bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiographic dynamics of coronary flow state after percutaneous coronary intervention in carriers of polymorphic RS1800470 variants of the TGF-β1 gene
Authors: Brusentsov D. A. , Nikulina S. Yu. , Shesternya P. A. 
Published: September 2019

Aim. To study the relationship between the angiographic dynamics of the state of the coronary bed in patients undergoing percutaneous coronary intervention (PCI) due to myocardial infarction (MI) and the carriage of polymorphic rs1800470 variants of the transforming growth factor beta-1 gene (TGF-β1).Material and methods. The study included 89 men with MI of the Caucasian race aged 32 to 65 years (52 [45,0-58,0]). Genomic deoxyribonucleic acid (DNA) was extracted from venous blood by phenol-chloroform technique. The rs1800470 polymorphism of the TGF-β1 gene was tested using real-time polymerase chain reaction (PCR) (TaqMan probes, AB 7900HT). Assessment of the severity of coronary lesions was carried out initially according to the standard coronary angiography (CAG) protocol with the calculation of the Gensini score. CAG was also conducted in the dynamics after 5-103 months (42,3±29,5 months) of the study beginning.Results. In male carriers of the rs1800470 A allele of the TGF-β1 gene, the mean values of the Gensini score statistically significantly increased (47,5±34,1 (CAG-1) and 64,5±35,5 (CAG-2), p <0,001) in comparison with carriers of the homozygous GG rs1800470 variant of the TGF-β1 gene (43,5±21,1 (CAG-1) and 46,2±23,2 (CAG2), p=0,066). In patients who had rs1800470 A allele of the TGF-β1 gene, a 20%decrease in the Gensini score was observed after 7 months (p=0,013), and 30% — after 5 months (p=0,003) of the initial CAG. The development of late stent restenoses in carriers of the rs1800470 A allele and the homozygous risk genotype AA of the TGF-β1 gene was noted at an earlier date — 8 (p=0,047) and 12 months (p=0,002), respectively.Conclusion. Currently, the conduct of CAG in dynamics in patients undergoing PCI is recommended as clinically indicated. The exception is the group of patients who underwent endoprosthesis replacement of the left coronary artery or have uncorrected stenosis of a different location from 3 to 12 months after PCI. The presented data show a possible predictor role of rG1800470 polymorphism of the TGF-β1 gene in relation to the progression of coronary atherosclerosis and the development of late stent restenoses.
Laws on normative legal acts of the cis countries — indicators of informatization and digitalization processes in the legislation system
Authors: Lipen S. V. 
Published: September 2019

The Russian Federation has not adopted any law regulating normative legal acts, whereas in a number of CIS countries such laws have been in force for almost two decades, and the legal regulation of relations in question is being constantly improved. This experience may well be taken into account in domestic research, including the studies aimed at providing scientific support of the law-making activity. The last quarter of the 20th century is characterized by digitalization and informatization of the legal system; laws on normative legal acts of the CIS countries can serve as quite good indicators of these processes. They demonstrate modern trends in the development of legislation with due regard to the information capabilities of the Internet, information and reference systems. Computer technologies are actively used to represent legislation in electronic form (register, data bank, including Internet resource), to promulgate and bring into legal force normative legal acts, to provide access to the current legislation (including publication of adopted normative legal acts in unofficial information and reference systems, on websites of state bodies, non-governmental organizations) in activities aimed at systematizing legislation. Comparative legal characteristics of the legislation of the CIS countries may well be in demand during the development and discussion of the draft Russian Law on normative legal acts.
Judicial practice in cases of termination of the right subsoil use in conjunction with the rights to land, forest plots, water bodies (integrated approach)
Authors: Kurnitskaya A. V. 
Published: September 2019

The paper discusses the mechanisms for terminating the right to use subsoil in order to protect the environment.From the point of view of environmental protection, the problem of leaving a subsurface user with unreserved and (or) illiquid unclaimed and unsuitable wells for development is analyzed.The cases of suspension, termination of the right of subsoil use are investigated, including those in the absence of formalized rights to land, forest plots, water bodies. Taking into account the experience of judicial practice, the means of protecting public interest aimed at preserving environmental components are evaluated. The author makes conclusions about establishing, among essential conditions, a license for the use of subsoil resources to conclude a lease contract for land and forest plots, and to obtain a decision on the provision of a water body before starting work and about the termination of the title right to use the corresponding land, forest plot, water body upon termination of the right to use subsoil.
ECONOMIC THEORY OF CLUSTER DEVELOPMENT OF A REGION WITH A HIGH VALUE OF PETROCHEMICAL COMPLEX
Authors: I.L. Beilin 
Published: September 2019

Purpose: The purpose of this study is to develop the theory of regional economics in the context of the cluster organization of its petrochemical complex.
Methodology: The research methodology includes the use of cluster analysis and network planning of performance indicators of the petrochemical complex of the Republic of Tatarstan.
Findings: It was found that over seven years of the existence of petrochemical cluster in the Republic of Tatarstan, no synergistic effects were achieved because of its activities. At the same time, significant financial resources were allocated to the cluster organization of petrochemical complex in this region and an administrative apparatus was created. The very concept of cluster development of the region in science and practice has long proved its viability in many countries, such as the Republic of Tatarstan since Michael Porter. This is because the Soviet times is provided with a highly developed industrial base and inexpensive labor in the field of petrochemical technologies, and the training of professional specialists in the region is provided by a concentration of higher education institutions.
Implications: The economic and mathematical approaches used in this study enable it to single out the forms of activity in the cluster that enable it to increase its efficiency to the greatest extent with the least costs. Comprehensive network planning of cluster innovation based on graphical and potential methods presented in the study provide competitive advantages to small- and medium-sized companies.
SCHOOL PROBLEMS IN THE EDUCATION AND DEVELOPMENT OF GIFTED CHILDREN: PSYCHOLOGICAL ASPECT
Authors: Gali Gulnara F. , Fakhrutdinov Bulat I. , Shakhnina Irina Z. , Zagladina Elena N. 
Published: September 2019

Purpose of the Study: The urgency of the problem under investigation is because, the issue of gifted students’ education is one of the most difficult and interesting aspects of contemporary pedagogy. The purpose of the article is to identify the psychological characteristics of the gifted students’ development. In this article, the school difficulties of gifted students are revealed and the causes of internal and external nature are analyzed.
Methodology: The leading approach to the study of this problem is a method of a theoretical analysis and synthesis of social, political, and psycho-pedagogical literature.
Results: The main result of the study is a theoretical analysis of the relationship between learning and the development of gifted children and their psychological characteristics.
Application:The materials of the article can be useful for teachers, students, and a wide range of readers interested in the problems of gifted students’ education. The authors pay special attention to the social and emotional consequences, which can be rather destructive if appropriate assistance is not provided by teachers, psychologists, and parents.
In canine cranial cruciate ligament rupture is outcome following TPLO improved compared with lateral suture?
Authors: Pennington Catrina , Morton Mark , Walton Ben 
Published: September 2019

PICO question
In dogs over 15 kg, with cranial cruciate ligament rupture is there evidence of improved outcome following tibial plateau levelling osteotomy or lateral fabellotibial suture?
Clinical bottom line
Although the evidence is not conclusive, the literature reviewed here suggests that tibial plateau levelling osteotomy (TPLO) results in superior limb function and owner satisfaction compared to placement of a lateral fabellotibial suture (LFS).
There is currently insufficient evidence to determine if there is a difference in complication rates or osteoarthritis (OA) development following TPLO or LFS.
Pola Komunikasi Organisasi Dalam Pengembangan Program Studi Ilmu Komunikasi Fakultas Ilmu Sosial Dan Ilmu Politik Universitas Islam Negeri Raden Fatah Palembang
Authors: Rahmadini Mutia 
Published: September 2019

Communication in organization is very necessary. Because if the organization without good communication, then the common goal will not be achieved. So that’s why, the effective and efficient communication systems are needed. Communication is not only can be done through verbal, but it also can be done through the writing. Based on the context above, the purpose of this research is to answer the question of how the Communications System of Organization in the development of Communication Studies at Faculty of Social and Politic Science, Raden Fatah Islamic State University . The methodology used in this research is descriptive, with qualitative approach. The theory for this research is using organizational information theory from karl Weick. The researcher will do observation, interview, guidelines, and documentation. Data collection techniques are primary data and secondary data. The data collection technique in this research is using primary data in the form of interview data from informants that were considered relevant and become the main source in this reserch, then secondary data that use official records such as documentations, books, etc. Data reduction, data presentation, and conclusions is used for data analysis techniques. The theory used is organization information. System is the absolute form (structure). Communication is a message delivered from the communicator to the communicant through verbal or writings then the occurrence of feedback. Organizations are a number of individuals organized to achieved certain goals. The organizational communication system used by Communication Study Program is a star pattern. Communication is carried out by not only work hour, but also the familiarity outside woring hoursthey do. The media which are used such as whatsapp, email, instagram, telephone, or in person. Barriers that occur are the lack of employess in updating information through online media, language, and distances. Communicaton between the employees occur in openness and good relationships are established. Communication that occurs is very positive. All stakeholders in the Communication Study Program, Faculty of Social and Politic Science are very open with staffs, lectures, and students.
Critical Assessment of the Contemporary Orthopaedic Surgery Residency Application Process
Authors: Li Neill Y. , Gruppuso Philip A. , Kalagara Saisanjana , Eltorai Adam E.M. , DePasse J. Mason , Daniels Alan H. 
Published: September 2019

Background:
Matching into orthopaedic surgery residency in the United States has become an increasingly competitive process because of the large number of well-qualified applicants. Over the past several years, applicants have sought to maximize their chances of matching by submitting an increasing number of applications. The purpose of this study was to assess trends in application numbers, applicant qualifications, and application reviews, with the goal of obtaining data to help inform future improvements in the orthopaedic surgery residency application process.

Methods:
Applicant data were obtained from the Electronic Residency Application Service (ERAS, www.aamc.org/services/eras/stats) and the National Resident Matching Program (NRMP, www.nrmp.org/report-archives). These included residency application data from 2000 to 2017. In addition, we analyzed available NRMP Applicant Survey Reports between 2008 and 2017, Program Director Survey Reports between 2008 and 2016, and NRMP’s Charting Outcomes in the Match between 2006 and 2016.

Results:
The number of U.S. senior medical student applicants per orthopaedic surgery residency position was stable from 2000 to 2017 (1.13 vs. 1.16 for 2000 and 2017, respectively). A significant increase in the United States Medical Licensing Examination (USMLE) Step-1 and Step-2 scores and self-reported research activity was present over the same time period. The number of applications submitted per applicant significantly increased, by 71.7%, from 48.4 in 2006 to 83.1 in 2017. Additionally, applications per program increased 46.4% from 457 in 2010 to 669 in 2016. In 2010, programs performed in-depth reviews for 54% of applications; however, in 2016, in-depth reviews had decreased to 45% of applications.

Conclusions:
Orthopaedic residency applicant USMLE scores and research productivity have increased over time. Concurrently, the average number of applications submitted per applicant has increased, with the average applicant applying to nearly half of all orthopaedic residency programs. Consequently, programs have seen more than double the number of applications over this study period. The accompanying decline in the proportion of applications undergoing in-depth review, along with the applicant and program resources associated with these changes, warrants the development of strategies to enhance the efficiency of the application process for orthopaedic residency.
Establishing a canine brain and tissue bank – molecular validation by RT-qPCR targeting three reference genes
Authors: Sándor Sára , Tátrai Kitti , Czeibert Kálmán , Kubinyi Enikő 
Published: September 2019

Abstract
Background: Dogs ( Canis familiaris ) are natural models of several human diseases, including age-related dementia. However, the molecular techniques, which are routinely applied in invertebrate and rodent models to study disease pathologies and mechanisms, has limited applicability in dogs, mainly because of ethical reasons. In the case of humans, the limited accessibility of tissue samples is at least partly solved by biobanks, which collect and store tissues and organs from voluntary donations. A similar approach with pet dogs could support both translational and veterinary research goals by providing access to good quality biological materials obtained from a wide range of dogs with known ancestry, life history and medical background. Therefore, we have established an initiative, the Canine Brain and Tissue Bank, to collect and store biological samples from pet dogs. Objectives: The molecular qualities of tissue samples collected and stored on a tissue bank are crucial for reliable downstream applications. We used quantitative Real-Time PCR methodology to assess the stability of mRNA content in our stored samples. Three previously validated reference genes, GAPDH , HMBS and HPRT1 were chosen as targets. Results: The tested reference genes showed expression patterns and stability values that were consistent with the literature. Conclusions: Based on the results, the molecular quality of tissues collected in the CBTB’s donations system can fit in the standards of dog gene expression analyses.
Prevalence of objectively measured movement asymmetry in yearling Standardbred trotters
Authors: Kallerud Anne Selven , Fjordbakk Cathrine T. , Hendrickson Eli H. S. , Persson-Sjodin Emma , Hammarberg Marie , Rhodin Marie , Hernlund Elin 
Published: September 2019

Abstract
Background Objective measurement of movement asymmetry is gaining in popularity, especially as an adjunct to traditional lameness evaluation. Earlier research has highlighted the need for more knowledge regarding the clinical significance of measured movement asymmetry, and the influence of biological variation. Evaluating the locomotor system of the Standardbred trotter can be challenging, and studies using objective technology on this breed are few. The aim of this study was to quantify the prevalence and magnitude of objectively measured movement asymmetry in young, presumed sound Standardbred trotters, by performing objective movement analysis during in-hand trot and while driven on a track. Our hypothesis was that asymmetry scores would be higher when evaluating horses in-hand versus while driving on a track.Results Of 103 horses included in the study, 77 were measured both in-hand and on the track, 24 were measured only in-hand, and two were measured only on the track. Previously set symmetry thresholds for the measurement system were used, during both in-hand and track trials. The majority of horses (91, 88.3%) did not have any trials below threshold. Front and/or hind limb parameters were above the symmetry thresholds during in-hand trials for 94 (93.1%) horses, and during track trials for 74 (93.7%) horses. For the total 180 in-hand and track trials, 166 (92.2%) trials were above threshold. Asymmetry magnitude ranged from mild to severe, with the majority of horses showing mild asymmetry. A minority of horses (19.7%) switched side of asymmetry for one or more parameters between in-hand and track trials. Trial standard deviations were overall high, mainly due to horse behavior, and this variability should be considered when interpreting the results. There was no significant effect on asymmetry of measuring horses in-hand versus driven.Conclusions A high proportion of presumed sound Standardbred yearlings showed movement asymmetries above previously determined thresholds. The biological and clinical relevance of the study findings may be aided by examining how this asymmetry evolves over time and with training. This is important in order to ensure the welfare of the Standardbred trotter.
Alzheimer’s Disease and Related Dementias: A Qualitative Assessment of Perceived Training Needs of Primary Healthcare Providers in Rural Southwestern Uganda
Authors: Atuhaire Clara Decent , Obua Celestino , Rukundo Godfrey Z. , Haberer Jessica E. , Wakida Edith K. 
Published: September 2019

Abstract
Background: Alzheimer’s disease and related dementias (ADRD)are the third leading cause of years lived with disability, yet patients presenting with ADRD rarely receive proper care at primary healthcare centres (PHC). PHC providers are expected to be at the frontline of ADRD care and are often the first point of contact for patients with concerns about cognitive function; however, PHC providers may not have the knowledge and skills required to deliver person-centred care to patients. We therefore sought to identify the perceived training needs of PHC providers in recognizing, managing, and referring people with ADRD.
Methodology: This was a cross-sectional qualitative study that was conducted in four districts in south western Uganda (Mbarara, Isingiro, Rukungiri, and Kabale). A semi-structured interview guide based on the WHO guide (toolkit) for community-based management and care of people with dementia was used to collect data from PHC providers (medical officers, clinical officers, nurses and midwives)districts.
Results: The key training needs identified included awareness about ADRD among the PHC providers, knowledge on how to recognise, diagnose, manage and refer people with ADRD and in-service continuous medical education for ADRD, which would in turn lead to improved PHC providers’ attitude towards elderly people with ADRD.
Discussion:Results from the study show a lack of knowledge and inability to identify, diagnose and care for people with ADRD by PHC providers at HC III and HC IVs in rural South Western Uganda. However, The Kyoto Declaration of Alzheimer´s Disease International (ADI) provides sufficient guidelines for streamlining dementia care in the primary healthcare system in low- and middle-income countries, which can be operationalized using the WHO toolkit.
Conclusion: The lack of knowledge by PHCPs in rural south-western Uganda in identifying and managing persons with ADRD is an indication of the need to provide in-service training to improve the identification and management and sensitization of patients with signs of dementia.
Key words: Alzheimer’s disease, dementia, training needs, primary healthcare providers
Skin transcriptome analysis of the genes involved in mucous immunity and discovery of SSRs and SNPs in Crucian carp Carassius auratus
Authors: wang ruixia , Hu Xiucai , lv aijun , Sun Jingfeng , Song Yajiao 
Published: September 2019

Abstract
Fish skin is first line of defence against attachment and penetration of pathogens. Crucian carp (Carassius auratus) is one of the major freshwater species and important food fish in China, yet its molecular mechanism of skin immune response remains unclear. In this study, a de novo transcriptome assembly of crucian carp skin was performed by using Illumina Hiseq 2000 platform. A total of 49,154,776 unigenes were assembled, among which 60,824 (25.16%) unigenes were annotated against the NCBI database. Gene ontology and KEGG mapping assigned the terms to 37,103 (39.15%), 9,337 (23.23%) unigenes, repectively. The best represented KEGG categories were immune system (8,871, 20.50%) and signal transduction (7,805, 18.04%), and several mucin proteins (MUC1, MUC2, MUC5B, MUC5AC, MUC18, etc.) as the main membrane-bound and secreted components of the mucosal layer, implying the differentiation of immune responses in the crucian carp skin. Moreover, the results revealed that potential 28,928 SSRs and 249,964 SNPs were detected in crucian carp. This is the first report on transcriptome analysis in the skin of C. auratus, which contribute to understanding the molecular mechanisms of mucous immunogenectics response and epidermal mucus secretion of the skin in fish.