bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct visualization of cAMP signaling in primary cilia reveals up-regulation of ciliary GPCR activity following Hedgehog activation
Authors: Jiang Jason Y. , Falcone Jeffrey L. , Curci Silvana , Hofer Aldebaran M. 
Published: May 2019

Significance
The primary cilium, a small organelle essential to normal development, has recently been thrust into the limelight owing to its involvement in adult disease states such as cancer, obesity, neurodegeneration, and polycystic kidney disease. Here we developed optical approaches to interrogate the function of receptors that work through cAMP-PKA signaling within the primary cilium of live cells. Our data provide a key piece of the puzzle concerning the way in which localized cAMP signals regulate the Hedgehog pathway, another ciliary signaling system with emerging roles in multiple disease processes.
Global soil acidification impacts on belowground processes
Authors: Meng Cheng , Tian Dashuan , Zeng Hui , Li Zhaolei , Yi Chuixiang , Niu Shuli 
Published: May 2019

Abstract
With continuous nitrogen (N) enrichment and sulfur (S) deposition, soil acidification has accelerated and become a global environmental issue. However, a full understanding of the general pattern of ecosystem belowground processes in response to soil acidification due to the impacting factors remains elusive. We conducted a meta-analysis of soil acidification impacts on belowground functions using 304 observations from 49 independent studies, mainly including soil cations, soil nutrient, respiration, root and microbial biomass. Our results show that acid addition significantly reduced soil pH by 0.24 on average, with less pH decrease in forest than non-forest ecosystems. The response ratio of soil pH was positively correlated with site precipitation and temperature, but negatively with initial soil pH. Soil base cations (Ca2+, Mg2+, Na+) decreased while non-base cations (Al3+, Fe3+) increased with soil acidification. Soil respiration, fine root biomass, microbial biomass carbon and nitrogen were significantly reduced by 14.7%, 19.1%, 9.6% and 12.1%, respectively, under acid addition. These indicate that soil carbon processes are sensitive to soil acidification. Overall, our meta-analysis suggests a strong negative impact of soil acidification on belowground functions, with the potential to suppress soil carbon emission. It also arouses our attention to the toxic effects of soil ions on terrestrial ecosystems.
Stochastically modeling the projected impacts of climate change on rainfed and irrigated US crop yields
Authors: Zhu Xiao , Troy Tara J , Devineni Naresh 
Published: May 2019

Abstract
Food demands are rising due to an increasing population with changing food preferences, placing pressure on agricultural production. Additionally, climate extremes have recently highlighted the vulnerability of the agricultural system to climate variability. This study seeks to fill two important gaps in current knowledge: how irrigation impacts the large-scale response of crops to varying climate conditions and how we can explicitly account for uncertainty in yield response to climate. To address these, we developed a statistical model to quantitatively estimate historical and future impacts of climate change and irrigation on US county-level crop yields with uncertainty explicitly treated. Historical climate and crop yield data for 1970–2009 were used over different growing regions to fit the model, and five CMIP5 climate projections were applied to simulate future crop yield response to climate. Maize and spring wheat yields are projected to experience decreasing trends with all models in agreement. Winter wheat yields in the Northwest will see an increasing trend. Results for soybean and winter wheat in the South are more complicated, as irrigation can change the trend in projected yields. The comparison between projected crop yield time series for rainfed and irrigated cases indicates that irrigation can buffer against climate variability that could lead to negative yield anomalies. Through trend analysis of the predictors, the trend in crop yield is mainly driven by projected trends in temperature-related indices, and county-level trend analysis shows regional differences are negligible. This framework provides estimates of the impact of climate and irrigation on US crop yields for the 21st century that account for the full uncertainty of climate variables and the range of crop response. The results of this study can contribute to decision making about crop choice and water use in an uncertain future climate.
Clinical and Histopathologic Predictors of Disaccharidase Deficiency in Duodenal Biopsy Specimens
Authors: Reed Robyn C , Pacheco M Cristina 
Published: May 2019

Abstract

Objectives
Disaccharidase (DS) activity in duodenal biopsy specimens is the gold standard for diagnosing DS deficiency. We investigated strategies to reduce the need for DS testing and whether clinical or histopathologic factors predict DS deficiency.

Methods
A retrospective chart review analyzed 1,678 DS results in children, biopsy indication(s), and duodenal histopathology.

Results
One or more DSs were abnormal in 42.8%. Sufficient lactase predicted sucrase, palatinase, and maltase sufficiency (negative predictive value 97.7%). Three patients had sucrase-isomaltase deficiency (0.2%). DS deficiency was more common in biopsy specimens for positive celiac serology (78.0%). Villous blunting, intraepithelial lymphocytosis, and active inflammation predicted DS deficiency; a combination of any two had an 81.4% positive predictive value.

Conclusions
Utilization could be reduced by only testing cases with normal duodenal histopathology and ongoing clinical suspicion for DS deficiency after reviewing pathology. In cases with suspected celiac disease and/or mucosal injury, DS deficiency is common and likely secondary, limiting test utility.
Are drought resistance strategies associated with life history strategy? A commentary on: ‘Arabidopsis species deploy distinct strategies to cope with drought stress’
Authors: Kooyers Nicholas 
Published: May 2019

This article comments on:
M. Bouzid, F. He, G. Schmitz, R. E. Häusler, A. P. M. Weber, T. Mettler-Altmann and J. de Meaux. 2019. Arabidopsis species deploy distinct strategies to cope with drought stress. Annals of Botany 124(1): 27–40.
VCF/Plotein: visualization and prioritization of genomic variants from human exome sequencing projects
Authors: Ossio Raul , Garcia-Salinas O Isaac , Anaya-Mancilla Diego Said , Garcia-Sotelo Jair S , Aguilar Luis A , Adams David J , Robles-Espinoza Carla Daniela 
Published: May 2019

Abstract

Motivation
Identifying disease-causing variants from exome sequencing projects remains a challenging task that often requires bioinformatics expertise. Here we describe a user-friendly graphical application that allows medical professionals and bench biologists to prioritize and visualize genetic variants from human exome sequencing data.

Results
We have implemented VCF/Plotein, a graphical, fully interactive web application able to display exome sequencing data in VCF format. Gene and variant information is extracted from Ensembl. Cross-referencing with external databases and application-based gene and variant filtering have also been implemented. All data processing is done locally by the user’s CPU to ensure the security of patient data.

Availability and implementation
Freely available on the web at https://vcfplotein.liigh.unam.mx. Website implemented in JavaScript using the Vue.js framework, with all major browsers supported. Source code freely available for download at https://github.com/raulossio/VCF-plotein.

Supplementary information
Supplementary data are available at Bioinformatics online.
Waning of Influenza Vaccine Protection: Exploring the Trade-offs of Changes in Vaccination Timing Among Older Adults
Authors: Ferdinands Jill M , Alyanak Elif , Reed Carrie , Fry Alicia M 
Published: May 2019

Abstract

Background
In recent studies of influenza vaccine effectiveness (VE), lower effectiveness with increasing time since vaccination was observed, raising the question of optimal vaccination timing. We sought to evaluate the estimated number of influenza-associated hospitalizations among older adults due to potential changes in vaccination timing.

Methods
Using empirical data and a health state transition model, we estimated change in influenza-associated hospitalizations predicted to occur among the US population aged ≥65 years if vaccination were delayed until October 1. We assumed the vaccination timing, coverage, and effectiveness observed in 2012–2013 as a prototypical influenza season, approximately 7% monthly waning of VE, and that between 0% and 50% of individuals who usually get vaccinated earlier than October failed to get vaccinated. We also assessed change in influenza-associated hospitalizations if vaccination uptake shifted substantially toward August and September.

Results
In a typical season, delaying vaccination until October increased influenza hospitalizations if more than 14% of older adults usually vaccinated in August and September failed to get vaccinated. The consequences of delayed vaccination depended heavily on influenza season timing, rate of waning, and overall VE. A shift toward vaccination in August and September led to, on average, an increase in influenza-associated hospitalizations, but this result was also sensitive to influenza season timing.

Conclusions
Consequences of delayed vaccination varied widely. Uncertainties about vaccine waning and effects of a delay on vaccine coverage suggest it is premature to change current vaccine recommendations, although it may be prudent to prevent a substantial shift toward early vaccination.
NuDist: An Efficient Local Search Algorithm for (Weighted) Partial MaxSAT
Authors: Lei Zhendong , Cai Shaowei 
Published: May 2019

Abstract
Maximum satisfiability (MaxSAT) is the optimization version of the satisfiability (SAT). Partial MaxSAT (PMS) generalizes SAT and MaxSAT by introducing hard and soft clauses, while Weighted PMS (WPMS) is the weighted version of PMS where each soft clause has a weight. These two problems have many important real-world applications. Local search is a popular method for solving (W)PMS. Recently, significant progress has been made in this direction by tailoring local search for (W)PMS, and a representative algorithm is the Dist algorithm. In this paper, we propose two ideas to improve Dist, including a clause-weighting scheme and a variable-selection heuristic. The resulting algorithm is called NuDist. Extensive experiments on PMS and WPMS benchmarks from the MaxSAT Evaluations (MSE) 2016 and 2017 show that NuDist significantly outperforms state-of-the-art local search solvers and performs better than state-of-the-art complete solvers including Open-WBO and WPM3 on MSE 2017 benchmarks. Also, empirical analyses confirm the effectiveness of the proposed ideas.
Deep Reinforcement Learning with Adaptive Update Target Combination
Authors: Xu Z , Cao L , Chen X 
Published: May 2019

Abstract
Simple and efficient exploration remains a core challenge in deep reinforcement learning. While many exploration methods can be applied to high-dimensional tasks, these methods manually adjust exploration parameters according to domain knowledge. This paper proposes a novel method that can automatically balance exploration and exploitation, as well as combine on-policy and off-policy update targets through a dynamic weighted way based on value difference. The proposed method does not directly affect the probability of a selected action but utilizes the value difference produced during the learning process to adjust update target for guiding the direction of agent’s learning. We demonstrate the performance of the proposed method on CartPole-v1, MountainCar-v0, and LunarLander-v2 classic control tasks from the OpenAI Gym. Empirical evaluation results show that by integrating on-policy and off-policy update targets dynamically, this method exhibits superior performance and stability than does the exclusive use of the update target.
Clinical outcomes in patients with primary stable microvascular angina: is the jury still out?
Authors: Lanza Gaetano Antonio , Crea Filippo , Kaski Juan Carlos 
Published: May 2019

Abstract
Several studies have demonstrated that angina chest pain in presence of normal or near normal coronary arteries (NCAs) is mainly related to coronary microvascular dysfunction (CMD). However, controversial findings exist about clinical outcome of these patients. In this article, we critically review characteristics and results of the main clinical studies reporting clinical outcome of stable patients with angina chest pain and non-obstructive coronary artery disease (NO-CAD). Published data indicate that clinical outcomes of these patients are heterogeneous, but those with strict criteria for primary stable microvascular angina (MVA, i.e. typical angina with NCAs mainly related to efforts) do not appear to have an increased mortality or risk of major coronary events. A major determinant of outcome in patients with MVA and NO-CAD seems instead related to non-critical atherosclerotic disease, the presence of which should suggest a more aggressive management of cardiovascular risk factors and preventive management. Future studies should assess whether CMD may have a relevant prognostic role in the latter clinical context and/or in other clinical settings of NO-CAD different from primary stable MVA.
The Armed Forces and Parliamentary Elections in the United Kingdom, 1885–1914
Authors: Keeling Peter M 
Published: May 2019

Abstract
This article discusses the electoral position of the British Army and Royal Navy during the period between the Third Reform Act and the outbreak of war in 1914, offering a ‘bottom up’ perspective on the history of civil–military relations. Drawing heavily from contemporary newspapers and electoral registers, it shows that in a number of constituencies soldiers and sailors held significant voting influence. Because soldiers were assumed to be natural Conservatives, the struggle between Tory and Liberal election agents over their registration sheds light on the nature of local party politics during this time, as well as the practical operation of what was a complex and unsympathetic electoral system. More broadly, it offers a case-study in ‘positive Unionism’, which challenges the view of the Conservative Party as an unbending opponent of franchise reform and, similarly, sheds light on the less democratic side of the Liberal Party. In terms of the armed forces themselves, the article argues that while the Army harboured a strong Unionist identity, the Navy was much less partisan in its voting habits; Irish soldiers proved themselves Liberal in sympathies. Overall, the article provides a fresh perspective on the position of the Army and Navy in British society during the late nineteenth and early twentieth centuries, and, in its conclusion, adds context to the 1918 Representation of the People Act.
The impact of centre volume on outcomes of orthotopic heart transplant in older recipients
Authors: Sultan Ibrahim , Gleason Thomas G , Kagawa Hiroshi , Keebler Mary , Mathier Michael , Kormos Robert L , Kilic Arman 
Published: May 2019

Abstract

OBJECTIVES
The aim of this study was to evaluate the impact of overall and older-recipient-specific centre volumes on outcomes of orthotopic heart transplant (OHT) in older recipients.

METHODS
Patients aged ≥60 years undergoing OHT were identified in the United Network for Organ Sharing (UNOS) registry. The primary outcome was 1-year post-OHT mortality. Secondary outcomes included the incidence and impact on 1-year survival of postoperative complications including infection, renal failure requiring dialysis and stroke. Patients were divided into equal size tertiles based on overall and older-recipient-specific OHT centre volumes.

RESULTS
A total of 5373 older recipients were identified. Mean overall and older-recipient-specific volumes were 27.5 ± 19.5 and 9.4 ± 7.3 OHT/year, respectively. Although overall and older-recipient-specific low-volume centres were at higher risk of mortality in separate multivariable analysis, only older-recipient-specific volume contributed significantly to post-OHT mortality in the combined multivariable analysis (P < 0.05). In the receiver operating characteristic analysis, an older-recipient-specific volume of 8 OHTs/year was identified as the most discriminative volume threshold for mortality (area under the receiver operating characteristic curve = 0.68). Although low older-recipient-specific volume centres did not have significantly higher incidences of postoperative complications, they had significantly worse 1-year survival rates compared to higher volume centres in patients with postoperative infection or dialysis (each P < 0.01).

CONCLUSIONS
This large-cohort analysis demonstrates that older-recipient-specific centre volume contributes to post-OHT outcomes in the older recipients more significantly than overall volume. This may be a consequence of higher older-recipient-specific volume centres to better manage specific complications in this patient population.
Experimental investigation and performance analysis of an Organic Rankine Cycle for low-temperature heat to electricity generation
Authors: Wei Lili , Ma Zhenjun , Gong Xuemei , Guo Xiujuan 
Published: May 2019

Abstract
This paper presents experimental investigation of low-temperature heat to electricity generation system based on Organic Rankine Cycle (ORC) using R152a as the working fluid. Both energy efficiency and exergy efficiency were analyzed based on the experiments. Although energy efficiency was low to 5.0% when the evaporating and cooling temperatures were 65°C and 11°C, respectively, the exergy efficiency reached 25%, which showed great competitiveness among low-temperature heat utilization technologies. To reveal the energy recovery proportion from the waste heat, both energy extraction efficiency and exergy extraction efficiency as well as energy and exergy loss paths were analyzed. When the heat source was 65°C, 14.9% of the maximum possible thermal energy in the heat source was absorbed by the organic working fluid, and 10.7% was transferred to the cooling medium. The power output contributed 0.64%. A total of 1.8% of the exergy in the heat stream flowed to the cooling medium. The start-up work takes dramatically 0.16% and 1.7% of energy and exergy, respectively. Other energy and exergy loss occurs due to the irreversibility of the heat transfer process and expansion process. Cascade ORC system could enlarge the temperature difference of the heat stream and raise the power output. However, the energy efficiency of the multi-stage ORC system is lower than single-stage system, since there was a downward trend of the temperature of heat source for the latter stage. ORC cycle can lower the temperature of heat source to 45°C.
China’s rising assertiveness and the decline in the East Asian regionalism narrative
Authors: Yeo Andrew 
Published: May 2019

AbstractAfter a decade of vibrant scholarly and political discourse regarding the prospects of East Asian integration, the narrative of regionalism has lost its luster in favor of a darker regional narrative. Has the idea of East Asian regionalism come to pass, and if so, what explains the decline in the narrative of Asian regionalism both as a policy idea and as a research program? After providing empirical evidence tracking the rise and decline in scholarly publications and news articles regarding Asian regionalism, I present several plausible reasons explaining this decline. Among them, the perceived shift in Chinese strategic behavior, and in turn, the adoption of more pragmatic interpretations of Asian security practices – one defined by power balancing and institutional rivalry rather than community building – appears to have struck a major blow to the East Asia regional project.
Autotomy and running performance of fiddler crabs (Decapoda: Brachyura: Ocypodidae)
Authors: Martin Benjamin E 
Published: May 2019

Abstract
The sexually dimorphic, enlarged major claw is a notorious trait among male fiddler crabs, but comes with potential locomotor costs. Possessing the ability to autotomize the enlarged claw is thus potentially advantageous to not only to escape a predator’s grip, but also to increase running performance. Previous studies concluded that autotomy either has no effect or even a negative effect on running performance. If the claw does not aid in locomotion, then shedding the enlarged claw that accounts for 40% of a fiddler crab’s mass should positively affect running performance. I therefore investigated autotomy and running performance in the Atlantic sand fiddler crab Leptuca pugilator (Bosc, 1801) with a focus on improving upon the methods of previous studies. Crabs were given substantial recovery time between collection, running trials, and autotomy induction. Maximum sprint speed was assessed by running crabs on a 1 m sand and mud track where individuals were significantly faster after autotomy of the enlarged claw (N = 64, t63=-7.25, P < 0.001). Intact running velocity was furthermore a significant predictor of autotomized running velocity (R2 = 0.194, P < 0.001). This study is the first to show a significant increase in fiddler crab sprint velocity after autotomy on a flat surface, and I propose where methodological pitfalls may have occurred in previous studies.
Assessing Victim Participation during Sentencing at the International Criminal Court
Authors: Pérez-León-Acevedo Juan-Pablo 
Published: May 2019

Abstract
Although the academic literature has examined victim participation at the International Criminal Court (ICC), victim participation during the sentencing stage has remained a virtually unexplored topic. Thus, this article assesses the law and, in particular, the practice of the ICC on victim participation during sentencing in light of domestic/international criminal law and human rights law standards. Victim participation during the ICC sentencing stage, i.e. mainly written observations and sentencing hearing participation, is overall consistent with international and domestic criminal law standards, particularly with certain common law jurisdictions and with the Special Tribunal for Lebanon where the trial and sentencing stages are also divided. Additionally, victim participation during the ICC sentencing stage may arguably be justified under international human rights law, especially human rights case law. Importantly, the ICC has introduced some limitations to victim participation to safeguard the convicted person’s rights and procedural efficiency.
Political Agency, Oversight, and Bias: The Instrumental Value of Politicized Policymaking
Authors: Turner Ian R 
Published: May 2019

AbstractWe develop a theory of policymaking between an agent and an overseer, with a principal whose welfare is affected by agent-overseer interactions. The agent can increase the quality of policy outcomes through costly capacity investments. Oversight and agent bias jointly determine optimal agent capacity investments. We show that when oversight improves agent investment incentives the principal always benefits from an agent with biases opposite the overseer. Competing agent-overseer biases translate into higher quality policy outcomes than the principal could induce were she monitoring the agent. Effective oversight is necessary for these incentive effects. The results imply that political principals ought to consider the nature of the broader policymaking environment when appointing agents to make policy on their behalf and when designing managerial strategies aimed at motivating agents. (JEL D73, D82, H11)