bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic analysis of Tianzhu White Yak (Bos grunniens) testis at different sexual developmental stages
Authors: Ruan Chong‐Mei , Wang Jing , Yang Yong‐Xin , Hu Jun‐Jie , Ma You‐Ji , Zhang Yong , Zhao Xing‐Xu 
Published: January 2019

AbstractTo explore the protein expression profiles of white yak (Bos grunniens) testis at different sexual developmental stages. The protein profiles of yak testis were determined using two‐dimensional electrophoresis and the expression levels of 298 protein spots were analyzed. Mass spectrometry was performed to identify those significantly differential expressed proteins; Western blotting was used to confirm the results. During the developmental stages, 29 protein spots showed more than twofold differences (p < 0.05) at ≥1 time point and were successfully identified. Two proteins were upregulated with age (category 1), five proteins (17.2%) were downregulated with age (category 2), four proteins were upregulated before 4 years of age and downregulated thereafter (category 3), fifteen proteins were upregulated before 2 years of age and downregulated thereafter (category 4), and three proteins fluctuated with age (category 5). The expression patterns of regucalcin and heat shock 60 kDa protein in category 2 were confirmed. The 29 differentially expressed proteins from yak testes (some had more than one function) were categorized into binding (n = 15), catalytic activity (n = 13), molecular function regulator (n = 4), antioxidant (n = 4), molecular transducer (n = 2), transporter (n = 1), and structural molecule (n = 1). The identification and analysis of these testis proteins may assist in understanding the developmental biology of reproduction system in male yak.
Infant Attachment Insecurity and Baseline Physiological Activity and Physiological Reactivity to Interpersonal Stress: A Meta‐Analytic Review
Authors: Groh Ashley M. , Narayan Angela J. 
Published: January 2019

This meta‐analytic review (k = 5–10; N = 258–895) examined links between attachment insecurity and physiological activity at baseline and in response to interpersonal stress elicited by separation–reunion procedures in the early life course (1–5 years). Insecurity was trivially, nonsignificantly associated with baseline physiological activity (heart rate [HR]: g = −.06; respiratory sinus arrhythmia [RSA]: g = −.06; cortisol: g = .01) and nonsignificantly associated with physiological reactivity to separation from parents (HR: g = −.001; RSA: g = .24). However, insecurity was moderately associated with heightened RSA (g = .26) and cortisol (g = .27) reactivity upon reunion with parents. Findings provide insight into the biobehavioral organization of attachment, suggesting that early insecurity is associated with heightened physiological reactivity to interpersonal stress.
Retrospective cohort study comparing endoscopic ultrasound‐guided and percutaneous drainage of upper abdominal abscesses
Authors: Carbajo Ana Yaiza , Brunie Vegas Francisco Javier , García‐Alonso Francisco Javier , Cimavilla Marta , Torres Yuste Raúl , Gil‐Simón Paula , de la Serna‐Higuera Carlos , Fernández Pérez Gabriel Carlos , Pérez‐Miranda Manuel 
Published: January 2019

Background and AimEndoscopic ultrasonography (EUS)‐guided drainage (EUS‐D) has become the standard treatment for peripancreatic fluid collections. Its use in other intra‐abdominal abscesses has been reported, although there is limited evidence.MethodsWe carried out a single‐center retrospective cohort study comparing percutaneous drainage (PCD) and EUS‐D of upper abdominal abscesses between January 2012 and June 2017. Pancreatic fluid collections and liver transplant recipients were excluded. Primary endpoints were technical and clinical success rates.ResultsWe included 18 EUS‐D (nine hepatic and nine intraperitoneal abscesses) and 62 PCD. There were no differences regarding age, gender and etiology. Size was larger in the PCD group (80 vs 65.5 mm, P = 0.04) and perivesicular location was more frequent in the PCD group (24.2% vs 11.1%, P = 0.003). In the EUS‐D group, metal stents were deployed in 16 (88.9%) subjects (eight lumen‐apposing metal stents and eight self‐expandable metal stents), coaxial double‐pigtail plastic stents in six (33.3%) and lavage/debridement was carried out in five (27.8%). There were no significant differences in technical success (EUS‐D: 88.9%, PCD: 96.8%, P = 0.22) or clinical success (EUS‐D: 88.9%, PCD: 82.3%, P = 0.50), with no relapses in the EUS‐D group and 10 (16.1%) in the PCD group (P = 0.11). There were four (22.2%) adverse events in the EUS‐D group, none of them severe, and 13 (21%) in the PCD group (P = 0.91).ConclusionsEUS‐D is an alternative to PCD in the treatment of upper abdominal abscesses, reaching similar success, relapse and adverse events rates.
The influence of government ideology on monetary policy: New cross‐country evidence based on dynamic heterogeneous panels
Authors: Giesenow Federico M. , de Haan Jakob 
Published: January 2019

AbstractUsing data of 23 OECD countries over the 1980–2005 period, we examine whether government ideology affects monetary policy, conditional on central bank independence. Unlike previous studies in this line of literature, we estimate central bank behavior using forward‐looking and real‐time data in Taylor rule models and use estimators that allow for heterogeneity across countries. Our models with heterogeneous slope coefficients for the full sample do not suggest partisan effects. We also do not find evidence that central bank behavior is conditioned by the interaction of the ideology of the incumbent government and the electoral calendar.
In silico analysis of the binding properties of solasonine to mortalin and p53, and in vitro pharmacological studies of its apoptotic and cytotoxic effects on human HepG2 and Hep3b hepatocellular carcinoma cells
Authors: Pham Minh Quan , Tran Thi Hoai Van , Pham Quoc Long , Gairin Jean Edouard 
Published: January 2019

AbstractLiver cancer, of which human hepatocellular carcinoma (HCC) is the most common type, represents the second most common cause of death from cancer worldwide. To date, treatments remain mostly ineffective and efforts are made to discover new molecules or therapeutic strategies against HCC. Mortalin, an hsp70 chaperone protein, is overexpressed in various cancer, including HCC. Mortalin sequesters p53 into the cytoplasm, thereby inhibiting its translocation to the nucleus and consequently, its cellular functions. Inhibition of mortalin–p53 interactions, which should activate the apoptotic process and the subsequent cell death, has thus been proposed as an anticancer strategy. In silico screening of a database of 354 natural compounds identified solasonine, a steroidal glycoalkaloid from Solanaceae, as a potent inhibitor of p53–mortalin interactions. Pharmacological studies confirmed that solasonine was able to inhibit efficiently mortalin–p53 interaction in HCC HepG2 cell line that expresses both mortalin and p53. This resulted in p53 translocation to the nucleus. Solasonine‐induced apoptosis and cell death of HCC cell lines either expressing p53 (HepG2) or not (Hep3b), indicating that apoptotic activities of solasonine can be mediated not only through p53‐dependent but also p53‐independent pathways. The cytotoxic effects of solasonine correlated in part with its apoptotic properties and differed in the two HCC cell lines, being reversed by pifithrin‐α, an inhibitor of p53 functions, in HepG2 cells but not in Hep3b cells. Nonapoptotic cell death was also observed, notably in Hep3b cells.
Octopus as predators of abalone on a sea ranch
Authors: Greenwell Claire N. , Loneragan Neil R. , Admiraal Ryan , Tweedley James R. , Wall Mark 
Published: January 2019

AbstractThis study examined the occurrence of octopus across an abalone, Haliotis laevigata, Donovan, sea ranch in south‐western Australia, to understand how octopus may be impacting abalone production. Commercial divers removed 654 octopus and 17,666 empty abalone shells during regular, 2 to 4‐weekly surveys over 27 months. A negative binomial generalised linear model estimated a 78% increase in empty shells per artificial abalone habitat per day, when octopuses were present, after adjusting for location and season. Of the 408 shells examined for evidence of predation, 19% had a small, slightly ovoid hole consistent with those made by octopus. The mean (± 1 SE) length of shells with boreholes (70.3 ± 2.2 mm) was significantly longer than those without (59.8 ± 0.5 mm), and boreholes were concentrated over the adductor, respiratory organs and heart. This study provides important insights into the adaptable feeding regimes of octopus and their potential to impose strong top‐down controls on sea ranching operations.
Dynamics of early life‐history stages of fish along an estuarine gradient
Authors: Santos Régis Vinícius Souza , Severi William 
Published: January 2019

AbstractThis study aimed to identify the spatial and temporal patterns of composition and distribution of early life‐history stages of fish along an estuarine gradient. Samples were collected quarterly between April 2010 and January 2011 using conical‐cylindrical plankton nets in the Vaza Barris estuarine river system (NE Brazil). A total of 38,781 fish eggs and 3,526 larvae, representing 20 families and 42 taxa, were caught. The most abundant larval taxa were Microgobius meeki, Ctenogobius gr. smaragdus/boleosoma, Gobionellus oceanicus, Ctenogobius gr. stigmaticus/saepepallens/shufeldti, Bairdiella ronchus, Achirus sp., Trinectes sp., Stellifer rastrifer and S. stellifer, accounting together for 34.5% of the total catch. Ichthyoplankton distributions were characterized by high seasonal and spatial variability mainly attributed to the environmental characteristics of the estuary. Overall, lower estuarine region served as important accumulation areas for ichthyoplankton, concentrating the greatest diversity and abundance. Salinity gradient, water temperature, and inorganic nutrients were the main variables that affected the larval fish assemblages, presumably influencing spawning, development and survival of individuals or through their effect on food supply. Moreover, this study reinforced the concept that hydrological variations may have a strong influence on estuarine species retention and marine species immigration. Finally, this study highlights the importance of estuaries for the growth and maintenance of stocks of fish species, and the development of strategies to protect these habitats is of utmost relevance.
Sex and racial/ethnic differences in the association between childhood attention‐deficit/hyperactivity disorder symptom subtypes and body mass index in the transition from adolescence to adulthood in the United States
Authors: Inoue Y. , Howard A. G. , Stickley A. , Yazawa A. , Gordon‐Larsen P. 
Published: January 2019

SummaryBackgroundWhile attention‐deficit/hyperactivity disorder (ADHD) has been associated with higher body mass index (BMI), little research has focused on how this association differs by sex or race/ethnicity.ObjectiveTo investigate the association between ADHD and BMI by sex and race/ethnicity (ie, European [EA], African [AA], and Hispanic American [HA]).MethodsData came from the National Longitudinal Survey of Adolescent to Adult Health Waves II to IV (n = 13 332, age: 12‐34 years). On the basis of self‐reported childhood ADHD symptoms between the ages of 5 and 12 years, participants were categorized into: ADHD predominantly hyperactive/impulsive (ADHD‐HI); ADHD predominantly inattentive (ADHD‐I); ADHD combined (ADHD‐C; a combination of ADHD‐HI and ADHD‐I symptoms); and non‐ADHD.ResultsThe patterns of ADHD‐BMI associations in the transition period between adolescence and young adulthood differed by sex and race/ethnicity. Compared with non‐ADHD, ADHD‐HI was associated with higher BMI among EA males and females, while ADHD‐I was associated with higher BMI among EA females. ADHD‐C was associated with higher BMI for HA females. We found no evidence of an association among AA males and females and HA males.ConclusionThese study results suggest that the association between ADHD subtypes and BMI might differ across population subgroups in the United States.
Linking fresh paste microstructure, rheology and extrusion characteristics of cementitious binders for 3D printing
Authors: Nair Sooraj A. O. , Alghamdi Hussam , Arora Aashay , Mehdipour Iman , Sant Gaurav , Neithalath Narayanan 
Published: January 2019

AbstractCementitious binders amenable to extrusion‐based 3D printing are formulated by tailoring the fresh microstructure through the use of fine limestone powder or a combination of limestone powder and microsilica or metakaolin. Mixtures are proportioned with and without a superplasticizer to enable different particle packings at similar printability levels. A simple microstructural parameter, which implicitly accounts for the solid volume and inverse square dependence of particle size on yield stress can be used to select preliminary material combinations for printable binders. The influence of composition/microstructure on the response of pastes to extension or squeezing are also brought out. Extrusion rheology is used in conjunction with a phenomenological model to better understand the properties of significance in extrusion‐based printing of cementitious materials. The extrusion yield stress and die wall slip shear stress extracted from the model enables an understanding of their relationships with the fresh paste microstructure, which are crucial in selecting binders, extrusion geometry, and processing parameters for 3D printing.
Structural, electronic, and dielectric properties of a large random network model of amorphous zeolitic imidazolate frameworks and its analogues
Authors: Wang Hailong , Li Neng , Hu Zhongbo , Bennett Thomas D. , Zhao Xiujian , Ching Wai‐Yim 
Published: January 2019

AbstractThe amorphous zeolitic imidazolate frameworks (a‐ZIFs) models and its analogues (with 918 or 810 atoms, respectively) are constructed based on a larger continuous random network (CRN) model of amorphous SiO2 (a‐SiO2) model. The atomic, electronic, and dielectric properties of these structures, which possess different metal nodes and organic linkers, are investigated by well‐defined density functional theory (DFT) calculations. The results suggest that all a‐ZIFs have ultra‐low dielectric constants and a large energy loss function (ELF), which suggests that they may be good candidates for electromagnetic absorptive materials. Most important, these a‐ZIFs models offer a base‐line model for other amorphous ZIFs for further research on models containing vacancies, defects, doping or under high pressure or high temperature.
Equality of Opportunity in a European Social Market Economy*
Authors: Viehoff Juri 
Published: January 2019

AbstractThis article investigates what role the ideal of equality of opportunity should play in a European social market economy (ESME). After defining ‘social market economy’ and sketching different conceptions of equality of opportunity, it is argued that a social market economy must implement a substantive version of equality of opportunity. Subsequent sections assess how such a robust version needs adaptation in light of the EU's special nature: first, it assesses the merits of a direct transnational application of interpersonal substantive equality. Second, it considers what the ideal requires in a ESME understood along internationalist lines: even on this account, labour mobility creates tensions between EU citizens' claims to equal prospective chances in a fair cross‐border competition against each state's prerogative of providing the highest level of education to its residents. The concluding section offers some suggestions how we might alleviate this tension between domestic equality of opportunity and national autonomy.
Lower body mass index is not of more benefit for diabetic complications
Authors: Zhang Yongze , Guo Yangyang , Shen Ximei , Zhao Fengying , Yan Sunjie 
Published: January 2019

AbstractAims/IntroductionTo investigate the relationship between different body mass index (BMI) levels and vascular complications in type 2 diabetes mellitus patients.Materials and MethodsData were collected from 3,224 individuals with type 2 diabetes mellitus (male/female: 1,635/1,589; age 61.31 ± 11.45 years), using a retrospective case study design. The association of BMI quintiles and diabetes mellitus vascular complications was assessed using multiple logistic regression models adjusting for age, sex, diabetes duration, smoking status, drinking and other confounders, using those with the lowest quintile of BMI as the reference group.ResultsWith increasing BMI, the detection rate of diabetic peripheral neuropathy and peripheral arterial disease initially decreased and then it increased, whereas the detection rate of diabetic kidney disease and carotid atherosclerotic plaques showed an upward trend; however, diabetic retinopathy was irregular. The odds ratios of diabetic peripheral neuropathy decreased as BMI increased from the 21st percentile to the 80th percentile initially, and increased when BMI was in >80th percentile. The same result was shown in peripheral arterial disease. BMI >80th percentile showed a 1.426‐fold risk of diabetic kidney disease and a 1.336 ‐fold risk of carotid atherosclerotic plaque.ConclusionsIn patients with type 2 diabetes mellitus, the relationship between different BMIs and vascular complications varies. A U‐shaped relationship was observed between BMI and diabetic peripheral neuropathy, as well as BMI and peripheral arterial disease. BMI is positively correlated with diabetic kidney disease and carotid atherosclerotic plaque; however, it is not correlated with diabetic retinopathy.
Triglycerides Paradox Among the Oldest Old: “The Lower the Better?”
Authors: Lv Yue‐Bin , Mao Chen , Gao Xiang , Yin Zhao‐Xue , Kraus Virginia Byers , Yuan Jin‐Qiu , Zhang Juan , Luo Jie‐Si , Zeng Yi , Shi Xiao‐Ming 
Published: January 2019

OBJECTIVESCurrently, most treatment guidelines suggest lowering hypertriglyceridemia of any severity, even in elderly individuals. However associations of serum triglycerides (TGs) with adverse health and mortality risk decrease with age, it remains unclear among the oldest old (aged 80 years and older). The study was to investigate the relationship of serum TG concentrations with cognitive function, activities of daily living (ADLs), frailty, and mortality among the oldest old in a prospective cohort study.DESIGNLongitudinal prospective cohort study.SETTINGCommunity‐based setting in longevity areas in China.PARTICIPANTSA total of 930 (mean age = 94.0 years) Chinese oldest old.MEASUREMENTSThe TG concentrations were measured at baseline survey in 2009. Cognitive function, ADLs, frailty, and mortality were determined over 5 years of follow‐up. Cox proportional hazards models and competing risk models were performed to explore the association, adjusting for potential confounders.RESULTSEach 1‐mmol/L increase in TGs was associated with a nearly 20% lower risk of cognitive decline, ADL decline, and frailty aggravation during the 5 years of follow‐up. Consistently, higher TGs (each 1 mmol/L) was associated with lower 5‐year all‐cause mortality after fully adjustment (hazard ratio [HR] = 0.79; 95% confidence interval [CI] = 0.69‐0.89). Nonelevated TG concentrations (less than 2.26 mmol/L) were associated with higher mortality risk (HR = 1.72; 95% CI = 1.22‐2.44), relative to TGs of 2.26 mmol/L or more. We observed similar results regarding TG concentrations and mortality in 1‐year lag analysis and when excluding participants with identified chronic disease.CONCLUSIONIn the oldest old, a higher concentration of TGs was associated with a lower risk of cognitive decline, ADL decline, frailty aggravation, and mortality. This paradox suggests the clinical importance of revisiting the concept of “the lower the better” for the oldest old. J Am Geriatr Soc 67:741–748, 2019.
The effect of various primers improving adhesiveness of gel polish hybrids on pH, TOWL and overall nail plates condition
Authors: Batory Mirella , Wołowiec‐Korecka Emilia , Rotsztejn Helena 
Published: January 2019

SummaryBackgroundHybrid manicure is now a popular method of nail care and nail art, which is associated with its durability. Unfortunately, it has an adverse effect on pH, TOWL and overall nail plates condition and has not been investigated in detail so far.AimsThe aim of this study was to compare the pH and TOWL of the hand nails after using different primers. The effect of application time, breaks between applications and the method of curing and removal on those parameters and overall nail plates condition were evaluated.Patients/MethodsAn evaluation survey was conducted among 116 women. pH and TOWL measurements of the nail plate in 35 women were taken using the Courage & Khazaka. Clinical photos were made using the Fotomedicus system.ResultsThe measured pH values of the nail plate in the test group with gel polish hybrid on the nails were from 5.50 to 6.65, while after removal of the gel polish hybrid, the values ranged from 5.63 to 6.68. TOWL of the nail plate covered with gel polish hybrid ranged from 2.9 to 33.2 g/m2/h, whereas after removal of hybrids—from 1.9 to 45.7 g/m2/h.ConclusionDifferent forms of acid‐free primers maintain a lower pH of the nail plate covered with a gel polish hybrid, while the acidic primer maintains higher values of the nail plate pH. The significant decrease in the nail plate TOWL following the application of gel polish hybrid indicates a reduced loss of water from the surface of the nail to the atmosphere.
Determinants of depressive mood in coronary artery disease patients with obstructive sleep apnea and response to continuous positive airway pressure treatment in non‐sleepy and sleepy phenotypes in the RICCADSA cohort
Authors: Balcan Baran , Thunström Erik , Strollo Patrick J. , Peker Yüksel 
Published: January 2019

AbstractWe explored determinants of depressive mood in adults with coronary artery disease and obstructive sleep apnea and response to positive airway pressure treatment in sleepy and non‐sleepy phenotypes. In this secondary analysis of the RICCADSA trial conducted in Sweden, 493 cardiac patients with obstructive sleep apnea (n = 386) or no obstructive sleep apnea (n = 107) with complete Epworth Sleepiness Scale and Zung Self‐rating Depression Scale questionnaires were included. Sleepy (Epworth Sleepiness Scale ≥10) versus non‐sleepy (Epworth Sleepiness Scale <10) patients with depressive mood (Zung Self‐rating Depression Scale score ≥50) were evaluated after 3 and 12 months of positive airway pressure treatment. In all, 133 patients (27.0%) had depressive mood (29.3% of obstructive sleep apnea versus 18.7% of no obstructive sleep apnea; p = 0.029), with a higher percentage among the sleepy phenotype (36.9% versus 24.5%; p = 0.009). In multivariate analysis, depressive mood was significantly associated with female sex, body mass index and Epworth Sleepiness Scale. Among 97 obstructive sleep apnea patients with depressive mood at baseline, there was a significant reduction in the scores at follow‐up both in the sleepy and non‐sleepy patients allocated to positive airway pressure treatment, whereas no significant changes were observed in the untreated group (p = 0.033). The device use (hr/night) predicted improvement in mood (odds ratio, 1.33; 95% confidence interval, 1.10–1.61; p = 0.003) adjusted for age, female sex, body mass index, left ventricular ejection fraction, apnea–hypopnea index and delta Epworth Sleepiness Scale score. We conclude that obstructive sleep apnea was associated with depressive mood in adults with coronary artery disease. Treatment with positive airway pressure improved mood in both phenotypes, independent of the confounding factors.