bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naked eye three‐dimensional teaching assistant system applied to undergraduate medical imaging education: A pilot study
Authors: Ma Li‐Na , Peng Rui , Xu Jing‐Ji , Yang Qing‐Ling , Li A‐Ceng , Han Ye , Yuan Lei , Shen Fan , Yin Dan‐Qing , Zheng Min‐Wen , Huang Ya‐Yu , Ren Jing 
Published: December 2024

AbstractThe traditional approach of using PowerPoint (PPT) presentations in medical imaging theory classes hinders the spatial thinking ability of most students. Consequently, the learning outcomes are often unsatisfactory. This article proposes a naked eye three‐dimensional (3D) medical imaging teaching assistant app based on augmented reality (AR) technology to enhance learning interest, teaching interaction, and effectiveness. The control group consisted of 50 undergraduate students from the 2018 clinical medicine major who receive traditional teaching, while the experimental group includes 52 undergraduate students from the 2019 cohort who utilize an AR‐based naked eye 3D teaching assistant app in addition to traditional teaching methods. Based on Bloom's cognitive learning taxonomy (Remember, Understand, Apply, Analyze, Evaluate, and Create), corresponding teaching curricula and assessment methods were designed in order to achieve more in‐depth learning of the curriculum. The evaluation of the teaching effectiveness between the two groups relied on exam scores and student satisfaction questionnaires, with statistical analyses conducted using t‐test and Mann–Whitney U‐test in SPSS. The experimental group and control group showed statistically significant differences in the theoretical examination scores (62.06 ± 3.06 vs. 59.82 ± 3.38), practical testing scores (22.90 ± 2.35 vs. 21.06 ± 2.65), and total scores (84.96 ± 4.58 vs. 80.88 ± 6.01). Likert scores showed the experimental group scored significantly higher in enjoyment, satisfaction, participation, efficiency, and understanding. They also reported high convenience scores for the app and desired continued use. The naked eye 3D teaching assistant system is an innovative and effective teaching model for undergraduate medical imaging education, enhancing student interest, student interaction, and teaching effectiveness and promising future applications.
Influence of the boreal summer intraseasonal oscillation on temperature and precipitation in South Korea
Authors: Jung Yoo‐Rim , Lee Woo‐Seop 
Published: December 2024

AbstractThe boreal summer intraseasonal oscillation (BSISO) is a major mode of sub‐seasonal variability that regulates the summer climate in East Asia. This study investigates the four possible effects of two different time‐scale BSISOs on temperature and precipitation variations in South Korea. When active BSISO convection is positioned over the subtropical western Pacific, it induces anomalous anticyclonic circulation accompanied by subsidence, leading to significant positive temperature anomalies. Conversely, the anomalous cyclonic circulation near the Korean Peninsula, resulting from suppressed convection in the subtropical western Pacific, along with low‐level cold advection anomalies, contributes to a decrease in temperature. The spatial distribution of BSISO convection, which drives precipitation variation, shows a distinctive pattern of three meridionally narrow cells extending from the Philippines to the Korean Peninsula. Suppressed (enhanced) convection to the north of 20°N in the western North Pacific (WNP) promotes the northwestward expansion (eastward contraction) of the WNP Subtropical High in conjunction with a southwesterly (northeasterly) moisture flux anomaly. Furthermore, enhanced (reduced) moisture flux convergence and intensified ascending (descending) motion create favorable conditions for positive (negative) precipitation anomalies in South Korea. The combined effect of BSISOs not only amplifies the mean temperature and precipitation anomalies compared to individual modes but also increases the frequency of warmer, wetter, and drier events. Therefore, monitoring both BSISO modes together is crucial for comprehending and predicting the anomalous summer climate in South Korea.
Planung der neuen Gänstorbrücke in Ulm
Authors: Klähne Thomas , Sweers Bastian , Roth Timo 
Published: December 2024

AbstractDie neue Gänstorbrücke wird die von Ulrich Finsterwalder im Jahr 1950 errichtete Spannbetonrahmenbrücke über die Donau zwischen den Städten Ulm und Neu‐Ulm ersetzen. Der Bauwerksentwurf geht aus einem 2019/2020 ausgeschriebenen Realisierungswettbewerb hervor. Das geplante Bauwerk ist ein einfeldriges integrales Verbundrahmenbauwerk mit einer lichten Weite von 86,50 m und damit eines der längsten Bauwerke seiner Art in Deutschland. Es besteht aus zwei Teilbauwerken. Der Überbau jedes Teilbauwerks ist ein fünfzelliger Hohlkasten aus Stahl mit einer 25 cm dicken Stahlbetonplatte, der in tiefgegründete Widerlager eingespannt wird. In Anlehnung an die alte, als herausragendes Beispiel für die Ingenieurbaukunst geltende Spannbetonbrücke besticht der Entwurf durch sein schlankes Erscheinungsbild. Die große Schlankheit wird neben der Wahl des statischen Systems durch die Querschnitts‐ und Materialwahl sowie die Montagereihenfolge erreicht. Im Beitrag wird über die statische Konzeption, die Herstellung sowie die Planung maßgebender Details wie u. a. die Ausbildung der Rahmenecke und die Leitdetails des Stahlbaus berichtet. Dabei war die integrierte Planung des Stahl‐ und Massivbaus mithilfe von 3D‐Modellen in der Statik und Konstruktion von großem Vorteil.
F Doped δ‐MnO2 Nanoflowers for High‐Performance Aqueous Zinc‐Ion Batteries
Authors: Li Zhou , Ye Zhongqiang , Liu Guangzhan , Jiang Ziyan , Jiang Wenjia , Luo Junwei , Liu Shaoxiong , Hu Hai , Huang Zhifeng , Liu Li 
Published: December 2024

AbstractAqueous zinc‐ion batteries (AZIBs) have attracted significant attention from researchers in recent years due to their low cost, high safety and high theoretical capacity. Among them, δ‐MnO2 is considered one of the most promising cathode materials for aqueous zinc ion batteries because of its layered structure, which facilitates the intercalation and deintercalation of zinc ions. However, its narrow layer spacing and poor structural stability limit its future practical applications. To tackle these issues, herein, we report a two‐step strategy to introduce anionic fluoride ions into the δ‐MnO2 nanoflowers. The flower‐like spherical structure, composed of interspersed nanosheets, increases the active sites for electrochemical reactions. Fluorine doping can expand the interlayer spacing available for ion insertion/extraction, and the formed fluorine‐manganese chemical bonds could stabilize the manganese‐oxygen octahedral ([MnO6]) structure. The F‐doped δ‐MnO2 nanoflowers show a reversible capacity of 435.1 mAh g−1 at a current density of 0.1 A g−1, which is obviously higher than that of undoped δ‐MnO2 (212 mAh g−1). These results indicate the potential of anion introduction in enhancing the electrochemical performance of δ‐MnO2 in aqueous zinc‐ion batteries.
Ritual or Reform? Untangling the B Corp Certification Process From a Routines Perspective
Authors: Pedersen Esben Rahbek Gjerdrum , Andersen Kirsti Reitan , Pedersen Frederik Hovmark , Bjartmarz Thordis Katla 
Published: December 2024

ABSTRACTSeveral studies have focussed on the impacts of B Corp certification, whereas little attention has been rendered to the experiences of organisations undergoing the certification process. This study provides deeper insights into how managers perceive the B Corp certification process by focussing on the relationship between certification requirements and existing sustainability routines. Based on interviews with 26 B Corp certifying organisations, this study demonstrates how the certification process can inspire actions ranging from validation of existing practices to more deep‐rooted changes in sustainability routines. Moreover, the study highlights the internal organisational conditions, which shape the routine performances in relation to B Corp certification. It is concluded that regular revisits of the organisation's sustainability performance and the mobilisation of local actors in sustainability work promote routine changes. This study expands on sustainability certification discussions by demonstrating how these tools shape, and in turn are shaped by, dominant patterns of sustainability work within the organisation.
Reciprocal tumor‐platelet interaction through the EPHB1‐EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma
Authors: Yao Lin‐Li , Qin Wei‐Ting , Hu Li‐Peng , Shi Tie‐Zhu , Yu Yang Jian , Li Qing , Nie Hui‐Zhen , Li Jun , Wang Xu , Zhu Lei , Liu De‐Jun , Zhang Yan‐Li , Jiang Shu‐Heng , Zhang Zhi‐Gang , Yang Xiao‐Mei , Li Dong‐Xue , Zhang Xue‐Li 
Published: December 2024

AbstractBackgroundThe interaction between the metastatic microenvironment and tumor cells plays an important role in metastatic tumor formation. Platelets play pivotal roles in hematogenous cancer metastasis through tumor cell‐platelet interaction in blood vessels. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy distinguished by its notable tendency to metastasize to the liver. However, the role of platelet in the liver metastatic niche of PDAC remains elusive. This study aimed to elucidate the role of platelets and their interactions with tumor cells in the liver metastatic niche of PDAC.MethodsAn mCherry niche‐labeling system was established to identify cells in the liver metastatic niche of PDAC. Platelet depletion in a liver metastasis mouse model was used to observe the function of platelets in PDAC liver metastasis. Gain‐of‐function and loss‐of‐function of erythropoietin‐producing hepatocellular receptor B1 (Ephb1), tumor cell‐platelet adhesion, recombinant protein, and tryptophan hydroxylase 1 (Tph1)‐knockout mice were used to study the crosstalk between platelets and tumor cells in the liver metastatic niche.ResultsThe mCherry metastatic niche‐labeling system revealed the presence of activated platelets in the liver metastatic niche of PDAC patients. Platelet depletion decreased liver metastatic tumor growth in mice. Mechanistically, tumor cell‐expressed EPHB1 and platelet‐expressed Ephrin B1 (EFNB1) mediated contact‐dependent activation of platelets via reverse signaling‐mediated AKT signaling activation, and in turn, activated platelet‐released 5‐HT, further enhancing tumor growth.ConclusionWe revealed the crosstalk between platelets and tumor cells in the liver metastatic niche of PDAC. Reciprocal tumor‐platelet interaction mediated by the EPHB1‐EFNB1 reverse signaling promoted metastatic PDAC outgrowth via 5‐HT in the liver. Interfering the tumor‐platelet interaction by targeting the EPHB1‐EFNB1 axis may represent a promising therapeutic intervention for PDAC liver metastasis.
A Monitoring Tool for the Evaluation of Program Outcomes in Engineering Education
Authors: Yorulmaz Muhammet , Keçeci Barış , Tansel İç Yusuf , Gülşen Mehmet , Dengiz Berna 
Published: December 2024

ABSTRACTDuring the evaluation process, organizations that accredit engineering programs determine whether a program meets a list of predetermined criteria. One criterion on the list is Program Outcomes (POs). The most common weakness statement is found in this criterion. First, we aim to develop a model that can support program evaluation during the accreditation process. Second, the proposed approach can be used as a feedback tool in the continuous improvement of teaching in engineering programs. The course instructor runs the first module, which predefined learning outcomes and the POs are linked together using an Excel‐based software for each activity performed in the course. The second module calculates the scores that reflect the achievement levels of the POs for the whole program. The scores from individual courses are simultaneously transferred to the Technique for Order Preference by Similarity to Ideal Solution module that determines the rating scores of the POs in the program. The proposed system shows which POs are at a satisfactory level and which are lagging behind and need attention. It helps the course administrators to manage the course material proactively. The proposed system is a powerful tool for monitoring and tracking POs, and it is the primary tool used by program administrators to improve the program continuously. It is particularly useful in identifying the weak spots of the program. The successful implementation of the system in our department since 2012 makes us confident that the system could be adopted by other engineering programs.
Cerebrospinal Fluid Flow Cytometry in Pediatric Acute Lymphoblastic Leukemia: A Multicenter Retrospective Study in China
Authors: Tu Songji , Zhang Kunlong , Liu Chenzhu , Wang Ningling , Chu Jinhua , Yang Linhai , Xie Zhiwei , Hang Lingling , Li Jun , Yang Wenyu , Zhu Xiaofan 
Published: December 2024

ABSTRACTObjectiveThe central nervous system (CNS) is a frequent site of relapse in childhood acute lymphoblastic leukemia (ALL). This study aims to investigate the utility of cerebrospinal fluid (CSF) flow cytometry in detecting CNS infiltration and relapse.MethodsFlow cytometry was used to detect CSF leukemia cells, and patients were categorized into the CSF Flow+ and CSF Flow− groups. The primary outcome was the cumulative incidence of relapse (CIR) in the CSF Flow+ and CSF Flow− groups.ResultsA total of 1301 patients were enrolled, 159 patients (12.2%) showed positive CSF flow cytometry results. The CNS Flow+ patients exhibited significantly higher rates of any CNS relapse (22.5% vs. 0.2%, p < 0.01) and isolated CNS relapse (10.7% vs. 0%, p < 0.01) compared to CNS Flow− patients. Cox regression analysis revealed that risk factors for isolated CNS relapse included a positive result of D46 minimal residual disease (MRD) and CSF Flow+ at a non‐initial diagnosis. For any CNS relapse, the significant risk factors were CSF Flow+ at the initial diagnosis and CSF Flow+ at a non‐initial diagnosis.ConclusionsCSF flow cytometry may have clinical utility in detecting CNS infiltration among pediatric ALL patients. It could contribute to more effective risk stratification and treatment adjustments and potentially reduce the risk of CNS relapse.
The Evidence Effect: How Fact Boxes Shift Perceptions of Lung Cancer Screening in Austrian Medical Practice
Authors: Amelunxen Carolina , Bielecki Michel , Wegwarth Odette , Funk Georg‐Christian 
Published: December 2024

ABSTRACTBackgroundRecent results from the Dutch NELSON study have rekindled debates about the benefit‐to‐harm ratio of lung cancer screening and the comprehension of this by physicians.MethodsThis research surveyed the perception and understanding of 136 Austrian physicians regarding the advantages and risks of lung cancer screening, examining the impact of educational data visualization tools, including fact box and icon array. Physicians participated in an online survey about their understanding before and after exposure to either a fact box alone or combined with an icon array.ResultsThe findings indicated that the fact box significantly enhanced physicians' grasp of the screening's benefits and harms, making them up to 13 times more likely to adjust their estimates within a predefined range. Notably, the intervention was more effective among physicians who initially did not recommend CT screening. However, the addition of the icon array did not offer significant improvement. Postintervention, physicians showcased better comprehension and an improved ability to offer patient‐centered advice, which may bolster adherence to lung cancer screening protocols.OutlookDespite its insights, the study's cross‐sectional nature and the unique cultural context underline the need for more research. Further exploration should focus on different settings and assess the real‐world implications on clinical practice and patient outcomes.
Dual‐Phase Enhanced CT‐Derived Radiomics Nomogram for Progression‐Free Survival Prediction in Stage IV Lung Adenocarcinoma
Authors: Sun Haitao , Peng Zhaohui , Chen Guoyue , Dai Zhengjun , Yao Jian , Zhou Peng 
Published: December 2024

ABSTRACTPurposeThe objective is to establish a radiomics nomogram (Rad‐nomogram) using dual‐phase enhanced computed tomography (DPE‐CT) for the prediction of progression‐free survival (PFS) in patients diagnosed with stage IV lung adenocarcinoma (ADC).MethodsFrom DPE‐CT scans, radiomic characteristics were retrieved from 133 patients diagnosed with stage IV lung ADC. Clinical data were analyzed using univariate and multivariate Cox regression analyses. The radiomics signature was combined with clinical features employing multivariate Cox analysis in order to develop a Rad‐nomogram. The predictive efficiency of the nomogram was evaluated using survival studies, such as Kaplan–Meier curves and Harrell's C‐index. The benefits and clinical utility of various models were compared using the net reclassification index (NRI), decision curve analysis (DCA), and integrated discrimination improvement (IDI).ResultsIn the test cohort, the C‐indexes for the clinical, artery, and vein phase CT models were 0.675, 0.691, and 0.678, respectively. The dual‐phase achieved a C‐index of 0.731, exceeding the CT model, while the developed nomogram reached a C‐index of 0.783. The Kaplan–Meier survival study classified patients into low‐risk and high‐risk groups related to PFS using the Rad‐nomogram (p < 0.05). The Rad‐nomogram demonstrated a greater net advantage when compared with clinical and Rad models, as indicated by positive values of the NRI and IDI (ranging from 11.6% to 52.6%, p < 0.05).ConclusionThe Rad‐nomogram, employing DPE‐CT scans, offers a promising approach to predict PFS in individuals diagnosed with stage IV lung ADC.
Mitoxantrone‐Based Novel Conditioning Regimen Leads to Great Survival Benefit in Peripheral T‐Cell Lymphoma Compared to BEAM Regimen
Authors: Zuo Xinyu , Qian Wensi , Wu Min , Xie Yanhui , Ma Jiexian 
Published: December 2024

ABSTRACTBackgroundPeripheral T‐cell lymphomas (PTCL) frequently result in relapsed or refractory diseases. Upfront autologous hematopoietic stem cell transplantation (ASCT) using the BEAM (carmustine, etoposide, cytarabine, and melphalan) regimen is recommended. However, relapses are common in PTCL, highlighting a critical need for improved survival outcomes in these patients.ObjectiveAnthracycline drugs are essential in treating PTCL. We compared the efficacy and tolerability of a high‐dose mitoxantrone‐based conditioning regimen [mitoxantrone, cyclophosphamide, and etoposide (MCE)] to the BEAM regimen in upfront ASCT for newly diagnosed PTCL patients who achieved complete or partial remission after induction therapy.Study DesignA retrospective study was conducted to analyze the treatment response, progression‐free survival (PFS), overall survival (OS), hematologic engraftment time, and adverse events of 64 patients between two regimens, who achieved complete or partial remission after induction chemotherapy. Twenty‐eight patients received the MCE regimen, while 36 patients were treated with the BEAM regimen.ResultsThere were no significant differences in clinical characteristics or the incidence of adverse events between the two groups. However, the median OS significantly favored the MCE group at 102.4 (95% CI, 87.0–117.8) months compared to 62.6 (95% CI, 50.8–74.5) months in the BEAM group (p = 0.023). Similarly, the median PFS was longer in the MCE group at 87.8 (95% CI, 65.8–109.8) months versus 42.5 (95% CI, 30.0–55.0) months in the BEAM group (p = 0.031).ConclusionASCT with the mitoxantrone‐based conditioning regimen is tolerable and appears to significantly improve the prognosis of PTCL patients, offering a promising alternative to the current standard of care.
A Community Perspective on Boxing, Well‐being and Young People
Authors: Ryan Aoife , John Mary , Hanna Paul 
Published: December 2024

ABSTRACTCommunities possess various resources, such as sporting organisations, that establish positive relationships with young people whom statutory services may struggle to engage. Boxing has been shown to attract individuals from diverse cultural and socio‐economic backgrounds, offering proven benefits in areas such as physical health and engagement. When taking into consideration mental and physical well‐being, there is limited knowledge regarding the overall well‐being benefits of boxing for young people. This study adopts an ethnographic approach within an Inner London community boxing gym to investigate the well‐being benefits of boxing for young people. Qualitative interviews, field notes and observations were employed with young people, staff and volunteers. The community identified that boxing provided young people with a changed sense of self, engaged them in a recursive learning process and instilled a sense of belonging, like that of a new family. These factors can all be associated with well‐being. The study highlights the significance of community‐based resources, such as boxing gyms, in providing support for improving well‐being for a diverse cohort of young people. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement
Seaweed‐Derived Bioactive Compounds: Potent Modulators in Breast Cancer Therapy
Authors: Behera Maheswari , Singh Lakshmi , Pradhan Biswajita , Behera Kanhu Charan 
Published: December 2024

ABSTRACTCancer remains a major global health concern, with breast cancer being particularly challenging. To address this, new therapeutic strategies are being explored, including natural alternatives. Seaweeds, rich in bioactive compounds, have gained attention for their therapeutic potential. Traditionally valued for their nutritional content, seaweed‐derived compounds such as polysaccharides, polyphenols, sterols, vitamins, minerals, and carotenoids have shown anticancer properties. These compounds can modulate key cellular processes like apoptosis, angiogenesis, and inflammation—crucial in cancer progression. Their antioxidant, anti‐inflammatory, and immunomodulatory effects make them promising candidates for complementary cancer therapies. Key bioactive components like fucoidans, laminarins, phlorotannins, and carotenoids exhibit antiproliferative, proapoptotic, antiangiogenic, and antimetastatic properties. Recent studies focus on the ability of these compounds to induce apoptosis in cancer cells. This review highlights the chemical constituents of various seaweed species with antitumor activity, their mechanisms of action, and the potential for integration into cancer treatments. It also addresses challenges in clinical applications and outlines future research directions for leveraging these marine resources in breast cancer therapy.
Costus igneus: A Versatile Herbal Remedy for Multiple Health Conditions
Authors: Yadav Megha , Sahu Bhaskar , Sahu Mukesh 
Published: December 2024

ABSTRACTCostus igneus, commonly known as the insulin plant, is a potent medicinal herb with a wide range of pharmacological activities. Traditionally used in diabetes management, recent studies have highlighted its antidiabetic, antioxidant, antimicrobial, hepatoprotective, and kidney stone‐inhibitor properties. Phytochemical analyses reveal the presence of saponins, flavonoids, alkaloids, steroids, and terpenoids, which contribute to its therapeutic effects. In various in vitro and in vivo models, C. igneus demonstrated significant hypoglycemic activity. The plant exhibits strong antioxidant activity, as evidenced by FRAP, DPPH, and ABTS assays, with notable radical scavenging and reducing power. Other miscellaneous pharmacological activities include anti‐inflammatory, anti‐arthritic, cytotoxicity, and hypotensive effects. These findings support C. igneus as a safe and cost‐effective herbal remedy for managing diabetes and other ailments, highlighting its potential for future therapeutic applications and the development of herbal formulations.