bluuebunny/crossref_metadata_2025_split huggingface dataset:
Der Treitz-Muskel
Authors: Köln Magga Corts 
Published: October 2018

SummaryDer Musculus suspensorius duodeni (Treitz-Muskel) fixiert die Biegung des Zwölffingerdarms. Er kann Passagestörungen am duodenojejunalen Übergang auslösen oder (seltener) die arterielle Versorgung des Mitteldarms beeinträchtigen. Ist er kaum oder nicht ausgebildet, nennt man die vorhandene bandartige Struktur Ligamentum suspensorium duodeni (Treitz-Band).
Pflasterstein und Fahrradschlauch
Authors: Schmid HP Eva C. 
Published: October 2018

SummaryMorbus Crohn und Colitits ulcerosa sind die häufigsten chronisch-entzündlichen Darmerkrankungen (CED) in Deutschland. Die Krankheiten haben viele Gemeinsamkeiten, unterscheiden sich aber auch hinsichtlich einiger Aspekte.
Flut der Mediatoren
Authors: Hufen-Kemper Wulf 
Published: October 2018

SummaryDas Mastzellaktivierungssyndrom (MCAS) oder Mastzellmediatorsyndrom ist durch eine gesteigerte Aktivität und Vermehrung von Mastzellen geprägt, die unkontrolliert Entzündungsmediatoren wie Zytokine ausschütten. Aufgrund der unspezifischen Klinik mit schubweisen Entzündungsphasen einschließlich Darm-, Haut- und Leistungsstörungen ist die Erkrankung schwer zu identifizieren und bleibt häufig lange unentdeckt. Anamnese und vor allem Laborparameter ermöglichen eine diagnostische Abgrenzung und eröffnen Therapieoptionen unter anderem zur immunologischen Regulation und Histaminreduzierung.
Steuerliche Abzugsfähigkeit eines Arbeitszimmers
Authors: Dornbusch Hans-Ludwig 
Published: October 2018

SummaryEin Arbeitszimmer zu Hause, welches so gut wie ausschließlich beruflich genutzt wird, kann zumindest teilweise steuerlich abgesetzt werden. Das gilt unter gewissen Bedingungen und nur, wenn die Praxis keinen geeigneten Raum bietet. Auch beruflich bedingte Einrichtungsgegenstände in den privaten vier Wänden können abgesetzt werden. Bei Kosten, die für das gesamte Zuhause anfallen, kann der Anteil, der auf das Arbeitszimmer fällt, geltend gemacht werden.
Schießpulver und Abführmittel
Authors: Ell-Beiser Helga 
Published: October 2018

SummaryFrüher verwendete man den Faulbaum als Bestandteil von Schießpulver. Der Baum wird aber auch als Heilmittel eingesetzt. Die Rinde des Gewöhnlichen Faulbaums als auch des Amerikanischen Faulbaums zählt zu den Anthranoiddrogen und wirkt laxierend, hydragog und antiresorptiv.
Peroral endoscopic myotomy (POEM) is effective in treatment of noncardiac chest pain caused by hypercontractile esophageal motility disorders: results of the POEM-HYPE-Study
Authors: Albers David , Frieling Thomas , Dakkak Dani , Kuhlbusch-Zicklam Rita , Töx Ulrich , Gittinger Mathis , Schumacher Brigitte 
Published: October 2018

Abstract
Background Noncardiac chest pain (NCCP) is recurrent angina pectoris-like pain without evidence of coronary heart disease in conventional diagnostic evaluation. In gastroenterology, managing of patients with NCCP is ambiguous to detect gastroesophageal reflux and hypercontractile esophageal motility disorders. Recently, peroral endoscopic myotomy (POEM) was established as treatment option in achalasia. However, limited data exist on the effectivity of POEM in NCCP with hypercontractile esophageal motility disorders.
Material and methods In this prospective study (POEM-HYPE), we evaluated 14 patients with NCCP and hypercontractile esophageal motility disorders (type III achalasia, n = 7; hypercontractile esophagus, n = 6; distal esophageal spasm, n = 1). All patients underwent standardized diagnostic work-up including esophagogastroduodenoscopy with esophageal biopsies, high-resolution esophageal manometry, and combined intraluminal impedance and pH testing before and 3 weeks after POEM. A standardized symptom questionnaire was disposed before POEM, 3 weeks after, and every 6 months after the POEM.
Results After POEM, 12 patients showed significant symptom relief (pre-Eckardt score: 7.78 ± 1.47, 3 weeks post: 1.64 ± 1.44, 6 months: 2.0 ± 1.84 and 1.86 ± 1.89 after 15.0 ± 10.0 months post-intervention). High-resolution manometry showed significant reduction in integrated relaxation pressure (pre-POEM: 24.74 ± 18.9 mm Hg, post-POEM: 13.8 ± 16.5 mm Hg) and distal contractile integral (pre-POEM: 2880 ± 3700 mmHg*s*cm, post-POEM: 1109 ± 1042 mmHg*s*cm). One lesion of the submucosal tunnel occurred as a moderate adverse event and was handled endoscopically. The long-term clinical success rate was 85.7 %. No severe gastroesophageal reflux occurred after interventions. Two patients required secondary therapy with injection of botulinum toxin in the tubular esophagus and balloon dilation.
Conclusion The results suggest that POEM is an effective and safe therapeutic option for patients with NCCP and hypercontractile esophageal motility disorders.
Endoscopic full-thickness resection in the colorectum: a single-center case series evaluating indication, efficacy and safety
Authors: Haasnoot Krijn , van der Spek Bas , Meischl Christof , Heine Dimitri 
Published: October 2018

Abstract
Background and study aims Endoscopic full-thickness resection (eFTR) allows en-bloc and transmural resection of colorectal lesions for which other advanced endoscopic techniques are unsuitable. We present our experience with a novel “clip first, cut later” eFTR-device and evaluate its indications, efficacy and safety.
Patients and methods From July 2015 through October 2017, 51 eFTR-procedures were performed in 48 patients. Technical success and R0-resection rates were prospectively recorded and retrospectively analyzed.
Results Indications for eFTR were non-lifting adenoma (n = 19), primary resection of malignant lesion (n = 2), resection of scar tissue after incomplete endoscopic resection of low-risk T1 colorectal carcinoma (n = 26), adenoma involving a diverticulum (n = 2) and neuroendocrine tumor (n = 2). Two lesions were treated by combining endoscopic mucosal resection and eFTR. Technical success was achieved in 45 of 51 procedures (88 %). Histopathology confirmed full-thickness resection in 43 of 50 specimens (86 %) and radical resection (R0) in 40 procedures (80 %). eFTR-specimens, obtained for indeterminate previous T1 colorectal carcinoma resection, were free of residual carcinoma in 25 of 26 cases (96 %). In six patients (13 %) a total of eight adverse events occurred within 30 days after eFTR. One perforation occurred, which was corrected endoscopically. No emergency surgery was necessary.
Conclusion In this study eFTR appears to be safe and effective for the resection of colorectal lesions. Technical success, R0-resection and major adverse events rate were reasonable and comparable with eFTR data reported elsewhere. Mean specimen diameter (23 mm) limits its use to relatively small lesions. A clinical algorithm for eFTR case selection is proposed. eFTR ensured local radical excision where other endoscopic techniques did not suffice and reduced the need for surgery in selected cases.
Bauchhirn unter Stress
Authors: Hinteregger-Männel Jessica 
Published: October 2018

SummaryUm Verdauungsvorgänge zu kontrollieren und zu regulieren, arbeiten das enterische Nervensystem (ENS) und das zentrale Nervensystem (ZNS) zusammen. Bei Reizdarmpatienten lässt sich häufig ein erhöhter Sympathikotonus nachweisen, der die Magen-Darm-Tätigkeit reduziert. Einen entscheidenden Einfluss auf die neuronale Steuerung der Verdauung nehmen auch Bakterien im Darm, die über Neurotransmitter mit dem ZNS kommunizieren können.
Eine Schamanin kämpft
Authors: Lauerer Matthias 
Published: October 2018

SummarySie bewohnen die chilenische Wüste und müssen sich heute gegen die Gier der Neuzeit wehren: Die Atacameños. Für die Kultur und Natur hat es einschneidende Konsequenzen, wenn immer mehr Lithium abgebaut und geothermale Energie gewonnen wird. Eine Schamanin setzt sich gegen den Raubbau ein.
Zur Leistungsvalidierung neuropsychologischer Testergebnisse – eine Übersicht
Authors: Spirig Esther , Jokeit Hennric 
Published: October 2018

ZusammenfassungDer vorliegende Artikel bietet eine Übersicht zur Forschung und Praxis der Leistungsvalidierung neuropsychologischer Testergebnisse. Im Zentrum stehen dabei der Begriff der Leistungsvalidierung sowie seine Abgrenzung zum bisher verwendeten Begriff der Beschwerdenvalidierung. Zielgruppe sind mit Gutachten befasste Neurologen, Psychiater, Psychologen, Juristen und Rechtsanwender. Konzipiert ist der Artikel als ein Leitfaden zur Interpretation von Minderleistungen insbesondere im neuropsychologischen und verhaltensneurologischen Untersuchungskontext. Die Diskussion zur Leistungsvalidierung von Testergebnissen und ihrer psychologischen, medizinischen, rechtlichen und ökonomischen Bedeutung soll die Leserschaft für mögliche Fehlerquellen bei der Interpretation von Minderleistungen sensibilisieren und dadurch die reflektierte Anwendung von Leistungsvalidierungsverfahren sowie eine gut fundierte Interpretation von Minderleistungen fördern.
Enhanced Contouring of Local Flaps
Authors: Sclafani Anthony , Lin Jiahui 
Published: October 2018

AbstractScars and flaps represent a disruption of the normal skin contour, shape, and texture. Successful reconstruction of facial defects with local flaps requires prior planning to choose the correct reconstructive method. However, thorough preoperative planning should include consideration of adjunctive procedures to improve expected postoperative results as well as potential procedures to improve less-than-ideal results. Approaching facial reconstruction holistically allows the surgeon to soberly assess his/her reconstructive results and attain outstanding appearance.
Facial Scar Improvement Procedures
Authors: Newberry Christopher , Thomas J. , Cerrati Eric 
Published: October 2018

AbstractScars are a natural part of dermal healing following lacerations, incisions, or tissue loss. The ideal scar is narrow, flat, level with surrounding tissue, and difficult for the untrained eye to see due to color match and placement parallel to relaxed skin tension lines; however, scarring that is dyspigmented, hypertrophied, widened, contracted, or atrophic can be aesthetically displeasing or causing functional limitations. When the scar has unfavorable characteristics, scar revision is often indicated and the cosmetic surgeon must be knowledgeable of the minimally invasive as well as surgical techniques to improve aesthetics, reduced reoccurrence, or correct functional limitations.
Computed Tomography Assessment of Canal Centering Ability Using Hand and Rotary Instruments - an In Vitro Study
Authors: Arora Alka , Chaudhary Devendera , Krishan Shalu , Padda Bhupinder 
Published: October 2018

Abstract
Aim: The present in vitro study aims to evaluate canal preparation comparing centering ability of ProTaper, Mtwo, Wave One, Hand Ni-Ti K-files using Computed Tomography(CT). Materials and Methods: Sixty extracted permanent teeth were selected and decoronated at 11 mm from the apical end. Samples were randomly divided into 4 groups as ProTaper, Mtwo, Wave One, Hand Ni-Ti K-files. Teeth were scanned by CT Scanner. Sectioning was started at 1 mm from the apex up to coronal orifice. Nine levels at 1 mm each were chosen for evaluation in the Computed Tomography. The canals were prepared and a post instrumentation scan was again taken. The pre and postoperative CT images were superimposed at all nine levels. The canal centering ability was calculated. Statistical data was evaluated using One Way Analysis Of Variance test. Results: Amongst the rotary and reciprocal groups the best canal centering ability at the apical third was seen with Wave one. All the three groups behaved similarly in the middle and coronal thirds of the root canal. Conclusion: Keeping in mind the importance of apical third preparation and consistent behaviour in all directions, Wave One may be considered by far the best in the apical third.
Comparative Evaluation of Tensile Bond Strength of Nickel-Chromium Alloy to Dental Enamel Using Different Resin Cements – An In Vitro Study.
Authors: Kumar Manjit , Gupta Abhishek , Chabhra Vandana ,   Deepika
Published: October 2018

Abstract
Aim: The aim of this study was to evaluate and compare the tensile bond strength of nickel-chromium alloy to dental enamel by using four different resin cements. Materials and Methods: 40 extracted central incisor teeth embedded in acrylic blocks were flattened not to expose dentin. Wax rectangular blocks of 5 mm length, 5 mm width and 1 mm height with a loop were invested and casted using Nickel-Chromium alloy by conventional induction casting method and sandblasted. Then casted rectangular blocks and 40 tooth embedded acrylic samples were divided into four groups (10 each) and cemented to tooth enamel following manufacturer's instructions as; GroupAcemented using RelyX U200, Group B cemented using Smartcem 2, Group C cemented using Multilink Speed and Group D cemented using Multilink N and then stored in artificial saliva for 24 hours. The direct pull tensile test was carried out on Universal Testing Machine at cross head speed of 0.5mm/min. Results: One way ANOVA showed a highly statistically significant (p<.01) difference between all the four resin cements. Post Hoc Tests- Multiple comparisons showed highly statistically significant (p< 0.01) difference between RelyX U200: Multilink N, Smartcem 2: Multilink Speed, Smartcem 2: Multilink N, Multilink Speed: Multilink N. Difference between RelyX U200 : Smartcem 2 and RelyX U200 : Multilink Speed was statistically significant(p< 0.05). Conclusion: Self etch resin cement (Multilink N) showed maximum mean tensile bond strength as compared to self-adhesive resin cements (Smartcem 2, RelyX U200 and Multilink Speed). Clinically the greatest advantage of self-adhesive cements is the easy and fast application technique. But this time saving technique is not as effective as self-etch resin luting agents. The presumed benefit of saving time with self-adhesive luting agents may only be realized at the expense of compromising bond strength.
Focal Cemento-Osseous Dysplasia of Lower Jaw in an Elderly Woman: Clinicopathological Features and Management in a Case Report
Authors: Kapoor Swati , Singh Gurnam , Kumar Dinesh , Bajaj Puneet , Bhardwaj Alka 
Published: October 2018

AbstractFocal cemento-osseous dysplasia is a benign fibroosseous lesion that can be seen in dentulous and edentulous patients mainly in middle aged women. Although it is asymptomatic condition associated with vital teeth and needs no treatment but symptomatic patients require surgical debridement and sequestrectomy. We present a case report of symptomatic focal cemento-osseous dysplasia which requires surgical intervention.
Correction of the Lower Face and Neck
Authors: Frisenda Julia , Nassif Paul 
Published: October 2018

AbstractRejuvenation of the lower face and neck strives to reverse signs of aging while optimizing the patient's natural anatomy. Common features of an aesthetically pleasing lower face include a well-defined and appropriately balanced mandible and an acute cervicomental angle. Correction of the aging lower face and neck is accomplished through multiple surgical interventions, performed either alone or in combination. Determination of appropriate procedures is based on individual anatomic pathology. Intimate knowledge of facial anatomy and the complexity of the aging process is paramount to achieve a natural and aesthetic result. Thorough patient evaluation and counseling should precede any intervention. Specifically, the surgeon should be cognizant of the patient's skeletal structure, soft tissue distribution, muscular anatomy, and skin quality. Appropriate postoperative care and management of complications are vital to success.
New Device for the Treatment of Functional Ischemic Mitral Regurgitation: Proof of Concept in an In Vitro Model
Authors: Stock Sina , Scharfschwerdt Michael , Warnecke Rebecca Janina , Richardt Doreen , Tsvelodub Stanislav , Sievers Hans-Hinrich 
Published: October 2018

Background Optimal surgical treatment of functional ischemic mitral regurgitation (FIMR) is still controversy. Due to the underlying pathophysiology, stand-alone ring annuloplasty is assumed with a high recurrence rate of mitral regurgitation, thus additional subvalvular repair techniques might improve the results. This in vitro study introduces a new device for subvalvular mitral valve repair.
Methods We developed a new device for subvalvular mitral valve repair, consisting of two frames for papillary muscle (PM) attachment, which are connected with two holding bars serving for fixation of the device on an annuloplasty ring. In the first experimental run, porcine mitral valves including the chordae tendineae and PMs were fixated on a holding device, consisting of a holding ring simulating mitral annulus dilation and height-adjustable frames for PM attachment simulating leaflet tethering. In vitro regurgitant volume was determined in a pulse duplicator. Afterward, the frames for PM attachment were replaced by our newly developed device and the measurements were repeated.
Results In the model simulating FIMR, the regurgitant volume was 44.3 ± 12.38 mL/stroke. After subvalvular reconstruction with our new device, the regurgitant volume was significantly reduced to 33.1 ± 11.68 mL/stroke (p = 0.009).
Conclusion In this specific in vitro model, our new device for subvalvular mitral valve reconstruction led to a significant reduction of the regurgitant volume, thus representing a promising technique to potentially improve the results of mitral reconstruction in ischemic functional mitral valve regurgitation. Additional studies are required to further investigate and improve our device.
mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level
Authors: Zeng Hao , Lu Bo , Zamponi Raffaella , Yang Zinger , Wetzel Kristie , Loureiro Joseph , Mohammadi Sina , Beibel Martin , Bergling Sebastian , Reece-Hoyes John , Russ Carsten , Roma Guglielmo , Tchorz Jan S. , Capodieci Paola , Cong Feng 
Published: October 2018

SignificanceThe Wnt/β-catenin signaling pathway plays prominent roles during embryonic development and adult tissue homeostasis by maintaining somatic stem cell functions. The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway has also been implicated in regulating stem cell functions in multiple tissue types. However, the crosstalk between these two pathways remains largely unclear. Herein, using in vitro cell lines, ex vivo organoids, and an in vivo mouse model, we made striking findings in support of a paradigm that mTORC1 signaling cell autonomously suppresses Wnt/β-catenin signaling through down-regulating the Wnt receptor FZD level to influence stem cell functions, with implications in the aging process.
Volatile loss following cooling and accretion of the Moon revealed by chromium isotopes
Authors: Sossi Paolo A. , Moynier Frédéric , van Zuilen Kirsten 
Published: October 2018

Significance
With the exception of volatile elements, which are strongly depleted and isotopically fractionated, the Moon has chemical and isotopic signatures that are indistinguishable from Earth’s mantle. Reconciliation of these properties with Moon formation in a high-energy giant impact invokes evaporative loss of volatile elements, but at conditions that are poorly known. Chromium isotopic fractionation is sensitive to temperature variations and liquid–gas equilibration during evaporation. We measure an isotopic difference between Earth’s mantle and the Moon, consistent with the loss of a Cr-bearing, oxidized vapor phase in equilibrium with the proto-Moon. Temperatures of vapor loss required are much lower than predicted by recent models, implying that volatile elements were removed from the Moon following cooling rather than during a giant impact.
Long-term dietary supplementation with the green tea cultivar Sunrouge prevents age-related cognitive decline in the senescence-accelerated mouse Prone8
Authors: Wasai Masafumi , Nonaka Haruna , Murata Motoki , Kitamura Ryo , Sato Yuka , Tachibana Hirofumi 
Published: October 2018

ABSTRACT
A majority of the potential health benefits of green tea, including the potential to prevent cognitive decline, have been attributed to epigallocatechin gallate (EGCG). Sunrouge is a green tea cultivar that contains EGCG and several other bioactive components such as quercetin, myricetin, cyanidin and delphinidin. We compared the effects of Sunrouge and Yabukita, the most popular Japanese green tea cultivar, on cognitive function in the senescence-accelerated mouse Prone8. These mice were fed an experimental diet containing Sunrouge extract (SRE) or Yabukita extract (YBE). SRE feeding significantly prevented cognitive decline, whereas YBE feeding had little effect. Moreover, SRE feeding prevented elevation of the amyloid-β42 level while improving the gene expression of neprilysin and decreasing beta-site APP-cleaving enzyme 1 in the brain. These preventive effects of SRE against cognitive decline were attributed to the characteristic composition of Sunrouge and strongly suggest that consumption of this cultivar could protect against age-related cognitive decline.
A highly stable laccase from Bacillus subtilis strain R5: gene cloning and characterization
Authors: Basheer Saadia , Rashid Naeem , Akram Muhammad Sohail , Akhtar Muhammad 
Published: October 2018

ABSTRACT
The gene encoding copper-dependent laccase from Bacillus subtilis strain R5 was cloned and expressed in Escherichia coli. Initially the recombinant protein was produced in insoluble form as inclusion bodies. Successful attempts were made to produce the recombinant protein in soluble and active form. The laccase activity of the recombinant protein was highly dependent on the presence of copper ions in the growth medium and microaerobic conditions during protein production. The purified enzyme exhibited highest activity at 55 °C and pH 7.0. The recombinant protein was highly thermostable, albeit from a mesophilic source, with a half-life of 150 min at 80 °C. Similar to temperature, the recombinant protein was stable in the presence of organic solvents and protein denaturants such as urea. Furthermore, the recombinant protein was successfully utilized for the degradation of various synthetic dyes reflecting its potential use in treatment of wastewater in textile industry.
Abbreviations: ABTS,2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid; CBB, Coomassie brilliant blue; SGZ, syringaldazine; DMP, 2,2-dimethoxy phenol.
Pressure effect at permeability and deformation of the hollow fiber membrane gas separation module
Authors: Laguntsov N I , Karaseva M D 
Published: October 2018

Abstract
In this paper, the deformation effect in the gas separation process of the hollow fiber membrane module is considered. A technique of gas permeability measurement in a commercial gas separation hollow fiber membrane module is provided. It is determined that permeability and selectivity are nonlinearly dependent on the pressure of the feed stream, this is justified by competing factors. The results of this work will allow introducing the membrane modules into hybrid gas separation units, in particular, into the drying unit of compressed gas.