bluuebunny/crossref_metadata_2025_split huggingface dataset:
The epidemiology of low back pain in chiropractors and chiropractic students: a systematic review of the literature
Authors: Ead Lauren , Wong Jessica , Hogg-Johnson Sheilah , Mior Silvano , Plener Joshua , Côté Pierre 
Published: November 2024

Abstract
Background
Chiropractors and chiropractic students commonly report low back pain (LBP). However, the burden of LBP in this occupational group has not been synthesized in the literature. This systematic review aims to describe the epidemiology of LBP in chiropractors and chiropractic students.

Methods
We searched MEDLINE, Embase, CINAHL, and PsycINFO from inception to May 1, 2023. Eligible studies were cross-sectional, cohort, or case–control studies investigating the prevalence, incidence, associated factors, or risk factors of LBP in chiropractors or chiropractic students. Reviewers independently screened articles and assessed risk of bias using the appropriate JBI Checklists for the observational study design. We descriptively synthesized studies that were rated as low or moderate risk of bias.

Results
Of 2012 citations screened, we included 2 cross-sectional studies in the evidence synthesis (1 study rated as moderate risk of bias on chiropractors, and 1 rated as low risk of bias on chiropractic students). For chiropractors, the 12-month prevalence of work-related overuse injuries to the low back was 35.6% (95% CI 29.1, 42.0) in women and 22.4% (95% CI 16.3, 29.6) in men. The 12-month prevalence of work-related acute physical injuries to the low back in chiropractors were 3.4% (95% CI 1.6, 6.8) for women and 0.7% (95% CI 0.1, 3.7) for men. Among chiropractic students, the 1-week prevalence of LBP was 69% (95% CI 64.8, 73.0). This was higher among female students (72.5%, 95% CI 67.1, 77.4) and lower among male students (64%, 95% CI 57.0, 70.6).

Conclusion
There is limited high-quality evidence on the epidemiology of LBP in chiropractors and chiropractic students. Our systematic review provides a synthesis of the body of literature, highlighting that chiropractors and chiropractic students commonly report LBP. Future high-quality research is needed to address the incidence, associated factors, and risk factors of LBP.
A systematic review of candidate genes and their relevant pathways for metastasis among adults diagnosed with breast cancer
Authors: Gehling Gina M. , Alfaqih Miad , Pruinelli Lisiane , Starkweather Angela , Dungan Jennifer R. 
Published: November 2024

Abstract
Background
Presently incurable, metastatic breast cancer is estimated to occur in as many as 30% of those diagnosed with early-stage breast cancer. Timely and accurate identification of those at risk for developing metastasis using validated biomarkers has the potential to have profound impact on overall survival rates. Our primary goal was to conduct a systematic review and synthesize the existing body of scientific knowledge on the candidate genes and their respective single nucleotide polymorphisms associated with metastasis-related outcomes among patients diagnosed with breast cancer. This knowledge is critical to inform future hypothesis-driven and validation research aimed at enhancing clinical decision-making for breast cancer patients.

Methods
Using PRISMA guidelines, literature searches were conducted on September 13th, 2023, using PubMed and Embase databases. The systematic review protocol was registered with INPLASY (DOI: https://doi.org/10.37766/inplasy2024.8.0014). Covidence software was used to facilitate the screening and article extraction processes. Peer-reviewed articles were selected if authors reported on single nucleotide polymorphisms directly associated with metastasis among adults diagnosed with breast cancer.

Findings
We identified 451 articles after 44 duplicates were removed resulting in 407 articles to be screened for study inclusion. Three reviewers completed the article screening process which resulted in 86 articles meeting the study inclusion criteria. Sampling varied across studies with the majority utilizing a case-control design (n = 75, 87.2%), with sample sizes ranging from 23 to 1,017 participants having mean age 50.65 ± 4.50 (min-max: 20–75). The synthesis of this internationally generated evidence revealed that the scientific area on the underlying biological contributions to breast cancer metastasis remains predominantly exploratory in nature (n = 74, 86%). Of the 12 studies with reported power analyses, only 9 explicitly stated the power values which ranged from 47.88 to 99%.

Discussion
Understanding the underlying biological mechanisms contributing to metastasis is a critical component for precision oncological therapeutics and treatment approaches. Current evidence investigating the contribution of SNPs to the development of metastasis is characterized by underpowered candidate gene studies. To inform individualized precision health practices and improve breast cancer survival outcomes, future hypothesis-driven research is needed to replicate these associations in larger, more diverse datasets.
Integrated analyses of multi-omic data derived from paired primary lung cancer and brain metastasis reveal the metabolic vulnerability as a novel therapeutic target
Authors: Duan Hao , Ren Jianlan , Wei Shiyou , Yang Zhenyu , Li Chuan , Wang Zhenning , Li Meichen , Wei Zhi , Liu Yu , Wang Xiuqi , Lan Hongbin , Zeng Zhen , Xie Maodi , Xie Yuan , Wu Suwen , Hu Wanming , Guo Chengcheng , Zhang Xiangheng , Liang Lun , Yu Chengwei , Mou Yanhao , Jiang Yu , Li Houde , Sugarman Eric , Deek Rebecca A. , Chen Zexin , Li Tao , Chen Yaohui , Yao Maojin , Chen Likun , Liu Lunxu , Zhang Gao , Mou Yonggao 
Published: November 2024

Abstract
Background
Lung cancer brain metastases (LC-BrMs) are frequently associated with dismal mortality rates in patients with lung cancer; however, standard of care therapies for LC-BrMs are still limited in their efficacy. A deep understanding of molecular mechanisms and tumor microenvironment of LC-BrMs will provide us with new insights into developing novel therapeutics for treating patients with LC-BrMs.

Methods
Here, we performed integrated analyses of genomic, transcriptomic, proteomic, metabolomic, and single-cell RNA sequencing data which were derived from a total number of 154 patients with paired and unpaired primary lung cancer and LC-BrM, spanning four published and two newly generated patient cohorts on both bulk and single cell levels.

Results
We uncovered that LC-BrMs exhibited a significantly greater intra-tumor heterogeneity. We also observed that mutations in a subset of genes were almost always shared by both primary lung cancers and LC-BrM lesions, including TTN, TP53, MUC16, LRP1B, RYR2, and EGFR. In addition, the genome-wide landscape of somatic copy number alterations was similar between primary lung cancers and LC-BrM lesions. Nevertheless, several regions of focal amplification were significantly enriched in LC-BrMs, including 5p15.33 and 20q13.33. Intriguingly, integrated analyses of transcriptomic, proteomic, and metabolomic data revealed mitochondrial-specific metabolism was activated but tumor immune microenvironment was suppressed in LC-BrMs. Subsequently, we validated our results by conducting real-time quantitative reverse transcription PCR experiments, immunohistochemistry, and multiplexed immunofluorescence staining of patients’ paired tumor specimens. Therapeutically, targeting oxidative phosphorylation with gamitrinib in patient-derived organoids of LC-BrMs induced apoptosis and inhibited cell proliferation. The combination of gamitrinib plus anti-PD-1 immunotherapy significantly improved survival of mice bearing LC-BrMs. Patients with a higher expression of mitochondrial metabolism genes but a lower expression of immune genes in their LC-BrM lesions tended to have a worse survival outcome.

Conclusions
In conclusion, our findings not only provide comprehensive and integrated perspectives of molecular underpinnings of LC-BrMs but also contribute to the development of a potential, rationale-based combinatorial therapeutic strategy with the goal of translating it into clinical trials for patients with LC-BrMs.
Influences of sex and gender on the associations between risk and protective factors, brain, and behavior
Authors: Brosch Katharina , Dhamala Elvisha 
Published: November 2024

AbstractRisk and protective factors for psychiatric illnesses are linked to distinct structural and functional changes in the brain. Further, the prevalence of these factors varies across sexes and genders, yet the distinct and joint effects of sex and gender in this context have not been extensively characterized. This suggests that risk and protective factors may map onto the brain and uniquely influence individuals across sexes and genders. Here, we review how specific risk (childhood maltreatment, the COVID-19 pandemic, experiences of racism), and protective factors (social support and psychological resilience) distinctly influence the brain across sexes and genders. We also discuss the role of sex and gender in the compounding effects of risk factors and in the interdependent influences of risk and protective factors. As such, we call on researchers to consider sex and gender when researching risk and protective factors for psychiatric illnesses, and we provide concrete recommendations on how to account for them in future research. Considering protective factors alongside risk factors in research and acknowledging sex and gender differences will enable us to establish sex- and gender-specific brain-behavior relationships. This will subsequently inform the development of targeted prevention and intervention strategies for psychiatric illnesses, which have been lacking. To achieve sex and gender equality in mental health, acknowledging and researching potential differences will lead to a better understanding of men and women, males and females, and the factors that make them more vulnerable or resilient to psychopathology.
Brain-derived neurotrophic factor promotes bone regeneration in a canine model of peri-implantitis
Authors: Kono Shoko , Sasaki Shinya , Matsuda Shinji , Takeda Katsuhiro , Iwata Tomoyuki , Ouhara Kazuhisa , Kajiya Mikihito , Kurihara Hidemi , Mizuno Noriyoshi 
Published: November 2024

Abstract
Purpose
The present study aims to determine whether the brain-derived neurotrophic factor (BDNF)/high-molecular-weight hyaluronic acid (HMW-HA) complex could regenerate bone around implants lost due to peri-implantitis.

Methods
Dogs had their three premolars extracted, and three implants were placed on each side. After osseointegration, 3-0 silk threads were ligated around the healing abutment for 12 weeks. Implants were classified into four groups—no treatment (control group), non-surgical debridement (debridement group), non-surgical debridement with application of HMW-HA (HMW-HA group), and non-surgical debridement with application of BDNF/HMW-HA complex (BDNF/HMW-HA group). Probing pocket depth (PPD), attachment level (AL), and bleeding on probing (BOP) were recorded before and 12 weeks after each treatment. Standardized intraoral radiographs were obtained, and histological analysis was conducted.

Results
The bone level on radiographs significantly improved (median −0.15 mm, IQR −0.31 to 0.10) only in the BDNF/HMW-HA group, while changes in PPD and AL were similar to those in other groups. The BOP positivity rate decreased in the debridement and BDNF/HMW-HA groups. Unlike images of the other groups, histological images of the BDNF/HMW-HA group showed no epithelial migration toward the tip of the implant. Inflammatory cell infiltration was reduced compared with that in the other groups. New bone was observed around the implants only in the BDNF/HMW-HA group.

Conclusions
The BDNF/HMW-HA complex appears to promote bone regeneration when combined with non-surgical debridement for peri-implantitis.
Association between maternal and child health care and neonatal death in Angola: a secondary analysis of Angola Demographic Health Survey 2015–16
Authors: Saito Akiko , Kondo Masahide 
Published: November 2024

Abstract
Background
Neonatal mortality has decreased in Angola; however, it remains high. Quality maternal and child health (MCH) care is key to improving neonatal survival. In Angola, however, the association between neonatal mortality and MCH care has not yet been investigated. Therefore, this study aimed to identify the association between neonatal mortality and MCH services in Angola.

Methods
We used the Angola Demographic Health Survey 2015–16, which is the latest nationally representative dataset of Angola. The associations between early/late neonatal death and MCH care utilization were identified by a multivariable logistic regression analysis, adjusted by the sex of the child, type of residence, wealth index, caesarian section, size of the child at birth and delivery assisted by skilled birth attendant. The individual sample weight, sample strata for sampling errors/design, and cluster number were incorporated in a descriptive and logistic regression analysis to account for the unequal probability sampling in different strata.

Results
The early and late neonatal mortality rates were 22 and 2 per 1000 live births, respectively. We found that having none, one, two or three tetanus injections before the last pregnancy compared to five or more injections, and no postnatal health check for children before discharge were associated with the occurrence of late neonatal death. During the first 2 days after childbirth, no observation of breastfeeding, no counseling on breastfeeding, no counseling on newborn danger signs, no measurement of child body temperature, and no examination of the cord as well as not checking child health before discharge were associated with early neonatal death.

Conclusions
Doses of maternal tetanus vaccination and postnatal child health check before discharge were modifiable factors associated to late neonatal death. Further studies to improve MCH care coverage are needed.
Mi-maml: classifying few-shot advanced malware using multi-improved model-agnostic meta-learning
Authors: Ji Yulong , Zou Kunjin , Zou Bin 
Published: November 2024

AbstractMalware classification has been successful in utilizing machine learning methods. However, it is limited by the reliance on a large number of high-quality labeled datasets and the issue of overfitting. These limitations hinder the accurate classification of advanced malware with only a few samples available. Meta-learning methods offer a solution by allowing models to quickly adapt to new tasks, even with a small number of samples. However, the effectiveness of meta-learning approaches in malware classification varies due to the diverse nature of malware types. Most meta-learning-based methodologies for malware classification either focus solely on data augmentation or utilize existing neural networks and learning rate schedules to adapt to the meta-learning model. These approaches do not consider the integration of both processes or tailor the neural network and learning rate schedules to the specific task. As a result, the classification performance and generalization capabilities are suboptimal. In this paper, we propose a multi-improved model-agnostic meta-learning (MI-MAML) model that aims to address the challenges encountered in few-shot malware classification. Specifically, we propose two data augmentation techniques to improve the classification performance of few-shot malware. These techniques involve utilizing grayscale images and the Lab color space. Additionally, we customize neural network architectures and learning rate schemes based on the representative few-shot classification method, MAML, to further enhance the model’s classification performance and generalization ability for the task of few-shot malware classification. The results obtained from multiple few-shot malware datasets demonstrate that MI-MAML outperforms other models in terms of categorical accuracy, precision, and f1-score. Furthermore, we have conducted ablation experiments to validate the effectiveness of each stage of our work.
Maternal Wealth Implications of Child Incarceration: Examining the Upstream Consequences of Children's Incarceration for Women's Assets, Homeownership, and Home Equity
Authors: Bryan Brielle , Farooqi Hira 
Published: November 2024

Abstract
Qualitative research has documented mothers’ critical role in supporting adult children during and after incarceration. Yet, the implications of incarceration for mothers have been relatively unexplored. Wealth research has also largely overlooked the influence of adult children on parental wealth. Using linked mother–child data from the National Longitudinal Survey of Youth 1979 (NLSY79) and the NLSY79 Child and Young Adult study, we investigate whether a child's incarceration influences mothers’ wealth and whether accounting for child incarceration history helps explain the racial wealth gap. We use an event-study analysis and fixed-effects models to assess the evidence that children's incarceration affects three forms of wealth: financial assets, homeownership, and home equity. We find significant relationships between child incarceration and maternal wealth, but the importance of current versus prior child incarceration depends on the type of wealth considered. We also find that child incarceration is much more detrimental in dollar terms for White women than for Black or Hispanic women, but the financial asset penalty associated with child incarceration is larger in percentage terms for Black women than for White women.
Outcome of Fourth Ventricular Hemorrhage in Ruptured Brain Aneurysms: Impact of Active Blood Clearance and Delayed Cerebral Ischemia Prevention
Authors: Overstijns Manou , Csók István , Watzlawick Ralf , Scheiwe Christian , Reinacher Peter , Beck Jürgen , El Rahal Amir , Roelz Roland 
Published: November 2024

BACKGROUND AND OBJECTIVES:
Blood in the fourth ventricle is associated with poor outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). We investigated (1) the prognostic significance of the amount of blood in the fourth ventricle and (2) the influence of active blood clearance and delayed cerebral ischemia prevention (ABCD).

METHODS:
We reviewed 817 consecutive aSAH patients admitted between January 1, 2009, and December 31, 2022, assessing blood amount in the fourth ventricle using a fourth ventricular hemorrhage scale (FVH): grade 1 (no or minimal blood), grade 2 (partially filled), grade 3 (completely filled/cast), and grade 4 (ballooning). Incidence of poor outcomes was evaluated using multivariate analysis before and after the introduction of ABCD (October 2015). Subsequently, a 1:1 matched-pairs analysis compared outcomes specifically between patients who underwent ABCD and matched controls receiving standard care. Neurological outcomes were evaluated at 6 months (independent modified Rankin scale).

RESULTS:
Before ABCD, poor outcomes occurred in 31/41 FVH grade 3 patients (76%; odds ratio (OR) 4.4) and in 38/41 FVH grade 4 patients (93%; OR 29.1). After ABCD, the incidence of poor outcomes decreased to 23/40 in FVH grade 3 patients (58%; P = .043; OR 1.3) and 31/41 in FVH grade 4 patients (76%; P = .017; OR: 3.6). The matched-pairs analysis also showed improvement in poor outcomes for FVH grade 4 patients who underwent ABCD compared with standard care (64% vs 89%, P = .024), but not for FVH grade 1 to 3 patients. No increase in the incidence of ventriculitis was seen in patients receiving ABCD treatment (P = .836).

CONCLUSION:
Ballooning fourth ventricular hemorrhage (grade 4 FVH) is a powerful predictor of poor outcomes after aSAH. With the introduction of ABCD, the prognosis of these patients improved considerably and 25% reached functional independence 6 months after aSAH.
Evaluation of 2 Surgical Techniques—Transposition Versus Interposition Microvascular Decompression for Hemifacial Spasm: A Systematic Review of 19 437 Patients
Authors: Tugend Margaret , Joncas Colby T. , Lee Veronica , Simmons Grace B. , Sekula Raymond F. 
Published: November 2024

BACKGROUND AND OBJECTIVES:
Hemifacial spasm (HFS) is a rare movement disorder characterized by brisk, irregular, involuntary, and unilateral contraction of the facial musculature. This systematic review aims to synthesize the existing literature and compare the use of 2 microvascular decompression (MVD) techniques—transposition and interposition—used in the treatment of HFS.

METHODS:
A retrospective systematic review of randomized controlled trials, meta-analyses, case-control studies, and case series examining transposition and/or interposition during MVD for HFS was performed using PubMed, Embase, and Scopus databases. Data extracted included study objective and size, surgical method, demographic information, operative technique notes, number and location of offending vessels, complications, follow-up duration, rate of spasm freedom at last follow-up, and additional outcomes. Cohorts of at least 20 patients with HFS treated with MVD reported in studies explicitly mentioning surgical techniques were included.

RESULTS:
PubMed, Embase, and Scopus database searches yielded 1300 records, of which 528 were duplicates. Sixty-two studies reporting 68 cohorts met inclusion criteria, including 5 on transposition, 51 on interposition, and 6 using both techniques. Interposition was used in 18 627 cases, and transposition was used in 810 cases. Spasm freedom at final follow-up was similar between transposition and interposition (90.4% vs 89.6%). Complication rates were similar between techniques, with the largest difference being higher rates of temporary facial nerve weakness/palsy among the transposition series (9.52%) than the interposition series (6.03%).

CONCLUSION:
Both transposition and interposition are safe and effective techniques for MVD in patients with HFS. Available literature to date does not provide conclusive evidence that 1 method is superior to the other in safety or efficacy although there are specific instances that favor the use of interposition. A prospective trial would be required to delineate the true differences between these techniques.
Physical Activity Declines over a 12-Month Period in Parkinson’s Disease: Considerations for Longitudinal Activity Monitoring
Authors: Rosenfeldt Anson B. , Jansen A. Elizabeth , Lopez-Lennon Cielita , Zimmerman Eric , Imrey Peter B. , Dibble Leland E. , Alberts Jay L. 
Published: November 2024

ABSTRACT

Purpose
The purpose of this project was to evaluate trends in daily steps in individuals with Parkinson’s disease (PD) over a 12-month period using continuous activity monitoring. Environmental (temperature) and cultural factors (represented by day of the week) were evaluated as potential external sources of variability. It was hypothesized that participants daily step counts would decline over the course of 12 months. Further, it was hypothesized that participants would take more steps on warmer days and that the day of the week would have minimal impact on step count as many participants were no longer in the workforce.

Methods
Participants were part of the Usual and Customary Care arm (N = 119) of the CYClical Lower Extremity Exercise Trial for Parkinson’s disease - II (CYCLE-II) at the Cleveland Clinic and University of Utah. Participants wore a Garmin Vivofit4® device daily for 12-months. A linear mixed effects model was created to model daily steps over 12-months.

Results
Participants wore their activity monitors 93% of study days. Steps per day declined by 6.1% over 12 months (95% CI 12.6% decline, 0.9% increase, p = 0.09). Steps per day were greater with warmer temperatures (p < 0.001), plateauing and declining around 75-85 degrees Fahrenheit (24-29 degrees Celsius). Participants took fewer steps on Sundays; this difference was more pronounced for Utah participants, who took 25% fewer steps on Sundays compared to other weekdays (p < 0.001).

Conclusions
Most individuals live with PD for decades, and interventions should address the expected decline of 6% in daily step count. Environmental and cultural factors impact daily step count and should be adjusted for in short- and long-term monitoring of physical activity in individuals with PD.