bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipophagy and epigenetic alterations are related to metabolic dysfunction-associated steatotic liver disease progression in an experimental model
Authors: Schütz Felipe , Longo Larisse , Keingeski Melina Belén , Filippi-Chiela Eduardo , Uribe-Cruz Carolina , Álvares-da-Silva Mário Reis 
Published: November 2024

BACKGROUND
Genetic and epigenetic alterations are related to metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis.
AIM
To evaluate micro (mi)RNAs and lipophagy markers in an experimental model of metabolic dysfunction-associated steatohepatitis (MASH).
METHODS
Adult male Sprague Dawley rats were randomized into two groups: Control group (n = 10) fed a standard diet; and intervention group (n = 10) fed a high-fat-choline-deficient diet for 16 weeks. Molecular evaluation of lipophagy markers in liver tissue [sirtuin-1, p62/sequestosome-1, transcription factor-EB, perilipin-2 (Plin2) , Plin3 , Plin5 , lysosome-associated membrane proteins-2, rubicon, and Cd36 ], and serum miRNAs were performed.
RESULTS
Animals in the intervention group developed MASH and showed a significant decrease in sirtuin-1 (P = 0.020) and p62/sequestosome-1 (P < 0.001); the opposite was reported for transcription factor-EB (P = 0.020), Plin2 (P = 0.003), Plin3 (P = 0.031), and Plin5 (P = 0.005) compared to the control group. There was no significant difference between groups for lysosome-associated membrane proteins-2 (P = 0.715), rubicon (P = 0.166), and Cd36 (P = 0.312). The intervention group showed a significant increase in miR-34a (P = 0.005) and miR-21 (P = 0.043) compared to the control. There was no significant difference between groups for miR-375 (P = 0.905), miR-26b (P = 0.698), and miR-155 (P = 0.688).
CONCLUSION
Animals with MASH presented expression changes in markers related to lysosomal stress and autophagy as well as in miRNAs related to inflammation and fibrogenesis, processes that promote MASLD progression.
Complexes of the antibiotic drug succinylsulfathiazole with the La(III), Sm(III), and Tb(III) ions: Spectral characterizations, microscopic pictures, and thermal properties
Authors: A. Almehizia Abdulrahman , M. Alkahtani Hamad , Alhaj Zen Amer , J. Obaidullah Ahmad , M. Naglah Ahmed , M. Alzughaibi Moayad , H. Eldaroti Hala 
Published: November 2024

Reacting the antibiotic drug succinylsulfathiazole (abbreviated as SST) with the lanthanide metal ions La(III), Sm(III), and Tb(III) generated thermal stable metal-based complexes. The temperature of the reaction was 70 oC, at a pH of ~ 8.5, using stoichiometry of 2:1 (SST ligand to metal ion). Spectral and analytical characterizations of the SST metal-based complexes were obtained using ultraviolet/visible (UV-visible), Fourier-transform infrared (FT-IR) spectroscopies, X-ray diffractometry (XRD), and CHN elemental analysis. The microscopic pictures of the SST complexes were captured by a high-resolution scanning electron microscope with environmental mode (ESEM). Experimental data suggested that the general composition of La(III) complex is [La(SST)2(H2O)Cl].6H2O with a gross formula of C26H38N6O17S4ClLa, the general composition of Sm(III) complex is [Sm(SST)2(H2O)(NO3)].5H2O with a gross formula of C26H36N7O19S4Sm, whereas the general composition of Tb(III) complex is [Tb(SST)2(H2O)(NO3)].4H2O with a gross formula of C26H34N7O18S4Tb. In the manufactured complexes, two deprotonated SST molecules were captured the La(III), Sm(III), and Tb(III) ions by their bidentate carboxylate groups (COO-). The microscopic pictures clearly revealed different surface topography between SST metal-based complexes.
KEY WORDS: Succinylsulfathiazole, Lanthanides, SEM, Surface morphology, EDS profile
Bull. Chem. Soc. Ethiop. 2025, 39(2), 327-339.
DOI: https://dx.doi.org/10.4314/bcse.v39i2.11
Administration of gene replacement therapy in patients with spinal muscular atrophy 5q type 1 with chronic nosocomial bronchopulmonary infection
Authors: Papina Yuliya O. , Artemyeva Svetlana B. , Belousova Elena D. , Volynets Galina V. , Dyakova Svetlana E. , Rastegina Svetlana E. , Melnik Evgeniya A. , Komarova Oksana N. , Podgorny Andrey N. , Vlodavets Dmitry V. 
Published: December 2024

Introduction. Spinal muscular atrophy (SMA) 5q is a severe hereditary neuromuscular disorder, one of the serious manifestations of which is the development of progressive respiratory insufficiency. The administration of pathogenetic therapy leads to decreased symptoms of respiratory failure, which reduces the risk of lethal outcome and is fundamental for stabilizing the progression of physical development and new motor skills in SMA patients.
The aim — to present experience of onasmenogen abeparvovec (OA) gene replacement therapy (GRT) in patients with SMA type 1 and severe respiratory failure combined with chronic bronchopulmonary infection caused by nosocomial multidrug-resistant microflora in real clinical practice.
Materials and methods. Five patients with SMA type 1 and respiratory failure of second degree complicated by chronic bronchopulmonary infection were enrolled in this study. All patients were performed a comprehensive clinical, laboratory, and radiologic examination before and for two years after GRT OA administration toof evaluate the severity of respiratory disturbances. The efficiency of OA therapy was estimated with the Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND), and motor development was assessed by the Hammersmith Infant Neurologic Examination Part 2 (HINE-2).
Results. The medical records of 5 (four boys and one girl ) patients with SMA type 1 at the mean age of 19 months (13 to 27 months) at the time of GRT OA administration were analyzed, of them. All patients had been treated with a different type of pathogenetic therapy before GRT OA. After the preventive, personalized antibacterial therapy, all patients experienced GRT OA administration without exacerbation of chronic bronchopulmonary infection, despite hormonal therapy in an immunosuppressive dose (1 mg/kg). There were no lethal outcomes during two years after GRT OA. Over the first year, patients demonstrated a progressive increase in motor skills with further stabilization, but during the second year of follow-up, two patients showed moderate regression of motor skills after pneumonia. One of five patients had a positive lung function dynamics and eradication of highly pathogenic bacterial microflora from the respiratory tract.
Conclusions. It is comparatively safe to administer GRT OA in children with SMA type 1 and chronic respiratory infection. However, changing pathogenetic therapy to GRT OA in the cases we presented did not have clinically significant advantages and required more careful patient preparation. Additional risks associated with the occurrence of immune-mediated adverse events due to concomitant hormonal therapy, which can be avoided on other types of pathogenetic therapy, should be considered.
Propuestas didácticas que vinculan el currículo de nivel primario con las habilidades para la vida
Authors: León Montti María Natalia 
Published: November 2024

OBJETIVO: diseñar una propuesta metodológica que permita incrementar la motivación hacia el aprendizaje de competencias vinculadas con las habilidades para la vida en estudiantes de primer grado de nivel primario del sector público. MÉTODO: investigación cualitativa, alcance descriptivo, figura fenomenológica, muestra aleatoria simple compuesta por 3 docentes, 20 estudiantes de primer grado, nivel primario y directora de centro escolar; técnicas utilizadas: análisis documental, observación, registro anecdótico, entrevista y grupo focal. RESULTADOS: la mayoría de los niños identifican como primera idea de orientación vocacional aquellas profesiones u oficios que se encuentran en su entorno familiar y social, además de no relacionar el desarrollo de sus competencias con las habilidades para la vida; no creen que tenga una importancia real el aprendizaje que pueden adquirir en la escuela, debido a la falta de motivación propia y del entorno para dar seguimiento a su vida académica en el futuro; esta información permitió tener un diagnóstico de los sujetos curriculares y además estos resultados aportaron insumos básicos para el diseño de una guía metodológica didáctica bajo el enfoque de enseñanza por competencias para el desarrollo de actividades de aprendizaje. CONCLUSIÓN: el fenómeno observado nos permite determinar que éste puede ser modificado al aplicar un estímulo por medio de la implementación de estrategias metodológicas didácticas activas, que promuevan, por medio de la realización de actividades de aprendizaje integrales, la vinculación curricular de las competencias declaradas en el Currículo Nacional Base con las habilidades para la vida.
Analyzing The Dynamics Of Tourist Inflows: A Comparative Examination Of Patterns Across Selected Balkan Nations
Authors: Kalaj Ermira , Kroni Fatjona , Barbullushi Erjola 
Published: November 2024

Objective: This study employs time series analysis to examine the factors influencing fluctuations in tourist arrivals within a certain timeframe (2005-2021) across a chosen set of Western Balkan nations.

Theoretical Framework: The countries that have been chosen for this study are Albania, Croatia, Montenegro, and Greece. These nations exhibit distinct attributes in terms of their socio-economic development patterns; nonetheless, they share commonalities in terms of their coastal topography and cultural heritage influences. The empirical literature indicates that factors such as income and prices play a crucial role in determining the demand for tourism arrivals.

Method: In this study, GMM models will be employed to analyze the relationship between the number of tourist arrivals and international tourism receipts. The models will incorporate various independent variables, including GDP growth rate, consumer price index, exchange rate, transportation costs, and other pertinent factors associated with tourism infrastructure.

Results and Discussion: Based on our estimation results, we have observed small variations among countries, indicating a relatively low amount of price elasticity. Nevertheless, when considering Balkan countries, it is shown that income level and currency rates hold greater significance.

Research Implications: The shared aims highlight that all the countries in the research have equal starting points and potential. Sharing shared objectives and being cognizant of their geographical character enhances the efficiency of the sector, enables the resolution of national-level inequalities, and facilitates cross-country cooperation.

Originality/Value: The findings imply that the logistic performance has a favorable impact in every country case, except for Albania. The result might have an impact on policy considering the crucial function of logistics and infrastructure in tourism development.
Implementation of 5083 Aluminum Material Due to Heat Treatment with Impact Testing System
Authors: Junaidi  , Ibrahim Husin , Napid Suhardi , Siagian Tony , Seregar Irpansyah , Rahmadsyah  , Tanjung Darlina , Sarifah Jupriah 
Published: November 2024

Objective: This study investigates the effects of heat treatment on the properties of 5083 aluminum alloy, focusing on impact testing.

Theoretical Framework: The process involves forming and cutting the aluminum material, followed by heating in a furnace. The samples are then cooled using different media: seawater, oil, and air.

Method: Natural cooling treatments with seawater, lubricating oil, and air were employed in this research.

Results and Discussion: The optimal conditions yielded the highest tensile strength and strain values, with results of 196.48 N/mm² and 6.91%, respectively, for samples cooled in seawater compared to oil. For impact strength, the greatest value was achieved using seawater as the cooling medium, measuring 0.42 J/mm². The highest flexural strength, recorded at 69.77 N/mm², was observed in samples cooled with oil.

Research Implications: The findings indicate that natural cooling treatments significantly influence mechanical properties, with seawater providing superior impact strength, while oil cooling results in enhanced flexural strength.

Originality/Value: This study reveals that the lowest values for impact and flexural strength occur in welding materials subjected to natural cooling. Conversely, the tensile strength and strain improve in welding materials subjected to controlled cooling, indicating increased hardness.
Testing The Validity of Zero-Beta Capm in Vietnamese Stock Market
Authors: Khanh Thai Hong Thuy , Anh Nguyen Cao 
Published: November 2024

Objectives: This study examines the validity of the Zero-Beta Capital Asset Pricing Model (CAPM) in the context of Vietnam's stock market, exploring its potential for sustainable, SDG-aligned investment without relying on a traditional risk-free interest rate.

Theoretical Framework: The research builds on Black's (1972) Zero-Beta CAPM framework, addressing limitations of the riskless rate assumption in emerging markets where stable growth is essential.

Method: Using a dataset of daily returns from 365 stocks listed on the Ho Chi Minh City Stock Exchange (2008-2024), the study applies Ordinary Least Squares (OLS) regression to calculate alpha and beta values, testing for a sensitive zero-beta return that correlates with sustainable investment goals.

Results and Discussion: The analysis reveals a daily sensitive zero-beta return of 0.0149%, surpassing the Vietnamese 15-year government bond rate, thus supporting Zero-Beta CAPM's validity without a risk-free rate. This suggests that zero-beta CAPM can offer a viable approach for sustainable investment in Vietnam, enhancing returns through portfolio ownership.

Research Implications: The study demonstrates the feasibility of applying CAPM to emerging markets with sustainability considerations, positioning the sensitive zero-beta return as a proxy for sustainable market portfolio ownership.

Originality/Value: This research expands CAPM’s theoretical scope by adapting it to markets with unique sustainability demands, providing insights into leveraging market portfolio ownership for improved investment performance in Vietnam’s stock market.
Aetiologies and Management of Retropharyngeal Abscess in Paediatric Age Group
Authors: Kumar Prem , Somashekhar Abhilasha 
Published: November 2024

Introduction: Retropharyngeal abscess (RPA) is deep neck space infection which requires prompt diagnosis and management due to its potential life-threatening nature. In paediatric group it is most common between 3-5 years of age with infants presenting it very rarely. We are reporting a case series of all the children who were diagnosed of RPA and managed successfully.
Materials and methods: This is a single‑center, retrospective study conducted at the tertiary care hospital. Detailed data from the case files of patients who were diagnosed and managed for RPA from 2012 to 2022 were included. The demographic details, presenting complaints, site of involvement, CT findings, intra-operative findings, pus culture report and course of child during hospitalization was meticulously documented along with their follow up findings and analysed.
Results: Total number of children who underwent treatment for RPA during the study period is 17. maximum number of cases were below 4 years of age accounting for 65%. 58.8 % had an episode of Upper respiratory tract infection before developing the RPA. 2 patients were diagnosed to have tuberculosis and had started on Anti tubercular treatment. One child had sustained injury to neck, and one had history of chicken bone ingestion. Five children showed the complications of which 60% of them were infant:
Conclusion: The crucial step in infants with RPA is prompt diagnosis and aggressive management. Initial antibiotics should be a broad spectrum until the pus culture sensitivity reports are available. There is a recent trend is Methicillin resistant staphylococcus aureus especially in younger children. Paradoxical reaction of tubercular treatment is rare and should be borne in mind of its possibilities while treating.
Evaluating Functional Outcome of Oblique Cut across Mentum in Advanced Oral Squamous Cell Carcinoma
Authors: Shomes Mozumder  , Shilpi Agrawal  , Dam Aniruddha , Anup Kumar Bhowmick  , Ishita Sinha  
Published: November 2024

Introduction:
Segmental / hemi mandibulectomy is standard for advanced oral Squamous cell cancer. Sometimes the mentum needed to include to achieve an adequate resection. Loss of which often leads to a variety of complications. Evaluation of the functional outcome has been done in those cases which were unsuitable for free flap reconstruction so & an oblique cut was placed across mentum & pedicle flap was done instead.
Material and methods:
In this study from 26 December 2022 to 25 March 2023, the effect of oblique cut across mentum in 10 patients of oral SCC were analysed for functional outcome over next 3 months.
Results:
Successful decanulation from tracheostomy tube were achieved in all patients by 6weeks. By 12 weeks Nasogastric tube removal and commencement of oral feeding were achieved in all. Complete oral competency were achieved in all by 12 weeks.
Conclusion:
Mandibular reconstruction is necessary to restore postoperative function. Free flaps remain the first choice. But sometimes the patients’ age, overall health & co- morbidities are not in favour; hence pedicle flaps are needed. Preserving the mentum with clear margin then requires very stringent case selection. This novel approach, in selected cases may solve a lot of functional issues.
FINANCIAL EDUCATION AS A SUPPORT FOR ENTREPRENEURSHIP IN TECHNICAL HIGH SCHOOL STUDENTS
Authors: Vera Mendoza Freddy , Jalca Moreira Walter Enrique , Pincay Reyes Verónica Isabel , Macías Solórzano Jennifer Valeria 
Published: December 2024

Los programas educativos en el ámbito de las finanzas y el emprendimiento como impulso laboral temprano, son una meta en el sistema educativo ecuatoriano, por ello el objetivo de esta investigación fue analizar el impacto de la educación financiera para el emprendimiento de jóvenes bachilleres a una temprana edad de manera sostenible. Para el análisis de la problemática de la investigación se realizó un estudio previo del contexto educativo, económico y social de los programas educativos actuales. Para este efecto, se realizó una revisión documental-bibliográfica de trabajos relacionados con la temática, con lo cual se fundamentó y contrastó el contenido teórico. La investigación tuvo un enfoque cualitativo. Se concluyó que las principales dificultades para garantizar la sostenibilidad de los emprendimientos es una inadecuada cultura financiera, así como la falta innovación en los planteles educativos que permita competitividad en los mercados locales
The Informational Importance Provided by the Cash Flow Statement Follows International Standards in Assessing Financial Liquidity
Authors: Tariq Jassim Mohammad  
Published: November 2024

Purpose: The research aims to emphasize the informational significance of the statement of cash flows by international accounting standards in assessing the financial liquidity of selected banks for the period (2019–2023). The study employs financial ratios derived from the cash flow statement to analyze and evaluate the financial liquidity of these banks.
Materials and Methods: The research adopts a quantitative analytical approach, relying on financial ratios extracted from the statement of cash flows. These ratios are used to assess the financial liquidity of the banks in the research sample. The analysis focuses on short-term and long-term financial obligations, ensuring a comprehensive evaluation of monetary liquidity.
Findings: The research concludes that the statement of cash flows provides essential information for assessing financial liquidity. It demonstrates that this statement is valuable for investors, creditors, lenders, and other stakeholders in evaluating banks' ability to meet their short-term and long-term financial obligations. Additionally, the findings confirm the hypothesis that the cash flow statement is fundamental in providing critical insights for financial liquidity assessment.
Implications to Theory, Practice and Policy: The research recommends enhancing awareness among financial statement recipients regarding the informational importance of the cash flow statement. It highlights the statement's role in predicting future cash flows and its effectiveness in assessing financial liquidity. The study suggests promoting educational initiatives and tools to help stakeholders fully utilize the insights provided by the cash flow statement.
daño al proyecto de vida como daño a la persona
Authors: Zamora-Smith David Ellister 
Published: November 2024

El presente trabajo tiene por finalidad aportar precisión conceptual con respecto al daño al proyecto de vida y sus características esenciales. De este modo podríamos ensayar la reparación integral basada en parámetros previamente establecidos ante un daño -conceptualmente- autónomo pero que todavía se mantiene en la sombra del daño moral, a pesar de gozar de bases sólidas como parte del daño a la persona.
A lo largo de nuestro ensayo hacemos mención especial de la labor del jurista peruano Carlos Fernández Sessarego, quien, en miras de desarrollar un derecho justo, realizó diversos estudios relacionados al daño a la persona, adoptando diversas reflexiones provenientes del derecho italiano, dedicando parte de su vida a demostrar un nuestro sistema jurídico latinoamericano la posibilidad de reconocer el daño al proyecto de vida.
Línea del tiempo en la Criminología
Authors: Robles Carmen Rosa 
Published: November 2024

Este artículo pasa revista a una secuencia de eventos a lo largo del tiempo, en relación a la morfología de la Criminología, sus antecedentes y referencias históricas como un aporte didáctico útil para la enseñanza de la Criminología General (Criminología I), destacando de manera clara y sencilla, algunos aspectos importantes de esta ciencia, orientado en la construcción de una sólida base para la investigación en criminología, permitiendo al futuro abogado comprender mejor la evolución de esta disciplina y su relación con otros campos del conocimiento.
Experimental Analysis of Dynamic Vibrations in Rails by Using Different Types of Vibration Absorption Pads
Authors: Kiran Lochela Prabhu , Venkataramiah P. 
Published: December 2024

Railway pads are a type of component that is used in railway construction and maintenance. They are typically made of rubber or similar material and are placed between the railway sleeper and the rail itself. Railway pads provide a layer of cushioning and insulation between the rail and the sleeper, which helps to reduce noise and vibration from passing trains. Railway pads can also help extend the rail's life by reducing the wear and tear caused by constant friction between the rail and sleeper. They are especially useful in areas where noise pollution is a concern, such as residential areas or near hospitals and schools. Several types of railway pads are available, including continuous, discrete, and ribbed designs. The specific type of pad used will depend on factors such as the type of rail being used, the expected loads and speeds of passing trains, and the requirements of the railway system. Overall, railway pads are an important component in the construction and maintenance of railway systems, helping to reduce noise and vibration while also prolonging the life of the rail and other components. In this paper, we are testing three types of vibration rubber pads i.e., Ethylene Propylene Diene Monomer (EPDM), High-Density Polyethylene (HDPE), nitrile and comparing three vibration frequencies. The dynamic frequency of welded rails with HDPE pads has having 1190 Hz mean value. The dynamic frequency of rail tracks with single- and double-layer EPDM pads their mean values are 499 Hz and 335 Hz respectively. The experimental values clearly show that single- and double-layer EPDM pad dynamic frequencies are reduced by up to 58% and 71%, respectively, over the HDPE pad.