bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of prenatal diagnosis of abnormally invasive placenta on maternal outcome: systematic review and meta‐analysis
Authors: Buca D. , Liberati M. , Calì G. , Forlani F. , Caisutti C. , Flacco M. E. , Manzoli L. , Familiari A. , Scambia G. , D'Antonio F. 
Published: April 2018

ABSTRACTObjectiveTo ascertain the impact of prenatal diagnosis on surgical outcome of women affected by abnormally invasive placenta (AIP).MethodsMEDLINE, EMBASE, CINAHL and Cochrane databases were searched. Observed outcomes included: gestational age at birth (weeks), amount of blood loss (L), units of red blood cells (RBC), platelets (PLT) and fresh frozen plasma (FFP) transfused, length of stay in hospital and the intensive care unit (ICU) (days), urinary tract injury and infection. Only studies reporting the occurrence of any of the explored outcomes in women with a prenatal compared with an intrapartum diagnosis of AIP were considered eligible for inclusion. Random‐effect head‐to‐head meta‐analyses were used to analyze the data.ResultsThirteen studies were included. Women with a prenatal diagnosis of AIP had less blood loss during surgery (mean difference (MD), −0.87; 95% CI, −1.5 to −0.23), had fewer units of RBC (MD, −1.45; 95% CI, −2.9 to −0.04) and FFP (MD, −1.73; 95% CI, −3.3 to −0.2) transfused, and delivered earlier (MD, 1.33 weeks; 95% CI, −2.23 to −0.43) compared with those with an intrapartum diagnosis. The risk of admission to an ICU and length of in‐hospital and in‐ICU stay were not different between the groups. Prenatal diagnosis of AIP was associated with a higher risk of urinary‐tract injury (odds ratio, 2.5; 95% CI, 1.3–4.6), mainly due to the higher prevalence of placenta percreta in the group with AIP diagnosed prenatally.ConclusionPrenatal diagnosis of AIP is associated with reduced hemorrhagic morbidity compared with cases in which such anomalies are detected at delivery. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.
Strategies to improve tumor penetration of nanomedicines through nanoparticle design
Authors: Zhang Ya‐Ru , Lin Run , Li Hong‐Jun , He Wei‐ling , Du Jin‐Zhi , Wang Jun 
Published: April 2018

Nanoparticles (NPs) have emerged as an effective means to deliver therapeutic drugs for cancer treatment, as they can preferentially accumulate at tumor site through the enhanced permeability and retention effect. Various forms of NPs including liposomes, polymeric micelles, and inorganic particles have been used for therapeutic applications. However, the therapeutic benefits of nanomedicines are suboptimal. Although many possible reasons may account for the compromised therapeutic efficacy, the inefficient tumor penetration can be a vital obstacle. Tumor develops characteristic pathological environment, such as abnormal vasculature, elevated interstitial fluid pressure, and dense extracellular matrix, which intrinsically hinder the transport of nanomedicines in the tumor parenchyma. The physicochemical properties of the NPs such as size, shape, and surface charge have profound effect on tumor penetration. In this review, we will highlight the factors that affect the transport of NPs in solid tumor, and then elaborate on designing strategies to improve NPs' penetration and uniform distribution inside the tumor interstitium.This article is categorized under:

Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Cover Image, Volume 10, Issue 3
Authors: Miao Xiaoqing , Yang Wuwei , Feng Tao , Lin Jing , Huang Peng 
Published: April 2018

The cover image, by Xiaoqing Miao et al., is based on the Advanced Review Drug nanocrystals for cancer therapy, DOI: 10.1002/wnan.1499.
image
The role of the Human Metabolome Database in inborn errors of metabolism
Authors: Mandal Rupasri , Chamot Danuta , Wishart David S. 
Published: April 2018

AbstractMetabolomics holds considerable promise to advance our understanding of human disease, including our understanding of inborn errors of metabolism (IEM). The application of metabolomics in IEM research has already led to the discovery of several novel IEMs and the identification of novel IEM biomarkers. However, with hundreds of known IEMs and more than 700 associated IEM metabolites, it is becoming increasingly challenging for clinical researchers to keep track of IEMs, their associated metabolites, and their corresponding metabolic mechanisms. Furthermore, when using metabolomics to assist in IEM biomarker discovery or even in IEM diagnosis, it is becoming much more difficult to properly identify metabolites from the complex NMR and MS spectra collected from IEM patients. To that end, comprehensive, open access metabolite databases that provide up‐to‐date referential information about metabolites, metabolic pathways, normal/abnormal metabolite concentrations, and reference NMR or MS spectra for compound identification are essential. Over the last few years, a number of compound databases, including the Human Metabolome Database (HMDB), have been developed to address these challenges. First described in 2007, the HMDB is now the world's largest and most comprehensive metabolomic resource for human metabolic studies. The latest release of the HMDB contains 114,100 metabolite entries (with 247 being relevant to IEMs), thousands of metabolite concentrations (with 600 being relevant to IEMs), and ~33,000 metabolic and disease‐associated pathways (with 202 being relevant to IEMs). Here we provide a summary of the HMDB and offer some guidance on how it can be used in metabolomic studies of IEMs.
Molecular biology and gene therapy for glycogen storage disease type Ib
Authors: Chou Janice Y. , Cho Jun‐Ho , Kim Goo‐Young , Mansfield Brian C. 
Published: April 2018

AbstractGlycogen storage disease type Ib (GSD‐Ib) is caused by a deficiency in the ubiquitously expressed glucose‐6‐phosphate (G6P) transporter (G6PT or SLC37A4). The primary function of G6PT is to translocate G6P from the cytoplasm into the lumen of the endoplasmic reticulum (ER). Inside the ER, G6P is hydrolyzed to glucose and phosphate by either the liver/kidney/intestine‐restricted glucose‐6‐phosphatase‐α (G6Pase‐α) or the ubiquitously expressed G6Pase‐β. A deficiency in G6Pase‐α causes GSD type Ia (GSD‐Ia) and a deficiency in G6Pase‐β causes GSD‐I‐related syndrome (GSD‐Irs). In gluconeogenic organs, functional coupling of G6PT and G6Pase‐α is required to maintain interprandial blood glucose homeostasis. In myeloid tissues, functional coupling of G6PT and G6Pase‐β is required to maintain neutrophil homeostasis. Accordingly, GSD‐Ib is a metabolic and immune disorder, manifesting impaired glucose homeostasis, neutropenia, and neutrophil dysfunction. A G6pt knockout mouse model is being exploited to delineate the pathophysiology of GSD‐Ib and develop new clinical treatment options, including gene therapy. The safety and efficacy of several G6PT‐expressing recombinant adeno‐associated virus pseudotype 2/8 vectors have been examined in murine GSD‐Ib. The results demonstrate that the liver‐directed gene transfer and expression safely corrects metabolic abnormalities and prevents hepatocellular adenoma (HCA) development. However, a second vector system may be required to correct myeloid and renal dysfunction in GSD‐Ib. These findings are paving the way to a safe and efficacious gene therapy for entering clinical trials.
A&nbsp;multiple-perspective approach for the assessment and learning of ultrasound skills
Authors: Tolsgaard Martin Grønnebæk 
Published: April 2018

Ultrasound has become a core skill in many specialties. We evaluated the learning and assessment of ultrasound skills in Obstetrics-Gynaecology in a series of eight studies. In the clinical setting, we found that trainees as well as experienced clinicians struggle with technical aspects of performance such as image optimization. We examined how to improve these aspects of performance in the simulated setting by determining mastery learning levels and exploring learning curves for novices. We then examined how to improve the efficiency of training as well as transfer of learning through the use of dyad practice as compared with single practice. We found that the use of simulation-based training focusing on technical aspects of performance in addition to clinical training led to sustained improvements in performance after two months of clinical training in all aspects of performance. In addition, we found an interaction effect between initial simulation-based training and subsequent clinical training on trainees’ need for supervision. These findings suggest that simulation-based training can work as preparation for future learning rather than merely as added learning. Finally, we found that the use of simulation-based initial training led to a large decrease in patients’ discomfort, improvements in their perceived safety and confidence in their ultrasound operator. However, simulation-based training comes at a cost and in the final study we developed a model for conducting cost-effectiveness studies and provided data from an example study on how to link training costs with quality of care.
On the learning machine with compensatory aggregation based neurons in quaternionic domain
Authors: Kumar Sushil , Tripathi Bipin Kumar 
Published: April 2018

Abstract
The nonlinear spatial grouping process of synapses is one of the fascinating methodologies for neuro-computing researchers to achieve the computational power of a neuron. Generally, researchers use neuron models that are based on summation (linear), product (linear) or radial basis (nonlinear) aggregation for the processing of synapses, to construct multi-layered feed-forward neural networks, but all these neuron models and their corresponding neural networks have their advantages or disadvantages. The multi-layered network generally uses for accomplishing the global approximation of input–output mapping but sometimes getting stuck into local minima, while the nonlinear radial basis function (RBF) network is based on exponentially decaying that uses for local approximation to input–output mapping. Their advantages and disadvantages motivated to design two new artificial neuron models based on compensatory aggregation functions in the quaternionic domain. The net internal potentials of these neuron models are developed with the compositions of basic summation (linear) and radial basis (nonlinear) operations on quaternionic-valued input signals. The neuron models based on these aggregation functions ensure faster convergence, better training, and prediction accuracy. The learning and generalization capabilities of these neurons are verified through various three-dimensional transformations and time series predictions as benchmark problems.
Highlights Two new CSU and CPU neuron models for quaternionic signals are proposed. Net potentials based on the compositions of summation and radial basis functions. The nonlinear grouping of synapses achieve the computational power of proposed neurons. The neuron models ensure faster convergence, better training and prediction accuracy. The learning and generalization capabilities of CSU/CPU are verified by various benchmark problems.
Science in The Children's Encyclopedia and its appropriation in the twentieth century in Latin America
Authors: DE OLIVEIRA BERNARDO JEFFERSON 
Published: April 2018

AbstractIn the early twentieth century, encyclopedias addressed to children and youths became special reference works concerning science and technology education. In search of greater comprehension of this historical process, I analyse The Children's Encyclopedia’s representation of science and technology, and how it was re-edited by the North American publishing company that bought its copyrights and promoted its circulation in several countries. Furthermore, I examine how its contents were appropriated in its translations into Portuguese and Spanish, which circulated in Latin America in the first half of the twentieth century. The comparison between the different versions reveals that the writings of science and technology are practically the same, with significant changes only in literature and in the approach of historical and geographical themes. I then argue that, even keeping the scientific contents virtually unchanged, these versions of the encyclopedia gave it a new meaning, because of the contexts in which they circulated. Finally, I show how the appropriations of the encyclopedia contributed to the promotion of scientific values and technological innovation as the core development and as a model of civilization for South American nations.
Colorectal cancers survivors’ adherence to lifestyle recommendations and cross-sectional associations with health-related quality of life
Authors: Breedveld-Peters Jose J. L. , Koole Janna L. , Müller-Schulte Eloise , van der Linden Bernadette W. A. , Windhausen Cherelle , Bours Martijn J. L. , van Roekel Eline H. , Weijenberg Matty P. 
Published: April 2018

AbstractThe lifestyle recommendations of the World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) are primarily intended for cancer prevention. In the absence of specific recommendations for cancer survivors, we investigated adherence of colorectal cancer (CRC) survivors to the WCRF/AICR lifestyle recommendations and associations with health-related quality of life (HRQoL). The cross-sectional part of the Energy for life after ColoRectal cancer (EnCoRe) study was conducted in 155 CRC survivors (stage I-III), 2–10 years post diagnosis. Dietary intake, physical activity and general body fatness were measured by 7-d food diaries, by questionnaires and accelerometers and BMI, respectively. Adherence to each of the ten WCRF/AICR recommendations was scored as 0 (no/low adherence), 0·5 (moderate adherence) or 1 point (complete adherence), and summed into an overall adherence score (range: 0–10). HRQoL, disability and distress were assessed by validated questionnaires. Associations of the overall WCRF/AICR adherence score with HRQoL outcomes were analysed by confounder-adjusted linear regression. The mean adherence score was 5·1 (sd1·4, range: 1·5–8·5). In confounder-adjusted models, a higher adherence score was significantly associated with the HRQoL dimension better physical functioning (βper 1 point difference in score: 2·6; 95 % CI 0·2, 5·1) and with less fatigue (β: −3·3; 95 % CI −6·4, −0·1). In conclusion, higher adherence of CRC survivors to WCRF/AICR lifestyle recommendations for cancer prevention was associated with better physical functioning and with less fatigue. This study adds to the limited knowledge on adherence to lifestyle behaviours in CRC survivors and relationships with quality of life. Prospective studies are needed to investigate longitudinal associations.
Mass transport deposits overprinted by contractional tectonics: a case study from the southern Apennines of Italy
Authors: PALLADINO GIUSEPPE , PROSSER GIACOMO , BENTIVENGA MARIO , ALSOP G. IAN 
Published: April 2018

AbstractMass transport deposits (MTDs), created by gravity-driven deformation of unlithified sediments, and tectonic mélanges produced by contractional deformation are characterized by a similar chaotic appearance. It follows that distinguishing structures formed by soft-sediment deformation during mass transport from those produced by contractional tectonics can be problematic. In fact, deformation occurring along detachment levels may completely obliterate the original sedimentary fabric. Although a number of advances have been made during recent decades, field criteria for discriminating structures within MTDs that are overprinted by later regional contraction are not readily applicable to all the exposed examples. We address some of these general issues through a detailed case study of the Monte Facito Formation in Italy. This Triassic unit was formed during the Africa–Europe continental separation and, since the Miocene, has been involved in contractional deformation during the construction of the Apennines. The Monte Facito Formation consists of a series of stratigraphically coherent units, separated by chaotic and often deformed intervals, whose origin has been previously attributed to either tectonic or sedimentary processes. An example is provided by a characteristic pebbly mudstone (or ‘paraconglomerate’) which has been interpreted as either a Triassic gravity-flow deposit, or alternatively, as a product of shearing along regional contractional detachments during the Miocene. This detailed field-based study allows us to recognize structures related to the depositional processes that created these chaotic intervals, and which can therefore be interpreted as MTDs. We also discriminate structures connected to later contractional tectonics that locally produced intense reworking of the MTDs.
Divine persons as relationalqua-objects
Authors: KOONS ROBERT C. 
Published: April 2018

AbstractIs the Christian doctrine of the Trinity consistent with a very strong version of the thesis of divine simplicity? Yes, so long as the simple divine nature is arelationalnature, a nature that could be characterized in terms of such relations as knowing and loving. This divine nature functions simultaneously as agent, patient, and action: as knower, known and knowledge, and lover, beloved, and love. I will draw on work onqua-objects by Kit Fine and Nicholas Asher and on my own account of relational facts to elucidate this model more fully.
Gastroenteritis outbreak at a health function caused by an emerging recombinant strain of Norovirus GII.P16/GII.4 Sydney 2012, Australia
Authors: Jones B. J. , Flint J. , Collins J. , White P. A. , Lun J. H. , Durrheim D. N. 
Published: April 2018

AbstractAn emerging recombinant norovirus GII.P16/GII.4 Sydney 2012 strain caused a gastroenteritis outbreak amongst attendees at a large health function in regional New South Wales, Australia. This was the third outbreak caused by the recombinant GII.P16/GII.4 Sydney 2012 strain in this region in 2017, which appears to be emerging as a common strain in the Hunter New England region.
Quantitative assessment of the association between IL-10 -592 A/C polymorphism and Kawasaki disease risk in Chinese population: evidence from a meta-analysis
Authors: Jin Xiaochun , Yin Shuzhou , Zhang Youtao , Chen Xu 
Published: April 2018

AbstractBackgroundIL-10, as a proinflammatory and anti-inflammatory cytokine, has been thought to have an important role in the development of Kawasaki disease. Variation in theIL-10gene might lead to altered protein production, which may result in Kawasaki disease. Several studies have been performed to investigate theIL-10-592 A/C polymorphism and Kawasaki disease risk. Unfortunately, the results of previous studies were inconsistent. Therefore, we performed a meta-analysis to derive a more precise estimation of the association between theIL-10-592 A/C polymorphism and Kawasaki disease risk.MethodThe association between theIL-10-592 A/C polymorphism and Kawasaki disease risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Six studies were enrolled in the present meta-analysis.ResultsOverall, no significant association betweenIL-10-592 A/C polymorphism and Kawasaki disease risk was found under allele contrast (A versus C: OR=0.95, 95% CI=0.77–1.18, p=0.668), homozygote comparison (AA versus CC: OR=0.86, 95% CI=0.56–1.31, p=0.475), heterozygote comparison (CA versus CC: OR=0.88, 95% CI=0.65–1.19, p=0.479), recessive genetic model (AA versus CA/CC: OR=0.96, 95% CI=0.73–1.28, p=0.801), or dominant genetic model (AA/CA versus CC: OR=0.85, 95% CI=0.64–1.13, p=0.275).ConclusionsWe conclude thatIL-10-592 A/C polymorphism was not associated with Kawasaki disease risk in the Chinese population. However, more primary large-scale and well-designed studies are still required to further evaluate the interaction ofIL-10-592 A/C polymorphism with Kawasaki disease risk.
Correlates of fruit and vegetable intake among parents and adolescents: findings from the Family Life, Activity, Sun, Health, and Eating (FLASHE) study
Authors: Parks Courtney A , Blaser Casey , Smith Teresa M , Calloway Eric E , Oh April Y , Dwyer Laura A , Liu Benmai , Nebeling Linda C , Yaroch Amy L 
Published: April 2018

AbstractObjectiveThe present study aimed to examine the correlates of fruit and vegetable intake (FVI) separately among parents and their adolescents.DesignCross-sectional surveys.SettingOnline survey.SubjectsParents and adolescents completed the Family Life, Activity, Sun, Health, and Eating (FLASHE) survey through the National Cancer Institute. The survey assessed daily intake frequencies of food/beverage groups, psychosocial, parenting and sociodemographic factors. Generalized linear models were run for both parents and adolescents, for a total of six models (three each): (i) sociodemographic characteristics; (ii) psychosocial factors; (iii) parent/caregiver factors.ResultsParent participants (n 1542) were predominantly 35–59 years old (86 %), female (73 %), non-Hispanic White (71 %) or non-Hispanic Black (17 %), with household income <$US 100 000 (79 %). Adolescents (n 805) were aged 12–14 years (50 %), non-Hispanic White (66 %) and non-Hispanic Black (15 %). Parents consumed 2·9 cups fruits and vegetables (F&V) daily, while adolescents consumed 2·2 cups daily. Educational attainment (higher education had greater FVI) and sex (men consumed more than women; all P<0·001) were significant FVI predictors. Parents with greater autonomous and controlled motivation, self-efficacy and preferences for fruit reported higher FVI (all P<0·001). Similarly, adolescents with greater autonomous and controlled motivation, self-efficacy and knowledge reported higher FVI (all P<0·001). Parenting factors of importance were co-deciding how many F&V teens should have, rules, having F&V in the home and cooking meals from scratch (all P<0·05).ConclusionsFindings suggest factors that impact FVI among parents and their adolescent(s), which highlight the importance of the role of parent behaviour and can inform tailored approaches for increasing FVI in various settings.
Plastic and metal additive manufacturing technologies for microwave passive components up toKaband
Authors: Sence Johann , Feuray William , Périgaud Aurélien , Tantot Olivier , Delhote Nicolas , Bila Stéphane , Verdeyme Serge , Pejoine Jean-Baptiste , Gramond René-Philippe 
Published: April 2018

AbstractThis paper illustrates the different possibilities given by additive manufacturing technologies for the creation of passive microwave hardware. The paper more specifically highlights a prototyping scheme where the 3D-printed plastic parts can be used as initial proofs of concept before considering more advanced 3D-printed parts (metal parts, for instance). First, a characterization campaign has been made on common plastics used by a 3D printer using the fused deposition modeling and material jetting (Polyjet©) technologies. The impact of the manufacturing strategy (high-speed or high-accuracy) on the part roughness, as well as on the dielectric material permittivity and loss tangent, has been specifically studied at 10 and 16 GHz. Based on a specifically optimized and deeply explained characterization method, the conductivity of a coating based on silver paint has also been characterized on such plastic parts at 10 and 40 GHz. These plastic materials and coating have been used for the creation of quasi-elliptic and tuning-free bandpass filters centered at 6 and 12 GHz and compared with a similar filter made of stainless steel by selective laser melting. Finally, a compact rectangularTE10to circularTE01mode converter also undergoes one prototyping step out of plastic before moving to an advanced part made out of stainless steel. This mode converter, which is made in a single part, is designed to operate from 28 to 36 GHz as a tuning-free final demonstrator.