bluuebunny/crossref_metadata_2025_split huggingface dataset:
Schlafstörungen und schlafassoziierte Erkrankungen beim Glaukom
Authors: Weissleder Stephanie , Klemm Maren 
Published: February 2019

ZusammenfassungDas gleichzeitige Auftreten von Schlafstörungen und Glaukom könnte in einem Zusammenhang stehen. Es gibt bisher keine konkreten Studien darüber, wie häufig und warum Schlafstörungen bei Glaukompatienten auftreten, jedoch liegen verschiedene Ansätze vor, die sowohl einen Zusammenhang zwischen dem Auftreten von Schlafstörungen im Verlauf einer Glaukomerkrankung als auch zwischen dem Auftreten eines Glaukoms und bestimmten Schlafgewohnheiten herstellen.
Frühe oder kurzzeitige Insulintherapie bei Typ-2-Diabetes: Stellenwert und Risiko-Nutzen-Bilanz im Rahmen individualisierter Therapiekonzepte
Authors: Hanefeld Markolf , Fleischmann Holger , Liebl Andreas , Siegmund Thorsten 
Published: February 2019

ZusammenfassungTrotz großer Fortschritte in der Qualität der Diabetestherapie wird der Anteil des Diabetes an der Gesamtsterblichkeit in Deutschland mit ca. 20 % angegeben. Diabetesbezogene Komplikationen sind wieder zum Schicksal vieler Patienten (im Besonderen Senioren) mit langer Diabetesdauer geworden. Die Prävention dieser Komplikationen erfordert eine frühe Diagnose sowie eine rasche und konsequente Glykämiekontrolle für den Erhalt und die Remission der residualen B-Zell-Funktion sowie den Schutz des Endothels vor Gluko- und Lipotoxizität. Die glykämische Last gilt für Makro- und Mikroangiopathien im Prinzip gleichermaßen. Mit den bahnbrechenden Ergebnissen der Outcome-Studien mit SGLT2-Inhibitoren und GLP1-Analoga ist sowohl in den Leitlinien als auch in der täglichen klinischen Praxis Bewegung in die Rangfolge der Antidiabetika gekommen. Angesichts dieser sehr positiven Entwicklung muss insofern das Postulat der frühen Insulintherapie im Rahmen einer individualisierten, risikoadjustierten Behandlung überprüft werden. Dieses White Paper demonstriert anhand von gut dokumentierten, kontrollierten Studien, dass bei klinisch kranken Patienten klare Indikationen für eine initiale, intensivierte Insulintherapie bereits zu Beginn des Diabetes gegeben sind. Die Insulintherapie zeigt im Vergleich zu anderen antidiabetischen Behandlungsstrategien den schnellsten Effekt in Bezug auf die Zielerreichung und Glukolipotoxizität. Im Hinblick auf die überwiegende Multimorbidität der Patienten und langanhaltende Remissionen – bis zu 50 % nach 2 Jahren – ist dies außerdem kosteneffektiv. Allerdings sind die Vorteile der frühen Insulintherapie nicht direkt übertragbar auf den langjährigen Diabetes. Jedoch ändert sich da die Situation, wenn nach Ausschöpfung aller Therapieoptionen für orale Antidiabetika und GLP1-Analoga eine weitere Verschlechterung des Diabetes zu beobachten ist oder diabetesbedingte Komplikationen vermehrt auftreten. In diesen Fällen können die positiven Effekte der frühzeitigen Insulinisierung ebenso in Betracht gezogen werden.
Endoscopic ultrasound-guided radiofrequency ablation for pancreatic neuroendocrine tumors and pancreatic cystic neoplasms: a prospective multicenter study
Authors: Barthet Marc , Giovannini Marc , Lesavre Nathalie , Boustiere Christian , Napoleon Bertrand , Koch Stéphane , Gasmi Mohamed , Vanbiervliet Geoffroy , Gonzalez Jean-Michel 
Published: February 2019

Abstract
Background Pancreatic neuroendocrine tumors (NETs) and intraductal pancreatic mucinous neoplasia (IPMN) with worrisome features are surgically managed. Endoscopic ultrasound (EUS)-guided radiofrequency ablation (RFA) has recently been developed. The safety of EUS-RFA was the primary end point of this study, its efficacy the secondary end point.
Methods This was a prospective multicenter study that was planned to include 30 patients with a 1-year follow-up with either a NET < 2 cm or a pancreatic cystic neoplasm (PCN), either a branch duct IPMN with worrisome features or a mucinous cystadenoma (MCA). EUS-RFA was performed with an 18G RFA cooling needle.
Results 12 patients had 14 NETs (mean size 13.1 mm, range 10 – 20 mm); 17 patients had cystic tumors (16 IPMNs, 1 MCA; mean size 28 mm, range 9 – 60 mm). Overall three adverse events occurred (10 %), two of these in the first two patients (one pancreatitis, one small-bowel perforation). After these initial patients, modifications in the protocol resulted in a decrease in complications (3.5 %), with one patient having a pancreatic ductal stenosis. Among the 14 NETs, at 1-year follow-up 12 had completely disappeared (86 % tumor resolution), with three patients having a delayed response. Among the 17 PCNs, at 12 months, there were 11 complete disappearances and one diameter that decreased by > 50 % (significant response rate 71 %). All 12 mural nodules showed complete resolution.
Conclusions EUS-RFA of pancreatic NETs or PCNs is safe with a 10 % complication rate, which can be decreased by improved prophylaxis for the procedure.
Current Trend of Invasive Orthopaedic Interventions for People with Haemophilia in Romania: Single Centre Experience
Authors: Serban Margit , Poenaru Dan Vasile , Patrascu Jenel Marian , Ritli Ladislau , Boia Eugen , Mihailov Delia Maria , Ursu Cristina Emilia , Savescu Delia , Ionita Ioana , Traila Adina , Cerbu Simona , Boeriu Estera , Jinca Cristian , Schramm Wolfgang , Arghirescu Smaranda 
Published: February 2019

Objective In countries with low factor concentrate consumption, disabling joint disease remains the major morbidity in patients with haemophilia. The objective of the present analysis is to express the trend and profile of invasive orthopaedic interventions in our country with low usage of factor replacement, lacking the prophylaxis program until recent years.
Patients and Methods This retrospective descriptive study was conducted in our university centre in Timisoara with long-lasting experience in haemophilia care, which succeeded in developing an exceptionally valuable genuine comprehensive inter-institutional cooperation. This study refers to 115 invasive interventions performed on 97 patients: 83 with haemophilia A, 10 with haemophilia B and 4 with von Willebrand disease in the period of 2001 to 2017; 17 of them had inhibitors, 5 developing inhibitors after the intervention.
Results and Discussion The cohort of patients consisted mostly of young adults, aged between 7 and 49 years. The vast majority of them, 91.3% of the patients, had the burden of severe chronic arthropathy. This was the reason for 95 interventions, with programmed solution. In 20 cases the cause of invasive interventions was emergency. Knee and hip replacement represented 28% of the major interventions. The complications we encountered were excessive bleeding (12.2%), infection (13%) and inhibitor development (4.3%).
Conclusion Surgery is a demanding intervention in patients with haemophilia, which unfortunately cannot be ignored in our country. Hopefully, the improved availability and accessibility to replacement therapy will eliminate the necessity of these interventions, optimizing the outcomes for the next generations.
Novel Neuropathological Features of a Child with an Epileptic Encephalopathy Due to Presumed Polyol Dysmetabolism
Authors: Marsh Eric David , Bergqvist Anna Gunhild Christina , Medne Livija , Hassoun Patrice , Gonatas Nicholas Konstantinos , Eagle Ralph C. , Viaene Angela Nicole , Rorke-Adams Lucy Balian 
Published: February 2019

AbstractDisorders of carbohydrate metabolism resulting in accumulation of polyols in body fluids were first described in the early 1990s by van der Knapp et al, but this diagnosis remains rare with very few patients reported with primary neurological phenotypes. We present a child with a presumed polyol disorder whose clinical course was similar to two of the original five patients and who had similar findings in quantification of urinary polyols. In addition, we document details of central nervous system pathology in this rare metabolic disorder. The basic pathology is that of a neurodegenerative disorder with hypomyelination leukodystrophy consequent to a defect of oligodendroglia and resultant axonal and neuronal loss.
Cystinosis: A Rare Case Presentation
Authors: Hantodkar Karan , Mohite Mahesh , Deshpande Pankaj 
Published: February 2019

AbstractCystinosis is a systemic disease caused by defect in metabolism of Cystine. It typically presents as Fanconi syndrome with metabolic acidosis, polyuria, failure to thrive, glucosuria, phophaturia and aminoaciduria. Our patient did not display metabolic acidosis at presentation and had features suggesting Bartter's syndrome.
Methemoglobinemia After Isolated Lidocain Spray: A Rare Phenomenon
Authors: Khandelwal Priyank , Malani Rachna , Kothari Soor , Prakash Tannvi , Malik Amer 
Published: February 2019

AbstractMethemoglobinemia is a state recognized by the increased production of met-hemoglobin, which is a form of oxidized hemoglobin, which is unable to bind oxygen. As a result the patient has a functional anemia, in which the remaining oxyhemoglobin has increased oxygen affinity, shifting the oxygen curve to left and perpetuating the impairment of oxygen delivery to tissues. Methemoglobinemia is a rare, but serious cause of hypoxemia, which can be difficult to recognize. It has been traditionally associated with the use of benzocaine class of anesthetic agents and FDA has issued warning for the use of benzocaine class of anesthetic agents for the same reason. It has been very seldom reported with the use of lidocaine class of agents alone. Through this case report we want to emphasize development of methemoglobinemia through the isolated use of lidocaine.
Acardiac – Acephalus Twin – A Rare Case Report and Review of Literature
Authors: Mital Mukta , Garg Tanuj , Gupta Prashant , Nanda Vinit 
Published: February 2019

AbstractAcardiac twin pregnancy is a rare complication of monochorionic twinning caused by aterioarterial and venovenous placental anastomosis, leading to circulatory predominance of one twin (1). The donor “pump’ twin provides circulation for itself as well as and for the recipient acardiac twin. The acardiac twin is usually grossly abnormal with severe reduction anamolies of the upper part of the body. We present a case of acephalus acardiac anomaly diagnosed by ultrasound, with subsequent post delivery followup.
Beware of Foreign Body Sensation” This Live Worm can Swim Through Your Eye! - A Case Series on Increasing Prevalance of Ocular Dirofilariasis in Tropical India: A Disease of Travel to Foreign Lands
Authors: Guptha Sruthi , TC Ranjakumar , Sundaram Lalith , Ashraf Rahana , Adil Syed , Hisham Mohammad 
Published: February 2019

AbstractThe purpose is to report a case series of increasing prevalence of ocular Dirofilariasis in tropical areas of South India and the importance of the disease with travel to tropical areas Human Dirofilariasis, caused by Dirofilaria repens, have been reported to occur widely throughout Asia, Europe, and Africa. The Dirofilaria are natural parasites of mammals and are transmitted to man by zooanthrophilic mosquitoes. It is emphasized that both clinicians and microbiologists should have an increased awareness of this entity and include dirofilariasis in the differential diagnosis of patients presenting with subcutaneous nodules. Excision of the lesion is both diagnostic and therapeutic.
Quantum chemical methods in charge density studies from X-ray diffraction data
Authors: Korlyukov Alexander A. , Nelyubina Yulia V. 
Published: February 2019

Single-crystal X-ray diffraction studies are among the best experimental methods for elucidating the structure of chemical compounds. Recently, their focus has been shifted towards extracting information on chemical bonding features and related valuable properties of these compounds from the analysis of charge density distribution obtained in high-resolution X-ray diffraction experiments; the latter are possible only for a limited number of well-ordered crystals of small molecules. In this review, the hybrid approaches are described that introduce quantum chemical methods into the refinement of X-ray diffraction data. Their use significantly extends the range of systems suitable for charge density studies (such as polypeptides, metal-organic frameworks, inclusion compounds and others) and the scope of problems that they solve, viz., from protein structure refinement to determination of thermodynamic or other wave function-derived properties of crystals. The potential of these hybrid approaches and prospects for their future applications are discussed.
The bibliography includes 322 references.
Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive
Authors: Oberhofer Georg , Ivy Tobin , Hay Bruce A. 
Published: February 2019

SignificanceThere is great interest in spreading beneficial traits throughout wild populations in self-sustaining ways. Here, we describe a synthetic selfish genetic element,CleaveR[Cleave and Rescue (ClvR)], that is simple to build and can spread a linked gene to high frequency in populations.ClvRis composed of two components. The first, germline-expressed Cas9 and guide RNAs (gRNAs), cleave and disrupt versions of an essential gene located elsewhere in the genome. The second, a version of the essential gene resistant to cleavage, provides essential gene function.ClvRspreads by creating conditions in which progeny lackingClvRdie because they have no functional copies of the essential gene. In contrast, those who inheritClvRsurvive, resulting in an increase inClvRfrequency.
Metaphorical motion in Chinese
Authors: Shan Xinxin , Onchoke Aunga Solomon 
Published: February 2019

AbstractThis paper focuses onmetaphorical motionin the Chinese language by investigating how various abstract concepts are construed in terms of spatial motion. The claim that the primary metaphor,change is motion, is central to metaphorical motion is confirmed, and we further examine sorts of target domains that are structured by spatial motion, the corresponding mappings in metaphors of entity-location pairs and orientational metaphors. Moreover, we explore how systematicity and complexity have structured the whole system. Through systematicity, coherence between different mappings and within one mapping are analyzed, and two concepts of “event” – event in “event-structure concepts” and in “motion event frame” are observed and are shown to be interrelated. By means of complexity, the specific issue ofentity-location dualityin metaphorical motion is discussed, and experiential bases – including physical, social and cultural basis for metaphorical motion is also considered.
Cross-cultural conceptualizations of ageing in Australia
Authors: Huang Hui , Sharifian Farzad , Feldman Susan , Yang Hui , Radermacher Harriet , Browning Colette 
Published: February 2019

AbstractIn this paper, the framework of Cultural Linguistics is employed to examine how older people from two different ethnic backgrounds in Australia conceptualize ageing and their own experience of ageing. The paper employs a qualitative method for the instantiations of interviews from two focus groups of Australian women. The results indicated that women of Anglo-Celtic background had a more self-oriented perception of ageing, aged care and self, while women of Chinese background had a more relational outlook. However, the evidence indicated that changes were taking place in both traditions despite a certain degree of continuity.
Metonymies and metaphors of sadness in the Old English vocabulary
Authors: Castaño Emilia Castaño , Verdaguer Clavera Isabel 
Published: February 2019

AbstractThe aim of this paper is to explore the predominant metonymic and metaphoric conceptualizations of sadness in the Old English period. To this end, the Old English expressions for emotional distress recorded inThe Old English Thesaurusand old English dictionaries have been analyzed. Taking as a starting point the experiential grounding of emotion conceptualization, we first present experimental evidence in support of the role of somato-behavioral reactions in emotion recognition, affective state induction and emotional information processing and interpretation, and review the most common metonymic and metaphoric expressions for sadness in Modern English. Next, we analyze the Old English vocabulary for sadness and the interplay between embodiment and culture in the conceptualization and linguistic description of emotional distress. Such analysis makes it clear that in ancient times, as in present day English, sadness and psychological distress were also conceptualized in terms of unpleasant physical conditions such as illness, cold, darkness or heaviness. Consequently, a long-term diachronic trend in the conceptualization of sadness can be traced even though its linguistic realization and motivation have varied through time.
The time of human thoughts and deeds
Authors: Hovhannisyan Gayane R. 
Published: February 2019

AbstractA mysterious part of our physical and psychological models of the world is Time. Its cognitive representation has evolved from Mythology through Literature to Physics. In ancient times, it was Kala of the Indo-Europeans, Chronos of the Greek gods, and the Kirke of Odyssey whose world could make heroes forget about anything. Then came Renaissance, the gradual awakening of the Time of Soul, the swing of philosophical mind between material and ideal worlds, its acceleration to the Relativity of Einstein, and the recent collapse on the Quantum Theory and to new biocentric passages. Shakespeare’s world of human mind and characters is so diverse and opulent, that anyone can find and emulate natural and supernatural phenomena in it, getting food for philosophical, psychological contemplation and even ideas for quantum-physical speculations. The truth is that Time molds the world of matter with the subjective world of human dreams and deeds.
Environmental manifestoes
Authors: Rodrigues Soledade , Lewiński Marcin , Ali Üzelgün Mehmet 
Published: February 2019

AbstractIn this paper, we analyze the argumentative strategies deployed in theEcomodernist Manifesto, published in 2015 by a group of leading environmental thinkers. We draw on pragma-dialectics and Perelman’s rhetoric to characterize manifesto as a genre of practical argumentation. Our goal is to explore the relation of manifesto as a discursive genre to the argumentative structures and techniques used in theEcomodernist Manifesto. We therefore take into scrutiny the elements of practical argumentation employed in the manifesto and describe the polylogical strategies of dissociation in negotiating the ecological value of nature and the modernist value of progress.
Battlefield EU
Authors: Takovski Aleksandar 
Published: February 2019

AbstractEU is a discursive field where multiple meanings and representations are created, negotiated and contested. Research has shown that the concept possess an interpretive power often used as an instrument of political confrontation. Such is the case, this study argues, with the two largest Macedonian parties – VMRO-DPMNE and the Social Democrats – who in a pursuit of changing or maintaining the power structuration in the society have produced a discourse on EU that best fits their political agendas. In a situation of a prolonged political crisis, and a significant involvement of EU, the two parties have commodified the discourse on EU into an instrument of self-promotion and/or criticism of the other. Demonstrating the instrumental use of the representations of EU by analysing the discursive strategies and the linguistic means deployed are the general aims of this study.
Submaximal heart rate seems inadequate to prescribe and monitor intensified training
Authors: ten Haaf Twan , Foster Carl , Meeusen Romain , Roelands Bart , Piacentini Maria Francesca , van Staveren Selma , Koenderman Leo , de Koning Jos J. 
Published: February 2019

ABSTRACTThe aim of this study is to investigate whether the change in (sub)maximal heart rate after intensified training is associated with the change in performance. Thirty subjects were recruited who performed cardiopulmonary exercise tests to exhaustion 2 weeks before (pre), 1 week after (post) and 5 weeks after (follow‐up) an 8‐day non‐competitive amateur cycling event (TFL). The exercise volume during the TFL was 7.7 fold the volume during the preparation period. Heart rate and cardiopulmonary parameters were obtained at standardised absolute submaximal workloads (low, medium and high intensity) and at peak level each test. Subjects were classified as functionally overreached (FOR) or acute fatigued (AF) based on the change in performance. No differences between FOR and AF were observed for heart rate (P = .51). On total group level (AF + FOR), post‐TFL heart rate decreased significantly at low (−4.4 beats·min−1, 95% CI [−8.7, −0.1]) and medium (−5.5 beats·min−1 [−8.5, −2.4]), but not at high intensity. Peak heart rate decreased −3.4 beats·min−1 [−6.1, −0.7]. O2pulse was on average 0.49 ml O2·beat−1 [0.09, 0.89] higher at all intensities after intensified training. No changes in ⩒O2 (P = .44) or the ventilatory threshold (P = .21) were observed. Pearson's correlation coefficients revealed negative associations between heart rate and O2pulse at low (r = −.56, P < .01) and medium intensity (r = −.54, P < .01), but not with ⩒O2 or any other submaximal parameter. (Sub)maximal heart rate decreased after the TFL. However, this decrease is unrelated to the change in performance. Therefore, heart rate seems inadequate to prescribe and monitor intensified training.
Network inference performance complexity: a consequence of topological, experimental and algorithmic determinants
Authors: Muldoon Joseph J , Yu Jessica S , Fassia Mohammad-Kasim , Bagheri Neda 
Published: February 2019

Abstract

Motivation
Network inference algorithms aim to uncover key regulatory interactions governing cellular decision-making, disease progression and therapeutic interventions. Having an accurate blueprint of this regulation is essential for understanding and controlling cell behavior. However, the utility and impact of these approaches are limited because the ways in which various factors shape inference outcomes remain largely unknown.

Results
We identify and systematically evaluate determinants of performance—including network properties, experimental design choices and data processing—by developing new metrics that quantify confidence across algorithms in comparable terms. We conducted a multifactorial analysis that demonstrates how stimulus target, regulatory kinetics, induction and resolution dynamics, and noise differentially impact widely used algorithms in significant and previously unrecognized ways. The results show how even if high-quality data are paired with high-performing algorithms, inferred models are sometimes susceptible to giving misleading conclusions. Lastly, we validate these findings and the utility of the confidence metrics using realistic in silico gene regulatory networks. This new characterization approach provides a way to more rigorously interpret how algorithms infer regulation from biological datasets.

Availability and implementation
Code is available at http://github.com/bagherilab/networkinference/.

Supplementary information
Supplementary data are available at Bioinformatics online.