bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sacrificial-template-free synthesis of core-shell C@Bi2S3 heterostructures for efficient supercapacitor and H2 production applications
Authors: Vattikuti S. V. Prabhakar , Police Anil Kumar Reddy , Shim Jaesool , Byon Chan 
Published: March 2018

AbstractCore-shell heterostructures have attracted considerable attention owing to their unique properties and broad range of applications in lithium ion batteries, supercapacitors, and catalysis. Conversely, the effective synthesis of Bi2S3 nanorod core@ amorphous carbon shell heterostructure remains an important challenge. In this study, C@Bi2S3 core-shell heterostructures with enhanced supercapacitor performance were synthesized via sacrificial- template-free one-pot-synthesis method. The highest specific capacities of the C@Bi2S3 core shell was 333.43 F g−1 at a current density of 1 A g−1. Core-shell-structured C@Bi2S3 exhibits 1.86 times higher photocatalytic H2 production than the pristine Bi2S3 under simulated solar light irradiation. This core-shell feature of C@Bi2S3 provides efficient charge separation and transfer owing to the formed heterojunction and a short radial transfer path, thus efficiently diminishing the charge recombination; it also facilitates plenty of active sites for the hydrogen evolution reaction owing to its mesoporous nature. These outcomes will open opportunities for developing low-cost and noble-metal-free efficient electrode materials for water splitting and supercapacitor applications.
Surgical Anatomy of the Superior Mesenteric Vessels Related to Colon and Pancreatic Surgery: A Systematic Review and Meta-Analysis
Authors: Negoi Ionut , Beuran Mircea , Hostiuc Sorin , Negoi Ruxandra Irina , Inoue Yosuke 
Published: March 2018

AbstractThe surgeon dissecting the base of the mesenterium, around the superior mesenteric vein (SMV) and artery, is facing a complex tridimensional vascular anatomy and should be aware of the anatomical variants in this area. The aim of this systematic review is to propose a standardized terminology of the superior mesenteric vessels, with impact in colon and pancreatic resections. We conducted a systematic search in PubMed/MEDLINE and Google Scholar databases up to March 2017. Forty-five studies, involving a total of 6090 specimens were included in the present meta-analysis. The pooled prevalence of the ileocolic, right colic and middle colic arteries was 99.8%, 60.1%, and 94.6%, respectively. The superior right colic vein and Henle trunk were present in 73.9%, and 89.7% of specimens, respectively. In conclusion, the infra-pancreatic anatomy of the superior mesenteric vessels is widely variable. We propose the term Henle trunk to be used for any venous confluence between gastric, pancreatic and colic veins, which drains between the inferior border of the pancreas and up to 20 mm downward on the right-anterior aspect of the SMV. The term gastrocolic trunk should not be synonymous, but a subgroup of the Henle trunk, together with to gastropancreatocolic, gastropancreatic, or colopancreatic trunk.
Dna is a New Target of Parp3
Authors: Belousova E. A. , Ishchenko А. A. , Lavrik O. I. 
Published: March 2018

AbstractMost members of the poly(ADP-ribose)polymerase family, PARP family, have a catalytic activity that involves the transfer of ADP-ribose from a beta-NAD+-molecule to protein acceptors. It was recently discovered by Talhaoui et al. that DNA-dependent PARP1 and PARP2 can also modify DNA. Here, we demonstrate that DNA-dependent PARP3 can modify DNA and form a specific primed structure for further use by the repair proteins. We demonstrated that gapped DNA that was ADP-ribosylated by PARP3 could be ligated to double-stranded DNA by DNA ligases. Moreover, this ADP-ribosylated DNA could serve as a primed DNA substrate for PAR chain elongation by the purified proteins PARP1 and PARP2 as well as by cell-free extracts. We suggest that this ADP-ribose modification can be involved in cellular pathways that are important for cell survival in the process of double-strand break formation.
Rapid and transient oxygen consumption increase following acute HDAC/KDAC inhibition in Drosophila tissue
Authors: Becker Lore , Nogueira Melanie Schmitt , Klima Caroline , de Angelis Martin Hrabe , Peleg Shahaf 
Published: March 2018

AbstractEpigenetic deregulation, such as the reduction of histone acetylation levels, is thought to be causally linked to various maladies associated with aging. Consequently, histone deacetylase inhibitors are suggested to serve as epigenetic therapy by increasing histone acetylation. However, previous work suggests that many non-histone proteins, including metabolic enzymes, are also acetylated and that post transitional modifications may impact their activity. Furthermore, deacetylase inhibitors were recently shown to impact the acetylation of a variety of proteins. By utilizing a novel technique to measure oxygen consumption rate from whole living tissue, we demonstrate that treatment of whole living fly heads by the HDAC/KDAC inhibitors sodium butyrate and Trichostatin A, induces a rapid and transient increase of oxygen consumption rate. In addition, our study indicates that the rate increase is markedly attenuated in midlife fly head tissue. Overall, our data suggest that HDAC/KDAC inhibitors may induce enhanced mitochondrial activity in a rapid manner. This observed metabolic boost provides further, but novel evidence, that treating various maladies with deacetylase inhibitors may be beneficial.
LOFAR observations of the quiet solar corona
Authors: Vocks C. , Mann G. , Breitling F. , Bisi M. M. , Dąbrowski B. , Fallows R. , Gallagher P. T. , Krankowski A. , Magdalenić J. , Marqué C. , Morosan D. , Rucker H. 
Published: March 2018

Context. The quiet solar corona emits meter-wave thermal bremsstrahlung. Coronal radio emission can only propagate above that radius, Rω, where the local plasma frequency equals the observing frequency. The radio interferometer LOw Frequency ARray (LOFAR) observes in its low band (10–90 MHz) solar radio emission originating from the middle and upper corona.
Aims. We present the first solar aperture synthesis imaging observations in the low band of LOFAR in 12 frequencies each separated by 5 MHz. From each of these radio maps we infer Rω, and a scale height temperature, T. These results can be combined into coronal density and temperature profiles.
Methods. We derived radial intensity profiles from the radio images. We focus on polar directions with simpler, radial magnetic field structure. Intensity profiles were modeled by ray-tracing simulations, following wave paths through the refractive solar corona, and including free-free emission and absorption. We fitted model profiles to observations with Rω and T as fitting parameters.
Results. In the low corona, Rω < 1.5 solar radii, we find high scale height temperatures up to 2.2 × 106 K, much more than the brightness temperatures usually found there. But if all Rω values are combined into a density profile, this profile can be fitted by a hydrostatic model with the same temperature, thereby confirming this with two independent methods. The density profile deviates from the hydrostatic model above 1.5 solar radii, indicating the transition into the solar wind.
Conclusions. These results demonstrate what information can be gleaned from solar low-frequency radio images. The scale height temperatures we find are not only higher than brightness temperatures, but also than temperatures derived from coronograph or extreme ultraviolet (EUV) data. Future observations will provide continuous frequency coverage. This continuous coverage eliminates the need for local hydrostatic density models in the data analysis and enables the analysis of more complex coronal structures such as those with closed magnetic fields.
Ergot Alkaloids and their Hallucinogenic Potential in Morning Glories
Authors: Steiner Ulrike , Leistner Eckhard 
Published: March 2018

AbstractNaturally occurring and semisynthetic ergot alkaloids play a role in health care or as recreational drugs in Western and indigenous Mexican societies. Evidence is summarized that ergot alkaloids present in Central American Convolvulaceae like Turbina corymbosa, Ipomoea violacea, and Ipomoea asarifolia are colonized by different species of a newly described clavicipitaceous fungal genus named Periglandula. The fungi are associated with peltate glandular trichomes on the adaxial leaf surface of its host plants. The Periglandula fungi are not yet culturable in vitro but were demonstrated to have the capacity to synthesize ergot alkaloids. The alkaloids do not remain in the fungal mycelium but are translocated via the glandular trichomes into their plant host. Both fungi and host benefit from a symbiotic lifestyle. In evolutionary terms the alkaloid biosynthetic gene cluster in the Periglandula/Ipomoea symbiosis is likely to have a conserved (basic) structure while biosynthetic ergot gene clusters within the genera Claviceps and Epichloe were under ecological selection for alkaloid diversification.
AMNOG – Bessere Arzneimittel kosten auch mehr
Authors: Potempa Christoph 
Published: March 2018

Lauenroth VD et al. Pharmaceutical Pricing in Germany: How is Value Determined within the Scope of AMNOG. Value
Health 2017; 20: 927–935
Vor dem Hintergrund des AMNOG haben die Autoren um Lauenroth et al. empirisch untersucht, ob sich die
Preisbildung neuer Arzneimittel tatsächlich an der Bewertung des Zusatznutzens durch den G-BA orientiert.
Die Autoren konnten zeigen, dass diese Zielsetzung des AMNOG bisher weitgehend erreicht werden
konnte.
Decision-making processes in direct and inverse translation through retrospective protocols
Authors: Ferreira Aline , Gottardo Alexandra , Schwieter John W. 
Published: March 2018

AbstractMetacognitive aspects of decision-making processes were investigated in eight professional translators who translated related and unrelated texts from L2 English into L1 Portuguese and also from L1 into L2. Retrospective protocols were recorded after each translation task. Verbal utterances were classified into two categories (problem identification and prospective solution) and each one was divided into several subcategories. The data analyses evaluated metacognitive activities during decision-making processes. Results suggest that noteworthy differences between direct and inverse translation can be assessed via retrospective protocols and that translator performance and behavior might be closely related to the source text.
Understanding the social and economic aspects of upland rice farming
Authors: Taridala S A A , Abdullah W G , Suaib  , Wahyuni S , Wianti N I , Zani M , Jabuddin L O , Yusria W O , Limi M A , Ekaputri A S 
Published: March 2018

Abstract
The objectives of this study were to (1) analyze the socio-economic characteristics of upland rice farmers, and (2) to analyze the productivity of farming in South Konawe Regency of Southeast Sulawesi Province, Indonesia. The analysis used in this research was combine economic research through quantitative and qualitative analysis. This research was conducted by survey method. The results showed that (1) farmers are generally in productive age, dominated by men, with low formal education level, and moderate family members, (2) upland rice farming is cultivated in medium land area, with fixed costs higher than variable cost, productivity that has been increased but still lower than rice paddy, and the price of rice production is relatively higher than rice paddy production price, and (3) feasible to cultivate dryland rice, and has a high efficiency value.
A rare missense mutation in MYH6 associates with non-syndromic coarctation of the aorta
Authors: Bjornsson Thorsteinn , Thorolfsdottir Rosa B , Sveinbjornsson Gardar , Sulem Patrick , Norddahl Gudmundur L , Helgadottir Anna , Gretarsdottir Solveig , Magnusdottir Audur , Danielsen Ragnar , Sigurdsson Emil L , Adalsteinsdottir Berglind , Gunnarsson Sverrir I , Jonsdottir Ingileif , Arnar David O , Helgason Hrodmar , Gudbjartsson Tomas , Gudbjartsson Daniel F , Thorsteinsdottir Unnur , Holm Hilma , Stefansson Kari 
Published: March 2018

Abstract

Aims
Coarctation of the aorta (CoA) accounts for 4–8% of congenital heart defects (CHDs) and confers substantial morbidity despite treatment. It is increasingly recognized as a highly heritable condition. The aim of the study was to search for sequence variants that affect the risk of CoA.

Methods and results
We performed a genome-wide association study of CoA among Icelanders (120 cases and 355 166 controls) based on imputed variants identified through whole-genome sequencing. We found association with a rare (frequency = 0.34%) missense mutation p.Arg721Trp in MYH6 (odds ratio = 44.2, P = 5.0 × 10−22), encoding the alpha-heavy chain subunit of cardiac myosin, an essential sarcomere protein. Approximately 20% of individuals with CoA in Iceland carry this mutation. We show that p.Arg721Trp also associates with other CHDs, in particular bicuspid aortic valve. We have previously reported broad effects of p.Arg721Trp on cardiac electrical function and strong association with sick sinus syndrome and atrial fibrillation.

Conclusion
Through a population approach, we found that a rare missense mutation p.Arg721Trp in the sarcomere gene MYH6 has a strong effect on the risk of CoA and explains a substantial fraction of the Icelanders with CoA. This is the first mutation associated with non-familial or sporadic form of CoA at a population level. The p.Arg721Trp in MYH6 causes a cardiac syndrome with highly variable expressivity and emphasizes the importance of sarcomere integrity for cardiac development and function.
The Effectiveness of Mindfulness- and Acceptance-Based Interventions for Informal Caregivers of People With Dementia: A Meta-Analysis
Authors: Collins Rebecca N , Kishita Naoko 
Published: March 2018

AbstractBackground and ObjectivesThe application of mindfulness- and acceptance-based interventions (MABIs) for informal caregivers of people with dementia (PwD) is relatively novel, and the current state of the evidence base is unclear. This meta-analysis examined the effectiveness of MABIs on reducing symptoms of depression and burden in informal caregivers of PwD. The quality of included studies was evaluated and moderator variables explored.Research Design and MethodsA literature search of six electronic databases (PsycARTICLES, PsycINFO, MEDLINE Complete, SCOPUS, Web of Science, and ProQuest) was conducted from the first available date to 20 December 2016. Inclusion criteria involved studies that quantitatively investigated the impact of MABIs on depression and/or burden in informal caregivers of PwD.ResultsTwelve studies, providing data on 321 caregivers, were included. Most used mindfulness-based stress reduction and were conducted in the United States. The average attrition among participants was 15.83%. The pre–post effect of MABIs was large for depression and moderate for burden. These effects were largely maintained at follow-up. Significant heterogeneity of effect sizes was observed, with no significant moderators identified. Study quality varied from very poor to moderately good.Discussion and ImplicationsThe low attrition and moderate to large effects suggest that MABIs are acceptable and beneficial for informal caregivers of PwD. The lack of significant moderators could advocate services using more cost-effective forms of MABIs. Further higher-quality research is needed to improve the robustness of the evidence base and enable a meta-analysis to thoroughly examine and quantify moderator variables.
Striking Racial/Ethnic Disparities in Liver Cancer Incidence Rates and Temporal Trends in California, 1988–2012
Authors: Pham Christopher , Fong Tse-Ling , Zhang Juanjuan , Liu Lihua 
Published: March 2018

AbstractBackgroundHepatocellular carcinoma (HCC) is characterized by disparate risk patterns by race/ethnicity. We examined HCC incidence patterns and temporal trends among detailed racial/ethnic populations, including disaggregated Asian-American subgroups.MethodsUsing data from the population-based California Cancer Registry, we identified 41 929 invasive HCC cases diagnosed during 1988–2012. Patients were grouped into mutually exclusive racial/ethnic groups of non-Hispanic (NH) white, NH black, Hispanic, and NH Asian/Pacific Islander (API), as well as Asian subgroups of Chinese, Filipino, Japanese, Korean, Vietnamese, Cambodian, Laotian, and South Asian. Age-adjusted and age-specific incidence rates by sex, race/ethnicity, and time period were calculated. The average annual percent change (AAPC) in incidence rates was estimated using joinpoint regression. All estimates were provided with the 95% confidence intervals (CIs).ResultsAggregated NH API had higher HCC risk than NH whites, NH blacks, and Hispanics. When disaggregated, Southeast Asians (Vietnamese, Cambodians, and Laotians) had overall HCC incidence rates eight to nine times higher than NH whites and more than twice that of other ethnic Asians. Statistically significant rising temporal trends of HCC were found in NH whites, NH blacks, and Hispanics, especially those older than age 50 years. Overall HCC risk declined in Chinese males (AAPC = –1.3%, 95% CI = –2.0 to –0.6), but rose in Filipino (AAPC = +1.2%, 95% CI = 0.3 to 2.1) and Japanese males (AAPC = +3.0%, 95% CI = 0.4 to 5.6) and Vietnamese (AAPC = +4.5%, 95% CI = 0.7 to 8.5) and Laotian (+3.4%, 95% CI = 0.1 to 6.8) females.ConclusionsOur findings provide valuable information for the identification of at-risk ethnic subgroups of Asian Americans while underscoring the importance of disaggregating ethnic populations in cancer research.
Durability of Efavirenz Compared With Boosted Protease Inhibitor-Based Regimens in Antiretroviral-Naïve Patients in the Caribbean and Central and South America
Authors: Caro-Vega Yanink , Belaunzarán-Zamudio Pablo F , Crabtree-Ramírez Brenda E , Shepherd Bryan E , Grinsztejn Beatriz , Wolff Marcelo , Pape Jean W , Padgett Denis , Gotuzzo Eduardo , McGowan Catherine C , Sierra-Madero Juan G 
Published: March 2018

Abstract

Background
Efavirenz (EFV) and boosted protease inhibitors (bPIs) are still the preferred options for firstline antiretroviral regimens (firstline ART) in Latin America and have comparable short-term efficacy. We assessed the long-term durability and outcomes of patients receiving EFV or bPIs as firstline ART in the Caribbean, Central and South America network for HIV epidemiology (CCASAnet).

Methods
We included ART-naïve, HIV-positive adults on EFV or bPIs as firstline ART in CCASAnet between 2000 and 2016. We investigated the time from starting until ending firstline ART according to changes of third component for any reason, including toxicity and treatment failure, death, and/or loss to follow-up. Use of a third-line regimen was a secondary outcome. Kaplan-Meier estimators of composite end points were generated. Crude cumulative incidence of events and adjusted hazard ratios (aHRs) were estimated accounting for competing risk events.

Results
We included 14 519 patients: 12 898 (89%) started EFV and 1621 (11%) bPIs. The adjusted median years on firstline ART were 4.6 (95% confidence interval [CI], 4.4–4.7) on EFV and 3.8 (95% CI, 3.8–4.0) on bPI (P &lt; .001). Cumulative incidence of firstline ART ending at 10 years of follow-up was 32% (95% CI, 31–33) on EFV and 44% (95% CI, 39–48) on bPI (aHR, 0.88; 95% CI, 0.78–0.97). The cumulative incidence rates of third-line initiation in the bPI-based group were 6% (95% CI, 2.4–9.6) and 2% (95% CI, 1.4–2.2) among the EFV-based group (P &lt; .01).

Conclusions
Durability of firstline ART was longer with EFV than with bPIs. EFV-based regimens may continue to be the preferred firstline regimen for our region in the near future due to their high efficacy, relatively low toxicity (especially at lower doses), existence of generic formulations, and affordability for national programs.
‘Not for us the Weekly dose of Sulphur and Brimstone!’ Women, Family and Homoeopathic Medicine in Early Twentieth-century Britain
Authors: Draper Melvyn Lloyd 
Published: March 2018

Summary
During the first three decades of the twentieth century Victorian notions of differentiated gender roles continued to inhibit British women intending on a medical career. For some aspiring women doctors, however, homoeopathic medicine offered way into into the profession, a route that allowed them to sidestep the constraints imposed by masculine medical culture. The appeal of homoeopathy for these women doctors lay partly in its ‘soft healing’ approach and also in its sectarian nature. Extensive intra- and inter-generational affiliative networks provided homoeopathic group cohesion, while its gentle therapeutics contrasted with the powerful pharmaceutical basis of orthodox scientific medicine. For these reasons women homoeopathic doctors embraced the gendered role of woman as caregiver and, turning this to their advantage, were able to forge successful careers in modern British medicine.
Inhalational versus Intravenous Induction of Anesthesia in Children with a High Risk of Perioperative Respiratory Adverse Events
Authors: Ramgolam Anoop , Hall Graham L. , Zhang Guicheng , Hegarty Mary , von Ungern-Sternberg Britta S. 
Published: March 2018

Abstract

Background
Limited evidence suggests that children have a lower incidence of perioperative respiratory adverse events when intravenous propofol is used compared with inhalational sevoflurane for the anesthesia induction. Limiting these events can improve recovery time as well as decreasing surgery waitlists and healthcare costs. This single center open-label randomized controlled trial assessed the impact of the anesthesia induction technique on the occurrence of perioperative respiratory adverse events in children at high risk of those events.

Methods
Children (N = 300; 0 to 8 yr) with at least two clinically relevant risk factors for perioperative respiratory adverse events and deemed suitable for either technique of anesthesia induction were recruited and randomized to either intravenous propofol or inhalational sevoflurane. The primary outcome was the difference in the rate of occurrence of perioperative respiratory adverse events between children receiving intravenous induction and those receiving inhalation induction of anesthesia.

Results
Children receiving intravenous propofol were significantly less likely to experience perioperative respiratory adverse events compared with those who received inhalational sevoflurane after adjusting for age, sex, American Society of Anesthesiologists physical status and weight (perioperative respiratory adverse event: 39/149 [26%] vs. 64/149 [43%], relative risk [RR]: 1.7, 95% CI: 1.2 to 2.3, P = 0.002, respiratory adverse events at induction: 16/149 [11%] vs. 47/149 [32%], RR: 3.06, 95% CI: 1.8 to 5.2, P < 0.001).

Conclusions
Where clinically appropriate, anesthesiologists should consider using an intravenous propofol induction technique in children who are at high risk of experiencing perioperative respiratory adverse events.