bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contributo All'Interpretazione delle Reazioni Nucleari delle Cellule Neopastiche alle Radiazioni Ionizzanti in Carcinomi della Portio
Authors: Pisani Giovanni , Marchetti Roberto 
Published: April 2018

Researches have been carried out with the « cariologic » method on portio carcinomas treated by radiumtherapy, in order to study the behaviour of tumour cells nuclei under the action of ionizing radiations. It has been noticed that: 1) A total descruction of all neoplastic cells may be obtained with doses of 9600 mgrh. 2) The number of « A » nuclei is markedly reduced already during the first phases of radiumtherapy, while the hypochromatic « B » nuclei and the picnotic ones increase at first and then disappear. The possibility is admitted that ionizing radiations may determine the transformation of A cells in B cells and picnotic elements following genoma alterations as well as a radical deviation of the nucleo- proteic metabolism. The hypothesis is presented that the nuclear phenomena, characteristic of the irradiated cells, may depend on the same process of altered synthesis of nucleic acids.
RICERCHE SPERIMENTALI CIRCA GLI EFFETTI DELL'IPOFISECTOMIA SULL'ATTECCHIMENTO E SULLA CRESCITA DEL TUMORE TRAPIANTABILE DI WALKER DEL RATTO
Authors: Rock T. , Rabotti G. C. 
Published: April 2018

I - In 5 hypophysectomized rats the curve of body weight was observed: the changes from the 10 th to the 30 th day after operation were unsignificant. II - 30 hypophysectomized rats were inoculated with Walker carcinoma and 30 normal rats were likewise inoculated and kept as controls. No statistical valuable difference in the positive taking of the transplants was observed. III - Tumor growth (measured by the weight as well as by the volume of tumours) was reduced by about one third in the hypophysectomized rats in comparison to the controls: a positive influence of the hypophysis on tumour growth may be admitted. IV - The hypophysis is not essential for the taking of the transplant, but exerts an influence in the following growth period.
Risultati Ottenuti Con La Roentgenterapia Preoperatoria in 343 Casi Di Carcinoma Della Mammella
Authors: Pisani Giovanni , Malaspina Adalberto 
Published: April 2018

343 patients with mammary carcinoma at the I, II and III stage according to Steinthal have been treated by pre-operatory roentgentherapy in the Cancer Department of Novara (from 1-1-1939 to 31-12-1949) Results are referred. The following percentages of survival free of symptomatology were obtained. 5 years after operation: 2,3 per cent for all the patients under observation (343); 65 per cent for the patients at the I and II stage according to Steinthal (245); 24,5 per cent for those at the III stage or intermediate between the II and III stage. 10 years after operation: 37 per cent for all patients without consideration of the stage (135); 48 per cent for those at the I and II stage according to Steinthal (95); 10 per cent for those at the II stage or intermediate between the II and III stage.
La Struttura Delle Proteine Epatiche in Corso Di Cancerogenesi Da P-Dimetilaminoazobenzene: Osservazioni Viscosimetriche e Denaturazione Da Urea
Authors: Lado P. , Rabotti G. C. 
Published: April 2018

The viscosimetric behaviour of three protein fractions from liver has been studied in 4 groups of rats (normal rats, rats fed Cantero diet alone, Cantero diet + DAB, rats bearing developed hepatoma). The treated rats were sacrificed at different times from the beginning of treatment. The protein fractions were obtained from 3 subsequent extractions from liver and from hepatoma: 1) 0,9 per cent NaCl solution buffered with phosphates (pH 7). 2) 10 per cent NaCl solution (pH 6,25). 3) 0,2 per cent NaOH solution (pH 12). The starting point of these researches is to be looked for in the conception supported by Rondoni that the cell cancerization does not represent a chemical modification at the atomic level but rather an architectural modification of protoplasmatic macromolecules, of their configuration and of intermolecular relation at supermolecular and ultrastructural level. The following conclusions may be drawn: I) A decrease of total N content has been observed in the liver during hepatomas formation. Some hypothesis on this subject are advanced, basing upon N distribution in the three groups of the examined proteins. II) In the four animal groups no significant viscosimetric differences have been observed in the protein extracts in saline solution and in NaCl. III) A significant increase in viscosity has been observed for the nucleoprotein fraction extracted by sodium hydrate: such increase is progressive in the treated animals and reaches the highest value in those bearing hepatomas. The altered viscosity is likely ascribable to a structural alteration of some protein or nucleoprotein macromolecules (denaturation or polymerization) of liver cells during carcinogenesis. IV) The viscosimetric determinations have been repeated after denaturation of the protein solution by urea: concordant results have been observed in the 4 groups of animals as concerns the obtained fractions. After treatment, the viscosimetric behaviour confirms the presence of globular proteins in the first fraction and filamentous proteins in the second one. In the third fraction, proteins having globular behaviour are observed, likely due to the splitting of the filamentous structure brought about by sodium hydrate.
Influenza Dell'ormone Somatotropo Sulla Crescita dei Fibroblasti di Cuore di Embrione di Pollo « in Vitro »
Authors: Valerio Monesi 
Published: April 2018

The effect of the somatotropic hormone on the « in vitro » growth of explants from chick embryos are studied. According to literature data, it would be suggested that the peripheral effects of the somatotropic hormone (diabetogenous and growth promoting effect) may be indirect, that is related, at least in part, to the glucagone secretion. Aim of the present study is the demonstration of a possible direct action of the hypophyseal growth hormone. The growth was determined by micrometric meauserements of the migration area of explants in 4 days old cultures. A 26,98 per cent growth increase was exerted by STH at a concentration of 1/1.000.000, no action at a concentration of 1/200.000 and a 33,11 per cent growth inhibition at a concentration of 1/100.000. The apparently paradoxical action of high doses could be likely related to the glycoinhibiting effect of the growth hormone (prevention of glucokinase reaction). Such effect may be subliminal with low doses, which would therefore demonstrate only the growth promoting action (stimulation of the protein anabolism); with increased doses it would reach the sensitivity threshold of the cell by abolishing at first and by inverting later the hormone activity.
I. - Indagini Sul Metabolismo di Fosforo Nucleinico di Tumori da Trapianto - Inibizione da Tiopirimidine
Authors: Di Marco A. , Gaetani M. , Necco A. , Polvani F. , Silvestrini R. 
Published: April 2018

Our previous researches made evident the inhibiting action of a pyrimidine analogue (2-thio-5-methylcytosine) on the growth of some experimental tumors. Therefore an investigation has been carried out in order to study wheter an inhibition of nucleic acid synthesis is associated with the tumor growth inhibition. The ARG technique, or stripping technique, has been employed with 32P as tracer element. The research has been carried out on rats bearing Walker carcinosarcoma and treated with 2-thio-5-methylcytosine. The employed ARG technique, which shows only the 32P bound to nucleic acids, allows also a quantitative evaluation of radiophosphorus uptake in those tumor areas showing a more active growth and no necrosis. In addition it gives evidence to the presence, in treated tumors, of areas histologicall unaltered which do not take up radiophosphorus. In the group of the treated tumors the 32P uptake was found to be the 17 per cent lower than in the controls, 24 hours already after the drug administration. A further decrease is observed following subsequent administrations. Forty eight hours after the drug injection the values of 32P uptake show an increase and overcome even those of the controls (+21 per cent). The values of mitotic coefficients parallel those of 32P uptake. In the intestinal mucosa of the treated animals both 32P uptake and the mitotic coefficient are found to be unmodified during the treatment and somewhat diminished after it as expression of a cumulative effect of the drug.
Effetti Del Trattamento Con Metilnaftochinoni Ed Acido Feniletilacetico Sullo Sviluppo Del Sarcoma Galliera Del Ratto
Authors: Montini T. , Prussia G. 
Published: April 2018

Data on the importance of sterols in the biochemism of tumour cells are briefly exposed, particularly as concerns the enhanced cholesterol turnover of the cell. An investigation has been carried out on the effects of a substance enhancing the endogenous biosynthesis (methylnaphthoquinone) and of a compound inhibiting it (phenylethylacetic acid). In rats the naphthoquinone derivatives with vitamin activity were found to stimulate the development rate of sarcoma Galliera. As for phenylethylacetic acid, microscopical ponderal data did not show any action.
In Tema Di Poliblastomatosi Maligna: Epitelioma del Pene Associato a Carcinoma Dello Stomaco
Authors: Grampa Giuseppe 
Published: April 2018

A short account on malignant polyblastomatosis is given and a case of epithelioma of the penis associated with gastric carcinoma in a luetic man 48 years old is described. A lung metastasis from the penis epithelioma and liver, lymph nodes, pleura, microscopic lung metastases from the gastric carcinoma were present. The presence of lung metastases from both tumours is pointed out as a contribution to the knowledge of multiple tumours metastases; the interest of the lung metastasis from a cancer of the penis more than 1 year after radical surgery is emphasized. The occurrence of the cancer of the penis may have been favoured by syphilis, which cannot be regarded as a predisposing factor to the polyblastomatosis.
Biochimica Dei Tessuti Iperplastici: Modificazioni Del Metabolismo Cellulare Indotte Dalla Rigenerazione Epatica
Authors: Pileri A. , Camurati P. , Gavosto F. 
Published: April 2018

The dynamic cell processes connected with liver regeneration have been studied as follows: 1) ribonucleic and desoxyribonucleic contents; 2) transamination reactions (glutamic-oxalacetic transaminase and glutamic-piruvic transaminase); 3) reactions related to the peptides constitution and demolition (dipeptidase); 4) reactions involved in the hydrolytic release of phosphoric bounds (alkaline phosphomonoesterase, acid pyrophosphatase, gluco-6-phosphatase); 5) reactions entering in nucleotides splitting and formation (nucleotidase). It has been particularly observed that the metabolic differences between normal and regenerating liver are mainly quantitative and that the enhancement of proteosynthesis does not necessarily imply a simultaneous enhancement of all the related biochemical activities.
Tossicologia Generale Di Alcuni Derivati Pirimidinici: 2-Tiocitosina E 2-Tio-5-Metilcitosina
Authors: Barbieri P. , Bertazzoli C. , Di Marco A. , Fuoco L. , Turolla E. 
Published: April 2018

The antitumour activity of some pyrimidine thio-derivatives has been studied simultaneously with their chronic toxic action. 2-thiocytosine (showing a rapid and nearly total urinary elimination), subcutaneously injected to rats in dose of 100 mg/kg for 39 times consecutively, induces only a slight reduction of erythrocytes and leukocytes in the circulating blood, with relative lymphocytopenia and moderate increase in leukocyte fragility, whereas the values of basal metabolism and weight curve are unmodified. From a morphological standpoint, the only valuable data are a slight stimulus towards neutrophils maturation and a similarly slight lymphoid hyperplasia in the lymph nodes. 2-thio-5-methylcytosine, subcutaneously injected at the same dose for 11 times consecutively, causes a remarkable mortality rate and inhibition of the body growth. Furthermore, differential blood count inversion, increased fragility of withe blood cells and inhibition of the first stages of erythropoiesis with stimulus towards neutrophils maturation are observed. The morphological changes are mainly characterized by nuclear degenerations of the reticuloendothelial system, which are particularly manifest in the spleen and may lead to cell death and, consequently, to reduction of the cellular density. As concerns the urinary elimination, in this case the 22 per cent only of the administered dose is recovered in urines. The changes induced by both the experimented pyrimidine derivatives, and especially by 2-thio-5-methylcytosine, are compared with those referred to in the literature concerning antimetabolic products.
Sul Comportamento Di Alcune Prove Di Funzionalita’ Epatica in Presenza Di Carcinoma Metastatico Del Fegato
Authors: Forni Mario 
Published: April 2018

In a group of patients with malignant tumours localized to different segments of the digestive canal and metastases clinically confined to liver only, the following findings have been constantly observed: increase of the serum alkaline phosphatase level, bilirubinemia levels below the higher normal limit, rise of the serum bromsulfalein retention, normal colloid lability tests and unchanged blood lipid fractions. Such a combination of values would in reality speak for a metastatic invasion of the liver, apart from unfrequent and well identifiable exceptions. An adequate evaluation of such results would give more precise indications for an early diagnosis of liver metastases and allow more exact criteria of operability as concerns the primary tumour. Further valuable data are given by gradual increase of alkaline hyperphosphatasemia and bromsulfalein retention, with normal bilirubinemia.
LE Sieroglicoproteine in Pazienti Affetti da Neoplasie Maligne
Authors: Bernasconi C. , Buscarini L. 
Published: April 2018

In serum of patients with cancers the variations of the electrophoretic pattern of proteins (hypoalbuminemia, hyper-alpha-2- and hyper-gamma-globulinemia) are accompanied by a deviated behaviour of the protein-bound carbohydrates: hyperglycoproteinemia (with an almost parallel increase of hexose, hexosamine and sialic acid levels) caused by an elevation of the carbohydrate percentage in the alpha-1 and alpha-2-globulins. As to evaluate the clinical interest of such alterations, which do not show any difference in the various neoplastic localisations, the Authors examinate their importance in the diagnosis of cancers, study their behaviour regarding to diffusions and metastatisation of the disease, and follow their changes in respect to therapy.
IL Sieroprotidogramma su Carta in Topi C3H Portatori di Adenocarcinomi Mammari Spontanei e di Sarcomi Indotti e Trapiantati
Authors: Bergonzi F. , Fantoni P. A. 
Published: April 2018

A study with paper electrophoresis has been carried out in mice of the C3H strain in different conditions of tumour growth: 1) growth of spontaneous tumours; 2) growth of induced tumours; 3) growth of transplants of induced tumours. Differences in the various groups have been statistically analyzed. All the seroprotidograms of animals bearing spontaneous mammary tumours show uncoupling of the alpha 2 fraction, whereas this is less frequently observed in induced and transplanted tumours, and still less in the controls. The seroprotidograms of mice bearing induced tumours show a marked increase of the alpha 2 fraction, and a less marked increase of the beta-fraction. The transplanted tumours, which have partly regressed, show values of serum proteins intermediate between those of mice in which the tumour has taken and those of the corresponding controls. In the « taken » transplants, the diminution, of the albumins, and the increase of alpha 1, alpha 2, beta and gamma globulins go gradually along with the neoplastic proliferation, except for a final fall of gammaglobulins and a tendency to normalization one month after transplantation; this fact is observed also in the group of the regressed transplants. The alpha 1 fractions is higher in the animals in which the transplant has taken than in those bearing induced tumours.
Attecchimento E Sviluppo Del Tumore Ascite Di Ehrlich E Del Sarcoma 180 in Topi con Nanismo Ipofisario
Authors: Turolla E. 
Published: April 2018

Some data of the literature point out that a growth hormone lack, due to hypophysectomy, can interfere on the onset and development of carcinogen induced and transplantable tumours. The data regarding the experiments on pituitary dwarf mice, in which 20 methylcholantrene induced epithelioma develop in a lower percentage than normal animals, seem particularly interesting. The present investigation was carried out on 24 dwarf mice and on their phenotipically normal litter mates, by transplanting the Ehrlich ascites tumour and sarcoma 180 both in solid or ascitic form. Body weight increase at the 8th and 15th day from tumour transplantation, survival time, and weight, morphological and histological features of tumours have been considered. The results show that the take and growth of tumours behave in quite similar manner both in dwarfs and in normal controls. The conclusion is then reached that for the studied tumours no growth hormone dependance exists. The differences in hormone dependance between transplantable tumours and the ones induced by chemical carcinogens are briefly discussed.
Ricerche Istochimiche Sui Linfonodi Laterocervicali Del Coniglio Dopo Irradiazione Con Gli Elettroni Veloci Del Betatrone
Authors: Magri M. , Cassin G. Cesati 
Published: April 2018

Histochemical researches were carried out in order to visualize nucleic acids and mucopolysaccharides in laterocervical lymph nodes of the rabbit, after irradiation with fast electrons by a 33 Mev betatron. Histochemical changes were found only with rather high dosages. The behaviour of nucleic acids showed a decrease in DNA which was more marked when the administered dose as higher. With regard to mucopolysaccharides, a decrease in the Alcian-positivity was observed, and an increase of the PAS positivity in comparison with the controls, especially with highest dosage.
Medical Oncology and Home Care in Italy
Authors: Terzoli Edmondo , Garufi Carlo , Ranuzzi Mario , Saso Umberto , Nisticò Cecilia 
Published: April 2018

Aims and Background Home care programs are designed to provide care for cancer patients in their homes. Aim of the study is to describe the activities of home care program, to examine the organization and efficiency of this type of care in Italy. Methods A questionnaire was sent to the regional representatives of the National Society of Medical Oncology and to the regional health departments. Results a) the home care program is uniformly distributed throughout the country; b) the number of personnel in the different centers varies greatly from one area to another; c) approximately 50 % of the centers do not cover emergency situations (at night or on holidays); and d) there is little involvement of the public sector. Conclusions In spite of these problems, the home care system is taking on a fundamental role, especially for advanced cancer patients.
A Phase II Study of Combination Chemotherapy in Advanced Ovarian Carcinoma with Cisplatin and Cyclophosphamide plus Reduced Glutathione as Potential Protective Agent against Cisplatin Toxicity
Authors: Locatelli Maria Cristina , D'Antona Adelaide , Labianca Roberto , Vinci Maria , Tedeschi Michele , Carcione Rosario , Corbo Antonello , Venturino Paola , Luporini Gino 
Published: April 2018

Aims and Backgroud The clinical use of cisplatin (CDDP)„ one of the most active agents in advanced ovarian cancer, is limited by nephrotoxicity and cumulative neurotoxicity. In preclinical studies, reduced glutathione (GSH) demonstrated a protective action against CDDP nephrotoxicity. We treated 20 patients with advanced ovarian carcinoma, with polichemotherapy containing CDDP + GSH, to assess the protective action of GSH against CDDP nephrotoxicity. Methods Between January 1988 and December 1989, 20 patients, with advanced ovarian carcinoma (St. III-IV-FIGO), not pretreated received CDDP: 45 mg/m2 i.v., on day 1-2, + cyclophosphamide (CPA): 900 mg/m2 i.v. on day 2 + GSH 2500 mg i.v. in normal saline 100 ml (in 15 min), before CDDP, every 21-28 days. Results A pathologic complete response rate (PCR) of 55 % (11/20) was observed (7/14 patients with bulky disease). Median survival was 26.5 months and 5 patients were still alive and disease free at 35 months. Toxicity was limited, without any case of nephrotoxicity. Conclusions On the basis of our previous experience with the same regimen without GSH, this study suggests that also in the clinical setting, GSH has no negative interference on CDDP activity and that GSH might improve the therapeutic index of CDDP. However, our data need to be confirmed by large randomized clinical studies.
Primary Carcinoma of the Fallopian Tube
Authors: Frigerio Luigi , Pirondini Alfredo , Pileri Massimo , Pifarotti Giorgio , Busci Luisa , Rabaiotti Emanuela , Ferrari Augusto 
Published: April 2018

Background Because of the rarity of fallopian tubecancer, clinical approaches have changed during the last 18 years. Methods Twenty-nine patients with fallopian tube cancer were treated at the Gynecologic Oncology Department of Milan University from 1970 to 1988. The mean patient age was 59 years. Parity, symptomatology and histology were considered. Distribution by stage was as follows: I, 11 (37 %); II, 10 (34 %); III, 8 (27%) according to the Dodson classification. Twenty patients (69 %) underwent surgery followed by pelvic irradiation. Adjuvant chemotherapy was performed in the treatment of 5 women with stage I disease, 6 with stage II, and all 8 with stage III. Results Five-year overall survival was 41.38 %: 47.6% at stages I and II, 25% at stage III. Radiotherapy has not been replaced by cisplatin-based multiagent chemotherapy. Optimal surgical debulking combined with accurate lymph node sampling are not followed by systematic use of repeat laparotomy. Conclusions The procedures described in this work improve the clinical assessment and patient survival, and make different series comparable.
Concurrent Carboplatin (CBDCA), Vindesine (VDS) and Radiotherapy in Stage III Non Small Cell Lung Cancer (NSCLC)
Authors: Tomirotti Maurizio , Gramegna Giovanni , Mantellini Paolo , Fossati Vittorio , Mezzetti Maurizio , Dimaiuta Mariastella , Scanni Alberto 
Published: April 2018

Aims Aim of the study was to test, in a cooperative and prospective trial, the effectiveness and feasibility of a chemo-radio-therapy program in stage III non small cell lung cancer (NSCLC). Methods The schedule consisted in carboplatin (CBDCA) 150 mg/m2/iv on days 1, 3, 5 and vindesine VDS 2.5 mg/m2/iv on days 1, 8, 15, 22 every 4 weeks for 2 cycles followed by radiotherapy 60 Gy with CBDCA 50 mg/m2 weekly as radioenhancer. The same schedule was proposed as neoadjuvant treatment in 10/47 patients (stage III A) and as exclusive treatment in 37/47 (stage III B) admitted patients. Results In the neoadjuvant subgroup partial remission was obtained in 5/10 patients, and 3 of them underwent surgery with consequent CR. In the stage III B subgroup, 2 complete remissions were obtained (survival 14 and 9+ months). Toxicity was mild. Conclusions Our results confirm the feasibility of the schedule in stage III NSCLC.