bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Biological Evaluation of Isofebrifugine Analogues
Authors: Zhang Jinjin , Huang Baohua , Lu Yujing , Li Wenbin , Zhuang Zichong , Ke Donghua , Zhong Jingpeng , Zhou Jinlin , Chen Qian 
Published: April 2019

:
Isofebrifugine, as a kind of natural quinazolinone alkaloid with important physiological activities
and good pharmacological effects, was isolated from a Chinese medicinal plant, Chang Shan
(Dichroa febrifuga). In this paper, the synthesis of a series of novel isofebrifugine analogues was accomplished
by employing the N-alkylation of 4(3H)-quinazolinones with benzyl (3aR,7aR)-rel-2-
(bromomethyl)hexahydrofuro[3,2-b]pyridine-4(2H)carboxylates and the subsequent N-deprotection.
These analogues were characterized by 1H NMR, 13C NMR and HRMS spectra. The MTT assay was
used to examine the inhibitory effects of these analogues on the growth of human hepatoma cells
(HepG2). The results indicated that some halogenated or hemiketal analogues showed interesting inhibition
activity.
A Cytotoxic Natural Product from Patrinia villosa Juss
Authors: Liu Yangcheng , Liu Wei , Chen Changlan , Xiang Zheng , Liu Hongwei 
Published: April 2019

Background and Purpose::
Patrinia villosa Juss is an important Chinese herbal medicine widely used
for thousands of years, but few reports on the ingredients of the herb have been presented. In this study, we aim
to isolate the bioactive compound from the plant.

Material and Methods::
The air-dried leaves of P. villosa (15kg) were extracted three times with 70% EtOH
under reflux. The condensed extract was suspended in H2O and partitioned with light petroleum,
dichloromethane and n-BuOH. The dichloromethane portion was then subjected to normal-phase silica gel
column chromatography, ODS silica gel column chromatography and semi-preparative HPLC to yield
compound 1. Cytotoxicities of 1 were assayed on HepG2, A549 and A2780 cell lines. The mechanism of
apoptosis and cell cycle on A549 was confirmed subsequently.

Results:
A new impecylone (Impecylone A) was isolated from the leaves of Patrinia villosa Juss, and its
structures were established using 1D, 2D-NMR spectra and HR-ESI-MS. Impecylone A could selectivity inhibit
HepG2 and A549 cell lines. The compound could induce apoptosis of A549 and arrest the cell cycle at G2/M
phase in a dose-dependent manner.

Conclusion:
Impecylone A is a novel compound from Patrinia villosa Juss and could be a potential antitumor
agent especially in the cell lines of A549.
Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves
Authors: Bouallagui Zouhaier , Mahmoudi Asma , Maalej Amina , Hadrich Fatma , Isoda Hiroko , Sayadi Sami 
Published: April 2019

Aim:This study was designed to investigate the phytochemical profile and the cytotoxic activities of the eco-friendly extracts of olive leaves from Chemlali cultivar.Materials and Methods:The Phenolic composition of olive leaves extracts, the antioxidant activity and the cytotoxic effects against MCF-7 and HepG2 cells were determined.Results:Olive leaves extracts showed relevant total polyphenols contents. Oleuropein was the major detected phenolic compound reaching a concentration of 16.9 mg/ml. The antioxidant potential of the studied extracts varied from 23.7 to 46.5mM Trolox equivalents as revealed by DPPH and ABTS assays. Cytotoxicity experiments showed similar trends for both HepG2 and MCF-7 cells with the infusion extract being the most active.Conclusion:This study denotes that olive leaves may have great potential as endless bioresource of valuable bioactive compounds which may have a wide application.
Bevacizumab Allows Preservation of Liver Function and its Regenerative Capacity after Major Hepatectomy
Authors: Valverde Amparo , Ciria Rubén , Caballero-Villarraso Javier , Aguilar-Melero Patricia , Ferrín Gustavo , Ranchal Isidora , Linares Clara , Herencia Carmen , González-Rubio Sandra , de la Mata Manuel , Naranjo Álvaro , Briceño Javier 
Published: April 2019

Background:
Parallel to the safety of liver resections, new chemotherapy drugs have emerged for the
control of liver metastases. However, there is unclear evidence about the combination of intensive BVZ-therapy
and extended resections. The main aim was to analyse the impact of Bevacizumab (BVZ) in terms of liver safety
and tolerability in two experimental models: a basal-toxicity situation and after major hepatectomy.

Methods:
Eighty male-Wistar rats were grouped as toxicity analysis (sham-operated rats-OS-) and regenerationafter-
surgery analysis (hepatectomy rats-H-). Eight further subgroups were created according to sacrifice (6-
hours-6h- or 24-hours-24h-) and dose (μg) of BVZ (none, 100, 200, 400). Several measurements were performed,
including biochemical serum samples, histopathological analysis, cytokines (IL-6, TNF-α, TGF-β),
oxidative-stress (GSH/GSSG, ATP), lipid-peroxidation (TBARS) and epidermal and vascular endothelium
growth-factors (EGF and VEGF).

Results:
In the toxicity analysis, safe results with BVZ were observed, with no significant differences among the
groups. A trend towards a lower oxidative status was observed in the OS 6 h-100, -200 and -400 versus the OS 6
h-none group. Similar results were observed in the hepatectomy model, with stable oxidative-stress-index and
IL-6, TNF- α, and TGF- β levels. Despite higher lipid peroxidation status, overall regeneration was preserved.
As expected, VEGF was almost undetectable in BVZ-treated groups after resection, but not in the non-resection
group.

Conclusion:
It was concluded that liver status was not impaired by BVZ even at the high-dose. Similarly, liver
regeneration after extended hepatectomy in BVZ-treated animals was well-preserved. Extended liver resections
may be encouraged in BVZ-treated patients due to its excellent tolerability and good liver regeneration status.
Characterization and Classification of Soils of a Toposequence in a Derived Savannah Agroecological Zone of Nigeria
Authors: Adegbite Kehinde A. , Okafor Millicent E. , Adekiya Aruna O. , Alori Elizabeth T. , Adebiyi Ojo T. V. 
Published: April 2019

Background:Soil properties are anisotropic in nature, hence the need to study soil associations and regional landscapes for sustainable nutrient management and soil profile is an important tool which can be utilized for this purpose.Objective:The objectives of the study are to describe the morphology of the soils of the toposequence, determine their physical and chemical properties, classify them and make an appraisal of their agricultural potentials.Methods:Three slope classes were considered and a total of three profile pits, one on each slope were studied and described in the field morphologically at Eleyin Farms Omu-Aran, Kwara State, Nigeria, which was a newly opened up plantation.Samples of soil were collected from the horizons of the profile pits. The soil samples were analyzed for their physical and chemical properties.Results:All the three pedons showed appreciable differences in physical, chemical, and morphological characteristics of the soils and their classifications were determined as guided by their characteristics. The textural classes were defined mainly by the sand compositions which decreased from the upper and middle slopes down to the bottom slope, and the clay compositions which increased progressively from the uppermost slope through the middle slope to the bottom slope. Silt compositions did not exhibit any particular pattern.Conclusion:Thus, sand and clay compositions were more significant and relevant to the textural classification of the soils of the area than silt. The low nutrient status of the soils can be ameliorated by incorporation of organic or farm residues to increase the organic matter content of the soil, and also improve management practices and guided chemical fertilizer use. The soils of the area were classified as Typic Haplustalf (USDA), and Ferric Luvisol (FAO).
Recent Advances in Curcumin Nanocarriers for the Treatment of Different Types of Cancer with Special Emphasis on In Vitro Cytotoxicity and Cellular Uptake Studies
Authors: Sharma Jai B. , Bhatt Shailendra , Sharma Asmita , Kumar Manish 
Published: April 2019

Background:
The potential use of nanocarriers is being explored rapidly for the targeted
delivery of anticancer agents. Curcumin is a natural polyphenolic compound obtained from
rhizomes of turmeric, belongs to family Zingiberaceae. It possesses chemopreventive and chemotherapeutic
activity with low toxicity in almost all types of cancer. The low solubility and bioavailability
of curcumin make it unable to use for the clinical purpose. The necessity of an effective
strategy to overcome the limitations of curcumin is responsible for the development of its nanocarriers.

Objective:
This study is aimed to review the role of curcumin nanocarriers for the treatment of
cancer with special emphasis on cellular uptake and in vitro cytotoxicity studies. In addition to
this, the effect of various ligand conjugated curcumin nanoparticles on different types of cancer
was also studied.

Methods:
A systematic review was conducted by extensively surfing the PubMed, science direct
and other portals to get the latest update on recent development in nanocarriers of curcumin.

Results:
The current data from recent studies showed that nanocarriers of curcumin resulted in the
targeted delivery, higher efficacy, enhanced bioavailability and lower toxicity. The curcumin
nanoparticles showed significant inhibitory effects on cancer cells as compared to free curcumin.

Conclusion:
It can be concluded that bioavailability of curcumin and its cytotoxic effect to cancer
cells can be enhanced by the development of curcumin based nanocarriers and it was found to be a
potential drug delivery technique for the treatment of cancer.
Using Technology to Facilitate Fidelity Assessments: The Tele-STAR Caregiver Intervention
Authors: Lindauer Allison , McKenzie Glenise , LaFazia David , McNeill Loriann , Mincks Kate , Spoden Natasha , Myers Marcella , Mattek Nora , Teri Linda L 
Published: April 2019

Background
Families living with Alzheimer disease and related dementias have more access to support thanks to the development of effective telehealth-based programs. However, as technological science grows, so does the risk that these technology-based interventions will diverge from foundational protocols, diluting their efficacy. Strategies that ensure programs are delivered as intended, with fidelity to guiding protocols, are needed across the intervention spectrum—from development to wide-scale implementation. Few papers address fidelity in their technology-based work. Here, we present our translated telehealth intervention, Tele-STAR, with our fidelity findings.

Objective
This study aimed to assess the preliminary efficacy of Tele-STAR on reducing family caregiver burden and depression. Across the implementation phases, we assessed the fidelity of a caregiver education intervention, STAR-C, as it was translated into a telehealth option (Tele-STAR).

Methods
A total of 13 family caregivers consented to participate in an 8-week, videoconference-based intervention (Tele-STAR). Tele-STAR efficacy in reducing the affective burden of caregiving was assessed using pre- and postintervention paired t tests. Content experts assessed program fidelity by reviewing and rating Tele-STAR materials for adherence to the original STAR-C protocol. These experts assessed treatment fidelity by viewing videos of the intervention and rating adherence on a checklist.

Results
Tele-STAR reduced caregiver burden and retained good program and treatment fidelity to STAR-C.

Conclusions
We found Tele-STAR reduced caregiver burden and had good fidelity to the original protocol. Assessing fidelity is a complex process that requires incorporation of these procedures early in the research process. The technology used in this study facilitated the accrual of informative data about the fidelity of our translated intervention, Tele-STAR.
»Monitor Yourself!« The Controlled Emotions of Spanish Office Holders in the Early Modern Period
Authors: Brendecke Arndt 
Published: April 2019

Abstract
The essay is dedicated to the idealized emotionlessness of early modern Spanish office holders. It focuses on the so called corregidores, which represented the king and administered justice in major Spanish cities. Their instructions often idealized the total lack of pasiones or at least their complete invisibility. Such a discarding of all affects echoed the ideals of impartial judges, just kings and uninterested clerics and had specific functions, especially in cities with their high density of mutual observation. To live accordingly, that is, with one’s own emotions permanently held in check, required personal aptitude, appropriate age and a process of education and study which should convert certain habits into a ›second nature‹ and thus distinguish the corregidor significantly from the society over which he was to judge. Constantly checked by society however, this second nature would corrupt, if not protected by a rigid and permanent »vigilance over oneself«.
Bürgeremotionen versus Verwaltungsrationalität?
Authors: Mecking Sabine 
Published: April 2019

Abstract
Political discussions and negotiation processes are often used to classify rational or emotional behavior that enhances one’s own and the other’s devaluation. In the paper this is elaborated with a view to the clash of state planning euphoria and civic protest in the wake of the great administrative reforms of the 1960s and 1970s. Both supporting the reforms and criticizing them are highly complex emotional processes. But how is this reflected in the arguments and actions of the actors? To answer this question, the contemporary ideas and interpretations of a rational and emotional behavior come into focus. The emotions associated with the debate are analyzed at various levels: as a strategy of citizens’ initiatives, as a media strategy, as a factor of community involvement or the “emotional community” and as an attribution.
»The Long Line They Must Make in the Night«: Performative Realism in the Italian State’s Relations with Outsiders
Authors: Garot Robert 
Published: April 2019

Abstract
This article provides a first-hand account of waiting in line to deliver migration documents at an office of the police department known as the Questura in Italy, in 2006. The spectacle of migrants suffering in line day after day, subjected to threats from police and the jostling, complaints and aggression of others in line, provided a stage for the performative realism of the widescale exclusion, criminalization and scapegoating of migrants in Italy at the time. Moreover, migrants’ relations to the state and Italians’ relations to migrants were embodied and felt through the line, marked on bodies and in memories as visceral marginalization.
Numerical Solutions with Linearization Techniques of the Fractional Harry Dym Equation
Authors: Yokuş Asıf , Gülbahar Sema 
Published: April 2019

Abstract
In this study, numerical solutions of the fractional Harry Dym equation are investigated. Linearization techniques are utilized for non-linear terms existing in the fractional Harry Dym equation. The error norms L
2 and L
∞ are computed. Stability of the finite difference method is studied with the aid of Von Neumann stabity analysis.
Impact of Leverage and Risk Exposure on Financial Performance in SMEs of Northern Punjab
Authors: Iqbal Javed , Sandhu Moeed Ahmad , Ahmad Zubair , Javed Muhammad Hamza , Ali Waris 
Published: April 2019

Basic objective of this research was to discover the impact of Leverage on Risk and Profitability. For this purpose main focus of research was SMEs and Commercial sector of Pakistan. Leverage has three types DOL, DFL and DTL. And these three types of leverage are independent variables for this research while dependent variables of this research are ROE, ROA, ROS, GM and Risk. Further sales growth is also used as control variable in this research. Time frame for data analysis was 3 years from 2012 to 2014. Sample size for this research is 61 SMEs and Commercial sector organizations.
Secondary data was used in this research and data was collected by using different data collection methods. SPSS version 20 was used to analyze data. Linear regression analyses were used to check the significant relationship between independent variables and dependent variables.
This research is limited to just SMEs and Commercial sector organization so we cannot use these results for overall industry or sectors. This research is entirely new research for SMEs and Commercial sector organizations.
Some Biological Aspects of Al - Shabbot Arabibarbus grypus (Heckel, 1843) in Al-Diwanyia River, Middle of Iraq
Authors: Abdullah Al-Jubouri Mohanad O. , Mohamed Abdul-Razak M. 
Published: April 2019

Some biological characteristics of shabbot, Arabibarbus grypus (Heckel, 1843) in the Al-Diwaniya River, middle of Iraq were studied from October 2016 to September 2017. Water temperature ranged from 10.2oC in March to 32.8oC in August. A total of 853 fish were caught by seine, gill and cast nets and electro-fishing. A. grypus constituted about 6.27% of the total fish catch. The length-weight relationship was W=0.021*L2.7548 revealing an allometric growth. The mean relative condition factor was 0.91. Five age groups wore recorded and their mean total lengths were 20.2, 32.0, 39.0, 43.9 and 48.4 cm, respectively. The growth model of the species was Lt= 58 [1-e -0.39 (t-0.313)]. The growth performance index (Φ) of A. grypus was computed as 3.11. The study declares that the species is a omnivore, feeding mainly on aquatic plants, insects, algae and detritus. The overall sex ratio (female: male) was 1.47:1. The highest values of gonado- somatic index (GSI) were 4.20 for female and 1.78 for males in April. The fecundity of the species ranged from 75600 to 124200 eggs.
ANALISIS PENGARUH CUSTOMER EXPERIENCE TERHADAP MINAT BERKUNJUNG KEMBALI (REVISIT INTENTION) PADA DESTINASI WISATA KOTA BOGOR
Authors: Yuningsih Erni , . Hardiansyah 
Published: April 2019

Tujuan Penelitian adalah untuk mengetahui: 1) gambaran customer experience pada destinasi wisata kota Bogor, 2) gambaran revisit intention terhadap destinasi wisata kota Bogor, 3) pengaruh customer experience terhadap minat berkunjung kembali (revisit intention) pada destinasi wisata kota Bogor. Data dikumpulkan melalui kuesioner, wawancara mendalam dan observasi. Metode analisis menggunakan analisis deskriptif, regresi berganda, uji F dan uji-t. Secara simultan variabel comfort, educational, hedonic, novelty, safety dan beauty memiliki pengaruh positif dan signifikan terhadap minat berkunjung kembali pada destinasi wisata kota Bogor. Hasil pengujian secara parsial (uji-t) menyimpulkan bahwa faktor comfort, hedonic, novelty, safety dan beauty berpengaruh positif dan signifikan terhadap minat berkunjung kembali (revisit intention), sedangkan faktor educational tidak berpengaruh. Kata Kunci : Customer Experience, Minat Berkunjung Kembali
The simulation and study of ELAP event with URG and FLEX mitigation strategies for PWR by using TRACE code
Authors: Yang J.-H. , Wang J.-R. , Shih C. , Huang C.-F. , Chen S.-W. 
Published: April 2019

Abstract
In this research, TRACE code with the interface SNAP was used to evaluate and simulate the postulated Extended Loss of AC Power (ELAP) accident in Maanshan Nuclear Power Plant (NPP). This study is to determine whether Reactor Coolant System (RCS) water level will be below Top of Active Fuel (TAF) while the 5th diesel generator and gas turbines are all disabled when the accident occurred. The scenario and assumptions of postulated ELAP in this research are referred to the WCAP-17601-Pt and NUREG-1953 reports. Additionally, this study will run a base case without any mitigation strategy and four cases with multiple mitigation strategies to analyze the effectiveness of URG and FLEX strategies. According to the analysis results of TRACE, it can be found that all four cases with mitigation strategies can keep RCS water level above TAF. This indicates that URG and FLEX strategies can ensure the safety function of reactor.
Effect of Honey/PVA Hydrogel Loaded by Erythromycin on Full-Thickness
Authors: Movassaghi Shabnam , Sharifi Zahra Nadia , Koosha Mojtaba , Abdollahifar Mohammad Amin , Fathollahipour Shahrzad , Tavakoli Javad , Abdi Shabnam 
Published: April 2019

Background: Skin wounds are a significant public health risk, and treatment of wound remains a challenging clinical problem for medical teams and researchers.Materials and Methods: In the present study, we aimed to investigate the healing effects of honey/polyvinyl alcohol (PVA) hydrogel loaded with erythromycin as wound dressing on skin wounds in rats, based on histological studies. In this study, 60 male Wistar rats, with a 1.5 ×1.5 cm2 diameter full-thickness wounds on the backs were divided into four groups: honey/PVA with the erythromycin hydrogel group, honey group, PVA group, and the control group, with no treatment. Skin biopsies were prepared at days 4, 7, and 14 for microscopic analyses. The stereological analysis, including the mean area of the wound, length of vessels, numerical density of fibroblast, macrophage, basal cell and volume of the epidermis, dermis, and fibrous tissue were performed. Result: Wounds area in the honey/PVA hydrogel with the erythromycin group were significantly (P<0.05) smaller than in the other group. The numerical density of fibroblast, macrophage, basal cell and volume of the epidermis in the honey/PVA hydrogel with the erythromycin group were significantly higher than other groups.Conclusion: According to our results, honey/PVA hydrogel with erythromycin may promote early wound healing and has a positive influence on fibroblast proliferation and re-epithelialization, and its administration is recommended after further validation of clinical data.[GMJ. 2019;8:e1362]
Chronic Suppurative Otitis Media: Bacteriology and Drug Sensitivity Patterns at the Quirino Memorial Medical Center (2004-2005): A Preliminary Study
Authors: Ayson Patricia N. , Lopez Jan Eero G. , Llanes Erasmo Gonzalo DV. 
Published: April 2019

Objectives: To identify the bacterial pathogens associated with chronic suppurative otitis media and their antimicrobial sensitivity and resistance

Study Design: Cross-sectional survey

Setting: The study was carried out from July 2004-July 2005 at the outpatient clinic of a government tertiary hospital.

Number of subjects: A total of 32 patients (54 ears) with unilateral or bilateral active chronic suppurative otitis media.

Results: Bacterial pathogens of 54 ear discharge samples from CSOM were studied. Among them, 42 (78%) were pure cultures and 9 (16.7%) were mixed, only 3 (5.6%) of the submitted samples had no growth. There were 42 pure isolates, the most common of which was Staphylococcus aureus 21 (50%), followed by Pseudomonas aeruginosa 14 (33.3%). Drug sensitivity pattern of Staphylococcus aureus showed that 61.9% were resistant to Penicillin while more than 90% were sensitive to Aminoglycosides and Clindamycin. Pseudomonas aeruginosa was resistant to penicillin in 64.3% of cases and Ciprofloxacin was active against pseudomonas in 85.7%.

Conclusion: The most common bacterial pathogens from CSOM include Staphylococcus aureus and Pseudomonas aeruginosa. Majority of the isolates of Staphylococcus aureus were resistant to penicillin. Aminoglycosides, macrolides and quinolones were effective against most of the isolates of Staphylococcus aureus.

Keywords: chronic otitis media, perforated tympanic membrane, chronic aural discharge