bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ownership structure, adjustment speed toward target leverage and CEO power
Authors: Vo Thi Thuy Anh , Thai Thi Hong An 
Published: October 2024

PurposeThis study aims to investigate the impact of ownership structure on firm adjustment speed toward the target leverage.Design/methodology/approachThe study employs a partial adjustment model on a sample of 694 publicly listed firms from 2007 to 2021 in Vietnam.FindingsThe study finds that state and foreign ownerships inhibit the speed at which firms approach their optimal level of debt. Interestingly, this negative association is less pronounced in firms managed by powerful CEOs (duality CEOs; highly experienced CEOs; CEOs who they own or their families possess a large number of shares). Further, state and foreign ownership are found to be positively associated with firm performance. This beneficial impact weakens, however, when firms use more debts.Originality/valueThe outcome reveals that having a powerful CEO on board can help businesses in this emerging market counteract the detrimental effects that foreign and state ownership leave on the process of adjusting leverage.
Optimal design parameter estimation and analytical investigation of MEMS quadruple touch mode capacitive pressure sensor
Authors: Gajula Rukshana Bi , Jindal Sumit Kumar 
Published: October 2024

Purpose
Touch mode capacitive pressure sensors (TMCPS) offer superior sensitivity and linearity in comparison to normal mode CPS and have therefore seen substantial improvements in modeling and construction. This study aims to develop a sensor that is highly robust, with near-linear output characteristics, increased sensitivity and superior overload protection, making it an ideal choice for deployment in harsh industrial environments.

Design/methodology/approach
The proposed sensor design uses a substrate with a multi-step notch, introducing a new quadruple TMCPS and uses a small deflection model for mathematical analysis. Addition of a multi-step notch to traditional touch mode capacitive sensors results in quadruple touch regions which further enhances its operational range performance.

Findings
The simulation of diaphragm deflection in response to pressure is carried out by using COMSOL Multiphysics, whereas MATLAB is used for analytical simulations pertaining to variations in capacitance and capacitive sensitivity. Comparing with earlier models, there is a noticeable enhancement in capacitance, experiencing a fivefold increase. The achieved value stands at 50.1 pF, reflecting improved sensitivity for applied pressure ranging from 0 to 2 MPa.

Originality/value
In existing literature to improve the performance of the single TMCPS, a double-sided TMCPS has been developed. To enhance sensor performance, a substrate with a multi-step notch is proposed. The notch creates four touch regions with varying gap depths, resulting in increased capacitance and capacitive sensitivity.
Senedd Reform: From Aspiration to Cold‐Headed Reality?
Authors: Evans Adam 
Published: October 2024

AbstractIn May 2024, the Senedd Cymru (Members and Elections) Bill completed its legislative journey through the Senedd Cymru/Welsh Parliament. The bill marks the latest chapter in the Senedd's evolution from an assembly established with no formally separated executive branch and no primary legislative powers into a lawmaking and tax‐raising parliament. It also marks the culmination of a long‐running debate about the size of the Welsh legislature. For at least twenty years there had appeared to be a broad agreement that the Senedd was too small, its capacity too thinly spread and that a larger membership of at least eighty, but closer to ninety or 100, members was required. In those respects, the Senedd Cymru (Members and Elections) Bill can be seen as the culmination of that long‐established consensus. However, as this article will explore, in one key area—the choice of electoral system—the bill marks a key point of departure.
“Lascivious Poison?” Street‐songs as a Source for Popular Expression: The Case of Jansenism, c. 1687–1737*
Authors: Thomason Tiéphaine 
Published: October 2024

AbstractFamed for its austerity, Jansenism nonetheless prompted a slew of salacious street‐songs throughout the seventeenth and eighteenth centuries. If historians have increasingly examined early modern urban singing practices, underlining the social porosity and intergenerational hold of many street‐songs, little research has been devoted to unpicking what songs offer to the study of religious history. The aims of this article are two‐fold. First, it seeks to assess the value (and sketch out some limits) to street‐songs as a source in recovering some of the more popular facets of religious controversies — here, the Jansenist movement. Second, and as a corollary of this, the article uses street‐songs to emphasise the political sophistication to popular interest in Jansenism. It suggests that this antedated and ran alongside the convulsionary movement, which has been typically viewed as the apogee of popular engagement with Jansenism. This article first considers how the hold of specific literary themes and popular tunes over generations impacted discussions on the Jansenist debate, before turning to examine the suitability of songs in capturing devotional and theological content, and finally discussing the complexity of the popular political and ecclesiological ideas on the Jansenist movement that the street‐songs conveyed. The article ultimately seeks to underline the value of street‐songs as a source on urban popular religious expression.
Transanal total mesorectal excision: Understanding indications, managing complications, and effective prevention methods
Authors: Stefanou Christos K. , Stefanou Stefanos K. , Tepelenis Kostas , Chatzoglou Theocharis , Smyris Thomas Iraklis , Aikaterini Marini , Barbouti Alexandra , Varvarousis Dimitrios N. , Kanavaros Panagiotis , Kitsoulis Panagiotis 
Published: October 2024

AbstractTransanal total mesorectal excision (TaTME) has emerged as a surgical method for treating rectal malignancies in the middle and lower third of the rectum over the past 15 years. This approach was adopted because of the challenges encountered in secure total mesorectal excision (TME). Patient selection criteria and the rationale for TaTME have evolved, leading to improved oncological outcomes and patient quality of life. The procedure includes inserting a unique platform through the anus, forming a purse‐string closure, and endoscopically sealing the lower rectum. The mesorectum is then removed laparoscopically following a ‘down‐to‐up’ approach, finalised with a transabdominal laparoscopic phase and anastomosis. Pelvic anatomy complexity poses challenges, including potential injuries to the urinary tract, surgical site leakage, sinus damage, sagittal vein harm, nerve injury, carbon dioxide embolism, bowel function disturbance, sphincter mechanism issues, and rectal abscess formation. Proficient anatomy knowledge, precise surgical techniques, and advanced technologies contribute to their prevention. In conclusion, TaTME offers a promising approach to rectal surgery with satisfactory oncological outcomes. However, vigilance is required to eliminate potential complications.
Gut microbiota, serum metabolites, and lipids related to blood glucose control and type 1 diabetes
Authors: Gu Zhaohe , Pan Lanxin , Tan Huiling , Wang Xulin , Wang Jing , Zheng Xueying , Weng Jianping , Luo Sihui , Yue Tong , Ding Yu 
Published: October 2024

AbstractBackgroundThe composition and function of gut microbiota, lipids, and metabolites in patients with type 1 diabetes (T1D) or its association with glycemic control remains unknown. We aimed to use multi‐omics sequencing technology and machine learning (ML) approaches to investigate potential function and relationships among the gut microbiota, lipids, and metabolites in T1D patients at varied glycemic levels.MethodsWe conducted a multi‐omics analysis of the gut microbiome from fecal samples, metabolites, and lipids obtained from serum samples, collected from a cohort of 72 T1D patients. The patients were divided into two groups based on their hemoglobin A1c (HbA1c) levels. 16S rRNA sequencing, and metabolomics methods were applied to analyze changes in composition and function of gut microbiota, metabolites, and lipids.ResultsThe linear discriminant analysis, Shapley additive explanations (SHAP) algorithm, and ML algorithms revealed the enrichment of Bacteroides_nordii, Bacteroides_cellulosilyticus in the glycemic control (GC) group, while Bacteroides_coprocola and Sutterella_wadsworthensis were enriched in the poor glycemic control (PGC) group. Several metabolic enrichment sets like fatty acid biosynthesis and glycerol phosphate shuttle metabolism were different between two groups. Bacteroides_nordii exhibited a negative association with D‐fructose, a component involved in the starch and sucrose metabolism pathway, as well as with monoglycerides (16:0) involved in the glycerolipid metabolism pathway.ConclusionsWe identified distinct characteristics of gut microbiota, metabolites, and lipids in T1D patients exhibiting different levels of glycemic control. Through comprehensive analysis, microbiota (Bacteroides_nordii, Bacteroides_coprocola), metabolites (D‐fructose), and lipids (Monoglycerides) may serve as potential mediators that communicated the interaction between the gut, circulatory systems, and glucose fluctuations in T1D patients.image
CircSEC24A induces KLF8 expression to promote the malignant progression of non‐small cell lung cancer by regulating miR‐1253
Authors: Xiong Wei , Yang Jinhua 
Published: October 2024

AbstractObjectivesThis study aimed to analyze the role of circSEC24A in non‐small cell lung cancer (NSCLC) and its underlying mechanism.MethodsRNA levels of circSEC24A, microRNA‐1253 (miR‐1253), and KLF transcription factor 8 (KLF8) were detected by quantitative real‐time polymerase chain reaction. Protein expression was analyzed by western blot or immunohistochemistry assay. Cell proliferation and apoptosis were investigated by colony formation assay, 5‐ethynyl‐2′‐deoxyuridine assay, and flow cytometry analysis. Glycolysis was evaluated by commercial kits. Dual‐luciferase reporter assay and RNA immunoprecipitation assay were conducted to identify the associations among circSEC24A, miR‐1253, and KLF8. Xenograft mouse model assay was used to evaluate the effect of circSEC24A on tumor tumorigenesis.ResultsCircSEC24A and KLF8 were upregulated, while miR‐1253 was downregulated in NSCLC. CircSEC24A knockdown inhibited proliferation and glycolysis but induced the apoptosis of NSCLC cells. CircSEC24A acted as a miR‐1253 sponge and regulated NSCLC cell malignancy by targeting miR‐1253. KLF8 was identified as a target of miR‐1253, and its overexpression attenuated miR‐1253‐induced effects in NSCLC cells. Besides, circSEC24A upregulated KLF8 by sponging miR‐1253. Further, circSEC24A knockdown suppressed NSCLC cell tumorigenesis in vivo.ConclusionsCircSEC24A silencing inhibited NSCLC cell malignancy through the miR‐1253/KLF8 pathway, providing a potential therapeutic target for NSCLC.
The role of accounting conservatism in corporate innovation
Authors: Bai Min , Kent Pamela , Kim Sujin , Li Shan 
Published: October 2024

AbstractWe provide evidence to determine whether conservative financial reporting is associated with firm‐level investments in innovation in China. We find that firms adopting a more conservative reporting policy invest substantially more in innovative projects. We also find that conservative reporting practices improve the association between executives' pay‐for‐performance and a firm's innovation efforts. The association between conservatism and firm‐level innovation is concentrated in firms that are in the non‐high‐tech industries, that have higher financial leverage and more product market competition. Our paper adds to public policy by providing evidence of the beneficial influence of accounting conservatism on higher innovation investment.
Gender diversity and corporate social responsibility performance: A critical assessment
Authors: Qian Wei , Rao Kathy , Deng Xin 
Published: October 2024

AbstractPrevious research predominantly used quantitative data to examine the relationship between female representation and corporate social responsibility (CSR) performance. Little is known as to how female leaders drive CSR changes in practice. This study explores the complexities and paradoxes of gender roles in CSR engagement based on 20 in‐depth interviews with female leaders. We find that although gender traits from social roles are relevant, women leaders face considerable challenges in navigating the power dynamics prevalent in boardrooms when driving CSR initiatives. The pronounced power imbalance compels them to reframe CSR within the dominant board discourse and mobilise rhetorical and narrative strategies to acquire authority and alter power dynamics within board CSR decisions.
Large language models to facilitate pregnancy prediction after in vitro fertilization
Authors: Cao Ping , Acharya Ganesh , Salumets Andres , Zamani Esteki Masoud 
Published: October 2024

AbstractWe evaluated the efficacy of large language models (LLMs), specifically, generative pre‐trained transformer‐4 (GPT‐4), in predicting pregnancy following in vitro fertilization (IVF) treatment and compared its accuracy with results from an original published study. Our findings revealed that GPT‐4 can autonomously develop and refine advanced machine learning models for pregnancy prediction with minimal human intervention. The prediction accuracy was 0.79, and the area under the receiver operating characteristic curve (AUROC) was 0.89, exceeding or being at least equivalent to the metrics reported in the original study, that is, 0.78 for accuracy and 0.87 for AUROC. The results suggest that LLMs can facilitate data processing, optimize machine learning models in predicting IVF success rates, and provide data interpretation methods. This capacity can help bridge the knowledge gap between data scientists and medical personnel to solve the most pressing clinical challenges. However, more experiments on diverse and larger datasets are needed to validate and promote broader applications of LLMs in assisted reproduction.
Prevalence of Low FIB‐4 in MASLD‐Related Hepatocellular Carcinoma: A Multicentre Study
Authors: Tan Darren Jun Hao , Tamaki Nobuharu , Kim Beom Kyung , Wijarnpreecha Karn , Aboona Majd Bassam , Faulkner Claire , Kench Charlotte , Salimi Shirin , Sabih Abdul‐Hamid , Lim Wen Hui , Danpanichkul Pojsakorn , Tay Benjamin , Teh Yiqing , Mok John , Nah Benjamin , Ng Cheng Han , Muthiah Mark , Kulkarni Anand V. , Lee Sung Won , Liu Ken , Loomba Rohit , Huang Daniel Q. ,   the Global Liver Cancer Consortium
Published: October 2024

ABSTRACTBackgroundMajor society guidelines recommend the fibrosis‐4 index (FIB‐4) as the initial step to risk stratifying people with metabolic dysfunction‐associated steatotic liver disease (MASLD). We aimed to evaluate the proportion of people with MASLD‐related hepatocellular carcinoma (HCC) and a low FIB‐4.MethodsThis cohort study included 613 consecutive adults (33% female) diagnosed with MASLD‐related HCC from January 2008 to August 2023 at seven international centres in Australia, India, Japan, South Korea, Singapore and the United States. The primary objective was to determine the proportion of participants with a low FIB‐4, defined as FIB‐4 < 1.3, or < 2 if age > 65 years, in people without cirrhosis.ResultsThe mean (±SD) age and body mass index were 71 (±11) years and 27 (±7) kg/m2, respectively. Overall, 235 participants (38%) did not have known cirrhosis. The median FIB‐4 was 3.90 (IQR 2.42–6.42). A total of 78 participants (13%) had a low FIB‐4. Among participants without known cirrhosis (n = 235), 62 participants (26%) had a low FIB‐4. Participants with a low FIB‐4 had larger median total tumour diameter (p < 0.001) and lower median serum alpha‐fetoprotein (p = 0.005), compared to participants without a low FIB‐4. Cirrhosis was associated with lower odds of low FIB‐4, but not other factors such as male sex, type 2 diabetes, or obesity.ConclusionMore than a quarter of those with MASLD‐related HCC without cirrhosis have a low FIB‐4. The proposed clinical care pathways may not identify these people for further evaluation.
Challenges and opportunities for open access book publishing: A perspective from a society publisher in the geosciences
Authors: Lunn Jenny , Lajtha Kate 
Published: October 2024

AbstractThe American Geophysical Union (AGU), a scholarly society serving the Earth and space sciences, has a conventional books portfolio with their publisher, Wiley, and a new partnership with the Geological Society of London for an open access (OA) book series. The latter serves authors who need (because of funding mandates) or want to publish OA and comes with added benefits, including a production workflow to facilitate faster times to online publication. Flexibility in how the costs of individual volumes can be covered aims to encourage uptake, but challenges lie ahead in ensuring that all authors can equitably choose OA for their book project. This commentary contributes to the collection in Area about the evolving OA books landscape, addressing many of the challenges described by Gandy, and describing the start of AGU's journey towards OA books. It brings a perspective from the sciences, where books are mostly large, edited volumes with many international contributors, many of them physical geographers. Their experiences of funding, motivation and recognition for contributing to books may be quite different to human geographers more familiar with the sole‐authored monograph format.
Same goal, different measures: Obscure transformation in Japan's food security policy (1970–2020)
Authors: Sasada Hironori , Ito Takayuki 
Published: October 2024

AbstractFor decades, the Japanese Ministry of Agriculture has implemented various measures to ensure a stable food supply, considering food security a top priority due to the increasing uncertainty of the global economy. However, the ministry's food security policy has evolved substantially with a disproportionate focus on the domestic production of specific food products. This policy change occurred without being widely recognized by the public, media, or intellectuals. Why has the Agricultural Ministry's policy changed even though its goal has remained the same? By applying both qualitative and quantitative research methods, we investigated the context behind this obscure policy transition. Our findings reveal that, contrary to conventional understanding, this policy shift occurred not so much due to political pressure from the agricultural sector, but mainly because of a change in the definition of a key policy concept (i.e., the food self‐sufficiency rate) in the late 1980s.
Haematopoietic cell transplantation for 106 infants and preschoolers with acquired and inherited bone marrow failures
Authors: Loth Gisele , Dumke Cilmara C. K. , Muratori Rafaella R. , Pelegrina Polliany D. , Peixoto Carolina M. A. , Bach Juliana L. M. , Nichele Samantha , Trennepohl Joanna P. , Koliski Adriana , Mousquer Rebeca T. G. , Rodrigues Adriana M. , Marchesini Rafael , Feitosa Margareth K. , Pilonetto Daniela V. , Gouvea Lara , Benini Fernanda M. L. , Pirolli Emanuele S. , Tutumi Rebeca A. F. , Lima Alberto C. M. , Pasquini Ricardo , Bonfim Carmem 
Published: October 2024

SummaryAplastic anaemia in infants and young children presents unique challenges due to high prevalence of inherited bone marrow failure syndromes (IBMFS) in this age group. The objective of this study is assessing clinical characteristics and outcomes of haematopoietic cell transplantation in children ≤5 years with bone marrow failure syndromes. We analysied 106 patients (66% males), median age 4.6 years, including 40 with Fanconi anaemia (FA), 32 with Acquired Severe Aplastic anaemia (aSAA), 15 with Diamond–Blackfan Anaemia, 11 with Amegakaryocytic Purpura and 8 with other IBMFS. Molecular testing was limited (39%), with 25.4% confirmed genetically. Retrospective longitudinal study across three paediatric transplantation centres (1982–2020). Overall survival (OS) was 76.4% over a median 10‐year follow‐up. OS rates were similar between aSAA and IBMFS (FA 77.5%, other IBMFS 76.5%). Transplant‐related mortality (TRM) was lower in aSAA (9.4%) compared with IBMFS (16.2%). Recent years showed improved outcomes, with TRM declining post‐2010. Choice of stem cell source impacted OS, favouring bone marrow over umbilical cord, but showing encouraging results with haploidentical. Late complications were common, including endocrine‐metabolic issues and delayed neuropsychomotor development. Diagnosing and managing bone marrow failures in young children pose significant challenges. Despite advancements in transplant practices, ongoing vigilance and comprehensive care are necessary to improve long‐term survival rates.
Sequencing of therapy for patients with diffuse large B‐cell lymphoma in the era of novel drugs
Authors: Karsten Imke E. , Shumilov Evgenii , Schmitz Norbert , Lenz Georg 
Published: October 2024

SummaryDiffuse large B‐cell lymphoma (DLBCL) is the most common aggressive lymphoma, accounting for ~40% of all cases in adults. Whilst approximately two‐thirds of DLBCL patients can be cured by first‐line therapy, one‐third of patients are primary refractory or relapse after an initial response (r/r DLBCL). Recent advances in the treatment of DLBCL have been achieved by a plethora of novel drugs, such as monoclonal antibodies, antibody–drug conjugates (ADC), bi‐specific T‐cell engagers (BITEs), and CD‐19 directed chimeric antigen receptor (CAR)‐T‐cell therapies. The increasing number of therapeutic options significantly improved the outcome of patients; however, the therapeutic algorithm has become increasingly complex. In this review, we provide an overview of novel therapies for DLBCL patients and potential treatment sequencing from first to second, third, and later lines.
The role of perspective‐taking in attenuating self‐group distancing in women managers
Authors: Bosak Janine , Kulich Clara , Paustian‐Underdahl Samantha C. , Dingli Rachelle Borg 
Published: October 2024

AbstractContrary to expectations about solidarity and sisterhood between women, women managers sometimes distance themselves from junior women in the workplace when facing identity threat, that is, the feeling that one's social identity—such as race or gender—is devalued or undermined. For example, women managers might distance themselves from lower status junior women by seeing themselves as more masculine and career committed than their junior women colleagues. To advance our understanding of how to combat self‐group distancing, the present research proposed and tested whether taking the perspective of junior women would attenuate these ingroup‐distancing tendencies in women managers. Findings from a field study and an experimental study indicated that women managers reported greater self‐distancing from junior women (on masculine trait perceptions) compared to women employees. As predicted, this effect was attenuated for women managers with high levels of perspective‐taking (Study 1) and for women who were experimentally led to take the perspective of junior women (Study 2). For ratings of career commitment and support for affirmative actions, we did not replicate the self‐ingroup distancing effect reported in the literature. Theoretical and practical implications of these findings are discussed.