bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late to early velocity index as a predictor of iatrogenic femoral artery pseudoaneurysm recurrence in patients treated with ultrasound-guided thrombin injection
Authors: Kurzawski Jacek , Janion-Sadowska Agnieszka , Zandecki Łukasz , Janion Marianna , Sadowski Marcin 
Published: June 2019

IntroductionUltrasound-guided thrombin injection (UGTI) is the preferred treatment of pseudoaneurysms (psA). The potential risk of complications increases with the number of UGTI treatments needed for complete psA obliteration. Identification of risk factors for recurrent psA is needed.Material and methodsIn total, 508 patients with femoral artery psA underwent UGTI, followed by ultrasound examination repeated twice, at 1-week intervals, to assess UGTI effectiveness. In cases of psA recurrence, the procedure was repeated. Clinical and ultrasound data were prospectively collected.ResultsThe psA recurrence occurred in 76 (15%) patients. UGTI was repeated twice in 49 (64%), three times in 15 (20%) and more than three times in 12 (16%) patients. The median thrombin dose was 150 IU (80–250 IU), and was lower in initial procedures than repeated UGTI (p = 0.025). The median psA volume was 2.26 ml (0.86–5.47 ml). The median length of the communicating channel was 4 mm (0–12 mm). A time interval between vessel catheterization and UGTI greater than 7 days (p < 0.001), a late to early velocity index (LEVI) of < 0.2 identified during the outflow phase (p < 0.001), a psA volume > 5 ml (p = 0.032), and a short communicating channel between the psA and the artery (p = 0.037) predicted psA recurrence. Antiplatelet and anticoagulant agents did not increase the risk.ConclusionsThe LEVI and time interval between artery cannulation and UGTI treatment are strong parameters identifying patients at risk of psA recurrence. The psA volume and communicating channel length are less substantial risks, but still significant. Concomitant antiplatelet and anticoagulant therapy do not affect the success rate of UGTI.
Silent cerebral infarcts following pulmonary vein isolation with different atrial fibrillation ablation techniques – incidence and risk factors
Authors: Glowniak Andrzej , Tarkowski Adam , Janczarek Marzena , Wysokinski Andrzej 
Published: June 2019

IntroductionSilent cerebral infarcts (SCIs) detected by diffusion-weighted magnetic resonance (DW-MRI) following atrial fibrillation (AF) ablation have been reported, with the incidence of 1–38%. We aimed to compare the incidence of SCIs following AF ablation with four different technologies and analyze the risk factors.Material and methodsA total of 104 patients (mean age: 59.9 ±9.5 years, 68 males) with symptomatic AF, referred for ablation, were included in the study. The AF ablation was performed with irrigated radiofrequency point-by-point technique (RF group) in 24 patients, and with 3 different single-shot techniques: phased-RF (PVAC) in 46, second-generation cryoballoon (CB) in 24 and irrigated multipolar RF catheter (nMARQ) in 10 patients. In all patients DW-MRI was performed pre- and post-procedurally to evaluate the incidence of SCIs. Procedural parameters, complication rate and post-procedural SCI incidence were compared between the groups.ResultsProcedure (167.1 vs. 110.5 vs. 106.0 vs. 141.5 min, p < 0.001), fluoroscopy (22.7 vs. 15.9 vs. 16.3 vs. 15.3 min, p = 0.048) and LA dwell (101.5 vs. 53.9 vs. 56.0 vs. 97.0 min, p < 0.001) times compared respectively between RF, PVAC, CB and nMARQ groups were significantly shorter with single-shot techniques. The number of new-onset SCIs was 4/24 (16.7%) in RF, 7/46 (15.2%) in PVAC, 1/24 (4.2%) in CB and 1/10 (10%) in the nMARQ group. Univariate analysis identified procedure duration (p = 0.02), lower LV ejection fraction (p = 0.03), persistent form of arrhythmia (p = 0.007) and intraprocedural cardioversion (p = 0.002) as risk factors of new-onset SCIs.ConclusionsSilent cerebral infarcts can be detected following AF ablation regardless of the technology used. Prolonged procedure time, lower ejection fraction, persistent form of arrhythmia and intraprocedural cardioversion increase the risk of SCIs.
Modulation of Ki67 and myogenic regulatory factor
expression by tocotrienol-rich fraction ameliorates
myogenic program of senescent human myoblasts
Authors: Tan Chun Min , Mohd Najib Nadwa Aqeela , Suhaimi Nur Farahin , Halid Nur Alia , Cho Vi Vien , Abdullah Saiful Idham , Ismail Muhammad Zulhilmi , Khor Shy Cian , Jaafar Faizul , Makpol Suzana 
Published: June 2019

IntroductionReplicative senescence results in dysregulation of cell proliferation and differentiation, which plays a role in the regenerative defects observed during age-related muscle atrophy. Vitamin E is a well-known antioxidant, which potentially ameliorates a wide range of age-related manifestations. The aim of this study was to determine the effects of tocotrienol-rich fraction (TRF) in modulating the expression of proliferation- and differentiation-associated proteins in senescent human myoblasts during the differentiation phase.Material and methodsHuman skeletal muscle myoblasts were cultured until senescence. Young and senescent cells were treated with TRF for 24 h before and after differentiation induction, followed by evaluation of cellular morphology and efficiency of differentiation. Expression of cell proliferation marker Ki67 protein and myogenic regulatory factors MyoD and myogenin were determined.ResultsOur findings showed that treatment with TRF significantly improved the morphology of senescent myoblasts. Promotion of differentiation was observed in young and senescent myoblasts with TRF treatment as shown by the increased fusion index and larger size of myotubes. Increased Ki67 and myogenin expression with TRF treatment was also observed in senescent myoblasts, suggesting amelioration of the myogenic program by TRF during replicative senescence.ConclusionsTRF modulates the expression of regulatory factors related to proliferation and differentiation in senescent human myoblasts and could be beneficial for ameliorating the regenerative defects during aging.
Extraversion and focus of attention on facial emotions: an experimental eye-tracking study
Authors: Ellingsen Eline F. , Drevsjø Sandra , Volden Frode , Watten Reidulf G. 
Published: June 2019

BackgroundEmotions and personality traits seem to be important factors affecting social attention. In the present study, we used eye-tracking equipment to investigate the differences between extraverts and introverts in visual attention to positive and negative emotions shown in human faces. We want to describe more detailed types of eye movements in this visual attention, and especially pat-terns of spatial and temporal fixations. Based on previous research we would expect that extraverts would be more attentive to faces showing positive emotions compared to introverts.Participants and procedureEmotions and personality traits seem to be important factors affecting social attention. The current study investigated differences between extraverts’ and introverts’ visual attentional focus on positive and negative emotions expressed in human faces.ResultsCompared to the introverts group, extraverts showed significantly longer average fixation duration (AFD) for whole faces per-ceived to express positive emotions. There were no significant differences between the groups for dwelling time (DT), entry time (ET), and first fixation (FF). However, the extraversion group showed significantly longer DT, FF and AFD attention towards the mouth area compared to the introverts.ConclusionsExtraverts seem to show a selective visual attentional bias towards positive emotions in human faces, particularly towards the mouth area of smiling faces compared to introverts. The study showed that the visual mechanisms behind this selective attention were differences in temporal fixation patterns such as average fixation duration, dwelling time and first fixation time.
Diferencia de precios entre las distintas marcas de medicamentos y los medicamentos genéricos comentario de estudio hecho por ANADEUS
Authors: Cienfuegos Jorge 
Published: June 2019

Objetivo: Divulgar entre los investigadores en salud pública algunas propuestas de gráficos estadísticos multivariantes, tales como las caras de Chernoff, los gráficos de estrella, las curvas de Andrews y gráficos de radar.Material y método: Los gráficos estadísticos multivariantes propuestos son aplicados para describir los Sistemas de Salud Públicos de Chile, año 2010, (n=29) en base a información cuantitativa de dimensión p=7; ellos son procesados usando software estadísticos standard como R, STATA y SAS.Resultados: La descripción de los 29 Sistemas de Salud Públicos de Chile en base a información cuantitativa de dimensión siete, representados en cada uno de los gráficos multivariantes exhibidos, permite determinar conglomerados, estándares y tendencias.Conclusiones: La disponibilidad de eficientes software estadísticos sugiere complementar las indispensables estrategias de análisis exploratorio de nuestra información con representaciones gráficas adecuadas al contexto multidimensional que pueden ayudar a alcanzar una mejor comprensión del problema de interés. La síntesis gráfica generada por la aplicación de gráficos estadísticos multivariantes para describir los Sistemas de Salud Públicos de Chile complementa nuestro conocimiento de este aspecto de la realidad nacional, puede sugerir algunas hipótesis, refutar otras y ayudar en la interpretación de resultados complejos. Naturalmente esto es extensible a muchas otras situaciones de interés para el investigador salubrista.
Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods
Authors: Avdeef Alex 
Published: June 2019

This commentary compares 233 CheqSol intrinsic solubility values (log S0) reported in the Wiki-pS0 database for 145 different druglike molecules to the 838 log S0 values determined mostly by the saturation shake-flask (SSF) method for 124 of the molecules from the CheqSol set. The range of log S0 spans from -1.0 to -10.6 (log molar units), averaging at -3.8. The correlation plot between the two methods indicates r2 = 0.96, RMSE = 0.34 log unit, and a slight bias of -0.07 log unit. The average interlaboratory standard deviation (SDi) is slightly better for the CheqSol set than that of the SSF set: SDiCS = 0.15 and SDiSSF = 0.24. The intralaboratory errors reported in the CheqSol method (0.05 log) need to be multiplied by a factor of 3 to match the expected interlaboratory errors for the method. The scale factor, in part, relates to the hidden systematic errors in the single-lab values. It is expected that improved standardizations in the ‘gold standard’ SSF method, as suggested in the recent ‘white paper’ on solubility measurement methodology, should make the SDi of both methods be about ~0.15 log unit. The multi-lab averaged log S0 (and the corresponding SDi) values could be helpful additions to existing training-set molecules used to predict the intrinsic solubility of drugs and druglike molecules.
Candida auris: An Emerging Yeast Pathogen Posing Distinct Challenges for Laboratory Diagnostics, Treatment, and Infection Prevention
Authors: Hata D. Jane , Humphries Romney , Lockhart Shawn R. ,   for the College of American Pathologists Microbiology Committee
Published: June 2019

Context.—Candida auris is an emerging yeast species that was first described in 2009. This ascomycetous yeast is notable for resistance to azole antifungal agents, for environmental persistence, and for its ability to contaminate health care environments, resulting in patient colonization and nosocomial infections.Objective.—To review the state of current knowledge addressing challenges in the accurate identification of C auris in the diagnostic microbiology laboratory, including application of phenotypic, proteomic, and genomic methodologies; characteristics that may predispose the human host to acquiring C auris; transmission; clinical presentations; treatment modalities; environmental decontamination; and infection prevention in health care settings.Data Sources.—The PubMed search engine was used to access peer-reviewed literature published from 2009 to 2019.Conclusions.—The rapid emergence of C auris has presented unique challenges for the areas of laboratory diagnostics and infection prevention and in options for antifungal treatment, which are limited. The current lack of established antifungal susceptibility test breakpoints complicates therapeutic decision making. Enhanced awareness of this pathogen is essential to monitor outbreaks and to reduce the risk of spread within health care environments.
Chine, Éthiopie, Djibouti : un triumvirat pour la Corne de l’Afrique ?
Authors: Le Gouriellec Sonia 
Published: June 2019

Située sur une des routes maritimes les plus utilisées au monde, la Corne de l’Afrique est une étape essentielle du projet chinois Nouvelles routes de la soie (Belt and Road Initiative –bri) en Afrique. Dans cette région, il se traduit par un afflux de contrats de construction dans les infrastructures portuaires et ferroviaires. Nous proposons ici de renverser le regard et d’analyser la stratégie des acteurs locaux en mobilisant le concept d’extraversion. L’asymétrie des relations entre la Chine et les pays de la région n’est pas subie. Elle est acceptée et devient même un mode d’action pour les régimes locaux. Nous nous intéresserons plus particulièrement aux relations entre la Chine, l’Éthiopie et Djibouti. Ces relations sont basées sur un partenariat économique et politique. Les Nouvelles routes de la soie renforcent un ordre régional établi autour de la puissance régionale éthiopienne.
A primer on standardized testing: History, measurement, classical test theory, item response theory, and equating
Authors: Himelfarb Igor 
Published: June 2019

Objective:This article presents health science educators and researchers with an overview of standardized testing in educational measurement. The history, theoretical frameworks of classical test theory, item response theory (IRT), and the most common IRT models used in modern testing are presented.Methods:A narrative overview of the history, theoretical concepts, test theory, and IRT is provided to familiarize the reader with these concepts of modern testing. Examples of data analyses using different models are shown using 2 simulated data sets. One set consisted of a sample of 2000 item responses to 40 multiple-choice, dichotomously scored items. This set was used to fit 1-parameter logistic (PL) model, 2PL, and 3PL IRT models. Another data set was a sample of 1500 item responses to 10 polytomously scored items. The second data set was used to fit a graded response model.Results:Model-based item parameter estimates for 1PL, 2PL, 3PL, and graded response are presented, evaluated, and explained.Conclusion:This study provides health science educators and education researchers with an introduction to educational measurement. The history of standardized testing, the frameworks of classical test theory and IRT, and the logic of scaling and equating are presented. This introductory article will aid readers in understanding these concepts.
Land Suitability Evaluation for Rubber in the Tropical Humid Region of Kerala, India
Authors: Chandrakala M. , Srinivasan R. , `Kumar K. S. Anil , Sujatha K. , Hegde Rajendra , Singh S. K. , Nirmala H. R. 
Published: June 2019

Aims: To assess the suitability of the rubber in Elamdesam block, Idukki district, Kerala.
Place and Duration of Study: Soil survey done and soil samples were brought from Elamdesam block, Idukki district, Kerala, India in the year 2016 and laboratory characterization and suitability assessment was done during 2017 in National Bureau of Soil Survey and Land Use Planning, Regional Centre, Hebbal, Bangalore
Methodology: Soil suitability of rubber in Elamdesam block has been worked out in two steps. In the first step suitability criteria for rubber crop have been evolved with the help of existing literature with special reference to a tropical humid region of India. Emphasis was placed on land characteristics or land qualities which determine the limitations. Together, these diagnostic features (limitations) determine soil suitability when matched with crop or ecological requirements. In the second step, the defined suitabilities are shown on soil maps according to the map legend (soil composition) to prepare a relative suitability map for rubber in Elamdesam block.
Results: Results revealed that rubber is moderately suitable in the area constituted 23.4 per cent of the total with the limitation of root restriction, soil fertility, topography and soil texture. Marginally suitable in 20.75 per cent of the total geographical area with the limitation of topography, root restriction and soil fertility and 20.23 per cent of the total area is unsuitable with the limitation of depth to water table and root restriction in the Elamdesam block.
Conclusion: More than 60 per cent of the total geographical area is under rubber cultivation in Elamdesam block, Idukki district, Kerala apart from soils are having the limitation of root restriction, soil fertility, topography, depth to water table and soil texture.
Petroleum Pollution and Decrease Neuroplasticity in Brain Development of the Ogoni Children in Rivers State, Nigeria
Authors: David Lekpa Kingdom , Bodo Tombari , Gimah Batombari Gbidum 
Published: June 2019

Background: Health and mental related illnesses has emerged as a new challenge in the rural and undeveloped areas in Ogoniland where petroleum exploration activities have devastated the entire ecosystem. Many of the school children are no longer zealous about their academic activities, as their performances in school are always very poor. It has been reported that the children’s poor performance in school is closely linked with several health and mental challenges suffered by these children in the highly polluted areas.
Methods: The study comprises of 383 primary school teachers selected from 8 rural communities in the four (4) Ogoni Local Government Areas (Gokana, Tai, Eleme and Khana) in Rivers State where massive environmental pollution has been reported. Structured questionnaires were used to collect the data from the teachers on the children’s exposure to oil pollution; self-rated mental illnesses and behavioural symptoms among the school children, perception to petroleum pollution and mental illnesses.
Results: The results revealed that the signs of mental illnesses like anxiety disorder, attention-deficit disorder, autism spectrum disorder, mood disorder, schizophrenia and eating disorder were noticeable among the school children. The children also exhibited behavioural challenges such as extreme fear, difficulty in concentrating, self-imposed injuries, aggressive behaviour, avoiding other classmates and poor academic performances. The field survey further revealed that mental illnesses and behavioural challenges were common in areas of massive petroleum pollution of the environment. Other causes of these illnesses were revealed to be poverty and psychoactive substance use.
Conclusion: It was concluded that constant exposures of the children to environmental pollution is associated with decreasing neuroplasticity of the brain.
B
ryobacteraceae
Authors: Dedysh Svetlana N. 
Published: June 2019

Abstract

Bry.o.bac.te.ra.ce'ae. N.L. masc. n.
Bryobacter
type genus of the family; ‐
aceae
ending to denote a family; N.L. fem. pl. n.
Bryobacteraceae
the
Bryobacter
family.

Acidobacteria / Acidobacteriia / Bryobacterales / Bryobacteraceae

The family
Bryobacteraceae
accommodates Gram‐negative, aerobic and facultatively anaerobic, non‐spore‐forming, and mildly acidophilic bacteria, which divide by binary fission. Members of this family are chemoheterotrophs, which utilize various sugars and heteropolysaccharides. Some representatives are capable of reducing Fe(III) and nitrate. They are mesophilic and psychrotolerant bacteria. Major fatty acids are iso‐C
15:0
and C
16:1
ω7
c
; the cells also contain significant amounts of 13,16‐dimethyl octacosanedioic acid. Habitats are acidic wetlands and soils. The family belongs to the class
Acidobacteriia
, order
Bryobacterales
.

DNA G + C content (genome sequence) (mol%)
: 58.0–61.9.

Type genus
:
Bryobacter
Kulichevskaya, Suzina, Liesack and Dedysh 2010, 304
VP
.
P
aludibaculum
Authors: Dedysh Svetlana N. 
Published: June 2019

Abstract

Pa.lu'di.ba'cu.lum. L. n.
palus –udis
a swamp, marsh; N. neut. n.
baculum
a stick, rod; N.L. neut. n.
Paludibaculum
rod‐shaped bacterium from wetland.

Acidobacteria / Acidobacteriia / Bryobacterales / Bryobacteraceae / Paludibaculum

The genus
Paludibaculum
is represented by Gram‐negative, non‐spore‐forming, and nonmotile rods that occur singly, in pairs, or in short chains and reproduce by binary fission. These bacteria are facultatively anaerobic, mildly acidophilic, and mesophilic chemoorganotrophs, which utilize sugars and some polysaccharides. The only currently described species of this genus,
Paludibaculum fermentans
, was isolated from a littoral wetland of a boreal lake. Capable of fermentation and dissimilatory Fe(III) reduction under anoxic conditions. Major fatty acids are iso‐C
15
:0
and C
16
:1
ω7
c
; the cells also contain significant amounts of 13,16‐dimethyl octacosanedioic acid. The quinone is MK‐8. Known habitats are acidic wetlands and groundwater bodies. Members of the class
Acidobacteriia
, order
Bryobacterales
, family
Bryobacteraceae
.

DNA G + C content (mol%)
: 60.5.

Type species
:
Paludibaculum fermentans
Kulichevskaya, Suzina, Rijpstra, Sinninghe Damsté and Dedysh 2014, 2861
VP
.
The NLRP3 p.A441V Mutation in NLRP3‐AID Pathogenesis: Functional Consequences, Phenotype‐Genotype Correlations and Evidence for a Recurrent Mutational Event
Authors: Awad Fawaz , Assrawi Eman , Jumeau Claire , Odent Sylvie , Despert Veronique , Cam Gérard , Perdriger Aleth , Louvrier Camille , Cobret Laetitia , Copin Bruno , Chantot‐Bastaraud Sandra , Duquesnoy Philippe , Piterboth William , Le Jeunne Claire , Quenum‐Miraillet Genevieve , Siffroi Jean Pierre , Georgin‐Lavialle Sophie , Grateau Gilles , Legendre Marie , Giurgea Irina , Karabina Sonia‐Athina , Amselem Serge 
Published: June 2019

ObjectiveTo determine the molecular and cellular bases of autoinflammatory syndromes in a multigenerational French family with Muckle‐Wells syndrome and in a patient originating from Portugal with familial cold autoinflammatory syndrome.MethodsSequencing of NLRP3 exon 3 was performed in all accessible patients. Microsatellite and whole‐genome single nucleotide polymorphism genotyping was used i) to test the intrafamilial segregation of the identified variant and ii) to look for a founder effect. Functional analyses included the study of i) apoptosis‐associated speck‐like protein containing a CARD (ASC) speck formation in HEK293T cells (stably expressing ASC–green fluorescent protein and pro‐caspase 1‐FLAG) transiently expressing the wild‐type or mutated NLRP3 protein, ii) levels of IL‐1β secreted from transfected THP‐1 cells, and iii) inflammasome‐related gene expression and cytokine secretion from monocytes isolated from patients in crisis (probands from the two families), related patients out of crisis, and from controls.ResultsThe same heterozygous mutation (c.1322C>T, p.A441V) located in the NACHT domain, segregating with the disease within the first family, was identified in the two families. This mutation was found to be associated with different core haplotypes. NLRP3‐A441V led to increased ASC speck formation and high levels of secreted IL‐1β. Monocyte inflammasome‐related gene expression and cytokine secretion, which were within the normal range in patients out of crisis, were found to be differentially regulated between the two probands, correlating with their phenotypic status.ConclusionThese molecular and cellular findings, which indicate a recurrent mutational event, clearly demonstrate the pathogenicity of the p.A441V missense mutation in NLRP3‐associated autoinflammatory disease and point to the interest of studying patients’ primary cells to assess disease activity.