bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainability in construction and built environment: a “wicked problem”?
Authors: Goel Ashish 
Published: February 2019

PurposeThe purpose of this paper is to examine various uncertainties underlying the concept of sustainability in construction and built environment (SCBE) and determine if SCBE is a “wicked problem” (WP).Design/methodology/approachQualitative text analysis and inductive reasoning are used as research methods in this paper. Text analysis of extant literature is performed to categorise the uncertainties underlying the concept of SCBE. Inductive reasoning, based on these categories of uncertainties and the characteristics of WPs provided in the seminal work of Rittel and Webber (1973), is used to assess SCBE as a probable WP.FindingsSix distinct categories of uncertainties underlying the concept of SCBE are developed: temporal uncertainty, spatial uncertainty, stakeholder uncertainty, societal uncertainty, dimensional uncertainty and assessment uncertainty. The inductive reasoning provides a prima facie evidence that SCBE, underpinned by these uncertainties, is a WP.Originality/valueTo the best of author’s knowledge, this is first of its kind analysis that assesses SCBE from a WP perspective by a systematic categorisation of underlying uncertainties. The findings necessitate a new approach for the context-specific conception of sustainability to commensurate with local values. They also provide a sound academic base to challenge the positivist notions generally associated with SCBE, reflected in sustainability assessment and rating systems currently pursued globally as a means of promoting SCBE.
Developers’ willingness to invest in green features in Abuja, Nigeria
Authors: Oyewole Matthew Oluwole , Ojutalayo Adeola Adisa , Araloyin Funmilayo Moyinola 
Published: February 2019

PurposeThe purpose of this paper is to investigate the degree of willingness of property developers to invest in green features in Abuja, the federal capital city of Nigeria, to determine the level of their preparedness for green building development.Design/methodology/approachData were elicited from the property managers of the various property development companies through self-administered questionnaire and analyzed with the use of frequency distribution, percentages and measures of developers’ willingness to invest index.FindingsThe study showed that the developers’ level of willingness to invest in green features is above average with the value of willingness indices on most features rising above 2.5 on a five-point scale. Features that are less capital intensive such as “Location of air intake that are far from source of pollution” (RWI = 4.14) and “Building design that utilize natural and cross ventilation” (RWI = 4.12) attracted higher developers’ level of willingness than features such as “Mechanical ventilation of enclosed parking area” (RWI = 2.15) and “Design for energy efficient deconstruction and recycling” (RWI = 1.84) that are more capital intensive. In addition, the index of willingness (relative willingness index of developers) on features that are associated with occupants’ comfort is higher than the index of willingness on features that confer more of environmental benefits.Practical implicationsThe study concludes by advocating that parliamentary arms of all tiers of government should formulate environmental policies and laws that will entrench sustainable practices in the building industry in the country.Originality/valueThis is one of the few studies on the willingness of major stakeholders to invest in green features, particularly in the Nigerian context.
The impact of perceived price justice and satisfaction on loyalty: the mediating effect of revisit intention
Authors: Cakici A. Celil , Akgunduz Yilmaz , Yildirim Oya 
Published: February 2019

PurposeThe purpose of this study was to examine the relationships between perceived price justice, satisfaction, revisit intention and loyalty among restaurant customers, specially the mediating effect of revisit intention in the relationship between perceived price justice, satisfaction and loyalty.Design/methodology/approachData were collected from a questionnaire distributed to customer of restaurants in Turkey. A total of 304 restaurant customers participated.FindingsResults from structural equation modeling show that price justice and satisfaction positively influence their revisit intention of restaurant customers, also revisit intention positively influences loyalty of restaurant customers. Also, the empirical results indicate that while revisit intention fully mediates the effect of price justice and loyalty, it partially mediates the effect of satisfaction and loyalty.Originality/valueWhen the studies in the literature are examined, it is seen that there are various studies that deal with perceived price justice, customer satisfaction, revisit intention and loyalty variables from a different viewpoint. However, no study has been found on restaurants that investigate the relationship between these four variables and the mediating role of revisit intention. Furthermore, the authors’ study contributes to the hospitality and service management literature in two ways. First, the authors follow recent calls for studies on antecedents of revisit intention, with the aim of providing empirical support to uncover factor that shape customers’ revisit intentions. Second, the authors investigate the attitudinal mechanism that explains how customers’ perception of price justice and satisfaction in their loyalty by exploring the mediation effect of revisit intention. On the other hand, it is foreseen that the study will shed light on restaurant managers and provide healthy data for strategic planning. Additionally, that the results obtained are the practical purpose of the study is to contribute to the determination of product development and promotional strategies for restaurant managements.
Connectivity constrained segmentation of geologic features
Authors: Liu Zhining , Song Chengyun , She Bin , Yao Xingmiao , Hu Guangmin 
Published: February 2019

ABSTRACTSegmentation of geologic features plays a significant role in seismic interpretation. Based on the segmentation results, interpreters can readily recognize the shape and distribution of geologic features in three‐dimensional space and conduct further quantitative analysis. Usually, there are mainly two steps for the segmentation of geologic features: the first step is to extract seismic attributes that can highlight the occurrence of geologic features, and the second step is to apply the segmentation algorithm on the seismic attribute volumes. However, the occurrence of geologic features is not always corresponding to the anomaly value on the seismic attribute volumes and vice versa because of several factors, such as noise in the seismic data, the limited resolution of seismic images and the limited effectiveness of the seismic attribute. Therefore, the segmentation results, which are generated solely based on seismic attributes, are not sufficient to give an accurate depiction of geologic features. Aiming at this problem, we introduce the connectivity constraint into the process of segmentation based the assumption that for one single geologic feature all of its components should be connected to each other. Benefiting from this global constraint, the segmentation results can precisely exclude the interference by false negatives on seismic attribute volumes. However, directly introducing the connectivity constraint into segmentation would face the risk that the segmentation results would deteriorate significantly because of false positives with relatively large area when the connectivity constraints are enforced. Therefore, based on the seismic attribute that highlights the boundary of geologic feature, we further propose a post‐processing technique, calledpruning, to refine the segmentation results. By taking the segmentation of the channel as an example, we demonstrate that the proposed method is able to preserve the connectivity in the process of segmentation and generate better segmentation results on the field data.
A novel approach to investigate hypoxic microenvironment during rice colonization by Magnaporthe oryzae
Authors: Chung Hyunjung , Kim Seongbeom , Kim Ki‐Tae , Hwang Bae‐Geun , Kim Hye‐Jeong , Lee Sang‐Joon , Lee Yong‐Hwan 
Published: February 2019

SummaryBecause molecular oxygen functions as the final acceptor of electrons during aerobic respiration and a substrate for diverse enzymatic reactions, eukaryotes employ various mechanisms to maintain cellular homeostasis under varying oxygen concentration. Human fungal pathogens change the expression of genes involved in virulence and oxygen‐required metabolisms such as ergosterol (ERG) synthesis when they encounter oxygen limitation (hypoxia) during infection. The oxygen level in plant tissues also fluctuates, potentially creating hypoxic stress to pathogens during infection. However, little is known about how in planta oxygen dynamics impact pathogenesis. In this study, we investigated oxygen dynamics in rice during infection by Magnaporthe oryzae via two approaches. First, rice leaves infected by M. oryzae were noninvasively probed using a microscopic oxygen sensor. Second, an immunofluorescence assay based on a chemical probe, pimonidazole, was used. Both methods showed that oxygen concentration in rice decreased after fungal penetration. We also functionally characterized five hypoxia‐responsive genes participating in ERG biosynthesis for their role in pathogenesis. Resulting insights and tools will help study the nature of in planta oxygen dynamics in other pathosystems.
Integrated mobile genetic elements in Thaumarchaeota
Authors: Krupovic Mart , Makarova Kira S. , Wolf Yuri I. , Medvedeva Sofia , Prangishvili David , Forterre Patrick , Koonin Eugene V. 
Published: February 2019

SummaryTo explore the diversity of mobile genetic elements (MGE) associated with archaea of the phylum Thaumarchaeota, we exploited the property of most MGE to integrate into the genomes of their hosts. Integrated MGE (iMGE) were identified in 20 thaumarchaeal genomes amounting to 2 Mbp of mobile thaumarchaeal DNA. These iMGE group into five major classes: (i) proviruses, (ii) casposons, (iii) insertion sequence‐like transposons, (iv) integrative‐conjugative elements and (v) cryptic integrated elements. The majority of the iMGE belong to the latter category and might represent novel families of viruses or plasmids. The identified proviruses are related to tailed viruses of the order Caudovirales and to tailless icosahedral viruses with the double jelly‐roll capsid proteins. The thaumarchaeal iMGE are all connected within a gene sharing network, highlighting pervasive gene exchange between MGE occupying the same ecological niche. The thaumarchaeal mobilome carries multiple auxiliary metabolic genes, including multicopper oxidases and ammonia monooxygenase subunit C (AmoC), and stress response genes, such as those for universal stress response proteins (UspA). Thus, iMGE might make important contributions to the fitness and adaptation of their hosts. We identified several iMGE carrying type I‐B CRISPR‐Cas systems and spacers matching other thaumarchaeal iMGE, suggesting antagonistic interactions between coexisting MGE and symbiotic relationships with the ir archaeal hosts.
Metabolite Profiles of Raw Peanut Seeds Reveal Differences between Market‐Types
Authors: Klevorn Claire M. , Dean Lisa L. , Johanningsmeier Suzanne D. 
Published: February 2019

AbstractPeanuts (Arachis hypogaea L.) are prized for their flavor and popular worldwide as food or as food ingredients. The raw peanut seed contains the precursor compounds to roasted peanut flavor and has the potential to be manipulated through traditional breeding methods. However, little is known about the metabolome of the raw seeds. Comprehensive metabolite profiles of both raw runner and Virginia‐type peanuts were determined. Using a system incorporating several methodologies including (RP)/UPLC‐MS/MS and HILIC/UPLC‐MS/MS, along with quantitation of fatty acids, free amino acids, and tocopherols, 365 metabolites were identified and of these, 52 were significantly different between market types (P < 0.05). Higher levels of gamma‐glutamylalanine, oxylipins, purine metabolites, and alpha‐ketoglutarate derived members of the glutamate family of amino acids defined the Virginia‐type, while runner‐type peanuts were differentiated by their ethylmalonate and eicosenoate content. This study presents a comprehensive analysis of the raw peanut seed, providing knowledge of the range of small molecules present in peanuts. The new information presented here will enable future research for peanut quality improvement.Practical ApplicationPeanuts are widely used as snack foods and as food ingredients. Knowledge of the secondary metabolite compounds in raw peanuts is needed to determine their importance in peanut flavor and nutritional quality. This report used a nontargeted analytical approach for the identification of these types of compounds in peanuts for the first time. These data were supplemented with quantitative analysis of free amino acids and tocopherols and discussed as potential flavor precursors and health promoting compounds.
Polydimethylsiloxane Replicas Efficacy for Simulating Fresh Produce Surfaces and Application in Mechanistic Study of Colloid Retention
Authors: Sun Taozhu , Lazouskaya Volha , Jin Yan 
Published: February 2019

AbstractFoodborne illnesses associated with fresh produce have attracted increasing attention in the food industry, scientific and public health communities. Studies have shown that surface properties of fresh produce can affect bacterial attachment and colonization, yet the mechanisms involved remain poorly understood. In our previous work, using colloids as bacterial surrogates, we demonstrated that colloid retention on fresh produce was controlled by water retention/distribution on produce surfaces, which were in turn governed by produce surface properties. However, high variabilities among the natural samples and multiple factors that were simultaneously involved made it difficult for interpreting the results and in pinpointing the mechanisms responsible for the observed colloid retention behavior. To better evaluate the mechanisms, polydimethylsiloxane (PDMS) replicas of tomato, lettuce, and spinach were fabricated and compared with fresh produce surfaces in this study. The PDMS replicas thoroughly preserved the surface topographical features of their natural counterparts while having identical chemical properties (for example, hydrophobicity), thus, allowing for the separation of surface topography/roughness and hydrophobicity effects. We found that residual water retention/distribution and colloid retention on the PDMS replicas were consistent with the results observed on the corresponding fresh produce surfaces, but had smaller deviations from the respective means when compared to the natural surfaces. The use of PDMS replicas improved experimental reproducibility, and enabled differentiation on the effects of surface hydrophobicity and surface roughness on colloid retention, thus, allowed more rigorous elucidation of the underlying mechanisms. Therefore, PDMS replicas could be used as surrogates of fresh produce for mechanistic studies of surface‐bacteria interactions.Practical ApplicationThis work demonstrates the feasibility of using polydimethylsiloxane (PDMS) to simulate fresh produce surfaces for studying interactions between produce surfaces and colloids, including bacteria. Although it is more realistic to use fruit or vegetable surfaces, the difficulties of working with natural surfaces that are heterogeneous and variable hinder systematic and mechanistic studies. The use of PDMS replicas can eliminate these difficulties and improve experimental reproducibility. This study demonstrated that PDMS replicas could adequately represent the topographical features of natural produce surfaces; the results on colloid retention provided insight into fresh produce contamination and the development of effective decontamination strategies.
Lung cancer family history and exposure to occupational/domestic coal combustion contribute to variations in clinicopathologic features and gene fusion patterns in non‐small cell lung cancer
Authors: Chen Ying , Li Guangjian , Lei Yujie , Yang Kaiyun , Niu Huatao , Zhao Jie , He Rui , Ning Huanqi , Huang Qiubo , Zhou Qinghua , Huang Yunchao 
Published: February 2019

BackgroundBoth genetic and environmental factors contribute to the development of cancer and its mutant spectrum. Lung cancer has familial aggregation. Lung cancer caused by non‐tobacco factors has unique pathological and molecular characteristics. The interaction between genetic lung cancer susceptibility and carcinogens from coal burning remains complex and understudied.MethodsWe selected 410 non‐small cell lung cancer (NSCLC) patients with a family history of lung cancer (FLC) and exposure to coal combustion between 2014 and 2017. Clinicopathologic parameters were analyzed. Reverse transcription‐PCR was performed to detect ALK, ROS1, RET, and NTRK1 rearrangement.ResultsAmong the 410 NSCLC patients, 192 had FLC and 204 (49.8%) were exposed to occupational or domestic coal combustion. FLC patients had the same characteristics regardless of gender and coal exposure: younger age, high female ratio, adenocarcinoma, increased metastasis, later stage at diagnosis, and higher frequency of gene fusion. Sixty‐seven patients (16.3%) had gene rearrangement: 51 (12.4%) harbored EML4‐ALK fusions and 16 ROS1 fusions (3.9%). The highest gene fusion rate (35.1%, 33/94) occurred in patients with both FLC and high tobacco and coal exposure. ALK fusions and total gene rearrangement were closely associated with women, never smokers, younger age, FLC, and coal exposure.ConclusionFLC and exposure to coal combustion have an important impact on the clinicopathological characteristics and gene fusion mode of NSCLC, particularly in cases of higher levels of carcinogens, and genetic susceptibility has a greater impact. Our findings may help evaluate the effect of FLC and coal exposure on the pathogenesis of lung cancer.
The angiotensin‐(1‐7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation
Authors: Romero Alejandra , San Hipólito‐Luengo Álvaro , Villalobos Laura A. , Vallejo Susana , Valencia Inés , Michalska Patrycja , Pajuelo‐Lozano Natalia , Sánchez‐Pérez Isabel , León Rafael , Bartha José Luis , Sanz María Jesús , Erusalimsky Jorge D. , Sánchez‐Ferrer Carlos F. , Romacho Tania , Peiró Concepción 
Published: February 2019

AbstractEndothelial cell senescence is a hallmark of vascular aging that predisposes to vascular disease. We aimed to explore the capacity of the renin–angiotensin system (RAS) heptapeptide angiotensin (Ang)‐(1‐7) to counteract human endothelial cell senescence and to identify intracellular pathways mediating its potential protective action. In human umbilical vein endothelial cell (HUVEC) cultures, Ang II promoted cell senescence, as revealed by the enhancement in senescence‐associated galactosidase (SA‐β‐gal+) positive staining, total and telomeric DNA damage, adhesion molecule expression, and human mononuclear adhesion to HUVEC monolayers. By activating the G protein‐coupled receptor Mas, Ang‐(1‐7) inhibited the pro‐senescence action of Ang II, but also of a non‐RAS stressor such as the cytokine IL‐1β. Moreover, Ang‐(1‐7) enhanced endothelial klotho levels, while klotho silencing resulted in the loss of the anti‐senescence action of the heptapeptide. Indeed, both Ang‐(1‐7) and recombinant klotho activated the cytoprotective Nrf2/heme oxygenase‐1 (HO‐1) pathway. The HO‐1 inhibitor tin protoporphyrin IX prevented the anti‐senescence action evoked by Ang‐(1‐7) or recombinant klotho. Overall, the present study identifies Ang‐(1‐7) as an anti‐senescence peptide displaying its protective action beyond the RAS by consecutively activating klotho and Nrf2/HO‐1. Ang‐(1‐7) mimetic drugs may thus prove useful to prevent endothelial cell senescence and its related vascular complications.
Should antenatal corticosteroids be considered in women with gestational diabetes before planned late gestation caesarean section
Authors: Paul Ryan , Murugesh Carissa , Chepulis Lynne , Tamatea Jade , Wolmarans Louise 
Published: February 2019

Babies born to mothers with gestational diabetes mellitus (GDM) are at a greater risk of developing respiratory complications and hypoglycaemia than those born to mothers without diabetes. However, there is currently insufficient evidence as to whether these risks are altered by antenatal corticosteroids after 37 weeks gestation. This retrospective study suggests that antenatal corticosteroids probably reduce respiratory admissions to the newborn intensive care unit with a mild increase in neonatal hypoglycaemia in women with GDM who deliver via caesarean section after 37 weeks gestation. Consequently, we recommend a randomised, controlled trial is required to determine the efficacy and safety of antenatal corticosteroids specifically in women with GDM.
Survival from cancer in young people: An overview of late effects focusing on reproductive health
Authors: Newton Hannah L. , Friend Amanda J. , Feltbower Richard , Hayden Catherine J. , Picton Helen M. , Glaser Adam W. 
Published: February 2019

AbstractThis paper provides a summary of the areas of survival from childhood, teenage and young adult cancers and the significant late effects that can arise from treatment; with particular focus on the area of reproductive health and the impact on both fertility and pregnancy. To complete this review, Web of Science and MEDLINE were used. Search terms included: “"survival AND childhood OR teenage OR young adult cancer", "late effects", "childhood cancer", "teenage AND/OR young adult cancer", AND "fertility after cancer" OR "pregnancy AND cancer" OR "fertility preservation”. Additionally, the clinical expertise of the authors was drawn upon. Childhood cancer is a thankfully rare occurrence; however, the incidence is increasing. Survival rates remain high and this means that a growing population of childhood and young adult cancer survivors are reaching adulthood. For some of these adults, although cured of their cancer, they are now facing a future with lasting effects on their health from their treatments. These effects, commonly referred to as late effects, are defined as health problems related either directly to the underlying cancer or to its treatment and which occur months or years after treatment has finished. Reproductive health is an important consideration for these patients, and although many will be able to conceive naturally, some will exhibit impaired fertility after their treatments. This can include difficulties at all points along the path from conception to delivery of a live, healthy offspring. High‐quality, large‐population evidence is sparse in many areas relating to fertility risk from treatment and the maternal and fetal health of childhood cancer survivors. Yet given the potential for complications, the authors advocate consideration of fertility at the time of diagnosis and before potentially gonadotoxic treatment.