bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online grocery retailing – exploring local grocers beliefs
Authors: Kureshi Sonal , Thomas Sujo 
Published: March 2019

Purpose
The purpose of this paper is to understand the beliefs of local grocery retailers about online grocery retailing. Using the theory of planned behavior (TPB), the study explores the outcome, normative and control beliefs held by the local grocers about online grocery retailing which would eventually translate into behavior. Factors influencing local grocers intention to participate or refusing to participate in the online grocery retailing was investigated.

Design/methodology/approach
In total, 20 in-depth interviews with local grocery retailers were conducted ranging from small to large sized retail stores from a city in the western part of India. The sample included two groups of local grocers – first, grocers who partnered with online retailers as suppliers. This group included those retailers who had partnered but discontinued later and second, grocers who had not partnered with online retailers. In-depth interviews with the local grocery retailers were conducted using TPB as a basis to uncover local grocers’ beliefs toward online grocery retailing and predict their behavior.

Findings
The outcome beliefs were classified into five broad heads – business expansion; gaining visibility and reputation; customer expectations; inventory management; and margins, costs and technical issues. The normative belief was that the actions and response to online grocery retailing would be governed by their referent group – the consumers. The main control belief was that partnering with online grocery retailing would result in loss of control regarding their business operations.

Research limitations/implications
The results indicated that in a country like India especially in small to medium size towns, online grocery retailers would have to think of creative ways to involve the local grocery retailers to grow their business. The local grocers due to their size were able to adapt to the requirements of their referent consumers without any additional cost. They were unlikely to give up control regarding how they run their business. The main limitation of this study was the exploratory nature of this study which makes it difficult to prioritize the importance given to each belief. The study sample was restricted to one city in India, and future studies could include other cities.

Practical implications
The findings have practical implications for online grocery retailers who wish to expand into emerging markets like India. It provides understanding about the local grocery retailers who were the major competitors of online grocery retailers. It provides direction to integrate and partner with the local grocers and utilize them for mutual benefits.

Originality/value
Given the absence of academic literature in the public domain, this study provides a platform for future studies in this area. This paper is a systematic attempt to uncover the underlying beliefs of local grocery retailers who were the key players in the grocery retailing business.
Evaluating next‐generation sequencing (NGS) methods for routine monitoring of wild bees: Metabarcoding, mitogenomics or NGS barcoding
Authors: Gueuning Morgan , Ganser Dominik , Blaser Simon , Albrecht Matthias , Knop Eva , Praz Christophe , Frey Juerg E. 
Published: March 2019

AbstractImplementing cost‐effective monitoring programs for wild bees remains challenging due to the high costs of sampling and specimen identification. To reduce costs, next‐generation sequencing (NGS)‐based methods have lately been suggested as alternatives to morphology‐based identifications. To provide a comprehensive presentation of the advantages and weaknesses of different NGS‐based identification methods, we assessed three of the most promising ones, namely metabarcoding, mitogenomics and NGS barcoding. Using a regular monitoring data set (723 specimens identified using morphology), we found that NGS barcoding performed best for both species presence/absence and abundance data, producing only few false positives (3.4%) and no false negatives. In contrast, the proportion of false positives and false negatives was higher using metabarcoding and mitogenomics. Although strong correlations were found between biomass and read numbers, abundance estimates significantly skewed the communities' composition in these two techniques. NGS barcoding recovered the same ecological patterns as morphology. Ecological conclusions based on metabarcoding and mitogenomics were similar to those based on morphology when using presence/absence data, but different when using abundance data. In terms of workload and cost, we show that metabarcoding and NGS barcoding can compete with morphology, but not mitogenomics which was consistently more expensive. Based on these results, we advocate that NGS barcoding is currently the seemliest NGS method for monitoring of wild bees. Furthermore, this method has the advantage of potentially linking DNA sequences with preserved voucher specimens, which enable morphological re‐examination and will thus produce verifiable records which can be fed into faunistic databases.
Efficacy of subsequent docetaxel +/− ramucirumab and S‐1 after nivolumab for patients with advanced non‐small cell lung cancer
Authors: Tamura Nobumasa , Horinouchi Hidehito , Sekine Katsutoshi , Matsumoto Yuji , Murakami Shuji , Goto Yasushi , Kanda Shintaro , Fujiwara Yutaka , Yamamoto Noboru , Ohe Yuichiro 
Published: March 2019

BackgroundCytotoxic chemotherapy for advanced non‐small cell lung cancer (NSCLC) as second‐line or subsequent treatment generally results in a poor treatment outcome. Several reports have indicated that subsequent cytotoxic chemotherapy in patients who have received immune checkpoint inhibitors (ICIs) might have relatively better efficacy.MethodsThe clinical data of advanced NSCLC patients treated with nivolumab during clinical practice at the National Cancer Center Hospital between 17 December 2015 and 31 August 2017 were consecutively reviewed, and the treatment outcomes of docetaxel‐based chemotherapy (docetaxel +/− ramucirumab) or S‐1 after nivolumab were analyzed. The results were then compared with those of advanced NSCLC patients treated with docetaxel or S‐1 but not ICIs during clinical practice between 17 December 2014 and 16 December 2015.ResultsThirty patients were administered docetaxel‐based chemotherapy and 21 patients were administered S‐1 in any line after nivolumab. Twenty‐four patients were administered docetaxel‐based chemotherapy and 15 patients were administered S‐1 immediately after nivolumab. Sixty‐six patients were administered docetaxel and 23 patients were administered S‐1 without ICIs. The objective response rate, disease control rate, and median progression‐free survival duration were 28.6%, 53.6%, and 5.26 months for patients receiving docetaxel‐based chemotherapy or S‐1 immediately after nivolumab treatment; 24.3%, 51.4%, and 3.88 months for patients receiving docetaxel‐based chemotherapy or S‐1 in any line after nivolumab; and 16.4%, 56.7%, and 2.74 months, for patients receiving docetaxel or S‐1 without ICIs, respectively.ConclusionSubsequent cytotoxic chemotherapy, especially immediately after nivolumab, has better treatment efficacy than that of regimens without ICI pretreatment.
Cognitive Behavioral Therapy for Insomnia in Alcohol‐Dependent Veterans: A Randomized, Controlled Pilot Study
Authors: Chakravorty Subhajit , Morales Knashawn H. , Arnedt J. Todd , Perlis Michael L. , Oslin David W. , Findley James C. , Kranzler Henry R. 
Published: March 2019

BackgroundInsomnia is highly prevalent in individuals recovering from alcohol dependence (AD) and increases their risk of relapse. Two studies evaluating cognitive behavior therapy for insomnia (CBT‐I) have demonstrated its efficacy in non‐Veterans recovering from AD. The aim of this study was to extend these findings in an 8‐week trial of CBT‐I in Veterans.MethodsVeterans recovering from AD were randomly assigned to 8 weeks of treatment with CBT‐I (N = 11) or a Monitor‐Only (MO; N = 11) condition and were evaluated 3 (N = 21/22) and 6 months posttreatment (N = 18/22). The primary outcome measure was the Insomnia Severity Index (ISI) score. Secondary outcome measures were sleep diary measures, percent days abstinent (PDA), and scores on the Dysfunctional Beliefs and Attitudes About Sleep Scale (DBAS), Sleep Hygiene Index (SHI), Penn Alcohol Craving Scale (PACS), Quick Inventory of Depressive Symptoms (QIDS), State‐Trait Anxiety Inventory‐Trait (STAI‐T) scale, and Short Form 12‐item (SF‐12). Mixed‐effects regression models, adjusted for race, evaluated differences in outcomes between the groups over a 6‐month period (clinicaltrials.gov identifier = NCT01603381).ResultsSubjects were male, aged 54.5 (SD = 6.9) years, and had 26.4 (SD = 26.3) days of abstinence before their baseline evaluation. CBT‐I produced a significantly greater improvement in model‐based estimates than MO (mean change at 6 months compared to their baseline) for ISI, sleep latency from a daily sleep diary, DBAS mean score, and SHI total score. PDA and QIDS improved over time, but there was no difference between the groups. PACS, STAI‐T, or SF‐12 scale did not show any improvement from their baseline scores.ConclusionsCBT‐I treatment demonstrated substantial efficacy in reducing insomnia, associated negative cognitions, and improving sleep hygiene in Veterans during early recovery, though it did not reduce drinking behavior.
Overnight block trades in the Korean stock market
Authors: Chung Chune Young , Hur Seok‐Kyun , Kim Suk Bong 
Published: March 2019

AbstractWe examine the characteristics of overnight block trades in the Korean stock market from 2004 to 2015. We find that the discount on the offering price is negatively related to the number and return volatility of shares, the offering price is higher for firm‐commitment contracts than for best‐effort contracts, the discount level is lower for larger deal values under best‐effort contracts, commission fee rates and fees are more pronounced under firm‐commitment contracts, and a deal's uncertainty is related to the firm's contract choice. The incentives of sellers and investment banks are aligned unless sellers face an informational disadvantage.
Randomized, double‐blind, placebo, and risperidone‐controlled study of lurasidone in the treatment of schizophrenia: Results of an inconclusive 6‐week trial
Authors: Higuchi Teruhiko , Iyo Masaomi , Kwon Jun Soo , Chou Yuan‐Hwa , Chen Hsing‐Kang , Chen Jen‐Yeu , Chen Tzu‐Ting , Huang San‐Yuan , Lee Jung‐Sik , Saeki Yuichi , Tanaka Hisashi , Wang Tzong‐Shi , Wu Bo‐Jian , Katoh Takao , Ishigouoka Jun 
Published: March 2019

AbstractObjectiveThe efficacy and safety of lurasidone in schizophrenia has been demonstrated in multiple controlled trials, primarily in US and European populations. The aim of the current study was To evaluate lurasidone for the treatment of schizophrenia among patients in Japan, Korea, and Taiwan.MethodsHospitalized patients (N = 460) with schizophrenia were randomized to 6 weeks of fixed‐dose lurasidone 40 mg/d, lurasidone 80 mg/d, risperidone 4 mg/d, or placebo. Efficacy was assessed using the Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression‐Severity (CGI‐S).ResultsNo significant endpoint differences in PANSS total score were found for lurasidone or risperidone vs placebo. Lurasidone was safe and well tolerated, with minimal effects on weight and metabolic parameters.DiscussionThe current study was inconclusive regarding the efficacy of lurasidone in schizophrenia but further confirmed its safety and tolerability.
Do porcine Sertoli cells represent an opportunity for Duchenne muscular dystrophy?
Authors: Chiappalupi Sara , Salvadori Laura , Luca Giovanni , Riuzzi Francesca , Calafiore Riccardo , Donato Rosario , Sorci Guglielmo 
Published: March 2019

AbstractSertoli cells (SeC) are responsible for the immunoprivileged status of the testis thanks to which allogeneic or xenogeneic engraftments can survive without pharmacological immune suppression if co‐injected with SeC. This peculiar ability of SeC is dependent on secretion of a plethora of factors including maturation factors, hormones, growth factors, cytokines and immunomodulatory factors. The anti‐inflammatory and trophic properties of SeC have been largely exploited in several experimental models of diseases, diabetes being the most studied. Duchenne muscular dystrophy (DMD) is a lethal X‐linked recessive pathology in which lack of functional dystrophin leads to progressive muscle degeneration culminating in loss of locomotion and premature death. Despite a huge effort to find a cure, DMD patients are currently treated with anti‐inflammatory steroids. Recently, encapsulated porcine SeC (MC‐SeC) have been injected ip in the absence of immunosuppression in an animal model of DMD resulting in reduction of muscle inflammation and amelioration of muscle morphology and functionality, thus opening an additional avenue in the treatment of DMD. The novel protocol is endowed with the advantage of being potentially applicable to all the cohort of DMD patients regardless of the mutation. This mini‐review addresses several issues linked to the possible use of MC‐SeC injected ip in dystrophic people.
Interface reaction‐governed heteroepitaxial growth of YBa2Cu3O7‐δ film on CeO2‐buffered technical substrate
Authors: Chu Jingyuan , Zhao Yue , Ji Yaotang , Wu Wei , Shi Jiangtao , Hong Zhiyong , Ma Lin , Suo Hongli , Jin Zhijian 
Published: March 2019

AbstractDue to the high growth rate and environmental‐friendly, fluorine‐free metal‐organic decomposition routes (FF‐MOD) have attracted more attention for growth of high‐quality YBa2Cu3O7‐δ (YBCO) films. Few works have been performed when using technical substrates. In this study, correlation among the sintering process, microstructure, and superconductivity of the YBCO was systematically established on the technical substrates capped with CeO2 layer. We found that the optimal process conditions are mainly related to the enhanced transient liquid phase and BaCeO3. Combined X‐ray diffraction and scanning electron microscopy analyses indicate that high‐quality growth of YBCO film is a trade‐off of two different competition phenomena during sintering: (a) the presence of enhanced transient liquid phase, (b) the formation of BaCeO3 at the interface. The former is beneficial to YBCO epitaxial growth/structure rearrangement, while the latter should be suppressed in view of minimizing YBCO partial decomposition triggered by the interfacial reaction. Moreover, we confirmed that both two aforementioned phenomena are somehow associated with the cross‐linkage between the sintering temperature and pO2 during the YBCO conversion. According to this systemic study, the key parameters are defined to avoid the BaCeO3 formation prior to the YBCO orientation nucleation. Structure and superconductivity of the YBCO film were also investigated. Remarkably, a high Jc value of 3.69 mA/cm2 (77 K, sf) was obtained in the YBCO film grown on the CeO2 technical substrate deposited under optimized deposition conditions, which is rather comparable with that on the LaAlO3 single crystal. TEM cross‐sectional observation reveals that the enhanced Jc (B) properties of the YBCO film are mainly contributed by high density of short stacking faults. This work demonstrates the feasibility of FF‐MOD to fabricate high‐performance YBCO films on the CeO2‐buffered technical substrate.
Spatial segregation between immatures and adults in a pelagic seabird suggests age‐related competition
Authors: Pettex Emeline , Lambert Charlotte , Fort Jérôme , Dorémus Ghislain , Ridoux Vincent 
Published: March 2019

Individual competitiveness conditions access to resources when they are limited. Immature individuals that are less skilled than adults have to adapt their foraging strategies to survive. Among strategies to reduce competition, spatial segregation has been widely demonstrated. However, the use of spatial segregation by immatures to limit intra‐specific competition with adults has rarely been tested.In this study, we investigated and compared habitat preferences and distributions of free‐ranging immature and breeding adult northern gannets Morus bassanus in order to determine whether they compete for similar habitats during the year, and if this results in a spatial segregation between birds of different age groups.Based on > 66 000 km of aerial surveys conducted in the North‐East Atlantic Ocean during winter and summer 2012, habitats selected by immatures and adult birds were modelled independently, linking gannet density to a set of oceanographic and physiographic predictors. Their large‐scale seasonal distribution was then predicted.We found that gannets displayed a strong season‐dependent competition between immatures and adults, as a consequence of immatures and adults using similar habitats in both summer and winter. During summer, when adults are constrained by reproduction, both groups were spatially highly segregated despite similar habitat preferences (thermal fronts), with youngest individuals selecting habitats out of range of central‐place foragers, highlighting intra‐specific competition. Contrastingly during winter, when reproductive constraints disappear, immature and adult distributions largely overlapped.Our study provides new insights into the role played by age, foraging experience and reproductive constraints on the distribution of marine predators. More specifically, these results highlight in seabirds how the youngest fraction mitigates, through spatial segregation, the competition with experienced adults, and suggest a progressive strategy along the maturation process.
The effects of cucurbitacin E on GADD45β‐trigger G2/M arrest and JNK‐independent pathway in brain cancer cells
Authors: Cheng An‐Chin , Hsu Yi‐Chiang , Tsai Chiang‐Chin 
Published: March 2019

AbstractCucurbitacin E (CuE), an active compound of the cucurbitacin family, possesses a variety of pharmacological functions and chemotherapy potential. Cucurbitacin E exhibits inhibitory effects in several types of cancer; however, its anticancer effects on brain cancer remain obscure and require further interpretation. In this study, efforts were initiated to inspect whether CuE can contribute to anti‐proliferation in human brain malignant glioma GBM 8401 cells and glioblastoma‐astrocytoma U‐87‐MG cells. An MTT assay measured CuE's inhibitory effect on the growth of glioblastomas (GBMs). A flow cytometry approach was used for the assessment of DNA content and cell cycle analysis. DNA damage 45β (GADD45β) gene expression and CDC2/cyclin‐B1 disassociation were investigated by quantitative real‐time PCR and Western blot analysis. Based on our results, CuE showed growth‐inhibiting effects on GBM 8401 and U‐87‐MG cells. Moreover, GADD45β caused the accumulation of CuE‐treated G2/M‐phase cells. The disassociation of the CDC2/cyclin‐B1 complex demonstrated the known effects of CuE against GBM 8401 and U‐87‐MG cancer cells. Additionally, CuE may also exert antitumour activities in established brain cancer cells. In conclusion, CuE inhibited cell proliferation and induced mitosis delay in cancer cells, suggesting its potential applicability as an antitumour agent.
Acetaminophen Safety: Risk of Mortality and Cardiovascular Events in Nursing Home Residents, a Prospective Study
Authors: Girard Philippe , Sourdet Sandrine , Cantet Christelle , de Souto Barreto Philipe , Rolland Yves 
Published: March 2019

BACKGROUNDAcetaminophen is the most widely used analgesic today. A recent systematic review found increased adverse events and mortality at therapeutic dosage. Our aim was to challenge these results in a large sample of older adults living in nursing homes (NHs).DESIGNProspective study using data from the Impact of Educational and Professional Supportive Interventions on Nursing Home Quality Indicators project (IQUARE), a multicenter, individually tailored, nonrandomized controlled trial in NHs across southwestern France.SETTING/PARTICIPANTSWe studied data from 5429 participants living in 175 NHs (average age, 86.1 ± 8.1 years; 73.9% women).MEASUREMENTSAll prescriptions obtained at baseline were analyzed by a pharmacist for acetaminophen use as stand‐alone or associated. Myocardial infarction (MI) and strokes were reported from participants' medical records at 18‐month follow‐up. Dates of death were obtained. Data collection was done through an online questionnaire at baseline and at 18 months by NH staff. Analyses were realized in our total population and a population matched on propensity score of acetaminophen intake. Six models were run for each outcome.RESULTSA total of 2239 participants were taking, on average, 2352 ± 993 mg of acetaminophen daily. Results for mortality were: hazard ratio (HR) = 0.97 (95% confidence interval [CI] = 0.86‐1.10). No associations between acetaminophen intake and the risk of mortality or MI were found. In one of our models, acetaminophen intake was associated with a significant increased risk of stroke in diabetic subjects (OR = 3.19; 95% CI = 1.25‐8.18; P = .0157). [Correction added March 16, 2019, after first publication online. In the previous sentence, “HR” was mistakenly used instead of “OR”.]CONCLUSIONDespite old age, polypharmacy, and polymorbidity, acetaminophen was found safe for most, but not all, of our NH study population. Pain management in NHs is a health priority, and acetaminophen remains a good therapeutic choice as a first‐line analgesic. More studies are needed on older diabetic patients.
Maternal care activates the ventral tegmental area but not dopaminergic cells in the rat
Authors: Caba Mario , Melo Angel I. , Fleming Alison , Meza Enrique 
Published: March 2019

The ventral tegmental area (VTA), together with the preoptic area, is part of a neural circuit necessary for the expression of maternal behaviour (MB); destruction of either area disrupts MB in postpartum rats. Central to the proposal of VTA activation are dopaminergic cells, for which the cell bodies lie in the VTA and project to forebrain structures. This mesolimbic system is a motivational circuit involved in rewarding behaviours such as sex and MB. Despite their recognised importance, surprisingly, unlike the preoptic area, there are no anatomical descriptions of the pattern of VTA activation or of the dopaminergic cell activation, specifically in relation to MB in the rat. In the present study, we explore the possible activation (as indicated by Fos protein via immunohistochemistry) of the anterior and medial portions of the VTA and in the dopaminergic cells in these regions, as well as in the medial preoptic area, in lactating rats, at postpartum day 7 (after a 12‐hour mother/pups separation), and in dioestrous females. After 12 hours, mothers were perfused at that moment or after a 90 minutes of interaction, or not, with their pups. We found a strong significant Fos induction in both the preoptic area and in the anterior portion of VTA in dams that interacted with their pups. The number of dopaminergic cells that coexpressed Fos did not differ across groups. Additionally, we determined Fos and GABA colocalisation in the anterior part of the VTA and found dense GABAergic processes, possibly varicosities, in the area of increased Fos expression. The results of the present study support a proposed GABAergic pathway from medial preoptic area to VTA cells, critical for the expression of MB. Future experiments are warranted to explore the neurochemical identity of the Fos and no‐Fos expressing cells that are recipients of GABAergic processes in the VTA, aiming to better understand the neural circuitry of the VTA in relation to MB.