bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro and in vivo investigation of cardiotoxicity associated with anticancer proteasome inhibitors and their combination with anthracycline
Authors: Pokorna Zuzana , Jirkovsky Eduard , Hlavackova Marketa , Jansova Hana , Jirkovska Anna , Lencova-Popelova Olga , Brazdova Petra , Kubes Jan , Sotakova-Kasparova Dita , Mazurova Yvona , Adamcova Michaela , Vostatkova Lucie , Holzerova Kristyna , Kolar Frantisek , Simunek Tomas , Sterba Martin 
Published: August 2019

Abstract
Although proteasome inhibitors (PIs) are modern targeted anticancer drugs, they have been associated with a certain risk of cardiotoxicity and heart failure (HF). Recently, PIs have been combined with anthracyclines (ANTs) to further boost their anticancer efficacy. However, this raised concerns regarding cardiac safety, which were further supported by several in vitro studies on immature cardiomyocytes. In the present study, we investigated the toxicity of clinically used PIs alone (bortezomib (BTZ), carfilzomib (CFZ)) as well as their combinations with an ANT (daunorubicin (DAU)) in both neonatal and adult ventricular cardiomyocytes (NVCMs and AVCMs) and in a chronic rabbit model of DAU-induced HF. Using NVCMs, we found significant cytotoxicity of both PIs around their maximum plasma concentration (cmax) as well as significant augmentation of DAU cytotoxicity. In AVCMs, BTZ did not induce significant cytotoxicity in therapeutic concentrations, whereas the toxicity of CFZ was significant and more profound. Importantly, neither PI significantly augmented the cardiotoxicity of DAU despite even more profound proteasome-inhibitory activity in AVCMs compared with NVCMs. Furthermore, in young adult rabbits, no significant augmentation of chronic ANT cardiotoxicity was noted with respect to any functional, morphological, biochemical or molecular parameter under study, despite significant inhibition of myocardial proteasome activity. Our experimental data show that combination of PIs with ANTs is not accompanied by an exaggerated risk of cardiotoxicity and HF in young adult animal cardiomyocytes and hearts.
Three-/Four-Dimensional Ultrasound Technology in Speech Research
Authors: Lulich Steven M. , Pearson William G. 
Published: August 2019

Purpose
Speech production is a complex 3-dimensional (3D) process, and yet most of what is known about it is derived from 2D midsagittal data. The relatively recent development of safe 3D imaging technologies (including magnetic resonance imaging and ultrasound) provide new opportunities to revisit and reformulate what is already known and to push the boundaries of current knowledge still further. A particularly useful imaging modality for this purpose is 3D/4D ultrasound, which until very recently was not well suited for studies in speech research. This technical report presents an overview of what 3D/4D ultrasound can contribute to speech research, with a focus on 2 demonstrations.

Conclusion
The 1st demonstration illustrates how 3D/4D ultrasound makes it possible to image certain vocal tract anatomical structures and planes that conventional 2D ultrasound is not capable of imaging. The 2nd demonstration illustrates how 3D/4D ultrasound can be combined with static 3D magnetic resonance imaging to provide new insight into the temporal pervasiveness and spatial extensiveness of lateral contact between the tongue and palate–teeth during speech production.
Broadband spectroscopy of astrophysical ice analogues
Authors: Giuliano B. M. , Gavdush A. A. , Müller B. , Zaytsev K. I. , Grassi T. , Ivlev A. V. , Palumbo M. E. , Baratta G. A. , Scirè C. , Komandin G. A. , Yurchenko S. O. , Caselli P. 
Published: August 2019

Context.Reliable, directly measured optical properties of astrophysical ice analogues in the infrared and terahertz (THz) range are missing from the literature. These parameters are of great importance to model the dust continuum radiative transfer in dense and cold regions, where thick ice mantles are present, and are necessary for the interpretation of future observations planned in the far-infrared region.Aims.Coherent THz radiation allows for direct measurement of the complex dielectric function (refractive index) of astrophysically relevant ice species in the THz range.Methods.We recorded the time-domain waveforms and the frequency-domain spectra of reference samples of CO ice, deposited at a temperature of 28.5 K and annealed to 33 K at different thicknesses. We developed a new algorithm to reconstruct the real and imaginary parts of the refractive index from the time-domain THz data.Results.The complex refractive index in the wavelength range 1 mm–150μm (0.3–2.0 THz) was determined for the studied ice samples, and this index was compared with available data found in the literature.Conclusions.The developed algorithm of reconstructing the real and imaginary parts of the refractive index from the time-domain THz data enables us, for the first time, to determine the optical properties of astrophysical ice analogues without using the Kramers–Kronig relations. The obtained data provide a benchmark to interpret the observational data from current ground-based facilities as well as future space telescope missions, and we used these data to estimate the opacities of the dust grains in presence of CO ice mantles.
MUSE library of stellar spectra
Authors: Ivanov Valentin D. , Coccato Lodovico , Neeser Mark J. , Selman Fernando , Pizzella Alessandro , Dalla Bontà Elena , Corsini Enrico M. , Morelli Lorenzo 
Published: August 2019

Context. Empirical stellar spectral libraries have applications in both extragalactic and stellar studies, and they confer an advantage over theoretical libraries because they naturally include all relevant chemical species and physical processes. In recent years we have seen a stream of new sets of high-quality spectra, but increasing the spectral resolution and widening the wavelength coverage means resorting to multi-order echelle spectrographs. Assembling the spectra from many pieces results in lower fidelity of their shapes.
Aims. We aim to offer the community a library of high-signal-to-noise spectra with reliable continuum shapes. Furthermore, the use of an integral field unit (IFU) alleviates the issue of slit losses.
Methods. Our library was built with the MUSE (Multi-Unit Spectroscopic Explorer) IFU instrument. We obtained spectra over nearly the entire visual band (λ ∼ 4800–9300 Å).
Results. We assembled a library of 35 high-quality MUSE spectra for a subset of the stars from the X-shooter Spectral Library. We verified the continuum shape of these spectra with synthetic broadband colors derived from the spectra. We also report some spectral indices from the Lick system, derived from the new observations.
Conclusions. We offer a high-fidelity set of stellar spectra covering the Hertzsprung-Russell diagram. These can be used for both extragalactic and stellar studies and demonstrate that the IFUs are excellent tools for building reliable spectral libraries.
Smart energy management of combined ventilation systems in a nZEB
Authors: Rey-Hernández Javier M. , Lorenzo González Sergio , San José-Alonso Julio F. , Tejero-González Ana , Velasco-Gómez Eloy , Rey-Martínez Francisco J. 
Published: August 2019

The high energy consumption, attached to a high energy demand in buildings, has led the development of several research projects with the target of reducing the energy consumption in the buildings. As a result of this high consumption, the increased CO2 emissions that have been generated in recent years, have reached alarming levels, which is why it is necessary to reduce the environmental impact which we are contributing to our planet through the use of energy.
The European Directive on Building Performance (EPBD 2018/844/EU), recently updated, requires new buildings to be close to the Zero Energy Buildings (nZEBs), increasing the use of renewable energies on-site, and also highlight how to get to improve the cost-effective renovation of existing buildings with the introduction of building control and automation systems ( smart systems), as well as the energy savings and increase the efficiency of energy systems, by reducing CO2 emissions. The use of new renewable energy technologies integrated in buildings, with the aim of reducing the consumption of the facilities that all nZEB buildings must have, such as the ventilation system used as an Indoor Air Quality (IAQ) control technique.
In this study, the energy management of the enthalpy ventilation control system is analysed, where dynamic monitoring is going on in the building controlled through Supervisory Control And Data Acquisition (SCADA), in combination with different ventilation systems as free-cooling, heat recovery and geothermal energy of an Earth Air Heat eXchanger (EAHX), all of them as strategies implemented in a real nZEB building (LUCIA) located on the campus at the University of Valladolid, with the goal of improving energy efficiency in ventilation. In order to get this aims, monitoring data of several energy parameters (temperature, air velocity, air flow rate, enthalpy, etc.) are measurements, they allow us to perform a control of the combined ventilation systems to achieve a high IAQ and analyze an optimization of the energy efficiency of the all systems and to study of energy recovery and savings of carbon emissions that directly affect the reduction of the impact of climate change.
The results achieved are the energy efficiency of the building in ventilation and optimum system operation in cooling and heating mode. In addition, by controlling the ventilation, the IAQ of the nZEB building is improved.
Design methodology for combined production and distribution for domestic hot water and space heating
Authors: Verhaert Ivan 
Published: August 2019

As local heat demand is reducing due to an increased insulation rate, investing in sustainable heat production becomes less interesting. Nevertheless a substantial demand of heat remains in which the thermal energy needed for the generation of domestic hot water grows relatively in importance. In the last two years standards to size production and distribution systems were revised and methods based on tap patterns were elaborated. Nevertheless, some aspects were not covered yet, e.g. how to deal with decentralized storage and how to use these results and new insights in combined heating systems, taking into account that modifications in standards for both space heating and domestic hot water installations are reducing the oversizing. In this paper, first some critical points of attention due to this evolution are illustrated with a case example. Next it is shown how different rules of thumb often developed by different manufacturers deal with these aspects, but lacking however compatibility with existing standards and/or new insights.
Finally, a methodology is proposed and illustrated how to size distribution and production systems for combined heating systems taking into account central and decentralized storage and different kind of end users. The method can be used to size heating systems in collective housing or in district heating networks.
Moisture Recovery – A Dynamic Modelling Approach
Authors: Kremer Martin , Mathis Paul , Müller Dirk 
Published: August 2019

With rising insulation standards, the use of mechanical ventilation, especially in non-residential buildings, is becoming increasingly relevant. To ensure thermal comfort and avoid health problems for people in the room, cost- and energy-intensive humidification of the supply air is necessary. The use of moisture recovery systems can thus significantly reduce the energy consumption of ventilation systems. Despite this energy-saving potential, moisture recovery systems are rarely used in ventilation systems.
To forecast the efficiency of moisture recovery systems in partial load operation and under different climatic conditions, a dynamic model of a membrane-based enthalpy exchanger was developed in the object-oriented modelling language Modelica. The model is based on the solution diffusion model, a quite common approach. In contrast to the models found in the literature, the sorption process is not assumed to be in equilibrium state. Rather, as a first approach the membrane’s permeance, consisting of the solubility and diffusion coefficient, is modelled with a linear dependency on the moisture difference between the two incoming airflows.
A parameter fitting has been carried out with experimental data to determine the unknown material parameters. The model containing the fitted parameter set was validated using different experimental data.
The Influence on Daylight and Energy Consumption of Expanded Metal Mesh Applied on Building Façades
Authors: Yaw-Shyan TSAY , Chih-Hung YANG 
Published: August 2019

Expanded metal mesh has become widely used as a shading element in the façade of many buildings in recent years, and its energy saving performance has been evaluated in tropical/subtropical countries. However, expanded metal mesh reduces solar radiation while also reducing the natural daylight entering the building. This study’s objective is to assess the impact of expanded metal mesh on building energy consumption and natural daylighting.
The daylight effects on visual comfort and energy consumption of an office building located in Tainan, Taiwan were studied via building simulation program DIVA. Parameters including window to wall ratios (WWR), perforation rate expanded metal mesh, and glazing of window glass were studied, and a daylight standard of LEED rating system was used for evaluation.
The results showed that when the office building with large WWR and less glazing, the expanded metal mesh performed a better energy saving effect. For an office building with 50% WWR, the laminated clear glass and expanded metal mesh with 21% perforation rate were suggested to be the best design solution for meeting the LEED daylight standard and the lowest energy consumption.
Annual performance analysis of heat emission in radiator and underfloor heating systems in the European reference room.
Authors: Võsa Karl-Villem , Ferrantelli Andrea , Kurnitski Jarek 
Published: August 2019

In this paper, we investigate the energy usage and emission efficiency of radiator and underfloor heating systems coupled with ON/OFF and PI controls, by performing annual simulations with the IDA ICE software package. Results from measurements carried out in early 2018 at the nZEB test facility near the Tallinn University of Technology are used to calibrate validated emitter and controller models. The calibrated models are then used to assess the energy performance of the systems in a simulation spanning the whole year, using climate data for Strasbourg in the European reference room. The annual simulation is conducted in a specific room with fixed geometry and boundary conditions.
As a novelty value of the present study, we impose a non-standard control strategy based on maintaining a specified operative temperature within the room. A single-valued performance indicator, in the form of an increased air temperature set-point, is accordingly obtained for each emitter configuration to be used in further calculations of hourly, monthly or annual heating energy usage. Such a temperature increment accounts for imperfect control, air stratification within the room and the additional temperature increase that is required for achieving a desired operative temperature.
Towards zero energy hospital buildings: a polyclinic building as case study.
Authors: Dainese Enrico , Walker Shalika , Maassen Wim , Zeiler Wim 
Published: August 2019

The need for (nearly) Zero Energy Buildings (nZEBs) becomes increasingly important due to climate change and increasing energy prices. Considering that, on average the existing hospitals use 3.5 times more energy than the nZEB requirement, reaching zero energy a very challenging task. However, monitoring hospitals’ energy flows together with a holistic view on building functions and occupancy can contribute to achieving potential energy savings, which is lacking in the current hospital buildings.
Therefore, in this study, the energy saving potentials of a polyclinic building of a hospital in the Netherlands was investigated through a holistic inspection of the building and its occupancy. The analysis is performed in order to investigate the building characteristics, energy supply and demand. It was found that the number of people present was considerably lower than the full capacity, with 30% average occupancy in the medical facilities and 70% for the administrative areas. The air supply of the current ventilation system was found to be constant irrespective of the number of people present in these rooms. Furthermore, a discrepancy of 30- 50% was found between designed and installed lighting systems. The analysis of the polyclinic showed possible energy-saving measures with controlled ventilation rates and lighting according to the occupancy.
Risk of Thyroid Disorders in Patients with Gout and Hyperuricemia
Authors: Xu Jian , Wang Bin , Li Qian , Yao Qiuming , Jia Xi , Song Ronghua , Zhang Jin-an 
Published: August 2019

AbstractThe risk of thyroid autoimmunity and thyroid dysfunction among patients with gout and hyperuricemia has not been well defined. This study was undertaken to examine the impact of gout and hyperuricemia on risk of thyroid disorders including thyroid autoimmunity and thyroid dysfunction. A population-based cross-sectional study was conducted to assess the risk of thyroid autoimmunity and thyroid dysfunction related to gout and hyperuricemia, which included 115 gout patients, 439 hyperuricemic patients, and 2 254 individuals without gout and hyperuricemia. A systematic review and meta-analysis of 14 observational studies was also done to systematically evaluate the risk of thyroid dysfunction among patients with gout and hyperuricemia. Findings from the cross-sectional study suggested a significantly increased risk of hypothyroidism among female gout patients (OR=2.44, 95% CI 1.15–5.17, p=0.02). Besides, gout could also substantially increase risk of Hashimoto’s thyroiditis in women (OR=3.15, 95% CI 1.53–6.49, p=0.002). The meta-analysis proved a considerably increased risk of hypothyroidism among both gout patients (OR=1.51, 95% CI 1.23–1.85, p<0.001) and hyperuricemic patients (OR=1.34, 95% CI 1.11–1.61, p=0.002). Moreover, this meta-analysis also suggested that gout could also significantly increase the risk of hyperthyroidism (OR=1.25, 95% CI 1.06–1.48, p=0.01). The findings from the study suggest increasing risk of hypothyroidism and Hashimoto’s thyroiditis among gout patients. Moreover, gout but not hyperuricemia is linked to increased risk of hyperthyroidism. More studies are warranted to elucidate the influence of gout and hyperuricemia on thyroid disorders.
Riesenzellarteriitis: Aktuelle Erkenntnisse zu Epidemiologie, Pathogenese, Diagnostik und Therapie
Authors: Keyßer Gernot 
Published: August 2019

ZusammenfassungAls Riesenzellarteriitis (RZA, englisch giant cell arteritis, GCA) bezeichnet man eine Vaskulitis der großen Gefäße, also der Aorta sowie der aortennahen Gefäße erster und zweiter Ordnung. RZA sind in Manifestation und Verlauf vielgestaltige Erkrankungen, die häufig hohe Ansprüche an die Diagnostik und die langfristige Betreuung der Patienten stellen. Fortschritte in Ultraschall-, MRT- und Positronen-Emissionstomografie haben die Diagnostik erleichtert und den Blick für seltenere und ungewöhnliche Manifestationsformen geschärft, die früher oft unerkannt geblieben sind. Therapie der ersten Wahl sind auch heute noch Corticoide. Deren langfristige und hochdosierte Anwendung ist bei den meist älteren und oft polymorbiden Patienten nicht unproblematisch. MTX stellt eine sinnvolle Möglichkeit zur Corticoid-Einsparung dar. Die Einführung der Therapie mit Interleukin-6-Rezeptor-Antikörpern hat neue therapeutische Möglichkeiten für Patienten eröffnet, bei denen langfristige Steroidgaben gefährlich oder kontraindiziert sind. Hauptziel der Behandlung ist die Vermeidung von Komplikationen wie Erblindung, Gefäßverschlüssen oder Aneurysmata sowie die Verhinderung von Therapiekomplikationen.
Extraintestinale Manifestationen bei chronisch-entzündlichen Darmerkrankungen
Authors: Doßow Lauren , Arnim Ulrike von 
Published: August 2019

ZUSAMMENFASSUNGChronisch-entzündliche Darmerkrankungen (CED) umfassen die Colitis ulcerosa (CU) und den Morbus Crohn (MC) und stellen primär eine gastroenterologische Domäne dar. Neben gastrointestinalen Beschwerden erfahren allerdings bis zu 50 % der Patienten mit einer CED mindestens ein extraintestinales Symptom, was als extraintestinale Manifestation (EIM) bezeichnet wird.Fast jedes Organsystem kann von einer extraintestinalen Manifestation betroffen sein. Die häufigsten extraintestinalen Manifestationen sind muskuloskelettal, gefolgt von Haut- und Augenbeteiligungen. Extraintestinale Manifestationen treten häufiger bei Morbus Crohn als bei Colitis ulcerosa auf. Die Symptome der extraintestinalen Manifestation können zu einer relevanten Einschränkung der Lebensqualität führen. Teilweise besteht eine Assoziation zur Krankheitsaktivität.Chronisch-entzündliche Darmerkrankungen sind als Systemerkrankung zu betrachten. Daher profitieren die Patienten von einem interdisziplinären Diagnose- und Therapiekonzept. Bei extraintestinaler Beschwerdeanamnese bzw. Untersuchungsbefunden muss die extraintestinale Manifestation einer CED in Betracht gezogen werden und eine fachspezifische Mitbehandlung ist zu initiieren.Ein Konsens über die Definition von extraintestinaler Manifestation und die Zuordnung von Krankheiten und Symptomen als extraintestinale Manifestation besteht noch nicht. Wünschenswert wären weitere Bestrebungen für eine exakte Definition.
Erste Ergebnisse: Vitamin-D-Versorgung bei Piloten und Luftfahrtpersonal der Bundeswehr
Authors: Pippig Torsten , Matthias Oertel , Zahedi Farzaneh 
Published: August 2019

ZusammenfassungDie Hauptquelle des Menschen für Vitamin D ist die Eigensynthese in den oberen Hautschichten mithilfe des Sonnenlichts (80–90 %). 10–20 % des Vitamin-D-Bedarfs deckt der Mensch über die Ernährung. Ein 25-OH-Vitamin-D-Wert, das ist die Speicherform des VitD3, im Serum (i. S.) von mindestens 30 ng/ml gilt als Suffizienz, höhere Normwerte werden diskutiert. In dieser Arbeit werden die Vitamin-D-Werte im Serum von 2176 Probanden (lizenzpflichtiges und fliegendes Personal der Bundeswehr) im Untersuchungszeitraum vom 01. Dezember 2017 bis 30. November 2018 ausgewertet. 71,6 % aller Probanden (N = 1557) hatten einen Vitamin-D-Wert unterhalb des empfohlenen Normwerts > 30 ng/ml, 25,8 % (N = 648) der „gesunden“ Probanden hatten einen Vitamin-D-Mangel (< 20 ng/ml). In dieser Studie hatten das Alter, das Geschlecht, der Body Mass Index (BMI), Harnsäure (HSR) und C-reaktives Protein (CRP) sowie Dienst- beziehungsweise Wohnort in Deutschland (Postleitregionen) keinen Bezug zum Vitamin-D-Mangel. Die bekannten jahreszeitlichen beziehungsweise monatlichen Schwankungen, in Abhängigkeit der Sonnenstunden pro Monat, wurden auch in dieser Studie gesehen.
Congenital Hepatic Vascular Anomalies
Authors: Chewning Rush H. 
Published: August 2019

AbstractCongenital hepatic vascular anomalies, following the classification system originally proposed by Mulliken and Glowacki and subsequently developed by the International Society for the Study of Vascular Anomalies, are characterized as either tumors or malformations. The former includes infantile hemangioma, congenital hemangioma, angiosarcoma, and epithelioid hemangioendothelioma. The latter includes arterioportal fistula, portosystemic shunt, arteriovenous malformation, and venous malformation. Despite this well-established system, there still exists confusion in terminology that can lead to delayed diagnosis or improper treatment. Knowledge of the clinical presentation and imaging characteristics of these entities, as well as the nosologic system for vascular anomalies, is essential in arriving at the correct diagnosis, which in turn informs proper treatment.