bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nødvendig, ikke ønskelig Utviklingen av ungdomsarbeidet i Lyngen-læstadianismen
Authors: Andreassen Bengt-Ove 
Published: August 2018

Ungdomsarbeid i religiøse bevegelser er i dag veletablert og lite kontroversielt. I enkelte læstadianske grupperinger er bildet noe mer sammensatt. Et eget ungdomsarbeid er et nokså nytt fenomen som læstadianerne har hatt et ambivalent forhold til. I 1999 ble et initiativ fra en lokal forsamling om mer organisert virksomhet for barn og ungdom blankt avvist av predikantene i Den luthersk-læstadianske menighet (også kalt Lyngen-retningen). I løpet av en tiårsperiode ble imidlertid bildet snudd, og ungdomsarbeidet er nå veletablert i denne læstadianske grupperingen. Artikkelen anlegger et historisk perspektiv for å vise hvordan et begrep og bevissthet om «ungdom» har vokst fram i etterkrigstiden, og danner bakgrunnen for forslaget som ble lansert i 1999. På bakgrunn av skriftlige kilder gjøres en analyse av hvordan ungdomsarbeidet nå har en selvfølgelig plass, og dermed er et eksempel på hvordan en bevissthet om «ungdom» og «ungdomsarbeid» kan sies å ha endret denne læstadianske forsamlingen. Nøkkelord:Læstadianisme, Lyngen-læstadianere, religion, ungdom, ungdomsarbeid Youth work in religious movements is today well established and uncontroversial. In some Laestadian groups (i.e. a Christian conservative revival tradition in Northern Scandinavia), the picture is somewhat more complex. Youth work in Laestadian groups is a relatively new phenomenon and still met with some ambivalence. This article will in a historical perspective show how a concept and awareness of "youth" has emerged in the postwar period within the Laestadian Lyngen-group. Using written sources, an analysis of how youth work now is valued, the article also raises the question whether youth and youth work have changed this Laestadian group.Keywords: The Laestadian movement, Laestadian, Lyngen group, religion, youth, youth work
Planarbeid i trosopplæring som ressurs for menigheten?
Authors: Birkedal Erling , Austnaberg Hans 
Published: August 2018

AbstractAll congregations in the Church of Norway have to make their own local plan for Christian education, according to a National curriculum. In this article we are following six congregations in their working process, and we are asking how the congregation can learn from the process for congregational planning in general. As theoretical perspectives we use Van Gelder’s technical and cultural changes and Senge’s five disciplines of learning organizations. We see that congregations can learn different attitudes and skills. The working process develops didactic insight and competence among staff and volunteers. Developing work about core activities in the congregation is not only a systematic, technical working process. It is especially a cultural endeavor, where you have to deal with different ideas, visions and values. Keywords: Christian education, Church of Norway, developing local plan, learning congregation SammendragAlle menigheter i Den norske kirke må utvikle sin egen lokale plan for trosopplæring. Artikkelen utforsker arbeidsprosessen med lokal plan i seks menigheter og undersøker sammenhengen mellom dette planarbeidet og utviklingsarbeid i menigheten generelt. Vi bruker Van Gelders skjelning mellom tekniske og kulturelle endringer, samt Senges fem disipliner for lærende organisasjoner som teoretiske perspektiv. Menighetene lærer ulike holdninger og ferdigheter gjennom planarbeidet. Det gir didaktisk innsikt og økt kompetanse hos ansatte og frivillige. Utvikling av en plan og gjennomføring av kjerneaktiviteter i menighetens trosopplæring er mer enn en systematisk, teknisk arbeidsprosess. Utviklingsarbeidet innebærer også kulturelle utfordringer, der en må bearbeide ulike ideer, visjoner og verdier. Nøkkelord: Trosopplæring, Den norske kirke, utvikling av lokal plan for trosopplæring, lærende menighet
Kritisk og upartisk? Utilsiktet religionskritikk i lærebøker for KRLE
Authors: Winje Geir 
Published: August 2018

I denne artikkelen undersøkes fem lærebøker i KRLE med tanke på om, og eventuelt hvordan, de formidler religionskritikk samtidig som de formidler religionskunnskap. Et hovedfunn er at lærebøkene eller utgiverne så å si aldri formulerer direkte kritikk av religionene, særlig ikke når det gjelder trosforestillinger. De kan imidlertid røpe en kritisk holdning til religionene i faget når det kommer til etikk og verdispørsmål, men i stedet for å formulere denne kritikken på en tydelig måte, antydes den – ofte ved å lede leserens oppmerksomhet i retning av det som er kritikkverdig. Jeg gir også eksempler på at lærebøkene kan omhandle problematiske forestillinger og praksiser uten å antyde dette for leserne. Til sist viser jeg hvordan KRLE-bøkene kan synes å kritisere religioner indirekte ved å tillegge dem en lav grad av relevans eller historisitet.Nøkkelord: lærebøker, krle, religionskritikk, religionerEnglish abstract This essay examines five textbooks written for ten years old pupils in the subject Religious Education in Norwegian school. The analysis is carried through to find out if, and eventually how, the books are criticizing the religions they describe. One central finding is that, even if the textbooks never criticize the beliefs of any of the main religions in the subject (i.e. Christianity, Judaism, Islam, Hinduism and Buddhism), they sometimes (but not always) bring discussable ethical practices or values to the reader’s attention. Besides, some religions (or some religious concepts) are presented as relevant for the readers, while others are not. The last finding accounted for is how some religious stories are presented as historical, while others are seen as myths or legends.Keywords: text books, religious education, religions, critizising religions
Ionic Modulation of the Interfacial Magnetism in a Bilayer System Comprising a Heavy Metal and a Magnetic Insulator for Voltage‐Tunable Spintronic Devices
Authors: Guan Mengmeng , Wang Lei , Zhao Shishun , Zhou Ziyao , Dong Guohua , Su Wei , Min Tai , Ma Jing , Hu Zhongqiang , Ren Wei , Ye Zuo‐Guang , Nan Ce‐Wen , Liu Ming 
Published: August 2018

AbstractThe voltage modulation of yttrium iron garnet (YIG) is of practical and theoretical significance; due to its advantages of compactness, high‐speed response, and energy efficiency, it can be used for various spintronic applications, including spin‐Hall, spin‐pumping, and spin‐Seebeck effects. In this study, a significant ferromagnetic resonance change is achieved within the YIG/Pt bilayer heterostructures uisng ionic modulation, which is accomplished by modifying the interfacial magnetism in the deposited “capping” platinum layer. With a small voltage bias of 4.5 V, a large ferromagnetic field shift of 690 Oe is achieved in heterostructures of YIG (13 nm)/Pt (3 nm)/(ionic liquid, IL)/(Au capacitor). The remarkable magnetoelectric (ME) tunability comes from the additional and voltage‐induced ferromagnetic ordering, caused by uncompensated d‐orbital electrons in the Pt metal layer. Confirmed by first‐principle calculations, this finding paves the way for novel voltage‐tunable YIG‐based spintronics.
Fused Carbazole‐Based Dyads: Synthesis, Solvatochromism and Sensing Properties
Authors: Zhang Simeng , Chen Weiben , Dai Gaole , Yang Fan , Chen Long 
Published: August 2018

AbstractA series of fused carbazole‐based luminophores with donor‐acceptor structures were synthesized (DCB‐H, DCB‐Br and TCB‐H). The photophysical, electrochemical properties, crystal packing structures were investigated in detail. The restriction of intermolecular rotation of benzophenone units lead to typical aggregation‐induced emission properties, giving potential to be used as fluorescence sensors for explosives, such as 2, 4, 6‐trinitrophenol.
In situ incorporation and loading of copper nanoparticles into a palmitic–lauric phase‐change material on polyester fibers
Authors: Rezaie A. B. , Montazer M. 
Published: August 2018

ABSTRACTThis article introduces a facile approach for applying a eutectic mixture of fatty acid phase‐change materials (PCMs) on polyester fibers for thermal conductivity improvement via the in situ incorporation of copper nanoparticles. For this purpose, a eutectic mixture of palmitic acid and lauric acid was applied as PCMs and ascorbic acid was applied for the synthesis of copper nanoparticles. The thermal properties and stability of the treated samples were also determined by differential scanning calorimetry and thermogravimetry analysis. The treated samples indicated appropriate phase‐transition temperatures between 29.1 and 36.8 °C, with relevant latent heats of 49.4 and 49.9 J/g, respectively. The in situ formation of copper nanoparticles into eutectic fatty acid applied on the polyester fibers resulted in the promotion of the thermal conductivity of the composite by about 100.1% with the maximum amount of nanoparticles. In addition, the treated samples maintained good thermal durability and stability after 100 melting and freezing cycles. In addition, the tensile strength of the treated samples was improved. Overall, this treatment could be used to produce promising form‐stabilized composite PCMs and thermoregulated polymers and textiles with appropriate phase‐transition ranges and thermal conductivity. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46951.
Bioluminescence and chemiluminescence abilities of trans‐3‐hydroxyhispidin on the luminous fungus Mycena chlorophos
Authors: Teranishi Katsunori 
Published: August 2018

AbstractThe fungus Mycena chlorophos emits green light from its pileus gills but not from its stipes. The chemical mechanisms underlying its bioluminescence are unclear. Trans‐3‐hydroxyhispidin has been known to be a luminescence substrate for the bioluminescent mycelia of Neonothopanus nambi and N. gardneri. In the present study, the bioluminescence and chemiluminescence abilities of trans‐3‐hydroxyhispidin on pileus gills and originally non‐bioluminescent stipes of M. chlorophos were demonstrated. Trans‐3‐hydroxyhispidin induced bioluminescence of living gills and stipes. The bioluminescence spectra of living gills and stipes measured after the addition of trans‐3‐hydroxyhispidin were consistent with the original bioluminescence spectrum of gills. Frozen–thawed (dead) gills and stipes maintained trans‐3‐hydroxyhispidin luminescence activity, and the luminescence‐active enzyme (luciferase) was partially purified in the water‐insoluble state from both tissues using gel filtration followed by ultracentrifugation. The optimum temperature of the chemiluminescence reactions of trans‐3‐hydroxyhispidin in the presence of partially purified gill or stipe luciferase was 25°C. The chemiluminescence quantum yields of trans‐3‐hydroxyhispidin for gill luciferase and stipe luciferase in 20 mM phosphate buffer at 25°C were 0.017 and 0.00096, respectively and the chemiluminescence spectra were almost consistent with the bioluminescence spectrum of living gills. These results indicate that trans‐3‐hydroxyhispidin can be a candidate as a substrate for M. chlorophos bioluminescence.
The regulatory role of APE1 in epithelial‐to‐mesenchymal transition and in determining EGFR‐TKI responsiveness in non‐small‐cell lung cancer
Authors: Yang Xiao , Peng Yu , Jiang Xuan , Lu Xianfeng , Duan Wei , Zhang Shiheng , Dai Nan , Shan Jinlu , Feng Yan , Li Xuemei , Cheng Yi , Yang Yuxin , Baugh Laura , Tell Gianluca , Wang Dong , Li Mengxia 
Published: August 2018

AbstractBackgroundEpithelial‐to‐mesenchymal transition (EMT) plays a pivotal role in resistance to EGFR tyrosine kinase inhibitors (TKIs) in non‐small‐cell lung cancer (NSCLC). Our previous study revealed that in osteosarcoma, human apurinic/apyrimidinic endonuclease 1 (APE1) regulates transforming growth factor‐β (TGF‐β), an important player in EMT. We therefore hypothesized a link between APE1 and EGFR‐TKI responsiveness in NSCLC.MethodsThe protein levels of APE1 were analyzed in tumors of NSCLC patients receiving EGFR‐TKI treatment. The correlation between APE1 expression and progression‐free survival (PFS), overall survival (OS), or response rate were analyzed. The impact of APE1 on the response to EGFR‐TKIs was measured by exogenous manipulation of APE1 in EGFR‐TKI‐sensitive and EGFR‐TKI‐resistant cells.ResultsWe indicate that low expression of APE1 in tumors is associated with a significantly longer PFS (20.8 months vs 8.4 months, P = 0.008) and a preferential OS (39.0 months vs 17.0 months, P = 0.001), with no difference in initial response rate to EGFR‐TKIs. We observed that APE1 protein level was significantly increased in EGFR‐TKI‐resistant cells and was associated with downregulated E‐cadherin and upregulated vimentin. The EMT phenotype, as well as the levels of TGF‐β, was suppressed in APE1 knockdown HCC827/IR and PC‐9/ER cells, while the EMT phenotype was promoted in APE1‐overexpressed HCC827 and PC‐9 cells. Furthermore, a specific APE1 redox inhibitor (ie, E3330) effectively reversed the EMT phenotype and further sensitized the cells to EGFR‐TKIs.ConclusionThis study revealed a significant role of APE1 in EGFR‐TKI resistance via novel regulatory effects on the EMT phenotype in NSCLC.
Characterization and drug sensitivity of a novel human ovarian clear cell carcinoma cell line genomically and phenotypically similar to the original tumor
Authors: Franklin Miriam , Gentles Lucy , Matheson Elizabeth , Bown Nick , Cross Paul , Ralte Angela , Gilkes‐Immeson Connor , Bradbury Alice , Zanjirband Maryam , Lunec John , Drew Yvette , O'Donnell Rachel , Curtin Nicola J. 
Published: August 2018

AbstractNUCOLL43 is a novel ovarian clear cell carcinoma (O‐CCC) cell line that arose from a primary culture of a patient's malignant ascites. The cells grow reliably in cell culture with a doubling time of approx. 45 hours and form colonies at high efficiency. They have a very high degree of loss of heterozygosity (LOH) affecting approximately 85% of the genome, mostly copy neutral and almost identical to the original tumor. The cells express epithelial (pan‐cytokeratin) and mesenchymal (vimentin) characteristics, CA125 and p16, like the original tumor. They also express ARID1A but not HNF‐1β and, like the original tumor, and are negative for p53 expression, with no evidence of p53 function. NUCOLL43 cells express all other DNA damage response proteins investigated and have functional homologous recombination DNA repair. They are insensitive to cisplatin, the PARP inhibitor rucaparib, and MDM2 inhibitors but are sensitive to camptothecin, paclitaxel, and NVP‐BEZ235. The NUCOLL43 cell line represents a distinct subtype of O‐CCC that is p53 and HNF‐1β null but expresses ARID1A. Its high degree of similarity with the original tumor genomically and proteomically, as well as the high level of LOH, make this an interesting cell line for O‐CCC research. It has been deposited with Ximbio.
Efficacy of icotinib in advanced lung squamous cell carcinoma
Authors: Liang Shuai , Xu Yan , Tan Fenlai , Ding Lieming , Ma Yongbin , Wang Mengzhao 
Published: August 2018

AbstractBackgroundThere are controversial data supporting the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with advanced lung squamous cell carcinoma (SCC). In this study, the efficacy of icotinib in unselected and EGFR‐mutated patients with lung SCC was assessed.MethodsWe retrospectively analyzed the survival time of unselected advanced lung SCC patients treated with icotinib for at least 5 months between June 2013 and June 2016, and selected appropriate EGFR‐mutated advanced lung ADC patients to have 1:1 ratio of propensity score matching with EGFR‐mutated advanced lung SCC patients, and matching factors were age, sex, clinical stage, Karnofsky performance status (KPS), smoking history, EGFR mutation type, and treatment lines.ResultsA total of 487 unselected advanced lung SCC patients were available for analysis of icotinib treatment efficacy. The progression‐free survival (PFS) was 13.0 months (95% CI 12.2‐13.8), the overall survival (OS) was 16.0 months (95% CI 14.7‐17.3), and the objective response rate (ORR) was 41.3%. After propensity score matching, 78 EGFR‐mutated lung SCC and 78 EGFR‐mutated lung ADC patients were selected and compared. Although no statistical difference was found, ADC patients were associated with a longer PFS (15.8 months vs 12.7 months, P = 0.275) and OS (24.2 months vs 18.5 months, P = 0.150), and a better ORR (59.0% vs 48.7%, P = 0.199) than compared with SCC patients when treated with icotinib.ConclusionIcotinib has a modest therapeutic effect in patients with advanced lung SCC, especially for the population with EGFR mutations.
LiTaO3 Single Crystal Growth by the Vertical Bridgman Technique
Authors: Nishimura Eiichiro , Okano Katsuhiko , Iida Junji , Hoshikawa Keigo 
Published: August 2018

AbstractLithium tantalate, LiTaO3 (LT), single crystal growth by the vertical Bridgman (VB) technique is attempt for the first time. In the present VB‐LT technique, pure platinum crucibles are used in a furnace with a graphite heater and an argon atmosphere. One‐hundred percent solidified crack‐free VB‐LT crystals are successfully grown by composing the initial melts with exactly congruent compositions. The fundamental technical issues for VB‐LT growth are also clarified.
Erythropoietic effects of low‐dose cobalt application
Authors: Hoffmeister Torben , Schwenke Dirk , Wachsmuth Nadine , Krug Oliver , Thevis Mario , Byrnes William C. , Schmidt Walter F.J. 
Published: August 2018

AbstractCobaltous ions (Co2+) stabilize HIFα, increase endogenous erythropoietin (EPO) production, and may, therefore, be used as a performance‐enhancing substance. To date, the dosage necessary to stimulate erythropoiesis is unknown. The aim of this study was, therefore, to determine the minimum dosage necessary to increase erythropoietic processes. In a first double‐blind placebo‐controlled study (n = 5), single oral Co2+ dosages of 5 mg (n = 6) and 10 mg (n = 7) were administered to healthy young men. Cubital venous blood and urine samples were collected before and up to 24 hours after Co2+ administration. In a second study, the same daily Co2+ dosages were administered for five days (placebo: n = 5, 5 mg: n = 9, 10 mg: n = 7). Blood and urine samples were taken the day before administration and at day 3 and day 5. Plasma [EPO] was elevated by 20.5 ± 16.9% at 5 hours after the single 5‐mg administration (p < 0.05) and by 52.8 ± 23.5% up to 7 hours following the 10‐mg Co2+ administration (p < 0.001). Urine [Co2+] transiently increased, with maximum values 3–5 hours after Co2+ ingestion (5 mg: from 0.8 ± 1.1 to 153.6 ± 109.4 ng/mL, 10 mg: from 1.3 ± 1.7 to 338.0 ± 231,5 ng/mL). During the five days of Co2+ application, 5 mg showed a strong tendency to increase [EPO], while the 10‐mg application significantly increased [EPO] at day 5 by 27.2 ± 26.4% (p < 0.05) and the immature reticulocyte fraction by 49.9 ± 21.7% (p < 0.01). [Ferritin] was decreased by 12.4 ± 10.4 ng/mL (p < 0.05). An oral Co2+ dosage of 10 mg/day exerts clear erythropoietic effects, and 5 mg/day tended to increase plasma EPO concentration.
Detection of the designer benzodiazepine flunitrazolam in urine and preliminary data on its metabolism
Authors: Ameline Alice , Richeval Camille , Gaulier Jean‐Michel , Raul Jean‐Sébastien , Kintz Pascal 
Published: August 2018

AbstractDesigner benzodiazepines have emerged as recreational drugs. They are available via the Internet without control and are found in the form of falsified (fake) medicines. For some of them, limited information concerning their effects, their toxicity, and their detection in bio fluids is available in the literature. For others, nothing has been published, as in the case of flunitrazolam (FNTZ). To gain preliminary data on its elimination parameters in urine and to investigate its metabolism, one of the authors ingested one pink tablet bought on the Internet, after confirming the absence of other compounds and agreement with the labeled dosage (0.25 mg) by nuclear magnetic resonance (NMR). A software algorithm (MetaboLynx, Waters, Milford, MA, USA) was used to predict FNTZ biotransformation and four potential metabolites were proposed: 4‐hydroxy‐FNTZ, desnitro‐FNTZ, 7‐amino‐FNTZ, and 7‐acetamido‐FNTZ. Urine samples were collected over 72 hours following oral administration of one tablet. After liquid/liquid extraction at pH 9.5, FNTZ concentrations were determined using ultra performance liquid chromatography–triple quadrupole–mass spectrometry (UPLC–QqQ–MS/MS). FNTZ remained detectable in hydrolyzed urine for 21 hours after ingestion, with concentrations ranging between 1 and 18 ng/mL. About 3% of the initial dose was excreted in urine as total unchanged FNTZ during this period. In vitro experiments (HLM incubations) were performed using ultra performance liquid chromatography–quadrupole time of flight‐mass spectrometry (UPLC–QTOF–MS) in order to investigate the potential CYP‐ and UGT‐dependent metabolites where only 7‐amino‐FNTZ was detected as the only metabolite. However, in the urine specimens, desnitro‐FNTZ, 7‐acetamido‐FNTZ and 7‐amino‐FNTZ were the main detected compounds. The identification of FNTZ metabolites dramatically improves the detection windows of the drug up to 37 hours.
Thermoeconomic analysis and multiobjective optimization of a combined gas turbine, steam, and organic Rankine cycle
Authors: Mohammadi Amin , Ashouri Milad , Ahmadi Mohammad Hossein , Bidi Mokhtar , Sadeghzadeh Milad , Ming Tingzhen 
Published: August 2018

AbstractBecause of the fossil fuels crisis in recent years, efficient working of power producing cycles has gained considerable importance. This study presents a detailed exergoeconomic analysis of a proposed combination of a gas turbine (GT), a steam Rankine cycle (SRC), and an organic Rankine cycle (ORC), which are coupled together to obtain the maximum heat recovery of the GT exhaust gas. The proposed cycle was analyzed from both thermodynamic and economic viewpoints. The exergy efficiency and product cost rate of the introduced cycle were optimized simultaneously using multiobjective optimization with seven decision variables, including steam turbine inlet pressure and temperature, ORC turbine inlet pressure, ORC and steam turbine back pressures, and pinch point of heat exchangers. Sensitivity analysis revealed that the steam turbine back pressure and inlet pressure had the highest impact on product cost rate and exergy efficiency, followed by ORC turbine inlet pressure and back pressure. Also, the exergoeconomic analysis showed that the combustion chamber had the highest sum of exergy destruction costs and investment costs; more attention should thus be paid to its design procedure. Under the design conditions, the exergy efficiency of 40.75% and product cost rate of 439 million $/year could be achieved.