bluuebunny/crossref_metadata_2025_split huggingface dataset:
RNA Polymerase II Transcription Attenuation at the Yeast DNA Repair Gene, DEF1, Involves Sen1-Dependent and Polyadenylation Site-Dependent Termination
Authors: Whalen Courtney , Tuohy Christine , Tallo Thomas , Kaufman James W , Moore Claire , Kuehner Jason N 
Published: April 2018

Abstract
Termination of RNA Polymerase II (Pol II) activity serves a vital cellular role by separating ubiquitous transcription units and influencing RNA fate and function. In the yeast Saccharomyces cerevisiae, Pol II termination is carried out by cleavage and polyadenylation factor (CPF-CF) and Nrd1-Nab3-Sen1 (NNS) complexes, which operate primarily at mRNA and non-coding RNA genes, respectively. Premature Pol II termination (attenuation) contributes to gene regulation, but there is limited knowledge of its prevalence and biological significance. In particular, it is unclear how much crosstalk occurs between CPF-CF and NNS complexes and how Pol II attenuation is modulated during stress adaptation. In this study, we have identified an attenuator in the DEF1 DNA repair gene, which includes a portion of the 5′-untranslated region (UTR) and upstream open reading frame (ORF). Using a plasmid-based reporter gene system, we conducted a genetic screen of 14 termination mutants and their ability to confer Pol II read-through defects. The DEF1 attenuator behaved as a hybrid terminator, relying heavily on CPF-CF and Sen1 but without Nrd1 and Nab3 involvement. Our genetic selection identified 22 cis-acting point mutations that clustered into four regions, including a polyadenylation site efficiency element that genetically interacts with its cognate binding-protein Hrp1. Outside of the reporter gene context, a DEF1 attenuator mutant increased mRNA and protein expression, exacerbating the toxicity of a constitutively active Def1 protein. Overall, our data support a biologically significant role for transcription attenuation in regulating DEF1 expression, which can be modulated during the DNA damage response.
Svetimkūnių iš viršutinės virškinimo trakto dalies endoskopinis šalinimas Respublikinėje Vilniaus universitetinėje ligoninėje: 25 metų patirtis
Authors: Kildušis Edvinas , Grigaliūnas Aurelijus , Žilevičė Laura 
Published: April 2018

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Nurytas svetimkūnis ar maistas, įstrigę viršutinėje virškinimo trakto dalyje, yra dažna klinikinė situacija skubios pagalbos skyriuose visame pasaulyje. Didžioji dauguma svetimkūnių pereina per virškinimo traktą ir natūraliai pasišalina su išmatomis, tačiau apie 1/5 ligonių prireikia svetimkūnius šalinti. Viršutinėje virškinimo trakto dalyje įstrigęs svetimkūnis yra antra pagal dažnumą (po kraujavimo) skubios endoskopijos priežastis.Atlikto retrospektyvaus aprašomojo tyrimo tikslas yra apžvelgti Respublikinės Vilniaus universitetinės ligoninės (RVUL) gydytojų ketvirčio amžiaus (25 metų) patirtį lanksčiu endoskopu šalinant svetimkūnius iš viršutinio virškinimo trakto. Galima teigti, kad kvalifikuoto specialisto atliekamas endoskopinis svetimkūnių šalinimas naudojant endoskopą su priedais: kilpa, krepšeliu ir žnyplėmis, yra efektyvus ir saugus būdas, lemiantis didelę procedūros sėkmę, ženkliai sumažinantis hospitalizacijos laiką ir chirurgijos (operacinio gydymo) poreikį.
Ašermano sindromas: klinikinis atvejis ir mokslinės literatūros apžvalga
Authors: Bužinskienė Diana , Drąsutienė Gražina , Zdanytė Kristina 
Published: April 2018

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Intrauterininės sąaugos – tai jungiamojo audinio formavimasis gimdos ertmėje. Šio proceso metu progresuoja endometriumo funkcijos sutrikimas, kuriam būdingi įvairūs klinikiniai simptomai, tokie kaip menstruacinio ciklo sutrikimai (hipomenorėja, dismenorėja ar amenorėja), pasikartojantys savaiminiai nėštumo nutrūkimai, nevaisingumas ir kt. Klinikinė intrauterininių sąaugų raiška yra vadinama Ašermano sindromu.Šio straipsnio tikslas – pristatyti Ašermano sindromo klinikinį atvejį, apžvelgti naujausius mokslinės literatūros šaltinius ir įvertinti problemos aktualumą. Pateikiamas 30 metų amžiaus pacientės klinikinis atvejis. Pacientė planine tvarka kreipėsi į gydytoją akušerį-ginekologą dėl nevaisingumo, kurio trukmė buvo 2 metai. Kitų nusiskundimų pacientė neišsakė, iš anamnezės buvo žinoma, kad moteris negimdžiusi, prieš dvejus metus pacientei buvo atliktas 8 savaičių trukmės nėštumo nutraukimas. Pirminės apžiūros metu, atlikus transvaginalinę (2D) sonoskopiją, gimdos ir gimdos priedų sonoskopinių pakitimų nenustatyta. Intrauterininės sąaugos pacientei diagnozuotos atlikus hidrosonografiją, atliktas papildomas tyrimas – HyFoSy (histerosalpingosonoskopija, angl.Hysterosalpingo Foam Sonography). Pacientei buvo atlikta operacija – histeroskopija, kurios metu pašalintos intrauterininės sąaugos. Pooperacinis laikotarpis buvo sklandus. Praėjus dviem mėnesiams po operacijos pacientei nustatytas nėštumas (pacientė konsultuota gydytojo akušerio-ginekologo). Nėštumo eiga buvo sklandi, cezario pjūvio operacijos metu gimė gyvas, vyriškos lyties naujagimis, pagal Apgar balų skalę įvertintas 9/10 balų.Pagrindinis etiologinis veiksnys, lemiantis intrauterininių sąaugų formavimąsi, yra tiesioginis endometriumo pažeidimas. Pateikiamos keturios intrauterininių sąaugų klasifikacijos sistemos, pagal kurias galima numatyti gydymo taktiką ir komplikacijų riziką bei įvertinti pacientės vaisingumo prognozę. Įtariant Ašermano sindromą, rekomenduojama atlikti sonoskopiją arba hidrosonografiją, histerosalpingosonoskopiją arba histerosalpingografiją ir histeroskopiją. Pagrindiniai gydymo etapai: diagnostinė histeroskopija, histeroskopinis intrauterininių sąaugų suardymas ir profilaktinės priemonės (balioninio kateterio, intrauterininės spiralės įvedimas, hialurono rūgšties gelio ar SprayGelʼio vartojimas), pooperacinė hormonų terapija ir, esant indikacijų, pagalbinis apvaisinimas. Kamieninių ląstelių transplantacija į gimdos ertmę, tikėtina, ateityje taps alternatyva chirurginiam gydymui. Nėštumą po Ašermano sindromo gydymo būtina vertinti kaip didelės rizikos nėštumą.
Gorgias’ Argument does not Include Actual Conditionals
Authors: López - Astorga Miguel 
Published: April 2018

[straipsnis ir santrauka anglų kalba, santrauka lietuvių kalba]
It can be thought that Gorgias’ argument on the non-existence consists of three sentences, the first one being an asseveration and the other two being conditionals. However, this paper is intended to show that there is no conditional in the argument, and that the second and third sentences only appear to be so. To do that, a methodology drawn from the framework of the mental models theory is used, which seems to lead to the true logical forms of these last sentences as well.
Transparency, Photography, and the A-Theory of Time
Authors: Tee Sim-Hui 
Published: April 2018

[full article, abstract in English; only abstract in Lithuanian]
Walton’s thesis of transparency of photographs has spurred much dispute among critics. One of the popular objections is spatial agnosticism, an argument that concerns the inertia of egocentric spatial information vis-a-vis a photograph. In this paper, I argue that spatial agnosticism fails. Spatial agnostics claim, for a wrong reason, that a photographic image cannot carry egocentric spatial information. I argue that it is the disjuncture of the photographic world in which the depicted object situated from the space in which the viewer of the photograph resides that renders the photograph spatially agnostic. It is the timeless photographic world rather than the photographic object that renders egocentric spatial information inert. With this new formulation of spatial agnosticism, I propose that spatial agnosticism needs to be coupled with the temporal dimension (the A-theory of time) in the efforts to refute the thesis of transparency of photographs.
Effectiveness of neural mobilization and ultrasound therapy on pain severity in carpal tunnel syndrome
Authors: Alam Mehboob , Khan Muhammad , Ahmed Syed Imran , Ali Syed Shahzad 
Published: April 2018

Objective: To compare the effectiveness of neural mobilization and ultrasound therapy on pain severity in carpal tunnel syndrome (CTS).
Methods: This randomized controlled trial was conducted on 48 CTS patients at the Physiotherapy Department IPM&R, DUHS between 23rd January 2017 and 22nd July 2017. The CTS patients were randomly allocated into 2 equal groups by simple randomization method. Group 1 received neural mobilisation; Group 2 received ultrasound therapy with a predetermined intensity. A total of 12 sessions were given over a period of 4 weeks. Pre and post intervention data were collected from both groups on Visual Analogue Scale (VAS) to measure pain. SPSS version 20 was used for data analysis. Comparisons between post test results of both groups were done by using paired sample t-test with a p-value < 0.05 considered as significant.
Results: It was found that the 79% (19 cases) and 21% (5 cases) in Group 1 (Neural Mobilization), who prior to the treatment had faced moderate and severe pain, respectively, all experienced successful treatment. Indeed, after treatment 100% (24) of the cases only experienced mild pain, indicating successful treatment. For Group 2 (Ultrasound Therapy), 54% (13) and 46% (11) of cases were with moderate and severe pain before treatment; after administering the treatment 20% (5 cases) had mild pain and 80% (19 cases) had moderate pain.
Conclusion: Neural mobilization for median nerve is more beneficial than ultrasound therapy in reducing pain intensity and functional limitations due to CTS.
Interpretation of Do Not Attempt Resuscitation Orders for Children Requiring Anesthesia and Surgery
Authors: Fallat Mary E. , Hardy Courtney ,   SECTION ON SURGERY,   SECTION ON ANESTHESIOLOGY AND PAIN MEDICINE,   COMMITTEE ON BIOETHICS, Meyers Rebecka L. , Besner Gail Ellen , Davidoff Andrew , Heiss Kurt F. , Agarwal Rita , Tobias Joseph , Brown Raeford Eugene , Guzzetta Nina A. , Honkanen Anita , Landrigan-Ossar Mary , Katz Aviva L. , Laventhal Naomi Tricot , Macauley Robert C. , Moon Margaret Rusha , Okun Alexander L. , Opel Douglas J. , Statter Mindy B. 
Published: April 2018

This Clinical Report was reaffirmed November 2024.
This clinical report addresses the topic of pre-existing do not attempt resuscitation or limited resuscitation orders for children and adolescents undergoing anesthesia and surgery. Pertinent considerations for the clinician include the rights of children, decision-making by parents or legally approved representatives, the process of informed consent, and the roles of surgeon and anesthesiologist. A process of re-evaluation of the do not attempt resuscitation orders, called “required reconsideration,” should be incorporated into the process of informed consent for surgery and anesthesia, distinguishing between goal-directed and procedure-directed approaches. The child’s individual needs are best served by allowing the parent or legally approved representative and involved clinicians to consider whether full resuscitation, limitations based on procedures, or limitations based on goals is most appropriate.
Avaliação do crescimento e desenvolvimento infantil na consulta de enfermagem
Authors: Munhoz Gaiva Maria Aparecida , Coutinho Monteschio Caroline , Souza Moreira Mayrene , Marques Salge Ana 
Published: April 2018

Objetivo: Analizar la evaluación del crecimiento y desarrollo infantil en la consulta de enfermería.Metodología: Estudio descriptivo con enfoque cualitativo. Los participantes del estudio fueron cuatro enfermeros que realizaban la consulta de enfermería a los niños de manera programática en unidades de salud de familia en Cuiabá, Mato Grosso, Brasil. La recolección de los datos se llevó a cabo mediante la observación participante de 21 consultas de enfermería entre enero y febrero de 2012. Los datos se analizaron con la técnica de análisis de contenido.Resultados: A partir del análisis de los datos, surgieron las siguientes dos categorías: Evaluación del crecimiento infantil en la consulta de enfermería y Evaluación del desarrollo infantil en la consulta de enfermería. Los enfermeros evaluaron el crecimiento infantil en todas las consultas, utilizando las curvas contenidas en la libreta personal de registro médico del niño. Sin embargo, el desarrollo infantil sólo fue evaluado parcialmente en la mayoría de las consultas observadas.Conclusión: Entre los aspectos más significativos de las consultas de enfermería se destacan la evaluación del crecimiento y desarrollo en todas ellas; y el uso de la libreta personal de registro médico del niño como instrumento de orientación para las madres y como estrategia de seguimiento del crecimiento y desarrollo infantil.
Análise das informações ambientais evidenciadas nos relatórios de sustentabilidade e relatórios anuais sobre efluentes líquidos das empresas brasileiras
Authors: Vogt Mara , Degenhart Larissa , Hein Nelson , Rosa Fabricia Silva da 
Published: April 2018

Resumo: Neste estudo objetivou-se analisar as informações ambientais evidenciadas nos Relatórios de Sustentabilidade (RS) e Relatórios Anuais (RA) sobre efluentes líquidos das empresas brasileiras. Realizou-se pesquisa descritiva, documental e quantitativa. A população da pesquisa compreende as 100 empresas pertencentes ao Índice Brasil 100 e a amostra foi composta por 97 dessas empresas. Foram verificados critérios e subcritérios com diferentes escalas sobre o aspecto efluentes nos RA e RS no período de 2010 a 2013. Calculou-se o peso da informação por meio da entropia e após foi aplicado o método Simple Additive Weighting (SAW) para a elaboração dos rankings e a correlação de Spearman. Em relação aos critérios e subcritérios analisados, o tipo de informação apresentou a maior influência na evidenciação sobre efluentes em ambos os relatórios. No que se refere ao ranking geral sobre as informações ambientais verificadas nos RA, as empresas que mais se destacaram foram a BRF – Brasil Foods e a Duratex. Já referente às informações divulgadas nos RS, as empresas Fibria e BRF – Brasil Foods foram destaque no período analisado. Conclui-se que as empresas brasileiras deveriam divulgar mais informações ambientais sobre efluentes em seus relatórios, visto que muitas destas não apresentaram informações sobre os critérios e subcritérios analisados.Palavras-chave: Evidenciação ambiental. Efluentes líquidos. Empresas brasileiras. Analysis of environmental information evidenced in Sustainability Reporting and Annual Reports on liquid effluent of brazilian Abstract: This study aimed to analyze the environmental information reported through Sustainability Reports (RS) and Annual Reports (RA) on wastewater of Brazilian companies. A descriptive, document and quantitative research. The study population includes 100 companies belonging to the Brazil Index 100 and the sample was composed of 97 of these companies. Criteria and sub-criteria were verified with different scales on the aspect effluents in RA and RS for the period 2010 to 2013. We calculated the weight of the information through the entropy and after we applied the method Simple Additive Weighting (SAW) for the development the rankings and the Spearman correlation. Regarding the analyzed criteria and sub-criteria, the type of information had the highest influence on the disclosure of effluent in both reports. Regarding the overall ranking on environmental information verified in RA, companies that stood out were the BRF – Brazil Foods and Duratex. Already regarding the information disclosed in the RS, the Fibria companies and BRF – Brazil Foods were highlighted during the period. It is concluded that Brazilian companies should disclose more environmental information effluents in their reports, as many of these have not provided information on the criteria and sub-criteria analysis.Keywords: Environmental disclosure. Wastewater. Brazilian companies.
Custo financeiro da estocagem: estudo de caso em indústria de grande porte
Authors: Wernke Rodney , Santos Andrey Pereira dos , Schlickmann Lia , Zanin Antonio 
Published: April 2018

Resumo: Neste artigo objetivou-se a mensuração dos custos financeiros relacionados à estocagem de matérias-primas de uma fábrica de grande porte. Para tanto, foi utilizada metodologia do tipo descritiva, com abordagem qualitativa e o formato de estudo de caso. Quanto aos resultados, no conjunto de 261 matérias-primas estocadas (que superava R$ 5,3 milhões) foram aplicados os procedimentos detalhados no texto que proporcionaram informações gerenciais acerca do valor elevado dos estoques excedentes (R$ 1.029.913,26), da existência de insumos com prazos de estocagem extensos e de custos financeiros expressivos (superiores a R$ 170 mil) pela manutenção de estoque com tais características. Além disso, foi possível determinar os produtos mais problemáticos e o desempenho por grupos de matérias-primas, permitindo a comparação entre essas modalidades de segregação. Por último, foram elencadas algumas limitações do estudo e recomendados temas para futuras pesquisas.Palavras-chave: Custo financeiro. Estoque. Estudo de caso. Financial cost of storage: a case study in a large industry Abstract: The article aimed at the measurement of financial costs related to the storage of raw materials of a large factory. For that, a descriptive methodology was used, with a qualitative approach and the case study format. As to the results, the procedures detailed in the text that provided managerial information about the high value of surplus inventories (R$ 1.029.913, 26), the existence of inputs with long storage periods and significant financial costs (over R$ 170 thousand) for the maintenance of inventory with such characteristics. In addition, it was possible to determine the most problematic products and performance by groups of raw materials, allowing a comparison between these segregation modalities. Finally, some limitations of the study and recommended topics for future research were listed.Keywords: Financial cost. Stock. Case study.
INTEGRATION OF PROJECT MANAGEMENT INTO THE INVESTMENT STRATEGY OF AN INNOVATIVE CLUSTER (THE CASE OF INNOKAM)
Authors: Майоров C. , Mayorov S. 
Published: April 2018

<p>With reference to the activity of the Kama Innovation Cluster "Innokam", the paper considers some issues of the integration of project management mechanisms into the investment strategy of the cluster structures. Such a strategy implemented by Innocam's structures in the context of open innovation encompasses a set of innovative projects, including the creation of engineering centers for the development of flexible production systems, the design of high technologies, new generation robotic complexes, etc. The study describes some features of an innovative cluster functioning in the environment of open innovations, which is characterized by a high level of uncertainty. The article introduces the business model of the strategic partnership of "Innokam" structures, which is focused on the environment of open innovations. Tools for strategic analysis<br />have been developed, the results of which are used by Innokam structures when creating<br />an array of input data necessary for the design of a project ma nagement strategy. The research explores the mechanism and principles of the development of the project management strategy in relation to the investment activities of the Innocam structures. Taking into account the specifics of the functioning of these structures, the scenario planning methodology has been modernized and a tool for selecting the best variant of the project management strategy has been proposed. The paper includes proposals on the construction of a multi-level management system, taking into account the specific features of Innokam’s investment activities. With respect<br />to each level of management, criteria are given for assessing the effectiveness of the system. The research has justified the use of controlling that fulfills the role of feedback in the management system, which allows one to evaluate the effectiveness of the project strategy implemented by Innocam's structures</p>
THE PROBLEM OF TERRITORIAL POPULATION CONCENTRATION AND THE ONE-INDUSTRY TOWNS IN THE NORTHERN REGION (THE REPUBLIC OF SAKHA (YAKUTIA)
Authors: Мостахова Т. , Mostakhova T. 
Published: April 2018

<p>The resettlement of the population appears to be a significant factor in the sustainable development of the territory. The imbalances in spatial development that have been forming during a certain period of time concern mostly the imbalances between the center and the periphery, urban and rural settlements. This disproportion draws scientific attention to the processes of population concentration and the prospects for their development. Over the past decades, the main trend in resettlement has been the flow of the population<br />to the center and the negative peripheral dynamics. The deep transformational changes in Russia, which coincided with significant demographic changes, resulted in an increasing dichotomy between the focal point and the province. In the Northern and Arctic regions, this tendency is reflected in a reduction in the number of settlements, both urban and rural. The dilution of the settlement network, together with the deepening of the territorial population concentration, lead to even greater depersonalization on the territory. Rural settlement downturn has been accompanied<br />by certain changes in the character of urban settlements, where a significant proportion belongs to single-industry towns. The instability of the city-forming base poses a threat to the demographic potential of single-industry towns. Northern ingle-industry towns owe their existence to the specifics of regional<br />development that has always been focused on the extraction of strategically important</p>
MONO-CITIES IN THE STRUCTURE OF THE REGIONAL CLUSTER: CONDITIONS OF MUTUAL SUPPORT BY POSITIVE EFFECTS
Authors: Акинфеева Е. , Akinfeeva E. , Ерзнкян Б. , Yerznkyan B. 
Published: April 2018

<p>Economic development of the country depends on the economic development of the regions, and also largely on the development of mono-profile municipal entities on the territory of these regions – single-industry towns, which is largely determined by the ability of mono-cities to diversify their economic activities. One of the ways<br />to implement this (without hindering the development of the profile industries) is the application of a cluster approach to mono-cities, with their consideration in the role of cluster elements operating in the region. Such an approach will allow coordinating the regional policy with respect to its proportional development with the strategic policy of municipalities. The report reveals the essence of the concept of "mono-cities", reflects the main problems of the development of such entities, and studies the cluster approach as a means of improving single-industry towns and regions in general. In particular, the paper features the conditions under which the cluster members can receive positive effects that would be external to mono-cities, as well as the ways mono-cities themselves can obtain a part of the synergetic effect from the activity of the regional cluster.</p>