bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Fasting Plasma Glucagon Level and Renal Function—A Cross-Sectional Study in Individuals With Type 2 Diabetes
Authors: Liu Jian-Jun , Liu Sylvia , Gurung Resham L , Chan Clara , Ang Keven , Tang Wern Ee , Tavintharan Subramaniam , Sum Chee Fang , Lim Su Chi 
Published: December 2018

Abstract

Background and Aim
The kidney is the main site for glucagon clearance. However, a recent study showed that hyperglucagonemia in patients with end-stage renal disease might not be caused by full-length intact glucagon. Additionally, the relationship between glucagon and renal function in early-stage chronic kidney disease (CKD) has not yet been characterized. We studied the association of fasting glucagon with renal function across a wide range of glomerular filtration rates (GFRs) in participants with type 2 diabetes.

Participants and Methods
326 participants with type 2 diabetes and renal function spanning CKD stage 1 to 5 were included in the present cross-sectional study. Fasting full-length plasma glucagon was quantified using a newly developed ELISA (Mercodia AB, Uppsala, Sweden).

Results
The fasting plasma glucagon level was elevated linearly from CKD stage 1 to 5 [from a median of 2.5 pM (interquartile range, 1.4 to 4.7) in CKD 1 to a median of 8.3 pM (interquartile range, 5.9 to 12.8) in CKD 5; P for trend &lt; 0.0001], from as early as CKD stage 2 compared with that in stage 1 (Bonferroni-corrected P &lt; 0.0001). The estimated GFR and homeostatic model of assessment–insulin resistance were the main determinants of the fasting glucagon level. These explained 14.3% and 10.3% of the glucagon variance, respectively. Albuminuria was not associated with fasting glucagon after adjustment for estimated GFR.

Conclusions
Fasting full-length glucagon was elevated linearly with the deterioration in renal function in individuals with type 2 diabetes, even in those with early CKD. In addition to renal function, insulin sensitivity was also a main determinant of glucagon variance.
Ένα Ψηφιακό Σενάριο για τις έννοιες Θερμότητα και Θερμοκρασία με την αξιοποίηση του προτύπου του μικρόκοσμου
Authors: Ιμβριώτη Δέσποινα 
Published: December 2018

Στο συγκεκριμένο άρθρο αναφέρονται συνοπτικά οι απόψεις που αποτυπώνονται στη βιβλιογραφία σχετικά με το μοντέλο / πρότυπο του μικρόκοσμου / της σωματιδιακής δομής της ύλης και την οπτικοποίησή του. Στη συνέχεια περιγράφεται το περιεχόμενο του ψηφιακού σεναρίου «Θερμότητα - Θερμοκρασία», οι διδακτικοί του στόχοι, η μεθοδολογία με βάση την οποία διαρθρώνεται, το πλάνο εφαρμογής του, οι διδακτικοί του πόροι, οι επεκτάσεις του. Το ψηφιακό σενάριο αξιοποιεί το πρότυπο του μικρόκοσμου για την ερμηνεία των φυσικών διαδικασιών θέρμανσης και ψύξης, όπως τις παρατηρούν οι μαθητές μέσω των πειραμάτων που εκτελούν με βάση το διδακτικό τους εγχειρίδιο. Περιλαμβάνονται οπτικοποιήσεις αυτού του προτύπου στις οποίες έχουν ληφθεί υπόψη -όσο ήταν δυνατό- οι προβληματισμοί που καταγράφονται στη διεθνή βιβλιογραφία προκειμένου να προσεγγίσουν οι μαθητές επιτυχέστερα τη σωματιδιακή δομή της ύλης αλλά και να αποφευχθεί η πρόκληση εσφαλμένων αντιλήψεων. Το σωματιδιακό πρότυπο στηρίζεται ιδιαίτερα από το συγκεκριμένο σενάριο καθώς αποτελεί ένα αξιόλογο μαθησιακό εργαλείο για την ερμηνεία του φυσικού κόσμου.
Εφαρμογή Ψηφιακών Διδακτικών Σεναρίων για το Γυμνάσιο από την πλατφόρμα Αίσωπος
Authors: Πανδή Μαρίνα , Στασινάκης Παναγιώτης 
Published: December 2018

Στην εργασία αυτή χρησιμοποιήσαμε διαφορετικά ψηφιακά σενάρια της πλατφόρμας «Αίσωπος», για να μελετήσουμε την εφαρμογή τους στη διδακτική πρακτική. Θέλαμε να διερευνήσουμε αν είναι αρκετοί οι διαθέσιμοι πόροι, ώστε να υλοποιηθούν τα επιλεγμένα σενάρια, και αν μπορούν αυτά να εφαρμοστούν στο σχολικό πλαίσιο. Επίσης επιδιώκαμε να εισάγουμε στη διδασκαλία μας ένα διαφορετικό τρόπο διδακτικής προσέγγισης, που να κινητοποιεί το ενδιαφέρον των μαθητών, αλλά και γιατί διέθεταν οργανωμένο και πρωτότυπο εκπαιδευτικό υλικό. Χρησιμοποιήσαμε τα σενάρια στα μαθήματα Βιολογία, και Γεωγραφία στην Α’ τάξη και Βιολογία στην Β’ και στη Γ’ τάξη. Οι διαπιστώσεις μας ήταν ότι συχνά η δυναμική της τάξης ανατρέπει ακόμα και τα πιο οργανωμένα σχέδια μαθήματος. Η δομή και οργάνωση των ψηφιακών σεναρίων μας επέτρεψαν να κάνουμε προσαρμογές ανάλογα με το χρόνο, και το έμψυχο υλικό της τάξης. Ο τρόπος δουλειάς των μαθητών, και ειδικότερα η ομαδοσυνεργατική ενίσχυσε θετικά το κλίμα της τάξης και συνετέλεσε στη διόρθωση λαθών στη διδασκαλία και την κατανόηση. Παράλληλα μας δόθηκε η δυνατότητα να αναδείξουμε και να διαχειριστούμε παρανοήσεις των μαθητών, ώστε να κάνουμε αποτελεσματικότερη διδασκαλία. Από την πλευρά της χρήσης των διαθέσιμων πόρων, σε κάποιες περιπτώσεις εγκατάστασης λογισμικού, αντιμετωπίσαμε πρόβλημα, ενώ εκτιμούμε ότι πριν την χρήση κάποιας διαδικτυακής πλατφόρμας για πρώτη φορά, θα πρέπει να υπάρχουν οδηγίες. Τέλος ως προς του πόρους θεωρούμε πως τα σενάρια, εύκολα μπορούν να ενταχθούν στη διδασκαλία., γιατί σχεδόν όλες οι σχολικές μονάδες διαθέτουν τέτοια βασική υποδομή.
The role of the home environment in neurocognitive development of children living in extreme poverty and with frequent illnesses: a cross-sectional study
Authors: Nampijja Margaret , Kizindo Robert , Apule Barbara , Lule Swaib , Muhangi Lawrence , Titman Andrew , Elliott Alison , Alcock Katie , Lewis Charlie 
Published: December 2018

Background:The home environment is reported to contribute significantly to children’s developing cognitive skills. However, it is not yet evident whether this role prevails in the context of extreme poverty and frequent ill-health. We therefore investigated the role of the home environment in Ugandan children taking into account the frequent infections and extreme poverty in which they lived.Methods:Cognitive abilities of 163 5-year-old children were assessed. Home environments of these children, their health status and family socioeconomic status (SES) were assessed respectively using the EC-HOME, anthropometry and illnesses, and traditional SES measures. Structural equation analyses compared five models on the influence of the home environment, SES, and child health on the cognitive scores.Results:The model in which the home environment mediates the combined influence of SES and child health on cognitive performance showed a particularly good fit to the data compared with the four alternative models, i.e. those in which the HOME, SES and health independently influence cognitive performance.Conclusions:Home environments providing cognitive stimulation can enable children to overcome effects of major adverse life experiences on cognitive development.
Drawing the letter
Authors: Reifenstein Tilo 
Published: December 2018

Abstract
Considering a drawn letter in one of Raymond Pettibon’s works, the article seeks to unravel the putatively facile distinction between drawing and writing. It asserts that the lack of iconic ‘motivation’ of alphabetic characters does not prevent them from harbouring further meanings that are indissociable from their form. The article thus questions the persistent legibility–visibility dichotomy in which writing’s letters are trapped between mere allography, whose graphic appearance beyond readability is irrelevant, and sign, whose semantic value is constituted multiply through its verbal and pictural qualities. Instead, this binary logic is displaced through the recognition of the mark that is both drawn and written, yet irreducible to either, and thus capable of pointing beyond itself and yet refer to its own form. In showing how the mark in Pettibon’s drawing may be read and viewed in multiple non-exclusive ways, the shared graphic capacity of writing and drawing is highlighted. The article promotes a perspective on writing that requires the acknowledgement of its graphic form without demanding a new dubious graphology. The writing of the article itself continuously engages its own inextricable entanglement in the issues discussed by accentuating the play that writing already entails if it is also seen and not merely read.
Drawn words: Pictographs in the Chinese language and visual culture
Authors: Buckingham-Hsiao Roland 
Published: December 2018

Abstract
This essay considers the presence of pictograms – drawings of things functioning as words – within the Chinese written language and beyond that, Chinese visual culture. It argues that a simplified understanding of the Chinese language has generally existed in the West and attempts instead to present a more accurate picture of Chinese written characters as comprised of picto- and ideo-graphic elements alongside phonetic ones. The origins of Chinese pictographs in drawn images are noted, examples of pictographs in Chinese visual culture are discussed, and the challenge that pictography presents to western models of the arbitrary linguistic sign is considered.
Drawing/writing/drawing
Authors: Maclagan David 
Published: December 2018

Abstract
Drawing and writing have a complex, sometimes incestuous, relationship. They are both taught to children, but in different, if overlapping, ways: writing is usually obliged to remain faithful, whereas drawing can break free. There is a no-man’s-land in between, where writing can look like drawing or vice versa, and there are instances where drawing seems to hark back to writing or to compete with it. This can take the form of ‘scripts’ whose legibility is open to question: sometimes they mimic an imaginary alphabet, at other times only the initiated can understand them. This essay offers a brief survey of this fascinating territory.
Exhibition Reviews
Authors: Veysi Mohsen , Blair Sarah , Raymond Hélène , Lichtsteiner Sibylle Hurschler 
Published: December 2018

Abstract
Drawing Through Time: Biennale Disegno, Rimini, 28 April–15 July 2018
Do the write thing 2: read between the lines (2018) Exhibition catalogue, christian berst art brut, Paris, 26 April–2 June. 195 pp., ISBN 979-1-09046-351-6, p/bk, 25 Euros
A Slice through the World: Contemporary Artists’ Drawings, curated by Kate Macfarlane and Stephenie Straine, Modern Art Oxford, Oxford, and the Drawing Room, London, 16 June–9 September 2018
Documentos etnográficos y dispositivos de memoria. La mirada etnográfica
Authors: Benzi Marina 
Published: December 2018

En el presente trabajo aspiramos abordar la miradaetnográfica de Alcides Greca en el filme El último malón (1917). Su mirada reposa en la comunidad mocoví de San Javier, provincia de Santa Fe, Argentina, en la primera mitad del siglo XX. Para ello, se rastrean los elementos políticos, ideológicos y académicos de la época que permiten ver y mostrar al aborigen como un sujeto de alteridad en un proceso de construcción y constitución de la República Argentina como un Estado–nación. Así también, consideramos los inicios del cine en la Argentina, el ejercicio de Greca como director del filme, y su posible labor como etnógrafo. Se destaca el valor del filme como potencial documento etnográfico y se realiza una aproximación al quehacer antropológico observando algunas similitudes.
Documentos etnográficos y dispositivos de memoria. El archivo audiovisual como dispositivo de memoria
Authors: Vallina Cecilia 
Published: December 2018

El artículo aborda cuáles son las dimensiones y categorías que se despliegan frente a un dispositivo de memoria como el recientemente creado Archivo Audiovisual de Juicios de Lesa Humanidad, en la ciudad de Santa Fe, Argentina. Este dispositivo transforma las condiciones de acceso y circulación de estos registros a un nuevo espacio en el que se alteran las ecuaciones usuales entre tiempo y memoria. En este sentido, se propone una reflexión sobre lo que implica la voluntad de construir archivos que contribuyan a inscribir estos juicios en el proceso de elaboración de una memoria social. ¿Cómo pueden ser leídas entonces las imágenes de estos juicios, cuál es su posibilidad de legibilidad desde el presente de una trama política, cultural y comunicacional, cómo se construye su significatividad? ¿Cuál es el rol de las instituciones que las preservan? ¿Cómo entrenamos nuestra mirada para leerlas desde nuestro presente?
El cine: entre el relato histórico, el arte y la política. El relato histórico en Juarez
Authors: Belmonte Grey Carlos A. 
Published: December 2018

Este artículo propone un análisis de la película Juarez, dirigida por William Dieterle en 1938 y exhibida en cines estadounidenses y mexicanos en 1939. La cinta fue producida por la Warner, que contrató a los renombrados actores Paul Muni y Bette Davis; tuvo el apoyo del presidente de México, Lázaro Cárdenas, quien puso a disposición de la producción documentos de Benito Juárez y entrevistas con testigos de la época, ofreció un recorrido por los lugares históricos y prestó el Palacio de Bellas Artes para la premier latinoamericana. Se propone debatir la idea de cine e historia: el cine histórico es una interpretación de la historia pasada y se convierte, al mismo tiempo, en un documento para la historia presente. En ese sentido, se plantean dos objetivos: mostrar cómo se construyó el relato histórico cinematográfico de la intervención francesa (1862–1867) y cómo vehiculizó los mensajes contra el nazismo, del New Deal y la lucha de la democracia.
El cine: entre el relato histórico, el arte y la política. Cine sin patrón:
Authors: Russo Pablo Mariano 
Published: December 2018

Las fábricas y empresas recuperadas atrajeron la curiosidad de periodistas locales y extranjeros, investigadores y cineastas que apuntaron sus cámaras al interior de los conflictos, creando representaciones, discursos y memorias sobre estos procesos históricos. Los audiovisuales que se ocupan de esta temática tienen, indefectiblemente, a los trabajadores y sus problemáticas como protagonistas. ¿De qué manera son representados en estos audiovisuales los trabajadores y trabajadoras que buscaron nuevas formas de producción y nuevas maneras de relacionarse a partir de la apropiación de las fábricas bajo autogestión? Indagamos aquí en Impreso en Chilavert, una de las experiencias más interesantes, por su apuesta estética y narrativa, por sus aciertos y fracasos, por sus búsquedas formales e informales, académicas y políticas, en relación a las piezas audiovisuales producidas sobre la temática.
A Hybrid Ant Colony System and Tabu Search algorithm for the production planning of dynamic cellular manufacturing systems while confronting uncertain costs
Authors: Delgoshaei Aidin , Mirzazadeh Abolfazl , Ali Ahad 
Published: December 2018

Highlights:

Cellular Manufacturing systems cover a wide range of industries.
Inflation rate can impose financial harms on cellular manufacturing systems.
The over-allocation of workers, which usually happens in dynamic systems, causes reduction of the system performance.
The proposed algorithm in this research can successfully schedule cellular systems to reduce system costs.

Goal:
The main aim is to determine the best trade-off values between in-house manufacturing and outsourcing, and track the impact of uncertain costs on gained schedules. To be more comprehensive, the performance of human resources is restricted and the partial demands are considered uncertain.
Design / Methodology / Approach:
In this paper a new method for minimizing human resource costs, including operating, salary, hiring, firing, and outsourcing in a dynamic cellular manufacturing system is presented where all system costs are uncertain during manufacturing periods and can be affected by inflation rate. For this purpose, a multi-period scheduling model that is flexible enough to use in real industries has been proposed. To solve the proposed model, a hybrid Ant Colony Optimization and the Tabu Search algorithm (ACTS) are proposed and the outcomes are compared with a Branch-and-Bound based algorithm.
Results:
Our findings showed that the inflation rate has significant effect on multi-period system planning. Moreover, utilizing system capability by the operator, for promoting and using temporary workers, can effectively reduce system costs. It is also found that workers’ performance has significant effect on total system costs.
Limitations of the investigation:
This research covers the cellular manufacturing systems.
Practical implications:
The algorithm is applied for 17 series of dataset that are found in the literature. The proposed algorithm can be easily applied in real industries.
Originality / Value:
The authors confirm that the current research and its results are original and have not been published before. The proposed algorithm is useful to schedule cellular manufacturing systems and analyse various production conditions.
Jurnalisme sebagai Arena Pertarungan Kepentingan: Telaah Teori Kebudayaan
Authors: Amirudin Amirudin 
Published: December 2018

This paper is a theoretical study of the use of cultural theory which played to explain journalism activities that just not an activity to provide accurate information in the public space. In an industrial context, in fact journalism activities has face any complex situasion. Now, the activities is no longer exclusively owned by journalists, but journalism is a kind of football arena that have some interest in it. To present news, journalists must be able to absorb various interest from various trajectories. There is a game metaphor that journalists must follow, and how journalist do "practice" the game in the field of contestation, which will be explored using Bourdieu's cultural theory,Through this article, I hope, it can contribute to how anthropology plays a role in developing media studies, and vice versa, it can be a trigger for how anthropologists should begin to enter cultural studies which are not just exotic and simple social units; but also entered the study arena into more complex social units, for example in media organizations
Impact of interactions between drugs and laboratory test results on diagnostic test interpretation – a systematic review
Authors: van Balveren Jasmijn A. , Verboeket-van de Venne Wilhelmine P.H.G. , Erdem-Eraslan Lale , de Graaf Albert J. , Loot Annemarieke E. , Musson Ruben E.A. , Oosterhuis Wytze P. , Schuijt Martin P. , van der Sijs Heleen , Verheul Rolf J. , de Wolf Holger K. , Kusters Ron , Hoedemakers Rein M.J. ,   on behalf of the Dutch Society for Clinical Chemistry and Laboratory Medicine, task group ‘SMILE’: Signaling Medication Interactions and Laboratory test Expert system
Published: December 2018

Abstract
Intake of drugs may influence the interpretation of laboratory test results. Knowledge and correct interpretation of possible drug-laboratory test interactions (DLTIs) is important for physicians, pharmacists and laboratory specialists. Laboratory results may be affected by analytical or physiological effects of medication. Failure to take into account the possible unintended influence of drug use on a laboratory test result may lead to incorrect diagnosis, incorrect treatment and unnecessary follow-up. The aim of this review is to give an overview of the literature investigating the clinical impact and use of DLTI decision support systems on laboratory test interpretation. Particular interactions were reported in a large number of articles, but they were fragmentarily described and some papers even reported contradictory findings. To provide an overview of information that clinicians and laboratory staff need to interpret test results, DLTI databases have been made by several groups. In a literature search, only four relevant studies have been found on DLTI decision support applications for laboratory test interpretation in clinical practice. These studies show a potential benefit of automated DLTI messages to physicians for the correct interpretation of laboratory test results. Physicians reported 30–100% usefulness of DLTI messages. In one study 74% of physicians sometimes even refrained from further additional examination. The benefit of decision support increases when a refined set of clinical rules is determined in cooperation with health care professionals. The prevalence of DLTIs is high in a broad range of combinations of laboratory tests and drugs and these frequently remain unrecognized.
Neonatal hemorrhagic shock as a consequence of ruptured velamentous vessels – a report of two cases
Authors: Blagaić Vladimir , Pleša Ivona , Stanojević Milan , Gović Alenka Akšamija 
Published: December 2018

Abstract

Background
The objective of the study was to present the rupture of velamentous vessels as a rare but dangerous complication of pregnancy associated with high neonatal risk. Diagnosis of velamentous insertion of umbilical vessels is important to recognize because of the possibility of their rupture during labor. If the condition remains unrecognized, the most important step during labor is prompt and timely treatment of the multidisciplinary team in order to reduce fetal and neonatal mortality and morbidity.

Case presentation
We present two cases of ruptured velamentous vessels, both with good outcomes: in the first case the baby was delivered vaginally after a spontaneous rupture of the velamentous vessels, and in the second case an emergency cesarean section was performed.

Conclusions
Although bleeding caused by the rupture of velamentous vessels is not frequent, the consequences can be serious. The proper diagnosis of the umbilical cord insertion is mandatory during the mid-trimester anomaly scan, but in most cases the condition remains unrecognized until delivery. In the case of a rupture, a prompt reaction of the medical team is crucial in order to save the baby. Sometimes only an urgent 0 Rh negative blood transfusion can avoid a poor neonatal outcome.
A practical approach to adjusting for population stratification in genome-wide association studies: principal components and propensity scores (PCAPS)
Authors: Zhao Huaqing , Mitra Nandita , Kanetsky Peter A. , Nathanson Katherine L. , Rebbeck Timothy R. 
Published: December 2018

Abstract
Genome-wide association studies (GWAS) are susceptible to bias due to population stratification (PS). The most widely used method to correct bias due to PS is principal components (PCs) analysis (PCA), but there is no objective method to guide which PCs to include as covariates. Often, the ten PCs with the highest eigenvalues are included to adjust for PS. This selection is arbitrary, and patterns of local linkage disequilibrium may affect PCA corrections. To address these limitations, we estimate genomic propensity scores based on all statistically significant PCs selected by the Tracy-Widom (TW) statistic. We compare a principal components and propensity scores (PCAPS) approach to PCA and EMMAX using simulated GWAS data under no, moderate, and severe PS. PCAPS reduced spurious genetic associations regardless of the degree of PS, resulting in odds ratio (OR) estimates closer to the true OR. We illustrate our PCAPS method using GWAS data from a study of testicular germ cell tumors. PCAPS provided a more conservative adjustment than PCA. Advantages of the PCAPS approach include reduction of bias compared to PCA, consistent selection of propensity scores to adjust for PS, the potential ability to handle outliers, and ease of implementation using existing software packages.