bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Neuromodulatory Effects of ω-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms
Authors: Abdolahi Mina , Jafarieh Arash , Sarraf Payam , Sedighiyan Mohsen , Yousefi Abolghasem , Tafakhori Abbas , Abdollahi Hamed , Salehinia Farahnaz , Djalali Mahmoud 
Published: February 2019

Background:
Migraine is a common neuroinflammatory disorder characterized by recurrent
attacks of pain. Human and experimental models of migraine studies have demonstrated the role
played by COX-2/ iNOS in migraine’s neuroinflammatory pathogenesis. COX-2 and iNOS are closely
linked and both contribute to inflammation and neurogenic pain in the central nervous system. Omega-
3 fatty acids and curcumin, an active polyphenol of turmeric, have anti-inflammatory and neuroprotective
effects through several mechanisms, including the suppression of COX-2 and iNOS gene expression,
as well as their serum levels. The aim of the present study is to evaluate the nutrigenomic effects
of ω-3 fatty acids, nano-curcumin, and a combination of the two, on neuroinflammation and clinical
symptoms in migraine patients.

Methods:
This study reports the results of a clinical trial over a 2-month period, involving 74 episodic
migraine patients who received ω-3 fatty acids, nano-curcumin, a combination of them, or a placebo.
At the start and end of the study, the expression of COX-2/iNOS (in peripheral mononuclear blood
cells isolated from patients) and COX-2/iNOS serum levels were measured, using real-time PCR and
ELISA respectively. The frequency, severity and duration of pain attacks were also recorded.

Results:
The results of the present trial showed that ω-3 fatty acids and nano-curcumin can reinforce
each other’s effects in the downregulation of COX-2/iNOS mRNA, as well as reduce their serum levels.
In addition, the combination of ω-3 and nano-curcumin significantly reduced the frequency, severity
and duration of headaches (P<0.05).

Conclusion:
These findings indicate that combination therapy of ω-3 fatty acids and nano-curcumin
can be considered as a promising new approach in migraine prevention.
Iniciativa de Cidadania Europeia: Mais e Melhor Democracia na UE?
Authors: Carvalhais Isabel Estrada 
Published: February 2019

Este texto centra a sua análise sobre um dos novos instrumentos de participação democrática que o tratado de Lisboa consagra no âmbito do exercício da Cidadania Europeia: a iniciativa de Cidadania. Tomando como pano de fundo a discussão pública lançada em 2009 e recentemente concluída em Janeiro de 2010, o texto relembra algumas questões a que urge responder de modo a que se possa avançar rapidamente para uma implementação acessível e simples, ou seja, democrática e eficaz, deste instrumento, num contexto transeuropeu que necessariamente apresenta desafios acrescidos. O texto não esquece ainda a necessidade de retomar algumas questões a que chama de carácter fundador e que se prendem com a própria pertinência política da aplicação de um tal instrumento no contexto da cidadania europeia e no contexto da qualidade democrática da própria institucionalidade europeia.
Away Inside: Emigrants and Transnationalism Through the Eyes of Political Parties
Authors: Abrantes Manuel , Azevedo Joana , Belchior Ana Maria , Lisi Marco 
Published: February 2019

This article examines how political parties in Portugal organize concerning emigrants and the subject of migration outflow, uncovering the issues and strategies that they favour. The 2009 Portuguese legislative elections offer a privileged site for empirical inquiry. Not only are emigrants able to elect members of the national parliament through particular voting districts, but also a complete period of electoral campaigning under standard institutional conditions (rather than early elections) could thus be followed in real-time by the research team. Analysis draws chiefly on electoral manifestos, campaign activities, and first-hand interviews with members of the parliament and public officials. A close tie between the capacity of parties to organize abroad and the salience of issues related to the emigrant population in party programs is exposed. It is argued that the ambigous position of external voting between the strengthening of national(istic) bonds and transnational citizenship is disputed within the party system, since attitudes towards each of these perspectives vary across parties. Parties must therefore be understood as key players in the ongoing redefinition of the political agency of migrants, bearing a significant impact on their participation and representation. Last, implications for future research are addressed.
A Companhia de Jesus e as Culturas não Ocidentais: O Caso do Padre António Vieira
Authors: Beites Manso Maria de Deus 
Published: February 2019

Pretendemos sumariar alguns aspectos da actividade missionária, particularmente, da de António Vieira que contribuíram para a criação de um novo modelo missionário, tendo não só influenciado a história da Expansão e da Colonização Portuguesa como conduziram a um questionar constante sobre alguns valores morais e éticos, orientadores da sociedade do Antigo Regime e que estarão na base da aplicação prática dos grandes preceitos do Direito Natural moderno. Palavras-Chave: Companhia de Jesus, missão, colonização e Igreja.
Cultura, Europa e Mundialização: Dez Anos depois de O Esplendor do Caos de Eduardo Lourenço
Authors: Pedroso de Lima João Tiago 
Published: February 2019

1. Um caso singular numa obra consagrada.2. Como apresentar O Esplendor do Caos? Que esplendor? Uma hipótese de leitura: O mundo como catarata de imagens.3. Dez anos depois. Palavras-Chave: Eduardo Lourenço, Caos, Europa, América, História, Luz e Imagens.
The Impact of GAP-SOP on The Production and Technical Efficiency of Garlic in Temanggung Regency
Authors: Wardani Aristiyana Nur Tri , Darwanto Dwidjono Hadi 
Published: February 2019

Temanggung regency is the largest garlic producer region in Central Java Province. However, its productivity is still low compared to the other regencies since garlic farmers have not achieved technical efficiency and limitary garlic farming technology. Hence, it is necessary to investigate whether the input application in the process of garlic production has been at technically efficient level or not. This research aims to determine factors affecting garlic production, the level of technical efficiency and technical inefficiency of garlic farming in Temanggung Regency. The location of the research was determined by using purposive sampling. The sample selection used simple random sampling method with 60 garlic farmers as the respondent. The result shows that production factors such as land area, garlic seed, ZK fertilizer, pesticide and the level of application of garlic GAP-SOP have significant effect on garlic production. The average value of farmer’s technical efficiency is 0,811. It means that respondents in this study have been technically efficient. The socio-economic factors affecting technical inefficiency are the age, the number of worker in a family, the level of education and participation rate within farmer group. The improvement effort of technical efficiency of garlic farming can be done by optimizing the contribution of farmer group as a facility to access information. Therefore, it is able to improve the skills and knowledge of farmers to farm garlic.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI TINGKAT KEMISKINAN DI INDONESIA
Authors: Tisniwati Baiq 
Published: February 2019

Effort to reduce poverty zoom at Indonesian need real been known associate whatever factors or regarding low high it increase beggary at Indonesia, From analisis what does utilize secondary data with Regressions Model approaching Barganda was gotten to usufruct that there is one factor dominant the most regards tall its low foot up beggary at Indonesia, a spark of life number that figures is still was reached its health care application generalization that prop resident productivity in utilised economic activity prop more life reasonable. With equation estimation result that results that each a spark of life number decrease as big as 1 percent potentially raise poverty zoom (indigent population)as big as 6,9 percents or as big as 2.245. 010 soul, so is expected to the fore it can be formulated one effective public policy especially step-up accesses to basic the need as education and health (KB, mother welfare, base infrastructure, food and nutrient), so can reduce poverty zoom at this state and not only just as number decrease just but also ala kualitatif.
PENETAPAN KAWASAN ANDALAN SEBAGAI PUSAT PERTUMBUHAN PADA TINGKAT KABUPATEN/KOTA DI KALIMANTAN TIMUR
Authors: Wahyuningtiyas Dwi Dhasta 
Published: February 2019

The objective of this study was to identify how the patterns of economic growth was, to know what sector which was able to develop in an effort to determine development priorities, and analyze where the leading region as a center of economic growth on Regency/ city level in in East Kalimantan. While the supreme sector at regency/ city in East Kalimantan, based on the calculation of Location quotient (LQ) are supreme agricultural sector in the regency of Malinau, superior mining & quarrying sector in East Kutai regency, superior processing industry sector in Bontang City, the superior electricity sector, gas & water supply in the city of Tarakan, superior construction sector in the city of Balikpapan, trade, hotels & restaurants sector in the City of Tarakan, supreme transport & communications sector in Samarinda, the supreme financial, rental & services company sector in Samarinda City, and superior services sector in Samarinda. The leading areas as growth center on regency/ city level in East Kalimantan were Balikpapan and Tarakan City.
ANALISIS HARGA SAHAM PADA PERUSAHAAN ASURANSI YANG GO PUBLIK DI BURSA EFEK INDONESIA PERIODE 2005 – 2009
Authors: Amarullah Sri Marniyati , Hadi Syamsul 
Published: February 2019

The purpose of this study was to measure the influence of Price Earning Ratio (PER), Leverage Ratio (LR), Return On Equity (ROE), Price to Book Value (PBV) on Stock price in the insurance company. The analysis used the quantitative analysis of multiple linear regression model using ordinary least squares (OLS). From the results, it could be explain that the variables price earning ratio, leverage ratio, return on equity and price to book value has a significant influence on Stock price together was amounted to F calculated 3,896 > F table 2,61. From the t test, each variables that significantly influence the Stock price were PER (2,108 t calculate > t-table 2,021), ROE (2,654 t calculated > t-table 2,021. On the contrary, the variables that were not impact significantly were LR (1,318 t calculated < t-table 2,021) and PBV (-3,141 t calculated > t-table -2,021). Based on these results, obtained empirical evidence that could be considerated towards a more in-depth study on Stock price. It would be interesting if further study pay attention to the technical factors as well as policies set by the government.
O tombamento da Gruta de Angico: disputas da memória do cangaço no sertão nordestino
Authors: Ramos Filho Vagner Silva 
Published: February 2019

Este trabalho discute a cultura da memória contemporânea do cangaço, fenômeno de banditismo do nordeste brasileiro, atentando-se principalmente às rememorações e comemorações do cangaceiro Lampião, mais conhecido como o “Rei do Cangaço”. Busca-se entender, em particular, a historicidade das ações e representações relacionadas à “Gruta de Angico”, local onde os principais cangaceiros morreram e que depois transformou-se em local de culto ao cangaço. Para tanto, analisamos os acordos e conflitos em torno do processo de tombamento da Gruta ao longo da década de 1980, observando as variações do lugar da memória do cangaço na temporalidade nordestina, a fim de problematizar ditas identidades regionais.
Potential Nervous System Sensitization in Patients With Persistent Lower Extremity Tendinopathies: 3 Case Reports
Authors: Jayaseelan Dhinu J. , Weber Matthew J. , Jonely Holly 
Published: February 2019

Background Tendinopathy is a condition often associated with pain and functional and sport performance limitations. While targeted exercise prescriptions are often effective, many patients with tendinopathy develop persistent symptoms. Emerging evidence suggests a possible link between nervous system sensitization and tendinopathy. If so, identifying and treating specific pain mechanisms may improve outcomes. Case Description Three patients were seen in physical therapy for complaints of ongoing chronic tendon pain and self-reported disability, despite being treated previously and receiving evidence-informed care. Upon examination, each patient demonstrated signs consistent with possible dysfunction of central pain mechanisms. Joint mobilization, pain neuroscience education, and aerobic exercise were primary interventions in each case to decrease pain and improve function. Outcomes The 3 patients were treated for 5 sessions over the course of 8 weeks. Clinically significant improvement was noted in measures of pain, self-reported function, and pressure pain thresholds. At discharge, all patients were able to run without symptoms, and improvement was maintained at 1-year follow-up. Discussion Tendinopathy, while often described as local pain and dysfunction, may be associated with dysfunction of the nervous system. Identifying and treating pain mechanisms in addition to relevant impairments may be an appropriate intervention approach for individuals with tendinopathy. Level of Evidence Therapy, level 4. J Orthop Sports Phys Ther 2019;49(4):272–279. Epub 13 Feb 2019. doi:10.2519/jospt.2019.8600
Patient and Parent Perceptions of Rehabilitation Factors That Influence Outcomes After Anterior Cruciate Ligament Reconstruction and Clearance to Return to Sport in Adolescents and Young Adults
Authors: Paterno Mark V. , Schmitt Laura C. , Thomas Staci , Duke Nicholas , Russo Rebecca , Quatman-Yates Catherine C. 
Published: February 2019

Background Wide variation in outcomes after anterior cruciate ligament reconstruction (ACLR) exists among adolescents and young adults. However, little evidence is available regarding key rehabilitation factors that may be driving these differences. Objective To explore patient and parent perceptions of key rehabilitation drivers related to outcomes after ACLR. Methods In this qualitative study, which used an interpretive phenomenological methodology, semi-structured interviews were conducted with patients who had returned to sport after ACLR and with their parents. The interviews asked about respondents' experience with physical therapy and how it related to their outcomes after ACLR. The interviews were recorded, transcribed, and coded. Themes were then identified using open and axial coding processes. Results There were 3 primary themes that patients and parents perceived as key factors influencing their rehabilitation outcomes after ACLR: (1) patient attributes (ie, motivation, confidence, accountability, access to resources, and social support), (2) physical therapist-patient relationship qualities (physical therapist as guide, motivator, booster of confidence, fosterer of perseverance, and coordinator of care), and (3) elements of the system (ie, availability and utilization of therapy visits, clinic environment, and coordination among care providers). Conclusion Patient and parent perspectives of key drivers that influence ACLR rehabilitation outcomes include patient, therapist, and system factors. Developing specific strategies to target these factors may enhance patient and parent perceptions of the experience. The awareness gained from these results provides a foundation for future studies examining how these factors affect outcomes and how to improve rehabilitation after ACLR. Level of Evidence Therapy, level 3. J Orthop Sports Phys Ther 2019;49(8):576–583. Epub 13 Feb 2019. doi:10.2519/jospt.2019.8608
Treatment Effect Sizes of Mechanical Diagnosis and Therapy for Pain and Disability in Patients With Low Back Pain: A Systematic Review
Authors: Halliday Mark H. , Garcia Alessandra N. , Amorim Anita B. , Machado Gustavo C. , Hayden Jill A. , Pappas Evangelos , Ferreira Paulo H. , Hancock Mark J. 
Published: February 2019

Background Mechanical Diagnosis and Therapy (MDT) is a treatment-based classification system founded on 3 core principles: classification into diagnostic syndromes, classification-based intervention, and appropriate application of force. Many randomized controlled trials have investigated the efficacy of MDT for low back pain; however, results have varied. The inconsistent delivery of MDT across trials may explain the different findings. Objectives To compare treatment effect sizes for pain or disability between trials that delivered MDT consistent with the core principles of the approach and trials that met some or none of these principles. Methods In this systematic review, databases were searched from inception to June 2018 for studies that delivered MDT compared to nonpharmacological, conservative control interventions in patients with low back pain and reported outcomes of pain or disability. Studies were classified as “adherent” (meeting the core principles of MDT) or “nonadherent” (using some or none of the principles of MDT). Data were extracted by 2 independent reviewers. Meta-regression procedures were used to analyze the effect of delivery mode on clinical outcomes, adjusting for covariates of symptom duration (less than or greater than 3 months) and control intervention (minimal or active). Results Studies classified as adherent to the MDT approach showed greater reductions in pain and disability of 15.0 (95% confidence interval: 7.3, 22.7) and 11.7 (95% confidence interval: 5.4, 18.0) points, respectively, on a 100-point scale compared to nonadherent trials. Conclusion This review provides preliminary evidence that treatment effects of MDT are greater when the core principles are followed. Level of Evidence Therapy, level 1a. J Orthop Sports Phys Ther 2019;49(4):219–229. Epub 13 Feb 2019. doi:10.2519/jospt.2019.8734
Pengaruh Berbagai Suhu Pirolisis Asap Cair dari Cangkang Sawit sebagai Bahan Pengumpal Lateks
Authors: Fauziati Fauziati , Priatni Ageng , Adiningsih Yuni 
Published: February 2019

Asap cair hasil pembakaran cangkang sawit pada proses pirolisis yang diperoleh pada suhu 3000C- 4000C merupakan asap cair yang terbaik yang dapat digunakan sebagai bahan penggumpal lateks. Tujuan penelitian ini adalah untuk mengetahui pengaruh suhu pembakaran cangkang sawit yang optimal melalui proses pirolisis ,sehingga dihasilkan asap cair yang dapat digunakan sebagai penggumpal lateks. Asap cair hasil pembakaran secara pirolisis pada suhu 300-4000C menghasilkan senyawa aktif yang mempunyai peranan sebagai bahan penggumpal lateks yaitu senyawa asam asetat, senyawa phenol dan pH rendah sebagai bahan anti bakteri dan jamur pada lateks.Pada suhu tersebut dihasilkan anti bakteri / anti jamur yaitu E. Colli , Staphilococus aureus dan Salmonella dengan kategori kuat dan sangat kuat. Pada suhu 300-4000C pH yang dihasilkan sebesar 2,8 dan kadar asam asetat yang dihasilkan 50,54% dan phenol yang dihasilkan sebesar 32,59% dimana kedua senyawa kimia ini sangat berpengaruh terhadap penggumpal lateks ,juga berpengaruh terhadap pertumbuhan bakteri .Kelebihan asap cair dibandingakan dengan asam formiat yang biasa digunakan sebagai penggumpal lateks adalah disamping senyawa asam asetat juga mengandung senyawa phenol yang berpengaruh terhadap pH dan anti jamur / bakteri sedangkan asam formiat hanya memberikan pH rendah dan waktu penggumpalan lateks yang cepat .
Molecular epidemiology of an enterovirus A71 outbreak associated with severe neurological disease, Spain, 2016
Authors: González-Sanz Rubén , Casas-Alba Didac , Launes Cristian , Muñoz-Almagro Carmen , Ruiz-García María Montserrat , Alonso Mercedes , González-Abad María José , Megías Gregoria , Rabella Nuria , del Cuerpo Margarita , Gozalo-Margüello Mónica , González-Praetorius Alejandro , Martínez-Sapiña Ana , Goyanes-Galán María José , Romero María Pilar , Calvo Cristina , Antón Andrés , Imaz Manuel , Aranzamendi Maitane , Hernández-Rodríguez Águeda , Moreno-Docón Antonio , Rey-Cao Sonia , Navascués Ana , Otero Almudena , Cabrerizo María 
Published: February 2019

Introduction
Enterovirus A71 (EV-A71) is an emerging pathogen that causes a wide range of disorders including severe neurological manifestations. In the past 20 years, this virus has been associated with large outbreaks of hand, foot and mouth disease with neurological complications in the Asia-Pacific region, while in Europe mainly sporadic cases have been reported. In spring 2016, however, an EV-A71 outbreak associated with severe neurological cases was reported in Catalonia and spread further to other Spanish regions.

Aim
Our objective was to investigate the epidemiology and clinical characteristics of the outbreak.

Methods
We carried out a retrospective study which included 233 EV-A71-positive samples collected during 2016 from hospitalised patients. We analysed the clinical manifestations associated with EV-A71 infections and performed phylogenetic analyses of the 3’-VP1 and 3Dpol regions from all Spanish strains and a set of EV-A71 from other countries.

Results
Most EV-A71 infections were reported in children (mean age: 2.6 years) and the highest incidence was between May and July 2016 (83%). Most isolates (218/233) were classified as subgenogroup C1 and 217 of them were grouped in one cluster phylogenetically related to a new recombinant variant strain associated with severe neurological diseases in Germany and France in 2015 and 2016. Moreover, we found a clear association of EV-A71-C1 infection with severe neurological disorders, brainstem encephalitis being the most commonly reported.

Conclusion
An emerging recombinant variant of EV-A71-C1 was responsible for the large outbreak in 2016 in Spain that was associated with many severe neurological cases.
ATTITUDE TO PREVENTION OF HEART DISEASES AND STRESS IN THE FAMILY IN THE OPEN CITY POPULATION: PREVALENCE AND INTERRELATIONS
Authors: Akimov A. M. , Kayumova M. M. , Gafarov V. V. , Kuznetsov V. A. 
Published: February 2019

Objective: to determine the associations of attitudes towards their health and family stress in men and women of an open urban population.Material and Methods. To carry out a one-stage epidemiological study on an open urban population using the “random numbers” method, a representative sample of the population was drawn from the electoral lists of citizens of the Central Administrative District of Tyumen in the number of 2000 people, 250 people in each sex-age group (25–34, 35–44, 45–54, 55–64 years). The study was conducted with a response rate of 77.7% (85.0% among men and 70.3% among women) according to rigidly standardized epidemiological methods. As part of the cardiological screening for the WHO MONICAMOPSY program algorithms, a survey was conducted on the “Knowledge and Attitude to Your Health” questionnaire, and some parameters of the population’s attitude to their health and family stress were analyzed.Results.In general, in the Tyumen population, women demonstrated a more responsible attitude towards their health. In the presence of stress in the family, readiness for urgent measures in case of pain or discomfort in the heart area was ambiguous: higher among women in an emergency situation (with one or frequent conflicts in the family during the last 12 months, and also in the absence of conditions for home recreation ), and vice versa, in the situation of recurring conflicts (with several conflicts in the family during the last 12 months), the tendency to regular visits to the doctor under stress was observed among men.Conclusion. Analysis of the factors of chronic social stress in relation to the attitude towards the prevention of heart disease in the open population showed that the program of primary prevention of CVD, in addition to information technologies, should include correction of factors of chronic social stress, in particular, stress in the family among men and women of working age.