bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer and apoptosis-inducing effects of curcumin against gall bladder carcinoma
Authors: Pandey Pratibha , Sayyed Uzma , Tiwari Rohit , Pathak Neelam , Siddiqui Mohammad Haris , Bajpai Preeti 
Published: March 2018

Curcumin, the primary bioactive component isolated from turmeric, has been shown to possess variety of biologic functions including anti-cancer activity. However, meticulous mechanism of the curcumin in gall bladder cancer has not been explored yet. Therefore, in our study, we elucidated the mechanism of the anticancer action of curcumin against human gall bladder cancer cells. It was found that the curcumin treated GBC cells decreased cell viability in a dose and time-dependent manner. Nuclear condensation, Annexin V-FITC/PI positive cells, and caspase-3 activation confirmed the apoptotic induction due to anti-proliferative action of curcumin. Furthermore, curcumin induced disruption in the mitochondrial membrane potential and increased reactive oxygen species generation which has not yet been reported in earlier studies of curcumin with gall bladder cancer. Moreover, curcumin-induced apoptosis of gall bladder cancer cells was also accompanied by significant amount of growth arrest at the G0/G1 phase of the cell cycle which has also not been documented previously. To the best part of my knowledge, this study has established curcumin as one of the promising chemotherapeutic agent against gall bladder carcinoma. Thus the present study explored a novel mechanism explaining the anti cancerous effects of curcumin, and may provide an alternative therapeutic approach which can overcome the side effects of chemotherapy.
Keywords: Gall bladder carcinoma Curcumin; Cell cycle analysis; Caspase-3; Apoptosis
Yohanes Bambang Mulyono, Sejarah dan Penafsiran Leksionaris Versi RCL, Jakarta: Grafika KreasIndo, 2014, xv+257 hlm.
Authors: Harun Martin 
Published: March 2018

Berulang kali saya ditanya oleh sesama umat Katolik apakah buku bacaan Misa Katolik juga dipakai oleh gereja Protestan, sebab mereka mengalami bahwa dalam ibadat hari minggu gereja Kristen lain dipakai bacaan Alkitab yang sama. Memang belum banyak diketahui perkem-bangan luar biasa yang selama setengah abad terakhir terjadi berkaitan dengan lectionarium atau leksionari ibadat hari Minggu dalam seluruh umat Kristen. Karena itu publikasi thesis Pendeta Y.B. Mulyono (S2 di STT Proklamasi) tentang Revised Common Lectionary (RCL) sangat di-butuhkan, dan membantu juga diri saya.
...
Thesis M. yang diterbitkan dengan rapi oleh Grafika KreasIndo (Sinode GKI) menjadi bacaan penting bagi setiap pengkhotbah, entah pendeta atau imam, dan hendaknya mendapat tempat dalam pendidikan hermeneutika dan homiletika para calon imam dan pendeta. (Martin Harun, Guru Besar Ilmu Teologi Emeritus, Sekolah Tinggi Filsafat Driyarkara, Jakarta).
Ham Madde Cinsi ve Üretim Parametrelerinin İplik Kalitesine Etkisi: Open-End İplikçiliği Üzerine Bir Uygulama
Authors: ERSOY Yusuf , ŞENOL Mahmut Fikri 
Published: March 2018

Bu
çalışmada, Sclafhorts-Saurer firması tarafından geliştirilmiş olan Autocoro 8
open-end rotor iplik makinesinde 18 farklı üretim parametresinde toplam 72 adet
test bobini üretimi gerçekleştirilmiştir.
İki farklı ham madde karışımından (% 80 pamuk-%20 polyester ve %91
pamuk-%9 polyester) üretilmiş olan ipliklerin tüylülük, ince yer, kalın yer,
neps ve düzgünsüzlük (% U) değerleri incelenmiştir. Elde edilen ölçüm
sonuçlarına SPPS 18 programında regresyon analizi uygulanmıştır. Bu çalışmada,
geri dönüşüm ham madde kullanılarak Autocoro 8 open-end rotor iplik makinesinde
yüksek devirlerde dahi kaliteli iplik üretilebildiği ve kullanılan ham madde
cinsi ve üretim parametrelerinin iplik kalitesini doğrudan etkilediği sonucuna
ulaşılmıştır.
Rekomendasi Pemupukan Kalium pada Budi Daya Cabai Merah Besar (Capscicum annuum L) di Inceptisols Dramaga
Authors: Sari Widyanti Amanda , D. Susila Anas 
Published: March 2018

ABSTRACTThe objective of this study was to determine the optimum rate of potassium fertilization in Inceptisols Dramaga. The experiment was conducted at Cikabayan University Farm from March to July 2014. This study was arranged in Randomized Complete Block Design one factor with five K fertilization rates, ie 0X (0 kg K2O ha-1), ¼ X (193.09 kg K2O ha-1), ½ X (386.19 kg K2O ha-1), ¾ X (579.29 kg K2O ha-1), and 1X (772.39 kg K2O ha-1). Potassium fertilizer was applied in three applications at 3, 6, and 9 weeks after transplanting. The results showed that K fertilization increased plant height, leaf number, weight per plant, fruit weight, fruit diameter, fruit length, marketable yield per plot, unmarketable yield per plot, marketable yield per hectare, and decrased unmarketable yield per hectare with linear response pattern. Addition of potassium did not affect the time of anthesis and fruit ripening. The addition of potassium fertilizer also increased total yield per plot and total yield per hectare with quadratic response pattern. In the medium K soil content with the value of 146.2 ppm (Morgan) K recommendation for red chili in inceptisols Dramaga was 487.5 kg K2O ha-1.Keywords: fertilizer, K2O, Morgan, optimum rate ABSTRAKPenelitian ini bertujuan memperoleh dosis optimum pemupukan kalium pada Inceptisols Dramaga. Penelitian dilaksanakan di unit lapangan Cikabayan University Farm mulai Maret sampai Juli 2014. Penelitian ini menggunakan Rancangan Kelompok Lengkap Teracak (RKLT) 1 faktor dengan lima perlakuan dosis pemupukan K, yaitu 0 X(0 kg K2O ha-1), ¼ X(193.09 kg K2O ha-1), ½ X(386.19 kg K2O ha-1), ¾ X(579.29 kg K2O ha-1), dan 1 X(772.39 kg K2O ha-1). Pupuk kalium diaplikasikan dalam tiga kali aplikasi pada 3, 6, dan 9 MST. Hasil penelitian menunjukkan bahwa pemupukan K meningkatkan tinggi tanaman, jumlah daun, bobot tanaman-1, bobot per buah, diameter buah, panjang buah, bobot layak per petak, bobot tidak layak per petak, bobot layak per hektar, dan mengurangi bobot tidak layak pasar per hektar dengan pola respon linear. Sementara itu penambahan kalium tidak berpengaruh terhadap waktu antesis dan waktu masak buah. Penambahan pupuk kalium juga meningkatkan hasil bobot panen total per petak dan panen total per hektar dengan pola respon kuadratik. Pada tingkat kelas ketersediaan K sedang dengan nilai terekstrak 146.2 ppm (Morgan) dihasilkan rekomendasi kalium untuk budi daya cabai merah besar di inceptisols Dramaga adalah 487.5 kg K2O ha-1.Kata kunci: dosis optimum, K2O, Morgan, pupuk
Efektivitas Pemberian IAA, IBA, NAA, dan Root-up pada Pembibitan Kesemek
Authors: Setiawan Eko 
Published: March 2018

ABSTRACTOriental persimmon (Diospyros kaki L.) originated from and has mainly been cultivated in China, Korea, and Japan, and currently it is cultivated in Batu, Kuningan, and Brastagi regions, Indonesia. Success in propagating persimmon in Indonesia has been limited. The objective of the study was to determine propagation techniques through root cutting supplemented with auxin treatment. All seedlings from root stock cutting supplemented with 100 ppm of either indoleacetic acid (IAA), indolebutyric acid (IBA), α-napthaleneacetic acid (NAA), or Root-up, and control. The results showed bud form stem or root cuttings treated with IAA, NAA and Root-up 100 ppm emerged earlier than IBA 100 ppm and control. The percentage of mortality of Root-up 100 ppm treatment and control cuttings was the highest (50%) than the others treatments. IAA and IBA treatments stimulated larger number of shoot, 16.5 and 17.0 shoots, respectively. The number of leaves was higher in plant treated with IAA 100 ppm (20.8 leaves). Keywords: auxin, Diospyros kaki L., germination, leaf number, root stock ABSTRAK Tanaman kesemek atau oriental persimmon (Diospyros kaki L.) banyak dibudidayakan di China, Korea, serta Jepang, dan saat ini banyak ditanam di Indonesia seperti di daerah Batu, Kuningan, dan Brastagi. Keberhasilan pembibitan kesemek di Indonesia masih rendah. Penelitian bertujuan untuk memperbanyak tanaman secara vegetatif dari pemisahan tunas akar dengan perlakuan auksin guna mendukung pengembangan pembibitan tanaman kesemek. Perbanyakan tanaman dilakukan dengan tunas akar yang direndam dengan auksin (IAA, IBA, NAA, dan Root-up; masing-masing 100 ppm), serta perlakuan kontrol. Hasil penelitian menunjukkan perlakuan IAA, NAA dan Root-up 100 ppm menghasilkan tunas lebih awal dibandingkan dengan kontrol dan IBA 100 ppm. Tingkat kematian bibit tertinggi mencapai 50% terjadi pada perlakuan Root-up 100 ppm dan kontrol. Jumlah tunas terbanyak dihasilkan oleh perlakuan IAA dan IBA sebanyak 16.5 dan 17.0 tunas. Jumlah daun terbanyak dihasilkan oleh perlakuan IAA 100 ppm (20.8 helai).Kata kunci: auksin, Diospyros kaki L., jumlah daun, muncul tunas, tunas akar
Computational analysis of 'Dose/Collision Kerma' relationship and lateral boundary in Stereotatic circular fields using EGSnrc.
Authors: Leão Reginaldo Gonçalves , Sousa Rômulo Verdolin de , Oliveira Arno Heeren de , Silva Hugo Lemos Leonardo , Mourão Arnaldo Prata 
Published: March 2018

Objectives: This work aimed to obtain data from small fields of X-rays that evidence of the hypotheses cited as cause of difficulties for the dosimetry of these. For this purpose, the verification of compatibility between the dosimetric boundary of field and the geometric size of field, was performed. Also was made, the verification of kerma dose according to the expected relationship for conventional fields. Materials and Methods: Computer simulations of smaller fields 5x5 cm² were performed using the Monte Carlo method by egs_chamber application, this derived from EGSnrc radiation transport code. As particulate sources were used phase space files of a Clinac 2100 head model coupled to cones Stereotactic Radiosurgery. Results: The simulations suggested the existence of a plateau in discrepancies between the dose FWHM and the nominal diameter of the field close to 8%. These simulations also indicated a decrease of these values for fields with diameters smaller than 12 mm and larger than 36 mm. Simultaneously, the dose kerma differences in depth reached values higher than 14% in the case where the phenomenon is more significant. Conclusion: The data showed that in fact the behavior of small fields clashes with that expected for conventional fields, and that the traditional dosimetric conventions do not apply to such fields requiring a specialized approach to the techniques that employ them. Furthermore, the existence of the aforementioned plateau of discrepancies, along with the decrease thereof in less than 15 mm diameter fields constitute a remarkable finding.
Elaboração e Implementação de Procedimentos Operacionais Padrão para Controle de Qualidade da Imagem CBCT em Radioterapia
Authors: Bonatto Larisse Neumann , Lopes Juliane Schossler , Sansson Angela , Estácio Daniela Da Rocha , Duarte Lucas Ost , Sbaraini Patricia , Marques da Silva Ana Maria , Streck Elaine Evani 
Published: March 2018

O objetivo deste artigo é apresentar a implementação do controle de qualidade da imagem de tomografia computadorizada por feixe cônico (CBCT), gerada pelo dispositivo On-Board Imager, integrado ao acelerador linear Trilogy. Para tal, foram elaborados procedimentos operacionais padrão (POP) com base na literatura e nos manuais do objeto simulador Catphan 504 e do On-Board Imager. Foram elaborados os seguintes POP: aquisição da imagem CBCT; linearidade do número de CT; uniformidade; resolução espacial; resolução de baixo contraste; linearidade espacial; espessura do corte. A validação dos procedimentos elaborados foi realizada a partir de uma aquisição experimental do objeto simulador. Os resultados obtidos na validação dos POP estão em conformidade com os parâmetros estabelecidos pelo fabricante do objeto simulador, assim como aqueles obtidos na aceitação do dispositivoOn-Board Imager.
Determinação da camada semirredutora e da tensão aplicada a partir de espectros emitidos por um tubo de raios X
Authors: Santos Josilene Cerqueira , Gonzales Alejandro Heyner Lopes , Terini Ricardo A , Costa Paulo Roberto 
Published: March 2018

Este trabalho descreve um método para o cálculo de camada semirredutora (CSR) e tensão de pico (kVp) aplicada ao tubo de raios X por meio de espectros medidos utilizando um detector de CdTe. São avaliados alguns parâmetros que podem influenciar na determinação dessas grandezas, tais como, tempo morto, taxa de contagens e valor de corrente anódica utilizado. Para isso, foram medidos dois conjuntos de espectros de raios X: Conjunto A, utilizando filtração de cobre de diferentes espessuras (1,8 - 5,4 mm) e mantendo fixa a corrente anódica aplicada ao tubo; Conjunto B, mantendo a filtração de cobre fixa e variando a corrente (0,5 - 3 mA). As configurações de medições dos espectros do conjunto A permitiram a avaliação da kVp e CSR para diferentes taxas de contagens e tempo morto do sistema de detecção, enquanto o conjunto B permitiu avaliar a dependência dessas grandezas com a corrente anódica do tubo. Fontes radioativas padrão foram usadas para fazer a calibração em energia do sistema espectrométrico. Os valores de tensão aplicados ao tubo foram determinados por meio de regressão linear a partir dos espectros medidos buscando o end point de cada um. Os valores de CSR foram determinados a partir dos espectros medidos, após sua correção por meio de um método de stripping implementado em ambiente Matlab®. Para comparação, a CSR também foi determinada usando uma câmara de ionização de 30 cm3 e filtros de Al de alta pureza. Os resultados mostram que é possível determinar a kVp com boa exatidão e reprodutibilidade, utilizando espectros com tempo morto de até 10%. Apesar disso, os valores obtidos apresentaram desvio de até 7 kV, para espectros medidos com mesma tensão nominal e diferentes valores de corrente, indicando a dependência entre esses dois parâmetros
Laboratory handling and rearing of early instar porina larvae from eggs
Authors: Atijegbe S.R. , Mansfield S. , Rostas M. , Ferguson C.M. , Worner S. 
Published: March 2018

Mass rearing Wiseana (porina) species, a major endemic insect pest in New Zealand pastures, has proved challenging for research and pest management and has presented problems over several decades in the laboratory. Researchers have acknowledged that handling the eggs and first instar larvae are of critical importance during laboratory rearing. A simple method is presented that improves survival of early instar porina larvae. Eggs of three porina species (W. cervinata, W. copularis, W. umbraculata) hatched faster at 22˚C than at 15˚C.
Determination of potential alternate hosts for violet root rot in Ohakune carrot fields
Authors: Hough E.G. , Horner I.J. , Horner M.B. 
Published: March 2018

Violet root rot (VRR), caused by the fungus Helicobasidium purpureum (anamorph Rhizoctonia crocorum), is a common problem for carrot growers in the Ohakune region of New Zealand. VRR can still be problematic even after many years of fallow, suggesting that alternative hosts may be maintaining and harbouring the disease. Seeds from a selection of common weed and pasture (ryegrass, clover and plantain) species sourced from the Ohakune area were planted into pots of steam-sterilised Ohakune soil and grown in the glasshouse. Following seedling establishment, pots were inoculated with H. purpureum.
Four and a half months post inoculation, all plants were assessed visually, and then well-rinsed root samples were taken for DNA extraction and PCR testing. Of the nine weed species assessed, all tested positive for H. purpureum by PCR, and seven had visual symptoms on plants. For the twelve pasture species assessed, ten tested positive for H. purpureum by PCR, while eight had visual symptoms on plants. Some plants, in particular various clovers, plantain and dock, had numerous sclerotia on the outside of roots. These results indicate that alternate hosts in pasture or fallowed fields are capable of harbouring H. purpureum.
Ассоциация полиморфизма гена <I>CYP3A5</I> с антигипертензивной эффективностью и переносимостью амлодипина у больных артериальной гипертензией I – II степени
Authors: Сычев Д. А. , Ших Надежда Валерьевна , Гришина Е. А. , Калле Е. Г. , Рыжикова К. А. , Морозова Т. Е. 
Published: March 2018

Проведено открытое несравнительное проспективное исследование с участием 100 больных артериальной гипертензией (АГ) I – II степени (мужчины — 45, женщины — 55) в возрасте от 45 до 58 лет (средний возраст (48,8 ± 8,31) лет). Исходное артериальное давление (АД) (147,80 ± 8,28/87,52 ± 7,52) мм рт. ст. Начальная доза амлодипина составила 5 мг, длительность приема 12 недель. В результате генотипирования по полиморфному маркеру A6986G выявлены следующие генотипы: генотип AG наблюдался у 9 больных, GG — у 91 больного, генотипа GA не выявлено. Отличная и хорошая антигипертензивная эффективность у больных с генотипом AG по полиморфному маркеру A6986G гена CYP3A5 (rs776746, *3) составила 78 %, GG — 60 % (p = 0,05). Увеличение дозы до 10 мг потребовалось 2 больным с генотипом AG (22 %) и 13 больным с генотипом GG (11 %) (p = 0,05). По данным офисного измерения АД снижение САД на фоне амлодипина составило у больных с генотипом AG (7,89 ± 3,39) мм рт. ст. (p = 0,05), GG (9,25 ± 3,16) мм рт. ст. (p = 0,05), ДАД (7,39 ± 3,18) мм рт. ст. (p = 0,06) и – (9,11 ± 4,08) мм рт. ст. (p = 0,02) соответственно. Достоверного изменения частоты сердечных сокращений не отмечено. У 4 из 9 больных с генотипом AG зафиксированы нежелательные побочные реакции преимущественно в виде отеков нижних конечностей, что в среднем составило 44 %; у больных с генотипом GG отмечено 10 случаев НПР, что в процентном соотношении составляет 11 % (достоверность межгрупповых различий AGvsGG p = 0,04). Таким образом, выявлена ассоциация между полиморфизмом гена CYP3A5 по полиморфному маркеру A6986g и суммарной антигипертензивной эффективностью и переносимостью амлодипина у больных АГ I – II степени.
MIKROKONTROLER AT MEGA 8535 SEBAGAI PENGENDALI INTENSITAS LAMPU PIJAR
Authors: Yufron Ahmad 
Published: March 2018

Perancangan sistem pengendalian intensitas lampu Pijar berbasis mikrokontroler ATmega8535. Jenis lampu yang dikendalikan intensitasnya adalah lampu pijar yang cenderung bersifat resistif. Pemrograman mikrokontroler untuk mengendalikan intensitas lampu Pijar menggunakan bahasa Basic dengan compiler dari Bascom AVR dan PonyProg2000 sebagai downloader ke mikrokontroler.
Assessment of Gonadal Function Following Single Dose of Radioiodine Therapy in Differentiated Thyroid Cancer Patients of Reproductive Age
Authors: Chowdhury Md Sunny Anam , Sultana Sadia , Awal Md Abdul , Sarmin Suraya , Salekin Mohammad Simoon 
Published: March 2018

<p><strong>Objective</strong>: This interventional study has undertaken to assess the gonadal function of differentiated thyroid cancer (DTC) patients within reproductive age group following single dose of radioactive iodine (131I) therapy/ablation.</p><p><strong>Patients and Methods:<em> </em></strong>A total of 69 patients (25 male and 44 female) of DTC were included in this study, those were referred for 131I ablation after total thyroidectomy. Following RAI, these patients were followed-up three times at three months interval. The usual I-131 dose was 75 or 100 m Ci for ablation of thyroid residues and 150 mCi for treatment of nodal metastasis. All the patients were interviewed about menstrual (female only) and reproductive history and investigated of the level of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone of male patients and FSH, LH, estradiol (E<sub>2</sub>) of female patients before administration of 131I and three, six and nine months after therapy.</p><p><strong>Result</strong>: In this study all of the 25 (100.0%) male patients showed high FSH level after three months of therapy. The mean± SD FSH level of male patients was found significantly (p-0.001) higher (15.59±7.53 IU/L) after three months of therapy than the pretherapy (4.85±2.57 IU/L) level. The mean± SD of FSH level was significantly declining in six months and nine months of follow up. The mean± SD of LH hormone level of these patients was found 6.1±3.67 IU/L in pretherapy which was significantly increased to 7.67±4.33 IU/L after three months. The mean LH level was 7.20±3.98 IU/L at six months follow up and 7.3±3.5IU/L after nine months. The differences of LH level between 3 months to 6 months and 6 months to 9 months are not statistically significant. No significant change was observed in testosterone level throughout the study period. In female, five patients developed irregular menstruation (changed duration of cycle or lighter amount), three patients developed amenorrhea associated with hot flashes within six months of 131I administration. Biochemical study of the patients with amenorrhoea showed markedly elevated serum FSH, LH level and declined E<sub>2 </sub>level. The FSH, LH levels of the two patients with amenorrhea became normal within study period and one patient had persistent amenorrhea at 9 months. E<sub>2</sub> level raised slowly.</p><p><strong>Conclusion</strong>: A single dose of radio-iodine (131I) therapy causes impairment of gonadal function of male patients within reproductive age group. In case of female patients the effect is insignificant. The effect is usually reversible and gonadal function of the patients restores within the study period.</p><p>Bangladesh J. Nuclear Med. 19(2): 92-97, July 2016 </p>
Evaluation of Carotid Intima-Media Thickness in Sub-clinical Hypothyroid Patients
Authors: Rahman Farhana , Haque Fatema Sultana , Biswas Shankar Kumar , Begum Rubina , Hossain Sadia , Sharmin Shaila , Rahman Mizanur , Hossain Sanowar , Nahar Kamrun 
Published: March 2018

<p><strong>Objective:</strong> Endothelial dysfunction and atherosclerosis may be associated with subclinical hypothyroidism (SCH) in multiple ways. The intima-media thickness of the common carotid artery (CIMT) is an important parameter for early atherosclerotic change. Previously several studies addressed the association between SCH and CIMT. Some studies indicate that SCH might be related to increase CIMT, while other studies revealed no significant association. The aim of the study was to further examine the relationship between CIMT and SCH patients in our own laboratory setting in Bangladesh.</p><p><strong>Patients and Methods: </strong>This cross sectional study was carried out at the Institute of Nuclear Medicine and Allied Sciences (INMAS), Dhaka Medical College Hospital Campus, Dhaka during the period of January 2016 to October 2016. The study included 56 consecutive patients. Out of 56 patients, 26 were in SCH group and 30 were in euthyroid control group. CIMT was measured in each subject via High resolution B-mode ultrasonography. Data were analyzed between these two groups in respect to age, sex, BMI, and mean CIMT.</p><p><strong>Results: </strong>Out of 56 subjects, 26 were SCH group and 30 were euthyroid control group. Male to female ratio was 3:23 and 9:21 in SCH and control groups respectively. The mean age was 30±7.4 and 32±8.7 years in SCH and control groups respectively. The mean BMI was 25.6±4.7 kg/m<sup>2</sup> in SCH and 25.1±4.1 kg/m<sup>2</sup> in control group. The mean CIMT was significantly (p≤0.05) higher in SCH group (Right-0.80±0.05 mm, Left-0.80±0.07 mm) than control group (Right-0.60±0.05 mm, Left- 0.61±0.05 mm). SCH group was further subdivided into two groups with a cut off value of serum TSH at 10 mIU/L. The mean CIMT was significantly higher in SCH with TSH above 10 mIU/L than SCH group with TSH less than 10 mIU/L (p≤0.05). Pearson’s rank correlation test showed significant positive correlation between both CIMT and TSH values.</p><p><strong>Conclusion: </strong>Our study showed that CIMT was significantly higher in SCH group than euthyroid control group. The CIMT values were positively correlated with the TSH values. Therefore we may conclude that SCH is an independent risk factor for atherosclerosis in addition to other classical risk factors.</p><p>Bangladesh J. Nuclear Med. 19(2): 123-127, July 2016</p>