bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of different proportions of knitting elements on the resistive properties of conductive fabrics
Authors: Liu Su , Liu Yanping , Li Li 
Published: April 2018

Conductive yarn is the key factor in fabricating electronic textiles. Generally, three basic fabric production methods (knit, woven, and non-woven) combined with two finishing processes (embroidery and print) are adopted to embed conductive yarns into fabrics to achieve flexible electronic textiles. Conductive yarns with knit structure are the most flexible and effective form of electronic textiles. Electronic textiles present many advantages over conventional electronics. However, in the process of commercialization of conductive knitted fabrics, it is a great challenge to control the complicated resistive networks in conductive knitted fabrics for the purpose of cost saving and good esthetics. The resistive networks in conductive knitted fabrics contain length-related resistance and contact resistance. The physical forms of conductive yarns in different fabrication structures can be very different and, thus, the contact resistance varies greatly in different fabrics. So far, study of controlling the resistive property of conductive fabrics has not been conducted. Therefore, establishing a systematic method for the industry as a reference source to produce wearable electronics is in great demand. During the industrialization of conductive knitted fabrics, engineers can estimate the resistive property of the fabric in advance, which makes the production process more effective and cost efficient. What is more, the resistive distribution in the same area of knitted fabrics can be fully controlled.
Acquired infection during neonatal and pediatric extracorporeal membrane oxygenation
Authors: Cashen Katherine , Reeder Ron , Dalton Heidi J. , Berg Robert A. , Shanley Thomas P. , Newth Christopher J. L. , Pollack Murray M. , Wessel David , Carcillo Joseph , Harrison Rick , Dean J. Michael , Tamburro Robert , Meert Kathleen L 
Published: April 2018

Introduction: Our objectives are to (1) describe the pathogens, site, timing and risk factors for acquired infection during neonatal and pediatric ECMO and (2) explore the association between acquired infection and mortality. Methods: Secondary analysis of prospective data collected by the Collaborative Pediatric Critical Care Research Network between December 2012 and September 2014. Clinical factors associated with acquired infection were assessed with multivariable Cox regression. Factors associated with mortality were assessed with logistic regression. Results: Of 481 patients, 247 (51.3%) were neonates and 400 (83.2%) received venoarterial ECMO. Eighty (16.6%) patients acquired one or more infections during ECMO; 60 (12.5%) patients had bacterial, 21 (4.4%) had fungal and 11 (2.3%) had viral infections. The site of infection included respiratory for 53 (11.0%) patients, bloodstream for 21 (4.4%), urine for 20 (4.2%) and other for 7 (1.5%). Candida species were most common. Median time to infection was 5.2 days (IQR 2.3, 9.6). On multivariable analysis, a greater number of procedures for ECMO cannula placement was independently associated with increased risk of acquired infection during ECMO (Hazard Ratio 2.13 (95% CI 1.22, 3.72), p<0.01) and receiving ECMO in a neonatal ICU compared to a pediatric or cardiac ICU was associated with decreased risk (Hazard Ratio pediatric ICU 4.25 (95% CI 2.20, 8.20), cardiac ICU 2.91 (95% CI 1.48, 5.71), neonatal ICU as reference, p<0.001). Acquired infection was not independently associated with mortality. Conclusion: ECMO procedures and location may contribute to acquired infection risk; however, acquired infection did not predict mortality in this study.
Risk factors to predict leg ischemia in patients undergoing single femoral artery cannulation in minimally invasive cardiac surgery
Authors: Tarui Tatsuya , Miyata Kazuto , Shigematsu Sayaka , Watanabe Go 
Published: April 2018

Background: In peripheral cannulation for cardiopulmonary bypass, there is always a risk of ischemia in the extremities, caused by femoral artery cannulation. This report aimed to evaluate the outcome and the risk factors in patients undergoing minimally invasive cardiac surgery in mitral valve surgery. Methods: We retrospectively reviewed all minimally invasive mitral valve surgery at our institute from May 2014 to December 2016. Operative outcomes and intra-operative monitoring for distal leg saturation were measured by the near-infrared spectroscopy values. For post-operative outcomes, the creatinine phosphorus kinase level was measured for the assessment of leg ischemia. Risk factors were evaluated for the elevation of post-operative creatinine phosphorus kinase. Results: There were 162 patients who underwent single femoral artery cannulation for minimally invasive mitral valve surgery. The mean operation, cardiopulmonary bypass and aortic cross-clamp time were 212±44, 124±30, 76.6±22 minutes (min), respectively. The factors related to increased creatinine phosphorus kinase were male, body mass index, larger cannula size, operation time, cardiopulmonary bypass time and aortic cross-clamp time. The measurement of minimum near-infrared spectroscopy values did not show any association with creatinine phosphorus kinase elevation. There were significant associations between body mass index, cannula size and operation time and post-operative creatinine phosphorus kinase increase by multiple regression analysis. Two male patients had extremely high post-operative creatinine phosphorus kinase (18188 U/L and 16831 U/L) and they had high body mass index, large cannula size and longer operation time. Conclusions: In peripheral cannulation for minimally invasive cardiac surgery, body mass index, cannula size and operation time can be considered as risk factors for leg ischemia.
A pilot investigation of a mobile phone application and progressive reminder system to improve adherence to daily prevention treatment in adolescents and young adults with migraine
Authors: Ramsey Rachelle R , Holbein Christina E , Powers Scott W , Hershey Andrew D , Kabbouche Marielle A , O'Brien Hope L , Kacperski Joanne , Shepard Jeffrey , Hommel Kevin A 
Published: April 2018

Background Effective management of migraine requires adherence to treatment recommendations; however, adolescents with migraine take their daily medications only 75% of the time. Low-cost adherence-focused interventions using technology may improve adherence, but have not been investigated. Methods Thirty-five adolescents and young adults (13–21 years) with migraine participated in an AB-design pilot study to assess the use of a mobile phone adherence-promotion application (“app”) and progressive reminder system. Adherence was calculated using electronic monitoring during the baseline period and medication adherence intervention. Results Relative to baseline, adherence significantly improved during the first month of the intervention. Specifically, improvements existed for older participants with lower baseline adherence. Self-reported app-based adherence rates were significantly lower than electronically monitored adherence rates. Participants rated the intervention as acceptable and easy to use. Conclusions “Apps” have the potential to improve medication adherence and are a promising intervention for adolescents and young adults with low adherence. Involving parents in the intervention is also helpful. Providers should assess barriers to adherence and use of technology-based interventions, encourage parents to incorporate behavioral incentives, and provide referrals for more intensive interventions to improve long-term outcomes. Further, tracking adherence in an app may result in an underestimation of adherence. Future full-scale studies should be conducted to examine adherence promotion app interventions.
Chronorisk in cluster headache: A tool for individualised therapy?
Authors: Barloese Mads , Haddock Bryan , Lund Nunu T , Petersen Anja , Jensen Rigmor 
Published: April 2018

Background The mechanisms behind the severe pain of cluster headache remain enigmatic. A distinguishing feature of the attacks is the striking rhythms with which they occur. We investigated whether statistical modelling can be used to describe 24-hour attack distributions and identify differences between subgroups. Methods Common hours of attacks for 351 cluster headache patients were collected. Probability distributions of attacks throughout the day (chronorisk) was calculated. These 24-hour distributions were analysed with a multimodal Gaussian fit identifying periods of elevated attack risk and a spectral analysis identifying oscillations in risk. Results The Gaussian model fit for the chronorisk distribution for all patients reporting diurnal rhythmicity (n = 286) had a goodness of fit R2 value of 0.97 and identified three times of increased risk peaking at 21:41, 02:02 and 06:23 hours. In subgroups, three to five modes of increased risk were found and goodness of fit values ranged from 0.85–0.99. Spectral analysis revealed multiple distinct oscillation frequencies in chronorisk in subgroups including a dominant circadian oscillation in episodic patients and an ultradian in chronic. Conclusions Chronorisk in cluster headache can be characterised as a sum of individual, timed events of increased risk, each having a Gaussian distribution. In episodic cluster headache, attacks follow a circadian rhythmicity whereas, in the chronic variant, ultradian oscillations are dominant reflecting a loss of association with sleep and perhaps explaining observed differences in the effects of specific treatments. The results demonstrate the ability to accurately model chronobiological patterns in a primary headache.
Massive Pulmonary Infarction during Total Cardiopulmonary Bypass in Unanesthetized Spontaneously Breathing Lambs
Authors: Kolobow T. , Spragg R.G. , Pierce J.E. 
Published: April 2018

We provided total cardiopulmonary support for 1-18 hours in unanesthetized tethered lambs by peripheral vascular cannulation, using a roller pump and the spiral membrane lung. Respirations were allowed to remain spontaneous and unaided. A Swan-Ganz catheter was placed for retrograde pulmonary artery blood flow sampling. Within a few minutes following induced ventricular fibrillation the PCO2 of sampled blood flowing retrograde through the lungs fell below 10 mm Hg, the PO2 rose to near 150 mm Hg, the pH rose to above 7.8, and the glucose level fell to less than 20 mg %. All of these values later gradually shifted, approaching mixed venous blood values within minutes. After 1-18 hrs of perfusion the animals went into shock and were sacrificed. At autopsy, the lungs of animals breathing room air were beefy and hemorrhagic. In lambs that were «breathing» CO2 enriched air the retrograde pulmonary artery blood pH and PCO2 was usually maintained close to the mixed venous blood values. The observed pulmonary changes were considerably less abnormal, and the microscopic abnormalities were at times nonexistent. We believe the integrity of pulmonary blood flow is vital to the survival of the lungs as a functioning organ. Cessation of total forward pulmonary blood flow (unlike partial cardiopulmonary bypass), combined with spontaneous pulmonary ventilation, rapidly leads to massive, pulmonary infactions, shock, and death.
In vivo Hemoperfusion Studies of Bilirubin Removal from Jaundiced Dogs
Authors: Thaler L. Mor. I. , Brandes J.M. , Sideman S. 
Published: April 2018

Removal of bilirubin by hemoperfusion (HP) on a macroreticular ion-exchange resin is suggested as a novel clinical procedure for the treatment of jaundiced newborn babies. The efficiency and biocompatibility of the proposed macroreticular (MR) ion exchange column was tested in vivo with jaundiced dogs. An animal model with a choledocho-suprarenal vein shunting allowed to test the column capacity for the adsorption of conjugated and unconjugated bilirubin. A second animal model, based on infusing unconjugated bilirubin directly into the blood stream, enabled to test the column operation at desired unconjugated bilirubin concentrations. The results of the in vivo hemoperfusion tests are very encouraging and compare favorably with bilirubin removal from babies by exchange transfusion (ET). Operating a column containing 10 ml resin per kg body weight for 3 hours removed over 1.7 times the initial unconjugated bilirubin content. Furthermore, the animals seemed to be unaffected by the HP procedure; the changes due to hemoperfusion on blood chemistry, hematology and some hormone levels were practically insignificant.
Complications of Subclavian Catheter Hemodialysis: A 5 Year Prospective Study in 257 Consecutive Patients
Authors: Vanholder R. , Lameire N. , Verbanck J. , Van Rattinghe R. , Kunnen M. , Ringoir S. 
Published: April 2018

The complications related to the use of subclavian catheters for hemodialysis were prospectively studied in 257 consecutive acute and chronic renal failure patients. Using 394 catheters, 3006 single needle dialyses were performed. Indications for starting catheter dialysis were mainly the absence or disappearance of an adequate vascular access. Most hazardous complications were sepsis (9), malposition (6), hemothorax (3), bleeding (2), vena cava thrombosis (2) and pneumothorax (2). A number of mechanical problems occurred, where the obstructed catheter could easily be replaced by a modified Seldinger technique. No mortal complications occurred. Patient tolerance was excellent. It is concluded that single needle subclavian hemodialysis is a valuable alternative vascular access method in acute situations. It enables the continuation of hemodialysis on an ambulatory basis.
Long-term Cytapheresis in the Treatment of Sézary-syndrome
Authors: Müller N. , Lange C.-E. 
Published: April 2018

Lymphocytaphereses using the Fenwal CS 3000 cell separator were performed in three patients with far advanced disease of Sézary-syndrome that was refractory to standard form of therapy. Patients underwent cytapheresis two to three times per week until the WBCs counts were regressed. Thereafter, one pheresis per week was performed for a total of 29 (Pat. A), 18 (Pat. B) to 70 (Pat. C) procedures during periods of 13 (A), 4 (B) to 19 (C) months. During each pheresis the volume of blood processed was 6-7000 mls. The cytaphereses resulted in an average WBCs reduction of 25 to 35% and of 35-56% of the original peripheral blood Sézary-cell counts. Lymphocytes counts dropped by 47 ± 12% and 87 to 95% of the collected cells were lymphocytes. In addition to the fall in absolute numbers of circulating lymphocytes a change in the relative portions of lymphocytes subpopulations was observed. T-cells were reduced and concurrently B-cells increased. Significant side effects did not occured during or following cytaphereses. Long-term pheresis can effectively treat symptmoms also in older patients resulting in preferential loss of T-cells and Sézary-cells without exposing the patients to dangerously large shifts in fluid volume. The results suggest also that there may be selected patients for whom lymphocytapheresis is an useful therapy, but no in vitro test can reliably separate responders from non-responders, and some patients become refractory to further cytapheresis-therapy after initial clinical remission. While cytapheresis does not appear to be sufficient as a sole therapeutic modality in this disease, it may be for some patients, if initiated early in the course of the disorder, result in clinical improvement. It may also be safely used even when the peripheral WBCs count is normal and for some patients there appears to be additive benefit of the procedure.
In vitro Complement-Independent Activation of Human Neutrophils by Hemodialysis Membranes: Role of the Net Electric Charge
Authors: Tetta C. , Segoloni G. , Camussi G. , Neumann S. , Griva S. , Piva S. , Pacitti A. , Vercellone A. 
Published: April 2018

Polymethylmethacrylate (PMMA) membranes with different net electric charges and percentage water contents (anionic 71%, neutral 70%, cationic 75%) were evaluated for their ability to stimulate plasma-free human polymorphonuclear neutrophils (PMN), and compared for potency to cuprophan (Cu), already described as being a potent trigger of PMN. The release of lysozyme, β-glucuronidase, lactic dehydrogenase (LDH), and the generation of a platelet aggregating activity were studied in the supernatants from plasma-free human PMN incubated with different membranes. The PMN intracellular content of neutrophil cationic proteins (NCP), elastase, and cathepsin G were also studied by immunofluorescence using specific antisera on smears of PMN before and after incubation with each membrane. Only cationic, but not anionic or neutral PMMA induced a marked release of lysozyme (range 20-25% of the sonicated control, assumed as 100%), and β-glu-coronidase (40-43%), and marked depletion of the intracellular content of NCP, elastase, and cathepsin G, suggesting a degranulation process. Platelet aggregating activity was generated and referred to the release of platelet activating factor (PAF) only in the supernatants from PMN incubated with cationic, but not with anionic, or neutral PMMA membranes. These results indicate that modification of the net electric charge can per se turn PMMA, commonly recognized as inert, into a material with marked PMN activating effects, comparable to those of Cu, a highly reactive polymer.
Inorganic Phosphate Removal during Different Dialytic Procedures
Authors: Zucchelli P. , Santoro A. 
Published: April 2018

In order to clarify the influence of membrane surface, membrane composition, dialysate buffer and convective transfer on the dialytic removal of inorganic phosphate (Pi), 11 uremic patients were studied. Each patient underwent 7 different dialysis techniques: conventional hemodialysis with acetate buffer and different surface or composition of the membrane, bicarbonate dialysis and a “soft” hemodiafiltration, also termed biofiltration, with post-dilution infusion of 4 liters. The treatment time was fixed at 4 hours. Our study showed that the dialyzer surface area and the ultrafiltration rate were the major factors in dialytic inorganic phosphorus (Pi) removal. The dialysate buffer does not modify dialytic Pi removal but may influence the rebound phenomenon.
Hyperprolactinemia as a Marker of Neurotransmitter Imbalance in Uremic Population
Authors: Biasioli S. , D'Andrea G. , Micieli G. , Feriani M. , Borin D. , Chiaramonte S. , Cananzi A. , La Greca G. 
Published: April 2018

Serum prolactin (PRL) levels are elevated in patients with chronic renal failure (CRF) but the mechanisms responsible for these abnormalities are not fully understood. PRL secretion is undoubtedly influenced by many substances, which can be variously altered in uremia: monoamines, endogenous opiates and PTH. Our data suggest that in early renal failure PRL levels are already significantly high and the 24-h pattern of PRL secretion is significantly different from that in controls. PRL derangements could be due in mild renal failure, to unknown factors (GABA?); in severe CRF, to a major change in dopaminergic activity; in hemodialysis (HD), to a low turnover of monoamines, and in peritoneal dialysis (PD) to increased activity of sero-toninergic and dopaminergic systems.
Does Immunodeficiency in Uremic Patients Promote Dialysis-Related Amyloidosis?
Authors: Simon P. , Ang K.S. , Cavarle Y. , Cam G. , Catheline M. , Genetet N. 
Published: April 2018

The present study was undertaken to evaluate the immune function of 5 hemodialysis patients with dialysis-related amyloidosis as compared to 6 without, both groups having a dialytic age from 7 to 21 years, and 5 healthy controls. We investigated serum levels of immunoglobulins (IgG, IgA, IgM), made skin tests and measured peripheral lymphocyte subsets using monoclonal antibodies. 1) The absolute numbers of T3, T4 and T8 cells were significantly lower in hemodialysis patients than controls and T3, T4 cells were lower in patients with amyloidosis than in those without: T3 (m ± SD/μl), 387 ± 253 vs 744 ± 207 (p = 0.03); T4, 262 ± 115 vs 589 ± 297 (p = 0.04). 2) Serum levels of IgG and IgM were significantly lower in patients with amyloidosis than in the others: IgG (m ± SD, g/l), 10.2 ± 1.4 vs 15.4 ± 3.2 (p < 0.001); IgM, 0.65 ± 0.28 vs 1.65 ± 0.37 (p < 0.001). 3) Delayed hypersensitivity studied by skin tests showed less than 3 positive antigens in 4/5 patients with amyloidosis against 1/6 patients without. These data suggest there is a marked defect of T-cell help in uremic patients with dialysis-related amyloidosis.
Hemodynamic and Energetic Assessment of Calves Implanted with a Left Ventricular Assist Device (LVAD)
Authors: Pantalos G.M. , Marks J.D. , Riebman J.B. , Burton N.A. , Depaulis R. , Kolff W.J. 
Published: April 2018

Hemodynamic and ventricular energetic parameters were measured in calves implanted with the air driven Utah Ventricular Assist Device (UVAD). Uptake site was varied to determine the effect of control mode and vacuum augmentation of filling. Uptake was drawn solely from the left atrium or combined with a left ventricular apical vent. LVAD outflow returned to the descending, thoracic aorta. Control modes examined included asynchronous pumping as well as 1:1 and 1:2 synchronous diastolic counterpulsation. The 85cc LVAD, vacuum formed from PELLETHANE®, was implanted acutely in four animals and chronically in six (7, 49 and 116 days paracorporeally, 1, 28 and 32 days intrathoracically). Instantaneous blood pressures, intramyocardial pressure, aortic outflow, oxygen consumption, LVAD output and drive parameters were recorded. LVAD output was independent of control mode when the natural heart rate was ≥ 80 beats per minute. Intrathoracically positioned LVADs pumped a mean flow of ≈5 liters/min without vacuum augmentation of filling. Paracorporeally positioned LVADs pumped ≈3 liters/min mean flow without vacuum augmentation and up to ≈6 liters/min with 38 mm Hg of vacuum augmentation of filling. Instantaneous ascending aortic pressure and flow showed distinct beat-to-beat variation depending on LVAD control mode. Lower average ventricular afterload was observed when pumping the LVAD asynchronously or 1:2 synchronously. In one acute preparation, left ventricular myocardial oxygen consumption was reduced from the unassisted average control level by 37% for the asynchronous and 1:1 synchronous control modes with left atrial uptake. With combined uptake, oxygen consumption was reduced an additional 30% during asynchronous control or 11% during 1:1 synchronous control without any change in LVAD output. Endocardial/epicardial blood flow ratio was similar and ≥1.12 for all test conditions. Renal and brain blood flow was maintained, or slightly elevated during ventricular assistance. Intramyocardial pressures were monitored using Millar catheter tip transducers. In an acute preparation, left ventricular assistance reduced peak intramyocardial pressure. Changing from atrial to combined uptake cannulation further reduced peak intramyocardial pressure for asynchronous and 1:1 synchronous LVAD control. Reduced end-diastolic intramyocardial pressures were seen with all modes of LVAD control. These data demonstrate excellent UVAD pumping function and suggest that left ventricular assistance does not compromise endocardial blood flow while sustaining blood flow to other major organs. Regardless of the uptake site, asynchronous or 1:2 synchronous LVAD control may be clinically preferable for effective reduction of left ventricular myocardial oxygen consumption.