bluuebunny/crossref_metadata_2025_split huggingface dataset:
« Nous voulons Dieu » : la manifestation catholique nantaise du 1er mars 1925
Authors: Gourhand Yvon , Routhiau Henri 
Published: October 2024

Le 1er mars 1925, 80 000 hommes se rassemblent à Nantes (Loire-Inférieure) à l’appel de leur évêque, Eugène Le Fer de la Motte, un prélat de combat. Cette manifestation de masse sans précédent est exemplaire d’une mobilisation catholique visant à protester contre les projets laïques du Cartel des gauches (1924-1926), réunissant radicaux et socialistes. Ce réveil des catholiques va concerner notamment l’Ouest et en particulier le territoire de la Vendée militaire. Celui-ci, limitrophe de la capitale des ducs, correspond à la zone insurgée en 1793, une « région-mémoire ». La période voit l’invention de la manifestation catholique de masse orchestrée par la Fédération nationale catholique (FNC) du général de Castelnau, soutenue activement par la hiérarchie catholique française. Durant la période du Cartel, les catholiques tiennent le devant de la scène en investissant en nombre l’espace urbain provincial comme leurs lieux de mémoire. Ces événements sont l’objet d’une quasi-amnésie, y compris de la part des catholiques français, mais ils signifient que l’occupation de la rue par ceux-ci n’a pas débuté en 1984 et encore moins en 2012-2013 ni en 2019, contrairement à ce qui a pu être dit et écrit.
The MicroRNA miR-223 Constrains Colitis-associated Tumorigenesis by Limiting Myeloid Cell Infiltration and Chemokine Expression
Authors: Flynn Ciara L , Markey Gary E , Neudecker Viola , Farrelly Charlotte , Furuta Glenn T , Eltzschig Holger K , Masterson Joanne C , McNamee Eóin N 
Published: November 2024

Abstract
Aberrant intestinal inflammation plays a critical role in the development of colitis-associated colorectal cancer (CAC), yet the mechanisms controlling tumor development by the myeloid immune compartment are not fully understood. Although altered microRNA expression is observed in CAC, it is also unclear how myeloid-specific microRNAs impact the inflammatory process that underpins the continuum from ulcerative colitis to tumorigenesis. In this study, we report that miR-223 acts to limit myeloid-driven inflammation in the azoxymethane (AOM)–dextran sodium sulfate (DSS) model of CAC in mice. In this model, miR-223–/y mice present with significantly larger tumors with an enhanced proliferative signature. Immunoprofiling showed that miR-223–/y mice have significantly increased colonic myeloid immune infiltrate (neutrophils, monocytes, and macrophages) following AOM-DSS. This was accompanied by an increased inflammatory chemokine and cytokine signature for monocytes and neutrophils. Bone marrow chimera studies demonstrate that myeloid-expressed miR-223 is responsible for the enhanced tumor proliferation and inflammatory response. RNA sequencing identified several pathways that could be contributing to the development of CAC in miR-223–/y mice, including the IL-6/IL-17a cytokine family and STAT3 signaling. Lastly, neutrophil depletion with an anti-GR1 Ab (Ly6G/Ly6C) during the initial phase of the AOM-DSS model reduced the tumor burden in miR-223–/y mice. Collectively, our data indicate that miR-223 is an important regulator of mucosal inflammation and acts to constrain the progression from ulcerative colitis to CAC by limiting myeloid-associated inflammation.
Nrf2 Regulates Inflammation by Modulating Dendritic Cell–T Cell Crosstalk during Viral–Bacterial Superinfection
Authors: Duray Alexis M , Miller Leigh M , Dresden Brooke P , Rago Flavia , Antos Danielle , McHugh Kevin J , Alcorn John F 
Published: November 2024

Abstract
Every year millions of people are infected with influenza, which can be complicated by secondary bacterial pneumonia. One factor that may contribute to increased susceptibility to secondary bacterial infection is the modulation of inflammatory cytokines. NF erythroid 2–related factor 2 (Nrf2) has been shown to be a master regulator of the antioxidant response and various inflammatory cytokines. To test the role of Nrf2 during viral–bacterial superinfection, we used a mouse model of influenza–Staphylococcus aureus superinfection with wild-type (WT) or Nrf2-deficient (Nrf2−/−) mice. Loss of Nrf2 reduced influenza burden and increased S. aureus burden during superinfection. Additionally, Nrf2−/− mice had increased abundance of conventional type 1 dendritic cells (DCs). We then tested the interaction between DCs and T cells using an in vitro model of bone marrow–derived DCs with OVA and OT-II T cells. In this system, Nrf2−/− DCs promoted a Th2/regulatory T cell response as opposed to a Th1/Th17 response by WT DCs. This was recapitulated in vivo with superinfected Nrf2−/− mice having increased regulatory T cell populations. We also observed an increased median survival time of Nrf2−/− superinfected mice, due at least in part to increased IL-10 signaling, as anti–IL-10R Ab treatment reduced median survival time to levels seen in WT mice. Overall, these data suggest that loss of Nrf2 promotes differential T cell skewing mediated by DCs that promote a regulatory phenotype, increasing superinfection survival time, despite increased bacterial burden.
Nurse managers on healthy environments for adolescents living with intellectual disabilities
Authors: Malapela Rakgadi G. 
Published: November 2024

Background: Providing care for adolescents living with intellectual disabilities (ALWIDs) within healthcare settings is a complex challenge. These adolescents require an environment that is specialised and conducive to their health, alongside tailored care, treatment and rehabilitation services. Nurse managers play a crucial role in supporting these adolescents, particularly given the difficulties parents face in meeting their unique needs.Objectives: This study aims to explore nurse managers’ perspectives on the creation of a healthy environment for ALWIDs in health facilities.Method: An explorative qualitative study design was conducted. A purposive sampling method was used to select 13 nurse managers from three institutions relevant to the study’s interests. Nurse managers with over 2 years of direct experience in the care, treatment and rehabilitation of ALWIDs were eligible to participate in the study. Selecting these nurse managers ensured the study captured their firsthand experiences and expertise in managing nursing services. Data were collected through face-to-face and telephonic semi-structured interviews, recorded digitally. Braun and Clarke’s six-step thematic analysis was used for data analysis.Results: A safe environment; multi-disciplinary team involvement; competent and adequate staff and a conducive physical environment for structural support are beneficial for ALWIDs.Conclusion: To promote the well-being of ALWIDs, it is essential to establish a spacious and safe environment equipped with sufficient material and non-material resources. Engaging a multi-disciplinary team is vital for addressing their diverse needs.Contribution: This study provided information on what constitutes a healthy environment for ALWIDs to inform clinical practice, nursing education, policy makers and research.
Assessing the Effectiveness of Student-generated Scenario-based Questions as a Tool for Active Learning
Authors: Dhar Dipak Kumar , Saiyad Shaista , Mahajan Neeraj 
Published: October 2024

Background:
Active learning is not new as an educational philosophy and its benefits over passive learning modes are well known. In a competency-based framework, active learning is one of the key thrust areas. However, across the globe studies have shown that its implementation is wrought with challenges and limitations. The present study explored the implementation and effectiveness of an innovative technique of active learning where students in small groups of 5–6 construct structured scenario-based questions (SBQs) and learn in the process of making questions.

Objectives:
The study was done with the objective of assessing the effectiveness and feedback of student-generated SBQs as a method of active learning among medical students.

Materials and Methods:
Sensitization about the project was done followed by deciding the topics which could be covered with this method. The method was implemented in Physiology for Phase 1 MBBS students. During implementation, two small groups (25 students each) were randomly assigned into a “study group” and two into a “control group.” The students were given trigger topics, learning resources and then asked to make SBQs in sub-groups of 5–6. The questions were then opened to discussion, comments and answering by the peers. Knowledge obtained was compared by a pre-post analysis within-group using paired t-test. Between-group analysis was done using independent sample t-test. Feedback was collected both from faculty and students on a Likert Scale.

Results:
The study group recorded a statistically significant higher score (11.92 ± 2.2) after the activity as compared to control group (8.04 ± 2.24). Feedback received from participants and faculty was positive with a mean score of more than 4 on a 5-point Likert Scale for all items, except feasibility in which the faculty feedback score was 3.67. Out of 49 participating students, 31 students commented on qualitative feedback that it was engaging. More than half (26) students mentioned they “want more such sessions.”

Conclusion:
The present study showed that this activity can be implemented in small group teaching hours of the timetable. It retains the benefits of active learning both in terms of learning outcomes and experientially. It can also be used as a means to implement problem-based learning and early clinical exposure.
E-portfolio in Learning and Assessment of Community Medicine for Medical Undergraduate Students
Authors: Mathur Medha , Samuel Sangeetha , Mathur Navgeet , Kaur Manjinder , Badyal Dinesh K. 
Published: October 2024

Background:
A portfolio is a specific collection of student work and achievements in various areas. E-portfolio is an electronic collection that serves the purpose of storage and showcase with the ease of access for both students and evaluators. The knowledge and skills regarding immunization in medical students are of utmost importance for the successful implementation and conduction of the Universal Immunization Program in the country. Hence, this study proposed to use e-portfolio for learning and assessment of immunization in medical undergraduates.

Aim and Objectives:
The aims of this study were as follows: to develop an e-portfolio for learning and assessment in community medicine, to improve the knowledge of immunization schedules of undergraduates using e-portfolio, to improve the vaccination and counseling skills of undergraduates using e-portfolio, and to obtain feedback regarding the e-portfolio from students and faculty.

Methodology:
This interventional educational study was conducted at a tertiary care medical college including 48 students of Phase III MBBS after informed consent was signed. Prevalidated questionnaire and checklist were used for data collection. Students wrote reflections and uploaded their videos of immunization skills and counseling on the e-portfolio and 5 faculty members assessed the students and provided feedback to students. Feedback on the e-portfolio was taken at the end, and descriptive and qualitative analysis was done. Ethical approval for the study was obtained from the institutional ethics committee.

Results:
The e-portfolio was found to be effective in showcasing the progress and learning of the students. E-portfolio improved knowledge, skills, self-directed learning, and reflective writing. The competency of immunization improved after the use of e-portfolio (P < 0.001). Faculty and students had high satisfaction with the e-portfolio and found the e-portfolio to be innovative, convenient to use, and easily accessible.

Conclusions:
E-portfolio is user-friendly and effective in imparting and assessing immunization competency. The use of this intervention for other topics is recommended.
A rare case of isolated congenital anterior urethrocutaneous fistula misinterpreted as urethral duplication
Authors: Sharma Girraj P. , Shekar Ashwin P. , Moirangthem Thoiba 
Published: October 2024

ABSTRACT
While most of the causes of urethrocutaneous fistulae are complications caused by hypospadias repair surgery, congenital anterior urethrocutaneous fistula (CAUF), in the isolated form, is an extremely rare anomaly that had been reported only a few times in literature. In this study, we report the case of 3-year-old uncircumcised boy, who presented with the condition of passing urine through an opening located on the ventral side of his penis since birth. On local examination, a clearly apparent fistula measuring 4 × 3 mm was observed on the ventral side of the shaft of the penis. Distal to that fistula, the glans was intact with a normal wide urethral meatus at its tip, and the prepuce was intact. Voiding cystourethrogram findings were suggestive of a partial duplication of the urethra. On examination under anesthesia, a urethroscopy revealed isolated congenital anterior penile urethrocutaneous fistula. For treatment of this condition, he underwent a single-stage closure of the fistula in layers with the tunica vaginalis as a waterproofing layer. Postoperatively, the catheter was removed on day 10, and he voided well with no fistula. In addition to awareness about the condition, a careful clinical examination, evaluation, and an appropriate surgical technique are required to achieve an optimal functional and esthetic outcome.
Synthesis and Characterization of Nanosilica-Coated Antibiotics, TAP: A Comprehensive Study Utilizing XRD, EDS, FTIR, SEM, and TEM – Invitro Study
Authors: Hameed Mahaboob S. , Antony S. Delphine P. , Shanmugam Rajeshkumar , Raghu Sandhya 
Published: October 2024

Abstract

Aim:
To synthesize nanosilica and investigate its properties, focusing on its interaction with antibiotics, particularly triple antibiotic paste (TAP). Various analytical techniques, including X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM), were employed.

Materials and Methods:
The synthesis of nanosilica involved the meticulous combination of ammonia, ethanol, water, and tetraethyl orthosilicate in a sterile conical flask, followed by centrifugation and drying. Nanosilica was further explored by being combined with antibiotics, including doxycycline, Flagyl, and ciprofloxacin, to create novel antibiotic-coated variants. These combinations were subjected to various analytical techniques to assess their properties.

Results:
The FTIR spectra of silica nanoparticles revealed specific peaks associated with silicon-oxygen bonds and siloxane structures. Nanosilica coated with antibiotics exhibited distinctive peaks indicating the presence of organic components and Si-O-Si bonds, offering insights into their potential applications in drug delivery systems. SEM images displayed uniformly dispersed spherical particles, while TEM images and histograms provided valuable data about the size distribution of nanosilica, essential for applications like drug delivery. XRD analysis confirmed the crystalline nature of silica nanoparticles and offered insights into their crystallographic structure.

Conclusion:
This comprehensive study showed the synthesis and characterization of nanosilica and its antibiotic-coated variants, with a particular focus on TAP. The findings contribute to our understanding of their structural and compositional properties, providing potential avenues for applications in diverse scientific and technological fields, including drug delivery and nanotechnology.
Effect of Acidulated Phosphate Fluoride Gel on Zirconia Intaglio Surface: An In-Vitro Study
Authors: Hasan Nadia H. , Alkhalidi Emad Farhan , Qasim Ammar Abdulghani 
Published: October 2024

Abstract

Aim:
To evaluate the micro-shear bond strength (µ-SBS) of resin-modified glass ionomer cement and to assess the chemical and topographical changes in the zirconia fitting surface induced by acidulated phosphate fluoride (APF) gel using scanning electron microscope (SEM) analysis and Fourier transform infrared (FTIR) spectroscopy.

Materials and Methods:
Thirty-two samples were prepared from two zirconia materials, UPCERA HT White and BruxZir® Solid Zirconia, milled by a computer-aided design/computer-aided manufacturing system. From each zirconia sample, six plates were prepared for FTIR and SEM testing. Following sintering, the samples were divided into control and test groups for each material. The APF gel (1.23%) was applied to the intaglio surface of each test group. To measure the µ-SBS between the zirconia materials and luting cement, 20 rectangular samples of zirconia material were prepared. Ten samples were obtained from Upcera and ten from Bruxzir, with five assigned to the control and five to APF groups.

Statistical Analysis:
For the µ-SBS test, independent samples t test was conducted to determine the level of significance between the tested groups.

Results:
FTIR spectroscopy revealed new bands for Upcera and Bruxzir zirconia owing to ion exchange between the formed sodium phosphate and the zirconia surface and the formation of zirconium phosphate by an ester reaction. SEM assessment identified lines, scratches, or surface dissociation that appeared on the intaglio–zirconia surface after conditioning. The µ-SBS test, as indicated by the independent samples t test, showed a significant increase in bond strength of 1.266 and 1.566 MPa for Upcera and Bruxzir zirconia, respectively.

Conclusion:
This study offers new practical, cost-effective, and accurate tests to enhance the µ-SBS of luting cement to yttria-stabilized tetragonal zirconia polycrystal ceramics.
Repair Bond Strength of Composite Resin to Dental Ceramic Using Various Surface Treatments: An In Vitro Study
Authors: Al-Askary Raghad A. , Al-Ashou Wiaam M. O. , Hassoon Saif Nadhim 
Published: October 2024

Abstract

Aim:
This research aims to evaluate and compare the effect of various surface treatments and adhesive types on the bond strength between composite resin and two types of ceramic materials.

Materials and Methods:
A total of 98 disk-shaped of 10 mm diameter and 4 mm thickness were fabricated for each of the zirconia (H. C. Starck) and lithium disilicate (IPS E-Max computer-aided design), which were implanted individually in the acrylic resin mold leaving one surface exposed. The disks in each group were sub-divided according to the surface treatments into seven groups (n = 14): [hydrofluoric acid (HF, 9.5%), air abrasion, bur, laser, HF + bur, HF + air abrasion, HF + laser]. Each sub-group was further divided into two groups (n = 7) according to the type of adhesive used for the repairing procedure [G-Premio Bond universal adhesive group and intraoral repair kit (BISCO) group]. Each adhesive was applied depending on manufacturer instructions and, then, the composite cylinder (4 mm in diameter and 4 mm in height) was built on the pre-determined treated ceramic surface area by the addition of rubber mold. Then the samples were stored in distal water for 24 h. After that, all groups were submitted to a shear bond test using an Instron testing machine (TSTM 02500; Elista Ltd., Istanbul, Turkey) at 0.5 mm/min a crosshead speed. The data were analyzed by three-way analysis of variance and Tukey post hoc test at (P ≤ 0.05).

Results:
The HF + air abrasion groups registered the higher bond strength but with no statistically significant difference from groups of HF + bur. While the laser groups showed the lowest mean bond strength. Generally, E-Max registered significantly higher bond strength in comparison to zirconia. Finally, the BISCO repair system registered a significantly higher bond strength value in comparison to G-Premio.

Conclusion:
Combined surface treatment of HF + air abrasion with an intraoral repair kit can provide a promising method for repairing cracked ceramic restorations. However, repairing lithium disilicate is more predictable and successful than zirconia.
Prediction of Diabetes in Middle-Aged Adults: A Machine Learning Approach
Authors: Addo Gideon , Yeboah Bismark Amponsah , Obuobi Michael , Doh-Nani Raphael , Mohammed Seidu , Amakye David Kojo 
Published: October 2024

Abstract

Background:
Diabetes is a serious health concern requiring effective diagnostic strategies, particularly since its symptoms overlap with those of other conditions. Despite extensive research on early diabetes detection across various age groups, middle-aged adults have been relatively underexplored. This study focuses on this demographic to examine symptom-diabetes associations, examine the influence of symptoms in diabetes prediction, and determine an optimal machine learning (ML) model for diabetes prediction.

Materials and Methods:
This study utilized data from a previous cohort study conducted in Bangladesh. The original dataset included demographic and symptom-related information from 520 patients visiting the ABC Hospital in Bangladesh, India. The participants comprised both diabetic and non-diabetic individuals showing diabetes-like symptoms. For our study, data from 296 middle-aged adults (aged 40–60 years) were extracted. Chi-square tests assessed diabetes-symptom associations, and the Boruta algorithm examined feature influence. Seven ML classification models were evaluated for predictive accuracy.

Results:
Results showed that 60% of the 296 participants were diabetic. Symptoms like polyuria, polydipsia, weakness, sudden weight loss, partial paresis, polyphagia, and visual blurring were significantly associated with diabetes. All demographic and symptom-related features were influential in diabetes prediction, with polyuria, polydipsia, gender, alopecia, and irritability emerging as the most influential. Among the ML models tested, the random forest model exhibited the highest sensitivity (98.59%) and outperformed others in accuracy (96.58%) and area under the curve score (96.00%), making it the most efficient model for predicting diabetes in middle-aged adults.

Conclusion:
Diabetes associated symptoms provide valuable diagnostic opportunities for early diabetes detection in middle-aged adults. Future research should explore genetic, lifestyle, and environmental factors to improve diagnostic accuracy.