bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambient Condition Production of High Quality Reduced Graphene Oxide
Authors: Evlashin Stanislav A. , Svyakhovskiy Sergey E. , Fedorov Fedor S. , Mankelevich Yuri A. , Dyakonov Pavel V. , Minaev Nikita V. , Dagesyan Sarkis A. , Maslakov Konstantin I. , Khmelnitsky Roman A. , Suetin Nikolay V. , Akhatov Iskander S. , Nasibulin Albert G. 
Published: June 2018

AbstractReduced graphene oxide (GO) becomes one of the most popular materials for applications in various optical, electronic, and sensor devices. Even though many methods are already reported for reduced graphene oxide synthesis, they usually raise issues related to their efficiency, quality, and environmental impact. This work demonstrates a simple, environmental friendly, and effective method for reducing graphene oxide under ambient conditions using nanosecond infrared laser irradiation. As a result, a Raman band intensity ratio of I(G)/I(D) of 4.59 is achieved with an average crystallite size of ≈90 nm. This graphene is of higher quality than what can be achieved with most of the existing methods. Additionally, the demonstrated reduction technique allows the selective reduction of graphene oxide and control the amount of functional groups on the surface of the material. Gas sensors fabricated according to the proposed technique efficiently detect NO2, NH3, and H2S with the sensitivity down to 10 ppm.
Effects of H1 antihistamine addition to intranasal corticosteroid for allergic rhinitis: a systematic review and meta‐analysis
Authors: Seresirikachorn Kachorn , Chitsuthipakorn Wirach , Kanjanawasee Dichapong , Khattiyawittayakun Likhit , Snidvongs Kornkiat 
Published: June 2018

BackgroundA combination of H1 antihistamine (AH) with intranasal corticosteroid (INCS) is commonly prescribed to patients with allergic rhinitis (AR) who have an inadequate response to monotherapy. In this systematic review we aimed to determine the effects of AH combined with INCS (AH‐INCS) for treating AR.MethodsLiterature searches were performed using Medline and Embase. Randomized, controlled trials that studied the effects of AH‐INCS vs INCS monotherapy for treating patients with AR were included. The primary outcomes were total nasal symptom scores, total ocular symptom scores, and disease‐specific quality of life. The secondary outcomes were objective tests for nasal patency and adverse events.ResultsSixteen studies (4026 patients) met the inclusion criteria. Compared with INCS, AH‐INCS decreased total nasal symptom scores (standardized mean difference [SMD], −0.13; 95% confidence interval [CI], −0.19 to −0.06; p < 0.001; 10 trials, 3348 patients) and total ocular symptom scores (SMD, −0.12, 95% CI, −0.20 to −0.04; p = 0.003; 6 trials, 2378 patients). Subgroup analysis indicated no benefit with the oral AH‐INCS combination but did show benefit with intranasal AH‐INCS (SMD, −0.18; 95% CI, −0.27 to −0.09; p < 0.001). There were no significant differences with regard to disease‐specific quality of life (SMD, −0.07; 95% CI, −0.16 to 0.02; p = 0.12; 6 trials, 1981 patients), nasal inspiratory flow (MD, −0.03 L/min; 95% CI, −0.57 to 0.50; p = 0.91; 1 trial, 54 patients), or adverse events.ConclusionIntranasal AH‐INCS has benefit over INCS on nasal and ocular symptom improvement for treating AR. Oral AH‐INCS is not recommended.
Carbon Nanosheets by Morphology‐Retained Carbonization of Two‐Dimensional Assembled Anisotropic Carbon Nanorings
Authors: Mori Taizo , Tanaka Hiroyuki , Dalui Amit , Mitoma Nobuhiko , Suzuki Kengo , Matsumoto Mutsuyoshi , Aggarwal Nikhil , Patnaik Archita , Acharya Somobrata , Shrestha Lok Kumar , Sakamoto Hirotoshi , Itami Kenichiro , Ariga Katsuhiko 
Published: June 2018

AbstractTwo‐dimensional (2D) carbon nanomaterials possessing promising physical and chemical properties find applications in high‐performance energy storage devices and catalysts. However, large‐scale fabrication of 2D carbon nanostructures is based on a few specific carbon templates or precursors and poses a formidable challenge. Now a new bottom‐up method for carbon nanosheet fabrication using a newly designed anisotropic carbon nanoring molecule, CPPhen, is presented. CPPhen was self‐assembled at a dynamic air–water interface with a vortex motion to afford molecular nanosheets, which were then carbonized under inert gas flow. Their nanosheet morphologies were retained after carbonization, which has never been seen for low‐molecular weight compounds. Furthermore, adding pyridine as a nitrogen dopant in the self‐assembly step successfully afforded nitrogen‐doped carbon nanosheets containing mainly pyridinic nitrogen species.
Enantioselective Synthesis of (−)‐Halenaquinone
Authors: Goswami Subir , Harada Kenichi , El‐Mansy Mohamed F. , Lingampally Rajinikanth , Carter Rich G. 
Published: June 2018

AbstractThe efficient, 12–14 step (LLS) total synthesis of (−)‐halenaquinone has been achieved. Key steps in the synthetic sequence include: (a) proline sulfonamide‐catalyzed, Yamada–Otani reaction to establish the C6 all‐carbon quaternary stereocenter, (b) multiple, novel palladium‐mediated oxidative cyclizations to introduce the furan moiety, and (c) oxidative Bergman cyclization to form the final quinone ring.
A Peapod‐like CoP@C Nanostructure from Phosphorization in a Low‐Temperature Molten Salt for High‐Performance Lithium‐Ion Batteries
Authors: Liu Zhiliang , Yang Sungjin , Sun Bingxue , Chang Xinghua , Zheng Jie , Li Xingguo 
Published: June 2018

AbstractA mild phosphorization process in low‐temperature molten salt (NaCl‐KCl‐AlCl3) has been developed to synthesize peapod‐like CoP@C nanostructures by using low‐toxicity industrial PCl3 as the phosphorus source and Mg as the reductant at 250 °C. Importantly, high efficiency of the phosphorous source is achieved since only stoichiometric PCl3 is required to complete the reaction. The molten NaCl‐KCl‐AlCl3 not only provides a liquid environment but also participates in the electron transport by the reversible conversion of the Al3+/Al redox couple. The obtained 0D‐in‐1D peapod CoP@C structure exhibits excellent lithium storage performance, delivering a superiorly stable capacity of 500 mAh g−1 after 800 cycles at a high current of 1.0 A g−1.
High‐Throughput Design of Biocompatible Enzyme‐Based Hydrogel Microparticles with Autonomous Movement
Authors: Keller Shauni , Teora Serena P. , Hu Guo Xun , Nijemeisland Marlies , Wilson Daniela A. 
Published: June 2018

AbstractMicro‐ and nanomotors and their use for biomedical applications have recently received increased attention. However, most designs use top‐down methods to construct inorganic motors, which are labour‐intensive and not suitable for biomedical use. Herein, we report a high‐throughput design of an asymmetric hydrogel microparticle with autonomous movement by using a microfluidic chip to generate asymmetric, aqueous, two‐phase‐separating droplets consisting of poly(ethylene glycol) diacrylate (PEGDA) and dextran, with the biocatalyst placed in the PEGDA phase. The motor is propelled by enzyme‐mediated decomposition of fuel. The speed of the motors is influenced by the roughness of the PEGDA surface after diffusion of dextran and was tuned by using higher molecular weight dextran. This roughness allows for easier pinning of oxygen bubbles and thus higher speeds of the motors. Pinning of bubbles occurs repeatedly at the same location, thereby resulting in constant circular or linear motion.
Ultrasmall Zeolite L Crystals Prepared from Highly Interdispersed Alkali‐Silicate Precursors
Authors: Li Rui , Linares Noemi , Sutjianto James G. , Chawla Aseem , Garcia‐Martinez Javier , Rimer Jeffrey D. 
Published: June 2018

AbstractThe preparation of nanosized zeolites is critical for applications where mass‐transport limitations within microporous networks hinder their performance. Often the ability to generate ultrasmall zeolite crystals is dependent upon the use of expensive organics with limited commercial relevance. Herein, we report the generation of zeolite L crystals with uniform sizes less than 30 nm using a facile, organic‐free method. Time‐resolved analysis of precursor assembly and evolution during nonclassical crystallization highlights key differences among silicon sources. Our findings reveal that a homogenous dispersion of potassium ions throughout silicate precursors leads to the formation of a metastable nonporous phase, which undergoes an intercrystalline transformation to zeolite L. The generation of highly interdispersed alkali‐silicate precursors is seemingly critical to enhancing the rate of nucleation and facilitating the formation of ultrasmall crystal.
Purification of Uranium‐based Endohedral Metallofullerenes (EMFs) by Selective Supramolecular Encapsulation and Release
Authors: Fuertes‐Espinosa Carles , Gómez‐Torres Alejandra , Morales‐Martínez Roser , Rodríguez‐Fortea Antonio , García‐Simón Cristina , Gándara Felipe , Imaz Inhar , Juanhuix Judith , Maspoch Daniel , Poblet Josep M. , Echegoyen Luis , Ribas Xavi 
Published: June 2018

AbstractSupramolecular nanocapsule 1⋅(BArF)8 is able to sequentially and selectively entrap recently discovered U2@C80 and unprecedented Sc2CU@C80, simply by soaking crystals of 1⋅(BArF)8 in a toluene solution of arc‐produced soot. These species, selectively and stepwise absorbed by 1⋅(BArF)8, are easily released, obtaining highly pure fractions of U2@C80 and Sc2CU@C80 in one step. Sc2CU@C80 represents the first example of a mixed metal actinide‐based endohedral metallofullerene (EMF). Remarkably, the host–guest studies revealed that 1⋅(BArF)8 is able to discriminate EMFs with the same carbon cage but with different encapsulated cluster and computational studies provide support for these observations.
Organocatalytic Formation of Chiral Trisubstituted Allenes and Chiral Furan Derivatives
Authors: Poulsen Pernille H. , Li Yang , Lauridsen Vibeke H. , Jørgensen Danny K. B. , Palazzo Teresa A. , Meazza Marta , Jørgensen Karl Anker 
Published: June 2018

AbstractA novel reaction that provides chiral allenes by amino catalytic activation of either aldehydes or α,β‐unsaturated aldehydes for reaction with alkynyl‐substituted enones is presented. The reaction forms a variety of trisubstituted allenes in high yields and with excellent stereoselectivities. The utility of the reaction concept is demonstrated by the synthesis of chiral furan derivatives in high yields and stereoselectivities.
Blood‐Catalyzed RAFT Polymerization
Authors: Reyhani Amin , Nothling Mitchell D. , Ranji‐Burachaloo Hadi , McKenzie Thomas G. , Fu Qiang , Tan Shereen , Bryant Gary , Qiao Greg G. 
Published: June 2018

AbstractThe use of hemoglobin (Hb) contained within red blood cells to drive a controlled radical polymerization via a reversible addition‐fragmentation chain transfer (RAFT) process is reported for the first time. No pre‐treatment of the Hb or cells was required prior to their use as polymerization catalysts, indicating the potential for synthetic engineering in complex biological microenvironments without the need for ex vivo techniques. Owing to the naturally occurring prevalence of the reagents employed in the catalytic system (Hb and hydrogen peroxide), this approach may facilitate the development of new strategies for in vivo cell engineering with synthetic macromolecules.
Thiourea‐Catalyzed Asymmetric Michael Addition of Carbazolones to 2‐Chloroacrylonitrile: Total Synthesis of 5,22‐Dioxokopsane, Kopsinidine C, and Demethoxycarbonylkopsin
Authors: Ni Dongshun , Wei Yi , Ma Dawei 
Published: June 2018

AbstractA modified Takemoto catalyst enabled the asymmetric Michael addition of carbazolones to 2‐chloroacrylonitrile to afford 3,3‐disubstituted carbazolones with excellent enantioselectivity. This method was successfully applied to total syntheses of three Kopsia alkaloids which featured an unprecedented MnIII‐mediated oxidative cyclization to create the caged ring system and a SmI2‐mediated reductive coupling as key steps.
Competition between H and CO for Active Sites Governs Copper‐Mediated Electrosynthesis of Hydrocarbon Fuels
Authors: Schreier Marcel , Yoon Youngmin , Jackson Megan N. , Surendranath Yogesh 
Published: June 2018

AbstractThe dynamics of carbon monoxide on Cu surfaces was investigated during CO reduction, providing insight into the mechanism leading to the formation of hydrogen, methane, and ethylene, the three key products in the electrochemical reduction of CO2. Reaction order experiments were conducted at low temperature in an ethanol medium affording high solubility and surface‐affinity for carbon monoxide. Surprisingly, the methane production rate is suppressed by increasing the pressure of CO, whereas ethylene production remains largely unaffected. The data show that CH4 and H2 production are linked through a common H intermediate and that methane is formed through reactions among adsorbed H and CO, which are in direct competition with each other for surface sites. The data exclude the participation of solution species in rate‐limiting steps, highlighting the importance of increasing surface recombination rates for efficient fuel synthesis.
Oxidative Stability of Papaya Seed Oil From Hainan/Eksotika Obtained by Subcritical and Supercritical Carbon Dioxide Extraction
Authors: Zhang Weimin , Xia Qiuqi , Ji Yanyu , Chen Haiming , Pan Yonggui , Chen Wenxue , Cao Jun , Yang Hong , Huang Wuyang , Wang Liling 
Published: June 2018

AbstractPapaya seed is a good source of edible oil with considerable antioxidant activity. Here, papaya seed oil (PSO) of Hainan/Eksotika variety was obtained by subcritical butane extraction (SBE) and supercritical carbon dioxide extraction (SCDE), and its yields, physicochemical properties, oxidative and thermal stability, and chemical and microscopic structures were compared. The results showed that SBE‐PSO had a higher yield (25.88 ± 0.29% vs. 19.47 ± 0.92%), but a lower melting point compared to SCDE‐PSO. Molecular structures indicated that there was no oxidative degradation during SBE and SCDE. Both SBE and SCDE caused significant structural changes of seed tissues. In addition, aldehyde composition analysis using high performance liquid chromatography (HPLC) showed that SBE‐PSO had fewer octanal, nonanal, 2‐decenal, and 2‐undecenal contents than SCDE‐PSO. All these results proved that SBE‐PSO exhibited superiority on the oxidative stability compared to SCDE‐PSO. It indicated that SBE was a superior method to obtain antioxidant edible oil with good stability.
What happened after the Last Glacial Maximum? Transitions in site use on an arid inland island in north‐western Australia
Authors: REYNEN WENDY , VANNIEUWENHUYSE DORCAS , MORSE KATE , MONKS CARLY , BALME JANE 
Published: June 2018

ABSTRACTThe presence of Aboriginal people in interior refuges as climate conditions deteriorated with the onset of glacial aridity is now well documented in the Australian arid zone. Further excavation at Yurlu Kankala, a large rock shelter located on an island of high land in the inland Pilbara, demonstrates repeated human occupation from at least 47–43 cal ka BP through the Last Glacial Maximum to the mid‐Holocene. Despite the continued presence of bone representing human food remains and an increased occurrence of hearths, after 18–17 cal ka BP there is a dramatic reduction in stone artefact numbers, suggesting that use of the site changed markedly. In exploring the drivers behind this change, we investigate the role of rock shelters in Aboriginal land‐use systems in the Pleistocene Pilbara. Yurlu Kankala makes a substantive contribution to answering questions on changing rock shelter and landscape use during the post‐LGM movement of people into the wider Pilbara uplands.
Hybridized Polyoxometalate‐Based Metal–Organic Framework with Ketjenblack for the Nonenzymatic Detection of H2O2
Authors: Wang Cong , Zhou Ming , Ma Yuanyuan , Tan Huaqiao , Wang Yonghui , Li Yangguang 
Published: June 2018

AbstractThe rational design and development of efficient and affordable enzyme‐free electrocatalysts for electrochemical detection are of great significance for the large‐scale applications of sensor materials, and have aroused increasing research interest. Herein, we report that a typical polyoxometalate (POM)‐based metal–organic framework (NENU5) that was hybridized with ketjenblack (KB) was a highly efficient electrochemical catalyst that could be used for the highly sensitive nonenzymatic detection of H2O2. The composite catalyst exhibited superb electrochemical detection performance towards H2O2, including a broad linear range from 10–50 mm, a low detection limit of 1.03 μm, and a high sensitivity of 33.77 μA mm−1, as well as excellent selectivity and stability. These excellent electrocatalytic properties should be attributed to the unique redox activity of the POM, the high specific surface area of the metal–organic framework (MOF), the strong conductivity of KB, and the synergistic effects of the multiple components in the composites during the electrolysis of H2O2. This work provides a new pathway for the exploration of nonenzymatic electrochemical sensors.
Neubau Übungshalle für die Staatliche Feuerwehrschule Würzburg
Authors: Stumpf Martin , Reinhardt Achim , Wörner Sven 
Published: June 2018

AbstractAuf dem Gelände der Staatlichen Feuerwehrschule in Würzburg entstand eine neue Halle mit 77 m Länge und einer Breite von 40 m. Auf diesem „Spielplatz für große Jungs und starke Mädchen“ ist es künftig möglich, wetterunabhängig und realitätsnah Feuerwehreinsätze jeder Art zu üben. Innerhalb der 21 m hohen Halle sind vielfältige Übungsszenarien möglich. Im Halleninnenraum sind neben einer vierstöckigen Gebäudezeile, in der verschiedenste Nutzungen vom Mehrfamilienhaus über einen Einkaufsladen bis hin zu einem Labor simuliert werden, noch ein Hochregallager und ein Hochhaus mit acht Stockwerken enthalten. Dieses Hochhaus mit einer Höhe von fast 30 m ragt über das Hallendach hinaus und wird durch eine aufgesetzte Haube vor der Witterung geschützt.
Distributed Strain Sensing in der Geotechnik – Teil 2
Authors: Kindler Arne , Großwig Stephan , Pfeiffer Thomas 
Published: June 2018

AbstractMit der vorliegenden Abhandlung wird der erste Beitrag zum Distributed Strain Sensing in der Geotechnik in der Bautechnik ergänzt. Insbesondere zeigt die Vergangenheit, dass gerade beim planenden Ingenieur eine große Unsicherheit hinsichtlich der Ausschreibung besteht. Damit ist vor allem das „Was“ gemeint. Das Feld der ortsverteilten faseroptischen Sensortechnik ist, wie bereits beschrieben, ein weitgefächertes Gebiet. Die im Folgenden zusammengestellten Ausführungen gelten sowohl für das Distributed Temperature Sensing als auch für das Distributed Strain Sensing. Der zusammengetragene Ausschreibungsumfang basiert auf einer 25‐jährigen Tätigkeit auf dem Gebiet der faseroptischen Messtechnik in der Erdöl‐ und Erdgasindustrie, im Wasserbau und der Geotechnik. Die Ausführungen beziehen sich auf das Distributed Strain Sensing. Das beschriebene System wird kommerziell auf dem Markt vertrieben und unterliegt keiner ausschreibungsrelevanten Beschränkung. Der Beitrag umfasst eine kurze allgemeine Beschreibung der auszuschreibenden Leistungen in Verbindung mit Ausschreibungsbausteinen, welche die gewünschte Leistung derart beschreibt, dass der planende Ingenieur wirklich vergleichbare Angebote erhält. Der Beitrag schützt den Ausschreibenden jedoch nicht vor der eigenen Wertung der angebotenen Leistung hinsichtlich der Eignung und Leistungsfähigkeit des Bieters. Abschließend werden zwei nicht abschließende Wirtschaftlichkeitsbetrachtungen zwischen dem Distributed Sensing und konventionellen Messverfahren dargestellt.
Age differences in moral judgment: Older adults are more deontological than younger adults
Authors: McNair Simon , Okan Yasmina , Hadjichristidis Constantinos , de Bruin Wändi Bruine 
Published: June 2018

AbstractIn 2 studies, an older and a younger age group morally evaluated dilemmas contrasting a deontological judgment (do not harm others) against a utilitarian judgment (do what is best for the majority). Previous research suggests that deontological moral judgments are often underpinned by affective reactions and utilitarian moral judgments by deliberative thinking. Separately, research on the psychology of aging has shown that affect plays a more prominent role in the judgments and decision making of older (vs. younger) adults. Yet age remains a largely overlooked factor in moral judgment research. Here, we therefore investigated whether older adults would make more deontological judgments on the basis of experiencing different affective reactions to moral dilemmas as compared with younger adults. Results from 2 experiments indicated that older adults made significantly more deontological moral judgments. Mediation analyses revealed that the relationship between age and making more deontological moral judgments is partly explained by older adults exhibiting significantly more negative affective reactions and having more morally idealistic beliefs as compared with younger adults.
BRCA1 and BRCA2 gene variants and nonsyndromic cleft lip/palate
Authors: Rodriguez Nicholas , Maili Lorena , Chiquet Brett T. , Blanton Susan H. , Hecht Jacqueline T. , Letra Ariadne 
Published: June 2018

BackgroundNonsyndromic cleft lip with or without cleft palate (NSCL/P) is a debilitating condition that not only affects the individual, but the entire family. The purpose of this study was to investigate the association of BRCA1 and BRCA2 genes with NSCL/P.MethodsTwelve polymorphisms in/nearby BRCA1 and BRCA2 were genotyped using Taqman chemistry. Our data set consisted of 3,473 individuals including 2,191 nonHispanic white (NHW) individuals (from 151 multiplex and 348 simplex families) and 1,282 Hispanic individuals (from 92 multiplex and 216 simplex families). Data analysis was performed using Family‐Based Association Test (FBAT), stratified by ethnicity and family history of NSCL/P.ResultsNominal associations were found between NSCL/P and BRCA1 in Hispanics and BRCA2 in NHW and Hispanics (p < .05). Significant haplotype associations were found between NSCL/P and both BRCA1 and BRCA2 (p ≤ .004).ConclusionsOur results suggest a modest association between BRCA1 and BRCA2 and NSCL/P. Further studies in additional populations and functional studies are needed to elucidate the role of these genes in developmental processes and signaling pathways contributing to NSCL/P.
Direct comparison of LC–MS/MS and RIA methods for the pharmacokinetics assessment of human insulin in preclinical development
Authors: Dong Shiqi , Gu Yuan , Wei Guangli , Si Duanyun , Liu Changxiao 
Published: June 2018

AbstractInsulin is an effective therapeutic for diabetes, and the level of insulin in vivo is directly related to the health of diabetic patients. Traditionally, the concentrations of insulin in vivo are determined by the radioimmunoassay (RIA) method. In this study, we developed an LC–MS/MS method for the quantification of human insulin in dog plasma and directly compared the RIA and LC–MS/MS methods. Our LC–MS/MS method exhibited superior accuracy, efficiency and cost‐effective for the pharmacokinetic (PK) assessment of human insulin. The LC–MS/MS method can quantitate human insulin and canine insulin simultaneously without cross‐reactivity, making the analysis more efficient. The LLOQ of our LC–MS/MS method was 38.5 pg/mL, which was necessary to fully describe the PK profiles of endogenous and exogenous insulin in vivo. The direct comparison of PK data obtained from the two methods demonstrated that LC–MS/MS could be an alternative to the RIA method and should be widely used for the quantification of insulin drugs, especially in preclinical studies.