bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral lymphoma: a case series
Authors: Allsobrook Olive FL , Bakri Issam , Farthing Paula M , Morley Nick J , Hegarty Anne M 
Published: July 2018

Abstract: Oral presentation of lymphoma is rare but highlights the need for dentists in primary care to consider it for inclusion when determining differential diagnoses for patients who present with oral lesions. Oral lymphoma manifests in both intra- and extra-osseous sites within the oral cavity with a variety of clinical appearances which may mimic benign or innocuous processes. There may be non-specific signs which may be misleading to the clinician or present mimicking other oral malignancies, such as a non-healing ulcer, rapidly growing swelling with sudden onset or dental pathological processes. This case series highlights the varied presentations of oral lymphoma and the role of general dental practitioners in the early diagnosis, timely referral and management of these patients. CPD/Clinical Relevance: This article highlights the need for primary care clinicians to consider oral lymphoma in patients who present in the general dental setting with oral lesions.
Oral rehabilitation of a patient suffering mal-union of a fractured mandible
Authors: Bryce Graeme , Sterlitz Stephen , Smith Stephen 
Published: July 2018

Abstract: Mandibular mal-union following fracture is a rare occurrence that can normally be surgically corrected. This article reviews the aetiology of mal-union and details the restorative rehabilitation of a patient suffering a failing dentition and mal-union of the mandible, using dental implants. CPD/Clinical Relevance: This article discusses the restorative challenges with managing a patient with mandibular mal-union and details a successful treatment pathway using dental implants.
3D printed tooth model – a patient education tool and surgical aid in endodontics
Authors: Arora Ankit , Mody Bharat , Patel Niraj 
Published: July 2018

Abstract: The use of 3D printed models created using cone beam computed tomography (CBCT) is a new addition to the field of dentistry. 3D printed models are easier for the patients to understand and serve as an effective treatment planning tool for the clinician. This case describes 3D printing as a technique which not only aids in visualization of the complex anatomy but serves as a great motivational and educational tool. A tooth with dens invaginatus and chronic apical periodontitis requiring surgical intervention was printed and used for patient motivation and three-dimensional visualization, which improved the accuracy of diagnosis, treatment planning, predictability of procedures and final outcome. CPD/Clinical Relevance: 3D printed models can be utilized as a patient education tool for motivating patients who are not convinced by the surgical treatment modality.
Malignant oral melanoma: how to spot it and how it is managed
Authors: Khan Zahid , Albuquerque Rui , Richards Andrea 
Published: July 2018

Abstract: Primary oral melanoma (POM) is a rare malignancy affecting primarily the hard palate and maxillary gingivae. Oral melanoma has a poor prognosis due to the frequent delay in diagnosis, the tendency of the tissues to be invaded locally and the potential to metastasize. This article aims to summarize the key clinical features of different types of oral pigmentation that are likely to be encountered by a general dental practitioner (GDP) and to highlight those that should prompt an urgent referral for investigation. CPD/Clinical Relevance: The aim of this article is to increase awareness of the varying and sometimes atypical features of oral melanoma.
The Exeter V40 cemented femoral component at a minimum 10-year follow-up
Authors: Westerman R. W. , Whitehouse S. L. , Hubble M. J. W. , Timperley A. J. , Howell J. R. , Wilson M. J. 
Published: July 2018

Aims The aim of this study was to report the initial results of the Exeter V40 stem, which became available in 2000. Patients and Methods A total of 540 total hip arthroplasties (THAs) were performed in our unit using this stem between December 2000 and May 2002. Our routine protocol is to review patients postoperatively and at one, five, and ten years following surgery. Results A total of 145 patients (26.9%) died before ten years and of the remaining 395 stems, 374 (94.7%) remain in situ. A total of 21 well-fixed stems (5.3%) were revised. Ten were exchanged using a cement-in-cement technique to facilitate acetabular revision. Three were revised for infection, one for instability, one for fracture of the stem, and six following a periprosthetic fracture. An additional 16 acetabular components (4.1%) were revised; five for aseptic loosening and 11 for instability. There were no revisions for aseptic loosening of the stem, and no evidence of aseptic loosening in any hip. The fate of every stem is known and all patients remain under review. Survivorship, with revision of the stem for aseptic loosening as the endpoint, was 100%. At 13.5 years, the Kaplan–Meier survival rate for all-cause revision of the stem was 96.8% (95% confidence interval (CI) 94.8 to 98.8) and all-cause revision (including acetabular revision, infection, and instability) was 91.2% (95% CI 88.3 to 94.1). Conclusion No stem was revised for aseptic loosening in this series. The contemporary Exeter V40 stem continues to perform well, and survival has remained comparable with that of the Exeter Universal stem. Cite this article: Bone Joint J 2018;100-B:1002–9.
A randomized controlled trial of cementedversuscementless arthroplasty in patients with a displaced femoral neck fracture
Authors: Barenius B. , Inngul C. , Alagic Z. , Enocson A. 
Published: July 2018

AimsThe aim of this study was to compare the functional and radiological outcomes in patients with a displaced fracture of the hip who were treated with a cemented or a cementless femoral stem.Patients and MethodsA four-year follow-up of a randomized controlled study included 141 patients who underwent surgery for a displaced femoral neck fracture. Patients were randomized to receive either a cemented (n = 67) or a cementless (n = 74) stem at hemiarthroplasty (HA; n = 83) or total hip arthroplasty (THA; n = 58).ResultsEarly differences in functional outcome, assessed using the Harris Hip Score, the Short Musculoskeletal Functional Assessment score and EuroQol-5D, with better results in cemented group, deteriorated over time and there were no statistically significant differences at 48 months. Two (3%) patients in the cemented group and five (6.8%) in the cementless group underwent further surgery for a periprosthetic fracture. This difference was statistically significant (p = 0.4). No patient underwent further surgery for instability or infection between one and four years postoperatively. The mortality and the radiological outcomes were similar in both groups.ConclusionPatients with a displaced femoral neck fracture treated with an arthroplasty using a cemented or cementless stem had good function and few complications up to four years postoperatively. However, due to the poor short-term functional outcomes in the cementless group, the findings do not support their routine use in the treatment of these elderly patients. Cite this article: Bone Joint J 2018;100-B:1087–93.
Total disc replacement versus anterior cervical discectomy and fusion
Authors: Findlay C. , Ayis S. , Demetriades A. K. 
Published: July 2018

Aims The aim of this study was to determine how the short- and medium- to long-term outcome measures after total disc replacement (TDR) compare with those of anterior cervical discectomy and fusion (ACDF), using a systematic review and meta-analysis. Patients and Methods Databases including Medline, Embase, and Scopus were searched. Inclusion criteria involved prospective randomized control trials (RCTs) reporting the surgical treatment of patients with symptomatic degenerative cervical disc disease. Two independent investigators extracted the data. The strength of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria. The primary outcome measures were overall and neurological success, and these were included in the meta-analysis. Standardized patient-reported outcomes, including the incidence of further surgery and adjacent segment disease, were summarized and discussed. Results A total of 22 papers published from 14 RCTs were included, representing 3160 patients with follow-up of up to ten years. Meta-analysis indicated that TDR is superior to ACDF at two years and between four and seven years. In the short-term, patients who underwent TDR had better patient-reported outcomes than those who underwent ACDF, but at two years this was typically not significant. Results between four and seven years showed significant differences in Neck Disability Index (NDI), 36-Item Short-Form Health Survey (SF-36) physical component scores, dysphagia, and satisfaction, all favouring TDR. Most trials found significantly less adjacent segment disease after TDR at both two years (short-term) and between four and seven years (medium- to long-term). Conclusion TDR is as effective as ACDF and superior for some outcomes. Disc replacement reduces the risk of adjacent segment disease. Continued uncertainty remains about degeneration of the prosthesis. Long-term surveillance of patients who undergo TDR may allow its routine use. Cite this article: Bone Joint J 2018;100-B:991–1001.
Venous Thromboembolism: Role of the Clinical Laboratory in Diagnosis and Management
Authors: Parakh Rugvedita S , Sabath Daniel E 
Published: July 2018

Abstract

Background
Venous thromboembolism (VTE) is the third most common cause of cardiovascular illness and is projected to double in incidence by 2050. It is a spectrum of disease that includes deep venous thrombosis (DVT) and pulmonary embolism (PE). In February 2016, the American College of Chest Physicians provided updated management guidelines for DVT and PE to address some of the unresolved questions from the previous version and to provide recommendations related to newer anticoagulants.

Content
Here we review current concepts for screening, diagnosis, thromboprophylaxis, and management of DVT and PE. We also describe the management of VTE in acute, long-term, and extended phases of treatment. Thrombophilia testing is rarely necessary and should be used judiciously; the laboratory can serve an important role in preventing unnecessary testing. The direct oral anticoagulants are as effective as conventional treatment and are preferred agents except in the case of cancer. The initial management of PE should be based on risk stratification including the use of D-dimer testing. Thrombolysis is used in cases of hemodynamically unstable PE and not for low-risk patients who can be treated on an outpatient basis.

Summary
This review is intended to provide readers with updated guidelines for screening, testing, prophylaxis, and management from various organizations.
The thickness of the epicardial fat is the "visit card" of metabolic syndrome
Authors: Drapkina Oxana M , Shepel Ruslan N , Deeva Tatiana A 
Published: July 2018

AIMS. On the basis of echocardiography to evaluate the thickness of epicardial fat (TEF) in patients with metabolic syndrome (MS) and to establish a connection with the main indicators of laboratory and instrumental methods of research.
MATERIALS AND METHODS. The study included 76 patients, 43 patients with MS and 33 without MS. The average age of patients in the MS group at the time of inclusion in the study was 62.7±10.3 years in the control group (without MS) – 60±14.7 years. All patients underwent a comprehensive examination that included the collection of complaints, study of history, physical examination, anthropometric measurements, laboratory (including the study of the levels of caspase – 8, leptin in blood plasma enzyme-linked immunosorbent assay using kits «Platinum ELISA») and instrumental examination (echocardiography, ultrasound examination of organs of small pelvis). TEF was determined using transthoracic echocardiography on the machine Acuson Sequoia 512.
RESULTS. According transthoracic echocardiography was significantly higher in the group of patients with MS and was 4.67±1.7 mm, as compared to 2.66±1.15 mm in the control group (p<0.001). Identified moderate and strong correlation between TEF and weight of the patients, waist circumference, ratio of waist circumference to hip circumference, body mass index, glucose levels in the blood plasma, the presence of diabetes mellitus type 2, ultrasonic signs of steatosis of the liver and pancreas, increased aminotransferases, the level of caspase-8 concentration in plasma leptin. Patients the MS group with increased TEF increases the risk of developing hypertension, ischemic heart disease, left ventricular hypertrophy, diastolic dysfunction of the left ventricle type 2, level of caspase-8 and concentration in plasma leptin.
CONCLUSION. Based on the obtained data, the measurement of TEF is justified in patients with MS in everyday clinical practice. The correlations between the TEF and the clinical and metabolic parameters of the CVD and MS make it possible to consider the TEF as a new marker of the risk of developing MS and cardiovascular diseases.
Therapy of obesity by sibutramin: polymorphisms of TPH2 and GNB3 genes and decrease of body weight
Authors: Galieva Marina O , Troshina Ekaterina A , Mazurina Nataliya V , Volynkina Anna P , Artiushin Andrey , Pavlova Anastasia S 
Published: July 2018

AIMS. To study of the polymorphisms of the TPN2 and GNB3 genes in obese patients and their effect on weight loss in patients on sibutramine therapy.
MATERIALS AND METHODS. The research study included 118 patients with exogenous-constitutional obesity who received Reduxin (sibutramine + CMC) at the dose of 10 mg. Term follow-up was 3 months. A genetic study was performed to assess ТРН2 and GNB3 gene polymorphisms. The response to the therapy was evaluated after 3 months by the dynamics of body weight.
RESULTS. In the study the G703T polymorphism of the GNB3 gene showed that during 3 months of observation, carriers of the TT genotype had a greater decrease in body weight in comparison with carriers of the allele C – -8 kg (-12; -5) vs. -5 kg (-8; -3), p = 0.018. In carriers of different variants of the genotype of the TPH2 gene (polymorphism C825T), there was no difference in body weight dynamics with sibutramine therapy. There was no correlation between the foresaid polymorphisms of the TPH2 and GNB3 genes with the indices of blood pressure and heart rate.
CONCLUSIONS. 1. The result of sibutramin therapy may depend on genetic factors: in carriers of the TT-genotype C825T of the GNB3 gene the body weight loss was higher than among the carriers of the C allele. 2. Changes in blood pressure and heart rate did not show any statistically significant relationship with polymorphisms of the TPH2 and GNB3 genes.
Patients Satisfaction Based on Corporate Entrepreneurship
Authors: Tri Ratnasaria Ririn , Prasetyo Ari , Kurniawati Masmira , Fajar Cahyono Eko 
Published: July 2018

This research aim to determine what factors are included in the service excellence based on corporate entrepreneurship, whether these factors affect the patient satisfaction, and which factors that influencing dominantly to patient satisfaction. The research design of this study is exploratory quantitative approach, which is conducted in two stages. The first step, the research conducted by open-ended question to explore the perception of the 40 patients about the service excellence of the hospital, so it can be known the factors which include in service excellence based on corporate enterpreneurship can be developed in the improvement of health services at the Dr. Soetomo Hospital after the implementation of BPJS, then proceed with a structure close-ended question to 400 patient of Health-BPJS. The sampling technique was by purposive non-random sampling. The result of this study are, first, factors affecting patient satisfaction of Health-BPJS participant after get treatment at the government hospital (Dr. Soetomo Hospital and Hajj Public Hospital) formed by six factors. Factors that formed was named by the reliability factor, empathy factor, the factor means of support, administrative factors, service factors, and factors of hospital hygiene. Second, indicators with the highest loading values obtained from the rotation calculation factors are indicators of X13 on the reliability factor is the health services infrastructure supported by sophisticated technology.
Applications of Thermoregulation Adaptive Technique of form in Nature into Architecture: A Review
Authors: Abdullah Amatalraof , Bin Said Ismail , Remaz Ossen Dilshan 
Published: July 2018

In the last 20 years, biology has obviously been the source of countless, innovative solutions from nature in many discipline. Biomimetic is an interesting philosophy which hybrids multi-disciplinary sciences with biology. Biomimetic design is currently one of the promising fields ranging from accessing to adaptive, sustainable and energy saving solutions for the architectural and environmental challenges. This paper underlines and reviews the recent state of the art biomimetic applications to architecture, in particular, thermoregulation strategies. The review design was based on project’s status that varies from executed projects, experimental models and design concepts. The study shows that biomimicking thermoregulation strategies of the nature leads to a significant energy saving and indoor thermal comfort. It is also observed that some of the architectural researches in this regard do not exceed the stage of theoretical study due to the lack of sponsorship and funding. Although there is a number of levels in respect to mimicking adaptive notions from nature such as behavioral, physiological, and morphological, architects’ works are mostly confined to mimicking the functional performance of organism through its morphological configuration; physiological and morphological adaptation. The review shows that architects turn noticeably to nature’s solutions as the source of zero-waste system, saving energy and controlling thermal environment.
Malaysian People Financial Prosperity
Authors: Ismail Fadillah , Ismail Zuhaimy , Azhar Abd Hamid Mohd. , Mohamad Ismail , Abdul Kadir Adibah , Thukiman Kassim 
Published: July 2018

During the first sitting of the fifth term of the 13th Malaysian Parliament, The Yang di-Pertuan Agong Sultan Muhammad V pledged to reign in a just and fair manner by placing the well-being of the people and prosperity of the nation above all else. Thus it becomes the task of the Malaysian Government which includes the financial prosperity of the people. This paper aims at identifying the level of financial prosperity of Malaysian people. It has been identified that financial prosperity is a major problems among Malaysians, a result obtained from a survey research with 2000 samples taken from the whole country which is in accordance with the standards set by the International Statistical Institute [ISI]. The data collected were analyzed using various statistical methods and one of the method used to determine the people financial prosperity or financial well-being is by using index, namely the Malaysian People Satisfaction Index [MPSI]. We categorized the financial prosperity into four levels, namely the poor income, moderate income, good income and excellent income. The survey results show that the level of financial prosperity for Malaysian people is 49.6% with a mean of 4.88 which is categorized as moderate income. Further analysis shows that there are significant differences between the respondents' demographic factors and the financial prosperity. This shows that the government and relevant agencies need to play a more significant role to ensure the policies that are enacted can contribute to the well-being of the people. It would just be very difficult for Malaysia to become a developed nation by 2020 if the status of financial prosperity or financial well-being of its people is still at moderate level income.
Odwołania do idei cykliczności w filmie „Wygnanie” Andrieja Zwiagincewa
Authors: Przybysz Anna Katarzyna 
Published: July 2018

The aim of this article is to show how the idea of cyclicality functions in the artistic world of The Banishment, directed by Andrei Zvyagintsev. We try to show that this idea works in conjunction with biblical motifs, but is also visible in a broader mythical-anthropological context. This idea is inseparably linked with the motive of the border, which is floating by its nature. We also try to put emphasis on the Zvyagintsev’sartistic method.
Стилізація в українській і польській літературі постмодернізму
Authors: Kropyvko Irina 
Published: July 2018

Postmodern styling of text in another language (work, genre, time) lacks the assessment direction and is used as a conceptual and stylistic device. The article aims to define the styling features as the art-techniqe in postmodern texts of Polish and Ukrainian writers. The specificity of styling them is connected with the appeal of authors to artistic and non-fiction genres as the sources of formal originality of their texts. Ukrainian and Polish literature show quantitative connection between the structural parts of the text as the manifestation of the impact of the beyond-subjective world of information systems on a literary work concept. Impersonality highlights the lackof creative writer’s invention to literary text composing and appears to create the narrative illusion of uniform electronic signals or stylization on a computer text. A text resembling music genres forms a specific rhythmic pattern of fragmented pieces through the use of graphical ways to display pauses. Graphic design and structuring of the text are included in its overall concept, which is driven by current trends, such as specific life of the postmodern man and the destruction of boundaries between different types of activities (information, literary and artistic performance). Styling as the “image technology” of postmodern literary text adjusts it to some readers' tastes and / or determines the originality of its formal concept to improve its “consumer” qualityin order to meet the demanding modern reader’s expectations. These examples represent only a part of the author's choices experimenting with the structure of the text and its design, which is rooted in our reality distorted by globalization processes.