bluuebunny/crossref_metadata_2025_split huggingface dataset:
The application of povidone in the preparation of modified release tablets
Authors: Kasperek Regina , Zimmer Lukasz , Zun Maria , Dwornicka Dorota , Wojciechowska Katarzyna , Poleszak Ewa 
Published: March 2018

Abstract
The aim of the study was to investigate the modified release of a model substance, of tablets containing different types of Kollidon and particular additives. Additionally, the release kinetics and mechanism of prolonged release of certain tablet preparations were investigated. In this work, tablets containing different types of povidone (Kollidon CL, Kollidon 30, Kollidon SR and other excipients) were prepared by the direct compression technique. The results showed that tablets with fast disintegration and release should contain in their composition, Kollidon CL, lactose and Avicel, however, the use of β-CD instead of lactose or Avicel brings about a slight prolongation in the disintegration time of tablets and the release of an active substance. Furthermore, while other tablet compositions generated within this study must be considered as being prolonged release types, only two of these showed the best fitted mathematical models. The in vitro dissolution data reveal that the dissolution profiles of the two formulations, one containing Kollidon SR with the addition of Kollidon 30, and the second with HPMC K15M, Kollidon 30, Kollidon CL and lactose, best fitted the Higuchi model. Moreover, the release mechanism of these two formulations plotted well into Korsmeyer-Peppas, indicating a coupling of drug diffusion in the hydrated matrix, as well as polymer relaxation – the so-called anomalous transport (non-Fickian).
The history of pharmacy in Adamów
Authors: Wrobel Andrzej , Korzeniowska Malgorzata , Polak Agnieszka , Szczygiel Marcin , Wrobel Rafal 
Published: March 2018

Abstract
This is one of a series of articles about pharmacists in Lublin district, in the 19th and 20th c. The first recorded owner of the pharmacy in Adamów was Aleksander Biernacki (1851-1897), who passed it onto his son-in-law, Aleksander Rogoziński (1873-1941), and who, in turn, passed it onto his son, Stanisław Rogoziński (1913-1998), married to Tatiana (1918-1998). This family's history is an example of the history of Polish intelligentsia in the second half of 19th c., in the times of the Russian partition, World War I, 1918-1939, World War II and until contemporary times.
Sonographic parameters of the pancreas and gall bladder in healthy men from Podillya region of Ukraine of different somatotypes
Authors: Gunas Igor , Prokopenko Sergiy , Melnik Marina 
Published: March 2018

Abstract
In this work, we undertook a study of the sonographic parameters of the pancreas and gall bladder in healthy men with different somatotypes. The study-subjects were from the Podillya region of Ukraine. Herein, the majority of gallbladder dimensions (length, thickness, cross-sectional area and volume) in men type-classified as endo-mesomorphic, were significantly higher when compared with men in general and with those of the meso- and ecto-mesomorphic somatotype. Furthermore, the dimensions of the pancreas (width of head and tail length) in mesomorphic males were significantly higher than that of endo-mesomorphic males. The rest of the studied parameters (length, longitudinal cross section area of the gall bladder, the thickness of the head, body and head length, the width of the body and tail of the pancreas) in men of the different somatotypes have no significant differences.
Features of somatotype and body weight component composition in patients with acne: boys and girls of Podillya region of Ukraine
Authors: Gunas Igor , Majewski Olexandr , Makarchuk Irina 
Published: March 2018

Abstract
The article describes the differences in peculiarities of somatotype and body weight component composition in patients with acne, the study population being boys and girls of the Podillya region of Ukraine. In the study subjects, regardless of sex, body muscle mass, bone mass and the mesomorphic somatotype component of those with acne were significantly greater, while fat body mass indicators and the endomorphic somatotype component was smaller – in comparison to that of non-afflicted subjects of similar gender. Regarding the ectomorphic component of somatotype, between the surveyed groups of those with and without acne, whether male or female, no significant differences were revealed. For all indicators, whether the somatotype components or the component composition of body weight, between groups of boys or girls with different degrees of severity of acne, again no significant differences were established.
Glycyrrhetinic acid and its derivatives in infectious diseases
Authors: Langer Dominik , Czarczynska-Goslinska Beata , Goslinski Tomasz 
Published: March 2018

AbstractIntroduction.Licorice or liquorice (Glycyrrhiza glabra, Leguminosae) is a perennial plant naturally occurring or cultivated in Europe and Asia. It was appreciated by many ancient cultures, and was employed within Arabic medicine and (beginning in the Middle Ages) in Europe folk medicine as a remedy for many diseases. Currently, the sweet flavoured root of this plant – Radix Glycyrrhizae (Liquirtiae), is widely taken for the treating of various upper respiratory tract diseases, as well as for gastric ulcer disease. It is also utilized as a sweetening and flavouring agent in the food, tobacco and pharmacy industries. The main active ingredient of liquorice is the triterpenoid saponin, glycyrrhizin, which is a mixture of calcium, magnesium and potassium salts of glycyrrhizic acid (GA). Glycyrrhizic acid is composed of an aglycone, that is 18β-glycyrrhetinic acid (GE), and a D-glucuronic acid dimer. The aim of this review is to discuss some aspects of the activity of glycyrrhetinic acid and its derivatives in infectious diseases.State of knowledge.The pentacyclic system of glycyrrhetinic acid consists of condensed six-membered rings with a hydroxyl group at C-3, a carboxyl moiety at C-30 and a ketone functional group at C-11. Considering the presence of the above mentioned functional groups, many structural transformations have been proposed, including those by way of esterification, alkylation and reduction reactions. The introduction of various chemical residues into its structure, as well as the modification of the glycyrrhetinic acid in its pentacyclic triterpene skeleton, has led to the generation of compounds with many valuable antimicrobial, anti-parasitic, antiviral properties and modified lipophilic parameters.Summary.In summary, glycyrrhetinic acid derivatives appear to have promise as active pharmaceutical ingredients that contain a wide range of biological and pharmacological properties.
Discriminant model possibility of occurrence pubertal uterine bleeding in girls depending on the characteristics of the structure and size of the body
Authors: Chaika Grigoriy , Kucherenko Oksana 
Published: March 2018

Abstract
In this paper, based on the performance characteristics of the structure and size of the body, and through step discriminant analysis, we have built an accurate and highly informative model of the possibility of pubertal uterine bleeding in a general population of girls aged from 14 to 18 years, and as broken down into groups 14-15 and 16-18 years. In the total group of girls of 14-18 years and notably in girls 16-18 years, indicators of skin thickness and fat fold are consistent with such a possibility, while in girls 14-15 years old, indicators of body diameter, width of distal epiphysis of long bones of the limbs and encompassing body size, show correlation with pubertal uterine bleeding. The largest contribution to discrimination, regardless of the age groups, is, however, the value of the fat component of body weight.
The influence of 1.4-naphtoquinone derivative and of vitamin E on nitroso-oxidative processes in digestive organ mucous membranes under the conditions of cyclooxygenase blockage, and against the background of low intensity X-ray irradiation
Authors: Ilnytska Khrystyna , Datsyuk Leonid , Novikov Volodymyr , Denysenko Nataliya , Sklyarov Alexandr 
Published: March 2018

Abstract
In recent years, the influence of chronic low intensity irradiation on the human body has increased. This is mediated not only by the consequences of technogenic catastrophies, but also due to application of radiation therapy of of radiation usage in industry. Hence, we investigated the influence of 1.4-naphtoquinone and vitamin Е on the nitroso-oxidative processes in the digestive organ mucous membranes, while affected by low intensity X-ray irradiation alone and in combination with the experimental blockage of COX, in rats. Our results show that X-ray irradiation of a total dose of 20 sGy during twenty days, induced an increase of the oxidative processes, as well as an increase in the activity of iNOS and myeloperoxidase in the mucous membranes of the stomach, small and large intestine. Both the effect of vitamin E and a 1.4-naphtoquinone derivative on the background of low intensity X-ray irradiation, and under the simultaneous effect of X-ray irradiation and COX blockage, brought about a decrease of the level of oxidative processes and of iNOS activity, whereas MPO activity increased. We also noted that the effect of vitamin E on the background of X-ray irradiation more significantly increased both the activity of SOD and catalase, when compared to the induced effect of the 1.4-naphtoquinone derivative. Under the conditions of COX-1/COX-2 blockage (as induced by way of indomethacin administration), against the background of X-ray irradiation, the content of TBA-active products (in the stomach and small intestine mucous membranes), the level of iNOS activity and the sum of nitrites and nitrates, were lower than that of independent effect. Тaking into account the prominent antioxidant and anti-inflammatory attributes of 1.4-naphtoquinone-3-[3-(3.5-di-tret-butyl-4-hydroxy-phenyl)-1.4-dihydronaphtalene-2-aminoil] butyrate, when compared to the effect of sole administration of vitamin E, both under the conditions of X-ray irradiation alone, and the simultaneous effect of X-ray irradiation and COX blockage, this derivative may be considered suitable as a perspective radiprotectant.
The connection of hydronephrosis and microcirculation deterioration
Authors: Vorobets Dmytro 
Published: March 2018

Abstract
In this study, we have analyzed the influence of hydronephrosis upon the microcirculation system, in situations of pyeloureteral junction obstruction. Herein, bulbar conjunctiva has been chosen as the object of this biomicroscopic study because of its simplicity and the method availability in clinic practice. In fulfilling this work, we ascertained the connections between extravascular, intravascular, vascular and general conjunctival indices of the patients before radical and paliatic correction of the pyeloureteral junction obstruction (i.e. by open and laparoscopic pyeloplasty, endopyelotomy, laser resection and balloon dilatation). We concluded that, apart from the proved deterioration of kidney function, systemic deteriorations of microcirculation may be observed in situations of clinically marked hydronephrosis, according to the results of radioisotope renography and excretory urography.
Hypertension in pediatric dentistry practice
Authors: Rosiak Joanna , Kubic-Filiks Beata , Szymanska Jolanta 
Published: March 2018

Abstract
The authors discuss the factors coexistent with hypertension both in children and youth, as well as the treatment methods and possible symptoms that might appear in the oral cavity. In the work, the authors emphasize that there is a need for cooperation between the general practitioner, a cardiologist and a dentist, so as to provide an early diagnosis and effective treatment, as well as to prevent complications with regard to hypertension itself and the drugs used in treatment. The discussion is based on a review of the most recent works in the field.
The fluctuation of free amino acids in serum during acute ischemic stroke
Authors: Szpetnar Maria , Hordyjewska Anna , Malinowska Iwona , Golab Piotr , Kurzepa Jacek 
Published: March 2018

Abstract
Currently, little data exists regarding the involvement of free amino acids (AA) in the pathogenesis of ischemic stroke (IS). Thus, our objective was to study the degree of the degree of fluctuation of free amino acids level in serum during the acute phase of IS. The study consisted of eighteen patients (female/male: 10/8; age: 73.1 ± 4.1) with acute IS that was confirmed by way of computed tomography, while twelve sex and age matched individuals were assigned as control group. During the study period, the patients did not receive any supplemental amino acids therapy that could affect the obtained results. The venous blood was obtained after >3 hours fasting at two time-points; time-point 1 – at admission to the hospital; time-point 2 – on day 5 from stroke onset. The blood for control purposes was collected only once, and the blood collection at time-point 1 was done before thrombolytic treatment (nine patients). The amino acids were identified using the Amino Acids Analyser (AAA 400) by INGOS Corp., Praha, Czech Republic. Our results revealed a statistically significant increase of glutamate, cystine and methionine on day 1 of stroke, in comparison to control, whereas, proline level was decreased on day 1 of stroke – in comparison to control serum. On comparing day 5 to the initial day of IS, elevation was observed of levels of asparagine, glycine, tyrosine, arginine, threonine, valine, leucine and phenylalanine. It can be said, then, that ischemic stroke induces both essential and nonessential amino acid fluctuations. Moreover, the decrease in proline and glutamine serum level with the simultaneous increase in the concentration of branch chain amino acids, Glu and Thr suggests a violent mobilization of the body’s proteins. Thus, a decrease of Pro and a simultaneous increase of Glu serum level could be considered as a marker of acute IS.
Tribological characteristics of dental metal biomaterials
Authors: Walczak Mariusz , Drozd Kazimierz 
Published: March 2018

Abstract
The paper is a report of the examination of the tribological wear characteristics of certain dental metal biomaterials. In the study, tests were undertaken on the following materials: 316L steel, NiCrMo alloy, technically pure titanium (ASTM-grade 2) and Ti6Al4V ELI alloy (ASTM-grade 5). The tribological tests were performed in artificial saliva to determine the coefficient of friction and wear factor; the traces of wear were then ascertained through SEM. The significance of variations in the wear factor, was subsequently assessed by the U Mann-Whitney test. The resistance to wear in the ball-on-disc test under in vitro conditions was observed for the tested materials in the following order: NiCrMo>316L>Ti6Al4V>Ti grade 2.
Status of rats myocardium under subchronic mercury exposure and its pharmacological correction
Authors: Rostislav Kaminsky F. , Liudmyla Sokurenko M. , Yuri Chaikovsky B. 
Published: March 2018

Abstract
The article is devoted to the characteristics of the myocardium restructuring under the influence of 0.01 LD50 mercury (II) chloride, in rats, under subchronic exposure, and the correction of the detected changes. In the work, the structural and metabolic reorganization of myocardium was studied by way of general histological, histochemical and electron microscopic techniques. Herein, administration of Unithiolum reduces the severity of reactions to toxic effects of mercury salts: decreases the intensity of inflammation in the myocardium, improves microcirculation, connective tissue and mitochondrial membranes status and reduces cardiomyocytes apoptosis. Quercetinum has a normalizing effect on the myocardium structure, reduces energy imbalance in the myocardium, and stabilizes mitochondrial membranes. Both Unithiolum and Quercetinum promote intracellular ultrastructures recovery in cardiac myocytes and in endothelial cells, and enhance the regeneration of myofibrils.
Modern kinetic spectrophotometric procedure for estimation of furosemide drug as bulk form and in pharmaceuticals preparations
Authors: Al-Rufaie Mohauman Mohammad 
Published: March 2018

AbstractA simple, rapid, sensitive, inexpensive and easy to perform kinetic spectrophotometric procedure for the investigation of trace quantities of the drug, furosemide (FRO), as bulk and in the pharmaceutical preparations, has been improved upon. The enhanced method was depended on the fashioning of the Schiff ‘s base by the reaction of the aldehyde group present in the 5-sulfo salicylaldehyde reagent, and the primary amino group present in furosemide. The latter acts as a ligand for the formation of an intense colored complex with Co(II) in an acidic medium, with maximum absorption at 608 nm. In the work, kinetic spectrophotometrics were established through the fixed time method. Moreover, Beer’s law was applied on the range of concentration between 5-100 ppm, while the molar absorptivity and the Sandell sensitivity were 3.9295×104 l.mol−1cm−1, 0.008 μg.cm−2, respectively. The detection limit (LOD) was 2.133 µg/ml−1, and LOQ was 1.105 µg/ml−1. Ideal circumstances for all colour improvement were seen, and the suggested procedure has been effectively employed in investigating amounts of furosemide (FRO) in bulk forms and in pharmaceutical preparations (tablets, injection sample). Additives and general excipient materials did not affect the studied method. A statistical comparison between the results that were obtained from the reference method gave good agreement.
A Semi-automatic Method to Retrieve Twitter Accounts
Authors: Nocca Florence 
Published: March 2018

AbstractAlthough Twitter has become a major source of data, research still relies on heavy manual searches to find the accounts of a population of interest, such as members of Parliament, members of an association or candidates to an election. In this article, we propose a method to semi-automatically retrieve those accounts. After creating a pool of possible accounts through automatic web searches, we select a unique account for each member of a defined group. To do so, we use a simplified version of the minimax regret approach, on a score based on the account’s handle and the tweets’ content. We test this method to find the accounts of the candidates for the 2015 Spanish general elections and the members of the 57th House of Commons in the United Kingdom.
Genomic Locus Modulating IOP in the BXD RI Mouse Strains
Authors: King Rebecca , Li Ying , Wang Jiaxing , Struebing Felix L , Geisert Eldon E 
Published: March 2018

Abstract
Intraocular pressure (IOP) is the primary risk factor for developing glaucoma, yet little is known about the contribution of genomic background to IOP regulation. The present study leverages an array of systems genetics tools to study genomic factors modulating normal IOP in the mouse. The BXD recombinant inbred (RI) strain set was used to identify genomic loci modulating IOP. We measured the IOP in a total of 506 eyes from 38 different strains. Strain averages were subjected to conventional quantitative trait analysis by means of composite interval mapping. Candidate genes were defined, and immunohistochemistry and quantitative PCR (qPCR) were used for validation. Of the 38 BXD strains examined the mean IOP ranged from a low of 13.2mmHg to a high of 17.1mmHg. The means for each strain were used to calculate a genome wide interval map. One significant quantitative trait locus (QTL) was found on Chr.8 (96 to 103 Mb). Within this 7 Mb region only 4 annotated genes were found: Gm15679, Cdh8, Cdh11 and Gm8730. Only two genes (Cdh8 and Cdh11) were candidates for modulating IOP based on the presence of non-synonymous SNPs. Further examination using SIFT (Sorting Intolerant From Tolerant) analysis revealed that the SNPs in Cdh8 (Cadherin 8) were predicted to not change protein function; while the SNPs in Cdh11 (Cadherin 11) would not be tolerated, affecting protein function. Furthermore, immunohistochemistry demonstrated that CDH11 is expressed in the trabecular meshwork of the mouse. We have examined the genomic regulation of IOP in the BXD RI strain set and found one significant QTL on Chr. 8. Within this QTL, there is one good candidate gene, Cdh11.
Closure of patent ductus arteriosus with oral acetaminophen in preterm neonates: A randomized trial
Authors: Babaei Homa , Nemati Rahele , Daryoshi Hooman 
Published: March 2018

Introduction: Patent ductus arteriosus (PDA) is one of the most common cardiac problems in preterm neonates which could lead to morbidities, such as chronic lung disease, intraventricular hemorrhage and retinopathy. The aim of this study was to evaluate the effect of oral acetaminophen on closure of PDA in preterm neonates.
Methods: Sixty-nine neonates with significant PDA (confirmed through echocardiography) were recruited in this study. Ibuprofen and indomethacin were contraindicated in these neonates These newborns were randomly divided into two groups of cases (n=36) and controls (n=33). The case group was treated with oral acetaminophen at a dose of 15 mg/kg/dose every 6 hours for 72 hours. The control group did not receive any intervention. After 72 hours, both groups were re-evaluated by echocardiography. In case of failed closure of PDA, the second course of treatment would be administration of acetaminophen. The main outcome of this study was to evaluate the rate of closure of PDA and the side effects of the acetaminophen.
Results: The overall rate of PDA closure in the acetaminophen-receiving group was 94.4%; the ductus arteriosus was closed in 75% of patients with the first course of treatment. Moreover, 19.4% of patients did not respond to the first course of the treatment but their ductus arteriosus was closed with the second course of acetaminophen treatment. Of the patients, 5.6% did not respond to both courses of acetaminophen treatments. For the control group, the closure rate of PDA was 15.1%.
Conclusion: The results of the study showed that oral acetaminophen is an effective alternative treatment for PDA in preterm neonates.
Successful treatment with home care during the second half of a twin pregnancy complicated by a short cervix: A case report
Authors: Zarei Mohammad , Zahedifard Tahereh , Nori Reza 
Published: March 2018

Introduction: Twin pregnancies are associated with a risk of premature delivery.
Case presentation: A 34-year-old primiparous female patient with twin pregnancy presented in the 26th week of pregnancy with a cervical length of 11 mm, with prolapse of membranes. The patient received specialized bed rest and support, and the pregnancy was successfully completed at 36 weeks and 5 days.
Conclusion: In the second half of the pregnancy, due to the risk of emergency cervical cerclage, expectant management seems an appropriate and safe approach.