bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential retinal biomarkers for dementia: what is new?
Authors: Cheung Carol Y. , Chan Victor T.T. , Mok Vincent C. , Chen Christopher , Wong Tien Y. 
Published: December 2018

Purpose of reviewTo summarize the current findings on clinical retinal diseases and retinal imaging changes with dementia, focusing on Alzheimer's disease.Recent findingsStudies observed that clinical retinal diseases such as age-related macular degeneration, open-angle glaucoma and diabetic retinopathy are related to dementia, but the associations are not entirely consistent. In terms of the retinal neuronal structure, multiple retinal neuronal layers are significantly thinner in Alzheimer's disease dementia, such as the parapapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GC-IPL). Recent studies further demonstrated that macular GC-IPL and macular RNFL are also significantly thinner in the preclinical stage of Alzheimer's disease. A thinner RNFL is also associated with a significantly increased risk of developing both cognitive decline and Alzheimer's disease dementia. In addition, studies consistently showed that retinal vascular changes are associated with poorer cognitive performance, as well as prevalent and incident Alzheimer's disease dementia.SummaryThe current findings support the concept that changes in the retina, particular in retinal neuronal structure and vasculature, can reflect the status of cerebral neuronal structure and vasculature, highlighting the potential role of retinal changes as biomarkers of dementia.
Advances in the understanding of headache in idiopathic intracranial hypertension
Authors: Mollan Susan P. , Hoffmann Jan , Sinclair Alexandra J. 
Published: December 2018

Purpose of review
To review the most relevant developments in the understanding of headache in idiopathic intracranial hypertension (IIH).

Recent findings
The phenotype of the typical IIH headache is diverging from the historical thinking of a raised intracranial pressure headache, with the majority being classified as having migraine. A larger proportion of those with IIH have a past medical history of migraine, compared with the general population, highlighting the importance of re-examining those who have a change or escalation in their headache. The mechanisms underlying headache in IIH are not understood. Additionally, factors which confer a poor headache prognosis are not established. It is clear, however, that headache has a detrimental effect on all aspects of the patient's quality of life and is currently ranked highly as a research priority by IIH patients to better understand the pathophysiology of headache in IIH and identification of potential headache specific therapeutic agents.

Summary
Headache remains the predominate morbidity in the majority of those with IIH. Headache management is an unmet need in IIH and future studies are required to investigate the probable complex mechanisms, as well as effective management.
Prediction of a plant intracellular metabolite content class using image-based deep learning
Authors: Krishnan Neeraja M , Panda Binay 
Published: December 2018

AbstractPlant-derived secondary metabolites play a vital role in the food, pharmaceutical, agrochemical and cosmetic industry. Metabolite concentrations are measured after extraction, biochemistry and analyses, requiring time, access to expensive equipment, reagents and specialized skills. Additionally, metabolite concentration often varies widely among plants, even within a small area. A quick method to estimate the metabolite concentration class (high or low) will significantly help in selecting trees yielding high metabolites for the metabolite production process. Here, we demonstrate a deep learning approach to estimate the concentration class of an intracellular metabolite, azadirachtin, using models built with images of leaves and fruits collected from randomly selected Azadirachta indica (neem) trees in an area spanning >500,000 sqkms and their corresponding biochemically measured metabolite concentrations. We divided the input data randomly into training- and test-sets ten times to avoid sampling bias and to optimize the model parameters during cross-validation. The training-set contained >83,000 fruit and >86,000 leaf images. The best models yielded prediction errors of 19.13% and 15.11% (for fruit), and 8% and 26.67% (for leaf), each, for low and high metabolite classes, respectively. We further validated the fruit model using independently collected fruit images from different locations spanning nearly 130,000 sqkms, with 70% accuracy. We developed a desktop application to scan offline image(s) and a mobile application for real-time utility to predict the metabolite content class. Our work demonstrates the use of a deep learning method to estimate the concentration class of an intracellular metabolite using images, and has broad applications and utility.
Muscle-secreted G-CSF as a metabolic niche factor ameliorates loss of muscle stem cell in aged mice
Authors: Li Hu , Chen Qian , Li Changyin , Zhong Ran , Zhao Yixia , Zhang Qianying , Tong Weimin , Zhu Dahai , Zhang Yong 
Published: December 2018

SummaryFunction and number of muscle stem cells (satellite cells, SCs) declines with muscle aging. Although SCs are heterogeneous and different subpopulations have been identified, it remains unknown if a specific subpopulation of muscle SCs selectively decreases during aging. Here, we find Pax7Hi cells are dramatically reduced in aged mice and this aged-dependent loss of Pax7Hi cells is metabolically mediated by myofiber-secreted granulocyte-colony stimulating factor G-CSF as the Pax7Hi SCs are replenished by exercise-induced G-CSF in aged mice. Mechanistically, we show that transcription of G-CSF (Csf3) gene in myofibers is regulated by MyoD in a metabolism-dependent manner and the myofibers-secreted G-CSF acts as a metabolic niche factor required for establishing and maintaining the Pax7Hi SC subpopulation in adult and physiological aged mice by promoting the asymmetric division of Pax7Hi and Pax7Mi SCs. Together, our findings uncover a metabolic niche role of muscle metabolism in regulating Pax7 SC heterogeneity in mice.HighlightsSingle cell RNA-seq unveils Pax7Hi and Pax7Lo cells are two distinct subpopulations.Pax7Hi SCs are enriched in glycolytic fibers and reduced in aging muscle.Metabolic niche factor G-CSF is required for regulating dynamic change of Pax7 SCs.G-CSF replenishes Pax7Hi cells by stimulating asymmetric division of Pax7Mi cells.
The corrosion behavior of X65 steel in CO2/oil/water environment of gathering pipeline
Authors: Cheng Yuanpeng , Bai Yu , Li Zili , Liu JianGuo 
Published: December 2018

Purpose
The purpose of this paper was to investigate the corrosion behavior of X65 steel in the CO2/oil/water environment using mass loss method, potentiodynamic polarization technique and characterization of the corroded surface techniques.

Design/methodology/approach
The weight loss analysis, electrochemical study and surface investigation were carried out on X65 steel that had been immersed in the CO2/oil/water corrosive medium to understand the corrosion behavior of gathering pipeline steel. The weight loss tests were carried out in a 3L autoclave, and effects of flow velocity, CO2 partial pressure and water cut on the CO2 corrosion rate of X65 steel were studied. Electrochemical studies were carried out in a three-electrode electrochemical cell with the test temperature of 60°C and CO2 partial pressure of 1 atm by recording open circuit potential/time and potentiodynamic polarization characteristics. The surface and cross-sectional morphologies of corrosion product scales were characterized using scanning electron microscopy. The phases of corrosion product scales were investigated using X-ray diffraction.

Findings
The results showed that corrosion rates of X65 steel both increased at first and then decreased with the increase of flow velocity and CO2 partial pressure, and there were critical velocity and critical pressure in the simulated corrosive environment, below the critical value, the corrosion products formed on the steel surface were loose, porous and unstable, higher than the critical value, the corrosion product ?lms were dense, strong adhesion, and had a certain protective effect. Meanwhile, when the flow velocity exceeded the critical value, oil film could be adsorbed on the steel surface more evenly, corrosion reaction active points were reduced and the steel matrix was protected from being corroded and crude oil played a role of inhibitor, thus it influenced the corrosion rate. Above the critical CO2 partial pressure, the solubility of CO2 in crude oil increased, the viscosity of crude oil decreased and its fluidity became better, so that the probability of oil film adsorption increased, these factors led to the corrosion inhibition of X65 steel reinforced. The corrosion characteristics of gathering pipeline steel in the corrosive environment containing CO2 would change due to the presence of crude oil.

Originality/value
The results can be helpful in selecting the suitable corrosion inhibitors and targeted anti-corrosion measures for CO2/oil/water corrosive environment.
Food-system actors’ perspectives on trust: an international comparison
Authors: Tonkin Emma , Wilson Annabelle M. , Coveney John , Henderson Julie , Meyer Samantha B. , McCarthy Mary Brigid , O’Reilly Seamus , Calnan Michael , McGloin Aileen , Kelly Edel , Ward Paul 
Published: December 2018

PurposeThe purpose of this paper is to compare the perspectives of actors who contribute to trust in the food system in four high income countries which have diverse food incident histories: Australia, New Zealand (NZ), the United Kingdom (UK) and the Island of Ireland (IOI), focussing on their communication with the public, and their approach to food system interrelationships.Design/methodology/approachData were collected in two separate studies: the first in Australia, NZ and the UK (Study 1); and the second on the IOI (Study 2). In-depth interviews were conducted with media, food industry and food regulatory actors across the four regions (n=105, Study 1;n=50, Study 2). Analysis focussed on identifying similarities and differences in the perspectives of actors from the four regions regarding the key themes of communication with the public, and relationships between media, industry and regulators.FindingsWhile there were many similarities in the way food system actors from the four regions discussed (re)building trust in the context of a food incident, their perceptions differed in a number of critical ways regarding food system actor use of social media, and the attitudes and approaches towards relationships between food system actors.Originality/valueThis paper outlines opportunities for the regions studied to learn from each other when looking for practical strategies to maximise consumer trust in the food system, particularly relating to the use of social media and attitudes towards role definition in industry–regulator relationships.
Evaluation of provincial integration degree of “internet + industry” based on matrix grey relational analysis
Authors: Yang Lu , Xie Naiming 
Published: December 2018

Purpose
The purpose of this paper is to establish a new evaluation system to assess the degree of integration between industry and the internet. And use the gray correlation matrix method to evaluate the “internet + industry” integration degree of China’s provinces.

Design/methodology/approach
This paper establishes a new evaluation system to assess the degree of integration between industry and the internet using the matrix gray relational analysis method.

Findings
The main indexes and its rankings of the provinces’ integration degree and the rankings of the provinces’ integration degree are obtained.

Practical implications
The ranking of the degree of integration of various provinces in the country has certain guiding significance in promoting the development of “internet +” and “industry 4.0.”

Originality/value
Establishing a new model for the quantitative assessment of the degree of fusion, this method has a positive impact on the quantitative assessment of “internet + industrial” integration.
Effects of dissolved solute on unsteady double-diffusive mixed convective flow of a Buongiorno’s two-component nonhomogeneous nanofluid
Authors: Aliakbarzadeh Kashani Davood , Dinarvand Saeed , Pop Ioan , Hayat Tasawar 
Published: December 2018

PurposeThe purpose of this paper is to numerically study the unsteady double-diffusive mixed convective stagnation-point flow of a water-based nanofluid accompanied with one salt past a vertical flat plate. The effects of Brownian motion and thermophoresis parameters are also introduced through Buongiorno’s two-component nonhomogeneous equilibrium model in the governing equations.Design/methodology/approachIn the present explanation of double-diffusive mixed convective model, there are four boundary layers entitled: velocity, thermal, solutal concentration and nanoparticle concentration. The resulting basic equations are solved numerically via an efficient Runge–Kutta fourth-order method with shooting technique after the governing nonlinear partial differential equations are converted into a system of nonlinear ordinary differential equations by the use of similarity transformations.FindingsTo avail the physical insight of problem, the effects of the mixed convection parameter, unsteadiness parameter and salt/nanoparticle parameters on the boundary layers behavior are investigated. Moreover, four possible types of diffusion problems entitled: double-diffusive nanofluid (DDNF), double-diffusive regular fluid (DDRF), mono-diffusive nanofluid (MDNF) and mono-diffusive regular fluid (MDRF) are considered to analyze and compare them in concepts of heat and mass transfer.Originality/valueThe results demonstrate that, for a regular fluid, without nanoparticle and salt (MDRF), the dimensionless heat transfer rate is smaller than other diffusion cases. As we include nanoparticle and salt (DDNF), the rate of heat transfer increases due to an increase in thermal conductivity and rate of diffusion of salt. Moreover, it is observed that the highest heat transfer rate is obtained for the situation that the thermophoretic effect of nanoparticles is negligible. Besides, the heat transfer rate enhances with the increase in the regular double-diffusive buoyancy parameter of salt.
Financial inclusion and land ownership status of women
Authors: Balasubramanian Senthil Arasu , Kuppusamy Thenmozhi , Natarajan Thamaraiselvan 
Published: December 2018

PurposeThe purpose of this paper is to empirically examine the influence of women’s land ownership status on their inclusion in developing economies.Design/methodology/approachThe study adopted a cross-sectional analysis. Data were taken from Global Findex data of World Bank and Indices of social development. Data were analysed using limited information maximum likelihood to establish the relationship between usage of basic financial services and women’s land ownership status variables. The study considers different demographic, social and economic factors as control variables. Socio-economic gender equality index and land ownership status of men are considered as instrumental variables in the estimations for controlling endogeneity problem.FindingsThe study proves that there is a significant influence of women’s land ownership status on their demand and usage of basic financial services. The results show that women who own land alone have a significant relationship for formal account ownership and formal savings but are deprived of formal and informal credit. The results find that women are more likely to avail of formal credit when they are backed by someone else in the family especially men. Irrespective of the wealth quintile to which women belong, they are deprived of credit if they do not own any land. The findings also show that women in higher wealth quintiles are more active in availing credit.Research limitations/implicationsThe study is limited to the extent of influence of women’s land ownership status on their demand for basic financial services.Practical implicationsThe study recommends appropriate economic and financial policies to encourage women to own, possess and use their land for personal as well as entrepreneurial activities. The study also suggests for policies to encourage women for joint ownership of land for better credit availability.Social implicationsFormal institutions must be more favourable for women in providing credit facilities because women play an essential role in economic development in developing economies.Originality/valueThis study is the first of its type in providing empirical evidence that women’s land ownership status influences their demand for basic financial services in developing countries.
Resource-based theory of college football team competitiveness
Authors: Omondi-Ochieng Peter 
Published: December 2018

PurposeThis paper aims to predict a college football team’s competitiveness using physical resources, human resources and organizational resources.Design/methodology/approachGuided by the resource-based theory, the study used archival data of 101 college football teams. The dependent variable was competitiveness (indicated by win-loss records), the independent variables were physical resources (operationalized as home attendance and total revenues), human resources (measured as coaches’ salary and coaches’ experience) and organizational resources (specified as conference rankings and the number of sports). Kendall Tau correlation and binary logistic regression were used to examine the associative and predictive competitive advantages.FindingsThe binary logistic regression model showed an overall percentage predictive correctness of 71.3%, with a NegelkerkeR2of 41.1% of the variance of all predictors – with coaches’ experience, total revenues and home attendance being the best predictors of generating competitive advantages that produced superior win-loss records.Research limitations/implicationsThe research focused exclusively on physical, organizational and human resources as sources of competitive advantage and not physiological and/or psychological variables.Practical implicationsCollege football teams aspiring to be competitive may benefit from this study by applying a three-fold strategy of hiring well-paid high performing and experienced coaches who can increase attendance and revenues.Originality/valueThe study was unique in two ways – one, it made clear the positive significance of coaches’ experience as a source of competitive advantage, and second, it highlighted the catalytic effects of revenues and attendance in fueling competitiveness.
The “next day, free delivery” myth unravelled
Authors: Buldeo Rai Heleen , Verlinde Sara , Macharis Cathy 
Published: December 2018

PurposeCurrently, it is unclear how omnichannel retailers can create a last mile offer that is both attractive and sustainable from an economic and environmental point of view. The purpose of this paper is to explore to which extent consumers are willing to adopt last mile options that are more sustainable and how these options should be composed to remain attractive.Design/methodology/approachTo this end, the authors surveyed a representative sample of Belgian consumers, using choice-based conjoint experiments, and analysed their preferences structures.FindingsConsumers’ preference goes out to free, next day delivery to an address of choice, on regular office hours during the week. However, when free delivery and return are offered, consumers are willing to collect their orders themselves or wait longer for their orders to arrive.Practical implicationsThe research findings are important for retailers that (plan to) operate an omnichannel model. For omnichannel retailers with a dense store network, the results indicate that consumers accept their store network as pick-up and return locations, allowing retailers to create a more efficient and sustainable supply chain in which their online and offline activities can be combined.Originality/valueThe research findings contribute to current literature and practice by combining “planet” and “profit” components of sustainability in last mile transport and applying it in the novel omnichannel environment.
A tale of complexity
Authors: Carvalho Hamilton Coimbra , Mazzon José Afonso , Santos Joaquim Rocha 
Published: December 2018

Purpose
The purpose of this paper is the development of a framework to address complex social problems. The paper proposes an integrative framework inspired in complexity sciences, using it to explain the demise of cigarettes in recent decades.

Design/methodology/approach
The paper uses the method of system dynamics to represent the complexity inherent in most social ecosystems where social marketers operate.

Findings
The framework identifies the major determinants of complex problems in social ecosystems, giving emphasis to the role performed by endogenous social structures. The paper presents the results of a simulation replicating the evolution of perceived attractiveness of cigarettes in recent decades, highlighting the role of the Surgeon General’s 1964 report in the USA as a catalyst force that accelerated the process of change.

Research limitations/implications
The limitations derive from the use of the system dynamics method, in particular the high level of aggregation of variables. Implications include the potential for increased cross-fertilization between social marketing and other disciplines concerned with social change.

Practical implications
The eight elements that compose the proposed framework can be identified or applied to any social ecosystem, helping in the identification of points with high leverage for social change.

Social implications
Proper understanding of how complex social problems arise is vital to increase the odds of success of social marketing interventions. The paper also highlights common threads in the development of problems in different social ecosystems.

Originality/value
The paper presents a novel framework for addressing the complexity inherent to the social ecosystems where social marketers operate.