bluuebunny/crossref_metadata_2025_split huggingface dataset:
“What shall I do when I grow up?” Adolescents with cancer on the Youth Project in Milan play with their imagination and photography
Authors: Gaggiotti Paola , Veneroni Laura , Signoroni Stefano , Silva Matteo , Chisari Marco , Casanova Michela , Chiaravalli Stefano , Sironi Giovanna , Clerici Carlo Alfredo , Proserpio Tullio , Massimino Maura , Ferrari Andrea 
Published: August 2018

Introduction: Adolescents diagnosed with cancer have to temporarily stop pursuing several vital needs and making plans for the future. The Youth Project in Milan, Italy, focuses on such issues in young cancer patients’ personal lives. Uncertainty about the future had already emerged in several artistic projects designed to help these patients voice their emotions. Methods: We describe a project revolving around the question “What shall I do when I grow up?” Twenty-seven 15- to 26-year-old patients wrote a brief account of what they hoped to do as adults. Using theatrical costumes, they then dressed up in their chosen role for a photo shoot with a well-known professional photographer. The results were published in one of Italy’s main national dailies. Results: Participants reacted differently: some lightheartedly, others more seriously. They often expressed the wish to help others, desiring to return the support and protection they had received as patients. Another common theme concerned their need for normality. Conclusions: By writing about their dreams, these patients gave their doctors a glimpse of their inner world. The project proved an important complement to more conventional forms of psychosocial support and interaction with young patients.
Prevalence of Preventive and Symptomatic Drug Treatments in Hospice Care: An Italian Observational Study
Authors: Pasina Luca , Recchia Angela , Agosti Pasquale , Nobili Alessandro , Rizzi Barbara 
Published: August 2018

Background: The aim of pharmacotherapy in people at the end of life should be symptom control, more than prolonging life. Drugs for disease prevention should therefore be discouraged, but this is not the usual practice. The prevalence of unnecessary preventive drugs at the end of life is not well described, although some studies suggest it is common. Methods: This retrospective longitudinal study describes the prevalence of patients receiving preventive and symptomatic drug treatments at admission (T1) and before death (T2) in an Italian hospice. All adults admitted to the VIDAS hospice between March 2015 and February 2017 were included in the analysis. Results: The study sample comprised 589 end-of-life patients with a mean age of 75.3 (12.1) years. The mean number of drugs decreased from admission to the hospice to the time of death (mean [standard deviation]: 9.7 [3.4] and 8.7 [3.0]). All patients were appropriately treated with symptomatic drugs at T1 and T2, while there were significantly fewer patients from T1 to T2 with at least 1 preventive medication that could be considered for deprescription at the end of life (511, 86.8% and 286, 48.6%; P < .0001). Conclusions: Hospice admission can be associated with a definite reduction in the use of commonly prescribed preventive medications. However, about half of end-of-life patients can be prescribed avoidable medications. Drugs for peptic ulcer and gastroesophageal reflux disease and antithrombotics were the potentially avoidable preventive medications most frequently prescribed at admission to the hospice and before death.
Vascular access surgery can be safely performed in an ambulatory setting
Authors: Mestres Gaspar , Yugueros Xavier , Fontseré Nestor , Fierro Alejandro , Sala Xavier , Derosa Teresa Maria , Burrel Marta , Riambau Vincent 
Published: August 2018

Introduction: Ambulatory surgery is associated with lower costs, but there is lack of evidence of the safety for ambulatory vascular access surgery. The objective of this study is to substantiate the safety and effectiveness of performing vascular access surgery in an ambulatory setting. Methods: A review of our prospectively maintained database including all vascular access open surgeries (creations and repairs) performed by our Vascular Access Unit between 2013 and 2017 was compiled. Patient comorbidities, surgery details, hospital admission conditions, and 1-week and 1-month follow-up patency and complications (death, infection, bleeding, and readmission/reintervention) were scrutinized. Results: In the last 5 years, 1414 vascular access procedures were performed (67.8% access creations, 32.2% previous access repairs) in 1012 patients. Most surgeries were performed under local anesthesia (59.2%) or axillary plexus block (38.4%) and mainly in an ambulatory setting, without overnight hospital stays (90.9%). During the first postoperative week follow-up, 9 cases (0.6%) needed readmission or reintervention; significant infection materialized in 11 (0.8%) and 10 cases (0.7%) showed noteworthy hematoma or bleeding, only three (0.2%) requiring reintervention. The primary composite endpoint of 24-h death and 1 week readmission, reintervention, infection, or bleeding was 1.9% (27 cases); 1-month access failure was 6.2%. After univariate analysis, ambulatory settings were not related to higher rates of complications or readmissions. Conclusion: Arteriovenous access surgery can be safely performed in an ambulatory setting, in spite of complex cases, comorbidities, or the increasing implementation of axillary plexus blocks. Surgical results and patency are good, and complications necessitating readmission remain very low.
Home-based family focused rehabilitation for adolescents with severe Chronic Fatigue Syndrome
Authors: Burgess Mary , Lievesley Kate , Ali Sheila , Chalder Trudie 
Published: August 2018

Aims: The purpose of this article is to describe and evaluate a home based, family focused rehabilitative approach for severely affected housebound adolescents with Chronic Fatigue Syndrome (CFS). The main aims were to facilitate a return to school, improve physical functioning, reduce fatigue and assess any adverse effects of the intervention. Methods: Six housebound adolescents aged 11–18, diagnosed with CFS by a paediatrician, were assessed and treated at home by an experienced cognitive behaviour therapist. Outcomes were assessed 12 months after discharge from treatment. Results: At 12 months follow-up all patients had returned to either school or college, and physical functioning had improved in most of the patients. Fatigue had reduced in some. No adverse effects of the intervention were reported. Conclusion: Severely affected adolescents with CFS showed improved physical functioning and social adjustment after a home-based rehabilitative approach. Although several patients showed improvements in physical functioning, they did not all show substantial improvements in fatigue. At this crucial stage of development, it is important to offer young people and their parents hope by stating that improvement is possible.
Community pharmacists’ attitudes, opinions and beliefs about leadership in the profession: An exploratory study
Authors: Shikaze Davin , Arabi Muhammad , Gregory Paul , Austin Zubin 
Published: August 2018

Background: The profession of pharmacy needs effective leaders to navigate change. Indirect indicators suggest there are insufficient numbers of pharmacists who actually want to be leaders. A paucity of research limits our understanding of what motivates and demotivates pharmacists to be leaders. This exploratory study was undertaken to investigate community pharmacists’ attitudes, opinions and beliefs about leadership. Methods: Interviews with 38 pharmacists were conducted either in person or using telecommunication applications such as Skype. A semistructured interview guide was used to elicit comments about leadership in general and in pharmacy, perceived leadership roles and barriers/enablers to leadership. Data were analyzed using Chan and Drasgow’s motivation-to-lead framework. Results: Key barriers to assuming leadership roles included lack of education/support, inadequate compensation, concerns about work-life balance, time constraints and a generalized discontent about leadership in society and in the profession. Discussion: While some of these barriers could be addressed through formal education (such as conflict management training) or through managerial influence (e.g., remuneration or scheduling to improve work-life balance), some (such as cynicism about leadership) will be more challenging to address. The need to address these barriers will grow as the need for new and emerging leaders in pharmacy continues to evolve.
Asymptomatic reference values for the Disability of Arm, Shoulder and Hand and Patient-Rated Wrist/Hand Evaluation – electronic data collection and its clinical implications
Authors: McLean James M. , Hasan Afsana P. , Willet Jake , Jennings Matthew , Brown Kimberly , Goodwins Laura , Goetz Tom 
Published: August 2018

The purpose of this study was to establish normal asymptomatic population values for the Disability of Arm, Shoulder and Hand and Patient-Rated Wrist/Hand Evaluation in healthy, asymptomatic individuals of different age, gender, ethnicity, handedness and nationality, using electronic data collection. Two-hundred and ninety-two Australian and 293 Canadian citizens with no active wrist pain, injury or pathology in their dominant hand, were evaluated. Participants completed an electronically administered questionnaire and were assessed clinically. There was no statistically significant association between both wrist scores and nationality. There was a statistically significant association between both wrist scores and age, demonstrating that as age increased, normal wrist function declined. This study has established an electronic, asymptomatic control group for future studies using these scores. When using the Disability of Arm, Shoulder and Hand and Patient-Rated Wrist/Hand Evaluation, the control group can be sourced from a pre-established control group within a database, without necessarily being sourced from the same country of origin. Level of evidence: II
Patient-centred outcomes in lateral elbow tendinopathy: A systematic review of available evidence in UK populations
Authors: Evans Jonathan P , Smith Chris , Porter Ian , Gangannagaripalli Jaheeda , Goodwin Vicki , Valderas Jose 
Published: August 2018

Background For Patient-Reported Outcome Measures to be useful, they must have evidenced reliability, validity and responsiveness in both the condition and population of interest. The aim of this study is to systematically review the evidence for Patient-Reported Outcome Measures in UK patients with lateral elbow tendinopathy. Methods A systematic search was performed in Ovid MEDLINE, Embase and CINAHL. Studies were included if reporting administration of Patient-Reported Outcome Measures in UK populations with lateral elbow tendinopathy. Patient-Reported Outcome Measures characteristics and target populations were assessed using a structured classification system. Patient-Reported Outcome Measures reporting in randomised controlled trials was assessed against Consolidated Standards of Reporting Trials (CONSORT) standards (Patient-Reported Outcome extension). Results A total of 16 articles were included. Out of seven different Patient-Reported Outcome Measures, there was evidence of partial validation for five. The assessment of validity, reliability and responsiveness of all Patient-Reported Outcome Measures in lateral elbow tendinopathy UK populations extended to just 20 individual patients. No articles conformed to the CONSORT Patient-Reported Outcome extension standards. Conclusion There exists a paucity of data on the psychometrics of Patient-Reported Outcome Measures in UK lateral elbow tendinopathy populations. Without these data, trial design and interpretation are significantly hindered. The high prevalence of this condition and significant volume of studies being conducted into novel treatments highlight the need for this knowledge gap to be resolved.
Mental State Can Influence the Degree of Postoperative Axial Neck Pain Following Cervical Laminoplasty
Authors: Oshima Yasushi , Matsubayashi Yoshitaka , Taniguchi Yuki , Hayakawa Kentaro , Fukushima Masayoshi , Oichi Takeshi , Oka Hiroyuki , Riew K. Daniel , Tanaka Sakae 
Published: August 2018

Study design: A retrospective cohort study. Objective: To investigate factors influencing the incidence of moderate to severe postoperative axial neck pain following cervical laminoplasty. Methods: We reviewed 125 patients with cervical myelopathy who underwent double-door laminoplasty. The primary outcomes were the Numerical Rating Scale score (NRS score, 0-10) for neck pain, the Short Form 36 (SF-36) Health Survey score (Physical and Mental Component Summary scores [PCS and MCS, respectively]), and satisfaction. Imaging parameters on plain radiographs and magnetic resonance imaging were also evaluated. Patients with moderate to severe postoperative neck pain (NRS ≥ 5) were compared with those with no or mild neck pain (NRS ≤ 4). Results: One hundred and three patients (82%) with complete data were eligible for inclusion. There were 67 men and 36 women, with a mean age of 65 years (32-89 years). Twenty-five patients (23%) had moderate to severe postoperative axial pain (NRS ≥ 5) and were compared with the other 78 patients (NRS ≤ 4), which revealed several predictive factors, including female sex, the presence of preoperative neck pain, low postoperative PCS, low preoperative and postoperative MCS, and satisfaction with the treatment. Multivariable logistic regression analysis revealed that the postoperative MCS ( P = .002) was a risk factor for postoperative neck pain, although the preoperative MCS did not reach statistical significance ( P = .06). Conclusions: Patients with a low mental state, possibly before surgery, are at a high risk for postoperative axial neck pain. None of the imaging parameters were statistically different.
Value-based purchasing may unfairly penalize specialty centers performing combined liver–colon multivisceral resections
Authors: Leeds Ira L , Pronovost Peter J , Austin J Matthew , Haut Elliott R 
Published: August 2018

Background Some of the measures in value-based purchasing programs may be flawed due to inadequate risk adjustment. The purpose of this study was to examine the effect of the surgical casemix on surgical site infection rates using combined colectomy–hepatectomy resections as a test case. Methods We identified all adult patients undergoing elective colon surgery (2007–2013) in the National Inpatient Sample. We defined patients with a concurrent liver resection as “multivisceral resections.” Cases from each hospital were pooled by hospital identifier. The association between surgical site infection rate and the proportion of multivisceral resections performed was compared statistically. Findings were further tested for independence against hospital-level characteristics similar to risk-adjusted surgical site infection rate reporting. Results We identified 1014 hospitals performing 127,646 colon surgeries including 1168 (0.9%) multivisceral resections. The overall surgical site infection rate for multivisceral resection was 11.3% versus 1.6% for colectomy-only resections (p < 0.001). Simple linear regression demonstrated a 2.3% increase in a hospital’s surgical site infection rate for each 1% increase in the proportion of multivisceral resections performed. Multivariable linear regression demonstrated a preserved association. Conclusion A hospital’s rate of surgical site infections is positively associated with the proportion of multivisceral resections performed. Value-based purchasing programs should assess readily available data for further risk-adjustment inclusion.
Nomenclature of the Italian species of subtribe Conyzinae (Asteraceae: Astereae)
Authors: Iamonico Duilio 
Published: August 2018

AbstractThe typification of the names Conyza albida, Erigeron aegyptiacus and E. karvinskianus is discussed. Specimens from the B, LINN, and M are respectively designated as the lectotypes. The name C. albida is confirmed to be a heterotypic synonym of E. sumatrensis.
Narrating Near-Death Experience
Authors: Yee Thomas B. 
Published: August 2018

Abstract
Rarely do the worlds of classical music and video games collide explicitly; when they do, as in the 2007 JRPG Eternal Sonata, the result is of marked semiotic interest. The game’s complex metafictional plotline – involving multiple levels of narrative seeking to blend fantasy and reality – invites speculation and interpretation, particularly concerning its multivalent ending. This article uses recently developed analytical methods from the burgeoning field of musical semiotics to glean poignant interpretative meaning from the video game’s musical surface. By invoking music-theoretic work in intertextuality (Klein 2004), musical narrative (Almén 2008), and virtual agency (Hatten forthcoming), I argue that the video game’s musical score is a hermeneutic key for decoding artistic meaning in Eternal Sonata. Thus, ludomusicology contributes vitally to the semiosis of a video game’s meaning as a holistic, multimedia entity.
Zu Wasser und zu Land
Authors: Schmidt Karl Matthias 
Published: August 2018

Abstract
The paper lines up with studies that discuss the impact of the Jewish War and Vespasian’s advancement on the composition of the Gospel According toMark. Its topic is to show that Mk 4,35-41 and Mk 5,1-20 form a structural unity that insinuates the idea of a Christian peace, distinguished from Roman warfare and peace. Following those scholars who read Mk 5,1-20 as an allusion to the legio X Fretensis it is argued that Mk 4,35-41 and Mk 5,1-20 are tied together in light of the Roman peace propaganda that claimed apeace by land and by sea - as did Vespasian after the civil war, when he reminded the Romans of Octavian’s victory at fretum Siculum.
A User Perspective on the Vulnerabilities of Smart Watches: Is Security a Concern?
Authors: Popescul Daniela , Georgescu Mircea 
Published: August 2018

Abstract
Nowadays, we are witnessing a serious gain in popularity of the wearable smart things. A triumphalist language referring to their benefits can be noticed in mass media, revealing the hype in their adoption. Multiple advantages are perceived by the consumers, and work as positive drivers in the wearables market. Yet, there is little awareness regarding their privacy and security – such concerns are constantly expressed by academia, but usually ignored by buyers and manufacturers. Therefore, the purpose of this paper is to provide some preliminary insights into how do the users perceive vulnerabilities as interferences, frequent disconnections, hardware and software malfunctions, improper/difficult configuration etc. of hand worn devices. The analysis was realized by means of netnography, using emag.ro, the oldest and largest ecommerce site in Romania as online source. Inspired by a similar study conducted by (Genaro Motti & Caine, 2016), we selected and reviewed 931 comments posted by the buyers of the ten most popular smart watches, in order to identify the hardware, software and connectivity problems they faced while using the devices and to assess the awareness of the buyers to security and privacy issues. Also, an overview of the privacy and security policies published by selected smart watches’ manufactures was made, and some conclusion regarding the recommended future actions for wearable buyers, sellers and manufacturers were presented.
Family Ownership and Firm Performance: Romania Versus Germany
Authors: Schank Milena J. , Murgea Aurora , Enache Cosmin 
Published: August 2018

Abstract
A consistent body of research is dedicated to the relationship between the ownership structure of a firm and its financial performance. Despite that, the hitherto researches fail to reach a consensus regarding this issue since both negative and positive relationships have been found out. This paper examines the impact of ownership’s type (more precise the impact of the family ownership) on the firm’s financial performance. The analysis includes a comparison between family and non-family firm performance using a sample of 1,161 Romanian companies and 1,342 German companies for a time frame that range between 2008 to 2015. Based on different types of static panel data regressions: Pooled Ordinary Least Squares (OLS), Fixed Effects (FE), Random Effects (RE) and a corrective model (PCSE), the main findings show very different results for the two considered countries. Financial performance, expressed as return on assets (ROA) and return on equity (ROE) seems to be insensitive to family ownership in Romanian companies and statistically positively correlated with it for German ones. A potential explanation for these outputs consists in the different development circumstances in the two countries in the period that forego the Second War. At the same time, other variables considered do not show significant differences in outcome between the two countries: size, age, capital intensity and leverage negatively influence the financial performance of companies.
FDA Approval Summary: Pembrolizumab for Recurrent Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing PD-L1
Authors: Fashoyin-Aje Lola , Donoghue Martha , Chen Huanyu , He Kun , Veeraraghavan Janaki , Goldberg Kirsten B. , Keegan Patricia , McKee Amy E. , Pazdur Richard 
Published: August 2018

Abstract

On September 22, 2017, the U.S. Food and Drug Administration (FDA) granted accelerated approval for pembrolizumab (Keytruda, Merck & Co., Inc., Whitehouse Station, NJ) for the treatment of patients with recurrent, locally advanced or metastatic, gastric or gastroesophageal junction (GEJ) adenocarcinoma with disease progression on or after two or more systemic therapies, including fluoropyrimidine- and platinum-containing chemotherapy and, if appropriate, HER2/neu-targeted therapy, and whose tumors express programmed death-ligand 1 (PD-L1), as determined by an FDA-approved test. Approval was based on demonstration of durable overall response rate (ORR) in a multicenter, open-label, multicohort trial (KEYNOTE-059/Cohort 1) that enrolled 259 patients with locally advanced or metastatic gastric or GEJ adenocarcinoma. Among the 55% (n = 143) of patients whose tumors expressed PD-L1 based on a combined positive score ≥1 and either were microsatellite stable or had undetermined microsatellite instability or mismatch repair status, the confirmed ORR as determined by blinded independent central review was 13.3% (95% CI, 8.2–20.0); 1.4% had complete responses. Response durations ranged from 2.8+ to 19.4+ months; 11 patients (58%) had response durations of 6 months or longer, and 5 patients (26%) had response durations of 12 months or longer. The most common (≥20%) adverse reactions of pembrolizumab observed in KEYNOTE-059/Cohort 1 were fatigue, decreased appetite, nausea, and constipation. The most frequent (≥2%) serious adverse drug reactions were pleural effusion, pneumonia, dyspnea, pulmonary embolism, and pneumonitis. Pembrolizumab was approved concurrently with the PD-L1 immunohistochemistry 22C3 pharmDx test (Dako, Agilent, Santa Clara, CA) for selection of patients with gastric cancer for treatment with pembrolizumab based on PD-L1 tumor expression.

Implications for Practice
This report presents key information on the basis for Food and Drug Administration approval of pembrolizumab for the treatment of patients with locally advanced or metastatic gastric or GEJ adenocarcinoma whose tumors express PD-L1. The report discusses the basis for limiting the indication to patients with PD-L1-expressing tumors and the basis for recommending that PD-L1 status be assessed using a fresh tumor specimen if PD-L1 expression is not detected in an archival gastric or GEJ cancer specimen.