bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat
Authors: Atehortua-Martinez Luisa Alessandra , Masniere Cyriaque , Campolongo Patrizia , Chasseigneaux Stéphanie , Callebert Jacques , Zwergel Clemens , Mai Antonello , Laplanche Jean-Louis , Chen Huixiong , Etheve-Quelquejeu Mélanie , Mégarbane Bruno , Benturquia Nadia 
Published: January 2019

Background: The substantial increase in use of 3,4-methylenedioxypyrovalerone (MDPV), a popular recreational synthetic cathinone, has raised legitimate questions about its behavioral consequences and abuse liability. Aims: The aim of this study was to study MDPV-induced neurobehavioral effects in the rat, using different paradigms traditionally developed to study drug-attributed addictive properties. Methods: Different patterns of intraperitoneal 3 mg/kg MDPV administration were investigated. Consequences on rat horizontal locomotion and behavior of acute, intermittent (once daily dosing over 10 days), and binge (three-time daily dosing for 3 days) MDPV administration as well as challenge after 10 day MDPV withdrawal were studied. The dopamine receptor-D1 antagonist, SCH23390, was bilaterally infused in the nucleus accumbens to determine the role of D1-receptors in MDPV-related effects on the associative memory recall using the conditioned place preference paradigm. In addition, in a separate experience using western blot, we investigated the effects of chronic MDPV administration (four injections during 24 h) on ΔFosB expression in the nucleus accumbens, caudate putamen, and prefrontal cortex. Results: Acute MDPV administration increased stereotypies and open arm entries in the elevated plus maze while SCH23390 abolished MDPV-induced enhancing effects on memory consolidation. Intermittent MDPV administration resulted in sensitization of MDPV-induced locomotor effects and tolerance during the following challenge. With binge MDPV administration, locomotor activity was not altered despite tolerance onset after challenge. SCH23390 abolished MDPV-induced conditioned place preference. Chronic MDPV administration induced ΔFosB accumulation in the nucleus accumbens, caudate putamen, and prefrontal cortex. Conclusions: Our findings clearly show that MDPV produces profound behavioral alterations mediated by the activation of the dopaminergic system similarly to other amphetamines.
At the Turning Point: The Commission in 1978
Authors: Baer William J. 
Published: January 2019

This article examines the Federal Trade Commission in 1978—at the midpoint of the last twenty years of its history. The year 1978 saw the Commission at the height of its powers and influence. Over the prior ten years its mandate had been significantly expanded by a supportive Congress and successive administrations. Its docket of consumer protective initiatives, antitrust actions and economic studies was full. There seemed little that the Commission was reluctant to challenge or legally unable to accomplish. Nineteen seventy-eight also was the point at which the tide turned, when growing dissatisfaction with regulation generally and with a number of specific FTC initiatives produced a strong backlash that tended to overshadow the Commission's many accomplishments and, for a time, imperiled the agency's existence. Congress relieved the crisis in 1980 by passing legislation which preserved the Commission's basic statutory mandate but imposed restrictions on certain rule-making proceedings and established procedural safeguards on the future exercise of the agency's authority. Therefore, the Commission began to change direction. With the advent of the Reagan Administration, a more cautious and restrained attitude ensued, and the Commission in recent years has significantly reduced the number and range of activities it has undertaken. Thus, 1978 was a critical point in the agency's history, both when compared to where the agency had been, and to the direction it took thereafter.
What can we Learn from the Informational Content of Cigarette Advertising? A Reply and Further Analysis
Authors: Ringold Debra Jones , Calfee John E. 
Published: January 2019

“Once more the industry is back to its traditional and usually successful course—advertising flavor, taste and pleasure against a backdrop of beaches, ski slopes and languid lakes. It is a formula that works, …. And this new mood in advertising will probably prevail for some time, now that the FTC has insisted that wildly competitive copy is generally distasteful.” Printers Ink, Dec. 27, 1960, p. 37, celebrating the Federal Trade Commission's ban on tar claims, nicotine claims and all advertising references to the physical effects of smoking.
The Effects of Nutrition Package Claims, Nutrition Facts Panels, and Motivation to Process Nutrition Information on Consumer Product Evaluations
Authors: Keller Scott B. , Landry Mike , Olson Jeanne , Velliquette Anne M. , Burton Scot , Andrews J. Craig 
Published: January 2019

In a laboratory experiment using a between-subjects design, the authors examine the effects on nutrition and product evaluations of nutrition claims made (e.g., “99% fat free; ” “low in calories ”) on a product package, product nutrition value levels, and enduring motivation to process nutrition information. Enduring motivation is shown to moderate the effects of product nutrition value on consumer evaluations. Also, nutrition claims interact with product nutrition value in affecting consumer perceptions of manufacturer credibility. Given the availability of nutrient levels in the Nutrition Facts panel on the back of the mock package, nutrition claims on the front of the package generally did not affect positively consumers’ overall product and purchase intention evaluations. The authors discuss some implications of these findings, suggestions for further research, and study limitations. 1 1. The generalizability of the findings from this laboratory study may be restricted because the mock package used as the stimulus was examined outside of an actual in-store purchase environment. Because consumers in store settings may spend less time and care examining Nutrition Facts panels and are subject to a variety of other influences (Cole and Balasubramanian 1992), findings from this study may not generalize to such settings.
Silicone oil droplets in repackaged anti–vascular endothelial growth factors for intravitreal injections: In search of the main source of contamination
Authors: Olea José Luis , Gómez-Resa María , Cervera-Peris María Mercedes , Aragón Juan Antonio 
Published: January 2019

Introduction: Repackaging of anti–vascular endothelial growth factors in polypropylene syringes lubricated with silicone oil for intravitreal use is associated with the presence of intravitreal silicone oil droplets. The objective of this study is to assess how the use of silicone-free syringes (for storage and/or administration) would reduce the amount of silicone oil droplets in the product to be administered. Methods: Two 16 mL vials of bevacizumab were repackaged at the compounding pharmacy to obtain four sets of product, each consisting of three 1.2 mL tubes of the drug repackaged in different ways. Set A was repackaged according to routine practice, that is, the drug was placed into 1 mL siliconized syringes and 60 µL aliquots were extracted with 0.5 mL insulin siliconized syringes until reaching 1.2 mL. In set B, a 1-mL silicone-free syringe was used, followed by a 0.5 mL siliconized syringe. In set C, only 0.5 mL siliconized syringes were used. In set D, only the 1-mL silicone-free syringe was used. Micro-Flow Imaging technology was used for quantifying silicone oil droplet–like particles below 25 µm. Results: Silicone oil droplet–like particles were absent in set D. Set C had the highest average frequency of these particles, which was much lower in sets A and B. Set B had the lowest frequency. Conclusion: 0.5 mL insulin syringes with staked-in needles used for supplying the product seem to be the main source of silicone oil contamination in repackaged anti–vascular endothelial growth factors. Silicone-free insulin syringes with staked-in needles would be strongly recommended for supplying anti–vascular endothelial growth factor intravitreal injections from compounding pharmacies.
Impact of renal function on mid-term outcomes in heart failure patients treated with tolvaptan
Authors: Fujioka Kensuke , Mizuno Sumio , Ichise Taro , Matsui Takao , Hirase Hiroaki , Yamaguchi Masato , Aoyama Takahiko , Yamagishi Masakazu , Fujino Noboru , Kawashiri Masa-aki , Hayashi Kenshi 
Published: January 2019

Background: Although tolvaptan, an electrolyte-free water diuretic for congestive heart failure (HF), is reported to have no effect on long-term mortality or HF-related morbidity, there may exist some subgroups of patients who may receive beneficial effect of tolvaptan. The purpose of this study was to identify clinical factors associated with mid-term effect of tolvaptan on clinical outcomes of patients who discharged after acute HF. Methods: We retrospectively analyzed 140 patients (88 male; mean age, 77.1 ± 11.0 years) with acute HF who received tolvaptan (initial dose 8.6 ± 3.6 mg/day) during their hospitalization. They were divided into two groups according to how the tolvaptan was used at discharge; 77 in the tolvaptan-continued group and 63 in the discontinued group. Results: The Cox proportional hazards model revealed that eGFR was the only independent predictor for the occurrence of mid-term cardiac events (composite of re-hospitalization due to HF and all-cause death; aHR = 0.9870, p = 0.02597). The Kaplan–Meier survival curves of the two groups demonstrated no difference in cumulative event-free rates. In the subgroup with preserved renal function at admission (eGFR ⩾ 30 ml/min/1.73 m2), the continuous use of tolvaptan increased composite events (aHR = 2.130, p = 0.02549). Conclusions: The continuous use of tolvaptan after discharge did not affect mid-term cardiac events of HF overall but may be associated with increased cardiac events in the subgroup with preserved renal function. These findings suggest that the tolvaptan administration might need to be limited to treatment of in-hospital acute HF.
Inertial measurement unit-based pose estimation: Analyzing and reducing sensitivity to sensor placement and body measures
Authors: Kianifar Rezvan , Joukov Vladimir , Lee Alexander , Raina Sachin , Kulić Dana 
Published: January 2019

Introduction Inertial measurement units have been proposed for automated pose estimation and exercise monitoring in clinical settings. However, many existing methods assume an extensive calibration procedure, which may not be realizable in clinical practice. In this study, an inertial measurement unit-based pose estimation method using extended Kalman filter and kinematic chain modeling is adapted for lower body pose estimation during clinical mobility tests such as the single leg squat, and the sensitivity to parameter calibration is investigated. Methods The sensitivity of pose estimation accuracy to each of the kinematic model and sensor placement parameters was analyzed. Sensitivity analysis results suggested that accurate extraction of inertial measurement unit orientation on the body is a key factor in improving the accuracy. Hence, a simple calibration protocol was proposed to reach a better approximation for inertial measurement unit orientation. Results After applying the protocol, the ankle, knee, and hip joint angle errors improved to [Formula: see text], and [Formula: see text], without the need for any other calibration. Conclusions Only a small subset of kinematic and sensor parameters contribute significantly to pose estimation accuracy when using body worn inertial sensors. A simple calibration procedure identifying the inertial measurement unit orientation on the body can provide good pose estimation performance.
RETRACTED ARTICLE: Probiotic assisted weight management as a main factor for glycemic control in patients with type 2 diabetes: a randomized controlled trial
Authors: Khalili Leila , Alipour Beitullah , Asghari Jafarabadi Mohammad , Hassanalilou Tohid , Mesgari Abbasi Mehran , Faraji Ismail 
Published: January 2019

Abstract
Objectives
To evaluate the effect of Lactobacillus casei 01 on dietary intake, body weight, and glycemic control in patients with T2DM.

Method
Forty patients with T2DM (n = 20 for each group) were assigned into two groups in present trial. The patients in the probiotic group received a daily capsule containing a minimum of 108 CFU of L. casei 01 for 8 week. The placebo group took capsules filled with maltodextrin for the same time period. Dietary intake questionnaires and anthropometric measurements were collected, and the participants were assessed by an endocrinologist at baseline and at the end of the trial.

Results
Lactobacillus casei 01 supplementation significantly decreased total energy, carbohydrate, fat, and protein intake compared with placebo (p = 0.001, p = 0.002, p = 0.009, p = 0.001; respectively). Moreover weight, BMI, and waist circumference were significantly decreased in intervention group compared with placebo group (p < 0.001; p < 0.001; p = 0.029; respectively). In comparison with placebo group serum fetuin-A level, fasting blood sugar, insulin concentration, and insulin resistance were significantly decreased (p = 0.023, p =0.013, p = 0.028; p = 0.007; respectively), and serum SIRT1 level was significantly increased (p = 0.040) in intervention group.

Conclusions
Lactobacillus casei 01 supplementation affected dietary intake and body weight in a way that improved fetuin-A and SIRT1 levels and glycemic response in subjects with T2DM. Affecting the fetuin-A and SIRT1 levels introduces a new known mechanism of probiotic action in diabetes management.
1H and 13C NMR Studies on New Ionic Plastic Crystals Constructed by Ellipsoidal Cations with [BEt3Me] Anion
Authors: Kotani Yuka , Honda Hisashi 
Published: January 2019

Abstract
Two new ionic plastic crystals of [NEtMe2Pr][BEt3Me] and [NEt2MePr][BEt3Me] were found. In contrast, the highest-temperature solid-phase of [NEtMe2Bu][BEt3Me] and [NEt2MeBu][BEt3Me] were assigned to rotator phases. Solid-state 1H and 13C nuclear magnetic resonance (NMR) measurements revealed that both the cations and anions perform isotropic reorientations in the plastic phase. Conversely, the cations of [NEtMe2Bu] and [NEt2MeBu] undergo rotation about an axis. Based on these results, it is revealed that ellipsoidal cations of [NEtMe2Pr]+ and [NEt2MePr]+ can form plastic crystalline phases with [BEt3Me]−. In the lower temperature solid-phase of the plastic phase, a rotator phase was also found in [NEtMe2Pr][BEt3Me] and [NEt2MePr][BEt3Me] salts. This is rarely reported in alkylammonium compounds with [BEt3Me]. 1H NMR spin-lattice relaxation time (T1) measurements showed that activation energies of isotropic reorientation were slightly large when compared to those reported in other ionic plastic crystals constructed with globular cations. This difference can be explained by assuming the aspect ratio. On differential scanning calorimetry (DSC) charts, small entropy changes were recorded at melting points of four compounds. These results support the observation that cations and anions have large degrees of freedom of motion in the highest-temperature solid-phases (plastic and rotator phases).
Isotropic Site-Site Dispersion Potential Constructed Using Quantum Chemical Calculations and a Geminal Auxiliary Basis Set
Authors: Yokogawa Daisuke 
Published: January 2019

Abstract
Dispersion interaction is one of the most important attractive intermolecular interactions. Because the dispersion interaction is always present, even for neutral molecules, and increases as the number of atoms in a molecule increases, accurate calculations with small computational costs are critical, especially for biosystems and condensed phase systems. In this study, we propose a site-site dispersion potential using a geminal auxiliary basis set that is local, isotropic, and free from empirical parameters. Our method correctly reproduced the Symmetry-Adapted Perturbation Theory (SAPT) data for C6 values and the dispersion energy surface between alkanes and alkenes.
Case Report: Three's a crowd: a case report examining the diagnostic and pharmacokinetic challenges in HIV-tuberculous meningitis-malaria co-infection
Authors: Ellis Jayne , Eneh Prosperity C. , Ssebambulidde Kenneth , Rutakingirwa Morris K. , Lamorde Mohammed , Rhein Joshua , Cresswell Fiona V. , Boulware David R. , Nicol Melanie R. 
Published: January 2019

In 2016, 10.4 million cases of tuberculosis (TB) were reported globally. Malaria also continues to be a global public health threat. Due to marked epidemiological overlap in the global burden of TB and malaria, co-infection does occur. An HIV-infected, 32-year-old male presented with a two-week history of headache with fevers to Mulago National Referral Hospital, Uganda. Five months prior, he was diagnosed with pulmonary TB. He endorsed poor adherence to anti-tuberculous medications. Mycobacterium tuberculosis in CSF was confirmed on Xpert MTB/RIF Ultra. On day 2, he was initiated on dexamethasone at 0.4mg/kg/day and induction TB-medications were re-commenced (rifampicin, isoniazid, ethambutol, pyrazinamide) for TBM. He continued to spike high-grade fevers, a peripheral blood smear showed P. falciparum parasites despite a negative malaria rapid diagnostic test (RDT). He received three doses of IV artesunate and then completed 3 days of oral artemether/lumefantrine. To our knowledge this is the first published case of HIV-TBM-malaria co-infection. TBM/malaria co-infection poses a number of management challenges. Due to potential overlap in symptoms between TBM and malaria, it is important to remain vigilant for co-infection. Access to accurate parasitological diagnostics is essential, as RDT use continues to expand, it is essential that clinicians are aware of the potential for false negative results. Anti-malarial therapeutic options are limited due to important drug-drug interactions (DDIs). Rifampicin is a potent enzyme inducer of several hepatic cytochrome P450 enzymes, this induction results in reduced plasma concentrations of several anti-malarial medications. Despite recognition of potential DDIs between rifampicin and artemisinin compounds, and rifampicin and quinine, no treatment guidelines currently exist for managing patients with co-infection. There is both an urgent need for the development of new anti-malarial drugs which do not interact with rifampicin and for pharmacokinetic studies to guide dose modification of existing anti-malarial drugs to inform clinical practice guidelines.
“Introduzione” au numéro 1 de Mnemosyne.
Authors: Barbalato Beatrice 
Published: January 2019

« Je ne suis pas une source » ha scritto Philippe Lejeune . Questa affermazione costituisce la linea portante della rivista Mnemosyne, un luogo dove riflettere in modo interdisciplinare sui documenti autobiografici non considerandoli solo come materiale utile per storici, antropologi, linguisti, ma come testi a parte intera. Per perseguire questo progetto la nostra attenzione si rivolge alla maniera con la quale un documento autobiografico sia strutturalmente congegnato.
costruzione dell’ Etos nell’imposizione di scrittura autobiografica in seno alla costellazione familiare.
Authors: Meurice Francine 
Published: January 2019

Deux constats semblent s’imposer au terme de cette analyse – non exhaustive – de la construction de l’éthos au sein de la constellation familiale : l’incidence, sur la réception des textes autobiographiques du dispositif communicationnel de l’APA et des ateliers d’écriture et l’incidence, sur la textualisation du récit autobiographique, de la médiation du déposant qui rend les frontières entre texte et paratexte moins étanches. Dans certains cas, la lisibilité autobiographique du texte livré aux archives du patrimoine autobiographique n’est possible qu’au prix de cette mise en scène inhérente au geste d’alimenter ce patrimoine autobiographique.
Cesure e continuità nelle autobiografie ‘armate’ in Italia
Authors: De Sabbata Lorenzo 
Published: January 2019

Questo articolo nasce da una lettura problematizzata di due scritti autobiografici prodotti da ex-militanti di organizzazioni armate di sinistra attive in Italia durante gli ‘anni di piombo’. Attraverso questi dispositivi letterari, gli ex-militanti intervengono in un processo di memorializzazione pubblica stratificato e corale. Prendendo posizione in un ‘dialogo’ con altre raffigurazioni - memorialistiche, giornalistiche e scientifiche - questi ex militanti (ri)producono rappresentazioni esistenziali, storiche e politiche della propria traiettoria personale e di quella dell’organizzazione di appartenenza.
L’obiettivo di questo articolo è di analizzare come i diversi autori abbiano individuato, narrativamente svelato e contestualizzato i punti di rottura e di continuità delle loro esperienze, concentrandosi in particolare sull’allontanamento dalla strategia armata. Se, in entrambi i casi, questo è descritto come un processo, l’analisi si concentra sulle diverse scelte evenemenziali che lo scandiscono temporalmente e sulla loro articolazione sul piano pubblico e personale.
Indicible ravissement – une vie (Comment écrire ?)
Authors: Viennet Denis 
Published: January 2019

Ces quelques notes de lecture traversent trois champs principaux : la philosophie (Badiou, Wittgenstein), la psychanalyse (Laplanche) et la littérature (Mandelshtam, Proust, Thoreau). L’hypothèse vers laquelle elles tendent est que la philosophie n’est pas discernable de la vie. L’existence ne peut ni se dire ni se taire, elle s’écrit. Elle est plus que peuvent les langues. L’art commence à partir d’une expérience sensible, un sentiment où l’on entrevoit comment le langage est peu, au regard de ce qui le dépasse. L’inscription artistique cherche à se tenir au moment de naissance de la sensation, sans bavarder, s’aventurant à en traduire les signes presque invisibles de béance.
«Mon frère François, il habitait à Ménilmontant»
Authors: Patrizio Marie-Ange 
Published: January 2019

Cet article n'est pas disponible au téléchargement en raison du refus de publication de l'auteur en open access
Il est toutefois disponible à la commande au format papier dans la version complète de la revue sur le site des Presses universitaires de Louvain
Théâtre otobiographique*. Entendre le récit de soi sur les scènes au XXe siècle
Authors: Saraczynska Maja 
Published: January 2019

À partir des théories d’Antonin Artaud, en passant par la mise en scène directe de Tadeusz Kantor et par le récit de soi d’Evguéni Grichkovets, jusqu’aux adaptations scéniques (Vis au long de la vie de Michèle Albo)… Autant d’exemples pour illustrer le phénomène paradoxal du théâtre autobiographique. Mon étude s’interrogera sur la place de l’oralité, de la voix du comédien et de l’ouïe du spectateur, de la musique et des effets sonores dans les spectacles réalisés à l’ère du théâtre visuel caractérisé par le rôle prépondérant de l’image. Je m’intéresserai à cet espace scénique particulier afin de démontrer l'impact des éléments sonores (voix, enregistrements, musique, sons, amplifications, figures de style, choralité, silence), sur la création d'un spectacle autobiographique, sur l’importance de la mémoire sensorielle (auditive), ainsi que sur le rôle que jouent des souvenirs sonores dans la reconstitution de l’histoire (personnelle et générale) sur scène.
Il destino di Medea tra Euripide e Alvaro
Authors: Mesirca Margherita 
Published: January 2019

Cet article n'est pas disponible au téléchargement en raison du refus de publication de l'auteur en open access
Il est toutefois disponible à la commande au format papier dans la version complète de la revue sur le site des Presses universitaires de Louvain