bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishing an allied health professional delivered selective laser trabeculoplasty service in Scotland
Authors: Chadwick Oliver , Chia Seen Nee , Rotchford Alan 
Published: April 2019

AbstractPurposeTo describe the process of establishing a selective laser trabeculoplasty (SLT) service delivered by experienced allied health professionals (AHP) in a Scottish NHS Hospital Eye Service, and assess the safety and efficacy in comparison with SLT performed by ophthalmologists.MethodsA training scheme for AHPs who were experienced in extended roles within the glaucoma service was developed, consisting of supervised training by a consultant ophthalmologist specialising in glaucoma leading to the AHPs independently delivering SLT. A prospective audit of consecutive SLT procedures performed by AHPs between November 2015 and April 2017 was performed. Data were analysed and compared to a previous intradepartmental audit of SLT performed by ophthalmologists (consultants and trainees).ResultsA total of 325 eyes of 208 patients underwent SLT, of which 117 patients had bilateral SLT in a single session. The overall rate of complications was 3.9%, however these were minor and/or self‐limiting (this compared to a 3.8% complication rate in the ophthalmologist delivered SLT series). The rate of intraocular pressure (IOP) spike was 0.3%, compared to 1.4% in the ophthalmologist delivered SLT series. Mean IOP at listing was 20.9 ± 5.1 mmHg, 17.3 ± 4.5 mmHg at 3 months post SLT and 17.6 ± 3.7 mmHg at 12 months—a median reduction of 16.7% at 3 months and 17.4% at 12 months. There was no statistically significant difference between the percentage reduction in IOP in the AHP and ophthalmologist delivered SLT groups at 3 or 12 months.ConclusionsThis is the first service of its kind in Scotland and the outcomes of this study demonstrate that the AHP delivered SLT service is at least as safe as the previous ophthalmologist delivered SLT service. The data demonstrate a similar efficacy between AHP and ophthalmologist delivered SLT. In the face of increasing demand and workload, this is a practical model in service commissioning to free up medical clinicians for more complex glaucoma management.
Recombinant human C1 esterase inhibitor treatment for hereditary angioedema attacks in children
Authors: Reshef Avner , Grivcheva‐Panovska Vesna , Kessel Aharon , Kivity Shmuel , Klimaszewska‐Rembiasz Maria , Moldovan Dumitru , Farkas Henriette , Gutova Vaclava , Fritz Stephen , Relan Anurag , Giannetti Bruno , Magerl Markus 
Published: April 2019

AbstractBackgroundAttacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency (C1‐INH‐HAE) usually begin during childhood or adolescence. However, limited data are available regarding indications and modalities of treatment of children. This study evaluated recombinant human C1‐INH (rhC1‐INH) for HAE attacks in children.MethodsThis open‐label, phase 2 study included children aged 2‐13 years with C1‐INH‐HAE. Eligible HAE attacks were treated intravenously with rhC1‐INH 50 IU/kg body weight (maximum, 4200 IU). The primary end‐point was time to beginning of symptom relief (TOSR; ≥20 mm decrease from baseline in visual analog scale [VAS] score, persisting for two consecutive assessments); secondary end‐point was time to minimal symptoms (TTMS; <20 mm VAS score for all anatomic locations).ResultsTwenty children (aged 5‐14 years; 73 HAE attacks) were treated with rhC1‐INH. Seventy (95.9%) of the attacks were treated with a single dose of rhC1‐INH. Seven (35.0%) children were treated for four or more attacks. Overall, median TOSR was 60.0 minutes (95% confidence interval [CI], 60.0‐65.0); data were consistent across attacks. Median TTMS was 122.5 minutes (95% CI, 120.0‐126.0); data were consistent across attacks. No children withdrew from the study due to adverse events. No treatment‐related serious adverse events or hypersensitivity reactions were reported; no neutralizing antibodies were detected.ConclusionsRecombinant human C1‐INH was efficacious, safe, and well tolerated in children. Data support use of the same dosing regimen for HAE attacks in children (50 IU/kg; up to 4200 IU, followed by an additional dose, if needed) as is currently recommended for adolescents and adults.
Linear morphea overlying site of previous lichen aureus in a pediatric patient
Authors: Johnston Margaret , Benson Patrick , Morley Keith 
Published: April 2019

AbstractLichen aureus is a pigmented purpuric dermatosis that tends to occur on the lower extremities, and linear morphea is an inflammatory disease of the dermis and subcutaneous fat that leads to a scarlike induration. We present a pediatric case of linear morphea developing in the same anatomic distribution as prior lichen aureus. Due to the possible progression of lichen aureus to morphea described herein and the difficulty in diagnosing early morphea, close follow‐up may be considered for pediatric patients who present with this pigmented purpuric dermatosis.
Mineralogy and Geochemistry of Pyrite and Arsenopyrite from the Zaozigou Gold Deposit in West Qinling Orogenic Belt, Central China: Implications for Ore Genesis
Authors: Tang Qingyan , Di Pengfei , Yu Man , Bao Jian , Zhao Ying , Liu Dongxiao , Wang Yuxi 
Published: April 2019

AbstractThe Zaozigou gold deposit lies in the West Qinling orogenic belt, Gansu Province, China. It is one of the largest gold deposits, and the orebodies are hosted in fine‐grained slates intercalated with limestone of the Middle‐Triassic Gulangdi Formation and varied dykes. The gold orebodies are strictly controlled by the NE‐, NW‐, and SN‐trending tensional and shearing faults with high dipping angle. The mineralogy and geochemistry of pyrite and arsenopyrite are measured by electron microprobe. Pyrite has up to 0.12 wt.% Au, and arsenopyrite contains up to 0.17 wt.% Au. The antithetic correlation between S and As indicates the substitution of As for S in pyrite, and arsenic occurs in anionic As1− state in the pyrite structure under the reduced conditions. Pyrite has relatively high Co (~364–2248 ppm) but relatively low Ni (~109–497 ppm) contents, with Co/Ni ratios ranging from ~1.63 to 10.50, indicating that the deposit originated from a volcanogenic fluid and remobilized by hydrothermal fluid. Au in arsenopyrite occurs as cationic Au in solid solution, whereas Au in pyrite is in solid solution and metal nanoparticles (Au0). The texture characteristics and trace element geochemistry among cores, transition zones, and rims of pyrites demonstrate that there are at least four pulses of fluid participating in the generation of pyrite in the deposit. The calculated formation temperatures of the Zaozigou deposit vary from 148°C to 304°C, with an average temperature of 213°C based on Au contents in pyrite. The Pb isotopic compositions of pyrite samples suggest that the metallogenic materials of the Zaozigou deposit were derived from the mantle and upper crust. All the characteristics above lead us to draw the conclusion that the Zaozigou gold deposit is classified as an epithermal deposit.
Regulatory quality, financial integration and equity cost of capital
Authors: Nagaraj Priya , Zhang Chuanqian 
Published: April 2019

AbstractWe study the impact of international financial integration on firm‐level equity cost of capital in the presence of regulatory differences. International financial integration reduces the domestic cost of capital in the presence of well‐defined regulations that make it easier for foreign firms to overcome information asymmetry. We study this relationship for 55 countries for the period 2002 to 2014. Using multilevel mixed estimations, we find a negative relationship between cost of capital and both financial openness and regulatory quality. However, economies with better regulatory quality have a positive relationship between financial openness and cost of capital. Our results inform policy on the cost of higher level of regulations on firms’ equity cost of capital, especially when an economy has a high level of financial openness.
Inequality, leverage and crises: Theory and evidence revisited
Authors: Gu Xinhua , Tam Pui Sun , Zhang Yang , Lei Chun Kwok 
Published: April 2019

AbstractRajan points to rising income inequality as a root cause of the recent financial crisis through high household leverage. The Rajan hypothesis has ignited debate over the relationship between inequality, leverage and crises. Kumhof, Ranciere, and Winant prove the validity of this hypothesis with a theoretical formulation, but empirical studies provide mixed evidence using different samples and estimators. To clarify this controversy, we re‐examine the issue by using the same data as in the literature and provide additional evidence after taking into account the role of asset bubbles and policy interventions. Our regression is based on a new tractable theoretical model that is supported by key stylised facts, and all our analyses confirm the existence of the inequality–leverage–crisis nexus.
Peripheral artery endothelial function responses to altered shear stress patterns in humans
Authors: Cheng Jem L. , Au Jason S. , MacDonald Maureen J. 
Published: April 2019

New Findings
What is the central question of this study?
What is the effect of altered shear stress pattern, with or without concurrent neurohumoral and metabolic activation, on the acute endothelial function response assessed via brachial artery flow‐mediated dilatation?
What is the main finding and its importance?
Despite generating distinctive shear stress patterns (i.e. increases in anterograde only, anterograde only with neurohumoral and metabolic activation, and both anterograde and retrograde), similar acute improvements were observed in the brachial artery flow‐mediated dilatation response in all conditions, indicating that anterograde and/or turbulent shear stress might be the essential element to induce acute increases in endothelial function.
AbstractEndothelial function is influenced by both the direction and the magnitude of shear stress. Acute improvements in endothelial function have mostly been attributed to increased anterograde shear, whereas results from many interventional models in humans suggest that enhancing shear stress in an oscillatory manner (anterograde and retrograde) might be optimal. Here, we determined the acute brachial artery shear stress (SS) and flow‐mediated dilatation (FMD) responses to three shear‐altering interventions [passive heat stress (HEAT), mechanical forearm compression (CUFF) and handgrip exercise (HGEX)] and examined the relationship between changes in oscillatory shear index (OSI) and changes in FMD. During separate visits, 10 young healthy men (22 ± 3 years old) underwent 10 min of HEAT, CUFF or HGEX in their left forearm. Anterograde and retrograde SS, Reynolds number, OSI and FMD were assessed at rest and during/after each intervention. Anterograde SS increased during all interventions in a stepwise manner (P < 0.05 between interventions), with the change in HGEX (∆37.7 ± 12.2 dyn cm−2, P < 0.05) > CUFF (∆25.1 ± 11.9 dyn cm−2, P < 0.05) > HEAT (∆14.5 ± 7.9 dyn cm−2, P < 0.05). Retrograde SS increased during CUFF (∆−19.6 ± 4.3 dyn cm−2, P < 0.05). Anterograde blood flow was turbulent (i.e. Reynolds number ≥ |2000|) during all interventions (P < 0.05). The relative FMD improved after all interventions (P = 0.01), and there was no relationship between ∆OSI and ∆FMD. We elicited changes in SS profiles including increased anterograde SS (HEAT and HGEX) and both increased anterograde and retrograde SS (CUFF); regardless of the SS pattern, FMD improved to the same extent. These findings suggest that the presence of anterograde and/or turbulent SS might be the key to optimizing endothelial function in acute assessment protocols.
Receptor dependence of BDNF actions in superficial dorsal horn: relation to central sensitization and actions of macrophage colony stimulating factor 1
Authors: Boakye Paul A. , Rancic Vladimir , Whitlock Kerri H. , Simmons Danielle , Longo Frank M. , Ballanyi Klaus , Smith Peter A. 
Published: April 2019

Peripheral nerve injury elicits an enduring increase in the excitability of the spinal dorsal horn. This change, which contributes to the development of neuropathic pain, is a consequence of release and prolonged exposure of dorsal horn neurons to various neurotrophins and cytokines. We have shown in rats that nerve injury increases excitatory synaptic drive to excitatory neurons but decreases drive to inhibitory neurons. Both effects, which contribute to an increase in dorsal horn excitability, appear to be mediated by microglia-derived BDNF. We have used multiphoton Ca2+ imaging and whole cell recording of spontaneous excitatory postsynaptic currents in defined-medium organotypic cultures of GAD67-GFP+ mice spinal cord to determine the receptor dependence of these opposing actions of BDNF. In mice, as in rats, BDNF enhances excitatory transmission onto excitatory neurons. This is mediated via presynaptic TrkB and p75 neurotrophin receptors and exclusively by postsynaptic TrkB. By contrast with findings from rats, in mice BDNF does not decrease excitation of inhibitory neurons. The cytokine macrophage colony-stimulating factor 1 (CSF-1) has also been implicated in the onset of neuropathic pain. Nerve injury provokes its de novo synthesis in primary afferents, its release in spinal cord, and activation of microglia. We now show that CSF-1 increases excitatory drive to excitatory neurons via a BDNF-dependent mechanism and decreases excitatory drive to inhibitory neurons via BDNF-independent processes. Our findings complete missing steps in the cascade of events whereby peripheral nerve injury instigates increased dorsal horn excitability in the context of central sensitization and the onset of neuropathic pain. NEW & NOTEWORTHY Nerve injury provokes synthesis of macrophage colony-stimulating factor 1 (CSF-1) in primary afferents and its release in the dorsal horn. We show that CSF-1 increases excitatory drive to excitatory dorsal horn neurons via BDNF activation of postsynaptic TrkB and presynaptic TrkB and p75 neurotrophin receptors. CSF-1 decreases excitatory drive to inhibitory neurons via a BDNF-independent processes. This completes missing steps in understanding how peripheral injury instigates central sensitization and the onset of neuropathic pain.
Interactive Design of Random Aesthetic Abstract Textures by Composition Principles
Authors: Alvarez Luis , Monzón Nelson , Morel Jean-Michel 
Published: April 2019

Abstract
The automatic synthesis of abstract textures is, to some extent, feasible. As evidenced by abstract art theoreticians, one can think of an abstract picture as a tree of elementary shapes interacting according to a short list of compositional laws such as occlusion, exclusion and bordering, and by rendering rules such as transparency, tessellation and color selection. Randomizing the shape generator and the composition and rendering laws yields an algorithm generating random abstract textures. We have designed a user-friendly online tool that implements this algorithm.
Antimicrobial peptides in silkworm
Authors: Li Zhi , Ma Yan , Liu Xuan , Li Yi , Dai Fangyin 
Published: April 2019

Abstract
Antimicrobial peptides (AMPs) are a type of small molecular proteins that play a vital role in the resistance to alien pathogens. AMPs are widespread in bacteria, archaea, protists, fungi, plants and animals. AMPs have a broad spectrum of antimicrobial activities and they rarely induce bacteria resistance; thus, they are thought to be good candidates for antibiotics in clinical practice. Recently, AMPs are increasingly attracting attention because of their outstanding features and functions. In addition to their known antibacterial properties, some kinds of AMPs have also been reported to have antiviral, anticancer, antiparasitic, and antioxidant activity. In this review, we introduce the diversity of AMPs, including their structure, function and related mechanisms. We focus primarily on recent studies of silkworm AMPs and summarize their classification, activities and possible mechanisms. Finally, based on the review, probable directions and perspectives for studies of the AMPs of silkworm are discussed and proposed.
Carcinization in the Anomura - fact or fiction? I. Evidence from adult morphology
Authors: McLaughlin Patsy A. , Lemaitre Rafael 
Published: April 2019

Carcinization, or the process of becoming a crab, has been, and continues to be, a focal point of anomuran evolutionary hypotheses. Traditional examples of carcinization in the Anomura are most celebrated among hermit crabs but certainly are not limited to this group. Carcinization, if it has occurred, has done so independently in all major anomuran taxa.
In this critique, the traditional examples of carcinization in the Anomura are reviewed and more modern variations on the theme assessed. Potential pathways of carcinization are examined from perspectives of adult morphology in the Paguroidea, Galatheoidea, Hippoidea and Lomoidea, with emphasis on the Paguroidea. Specific attention is given to the theoretical transformation of a hermit crab-like body form into a “king crab”- like lithodid crab. Resulting coercive evidence indicates: (1) that while the evolution of a crab-like body form certainly occurs, the traditional applications, based on inadequate and often inaccurate data, are flawed; and (2) that lithodid crabs did not arise from a hermit crab predecessor through the process of carcinization.
The Changing Fates of the Cambodian Islamic Manuscript Tradition
Authors: Bruckmayr Philipp 
Published: April 2019

AbstractPredominantly Buddhist Cambodia is home to a distinctive Islamic manuscript tradition, introduced into the country by Cham settlers from Champa in present-day Vietnam, and further developed in the Khmer kingdom. Commonly written in Cham script (akhar srak) or in a combination of the latter and Arabic, it has largely fallen into disuse among the majority of Cambodian Muslims since the mid-19th century, as the community increasingly turned towards Islamic scholarship and printed books in jawi (i.e. Arabic-script-based) Malay. Among the side effects of this development was the adoption of jawi also for the Cham language, which has, however, only been employed in a modest number of manuscripts. A minority of akhar srak users and discontents of growing Malay religious and cultural influence, based mainly in central and northwestern Cambodia, have, however, kept the local Islamic manuscript tradition alive. Recognized by the Cambodian state as a distinct Islamic religious community in 1998, this group now known as the Islamic Community of Imam San, has made the physical preservation of, and engagement with, their manuscripts a central pillar of identity and community formation. The present article provides insight into the changing fates of the Islamic manuscript tradition in Cambodia as well as an overview of content, distribution and usage of Islamic manuscripts in the country.
A Mamluk Qurʾānic Ǧuzʾ and Its Connection with Amīr ʿAbd al-Qādir al-Ǧazāʾirī
Authors: Juvin Carine 
Published: April 2019

AbstractThis article presents a Mamluk Qurʾān ǧuzʾ copied in Cairo in the late 14th century, newly acquired by the Musée du Louvre. It is an interesting example of manuscript production in this period and well contextualized thanks to its informative colophon. It can be linked with other volumes of the same Qurʾān now in Cairo and Brussels. This manuscript was acquired together with some documents (two letters, a note and a watercolour) revealing information about its circulation in the 19th century and connecting it with the amīr ʿAbd al-Qādir al-Ǧazāʾirī and the French orientalist Léon Roches.
Arabic Manuscripts from Buton, Southeast Sulawesi, and the Literary Activities of Sultan Muḥammad ʿAydarūs (1824–1851)
Authors: Peacock A.C.S. 
Published: April 2019

AbstractThis article examines the Arabic manuscripts of Buton Island, Southeast Sulawesi, Indonesia, focussing on the Abdul Mulku Zahari collection. In particular, it studies manuscripts of texts composed by the ruler of Buton, Sultan Muḥammad ʿAydarūs (r. 1824–1851) who wrote a large number of Sufi works in both Arabic and Wolio, the literary language of the Butonese court. The manuscripts attest not only the religious and intellectual culture of the court, but also Buton’s connections with the wider Islamic world including the Hijaz and its reformist Sufi movements. The article also situates Muḥammad ʿAydarūs’s Arabic works in the broader context of Butonese history and textual production.
The Democratizing Effects of Transnational Actors’ Access to International Courts
Authors: Squatrito Theresa 
Published: April 2019

Abstract
Little attention has been given to understanding how international courts feature in legitimacy assessments. How should the performance of international courts be evaluated in terms of their effect on a democratic deficit in international lawmaking? This article takes an initial step toward understanding how international courts improve or weaken the presence of democratic values in international lawmaking. In particular, this article focuses on one aspect of international courts—access for transnational actors. This article argues that TNA access to international courts provides an institutional mechanism to advance participation and transparency in international lawmaking. Normative and empirical analysis are combined to illustrate the extent to which access applies to international courts. Based on the empirical findings, which show a marked increase in TNA access to international courts, I argue that the increased participation and transparency made available through TNA access have democratizing effects on international lawmaking.
Not Just Another Pint! The Role of Emotion Induced by Music on the Consumer’s Tasting Experience
Authors: Reinoso-Carvalho Felipe , Dakduk Silvana , Wagemans Johan , Spence Charles 
Published: April 2019

Abstract
We introduce a novel methodology to assess the influence of the emotion induced by listening to music on the consumer’s multisensory tasting experience. These crossmodal effects were analyzed when two contrasting music tracks (positive vs negative emotion) were presented to consumers while tasting beer. The results suggest that the emotional reactions triggered by the music influenced specific aspects of the multisensory tasting experience. Participants liked the beer more, and rated it as tasting sweeter, when listening to music associated with positive emotion. The same beer was rated as more bitter, with higher alcohol content, and as having more body, when the participants listened to music associated with negative emotion. Moreover, participants were willing to pay 7–8% more for the beer that was tasted while they listened to positive music. This novel methodology was subsequently replicated with two different styles of beer. These results are discussed along with practical implications concerning the way in which music can add significant value to how a consumer responds to a brand.