bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic significance of Cep55 in oral squamous cell carcinoma
Authors: Surendra L , Haragannavar Vanishri C , Rao Roopa S , Prasad Kavitha , Sowmya SV , Augustine Dominic , Nambiar Shwetha 
Published: June 2018

Objective: Currently, oral squamous cell carcinoma (OSCC) is one of the most fatal cancers of all head and neck malignancies. Despite advancements in therapy, the mortality and morbidity remain high. Hence, it is essential to identify useful prognostic markers for high-risk individuals with OSCC to decide on treatment protocols. Centrosomal protein 55 ( Cep55), a regulator of the cell cycle, has been considered to play a role in carcinogenesis. Although there are numerous studies on its role in various other epithelial cancers such as breast, ovarian and lung cancers, its significance in the behaviour of OSCC is yet to be studied. The present study aimed to study Cep55 expression in OSCC and correlate with the tumour characteristics and patient survival. Materials and Methods: Forty pathologically diagnosed cases of OSCC were included in the study: 20 each of early and advanced OSCC cases. Formalin-fixed paraffin-embedded archival samples were used. The sections were immunohistochemically stained with Cep55 antibody. The expression levels of Cep55 were correlated with clinical parameters and disease outcome. Results: A higher expression of Cep55 was observed in advanced stage compared to early stage of OSCC. The Cep55 expression showed no significant relation with respect to clinical staging, pathological grading and site, except for tongue. Cep55 overexpression is significantly associated with poor survival. Conclusion: The present study suggests that Cep55 could play an important role in determining the biological behaviour and survival of OSCC patients independent of tumour staging and pathological grading. Thus, assessment of Cep55 expression could navigate the surgeons to plan an appropriate treatment.
Application of chlorite thermometry to estimation of formation temperature and redox conditions
Authors: Inoue Atsuyuki , Inoué Sayako , Utada Minoru 
Published: June 2018

ABSTRACTDiverse applications of chlorite thermometry have been considered for better understanding the formation process in nature. Here, an approach which combined a semi-empirical thermometer (Inoueet al.,2009) with the method of Walshe (1986) was tested to estimate the redox conditions (logfO2) and the formation temperature, using the literature data from Niger, Rouez and St Martin and new data for chlorite which coexists with pink-coloured epidote in the Noboribetsu geothermal field. The logfO2predicted for the former data sets were compatible with those estimated by Vidalet al.(2016), suggesting that the present approach is valid for quantifying the variations in logfO2. The Noboribetsu chlorites have lower Fe/(Fe + Mn + Mg) and greater Fe3+/ΣFe ratios than those observed in adjacent propylite rocks. The peculiar mineral assemblage and chemical composition are attributed to the formation under higherfO2conditions and possibly low Fe concentration in the alteration fluids.
Nonviral RNA chimeric antigen receptor–modified T cells in patients with Hodgkin lymphoma
Authors: Svoboda Jakub , Rheingold Susan R. , Gill Saar I. , Grupp Stephan A. , Lacey Simon F. , Kulikovskaya Irina , Suhoski Megan M. , Melenhorst J. Joseph , Loudon Brandon , Mato Anthony R. , Nasta Sunita Dwivedy , Landsburg Daniel J. , Youngman Matthew R. , Levine Bruce L. , Porter David L. , June Carl H. , Schuster Stephen J. 
Published: June 2018

Key Points
Manufacturing CART19 by transfecting autologous T cells with messenger RNA is feasible. Targeting CD19+ B cells in cHL using nonviral RNA CART19 was well tolerated and resulted in transient responses in a pilot study.
Development of the infant foot as a load bearing structure: study protocol for a longitudinal evaluation (the Small Steps study)
Authors: Price Carina , McClymont Juliet , Hashmi Farina , Morrison Stewart C. , Nester Christopher 
Published: June 2018

AbstractBackgroundAn improved understanding of the structural and functional development of the paediatric foot is fundamental to a strong theoretical framework for health professionals and scientists. An infant's transition from sitting, through crawling and cruising, to walking is when the structures and function of the foot must adapt to bearing load. The adaptation of skin and other hard and soft tissue, and foot and gait biomechanics, during this time is poorly understood. This is because data characterising the foot tissue and loading pre‐walking onset does not exist. Of the existing kinematic and plantar pressure data, few studies have collected data which reflects the real‐life activities of infants with modern equipment.MethodsThis is a longitudinal study and part of the Great Foundations Initiative, a collaborative project between the University of Brighton and the University of Salford, which is seeking to improve foot health in children. Two cohorts of 50 infants will be recruited at the two sites (University of Brighton, Eastbourne, UK and University of Salford, Salford, UK). Infants will be recruited when they first reach for their feet and attend four laboratory visits at milestones related to foot loading, with experienced independent walking being the final milestone. Data collection will include tissue characteristics (skin thickness, texture, elasticity, pH and tendon thickness and cross‐sectional area), plantar pressures and kinematics captured during real world locomotion tasks.DiscussionThis study will provide a database characterising the development of the infant foot as it becomes a weight bearing structure. The data will allow effective comparison and quantification of changes in structure and function due to maturation and loading by measuring pre and post established walking. Additional variables which impact on the development of the foot (gender, ethnicity and body weight) will also be factored into our analysis. This will help us to advance understanding of the determinants of foot development in early childhood.
A Dose-Escalating Study With the Fetal Estrogen Estetrol in Healthy Men
Authors: Coelingh Bennink Herjan J T , Zimmerman Yvette , Verhoeven Carole , Dutman Alice E , Mensinga Tjeert , Kluft Cornelis , Reisman Yacov , Debruyne Frans M J 
Published: June 2018

Abstract

Context
Luteinizing hormone–releasing hormone (LHRH) agonists have replaced estrogens for endocrine treatment of advanced prostate cancer (PC) because of cardiovascular side effects. The fetal estrogen estetrol (E4) may be safer for PC treatment and is expected to decrease testosterone (T) and prevent estrogen deficiency.

Objective
To investigate the safety and T-suppressive effect of E4 in healthy men.

Design
Double-blind, randomized, placebo-controlled, dose-escalating study.

Setting
The study was conducted at a phase I clinical unit (QPS, Netherlands).

Participants
Healthy male volunteers aged 40 to 70 years.

Intervention(s)
Three treatment cohorts of 15 volunteers with placebo (n = 5) and E4 (n = 10). Estetrol doses tested were 20, 40, and 60 mg/d. Subjects were treated for 4 weeks.

Main Outcome Measures
Subjective side effects, pharmacodynamic effects on hemostatic variables, lipids, glucose, bone parameters, and endocrine parameters related to T metabolism.

Results
Total and free T decreased dose-dependently and significantly. Nipple tenderness occurred in 40% and decrease of libido occurred in 30% of E4-treated men. The unwanted estrogenic effects on hemostasis were small, dose dependent, and in some cases significant. Lipid and bone parameters showed a favorable trend.

Conclusion
The effect of E4 on testosterone levels is insufficient for standalone PC treatment. Taking all clinical and pharmacodynamic variables into consideration, a daily dose of 40 mg E4 seems safe for further evaluation of endocrine PC treatment in combination with LHRH analogs.
Robert Duncan and the 1960s
Authors: Katz Daniel 
Published: June 2018

Abstract
This essay examines the contradictions of Robert Duncan’s 1960s political poetry by way of his reading of the legacy of modernism, notably as expounded in The H.D. Book. Drawing on the work of Daniel Tiffany, the essay first argues that here Duncan constructs a kitsch Ezra Pound to restore the true progressive political potential of Pound’s poetry. Using a largely Freudian methodology, Duncan finds in “kitsch” Pound a vector that opposes his authoritarian fascism. The essay then examines how Poundian poetics operates in Duncan’s poetry written in opposition to the Vietnam War and in support of the Berkeley free speech movement. This work is brought into dialogue with some of the conversations in France following May 1968 and with the slogan “Structures don’t take to the streets.” In both these sites, the question of the problematic relationship between individual political volition and activism, on the one hand, and a bourgeois conception of subjectivity, consciousness, and will, on the other, emerges as crucial.
Seeing Environmental Violence in Deep Time
Authors: Irvine Richard D. G. 
Published: June 2018

AbstractWhat does it mean to do violence in deep time? How is deep time evoked in our understanding of environmental harm? Environmental transformations have figured prominently in the recent history of Mongolia. Shifts in land use have been associated with severe pasture degradation, and the precarity of herding livelihoods has been a factor accelerating urbanization. Most recently, the intensification of mining activity has been a particular source of social and economic change. These contexts have led to a political and religious reevaluation of human relationships with the land. This article focuses on literary and musical interventions (particularly rap music in the first part of the article and the literary work of G. Mend-Ooyo in the later part) that draw attention to this changing relationship with the environment, which the article portrays as a potential rupture. We explore how these works domesticate deep time, nesting personal histories within the temporal depth of the landscape and crosshatching biographical, mythological, and geologic understandings of time. Yet we then see how this domestication comes to be threatened by developments that sever the relationship between people and land, leading to the disturbing prospect of being left stranded in the face of an inhospitable deep time.
Moderate Exercise Enhances Endothelial Progenitor Cell Exosomes Release and Function
Authors: MA CHUNLIAN , WANG JINJU , LIU HUA , CHEN YANYU , MA XIAOTANG , CHEN SHUZHEN , CHEN YANFANG , BIHL JI , YANG YI 
Published: June 2018

ABSTRACT

Purpose
Exercise has cardiovascular benefits which might be related to endothelial progenitor cells (EPC). Meanwhile, there is evidence suggesting that EPC-derived exosomes (EPC-EX) promote vascular repair and angiogenesis through their carried microRNA (miR)-126. In this study, we investigated whether exercise could increase the levels of circulating EPC-EX and their miR-126 cargo, and by which promote the protective function of EPC-EX on endothelial cells (EC).

Methods
Plasma EPC-EX from sedentary, low, or moderate exercise mice, respectively, denoted as EPC-EXS, EPC-EXL, and EPC-EXM, were isolated using microbead-based sorting techniques and characterized by nanoparticle tracking analysis, Western blot, and quantitative real-time polymerase chain reaction assessments of biomarkers and miR-126. High glucose (25 mM) with hypoxia (1% O2) was used for inducing an EC injury model. The injured EC were treated by coculturing with vehicle, EPC-EXS, EPC-EXL, EPC-EXM, or EPC-EXM + anti–miR-126. After that, EC were used for flow cytometry analysis of apoptosis, assessments of tube formation and migration, and measurements of miR-126 level and its downstream sprouty-related protein-1 (SPRED1) and vascular endothelial growth factor (VEGF).

Results
1) Isolated EPC-EX positively expressed exosomal markers (CD63 and Tsg101) and EPC markers (CD34 and VEGFR2). 2) Exercise intensity dependently elevated plasma level of EPC, EPC-EX/EPC ratio, and miR-126 expression in EPC and EPC-EX. 3) Injured EC displayed apoptosis increment, angiogenic dysfunction and miR-126 reduction. 4) EPC-EXM had better effects than EPC-EXS and EPC-EXL on alleviating those changes of injured EC, accompanied with SPRED1 downregulation and VEGF upregulation. 5) The effects of EPC-EXM were abolished by miR-126 knockdown.

Conclusions
Our data demonstrate that exercise can increase EPC-EX release and miR-126 level and enhance the effects of EPC-EX on protecting EC against injury through the SPRED1/VEGF pathway.
Adjunctive dexamethasone for the treatment of HIV-infected adults with tuberculous meningitis (ACT HIV): Study protocol for a randomised controlled trial
Authors: Donovan Joseph , Phu Nguyen Hoan , Mai Nguyen Thi Hoang , Dung Le Tien , Imran Darma , Burhan Erlina , Ngoc Lam Hong Bao , Bang Nguyen Duc , Giang Do Chau , Ha Dang Thi Minh , Day Jeremy , Thao Le Thi Phuong , Thuong Nguyen TT , Vien Nguyen Nang , Geskus Ronald B. , Wolbers Marcel , Hamers Raph L , van Crevel Reinout , Nursaya Mugi , Maharani Kartika , Hien Tran Tinh , Baird Kevin , Lan Nguyen Huu , Kestelyn Evelyne , Chau Nguyen Van Vinh , Thwaites Guy E. 
Published: June 2018

Background: Tuberculous meningitis (TBM) is the most severe form of tuberculosis. Co-infection with HIV increases the risk of developing TBM, complicates treatment, and substantially worsens outcome. Whether corticosteroids confer a survival benefit in HIV-infected patients with TBM remains uncertain. Hepatitis is the most common drug-induced serious adverse event associated with anti-tuberculosis treatment, occurring in 20% of HIV-infected patients. The suggested concentration thresholds for stopping anti-tuberculosis drugs are not evidence-based. This study aims to determine whether dexamethasone is a safe and effective addition to the first 6-8 weeks of anti-tuberculosis treatment of TBM in patients with HIV, and investigate alternative management strategies in a subset of patients who develop drug induced liver injury (DILI) that will enable the safe continuation of rifampicin and isoniazid therapy. Methods: We will perform a parallel group, randomised (1:1), double blind, placebo-controlled multi-centre Phase III trial, comparing the effect of dexamethasone versus placebo on overall survival in HIV-infected patients with TBM, in addition to standard anti-tuberculosis and antiretroviral treatment. The trial will be set in two hospitals in Ho Chi Minh City, Vietnam, and two hospitals in Jakarta, Indonesia. The trial will enrol 520 HIV-infected adults. An ancillary study will perform a randomised comparison of three DILI management strategies with the aim of demonstrating which strategy results in the least interruption in rifampicin and isoniazid treatment. An identical ancillary study will also be performed in the linked randomised controlled trial of dexamethasone in HIV-uninfected adults with TBM stratified by LTA4H genotype (LAST ACT). Discussion: Whether corticosteroids confer a survival benefit in HIV-infected patients remains uncertain, and the current evidence base for using corticosteroids in this context is limited. Interruptions in anti-tuberculosis chemotherapy is a risk factor for death from TBM. Alternative management strategies in DILI may allow the safe continuation of rifampicin and isoniazid therapy.
Reaching a consensus on research priorities for supporting women with autoimmune rheumatic diseases during pre-conception, pregnancy and early parenting: A Nominal Group Technique exercise with lay and professional stakeholders
Authors: Phillips Rhiannon , Williams Denitza , Bowen Daniel , Morris Delyth , Grant Aimee , Pell Bethan , Sanders Julia , Taylor Ann , Choy Ernest , Edwards Adrian 
Published: June 2018

Background:Women with autoimmune rheumatic diseases (ARDs) find it difficult to get information and support with family planning, pregnancy, and early parenting. A systematic approach to prioritising research is required to accelerate development and evaluation of interventions to meet the complex needs of this population. Methods:A Nominal Group Technique (NGT) exercise was carried out with lay and professional stakeholders (n=29). Stakeholders were prepared for debate through presentation of available evidence. Stakeholders completed three tasks to develop, individually rank, and reach consensus on research priorities: Task 1 – mapping challenges and services using visual timelines; Task 2 - identifying research topics; Task 3 - individually ranking research topics in priority order. Results of the ranking exercise were fed back to the group for comment. Results:The main themes emerging from Task 1 were the need for provision of information, multi-disciplinary care, and social and peer support. In Task 2, 15 research topics and 58 sub-topics were identified around addressing the challenges and gaps in care identified during Task 1. In Task 3, a consensus was reached on the ten research topics that should be given the highest priority. These were individually ranked, resulting in the following order of priorities (from 1 – highest to 10 – lowest): 1. Shared decision-making early in the care pathway; 2. Pre-conception counseling; 3. Information about medication use during pregnancy/breastfeeding; 4. Personalised care planning; 5. Support for partners/family members; 6. Information about local support/disease specific issues; 7. Shared decision-making across the care pathway; 8. Peer-support; 9. Social inequalities in care, and; 10. Guidance on holistic/alternative therapies. Conclusions:This systematic approach to identification of research priorities from a multi-disciplinary and lay perspective indicated that activities should focus on development and evaluation of interventions that increase patient involvement in clinical decision-making, multi-disciplinary models of care, and timely provision of information.
El activismo de la sociedad civil por la educación inclusiva en el campo judicial. Un estudio de caso
Authors: Arcidiácono Pilar , Barrera Leticia 
Published: June 2018

Alan Rodríguez es un joven con Síndrome de Down que al finalizar la escuela secundaria en una escuela común de la Ciudad de Buenos Aires, y habiendo aprobado todas las materias, no recibió su título secundario. En su reemplazo, obtuvo un certificado no oficial de graduado que no acredita la “terminalidad” de sus estudios. Esta situación motivó que Alan y su familia promovieran una demanda judicial contra la escuela y el Gobierno de la Ciudad de Buenos Aires (GCBA) con el objeto de que se le hiciera entrega de su título oficial en igualdad de condiciones que a sus pares.Desde el análisis de esta causa en un contexto de activismo de la sociedad civil, el artículo aborda la educación inclusiva de las personas con discapacidad como un campo de tensiones y disputas entre diferentes actores sociales (sus prácticas, saberes, narrativas, y moralidades). Estos conflictos ponen en entredicho el enfoque social inclusivo de la discapacidad que articulan tratados, normas constitucionales y algunas leyes nacionales, dando curso a prácticas que desarrollan la inclusión educativa en un marco de incertidumbre y ambigüedad.
A reflexão-ação como eixo da formação do professor: relato de experiência em uma faculdade bilíngue de pedagogia
Authors: Xavier Aline , Torres Maria Carmen Euller 
Published: June 2018

Este artigo é um relato de experiência de duas professoras e de estudantes do Departamento de Ensino Superior do Instituto Nacional de Educação de Surdos (DESU/INES) realizada em 2015, por ocasião das disciplinas ministradas no 5º período do curso de pedagogia desta Instituição. As disciplinas “Textos e pretextos” e “Cognição, corporeidade e contexto” tinham como objetivo comum refletir sobre práticas cotidianas desenvolvidas com crianças surdas da Educação Infantil e primeiros anos do Ensino Fundamental, no que tange à leitura e formação do leitor e à importância do brincar para o desenvolvimento infantil. As disciplinas se propuseram a oportunizar aos estudantes a vivência e a reflexão da prática educacional, trabalhando com conhecimentos teórico-práticos. Partimos do princípio de que a ação e a reflexão compõem uma relação dialógica e dialética. Como proposta de avalição dos cursos, foi lançado aos estudantes o desafio de confeccionarem brinquedos, produtos literários e outros materiais pedagógicos voltados às crianças surdas e posterior atuação junto a elas no colégio de aplicação do próprio INES. Queríamos, com isso, aproximar os estudantes do seu público–alvo e abrir um diálogo com educadores, coordenadores e crianças do Departamento de Ensino Básico do INES (DEBASI). O resultado deste projeto, além da sessão de contação de histórias e brincadeiras realizadas na sala de leitura do Setor de Ensino Fundamental 1 (SEF1), foi a compreensão de que o professor deve se instrumentalizar para observar, questionar e redimensionar seu cotidiano por meio de um diálogo permanente entre a teoria e a prática.
Literatura Surda e Contemporaneidade: contribuições para o estudo da Visual Vernacular
Authors: Ramos Danielle Cristina Mendes Pereira , Abrahão Bruno 
Published: June 2018

Este artigo tem como objetivo refletir sobre aspectos específicos da categoria da literatura surda chamada Visual Vernacular. Nossa proposta é a de estudar as suas especificidades e compreender os seus modos de organização estética. Além disso, intentamos pensá-la no âmbito de sua inserção no cenário cultural e artístico da contemporaneidade, pois acreditamos na necessidade de refletir sobre as manifestações literárias concernentes às expressões culturais surdas e às línguas de sinais em uma perspectiva ampla, que não a restrinja à mera leitura impressionista, mas que a considere dentro de um contexto pós-moderno de produção e de circulação cultural no qual ela ocupa um lugar, para além da dimensão solipsista. Para tanto, três conceitos contribuirão para o nosso esteio teórico: a noção de Contemporaneidade, a partir da proposta de Terry Smith (2013), que a percebe em uma dimensão plural, política e em construção; a percepção da inespecificidade da forma artística contemporânea, postulada por Florência Garramuño (2014), que nos ajudará a pensar sobre a experimentação estética pertinente à literatura surda, em sua dimensão tridimensional e performática; e a visão de hibridismo cultural proposta por Néstor Garcia Canclini (2006), que rechaça a possibilidade de pureza cultural e a contrapõe à presença da labilidade das fronteiras culturais e do deslocamento dos bens simbólico na pós-modernidade.
UBUNTU: ACOLHIMENTO ANCESTRAL E INQUIETAÇÕES FEMINISTAS NEGRAS À EDUCAÇÃO DE BEBÊS E CRIANÇAS PEQUENAS EM CRECHES E PRÉ-ESCOLAS
Authors: Oriel Pereira Artur , Santiago Flavio , Lima Souza Ellen Gonzaga 
Published: June 2018

O feminismo negro no Brasil vem conquistando espaços tanto no âmbito acadêmico quanto social, promovendo debates, releituras e autocríticas aos retrocessos no campo dos direitos sociais, ao mesmo tempo em que busca desarmar as estruturas eurocêntricas de representação do povo negro, descolonizando a iconografia pejorativa em torno da sua ancestralidade historicamente marcada pela sociedade racista, hetero-patriarcal, misógina e capitalista. Assim, este artigo procura discutir as infâncias e as relações raciais e de gênero no espaço da educação infantil, pressupondo que esse é um lugar de escuta, de diversas linguagens, bem como de valorização de saberes produzidos para além da colonialidade. Trata-se de uma pesquisa construída na intersecção entre os aportes africanos e afro-brasileiros, pensamento feminista negro e a perspectiva ubuntu que tem como foco o coletivo, buscando a ampliação das nossas percepções a respeito da sororidade e da educação dos bebês e das crianças pequenas, com vistas à construção de uma pedagogia da infância descolonizadora.