bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal responses to negative emotions and child externalizing behavior: Different relations for 5‐, 6‐, and 7‐year‐olds
Authors: Nelson Jackie A. , Boyer Brittany P. 
Published: March 2018

AbstractEmotional and behavioral maturity expectations increase as children transition to primary school; thus, maternal responses that support and encourage children's expression of negative emotion may not benefit school‐age children as much as preschoolers. The current study explored a change in the utility of these maternal responses among 187 families (62 5‐year‐olds, 75 6‐year‐olds, and 50 7‐year‐olds). Mothers reported on their responses to children's negative emotions and children's externalizing and internalizing behaviors at two time points over 1 year. Multiple group analysis within cross‐lagged path models revealed a positive association between non‐supportive maternal responses and later child externalizing behaviors among 5‐year‐olds. However, non‐supportive responses were related to decreases in externalizing behaviors among the 7‐year‐olds. Discrepant findings between the 5‐ and 7‐year‐olds may represent a developmental shift in the function of mothers' emotion socialization practices.
Social Innovation in Rural Regions: Urban Impulses and Cross‐Border Constellations of Actors
Authors: Noack Anika , Federwisch Tobias 
Published: March 2018

AbstractResearch on social innovation in rural regions is gaining momentum. However, the question where new impulses for innovation in rural regions are being created remains unanswered. This article argues that social innovation processes in rural regions can be inspired by cross‐border constellations of actors and do, at times, build on bodies of knowledge and practices widespread in urban areas. Ethnographic data from Germany's rural Eifel region in Rhineland‐Palatinate, Lower Lusatia, and the Uckermark region located in Brandenburg illustrates the way in which external urban factors and cross‐border constellations of actors can influence rural social innovation. Thereby, rural social innovation stimulates the intersection of rural and urban elements (strengthening rural‐urban relations) and the erosion of rural‐urban antagonisms.
Conditions and decisions of urban elementary teachers regarding instruction of STEM curriculum
Authors: Smith Erica L. , Parker Carolyn A. , McKinney David , Grigg Jeffrey 
Published: March 2018

AbstractThe study was situated in a National Science Foundation supported Math Science Partnership between a private university and an urban school district. This study sought to understand the decision‐making process of elementary teachers as they implement an integrated science, technology, engineering, and mathematics (STEM) curriculum in their classrooms and the interactions that occur between the teachers and curriculum during that process. This qualitative study utilized a comparative case study approach to understanding the decision‐making process of three elementary teachers enacting the same lesson. Analysis of the interactions revealed that the teachers' perceptions of student ability, their pedagogical design capacity, and time were influences that impacted implementation. These findings have implications for STEM‐focused professional development of elementary teachers.
Body‐based activities in secondary geometry: An analysis of learning and viewpoint
Authors: Smith Carmen Petrick 
Published: March 2018

AbstractBody‐based activities have the potential to support mathematics learning, but we know little about the impact they have in the classroom. This study compares high school geometry students learning through either body‐based or analogous non‐body‐based activities over the course of a two‐week unit on similarity. Pre‐ and post‐tests revealed that while students in both conditions showed gains in content area comprehension over the course of the study, the body‐based condition showed significantly greater gains. Further, there were differences in the language students used to describe the learning activities at the end of the unit that may have contributed to the differences in learning gains. The students in the body‐based condition included more mathematical and nonmathematical details in their recollections. Additionally, students in the body‐based condition were more likely to recall their experiences from a first‐person perspective, while students in the control condition were more likely to use a third‐person perspective.
Clinical significance of post‐prophylaxis cytomegalovirus infection in lung transplant recipients
Authors: Jaamei Nikta , Koutsokera Angela , Pasquier Jérôme , Mombelli Matteo , Meylan Pascal , Pascual Manuel , Aubert John‐David , Manuel Oriol 
Published: March 2018

AbstractCytomegalovirus (CMV) disease has been associated with the development of chronic lung allograft dysfunction (CLAD) after transplantation. However, the relevance of CMV replication occurring after the discontinuation of antiviral prophylaxis on the development of CLAD has not been fully established. Patients who underwent lung transplantation during 2004‐2014 were included. All patients received antiviral prophylaxis for 3‐6 months, followed by monitoring of CMV replication during the first year post‐transplantation (preemptive therapy). Risk factors for the development of CLAD were assessed by Cox models. A linear regression model with an interaction coefficient between time and CMV infection was used to evaluate the influence of CMV infection on the evolution of FEV1. Overall, 69 patients were included, 30/69 (43%) patients developed at least 1 episode of significant CMV infection, and 8/69 (11.5%) patients developed CMV disease. After a median follow‐up of 3.67 years, 25/69 (36%) patients developed CLAD and 14/69 (20%) patients died. In the univariate Cox analysis, significant CMV infection (HR 1.177, P = .698), CMV disease (HR 1.001, P = .998), and duration of CMV replication (HR 1.004, P = .758) were not associated with CLAD. Only bacterial pneumonia tended to be associated with CLAD in the multivariate model (HR 2.579, P = .062). We did not observe a significant interaction between CMV replication and evolution FEV1 (interaction coefficient 0.006, CI 95% [−0.084 to 0.096], P = .890). In this cohort of lung transplant recipients receiving antiviral prophylaxis and monitored by preemptive therapy post‐prophylaxis, CMV infection did not have impact on long‐term allograft lung function.
Sexual acquisition of HIV infection after solid organ transplantation: Late presentation and potentially fatal complications
Authors: Cristelli M.P. , Mazolin M.A. , Manzardo C. , Ribeiro M.S.J. , Cofán F. , Santos D.W.C. , Castel M.A. , Tedesco‐Silva H. , Moreno A. , Diekman F. , Miro J.M. , Medina‐Pestana J.O. 
Published: March 2018

AbstractIntroductionWhile the growing knowledge on HIV among solid organ transplant recipients (SOT) is limited to either pretransplant infection or allograft transmission, there are only sparse reports describing HIV‐infection after transplantation through sexual route, the primary mode of transmission in the general population.MethodsFrom two different centers, we report nine new cases of HIV infection in SOT recipients attributed to sexual acquisition: eight cases of kidney‐transplant recipients and one heart‐transplant recipient.FindingsThere were nine cases of post‐transplant HIV‐infection detected among 14 526 transplants performed 1998 to 2015. In 6/9 cases, infection was contracted 5 years after SOT. All but one patient had stable allograft function under immunosuppressive therapy. The main trigger to diagnosis was late CMV disease and sexually transmitted diseases; five patients had CDC‐stage 3 HIV infection. In 7/9 patients, virologic response and CD4 recovery were achieved within 3 months after starting antiretroviral therapy (ART). After an average of 3.6 years post diagnosis, 5/9 patients remained alive with well‐controlled infection and functioning allograft.ConclusionSexual acquisition of HIV infection after SOT represents a difficult challenge, as it may occur in any kind of transplant and at any time. The course of infection resembles that of the general population, with life‐threatening infectious complications, but good response to ART. Assessment of lifestyle and risk behavior is paramount, as indications may be not disclosed without direct questioning.
Cytidinediphosphate‐diacylglycerol synthase 5 is required for phospholipid homeostasis and is negatively involved in hyperosmotic stress tolerance
Authors: Hong Yue , Yuan Shu , Sun Linxiao , Wang Xuemin , Hong Yueyun 
Published: March 2018

SummaryCytidinediphosphate diacylglycerol synthase (CDS) uses phosphatidic acid (PA) and cytidinetriphosphate to produce cytidinediphosphate‐diacylglycerol, an intermediate for phosphatidylglycerol (PG) and phosphatidylinositol (PI) synthesis. This study shows that CDS5, one of the five CDSs of the Oryza sativa (rice) genome, has multifaceted effects on plant growth and stress responses. The loss of CDS5 resulted in a decrease in PG and PI levels, defective thylakoid membranes, pale leaves in seedlings and growth retardation. In addition, the loss of CDS5 led to an elevated PA level and enhanced hyperosmotic tolerance. The inhibition of phospholipase D (PLD)‐derived PA formation in cds5 restored the hyperosmotic stress tolerance of the mutant phenotype to that of the wild type, suggesting that CDS5 functions as a suppressor in PLD‐derived PA signaling and negatively affects hyperosmotic stress tolerance.
Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures, and altered inflammatory markers in pediatric cardiac surgery patients
Authors: Cholette Jill M. , Pietropaoli Anthony P. , Henrichs Kelly F. , Alfieris George M. , Powers Karen S. , Gensini Francisco , Rubenstein Jeffrey S. , Sweeney Dawn , Phipps Richard , Spinelli Sherry L. , Refaai Majed A. , Eaton Michael P. , Blumberg Neil 
Published: March 2018

BACKGROUNDThere are data suggesting that free hemoglobin (Hb), heme, and iron contribute to infection, thrombosis, multiorgan failure, and death in critically ill patients. These outcomes may be mitigated by haptoglobin.STUDY DESIGN AND METHODS164 consecutively treated children undergoing surgery for congenital heart disease were evaluated for associations between free Hb and haptoglobin and clinical outcomes, physiologic metrics, and biomarkers of inflammationRESULTSHigher perioperative free Hb levels (and lower haptoglobin levels) were associated with mortality, nosocomial infection, thrombosis, hours of intubation and inotropes, increased interleukin‐6, peak serum lactate levels, and lower nadir mean arterial pressures. The median free Hb in patients without infection (30 mg/dL; 29 interquartile range [IQR], 24‐52 mg/dL) was lower than in those who became infected (39 mg/dL; IQR, 33‐88 mg/ 31 dL; p = 0.0046). The median mechanical ventilation requirements were 19 (IQR, 7‐72) hours in patients with higher levels of haptoglobin versus 48 (IQR, 18‐144) hours in patients with lower levels (p = 0.0047). Transfusion dose, bypass duration, and complexity of surgery were all significantly correlated with Hb levels and haptoglobin levels. Multivariate analyses demonstrated that these variables were independently and significantly associated with outcomes.CONCLUSIONSElevated pre‐ and postoperative levels of free Hb and decreased levels of haptoglobin were associated with adverse clinical outcomes, inflammation, and unfavorable physiologic metrics. Transfusion, RACHS score, and duration of bypass were associated with increased free Hb and decreased haptoglobin. Further investigation of the role of hemolysis and haptoglobin as potential mediators or markers of outcomes is warranted.
Cold storage of platelets in platelet additive solution: an in vitro comparison of two Food and Drug Administration–approved collection and storage systems
Authors: Reddoch‐Cardenas Kristin M. , Montgomery Robbie K. , Lafleur Crystal B. , Peltier Grantham C. , Bynum James A. , Cap Andrew P. 
Published: March 2018

BACKGROUNDRefrigeration of platelets (PLTs) in a PLT additive solution (PAS) reduces PLT activation compared to storage in plasma and preserves function for at least 15 days. Currently only two PASs are licensed by the Food and Drug Administration, each for use with only one apheresis platform. In this study, we compared the metabolic, functional, and activation status of PLTs collected on a Trima apheresis collection system and stored refrigerated in Isoplate (ISO) PAS to PLTs collected on an Amicus collection system and stored refrigerated in Intersol (INT) PAS.STUDY DESIGN AND METHODSApheresis PLTs (n = 4‐7 donors) were collected on a Trima in ISO PAS or on an Amicus in INT PAS. PLTs were stored in a walk‐in refrigerator (1‐6°C) without agitation for long‐term storage. Bags were assayed at Days 1, 5, 10, and 15 of storage. Measurements included PLT counts, pH, aggregation response, rotational thromboelastometry, and activation markers.RESULTSCold‐stored Trima‐collected PLTs in ISO were slightly more hemostatic than Amicus‐collected PLTs in INT and displayed better adhesion to collagen under flow conditions. Amicus‐collected PLTs in INT showed increased microaggregate formation on Days 5 and 10 and a significant decrease in PLT count over storage. Trima‐collected PLTs in ISO displayed better clot strength than Amicus‐collected PLTs in INT.CONCLUSIONCompared to cold‐stored Amicus PLTs in INT, Trima PLTs in ISO display superior in vitro function and may be better suited for treatment of bleeding patients. Clinical studies are warranted to confirm these findings.
Evaluation of 5 methods for diagnosing failure of passive transfer in 160 Holstein calves
Authors: Zakian Amir , Nouri Mohammad , Rasooli Aria , Ghorbanpour Masoud , Constable Peter D. , Mohammad‐Sadegh Majid 
Published: March 2018

BackgroundInadequate absorption of colostral IgG1is termed failure of transfer of passive immunity (FTPI). Dairy calves withFTPIhave increased mortality and morbidity in their first 6 months of life.ObjectivesThis study compared the clinical performance of 5 methods for diagnosingFTPIin Holstein calves.MethodsAn observational study was performed using 160 Holstein heifer calves. Serum was harvested at 48 hours of age, andFTPIwas assessed using a digital Brix refractometer for total solids measurements, and digital refractometry and the biuret method to measure serum total protein (STP) concentrations. Serum gamma‐glutamyltransferase activity was measured with an automated analyzer, and serum IgG was measured with the zinc sulfate turbidity test and an enzyme‐linked immunosorbent assay. Diagnostic test performance was compared with that of the reference method (FTPIdefined as a serum total IgG concentration <10 g/L). Test performance was evaluated using the area under the receiver operating characteristic curve, the sensitivity, the specificity, and the positive likelihood ratio at the optimal test cut point, and by calculating the kappa coefficient.ResultsA serum digital Brix percentage of <7.8% and anSTPconcentration of <52 g/L measured using digital refractometry were the best methods to identify calves withFTPI. TheSTPconcentration measured with digital refractometry was 0.1 g/L lower than that measured with the biuret method.ConclusionsThe digital Brix refractometer and the digital refractometer provide accurate and clinically useful methods for identifying dairy calves withFTPI. In this study, the excellent performance of the Brix refractometer was likely due to the use of a fixed sample volume (200 μL) and a uniform sample temperature at the time of measurement.
Postoperative survival and early complications after intracranial surgery in dogs
Authors: Forward Alexander K. , Volk Holger A. , De Decker Steven 
Published: March 2018

AbstractObjectiveTo describe survival and early postoperative outcome after intracranial surgery in dogs.Study designRetrospective case series.AnimalsFifty client‐owned dogs that underwent intracranial surgery.MethodsRecords were searched and analyzed for dogs that underwent intracranial surgery between 2005 and 2015. Signalment, clinical presentation, neurological deficits, concurrent medical conditions, laboratory data, diagnosis, administration of perioperative glucocorticoids or antiepileptic drugs, and specific imaging, surgical, and anesthetic variables were recorded. Risk factors for survival, occurrence of postoperative complications, and hospitalization times were identified with univariate linear and logistic regression, followed by multivariable regression models.ResultsAll dogs were recovered with a specific protocol in an intensive care unit. Forty‐nine of 50 (98%) dogs survived the immediate postoperative period, and 46 of 50 (92%) survived to discharge. Early postoperative neurological deterioration was seen in 45% (22/49) of dogs, and a postoperative complication was diagnosed in 23 of 49 (47%). Nonneurological postoperative complications were seen in 9 of 49 (18%) dogs; the most common consisted of aspiration pneumonia (6/49, 12%). Among variables associated with outcomes, higher postoperative natremia (P = .023) and prolonged hospitalization (P = .024) were associated with the occurrence of postoperative, nonneurological complications.ConclusionThe short‐term survival rate of this population was excellent. About half of the dogs experienced neurologic deterioration and postoperative complications, and most resolved with treatment.Clinical significanceIn our clinical setting, intracranial surgery in dogs was associated with a high rate of survival and a low rate of severe postoperative complications.
Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review
Authors: Sarrafian Tiffany L. , Bodine Sue C. , Murphy Brian , Grayson J. Kevin , Stover Susan M. 
Published: March 2018

AbstractObjectiveLarge muscular or musculotendinous defects present a dilemma because of the inadequacies of current treatment strategies. Extracellular matrices (ECM) are potential clinically applicable regenerative biomaterials. This review summarizes information from the preclinical literature evaluating the use of ECM for muscle regeneration in animal models of volumetric muscle loss (VML).Study DesignLiterature review.Sample populationAnimal models of VML in which surgical repair was performed with an ECM product, with or without added cell populations.MethodsPubMed, Google Scholar, CAB abstracts, and Scopus were searched for preclinical studies using ECM in animal models of VML. The search terms “extracellular matrix,” “VML,” “muscle regeneration,” “cell seeded,” and “scaffold” identified 40 articles that met inclusion criteria of an animal model of VML in which surgical repair was performed with an ECM product, with or without added cell populations. Key skeletal muscle repair mechanisms and experimental findings on scaffold type, VML location, and experimental animal species were summarized.ConclusionsSatellite cells and basal lamina are key endogenous contributors to skeletal muscle regeneration. ECM as a dynamic tissue component may provide structural integrity, signaling molecules, and a 3‐dimensional topography conducive to muscle regeneration. Preclinical models of muscle repair most commonly used mice and rats (88%). Most experimental lesions were created in abdominal wall (33%), anterior tibialis (33%), latissimus dorsi (10%), or quadriceps (10%) muscles. Matrices varied markedly in source and preparation. Experimental outcomes of ECM and cell‐seeded ECM implantation for muscle regeneration in VML were highly variable and dependent on matrix tissue source, preparation method, and anatomic site of injury. Scar tissue formation likely contributes to load transfer. Nonappendicular lesions had better regenerative results compared with appendicular VML.Clinical significanceThe preponderance of current evidence supports the use of ECM for muscle defect repair only in specific instances, such as nonappendicular and/or partial‐thickness defects. Consequently, clinical use of ECM in veterinary patients requires careful consideration of the specific ECM product, lesion size and location, and loading circumstances.
Raccoon roundworm (Baylisascaris procyonis) as an occupational hazard: 2. Use of personal protective equipment and infection control practices among raccoon rehabilitators
Authors: Sapp S. G. H. , Murray B. , Hoover E. R. , Green G. T. , Yabsley M. J. 
Published: March 2018

SummaryBaylisascaris procyonis, the raccoon roundworm, is a zoonotic ascarid of importance to human and animal health. Wildlife rehabilitators who care for raccoons may be at an increased risk for exposure to the parasite, especially if proper precautions are not taken. In a wider effort to evaluate awareness regarding B. procyonis in the wildlife rehabilitation community, an online survey (38–39 questions) including questions about B. procyonis knowledge and attitudes was developed and administered to wildlife rehabilitators. To assess precautions taken among raccoon rehabilitators, participants who rehabilitated raccoons (n = 447) answered additional questions about use of personal protective equipment (PPE) and infection control practices (ICPs). Reported use of gloves was variable, but hand hygiene was generally consistent. Masks and gowns were seldom used. Part‐time or infrequent volunteers and rehabilitators located in the Central, Midwest and Southeast were significantly less likely to report consistent use of PPE. A total knowledge score from the survey was used to predict the likelihood of reporting the use of particular ICPs/PPE. Knowledge score had a highly significant but small effect on the likelihood of prophylactic use of anthelmintics, anthelmintics use for B. procyonis specifically, cleaning appropriately, and using species‐dedicated housing. Risk factor analysis was performed on data from a prior serologic survey to evaluate factors associated with exposure to B. procyonis and inconsistent handwashing after contact with live raccoons and their faeces; practising rehabilitation in B. procyonis hyperendemic regions and practising rehabilitation in the western region were significant risk factors for being seropositive. These data further demonstrate that correct PPE/ICPs are critical in mitigating the risk of B. procyonis exposure among raccoon rehabilitators and among other captive species.