bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect Of Vitamin D Administration On Interleukin 6 (IL-6) Levels In Peritoneal Fluid In Endometrioma Patients
Authors: Setyasworo Singgeh , Mochtar Arufiadi Anityo , Erwinanto Erwinanto , Kristanto Herman , Tjahjanto Hary , Trisetiyono Yuli 
Published: December 2024

BACKGROUND: An endometrioma is a cyst that occurs when endometrial tissue grows on the epithelium of the ovary. Vitamin D is a steroid hormone that can be extracted from commonly available foods and can be synthesized by humans when exposed to sunlight. Vitamin D deficiency has been reported to be associated with various pathologies, including endometrioma. Vitamin D has been reported to have anti-angiogenic effects that may inhibit the growth of endometriotic implants.

AIM: Proving the effect of vitamin D administration on interleukin 6 (IL-6) levels in peritoneal fluid in patients with endometrioma.
METHOD: Experimental research with two group, post-test only design with single blind that carried out at Central General Hospital (RSUP) Dr. Kariadi Semarang. The research subject was 50 patients with endometrioma on ovary. The definite diagnosis of endometrioma is made based on histopathological examination of tissue samples after the patient undergoes surgery. Patients will be divided into 2 groups, namely the vitamin D3 supplementation group and placebo. The intervention was carried out by providing vitamin D3 50,000 IU/week for a month. Evaluation of serum vitamin D levels were obtained using venous blood samples immediately when the patient was undergoing surgery. Interlukin-6 levels were obtained using peritoneal fluid samples obtained when the patient underwent surgery. Statistical analysis was carried out using the Independent T Test, Mann-Whitney U, Dependent T Test and Wilcoxon. Results are significant if p <0.05. Statistical analysis was carried out using SPSS edition 26.
RESULT: Peritoneal fluid interleukin-6 (IL-6) levels between the vitamin D supplementation group and the placebo group did not show a significant difference (p=0.554).
CONCLUSION: Vitamin D supplementation in endometrioma patients is not associated with peritoneal fluid interleukin-6 (IL-6) levels.
Effects of α-Mangostin-Loaded Self-Nanoemulsion (MG-SNE) and Physical Exercise on The Reduction of Waist Circumference in Wistar Rats
Authors: Setiawan Andreas Arie , Sugiri Sugiri , Prasetyo Awal , Kurniawan Eirin Yovita , Putra Dominikus Evano 
Published: December 2024

BACKGROUND : Waist circumference (WC) is a marker of intra-abdominal adipose tissue and a risk factor for cardiometabolic disease. A higher risk of coronary heart disease was associated with an increased WC. Garcinia mangostana Linn's anti-inflammatory activity would reduce abdominal fat deposition and WC. Additionally, Garcinia mangostana Linn's potential would increase in nanotechnology.
AIMS : To demonstrate that WC in Wistar rats induced by an atherogenic diet can be decreased by α-Mangostin-loaded self-nanoemulsion (MG-SNE) treatment combined with physical activity.
METHOD : Experimental research with Randomized Control Trial design using a total sample of 15 male white rats (Rattus novergicus strain Wistar) weighing 300 grams and aged between 6 and 8 weeks, split into 3 groups given physical exercise for 8 weeks along with 3 different doses of medication (group K received Atorvastatin 1.44 mg once; group P1 received Garcinia mangostana Linn pericarp extract, at a dose of 800 mg/kg, divided into 3 administrations; and group P2 received MG-SNE 50 mg/kg once). Waist circumference was measured using a metline, before and after treatment.
RESULT : WC decreased in Groups K, P1, and P2, with deltas of -5.00±21.21 mm, -12.50±24.75 mm, and -17.50±12.58 mm. The greatest decrease in WC was P2. There was no significant difference, according to the paired test between the pre-test and posttest in all groups. The p value >0.05 was determined to indicate that there were no significant differences between the groups.
CONCLUSION : WC in Wistar rats induced by an atherogenic diet can be decreased by MG-SNE treatment combined with physical exercise.
Internalization Of At-Ta'lim, At-Tarbiyah, At-Ta'dib Values In ‎Forming Students' Morals
Authors: Oktavia Adinda , Syauqi Albaar‎ Akhmad , Sholikha‎ Wardatus , El-Yunusi Muhammad Yusron Maulana 
Published: December 2024

Lack of knowledge regarding students' morals towards teachers as teachers or as second parents in the school. The word "ta'lim" itself originates from the Arabic word and is an expression used to express education in ways including: 'Alamah, yu'allimu, and ta'lim". Ta'lim is defined as teaching, and yu'allimu is defined as teaching. Tarbiyah means "grow, increase, and height" in linguistics. In contrast, tarbiyah in sharia refers to charitable giving carried out through various channels and techniques that do not conflict with Islamic law. Ta'dib can be interpreted as how to educate or the process of educating, forming a person's morals and behavior according to the teachings of Islamic values ​​correctly and well. In the learning context, teachers are expected to be able to integrate these two concepts by providing good examples, guiding students in a loving way, and helping them become individuals who have good manners and in-depth knowledge. In this study, the author adopted a library research methodology because there are several consistent problems. a library research methodology because there are several consistent problems. Because there are at least several reasons underlying the author's use of the library research method. Firstly, the data source cannot be obtained from the field. Data sources in general can only be obtained through research or other written materials in the form of books, journals or other literature. The second is research or other written material in the form of books, journals or other literature. necessary as one of the few ways to understand a recent and difficult to understand phenomenon. Furthermore, using this study, the previously mentioned phenomena will be understood. Addressing emerging situations, the writer may formulate concepts to explain the emerging situation. Therefore, in responding to a situation that arises, the author can formulate a concept to explain the situation that arises. The third reason is that library data remains reliable for understanding researchers' problems. However, information or empirical data that has been collected by other people in the form of books, articles, or even research results can still be used, which can still be used by library researchers. Even in certain cases, field data is still not significant enough to answer the research questions to be carried out.
KESEJAHTERAAN PSIKOLOGIS PADA DEWASA AWAL DENGAN STATUS PENGANGGURAN
Authors: Salsa Bella Aryana  , Suwarti  
Published: December 2024

Ryff & Singer (2008) mendefinisikan kesejahteraan psikologi sebagai suatu realisasi atas pengembangan potensi pribadi secara utuh. Tujuan dalam studi penelitian ini yaitu untuk mengetahui bagaimana kesejahteraan psikologis pada dewasa awal dengan status sebagai seorang pengangguran. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kualitatif deskriptif. Teknik pengumpulan data dalam penelitian ini yaitu menggunkan teknik wawancara. Kriteria yang digunakan dalam penelitian ini yaitu: pria/wanita yang berstatus pengagguran dan berumur 18-27 tahun (Dewasa Awal). Hasil penelitian menyimpulkan bahwa subjek pertama dan subjek kedua memiliki kesejahteraan psikologis yang berbeda. Subjek pertama memiliki kesejahteraan psikologis yang kurang baik dan subjek kedua memiliki kesejahteraan psikologis yang baik.
Ryff & Singer (2008) define psychological well-being as the realization of the development of complete personal potential. The aim of this research study is to find out the psychological well-being of young adults with the status of being unemployed. The research method used in this research is a descriptive qualitative research method. The data collection technique in this research is using interview techniques. The criteria used in this research are: men/women who are unemployed and aged 18-27 years (Early Adult). The research results concluded that the first subject and the second subject had different psychological well-being. The first subject has poor psychological well-being and the second subject has good psychological well-being
BACTERIAL RESISTANCE TO CEFTRIAXONE IN DIFFERENT SPECIMENS AT GOVERNMENTAL HOSPITALS IN GAZA STRIP
Authors: Abu El Aish Khaled Ibrahim , Alkhodary Ahmed A , Helles Alaa , Moshtaha Ameed , Ghanem Sahar , Al Afifi Ahmed 
Published: December 2024

Ceftriaxone is one of the most prescribed antibiotics in hospitalized patients in Gaza. This study aimed to screen the antimicrobial resistance profile of ceftriaxone in the Gaza Strip (GS) in the State of Palestine. This study was cross-sectional, hospital-based, and was conducted in governmental hospitals across GS. The study started in November 2017 and continued till December 2018. Clinical samples such as pus, urine, sputum, blood, cerebrospinal fluid (CSF), and others were collected from hospitalized patients and outpatient clinics attendants. After identification of the bacterial isolates, a standard disc diffusion technique for drug susceptibility test was performed. Totally, 4397 bacterial isolates were obtained. Escherichia coli isolates were 38.3%, Klebsiella species were 16.4%, Pseudomonas species were 11.7%, and Staphylococcus aureus isolates were 11.5%. These mentioned organisms were the predominant organisms isolated from the study subjects. Additionally, 51.1% of the clinical isolates were found to be resistant to ceftriaxone. Also, 4.9% and 44.0% of the isolates remain intermediate and susceptible to ceftriaxone. E coli showed 50.0% (841/1683) resistance, while Klebsiella species showed 69.7% (502/720) resistance. Pseudomonas species showed 57.0% (294/516) resistance and S aureus showed 37.8% (191/505) resistance to ceftriaxone. Acinetobacter species showed 87.3% (96/110) resistance. Clinical isolates showed differences in their resistance to ceftriaxone during the study period, in different age categories, genders, and specimen types. The present study demonstrated an increase in the microbial resistance to ceftriaxone. It is very important to establish efficient strategies, updated prescribing guidelines and stewardship programs to preserve the efficiency of the antibiotics
Professor R.A. Melnikov — the path of a doctor and a scientist (on the 100th anniversary of his birth)
Authors: Правосудов Игорь Витальевич 
Published: December 2024

Рюрик Александрович Мельников — профессор, заслуженный деятель науки РСФСР, родился 12 ноября 1924 г. в г. Харькове. Всю практическую и научную деятельность проводил в стенах научно-исследовательского института онкологии им. Н.Н. Петрова. Рюрик Александрович Мельников проводил клинические исследования, которые охватили практически все локализации злокачественных опухолей человека. Результаты данных клинических исследований имеют огромную практическую значимость для здравоохранения и развития отечественной медицинской науки. Важным событием стал переезд Института Онкологии в поселок Песочный, после которого Рюрик Александрович возглавил отделение опухолей желудочно-кишечного тракта и руководил им почти 30 лет. Являясь широко известным специалистом-онкопроктологом, Р.А. Мельников во многом изменил подходы к лечению больных раком прямой кишки. Также Рюрик Александрович одним из первых в нашей стране начал разрабатывать проблему реабилитации онкологических больных. Рюрик Александрович Мельников навсегда останется в сердцах всех, как прекрасный человек, выдающийся ученый и талантливый хирург-онколог. Широкий диапазон его интересов, оригинальность научных изысканий позволяют говорить о несомненном таланте ученого, сделавшего много для развития отечественной медицинской науки.
Using Various Parameters of Tumor-Infiltrating Lymphocytes in Clinical Practice for Colorectal Cancer
Authors: Мнихович Максим Валерьевич , Ерофеева Людмила Михайловна , Борисов Денис Алексеевич , Тимофеев Роман Геннадиевич , Агафонова Юлия Сергеевна , Безуглова Татьяна Васильевна , Снегур Светлана Владимировна , Павлова Юлия Геннадиевна , Ширипенко Иван Александрович , Сарычева Анастасия Сергеевна 
Published: December 2024

Микроокружение опухоли в настоящее время рассматривается как биомаркер выживаемости онкологических больных и играет важную роль при выборе оптимальной противоопухолевой терапии. Понимание происходящих в опухолевом микроокружении процессов и взаимодействий динамично совершенствуется, что открывает новые возможности для практической и исследовательской деятельности. В настоящем обзоре представлены данные о различных подходах к изучению некоторых параметров опухоль-инфильтрирующих лимфоцитов и других компонентов микроокружения опухоли как биомаркера прогноза клинических исходов и как инструмента для назначения рациональной терапии при колоректальном раке. Для подготовки обзора проведен поиск литературы по базам данных Scopus, Web of Science, Medline, PubMed, CyberLeninka, РИНЦ и CNKI. При анализе использованы источники, индексируемые в базах данных Scopus, Web of Science, PubMed; 68 % работ опубликовано за последние 5 лет. Использовано 37 источников для написания данного литературного обзора.
Circulating DNA-Markers in Rectal Cancer Patients at the Stages of Combined Treatment and Dynamic Follow-up
Authors: Пономарева Анастасия Aлексеевна , Добродеев Алексей Юрьевич , Тарасова Анна Сергеевна , Афанасьев Сергей Геннадьевич , Костромицкий Дмитрий Николаевич , Паталяк Станислав Викторович , Чердынцева Надежда Викторовна , Рыкова Елена Юрьевна 
Published: December 2024

Введение. При выборе тактики лечения рака прямой кишки (РПК) большое внимание уделяется прогнозу и ранней диагностике рецидива заболевания. Известно, что злокачественная трансформация клеток сопровождается изменением профиля метилирования генома. При злокачественных новообразованиях в составе циркулирующей ДНК плазмы крови (цирДНК) и цирДНК, связанной с поверхностью клеток крови (скп-цирДНК), накапливаются фрагменты опухоль-ассоциированных ДНК, которые являются потенциальными онкомаркерами. Ранее было показано, что уровень метилирования ретроэлементов LINE-1 и генов SEPTIN9, IKZF1 изменяется в цирДНК плазмы крови больных колоректальным раком, по сравнению со здоровыми донорами.
Цель. Изучение изменения уровня метилирования генов SEPTIN9, IKZF1 и ретротранспозонов LINE-1 в цирДНК крови у больных РПК на этапах комбинированного лечения и динамического наблюдения с оценкой их прогностической значимости.
Материалы и методы. Образцы венозной крови были получены от 24 больных РПК до лечения, после предоперационной химиотерапии, через 10–15 дней после операции и далее каждые 3 мес. в рамках динамического наблюдения. Уровень метилирования выбранных маркеров определяли методом метил-специфической ПЦР в реальном времени.
Результаты. Уровень метилирования гена SEPTIN9 в скп-цирДНК после химиотерапии снижался в 1,7 раза, после резекции опухоли — в 2,3 раза, по сравнению с показателями до лечения. В свою очередь уровень метилирования гена IKZF1 в скп-цирДНК после комбинированного лечения снижался в 2 раза. Выявлено значимое увеличение уровня метилирования LINE-1 в скп-цирДНК в 1,6 раза после химиотерапии и в 3 раза после резекции опухоли, относительно исходных данных. В процессе динамического наблюдения у больных без рецидива РПК отмечалась стабилизация уровня метилирования всех маркеров. У больных с признаками прогрессирования данные маркеры показали повторные изменения, по сравнению с уровнем на 10–15-й день после операции.
Заключение. Полученные результаты свидетельствуют о перспективности определения исследованных аберрантно метилированных ДНК-маркеров для оценки эффективности терапии и раннего выявления рецидивов РПК.
Gastrointestinal Tract Tumors with Microsatellite Instability: A Single-Center Experience
Authors: Беляк Наталья Петровна , Орлова Рашида Вахидовна , Раскин Григорий Александрович , Кутукова Светлана Игоревна , Андросова Александра Валерьевна , Смирнова Наталья Валерьевна , Варанкина Анна Алексеевна , Наталенко Софья Александровна 
Published: December 2024

Введение. Развитие микросателлитной нестабильности в результате герминативной или спорадической мутации в генах системы репарации ошибочно спаренных нуклеотидов (MMR) является ключевым звеном в запуске механизмов канцерогенеза посредством формирования опухолевых неоантигенов, представляющих собой мишени для Т-лимфоцитов, что, в конечном счете, обусловливает высокую иммуногенность данных опухолей и их чувствительность к ингибиторам контрольных точек иммунитета.
Цель. Определение клинико-морфологических особенностей опухолей желудка, ободочной и прямой кишки с выявленной микросателлитной нестабильностью.
Материалы и методы. В ретроспективный анализ было включено 76 пациентов с установленным dMMR (36 пациентов больных колоректальным раком и 42 пациента со злокачественными новообразованиями желудка).
Результаты. Общими характеристиками для вышеописанных опухолей являются: местно-распространенный характер процесса (T3-T4, N2-N3), осложненное течение заболевания, превалирующее при иммуногистохимическом (ИГХ) тестировании выпадение белков РМS2, МLH1, прогрессирование и низкая частота достижения объективного ответа на фоне проводимой полихимиотерапией (ПХТ), высокая эффективность иммунотерапии (ИТ) в монорежиме или в комбинации с ПХТ (уровень контроля над заболеванием (65 % и 73,68 % для опухолей желудка и КРР соответственно)), медиана выживаемости без прогрессирования у пациентов, завершивших лечение ингибиторами контрольных точек, не достигнута как в группе рака желудка, так и в группе колоректального рака.
Strength of masonry made of ceramic brick with ground and unground surfaces (comparison of Russian and European norms)
Authors: Ponomarev O. I. , Mukhin M. A. , Chigrina O. S. , Dozorova A. Yu. , Smirnov S. I. 
Published: December 2024

Introduction. In recent years, much attention has been paid to the issues of reducing labor costs and increasing the reliability of test results of masonry ceramic wall products (brick, stone, and blocks). It is noted that when determining the masonry strength limit, the levelling of brick support surfaces is performed with mortar. However, when levelling the support surfaces by grinding, the masonry strength limit is artificially overestimated by at least one grade. In order to increase the reliability of erected buildings and structures, Note 1 to Table 6.1 of SP 15.13330.2020 “Masonry and reinforced masonry structures” gives an indication of the need to introduce appropriate correction factors in determining the strength of masonry. In the previous version of the SP, the values of reduction factors were adopted without appropriate justifications.Aim. To justify reduction of design compression resistance of masonry made of ceramic soft-mud brick (when determining its compressive strength with grinding of supporting surfaces) in order to increase the reliability of erected buildings and structures.Materials and methods. Comparison of normative and calculated values of the strength of masonry made of ceramic soft-mud brick on conventional mortar according to the norms of the Russian Federation, as well as Britain and Germany, on the basis of which the European norms have been developed.Results. The conducted comparison of British, German, and Russian norms showed that the calculated values of masonry strength given in the norms of European countries are lower than those in the norms of the Russian Federation due to higher safety factors.Conclusions. The decrease in the design compressive strength of masonry made of ceramic soft-mud brick by 10 % (when grinding the supporting surfaces to determine the compressive strength) is recognized as reasonable.
Visual working memory as the substrate for mental rotation: A replication
Authors: Ebert W. Miro , Jost Leonardo , Jansen Petra , Stevanovski Biljana , Voyer Daniel 
Published: December 2024

AbstractAn experimental study by Hyun and Luck suggests that object working memory, but not spatial working memory, is employed during mental rotation. In contrast, correlational research points to the relevance of spatial working memory in mental rotation. Considering these somewhat conflicting results and the fact that a small sample was acquired in the study of Hyun and Luck, a replication of their study was conducted. Additionally, potential sex effects were explored. We collected (usable) data from 213 individuals across two experiments. All participants performed a mental-rotation task alone, a working-memory task alone, and both tasks concurrently. We expected greater rotation-dependent interference between tasks when the working memory task concerned object features (Experiment 1) than when it concerned spatial locations (Experiment 2). In Experiment 1, dual-task interference was observed in working-memory accuracy. In Experiment 2, there were interference effects in both mental rotation accuracy and working-memory accuracy. However, interference did not differ between experiments. Moreover, interference was not rotation dependent in either of the experiments. Thus, we could not replicate the findings of Hyun and Luck. No sex differences were found in exploratory analyses. The general interference effects found in this study may reflect the involvement of visual working memory in the processing and decision-making stages of the mental rotation of letters. This study underscores the need for further research to fully understand the role of visual working memory in mental rotation, especially with more complex stimuli.
Efficiency and Precision in Printing: Study of the Control System of a Rotogravure Machine
Authors: Setiadi Rizki , Sumbodo Wirawan , Caesarendra Wahyu , Fitriyana Deni Fajar , Kriswanto Kriswanto , Bahatmaka Aldias 
Published: December 2024

Rotogravure printing is a well-liked and effective printing technique in the packaging sector of a printing cylinder. In making an automatic rotogravure machine, it is necessary to design an appropriate control system. In Indonesia, semi-automatic technology is still used to make rotogravure machines, and printing speeds are often slow. For automation machines, they are still imported. Apart from that, the machine's ability to adjust its precision is also limited. The purpose of this article is to examine the control system for a 6-cylinder automatic rotogravure machine, and discuss the rotogravure machine printing process, important aspects of rotogravure machine operation, differentiation in selecting motor types for torque and speed control, as well as advantages in efficiency and precision control over the environment. The method of using a literature review is qualitative-descriptive. The main findings on rotogravure machines include five main aspects: (1) ink flow management, (2) control of the drying system, (3) register control, (4) tension and speed control, and (5) fault detection, data logging, and analysis.
Contribution of Soret and Dufour aspects on Hybrid Nanofluid over 3D Magneto Radiative Stretching Surface with Chemical Reaction
Authors: Naga Lakshmi Bhavanam , Varanasi S Bhagavan , Ravuri Mohana Ramana , Ramana Reddy Gurrampati Venkata 
Published: December 2024

This study analyzes Soret and Dufour impacts on 3-dimensional, rotating HNF (CuO-Ag/Water) flow over a linearly stretchable surface that contains a mixture of Ag and CuO nanoparticles with H2O acting as the base fluid. Flow of governing PDEs is transformed into a system of ODEs, by using the bvp5c approach. Analysis and graphical presentation were made of the effect of the parameters included. The present study reveals that the Soret factor affects the surface's thermal efficiency whereas the Dufour impact lessens the surface mass transfer. The present work 99.9% compatible with previous work for stretching sheet parameter values are 0, 0.1, 0.2, 0.3, 0.4, 0.5. This conclusion may be employed in a variety of nanofluid cooling systems. This study may be used to inform future numerical and experimental studies.