bluuebunny/crossref_metadata_2025_split huggingface dataset:
A propensity score‐adjusted HRV analysis of social avoidance and distress in patients with panic disorders
Authors: Kim Joonbeom , Ham Jinsil , Oh Jooyoung 
Published: December 2024

AbstractPanic disorder (PD) may accompany elevated social avoidance and distress (SAD). Higher SAD in patients with PD predicts a poorer prognosis and response to treatment. As heart rate variability (HRV) reflects the self‐regulatory capacity underlying SAD, applying HRV to distinguish PD heterogeneity would be clinically beneficial in formulating personalized treatment strategies. We hypothesized that HRV would be lower in patients with PD and severe SAD (PD‐SAD group) than in those without SAD (PD group). A total of 288 patients met the eligibility criteria, with complete collection of variables of interest and HRV. The inverse probability of treatment weighting (IPTW) method was used to balance the groups for the baseline characteristics of patients. Following IPTW adjustment, the average treatment effects were computed using inverse propensity weighting with regression adjustment (IPW‐RA). All characteristics were similar in both groups after IPTW adjustment. The PD‐SAD group showed a decreased tendency in time domain parameters, including mean heart rate, SDNN, RMSSD, and pNN50 with a nonlinear domain of SD1. However, no significant intergroup differences were observed in the frequency domain. Higher SAD in PD was associated with reduced HRV, mainly in the time domain, which may be attributed to the shared neural networks between dysfunctional self‐regulation statuses, as indexed by reduced HRV. As respiratory sinus arrhythmia is mainly reflected in the frequency domain, the time domain may be more reliable for identifying heterogeneity within patients with PD, who are frequently associated with respiratory pattern abnormalities.
The formation of peat—Decreasing density with depth in UK peats
Authors: Worrall Fred , Clay Gareth D. , Heckman Katherine , Ritson Jonathan , Evans Martin , Small Julian 
Published: December 2024

AbstractIncreasing bulk density with depth in a peat profile has been seen as key to the formation of peat. Increasing bulk density with depth causing the changes in porosity and permeability of peat soils has been proposed as a mechanism to explain how waterlogged, stagnant conditions persist in peat bog soils. However, a previous study (Clay & Worrall, 2015; Soil Use & Management, 31, 77) observed, in passing, that this was not always the case, but this previous study could not test the nature of the peat bulk density profile. Thus, this present study examined 22 peat cores from 13 locations across climatic gradients of the UK, including valley fens, blanket and raised bogs, and both intact peatlands and former peat extraction sites. At none of the 13 locations was there a significant increase in dry bulk density with depth in the peat profile. The oxidation state of the organic carbon (Cox) in the peat profile showed no common pattern of change with depth. The only measured property that showed a consistent change down the peat profile among all 13 locations was an increase in the degree of unsaturation of C bonds. The change in degree of unsaturation shows a trend away from vegetation biomass composition and toward lignin‐like compositions with an average rate of change of 0.2 π‐bonds/ka. The measured pattern of bulk density between locations and types of peat shows that peat density reflects the contemporary peat environment, rather than the nature of peat formation. The bulk density profile likely reflects average water table position, as determined by topographic and land‐management factors, with peat compaction and accelerated decomposition within the aerobic zone. The presence of gas bubbles may also contribute to low bulk density at depth. The common bulk density profile found across the UK for peat ecosystems shows that peat formation is not controlled by porosity change but more specifically by water flow and hydraulic conductivity.
Longitudinal reproducibility of brain and spinal cord quantitative MRI biomarkers
Authors: Boudreau Mathieu , Karakuzu Agah , Boré Arnaud , Pinsard Basile , Zelenkovski Kiril , Alonso-Ortiz Eva , Boyle Julie , Bellec Lune , Cohen-Adad Julien 
Published: December 2024

Abstract
Quantitative MRI (qMRI) promises better specificity, accuracy, repeatability, and reproducibility relative to its clinically-used qualitative MRI counterpart. Longitudinal reproducibility is particularly important in qMRI. The goal is to reliably quantify tissue properties that may be assessed in longitudinal clinical studies throughout disease progression or during treatment. In this work, we present the initial data release of the quantitative MRI portion of the Courtois project on neural modelling (CNeuroMod), where the brain and cervical spinal cord of six participants were scanned at regular intervals over the course of several years. This first release includes 3 years of data collection and up to 10 sessions per participant using quantitative MRI imaging protocols (T1, magnetization transfer (MTR, MTsat), and diffusion). In the brain, T1MP2RAGE, fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) all exhibited high longitudinal reproducibility (intraclass correlation coefficient – ICC ≃ 1 and within-subject coefficient of variations – wCV &lt; 1%). The spinal cord cross-sectional area (CSA) computed using T2w images and T1MTsat exhibited the best longitudinal reproducibility (ICC ≃ 1 and 0.7 respectively, and wCV 2.4% and 6.9%). Results from this work show the level of longitudinal reproducibility that can be expected from qMRI protocols in the brain and spinal cord in the absence of hardware and software upgrades, and could help in the design of future longitudinal clinical studies.
Is Dewey’s Aesthetics Critical? A Reflection on the Relationship Between Artificial Intelligence and Art from a Deweyan Perspective
Authors: Fiore Andrea 
Published: December 2024

Abstract
This paper addresses the issue of the relationship between technology and art in human existence from a Deweyan perspective. The central idea is that Dewey’s aesthetics is a useful instrument for critically reflecting on that issue. Starting from the tenets of Dewey’s aesthetics, the discourse focuses on “imaginative recovery” and “inhabiting,” two key notions for interpreting and managing technology from an aesthetic perspective. The article seeks an answer to the question of whether new technology (particularly ai) is a useful tool or not in art and, ultimately, for the fulfilment of human life.
Age-stratification reveals age-specific intestinal microbiota signatures in juvenile idiopathic arthritis
Authors: Budzinski Lisa , Sempert Toni , Lietz Leonie , Maier René , Kang Gi-Ung , von Stuckrad Anne Sae Lim , Goetzke Carl Christoph , Roth Maria , Shah Aayushi , Abbas Amro , Lehman Katrin , Necke Kathleen , Bartsch Stefanie , Hoffmann Ute , Mashreghi Mir-Farzin , Biesen Robert , Kallinich Tilmann , Chang Hyun-Dong 
Published: December 2024

Abstract
Objective
Juvenile Idiopathic Arthritis (JIA) comprises diverse chronic inflammatory conditions driven by malfunction of the immune system. The intestinal microbiota is considered a crucial environmental factor correlating with chronic inflammatory diseases, and for JIA certain alterations in the microbiota have already been described.

Methods
Here, we have characterized intestinal microbiota samples from 54 JIA patients and 38 pediatric healthy controls by conventional 16S rRNA sequencing and by single-cell analysis for phenotypic features by multi-parameter microbiota flow cytometry (mMFC), which complements the population-based taxonomic profiling with the characterization of individual bacterial cells.

Results
We found age to be a crucial confounder in microbiota analyses of JIA patients. Age stratification revealed specific microbiota alterations neglected by the general comparison of JIA patients and pediatric controls.

Conclusion
Age groups presented distinct taxonomic profiles and microbiota phenotypic signatures which transitioned with age, highlighting changes in the microbiota-immune system interaction with age.
Pricing and Demand Management for Integrated Same-Day and Next-Day Delivery Systems
Authors: Banerjee Dipayan , Erera Alan L. , Toriello Alejandro 
Published: December 2024

We study a system in which a common delivery fleet provides service to both same-day delivery (SDD) and next-day delivery (NDD) orders placed by e-retail customers who are sensitive to delivery prices. We develop a model of the system and optimize with respect to two separate objectives. First, empirical research suggests that fulfilling e-retail orders ahead of promised delivery days increases a firm’s long-run market share. Motivated by this phenomenon, we optimize for customer satisfaction by maximizing the quantity of NDD orders fulfilled one day early given fixed prices. Next, we optimize for total profit; we optimize for a single SDD price, and we then set SDD prices in a two-level scheme with discounts for early-ordering customers. Our analysis relies on continuous approximation techniques to capture the interplay between NDD and SDD orders and particularly the effect one day’s operations have on the next, a novel modeling component not present in SDD-only models; a key technical result is establishing the model’s convergence to a steady state using dynamical systems theory. We derive structural insights and efficient algorithms for both objectives. In particular, we show that, under certain conditions, the total profit is a piecewise-convex function with polynomially many breakpoints that can be efficiently enumerated. In a case study set in metropolitan Denver, Colorado, approximately 10% of NDD orders can be fulfilled one day early at optimality, and profit is increased by 1% to 3% in a two-level pricing scheme versus a one-level scheme. We conduct operational simulations for validation of solutions and analysis of initial conditions. History: This paper has been accepted for the Transportation Science Special Issue on TSL Conference 2023. Funding: This work was supported by the National Science Foundation [Grant DGE-1650044]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2023.0381 .
Entscheidungsbesprechung „Google – Offenlegung“ – BGH, Beschl. v. 20. 2. 2024 – KVB 69/23
Authors: Fabig Tobias 
Published: December 2024

Zusammenfassung
Amtliche Leitsätze:
a) Die Zuständigkeit des Bundesgerichtshofs in Verfahren nach § 19a GWB für Streitigkeiten gegen selbständig anfechtbare Verfahrenshandlungen ist nicht auf Beschwerden gegen Verwaltungsakte beschränkt, sondern erstreckt sich auch auf Beschwerden gegen sonstige Verfahrenshandlungen.
b) Den Geheimnisschutz nach § 30 VwVfG, der auf die Offenlegung von Informationen bei der Anhörung von Beteiligten nach § 56 Abs. 1 GWB anwendbar ist, können auch ungeschriebene Offenbarungsbefugnisse einschränken, insbesondere wenn eine Güterabwägung ergibt, dass das Geheimhaltungsinteresse hinter noch wichtigeren anderen Interessen zurücktreten muss.
c) Die Kartellbehörde darf Betriebs- oder Geschäftsgeheimnisse des von den Ermittlungen betroffenen Unternehmens für die Zwecke der Stellungnahme gemäß § 56 Abs. 1 GWB gegenüber Beigeladenen nur dann offenlegen, wenn dies verhältnismäßig ist, die Offenlegung mithin geeignet und erforderlich ist, die Ermittlungen des Bundeskartellamts zu fördern und das mit ihr verfolgte öffentliche Interesse an der Verfahrensförderung und die – insoweit gleichgerichteten – (Verfahrens-)Interessen des Beigeladenen das Geheimhaltungsinteresse des betroffenen Unternehmens im Einzelfall überwiegen.
Tendências de custos com insumos na produção de cana-de-açúcar: uma abordagem através da Simulação de Monte Carlo
Authors: Amorim Fernando Rodrigues , Silva Saulo André , Izeppe Fábio Roberto 
Published: December 2024

O Brasil é um dos principais players na produção de cana-de-açúcar, sendo o estado de São Paulo o maior produtor brasileiro. No entanto, os custos de produção dos insumos (fertilizantes, corretivo, inseticida, fungicida e herbicida) são alguns dos fatores que mais influenciam no custo total de produção. Há, na literatura, uma extensa quantidade de estudos focados nos custos de produção da cana-de-açúcar. No entanto, há uma lacuna em mostrar o impacto dos custos e sua tendência para o futuro próximo. Este trabalho foi realizado com o objetivo de analisar a tendência dos insumos citados. Foram realizadas projeções dos cenários para um período de 12 meses. Esses valores foram coletados mensalmente, por meio de entrevistas diretas, com cerca de 50 empresas especializadas. O método utilizado foi quantitativo, sendo realizado por meio de Simulação de Monte Carlo (SMC). Modelos matemáticos baseados em séries temporais foram utilizados como forma de fazer a previsão: Double Moving Average, (MMD); Tendência Amortecida Não Sazonal, (TANS); Suavização Exponencial Simples, (SES); Suavização Exponencial Dupla (SED) e ARIMA. Os resultados mostraram que os inseticidas Thiamethoxam e Limestone estão em tendência de alta. As demais entradas, indicaram o contrário. No entanto, a previsão é alta para o custo total neste período, sendo que os custos com fertilizantes formulados representam 82% do custo total/tonelada de cana-de-açúcar a $0,55, segundo levantamento de 76 % de nível de probabilidade realizado através da análise de frequência cumulativa SMC.
Impact of Gelatin Sponge on Reducing Pulmonary Hemorrhage in CT-Guided Lung Biopsies: A Propensity Score Matched Analysis
Authors: Xiao jincheng , ZHANG YONG , WANG YANDAN , Guan Weiwei , Luo Junpeng 
Published: December 2024

Abstract

Background: Gelatin sponges are widely used as embolic agents to reduce bleeding in various surgical procedures. This study aims to assess the effectiveness of gelatin sponges in decreasing pulmonary bleeding during CT-guided percutaneous transthoracic needle biopsy (PTNB).
Methods: A retrospective cohort study was conducted at Henan Cancer Hospital, including patients who underwent PTNB from January to December 2022. Patients were categorized based on the use of gelatin sponges. Propensity score matching generated 1052 matched pairs, and machine learning models were utilized to predict the risk of pulmonary hemorrhage.
Results: A total of 1826 patients (mean age 64 ± 10 years; 986 men) were analyzed. The use of gelatin sponges resulted in a 6.46% reduction in severe pulmonary hemorrhage compared to the non-gelatin sponge group (p = 0.034). Logistic regression identified gelatin sponges as a significant protective factor (coefficient: -0.28, p = 0.029).
Conclusions: Gelatin sponges significantly reduce the risk of pulmonary hemorrhage in PTNB procedures, suggesting a potential improvement in patient safety and clinical outcomes.
Analysis and Control of the Causes of the Uplift of the Invert of Deep Tunnels
Authors: Li Chunlin , Wu Yan 
Published: December 2024

Abstract

When traversing a complex and fractured geological formation, a deep-buried highway tunnel in Yunnan Province encountered a significant uplift problem in the invert. The causes of the tunnel's uplifted section were analyzed through on-site observations and monitoring of the lining structure's deformation, combined with numerical simulation methods. The results indicate that the primary factors leading to the invert uplift are the softening of the surrounding rock at the invert base due to water seepage and the high water pressure in the fractured zone. The softening of the surrounding rock is crucial to the safety of the inverted uplift structure. Based on the tunnel’s engineering characteristics and the causes of the invert uplift, remediation measures such as “enhancing the drainage system, grouting with steel flower pipes, and demolishing and replacing the invert” were adopted. These measures effectively controlled the invert uplift. After the remediation, the convergence rate of the secondary lining decreased, and the deformation stabilized, indicating that the invert uplift remediation plan was reasonable and effective.
percutaneous endoscopic interlaminar lumbar decompression for intraspinal tophaceous gout surrounded by dural sac: a case report and literature review
Authors: Xu Chen , Dong Jinwang , Dong Liang 
Published: December 2024

Abstract

Background
Intraspinal tophaceous gout is a rare causative factor for spinal stenosis and neurological impairment. The most common treatment is laminectomy with or without fusion through an open approach. Yet, this excessively destroys normal tissues such as the lamina, facet joints, posterior ligamentous complex, and paravertebral muscles, increasing the risk of postoperative spinal instability and chronic back pain. The aim of current study was to analyze the surgical efficacy of percutaneous interlaminar endoscopy in the treatment of intraspinal tophaceous gout encased by the dural sac.
Case presentation:
A 31-year-old male complained of back pain and radiative pain in the right lower extremities for one year. Preoperative dual-energy CT (DECT) showed patchy extensive urate crystal deposition in the L4-L5 spinal canal and multiple facet joints. The patient underwent percutaneous endoscopic decompression via lumbar interlaminar approach. Multiple chalky white mass was found compressing the dural sac and nerve roots endoscopically. Pathologic results confirmed the diagnosis of lumbar intraspinal tophi. Postoperative MRI showed no significant compression of the dural sac and nerves, and CT showed no significant destruction of the facet joints. The patient's symptoms improved rapidly following the procedure.
Conclusion
Intraspinal tophaceous gout is rare. DECT is highly recommended for diagnosis when suspecting intraspinal tophaceous gout. This study reports a case of percutaneous endoscopic treatment of a patient with intraspinal tophaceous gout encased by the dural sac. We believe this surgical approach provides a new option for the treatment of lumbar spinal tophaceous gout because it provides adequate decompression without impaires joint stability. Percutaneous endoscopic decompression also has the following benefits: less bleeding, lower hospital expenses, and shorter hospitalization.
Associations between Hydroxychloroquine(HCQ) dose and the risk of flares in systemic lupus erythematosus
Authors: Zou Yadan , Peng Yuanhong , Zhong YuChao , Li Shengguang , Zhao Zhongxing , Yao Haihong 
Published: December 2024

Abstract

Objectives: To evaluate the relationship between Hydroxychloroquine (HCQ) dosage and the incidence of flares in Systemic Lupus Erythematosus (SLE).
Methods: In this retrospective cohort study, 703 SLE patients from multiple sites in China were analyzed from October 2020 to May 2023. Patients with a SLEDAI-2K score ≥4 were categorized into low-dose (≤6.7 mg/kg/day) and high-dose (>6.7 mg/kg/day) HCQ groups. The primary outcome was an SLE flare incidence, determined by therapy augmentation, an SLEDAI-2000 increase of ≥4 points, or hospitalization.
Results: Among the 703 patients, 45.5% experienced flares. Patients in the high-dose group had a significantly lower flare incidence (41.1%) compared to the low-dose group (51%, P=0.009). Cox regression analyses showed that higher HCQ doses were consistently associated with a reduced risk of flares (HR 0.93, 95% CI 0.86–0.99, P=0.03). When stratified by HCQ dosage, patients receiving≥6.7mg/kg/day had a lower risk of flares compared to those receiving <6.7mg/kg/day, with a hazard ratio of 0.76 (95% CI 0.61–0.96, P=0.019). Kaplan-Meier survival analysis confirmed a longer flare-free survival in the high-dose group (P=0.022). The smoothed dose HR curve indicated a clear trend of reduced flare risk for increased hydroxychloroquine dosages. Subgroup analyses show a clear trend without significant interaction effects.
Conclusions: Higher HCQ dosages are associated with a reduced risk of SLE flares and improved flare-free survival, supporting the optimization of HCQ dosing in SLE management.
Keywords: hydroxychloroquine, flare, lupus, systemic
The relationship between changes in body weight and cognitive function in the elderly
Authors: Zhong Yulu , Guo Bin , Wang Yaoyao , Li Yinan , Li Qinghai , Yu Xinjuan , Guo Jimei , Wang Tao 
Published: December 2024

Abstract

Background
Cognitive function is a major concern in aging society. Current studies on the impact of body weight changes on cognitive abilities present conflicting results. This study explored the relationship between weight changes during adulthood and cognitive function in later life.
Methods
Data were obtained from the National Health and Nutrition Examination Survey (NHANES) and a total of 5079 participants aged 60 years or older with recalled weight at young and middle adulthood were included. Absolute weight change was categorized into five groups: weight loss of at least 2.5 kg, weight change within 2.5 kg (reference group), weight gain of at least 2.5 kg but less than 10.0 kg, weight gain of at least 10 kg but less than 20.0 kg, and weight gain of at least 20.0 kg. Cognitive function was assessed using the Digit Symbol Substitution Test (DSST). Logistic regression models adjusted for covariates were used to compute the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between weight changes and cognitive function.
Results
From age 25 years to 10 years before survey, participants with small to moderate weight gain (increase of ≥ 2.5kg and < 10kg) exhibited a decreased risk of cognitive impairment compared to those with stable weight (weight change within 2.5 kg), with an OR of 0.64 (95%CI = 0.48 to 0.85, P = 0.003). For moderate to substantial weight gain (increase of ≥ 10kg and < 20kg), the OR was 0.66 (95%CI = 0.50 to 0.89, P = 0.007). From age 25 years to survey, the OR for moderate to substantial weight gain was 0.61 (95%CI = 0.46 to 0.79, P < 0.001). Restricted cubic spline indicated a U-shaped relationship between the absolute weight change and cognitive function.
Conclusions
Weight gain within certain limits during adulthood appears to be a protective factor against cognitive decline.
Analysis of caries risk behavior aggregation status and influencing factors in children aged 7-12 years in Jinzhou City
Authors: Li Hui , Xu Jianhui , Zhang Ke , Chai Mingzhu , Li Xin 
Published: December 2024

Abstract

Background
Non-brushing, snacking, and not utilizing oral services during mixed dentition are modifiable health risk factors for dental caries in school-age children. Therefore, this study aimed to evaluate the prevalence of dental caries in school-age children, the prevalence of clustered risk behaviors, and related influencing factors.
Methods
A total of 2266 students aged 7–12 years old from five districts and counties of Jinzhou were recruited by the multi-stage cluster random sampling method for a cross-sectional study. A questionnaire was collected from a parent or guardian with information on factors relevant to the child. Descriptive analysis was used to assess the prevalence of caries and clustered risk behaviors, and binary logistic regression analysis was used to estimate odds ratios and 95% confidence intervals for factors associated with clustered risk behaviors (P<0.05).
Results
Of the 2,266 children, ages 7–12, who responded to the study, 40.9% engaged in two or more concurrent oral health risk behaviors. Consuming snacks ≥ 2 times/day and not utilizing oral services were the two oral health risk behaviors that were most frequently clustered together. Binary logistic regression analysis showed that rural areas (OR = 0.642, P = 0.000), low education level of mothers (OR = 1.491, P = 0.000), and medium (OR = 1.277, P = 0.015) were independent influencing factors of oral health risk behavior clustering. After adjusting the three factors of gender, age, and urban and rural areas, the probability of clustering two and three oral health risk behaviors still increased with the severity of dental caries.
Conclusions
Oral health risk behaviors are common among school-age children, and rural children and children with low maternal education levels are the key groups for behavior improvement.