bluuebunny/crossref_metadata_2025_split huggingface dataset:
Milk drinking and risk of hip fracture: the Norwegian Epidemiologic Osteoporosis Studies (NOREPOS)
Authors: Holvik Kristin , Meyer Haakon E. , Laake Ida , Feskanich Diane , Omsland Tone K. , Søgaard Anne-Johanne 
Published: December 2018

AbstractMilk provides energy and nutrients considered protective for bone. Meta-analyses of cohort studies have found no clear association between milk drinking and risk of hip fracture, and results of recent studies are contradictory. We studied the association between milk drinking and hip fracture in Norway, which has a population characterised by high fracture incidence and a high Ca intake. Baseline data from two population-based cohorts were used: the third wave of the Norwegian Counties Study (1985–1988) and the Five Counties Study (2000–2002). Diet and lifestyle variables were self-reported through questionnaires. Height and weight were measured. Hip fractures were identified by linkage to hospital data with follow-up through 2013. Of the 35 114 participants in the Norwegian Counties Study, 1865 suffered a hip fracture during 613 018 person-years of follow-up. In multivariable Cox regression, hazard ratios (HR) per daily glass of milk were 0·97 (95 % CI 0·92, 1·03) in men and 1·02 (95 % CI 0·96, 1·07) in women. Of 23 259 participants in the Five Counties Study, 1466 suffered a hip fracture during 252 996 person-years of follow-up. HR for hip fractures per daily glass of milk in multivariable Cox regression was 0·99 (95 % CI 0·92, 1·07) in men and 1·02 (95 % CI 0·97, 1·08) in women. In conclusion, there was no overall association between milk intake and risk of hip fracture in Norwegian men and women.
Mycorrhizal inoculation and application of cattle manure in field-grown maize in semiarid conditions
Authors: Lino Ingrid A. N. , Da Silva Danielle K. A. , Martins Júlio C. R. , Sampaio Everardo V. S. B. , Maia Leonor C. 
Published: December 2018

AbstractWe evaluated the effects of cattle manure and inoculation with arbuscular mycorrhizal fungi (AMF) in maize plants growing in a semiarid area of Brazilian north-east in 2012 and 2013. Three isolates of AMF (AcaulosporalongulaURM-FMA 07 and URM-FMA 03,ClaroideoglomusetunicatumUNIVASF 06A) were used, with or without the application of cattle manure, during two growing cycles. In the first year, significant effects of inoculation were detected for straw yield only when the manure was applied. In the second year, there was an interaction between fertilisation and inoculation for plant height and grain yield, with the highest values in the fertilised treatments. Inoculation withA. longulademonstrated that mycorrhizal inoculation in field-grown plants could be an alternative management for improving plant growth and grain yield, reducing the use of cattle manure. The AMF sporulation and mycorrhizal colonisation were improved after inoculation, andA. longulaURM-FMA 07 increased sporulation by more than 15 times while inoculation withC. etunicatumincreased sporulation by more than 3 times. The mycorrhizal inoculation is a management practice that can be useful for recovering or maintaining AMF infective propagules in soil, showing potential to be used in large-scale field conditions in Brazilian semiarid. Although mycorrhisation presents high agricultural relevance due to benefits promoted to the soil and plants, the knowledge about the factors influencing the interactions among microorganisms, soil and plants need to be broadened aiming to achieve successful crop management in semiarid regions.
Does long-term care coverage shape the impact of informal care-giving on quality of life? A difference-in-difference approach
Authors: van den Broek Thijs , Grundy Emily 
Published: December 2018

AbstractThe impact that providing care to ageing parents has on adult children's lives may depend on the long-term care (LTC) context. A common approach to test this is to compare whether the impact of care-giving varies between countries with different LTC coverage. However, this approach leaves considerable room for omitted variable bias. We use individual fixed-effects analyses to reduce bias in the estimates of the effects of informal care-giving on quality of life, and combine this with a difference-in-difference approach to reduce bias in the estimated moderating impact of LTC coverage on these effects. We draw on longitudinal data for Sweden and Denmark from the Survey of Health, Ageing and Retirement in Europe (SHARE) collected between 2004 and 2015. Both countries traditionally had generous LTC coverage, but cutbacks were implemented at the end of the 20th century in Sweden and more recently in Denmark. We use this country difference in the timing of the cutbacks to shed light on effects of LTC coverage on the impact care-giving has on quality of life. Our analyses show that care-giving was more detrimental for quality of life in Sweden than in Denmark, and this difference weakened significantly when LTC coverage was reduced in Denmark, but not in Sweden. This suggests that LTC coverage shapes the impact of care-giving on quality of life.
Powder X-ray diffraction of bendamustine hydrochloride monohydrate, C16H22Cl2N3O2Cl·H2O
Authors: Kaduk J. A. , Zhong K. , Blanton T. N. , Gates-Rector S. , Fawcett T. G. 
Published: December 2018

Bendamustine hydrochloride monohydrate (marketed as Treanda®) is a nitrogen mustard purine analog alkylator used in the treatment of chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas. Commercial bendamustine hydrochloride monohydrate crystallizes in the monoclinic space group P21/c (14), with a = 4.71348(4) Å, b = 47.5325(3) Å, c = 8.97458 (5) Å, β = 96.6515(8)°, V = 1997.161(23) Å3, and Z = 4. A reduced cell search in the Cambridge Structural Database yielded a previously reported crystal structure (Allen, 2002), which did not include hydrogens (Reck, 2006). In this work, the sample was ordered from Santa Cruz Biotechnology, and analyzed as received. The room-temperature crystal structure was refined using synchrotron (λ = 0.413896 Å) powder diffraction data, density functional theory (DFT), and Rietveld refinement techniques. Hydrogen positions were included as part of the structure, and recalculated during the refinement. The diffraction data were collected on beamline BM-11 at the Advanced Photon Source, Argonne National Laboratory. Figure 1 shows the powder X-ray diffraction pattern of the compound. The pattern is included in the Powder Diffraction File as entry 00-064-1508.
Opsin-based photopigments expressed in the retina of a South American pit viper,Bothrops atrox(Viperidae)
Authors: Katti Christiana , Stacey-Solis Micaela , Coronel-Rojas Nicole A. , Davies Wayne I.L. 
Published: December 2018

AbstractAlthough much is known about the visual system of vertebrates in general, studies regarding vision in reptiles, and snakes in particular, are scarce. Reptiles display diverse ocular structures, including different types of retinae such as pure cone, mostly rod, or duplex retinas (containing both rods and cones); however, the same five opsin-based photopigments are found in many of these animals. It is thought that ancestral snakes were nocturnal and/or fossorial, and, as such, they have lost two pigments, but retained three visual opsin classes. These are theRH1gene (rod opsin or rhodopsin-like-1) expressed in rods and two cone opsins, namelyLWS(long-wavelength-sensitive) andSWS1(short-wavelength-sensitive-1) genes. Until recently, the study of snake photopigments has been largely ignored. However, its importance has become clear within the past few years as studies reconsider Walls’ transmutation theory, which was first proposed in the 1930s. In this study, the visual pigments ofBothrops atrox(the common lancehead), a South American pit viper, were examined. Specifically, full-lengthRH1andLWSopsin gene sequences were cloned, as well as most of theSWS1opsin gene. These sequences were subsequently used for phylogenetic analysis and to predict the wavelength of maximum absorbance (λmax) for each photopigment. This is the first report to support the potential for rudimentary color vision in a South American viper, specifically a species that is regarded as being nocturnal.
1ML – Core and modules united
Authors: ROSSBERG ANDREAS 
Published: December 2018

AbstractML is two languages in one: there is thecore, with types and expressions, and there aremodules, with signatures, structures, and functors. Modules form a separate, higher-order functional language on top of the core. There are both practical and technical reasons for this stratification; yet, it creates substantial duplication in syntax and semantics, and it imposes seemingly unnecessary limits on expressiveness because it makes modules second-class citizens of the language. For example, selecting one among several possible modules implementing a given interface cannot be made a dynamic decision. Language extensions allowing modules to be packaged up as first-class values have been proposed and implemented in different variations. However, they remedy expressiveness only to some extent and tend to be even more syntactically heavyweight than using second-class modules alone. We propose a redesign of ML in which modules are truly first-class values, and core and module layers are unified into one language. In this “1ML”, functions, functors, and even type constructors are one and the same construct; likewise, no distinction is needed between structures, records, or tuples. Or viewed the other way round, everything is just (“a mode of use of”) modules. Yet, 1ML does not require dependent types: its type structure is expressible in terms of plain System Fω, with a minor variation of ourF-ing modulesapproach. We introduce both an explicitly typed version of 1ML and an extension with Damas–Milner-style implicit quantification. Type inference for this language is not complete, but, we argue, not substantially worse than for Standard ML.
Compressed Sensing of Scanning Transmission Electron Microscopy (STEM) With Nonrectangular Scans
Authors: Li Xin , Dyck Ondrej , Kalinin Sergei V. , Jesse Stephen 
Published: December 2018

AbstractScanning transmission electron microscopy (STEM) has become the main stay for materials characterization on atomic level, with applications ranging from visualization of localized and extended defects to mapping order parameter fields. In recent years, attention has focused on the potential of STEM to explore beam induced chemical processes and especially manipulating atomic motion, enabling atom-by-atom fabrication. These applications, as well as traditional imaging of beam sensitive materials, necessitate increasing the dynamic range of STEM in imaging and manipulation modes, and increasing the absolute scanning speed which can be achieved by combining sparse sensing methods with nonrectangular scanning trajectories. Here we have developed a general method for real-time reconstruction of sparsely sampled images from high-speed, noninvasive and diverse scanning pathways, including spiral scan and Lissajous scan. This approach is demonstrated on both the synthetic data and experimental STEM data on the beam sensitive material graphene. This work opens the door for comprehensive investigation and optimal design of dose efficient scanning strategies and real-time adaptive inference and control of e-beam induced atomic fabrication.
The Impact of Two Combined Oral Contraceptives Containing Ethinyl Estradiol and Drospirenone on Whole Blood Clot Viscoelasticity and the Biophysical and Biochemical Characteristics of Erythrocytes
Authors: Emmerson Odette , Bester Janette , Lindeque Barend G. , Swanepoel Albe C. 
Published: December 2018

AbstractVenous thrombosis is associated with combined oral contraceptive (COC) use. We investigated the impact of two ethinyl estradiol (EE) and drospirenone (DRSP) containing COCs (3 mg DRSP/20µg EE and 3µg DRSP/30µg EE) on the viscoelasticity of whole blood clots along with the biophysical and biochemical characteristics of erythrocytes. Thromboelastography (TEG) analysis showed a tendency toward a hypercoagulable state in the COCs groups that was more pronounced with higher EE concentrations. Light microscopy and scanning electron microscopy (SEM) showed rouleaux formation of erythrocytes and alterations to the erythrocyte shape for both COC groups, which was attributed to membrane damage. SEM analysis showed spontaneous activation of fibrin and platelets in the COC groups, along with interactions between erythrocytes and platelets and/or fibrin. Confocal microscopy confirmed compromised membrane integrity in the COC groups compared to controls. Global thrombosis test analysis showed increased platelet activation and low thrombolysis in both COC groups when compared to controls. In conclusion, DRSP/EE formulations impact erythrocytes’ biophysical and biochemical properties to cause a shift in hemostasis to a prothrombotic state. Although these effects are mostly subclinical the long-term effects and risks involved with the use of these hormones should be considered carefully for each individual.
Exploring Photothermal Pathways via in Situ Laser Heating in the Transmission Electron Microscope: Recrystallization, Grain Growth, Phase Separation, and Dewetting in Ag0.5Ni0.5 Thin Films
Authors: Wu Yueying , Liu Chenze , Moore Thomas M. , Magel Gregory A. , Garfinkel David A. , Camden Jon P. , Stanford Michael G. , Duscher Gerd , Rack Philip D. 
Published: December 2018

AbstractA new optical delivery system has been developed for the (scanning) transmission electron microscope. Here we describe the in situ and “rapid ex situ” photothermal heating modality of the system, which delivers >200 mW of optical power from a fiber-coupled laser diode to a 3.7 μm radius spot on the sample. Selected thermal pathways can be accessed via judicious choices of the laser power, pulse width, number of pulses, and radial position. The long optical working distance mitigates any charging artifacts and tremendous thermal stability is observed in both pulsed and continuous wave conditions, notably, no drift correction is applied in any experiment. To demonstrate the optical delivery system’s capability, we explore the recrystallization, grain growth, phase separation, and solid state dewetting of a Ag0.5Ni0.5 film. Finally, we demonstrate that the structural and chemical aspects of the resulting dewetted films was assessed.
Going home with baby: innovative and comprehensive support for new mothers
Authors: Olson Tonia , Bowen Angela , Smith-Fehr Julie , Ghosh Swagata 
Published: December 2018

AbstractShorter length of stay for postpartum mothers and their newborns necessitates careful community follow-up after hospital discharge. The vast amount of information given during the initial postpartum period can be overwhelming. New parents often need considerable support to understand the nuances of newborn care including newborn feeding. Primary health care and community services need to ensure there is a seamless continuum of care to support, empower, and educate new mothers and their families to prevent unnecessary hospital readmission and other negative health outcomes. The Healthy & Home postpartum community nursing program provides clinical communication and supports to bridge the gap between acute hospital and community follow-up care through home visits, a primary health care clinic, a breastfeeding center, a breastfeeding café, a postpartum anxiety and depression support group, bereavement support, and involvement in a Baby-Friendly Initiative™ coalition. Nurses working in the program have the acute care skills and resources to complete required health care assessments and screening tests. They are also international board-certified lactation consultants able to provide expert breastfeeding and lactation care. This paper describes how the Healthy & Home program has evolved over the past 25 years and offers suggestions to other organizations wanting to develop a postpartum program to meet the physical and mental health needs of postpartum families to promote maternal and infant wellbeing.
How will persistent low expected returns shape household economic behavior?
Authors: Horneff Vanya , Maurer Raimond , Mitchell Olivia S. 
Published: December 2018

AbstractMany believe that global capital markets will generate lower returns in the future versus the past. We examine how persistently lower real returns will reshape work, retirement, saving, and investment behavior of older persons using a calibrated dynamic life cycle model. In a low return regime, workers build up less wealth in their tax-qualified 401(k) accounts versus the past, claim social security benefits later, and work more. Moreover, the better-educated are more sensitive to real interest rate changes, while the least-educated alter their behavior less. Interestingly, the distribution of wealth is more uniform in periods of persistent low expected returns.
Efficient In‐Cloud Removal of Aerosols by Deep Convection
Authors: Yu Pengfei , Froyd Karl D. , Portmann Robert W. , Toon Owen B. , Freitas Saulo R. , Bardeen Charles G. , Brock Charles , Fan Tianyi , Gao Ru‐Shan , Katich Joseph M. , Kupc Agnieszka , Liu Shang , Maloney Christopher , Murphy Daniel M. , Rosenlof Karen H. , Schill Gregory , Schwarz Joshua P. , Williamson Christina 
Published: December 2018

AbstractConvective systems dominate the vertical transport of aerosols and trace gases. The most recent in situ aerosol measurements presented here show that the concentrations of primary aerosols including sea salt and black carbon drop by factors of 10 to 10,000 from the surface to the upper troposphere. In this study we show that the default convective transport scheme in the National Science Foundation/Department of Energy Community Earth System Model results in a high bias of 10–1,000 times the measured aerosol mass for black carbon and sea salt in the middle and upper troposphere. A modified transport scheme, which considers aerosol activation from entrained air above the cloud base and aerosol‐cloud interaction associated with convection, dramatically improves model agreement with in situ measurements suggesting that deep convection can efficiently remove primary aerosols. We suggest that models that fail to consider secondary activation may overestimate black carbon's radiative forcing by a factor of 2.
High‐Resolution Constraints on Pacific Upper Mantle Petrofabric Inferred From Surface‐Wave Anisotropy
Authors: Russell Joshua B. , Gaherty James B. , Lin Pei‐Ying Patty , Lizarralde Daniel , Collins John A. , Hirth Greg , Evans Rob L. 
Published: December 2018

AbstractLithospheric seismic anisotropy illuminates mid‐ocean ridge dynamics and the thermal evolution of oceanic plates. We utilize short‐period (5–7.5 s) ambient‐noise surface waves and 15‐ to 150‐s Rayleigh waves measured across the NoMelt ocean‐bottom array to invert for the complete radial and azimuthal anisotropy in the upper ∼35 km of ∼70‐Ma Pacific lithospheric mantle, and azimuthal anisotropy through the underlying asthenosphere. Strong azimuthal variations in Rayleigh‐ and Love‐wave velocity are observed, including the first clearly measured Love‐wave 2θ and 4θ variations. Inversion of averaged dispersion requires radial anisotropy in the shallow mantle (2‐3%) and the lower crust (4‐5%), with horizontal velocities (VSH) faster than vertical velocities (VSV). Azimuthal anisotropy is strong in the mantle, with 4.5–6% 2θ variation in VSV with fast propagation parallel to the fossil‐spreading direction (FSD), and 2–2.5% 4θ variation in VSH with a fast direction 45° from FSD. The relative behavior of 2θ, 4θ, and radial anisotropy in the mantle are consistent with ophiolite petrofabrics, linking outcrop and surface‐wave length scales. VSV remains fast parallel to FSD to ∼80 km depth where the direction changes, suggesting spreading‐dominated deformation at the ridge. The transition at ∼80 km perhaps marks the dehydration boundary and base of the lithosphere. Azimuthal anisotropy strength increases from the Moho to ∼30 km depth, consistent with flow models of passive upwelling at the ridge. Strong azimuthal anisotropy suggests extremely coherent olivine fabric. Weaker radial anisotropy implies slightly nonhorizontal fabric or the presence of alternative (so‐called E‐type) peridotite fabric. Presence of radial anisotropy in the crust suggests subhorizontal layering and/or shearing during crustal accretion.
Probabilistic Tsunami Hazard Assessment in South China Sea With Consideration of Uncertain Earthquake Characteristics
Authors: Sepúlveda Ignacio , Liu Philip L.‐F. , Grigoriu Mircea 
Published: December 2018

AbstractIn this paper, we have conducted a probabilistic tsunami hazard assessment (PTHA) for Hong Kong (China) and Kao Hsiung (Taiwan), considering earthquakes generated in the Manila subduction zone. The new PTHA methodology with the consideration of uncertainties of slip distribution and location of future earthquakes extends the stochastic approach of Sepúlveda et al. (2017). Using sensitivity analyses, we further investigate the uncertainties of probability properties defining the slip distribution, the location, and the occurrence of earthquakes. We demonstrate that Kao Hsiung and Hong Kong would be significantly impacted by tsunamis generated by MW > 8.5 earthquakes in the Manila subduction zone. For instance, a specific MW 9.0 earthquake scenario is capable of producing tsunami amplitudes exceeding 4.0 and 3.5 m in Kao Hsiung and Hong Kong, respectively, with a probability of 50%. Despite the significant tsunami impact, great earthquakes have long mean return periods. As a result, the PTHA shows that Kao Hsiung and Hong Kong are exposed to a relatively small tsunami hazard. For instance, maximum tsunami amplitudes in the assessed locations of Kao Hsiung and Hong Kong exceed 0.32 and 0.18 m, respectively, with a mean return period of 100 years. The inundation hazard in populated areas is small as well, with mean return periods exceeding 1,000 years. Sensitivity analyses demonstrate that the PTHA can be affected by the uncertainties of the probability properties defining the slip distribution, the location, and the occurrence of earthquakes. However, PTHA results are most sensitive to the choice of the earthquake occurrence model.
Effect of Euxinic Conditions on Planktic Foraminifers: Culture Experiments and Implications for Past and Future Environments
Authors: Kuroyanagi Azumi , Toyofuku Takashi , Nagai Yukiko , Kimoto Katsunori , Nishi Hiroshi , Takashima Reishi , Kawahata Hodaka 
Published: December 2018

AbstractThe oceanic redox state is an essential determinant for life on Earth, and “anoxic events,” periods when large parts of the oceans were anoxic or euxinic (free hydrogen sulfide (H2S) present), may have substantially affected the oceanic biosphere. We present the first culture data showing the effects of euxinic conditions on planktic foraminifers. We cultured six species of planktic foraminifers (n = 31) in three treatments: ~2 mg H2S/L, ~9 mg H2S/L, and a control, without H2S. Under the H2S treatments, planktic foraminifers did not survive for more than 48 hr, and gametogenesis percentages were very low (8% and 17%), while the time to gametogenesis was short (less than 1 day). However, some species (e.g., Neogloboquadrina dutertrei) survived episodic or temporary exposure to H2S for a relatively short time (i.e., <24 hr, such as a tidal cycle), indicating species‐specific tolerance levels for H2S. The biological response of foraminifers to euxinia thus is fundamentally different from that of dysoxia (i.e., low dissolved oxygen; ~0.7 mg O2/L or ~22 μmol O2/L), when they survive, add chambers, feed, and undergo gametogenesis. The presence/absence of planktic foraminifers in sediments thus may help to elucidate the redox state of the euphotic zone in the oceans of the past, with planktic foraminifers absent in sediments deposited when euphotic waters became euxinic.