bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Donor-Transmitted Non-Small Cell Lung Cancer After Liver Transplantation: An Unwelcome Guest
Authors: Sonbol Mohamad B. , Halling Kevin C. , Douglas David D. , Ross Helen J. 
Published: February 2019

Abstract
Cancer transmission with organ donation has been previously reported with a variety of malignancies and organ transplants. The risk of transmission through organ transplantation from donors with a history of previously treated malignancies has been addressed by guidelines from transplant societies. Herein, we report a case of a patient who developed lung cancer confined to the liver after liver transplantation with no known history of malignancy in the donor. The suspicion of donor origin arose after positron emission tomography-computerized tomography scan showed metastatic lung cancer only involving the transplanted liver without a primary focus. Genetic analysis of the malignant cells confirmed donor origin of the cancer.
Entre Pais e Filhos: Encontros com a Cultura dos Videogames
Authors: Kroeff Renata Fischer da Silveira , Gavillon Póti Quartiero , Carangache Kijner Lígia , Maraschin Cleci 
Published: February 2019

Os videogames têm se constituído como um objeto de estudo para diversas áreas de conhecimento, criando um campo de pesquisa heterogêneo e com controvérsias relacionadas a aspectos positivos e negativos sobre as experiências de jogo. Com sua popularização no Brasil a partir da década de 1970, atualmente existe uma geração de adultos que cresceu jogando jogos digitais. O presente estudo visa abordar o que acontece quanto essa geração de jogadores constitui família e segue jogando videogames, agora com seus filhos. A estratégia metodológica escolhida consistiu na realização de entrevistas com pais e mães que jogam videogame com seus filhos. A pesquisa teve a participação de oito pais e duas mães. A estratégia metodológica escolhida, assim como a análise dos registros das entrevistas seguiu a abordagem sistêmica dos estudos da família e dos estudos da cognição enativa. Tal aporte teórico embasa nossa compreensão dos resultados da pesquisa. Em relação a decisões quanto ao acesso dos filhos aos jogos, o conhecimento empírico sobre a experiência de jogar videogame pareceu ser mais considerado do que o conhecimento conceitual-declarativo ao qual os participantes têm acesso na cultura. Observou-se que práticas envolvendo os videogames podem envolver formas interessantes de socialização em família e em outros contextos sociais.
Non-surgical approach for repairing perforations of pars tensa in tympanic membrane using TCA cauterization
Authors: Gaur Sushil , Patel Monika , Hirdesh Prince , Singh Vandana 
Published: February 2019

<p class="abstract"><strong>Background:</strong> Tympanic membrane perforations occurring due to mucosal COM usually require surgical interventions for repair (myringoplasty or tympanoplasty) depending on the size and site of the perforation and the ossicular chain continuity. Various studies have shown TCA cautery as an efficacious non surgical method for repairing small and medium sized TM perforations. This technique was successfully used and popularized for repairing small and medium sized perforations by Derlacki in 1953.</p><p class="abstract"><strong>Methods:</strong> In this study we included dry pars tensa perforations in 100 patients occurring due to trauma or unresolved cases after inflammation/infection of middle ear. 50% w/v trichloro acetic acid was used for a maximum number of 5 applications at the margins of the perforations which were followed up for the next one year. </p><p class="abstract"><strong>Results:</strong> In this study, involving a total of 125 perforations (75 unilateral and 50 bilateral), success rate was high among the patients with traumatic perforations and small sized perforations while a few number of perforations only reduced in size, which were later corrected with surgical approaches (myringoplasty/tympanoplasty). The overall success rate achieved in this study was 72.16%.</p><p class="abstract"><strong>Conclusions:</strong> Though there are various materials and methods available for this procedure, the principle remains the same. This technique should be attempted for patients that fit the criteria for undergoing this procedure before being undertaken for surgical approaches to minimize the risks and cost burden associated with surgery and anesthesia.</p>
Assessment of Ponseti technique of manipulation and serial casting in idiopathic clubfoot
Authors: Khazi Syed Asif Hussain , Koppolu Kanthi Kiran Kumar , Baroothu Yakub , Chodavarapu Lalith Mohan 
Published: February 2019

<p class="abstract"><strong>Background:</strong> Congenital talipes equinovarus is one of the commonest congenital foot deformities. Ponseti technique of treatment of clubfoot has gained popularity in the last few decades. Feet treated by Ponseti technique are supple, flexible and pain free. We have treated congenital idiopathic clubfoot with Ponseti technique at our institute and present our results.</p><p class="abstract"><strong>Methods:</strong> Forty eight feet in thirty children with clubfoot were treated by Ponseti technique in our institute. The study was conducted from December 2013 to December 2015. Parents were counselled regarding treatment protocol and maintenance with bracing was closely monitored. Each child was followed up for a minimum of six months. Pirani score was used to objectively document progress of treatment.<strong></strong></p><p class="abstract"><strong>Results:</strong> The average number of casts required for complete correction was 6.6. 38% feet required tendoachilles tenotomy. Higher the initial Pirani score, more number of casts were required to achieve full correction. Number of casts needed for complete correction did not correlate to time of presentation.</p><p class="abstract"><strong>Conclusions:</strong> Ponseti method is very effective in correcting congenital idiopathic clubfoot deformity. It’s easy to learn, is inexpensive and can completely correct the deformity. In developing nations, well trained Orthopaedic surgeons can treat these children effectively and decrease disabled population.</p><p class="abstract"> </p>
Globalización y regionalización en la economía política internacional contemporánea: aportes para nuevas teorizaciones sobre las regiones fronterizas
Authors: Bernal Meza Raul 
Published: February 2019

Con excepción o en presencia de relaciones de conflicto entre Estados sudamericanos, las regiones fronterizas son consideradas áreas de intercambio, interconexión, integración y cooperación. Estas constituyen espacios de un tipo de regionalismo específico, el regionalismo fronterizoo regionalismo de fronteras, inscrito en el concepto más abarcador de regionalismoque, como tal, forma parte de los procesos contemporáneos que se dan en la economía política internacional. Con base en esta visión, el objetivo del artículo es aportar elementos analíticos y conceptuales para la teorización sobre esta moderna expresión del regionalismo. Se concluye que el regionalismo de integración fronteriza, en el caso de países en desarrollo, depende también de dinámicas derivadas del carácter de economías extrovertidas, que forman parte de nuevos procesos y espacios de regionalización.
Preliminary standardization of consonant-vowel in noise test in normal Persian speaking children
Authors: Mehrkian Saeideh , Fadaie Elahe , Jalilzadeh Afshari Parisa , Bakhshi Enayatollah 
Published: February 2019

Background and Aim: Children have more dif­ficulty in understanding speech in noisy envi­ronment than adults. Different tests are available for evaluation of speech perception ability in noise in children, each examines different levels of auditory system. The present study aimed to obtain normative data for consonant-vowel in noise test for 8–12 years old Persian-speaking children.
Methods: A hundred and sixty children were selected in five age range groups of 8 to 12 years old (32 children in each age range) with normal hearing from school students in Tehran. The audiometry test was performed in octave interval between 500–4000 Hz. Then the con­sonant-vowel test was first performed in silence and then in signal-to-noise ratios (SNRs) of +12, +6, 0, −6, −12, at the listening comfort lev­el and randomly in children ears.
Results: There were significant differences bet­ween age range of 8 and 9 years with other age groups in the SNR of −12. There was a signi­ficant difference in all children between the scores of left and right ears in −12, −6, 0 SNRs (p < 0.05). However, there was no specific
pattern in each age group. The results showed that with increasing SNR, the scores of rec­ognition of the syllables increased. Sex had no effect on consonant-vowel recognition in the presence of noise.
Conclusion: Recognition of the consonant-vowel in high SNR in both ears is stable before age 8, and this stability in the low signal-to-noise ratio is higher at around the age of 10.
COMPETITIVIDADE E EVOLUÇÃO DA BOVINOCULTURA DE CORTE NO ESTADO DA BAHIA: UM ESTUDO BASEADO EM RECURSOS ESTRATÉGICOS
Authors: Pedreira Adriana Calmon de Brito , Monteiro Augusto de Oliveira 
Published: February 2019

Este trabalho apresenta um estudo da competitividade e desempenho da bovinocultura de corte no Estado da Bahia com base na Resources Based View – RBV. Analisa as
características gerais do setor, as possibilidades de inovação nos contextos tecnológico, or
HUBUNGAN VISUS DENGAN RISIKO JATUH PADA LANSIA DI KELURAHAN BACIRO YOGYAKARTA
Authors: Rigenastiti Amadea , Widagdo The Maria Meiwati , Suryanto Yanti Ivana 
Published: February 2019

Background: The aging process causes changes of physiological and psychosocial functions. The percentage of older people population in Yogyakarta Province in 2015 was 13,49%, the highest in Indonesia. The increased number of older people is followed by the increased number of problems in older people. One of the most common problems of older people is falls. Risk of falls consists of intrinsic and extrinsic factors. Visual acuity is a part of the intrinsic factor of risk of falls in the older people.
Objective: To find out the correlation between visual acuity and the risk of falls of older people in Baciro Village Yogyakarta.

Methods: The research method was observational-analytic with cross sectional design. Researchers took samples in Baciro Village Yogyakarta. The inclusion criteria was people aged ≥60 years old. The exclusion criteria were older people who were illiterate and had neuromotor limitations in lower extremity.The data was collected by checking the visual acuity of the older people with Snellen chart. Falls Efficacy Scale International (FES-I) questionnaire was used to determine the risk of falling.

Results: Ninety-seven older people participated in this research.The results of bivariate analysis used Spearman correlation test showed that there was no correlation between the better eye visual acuity and the risk of falls in the older people (FES-I) (r = 0.190 and p = 0.063) and there was a significant correlation between the worse eye visual acuity and the risk of falls in the older people (r = 0.240 and p = 0.018).

Conclution: 1) There is no correlation between the better eye visual acuity and the risk of falls in the older people. 2) There is a correlation between the worse eye visual acuity and the risk of falls in the older people.

Keywords: Visual acuity, Risk of Falls, FES-I
Prediction of Drug Combinations with a Network Embedding Method
Authors: Wang Tianyun , Chen Lei , Zhao Xian 
Published: February 2019

Aim and Objective:
There are several diseases having a complicated mechanism. For such
complicated diseases, a single drug cannot treat them very well because these diseases always
involve several targets and single targeted drugs cannot modulate these targets simultaneously. Drug
combination is an effective way to treat such diseases. However, determination of effective drug
combinations is time- and cost-consuming via traditional methods. It is urgent to build quick and
cheap methods in this regard. Designing effective computational methods incorporating advanced
computational techniques to predict drug combinations is an alternative and feasible way.

Method:
In this study, we proposed a novel network embedding method, which can extract
topological features of each drug combination from a drug network that was constructed using
chemical-chemical interaction information retrieved from STITCH. These topological features were
combined with individual features of drug combination reported in one previous study. Several
advanced computational methods were employed to construct an effective prediction model, such as
synthetic minority oversampling technique (SMOTE) that was used to tackle imbalanced dataset,
minimum redundancy maximum relevance (mRMR) and incremental feature selection (IFS)
methods that were adopted to analyze features and extract optimal features for building an optimal
support machine vector (SVM) classifier.

Results and Conclusion:
The constructed optimal SVM classifier yielded an MCC of 0.806, which
is superior to the classifier only using individual features with or without SMOTE. The performance
of the classifier can be improved by combining the topological features and essential features of a
drug combination.
Antitumoral and Anticholinesterasic Activities of the Seven Species from Rubiaceae
Authors: Volobuff Carla R.F. , Junior Pedro C.O. , dos Santos Sidney M. , Pereira Zefa V. , Ferreira Diego C. , Cardoso Claudia A.L. , Ruiz Ana L.T.G. , Foglio Mary A. , de Carvalho João E. , Formagio Anelise S.N. 
Published: February 2019

Background:
The genus Psychotria and Palicourea are reported as a source of alkaloids and
iridoids, which exhibit biological activities. This study aimed to evaluate antiproliferative and anticholinesterase
activities and quantification of the alkaloids of seven species among the genus found in
Mato Grosso do Sul region in Brazil.

Methods:
Concentrations of alkaloids were measured spectrophotometrically. The extracts were submitted
to antiproliferative activity against ten cell lines. The anticholinesterase activity of the extracts
was developed using brain structures of male Wistar rats: cerebral cortex, hippocampus, hypothalamus
and striatum by the Ellman method.

Results:
Alkaloids from Psychotria and Palicourea species were quantified which showed values of
47.6 to 21.9 µg/g. Regarding the antiproliferative potential, Palicourea crocea demonstrated selectivity
against the 786-0 cell line (GI50: 22.87 µg/mL). Psychotria leiocarpa inhibited cell growth against
OVCAR-3 (GI50: 3.28 µg/mL), K-562 (GI50: 5.26 µg/mL), HaCaT (GI50: 27.20 µg/mL), PC-3 (GI50:
34.92 µg/mL), MCF-7 (GI50: 35.80 µg/mL) and P. capillacea showed activity against OVCAR-3 (GI50:
2.33 µg/ml) and U251 (GI50: 16.66 µg/ml). The effect of acetylcholinesterase inhibition was more effective
in the hippocampus, demonstrating inhibition for Paliourea crocea, Psychotria deflexa,
P. brachybotrya and P. leiocarpa of 70%, 57%, 50% and 40%, respectively, followed by
P. poeppigiana and P. capillacea, inhibiting 21%, compared to the control.

Conclusion:
Herein, the present work showed for the first time, anticholinesterasic and antiproliferative
activities of extracts of Palicourea and Psychotria seem to be mainly associated with the levels of
alkaloids in the leaves of these species.
Synthesis, Characterization, and Dynamic Behavior of Well-defined Dithiomaleimide-functionalized Maltodextrins
Authors: Hidalgo Francisco J. , Lorentz Nathan A.P. , Luu TinTin B. , Tran Jonathan D. , Wickremasinghe Praveen D. , Martini Olnita , Iovine Peter M. , Schellinger Joan G. 
Published: February 2019

:Maltodextrins have an increasing number of biomedical and industrial applications due to their attractive physicochemical properties such as biodegradability and biocompatibility. Herein, we describe the development of a synthetic pathway and characterization of thiol-responsive maltodextrin conjugates with dithiomaleimide linkages. 19F NMR studies were also conducted to demonstrate the exchange dynamics of the dithiomaleimide-functionalized sugar end groups.
Electrochemical Determination of Norepinephrine at Poly (p-aminobenzenesulfonic Acid) Modified Sensor
Authors: Yağcı Şevket Zişan , Savan Ebru Kuyumcu , Erdoğdu Gamze 
Published: February 2019

Objective:In this study, it was aimed to prepare an electrochemical sensor capable of assigning Norepinephrine in the presence of an interference such as ascorbic acid.Methods:A sensitive modified sensor was prepared by electrodeposition of p-aminobenzenesulfonic acid (p-ABSA) to the glassy carbon electrode by cyclic voltammetry. The electrooxidation of Norepinephrine was accomplished by cyclic and differential pulse voltammetry.Results:The current values were enhanced and the peak potentials of Norepinephrine and ascorbic acid were separated at the sensor compared to the bare electrode. There was linearity between the oxidation current and concentration of Norepinephrine ranging from 0.5 to 99.8 μM in phosphate buffer solution at pH 7.0. The limit of detection was 10.0 nM and the sensitivity was 0.455 μA/μM.Conclusion:The determination of Norepinephrine was successfully performed in real samples such as blood serum and urine at the poly (p-ABSA) sensor. To the best of our knowledge, this is the first study to detect Norepinephrine in the presence of ascorbic acid at poly (p-ABSA) modified sensor in the literature.
Drug/Vehicle Impacts and Formulation Centered Stratagems for Enhanced Transdermal Drug Permeation, Controlled Release and Safety: Unparalleled Past and Recent Innovations-An Overview
Authors: Manickam Balamurugan , Sreedharan Rajesh , Chidambaram Kumarappan 
Published: February 2019

:Transdermal drug delivery systems (TDDS) are one of the fascinating unconventional drug delivery systems offering plentiful advantages of which patient compliance is of paramount importance. However, as a matter of fact, the transdermal delivery of drug molecules is absolutely a tedious job which is precisely influenced by a number of factors including penetration barrier properties of the skin, drug characteristics formulation allied issues, etc. Over the years, innumerable tremendous efforts have been made in transporting the drugs through the skin into the systemic circulation by noteworthy tactics. This paper discusses such revolutionary formulation based techniques that have been endeavored in achieving the enhanced skin permeation of drugs, controlled release, and safety.
Cancer Therapy Based on Smart Drug Delivery with Advanced Nanoparticles
Authors: Kong Xiangqi , Liu Yi , Huang Xueyan , Huang Shuai , Gao Feng , Rong Pengfei , Zhang Shengwang , Zhang Kexiang , Zeng Wenbin 
Published: February 2019

Background:
Cancer, as one of the most dangerous disease, causes millions of deaths every year. The
main reason is the absence of an effective and thorough treatment. Drug delivery systems have significantly
reduced the side-effect of chemotherapy. Combined with nanotechnology, smart drug delivery systems including
many different nanoparticles can reduce the side-effect of chemotherapy better than traditional drug delivery
systems.

Methods:
In this article, we will describe in detail the different kinds of nanoparticles and their mechanisms
emphasizing the triggering factors in drug delivery. Besides, the application of smart drug delivery systems in
imaging will be introduced.

Results:
Combined with nanotechnology, smart drug delivery systems including many different nanoparticles
can reduce the side-effect of chemotherapy better than traditional drug delivery systems.

Conclusion:
Despite considerable progress in nanoparticle research over the past decade, such as smart drug
delivery systems for the treatment of cancer, molecular imaging probes and the like. The range of nanoparticles
used in multifunction systems for imaging and drug delivery continues to grow and we expect this dilatation to
continue. But to make nanoparticles truly a series of clinical products to complement and replace current tools,
constant exploration efforts and time are required. Overall, the future looks really bright.
Grape Seed Proanthocyanidins Protect N2a Cells against Ischemic Injury via Endoplasmic Reticulum Stress and Mitochondrial-associated Pathways
Authors: Fu Kun , Chen Liqiang , Miao Lifeng , Guo Yan , Zhang Wei , Bai Yunan 
Published: February 2019

Background/Objective:
Grape seed proanthocyanidins (GSPs) are a group of polyphenolic
bioflavonoids, which possess a variety of biological functions and pharmacological properties. We
studied the neuroprotective effects of GSP against oxygen-glucose deprivation/reoxygenation
(OGD/R) injury and the potential mechanisms in mouse neuroblastoma N2a cells.

Methods:
OGD/R was conducted in N2a cells. Cell viability was evaluated by CCK-8 and LDH release
assay. Apoptosis was assessed by TUNEL staining and flow cytometry. Protein levels of cleaved
caspase-3, Bax and Bcl-2 were detected by Western blotting. CHOP, GRP78 and caspase-12 mRNA
levels were assessed by real-time PCR. JC-1 dying was used to detect mitochondrial membrane potential.
ROS levels, activities of endogenous antioxidant enzymes and ATP production were examined to
evaluate mitochondrial function.

Results:
GSP increased cell viability after OGD/R injury in a dose-dependent manner. Furthermore,
GSP inhibited cell apoptosis, reduced the mRNA levels of CHOP, GRP78 and caspase-12 (ER stressassociated
genes), restored mitochondrial membrane potential and ATP generation, improved activities
of endogenous anti-oxidant ability (T-AOC, GXH-Px, and SOD), and decreased ROS level.

Conclusion:
Our findings suggest that GSP can protect N2a cells from OGD/R insult. The mechanism
of anti-apoptotic effects of GSP may involve attenuating ER stress and mitochondrial dysfunction.
GABA and 5-HT Receptor Mediated Anxiolytic Effect of Essential Oil of Ferula sumbul Hook. Roots
Authors: Batra Sonali , Kumar Ashwani , Sharma Anupam 
Published: February 2019

Background:Ferula sumbul Hook. (Umbelliferae) roots have been traditionally used as sedative in nervous disorders.Objective:The present study identifies the components of essential oil of F. sumbul roots (EOFS) using GC-MS analysis and further evaluates mechanism-based anxiolytic potential of oil.Materials and Methods:EOFS was extracted using Clevenger apparatus, and was screened for anxiolytic activity using an elevated plus maze model. A battery of models was subsequently used to confirm the anxiolytic potential of EOFS. Further, benzodiazepine (BZD) receptor antagonist flumazenil and pentylenetetrazole (PTZ) were used for investigating the possible involvement of GABA receptors.Results:GC-MS analysis of EOFS revealed the presence of 32 components comprising triterpenoids and their derivatives. The oil exhibited significant anxiolytic activity at 50 μl/kg in various models like the elevated plus maze, light/dark, mirror chamber, open-field and mCPP-induced anxiety. The observation that anxiolytic effect of EOFS was completely blocked by benzodiazepine (BZD) receptor antagonist flumazenil, and partially by pentylenetetrazole, clearly demonstrates that anxiolytic activity of the oil is mediated mainly through BZD site on GABA receptors. Further, a significant reversal of mCPP induced anxiety by EOFS strongly indicates the possible involvement of 5-HT receptors in mediating anxiolytic activity of the oil.Conclusion:Results of the present study clearly demonstrates the anxiolytic potential of EOFS and, thus, validates the traditional relevance of the plant. This is the first report not only on multi-model based antianxiety activity of EOFS but also on the possible antianxiety mechanism of the oil.