bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incomplete Ear Amputation
Authors: Zhang Chao , Teng Li , Xu Jia-Jie , Lu Jian-Jian , Xie Fang , Yang Li-Ya , Li Shu-Yuan , Wu Huan-Huan , Sun Heng , Yang Biao 
Published: October 2018

Abstract
Ear amputations are common in emergency departments as the auricle's protrusion from the lateral aspect of the head makes it particularly susceptible to trauma. Of the numerous approaches for auricle injuries, the classic methods include microsurgical replantation, primary reattachment, composite graft, retroauricular pocket principle,
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secondary reconstruction with rib cartilage, and methods using postauricular flap. The success of the operation depends largely on choosing the appropriate surgical procedure since many factors can influence surgical outcome. There is no 1 gold standard technique to treat the variety of auricle injuries. Inappropriate choice of surgical approach can be detrimental to subsequent reconstructive surgery. Therefore, the initial choice of optimal surgical approach is particularly important. In this article, a rare report of left subtotal ear laceration with inferior lobule pedicle by nonmicrosurgical primary reattachment was presented. The operation obtained an ideal cosmetic effect.
Constitutional democracy and technology in the age of artificial intelligence
Authors: Nemitz Paul 
Published: October 2018

Given the foreseeable pervasiveness of artificial intelligence (AI) in modern societies, it is legitimate and necessary to ask the question how this new technology must be shaped to support the maintenance and strengthening of constitutional democracy. This paper first describes the four core elements of today's digital power concentration, which need to be seen in cumulation and which, seen together, are both a threat to democracy and to functioning markets. It then recalls the experience with the lawless Internet and the relationship between technology and the law as it has developed in the Internet economy and the experience with GDPR before it moves on to the key question for AI in democracy, namely which of the challenges of AI can be safely and with good conscience left to ethics, and which challenges of AI need to be addressed by rules which are enforceable and encompass the legitimacy of democratic process, thus laws. The paper closes with a call for a new culture of incorporating the principles of democracy, rule of law and human rights by design in AI and a three-level technological impact assessment for new technologies like AI as a practical way forward for this purpose.
This article is part of a theme issue ‘Governing artificial intelligence: ethical, legal, and technical opportunities and challenges’.
Apples, oranges, robots: four misunderstandings in today's debate on the legal status of AI systems
Authors: Pagallo Ugo 
Published: October 2018

Scholars have increasingly discussed the legal status(es) of robots and artificial intelligence (AI) systems over the past three decades; however, the 2017 resolution of the EU parliament on the ‘electronic personhood’ of AI robots has reignited and even made current debate ideological. Against this background, the aim of the paper is twofold. First, the intent is to show how often today's discussion on the legal status(es) of AI systems leads to different kinds of misunderstanding that regard both the legal personhood of AI robots and their status as accountable agents establishing rights and obligations in contracts and business law. Second, the paper claims that whether or not the legal status of AI systems as accountable agents in civil––as opposed to criminal––law may make sense is an empirical issue, which should not be ‘politicized’. Rather, a pragmatic approach seems preferable, as shown by methods of competitive federalism and legal experimentation. In the light of the classical distinction between primary rules and secondary rules of the law, examples of competitive federalism and legal experimentation aim to show how the secondary rules of the law can help us understanding what kind of primary rules we may wish for our AI robots.
This article is part of the theme issue ‘Governing artificial intelligence: ethical, legal, and technical opportunities and challenges’.
Degron-tagged reporters probe membrane topology and enable the specific labelling of membrane-wrapped structures
Authors: Beer Katharina B , Fazeli Gholamreza , Judasova Kristyna , Irmisch Linda , Causemann Jona , Mansfeld Jörg , Wehman Ann M 
Published: October 2018

AbstractVisualization of specific organelles in tissues over background fluorescence can be challenging, especially when reporters localize to multiple structures. Instead of trying to identify proteins enriched in specific membrane-wrapped structures, we used a selective degradation approach to remove reporters from the cytoplasm or nucleus ofC. elegansembryos and mammalian cells. We demonstrate specific labelling of organelles using degron-tagged reporters, including extracellular vesicles, as well as individual neighbouring membranes. These degron-tagged reporters facilitate long-term tracking of released cell debris and cell corpses, even during uptake and phagolysosomal degradation. We further show that degron protection assays can probe the topology of the nuclear envelope and plasma membrane during cell division, giving insight into protein and organelle dynamics. As endogenous and heterologous degrons are used in bacteria, yeast, plants, and animals, degron approaches can enable the specific labelling and tracking of proteins, vesicles, organelles, cell fragments, and cells in many model systems.
Metastatic tumor cells exploit their adhesion repertoire to counteract shear forces during intravascular arrest
Authors: Osmani Naël , Follain Gautier , Leòn Marìa Jesùs Garcia , Lefebvre Olivier , Busnelli Ignacio , Larnicol Annabel , Harlepp Sébastien , Goetz Jacky G. 
Published: October 2018

SUMMARYCancer metastasis is a process whereby a primary tumor spreads to distant organs. We have previously demonstrated that blood flow controls the intravascular arrest of circulating tumor cells (CTCs), through stable adhesion to endothelial cells. We now aim at defining the contribution of cell adhesive potential and at identifying adhesion receptors at play. Early arrest is mediated by the formation of weak adhesion depending on CD44 and integrin αvβ3. Stabilization of this arrest uses integrin α5β1-dependent adhesions with higher adhesion strength, which allows CTCs to stop in vascular regions with lower shear forces. Moreover, blood flow favors luminal deposition of fibronectin on endothelial cells, an integrin α5β1 ligand. Finally, we show that only receptors involved in stable adhesion are required for subsequent extravasation and metastasis. In conclusion, we identified the molecular partners that are sequentially exploited by CTCs to arrest and extravasate in vascular regions with permissive flow regimes.
Mitochondria-Associated Membranes (MAMs) are involved in Bax mitochondrial localization and cytochrome c release
Authors: Légiot Alexandre , Céré Claire , Dupoiron Thibaud , Kaabouni Mohamed , Manon Stéphen 
Published: October 2018

AbstractThe distribution of the pro-apoptotic protein Bax in the outer mitochondrial membrane (OMM) is a central point of regulation of apoptosis. It is now widely recognized that parts of the endoplasmic reticulum (ER) are closely associated to the OMM, and are actively involved in different signalling processes. We adressed a possible role of these domains, called Mitochondria-Associated Membranes (MAMs) in Bax localization and fonction, by expressing the human protein in a yeast mutant deleted of MDM34, a ERMES component (ER-Mitochondria Encounter Structure). By affecting MAMs stability, the deletion of MDM34 altered Bax mitochondrial localization, and decreased its capacity to release cytochrome c. Furthermore, the deletion of MDM34 decreased the size of an uncompletely released, MAMs-associated pool of cytochrome c.
Opioids trigger breast cancer metastasis through E-Cadherin downregulation and STAT3 activation promoting epithelial-mesenchymal transition
Authors: Tripolt Sabrina , Knab Vanessa M. , Neubauer Heidi A. , Elmer Dominik P. , Aberger Fritz , Moriggl Richard , Fux Daniela A. 
Published: October 2018

AbstractThe opioid crisis of pain medication bears risks from addiction to cancer progression, but little experimental facts exist. Expression of δ-opioid receptors (DORs) correlates with poor prognosis for breast cancer (BCa) patients, but mechanism and genetic/pharmacologic proof of key changes in opioid-triggered cancer biology are lacking. We show that oncogenic STAT3 signaling and E-Cadherin downregulation are triggered by opioid-ligated DORs, promoting metastasis. Human and murine transplanted BCa cells (MDA-MB-231, 4T1) displayed enhanced metastasis upon opioid-induced DOR stimulation, and DOR-antagonist blocked metastasis. Opioid-exposed BCa cells showed enhanced migration, STAT3 activation, down-regulation of E-Cadherin and expression of epithelial-mesenchymal transition (EMT) markers. STAT3 knockdown or upstream inhibition through the JAK1/2 kinase inhibitor ruxolitinib prevented opioid-induced BCa cell metastasis and migration. We conclude that opioids trigger metastasis through oncogenic JAK1/2-STAT3 signaling.
Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma
Authors: Shackleford GM , Mahdi MY , Moats RA , Hawes Debra , Tran HC , Hoang T , Meng E , Erdreich-Epstein A 
Published: October 2018

AbstractLeptomeningeal metastasis remains a difficult clinical challenge. Some success has been achieved by direct administration of therapeutics into the cerebrospinal fluid (CSF) circumventing limitations imposed by the blood brain barrier. Here we investigated continuous infusion versus bolus injection of therapy into the CSF in a preclinical model of human Group 3 medulloblastoma, the molecular subgroup with the highest incidence of leptomeningeal disease. Initial tests of selected Group 3 human medulloblastoma cell lines in culture showed that D283 Med and D425 Med were resistant to cytarabine and methotrexate. D283 Med cells were also resistant to topotecan, whereas 1 μM topotecan killed over 99% of D425 Med cells. We therefore introduced D425 Med cells, modified to express firefly luciferase, into the CSF of immunodeficient mice. Mice were then treated with topotecan or saline in five groups: continuous intraventricular (IVT) topotecan via osmotic pump (5.28 μg/day), daily bolus IVT topotecan injections with a similar daily dose (6 μg/day), systemic intraperitoneal injections of a higher daily dose of topotecan (15 μg/day), daily IVT pumped saline and daily intraperitoneal injections of saline. Bioluminescence analyses revealed that both IVT topotecan treatments effectively slowed leptomeningeal tumor growth in the brains, although histological analysis showed that they were associated with localized brain necrosis. In the spines, bolus IVT topotecan showed a trend towards slower tumor growth compared to continuous (pump) IVT topotecan, as measured by bioluminescence. Both continuous and bolus topotecan IVT showed similar survival that was longer compared to other groups. Thus, both direct IVT topotecan CSF delivery methods produced better anti-medulloblastoma effect compared to systemic therapy at the dosages used here.
Awareness of alternative gluten-free grains for individuals with coeliac disease
Authors: Laheri Zainab , Soon Jan Mei 
Published: October 2018

Purpose
Coeliac disease (CD) is a prevalent autoimmune disorder, affecting 1 in 100 of all individuals in the UK. Currently, the only treatment for CD is the complete avoidance of gluten, a protein commonly found in wheat, rye and barley. The use of alternative grains (AG) is highly recommended to individuals with CD to improve and diversify their diet. The purpose of this paper is to determine the current knowledge of the gluten-free diet (GFD), consumption rates of AG and awareness of AG, for individuals diagnosed with CD.

Design/methodology/approach
A total of 100 participants were recruited via local coeliac support groups as well as an “Allergy and Free From Show”, to participate in a survey. Consent was obtained from all organisations and all individual participants, prior to collecting data. The questionnaire consists of ten questions, related to participants’ demographic characteristics, knowledge of gluten-free food (GFF) and AG and consumption rate of AG. χ2 analyses were conducted to compare the variables between gender and time of diagnosis.

Findings
Overall, both genders possessed good knowledge of the GFD. Yogurt, vinegar and oats resulted in the highest incorrect responses. It was found that females possessed better knowledge of both GFF and AG. Rice, quinoa and corn were amongst the most popular AG consumed whilst job’s tears, fonio and sorghum were the least consumed grains. Females reported a higher consumption rate of AG than males. Additionally, those more recently diagnosed had poorer knowledge of the GFD, reduced consumption rates of AG and poor awareness of AG.

Originality/value
It can be suggested that the incorporation of AG into the diet can prove beneficial for coeliacs and that both knowledge and education play a fundamental role in determining consumption rates amongst individuals.
High-performance unsymmetric 3-node triangular membrane element with drilling DOFs can correctly undertake in-plane moments
Authors: Shang Yan , Cen Song , Qian Zheng-Hua , Li Chenfeng 
Published: October 2018

Purpose
This paper aims to propose a simple but robust three-node triangular membrane element with rational drilling DOFs for efficiently analyzing plane problems.

Design/methodology/approach
This new element is developed within the general framework of unsymmetric FEM. The element test functions are determined by using a conforming displacement field which is slightly different with the classical Allman’s interpolations, while a self-equilibrated stress field formulated based on the analytical airy stress solutions is adopted as the trial functions. To ensure the correctness between the drilling DOFs and the true rotations in elasticity, reasonable constraints are introduced through the penalty function method. Moreover, the special quadrature strategy is used for operating related integrations for future enrichment of element behavior.

Findings
Numerical benchmark tests reveal that this new triangular membrane element has exceptional prediction capabilities. In particular, this element can correctly reproduce a rigid body rotation motion and correctly undertake the external in-plane twisting moments; thus, it is a reasonable choice for being used to formulate flat shell elements or to be connected with other kind of elements with physical rotational DOFs.

Originality/value
This work provides a new approach for developing high-performance lower-order elements with simple formulations and good numerical accuracies.
Lévy flight trajectory-based whale optimization algorithm for engineering optimization
Authors: Zhou Yongquan , Ling Ying , Luo Qifang 
Published: October 2018

Purpose
This paper aims to represent an improved whale optimization algorithm (WOA) based on a Lévy flight trajectory and called the LWOA algorithm to solve engineering optimization problems. The LWOA makes the WOA faster, more robust and significantly enhances the WOA. In the LWOA, the Lévy flight trajectory enhances the capability of jumping out of the local optima and is helpful for smoothly balancing exploration and exploitation of the WOA. It has been successfully applied to five standard engineering optimization problems. The simulation results of the classical engineering design problems and real application exhibit the superiority of the LWOA algorithm in solving challenging problems with constrained and unknown search spaces when compared to the basic WOA algorithm or other available solutions.

Design/methodology/approach
In this paper, an improved WOA based on a Lévy flight trajectory and called the LWOA algorithm is represented to solve engineering optimization problems.

Findings
It has been successfully applied to five standard engineering optimization problems. The simulation results of the classical engineering design problems and real application exhibit the superiority of the LWOA algorithm in solving challenging problems with constrained and unknown search spaces when compared to the basic WOA algorithm or other available solutions.

Originality value
An improved WOA based on a Lévy flight trajectory and called the LWOA algorithm is first proposed.
Multi-scale computational modeling for concrete damage by mixed pore pressures – case of coupled alkali–silica reaction and cyclic freeze/thaw
Authors: Gong Fuyuan , Takahashi Yuya , Maekawa Koichi 
Published: October 2018

Purpose
This paper aims to propose a multi-scale simulation approach for the concrete macro-mechanical damage caused by mixed micro-pore pressures, such as the coupled alkali–silica reaction (ASR) and freeze-thaw cycles (FTC).

Design/methodology/approach
The micro-physical events are computationally modeled by considering the coupling effect between ASR gel and condensed water in the mixed pressure and motion. The pressures and transport of pore substances are also linked with the concrete matrix deformation at macro-scale through a poro-mechanical approach, and affect each other, reciprocally. Once the crack happens in the nonlinear analysis, both the micro-events (water and gel motion) and the macro mechanics will be mutually interacted. Finally, different sequences of combined ASR and FTC are simulated.

Findings
The multi-chemo mechanistic computation can reproduce complex events in pore structures, and further the macro-damages. The results show that ASR can reduce the FTC expansion for non-air-entrained concrete, but may increase the frost damage for air-entrained concrete. The simulation is examined to bring about the observed phenomena.

Originality/value
This paper numerically clarifies the strong linkage between macro-mechanical deformation and micro-chemo-physical events for concrete composites under coupled ASR and FTC.
Influence of velocity head on filling transients in a branched pipeline
Authors: Wang Ling , Wang Fujun , Karney Bryan William , Malekpour Ahmad , Wang Zhengwei 
Published: October 2018

Purpose
The velocity head is usually neglected in the energy equation for a pipeline junction when one-dimensional (1D) hydraulic transient flow is solved by method of characteristics. The purpose of this paper is to investigate the effect of velocity head on filling transients in a branched pipeline by an energy equation considering velocity head.

Design/methodology/approach
An interface tracking method is used to locate the air–water interface during pipeline filling. The pressured pipe flow is solved by a method of characteristics. A discrete gas cavity model is included to permit the occurrence of column separation. A universal energy equation is built by considering the velocity head. The numerical method is provisionally verified in a series pipeline and the numerical results and experimental data accord well with each other.

Findings
The numerical results show that some differences in filling velocity and piezometric head occur in the branched pipeline. These differences arise because the velocity head in the energy equation can become an important contributor to the hydraulic response of the system. It is also confirmed that a local high point in the profile is apt to experience column separation during rapid filling. Significantly, the magnitude of overpressure and cavity volume induced by filling transients at the local high point is predicted to increase with the velocity in the pipes.

Originality/value
The velocity head in the energy equation for a pipeline junction could play an important role in the prediction of filling velocity, piezometric head and column separation phenomenon, which should be given more attention in 1D hydraulic transient analysis.
Analysis of freezing process about falling droplet using the lattice Boltzmann method
Authors: Zhao Xin , Dong Bo , Li Weizhong 
Published: October 2018

Purpose
The freezing phenomenon of a falling droplet is a frequently encountered phenomenon in various applications, such as spray crystallization, hail formation and artificial snowmaking. Therefore, this paper aims to understand the freezing processes of a falling droplet without and with initial horizontal velocity in a cold space.

Design/methodology/approach
The freezing processes of a falling droplet were characterized using a modified enthalpy-based lattice Boltzmann method.

Findings
The temperature field, streamlines and freezing process of the falling droplet were investigated and analyzed. The lower part of the droplet was frozen earlier than the upper part. The freezing trend slowed down in the later stage of the freezing process. The droplet shape was related to the initial vertical velocity, nucleation temperature and initial horizontal velocity.

Originality/value
A modified enthalpy-based lattice Boltzmann method is proposed. In the model, the improved pseudo-potential model is used and the radiation is considered. This method was firstly used to simulate the freezing process of a falling droplet. By examining these freezing processes in detail, the freezing trend and the effect factors of droplet deformation and freezing time were obtained, respectively.