bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESCRIÇÃO DE RÓTULOS DE MEDICAMENTOS COMO ESTRATÉGIA PARA IDENTIFICAÇÃO DE MEDICAMENTOS FALSIFICADOS
Authors: Silva Augusto Santana Palma , Silva Sheila Torres Feitosa 
Published: October 2019

Medicamentos falsificados configuram problema de Saúde Pública ao expor a população a riscos relacionados ao uso de produtos com qualidade e segurança não verificáveis. O combate ao seu comércio compõe estratégia de ações da Vigilância Sanitária, órgão no qual o farmacêutico ocupa importante papel relacionado à identificação destes, ação extensível aos demais segmentos populacionais. O presente estudo tem com objetivo a descrição de rótulos de produtos apreendidos, evidenciando variáveis de fácil identificação e indicativa de ilicitudes por parte de não farmacêuticos. As apreensões realizadas pela equipe fiscalizadora ocorreram em drogarias situadas em município da Macrorregião Nordeste Brasileira em conformidade com as principais legislações vigentes acerca do tema. Dos quatro produtos apreendidos, dois referiam-se a óleo vegetal, um a cosmético e outro a suplemento alimentar. Óleos vegetais apresentaram informações falsas sobre o fabricante e os demais não apresentaram informações sobre o mesmo. Todos apresentaram finalidades ou ações terapêuticas, em não-conformidade às legislações sanitárias. Variáveis relacionadas ao fabricante, composição e finalidade de uso do produto podem compor estratégia de ampliação das ações fiscalizadoras relacionadas a produtos falsificados, ao se considerar ações de cunho educativo e orientador a proprietários de drogarias e usuários de medicamentos. É evidente a importância da apropriação do conhecimento por parte dos agentes, direta e indiretamente, envolvidos na cadeia terapêutica, em sintonia às diretrizes da Lei nº 8.080, de 19 de setembro de 1990, que trata a saúde como direto de todos e dever do Estado sem, contudo, excluir de membros da sociedade seus respectivos deveres para com a saúde de outrem.
A IMPORTÂNCIA DA AVALIAÇÃO DO CIRCUITO E GESTÃO DA MEDICAÇÃO NAS INSTITUIÇÕES DE LONGA PERMANÊNCIA PARA IDOSOS (ILPI): IDENTIFICAÇÃO DE PROBLEMAS RELACIONADO COM OS MEDICAMENTOS
Authors: Ferreira da Silva Renato , Vieira Carina 
Published: October 2019

Se avaliar procedimentos é importante em todas as áreas, na saúde a sua relevância tem um papel acrescido. Essa preocupação na criação de sistemas que permitam avaliar o circuito e gestão dos medicamentos em espaços onde residem idosos, assume uma importância que tem de ser devidamente enquadrada. É notório que muitos Problemas Relacionados com os Medicamentos (PRM) podem ser facilmente identificados quando existem sistemas integrados de controlo eficientes, diminuindo o risco de exposição a erros de medicamentos. Ao longo desta nota técnica, procuramos analisar alguns trabalhos publicados nos últimos anos, nest área. Diferentes estudos com diferentes protocolos, avaliaram múltiplas variáveis no circuito e gestão do medicamento em Instituições de Longa Permanência para Idosos (ILPI). Assim, da análise desses estudos, levantamos alguns pontos que podem e devem ser mais aprofundados no futuro, tendo o farmacêutico um papel ativo neste assunto.
Types, Tokens, and Hapaxes: A New Heap’s Law
Authors: Davis Victor 
Published: October 2019

Abstract
Heap’s Law
https://dl.acm.org/citation.cfm?id=539986 Heaps, H S 1978 Information Retrieval: Computational and Theoretical Aspects (Academic Press). states that in a large enough text corpus, the number of types as a function of tokens grows as N = K{M^\beta } for some free parameters K, \beta . Much has been written
http://iopscience.iop.org/article/10.1088/1367-2630/15/9/093033 Font-Clos, Francesc 2013 A scaling law beyond Zipf’s law and its relation to Heaps’ law (New Journal of Physics 15 093033).,
http://iopscience.iop.org/article/10.1088/1367-2630/11/12/123015 Bernhardsson S, da Rocha L E C and Minnhagen P 2009 The meta book and size-dependent properties of written language (New Journal of Physics 11 123015).,
http://iopscience.iop.org/article/10.1088/1742-5468/2011/07/P07013 Bernhardsson S, Ki Baek and Minnhagen 2011 A paradoxical property of the monkey book (Journal of Statistical Mechanics: Theory and Experiment, Volume 2011).,
http://milicka.cz/kestazeni/type-token_relation.pdf Milička, Jiří 2009 Type-token & Hapax-token Relation: A Combinatorial Model (Glottotheory. International Journal of Theoretical Linguistics 2 (1), 99–110).,
https://www.nature.com/articles/srep00943 Petersen, Alexander 2012 Languages cool as they expand: Allometric scaling and the decreasing need for new words (Scientific Reports volume 2, Article number: 943). about how this result and various generalizations can be derived from Zipf’s Law.
http://dx.doi.org/10.1037/h0052442 Zipf, George 1949 Human behavior and the principle of least effort (Reading: Addison-Wesley). Here we derive from first principles a completely novel expression of the type-token curve and prove its superior accuracy on real text. This expression naturally generalizes to equally accurate estimates for counting hapaxes and higher n-legomena.
Crystal structure of 3-acetyl-6-bromo-4-hydroxy-2H-chromen-2-one, C11H7BrO4
Authors: Hulushe Siya T. , Manyeruke Meloddy H. , Hosten Eric C. , Kaye Perry T. 
Published: October 2019

Abstract
C11H7BrO4, triclinic, P1̄ (no. 2), a = 4.3164(5) Å, b = 10.7922(12) Å, c = 11.1521(11) Å, α = 98.075(4)°, β = 100.741(4)°, γ = 95.325(5)°, V = 501.55(9) Å3, Z = 2, R
gt(F) = 0.0203, wR
ref(F
2) = 0.0544, T = 200(2) K.
Voicing control: A child resource for “growing a head taller”
Authors: Waring Hansun Zhang 
Published: October 2019

Abstract
Dinner times provide rich opportunities for overt and covert socialization. Drawing upon a larger corpus of 35 video-recorded family meals involving the three-year-old Zoe and her parents, this conversation analytic study describes how Zoe displays such agency through the practice of “voicing control” – momentarily sounding and acting like an adult by performing a range of controlling acts such as leading, instructing, advising, assessing, and mediating. I argue that by playing with such activities bound to the category of a higher position than hers, the child manages to grow “a head taller” in the Vygotskyan sense. The findings contribute to the budding literature on documenting socialization in naturalistic settings with a specific focus on the child’s role in such socialization.
Eating Disorders in Male Runners
Authors: Harris Julie , Peterson Janet T. 
Published: October 2019

ABSTRACTThis article aims to evaluate current literature related to the prevalence and consequences of eating disorders (EDs) among male runners. Historically, research was disproportionately aimed at female runners, hindering the assessment and clinical management of EDs in male runners. This literature review provides coaches with a deeper understanding of EDs in male runners. In addition, the physiological and psychological consequences attributed to a diagnosis of an ED in male runners are discussed. Suggestions for early identification and coaching strategies are provided. Future research is encouraged to provide a deeper understanding of the prevalence and significance of EDs in male runners.
Comparative Evaluation of Asphalt Pavement Dynamic Response with Different Bases under Moving Vehicular Loading
Authors: Ren Dongya , Song Hui , Huang Chao , Xiao Chuan , Ai Changfa 
Published: October 2019

Abstract
The horizontal strain at the bottom of asphalt concrete is well accepted as a key influencing factor in pavement performance and is directly related to fatigue cracking. This article presents the results of several studies performed in the field that focused on the evaluation of the effect of the base on the pavement dynamic responses under moving vehicular load through embedded strain gauges. Strain gauges were embedded at the bottom of the asphalt and base layers to measure pavement responses under moving vehicular loading. The investigated types of bases include a semirigid base, inverted base, compound base, and roller compacted concrete (RCC) base asphalt pavements. The effect of axle load level, tire pressure, and vehicle speed on pavement responses were analyzed based on the measured strain. Results showed that the critical horizontal strain at the bottom of the asphalt layer increased as the axle load increased, whereas the influence of the vehicle speed conversely affected the critical horizontal strain. The combined effect of the high temperature on the road surface and overload of the vehicle significantly increased the strain response at the bottom of the asphalt layer. Moreover, it was found that because of the modulus dependency of the pavement base, the horizontal strain at the bottom of both asphalt and base layers for RCC base pavement was smaller than that of the other three base types.
Additive Therapeutic Effects of Mesenchymal Stem Cells and IL-37 for Systemic Lupus Erythematosus
Authors: Xu Jianyong , Chen Jieting , Li Wenlei , Lian Wei , Huang Jieyong , Lai Baoyu , Li Lingyun , Huang Zhong 
Published: October 2019

Significance Statement
Although mesenchymal stem cells might have potential for treating SLE, their immunoregulatory plasticity renders their therapeutic effects unpredictable. The authors genetically modified mesenchymal stem cells to overexpress IL-37—a protein with immunosuppressive activity—and assessed the modified cells’ effects on immune suppression in vitro, as well as the effects of transplanting such cells into a mouse model of SLE. Mice transplanted with IL-37–overexpressing cells displayed improved survival and reduced signs of SLE compared with controls. Expression of IL-37 by mesenchymal stem cells can maintain higher serum levels of IL-37, and these cells had prolonged survival after transplantation, perhaps through IL-37 suppressing the inflammatory microenvironment. The additive therapeutic effects of this approach might offer a way to enhance the stability and effectiveness of mesenchymal stem cells in treating SLE.

Background
Although mesenchymal stem cells (MSCs) might offer a promising strategy for treating SLE, their immunoregulatory plasticity makes their therapeutic effects unpredictable. Whether overexpressing IL-37, an IL-1 family member with immunosuppressive activity, might enhance the therapeutic effects of these cells for SLE is unknown.

Methods
We genetically modified MSCs to overexpress IL-37 and assessed their effects on immune suppression in vitro. We also evaluated the effects of such cells versus effects of various controls after transplanting them into MRL/lpr mice (model of SLE).

Results
Stem cell characteristics did not appear altered in MSCs overexpressing IL-37. These cells had enhanced immunosuppression in vitro in terms of inhibiting splenocyte proliferation, reducing proinflammatory factors (IL-1β, TNF-α, IL-17, and IL-6), and suppressing autoantibodies (anti-dsDNA and anti-ANA). Compared with animals receiving control MSCs or IL-37 treatment alone, MRL/lpr mice transplanted with IL-37–overexpressing cells displayed improved survival and reduced signs of SLE (indicated by urine protein levels, spleen weight, and renal pathologic scores); they also had significantly lower expression of proinflammatory factors, lower total antibody levels in serum and urine, lower autoantibody production, and showed reduced T cell numbers in the serum and kidney. Expression of IL-37 by MSCs can maintain higher serum levels of IL-37, and MSCs had prolonged survival after transplantation, perhaps through IL-37 suppressing the inflammatory microenvironment.

Conclusions
Mutually reinforcing interaction between MSCs and IL-37 appears to underlie their additive therapeutic effects. Genetic modification to overexpress IL-37 might offer a way to enhance the stability and effectiveness of MSCs in treating SLE.
Efficacy and safety of lenvatinib in combination with everolimus in metastatic renal cell carcinoma resistant to antiangiogenic targeted therapy: Russian multicenter observational study ROSLERCM
Authors: Volkova M. I. , Abdelgafur A. M. , Aivazov M. T. , Amoev Z. V. , Babina K. G. , Borisov P. S. , Vorontsovа A. A. , Evstigneeva I. V. , Evsyukova O. I. , Zhelezin O. V. , Kalpinsky A. S. , Karabina E. V. , Kirdakova N. V. , Kolesnikov G. P. , Kuzmina E. S. , Latipova D. Kh. , Leonenkov R. V. , Maturov M. R. , Meskikh A. V. , Mishugin S. V. , Ovchinnikova E. G. , Olshanskaya A. S. , Protsenko S. A. , Semiglazova T. Yu. , Smirnov R. V. , Usynin E. A. , Fael M. M. , Cherniakova E. M. , Shumskaya I. E. 
Published: October 2019

Objective: an assessment of efficacy and safety of lenvatinib in combination with everolimus in unselected patients with metastatic renal cell carcinoma (mRCC) progressed during or following ≥1 line of antiangiogenic targeted therapy.Material. Russian multicenter observational study ROSLERCM included 73 consecutive patients with morphologically verified mRCC progressed during or following ≥1 line of antiangiogenic targeted therapy, treated with lenvatinib (18 mg/d) and everolimus (5 mg/d) in 20 Russian centers. Median age of the patients was 59 (23–73) years, a male-to-female ratio – 3:1. Most common histological type of kidney cancer was clear-cell RCC (71 (95.8 %)). More than 2 lines of previous therapy were administered in 45 (61.6 %) cases. Most patients were diagnosed with multiple metastases (71 (97.3 %)) in >1 site (61 (83.6 %)). Nephrectomy was performed in 87.7 % (64/73) of cases. At the combined therapy start ECOG PS 2–4 was registered in 16 (20.5 %), poor prognosis according to IMDC score – in 33 (45.2 %) patients. Median follow-up was 9.7 (1–26) months.Results. Median progression-free survival achieved 16.9 (95 % confidence intervals (CI) 12.1–20.6), overall survival – 20.8 (95 % CI 15.7–25.9) months. Objective response rate was 11 % (8/73); tumor control was reached in 93.2 % (68/73) of cases. Median objective response duration was 10.5 (4.3–16.8) months, tumor control duration – 10.0 (2.5–17.5) months. Any adverse events developed in 83.6 % (61/73), adverse events grade III–V – in 23.3 % (17/73) of cases. Most frequent AE grade III–IV were diarrhea (10 (13.6 %)) and arterial hypertension (6 (8.2 %)). Unacceptable toxicity demanded treatment cancellation in 4.2 % (3/73), therapy interruption – in 30.1 % (22/73) and dose reduction – in 32.9 % (24/73) of patients.Conclusion. Unselected mRCC patients administered with combined targeted therapy in the real world practice were registered with similar survival, lower objective response rate, and better tolerability comparing with population assigned for lenvatinib plus everolimus in the randomized phase II trial.
Assessment of methods of purification of corynebacterium allergen with definition of concentration and its experimental application
Authors: Baratov M. O. , Dzhambulatov Z. M. , Sakidibirov O. P. , Gadzhiyev B. M.-S. , Dzhabarova G. A. , Abduragimova R. M. 
Published: October 2019

Aim: Search for an effective method for obtaining bacterial protein and determining the optimal concentration for identification of specific types. Material and Methods. Using the example of a C. xerosis N 1911 reference strain grown on a nutrient medium improved by us, methods were investigated of protein precipitation with sodium chloride, ammonium sulphate, sodium hexametaphosphate, trichloroacetic acid and polyethylene glycol. The threshold sensitivity of the allergen in six different cultures was determined in tests on 24 guinea pigs infected with corynebaсteria. Biological activity was studied in cultures from 36 guinea pigs infected with M. BCG (Bacillus Calmette–Guérin vaccine), M. avium, C. xerosis N 1911, C. ulcerans N 675 and C. bovis, as well as 3 rabbits infected with Corynebacterium xerosis. Results. Comparative testing of five protein precipitation methods was carried out. When using ammonium sulphate as a precipitant relatively high results were obtained at a salt concentration of 30% and a pH of at least 5.8. More significant protein precipitation occurred at the isoelectric point of sodium chloride at pH 3.9. It was noted that trichloroacetic acid and sodium hexametaphosphate had insignificant precipitating properties while there was none with polyethylene glycol. The threshold sensitivity (0.00005 mg in 0.1 ml) and allergen unit of action (0.0003 mg) were established. Intensity of skin reaction to sensitin homologous to infection was detected. Conclusions. The data obtained revealed the optimal method of protein precipitation, the unit of action of the corynebacterium allergens, and expanded the understanding of the mechanisms of the sensitization of the macro‐organism to tuberculin.
Academic mobility of students as a factor in sustainability in higher education (the example of the Republic of Kazakhstan)
Authors: Maratova A. M. , Yakovenko N. V. , Kairlieva G. E. , Afonin Yu. A. , Utegenova K. T. , Voronin V. V. 
Published: October 2019

Aim. To reveal the features of the process of academic mobility as a factor in the sustainability of the higher education system (in the example of the Republic of Kazakhstan). Discussion. The organisation of student academic mobility is determined by the students striving to move for the purpose of academic exchange in the educational space and social adaptation in the framework of this process. The modeling of the organisation of academic mobility of students in higher education is a specific cognitive method in which the object of study is imitated in a model. A model of the academic mobility of students is presented in this article together with an exposition of its structural components and functionality. Conclusion.In the current situation in Kazakhstan outgoing academic mobility is of the greatest priority and acts as a mechanism to develop the intellectual potential and skills of the population. Incoming student mobility in Kazakhstan occupies a less significant position because of the weak material and technical base of Kazakhstan universities, underdeveloped services and infrastructure, limited abilities to provide education in English and visa restrictions. All this negatively affects the competitiveness of the Kazakhstan higher education system. In considering the indicators of international student exchange in the states of the Customs Union of the Eurasian Economic Union, it should be noted that outgoing mobility in Kazakhstan is more than two times higher than incoming, which impacts on the competitiveness of Kazakhstan universities in international mobility ratings. Effective organisation of the academic mobility of students in Kazakhstan will contribute to an increase in the influx of foreign students to its universities. It will also contribute to the formation of competitive specialists and their participation in the development of an advanced society and a knowledge‐based economy in the context of globalization, internationalisation and sustainable development.
Transformation of the socio‐ecological situation relating to HIV in the North Caucasus Federal District under the influence of external migration
Authors: Dmitriev R. V. 
Published: October 2019

Aim. The aim of the study is to identify the degree of external threat relating to the spread of HIV infection by migrants in the North Caucasus Federal District of Russia. Material and Methods. Systemic, comparative geographical, geographic and statistical research methods were applied, as well as MS Excel and SPSS Statistics software packages. The database was created for the periods 1997‐2000, 2003‐2006, 2007‐2010 and 2011‐2015. Four main (aggregated) groups of indicators were selected. Results. A hierarchical cluster analysis was undertaken on groups of indicators (the current situation in states studied regarding the spread of HIV, the flow of migrants from these states to the North Caucasus Federal District as a whole and its differentiation according to chronological and chorological characteristics) which made it possible to aggregate the countries of Asia and Africa into four groups according to threat level of the spread of HIV infection for the North Caucasus Federal District: (1) extremely high (post‐Soviet states of the Caucasus and Central Asia [excepting Turkmenistan]); (2) high (states of the eastern Mediterranean [excepting Lebanon], as well as Afghanistan and Turkmenistan); (3) countries of a medium degree of threat (most of the countries of sub‐Saharan Africa, Southeast Asia [except Vietnam, Laos, Cambodia, the Philippines and Brunei], as well as Pakistan); (4) low (all states). Conclusion. Despite the greater spread of HIV in African states compared with Asian states, it is the latter ‐ especially those formerly part of the USSR ‐ that pose the greatest threat to the North Caucasus Federal District with regard to the spread of HIV by migrants. Almost every state of origin of the majority of migrants infected with HIV has “its own” preferred destination in the North Caucasus Federal District, to which their inflows are oriented.
Condition of bottom sediment in the area of artificial islands of the Kashagan field, Kazakhstan
Authors: Kenzhegaliev K. , Kanbetov A. S. , Abylgazieva A. A. , Shakhmanova A. K. , Kulbatyrov   D. K. 
Published: October 2019

Aim.The aim of the research was to determine the pollution of bottom sediment with heavy metals around artificial islands A and D, where hydrocarbon raw materials from the subsalt stratum are being extracted from island D, and where production has not begun from island A. Investigations were carried out to compare the content of heavy metals in bottom sediments around these artificial islands. Material and Methods.The content of heavy metals Cd, Cr, Cu, Fe, Ni, Pb and Zn in the bottom sediment in the region of artificial islands A and D was studied. Samples were processed under laboratory conditions by standard methods. Measurement of the content of heavy metals Cd, Cr, Cu, Fe, Ni and Zn was made using an ICP‐MS spectrometer, and of Pb was made using a ContAA‐600 atomic absorption spectrometer with electrometric atomization (with a HydrEA System Batch Mode HS 55 modular hydride attachment). Results. In 2017, the average concentration of all studied elements in the region of island D was found to be higher than in the region of island A. Conclusion. In all seasons of the research, values in excess of the Maximum Permissible Concentration (MPC) of all pollutants was not found.
Features of transformation of organic matter in the forest reserves of the Crimea
Authors: Kobechinskaya V. G. , Yarosh O. B. , Ivashov A. V. , Apostolov V. L. 
Published: October 2019

Aim.The aim of the research was to identify the migration of ash elements and nitrogen in the leaf litter‐soil system for forest biogeocenoses of the Crimean mountains, taking into account the effect of the pyrogenic factor on pine forests of the Crimean Pine or Pallas Pine (Pinus nigra subsp. pallasiana D. Don) which occupy the largest areas. Material and Methods.Studies were conducted in the communities of the southern macroslope of the main ridge of the Crimean mountains in the territories of the Yalta Mountain‐Forest and Crimean Nature Reserves. A comparative analysis (taking into account vertical zonality) was carried out of the migration of chemical elements in the leaf litter‐soil system system at nine sample plots. Forest typological studies of the stand, chemical analysis of vegetation, soil sections and their physicochemical characteristics were carried out by generally accepted methods. Results.Differences in the series of accumulations of chemical elements were established for this territory for the first time. They vary significantly in each type of forest and have their own specificity that differentiates with regard to migration activity. Conclusions.It was shown that the processes of accumulation and decomposition of leaf‐fall and litter are components of the biological cycle of organic matter in protected areas of a large landscape complex – the southern macroslope of the main ridge of the Crimean mountains and can be considered as providing background monitoring data. This permits us to comprehend the environmental mechanisms of adaptation and the regulation of the structure and functions of these communities.