bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overexpression of p63 Protein in Patients with Seborrheic Keratosis in the Setting of Carbohydrate Metabolism Disorders
Authors: Alexandrova A. К. , Smolyannikova V. A. 
Published: September 2019

Aim. The paper studies p63 expression in patients with seborrheic keratosis in the presence or absence of carbohydrate metabolism disorders.Materials and methods. The study involved 130 patients with seborrheic keratosis. Following the endocrinologist’s consultation, the patients were divided into two groups. The fi rst group comprised 68 people: 44 patients with type 2 diabetes and 24 patients with impaired glucose tolerance. The second group was composed of patients without carbohydrate metabolism disorders (62 people). The authors performed a histological study and an immunohistochemical (IHC) test using monoclonal antibodies to р63. The results of the IHC test were analysed according to the number of stained tumour cells: 0 — no response or weak staining of less than 10% of the cells, 1 — from 10% to 30% of tumour cells are stained, 2 — staining of more than 30% of tumor cells; as well as according to the colour intensity: weak (+) and marked (++).Results. The IHC test using monoclonal antibodies to р63 produced a positive reaction in 82.3% of cases. Sixty-fi ve seborrheic keratomas (SK) (50%) exhibited a diffuse pronounced expression of p63. Weak nuclear staining (10%–30% of cells) was recorded in 42 SKs (32.3%). The study revealed a high correlation dependence of p63 expression in SK on the presence of carbohydrate metabolism disorders in patients (R = 0.82, p = 0.0000001). Thus, in patients with carbohydrate metabolism disorders, overexpression of p63 in SKs was found to be signifi cantly higher — 89.7%, as compared to 6.4% in patients without impaired carbohydrate metabolism (p = 0.00001).Conclusion. P63 overexpression in seborrheic keratosis correlates with the presence of chronic hyperglycemia in patients. Disruption of cellular metabolism leads to changes in the balance between p63 isoforms and plays an important role in the pathogenesis of seborrheic keratosis.
Ultrasonic Elastography in the Differential Diagnosis of Thyroid Nodular Patholog
Authors: Timofeeva L. A. , Tukhbatullin M. G. , Sencha A. N. 
Published: September 2019

Aim.In this study, we set out to determine the informative value of multi-parametric ultrasound examination using ultrasound elastography in the differential diagnosis of thyroid nodular neoplasms.Materialsand methods. We analysed 229 multi-parametric ultrasound examinations of patients in the preoperative period in order to assess the effectiveness of strain elastography (SE) and shear wave elastography (SWE) drawing on the example of ARFI and Strain Ratio. Two patient groups were formed. The fi rst group (N1=93) included patients with thyroid cancer, whereas the second one (N2=136) was composed of patients with benign thyroid nodules (thyroid adenoma and follicular or colloid goitre). The control group consisted of 174 patients with unchanged thyroid parenchyma. SE visualised tissue elasticity as a colour map. Shear wave elastography (SWE) — ARFI and Strain Ratio techniques — was performed using the following ultrasonic apparatuses: Acuson S-2000 (Siemens, Germany), Ultrasonix SP (Sonix, Canada) and Mindray DC-8 (Mindray, China).Results.According to the obtained data (SE technique), the parenchyma of the unchanged thyroid gland exhibited heterogeneous, uneven fi ne / moderately granular, symmetrical staining (96.6%). Thyroid cancer was characterised by a shear wave velocity (ARFI) of greater than 3.57 m/s, as well as a density ratio (elasticity modulus and Strain Ratio) of more than 1.56.Conclusion.The study revealed that the application of ultrasound elastography is highly informative in the comprehensive diagnosis of thyroid nodular neoplasms and should be used when thyroid cancer is suspected to ascertain the size of nodules, as well as the tumour invasion into surrounding tissues.
Constitución Española de Cádiz 1812
Authors: Carrión Perez Alejandro 
Published: September 2019

Los siguientes siete artículos son el resultado de la celebración de “Las Jornadas de Estudio Conmemorativas del Bicentenario de la Constitución de Cádiz” que se realizaron en la ciudad de Quito en octubre de 2013. El resultado aquí presentado ha profundizado en el estudio de las circunstancias que rodearon la promulgación de la Constitución liberal española de 1812, con todo el significado y consecuencias que tuvo para la América española.
Se ha realizado un estudio exhaustivo de la situación en la antigua Audiencia de Quito. Se ha analizado los aspectos políticos, sociales, económicos y regionales que se desarrollaron en el primer cuarto del siglo XIX y que tanto influyeron en el desarrollo del Ecuador moderno.
Kajian Strategi Pemasaran Ubi Cilembu (Kasus di Desa Cilembu, Kecamatan Pamulihan, Kabupaten Sumedang)
Authors: Ervina Cordelia , Hubeis Musa , Pandjaitan Nora H. 
Published: September 2019

One of areas which producing sweet potato is Cilembu Village, located in Pamulihan Subdistrict, Sumedang Regency. The sweet Potato is famous as ubi Cilembu. The objectives of this research were to identify internal and external factors affecting raw material availability and continuity of marketing system of sweet potato Cilembu and to recommend alternative of effective and efficient marketing strategy of sweet potato Cilembu. This research used purposive sampling and also primary and secondary data. Respondents consisted of 30 people from 107 population of sweet potatoes Cilembu in Cilembu village. Analysis was conducted using IFE and EFE matrix, internal-external (IE) matrix, SWOT and QSPM method. From several strategies by using QSPM method, it had chosen one strategy to boost Cilembu sweet potato marketing by KUCP. The strategy was to encourage efforts in creating processing business medium scale of Cilembu sweet potatoes in order to get competitive processed products.
Pemanfaatan Visual Literacy melalui Gambar untuk Memotivasi Siswa Belajar Bahasa Inggris
Authors: Budiharto R Agus , Amalia Laili , Fujiono Fujiono 
Published: September 2019

USING VISUAL LITERACY THROUGH IMAGES TO MOTIVATE STUDENTS TO LEARN ENGLISH. Existing in an image-rich world, as school students currently experience, does not mean that they naturally possess right visual literacy aptitudes as when they see an object (such as a picture), they just see what they see, they do not possess a considerable capability to understand, interpret, discover a meaning from an object or information they see. For that reason, students are supposed to possess visual literacy to perform that. Given the importance of utilizing visual literacy through a picture to motivate students in learning English, the writer of this article has the initiative to carry out community service to first-grade students of MTS Qurrotul Uyun. This community service discusses the utilization of visual literacy through colored pictures as a pedagogical tool, which can provide a precious and motivating resource for the students to learn English. The result of this community service suggests that English learning through colored pictures is potential to make the MTS Qurrotul Uyun first grade students motivated in learning pronunciation, speaking, and grammar. They feel that English learning through colored pictures in the classroom is more appealing and pleasurable as the pictures can both catch their mind attention and facilitate them to learn. Moreover, the colored pictures can make the MTS Qurrotul Uyun first grade students motivated and more involved actively in English learning.
Resolution of ST-Segment Depression In Reciprocal Leads As Predictor Mayor Adverse Cardiac Event For ST-Segment Elevation Myocardial Infarction With Fibrinolytic Therapy
Authors: Adhitya Aldino Satria , Sitepu Andika , Mukhtar Zulfikri , Hasan Harris 
Published: September 2019

Background: ST Elevation Myocardial Infarction (STEMI) may cause Major Cardiovascular Event (MACE). Revascularization needs to be done in all STEMI patients to restore coronary blood flow, hence saving myocardial perfusion. ST Segment Depression (STSD) in reciprocal ECG lead is associated with poor prognosis in STEMI patients receiving fibrinolytic therapy. The main purpose of this study is to evaluate MACE in STEMI patients receiving fibrinolytic therapy using resolution in STSD. Methods: This cohort prospective study with 60 subjects of STEMI patients which are evaluated for MACE (death, heart failure, and rehospitalization) within 30 days after myocardial infarction. Resolution in STSD is defined as resolution ≥ 50% STSD in reciprocal leads within 90 minutes after fibrinolytic therapy.Results: Bivariate analysis showed that Ejection fraction (EF) <40% with OR 8,32 (2,11-32,74), p=0,001; smoking with OR 4,17 (1,05-16,57), p=0,034; Anterior STEMI with OR 3,94 (1,11-13,90), p= 0,027; Creatinine > 1,97 mg/dl with OR 3,69 (1,18-11,55), p= 0,022; complete outpatient medication with OR 5,23 (1,61-17,01), p= 0,004; fragmented QRS with OR 5,23 (1,61-17,01), p= 0,001; resolution in STSD with OR 26,35 (5,16-134, 40), p=<0,001; resolution in ST Segment Elevation with OR 10,5 (2,97-37,24), p=<0,001; are proven to be determining factor for MACE within 30 days. Multivariate analysis showed that among those determining factors for MACE, resolution in STSD on reciprocal leads is evidently the most dominant factor for predicting MACE within 30 days in STEMI patients receiving fibrinolytic therapy [OR 11.47 (1.14-115.10), p=0.038].Conclusion: There is significant difference in MACE within 30 days after myocardial infarction (MI) between patients with and without resolution in STSD. The subjects without resolution in STSD showed higher MACE incidence. Resolution in STSD is evidently an independent predictor for MACE within 30 days after myocardial infarction in STEMI patients.Keywords: Resolution in STSD, MACE, STEMI, Fibrinolytic
Tindakan Ablasi pada Fibrilasi Atrium Berasal dari Vena Kava Superior
Authors: Almazini Prima , Sinaka Gustaf David , Yugo Dony , Raharjo Sunu Budhi , Hanafy Dicky Armein , Yuniadi Yoga 
Published: September 2019

Latar Belakang: Fibrilasi atrium (FA) merupakan aritmia yang paling sering ditemukan. Fibrilasi atrium membutuhkan adanya pemicu untuk inisiasi dan substrat untuk mempertahankan aritmia. Fokus tunggal atau multipel sebagai pemicu, paling sering di vena pulmonal tetapi dapat juga berasal dari selain vena pulmonal, seperti di vena kava superior. Patofisiologi aritmia di vena kava superior masih belum dapat dipahami.
Ilustrasi Kasus: Seorang perempuan, 72 tahun, datang ke poliklinik Pusat Jantung Nasional Harapan Kita (PJNHK) dengan keluhan utama sering berdebar-debar. Pasien pertama kali mengeluh berdebar-debar pada tahun 2000, namun baru pada tahun 2007 pasien melakukan pemeriksaan dan terapi dengan obat-obatan serta dilakukan tindakan ablasi FA. Pada tahun 2010, pasien mengeluh berdebar-debar kembali dan dapat dikontrol dengan terapi medikamentosa. Pada tahun 2016, pasien menjalani tindakan ablasi kedua dengan hasil berhasil dilakukan isolasi vena pulmonal dan angiografi koroner memperlihatkan arteri koroner normal. Pasien sempat datang ke UGD PJNHK bulan Mei 2017 dengan keluhan berdebar dan hasil pemeriksaan EKG saat di UGD menunjukkan irama FA. Dilakukan tindakan ablasi ketiga dengan hasil berhasil dilakukan isolasi vena kava superior.
Kesimpulan: Vena kava superior dapat berperan sebagai pemicu atau substrat fibrilasi atrium. Sebagai fokus, selain vena pulmonal, yang paling sering menjadi sumber fibrilasi atrium, vena kava superior menjadi target penting saat tindakan ablasi fibrilasi atrium.
CHA2DS2-VAS-HSF Score as a Predictor for Contrast- Induced Nephropathy in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention
Authors: Parlindungan Herman William , Hasan Refli , Andra Cut Aryla , Akbar Nizam Zikri , Nasution Ali Nafiah , Hasan Harris , Safri Zainal , Lubis Anggia C , Napitupulu Bertha Gabriella 
Published: September 2019

Background: Contrast-Induced Nephropathy (CIN) is a serious problem that can be found in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). The development of CIN in hospitalized patients even with coronary revascularization can immediately increase morbidity and mortality both during treatment and long-term outcomes. In a recent study, a CHA2DS2-VASC-HSF score was reported to predict coronary artery severity and major cardiovascular events (MACE) as well as CIN in AMI patients without atrial fibrillation. The purpose of this study was to investigate the CHA2DS2-VASC score as a predictor of CIN in AMI patients undergoing PCI procedures.
Methods: This study was an ambispective cohort study of 53 AMI patients who were treated at cardiac care and underwent PCI procedures. The CHA2DS2-VASC-HSF score was calculated for each patient. From this study found 14 cases (26.4%) with a total CIN prevalence of 16.83%. CIN is defined as an increase in serum creatinine> 0.5 mg / dL or an increase in serum creatinine> 25% from baseline within 24 hours post PCI.
Results: Through the analysis of the ROC curve, we established the CHA2DS2- VASC-HSF score cut point> 5 as a predictor of CIN with a sensitivity of 78.57% and specificity of 66.6 %% (AUC 0.818, 95%: CI 3.018-6.142, p <0.001). By getting the equation from the linear regression assessment we also found the probability of the occurrence of CIN in accordance with the CHA2DS2-VASC-HSF score.
Conclusion: CHA2DS2-VASC score has a positive correlation with CIN. Therefore, this score can be used as a simple scoring system and can predict the incidence of CIN in AMI patients undergoing PCI procedures.
Defisiensi vitamin D pada pasien gagal jantung kronik yang menjalani rawat inap
Authors: Hartanto Yanuar Budi , Sugiri Sugiri , Anggriyani Novi , Herry Yan , Bahrudin Udin 
Published: September 2019

Latar Belakang: Gagal jantung merupakansalah satu masalah kesehatan masyarakat global dengan jumlah penderita yang diperkirakan terus mengalami peningkatan. Meskipun terdapat kemajuan dalam tata kelolanya, gagal jantung masih memiliki prognosis yang buruk. Vitamin D merupakan mikronutrien yang berpengaruh terhadap prognosis pasien gagal jantung kronik. Saat ini belum ada data mengenai kadar vitamin D serum pada pasien gagal jantung kronik yang dirawat pada populasi Indonesia. Tujuan penelitian ini adalah untuk mengetahui kadar vitamin D serum pada pasien gagal jantung kronik yang menjalani rawat inap.Metode: Penelitian observasional pada pasien gagal jantung kronik yang dirawat di RSUP. Dr. Kariadi Semarang mulaibulan November 2017 sampaiJanuar1 2018. Pemeriksaan kadar vitamin D serum [25(OH)D] dilakukan dengan metode chemiluminescence immunoassay (CLIA).Hasil: Sebanyak 102 pasien (median usia 55 (22–65) tahun) yang terlibat, terdapat 69 sampel yang memenuhi kriteria seleksi. Median fraksi ejeksi ventrikel kiri adalah 35 (10-76)%. Median kadar vitamin D serum adalah 47.25 (14.25–143.02) nmol/L.Yang menarik, 88,4% pasien menunjukkan kadar vitamin D lebih rendah dari yang direkomendasikan. Dibandingkan dengan pasien dengan kadar vitamin D normal, pasien dengan kadar rendah tersebut lebih sering disertai denganhipertensi atau diabetes, berjenis kelamin perempuan, dan memiliki riwayat rawat inap ulang yang lebih sering.Kesimpulan: Defisiensi vitamin D serum dialami olehsebagian besar pasien gagal jantung kronik yang dirawat. Data ini menunjukkan perlunya pengukuran kadar vitamin D pada pasien gagal jantung kronik dengan hipertensi, diabetes, jenis kelamin wanita dan rawat inap ulang.Kata Kunci : Gagal jantung, defisiensi vitamin D, rawat inap
The Hypoxic Preconditioning Effect On Senescence Cell Process In Cultured Adipose-Derived Mesenchymal Stem Cells (AMSCs)
Authors: Nuarisa Nadiar Dwi , Suryawan I Gde Rurus , Andrianto Andrianto 
Published: September 2019

Introduction : Stem cell therapy for myocardial regeneration is expected to increase cardiomyocyte proliferation and trigger neovascularization to improve cardiomyocytes. Mesenchymal Stem Cells (MSCs) are ideal candidates for regenerative medicine and immunotherapy. But low viability of MSCs is a major challenge in this alternative therapy. Therefore, a cytoprotective strategy is needed, one of them is hypoxic preconditioning which can significantly increase survival stem cells after being transplanted. MSCs are known to have a limited life span, after experiencing several splits MSC will enter the senescence process. It is known that hypoxia can also increase cell proliferation and differentiation potential in vitro and in vivo through the role of Octamer-4 (Oct-4) as a regulator of the pluripotency gene.
Methods : Experimental laboratory studies (in vitro studies) using human-AMSCs which were given hypoxic preconditioning, observed as a immunocytochemistry.
Results : The results showed that hypoxic precondition (1% O2) inhibited the senescence process. It can be seen in the lower expression of senescence in hypoxic conditions at P6, P7, P8, P9, P10 compared to normoxic ((p=0,004, p=0,001, p=0,009, p=0,013, p=0,024. There is a significant difference in the senescence expression of each passage in hypoxic and normoxic conditions with the highest expression at P10. In addition, we also observed AMSCs differentiation through the Oct-4 expression. It is showed that Oct-4 expression were higher in hypoxia compared to normoxia on P7, P8, P9, P10 (p=0,009, p=0,009, p=0,030, p=0,0001).
Conclusions : Hypoxic preconditioning have the effect of inhibiting the senescence process on Adipose-derived MSCs (AMSCs) or prolonging their life span. The longer life span of AMSCs is also seen by higher cell differentiation potential from increased expression of Oct-4. However, the mechanism of inhibiting the senescence process in hypoxia in stem cells is still remain unknown.
Keywords: human-Adipose derived Mesenchymal Stem Cell Cultures (h-AMSCs), Hypoxic Preconditioning, Senescence cell, Oct-4.
Improvement of level MDA and SOD Using of Ganoderma Lucidum as Adjunctive Treatment for Statin Based Therapy in High Risk Patient Based on Framingham Score
Authors: Vitriyaturrida Vitriyaturrida , Rohman M Saifur , Sargowo Djanggan , Hendrawan Dadang 
Published: September 2019

It is well known from previous research on the importance of antioxidants to inhibit the progression of coronary heart disease in high-risk patients based on framingham scores. Statins are routinely administered in high-risk patients based on the Dyslipidemia 2016 ESC guidelines but the effects of adding Ganoderma are known to have antioxidant effects, in patients who have received statins. This study aims to assess the effect of antioxidants through measurement of SOD and MDA in patients given a combination of Ganoderma lucidum with statins.Method: A total of 24 patients with high-risk patients based on the Framingham score > 20% were selected as sample of study. Patients with respondents who had never received statin therapy or ACEi or ARB or CCB or beta blocker, or did not routinely consume the drug for 2 weeks were excluded from this study. The addition of Ganoderma lucidum dose of 3x250 mg was added to statins as the first group and Ganoderma lucidum dose of 3x250 mg was added to the Statin combination of Angiotensin Converting Enzym inhibitors (ACE inhibitors) or Angiotensin Receptor Blockers (ARB) and or Calcium Channel Blockers (CCB) and or Beta blockers as second group for 90 days. SOD and MDA levels were measured before and after the administration of Ganoderma Lucidum with the ELISA method.Result: After the administration of Ganoderma Lucidum with standard therapy, there was a decrease in MDA levels and an increase in SOD levels after 90 days in two groups. Conclusion: The addition of Ganoderma Lucidum to standard therapy can reduce oxidant levels in high-risk patients based on framingham scores.
Keyword: Superoxyde-dismutase, Malondyaldehide, Oxidative Stress, Antioxidant, Ganoderma Lucidum, Statin
PERANAN ACETAMINOPHEN (PARASETAMOL) DALAM PENUTUPAN DUCTUS ARTERIOSUS
Authors: Dimiati Herlina , Fasli Rini 
Published: September 2019

Abstrak
Patent ductus arteriosus (PDA) adalah kelainan kongenital yang ditandai adanya kegagalan penutupan duktus arteriosus (DA) segera setelah lahir. Dampak tidak menutupnya DA akan terjadi gangguan hemodinamik ,memperberat masalah lain yang menyertai bayi prematur sehingga akan meningkatkan morbiditas dan mortalitas. Parasetamol merupakan obat yang relatif baru digunakan untuk menutup PDA jika dibandingkan dengan indometasin ataupun ibuprofen dengan tinkat keberhasilan yang tinggi.
Kata kunci: Patent ductus arteriosus (PDA), gangguan hemodinamik, parasetamol
Abstract
Patent ductus arteriosus (PDA) is a congenital disorder characterized by a failure to close the ductus arteriosus (DA) immediately after birth. The impact of not closing the DA will occur hemodynamic disturbances, aggravating other problems that accompany premature babies so that it will increase morbidity and mortality. Paracetamol is a relatively new drug used to close PDAs when compared with indomethacin or ibuprofen with the high success rates.
Keywords: Patent ductus arteriosus (PDA), hemodynamic problem, paracetamol
Aritmia Ventrikel Pasca Intervensi Koroner Perkutan : Petanda Reperfusi atau Iskemia yang Masih Berlangsung ?
Authors: Putra Meidianaser , Rasyid Hauda El 
Published: September 2019

Aritmia ventrikel setelah IKP awalnya diindikasikan sebagai reperfusi yang sukses. Namun, beberapa penelitian menyebutkan bahwa aritmia ini diakibatkan oleh iskemia yang sedang berlangsung. Aritmia yang sering terjadi adalah kontraksi ventrikel premature sustained atau nonsustained takikardi ventrikel, accelerated idioventricular tachycardia, fibrilasi atrium, dan fibrilasi ventrikel. Gangguan irama dihubungkan dengan oklusi koroner didefinisikan sebagai aritmia iskemik, sedangkan aritmia terjadi akibat peningkatan perfusi miokard yang disebut aritmia reperfusi. Accelerated idioventricular tachycardiabisa menjadi penanda dari reperfusi awal dan patensi arteri berkelanjutan.
Penatalaksanaan aritmia ventrikel pasca intervensi koroner perkutan meliputi penggunaan obat anti aritmia, overdrive pacing, ablasi radiofrekuensi, dan ICD.
Kata kunci: aritmia ventrikel, IKP, obat anti aritmia, overdrive pacing, ablasi radiofrekuensi, dan ICD
CORELATION OF GLOBAL LONGITUDINAL STRAIN (GLS) – LEFT VENTRICLE AND SOLUBLE SUPRESSION OF TUMORGENICITY 2 (sST2) IN ACUTE HEART FAILURE WITH SYSTOLIC DYSFUNCTION
Authors: Yulidia Herlina , Aminuddin Muhammad , Pikir Budi S 
Published: September 2019

Background : Assessment of left ventricular function in patients with acute heart failure is important for prognostication, determination of treatment plan, for decisions related to expensive device therapies and for assessing response to treatment. Echocardiography is the "gold standard" of assessing left ventricular function, and in establishing a diagnosis of heart failure. Left ventricular Global Longitudinal Strain (GLS) assessed through Speckle Tracking Echocardiography (STE) is currently considered sensitive in assessing left ventricular motion, by analyzing multidimensional myocardial deformation
. s ST2 used to be correlated with stretch miocard and inhibid ligand of IL-33 wich also inhibit the cardioprotectve effect.
Objective : To prove the positive correlation between GLS-left ventricle with soluble ST2.
Methods : This is a correlational study with cosecutive sampling technique. Thirty subjects participate in this reseach and each subject underwent echocardiography and GLS-left ventricle and soluble ST2 blood examination. The correlation between GLS-left ventricle and soluble ST2 were evaluated using Spearman correlation test.
Results : There is a strong, significant, positive correlation between the GLS-left ventricle with soluble ST2 (r = 0.99 and p = 0.0001).
Conclusion : There is a strong, significant, positive correlation between the GLS- left ventricle with soluble ST2.
Keywords : acute heart failure, systolic dysfunction, global longitudinal strain, soluble ST2.