bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidimensional Associations between Cognition and Connectome Organization in Temporal Lobe Epilepsy
Authors: Rodríguez-Cruces Raúl , Bernhardt Boris C. , Concha Luis 
Published: June 2019

AbstractObjectiveTemporal lobe epilepsy (TLE) is known to affect large-scale structural networks and cognitive function in multiple domains. The study of complex relations between structural network organization and cognition requires comprehensive analytical methods and a shift towards multivariate techniques. The current work sought to identify multidimensional associations between cognitive performance and structural network topology in TLE.MethodsWe studied 34 drug-resistant TLE patients and 25 age- and sex-matched healthy controls. All participants underwent a comprehensive neurocognitive battery and multimodal MRI, allowing for large-scale connectomics, and morphological evaluation of subcortical and neocortical regions. Using canonical correlation analysis, we identified a multivariate mode that links cognitive performance to a brain structural network. Our approach was complemented by bootstrap-based clustering to derive cognitive subtypes and associated patterns of macroscale connectome anomalies.ResultsBoth methodologies provided converging evidence for a close coupling between cognitive impairments across multiple domains and large-scale structural network compromise. Cognitive classes presented with an increasing gradient of abnormalities (increasing cortical and subcortical atrophy and less efficient white matter connectome organization in patients with increasing degrees of cognitive impairments). Notably, network topology characterized better the cognitive performance than morphometric measures. Thus, connectome characteristics featured as important markers of network reorganization and loss of inter-regional connectivity.ConclusionsThe multivariate approach emphasized the close interplay between cognitive impairment and large-scale network anomalies in TLE. Our findings contribute to understand the complexity of structural connectivity regulating the heterogeneous cognitive deficits found in epilepsy
The Molecular and Microbial Microenvironments in Chronically Diseased Lungs
Authors: Melnik Alexey V. , Vázquez-Baeza Yoshiki , Aksenov Alexander A. , Hyde Embriette , McAvoy Andrew C , Wang Mingxun , da Silva Ricardo R. , Protsyuk Ivan , Wu Jason V. , Bouslimani Amina , Lim Yan Wei , Luzzatto-Knaan Tal , Comstock William , Quinn Robert A. , Wong Richard , Humphrey Greg , Ackermann Gail , Spivey Timothy , Brouha Sharon S. , Bandeira Nuno , Lin Grace Y. , Rohwer Forest , Conrad Douglas J. , Alexandrov Theodore , Knight Rob , Dorrestein Pieter C. , Garg Neha 
Published: June 2019

AbstractTo visualize the personalized distributions of pathogens, chemical environments including microbial metabolites, pharmaceuticals, and their metabolic products within and between human lungs afflicted with cystic fibrosis, we generated 3D microbiome and metabolome maps of six explanted lungs from three cystic fibrosis patients. These 3D spatial maps revealed that the chemical environments are variable between patients and within the lungs of each patient. Although the patients’ microbial ecosystems were defined by the dominant pathogen, their chemical diversity was not. Additionally, the chemical diversity between locales in lungs of the same individual sometimes exceeded inter-individual variation. Thus, the chemistry and microbiome of the explanted lungs appear to be not only personalized but also regiospecific. Previously undescribed analogs of microbial quinolones and antibiotic metabolites were also detected. Furthermore, mapping the chemical and microbial distributions allowed visualization of microbial community interactions, such as increased production of quorum sensing quinolones in locations where Pseudomonas was in contact with Staphylococcus and Granulicatella, consistent with in vitro observations of bacteria isolated from these patients. Visualization of microbe-metabolite associations within a host organ in early-stage CF disease in animal models will help elucidate a complex interplay between the presence of a given microbial structure, antibiotics, metabolism of antibiotics, microbial virulence factors, and host responses.ImportanceMicrobial infections are now recognized to be polymicrobial and personalized in nature. A comprehensive analysis and understanding of the factors underlying the polymicrobial and personalized nature of infections remains limited, especially in the context of the host. By visualizing microbiomes and metabolomes of diseased human lungs, we describe how different the chemical environments are between hosts that are dominated by the same pathogen and how community interactions shape the chemical environment, or vice versa. We highlight that three-dimensional organ mapping are hypothesis building tools that allow us to design mechanistic studies aimed at addressing microbial responses to other microbes, the host, and pharmaceutical drugs.
Genomes of Leishmania parasites directly sequenced from patients with visceral leishmaniasis in the Indian subcontinent
Authors: Domagalska Malgorzata A. , Imamura Hideo , Sanders Mandy , Van den Broeck Frederik , Raj Bhattarai Narayan , Vanaerschot Manu , Maes Ilse , D’Haenens Erika , Rai Keshav , Rijal Suman , Berriman Matthew , Cotton James A. , Dujardin Jean-Claude 
Published: June 2019

AbstractWhole genome sequencing (WGS) is increasingly used for molecular diagnosis and epidemiology of infectious diseases. Current Leishmania genomic studies rely on DNA extracted from cultured parasites, which might introduce sampling and biological biases into the subsequent analyses. Up to now, direct analysis of Leishmania genome in clinical samples is hampered by high levels of human DNA and large variation in parasite load in patient samples. Here, we present a method, based on target enrichment of Leishmania donovani DNA with Agilent SureSelect technology, that allows the analysis of Leishmania genomes directly in clinical samples. We validated our protocol with a set of artificially mixed samples, followed by the analysis of 63 clinical samples (bone marrow or spleen aspirates) from visceral leishmaniasis patients in Nepal. We were able to identify genotypes using a set of diagnostic SNPs in almost all of these samples (97%) and access comprehensive genome-wide information in most (83%). This allowed us to perform phylogenomic analysis, assess chromosome copy number and identify large copy number variants (CNVs). Pairwise comparisons between the parasite genomes in clinical samples and derived in vitro cultured promastigotes showed a lower aneuploidy in amastigotes as well as genomic differences, suggesting polyclonal infections in patients. Altogether our results underline the need for sequencing parasite genomes directly in the host samples.Author summaryVisceral leishmaniasis (VL) is caused by parasitic protozoa of the Leishmania donovani complex and is lethal in the absence of treatment. Whole Genome Sequencing (WGS) of L. donovani clinical isolates revealed hitherto cryptic population structure in the Indian Sub-Continent and provided insights into the epidemiology and potential mechanisms of drug resistance. However, several biases are likely introduced during the culture step. We report here the development of a method that allows determination of parasite genomes directly in clinical samples, and validate it on bone marrow and splenic aspirates of VL patients in Nepal. Our study sheds a new light on the biology of Leishmania in the human host: we found that intracellular parasites of the patients had very low levels of aneuploidy, in sharp contrast to the situation in cultivated isolates. Moreover, the observed differences in genomes between intracellular amastigotes of the patient and the derived cultured parasites suggests polyclonality of infections, with different clones dominating in clinical samples and in culture, likely due to fitness differences. We believe this method is most suitable for clinical studies and for molecular tracking in the context of elimination programs.
Can corporate philanthropy change consumers’ perceptions of Japanese multinationals and reduce animosity toward them?
Authors: Han C. Min , Kim Kyung Ae , Nam Hyojin 
Published: June 2019

PurposeThe purpose of this paper is to empirically investigate how corporate philanthropy (CP) can affect consumer perceptions of Japanese multinationals, for which there exists strong animosity in Asia, and how this animosity can be attenuated.Design/methodology/approachThe study first examines Japanese firms in China (Study 1) and then Japanese, European and local firms in Korea (Study 2).FindingsThe results suggest that CP activities can have a positive effect on the consumer recognition of company localness and they can also attenuate company animosity for foreign multinationals. In addition, the findings suggest that Japanese multinationals can benefit greatly from CP activities in Asia than for domestic and other foreign firms.Research limitations/implicationsThe study found that consumers do not have ethnocentric attribution biases in evaluations of CP activities by foreign multinationals, as suggested by attribution theory (Hewstone, 1990; Nisbett, 1971).Originality/valueThere is limited evidence supporting the effects of CP activities by foreign multinationals from a country of origin for which there exists strong animosity.
Conceptualising innovative price models: the RITE framework
Authors: Cöster Mathias , Iveroth Einar , Olve Nils-Göran , Petri Carl-Johan , Westelius Alf 
Published: June 2019

Purpose
The purpose of this paper is to lay a current, research-based foundation for investigation of the concept of innovative price models and its connection to business models.

Design/methodology/approach
The design is composed of a structured literature review of articles on price models published in 22 journals during 42 years. This then serves as a base for a subsequent conceptual discussion about the foundation of innovative price models.

Findings
The literature review yields only very few results that are loosely scattered across various areas and mostly without any kind of deeper exploration of the concept of price models. The paper therefore goes on to conceptually explore some fundamental conditions that might influence or even determine price models. The final outcome of this exploration is the relation, intention, technology and environment (RITE) framework that is a meta-model for conceptualising innovative price models.

Research limitations/implications
The literature review could include additional journals and areas, and empirical testing of the RITE framework as yet has been limited.

Practical implications
The RITE framework can be used by practitioners as a tool for investigating the potential and usefulness of developing the capability to handle innovative price models.

Originality/value
The RITE framework provides fundamental conditions, which influence, or even determine, how innovative price models are developed and applied.
How real are virtual experiences?
Authors: Trabelsi-Zoghlami Amira , Touzani Mourad 
Published: June 2019

PurposeThis paper aims to explore the virtual experience to understand its components and its effects on consumers’ real world.Design/methodology/approachOur approach relies on a rarely used projective method: “Album-on-Line” (AOL). This technique allows identifying consumers’ representations of their experience. It uses images to immerse participants in a virtual experience and to lead an individual reflection, then a group reflection.FindingsVirtual experiences have utilitarian, hedonic, psychological and social dimensions. When immersing in virtual experiences, consumers’ perception and consumption of products and services change. A projection occurs leading to an identification to virtual characters. This projection also leads to a consumption aiming at finding back the excitement and challenge lived during virtual experiences.Research limitations/implicationsThe main limitation of this research relates with the fuzzy distinction between the virtual and the electronic in consumers’ minds and even in the literature. Future work should propose a multidisciplinary definition of the virtual experience, considering its specificities and components.Practical implicationsThis research offers companies a better understanding of consumers’ motivations to live virtual experiences. It may bring insights on how to provide a more customized offering and a more adapted communication.Originality/valueCompared to previous work, the present research offers a better understanding of the components of online and offline virtual experiences by considering the virtual in its broadest meaning. The use of the AOL technique enabled a closer look at the specificities of the virtual experience as perceived by consumers. It was also possible to explore the “post-experience” stage by understanding the effect of virtual experiences on consumers’ perceptions and consumptions.
A framework to manage business-to-business branding strategies
Authors: Cassia Fabio , Magno Francesca 
Published: June 2019

PurposeIn the past decades, a growing body of studies has assessed the importance of brands in business-to-business (B2B) markets. However, until date, a comprehensive understanding of B2B branding strategies is lacking. Hence, the purpose of this paper is to develop a framework to select and manage B2B branding strategies.Design/methodology/approachThis study’s arguments are developed in line with MacInnis’s (2011) guidelines on conceptual contributions in marketing.FindingsAs a result of the arguments of this study, a framework is developed to identify the relationships between the types of B2B contexts and effective B2B branding strategies.Research limitations/implicationsDespite deriving from an extensive analysis of the literature, the framework requires future empirical validation. Moreover, the relationship linking a supplier to its customer is unique, and hence, each supplier should carefully select a branding strategy depending on the specific situation.Practical implicationsThe suggested framework provides actionable insights to inform managers’ decisions about the most effective B2B strategy for their firm, based on the relational complexity (number of customers, intensity of co-production and co-creation, and dyadic vs multiple-actor view).Originality/valueThis is the first study to provide a comprehensive model of B2B branding strategies. Therefore, it contributes to both advance theoretical knowledge and managerial practice.
Investigation of the flight behavior of a flare-stabilized projectile using 6DoF simulations coupled with CFD
Authors: Klatt Daniel , Proff Michael , Hruschka Robert 
Published: June 2019

Purpose
The present work aims to investigate the capabilities of accurately predicting the six-degrees-of-freedom (6DoF) trajectory and the flight behavior of a flare-stabilized projectile using computational fluid dynamics (CFD) and rigid body dynamics (RBD) methods.

Design/methodology/approach
Two different approaches are compared for calculating the trajectory. First, the complete matrix of static and dynamic aerodynamic coefficients for the projectile is determined using static and dynamic CFD methods. This discrete database and the data extracted from free-flight experiments are used to simulate flight trajectories with an in-house developed 6DoF solver. Second, the trajectories are simulated solving the 6DoF motion equations directly coupled with time resolved CFD methods.

Findings
Virtual fly-out simulations using RBD/CFD coupled simulation methods well reproduce the motion behavior shown by the experimental free-flight data. However, using the discrete database of aerodynamic coefficients derived from CFD simulations shows a slightly different flight behavior.

Originality/value
A discrepancy between CFD 6DoF/RBD simulations and results obtained by the MATLAB 6DoF-solver based on discrete CFD data matrices is shown. It is assumed that not all dynamic effects on the aerodynamics of the projectile are captured by the determination of the force and moment coefficients with CFD simulations based on the classical aerodynamic coefficient decomposition.
Numerical and experimental investigations of buffet on a diamond airfoil designed for space launcher applications
Authors: Dumon Jéromine , Bury Yannick , Gourdain Nicolas , Michel Laurent 
Published: June 2019

Purpose
The development of reusable space launchers requires a comprehensive knowledge of transonic flow effects on the launcher structure, such as buffet. Indeed, the mechanical integrity of the launcher can be compromised by shock wave/boundary layer interactions, that induce lateral forces responsible for plunging and pitching moments.

Design/methodology/approach
This paper aims to report numerical and experimental investigations on the aerodynamic and aeroelastic behavior of a diamond airfoil, designed for microsatellite-dedicated launchers, with a particular interest for the fluid/structure interaction during buffeting. Experimental investigations based on Schlieren visualizations are conducted in a transonic wind tunnel and are then compared with numerical predictions based on unsteady Reynolds averaged Navier–Stokes and large eddy simulation (LES) approaches. The effect of buffeting on the structure is finally studied by solving the equation of the dynamics.

Findings
Buffeting is both experimentally and numerically revealed. Experiments highlight 3D oscillations of the shock wave in the manner of a wind-flapping flag. LES computations identify a lambda-shaped shock wave foot width oscillations, which noticeably impact aerodynamic loads. At last, the experiments highlight the chaotic behavior of the shock wave as it shifts from an oscillatory periodic to an erratic 3D flapping state. Fluid structure computations show that the aerodynamic response of the airfoil tends to damp the structural vibrations and to mitigate the effect of buffeting.

Originality/value
While buffeting has been extensively studied for classical supercritical profiles, this study focuses on diamond airfoils. Moreover, a fluid structure computation has been conducted to point out the effect of buffeting.
Unsteady separated stagnation-point flow and heat transfer past a stretching/shrinking sheet in a copper-water nanofluid
Authors: Roşca Natalia C. , Roşca Alin V. , Pop Ioan 
Published: June 2019

Purpose
The purpose of this paper is to theoretically investigate the unsteady separated stagnation-point flow and heat transfer past an impermeable stretching/shrinking sheet in a copper (Cu)-water nanofluid using the mathematical nanofluid model proposed by Tiwari and Das.

Design/methodology/approach
A similarity transformation is used to reduce the governing partial differential equations to a set of nonlinear ordinary (similarity) differential equations which are then solved numerically using the function bvp4c from Matlab for different values of the governing parameters.

Findings
It is found that the solution is unique for stretching case; however, multiple (dual) solutions exist for the shrinking case.

Originality/value
The authors believe that all numerical results are new and original, and have not been published elsewhere.
Exploration of particle shape effect on Cu-H2O nanoparticles over a moving plate
Authors: K. Ganesh Kumar , Ali J. Chamkha , B.C. Prasannakumara , A.M. Jyothi 
Published: June 2019

Purpose
This paper aims to explore particle shape effect on Cu-H2O nanoparticles over a moving plate in the presence of nonlinear thermal radiation. To characterize the effect, particle shape and viscous dissipation are considered. Convergent solutions for the resulting nonlinear systems are derived and the effects of embedded parameters of interest on velocity and temperature field are examined.

Design/methodology/approach
The Runge–Kutta–Fehlberg fourth-fifth order method along with shooting technique is used to solve the governing equations (6) and (7) with boundary conditions (8). A suitable finite value of η∞ is considered in such a way that the boundary conditions are satisfied asymptotically.

Findings
The results show an increase in both the heat transfer and thermodynamic performance of the system. However, among the three nanoparticle shapes, disk shape exhibited better heat transfer characteristics and heat transfer rate. On the other hand, the velocity profile enhances with increasing values of ϕ in the first solution, but the opposite trend was found in the second solution.

Originality/value
The present paper deals with an exploration of particle shape effect on Cu-H2O nanoparticles over a moving plate in the presence of nonlinear thermal radiation. To characterize the effect, particle shape and viscous dissipation are considered. Convergent solutions for the resulting nonlinear systems are derived and the effects of embedded parameters of interest on velocity and temperature field are examined. The skin friction coefficient and Nusselt number are numerically tabulated and discussed. The results show an increase in both heat transfer and thermodynamic performance of the system. However, among the three nanoparticle shapes, disk shape exhibited better heat-transfer characteristics and heat-transfer rate. On the other hand, the velocity profile enhances with increasing values of ϕ in the first solution, but the opposite trend was found in the second solution.
Significance of activation energy in stratified flow of tangent hyperbolic fluid
Authors: Jabeen Sumaira , Hayat Tasawar , Qayyum Sumaira , Alsaedi Ahmed 
Published: June 2019

Purpose
The purpose of this paper is to address double stratification and activation energy in flow of tangent hyperbolic fluid. Flow is induced by non-linear stretching sheet of variable thickness. Heat flux by Cattaneo–Christov theory is implemented.

Design/methodology/approach
Non-linear system is computed for the convergent solutions. Attention is particularly focused to the velocity, temperature and concentration.

Findings
It is found that temperature and thermal layer thickness are decreased for larger stratification.

Originality/value
In view of aforementioned communication, the aim of the present study is fourfold: First, to inspect stagnation point flow of tangent hyperbolic liquid by a stretched sheet; second, to discuss effect of non-Fourier heat flux and double stratification; third, to investigate activation energy; and fourth, to examine variable thickness effect.