bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Characterization of Thermoresponsive Double‐Network Nanocomposite Hydrogel for Bone Tissue Engineering
Authors: Indurkar Abhishek , Rubenis Kristaps , Boccaccini Aldo R. , Locs Janis 
Published: November 2024

AbstractIn this study, a thermoresponsive double‐network (DN) nanocomposite hydrogel is developed. The primary hydrogel network comprises Pluronic P123, while the secondary network comprises gelatinmethacrylate (GELMA) and polyacrylamide (PAM). A systematic approach is adopted to develop DN hydrogels. Initially, the impact of Pluronic P123 concentrationon the mechanical properties of PAM‐GELMA hydrogel is investigated. Results from the tensile strength and the oscillatory shear tests reveal that an increasing P123 concentration has a marginal effect on the storage modulus while significantly reducing the loss modulus of the PAM‐GELMA hydrogel, thereby improving mechanical properties. Notably, DN3 hydrogel containing 7.5w/v% P123 in PAM‐GELMA exhibits osteoid matrix‐like mechanical properties. To further enhance the mechanical properties, citrate‐containing amorphous calcium phosphate (ACP_CIT) is incorporated in DN3 hydrogel at varying concentrations. At a lower concentration of ACP_CIT (0.75 w/v%), the mechanical properties of DN3‐ACP0.75 hydrogel are notably enhanced. Incorporating ACP_CIT in DN3 hydrogel (DN3‐ACP0.75) decreases creep strain, rapid stress relaxation, and reduced water uptake capacity while maintaining the thermoresponsive behavior. Finally, an in vitro analysis confirms the cytocompatibility of the hydrogels with MC3T3‐E1 cells, indicating the potential use in bone tissue engineering.
Elaboration and Characterization of Different Zirconium Modified ETS Photocatalysts for the Degradation of Crystal Violet and Methylene Blue
Authors: Lazarova Hristina I. , Rusew Rusi I. , Tsvetanova Liliya V. , Barbov Borislav Z. , Tacheva Elena S. , Shivachev Boris L. 
Published: November 2024

AbstractIn this study, Zirconium‐modified Engelhard Titanium Silicate 4 (Na−K‐ETS‐4/xZr) catalysts were synthesized and evaluated for their photocatalytic efficiency in degrading crystal violet (CV) and methylene blue (MB) in aqueous solutions. The catalysts were characterized using XRD, FTIR, SEM, WDXRF, and nitrogen adsorption/desorption isotherms. The results confirmed the successful incorporation of Zr into the ETS‐4 framework, with the highest Zr content reaching 9.2 wt %. The photocatalytic performance under visible light irradiation was studied at varying pH levels. The Na−K‐ETS‐4/6.3Zr catalyst exhibited the highest photodegradation efficiency for CV (76.6 %), while Na−K‐ETS‐4/8.9Zr achieved 86.6 % efficiency for MB. A combination of Engelhard Titanium Silicate 10, Na−K‐ETS‐10/6.3Zr and Na−K‐ETS‐4/8.9Zr significantly enhanced dye degradation, achieving up to 96.5 % efficiency for MB. Kinetic studies indicated that the degradation process follows a non‐linear pseudo‐first‐order model. The catalysts also demonstrated excellent reusability, with minimal efficiency loss after five cycles, and full recovery after an ethanol wash. These findings suggest that Na−K‐ETS‐4/xZr is a promising candidate for environmental water treatment applications due to its efficient photodegradation performance and stability.
Exploring the Role of Herbal Compounds in Skin Aging: A Systematic Review of Topical Approaches
Authors: Goh Asly Poh‐Tze , Goh She‐May , Tow Wai‐Kit , Toh Kar‐Men , Palanisamy Uma Devi , Sundralingam Usha 
Published: November 2024

ABSTRACTRecently, dermatology has increasingly focused on understanding skin aging and exploring novel therapeutic approaches. Despite progress in cosmetic and pharmaceutical research, a significant gap remains in comprehensively understanding the effects and mechanisms of herbal extracts on skin aging. While many studies have examined the bioactivities of herbal compounds in preclinical models, comprehensive human trials have been scarce over the past decade. This review aims to address this gap by synthesizing human trials from the past decade, focusing on the therapeutic effects of herbal extracts on skin aging. The objective is to unravel the mechanisms contributing to skin aging and assess the therapeutic potential of herbal compounds. Following the PRISMA 2020 guideline, a systematic review was performed across OvidMEDLINE, Cochrane Central Register of Controlled Trials, and Embase via Ovid. A meticulous search strategy identified relevant clinical trials. The review highlights the essential role of herbal compounds in skin aging, particularly their antioxidant activity in suppressing the aging process. Analysis of 51 clinical trials offers valuable insights into their diverse effects on skin aging parameters. Herbal compounds are promising alternatives to synthetic products for treating skin aging. Their demonstrated efficacy in mitigating wrinkles, enhancing elasticity, maintaining hydration, and controlling pigmentation underscores their potential in developing antiaging therapeutics. However, further studies are needed to identify specific compounds responsible for these effects and understand their mechanisms. Future directions include conducting large‐scale trials, exploring synergies with other ingredients, and optimizing delivery systems for sustainable, effective antiaging therapies.
Perspectives, Experiences, and Practices of Healthcare Professionals and Patients Towards Herb–Drug Interaction: A Systematic Review of Qualitative Studies
Authors: Shen Chen , Ren Zhi‐Ying , Lan Hui‐Di , Kong Ling‐Yao , Yang Ming , Su You‐Zhu , Yue Xiao‐Lei , Wan Zu‐Lin , Xiao Li‐Xue , Chen Pi‐Pi , Li Xun , Zhou Xian , Robinson Nicola , Liu Jian‐Ping 
Published: November 2024

ABSTRACTThe aim of the study was to understand healthcare professionals, pharmacists, and patients perspectives and experiences on clinical practice of herb–drug interactions (HDIs). A systematic review of qualitative studies was conduct. 10 electronic databases were searched from inception through September 2023. Qualitative studies, mixed‐method studies, and unstructured or semi‐structured cross‐sectional surveys focused on healthcare professionals, pharmacists and patients' perspectives, attitudes, clinical practice behaviors, and information needs regarding HDI were included. Thematic synthesis employed Nvivo 12 software. Of 6655 studies identified, 1267 full‐text articles were retrieved. Of these, 18 studies conducted in 11 countries/regions were eligible for inclusion, involving 1273 patients, 302 healthcare professionals, and 230 pharmacists. Five over‐arching explanatory themes were identified: perspectives, attitudes, practices, experiences, expectations, and information needs. Complementary and alternative (CAM) physicians, pharmacists, and general practitioners were considered by patients to possess the ability or responsibility to assess potential HDIs. Pharmacists yet encountered difficulties due to conflicting information sources and inadequate training. Healthcare professionals, including pharmacists, usually only assessed HDIs when they were deemed to cause serious adverse effects. Regarding expectations and information needs, patients were particularly concerned about the risk of adverse HDIs, the severity of HDIs, and the appropriate intervals between drug doses. They would like to receive relevant HDI alerts. Results suggest that government, policy makers, healthcare professionals, and the education system should give attention to HDIs and improve health professional—patient communication. Further research should also be conducted on the understanding and practices of CAM practitioners in China.
Trial Registration: CRD42022324777 (https://www.crd.york.ac.uk/PROSPERO/#recordDetails)
Update on Pharmacological Drugs and Macrocyclic Compounds as Corrosion Inhibitors
Authors: Rani Anjali , Aslam Mohd. , Nand Bhaskara , Pandey Garima , Singh Prashant 
Published: November 2024

AbstractCorrosion of metals and alloys is a critical challenge across various industries, leading to substantial financial losses and safety risks. The use of corrosion inhibitors has proven to be an effective strategy in mitigating this issue. This review provides a comprehensive overview of the latest advancements in the use of macrocyclic compounds and pharmacological drugs as corrosion inhibitors. These compounds exhibit unique chemical structures and functional groups, which enhance their ability to improve corrosion resistance through adsorption onto metal surfaces, thereby reducing oxidation and electrochemical reactions. The review highlights the effectiveness of these inhibitors in diverse corrosive environments and their compatibility with different metals and alloys, including steel, aluminum, and copper. Key findings reveal their superior performance in creating protective barriers and their potential for offering more sustainable, eco‐friendly solutions compared to conventional inhibitors. This review emphasizes their inhibitory effects, investigates their underlying mechanisms, and underscores the importance of ongoing research and innovation to maximize their use as effective and sustainable corrosion prevention techniques.
Partial Selenization Strategy for Fabrication of Ni0.85Se@NiCr‐LDH Heterostructure as an Efficient Bifunctional Electrocatalyst for Overall Water Splitting
Authors: Nitika  , Dutta R.K. 
Published: November 2024

AbstractNiCr‐LDH and its partial selenization as Ni0.85Se@NiCr‐LDH heterostructure is established here as an alkaline water electrolyzer for achieving enhanced overall water splitting efficiency. The hydrothermally synthesized optimized batch of Ni0.85Se@NiCr‐LDH is thoroughly characterized to elucidate its structure, morphology, and composition. Compared to pristine NiCr‐LDH, the batch of Ni0.85Se@NiCr‐LDH exhibits exceptional alkaline OER and HER activity with low overpotentials of 258 and 85 mV at 10 mA cm−2, respectively. Besides, Ni0.85Se@NiCr‐LDH also exhibits excellent acidic HER with an overpotential of only 61 mV at 10 mA cm−2, indicating that Ni0.85Se@NiCr‐LDH can operate effectively across a wide pH range. The excellent electrochemical stability of Ni0.85Se@NiCr‐LDH for 24 h operation is attributed to the formation of a thin layer of SeOx during OER operation. The role of selenization and the effect of Cr in the LDH lattice toward enhanced electrocatalytic water splitting is discussed. The outstanding OER and HER performances of Ni0.85Se@NiCr‐LDH are attributed to the higher electrochemical active surface area, favorable conditions for adsorption of HER/OER intermediates, low charge transfer resistance, and improved conductivity. The practical application of Ni0.85Se@NiCr‐LDH as a bifunctional electrocatalyst for overall water splitting is reflected from the low cell voltage of 1.548 V at 10 mA cm−2.
Large‐Current CO2 Electromethanation Through Active Hydrogen Regulation Over Carbon Nitride
Authors: Yan Tianxiang , Jin Yaxin , Fan Qun , Liu Hai , Li Xindi , Zhang Tianying , Wang Hui , Lin Jianlong , Chi Haoyuan , Zhang Sheng , Ma Xinbin 
Published: November 2024

AbstractElectromethanation of CO2 has received intensive attention due to its high calorific value and convenient storage along with transportation to accommodate industrial demands. However, it is limited by sluggish multi‐step proton‐coupled electron transfer kinetics and undesired *H coupling under high current density, posing great challenges to its commercialization. Herein, carbon nitride (CN) with superior hydrogen adsorption ability is used as an active‐hydrogen adsorption and supply material. Through a facile liquid‐assisted exfoliation and electrostatic self‐assembly strategy to strengthen its interfacial contacts with Cu2O catalysts, yielding a strengthened CH4 production 52 times higher than that of pristine Cu2O. Flow‐cell test ultimately achieved FECH4 and remarkably CH4 partial current density of 61% and 561 mA cm−2, respectively. With in situ ATR‐FTIR spectra and DFT calculations, it is established that strengthened interfaces enabled abundant *H tethered by ─C─N═C─ sites in CN nanosheets and oriented to the *CO hydrogenation to *CHO and *CHx on Cu species. This work reveals the profound influence of fine‐expanded interfaces with dimensional materials on the product distribution and yield through the active‐hydrogen management, which is of reference value for other small‐molecule electro‐polarization dominated by the proton‐coupled electron transfer (PCET) process (e.g., N2, O2, etc.).
Determination of Polycyclic Aromatic Hydrocarbons in Water Samples Using Solid‐Phase Extraction Procedure and High‐Performance Liquid Chromatography With Fluorescence Detection
Authors: Ghanmi Safouane , Hassine Sihem Ben , Bouabdallah Sondes , Driss Mohamed Ridha , Touil Soufiane 
Published: November 2024

ABSTRACTSolid phase extraction (SPE) procedure followed by high‐performance liquid chromatography with fluorescence detection was evaluated for determination of 14 priority polycyclic aromatic hydrocarbons (PAHs) pollutants in water samples. Diverse parameters affecting extraction efficiency such as the nature and volume of eluent solvent, volume and pH of the water sample, and quantity and nature of sorbent phase were studied and optimized. SPE was carried out on Bond Elut C18 cartridge and high recoveries were obtained using 1000 mg of the sorbent for the treatment of a 500 mL water sample. PAH recoveries ranged from 60.3% to 93.3% for 500 mL treated water samples. The developed method gives very low detection limits ranging between 0.03 and 12 ng/mL and it has been applied successfully to different environmental water samples such as tap water, mineral water, surface water, treated wastewater, and industrial effluents. Results showed the presence of PAHs especially in industrial effluent from the Bizerte region with ∑PAHs means value of 33.76 mg/L and in treated wastewater samples collected from North Tunisia with ∑PAHs concentrations levels of 0.81, 1.17, 0.97, and 0.72 mg/L in Bizerte, Tunis, Ben Arous, and Beja wastewater treatment plants, respectively.
Diversification of fescues (Festuca sect. Eskia, Poaceae), a key‐component of southern European mountainous grasslands
Authors: Mucko Maja , Lakušić Dmitar , Frajman Božo , Bogdanović Sandro , Doboš Marko , Ljubičić Ivica , Kuzmanović Nevena , Rešetnik Ivana 
Published: November 2024

AbstractGrasslands cover approximately 30% of all land area and represent one of the most extensive and diverse ecosystems of the world. One of the largest globally distributed genera dominating various types of grasslands is Festuca (Loliinae, Poaceae). In this study, we disentangle the origin and diversification of early divergent lineages within fine‐leaved (FL) Loliinae, namely F. sect. Eskia and F. sect. Dimorphae (Eskia‐Dimorpha Group). We inferred phylogenetic relationships among 218 populations of 129 Loliinae taxa using nuclear ribosomal ITS and plastid trnT‐trnF sequences. Relative genome size (RGS) and ploidy level estimations revealed multiple polyploidisations within F. sect. Eskia. We uncovered previously unknown tetraploid and hexaploid populations of different species from the Balkan Peninsula. The inferred phylogenies revealed the sequential divergence of Eskia‐Dimorpha Group lineages in the early evolution of FL Loliinae, but also incongruences in the position as well as the composition of different clades between the nuclear and plastid‐based trees. Despite incongruences, some well‐supported and geographically segregated clades of single or closely related species from the Alps, the Pyrenees or the Balkan Peninsula were resolved. The most pronounced discordance between the plastid and nuclear data were among several taxa endemic to the Balkan Peninsula. Our data suggest that genome downsizing followed polyploidisation and that evolutionary dynamics of RGS‐ups and downs within F. sect. Eskia were strongly phylogenetically correlated. Overall, our study underscores the intricate evolutionary history and differentiation of species within the Eskia‐Dimorpha Group, emphasizing the need for further research to refine phylogenetic hypotheses and taxonomic circumscriptions, thereby enhancing our understanding of grassland biodiversity and evolution.
Advocacy‐oriented language teacher educator identity as ethical self‐formation: A polyvocal exploration
Authors: Warren Amber N. , Ward Natalia A. , Çermikli Ayvaz Başak , Dias Maria José A. , Linville Heather A. , Whiting James 
Published: November 2024

AbstractLanguage teacher educators’ identity is a significant contributor to pedagogical and professional choices they make in their work. Utilizing Foucault's notion of ethico‐political self‐formation as adapted by Clarke (2009), the researchers explored the identities of six advocacy‐oriented language teacher educators (LTEs) working in the United States. In their polyvocal exploration, they focus on the ethical substance, authority sources, and self‐practices that contribute to the formation of advocacy‐oriented professional identities. Analysis revealed interactions between prior experiences, relationships, key theories, and self‐practices of reflection as formative to identities as advocacy‐oriented LTEs. The researchers discuss their findings in light of the relationship of identity formation to pedagogy and what collaborative self‐reflection reveals about the formation of an advocacy‐oriented LTE identity. The findings contribute to our developing understanding of advocacy within the context of language teaching and language teacher education.
Heterogeneity of definition of upper gastrointestinal tract in different guidelines of Crohn's disease: A scoping review
Authors: Yuan Yuhong , Sedano Rocio , Solitano Virginia , Nardone Olga Maria , Crowley Eileen , Jairath Vipul 
Published: November 2024

AbstractCrohn's Disease (CD) can affect any part of the gastrointestinal (GI) tract, including the upper GI tract (UGIT). However, the definitions and classifications of upper GI CD (UGICD) vary. We conducted a scoping review to explore how UGIT and UGICD are defined and to assess the heterogeneity of these definitions in published CD guidelines, aiming to inform future initiatives for harmonizing definitions. We conducted a search of MEDLINE and Embase for English‐language guidelines on CD that mentioned upper GI‐related terms in the titles, abstracts, or keywords from inception until 26 July 2024. Definitions of UGIT and UGICD were summarized descriptively. Of 1132 citations, only 19 records met our inclusion criteria. Only eight were identified as CD guidelines. None of them focuses on UGICD. Among these, five diagnostic guidelines explicitly mentioned “upper GI” in their abstracts. Only the joint European Crohn's and Colitis Organisation and European Society of Gastrointestinal and Abdominal Radiology guidelines clearly defined the UGIT. Most guidelines mentioned UGI terms related to upper endoscopy or biopsy only. It was unclear whether these guidelines typically included the esophagus, stomach, and duodenum in the definition of UGICD while excluding the distal small intestine. Although the latest guideline related to pediatric‐onset IBD cited the 2011 Paris classification, none of the three guidelines published after that explicitly mentioned the proposed subdivided location of the upper disease. There is a lack of consistent reporting in defining UGICD according to disease location. It is unclear whether there is a consensus on excluding the small intestine beyond the duodenum. Additionally, there is no indication that the subdivided location of UGIT was considered in CD guideline development. Greater consistency in definitions would aid in diagnosis, clinical care, epidemiological research and inclusion into clinical trials. These findings underscore the need for developing a framework to standardize the classification of UGICD, especially for clinical trials.
Organoid‐based precision medicine in pancreatic cancer
Authors: Beutel Alica K. , Ekizce Menar , Ettrich Thomas J. , Seufferlein Thomas , Lindenmayer Jessica , Gout Johann , Kleger Alexander 
Published: November 2024

AbstractPancreatic ductal adenocarcinoma (PDAC) ranks among the leading causes of cancer‐related deaths worldwide. Despite advances in precision oncology in other malignancies, treatment of PDAC still largely relies on conventional chemotherapy. Given the dismal prognosis and heterogeneity in PDAC, there is an urgent need for personalized therapeutic strategies to improve treatment response. Organoids, generated from patients' tumor tissue, have emerged as a powerful tool in cancer research. These three‐dimensional models faithfully recapitulate the morphological and genetic features of the parental tumor and retain patient‐specific heterogeneity. This review summarizes existing precision oncology approaches in PDAC, explores current applications and limitations of organoid cultures in personalized medicine, details preclinical studies correlating in vitro organoid prediction and patient treatment response, and provides an overview of ongoing organoid‐based clinical trials.
Tremors in cats with hepatic encephalopathy‐congenital portosystemic shunts or postattenuation neurological syndrome
Authors: Liatis Theofanis , Bhatti Sofie F. M. , Glanemann Barbara , De Decker Steven 
Published: November 2024

AbstractBackgroundTremors have been reported as a neurological sign in cats with hepatic encephalopathy due to congenital portosystemic shunts (HE‐CPSS) or postattenuation neurological syndrome (PANS).MethodsThe clinical records of cats diagnosed with HE‐CPSS and manifesting tremors between 2003 and 2023 were retrospectively reviewed to characterise the clinical features of the tremors.ResultsNineteen cats with HE‐CPSS were included, of which 17 manifested tremors at admission and two had PANS. Domestic shorthair was the most common breed (12/19). Tremors were the only neurological sign in six of the 19 cats. Tremor localisation was generalised (10/19) or focal to the head (8/19) or a limb (1/19). Most tremors were episodic and non‐intentional (15/19), occurring usually at rest with occasional intentional features (4/19). Of the 14 cats for which 1‐month follow‐up was available, tremors discontinued in nine after surgical or medical management.LimitationsThe limitations of this study included its retrospective nature and the lack of video recordings, brain magnetic resonance imaging and electrophysiological evaluation of tremors in all cases.ConclusionsA diagnosis of HE‐CPSS or PANS should be considered in cats with generalised or focal tremors.