bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amylases and related glycoside hydrolases with transglycosylation activity used for the production of isomaltooligosaccharides
Authors: Casa-Villegas Mary , Marín-Navarro Julia , Polaina Julio 
Published: July 2018

Abstract
Isomaltooligosaccharides (IMOS) are sugars with health promoting properties that make them relevant for the pharmaceutical and food industries. IMOS have ample chemical diversity achieved by different α-glucosidic linkages and polymerization degrees, forming linear, branched and cyclic structures. Enzymatic synthesis of these compounds can be carried out by glycoside hydrolases (GHs) with transglycosylating activity. Different substrates are used for the synthesis: combinations of disaccharides and monosaccharides, or polymeric carbohydrates such as starch or dextran, which are converted to IMOS by a combination of hydrolysis and transglucosylation. In this review, the structural features of different enzyme families (GH31, GH13, GH70, GH57 and GH66) involved in IMOS synthesis are analysed. Focus is placed on structural traits that affect substrate and product specificity, and on the relative efficiency of transglucosylation and hydrolysis. Information resulting from site-directed mutagenesis and sequence alignments complements structural data to understand the role of specific residues in the performance of the enzymes. Altogether, these studies provide a frame of knowledge which may be used to design new enzymes with improved properties
Non-intrusive Tensor Reconstruction for High-Dimensional Random PDEs
Authors: Eigel Martin , Neumann Johannes , Schneider Reinhold , Wolf Sebastian 
Published: July 2018

Abstract
This paper examines a completely non-intrusive, sample-based method for the computation of functional low-rank solutions of high-dimensional parametric random PDEs, which have become an area of intensive research in Uncertainty Quantification (UQ).
In order to obtain a generalized polynomial chaos representation of the approximate stochastic solution, a novel black-box rank-adapted tensor reconstruction procedure is proposed.
The performance of the described approach is illustrated with several numerical examples and compared to (Quasi-)Monte Carlo sampling.
Automated testing environment and assessment of assignments for Android MOOC
Authors: Madeja Matej , Porubän Jaroslav 
Published: July 2018

Abstract
This paper describes the design of a testing environment for massive assessment of assignments for Android application programming courses. Specific testing methods and tool suggestions are continuously consulted with Wirecard company, dedicated to the development of mobile applications. The paper also analyzes the most common mistakes of students and suggests ways to uncover them through tests. Based on these, it creates tests, compares the performance of the emulator and real device tests, and the proposed tools are partially retrospectively tested on assignments from the previous run of a particular Android application programming course. From partial results the paper suggests changes for the course in relation to the testing environment and deploys it in the background of the course alongside the manual evaluation. It describes testing experience, analyzes the results and suggests changes for the future
p21Waf1 deficiency does not decrease DNA repair in E1A+cHa-Ras transformed cells by HDI sodium butyrate
Authors: Igotti Maria , Gnedina Olga , Morshneva Alisa , Svetlikova Svetlana , Pospelov Valery 
Published: July 2018

Abstract
This study aimed to explore a role of p21Waf1 in γH2AX foci formation and DNA repair as assessed by a Host-Cell Reactivation Assay in wild-type (p21Waf+/+) and p21Waf1-deficient E1A+Ras-transformed cells. p21Waf1+/+ cells have low γH2AX background compared to p21Waf1−/− cells. The treatment with histone deacetylase inhibitor (HDI) sodium butyrate (NaBut) causes to accumulation of γH2AX in p21Waf+/+ cells with little effect in p21Waf−/− cells. Moreover, NaBut inhibits DNA repair in wt cells but not in p21Waf1−/− cells. This could be explained by the weakening of GADD45 and PCNA proteins binding in NaBut-treated p21Waf1-expressing cells but not in p21Waf1−/− cells. We suggest that in wt-ERas cells NaBut activates both p21Waf1 expression and a release of p21Waf1 from the complexes with E1A that leads to suppression of DNA repair and promotes γH2AX persistency. The absence of p21Waf1 is by itself considered by the cell as stressful factor with formation of γH2AX. But the lack of p21Waf1 interferes with an inhibitory effect of NaBut to inhibit DNA repair and thereby to stop concomitant accumulation of harmful mutations. We conclude that p21Waf1 is directly involved in control of genome integrity and DNA repair acting through modulation of the components of the DNA repair machinery.
Markov-Chain Monte-Carlo methods and non-identifiabilities
Authors: Müller Christian , Weysser Fabian , Mrziglod Thomas , Schuppert Andreas 
Published: July 2018

Abstract
We consider the problem of sampling from high-dimensional likelihood functions with large amounts of non-identifiabilities via Markov-Chain Monte-Carlo algorithms. Non-identifiabilities are problematic for commonly used proposal densities, leading to a low effective sample size.
To address this problem, we introduce a regularization method using an artificial prior, which restricts non-identifiable parts of the likelihood function. This enables us to sample the posterior using common MCMC methods more efficiently. We demonstrate this with three MCMC methods on a likelihood based on a complex, high-dimensional blood coagulation model and a single series of measurements.
By using the approximation of the artificial prior for the non-identifiable directions, we obtain a sample quality criterion. Unlike other sample quality criteria, it is valid even for short chain lengths.
We use the criterion to compare the following three MCMC variants:
The Random Walk Metropolis Hastings, the Adaptive Metropolis Hastings and the Metropolis adjusted Langevin algorithm.
Spectra universally realizable by doubly stochastic matrices
Authors: Collao Macarena , Salas Mario , Soto Ricardo L. 
Published: July 2018

Abstract
A list of complex numbers Λ = { λ1, . . . , λn} is said to be realizable if it is the spectrum of an entrywise nonnegative matrix, and universally realizable if there exists a nonnegative matrix with spectrum Λ for each Jordan canonical form associated with Λ. The problem of characterizing the lists which are universally realizable is called the nonnegative inverse elementary divisors problem (NIEDP). This is a hard problem, which remains unsolved. A complete solution, if any, is still far from the current state of the art in the problem. In particular, in this paper we consider the NIEDP for generalized doubly stochastic matrices, and give new sufficient conditions for the existence and construction of a solution matrix. These conditions improve those given in [ELA 30 (2015) 704-720]
Interrelationship between Undrained Shear Strength from DMT and CPTU Tests for Soils of Different Origin
Authors: Młynarek Zbigniew , Wierzbicki Jędrzej , Stefaniak Katarzyna 
Published: July 2018

Abstract
The article presents test results on the use of the flat dilatometer test (DMT) to evaluate changes in undrained shear strength su in soils of various origins. Reference values for the undrained shear strength calculated with Marchetti’s original formula were su values obtained from the piezocone penetration tests. The tests were conducted at eight investigation sites in Poland, where five groups of soils were separated: loess-deluvial, loess-deluvial cemented, young till, aged till, and Pliocene clay. The soils exhibited varied overconsolidation effects. The study results revealed that the factors influencing the relationship between undrained shear strength and the KD coefficient from DMT test were various because of the origin, grain size distribution of the soils and cementation. In order to include the influence of overconsolidation and grain size distribution in calibration of su from DMT, a modified KD1 coefficient was introduced into the formula describing this relationship. The final solution was obtained with multiple linear regression. A relatively high statistical evaluation of this relationship was determined for aged till and deluvial and uncemented loess.
Compañía, buenos días, de pie. Construcción del cuerpo militar
Authors: Otálora María Camila 
Published: July 2018

Este trabajo se desarrolla en la Escuela Militar de Cadetes José María Córdova en Bogotá, donde a partir de un trabajo etnográfico de observación participante, entrevistas y captura de imágenes durante más de un año, se responde a la inquietud sobre cómo preparan los cadetes sus cuerpos en la institución hasta alcanzar el título de subtenientes del Ejército Nacional. La institución se encuentra en un momento coyuntural de cambios relacionados al posconflicto y al respeto de los derechos humanos que han transformado la estructura de enseñanza militar. De acuerdo a las nuevas necesidades de la institución, se busca una formación integral que le enseñea los cadetes formas básicas como comer, dormir, bañarse, el manejo estratégico de las armas y la formación académica universitaria, todo esto durante cuatro años de educación permanente, donde el cuerpo de los jóvenes se constituye como reflejo del cuerpo del Ejército.
Books Reviewed by: Kelly Schultz, Martin Chandler, Andrew Nicholson, Erika Reinhardt, Larry Laliberté
Authors: Simpkin Sarah 
Published: July 2018

Clemmer, Gina. The GIS 20 Essential Skills, third edition. Redlands, California: Esri Press, 2017. 182p. $49.99 US. ISBN 9781589485129.
Davidson, Peter. Atlas of Empires. Pennsylvania: Fox Chapel Publishing, 2018. 240p. $19.99 US. ISBN 978-1504800891.
Davies, John and Kent, Alexander J. The Red Atlas; How the Soviet Union secretly mapped the World. Chicago: University of Chicago Press, 2017. 272 p. $35.00 US. ISBN: 9780226389578.
Johnson, Alexander. The First Mapping of America: The General Survey of British North America. New York: I.B. Tauris & Co. Ltd., 2017. 320 p. $110 US (hardcover). ISBN: 978-1-806-442-9.
Shoalts, Adam. A History of Canada in Ten Maps, Epic Stories of Charting a Mysterious Land. Canada: Allen Lane, 2017. 344p. $36.00 CAD. ISBN 978-0-670-06946-0.
PENGARUH TOTALITAS KERJA DAN MODAL PSIKOLOGIS TERHADAP KEPUASAN KERJA DRIVER GOJEK DI JAKARTA SELATAN
Authors: Citradewi Ardisa , Soebandono J. P. 
Published: July 2018

This study aims to determine the effect of the work engagament and psychological capital to job satisfaction drivers gojek. Through this research is expected to find out how far the influence of the totality of work and psychological capital on the drivers of gojek. This research uses quantitative approach with regression analysis method, and validation test of construct using Confirmation Factor (CFA) technique. The sample numbered 175 drivers gojek. The sample of research was determined by using non probability sampling technique. The data collection instrument using Job Satisfaction Survey (JSS) developed by Spector, Utrecht Work Engagement Scale (UWES) was developed by Schaufeli and Bakker and Psychological Capital Questionner (PCQ-24) developed by Luthans, Avolio, et al., 2007. The results of this study indicate that there is a significant influence of the variable influence of work engagement and psychological capital with a significance value of 0.000 or p <0.05 to job satisfaction. So the nil hypothesis (Ho) that exist in the major hypothesis in this study was rejected. The result of the test of the minor hypothesis examining the influence of 7 IV, there are two nil hypothesis (Ho) rejected, it means that there are two IV that have significant effect on job satisfaction, the absorption and resilience variable, while the vigor variable, dedication, self efficacy, optimism and hope effect on job satisfaction. DOI:10.15408/tazkiya.v22i2.8405
Early Adolescents’ Digital Gameplay Preferences, Habits and Addiction / Preferencije, navike i ovisnost mlađih adolescenata o digitalnim igrama
Authors: Aleksić Veljko 
Published: July 2018

AbstractThe paper provides an empirically grounded innovative and unique insight into relations between digital gameplay preferences, habits and addiction. The research sample consisted of 1262 eleven-to-fifteen-year-old students from 22 Serbian schools. An adequate psychometric instrument was developed and evaluated as part of the research. The influence of socio-demographic factors on digital gameplay preferences, habits and addiction was analyzed. Research hypotheses have been proposed in accordance with research objectives. They have been confirmed since the obtained results support the existence of the relation between digital gameplay and addiction among early adolescents.Key words: digital games; early adolescents; gameplay addiction.---SažetakU radu se daje empirijski utemeljen inovativan i jedinstven uvid u odnose između preferencija, navika i ovisnosti o digitalnim igrama. Uzorak istraživanja sastojao se od 1262 učenika iz 22 škole u Srbiji, u dobi od 11 do 15 godina. Dio istraživanja odnosio se na razvoj i evaluaciju odgovarajućeg psihometrijskog instrumenta. Analiziran je utjecaj socio-demografskih čimbenika na preferencije, navike i ovisnost o digitalnim igrama. U skladu s istraživačkim ciljevima i zadaćama formulirane su istraživačke hipoteze, koje su potvrđene. Rezultati upućuju na postojanje veze između digitalnih igara i ovisnosti kod mlađih adolescenata.Ključne riječi: digitalne igre; mlađi adolescenti; ovisnost o igrama.
Digital Drama versus Digital Story: Do They Really Matter on Pre-Service EFL Teachers’ Attitudes towards Instructional Technologies and Material Developing Skills / Digitalna drama nasuprot digitalnoj priči: jesu li uopće važne za stajališta budućih učite
Authors: AKAY Cenk 
Published: July 2018

AbstractInstructional technologies and material designing are two important factors in English as a foreign language (EFL) learning. There are several applications which support the attitudes and skills of pre-service teachers in their undergraduate education. Digital drama and digital story are among them. While there is a satisfactory number of studies on digital story, there are a very few of them on digital drama. Actually, this paper has two main purposes. The first one is to raise an awareness of digital drama. The second one is to reveal the impact of these two digital applications on pre-service EFL teachers’ attitudes towards instructional technologies and material designing skills. The results indicated that, while the digital story application had a significant effect, the digital drama application had a liminal significant effect on their attitudes towards instructional technologies. On the other hand, both applications had an effect on the material designing skills of the target participants. Finally, the results suggested that using digital materials in class enhances pre-service teachers’ motivation to use instructional technologies and develop their material designing skills. Key words: digital drama; digital story; instructional technologies.---SažetakPrimjena nastavnih tehnologija i izrada materijala dva su važna čimbenika u učenju engleskog kao stranog jezika. Postoji nekoliko aplikacija koje pridonose razvoju stajališta i vještina dodiplomskih studenata, budućih učitelja. Među njima su digitalna drama i digitalna priča. Broj istraživanja o digitalnoj priči je zadovoljavajuć, ali samo je nekoliko istraživanja o digitalnoj drami. Ovaj rad zapravo ima dva glavna cilja. Prvi se odnosi na pokušaj razvijanja svjesnosti o digitalnoj drami, a drugi ukazuje na učinkovitost tih dviju digitalnih aplikacija kada su u pitanju stajališta budućih učitelja engleskog kao stranog jezika o vještinama potrebnim za primjenu tehnologija u nastavi i izradu materijala. Rezultati su pokazali da primjena digitalne priče ima značajan učinak, a da digitalna drama ima ograničeno značajan učinak na stajališta o nastavnim tehnologijama. S druge strane, obje su aplikacije za buduće učitelje učinkovite u pogledu vještina za izradu materijala. Na kraju, rezultati ukazuju na to da uporaba digitalnih materijala u nastavi poboljšava motivaciju budućih učitelja za primjenu nastavne tehnologije i razvija njihove vještine izrade materijala.Ključne riječi: digitalna drama; digitalna priča; nastavne tehnologije.
A School-Based Curriculum Development for the Teaching Principles and Methods Course/Izrada školskog kurikula za kolegij Nastavna načela i metode
Authors: Yeşilpınar Uyar Melis , Doğanay Ahmet 
Published: July 2018

Abstract The purpose of this study is to develop a school-based curriculum for the Teaching principles and methods course. The study was designed as action research. In this context, the implementation process was carried out in a 14-week period with the participation of 36 sophomore students taking the Teaching principles and methods course at a State University, Faculty of Education, Department of Classroom Teaching, in the fall semester of the academic year 2014/2015. Observations, interviews and document analysis were used to collect data. According to the findings, it was observed that the problems encountered in the implementation process were mainly associated with the insufficiency of the time allocated to the course for all learning outcomes in the guideline draft that directed the action plans, the functional implementation of peer assessment process, and the seating arrangement within the group. Most of these problems were tackled in the action research process so that the difficulties that students had during the course decreased, while the number of participants who found the implementations satisfactory increased.Key words: action research; school-based curriculum development; Teaching principles and methods course; teacher education.---SažetakCilj je ovog istraživanja izraditi školski kurikul za kolegij Nastavna načela i metode primjenom dizajna akcijskog istraživanja. U tom kontekstu provedba istraživanja trajala je 14 tjedana, a u njemu je sudjelovalo 36 studenata druge godine Učiteljskog fakulteta Državnog sveučilišta, smjera Razredna nastava, koji su pohađali kolegij Nastavna načela i metode u zimskom semestru akademske godine 2014./2015. Promatranje, intervju i analiza dokumenata koristili su se za prikupljanje podataka. Na temelju rezultata uočeno je da su problemi koji su se pojavili u procesu provedbe uglavnom povezani s nedovoljnom količinom vremena planiranog za kolegij kako bi se ostvarili svi ishodi navedeni u smjernicama koje su određivale akcijski plan, funkcionalnu provedbu kolegijalne evaluacije i raspored sjedenja za vrijeme nastave. Većina tih problema spomenuta je tijekom akcijskog istraživanja, pa je umanjen broj poteškoća s kojima su se studenti susretali tijekom kolegija, a broj se sudionika koji su smatrali da je njegova provedba zadovoljavajuća povećao.Ključne riječi: akcijsko istraživanje; razvoj školskog kurikula; kolegij Nastavna načela i metode; izobrazba nastavnika.
Transforming Tertiary EFL Learners’ Meta-Linguistic Knowledge and Practices: A Longitudinal Case Study/Preoblikovanje metalingvističkog znanja i metoda učenja engleskoga kao stranoga jezika na tercijarnoj razini: longitudinalna studija slučaja
Authors: Zhang Xiaodong 
Published: July 2018

Abstract This study reports on how the explicit teaching of language use as meaning-making in context (i.e., language use as a dynamic interaction between context, meaning, and linguistic features) impacted tertiary English as a foreign language (EFL) learners’ meta-linguistic knowledge of the English language, as well as their language learning practices. Based on a qualitative analysis of interviews, conversations, and written samples gathered from one college-level EFL student over one academic year, the study shows that the EFL student’s appropriation of a new meta-linguistic perspective of language use as meaning-making in context — which differed from her previous understandings of language use as de-contextualized sentential accuracy — was a process of interacting with diverse factors. These factors included her passion for challenging herself and constructing her professional identity. Additionally, over the year, the EFL student also adopted corresponding language literacy practices, which resonates with the endorsed language literacy valued by authentic English language communities.Key words: English as a foreign language; language learners; meaning-making; systemic functional linguistics; transition.---Sažetak Ovo istraživanje govori o načinu na koji je eksplicitno poučavanje upotrebe jezika putem stvaranja značenja u kontekstu (tj. upotrebe jezika kao dinamične interakcije između konteksta, značenja i lingvističkih obilježja) utjecalo na metalingvističko znanje studentice engleskoga kao stranoga jezika na tercijarnoj razini, kao i njezinih metoda učenja jezika. Utemeljeno na kvalitativnoj analizi intervjua, razgovora i pisanih uzoraka skupljenih tijekom jedne akademske godine od učenice engleskoga kao stranoga jezika na fakultetskoj razini, istraživanje pokazuje da je stjecanje nove metalingvističke perspektive upotrebe jezika kao stvaranja značenja u kontekstu – što se razlikovalo od prijašnjih spoznaja upotrebe jezika kao dekontekstualizirane rečenične točnosti – bio proces interakcije s različitim čimbenicima. Ti su čimbenici uključivali njezinu strast za izazovnim zadatcima i izgradnjom vlastitog profesionalnog identiteta. Dodatno, tijekom godine, učenica je također usvojila odgovarajuću razinu jezične pismenosti koja se podudara s prihvaćenom jezičnom pismenošću cijenjenom u autentičnim engleskim jezičnim zajednicama. Ključne riječi: engleski kao strani jezik; učenici jezika; stvaranje značenja; sistemska funkcionalna lingvistika; tranzicija.
Transmissible silver resistance readily evolves in high-risk clone isolates of Klebsiella pneumoniae
Authors: Hanczvikkel Adrienn , Füzi Miklós , Ungvári Erika , Tóth Ákos 
Published: July 2018

Silver is used extensively in both hospitals and outpatient clinics as a disinfectant coating agent on various devices. Resistance to silver was recently reported as an emerging problem inEnterobacteriaceae.Multidrug-resistant high-risk clones ofKlebsiella pneumoniaeare common causes of serious healthcare-associated infections worldwide posing a serious threat to patients. In this study, we investigated the capacity of both high-risk (CG14/15 and CG258) and minor clone strains ofK. pneumoniaeto develop resistance to silver. Resistance was inducedin vitroin silver-susceptible but otherwise multidrug-resistant clinical isolates. Genetic alterations in the silver-resistant derivative strains with regard to the silver-susceptible isolates were investigated by whole-genome sequencing. The transferability of high-level resistance to silver was also tested. We demonstrated that the high-level resistance to silver can quickly evolve as a consequence of a single-point mutation either in thecusS gene of the chromosomally encoded CusCFBARS efflux system and/or in thesilS gene of the plasmid-encoded Copper Homeostasis and Silver Resistance Island (CHASRI) coding also for a metallic efflux. The minimal inhibitory concentrations (MICs) of the strains increased from 4 mg/L (23.5 μM) AgNO3to >8,500 mg/L (>50,000 μM) AgNO3during induction. Harboring the CHASRI proved an important selective asset forK. pneumoniaewhen exposed to silver. Successful conjugation experiments usingEscherichia coliK12 J5-3Rifas recipient showed that high-level silver resistance can transmit between strains of high-risk clones ofK. pneumoniae(ST15 and ST11) and isolates from additional species ofEnterobacteriaceae. The lack of fitness cost associated with the carriage of the CHASRI in a silver-free environment and the presence of the RelEB toxin–antitoxin system on the conjugative plasmids could advance the dissemination of silver resistance. Our results show that multidrug-resistant high-risk clones ofK. pneumoniaeare capable of evolving and transmitting high-level resistance to silver. This observation should warrant a more judicious use of silver coated-devices to prevent the extensive dissemination of silver resistance.