bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brazilian Version of the Body Appreciation Scale (BAS) for Young Adolescents
Authors: Moreira Gabriela Salim Xavier , Lorenzato Luciana , Neufeld Carmem Beatriz , Almeida Sebastião Sousa 
Published: June 2018

AbstractThe present study developed a Brazilian adaptation of the BAS for young adolescents, testing its factor structure by the Confirmatory Factor Analysis (CFA), concurrent and criterion validity, and its internal consistency. Participants were 347 adolescents (171 male and 176 female, aged between 10 and 13 years old). Three psychologists experts in psychological evaluation and three teachers of Portuguese of elementary school also participated for the adaptation stage of the items in order to be properly understood by the sample age group. There were few changes from the version culturally adapted for the Brazilian adult population. Cronbach’s alpha coefficients were satisfactory for the general population and both sexes (.804; female =.851; male =.752). The one-factor model of the BAS was confirmed by the confirmatory factor analysis with good indicators for the measurements of adjustment to the model, χ2= 77.9; GFI = 0.967; NFI = 0.940, CFI = 0.979; TLI = 0.968; RMSEA;.038). The convergent validity analyzes revealed significant correlations between BAS scores and BMI (r= –.230;p< .001) and between the first and body image satisfaction (r = .309;p< .001). The BAS version for Brazilian young adolescents had adequate levels of validity and reliability, keeping the one-dimensional structure which indicates its use in Brazilian adolescent’s samples.
The Strengths and Difficulties Questionnaire -Dysregulation Profile, Non-Suicidal Self-Injury Behaviors and the Mediating Role of Stressful Life Events
Authors: Caro-Cañizares Irene , Díaz de Neira-Hernando Mónica , Pfang Bernadette , Baca-Garcia Enrique , Carballo Juan J. 
Published: June 2018

AbstractNon-suicidal self-injury (NSSI) behaviors are self-injurious behaviors inflicted without intending death. Literature has shown the relationship between stressful life events (SLE) and NSSI behaviors. The Strengths and Difficulties Questionnaire-Dysregulation Profile (SDQ-DP) is defined as an index of self-regulatory problems, related to higher risk for suicidal ideation and attempts in adolescents. In this study the relationship between SDQ-DP and NSSI behaviors, mediated by SLE in a clinical sample of children and adolescents is analyzed. A cross-sectional study was conducted on 239 subjects (aged from 11 to 17) to test the mediation model. SDQ-DP significantly correlates with NSSI behaviors (Wald = 6.5477, p = .0105); SDQ-DP significantly correlates with SLE (T = 5.7229, p < .001); SLE significantly correlates NSSI behaviors, and the relation remains significant whilst controlling for SDQ-DP (Wald = 4.1715, p = .041); the relation between SDQ-DP and NSSI behaviors stops being significant whilst controlling for the potential mediator (SLE) (Wald = 2.9951, p = .0835). Study of indirect effect supports the mediation model (.0585 CI [.0016, .1266]). Findings are compatible with the complete mediation scenario. These results point out the importance of self-regulatory problems in coping strategies with regards to SLE and the development of NSSI behaviors.
Temperature Response of Respiration Across the Heterogeneous Landscape of the Alaskan Arctic Tundra
Authors: Wilkman Eric , Zona Donatella , Tang Yanfei , Gioli Beniamino , Lipson David A. , Oechel Walter 
Published: June 2018

AbstractPredictions of the response of ecosystem respiration to warming in the Arctic are not well constrained, partly due to the considerable spatial heterogeneity of these permafrost‐dominated areas. Accurate calculations of in situ temperature sensitivities of respiration (Q10) are vital for the prediction of future Arctic emissions. To understand the impact of spatial heterogeneity on respiration rates and Q10, we compared respiration measured from automated chambers across the main local polygonized landscape forms (high and low centers, polygon rims, polygon troughs) to estimates from the flux‐partitioned net ecosystem exchange collected in an adjacent eddy covariance tower. Microtopographic type appears to be the most important variable explaining the variability in respiration rates, and low‐center polygons and polygon troughs show the greatest cumulative respiration rates, possibly linked to their deeper thaw depth and higher plant biomass. Regardless of the differences in absolute respiration rates, Q10 is surprisingly similar across all microtopographic features, possibly indicating a similar temperature limitation to decomposition across the landscape. Q10 was higher during the colder early summer and lower during the warmer peak growing season, consistent with an elevated temperature sensitivity under colder conditions. The respiration measured by the chambers and the estimates from the daytime flux‐partitioned eddy covariance data were within uncertainties during early and peak seasons but overestimated respiration later in the growing season. Overall, this study suggests that it is possible to simplify estimates of the temperature sensitivity of respiration across heterogeneous landscapes but that seasonal changes in Q10 should be incorporated into model simulations.
Distinct patterns and processes of abundant and rare eukaryotic plankton communities following a reservoir cyanobacterial bloom
Authors: Xue Yuanyuan , Chen Huihuang , Yang Jun R , Liu Min , Huang Bangqin , Yang Jun 
Published: June 2018

Abstract
Plankton communities normally consist of few abundant and many rare species, yet little is known about the ecological role of rare planktonic eukaryotes. Here we used a 18S ribosomal DNA sequencing approach to investigate the dynamics of rare planktonic eukaryotes, and to explore the co-occurrence patterns of abundant and rare eukaryotic plankton in a subtropical reservoir following a cyanobacterial bloom event. Our results showed that the bloom event significantly altered the eukaryotic plankton community composition and rare plankton diversity without affecting the diversity of abundant plankton. The similarities of both abundant and rare eukaryotic plankton subcommunities significantly declined with the increase in time-lag, but stronger temporal turnover was observed in rare taxa. Further, species turnover of both subcommunities explained a higher percentage of the community variation than species richness. Both deterministic and stochastic processes significantly influenced eukaryotic plankton community assembly, and the stochastic pattern (e.g., ecological drift) was particularly pronounced for rare taxa. Co-occurrence network analysis revealed that keystone taxa mainly belonged to rare species, which may play fundamental roles in network persistence. Importantly, covariations between rare and non-rare taxa were predominantly positive, implying multispecies cooperation might contribute to the stability and resilience of the microbial community. Overall, these findings expand current understanding of the ecological mechanisms and microbial interactions underlying plankton dynamics in changing aquatic ecosystems.
Dissemination and persistence of extended-spectrum cephalosporin-resistance encoding IncI1-blaCTXM-1 plasmid among Escherichia coli in pigs
Authors: Abraham Sam , Kirkwood Roy N , Laird Tanya , Saputra Sugiyono , Mitchell Tahlia , Singh Mohinder , Linn Benjamin , Abraham Rebecca J , Pang Stanley , Gordon David M , Trott Darren J , O’Dea Mark 
Published: June 2018

Abstract
This study investigated the ecology, epidemiology and plasmid characteristics of extended-spectrum cephalosporin (ESC)-resistant E. coli in healthy pigs over a period of 4 years (2013–2016) following the withdrawal of ESCs. High carriage rates of ESC-resistant E. coli were demonstrated in 2013 (86.6%) and 2014 (83.3%), compared to 2015 (22%) and 2016 (8.5%). ESC resistance identified among E. coli isolates was attributed to the carriage of an IncI1 ST-3 plasmid (pCTXM1-MU2) encoding blaCTXM-1. Genomic characterisation of selected E. coli isolates (n = 61) identified plasmid movement into multiple commensal E. coli (n = 22 STs). Major STs included ST10, ST5440, ST453, ST2514 and ST23. A subset of the isolates belong to the atypical enteropathogenic E. coli (aEPEC) pathotype that harboured multiple LEE pathogenic islands. pCTXM1-MU2 was similar (99% nt identity) to IncI1-ST3 plasmids reported from Europe, encoded resistance to aminoglycosides, sulphonamides and trimethoprim, and carried colicin Ib. pCTXM1-MU2 appears to be highly stable and readily transferable. This study demonstrates that ESC resistance may persist for a protracted period following removal of direct selection pressure, resulting in the emergence of ESC-resistance in both commensal E. coli and aEPEC isolates of potential significance to human and animal health.
Magnolin promotes autophagy and cell cycle arrest via blocking LIF/Stat3/Mcl-1 axis in human colorectal cancers
Authors: Yu Haiyang , Yin Shuangshuang , Zhou Shiyue , Shao Yingying , Sun Jiachen , Pang Xu , Han Lifeng , Zhang Yi , Gao Xiumei , Jin Chengyun , Qiu Yuling , Wang Tao 
Published: June 2018

AbstractMagnolin is a multi-bioactive natural compound that possesses underlying anti-cancer properties. However, the mechanisms underlying remain to be elucidated. Here, we report the role of magnolin in suppressing human colorectal cancer (CRC) cells via activating autophagy and cell cycle arrest in vitro and in vivo. Pre-treatment of cells with specific autophagy inhibitor (3-methyladenine) or knockdown of endogenous LC-3B by siRNA significantly abrogates magnolin-induced cell cycle arrest. Molecular validation mechanistically shows that magnolin-induced autophagy and cell cycle arrest in CRC cells is correlated with decreased transcriptional levels of leukemia inhibitory factor (LIF), and we further find that inhibition of LIF decreases phosphorylation level of Stat3 and represses transcriptional expression of Mcl-1. Furthermore, magnolin-induced autophagy and cell cycle arrest suppress the growth of xenograft colorectal tumors without apparent toxicity. Finally, we evaluate the clinical correlation of LIF/Stat3/Mcl-1 in CRC patient tissues. As expected, LIF, p-Stat3, and Mcl-1 levels are high in CRC tissue but are scarcely found in normal colon tissue. High positive expressions of LIF or Mcl-1 are associated with poor prognosis. Doubly positive cases have shown the worst outcome. Taken together, our results have clarified a novel molecular mechanism whereby magnolin induces autophagy and cell cycle arrest through LIF/Stat3/Mcl-1 pathway in CRCs. Our results also have revealed that magnolin has a promising therapeutic potential in CRCs.
Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice
Authors: Harder Jeffrey M. , Williams Pete A. , Soto Ileana , Foxworth Nicole E. , Fernandes Kimberly A. , Freeburg Nelson F. , Libby Richard T. , John Simon. W. M. 
Published: June 2018

AbstractThe cJun N-terminal kinases (JNKs; JNK1, JNK2, and JNK3) promote degenerative processes after neuronal injury and in disease. JNK2 and JNK3 have been shown to promote retinal ganglion cell (RGC) death after optic nerve injury. In their absence, long-term survival of RGC somas is significantly increased after mechanical optic nerve injury. In glaucoma, because optic nerve damage is thought to be a major cause of RGC death, JNKs are an important potential target for therapeutic intervention. To assess the role of JNK2 and JNK3 in an ocular hypertensive model of glaucoma, null alleles of Jnk2 and Jnk3 were backcrossed into the DBA/2J (D2) mouse. JNK activation occurred in RGCs following increased intraocular pressure in D2 mice. However, deficiency of both Jnk2 and Jnk3 together did not lessen optic nerve damage or RGC death. These results differentiate the molecular pathways controlling cell death in ocular hypertensive glaucoma compared with mechanical optic nerve injury. It is further shown that JUN, a pro-death component of the JNK pathway in RGCs, can be activated in glaucoma in the absence of JNK2 and JNK3. This implicates JNK1 in glaucomatous RGC death. Unexpectedly, at younger ages, Jnk2-deficient mice were more likely to develop features of glaucomatous neurodegeneration than D2 mice expressing Jnk2. This appears to be due to a neuroprotective effect of JNK2 and not due to a change in intraocular pressure. The Jnk2-deficient context also unmasked a lesser role for Jnk3 in glaucoma. Jnk2 and Jnk3 double knockout mice had a modestly increased risk of neurodegeneration compared with mice only deficient in Jnk2. Overall, these findings are consistent with pleiotropic effects of JNK isoforms in glaucoma and suggest caution is warranted when using JNK inhibitors to treat chronic neurodegenerative conditions.
Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis
Authors: Guo Yuanxu , Min Zixin , Jiang Congshan , Wang Wei , Yan Jidong , Xu Peng , Xu Ke , Xu Jing , Sun Mengyao , Zhao Yitong , Hussain Safdar , Zhang Rui , Wang Quancheng , Han Yan , Zhang Fujun , Zhu Wenhua , Li Dongmin , Meng Liesu , Sun Jian , Lu Shemin 
Published: June 2018

AbstractOsteoarthritis (OA) is the most common form of arthritis involving major structural changes of peripheral joints and local or systemic inflammation and in lack of therapeutic approaches because of complexity of underlying molecular basis. Our previous work showed that HS6ST2, an enzyme involved in the transfer of sulfate, is downregulated in cartilage tissues of OA patients compared with normal donors, but little is known about its regulatory mechanism. In this study, we demonstrated that the expression of HS6ST2 was lower in OA-damaged cartilage than smooth cartilage from the same patient. In chondrocytes, HS6ST2 could be targeted by miR-23b-3p, which was higher expressed in OA-damaged cartilage. Under TNF-α stimulation, the expression of HS6ST2 was found inversely correlated with the expression of miR-23b-3p. Downregulation of HS6ST2 regulated by overexpression of miR-23b-3p and siRNAs against HS6ST2 could enhance the protein level of MMP13 and aggravate the matrix degradation in chondrocytes. Increased expression of MMP13 depended on activity of p38 MAPK rather than total p38 MAPK level and was abrogated by HS6ST2 overexpression. Together, the results indicated that downregulated HS6ST2 targeted by miR-23b-3p promotes matrix degradation by activating p38 MAPK in chondrocytes and OA cartilage.
Scalable training of artificial neural networks with adaptive sparse connectivity inspired by network science
Authors: Mocanu Decebal Constantin , Mocanu Elena , Stone Peter , Nguyen Phuong H. , Gibescu Madeleine , Liotta Antonio 
Published: June 2018

AbstractThrough the success of deep learning in various domains, artificial neural networks are currently among the most used artificial intelligence methods. Taking inspiration from the network properties of biological neural networks (e.g. sparsity, scale-freeness), we argue that (contrary to general practice) artificial neural networks, too, should not have fully-connected layers. Here we propose sparse evolutionary training of artificial neural networks, an algorithm which evolves an initial sparse topology (Erdős–Rényi random graph) of two consecutive layers of neurons into a scale-free topology, during learning. Our method replaces artificial neural networks fully-connected layers with sparse ones before training, reducing quadratically the number of parameters, with no decrease in accuracy. We demonstrate our claims on restricted Boltzmann machines, multi-layer perceptrons, and convolutional neural networks for unsupervised and supervised learning on 15 datasets. Our approach has the potential to enable artificial neural networks to scale up beyond what is currently possible.
Carbon costs and benefits of Indonesian rainforest conversion to plantations
Authors: Guillaume Thomas , Kotowska Martyna M. , Hertel Dietrich , Knohl Alexander , Krashevska Valentyna , Murtilaksono Kukuh , Scheu Stefan , Kuzyakov Yakov 
Published: June 2018

AbstractLand-use intensification in the tropics plays an important role in meeting global demand for agricultural commodities but generates high environmental costs. Here, we synthesize the impacts of rainforest conversion to tree plantations of increasing management intensity on carbon stocks and dynamics. Rainforests in Sumatra converted to jungle rubber, rubber, and oil palm monocultures lost 116 Mg C ha−1, 159 Mg C ha−1, and 174 Mg C ha−1, respectively. Up to 21% of these carbon losses originated from belowground pools, where soil organic matter still decreases a decade after conversion. Oil palm cultivation leads to the highest carbon losses but it is the most efficient land use, providing the lowest ratio between ecosystem carbon storage loss or net primary production (NPP) decrease and yield. The imbalanced sharing of NPP between short-term human needs and maintenance of long-term ecosystem functions could compromise the ability of plantations to provide ecosystem services regulating climate, soil fertility, water, and nutrient cycles.
Dispositional free riders do not free ride on punishment
Authors: Weber Till O. , Weisel Ori , Gächter Simon 
Published: June 2018

AbstractStrong reciprocity explains prosocial cooperation by the presence of individuals who incur costs to help those who helped them (‘strong positive reciprocity’) and to punish those who wronged them (‘strong negative reciprocity’). Theories of social preferences predict that in contrast to ‘strong reciprocators’, self-regarding people cooperate and punish only if there are sufficient future benefits. Here, we test this prediction in a two-stage design. First, participants are classified according to their disposition towards strong positive reciprocity as either dispositional conditional cooperators (DCC) or dispositional free riders (DFR). Participants then play a one-shot public goods game, either with or without punishment. As expected, DFR cooperate only when punishment is possible, whereas DCC cooperate without punishment. Surprisingly, dispositions towards strong positive reciprocity are unrelated to strong negative reciprocity: punishment by DCC and DFR is practically identical. The ‘burden of cooperation’ is thus carried by a larger set of individuals than previously assumed.
Optimization of the structural characteristics of CaO and its effective stabilization yield high-capacity CO2 sorbents
Authors: Naeem Muhammad Awais , Armutlulu Andac , Imtiaz Qasim , Donat Felix , Schäublin Robin , Kierzkowska Agnieszka , Müller Christoph R. 
Published: June 2018

AbstractCalcium looping, a CO2 capture technique, may offer a mid-term if not near-term solution to mitigate climate change, triggered by the yet increasing anthropogenic CO2 emissions. A key requirement for the economic operation of calcium looping is the availability of highly effective CaO-based CO2 sorbents. Here we report a facile synthesis route that yields hollow, MgO-stabilized, CaO microspheres featuring highly porous multishelled morphologies. As a thermal stabilizer, MgO minimized the sintering-induced decay of the sorbents’ CO2 capacity and ensured a stable CO2 uptake over multiple operation cycles. Detailed electron microscopy-based analyses confirm a compositional homogeneity which is identified, together with the characteristics of its porous structure, as an essential feature to yield a high-performance sorbent. After 30 cycles of repeated CO2 capture and sorbent regeneration, the best performing material requires as little as 11 wt.% MgO for structural stabilization and exceeds the CO2 uptake of the limestone-derived reference material by ~500%.
Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
Authors: Mao Kai , Quipildor Gabriela Farias , Tabrizian Tahmineh , Novaj Ardijana , Guan Fangxia , Walters Ryan O. , Delahaye Fabien , Hubbard Gene B. , Ikeno Yuji , Ejima Keisuke , Li Peng , Allison David B. , Salimi-Moosavi Hossein , Beltran Pedro J. , Cohen Pinchas , Barzilai Nir , Huffman Derek M. 
Published: June 2018

AbstractDiminished growth factor signaling improves longevity in laboratory models, while a reduction in the somatotropic axis is favorably linked to human aging and longevity. Given the conserved role of this pathway on lifespan, therapeutic strategies, such as insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibodies (mAb), represent a promising translational tool to target human aging. To this end, we performed a preclinical study in 18-mo-old male and female mice treated with vehicle or an IGF-1R mAb (L2-Cmu, Amgen Inc), and determined effects on aging outcomes. Here we show that L2-Cmu preferentially improves female healthspan and increases median lifespan by 9% (P = 0.03) in females, along with a reduction in neoplasms and inflammation (P ≤ 0.05). Thus, consistent with other models, targeting IGF-1R signaling appears to be most beneficial to females. Importantly, these effects could be achieved at advanced ages, suggesting that IGF-1R mAbs could represent a promising therapeutic candidate to delay aging.
Out-of-equilibrium microcompartments for the bottom-up integration of metabolic functions
Authors: Beneyton Thomas , Krafft Dorothee , Bednarz Claudia , Kleineberg Christin , Woelfer Christian , Ivanov Ivan , Vidaković-Koch Tanja , Sundmacher Kai , Baret Jean-Christophe 
Published: June 2018

AbstractSelf-sustained metabolic pathways in microcompartments are the corner-stone for living systems. From a technological viewpoint, such pathways are a mandatory prerequisite for the reliable design of artificial cells functioning out-of-equilibrium. Here we develop a microfluidic platform for the miniaturization and analysis of metabolic pathways in man-made microcompartments formed of water-in-oil droplets. In a modular approach, we integrate in the microcompartments a nicotinamide adenine dinucleotide (NAD)-dependent enzymatic reaction and a NAD-regeneration module as a minimal metabolism. We show that the microcompartments sustain a metabolically active state until the substrate is fully consumed. Reversibly, the external addition of the substrate reboots the metabolic activity of the microcompartments back to an active state. We therefore control the metabolic state of thousands of independent monodisperse microcompartments, a step of relevance for the construction of large populations of metabolically active artificial cells.
Electron–electron interactions and the paired-to-nematic quantum phase transition in the second Landau level
Authors: Schreiber K. A. , Samkharadze N. , Gardner G. C. , Lyanda-Geller Y. , Manfra M. J. , Pfeiffer L. N. , West K. W. , Csáthy G. A. 
Published: June 2018

AbstractIn spite of its ubiquity in strongly correlated systems, the competition of paired and nematic ground states remains poorly understood. Recently such a competition was reported in the two-dimensional electron gas at filling factor ν = 5/2. At this filling factor a pressure-induced quantum phase transition was observed from the paired fractional quantum Hall state to the quantum Hall nematic. Here we show that the pressure-induced paired-to-nematic transition also develops at ν = 7/2, demonstrating therefore this transition in both spin branches of the second orbital Landau level. However, we find that pressure is not the only parameter controlling this transition. Indeed, ground states consistent with those observed under pressure also develop in a sample measured at ambient pressure, but in which the electron–electron interaction was tuned close to its value at the quantum critical point. Our experiments suggest that electron–electron interactions play a critical role in driving the paired-to-nematic transition.