bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson’s disease
Authors: Brahmachari Saurav , Lee Saebom , Kim Sangjune , Yuan Changqing , Karuppagounder Senthilkumar S , Ge Preston , Shi Rosa , Kim Esther J , Liu Alex , Kim Donghoon , Quintin Stephan , Jiang Haisong , Kumar Manoj , Yun Seung Pil , Kam Tae-In , Mao Xiaobo , Lee Yunjong , Swing Deborah A , Tessarollo Lino , Ko Han Seok , Dawson Valina L , Dawson Ted M 
Published: May 2019

Abstract
α-Synuclein misfolding and aggregation plays a major role in the pathogenesis of Parkinson’s disease. Although loss of function mutations in the ubiquitin ligase, parkin, cause autosomal recessive Parkinson’s disease, there is evidence that parkin is inactivated in sporadic Parkinson’s disease. Whether parkin inactivation is a driver of neurodegeneration in sporadic Parkinson’s disease or a mere spectator is unknown. Here we show that parkin in inactivated through c-Abelson kinase phosphorylation of parkin in three α-synuclein-induced models of neurodegeneration. This results in the accumulation of parkin interacting substrate protein (zinc finger protein 746) and aminoacyl tRNA synthetase complex interacting multifunctional protein 2 with increased parkin interacting substrate protein levels playing a critical role in α-synuclein-induced neurodegeneration, since knockout of parkin interacting substrate protein attenuates the degenerative process. Thus, accumulation of parkin interacting substrate protein links parkin inactivation and α-synuclein in a common pathogenic neurodegenerative pathway relevant to both sporadic and familial forms Parkinson’s disease. Thus, suppression of parkin interacting substrate protein could be a potential therapeutic strategy to halt the progression of Parkinson’s disease and related α-synucleinopathies.
One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi
Authors: Kanyama Cecilia , Molloy Síle F , Chan Adrienne K , Lupiya Duncan , Chawinga Chimwemwe , Adams Jack , Bright Philip , Lalloo David G , Heyderman Robert S , Lortholary Olivier , Jaffar Shabbar , Loyse Angela , van Oosterhout Joep J , Hosseinipour Mina C , Harrison Thomas S 
Published: May 2019

Abstract
In Malawi, 236 participants from the Advancing Cryptococcal Meningitis Treatment for Africa trial were followed for 12 months. The trial outcomes reported at 10 weeks were sustained to 1 year. One-week amphotericin B plus flucytosine was associated with the lowest 1 year mortality (27.5% [95% confidence interval, 16.3 to 44.1]).
Declines in Pneumonia and Meningitis Hospitalizations in Children Under 5 Years of Age After Introduction of 10-Valent Pneumococcal Conjugate Vaccine in Zambia, 2010–2016
Authors: Mpabalwani Evans M , Lukwesa-Musyani Chileshe , Imamba Akakambama , Nakazwe Ruth , Matapo Belem , Muzongwe Chilweza M , Mufune Trust , Soda Elizabeth , Mwenda Jason M , Lutz Chelsea S , Pondo Tracy , Lessa Fernanda C 
Published: May 2019

Abstract

Background
Pneumococcus is a leading cause of pneumonia and meningitis. Zambia introduced a 10-valent pneumococcal conjugate vaccine (PCV10) in July 2013 using a 3-dose primary series at ages 6, 10, and 14 weeks with no booster. We evaluated the impact of PCV10 on meningitis and pneumonia hospitalizations.

Methods
Using hospitalization data from first-level care hospitals, available at the Ministry of Health, and from the largest pediatric referral hospital in Lusaka, we identified children aged <5 years who were hospitalized with pneumonia or meningitis from January 2010–December 2016. We used time-series analyses to measure the effect of PCV10 on monthly case counts by outcome and age group (<1 year, 1–4 years), accounting for seasonality. We defined the pre- and post-PCV10 periods as January 2010–June 2013 and July 2014–December 2016, respectively.

Results
At first-level care hospitals, pneumonia and meningitis hospitalizations among children aged <5 years accounted for 108 884 and 1742 admissions in the 42 months pre-PCV10, respectively, and 44 715 and 646 admissions in the 30 months post-PCV10, respectively. Pneumonia hospitalizations declined by 37.8% (95% confidence interval [CI] 21.4–50.3%) and 28.8% (95% CI 17.7–38.7%) among children aged <1 year and 1–4 years, respectively, while meningitis hospitalizations declined by 72.1% (95% CI 63.2–79.0%) and 61.6% (95% CI 50.4–70.8%), respectively, in these age groups. In contrast, at the referral hospital, pneumonia hospitalizations remained stable and a smaller but significant decline in meningitis was observed among children aged 1–4 years (39.3%, 95% CI 16.2–57.5%).

Conclusions
PCV10 introduction was associated with declines in meningitis and pneumonia hospitalizations in Zambia, especially in first-level care hospitals.
Archival DNA reveals cryptic biodiversity within the Spotted Shag (Phalacrocorax punctatus) from New Zealand
Authors: Rawlence Nicolas J , Rayner Matt J , Lovegrove Tim G , Stoddart Debbie , Vermeulen Melanie , Easton Luke J , Tennyson Alan J D , Scofield R Paul , Kennedy Martyn , Spencer Hamish , Waters Jonathan M 
Published: May 2019

Abstract
Genetic data are increasingly being used to prioritize species conservation in a fiscally constrained age of seemingly boundless conservation crises. Such data can also reveal previously cryptic biodiversity requiring further revision of conservation management guidelines. Using a combination of mitochondrial (control region) and nuclear (beta fibrinogen intron 7) DNA, and morphology, we reveal that the endemic New Zealand Spotted Shag (Phalacrocorax punctatus) complex exhibits phylogenetic structure that is decoupled from previously recorded qualitative morphological variation. Crucially, the most genetically distinct populations within P. punctatus are from northern New Zealand; recent surveys show that these populations, which house important genetic diversity within Spotted Shags, are in danger of being extirpated. In contrast, we find the previously phenotypically differentiated nominate (P. punctatus punctatus) and Blue (P. punctatus oliveri) Shag subspecies show no genetic and morphological separation, and are of least conservation concern.
Learning and Mechanism Design: An Experimental Test of School Matching Mechanisms with Intergenerational Advice
Authors: Ding Tingting , Schotter Andrew 
Published: May 2019

Abstract
While the mechanisms that economists design are typically static, one-shot games, in the real world, mechanisms are used repeatedly by generations of agents who engage in them for a short period of time and then pass on advice to their successors. Hence, behaviour evolves via social learning and may diverge dramatically from that envisioned by the designer. We demonstrate that this is true of school matching mechanisms—even those for which truth-telling is a dominant strategy. Our results indicate that experience with an incentive-compatible mechanism may not foster truthful revelation if that experience is achieved via social learning.
Doping among high school students: findings from the French ESPAD survey
Authors: Shah Jalpa , Janssen Eric , Le Nézet Olivier , Spilka Stanislas 
Published: May 2019

AbstractBackgroundThe increasing use of doping by youth is a growing public health concern. The present study aimed to calculate robust estimates of the prevalence of doping among French high school students and study factors related to the use of licit vs. banned agents.MethodsThe European School Project on Alcohol and other Drugs (ESPAD), a nationally representative school-based survey, was distributed across France from April to May 2015, generating a final sample size of 6642 students. Multilevel modelling was used to examine covariates of doping to enhance athletic performance in sport in this population.ResultsOverall, 2.3% of students used banned agents, and 6.1% used licit and banned substances to improve athletic performance. Significant gender differences existed for both, with males more prone to doping than females. Our findings provide support for the existing gateway hypothesis that nutritional supplementation leads to doping banned agents. Multilevel modelling revealed the presence of both school and class-level influences on individual use of licit substances, vs. solely class-level factors impacting the use of banned agents, suggesting a strong peer-effect.ConclusionsThese findings support the need to engage in early doping prevention through high schools. Programmes should draw attention to the role of licit substances, including nutritional supplementation, in the progression to using banned agents and encompass the continuum of adolescent risk taking through a behaviour-based approach to doping prevention.
Population Genomic Signatures of Genetic Structure and Environmental Selection in the Catadromous Roughskin Sculpin Trachidermus fasciatus
Authors: Li Yu-Long , Xue Dong-Xiu , Zhang Bai-Dong , Liu Jin-Xian 
Published: May 2019

AbstractUnderstanding the patterns of genetic diversity and adaptation across species’ range is crucial to assess its long-term persistence and determine appropriate conservation measures. The impacts of human activities on the genetic diversity and genetic adaptation to heterogeneous environments remain poorly understood in the marine realm. The roughskin sculpin (Trachidermus fasciatus) is a small catadromous fish, and has been listed as a second-class state protected aquatic animal since 1988 in China. To elucidate the underlying mechanism of population genetic structuring and genetic adaptations to local environments, RAD tags were sequenced for 202 individuals in nine populations across the range of T. fasciatus in China. The pairwise FST values over 9,271 filtered SNPs were significant except that between Dongying and Weifang. All the genetic clustering analysis revealed significant population structure with high support for eight distinct genetic clusters. Both the minor allele frequency spectra and Ne estimations suggested extremely small Ne in some populations (e.g., Qinhuangdao, Rongcheng, Wendeng, and Qingdao), which might result from recent population bottleneck. The strong genetic structure can be partly attributed to genetic drift and habitat fragmentation, likely due to the anthropogenic activities. Annotations of candidate adaptive loci suggested that genes involved in metabolism, development, and osmoregulation were critical for adaptation to spatially heterogenous environment of local populations. In the context of anthropogenic activities and environmental change, results of the present population genomic work provided important contributions to the understanding of genetic differentiation and adaptation to changing environments.
The History of Medicine Meets Labour History: Miners’ Bodies in the Age of Industrialization
Authors: Bluma Lars 
Published: May 2019

Abstract
This article presents a survey of new approaches in German labour history that deal with the history of the body. It argues that Foucault’s conceptual and historical understanding of biopolitics enables a profound rearticulation of the history of industrial work and the process of industrialization. The article addresses, however, not only the possibilities of biopolitics but also its limitations for a reconceptualization of labour history. The methodical and theoretical discussion is linked to concrete research into the body history of German coal mining in the Ruhr.
Cognitively Intact and Happy Life Expectancy in the United States
Authors: Bardo Anthony R , Lynch Scott M 
Published: May 2019

Abstract

Objectives
We examined the number of years to be lived with and without cognitive impairment and with high self-assessed quality of life (i.e., happiness) among a nationally representative sample of Americans aged 65 years and older. Two key questions are addressed: Can people have a high quality of life despite being cognitively impaired? Which is longer: happy life expectancy or cognitively intact life expectancy?

Method
Data from nine waves of the Health and Retirement Study (1998–2014) were used to estimate transition probabilities into and out of cognitively intact/impaired-un/happy states, as well as to death. Recently extended Bayesian multistate life table methods were used to estimate age-specific cognitively intact and happy life expectancy net of sex, race/ethnicity, education, and birth cohort.

Results
Happiness and cognitive impairment were shown to coexist in both the gross cross-tabulated data and in the life tables. Happy life expectancy is approximately 25% longer than cognitively intact life expectancy at age 65 years, and by age 85, happy life expectancy is roughly double cognitively intact life expectancy, on average.

Discussion
Lack of cognitive impairment is not a necessary condition for happiness. In other words, people can have a high quality of life despite being cognitively impaired.
The impacts of decentralization on health system equity, efficiency and resilience: a realist synthesis of the evidence
Authors: Abimbola Seye , Baatiema Leonard , Bigdeli Maryam 
Published: May 2019

AbstractOne constant refrain in evaluations and reviews of decentralization is that the results are mixed. But given that decentralization is a complex intervention or phenomenon, what is more important is to generate evidence to inform implementation strategies. We therefore synthesized evidence from the literature to understand why, how and under what circumstances decentralization influences health system equity, efficiency and resilience. In doing this, we adopted the realist approach to evidence synthesis and included quantitative and qualitative studies in high-, low- and middle-income countries that assessed the the impact of decentralization on health systems. We searched the Medline and Embase databases via Ovid, and the Cochrane library of systematic reviews and included 51 studies with data from 25 countries. We identified three mechanisms through which decentralization impacts on health system equity, efficiency and resilience: ‘Voting with feet’ (reflecting how decentralization either exacerbates or assuages the existing patterns of inequities in the distribution of people, resources and outcomes in a jurisdiction); ‘Close to ground’ (reflecting how bringing governance closer to the people allows for use of local initiative, information, feedback, input and control); and ‘Watching the watchers’ (reflecting mutual accountability and support relations between multiple centres of governance which are multiplied by decentralization, involving governments at different levels and also community health committees and health boards). We also identified institutional, socio-economic and geographic contextual factors that influence each of these mechanisms. By moving beyond findings that the effects of decentralization on health systems and outcomes are mixed, this review presents mechanisms and contextual factors to which policymakers and implementers need to pay attention in their efforts to maximize the positive and minimize the negative impact of decentralized governance.
The Role of Water in Fast Plant Movements
Authors: Edwards J , Laskowski M , Baskin T I , Mitchell N , DeMeo B 
Published: May 2019

Abstract
Plants moved onto land ∼450 million years ago and faced their biggest challenge: living in a dry environment. Over the millennia plants have become masters of regulating water flow and the toolkit they have developed has been co-opted to effect rapid movements. Since plants are rooted, these fast movements are used to disperse reproductive propagules including spores, pollen, and seeds. We compare five plants to demonstrate three ways, used alone or in combination, that water powers rapid movements: the direct capture of the kinetic energy of a falling raindrop propels gemmae from the splash cups of the liverwort, Marchantia; the loss of water powers the explosive dispersal of the spores of Sphagnum moss; the alternate loss and gain of water in the bilayer of the elaters of Equisetum drive the walk, jump, and glide of spores; the gain of water in the inner layer of the arils of Oxalis drive the eversion of the aril that jettisons seeds from the capsule; and the buildup of turgor pressure in the petals and stamens of bunchberry dogwood (Cornus canadensis) explosively propels pollen. Each method is accompanied by morphological features, which facilitate water movement as a power source. The urn shaped splash cups of Marchantia allow dispersal of gemmae by multiple splashes. The air gun design of Sphagnum capsules results in a symmetrical impulse creating a vortex ring of spores. The elaters of Equisetum can unfurl while they are dropping from the plant, so that they capture updrafts and glide to new sites. The arils of Oxalis are designed like miniature toy “poppers.” Finally, in bunchberry, the softening of stamen filament tissue where it attaches to the anther allows them to function as miniature hinged catapults or trebuchets.
Multifunctional Structures and Multistructural Functions: Integration in the Evolution of Biomechanical Systems
Authors: Farina S C , Kane E A , Hernandez L P 
Published: May 2019

Abstract
Integration is an essential feature of complex biomechanical systems, with coordination and covariation occurring among and within structural components at time scales that vary from microseconds to deep evolutionary time. Integration has been suggested to both promote and constrain morphological evolution, and the effects of integration on the evolution of structure likely vary by system, clade, historical contingency, and time scale. In this introduction to the 2019 symposium “Multifunctional Structures and Multistructural Functions,” we discuss the role of integration among structures in the context of functional integration and multifunctionality. We highlight articles from this issue of Integrative and Comparative Biology that explore integration within and among kinematics, sensory and motor systems, physiological systems, developmental processes, morphometric dimensions, and biomechanical functions. From these myriad examples it is clear that integration can exist at multiple levels of organization that can interact with adjacent levels to result in complex patterns of structural and functional phenotypes. We conclude with a synthesis of major themes and potential future directions, particularly with respect to using multifunctionality, itself, as a trait in evolutionary analyses.
The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis
Authors: Ooi Brandon Nick Sern , Loh Huiwen , Ho Peh Joo , Milne Roger L , Giles Graham , Gao Chi , Kraft Peter , John Esther M , Swerdlow Anthony , Brenner Hermann , Wu Anna H , Haiman Christopher , Evans D Gareth , Zheng Wei , Fasching Peter A , Castelao Jose Esteban , Kwong Ava , Shen Xia , Czene Kamila , Hall Per , Dunning Alison , Easton Douglas , Hartman Mikael , Li Jingmei 
Published: May 2019

AbstractBackgroundEvidence linking breast size to breast cancer risk has been inconsistent, and its interpretation is often hampered by confounding factors such as body mass index (BMI). Here, we used linkage disequilibrium score regression and two-sample Mendelian randomization (MR) to examine the genetic associations between BMI, breast size and breast cancer risk.MethodsSummary-level genotype data from 23andMe, Inc (breast size, n = 33 790), the Breast Cancer Association Consortium (breast cancer risk, n = 228 951) and the Genetic Investigation of ANthropometric Traits (BMI, n = 183 507) were used for our analyses. In assessing causal relationships, four complementary MR techniques [inverse variance weighted (IVW), weighted median, weighted mode and MR-Egger regression] were used to test the robustness of the results.ResultsThe genetic correlation (rg) estimated between BMI and breast size was high (rg = 0.50, P = 3.89x10−43). All MR methods provided consistent evidence that higher genetically predicted BMI was associated with larger breast size [odds ratio (ORIVW): 2.06 (1.80–2.35), P = 1.38x10−26] and lower overall breast cancer risk [ORIVW: 0.81 (0.74–0.89), P = 9.44x10−6]. No evidence of a relationship between genetically predicted breast size and breast cancer risk was found except when using the weighted median and weighted mode methods, and only with oestrogen receptor (ER)-negative risk. There was no evidence of reverse causality in any of the analyses conducted (P > 0.050).ConclusionOur findings indicate a potential positive causal association between BMI and breast size and a potential negative causal association between BMI and breast cancer risk. We found no clear evidence for a direct relationship between breast size and breast cancer risk.
An Obstacle for Higher Regularity of Geodesics in the Space of Kähler Potentials
Authors: Hu Jingchen 
Published: May 2019

Abstract
In this paper we address the following question regarding the regularity of geodesics in the space of Kähler potentials. Given a geodesic that is highly regular, and has smooth boundary value, can we expect that it is actually smooth? We construct an example to show that the answer to the question is “no”.
Local cell coordination does not alter individual cell migration during collective migration but does impact cellular exchange events
Authors: Slater Benjamin , Ng Edwin , McGuigan Alison P 
Published: May 2019

Abstract
Coordinated cell re-organization is critical to ensure correct tissue morphogenesis for a number of important embryonic and tissue repair events, however the mechanisms that govern cells coordination during collective movements, particularly in situations where cells are spatially restricted by their neighbours, are not well understood. Here we assessed cell re-organization in monolayers of retinal epithelial cells (ARPE-19) to determine if cells that coordinate with their neighbours exhibit differential migration properties to non-coordinating cells and participate differently in local cell re-organization of the tissue sheet. From global tracking analysis, we determined that the movement profiles of cells were indistinguishable regardless of whether or not they were a part of multicellular streams. Using high magnification live imaging of cell membranes, we also characterized the localized geometry and organization of a monolayer (cell area, number of nearest neighbours, aspect ratio, internal cell angles) during cell re-organization in both streaming and non-streaming regions. Consistent with our global migration analysis, we observed no differences in cell sheet geometry and organization in streaming versus non-streaming regions. We did however observe that cells executed T1-like transitions to exchange position within the space-limited monolayer and that exchange events consistently involved at least one non-streaming cell. Our data suggests a model in which cell movement within the sheet is limited by neighbour exchange events and likely cells transition between streaming and non-streaming regimes to facilitate these neighbour exchange events while maintaining the integrity of the sheet.