bluuebunny/crossref_metadata_2025_split huggingface dataset:
36-month Evaluation of Non-carious Cervical Lesion Restorations Using Different Modes of Universal Adhesive
Authors: Tepe Hatice , Çeliksöz Özge , Yaman Batu Can 
Published: December 2024

Abstract

Objective
To evaluate the 36-month clinical performance of Single Bond Universal Adhesive (SBU; 3M ESPE, Germany) in non-carious cervical lesions (NCCLs) using different modes of adhesion according to the FDI criteria.
Materials and methods
In this study, the SBU Adhesive was applied to 246 NCCLs of 25 patients using different modes of adhesion: Self-etch (SE), selective-enamel-etching (SLE), and etch-and-rinse (ER). All lesions were restored with the same nanohybrid resin composite. The restorations were evaluated at the 1st, the 6th, 12th, 18th, and 36th month using the FDI criteria: marginal staining, fracture of material and retention, marginal adaptation, post-operative sensitivity and tooth vitality, recurrence of caries erosion and abfraction, and tooth integrity criteria. The differences between SE, SLE, and ER groups were tested using the Kruskal-Wallis and Mann-Whitney U tests where a value of p < 0.05 was accepted as a criterion for statistical significance.
Results
After 36-month the recall rate was 96%. The retention loss rates were 29.33% for SE, 16.66% for SLE, and 3.89% for ER modes. Interactions between time periods and adhesive modes were found to be statistically significant (p < 0.05) for all FDI criteria. ER mode performed significantly better than SE mode for marginal staining, fracture of material and retention, marginal adaptation and recurrence of caries erosion and abfraction criteria after the 36th month (p < 0.05). There was no statistically significant difference between SE and SLE mode (p > 0.05), nor between SLE and ER mode (p > 0.05).
Conclusions
After the 36-month evaluation of all adhesive modes used in the study, restorations performed with the ER adhesion mode were clinically good (2), while those performed with the SE adhesion mode and SLE adhesion mode were clinically satisfactory (3) according to the FDI criteria.
Clinical Relevance:
Restorations performed with the SE adhesion mode of universal adhesives exhibit clinically acceptable behavior after 36 months of evaluation, although with less success than those performed with the ER adhesion mode.
Th17 and effector CD8 T cells relate to disease progression in amyotrophic lateral sclerosis: a case control study
Authors: Itou Tatsuo , Fujita Koji , Okuzono Yuumi , Warude Dnyaneshwar , Miyakawa Shuuichi , Mihara Yoshimi , Matsui Naoko , Morino Hiroyuki , Kikukawa Yusuke , Izumi Yuishin 
Published: December 2024

Abstract

The immune system has garnered attention due to its association with disease progression in amyotrophic lateral sclerosis (ALS). However, the role of peripheral immune cells in this context remains controversial. Here, we conducted single-cell RNA-sequencing of peripheral blood mononuclear cells to comprehensively profile immune cells concerning the rate of disease progression in patients with ALS. Our analysis revealed increased frequencies of T helper 17 cells (Th17) relative to regulatory T cells, effector CD8 T cells relative to naïve CD8 T cells, and CD16highCD56low mature natural killer cells relative to CD16lowCD56high naïve natural killer cells in patients with rapidly progressive ALS. Additionally, we employed serum proteomics through a proximity extension assay combined with next-generation sequencing to identify inflammation-related proteins associated with rapid disease progression. Among these proteins, interleukin-17A correlated with the frequency of Th17, while killer cell lectin-like receptor D1 (CD94) correlated with the frequency of effector CD8 T cells. These findings further support the active roles played by these specific immune cell types in the progression of ALS.
Autologous platelet-rich plasma ovarian injection was associated with increased oocyte acquisition in patients with poor ovarian response: a retrospective propensity-matched study
Authors: Li Qian , Li Jing , Liu Jiawen , Chang Yajie , Liu Yingying , Zou Lina , Fang Cong , Liang Xiaoyan 
Published: December 2024

Abstract

Background Women with poor ovarian response (POR) tended to have lower success rates for IVF/ICSI due to fewer oocytes retrieved. Autologous platelet-rich plasma (PRP) had been proposed to improve ovarian response.Method This study aims to evaluate the impact of autologous PRP ovarian injections on oocyte retrieval numbers and other reproductive outcomes in IVF/ICSI cycles among infertile women with POR, as defined by the Bologna criteria. Conducted at the Reproductive Center of the Sixth Affiliated Hospital of Sun Yat-sen University, this retrospective analysis involved a total of 1,833 oocyte retrieval cycles. Among these, 91 cycles involved patients who received autologous PRP injections, while 261 cycles were included in the control group after applying propensity score matching.Results The PRP group showed a significant increase in the number of follicles ≥ 14mm(2.96 ± 1.79 versus 2.26 ± 1.44, P < 0.001), retrieved oocytes(2.86 ± 1.88 versus 2.07 ± 1.78, P < 0.001), and normally fertilized zygotes(1.73 ± 1.42 versus 1.337 ± 1.44, P = 0.044) compared to the control group. Although the number of transferable embryos(1.34 ± 1.21 versus 1.07 ± 1.26, P = 0.079) and high-quality embryos(1.09 ± 1.16 versus 0.83 ± 1.13, P = 0.066) was higher in the PRP group, these differences were not statistically significant. Multivariable logistic regression identified PRP injection(odds ratio [OR] 3.655, 95% confidence interval [CI] 0.324–1.079, P < 0.001), AMH levels(OR 4.096, 95% CI 0.949–2.701, P < 0.001), and total gonadotropin dose( OR 2.899, 95% CI < 0.001–0.001, P = 0.004) as independent predictors for oocyte retrieval.Conclusion Autologous PRP ovarian injection was associated with an increased number of oocytes retrieved in patients with poor response. While embryo quality improvement was not significant, PRP shows potential for enhancing reproductive outcomes in this population. Further randomized controlled trials are warranted.
Configurations of Training Transfer Performance in Near and Far Contexts: A Fuzzy-set Qualitative Comparative Analysis of Values-Driven Leadership Development
Authors: Song Hongfeng , Zhang Yuqing , Hu Anqi , Liu Xuanling 
Published: December 2024

Abstract

Modern enterprises frequently utilize various training activities to enhance employees’ job-related skills, and the success of training programs largely depends on effective training transfer. High training transfer rates are crucial for business development and achieving a favorable return on investment. Therefore, exploring pathways to achieve high training transfer holds substantial theoretical and practical significance. Through integrative theoretical perspectives, this study constructs a model of influencing factors of training transfer. Taking 216 members of the first and second phases of the State Grid Values-Driven Leadership Development Program as research objects, we employed a combination of NCA and fsQCA methods to identify various configurations that affect both near and far training transfer performance. The findings indicate that: (1) Transfer design is necessary for high training transfer performance in both near and far ends and plays an indispensable role in generating high training transfer performance. (2) Three configurations can generate high training transfer performance: organization leads to compensate for individual characteristics, organizational guidance to individuals, and individual-organization-environment co-driving. The latter configuration covers the largest number of participants, indicating the importance of fostering cooperation and mutual support among these three elements to enhance positive interactions and improve training outcomes. (3) The set composition of near and far ends configurations varies, with project identification and team learning atmosphere having a more substantial impact on the near end. At the same time, execution instrumentality and organizational support play a more critical role in the long term. This study offers valuable theoretical and practical insights for optimizing the Values-Driven Leadership Development Program system and achieving high-quality training transformation.
Innovative fast and low-cost method for the detection of living bacteria based on trajectory
Authors: Perronno Paul , Claudinon Julie , Senin Carmen , Elcin-Guinot Serap , Wolter Lena , Makshakova Olga N. , Dumas Norbert , Klockenbring Dimitri , Lam-Weil Joseph , Noblet Vincent , Steltenkamp Siegfried , Römer Winfried , Madec Morgan 
Published: December 2024

Abstract

Detection of pathogens is a major concern in many fields like medicine, pharmaceutics, or agri-food. Most conventional detection methods require skilled staff and specific laboratory equipment for sample collection and analysis or are specific to a given pathogen. Thus, they cannot be easily integrated into a portable device. In addition, the time-to-response, including the sample collection, possible transport to the measurement equipment, and analysis, is often quite long, making real-time impossible. This paper presents a new approach that better fulfills industry needs in terms of integrated real-time wide screening of a large number of samples. It combines optical imaging, object detection and tracking, and machine-learning-based classification. For this study, three of the most common bacteria are considered. For all of them, living bacteria are discriminated from inert and inorganic objects (1µm latex beads), based on their trajectory, with a high degree of confidence. Discrimination between living and dead bacteria of the same species is also achieved. Finally, the method also successfully detects abnormal concentrations of a given bacterium compared to a standard baseline solution. However, there is still room for improvement, these results provide a proof of concept for this technology, which has strong application potential in infection spread prevention.
WITHDRAWN: The value of T2WI-based intratumoral and peritumoral edema radiomics in predicting IDH-1 genotype in gliomas
Authors: Tang Wei , Yang Weixin , Tang Lei , Zhai Zhaohua 
Published: December 2024

Abstract

Objective: To explore the preoperative prediction value of isocitrate dehydrogenase-1 (IDH-1) genotype in gliomas using T2WI peritumoral edema radiomics.
Methods: Preoperative T2WI images of 164 patients with glioma (WHO grade 2–4) confirmed by pathology were retrospectively analyzed, including wild-type IDH-1 (n = 106) and mutant IDH-1 (n = 58). All patients were randomly divided into training and validation cohorts in the ratio of 7:3. Radiomics features were extracted from tumor and peritumoral edema using 3D-slicer software. The least absolute shrinkage and selection operator (Lasso) method was used for feature selection and regularization. After obtaining the optimized radiomics features, multiple regression models of clinical model (A), intratumoral-only radiomics model (T), peritumoral edema–only radiomics model (E), intratumoral and peritumoral edema radiomics model (H), and clinical combined radiomics model (C) were established and cross-validated. The predictive performance of the model was evaluated by the area under the receiver operating characteristic (ROC) curve (AUC).
Result: Model E had a better prediction efficiency than model T, and model H had a better prediction performance than the single-region model, although without significant difference among the three groups (P > 0.05). Model C had the best prediction performance, with an AUC of 0.927 (95% CI: 0.88–0.97) and 0.870 (95% CI: 0.77–0.97), the sensitivity of 0.73 and 0.93, the specificity of 0.83 and 0.81, and the accuracy of 0.86 and 0.82 in the training and validation cohort, respectively. The difference between model C and model A was statistically significant (P< 0.05).
Conclusion: Radiomic models based on T2WI intratumoral and peritumoral edema can effectively predict the IDH-1 genotype of gliomas preoperatively.
Assembly of a Conductive Nanoparticle Polymer Nano Composite Thermal Insulation Film
Authors: Xing Baoyan , Ma Honfang , Dong Bingrong , Li Aijun , Zhao Jianguo , Ma Guibin 
Published: December 2024

Abstract

Organic-inorganic nano-composite films have attracted considerable attention due to their extraordinary properties, performance and applications. There have been few reports in the literature of conductive nano-composite organic-inorganic films. Herein an antimony tin oxide (ATO) polyethersulfone (PES) nano-composite conductive film has been assembled. First, the high conductive ATO nanoparticles were synthesized in the solid state and fully characterized using a variety of techniques focusing on its conductive properties. Next, a good dispersion reagent was selected to optimize conditions such as dispersion agent to ATO nanoparticle weight ratio, to generate maximum conductivity of the nanoparticle paste in solution. Oleic acid (OA) is a good dispersion agent, and the minimum resistance (R) is at an OA/ATO weight ratio at 0.5 in an NMP solution. Third, the ATO-PES nano-composite films were assembled by mixing a blended solution applied to the OA capped ATO nanoparticle solution with the polymer PES. Five different ATO composited films (4.5, 9.8, 18.8, 28.7 and 32.2%) were prepared under the same conditions but only the 32.2% weight of ATO film showed electronic conductivity at the OA/ATO weight ratio of 0.5. However, the conductivity is not homogenous, being more conductive at the bottom. The film becomes more homogenous in conductivity when the OA/ATO weight ratio is reduced to 0.19 and with 35.8% ATO. The measured top film resistance (R) is linear correlation to the film length, indicating that the film resistance is homogenous. The topography and current mapping of the film top shows the root mean square roughness (Rq) of the topography image is around 40 ± 2.5nm with agglomerates of densely packed ATO nanoparticles embedded into the polymer matrices in the film. The current map shows that the current is only present where nanoparticles are located. Thermogravimetric analysis shows that all ATO PES films are thermally stable films but only the 32.2% ATO film is conductive. A thermal radiation test showed that the film has excellent thermal insulation properties and the potential application in efficient building insulation and tent materials.
Magnetic resonance imaging signatures of neuroinflammation in major depressive disorder with religious and spiritual problems
Authors: Kaszás Alexandra , Kelemen Oguz , Kéri Szabolcs 
Published: December 2024

Abstract

Religious and spiritual (R/S) struggles, such as questioning of faith, existential and ethical concerns, and interpersonal conflicts, are associated with depressive symptoms. Neuroinflammation is critical in major depressive disorder (MDD) and is linked to stress associated with R/S problems. This study aimed to assess whether the presence of DSM-5 R/S problems contributes to neuroinflammation. We recruited 93 MDD patients and 93 healthy controls with and without R/S problems. MRI-based restricted fraction (RF) values, an index of neuroinflammation, were measured in the hippocampus, amygdala, and neocortex. Depression and anxiety were assessed using the Hamilton Depression and Anxiety Rating Scales (HAM-D, HAM-A), while R/S problems were quantified using the Religious and Spiritual Struggles Scale (RSS-14). Results revealed elevated RF values in the amygdala and hippocampus of healthy individuals and MDD patients with R/S problems relative to those without R/S problems, with the highest values in MDD patients with R/S problems. Importantly, R/S problems and depressive symptoms were found to be independent predictors of RF values in the amygdala and hippocampus but not in the cortex. Elevated cortical RF values were associated with MDD. These intriguing findings indicate that R/S struggles are not secondary manifestations of depression but may independently contribute to neurobiological changes, engaging the audience in further research and discussion.
Cardiac systolic and diastolic function in relation to cardiovascular risk factor distribution: a comparison of strain-rate imaging in Russian and Norwegian populations Heart-to-Heart: Norwegian-Russian multilevel educational collaboration in cardiovascular disease epidemiology
Authors: Rösner Assami , Kornev Mikhail , Caglayan Hatice Akay , Malyutina Sofia , Ryabikov Andrew , Schirmer Henrik , Kudryavtsev Alexander V 
Published: December 2024

Abstract

Background: Cardiovascular morbidity and mortality rates are high in Russia and it is likely that this reflects a similar impact on the general cardiac health of the population. The current study seeks to compare standard echocardiography and strain-based measurements between Russian and Norwegian populations, while also exploring their links to hemodynamic and risk factors.
Methods: This study included echocardiographic measurements of 1,192 participants from Arkhangelsk and Novosibirsk, Russia, and 917 from the Tromsø Study population, Norway. The sample included men and women aged 40–69 years. Normalcy, defined as the absence of hypertension or indicators of CVD, was observed in 840 individuals. We performed conventional echocardiography and analysed two-dimensional speckle-tracking longitudinal strains, including systolic, early-, and late-diastolic SR values. The study population was divided into four groups: normal, controlled hypertension, hypertensive blood pressure, and cardiac disease. Echocardiographic parameters were compared between the Russian and Norwegian populations,adjusted for age, sex, height, body mass index, blood pressure, heart rate (HR), atrial fibrillation (AF), smoking, pulmonary hypertension, and serum values for total, LDL (low density lipoprotein), and HDL (high density lipoprotein) cholesterol; triglycerides; creatinine; high-sensitivity C-reactive protein; and HbA1C.
Results: Russians showed a tendency towards lower longitudinal systolic functional parameters, which were most prominent in the normotensive group. However, these differences became insignificant after adjusting for parameters that influence pre- and after-loads. Russians also had a lower stroke volume, higher HR, higher left atrial volume, lower A, and higher E/A ratio, indicating a higher incidence of diastolic dysfunction in the Russian population that persisted after adjustments.
Conclusion: After adjusting for factors that influence cardiac function, there were no differences in systolic functional parameters betweenthe Norwegian and Russian populations. However, differences in diastolic parameters, which persisted after adjusting for conventionally influential factors, indicated unexplained underlying causes of diastolic dysfunction in the Russian population.
The psychological experience of Chinese male master of nursing students: A qualitative study
Authors: Wang Zezhou , Liu Yan , Fang Kui , Dong Xue , Dong Yutong 
Published: December 2024

Abstract

Background: With the progress of graduate education in China, the development of society, and the deepening of medical reforms, professional development has become an important trend in cultivating high-level nursing talents. An increasing number of male graduate students are joining the nursing workforce. Investigating the experiences of male nursing graduate students during their learning process, analyzing the relevant factors affecting their education, and exploring potential solutions can provide references for nursing educators and administrators. This contributes to the further improvement of clinical nursing quality and the advancement and development of the nursing discipline.
Aim and objectives: This study aims to explore the emotional experience of Chinese male nursing postgraduates during their study through semi-structured interviews.
Design: A qualitative interview study.
Methods: Purposeful sampling was utilized to invite 11 male nursing master's students from nine provinces in China, with an average age of 25.36 ± 3.35 years. The participants comprised 64% with a professional master's degree and 36% with an academic master's degree; 45% were in the first year, 36% in the second, and 27% in the third. The COREQ checklist was used.
Results: Five key themes emerged : The improvement of knowledge and ability; the pressure of scientific research; the pressure of time and economy; confusion in career development, and low social recognition.
Conclusion: Male nursing graduate students can improve their abilities through the acquisition of specialized knowledge. However, they must navigate various challenges while seeking respect and recognition. Nursing educators and administrators should prioritize ideological education for male nursing graduate students, foster positive learning experiences, and gradually refine the cultivation methods for nursing master's students to nurture high-quality nursing resources for the development of the medical profession.
Cytokeratin Immunohistochemistry-Supervised Deep Learning for Detecting Breast Cancer Lymph Node Metastases and Evaluation of its Clinical Utility
Authors: Chou Yueh-Hung , Wu Chien-Hui , Chang Min-Hsiang , Tsai Hsin-Hsiu , Peng Yi-Ting 
Published: December 2024

Abstract

Lymph node status is an indispensable examination for breast cancer therapy. To detect small, inconspicuous metastatic carcinomas, pathologists usually require immunohistochemical (IHC) staining for cytokeratin (CK). Here, we proposed an IHC-supervised algorithm to create virtual CK masks in lymph node hematoxyline and eosin (H&E) images and evaluated its clinical utility. We enrolled 194 patients with breast cancer surgery-related axillary lymph nodes containing variously sized metastases. The deep learning network, Unet++ with EfficientNet-B7 as the backbone, was trained with the ground truth extracted from consecutive or re-stained CK. At the pixel level, the model had high accuracy (0.98 on average) and decent recall (0.64 on average) and performed best in macrometastasis, followed by micrometastasis and isolated tumor cells (ITC). At the whole-slide image (WSI) level, all 25 slides with macro-metastases and most micro-metastatic (15/16) were classified correctly. For ITC, 17/19 patients were identified; however, certain benign cells were misrecognized in 18/19 negative patients. In clinical settings, artificial intelligence can help pathologists detect micrometastatic carcinoma and significantly decrease reading time. IHC-supervised deep learning is robust and efficient, providing substantial, high-quality ground truth. The virtual CK masks and augmented WSI system enhanced pathologists’ ability to search for tumors in the lymph nodes.
Automated Characterization of Abdominal MRI Exams Using Deep Learning
Authors: Kim Joonghyun , Chae Allison , Duda Jeffrey , Borthakur Ari , Rader Daniel , Gee James C. , Kahn Charles E. , BioBank Penn Medicine , Witschey Walter R. , Sagreiya Hersh 
Published: December 2024

Abstract

Advances in magnetic resonance imaging (MRI) have revolutionized disease detection and treatment planning. However, as the volume and complexity of MRI data grow with increasing heterogeneity between institutions in imaging protocol, scanner technology, and data labeling, there is a need for a standardized methodology to efficiently identify, characterize, and label MRI sequences. Such a methodology is crucial for advancing research efforts that incorporate MRI data from diverse populations to develop robust machine learning models. This research utilizes convolutional neural networks (CNNs) to automatically classify sequence, orientation, and contrast, specifically tailored for abdominal MRI. Three distinct CNN models with similar backbone architectures were trained to classify single image slices into one of 12 sequences, 4 orientations, and 2 contrast classes. Results derived from this method demonstrate high levels of performance for the three specialized CNN models, with model accuracies for sequence, orientation, and contrast of 96.9%, 97.4%, and 97.3%, respectively.