bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism of Benzoinum in the Treatment of Ischemic Stroke Based on
Network Pharmacology and Molecular Docking
Authors: Ma Rong , Lu Danni , Xie Qian 
Published: December 2024

Object:
Benzoinum is a traditional Chinese medicine used to treat ischemic stroke. However,
the mechanism of action of benzoinum for treating ischemic stroke still remains unclear. This
study aims to elucidate the mechanism of benzoinum for treating ischemic stroke based on network
pharmacology and molecular docking, which will explore its key targets and provide a basis and new
treatment ideas for its clinical application.

Methods:
Targets associated with ischemic stroke were retrieved from the Genecards database using
the keywords "Ischemic stroke" and "Cerebral ischemia." Network pharmacology analysis was conducted,
and a network diagram encompassing drugs, components, targets, and diseases was constructed.
The analysis was performed using the Intelligent Network Pharmacology Platform Unique
for Traditional Chinese Medicine (INPUT). PPI enrichment analysis was utilized to identify key
target genes; GO and KEGG enrichment analyses were carried out to ascertain the primary biological
processes, molecular functions, cellular components, and pathways involved. A target network diagram
was generated to identify the most enriched targets. The interaction between compounds and
targets was determined via molecular docking.

Results:
A total of 65 active ingredients from benzoinum were identified as potentially effective for
the treatment of ischemic stroke. Potential active substances, oleanolic acid, 2,3,5,7-
Tetrahydroxyflavone, naphthalene, eucalyptol, and benzoic acid were ranked according to their degree
values. In addition, 226 targets were found to be involved in the process. The PPI topology
analysis revealed that the core targets included TP53, JUN, STAT3, AKT1, PIK3CA, RELA,
MAPK1, MAPK3, TNF, and CXCL8. GO enrichment analysis yielded 6807 entries, with 5589 entries
in BP, 385 entries in CC, and 833 entries in MF. KEGG enrichment analysis resulted in 290
entries, primarily related to lipid and atherosclerosis, PI3K-Akt pathway, chemical carcinogenesis
receptor activation, IL-17 pathway, and TNF pathway. Molecular docking also demonstrated the
interactions between the principal compounds and their respective targets.

Conclusion:
Benzoinum appears to exert therapeutic effects on ischemic stroke through multiple
components, targets, and pathways, with a primary association with its anti-inflammatory properties.
However, further experimental validation is recommended to more accurately define its active constituents
and mechanisms of action.
Effectiveness and Safety of Metformin, Teneligliptin, and Glimepiride Combination Therapy in Type 2 Diabetes: A Quasi Experimental Clinical Trial
Authors: Manchi Rajesh Kumar , Chenchula Santenna , Haritha Manchi 
Published: December 2024

Introduction:
Type 2 Diabetes Mellitus (T2DM) accounts for more than 95% of all
diabetes cases and is a leading cause of disability and death. This study aimed to evaluate the effectiveness
and safety of a combination therapy involving metformin, teneligliptin, and
glimepiride in patients diagnosed with T2DM.

Methods:
The present quasi-experimental clinical trial involved 300 adult T2DM patients. They
were divided into three groups: Group 1 (Metformin; n=100), Group 2 (Metformin + Teneligliptin;
n=100), and Group 3 (Metformin + Teneligliptin +; n=100). Along with demographic
data, we collected information on HbA1c, FBS, and PPBS levels, as well as fasting insulin, CPeptide,
HOMA-IR, QUICKI-IR, and lipid, renal, and hepatic profiles at baseline and after 3, 6,
and 12 months. Data analysis was performed using SPSS 21.0 software.

Results:
A total of 300 patients participated in the study. At the end of 12 months, triple-drug
therapy achieved significant glycemic control (HbA1c: 6.56±0.50%; P<0.0001) and reduced
FBS (7.6±1.41 mg/dl; P<0.0001), PPBS (9.39±2.14 mg/dl; P<0.0001), and fasting insulin
(11.26±2.5 IU; P<0.0001), C-peptide (2.01±2.29 ng/ml; P<0.0001), and insulin resistance by
HOMA-IR (3.74±0.7; P<0.0001). Favorable lipid profiles (P<0.0001) were noted versus other
groups. Despite renal and hepatic profile variations, values remained within the normal range.

Conclusion:
The combination of teneligliptin with metformin and glimepiride in T2DM patients
demonstrated significant improvements in glycaemic control, reduced insulin resistance, and
positive effects on lipid, renal, and hepatic profiles. Importantly, the therapy did not result in serious
adverse drug reactions, such as hypoglycemia. We need more RCTs to substantiate these
findings.
Composition and dynamics of bladder, vaginal and bowel microbiota during three trimesters in healthy pregnant women
Authors: Naboka Yu. L. , Vorobyeva N. V. , Gudima I. A. , Sinyavskaya T. G. , Ismailov R. S. , Naber K. G. , Kogan M. I. 
Published: December 2024

Introduction. The microbiota dynamics of the core biotopes during pregnancy are hardly studied, although changes in these compartments have an important role in both the functioning of the female organism and foetal development.Objective. To study the dynamics and interactions of changes in bladder, vaginal and bowel microbiota in healthy pregnant women over three trimesters (TRI-1, 2, 3).Materials & Methods. Study design: a single-centre comparative observational longitudinal study. Thirty out of first-time 220 pregnant women were selected for screening at the antenatal clinic from 2021 to 2022. All pregnant women underwent sampling at T-1, 2, 3: mid-stream bladder urine samples, posterior vaginal swabs and faecal masses were collected for culture study. After a special pre-culture preparation, samples were examined on an expanded set of nutrient media (n = 13) using special cultivation (aerobic-anaerobic) conditions. Based on the research results, identification frequencies (IDFs), microbial load values (MLVs) and microbial co-occurrence coefficients between the different biotopes were estimated.Results. Culture study revealed various bacteria in each biotope investigated during all TRIs. In the urine, aerobes and anaerobes were observed from TRI-1 to TRI-3 with different IDFs, but no taxa showed a stable IDFs. In the vagina, IDFs of bacteria were similar to urinary. The bowel microbiota was the most stable biotope remained almost unchanged during pregnancy. In the urine and vagina, mean MLVs of most aerobes and anaerobes did not change significantly throughout pregnancy. In the bowel, MLVs were consistently higher than in the urine and vaginal swabs. According to the co-occurrence analysis bladder-vagina and bladder-bowel biotopes showed significantly more interconnections between microorganisms in all TRIs.Conclusion. The observed microbiota structure during all TRIs is associated with uncomplicated gestation. These results will be valuable for studying changes of microbiota in complicated pregnancies.
Assessment of novel biomarkers of renal dysfunction associated with lower urinary tract symptoms in men with benign prostatic hyperplasia
Authors: Startsev V. Yu. , Dudarev V. A. 
Published: December 2024

Introduction. The problem of diagnostics and treatment of patients with complex lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) remains highly relevant. Clinical diagnostic methods do not always allow timely prediction of changes in renal, upper and lower urinary tract function with different types of treatment intervention. The search for potential biomarkers allowing minimally invasive assessment of the bladder and renal function condition seems to be a promising direction of scientific research.Objective. To identify potential urine and serum biomarkers allowing to assess renal function in patients with LUTS/BPH.Materials & methods. The study included 69 patients with LUTS/BPH and subsequently divided them into two groups. Group 1 included 48 patients with moderate LUTS who received combination therapy with alpha-1 adrenergic blockers (AABs) and 5-alpha reductase inhibitors (5ARIs). Group 2 included 21 patients with severe LUTS/BPH. Patients of group 2 underwent surgical treatment: transurethral resection of the prostate. In addition to standard research methods (IPSS, voiding diaries, laboratory, urodynamic and radiation techniques), to search for potential biomarkers in serum and urine, concentrations of: insulin-like growth factor binding protein-7 (IGFBP7), B-Cross Laps, Cystatin C, OPN, trefoil factor (TFF3), uromodulin, Clusterin, lactate dehydrogenase (LDH). The follow-up period for patients was 12 months.Results. The study noted that IGFBP7, Cystatin C, TFF3 in the blood serum, as well as LDH, Clusterin in the urine are associated with the severity of LUTS/BPH. Serum biomarker levels were initially higher in patients with severe LUTS compared to patients with moderate LUTS (group 1). The levels of these substrates decreased in patients of all groups during treatment (conservative therapy, surgical interventions for BPH). When assessing urinary biomarkers, the greatest decrease in Clusterin level by the end of follow-up was registered in group 1 patients, the least pronounced in group 2 patients. The initial value of LDH was twice higher in group 2 vs group 1 and progressively decreased after surgical treatment of bladder outlet obstruction.Conclusion. Biomarkers used to assess renal dysfunction in the development of LUTS/BPH are a promising area of scientific research. Panels of new markers will enable to predict renal dysfunction in patients with moderate-to-severe LUTS, which will improve the quality of medical care for this category of patients.
Germ cell tumour of an undescended testis diagnosed in a patient with bilateral cryptorchidism presenting both male and female primary sex characteristics
Authors: Petrov S. B. , Arnautov A. V. , Nikulina K. A. , Reva S. A. , Tsaregorodtseva A. D. , Tikhonova Yu. A. 
Published: December 2024

Introduction. Testicular germ cell tumor (GCT) is a rare pathology that accounts for about 1% of all malignant neoplasms in men, while cryptorchidism is one of the main risk factors. We present a clinical case of a GCT of an undescended testicle in patient with bilateral cryptorchidism and male to female sexual characteristics.Objective. To present a rare clinical case of testicular GCT in a patient with disorder of sex development (DSD).Clinical case. A 32-year-old patient with a history of bilateral cryptorchidism with a large neoplasm of the right undescended testis was detected during examination at the Department of Andrology and Oncourology No. 6 of the Pavlov State Medical University. Based on MRI scans, a cavity formation interpreted as an enlarged left seminal vesicle was fixed to the lower pole of the right testicle. Bilateral removal of the left and right testicles (tumour-affected) was performed. The seminal duct was detected from the lower pole of the formation, passing into a blindly ending soft tissue cavity formation (in shape and structure resembling a uterus) — its removal was performed. Histological examination showed that the neoplasm was a typical seminoma of the right testicle, pT2. The soft tissue cavity was represented by a rudimentary uterus with fallopian tubes. Adjuvant chemotherapy was performed.Conclusion. We demonstrate a rare clinical case of a GCT of the undescended testis in a patient with bilateral cryptorchidism, DSD (46, XY), and Müllerian duct persistence syndrome. These nosologies require early diagnosis and treatment.
Chinese Clinical Named Entity Recognition With Segmentation Synonym Sentence Synthesis Mechanism: Algorithm Development and Validation
Authors: Tang Jian , Huang Zikun , Xu Hongzhen , Zhang Hao , Huang Hailing , Tang Minqiong , Luo Pengsheng , Qin Dong 
Published: December 2024

Abstract

Background
Clinical named entity recognition (CNER) is a fundamental task in natural language processing used to extract named entities from electronic medical record texts. In recent years, with the continuous development of machine learning, deep learning models have replaced traditional machine learning and template-based methods, becoming widely applied in the CNER field. However, due to the complexity of clinical texts, the diversity and large quantity of named entity types, and the unclear boundaries between different entities, existing advanced methods rely to some extent on annotated databases and the scale of embedded dictionaries.

Objective
This study aims to address the issues of data scarcity and labeling difficulties in CNER tasks by proposing a dataset augmentation algorithm based on proximity word calculation.

Methods
We propose a Segmentation Synonym Sentence Synthesis (SSSS) algorithm based on neighboring vocabulary, which leverages existing public knowledge without the need for manual expansion of specialized domain dictionaries. Through lexical segmentation, the algorithm replaces new synonymous vocabulary by recombining from vast natural language data, achieving nearby expansion expressions of the dataset. We applied the SSSS algorithm to the Robustly Optimized Bidirectional Encoder Representations from Transformers Pretraining Approach (RoBERTa) + conditional random field (CRF) and RoBERTa + Bidirectional Long Short-Term Memory (BiLSTM) + CRF models and evaluated our models (SSSS + RoBERTa + CRF; SSSS + RoBERTa + BiLSTM + CRF) on the China Conference on Knowledge Graph and Semantic Computing (CCKS) 2017 and 2019 datasets.

Results
Our experiments demonstrated that the models SSSS + RoBERTa + CRF and SSSS + RoBERTa + BiLSTM + CRF achieved F1-scores of 91.30% and 91.35% on the CCKS-2017 dataset, respectively. They also achieved F1-scores of 83.21% and 83.01% on the CCKS-2019 dataset, respectively.

Conclusions
The experimental results indicated that our proposed method successfully expanded the dataset and remarkably improved the performance of the model, effectively addressing the challenges of data acquisition, annotation difficulties, and insufficient model generalization performance.
One-Pot Synthesis and <i>In Vitro</i> Studies of Calix[4]-2-methylresorcinarene Derivatives as Antimalarial Agents Against <i>Plasmodium falciparum</i> Chloroquine-Resistant Strain FCR-3
Authors: Nursofia Baiq Ike , Kurniawan Yehezkiel Steven , Jumina Jumina , Pranowo Harno Dwi , Sholikhah Eti Nurwening , Julianus Jeffry , Wibowo Susalit Setya , Fatimi Hana Anisa , Priastomo Yoga , Priyangga Krisfian Tata Aneka 
Published: December 2024

Malaria is an endemic disease in Indonesia caused by infection from the Plasmodium parasite. Recently, antimalarial resistance significantly contributed to the decline in the cure rate of malaria sufferers. In this work, three calix[4]resorcinarenes have been synthesized from 2-methylresorcinol and different benzaldehyde derivatives, i.e., 4-chlorobenzaldehyde, 4-methoxybenzaldehyde, and 4-dimethylaminobenzaldehyde through the one-pot synthesis procedure. The calix[4]resorcinarenes synthesis was done through a cyclo-condensation reaction by using HCl 37% as the catalyst and ethanol as the solvent in an one-pot reaction. The structures of the synthesized products were confirmed using Fourier transform infrared, proton-nuclear magnetic resonance, and liquid chromatography-mass spectrometry techniques. The antimalarial activity assay was evaluated against the Plasmodium falciparum FCR-3 strain through an in vitro study. Three synthesized compounds, i.e., C-4-chlorophenylcalix[4]-2-methylresorcinarene, C-4-methoxyphenylcalix[4]-2-methylresorcinarene and C-4-dimethylaminophenylcalix[4]-2-methylresorcinarene have been successfully synthesized in up to 97% yield. The C-4-chlorophenylcalix[4]-2-methylresorcinerene exhibited the most potent antimalarial activity with a half-maximal inhibitory concentration (IC50) value of 2.66 µM against P. falciparum FCR-3 while the C-4-methoxyphenylcalix[4]-2-methylresorcinarene and C-4-dimethylaminophenylcalix[4]-2-methylresorcinarene gave the IC50 values of 23.63 and 13.82 µM, respectively. From the results, it could be concluded that the antimalarial activity of calix[4]-2-methylresorcinarenes was influenced by the type of substituent of aromatic rings at the para position.
Analisis Pemasaran dan Pendapatan Pedagang Sapi PO Kebumen Siap Potong di Pasar Hewan Argopeni Kecamatan Kebumen Kabupaten Kebumen
Authors: Ismawatun Ismawatun , Nuraeni Nunur 
Published: December 2024

Latar Belakang: Penelitian ini untuk mengetahui pendapatan pedagang Sapi PO Kebumen siap potong dan alur pemasarannya di Pasar Argopeni Kecamatan Kebumen Kabupaten Kebumen. Tujuan: Penelitian ini bertujuan untuk mengetahui presentase penjualan Sapi PO Kebumen siap potong yang menggunakan jasa blantik dan tanpa blantik di Pasar Hewan Argopeni Kabupaten Kebumen, mengetahui besarnya pendapatan pedagang Sapi PO Kebumen siap potong di Pasar Hewan Argopeni Kabupaten Kebumen, dan untuk mengetahui pengaruh profil pedagang Sapi PO Kebumen siap potong sebagai variabel bebas yang terdiri dari umur, pengalaman dan pendidikan terhadap pendapatan sebagai varibel terikat. Metode: Penelitian ini merupakan penelitian deskriptif dengan menggunakan motode survey menggunakan instrumen kuesioner dalam pengambilan data. Teknik pengambilan sampel dalam penelitian ini menggunakan sensus dimana sampel pedagang Sapi PO Kebumen siap potong sebanyak 10 orang. Teknik analisis data yang digunakan untuk menguji hipotesis adalah analisis regresi linear berganda. Hasil: Hasil analisis variansi menunjukan bahwa varibel umur, pengalaman dan pendidikan berpengaruh nyata (P>0,05) terhadap pendapatan pedagang Sapi PO Kebumen siap potong. Saluran pemasaran Sapi PO Kebumen siap potong di Pasar Hewan Argopeni yang menggunakan jasa blantik sebesar 92% dan yang tanpa blantik sebesar 8%. Pendapatan rata-rata pedagang Sapi PO Kebumen siap potong di Pasar Hewan Argopeni Kebumen adalah sebesar Rp.28.002.000,-/bulan. Berdasarkan nilai Multiple R 0,844 menunjukan bahwa terdapat korelasi yang sangat kuat antara umur, pengalaman dan pendidikan dengan pendapatan. Kesimpulan: Berdasarkan hasil penelitian dapat disimpulkan bahwa umur, pengalaman, dan pendidikan secara simultan terdapat korelasi terhadap pendapatan pedagang Sapi PO Kebumen siap potong di Pasar Hewan Argopeni.
Room Ambience: Home as Heard in Film and Media Arts
Authors: Budhaditya Chattopadhyay  
Published: December 2024

The article investigates the mediation of homey ambiences or domestic atmospheres and their relation to the outdoors in film and media productions. The article examines how human mediation impacts the perception of site-specific ambient sounds of the home that are aesthetically deployed as auditory backdrops in films and media artworks. The focus is on examining the processes of reconstructing the site of the home through the reproduction, mediation, and rendering of the relatively closed and private indoor sonic environment and its complex relationship to the public outdoors.
KEWIRAUSAHAAN BERBASIS SUMBER DAYA ALAM UNTUK PENGUATAN EKONOMI MASYARAKAT
Authors: Delfiana Sasmitha , Anastasya Soraya 
Published: December 2024

Kewirausahaan berperan penting dalam mendukung pertumbuhan ekonomi suatu bangsa. Penelitian ini bertujuan untuk menganalisis potensi kewirausahaan berbasis sumber daya alam (SDA) dalam meningkatkan kesejahteraan ekonomi masyarakat lokal. Metode penelitian yang digunakan adalah pendekatan deskriptif kualitatif dengan teknik pengumpulan data berupa wawancara, observasi, dan studi dokumentasi. Analisis data dilakukan melalui proses reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa kewirausahaan berbasis SDA memiliki dampak signifikan terhadap peningkatan ekonomi daerah. Temuan utama meliputi: (1) kewirausahaan berbasis SDA membuka peluang kerja baru bagi masyarakat lokal, dan (2) memberikan ruang bagi wirausahawan untuk mengembangkan ide usaha secara kreatif dan inovatif, khususnya melalui diversifikasi produk berbasis potensi SDA setempat. Pendekatan ini dapat menjadi model penguatan ekonomi berbasis komunitas yang berkelanjutan. Kata Kunci: kewirausahaan, sumber daya alam, ekonomi, masyarakat
Ullóa, Sergio Valerio (2021). Santa Ana Acatlán. De la desamortización a la dotación de tierras. Una historia sin despojos. Guadalajara: Universidad de Guadalajara. Centro Universitario de Ciencias Sociales y Humanidades, 312 pp.
Authors: Isais Contreras Miguel Angel 
Published: December 2024

Reseña crítica del libro Santa Ana Acatlán. De la desamortización a la dotación de tierras. Una historia sin despojos, de Valerio Ullóa, Sergio, Guadalajara, Universidad de Guadalajara, Centro Universitario de Ciencias Sociales y Humanidades, 2021, 312 páginas.
Internalization of Early Childhood Responsibility Character Values Through Physical Education
Authors: Loka Novita , Sari Novita 
Published: December 2024

Anak usia dini merupakan individu yang mengalami proses pertumbuhan dan perkembangan yang sangat pesat, bahkan dikatakan merupakan suatu lompatan perkembangan. Anak usia dini mempunyai rentang usia yang sangat berharga dibandingkan usia selanjutnya, karena perkembangan kecerdasannya sangat luar biasa. Penanaman karakter harus dilakukan sejak dini, agar karakter tertanam kuat dalam diri anak hingga dewasa. Usia dini merupakan masa kritis dalam pembentukan karakter. Penelitian ini bertujuan untuk memberikan informasi tentang penanaman karakter tanggung jawab pada anak usia dini melalui aktivitas fisik. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kualitatif dengan pengumpul data berdasarkan observasi, wawancara dan dokumentasi yang didapatkan di lingkungan TK Sekolah Alam Indralaya Utara. Analisa data yang dilakukan melalui pendekatan Miles dan Huberman melalui pengumpulan data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa aktivitas jasmani sangat efektif dan solusi dalam menanamkan karakter tanggung jawab pada anak adalah melalui pendidikan jasmani dengan menerapkan langsung pada anak, pendekatan yang baik kepada anak dan melakukan perbaikan serta mengulanginya. Adapun keterbatasan penelitian ini berfokus pada penanaman karakter pada anak usia dini melalui pembelajaran fisik anak usia dini.
Early childhood is an individual who experiences a very rapid process of growth and development, even said to be a developmental leap. Early childhood has a very valuable age range compared to later ages because the development of intelligence is very extraordinary. Character cultivation must be carried out from an early age so that character is firmly embedded in children until adulthood. Early childhood is a critical period in character formation. This research aims to provide information about the cultivation of responsibility in early childhood through physical activity. The research method used in this study is a qualitative research method with data collectors based on observations, interviews, and documentation obtained in the kindergarten environment of North Indralaya Nature School. Data analysis is carried out through the Miles and Huberman approach through data collection, data presentation, and conclusions drawn. The results of the study show that physical activities are very effective, and the solution to instilling the character of responsibility in children is through physical education by applying a good approach to children, making improvements, and repeating them. The limitations of this study focus on instilling character in early childhood through early childhood physical learning.