bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Publication Bias Tests in Speech, Language, and Hearing Research
Authors: Chow Jason C. 
Published: November 2018

Purpose
The purpose of this research note is to systematically document the extent that researchers who publish in American Speech-Language-Hearing Association (ASHA) journals search for and include unpublished literature in their meta-analyses and test for publication bias.

Method
This research note searched all ASHA peer-reviewed journals for published meta-analyses and reviewed all qualifying articles for characteristics related to the acknowledgment and assessment of publication bias.

Results

Of meta-analyses published in ASHA journals, 75% discuss publication in some form; however, less than 50% test for publication bias. Further, only 38% (
n
= 11) interpreted the findings of these tests.

Conclusion
Findings reveal that more attention is needed to the presence and impact of publication bias. This research note concludes with 5 recommendations for addressing publication bias.

Supplemental Material

https://doi.org/10.23641/asha.7268648
Metazoan parasite communities of two deep-sea elasmobranchs: the southern lanternshark, Etmopterus granulosus, and the largenose catshark, Apristurus nasutus, in the Southeastern Pacific Ocean
Authors: Espínola-Novelo Juan F. , Escribano Rubén , Oliva Marcelo E. 
Published: November 2018

Two deep-sea shark species were obtained as by-catch of the local fishery of the Patagonian toothfish, Dissostichus eleginoides, at depths ranging from 1000 to 2200 m off central and northern Chile. A total of 19 parasite taxa were found in 133 specimens of the southern lanternshark, Etmopterus granulosus, (n = 120) and largenose catshark, Apristurus nasutus, (n = 13). Fourteen taxa (four Monogenea, one Digenea, four Cestoda, one Nematoda, two Copepoda, one Annelida and one Thecostraca) were found in E. granulosus, whereas five taxa (one Monogenea, two Cestoda and two Nematoda) were found in A. nasutus. Representatives of Cestoda showed higher values of prevalence and a greater intensity of infection; this pattern is consistent with reports for elasmobranchs, but the monogenean richness was higher than that previously reported for related deep-sea sharks. Regarding E. granulosus, a positive and significant correlation between host length and abundance was found for six (four ectoparasites, one mesoparasite, and one endoparasite) of the 14 taxa recorded, but prevalence was significantly correlated with host length only for the monogenean Asthenocotyle sp. Although the sample size for A. nasutus was limited, we compared richness, abundance, diversity and evenness at the infracommunity and component community levels. All of these variables were higher for E. granulosus, but at the infracommunity level, abundance was higher for A. nasutus. All the parasite taxa (except two) represent new host and geographical records.
Echokardiografie bei akuter Rechtsherzinsuffizienz
Authors: Schäfer Benedikt , Greim Clemens-Alexander 
Published: November 2018

ZusammenfassungDie akute Rechtsherzinsuffizienz wird als Ursache einer kardiopulmonalen Insuffizienz häufig übersehen und kann vital bedrohlich sein. Die verschiedenen Krankheitsbilder, die der Rechtsherzinsuffizienz ätiologisch auf Ebene der Nachlast, Vorlast und Kontraktilität zugrunde liegen, können mittels zielgerichteter Diagnostik abgeklärt werden. Neben klinischen Symptomen ist vor allem die Echokardiografie für die Diagnosestellung relevant.
Sehschärfe, Kontrastempfindlichkeit, Farbensehen: Gedanken zu psychophysischen Untersuchungen in der Neuroophthalmologie
Authors: Heinrich Sven , Hoffmann Michael 
Published: November 2018

ZusammenfassungTrotz aller technischen Fortschritte in der ophthalmologischen Diagnostik spielt die psychophysische Untersuchung der individuellen Sehleistungen weiterhin eine wichtige Rolle. Dies gilt insbesondere für neuroophthalmologische Fragestellungen. Der vorliegende Artikel betrachtet methodische und klinische Aspekte der Untersuchung von Sehschärfe, Kontrastempfindlichkeit und Farbsehvermögen. Im Gegensatz zur Sehschärfe wird die Kontrastempfindlichkeit bislang nur selten untersucht, obgleich ihre Reduktion in vielen Fällen ein sensitiverer Indikator einer Erkrankung ist. Generell haben standardisierte Verfahren, wie sie insbesondere für die Sehschärfeprüfung existieren, den Vorteil der Vergleichbarkeit. Vom Standard abweichende Verfahren können hierbei jedoch unter Umständen die spezifischen, für eine Erkrankung charakteristischen Sehstörungen besser erfassen, sodass deren Anwendung im konkreten Einzelfall gerechtfertigt ist. Dies zeichnet sich auch für die Testung des Farbensehens ab. Bisherige Studien deuten darauf hin, dass die Messung der Farbsättigungsschwelle bei erworbenen Farbsehstörungen eine effiziente und sensitive Alternative zu herkömmlichen Farbsehtests darstellen könnte.
Behandlungssteuerung – eine Herausforderung zwischen Akutmedizin und medizinischer Rehabilitation
Authors: Bagus Peter 
Published: November 2018

ZusammenfassungWenngleich die Entgiftungsbehandlung bei Alkoholabhängigkeit unstrittig von Seiten der Kostenträger als Aufgabe der Akutmedizin akzeptiert ist, so gilt dies keineswegs uneingeschränkt für die weiteren Behandlungsschritte bei zusätzlich vorliegender Essstörung und weiterer erheblicher psychischer Komorbiditäten. Die Behandlungssteuerung wird zu einer besonderen Aufgabe im Kontext des Behandlungsbedarfes. Der Einbezug der ICF (Internationale Klassifikation der Funktionsfähigkeit, Behinderung und Gesundheit) erweist sich hier als hilfreich. Die vorliegende Arbeit fokussiert schlaglichtartig die Problematik anhand einer Fallskizze. Im konkreten Fall ist schließlich Rehabilitationsfähigkeit ein wichtiges Ergebnis einer an den Leitlinien orientierten mehrmonatigen stationären Krankenhausbehandlung in 2 Fachbereichen.
Synthesis and Reactivity of Mixed Dimethylalkynylaluminum Reagents
Authors: Piccardi Riccardo , Turcaud Serge , Benedetti Erica , Micouin Laurent 
Published: November 2018

Organoaluminum derivatives are mostly appreciated for their Lewis acidity properties, but generally not considered as reagents of choice in synthetic transformations involving the creation of C–C bonds. Among these species, dimethylalkynylaluminum reagents represent a special class of compounds, with, in many cases, unique reactivity. This review summarizes the preparation and reactivity of these organometallic reagents with a focus on their synthetic potential.1	Introduction2	Preparation of Dimethylalkynylaluminum Reagents3	Reactivity of Dimethylalkynylaluminum Reagents3.1	Reactions with Csp3 Electrophiles3.2	Reactions with Csp2 Electrophiles4	Transition-Metal-Catalyzed Reactions4.1	Addition to α,β-Unsaturated Enones4.2	Coupling Reactions5	Triple Bond Reactivity6	Conclusion
Bots increase exposure to negative and inflammatory content in online social systems
Authors: Stella Massimo , Ferrara Emilio , De Domenico Manlio 
Published: November 2018

Significance
Social media can deeply influence reality perception, affecting millions of people’s voting behavior. Hence, maneuvering opinion dynamics by disseminating forged content over online ecosystems is an effective pathway for social hacking. We propose a framework for discovering such a potentially dangerous behavior promoted by automatic users, also called “bots,” in online social networks. We provide evidence that social bots target mainly human influencers but generate semantic content depending on the polarized stance of their targets. During the 2017 Catalan referendum, used as a case study, social bots generated and promoted violent content aimed at Independentists, ultimately exacerbating social conflict online. Our results open challenges for detecting and controlling the influence of such content on society.
Energy hegemony and maritime security in the Gulf of Guinea: rethinking the regional trans-border cooperation approach
Authors: Adibe Raymond , Nwangwu Chikodiri , Ezirim Gerald E. , Egonu Nnamdi 
Published: November 2018

SUMMARY
This Briefing argues that Nigeria’s hegemony over energy trade in the Gulf of Guinea maritime domain makes other states’ political commitment to regional trans-border frameworks difficult. It finds that the contradictions of rentier oil governance in Nigeria have implications for the rise in maritime insecurity in the Gulf of Guinea.
Cell migration is negatively modulated by ABCA1
Authors: Ito Shiho , Kioka Noriyuki , Ueda Kazumitsu 
Published: November 2018

ABSTRACT
Temporal and spatial changes of membrane lipid distribution in the plasma membrane are thought to be important for various cellular functions. ATP-Binding Cassette A1 (ABCA1) is a key lipid transporter for the generation of high density lipoprotein. Recently, we reported that ABCA1 maintains an asymmetric distribution of cholesterol in the plasma membrane. Here we report that ABCA1 suppresses cell migration by modulating signal pathways. ABCA1 knockdown in mouse embryonic fibroblasts accelerated cell migration and increased activation of Rac1 and its localization to detergent-resistant membranes. Phosphorylation of MEK and ERK also increased. Inhibition of Rac1 or MEK-ERK signals suppressed cell migration in ABCA1 knockdown cells. Because our experimental conditions for cell migration did not contain cholesterol or lipid acceptors for ABCA1, cellular cholesterol content was not changed. These data suggest that ABCA1 modulates cell migration via Rac1 and MEK-ERK signaling by altering lipid distribution in the plasma membrane.
Seroprevalence of Human Papillomavirus 6/11/16/18 Among Self-identified Gay/Bisexual Men Who Have Sex With Men, Men Who Have Sex With Women, and Females, United States, 2003–2010
Authors: Lewis Rayleen M , Markowitz Lauri E , Panicker Gitika , Unger Elizabeth R 
Published: November 2018

AbstractBackgroundDifferences in human papillomavirus (HPV) seroprevalence by sex have been observed, likely due to differences in the anatomic site of HPV exposure. Seroconversion may be more likely after exposure at nonkeratinized (mucosal) compared to keratinized epithelium. We compared seroprevalence among self-identified gay/bisexual men who have sex with men (MSM) and females, 2 groups more likely exposed at mucosal epithelium, and men who only have sex with women (MSW), a group likely exposed primarily at keratinized epithelium, using data from the National Health and Nutrition Examination Survey from 2003 to 2010.MethodsHPV 6/11/16/18 serum antibody was detected using a multiplexed, competitive luminex immunoassay. Weighted seroprevalence was estimated among unvaccinated, sexually experienced 18–59 year-old MSM, MSW, and females, overall and by demographic and sexual behavior characteristics. Seroprevalences were compared using prevalence ratios adjusted for sexual behavior (aPRs).ResultsOverall, seroprevalence in MSM, MSW, and females was 42.6%, 13.2%, and 37.1%, respectively. Seroprevalence in MSM was comparable to females (aPR: 0.85, 95% confidence interval [CI]: 0.68–1.08) and higher than MSW (aPR: 2.72, 95% CI: 2.19–3.38). MSW had a significantly lower seroprevalence than females (aPR: 0.31, 95% CI: 0.28–0.34). Similar associations were seen in all sociodemographic subgroups. Seroprevalence increased with number of lifetime sex partners in all groups.ConclusionsIn this population-based survey, HPV seroprevalence among groups likely exposed at mucosal epithelium (MSM, females) was comparable; seroprevalence in both groups was higher than in MSW. Future research could explore whether differences in seropositivity following infection result in differential protection from future infection.
Autonomy support in physical education promotes autonomous motivation towards leisure-time physical activity: evidence from a sample of Chinese college students
Authors: Abula Kahar , Beckmann Jürgen , He Zhongkai , Cheong Chengwa , Lu Fuquan , Gröpel Peter 
Published: November 2018

SummaryBased on the trans-contextual model, two studies aimed to test whether autonomy-supportive physical education (PE) promotes autonomous motivation towards leisure-time physical activity among Chinese college students. Study 1 was conducted in September 2015 and used a cross-sectional design. Participants were students who provided data on perceived autonomy support and motivation for physical activity. Regression analysis was used to analyze the data. Study 2 took place from September to December 2015 and employed an experimental design. Participants were PE teachers and their students. The teachers were randomized to either an intervention or a control group and those in the intervention group received a 3-month long autonomy-supportive intervention program. Their students provided data on motivation. The data were analyzed with repeated measurement analysis of variance. A total of 681 students aged 16–26 years participated in Study 1. Perceived autonomy support predicted autonomous motivation in PE (β = 0.18, P = 0.001), which in turn predicted autonomous motivation towards leisure-time physical activity (β = 0.51, P = 0.001). Ten PE teachers (28–53 years) and 258 students (16–26 years) participated in Study 2. Students who were educated by the intervention teachers had significantly stronger autonomous motivation towards leisure-time physical activity than students educated by the control teachers after the intervention, (F = 12.41, P = 0.001). The results suggest that PE may serve as an effective platform to promote an active lifestyle among Chinese college students when teachers provide students with an experience of autonomy.
Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects
Authors: Uehara Takenori , Eikawa Shingo , Nishida Mikako , Kunisada Yuki , Yoshida Aki , Fujiwara Tomohiro , Kunisada Toshiyuki , Ozaki Toshifumi , Udono Heiichiro 
Published: November 2018

Abstract
CD11b+ myeloid subpopulations, including myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), play crucial roles in the suppression of T-cell-mediated anti-tumor immunity. Regulation of these cell types is a primary goal for achieving efficient cancer immunotherapy. We found that metformin (Met) induces CD11b+-cell-mediated growth inhibition of a K7M2neo osteosarcoma independent of T cells, as growth inhibition of K7M2neo was still observed in wild-type (WT) mice depleted of T cells by antibodies and in SCID; this contrasted with the effect of Met on Meth A fibrosarcoma, which was entirely T-cell-dependent. Moreover, the inhibitory effect seen in SCID was abrogated by anti-CD11b antibody injection. PMN-MDSCs were significantly reduced in both spleens and tumors following Met treatment. In TAMs, production of IL-12 and TNF-α, but not IL-10, became apparent, and elevation of MHC class II with reduction of CD206 was observed, indicating a shift from an M2- to M1-like phenotype via Met administration. Metabolically, Met treatment decreased basal respiration and the oxygen consumption rate (OCR)/extracellular acidification rate (ECAR) ratio of CD11b+ cells in tumors, but not in the spleen. In addition, decreased reactive oxygen species (ROS) production and proton leakage in MDSCs and TAMs were consistently observed in tumors. Uptake of both 2-deoxy-2-d-glucose (2-NBDG) and BODIPY® decreased in MDSCs, but only BODIPY® incorporation was decreased in TAMs. Overall, our results suggest that Met redirects the metabolism of CD11b+ cells to lower oxidative phosphorylation (OXPHOS) while elevating glycolysis, thereby pushing the microenvironment to a state that inhibits the growth of certain tumors.
Competition and the Welfare Gains from Transportation Infrastructure: Evidence from the Golden Quadrilateral of India
Authors: Asturias Jose , García-Santana Manuel , Ramos Roberto 
Published: November 2018

Abstract
A significant amount of resources is spent every year on the improvement of transportation infrastructure in developing countries. In this paper, we investigate the effects of one such large project, the Golden Quadrilateral in India. We do so using a model of internal trade with variable markups. In contrast to the previous literature, our model incorporates several channels through which transportation infrastructure affects welfare. In particular, the model accounts for gains stemming from improvements in the allocative efficiency of the economy. We calibrate the model to the Indian manufacturing sector and find real income gains of 2.7%. We also find that allocative efficiency accounts for 7.4% of these gains. The importance of allocative efficiency varies greatly across states, and can account for up to 18% of the overall gains in some states. The remaining welfare gains are accounted for by changes in labor income, productive efficiency, and average markups that affect states’ terms of trade.
Effects of immune suppression in murine models of disseminated Candida glabrata and Candida tropicalis infection and utility of a synthetic peptide vaccine
Authors: Xin Hong 
Published: November 2018

AbstractCandida species are the second most frequent cause of fungal infections worldwide. Current knowledge of immunity to Candida has been gleaned almost exclusively from studies on Candida albicans, the most common disease-causing species. Knowledge of immunity to non-albicans Candida (NAC) species is still at an early stage due to the lack of tractable animal models with which to study these important pathogens. This is partly because many NAC species are not usually pathogenic in mouse models of candidiasis. In this study, we established an immunosuppressed mouse model of disseminated candidiasis by the two clinically important NAC species, C. glabrata and C. tropicalis. The inbred mouse strains, A/J and BALB/c, show distinct susceptibilities to disseminated Candida infection. A/J mice, deficient for complement C5, are more susceptible to disseminated infection with both C. glabrata and C. tropicalis compared to BALB/c mice, the latter having functional C5. Here we show that peptide-pulsed dendritic cell (DC) vaccination with a peptide derived from a C. tropicalis cell surface protein, significantly improved survival and reduced the fungal burdens of disseminated candidiasis in these immunocompromised mice. Importantly, this study is the first report of protective efficacy conferred by a peptide vaccine against medically important NAC species in immunosuppressed hosts. Establishing this experimental mouse model provides an important tool to further understand pathogenesis and host resistance in Candida infection. Significantly, our findings also demonstrate how this model can be used to evaluate new control strategies against candidiasis, such as vaccines.
Quantitative non-vanishing results on L-functions
Authors: Jiang Yujiao , Lü Guangshi 
Published: November 2018

Abstract
In this paper, we establish a quantitative non-vanishing result on a class of twisted L-functions A(s,χ) of degree k, which satisfy some mild and standard assumptions. As a corollary, we show that for a positive proportion of characters in a specific set, the special values A(β,χ) are non-vanishing for ℜβ>1−1k. In particular, our argument holds for Rankin–Selberg L-functions and symmetric square L-functions on certain higher rank groups, and leads to some new non-trivial results for the first time.
Factors associated with sharing email information and mental health survey participation in large population cohorts
Authors: Adams Mark J. , Hill W. David , Howard David M. , Davis Katrina A. S. , Deary Ian J. , Hotopf Matthew , McIntosh Andrew M. 
Published: November 2018

AbstractPeople who opt to participate in scientific studies tend to be healthier, wealthier, and more educated than the broader population. While selection bias does not always pose a problem for analysing the relationships between exposures and diseases or other outcomes, it can lead to biased effect size estimates. Biased estimates may weaken the utility of genetic findings because the goal is often to make inferences in a new sample (such as in polygenic risk score analysis). We used data from UK Biobank and Generation Scotland and conducted phenotypic and genome-wide association analyses on two phenotypes that reflected mental health data availability: (1) whether participants were contactable by email for follow-up) and (2) whether participants responded to a follow-up surveys of mental health. We identified nine genetic loci associated with email contact and 25 loci associated with mental health survey completion. Both phenotypes were positively genetically correlated with higher educational attainment and better health and negatively genetically correlated with psychological distress and schizophrenia. Recontact availability and follow-up participation can act as further genetic filters for data on mental health phenotypes.
Screening a Resource of Recombinant Protein Fragments for Targeted Proteomics
Authors: Edfors Fredrik , Forsström Björn , Vunk Helian , Kotol David , Fredolini Claudia , Maddalo Gianluca , Svensson Anne-Sophie , Boström Tove , Tegel Hanna , Nilsson Peter , Schwenk Jochen M. , Uhlen Mathias 
Published: November 2018

AbstractThe availability of proteomics resources hosting protein and peptide standards, as well as the data describing their analytical performances, will continue to enhance our current capabilities to develop targeted proteomics methods for quantitative biology. This study describes the analysis of a resource of 26,840 individually purified recombinant protein fragments corresponding to more than 16,000 human protein-coding genes. The resource was screened to identify proteotypic peptides suitable for targeted proteomics efforts and we report LC-MS/MS assay coordinates for more than 25,000 proteotypic peptides, corresponding to more than 10,000 unique proteins. Additionally, peptide formation and digestion kinetics were, for a subset of the standards, monitored using a time-course protocol involving parallel digestion of isotope-labelled recombinant protein standards and endogenous human plasma proteins. We show that the strategy by adding isotope-labelled recombinant proteins prior to trypsin digestion enables short digestion protocols (≤60 min) with robust quantitative precision. In a proof-of-concept study, we quantified 23 proteins in human plasma using assay parameters defined in our study and used the standards to describe distinct clusters of individuals linked to different levels of LPA, APOE, SERPINA5 and TFRC. In summary, we describe the use and utility of a resource of recombinant proteins to identify proteotypic peptides useful for targeted proteomics assay development.