bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of bivalirudin during percutaneous coronary intervention in high‐bleeding‐risk elderly patients with chronic total occlusion: A prospective randomized controlled trial
Authors: Wang Yong , Zhao Hong‐Wei , Wang Cheng‐Fu , Fan Chun‐Yu , Zhang Xiao‐Jiao , Zhu Yu , Luo De‐Feng , Yu Guo‐Ning , Hou Ai‐Jie , Luan Bo 
Published: February 2019

AbstractObjectivesTo assess the efficacy and safety of bivalirudin during percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) in high‐bleeding‐risk elderly patients.BackgroundBivalirudin reduces PCI‐related bleeding; however, its efficacy and safety in patients with CTO, especially elderly patients with a high bleeding risk, remain unclear.MethodsThis single‐center prospective randomized controlled trial assigned 123 high‐bleeding‐risk elderly patients with CTO to either the unfractionated heparin (UFH) group (n = 55) or the bivalirudin group (n = 68). The primary efficacy endpoint was the incidence of major adverse cardiac events (MACEs) during hospitalization and at the 6‐month follow‐up. The safety endpoint was bleeding or procedure (access)‐related complications after PCI.ResultsMACE incidence was 17.6% and 20.0% in the bivalirudin and UFH groups, respectively (P = 0.82). Bleeding Academic Research Consortium (BARC) type 1–2 bleeding events during hospitalization were comparable between the groups (UFH: 10.9% vs. bivalirudin: 8.8%, P = 0.77). No BARC type 3–5 bleeding events or severe procedure (access)‐related complications (subcutaneous hematoma >5 cm) occurred in either group. At the 6‐month follow‐up, MACE incidence was comparable between the groups (UFH: 3.6% vs. bivalirudin: 1.5%, P = 0.59). The Kaplan–Meier analysis revealed that MACE‐free survival rates were comparable between the groups (P = 0.43). One case of BARC type 3–5 bleeding (fatal intracranial hemorrhage) was observed in the UFH group at the 6‐month follow‐up.ConclusionsBivalirudin and UFH showed comparable efficacy and safety in elderly patients with a high bleeding risk, undergoing PCI for CTO lesions.
Long‐term trends of treatment effect of stenting or bypass surgery in patients with ostial or shaft left main coronary artery disease
Authors: Yoon Yong‐Hoon , Lee Pil Hyung , Ahn Jung‐Min , Kang Do‐Yoon , Park Hanbit , Kwon Osung , Lee Kyusup , Lee Seung‐Whan , Park Duk‐Woo , Park Seung‐Jung ,   for the IRIS‐MAIN Registry Investigators
Published: February 2019

AbstractBackgroundLittle is known about how the relative treatment effect of percutaneous coronary intervention (PCI) and coronary‐artery bypass grafting (CABG) on clinical outcomes in ostial or shaft left main coronary artery (LMCA) disease has evolved over time.MethodsThis study included 2,112 patients with ostial or shaft LMCA disease from IRIS‐MAIN registry who underwent PCI (n = 1,329) or CABG (n = 783). Patients were stratified by time period based on stent type availability: wave 1 (1995–2002, bare‐metal stent [BMS] era); wave 2 (2003–2006, first‐generation drug‐eluting stent [DES] era); and wave 3 (2007–2014, second‐generation DES era).ResultsCompared to CABG, PCI has been used more frequently from wave 1 to wave 3. PCI showed substantial improvements over time with respect to death (P for trend = 0.012); the composite of death, myocardial infarction (MI), or stroke (P for trend = 0.047); repeat revascularization (P for trend < 0.001); and major adverse cardiac and cerebrovascular events (MACCE; a composite of death, MI, stroke, or repeat revascularization) (P for trend < 0.001). By contrast, outcomes of CABG remained relatively stable over time. The gap between the treatment effects of CABG vs PCI for MACCE has narrowed over time; the adjusted hazard ratios for CABG compared to PCI during wave 1, 2, and 3 were 0.41 (95% confidence interval [CI]: 0.22–0.76), 0.47 (95% CI: 0.31–0.71), and 0.78 (95% CI: 0.50–1.20), respectively.ConclusionsIn patients with ostial or shaft LMCA disease, significant improvements in PCI outcomes resulted in a progressive decline in the gap between the outcomes of CABG and PCI.
Pulse‐steroid therapy in a 37‐year‐old man with acute motor and sensory axonal neuropathy: A case report
Authors: AlMohammedi Renad , AlJohani Samah , Bakheet Majid 
Published: February 2019

Key Clinical MessageWe report a case of 37‐year‐old man admitted with acute motor and sensory axonal neuropathy (AMSAN) which was treated with pulse‐steroid therapy after the plasmapheresis and intravascular immunoglobulin. The improvement of the symptoms of AMSAN after pulse‐steroid therapy may represent a therapeutic alternative for this variant of Guillain‐Barré syndrome.
Emphysematous cystitis in an elderly Japanese patient with type 2 diabetes mellitus
Authors: Yashima Hironori , Terasaki Michishige , Kushima Hideki , Hirano Tsutomu 
Published: February 2019

Key Clinical MessageWe report a rare but fatal case of emphysematous cystitis (EC) that presented as a typical image of gas bubbles within the urinary bladder wall on computed tomography (CT). This disease has a high mortality rate more than that reported previously based on recent literature review in Japan.
Sepsis after non‐perforated acute appendicitis
Authors: Faraji‐Goodarzi Mojgan 
Published: February 2019

Key Clinical MessageAppendicitis is a worm‐like appendage whose base is located on the posterior side of the inner cecum. Acute appendicitis is uncommon in children younger than 5 years old. The patient was a 1.5‐year‐old boy who was admitted to the hospital with a primary complaint of fever, diarrhea, and vomiting. A pathological report of acute puffiness appendicitis with peri appendicitis was confirmed. After two weeks of treatment, the patient was discharged with an good general condition.
Endoanchors under 3D image fusion for a type IA endoleak after EVAR
Authors: Tinelli Giovanni , De Nigris Francesca , Minelli Fabrizio , Flore Roberto , Santoliquido Angelo , Tshomba Yamume 
Published: February 2019

Key Clinical MessageThe Heli‐FX technique for type IA EL under 3D‐IF proved to be accurate in terms of EL channel vision and correct endoanchors deployment. The EL volume rendering constant view allowed a precise anchors fixation at the EL channel. 3D‐IF confirmed to be a valid help in orientation and navigation during endovascular aortic procedure.
Zirconium‐Based Materials for Electrochemical Energy Storage
Authors: Wang Jianda , Xiao Xiao , Lu Yao , Wang Yuyin , Chen Changyun , Pang Huan 
Published: February 2019

AbstractZirconium‐based materials have emerged as momentous candidates for next‐generation batteries and supercapacitors, owing to their distinctive chemical and physical properties. For instance, garnet‐Li7La3Zr2O12 can be used as an electrolyte for solid‐state lithium‐ion batteries, which delivers high bulk lithium‐ion conductivities in the range of 4.0×10−4 S cm−1 at 20 °C. We provide a comprehensive review of up‐to‐date research progress in zirconium‐based materials. The most recent advances in the field of zirconium‐based electrodes, electrolytes, coatings, and separator materials for rechargeable batteries and supercapacitors are summarized. Moreover, the electrochemical performances in terms of the specific capacity, rate capability, and cycling stability of zirconium‐based materials are reported. Finally, we discuss the limitations and challenges of zirconium‐based energy storage materials, followed by their present status and prospects for future research. We believe that this Review will be helpful for researchers and scientists who are seeking promising materials for batteries and supercapacitors.
Cathodic Behaviour of Dicationic Imidazolium Bromides: The Role of the Spacer
Authors: Rocco Daniele , Chiarotto Isabella , D'Anna Francesca , Mattiello Leonardo , Pandolfi Fabiana , Rizzo Carla , Feroci Marta 
Published: February 2019

AbstractThe cathodic reduction of dicationic imidazolium bromides, whose spacer is either an aliphatic chain or a xylyl group, leads to the formation of the corresponding N‐heterocyclic carbenes (NHCs), which were isolated as the corresponding thiones, after reaction with elemental sulfur. The behaviour of the dications was compared with the corresponding monocations. The behaviour of dicarbenes depends on the nature of the spacer. This study evidenced that dicarbenes deriving from xylyl dications are less stable than the corresponding aliphatic ones (giving lower yields in thiones), due to a debenzylation reaction. On the other hand, the yields in thiones starting from aliphatic dications are higher than the corresponding monocations, suggesting a cooperative reduction at the electrode of the two imidazolium moieties. The cathodic process was confirmed using the co‐electrogenerated hydrogen to reduce 2,2,2‐trifluoroacetophenone to the corresponding alcohol.
Synthesis and Structures of Stable PtII and PtIV Alkylidenes: Evidence for π‐Bonding and Relativistic Stabilization
Authors: Lapierre Etienne A. , Piers Warren E. , Lin Jian‐Bin , Gendy Chris 
Published: February 2019

AbstractIsolable cationic PtII and PtIV alkylidenes, proposed intermediates in catalytic organic transformations, are reported. The bonding in these species was probed by experimental, structural, spectroscopic, electrochemical and computational methods, providing direct evidence for π‐bonding, the often‐theorized relativistic stabilization of these species, and the influence of oxidation state.
True Blue Through Oxidation—A Thiaazulenic Heterophenoquinone as Electrochrome
Authors: Intorp Sebastian N. , Kushida Soh , Dmitrieva Evgenia , Popov Alexey A. , Rominger Frank , Freudenberg Jan , Hinkel Felix , Bunz Uwe H. F. 
Published: February 2019

AbstractA thiaazulenic quinone TAQ was synthesized and its optical and redox properties were investigated. The deep blue‐colored compound is readily and reversibly reduced to the colorless anionic state. Electrochromic films were prepared and showed reversible switching behavior for the anodically coloring and NIR electrochromic material.
Development of hair cell phenotype and calyx nerve terminals in the neonatal mouse utricle
Authors: Warchol Mark E. , Massoodnia Roxanna , Pujol Remy , Cox Brandon C. , Stone Jennifer S. 
Published: February 2019

AbstractThe vestibular organs of reptiles, birds, and mammals possess Type I and Type II sensory hair cells, which have distinct morphologies, physiology, and innervation. Little is known about how vestibular hair cells adopt a Type I or Type II identity or acquire proper innervation. One distinguishing marker is the transcription factor Sox2, which is expressed in all developing hair cells but persists only in Type II hair cells in maturity. We examined Sox2 expression and formation of afferent nerve terminals in mouse utricles between postnatal days 0 (P0) and P17. Between P3 and P14, many hair cells lost Sox2 immunoreactivity and the density of calyceal afferent nerve terminals (specific to Type I hair cells) increased in all regions of the utricle. At early time points, many calyces enclosed Sox2‐labeled hair cells, while some Sox2‐negative hair cells within the striola had not yet developed a calyx. These observations indicate that calyx maturation is not temporally correlated with loss of Sox2 expression in Type I hair cells. To determine which type(s) of hair cells are formed postnatally, we fate‐mapped neonatal supporting cells by injecting Plp‐CreER
T2:Rosa26
tdTomato mice with tamoxifen at P2 and P3. At P9, tdTomato‐positive hair cells were immature and not classifiable by type. At P30, tdTomato‐positive hair cells increased 1.8‐fold compared to P9, and 91% of tdTomato‐labeled hair cells were Type II. Our findings show that most neonatally‐derived hair cells become Type II, and many Type I hair cells (formed before P2) downregulate Sox2 and acquire calyces between P0 and P14.
The Influence of β‐Ammonium Substitution on the Reaction Kinetics of Aminooxy Condensations with Aldehydes and Ketones
Authors: Ogunwale Mumiye A. , Knipp Ralph J. , Evrard Clint N. , Thompson Lee M. , Nantz Michael H. , Fu Xiao‐An 
Published: February 2019

AbstractThe click‐chemistry capture of volatile aldehydes and ketones by ammonium aminooxy compounds has proven to be an efficient means of analyzing the carbonyl subset in complex mixtures, such as exhaled breath or environmental air. In this work, we examine the carbonyl condensation reaction kinetics of three aminooxy compounds with varying β‐ammonium ion substitution using Fourier transform ion cyclotron resonance mass spectrometry (FT‐ICR‐MS). We determined the activation energies for the reactions of the aminooxy compounds ATM, ADMH and AMAH with a panel of ketones and aldehydes that included acrolein and crotonaldehyde. The measurements indicate that the activation energies for the oximation reactions are quite low, less than 75 kJ mol−1. ADMH is observed to react the fastest with the carbonyls studied. We postulate this result may be attributed to the ADMH ammonium proton effecting a Brønsted‐Lowry acid‐catalyzed elimination of water during the rate‐determining step of oxime ether formation. A theoretical study of oxime ether formation is presented to explain the enhanced reactivity of ADMH relative to the tetraalkylammonium analog ATM.
Double‐Exchange Magnetic Interactions in High‐Temperature Ferromagnetic Iron Chalcogenide Monolayers
Authors: Kumar Sourabh , Mondal Chiranjit , Pathak Biswarup 
Published: February 2019

AbstractSmythite (
) is an iron‐based chalcogenide with a lamellar structure, different from the compositionally identical mineral greigite. Owing to their natural abundance, such transition metal chalcogenides are promising materials for low‐cost spintronic‐based devices. Herein, we discuss the charge transfer processes and complex magnetic ordering in a two‐dimensional (2D) smythite lattice. We find that
redox couple and complex magnetic ordering are governing factors in the charge transfer processes. A very strong ferromagnetic in‐lattice coupling is also observed, which is attributed to the presence of three Fe‐centres. To describe the magnetic behaviour molecular and periodic approaches have been considered. We found a substantial increase in Curie temperature with applied mechanical stress due to opening of the double exchange interaction angle. We also observe an in‐plane Jahn−Teller distortion, which is further confirmed by the spin−orbit counter plot. Our study thus provides an insight into the double exchange mechanism favoured by the
redox couple and results in a strong ferromagnetic ordering.
The Effect of the Phospholipid Bilayer Environment on Cholesterol Crystal Polymorphism
Authors: Varsano Neta , Beghi Fabio , Dadosh Tali , Elad Nadav , Pereiro Eva , Haran Gilad , Leiserowitz Leslie , Addadi Lia 
Published: February 2019

AbstractCholesterol crystallization from mixtures of unesterified cholesterol with phospholipids and cholesterol esters is believed to be a key event in atherosclerosis progression. Not much is understood, however, about the influence of the lipid environment on cholesterol crystallization. Here we study cholesterol monohydrate crystal formation from mixed bilayers with palmitoyl‐oleoyl‐phosphatidylcholine (POPC), dipalmitoyl‐phosphatidylcholine (DPPC) and sphingomyelin. We show that disordered phospholipids and sphingomyelin stabilize the formation of crystal plates of the triclinic cholesterol monohydrate polymorph, whereas saturated glycerolipids stabilize helical and tubular crystals of the metastable monoclinic polymorph. We followed the subsequent transformation of these helical crystals into the stable triclinic plates. Discovering the relations between membrane lipid composition and cholesterol crystal polymorphism may provide important clues to the understanding of cholesterol crystal formation in atherosclerosis.
6‐Phenylpyrrolocytidine: An Intrinsically Fluorescent, Environmentally Responsive Nucleoside Analogue
Authors: Cho Sung Ju , Ghorbani‐Choghamarani Arash , Saito Yoshio , Hudson Robert H.E. 
Published: February 2019

AbstractThe detailed synthetic protocols for the preparation of phosphoramidite reagents compatible with standard, automated oligonucleotide synthesis for the 2′‐deoxy‐ and ribo‐6‐phenylpyrrolocyitidine are reported. Each protocol starts with the parent nucleoside and prepares the 5′‐O‐dimethoxytrityl‐N4‐benzoyl‐5‐iodocytosine derivative for the nucleobase modification chemistry. The key step is the direct formation of 6‐phenylpyrrolocytosine aglycon via a sequential, one‐pot Pd‐catalyzed Sonogashira‐type cross‐ coupling followed by a 5‐endo‐dig cyclization. Subsequent standard transformations provide the deoxy‐ and 2′‐O‐tert‐butyldimethysilyl protected ribo‐ nucleoside phosphoramidite reagents. © 2019 by John Wiley & Sons, Inc.
An enhanced anonymous and unlinkable user authentication and key agreement protocol for TMIS by utilization of ECC
Authors: Ostad‐Sharif Arezou , Abbasinezhad‐Mood Dariush , Nikooghadam Morteza 
Published: February 2019

SummaryThe telecare medicine information systems (TMISs) not only help patients to receive incessant health care services but also assist the medical staffs to access patients' electronic health records anytime and from anywhere via Internet. Since the online communications are exposed to numerous security threats, the mutual authentication and key agreement between patients and the medical servers are of prime significance. During the recent years, various user authentication schemes have been suggested for the TMISs. Nonetheless, most of them are susceptible to some known attacks or have high computational cost. Newly, an effective remote user authentication and session key agreement protocol has been introduced by Ravanbakhsh and Nazari for health care systems. Besides the nice contributions of their work, we found that it has two security weaknesses, namely, known session‐specific temporary information attack and lack of perfect forward secrecy. As a result, to overcome these deficiencies, this paper suggests a novel anonymous and unlinkable user authentication and key agreement scheme for TMISs using the elliptic curve cryptosystem (ECC). We have evaluated the security of the proposed scheme by applying the automated validation of internet security protocols and applications (AVISPA) tool with the intention of indicating that our scheme can satisfy the vital security features. In addition, we have compared the proposed protocol with related schemes to show that it has a proper level of performance. The obtained results demonstrate that the new scheme is more preferable considering both efficiency and security criteria.
Spinal Cord Regeneration in Amphibians: A Historical Perspective
Authors: Freitas Polina D. , Yandulskaya Anastasia S. , Monaghan James R. 
Published: February 2019

AbstractIn some vertebrates, a grave injury to the central nervous system (CNS) results in functional restoration, rather than in permanent incapacitation. Understanding how these animals mount a regenerative response by activating resident CNS stem cell populations is of critical importance in regenerative biology. Amphibians are of a particular interest in the field because the regenerative ability is present throughout life in urodele species, but in anuran species it is lost during development. Studying amphibians, who transition from a regenerative to a nonregenerative state, could give insight into the loss of ability to recover from CNS damage in mammals. Here, we highlight the current knowledge of spinal cord regeneration across vertebrates and identify commonalities and differences in spinal cord regeneration between amphibians.
Long‐term sound and movement recording tags to study natural behavior and reaction to ship noise of seals
Authors: Mikkelsen Lonnie , Johnson Mark , Wisniewska Danuta Maria , van Neer Abbo , Siebert Ursula , Madsen Peter Teglberg , Teilmann Jonas 
Published: February 2019

Abstract

The impact of anthropogenic noise on marine fauna is of increasing conservation concern with vessel noise being one of the major contributors. Animals that rely on shallow coastal habitats may be especially vulnerable to this form of pollution.

Very limited information is available on how much noise from ship traffic individual animals experience, and how they may react to it due to a lack of suitable methods. To address this, we developed long‐duration audio and 3D‐movement tags (DTAGs) and deployed them on three harbor seals and two gray seals in the North Sea during 2015–2016.

These tags recorded sound, accelerometry, magnetometry, and pressure continuously for up to 21 days. GPS positions were also sampled for one seal continuously throughout the recording period. A separate tag, combining a camera and an accelerometer logger, was deployed on two harbor seals to visualize specific behaviors that helped interpret accelerometer signals in the DTAG data.

Combining data from depth, accelerometer, and audio sensors, we found that animals spent 6.6%–42.3% of the time hauled out (either on land or partly submerged), and 5.3%–12.4% of their at‐sea time resting at the sea bottom, while the remaining time was used for traveling, resting at surface, and foraging. Animals were exposed to audible vessel noise 2.2%–20.5% of their time when in water, and we demonstrate that interruption of functional behaviors (e.g., resting) in some cases coincides with high‐level vessel noise. Two‐thirds of the ship noise events were traceable by the AIS vessel tracking system, while one‐third comprised vessels without AIS.

This preliminary study demonstrates how concomitant long‐term continuous broadband on‐animal sound and movement recordings may be an important tool in future quantification of disturbance effects of anthropogenic activities at sea and assessment of long‐term population impacts on pinnipeds.
Development of optimization model for power system operation, outline of model design and verification of output
Authors: Honda Atsuo , Tezuka Koichiro , Okamura Tomohito , Kawamoto Kaoru , Shimizu Shoji , Harada Kohei , Tanabe Takahito , Shirakawa Tatsuya , Takahashi Tomohiro 
Published: February 2019

AbstractOsaka Gas Co., Ltd., jointly with NTT DATA Mathematical Systems Inc., has developed unit‐commitment model for optimizing dispatch of power generation units. Main purpose of this development is to simulate the future world of electric power system in accordance with national energy policy aiming to introduce large amount of renewable energy as well as vitalized cross‐border power exchange via PX market to enhance economically‐efficient power system operation. The model incorporates not only constraints of supply‐demand balance but also constraints of operating reserves, regulation reserves, maximum CO2‐emissions, etc.
MWCNT‐modified Electrode for Voltammetric Determination of Allura Red and Brilliant Blue FCF in Isotonic Sport Drinks
Authors: Sierra‐Rosales Paulina , Toledo‐Neira Carla , Ortúzar‐Salazar Pía , Squella Juan Arturo 
Published: February 2019

AbstractA fast and simple electrochemical sensor is presented for the determination of allura red and brilliant blue in isotonic sport drinks, using a glassy carbon electrode modified with multi‐walled carbon nanotubes. The electrochemical behavior of the colorants was studied by cyclic and differential pulse voltammetry in 0.1 M PBS, pH 7.0. The solution pH, the amount of nanomaterial on the surface of the electrode and the accumulation time of each colorant were optimized. Under the optimal conditions, the sensor exhibited a linear response to allura red and brilliant blue with detection limits of 7 μg L−1 and 52 μg L−1, respectively. The sensor was applied to the analysis of commercial isotonic sports drinks that contain individual or mixed colorants, showing good sensitivity and reproducibility. The results were compared with a chromatographic method showing that the levels of colorants are low and did not show a risk for a consumer's health.