bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pilot clinical study of adjunctive therapy with selective intracoronary hypothermia in patients with ST‐segment elevation myocardial infarction
Authors: Wang Yong‐Sheng , Zhang Jian , Li Ya‐Fei , Chen Bing‐Rui , Khurwolah Mohammad Reeaze , Tian Yun‐Fan , Shi Hao‐Jie , Yang Zhi‐Jian , Wang Lian‐Sheng 
Published: September 2018

AbstractObjectivesWe aimed to assess the effect of selective intracoronary hypothermia on outcomes in patients with ST‐segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).BackgroundIntracoronary hypothermia, the feasibility and safety of which has been validated in humans, induced by selective trans‐coronary infusion of saline at different temperatures can reduce infarct size (IS) prior to reperfusion in animal models of STEMI.MethodsSixty STEMI patients presenting with thrombolysis in myocardial infarction (TIMI) flow grade 0/1 were randomized after coronary artery angiography. Intracoronary hypothermia was induced by selective trans‐coronary infusion of saline at 4°C to the endangered myocardium in the 30 patients. The primary endpoint, absolute IS expressed as IS/myocardium at risk (MaR), was assessed by cardiac magnetic resonance imaging at day 7 post‐PPCI in 50 patients. Clinical follow‐up was undertaken at day 30 after procedure.ResultsIntracoronary hypothermia was successfully performed in hypothermia group, without increase in arrhythmia or hemodynamic instability. The mean temperature reduction of 5.8 ± 1.1°C in distal coronary artery was achieved before reperfusion. Mean IS/MaR was predominantly reduced in the hypothermia group (44.85 ± 5.89% vs. 50.69 ± 10.75%, P = 0.022), especially in the anterior STEMI subgroup (46.12 ± 7.54% vs. 55.27 ± 11.175%, P = 0.023). The clinical events appeared no statistical difference between the two groups at the 30‐day follow‐up.ConclusionThe statistical difference in IS/MaR by intracoronary hypothermia as adjunctive therapy to PPCI is an important observation and warrants a larger pivotal trial fully powered for efficacy.
Comparison of 3‐year clinical outcomes after endovascular therapy for aortoiliac artery occlusive disease between patients with and without hemodialysis: Subanalysis of the REAL‐AI registry
Authors: Tokuda Takahiro , Hirano Keisuke , Soga Yoshimitsu , Iida Osamu , Kawasaki Daizo , Yamauchi Yasutaka , Suzuki Kenji , Kamoi Daisuke , Tazaki Junichi 
Published: September 2018

AbstractPurposeThe impact of hemodialysis (HD) on aortoiliac (AI) occlusive lesions remains unknown. Here, we report the 3‐year clinical outcomes of endovascular treatment (EVT) for AI occlusive lesions in propensity‐matched populations of patients who did and did not undergo HD.MethodsThe cohort of this large‐scale, multicenter, retrospective registry study included 574 consecutive patients with AI occlusive disease. Propensity score‐matched analysis was performed to compare AI occlusive lesions between patients who did and did not undergo HD. The endpoints were primary patency, assisted primary patency, and secondary patency as well as overall survival and major adverse limb events (MALEs).ResultsA total of 57 matched pairs of patients who did and did not undergo HD were analyzed after propensity score‐matched analysis. No significant difference was observed in primary patency, assisted primary patency, secondary patency, and MALEs at 3 years. The survival rate was significantly lower in the HD group than in the without‐HD group (68% vs. 93%, P = 0.03).ConclusionsAlthough the survival rate of HD patients was poor, the results of EVT for AI occlusive lesions were reasonable in these patients.
Early restenosis of resorbable magnesium scaffolds: Optical coherence tomography findings
Authors: García‐Guimaraes Marcos , Antuña Paula , Cuesta Javier , Alfonso Fernando 
Published: September 2018

AbstractResorbable Magnesium Scaffolds (RMS) represent an interesting alternative to current drug‐eluting stents. Current data from clinical trials seems to confirm good performance of these new devices with low rates of late device failure. Little is known about mechanisms leading to RMS failure. Herein, we present the first description of an early RMS in‐scaffold restenosis. Optical coherence tomography (OCT) analysis at implantation detected acute non‐severe malapposition and underexpansion as main promoters of RMS failure. OCT during in‐scaffold restenosis intervention confirmed early severe neointimal proliferation and RMS late recoil and dismantling as the main mechanisms of device failure. We hypothesize that the fast resorption process of RMS may lead to an early loss of radial strength, that could favor late recoil, acquired underexpansion, device dismantling and might interact with distribution of sirolimus. This case also illustrates that OCT is pivotal to unravel both acute and acquired mechanisms related to RMS failure.
Percutaneous melody valve implantation in a native tricuspid valve following failed surgical repair
Authors: Sumski Christopher A. , Bartz Peter , Gudausky Todd 
Published: September 2018

AbstractTranscatheter valve‐in‐valve and valve‐in‐ring implantation has become a common approach to treating patients with failed bioprosthetic tricuspid valves as well as failed surgical repairs of the tricuspid valve where an annuloplasty ring has been utilized. We describe a case where a Melody valve was percutaneously implanted in a native tricuspid valve with severe stenosis following surgical repair without a supporting annuloplasty ring.
Buddy‐wire technique during rotational Atherectomy: Simple and effective solution to achieve strong back‐up support
Authors: Mitomo Satoru , Demir Ozan M. , Latib Azeem , Colombo Antonio 
Published: September 2018

AbstractA 52‐year‐old male underwent percutaneous coronary intervention (PCI) using rotational atherectomy (RA: 1.5‐mm burr) for a severely calcified lesion in the proximal to mid obtuse marginal (OM) branch. Even with 7 Fr extra back‐up guiding catheter via femoral access, the burr could not cross the lesion due to insufficient back‐up support. In order to achieve stronger back‐up support, we kept the burr at the position in the OM branch and placed a supportive wire in left anterior descending artery through the side of drive‐shaft sheath of the Rotablator, which sufficiently stabilized the guiding catheter during the ablation and the burr crossed the lesion. This case demonstrates that a simple technique of placing additional supportive wire in the other vessel during RA could be an effective and safe solution to facilitate improved back‐up support without necessity to change the PCI system used already.
Simultaneous transfemoral transcatheter aortic valve replacement and trans‐septal mitral valve‐in‐ring implantation after partial laceration of an Alfieri stitch
Authors: Garcia Santiago , Mbai Mackenzie , Kelly Rosemary , Bertog Stefan 
Published: September 2018

AbstractIn patients with an Alfieri Stitch transcatheter mitral valve replacement (TMVR) may be difficult due to the double orifice configuration of the mitral valve. We report a case of simultaneous and completely percutaneous TAVR and TMVR using LAMPOON‐related techniques prior to TMVR to allow for optimal valve deployment.
Impact of diabetes on clinical outcomes after revascularization with sirolimus‐eluting and biolimus‐eluting stents with biodegradable polymer from the SORT OUT VII trial
Authors: Ellert Julia , Christiansen Evald Høj , Maeng Michael , Raungaard Bent , Jensen Svend Eggert , Kristensen Steen Dalby , Veien Karsten Tange , Junker Anders Bo , Jakobsen Lars , Aarøe Jens , Terkelsen Christian Juhl , Kahlert Johnny , Villadsen Anton Boel , Bøtker Hans Erik , Jensen Lisette Okkels 
Published: September 2018

AbstractObjectivesIn this substudy of the SORT OUT VII trial, the clinical outcomes among patient with diabetes mellitus treated with Orsiro sirolimus‐eluting stent (O‐SES; Biotronik, Bülach, Switzerland) or Nobori biolimus‐eluting stent (N‐BES; Terumo, Tokyo, Japan) were compared.BackgroundDiabetes is associated with increased risk of target lesion failure (TLF) after percutaneous coronary intervention.MethodsIn total, 2525 patients were randomized to stent implantation with O‐SES (n = 1261, diabetes: n = 236) or N‐BES (n = 1264, diabetes: n = 235). The primary endpoint, TLF, was a composite of cardiac death, target‐lesion myocardial infarction (MI), or target lesion revascularization (TLR) within 2 years.ResultsAt 2 year, TLF did not differ between O‐SES vs N‐BES in diabetic (9.3% vs 9.4%; RR 0.98, 95% CI 0.54–1.78) patients. The individual components of the primary endpoint did not differ among stent type. In diabetics, cardiac death occurred in 3% of O‐SES‐treated and in 3.8% of N‐BES‐treated patients (RR 0.77, 95% CI 0.29–2.08), MI occurred in 3.0% of O‐SES‐treated and in 3.8% of N‐BES‐treated patients (RR 0.76, 95% CI 0.28–2.06) and TLR occurred in 5,5% of O‐SES‐treated and in 6.0% of N‐BES‐treated patients (RR 0.91, 95% CI 0.43–1.95).ConclusionTLF did not differ between O‐SES‐ and N‐BES‐treated diabetic patients.
Outcome of staged percutaneous coronary intervention within two weeks from admission in patients with ST‐segment elevation myocardial infarction with multivessel disease
Authors: Fukutomi Motoki , Toriumi Shinichi , Ogoyama Yukako , Oba Yusuke , Takahashi Masao , Funayama Hiroshi , Kario Kazuomi 
Published: September 2018

AbstractBackgroundThe optimum timing of revascularization strategy for stenoses in nonculprit vessels in patients with ST‐segment elevation myocardial infarction (STEMI) and multivessel disease (MVD) remains unclear. At present, there is no evidence investigating the outcome of staged percutaneous coronary intervention (PCI) within two weeks from admission among STEMI patients with MVD.MethodsA total of 210 STEMI patients with MVD who underwent primary PCI were analyzed. We compared the all‐cause mortality and major adverse cardiovascular events (MACE) (cardiovascular death, myocardial infarction, heart failure, unstable angina, and stroke) with median follow‐up of 1200 days among the patients who underwent staged PCI within two weeks from admission (staged PCI ≤2 W) (n = 75), staged PCI after two weeks from admission (staged PCI >2 W) (n = 37) and culprit‐only PCI (n = 98) in patients with STEMI and MVD.ResultsThe staged PCI ≤2 W showed lower all‐cause mortality than culprit‐only PCI (4.0 vs 29.6%, log‐rank P = 0.001), and lower incidence of MACE than the staged PCI >2 W group (1.3 vs 18.9%, log‐rank P = 0.001) and culprit‐only PCI group (1.3 vs 22.5%, log‐rank P = 0.001). In the multivariable Cox regression analysis, the staged PCI ≤2 W was a predictor of lower all‐cause mortality (hazard ratio [HR], 0.176; 95% confidence interval [CI], 0.049‐0.630; P = 0.008) and lower incidence of MACE (HR, 0.068; 95% CI, 0.009‐0.533; P = 0.011), but staged PCI >2 W was not.ConclusionIn conclusion, staged PCI within two weeks after admission showed more favorable outcomes compared with staged PCI after two weeks from admission or culprit‐only PCI in STEMI patients with MVD.
Radial vs femoral access for the prevention of acute kidney injury (AKI) after coronary angiography or intervention: A systematic review and meta‐analysis
Authors: Andò Giuseppe , Gragnano Felice , Calabrò Paolo , Valgimigli Marco 
Published: September 2018

AbstractObjectivesWe sought to investigate the impact of radial vs femoral access on the incidence of acute kidney injury (AKI) after coronary angiography or intervention.BackgroundThere is a growing recognition of the importance of access site selection as an adjudicative measure to mitigate the risk of renal impairment for patients with coronary artery disease undergoing angiography with or without percutaneous coronary intervention.MethodsWe conducted a systematic review of the literature and meta‐analyzed available evidence comparing the rates of AKI with radial vs femoral access in patients undergoing coronary angiography or intervention. Studies reporting the incidence of AKI as a primary or secondary outcome were pooled in fixed‐ and random‐effects meta‐analyses and meta‐regression techniques were used to account for across‐study heterogeneity.ResultsAcross data pooled from nine studies (n = 32 181), radial access was significantly associated with a reduction in the incidence of AKI (OR 0.57, 95% CI 0.50 to 0.66, P < 0.0001 with fixed‐effects model, OR 0.55, 95% CI 0.45 to 0.67, P < 0.0001 with random‐effects model) as compared to femoral. In the meta‐regression model, the effect size of radial access effect was related to the number of centers in which studies were conducted.ConclusionsCompared with the femoral approach, radial access was associated with a lower incidence of AKI after coronary angiography or intervention, although this benefit was less pronounced in multicenter than in single‐center studies.
A hybrid technique for treatment of commissural primary mitral regurgitation
Authors: Raphael Claire E , Malouf Joseph F , Maor Elad , Panaich Sidakpal S , Pollak Peter M , Reeder Guy S , Rihal Charanjit S , Eleid Mackram F 
Published: September 2018

AbstractBackgroundMitraClip is an effective transcatheter therapy for mitral regurgitation (MR). However, MitraClip is challenging in commissural MR and the optimal therapeutic approach is unclear.MethodsWe describe a case series of six consecutive patients with severe commissural primary mitral regurgitation who underwent MitraClip insertion followed by an Amplatzer Vascular Plug (AVP) II occluder between the commissure and the MitraClip.ResultsThe procedure was successful in all patients. MR was reduced from severe to mild/trivial in 50% and moderate in 50% of cases. On 30‐day follow‐up, NYHA class had improved from III (6 patients) to I (2 patients), II (2 patients), and III (2 patients). The mean transmitral gradient was 2.5 ± 1.8 mmHg at baseline and 4.8 ± 2.6 mmHg following the procedure. One patient developed hemolysis immediately post procedure. The other five patients remained well during a median follow‐up of 20 months (range 5–50 months) with no reported device dislodgement.ConclusionsElective treatment of severe commissural MR with a laterally or medially placed MitraClip coupled with an AVP II occluder between the clip and the commissure is feasible and safe. This approach may provide a useful management alternative in selected patients.
Thrombocytopenia after transcatheter aortic valve implantation. A comparison between balloon‐expandable and self‐expanding valves
Authors: Hernández‐Enríquez Marco , Regueiro Ander , Romaguera Rafael , Andrea Rut , Gómez‐Hospital Joan Antoni , Pujol‐López Margarida , Ferreiro‐Gutiérrez José Luis , Brugaletta Salvatore , Roura Gerard , Freixa Xavier , Gómez‐Lara Josep , Martín‐Yuste Victoria , Gracida Montserrat , Cequier Ángel , Sabaté Manel 
Published: September 2018

BackgroundThrombocytopenia after transcatheter aortic valve implantation (TAVI) is common and has been related to higher mortality and major complications. No comparison between balloon‐expandable (BEV) and self‐expanding valves (SEV) regarding drop platelet count (DPC) has been reported to date. The objectives of this study were to analyze the differences in DPC between BEVs or SEVs and their prognostic implications in clinical outcomes.MethodsWe retrospectively analyzed patients undergoing TAVI. Platelet counts after TAVI were collected. Two groups were created: DPC ≤ 30% and DPC > 30%. VARC‐2 criteria were used to define outcomes.ResultsStudy population was composed of 195 patients (age 77.5 ± 6.7, 57.4% males). All of them but one experienced DPC (mean DPC 31.9 ± 15.3%). DPC was significantly higher among the patients treated with BEV compared to those treated with SEV (36.3 ± 15.1% vs 27.7 ± 14.4, P < 0.001). After multivariate analysis, the use of BEV was independently associated with a higher rate of DPC > 30% (67.4% vs 36.0%; OR 3.4; 95% CI, 1.42‐8.16). At 30 days, the DPC > 30% was associated with a higher rate of life‐threatening/major bleeding, major vascular complications, in‐hospital sepsis and mortality. At one year, there were no statistically significant differences in the mortality rate between groups (6.35% vs 10.0%, HR 1.54; 95% CI, 0.56–4.25).ConclusionsIn this study, the use of BEV was associated with a higher risk of DPC after TAVI. A DPC rate > 30% was associated with an increased risk of major complications at 30 days.
Bioelectronics and Interfaces Using Monolayer Graphene
Authors: Macedo Lucyano J. A. , Iost Rodrigo M. , Hassan Ayaz , Balasubramanian Kannan , Crespilho Frank N. 
Published: September 2018

AbstractGraphene is expected to revolutionize several application areas ranging from portable energy conversion and storage to miniaturized biosensors for medical applications. In this endeavor, the control of surface characteristics is an essential aspect for understanding fundamental phenomena occurring at the graphene‐liquid interface. In this comprehensive review, we address recent progress in the investigation of the interfacial characteristics of monolayer graphene and methods for modulating the physical and chemical properties of this interface. We focus on the electrochemistry and field‐effect measurements in liquid, which provide an improved understanding of the unique graphene‐liquid interface, with due consideration of the influence of the underlying substrate and structural defects in graphene. Finally, we present reported examples of using single graphene monolayers in miniaturized devices for realizing sensors, neural interfaces and batteries.
Mesopore Engineering for Well‐Defined Mesoporosity in Al‐Rich Aluminosilicate Zeolites
Authors: Zhang Dazhi , Jin Changzi , Zou Mingming , Huang Shengjun 
Published: September 2018

AbstractDesilication has been proven an effective approach for the construction of well‐defined hierarchical porosities inside zeolites with an optimal framework Al content (Si/Al=25–50). However, for the Al‐rich aluminosilicate zeolites, desilication is constrained by the excess and extensive shielding effects from high Al‐contents. The developments in the desilication of siliceous zeolites convey a simplified principle of controlled dissolution of the microporous matrix for the construction of hierarchical porosities, which benefits the innovation of synthetic approaches for Al‐rich zeolites. The perturbations to the environments of framework Al species may alleviate the excess shielding effects. This review highlights two corresponding protocols of sequential “fluorination–desilication” and “steaming–desilication” for the construction of hierarchical porosities inside Al‐rich ZSM‐5 zeolites. The success of these two protocols revitalizes the prevailing understanding of the interplay between dealumination and desilication, and implies the necessity of investigating the overlooked roles of extra‐framework Al species. Despite the long history and significant achievements in the last decade, fundamental understandings at the molecule level are still limited for the desilication‐based top‐down approaches. In particular, the investigations on Al‐rich zeolites just find their growing. The bridging of dealumination and desilication is essential for other industrially relevant Al‐rich zeolites (e.g., faujasite zeolites). The complexities in the inherent characters (topology, spatial distribution, proximity, etc.) and apparent parameters (morphology, crystal/particle size, etc.) demand constructive synthetic toolboxes and further fundamental understanding.
Photoreduction of Thioether Gold(III) Complexes: Mechanistic Insight and Homogeneous Catalysis
Authors: Cao Zhen , Bassani Dario M. , Bibal Brigitte 
Published: September 2018

AbstractComplexes formed between AuCl3 and thioether ligands underwent a photoinduced reductive elimination under homogeneous conditions in dichloromethane and toluene solutions to afford the corresponding AuI complexes. All the gold(III) complexes were rapidly reduced to the gold(I) chloride complexes under 365 nm irradiation or ambient light while being thermally stable below 55 °C. The mechanism of photoreduction through Cl2 elimination is discussed based on a kinetic study and the chemical trapping of chlorine species: Cl2, radical Cl., and possibly Cl+. The catalytic activities of the gold(III) chloride complexes and the corresponding gold(I) complexes obtained by in situ reduction were evaluated in the cyclization of N‐propargylic amides to oxazoles. The merits of such photoreducible complexes in homogeneous gold catalysis are illustrated by a cascade reaction catalyzed by thioether gold complexes that affords a 4H‐quinolizin‐4‐one in high yields.
Characteristic and discrimination of unconventional oil samples by two‐dimensional extraction combined with concentration‐resolved fluorescence spectroscopy
Authors: Wang Chunyan , Huang Xiaodong , Fan Xinmin , He Weidong , Zhang Lujun 
Published: September 2018

AbstractFluorescence detection of petroleum related samples has excellent application value for unconventional oil exploration and petrochemical detection. In this paper, based on the concentration‐resolved fluorescence spectra, the synchronous fluorescence spectra were used in the range of 3.0 × 10−3 g/L to 5.0 g/L for different kinds of petroleum samples and petrochemical products with n‐hexane and isopropanol as extractants. A red shift of the fluorescence spectra with an increase in the concentration was found under both extractants. The solubility of n‐hexane on crude oil was stronger while that of isopropanol was better for aromatic compounds. The results show that the effect of different extracting agents on the spectra can be used to acquire more information about aromatics components in petroleum related samples, which should be carefully considered in the process of quantitative and qualitative analysis of crude oil samples by fluorescence spectra. It is also shown that the combined extraction of different extractants could enhance the analytical ability of the fluorescence spectrometry, and the rapid, non‐contact measurement is promising for in‐field use.
Geometric skew image classification algorithm based on fusion adaptive reasoning
Authors: Liu Zhengyu , Chang Zhiqiang 
Published: September 2018

SummaryThe geometric skew model is widely used in image classification and image retrieval. In the traditional skew model, the geometric topology statistical method ignores the spatial information between geometric words and the classification object shape information, which leads to the distinguishing ability of image features. In this paper, we propose a geometric skew method with adaptive reasoning. Combined with significant region extraction and geometric topology, we not only can generate more representative geometric topologies but also can avoid complex background information and position change bands to a certain extent. First, the adaptive reasoning geometric skewness model is constructed on the obtained significant area by carrying out the significant region extraction of the training image. Second, in order to describe the characteristics of the image more accurately, it can resist the changing position and background information. The method uses the geometric topology strategy and the polygon segmentation method to integrate global information and local information. Through the simulation experiment and compared with the traditional skewness model and other models, the results show that the method proposed in this paper obtains higher intelligence image classification accuracy.