bluuebunny/crossref_metadata_2025_split huggingface dataset:
DENGELİ PUAN KARTI VE RİSK YÖNETİMİ: ENTEGRASYON İÇİN ALTERNATİF YAKLAŞIMLARIN İNCELENMESİ
Authors: ÖZER Gökhan , ÇAM İlhan 
Published: January 2019

İşletmeler,
hissedar değerlerinin korunmasını ve güçlendirilmesini sağlamak için dengeli
puan kartı (DPK) ile değer yaratma sürecini kontrol ederlerken, risk yönetimi
ile de değer kaybının önlenmesini sağlamaktadırlar. Her iki yönetimsel sürecin
birbirlerinin eksikliklerini gidererek daha etkin bir araç olmalarını sağlamak için,
biçimsel bir şekilde entegre edilerek yürütülmeleri gerektiğine dair çeşitli araştırmacılar
tarafından tavsiyelerde bulunulmuş ve çeşitli kavramsal yöntemler geliştirilmiştir.
Ancak işletmeler için, önerilen bu yöntemler arasından hangisinin daha uygun
olacağının ayrıntılı bir şekilde incelenmesi ve araştırmacılar için ise ileride
geliştirilecek yeni kavramsal yöntemlere ışık tutacak önerilerde bulunulması
gerekmektedir. Bu sebeple bu çalışmada, ilgili literatürdeki araştırma
eksikliğinin giderilmesine katkı sağlamak amacıyla risk yönetimini DPK’ye
entegre eden alternatif yaklaşımlar incelenmiş ve bu yaklaşımların birbirleri
üzerindeki artı ve eksilerinin neler olduğu tartışılmıştır. Yapılan incelemeler
doğrultusunda en iyi alternatif yöntemin, stratejik hedeflere bağlı birleşik
bir risk faktörünün her bir boyut için geliştirilmesiyle ve ayrıca strateji
haritasında yer alan finansal boyut içerisine üçüncü bir strateji teması olarak
risk yönetimi stratejisinin eklenmesiyle elde edileceği düşünülmektedir.
Crespo, M.B., Martínez-Azorín, M. &amp; Mavrodiev, E.V. (2018) Notes on taxonomy and nomenclature of juno irises (Juno, Iridaceae). Phytotaxa 376 (5): 185–200.
Authors: CRESPO MANUEL B. , MARTÍNEZ-AZORÍN MARIO , MAVRODIEV EVGENY V. 
Published: January 2019

In a recent publication on nomenclature and taxonomy of the genus Juno, we have established several new combinations for irises, including Iris koyuncui Fırat. When stating the intended new combination in Juno for the latter name, a partially wrong citation of its basionym was made. Although the publication year, page number and holotype data were correctly and fully indicated for that basionym, the Fırat’s paper referenced in the literature list to justifiy the basionym citation was indeed a different one in the same journal, which however concerned another taxon from the same area, Iris zagrica Mathew & Zarrei subsp. hakkariensis Fırat, and not the basionym of Iris koyuncui. In the present contribution, evidence is shown to regard the incorrect citation of the place of publication of the basionym as a correctable error not affecting valid publication of the combination, which is fixed here to be cited as J. koyuncui (Fırat) M.B.Crespo, Mart.-Azorín & Mavrodiev.
World Religions and Human Capital Investment: The Case of Primary Education
Authors: Feldmann Horst 
Published: January 2019

Using data on 150 countries, this article studies if and how the largest world religions have affected the extent of primary education at the national level over the period 1972–2010. Although primary education has been compulsory in most countries for at least several decades, the regression results suggest that these religions have indeed still been able to exert an influence on this type of education. Specifically, whereas Protestantism and Catholicism had a positive effect on the male primary enrolment rate, Hinduism and Buddhism had a negative effect on the female primary enrolment rate. Islam had a negative effect on both. While the magnitude of the estimated effects is small for boys, it is more substantial for girls, particularly the negative effect of Islam. The estimates are robust to endogeneity of all five religion adherence variables. They are also robust to numerous controls and variations in specification. JEL: I21, N30, O15, Z12
Evaluation of CT enterography findings for endoscopic complete remission after anti-TNF-α therapy in patients with Crohn’s disease
Authors: Kim Jieun , Kim Seung Ho , Kim Tae Oh 
Published: January 2019

Background Unnecessary prolonged treatment with biologic agents for Crohn’s disease (CD) patients with endoscopic complete remission (CR) might increase the opportunistic infections. Purpose To evaluate computed tomography enterography (CTE) findings obtained on CD patients achieving endoscopic CR after anti-tumor necrosis factor (TNF)-α therapy. Material and Methods Thirty-six consecutive patients with CD who had received anti-TNF- α therapy and undergone pre-and post-therapy CTE and ileocolonoscopy were initially enrolled. CTE was performed with a standard-dose enteric-phase scan. Eleven patients were excluded due to a mismatch of follow-up intervals or a long interval (>2 weeks) between CTE and ileocolonoscopy; additionally, five patients were excluded due to surgical intervention during the follow-up period. Therefore, 20 patients finally were analyzed. Two blinded readers evaluated the pre-and post-therapy CTE images by consensus for active inflammation, i.e. mural hyperenhancement, mural thickening (thickness > 3 mm), mural stratification, and increased peri-enteric fat attenuation in the rectum, colon, and terminal ileum. Endoscopic CR indicated mucosal healing identified by ileocolonoscopy and served as the reference standard. Results Nine patients with 16 bowel segments showed endoscopic CR. Ten of those segments showed residual abnormalities including mild mural hyperenhancement (9/16, P = 0.03), mild mural thickening (6/16, P < 0.001), and both findings (5/16, P < 0.001) on post-therapy CTE. The non-CR group (11 patients; 17 bowel segments) showed a higher concordance rate with post-therapy CTE (88%, 15/17) than did the CR group (38%, 6/16) ( P = 0.004). Conclusion Residual mild mural hyperenhancement and mild mural thickening were seen on post-therapy CTE in over half of the bowel segments showing endoscopic CR.
Terrestrial laser scanning and structure-from-motion photogrammetry concordance analysis for describing the surface layer of gravel beds
Authors: Neverman Andrew J , Fuller Ian C , Procter Jon N , Death Russell G 
Published: January 2019

Terrestrial laser scanning (TLS) and structure-from-motion photogrammetry (SfMp) offer rapid, non-invasive surveying of in situ gravels. Numerous studies have used the point clouds derived from TLS or SfMp to quantify surface layer characteristics, but direct comparison of the methods for grain-scale analysis has received relatively little attention to date. Comparing equivalent products of different data capture methods is critical as differences in errors and sampling biases between the two methods may produce different outputs, effecting further analysis. The sampling biases and errors related to SfMp and TLS lead to differences in the point clouds produced by each method. The metrics derived from the point clouds are therefore likely to differ, potentially leading to different inputs for entrainment threshold models, different trends in surface layer development being identified and different trajectories for physical processes and habitat quality being predicted. This paper provides a direct comparison between TLS and SfMp surveys of an exposed gravel bar for three different survey periods following inundation and reworking of the bar surface during high flow events. The point clouds derived from the two methods are used to describe changes in the character of the surface layer between bar inundation events, and comparisons are made with descriptions derived from conventional pebble counts. The results found differences in the metrics derived using each method do exist, but the grid resolution used to detrend the surfaces and identify spatial variations in surface layer characteristics had a greater impact than survey method. Further research is required to understand the significance of these variations for quantifying surface texture and structure and for predicting entrainment thresholds and transport rates.
Feasibility and Acceptability of Metformin to Augment Low Milk Supply: A Pilot Randomized Controlled Trial
Authors: Nommsen-Rivers Laurie , Thompson Amy , Riddle Sarah , Ward Laura , Wagner Erin , King Eileen 
Published: January 2019

Background: Metformin improves insulin action, but feasibility in treating low milk supply is unknown. Research aim: To determine the feasibility of a metformin- versus-placebo definitive randomized clinical trial in women with low milk production and signs of insulin resistance. Methods: Pilot trial criteria included: Mother 1–8 weeks postpartum (ideally 1–2 weeks), low milk production, and ≥1 insulin resistance sign; and singleton, healthy, term infant. Eligible mothers were randomly assigned 2:1 (metformin:placebo) and instructed in frequent milk removal for 28 days with option to stop at 14 days. Results: From 02/2015 through 06/2016, we screened 114 women, completed baseline assessments on 46, and trialed 15 (median, 36 days postpartum). Comparing metformin-assigned ( n = 10) to placebo ( n = 5), 70% versus 80% continued to day 28; peak median change in milk output was +8 versus –58 mL/24 hr ( p = .31) and 80% peaked at Day 14 for both groups; 0% versus 20% desired to continue assigned drug after study completion; 44% versus 0% reported nausea/vomiting. Post-hoc, median peak change in milk output was +22 (metformin completers, n = 8) versus –58 mL/24 hr (placebo + non-completers, n = 7, p = .07). At baseline assessment, median milk production was significantly lower in those with ( n = 31), versus those without ( n = 15) signs of insulin resistance ( p = .002). Conclusions: Although results trend toward hypothesized direction, trial feasibility concerns include late enrollment and only 20% of metformin-assigned participants sustaining improved milk output to Day 28, with none perceiving metformin worthwhile. Better tools are needed to identify and treat metabolically-driven low milk production. Registered at ClinicalTrials.gov (NCT02179788) on 02/JUL/2014.
N-acetylcysteine for adults with acute respiratory distress syndrome: A meta-analysis of randomized controlled trials
Authors: Lu Xin , Ma Yong , He Jianqiang , Li Yi , Zhu Huadong , Yu Xuezhong 
Published: January 2019

Background: Acute respiratory distress syndrome is regarded as a formidable clinical challenge due to its high prevalence and mortality. The treatment of acute respiratory distress syndrome is very complex and difficult. As an adjuvant therapy, the antioxidant N-acetylcysteine has been investigated for several years but the benefit is controversial. Objectives: We performed the systematic review and meta-analysis of randomized controlled trials to evaluate the efficacy of N-acetylcysteine on patients with acute respiratory distress syndrome. Methods: We searched PubMed, CENTRAL, and CBM databases. Randomized controlled trials comparing the effects of N-acetylcysteine and control were included. Overall mortality was the primary outcome; length of intensive care unit stay, duration of mechanical ventilation, glutathione levels, and PaO2/FiO2 were the secondary outcomes. Results: Eight trials with a total of 289 patients were included. Compared to the control group, the N-acetylcysteine group did not lower the overall mortality (risk ratio: 0.83; 95% confidence interval: 0.62 to 1.11; P = 0.21; I2 = 0%). However, N-acetylcysteine significantly shortened intensive care unit stay in the random-effects model (mean difference: –4.47 days; 95% confidence interval: –8.79 to −0.14; P = 0.04; I2 = 46%). Due to substantial heterogeneity and limited number of studies, the data of duration of mechanical ventilation, glutathione levels, and PaO2/FiO2 could not be pooled in the meta-analysis. Conclusion: N-acetylcysteine is ineffective in reducing mortality but beneficial for intensive care unit stay. Nonetheless, the effectiveness of N-acetylcysteine for acute respiratory distress syndrome is limited and further research is required before strong recommendations can be made.
Pain Trajectory After Ankle Surgeries for Osteoarthritis
Authors: Guichard Leah , Vanhaesebrouck Alexis , Fletcher Dominique , Stiglitz Yves , Rouquette Alexandra , Martinez Valeria 
Published: January 2019

Background: The pain trajectory after ankle surgeries for osteoarthritis is relevant to describe. The purpose of this prospective study was to describe pain after ankle surgery and explore the link between perioperative factors and the development of postoperative pain. Methods: Duration, severity, type of preoperative pain, psychological distress, opioid consumption, and type of surgery were evaluated in 49 patients who were followed for 18 months. Acute postoperative pain in the first 10 days after surgery was modeled by a pain trajectory. Univariate analysis was conducted to identify predictors of acute pain trajectory and chronic pain. Results: Eighty-seven percent of patients had preoperative chronic pain, 34% had a high postoperative pain trajectory, 44% of whom reported chronic pain at 18 months. The patients who developed a high acute pain trajectory had higher preoperative opioid consumption (50% vs 19.4%, P = .04), a higher incidence of preoperative neuropathic pain (68.8% vs 32.3%, P = .02), a higher brief pain inventory score (51.5 vs 34, P = .01), and a higher psychological distress score (8 vs 3, P = .002). The patients who developed chronic pain had a higher brief pain inventory score (42 vs 33, P = .04), a higher psychological distress score (6 vs 4, P = .04), and a higher preoperative pain intensity (8 vs 6, P = .008). No association was found between the type of ankle surgery and pain. Conclusion: Patients with psychological distress and more severe preoperative pain were more at risk to develop acute pain and chronic pain after ankle surgery regardless of the surgery performed. Level of Evidence: Level II, prospective comparative study.
Validation of the Ankle Osteoarthritis Scale Instrument for Preoperative Evaluation of End-Stage Ankle Arthritis Patients Using Item Response Theory
Authors: Liu Guiping , Peterson Alexander C. , Wing Kevin , Crump Trafford , Younger Alastair , Penner Murray , Veljkovic Andrea , Foggin Hannah , Sutherland Jason M. 
Published: January 2019

Background: Significant ankle arthritis results in functional limitations and patient morbidity. There is a need to measure symptoms and the impact of interventions on patient’s quality of life using valid and reliable patient-reported measurement instruments. The objective of this research was to validate the Ankle Osteoarthritis Scale instrument in the preoperative setting using factor analysis, item response theory, and differential item function methods. Methods: This research is based on secondary analysis of patients scheduled for ankle arthrodesis or total ankle replacement in Vancouver, Canada. Participants completed the instrument between September 2014 and August 2017. Item response theory was used to estimate item difficulty and discrimination parameters, controlling for study participants’ underlying level of ankle function. Differential item function was examined for sex, age group, and surgery. There were 88 participants. Results: Modification indices suggested that item 10, “walking around the house,” would better fit the pain domain rather than the disability domain. Items in the pain domain displayed a range of discrimination and difficulty. Items in the disability domain exhibited a range of discrimination, though the disability domain had low difficulty. Differential item functioning for sex, age group, and ankle arthrodesis or total ankle replacement appeared to be ignorable. Conclusion: This evaluation of the Ankle Osteoarthritis Scale found the instrument to be a strong measure of the effect of pain and dysfunction among patients with end-stage ankle arthritis, even when removing items 7 and 8, supporting its prior use in numerous clinical studies. Level of Evidence: Level II, prospective comparative study.
Exploring and modelling team performances of the Kaggle European Soccer database
Authors: Carpita Maurizio , Ciavolino Enrico , Pasca Paola 
Published: January 2019

This study explores a big and open database of soccer leagues in 10 European countries. Data related to players, teams and matches covering seven seasons (from 2009/2010 to 2015/2016) were retrieved from Kaggle, an online platform in which big data are available for predictive modelling and analytics competition among data scientists. Based on both preliminary data analysis, experts’ evaluation and players’ position on the football pitch, role-based indicators of teams’ performance have been built and used to estimate the win probability of the home team with the binomial logistic regression (BLR) model that has been extended including the ELO rating predictor and two random effects due to the hierarchical structure of the dataset. The predictive power of the BLR model and its extensions has been compared with the one of other statistical modelling approaches (Random Forest, Neural Network, k-NN, Naïve Bayes). Results showed that role-based indicators substantially improved the performance of all the models used in both this work and in previous works available on Kaggle. The base BLR model increased prediction accuracy by 10 percentage points, and showed the importance of defence performances, especially in the last seasons. Inclusion of both ELO rating predictor and the random effects did not substantially improve prediction, as the simpler BLR model performed equally good. With respect to the other models, only Naïve Bayes showed more balanced results in predicting both win and no-win of the home team.
Conducting clinical trials—costs, impacts, and the value of clinical trials networks: A scoping review
Authors: Bentley Colene , Cressman Sonya , van der Hoek Kim , Arts Karen , Dancey Janet , Peacock Stuart 
Published: January 2019

Background A significant barrier to conducting clinical trials is their high cost, which is driven primarily by the time and resources required to activate trials and reach accrual targets. The high cost of running trials has a substantial impact on their long-term feasibility and the type of clinical research undertaken. Methods A scoping review of the empirical literature on the costs associated with conducting clinical trials was undertaken for the years 2001–2015. Five reference databases were consulted to elicit how trials costs are presented in the literature. A review instrument was developed to extract the content of in-scope papers. Findings were characterized by date and place of publication, clinical disease area, and network/cooperative group designation, when specified. Costs were captured and grouped by patient accrual and management, infrastructure, and the opportunity costs associated with industry funding for trials research. Cost impacts on translational research and health systems were also captured, as were recommendations to reduce trial expenditures. Since articles often cited multiple costs, multiple cost coding was used during data extraction to capture the range and frequency of costs. Results A total of 288 empirical articles were included. The distribution of reported costs was: patient management and accrual costs (132 articles), infrastructure costs (118 articles) and the opportunity costs of industry sponsorship (72 articles). 221 articles reported on the impact of undertaking costly trials on translational research and health systems; of these, the most frequently reported consequences were to research integrity (52% of articles), research capacity (36% of articles) and running low-value trials (34% of articles). 254 articles provided recommendations to reduce trial costs; of these, the most frequently reported recommendations related to improvements in: operational efficiencies (33% of articles); patient accrual (24% of articles); funding for trials and transparency in trials reporting (18% of articles, each). Conclusion Key findings from the review are: 1) delayed trial activation has costs to budgets and research; 2) poor accrual leads to low-value trials and wasted resources; 3) the pharmaceutical industry can be a pragmatic, if problematic, partner in clinical research; 4) organizational know-how and successful research collaboration are benefits of network/cooperative groups; and 5) there are spillover benefits of clinical trials to healthcare systems, including better health outcomes, enhanced research capacity, and drug cost avoidance. There is a need for more economic evaluations of the benefits of clinical research, such as health system use (or avoidance) and health outcomes in cities and health authorities with institutions that conduct clinical research, to demonstrate the affordability of clinical trials, despite their high cost.
Therapeutic challenges in the treatment of systemic inflammatory disease in pregnancy
Authors: Fredrickson Jared S , Kolfenbach Jason R , Holmes Jennifer L , Cathcart Jennifer N , Lynch Anne M , Palestine Alan G 
Published: January 2019

Background Granulomatosis with polyangiitis and Behçet’s disease can occur during pregnancy and may be treated by ophthalmologists, rheumatologists, and obstetricians. We hypothesized that specialty training would affect the way physicians selected therapy. Methods Using an online questionnaire, 209 uveitis specialists, 853 rheumatologists, and 2500 obstetricians were surveyed. Respondents were given clinical vignettes containing a female patient who was contemplating pregnancy or in the first trimester and was diagnosed with granulomatosis with polyangiitis or Behçet’s disease. Results In the patient with granulomatosis with polyangiitis, therapy choice between specialties for biologic versus non-biologic systemic immunosuppressive medications was significantly different for both the non-pregnant and pregnant patient (p < 0.00001, p < 0.00003). In the non-pregnant patient diagnosed with Behçet’s disease, the therapy choice between biologic versus non-biologic medications was also significantly different (p < 0.0003). Conclusions Specialty training affects how physicians manage granulomatosis with polyangiitis and Behçet’s disease. Development of inter-specialty guidelines and treatment plans may improve outcomes, communication, and patient care.
Survivin and insulin-like growth factor-I: potential role in the pathogenesis of acne and post-acne scar
Authors: El-Tahlawi Samar , Ezzat Mohammad Noha , Mohamed El-Amir Azza , Sayed Mohamed Heba 
Published: January 2019

Backgrounds/objectives: Acne is an inflammatory disease of the pilosebaceous unit (PSU). The over-expression of survivin and insulin-like growth factor (IGF)-I in some fibrotic disorders suggests a possible implication in the pathogenesis of acne and or post-acne scar. We aimed to evaluate their potential role in pathogenesis in acne and post-acne scar. Methods: Serum survivin and IGF-I levels were estimated in 30 patients with acne and post-acne scar compared to 30 controls. Results: There was a statistically significant difference in survivin and IGF-I levels between controls and patients ( P < 0.05). However, there was no linear correlation between survivin and IGF-I. Conclusions: Survivin and IGF-I could have a possible role in the pathogenesis of active acne and in post-inflammatory acne scar.