bluuebunny/crossref_metadata_2025_split huggingface dataset:
Target oxygen saturation and development of pulmonary hypertension and increased pulmonary vascular resistance in preterm infants
Authors: Laliberté Corinne , Hanna Youstina , Ben Fadel Nadya , Lemyre Brigitte , Bijelic Vid , Barrowman Nicholas , Hoey Lynda , Thébaud Bernard , Katz Sherri L. 
Published: November 2018

AbstractObjectiveDetermine whether higher targeted oxygen levels are associated with reduced incidence of pulmonary hypertension (PH) and elevated pulmonary vascular resistance (PVR) in extremely premature infants.Study designRetrospective chart review of 252 extremely preterm infants (<29 weeks), who underwent echocardiogram prior to discharge. PH rates were compared during periods (June 2012‐May 2015 and June 2015‐April 2016) when lower (88‐92%) or higher (90‐95%) oxygen saturation targets were used. PH was determined on echocardiography. The ratio of pulmonary artery acceleration time to right ventricular ejection time was computed, with values <0.31 indicative of elevated PVR. Survival analysis compared the effects of oxygen saturation group on development/resolution of PH and elevated PVR.ResultsThe higher saturation group had significantly lower risk of developing PH (hazard ratio (HR) = 0.50, 95%CI 0.26‐0.95; P = 0.03) or elevated PVR (HR = 0.55, 95%CI 0.38‐0.81; P = 0.002), compared to the lower oxygen saturation group. Median time to PH development was significantly shorter in the lower saturation group than in the higher saturation group (5 days vs 12 days; P = 0.02), as was time to development of elevated PVR (4 days vs 6 days; P < 0.001). Duration of PH (P = 0.12) and elevated PVR (P = 0.86) did not differ significantly between groups. Cumulative incidence of PH (P = 0.04) and elevated PVR (P = 0.01) at 36 weeks post‐menstrual age was significantly lower in the high saturation group compared to the lower saturation group.ConclusionHigher targeted oxygen saturation was associated with reduced risk of PH or elevated PVR in extremely preterm infants compared to lower oxygen saturation target.
Repellence of Myzus persicae (Sulzer): evidence of two modes of action of volatiles from selected living aromatic plants
Authors: Dardouri Tarek , Gautier Hélène , Ben Issa Refka , Costagliola Guy , Gomez Laurent 
Published: November 2018

AbstractBACKGROUNDIntercropping companion plants (CPs) with horticultural crops could be an eco‐friendly strategy to optimize pest management. In this research, volatile organic compounds (VOCs) emitted by some CPs were investigated for their repellent properties towards the green peach aphid (Myzus persicae Sulzer). The aim of this study was to understand the modes of action involved: direct effects on the aphid and/or indirect effects via the host plant (pepper, Capsicum annuum L.).RESULTSWe identified two promising repellent CP species: the volatile blend from basil (Ocimum basilicum, direct repellent effect) and the mixture of (or previously intercropped) C. annuum plants with Tagetes patula cv. Nana (indirect effect). This effect was cultivar‐dependent and linked to the volatile bouquet. For the 16 compounds present in the O. basilicum or T. patula bouquets tested individually, (E)‐β‐farnesene, and eugenol reported good repellent properties against M. persicae. Other compounds were repellent at medium and/or highest concentrations. Thus, the presence of repellent VOCs in a mixture does not mean that it has a repellent propriety.CONCLUSIONWe identified two promising repellent CP species towards M. persicae, with a likely effect of one CP's VOCs on the host plant repellency and highlighted the specific effectiveness of VOC blends. © 2018 Society of Chemical Industry
Problems of reproductive function in survivors of childhood‐ and adolescent and young adult‐onset cancer revealed in a part of a national survey of Japan
Authors: Furui Tatsuro , Takai Yasushi , Kimura Fuminori , Kitajima Michio , Nakatsuka Mikiya , Morishige Ken‐ichiro , Higuchi Akiko , Shimizu Chikako , Ozawa Miwa , Ohara Akira , Tatara Ryohei , Nakamura Terukazu , Horibe Keizo , Suzuki Nao 
Published: November 2018

AbstractPurposeThis study aimed to evaluate the current status of reproductive disorders as long‐term complications in adolescent and young adult (AYA) cancer patients by comparing survivors of childhood‐onset with those of AYA‐onset cancer in Japan.MethodsWe conducted a national survey of AYA cancer survivors and healthy AYAs and analyzed the results from survivors who underwent chemotherapy and reported fertility problems as their current concern.ResultsAmong all of the childhood‐onset survivors, 27 (35.5%; nine males [28.1%] and 18 females [40.9%]) listed reproduction fertility problems as their current concern. Among all AYA‐onset survivors, 25 (69.5%; 1/4 males [25.0%] and 24/32 females [75.0%]) listed these problems as a current concern. In contrast, 96.3% (26/27) of all childhood‐onset cancer survivors and 68.0% (17/25) of all AYA‐onset cancer survivors who received chemotherapy listed these problems as a current concern.ConclusionsA considerable number of both childhood‐onset and AYA‐onset cancer survivors, and especially those who had undergone chemotherapy, reported reproductive dysfunction as a delayed complication. It is vitally important to establish a supportive care system both for the patients whose fertility was abolished after the completion of cancer treatment and prophylactically for patients before they begin treatment.
Output‐feedback control strategies of lower‐triangular nonlinear nonholonomic systems in any prescribed finite time
Authors: Chen Xiandong , Zhang Xianfu 
Published: November 2018

SummaryIn this paper, output‐feedback control strategies are proposed for lower‐triangular nonlinear nonholonomic systems in any prescribed finite time. Specifically, by employing the input‐state–scaling technique, the controlled systems are firstly converted into lower‐triangular nonlinear systems, which makes it possible to study such systems using the high‐gain technique. Then, by introducing a scaling of the state by a function that grows unbounded toward the terminal time and proposing a high‐gain observer–prescribed finite time recovering the system states, the output‐feedback regulation control problem in any prescribed finite time is firstly achieved for nonlinear nonholonomic systems with unknown constant incremental rate. Moreover, by designing another time‐varying high gain, the output‐feedback stabilization control problem in any prescribed finite time is then achieved for nonlinear nonholonomic systems with a time‐varying incremental rate. Finally, a numerical example is introduced to show the effectiveness of proposed control strategies.
Security analysis for cyber‐physical systems under undetectable attacks: A geometric approach
Authors: Zhao Zhengen , Yang Ying , Li Yuzhe , Liu Ruijie 
Published: November 2018

SummaryIn this paper, the security issues of cyber‐physical systems under undetectable attacks are studied. The geometric control theory is used to investigate the design, implementation, and impact evaluation of undetectable attacks. First, a feedforward‐feedback structure for undetectable attacks is proposed, which provides a designable form for an attack to be undetectable. The corresponding attack strategy is designed via pole placement in the weakly unobservable subspace of the attacked system. Then, the security analysis of several common undetectable attacks injected from actuators, sensors, and the coordinated of the two is discussed. Finally, the simulations on the quadruple‐tank process demonstrate the effectiveness of the proposed methods.
Effect of Lithiation Voltage Limit on the Electrochemical Performance of High Surface Area Anatase TiO2 Nanoparticles and Its Application in Full‐Cell Li–Ion Battery
Authors: Gangaja Binitha , Jayasree Silpasree S. , Nair Shantikumar , Santhanagopalan Dhamodaran 
Published: November 2018

AbstractTitania based anodes have received considerable interest due to its cycling stability and improved safety. Here, we report the electrochemical performance of high surface area anatase TiO2 nanoparticles synthesized via solvothermal technique. Prepared anatase TiO2 nanoparticles were below 15 nm in average particle size exhibiting high surface area of 251 m2/g and titanium existing in 4+ oxidation state. The electrodes studied by limiting the discharge voltage between 1.0 V and 0.01 V showed significant performance differences. Especially, specific capacity, Coulombic efficiency and storage mechanism of TiO2 depends strongly on lithiation voltage cut‐off limit that is discussed in detail. It was established that discharging to 1.0 V showed better performance hence, subsequent studies the lithiation (discharge) was limited to 1.0 V. High rate capability of the electrodes were tested test up to 60 C and long cycle stability up to 1000 cycles (at 10 C rate). As an energy storage solution, a 2.0 V full‐cell Li‐ion battery was fabricated with the TiO2 nanoparticles as anode against surface modified LiCoO2 as cathode. The full‐cell delivered specific capacities about 165 mAh/g and 105 mAh/g at current densities of 150 mA/g and 3765 mA/g respectively. It also exhibited 126 mAh/g capacity and 85% retention at the end of 100 cycles at a current density of 1000 mA/g. The full‐cell delivered a maximum power density of 5.5 kW/kg and a corresponding energy density of 185 Wh/kg.
Synthesis of Novel Benzothiazolo[3,2‐a]pyridimidin‐4‐ones with Potential Cytotoxic and Pro‐Apoptotic Potential
Authors: Jafari Behzad , Rashid Faisal , Safarov Sayfidin , Ospanov Meirambek , Yelibayeva Nazym , Abilov Zharylkasyn A. , Turmukhanova Mirgul Z. , Kalugin Sergey N. , Ehlers Peter , Umar Muhammad Ihtisham , Zaib Sumera , Iqbal Jamshed , Langer Peter 
Published: November 2018

AbstractThe combination of cyclocondensation with palladium catalysed cross‐coupling reactions, afforded a variety of 8‐functionalized benzothiazolo[3,2‐a]pyridimidin‐4‐ones in good to excellent yields. The anti‐proliferative potential of the synthetic compounds was evaluated in human cervical adenocarcinoma cells (HeLa) and hamster normal fibroblasts (BHK‐21). Three of the test derivatives exhibited the strongest cytotoxicity in HeLa cells with the median inhibitory concentration (IC50) of 0.93, 1.55 and 1.84 μM, respectively. Moreover, their anti‐proliferative effect was three times less strong in normal fibroblasts, asserting their possible anti‐cancer potential.
Copper Incorporation in Organic‐Inorganic Hybrid Halide Perovskite Solar Cells
Authors: Song Zhen , Jiang Yidong , Liu Jiang , Pan Qifa , Zuo Wentao , Zhang Xu , Liao Cheng , Mei Jun 
Published: November 2018

AbstractThe organic‐inorganic hybrid halide perovskite solar cell with excellent photovoltaic performance has been considered a promising device in photovoltaic field. By element substitution in perovskites, the crystal structure and properties of materials can be altered. Herein, two copper‐based compounds are used as additives in perovskites, which affect the crystallization process of perovskite films, and modify the photoelectric properties of perovskite materials. It is found that an appropriate addition of copper (Cu) ions could not only reduce the perovskite phase transition temperature, promote the formation of black perovskite phase, but also improve the crystallization and absorbance of perovskites. Excessive Cu incorporation leads to significant loss of device performance. The appropriate concentration of Cu ions in perovskite absorber for high efficiency solar cell is considered to be ∼0.1 mol% from a number of experimental results, which contributes to a remarkable stability of the device with only 2% power conversion efficiency loss after 170 h. This study is conducive to the comprehensive understanding of the effect of ions doping in perovskite materials.
Perceived stress mediates the relationship between mindfulness and negative affect variability: A randomized controlled trial among middle‐aged to older adults
Authors: Colgan Dana Dharmakaya , Klee Daniel , Memmott Tab , Proulx Jeffrey , Oken Barry 
Published: November 2018

AbstractDespite the interest in mindfulness over the past 20 years, studies have only recently begun to examine mindfulness in older adults. The primary aim of this study was to evaluate pretreatment to post‐treatment change in negative affect variability (NAV) following a mindfulness training among 134 mildly stressed, middle‐aged to older adults. The secondary aim was to assess if the effects of mindfulness training on NAV would be partially explained by pretreatment to post‐treatment reductions in perceived stress, a trend that would be congruent with several stress models. In this randomized control trial, participants were assigned to either a 6‐week mindfulness meditation training programme or to a wait list control. Ecological momentary assessment, a data capturing technique that queries about present moment experiences in real time, captured NAV. Mixed‐model ANOVAs and a path analysis were conducted. Participants in the mindfulness meditation training significantly reduced NAV when compared with wait list control participants. Further, there was a significant indirect group effect on reductions in NAV through change in perceived stress. Few studies have tested mechanisms of action, which connect changes that occur during mindfulness training with psychological outcomes in older adults. Understanding the mechanisms by which mindfulness enhances well‐being may optimize interventions.
Single Domain 10 nm Ferromagnetism Imprinted on Superparamagnetic Nanoparticles Using Chiral Molecules
Authors: Koplovitz Guy , Leitus Gregory , Ghosh Supriya , Bloom Brian P. , Yochelis Shira , Rotem Dvir , Vischio Fabio , Striccoli Marinella , Fanizza Elisabetta , Naaman Ron , Waldeck David H. , Porath Danny , Paltiel Yossi 
Published: November 2018

AbstractThe rapid growth in demand for data and the emerging applications of Big Data require the increase of memory capacity. Magnetic memory devices are among the leading technologies for meeting this demand; however, they rely on the use of ferromagnets that creates size reduction limitations and poses complex materials requirements. Usually magnetic memory sizes are limited to 30–50 nm. Reducing the size even further, to the ≈10–20 nm scale, destabilizes the magnetization and its magnetic orientation becomes susceptible to thermal fluctuations and stray magnetic fields. In the present work, it is shown that 10 nm single domain ferromagnetism can be achieved. Using asymmetric adsorption of chiral molecules, superparamagnetic iron oxide nanoparticles become ferromagnetic with an average coercive field of ≈80 Oe. The asymmetric adsorption of molecules stabilizes the magnetization direction at room temperature and the orientation is found to depend on the handedness of the chiral molecules. These studies point to a novel method for the miniaturization of ferromagnets (down to ≈10 nm) using established synthetic protocols.
Promoting Nitrogen Electroreduction on Mo2C Nanoparticles Highly Dispersed on N‐Doped Carbon Nanosheets toward Rechargeable Li–N2 Batteries
Authors: Wang Xin‐Gai , Zhang Qinming , Zhang Xin , Wang Chengyi , Xie Zhaojun , Zhou Zhen 
Published: November 2018

AbstractN2 fixation is a challenging and rewarding issue. However, the traditional Haber–Bosch process consumes a large amount of fossil fuels, resulting in serious environmental pollution. Instead, N2 electroreduction is a promising way to convert and utilize N2. Among various N2 electroreduction methods, combining N2 reduction with batteries is simple and efficient. Here, a composite of ultrasmall Mo2C particles highly dispersed on N‐doped carbon nanosheets is prepared, and it is applied as the air cathode for Li–N2 batteries. Li–N2 batteries show high discharge capacity and superior reversibility, demonstrating that the Li–N2 battery is a promising platform for N2 electroreduction and electrochemical energy storage.
Determination of Ethofumesate‐2‐hydroxy Stereolability by Dynamic HPLC
Authors: Perovani Icaro Salgado , de Oliveira Anderson Rodrigo Moraes 
Published: November 2018

AbstractEvaluating stereolability of target chiral chemical is pivotal when developing enantioselective studies. Ethofumesate‐2‐hydroxy is one of the main metabolites of ethofumesate, a chiral herbicide currently marketed as racemate. In order to perform enantioselective pharmacokinetic and metabolism studies, the stereolability of susceptible molecules should be evaluated. Based on that, dynamic high‐performance liquid chromatography experiments were performed to evaluate ethofumesate‐2‐hydroxy enantiomerization process on‐column. The thermodynamic results helped understand that ethofumesate‐2‐hydroxy enantiomerization is a bimolecular process assisted by acid and base catalysis. The enantiomerization barrier determined suggested that ethofumesate‐2‐hydroxy single enantiomers may undergo extensive racemization at ambient temperature turning ethofumesate‐2‐hydroxy enantioselective studies into an unfeasible task.
Emissive Iridium(III) Complexes with Phosphorous‐Containing Ancillary
Authors: Chi Yun , Wang Sheng Fu , Ganesan Paramaguru 
Published: November 2018

AbstractIr(III) metal complexes and related emitters bearing all kind of cyclometalated chromophoric chelates and non‐chromophoric ancillary are extensively studied during the past three decades. Many of them have been found to display bright room temperature phosphorescence from triplet excited states in both solution and solid states, offering a possible application in contemporary optoelectronic technologies, including organic light emitting diodes, electrochemiluminescence, biological imaging and chemical sensing. Among reported materials, there are Ir(III) complexes with at least one phosphorus (P)‐containing ligand and/or ancillary chelate, together with cyclometalates or equivalents that are in control of the actual emission energy. Particularly, possession of P‐based donor can lead to divergent structural and photophysical properties compared to the traditional designs. This review aims to provide a literature overview as well as the authors’ personal account to the development of relevant Ir(III) based phosphors bearing these P‐donors. To the readers’ convenience, the contents are subdivided into six sessions, according to whether or not they are charge natural, or with mono‐ or dianionic electronic character, and in accordance to their divergent bonding modes, i. e. monodentate, bidentate and tripodal coordination. In many cases, the P‐based ancillaries offer an easy accessible route to the formation of efficient sky‐blue and true‐blue emitters due to their π‐accepting property, together with enlarged emission energy gap and destabilized upper lying quenching state.
Para‐tertiary butyl catechol (PTBC), an industrial antioxidant induces human platelet apoptosis
Authors: Vishalakshi Gopalapura J. , NaveenKumar Somanathapura K. , Hemshekhar Mahadevappa , Mahendra Madegowda , Kemparaju Kempaiah , Girish Kesturu S. 
Published: November 2018

AbstractThe catecholic derivative para‐tertiary butyl catechol (PTBC) is a conventional antioxidant and polymerization inhibitor, which exhibits melanocytotoxic effects and contact dermatitis often leading to occupational leucoderma or vitiligo. Although numerous industrial workers will be in constant exposure to PTBC and its chances of getting entry into blood are most expected, its effect on blood components is still undisclosed. As platelets play a prominent role in dermatitis, inflammation, and immunity, in this study we have evaluated the effect of PTBC on human platelets in vitro. Exposure of platelets to PTBC showed increased reactive oxygen species (ROS), intracellular calcium, cardiolipin oxidation, mitochondrial permeability transition pore(MPTP) formation, activation of caspases, phosphatidylserine (PS) externalization and decreased mitochondrial membrane potential. In addition, there was a significant decrease in cellular glutathione level, increased γ‐glutamyltransferase (GGT) activity and cell death. These findings demonstrate that PTBC could induce toxic effects on blood components, which is often ignored field of research. Since dermal exposure of humans to toxic chemicals covers an important issue in various industries, there is a need of such work to understand and update the long‐term toxicities induced by PTBC usage in industrial sectors and public domain.
Deep learning enables automatic quantitative assessment of puborectalis muscle and urogenital hiatus in plane of minimal hiatal dimensions
Authors: van den Noort F. , van der Vaart C. H. , Grob A. T. M. , van de Waarsenburg M. K. , Slump C. H. , van Stralen M. 
Published: November 2018

ABSTRACTObjectivesTo measure the length, width and area of the urogenital hiatus (UH), and the length and mean echogenicity (MEP) of the puborectalis muscle (PRM), automatically and observer‐independently, in the plane of minimal hiatal dimensions on transperineal ultrasound (TPUS) images, by automatic segmentation of the UH and the PRM using deep learning.MethodsIn 1318 three‐ and four‐dimensional (3D/4D) TPUS volume datasets from 253 nulliparae at 12 and 36 weeks' gestation, two‐dimensional (2D) images in the plane of minimal hiatal dimensions with the PRM at rest, on maximum contraction and on maximum Valsalva maneuver, were obtained manually and the UH and PRM were segmented manually. In total, 713 of the images were used to train a convolutional neural network (CNN) to segment automatically the UH and PRM in the plane of minimal hiatal dimensions. In the remainder of the dataset (test set 1 (TS1); 601 images, four having been excluded), the performance of the CNN was evaluated by comparing automatic and manual segmentations. The performance of the CNN was also tested on 117 images from an independent dataset (test set 2 (TS2); two images having been excluded) from 40 nulliparae at 12 weeks' gestation, which were acquired and segmented manually by a different observer. The success of automatic segmentation was assessed visually. Based on the CNN segmentations, the following clinically relevant parameters were measured: the length, width and area of the UH, the length of the PRM and MEP. The overlap (Dice similarity index (DSI)) and surface distance (mean absolute distance (MAD) and Hausdorff distance (HDD)) between manual and CNN segmentations were measured to investigate their similarity. For the measured clinically relevant parameters, the intraclass correlation coefficients (ICCs) between manual and CNN results were determined.ResultsFully automatic CNN segmentation was successful in 99.0% and 93.2% of images in TS1 and TS2, respectively. DSI, MAD and HDD showed good overlap and distance between manual and CNN segmentations in both test sets. This was reflected in the respective ICC values in TS1 and TS2 for the length (0.96 and 0.95), width (0.77 and 0.87) and area (0.96 and 0.91) of the UH, the length of the PRM (0.87 and 0.73) and MEP (0.95 and 0.97), which showed good to very good agreement.ConclusionDeep learning can be used to segment automatically and reliably the PRM and UH on 2D ultrasound images of the nulliparous pelvic floor in the plane of minimal hiatal dimensions. These segmentations can be used to measure reliably UH dimensions as well as PRM length and MEP. © 2018 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.