bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trial protocol for the validation of the‘Toronto Aortic Stenosis Quality of Life (TASQ) Questionnaire’ in patients undergoing surgical aortic valve replacement (SAVR) or transfemoral (TF) transcatheter aortic valve implantation (TAVI): the TASQ registry
Authors: Frank Derk , Kennon Simon , Bonaros Nikolaos , Romano Mauro , Lefèvre Thierry , Di Mario Carlo , Stefàno Pierluigi , Ribichini Flavio Luciano , Himbert Dominique , Urena-Alcazar Marina , Salgado-Fernandez Jorge , Cuenca Castillo Jose Joaquin , Garcia Bruno , Kurucova Jana , Thoenes Martin , Lüske Claudia , Bramlage Peter , Styra Rima 
Published: May 2019

BackgroundPatients with severe aortic stenosis (AS) have a reduced life expectancy and quality of life (QoL), owing to advanced age and the presence of multiple comorbidities. Currently, there is no AS-specific QoL measurement tool, which prevents an accurate assessment of how this chronic condition and its treatment affect patients. The Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ) was developed in order to address this deficiency.MethodsThe present trial protocol was designed to enable validation of the TASQ, which has been produced in five languages (English, French, German, Italian and Spanish) to increase usability. Patients with severe AS who are undergoing surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI) will be asked to complete the TASQ and, for comparative purposes, the Kansas City Cardiomyopathy Questionnaire and the general health-related QoL Short Form-12 questionnaire. The questionnaires will be completed prior to the intervention, at discharge, as well as at 30 days and 3 months follow-up. A total of 290 patients will be recruited across one Canadian and nine European centres. Overall, the protocol validation aims to include 120 patients undergoing transfemoral TAVI (TF-TAVI), 120 undergoing SAVR and up to 50 being treated medically. The primary objective of the registry is to validate the TASQ in five different languages. The secondary objective is to assess the utility of the TASQ for assessing differences in QoL outcome between patients undergoing TF-TAVI, SAVR or medical management for their AS.DiscussionValidation and roll-out of the TASQ will enable clinicians to capture an accurate assessment of how AS and its management affects the QoL of patients and will help them to determine the most appropriate treatment strategy for individual patients.Trial registration numberNCT03186339
A Multicenter, Randomized, Placebo-Controlled Study Evaluating the Efficacy of a Combination of Propolis and Cranberry (<b><i>Vaccinium macrocarpon</i></b>) (DUAB®) in Preventing Low Urinary Tract Infection Recurrence in Women Complaining of Recurrent Cystitis
Authors: Bruyère Franck , Azzouzi Abdel Rahmène , Lavigne Jean-Philippe , Droupy Stéphane , Coloby Patrick , Game Xavier , Karsenty Gilles , Issartel Bertrand , Ruffion Alain , Misrai Vincent , Sotto Albert , Allaert Francois-André 
Published: May 2019

<b><i>Objectives:</i></b> The purpose of the study was to compare the efficacy of a product containing cranberry and propolis (DUAB) to placebo for reducing frequency of cystitis in women with recurrent acute cystitis. <b><i>Method:</i></b> A multicenter, placebo-controlled, randomized study of women aged &#x3e;18 years with at least 4 episodes of cystitis in the previous 12 months was performed. The number of cystitis episodes over a 6-month follow-up was the primary end point. <b><i>Results:</i></b> Forty-two women were included in the cranberry + propolis group, and 43 women were in the placebo group. The mean age was 53 ± 18 years, with 6.2 ± 3.6 cystitis episodes in the previous year, with no differences between the 2 groups. The mean number of infections was lower in the propolis + cranberry group (respectively, 2.3 ± 1.8 vs. 3.1 ± 1.8). The total number of cystitis episodes in the first 3 months was lower in the propolis + cranberry group (0.7 ± 1.1 vs. 1.3 ± 1.1, <i>p</i> = 0.0257) after adjusting for water consumption. The mean time to onset of the first urinary tract infection (UTI) was also significantly longer in the propolis + cranberry group (69.9 ± 45.8 days vs. 43.3 ± 45.9, <i>p</i> = 0.0258). Tolerance to the treatments was good and comparable in both groups. <b><i>Conclusions:</i></b> We demonstrate for the first time that cranberry and propolis supplementation significantly reduces the incidence of UTIs during the first 3 months and delays the onset of an episode of cystitis.
Modulating the Baseline Impedance
Authors: Shapira-Daniels Ayelet , Barkagan Michael , Rottmann Markus , Sroubek Jakub , Tugal Derin , Carlozzi Michael A. , McConville James W. , Buxton Alfred E. , Anter Elad 
Published: May 2019

Background:
Radiofrequency ablation of intramural ventricular substrate is often limited by insufficient tissue penetration despite high energy settings. As lesion dimensions have a direct and negative relationship to impedance, reducing the baseline impedance may increase the ablation effect on deep ventricular tissue.

Methods:
This study included 16 patients with ventricular tachycardia or frequent ventricular premature complexes refractory to ablation with irrigated catheters. After a failed response to radiofrequency ablation, impedance was modulated by adding or repositioning return patches in an attempt to decrease the circuit impedance. Ablation was repeated at a similar location and power settings, and the effect on arrhythmia suppression and adverse effects were evaluated.

Results:

Six patients with idiopathic ventricular premature complexes originating from the left ventricular summit (n=4) or papillary muscles (n=2), 6 patients with noninfarct related ventricular tachycardia and 4 patients with infarct-related ventricular tachycardia had unsuccessful response to radiofrequency ablation at critical sites (number of applications: 10.4±3.1, power: 42.3±2.9 W, duration: 55.3±25.5 seconds, impedance reduction: 14.6±3.5 Ω, low-ionic solution was used in 81.25%). Modulating the return patches resulted in reduced baseline impedance (111.7±8.2 versus 134.7±6.6 Ω,
P
<0.0001), increased current output (0.6±0.02 versus 0.56±0.02 Amp;
P
<0.0001) and greater impedance drop (16.8±3.0 Ω,
P
<0.001). Repeat ablation at similar locations had a successful effect in 12 out of 16 (75.0%) patients. During a follow-up duration of 13±5 months, 10 out of 12 (83.3%) patients remained free of arrhythmia recurrence. The frequency of steam pops was similar between the higher and lower baseline impedance settings (7.1 versus 8.2%;
P
=0.74).

Conclusions:
In patients with deep ventricular substrate, reducing the baseline impedance is a simple, safe, and effective technique for increasing the effect of radiofrequency ablation. However, its combination with low-ionic solutions may increase the risk for steam pops and neurological events.
Blood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase
Authors: Prysyazhna Oleksandra , Wolhuter Kathryn , Switzer Christopher , Santos Celio , Yang Xiaoping , Lynham Steven , Shah Ajay M. , Eaton Philip , Burgoyne Joseph R. 
Published: May 2019

Background:
The health-promoting and disease-limiting abilities of resveratrol, a natural polyphenol, has led to considerable interest in understanding the mechanisms of its therapeutic actions. The polyphenolic rings of resveratrol enable it to react with and detoxify otherwise injurious oxidants. Whilst the protective actions of resveratrol are commonly ascribed to its antioxidant activity, here we show that this is a misconception.

Methods:
The ability of resveratrol to oxidize cGMP-dependent PKG1α (protein kinase 1α) was assessed in isolated rat aortic smooth muscle cells, and the mechanism of action of this polyphenol was characterized using in vitro experiments, mass spectrometry and electron paramagnetic resonance. The blood pressure of wild-type and C42S knock-in mice was assessed using implanted telemetry probes. Mice were made hypertensive by administration of angiotensin II via osmotic mini-pumps and blood pressure monitored during 15 days of feeding with chow diet containing vehicle or resveratrol.

Results:
Oxidation of the phenolic rings of resveratrol paradoxically leads to oxidative modification of proteins, explained by formation of a reactive quinone that oxidizes the thiolate side chain of cysteine residues; events that were enhanced in cells under oxidative stress. Consistent with these observations and its ability to induce vasodilation, resveratrol induced oxidative activation of PKG1α and lowered blood pressure in hypertensive wild-type mice, but not C42S PKG1α knock-in mice that are resistant to disulfide activation.

Conclusions:
Resveratrol mediates lowering of blood pressure by paradoxically inducing protein oxidation, especially during times of oxidative stress, a mechanism that may be a common feature of antioxidant molecules.
Reproductive potential of South African thermophilic Meloidogyne populations, with special reference to Meloidogyne enterolobii
Authors: Rashidifard Milad , Marais Mariette , Daneel Mieke S. , Fourie Hendrika 
Published: May 2019

Summary
Variability in the reproductive potential of Meloidogyne spp. is crucial to design suitable nematode management strategies. The reproductive potential of nine South African single-species Meloidogyne populations, M. enterolobii (5), M. incognita (2) and M. javanica (2), as well as three mixed-species communities (each containing two of the three species) were determined in glasshouse experiments. A mixed-species community of M. enterolobii and M. javanica had the highest reproductive potential (Rf = 15.7) in the initial experiment. For the repeat experiment, a single-species population of M. javanica was the most injurious (Rf = 19.1). Conversely, a single-species population of M. enterolobii had the lowest Rf values in the initial (Rf = 1.0) and repeat (Rf = 6.1) experiments. Substantial variation existed in terms of the reproductive potential of M. enterolobii single-species populations and mixed-species communities.
Sexual dimorphism in some morphological traits of three European millipedes (Diplopoda, Julida, Julidae)
Authors: Ilić Bojan S. , Vujić Vukica D. , Jovanović Zvezdana S. , Pavković-Lučić Sofija B. , Dudić Boris D. , Lučić Luka R. , Makarov Slobodan E. 
Published: May 2019

Abstract
Sexual size and shape dimorphism (SSD and SShD) are understudied phenomena in millipedes. In the present study, we investigated both kinds of sexual dimorphism in some morphological traits, as well as whether shape of the morphological traits varied more than their size. Three julidan species, viz., Pachyiulus hungaricus (Karsch, 1881), Megaphyllum unilineatum (C.L. Koch, 1838), and M. bosniense (Verhoeff, 1897), were used for these purposes. By means of traditional and geometric morphometrics, we found that SSD exists in linear measurements of the tested morphological traits, as well as SShD of the legs in all analysed species. Also, SSD of antennal centroid size was detected in P. hungaricus and M. unilineatum, in addition to SShD of antennae in P. hungaricus and M. bosniense. Our results indicate that morphological intersexual differences are species-specific and that the shape of some morphological traits varies more than the size of centroids of the same structures.
Al-Shaybānī and Contemporary Renunciant Piety
Authors: Melchert Christopher 
Published: May 2019

Abstract
Renunciation (zuhd) was a major part of the social and intellectual background of jurists’ circles during the formative period of Ḥanafi legal doctrine. Accordingly, the works attributed to Muḥammad b. al-Ḥasan al-Shaybānī (d. 189/804-5) touch on renunciant concerns, especially the incomplete Kitāb al-Kasb (Book of Gain). A discussion of al-Shaybānī’s views on renunciation together with comments taken from other renunciant literature shows that, although he affirms some renunciant values, he usually seems to uphold a more world-embracing piety. This puts al-Shaybānī in opposition to a section of the nascent school favouring more extreme forms, such as the repudiation of gain (inkār al‑kasb).
A Lacuna in the New Imām University Edition of al-Basīṭ: A Critical Edition of Q 4:41-53 and a Review
Authors: Saleh Walid A. , Ally Shuaib 
Published: May 2019

Abstract
One of the masterpieces of the medieval Qurʾān commentary tradition is al-Basīṭ by the Nishapuri philologist and Qurʾān scholar, Abū l-Ḥasan ʿAlī b. Aḥmad b. Muḥammad al-Wāḥidī (d. 468/1076). It was the first Qurʾān commentary to start quoting Sībawayhi (d. ca. 180/796) extensively; it was also the first to position al-Zajjāj (d. 311/923) as a central authority in Qurʾān exegesis (tafsīr), a process already started by al-Wāḥidī’s teacher al-Thaʿlabī (d. 427/1035). Al-Basīṭ is a massive Qurʾān commentary, by any standard. The critical Imām University Edition of 2009 spans twenty-five volumes. It is rather unfortunate that this edition has left the task of studying the manuscript transmission of the work out of the picture. As a result, there is a lacuna in the edition covering verses Q 4:41-53, a substantial portion. In this article, an overview of the transmission history of the work is presented, followed by a critical edition of the missing part.
An account on the Orthoptera from Siargao Island (Southeast Asia: Philippines: Mindanao)
Authors: TAN MING KAI , BAROGA-BARBECHO JESSICA B. , YAP SHERYL A. 
Published: May 2019

Siargao Island is located on the southeastern part of the Philippines. We have very little knowledge on the Orthoptera from this island which is covered with forest over limestone, open vegetation, and mangrove, despite being designated as one of the terrestrial Key Biodiversity Areas (KBAs) in the Philippines. We conducted surveys in 2018 to search for orthopterans. In total, thirty-seven species from 34 genera were found. Seventeen species are recorded in Siargao Island for the first time, representing 45.9% of all collected species, thus, validating that orthopterans in the island are indeed overlooked. Out of the 37 species, 21 of these are endemic to the Philippines and 9 are endemic to Siargao Island, hence suggesting that species on the island can be biologically significant.. We also observed that a huge proportion of the species in Siargao Island are fully winged and capable of flight, but most species are small sized. We also provide taxonomic notes and illustrations, including descriptions of the male Segestidea punctipennis Bolívar, 1903 and female Eumecopoda reducta Hebard, 1922 for the first time. We inferred that species from Siargao Island are closely associated with Sundaland and for within Philippines, Mindanao and Luzon.
Tumor necrosis factor receptor-associated protein 1 regulates hypoxia-induced apoptosis through a mitochondria-dependent pathway mediated by cytochrome c oxidase subunit II
Authors: Xiang Fei , Ma Si-yuan , Lv Yan-ling , Zhang Dong-xia , Song Hua-pei , Huang Yue-sheng 
Published: May 2019

AbstractBackgroundTumor necrosis factor receptor-associated protein 1 (TRAP1) plays a protective effect in hypoxic cardiomyocytes, but the precise mechanisms are not well clarified. The study is aimed to identify the mechanism of TRAP1 on hypoxic damage in cardiomyocytes.MethodsIn this study, the effects of TRAP1 and cytochrome c oxidase subunit II (COXII) on apoptosis in hypoxia-induced cardiomyocytes were explored using overexpression and knockdown methods separately.ResultsHypoxia induced cardiomyocyte apoptosis, and TRAP1 overexpression notably inhibited apoptosis induced by hypoxia. Conversely, TRAP1 silencing promoted apoptosis in hypoxic cardiomyocytes. Further investigation revealed that the proapoptotic effects caused by the silencing of TRAP1 were prevented by COXII overexpression, whereas COXII knockdown reduced the antiapoptotic function induced by TRAP1 overexpression. Additionally, changes in the release of cytochrome c from mitochondria into the cytosol and the caspase-3 activity in the cytoplasm, as well as reactive oxygen species production, were found to be correlated with the changes in apoptosis.ConclusionsThe current study uncovered that TRAP1 regulates hypoxia-induced cardiomyocyte apoptosis through a mitochondria-dependent apoptotic pathway mediated by COXII, in which reactive oxygen species presents as an important component.
PROSPeCT: A Predictive Research Online System for Prostate Cancer Tasks
Authors: Cutumisu Maria , Vasquez Catalina , Uhlich Maxwell , Beatty Perrin H. , Hamayeli-Mehrabani Homeira , Djebah Rume , Murtha Albert , Greiner Russell , Lewis John D. 
Published: May 2019

PURPOSE An online clinical information system, called Predictive Research Online System Prostate Cancer Tasks (PROSPeCT), was developed to enable users to query the Alberta Prostate Cancer Registry database hosted by the Alberta Prostate Cancer Research Initiative. To deliver high-quality patient treatment, prostate cancer clinicians and researchers require a user-friendly system that offers an easy and efficient way to obtain relevant and accurate information about patients from a robust and expanding database. METHODS PROSPeCT was designed and implemented to make it easy for users to query the prostate cancer patient database by creating, saving, and reusing simple and complex definitions. We describe its intuitive nature by exemplifying the creation and use of a complex definition to identify a “high-risk” patient cohort. RESULTS PROSPeCT was made to minimize user error and to maximize efficiency without requiring the user to have programming skills. Thus, it provides tools that allow both novice and expert users to easily identify patient cohorts, manage individual patient care, perform Kaplan Meier estimates, plot aggregate PSA views, compute PSA-doubling time, and visualize results. CONCLUSION This report provides an overview of PROSPeCT, a system that helps clinicians to identify appropriate patient treatments and researchers to develop prostate cancer hypotheses, with the overarching goal of improving the quality of life of patients with prostate cancer. We have made available the code for the PROSPeCT implementation at https://github.com/max-uhlich/e-PROSPeCT .
MEMES, RACISMO E EDUCAÇÃO, OU POR QUE OS MEMES DA TAÍS ARAÚJO IMPORTAM
Authors: Cardoso Junior Leonardo Fraga , De Jesus Oliveira Kaio Eduardo , Porto Cristiane De Magalhães 
Published: May 2019

Este artigo tem como objetivo discutir a importância dos memes de redes sociais digitais na Cibercultura e como eles favorecem a reprodução de discursos racistas na internet. Para isso, tomou-se como objeto o caso dos memes racistas que tencionam o debate sobre racismo a partir da fala da atriz brasileira Taís Araújo em uma edição do TEDx Brasil. A produção de memes articuladas a este caso específico, insere os usuários no debate sobre preconceito social e racial no Brasil a partir de uma fala própria que se expande na rede, especialmente permeada pelo humor e pela sátira de cada meme, mas é ampliada a partir do contexto ético e moral que toma a repercussão. Utiliza-se como método a pesquisa qualitativa, de cunho exploratório e descritivo. Ao final, evidencia-se que os memes racistas presentes nas redes sociais fortalecem o racismo no debate público, visto que ampliam por meio do conteúdo irônico e superficial deste memes propriamente, um discurso que não remete ao sentido original do fato, mas que ganha dimensões hiperbólicas em sentidos distintos na rede e na produção de sentidos e subjetividades dos indivíduos imersos na rede.
Prevalência de sintomas depressivos no idoso hospitalizado: estudo comparativo
Authors: Serra Marcela Araujo , Nascimento Isabela Maria Tavares do , Guimarães Gilberto De Lima , Silva Silmar Maria da , Goveia Vania Regina , Mendoza Isabel Yovana 
Published: May 2019

Objetivo: Comparar a prevalência dos sintomas depressivos no idoso hospitalizado, mediante uso da Escala de Depressão Geriátrica–15 e por meio da avaliação realizada pelo enfermeiro na admissão do idoso. Método: Estudo descritivo de abordagem transversal em hospital público de ensino. Utilizou-se a Escala de Depressão Geriátrica e instrumento com lista de sintomas depressivos, extraídos das características definidoras dos diagnósticos de enfermagem. Resultados: A prevalência de sintomas depressivos em idosos hospitalizados foi de 47%, segundo a Escala de Depressão Geriátrica, e de 25% segundo a avaliação do enfermeiro, no momento da admissão do paciente. Conclusão: A avaliação realizada pelo enfermeiro detectou baixa porcentagem dos sintomas depressivos no idoso em comparação ao instrumento específico para depressão.
Recursos humanos e materiais para prevenção de lesão por pressão
Authors: Tonole Renato , Brandão Euzeli 
Published: May 2019

Objetivo: Refletir acerca da importância dos recursos humanos e materiais na perspectiva da prevenção de lesão por pressão. Conteúdo: Trata-se de um estudo de reflexão pautado na literatura cientifica e de políticas públicas recente relacionada ao tema. Apesar da disponibilidade de escalas de avaliação de risco do cliente, as condições do cenário em que o mesmo está inserido muitas vezes não são favoráveis para realização dos cuidados de forma efetiva e individualizada. Dependendo das condições estruturais, o risco do cliente pode ser potencializado pela falta de recursos humanos e materiais. Conclusão: Os recursos humanos e materiais são imprescindíveis na realização das intervenções direcionadas para prevenção de lesão por pressão. A disponibilidade de um instrumento para avaliação de tais recursos poderá contribuir para caracterizar o cenário onde o cliente está inserido, avaliando se os recursos disponíveis podem prestar uma assistência segura e livre de danos.
How specialist palliative care nurses identify patients with existential distress and manage their needs
Authors: Fay Zara , OBoyle Colm 
Published: May 2019

Background: Existential distress is a term used when patients who are coming towards the end of their lives exhibit profound suffering, related particularly to their thoughts on life and existence. The clinical expression of this phenomenon has not been widely researched, and so specialist palliative care nurses were asked how they identify and manage this patient cohort. Aims: To explore how palliative-care nurses identify patients with existential distress and manage their needs. Methods: A qualitative descriptive design with thematic content analysis of transcribed interviews. Findings: Behavioural changes, agitation, social withdrawal and communication difficulties are identified as indicators of possible existential distress. Susceptible patient groups are identified. Nurses acknowledged that caring for patients with existential distress can be emotionally demanding. Being present and building relationships with patients are identified as enabling meaning-making. Sedation for refractory distress is seen as a last resort. Conclusion: Early identification of existential distress by carers could enable timely intervention (counselling, psychotherapy and or spiritual guidance) to improve the patients' quality of life in the terminal phase of their illness and avoid intractable or refractory existential distress that may necessitate palliative sedation.