bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neck Pain & Disability among School Teachers and its
Association with Gender, Body Mass Index, Classes per Week and Method of Lecture
Delivery
Authors: Arsh Aatik , Idrees Sohail , Zafar Naveed , Amin Brekhna , Ahad Shah 
Published: September 2019

Abstract
Purpose Neck pain is common among school teachers due to regular
involvement in teaching activities. The purpose of this study was to determine
the neck Pain & disability among school teachers and its association
with gender, body mass index, classes per week and method of lecture
delivery.
Methods A cross sectional study was conducted in Peshawar Pakistan from
August 2017 to February 2018. A self administered questionnaire was used to
collect demographic and teaching related information while Neck Disability Index
(NDI) was used to assess neck disability. School teachers having at least 1 year
teaching experience were included in the study. Teachers involved in
administrative activities and/or having any systemic disease or
co-morbidity were excluded. SPSS version 20 was used to analyze the data.
Results Mean age of the participants was 31.99±6.93. There were
110 (39.6%) male and 168 (60.4%) female participants. Out of
total participants, 99(35.6%) teachers reported that they had neck pain.
Majority (n=188, 67.6%) of participants had no neck pain related
disability while 63 (22.7%) had mild, 22 (7.9%) had moderate and
5 (1.8%) had severe disability. None of the participants had complete
disability. Female gender was significantly associated (P-value<0.05)
with neck pain and disability.
Conclusion Prevalence of neck pain is high among school teachers. Female
teachers and those who take more than 10 classes per week are more prone to
developing neck pain.
Rhein Augments Antiproliferative Effects of Atezolizumab Based on Breast Cancer (4T1) Regression
Authors: Shen Zhanyun , Zhu Bo , Li Jiao , Qin Luping 
Published: September 2019

AbstractRhein, an anthraquinone extracted from rhubarb, is used in traditional Chinese medicine for diuresis, diarrhoea, inflammation, and immune regulation. Atezolizumab, a programmed cell death ligand 1 monoclonal antibody, is mainly used to treat bladder cancer and non-small cell lung cancer unresponsive to chemotherapy. We explored the effects of rhein and atezolizumab in combination on breast cancer. Mice with established 4T1 breast cancer xenografts were administered rhein (10 mg/kg) and atezolizumab (10 mg/kg), alone and in combination, and the effects on tumour growth were evaluated. The proportion of CD8+ T cells in the spleen and tumour tissue, the levels of TNF-α, and interleukin-6 in serum as well as the mRNA levels of apoptotic factors (caspase-3, caspase-8, caspase-9, and Bax/Bcl-2) were also evaluated. All of the treatment groups had inhibitory effects on the xenograft tumour growth, with results that were significantly different from those in the control group. In addition, the proportion of CD8+ T cells in the spleen and tumour was significantly increased in the combination therapy group and was significantly different from the other treatment groups. The serum levels of TNF-α and IL-6 were significantly increased in the rhein and combination therapy groups. Finally, the levels of various apoptotic factors in tumour tissues were significantly higher in the combination treatment group than those in the other groups. Administration of rhein, atezolizumab, or their combination all had therapeutic effects on 4T1 breast cancer xenografts in mice, with the combination treatment having stronger effects.
Pharmacogenetics of Atremorine-Induced Neuroprotection and Dopamine Response in Parkinsonʼs Disease
Authors: Cacabelos Ramón , Carrera Iván , Alejo Ramón , Fernández-Novoa Lucía , Cacabelos Pablo , Corzo Lola , Rodríguez Susana , Alcaraz Margarita , Tellado Iván , Cacabelos Natalia , Pego Rocío , Carril Juan C. 
Published: September 2019

AbstractAtremorine is a novel bioproduct with neuroprotective effects on dopaminergic neurons and a natural L-DOPA donor in Parkinsonʼs disease (PD). In the present study, we show the effects of a single dose of Atremorine (5 g, p. o.) on plasma dopamine (DA) response and brain function in PD (n = 183) and the influence that pathogenic (LRRK2), metabolic (CYP2D5, CYP2C9, CYP2C19, CYP3A5, NAT2), transporter (ABCB1), pleiotropic (APOE), and detoxifying genes (CYP1B1, GSTT1, GSTP1, GSTM1, SOD2) involved in the pharmacogenetic network exerts on Atremorine-induced DA response. Over 90% of PD patients at diagnosis show plasma DA levels below 20 pg/mL. Atremorine induces DA synthesis causing a significant increase in plasma DA levels 1 h after administration in practically 100% of patients. Females tend to show lower basal DA levels than males and the response of DA to Atremorine is stronger in males than in females. Atremorine-induced DA response is pharmacogenotype-specific and lasts from 6 – 12 h depending upon the pharmacogenetic profile of each patient. Genetic variants in pathogenic genes, metabolic genes, and genes involved in the detoxification processes affect the response of DA to Atremorine in a genotype-specific manner. Atremorine or any of its bioactive components can cross the blood-brain barrier and improve brain function and motor function, as revealed by the reduction in slow wave activity in brain mapping and psychometric assessment, respectively. Atremorine is a selective neuroprotective agent for dopaminergic neurons with prophylactic and therapeutic potential in PD.
Prevalence of Styloid Process Elongation on Panoramic Radiography in the Turkey Population from Cappadocia Region
Authors: Gokce Cumali , Sisman Yildiray , Ertas Elif Tarim , Akgunlu Faruk , Ozturk Ahmet 
Published: September 2019

ABSTRACTObjectives: The aim of this study is to determine the prevalence of styloid process elongation (SPE) detected on panoramic radiographs (PRs) in Cappadocia region population in Turkey and to investigate the SPE incidences in relation to the age subgroups.Methods: Between 2004 to 2007 years, a random sample of 750 PRs was collected from the data files and any questionable PR was excluded. Therefore, 698 PRs were included in the present study. The subjects were divided into six age subgroups: 10–19, 20–29, 30–39, 40–49, 50–59 and 60 years and older. Fifty-four (7.7%) patients demonstrated SPE at least one side.Results: There were statistical differences between 10-19, 20-29 age subgroups and 30-39, 5059 age subgroups in terms of the SPE prevalence, but not other subgroups.
Conclusions: According to our knowledge, this is the highest prevalence in comparison to the other Turkish reports and the first study in terms of the SPE prevalence in Cappadocia region population. Also, the subgroup analyse suggested that the age may not have a role in the elongation of the SP. (Eur J Dent 2008;2:18-22)
Microleakage of Class-V Composite Restorations with Different Bonding Systems on Fluorosed Teeth
Authors: Küçükeşmen Çiḡdem , Sönmez Hayriye 
Published: September 2019

ABSTRACTObjectives: To examine the effects of dental fluorosis and total and self-etch bonding systems on microleakage of Class-V composite restorations in permanent molar teeth.Methods: Teeth were classified as three main groups according to Thylstrup-Fejerskov Index (TFI) as TFI=0, TFI=1-3 and TFI=4. Total and self-etching/bonding procedures were determined for each main group. Total-etching procedures were acid-etching for 30s and acid-etching for 60s with Single Bond/total-etch bonding system. Self-etching procedure was applied with Prompt-L-Pop/self-etch bonding system. 63 box-shaped Class-V cavities (4×2×2 mm) were prepared on mid-buccal/palatinal/lingual surfaces of teeth for totalling nine test groups (n=7). Restorations with composite material (Charisma) polymerized with halogen unit for 40s. Teeth were thermocycled between +5°C - +55°C (×500), immersed in 0.5% basic-fuchsin solution (37°C, 24h) and separated longitudinally in bucco-lingual direction. Dye penetration was examined under stereomicroscope (3.2×10).Results: Microleakage levels were higher in teeth of TFI=4 than TFI=0 occlusally or cervically (P<.05). In TFI=0; total-etched teeth for 30s have statistically shown more leakage than total-etched teeth for 60s occlusally or cervically (P<.05). In TFI=4; microleakage levels were significantly higher for 30s than 60s cervically (P<.05). For all TFI levels, microleakage was commonly increased with self-etch system than total-etch system (P<.05). Generally, higher leakage was present at cervical margins than occlusal margins (P<.05).Conclusions: Microleakage has increased by severity of dental fluorosis. Generally, more leakage was observed in total-etched teeth for 30s than 60s. Microleakage was commonly higher in self-etched teeth than total-etched teeth. More leakage was present at cervical margins than occlusal margins. (Eur J Dent 2008;2:48-58)
Unusual Cases of the Transmigrated Mandibular Canines: Report of 4 Cases
Authors: Aktan Ali Murat , Kara Sami , Akgunlu Faruk , sman Eren , Malkoc Siddik 
Published: September 2019

ABSTRACTThe canine impaction is not uncommon in dental literature, but the transmigration of mandibular canine is a rare phenomenon, and some of them are far more extreme than others. In this study, we aimed to present the more extreme cases of the four transmigrated mandibular canine cases with special emphasis on their classification. (Eur J Dent 2008;2:122-126)
Apical Extrusion of Intracanal Debris Using Two Engine Driven and Step-Back Instrumentation
Techniques: An In-Vitro Study
Authors: Kustarci Alper , Akdemir Neslihan , Siso Seyda Herguner , Altunbas Demet 
Published: September 2019

ABSTRACTObjectives: The purpose of this study was to compare in-vitro the amount of debris extruded apically from extracted teeth, using K3, Protaper rotary instruments and manual step-back technique.Methods: Forty five human single-rooted mandibular premolar teeth were randomly divided into 3 groups. The teeth in 3 groups were instrumented until reaching the working length with K3, Protaper rotary instruments and K-type stainless steel instruments with manual step-back technique, respectively. Debris extruded from the apical foramen was collected into centrifuge tubes and the amount was determined. The data obtained were analyzed using Kruskal-Wallis one-way analysis of variance and Mann-Whitney U tests, with P=.05 as the level for statistical significance.Results: Statistically significant difference was observed between K3, Protaper and step-back groups in terms of debris extrusion (P<.05). Step-back group had the highest mean debris weight, which was significantly different from the K3 and Protaper groups (P<.05). The lowest mean debris weight was related to K3 group, which was significantly different from the Protaper group (P<.05).Conclusions: Based on the results, all instrumentation techniques produced debris extrusion. The engine-driven Ni-Ti systems extruded significantly less apical debris than step-back technique. However, Protaper rotary instruments extruded significantly more debris than K3 rotary instruments. (Eur J Dent 2008;2:233-239)
Lactoferrin in Gingival Crevicular Fluid and Peripheral Blood during Experimental Gingivitis
Authors: Ozdemir Burcu , Ozcan Gonen , Karaduman Burcu , Teoman Aslı Idil , Ayhan Eylem , Ozer Nazmi , Us Durdal 
Published: September 2019

ABSTRACTObjectives: Lactoferrin (LF) is an iron binding protein and stored in the specific granules of granulocytes. It is released by degranulation following granulocyte activation. A positive correlation was previously reported between periodontitis and LF titers of gingival crevicular fluid (GCF) and blood. The purpose of this study was to examine alterations of GCF and blood levels of LF (LF-GCF and LF-BL, respectively), employing the experimental gingivitis model.Methods: Twelve systemically healthy volunteers, aged 19-21, were selected. Pre-experimental phase of hygiene was followed by a 14-day experimental gingivitis phase in which subjects refrained from all oral hygiene procedures. After that subjects resumed optimal plaque control for 21 days of recovery period. At days 0 (baseline), 14 and 35 gingival crevicular fluid (GCF) and blood samples were collected and plaque index (PI), gingival index (GI), bleeding on probing (BOP) and probing pocket depth scores were recorded. LF levels were measured with commercial enzyme-linked immunosorbent assay (ELISA) kit.Results: PI, GI, BOP and LF-GCF increased significantly after 14 days of experimental gingivitis period and decreased significantly after reinstitution of oral hygiene measures (P<.05). LF-BL appeared to follow the same pattern. Significant negative correlation was detected between the level of LF-BL and BOP at day 14 (P<.05), whereas significant positive correlation was noticed between LFBL and clinical scores PI, GI and BOP at day 35 (P<.05).Conclusions: LF-BL followed the same pattern with LF-GCF and clinical scores during the experimental gingivitis and recovery periods, although alterations of the LF-BL appeared statistically insignificant. (Eur J Dent 2009;3:16-23)
Survival and Success of ITI Implants and Prostheses: Retrospective Study of Cases with 5-Year Follow-Up
Authors: Gokcen-Rohlig Bilge , Yaltirik Mehmet , Ozer Senem , Tuncer Ebru Demet , Evlioglu Gulumser 
Published: September 2019

ABSTRACTObjectives: The use of osseointegrated implants as an endoestal anchorage device to provide support for dental prostheses is a reliable and widely accepted treatment modality. The purpose of this study was to evaluate the clinical performance of non-submerged implants placed in the maxilla or in the mandible.Methods: A total of 146 International Team for Implantology (ITI) (Straumann AG, Waldenburg, Switzerland) implants were placed in 42 patients (20 women, 22 men, mean age 42). The cases were examined retrospectively in order to evaluate the clinical efficiency of non-submerged ITI implants and to determine the success rate of implant retained/supported prosthesis after a 5-year period. All implants were assessed clinically and radiographically on a yearly basis.Results: The 5-year cumulative success rates for maxillary and mandibular implants were 91.00% and 97.81%, respectively. The most common prosthetic complication was abutment accompanied by screw loosing (3.42%). Veneering material fracture was documented in only one patient.Conclusions: Within the limitations of the observation period and sample number, the present findings confirmed sufficient success and survival rates of ITI implants placed in mandible as well as implants placed in the maxilla after a 5-year period. (Eur J Dent 2009;3:42-49)
Influence of Different Drinks on the Colour Stability of Dental Resin Composites
Authors: Topcu Fulya Toksoy , Sahinkesen Gunes , Yamanel Kivanc , Erdemir Ugur , Oktay Elif Aybala , Ersahan Seyda 
Published: September 2019

ABSTRACTObjectives: The objective of this study was to evaluate the discolouration effects of artificial saliva, granule lemon juice, coffee (without sugar), coca cola, sour cherry juice, fresh carrot juice and red wine on resin-based composite materials that are commonly used in restorative dentistry.Methods: Colour of four brands of resin composites (Filtek Z 250 (3M Espe), Filtek Supreme (3M Espe), Quadrant (Cavex), Charisma (Heraeus-Kulzer)) of A2 shade was measured after one day of immersion in eight different solutions. Colour measurements were obtained by using a XL-20 Trismus Colourimeter and colour differences (�E) were estimated. For statistical evaluation, analysis of variance (ANOVA), Dunnett and Tukey tests were used at a significance level of 0.05.Results: For the four restorative materials tested, the lowest ΔE values were observed in the artificial saliva, while ΔE values were the highest in red wine group. When comparing the four different restorative materials, Filtek Supreme exhibited the least colour changes whereas Filtek Z250 was the least colour-stable.Conclusions: Dental resin composites and drinking solutions were significant factors that may affect the colour stability. After immersion for one day, all materials showed visible colour changes. The red wine solution exhibited more staining than others in three groups. Filtek Supreme showed significantly the least colour change due to its nano particle sizes. (Eur J Dent 2009;3:50-56)
Effects of Current Provisional Restoration Materials on the Viability of Fibroblasts
Authors: Ulker Mustafa , Ulker H. Esra , Zortuk Mustafa , Bulbul Mehmet , Tuncdemir Ali Riza , Bilgin M. Selim 
Published: September 2019

ABSTRACTObjectives: The aim of the present study was to evaluate the cytotoxic effects of three different provisional restoration materials on fibroblasts. Two bis-acrylic based [Tempofit Duomix (Detax), Protemp 3 Garant (3M ESPE)] and one urethan dimethacrylate [Revotek LC (GC Corporation)] based provisional restoration materials used.Methods: Materials were prepared according to the manufacturers’ instructions in standard teflon disks (2×5mm) and four samples were extracted in 7 ml of Basal Medium Eagle with 10% new born calf serum and 100 mg/ml penicillin/streptomycin for 24 hours. The L929 fibroblast cells were plate (25.000 cells/ml) in well plates, and maintained in a CO2 incubator at 37°C for 24h. After 24 hours, the incubation medium was replaced by the immersed medium in which the samples were stored and the L929 fibroblasts were incubated in contact with eluates for 24 hours at 37°C for 24h. The fibroblast cell viability was analyzed by measuring the mitochondrial activity with the methyltetrazolium test (MTT). Twelve well used for each specimen and experiment repeated for two times. The data was statistically analyzed by Mann-Whitney U tests.Results: The results showed that, Revotek LC and Protemp 3 Garant were not cytotoxic for fibroblast cells when compared to control group (P>.05). However, Tempofit duomix was cytotoxic for L929 fibroblasts when compared to control group and other tested materials (P%.05).Conclusions: Taking into consideration the limitations of an in vitro study, our study indicate that provisional restoration materials might have cytotoxic effects on fibroblasts and should be selected carefully for clinical applications. (Eur J Dent 2009;3:114-119)
Efficiency of Amorphous Calcium Phosphate–Containing Orthodontic Composite and Resin Modified Glass Ionomer on Demineralization Evaluated By a New Laser Fluorescence Device
Authors: Uysal Tancan , Amasyali Mihri , Koyuturk Alp Erdin , Sagdic Deniz 
Published: September 2019

ABSTRACTObjectives: The aim of this in vitro study was to compare the efficacy of Amorphous Calcium Phosphate (ACP)-containing orthodontic composite and resin-modified glass ionomer cement (RMGIC) on enamel demineralization adjacent to orthodontic brackets evaluated by a new laser fluorescence device.Methods: Sixty extracted maxillary premolars were used in the present study. Twenty orthodontic brackets were bonded with ACP-containing orthodontic adhesive (Aegis-Ortho), 20 were bonded with RMGIC (Fuji Ortho LC) ad20 were bonded with Transbond XT composite as the control. All samples were then cycled for 21 days through a daily procedure of demineralization for 6 hours and remineralization for 17 hours. After this procedure, demineralization evaluations were undertaken by a pen-type laser fluorescence device (DIAGNO-dent Pen). Analysis ofvariance (ANOVA) and Tukey test was used for statistical evaluation, at P<.05 level.Results: According to ANOVA, significant demineralization variations (ΔD) were determined among groups (F=6.650; P<.01). The ACP-containing composite showed the lowest (mean: 8.98±2.38) and the control composite showed the highest (mean:12.15±3.83) ΔD, during 21 days demineralization process (P<.01). Significant difference was also observed between the ΔD scores of the RMGIC (mean: 9.24±2.73) and control (P<.05).No significant differences was found in preventive effects of ACP-containing composite and RMGIC (P<.05) against demineralization.Conclusions: The use of both ACP-containing orthodontic composite and RMGIC should be recommended for any at-risk orthodontic patient to provide preventive actions and potentially remineralize subclinical enamel demineralization. (Eur J Dent 2009;3:127-134)
Effect of Thermo-mechanical Load Cycling on Microleakage in Class II Ormocer Restorations
Authors: Erdilek Dina , Dörter Can , Koray Fatma , Kunzelmann Karl-Heinz , Efes Begum Guray , Gomec Yavuz 
Published: September 2019

ABSTRACTObjectives: The objective of this in vitro study was to evaluate the marginal sealing ability of an ormocer in comparison with a hybrid composite when using thermocycling and load cycling procedures together in the study design.Methods: Modified proximal Class II cavities were prepared on the mesial and distal surfaces of twenty-two human premolars. Each tooth was restored with Admira and contralaterally with TPH Spectrum. Half of all of the teeth were subjected to thermo-mechanical load cycling. After dye penetration, longitudinal sections in mesio-distal direction were prepared and examined under a stereomicroscope. Data were analyzed with Mann Whitney U test.Results: The results showed that the thermo-mechanical load cycling caused a statistically significant increase in gingival microleakage when compared with the non-thermocycled and nonloaded restorations for both the materials Admira (P=0.006) and TPH Spectrum (P=0.023).Conclusions: Simultaneous load cycling and thermocycling are decisive factors in the in vitro assessment of gingival microleakage, which still remains to be a clinical problem even with the ormocer system Admira. (Eur J Dent 2009;3:200-206)
Impacted Mandibular Permanent Incisors Associated With a Supernumerary Tooth: A Case Report
Authors: Ozan Fatih , Kara Isa , Ay Sinan 
Published: September 2019

ABSTRACTIn this report, a rare case of impacted mandibular permanent incisors and supernumerary tooth associated with cystic degeneration and its treatment are described. (Eur J Dent 2009;3:324-328)
Hypodontia. Does the Prevalence and
Distribution Pattern Differ in Orthodontic
Patients?
Authors: Sisman Yildiray , Uysal Tancan , Gelgor Ibrahim    Erhan 
Published: September 2019

ABSTRACTObjective: The aim of this study was to document the prevalence of hypodontia in the permanent dentition among a group of Turkish sample who sought orthodontic treatment and to compare present results with the specific findings of other populations. The occurrence was evaluated in relation to gender, specific missing teeth, the location and pattern of distribution in the maxillary and mandibular arches and right and left sides.Materials And Methods: Orthodontic files of 2413 patients (1557 females-mean age: 17.78±5.41 years old and 856 males-mean age:17.02±5.47 years old) which included orthopantomograms, study models, and anamnestic data were examined for evidence of hypodontia.Results: The prevalence of hypodontia was 7.54% (8.09% for female and 6.54% for male). Hypodontia was found considerably more frequently in the maxilla than in the mandible. Similarity in the distribution of missing teeth between the right and left sides was detected. The most frequently missing teeth were the maxillary lateral incisors, followed by the mandibular and maxillary second premolars. The majority of patients had one or two teeth missing, but seldom three or more.Conclusions: Present data for hypodontia were within the wide range reported in the literature.
The findings of patients with hypodontia involving the anterior teeth and others missing more than two teeth in the same quadrant were an indication of a great need for orthodontic treatment. By early detection of missing teeth, alternative treatment modalities can be planned and performed with a multidisciplinary team approach. (Eur J Dent 2007;1:167-173)