bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioengineering Organs for Blood Detoxification
Authors: Legallais Cécile , Kim Dooli , Mihaila Sylvia M. , Mihajlovic Milos , Figliuzzi Marina , Bonandrini Barbara , Salerno Simona , Yousef Yengej Fjodor A. , Rookmaaker Maarten B. , Sanchez Romero Natalia , Sainz‐Arnal Pilar , Pereira Ulysse , Pasqua Mattia , Gerritsen Karin G. F. , Verhaar Marianne C. , Remuzzi Andrea , Baptista Pedro M. , De Bartolo Loredana , Masereeuw Rosalinde , Stamatialis Dimitrios 
Published: September 2018

AbstractFor patients with severe kidney or liver failure the best solution is currently organ transplantation. However, not all patients are eligible for transplantation and due to limited organ availability, most patients are currently treated with therapies using artificial kidney and artificial liver devices. These therapies, despite their relative success in preserving the patients' life, have important limitations since they can only replace part of the natural kidney or liver functions. As blood detoxification (and other functions) in these highly perfused organs is achieved by specialized cells, it seems relevant to review the approaches leading to bioengineered organs fulfilling most of the native organ functions. There, the culture of cells of specific phenotypes on adapted scaffolds that can be perfused takes place. In this review paper, first the functions of kidney and liver organs are briefly described. Then artificial kidney/liver devices, bioartificial kidney devices, and bioartificial liver devices are focused on, as well as biohybrid constructs obtained by decellularization and recellularization of animal organs. For all organs, a thorough overview of the literature is given and the perspectives for their application in the clinic are discussed.
Thin‐Film Composite Polyionic Liquid Gel Membranes and Their Potential for Nanofiltration in Organic Solvents
Authors: Al‐kharabsheh Salem , Bernstein Roy 
Published: September 2018

AbstractPolymeric ionic liquid (PIL) gels can serve as a promising material for the fabrication of solvent resistance nanofiltration (SRNF) membranes, given the solubility and the high delocalization of the counterion of PILs in organic solvents. This research describes the fabrication of a new thin‐film composite membrane (TFC) with a crosslinked PIL (i.e., PIL gel) as an active layer and demonstrates its great potential as an SRNF membrane. A hydrophobic and positively charged thin‐film PIL gel (100–400 nm) is successfully grafted onto a polyethersulfone membrane. The grafting degree, surface charge, and cross‐linker density depend on the grafting conditions. This, it turn, governs the permeability and selectivity of the membranes tested in acetonitrile and ethanol solutions, good and poor solvents for the grafted PIL gel, respectively. These changes are attributed to the trade‐off between the membrane surface properties in the two solvents. In particular, the membrane that has a high grafting degree, surface charge, and cross‐linker density yields high permeance and rejection in acetonitrile. Furthermore, the membrane performance is stable in ethanol for one week. Due to the wide variety of PIL monomers, TFC membranes with different properties can be developed based on the solvent properties.
Dual Sensing Arrays for Surface Plasmon Resonance (SPR) and Surface‐Enhanced Raman Scattering (SERS) Based on Nanowire/Nanorod Hybrid Nanostructures
Authors: Lee Kuang‐Li , Hung Chia‐Yu , Pan Ming‐Yang , Wu Tsung‐Yeh , Yang Sen‐Yeu , Wei Pei‐Kuen 
Published: September 2018

AbstractA multifunctional sensing array with gold nanowire–nanorod hybrid nanostructures for dual detection of surface plasmon resonance (SPR) and surface‐enhanced Raman scattering (SERS) is presented. The cost‐effective and arrayed nanostructures are made simply onto plastic films using hot‐embossing nanoimprint lithography. Five different hybrid nanostructures are studied and compared by measuring SERS enhancement factor and SPR thickness sensitivity. The combination of nanowire and nanorod structures in specific arrangement and quantities of nanorods can not only enhance the SERS effect but also further increase the SPR thickness sensitivity. The area percentage of nanorods of 16.51% can achieve the highest SPR thickness sensitivity and 106 SERS enhancement. On comparison of the nanowire structure, the SERS signal and SPR thickness sensitivity of nanowire/nanorod hybrid nanostructure are increased up to 6 times and 2 times simultaneously. The estimated SERS enhancement factor and SPR thickness sensitivity are 2.82 × 106 and 0.74 (nm/nm), respectively. The enhanced sensitivity is attributed to the increased nanorods contributing to dense hot spots and the reduced SPR evanescent length caused by the localized surface plasmons. These results are verified by finite‐difference time‐domain (FDTD) calculations. Such low‐cost SPR–SERS chips for multifunctional chemical analysis can increase the reliability of biological detection and broaden sensing applications.
Graphene‐Based Electronic Immunosensor with Femtomolar Detection Limit in Whole Serum
Authors: Andoy Nesha M. , Filipiak Marcin S. , Vetter Daniel , Gutiérrez‐Sanz Óscar , Tarasov Alexey 
Published: September 2018

AbstractPurely electronic diagnostic devices that are sensitive to biomolecules' intrinsic charge present a very attractive platform for point‐of‐care (PoC) applications, since they can operate under label‐free conditions. In this report, a graphene‐based electrolyte‐gated field‐effect transistor is developed as an immunosensor capable of sensitive analyte detection, even in the complex environment of physiological samples. The coimmobilization of an antibody fragment (F(ab′)2) and polyethylene glycol on the graphene surface allows for a highly sensitive and selective detection of a protein analyte, with a limit of detection in the low femtomolar range, both in high ionic strength buffer and undiluted serum. Multiparametric analysis of the device's analyte‐dependent electronic response shows that the mechanism behind this very sensitive detection cannot be explained by a commonly reported electrostatic gating effect. Rather, the observed combination of charge neutrality point shifts and asymmetric mobility changes are attributed to the modulation of scattering by charged impurities, which seem to dominate the device's transfer characteristics. Furthermore, the reproducibility of the normalized signal response obtained from several different devices shows that this graphene‐based immunosensor is capable of direct and quantitative measurements of protein analytes in untreated serum, imperative for diagnostic tools geared toward PoC applications.
n‐Type Doping Effect of CVD‐Grown Multilayer MoSe2 Thin Film Transistors by Two‐Step Functionalization
Authors: Hong Seongin , Im Haelin , Hong Young Ki , Liu Na , Kim Sunkook , Park Jun Hong 
Published: September 2018

AbstractMolybdenum diselenide (MoSe2) has attracted attention as a potential semiconductor platform. However, the as‐synthesized MoSe2 field‐effect transistors (FETs) tend to exhibit the arbitrary properties of n‐type, p‐type, or ambipolar behavior due to the uncontrolled growth condition. Here, two‐step functionalization is proposed to achieve n‐doping effect and long‐term stability in chemical vapor deposition (CVD)–grown MoSe2 FETs using oxygen plasma treatment followed by the deposition of an Al2O3 layer. After the two‐step surface functionalization procedure, three types of multilayer MoSe2 FETs are all converted to n‐type with the improvement of their electrical characteristics and stability; the n‐doped multilayer MoSe2 FETs exhibit an enhancement in field‐effect mobility from 12.23 to 31.57 cm2 V−1 s−1 and a 3 times higher Ion/Ioff, compared to pristine multilayer MoSe2 FETs. This enhancement of electric performance is attributed to the oxidation of topmost MoSe2 to interfacial MoOx with SeOx induced by the oxygen plasma treatment, as well as to the existence of fixed positive charges in deposited Al2O3. The functionalized devices exhibit excellent stability against stress, as confirmed with negative bias illumination stress tests for 7200 s. Moreover, an environmental stability test for 21 days reveals no degradation in electric performance of MoSe2 FETs.
Temperature Dependent n‐Type Self Doping in Nominally 19‐Electron Half‐Heusler Thermoelectric Materials
Authors: Anand Shashwat , Xia Kaiyang , Zhu Tiejun , Wolverton Chris , Snyder Gerald Jeffrey 
Published: September 2018

AbstractThe discovery of a semiconducting ground state XyYZ (y = 0.8 or 0.75) in nominally 19‐electron half‐Heusler materials warrants a closer look at their apparently metallic properties that often make them good thermoelectric (TE) materials. By systematically investigating the temperature dependence of off‐stoichiometry (x) in V0.8+xCoSb, Nb0.8+xCoSb, and Ti0.75+xNiSb it is found that x invariably increases with increasing temperature, leading to an n‐type self‐doping behavior. In addition, there is also a large phase width (range of x) associated with each phase that is temperature dependent. Thus, unlike in typical 18‐electron half‐Heuslers (e,g, TiNiSn), the temperature dependence of vacancy and carrier concentration (n) in nominally 19‐electron half‐Heuslers links its transport properties to synthesis conditions. The temperature dependence of x and n are understood using density functional theory based defect energies (Ed) and phase diagrams. Ed are calculated for 21 systems which can be used in predicting solubility in this family of compounds. Using this simple strategy, suitable composition and temperature synthesis conditions are devised for obtaining an optimized n to engineer TE properties in phase‐pure V0.8+xCoSb, and the previously unexplored Ta0.8+xCoSb.
Inorganic Materials as Hole Selective Contacts and Intermediate Tunnel Junction Layer for Monolithic Perovskite‐CIGSe Tandem Solar Cells
Authors: Wang Yajie , Wenisch Robert , Schlatmann Rutger , Lauermann Iver 
Published: September 2018

AbstractIn order to surpass the theoretical limitation defined by the Shockley–Queisser equation for photovoltaic solar cells, multijunction devices are needed. Monolithic perovskite‐Cu(In, Ga)(Se, S)2(CIGSe) tandem solar cells have recently become a hot research topic in photovoltaics because of the emergence of perovskite solar cells with high power conversion efficiency and the development of thin film chalcopyrite CIGSe solar cells with tunable bandgap and low cost manufacturing processes. In this review, some p‐type wide bandgap semiconductors are investigated as intermediate inorganic hole transport materials (IIHTM) and components of a tunnel junction in monolithic perovskite‐CIGSe tandem solar cells, which meet the requirements of band alignment and low‐temperature deposition process. The authors focus on designing a tandem configuration including band alignment, current matching, and optical management, describing some potential candidates of IIHTM owing to their successful implementation in single junction perovskite solar cells and the possibility of application in intermediate layers for tandem devices. Recent progress in the development of inorganic hole conductors is highlighted, and also some of the authors' work on IIHTM and their applications are presented. Finally, future research directions for IIHTM layers and monolithic perovskite‐CIGSe tandem solar cells are presented, with an aim to achieve higher photovoltaic performance than current devices.
Scalable Solid‐State Synthesis of Highly Dispersed Uncapped Metal (Rh, Ru, Ir) Nanoparticles for Efficient Hydrogen Evolution
Authors: Wang Qi , Ming Mei , Niu Shuai , Zhang Yun , Fan Guangyin , Hu Jin‐Song 
Published: September 2018

AbstractGreen and scalable syntheses of highly dispersed supported metal nanocatalysts (SMNCs) are of significant importance for heterogeneous catalysis in industry. In order to achieve nanosized SMNCs and prevent metal nanoparticles (NPs) from aggregation, the traditional liquid syntheses commonly require organic capping agents and low metal loading, which are unfavorable for practical production of SMNCs. Herein, a green and facile solid‐state approach is reported for a general synthesis of Rh, Ru, and Ir NPs highly dispersed on different carbon supports via a room‐temperature mortar grinding. The synthesis is easy to scale up and no organic solvent is needed. Metal NPs are free of capping agents and in a couple of nanometers with a uniform size distribution. Benefiting from the above features and high intrinsic activity, Rh NP/C shows the superior activity for hydrogen evolution reaction (HER) in terms of an ultralow overpotential of 7 mV at 10 mA cm−2, outperforming the state‐of‐the‐art HER electrocatalysts. The cell voltage to output a stable current density of 10 mA cm−2 is only 1.53 V for the electrolyzer with Rh NP/C cathode. These results indicate that the present scalable solid‐state synthetic strategy paves a new avenue for mass production of highly efficient SMNCs for diverse applications.
Tobacco product use among workers in the construction industry, United States, 2014‐2016
Authors: Syamlal Girija , King Brian A. , Mazurek Jacek M. 
Published: September 2018

BackgroundAlthough cigarette smoking has declined among U.S. workers, smoking remains high among construction workers. This study assessed tobacco product use among U.S. construction workers.MethodsThe 2014‐2016 National Health Interview Survey data for U.S. working adults were analyzed.ResultsOf the 10.2 (6.3% of working adults) million construction workers, 35.1% used any tobacco product; 24.4% were cigarette smokers, 8.3% were cigar, cigarillo, pipe or hookah smokers, 7.8% were smokeless tobacco users, 4.4% were e‐cigarette users, and 7.6% used ≥2 tobacco product users. Tobacco use varied by worker characteristics, with highest tobacco use (>35%) among those reporting ≤5 years on the job, temporary work status, job insecurity, or an unsafe workplace. Construction workers had higher odds of tobacco product use than non‐construction workers.ConclusionsOver one‐third of U.S. construction workers use tobacco products and disparities exist across sub‐groups. Workplace tobacco control strategies could reduce tobacco use among this population.
Copper‐Mediated Synthesis of (Diethylphosphono)difluoromethyl Thioethers from Diazonium Salts, NaSCN, and TMS‐CF2PO(OEt)2
Authors: Ou Yang , Gooßen Lukas J. 
Published: September 2018

AbstractAn expedient one‐pot synthesis of (diethylphosphono) difluoromethyl thioethers is described consisting of a Sandmeyer thiocyanation with in situ‐fluoroalkylation using TMS‐CF2PO(OEt)2 as the fluorine source. Both steps are mediated by copper(I) thiocyanate. The reaction is applicable to a wide range of functional groups, as demonstrated by 22 examples.
Disability poverty and ageing in regional Australia: The impact of disability income reforms for indigenous Australians
Authors: Soldatic Karen 
Published: September 2018

AbstractAustralian disability policy has undergone considerable reform since the early 2000s. While recent research and scholarship has largely focused on the new National Disability Insurance Scheme, there is a dearth of research that examines the impact of reform to the Disability Support Pension, and even less so the effects on Indigenous Australians living with disability. This is surprising as a higher proportion of Indigenous Australians live with disability than the non‐Indigenous population. This article pays particular attention to the experiences of Aboriginal Australians who have acquired a disability after extensive years of working (25–40 years), yet are still of workforce age (less than 65 years of age). Because of tightened eligibility criteria for the Disability Support Pension, people in this group are placed onto the lower paid Newstart Allowance (general unemployment benefit). The article illustrates the high levels of poverty that Aboriginal Australians with disabilities experience daily, and the ongoing costs they incur in managing Newstart conditionality to maintain continued access to the general unemployment benefit.
Carving Out Pores in Redox‐Active One‐Dimensional Coordination Polymers
Authors: Clayman Naomi E. , Manumpil Mary Anne , Umeyama Daiki , Rudenko Andrey E. , Karunadasa Hemamala I. , Waymouth Robert M. 
Published: September 2018

AbstractReduction of the insulating one‐dimensional coordination polymer [Cu(abpy)PF6]n, 1 a(PF6), (abpy=2,2′‐azobispyridine) yields the conductive, porous polymer [Cu(abpy)]n, 2 a. Pressed pellets of neutral 2 a exhibit a conductivity of 0.093 S cm−1 at room temperature and a Brunauer–Emmett–Teller (BET) surface area of 56 m2 g−1. Fine powders of 2 a have a BET surface area of 90 m2 g−1. Cyclic voltammetry shows that the reduction of 1 a(PF6) to 2 a is quasi‐reversible, indicative of facile charge transfer through the bulk material. The BET surface area of the reduced polymer 2 can be controlled by changing the size of the counteranion X in the cationic [Cu(abpy)X]n. Reduction of [Cu(abpy)X]n with X=Br (2 b) or BArF (2 c; BArF=tetrakis(3,5‐bis(trifluoromethyl)phenyl)), affords [Cu(abpy)]n polymers with surface areas of 60 and 200 m2 g−1, respectively.
Enabling Fluorinated MOF‐Based Membranes for Simultaneous Removal of H2S and CO2 from Natural Gas
Authors: Liu Gongping , Cadiau Amandine , Liu Yang , Adil Karim , Chernikova Valeriya , Carja Ionela‐Daniela , Belmabkhout Youssef , Karunakaran Madhavan , Shekhah Osama , Zhang Chen , Itta Arun K. , Yi Shouliang , Eddaoudi Mohamed , Koros William J. 
Published: September 2018

AbstractMembrane‐based gas separations are energy efficient processes; however, major challenges remain to develop high‐performance membranes enabling the replacement of conventional separation processes. Herein, a new fluorinated MOF‐based mixed‐matrix membrane is reported, which is formed by incorporating the MOF crystals into selected polymers via a facile mixed‐matrix approach. By finely controlling the molecular transport in the channels through the MOF apertures tuned by metal pillars and at the MOF‐polymer interfaces, the resulting fluorinated MOF‐based membranes exhibit excellent molecular sieving properties. These materials significantly outperform state‐of‐the‐art membranes for simultaneous removal of H2S and CO2 from natural gas—a challenging and economically important application. The robust fluorinated MOFs (NbOFFIVE‐1‐Ni, AlFFIVE‐1‐Ni), pave a way to efficient membrane separation processes that require precise discrimination of closely sized molecules.
Chemoproteomic Profiling of Phosphoaspartate Modifications in Prokaryotes
Authors: Chang Jae Won , Montgomery Jeffrey E. , Lee Gihoon , Moellering Raymond E. 
Published: September 2018

AbstractPhosphorylation at aspartic acid residues represents an abundant and critical post‐translational modification (PTM) in prokaryotes. In contrast to most characterized PTMs, such as phosphorylation at serine or threonine, the phosphoaspartate moiety is intrinsically labile, and therefore incompatible with common proteomic profiling methods. Herein, we report a nucleophilic, desthiobiotin‐containing hydroxylamine (DBHA) chemical probe that covalently labels modified aspartic acid residues in native proteomes. DBHA treatment coupled with LC‐MS/MS analysis enabled detection of known phosphoaspartate modifications, as well as novel aspartic acid sites in the E. coli proteome. Coupled with isotopic labelling, DBHA‐dependent proteomic profiling also permitted global quantification of changes in endogenous protein modification status, as demonstrated with the detection of increased E. coli OmpR phosphorylation, but not abundance, in response to changes in osmolarity.
Transcript Profiling of MRSA Biofilms Treated with a Halogenated Phenazine Eradicating Agent: A Platform for Defining Cellular Targets and Pathways Critical to Biofilm Survival
Authors: Abouelhassan Yasmeen , Zhang Yanping , Jin Shouguang , Huigens Robert W. 
Published: September 2018

AbstractBacterial biofilms are surface‐attached communities of non‐replicating bacteria innately tolerant to antibiotics. Biofilms display differential gene expression profiles and physiologies as compared to their planktonic counterparts; however, their biology remains largely unknown. In this study, we used a halogenated phenazine (HP) biofilm eradicator in transcript profiling experiments (RNA‐seq) to define cellular targets and pathways critical to biofilm viability. WoPPER analysis with time–course validation (RT‐qPCR) revealed that HP‐14 induces rapid iron starvation in MRSA biofilms, as evident by the activation of iron‐acquisition gene clusters in 1 hour. Serine proteases and oligopeptide transporters were also found to be up‐regulated, whereas glycolysis, arginine deiminase, and urease gene clusters were down‐regulated. KEGG analysis revealed that HP‐14 impacts metabolic and ABC transporter functional pathways. These findings suggest that MRSA biofilm viability relies on iron homeostasis.
Electrophilic Phosphonium Cation‐Mediated Phosphane Oxide Reduction Using Oxalyl Chloride and Hydrogen
Authors: Stepen Arne J. , Bursch Markus , Grimme Stefan , Stephan Douglas W. , Paradies Jan 
Published: September 2018

AbstractThe metal‐free reduction of phosphane oxides with molecular hydrogen (H2) using oxalyl chloride as activating agent was achieved. Quantum‐mechanical investigations support the heterolytic splitting of H2 by the in situ formed electrophilic phosphonium cation (EPC) and phosphane oxide and subsequent barrierless conversion to the phosphane and HCl. The reaction can also be catalyzed by the frustrated Lewis pair (FLP) consisting of B(2,6‐F2C6H3)3 and 2,6‐lutidine or phosphane oxide as Lewis base. This novel reduction was demonstrated for triaryl and diaryl phosphane oxides providing access to phosphanes in good to excellent yields (51–93 %).
Heterogenized Cu (II) salen complex grafted on graphene oxide nanosheets as a precursing catalyst for the Pd‐free Sonogashira coupling
Authors: Ghabdian Mahdieh , Nasseri Mohammad A. , Allahresani Ali , Motavallizadehkakhky Alireza 
Published: September 2018

Cu (II) salen complex immobilized on graphene oxide nanosheets [Cu (II) salen@GO] was synthesized with 3‐chloropropyltrimethoxysilan as a linker and wholly characterized using various techniques like X‐ray diffraction, Fourier‐transform infrared, scanning electron microscopy/energy‐dispersive X‐ray spectroscopy, transmission electron microscopy, as well as atomic absorption spectroscopy (AAS). Cu (II) salen@GO as an effective heterogeneous catalyst has been investigated for the Sonogashira coupling reaction in dimethylsulfoxide with good to high yield (98%) in 4 hr at 110°C when the loading of Cu was 0.7 mmol g−1 based on Cu element analysis by AAS. It was understood that heterogeneous catalyst was as active as its homogeneous analog, and presented good recoverability and no significant loss in activity within successive runs.
Synthesis of molecularly imprinted polymer by suspension polymerization for selective extraction of p‐hydroxybenzoic acid from water
Authors: Liu Xiaojuan , Wu Fengjing , Au Chaktong , Tao Qi , Pi Mingyu , Zhang Wenhui 
Published: September 2018

ABSTRACTMolecularly imprinted polymer (MIP) for selective extraction of p‐hydroxybenzoic acid (p‐HB) was synthesized by suspension polymerization using p‐HB as template, 4‐vinyl pyridine as functional monomer and ethylene glycol dimethacrylate as crosslinker. As characterized by scanning electron microscopy, the MIP particles are spherical, with size ranging from 1 to 8 μm. Compared with the non‐imprinted polymer (NIP), the MIP shows higher binding capacity toward p‐HB: maximum binding capacity for p‐HB being 8.07 μmol g−1 over MIP and 3.88 μmol g−1 over NIP. The adsorption of p‐HB on MIP follows the Freundlich model and displays pseudo‐second‐order kinetics. The results of selective and competitive binding experiments confirm that the molecularly imprinted sites have excellent recognition ability toward p‐HB. The results reveal that the MIP is a promising adsorbent for selective extraction of p‐HB from water samples. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46984.