bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endocrine aryl hydrocarbon receptor signaling is induced by moderate cutaneous exposure to ultraviolet light
Authors: Memari Babak , Nguyen-Yamamoto Loan , Salehi-Tabar Reyhaneh , Zago Michela , Fritz Jorg , Baglole Carolyn J. , Goltzman David , White John H. 
Published: December 2018

AbstractLinks between solar UV exposure and immunity date back to the ancient Greeks with the development of heliotherapy. Skin contains several UV-sensitive chromophores and exposure to sunlight can produce molecules, such as vitamin D3, that act in an endocrine manner. We investigated whether the aryl hydrocarbon receptor (AHR), an environmental sensor and ligand-regulated transcription factor activated by numerous planar compounds of dietary or environmental origin, could be the target of endocrine photoproducts produced by cutaneous UV exposure. 15-to 30-minute exposure of cells to a minimal erythemal dose of UVB irradiationin vitroinduced translocation of the AHR to the nucleus, rapidly inducing site-specific DNA binding and target gene regulation. Importantly,ex vivostudies withAhrwild-type or null fibroblasts showed that serum from mice whose skin was exposed to a 15 min UVB dose, but not control serum, contained agonist activity within 30 min of UV irradiation, inducing AHR-dependent gene expression. Moreover, a 15-min cutaneous UVB exposure induced AHR site-specific DNA binding and target gene regulationin vivowithin 3-6 hr post-irradiation in blood and in peripheral tissues, including intestine. These results show that cutaneous exposure of mice to a single minimal erythemic dose of UVB induces rapid AHR signaling in multiple peripheral organs, providing compelling evidence that moderate sun exposure can exert endocrine control of immunity through the AHR.
Systematic review and meta-analysis of 50 years of coral disease research visualized through the scope of network theory
Authors: Montilla Luis M. , Ascanio Alfredo , Verde Alejandra , Croquer Aldo 
Published: December 2018

AbstractCoral disease research encompasses five decades of undeniable progress. Since the first descriptions of anomalous signs, we have come to understand multiple processes and environmental drivers that interact with coral pathologies. To gain a better insight into the knowledge we already have, we explored how key topics in coral disease research have been related to each other using network analysis. We reviewed 719 papers and conference proceedings published from 1965 to 2017. From each study, four elements determined our network nodes: 1) studied disease(s); 2) host genus; 3) marine ecoregion(s) associated with the study site; and 4) research objectives. Basic properties of this network confirmed that there is a set of specific topics comprising the majority of research. The top five diseases, genera, and ecoregions studied accounted for over 48% of the research effort in all cases. The community structure analysis identified 15 clusters of topics with different degrees of overlap among them. These clusters represent the typical sets of elements that appear together for a given study. Our results show that while some coral diseases have been studied considering multiple aspects, the overall trend is for most diseases to be understood under a limited range of approaches, e.g. bacterial assemblages have been considerably studied in Yellow and Black band diseases while immune response has been better examined for the aspergillosis-Gorgoniasystem. Thus, our challenge in the near future is to identify and resolve potential gaps in order to achieve a more comprehensive progress on coral disease research.
Face-selective units in human ventral temporal cortex reactivate during free recall
Authors: Khuvis Simon , Yeagle Erin M. , Norman Yitzhak , Grossman Shany , Malach Rafael , Mehta Ashesh D. 
Published: December 2018

AbstractProperties of face-responsive individual neurons in the human ventral temporal cortex (VTC) have yet to be studied, and their role in conscious perception remains unknown. To explore this, we implanted microelectrodes into the VTCs of eight human subjects undergoing invasive epilepsy monitoring. Most (26 of 33) category-selective units showed specificity for face stimuli, with a range of response profiles. Different face exemplars evoked consistent and discriminable responses in the population of units sampled. During a free recall task, face-selective units selectively reactivated in the absence of visual stimulation during the 2-second window prior to face recall events. Furthermore, the identity of the recalled face could be predicted by comparing activity preceding recall events to activity evoked by visual stimulation.
High-throughput microfluidic characterization of erythrocyte shape and mechanical variability
Authors: Reichel Felix , Mauer Johannes , Nawaz Ahmad Ahsan , Gompper Gerhard , Guck Jochen , Fedosov Dmitry A. 
Published: December 2018

The motion of red blood cells (RBCs) in microchannels is important for microvascular blood flow and biomedical applications such as blood analysis in microfluidics. The current understanding of the complexity of RBC shapes and dynamics in microchannels is mainly based on several simulation studies, but there are a few systematic experimental investigations. Here, we present a combined study, which systematically characterizes RBC behavior for a wide range of flow rates and channel sizes. Even though simulations and experiments generally show good agreement, experimental observations demonstrate that there is no single well-defined RBC state for fixed flow conditions, but rather a broad distribution of states. This result can be attributed to the inherent variability in RBC mechanical properties, which is confirmed by a model that takes the variation in RBC shear elasticity into account. This represents a significant step toward a quantitative connection between RBC behavior in microfluidic devices and their mechanical properties, which is essential for a high-throughput characterization of diseased cells.Significance StatementThe ability to change shape is crucial for the proper functioning of red blood cells under harsh conditions in the microvasculature, since their shapes strongly affect the flow behavior of whole blood. Our results from simulations and systematic experiments reveal the shapes and dynamics of red blood cells for different flow conditions and channel dimensions, generally in good agreement. However, in the experiments, cells do not exhibit a single well-defined shape for fixed flow conditions. We show that this distribution of shapes can be attributed to the variability in mechanical properties of red blood cells.
Effects of long-lasting insecticide net (LLINs) ownership/utilisation indicators on annual household malaria episodes (AHMEs) in three Health Districts in Cameroon
Authors: Cho Frederick Nchang , Fru Paulette Ngum , Cho Blessing Menyi , Munguh Solange Fri , Jokwi Patrick Kofon , Ngah Yayah Emerencia , Fru Celestina Neh , Tassang Andrew N , Ekobo Albert Same 
Published: December 2018

ABSTRACTIntroductionHousehold residents in malaria endemic areas are at high risk of multiple malaria episodes per year. This study investigated the annual household malaria episodes (AHMEs) in three health districts in Cameroon.MethodsA community-based cross-sectional household survey using a multi-stage cluster design was conducted 2 – 3 years post campaign to assess long-lasting insecticide net (LLINs) ownership, utilisation, and maintenance as well as demographic characteristics. Multinomial regression analysis was used to identify factors associated with household LLIN ownership, utilization, and AHME.ResultsHousehold LLINs ownership, de-facto population with universal utilisation, and AHME were respectively, 92.5%, 16.0%, and 83.4%; thus, 4 out of 25 household residents effectively used LLINs the previous night. AHME was significantly (p < 0.05) associated with age and gender (OR; 1.6, 95% C.I; 1.1 – 2.3) of household head, health district (OR; 2.8, 95% C.I; 1.1 – 7.2) and tiredness (OR; 2.6, 95% C.I; 1.0 – 6.3). LLINs ownership and insufficiency also significantly contributed to AHME. The overall average cost for the treatment of malaria was 6,399.4±4,892.8Fcfa (11.1±8.5US$).ConclusionsThe proportion of households with at least one LLIN and those with at least one AHME were high. Findings are of concern given that average cost for the treatment of malaria represents a potentially high economic burden. The results outlined in this paper provide an important tool for the examination of the deficiencies in LLINs regular and universal utilisation.
Responding to FASD: what social and community service professionals do in the absence of diagnostic services and practice standards
Authors: Bagley Kerryn 
Published: December 2018

Purpose
The purpose of this paper is to ascertain the experiences and practices of social and community service professionals working with Fetal Alcohol Spectrum Disorder (FASD) or suspected FASD in New Zealand.

Design/methodology/approach
The research examined professionals’ empirical experience of working with FASD or suspected FASD. In total, 21 participants working in practice settings relevant to dual diagnosis were interviewed, with each interview being of 1–2 h duration. The interview data were transcribed and coded using the constant-comparative method in order to derive themes.

Findings
Participants identified a number of barriers to understanding or working with FASD: the limited knowledge of FASD and the absence of FASD from training contexts, difficulty obtaining institutional support and the challenge of working without a diagnosis. Participants also articulated a range of strategies for approaching FASD within the identified barriers of their practice contexts, specifically: working with alternative diagnoses, focussing on adjusting expectations, adopting a strengths-based approach, actively advocating for clients when working with other sectors and systems and focussing on prevention education.

Originality/value
This research expands the knowledge base for social and community service practice in contexts where FASD maybe a factor contributing to poor health and well-being outcomes for clients. It clarifies the challenges that professionals face when encountering FASD or suspected FASD in their work, reveals key gaps in individual and systemic knowledge about FASD and provides new insight into what professionals do to address these challenges. It also adds to the body of research concerning FASD in the Australasian context more broadly.
Exploring behavioural factors for information sharing in BIM projects in the Malaysian construction industry
Authors: Che Ibrahim Che Khairil Izam , Mohamad Sabri Norsabrina Aine , Belayutham Sheila , Mahamadu Abdul 
Published: December 2018

Purpose
Despite the wave of enthusiasm for building information modelling (BIM) as a platform for information sharing, issues from the context of information-sharing behaviours still exist. The purpose of this paper is to explore the behavioural factors for successful information sharing in BIM projects in Malaysia.

Design/methodology/approach
Based on a literature review, a questionnaire was designed containing seven identified behavioural factors and their sub-elements. Data were collected through a questionnaire survey with 42 experienced BIM practitioners. In addition to that qualitative semi-structured interviews were conducted with nine construction practitioners in the Malaysian construction industry. Initially, a descriptive statistical analysis was adopted, followed by multivariate analysis that was employed to examine the possible effect of demographic attributes (i.e. nature of organisation and work experience in BIM) on the behavioural factors.

Findings
The analytical results indicated that communication, accountability and trust were the top three behavioural factors influencing successful information sharing. Additionally, the majority of the behavioural factors on information sharing were found to be not significantly dependent on both, the nature of organisations and the level of BIM experiences. Overall, the success of information sharing in the digital environment (i.e. BIM) depends on organisational behaviour supported by the collaborative constructs.

Research limitations/implications
Due to the fact that BIM implementation in Malaysia is still in its infancy, this study was limited to local context with small-scale BIM practitioners. Therefore, their views may not represent all BIM-related stakeholders in the industry.

Practical implications
The success of information sharing in BIM projects is a result of a combination of various factors, and this study provides construction practitioners with information on the behavioural factors, which could assist them in creating collective and collaborative information sharing in a digital environment.

Originality/value
Despite the fact that this study is country specific, the paper presents a new perspective on the behavioural context of information sharing in BIM projects. The findings further extend the current BIM literature by providing an insight into what it takes for project teams to reinforce their information sharing in the Malaysian digital environment through improvements in behaviours.
Numerical study on crack propagation in linear elastic multiphase composite materials using phase field method
Authors: Li Xiang , Chu Dongyang , Gao Yue , Liu Zhanli 
Published: December 2018

PurposeThe purpose of this paper is to develop an efficient numerical method to study the complex crack initiation and propagation in linear elastic multiphase composites.Design/methodology/approachA phase field method is developed to study the complex fracture behavior in multiphase composites. A damage threshold is introduced for referring crack initiation in the proposed method. The damage threshold is assigned as a material property so that different composite components possess different thresholds. In this manner, smooth transition from crack initiation to propagation is revealed.FindingsThe proposed method is used to investigate complex crack evolution in mesoscale cementitious composite, which consists of aggregates, matrix and void pores. From a mesoscale point of view, it is found that cracks prefer to evolve within the matrix phase. As a crack encounters an aggregate, it tends to bypass the aggregate and evolve along the interface. Cracks tend to avoid to penetrate through aggregates. Also, cracks tend to be attracted by void pores. From a mesoscale point of view, it is revealed that the elastic modulus and strength of concrete models are closely related to porosity.Originality/valueA criterion with a damage threshold is introduced to the proposed method. The criterions with and without a damage threshold are compared with each other in details. The proposed method is proven to be a useful tool to study mechanical behavior and crack evolution of brittle multiphase composites.
A scientometric analysis of BIM studies in facilities management
Authors: Hilal Mustafa , Maqsood Tayyab , Abdekhodaee Amir 
Published: December 2018

Purpose
The purpose of this paper is to statistically classify and categorize Building Information Modelling (BIM)-Facility Management (FM) publications in order to extract useful information related to the adoption and use of BIM in FM.

Design/methodology/approach
This study employs a quantitative approach using science mapping techniques to examine BIM-FM publications using Web of Science (WOS) database for the period between 2000 and April 2018.

Findings
The findings guide the researchers who are interested in the BIM-FM model by providing visual maps analysis of that area in a simple, easy and readable way. In addition, they help the researchers to understand which authors and journals to consider when dealing with BIM-FM topics. Finally, knowledge gaps in this domain can be identified easily using the findings of the Scientometric analysis.

Research limitations/implications
First, the results of the analysis depend on the database that has been extracted from WOS, and therefore it carries any of WOS’s limitations in terms of how much it covers the published studies. Another limitation is that the study is based on exploration of “what” questions, rather than “how” and “why”. These limitations represent the hot topics to be addressed in future research.

Originality/value
This research is the first to conduct the Scientometric Analysis of BIM-FM topics, in which 68 top-ranked publications were systematically examined using a Science Mapping method through VOSviewer software.
Cross-cultural application of a practice-oriented acquiescence measure
Authors: Krautz Carolin , Hoffmann Stefan 
Published: December 2018

PurposeExtant research shows that acquiescence response style (ARS) is culture-bound and may bias the results of comparative cross-cultural studies. Conventional measures of ARS are difficult to apply in practice. To overcome this limitation, the purpose of this paper is to propose an alternative, practice-oriented measure, namely, pARS. The authors apply Hofstede’s cultural dimensions (Hofstedeet al., 2010) to test whether pARS is culture-bound. The cross-cultural study provides a high level of cross-cultural generalisability due to the extensive number of surveyed countries (n=30) and subjects (n=236.089). The authors run multi-level analysis to identify within- and between-country-level predictors.Design/methodology/approachOn the individual level, the authors use data of a large-scale cross-cultural study, including 236.089 consumers from 30 countries worldwide. The authors apply several methods to test for the culture-boundness of pARS. First, they apply correlation analysis to replicate existing cross-cultural results and to ensure nomological validity. Second, applying ordinary least square regression, the authors simultaneously test the six Hofstede cultural dimensions (Hofstede et al., 2010) and investigate interactions between the dimensions. Finally, they use multi-level analysis to confirm the stability of culture-bound results, controlling for individual- and country-level variability.FindingsThe paper introduces an alternative measure for acquiescence (pARS), which is particularly suitable for shorter questionnaires. A large-scale consumer study with 236.089 respondents in 30 countries supports the culture-bound validity of pARS. The authors confirm construct validity and the nomological network of pARS. Contrasting existing studies, multi-level analysis demonstrates that a high level of power distance majorly leads to ARS. Therefore, cross-cultural researchers need to control for ARS in countries high in power distance, especially when paired with high uncertainty avoidance.Originality/valueA large-scale consumer study with 236.089 respondents from 30 countries shows that respondents from various countries differ significantly in their level of acquiescence. The study confirms that power distance is the most relevant cultural dimension to explain these differences. Although ARS may bias the results of comparative cross-cultural studies, it is rarely controlled by market research studies outside the academic realm. The present work proposes and establishes the validity of a practice-oriented measure of acquiescence, namely, pARS. pARS is particularly suitable for shorter questionnaires. In contrast to prior approaches, applying pARS does not require adding non-substantive items to the questionnaire.
Becoming a scholar by publication – PhD students citing in interdisciplinary argumentation
Authors: Gullbekk Eystein , Byström Katriina 
Published: December 2018

PurposeThe purpose of this paper is to analyse scholarly subjectivity in the context of citation practices in interdisciplinary PhD research.Design/methodology/approachThe paper provides an analysis of longitudinal series of qualitative interviews with PhD students who write scholarly articles as dissertation components. Conceptualizations of subjectivity within practice theories form the basis for the analysis.FindingsScholarly argumentation entails a rhetorical paradox of “bringing something new” to the communication while at the same time “establishing a common ground” with an audience. By enacting this paradox through citing in an emerging interdisciplinary setting, the informants negotiate subject positions in different modes of identification across the involved disciplines. In an emerging interdisciplinary field, the articulation of scholarly subjectivity is a joint open-ended achievement demanding knowledgeability in multiple disciplinary understandings and conducts. However, identifications that are expressible within the informants’ local site, i.e. interactions with supervisors, other seniors and peers, are not always expressible when negotiating subject positions with journals.Originality/valueThis paper contributes to research on citation practices in emerging interdisciplinary fields. By linking the enactment of citing in scholarly writing to the negotiation of subject positions, the paper provides new insights about the complexities involved in becoming a scholar.
Financing decisions of migrant family businesses: the case of a Ghanaian-owned shop in Kent
Authors: Boateng Bernard , Silva Mauricio , Seaman Claire 
Published: December 2018

PurposeThe purpose of this paper is to examine how a Ghanaian migrant family business in Kent makes financial decisions and measures business growth within the framework of Social Network theory and focussing on influences such as family, cultural and social factors.Design/methodology/approachCase study: migrant Ghanaian family business owner in Kent, first generation who migrated to the UK after the year 2000. The business is a small and medium enterprise and running the business as a family.FindingsThe narrative highlights important aspects of cultural and social factors that are not usually considered in credit analysis or applications for a relationship with a mainstream financial services institution. It is also indicated that family and personal attributes and culture had the most social capital for the shop owner to use or explore in taking her financial decisions. The discussions provide a basic framework for future research.Originality/valueThere is a gap in the research of Ghanaian migrant family businesses in the UK, in particular of their financial decision making process.