Hand Sanitizer Ekstrak Metanol Daun Mangga Arumanis (Mangifera indica L.)
Authors: Ningsih Dian Riana , Purwati Purwati , Zusfahair Zusfahair , Nurdin Ahmad 
Published: March 2019

<p>Komponen dasar yang terdapat dalam <em>hand</em><em> </em><em>sanitizer</em> yaitu senyawaan antibakteri alkohol dan triklosan. Triklosan<em> </em>merupakan zat antibakteri yang paling sering ditambahkan dalam <em>hand</em><em> </em><em>sanitizer</em>. Triklosan<em> </em>merupakan zat antibakteri yang paling sering ditambahkan dalam <em>hand</em><em> </em><em>sanitizer</em>. Namun, penggunaan triklosan dapat membuat bakteri kebal, mengganggu kerja hormon dan bersifat toksik. Senyawa aktif seperti flavonoid, alkaloid, steroid, polifenol, tanin, dan saponin pada ekstrak daun mangga arumanis <em>(Mangifera indica </em>L.) dapat digunakan sebagai antibakteri pengganti triklosan. Penelitian ini bertujuan untuk memformulasikan ekstrak metanol daun mangga arumanis sebagai gel <em>hand sanitizer</em><em> </em>dan karakterisasi sediaan tersebut. Karakterisasi sediaan gel <em>hand sanitizer </em>meliputi uji pH, uji daya sebar, konsistensi, homogenitas, dan uji aktivitas. Uji pH diperoleh pH dengan rentang 6,49 – 5,74. Kisaran pH tersebut telah memenuhi ketentuan SNI No. 06-2588. Karakterisasi uji daya sebar memperoleh rentang penyebaran 58,55 – 50,05 mm, dimana telah memenuhi ketentuan SNI No. 06-2588. Namun, pada konsentrasi 0 ppm pada hari ke 15 rentang penyebarannya tidak memenuhi SNI No. 06-2588. Sediaan memiliki konsistensi dalam bentuk gel yang homogen. Gel <em>hand sanitizer</em> ekstrak metanol daun mangga arumanis diuji aktivitasnya terhadap bakteri <em>Staphylococcus aureus</em> pada hari ke 0 dan 15 penyimpanan dengan zona hambat (ϕ) yang diperoleh sebesar 4,36 dan 10,35 mm dengan konsentrasi 5 ppm, dan 4,51 dan 12,12 mm dengan konsentrasi 10 ppm.</p><p><strong><span lang="EN">Hand </span><span lang="EN">sanitizer</span><span lang="EN"> of methanol extract of manggoes leaf (Mangifera indica L)</span>. </strong><span lang="EN-US">The main component</span><span>s</span><span lang="EN-US"> in hand</span><span lang="EN-US">sanitizer</span><span lang="EN-US">are</span><span lang="EN-US"> antibacterial compounds </span><span lang="EN-US">of</span><span lang="EN-US"> alcohol and triclosan. Triclosan is the most commonly added antibacterial agent in the hand</span><span lang="EN-US">sanitizer</span><span lang="EN-US">. </span><span>However</span><span>,</span><span lang="EN-US"> triclosan can make resistant</span><span> bacteria</span><span lang="EN-US">, hormones disrupt and toxic. </span><span>M</span><span lang="EN-US">ango leaf extract (<em>Mangifera indica</em> L.)</span><span> have a</span><span lang="EN-US">ctive compounds such as; flavonoids, alkaloids, steroids, polyphenols, tannins, and saponins </span><span>that </span><span lang="EN-US">can </span><span>be </span><span lang="EN-US">used as an antibacterial substitute for triclosan</span><span>.</span><span lang="EN-US">This research formulates mango lea</span><span>ves </span><span lang="EN-US">extract for hand sanitizer </span><span lang="EN-US">followed by its characterization.</span><span lang="EN-US"> The characterization includes pH measurement, dispersive power test, consistency, homogeneity, and activity test. The pH measurement obtains that the pH is within 6.49 – 5.74. It </span><span>complies with</span><span>I</span><span lang="EN-US">ndonesian </span><span>n</span><span lang="EN-US">ational </span><span>s</span><span lang="EN-US">tandard </span><span lang="EN-US">N</span><span>o</span><span lang="EN-US">. 06-2588 </span><span lang="EN-US">requirement. </span><span lang="EN-US">The d</span><span lang="EN-US">ispersive power test found dispersion value around 58.55 – 50.05 mm, which has fulfilled the SNI N</span><span>o</span><span lang="EN-US">. 06-2588 provisions</span><span lang="EN-US">. </span><span lang="EN-US">However, at 0 ppm the dispersive power </span><span lang="EN-US">did</span><span lang="EN-US"> not </span><span lang="EN-US">meet</span><span lang="EN-US">the </span><span lang="EN-US">SNI N</span><span>o</span><span lang="EN-US">. 06-2588. The formula shows a homogeneous gel. </span><span>Mango leaves extract <em>hand sanitizer</em> gel was tested for activity to <em>Staphylococcus aures</em> </span><span lang="EN-US">during 0 and 15 days of storage, the inhibition zone </span><span>(ϕ)</span><span lang="EN-US"> at 4.36 and 10.35 mm (5 ppm), 4.51 and 12.12 mm (10 ppm).</span></p>