bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of visual function in Royal College of Surgeon rats using a depth perception visual cliff test
Authors: Tzameret Adi , Sher Ifat , Edelstain Victoria , Belkin Michael , Kalter-Leibovici Ofra , Solomon Arieh S. , Rotenstreich Ygal 
Published: January 2019

AbstractPreserving of vision is the main goal in vision research. The presented research evaluates the preservation of visual function in Royal College of Surgeon (RCS) rats using a depth perception test. Rats were placed on a stage with one side containing an illusory steep drop (“cliff”) and another side with a minimal drop (“table”). Latency of stage dismounting and the percentage of rats that set their first foot on the “cliff” side were determined. Nondystrophic Long–Evans (LE) rats were tested as control. Electroretinogram and histology analysis were used to determine retinal function and structure. Four-week-old RCS rats presented a significantly shorter mean latency to dismount the stage compared with 6-week-old rats (mean ± standard error, 13.7 ± 1.68 vs. 20.85 ± 6.5 s, P = 0.018). Longer latencies were recorded as rats aged, reaching 45.72 s in 15-week-old rats (P < 0.00001 compared with 4-week-old rats). All rats at the age of 4 weeks placed their first foot on the table side. By contrast, at the age of 8 weeks, 28.6% rats dismounted on the cliff side and at the age of 10 and 15 weeks, rats randomly dismounted the stage to either table or cliff side. LE rats dismounted the stage faster than 4-week-old RCS rats, but the difference was not statistically significant (7 ± 1.58 s, P = 0.057) and all LE rats dismounted on the table side. The latency to dismount the stage in RCS rats correlated with maximal electroretinogram b-wave under dark and light adaptation (Spearman’s rho test = −0.603 and −0.534, respectively, all P < 0.0001), outer nuclear layer thickness (Spearman’s rho test = −0.764, P = 0.002), and number of S- and M-cones (Spearman’s rho test = −0.763 [P = 0.002], and −0.733 [P = 0.004], respectively). The cliff avoidance test is an objective, quick, and readily available method for the determination of RCS rats’ visual function.
A Gender Gap in Party Congruence and Responsiveness?
Authors: Ferland Benjamin 
Published: January 2019

AbstractCongruence and responsiveness between the policy preferences of citizens and elites are considered key characteristics of democracy. Although these relationships between citizens and elites have been thoroughly examined, little attention has been devoted to differences in the representation of women and men in studies of congruence and responsiveness. Herein, I evaluate the presence of a gender gap both in terms of party congruence and party responsiveness with respect to the relationship between female and male supporters and the party they voted for. In addition, I examine whether the presence of elected women in parties decreases the gender gap in party congruence and responsiveness. My analyses of the data from the Comparative Study of Electoral Systems and several national elections studies indicate that parties are generally as close and as responsive to the preferences of male supporters as to those of female supporters on the left–right ideological scale. However, the presence of elected women in parties favors women's representation and may thus reduce inequality in gender representation.
Conservative Women in Germany and Japan: Chancellors versus Madonnas
Authors: Gaunder Alisa , Wiliarty Sarah 
Published: January 2019

AbstractDespite many similarities between them, the German Christian Democratic Union (CDU) and the Japanese Liberal Democratic Party (LDP) have represented women in parliament at different rates. This article argues that differences in party organization, electoral system rules, and left party strength interact to explain the varying levels of representation of conservative women in parliament. The CDU's corporatist structure allowed it to represent diverse interests and successfully respond to challenges for female support from the left. As a result of a weaker left party challenge and a classic catch-all party organization, the LDP's attempts to incorporate women have been less extensive and largely symbolic.
Should performance-based incentives be used to motivate health care providers? Views of health sector managers in Cambodia, China and Pakistan
Authors: Khan Mishal , Roychowdhury Imara , Meghani Ankita , Hashmani Farah , Borghi Josephine , Liverani Marco 
Published: January 2019

AbstractThis study qualitatively investigates what factors apart from or in addition to financial incentives can encourage better performance of frontline health care providers. We interviewed health sector managers in Pakistan, Cambodia and China, and they highlighted many potential limitations in the applicability of financial incentives in their contexts. There was a consistent view that providers are not always primarily driven by monetary rewards and that non-monetary rewards – such as recognition from direct supervisors and career development – could have a greater influence on performance. Managers also highlighted several challenges related to the design and implementation of performance management schemes: supervisors may not have performance information necessary to determine which agents to reward; when performance information is available, organisational culture may value other attributes such as social ties or years of experience; finally, concentration of power at higher levels of the health system can reduce supervisors’ ability to manage performance, rewards and accountability. Although health sector managers were enthusiastic about measures to improve performance of providers, our study indicated that specific social, cultural and health system factors may mean that non-monetary rewards and structural changes to support a more transparent and meritocratic working environment should also be considered.
Climate Change Suppresses Santa Ana Winds of Southern California and Sharpens Their Seasonality
Authors: Guzman‐Morales Janin , Gershunov Alexander 
Published: January 2019

AbstractWe downscale Santa Ana winds (SAWs) from eight global climate models (GCMs) and validate key aspects of their climatology over the historical period. We then assess SAW evolution and behavior through the 21st century, paying special attention to changes in their extreme occurrences. All GCMs project decreases in SAW activity, starting in the early 21st century, which are commensurate with decreases in the southwestward pressure gradient force that drives these winds. The trend is most pronounced in the early and late SAW season: fall and spring. It is mainly determined by changes in the frequency of SAW events, less so by changes in their intensity. The peak of the SAW season (November–December–January) is least affected by anthropogenic climate change in GCM projections.
Attribution of Global Soil Moisture Drying to Human Activities: A Quantitative Viewpoint
Authors: Gu Xihui , Zhang Qiang , Li Jianfeng , Singh Vijay P. , Liu Jianyu , Sun Peng , Cheng Changxiu 
Published: January 2019

AbstractAnthropogenic impacts on widespread global soil moisture (SM) drying in the root zone layer during 1948–2005 were evaluated based on the Global Land Data Assimilation System version 2 (GLDAS‐2) and global climate models from the Coupled Model Intercomparison Project Phase 5 using trend analysis and optimal fingerprint methods. Both methods show agreement that natural forcing alone cannot drive significant SM drying. There is a high probability (≥90%) that the anthropogenic climate change signal is detectable in global SM drying. Specifically, anthropogenic greenhouse gas forcing can lead to global SM drying by 2.1 × 10−3 m3/m3, which is comparable to the drying trend seen in Global Land Data Assimilation System version 2 (2.4 × 10−3 m3/m3) over the past 58 years. Global SM drying is expected to continue in the future, given continuous greenhouse gas emissions.
The First Concurrent Observations of Thermospheric Na Layers From Two Nearby Central Midlatitude Lidar Stations
Authors: Xun Yuchang , Yang Guotao , She Chiao‐Yao , Wang Jihong , Du Lifang , Yan Zhaoai , Yang Yong , Cheng Xuewu , Li Faquan 
Published: January 2019

AbstractIn 2011, Chu et al. reported the observation of neutral Fe layers reaching 155 km. Since then, there are five additional reports of layers extending above 130 km to as high as 170 km, none from central middle latitudes (35°–55°), a large atmospheric region of considerable importance. Here we report the first concurrent observations of thermospheric Na layers from two nearby lidar stations so located, Yanqing (40.5°N, 116.0°E) and Pingquan (41.0°N, 118.7°E). From one‐year data set, we found four such layers, including an unprecedented one reaching 200 km with highest density of 35 cm−3 and fastest descending rate. While the main Na layers were comparable, in three nights, these thermospheric layers were observed only in one station (Yanqing), suggesting that these layers often occur locally with a horizontal scale less than ~250 km. We tabulate, compare, and discuss the principle characteristics of all the reported thermospheric layers.
Atlantic Deep‐Sea Cherts Associated With Eocene Hyperthermal Events
Authors: Penman Donald E. , Keller Allison , D'haenens Simon , Kirtland Turner Sandra , Hull Pincelli M. 
Published: January 2019

AbstractChert, porcelainite, and other siliceous phases are exceptionally common in Atlantic sedimentary records of the early Eocene, but the origins of these facies remain enigmatic. The early Eocene was also the warmest interval of the entire Cenozoic Era, punctuated by numerous discrete warming events termed “hyperthermals,” the largest of which is termed the Paleocene‐Eocene Thermal Maximum (~56 Ma). Here we present new and published lithologic and carbon isotope records of silica‐bearing lower Eocene sediments and suggest a link between the ubiquitous Atlantic cherts of that time period and hyperthermal events. Our data demonstrate that many of these Atlantic siliceous horizons coincide with negative carbon isotope excursions (a hallmark of hyperthermal events), including a previously unrecognized record of the Paleocene‐Eocene Thermal Maximum in the South Atlantic. Hyperthermal‐associated silica burial appears to be focused in the western middle to high latitudes of both the North and South Atlantic, with no association between siliceous facies and hyperthermal events found in the Pacific. We also present a new model of the coupled carbon and silica cycles (LOSiCAR) to demonstrate that enhanced silicate weathering during these events would require a rapid increase in total marine silica burial. Model experiments that include previously suggested transient reversals in the pattern of deep‐ocean circulation during hyperthermals demonstrate that such a mechanism can explain the apparent focusing of elevated silica burial into the Atlantic. This combination—a silicate weathering feedback in response to global warming along with a circulation‐driven focusing of silica burial—represents a new mechanism for the formation of deep‐sea cherts in lower Eocene Atlantic sedimentary records and may be relevant to understanding chert formation in other intervals of Earth history.
Effects of Ionospheric Conductivity and Ground Conductance on Geomagnetically Induced Currents During Geomagnetic Storms: Case Studies at Low‐Latitude and Equatorial Regions
Authors: Espinosa Karen V. , Padilha Antonio L. , Alves Livia R. 
Published: January 2019

AbstractGeomagnetic field variations recorded by fluxgate magnetometers are used to evaluate geomagnetically induced currents (GICs) under the equatorial electrojet (EEJ) and South Atlantic Magnetic Anomaly (SAMA) during two geomagnetic storms in March and June 2015. Geomagnetic stations with information about the underground electrical conductivity structure and that can be approximated by unidimensional (1‐D) models for calculation of the geoelectric field are selected. GICs levels are estimated using a realistic local power grid model located in the central region of Brazil, artificially moved to the sites where the geomagnetic measurements are available. GIC magnitudes are not large during the storms, and a maximum amplitude of 3.8 A was estimated at an equatorial station positioned over high resistivity underground during the main phase of the June storm. Effects of the ionospheric currents over the measurement sites and of the conductivity distribution beneath these sites are also evaluated. It is observed that both (EEJ) and (SAMA) increase the GICs amplitudes, with the greatest effects associated with daytime (EEJ) currents. A cutoff frequency was identified for both the (EEJ) and (SAMA) so that signals with frequencies lower than 2 mHz (periods longer than 500 s) are not amplified by the ionospheric currents. In relation to the underlying conductivity structure, GIC magnitude is affected by variation of the surface impedance and the sampling rate of the geomagnetic field. In our case, differences in amplitude of the surface impedance at the Nyquist frequency control the relative effects of the ground conductance between the stations.
Structure of the Lithosphere Beneath the Barotse Basin, Western Zambia, From Magnetotelluric Data
Authors: Evans R. L. , Elsenbeck J. , Zhu J. , Abdelsalam M. G. , Sarafian E. , Mutamina D. , Chilongola F. , Atekwana E. A. , Jones A. G. 
Published: January 2019

AbstractA magnetotelluric survey in the Barotse Basin of western Zambia shows clear evidence for thinned lithosphere beneath an orogenic belt. The uppermost asthenosphere, at a depth of 60–70 km, is highly conductive, suggestive of the presence of a small amount of partial melt, despite the fact that there is no surface expression of volcanism in the region. Although the data support the presence of thicker cratonic lithosphere to the southeast of the basin, the lithospheric thickness is not well resolved and models show variations ranging from ~80 to 150 km in this region. Similarly variable is the conductivity of the mantle beneath the basin and immediately beneath the cratonic lithosphere to the southeast, although the conductivity is required to be elevated compared to normal lithospheric mantle. In a general sense, two classes of model are compatible with the magnetotelluric data: one with a moderately conductive mantle and one with more elevated conductivities. This latter class would be consistent with the impingement of a stringer of plume‐fed melt beneath the cratonic lithosphere, with the melt migrating upslope to thermally erode lithosphere beneath the orogenic belt that is overlain by the Barotse Basin. Such processes are potentially important for intraplate volcanism and also for development or propagation of rifting as lithosphere is thinned and weakened by melt. Both models show clear evidence for thinning of the lithosphere beneath the orogenic belt, consistent with elevated heat flow data in the region.
Parental and early life stage environments drive establishment of bacterial and dinoflagellate communities in a common coral
Authors: Epstein Hannah E , Torda Gergely , Munday Philip L , van Oppen Madeleine J H 
Published: January 2019

Abstract
The establishment of coral microbial communities in early developmental stages is fundamental to coral fitness, but its drivers are largely unknown, particularly for bacteria. Using an in situ reciprocal transplant experiment, we examined the influence of parental, planulation and early recruit environments on the microbiome of brooded offspring in the coral Pocillopora damicornis. 16S rRNA and ITS2 rDNA gene metabarcoding showed that bacterial and microalgal endosymbiont communities varied according to parental and planulation environments, but not with early recruit environment. Only a small number of bacterial strains were shared between offspring and their respective parents, revealing bacterial establishment as largely environmentally driven in very early life stages. Conversely, microalgal communities of recruits were highly similar to those of their respective parents, but also contained additional low abundance strains, suggesting both vertical transmission and novel (‘horizontal’) acquisition. Altogether, recruits harboured more variable microbiomes compared to their parents, indicating winnowing occurs as corals mature.
Chronic fluoxetine prevents fear memory generalization and enhances subsequent extinction by remodeling hippocampal dendritic spines and slowing down systems consolidation
Authors: Pedraza Lizeth K. , Sierra Rodrigo O. , Giachero Marcelo , Nunes-Souza Walquiria , Lotz Fernanda N. , de Oliveira Alvares Lucas 
Published: January 2019

AbstractFear memory overgeneralization contributes to the genesis and persistence of anxiety disorders and is a central hallmark in the pathophysiology of post-traumatic stress disorder (PTSD). Recent findings suggest that fear generalization is closely related to hippocampal dependency during retrieval. The selective serotonin reuptake inhibitor (SSRI) fluoxetine has been used as a first-line treatment for PTSD; however, how it exerts its therapeutic effect remains a matter of debate. Here, using contextual fear conditioning in rats, we show that chronic fluoxetine treatment prevents fear generalization and enhances subsequent extinction. Moreover, fluoxetine treatment after extinction prevents spontaneous recovery. The mechanism through which fluoxetine affects generalization and extinction seems to be through the postponement of systems consolidation, thereby maintaining hippocampal involvement during retrieval. Such an effect relies on a remodeling of dendritic spines in the hippocampus, as well as the number of mature, mushroom-type spines promoted by fluoxetine treatment. In order to further investigate whether fear generalization is a potential predictor of extinction effectiveness, we categorized a large naive population according to their generalization rate. We found that discriminator rats showed a better extinction profile compared to generalizers, suggesting that the generalization rate predicts extinction effectiveness. Hence, we propose that the therapeutic strategy of choice should take into account the extension of memory generalization, in which therapies based on extinction could induce a better outcome in patients who present less fear overgeneralization. These results open new avenues for the development of interventions that prevent fear generalization by maintaining memory dependency of the hippocampus.
Key role of gut microbiota in anhedonia-like phenotype in rodents with neuropathic pain
Authors: Yang Chun , Fang Xi , Zhan Gaofeng , Huang Niannian , Li Shan , Bi Jiangjiang , Jiang Riyue , Yang Ling , Miao Liying , Zhu Bin , Luo Ailin , Hashimoto Kenji 
Published: January 2019

AbstractPatients with chronic neuropathic pain frequently suffer from symptoms of anhedonia, which is a core symptom of depression. Accumulating studies suggest that gut microbiota may play a role in depression via gut–microbiota–brain axis. However, it is unknown whether gut microbiota plays a role in neuropathic pain-associated anhedonia. Here, we used a rat model of spared nerve injury (SNI). Hierarchical cluster analysis of sucrose preference test (SPT) results was used to classify the SNI rats with or without anhedonia-like phenotype. The 16S ribosomal RNA sequencing analysis showed abnormal composition of gut microbiota in the anhedonia susceptible compared to sham-operated rats and resilient rats. Furthermore, antibiotics-treated mice showed pain as well as depression-like and anhedonia-like phenotypes, suggesting a role of gut microbiota in these abnormal behaviors. Transplantation of fecal microbiota from anhedonia susceptible rats into antibiotics-treated pseudo-germ-free mice significantly exaggerated pain and depression-like phenotypes, including anhedonia. In contrast, transplantation of fecal microbiota from resilient rats into antibiotics-treated pseudo-germ-free mice significantly improved pain and depression-like phenotypes, including anhedonia. In conclusion, this study suggests that abnormal composition of gut microbiota may contribute to anhedonia susceptibility post SNI surgery, and that gut microbiota also plays a role in the pain as well as depression-like phenotypes. Interestingly, fecal microbiota transplantation from SNI rats with or without anhedonia can alter pain, depression-like and anhedonia-like phenotypes in the pseudo-germ-free mice. Therefore, it is likely that gut microbiota plays a key role in the pain as well as depression-like phenotypes including anhedonia in rodents with neuropathic pain.
Computerized multi-domain cognitive training reduces brain atrophy in patients with amnestic mild cognitive impairment
Authors: Zhang Haifeng , Wang Zhijiang , Wang Jing , Lyu Xiaozhen , Wang Xiao , Liu Ying , Zeng Xiangzhu , Yuan Huishu , Wang Huali , Yu Xin 
Published: January 2019

AbstractThe present study aimed to explore the effect of computerized multi-domain cognitive training (MDCT) on brain gray matter volume and neuropsychological performance in patients with amnestic mild cognitive impairment (amnestic MCI). Twenty-one patients with amnestic MCI participated in a computerized MDCT program. The program targeted a broad set of cognitive domains via programs focused on reasoning, memory, visuospatial, language, calculation, and attention. Seventeen Participants completed the intervention and all completed a battery of neuropsychological tests to evaluate cognitive function while 12 out of 17 underwent 3 T MRI scanning before and after the intervention to measure gray matter (GM) volume. We examined correlations between the changes in neuropsychological scores and GM volumes across participants after the intervention. After training, we observed significant increases in GM volume in the right angular gyrus (AG) and other parietal subareas near the intraparietal sulcus (p < 0.05, FWE-corrected, 10000 permutations). However, we found no significant changes in neuropsychological test scores (p > 0.05). A correlation analysis revealed positive correlations between the changes in GM volume in the right AG and scores in the immediate recall component of the Hopkins Verbal Learning Test-Revised (HVLT-R) (r = 0.64, p = 0.024) and the Brief Visuospatial Memory Test–Revised (BVMT-R) (r = 0.67, p = 0.016). Our findings indicate that a computerized MDCT program may protect patients with amnestic MCI against brain GM volume loss and has potential in preserving general cognition. Thus, our non-pharmacological intervention may slow the rate of disease progression.
The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model
Authors: Liu Yang , Gao Yamin , Liu Jianxiong , Tan Yaoju , Liu Zhiyong , Chhotaray Chiranjibi , Jiang Huofeng , Lu Zhili , Chiwala Gift , Wang Shuai , Makafe Gaelle , Islam Md Mahmudul , Hameed H. M. Adnan , Cai Xingshan , Wang Changwei , Li Xinjie , Tan Shouyong , Zhang Tianyu 
Published: January 2019

AbstractBuruli ulcer (BU) is an emerging infectious disease that causes disfiguring skin ulcers. The causative agent, Mycobacterium ulcerans, secretes toxin called mycolactone that triggers inflammation and immunopathology. Existing treatments are lengthy and consist of drugs developed for tuberculosis. Here, we report that a pyrazolo[1,5-a]pyridine-3-carboxamide, TB47, is highly bactericidal against M. ulcerans both in vitro and in vivo. In the validated mouse model of BU, TB47 alone reduces M. ulcerans burden in mouse footpads by more than 2.5 log10 CFU compared to the standard BU treatment regimen recommended by the WHO. We show that mutations of ubiquinol-cytochrome C reductase cytochrome subunit B confer resistance to TB47 and the dissimilarity of CydABs from different mycobacteria may account for their differences in susceptibility to TB47. TB47 is highly potent against M. ulcerans and possesses desirable pharmacological attributes and low toxicity that warrant further assessment of this agent for treatment of BU.