bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foot orthoses for people with rheumatoid arthritis: a survey of prescription habits among podiatrists
Authors: Chapman Lara S. , Redmond Anthony C. , Landorf Karl B. , Rome Keith , Keenan Anne‐Maree , Waxman Robin , Alcacer‐Pitarch Begonya , Siddle Heidi J. , Backhouse Michael R. 
Published: January 2019

AbstractBackgroundGuidelines recommend foot orthoses for people with both early (< 2 years) and established rheumatoid arthritis (RA). While prefabricated foot orthoses are cheaper and can exhibit comparable effects to customised devices, the available evidence for their effectiveness is inconsistent. Little is known about what types of foot orthoses clinicians prescribe. This study describes the foot orthoses prescription habits of podiatrists for people with rheumatoid arthritis.MethodsOne hundred and eighty‐three podiatrists from the United Kingdom (UK) (n = 88), Australia (n = 68) and New Zealand (n = 27) completed a self‐administered, online survey regarding the types of foot orthoses prescribed in clinical practice for people with RA. This study forms part of a wider international survey exploring foot orthosis prescription habits.ResultsUK respondents were more likely to prescribe prefabricated orthoses for early RA (n = 47, 53%) and customised orthoses for established RA (n = 47, 53%). Respondents in Australia were more likely to prescribe customised orthoses for both early (n = 32, 47%) and established (n = 46, 68%) RA, whilst respondents in New Zealand were more likely to prescribe prefabricated orthoses for both early (n = 16, 59%) and established (n = 10, 37%) disease.Irrespective of disease stage, the use of foam impression boxes was more prevalent in the UK and New Zealand when capturing a model of the feet prior to manufacturing customised orthoses. In contrast, electronic scanning and plaster of Paris were more common in Australia. Computer aided manufacture was utilised more frequently among respondents in Australia than in the UK and New Zealand. Respondents in all three countries specified more flexible shell materials for established RA, compared to early disease. Cushioning top covers (e.g. PORON® or polyurethane) were most frequently specified in all countries for both disease stages.ConclusionsConsiderable variation was seen in the self‐reported foot orthoses prescription habits of respondents for people with RA. Variation between countries and disease stage was seen in type of orthoses, specific brands, manufacturing methods, and materials prescribed. The results allow podiatrists and broader health service providers to compare their practice against reported national and international patterns.
Validation of the Chinese Manchester foot pain and disability index (C‐MFPDI) among patients with inflammatory arthritis
Authors: Erh Brina Xing Ying , He Hong‐gu , Carter Kate Frances , Cheung Peter P. , Tan Daphne S. , Wang Wenru , Rome Keith 
Published: January 2019

AbstractBackgroundThe Manchester Foot Pain and Disability Index (MFPDI) is a patient‐reported outcome tool used to measure foot pain and foot‐related disability. The English version of the MFPDI has been successfully translated into other European languages, but there was no Chinese version to use in Chinese‐speaking communities. The cross‐sectional correlational study aimed to translate the MFPDI from English into simplified Chinese (C‐MFPDI) and to test its psychometric properties among people with inflammatory arthritis in Singapore.MethodsThe MFPDI was translated from English into Chinese using a forward‐backward translation framework and was administered to 100 Chinese‐speaking people with inflammatory arthritis. From the original 100 participants, 30 participants re‐evaluated the C‐MFPDI after 2 weeks. A Visual Analogue Scale and the Taiwan Chinese Foot Function Index in simplified Chinese were used to evaluate concurrent validity with the C‐MFPDI. Health‐related quality of life was assessed using the Chinese version of the European Quality of Life‐5 Dimension to test construct validity.ResultsThe C‐MFPDI had a high translation equivalent rate (96.3%) and content validity index (0.92), good internal consistency (Cronbach's α = 0.90) and test‐retest reliability (ICC = 0.87). The concurrent validity of the C‐MFPDI was demonstrated to be acceptable through its significantly moderate to strong positive correlations with the Taiwan Chinese Foot Function Index (r = 0.62–0.72, p < 0.01) and Visual Analogue Scale foot pain (r = 0.65, p < 0.01). The C‐MFPDI total scores were moderately negatively associated with Chinese European Quality of Life‐5 Dimension utility scores (r = − 0.40, p < 0.01).ConclusionThe C‐MFPDI had good psychometric properties. The C‐MFPDI can be used to assess disabling foot pain, impairment and disability in Chinese‐speaking people with inflammatory arthritis.
GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation
Authors: Giacomello Emiliana , Ronchi Paolo , Pepperkok Rainer 
Published: January 2019

ABSTRACT
Skeletal muscle (SKM) differentiation is a highly regulated process leading to the formation of specialised cells with reorganised compartments and organelles, such as those of the early secretory pathway. During SKM differentiation the Golgi complex (GC) redistributes close to the nuclear envelope and in small distinct peripheral structures distributed throughout the myotube. Concurrently, GC elements closely associate with endoplasmic reticulum-exit sites (ERES). The mechanisms underlying this reorganisation and its relevance for SKM differentiation are poorly understood. Here, we show, by time-lapse imaging studies, that the changes in GC organisation involve GC fragmentation and redistribution of ERES with the formation of tightly associated GC–ERES units. We show that knockdown of GM130 (also known as GOLGA2) or p115 (also known as USO1), two regulators of the early secretory pathway, impairs GC and ERES reorganisation. This in turn results in inhibition of myotube fusion and M-cadherin (also known as CDH15) transport to the sarcolemma. Taken together, our data suggest that the correct reorganisation of the early secretory pathway components plays an important role in SKM differentiation and, thus, associated pathologies.
Case Report: Concurrent primary CNS lymphoma and meningothelial meningioma - nuances of diagnosis and management
Authors: Kashyap Samir , Bernstein Jacob , Bowen Ira , Menoni Rosalinda , Miulli Dan 
Published: January 2019

Background: The incidence of two distinct primary intracranial pathologies is an exceedingly rare phenomenon. Although meningiomas are well known to coexist with other primary intracranial malignancies there are only nine reported cases of a meningioma occurring simultaneously with primary CNS lymphoma in the literature. We report a case of a woman who sustained multiple injuries due to two distinct intracranial pathologies, however, lateralizing signs were unrecognized for two weeks prior to her final diagnosis. Case Description: A 64-year-old female with history of diabetes mellitus type 2 initially presented to the Emergency Department, two weeks prior, following a mechanical fall at home resulting in a left bimalleolar fracture. CT imaging revealed a right occipital mass with significant vasogenic edema causing 12mm of midline shift. MRI revealed two distinct homogeneously contrast-enhancing lesions: a right occipital mass with dural-based attachment, as well as a homogenously contrast-enhancing lesion adjacent to the right posterolateral ventricle. FLAIR signal changes were also appreciated and were noted to extend across the corpus callosum, raising concerns for a high-grade glial process. She underwent a right occipital craniotomy with gross total resection of the right occipital mass as well as subtotal resection and biopsy of the second lesion. Final pathology of the extra-axial lesion was found to be meningothelial meningioma and the deep lesion was found to be diffuse large B-cell lymphoma. Discussion: We describe a rare instance of simultaneous meningioma and primary CNS lymphoma that was found to be the underlying cause of a traumatic injury several weeks after the incident. We review the current diagnosis and management nuances in the setting of multiple intracranial oncologic processes.
The study of protein recruitment to UV-induced DNA lesions can be distorted by photoconversion of DNA dyes like Hoechst or DAPI
Authors: Hurst Verena , Gasser Susan M. 
Published: January 2019

A common approach used to assess DNA repair factor binding in mammalian cells is to induce DNA damage with a UV laser and follow the movement of GFP-tagged proteins to the site of damage. Often these measurements are performed in the presence of the blue DNA intercalating dye Hoechst or DAPI, which is used to label nuclear DNA. A UV-induced switch of Hoechst and DAPI from a blue-light to a green-light emitter will give a false positive signal at the site of damage. Thus, photoconversion signals must be subtracted from the overall green-light emission to determine true recruitment. Here we demonstrate the photoconversion effect and suggest control experiments to exclude false-positive results.
Resolving outbreak dynamics using approximate Bayesian computation for stochastic birth-death models
Authors: Lintusaari Jarno , Blomstedt Paul , Sivula Tuomas , Gutmann Michael U. , Kaski Samuel , Corander Jukka 
Published: January 2019

Earlier research has suggested that approximate Bayesian computation (ABC) makes it possible to fit simulator-based intractable birth-death models to investigate communicable disease outbreak dynamics with accuracy comparable to that of exact Bayesian methods. However, recent findings have indicated that key parameters such as the reproductive number R may remain poorly identifiable with these models. Here we show that the identifiability issue can be resolved by taking into account disease-specific characteristics of the transmission process in closer detail. Using tuberculosis (TB) in the San Francisco Bay area as a case-study, we consider a model that generates genotype data from a mixture of three stochastic processes, each with their distinct dynamics and clear epidemiological interpretation. We show that our model allows for accurate posterior inferences about outbreak dynamics from aggregated annual case data with genotype information. As a by-product of the inference, the model provides an estimate of the infectious population size at the time the data was collected. The acquired estimate is approximately two orders of magnitude smaller compared to the assumptions made in the earlier related studies, and much better aligned with epidemiological knowledge about active TB prevalence. Similarly, the reproductive number R related to the primary underlying transmission process is estimated to be nearly three-fold compared with the previous estimates, which has a substantial impact on the interpretation of the fitted outbreak model.
Mbembe, Achille. Necropolítica. São Paulo: N-1 edições, 2018, 80p. ISBN 9788566943504
Authors: MARQUES MATHEUS SOUSA , PEREIRA TAINAH 
Published: January 2019

Este trabalho resenha o ensaio Necropolítica, do filósofo camaronês Achille Mbembe, recentemente republicado em 2018. O autor demonstra como a questão da soberania deve levar em conta, na contemporaneidade, não somente uma questão de autonomia individual e de busca pela liberdade, mas também o caráter de morte nela presente. Nesse sentido, Mbembe compreende a soberania como a expressão máxima de poder e capacidade de decisão sobre quais vidas merecem ser vividas e quais corpos são matáveis.ABSTRACTThis paper presents a review of the essay Necropolitics by Achille Mbembe, a Cameroonian philosopher, recently republished in 2018. The author demonstrates how the question of sovereignty must not only take into account, in contemporary times, a question of individual autonomy and the search for freedom, but also the character of death in it. In this sense, Mbembe understands sovereignty as the ultimate expression of power and decision-making capacity over which lives deserve to be lived and which bodies are killable.Palavras-chave: Estado de Exceção; Biopoder; SoberaniaKeywords: State of Exception; Biopower; SovereignRecebido em 13 de Dezembro de 2018 | Received on December 13, 2018Aceito em 19 de Dezembro de 2018 | Accepted on December 19, 2018DOI
Amazonia viajeros. Los viajeros y la reflexión sobre la Amazonia en los últimos cien años
Authors: Meirelles Filho João , Martins Fernanda 
Published: January 2019

En pleno siglo XXI, incluso a pesar de la gran cantidad de medios tecnológicos y de comunicación disponibles, nuestra visión sobre la Amazonia, sus pueblos y comunidades se asemeja, en gran medida, a la de un viajero del siglo XIX. Seguimos refiriéndonos a ella como Tierra Incognita, un espacio salvaje, bosque exótico, vacío, riquezas infinitas de El Dorado, infierno verde, en resumen, la mítica visión eurocentrista de la Amazonia-espectáculo. Ni siquiera el fin de ciclo del “boom del caucho” fue suficiente para despertar una profunda reflexión sobre la región, fuera por los propios amazonidas (de los nueve países del bioma amazônico) o por los brasileños en general, especialmente por los primeros, ya que son los que sufren las consecuencias de este hecho. Mientras tanto, en los últimos cien años algunos viajeros, individualmente o en grupo, han ampliado nuestra visión con el fin de discutir la Amazonia y sus complejidades a través de una nueva mirada, menos preconcebida, más cariñosa y generosa. Este artículo refleja la producción textual e inconográfica (incluyendo el soporte de las nuevas tecnologías) de algunos de estos pensadores que recorrieron la Amazonia brasileña para entender su legado; y, al mismo tiempo, presenta caminos para esta reflexión necesaria sobre la Amazonia por parte de sus habitantes, de los brasileños y por la civilización contemporánea para que las actuales generaciones tengan una visión más responsable de la Amazonia.
Setas como hábitos alimentarios de los indios Yanomami - saberes asociados a la ciencia, a la preservación y a la defensa de la selva amazónica
Authors: Tsuji Nishikido Linda Midori 
Published: January 2019

Sanuma, O. I., & Tokimoto, K. et al. (2016). Sanöma samakönö sama tökö nii pewö ao wi ? tökö waheta: anaamopö = Enciclopédia dos alimentos Yanomami (sanöma): cogumelos. São Paulo: Instituto Socioambiental.En la obra de Sanoma samakono sama toko nii pewo ao wi i toko waheta: anaamopo = Enciclopedia de los alimentos Yanomami (sanoma): setas, esta reseña objetiva analizar los estudios sobre setas comestibles consumidas por el grupo indígena san?ma perteneciente a la etnia Yanomami, observando, igualmente, otros saberes desarrollados por los indios, como el control sistemático de la roza, fundamentales para la conservación y defensa de la selva amazónica. La importancia de la obra se establece por la revelación de un conocimiento alimenticio poco común de los indígenas como son las setas, asociada al saber científico, siendo galardonada con el Premio Jabuti en 2017, en la categoría Gastronomía. Es una producción bilingüe en lengua sanoma y portugués, y la investigación es una colaboración entre los profesores san?ma y diversos centros de investigación. Dentro de ese contexto, NoemiaKazue Ishikawa y KeisukeTokimoto tuvieron un papel fundamental actuando como investigadores y mediadores, cuyo resultado es la presente obra.
Improvement of Viability of Lactobacillus casei and Bifidobacterium longum with Several Encapsulating Materials using Extrusion Method
Authors: Widaningrum . , Miskiyah . , Indrasti D , Hidaya HC 
Published: January 2019

<p class="abstrak2">Lactobacillus casei and Bifidobacterium longum are probiotics commonly applied as dry starter for food system. Drying process in the production of dry starter can reduce the number of probiotics, therefore they are necessary to be encapsulated. Aim of this research was to obtain best encapsulating material for both probiotics. Encapsulation technique used in this research was extrusion with maltodextrine-alginate, sago starch-alginate, corn starch-alginate, and control of treatment skim milk-alginate (w:w) as encapsulating materials. The four encapsulating materials significantly affected the value of viability, encapsulation efficiency, number of cell in wet beads and dry beads, number of survival cell during drying process, and number of survival encapsulated cell in simulated acid and bile salt conditions. Based on viability of L. casei and B. longum, beads matrix characteristic, number of cell in wet beads and dry beads, and number of survival cells during drying process, maltodextrine-alginate was better than sago starch-alginate and corn starch-alginate, but was not as good as skim milk-alginate (control of treatment) as encapsulating material. Viability (number) of L. casei and B. longum in dry beads of maltodextrine-alginate were 4.69±0.08 log CFU/g and 5.32±0.21 log CFU/g, while number of L. casei and B. longum in dry beads of skim milk-alginate were higher 5.08±0.07 log CFU/g and 6.20±0.16 log CFU/g. L. casei more resistant than B. longum against acidic (low pH) environment. In the presence of 0.3% bile salt, L. casei and B. longum encapsulated with skim milk-alginate increased as much as 2.75±0. 02 and 1.61±0.04 log cycles, respectively.</p>
Convergence of Riemannian 4-manifolds with L2L^{2}-curvature bounds
Authors: Zergänge Norman 
Published: January 2019

Abstract
In this work we prove convergence results of sequences of Riemannian 4-manifolds with almost vanishing

L
2

{L^{2}}

-norm of a curvature tensor and a non-collapsing bound on the volume of small balls.
In Theorem 1.1 we consider a sequence of closed Riemannian 4-manifolds, whose

L
2

{L^{2}}

-norm of the Riemannian curvature tensor tends to zero.
Under the assumption of a uniform non-collapsing bound and a uniform diameter bound, we prove that there exists a subsequence that converges with respect to the Gromov–Hausdorff topology to a flat manifold.
In Theorem 1.2 we consider a sequence of closed Riemannian 4-manifolds, whose

L
2

{L^{2}}

-norm of the Riemannian curvature tensor is uniformly bounded from above, and whose

L
2

{L^{2}}

-norm of the traceless Ricci-tensor tends to zero.
Here, under the assumption of a uniform non-collapsing bound, which is very close to the Euclidean situation, and a uniform diameter bound, we show that there exists a subsequence which converges in the Gromov–Hausdorff sense to an Einstein manifold.
In order to prove Theorem 1.1 and Theorem 1.2, we use a smoothing technique, which is called

L
2

{L^{2}}

-curvature flow.
This method was introduced by Jeffrey Streets.
In particular, we use his “tubular averaging technique” in order to prove distance estimates of the

L
2

{L^{2}}

-curvature flow, which only depend on significant geometric bounds.
This is the content of Theorem 1.3.
On the monotonicity of the principal frequency of the p-Laplacian
Authors: Bocea Marian , Mihăilescu Mihai 
Published: January 2019

Abstract
For any fixed integer

D
>
1

{D>1}

we show that there exists

M
∈

[

e

-
1

,
1
]

{M\in[e^{-1},1]}

such that
for any open, bounded, convex domain

Ω
⊂

ℝ
D

{\Omega\subset{\mathbb{R}}^{D}}

with smooth boundary for which the maximum of the distance function to the boundary
of Ω is less than or equal to M, the principal frequency of the p-Laplacian on Ω is an increasing function of p on

(
1
,
∞
)

{(1,\infty)}

. Moreover, for any real number

s
>
M

{s>M}

there exists an open, bounded, convex domain

Ω
⊂

ℝ
D

{\Omega\subset{\mathbb{R}}^{D}}

with smooth boundary which
has the maximum of the distance function to the boundary of Ω equal to s such that the principal frequency of the p-Laplacian is
not a monotone function of

p
∈

(
1
,
∞
)

{p\in(1,\infty)}

.
Quantum Kostka and the rank one problem for 𝔰𝔩2m
Authors: Hobson Natalie L. F. 
Published: January 2019

Abstract
We give necessary and sufficient conditions to specify vector bundles of conformal blocks for 𝔰𝔩2m
with rectangular weights which have ranks 0, 1, and larger than 1. We show that the first Chern classes of such rank one bundles determine a finitely generated subcone of the nef cone.
Is a complete, reduced set necessarily of constant width?
Authors: Brandenberg René , Merino Bernardo González , Jahn Thomas , Martini Horst 
Published: January 2019

Abstract
Is it true that a convex body K being complete and reduced with respect to some gauge body C is necessarily of constant width, i.e. does it satisfy K − K = ρ(C − C) for some ρ > 0? We prove this implication for several cases including the following: if K is a simplex or if K contains a smooth extreme point, then the implication holds. Moreover, we derive several new results on perfect norms.
Superforms, tropical cohomology, and Poincaré duality
Authors: Jell Philipp , Shaw Kristin , Smacka Jascha 
Published: January 2019

Abstract
We establish a canonical isomorphism between two bigraded cohomology theories for polyhedral spaces: Dolbeault cohomology of superforms and tropical cohomology. Furthermore, we prove Poincaré duality for cohomology of tropical manifolds, which are polyhedral spaces locally given by Bergman fans of matroids.
Nonlinear Scalar Field Equations with L
2 Constraint: Mountain Pass and Symmetric Mountain Pass Approaches
Authors: Hirata Jun , Tanaka Kazunaga 
Published: January 2019

Abstract
We study the existence of radially symmetric solutions of the following nonlinear scalar field equations in

ℝ
N

{\mathbb{R}^{N}}

(

N
≥
2

{N\geq 2}

):

${(*)_{m}}$

{

-

Δ
⁢
u

=

g
⁢

(
u
)

-

μ
⁢
u

in
⁢

ℝ
N

,

∥
u
∥

L
2

⁢

(

ℝ
N

)

2

=
m

,

u
∈

H
1

⁢

(

ℝ
N

)

,

\displaystyle\begin{cases}-\Delta u=g(u)-\mu u\quad\text{in }\mathbb{R}^{N},% \cr\lVert u\rVert_{L^{2}(\mathbb{R}^{N})}^{2}=m,\cr u\in H^{1}(\mathbb{R}^{N})% ,\end{cases}

where

g
⁢

(
ξ
)

∈

C
⁢

(
ℝ
,
ℝ
)

{g(\xi)\in C(\mathbb{R},\mathbb{R})}

,

m
>
0

{m>0}

is a given constant and

μ
∈
ℝ

{\mu\in\mathbb{R}}

is a Lagrange multiplier. We introduce a new approach using a Lagrange formulation of problem

(
*
)

m

{(*)_{m}}

. We develop a new deformation argument under a new version of the Palais–Smale condition. For a general class of nonlinearities related to [H. Berestycki and P.-L. Lions, Nonlinear scalar field equations. I: Existence of a ground state, Arch. Ration. Mech. Anal. 82 (1983), no. 4, 313–345], [H. Berestycki and P.-L. Lions, Nonlinear scalar field equations. II. Existence of infinitely many solutions, Arch. Ration. Mech. Anal. 82 (1983), no. 4, 347–375], [J. Hirata, N. Ikoma and K. Tanaka, Nonlinear scalar field equations in

ℝ
N

{\mathbb{R}^{N}}

: Mountain pass and symmetric mountain pass approaches, Topol. Methods Nonlinear Anal. 35 (2010), no. 2, 253–276], it enables us to apply minimax argument for

L
2

{L^{2}}

constraint problems and we show the existence of infinitely many solutions as well as mountain pass characterization of a minimizing solution of the problem

inf
⁡

{

∫

ℝ
N

1
2

⁢

|

∇
⁡
u

|

2

-

G
⁢

(
u
)

⁢
d
⁢
x

:

∥
u
∥

L
2

⁢

(

ℝ
N

)

2

=
m

}

,

G
⁢

(
ξ
)

=

∫
0
ξ

g
⁢

(
τ
)

⁢

𝑑
τ

.

\inf\Bigg{\{}\int_{\mathbb{R}^{N}}{1\over 2}|{\nabla u}|^{2}-G(u)\,dx:\lVert u% \rVert_{L^{2}(\mathbb{R}^{N})}^{2}=m\Bigg{\}},\quad G(\xi)=\int_{0}^{\xi}g(% \tau)\,d\tau.