bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obstructive sleep apnoea and lung function, and their association with nocturnal hypoxemia: results from the Swedish CArdioPulmonary bioimage Study (SCAPIS) – a cross-sectional study
Authors: Delshad Baz , Ljunggren Mirjam , Zhou Xing Wu , Theorell-Haglöw J , Janson Christer , Zou Ding , Hedner Jan , Grote Ludger , Blomberg Anders , Franklin Karl , Sahlin Carlin , Malinovschi Andrei , Lindberg Eva 
Published: November 2024

Obstructive sleep apnoea (OSA) and its associations with lung function.BackgroundOSA is highly prevalent and characterised by abnormal respiration during sleep. This large, population-based study aimed to investigate the associations between OSA and lung function in subjects aged 50–64 years.MethodThe population-based Swedish CArdioPulmonary bioimage Study includes information on anthropometry, comorbidities and spirometry. The current analysis included data from three centres (Gothenburg, Umeå and Uppsala) on whole-night respiratory polygraphy as a meta-analysis examining the overall effect size of lung function on sleep apnoea severity, expressed as ß-coefficient after stratifying for sex and adjusting for age, waist circumference and smoking status.ResultsData from9016participants (54%women, age58±4 years, body mass index27±4 kg/m2) with sleep recordings of good quality were included in the final analysis. Forced expiratory volume during1 s(FEV1) (ß=−0.10 (95% CI −0.16 to −0.03)),forced vital capacity(FVC) (−0.15 (−0.21 to −0.10)) anddiffusion capacity for carbon monoxide(DLCO) (−0.08 (−0.10 to −0.05)) were all negatively associated with theoxygen desaturation index(ODI) and also with per cent of registration with nocturnal oxygen saturation<90% FVC(−0.44 (−0.87 to −0.01)), FEV1(−0.86 (−1.36 to −0.36)) and DLCO(−0.47 (−0.60 to −0.35)). Additionally, a positive association was observed between FEV1(0.13 (0.05 to 0.22)) and DLCO(0.07 (0.04 to 0.09)) with the mean nocturnal saturation. There was a negative association between DLCOandapnoea-hypopnoea index, AHI, (ß=−0.04 (95% CI−0.06 to −0.03)), while no associations were found between FEV1or FVC and AHI.ConclusionIn OSA, lower lung function is more distinctly associated with the nocturnal hypoxic burden than AHI. Potential lung function impairment should be investigated in OSA patients with a high ODI relative to AHI.
Health-related quality of life in adults with metabolic syndrome: a multi-level analysis of family and individual level variation
Authors: Niknam Mahdieh , Olazadeh Keyvan , Azami Mobin , Boroumandieh Saeedeh , Yari-Boroujeni Reza , Izadi Neda , Azizi Fereidoun , Amiri Parisa 
Published: November 2024

Purpose
The current study aimed to investigate the associations between metabolic syndrome (MetS) with health-related quality of life (HRQoL) using multilevel analysis among the Iranian adult population.

Methods
This cross-sectional study was conducted in the framework of the Tehran Lipid and Glucose Study (TLGS). Participants were 6113 participants (3318 women and 2795 men) aged≥20 years of the TLGS seventh phase who had completed data on HRQoL and MetS. HRQoL was assessed using the short-form 12-item health survey V.2 and MetS defined based on the guidelines outlined in the Joint Interim Statement. The two-level model was fitted to assess the association between MetS and HRQoL.

Results
The prevalence of MetS and its components was higher in men, and regardless of metabolic status, men exhibited higher HRQoL values. The deleterious impact of MetS on HRQoL was more pronounced in women, while the detrimental effects of MetS on men’s HRQoL were confined to specific subscales. These results were obtained through multilevel analysis, considering both familial and individual variation levels. Moreover, our investigation highlighted the positive influence of leisure-time physical activity on both the physical and mental component summaries (PCS and MCS, respectively), regardless of gender. Education had a greater positive impact on PCS in both sexes. Additionally, a history of cardiovascular diseases was associated with a decline in mental and physical HRQoL, while age was linked to a decline in PCS and MCS, and smoking was associated with a decline in MCS.

Conclusion
This study revealed the significant influence of gender, as well as the unique characteristics and circumstances of individuals, on the relationship between MetS and HRQoL in a general population with low/middle income.
Association between life satisfaction and health behaviours among older adults: a systematic review and meta-analysis protocol
Authors: Alumona Chiedozie James , Scott David R , Odole Adesola C , Nweke Martins , Kalu Michael , Awosoga Oluwaghohunmi Adetunji 
Published: November 2024

IntroductionLife satisfaction is a key indicator of successful ageing and reflects well-being. There is evidence of the association between life satisfaction and health behaviours among older adults. Therefore, this systematic review and meta-analysis protocol seeks to determine the strength and direction of the association between life satisfaction and health behaviours among older adults.Methods and analysisThis protocol followed the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines. We will search the electronic databases (MEDLINE, APA PsycINFO, Web of Science, CINAHL and Global Health) from inception to date. Only observational studies that described the association between life satisfaction and health behaviours—smoking, alcohol drinking, physical activity, diet/nutrition and sleep—will be included. Two independent reviewers will conduct screening, data extraction and risk of bias assessment of the articles. The risk of bias will be assessed using the Joanna Briggs Institute critical appraisal tools for cohort and analytical cross-sectional studies. Studies will be included in the meta-analysis if they report zero-order associations between life satisfaction and health behaviours; otherwise, a narrative synthesis will be presented.Ethics and disseminationThis study does not require ethics approval, as it involves analysing secondary data from published studies. The completed review will be published in a peer-reviewed journal and presented at conferences.Trial registration numberPROSPERO (CRD42023441386).
Surveillance of carbapenem resistance in Asian countries: a systematic review and meta-analysis
Authors: Jayathilaka Nishadi , Denagamagei Sashini Shehana , Nakkawita Dilini , Senaratne Thamarasi Nirmali 
Published: November 2024

IntroductionCarbapenems are used to treat multidrug-resistant organisms as last-resort antibiotics. Resistance to carbapenems is an emerging public health threat worldwide, with alarming reported rates in Asian countries. To minimise further spread of resistant strains and guide interventions, it is important to understand the prevalence rates and causative molecular determinants. Therefore, the systematic review and meta-analysis arising from this protocol will aim to comprehensively describe the available surveillance data on carbapenem resistance in Asian countries to provide an in-depth overview of the carbapenem resistance status in this region.Methodology and analysisA systematic review and meta-analysis will be conducted via PubMed, ScienceDirect, Cochrane Library and Web of Science databases. Additional articles and grey literature will be searched in Google Scholar, OpenGrey and Google Chrome by manually searching the reference lists of selected studies. The review question was designed according to components in the ECLIPSE (E-expectations, C-client, L-location, I-impact, P-profile and S-service) framework. Studies conducted with samples other than clinical samples will be excluded. Only original articles published in the English language will be included. The Joanna Briggs Institute critical appraisal tool will be used to assess the quality of the included studies. A random-effects meta-analysis will be performed if the data are sufficiently homogenous. Heterogeneity between studies will be assessed via the I² statistic. The subgroup analysis will be performed considering the type of sample, pathogen type, region/country where the studies were conducted and genetic determinants.Ethics and disseminationAs this study is conducted on the basis of published data, ethical approval is exempt. The findings of this study will be disseminated in a peer-reviewed journal with the intention of providing summarised data on the globally emerging threat of carbapenem resistance and emphasising the need to introduce alternative, more effective treatment options.PROSPERO registration numberCRD42024515806.
Exploring influential components and indicators in hospital resilience assessment: a scoping review protocol
Authors: Barzanji Arvin , Farrokhi Mehrdad , Ebadi Abbas , Saatchi Mohammad , Ahmadi Shokoufeh , Khankeh Hamidreza 
Published: November 2024

IntroductionHospitals are vital infrastructures that provide health services during emergencies and disasters. However, in recent years, disasters have led to hospital losses and interruptions in medical services. Consequently, the concept of resilience has garnered significant attention. Despite extensive research, the lack of clarity in explaining hospital resilience poses challenges in effective assessment and identifying key priorities for enhancing disaster risk management. Recently, the WHO’s Eastern Mediterranean Regional Office (EMRO) introduced a conceptual framework for the conceptualisation of hospital resilience, defining it through six interconnected components and four resilience capacities. Identifying specific indicators and characteristics for hospital resilience components based on the EMRO framework. This protocol outlines the method for conducting a scoping review to identify such indicators and characteristics to develop a comprehensive hospital resilience assessment tool.Methods and analysisThis scoping review will adhere to the six-step protocol proposed by Arksey and O’Malley. It aims to comprehensively understand current knowledge about resilient hospital characteristics and identify effective components and indicators for assessing hospital resilience. The review will encompass available articles indexed in PubMed, Scopus and Web of Science. Additionally, searches will explore the grey literature on Google Scholar, the WHO’s website and regional offices. There will be no publication date restrictions applied to the search. Quantitative and qualitative content analyses will assess and categorise the study results. Our protocol was drafted using the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols extension for scoping reviews.Ethics and disseminationThis protocol describes a scoping review within a doctoral thesis focused on health in emergencies and disasters, specifically hospital resilience. The study, associated with ethics code number (IR.USWR.REC.1402.120), aims to develop a comprehensive assessment tool for hospital resilience. Once peer-reviewed and published, the findings will inform experts, policymakers and relevant organisations in emergency and disaster management.
Exploring patient involvement in obstetrics and gynaecology education for medical students: a scoping review protocol
Authors: Kennedy Clare , Al-Tikriti Shahad , Abubakr Karima Ali , O'Higgins Amy C , McNulty Jonathan P , Cooney Naomi , Donnelly Suzanne , Higgins Mary 
Published: November 2024

IntroductionIt is important to incorporate the patient perspective into healthcare education, as we know that patients are experts in their own conditions. The expertise gained through lived experience serves to complement the theoretical knowledge that healthcare educators can provide. This scoping review aims to explore patient involvement in medical education within obstetrics and gynaecology, a specialty that can provide unique challenges and complexities to patient involvement due to its potentially highly sensitive and intimate nature. The goal of this study is to map the available literature on this topic which will allow for the identification of potential gaps in the provision of training for medical students in this field. The research also aims to highlight challenges that may be associated with patient involvement in this specialty in order to guide future initiatives.Methods and analysisThe Joanna Briggs Institute scoping review framework and methodology will be used to guide and conduct this scoping review. A systematic search of electronic databases MEDLINE, CINAHL, Embase, Scopus, PsycINFO, ERIC, Google Scholar, Web of Science, African Journals Online, Cochrane Library and SciVerse will be carried out. Articles will be limited to the English language. No geographical limitations will be placed on the search. Literature from 1960 to 2023 will be considered for inclusion which corresponds with the first reports of patient educators used to assist with the demonstration of clinical skills in obstetrics and gynaecology. Relevant academic journals will be hand-searched for the previous 5 years. Identified studies will be screened by two independent reviewers and data extraction carried out by the primary researcher. Key findings will be presented in tables and summarised in narrative form. Findings from the review will be reported according to the PRISMA Extension for Scoping Reviews reporting checklist.Ethics and disseminationEthical approval is not required for this study. The findings from the study will be submitted for publication in peer-reviewed journals and at medical education conferences.
Optimal timing of recombinant herpes zoster virus vaccination for a JAK inhibitor treatment in rheumatoid arthritis: a multicentre, open-label, randomised comparative study (STOP-HZ study): study protocol
Authors: Takanashi Satoshi , Ohmura Koichiro , Misaki Kenta , Ihata Atsushi , Matsui Toshihiro , Tohma Shigeto , Saegusa Jun , Sato Shinji , Matsubara Tsukasa , Yamaoka Kunihiro , Amano Koichi , Miyamoto Toshiaki , Mori Yasuko , Kaneko Yuko 
Published: November 2024

IntroductionJanus kinase (JAK) inhibitors are an important therapeutic option in the treatment of rheumatoid arthritis, but increase the risk of developing herpes zoster. Although a dry recombinant zoster vaccine (RZV) that can be used under immunosuppressive conditions has recently been developed, its optimal use and appropriate timing in patients scheduled to start JAK inhibitors is still unclear. The present study is designed to clarify the appropriate timing of JAK inhibitor initiation to measure varicella zoster virus (VZV)-specific IgG titers and VZV-specific T cell response in patients with rheumatoid arthritis who start tofacitinib at the first RZV vaccination or at the second one.Methods and analysisSTOP HZ (Effectiveness andSafeTyOfProphylactic RecombinantHerpesZoster Virus Vaccination for Rheumatoid Arthritis Patients with Tofacitinib Treatment) study is a multicentre, open-label, randomised, comparative study in patients with rheumatoid arthritis who are scheduled to start tofacitinib. This study enrols 60 study subjects in 12 sites. Enrolled subjects receive RZV two times on day 1 and week 8 and initiate tofacitinib 5 mg two times a day at the time of their first RZV (day 1, group A) or second RZV (week 8, group B) based on randomisation. The random assignment is performed centrally in a 1:1 ratio. Patients in Group B continue the same treatment until the start of tofacitinib treatment. Primary endpoint is VZV-specific IgG antibody titers at week 12 compared with those at baseline in each group. Secondary endpoints include comparison of VZV-specific IgG antibody between the groups, changes in disease activity of rheumatoid arthritis, VZV-specific T cell response and adverse events.Ethics and disseminationThe study has been approved by the Certified Review Board of Keio (No. 2022008), and conforms to the Declaration of Helsinki and good clinical practice guidelines. Written informed consent is obtained from participants prior to enrolment. The results of this study are planned to be submitted for publishment in relevant peer-review journals.Trial registration numberjRCTs031230329.
Mental healthcare in paediatric epilepsy clinics: implementation by non-mental health professionals
Authors: Coughtrey Anna E , Bennett Sophie , Stanick Cameo , Chorpita Bruce , Dalrymple Emma , Fonagy Peter , Cross J Helen , Ford Tamsin , Heyman Isobel , Moss-Morris Rona , Jetha Poonam , Myles-Hooton Pamela , Shafran Roz 
Published: November 2024

ObjectivesResearch has shown that children with epilepsy often experience mental health disorders but face barriers to effective care. One solution is to train healthcare professionals within paediatric epilepsy services to deliver psychological interventions. The aim of this paper was to examine aspects of treatment integrity of the ‘Mental Health Interventions for Children with Epilepsy’ (MICE) treatment, a modular cognitive behavioural therapy intervention for anxiety, depression and behavioural difficulties in childhood epilepsy.MethodsThe MICE treatment was delivered in paediatric epilepsy clinics by 21 healthcare professionals with limited mental health experience, supported by a comprehensive training and supervision package. Data from 2269 treatment sessions with 166 young people were analysed to examine adherence to the MICE protocol. Audio recordings from a randomly selected sample of 251 sessions were rated for therapist competence, of which 30 were independently rated by a second expert.ResultsTherapists administered the MICE intervention with integrity and closely adhered to the established protocol. Any adaptations made were related to the sequence of delivery rather than changes to the content.ConclusionsThe overall findings indicate that professionals in paediatric epilepsy clinics can be effectively trained and supported to administer evidence-based mental health interventions. Additional research is required to explore the link between integrity and clinical outcomes, as well as to determine the most effective methods for training and supervision. This is crucial for ensuring the successful implementation of mental health interventions for children with epilepsy and concurrent mental health needs.
Application of disposable digital hysteroscope for outpatient hysteroscopy in women undergoing artificial assisted reproductive procedures: a clinical research
Authors: Jiang Die , Dan Ling , Pasic Resad , Shervin Adel , Song Jianming , Feng Limin 
Published: November 2024

BackgroundHysteroscopy is the preferred method for the diagnosis and treatment of uterine diseases. With the increasing demand for outpatient hysteroscopy, disposable digital hysteroscopy has emerged, which can meet the requirements of diagnosis and treatment integration, and greatly reduce the labour and storage costs.MethodsA total of 108 outpatients who underwent hysteroscopy using disposable digital hysteroscope were divided into two groups: the non-porous group (group A, n=49) and the married with child group (group B, n=59). The patients’ general information and clinical data were recorded and statistical analysis was performed.ResultsNo differences were found between the age, weight, body mass index, menopausal status and indication for hysteroscopy of the two groups. The most common indication was embryo transfer failure. The surgical success rate of 108 patients was 100%, the concordance rate between hysteroscopic diagnosis of chronic endometritis and pathological diagnosis was 94.44% (68/72), while the false positive rate stood at 38.89% (14/36). Additionally, incidental findings rate for endometrial polyps was 92.00% (23/25) with a low false positive rate of only 6% (5/83). The mean visual analogue scale score of group A was 2.285±0.180, which was not significantly different from group B (p=0.483, 95% CI(−0.60-0.44)). The pregnancy rate among patients who received assisted reproductive technology and were followed up for 1 year after surgery was 66.67% (40/60), while the abortion rate stood at 5.00% (3/60).ConclusionsThe disposable digital hysteroscope is a valuable and effective tool for outpatient hysteroscopy.
Increased use of mud bottom by juvenile American lobsters (Homarus americanus) in Maces Bay and Seal Cove, Bay of Fundy, after three decades of population increases and predator declines
Authors: Dinning Kristin Midori , Lawton Peter , Rochette Rémy 
Published: November 2024

In the Bay of Fundy, American lobster ( Homarus americanus) abundance has soared since the early 1990s, and predators have declined, either of which could have caused juvenile lobster populations in preferred hard-bottom habitat to expand onto less-protective mud bottom. To investigate whether juvenile lobsters have increased use of mud bottom, we used scuba surveys (1989–2021) in Maces Bay and Seal Cove, in the Bay of Fundy. Whereas the 1990s surveys found no juveniles on mud at either site (though they were present on hard bottom), in subsequent decades, juveniles inhabited mud burrows at densities of 0.00039 m–2 to 0.0081 m–2. In Maces Bay, mud occupancy occurred after juvenile density increases on hard bottom, but evidence was mixed as to whether increased competition within hard-bottom habitat drove this change. Concurrent cod, haddock, hake, and wolffish declines suggest reduced predation also increased occupancy and survival on mud. Although it supports low juvenile densities, mud habitat may contribute to recruitment given its prevalence, particularly as warming seas allow lobster recruitment into cooler, deeper water over mud bottom.
Augmentation significative des superficies recouvertes par du paillis de plastique au saguenay–Lac-Saint-Jean, Québec, Canada
Authors: Paré Maxime C. , Morissette Olivier , Boivin Maxime , Piochon Marianne , Pichette André 
Published: November 2024

La production du maïs à ensilage dans la région du Saguenay–Lac-Saint-Jean (SLSJ) est limitée en raison du faible nombre d'unités thermiques maïs (UTM). Pour pallier cette contrainte, plusieurs producteurs utilisent un film de plastique translucide dit « oxo-biodégradable », permettant ainsi de devancer la date de semis et de bénéficier d'hybrides plus élevés en UTM. Toutefois, l'utilisation de ce type de plastique pourrait causer des problèmes importants en s'accumulant notamment dans les sols, les sédiments, les eaux et les organismes vivants. À ce jour, il demeure toutefois difficile de connaître les superficies recouvertes par ce plastique au fil des années. Nous avons entrepris une première étude pour connaître l’étendue de l'utilisation de cette pratique depuis 2018 dans la région à l'aide d'images satellitaires. Nos résultats indiquent que les superficies consacrées à cette pratique ont bondi de 90% au cours des sept (7) dernières années, passant de 1192 ha en 2018 à plus de 2300 ha en 2024. Nous avons également constaté que l'utilisation de ce paillis de plastique se concentrait sur certains secteurs, dont 44% sur des superficies ayant connu des utilisations annuelles répétées. Annuellement, c'est entre 1,3% et 2,5% de terres agricoles utilisées en grandes cultures qui sont maintenant couvertes par ce paillis de plastique dans la région. La littérature de même que nos observations sur le terrain indiquent également que ce plastique ne se décompose pas au rythme souhaité. Devant ce constat, des études devront être rapidement entreprises afin de trouver des solutions plus durables.