bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue-Specific Transcriptome Analysis Reveals Candidate Genes for Terpenoid and Phenylpropanoid Metabolism in the Medicinal PlantFerula assafoetida
Authors: Amini Hajar , Naghavi Mohammad Reza , Shen Tong , Wang Yanhong , Nasiri Jaber , Khan Ikhlas A , Fiehn Oliver , Zerbe Philipp , Maloof Julin N 
Published: January 2019

AbstractFerula assafoetida is a medicinal plant of the Apiaceae family that has traditionally been used for its therapeutic value. Particularly, terpenoid and phenylpropanoid metabolites, major components of the root-derived oleo-gum-resin, exhibit anti-inflammatory and cytotoxic activities, thus offering a resource for potential therapeutic lead compounds. However, genes and enzymes for terpenoid and coumarin-type phenylpropanoid metabolism have thus far remained uncharacterized in F. assafoetida. Comparative de novo transcriptome analysis of roots, leaves, stems, and flowers was combined with computational annotation to identify candidate genes with probable roles in terpenoid and coumarin biosynthesis. Gene network analysis showed a high abundance of predicted terpenoid- and phenylpropanoid-metabolic pathway genes in flowers. These findings offer a deeper insight into natural product biosynthesis in F. assafoetida and provide genomic resources for exploiting the medicinal potential of this rare plant.
Establishment and Maintenance of Chromatin Architecture Are Promoted Independently of Transcription by the Histone Chaperone FACT and H3-K56 Acetylation in Saccharomyces cerevisiae
Authors: McCullough Laura L , Pham Trang H , Parnell Timothy J , Connell Zaily , Chandrasekharan Mahesh B , Stillman David J , Formosa Tim 
Published: January 2019

Abstract
Using a combination of in vitro biochemistry, genetics, and genomics, McCullough and Pham et al. explore how the histone:DNA contact at the entry/exit site of nucleosomes affects the functions of the histone chaperone FACT in the yeast...
FACT (FAcilitates Chromatin Transcription/Transactions) is a histone chaperone that can destabilize or assemble nucleosomes. Acetylation of histone H3-K56 weakens a histone–DNA contact that is central to FACT activity, suggesting that this modification could affect FACT functions. We tested this by asking how mutations of H3-K56 and FACT affect nucleosome reorganization activity in vitro, and chromatin integrity and transcript output in vivo. Mimics of unacetylated or permanently acetylated H3-K56 had different effects on FACT activity as expected, but the same mutations had surprisingly similar effects on global transcript levels. The results are consistent with emerging models that emphasize FACT’s importance in establishing global chromatin architecture prior to transcription, promoting transitions among different states as transcription profiles change, and restoring chromatin integrity after it is disturbed. Optimal FACT activity required the availability of both modified and unmodified states of H3-K56. Perturbing this balance was especially detrimental for maintaining repression of genes with high nucleosome occupancy over their promoters and for blocking antisense transcription at the +1 nucleosome. The results reveal a complex collaboration between H3-K56 modification status and multiple FACT functions, and support roles for nucleosome reorganization by FACT before, during, and after transcription.
V. Džeimso „radikalusis empirizmas“
Authors: Patkauskaitė Jūratė 
Published: January 2019

Straipsnyje nagrinėjama amerikiečių pragmatizmo filosofijos svarbiausio atstovo W. Jameso pažinimo sampratos svarbiausi bruožai. Filosofas plėtojo vadinamąjį radikalųjį empirizmą, teigiantį, kad visa realybė (fizinė ir psichinė) yra sudaryta iš vienos pirminės – patyrimo – substancijos. Grynasis patyrimas yra sudėtingas nuoseklus darinys, atsiveriantis žmogaus sąmonei iš karto savo tikrąja esme. Pirminiai patyrimo duomenys pasireiškia kaip jutimiškai nepertraukiami, kaip patyrimo srautas. Perėjimas į kitą patyrimą yra vienintelė prieš tai buvusio patyrimo funkcija. Teigiama, kad W. Jameso pažinimo teorijoje nelieka objektyvios subjekto bei objekto tarpusavio sąveikos. Pažintinį santykį šioje teorijoje pakeičia skirtingos reagavimo į įvairius dirgiklius formos ir nerami būsena pačios sąmonės viduje. Daroma išvada, kad, sutelkęs visą dėmesį į individualų patyrimą kaip gnoseologinių problemų sprendimo pagrindą, W. Jamesas iš esmės sukūrė naują subjektyviojo idealizmo variantą.
Newborn Risk Factors for Subsequent Physical Abuse Hospitalizations
Authors: Puls Henry T. , Anderst James D. , Bettenhausen Jessica L. , Clark Nicholas , Krager Molly , Markham Jessica L. , Hall Matthew 
Published: January 2019

OBJECTIVES:
To describe the prevalence of risk factors for abuse and newborns’ risks for physical abuse hospitalizations during early infancy.

METHODS:
We created a nationally representative US birth cohort using the 2013 and 2014 Nationwide Readmissions Databases. Newborns were characterized by demographics, prematurity or low birth weight (LBW), intrauterine drug exposure, and medical complexity (including birth defects). Newborns were tracked for 6 months from their birth hospitalization, and subsequent abuse hospitalizations were identified by using International Classification of Diseases, Ninth Revision codes. We calculated adjusted relative risks (aRRs) with multiple logistic regression, and we used classification and regression trees to identify newborns with the greatest risk for abuse on the basis of combinations of multiple risk factors.

RESULTS:
There were 3 740 582 newborns in the cohort. Among them, 1247 (0.03%) were subsequently hospitalized for abuse within 6 months. Among infants who were abused, 20.4% were premature or LBW, and 4.1% were drug exposed. Premature or LBW newborns (aRR 2.16 [95% confidence interval (CI): 1.87–2.49]) and newborns who were drug exposed (aRR 2.86 [95% CI: 2.15–3.80]) were independently at an increased risk for an abuse hospitalization, but newborns with medical complexity or noncardiac birth defects were not. Publicly insured preterm or LBW newborns from rural counties had the greatest risk for abuse hospitalizations (aRR 9.54 [95% CI: 6.88–13.23]). Publicly insured newborns who were also preterm, LBW, or drug exposed constituted 5.2% of all newborns, yet they constituted 18.5% of all infants who were abused.

CONCLUSIONS:
Preterm or LBW newborns and newborns who were drug exposed, particularly those with public insurance and residing in rural counties, were at the highest risk for abuse hospitalizations. Effective prevention directed at these highest-risk newborns may prevent a disproportionate amount of abuse.
Literatura In Memoriam: sentidos de legitimação histórica
Authors: Moura Edilson Dias 
Published: January 2019

Este artigo tem como objeto os romances Um homem é muito pouco, de Ronaldo Costa Fernandes, e K., de B. Kucinski; e o poema Estação Paraíso, de Alipio Freire. A partir dessas obras, procura-se estabelecer uma reflexão acerca da literatura contemporânea, nos eixos da temporalidade e da memória, como prática de representação cuja finalidade é caracterizar o estado atual do comportamento social brasileiro em face da sua história política recente. *** In memoriam literature: historical legitimation’s senses ***This article aims to analyse the novels “Um homem é muito pouco”, by Ronaldo Costa Fernandes, “K.”, by B. Kucinski; and the poem “Estação Paraíso”, by Alipio Freire. Through the reading of these works we try to establish a reflection on contemporary Brazilian Literature in the theoretical perspectives of temporality and memory studies as a representation practice whose purpose is the characterization of the current state of Brazilian social behavior in the face of its recent History.Keywords: Brazilian literature; contemporary novel; time and memory studies.
Randomized Trial of a Tailored Cognitive-Behavioral Therapy Mobile Application for Anxiety in Patients with Incurable Cancer
Authors: Greer Joseph A. , Jacobs Jamie , Pensak Nicole , MacDonald James J. , Fuh Charn-Xin , Perez Giselle K. , Ward Alina , Tallen Colleen , Muzikansky Alona , Traeger Lara , Penedo Frank J. , El-Jawahri Areej , Safren Steven A. , Pirl William F. , Temel Jennifer S. 
Published: January 2019

Abstract

Background
The aim of this study was to test the efficacy of a tailored cognitive-behavioral therapy (CBT) mobile application (app) to treat anxiety in patients with incurable cancer.

Materials and Methods
Patients with incurable cancers (n = 145) who reported elevated anxiety symptoms at two cancer centers were randomized to receive either the CBT mobile app for anxiety or a mobile health education program (control) delivered via tablet computers, which patients self-administered over 12 weeks. To assess anxiety, depression symptoms, and quality of life (QOL), we used the Hamilton Anxiety Rating Scale (HAM-A, primary outcome), Clinical Global Impression Scale, Hospital Anxiety and Depression Scale (HADS), Patient Health Questionnaire-9, and Functional Assessment of Cancer Therapy-General at baseline and 12 weeks. Analysis of covariance models were calculated to assess intervention effects on patient outcomes.

Results
Patients (73.8% female; 91.0% white; mean age = 56.45 years, SD = 11.30) in both study groups reported improvements in anxiety, depression symptoms, and QOL from baseline to postassessment, with no significant differences in any outcome measure between groups. Secondary analyses showed that, among the subgroup of patients with severe baseline anxiety, those randomized to the CBT app had greater improvements on the HAM-A (Mean Difference = 7.44, standard error [SE] = 3.35, p = .037) and HADS-Anxiety Subscale (Mean Difference = 4.44, SE = 1.60, p = .010) compared with the control group.

Conclusion
Both the tailored CBT app for anxiety and the health education program were associated with improvements in anxiety, mood, and QOL, but these outcomes did not differ between study groups. The CBT app was more beneficial than health education for patients with severe baseline anxiety.
Yanıklı Hastalarda Erken Dönemde ve Negatif Basınçlı Yara Tedavi Sistemi Sonrası Cilt Grefti Operasyonlarında Greft Kayıplarındaki Etkinliğinin Karşılaştırılması
Authors: EMSEN İlteriş Murat 
Published: January 2019

Yanık, ilk
etapta vücut yüzey alanından temas ve hasar ile başlayıp, daha sonra maruz
kalınan süre ve şiddetine göre ağır hasarlara neden olan insan vücudunu
etkileyen hem fizyolojik hem de psikolojik bir süreçtir. Yanık ve tedavileri
üzerine çok sayıda çalışma bulunmaktadır.
2013-2018 yılları arasında hastanemiz yanık ünitesine baş vuran yanıklı
hastalar bu çalışmaya dahil edilmiştir. Erken dönemde yapılan cilt greftleri ve
Negatif Basınçlı Yara Tedavi sistemi sonrasında yapılan cilt grefti ameliyat
sonuçlarını karşılaştırdık. Sonuç olarak; hastaların hastanede kalış süreleri,
artan ek tedavi masrafları dikkate alındığında, bunlara ek olarak cilt greft
kayıpları da ilave olarak Yıkamalı Negatif Basınçlı Yara Tedavi protokolü alan
hastaların klasik yanık yara bakımı alan hastalara göre ciddi anlamda daha
etkin olduğunu gözlemledik.
Maternal outcome in term premature rupture of membranes
Authors: MN. Amulya , MS. Ashwini 
Published: January 2019

Background: Rupture of Fetal membranes before the onset of labour is called PROM. Premature rupture of membrane (PROM) is associated with various complications. The present study is undertaken to study the maternal morbidity in term PROM.Methods: A prospective cross-sectional study was conducted at Vijaynagar institute of medical science Ballari for a period of one year by Department of Obstetrics and Gynecology from November 2016 to October 2017. 120 cases of spontaneous rupture of membranes with term gestation with confirmed PROM were selected.Results: PROM was common in age group of 20-29 years (80%), and common in primigravida. Study showed majority of them belongs to low socioeconomic status (80%) , 13.33% belonged to middle socioeconomic status and 6.66% belonged to higher socioeconomic status. In present study, it is observed that 27.05% cases went into spontaneous labour and delivered normally, 56.50% cases delivered by induction and 20% cases were delivered by LSCS. The rate of maternal morbidity was 16.6%, which includes febrile morbidity accounting to maximum with 9.6% followed by wound infection 3.33% and others were PPH(1.66%)and puerperal sepsis (each 1.66%).Conclusions: The rate of maternal morbidity was 16.6% and no maternal death observed. Hence an appropriate and accurate diagnosis of PROM is essential for favorable outcome in pregnancy and reduces the maternal morbidity.
Use of non-pneumatic anti shock garment in hemorrhagic shock
Authors: Bangal Vidyadhar B. , Gavhane Satyajit , Raut Sonal , Thorat Ujwala 
Published: January 2019

Background: Non-pneumatic anti-shock garment (NASG) is a first-aid device that reverses hypovolemic shock and decreases obstetric haemorrhage. It consists of articulated neoprene segments that close tightly with Velcro, shunting blood from the lower body to the core organs, elevating blood pressure and increasing preload and cardiac output. The use of an NASG can stabilize a patient while awaiting transport, during transport, or during delays in receiving care at referral facilities.Methods: A prospective observational study of use of non-pneumatic anti shock garment (NASG) in cases with obstetric hemorrhagic shock was carried out at a tertiary referral center. As soon as severe shock was recognized in the hospital, the anti-shock garment was placed. Data on various parameters related to use of NASG was collected and interpreted to draw conclusions.Results: NASG was used in 25 cases of hemorrhagic shock during one-year period. Post-partum hemorrhage (36%) was the commonest indication for NASG use, followed by ruptured tubal ectopic pregnancy (28%). It was observed that 68% and 32 % of women had shock index of 1-1.5 and above 1.5 respectively at the time of application of NASG. The shock index rapidly improved to 0.5-0.9 in 92% and 1-1.5 in 8 percent of cases respectively after the application of NASG. The NASG was mainly used in labour room (40%) and emergency department (36%). NASG was applied by nurses and doctors together in 64% of cases. NASG was kept for a period 24 hours in 92% cases. The survival rate was 96% following use of NASG.Conclusions: NASG is a temporizing alternative measure in hemorrhagic shock management that shows a trend to reduce hemorrhage related deaths and severe morbidities. NASG should be made available at all health facilities that deal with high risk pregnancies and deliveries.
Predictive value of uterine artery: peak systolic velocity on the day of trigger for clinical pregnancy rate in infertile women
Authors: Makhija Karishma , Shrivasatava Deepti , Tiwari M. 
Published: January 2019

Background: The purpose of the study is to evaluate the role of uterine artery blood flow parameter measured by uterine artery two-dimensional (2D) power coloured doppler (PCD) ultrasound in predicting fertility outcomes in women undergoing ART treatment.Methods: It is prospective observational study. Total of 60 patients were included of receiving infertility treatment in the age group20-40 years. 20 patients were selected for timed intercourse , 20 patients were selected for intrauterine insemination , 20 patients were selected for invitro fertilization. Transvaginalsonography will be done on the day of trigger by BHCG , UA PSV were measured, and endometrial blood flow will be assessed. Predictivity of pregnancy rate will be looked after by 3 ways: BHCG values , UPT, Gestational sac on USG.Results: In TI/IUI/IVF cycles the Doppler parameter PSV of uterine artery (23.08+/-3.39 vs 20.37-/+5.43) in pregnant vs non-pregnant group did not differ significantly. The mean PSV of UA shows no significant difference women who were became pregnant during treatment and the women who were not became pregnant.Conclusions: With help of Doppler parameter imaging of women undergoing infertility it was found that UA PSV is non-significant to decide the prediction of pregnancy outcome.
Effect of vitamin C on testosterone level, sperm count and sperm morphology in gentamicin-induced Wistar rats
Authors: Rahayu Iis , Usman Elly , Reza Mohamad 
Published: January 2019

Background: Gentamicin is an aminoglycoside-class antibiotic that can lead to an increase in ROS and decrease antioxidant reserves that cause destruction of testicular cells that are known to inhibit cell division in testicular germ cells and protein synthesis in the testes as well as affect the production of testosterone that affects the quality of spermatogenesis. Vitamin C as an antioxidant can counteract ROS so that testicular cells can be repaired.Methods: This study was an experimental research with post tests only control group design on 25 male rats, 2-3 aged months, weight 160-240 g. Animals were divided into 5 groups. Negative control group was placed in cage without treatment, positive control given induced gentamicin 5mg/kgbb for the first 10 days, and 3 treatment given induced gentamicin 5mg/kgbb for the first 10 days and at days 11-51 were given vitamin C at a dose of 1.6mg; 2.25mg; 4.5mg. On 52 day, all of wistar rats perform terminated for analyzed the testosterone levels were by ELISA, sperm count was calculated with then haemocytometer observed with digital microscope, morphology of spermatozoa was analyzed by eosin staining and was observed with digital microscope.Results: Results of this study showed that the average of testosteron serum on control negatif group of 3,82ng/ml, control positif 3.73ng/ml, treatment 1 is 9.52ng/ml, treatment 2 is 8.29ng/ml, and traetment 3 is 2.28ng/ml. Sperm count on control negatif 41.68 million/ml, control positif 21.06million/ml, treatment 1 is 52.92 million/ml, treatment 2 is 57.12million/ml, treatment 3 is 80.88 million/ml and sperm morphology on control negative 74.00%, control positif 46.96%, treatment 1 is 58.82%, treatment 2 is 68.68%, and treatment 3 is 78.72%.Conclusions: It is concluded that vitamin C has significant effect on increasing testosteron level and sperm quality in gentamicin-induced wistar rats.
Membangun Karakter Peserta Didik MI/SD Melalui Media Komik Pembelajaran
Authors: Laksana Sigit Dwi 
Published: January 2019

Problems of students’ character are currently the main focus in the education realm. The role of the family, teachers, and the society is critical in shaping the character of children.The weakness of character-based learning in an educational institution has been the key factor on the problem of student characters. The teacher in the learning process is often lessinovative and creative in designing the learning process, especially in terms of learning media design. Comic is one of media that can help students and can replace the position of teachers in learning activities both inside and outside the classroom. Comic can be used in a two-way learning process, namely as a teaching tool and as a medium for shaping the character of the students. Based on observation field, it is known that in the process of learning, comic as instructional medium has never been utilized. Therefore, the presence of learning media in the form of comics is expected to assist the teacher in the learning process and helps in forming the character of students. Comic languages using polite language are expected to avoid impolite languages and not in accordance with the objectives of education character. This also inspires the use of instructional media comic contents of learning materials in elementary school. Comics as a medium of learning is able to build the foundations of character for learners and are ultimately capable of constructing human characters that are intact and resilient.
Implementasi Metode Mind Mapping untuk Meningkatkan Kemampuan Menulis Cerita Pada Siswa Kelas IV SDN Sumurgung
Authors: Widawarti Enik 
Published: January 2019

Kemampuan dapat diidentifikasi sebagai kesanggupan, kecakapan, kekuatan, atau potensi diri sendiri. Kemampuan awal siswa merupakan prasarat yang diperlukan dalam mengikuti proses belajar mengajar selanjutnya. Proses pembelajaran dan pengambangan kemampuan awal siswa dapat menjadi titik tolak untuk membekali siswa agar dapat mengembangkan kemampuan baru. Sedangkan menulis cerita merupakan kegiatan menyampaikan pesan melalui media tulisan beserta tanda bacanya atau kegiatan merubah bunyi yang dapat di dengar menjadi kata-kata yang dapat dilihat. . Tujuan dari penelitian ini adalah untuk meningkatkan kemampuan menulis cerita melalui penggunaan metode peta pikiran Mind Mapping pada siswa kelas IV SDN Sumurgung tahun pelajaran 2008/2009. Variabel yang menjadi sasaran perubahan dalam penelitian tindakan kelas ini adalah kemampuan menulis cerita, sedangkan variabel tindakan yang digunakan dalam penelitian ini adalah metode peta pikiran Mind Mapping. Penelitian ini menggunakan penelitian tindakan (action research) sebanyak tiga putaran. Setiap putaran terdiri dari empat tahap yaitu: rancangan, kegiatan dan pengamatan, refleksi, dan refisi. Sasaran penelitian ini adalah siswa kelas IV SDN Sumurgung tahun pelajaran 2008/2009. Data yang diperoleh berupa hasil tes formatif, lembar observasi kegiatan belajar mengajar. Dari hasil analis didapatkan bahwa prestasi belajar siswa mengalami peningkatan dari siklus I sampai siklus III yaitu, siklus I (65,22%), siklus II (73,91%), siklus III (91,30%) dengan nilai rata-rata siklus I (63,87), siklus II (74,35), dan siklus III (80,43). Kesimpulan dari penelitian ini adalah metode Mind Mapping dapat berpengaruh positif terhadap kemampuan menulis cerita siswa kelas IV SDN Sumurgung tahun pelajaran 2008/2009, serta model pembelajaran ini dapat digunakan sebagai salah satu alternatif pembelajaran Bahasa Indonesia.
Tindak Pidana Kelalaian Menyebabkan Luka yang Dilakukan oleh Dokter Gigi: Analisis Putusan Nomor: 257/Pid.B/2015/PN.Dps
Authors: Qomariyah Selly Ismi , Ohoiwutun Y.A Triana , Prihatmini Sapti 
Published: January 2019

There is a substantial difference between the ordinary crime related to its results and that related to its causes. In order to classified as a crime, the negligence carried out by medical personnel needs to be previously described regarding the fulfillment of the elements of lawlessness. This paper analyzes whether there is medical malpractice and with the following lawlessness in the court decision number 257/Pid.B/2015/PN.Dps. Throughout the analysis, it will provide a comprehension to the qualification of whether malpractice, medical negligence or medical risk. The result of the study finds that such a crime can be qualified to medical malpractice, even though he did not fulfill the nature against formal law but it meets the element of nature against material law.
Keywords: Medical Malpractice, Lawlessness, Crime
Peran Dewan Kehormatan Penyelenggara Pemilu dalam Menjaga Kemandirian dan Integritas Pemilihan Umum di Indonesia
Authors: Puspitasari Dyan 
Published: January 2019

Nowadays, Indonesia remains challenged to the barrier in means of transportation, especially in small areas in which it makes arduous the Election Organizers Honorary Council (DKPP) to carry out its duties. Based on Article 25 of DKPP Regulation Number 2 of 2012, one of the facilities provided to DKPP is the implementation of a long-distance trial by video conference. There are a number of challenges faced by DKPP, including the relatively new age so that people do not really know this institution. In addition, the DKPP institution is quite limited to being located only in the capital, while the task of the institution encompasses national jurisdiction. The geographical condition of Indonesia is broad and consists of many areas also make the response to ethics code violations less efficient along with issues of compliance with DKPP decisions. Thus, the role of the DKPP is needed in maintaining the independence and integrity of the organizers of the General Elections (Elections) and ways to strengthen the role of the DKPP in maintaining the independence and integrity of election administration in Indonesia.
Keywords: Election Law, Electoral Institution, Independence