bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Housing Enabler instrument: Assessing threats to reliability and validity
Authors: Norin Lizette , Iwarsson Susanne , Haak Maria , Slaug Björn 
Published: June 2018

Introduction The Housing Enabler instrument, designed to measure housing accessibility, has not been used in samples with long-standing spinal cord injury. We aimed to investigate potential threats to the reliability and validity of the instrument when used among older adults with spinal cord injury. Method Cross-sectional data from the Swedish Aging with Spinal Cord Injury Study ( N = 123, injury levels C1–L5) were utilised. The potential effect on the reliability and content validity of the House Enabler was qualitatively considered and reviewed in an iterative evaluation procedure. To analyse the potential effect on construct validity, simulations adjusting accessibility problem scores for housing adaptations and use of mobility devices were conducted. Findings Considerable threats to the reliability and content validity of the Housing Enabler were identified. The simulated analysis of construct validity showed a modest overall effect on the accessibility problem scores, although this was substantial in some individuals. Conclusion Data collection and analyses of housing accessibility with the Housing Enabler in samples characterised by high frequencies of housing adaptations and/or use of mobility devices (such as powered wheelchairs) require particular attention. Further studies are needed to propose optimisation of the instrument for use in such contexts, followed by psychometric testing to maintain reliability and validity.
Investigation of Plasma Inflammatory Profile in Diabetic Patients With Abdominal Aortic Aneurysm: A Pilot Study
Authors: Lareyre Fabien , Moratal Claudine , Chikande Julien , Jean-Baptiste Elixène , Hassen-Khodja Réda , Neels Jaap , Chinetti Giulia , Raffort Juliette 
Published: June 2018

Introduction: Clinical studies have unraveled a negative association between diabetes and abdominal aortic aneurysm (AAA), but the mechanisms involved are still poorly understood. The aim of this study was to determine whether diabetic patients with AAA had a distinct plasma inflammatory profile compared to nondiabetic patients. Methods: Plasma samples were obtained from 10 diabetic patients with AAA and 10 nondiabetic patients with AAA. The relative protein expression of 92 inflammatory-related human protein biomarkers was assessed by proximity extension assay technology using Proseek Multiplex Inflammation I kit (Olink). Results: Clinical characteristics were similar in diabetic patients with AAA compared to nondiabetic patients with AAA, the median ages being 67 and 73 years, respectively ( P = .61). The AAA diameters were, respectively, 50 and 49 mm ( P = .72). Among the 92 markers screened, 67 (72.8%) were detected in all samples. Diabetic patients had significantly lower protein expression of C-C motif chemokine 19 (CCL19) and C-C motif chemokine 23 (CCL23; 542.3 vs 980.3, P = .01 and 1236 vs 1406, P = .04, respectively). They tended to have higher expression of tumor necrosis factor ligand superfamily member 14 (TNFSF14) compared to controls (14.6 vs 10.8, P = .05). Conclusion: Diabetic patients with AAA differentially expressed CCL19, CCL23 and TNFSF14 in plasma compared to nondiabetic patients with AAA. Further studies are required to determine whether the markers identified could play a role in the negative association between diabetes and AAA pathogenesis.
Safety of nintedanib added to pirfenidone treatment for idiopathic pulmonary fibrosis
Authors: Flaherty Kevin R. , Fell Charlene D. , Huggins J. Terrill , Nunes Hilario , Sussman Robert , Valenzuela Claudia , Petzinger Ute , Stauffer John L. , Gilberg Frank , Bengus Monica , Wijsenbeek Marlies 
Published: June 2018

We assessed safety and tolerability of treatment with pirfenidone (1602–2403 mg·day−1) and nintedanib (200–300 mg·day−1) in patients with idiopathic pulmonary fibrosis (IPF).This 24-week, single-arm, open-label, phase IV study (ClinicalTrials.govidentifierNCT02598193) enrolled patients with IPF with forced vital capacity % pred ≥50% and diffusing capacity of the lung for carbon monoxide % pred ≥30%. Before initiating nintedanib, patients had received pirfenidone for ≥16 weeks and tolerated a stable dose of ≥1602 mg·day−1for ≥28 days. The primary end-point was the proportion of patients who completed 24 weeks of combination treatment on pirfenidone (1602–2403 mg·day−1) and nintedanib (200–300 mg·day−1). Investigators recorded treatment-emergent adverse events (TEAEs), attributing them to pirfenidone, nintedanib, both or neither.89 patients were enrolled; 73 completed 24 weeks of treatment (69 meeting the primary end-point) and 16 discontinued treatment prematurely (13 due to TEAEs). 74 patients had 418 treatment-related TEAEs, of which diarrhoea, nausea and vomiting were the most common. Two patients had serious treatment-related TEAEs.Combined pirfenidone and nintedanib use for 24 weeks was tolerated by the majority of patients with IPF and associated with a similar pattern of TEAEs expected for either treatment alone. These results encourage further study of combination treatment with pirfenidone and nintedanib in patients with IPF.
Serotonergic antidepressant use and morbidity and mortality among older adults with COPD
Authors: Vozoris Nicholas T. , Wang Xuesong , Austin Peter C. , Stephenson Anne L. , O'Donnell Denis E. , Gershon Andrea S. , Gill Sudeep S. , Rochon Paula A. 
Published: June 2018

We evaluated the relationship between new selective serotonin reuptake inhibitor (SSRI) or serotonin–noradrenaline reuptake inhibitor (SNRI) drug use and respiratory-related morbidity and mortality among older adults with chronic obstructive pulmonary disease (COPD).This was a retrospective population-based cohort study using heath administrative data from Ontario, Canada. Individuals aged ≥66 years, with validated, physician-diagnosed COPD (n=131 718) were included. New SSRI/SNRI users were propensity score matched 1:1 to controls on 40 relevant covariates to minimise potential confounding.Among propensity score matched community-dwelling individuals, new SSRI/SNRI users compared to non-users had significantly higher rates of hospitalisation for COPD or pneumonia (hazard ratio (HR) 1.15, 95% CI 1.05–1.25), emergency room visits for COPD or pneumonia (HR 1.13, 95% CI 1.03–1.24), COPD or pneumonia-related mortality (HR 1.26, 95% CI 1.03–1.55) and all-cause mortality (HR 1.20, 95% CI 1.11–1.29). In addition, respiratory-specific and all-cause mortality rates were higher among long-term care home residents newly starting SSRI/SNRI drugsversuscontrols.New use of serotonergic antidepressants was associated with small, but significant, increases in rates of respiratory-related morbidity and mortality among older adults with COPD. Further research is needed to clarify if the observed associations are causal or instead reflect unresolved confounding.
Hyperactivity precedes conduct problems in preschool children: a longitudinal study
Authors: Gustafsson Berit M. , Danielsson Henrik , Granlund Mats , Gustafsson Per A. , Proczkowska Marie 
Published: June 2018

BackgroundExternalising problems are among the most common symptoms of mental health problems in preschool children.AimsTo investigate the development of externalising problems in preschool children over time, and the way in which conduct problems are linked to hyperactivity problems.MethodIn this longitudinal study, 195 preschool children were included. Latent growth modelling of conduct problems was carried out, with gender and hyperactivity at year 1 as time-invariant predictors.ResultsHyperactivity was a significant predictor for the intercept and slope of conduct problems. Children with more hyperactivity at year 1 had more conduct problems and a slower reduction in conduct problems. Gender was a significant predictor for the slope of conduct problems.ConclusionsChildren with more initial hyperactivity have less of a reduction in conduct problems over time. It is important to consider the role of hyperactivity in studies of the development of conduct problems.Declaration of interestNone.
Perioperative Blood Management, Red Cell Recovery (Cell Salvage) Practice in an Australian Tertiary Hospital: A Hospital District Clinical Audit
Authors: Forrest Elizabeth A. , Togo Penny , Kan Alistair G. , De Cruz Shaun E. 
Published: June 2018

BACKGROUND:
Data on red cell recovery (cell salvage) utilization in Australia are limited and national guidance is based on a single Australian audit conducted at a hospital that excludes cardiothoracic surgery. This clinical audit aimed to analyze the utility of red cell recovery at a tertiary health care facility which includes cardiothoracic surgery. Secondary aims of this study were to identify specific surgical procedures in which red cell recovery is most beneficial and to quantify this benefit.

METHODS:
Data were collected retrospectively on all adult red cell recovery surgical cases conducted at a 2-campus health care facility over a 2-year period. Case demographic data, including surgical procedure, red blood cell return, and hematocrit levels, were collated and analyzed against national cell salvage guidelines. Average return per procedure was collated into a red cell recovery benefit analysis.

RESULTS:
A total of 471 red cell recovery cases for 85 surgical procedures met inclusion criteria. Of the 7 surgical subspecialties utilizing red cell recovery, orthopedics utilized the most cases (22.9%, n = 108), followed by urology (19.1%, n = 90) and cardiothoracic surgery (18.3%, n = 86). Radical retropubic prostatectomy (11.7%), revision (7.6%), and primary (6.6%) total hip replacement were the most utilized procedures. Red cell recovery use had a 79% compliance rate with national guidelines. Vascular surgery and urology had the highest average return at 699 mL (interquartile range, 351–1127; CI, 449–852) and 654 mL (interquartile range, 363–860; CI, 465–773), respectively.

CONCLUSIONS:
Overall, our center demonstrated good compliance with national red cell recovery guidelines. This audit adds to the existing data on red cell recovery practice in Australia and provides a benefit-specific surgical procedure guideline that includes cardiothoracic surgery.
EB1 contributes to microtubule bundling and organization, along with root growth, in Arabidopsis thaliana
Authors: Molines Arthur T. , Marion Jessica , Chabout Salem , Besse Laetitia , Dompierre Jim P. , Mouille Grégory , Coquelle Frédéric M. 
Published: June 2018

ABSTRACT
Microtubules are involved in plant development and adaptation to their environment, but the sustaining molecular mechanisms remain elusive. Microtubule-end-binding 1 (EB1) proteins participate in directional root growth in Arabidopsis thaliana. However, a connection to the underlying microtubule array has not been established yet. We show here that EB1 proteins contribute to the organization of cortical microtubules in growing epidermal plant cells, without significant modulation of microtubule dynamics. Using super-resolution stimulated emission depletion (STED) microscopy and an original quantification approach, we also demonstrate a significant reduction of apparent microtubule bundling in cytoplasmic-EB1-deficient plants, suggesting a function for EB1 in the interaction between adjacent microtubules. Furthermore, we observed root growth defects in EB1-deficient plants, which are not related to cell division impairment. Altogether, our results support a role for EB1 proteins in root development, in part by maintaining the organization of cortical microtubules.
This article has an associated First Person interview with the first author of the paper.
La Economía Política Internacional en el campo de las Relaciones Internacionales argentinas
Authors: Deciancio Melisa 
Published: June 2018

Este trabajo busca responder a la pregunta acerca de cuáles han sido los principales aportes de la Economía Política Internacional (EPI) al devenir histórico del campo intelectual de las Relaciones Internacionales (RI) en Argentina. El Trabajo se inscribe en dar respuesta a una pregunta más amplia acerca del proceso de constitución del campo de las ri como disciplina académica autónoma en Argentina. Se indagará sobre los aportes realizados por la epi, especialmente, el estructuralismo latinoamericano y el desarrollismo, como espacios de producción teórica y conceptual desde donde se construye parte del pensamiento sobre la realidad internacional. El objetivo del trabajo girará en torno a reconstruir la agenda de epi y su contribución al desarrollo de las ri argentinas mediante la observación y análisis de los principales autores y conceptos, las instituciones que han servido como espacios de producción de conocimiento y las revistas especializadas que actuaron como plataformas para la difusión de temas e ideas.
Sociabilidad online en grupos juveniles de Facebook en Chile: un estudio mediante etnografía virtual.
Authors: Mendoza Riquelme Catalina , Ganter Solís Rodrigo , Basulto Gallegos Oscar 
Published: June 2018

Este artículo surge desde una investigación exploratoria realizada durante el año 2016. Dicho estudio tuvo por objetivo conocer las formas de sociabilidad construidas por un grupo juvenil de Facebook chileno denominado “NRN”[1]. Para ello, a través de una etnografía virtual[2], se identificaron algunos rasgos, dinámicas y modos de funcionamiento practicados por sus miembros. Entre los hallazgos se constató que la forma más frecuente para socializar era la publicación de un conjunto de autofotos o selfies, siguiendo una actividad diaria establecida por los administradores del grupo. El análisis de una selección de las publicaciones recolectadas reveló que las/os jóvenes comparten un repertorio de prácticas corporales performativas para lograr una valoración positiva de su imagen dentro de la comunidad.[1] NRN es la sigla asignada para ocultar el verdadero nombre de la comunidad investigada y, con ello, proteger la identidad de sus miembros. [2]La presente publicación se enmarca dentro de la discusión de resultados del proyecto FONDECYT nº 11140866.
Implementation of RFID Technology at Defence Science Library, DESIDOC : A Case Study
Authors: Nisha Faizul 
Published: June 2018

<p>Radio Frequency IDentification (RFID) as a tool is being used for the better governance and management of libraries. A RFID system offers a complete package from security, theft detection, tracking, monitoring, inventory control, and act as an expedient in books circulation or charging and discharging of books; and, lessens the burden of librarians, who could be better redeployed to other productive activities in the service of the readers. RFID technology was implemented in Defence Science Library, Defence Scientific Information &amp; Documentation Centre (DESIDOC), Delhi, in 2013. The study describes the process of implementation of RFID system in the Defence Science Library, at DESIDOC. It provides an overview of the work to implement the RFID system including the philosophy or the background or thought process that had gone into deciding in its implementation, the various features, technical specification of the library automation software and system itself. The constraints faced during the data migration and the visible advantages from the users’ perspective vis-à-vis manual operation are also covered. The study concludes that implementation of RFID technology has brought a bouquet of benefits to librarians, the staff and scientists or user of the Library. </p>
Commemorative Issue of DESIDOC Journal of Library and Information Technology on DRDO@60
Authors: Suri Alka 
Published: June 2018

<h3> DESIDOC Journal of Library and Information Technology (DJLIT) started in 1980 as DESIDOC Bulletin—a fourpage newsletter—basically to publish the activities of the DESIDOC. In the late 1980s, computers started revolutionising the working culture and information science and technology was the buzzword. The field of library and information science was also not left unchanged. </h3><p> In 1992, the Bulletin was renamed as DESIDOC Bulletin of Information Technology (DBIT). Information technology also changed the publishing scenario. Internet made dissemination of information easier and writers their own publishers. In 2006, Editorial Board of the Bulletin was revamped to include experienced LIS professionals; peer-evaluation of papers, which was earlier limited and institutional, was started involving professionals and academicians from outside; and the secondary information in DBIT was done away with. In 2008, DBIT became a primary research journal and was rechristened as DESIDOC Journal of Library and Information Technology (DJLIT). Since then, only primary research work, after peer-evaluation, is accepted for publication. Thematic issues on contemporary subjects have been brought out along with general issues. And in the same year, DJLIT adopted Open Journal System—an online journal publication management system. The system helped in fast processing of papers submitted for publication in the journal and access of the journal has become free online for the community. This issue of DJLIT is dedicated to the DRDO@60 includes 5 papers authored by scientists/officers of DRDO and 5 from outside DRDO. Scientists/Officers from DRDO have reported variety of topics in their key research areas. </p>
Trends in E-book Research
Authors: Kumbhar Rajendra 
Published: June 2018

<p>The research intended to identify current trends in research on e-books. Specifically it aimed to know the facets of e-books attended to by the research published during 2016. It also intended to review significant results and their supportive or contradictory nature with reference to each other.</p><p>For this review research literature on e-books was searched from LISA, Emerald, Ebsco, Google Scholar and other databases using the statement ‘e-books OR ebooks’. The query was restricted to journal articles published in English language during January to December 2016. The review finds that the focus of current research on e-books is clearly on usage of e-books. Themes such as e-book collection development and management; search and discovery are also paid more attention to. Usage of e-books by children is emerging as a prominent area of e-book research. Designing of e-books and e-book reading devices are also topics of interest to e-book researchers. Many non-LIS disciplines and professions have interest in researching e-books. </p><p> </p>
Zero Energy Overwinter Storage of Apple Nursery Plants in trans-Himalayan Ladakh, India
Authors: Angmo Phunchok , Chandel Joginder S , Katiyar Anand Kumar , Targais Konchok , Chaurasia O P , Stobdan Tsering 
Published: June 2018

<p>Studies were conducted during 2015 and 2016 to assess the effects of storage conditions on survival of nursery plants in trans-Himalayan Ladakh region. Apple nursery plants raised under warm climatic conditions of Solan (Himachal) were lifted from nurseries in first week of January and stored upto March in cold Ladakh region. Underground cellar-stored plants showed significantly higher plant survival (92 to 94%) than greenhouse-stored plants (37 to 56% survival). Low and constant temperature (-1.5±4.1 to 10.0±1.4ºC) and absence of light inside the cellar were favorable factors for storage of nursery plants. Lower survival rates of greenhouse-stored plants could be attributed to lower and greater fluctuations in temperature (-9.3±1.7to 25.1±1.9ºC) inside the greenhouse. Cellar-stored plants were less subjected to freezing injury as reflected from shoot electrolyte leakage studies. The underground cellar was found effective for overwinter storage of apple nursery plants for 3 to 4 months. The method described is easy and cost-effective, and can be a satisfactory alternative to refrigerated cold storage in trans-Himalayan region with severe winters.<strong></strong></p><p> </p>
Tomato Growth Promotion Induced by Stress Tolerant Phosphate Solubilizing Pseudomonas simiae in Arid trans-Himalaya
Authors: Dolkar Diskit , Dolkar Phuntsog , Stobdan Tsering , Katiyar Anand K 
Published: June 2018

<p><em>Pseudomonas simiae</em> isolated from Seabuckthorn rhizosphere solubilized insoluble phosphate at 4-40ºC, pH 4-12 and in presence of 1-5% salt concentration. The optimum condition was observed at 28ºC, pH 6 and devoid of any salt stress. Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> was solubilized to a great extent than FePO<sub>4</sub> and AlPO<sub>4</sub>. The isolate possess plant growth promoting attributes such as IAA (32 mg l<sup>-1</sup>), siderophore (78%) and HCN (0.1 OD at A<sub>625</sub>) production. Seed bacterization resulted in 30% and 51% enhanced shoot and root length, respectively in tomato seedling. Pot experiments revealed enhanced plant growth in <em>P. simiae</em> treated plants in both green shade net and open field conditions. Fruit yield was 9.8% and 19.8% higher over control in open and shade net condition, respectively. <strong></strong></p>
Sustainable Utilization of Medicinal Plants of Ladakh and Lahaul-Spiti of Trans-Himalaya
Authors: Saxena Shweta , Bhardwaj Ashwani Kumar , Kumar Vikas , Patel Manoj Kumar , Kumar Raj , Chaurasia Om Prakash 
Published: June 2018

<p>Cold arid and high altitude region of the trans-Himalayas (Ladakh &amp; Lahaul-Spiti) is a unique region of the world where all non-native living beings experience noticeably hostile environments that make their survival much challenging compared to their respective natural dwelling niches. The region is characterized by extreme temperature variation, low precipitation mostly in the form of snow, thin atmosphere with high UV-radiation, less oxygen availability, high wind velocity, sparse plant density and fragile ecosystem. Interestingly, these adverse environmental conditions are ideal for the growth of valuable medicinal plants. Like other parts of the Himalaya, Ladakh and Lahaul-Spiti are also the treasure house of several unique medicinal plants which form an indispensable ingredient of local traditional system of medicines especially <em>Sowa Rigpa</em> System (<em>Amchi</em> system of medicine) since ages. </p>
Sequence Characterisation and Genotyping of Allelic Variants of Beta Casein Gene Establishes Native Cattle of Ladakh to be a Natural Resource for A2 Milk
Authors: Sodhi Monika , Kataria R. S. , Niranjan Saket K. , K. Parvesh , Verma Preeti , Swami Shelesh K. , Sharma Ankita , Bharti Vijay K. , Kumar Bhuvnesh , Iqbal M. , Rabgais Stanzen , Kumar Prabhat , Giri Arup , Kalia Sahil , Gagoi Deepak , Sarangi Prabhu Prasad , Mukesh Manishi 
Published: June 2018

Bovine milk is regarded as nature's perfect food due to presence of vital nutrients. However some peptides are generated after proteolytic digestion of β-casein that have opioid properties and may increase the risk of chronic diseases. There are 13 genetic variants of bovine beta-casein; out of these A1 and A2 are the most common in dairy cattle breeds. The A1 and A2 variants differ only at position 67, which is histidine in A1 or proline in A2 milk. Earlier published reports have indicated that A1 β casein could be responsible for several health disorders like diabetes, coronary heart disease etc. while A2 β-casein is generally considered safe for human consumption. In the present study, an effort was made to sequence characterize β casein gene and identify allelic distribution of A1A2 alleles in native cattle of Ladakh region adapted to high altitude and low oxygen condition. The data showed 2 non-synonymous variations in coding region, while 5’UTR was completely conserved. The 3’UTR showed 2 more variations in Ladakhi samples. Further, the genotyping in 85 Ladakhi cattle for A1A2 alleles revealed that in Ladakhi cattle, A2 allele is predominantly present as reported for some of the other Indian breeds. The frequency of A2 allele was 0.90 and frequency of A2A2 genotype was found to be 0.79 in Ladakhi cattle. The present data strongly indicate that local cattle of Ladakh with higher frequency of A2 allele and A2A2 genotype is natural resource for A2 milk. Systematic efforts should be made for long term conservation and genetic improvement of this invaluable genetic resource of Ladakh.