bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of genetic variations of five MMAF-related genes and their associations with litter size in goat
Authors: Wang Zhen , Pan Yun , He Libang , Chen Hong , Pan Chuanying , Qu Lei , Song Xiaoyue , Lan Xianyong 
Published: September 2019

Abstract
Background: Multiple morphological abnormalities of the sperm flagella (MMAF) makes an assignable contribution to male infertility, including QRICH2 , CFAP43 , CFAP44 , CFAP69 , CCDC39 , AKAP4 and DNAH1 gene. This work studied 28 putative indel mutations of MMAF related genes including QRICH2 , CFAP69 , CFAP43 , CCDC39 and DNAH1 gene and their correlation with the first-born litter sizes of 769 Shaanbei white cashmere (SBWC) goats.
Results: Electrophoresis and DNA sequencing analysis showed the 11-bp indel within QRICH2 ( QRICH2 -P4), the three indel variations in CFAP69 ( CFAP69 -P4, CFAP69 -P6 and CFAP69 -P7) and the 27-bp indel of DNAH1 ( DNAH1 -P1) were found to be polymorphic. The 27-bp indel variation within DNAH1 was not in consistent with HWE and the other four indel of QRICH2 and CFAP69 were in consistent with HWE. The linkage disequilibrium (LD) analysis showed the 8-bp indel ( CFAP69 -P4) and the 6-bp indel ( CFAP69- P6) within CFAP69 were in complete LD with each other (D'=0.99, r 2 =1.00). The 27-bp indel mutation within DNAH1 was strongly significantly associated with first-born litter sizes of SBWC goats ( P ＜0.01) and the average litter size of II genotype was significantly greater than ID and DD genotypes ( P = 0.003). In single-lamb and multi-lamb of goat groups, the genotype distributions of the 27-bp indel was significantly different ( P = 0.002). While the 11-bp indel variation of QRICH2 and three indel mutations (P4, P6 and P7) of CFAP69 identified were not ( P ＞0.05).
Conclusions: These findings suggest the 27-bp indels in the goat DNAH1 can be used as an effective molecular marker for marker-assisted selection of goats reproduction breeding in the future.
Responses of Long‐Term Cattle Manure on Soil Physical and Hydraulic Properties under a Corn–Soybean Rotation at Two Locations in Eastern South Dakota
Authors: Ozlu Ekrem , Kumar Sandeep , Arriaga Francisco J. 
Published: September 2019

Core Ideas
Manure improved soil hydrological properties in comparison with those of inorganic fertilizer and control.
Manure decreased soil bulk density but increased C stocks and water retention compared with inorganic fertilizer.
The higher rate of manure decreased soil bulk density and increased C stocks compared with lower rates of manure and inorganic fertilizer.
Manure can enhance soil organic carbon (SOC) and soil hydrological properties, such as soil water retention (SWR) and water infiltration (qs), which are crucial for crop production. The present study was conducted to investigate the impacts of different rates of manure (low, medium, and high) and inorganic fertilizer (INF) on soil bulk density (ρb), penetration resistance (SPRc), SWR, and qs at two long‐term experimental sites located in eastern South Dakota. The study sites were established under reduced‐till corn (Zea mays L.)–soybean [Glycine max (L.) Merr.] rotation. Dairy solid manure was used for the Brookings site, whereas beef solid manure was used for the Beresford site. On an average, manure application (1.02 Mg m−3) reduced the ρb by 19% compared with INF application (1.27 Mg m−3) at 0‐ to 10‐cm depth for the Brookings site and by 11% for the Beresford site (manure, 1.08 Mg m−3; fertilizer, 1.21 Mg m−3). Soil qs was significantly increased by 33 and 29% at the Brookings site and by 43 and 36% at the Beresford site under manure application compared with the INF and control. On average, SWR with manure application was higher compared with that of fertilizer at both depths for the Brookings and Beresford sites. Pearson correlation analysis showed that ρb and SPRc were negatively correlated and that SOC stock and qs were positively correlated with SWR and pore size distributions. This study showed that long‐term manure application can be beneficial in enhancing soil physical and hydraulic properties, which can enhance crop production.
STRATEGI KOMUNIKASI DAKWAH MASYARAKAT ATAS KONFLIK TANAH DI DESA SUROKONTO WETAN KECAMATAN PAGERUYUNG KABUPATEN KENDAL
Authors: Rachmawati Farida , Rokhmad Abu , Supena Ilyas 
Published: September 2019

<p><em>Land is an important source of life for farmers. Society’s effort maintain and obtain recognition for landoften lead to conflict. Include land conflict in Surokonto Wetan Village, Pageruyung District, Kendal Regency. This study aims to knowing history and conflict dynamics in Surokonto Wetan village, analyzing communication strategic that using by society to settlement of land conflict. The result showing that: firstly, land conflict in Surokonto Wetan is asyimmetric conflict between society and Perhutani. Secondly, communication strategic that using by society in Waisbord framework about problem definition, goal selection affecting strategic choosing, tactics and continuity movement relating with people’s motivation to better change. The basis of various actions is to free land to be owned by societys and free two detained societys, this goal underlies every manifestation of community action through demonstrations, negotiations, appeals until the goal is reached.</em></p><p align="center"> </p><p align="center">****</p><p>Tanah merupakan sumber kehidupanyang penting bagi masyarakat petani. Usaha mempertahankan dan memperoleh pengakuan atas tanah tak jarang menimbulkan konflik. Termasuk konflik tanah yang terjadi di Desa Surokonto Wetan Kecamatan Pageruyung Kabupaten Kendal. Penelitian ini bertujuan mengetahui bagaimana sejarah dan dinamika konflik tanah di Desa Surokonto Wetan, menganalisis strategi komunikasi yamg digunakan masyarakat untuk penyelesaian konflik. Hasil penelitian memperlihatkan, <em>pertama, </em>konflik tanah di Surokonto Wetan merupakan jenis konflik asimetris yang melibatkan masyarakat dengan Perum Perhutani.<em>Kedua, </em>Strategi komunikasi yang digunakan masyarakat dalam kerangka Waisbord terkait definisi permasalahan, tujuan yang ingin dicapai yang mempengaruhi pemilihan strategi, taktik dan kontinuitas gerakan terkait motivasi orang terhadap perubahan yang lebih baik. Dasar berbagai aksi adalah untuk membebaskan tanah agar dimiliki warga dan membebaskan dua warga yang ditahan, tujuan ini mendasari setiap aksi masyarakat yang terwujud melalui demonstrasi, negosiasi, kasasi yang dilakukan hingga tercapai tujuan.</p>
A rapid and efficient removal approach for degradation of metformin in pharmaceutical wastewater using electro-Fenton process; optimization by response surface methodology
Authors: Dolatabadi Maryam , Ahmadzadeh Saeid 
Published: September 2019

Abstract
Presence of emerging contaminants such as pharmaceutical products in aquatic environments has received high concern due to their undesirable effect on wildlife and human health. Current work deals with developing a treatment model based on the electro- Fenton (EF) process for efficient removal of metformin (MET) from an aqueous medium. The obtained experimental results revealed that over the reaction time of 10 min and solution pH of 3, the maximum removal efficiency of 98.57% is achieved where the value of MET initial concentration, current density, and H2O2 dosage is set at 10 mg.L−1, 6 mA.cm−2, and 250 μL.L−1, respectively, which is in satisfactory agreement with the predicted removal efficiency of 98.6% with the desirability of 0.99. The presence of radical scavengers throughout the mineralization of MET under the EF process revealed that the generation of •OH radicals, as the main oxidative species, controlled the degradation mechanism. The obtained kinetics data best fitted to the first order kinetic model with the rate constant of 0.4224 min−1 (R2 = 0.9940). The developed treatment process under response surface methodology (RSM) was employed for modeling the obtained experimental data and successfully applied for efficient removal of the MET contaminant from pharmaceutical wastewater as an adequate and cost-effective approach.
Study of the adsorption and photocatalytic properties of copper oxide with different morphologies in removal of Cr(III) ion from aqueous media
Authors: Kondabey Jamileh , Ghorbani Mohammad Hossein , Aghaie Hossien , Fazaeli Reza 
Published: September 2019

Abstract
Chromium Cr(III) is considered as a toxic pollutant in industrial wastewater. Photocatalytic processes can be used as an efficient method for the treatment of heavy metal wastewaters. This study was conducted to synthesize copper (II) oxide (CuO) with dendrite, leaf and feather morphologies. Synthesized CuO with dendrite and leaf morphologies were characterized by XRD, SEM, and BET/BJH and CuO with feather morphology by XRD, SEM, BET/BJH, FTIR, TEM and DRS techniques. Parameters such as morphology CuO, the contact time (h), and adsorbent dosage (g) in adsorption of Cr(III) and morphology CuO, pH and initial concentration of Cr(III) in the photocatalytic oxidation were investigated. The results demonstrate that CuO feather at 24 h contact time with 0.1 g adsorbent with an adsorption efficiency of 57.24% has the highest efficiency compared to CuO of dendrite and leaf. Oxidation results demonstrate that CuO feather at 2 h with 0.1 g adsorbent dosage and pH = 7 had 89.14% removal efficiency. Also, oxidation results demonstrate that CuO feather at 2 h with 0.1 g adsorbent dosage and pH = 8 had 99.99% removal efficiency, which indicates the high efficiency of the feather.
Prognostic Value of Cardiac Biomarkers Assessment in Combination with Myocardial 2D Strain Echocardiography for Early Detection of Anthracycline-Related Cardiac Toxicity
Authors: Mahjoob Mohammad P. , Sheikholeslami Seyed A. , Dadras Morvarid , Mansouri Hamdollah , Haghi Mahshid , Naderian Mohammadreza , Sadeghi Leila , Tabary Mohammadreza , Khaheshi Isa 
Published: September 2019

Background:
Anthracyclines, a widely used chemotherapy agent with a definite survival
improvement, can result in cardiac toxicity presenting with HF (heart failure).

Objective:
We aim to assess the predictive value of cardiac biomarkers assessment in combination
with myocardial two-dimensional strain echocardiography for early detection of cardiac toxicity in
patients who underwent Anthracycline-based chemotherapy.

Method:
Fifty-two consecutive adult patients scheduled to undergo the first course of
Anthracycline-based chemotherapy were subjected to the study. All the patients underwent highly
sensitive 2D echocardiographic evaluation before the treatment, 4 and 12 weeks after completion of
first-course chemotherapy. Longitudinal and segmental strains were measured. Serum levels of
High-sensitive cardiac troponin I (hscTn-I) and N-terminal-pro-BNP (NT-proBNP) were also
assessed before the initiation and 3 weeks after completion of first-course chemotherapy.

Result:
Fifteen patients (28.8%) revealed a decrease in LVEF (Left Ventricular Ejection Fraction)
throughout the evaluations, while just 5 patients met the criteria of cardiac toxicity (9.6%). AUC for
Global Longitudinal Strain (GLS) ROC curve at 4 weeks of follow-up was calculated to be 0.968.
Inferoseptal Systolic Longitudinal Strain (SLS) had the highest AUC value (AUC: 0.934) among
different wall SLS. LVESD (Left Ventricular End-Systolic Diameter) at first and second evaluation
could predict the risk of cardiac toxicity among LVESD, LVEDD (Left Ventricular End Diastolic
Diameter) and LVEDV (Left Ventricular End-Diastolic Volume). Among cardiac biomarkers, hscTnI
had higher sensitivity, while NT-proBNP had higher specificity for cardiac toxicity.

Conclusion:
This study has shown that hs-cTnI with good sensitivity can predict cardiac toxicity in
Anthracycline-based chemotherapy receiver. The use of strain with speckle echocardiography
method has a prognostic value; however, both longitudinal and segmental strain should be assessed.
Lateral and inferoseptal SLS (Segmental Longitudinal Strain) are specific markers of cardiac
toxicity in the course of anthracycline-related cardiac toxicity.
Variable Gain for Iterative Learning Control
Authors: Su Jianhuan , Zhang Yinjun , Chen Mengji 
Published: September 2019

Background:
At present, the gain of most ILC algorithms is fixed, and the convergence
speed of the system depends on the learning law, which will lead to the complexity of the structure
of the learning law, and variable gain can accelerate the convergence speed without changing the
structure of the learning law as variable gains are introduced into ILC.

Objective:
In this paper, the D-type learning law is used. Firstly, the variable gain iterative learning
controller is designed. Secondly, the convergence of the learning law is analyzed.

Methods:
Finally, in order to illustrate the effectiveness of this method, the simulation is carried out
using MATLAB.

Results and Conclusion:
The simulation results show that the variable gain iterative learning control
can improve the convergence speed of the iteration, and weaken the restrictions on the initial input.
ONCE DAILY IMMEDIATE-AND EXTENDED-RELEASE BILAYER TABLETS OF ETORICOXIB: A STUDY ON THE RELEASE KINETICS
Authors: MISHRA BIBASWAN , MOHANTY BISWARANJAN 
Published: September 2019

Objective: In the present work, the main objective was to develop bilayer extended release matrix tablets of etoricoxib by providing a loading dose followed by maintenance dose that expected to improve the therapeutic efficacy of the medication with less toxic effect.
Methods: Bilayer tablets of etoricoxib was developed successfully with the meticulous proportion of release controlling Hydroxy propyl methyl cellulose K100 (HPMC K100) and lactose. The tablets were prepared by wet granulation technique. Granules for immediate layer and extended layer for different formulations were prepared separately. The formulations were developed and evaluations were performed to examine the parameters that affect the in vitro performance of the tablets. The drug-excipient compatibility was ensured by Fourier transform infrared spectroscopy (FTIR) study.
Results: The values of physical parameters of all formulations were found within appreciable limit. Formulation containing HPMC K 100 and lactose in the proportion of 2:1 in the extended release layer was able to release 26.22% of drug in 15 min and shown a steady release of drug for an extended period of 12 h. The dissolution data was put in Korsemeyer–Peppas model in order to find out n value, which describes the drug release mechanism. The n-value of different formulations were found to be variable. The Fourier transform infrared spectroscopy (FTIR) study revealed absence of any other new peaks and also no differences in the positions of the absorption bands in the bilayer tablet F8 that indicate the lack of significant interactions between etoricoxib and other excipients.
Conclusion: It had been concluded that once daily immediate-and extended release bilayer tablet of etoricoxib can be formulated with profound physical characteristics and dissolution properties. This resulted in reducing the daily dose and thus minimise the cardiovascular toxicity of etoricoxib.
ACUTE TOXICOLOGICAL INVESTIGATION OF POLYETHYLENE GLYCOL DERIVATIZED FOURTH AND FIFTH GENERATION POLY (PROPYLENEIMINE) DENDRIMERS
Authors: DWIVEDI NITIN , PARMAR DUSHYANT KUMAR , KESHARWANI PRASHANT , SHAH JIGNA 
Published: September 2019

Objective: The aim of the present study leads a comparative assessment of the toxicological profile of PEGylated fourth and fifth-generation poly (propylene imine) dendrimers (PPI).
Methods: 4.0G and 5.0G generations of PPI dendrimer were synthesized and PEGylated with Mono polyethylene glycol 5000 (MPEG-5000). Each PEGylated 4.0G and 5.0G dendrimeric generation were administered in three different doses: 2.5 mg/kg, 25 mg/kg and 250 mg/kg (i.e., low, intermediate and high dose) to wister rats. After the dose administration, the blood and tissue samples of wister rats were collected after 24 h and 15 d after. All the collected samples were proceeded for hematological, biochemical and histopathological studies.
Results: After 24 h of (250 mg/kg) dose administration PEGylated 5.0G PPI dendrimer the RBC count, hemoglobin content and WBC count were found 7.873±0.129 mill/cmm, 13.833±0.491g/dl and 9033.33±2384.906 mill/cmm, while PEGylated 4.0G PPI dendrimer indicated RBC count, hemoglobin content and WBC count 8.733±0.239 mill/cmm, 14.033±0.12 g/dl and 9666.667±2567.316 mill/cmm, in blood samples as compare to RBC count 9.346±0.037 mill/cmm, hemoglobin content 15.35±0.15 g/dl and WBC count 8500±286.675 mill/cmm of the animals of normal control group. Thus there are no remarkable changes (p>0.05) in RBC count, hemoglobin content and other hematological profile after 24 h in comparison of normal control group of animals. Similarily insignificant changes (p>0.05) in serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), lactate dehydrogenase (LDH) and sections of different organs indicate inoffensive nature of both generations of PEGylated 4.0G and 5.0 G PPI dendrimers.
Conclusion: It can be concluded that fifth-generation PPI dendrimers are more suitable as compared to fourth generation of PPI dendrimer, while both dendrimers are not generating any severe toxicity.
SODIUM ALGINATE/GELATIN MICROBEADS-INTERCALATED WITH KAOLIN NANOCLAY FOR EMERGING DRUG DELIVERY IN WILSON’S DISEASE
Authors: REDDY O. SREEKANTH , SUBHA M. C. S. , JITHENDRA T. , MADHAVI C. , RAO K. CHOWDOJI , MALLIKARJUNA B. 
Published: September 2019

Objective: The aim of the present study was to fabricate and evaluate the drug release studies using Sodium Alginate (SA) and Gelatin (GE) microbeads intercalated with Kaolin (KA) nanoclay for sustained release of D-Penicillamine (D-PA).
Methods: Sodium alginate/gelatin/Kaolin blend microbeads were prepared by an extrusion method by using glutaraldehyde (GA) as a crosslinker. The obtained microbeads were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and X–ray diffraction (XRD). Drug release kinetics of the microbeads was investigated in simulated intestinal fluid (pH 7.4) at 37 °C.
Results: Microbeads formation was confirmed by FTIR spectroscopy. X-RD reveals that the KA should be intercalated with the drug and also it confirms the molecular level dispersion of D-Penicillamine into microbeads. Scanning Electron Microscopy (SEM) studies reveal that the beads were in spherical shape with some wrinkled depressions on the surface. The in vitro release study indicates the D-Penicillamine released in a controlled manner. The in vitro release kinetics was assessed by Korsmeyer-Peppas equation and the ‘n’ value lies in between 0.557-0.693 indicates Non-Fickian diffusion process.
Conclusion: The results suggest that the developed KA intercalated microbeads are good potential drug carrier for the controlled release of D-PA.
ANALYSIS OF PALM OIL AS OIL ADULTERANT IN OLIVE AND PUMPKIN SEED OILS IN TERNARY MIXTURE SYSTEMS USING FTIR SPECTROSCOPY AND CHEMOMETRICS
Authors: IRNAWATI  , S. RIYANTO , S. MARTONO , A. ROHMAN 
Published: September 2019

Objective: The study was designed to develop Fourier transform infrared (FTIR) spectroscopy in conjunction with chemometrics techniques of multivariate calibration and discriminant analysis (DA) for analysis of palm oil in a ternary mixture with EVOO and PSO.
Methods: FTIR spectra of pure palm oil (PO), extra virgin olive oil (EVOO), pumpkin seed oil (PSO) and its ternary mixtures randomly prepared were scanned using FTIR spectrophotometer at wavenumbers of 4000-650 cm-1 corresponding to mid-infrared region, with resolution of 8 cm-1 and 32 scanning using sampling technique of attenuated total reflectance (ATR). Two calibrations in multivariate models, namely principle component (PCR) and partial least square (PLS) regressions were used to facilitate quantification of PO.
Results: The PLS using first derivative FTIR–ATR spectra at 3100-2750 combined with 1500-663 cm-1 showed the best prediction models for quantification of PO in ternary mixtures with EVOO and PSO. Using this condition, correlation coefficient (R) values for the relationship between actual values and FTIR predicted values of 0.9967 and 0.9906 were achieved in calibration and validation models, respectively. The errors in calibration and prediction models, expressed by RMSEC and RMSEP, were low, i.e. 0.0080% and 0.0152%, respectively. DA using absorbance values at the same wavenumbers also offered the optimum discrimination model for discrimination between PO and PO mixed with EVOO and PSO in ternary mixtures.
Conclusion: This result concluded that FTIR spectra in conjunction with DA (for classification) and PLS (for quantification) is fast and accurate tools during the analysis of PO as oil adulterant in EVOO and PSO.
CHARACTERIZATION OF PHARMACOKINETICS OF 2-((3-(CHLOROMETHYL)BENZOYL)OXY) BENZOIC ACID IN RATS BY USING HPLC-DAD METHOD
Authors: Caroline  , Sie Nathania , Foe Kuncoro , Esar Senny Yesery , Jessica Maria Anabella 
Published: September 2019

Objective: A new compound of salicylic acid derivative, namely 2-((3-(chloromethyl)benzoyl)oxy)benzoic acid (3CBB), was synthesized to find a compound exhibiting higher analgesic activity and smaller ulcer irritation than acetylsalicylic acid (ASA). Therefore, this study aimed to investigate the pharmacokinetics of this new compound in rats, following a single dose oral administration of 3CBB (45 mg/kg BW).
Methods: Plasma samples of 9 healthy rats were collected before and up to 3 h after its oral administration, following an 18 h fasting period. Plasma concentrations of 3CBB were determined using a validated HPLC-DAD assay. Pharmacokinetic parameters were determined using the compartment model technique. All experiments were carried out in triplicate.
Results: The pharmacokinetic parameters of 3CBB obtained were as follows: Tmax= 28.9±1.1 min, Cmax = 0.57±0.02 µg/ml, AUCtotal = 66.3±1.0 µg min/ml, Kel = 0.018±0.002 min-1, and T1/2el = 39.4±3.9 min. The long elimination half-life and low Cmax indicated that 3CBB was extensively distributed in the deep and very deep tissues. This confirmed the unique and special characteristics of a highly lipophilic compound like 3CBB (log P = 3.73).
Conclusion: 3CBB demonstrated a slower onset of action and longer elimination time from the body compared to ASA. Thus this new compound is a potential candidate to be developed as a new drug.