bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trocar scar abdominal wall adenomyoma following laparoscopic hysterectomy: case report
Authors: Prospero Rossella , Carafa Anastasia , Sagrada Paola Francesca , Ahmed Naghia , Scagnelli Paola , Ballabio Michele Maria , Garuti Giancarlo , Soligo Marco 
Published: November 2024

Abstract
Abdominal wall endometriosis (AWE) within the scar of a trocar insertion is seldom reported as a complication of laparoscopy. We describe the case of a 46 year-old woman suffering from uterine leiomyomas who underwent laparoscopic hysterectomy. One year later, she developed a painful abdominal wall mass, beneath the scar of suprapubic port-site trocar insertion. The diagnostic work-up, consisting in ultrasonography, magnetic resonance imaging and needle biopsy led to a diagnosis of AWE. Initially, a progestogen therapy was administered, obtaining relief from pain symptoms but insignificant reduction of lump’ size. Therefore, the patient underwent a laparotomic resection of the mass. Pathologic findings showed endometriotic tissue mixed with smooth muscle cells, leading to the diagnosis of extrauterine adenomyoma. Six months after surgery, neither AWE relapse nor incisional hernia was found. To our knowledge, no case of parasitic adenomyoma development in a trocar scar following a laparoscopy has been described before in literature.
Is climate change ungovernable?
Authors: Edwards Paul N 
Published: November 2024

Abstract
Climate governance spans multiple levels of socio-political organisation, from global institutions to local governments and non-governmental entities. Coordination among them is often weak, chaotic, or non-existent, hindering effective climate action. Massive infrastructure built on fossil energy systems, supported by powerful interests and long-term social commitments, exacerbates the challenge. This article begins with a review of recent climate science and data pointing to potentially catastrophic outcomes within the next few decades. It then explores failures and weaknesses of existing governance modes. Incantatory ungovernance declares broad objectives but lacks specific mechanisms to achieve them. De-governance through policy reversal and enforcement failure has already occurred and will happen again, especially where overlapping jurisdictions conflict. Anti-governance takes multiple forms, including ideology, greenwashing, and denialism. In the face of these common failure modes, the most effective climate ‘policy’ is infrastructural change.
Architecture of TOI-561 planetary system
Authors: Piotto G , Zingales T , Borsato L , Egger J A , Correia A C M , Simon A E , Florén H -G , Sousa S G , Maxted P F L , Nardiello D , Malavolta L , Wilson T G , Alibert Y , Adibekyan V , Bonfanti A , Luque R , Santos N C , Hooton M J , Fossati L , Smith A M S , Salmon S , Lacedelli G , Alonso R , Bárczy T , Barrado Navascues D , Barros S C C , Baumjohann W , Beck T , Benz W , Billot N , Brandeker A , Broeg C , Buder M , Cameron A Collier , Csizmadia Sz , Cubillos P E , Davies M B , Deleuil M , Deline A , Demangeon O D S , Demory B -O , Derekas A , Edwards B , Ehrenreich D , Erikson A , Fortier A , Fridlund M , Gandolfi D , Gazeas K , Gillon M , Güdel M , Günther M N , Heitzmann A , Helling Ch , Isaak K G , Kiss L L , Korth J , Lam K W F , Laskar J , Lecavelier des Etangs A , Lendl M , Leonardi P , Magrin D , Mantovan G , Mordasini C , Nascimbeni V , Olofsson G , Ottensamer R , Pagano I , Pallé E , Peter G , Ottensamer R , Pollacco D , Queloz D , Ragazzoni R , Rando N , Ratti F , Rauer H , Ribas I , Scandariato G , Ségransan D , Sicilia D , Stalport M , Sulis S , Szabó Gy M , Udry S , Ulmer-Moll S , Van Grootel V , Venturini J , Villaver E , Walton N A , Winn J N , Wolf S 
Published: November 2024

ABSTRACT
We present new observations from CHEOPS (CHaracterising ExOPlanet Satellite) and TESS (Transiting Exoplanet Survey Satellite) to clarify the architecture of the planetary system hosted by the old Galactic thick disc star TOI-561. Our global analysis, which also includes previously published photometric and radial velocity data, incontrovertibly proves that TOI-561 is hosting at least four transiting planets with periods of 0.44 d (TOI-561 b), 10.8 d (TOI-561 c), 25.7 d (TOI-561 d), and 77.1 d (TOI-561 e) and a fifth non-transiting candidate, TOI-561f with a period of 433 d. The precise characterization of TOI-561’s orbital architecture is interesting since old and metal-poor thick disc stars are less likely to host ultrashort-period super-Earths like TOI-561 b. The new period of planet -e is consistent with the value obtained using radial velocity alone and is now known to be $77.14399\pm 0.00025$ d, thanks to the new CHEOPS and TESS transits. The new data allowed us to improve its radius ($R_p = 2.517 \pm 0.045\,\mathrm{ R}_{\rm{\oplus }}$ from 5 per cent to 2 per cent precision) and mass ($M_p = 12.4 \pm 1.4\, \mathrm{ M}_{\rm{\oplus }}$) estimates, implying a density of $\rho _p = 0.778 \pm 0.097\, \rho _{\rm{\oplus }}$. Thanks to recent TESS observations and the focused CHEOPS visit of the transit of TOI-561 e, a good candidate for exomoon searches, the planet’s period is finally constrained, allowing us to predict transit times through 2030 with 20-min accuracy. We present an updated version of the internal structure of the four transiting planets. We finally performed a detailed stability analysis, which confirmed the long-term stability of the outer planet TOI-561 f.
Black hole mass estimate in OJ 287 based on the bulk-motion comptonization model
Authors: Kuznetsov Sergey 
Published: November 2024

ABSTRACT
The multiwavelength outburst activity in the BL Lacertae source OJ 287 has sparked a lot of controversy about whether the source contains one or two black holes (BHs) and what characteristics of this BH binary would be. In this article, we present the results of analysis of the X-ray flaring activity of OJ 287 using the data of Swift/XRT observations. We discovered that the energy spectra in all spectral states can be adequately fit with the XSPEC bulk-motion Comptonization (BMC) model. As a result, we found that the X-ray photon index of the BMC model, $\Gamma$ correlates with the mass accretion rate, $\dot{M}$. We found the photon index $\Gamma$ to increase monotonically with accretion rate $\dot{M}$ from $\Gamma \sim 2$ in the intermediate state (IS) to $\Gamma \sim 2.5$ the high/soft state (HSS) with subsequent saturation at $\Gamma \sim$ 2.6 level at higher luminosities. This type of behaviour of the spectral index is remarkably similar to the pattern observed in a number of established stellar-mass BH candidates. Assuming the universality of the observed pattern of the correlation between the photon index and mass accretion rate and using the well-studied stellar-mass binaries GX 339–4 and XTE J1859–226 to calibrate the model, we estimate a BH mass $\sim 2\times 10^8$ solar masses, which likely pertains to the secondary component of the BH binary in OJ 287.
BindingDB in 2024: a FAIR knowledgebase of protein-small molecule binding data
Authors: Liu Tiqing , Hwang Linda , Burley Stephen K , Nitsche Carmen I , Southan Christopher , Walters W Patrick , Gilson Michael K 
Published: November 2024

Abstract
BindingDB (bindingdb.org) is a public, web-accessible database of experimentally measured binding affinities between small molecules and proteins, which supports diverse applications including medicinal chemistry, biochemical pathway annotation, training of artificial intelligence models and computational chemistry methods development. This update reports significant growth and enhancements since our last review in 2016. Of note, the database now contains 2.9 million binding measurements spanning 1.3 million compounds and thousands of protein targets. This growth is largely attributable to our unique focus on curating data from US patents, which has yielded a substantial influx of novel binding data. Recent improvements include a remake of the website following responsive web design principles, enhanced search and filtering capabilities, new data download options and webservices and establishment of a long-term data archive replicated across dispersed sites. We also discuss BindingDB’s positioning relative to related resources, its open data sharing policies, insights gleaned from the dataset and plans for future growth and development.
Determination of urine volume and glomerular filtration rate using d-serine and d-asparagine
Authors: Tanaka Ryo , Sakai Shinsuke , Taniguchi Ayumu , Kawamura Masataka , Higa-Maegawa Yoko , Matsumura Soichi , Fukae Shota , Nakazawa Shigeaki , Kimura-Ohba Shihoko , Horio Masaru , Takahara Shiro , Imamura Ryoichi , Nonomura Norio , Mizui Masayuki , Isaka Yoshitaka , Kakuta Yoichi , Kimura Tomonori 
Published: November 2024

ABSTRACT

Background
Measurement of glomerular filtration rate (GFR) is subject to inaccurate urine collection. Clearances of d-serine and d-asparagine, rare enantiomers of amino acids, are the measures of GFR since they are almost free of tubular secretion and reabsorption. We hypothesize that d-serine and d-asparagine can accurately determine urine volume and GFR.

Methods
This cross-sectional observational study included 209 living kidney transplant donors and recipients for whom GFR was measured using the clearance of inulin. Assuming that urine excretions of d-serine and d-asparagine are constant and using urine levels of d-serine and d-asparagine from each urine collection, an equation for estimated urine volume (eUV) was established. Based on the eUV, the abnormal urine volume was replaced with an estimate with which the GFR was re-evaluated.

Result
Clearances of d-serine and d-asparagine were minor in proportional biases when compared with that of creatinine. Using 627 urine collections, the equation for eUV (mL/min) was established as 21.88/urine d-Ser(0.40 + 0.20 × log10(urine d-Asn)). Using eUV, we identified 20 instances where urine collection volumes varied significantly from the estimated values. After replacement with eUV, measured GFR (mGFR) was corrected to adjusted mGFR, which was within approximately 20 mL/min/1.73 m2 of the mGFR.

Conclusion
d-Serine and d-asparagine are nearly completely excreted in urine after glomerular filtration, enabling the estimation of urine volume and correct mGFR. Besides reflecting GFR, d-serine and d-asparagine can be used to estimate urine volume. By applying the eUV method, mGFR determined using clearance methods becomes more accurate.
LTBK-02. EVALUATION OF PAXALISIB IN GBM AGILE PHASE 3 REGISTRATION PLATFORM TRIAL FOR NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA
Authors: Mellinghoff Ingo K , Cloughesy Timothy , Alexander Brian , Berry Donald A , Buxton Meredith , Cavenee Webster , Colman Howard , de Groot John , Ellingson Benjamin M , Gordon Gary B , Lassman Andrew B , Lim Michael , Khasraw Mustafa , Perry James , Sulman Erik P , Weller Michael , Wen Patrick , Yung W K Alfred , Berry Nicholas , Graves Todd , Detry Michelle , Hyddmark E M Viktoria , Johnsson Adam , Kling Heather , McGlothlin Anna , Powell Ashley , Untch Sarah , Aquilanti Elisa , Blondin Nicholas , Boulmay Brian , de la Fuente Macarena , Drappatz Jan , Jordan Justin , Kaley Thomas J , Lobbous Mina , Mikkelsen Tom , Newton Herbert , Owen Scott , Peters Katherine , Schiff David , Sherman Wendy , Weathers Shiao-Pei , Youssef Michael , Friend John , Lee Eudocia 
Published: November 2024

Abstract

GBM AGILE(NCT03970447) is a phase 2/3 Bayesian adaptive registration platform trial testing multiple therapies against a common control. Paxalisib, a PI3K/mTOR inhibitor, is the 3rd arm in the trial to conclude evaluation.

METHODS
Paxalisib was open to patients with newly diagnosed unmethylated (NDU) and recurrent (RD) glioblastoma, with three possible signatures: NDU, RD, and All(NDU+RD). Arm enrollment occurred Dec2020 through May2022. Control patients were enrolled from study initiation (July2019) and were treated with temozolomide(NDU) or lomustine(RD). GBM AGILE investigational arms have 1 or 2 stages, with adaptive randomization in stage 1 and fixed randomization if arms continue to stage 2. Efficacy is based on OS hazard ratio(HR) of Arm/Control. Efficacy goal is final Bayesian probability ≥ 98% for HR&lt;1.00 in combined Stages. An Arm continues to Stage 2 if Bayesian predictive power (PP) ≥ 0.8. An Arm stops accruing in Stage 1 if it reaches maximal sample size(N) or does not meet a minimum efficacy threshold (PP&lt;0.25 for all signatures when N&gt;50). Clinical cut-off is 12 months after accrual stops. The maximum N for paxalisib was approximately 150(Stage 1) and 50(Stage 2).

RESULTS
After paxalisib reached &gt;150 patients in Stage 1, accrual stopped [Paxalisib/control N 54/75(NDU), 100/188(RD)]. Neither PP thresholds for moving to Stage 2 nor stopping for minimum efficacy were met. Following an unplanned public disclosure that the arm did not continue to stage 2, clinical cut-off for final analysis (planned May2023) was updated to public disclosure date (August2022). At final analysis mean HRs were 0.89(NDU), 1.25(RD), 1.05(All), probabilities of HR&lt;1.00 of 0.72(NDU), 0.076(RD), 0.398(All). Model estimated median OS paxalisib/control (months) were 14.77/13.84(NDU) and 8.58/10.06(RD).

CONCLUSION
Paxalisib did not show survival benefit over cumulative control in final primary analysis; additional secondary analyses are being considered. GBM AGILE continues to rapidly and efficiently assess therapies in ND and RD glioblastoma.
Carpal tunnel syndrome severity and work: a case-control study
Authors: Curti S , Ginanneschi F , Salce C , Argentino A , Mattioli S , Mondelli M 
Published: November 2024

Abstract

Background
Carpal tunnel syndrome (CTS) is a socially relevant condition. Risk factors associated with CTS severity and work have not been explored.

Aims
This case-control study aims to investigate the association between CTS severity and occupational biomechanical overload considering personal anthropometric risk factors.

Methods
We consecutively enrolled one CTS case for two controls. CTS cases were grouped into three classes of progressive clinical and electrophysiological severity according to two validated scales. Job titles were coded according to the International Standard Classification of Occupations (ISCO 88) and grouped into two broad socio-occupational categories: blue-collar and white-collar workers.
The associations between CTS (or CTS severity) and blue-collar status were assessed using unconditional (or multinomial) logistic regression models adjusted for age, gender, centre and two anthropometric indexes: wrist-palm ratio and waist-stature ratio. Odds ratios (OR) or relative risk ratio and 95% confidence intervals (95% CI) were calculated, as appropriate.

Results
We included 183 cases and 445 controls. Blue-collar status was a risk factor for CTS (OR 2.4; 95% CI 1.5–3.8). Among job titles, vine and/or olive tree growers (OR 6.0; 95% CI 2.0–17.9) and food processing workers (OR 4.8; 95% CI 1.5–15.2) were at higher risk. At multinomial logistic regression analysis, blue-collar status and the two anthropometric indexes were associated with moderate/severe CTS, after mutual adjustment.

Conclusions
Blue-collar workers showed a higher risk of CTS than white-collar workers, adjusting for anthropometric and body measures as well. Preventive interventions should be addressed to decrease the biomechanical overload of the upper limbs and limit the overweight.
Pragmatist Instrumentalism as a Paradigm of Intercultural Legal Semiotics
Authors: Langner-Pitschmann Annette 
Published: November 2024

Abstract
The project of intercultural legal semiotics faces the dilemma between the situational character of legal meaning and its cross-situational claim to validity. This article examines the extent to which John Dewey’s conception of cultural naturalism can contribute to further exploration of this inherent conflict. Guided by the assumption that the question of the intercultural comprehensibility of legal meanings refers to the linguistic paradigm of the pragmatic turn, it sets out with a look at Wittgenstein’s later philosophy. Against this backdrop, Dewey’s concepts of inquiry and imagination are discussed, revealing their potential for the project of cross-cultural production of legal meaning. In light of Dewey’s theory of religion, in which the implications of these concepts are condensed, this potential is examined more closely. It becomes apparent that Dewey’s deep trust in the human ability to interpret experience appropriately and meaningfully is a crucial prerequisite for a sustainable perspective on the challenge of an intercultural semiotics of law.
Songs, Diction, Lyrics, IPA, and Translations
Authors: Ulloa Juanita 
Published: November 2024

Abstract
Mexican Spanish is immediately identifiable to Spanish speakers all over the world. Mexico has many regional variants within its thirty-two states as well. Why study Mexican Spanish lyric diction? All, including advanced singers, train constantly to develop a discerning ear for varying pronunciation depending on the region. The northern Mexico corrido will have a slightly different pronunciation, brighter intonation, and resonance than a bolero or huapango, for example. The system of International Phonetic Alphabet (IPA) is introduced with lesson plans and practice sheets using mariachi word examples. IPA appears in every dictionary in parentheses after each word, allowing readers to sound it out. Singers learn to research and study their songs through history studies. Tips on how to memorize lyrics are provided. Twenty songs are presented with song guide sheets with melody and chords, full IPA, and literal and poetic translations.
The Ontology of Attitudinal and Modal Objects
Authors: Moltmann Friederike 
Published: November 2024

Abstract
This chapter elaborates the ontology of attitudinal and modal objects, and more generally the ontology of ‘satisfiable objects’, or ‘satisfiables’, which include intensional objects like debts and searches. It distinguishes different types of attitudinal objects and discusses modal and intensional objects as entities both similar to and distinct from attitudinal objects. It introduces the characteristic properties of satisfiables, properties of concreteness and three content-related properties: having satisfaction conditions, having a part structure based on partial content, and entering similarity relations on the basis of being the same in content. It distinguishes different types of satisfaction conditions that different types of satisfiables come with. It clarifies the ways in which satisfiables differ from corresponding actions (claims vs. acts of claiming, assumptions vs. acts of assuming), distinguishing products from results of acts. It distinguishes state-related attitudinal objects (e.g., beliefs) from the corresponding states (belief states). It critically discusses Twardowski’s distinction between actions and products.
Levels of Linguistic Acts and the Semantics of Saying and Quoting
Authors: Moltmann Friederike 
Published: November 2024

Abstract
This chapter extends the semantics of attitude reports based on attitudinal objects to verbs of saying and quotation. It does so by positing objects that correspond to Austin’s hierarchy of speech acts: phonetic, phatic, locutionary, and locutionary objects. It argues for the semantic importance of the distinction between locutionary and illocutionary objects and shows that that-clause complements of verbs of saying act as predicates of locutionary objects, not illocutionary objects. It argues that pure quotations have primarily the status of predicates, predicated phatic of objects. Direct quotes are analyzed as predicates of illocutionary objects as well as of the phatic objects on which the locutionary objects are based. The chapter gives a semantic analysis of special quantifiers with verbs of saying, including words-NPs (a few words). It outlines a novel compositional semantics of quotation based on a syntactic structure that includes lower-level linguistic structures as input to semantic interpretation.
Conclusions and Avenues for Further Development
Authors: Moltmann Friederike 
Published: November 2024

Abstract
This chapter summarizes the main features of the approach developed in the book. It relates the overall view to Michael Devitt’s motto ‘metaphysics first’ and contrasts it with that of ‘descriptive metaphysics first’. It lists a range of issues that invites further elaboration of both philosophical and linguistic sorts. On the philosophical side, they concern the ontology of attitudinal and modal objects, which displays both features of concreteness and abstractness as well as a particular connection to normativity. On the linguistic side, they concern the need of accounting for the semantics of other types of clausal complements than that-clauses, such as infinitival clauses and interrogative clauses, as well as the need to develop proper syntactic theories within which the analyses can be cast that in the book were formulated within what has been called ‘simplified syntax’ .
The Temple of Ramses II at Abu Simbel
Authors: Holliday Peter J. 
Published: November 2024

Abstract
Chapter 2 examines how Egyptian political history begins with its art history in the Palette of Narmer. Hieroglyphic inscriptions distinguish the portrayal of persons and events. Innovations to Egyptian artistic conventions facilitated the commemorative function of relief programs during the New Kingdom, as demonstrated by the decoration of the temple of Ramses II at Abu Simbel, which celebrates the putative Egyptian victory over the Hittites at Battle of Kadesh. Descriptive details rather than hierarchical proportions, landscape features, and varied orientation of the figures contrast with typical Egyptian compositions to lend the imagery specificity and realism while maintaining their rhetorical, propagandistic function. Passages from the Poem of Pentaur are placed within the continuous narrative to render a moving account of the battle.
The Bayeux Embroidery
Authors: Holliday Peter J. 
Published: November 2024

Abstract
Chapter 5 examines the controversies surrounding the Bayeux Embroidery, commissioned to commemorate Duke William’s eleventh-century conquest of England. These include the reliability of its sequential narrative, which betrays Norman and English biases; who was responsible for commissioning it (suggested patrons range from English or Norman queens to English and Norman clerics); and who made it. This chapter examines the evidence for where it was designed, either England or France, and where it was crafted. It considers how scholars have viewed the detail of its visual narrative as a primary source rivalling written accounts in reliability, and how its mixed messages may have been designed to forge a new national identity incorporating both the English and Norman peoples. The changing fortunes of its reception are introduced as further material for modern interpretation.
Nonlinear Dispersive Wave Equations
Authors: Carretero-González R. , Frantzeskakis D.J. , Kevrekidis P.G. 
Published: November 2024

Abstract
In this chapter, we introduce several nonlinear dispersive wave models, which appear generically in a wide range of contexts and applications in physics, engineering, biosciences, and so on. Many of these models will be analyzed in more detail in the next chapters. Our approach is typically characterized by two steps. First, we will construct the linear (or "the linearized") part of the various models via simple (chiefly of polynomial type) dispersion relations. Second, we introduce nonlinearity, via a heuristic approach, relying on the fundamental effect of the phase-velocity dependence on the field-amplitude (this dependence discriminates, in fact, linear and nonlinear waves). The final twist will be the combination of dispersion and nonlinearity, which, as we will see, will lead to a variety of nonlinear dispersive wave equations. The suggested methodology is quite useful in that it provides an intuitive understanding of the structure of these important models.