bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of sexually-transferred steroids and mating-induced phenotypes in Anopheles mosquitoes
Authors: Pondeville Emilie , Puchot Nicolas , Lang Michael , Cherrier Floriane , Schaffner Francis , Dauphin-Villemant Chantal , Bischoff Emmanuel , Bourgouin Catherine 
Published: March 2019

AbstractHuman malaria, which remains a major public health problem, is transmitted by a subset of Anopheles mosquitoes belonging to only three out of eight subgenera: Anopheles, Cellia and Nyssorhynchus. Unlike almost every other insect species, males of some Anopheles species produce steroid hormones which are transferred to females during copulation to influence their reproduction. Steroids are consequently a potential target for malaria vector control. Here, we analysed the evolution of sexually-transferred steroids and their effects on female reproductive traits across Anopheles by using a set of 16 mosquito species (five Anopheles, eight Cellia, and three Nyssorhynchus), including malaria vector and non-vector species. We show that male steroid production and transfer are specific to the Cellia and therefore represent a synapomorphy of this subgenus. Furthermore, we show that mating-induced effects in females are variable across species and differences are not correlated with sexually-transferred steroids or with Anopheles ability to transmit human malaria. Overall, our findings highlight that Anopheles mosquitoes have evolved different reproductive strategies, independently of being a malaria vector or not.
Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes
Authors: Andersson Christian Rungsted , Falsig Jeppe , Stavenhagen Jeffrey B. , Christensen Søren , Kartberg Fredrik , Rosenqvist Nina , Finsen Bente , Pedersen Jan Torleif 
Published: March 2019

AbstractNeurodegenerative diseases such as Alzheimer’s disease are characterized by the progressive spreading and accumulation of hyper-phosphorylated tau protein in the brain. Anti-tau antibodies have been shown to reduce tau pathology in in vivo models and antibody-mediated clearance of tau exerted by microglia has been proposed as a contributing factor. By subjecting primary microglia cultured in vitro to anti-phospho-tau antibodies in complex with pathological tau, we show that microglia internalise and degrade tau in a manner that is dependent on FcγR interaction and functional lysosomes. It has recently been discussed if anti-tau antibody effector-functions are required for induction of tau clearance. Using antibodies with compromised FcγR binding and non-compromised control antibodies we show that antibody effector functions are required for induction of microglial clearance of tau. Understanding the inflammatory consequences of targeting microglia using therapeutic antibodies is important when developing these molecules for clinical use. Using RNA sequencing, we show that treatment with anti-tau antibodies increases transcription of mRNA encoding pro-inflammatory markers, but that the mRNA expression profile of antibody-treated cells differ from the profile of LPS activated microglia. We further demonstrate that microglia activation alone is not sufficient to induce significant tau clearance.
The emerging role of sorting nexins in cardiovascular diseases
Authors: Yang Jian , Villar Van Anthony M. , Rozyyev Selim , Jose Pedro A. , Zeng Chunyu 
Published: March 2019

Abstract
The sorting nexin (SNX) family consists of a diverse group of cytoplasmic- and membrane-associated phosphoinositide-binding proteins that play pivotal roles in the regulation of protein trafficking. This includes the entire endocytic pathway, such as endocytosis, endosomal sorting, and endosomal signaling. Dysfunctions of SNX pathway are involved in several forms of cardiovascular disease (CVD). Moreover, SNX gene variants are associated with CVDs. In this review, we discuss the current knowledge on SNX-mediated regulatory mechanisms and their roles in the pathogenesis and treatment of CVDs.
Synthesis of MnO/cotton based carbon composites as lithium‐ion battery anodes: a study on their structures and properties
Authors: Zhao Chenhao , Li Ling 
Published: March 2019

The construction of transition metal oxides/carbon composites has been one of the most useful methods to improve the electrochemical performances of transition metal oxides as anodes of lithium‐ion batteries (LIBs). It has been found that various carbon amounts will make a great effect on the structures and properties of composites. In this work, the MnO/cotton based carbon composites are immediately obtained at an inert atmosphere from Mn(NO3)2–cotton mixture, which is readily produced based on the adsorption characteristic of cotton. The influences of carbon contents derived from various cotton amounts on the structures and electrochemical properties of MnO are studied. The results show that decreased crystallinity and improved porous properties can be achieved with increased carbon contents. As LIBs anodes, their electrochemical behaviours are distinct and deeply influenced by carbon contents. The MnO/cotton based carbon composite obtained at a cotton amount of 0.3 g delivers an initial reversible discharge capacity of 812.4 mAh g−1, and a capacity of 775.9 mAh g−1 can be retained after 50 cycles. Meanwhile, the structure–function relation is also discussed in the text.
Parasitic coupled microstrip antenna using shared aperture technique
Authors: Dhiman Jonny , Kumar Khah Sunil 
Published: March 2019

Shared aperture based 2 × 2 matrix shaped patch antenna is described here. The 2 × 2 matrix based patch antenna with optimised dimensions is designed from a rotated hollow square shape based patch. Out of four elements, two diagonally placed elements are acting as resonating elements (for L‐band and S‐band separately); rest two acting as parasitic elements. The proposed prototype has a measured impedance bandwidth of 1.54–1.7 GHz in L‐band (S11 <−10 dB) and 3.7–4.2 GHz in S‐band (S22 <−10 dB). Isolation is better than 20 dB in both cases, with reduced cross‐polarisation, due to the presence of the parasitic elements. Details of the proposed prototype and design procedure are given; the experimental results are also discussed along with potential advantages and applications. The proposed antenna is designed and fabricated using FR‐4 substrate (90 mm × 90 mm).
Synthesis and phase transition properties of VO2 (M) hollow spheres with large thermal hysteresis width
Authors: Zhang Yifu 
Published: March 2019

Thermochromic VO2 (M) has attracted increasing attention regarding the reduction of its thermal hysteresis width (ΔTc). However, little attention is paid to increase its ΔTc, which may have scientific importance and potential application in the future. Herein, VO2 (M) hollow spheres assembled by nanoparticles are successfully synthesised using NH4VO3 as the vanadium source by a template‐free method. Their diameters mainly range from 350 to 650 nm and thickness of shells is about 50 nm in average. The hydrothermal process plays a crucial role in the successful formation of VO2 (M) hollow spheres. The phase transition temperature (Tc) of VO2 (M) hollow spheres is about 63°C in the heating curve and 32°C in the cooling curve. The ΔTc of VO2 (M) hollow spheres reach as high as 31°C, which is distinctively higher than the reported values (ca. 5–20°C). The huge ΔTc may have potential applications in some fields in the future.
Survival rates of planets in open clusters: the Pleiades, Hyades, and Praesepe clusters
Authors: Fujii M. S. , Hori Y. 
Published: March 2019

Context. In clustered environments, stellar encounters can liberate planets from their host stars via close encounters. Although the detection probability of planets suggests that the planet population in open clusters resembles that in the field, only a few dozen planet-hosting stars have been discovered in open clusters.
Aims. We explore the survival rates of planets against stellar encounters in open clusters similar to the Pleiades, Hyades, and Praesepe and embedded clusters.
Methods. We performed a series of N-body simulations of high-density and low-density open clusters, open clusters that grow via mergers of subclusters, and embedded clusters. We semi-analytically calculated the survival rate of planets in star clusters up to ~1 Gyr using relative velocities, masses, and impact parameters of intruding stars.
Results. Less than 1.5% of close-in planets within 1 AU and at most 7% of planets with 1–10 AU are ejected by stellar encounters in clustered environments after the dynamical evolution of star clusters. If a planet population from 0.01–100 AU in an open cluster initially follows the probability distribution function of exoplanets with semi-major axis (ap) between 0.03 and 3 AU in the field discovered by RV surveys (∝ ap−0.6), the PDF of surviving planets beyond ~10 AU in open clusters can be slightly modified to ∝ ap−0.76. The production rate of free-floating planets (FFPs) per star is 0.0096–0.18, where we have assumed that all the stars initially have one giant planet with a mass of 1–13 MJup in a circular orbit. The expected frequency of FFPs is compatible with the upper limit on that of FFPs indicated by recent microlensing surveys. Our survival rates of planets in open clusters suggest that planets within 10 AU around FGKM-type stars are rich in relatively-young (≲10–100 Myr for open clusters and ~1–10 Myr for embedded clusters), less massive open clusters, which are promising targets for planet searches.
Éléments pour une psychopathologie de la révolte
Authors: Novello Samantha , da Costa Héloïse 
Published: March 2019

En développant une approche inter- et transdisciplinaire, adoptée depuis quelques années dans le domaine de la recherche bioéthique, l’article propose un « dialogue » critique entre la pratique clinique contemporaine et la phénoménologie de la révolte et de ses pathologies formulée dans l’œuvre philosophique et littéraire d’Albert Camus. La lecture des essais philosophiques du Prix Nobel de Littérature, et notamment de L’Homme révolté (Paris, 1951), « en filigrane » de la situation clinique de Théo, exposée dans la première partie de cette contribution, permet, dans la deuxième partie de l’article, de mettre quelques-unes es pistes thérapeutiques actuelles - de la thérapie neuropsychologique à celle de la psychologie systémique et de la psychologie clinique d’orientation psychodynamique - à l’épreuve de l’analyse camusienne de la psychopathologie de la révolte contemporaine.
Impact of Digitalization on the Industrial Enterprises Activities
Authors: Chudaeva A.A. , Mantulenko V.V. , Zhelev P. , Vanickova R. 
Published: March 2019

The relevance of the study is determined by the change of technological structure of the Russian economy: digital technologies are becoming an integral part of the fulfilling life of both individual and legal entities. The use of digital technologies in the activities of manufacturing enterprises allows them to become more competitive. However, the change in almost all processes of an enterprise because of digitalization simplifies some of them and reduces their cost but complicates others and makes them more expensive. In addition, the digitalization leads to the emergence of new processes at enterprises that often means the emergence of new risks and additional costs.
The purpose of this research is to study the impact of the digitalization on activities of industrial enterprises. Objectives of the study are: to study the concept of digitalization, areas of activity of industrial enterprises as well as consequences of the introduction of digital technologies into each of the activity area of industrial enterprises and the impact of digitalization on the results of a production enterprise.
Some Aspects of the Quality of Corporate Governance in Digital Economy
Authors: Polidi A.A. , Goukasyan Z.O. , Maslova I.A. , Fedorenko R.V. 
Published: March 2019

The relevance of this article is due to technological changes that are constantly introducing new characteristics, both in the global economic system and in the economy of individual fields of activity. The newest digital economy is significantly different from the traditional economy. A modern business environment requires constant adaptation of an entrepreneur to dynamically changing conditions at a strategic and tactical level.
The purpose of the article is to study aspects of the quality of corporate governance, taking into account the challenges of the digital economy.
The objectives of the study are: to identify the key elements of corporate governance and environmental factors affecting them; to determine the conditions and factors of the formation of economic interests in the corporate governance system for the purpose of improving the quality of corporate governance in the digital economy.
Thermographic Characteristics of the Diabetic Foot With Peripheral Arterial Disease Using the Angiosome Concept
Authors: Carabott Matthew , Formosa Cynthia , Mizzi Anabelle , Papanas Nikolaos , Gatt Alfred 
Published: March 2019

Abstract
Aim To compare temperature changes following a challenge of limb elevation, in 3 forefoot angiosomes between type 2 diabetes mellitus patients with and without peripheral arterial disease (PAD).
Methods Participans were categorized in a no PAD, mild PAD or severe PAD group. All underwent thermal imaging, then successive thermal images were taken at 1 min intervals after the lower limbs were elevated for 5 min. Thereafter, the lower limbs were lowered to the original position and imaged after 1 min. Mean temperatures of the hallux, medial and lateral forefoot were analysed by the angiosome concept.
Results Forty-two limbs were analysed. Mean resting temperatures of all angiosomes of participants with PAD were higher than those with no peripheral arterial disease. A significant difference in the mean initial temperature between the groups was found in the medial and lateral forefoot angiosomes (p=0.048, p=0.049 respectively), whilst at the hallux these temperatures were not significant (p=0.165). After limb elevation, the only significant difference was seen in the lateral foot area at 1 min (p=0.021).
Conclusions These results confirm that patients with PAD exhibit significantly higher forefoot temperatures, according to the angiosome concept. The challenge by foot elevation did not affect the thermal pattern significantly.
A Comparison of Some Nature-Inspired Optimization Metaheuristics Applied in Biomedical Image Registration
Authors: Bejinariu Silviu , Costin Hariton 
Published: March 2019

Computational Intelligence Re-meets Medical Image Processing

Analysis of Machine Learning Algorithms for Diagnosis of Diffuse Lung Diseases

Background In the last decades, new optimization methods based on the nature's intelligence were developed. These metaheuristics can find a nearly optimal solution faster than other traditional algorithms even for high-dimensional optimization problems. All these algorithms have a similar structure, the difference being made by the strategies used during the evolutionary process.
Objectives A set of three nature-inspired algorithms, including Cuckoo Search algorithm (CSA), Particle Swarm Optimization (PSO), and Multi-Swarm Optimization (MSO), are compared in terms of strategies used in the evolutionary process and also of the results obtained in case of particular optimization problems.
Methods The three algorithms were applied for biomedical image registration (IR) and compared in terms of performances. The expected geometric transform has seven parameters and is composed of rotation against a point in the image, scaling on both axis with different factors, and translation.
Results The evaluation consisted of 25 runs of each IR procedure and revealed that (1) PSO offers the most precise solutions; (2) CSA and MSO are more stable in the sense that their solutions are less scattered; and (3) MSO and PSO have a higher convergence speed.
Conclusions The evaluation of PSO, MSO, and CSA was made for multimodal IR problems. It is possible that for other optimization problems and also for other settings of the optimization algorithms, the results can be different. Therefore, the nature-inspired algorithms demonstrated their efficacy for this class of optimization problems.
Entanglement distribution over a 96-km-long submarine optical fiber
Authors: Wengerowsky Sören , Joshi Siddarth Koduru , Steinlechner Fabian , Zichi Julien R. , Dobrovolskiy Sergiy M. , van der Molen René , Los Johannes W. N. , Zwiller Val , Versteegh Marijn A. M. , Mura Alberto , Calonico Davide , Inguscio Massimo , Hübel Hannes , Bo Liu , Scheidl Thomas , Zeilinger Anton , Xuereb André , Ursin Rupert 
Published: March 2019

Significance
Entanglement, the existence of correlations in distant systems stronger than those allowed by classical physics, is one of the most astonishing features of quantum physics. By distributing entangled photon pairs over a 96-km-long submarine fiber, which is part of existing infrastructure carrying internet traffic, we demonstrate that polarization entanglement-based quantum key distribution (QKD) can be implemented in real-world scenarios. QKD facilitates secure communication links between two parties, whereby the security is guaranteed by the basic property of quantum mechanics that the quantum state of a photon cannot be duplicated.
Feather pecking in laying hens: why they do it, and welfare implications.
Authors: Nicol C. J. 
Published: March 2019

Abstract

Severe feather pecking in laying hens is a significant welfare problem, causing pain, increased susceptibility to infection and an increased risk of premature death. Severe feather pecking is strongly related to absent, inadequate or insufficient foraging opportunities or to dietary deficiencies. Management practices that acknowledge the importance of foraging and dietary factors have been shown to be protective against feather pecking in commercial flocks. Further progress in prevention and control will depend on a greater understanding of the causal basis of feather pecking, and differences in individual bird propensity to peck.
Fixed Costs and Recreation Value
Authors: English Eric , Herriges Joseph A , Lupi Frank , McConnell Kenneth , von Haefen Roger H 
Published: March 2019

AbstractWelfare measures from travel cost models net out variable costs such as travel expenses specific to each trip. Costs that are fixed in the short run, such as expenses for equipment that is used over multiple trips, are typically ignored and implicitly netted out. The resulting net value of recreation trips, or consumer surplus, is appropriate for long‐run analysis when consumers can fully adjust their expenditures. However, in cases where some costs are difficult to adjust in the short run, such as when boat owners do not sell their boats in response to the transient effects of an oil spill, traditional consumer surplus measures underestimate the total welfare change. We explain this underestimation and show how to correct for it by adjusting traditional consumer surplus estimates upward. We illustrate our procedure using a model of recreational boating developed to assess damages from the Deepwater Horizon oil spill. In that case, accounting for boating fixed costs resulted in a 50% increase in estimated value relative to estimates of consumer surplus alone.
Molecular Alterations in Pulmonary Adenocarcinoma of African Americans
Authors: Rodriguez Erika F , Jones Robert , Morris C Paul , Ettinger David , Chowsilpa Sayanan , Maleki Zahra 
Published: March 2019

ABSTRACT

Objectives
Identify molecular alterations in pulmonary adenocarcinoma (ADC) in African American (AA) patients diagnosed on cytology specimens.

Methods
After institutional review board approval, we searched our database from 2013 to 2017 for AA patients with a diagnosis of pulmonary ADC. Molecular and clinical data were reviewed. White patients also diagnosed with pulmonary ADC on cytology samples formed a control group.

Results
A total of 113 patients were identified. Mean age was 63.4 years. Molecular tests were available for 91 patients. Mutations were identified in 53 (58.2%) cases. The most common mutations were EGFR (n = 19 cases, 36%) and KRAS (n = 24 cases, 45%). When compared with whites, AA patients were diagnosed at higher stages (P = .045) and demonstrated shorter overall survival (17 vs 47 months, P = .0150). No differences were noted regarding distribution of molecular alterations.

Conclusion
AA patients have similar molecular alterations in ADCs as their white counterparts. However, they have worse outcomes.
Minimal Clinically Important Difference of the Standardized Cosmesis and Health Nasal Outcomes Survey
Authors: Kandathil Cherian K , Saltychev Mikhail , Abdelwahab Mohamed , Spataro Emily A , Moubayed Sami P , Most Sam P 
Published: March 2019

Abstract

Background
The minimal clinically important difference (MCID) for the Standardized Cosmesis and Health Nasal Outcomes Survey (SCHNOS) has not been determined.

Objectives
The authors sought to define the MCID for both domains of the SCHNOS questionnaire.

Methods
This prospective cohort study included patients who underwent functional, cosmetic, or combined rhinoplasty operation from June 2017 to June 2018 at a tertiary referral center. The average preoperative, postoperative, and change in scores were calculated for the nasal obstruction symptom evaluation scale (NOSE) and SCHNOS. Anchor-based MCIDs were estimated for both SCHNOS subscales to define change in obstruction and cosmesis perceived after the rhinoplasty.

Results
Eighty-seven patients (69% women, 31% males) with a mean age (standard deviation [SD]) of 38 years (14.7) at the time of surgery were included. The mean postoperative follow-up period (SD) was 145 days (117). The mean preoperative score (SD) for the NOSE was 52 (32), SCHNOS for nasal obstruction (SCHNOS-O) score was 55 (33), and SCHNOS for nasal cosmesis (SCHNOS-C) score was 50 (26) points. Postoperatively, the NOSE score was 23 (22), SCHNOS-O score was 24 (23), and SCHNOS-C score was 13 (18) points. The mean change in scores (SD) for NOSE, SCHNOS-O, and SCHNOS-C was −29 (37), −31 (38), and −37 (28), respectively. The calculated MCID for SCHNOS-O was 26 (16) and for SCHNOS-C was 22 (15) points. The MCID for NOSE was 24 (13) points. A sensitivity test for the patients with a follow-up ≥3 months showed only slightly different MCID estimates: 28 (17) for SCHNOS-O, 18 (13) for SCHNOS-C, and 24 (15) points for NOSE.

Conclusions
For the obstruction domain SCHNOS-O, the MCID was 28 points. For the cosmetic domain SCHNOS-C, the MCID was 18 points.