bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crise de legitimação? Sobre as contradições políticas do capitalismo financeirizado
Authors: Fraser Nancy , Sousa Filho José Ivan Rodrigues de 
Published: December 2018

Democracia de fachada. Pós-democracia. Democracia moribunda. Desdemocratização. Ao multiplicarem tais termos, muitos observadores introduzem a hipótese de que estamos passando por uma “crise da democracia”. Mas o que exatamente está em crise aqui? Defendo que as atuais aperturas da democracia são melhor compreendidas como expressões, sob condições contemporâneas historicamente específicas, de uma tendência geral à crise política que é intrínseca às sociedades capitalistas. Desenvolvo essa tese em três passos. Primeiro, proponho uma explicação geral da “contradição política do capitalismo” enquanto tal, sem referência a qualquer forma histórica particular. Em seguida, reconstruo Problemas de Legitimação no Capitalismo Tardio, livro de Jürgen Habermas publicado em 1973, como uma explicação da forma que essa contradição política assumiu numa fase específica da sociedade capitalista, a saber, o capitalismo estatalmente administrado do período subsequente à Segunda Guerra Mundial. Por último, esboço uma explicação dos problemas atuais da democracia como expressões da contradição política do capitalismo em sua presente fase, a financeirizada.
[Texto original: Fraser, N. (2015). Legitimation crisis? On the political contradictions of financialized capitalism. Critical Historical Studies, 2(2), pp.157-189. DOI: https://doi.org/10.1086/683054. Tradução de José Ivan Rodrigues de Sousa Filho (Universidade Federal de Santa Catarina, CAPES), com a expressa autorização da autora (titular dos direitos autorais) e com o benefício da cuidadosa revisão de um par anônimo de pareceristas. (N. T.)]
The identification of Takin Budorcas taxicolor (Mammalia: Bovidae) through dorsal guard hair
Authors: Kamalakannan Manokaran 
Published: December 2018

The dorsal guard hairs of Takin Budorcas taxicolor was examined using the optical light and scanning electron microscopes for species identification. It is found that the dorsal guard hair of B. taxicolor is possessed a completely unique microscopic characteristic especially the medullary character-uniserial ladder structure, which differs from other species of mammals. The ‘irregular wave’ of scale patterns and ‘rippled’ scale margins of cuticular, and the ‘circular’ shape of a transverse section of hair also determines the species identity of B. taxicolor, because these characteristics are infrequent in other species of mammals. The micro-photographs and characters of hairs are presented here can be used in the forensic science, as an appropriate reference for species identification of B. taxicolor.
Odonata (Insecta) diversity of Kuldiha Wildlife Sanctuary and its adjoining areas, Odisha, eastern India
Authors: Debata Subrat , Swain Kedar Kumar 
Published: December 2018

A study was carried out to assess the Odonata fauna of Kuldiha Wildlife Sanctuary, Odisha, eastern India from November 2012 to October 2013. During the study a total of 54 species of odonates including 37 species of dragonflies (Anisoptera) and 17 species of damselflies (Zygoptera) were recorded. Among the dragonflies, the family Libellulidae was well represented with 30 species whereas among the damselflies, Coenagrionidae was well represented with seven species. Overall, the odonate fauna of Kuldiha Wildlife Sanctuary accounted for 49.09% of the odonate species known from Odisha and 10.73% of India. Therefore, further long-term studies on these lesser-known insect fauna in Kuldiha Wildlife Sanctuary will be useful in understanding their status over time.
An updated list of Odonata of southwestern Bangladesh
Authors: Tuhin M. Sajjad Hossain , Khan M. Kawsar 
Published: December 2018

An odonate survey was conducted throughout the southwestern region of Bangladesh, concentrating on eight districts and the Sundarban, from August 2014 to August 2016. A total of 50 species under 30 genera belonging to six families was recorded during the study period. Among these, 31 species belonged to Anisoptera and 19 to Zygoptera suborders. Libellulidae and Coenagrionidae were the most dominant anisopteran and zygopteran families with 28 and 17 species, respectively. One Zygoptera species Mortonagrion varalli was newly added to the odonate fauna of Bangladesh.
First record of Leptogenys hysterica Forel, 1900 (Hymenoptera: Formicidae: Ponerinae) from Pakistan
Authors: Rasheed Muhammad Tariq , Bodlah Imran , Fareen Ammara Gull e , Huang Xiaolei 
Published: December 2018

Leptogenys Roger, 1861 is one of the speciose genera in the subfamily Ponerinae. There were no previous records of any species of this genus from Pakistan, though many such species were reported from various parts of the world, including its neighbouring countries. In the current study, one species of this genus, L. hysterica Forel, 1900, is reported for the first time from Pakistan based on individuals of the worker caste. Description, differential diagnosis, morphometrics, and illustrations of the species are provided along with notes on its distribution. This study will provide a baseline for further exploration of this genus in Pakistan.
Amphibians of the Dibang River Basin, Arunachal Pradesh: an annotated checklist with distribution records
Authors: Roy Jayanta K. , Begum Ramie H. , Ahmed M. Firoz 
Published: December 2018

The present study across the Dibang River Basin is being presented as an annotated checklist from Arunachal Pradesh. A systematic survey was conducted during 2014–2017 by visual encounter surveys, as well as opportunistic records across the basin. Thirty-eight species of amphibians belonging to 17 genera in six families were recorded. Five new distribution records for Arunachal Pradesh, and one genus Oreolalax was recorded for the first time from India. Further, a rare report on Theloderma moloch and Rhacophorus tuberculatus from northeastern India provided significant information on species microhabitat and updated the amphibian distribution records from Arunachal Pradesh.
ZFP148 (Zinc-Finger Protein 148) Binds Cooperatively With NF-1 (Nuclear Factor 1) to Inhibit Smooth Muscle Marker Gene Expression During Abdominal Aortic Aneurysm Formation
Authors: Salmon Morgan , Schaheen Basil , Spinosa Michael , Montgomery William , Pope Nicolas H. , Davis John P. , Johnston William F. , Sharma Ashish K. , Owens Gary K. , Merchant Juanita L. , Zehner Zendra E. , Upchurch Gilbert R. , Ailawadi Gorav 
Published: December 2018

Objective—
The goal of this study was to determine the role of ZFP148 (zinc-finger protein 148) in aneurysm formation.

Approach and Results—
ZFP148 mRNA expression increased at day 3, 7, 14, 21, and 28 after during abdominal aortic aneurysm formation in C57BL/6 mice. Loss of ZFP148 conferred abdominal aortic aneurysm protection using ERTCre+ ZFP148 flx/flx mice. In a third set of experiments, smooth muscle-specific loss of ZFP148 alleles resulted in progressively greater protection using novel transgenic mice (MYH [myosin heavy chain 11] Cre+ flx/flx, flx/wt, and wt/wt). Elastin degradation, LGAL3, and neutrophil staining were significantly attenuated, while α-actin staining was increased in ZFP148 knockout mice. Results were verified in total cell ZFP148 and smooth muscle-specific knockout mice using an angiotensin II model. ZFP148 smooth muscle-specific conditional mice demonstrated increased proliferation and ZFP148 was shown to bind to the p21 promoter during abdominal aortic aneurysm formation. ZFP148 smooth muscle-specific conditional knockout mice also demonstrated decreased apoptosis as measured by decreased cleaved caspase-3 staining. ZFP148 bound smooth muscle marker genes via chromatin immunoprecipitation analysis mediated by NF-1 (neurofibromin 1) promote histone H3K4 deacetylation via histone deacetylase 5. Transient transfections and chromatin immunoprecipitation analyses demonstrated that NF-1 was required for ZFP148 protein binding to smooth muscle marker genes promoters during aneurysm formation. Elimination of NF-1 using shRNA approaches demonstrated that NF-1 is required for binding and elimination of NF-1 increased BRG1 recruitment, the ATPase subunit of the SWI/SWF complex, and increased histone acetylation.

Conclusions—
ZFP148 plays a critical role in multiple murine models of aneurysm formation. These results suggest that ZFP148 is important in the regulation of proliferation, smooth muscle gene downregulation, and apoptosis in aneurysm development.
Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface
Authors: Nechipurenko Dmitry Y. , Receveur Nicolas , Yakimenko Alena O. , Shepelyuk Taisiya O. , Yakusheva Alexandra A. , Kerimov Roman R. , Obydennyy Sergei I. , Eckly Anita , Léon Catherine , Gachet Christian , Grishchuk Ekaterina L. , Ataullakhanov Fazoil I. , Mangin Pierre H. , Panteleev Mikhail A. 
Published: December 2018

Objective—
After activation at the site of vascular injury, platelets differentiate into 2 subpopulations, exhibiting either proaggregatory or procoagulant phenotype. Although the functional role of proaggregatory platelets is well established, the physiological significance of procoagulant platelets, the dynamics of their formation, and spatial distribution in thrombus remain elusive.

Approach and Results—

Using transmission electron microscopy and fluorescence microscopy of arterial thrombi formed in vivo after ferric chloride–induced injury of carotid artery or mechanical injury of abdominal aorta in mice, we demonstrate that procoagulant platelets are located at the periphery of the formed thrombi. Real-time cell tracking during thrombus formation ex vivo revealed that procoagulant platelets originate from different locations within the thrombus and subsequently translocate towards its periphery. Such redistribution of procoagulant platelets was followed by generation of fibrin at thrombus surface. Using in silico model, we show that the outward translocation of procoagulant platelets can be driven by the contraction of the forming thrombi, which mechanically expels these nonaggregating cells to thrombus periphery. In line with the suggested mechanism, procoagulant platelets failed to translocate and remained inside the thrombi formed ex vivo in blood derived from nonmuscle myosin (
MYH9
)-deficient mice. Ring-like distribution of procoagulant platelets and fibrin around the thrombus observed with blood of humans and wild-type mice was not present in thrombi of
MYH9
-knockout mice, confirming a major role of thrombus contraction in this phenomenon.

Conclusions—
Contraction of arterial thrombus is responsible for the mechanical extrusion of procoagulant platelets to its periphery, leading to heterogeneous structure of thrombus exterior.
Gene-Based Elevated Triglycerides and Type 2 Diabetes Mellitus Risk in the Women’s Genome Health Study
Authors: Ahmad Shafqat , Mora Samia , Ridker Paul M , Hu Frank B. , Chasman Daniel I. 
Published: December 2018

Objective—
Higher triglyceride (TG) is a risk factor for incident type 2 diabetes mellitus (T2DM), but paradoxically, genetic susceptibility for higher TG has been associated with lower T2DM risk. There is also evidence that the genetic association may be modified by baseline TG. Whether such associations can be replicated and the interaction is selective for certain TG-rich lipoprotein particles remains to be explored.

Approach and Results—

Cox regression involving TG, TG-rich lipoprotein particles, and genetic determinants of TG was performed among 15 813 participants with baseline fasting status in the WGHS (Women’s Genome Health Study), including 1453 T2DM incident cases during a mean 18.6 (SD=5.3) years of follow-up. A weighted, 40–single-nucleotide polymorphism TG genetic risk score was inversely associated with incident T2DM (hazard ratio [95% CI], 0.66 [0.58–0.75]/10-TG risk alleles;
P
<0.0001) with adjustment for baseline body mass index, HDL (high-density lipoprotein) cholesterol, and TG. TG-associated risk was higher among individuals in the low compared with the high 40–single-nucleotide polymorphism TG genetic risk score tertile (hazard ratio [95% CI], 1.98 [1.83–2.14] versus 1.68 [1.58–1.80] per mmol/L;
P
interaction
=0.0007). In TG-adjusted analysis, large and medium but not small TG-rich lipoprotein particles were associated with higher T2DM incidence for successively lower 40–single-nucleotide polymorphism TG genetic risk score tertiles,
P
interaction
=0.013, 0.012, and 0.620 across tertiles, respectively.

Conclusions—
Our results confirm the previous observations of the paradoxical associations of TG with T2DM while focusing attention on the larger TG-rich lipoprotein particle subfractions, suggesting their importance in clinical profiling of T2DM risk.
Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community
Authors: Shah Ravi V. , Hwang Shih-Jen , Yeri Ashish , Tanriverdi Kahraman , Pico Alexander R. , Yao Chen , Murthy Venkatesh , Ho Jennifer , Vitseva Olga , Demarco Danielle , Shah Sajani , Iafrati Mark D. , Levy Daniel , Freedman Jane E. 
Published: December 2018

Objective—
Mechanisms of early and late improvements in cardiovascular risk after bariatric surgery and applicability to larger, at-risk populations remain unclear. We aimed to identify proteins altered after bariatric surgery and their relations to metabolic syndrome and diabetes mellitus.

Approach and Results—

We identified 19 proteins altered in 32 nonfasting plasma samples from a study of patients undergoing bariatric surgery who were evaluated preoperatively (visit 1) versus both early (visit 2; ≈3 months) and late (visit 3; ≈12 months) postoperative follow-up using predefined protein panels (Olink). Using in silico methods and publicly available gene expression repositories, we found that genes encoding 8 out of 19 proteins had highest expression in liver relative to other assayed tissues, with the top biological and disease processes, including major obesity-related vascular diseases. Of 19 candidate proteins in the surgical cohort, 6 were previously measured in >3000 FHS (Framingham Heart Study) participants (IGFBP [insulin-like growth factor binding protein]-1, IGFBP-2, P-selectin, CD163, LDL (low-density lipoprotein)-receptor, and PAI [plasminogen activator inhibitor]-1). A higher concentration of IGFBP-2 at baseline was associated with a lower risk of incident metabolic syndrome (odds ratio per log-normal unit, 0.45; 95% CI, 0.32–0.64;
P
=7.7×10
-6
) and diabetes mellitus (odds ratio, 0.63; 95% CI, 0.49–0.79;
P
=0.0001) after multivariable adjustment.

Conclusions—
Using a directed protein quantification platform (Olink), we identified known and novel proteins altered after surgical weight loss, including IGFBP-2. Future efforts in well-defined obesity intervention settings may further define and validate novel targets for the prevention of vascular disease in obesity.
Effectiveness and Safety of Oral Anticoagulants Among Nonvalvular Atrial Fibrillation Patients
Authors: Lip Gregory Y.H. , Keshishian Allison , Li Xiaoyan , Hamilton Melissa , Masseria Cristina , Gupta Kiran , Luo Xuemei , Mardekian Jack , Friend Keith , Nadkarni Anagha , Pan Xianying , Baser Onur , Deitelzweig Steven 
Published: December 2018

Background and Purpose—
This ARISTOPHANES study (Anticoagulants for Reduction in Stroke: Observational Pooled Analysis on Health Outcomes and Experience of Patients) used multiple data sources to compare stroke/systemic embolism (SE) and major bleeding (MB) among a large number of nonvalvular atrial fibrillation patients on non–vitamin K antagonist oral anticoagulants (NOACs) or warfarin.

Methods—
A retrospective observational study of nonvalvular atrial fibrillation patients initiating apixaban, dabigatran, rivaroxaban, or warfarin from January 1, 2013, to September 30, 2015, was conducted pooling Centers for Medicare and Medicaid Services Medicare data and 4 US commercial claims databases. After 1:1 NOAC-warfarin and NOAC-NOAC propensity score matching in each database, the resulting patient records were pooled. Cox models were used to evaluate the risk of stroke/SE and MB across matched cohorts.

Results—
A total of 434 046 patients were included in the 6 matched cohorts: 100 977 apixaban-warfarin, 36 990 dabigatran-warfarin, 125 068 rivaroxaban-warfarin, 37 314 apixaban-dabigatran, 107 236 apixaban-rivaroxaban, and 37 693 dabigatran-rivaroxaban patient pairs. Apixaban (hazard ratio [HR], 0.64; 95% CI, 0.58–0.70), dabigatran (HR, 0.82; 95% CI, 0.71–0.95), and rivaroxaban (HR, 0.79; 95% CI, 0.73–0.85) were associated with lower rates of stroke/SE compared with warfarin. Apixaban (HR, 0.60; 95% CI, 0.56–0.63) and dabigatran (HR, 0.71; 95% CI, 0.65–0.78) had lower rates of MB, and rivaroxaban (HR, 1.06; 95% CI, 1.02–1.10) had a higher rate of MB compared with warfarin. Differences exist in rates of stroke/SE and MB across NOACs.

Conclusions—
In this largest observational study to date on NOACs and warfarin, the NOACs had lower rates of stroke/SE and variable comparative rates of MB versus warfarin. The findings from this study may help inform the discussion on benefit and risk in the shared decision-making process for stroke prevention between healthcare providers and nonvalvular atrial fibrillation patients.

Clinical Trial Registration—

URL:
https://www.clinicaltrials.gov/
. Unique identifier: NCT03087487.
Door-in-Door-Out Time at Primary Stroke Centers May Predict Outcome for Emergent Large Vessel Occlusion Patients
Authors: McTaggart Ryan A. , Moldovan Krisztina , Oliver Lori A. , Dibiasio Eleanor L. , Baird Grayson L. , Hemendinger Morgan L. , Haas Richard A. , Goyal Mayank , Wang Tracy Y. , Jayaraman Mahesh V. 
Published: December 2018

Background and Purpose—
Interfacility transfers for thrombectomy in stroke patients with emergent large vessel occlusion (ELVO) are associated with longer treatment times and worse outcomes. In this series, we examined the association between Primary Stroke Center (PSC) door-in to door-out (DIDO) times and outcomes for confirmed ELVO stroke transfers and factors that may modify the interaction.

Methods—
We retrospectively identified 160 patients transferred to a single Comprehensive Stroke Center (CSC) with anterior circulation ELVO between July 1, 2015 and May 30, 2017. We included patients with acute occlusions of the internal carotid artery or proximal middle cerebral artery (M1 or M2 segments), with a National Institutes of Health Stroke Scale score of ≥6. Workflow metrics included time from onset to recanalization, PSC DIDO, interfacility transfer time, CSC arrival to arterial puncture, and arterial puncture to recanalization. Primary outcome measure was National Institutes of Health Stroke Scale at discharge and modified Rankin Scale (mRS) score at 90 days.

Results—
The median (Q1–Q3) age and National Institutes of Health Stroke Scale of the 130 ELVO transfers analyzed was 75 (64–84) and 17 (11–22). Intravenous alteplase was administered to 64% of patients. Regarding specific workflow metrics, median (Q1–Q3) times (in minutes) were 241 (199–332) for onset to recanalization, 85 (68–111) for PSC DIDO, 26 (17–32) for interfacility transport, 21 (16–39) for CSC door to arterial puncture, and 24 (15–35) for puncture to recanalization. Median discharge National Institutes of Health Stroke Scale score was 5 (2–16), and 46 (35%) patients had a favorable outcome at 90 days. Complete reperfusion (modified Thrombolysis in Cerebral Ischemia 2c/3) modified the deleterious association of DIDO on outcome.

Conclusions—
For patients diagnosed with ELVO at a PSC who are being transferred to a CSC for thrombectomy, longer DIDO times may have a deleterious effect on outcomes and may represent the single biggest modifiable factor in onset to recanalization time. PSCs should make efforts to decrease DIDO and routine use of DIDO as a performance measure is encouraged.
Ischemia-Reperfusion Injury After Endovascular Thrombectomy for Ischemic Stroke
Authors: Gauberti Maxime , Lapergue Bertrand , Martinez de Lizarrondo Sara , Vivien Denis , Richard Sébastien , Bracard Serge , Piotin Michel , Gory Benjamin 
Published: December 2018

Background and Purpose—
In experimental models of ischemic stroke, abrupt reperfusion is associated with secondary brain damages, responsible for up to 70% of the final lesion size. Whether this remains true in humans is unknown.

Methods—
Using data from the ASTER randomized trial (Aspiration vs Stent Retriever for Successful Revascularization), we investigated the effect of complete reperfusion (defined as a modified Thrombolysis In Cerebral Infarction 3) after endovascular thrombectomy on early lesion growth as assessed by diffusion-weighted imaging at baseline and 1 day after reperfusion.

Results—

Among 381 patients included in the trial, 35 achieved complete reperfusion, benefited from both baseline and day 1 diffusion-weighted imaging, lacked significant hemorrhagic transformation, and were, therefore, included in the present study. We found that the median growth of the ischemic lesion between baseline and day 1 was only 0.9 mL after complete reperfusion, representing <4% of the mean lesion size. The actual lesion growth occurring after reperfusion is probably even smaller because this lesion growth occurred, at least in part, between baseline imaging and complete reperfusion, as demonstrated by a statistically significant positive correlation between imaging-to-reperfusion time and lesion growth (
R
2
=0.116;
P
=0.048).

Conclusions—
There is no significant lesion growth after complete reperfusion in most patients. This important discrepancy between clinical and preclinical pathophysiologies should be considered during preclinical evaluation of neuroprotective strategies.
Intracranial Carotid Artery Calcification and Effect of Endovascular Stroke Treatment
Authors: Compagne Kars C.J. , Clephas Pascal R.D. , Majoie Charles B.L.M. , Roos Yvo B.W.E.M. , Berkhemer Olvert A. , van Oostenbrugge Robert J. , van Zwam Wim H. , van Es Adriaan C.G.M. , Dippel Diederik W.J. , van der Lugt Aad , Bos Daniel ,   for the MR CLEAN Investigators
Published: December 2018

Background and Purpose—
Previous studies suggest that intracranial carotid artery calcification (ICAC) volume might influence the clinical outcome of patients after endovascular treatment (EVT) for acute ischemic stroke. Importantly, ICAC can be subtyped into a medial or intimal pattern that may differentially influence the effect of EVT in patients with acute ischemic stroke.

Methods—

All 500 patients included in the MR CLEAN (Multicenter Randomized Clinical trial of Endovascular treatment for acute ischemic stroke in the Netherlands) were evaluated. Volume (mm
3
) and location pattern (tunica intima or tunica media) of ICAC could be determined on baseline noncontrast computed tomography in 344 patients. Functional outcome at 90 days was assessed with the modified Rankin Scale. Next, we investigated the association of ICAC volume and pattern with functional outcome using adjusted ordinal logistic regression models. Effect modification by EVT was assessed with an interaction term between treatment allocation and ICAC aspect.

Results—

We found evidence for treatment effect modification by ICAC pattern (
P
interaction=0.04). Patients with predominantly medial calcification had better functional outcome with EVT than without this treatment (adjusted common odds ratio, 2.32; 95% CI, 1.23–4.39), but we observed no effect of EVT in patients with predominantly intimal calcifications (adjusted common odds ratio, 0.82; 95% CI, 0.40–1.68). We did not find an association of ICAC volume with functional outcome (adjusted common odds ratio per unit increase ICAC volume 1.01 (95% CI, 0.89–1.13). Moreover, we found no evidence for effect modification by ICAC volume (
P
interaction=0.61).

Conclusions—
The benefit of EVT in acute ischemic stroke patients with a medial calcification pattern is larger than the benefit in patients with an intimal calcification pattern.

Clinical Trial Registration—

URL:
http://www.trialregister.nl
. Unique identifier: NTR1804. URL:
http://www.isrctn.com
. Unique identifier: ISRCTN10888758.