bluuebunny/crossref_metadata_2025_split huggingface dataset:
ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism
Authors: Nanda Sambit K. , Nagamori Tsunehisa , Windheim Mark , Amu Sylvia , Aviello Gabriella , Patterson-Kane Janet , Arthur J. Simon C. , Ley Steven C. , Fallon Padraic , Cohen Philip 
Published: October 2018

Abstract
The A20-binding inhibitor of NF-κB 2 (ABIN2) interacts with Met1-linked ubiquitin chains and is an integral component of the tumor progression locus 2 (Tpl2) kinase complex. We generated a knock-in mouse expressing the ubiquitin-binding–defective mutant ABIN2[D310N]. The expression of Tpl2 and its activation by TLR agonists in macrophages or by IL-1β in fibroblasts from these mice was unimpaired, indicating that the interaction of ABIN2 with ubiquitin oligomers is not required for the stability or activation of Tpl2. The ABIN2[D310N] mice displayed intestinal inflammation and hypersensitivity to dextran sodium sulfate–induced colitis, an effect that was mediated by radiation-resistant cells rather than by hematopioetic cells. The IL-1β–dependent induction of cyclooxygenase 2 (COX2) and the secretion of PGE2 was reduced in mouse embryonic fibroblasts and intestinal myofibroblasts (IMFs) from ABIN2[D310N] mice. These observations are similar to those reported for the Tpl2 knockout (KO) mice (Roulis et al. 2014. Proc. Natl. Acad. Sci. USA 111: E4658–E4667), but the IL-1β–dependent production of COX2 and PGE2 in mouse embryonic fibroblasts or IMFs was unaffected by pharmacological inhibition of Tpl2 in wild-type mice. The expression of ABIN2 is decreased drastically in Tpl2 KO mice. These and other lines of evidence suggest that the hypersensitivity of Tpl2 KO mice to dextran sodium sulfate–induced colitis is not caused by the loss of Tpl2 catalytic activity but by the loss of ABIN2, which impairs COX2 and PGE2 production in IMFs by a Tpl2 kinase–independent pathway.
Estrogen Signaling in Bystander Foxp3neg CD4+ T Cells Suppresses Cognate Th17 Differentiation in Trans and Protects from Central Nervous System Autoimmunity
Authors: Garnier Laure , Laffont Sophie , Lélu Karine , Yogev Nir , Waisman Ari , Guéry Jean-Charles 
Published: October 2018

Abstract
17β-Estradiol (E2) suppresses the development of experimental autoimmune encephalomyelitis (EAE) through estrogen receptor (ER) α, yet the cellular targets remain elusive. We have used an adoptive transfer model of myelin oligodendrocyte glycoprotein–specific CD4+ T cells from 2D2 TCR transgenic mice. We show that in the recipient mice, ERα expression in bystander CD4+ T cells, rather than in cognate 2D2 T cells, is required for the inhibition of Th17 cell differentiation by E2. Coadministration of estrogen-primed WT, but not ERα-deficient CD4+ T cells, with naive 2D2 T cells lacking ERα inhibited the development of Th17 cell–mediated EAE. Suppression of Th17 cells and protection from EAE were maintained when ERα was deleted in Foxp3+ regulatory T cells. We showed that in vivo PD-L1 blockade alleviated the anti-inflammatory action of E2 and that PD-1 expression on cognate but not bystander T cells was required for the E2-dependent inhibition of Th17 differentiation. In cotransfer experiments, we found that only WT but not PD-1KO 2D2 T cells were amenable to E2-dependent inhibition of Th17 differentiation. These results support the conclusion that the restriction of Th17 cell development by E2-primed bystander CD4+ T cells requires cell-intrinsic PD-1 signaling within cognate T cells rather than induction of regulatory 2D2 T cells through PD-1 engagement. Altogether, our results indicate that pregnancy-level concentrations of estrogen signal in conventional Foxp3neg CD4+ T cells to limit the differentiation of cognate Th17 cells through a trans-acting mechanism of suppression that requires a functional PD-1/PD-L1 regulatory axis.
Thermal Stress Analysis for High CRI LED Indoor Lighting Module
Authors: Lee Jonghwan , Kwon Ki-Youn 
Published: October 2018

AbstractThis research is for developing a new light emitting diode (LED) indoor lighting module with high color rendering index greater than 95. When the LED is operated, electrical energy is generated and heat is released. The failing of heat dispersal degrades the performance and decreases the operating life. To manage the thermal problem effectively, several approaches have been tested in this research study. A heat sink is designed to absorb and transfer heat from the LED module. To analyze the heat flow and thermal stress of the designed LED products effectively, hexahedral mesh generation has been implemented. Heat transfer analysis was performed to find an optimal conductive material. The outcomes of this research study suggest the best material for LED products and show the result of thermal transfer simulation.
Comparison Geometry of Manifolds with Boundary under a Lower Weighted Ricci Curvature Bound
Authors: Sakurai Yohei 
Published: October 2018

AbstractWe study Riemannian manifolds with boundary under a lower weighted Ricci curvature bound. We consider a curvature condition in which the weighted Ricci curvature is bounded from below by the density function. Under the curvature condition and a suitable condition for the weighted mean curvature for the boundary, we obtain various comparison geometric results.
The Coniveau Filtration on for Some Severi–Brauer Varieties
Authors: Mackall Eoin 
Published: October 2018

AbstractWe produce an isomorphism $E_{\infty }^{m,-m-1}\cong \text{Nrd}_{1}(A^{\otimes m})$ between terms of the $\text{K}$-theory coniveau spectral sequence of a Severi–Brauer variety $X$ associated with a central simple algebra $A$ and a reduced norm group, assuming $A$ has equal index and exponent over all finite extensions of its center and that $\text{SK}_{1}(A^{\otimes i})=1$ for all $i>0$.
Online model calibration for a simplified LES model in pursuit of real-time closed-loop wind farm control
Authors: Doekemeijer Bart M. , Boersma Sjoerd , Pao Lucy Y. , Knudsen Torben , van Wingerden Jan-Willem 
Published: October 2018

Abstract. Wind farm control often relies on computationally inexpensive surrogate
models to predict the dynamics inside a farm. However, the reliability of
these models over the spectrum of wind farm operation remains questionable
due to the many uncertainties in the atmospheric conditions and
tough-to-model dynamics at a range of spatial and temporal scales relevant
for control. A closed-loop control framework is proposed in which a
simplified model is calibrated and used for optimization in real time. This
paper presents a joint state-parameter estimation solution with an ensemble
Kalman filter at its core, which calibrates the surrogate model to the actual
atmospheric conditions. The estimator is tested in high-fidelity simulations
of a nine-turbine wind farm. Exclusively using measurements of each turbine's generated power, the adaptability to modeling errors and mismatches in
atmospheric conditions is shown. Convergence is reached within 400 s of
operation, after which the estimation error in flow fields is negligible. At
a low computational cost of 1.2 s on an 8-core CPU, this algorithm shows
comparable accuracy to the state of the art from the literature while being
approximately 2 orders of magnitude faster.
PORTAS ENTREABERTAS DO BRASIL: NARRATIVAS DE MIGRANTES DE CRISE SOBRE POLÍTICAS PÚBLICAS DE ACOLHIMENTO
Authors: Camargo Helena Regina Esteves de 
Published: October 2018

Em um momento em que o Brasil ingressa na rota de novos fluxos migratórios em Em um momento em que o Brasil ingressa na rota de novos fluxos migratórios em decorrência das consequências da globalização que, para muitos, apresenta-se em sua versão perversa (SANTOS, 2001), faz-se necessário investigar como os migrantes vivenciam as políticas públicas voltadas para seu acolhimento e inserção social no país. O presente artigo objetiva, a partir das narrativas de dois migrantes residentes no município de São Paulo, analisar como mecanismos de regulamentação de entrada e permanência no país e políticas de acolhimento disponíveis são vivenciados por eles e, partindo dessas reflexões, levantar algumas implicações sobre políticas de acolhimento. As narrativas foram geradas por meio de conversas informais áudio-gravadas com o objetivo de relatar a experiência vivida pelos migrantes em relação à acolhida e às possibilidades de inserção social no país. As análises das narrativas mostram que, apesar dos avanços legislativos e de ações institucionais voltadas ao acolhimento e inserção social, ainda fazem falta medidas que viabilizem a concessão de vistos de entrada, a permissão ao vínculo empregatício, bem como políticas de línguas para ampliar o acesso à informação e auxiliar no processo de (re)reterritorialização (HAESBAERT, 2004; BIZON, 2013).
VOZES DO PROGRAMA EMERGENCIAL PRÓ-HAITI: NARRATIVAS DE RACIALIZAÇÃO DO “SER HAITIANO”
Authors: Bizon Ana Cecília Cossi , Dangió Gabriel Vinícius 
Published: October 2018

O presente artigo tem como objetivo refletir sobre o processo de inserção de estudantes estrangeiros provenientes de países periféricos (WALLERSTEIN, 1974), no caso haitianos, no ambiente universitário brasileiro. Para tanto, como dados primários, são focalizados excertos de narrativas de dois estudantes do Programa Emergencial em Educação Superior Pró-Haiti, em uma universidade pública brasileira, geradas a partir de conversas informais audiogravadas. Tais narrativas topicalizam os sentidos produzidos pelas experiências de reterritorialização (HAESBAERT, 2004; BIZON, 2013) desses jovens ao longo de sua estadia no Brasil. Além disso, como dados secundários, considera-se um excerto de narrativa de uma jovem estadunidense negra participante de um programa de mobilidade em uma universidade federal brasileira. Acreditamos que a análise das narrativas dos estudantes haitianos na interface com a narrativa da jovem estadunidense seja potencialmente capaz de lançar luzes sobre particularidades dos processos de (re)territorialização de estrangeiros oriundos de países não centrais. A análise dos dados indica que processos de racialização (SILVERSTEIN, 2005; BUTLER, 2004; GALABUZI, 2006; BIZON & CAVALCANTI, 2018) experienciados pelos estudantes haitianos incidem fortemente em suas (re)territorializações. O imaginário socialmente articulado do que é ser haitiano, negro, estrangeiro, dentre outras identificações, é mobilizado nas relações que esses estudantes estabelecem nas diferentes práticas sociais nas quais se engajam, gerando percepções de discriminação e exclusão. Espera-se, com a visibilização dessas narrativas (WORTHAM, 2001; THREADGOLD, 2005; BAYNHAM & DE FINA, 2017), contribuir para a discussão de políticas de inserção no contexto de internacionalização de nossas universidades, as quais ainda privilegiam o diálogo com países centrais e atores hegemônicos.
Spontaneous omental bleeding in a 20-year old patient with hemophilia A
Authors: Meyer F. , Wybranski C. , Bruns C. J. , Jannasch O. , Aumann V. , Chiapponi C. 
Published: October 2018

SummarySpontaneous intraabdominal hemorrhage is a very rare event even in patients with bleeding disorders like hemophilia. Nevertheless this rare case must be considered in patients with coagulopathies presenting with abdominal pain. Prompt radiologic imaging and surgical consultation are of highest priority. Here we report on a 20-year-old patient with moderate hemophilia A, who underwent emergency laparotomy for a spontaneous idiopathic bleeding of the omentum majus. There are few cases in the literature on this sort of event in patients with hemophilia, who mostly suffer from spontaneous joint bleedings. These patients require an intensive, interdisciplinary perioperative care, involving haematologists, surgeons, radiologists and anesthesists. Finally we discuss, whether an optimized, individually adapted treatment with coagulation factors might possibly have prevented this bleeding event in this patient.
Repeated Administration of Idarucizumab to a Patient with Dabigatran Overdose
Authors: Šigutová Pavla , Lavičková Alena , Hajšmanová Zdeňka 
Published: October 2018

SummaryIdarucizumab is designed to reverse the anticoagulant effect of dabigatran. This case report describes the administration of three independent doses of idarucizumab to a 76-year-old man suffering from atrial flutter being treated with dabigatran to prevent ischaemic stroke. The last dose of dabigatran was administered in the morning of the same day the patient was transferred to hospital because of the need for urgent pericardium puncture. Baseline dTT (dilute thrombin time) reached 700 ng/mL as glomerular filtration (GF) dropped to 0.19 mL/s. The first dose of idarucizumab was administered prior to puncture and the clinical state was stabilized for the next 24 hours although dTT climbed to 400 ng/mL. The need for cannulation before dialysis required a second dose of antidote and a third dose was given prior to removal of the pericardium drain. Monitoring of dabigatran recovery showed that the reverse effect of idarucizumab lasted 12 hours, which is sufficiently long and reliable for urgent situations. Idarucizumab administration is not limited by age and/or renal impairment. We recommend repeated dTT examinations when the dabigatran baseline level exceeds 200 ng/mL and the antidote has been administered.
Spatial-temporal Assessment and Mapping of the Air Quality and Noise Pollution in a Sub-area Local Environment inside the Center of a Latin American Megacity: Universidad Nacional de Colombia - Bogotá Campus
Authors: Luna Guevara , Alejandro Fredy , Luna Guevara , Andrés Marco , Roa Rojas , Yezid Néstor 
Published: October 2018

Abstract
The construction, development and maintenance of an economically, environmentally and socially sustainable campus involves the integration of measuring tools and technical information that invites and encourages the community to know the actual state to generate positive actions for reducing the negative impacts over the local environment. At the Universidad Nacional de Colombia - Campus Bogotá, a public area with daily traffic of more than 25000 people, the Environmental Management Bureau has committed with the monitoring of the noise pollution and air quality, as support to the campaigns aiming to reduce the pollutant emissions associated to the student’s activities and campus operation. The target of this study is based in the implementation of mobile air quality and sonometry monitoring equipment, the mapping of the actual air quality and noise pollution inside the university campus as a novel methodology for a sub-area inside a megacity. This results and mapping are proposed as planning tool for the institution administrative sections. A mobile Kunak® Air & OPC air monitoring station with the capability to measure particulate matter PM10, PM25, Ozone (O3), Sulfur Oxide (SO2), Carbon Monoxide (CO) and Nitrogen Oxide (NO2) as well as Temperature, Relative Humidity and Latitude and Longitude coordinates for the data georeferenciation; and a sonometer Cirrus® 162B Class 2 were used to perform the measurements. The measurements took place in conditions of academic activity and without it, with the aim of identify the impacts generated by the campus operation. Using the free code geographical information software QGIS® 2.18, the maps of each variable measured were developed, and the impacts generated by the operation of the campus were identified qualitative and quantitively. For the measured variables, an increase of around 21% for the LAeq noise level and around 80% to 90% for air pollution were detected during the operation period.
Implementação de um Modelo Bag of Features para Classificação de Frutas
Authors: Christmann Guilherme Henrique Galelli , Montenegro Fabrício Julian Carini , Grando Ricardo Bedin , Guerra Rodrigo da Silva 
Published: October 2018

Este trabalho explora uma técnica clássica de visão computacional, o modelo de Bag of Features, em um problema de classificação de frutas e vegetais. Há uma tendência crescente no uso de técnicas de Redes Neurais e Deep Learning aplicadas na automatização de processos e sistemas. Esse trabalho vai contra essa tendência, examinando o desempenho de um modelo de Machine Learning (ML) mais simples. Para tal, definimos dois cenários, um em que o ambiente é controlado com apenas diferenças de iluminação e posições dos objetos e, outro, com imagens mais desafiadoras, com maior presença de ruído no background. Mostramos que apesar de existir uma clara tendência ao uso de modelos complexos de ML, técnicas mais simples continuam relevantes em certos cenários.
Using C‐Arm X‐ray images from marker insertion to confirm the gold fiducial marker identification in an MRI‐only prostate radiotherapy workflow
Authors: Gustafsson Christian , Persson Emilia , Gunnlaugsson Adalsteinn , Olsson Lars E. 
Published: October 2018

AbstractProstate cancer radiotherapy workflows, solely based on magnetic resonance imaging (MRI), are now in clinical use. In these workflows, intraprostatic gold fiducial markers (GFM) show similar signal behavior as calcifications and bleeding in T2‐weighted MRI‐images. Accurate GFM identification in MRI‐only radiotherapy workflows is therefore a major challenge. C‐arm X‐ray images (CkV‐images), acquired at GFM implantation, could provide GFM position information and be used to confirm correct identification in T2‐weighted MRI‐images. This would require negligible GFM migration between implantation and MRI‐imaging. Marker migration was therefore investigated. The aim of this study was to show the feasibility of using CkV‐images to confirm GFM identification in an MRI‐only prostate radiotherapy workflow. An anterior‐posterior digitally reconstructed radiograph (DRR)‐image and a mirrored posterior‐anterior CkV‐image were acquired two weeks apart for 16 patients in an MRI‐only radiotherapy workflow. The DRR‐image originated from synthetic CT‐images (created from MRI‐images). A common image geometry was defined between the DRR‐ and CkV‐image for each patient. A rigid registration between the GFM center of mass (CoM) coordinates was performed and the distance between each of the GFM in the DRR‐ and registered CkV‐image was calculated. The same methodology was used to assess GFM migration for 31 patients in a CT‐based radiotherapy workflow. The distance calculated was considered a measure of GFM migration. A statistical test was performed to assess any difference between the cohorts. The mean absolute distance difference for the GFM CoM between the DRR‐ and CkV‐image in the MRI‐only cohort was 1.7 ± 1.4 mm. The mean GFM migration was 1.2 ± 0.7 mm. No significant difference between the measured total distances of the two cohorts could be detected (P = 0.37). This demonstrated that, a C‐Arm X‐ray image acquired from the GFM implantation procedure could be used to confirm GFM identification from MRI‐images. GFM migration was present but did not constitute a problem.
Azathioprine and Mycophenolate Mofetil Adherence Patterns and Predictors Among Medicaid Beneficiaries With Systemic Lupus Erythematosus
Authors: Feldman Candace H. , Collins Jamie , Zhang Zhi , Xu Chang , Subramanian S. V. , Kawachi Ichiro , Solomon Daniel H. , Costenbader Karen H. 
Published: October 2018

ObjectiveAzathioprine (AZA) and mycophenolate mofetil (MMF) are immunosuppressants frequently used in the treatment of moderate‐to‐severe systemic lupus erythematosus (SLE). We studied longitudinal patterns and predictors of adherence to AZA and MMF in a nationwide US SLE cohort.MethodsIn the Medicaid Analytic eXtract (2000–2010) database, we identified patients with SLE who initiated AZA or MMF (no use in the prior 6 months) with ≥12 months of continuous follow‐up. We dichotomized adherence at 80%, with ≥24 of 30 days per month considered adherent. We used group‐based trajectory models to estimate monthly adherence patterns and multivariable multinomial logistic regression to determine the association between demographic, SLE and utilization‐related predictors, and the odds ratios (OR) of belonging to a nonadherent versus the adherent trajectory, separately for AZA and MMF.ResultsWe identified 2,309 AZA initiators and 2,070 MMF initiators with SLE. Four‐group trajectory models classified 17% of AZA and 21% of MMF initiators as adherent. AZA and MMF nonadherers followed similar trajectory patterns. African American race (OR 1.67 [95% confidence interval (95% CI) 1.20–2.31]) and Hispanic ethnicity (OR 1.58 [95% CI 1.06–2.35]) increased odds of AZA nonadherence; there were no significant associations between race/ethnicity and MMF nonadherence. Male sex and polypharmacy were associated with lower odds of nonadherence to both medications; lupus nephritis was associated with lower odds of nonadherence to MMF (OR 0.74 [95% CI 0.55–0.99]).ConclusionAdherence to AZA or MMF over the first year of use was rare. Race, sex, and lupus nephritis were modestly associated with adherence, but the magnitude, direction, and significance of predictors differed by medication, suggesting the complexity of predicting adherence behavior.
Toward Development of Inflatable Stents with Application in Endovascular Treatments
Authors: Amiri Moghadam Amir Ali , Alaie Seyedhamidreza , Gharaie Saleh , Nath Suborna Deb , Vawda Sumayya , Al'Aref Subhi J. , Romito Eva A. , Kolli Kranthi K. , Min James K. , Dunham Simon , Mosadegh Bobak 
Published: October 2018

AbstractAlthough design and fabrication of metallic stents are extensively explored and established, the application of inflatable stents in endovascular treatments is relatively new. Inflatable stents introduce several advantages, such as repositionability and conformability to surrounding anatomic structures. These characteristics make the stent suitable for transcatheter treatment of cardiovascular diseases, such as valvular heart disease, and aortic aneurysms. This paper reports on a rapid and cost‐effective fabrication method, based on soft robotic technology, for the development of inflatable stents made of thermoplastic polyurethane. The stent is an inflatable cylinder that contains an array of bonded regions that form a continuous network, resembling a hexagonal lattice pattern. This pattern prevents the stent from buckling into an irregular shape upon inflation. The effect of this pattern on the maximum burst pressure, thickness, and pull‐out force of the stent is characterized. Finally, a trileaflet polyurethane valve is integrated into the inflatable stent frame to demonstrate its application as a transcatheter heart valve. This work serves as a proof of principle that inflatable stents can be useful in cardiovascular applications where conformability to surrounding tissue is advantageous, such as abdominal aortic aneurysm and aortic valve replacement.
In Situ Synchrotron X‐Ray Diffraction Analysis of Phase Transformation in Epitaxial Metastable hcp Nickel Thin Films, Prepared via Plasma‐Enhanced Atomic Layer Deposition
Authors: Motamedi Pouyan , Bosnick Ken , Cadien Ken , Hogan James D. 
Published: October 2018

AbstractUltrathin metal films have a wide variety of applications, especially in microelectronics. A key method to deposit these films is plasma‐enhanced atomic layer deposition (PEALD), which is known for its ability to deposit thin films conformally and at relatively low temperatures. Building on the recent work, an improved recipe is reported on for the development of nickel PEALD technology, through which fully epitaxial nickel thin films are deposited. The effect of continuous heating on the phase structure and agglomeration in the metastable thin films is investigated in this paper. The variations of the phase structure are monitored via in situ synchrotron X‐ray diffraction, as well as optical roughness analysis. The temperature windows for phase transformation and particle formation are determined. It is noted that, after the hcp‐to‐fcc transformation and particle coalescence processes are complete, the particles reshape to acquire the thermodynamically stable shapes dictated by the Wulff theorem. Additionally, a crystallographic orientation relationship between the fcc particles and the sapphire substrate is observed, i.e., Ni (111)||Sapphire(002).