bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do young adolescents with first-episode psychosis or ADHD show sensorimotor gating deficits?
Authors: Rydkjaer Jacob , Jepsen Jens Richardt Moellegaard , Pagsberg Anne Katrine , Fagerlund Birgitte , Glenthoej Birte Yding , Oranje Bob 
Published: March 2019

AbstractBackgroundEarly identification is important for patients with early-onset schizophrenia (SZ). Assessment of (candidate) endophenotypic markers for SZ, such as prepulse inhibition of the startle reflex (PPI), may help distinguish between the early-onset SZ and other psychiatric disorders. We explored whether PPI deficits usually seen in adult-onset SZ are present in young adolescents with either early-onset psychosis or attention deficit/hyperactivity disorder (ADHD).MethodsTwenty-five adolescents with first-episode, non-affective psychosis (FEP), 28 adolescents with ADHD and 43 healthy controls (HC), aged 12–17 years, were assessed with an auditory PPI paradigm.ResultsNo significant group differences were found in PPI. However, when the FEP group was divided into those already diagnosed with SZ (n= 13) and those without (N-SZ) (n= 12), and all four groups (SZ, N-SZ, ADHD and HC) were compared on percentage PPI in the 85/60 trials, significantly less PPI was found in patients with SZ than in the HC as well as the ADHD group. No significant group differences were found in explorative analyses on the other trial types. Additionally, startle magnitude was significantly higher in SZ than in N-SZ patients.ConclusionYoung adolescents with SZ showed sensorimotor gating deficits similar to those usually found in adults with SZ and had larger startle magnitude than patients with other types of non-affective early-onset psychosis. No sensorimotor gating deficits were found in adolescents with ADHD. Our findings support the theory that deficient PPI is endophenotypic for SZ.
WORLD TRADE, 1800-1938: A NEW SYNTHESIS
Authors: Federico Giovanni , Tena-Junguito Antonio 
Published: March 2019

AbstractThis paper outlines the development of world trade from 1800 to 1938. It relies on a newly compiled database, which, unlike previous works (e.g. Lewis 1981), reports series of imports and exports at current and constant prices and at current and constant (1913) borders for almost all existing polities. In the first sections, we outline the estimation methodology and assess the reliability of the series (now available athttp://www.uc3m.es/tradehist_db). World trade grew very fast throughout the «long» 19thcentury, but growth rates were higher before 1870. We measure the effects of war and the Great Depression on total trade and trade by continent and polity. Within this general upward trend, the performance of polities differed by geographical location, level of development, political status and factor endowment. Finally, we estimate trends in the share of primary products, which declined until World War One, with an acceleration in the second half of the 19thcentury.
Human rights in territorial peace agreements
Authors: Caspersen Nina 
Published: March 2019

AbstractJustice and peace are commonly seen as mutually reinforcing, and key international peacebuilding documents stress the importance of human rights. Is this apparent normative shift reflected in post-Cold War peace agreements? The existing literature is divided on this issue but has crucially treated both conflicts and peace agreements as aggregate categories. This article argues that the conflict type and the agreement's ‘core deal’ impact on the inclusion, or exclusion, of human rights provisions. Based on new coding of the 29 comprehensive agreements signed between 1990 and 2010, it compares agreements signed in territorial and non-territorial conflicts, and agreements with and without territorial autonomy. Qualitative Comparative Analysis is used to examine the different combinations of conditions that led to the inclusion of human rights. The analysis finds that agreements signed in territorial conflicts are significantly less likely to include effective human rights provisions, especially if the settlement includes territorial autonomy. Moreover, such provisions tend to be the result of high levels of international involvement, and the consequent lack of local commitment, or outright resistance, undermines their implementation. These findings point to important trade-offs between group rights and individual rights, and qualifies the notion of a liberal peace.
A Precise Method for Analysis of Elemental Distribution Inside Solute Clusters
Authors: Kitayama Takumi , Kozuka Masaya , Aruga Yasuhiro , Ichihara Chikara 
Published: March 2019

AbstractA procedure to analyze the elemental concentration distribution inside solute clusters after detection of clusters from atom probe tomography data set was proposed. We developed a code which can directly illustrate an average concentration profile inside a cluster even in the case of including various sizes of ellipsoidal clusters. The profile can be with respect to absolute distance and includes errors in each data point. The reliability of the developed code was verified by analyzing an artificial cluster model which has inhomogeneous elemental distribution. It was found that the precise estimation of cluster centroids is important and that the preferable conditions for targeting clusters are a detection efficiency of over 20%, over 30 atoms in a cluster on average, and over 100 atoms for each concentration data point.
Soft Socialism, Hard Realism: Partisan Song, Parody, and Intertextual Listening in Yugoslav Black Wave Film (1968–1972)
Authors: BEARD DANIJELA Š. 
Published: March 2019

AbstractIn this article I examine the use of music in modernist and politically engaged Yugoslav cinema of the 1960s through three groundbreaking black wave films: Želimir Žilnik'sRani radovi(Early Works, 1969), Dušan Makavejev'sWR: Misterije organizma(WR: Mysteries of the Organism, 1971), and Lazar Stojanović’sPlastični isus(Plastic Jesus, 1971). With a specific focus on the use of Partisan songs, I analyse how key political moments are encoded with new levels of meaning in these films, often through parody, irony, and satire. I identify a ‘sonic turn’ within black wave cinema and propose a method of ‘intertextual listening’ to reflect the importance of contextual knowledge in identifying and interpreting the cultural and political baggage trafficked into these movies. I ask how does music shape the discursive strategies and communicative potential of these films, rendering pre-composed music a powerful medium for social and political critique? And in what ways does film music construct the Yugoslav socialist experience more broadly, reflecting how ideals of reform socialism found musical expression in Yugoslavnovi film?
Music for International Solidarity: Performances of Race and Otherness in the German Democratic Republic
Authors: KELLY ELAINE 
Published: March 2019

AbstractCentral to the official identity of the German Democratic Republic (GDR) was the state's positioning of itself as the antifascist and anti-colonial other to West Germany. This claim was supported by the GDR's extensive programme of international solidarity, which was targeted at causes such as the anti-apartheid movement in South Africa. A paradox existed, however, between the vision of a universal proletariat that underpinned the discourse of solidarity and the decidedly more exclusive construct of socialist identity that was fostered in the GDR itself. In this article, I explore some of the processes of othering that were embedded in solidarity narratives by focusing on two quite contrasting musical outputs that were produced in the name of solidarity: the LPKämpfendes Vietnam, which was released on the Amiga record label in 1967, and the Deutsche Staatsoper's 1973 production of Ernst Hermann Meyer's anti-apartheid opera,Reiter der Nacht.
Remembrance of Things Past: Marxism and the Study of Popular Music
Authors: FRITH SIMON 
Published: March 2019

AbstractThis article considers the role of Marxism in the history of popular music studies. Its approach combines the sociology of knowledge with a personal memoir and its argument is that in becoming a field of scholarly interest popular music studies drew from both Marxist theoretical arguments about cultural ideology in the 1950s and 1960s and from rock writers’ arguments about the role of music in shaping socialist bohemianism in the 1960s and 1970s. To take popular music seriously academically meant taking it seriously politically. Once established as an academic subject, however, popular music studies were absorbed into both established music departments and vocational, commercial music courses. Marxist ideas and ideologues were largely irrelevant to the subsequent development of popular music studies as a scholarly field.
On the edges of the law: sex workers’ legal consciousness in England
Authors: Klambauer Eva 
Published: March 2019

AbstractIn England, sex workers are placed at the edges of the law. How the social and legal status of sex workers impacts on their perception of and interaction with the law in a semi-legal setting has not yet been explored. Drawing on fifty-two qualitative interviews with indoor and outdoor sex workers in England, this study investigates their disposition to the law, legality and the state. The commonalities and discrepancies between the experiences of indoor and outdoor sex workers reveal the influence of the combination of legal framework and social status on sex workers’ legal consciousness. This study finds that, even in a setting of semi-legality, sex workers attempt to avoid contact with state authorities. However, this aversion to the current law does not prevent them from making claims for legal change. Surprisingly, indoor and outdoor sex workers hold opposing views on the appropriate level of regulation and state involvement in the sex industry. Remarkably, although outdoor sex workers have more negative experiences with arbitrators of the law, they desire the law's protection. In contrast, indoor sex workers’ main grievance is for sex work to be a legitimate industry that can operate with only minimal state control. These differences in outdoor and indoor workers’ legal claims are explicable by sharp cleavages in social status, vulnerability and degree of criminalisation. These findings demonstrate that intra-group differences in the legal consciousness of marginalised groups are key to understanding the role of social and legal status in shaping legal claims.
A universal treaty for disasters? Remarks on the International Law Commission's Draft Articles on the Protection of Persons in the Event of Disasters
Authors: Bartolini Giulio 
Published: March 2019

AbstractThis article analyzes the Draft Articles on the Protection of Persons in the Event of Disasters adopted by the International Law Commission in 2016 in light of the recommendation made by the Commission to elaborate a convention on the basis of this project. While the latter proposal is still under evaluation by the United Nations General Assembly, which has recently decided to postpone its decision until 2020, such a potential outcome would represent a significant novelty in the area of disaster law, currently characterized by a fragmented legal framework and the lack of a universal flagship treaty. The Draft Articles thus aim to provide a systematization of the main legal issues relevant in the so-called disaster cycle, with solutions that accommodate the different interests of actors involved in a disaster scenario – namely, the affected State, external assisting actors and disaster victims – using a complex “checks and balances” approach.
Higher preprocedural fibrinogen levels are associated with aneurysm	sac regression after EVAR
Authors: Rašiová Mária , Koščo Martin , Špak Ľubomír , Moščovič Matej , Židzik Jozef , Slabá Eva , Habalová Viera , Farkašová Ľudmila , Hudák Marek , Tkáč Ivan 
Published: March 2019

Summary. Background: The aim of our study was to determine the diameter of the aneurysm sac 24 months after endovascular abdominal aortic aneurysm repair (EVAR); to identify factors associated with sac regression, and to determine the impact of sac regression on all-cause mortality during long-term follow-up. Patients and methods: We conducted a retrospective review of prospectively collected data from patients treated with EVAR between January, 2010 and July, 2016. Sac regression was defined as at least 5 mm decrease in aneurysm diameter in relation to the preprocedural diameter seen on computed tomography angiography. Sociodemographic information, comorbidities, treatment, laboratory parameters, selected anatomical and genetic factors were all analysed to determine their impact on sac regression. Results: During the study period, 124 patients with mean age of 71.2 ± 7.2 years met the inclusion criteria. Sac regression was found in 45.2% of patients. Higher preprocedural fibrinogen was found in patients with sac regression in comparison with patients with stable sac or sac expansion (3.84 g/l vs 3.47 g/l; p = 0.028). In multivariate analysis after adjustment for age, hypertension, sex, smoking, dyslipidaemia, volume and percentage of intraluminal thrombus higher fibrinogen was associated with an increased probability of sac regression (OR 2.47; 95% CI 1.29–4.72; p = 0.006). Persistent type II endoleak was associated with significantly lower probability of sac regression in univariate and multivariate analysis after adjustment for age, hypertension, sex, smoking and dyslipidaemia (OR 0.26; 95% CI 0.10–0.66; p = 0.004). Higher age was a significant predictor of sac regression in multivariate analysis after adjustment for hypertension, sex, smoking and dyslipidaemia (OR 1.07; 95% CI 1.02–1.14; p = 0.012). No difference was found between patient subgroups with and without sac regression in all-cause mortality during follow-up. Conclusions: Higher preprocedural fibrinogen, absence of persistent type II endoleak and higher age were predictive factors of aneurysm sac regression post-EVAR.
Acquired arteriovenous fistula of a finger
Authors: Rietig Roderich , Hudak Sarah , Hieronimus Anja , Lehn-Stefan Angela , Balletshofer Bernd , Häring Hans-Ulrich , Syha Roland , Randrianarisoa Elko 
Published: March 2019

Summary. Arteriovenous fistulae are defined as congenital or acquired abnormal direct communications between an artery and a vein leading to abnormal blood circulation. This report describes an unusual manifestation of an acquired peripheral arteriovenous fistula with a high shunt volume of 410 ml/min following a fracture of the 5th finger.
Going to Any Lengths: Solving for Fault Size and Fractal Slip for the 2016, Mw 6.2 Central Tottori Earthquake, Japan, Using a Transdimensional Inversion Scheme
Authors: Amey R. M. J. , Hooper A. , Morishita Y. 
Published: March 2019

AbstractMany earthquake properties, including slip, show self‐similar (fractal) features. We can incorporate self‐similarity into Bayesian slip inversions via von Karman correlation, so that the regularization applied is representative of observed fault features. In von Karman regularization, each slip patch has a relationship to every other patch. This means that von Karman regularization only has meaning when applied to patches that actually slipped; if applied to nonslipping patches, spurious slip can be added to meet the von Karman correlation criteria. Additionally, the fault size, usually chosen in advance, also affects the von Karman correlation lengths meaning that the final slip solution may be biased by initial geometry choices. Here we present a method for solving for the size of the fault plane during the slip inversion process, as well as slip, rake, and a hyperparameter controlling slip variance. We use a transdimensional Bayesian inversion scheme constrained by geodetic surface displacements and regularized using von Karman correlation. We use circular harmonics to solve for the size of the slipping area, to allow for a complex shape that is connected and continuous across the fault. We apply this method to the 2016 Mw 6.2 Central Tottori earthquake, Japan, constrained by interferometric synthetic aperture radar InSAR (Sentinel‐1 and ALOS‐2) and Global Navigation Satellite System data (GNSS). We find an area of slip extending from approximately 2‐ to 10‐km depth, with the slipping area elongated in the downdip direction. In contrast to some seismic studies, we find slip ruptured most of the seismogenic layer.
Explicit Representation of Grazing Activity in a Diagnostic Terrestrial Model: A Data‐Process Combined Scheme
Authors: Chen Yizhao , Ju Weimin , Mu Shaojie , Fei Xinran , Cheng Yuan , Propastin Pavel , Zhou Wei , Liao Cuijuan , Chen Luxiao , Tang Rongjun , Qi Jiaguo , Li Jianlong , Ruan Honghua 
Published: March 2019

AbstractGrazing activity is a fundamental behavior in pasture ecosystems and, globally, is a major disturbance that leads to destruction of terrestrial biomass. However, its impact on ecosystem C sequestration at large scales is not well understood due to its obvious anthropogenic property. In this study, we proposed a Data‐Process combined Grazing Scheme (DPGS) to quantify the regional grazing impact on ecosystem C sequestration in the typical pasture ecosystem, Temperate Eurasian Steppe. First, a pixel‐based livestock distribution map was generated based on fine‐scale (province/prefecture) inventory data using a resource‐oriented livestock distribution approach. Then the C consumption due to grazing (Closs,graze) was simulated by combining a late version of a remote‐sensing‐based terrestrial model, the Boreal Ecosystem Productivity Simulator and the Shiyomi grazing model. The modeled regional livestock density was evaluated against the Gridded Livestock of the World data set. The DPGS was able to reproduce the spatial distribution of livestock. Because extralarge herbivores (camel and horse) were involved in the calculation, the DPGS predicts higher livestock density than the Gridded Livestock of the World data set over 70% of the region. The modeledCloss,grazeand its seasonal variability were validated against multiple site‐based data sets. The results showed good agreements with the field observations ofCloss,graze. With further tests and data incorporations, this scheme has the potential to produce high‐resolution data sets of livestock distribution andCloss,grazeand become a useful diagnostic instrument for model evaluation, parameterization, and intercomparison.
Advancing environmental exposure assessment science to benefit society
Authors: Caplin Andrew , Ghandehari Masoud , Lim Chris , Glimcher Paul , Thurston George 
Published: March 2019

AbstractAwareness of the human health impacts of exposure to air pollution is growing rapidly. For example, it has become evident that the adverse health effects of air pollution are more pronounced in disadvantaged populations. Policymakers in many jurisdictions have responded to this evidence by enacting initiatives that lead to lower concentrations of air pollutants, such as urban traffic restrictions. In this review, we focus on the interplay between advances in environmental exposure assessment and developments in policy. We highlight recent progress in the granular measurement of air pollutants and individual-level exposures, and how this has enabled focused local policy actions. Finally, we detail an illustrative study designed to link individual-level health-relevant exposures with economic, behavioral, biological, familial, and environmental variables.
The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
Authors: Peng Yihan , Liao Qingchao , Tan Wei , Peng Changmin , Hu Zhaohua , Chen Yali , Li Zhuqing , Li Jing , Zhen Bei , Zhu Wenge , Li Xiangpan , Yao Yi , Song Qibin , Liu Chengsheng , Qi Xiangdong , He Fuchu , Pei Huadong 
Published: March 2019

AbstractPoly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations, but the underlying mechanism is not clear. Here, we report that the deubiquitylating enzyme USP15 affects cancer cell response to PARPi by regulating HR. Mechanistically, USP15 is recruited to DNA double-strand breaks (DSBs) by MDC1, which requires the FHA domain of MDC1 and phosphorylated Ser678 of USP15. Subsequently, USP15 deubiquitinates BARD1 BRCT domain, and promotes BARD1-HP1γ interaction, resulting in BRCA1/BARD1 retention at DSBs. USP15 knockout mice exhibit genomic instability in vivo. Furthermore, cancer-associated USP15 mutations, with decreased USP15-BARD1 interaction, increases PARP inhibitor sensitivity in cancer cells. Thus, our results identify a novel regulator of HR, which is a potential biomarker for therapeutic treatment using PARP inhibitors in cancers.
Developing a novel FRET assay, targeting the binding between Antizyme-AZIN
Authors: Ghalali Aram , Rice James M. , Kusztos Amanda , Jernigan Finith E. , Zetter Bruce R. , Rogers Michael S. 
Published: March 2019

AbstractAntizyme inhibitor (AZIN) stimulates cell proliferation by binding to and sequestering the cell cycle suppressor antizyme. Despite the important role of the antizyme-AZIN protein-protein interaction (PPI) in cell cycle regulation, there are no assays for directly measuring the binding of AZIN to antizyme that are amenable to high throughput screening. To address this problem, we developed and validated a novel antizyme-AZIN intramolecular FRET sensor using clover and mRuby2 fluorescent proteins. By introducing alanine mutations in the AZIN protein, we used this sensor to probe the PPI for key residues governing the binding interaction. We found that like many PPIs, the energy of the antizyme-AZIN binding interaction is distributed across many amino acid residues; mutation of individual residues did not have a significant effect on disrupting the PPI. We also examined the interaction between Clover-AZIN and antizyme-mRuby2 in cells. Evidence of a direct interaction between Clover-AZIN and antizyme-mRuby2 was observed within cells, validating the use of this FRET sensor for probing intracellular antizyme-AZIN PPI. In conclusion, we have developed and optimized a FRET sensor which can be adapted for high throughput screening of either in vitro or intracellular activity.
Light quality determines primary production in nutrient-poor small lakes
Authors: Tanabe Yukiko , Hori Makoto , Mizuno Akiko N. , Osono Takashi , Uchida Masaki , Kudoh Sakae , Yamamuro Masumi 
Published: March 2019

AbstractThe availability of nutrients for primary producers has long been thought to be the main limiting factor for primary productivity in nutrient-poor lake ecosystems. However, recent studies have indicated that the availability of light energy is also important. On the other hand, the amount of phototroph was reported to decrease in summer in Antarctic lakes, furthermore, the light environment underwater was shown containing high amount of ultraviolet energy in small Antarctic lakes. Here, we hypothesized that primary productivity is limited by not only nutrients and simple light quantity but also light quality in nutrient-poor lakes. Then, we investigate factors influencing primary production by benthic phototrophic communities in shallow nutrient-poor lakes. We examine the relationships between primary production in 17 Antarctic freshwater lakes and nutrient concentrations in lake and benthic water, temperature and light energy. Primary production is decreased by ultraviolet energy reaching the lake bed, showing that production is determined by light quality. We also correlate ultraviolet energy in lake water with the catchment area of each lake. Our results show that the underwater light environment has an important influence on primary production as a key limitation factor and is sensitive to materials in runoff from the surrounding environment for pristine lakes.