bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transplantation of mesenchymal stem cells genetically engineered to overexpress interleukin-10 promotes alternative inflammatory response in rat model of traumatic brain injury
Authors: Peruzzaro S. T. , Andrews M. M. M. , Al-Gharaibeh A. , Pupiec O. , Resk M. , Story D. , Maiti P. , Rossignol J. , Dunbar G. L. 
Published: January 2019

Abstract
Background
Traumatic brain injury (TBI) is a major cause for long-term disability, yet the treatments available that improve outcomes after TBI limited. Neuroinflammatory responses are key contributors to determining patient outcomes after TBI. Transplantation of mesenchymal stem cells (MSCs), which release trophic and pro-repair cytokines, represents an effective strategy to reduce inflammation after TBI. One such pro-repair cytokine is interleukin-10 (IL-10), which reduces pro-inflammatory markers and trigger alternative inflammatory markers, such as CD163. In this study, we tested the therapeutic effects of MSCs that were engineered to overexpress IL-10 when transplanted into rats following TBI in the medial frontal cortex.

Methods
Thirty-six hours following TBI, rats were transplanted with MSCs and then assessed for 3 weeks on a battery of behavioral tests that measured motor and cognitive abilities. Histological evaluation was then done to measure the activation of the inflammatory response. Additionally, immunomodulatory effects were evaluated by immunohistochemistry and Western blot analyses.

Results
A significant improvement in fine motor function was observed in rats that received transplants of MSCs engineered to overexpress IL-10 (MSCs + IL-10) or MSCs alone compared to TBI + vehicle-treated rats. Although tissue spared was unchanged, anti-inflammatory effects were revealed by a reduction in the number of glial fibrillary acidic protein cells and CD86 cells in both TBI + MSCs + IL-10 and TBI + MSC groups compared to TBI + vehicle rats. Microglial activation was significantly increased in the TBI + MSC group when compared to the sham + vehicle group. Western blot data suggested a reduction in tumor necrosis factor-alpha in the TBI + MSCs + IL-10 group compared to TBI + MSC group. Immunomodulatory effects were demonstrated by a shift from classical inflammation expression (CD86) to an alternative inflammation state (CD163) in both treatments with MSCs and MSCs + IL-10. Furthermore, co-labeling of both CD86 and CD163 was detected in the same cells, suggesting a temporal change in macrophage expression.

Conclusions
Overall, our findings suggest that transplantation of MSCs that were engineered to overexpress IL-10 can improve functional outcomes by providing a beneficial perilesion environment. This improvement may be explained by the shifting of macrophage expression to a more pro-repair state, thereby providing a possible new therapy for treating TBI.
The C677T polymorphism of the methylenetetrahydrofolate reductase gene and susceptibility to late-onset Alzheimer’s disease
Authors: Yi Jian , Xiao Lan , Zhou Sheng-Qiang , Zhang Wen-Jiang , Liu Bai-Yan 
Published: January 2019

Abstract
Folate metabolism makes a crucial contribution towards late-onset Alzheimer’s disease (LOAD). Moreover, methylenetetrahydrofolate reductase (MTHFR) constitutes the primary enzyme of the folate pathway. We hypothesize that there is an association of C677T polymorphism in the MTHFR gene with the susceptibility to LOAD. Previous published research has investigated the link between the MTHFR C677T polymorphisms and LOAD susceptibility; nevertheless, the findings have continued to be not only controversial, but also indecisive. Accordingly, we carried out the present meta-analysis for the assessment of the potential link that exists between the MTHFR C677T polymorphism and the susceptibility to LOAD. Furthermore, we carried out a literature search of the PubMed, EMBASE, Cochrane Library, and WanFang database up to August 10, 2018. The odds ratios (ORs) with the respective 95% confidence interval (95%CI) were put to use for the evaluation of the robustness of the link of the MTHFR C677T polymorphism with the vulnerability to LOAD. All statistical analyses were carried out using STATA 15.0. An aggregate of 14 case-control research works was retrieved, involving 2,467 LOAD patients as well as 2,877 controls. We found that a substantial link exists between C677T polymorphism and LOAD risk in a codominant framework (TC vs. CC: OR=1.22, 95%CI=1.00-1.49, P=0.049). In addition to the stratified analysis based on ethnicity, which suggested that C677T polymorphism was likely linked only to an augmented threat of LOAD in Asians, it did not exist among Caucasians. Furthermore, in the subgroup analysis carried out using APOE ɛ4 status, a substantial increase in the susceptibility to LOAD was detected in APOE ɛ4 carriers as well as non-APOE ɛ4 carriers. In sum, the current meta-analysis revealed that MTHFR C677T polymorphism was associated with susceptibility to LOAD. Further extensive case-control studies are required.
Soziale Determinanten der Aufnahme und Aufrechterhaltung der Sportteilnahme im mittleren und späten Erwachsenenalter
Authors: Jekauc Darko , Wäsche Hagen , Mess Filip , Bös Klaus , Woll Alexander 
Published: January 2019

Zusammenfassung
Vor dem Hintergrund der Diskussion über soziale Ungleichheit wird analysiert, welche Rolle soziale Determinanten in den Prozessen der Aufnahme und der Aufrechterhaltung der Sportteilnahme spielen. In der vorliegenden Längsschnittstudie wurden 481 Personen im Anfangsalter zwischen 33 und 56 Jahren (M = 45.0; SD = 7.5) zu vier Messzeitpunkten (1992, 1997, 2002 und 2010) bezüglich ihres Sportverhaltens befragt. In der Aufnahmephase haben Frauen eine mehr als dreimal höhere Wahrscheinlichkeit sportlich aktiv zu werden als Männer. Dieser Einfluss wird durch die familienbezogenen Variablen (Anzahl der Kinder und Anzahl der Personen im Haushalt) mediiert, was die Bedeutung der vermittelnden Instanz Interaktionskontext unterstreicht. In der Aufrechterhaltungsphase spielt der Sozialstatus eine wichtige Rolle, wobei dieser Einfluss nicht von den zeitbezogenen Arbeitsbelastungen mediiert wird.
Issues around the FIFA World Cup 2018 in Russia: A showcase of how sports and politics mix
Authors: Reiche Danyel 
Published: January 2019

Summery
The 2018 FIFA World Cup in Russia was another demonstration in how sports and politics mix. In protest of Russian politics, few leaders from Western countries attended. For this World Cup, public resources were misused in that half of the stadiums built in Russia were left as “white elephants” with no longterm use. The tournament in Russia marked a shift from the West to the East with sponsors from authoritarian countries having saved the business model of FIFA. The policy of fining misconduct during the World Cup showed FIFA’s commitment to protect its remaining sponsors while proclaimed values, such as fighting racism, were of minor importance. The case of Iranian women using the opportunity not only to attend their national team’s games in Russia but also to advocate for the right of women to enter stadiums in Iran showed that football can also be an agent for social change. In two countries (Germany, United States), World Cup matches hosted female commentators on television for the first time. In Belgium, players operated largely above the Flemish-Walloon divide. The article concludes by comparing the last World Cup in Russia with the next one in Qatar and identifying topics for future research.
A Fiber Bragg Grating–Based Inclinometer Fabricated Using 3-D Printing Method for Slope Monitoring
Authors: Hong Chengyu , Zhang Yifan , Abro Zamir Ahmed 
Published: January 2019

Abstract
A new temperature-insensitive inclinometer was fabricated using a 3-D printing method based on fiber Bragg grating (FBG) sensors. This new tilt sensor is characterized by its light weight, immunity to electromagnetic interference (EMI) small size, quick prototyping, and cost effectiveness. FBG sensors were directly inscribed into polylactic acid, which was also used for fabricating all different parts of tilt sensors. Calibration tests of this new tilt sensor were performed in laboratory to examine its measurement performance. Measurement sensitivity of 0.012 nm/° and a maximum tilt angle of 25° of the FBG inclinometer was approached in the calibration experiment. The measured tilt angles were validated by theoretical angles calculated in terms of all physical parameters of internal functional parts of the inclinometer. A monitoring test of a sandy slope model using this new tilt sensor was conducted in laboratory. Finite element analysis was also used to examine the mechanical behavior of the slope model under different loading levels. Monitoring test results indicate that the FBG-based tilt sensor presented no obvious change before a surcharge load approaching 0.245 kN but exhibited step-by-step rise in tilt angle afterward, achieving a maximum tilt angle of around 6°. Horizontal displacement, which was calculated in terms of the tilt sensor at different loading levels, was found to agree fairly well with the displacement data from both finite element analysis and displacement transducers.
Motor Abilities: Description of Motor Preparedness of 7th-9th Grade Girls of Village School
Authors: Semko Yu. S. 
Published: January 2019

The study purpose is to determine the age-related peculiarities of motor preparedness of 7th-9th grade girls of a village school.
Materials and methods. The study involved 7th grade girls (n=9), 8th grade girls (n=9), 9th grade girls (n=12). The children and their parents were fully informed about all the features of the study and gave their consent to participate in the experiment. The following research methods were used to solve the tasks set: analysis of scientific and methodological literature, pedagogical testing and methods of mathematical statistics for processing research results.
Results. The 7th-9th grade girls show statistically significant changes in the results of the following tests: test 1 “Shuttle run 4×9 m” (t=5.108, P=0.001); test 3 “Arms’ bending and straightening in a hanging position” (t=-3.448, P=0.003); test 4 “Bent-arm hang” (t=2.216, P=0.047); test 5 “Long jump” (t=-2.161, P=0.044); test 6 “Evaluation of time parameters 5 seconds” (t=-2.639, P=0.016); test 9 “Stange’s test” (t=-4.521, P=0.001); test 10 “Genci’s test” (t=-4.662, P=0.001); test 11 “Serkin’s test 1” (t=-3.616, P=0.002), and test 12 “Serkin’s test 2” (t=-2.400, P=0.027). The 9th grade girls show the best results in tests 1, 2, 5, 6, 9-12. The 7th grade girls show the best results in test 4.
Conclusions. The 7th-9th grade girls show a positive dynamics of the functional condition of respiratory and circulatory functions. The level of motor and functional preparedness of the village school 7th-9th graders is assessed as average.
Pendidikan karakter peduli lingkungan (studi kasus di sekolah menengah Assalihiyah, Thailand)
Authors: Sholikhah Titik Isniatus 
Published: January 2019

Kerusakan lingkungan hidup yang terjadi adalah karena ulah tangan manusia itu sendiri yaitu kurangnya rasa peduli lingkungan yang dimiliki. Oleh karenanya, nilai-nilai budaya peduli lingkungan ini akan lebih baik jika ditanamkan sejak dini pada peserta didik. Penelitian ini bertujuan untuk mengetahui pendidikan karakter peduli lingkungan di Sekolah Menengah Assalihiyah Thungphla, Khokpho, Pattani, Thailand Selatan beserta faktor-faktor yang menjadi penunjang dan penghambat dalam penanaman karakter peduli lingkungan pada siswa. Jenis penelitian ini adalah penelitian lapangan (field research) dan bersifat deskriptif kualitatif. Pengumpulan data dalam penelitian ini melalui wawancara, observasi, dan dokumentasi. Hasil penelitian menunjukkan bahwa pertama, pelaksanaan pendidikan karakter peduli lingkungan di Sekolah Menengah Assalihiyah dititikberatkan pada masalah menjaga kebersihan lingkungan yang berdasarkan hadits Rasulullah Saw. yaitu kebersihan merupakan bagian dari iman. Penanaman karakter peduli lingkungan ini termasuk realisasi program Green Environment seperti yang berlaku di negara Indonesia. Pendidikan karakter peduli lingkungan diberikan dengan berbagai model salah satunya keteladanan. Kedua, faktor penunjang pendidikan karakter peduli lingkungan di sini adalah kebiasaan siswa di rumah yang rajin dan peran serta guru. Sedangkan faktor penghambatnya adalah sifat malas siswa dan kondisi luar masyarakat yang berbeda. The environmental damage that occurs is because of the human hands themselves, namely the lack of a sense of care for the environment they have. Therefore, cultural values that care about the environment will be better if they are instilled early on in the students. This study aims to find out the environmentally caring character education in Assalihiyah Thungphla Middle School, Khokpho, Pattani, Southern Thailand along with the factors that are supporting and inhibiting the cultivation of environmental caring characters in students. This type of research is field research and is qualitative descriptive. Data of this study were collected through interviews, observation, and documentation. The results showed that the implementation of character education in Assalihiyah Middle School was focused on the problem of maintaining environmental cleanliness. The cultivation of character caring for the environment includes the realization of the Green Environment program as applicable in Indonesia. Environmental care character education is provided with various models, one of which is exemplary. The supporting factors for character education in the environment here are the habit of diligent home students and the participation of teachers, while the inhibiting factor is the laziness of students and different conditions outside the community.
Argumentointia monenlaisissa konteksteissa
Authors: Lahti Emmi 
Published: January 2019

Arvioitu teos
Cornelia Ilie & Giuliana Garzone (toim.): Argumentation across communities of practice. Multi-disciplinary perspectives. Argumentation in Context 10. Amsterdam: John Benjamins Publishing Company 2017. 345 s. isbn 978-90-272-1127_9.
Guideline-based Decision Support Systems: Concepts, Technical Considerations and Challenges
Authors: Safdari Reza , Aghamohammadi Asghar , Langarizadeh Mostafa , Sepehri Fateme 
Published: January 2019

Introduction: Guideline-based Decision Support Systems helps clinician to choose the best treatment in specific clinical situations. Since it is difficult for doctors to Remember all effective measures of diagnosis and the average visit time for each patient less than 20 minutes, so integrate guideline with clinical decision support system help doctors to choose the best course of treatment in the clinical setting.Material and Methods: This paper is a literature review and have implication to clinical guidelines concepts, guideline-based decision support system, challenges and technical considerations.Results: The best and fastest approach to use of guideline is their integration with hospital information system or electronic health record. The development of these systems require careful design of clinical guidelines development, decision models, and reusable software components and appropriate computing infrastructures in the clinical environment. Currently, XML is the best choice for packaging data and information sharing, but there isn't a specific standard that fully provide interoperability with EHR.Conclusion: Ease of learning is one of the main issues in the guideline based EHR. Guideline must be designed that their use is simple so developers. Clinical guidelines integration with information systems and electronic medical records lead to increase adherence to clinical guidelines in health care, quality of care provided to patients, ensuring patient safety and reduce costs.
ATD-nin ilanvurmalar zamanı ilk yardım, profilaktika və müalicə üzrə metodik vəsaiti
Authors: Əfəndiyev İ. N. , Seyidov N. Z. , Bünyatova S. N. , Mirzəyev S. S. 
Published: January 2019

Bu metodik vəsait həm mülki həkimlər, həm də problemin aktuallığı nəzərə alınaraq hərbi həkimlər üçün nəzərdə tutulmuşdur. Məlum olduğu kimi, Azərbaycanda ilanvurmalar, xüsusilə zəhərli ilan dişləmələri hər həkimin gündəlik praktikasında rast gəlinə bilən bir yayılmış patologiya deyildir. Tamamilə təbiidir ki, bu patologiyalar üzrə həkimlərin nəzəri və praktiki hazırlığı arzuolunan səviyyədə deyildir. İlanvurmaların müasir səviyyədə diaqnostika və müalicəsinin aparılması üçün ilk əvvəl ilanların növlərini yaxşı tanımaq, ayırd etmək və zəhərin toksik təsirini bilmək lazımdır. Ona görə də, metodik vəsaitdə olan məlumatlar bu patologiya ilə qarşılaşa biləcək tibb işçilərinə maraqlı və faydalı olacaqdır. Metodik vəsait ilkin səhiyyə səviyyəsində çalışan həkimlər, toksiko-logiya, reanimasiya və intensiv terapiya, cərrahiyyə şöbələrinin və bölgələrdə yerləşən hərbi hissə həkimləri üçün nəzərdə tutulmuşdur. Metodik vəsaitin məqsədi Azərbaycanda ilanvurmaların diaqnostikası, ilk yardımı, müalicəsi və profilaktikası ilə bağlı sübutlu təbabət prinsiplərinə əsaslanmış dəqiq tövsiyyələrin işlənib hazırlanmasıdır.
Un poco de la Historia de la Mina de Dificultad
Authors: Rodriguez Jose Ulises 
Published: January 2019

Al hablar de Real del Monte, lo primero que nos viene a la mente es: un lugar hermoso, histórico y cultural, sin duda lo es.
Pero es un pueblo que aún guarda muchos secretos, y mucho de esos secretos están en las minas que explotaron la Veta Vizcaína, la gran veta que por 200 años fue explotada y que ahora dichas minas son “Patrimonio Histórico de la Nación”, sin lugar a duda se ganaron un lugar en la historia de México y del Mundo, ya que la gran veta Vizcaína es una de las más grandes y más provechosas en la historia de la minería mundial.
Análisis de Regresión y Correlación Lineal
Authors: Leal-Cornejo Fabiola , López-García Robert E. , Martínez-Montiel Mónica G. , Tapia-Castillo Delia I. , León-Vázquez Irma I. de 
Published: January 2019

La regresión y la correlación se emplea en diversas disciplinas como la sociología, la biomedicina, las ingenieras, la economía, entre otras., están estrechamente relacionadas comprendiendo una forma de estimación, se suelen utilizar para resolver una gran cantidad de problemas, mientras que la regresión se encarga de la relación que hay entre variables, la correlación mide el grado de relación lineal entre dos o más variables, dando como resultado la fuerza y sentido de la relación.
En otras fuentes consultadas, nos dice que el análisis de correlación da como resultado un número que resumen el grado de la correlación entre dos variables, y el análisis de regresión da una ecuación matemática que describe dicha relación, los datos que son necesarios provienen de observaciones de variables relacionadas.
Para hacer una correlación se requiere saber de qué tipo son las variables, sean cuantitativas o cualitativas, pues se utilizaron distintos métodos, las ventajas de la correlación tienen su propio lenguaje interpretado.
En el caso de la regresión, para que el resultado sea correcto es necesario tomar hacer una selección adecuada de las variables, pues si tomamos variables que no tengan ninguna relación con la práctica nos dará como resultado ilógico, es decir no tendrá sentido, esta es una herramienta útil para la planeación.
También se le denomina análisis de regresión a cualquier método estadístico que establezca una ecuación permitiendo estimar el valor desconocido de una variable a partir del valor conocido de una o más variables, este término fue utilizado por primera vez en 1877 por el estadístico inglés Francis Galton, en base a un estudio que realizó, demostrando que la altura de los hijos altos, tendía a retroceder, o regresar. Esta siempre se desarrolla en una ecuación de estimación, relacionando las variables desconocidas con las variables conocidas.
Casi siempre en el análisis de correlación con el análisis de regresión se utilizan en conjunto para medición de la eficacia que la línea de regresión explica la variación de la variable dependiente, Y.
Ultrasound-guided liver biopsy and drainage
Authors: Prueksapanich Piyapan 
Published: January 2019

Despite the presence of non-invasive alternatives, liver biopsy remains the indispensable standard for the diagnosis of many liver diseases, and also provides information for prognostic evaluation and clinical therapeutic decision. Ultrasound guidance has become standard practice for percutaneous liver biopsy and also other percutaneous biliary interventions. Ultrasound offers a number of advantages including its real-timed guidance, lack of radiation exposure, inexpensiveness and the ability to perform at the bedside. In this review, I discuss the indications, contraindications, equipment and procedure, possible complications and post-procedural care for the ultrasound-guided hepatic procedures including percutaneous liver biopsy, percutaneous transhepatic biliary drainage, percutaneous cholecystostomy, percutaneous catheter drainage and needle aspiration.

Figure 1 การใช้คลื่นเสี่ยงความถี่สูงนำทางเข็มระหว่างการเจาะชิ้นเนื้อตับ
Typical features of liver Histology in autoimmune hepatitish
Authors: Chalermsuksant Nalerdon , Angkathunyakul Napat , Intaraprasong Pongphob 
Published: January 2019

Autoimmune hepatitis is a chronic progressive liver disease which may present as acute hepatitis, chronic hepatitis or even cirrhosis. We report a case of 67-year-old female with diabetic mellitus and hyperlipidemia present with progressive fatigue for one year. Her liver function tests showed hepatocellular injury pattern, elevated serum IgG level and positive ANA 1:320 in homogeneous pattern. Her abdominal ultrasound revealed normal liver parenchyma and no bile duct dilatation. The liver biopsy showed interface hepatitis, lymphoplasmacytic infiltration, bridging necrosis, emperipolesis and hepatic rosettes. The diagnosis autoimmune hepatitis was made according to The Simplified Diagnosis Criteria and The Revised Original Scoring System of the International Autoimmune Hepatitis Group. Her clinical and laboratory were improved after received prednisolone and azathioprine.

Figure 1 พยาธิสภาพของชิ้นเนื้อตับย้อมด้วย hematoxylin และ eosin (H&E)

รูป A และ B: Interface hepatitis (ลูกศรแดง), Cluster of plasma cells infiltration (หัวลูกศรดำ)
รูป C: Hepatic rosette formation (*),Emperipolesis (หัวลูกศรดำ)
Nilai Sosial dan Moralitas dalam Naskah Drama Janji Senja Karya Taofan Nalisaputra
Authors: Nugroho Agung 
Published: January 2019

Tujuan penelitian ini untuk mendeskripsikan nilai sosial dan nilai moral naskah drama. Naskah drama yang digunakan berjudul Janji Senja Karya Taofan Nalisaputra. Penelitian ini menggunakan metode deskriptif kualitatif. Teknik pengumpulan data menggunakan teknik dokumentasi. Teknik analisis data dilakukan dengan cara membaca, pengkodingan, pendeskripsian, interprestasi, dan kesimpulan. Hasil penelitian ini merupakan deskripsi kajian nilai sosial dan nilai moral naskah drama Janji Senja karya Taofan Nalisaputra. Hasil dari kajian nilai sosial yang mendominasi naskah drama Janji Senja karya Taofan Nalisaputra yaitu nilai sosial diri dengan orang lain hal ini terlihat dari kutipan “Istri harus patuh pada suami, ujaran yang kasar berdampak menyakiti hati orang lain, kebencian yang memutuskan tali darah dalam tubuh, lebih mementingkan orang lain dari pada ibunya sendiri”. Hal ini tampak jelas dituangkan oleh pengarang dalam naskahnya. Sedangkan nilai moral naskah drama Janji Senja karya Taofan Nalisaputra melingkupi beberapa aspek di antaranya, berbentuk tingkah laku yang sesuai dengan kesusilaan, budi pekerti, dan juga akhlak. Berdasarkan hasil tersebut terlihat jelas jika naskah drama Janji Senja karya Taofan Nalisaputra sangat kental akan nilai sosial dan moral hal ini karena naskah drama yang diangkat berkaitan langsung dengan kehidupan sehari-hari di masyarakat.