI across the 2 states. Specifically, in Gujarat, a state with better and more accessible health care infrastructure, 73.4% (155/211) were willing to try AI, and in Jharkhand, 58.4% (45/77) were willing to try AI. Moreover, AIPs in Gujarat who showed higher trust in the local radiologists were less likely to try AI (odds ratio [OR] 0.15, 95% CI 0.03‐0.69; P=.02). In contrast, in Jharkhand, those who showed higher trust in the local radiologists were more likely to try AI (OR 2.11, 95% CI 0.9‐4.93; P=.09).

Conclusions
While most AIPs believed in the potential benefits of AI-based TB diagnoses, many did not intend to try AI, indicating that the expected benefits of AI measured in terms of technological superiority may not directly translate to impact on the ground. Improving beliefs among AIPs with poor access to radiology services or those who are less confident of diagnosing TB is likely to result in a greater impact of AI on the ground. Additionally, tailored interventions addressing regional and infrastructural differences may facilitate AI adoption in India’s informal health care sector.
The Doctors, Their Patients, and the Symptom Checker App: Qualitative Interview Study With General Practitioners in Germany
Authors: Preiser Christine , Radionova Natalia , Ög Eylem , Koch Roland , Klemmt Malte , Müller Regina , Ranisch Robert , Joos Stefanie , Rieger Monika A 
Published: November 2024

Background
Symptom checkers are designed for laypeople and promise to provide a preliminary diagnosis, a sense of urgency, and a suggested course of action.

Objective
We used the international symptom checker app (SCA) Ada App as an example to answer the following question: How do general practitioners (GPs) experience the SCA in relation to the macro, meso, and micro level of their daily work, and how does this interact with work-related psychosocial resources and demands?

Methods
We conducted 8 semistructured interviews with GPs in Germany between December 2020 and February 2022. We analyzed the data using the integrative basic method, an interpretative-reconstructive method, to identify core themes and modes of thematization.

Results
Although most GPs in this study were open to digitization in health care and their practice, only one was familiar with the SCA. GPs considered the SCA as part of the “unorganized stage” of patients’ searching about their conditions. Some preferred it to popular search engines. They considered it relevant to their work as soon as the SCA would influence patients’ decisions to see a doctor. Some wanted to see the results of the SCA in advance in order to decide on the patient’s next steps. GPs described the diagnostic process as guided by shared decision-making, with the GP taking the lead and the patient deciding. They saw diagnosis as an act of making sense of data, which the SCA would not be able to do, despite the huge amounts of data.

Conclusions
GPs took a techno-pragmatic view of SCA. They operate in a health care system of increasing scarcity. They saw the SCA as a potential work-related resource if it helped them to reduce administrative tasks and unnecessary patient contacts. The SCA was seen as a potential work-related demand if it increased workload, for example, if it increased patients’ anxiety, was too risk-averse, or made patients more insistent on their own opinions.
Generative AI’s Performance on Emergency Medicine Boards Questions: Observational Study (Preprint)
Authors: Kajitani Sten , Pastrak Mila , Goodings Anthony , Drewek Austin , Lafree Andrew , Murphy Adrian 
Published: November 2024

BACKGROUND

The ever evolving field of medicine has highlighted the potential for ChatGPT as an
assistive platform. However, its use in medical board exam preparation and completion remains divided.

OBJECTIVE

This study aimed to evaluate the performance of a custom-modified version of ChatGPT-4,
tailored with emergency medicine board exam preparatory materials (Anki deck), compared to its default
version and previous iteration (3.5). The goal was to assess the accuracy of ChatGPT-4 answering board-
style questions and its suitability as a tool for medical education.

METHODS

A comparative analysis was conducted using a random selection of 598 questions from the
Rosh In-Training Exam Question Bank. The subjects of the study included three versions of ChatGPT:
the Default, a Custom, and ChatGPT-3.5. Accuracy, response length, medical discipline subgroups, and
underlying causes of error were analyzed.

RESULTS

Custom did not demonstrate a significant improvement in accuracy over Default (p>0.05),
though both significantly outperformed ChatGPT-3.5 (p<0.05). Default produced significantly longer
responses than the Custom (p<0.05). Subgroup analysis revealed no significant difference in the
performance across different medical sub-disciplines between the versions (p>0.05). Both ChatGPT-4’s
had similar underlying errors (p>0.05) and had a 99% predicted probability of passing while ChatGPT-
3.5 had an 85%.

CONCLUSIONS

The findings suggest that while newer versions of ChatGPT exhibit improved performance
in emergency medicine board exam preparation, specific enhancements do not significantly impact
accuracy. The study highlights the potential of ChatGPT-4 as a tool for medical education, capable of
providing accurate support across a wide range of topics in emergency medicine.
Bibliotecas públicas e a memória
Authors: Morais Costa Maurício José , Guedes Cutrim Kláutenys Dellene 
Published: November 2024

Estudo que tem por objetivo discutir a prática interdisciplinar do bibliotecário nos serviços educativos da Biblioteca Pública Benedito Leite, bem como suas contribuições para a preservação da memória e do patrimônio cultural ludovicense e maranhense. Seu desenho metodológico revela uma pesquisa exploratória, de abordagem qualitativa, cujos sujeitos da pesquisa incluiu duas turismólogas e uma bibliotecária. Os dados foram obtidos por meio de entrevistas semiestruturadas para analisar como os serviços são planejados, quais as ambições da instituição em sua realização, as expectativas, bem como os desdobramentos deles nas ações da Benedito Leite em São Luís e no Maranhão. Aborda patrimônio, memória, bibliotecas públicas de acordo com os estudos de Schneider (2018), Silveira (2012; 2014), Choay (2006), Pollak (1989; 1992), Milanesi (2003), Nora (1993), Almeida Júnior (2013; 1997), Candau (2016), Sousa (2015), Flusser (1983), Cardoso (2013), dentre outros. Desvela que a Benedito Leite busca cumprir seu papel na sociedade maranhense, para além das práticas e demandas comuns às bibliotecas públicas. Acentua que a sensibilidade e atuação interdisciplinar entre a bibliotecária responsável pela direção e as turismólogas da BPBL imprimem em seus setores para planejar e realizar os serviços ofertados pela instituição são fundamentais para que as missões das bibliotecas públicas sejam concretizadas.
Panorama das modalidades de acesso em RIs
Authors: Freitas Elaine Cristina , Fernandes de Oliveira Miranda Májory Karoline 
Published: November 2024

O acesso aberto à informação, norteado em duas estratégias: a Via Dourada (Golden Road) e a Via Verde (Green Road), instituiu um novo paradigma na comunicação científica, até então dominada por editores científicos comerciais. A abertura do acesso à informação científica possibilitou, quase que imediato, que os resultados de pesquisas acadêmicas contidas nos trabalhos de conclusão de cursos de graduação, dissertações e teses que agora estão armazenados nos Repositórios Institucionais das Universidades, fossem acessados pela comunidade científica em geral. O objetivo da pesquisa é apresentar um panorama das modalidades de acesso aplicadas nos documentos submetidos nos Repositórios institucionais das universidades federais brasileiras. Quanto aos métodos, a pesquisa é classificada como descritiva e utilizou a técnica pesquisa documental. O universo da pesquisa é composto pelas 22 Universidades Federais de Ensino Superior no Brasil, que atenderam ao Edital FINEP/PCAL/XBDB 002/2009 e ainda que na atualidade possuem política de informação do repositório. Os dados foram coletados por meio da análise das homepages das bibliotecas centrais, sítios dos repositórios, documentos oficiais das Universidades (portarias, manuais, termo de autorização de depósito). Os resultados indicam que as modalidades de acesso aos documentos depositados nos repositórios dessas instituições variam quanto à temporalidade, a proporção do texto que pode ser embargado e os tipos de licenças públicas aplicadas.
Práticas Informacionais no uso de Tecnologia da informação e Comunicação (TICs) para o Arranjo Produtivo Local de Londrina e Região - APL
Authors: Shirado Luciana Yuri , Gorri Molina Letícia 
Published: November 2024

Com o desenvolvimento das tecnologias da informação e comunicação (TICs), vivencia-se de forma proeminente a valorização da informação nas relações pessoais, empresariais e institucionais, mediadas por sistemas, as quais, aumentam exponencialmente em volume e disseminação. Este cenário impacta de forma direta o processo de busca, localização, acesso, recuperação e organização dos recursos informacionais. No entanto, identifica-se a ausência de tratamentos adequados no processo de representação informacional desses conteúdos. Assim, o referido artigo aborda a temática da Prática Informacional, com vistas a compreender a relevância do tema para ambientes coletivos, como o Arranjo Produtivo Local de Londrina e Região. Pretendeu-se mapear e analisar as perspectivas aplicáveis e existentes no referido grupo social. Com uma metodologia baseada na análise exploratória e descritiva do tema a partir da literatura disponível, apresenta-se uma análise de Práticas Informacionais como uma nova proposta para organização dos recursos informacionais, e que permitam a aplicabilidade de ferramentas tecnológicas que permeiam sua construção com base nas experiências dos sujeitos envolvidos no processos de produção e uso das informações.
conceito de informação, memória e sociedade à luz da análise de conteúdo
Authors: Carvalho de Oliveira Souza Irma Gracielle , Alembert Alexandre , de Medeiros Matos Autran Marynice , Juvenal Freire de Oliveira Bernardina Maria 
Published: November 2024

Trata-se de um estudo exploratório, cuja técnica de análise utilizada tanto para coleta, quanto para a análise dos dados, foi a Análise de Conteúdo proposta por Bardin (2010). Para atender o objetivo central desse estudo, que consistiu em analisar as categorias Informação, Memória e Sociedade à luz das obras: Tempos líquidos de Sigmund Bauman e Por uma outra globalização: do pensamento único à consciência universal de Milton Santos, estudadas na disciplina que leva o mesmo nome, ofertada pelo PPGCI/UFPB. A partir da análise realizada nos fichamentos, chegou-se ao seguinte resultado: Capital, capitalismo, comércio, comunidade, cultura, desordem, estado, globalização, identidade, individualismo, informação, medo, memória, mercadorias, pobreza e sociedade. Foram os termos que mais se repetiram durante o processo de análise das citações. Assim, com base nesses termos, chegou-se à seguinte conclusão, a informação é o elemento fundamental no processo de globalização e que o uso inadequado desta, aumenta a sensação de insegurança e desordem social. Haja vista, o caráter individualista da sociedade contemporânea. Assim, a construção da identidade, dá-se a partir do conhecimento da cultura local, bem como da ideia de pertencimento. Por outro lado, as ações violentas do estado, bem como sua tentativa d eximir de certas responsabilidades, conduzem a comunidade a uma vida baseada no medo, já que uma característica marcante, é a internacionalização do capital financeiro, através da comercialização de mercadorias, produtos e serviços, gerados por grandes empresas multinacionais.

Palavras-chave: Informação. Memória. Sociedade. Análise de conteúdo