bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technical Note: Deep learning based MRAC using rapid ultrashort echo time imaging
Authors: Jang Hyungseok , Liu Fang , Zhao Gengyan , Bradshaw Tyler , McMillan Alan B. 
Published: May 2018

PurposeIn this study, we explore the feasibility of a novel framework for MR‐based attenuation correction for PET/MR imaging based on deep learning via convolutional neural networks, which enables fully automated and robust estimation of a pseudo CT image based on ultrashort echo time (UTE), fat, and water images obtained by a rapid MR acquisition.MethodsMR images for MRAC are acquired using dual echo ramped hybrid encoding (dRHE), where both UTE and out‐of‐phase echo images are obtained within a short single acquisition (35 s). Tissue labeling of air, soft tissue, and bone in the UTE image is accomplished via a deep learning network that was pre‐trained with T1‐weighted MR images. UTE images are used as input to the network, which was trained using labels derived from co‐registered CT images. The tissue labels estimated by deep learning are refined by a conditional random field based correction. The soft tissue labels are further separated into fat and water components using the two‐point Dixon method. The estimated bone, air, fat, and water images are then assigned appropriate Hounsfield units, resulting in a pseudo CT image for PET attenuation correction. To evaluate the proposed MRAC method, PET/MR imaging of the head was performed on eight human subjects, where Dice similarity coefficients of the estimated tissue labels and relative PET errors were evaluated through comparison to a registered CT image.ResultDice coefficients for air (within the head), soft tissue, and bone labels were 0.76 ± 0.03, 0.96 ± 0.006, and 0.88 ± 0.01. In PET quantitation, the proposed MRAC method produced relative PET errors less than 1% within most brain regions.ConclusionThe proposed MRAC method utilizing deep learning with transfer learning and an efficient dRHE acquisition enables reliable PET quantitation with accurate and rapid pseudo CT generation.
Effects of Gizzard Shad Reduction on Relative Abundance, Growth, and Body Condition of Bluegills and Largemouth Bass in a Small Kansas Impoundment
Authors: Neely Ben C. , Koch Jeff D. , Lynott Sean T. 
Published: May 2018

Abstract
Gizzard Shad Dorosoma cepedianum are commonly manipulated as a prey species in the United States but are widely viewed as undesirable in small impoundments because of direct and indirect effects on desirable sport fishes. Montgomery State Fishing Lake in southeastern Kansas became populated with Gizzard Shad during a flood event in 2007, and subsequent monitoring efforts indicated the Bluegill Lepomis macrochirus population was negatively affected. Remedial action involving reservoir dewatering and application of rotenone (target concentration of 7.5 μg/L) was conducted during the winter of 2013–2014, and responses of Bluegills and Largemouth Bass Micropterus salmoides were monitored for 3 years posttreatment. Gizzard Shad were not extirpated following treatment, but their relative abundance decreased 99.8%. Relative abundance of age-0 Bluegills and Largemouth Bass immediately increased following treatment in 2014 but decreased to pretreatment levels in 2015 and 2016. Conversely, growth of age-0 Bluegills decreased in 2014, but increased to pretreatment levels in 2015 and 2016. Growth of age-0 Largemouth Bass slightly decreased following treatment. Growth between the development of the second and third annulus did not differ among years for either species. Body condition of stock-length Bluegills and stock-length Largemouth Bass was greatest in 2012 but declined in subsequent years. These results suggest that, contrary to previously published studies, the reduction of Gizzard Shad had minimal effect on Bluegill and Largemouth Bass populations in Montgomery State Fishing Lake. However, intraspecific, density-dependent functions might have masked true responses of Bluegill and Largemouth Bass growth and body condition to Gizzard Shad reduction. Managers should understand that Gizzard Shad removal or reduction can have variable effects in aquatic systems and should be cognizant of potential outcomes and how those might affect fish populations and associated fisheries.
Modified Calix[4]crowns as Molecular Receptors for Barium
Authors: Steinberg Janine , Bauer David , Reissig Falco , Köckerling Martin , Pietzsch Hans‐Jürgen , Mamat Constantin 
Published: May 2018

AbstractA series of modified calix[4]crown‐6 derivatives was synthesized to chelate the heavy group 2 metal barium, which serves as a non‐radioactive surrogate for radium‐223/‐224; radionuclides with promising properties for radiopharmaceutical use. These calixcrowns were functionalized with either cyclic amide moieties or with deprotonizable groups, and the corresponding barium complexes were synthesized. Stability constants of these complexes were measured by using NMR and UV/Vis titration techniques to determine logK values of >4.1. Further extraction studies were performed to characterize the binding affinity of calixcrowns to radioactive barium‐133. Additionally, the ligands containing cyclic amides were investigated regarding their rotational barriers by using temperature‐dependent NMR measurements.
Modular photoinduced grafting onto approach by ketene chemistry
Authors: Alkan Goksu Yonca , Kumbaraci Volkan , Yagci Yusuf 
Published: May 2018

ABSTRACTA modular approach for the synthesis of graft copolymers by the combination of reversible addition–fragmentation chain‐transfer (RAFT) polymerization and photoinduced acylation processes is described. In the two‐step approach, first the copolymers of benzodioxinone containing monomer, namely, 4‐oxo‐2,2‐diphenyl‐4H‐benzo[d][1,3]dioxin‐7‐yl methacrylate (BDMA) and methyl methacrylate (MMA) in different feed ratios were prepared by RAFT polymerization. In the subsequent step, dichloromethane solutions of these copolymers (PMMA‐co‐PBDMA) were irradiated at λ = 300 nm in the presence of independently prepared hydroxyl functional polymers such as poly(ethylene glycol) (MeO‐PEG‐OH) and poly(ɛ‐caprolactone) (PCL‐OH). Side‐chain esterification reaction between photochemically generated ketene groups and hydroxyl functionalities resulted in the formation graft copolymers. The intermediates and final graft copolymers were characterized by 1H NMR, UV, IR, fluorescence, and GPC measurements. The success of the process was also confirmed by a model reaction using pyrene methanol. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 274–280
Toward flexible and antibacterial piezoresistive porous devices for wound dressing and motion detectors
Authors: da Silva Fernando A. G. , de Araújo Clisman M. S. , Alcaraz‐Espinoza Jose J. , de Oliveira Helinando P. 
Published: May 2018

ABSTRACTWearable and antibacterial porous devices are promising new multifunctional materials with a wide range of applications in wound dressing and human motion monitoring systems. The deposition of carbon nanotubes and polypyrrole coating on conventional elastomers (polyurethane) is a single‐step procedure that results in a low‐cost, highly conductive, and flexible piezoresistive material with pressure sensitivity of 0.09 kPa−1, Gauge Factor of −10.3, high stability in response to different mechanical efforts and reversible netlike microcracks formation under moderate stretching deformation. The resulting porous material provides direct detection of simple movements from human joints (knee, finger, and elbow) and intrinsic antibacterial activity against Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018, 56, 1063–1072
Benchmarking DFT methods on linear and nonlinear electric properties of spatially confined molecules
Authors: Chołuj Marta , Kozłowska Justyna , Bartkowiak Wojciech 
Published: May 2018

AbstractThe accurate evaluation of molecular electric properties still constitutes a challenge for density functional theory (DFT) methods. Moreover, some new issues appear, within this area of research, that require analysis. One of them concerns the electric properties of confined matter. This study aims at a quantitative evaluation of the performance of DFT framework in the description of dipole moment, polarizability, and first hyperpolarizability of the isolated and spatially confined molecules. The calculations were performed using a set of 35 exchange‐correlation functionals. The reference data were determined employing the highly accurate CCSD(T) method. To mimic the effect of spatial confinement the cylindrically symmetric harmonic oscillator potential was applied. Based on the conducted research it was found that the behavior of the considered functionals substantially differs depending on the studied electric property and molecule. Moreover, it was observed that the strength of spatial confinement strongly influences the performance of DFT methods.
Robot‐assisted total hip arthroplasty: Clinical outcomes and complication rate
Authors: Perets Itay , Walsh John P. , Close Mary R. , Mu Brian H. , Yuen Leslie C. , Domb Benjamin G. 
Published: May 2018

AbstractBackgroundThe purpose of this study was to report minimum 2‐year outcomes and complications for robotic‐arm‐assisted total hip arthroplasty (THA).MethodsData were prospectively collected and retrospectively reviewed between June 2011 and April 2014. Inclusion criteria were primary robotic‐arm‐assisted THAs treating idiopathic osteoarthritis with ≥ 2‐year follow‐up. Demographics, operating time, complications, 2‐year outcome scores and satisfaction, and subsequent surgeries were recorded.ResultsThere were 181 cases eligible for inclusion, of which 162 (89.5%) had minimum 2‐year follow‐up. At the latest follow‐up, the mean visual analogue scale was 0.7, satisfaction was 9.3, Harris hip score was 91.1 and forgotten joint score was 83.1. Six (3.7%) intraoperative complications and six (3.7%) postoperative complications were reported. No leg length discrepancies (LLDs) or dislocations were reported.ConclusionsRobotic‐arm‐assisted THA demonstrates favourable short‐term outcomes and does not result in a higher complication rate compared to non‐robotic THA as reported by the literature.
Congenital Zika syndrome: Pitfalls in the placental barrier
Authors: Robinson Nia , Mayorquin Galvan Evangelina E. , Zavala Trujillo Isidro G. , Zavala‐Cerna Maria G. 
Published: May 2018

SummaryMuch progress with respect to congenital Zika virus (ZIKV) pathogenesis has been achieved after the 2015 outbreak in Brazil. It is now accepted that ZIKV is vertically transmitted, infects cells of the developing central nervous system and the placenta, yet it is unclear to what extent placental affection contributes to the development of congenital ZIKV. The association between fulminant villitis and severe fetal involvement emerges as a possibility. ZIKV is unique among the Flaviviruses in its ability to be sexually transmitted, possibly responsible for its teratogenicity. Furthermore, there is controversy over the participation of antibody dependent enhancement (ADE) in patients with non‐neutralizing anti‐Flavivirus antibodies, a phenomenon previously recognized in serious DENV infections. Our aim was to analyze information regarding the contribution of the placental barrier as an actual player in neonatal ZIKV. Therefore, we underwent a systematic review with keywords “Zika virus” and “ZIKV”. Articles were screened for relevance concerning the topics of microcephaly, transplacental transmission, sexual transmission, and ADE. We identified variables that affect the severity of congenital Zika syndrome: age of gestation at maternal infection, the extent of placental disruption (villitis), sexual transmission, initial viral replication at the uterine wall, anti‐DENV antibodies, and the possibility of antibody‐mediated transcytosis of ZIKV through the placenta. These questions may not seem relevant when Zika becomes endemic, and we are no longer witness to the extreme clinical sequelae seen when the virus moves through an immunologically naïve population; however, characterizing the pathogenesis of congenital Zika syndrome will continue to further our understanding.
Photo‐Induced Polymerization and Reconfigurable Assembly of Multifunctional Ferrocene‐Tyrosine
Authors: Yang Xuejiao , Wang Yuefei , Qi Wei , Zhang Jiaxing , Zhang Liwei , Huang Renliang , Su Rongxin , He Zhimin 
Published: May 2018

AbstractThe photo‐induced reconfigurable assembly of nanostructures via the simultaneous noncovalent and covalent polymerization of a functional ferrocene‐tyrosine (Fc‐Y) molecule is reported. The Fc‐Y monomers can directly self‐assemble into nanospheres with a smooth surface driven by noncovalent interactions. By covalent photo‐crosslinking of the Fc‐Y monomers, the nanospheres transform spontaneously into hollow vesicles composed of hierarchically ordered lamellar structures. It is worth noting that the formed nanostructures exhibit both reducing property for in situ mineralization of gold nanoparticles with tunable biocatalytic behavior, and the redox activity for superior energy storage capacity. The measured energy storage capacity is 31 mAh g−1 for the nanospheres, which is the highest value reported so far for peptide assemblages as supercapacitor. The results offer insights into the dynamic self‐assembly of highly ordered multifunctional materials with promising applications in catalysis, sensing, energy and biomedical fields.
Metropolitan intelligent surveillance systems for urban areas by harnessing IoT and edge computing paradigms
Authors: Dautov Rustem , Distefano Salvatore , Bruneo Dario , Longo Francesco , Merlino Giovanni , Puliafito Antonio , Buyya Rajkumar 
Published: May 2018

SummaryRecent technological advances led to the rapid and uncontrolled proliferation of intelligent surveillance systems (ISSs), serving to supervise urban areas. Driven by pressing public safety and security requirements, modern cities are being transformed into tangled cyber‐physical environments, consisting of numerous heterogeneous ISSs under different administrative domains with low or no capabilities for reuse and interaction. This isolated pattern renders itself unsustainable in city‐wide scenarios that typically require to aggregate, manage, and process multiple video streams continuously generated by distributed ISS sources. A coordinated approach is therefore required to enable an interoperable ISS for metropolitan areas, facilitating technological sustainability to prevent network bandwidth saturation. To meet these requirements, this paper combines several approaches and technologies, namely the Internet of Things, cloud computing, edge computing and big data, into a common framework to enable a unified approach to implementing an ISS at an urban scale, thus paving the way for the metropolitan intelligent surveillance system (MISS). The proposed solution aims to push data management and processing tasks as close to data sources as possible, thus increasing performance and security levels that are usually critical to surveillance systems. To demonstrate the feasibility and the effectiveness of this approach, the paper presents a case study based on a distributed ISS scenario in a crowded urban area, implemented on clustered edge devices that are able to off‐load tasks in a “horizontal” manner in the context of the developed MISS framework. As demonstrated by the initial experiments, the MISS prototype is able to obtain face recognition results 8 times faster compared with the traditional off‐loading pattern, where processing tasks are pushed “vertically” to the cloud.
Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction
Authors: Duan Yaqian , Beli Eleni , Li Calzi Sergio , Quigley Judith L. , Miller Rehae C. , Moldovan Leni , Feng Dongni , Salazar Tatiana E. , Hazra Sugata , Al-Sabah Jude , Chalam Kakarla V. , Phuong Trinh Thao Le , Meroueh Marya , Markel Troy A. , Murray Matthew C. , Vyas Ruchi J. , Boulton Michael E. , Parsons-Wingerter Patricia , Oudit Gavin Y. , Obukhov Alexander G. , Grant Maria B. 
Published: May 2018

Abstract
Angiotensin-converting enzyme 2 (ACE2) is the primary enzyme of the vasoprotective axis of the renin angiotensin system (RAS). We tested the hypothesis that loss of ACE2 would exacerbate diabetic retinopathy by promoting bone marrow dysfunction. ACE2–/y were crossed with Akita mice, a model of type 1 diabetes. When comparing the bone marrow of the ACE2–/y-Akita mice to that of Akita mice, we observed a reduction of both short-term and long-term repopulating hematopoietic stem cells, a shift of hematopoiesis toward myelopoiesis, and an impairment of lineage–c-kit+ hematopoietic stem/progenitor cell (HS/PC) migration and proliferation. Migratory and proliferative dysfunction of these cells was corrected by exposure to angiotensin-1-7 (Ang-1-7), the protective peptide generated by ACE2. Over the duration of diabetes examined, ACE2 deficiency led to progressive reduction in electrical responses assessed by electroretinography and to increases in neural infarcts observed by fundus photography. Compared with Akita mice, ACE2–/y-Akita at 9-months of diabetes showed an increased number of acellular capillaries indicative of more severe diabetic retinopathy. In diabetic and control human subjects, CD34+ cells, a key bone marrow HS/PC population, were assessed for changes in mRNA levels for MAS, the receptor for Ang-1-7. Levels were highest in CD34+ cells from diabetics without retinopathy. Higher serum Ang-1-7 levels predicted protection from development of retinopathy in diabetics. Treatment with Ang-1-7 or alamandine restored the impaired migration function of CD34+ cells from subjects with retinopathy. These data support that activation of the protective RAS within HS/PCs may represents a therapeutic strategy for prevention of diabetic retinopathy.
RETRACTED ARTICLE: Adiponectin administration alleviates DSS-induced colonic inflammation in Caco-2 cells and mice
Authors: Zhao Qin , Liu Yang , Tan Lei , Yan Liyong , Zuo Xiuli 
Published: May 2018

Abstract
Background
Adiponectin, a protein hormone produced by adipose tissues, exhibits anti-inflammatory functions in various models. This study was investigated the effects of adiponectin on dextran sodium sulfate (DSS)-colonic injury, inflammation, apoptosis, and intestinal barrier dysfunction in Caco-2 cell and mice.

Materials and methods
The results showed that DSS caused inflammatory response and intestinal barrier dysfunction in vitro and in vivo. Adiponectin injection alleviated colonic injury and rectal bleeding in mice. Meanwhile, adiponectin downregulated colonic IL-1β and TNF-α expressions and regulated apoptosis relative genes to attenuate DSS-induced colonic inflammation and apoptosis. Adiponectin markedly reduced serum lipopolysaccharide concentration, a biomarker for intestinal integrity, and enhanced colonic expression of tight junctions (ZO-1 and occludin). The in vitro data further demonstrated that adiponectin alleviated DSS-induced proinflammatory cytokines production and the increased permeability in Caco-2 cells.

Conclusion
Adiponectin plays a beneficial role in DSS-induced inflammation via alleviating apoptosis and improving intestinal barrier integrity.
Lateral directional parameter estimation of a miniature unmanned aerial vehicle using maximum likelihood and Neural Gauss Newton methods
Authors: Saderla Subrahmanyam , Rajaram Dhayalan , Ghosh A. K. 
Published: May 2018

ABSTRACTThe current research paper describes the lateral-directional parameter estimation from flight data of a miniature Unmanned Aerial Vehicle (UAV) using Maximum Likelihood (ML), and Neural-Gauss-Newton (NGN) methods. An unmanned configuration with a cropped delta planform and thin rectangular cross-section has been designed, fabricated and instrumented. Exhaustive full-scale wind-tunnel tests were performed on the UAV to extract the form of aerodynamic model that has to be postulated a priori for parameter estimation. Rigorous flight tests have been performed to acquire the flight data for several prescribed manoeuvres. Four sets of compatible flight data have been used to carry out parameter estimation using classical ML and neural-network-based NGN methods. It is observed that the estimated parameters are consistent and the lower values of the Cramer-Rao bound for the corresponding estimates have shown significant confidence in the obtained parameters. Furthermore, to validate the aerodynamic model used and to enhance the confidence in the estimated parameters, a proof of match exercise has been carried out.
Procedural sedation by advanced care paramedics for emergency gastrointestinal endoscopy
Authors: Wiemer Hana M. , Butler Michael B. , Froese Patrick C. , Lapierre Allan , Carriere Chris , Etsell Glen R. , Farina Dana , Jones Jennifer , Murray Jock , Campbell Samuel G. 
Published: May 2018

AbstractObjectivesAt the QEII Health Sciences Centre Emergency Department (ED) in Halifax, Nova Scotia, advanced care paramedics (ACPs) perform procedural sedation and analgesia (PSA) for many indications, including orthopedic procedures. We have begun using ACPs as sedationists for emergent upper gastrointestinal (UGI) endoscopy. This study compares ACP-performed ED PSA for UGI endoscopy and orthopedic procedures in terms of adverse events, airway intervention, vasopressor requirement, and PSA medication use.MethodsA data set was built from an ED PSA quality control database matching 61 UGI endoscopy PSAs to 183 orthopedic PSAs by propensity scores calculated using age, gender, and the American Society of Anesthesiologists (ASA) classification. Outcomes assessed were hypotension (systolic BP<100 mm Hg or a 15% decrease from baseline), hypoxia (SaO2<90%), apnea (>30 sec), vomiting, arrhythmias, death, airway intervention, vasopressor requirement, and PSA medication use.ResultsUGI endoscopy patients experienced hypotension more frequently than orthopedic patients (OR=4.11, CI: 2.05-8.22) and required airway repositioning less often (OR=0.24, CI: 0.10-0.59). They received ketamine more frequently (OR=15.7, CI: 4.75-67.7) and fentanyl less often (OR=0.30, CI: 0.15-0.63) than orthopedic patients. Four endoscopy patients received phenylephrine, and one required intubation. No patient died in either group.ConclusionsIn ACP-led sedation for UGI endoscopy and orthopedic procedures, adverse events were rare with the notable exception of hypotension, which was more frequent in the endoscopy group. Only endoscopy patients required vasopressor treatment and intubation. We provide preliminary evidence that ACPs can manage ED PSA for emergent UGI endoscopy, although priorities must shift from pain control to hemodynamic optimization.