bluuebunny/crossref_metadata_2025_split huggingface dataset:
“We are all republicans”: Political Articulation and the Production of Nationhood in France's Face Veil Debate
Authors: Laxer Emily 
Published: October 2018

AbstractIn July 2010, following a year-long nationwide debate over Islamic veiling, the French government passed a law prohibiting facial coverings in all public spaces. Prior research attributes this and other restrictive laws to France's republican secular tradition. This article takes a different approach. Building on literature that sees electoral politics as a site for articulating, rather than merely reflecting, social identities, I argue that the 2010 ban arose in significant part out of political parties’ struggles to demarcate the boundaries of legitimate politics in the face of an ultra-right electoral threat. Specifically, I show that in seeking to prevent the ultra-right National Front party from monopolizing the religious signs issue, France's major right and left parties agreed to portray republicanism as requiring the exclusion of face veiling from public space. Because it was forged in conflict, however, the consensus thus generated is highly fractured and unstable. It conceals ongoing conflict, both between and within political parties, over the precise meaning(s) of French republican nationhood. The findings thus underscore the relationship between boundary-drawing in the political sphere and the process of demarcating the cultural and political boundaries of nationhood in contexts of immigrant diversity.
Rustic Reich: The Local Meanings of (Trans)National Socialism among Paraguay's Mennonite Colonies
Authors: Eicher John 
Published: October 2018

AbstractThis article compares two German-speaking Mennonite colonies in Paraguay and their encounters with Nazism during the 1930s. It focuses on their understandings of the Nazi bid for transnationalvölkischunity. Latin America presents a unique context for studying the Nazis’ relationship to German-speakers abroad because it held the allure of being the last prospect for German cultural and economic expansion, but was simultaneously impossible for the German state to invade. The Menno Colony was made up of voluntary migrants from Canada who arrived in Paraguay in the 1920s. The Fernheim Colony was composed of refugees from the Soviet Union who settled alongside the Menno Colony in the 1930s. Both groups shared a history in nineteenth-century Russia as well as a common faith and culture. Nevertheless, they developed radically different opinions aboutvölkischnationalism. The Menno Colony's communal understanding of Germanness madevölkischpropaganda about Hitler's “New Germany” unappealing to their local sensibilities. They rejected all forms of nationalism as worldly attempts to thwart their cultural-religious isolationism. The refugees of Fernheim Colony, by contrast, shared little communal unity since they originated from diverse settlements across the Soviet Union. They viewed Germanness as a potential bridge to an imagined German homeland and believed that the highest goal ofvölkischunity was to promote communal unity. Resembling other German-speaking communities in Latin America, the two colonies—which seemed identical to Nazi observers—held vastly different interpretations ofvölkischnationalism at the height of the Nazi bid to establish transnational German unity in Latin America.
Integration and Identities: The Effects of Time, Migrant Networks, and Political Crises on Germans in the United States
Authors: Krawatzek Félix , Sasse Gwendolyn 
Published: October 2018

AbstractThis article offers the first large-scale analysis of the interlinked dynamics of integration and belonging based on perceptions of “ordinary” German-speaking migrants in the United States in the nineteenth and twentieth centuries. Our analysis draws on a corpus of over a thousand letters from the North American Letter Collection held at the Forschungsbibliothek Gotha in Germany. Through computer-assisted text analysis, framed by research on transnationalism and immigrant integration, we explore patterns in integration and identities over time. We show how the migrants continuously redefine their identities vis-à-vis their homeland and the host society, and their letters thereby shape the image of the United States and the homeland for their recipients. Our analysis establishes more comprehensively than have previous historical and social science studies that integration into a host society is a non-linear process. Immigrant identities are influenced less by the time they have spent in the receiving country than by critical political events that affect both the country of origin and that of destination. Such events can reactivate migrant's identifications with their homeland. Immigrant networks filter this dual process in that they can facilitate migrants’ integration while also reminding them of people and places left behind.
The effects of systemic steroid therapy on macrophage migration inhibitory factor concentrations in patients with nasal polyps
Authors: Ekinci A 
Published: October 2018

AbstractObjectivesThis study aimed to compare serum macrophage migration inhibitory factor concentrations before and after oral steroid therapy in nasal polyps patients, and determine whether there is a difference between pre-treatment macrophage migration inhibitory factor concentrations and healthy individuals.MethodsThe study included 24 patients with nasal polyps and 25 healthy individuals. The patient group received 1 mg/kg oral steroid.ResultsThe mean macrophage migration inhibitory factor concentration before oral steroid therapy was 3889.79 pg/ml in the patient group and 2334.52 pg/ml in the control group. Macrophage migration inhibitory factor concentrations were statistically significantly higher in the pre-oral steroid therapy patient group than in the control group (p= 0.017). The mean pre- and post-oral steroid therapy serum macrophage migration inhibitory factor concentrations were 3889.79 pg/ml and 2451.25 pg/ml, respectively. The reduction in macrophage migration inhibitory factor concentrations was statistically significant (p= 0.010).ConclusionThese findings suggest that concentrations of macrophage migration inhibitory factor may play a role in the pathogenesis of nasal polyps.
Quantity-based reasoning in the broader autism phenotype: A web-based study
Authors: VAN TIEL BOB , KISSINE MIKHAIL 
Published: October 2018

ABSTRACTWe conducted a web-based study investigating whether the probability of deriving four types of pragmatic inferences depends on the degree to which one has traits associated with the autism spectrum, as measured by the autism spectrum quotient test (Baron-Cohen, Wheelwright, Skinner, Martin, & Clubley, 2001). In line with previous research, we show that, independently of their autism spectrum quotient, participants are likely to derive those pragmatic inferences that can be derived by reasoning solely about alternatives that the speaker could have used. However, if the derivation of the pragmatic inference draws upon more complex counterfactual reasoning about what the speaker could have said, the probability that it is derived decreases significantly with one’s autism quotient. We discuss the consequences for theories of pragmatics in autism and for linguistic theorizing in general.
Prospective Evaluation of Point-of-Care Ultrasound at a Remote, Multi-Day Music Festival
Authors: Prager Ross , Sedgwick Colin , Lund Adam , Kim Daniel , Ho Ben , Stachura Maja , Gutman Samuel 
Published: October 2018

AbstractIntroductionPoint-of-Care Ultrasound (POCUS) has become an important diagnostic tool for hospital-based clinicians. This study assesses the role of POCUS at Pemberton Music Festival 2016 (Pemberton, British Columbia [BC], Canada), a remote mass gathering where physicians face limited resources, complex disposition decisions, and a dynamic clinical environment.ObjectivesThis study prospectively evaluated the impact of POCUS on patient diagnosis, management, and disposition based on the self-report of the study physicians. The authors hypothesized that having ultrasound available for use would aid in diagnostic and management decisions and would reduce the need to transfer patients off-site to other health care facilities, reducing impact on the acute health services in the host community.MethodsA handheld ultrasound was available for use by physicians in the main medical tent. All participating physicians self-reported their training and comfort using POCUS. After each POCUS scan, physicians completed a survey and recorded the indication for use, scans performed, and impact on patient diagnosis, management, and disposition.ResultsIn total, POCUS was used on 28 of the 686 patients treated in the main medical tent; POCUS was reported to narrow the differential diagnosis in 64% of cases and altered the working diagnosis in 21% of cases. Its use changed the management plan in 39% of patients. Its use was reported to reduce the burden on broader health care resource utilization in 46% of cases and prevented ambulance transport off-site in 32% of cases (nine cases in total). This corresponded to an absolute risk reduction of 1.3% for the percentage of patients transferred to hospital (PPTH; relative risk reduction of 53%).Conclusion:Physicians reported that POCUS improved the diagnosis, management, and disposition of select patients at a remote, multi-day music festival. Also, POCUS reduced ambulance transfers off-site and reduced the perceived burden on broader health care utilization.PragerR, SedgwickC, LundA, KimD, HoB, StachuraM, GutmanS. Prospective evaluation of point-of-care ultrasound at a remote, multi-day music festival. Prehosp Disaster Med. 2018;33(5):484–489.
Insights on the Japanese Subduction Megathrust Properties From Depth and Lateral Variability of Observed Ground Motions
Authors: Piña‐Valdés J. , Socquet A. , Cotton F. 
Published: October 2018

AbstractTwo ground motion prediction equation models for subduction zones have been tested using a public ground motion database of the KiK‐net records obtained by automated processing protocols (Dawood et al., 2016, https://doi.org/10.1193/071214EQS106). The database contains records of more than 700 interface earthquakes that occurred on the Japan subduction between 1998 and 2012. The Zhao et al. (2006, https://doi.org/10.1785/0120050122) ground motion prediction equation was shown to be the best suited model for the region. It was then used as backbone to analyze the variability of ground motion records. The residuals between observed and predicted ground motions have been analyzed to study the spatial variation of the earthquakes' ground motion frequency content on the Japan megathrust. This analysis revealed a depth dependency of generated ground motions consistent with the downdip segmentation proposed for subduction interfaces (Lay et al., 2012, https://doi.org/10.1029/2011JB009133), a regional ground motion dependency that may be related with lateral variations of the mechanical properties of the subduction interface and a high‐frequency radiations drop in the earthquake sequence that preceded the Tohoku‐Oki earthquake Mw 9.0. The regional ground motion dependency suggests the existence of different domains along trench of the Japan subduction megathrust that control the ground motions and the wave radiation patterns of interface earthquakes. The location of their boundaries is consistent with the extension of the rupture of the 2011 Tohoku‐Oki earthquake, with pre‐Tohoku interseismic coupling, and with the free air gravity anomalies.
Coupled Numerical Modeling of Gas Hydrate‐Bearing Sediments: From Laboratory to Field‐Scale Analyses
Authors: Sánchez Marcelo , Santamarina Carlos , Teymouri Mehdi , Gai Xuerui 
Published: October 2018

AbstractMethane hydrates are ice‐like compounds made of gas methane and water. Hydrates are stable under low‐temperature and high‐pressure conditions constraining their occurrence in sediments to marine and permafrost settings. A shift from the stability condition triggers an endothermic hydrate dissociation with the associated release of gas and water, impacting (among others) on sediment pore pressure, temperature, and deformations. Therefore, the behavior of hydrate‐bearing sediments (HBS) is controlled by strongly coupled thermo‐hydro‐chemo‐mechanical actions. The analysis of available data from past field and laboratory experiments and the optimization of future field production studies require a formal and robust numerical framework able to capture the complex behavior of this type of soil. In this paper we used a fully coupled thermo‐hydro‐mechanical framework to study different problems involving HBS, from laboratory experiments involving natural hydrate samples to gas production tests. We also develop an analytical solution for the case of gas production via radial depressurization from a confined HBS reservoir. The analyses show the complexity of the thermo‐hydro‐mechanical phenomena associated with this type of system and contribute to better understand the behavior of HBS.
Geochemical Characterization of Two Ferruginous Meromictic Lakes in the Upper Midwest, USA
Authors: Lambrecht Nicholas , Wittkop Chad , Katsev Sergei , Fakhraee Mojtaba , Swanner Elizabeth D. 
Published: October 2018

AbstractTo elucidate the role of (bio)geochemical processes that fueled iron and carbon cycling in early Earth oceans, modern environments with similar geochemical conditions are needed. As the range of chemical, physical, and biological attributes of the Precambrian oceans must have varied in time and space, lakes of different compositions are useful to ask and answer different questions. Tropical Lake Matano (Indonesia), the largest known ferruginous lake, and Lake Pavin (France), a meromictic crater lake, are the two best studied Precambrian ocean analogs. Here we present seasonal geochemical data from two glacially formed temperate ferruginous lakes: Brownie Lake (MN) and Canyon Lake (MI) in the Upper Midwest, USA. The results of seasonal monitoring over multiple years indicate that (1) each lake is meromictic with a dense, anoxic monimolimnion, which is separated from the less dense, oxic mixolimnion by a sharp chemocline; (2) below this chemocline are ferruginous waters, with maximum dissolved iron concentrations >1 mM; (3) meromixis in Brownie Lake is largely anthropogenic, whereas in Canyon Lake it is natural; (4) the shallow chemocline of Brownie Lake and high phosphorus reservoir make it an ideal analog to study anoxygenic photosynthesis, elemental ratios, and mineralogy; and (5) a deep penetrating suboxic zone in Canyon Lake may support future studies of suboxic microbial activity or mineral transformation.
Powerful turbidity currents driven by dense basal layers
Authors: Paull Charles K. , Talling Peter J. , Maier Katherine L. , Parsons Daniel , Xu Jingping , Caress David W. , Gwiazda Roberto , Lundsten Eve M. , Anderson Krystle , Barry James P. , Chaffey Mark , O’Reilly Tom , Rosenberger Kurt J. , Gales Jenny A. , Kieft Brian , McGann Mary , Simmons Steve M. , McCann Mike , Sumner Esther J. , Clare Michael A. , Cartigny Matthieu J. 
Published: October 2018

AbstractSeafloor sediment flows (turbidity currents) are among the volumetrically most important yet least documented sediment transport processes on Earth. A scarcity of direct observations means that basic characteristics, such as whether flows are entirely dilute or driven by a dense basal layer, remain equivocal. Here we present the most detailed direct observations yet from oceanic turbidity currents. These powerful events in Monterey Canyon have frontal speeds of up to 7.2 m s−1, and carry heavy (800 kg) objects at speeds of ≥4 m s−1. We infer they consist of fast and dense near-bed layers, caused by remobilization of the seafloor, overlain by dilute clouds that outrun the dense layer. Seabed remobilization probably results from disturbance and liquefaction of loose-packed canyon-floor sand. Surprisingly, not all flows correlate with major perturbations such as storms, floods or earthquakes. We therefore provide a new view of sediment transport through submarine canyons into the deep-sea.
Bone protection by inhibition of microRNA-182
Authors: Inoue Kazuki , Deng Zhonghao , Chen Yufan , Giannopoulou Eugenia , Xu Ren , Gong Shiaoching , Greenblatt Matthew B. , Mangala Lingegowda S. , Lopez-Berestein Gabriel , Kirsch David G. , Sood Anil K. , Zhao Liang , Zhao Baohong 
Published: October 2018

AbstractTargeting microRNAs recently shows significant therapeutic promise; however, such progress is underdeveloped in treatment of skeletal diseases with osteolysis, such as osteoporosis and rheumatoid arthritis (RA). Here, we identified miR-182 as a key osteoclastogenic regulator in bone homeostasis and diseases. Myeloid-specific deletion of miR-182 protects mice against excessive osteoclastogenesis and bone resorption in disease models of ovariectomy-induced osteoporosis and inflammatory arthritis. Pharmacological treatment of these diseases with miR-182 inhibitors completely suppresses pathologic bone erosion. Mechanistically, we identify protein kinase double-stranded RNA-dependent (PKR) as a new and essential miR-182 target that is a novel inhibitor of osteoclastogenesis via regulation of the endogenous interferon (IFN)-β-mediated autocrine feedback loop. The expression levels of miR-182, PKR, and IFN-β are altered in RA and are significantly correlated with the osteoclastogenic capacity of RA monocytes. Our findings reveal a previously unrecognized regulatory network mediated by miR-182-PKR-IFN-β axis in osteoclastogenesis, and highlight the therapeutic implications of miR-182 inhibition in osteoprotection.
A luminous blue kilonova and an off-axis jet from a compact binary merger at z = 0.1341
Authors: Troja E. , Ryan G. , Piro L. , van Eerten H. , Cenko S. B. , Yoon Y. , Lee S.-K. , Im M. , Sakamoto T. , Gatkine P. , Kutyrev A. , Veilleux S. 
Published: October 2018

AbstractThe recent discovery of a gamma-ray burst (GRB) coincident with the gravitational-wave (GW) event GW170817 revealed the existence of a population of low-luminosity short duration gamma-ray transients produced by neutron star mergers in the nearby Universe. These events could be routinely detected by existing gamma-ray monitors, yet previous observations failed to identify them without the aid of GW triggers. Here we show that GRB150101B is an analogue of GRB170817A located at a cosmological distance. GRB150101B is a faint short burst characterized by a bright optical counterpart and a long-lived X-ray afterglow. These properties are unusual for standard short GRBs and are instead consistent with an explosion viewed off-axis: the optical light is produced by a luminous kilonova, while the observed X-rays trace the GRB afterglow viewed at an angle of ~13°. Our findings suggest that these properties could be common among future electromagnetic counterparts of GW sources.
Graphene-enabled and directed nanomaterial placement from solution for large-scale device integration
Authors: Engel Michael , Farmer Damon B. , Azpiroz Jaione Tirapu , Seo Jung-Woo T. , Kang Joohoon , Avouris Phaedon , Hersam Mark C. , Krupke Ralph , Steiner Mathias 
Published: October 2018

AbstractDirected placement of solution-based nanomaterials at predefined locations with nanoscale precision limits bottom-up integration in semiconductor process technology. We report a method for electric-field-assisted placement of nanomaterials from solution by means of large-scale graphene layers featuring nanoscale deposition sites. The structured graphene layers are prepared via either transfer or synthesis on standard substrates, and then are removed once nanomaterial deposition is completed, yielding material assemblies with nanoscale resolution that cover surface areas >1 mm2. In order to demonstrate the broad applicability, we have assembled representative zero-dimensional, one-dimensional, and two-dimensional semiconductors at predefined substrate locations and integrated them into nanoelectronic devices. Ultimately, this method opens a route to bottom-up integration of nanomaterials for industry-scale applications.
Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration
Authors: Meliani Amine , Boisgerault Florence , Hardet Romain , Marmier Solenne , Collaud Fanny , Ronzitti Giuseppe , Leborgne Christian , Costa Verdera Helena , Simon Sola Marcelo , Charles Severine , Vignaud Alban , van Wittenberghe Laetitia , Manni Giorgia , Christophe Olivier , Fallarino Francesca , Roy Christopher , Michaud Alicia , Ilyinskii Petr , Kishimoto Takashi Kei , Mingozzi Federico 
Published: October 2018

AbstractGene therapy mediated by recombinant adeno-associated virus (AAV) vectors is a promising treatment for systemic monogenic diseases. However, vector immunogenicity represents a major limitation to gene transfer with AAV vectors, particularly for vector re-administration. Here, we demonstrate that synthetic vaccine particles encapsulating rapamycin (SVP[Rapa]), co-administered with AAV vectors, prevents the induction of anti-capsid humoral and cell-mediated responses. This allows successful vector re-administration in mice and nonhuman primates. SVP[Rapa] dosed with AAV vectors reduces B and T cell activation in an antigen-selective manner, inhibits CD8+ T cell infiltration in the liver, and efficiently blocks memory T cell responses. SVP[Rapa] immunomodulatory effects can be transferred from treated to naive mice by adoptive transfer of splenocytes, and is inhibited by depletion of CD25+ T cells, suggesting a role for regulatory T cells. Co-administration of SVP[Rapa] with AAV vector represents a powerful strategy to modulate vector immunogenicity and enable effective vector re-administration.
Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex
Authors: Obermayer Joshua , Heistek Tim S. , Kerkhofs Amber , Goriounova Natalia A. , Kroon Tim , Baayen Johannes C. , Idema Sander , Testa-Silva Guilherme , Couey Jonathan J. , Mansvelder Huibert D. 
Published: October 2018

AbstractA variety of inhibitory pathways encompassing different interneuron types shape activity of neocortical pyramidal neurons. While basket cells (BCs) mediate fast lateral inhibition between pyramidal neurons, Somatostatin-positive Martinotti cells (MCs) mediate a delayed form of lateral inhibition. Neocortical circuits are under control of acetylcholine, which is crucial for cortical function and cognition. Acetylcholine modulates MC firing, however, precisely how cholinergic inputs affect cortical lateral inhibition is not known. Here, we find that cholinergic inputs selectively augment and speed up lateral inhibition between pyramidal neurons mediated by MCs, but not by BCs. Optogenetically activated cholinergic inputs depolarize MCs through activation of ß2 subunit-containing nicotinic AChRs, not muscarinic AChRs, without affecting glutamatergic inputs to MCs. We find that these mechanisms are conserved in human neocortex. Cholinergic inputs thus enable cortical pyramidal neurons to recruit more MCs, and can thereby dynamically highlight specific circuit motifs, favoring MC-mediated pathways over BC-mediated pathways.