bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyol‐Intermediated Facile Synthesis of B5‐Site‐Rich Ru‐Based Nanocatalysts for COx‐Free Hydrogen Production via Ammonia Decomposition
Authors: Kim Kyoung Deok , Kim Jiyu , An Byeong‐Seon , Shin Jung Hun , Park Yongha , Jung Unho , Yi Kwang Bok , Koo Kee Young 
Published: December 2024

AbstractHerein, a B5‐site‐rich Ru/MgAl2O4 nanocatalyst for the production of COx‐free hydrogen from ammonia (NH3) is synthesized using the polyol method. The polyol method enables size‐sensitive Ru‐nanoparticle growth and controlled B5‐site formation on the catalyst by tuning the carbon‐chain length of the polyol solvent used, obviating the use of a separate stabilizer and enhancing electron donation from Ru (with a high surface electron density) and π‐back bonding. The Ru/MgAl2O4 (BG) catalyst synthesized using butylene glycol (a long‐carbon‐chain solvent) contains 2.5 nm Ru particles uniformly dispersed on its surface and abundant B5 sites at (0 0 2)/(0 1 1). Moreover, the Ru/MgAl2O4 (BG) catalyst exhibits lower activation energy (48.9 kJ mol−1) and higher H2 formation rate (565–1,236 mmol gcat−1 h−1 at 350−450 °C and a weight hourly space velocity of 30,000 mL gcat−1 h−1) during the NH3 decomposition reaction than catalysts with a similar Ru particle size and high metal dispersion synthesized by the impregnation and deposition–precipitation methods. This high performance is possibly because the abundant electron‐donating B5 sites on the catalyst surface accelerate the recombination–desorption of N2, which is the rate‐determining step of the NH3 decomposition reaction at low temperatures. Thus, this study facilitates clean hydrogen production.
Ultra‐High Performance Liquid Chromatography/Triple Quadrupole Ion‐Trap Mass Spectrometry‐Based Quantitative Assay of 17 Compounds to Unveil the Extraction Difference of Potentially Toxic Components Between the Single Drugs and Sishen Formula
Authors: Wang Meng‐yao , Hu Wan‐di , Lou Jia , Hong Li‐li , Yang Yi‐jin , Zhang Min , Chen Qin‐hua , Gao Xiu‐mei , Liu Er‐wei , Yang Wen‐zhi 
Published: December 2024

ABSTRACTSishen formula is a famous prescription utilized to treat kidney diarrhea. The main components of Psoraleae Fructus and Euodiae Fructus are reported with the liver toxicity; however, the dissolution difference of those reported toxic compounds among the single medicine decoctions and those versatile compatibility forms has yet not been documented by quantitative assays. We established and validated an ultra‐high performance liquid chromatography/triple quadrupole‐linear ion‐trap mass spectrometry‐multiple reaction monitoring approach by targeting 17 components (e.g., four coumarins and eight flavonoids from Psoraleae Fructus; three alkaloids and two limonoids from Euodiae Fructus). Co‐decoction with Myristicae Semen or Schisandrae Chinensis Fructus could significantly affect the dissolution of coumarins and flavonoids from Psoraleae Fructus, whereas a weak influence was observed for combining Euodiae Fructus with Psoraleae Fructus. Combination with Schisandrae Chinensis Fructus could significantly increase the contents of both alkaloids and limonoids of Euodiae Fructus, but the effect of Myristicae Semen or Psoraleae Fructus was relatively slight. Moreover, the dissolution of Psoraleae Fructus coumarins and Euodiae Fructus limonoids in Sishen formula was remarkably inhibited, compared with the pure Psoraleae Fructus decoction, whereas the variation was weak between the Euodiae Fructus decoction and Sishen formula. These results benefit the bridge to the efficacy and toxicity changes of Sishen formula.
Unveiling Drug Discovery Insights Through Molecular Electrostatic Potential Analysis
Authors: Haritha Mambatta , Suresh Cherumuttathu H. 
Published: December 2024

ABSTRACTMolecular electrostatic potential (MESP) analysis has emerged as a pivotal tool in drug discovery, providing insights into molecular reactivity and noncovalent interactions essential for drug function. While widely used MESP‐on‐isodensity surface analysis offers interpretations of electron‐rich or deficient regions of a drug molecule, the MESP topology parameters such as spatial minimum (Vmin) and MESP at nuclei (Vn) provide a quantitative understanding. The investigation into the correlation between MESP parameters and various molecular properties such as lipophilicity, pKa (acidity/basicity), conformations, and tautomeric forms is crucial for understanding the impact on biological activity of drugs and facilitating drug design. Moreover, MESP topology analysis serves as a fundamental tool in elucidating the pharmacological behavior of compounds and optimizing their therapeutic efficacy. A quantitative study utilizing Vn parameters to assess the hydrogen bond propensity of a drug presents a novel strategy for investigating drug‐receptor interactions with increased precision. The qualitative and quantitative analysis of the MESP features of various drugs, including their applications in cancer, tuberculosis, tumors, inflammation, and infectious diseases such as malaria, bacterial infections, fungal infections, and viral infections, is conducted in this review.
INTEGRAL Observing Time Proposals
Authors: Kuulkers Erik , Sánchez-Fernández Celia , Parmar Arvind 
Published: December 2024

AbstractWe examine the outcomes of the regular announcements of observing opportunities for ESA’s gamma-ray observatory INTEGRAL issued between 2000 and 2021. We investigate how success rates vary with the lead proposer’s gender, “academic age” and the country where the proposer’s institute is located. The more than 20 years operational lifetime enable the evolution of the community proposing for INTEGRAL to be probed. We determine proposal success rates for high-priority and all proposals using both the numbers of accepted proposals and the amounts of awarded observing time. We find that male lead proposers are between 2–11% more successful than their female counterparts in obtaining INTEGRAL observations. We investigate potential correlations between the female-led proposal success rates and the amount of female participation in the Time Allocation Committee.
Integration radiologischer Interventionen in der Notfallmedizin – wie multidisziplinäre Zusammenarbeit verbessert werden kann
Authors: Lorenz Julia , Spitznagel Nadja , Hidas Christine , Arrich Jasmin 
Published: December 2024

Zusammenfassung

Hintergrund
In der modernen Notfallmedizin ist es zunehmend möglich, interventionell-radiologische Verfahren anzuwenden. Von ischämischen Schlaganfällen bis hin zu lebensbedrohlichen Blutungen bieten diese Techniken neue Optionen zur schnellen, sicheren und effektiven Patient:innenversorgung. Jedoch erfordert der Einsatz dieser Verfahren im Vorfeld eine schnelle Diagnostik und interdisziplinäre Entscheidungsfindung, was eine präzise Koordination und klare Vorgehensweisen voraussetzt.

Ziel der Arbeit
Die Bedeutung der Etablierung von Behandlungspfaden für interventionell-radiologische Notfälle in der Notfallabteilung soll beleuchtet werden. Die Schritte zu ihrer Umsetzung werden aufgezeigt.

Material und Methoden
Diskussion existierender Studien und der bestehenden Praxis.

Ergebnisse
Eine gut koordinierte interdisziplinäre Zusammenarbeit ist entscheidend für die effektive Versorgung und den Einsatz interventionell-radiologischer Maßnahmen.

Schlussfolgerung
Die Entwicklung und Implementierung von Behandlungspfaden für Patient:innen mit Gefäßnotfällen ist entscheidend, um die Qualität der medizinischen Versorgung zu verbessern. Eine klare Koordination zwischen verschiedenen Fachbereichen, die Schaffung von Behandlungsprotokollen und die Schulung des Personals sind wichtige Schritte zur Gewährleistung einer effizienten Versorgung in Notfallsituationen.
Shielding properties of the kombucha-derived bacterial cellulose
Authors: Kołodziejczyk Agata M. , Silarski Michał , Kaczmarek Mateusz , Harasymczuk Mateusz , Dziedzic-Kocurek Katarzyna , Uhl Tadeusz 
Published: December 2024

Abstract
Living organisms are constantly exposed to cosmic, terrestrial, and internal sources of radiation. As a result, they have developed natural radioprotective mechanisms. However, in some cases, these mechanisms may not be sufficient. Elevated doses and prolonged exposure to radiation, such as during radiotherapy or in extreme environments like spaceflight, can cause damage to DNA and increase the abundance of reactive oxygen species, which can affect biological processes. In contrast to synthetic ingredients, naturally produced radioprotective materials have good biocompatibility and are easy to recycle. This work investigates the radioprotective properties of the hydrogel biofilm produced by the kombucha microbial consortium. The shielding properties of kombucha’s bacterial cellulose (KBC) were examined using gamma quanta with energies ranging from 122 to 1408 keV and an AmBe neutron source. The native form of KBC contains more than 80% water content. To enhance the radioprotection of kombucha’s biofilm, metallic components (K, Fe, Mxenes) and biological additives were tested. Rhodobacter sphaeroides and Synechocystis sp. PCC6803, which are resistant to oxidative stress, were added to the cultivation media. Physical properties were characterized using microscopy, ion leaching, and contact angle measurements. Post-processed dried KBC wristbands were analyzed for absorption parameters to enhance protective shielding. Possible levels of radioprotection for various types of bacterial cellulose thickness and forms were computed based on the obtained results. The findings encourage the use of bacterial cellulose in a circular economy for future bioregenerative systems.
Effect of sintering temperature and Sr/Ti ratio on the nature of Mn-ion speciation within SrTiO3-based compounds
Authors: Łącz Agnieszka , Gwóźdź Paulina , Mielniczuk Monika , Stępień Joanna , Drożdż Ewa 
Published: December 2024

Abstract
Manganese-doped (Mn/Ti = 0.02/0.98) SrTiO3-based materials with various Sr/Ti mole ratios (1.02, 1.00, 0.97 and 0.92) were obtained by the citrate precursor method. The materials were characterised in terms of microstructure (SEM), structure (XRD, XANES), electrical properties (DC method) and reducibility (TPR). With the introduction of 2 mol.% Mn, the cubic structure of SrTiO3 is preserved, but significantly limits (from Sr/Ti ≥ 0.8 to Sr/Ti > 0.92) the possibilities of deviations from stoichiometry at 1200°C. The narrowing of the stability limit of the perovskite structure to Sr/Ti > 0.97 with an increase in temperature to 1400°C and segregation of Ti-Mn-enrich species are shown. The location and the oxidation states of Mn in both (Sr and Ti) sublattices depend on the assumed Sr/Ti ratio and sintering temperature. Regardless of the Sr/Ti ratio, Mn-doped SrTiO3 exhibits very low electrical conductivity with an ionic conductivity mechanism.

Graphical abstract
Density modulo 1 and Hardy fields
Authors: Abramoff Michel , Berend Daniel , Kolesnik Grigori 
Published: December 2024

AbstractIn this article we extend Boshernitzan’s result on density modulo 1 of sequences arising from functions belonging to a Hardy field. We also merge these results with Furstenberg’s ×2×3 theorem. We prove, for example, that, given a vector f of subpolynomial functions in a Hardy field, such that $$(\mathbf{f}(n))_{n=1}^{\infty}$$
(

f

(
n
)

)

n
=
1

∞

is dense modulo 1 in Rd, the sequence (2m3nα, f(n))m,n≥1 is dense modulo 1 in Rd+1 for irrational α. Some negative results concerning Furstenberg’s theorem are obtained as well.
Clinical expert consensus document on bailout algorithms for complications in percutaneous coronary intervention from the Japanese Association of Cardiovascular Intervention and Therapeutics
Authors: Ogawa Takayuki , Sakakura Kenichi , Sumitsuji Satoru , Hyodo Makoto , Yamaguchi Junichi , Hirase Hiroaki , Yamashita Takehiro , Kadota Kazushige , Kobayashi Yoshio , Kozuma Ken 
Published: December 2024

AbstractThe efficacy and safety of percutaneous coronary intervention (PCI) for coronary artery disease has been established, and approximately 250,000 PCI procedures are performed annually in Japan. However, various complications including life-threatening complications can occur during PCI. Although several bailout procedures have been proposed to address complications during PCI, it is critically important for operators to manage each complication in real catheter rooms with confidence even in emergent situations. Standard bailout methods including specific techniques should be clarified as algorithms and shared with inexperienced operators as well as experienced operators. The Task Force of the Japanese Society for Cardiovascular Intervention and Therapeutics (CVIT) has developed the expert consensus document on bailout algorithms for complications in PCI.
Organisationale Gesundheitskompetenz und deren Bedeutung für Unternehmen
Authors: Marquardt Berit , Mache Stefanie 
Published: December 2024

Zusammenfassung
Hintergrund
Die heutige Arbeitswelt verändert sich rasant und stellt erhöhte Anforderungen an Organisationen und deren Beschäftigte. Für Unternehmen ist daher eine gesunde und leistungsfähige Belegschaft zentral, die gesundheitskompetente Entscheidungen treffen kann. Dafür braucht es entsprechende ganzheitliche Rahmenbedingungen vonseiten der Organisation. Nur im Zusammenspiel von Individuum und Unternehmen können die bestehenden Herausforderungen bewältigt werden.
Diese Literaturübersicht widmet sich der Frage, wie sich organisationale Gesundheitskompetenz von anderen verhältnisbezogenen Konstrukten abgrenzt. Zudem wird die aktuelle Studienlage zum Zusammenhang von organisationaler und individueller Gesundheitskompetenz in Unternehmen außerhalb der Gesundheitsversorgung erforscht.

Methodik
Mithilfe einer explorativen Literaturrecherche unter Verwendung eines systematischen Suchansatzes wurde in 20 unterschiedlichen Informationsmedien (7 Datenbanken, 9 Zeitschriften und 4 Bibliotheken) nach Veröffentlichungen zum Zusammenhang von organisationaler und individueller Gesundheitskompetenz in Unternehmen außerhalb der Gesundheitsversorgung gesucht.

Ergebnisse
Wie gezeigt werden kann, handelt sich bei dem Konstrukt der organisationalen Gesundheitskompetenz um ein komplexes und heterogen konzipiertes Phänomen. Hinzu kommt, dass im Setting der Arbeitswelt außerhalb der Gesundheitsversorgung nur eine begrenzte Anzahl an Ansätzen vorliegt. Bei diesen fällt im Vergleich auf, dass sowohl Gemeinsamkeiten als auch Unterschiede, z. B. hinsichtlich der Gesundheitsoutcomes, bestehen. Dennoch können die Ansätze nicht durchgehend eindeutig voneinander differenziert werden. Gemäß aktuellen Studienerkenntnissen wird der Zusammenhang zwischen individueller Gesundheitskompetenz und psychischem Wohlbefinden durch die organisationale Gesundheitskompetenz vermittelt.

Schlussfolgerung
Die Ergebnisse verdeutlichen den defizitären Forschungsstand zur Konzeption und zu gesundheitlichen Zusammenhängen. Es bedarf zukünftig weiterer Forschungsbemühungen, um das Verständnis von organisationaler Gesundheitskompetenz im Unternehmen außerhalb der Gesundheitsversorgung zu schärfen und die komplexen Zusammenhänge zwischen der Gesundheitskompetenz von Organisationen und Individuen zu verstehen. Nur so kann die Gesundheit im Unternehmen verhältnisbezogen gefördert werden.
Effects of a daylight intervention in the morning on circadian rhythms and sleep in geriatric patients: a randomized crossover trial
Authors: Schubert Anna , Laurentius Thea , Lange Svenja , Bertram Jens , Bollheimer Leo Cornelius , Schweiker Marcel , Christoforou Rania 
Published: December 2024

Abstract

Purpose
During hospitalization, circadian rhythms and sleep are often disrupted, which has negative effects on health outcomes. Therefore, we aimed to investigate whether a daylight intervention in the morning could improve the circadian rhythms of cortisol and melatonin and enhance objective and subjective sleep quality in geriatric patients.

Methods
The present study is a randomized, two-period crossover trial conducted in a geriatric ward in 15 non-demented geriatric trauma patients with a mean age of 83.1 ± 5.4 years. All patients underwent a daylight intervention period, during which they were exposed to a daylight lamp from 8:00 to 13:00 h, and a control period of 6 days each. Cortisol and melatonin levels were measured on day 5 of each period. Objective and subjective sleep quality were assessed using actigraphy and questionnaires, respectively. Within-participant differences between periods were investigated for all parameters.

Results
A trend towards improvement in cortisol and melatonin rhythmicity was found. An increase in mean melatonin levels from 0.3 ± 0.1 to 0.9 ± 0.8 ng/L was observed during the intervention period (p = .063). There was also a trend towards increased sleep efficiency, whereas subjective sleep quality tended to decrease. None of the results were significant.

Conclusion
A daylight intervention in the morning led to a positive trend in cortisol and melatonin rhythmicity, whereas no improvement in subjective sleep quality was found.

Trial registration
DRKS00028626 at German Clinical Trials Register, 13.06.2022.
An approach to select between the plausible kinetic models of a heterogeneous catalytic process using intraparticle diffusion with external mass transfer resistance
Authors: Zhokh O. O. , Strizhak P. E. 
Published: December 2024

AbstractThe reaction rate is sometimes thoroughly described by several kinetic models simultaneously. In this case, the discrimination of the particular model may be challenging. Herein, we demonstrate that a change in the rate-limiting step of a reaction mechanism may result in a significant deviation of the effectiveness factor even if the kinetic rate equations provide nearly identical reaction rates. On this basis, the comparison of the experimental effectiveness factor and the effectiveness factor calculated theoretically using the corresponding rate equations may shed light on the true reaction mechanism. Since many industrial processes operate under internal and external mass transfer limitations, the effectiveness factor is obtained by accounting for pore diffusion resistance and diffusion resistance at the outer surface of a catalyst particle. Verification of the obtained formalism is performed using the kinetic constants for the commercially available process of the methanol dehydration to dimethyl ether over γ-alumina catalyst.
Building and sustaining a laparoscopic simulation curriculum in Dar es Salaam, Tanzania
Authors: Akoko Larry , Mwanga Ali , Wibonela Seif , Brian Riley , Jarry Cristian , Montero Isabella , Selman Rafael , Escalona Gabriel , Philipo Godfrey Sama , Ozgediz Doruk , Alseidi Adnan , Varas Julian , Brand Nathan R 
Published: December 2024

Abstract
Purpose
Although laparoscopy has transformed surgical care in high-income countries, access remains limited in Africa. This calls for tailored laparoscopic education in such contexts to enable the training necessary to expand laparoscopic surgery. We aimed to describe the implementation, evaluation, and sustainability of a laparoscopic simulation lab in Dar es Salaam, Tanzania.

Methods
We founded a laparoscopic simulation lab at Muhimbili University of Health and Allied Sciences (MUHAS) and implemented a simulation curriculum. We conducted a prospective curricular evaluation focusing on both process and outcome metrics.

Results
We established laparoscopic simulation training at MUHAS. This entailed securing a dedicated space, equipping the laboratory, and training a lab manager to be a simulation educator. Fifty-one participants completed 1,909 h of laparoscopic training at the simulation lab and received 3,940 individual pieces of online feedback. Analysis of task completion times and performance showed improvement in all tasks in pre-test task videos compared to final task videos. Nine of 20 graduates responding to a questionnaire (45%) actively performed laparoscopic surgery within their institutions. Among these respondents, all felt that participating in LAPP was very helpful or essential to their practice.

Conclusions
We implemented a laparoscopic curriculum at a new simulation lab in Tanzania. Residents, fellows, and faculty from across Tanzania dedicated substantial time and effort over more than 18 months to complete the curriculum, improve their laparoscopic skills, and change their operative practices. This report may serve as a blueprint for those looking to implement, evaluate, and sustain curricula in similar settings.
A scintillating fiber imaging spectrometer for active characterization of laser-driven proton beams
Authors: Patel J. K. , Armstrong C. D. , Wilson R. , Alderton M. , Dolier E. J. , Frazer T. P. , Horne A. , Lofrese A. , Peat M. , Woodward M. , Zielbauer B. , Clarke R. J. , Deas R. , Rajeev P. P. , Gray R. J. , McKenna P. 
Published: December 2024

Abstract
Next generation high-power laser facilities are expected to generate hundreds-of-MeV proton beams and operate at multi-Hz repetition rates, presenting opportunities for medical, industrial and scientific applications requiring bright pulses of energetic ions. Characterizing the spectro-spatial profile of these ions at high repetition rates in the harsh radiation environments created by laser–plasma interactions remains challenging but is paramount for further source development. To address this, we present a compact scintillating fiber imaging spectrometer based on the tomographic reconstruction of proton energy deposition in a layered fiber array. Modeling indicates that spatial resolution of approximately 1 mm and energy resolution of less than 10% at proton energies of more than 20 MeV are readily achievable with existing 100 μm diameter fibers. Measurements with a prototype beam-profile monitor using 500 μm fibers demonstrate active readouts with invulnerability to electromagnetic pulses, and less than 100 Gy sensitivity. The performance of the full instrument concept is explored with Monte Carlo simulations, accurately reconstructing a proton beam with a multiple-component spectro-spatial profile.
Analysis of diagnostic criteria for ECMO-associated pneumonia
Authors: England Julie , Lee Rachael , Marshall Tammy , Xie Rongbing , Blood Peggy , Wille Keith , Gongora Enrique , Nellore Anoma , Kirklin James K. , Walker Jeremey 
Published: December 2024

AbstractVentilator-associated pneumonia (VAP) is a well-established cause of morbidity in critically ill patients. Current VAP criteria exclude patients on extracorporeal membrane oxygenation (ECMO). This retrospective analysis tests the validity of VAP in this population, as well as a new proposed diagnostic criterion for ECMO-associated pneumonia.
On the Brownian range and the Brownian reversal
Authors: Li Yifan 
Published: December 2024

Abstract
This paper studies a novel Brownian functional defined as the supremum of a weighted average of the running Brownian range and its running reversal from extrema on the unit interval. We derive the Laplace transform for the squared reciprocal of this functional, which leads to explicit moment expressions that are new to the literature. We show that the proposed Brownian functional can be used to estimate the spot volatility of financial returns based on high-frequency price observations.