bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of endometrial echo pattern transformation after hCG trigger in predicting IVF pregnancy outcome: a prospective cohort study
Authors: Hou Zhaojuan , Zhang Qiong , Zhao Jing , Xu Aizhuang , He Aihua , Huang Xi , Xie Shi , Fu Jing , Xiao Lan , Li Yanping 
Published: September 2019

AbstractBackgroundThere is much value in identifying non-invasive ways of measuring endometrial receptivity, as it has the potential to improve outcomes following in vitro fertilization (IVF). It has been suggested that endometrial echogenicity on the day of hCG administration was a good marker of endometrial receptivity. In the daily practice, we notice that patients with non-homogeneous hyperechoic endometrium on the embryo transfer day usually have lower pregnancy rates. We therefore extended the research onward transformation of echo pattern after hCG trigger to analyze the relationship between endometrial echogenicity transformation and IVF outcomes.MethodsA total of 146 infertile women undergoing their first IVF cycle were recruited in the prospective cohort study from August 2017 through August 2018. A series of endometrial echo pattern monitoring was carried out in these patients after hCG trigger: hCG day, from 1 through 3 days after ovum pick-up (OPU + 1, OPU + 2, OPU + 3).ResultsThe endometrial echogenicity value was calculated as the ratio of the hyperechogenic endometrial area over the whole endometrial area. Clinical pregnancy rate and embryo implantation rate had positive relationship with echogenicity value. The ROC curve analysis of endometrial echogenicity showed the area under curve was greatest on the second day after oocyte retrieval (OPU + 1, 2, 3 were 0.738, 0.765, 0.714 respectively) versus pregnancy. Endometrial echogenicity value on OPU + 2 had a higher predictive efficiency, and the cutoff value was 76.5%. The sensitivity was 61.3% and specificity was 82.0%. When putting the cut-off at <60%, the sensitivity was 93.8% and the specificity was 23.1%.ConclusionsThe endometrial echogenicity value on OPU + 2 was recommended to evaluate endometrial receptivity. It seemed appropriate for clinicians to provide a ‘freeze all’ IVF cycle and transfer in a subsequent frozen-thawed embryos cycle when echogenicity value <60% on OPU + 2.Trial registrationThe registration number wasChiCTR-OOC-17012214and the registration date was August 1st, 2017.
Supplemental Intraoperative Oxygen Does Not Promote Acute Kidney Injury or Cardiovascular Complications After Noncardiac Surgery: Subanalysis of an Alternating Intervention Trial
Authors: Ruetzler Kurt , Cohen Barak , Leung Steve , Mascha Edward J. , Knotzer Johann , Kurz Andrea , Sessler Daniel I. , Turan Alparslan 
Published: September 2019

BACKGROUND:
Perioperative hyperoxia has been recommended by the World Health Organization and the Centers for Disease Control and Prevention for the prevention of surgical site infections. Based on animal studies and physiological concerns, the kidneys and heart may be at risk from hyperoxia. We therefore conducted 2 unplanned subanalyses of a previous alternating cohort trial in which patients having colorectal surgery were assigned to either 30% or 80% inspired intraoperative oxygen. Specifically, we tested 2 coprimary hypotheses: (1) hyperoxia increases the incidence of acute kidney injury (AKI) within 7 postoperative days (PODs); and (2) hyperoxia worsens a composite of myocardial injury, in-hospital cardiac arrest, and 30-day mortality.

METHODS:
The underlying controlled trial included 5749 colorectal surgeries in 4481 patients, with the exposure alternating between 30% and 80% fraction of inspired oxygen (Fio
2) during general anesthesia at 2-week intervals over a period of 39 months. AKI was defined as a 1.5-fold increase in creatinine from the preoperative level to the highest value measured during the initial 7 PODs. Myocardial injury was defined by fourth-generation troponin-T level >0.03 ng/mL. We assessed the effect of 80% vs 30% oxygen on the outcomes using generalized estimating equation (GEE) logistic models that adjusted for the possible within-patient correlation across multiple potential operations for a patient on different visits.

RESULTS:
For the AKI outcome, 2522 surgeries were allocated to 80% oxygen and 2552 to 30% oxygen. Hyperoxia had no effect on the primary outcome of postoperative AKI, with an incidence of 7.7% in the 80% oxygen group and 7.7% in the 30% oxygen group (relative risk = 0.99; 95% confidence interval [CI], 0.82–1.2; P = .95). One thousand six hundred forty-seven surgeries (all with scheduled troponin monitoring) were analyzed for the composite cardiovascular outcome. Hyperoxia had no effect on the collapsed composite of myocardial injury, cardiac arrest, and 30-day mortality, nor on any of its components (estimated relative risk = 0.71; 95% CI, 0.44–1.16; P = .17).

CONCLUSIONS:
We found no evidence that intraoperative hyperoxia causes AKI or cardiovascular complications in adults undergoing colorectal surgery. Consequently, we suggest that clinicians select intraoperative inspired oxygen fraction based on other considerations.
Intravenous Lidocaine for the Prevention of Postoperative Catheter-Related Bladder Discomfort in Male Patients Undergoing Transurethral Resection of Bladder Tumors: A Randomized, Double-Blind, Controlled Trial
Authors: Kim Doo-Hwan , Park Jun-Young , Yu Jihion , Lee Sang-A , Park Sooin , Hwang Jai-Hyun , Koh Gi-Ho , Kim Young-Kug 
Published: September 2019

BACKGROUND:
Male patients undergoing transurethral resection of bladder tumors (TURBT) are prone to suffer from catheter-related bladder discomfort (CRBD). Lidocaine administration has been widely performed to reduce postoperative pain. Here, the effect of intravenous lidocaine administration on moderate-to-severe CRBD was evaluated in male patients undergoing TURBT.

METHODS:
Patients were randomly allocated to receive intravenous lidocaine (1.5 mg/kg bolus dose followed by a 2 mg/kg/h continuous infusion during the intraoperative period, which was continued for 1 hour postsurgery; group L) or placebo (normal saline; group C). The primary outcome was moderate-to-severe CRBD at 0 hour postsurgery (on admission to the postanesthetic care unit), analyzed using the χ2 test. The secondary outcome was opioid requirement during the 24-hour postoperative period. None, mild, and moderate-to-severe CRBD at 1, 2, and 6 hours postsurgery, postoperative pain, patient satisfaction, side effects of lidocaine and rescue medications (tramadol and fentanyl), and surgical complications were also assessed.

RESULTS:
A total of 132 patients were included in the study (66 patients in each group). The incidence of moderate-to-severe CRBD at 0 hour postsurgery was significantly lower in group L than in group C (25.8% vs 66.7%, P < .001, relative risk: 0.386, 95% confidence interval: 0.248–0.602). Opioid requirements during the 24-hour postoperative period were significantly lower in group L than in group C (10.0 mg [interquartile range (IQR), 5.0–15.0 mg] vs 13.8 mg [IQR, 10.0–20.0 mg], P = .005). At 1 and 2 hours postsurgery (but not at 6 hours), the incidence of moderate-to-severe CRBD was significantly lower in group L than in group C (1 hour: 10.6% vs 27.3%, P = .026; 2 hours: 0.0% vs 15.2%, P = .003). Patient satisfaction was significantly greater in group L than in group C (5.0 [IQR, 4.8–6.0] vs 4.0 [IQR, 4.0–5.0], P < .001). No lidocaine-related side effects were reported. Rescue medication-related side effects and surgical complications did not differ significantly between the 2 groups.

CONCLUSIONS:
Intravenous lidocaine administration resulted in lower incidence of moderate-to-severe CRBD, lower opioid requirement, and higher patient satisfaction in male patients undergoing TURBT without evidence of significant side effects.
The Role for the Weak Interaction on the Stabilization of Copper-Containing Complex: DFT Investigation of Noncovalent Interactions in Ternary-Cu(II) (DA)(AA) Complexes (DA = Diamine and AA = Amino Acids) as a Model of Metalloprotein
Authors: Taborosi Attila , Yamaguchi Takahide , Odani Akira , Yamauchi Osamu , Kohzuma Takamitsu 
Published: September 2019

Abstract
In view of the key roles played by noncovalent or weak interactions in biological processes, it is important to understand them at the molecular level. Based on the results of the thermodynamic, spectroscopic and X-ray structural studies on ternary Cu(II) complexes, as platform molecules for ligand-ligand interactions, the presence of π-π interactions between aromatic rings (phenyl, phenol and indole) of amino acids and aromatic rings of imidazole, diamines have been shown. We carried out systematic theoretical studies using different DFT functionals (pure-GGA, meta-GGA, hybrid-GGA and meta-hybrid-GGA) with triple-ζ (def2TZVP) basis set for the experimentally determined structure of [Cu(hista)(Phe)]ClO4, to obtain the most suitable method. We gained reliable insight into the geometry, electronic structure and noncovalent interactions for different ternary complexes, [Cu(hista)(AA)]ClO4 (AA = Phe, Tyr, Trp, Leu, Ile, Ala, Met, Val) by applying the most accurate method (PW91/def2TZVP/CPCM). The calculated stability constants (logK) were in good agreement with the experimental results. We obtained knowledge of the differences in noncovalent interactions and excited states among the ternary Cu(II) complexes containing Phe, Tyr, and Trp by the Non-Covalent Interaction (NCI) and TDDFT methods.
Can thoracic nodes oligometastases be safely treated with image guided hypofractionated radiation therapy?
Authors: Franceschini Davide , Bianciardi Federico , Mazzola Rosario , De Rose Fiorenza , Gentile Piercarlo , Alongi Filippo , Scorsetti Marta 
Published: September 2019

Objective: To evaluate safety and efficacy of image guided-hypofractionated radiation therapy (IG-HRT) in patients with thoracic nodes oligometastases Methods: The present study is a multicenter analysis. Oligometastatic patients, affected by a maximum of five active lesions in three or less different organs, treated with IG-HRT to thoracic nodes metastases between 2012 and 2017 were included in the analysis. Primary end point was local control (LC), secondary end points were overall survival (OS), progression-free survival, acute and late toxicity. Univariate and multivariate analysis were performed to identify possible prognostic factors for the survival end points. Results: 76 patients were included in the analysis. Different RT dose and fractionation schedules were prescribed according to site, number, size of the lymph node(s) and to respect dose constraints for relevant organs at risk. Median biologically effective dose delivered was 75 Gy (interquartile range: 59–86 Gy). Treatment was optimal; one G1 acute toxicity and seven G1 late toxicities of any grade were recorded. Median follow-up time was 23.16 months. 16 patients (21.05%) had a local progression, while 52 patients progressed in distant sites (68.42 %). Median local relapse free survival was not reached, LC at 6, 12 and 24 months was 96.05% [confidence interval (CI) 88.26–98.71%], 86.68% (CI 75.86–92.87) and 68.21% (CI 51.89–80.00%), respectively. Median OS was 28.3 months (interquartile range 16.1–47.2). Median progression-freesurvival was 9.2 months (interquartile range 4.1–17.93). At multivariate analysis, RT dose, colorectal histology, systemic therapies were correlated with LC. Performance status and the presence of metastatic sites other than the thoracic nodes were correlated with OS. Local response was a predictor of OS. Conclusion: IG-HRT for thoracic nodes was safe and feasible. Higher RT doses were correlated to better LC and should be taken in consideration at least in patients with isolated nodal metastases and colorectal histology. Advances in knowledge: Radiotherapy is safe and effective treatment for thoracic nodes metastases, higher radiotherapy doses are correlated to better LC. Oligometastatic patients can receive IG-HRT also for thoracic nodes metastases.
Antiresorptive drug-related changes of the mandibular bone densitiy in medication-related osteonecrosis of the jaw patients
Authors: Heim Nils , Götz Werner , Kramer Franz-Josef , Faron Anton 
Published: September 2019

Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a well known side-effect of anti-resorptive drugs. Changes in bone density might potentially constitute the development of ONJ. This study aimed to investigate, to which degree bisphosphonates (bp) and denosumab (db) induce changes in bone density that can be determined from routine diagnostic CT. Methods: CT scans of 101 patients were investigated. MRONJ was present in 61 patients (n = 26: db-treated; n = 35 bp-treated). 40 patients were included as a reference group. Bone density was measured at two distinct locations in the mandible (M1: anterior of the mental foramen; M2: retromolar), each on the contralateral side to the necrosis. Results: The bone density values measured at both locations were found to be significantly higher in the bp-group compared to the db-group (p = 0.027) and to the reference-group (p = 0.016). Almost no difference (p = 0.84) in bone density value was found between the db- and reference-groups.Investigating the effect of duration of treatment, none of the measured values showed significant differences in both locations of db- and bp-group. Conclusion: The findings from this study suggest that that bisphosphonates change the microarchitecture of the alveolar bone by being embedded in the mandible, which may subsequently lead to a bp-specific corticalization, and a decrease in vascularization of the lower jaw. This process may be distinctive for bp-treatment and seems to induce the congestion of cancellous bone rather rapidly after the first administrations. This effect could not be determined in denosumab-treated patients.
The Value of Pop-Up Stores on Retailing Platforms: Evidence from a Field Experiment with Alibaba
Authors: Zhang Dennis J. , Dai Hengchen , Dong Lingxiu , Wu Qian , Guo Lifan , Liu Xiaofei 
Published: September 2019

We study the value of short-lived and experientially oriented pop-up stores, a popular type of omnichannel retail strategy, on both retailers that participate in pop-up store events and retailing platforms that host these retailers. We conduct a large-scale, randomized field experiment with Alibaba Group involving approximately 800,000 customers. We randomly assign customers to either receive a message about an upcoming weeklong pop-up store event organized by Alibaba’s business-to-consumer platform (Tmall.com) or not receive any message about the event. We find that our message increased foot traffic to the pop-up store and in turn boosted expenditure at participating retailers’ online stores at Tmall after the event ended. Furthermore, we use advanced Wi-Fi technology to track customers’ visits to the pop-up store—a missing component from past research that commonly relies on point-of-sale data. We find that pop-up store visits substantially increased customers’ subsequent expenditure at participating retailers’ Tmall stores. In addition, from a platform perspective we show that pop-up store visits increased customers’ purchases at retailers that sell related products on Tmall but did not participate in the pop-up store event. Additional analyses shed light on possible mechanisms underlying the cross-channel and spillover effects of pop-up stores and demonstrate that these effects were concentrated on prospective consumers. This paper was accepted by Vishal Gaur, operations management.
Amplicon Sequencing-Based Noninvasive Fetal Genotyping for RHD-Positive D Antigen-Negative Alleles
Authors: Takahashi Ken , Migita Ohsuke , Sasaki Aiko , Nasu Michiko , Kawashima Akihiro , Sekizawa Akihiko , Sato Taisuke , Ito Yuki , Sago Haruhiko , Okamoto Aikou , Nakabayashi Kazuhiko , Hata Kenichiro 
Published: September 2019

AbstractBACKGROUNDTo avoid hemolytic disease of the fetus and newborn resulting from maternal alloantibodies against fetal Rh antigens, anti-D immunoglobulin is routinely administered to RhD-negative pregnant women in Japan. Fetal RHD genotyping using cell-free DNA may prevent unnecessary antibody administration; however, current PCR-based methods, which detect RHD deletion, do not address the higher rates of RHD-positive D antigen-negative alleles in nonwhite populations without additional inspections.METHODSWe developed an amplicon-sequencing method that could estimate the type of paternally inherited fetal RHD allele from 4 major RHD alleles in the Japanese population: the D antigen-positive allele (RHD*01, 92.9%) and 3 D antigen-negative alleles (RHD*01N.01, 6.6%; RHD*01EL.01, 0.3%; RHD*01N.04, 0.1%) using cell-free DNA obtained from the blood plasma of pregnant women.RESULTSThe method correctly determined the fetal RhD type even when RhD-negative pregnant women possessed an RHD-positive D antigen-negative allele: RHD*01EL.01 or RHD*01N.04.CONCLUSIONSThis method is a reliable noninvasive fetal RHD genotyping method for Japanese and other East Asian populations. The genotyping principle of amplifying 2 different regions using the same primer pair and distinguishing them by their sequence difference during the subsequent mapping procedure is also theoretically applicable to RHD-positive D antigen-negative alleles prevalent in Africans. Therefore, this method offers an opportunity to consider targeted administration of anti-D immunoglobulin to RhD-negative pregnant women in East Asian and African countries and to increase the specificity of the fetal RHD genotyping implemented nationwide in several European countries.
Incremental Cost-Effectiveness of Aspiration Therapy vs Bariatric Surgery and No Treatment for Morbid Obesity
Authors: Mital Shweta , Nguyen Hai V. 
Published: September 2019

INTRODUCTION:
Despite its recent approval by the US Food and Drug Administration and Health Canada, aspiration therapy—one of the latest weight loss treatments—remains controversial. Critics have expressed concerns that the therapy could lead to bulimia and other binge eating disorders. Meanwhile, proponents argue that the therapy is less invasive, reversible, and cheaper than bariatric surgery. Cost-effectiveness of this therapy, however, is not yet established.

METHODS:
We developed a Markov model to estimate the incremental cost-effectiveness of aspiration therapy relative to 2 most common bariatric surgery procedures (gastric bypass and sleeve gastrectomy) and no treatment over a lifetime horizon. Costs were estimated from the health system's perspective using US data. Effectiveness was measured in terms of quality-adjusted life-years (QALYs).

RESULTS:
Despite being a cheaper procedure than bariatric surgery, aspiration therapy costs more than bariatric surgery in the long term because of its high maintenance costs (i.e., periodic replacement of device parts). It also yields lower QALYs than bariatric surgery because of its smaller weight loss effects. Thus, the therapy is dominated by bariatric surgery. In particular, compared with gastric bypass, it costs US$5,318 more and yields 1.31 fewer QALYs. However, aspiration therapy is cost-effective relative to no treatment with an incremental cost-effectiveness ratio of US$17,532 per QALY gained.

DISCUSSION:
Given its high lifetime costs and its modest weight loss effects, aspiration therapy is not cost-effective relative to bariatric surgery. However, it is a cost-effective treatment option for patients who lack access to bariatric surgery.
Hemostasis With Endoscopic Band Ligation for Rupture of Jejunal Varices
Authors: Shiratori Yasutoshi , Nakamura Kenji , Ikeya Takashi , Takagi Koichi , Fukuda Katsuyuki 
Published: September 2019

ABSTRACT
Compared with the variceal rupture in the esophagus or stomach, rupture of ectopic varices including those in the jejunum is rare, and a definitive hemostatic method is not established. We report our case and review the literature regarding the pathophysiology and hemostatic methods of ectopic varices. A patient presented with hematemesis and cardiopulmonary arrest following hemorrhagic shock. After resuscitation, we performed emergency endoscopy and diagnosed ruptured jejunal varices that were subsequently treated by endoscopic band ligation.
On commutator Krylov transitive and commutator weakly transitive Abelian p-groups
Authors: Chekhlov Andrey R. , Danchev Peter V. 
Published: September 2019

Abstract
We define the concepts of commutator (Krylov) transitive and strongly commutator (Krylov) transitive Abelian p-groups. These two innovations are respectively non-trivial generalizations of the notions of commutator fully transitive and strongly commutator fully transitive p-groups from a paper of Chekhlov and Danchev (J. Group Theory, 2015). They are also commutator socle-regular in the sense of Danchev and Goldsmith (J. Group Theory, 2014). Various results from there and from a paper of Goldsmith and Strüngmann (Houston J. Math., 2007) are considerably extended to this new point of view.
We also define and explore the concept of a commutator weakly transitive Abelian p-group, comparing its properties with those of the aforementioned two group classes. Some affirmations, sounding quite curiously, are detected in order to illustrate the pathology of the commutators in the endomorphism rings of p-primary Abelian groups.
Metric geometry of infinite-dimensional Lie groups and their homogeneous spaces
Authors: Larotonda Gabriel 
Published: September 2019

Abstract
We study the geometry of Lie groups G with a continuous Finsler metric, in presence of a subgroup K such that the metric is right-invariant for the action of K. We present a systematic study of the metric and geodesic structure of homogeneous spaces M obtained by the quotient

M
≃

G
/
K

{M\simeq G/K}

. Of particular interest are left-invariant metrics of G which are then bi-invariant for the action of K. We then focus on the geodesic structure of groups K that admit bi-invariant metrics, proving that one-parameter groups are short paths for those metrics, and characterizing all other short paths. We provide applications of the results obtained, in two settings: manifolds of Banach space linear operators, and groups of maps from compact manifolds.
Simulation of Particle Mixing and Separation in Multi-Component Fluidized Bed Using Eulerian-Eulerian Method: A Review
Authors: Zhang Yong , Ran Zhenzhen , Jin Baosheng , Zhang Youwei , Zhou Chunlei , Sher Farooq 
Published: September 2019

Abstract
In practical engineering applications, the mixing and separation behavior of multi-component particles is importance to the fluidized bed operation. The development of many practical processes is inseparable from the knowledge of particle mixing and separation, such as material processing of ash-soluble coal gasification, multi-phase flow in boilers, and petrochemical catalytic processes. In recent years, due to the obvious advantages of the Eulerian–Eulerian model, many researchers at home and abroad have used it to study the mixing and separation behavior of particles. The paper reviews the use of Eulerian–Eulerian model to study the mixing and separation of multi-component particles in fluidized beds. The Eulerian–Eulerian model describes the gas-phase and each of the individual particles as continuums. The mechanism of particle mixing and separation, the influence of different factors on the particle mixing and separation including differences in particle size and density, the differences in apparent air velocity, the differences in model factors are discussed. Finally, an outlook for the use of Eulerian–Eulerian model to study the mixing and separation behavior of three component particles and related research on the drag model between particles.