bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peripheral milling-induced residual stress and its effect on tensile–tensile fatigue life of aeronautic titanium alloy Ti–6Al–4V
Authors: Yang Dong , Xiao Xiao , Liu Yulei , Sun Jing 
Published: March 2019

ABSTRACTThe special application environment puts forward the higher requirement of reliability of parts made from titanium alloy Ti–6Al–4V, which is closely related to the machining-induced residual stress. For the fact of the non-linear distribution of residual stress beneath the machined surface, distribution of peripheral milling-induced residual stress and its effect on fatigue performance of titanium alloy Ti–6Al–4V are still confusing. In the present study, residual stress profile induced by peripheral milling of Ti–6Al–4V is first studied. And then, energy criteria are proposed to characterise the whole state of the residual stress field. Finally, the effects of residual stress profile and surface energy on tensile–tensile fatigue performance of titanium alloy Ti–6Al–4V are discussed. The conclusions were drawn that the variation trend of surface residual stress (σr,Sur), maximum compressive residual stress (σC,ax), location (hr0) and response depth (hry) of residual stress profile with cutting parameters showed a similar pattern for both measure directions those parallel (σ1) and perpendicular (σ3) to the cutting direction. Cutting speed and feed rate have a main effect on surface residual stress, and the depth of cut has little effect on all the four key factors of residual stress profile. With the increase of cutting speed and feed rate, machining-induced surface energy tends to become larger. But increasing the depth of cut caused the strain energy stored in unit time to decrease. Furthermore, the effect of depth of cut on surface energy was weakened when the value of cutting depth becomes larger. Both the surface compressive residual stress and the maximum compressive residual stress are beneficial for prolonging the fatigue life, while large value of machining-induced surface energy leads to a decrease of fatigue life. Analysis of variance result shows that maximum residual compressive stress has a greater impact on fatigue life than other residual stress factors.
UNSOUND INFERENCES MAKE PROOFS SHORTER
Authors: AGUILERA JUAN P. , BAAZ MATTHIAS 
Published: March 2019

AbstractWe give examples of calculi that extend Gentzen’s sequent calculusLKby unsound quantifier inferences in such a way that (i) derivations lead only to true sequents, and (ii) proofs therein are nonelementarily shorter thanLK-proofs.
WOODIN FOR STRONG COMPACTNESS CARDINALS
Authors: DIMOPOULOS STAMATIS 
Published: March 2019

AbstractWoodin and Vopěnka cardinals are established notions in the large cardinal hierarchy and it is known that Vopěnka cardinals are the Woodin analogue for supercompactness. Here we give the definition of Woodin for strong compactness cardinals, the Woodinised version of strong compactness, and we prove an analogue of Magidor’s identity crisis theorem for the first strongly compact cardinal.
Overcoming the Limits of Legal Opportunity Structures: LGBT Rights’ Divergent Paths in Costa Rica and Colombia
Authors: Wilson Bruce M. , Gianella-Malca Camila 
Published: March 2019

ABSTRACTCosta Rica and Colombia, two of the earliest Latin American countries to protect many LGBT rights, attempted to amplify those rights and litigate same-sex marriage (SSM) in mid-2000s; however, these attempts sparked a major anti-LGBT backlash by religious and conservative organizations. Yet a decade later, Colombia legalized SSM while Costa Rica still lacks the right to SSM. Using a most-similar systems comparative case study, this study engages the judicial politics literature to explain this divergent outcome. It details how courts, while staying receptive to many individual LGBT rights claims, deferred SSM legalization to popularly elected branches. In spite of the lack of legislative success in both countries, in Colombia a new litigation strategy harnessed that deference to craft a litigated route to legalized SSM. In Costa Rica, the courts’ lack of conditions or deadlines has left SSM foundering in the congress.
Making National Participatory Institutions Work: Bureaucrats, Activists, and AIDS Policy in Brazil
Authors: Rich Jessica A. J. 
Published: March 2019

ABSTRACTWhat are the conditions under which participatory institutions increase the voice of marginalized groups in policymaking? Existing studies of local participatory institutions highlight the role of leftist politicians and a strong civil society in determining outcomes, yet they fail to explain significant variation among participatory institutions at the national level. Examining the case of Brazil’s AIDS policy sector, this article argues that to fully understand the dynamics of national participatory governance, we must consider the role of bureaucrats. As studies of state-society synergy have shown, bureaucrats may seek outside political support from civil society when other actors inside the state prevent them from advancing their policy preferences. National bureaucrats may create new participatory institutions, and even help civil society delegates coordinate their engagement in such institutions, as strategies to strengthen their policy alliances with civil society.
On non-autonomously forced Burgers equation with periodic and Dirichlet boundary conditions
Authors: Kalita Piotr , Zgliczyński Piotr 
Published: March 2019

AbstractWe study the non-autonomously forced Burgers equation
$$u_t(x,t) + u(x,t)u_x(x,t)-u_{xx}(x,t) = f(x,t)$$
on the space interval (0, 1) with two sets of the boundary conditions: the Dirichlet and periodic ones. For both situations we prove that there exists the unique H1 bounded trajectory of this equation defined for all t ∈ ℝ. Moreover we demonstrate that this trajectory attracts all trajectories both in pullback and forward sense. We also prove that for the Dirichlet case this attraction is exponential.
Abnormal dynamic functional network connectivity in unmedicated bipolar and major depressive disorders based on the triple-network model
Authors: Wang Junjing , Wang Ying , Huang Huiyuan , Jia Yanbin , Zheng Senning , Zhong Shuming , Chen Guanmao , Huang Li , Huang Ruiwang 
Published: March 2019

AbstractBackgroundPrevious studies have analyzed brain functional connectivity to reveal the neural physiopathology of bipolar disorder (BD) and major depressive disorder (MDD) based on the triple-network model [involving the salience network, default mode network (DMN), and central executive network (CEN)]. However, most studies assumed that the brain intrinsic fluctuations throughout the entire scan are static. Thus, we aimed to reveal the dynamic functional network connectivity (dFNC) in the triple networks of BD and MDD.MethodsWe collected resting state fMRI data from 51 unmedicated depressed BD II patients, 51 unmedicated depressed MDD patients, and 52 healthy controls. We analyzed the dFNC by using an independent component analysis, sliding window correlation and k-means clustering, and used the parameters of dFNC state properties and dFNC variability for group comparisons.ResultsThe dFNC within the triple networks could be clustered into four configuration states, three of them showing dense connections (States 1, 2, and 4) and the other one showing sparse connections (State 3). Both BD and MDD patients spent more time in State 3 and showed decreased dFNC variability between posterior DMN and right CEN (rCEN) compared with controls. The MDD patients showed specific decreased dFNC variability between anterior DMN and rCEN compared with controls.ConclusionsThis study revealed more common but less specific dFNC alterations within the triple networks in unmedicated depressed BD II and MDD patients, which indicated their decreased information processing and communication ability and may help us to understand their abnormal affective and cognitive functions clinically.
Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders
Authors: Steen Nils Eiel , Dieset Ingrid , Hope Sigrun , Vedal Trude S.J. , Smeland Olav B. , Matson Wayne , Kaddurah-Daouk Rima , Agartz Ingrid , Melle Ingrid , Djurovic Srdjan , Jönsson Erik G. , Bogdanov Mikhail , Andreassen Ole A. 
Published: March 2019

AbstractBackgroundWe aimed at exploring potential pathophysiological processes across psychotic disorders, applying metabolomics in a large and well-characterized sample of patients and healthy controls.MethodsPatients with schizophrenia and bipolar disorders (N = 212) and healthy controls (N = 68) had blood sampling with subsequent metabolomics analyses using electrochemical coulometric array detection. Concentrations of 52 metabolites including tyrosine, tryptophan and purine pathways were compared between patients and controls while controlling for demographic and clinical characteristics. Significant findings were further tested in medication-free subsamples.ResultsSignificantly decreased plasma concentrations in patients compared to healthy controls were found for 3-hydroxykynurenine (3OHKY, p = 0.0008), xanthurenic acid (XANU, p = 1.5×10−5), vanillylmandelic acid (VMA, p = 4.5×10−5) and metanephrine (MN, p = 0.0001). Plasma concentration of xanthine (XAN) was increased in the patient group (p = 3.5×10−5). Differences of 3OHKY, XANU, VMA and XAN were replicated across schizophrenia spectrum disorders and bipolar disorders subsamples of medication-free individuals.ConclusionsAlthough prone to residual confounding, the present results suggest the kynurenine pathway of tryptophan metabolism, noradrenergic and purinergic system dysfunction as trait factors in schizophrenia spectrum and bipolar disorders. Of special interest is XANU, a metabolite previously not found to be associated with bipolar disorders.
Relationship quality and functional limitations among older adults with cardiovascular disease in the United States of America
Authors: Yu Yan-Liang , Zhang Zhenmei 
Published: March 2019

AbstractSubstantial research shows that cardiovascular disease is a major cause of disability in the United States of America (USA) and worldwide. Despite the well-documented significance of intimate partnerships for cardiovascular health and disease management, how relationship quality contributes to the functional health of older adults diagnosed with cardiovascular disease is much less understood than mental health and mortality risk. Informed by the disablement process model and the lifecourse perspective, this study examines the association between relationship quality and functional limitations among partnered older adults aged 50 years and older diagnosed with cardiovascular disease in the USA. Data are from the Health and Retirement Study, 2006–2012 (N = 1,355). Multi-level linear regression analyses show that baseline negative relationship quality is significantly associated with increased functional limitations over the two- and four-year follow-ups. Additionally, the link between negative relationship quality and functional limitations is stronger among older adults with lower household income over a two-year span, compared to their higher-income counterparts, suggesting that these older adults are doubly disadvantaged by higher relationship strains and limited economic resources. Our findings demonstrate the significance of relationship quality for the functional health of older adults with cardiovascular disease and shed light on the importance of marriage/partnerships as an important social context for a critical stage in the disablement process (i.e. functional limitations).
Recalculation of the Solvency II transitional measures on technical provisions
Authors: Cooke J. , Scott A. , Smith D. , Rogan A. , Cooper R. , Morgan S. , Plotnek A. , Kenyon N. , Bhalla S. 
Published: March 2019

Abstract
Solvency II came into force on 1 January 2016 and included a transitional measure on technical provisions (“TMTP”) designed to help smooth in the capital impact of Solvency II over a 16-year period. The working party’s view is that the main intention of the TMTP is to mitigate the impact of the introduction of the risk margin, which significantly increases the technical provisions of firms, relative to their Solvency I Pillar 2 liabilities.
The majority of firms who hold a TMTP have now had at least one recalculation approved by the Prudential Regulation Authority (PRA); or are in the process of applying for a recalculation. Despite this large number of approved recalculations, there remains significant uncertainty in the industry around the approach and triggers for recalculation.
This paper considers aspects of TMTP recalculation for regulated UK life firms, for example practicalities of the calculation, asset and liability considerations, and communications/announcements.
In this paper, we outline the need for pragmatism when considering the approach to recalculation of a measure originally intended to serve as the bridge between two regimes. We call for an allowance for doing what is sensible in a principles-based regime balancing what might be more theoretically correct with what is practical and possible to support effective management of the business.
Preplant and Residual Herbicide Application Timings for Weed Control in No-Till Soybean
Authors: Vollmer Kurt M. , VanGessel Mark J. , Johnson Quintin R. , Scott Barbara A. 
Published: March 2019

AbstractTimely herbicide applications for no-till soybean can be challenging given the diverse communities of both winter and summer annual weeds that are often present. Research was conducted to compare various approaches for nonselective and preplant weed control for no-till soybean. Nonselective herbicide application timings of fall (with and without a residual herbicide) followed by early-spring (4 wk before planting), late-spring (1 to 2 wk before planting), or sequential-spring applications (4 wk before planting and at planting) were compared. Spring applications also included a residual herbicide. For consistent control of winter annual weeds, two herbicide applications were needed, either a fall application followed by a spring application or sequential-spring applications. When a fall herbicide application did not include a residual herbicide, greater winter annual weed control resulted from early- or sequential-spring treatments. However, application timings that effectively controlled winter annual weeds did not effectively control summer annual weeds that have a prolonged emergence period. Palmer amaranth and large crabgrass control at 4 wk after planting was better when the spring residual treatment (chlorimuron plus metribuzin) was applied 1 to 2 wk before planting or at planting, compared with 4 wk before planting. Results indicate that in order to optimize control, herbicide application programs in soybean should coincide with seasonal growth cycles of winter and summer annual weeds.
Robust Regional Warming Amplifications Directly Following the Anthropogenic Emission
Authors: Xie Yongkun , Huang Jianping , Ming Yi 
Published: March 2019

AbstractAmplified regional warming suggests that some regions suffer more from global warming. However, present knowledge is still not enough to understand this paramount aspect of global warming. By using climate model simulations, we first highlight that regional warming amplifications directly following anthropogenic emission would torment many undeveloped countries. Then, we find that cloud has the largest contribution to polar amplification, rather than the frequently blamed sea ice decline. The summertime sea ice decline plays the second role in generating strong wintertime polar amplification via lagged energy release. Our findings also propose that heat uptake by the deeper ocean greatly favors the terrestrial amplification. Additionally, the cloud also shows its importance in helping dryland amplification. Our findings suggest that these robust regional warming amplifications are very likely inevitable under anthropogenic emission, therefore strictest global mitigation is required to prevent unacceptable warming over the high risk regions.
Global Opportunities to Increase Agricultural Independence Through Phosphorus Recycling
Authors: Powers S. M. , Chowdhury R. B. , MacDonald G. K. , Metson G. S. , Beusen A. H. W. , Bouwman A. F. , Hampton S. E. , Mayer B. K. , McCrackin M. L. , Vaccari D. A. 
Published: March 2019

AbstractFood production hinges largely upon access to phosphorus (P) fertilizer. Most fertilizer P used in the global agricultural system comes from mining of nonrenewable phosphate rock deposits located within few countries. However, P contained in livestock manure or urban wastes represents a recyclable source of P. To inform development of P recycling technologies and policies, we examined subnational, national, and global spatial patterns for two intersections of land use affording high P recycling potential: (a) manure‐rich cultivated areas and (b) populous cultivated areas. In turn, we examined overlap between P recycling potential and nation‐level P fertilizer import dependency. Populous cultivated areas were less abundant globally than manure‐rich cultivated areas, reflecting greater segregation between crops and people compared to crops and livestock, especially in the Americas. Based on a global hexagonal grid (290‐km2 grid cell area), disproportionately large shares of subnational “hot spots” for P recycling potential occurred in India, China, Southeast Asia, Europe, and parts of Africa. Outside of China, most of the remaining manure‐rich or populous cultivated areas occurred within nations that had relatively high imports of P fertilizer (net P import:consumption ratios ≥0.4) or substantial increases in fertilizer demand between the 2000s (2002–2006) and 2010s (2010–2014). Manure‐rich cultivated grid cells (those above the 75th percentiles for both manure and cropland extent) represented 12% of the global grid after excluding cropless cells. Annually, the global sum of animal manure P was at least 5 times that contained in human excreta, and among cultivated cells the ratio was frequently higher (median = 8.9). The abundance of potential P recycling hot spots within nations that have depended on fertilizer imports or experienced rising fertilizer demand could prove useful for developing local P sources and maintaining agricultural independence.
SST Dynamics at Different Scales: Evaluating the Oceanographic Model Resolution Skill to Represent SST Processes in the Southern Ocean
Authors: Skákala Jozef , Smyth Tim J. , Torres Ricardo , Buckingham Christian E. , Brearley Alexander , Hyder Pat , Coward Andrew C. 
Published: March 2019

AbstractIn this study we demonstrate the many strengths of scale analysis: we use it to evaluate the Nucleus for European Modelling of the Ocean model skill in representing sea surface temperature (SST) in the Southern Ocean by comparing three model resolutions: 1/12°, 1/4°, and 1°. We show that while 4–5 times resolution scale is sufficient for each model resolution to reproduce the magnitude of satellite Earth Observation (EO) SST spatial variability to within ±10%, the representation of ∼100‐km SST variability patterns is substantially (e.g., ∼50% at 750 km) improved by increasing model resolution from 1° to 1/12°. We also analyzed the dominant scales of the SST model input drivers (short‐wave radiation, air‐sea heat fluxes, wind stress components, wind stress curl, and bathymetry) variability with the purpose of determining the optimal SST model input driver resolution. The SST magnitude of variability is shown to scale with two power law regimes separated by a scaling break at ∼200‐km scale. The analysis of the spatial and temporal scales of dominant SST driver impact helps to interpret this scaling break as a separation between two different dynamical regimes: the (relatively) fast SST dynamics below ∼200 km governed by eddies, fronts, Ekman upwelling, and air‐sea heat exchange, while above ∼200 km the SST variability is dominated by long‐term (seasonal and supraseasonal) modes and the SST geography.
Geochemical Variability Along the Northern East Pacific Rise: Coincident Source Composition and Ridge Segmentation
Authors: Mallick Soumen , Salters Vincent J. M. , Langmuir Charles H. 
Published: March 2019

AbstractNew trace element abundances and isotope compositions for more than 100 mid‐ocean ridge basalts from 5.5°N to 19°N on the East Pacific Rise show step function variations in isotopic composition along the ridge axis that coincide with ridge discontinuities. Transform faults, overlapping spreading centers, and devals (deviation from axial linearity) mark the separation of individual clusters of distinct isotopic composition and trace element ratios that indicate source variations. This correlated chemical clustering and morphological segmentation indicates that source composition and segmentation can be closely related even on a fine scale. Substantial chemical variations within a segment are related to source composition. This suggests that even within segments the magma transport is mainly vertical, and there is limited along‐ridge transport, and there is little evidence for magma chambers that are well mixed along strike. Trace element concentrations show good correlations with isotopic compositions on a segment scale but less so on a regional scale. The trace element and isotopic variability along the northern East Pacific Rise can be explained by three mantle components: a depleted peridotite endmember, an enriched peridotite endmember, and a recycled gabbro‐like component. The gabbroic component has an isotopic signature indicating an ancient origin. The high‐resolution sampling indicates that within a segment the chemical variability is largely binary but that the endmembers of the binary mixing change from segment to segment. The endmembers of the binary variation within a segment are a combination of three of the endmembers.
A novel compound heterozygous mutation in TTC8 identified in a Japanese patient
Authors: Sato Shigeru , Morimoto Takeshi , Hotta Kikuko , Fujikado Takashi , Nishida Kohji 
Published: March 2019

AbstractBardet–Biedl syndrome (BBS), characterized by rod-cone dystrophy, postaxial polydactyly, central obesity, hypogonadism, renal abnormalities, and mental retardation, is a rare autosomal recessive disorder. To date, 21 causative genes have been reported. Here we describe a Japanese BBS patient with a novel compound heterozygous mutation in TTC8. To the best of our knowledge, this is the first description of a BBS patient with a mutation in the TTC8 gene in Japan.
Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
Authors: Zou Ting , Gao Lixiong , Zeng Yuxiao , Li Qiyou , Li Yijian , Chen Siyu , Hu Xisu , Chen Xi , Fu Caiyun , Xu Haiwei , Yin Zheng Qin 
Published: March 2019

AbstractStem cell therapy may replace lost photoreceptors and preserve residual photoreceptors during retinal degeneration (RD). Unfortunately, the degenerative microenvironment compromises the fate of grafted cells, demanding supplementary strategies for microenvironment regulation. Donor cells with both proper regeneration capability and intrinsic ability to improve microenvironment are highly desired. Here, we use cell surface markers (C-Kit+/SSEA4−) to effectively eliminate tumorigenic embryonic cells and enrich retinal progenitor cells (RPCs) from human embryonic stem cell (hESC)-derived retinal organoids, which, following subretinal transplantation into RD models of rats and mice, significantly improve vision and preserve the retinal structure. We characterize the pattern of integration and materials transfer following transplantation, which likely contribute to the rescued photoreceptors. Moreover, C-Kit+/SSEA4− cells suppress microglial activation, gliosis and the production of inflammatory mediators, thereby providing a healthier host microenvironment for the grafted cells and delaying RD. Therefore, C-Kit+/SSEA4− cells from hESC-derived retinal organoids are a promising therapeutic cell source.