bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between lifestyle factors and completion of neoadjuvant chemotherapy for breast cancer.
Authors: Usiskin Ilana M , Li Fangyong , Irwin Melinda L , Cartmel Brenda , Sanft Tara Beth 
Published: May 2018

91 Background: Completion of chemotherapy has been associated with improved breast cancer outcomes. We evaluated whether lifestyle factors, such as physical activity and diet, may contribute to neoadjuvant chemotherapy completion in breast cancer. Methods: We conducted a retrospective study of women treated with neoadjuvant chemotherapy for early stage (I-III) breast cancer. A medical record review recorded BMI, blood pressure, diabetes and hypertension medication, and chemotherapy completion. Completers received full doses of all prescribed chemotherapy, with or without cycle delays. We conducted a telephone survey about exercise and fruit/vegetable intake (>5 servings/day) during the year prior to cancer diagnosis. Exercisers completed at least 7.5 MET-hours/week (i.e., 150 minutes of moderate-intensity exercise). Multi-variable adjusted analyses were conducted to identify factors associated with chemotherapy completion. Results: Sixty-seven patients (45%) answered the survey. Chemotherapy completers were on average 11 years younger than non-completers (p<0.001), more likely premenopausal (p=0.02), and less likely on diabetes medication (p=0.05). Exercisers were more likely to complete chemotherapy than non-exercisers (p=0.002). After controlling for age, diastolic blood pressure, menopausal status, and diabetes medication, the adjusted odds ratio for exercise on chemotherapy completion was 4.1 (95% CI 1.1 – 15.3) (p=0.04). Conclusions: Women who reported exercising at recommended levels in the year prior to breast cancer diagnosis were more likely to complete neoadjuvant chemotherapy regimens, suggesting a potentially important role for lifestyle factors in chemotherapy completion. Factors associated with chemotherapy completion [Table: see text]
Four-year effects of physical exercise during adjuvant treatment on fatigue and physical activity in breast and colon cancer patients.
Authors: May Anne Maria , Hiensch Anouk E , Witlox Lenja , Velthuis Miranda , Van Der Wall Elsken , Peeters Petra H.M. ,   PACT study group
Published: May 2018

99 Background: A recent randomized trial, the PACT study, showed beneficial effects on fatigue and physical fitness after an 18-week supervised exercise program in breast and colon cancer patients undergoing adjuvant treatment. So far, little is known on long-term effects of exercising during adjuvant treatment on fatigue and whether physical activity levels could be maintained. The latter is important to preserve achieved beneficial health effects. The present study assessed effects of the exercise intervention on fatigue and physical activity on average 4 years after participation in the PACT study. Methods: The PACT study was a 2-armed, multicenter randomized controlled trial comparing an 18-week supervised exercise program to usual care among 204 breast cancer patients and 33 colon cancer patients undergoing adjuvant treatment including chemotherapy. Of the 237 participants, 197 patients were eligible and approached to participate in the 4-year follow-up measurements, and finally 128 patients responded (intervention (n = 70), usual care (n = 58)). Fatigue (MFI) and physical activity levels (SQUASH) was assessed at baseline, post-intervention (at 18 weeks), 36-week post-baseline and 4 years post-baseline. Results: Intention-to-treat mixed linear model analyses showed that cancer patients in the intervention group experienced less physical fatigue at 4-year post-baseline compared to the usual care group (-1.13, 95% CI -2.45;0.20, effect size (ES) = 0.22), although not statistically significant. Furthermore, cancer patients in the intervention group reported significantly higher moderate-to-vigorous total physical activity levels (141.77 min/week (CI 95% 1.31;281.61, ES = 0.22) after 4 years compared to the usual care group. Conclusions: Breast and colon cancer patients, who participated in an 18-week exercise intervention during adjuvant treatment, showed significant higher levels of moderate-to-vigorous total physical activity levels and a tendency towards lower physical fatigue levels 4-year post-baseline. Exercise during chemotherapy might be a promising strategy for minimizing treatment-related side-effects both in the short- and long-term. Clinical trial information: NTR2138.
High DPP-4 Concentrations in Adolescents Are Associated With Low Intact GLP-1
Authors: Stenlid Rasmus , Manell Hannes , Halldin Maria , Kullberg Joel , Ahlström Håkan , Manukyan Levon , Weghuber Daniel , Paulmichl Katharina , Zsoldos Fanni , Bergsten Peter , Forslund Anders 
Published: May 2018

Abstract

Context
Dipeptidyl peptidase 4 (DPP-4) metabolizes glucagon-like peptide-1 (GLP-1), and increased DPP4 levels are associated with obesity and visceral adiposity in adults.

Objective
Investigating DPP-4 levels in adolescents and their association with (1) circulating intact GLP-1 levels and glucose tolerance; (2) body mass index (BMI); and (3) visceral, subcutaneous, and liver fat compartments.

Design
Cross-sectional study, July 2012 to April 2015.

Setting
Pediatric obesity clinic, Uppsala University Hospital.

Patients and Participants
Children and adolescents with obesity (n = 59) and lean controls (n = 21) aged 8 to 18 years.

Main Outcome Measures
BMI SD score, fasting plasma concentrations of DPP-4, total and intact GLP-1, fasting and oral glucose tolerance test (OGTT) concentrations of glucose, and visceral adipose tissue (VAT) and subcutaneous adipose tissue volumes and liver fat fraction.

Results
Plasma DPP-4 levels decreased with age in both obese (41 ng/mL per year) and lean subjects (48 ng/mL per year). Plasma DPP-4 levels were higher in males in both the obesity and lean groups. With adjustments for age and sex, plasma DPP-4 level was negatively associated with intact GLP-1 at fasting (β = −12.3; 95% CI: −22.9, −1.8) and during OGTT (β = −12.1; 95% CI: −22.5, −1.7). No associations were found between DPP-4 and plasma glucose levels measured at fasting or after a 2-hour OGTT. Plasma DPP-4 level was 19% higher in obese subjects. Among adipose tissue compartments, the strongest association was with VAT (β = 0.05; 95% CI: −0.02, 0.12).

Conclusions
In adolescents, high plasma DPP-4 concentrations were associated with low proportions of intact GLP-1, high BMI, young age, and male sex. The observed associations are compatible with increased metabolism of GLP-1 in childhood obesity.
Contraceptive Provision to Postpartum Women With Intellectual and Developmental Disabilities: A Population‐Based Cohort Study
Authors: Brown Hilary K. , Kirkham Yolanda A. , Lunsky Yona , Cobigo Virginie , Vigod Simone N. 
Published: May 2018

CONTEXTWomen with intellectual and developmental disabilities who experience pregnancy, like all women, require postpartum care that supports their contraceptive knowledge and decision making. Yet, little is known about the postpartum contraceptive care these women receive, or how it compares with care given to other women.METHODSA population‐based study using linked health and social services administrative data examined provision of postpartum contraceptive care to women who had a live birth in Ontario, Canada, in 2002–2014 and were beneficiaries of Ontario's publicly funded drug plan. Modified Poisson regression was used to compare care between 1,181 women with and 36,259 women without intellectual and developmental disabilities. Outcomes were provision of any nonbarrier contraceptive in the year following the birth and type of method provided.RESULTSIn the first year postpartum, women with intellectual and developmental disabilities were provided with contraceptives at a higher rate than were other women (relative risk 1.3); the difference was significant for both nonsurgical and surgical methods (1.2 and 1.8, respectively). The higher rate of nonsurgical contraceptive provision was explained by provision of injectables (1.9); there were no differences for pills or IUDs.CONCLUSIONNonbarrier contraceptives may be the most appropriate methods for some women with intellectual and developmental disabilities. However, future research should investigate why women with such disabilities are more likely than others to receive injectable contraceptives, which have possible negative side effects, and surgical contraception, which is irreversible. Research also should investigate how these women perceive their participation in contraceptive decision making.
Building a Small Cinema: Resisting Neoliberal Colonization in Liverpool
Authors: Kilick Anthony 
Published: May 2018

In its stated aim of “creating cinemas not supermarkets,” the Small Cinema project voiced its alterity to the recent redevelopment of Liverpool’s city center and those of other former industrial cities throughout the Midlands and the north of the UK. These regeneration projects addressed the problem of a shrinking manufacturing base by replacing them with service industries, a move which has entailed the privatization of vast tracts of public space. Conversely, the building, functioning, and general praxis of the Small Cinema project suggests a mode of practice that more accurately fits within the paradigm of a collaborative commons than a capitalist marketplace. The project’s exemption from market criteria grants it the freedom to pursue public over private goods, thereby constituting a point of resistance to the ongoing neoliberalization of the city and changes to government policy that make it increasingly difficult for non-profit projects to exist.
Historically speaking, cinemas have been accessible to the working class in a way that other artistic media have not. However, while the history of film as a tool for political subversion is well documented, less attention has been paid to the physical construction of independent cinematic space, its programming/running, and its potential as a node of resistance to neoliberal colonization. This paper uses the case study of the Small Cinema project in Liverpool as a means by which to understand how cinematic spaces can counteract the effects of policies that continue to have such a detrimental impact on the arts and education, as well as social health and well-being.
Negotiating Creativity on a Small Budget
Authors: Møller Andersen Mads 
Published: May 2018

Abstract
This article presents findings from a production analysis of the Danish public-service television channel DR3’s fiction production Anton 90, which was made in cooperation with a small independent production company called New Creations. In the context of intensified competition on the Danish market for fiction series, the ambivalent cooperation behind this production exemplifies the low-budget efforts of a traditional public service institution to produce the fiction series that their younger target audience desires. The article uses a narrative-discursive approach to creativity and develops the term creative assumptions in order to analyse how media professionals’ implicit assumptions about conditions for creativity can influence the production process, and can generate disagreements. The analysis shows that the value of Anton 90 as a product is negotiated socially by the involved parties who have quite different assumptions about how production conditions can promote creativity, and suggests that a low-budget production can still be labelled as “successful”.
Selection of Cuculidae to the Hosts Based on the External Characteristics of the Eggs
Authors: Widodo Wahyu , Widiyaningrum Priyantini 
Published: May 2018

Most of Cuculidae were known as parasitic birds, and they breed depend on their hosts. The obyective of the study was to know the external characteristics of the eggs of Cuculidae and their hosts which includes several components. e.i. shell color, shape, length, diameter and egg index. Those species of Cuculidae were Cacomantis merulinus lanceolatus, Cacomantis variolus sepulcralis, Surniculus lugubris lugubris and Eudynamys scolopaceus malayanus. There were 117 item of the bird egg reference’s collections in the Ornithology Laboratory, Zoology Division, Research Center for Biology, LIPI, in Cibinong, used as a research materials. Color and form the egg from every sample noted by pursuant to direct eyesight with the eye if possible and assisted with the magnifier, especially at flimsy spots egg’s color. The results shown that egg size of Cuculidae groups are bigger than their host eggs. Generally, the color variation of eggs of Cuculidae and their hosts are white or bluish white and their combination like as brown and greenish. The eggs shape of Cuculidae and host are similar, namely oval with IFO value about 73 - 75%. The Cuculidae family pays attention to the color, spot pattern and shape of the host’s eggs in choosing the host for their own eggs. Though, there was also a tendency not to recognize the characteristic of the host’s egg. The studies represent an early stage in an attempt to strive the conservation of Cuculidae the bird hosts.
Loss of Elongation-Like Factor 1 Spontaneously Induces Diverse, RNase H-Related Suppressor Mutations in Schizosaccharomyces pombe
Authors: Marayati Bahjat F , Drayton Alena L , Tucker James F , Huckabee Reid H , Anderson Alicia M , Pease James B , Zeyl Clifford W , Zhang Ke 
Published: May 2018

Abstract
A healthy individual may carry a detrimental genetic trait that is masked by another genetic mutation. Such suppressive genetic interactions, in which a mutant allele either partially or completely restores the fitness defect of a particular mutant, tend to occur between genes that have a confined functional connection. Here we investigate a self-recovery phenotype in Schizosaccharomyces pombe, mediated by suppressive genetic interactions that can be amplified during cell culture. Cells without Elf1, an AAA+ family ATPase, have severe growth defects initially, but quickly recover growth rates near to those of wild-type strains by acquiring suppressor mutations. elf1Δ cells accumulate RNAs within the nucleus and display effects of genome instability such as sensitivity to DNA damage, increased incidence of lagging chromosomes, and mini-chromosome loss. Notably, the rate of phenotypic recovery was further enhanced in elf1Δ cells when RNase H activities were abolished and significantly reduced upon overexpression of RNase H1, suggesting that loss of Elf1-related genome instability can be resolved by RNase H activities, likely through eliminating the potentially mutagenic DNA–RNA hybrids caused by RNA nuclear accumulation. Using whole genome sequencing, we mapped a few consistent suppressors of elf1Δ including mutated Cue2, Rpl2702, and SPBPJ4664.02, suggesting previously unknown functional connections between Elf1 and these proteins. Our findings describe a mechanism by which cells bearing mutations that cause fitness defects and genome instability may accelerate the fitness recovery of their population through quickly acquiring suppressors. We propose that this mechanism may be universally applicable to all microorganisms in large-population cultures.
The Cycle of Child Protection Services Involvement: A Cohort Study of Adolescent Mothers
Authors: Wall-Wieler Elizabeth , Brownell Marni , Singal Deepa , Nickel Nathan , Roos Leslie L. 
Published: May 2018

OBJECTIVES:
To determine if adolescent mothers who were in the care of child protection services (CPS) when they gave birth to their first child are more likely to have that child taken into CPS care before the child’s second birthday than adolescent mothers who were not in the care of CPS.

METHODS:
Linkable administrative data were used to create a population-based cohort of adolescent mothers whose first child was born in Manitoba, Canada between April 1, 1998, and March 31, 2013 (n = 5942). Adjusted odds ratios (aOR) of having that first child taken into care before their second birthday were compared between mothers who were in care (n = 576) and mothers who were not in care (n = 5366) at the birth of their child by using logistic regression models.

RESULTS:
Adolescent mothers who were in care had greater odds of having their child taken into care before the child’s second birthday (aOR = 7.53; 95% confidence interval [CI] = 6.19–9.14). Specifically, their children had higher odds of being taken into care in their first week of life (aOR = 11.64; 95% CI = 8.83–15.34), between 1 week and their first birthday (aOR = 3.63; 95% CI = 2.79–4.71), and between their first and second birthday (aOR = 2.21; 95% CIl = 1.53–3.19).

CONCLUSIONS:
Findings support an intergenerational cycle of involvement with CPS. More and better services are required for adolescent mothers who give birth while in care of CPS.
O dever de resistir: sobre escolas, professores e sociedade
Authors: Biesta Gert , Picoli Bruno Antonio 
Published: May 2018

Nas sociedades contemporâneas existem muitas expectativas sobre o que as escolas devem fazer. Estas incluem a instrumentalização de crianças e jovens para o mundo do trabalho, a sua transformação em cidadãos democráticos ou a criação de uma sociedade coesa e inclusiva. O que une essas expectativas é que elas se aproximam da escola como uma espécie de instrumento para resolver problemas da sociedade. A escola é tratada como tendo uma função para a sociedade e, portanto, como uma instituição que deve ser funcional e útil para ela. O perigo dessa maneira de pensar é que outras questões – como o que a escola deve cuidar ou proteger – desaparecem facilmente do campo de visão. Neste artigo, explora-se como se pode responder à pergunta sobre qual é a “tarefa” especial e exclusiva da escola, argumentando que esta não deve ser vista apenas como tendo uma função para a sociedade, mas também como tendo um dever importante de resistir às demandas que a sociedade deseja que sejam atendidas.****************************************************************** Bruno Antonio Picoli (tradutor)
Sois vosotros valientes héroes. Somos nosotros simples humanos". La experiencia de la guerra del pacífico en los testimonios de los actores
Authors: Coronado Canales David Angelo 
Published: May 2018

Resumen en español.La victoria chilena obtenida en la Guerra del Pacífico no sólo es objeto de análisis desde una perspectiva bélica con énfasis en las estrategias o los combates como meta-relatos dignos de la Historia nacional, como un discurso que permita unir en torno de éste a una comunidad nacional, sino que además es relevante escuchar los testimonios de los actores y rescatar sus voces para saber qué nos dicen.Nuestra hipótesis trata de como el discurso oficial de la Historiografía chilena y el recuerdo de la misma Guerra han postergado elementos de historicidad fundamentales para la comprensión de las experiencias de vida de estos hombres cuyos testimonios han perdurado para que podamos descifrar sus subjetividades sobre su vida en campaña.El presente artículo se sitúa en una recopilación de testimonios de soldados chilenos de la Guerra del Pacífico que nos expresan sus subjetividades y nos clarifican el panorama acerca de qué es lo que ellos sintieron y permitiéndonos separar al “hombre del mito” y verlos como lo que realmente fueron, sujetos históricos que por diferentes móviles se vieron envueltos en una guerra en la cuál sufrieron, pelearon y sus recuerdos escritos sobrevivieron estudiarlos. AbstractSummary: the Chilean victory obtained at the War of the Pacific is not only an object of study from a military point of view, with emphasis on the strategies and battles as meta stories worthy of belonging to the History of a nation; but it also is a discourse that allows the unification of a national community around it. In addition, however, it is important to listen to the participants’ testimonies and to recover their voices to know what they are telling us.The hypothesis in this article deals with how the official discourse about the Chilean Historiography and the memory of the same war have neglected fundamental historicity elements to understand the life experiences of these men, whose testimonies have remained so that we can decipher their subjectivities about their lives in campaign.The following article is a compilation of testimonies about the War of the Pacific by Chilean soldiers, who tell us their subjectivities and clarify what they felt, allowing us to separate the “man from the myth” and see them as the men they really were, historical subjects that for different reasons found themselves involved in a war in which they suffered, fought and which they memories survive to be studied.
Las industrias azucarera y petrolera en el Zulia: formas de ocupación territorial (1913-1935)
Authors: Bermúdez Briñez Nilda , Rodríguez Arrieta Marisol 
Published: May 2018

Este artículo tiene como objetivo fundamental explicar las distintas formas de apropiación y ocupación de las tierras ubicadas al este y al sur del estado Zulia, situado al occidente de Venezuela, en donde los capitales criollos y extranjeros representados en compañías anónimas invirtieron recursos económicos con la finalidad de instalar las industrias azucareras y petroleras que monopolizaron en poco tiempo extensos territorios para la exploración y explotación de la caña de azúcar y del petróleo. Ambos procesos cabalgaron en diferentes ritmos históricos, con desiguales actores sociales pero en tiempos análogos. La industrialización de estos rubros requirió de amplios espacios que adquirieron y modificaron los líderes de las corporaciones en la medida que lograban comprar, traspasar, negociar, contratar, desalojar y hasta expropiar tierras, casas, animales, fundos, hatos, haciendas o labores agrícolas privadas y públicas, apoyados en la legislación de la época, en sus relaciones con la municipalidad y con el gobierno del general Juan Vicente Gómez. La libertad y el respaldo que gozaron los socios de ambas empresas los llevó a transformar la infraestructura tradicional y adecuarla a las exigencias de las corporaciones que se consolidaban: por primera vez en el país, se instalaron novedosos equipos y maquinarias manejados con tecnologías modernas que requirió de un personal competente y de mano de obra abundante. En este trabajo se utilizó el método histórico como herramienta científica para el abordaje y análisis del tema.
La Historia del Corporativismo en Europa. Aproximación a las formas jurídico-políticas de representación del Trabajo.
Authors: Fernández Riquelme Sergio 
Published: May 2018

El trabajo siguiente presenta una aproximación historiográfica al desarrollo jurídico y político de la representación estatal del Trabajo en Europa. En su itinerario señalamos tres dimensiones de estudio (retrospectiva, perspectiva y prospectiva) siguiendo el paradigma de la Historia de las ideas, buscando el significado de las fórmulas corporativas como modalidad de la “política técnica”. Así nuestra historia transcurre desde mediados del siglo XIX hasta los albores del siglo XXI; periodo donde subrayamos las principales ideas y los autores destacados, desde la hipótesis de la pluralidad doctrinal en su origen histórico, las coincidencias ideológicas entre ideologías supuestamente adversas como instrumento político-social, y la pervivencia de ciertos de sus postulados en el Estado social y de derecho actual.