bluuebunny/crossref_metadata_2025_split huggingface dataset:
The experience of pedagogical training on postgraduate rehabilitation health professionals: A qualitative study
Authors: Bertoni Gianluca , Giardulli Benedetto , Minozzi Barbara , Coppola Ilaria , Furri Laura , Testa Marco , Battista Simone 
Published: December 2024

Introduction
Health professionals that act as lecturers in higher education necessitate the acquisition of pedagogical skills along with clinical ones. Consequently, pedagogical training courses have been introduced as part of professional development or within university curricula. While several studies explored the experiences of attending courses on pedagogical methodology, there is a notable gap in the literature within the rehabilitation field. Hence, this qualitative study explored the experience of Italian postgraduate health professionals in rehabilitation about the experience of attending pedagogical methodology courses in their postgraduate education.

Materials and methods
A qualitative focus group study was carried out. Specifically, the authors purposefully recruited participants with different professional backgrounds (physiotherapy, speech therapy, and others) with or without lecturing experience. Recent graduates and students of the Master of Science in ’Rehabilitative Sciences of the Health Professions’ at the University of Verona (Verona, Italy) were recruited. The focus groups were analysed following a ’Reflexive Thematic Analysis’ by Braun & Clarke within a social constructionist framework.

Results
Three focus groups were conducted with seventeen Italian participants (age: 33 ± 9; 71% women, n = 12; 29% men, n = 5). The analysis identified three main themes: 1) “A Brave New Pedagogical World,” reflecting participants’ exposure to innovative teaching approaches; 2) “Becoming a Cutting-Edge Lecturer,” highlighting skills acquired for delivering inspiring lectures; and 3) “Something Beyond Pedagogy,” where participants reported skills applicable to other professional contexts, including clinical practice.

Conclusion
The results of this study showed that pedagogical courses provide a positive learning experience for rehabilitation health professionals, helping them develop relevant pedagogical skills. Although our findings suggest the potential benefits of these courses in preparing healthcare professionals for teaching roles, further studies are needed to evaluate their direct impact on educational practices and patient outcomes.
Pneumococcal nasopharyngeal carriage in children and adults self-confined at home during a COVID-19 national lockdown
Authors: Brotons Pedro , Cisneros María , Pérez-Argüello Amaresh , Henares Desiree , Lluansí Aleix , Fernández de Sevilla Mariona , Ciruela Pilar , Blanco-Fuertes Miguel , Launes Cristian , Jordan Iolanda , Bassat Quique , García-García Juan José , Muñoz-Almagro Carmen 
Published: December 2024

Background
Despite growing evidence of reduced invasive and non-invasive pneumococcal disease attributed to public health measures against the COVID-19 pandemic, the effect of these measures on pneumococcal carriage remains unclear. This study aimed to assess pneumococcal nasopharyngeal carriage among children and adults self-confined at home during the COVID-19 national lockdown in Spain while identifying predictors of pneumococcal carriage in children.

Methods
Household study conducted across the metropolitan area of Barcelona (Spain) between April-June 2020. Nasopharyngeal samples were collected from young children and adults for real-time PCR pneumococcal lytA and wgz gene detection, quantification, and serotyping, as well as for detection of respiratory viruses.

Results
Among 332 children (median age: 3.1 years [IQR: 1.9–4.0 years]; 59% male) and 278 adults (median age: 38.9 years [IQR: 36.1–41.3 years]; 64% female), pneumococcal carriage rates were 28.3% and 2.5%, respectively. Highly invasive serotypes 3, 7F/7A, and 19A were detected in 14.0% of samples from children carriers. Pneumococcal co-infections with respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and influenza virus (IV) were not identified in children. Attendance to kindergarten before the lockdown (aOR: 2.65; IQR: 1.57–4.47; p<0.001) and household crowding (aOR: 1.85; IQR: 1.09–3.15; p = 0.02) were independent risk factors for children’s pneumococcal carriage.

Conclusions
Pneumococcal carriage rate among quarantined children during a full COVID-19 lockdown was moderate and correlated with limited presence of highly invasive serotypes and absence of pneumococcal co-infections with RSV, hMPV, and IV. Pre-lockdown daycare and household crowding predisposed children to carriage.
Variability, association and cluster analysis of backcross derived lines in black gram [Vigna mungo (L.) Hepper]
Authors: Hegde Prasanna Mahabaleshwar , Narayana Manivannan , Dharmalingam Kumaresan , Ramasamy Saminathan Vangily , Govindasamy Senthilraja 
Published: December 2024

A BC2F4 population of black gram was derived from a cross between a high-yielding variety (MDU 1) and a bruchid-resistant donor (TU 68). Twenty-four backcross-derived lines (BLs) of this population were evaluated for yield and yield components. Eight BLs had at par seed yield with MDU 1. Variability studies showed high PCV (%), GCV (%), heritability (%) and GAM (%) for plant height, number of branches per plant, number of clusters per plant, number of pods per plant and seed yield per plant. Correlation analysis for yield components revealed that all traits significantly and positively correlated with seed yield per plant. Path analysis on seed yield per plant indicated that the number of pods and hundred seed weight had a high and moderate direct effect on seed yield per plant. Hence, these two traits should be used as seed yield improvement programme selection indices. Cluster analysis grouped the progenies into three major clusters. Most of the progenies that are at par with MDU 1 for yield were clustered together. The promising high-yielding progenies identified may be tested for their bruchid resistance and released as a variety after the large-scale evaluation.
Nonlocal modeling of continuously stirred tank reactors with residence time distribution
Authors: Ochoa-Tapia J. Alberto , Alvarez-Ramirez Jose 
Published: December 2024

Abstract
The residence time distribution (RTD) has an important impact in the performance of chemical reacting systems. The segregated fluid assumption is commonly used to assess the analysis and design of chemical reactors. Models derived from the segregated fluid assumption for continuously stirred tank reactors (CSTR) rely on batch reactor models. A drawback of such assumption is that the CSTR model structure is not recovered in the limit when the RTD becomes very narrow (e.g., a Dirac delta). The aim of the present work is to propose a nonlocal modeling approach that is consistent with the CSTR model structure. The main idea is to represent the reactor as a continuum of tiny differential CSTRs determined by the RTD. The resulting nonlocal model is expressed as integrodifferential equations representing the interaction of reactive molecules of a given residence time with molecules of all residence times. By doing this, the nonlocal model is reduced to the usual CSTR model in the limit when the RTD is very narrow. The methodology was illustrated with three worked cases of dimerization, autocatalytic and series reaction schemes, and the results were compared with that obtained with the segregated fluid assumption. It was found that nonlocal models predict lower conversions than the segregated fluid models.
Crustal deformation in East of Cairo, Egypt, induced by rapid urbanization, as seen from remote sensing and GNSS data
Authors: Nabil Ahmed , El-Ashquer Mohamed , Saleh Mohamed , Mousa Ashraf El-Kutb , El-Fiky Gamal Saber 
Published: December 2024

Abstract
The area located East to Cairo, the Capital of Egypt, represents an obvious example for the rapid urban expansion, as it contains many new housing cities. Beside its socio-economic importance, it’s located in the Cairo-Suez seismic zone. We utilized Persistent Scatterer Interferometry (PSI) of 2015–2021 Sentinel-1 SAR scenes along with two GNSS stations (KATA and PHLW) to assess the distribution and rates of crustal deformation of this region. The PSI analysis is applied to 140 Sentinel-1 SAR images collected from the ascending track number (58) and the descending track number (167). The Bernese software V. 5.0 is used for the processing of the GNSS data. A good agreement between the rates estimated from the PSI analysis and GNSS data is observed. Based on results, most of the new cities showing land subsidence with variable rates. The rates at Obour, New Cairo, Shorouk, Madinty, and Capital Gardens are 0.54 ± 0.30 mm/year, 0.58 ± 0.30 mm/year, 1.01 ± 0.30 mm/year, 0.58 ± 0.30 mm/year, and 0.99 ± 0.30 mm/year, respectively. The highest recorded subsidence rates are at Asher, Administrative Capital, and Badr with 2.18 ± 0.30 mm/year, 1.89 ± 0.30 mm/year, and 1.69 ± 0.30 mm/year, respectively. Nasr city is the only city with an uplift of 0.82 ± 0.30 mm/year. Our new findings introduce the probable use of integrated techniques such as GNSS and InSAR to evaluate the extent of crustal deformation connected to rapid urbanization in arid areas. Beside tectonic setting, it should be considered while executing mega-projects for sustainable development especially within Egypt’s Vision 2030.
One-pot green synthesis of zinc oxide nanoparticles using Morus laevigata aqueous extract and evaluation of its anticancer potential against HT-29 cell line
Authors: Paranthaman Sathishbabu , Shivakumar C. S. , Kalaipriya S. , Venkatesh Hosur Narayanappa , Gireesha J. , Pasha Shuaib , Shazly Gamal A. , Anandan Satish , Shivamallu Chandan , Kollur Shiva Prasad 
Published: December 2024

Abstract
Colon cancer presents significant challenges in treatment efficiency and patient outcomes, necessitating innovative, effective strategies due to the adverse effects of conventional therapies. The study aimed to investigate the green synthesis of zinc oxide nanoparticles (ZnO NPs) using aqueous extract of Morus laevigata (ML) leaves and their potential biomedical applications. ML-ZnO NPs were characterized using analytical techniques. The absorption band at 330 nm was detected by UV–Vis spectroscopy, confirming the formation of ML-ZnO NPs. An average size of 68.5 ± 1.85 nm and a negative zeta potential of −11.1 ± 0.98 mV confirm the stability of nanoparticles in colloidal solutions. FTIR analysis confirmed ML-ZnO NPs, with absorption bands corresponding to Zn–O stretching vibrations and aliphatic CH and CH2 groups. SEM examination revealed diverse patterns including cauliflower-like formations. Further anticancer activity of ML-ZnO NPs was assessed through cell viability, cell cycle, and apoptosis assays. ML-ZnO NPs inhibited HT-29 cell growth dose dependently, exceeding cisplatin 56.33 ± 0.87% cell viability. Cell cycle arrest at the G2M phase in HT-29 cells treated with ML-ZnO NPs was noticeable, further validated by apoptosis, which showed large increases in apoptotic cell populations. These results may pave the way for future research investigating the potency of ZnO NPs derived from plant extracts to manage colon cancer.
Reducing artifact generation when using perceptual loss for image deblurring of microscopy data for microstructure analysis
Authors: Krawczyk Patrick , Gaertner Marvin , Jansche Andreas , Bernthaler Timo , Schneider Gerhard 
Published: December 2024

Abstract
Materials microstructure analysis is a crucial task for understanding the relationship between a material’s structure and its properties. The quality of the acquired images is vital, as blurring can result in the loss of essential information needed for microstructure analysis. This issue becomes more apparent with higher magnification and the corresponding decrease in depth of field (D.O.F.). To address this, new AI-based approaches are being explored to automatically improve image quality. Experts are testing innovative loss functions for training AI models to improve the image deblurring performance and thus a better image reconstruction. In the research field of image deblurring, it is known that pixel-based loss functions badly correspond with human perception of image quality. Therefore, a perceptual loss term is used for better visual reconstruction results. However, it has been shown that a perceptual loss term can lead to visible artifacts. Current literature has not yet sufficiently investigated why these artifacts are generated. In this work, we tackle this lack of research and provide new insights into the generation of such artifacts. We not only show that artifact generation is caused by the feature map used for the perceptual loss, but we also show that the level of distortion in the input impacts the extent of the artifact generation. Furthermore, we show that common metrics are insensitive to these artifacts, and we propose a method to reduce the extent of the generated artifacts.
Advancements in surface-enhanced femtosecond stimulated Raman spectroscopy: exploring factors influencing detectability and shapes of spectra
Authors: Pyrcz Patryk , Gawinkowski Sylwester 
Published: December 2024

Abstract
A combination of femtosecond stimulated Raman scattering and surface-enhanced Raman scattering, termed surface-enhanced stimulated Raman scattering (SE-FSRS), was proposed to leverage both temporal precision and sensitivity for advanced molecular dynamics analysis. During the initial successful implementations of this approach, unexpected spectral distortions were observed, and several potential explanations were proposed. Further progress in this novel technique and its broader implementation requires a profound understanding of the factors influencing the shape of the registered spectra and the underlying mechanisms. Here we present findings on how pulse energy and excitation wavelengths affect SE-FSRS spectra, emphasizing the influence of a strong broadband background on spectral dispersion. These insights contribute to understanding the complex mechanisms underlying SE-FSRS and suggest methods to improve the control and application of this spectroscopic technique, highlighting its potential to provide deeper insights into molecular dynamics. This work represents a significant step toward exploiting SE-FSRS for advanced analytical applications.
Para decolonizar os museus: desafios e possibilidades
Authors: Madeira de Melo Roberta , Viera da Rosa Elza , Rosane Possamai Zita 
Published: December 2024

Trata-se de uma reflexão crítica que problematiza a decolonização dos museus através da análise de algumas práticas decoloniais em curso no Brasil. Dentre estas iniciativas, este artigo destaca o Museu de Percurso do Negro em Porto Alegre como uma experiência concebida na perspectiva decolonial e antirracista. Compreende-se que os projetos que buscam a decolonização dos museus, mesmo passíveis a equívocos, potencializam a agência dos espaços museais no âmbito da valorização patrimonial, cultural e histórica de grupos que, historicamente, foram negligenciados por estas instituições.
Memórias do “sonho desagradável”
Authors: Dos Reis Santos Desirree , Castro Mendonça Elizabete , Lima e Souza Monica 
Published: December 2024

O Rio de Janeiro foi o maior porto escravagista das Américas. Esta afirmativa ganhou maiores proporções a nível local e global, a partir do reconhecimento do Cais do Valongo como Patrimônio Mundial em 2017. Em torno do Valongo, um antigo complexo escravista, diferentes atores sociais vinham exigindo a criação de um museu público, de modo a narrar a presença negra na história do Cais, do Brasil e do mundo atlântico. Este artigo analisa tais demandas por musealização, visando identificar enquadramentos de narrativas de dor e sofrimento associadas a este lugar de memória sensível e utilizados em releituras do passado escravista desenvolvidas por diferentes agentes na cena pública. Para tanto, tem como foco de análise textos publicados em redes sociais virtuais e na imprensa, em janeiro de 2017, acerca da intenção da municipalidade de criar um museu sobre a escravização atlântica. Considera, por fim, que a complexidade da construção de narrativas públicas de dor e sofrimento transita entre o não reconhecimento social da violência política dos crimes da escravidão e do racismo, a dificuldade de suplantar memórias coloniais de desumanização e as lutas políticas históricas pela afirmação de resistências negras.
Palavras-chave: Musealização; Museu da Escravidão e da Liberdade (MEL), Cais do Valongo.
Performance of the AmpliSeq NGS panel in thyroid nodules with indeterminate cytology
Authors: Potonnier Wiame , Guillerm Erell , Bigorgne Claude , Ghander Cécile , Roy Malanie , Coulet Florence , Ansart François , Menegaux Fabrice , Leenhardt Laurence , Brocheriou Isabelle , Deniziaut Gabrielle , Buffet Camille 
Published: December 2024

ObjectiveFine-needle aspiration (FNA) cytological analysis fails to confirm the benignity or malignancy of Bethesda III, IV and V thyroid nodules. Molecular tests performed on FNA samples have demonstrated interesting results in improving the diagnosis of these nodules. The aim of this study was to assess the performance of a large next-generation sequencing (NGS) panel in thyroid nodules with indeterminate cytology (Bethesda III, IV and V).MethodsRetrospective, monocentric study including 121 patients with cytologically indeterminate thyroid nodules (Bethesda III, IV and V) who underwent a routine FNA procedure for molecular testing using the AmpliSeq general cancer NGS panel, with an available final histological diagnosis. The main objective was to estimate the negative predictive value (NPV) of malignancy of the AmpliSeq panel in Bethesda III and IV thyroid nodules. Performance assessment (sensitivity, specificity, positive predictive value (PPV) and NPV) was carried out in the grouped categories III and IV, in the overall cohort and in each Bethesda category. The final histological diagnosis was used as the designated gold standard.ResultsHistologically, 86 nodules were benign and 35 nodules were malignant. Molecular analysis yielded a positive result in 40 nodules. Panel performances assessed in the grouped categories Bethesda III and IV demonstrated a 55.0% (95% CI: 31.5; 76.9) sensitivity, a 76.9% (95% CI: 66.0; 85.7) specificity, a 37.9% (95% CI: 25.7; 51.9) PPV and an 87.0% (95% CI: 80.2; 91.7) NPV, considering a 20% prevalence of malignancy.ConclusionsThe performances of the AmpliSeq panel are promising; however, the NPV is not sufficient to avoid diagnostic surgery in cytologically indeterminate thyroid nodules.Significance statementDifferent ancillary molecular tests have been marketed in the USA and are integrated into the management of thyroid nodules with indeterminate cytology. Unfortunately, none of these molecular tests are currently available in France and clinicians lack effective tools for the management of these nodules. The aim of this work was to assess the performance of a large general-cancer targeted NGS panel in a series of thyroid nodules with indeterminate cytology (i.e. Bethesda III and IV categories and, to some extent, the Bethesda V category), managed in a French university medical center referral for thyroid tumors.
Left Ventricular Remodeling Predictors in Chronic Heart Failure of Ischemic Etiology
Authors: Ageev A. A. , Kozhevnikova M. V. , Tyurina D. A. , Korobkova E. O. , Kondratieva T. O. , Shestakova K. M. , Moskaleva N. E. , Markin P. A. , Khabarova N. V. , Appolonova S. A. , Belenkov Yu. N. 
Published: December 2024

Aim To identify metabolomic and structure and function markers of remote left ventricular (LV) remodeling in patients with chronic heart failure (CHF) of ischemic etiology and LV ejection fraction (EF) <50%.Material and methods This prospective study included 56 patients with 3-4 NYHA functional class CHF of ischemic etiology (mean age, 66±7 years) and 50 patients with ischemic heart disease (IHD) without signs of CHF (69 [64; 73.7] years). Concentration of 19 amino acids, 11 products of kynurenine catabolism of tryptophan, 30 acylcarnitines with different chain lengths were measured in all participants. The metabolites that showed statistical differences between the comparison groups were then used for the analysis. Echocardiography was used to assess LV cavity remodeling at the time of the CHF patient inclusion in the study and after 6 months of follow-up. Predictors of long-term LV cavity remodeling were assessed for this cohort taking into account statistically significant echocardiographic parameters and metabolites.Results Patients with CHF of ischemic etiology, predominantly (81%) had pathological calculated types of LV remodeling (concentric and eccentric hypertrophy, 46 and 35%, respectively). However, this classification had limitations in describing this cohort. In addition, in this group, the concentrations of alanine, proline, asparagine, glycine, arginine, histidine, lysine, valine, indolyl-3-acetic acid, indolyl-3-propionic acid, C16-1-OH, and C16-OH were significantly (p<0.05) lower, and the concentrations of most medium- and long-chain acylcarnitines were higher than in patients with IHD without signs of CHF. The long-term (6 months) reverse remodeling of the LV cavity in CHF of ischemic etiology was influenced by changes in the interventricular septum thickness (hazard ratio, HR, 19.07; 95% confidence interval, CI, 1.76-206.8; p=0.006) and concentrations of anthranilic acid (HR 19.8; 95% CI 1.01-387.8; p=0.019) and asparagine (HR 8.76; 95% CI 1.07-71.4; p=0.031).Conclusion The presence of an interventricular septum thickness of more than 13.5 mm, anthranilic acid concentrations of higher than 0.235 μM/l, or an asparagine concentration of less than 135.2 μM/l in patients with CHF of ischemic etiology after 6 months of follow-up affects their achievement of LV cavity reverse remodeling.
"Not Just Plants, but Also Plants": A Political Ontology of Poh&atilde; &Ntilde;ana, the Medicinal Plants of the Guarani-Kaiow&aacute;
Authors: Essam Alice 
Published: December 2024

This article explores the political ontology of the Guarani-Kaiowá, Indigenous people of today’s Mato Grosso do Sul in Brazil, and their medicinal plants, pohã ñana. The contention, articulated by a Brazilian public health research team, that these plants are ‘not just plants, but also plants’ is investigated and traced back to cosmology. The inseparability of cosmology, ontology, epistemology and practices in relation to medicinal plants and the Guarani-Kaiowá is demonstrated and presented as 'storied performativity' (Blaser 2014). The article shows how the political ontology of the Guarani-Kaiowá is shaped by their resistance against agribusiness development in Indigenous lands and forests, along with their struggle to realise a cosmo-political life, which includes medicinal plants found (and lost) in the forests that have become monoculture. Medicinal plants and associated knowledge and practices have thus become important features of their resistance and political ontology. The article also reviews recent collaborations between Indigenous and non-Indigenous researchers regarding these knowledges and practices that attempt to bring Indigenous knowledge and politics into dialogue with Western epistemology, an important challenge for the harmonious co-existence of multiple ontologies, otherwise conceptualised as the ‘pluriverse’. Blaser’s political ontology framework helps to reveal the multiple dimensions to this Indigenous ontology.