bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells
Authors: Shang Hung‐Sheng , Lu Hsu‐Feng , Lee Ching‐Hsiao , Chiang Han‐Sun , Chu Yung‐Lin , Chen Ann , Lin Yuh‐Feng , Chung Jing‐Gung 
Published: August 2018

AbstractQuercetin is one of the natural components from natural plant and it induces cell apoptosis in many human cancer cell lines. However, no available reports show that quercetin induces apoptosis and altered associated gene expressions in human gastric cancer cells, thus, we investigated the effect of quercetin on the apoptotic cell death and associated gene expression in human gastric cancer AGS cells. Results indicated that quercetin induced cell morphological changes and reduced total viability via apoptotic cell death in AGS cells. Furthermore, results from flow cytometric assay indicated that quercetin increased reactive oxygen species (ROS) production, decreased the levels of mitochondrial membrane potential (ΔΨm), and increased the apoptotic cell number in AGS cells. Results from western blotting showed that quercetin decreased anti‐apoptotic protein of Mcl‐1, Bcl‐2, and Bcl‐x but increased pro‐apoptotic protein of Bad, Bax, and Bid. Furthermore, quercetin increased the gene expressions of TNFRSF10D (Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain), TP53INP1 (tumor protein p53 inducible nuclear protein 1), and JUNB (jun B proto‐oncogene) but decreased the gene expression of VEGFB (vascular endothelial growth factor B), CDK10 (cyclin‐dependent kinase 10), and KDELC2 (KDEL [Lys‐Asp‐Glu‐Leu] containing 2) that are associated with apoptosis pathways. Thus, those findings may offer more information regarding the molecular, gene expression, and signaling pathway for quercetin induced apoptotic cell death in human gastric cancer cells.
Multivariate ordinal regression models: an analysis of corporate credit ratings
Authors: Hirk Rainer , Hornik Kurt , Vana Laura 
Published: August 2018

AbstractCorrelated ordinal data typically arises from multiple measurements on a collection of subjects. Motivated by an application in credit risk, where multiple credit rating agencies assess the creditworthiness of a firm on an ordinal scale, we consider multivariate ordinal regression models with a latent variable specification and correlated error terms. Two different link functions are employed, by assuming a multivariate normal and a multivariate logistic distribution for the latent variables underlying the ordinal outcomes. Composite likelihood methods, more specifically the pairwise and tripletwise likelihood approach, are applied for estimating the model parameters. Using simulated data sets with varying number of subjects, we investigate the performance of the pairwise likelihood estimates and find them to be robust for both link functions and reasonable sample size. The empirical application consists of an analysis of corporate credit ratings from the big three credit rating agencies (Standard & Poor’s, Moody’s and Fitch). Firm-level and stock price data for publicly traded US firms as well as an unbalanced panel of issuer credit ratings are collected and analyzed to illustrate the proposed framework.
Archimedean Metanorms
Authors: Carter J. Adam 
Published: August 2018

AbstractOne notable line of argument for epistemic relativism appeals to considerations to do withnon-neutrality: in certain dialectical contexts—take for instance the famous dispute between Galileo and Cardinal Bellarmine concerning geocentrism—it seems as though a lack of suitably neutral epistemic standards that either side could appeal to in order to (non-question-beggingly) resolve their first-order dispute is itself—as Rorty (Philosophy and the mirror of nature, Princeton University Press, Princeton, 1979) influentially thought—evidence for epistemic relativism. In this essay, my aim is first to present a more charitable reformulation of this line of reasoning, one that is framed not merely in terms of the availability of epistemic norms that aresuitably neutralbetween interlocutors, but in terms of the availability of what I callArchimedean metanorms. Once this more charitable line of argument is developed, I show how, even though it avoids problems that face ‘non-neutrality’ versions of the argument, it nonetheless runs into various other problems that appear ultimately intractable and, further, that the strategy in question gives us no decisive reason to draw the relativist’s conclusion rather than the Pyrrhonian sceptic’s.
Fine particulate matter (PM2.5): The culprit for chronic lung diseases in China
Authors: Li Tao , Hu Rong , Chen Zi , Li Qiyuan , Huang Shouxiong , Zhu Zhou , Zhou Lin‐Fu 
Published: August 2018

AbstractAir pollution is a world public health problem. Particulate matter (PM), a mix of solid and liquid particles in the air, becomes an increasing concern in the social and economic development of China. For decades, epidemiological studies have confirmed the association between fine particle pollutants and respiratory diseases. It has been reported in different populations that increased fine particulate matter (PM2.5) concentrations cause elevated susceptibility to respiratory diseases, including acute respiratory distress, asthma, chronic obstructive pulmonary disease, and lung cancer. This review will discuss the pathophysiology of PM2.5 in respiratory diseases, which are helpful for the prevention of air pollution and treatment of respiratory tract inflammatory diseases.
CIRCpedia v2: An Updated Database for Comprehensive Circular RNA Annotation and Expression Comparison
Authors: Dong Rui , Ma Xu-Kai , Li Guo-Wei , Yang Li 
Published: August 2018

Abstract
Circular RNAs (circRNAs) from back-splicing of exon(s) have been recently identified to be broadly expressed in eukaryotes, in tissue- and species-specific manners. Although functions of most circRNAs remain elusive, some circRNAs are shown to be functional in gene expression regulation and potentially relate to diseases. Due to their stability, circRNAs can also be used as biomarkers for diagnosis. Profiling circRNAs by integrating their expression among different samples thus provides molecular basis for further functional study of circRNAs and their potential application in clinic. Here, we report CIRCpedia v2, an updated database for comprehensive circRNA annotation from over 180 RNA-seq datasets across six different species. This atlas allows users to search, browse, and download circRNAs with expression features in various cell types/tissues, including disease samples. In addition, the updated database incorporates conservation analysis of circRNAs between humans and mice. Finally, the web interface also contains computational tools to compare circRNA expression among samples. CIRCpedia v2 is accessible at http://www.picb.ac.cn/rnomics/circpedia.
A ten-year review of healthcare-associated bloodstream infections from forty hospitals in Québec, Canada
Authors: Fakih Iman , Fortin Élise , Smith Marc-André , Carignan Alex , Tremblay Claude , Villeneuve Jasmin , Moisan Danielle , Frenette Charles , Quach Caroline ,   for SPIN-BACTOT
Published: August 2018

AbstractObjectiveHealthcare-associated bloodstream infections (HABSI) are a significant cause of morbidity and mortality worldwide. In Québec, Canada, HABSI arising from acute-care hospitals have been monitored since April 2007 through the Surveillance des bactériémies nosocomiales panhospitalières (BACTOT) program, but this is the first detailed description of HABSI epidemiology.MethodsThis retrospective, descriptive study was conducted using BACTOT surveillance data from hospitals that participated continuously between April 1, 2007, and March 31, 2017. HABSI cases and rates were stratified by hospital type and/or infection source. Temporal trends of rates were analyzed by fitting generalized estimating equation Poisson models, and they were stratified by infection source.ResultsFor 40 hospitals, 13,024 HABSI cases and 23,313,959 patient days were recorded, for an overall rate of 5.59 per 10,000 patient days (95% CI, 5.54–5.63). The most common infection sources were catheter-associated BSIs (23.0%), BSIs secondary to a urinary focus (21.5%), and non–catheter-associated primary BSIs (18.1%). Teaching hospitals and nonteaching hospitals with ICUs often had rates higher than nonteaching hospitals without ICUs. Annual HABSI rates did not exhibit statistically significant changes from year to year. Non–catheter-associated primary BSIs were the only HABSI type that exhibited a sustained change across the 10 years, increasing from 0.69 per 10,000 patient days (95% CI, 0.59–0.80) in 2007–2008 to 1.42 per 10,000 patient days (95% CI, 1.27–1.58) in 2016–2017.ConclusionsDespite ongoing surveillance, overall HABSI rates have not decreased. The effect of BACTOT participation should be more closely investigated, and targeted interventions along alternative surveillance modalities should be considered, prioritizing high-burden and potentially preventable BSI types.
Drag on flat plates of arbitrary porosity
Authors: Steiros K. , Hultmark M. 
Published: August 2018

A new model for the drag force on a two-dimensional flat plate of arbitrary porosity, oriented normal to the free stream, is introduced. The model is an extension of that introduced by Koo & James (J. Fluid Mech., vol. 60(3), 1973, pp. 513–538), where the performance at low porosities is improved by including a base-suction term. The additional drag due to the base suction is calculated implicitly using momentum theory, which makes the model self-contained. The model predictions exhibit convincing agreement with experimental observations over a wide range of porosities, including the solid case, as long as shedding is absent or suppressed.
Prevalence and risk factors of impaired fasting glucose and diabetes among Chinese children and adolescents: a national observational study
Authors: Wang Zhenghe , Zou Zhiyong , Wang Haijun , Jing Jin , Luo Jiayou , Zhang Xin , Luo Chunyan , Zhao Haiping , Pan Dehong , Ma Jun , Dong Bin , Ma Yinghua 
Published: August 2018

AbstractThe prevalence of impaired fasting glucose (IFG) and diabetes mellitus (DM) has reportedly increased significantly among Chinese children and adolescents. We aimed to examine the prevalence of IFG and DM, the disparities in sex and region and related risk factors among Chinese children and adolescents. A total of 16 434 Chinese children aged 6–17 years were selected from a national cross-sectional survey, and fasting glucose was measured for all participants. Overall, mean fasting plasma glucose (FPG) concentration was (4·64 (sd 0·51)) mmol/l, and the prevalence of DM and IFG was 0·10 and 1·89 %, respectively. Compared with girls, boys had higher FPG concentration (4·69 v. 4·58 mmol/l, r 0·107, P<0·001) and IFG prevalence (2·67 v. 1·07 %, rφ 0·059, P<0·001). Compared with rural children and adolescents, urban children and adolescent had higher FPG concentration (4·65 v. 4·62 mmol/l, r 0·029, P<0·001) and DM prevalence (0·15 v. 0·05 %, rφ 0·016, P<0·01). In addition, self-reported fried foods intake and overweight/obesity were positively associated with IFG, and the proportion of consuming fried foods more than or equal to once per week and overweight/obesity prevalence in boys and urban children and adolescents were significantly higher than girls and rural children and adolescents, respectively (P<0·05). Although the prevalence of IFG and DM was relatively low in Chinese children and adolescents, sex and region disparities were observed, which may be associated with differences in overweight/obesity prevalence and dietary factors.
Dietary intake of cod protein beneficially affects concentrations of urinary markers of kidney function and results in lower urinary loss of amino acids in obese Zucker fa/fa rats
Authors: Drotningsvik Aslaug , Midttun Øivind , McCann Adrian , Ueland Per Magne , Høgøy Ingmar , Gudbrandsen Oddrun Anita 
Published: August 2018

AbstractObesity increases the risk for developing kidney disease, and protection of kidneys through changes in diet should be investigated. Fish intake has been associated with reduced risk of developing kidney disease; therefore, we wanted to investigate whether cod protein intake could prevent or delay the development of kidney damage in an obese rat model that spontaneously develops proteinuria and focal segmental glomerulosclerosis. The aim of the study was to investigate any effects of cod protein intake on established markers of kidney function, amino acid composition, protein utilisation and growth in obese Zucker fa/fa rats in the early stage of decreased renal function. Male obese Zucker fa/fa rats (HsdOla:Zucker-Lepr) were fed cod muscle proteins in an amount corresponding to 25 % of dietary protein, with the remaining protein from a casein/whey mixture (COD diet). A control group was fed a diet with a casein/whey mixture as the only protein source (CAS diet). The intervention started when rats were 9–10 weeks old, and the rats were fed these diets for 4 weeks. At the end of the study, rats fed the COD diet had lower urine concentration of cystatin C, T-cell immunoglobulin mucin-1 (TIM-1), amino acids, carbamide, uric acid and ammonium and higher concentrations of creatine, trimethylamineN-oxide, 1-methylhistidine and 3-methylhistidine, lower kidney concentration of TIM-1 and showed better growth when compared with the CAS group. To conclude, cod protein may have the potential to delay the development of kidney damage in young obese Zucker rats and to improve protein utilisation and growth.
Vegetable and fruit intake and injurious falls risk in older women: a prospective cohort study
Authors: Sim Marc , Blekkenhorst Lauren C. , Lewis Joshua R. , Bondonno Catherine P. , Devine Amanda , Zhu Kun , Woodman Richard J. , Prince Richard L. , Hodgson Jonathan M. 
Published: August 2018

AbstractThe role of vegetable and fruit intake in reducing falls risk in elderly populations is uncertain. This study examined the associations of vegetable and fruit intake with falls-related hospitalisations in a prospective cohort study of elderly women (n 1429, ≥70 years), including effects on muscular function, which represented a potential causal pathway. Muscular function, measured using grip strength and timed-up-and-go (TUG), and vegetable and fruit intake, quantified using a validated FFQ, were assessed at baseline (1998). Incident falls-related hospitalisation over 14·5-year follow-up was captured by the Hospital Morbidity Data Collection, linked via the Western Australian Data Linkage System. Falls-related hospitalisation occurred in 568 (39·7 %) of women. In multivariable-adjusted models, falls-related hospitalisations were lower in participants consuming more vegetables (hazard ratio (HR) per 75 g serve: 0·90 (95 % CI 0·82, 0·99)), but not fruit intake (per 150 g serve: 1·03 (95 % CI 0·93, 1·14)). Only total cruciferous vegetable intake was inversely associated with falls-related hospitalisation (HR: per 20 g serve: 0·90 (95 % CI 0·83, 0·97)). Higher total vegetable intake was associated with lower odds for poor grip strength (OR: 0·87 (95 % CI 0·77, 0·97)) and slow TUG (OR: 0·88 (95 % CI 0·78, 0·99)). Including grip strength and TUG in the multivariable-adjusted model attenuated the association between total vegetable intake and falls-related hospitalisations. In conclusion, elderly women with higher total and cruciferous vegetable intake had lower injurious falls risk, which may be explained in a large part by better physical function. Falls reduction may be considered an additional benefit of higher vegetable intake in older women.
Identification and initial validation of empirically derived bipolar symptom states from a large longitudinal dataset: an application of hidden Markov modeling to the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study
Authors: Prisciandaro James J. , Tolliver Bryan K. , DeSantis Stacia M. 
Published: August 2018

AbstractBackgroundAlthough bipolar disorder (BD) is a fundamentally cyclical illness, a divided model of BD that emphasizes polarity over cyclicity has dominated modern psychiatric diagnostic systems since their advent in the 1980s. However, there has been a gradual return to conceptualizations of BD which focus on longitudinal course in the research community due to emerging supportive data. Advances in longitudinal statistical methods promise to further progress the field.MethodsThe current study employed hidden Markov modeling to uncover empirically derived manic and depressive states from longitudinal data [i.e. Young Mania Rating Scale and Montgomery–Asberg Depression Rating Scale responses across five occasions from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study], estimate participants’ probabilities of transitioning between these states over time (n = 3918), and evaluate whether clinical variables (e.g. rapid cycling and substance dependence) predict participants’ state transitions (n = 3229).ResultsAnalyses identified three empirically derived mood states (‘euthymic,’ ‘depressed,’ and ‘mixed’). Relative to the euthymic and depressed states, the mixed state was less commonly experienced, more temporally unstable, and uniquely associated with rapid cycling, substance use, and psychosis. Individuals assigned to the mixed state at baseline were relatively less likely to be diagnosed with BD-II (v. BD-I), more likely to present with a mixed or (hypo)manic episode, and reported experiencing irritable and elevated mood more frequently.ConclusionsThe results from the current study represent an important step in defining, and characterizing the longitudinal course of, empirically derived mood states that can be used to form the foundation of objective, empirical attempts to define meaningful subtypes of affective illness defined by clinical course.
Magnetic field effect on plasma parameters and surface modification of laser-irradiated Cu-alloy
Authors: Dawood Asadullah , Bashir Shazia , Chishti Naveed Ahmed , Khan Muhammad Asad , Hayat Asma 
Published: August 2018

AbstractThe effect of magnetic field on the plasma parameters and surface modification of Cu-alloy has been investigated. For this purpose, we have employed Nd: YAG laser at various irradiances ranging from 1.9 to 5 GW/cm2 to irradiate Cu-alloy under 5 torr pressure of argon, neon, and helium. The evaluated values of excitation temperature (Texc) and electron number density (ne) of Cu-alloy plasma explored by laser-induced breakdown spectroscopy technique are higher in the presence of 1.1 Tesla magnetic field as compared with field-free case. It is true at all irradiances as well as under all environmental conditions. It is also found that trends of both Texc and ne are increasing with increasing laser irradiance from 1.9 to 4.4 GW/cm2. For the highest used irradiance 5 GW/cm2, the decrease in both parameters is observed. The analytically calculated values of thermal beta, directional beta, confinement radius, and diffusion time for laser-irradiated Cu-alloy plasma confirm the validity of magnetic confinement. Scanning electron microscope analysis is utilized to study the surface modifications of laser-irradiated Cu samples and reveals the formation of islands, craters, cones, and droplets. The finer-scale surface structures are grown in case of magnetic. It is also revealed Texc and ne play a substantial part in the growth of surface structures on Cu-alloy.
The Ethics of Countering Digital Propaganda
Authors: Bjola Corneliu 
Published: August 2018

AbstractHow can a state react to being a target of disinformation activities by another state without losing the moral ground that it seeks to protect? This essay argues that the concept of moral authority offers an original framework for addressing this dilemma. As a power resource, moral authority enables an actor to have its arguments treated with priority by others and to build support for its actions, but only as long as its behavior does not deviate from certain moral expectations. To develop moral authority, an actor engaged in combating digital propaganda must cultivate six normative attributes:truthfulnessandprudencefor demonstrating the nature of the harmful effects of disinformation;accountability,integrity, andeffectivenessfor establishing the normative standing of the actor to engage in counter-intervention; andresponsibilityfor confirming the proportionality of the response.
Ending Atrocity Crimes: The False Promise of Fatalism
Authors: Bellamy Alex J. 
Published: August 2018

AbstractHow should the international community respond when states commit atrocity crimes against sections of their own population? In practice, international responses are rarely timely or decisive. To make matters worse, half-hearted or self-interested interventions can prolong crises and contribute to the growing toll of casualties. Recognizing these brutal realities, it is tempting to adopt the fatalist view that the best that can be done is to minimize harm by letting the state win, allowing the status quo power structure to persist. Indeed, this is how many commentators and states have responded to the tide of human misery in Syria. Could a policy of letting the state perpetrator prevail be a viable alternative to other options, including military intervention? This essay suggests not. It explains the logic behind the fatalist approach and shows that problems of recurrence, precedence, and rights mean that such an approach cannot offer a plausible alternative to measures designed to resist and increase the costs of committing atrocity crimes.
Using spatial analysis to examine best placement of electronic benefit transfer services at farmers’ markets in Honolulu County, Hawaii, USA
Authors: Buchthal O Vanessa , Wolff Grace , Kittinger Daniela , Schaeffner Danielle , Nelson-Hurwitz Denise C 
Published: August 2018

AbstractObjectiveFarmers’ market interventions are a popular strategy for addressing chronic disease disparities in low-income neighbourhoods. With limited resources, strategic targeting of interventions is critical. The present study used spatial analysis to identify where market interventions have the greatest impact on healthy food access within a geographic region.DesignAll farmers’ markets in a mixed urban/rural county were mapped and those that accepted Supplemental Nutrition Assistance Program (SNAP) electronic benefit transfer (EBT) cards identified. Households were grouped into small neighbourhoods and mapped. The area of ‘reasonable access’ around each market (walking distance (0·8 km; 0·5mile) in urban areas, driving distance (15 min) in rural areas) was calculated using spatial analysis. The percentage of county low-income households within a market’s access area, and the percentage of county SNAP-participating households within an EBT-accepting market’s access area, were calculated. The ten neighbourhoods with the most low-income households and with the most SNAP-participating households were then identified, their access areas calculated and mapped, and those lacking access identified. County-level gains resulting from improving market accessibility in these areas were calculated.SubjectsNone.SettingHonolulu County, Hawaii, USA.ResultsOnly 44 % of SNAP-participating households had EBT-market access. Six of the ten highest SNAP-participant neighbourhoods lacked access. Improving access for these neighbourhoods increased county-level access by 23 %. Market access for low-income households was 74 %. Adding markets to these low-income neighbourhoods without market access increased county-level access by 4 %.ConclusionsGeographic identification of market access demographics, and strategic targeting of EBT interventions, could improve regional access to healthy foods.