bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENELUSURAN MEKANISME FLAVONOID KULIT JERUK KEPROK (Citrus reticulata) SEBAGAI AGEN KEMOPREVENTIF MELALUI DOCKING MOLEKULER PADA PROTEIN TARGET CYP1A2
Authors: Andita Pra Darma, Riris Istighfari Jenie, Edy Meiyanto Perdana Adhi Nugroho, Dyani P Sukamdi, 
Published: January 2019

Subklas flavonoid khususnya golongan polimetoksiflavon menunjukan aktivitas kemopreventif pada berbagai sel kanker secara in vitro dan beberapa studi in vivo. Pada tahapan inisiasi kanker, bioaktivasi karsinogen polisiklik aromatik hidrokarbon secara signifikan dapat direduksi oleh senyawaan polimetoksiflavon melalui penghambatan sistem enzim sitokrom P450 (CYP) dalam level transkripsi gen maupun interaksi langsung dengan enzim tersebut. Pada tahapan promosi kanker, berbagai studi menunjukan bahwa proliferasi sel kanker dihambat lebih kuat oleh golongan metoksiflavon dibandingkan hidroksiflavon. Tangeretin, nobiletin, naringin dan hesperidin adalah beberapa senyawa polimetoksiflavon dari kulit jeruk keprok yang dilaporkan memiliki efek kemopreventif melalui modulasi aktivitas CYP1A2. Penelitian ini bertujuan untuk mengetahui afinitas, konformasi dan interaksi senyawa berkerangka polimetoksiflavon kulit jeruk keprok (Citrus reticulata) terhadap protein target CYP1A2 menggunakan molecular docking. Optimasi geometri struktur polimetoksiflavon dilakukan dengan piranti lunak Molecular Operating Environment for Windows. Konformasi optimum struktur polimetoksiflavon dihasilkan menggunakan metode semiempirik AMBER99. Kemudian dilakukan proses docking senyawa uji dengan bindingsite CYP1A2 (PDB ID:2HI4) menggunakan piranti lunak Molecular Operating Environment for Windows dalam kondisi tanpa air. Hasil docking senyawa golongan polimetoksiflavon dibandingkan dengan native ligan pada target CYP1A2, menunjukkan interaksi polimetoksiflavon yang lebih kuat dibanding interaksi ligan pembanding á-naphtoflavon. Kata kunci: Citrus reticulata, polimetoksiflavon, molecular docking, CYP1A2
FORMULASI SUSPENSI DOKSISIKLIN MENGGUNAKAN SUSPENDING AGENT PULVIS GUMMI ARABICI: UJI STABILITAS FISIK DAN DAYA ANTIBAKTERI
Authors: Chasanah Nur , Trisharyanti DK Ika , Indrayudha Peni 
Published: January 2019

Suspension is a dosage contain solid drug material with insoluble form and smooth. Doxycycline is an antibiotic which difficult dissolve in water. Stable doxycycline suspension during 2 week if it kept at space temperature, stable on the air but will change to be dark if it influence sunshine. The aim of the research to evaluate physical stability and ability antibacterial stability doxycycline suspension with PGA as suspending agent. Research category are: Independent variable : concentration of suspending agent (PGA), suspension holding time. Dependent variable: physical stability (sedimentation volume, viscosity, redispersibility, easy to pour, and particle size) and antibacterial of doxycycline suspension, and variabel control is temperature suspension making, create of suspension. Data collecting with measuring physical stability and ability antibacterial of doxycycline suspension. The result shows doxycycline suspension with suspending agent PGA had physical stability and antibacterial ability is good. Physical Stability test show formula 1 rate PGA 5% is formula had physical stability better than formula 2 with rate PGA 7,5% and formula 3 withrate PGA 10%. stability ability test antibacterial show formula 2 is the best in pursues Staphylococcus aureus.
PERANAN MIKROBA ENDOFIT UNTUK PENGEMBANGAN OBAT ANTI KANKER
Authors: Rofida Siti 
Published: January 2019

Natural product that has developed as anticancer drugs are consists from secondary metabolites that has isolated from plant, ocean plant and microorganisms. To maintain its productivity, must be concerned to the cultivation of the medicinal plants. Medicinal plants need time to grow and producing secondary metabolites that would be isolated, so that the production of secondary metabolites compound from plant is very limited. The plants that infected by endophytic fungi be able to grow faster than the normal plants. Endophytic fungi also have ability producing secondary metabolites compound that produced by the host plant. Taxol, podophyllotoxin and camptothecin are compounds that proved has anticancer activity. Endophytic fungi have also proved increasing the production of the compound.
EFEK KEFIR TERHADAP GAMBARAN HISTOLOGIS DAN KADAR MALONDIALDEHIDE HEPAR MENCIT PUTIH (MUS MUSCULUS) JANTAN GALUR BALB C DENGAN PAPARAN FORMALIN
Authors: Ni Made Dwi Aryantini Erna Susanti 
Published: January 2019

Kefir is a probiotic drink act as therapeutic agents in liver damage caused by exposure of formaldehyde. Therapeutic activities were estimate based on the content of kefir like antioxidants, lactic acid bacteria with yeasts, and essential amino acids. The purpose of this study was to prove the influence of kefir on the histological and levels of malondialdehyde (MDA) in liver of white mice (Mus musculus) male Balb C strain that exposure by formalin. The method used is experimental method, with three treatment groups, namely: (1) normal group, (2) the induction of formaline without kefir therapy group, (3) the induction of formaline with kefir therapy group. Histological of liver viewed by HE staining and MDA levels were measured by TBARS method. There are differences in the average number of significant cell damage induced by formalin group (p = 0030, p < 0.05). There are significant differences in MDA levels induced by formalin group (p = 0023, p < 0.05). These results are based on the ability of vitamin C, E and carotene (antioxidant) against Reactive Oxygen Species (ROS) due to exposure of formaldehyde, thus preventing the MDA levels increasing. Lactic acid bacteria and yeasts can preclude the possibility of healthy cells to be attacked by ROS with increasing the body’s immunity. Essential amino acids can repairing damaged cells by stimulating cell regeneration. It can be concluded that kefir with a dose of 107 CFU / ml act as therapeutic agents in liver damage due to exposure to formaldehyde.
Determination Of Curcumin In Capsule Containing Curcuma xanthorrhiza Roxb. Extracts By High Performance Liquid Chromatography
Authors: Kurniawan Firdaus Candra 
Published: January 2019

Curcumin, the major yellow pigment of Curcuma sp. has several interesting biological activities, such as anticarcinogenecity, antiinflamatory, and antioxidant. Curcumin naturally occurs as major compound in Curcuminoid substance beside its derivatives, i.e. Bisdemethoxycurcumin (BDC) and Demethoxycurcumin (DC). Quantitative analysis of Curcumin is difficult to carry out unless prior to completely resolved Curcumin from BDC and DC. A good resolution, reproducible, and accurate method for determination Curcumin in pharmaceutical product (capsule formed) by HPLC has been carry out. Using C18 colurnn and mixture of Acetonitrile: Acetic Acid glacial 1% (45:55 v/v) as eluent, BDC, DC, and Curcumin were retained with retention time of 10.79, 12.29, and 13.91 minutes, respectively. Curcumin was simultaneously separated from BDC or DC. The resolution factor (Rs) between Curcumin and DC was 1.73. Good linear relationship (r = 0.9997, Vxo = 0.99%) between peak area and concentrations was found at range of the Curcumin concentration used, i.e. 23.56-62.83 µg/mL. Curcumin recoveries were (93.60-118.17)% with the coefficient of variation (CV) 6.99%. Curcumin content in each capsule sample was found to be (8.89±0.06) mg. It showed that samples contained higher amount of Curcumin than that claimed on its label, 5 mg.
USING OF ROUTINE MRI SEQUENCES FOR EVALUATION OF IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS
Authors: Gavrilov G. V. , Stanishevskiy A. V. , Gaydar B. V. , Svistov D. V. , Adleyba B. G. 
Published: January 2019

Idiopathic normal pressure hydrocephalus (Hakim-Adams syndrome, iNPH) is a chronic neurodegenerative disease of elderly associated with ventricular expansion, and characterized by gait disturbance, mental deterioration, and urinary incontinence. It becomes more important with increasing of elderly part of population. Important feature of iNPH is it’s reversibility in case of early surgical treatment. One of the main problem is the differential diagnosis between iNPH and other neurodegenerative diseases and detection of patients which would be most benefit with shunting. In this purpose a number of radiological symptoms and signs have been proposed. Assessment of MR symptoms of iNPH increases the accuracy of diagnosis and allows in some cases to avoid the necessity of invasive diagnostic procedures (e.g. tap-test, infusion test, external lumbar drainage, ICP monitoring etc.) with lower risk of complications, less duration of treatment and minimizing negative personal experience. At the same time, assessing of most sensitive iNPH radiological symptoms allows to evolve candidates for shunting at prehospital stage and reduce the duration of treatment.Background and purpose:systematization and synthesis of data on radiological symptoms of iNPH in order to identify most simple and at the same time significant diagnostic and prognostic criteria.Matherials and methods.The search was performed in PubMed, Google Scholar and Cochrane Library by key words «normal pressure hydrocephalus», «neuroimaging», «magnetic resonance imaging», «computed tomography, radiological symptoms». In addition, data from references were used.Results.Most specific and sensitive radiological criteria for diagnosis of iNPH are following: Evans index, DESH, temporal horns dilation, callosal angle, periventricular edema, perivascular spaces dilation and local sulci dilation. Complex assessment of this symptoms increases diagnostic accuracy and in some cases allows to avoid the necessity of invasive diagnostic procedures.
THE EFFECT LOW LEVEL LASER THERAPY FOR MANAGEMENT OF RADIATION-INDUCEED MUCOSITIS
Authors: Sedova E. S. , Jusupov V. I. , Vorobieva N. N. , Kanischeva N. V. , Chernyavskii A. A. , Maslennikova A. V. , Kuznetsov A. D. 
Published: January 2019

Low-level laser therapy as a method for correcting the mucositis caused by ionizing radiation of the oral mucosa is used in clinical practice for various exposure parameters: radiation power not less than 10 mW, laser doses not less than 2 J/cm2. The purpose of this study was to compare the efficacy of low-level laser therapyred and infrared laser radiation for the correction of mucositis of the oral mucosa in patients receiving radiation and chemoradiotherapy for oral and pharyngeal cancer, with laser doses of less than 1 J/cm2. The study included 106 patients who received radiation and chemoradiotherapy for cancer of the oral cavity and pharynx, which were randomly divided into three groups. In the first (37 patients), mucositis was prevented and corrected in accordance with the standards of the clinic, in the second (36 patients) and the third (33 patients), patients were additionally exposed to the oral cavity with Low-level laser therapy (LLLT) at 635 nm and 780 nm at powers of 5 mW and 20 mW, respectively. The effect of LLLT on the wavelength of 635 nm significantly reduced the frequency and severity of mucositis, increased the time until the appearance of the first symptoms of mucositis of the oral mucosa, shortened the duration of severe mucositis (grade 3), and reduced the need for painkillers, including narcotic analgesics compared with the group who received standard prophylaxis and correction of mucositis.
Estudio AB-Initio de las propiedades estructurales y electrónicas de la doble Perovskita Ba2InTaO6
Authors: Deluque Toro Crispulo Enrique , Landinez Tellez David Arsenio , Rodriguez Martinez Jairo Arbey , Roa Rojas Jairo 
Published: January 2019

Los materiales de tipo Perovskita doble con fórmula genérica A2BB’O6 han sido ampliamente estudiados en los últimos años debido a su gran versatilidad, la cual permite la inclusión de iones de tipo alcalino térreo en los sitios A de la estructura y metales de transición en los sitios B y B’, dando origen a diversas propiedades físicas que redundan en múltiples aplicaciones industriales. En este trabajo estudiamos las propiedades estructurales y electrónicas del compuesto Ba2InTaO6, el cual es de particular interés ya que dichos sistemas podrían aplicarse en el desarrollo de resonadores dieléctricos y filtros para señal de microondas en teléfonos móviles y otros dispositivos inalámbricos, entre otras. Mediante modelamiento computacional ab-initio, basado en la Teoría de Funcional Densidad (DFT), y partiendo de la estructura de grupo espacial Fm-3m, evaluamos los parámetros de red, las energías de equilibrio y la ecuación de estado entre otras cantidades. La minimización de la energía en función del volumen permite la obtención de un parámetro de red de 15.861 Bohr. Los resultados de la Densidad de Estados Electrónicos (DOS) muestran que la doble Perovskita Ba2InTaO6 tiene un gap indirecto de ~ 4.25 eV.Palabras clave: Doble Perovskita, AB-Initio, estructura electrónica.Abstract The double Perovskites materials with the formula A2 BB’O6 has been studied thoroughly in the past years due to its versatility, which allow to include the alkaline earth ions in A sites and transition metals in B and B’sites, giving origin to several physical properties with various industrials applications. In this work the structural and electronic properties of Ba2 InTaO6 are studied, material that is particularly interesting due to its possible application to the development of dielectric resonators and microwave signal filters on mobile phones and other wireless devices. Using ab-initio computational model, based on the Density Funtional Theory (DFT), and starting from spacial group Fm-3m, we calculate lattice parameters, equilibrium energies and equations of state among other quantities. The energy minimization as a function of volume allows to obtain a attice constant of 15.861 Bohr. The results of electronic density of states (DOS) show that the double Perovskite Ba2 InTaO6 has an indirect gap of ~ 4.25 eV.Keywords: Double Perovskites, Ba2 InTaO6 , DFT, Electronic structure
Pedagogical Implications of Corpus-based Approaches to ELT in Pakistan
Authors: Zahra Tehseen , Abbas Akhtar 
Published: January 2019

<p>The advent of corpora has opened new vistas for language study and restructured linguists’ and academicians’ approaches to lexicography and English language teaching (ELT). After 1980s, the use of online language corpora and computer tools garnered tremendous attention of English language teachers and academicians. Keeping in view the modern trends and needs of learners, this research focused on the practical implications of online corpora for ELT and its utility in the Pakistani context. Michigan Corpus of Academic Spoken English (MICASE) is used as a reference corpus for this research. MICASE is a collection of nearly 1.8 million words of transcribed speech (almost two hundred hours of recording). The transcribed data of MICASE includes wide range of speech events like seminars, lectures, advisory meetings and lab sessions. The study identified the utility of lexical items at syntactic level and its usage in various contexts. Furthermore, the layers of meanings and uses of lexicons through in-depth study of right and left collocates were explored in the reference corpus. The results showed that lexicons can be used as noun, verb and adjective depending upon the context of the study and right and left collocates play a significant role in understanding the meanings of lexical items in various contexts. Thus, this strategy can be fruitful for English language learners and academic discourse community who are interested in understanding the versatile uses of lexical items and their contextual meaning.</p><p><strong>Keywords:</strong> collocate, context, corpus, ELT, MICASE</p>
Failure in Quality of Academic Performance of Students in Public Sector Schools of Sheikhupura
Authors: Abdullah Nauman A , Bhatti Nargis 
Published: January 2019

<p align="left">Concerns have been raised about the failure of students in quality of academic performance in public sector school over the past few years. Therefore, this research study was conducted to explore the factors which affect the quality of academic performance of students in public sector schools. Mixed methods research design was used to explore this phenomenon in the district Sheikhupura. Using multi-stage random sampling techniques out of 45 boys and girls school in the district 10 boys’ and 10 girls’ schools were selected. All stakeholders— students, parents, teachers, and heads from those schools were selected in the sample of total 300. Quantitatively close ended self-developed questionnaires were used to collect data from 120 students and 120 parents. Qualitatively semi-structured interviews were used to generate data from the participants—40 teachers and 20 heads from the schools. Descriptive and inferential statistical techniques and thematic description approach was used to analyze the different data sets. Various causes of students’ failure and remedial suggestions were discovered in the analysis. The results have serious implications for school education department of the province, Punjab. </p><p align="left"><strong>Keywords:</strong> academic performance, failure, public sector schools, students</p>
ACCESS TO HIGHER EDUCATION: SOURCE OF GRADUATE EMPLOYABILITY AND WELLBEING
Authors: Bakari Haroon , Hunjra Ahmed Imran 
Published: January 2019

<p>Access to higher education has been the subject of considerable debate among policy makers and academicians. But the concept lacks empirical evidence regarding its impact upon students and societal outcomes. This study provides empirical answer to the research question: how do access to higher education and teachers’ support relate to graduates’ self-perceived employability and psychological wellbeing? The data were collected from 520 students of bachelors and master’s programs in rural campuses of an oldest University of Pakistan and analyzed through Structural Equation Modelling (SEM) using AMOS and SPSS software. Results reveal that access to higher education and teachers support are positively related with selfperceived employability of graduating student with little or no difference among gender. Whereas, teachers support also contributes to psychological wellbeing of the students. The impact of access to higher education on psychological wellbeing was insignificant. This study provides implications for universities, policy makers, and human resource management professionals regarding enhancement of graduate employability.</p><p> </p><p><strong>Keywords:</strong> access to higher education, psychological well-being, self-perceived<br />employability, teachers’ support</p>
Comparing Traditional Teaching Method and Experiential Teaching Method using Experimental Research
Authors: Raja Farhan Uddin , Khan Najmonnisa 
Published: January 2019

<p>The modern time is shaping a world of opportunities that has glorified the role<br />and functions of multinational organizations across the globe. An individual has<br />become a global citizen, who explores employment opportunities in different<br />countries of the world. This has signified the importance of interpersonal skills that allow individuals to connect with people from different cultures. As a result, the role of business communication instructors has become vital because they impart the skills of communication among their students. For this, instructors’ sensitivity towards the teaching methods used in classrooms are of prime significance. These methods determine the interest level and motivation of students towards learning and acquisition of communication skills. Therefore, this study aims to compare experiential learning method and traditional learning method to explore which method inculcates and improves the communication skills of business administration students of a private sector university. The study was conducted in a quantitative paradigm using an experimental research design. The sample size comprised 60 BBA students from two different sections of business communication courses. The data were collected using a pretest and posttest. For the pretest, communication skills were imparted to both the groups using the traditional teaching method that heavily employed lecturing. For the posttest, the controlled group was taught using the same traditional teaching method while the treatment group was taught using the experiential learning method. Mean scores 20.46 &amp; 19.90 with a significant value of 0.375 for the pretest established identical nature of both groups. Mean scores 27.80 &amp; 30.36 with a significant value of .002 of posttest showed that the two groups under study had different identities in scores, which proved that experiential learning method improves students’ communication skills better than traditional communication skills.</p><p><strong>Keywords:</strong> business communication, experiential learning, experimental research, traditional learning</p>
Using Texts to Teach Cognitive-Affective Curriculum
Authors: Dar Fatima 
Published: January 2019

<p><em>The study addressed a cognitive-affective gap in the textual content of a primary</em><br /><em>English curriculum. The research design was qualitative in nature. In the first part of the study, document analysis of the textbooks from grades1-5 was done to prove that empathetic and pro-social themes were under represented in them. The second part of the study was an intervention in which teachers were apprised to highlight empathetic and pro social themes in texts and teach them. The third part of the study noticed if the use of cognitive-affective texts raised awareness among students about the said themes and significantly affected their interest in academic work. The findings from document analysis, observations and interviews indicated that empathetic and pro-social themes were under represented in the textual content. The observations of integrated cognitive-affective lessons brought forth a significant increase in student interest in academic work and raised awareness about the stated themes. This was also authenticated by teachers and students in focused group interviews. The study was significant in terms of raising the importance of the stated skills at the primary level and prove that cognitive-affective use of textual content in schools could raise awareness about affective skills and prepare helpful and caring individuals for the society.</em></p><p><em><br /></em></p><p><strong>Keywords:</strong> cognitive-affective, curriculum, empathy, social-emotional learning,<br />textual content</p><p><em><br /></em></p>