bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism Is Not Responsible for Antihypertensive Therapy Induced New Onset of Type 2 Diabetes in Essential Hypertension
Authors: Jhawat Vikas , Gupta Sumeet , Agarwal Bimal K , Roy Partha , Saini Vipin 
Published: January 2019

Background: Antihypertensive drug therapies have been reported to be associated with new onset of type 2 diabetes mellitus in some hypertensive patients after prolonged use. Angiotensin converting enzyme (ACE) gene has been found to affect essential hypertension, response of antihypertensive therapies, and glycemic disturbances. Therefore, ACE gene I/D polymorphism may be associated with risk of new onset of type 2 diabetes via metabolic disturbances, glycemic dysregulation, and insulin resistance. Aim: To assess the correlation between ACE gene I/D polymorphism and glycemic disturbance under influence of diuretic and other antihypertensive drug therapies. Materials and methods: We recruited 270 normotensive patients as control (150 men and 120 women), 270 hypertensive patients (95 men and 175 women), and 240 hypertensive with new onset of diabetes patients (80 men and 160 women). All samples were genotyped for ACE gene polymorphic alleles and relationship between different genotypes and anthropometric and clinical parameters along with drug therapies was established and analyzed. Results: Baseline clinical (systolic blood pressure, diastolic blood pressure, and fasting blood glucose level) and anthropometric parameters (height, weight, waist circumference, hip circumference, waist-hip ratio, and body mass index) of study populations were found highly statistically significant ( P < .05) when compared among study groups. Furthermore, genotype wise comparison of all these parameters in essential hypertensive (EH) and essential hypertensive with onset of diabetes (EHNOD) patients found most of them nonsignificant and no variation was found with respect to different genotypes of ACE gene. The genotype wise comparison of clinical parameters among different antihypertensive drug therapy was found statistically nonsignificant in both EH and EHNOD patients. Discussion: Anthropometric parameters can be taken as the risk indicator factors for hypertension and diabetes. However, ACE gene polymorphism may not be a risk factor for development of diabetes in hypertensive patients. Conclusion: The present study suggested that ACE gene polymorphism did not show any significant association with the risk of new onset of diabetes in EH patients and more detailed studies with large population size are needed. [Formula: see text]
Poor Sensitivity of Magnetic Resonance Arthrography to Detect Hip Chondral Delamination: A Retrospective Follow-Up of 227 FAI-Operated Patients
Authors: Konstantinidis George , Mitchell Michael , Boyd Gordon , Coady Catherine , Ghosh Swagata , Wong Ivan 
Published: January 2019

Objective The purpose of this study was to retrospectively assess the frequency and characteristics of acetabular cartilage delamination (CD) in femoroacetabular impingement (FAI) patients and to assess the sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of magnetic resonance arthrography (MRA) in detecting CD based on the radiologist report. Design This is a single-center retrospective review of consecutive patients operated for symptomatic FAI. All of the patients had a 1.5-T MR-arthrogram within 12 months preoperatively. MRA reports of these patients were compared with operation notes and surgical videos of all patients by two trained assessors. Results At surgery, CD of the acetabulum was present in 169 patients out of a total of 229 patients (74%). Only 6.5% (11 patients) of CD was described on the MRA reports preoperatively. The mean age of the patients was 37.6 ± 13.3 years. The average extent of delamination was 3.12 ± 1.5 cm2 with a mean coronal × sagittal extent of 0.68 × 4.33 cm. There was a significant difference regarding age ( P = 0.002), alpha angle from frog view ( P = 0.002), and alpha angle from anteroposterior view ( P = 0.012) between the patients with delamination and without delamination. The majority of labral tears and cartilage damage were located in the anterosuperior quadrant. MRA sensitivity was 6%, specificity 98%, NPV 27%, and PPV 91% based on the radiologist report. Conclusion The CD in patients with FAI can be severely underdiagnosed with MRA. There is a need for better standard diagnostic criteria to detect CD in patients with FAI.
Effect of Sphenopalatine Ganglion Block With Bupivacaine on Postoperative Pain in Patients Undergoing Endoscopic Sinus Surgery
Authors: Rezaeian Ahmad , Hashemi Seyed Mostafa , Dokhanchi Zeinab Sadat 
Published: January 2019

Background Postoperative pain is one of the most complications in endoscopic sinus surgery. We aimed to evaluate the effect of the sphenopalatine ganglion block (SPGB) with bupivacaine on postoperative pain in patients undergoing endoscopic sinus surgery. Methods and Materials: In this clinical trial, 40 patients who indicated functional endoscopic sinus surgery were selected and then divided into 2 parallel groups as intervention and control. The intervention group was received 1.5 mL of bupivacaine 0.5% (injected to sphenopalatine ganglion) and while control was injected 1.5 mL of normal saline at the same injection site. Also, the visual analogue scale (VAS) was recorded immediately after anesthesia, along with 6, 12, 24, 48 h, 7 days, and 21 days after the operation for all patients. Results Immediately after anesthesia, as well as 6, 12, and 24 h after the operation, VAS in the intervention group was significantly lower than in the control group ( P < .05, for all). However, there were no significant differences between the 2 groups regarding VAS 48 h as well as 7 and 21 days after surgery ( P > .05, for both). Also, the rescue analgesia in the intervention group was significantly lower than in the control group ( P = .01). Conclusion SPGB with bupivacaine 0.5% (1.5 mL) was a simple, effective, safe, and noninvasive method for the management of postoperative pain in the patients undergoing endoscopic sinus surgery.
Does Mechanical Bowel Preparation Ameliorate Surgical Performance in Anterior Lumbar Interbody Fusion?
Authors: Jeon Chang-Hoon , Lee Han-Dong , Chung Nam-Su 
Published: January 2019

Study Design: Retrospective case-control study. Objectives: To investigate whether mechanical bowel preparation (MBP) improve surgical performance and decrease operative complications in anterior lumbar interbody fusion (ALIF). Methods: This study involved a retrospective analysis of 48 consecutive patients who underwent ALIF with MBP and a control cohort of 50 consecutive patients who underwent the same surgeries without MBP. The quality of each surgical procedure, operative time, estimated blood loss (EBL), intraoperative complications, changes in vital signs and patient symptoms on the day of surgery, and bowel function postoperatively were also compared between the procedures. Results: Baseline demographic characteristics were similar between the 2 groups (all Ps > .05). The quality of each procedure, operative time, EBL, intraoperative complications, and changes in body temperature and heart rate were not different between the groups (all Ps > .05). The MBP group showed more headache, tiredness, thirst, and abdominal discomfort (all Ps < .001) and decrease of the systolic blood pressure ( P = .041) on the day of surgery. The return of bowel movement was not different between the groups ( P = .278). Conclusions: Given the similar surgical result with the substantial patient discomfort, MBP can be omitted in ALIF.
Desimplification of Single Tablet Antiretroviral (ART) Regimens—A Practical Cost-Savings Strategy?
Authors: Krentz Hartmut , Campbell Shayna , Gill John 
Published: January 2019

Introduction: The use of lifelong antiretroviral therapy (ART) results in increased costs of care; the ability to finance and control sustained costs of ART needs to be discussed. Approach: The Southern Alberta Clinic initiated a practical cost savings approach that switched select patients from a branded ART to a less expensive generic variation. Our approach surveyed physicians and patients on their acceptance of switching and then launched a program asking patients if they would switch to generic variations for cost control purposes. Results: Our early findings found >50% of patients approached agreed to switch. We found no evidence of increased risk of viral breakthrough, resistance, side effects, or displeasure with generic drugs. Measured cost savings in the first year were >$1.1 million with annual projected savings of between $4.3 million and $2.6 million (in 2017 Cdn$). Conclusion: Our approach can provide an option for controlling costs of HIV care without compromising quality.
Microplastics in the surface sediments from the eastern waters of Java Sea, Indonesia
Authors: Yona Defri , Sari Syarifah Hikmah Julinda , Iranawati Feni , Bachri Syamsul , Ayuningtyas Wulan Cahya 
Published: January 2019

Background: This study aimed to investigate the abundance of microplastics in the eastern water of Java Sea. The study areas are well known for the high population and high industrial activities that can contribute to the plastic pollution. Methods: Microplastics were sampled from the surface sediments at five different stations representing different local activities: fish landing area (St 1), mangrove forest (St 2), abandoned shrimp pond (St 3), river mouth (St 4) and open sea (St 5). Results: Three types of microplastics were found; the most common was plastic fragments (54.34±6.39%) followed by fibers (41.45±4.59%) and films (4.21±3.90%). The highest abundance of microplastics was observed in the mangrove area (896.96±160.28 particles/kg), dominated with fragments and fibers. Films were found in greatest quantities in the fish landing area, but compared to the other types of microplastics, the abundance was much lower (80.73±37.62 particles/kg). Domestic wastes and fisheries activities were the main causes of the high microplastics in the study areas. Conclusions: The results of this study showed that microplastic pollution is a serious problem that needs to be paid attention not only from the government but also from the local people. Plastics management waste is needed.
Backward walking effects on activation pattern of leg muscles in young females with patellofemoral pain syndrome
Authors: Abdelraouf Osama R , Abdel-Aziem Amr A , Ahmed Alaa A , Nassif Nagui S , Matar Ayman G 
Published: January 2019

Background/Aims: Little is known regarding the activation of knee and hip muscles during backward walking in patellofemoral pain syndrome. This study examineD the effects of backward walking and forward walking on the activation of knee extensors, hip abductors, and adductors in patients with patellofemoral pain syndrome. Methods: A total of 20 females with patellofemoral pain syndrome and 20 age-matched typically healthy female controls participated in this study. Surface electromyography from vastus medialis obliquus, vastus lateralis, gluteus medius, and adductor longus muscles were collected during forward walking and backward walking. Findings: The patellofemoral pain syndrome group had a significantly higher normalised root mean square of the vastus medialis obliquus, vastus lateralis and gluteus medius muscles (P=0.001), without significant difference in adductor longus muscle activity during backward walking versus forward walking (P=0.098). During forward walking, the patellofemoral pain syndrome group showed significantly higher activation of adductor longus muscle (P=0.001) and significantly lower activation of the gluteus medius muscle (P=0.002) compared to the healthy group. During backward walking there was a significant increase in the vastus medialis obliquus and adductor longus muscle activity of the patellofemoral pain syndrome group compared to the control group (P=0.003, 0.001) respectively. Conclusions: Clinicians should consider backward walking training to increase the muscle strength of knee extensors and hip abductors when developing rehabilitation programmes for patients with patellofemoral pain syndrome.
Exploring the impact of individual differences in aural vocabulary knowledge, written vocabulary knowledge and working memory capacity on explaining L2 learners’ listening comprehension
Authors: Masrai Ahmed 
Published: January 2019

Abstract
Listening comprehension constitutes a considerable challenge for second language learners, but little is known about the relative contribution of individual differences in distinct factors to listening comprehension. Since research in this area is relatively limited in comparison to that focusing on the relationship between reading comprehension and factors such as vocabulary knowledge and working memory, there is a need for studies that seek to fill the gap in our knowledge about the specific contribution of aural vocabulary knowledge, written vocabulary knowledge and working memory capacity to explaining listening comprehension. Among 130 non-native speakers of English, the present study examines what proportion of the variance in listening comprehension is explained by aural vocabulary knowledge, written vocabulary knowledge, and working memory capacity. The results show that aural vocabulary knowledge is the strongest predictor of listening comprehension, followed by working memory capacity, while written vocabulary knowledge contributes only marginally. The study discusses implications for the explanatory power of aural vocabulary knowledge and working memory to listening comprehension and pedagogical practice in second language classrooms.
Prospects of Pharmacological Interventions to Organismal Aging
Authors: Hillson Olivia , Gonzalez Suam , Rallis Charalampos 
Published: January 2019

AbstractIntense research in the areas of cellular and organismal aging using diverse laboratory model systems has enriched our knowledge in the processes and the signalling pathways involved in normal and pathological conditions. The field finds itself in a position to take decisive steps towards clinical applications and interventions not only for targeted age-related diseases such as cardiovascular conditions and neurodegeneration but also for the modulation of health span and lifespan of a whole organism. Beyond nutritional interventions such as dietary restriction without malnutrition and various regimes of intermittent fasting, accumulating evidence provides promise for pharmacological interventions. The latter, mimic caloric or dietary restriction, tune cellular and organismal stress responses, affect the metabolism of microbiome with subsequent effects on the host or modulate repair pathways, among others. In this mini review, we summarise some of the evidence on drugs that can alter organismal lifespan and the prospects they might offer for promoting healthspan and delaying age-related diseases.
Reading UAE Contract Law through the Lens of Islamic Jurisprudence: A Case Study on the ‘Extraneous Cause’ Exception in the UAE Civil Code
Authors: Jadalhaq Iyad Mohammad , El Maknouzi Mohammed El Hadi 
Published: January 2019

Abstract
This article reveals the different formative layers at work in a mixed system of law, such as that of private law in the United Arab Emirates (uae), by focusing on the lack of coherence between competing ‘architectural principles’. This experience of friction is regularly encountered by a skilled interpreter of the law, in the course of his/her activity of ensuring predictable and appropriate legal responses to practical problems. Specifically, this piece tracks the interpretive difficulties surfacing in cases of supervening impossibility of performance for loss or damage to a necessary item, when that loss or damage originates in a causal factor outside of the defendant’s sphere of control (‘extraneous cause’). In such cases, the contract is terminated and the legal question shifts to one of awarding compensation for the loss or damage suffered by the item. In the face of this question, two competing criteria for assigning liability come into play. On the one hand, the civil law distinction between unilateral and bilateral contracts, meaning contracts giving rise to obligations upon only one or both parties to the contract. On the other hand, the categories of trust-based, liability-based and mixed possession in Islamic law. Here, liability is assigned based on the material circumstances that define the manner of possession, as opposed to looking at the abstract scheme of performance and (if available) counter-performance. The categories drawn from Islamic law have the potential to unify a number of apparently scattered provisions in the uae Civil Code: for this reason, the article puts forth a recommendation to follow the approach of the Iraqi Civil Code and acknowledge those categories as an explicit organising principle for assigning liability in the presence of an extraneous cause. The paper makes an additional recommendation to treat the classification of possession (as trust-based or liability-based) as a matter of public policy, unavailable for the parties’ consensual deviation.
Computational design of structured loops for new protein functions
Authors: Kundert Kale , Kortemme Tanja 
Published: January 2019

Abstract
The ability to engineer the precise geometries, fine-tuned energetics and subtle dynamics that are characteristic of functional proteins is a major unsolved challenge in the field of computational protein design. In natural proteins, functional sites exhibiting these properties often feature structured loops. However, unlike the elements of secondary structures that comprise idealized protein folds, structured loops have been difficult to design computationally. Addressing this shortcoming in a general way is a necessary first step towards the routine design of protein function. In this perspective, we will describe the progress that has been made on this problem and discuss how recent advances in the field of loop structure prediction can be harnessed and applied to the inverse problem of computational loop design.
Crystal structure of coordination polymer catena-poly[diaqua-(2,6-dichloropyridine-4-carboxyliato-κ2
O,O′)-bis(μ2-2,6-dichloropyridine-4-carboxyliato-κ2
O:O′)terbium(III), C18H10Cl6N3O8Tb
Authors: Liu Guang-Zhen , Xin Ling-Yun , Li Xiao-Ling 
Published: January 2019

Abstract
C18H10Cl6N3O8Tb, monoclinic, I2/a (no. 15), a = 9.8281(2) Å, b = 11.8792(2) Å, c = 21.1568(4) Å, β = 91.1599(19)°, V = 2469.54(9) Å3, Z = 8, R
gt(F) = 0.0196, wR
ref(F
2) = 0.0473, T = 293(2) K.
Crystal structures, Hirsfeld surface analysis and a computational study of four ethyl 2-oxo-2H-chromene-3-carboxylate derivatives: a survey of organyl 2-oxo-2H-chromene-3-carboxylate structures
Authors: Gomes Ligia R. , Low John N. , van Mourik Tanja , da Silveira Pinto Ligia S. , de Souza Marcus V.N. , Wardell Jámes L. 
Published: January 2019

Abstract
Crystal structures, Hirshfeld surface analysis and a computational study have been carried out on 2-oxo-2H-chromene-3-carboxylates. Crystal structures are reported for ethyl R-2-oxo-2H-chromene-3-carboxylate derivatives, 2a: R=6-Me, 2b: 7-Me, 2c: 7-Me, 2d: R=7-MeO. In contrast to 2-oxo-2H-chromene-3-carboxamides, 1, in which classical intramolecular N–H···O hydrogen bonds stabilize planar structures and hinder rotation of the amido group out of the coumarin plane in 2, without an equivalent hydrogen bond, there is a greater rotational freedom of the carboxylate group. The interplanar angles between the coumarin core and its attached –C(O)–R substituent in crystalline 2a, 2b, 2c and 2d are 10.41(6), 36.65(6), 10.4(2) and 5.64(6)°, respectively, with distances between the carbonyl oxygen atoms of 2.8255(16), 2.9278(16), 4.226(2) and 2.8328(14) Å, respectively. A theoretical study of molecular conformations was carried out at the M06-2X density level with the 6-31+G(d) and aug-cc-pVTZ basis sets, in methanol solution modeled by PCM, indicated that the most stable conformations had the carbonyl group of the ester in the plane of the coumarin core: the s-cis arrangement of the ester carbonyl and the 2-oxo moieties being the slightly more stable than the s-trans form by less than 0.5 kcal/mol. The experimental conformations of 2a and 2d match well the low energy s-cis arrangement, and 2c matches the slightly lesser stable s-trans arrangement found in the theoretical study. A survey of the molecular conformations of more than 50 2H-chromene-3-carboxylates derivatives in the CCDC data base indicated two distinct groupings of conformations, s-cis and s-trans, each with interplanar angles <30°.
Apartheid
Authors: Chidester David 
Published: January 2019

Apartheid was established in South Africa between 1948 and 1994 as a force of exclusion and incorporation, excluding people from citizenship and exploiting people as labor. This chapter suggests that the term apartheid, meaning “separation,” was formative for certain ways of thinking about religion. One of the architects of apartheid, the anthropologist W. M. Eiselen, was a leading expert on indigenous religions in South Africa. Eiselen’s writings on African religion illustrate three overlapping types of comparative religion—a frontier comparative religion based on denial and containment; an imperial comparative religion assuming evolutionary progress from savagery to civilization; and an apartheid comparative religion creating and reinforcing boundaries to keep people apart. Although apartheid was formally established as a racist policy of separation in South Africa, the making and maintaining of boundaries has been a recurring feature of religious formations.