bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basal Serum Cortisol and Testosterone/Cortisol Ratio Are Related to Rate of Na+ Lost During Exercise in Elite Soccer Players
Authors: Castro-Sepulveda Mauricio , Cancino Jorge , Fernández-Verdejo Rodrigo , Pérez-Luco Cristian , Jannas-Vela Sebastian , Ramirez-Campillo Rodrigo , Del Coso Juan , Zbinden-Foncea Hermann 
Published: June 2019

During exercise, the human body maintains optimal body temperature through thermoregulatory sweating, which implies the loss of water, sodium (Na+), and other electrolytes. Sweat rate and sweat Na+ concentration show high interindividual variability, even in individuals exercising under similar conditions. Testosterone and cortisol may regulate sweat Na+ loss by modifying the expression/activity of the cystic fibrosis transmembrane conductance regulator. This has not been tested. As a first approximation, the authors aimed to determine whether basal serum concentrations of testosterone or cortisol, or the testosterone/cortisol ratio relate to sweat Na+ loss during exercise. A total of 22 male elite soccer players participated in the study. Testosterone and cortisol were measured in blood samples before exercise (basal). Sweat samples were collected during a training session, and sweat Na+ concentration was determined. The basal serum concentrations of testosterone and cortisol and their ratio were (mean [SD]) 13.6 (3.3) pg/ml, 228.9 (41.4) ng/ml, and 0.06 (0.02), respectively. During exercise, the rate of Na+ loss was related to cortisol (r = .43; p < .05) and to the testosterone/cortisol ratio (r = −.46; p < .01), independently of the sweating rate. The results suggest that cortisol and the testosterone/cortisol ratio may influence Na+ loss during exercise. It is unknown whether this regulation depends on the cystic fibrosis transmembrane conductance regulator.
Prognostic patterns and predictors in epilepsy: a multicentre study (PRO-LONG)
Authors: Beghi Ettore , Beretta Simone , Carone Davide , Zanchi Clara , Bianchi Elisa , Pirovano Marta , Trentini Claudia , Padovano Giada , Colombo Matteo , Cereda Diletta , Scanziani Sofia , Giussani Giorgia , Gasparini Sara , Bogliun Graziella , Ferrarese Carlo 
Published: June 2019

Objectives
To describe the long-term prognosis of epilepsy and prognostic patterns in a large cohort of newly diagnosed patients and identify prognostic factors.

Methods
Study participants were 13 Italian epilepsy centres with accessible records dating back to 2005 or earlier, complete data on seizure outcome and treatments, precise epilepsy diagnosis, and follow-up of at least 10 years. Records were examined by trained neurology residents for demographics, seizure characteristics, neurological signs, psychiatric comorbidity, first electroencephalogram (EEG) and MRI/CT, epilepsy type and aetiology, antiepileptic drugs (AEDs), and 1-year, 2-year, 5-year and 10-year seizure remissions. Five predefined prognostic patterns were identified: early remission, late remission, relapsing-remitting course, worsening course and no remission. Prognostic factors were assessed using multinomial logistic regression models.

Results
1006 children and adults were followed for 17 892 person-years (median 16 years; range 10–57). During follow-up, 923 patients (91.7%) experienced 1-year remission. 2-year, 5-year and 10-year remissions were present in 89.5%, 77.1% and 44.4% of cases. 5-year remission was associated with one to two seizures at diagnosis, generalised epilepsy, no psychiatric comorbidity, and treatment with one or two AEDs during follow-up. 10-year remission was associated with one or two AEDs. The most common prognostic pattern was relapsing-remitting (52.2%), followed by early remission (24.5%). 8.3% of cases experienced no remission. Predictors of a relapsing-remitting course were <6 seizures at diagnosis, (presumed) genetic aetiology and no psychiatric comorbidity.

Conclusions
Few seizures at diagnosis, generalised epilepsy and no psychiatric comorbidity predict early or late seizure freedom in epilepsy. Achieving remission at any time after the diagnosis does not exclude further relapses.
Methane emissions, feed intake, and total tract digestibility in lambs fed diets differing in fat content and fibre digestibility
Authors: McGeough E.J. , Passetti L.C.G. , Chung Y.H. , Beauchemin K.A. , McGinn S.M. , Harstad O.M. , Crow G. , McAllister T.A. 
Published: June 2019

This study determined enteric methane (CH4) emissions, intake, and apparent total tract digestibility of diets varying in fibre digestibility and fat content. A Latin square design with two levels of fat [2.0% and 6.0% dry matter (DM); low and high] and two levels of fibre digestibility [low fibre digestibility (LFbD) or high fibre digestibility (HFbD)] was used. Higher dry matter intake (DMI) was observed (P < 0.01) for LFbD versus HFbD diets (2.56 vs. 2.14 kg d−1, respectively), with no effect of fat. Fibre, DM, and organic matter digestibility were higher (P < 0.01) for HFbD than LFbD diets. Increasing fat did not affect intake or digestibility of DM or dietary constituents but there was a fibre digestibility × fat content interaction (P < 0.01) for fat digestibility. There was also a fat content × fibre digestibility interaction (P < 0.05) for CH4 (g kg−1 DMI, organic matter intake, neutral detergent fibre intake, and percent gross energy intake), with emissions being higher when fat was added to the HFbD than the LFbD diet. The CH4 emissions per kilogram of neutral detergent fibre (NDF) digested were higher (P < 0.01) for the HFbD than the LFbD diet. Methane emissions were increased by the HFbD diet, but inclusion of fat had a differential impact on CH4 emissions as a proportion of DMI or NDF intake in diets differing in fibre digestibility.
Will That Pulmonary Nodule Become Cancerous? A Risk Prediction Model for Incident Lung Cancer
Authors: Nemesure Barbara , Clouston Sean , Albano Denise , Kuperberg Stephen , Bilfinger Thomas V. 
Published: June 2019

AbstractThis prospective investigation derived a prediction model for identifying risk of incident lung cancer among patients with visible lung nodules identified on computed tomography (CT). Among 2,924 eligible patients referred for evaluation of a pulmonary nodule to the Stony Brook Lung Cancer Evaluation Center between January 1, 2002 and December 31, 2015, 171 developed incident lung cancer during the observation period. Cox proportional hazard models were used to model time until disease onset. The sample was randomly divided into discovery (n = 1,469) and replication (n = 1,455) samples. In the replication sample, concordance was computed to indicate predictive accuracy and risk scores were calculated using the linear predictions. Youden index was used to identify high-risk versus low-risk patients and cumulative lung cancer incidence was examined for high-risk and low-risk groups. Multivariable analyses identified a combination of clinical and radiologic predictors for incident lung cancer including ln-age, ln-pack-years smoking, a history of cancer, chronic obstructive pulmonary disease, and several radiologic markers including spiculation, ground glass opacity, and nodule size. The final model reliably detected patients who developed lung cancer in the replication sample (C = 0.86, sensitivity/specificity = 0.73/0.81). Cumulative incidence of lung cancer was elevated in high-risk versus low-risk groups [HR = 14.34; 95% confidence interval (CI), 8.17–25.18]. Quantification of reliable risk scores has high clinical utility, enabling physicians to better stratify treatment protocols to manage patient care. The final model is among the first tools developed to predict incident lung cancer in patients presenting with a concerning pulmonary nodule.
Cumulative Meta‐Analysis of the Soy Effect Over Time
Authors: Jenkins David J. A. , Blanco Mejia Sonia , Chiavaroli Laura , Viguiliouk Effie , Li Siying S. , Kendall Cyril W. C. , Vuksan Vladmir , Sievenpiper John L. 
Published: June 2019

Background
Soy protein foods have attracted attention as useful plant protein foods with mild cholesterol‐lowering effects that are suitable for inclusion in therapeutic diets. But on the basis of the lack of consistency in significant cholesterol reduction by soy in 46 randomized controlled trials, the US Food and Drug Administration (FDA) is reassessing whether the 1999 heart health claim for soy protein should be revoked.

Methods and Results

We have, therefore, performed a cumulative meta‐analysis on the 46 soy trials identified by the FDA to determine if at any time, since the 1999 FDA final rule that established the soy heart health claim, the soy effect on serum cholesterol lost significance. The cumulative meta‐analysis for both total cholesterol and low‐density lipoprotein cholesterol demonstrated preservation of the small, but significant, reductions seen both before and during the subsequent 14 years since the health claim was originally approved. For low‐density lipoprotein cholesterol, the mean reduction in 1999 was −6.3 mg/dL (95% CI, −8.7 to −3.9 mg/dL;
P
=0.00001) and remained in the range of −4.2 to −6.7 mg/dL (
P
=0.0006 to
P
=0.0002, respectively) in the years after 1999. At no time point did the total cholesterol or low‐density lipoprotein cholesterol reductions lose significance or were the differences at individual time points in the cumulative meta‐analysis significantly different from those seen in 1999 when the health claim was approved.

Conclusions
A cumulative meta‐analysis of the data selected by the FDA indicates continued significance of total cholesterol and low‐density lipoprotein cholesterol reduction after soy consumption and supports the rationale behind the original soy FDA heart health claim.
The Derodontidae, Dermestidae, Bostrichidae, and Anobiidae of the Maritime Provinces of Canada (Coleoptera: Bostrichiformia)
Authors: MAJKA CHRISTOPHER G. 
Published: June 2019

The beetle families of the Bostrichiformia—the Derodontidae, Dermestidae, Bostrichidae, and Anobiidae – in the Maritime Provinces of Canada are surveyed. Seventy-four native and established introduced species are now known to occur including 30 found in New Brunswick, 65 in Nova Scotia, and 29 on Prince Edward Island. Seven species are newly recorded from New Brunswick, 24 from Prince Edward Island, and 37 from Nova Scotia for a total of 68 new provincial records. A total of 31 species are newly recorded in the Maritime Provinces as a whole, three of which, Dinoderus minutus (Fabricius), Ernobius filicornis LeConte, and Ernobius granulatus LeConte, are newly recorded in Canada. Two species, Ptilinus pruinosus Casey and Caenocara oculata (Say), are removed from the faunal list of New Brunswick, and one subspecies, Attagenus unicolor unicolor (Brahm), is removed from the faunal list of Prince Edward Island since no specimens or published records could be found to support their presence. Additional records of six other exotic species intercepted at ports and points in the region, but not established here, are also reported. A specimen of the Palearctic Ptinus bicinctus Sturm collected in 1915 in Nova Scotia, establishes a new early timeline for this species in North America. The fauna of the region is distinguished by the very large proportion (37 of 74 species, i.e. 50%) of which is introduced. It is also distinguished by the large proportion (22 of 37 species, i.e. 60%) of the indigenous, native fauna that is apparently rare, perhaps as a result of the historical impact of forest management practices on these wood-boring, saproxylic species. The fauna is further evaluated from both zoogeographic and ecological perspectives.
The Meniscus midges of Costa Rica (Diptera: Dixidae)
Authors: CHAVERRI LUIS GUILLERMO , BORKENT ART 
Published: June 2019

A revision of the Dixidae of Costa Rica indicates that 10 named species of Dixella are present, eight of which are described as new (described stages indicated): D. fernandezae (%), D. hansoni (%), D. hernandezi (%), D. jironi (%), D. lobata (%, &), D. maculata (%, &), D. suzukii (%, &), D. woodi (%). Two named species were previously known from Costa Rica: D. shannoni Lane (%, &) and D. venezuelensis Lane (%, &). A key to the species of Costa Rica is provided and other similar Neotropical species discussed. An overview of all Central American species is given. Five of the 10 Costa Rican species were collected above 1200 meters in elevation, indicating that further collecting, especially at high elevations will reveal further species. Five additional species from Costa Rica remain unnamed because they are represented only by females. A total of 15 species of Dixella are therefore present in this country.
On a new Ercolania Trinchese, 1872 (Opisthobranchia, Sacoglossa, Limapontiidae) living within Boergesenia Feldmann, 1950 (Cladophorales), with notes on anatomy, histology and biology
Authors: GRZYMBOWSKI YVONNE , STEMMER KRISTINA , WÄGELE HEIKE 
Published: June 2019

A new sacoglossan species, belonging to the genus Ercolania Trinchese, 1872 is described. E. kencolesi sp. nov. has a similar biology as E. endophytophaga Jensen, 1999. Both are living within syncytial algal tubes of members of the Siphonocladales, E. kencolesi sp. nov. in Boergesenia forbesii and E. endophytophaga in Struvea plumosa. Assignment to the genus Ercolania is possible on the base of the cerata, which are round in cross-section, the digitiform rhinophores, sabot-shaped teeth and the presence of a penial stylet. The new species can be easily distinguished from E. endophyto-phaga, by the teeth with a prominent cusp, as well as other Ercolania species, by its unique colouration and its peculiar association to the food alga Boergesenia. Feeding, copulation, egg masses and development are noted. Differences in development further strengthen the distinction of E. kencolesi to E. endophytophaga. Measurement of photosynthetic activity of incorporated chloroplasts during several days clearly shows that chloroplasts are digested.
Developing a Department of Transportation Winter Severity Index
Authors: Walker Curtis L. , Steinkruger Dylan , Gholizadeh Pouya , Hasanzedah Sogand , Anderson Mark R. , Esmaeili Behzad 
Published: June 2019

AbstractAdverse weather conditions are responsible for millions of vehicular crashes, thousands of deaths, and billions of dollars per year in economic and congestion costs. Many transportation agencies utilize a performance or mobility metric to assess how well they maintain road access; however, there is only limited consideration of meteorological impacts to the success of their operations. This research develops the Nebraska winter severity index (NEWINS), which is a daily event-driven index derived for the Nebraska Department of Transportation (NDOT). The NEWINS includes a categorical storm classification framework to capture atmospheric conditions and possible road impacts across diverse spatial regions of Nebraska. A 10-yr (2006–16) winter season database of meteorological variables for Nebraska was obtained from the National Centers for Environmental Information. The NEWINS is based on a weighted linear combination applied to the collected storm classification database to measure severity. The NEWINS results were compared to other meteorological variables, many used in other agencies’ winter severity indices. This comparison verified the NEWINS robustness for the observed events for the 10-yr period. An assessment of the difference between days with observed snow versus days with accumulated snow revealed 39% fewer snow-accumulated days than snow-observed days. Furthermore, the NEWINS results highlighted the greater number of events during the 2009/10 winter season and the lack of events during the 2011/12 winter season. It is expected that the NEWINS could help transportation personnel allocate efficiently resources during adverse weather events. Moreover, the NEWINS framework can be used by other agencies to assess their weather sensitivity.
Decadal SST Variability in the Southeast Indian Ocean and Its Impact on Regional Climate
Authors: Li Yuanlong , Han Weiqing , Zhang Lei , Wang Fan 
Published: June 2019

Abstract
The southeast Indian Ocean (SEIO) exhibits decadal variability in sea surface temperature (SST) with amplitudes of ~0.2–0.3 K and covaries with the central Pacific (r = −0.63 with Niño-4 index for 1975–2010). In this study, the generation mechanisms of decadal SST variability are explored using an ocean general circulation model (OGCM), and its impact on atmosphere is evaluated using an atmospheric general circulation model (AGCM). OGCM experiments reveal that Pacific forcing through the Indonesian Throughflow explains &lt;20% of the total SST variability, and the contribution of local wind stress is also small. These wind-forced anomalies mainly occur near the Western Australian coast. The majority of SST variability is attributed to surface heat fluxes. The reduced upward turbulent heat flux (QT; latent plus sensible heat flux), owing to decreased wind speed and anomalous warm, moist air advection, is essential for the growth of warm SST anomalies (SSTAs). The warming causes reduction of low cloud cover that increases surface shortwave radiation (SWR) and further promotes the warming. However, the resultant high SST, along with the increased wind speed in the offshore area, enhances the upward QT and begins to cool the ocean. Warm SSTAs co-occur with cyclonic low-level wind anomalies in the SEIO and enhanced rainfall over Indonesia and northwest Australia. AGCM experiments suggest that although the tropical Pacific SST has strong effects on the SEIO region through atmospheric teleconnection, the cyclonic winds and increased rainfall are mainly caused by the SEIO warming through local air–sea interactions.
Brain age in bipolar disorders: Effects of lithium treatment
Authors: Van Gestel Holly , Franke Katja , Petite Joanne , Slaney Claire , Garnham Julie , Helmick Carl , Johnson Kyle , Uher Rudolf , Alda Martin , Hajek Tomas 
Published: June 2019

Objective: Bipolar disorders increase the risk of dementia and show biological and brain alterations, which resemble accelerated aging. Lithium may counter some of these processes and lower the risk of dementia. However, until now no study has specifically investigated the effects of Li on brain age. Methods: We acquired structural magnetic resonance imaging scans from 84 participants with bipolar disorders (41 with and 43 without Li treatment) and 45 controls. We used a machine learning model trained on an independent sample of 504 controls to estimate the individual brain ages of study participants, and calculated BrainAGE by subtracting chronological from the estimated brain age. Results: BrainAGE was significantly greater in non-Li relative to Li or control participants, F(2, 125) = 10.22, p < 0.001, with no differences between the Li treated and control groups. The estimated brain age was significantly higher than the chronological age in the non-Li (4.28 ± 6.33 years, matched t(42) = 4.43, p < 0.001), but not the Li-treated group (0.48 ± 7.60 years, not significant). Even Li-treated participants with partial prophylactic treatment response showed lower BrainAGE than the non-Li group, F(1, 64) = 4.80, p = 0.03. Conclusions: Bipolar disorders were associated with greater, whereas Li treatment with lower discrepancy between brain and chronological age. These findings support the neuroprotective effects of Li, which were sufficiently pronounced to affect a complex, multivariate measure of brain structure. The association between Li treatment and BrainAGE was independent of long-term thymoprophylactic response and thus may generalize beyond bipolar disorders, to neurodegenerative disorders.
Outcomes of gender-sensitivity educational interventions for healthcare providers: A systematic review
Authors: Lindsay Sally , Rezai Mana , Kolne Kendall , Osten Victoria 
Published: June 2019

Background: Although gender plays an important role in health, most healthcare providers lack knowledge in providing gender-sensitive care. Offering gender-sensitivity training for healthcare providers can help to address gender-based health inequalities. Method: A mixed-methods systematic review of gender-sensitivity training programmes or interventions for healthcare providers was undertaken to assess their outcomes and to document areas for future research. Comprehensive searches of seven international databases were conducted for peer-reviewed literature published between 1998 and 2018. Eligible studies included at least one outcome related to gender-sensitivity training for healthcare providers. Results: Twenty-nine studies met the inclusion criteria. Fourteen studies focused on gender-sensitivity in reducing gender bias towards men and women, and 15 studies focused on addressing the needs of lesbian, gay, bisexual and transgender (LGBT) patients. Thirty-seven percent of studies showed a significant improvement in gender-related knowledge, attitudes or practice after the training. Multiple training methods were used to teach gender-sensitive care. Common content of the training included learning sex/gender terminology, understanding gender issues and inequalities in health, stigma and discrimination and communication skills. The duration and frequency of interventions ranged considerably. Sex differences in training outcomes also occurred among the learners. Conclusion: Review findings highlight that although gender-sensitivity training for healthcare providers is increasing, there is insufficient evidence to determine its effectiveness. Additional, more rigorously designed studies are needed to assess the long-term implications on learner behaviours and practices, especially across a wide variety of healthcare providers.
Biomechanics of Long Cane Use
Authors: Wall Emerson Robert , Kim Dae Shik , Naghshineh Koorosh , Myers Kyle R. 
Published: June 2019

Introduction: The modern long cane has been used by people who are blind for traveling for decades. This article describes parameters surrounding the collection of over 10,000 trials of people walking with the long cane to detect drop-offs or obstacles. Methods: The data include 10,069 trials representing 101 different participants in 366 conditions over 11 studies spanning the 9 years from 2007 to 2016. Each of the studies investigated different participant or cane characteristics or both in terms of their effect on either drop-off or obstacle detection. Results of detection performance in these studies appear in other articles. This article describes biomechanical measures derived from 3-D motion analysis equipment used during the studies. Results: Initial treatment of the large data set indicated that participants tended to not center their cane arc laterally on their body, deviating up to about 20 centimeters from midline. Arc widths averaged almost a meter, and arcs were generally centered. Participants were generally poor at being in step or having consistent rhythm. Coverage rates averaged about 85%. Discussion: Although participants might have demonstrated artificially high skill performance due to being in a research study, data do offer insights into mechanical performance of skills. This survey of the data set indicates that not centering the hand holding the cane does not decrease body coverage less than about 85%. However, further analyses will be conducted to delve more deeply into all aspects of the data. Implications for practitioners: Basic cane skills can be taught with short sessions and massed practice. Novices can acquire basic cane skills on par with cane users who are blind, but individual differences exist and the interplay of biomechanical variables needs to more fully understood.