bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interpreting Patient-reported Outcome Scores for Clinical Research and Practice
Authors: Shi Qiuling , Mendoza Tito R. , Cleeland Charles S. 
Published: April 2019

Objectives:
Cutpoints are specific numeric values used to create discrete categories for patient-reported outcome (PRO) items or scales. Cutpoints are widely used in both clinical research and practice. This article offers a definition for cutpoints, describes strategies for determining actionable cutpoints, and discusses considerations related to interpreting cutpoints in clinical applications.

Methods:
We clarify the definition of cutpoints for PRO measures and summarize the major statistical approaches for identifying cutpoints, including multivariate analysis of variance and receiver operating characteristic and regression modeling.

Discussion:
We review issues related to cutpoint determination and interpretation that should be considered when integrating PROs into clinical research and practice, including the selection of anchors, variability of cutpoints, and clinical burden that may be generated when a cutpoint is used as a threshold for further clinical action.

Key Points:
Cutpoints are widely used to categorize PRO responses in both clinical research and practice. Cutpoints can be derived for PRO measures regardless of the response scale used; however, the mild, moderate, and severe categories generated from numeric cutpoints are distinct from the mild, moderate, and severe categories found in some PRO measures that use verbal descriptors as response options. Bootstrap analysis is recommended to quantify the variability of cutpoints. The application of cutpoints is limited by how well the anchors are chosen and how cutpoints developed using group-level data are applied at the individual level.
Engaging Patients and Clinicians in Online Reporting of Adverse Effects During Chemotherapy for Cancer
Authors: Absolom Kate , Gibson Andrea , Velikova Galina 
Published: April 2019

Introduction:
During cancer treatment the timely detection and management of adverse events is essential for patient safety and maintaining the quality of life. Electronic patient self-Reporting of Adverse events: Patient Information and aDvice (eRAPID) was devised to support oncology practice, by allowing patients to self-report symptoms online at home during and beyond cancer treatment. Fundamentally the eRAPID intervention delivers immediate severity-tailored feedback directly to patients to guide self-management strategies or hospital contact. Patient data are available in electronic health records for hospital staff to access and review as part of clinical assessments.

Methods for Interpreting and Addressing Patient-Reported Outcome (PRO) Scores:
The eRAPID intervention has 5 main interconnecting components (clinical integration into standard care pathways, patient symptom reports, self-management advice, information technology, and staff/patient training). Following guidance for the development of complex interventions and using a mixed methods approach, eRAPID was created through a number of stages and tested in a series of usability settings before undergoing systematic evaluation in a randomized controlled trial. These developmental stages are described here with a focus on how decisions were made to enhance patient and professional engagement with symptom reports and encourage interpretation and clinical utilization of the data.

Discussion:
Clinically embedded PRO interventions involve a number of elements and stakeholders with different requirements. Following extensive developmental work eRAPID was pragmatically designed to fit into current oncology practices for reviewing and managing chemotherapy-related toxicities.
A Case Management System for Integrating Patient-reported Outcome Assessment in Clinical Practice
Authors: Zahrieh David , Alexander Alex , Fruth Briant , Tan Angelina D. , Le-Rademacher Jennifer , Warsame Rahma , Croghan Katrina , Sloan Jeff A. 
Published: April 2019

Introduction:
What if you could only ask one question of the patient during a clinic visit? Further, suppose the patient’s biggest concern can pragmatically be incorporated into routine clinical care and clinical pathways that can address the patient’s single biggest concern can be identified. If the principal concern can be dealt with efficiently at each visit through key stakeholder case management, positive outcomes should result. Therefore, motivated by the need for patient-centered health care visits, the Beacon electronic patient-reported outcomes (PRO) quality of life (QOL) tool was developed.

Methods:
Central to the tool is that at each health care visit, the patient’s biggest concern is electronically communicated to the health care team. Therefore, the tool can help catalyze important discussions between the health care team and the patient, perhaps on topics that would not have been discussed otherwise at a routine visit. In recognition of the community of resources needed to provide comprehensive care, the tool generates clinical pathways or actions that can be pursued to address the patient’s biggest concern. The concern is efficiently triaged such that members of the health care community with appropriate expertise and resources are identified to address and manage that single biggest concern signaled by the patient. A report, which can be uploaded into the patient’s medical chart, is created and provides a list of resources for a case manager to assist the patient and contains graphical presentations of the patient’s QOL and a history of prior concerns. The report also labels potentially significant changes in QOL.

Discussion:
The tool, which has been applied successfully in several health conditions, acts as a beacon to health care providers so that a patient’s self-reported concern can be consistently and effectively integrated into their care.

Key Points:
It is impractical to try to deal with every patient concern in every visit. The key to the Beacon tool is that at each visit the patient’s biggest concern is identified, clinical pathways indicated, and resources efficiently matched to address the patient’s biggest concern.
A Rasch Measurement Theory Approach to Improve the Interpretation of Patient-reported Outcomes
Authors: Browne John P. , Cano Stefan J. 
Published: April 2019

Introduction:
Interpretability is a key challenge for researchers, clinicians, and patients interested in using the output of patient-reported outcome (PRO) instruments. When rich and detailed meaning is required to assist individual patients to make treatment choices we propose that the item content of psychometric rating scales should be better leveraged to improve interpretability.

Methods:
Modern psychometric methods such as Rasch measurement theory allow PRO users to map patient progress up or down a scale over time to item benchmarks. These benchmarks represent the relative difficulty associated with each item contained in a scale. The most difficult items benchmark the best overall outcome on a scale and the least difficult items represent the worst overall outcome. The group-level effects of different treatment options can also be mapped to item benchmarks and compared with those of individual patients.

Discussion:
The proposed method leverages the content already available in PRO instruments to improve interpretation. This approach locates both individuals (in this instance breast cancer patients undergoing surgery) and treatments (in this instance breast reconstruction techniques), on a hierarchy of health variables where each variable represents a progressively more advanced step in the recovery process. The approach can specify the aspects of a health concept where patients are currently competent, and the aspects which they might gain from a new treatment. It can also assist attempts by industry to communicate specific treatment benefits to their target audience.

Key Points:
The method is best applied when patients need guidance about the likely benefits of different treatment options, when a PRO instrument has been developed using a modern psychometric method such as Rasch measurement theory, when there is good evidence from well-conducted studies of the group-level benefits of different treatment options, and these benefits have been measured using appropriate PROs. The method depends on good “fit” of individual patient responses to an underlying model. However, even when fit is poor it may be useful for patients to understand the “ladder” of health achievements for their condition (from the perspective of the average patient) and where different treatment options sit on this ladder.
The Association Between Symptoms of Anxiety, Depression, and Cardiovascular Risk Factors
Authors: Rioli Giulia , Tassi Silvia , Mattei Giorgio , Ferrari Silvia , Galeazzi Gian Maria , Mancini Stefano , Alboni Silvia , Roncucci Luca 
Published: April 2019

Abstract
Cardiovascular diseases, anxiety, and depression are among the most frequent clinical conditions in the Western world, often in comorbidity. Evidence regarding a shared pathophysiology suggests a mediating role by chronic systemic inflammation. The aims of this study were to measure the association between anxiety and depressive symptoms, cardiovascular risk factors, and inflammatory markers. Outpatients aged 40 years or more undergoing colonoscopy after positive fecal occult blood test were enrolled; the following data were collected: body mass index, blood pressure, blood glucose, lipid profile, C-reactive protein (CRP) level, carotid thickness, Hospital Anxiety and Depression Scale, Temperament and Character Inventory, INTERdisciplinary MEDicine Self-Assessment, and 36-Item Short-Form Health Survey scores. Fifty-four patients were enrolled; 30.2% had anxiety symptoms, 18.9% depressive symptoms, and 9.4% concomitant anxiety-depressive symptoms. Anxiety symptoms were associated with low high-density lipoprotein levels. Depressive symptoms were associated with CRP levels, providing supporting evidence for the role of inflammation in the pathophysiology of depression.
Relationship of Suicidal Ideation With Demoralization, Depression, and Anxiety
Authors: Xu Ke , Hu Deying , Liu Yilan , Han Yanhong , Guo Xin , Teng Fen , Zhou Yi 
Published: April 2019

Abstract
Demoralization is a form of psychological distress that may cause suicidal ideation. Demoralization syndrome is common among cancer patients, but there has been little empirical study on the association of suicidal ideation with demoralization, depression, and anxiety in this population. This study aims to investigate the prevalence of high demoralization among cancer patients in mainland China and the contribution of high demoralization to suicidal ideation beyond the impact of self-report depression and anxiety. In this cross-sectional study, 303 patients with cancer were invited to complete questionnaires. In total, 14.5% participants reported suicidal ideation and 49.50% high demoralization. Logistic regression analysis identified high demoralization as an independent risk factor for suicidal ideation. Only depression (odds ratio [OR], 6.68) had a stronger influence on suicidal ideation than demoralization (OR, 5.85), and patients with both depression and high demoralization were most likely to experience suicidal ideation. These findings suggest that measures of demoralization can help identify cancer patients at high suicide risk and that such patients require further attention and measures targeting demoralization for suicide prevention.
Methadone-Related Delirium
Authors: Westermeyer Joseph , Thuras Paul , Yoon Gihyun , Kolla Bhanu Prakash , Batres-y-Carr Tegan , Dimitropoulos Erica 
Published: April 2019

Abstract
Goals consist of determining 5-year prevalence and recurrence of methadone-related delirium (MRD), along with causes, treatments, and outcomes. Sample comprised 81 patients in methadone maintenance treatment. Criteria for MRD encompassed delirium with high methadone serum levels plus alleviation of delirium upon lowering methadone serum levels. MRD occurred in 14 cases who had 25 episodes. MRD precipitants included physician prescribing (i.e., excessive methadone or medications slowing methadone metabolism), drug misuse, and renal-fluid alterations. Social affiliation (housing with family, intimate partner) reduced MRD; employment increased MRD. Recovery occurred in 23/25 episodes of MRD; two episodes progressed to dementia. Obtaining serum methadone levels fostered prompt recognition.
An Examination of the Association Between Emotion Reactivity and Distress Tolerance Among College Students
Authors: Bruns Kaitlyn M. , O'Bryan Emily M. , McLeish Alison C. 
Published: April 2019

Abstract
The goal of the present investigation was to examine associations between emotion reactivity in global and specific distress tolerance domains. Participants were 113 undergraduates (65.5% female, 82.3% Caucasian; M
age = 20.0, SD = 4.02, range = 18–45 years) who completed a battery of self-report measures. As hypothesized, the results indicate that, after controlling for sex and negative affectivity, greater levels of emotion reactivity were significantly associated with lower levels of global distress tolerance (12.5% unique variance) and the four specific distress tolerance domains: tolerance (8.6% unique variance), absorption (11.4% unique variance), appraisal (8% unique variance), and regulation (8.1% unique variance). These findings suggest that individuals who tend to react more strongly to their emotions have greater difficulty tolerating emotional distress, and interventions that target emotion reactivity may be an effective way to improve distress tolerance and reduce the risk of developing psychopathology among undergraduates.
“Formal Thought Disorder” in a General-Community Sample With Elevated Schizotypal Traits
Authors: Deyo Cliff , Langdon Robyn 
Published: April 2019

Abstract
Different dimensions of formal thought disorder (FTD) are distinguished by different patterns of cognitive dysfunction and cortical variability in patients with schizophrenia; however, inconsistent findings may relate to patient-related confounds. Investigating FTD in nonpatient samples with elevated levels of schizotypal traits avoids these confounds, but its utility to FTD research is unknown. Thus, we performed principal components analysis (PCA) of FTD ratings using the Scale for the Assessment of Thought, Language, and Communication (TLC) and the Thought and Language Index (TLI) in a general-community sample with elevated schizotypal traits. Both scales showed “clinically elevated” FTD, particularly, the TLC. PCA described a three-component TLC solution (“disorganization,” “verbosity,” “emptiness”) and a two-component TLI solution (“negative,” “idiosyncratic”), generally consistent with schizophrenia research. TLC “disorganization” and “emptiness” were correlated with psychosis-like experiences. TLI “negative” was associated with lower general cognitive function, consistent with schizophrenia research. FTD may have shared etiology along the schizophrenia spectrum.
A multicenter observational study on the distribution of orthopaedic fracture types across 17 low- and middle-income countries
Authors: Pouramin Panthea , Li Chuan Silvia , Sprague Sheila , Busse Jason W. , Bhandari Mohit 
Published: April 2019

Abstract

Objectives:
To describe the regional distribution of fractures sustained by women and health care system characteristics across 17 low- and middle-income countries (LMICs).

Methods:
The INternational ORthopaedic MUlticentre Study in fracture care (INORMUS) is an observational study collecting data on patients in LMICs who sustained a fracture or musculoskeletal injury. As a planned analysis for the INORMUS study, we explored differences in fracture locations and demographics reported among 9878 female patients who sustained a fracture within 17 LMICs in 5 regions (China, Africa, India, Other Asia, and Latin America).

Results:
Half of our study population (49.6%) was ≥60 years of age. Across all regions, 58.3% of patients possessed health insurance. Latin America possessed the highest proportion (88.8%) of health insurance, while in Africa, patients possessed the lowest (18.0%). Falls from standing were the most prevalent mechanism of injury (51.7%) followed by falls from height (12.8%) and motorcycle-related road traffic injuries (9.7%). The majority of the fractures (65.6%) occurred in patients aged 50 and older. Hip fractures were the most common fracture (26.8%), followed by tibia/fibula (12.6%) and spine fractures (9.7%). Open fractures accounted for 7.6% of fractures and were most commonly tibia/fibula fractures (35.1%). Despite these severe injuries, less than one-third (28.8%) of patients were transported for care after sustaining a fracture by ambulance. Regionally, a majority of female patients in Africa were working age and suffered tibia/fibula (21.6%) and femur fractures (14.0%). Patients in the regional category Other Asia, suffered the highest frequencies of open fractures (9.6% low grade, 7.1% high grade), and disproportionately from motorcycle road traffic injuries (29.9%).

Conclusion:
Across all regions, the most significant source of fracture burden was in the elderly, and included common fragility fractures, such as hip fractures. Notable regional deviations in fracture distributions were observed within Africa, and Other Asia. Across all studied LMICs, ambulance usage was low, and health insurance coverage was particularly low in Africa and India.
Nasal Septum Defects Detected on Postmortem Computed Tomography
Authors: Chatzaraki Vasiliki , Schweitzer Wolf , Thali Michael J. , Ampanozi Garyfalia 
Published: April 2019

Abstract
Nasal septum defects may have forensic relevance because they are associated with various mechanisms, including trauma and cocaine abuse. Like all human body tissues, the nasal septum may be affected by maggots' infestation during postmortem decomposition. Postmortem computed tomography (PMCT) can reveal small findings and related details. Three cases of early postmortem period and 2 cases of advanced decomposition, where external examination of the nasal cavities and PMCT revealed nasal septum defect, are presented. In the early postmortem period cases, the lesions' edges appeared smoother on PMCT, whereas in the advanced decomposed cases, the edges were irregular and maggots were infested. Postmortem computed tomography can detect nasal septum defects and may help differentiate the preexisting from the postmortem ones based on their edges' radiological appearance. Such findings may indicate possible chronic cocaine abuse (cocaine nose), trauma, or other nasal pathology. It is important to note that such defects may be altered or caused by advanced decomposition.
Leaving Without Being Seen From a Pediatric Emergency Department
Authors: Moskalewicz Risha L. , Pham Phung K. , Liberman Danica B. , Hall Jeanine E. 
Published: April 2019

Objective
National rates of left (or leaving) without being seen (LWBS) in pediatric emergency departments (PED) are higher than general emergency departments. We investigated coexisting perspectives on LWBS.

Methods
Q-methodology was implemented through a mixed-methods design. Semistructured interviews elicited a concourse of caregivers' thoughts on waiting in the PED and their consideration of LWBS. Themes from the concourse were identified and framed as statements. Caregivers sorted these statements, which ranged from choosing to stay versus leave the PED before their child is seen by a physician. Sorted data were analyzed through centroid factor analysis.

Results
Seventy-seven caregivers contributed interview data, from which 31 themes were identified and framed as statements. Thirty-one different caregivers contributed Q-sort data, from which 2 factors were revealed, each representing a unique perspective on LWBS. Most caregivers (26 of 31) shared the following perspective: “I would leave the PED before my child is seen by a doctor if there are no reassessments for my child while we are in the queue, no updates on our queue position, or no explanations for wait time.” The remaining caregivers (5 of 31) perceived feelings of uncertainty and helplessness, lack of updates, and competing obligations as primary influences on LWBS.

Conclusions
Elements that factor into caregivers' decision to LWBS from a PED include lack of reassessments, lack of updates on queue position, and lack of information about the triage process. Quality improvement interventions for decreasing LWBS rates should account for diverse coexisting perspectives such as these.
Development of a Clinical Prediction Model for Central Line–Associated Bloodstream Infection in Children Presenting to the Emergency Department
Authors: Figueroa-Phillips Laura M. , Bonafide Christopher P. , Coffin Susan E. , Ross Michelle E. , Guevara James P. 
Published: April 2019

Objective
The majority of the children with a central line who present to the emergency department with fever or other signs of bacteremia do not have a central line–associated bloodstream infection (CLABSI). Our objective was to develop a clinical prediction model for CLABSI among this group of children in order to ultimately limit unnecessary hospital admissions and antibiotic use.

Methods
We performed a nested case-control study of children with a central line who presented to the emergency department of an urban, tertiary care children's hospital between January 2010 and March 2015 and were evaluated for CLABSI with a blood culture.

Results
The final multivariable model developed to predict CLABSI consisted of 12 factors: age younger than 5 years, black race, use of total parenteral nutrition, tunneled central venous catheter, double-lumen catheter, absence of other bacterial infection, absence of viral upper respiratory tract infection symptoms, diarrhea, emergency department temperature greater than 39.5°C, fever prior to presentation, neutropenia, and spring/summer season. The clinical prediction score had good discrimination for CLABSI with a c-statistic of 0.81 (confidence interval, 0.77–0.85). A cut point less than 6 was associated with a sensitivity of 98.5% and a negative predictive value of 99.2% for CLABSI.

Conclusions
We were able to identify risk factors and develop a clinical prediction model for CLABSI in children presenting to the emergency department. Once validated in future study, this clinical prediction model could be used to assess the need for hospitalization and/or antibiotics among this group of patients.
Image Fusion: A Novel Approach in Gamma Knife Surgery Treating Trigeminal Neuralgia
Authors: Tang Ke , Zhao Yaqun , Yu Jianchen , Gao Hao , Gao Dongxiao , Di Cuili , Wang Yuping 
Published: April 2019

Objective:
Finding accurate locations for radiosurgical targets in trigeminal neuralgia (TN) remains challenging. This study provides a novel approach of image fusion used in locating radiosurgical targets for gamma knife surgery (GKS) in the treatment of TN.

Methods:
Magnetic resonance imaging (MRI) scans were performed before frame fixation, and computed tomography (CT) scans were performed following frame fixation. Fusion of the CT and MRI images was performed to locate the treatment target. The therapeutic effects were evaluated following GKS.

Results:
The CT image ensures precise imaging for defining the fiducial localizers. Multi-modality medical imaging allows the trigeminal nerve (CN V) to be distinguished from the adjacent corresponding vessels. Thus, image fusion makes isocenter positioning more accurate. Significant changes in the frequency, intensity, and length of pain attacks following GKS were achieved.

Conclusion:
Diagnostic MRI co-registered with stereotactic CT can be used for accurate target location. The therapeutic effects of image fusion for GKS treatment of TN are satisfactory.