bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of potassium sorbate (E‐202) and the antifungal PgAFP protein on Aspergillus carbonarius growth and ochratoxin A production in raisin simulating media
Authors: Fodil Sihem , Delgado Josué , Varvaro Leonardo , Yaseen Thaer , Rodríguez Alicia 
Published: May 2018

AbstractBACKGROUNDOchratoxin A (OTA) is a mycotoxin produced by several species of Aspergillus and Penicillium fungi. The presence of OTA in raisins is mainly related to black Aspergillus spp. contamination. This toxin poses risks to human and animal health due to its high toxicity and carcinogenicity. New strategies to avoid the risk associated with OTA are therefore necessary.RESULTSA comparison was made between the effects of the antifungal protein PgAFP and potassium sorbate (E‐202) on the growth of Aspergillus carbonarius, biosynthetic‐ and stress‐related gene expression and its OTA production at two water activity (aw) levels, 0.95 and 0.93 aw. The results showed that PgAFP successfully controlled OTA production, whereas E‐202, despite being able to reduce Aspergillus carbonarius growth, caused a significant increase in OTA production by the fungus.CONCLUSIONPgAFP protein, a biological compound with an antifungal activity, is safer to use than E‐202 and may be proposed as a food preservative and a useful strategy to control ochratoxigenic A. carbonarius in raisins. © 2018 Society of Chemical Industry
Fingerprints of acacia aging treatments by barrels or chips based on volatile profile, sensorial properties, and multivariate analysis
Authors: Alañón M Elena , Marchante Lourdes , Alarcón Marina , Díaz‐Maroto Ignacio J , Pérez‐Coello Soledad , Díaz‐Maroto María Consuelo 
Published: May 2018

AbstractBACKGROUNDDespite the acceptance of the use of chips as an alternative enological practice to traditional barrels, there is substantial interest in looking for parameters that enable the aging technique to be identified. In the present study, the volatile compound composition and sensorial characteristics of wines aged with chips and barrels of acacia wood were monitored with the aim of finding fingerprints that could be used to discriminate between the two types of aging.RESULTSPrincipal component analysis (PCA) calculated from chemical outputs permitted the two aging techniques to be distinguished. After 4 months of aging in barrels, concentrations of vanillin, ferulic acid, syringaldehyde, and furfural decreased considerably due to the higher oxidation produced by the acacia wood's porosity. This fact made it more difficult to discriminate between those wines aged in barrels for the longest times. On the other hand, PCA applied to sensorial data allowed a clear differentiation between wines aged in acacia barrels for longer periods and those macerated with chips, due to the notable presence of sensory attributes described as acacia wood, nutty, honeyed, and toasty.CONCLUSIONChemical and sensorial data can be regarded as complementary methods to obtain fingerprints that enable differentiation between the two different aging techniques by means of acacia wood. © 2018 Society of Chemical Industry
Opioid prescribing practices in patients undergoing surgery for oral cavity cancer
Authors: Pang John , Tringale Kathryn R. , Tapia Viridiana J. , Panuganti Bharat A. , Qualliotine Jesse R. , Jafari Aria , Haft Sunny J. , Friedman Lawrence S. , Furnish Timothy , Brumund Kevin T. , Califano Joseph A. , Coffey Charles S. 
Published: May 2018

ObjectivesOpioids have been overprescribed after general and orthopedic surgeries, but prescribing patterns have not been reported for head and neck surgery. The objectives of this retrospective review are to describe postoperative opioid prescriptions after oral cancer surgery and determine which patients receive higher amounts.MethodsA single institution retrospective review was performed for 81 adults with oral cavity tumors undergoing surgery. Opioid prescriptions upon discharge were reported in daily oral morphine equivalents (OME). High opioids were defined as > 90 mg daily and > 200 mg total, commensurate with U.S. Center for Disease Control and Prevention and state guidelines. Multivariable logistic regression was performed to investigate factors associated with high opioids.ResultsThe median number of doses dispensed was 30 (interquartile range [IQR] 30–45; range 3–120). The median daily dose was 30 mg (IQR 20–45 mg; range 15–240 mg). Five patients (6%) received higher than the recommended daily dose. The median total dispensed amount was 225 mg (IQR 150–250 mg; range 15–1200 mg). Fifty‐one (63%) received greater than the recommended total dose. On multivariable logistic regression, advanced tumor stage (odds ratio [OR] 11.5; 95% confidence interval [CI] 1.2–109.4; P = 0.034) and inpatient pain scores (OR 1.3 per 1‐unit increase; 95% CI 1.0–1.7; P = 0.039) were associated with receiving high total opioids after surgery.ConclusionThe majority of patients received greater than the recommended 200 mg total OME. Advanced stage and higher inpatient pain scores were associated with receiving more opioids for discharge. Consensus‐driven analgesic plans are needed to reduce excess opioids after discharge following head and neck surgery.Level of Evidence4. Laryngoscope, 128:2361–2366, 2018
Otopathologic evaluation of temporalis fascia grafts following successful tympanoplasty in humans
Authors: Trakimas Danielle R. , Ishai Reuven , Ghanad Iman , Black Nicole L. , Kozin Elliott D. , Cheng Jeffrey Tao , Remenschneider Aaron K. 
Published: May 2018

ObjectiveTemporalis fascia is a commonly used graft material in tympanoplasty; however, little is known about how the histological structure of fascia remodels postimplantation. Herein, we aim to quantify the pre‐ and postoperative microstructure of temporalis fascia and compare histological findings to the native tympanic membrane (TM).MethodsTemporal bone specimens having undergone successful subtotal or total drum replacement using temporalis fascia were identified (n = 3). Surgically prepared preimplantation temporalis fascia (PreTF, n = 4) and normal TMs (n = 5) were used as controls. Multiple measurements of thickness of PreTF and of normal and fascia reconstructed TMs at the mesotympanum and hypotympanum were obtained. Collagen fiber patterns of normal and reconstructed TMs were histologically described.ResultsIn cases of fascia tympanoplasty, the mean time of surgery to death was 16 years (range 8–28 years). All cases contained an aerated middle ear without residual perforation. There was no significant difference between the thickness of PreTF and fascia of reconstructed TMs (234.9 ± 144.9 μm vs. 162.9 ± 71.9 μm, P = 0.1). The lamina propria and total thicknesses of controls (59.8 ± 39.3 μm and 83.7 ± 42.4 μm, respectively) were thinner than the PreTF and fascia‐reconstructed TMs, respectively, in all cases (P ≤ 0.001, P ≤ 0.001). Reconstructed TMs contained a thick, longitudinal fiber structure that was qualitatively similar to PreTF.ConclusionBased on human temporal bone specimens, temporalis fascia does not significantly remodel, change thickness, or change fibrous structure following successful tympanoplasty. Results have implications for selection and surgical preparation of graft materials in TM reconstruction.Level of Evidence4. Laryngoscope, 128:E351–E358, 2018
Treatment delays in laryngeal squamous cell carcinoma: A national cancer database analysis
Authors: Morse Elliot , Fujiwara Rance J.T. , Judson Benjamin , Mehra Saral 
Published: May 2018

ObjectiveTo characterize treatment delays in laryngeal cancer and associate delays with patient, tumor, and treatment factors and with overall survival.MethodsWe identified 33,819 adults with laryngeal squamous cell carcinoma (LSCC) in the National Cancer Database from 2004 to 2013. We calculated durations of diagnosis‐to‐treatment initiation, surgery‐to‐adjuvant treatment, radiotherapy duration, total treatment package, and diagnosis‐to‐treatment end intervals. Delays were associated with patient, tumor, and treatment characteristics via multivariable logistic regression and with overall survival by Cox proportional hazards regression.ResultsMedian durations of diagnosis‐to‐treatment initiation, surgery‐to‐radiation initiation, radiation treatment, total treatment package, and diagnosis‐to‐treatment end were 28, 42, 48, 91, and 107 days in surgical patients; median durations of diagnosis‐to‐treatment initiation, radiation treatment, and diagnosis‐to‐treatment end were 33, 50, and 85 days in nonsurgical patients. Race and insurance status were linked to delays in most intervals. Academic and high‐volume facilities had less delayed radiation treatment but increased delays in most other intervals. Delayed surgery‐to‐radiation and total treatment package intervals were associated with overall survival in surgical patients (hazard ratio [HR] = 1.15 [1.03–1.29], P = 0.015; HR = 1.16 [1.02–1.31], P = 0.025). Diagnosis‐to‐treatment initiation and diagnosis‐to‐treatment end intervals were associated with overall survival in nonsurgical patients (HR = 1.08 [1.02–1.14], P = 0.007; HR = 1.09 [1.03–1.16], P = 0.003, respectively) but not in surgical patients (HR = 0.96 [0.87–1.06] P = 0.440; HR = 1.13 [0.99–1.29], P = 0.062). Radiation delays were associated with overall survival in surgical and nonsurgical patients (HR = 1.21 [1.09–1.36], P = 0.001; HR = 1.37 [1.30–1.44], P < 0.001).ConclusionThese durations can serve as national benchmarks. Delays could be considered quality indicators in LSCC.Level of Evidence2b Laryngoscope, 128:2751–2758, 2018
The effect of photodynamic therapy on pathogenic bacteria around peri‐implant sulcus and in the cavity between abutment and implant after healing phase: A prospective clinical study
Authors: Zhou Lin‐Yi , Shi Jun‐Yu , Zhu Yu , Qian Shu‐Jiao , Lai Hong‐Chang , Gu Ying‐Xin 
Published: May 2018

ObjectivesTo compare levels of pathogens from peri‐implant sulcus versus abutment screw cavities after photodynamic therapy.Material and MethodsTwenty patients were included. Photodynamic therapy (PDT) was applied both in sulcus and cavities after sampling following suprastructures loading, and repeated after 2 weeks. Two samples each containing four paper points were collected for each implant at baseline, 2 weeks, 3 months: (i) peri‐implant sulcus and (ii) abutment screw cavities. Seventy‐five percent ethanol was applied in another 20 patients as the control group in the same way. qPCR was used to quantify periodontal pathogens: Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus mutans.ResultsPDT showed a better bacterial reduction than ethanol. P. g. and F. n. were most frequently detected, while less for S. m. P. gingivalis’ proportion from both sites was significantly higher than the other two bacteria (P < 0.05), except for 2 weeks’ peri‐implant sulcus sample. Bacteria counts from abutment screw cavities were always less than those from peri‐implant sulcus and was significantly lower for total bacteria at 3 months (P < 0.05). Total bacterial from abutment screw cavities significantly reduced at 3 months compared to baseline (P < 0.05).ConclusionsPDT appears to be effective in bacterial reduction compared to ethanol and can reduce P. gingivalis with short time intervals, as well as decreasing total bacteria counts within abutment screw cavities in the long run, suggesting PDT an effective way sterilizing inner surface of oral implant suprastrutures. Lasers Surg. Med. 50:433–439, 2018. © 2018 Wiley Periodicals, Inc.
Elliptic complexes of first‐order cone operators: ideal boundary conditions
Authors: Krainer Thomas , Mendoza Gerardo A. 
Published: May 2018

AbstractThe purpose of this paper is to provide a detailed description of the spaces that can be specified as L2 domains for the operators of a first order elliptic complex on a compact manifold with conical singularities. This entails an analysis of the nature of the minimal domain and of a complementary space in the maximal domain of each of the operators. The key technical result is the nondegeneracy of a certain pairing of cohomology classes associated with the indicial complex. It is further proved that the set of choices of domains leading to Hilbert complexes in the sense of Brüning and Lesch form a variety, as well as a theorem establishing a necessary and sufficient condition for the operator in a given degree to map its maximal domain into the minimal domain of the next operator.
Upper bound for the ratios of eigenvalues of Schrödinger operators with nonnegative single‐barrier potentials
Authors: Ben Amara Jamel , Hedhly Jihed 
Published: May 2018

AbstractIn this paper we prove the optimal upper bound
urn:x-wiley:0025584X:media:mana201700164:mana201700164-math-0001for one‐dimensional Schrödinger operators with a nonnegative differentiable and single‐barrier potential , such that , where . In particular, if satisfies the additional condition , then for . For this result, we develop a new approach to study the monotonicity of the modified Prüfer angle function.
When opposites attract? Exploring the existence of complementarity in self‐brand congruence processes
Authors: Karampela Maria , Tregear Angela , Ansell Jonathan , Dunnett Susan 
Published: May 2018

AbstractIn the psychology of human interpersonal attraction, complementarity is a well‐recognized phenomenon, where individuals are attracted to partners with different but complementary traits to their own. Although scholarship in human–brand relations draws heavily from interpersonal attraction theory, preferred techniques for measuring self‐brand congruence tend to capture it in only one form: the similarity configuration, which expresses the extent to which brand traits essentially resemble or mirror a consumer's own. Hence, the aim of this study is to explore, for the first time, the existence of complementarity in self‐brand congruence. From a canonical correlation analysis of survey data in which respondents rated their own personality traits and those of their favorite brand, the existence of both similarity and complementarity configurations is indeed revealed. Based on this, the study then derives a measure of self‐brand congruence that captures both configurations, and tests its predictive power for a range of brand‐related outcomes. The new measure is found to perform well against existing measures of self‐brand congruence based purely on a similarity configuration, particularly for emotionally based brand‐related outcomes.
Hyaluronic Acid–Modified Porous Silicon Films for the Electrochemical Sensing of Bacterial Hyaluronidase
Authors: Tücking Katrin‐Stephanie , Vasani Roshan B. , Cavallaro Alex A. , Voelcker Nicolas H. , Schönherr Holger , Prieto‐Simon Beatriz 
Published: May 2018

AbstractThe development of enzyme‐responsive hyaluronic acid methacrylate (HYAMA)‐coated porous silicon (pSi) films and their application in electrochemical diagnostic devices for the in situ detection of the enzyme hyaluronidase (hyal), which is secreted by Staphylococcus aureus (S. aureus) bacteria, are reported. The approach relies on a HYAMA‐pSi electrode made of thermally hydrocarbonized pSi (pSi‐THC) that is impregnated with crosslinked HYAMA/polyethylene glycol diacrylate (PEGDA) hydrogels. The enzymatic degradation of HYAMA by bacterial hyal is monitored by differential pulse voltammetry (DPV) utilizing pSi‐THC as a working electrode and ferro/ferricyanide (FF) as external redox probe. The degradation of HYAMA results in reduced diffusion of the redox probe through the partially charged film, thereby enabling the detection of hyal by DPV. In addition to the determination of the concentration‐dependent response in NaOAc buffer (pH 5.2), the detection of hyal as indicator for the presence of S. aureus bacteria above a threshold level in bacterial supernatants and artificial wound fluid is highlighted.
Evolution of Chain Length Distribution and Microstructure of Macromolecules in Irreversible Copolymerization Proceeding with Segmental Exchange Investigated with a New Monte Carlo Algorithm
Authors: Szymanski Ryszard , Sosnowski Stanislaw 
Published: May 2018

AbstractA process of irreversible copolymerization with segmental exchange reactions is simulated using a Monte Carlo algorithm. The terminal (dyad) model is assumed for eight considered reactions: propagations and attacks of active centers on monomeric units in chains with subsequent chain scissions. It is established that microstructure of macromolecules at any given moment depends on the values of reaction rate constants and evolves from the beginning one, defined mainly by propagation rates, to the final one, determined by chain transfer rates. Dispersity and randomization degree of unit sequences in macromolecules can change nonmonotonically with progress of the process. Equilibration of the microstructure needs usually significantly longer time than needed for attaining the equilibrium chain lengths distribution. The proposed new Monte Carlo algorithm allows to more efficiently investigate the studied process.
Technical Note: Predicting dose distribution with replacing stopping power ratio for inter‐fractional motion and intra‐fractional motion during carbon ion radiotherapy with passive irradiation method for stage I lung cancer
Authors: Kubota Yoshiki , Sakai Makoto , Tashiro Mutsumi , Saitoh Jun‐ichi , Abe Takanori , Ohno Tatsuya , Nakano Takashi 
Published: May 2018

PurposeWe designed and evaluated a simple method for predicting the effects of intra‐fractional and/or inter‐fractional motion on dose distribution during carbon ion radiotherapy (CIRT) for solitary‐lesion stage I lung cancer.MethodsThe proposed method uses computed tomography (CT) images from treatment planning and intra‐tumoral and/or inter‐tumoral displacement. The predicted dose distribution (PDD) was calculated by replacing the current tumor region with the stopping power ratio (SPR) of the lung and replacing the moved tumor region with the SPR of the tumor. The actual dose distribution (ADD) was calculated without the replacement. Ten patients with solitary‐lesion stage I lung cancer were retrospectively studied to evaluate the prediction method's accuracy. Four PDDs for intra‐fractional motion (gate‐in, exhalation, gate‐out, inhalation phases during four‐dimensional CT) and two PDDs for inter‐fractional motion (CT images acquired 1–2 days before treatment) with bone‐ and tumor‐matching methods were compared with each of six ADDs on each CT scan. Percentages of the planning/clinical target volumes (PTV/CTV) receiving >95% of the prescribed dose (V95) and of minimum doses covering 95% of the PTV/CTV (D95) were compared with dose volume histogram parameters.ResultsThe maximum tumor displacements occurred in the superior–inferior direction, with intra‐fractional motion values of 3.75 and 8.97 mm for the superior and inferior directions, respectively, and inter‐fractional values of 9.61 and 4.10 mm. The maximum average error for PTV V95 regarding intra‐fractional motion was −0.43% for the gate‐out phase and −0.63% for the inhalation phase. There were no significant differences for these parameters (P = 0.541, P = 0.571). Average errors for PTV and CTV V95 with inter‐fractional motion with bone matching were 2.2% and 2.9%, respectively, with no significant differences (P = 0.387, P = 0.155).ConclusionsThe accuracy of the proposed method was good. Hence, it is feasible to use the proposed method during CIRT to predict dose distribution with respect to intra‐fractional motion and/or inter‐fractional motion of the tumor in patients with solitary‐lesion stage I lung cancer.
Model‐based reconstruction for simultaneous multislice and parallel imaging accelerated multishot diffusion tensor imaging
Authors: Dong Zijing , Dai Erpeng , Wang Fuyixue , Zhang Zhe , Ma Xiaodong , Yuan Chun , Guo Hua 
Published: May 2018

PurposeMultishot interleaved echo‐planar imaging (iEPI) can achieve higher image resolution than single‐shot EPI for diffusion tensor imaging (DTI), but its application is limited by the prolonged acquisition time. To reduce the acquisition time, a novel model‐based reconstruction for simultaneous multislice (SMS) and parallel imaging (PI) accelerated iEPI DTI is proposed.Materials and methodsDTI datasets acquired by iEPI with SMS and PI acceleration can be regarded as 3D k‐space data, which is undersampled along both the slice and phase encoding directions. Instead of reconstruction of individual diffusion‐weighted image, diffusion tensors are directly estimated by the joint reconstruction of undersampled 3D k‐space from all diffusion‐encoding directions using a model‐based formulation to exploit the correlation across different directions. DTI simulation and in vivo acquisition were used to demonstrate the superior performance of the proposed method.ResultsThe proposed method reduced the estimation errors and artifacts than traditional parallel imaging reconstruction in DTI simulation. In the in vivo DTI experiment, the acquisition time of 4‐shot iEPI was reduced from 11 min 7 s to 3 min 53 s with an acceleration factor of 4, and the image quality and precision of quantitative parameters were comparable with the fully sampled acquisition.ConclusionsThe proposed model‐based reconstruction for iEPI DTI with SMS and PI can achieve fourfold acceleration while maintaining high accuracy for tensor measurements.
Auditory exostosis: Exploring the daily life at an early sedentary population (Körtik Tepe, Turkey)
Authors: Koruyucu M. M. , Şahin F. S. , Delibaş D. , Erdal Ö. D. , Benz M. , Özkaya V. , Erdal Y. S. 
Published: May 2018

AbstractAuditory exostosis (AE) is a bony anomaly located on the tympanic portion of the temporal bone. Cold water, wind chill, and the effects of temperature are considered to be contributors to the development of AE. It is frequently encountered among surfers, lifeguards, whitewater kayakers, swimmers, and divers. Accordingly, there is a strong relationship between prolonged exposure to cold water and the frequency and grade of AE. For this reason, AE can be accepted as an occupational anomaly.In this study, AE from Körtik Tepe, Turkey, were analysed to understand the lifestyle of early hunter gatherer populations from Anatolia. One hundred twenty‐eight individuals and 174 temporal bones from Körtik Tepe were examined for the frequency and severity (graded) of AE. Forty‐five individuals (35.2%) have exostosis of various sizes. Half of 40 male individuals and 42.5% of females (n: 40) have AE with no statistically significant difference between the sexes. First observed in individuals 7 years of age, severity and frequency of AE increase with age. Besides increasing in frequency, the increase in size of AE suggest a continuous and prolonged exposure to cold water.The people of Körtik Tepe, which is surrounded by numerous freshwater sources, must have been subjected to cold water through activities such as bathing, cleaning, swimming, and playing in the water, as well as fishing. Our results suggest that the lifestyle of early sedentary people in Körtik Tepe was rather egalitarian with little or no gender differences and was closely connected to aquatic sources. Bioarchaeological data suggest that Körtik Tepe can be accepted as a community of hunter‐gatherer‐fishermen.