bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coal-mine fire-related fine particulate matter and medical-service utilization in Australia: a time-series analysis from the Hazelwood Health Study
Authors: Johnson Amanda L , Gao Caroline X , Dennekamp Martine , Williamson Grant J , Carroll Matthew T C , Dimitriadis Christina , Dipnall Joanna F , Ikin Jillian F , Johnston Fay H , McFarlane Alexander C , Sim Malcolm R , Stub Dion A , Abramson Michael J , Guo Yuming 
Published: October 2019

Abstract

Background
This study assessed the association between coal-mine-fire-related fine particulate matter (PM2.5) and medical-service utilization, following a 6-week coal-mine fire in Australia, in 2014. Areas in the immediate vicinity of the mine experienced hourly mine-fire-related PM2.5 concentrations of up to 3700 μg/m3.

Methods
Data on medical-service utilization were collected from the Medicare Benefits Schedule—a national database of payment for medical services. PM2.5 concentrations were modelled using atmospheric chemical transport modelling. Quasi-Poisson interrupted distributed lag time-series analysis examined the association between daily mine-fire-related PM2.5 concentrations and medical-service utilization, including General Practitioner (GP) consultations and respiratory, cardiovascular and mental health services. Confounders included seasonality, long-term trend, day of the week, maximum daily temperature and public holidays. Gender and age stratification were conducted.

Results
A 10-μg/m3 increase in PM2.5 was associated with an increased relative risk of service usage for all long and short GP consultations [11% (95% confidence interval: 7 to 15%)] and respiratory services [22% (4 to 43%)] in both men and women. Sex stratification found an increased relative risk in mental health consultations in men [32% (2 to 72%)] but not women. No associations were found for cardiovascular services in men or women.

Conclusions
Coal-mine-fire-related PM2.5 exposure was associated with increased use of medical services for GP consultations and respiratory services in men and women and mental health consultations in men. These findings can inform the development of future public-health-policy responses in the event of major air-pollution episodes.
Informed and uninformed empirical therapy policies
Authors: Houy Nicolas , Flaig Julien 
Published: October 2019

Abstract
We argue that a proper distinction must be made between informed and uninformed decision making when setting empirical therapy policies, as this allows one to estimate the value of gathering more information about the pathogens and their transmission and thus to set research priorities. We rely on the stochastic version of a compartmental model to describe the spread of an infecting organism in a health care facility and the emergence and spread of resistance to two drugs. We focus on information and uncertainty regarding the parameters of this model. We consider a family of adaptive empirical therapy policies. In the uninformed setting, the best adaptive policy allowsone to reduce the average cumulative infected patient days over 2 years by 39.3% (95% confidence interval (CI), 30.3–48.1%) compared to the combination therapy. Choosing empirical therapy policies while knowing the exact parameter values allows one to further decrease the cumulative infected patient days by 3.9% (95% CI, 2.1–5.8%) on average. In our setting, the benefit of perfect information might be offset by increased drug consumption.
A Sharp Rearrangement Principle in Fourier Space and Symmetry Results for PDEs with Arbitrary Order
Authors: Lenzmann Enno , Sok Jérémy 
Published: October 2019

Abstract
We prove sharp inequalities for the symmetric-decreasing rearrangement in Fourier space of functions in $\mathbb{R}^d$. Our main result can be applied to a general class of (pseudo-)differential operators in $\mathbb{R}^d$ of arbitrary order with radial Fourier multipliers. For example, we can take any positive power of the Laplacian $(-\Delta )^s$ with $s&gt; 0$ and, in particular, any polyharmonic operator $(-\Delta )^m$ with integer $m \geqslant 1$. As applications, we prove radial symmetry and real-valuedness (up to trivial symmetries) of optimizers for (1) Gagliardo–Nirenberg inequalities with derivatives of arbitrary order, (2) ground states for bi- and polyharmonic nonlinear Schrödinger equations (NLS), and (3) Adams–Moser–Trudinger type inequalities for $H^{d/2}(\mathbb{R}^d)$ in any dimension $d \geqslant 1$. As a technical key result, we solve a phase retrieval problem for the Fourier transform in $\mathbb{R}^d$. To achieve this, we classify the case of equality in the corresponding Hardy–Littlewood majorant problem for the Fourier transform in $\mathbb{R}^d$.
A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection
Authors: Mire Chad E , Chan Yee-Peng , Borisevich Viktoriya , Cross Robert W , Yan Lianying , Agans Krystle N , Dang Ha V , Veesler David , Fenton Karla A , Geisbert Thomas W , Broder Christopher C 
Published: October 2019

Abstract

Background
Nipah virus (NiV) and Hendra virus (HeV) are zoonotic paramyxoviruses that cause severe disease in both animals and humans. There are no approved vaccines or treatments for use in humans; however, therapeutic treatment of both NiV and HeV infection in ferrets and non-human primates with a cross-reactive, neutralizing human monoclonal antibody (mAb), m102.4, targeting the G glycoprotein has been demonstrated. In a previous study, we isolated, characterized, and humanized a cross-reactive, neutralizing anti-F mAb (h5B3.1). The mAb h5B3.1 blocks the required F conformational change needed to facilitate membrane fusion and virus infection, and the epitope recognized by h5B3.1 has been structurally defined; however, the efficacy of h5B3.1 in vivo is unknown.

Methods
The post-infection antiviral activity of h5B3.1 was evaluated in vivo by administration in ferrets after NiV and HeV virus challenge.

Results
All subjects that received h5B3.1 from 1 to several days after infection with a high-dose, oral-nasal virus challenge were protected from disease, whereas all controls died.

Conclusions
This is the first successful post-exposure antibody therapy for NiV and HeV using a humanized cross-reactive mAb targeting the F glycoprotein, and the findings suggest that a combination therapy targeting both F and G should be evaluated as a therapy for NiV/HeV infection.
Moving Global IR Forward—A Road Map
Authors: Gelardi Maiken 
Published: October 2019

AbstractMany disciplinary analyses have exposed international realtions (IR) as a Western-centric discipline, unaware of or unconcerned with its own ethnocentric outlook. A growing consensus in the global IR framework argues that it is time to move beyond disciplinary critique, but scholars disagree on how to proceed. Three key issues are still being debated: who can speak, how to go local, and how to make the local global. This article confronts these questions by offering three interlinked contributions. First, it develops a typology of scholarly profiles by combining the typically isolated debates on scholarly origin, embeddedness within local context, and location. Second, the article identifies three main strategies for discovering and developing theories outside the core. Third, it offers four different avenues for applying local theories to the larger global canvas, underlining that Global South theories should not necessarily be limited to their “own” regions. Together these three contributions constitute a comprehensive roadmap for how to advance global IR's research agenda. The article provides examples focused on Latin America, highlighting the benefits of the roadmap while also giving agency to regional theoretical debates that are often overlooked in the Global IR debate.
User-focused data sharing agreements: a foundation for the genomic future
Authors: Petersen Carolyn 
Published: October 2019

AbstractData sharing agreements that clearly describe what individuals are agreeing to and what responsibilities data stewards will undertake are crucial for the establishment, maintenance, and flourishing of genomic datasets. To optimize genomic data resources, researchers, care professionals, and informaticians must regard system design, user objectives, and environmental considerations through users’ eyes, identifying fundamental values on which to build and potential barriers to success that must be avoided. Design of agreements that promote desired data sharing and protect valuable data resources as necessary begins with a review of user interests and concerns. Nontraditional approaches for informed consent (eg, abbreviated informed consent, electronic informed consent, and dynamic consent) can facilitate achievement of data donors’ privacy-related goals while making data available to researchers. Transparency in individual-researcher interactions, recognition and accommodation of cultural differences, and identification of shared needs and goals create a foundation for data sharing agreements that work over short and long terms.
MiRNA-96-5p contributed to the proliferation of gastric cancer cells by targeting FOXO3
Authors: He Xionghui , Zou Kejian 
Published: October 2019

Abstract
Various microRNAs (miRNAs, miRs) and the forkhead box O (FOXO) family proteins have been shown to influence gastric cancer progression and development. Here, we aimed to identify the gastric cancer related miRNAs and their relationship with the FOXO family. MiRNA profiles were generated by miRNA microarray screening from pre-operative plasma samples. Quantitative reverse transcription PCR and western bolt were used to determine the expression levels of miR-96 and FOXO family. 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide assay and colony formation assay were used to test the cell viability. The miR-96-5p and FOXO3 interaction were confirmed by luciferase reporter assay. Our results demonstrated the excessive expression of miR-96-5p in gastric cancer cell lines and plasma samples from gastric cancer patients. In addition, the protein levels of FOXO3 were decreased in tissue samples from gastric cancer patients. Moreover, miR-96-5p accelerated the gastric cancer cell proliferation by directly targeting FOXO3. Therefore, we conclude that iR-96-5p might promote the progression of gastric cancer by directly targeting FOXO3 mRNA and downregulating the expression of FOXO3 protein, which provides new insights for the molecular mechanism of gastric cancer.
The Autophagy-Related Protein GABARAP Is Induced during Overwintering in the Bean Bug (Hemiptera: Alydidae)
Authors: Tachibana Shin-Ichiro , Matsuzaki Shinji , Tanaka Masako , Shiota Masayuki , Motooka Daisuke , Nakamura Shota , Goto Shin G 
Published: October 2019

Abstract
In most insects dependent on food resources that deplete seasonally, mechanisms exist to protect against starvation. Insects overcome periods of food depletion using diapause-associated physiological mechanisms, such as increased energy resources in fat bodies and suppression of metabolism. Because autophagy supplies energy resources through the degradation of intracellular components, we hypothesized that it might be an additional strategy to combat starvation during overwintering. In this study, we measured the abundance of the proteins involved in the signaling pathway of autophagy during overwintering in adults of the bean bug Riptortus pedestris (Fabricius) (Hemiptera: Alydidae), which must withstand the periodic depletion of its host plants from late fall to early spring. Although the levels of gamma-aminobutyric acid receptor-associated protein (GABARAP) markedly increased after the cessation of food supply, AMP-activated protein kinase (AMPK) and target of rapamycin (TOR) were not found to be associated with food depletion. Thus, food depletion appears to induce autophagy independent of AMPK and TOR. The GABARAP levels significantly increased universally when the food supply ceased, irrespective of the diapause status of adults and low-temperature conditions. In overwintering diapause adults under seminatural conditions, the GABARAP levels significantly increased during early spring. Thus, autophagy appears to assist the survival of the bean bugs under natural conditions of food deficiency.
Toward a Geoeconomic Order in International Trade and Investment
Authors: Roberts Anthea , Choer Moraes Henrique , Ferguson Victor 
Published: October 2019

Abstract
Recent developments suggest that the international economic order is transitioning away from the Neoliberal Order that has flourished for much of the post-Cold War period toward a new Geoeconomic Order. The shift to this new order, which is characterized by a growing ‘securitisation of economic policy and economisation of strategic policy’, will likely see the rules, norms, and institutions of international trade and investment law undergoing significant change. We expose the differences in the underlying logic of these orders, explore how this shift is being driven by the emerging USA–China tech/trade war, and consider the consequences of this transition for global economic governance.
Scientific Practice in Modeling Diseases: Stances from Cancer Research and Neuropsychiatry
Authors: Bertolaso Marta , Campaner Raffaella 
Published: October 2019

AbstractIn the last few decades, philosophy of science has increasingly focused on multilevel models and causal mechanistic explanations to account for complex biological phenomena. On the one hand, biological and biomedical works make extensive use of mechanistic concepts; on the other hand, philosophers have analyzed an increasing range of examples taken from different domains in the life sciences to test—support or criticize—the adequacy of mechanistic accounts. The article highlights some challenges in the elaboration of mechanistic explanations with a focus on cancer research and neuropsychiatry. It jointly considers fields, which are usually dealt with separately, and keeps a close eye on scientific practice. The article has a twofold aim. First, it shows that identification of the explananda is a key issue when looking at dynamic processes and their implications in medical research and clinical practice. Second, it discusses the relevance of organizational accounts of mechanisms, and questions whether thorough self-sustaining mechanistic explanations can actually be provided when addressing cancer and psychiatric diseases. While acknowledging the merits of the wide ongoing debate on mechanistic models, the article challenges the mechanistic approach to explanation by discussing, in particular, explanatory and conceptual terms in the light of stances from medical cases.
Metastatic melanoma of the gallbladder presenting as polyp in acute cholecystitis
Authors: Saraswat Nirvana B , DeVoe William B 
Published: October 2019

Abstract
Malignant melanoma is an aggressive neural crest cell-derived neoplasm with a propensity for metastasis to almost any organ. Gastrointestinal metastasis may manifest as gallbladder polyps. We report a case of metastatic malignant melanoma diagnosed in an 81-year-old male after cholecystectomy performed for acute cholecystitis. Cholecystectomy remains the standard of care for treatment of isolated gallbladder metastasis, especially in the setting of symptomatic disease. Mutation-directed chemotherapeutic and immunotherapeutic modalities serve as efficacious adjunctive therapy in addition to primary surgical resection for this rare condition.
Endophytes alleviate the elevated CO2-dependent decrease in photosynthesis in rice, particularly under nitrogen limitation
Authors: Rho Hyungmin , Doty Sharon Lafferty , Kim Soo-Hyung 
Published: October 2019

Abstract
The positive effects of high atmospheric CO2 concentrations [CO2] decrease over time in most C3 plants because of down-regulation of photosynthesis. A notable exception to this trend is plants hosting N-fixing bacteria. The decrease in photosynthetic capacity associated with an extended exposure to high [CO2] was therefore studied in non-nodulating rice that can establish endophytic interactions. Rice plants were inoculated with diazotrophic endophytes isolated from the Salicaceae and CO2 response curves of photosynthesis were determined in the absence or presence of endophytes at the panicle initiation stage. Non-inoculated plants grown under elevated [CO2] showed a down-regulation of photosynthesis compared to those grown under ambient [CO2]. In contrast, the endophyte-inoculated plants did not show a decrease in photosynthesis associated with high [CO2], and they exhibited higher photosynthetic electron transport and mesophyll conductance rates than non-inoculated plants under high [CO2]. The endophyte-dependent alleviation of decreases in photosynthesis under high [CO2] led to an increase in water-use efficiency. These effects were most pronounced when the N supply was limited. The results suggest that inoculation with N-fixing endophytes could be an effective means of improving plant growth under high [CO2] by alleviating N limitations.
Isavuconazole for the treatment of patients with invasive fungal diseases involving the central nervous system
Authors: Schwartz Stefan , Cornely Oliver A , Hamed Kamal , Marty Francisco M , Maertens Johan , Rahav Galia , Herbrecht Raoul , Heinz Werner J 
Published: October 2019

Abstract
The incidence of invasive fungal diseases (IFDs) with central nervous system (CNS) involvement is increasing due to the rising numbers of immunocompromised individuals, such as patients receiving chemotherapy, transplantation procedures, or immune-modulating therapies. CNS IFDs cause significant morbidity and mortality, and treatments are complicated by difficulties in identifying fungal pathogens and delivering antifungal agents to the CNS. Isavuconazole is a novel triazole with broad-spectrum activity that has shown good blood–brain barrier penetration in animal models. We present a retrospective analysis of isavuconazole in the treatment of patients with CNS IFDs and who either participated in the phase III VITAL or SECURE clinical trials, or were included in a named-patient program. A total of 36 patients were identified, including 27 patients from the clinical trials. Of these patients, 47.2% had hematologic malignancies, while 13.9% had no identifiable underlying conditions. Mucorales, Aspergillus species, and Cryptococcus species accounted for 30.6%, 22.2%, and 13.9% of infections, respectively. The overall survival rate was 80.6% at day 42 and 69.4% at day 84, and at the end of treatment, a complete or partial clinical response was achieved in 58.3% of patients. Isavuconazole exhibited clinical activity in a variety of CNS IFDs.
A resistive extension for ideal magnetohydrodynamics
Authors: Wright Alex James , Hawke Ian 
Published: October 2019

ABSTRACT
We present an extension to the special relativistic, ideal magnetohydrodynamic (MHD) equations, designed to capture effects due to resistivity. The extension takes the simple form of an additional source term that, when implemented numerically, is shown to emulate the behaviour produced by a fully resistive MHD description for a range of initial data. The extension is developed from first principles arguments, and thus requires no fine-tuning of parameters, meaning it can be applied to a wide range of dynamical systems. Furthermore, our extension does not suffer from the same stiffness issues arising in resistive MHD, and thus can be evolved quickly using explicit methods, with performance benefits of roughly an order of magnitude compared to current methods.
Dark matter heating of gas accreting onto Sgr A*
Authors: Bennewitz Elizabeth R , Gaidau Cristian , Baumgarte Thomas W , Shapiro Stuart L 
Published: October 2019

ABSTRACT
We study effects of heating by dark matter (DM) annihilation on black hole gas accretion. We observe that, for reasonable assumptions about DM densities in spikes around supermassive black holes, as well as DM masses and annihilation cross-sections within the standard WIMP model, heating by DM annihilation may have an appreciable effect on the accretion on to Sgr A* in the Galactic Centre. Motivated by this observation we study the effects of such heating on Bondi accretion, i.e. spherically symmetric, steady-state Newtonian accretion on to a black hole. We consider different adiabatic indices for the gas, and different power-law exponents for the DM density profile. We find that typical transonic solutions with heating have a significantly reduced accretion rate. However, for many plausible parameters, transonic solutions do not exist, suggesting a breakdown of the underlying assumptions of steady-state Bondi accretion. Our findings indicate that heating by DM annihilation may play an important role in the accretion onto supermassive black holes at the centre of galaxies, and may help explain the low accretion rate observed for Sgr A*.
The inner view of NGC 1052 using multiple X-ray observations
Authors: Osorio-Clavijo N , González-Martín O , Papadakis I E , Masegosa J , Hernández-García L 
Published: October 2019

ABSTRACT
In this paper, we present a multi-epoch analysis of NGC 1052, a prototypical low-luminisity active galactic nucleus, using XMM–Newton, Suzaku and NuSTAR observations taken from 2001 to 2017. This is the first time that results from NuSTAR observations have been reported for NGC 1052. Regarding technical aspects, we found a wavelength-dependent calibration issue between simultaneous XMM–Newton and NuSTAR spectra, characterized by a change in the photon index of $\rm { \Gamma _{NuSTAR}- \Gamma _{XMM-Newton}=0.17\pm 0.04}$. We use ancillary Chandra data to decontaminate the nuclear spectrum from circumnuclear contributors. We find that two baseline models can fit the broad (0.5–50 keV) X-ray spectrum of the source. One consists of a power-law-like continuum that is absorbed by a uniform absorber, and is reflected by neutral material, and a separate power-law component in the soft band. The second model consists of a clumpy absorber. The reflection component is still present, but not the soft-band power law. Instead, absorption by a warm absorber is necessary to fit the spectra. This is the first time that a reflection component has been established in this object, thanks to high-energy data from NuSTAR. This component is constant in flux and shape, supporting the idea that it is produced away from the central source (probably in the torus). We find flux, spectral slope and absorption variations on time-scales of months to years. We also find that a patchy absorber can explain the behaviour of this source better, as it is ∼200 times more likely than the uniform absorber and yields smaller intrinsic variations.