bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel semi‐analytical method for mutual inductance calculation of the thin spiral disk coils
Authors: Yıldırız Emin , Kemer Salih Burak 
Published: June 2019

Accurate and fast calculation of the self and mutual inductance of coils is an important factor in system design and optimization for many applications. The methods of calculation mutual inductance between two spiral disk coils include elliptic integral solutions and coefficients in literature. In this study, a new semi‐analytical method is proposed to calculate the mutual inductance between two thin disk coils without any coefficient and complex integral solutions. For this purpose, the circular winding is treated as polygonal winding with multiple edges. Unlike Grover's average diameter approach, the gaps between the turns of the coils and the diameter of the wire are included in the calculation. To observe the reliability of the method developed here, the mutual inductance between identical disk coils with an inner diameter of 10 and 20 cm were calculated using both methods. To confirm the accuracy of the proposed method, the experimental results are compared with two methods using the same coils. It is observed that the new method gives acceptable results (maximum error of 2.83%) especially at the distances equals to the inner radius. Consequently; this method is useful for the design of loosely coupled systems, such as wireless power transfer and pressure sensors.
GIADA microbalance measurements on board Rosetta: submicrometer- to micrometer-sized dust particle flux in the coma of comet 67P/Churyumov-Gerasimenko
Authors: Della Corte V. , Rotundi A. , Zakharov V. , Ivanovski S. , Palumbo P. , Fulle M. , Longobardo A. , Dionnet Z. , Liuzzi V. , Salatti M. 
Published: June 2019

Context. From August 2014 to September 2016, Rosetta escorted comet 67P/Churyumov-Gerasimenko (67P) during its journey around the Sun. One of the aims of Rosetta was to characterize cometary activity and the consequent formation of dust flux structures in cometary comae.
Aims. We characterize and quantify the submicrometer- to micrometer-sized dust flux that may be shaped in privileged directions within the coma of 67P inbound to and outbound from perihelion.
Methods. The in situ dust-measuring instrument GIADA, part of the Rosetta/ESA payload, consisted of three subsystems, one of which was the Micro Balance Subsystem (MBS), composed of five quartz crystal microbalances. From May 2014 to September 2016, MBS measured the submicrometer- to micrometer-sized deposited dust mass every 5 min.
Results. We characterized the submicrometer- to micrometer-sized dust mass flux in the coma of 67P. The anti-sunward and the radial direction are preferred, and the flux is higher in the anti-sunward direction. The measured cumulative dust mass in the anti-sunward direction is 2.38 ± 0.04 × 10−7 kg, and in the radial direction, it is 1.18 ± 0.02 × 10−7 kg. We explain the anti-sunward dust flux as the effect of nonuniform gas emission between the night- and dayside of the nucleus, which acts in combination with the solar radiation pressure. We compared the cumulated dust mass of particles ≤5 μm with particles ≥100 μm. The retrieved ratio of ≈2% implies a differential size distribution index of ≈−3.0, which confirms that particles of size ≥0.1 mm dominate the dust coma cross-section of 67P during the entire orbit.
Conclusions. Submicrometer- to micrometer-sized dust mass flux measurements were made for the first time from the arising of cometary activity until its extinction. They indicate that these particles do not provide a substantial optical scattering in the coma of 67P with respect to the scattering caused by millimeter-sized particles. In addition, MBS data reveal that the measured dust flux is highly anisotropic: anti-sunward plus radial.
Ernährungstherapie des Intensivpatienten
Authors: Koch Alexander , Bündgens Lukas , Tacke Frank 
Published: June 2019

AbstractNutritional therapy is an elemental component of intensive care treatment. Therapeutic goals are the enteral or parenteral provision of calories, protein, electrolytes, vitamins and trace elements. Pathophysiologically, metabolism in critical illness is characterized by a catabolic stress status. This results from an underlying systemic inflammatory response and is associated with increased rate of infections, multiple organ failure and unfavourable outcome. In this article, the principles and strategies of nutrition support therapy in critically ill patients are presented, based on current guidelines.
Bewusstseinsstörungen und Koma
Authors: Erbguth Frank 
Published: June 2019

AbstractCerebral diseases such as epileptic seizures, cerebral hemorrhages or meningoencephalitis are the primary cause of approximately 50 % of non-traumatic acute disorders of consciousness. For the differential diagnosis, history and other symptoms are important such as hemiplegia, signs of brain stem dysfunction, meningism or headache. Metabolic, endocrinologic, toxicologic or electrolytic causes of coma usually can be diagnosed by laboratory examinations. Anamnestic informations, body inspection, clinical neurological examination as well as laboratory and imaging findings have to be added and categorized by a multilevel composition to establish a conclusive diagnosis. Simultaneously therapeutic measures for suspected primary cerebral diseases must be initiated, for example a rapid antibiotic treatment in case of a possible bacterial meningitis. A fast and structured diagnostic approach is crucial for ensuring a good prognosis and helps to miss relevant diagnostic steps. Potential diagnostic and therapeutic pitfalls must be kept in mind.
Das kardiorenale Syndrom
Authors: Scurt Florian Gunnar , Kuczera Tim , Mertens Peter René , Chatzikyrkou Christos 
Published: June 2019

AbstractChronic heart failure is associated with high morbidity and mortality and is the most common hospital diagnosis for elderly patients. Concomitant or superimposed acute or chronic kidney injury, as is the case with cardiorenal syndrome, has a dramatic impact on the outcome. The inhibition of the neurohumoral axis and the adequate treatment of hypervolemia are fundamental elements of modern cardiac insufficiency therapies. In addition to optimal conservative therapy, there are other options: VAD implantation, hemodialysis and peritoneal dialysis. The PD offers biological and clinical benefits as an additive therapy for the treatment of patients with heart failure, refractory hypervolemia and non-urinary renal failure.
Application of Carbon Nanotubes in Breast Cancer Therapy
Authors: Tajabadi Mahdis 
Published: June 2019

AbstractConjugated single-walled carbon nanotubes (SWNT) have been shown to be promising in cancer-targeted accumulation and is biocompatible, easily excreted, and possesses little toxicity. The present study aims at reviewing the recent advancements in carbon nanotubes especially SWNT for improving the treatment of breast cancer. Nanotube drug delivery system is a potential high efficacy therapy with minimum side effects for future tumor therapy with low doses of drug.
Radio- und Photosensitivierung von Plasmid-DNA durch den
DNA-bindenden Liganden Propidiumiodid: Untersuchungen zur
Auger-Elektronen-Induktion und zum Nachweis von
Cherenkov-Strahlung
Authors: Kotzerke Jörg , Runge Roswitha , Götze Pauline , Wunderlich Gerd , Enghardt Wolfgang , Freudenberg Robert 
Published: June 2019

Zusammenfassung
Ziel Untersucht wurde, ob Propidiumiodid (PI) die DNA-schädigende Wirkung
von ionisierender und nicht ionisierender Strahlung (Röntgenstrahlung, Alpha-,
Beta-, Auger-Elektronen-Strahlung bzw. Licht diverser Wellenlängen) verstärken
kann. Diese biophysikalische Versuchsanordnung ermöglicht es zu überprüfen, ob
Cherenkov-Strahlung in relevantem Umfang via photodynamischer Effekte und
erhöhter DNA-Schädigung nachweisbar ist.
Material und Methoden Konformationsänderungen der Plasmid-DNA durch
DNA-Schäden wurden mittels Gelelektrophorese und Fluoreszenzfärbung detektiert
und quantifiziert. Wasserstoffperoxid, Zinndichlorid und Dimethylsulfoxid wurden
als chemische Modulatoren, Tc-99m, Re-188, Ra-223 und Röntgenstrahlung (32 kV
und 200 kV) zur Bestimmung der Radiotoxizität und Licht (λ = 254 nm, 366 nm und
530–575 nm) zur Bestimmung der Phototoxizität eingesetzt.
Ergebnisse Die Radiotracer und die Röntgenstrahlung verursachten
dosisabhängige DNA-Schäden. PI fungierte nicht als Radio-Sensitizer bei den
Radionukliden und nur in geringem Maß bei Röntgenstrahlung. Die Phototoxizität
war abhängig von der Wellenlänge. Licht im Wellenlängenbereich von 530–575 nm
(VIS) resultierte in Kombination mit PI in direkten DNA-Schäden. Die Ausbeuten
der Cherenkov-Strahlung lagen weit unter der Photonen-Emission der
Lichtbestrahlung und konnten daher von der Radiotoxizität nicht unterschieden
werden.
Schlussfolgerung PI bindet an Plasmid-DNA, ist nicht chemotoxisch und
steigert kaum die Radiotoxizität. Die Phototoxizität und die Wirkung von PI sind
abhängig von der Wellenlänge. Keine Art der Energiezufuhr konnte via PI eine
Auger-Elektronen-Kaskade induzieren. Auch eine erhöhte DNA-Schädigung durch
photodynamische Effekte via Cherenkov-Strahlung war nicht nachweisbar.
Cytotoxic Cardenolides from the Leaves of Acokanthera oblongifolia
Authors: Pecio Łukasz , Hassan Emad M. , Omer Elsayed A. , Gajek Gabriela , Kontek Renata , Sobieraj Andrzej , Stochmal Anna , Oleszek Wiesław 
Published: June 2019

AbstractThree previously undescribed cardenolides, acovenosigenin A 3-O-α-L-acofriopyranoside (1), 14-anhydroacovenosigenin A 3-O-[β-D-glucopyranosyl-(1″→4′)-O-α-L-acofriopyranoside] (2), and 14-anhydroacovenosigenin A 3-O-[β-D-glucopyranosyl-(1″→4′)-O-α-L-acovenopyranoside] (3), together with the two already known ones, 14-anhydrodigitoxigenin 3-O-β-D-glucopyranoside (4) and acospectoside A (5), were isolated from the leaves of Acokanthera oblongifolia. The influence of cardenolides 1 – 3 and acovenoside A (found in the Acokanthera genus) on three cancer cell lines (HT29, HCT116, and AGS) was also investigated. The most promising results, in comparison with oxaliplatin, were obtained for compound 1, which was found to be highly cytotoxic for all tested cell lines, HT29 (IC50 = 63.49 nM), HCT116 (IC50 = 67.35 nM), and AGS (IC50 = 80.92 nM). Unfortunately, 1 also showed similar toxicity towards normal lymphocytes (IC50 = 98.03 nM).
Certified Diabetes Educator: An Important Aid in Improving Patient Care in Diabetes
Authors: Joshi Ameya , Shaikh R. D. Sana N. 
Published: June 2019

AbstractDiabetes mellitus is a chronic disease in which education plays a vital part. However, in India that is overburdened with diabetes has short of diabetes educators. Care for diabetes is limited by the adverse physician-to-patient ratio and lack of trained paramedical personnel. The following review focuses on role of diabetes educators in diabetes care and their current status in India.
Osseous Sarcoidosis with a Solitary Lytic Skull Lesion: A Case Report
Authors: Thirunavukarasu Vignaraja , Thirunavukarasu Caitlin , Willis Timothy , Tsahtsarlis Antonio 
Published: June 2019

AbstractBone sarcoidosis is an uncommon manifestation of the multisystemic disease with skull involvement being rare. We present the case of a 32-year-old female who was referred by her General Practitioner with a left calvarial lesion on a background of previous unilateral 7th nerve palsy and diabetes mellitus. Images demonstrated a left frontoparietal calvarial osteolytic lesion. She underwent resection by the neurosurgical team with histopathological study revealing noncaseating granulomas, consistent with sarcoidosis. Given absence of other systemic features of sarcoidosis, she did not undergo systemic treatment.
HAEMOcare: The First International Epidemiological Study Measuring Burden of Hemophilia in Developing Countries
Authors: Gupta Naresh , Benbouzid Abderrahmane , Belhani Meriem , El Andaloussi Mohammed , Maani Khadija , Wali Yasser , Benchikh El Fegoun Soraya , Saad Hossam Ali , Mahlangu Johnny 
Published: June 2019

Introduction Optimizing hemophilia care remains challenging in developing countries. Burden-of-disease studies are important to develop strategies for improving hemophilia care.
Aim The HAEMOcare study evaluated the factors contributing to hemophilia-related orthopedic disease burden in developing countries.
Methods HAEMOcare was a noninterventional, cross-sectional, epidemiological study conducted in Algeria, India, Morocco, Oman, and South Africa. Male patients with severe hemophilia (N = 282) aged ≥6 years, without or with inhibitors, being treated on-demand for bleeding were included. Hemophilia-related orthopedic clinical and functional status was assessed using the Hemophilia Joint Health Score (HJHS), radiological status with the Pettersson Score, and quality of life with the EuroQol five-dimension questionnaire (EQ-5D-3L). Direct and indirect economic costs of hemophilia care were also calculated.
Results Patients (mean [standard deviation, SD] age: 20.8 [10.6] years) experienced a mean annualized bleeding rate of 25.8. Overall mean (SD) HJHS and Pettersson score were 17.9 (12.8) and 15.0 (13.5), respectively; scores were similar between patients without or with inhibitors (p = 0.21 and 0.76, respectively). Approximately 70% of adults reported problems relating to pain/discomfort and mobility parameters in the EQ-5D-3L. Mean distance to a hemophilia treatment center (HTC) was 79.4 km. As expected, total costs of hemophilia were statistically significantly higher in patients with inhibitors versus without inhibitors (p = 0.002).
Conclusion Inadequate access to HTCs and expert care, along with high bleeding rates, led to equivalent hemophilia-related orthopedic morbidity between hemophilia patients without and with inhibitors. HAEMOcare documented the economic and disease burdens associated with suboptimal hemophilia care in developing countries.
Pelvic Actinomycosis Mimicking Pelvic Malignancy
Authors: Saramago Sofia Modesto , Cominho Joana Catarina , Proença Sara Soares Marques , Conde Pedro João Casado , Nunes Filomena Maria Pinheiro 
Published: June 2019

AbstractAsymptomatic female genital tract colonization with Actinomyces spp is not uncommon, particularly among intrauterine device users. Pelvic actinomycosis is an extremely rare disease. The clinical picture can resemble an advanced ovarian malignancy. We report a case of pelvic actinomycosis mimicking ovarian malignancy diagnosed postoperatively. Preoperative diagnosis is possible if there is a high index of suspicion, obviating extensive surgery and preserving fertility, since long term antibiotic treatment can be completely effective. Pelvic actinomycosis should be included in the differential diagnosis of women presenting a pelvic mass, especially if there is intrauterine device use history.
Pregnancy Among Women with Kidney Transplantation: A 20-Years Single-Center Registry
Authors: Mariano Stephanye , Guida Jose Paulo de Siqueira , Sousa Marcos Vinicius de , Parpinelli Mary Angela , Surita Fernanda Garanhani , Mazzali Marilda , Costa Maria Laura 
Published: June 2019

Objective To assess maternal and perinatal outcomes in pregnancies after kidney transplantation in a tertiary center in Brazil.
Methods Retrospective cohort of pregnancies in women with kidney transplantation at the Universidade Estadual de Campinas, from January 1995 until December 2017. Medical charts were reviewed, and maternal and perinatal outcomes were described as means and frequencies. Renal function and blood pressure were evaluated during pregnancy and postpartum.
Results A total of 22 women had at least 1 pregnancy during the considered time interval, and 3 of them had > 1 pregnancy, totalizing 25 pregnancies. The mean age at transplantation was of 24.6 ± 4.2 years old, and the mean time interval until pregnancy was of 67.8 ± 46.3 months. The most frequent complication during pregnancy was hypertension, which affected 11 (64.7%) women. The gestational age at delivery was 34.7 ± 4 weeks, and 47% of these pregnancies were preterm (< 37 weeks). A total of 88.2% of the women delivered by cesarean section. Renal function, measured by serum creatinine, remained stable during pregnancy, and the systolic blood pressure increased significantly, while the diastolic blood pressure did not differ during pregnancy.
Conclusion Pregnancy after kidney transplantation is a rare event. Pre-eclampsia and prematurity were frequent complications, and cesarean section rates were very high. A specialized antenatal and postpartum care with a multiprofessional approach and continuous monitoring of graft function are essential for the early diagnosis of complications and improved outcomes.
Morphological and Clinical Significance of Thebesian Valve Guarding Ostium of Coronary Sinus
Authors: Kulkarni Veena , Kulkarni Vijay K. ,   Vagdevi H.S.,   Vasanth Kumar H.S.
Published: June 2019

Abstract
Background The advent of novel therapeutic techniques require cannulation of coronary sinus. The Thebesian valve guarding the ostium of coronary sinus can pose practical difficulties during such procedures.
Aim With this background we undertook a detailed study of the morphological features of Thebesian valve, so that we can substantially evaluate the clinicoanatomical importance of it.
Materials and Methods Fifty human dissected cadaveric heart specimens were selected from the department of anatomy, SDM College of Medical Sciences and Hospital, Dharwad. The location of ostium of coronary sinus and the occurrence of the Thebesian valve and its shape, composition, and extent of occlusion of the ostium were carefully observed and noted.
Results Our observations revealed that 90% of specimens had the Thebesian valve guarding the opening of coronary sinus. It was semilunar in shape in 74% of specimens. The valve was membranous in composition in 46% of specimens. Among these, in 26% of specimens the valve almost covered more than 50% of the ostium of coronary sinus indicating moderate to severe occlusion.
Surgical Treatment of Tracheal Lipoma after Multiple Bronchoscopy Interventions and Placements of a Tracheal Stent
Authors: Zhang Xiaoming , Ji Tao , Yang Longhai , Liu Yi , Lin Hongsheng , Pan Huiyu , Zhou Zizi 
Published: June 2019

Background The majority of adult primary tracheal tumors are malignant; however, as one type of benign tumors, lipoma is extremely uncommon.
Case Description We report a case where lipoma was first misdiagnosed as bronchial asthma, followed by sudden aggravation of dyspnea after trauma, and computed tomography (CT) examination of the neck and chest confirmed a tracheal tumor. Through multiple bronchoscopy interventions and placements of a tracheal stent, little therapeutic benefit was discovered, and resection of the tracheal tumor combined with tracheal end-to-end anastomosis was performed to ultimately achieve a cure.
Conclusion Primary tracheal tumors should be highly suspected in patients with recurrent and gradually worsening dyspnea; timely cervical, thoracic CT and bronchoscopy can provide an accurate diagnosis. Surgical radical resection is the only way to cure all benign tracheal tumors such as lipoma.
Current Controversies in Large-Vessel Inflammatory Vasculitis and Thoracic Aortic Aneurysm Disease
Authors: Harky Amer , Fok Matthew , Howard Callum , Bashir Mohamad 
Published: June 2019

AbstractLarge-vessel vasculitis encompasses the spectrum of vasculitides, which pathologically cause chronic granulomatous inflammatory changes, primarily in the aorta and its major branches. These patients are at risk of developing life-threatening aortic lesions that, without recognition and prompt treatment, can cause detrimental effects. Many provocative issues surrounding large-vessel vasculitis and its surgical treatment still remain, spanning from recognition to management. In this review, we discuss the main large-vessel vasculitides, Takayasu's arteritis and giant cell arteritis. We include the key points and current controversies surrounding diagnostic imaging, timing of interventions, and patient outcomes.
Pulmonary Arterial Hypertension and Therapeutic Interventions
Authors: Ishak Gabra Nader B. , Mahmoud Omar , Ishikawa Oki , Shah Varun , Altshul Erica , Oron Maly , Mina Bushra 
Published: June 2019

AbstractPulmonary hypertension is an uncommon disease that carries a significant morbidity and mortality. Pulmonary arterial hypertension is a subtype of pulmonary hypertension that describes a group of disease entities that lead to an elevation in precapillary pulmonary artery pressure. Despite advances in the diagnosis and treatment of pulmonary arterial hypertension, it remains a difficult disease to recognize and manage. In this review article, we will discuss the definition and diagnosis of pulmonary arterial hypertension. Additionally, we will discuss the ever-expanding management options, their mechanisms and strategies, including combination therapy and the most recent advances and future directions.
Orthopaedic Surgeons and Smartphones
Authors: Ahmed Ahmed M. , Khalifa Ahmed A. 
Published: June 2019

AbstractPhone technology has witnessed revolutionary advancement in the form of smartphones. Health care professionals, especially orthopaedic surgeons, have been able to make the best use of such remarkable devices. Surveys conducted over years in many different countries have shown how often orthopaedic personnel use smartphone apps for both work and education. Moreover, phone companies have provided surgeons with many useful apps that can be used in the operating theater and emergency room as well. However, there are some concerns regarding the validity of information available in the applications.
Flavone of Hippophae (H-flavone) lowers atherosclerotic risk factors via upregulation of the adipokine C1q/tumor necrosis factor-related protein 6 (CTRP6) in macrophages
Authors: Zhuo Xiaozhen , Tian Yuling , Wei Yadong , Deng Yangyang , Wu Yan , Chen Tao 
Published: June 2019

ABSTRACT
In this study, we examined the mechanism of Flavone of Hippophae (H-flavone) in regulating macrophage foaming and atherosclerosis (AS) plaque formation. H-flavone treatment increased the secretion of C1q/tumor necrosis factor-related proteins 6 (CTRP6) in Ox-LDL-treated mouse peripheral blood macrophage cells (PBMC) and significantly reduced the percentage of cholesteryl ester (CE) in PBMC. Additionally, H-flavone suppressed Ox-LDL-induced cell foaming and the production of inflammatory cytokines through upregulating CTPR6 expression. Next, we further validated the inhibitory effect of H-flavone on plaque formation and inflammation in a mouse AS model. A substantial reduction in the secretion of inflammatory cytokines was observed in apoE-/- mice by H-flavone. Immunohistochemistry and Oil Red O staining results showed that H-flavone suppressed macrophage infiltration and the development of AS plaque. These effects were more pronounced in early administration. Our results suggest that H-flavone effectively inhibits macrophage foaming, inflammation and vascular plaque formation by upregulating CTRP6 and may be used to reduce AS risk.