bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ornithine aminotransferase promoted the proliferation and metastasis of non‐small cell lung cancer via upregulation of miR‐21
Authors: Liu Yanfeng , Wu Lei , Li Kai , Liu Fengrui , Wang Li , Zhang Dongling , Zhou Jing , Ma Xuan , Wang Shengyu , Yang Shuanying 
Published: December 2018

AbstractThe incidence and mortality of lung cancer ranked the first among all types of cancer in China, and non‐small cell lung cancer (NSCLC) is the most common type of lung cancer accounting for 85% of all lung cancers. Given that the survival rate of patients with advanced NSCLC is still poor nowadays, identification of novel therapeutic targets and the development of effective therapies are desired for the treatment of NSCLC in clinics. In this study, we reported the upregulation of ornithine aminotransferase (OAT) in NSCLC cells and clinical tumor samples as well as its association with the advanced TNM stage, metastasis, and poor tumor differentiation of lung cancer. Using different NSCLC cell lines, we demonstrated that OAT promoted the proliferation, invasion, and migration, inhibited the apoptosis, and altered cell cycle of NSCLC cells; besides, the involvement of OAT‐miR‐21‐glycogen synthase kinase‐3β signaling in the functional role of OAT in NSCLC was also revealed. Importantly, in the absence of OAT, the growth and metastasis of tumor lung cancer xenograft was significantly suppressed in the nude mice. Based on our findings, OAT may be a potential novel biomarker for the diagnosis and therapeutic outcome monitoring of NSCLC. Inhibition of OAT may also represent a new therapeutic strategy of NSCLC.
Knockdown of DGCR5 enhances the radiosensitivity of human laryngeal carcinoma cells via inducing miR‐195
Authors: Tang Tian , Shan Guang , Zeng Feng 
Published: December 2018

AbstractLong noncoding RNAs (lncRNAs) exert critical roles in the development of various cancers, including human laryngeal cancer. Radioresistance contributes to the predominant causes of laryngeal cancer recurrence after radiotherapy. The aim of our study was to investigate the association of dysregulated lncRNA and radiation resistance in human larynx squamous carcinoma. Here, we investigated the biological roles of lncRNA DiGeorge syndrome critical region gene 5 (DGCR5) in radioresistance of human laryngeal cancer. Two human larynx squamous carcinoma cell lines (Hep‐2 and Hep‐2R), with different radiosensitivities in vitro were used in the present study. We observed that DGCR5 was significantly upregulated in Hep‐2R cells. Inhibition of DGCR5 by LV‐shDGCR5 transfection restrained Hep‐2R cell proliferation and sensitized cells to radiation. Reversely, overexpression of DGCR5 exhibited an opposite phenomenon in vitro. In addition, microRNA (miR)‐195 was predicted as a direct downstream target of DGCR5. Dual‐luciferase reporter and RNA immunoprecipitation assays verified the direct interaction between them. Meanwhile, miR‐195 was observed to be reduced in Hep‐2R cells and miR‐195 mimics repressed Hep‐2 cell growth. Moreover, radiosensitivity of Hep‐2R cells was greatly enhanced by overexpression of miR‐195, which could be reversed by upregulation of DGCR5. Finally, in vivo experiments were used to validate that knockdown of DGCR5 suppressed laryngeal carcinoma via targeting miR‐195. In conclusion, we indicated that DGCR5 could contribute to the radioresistance of human laryngeal carcinoma cells via sponging miR‐195.
Triangle‐free graphs that do not contain an induced subdivision of K4 are 3‐colorable
Authors: Chudnovsky Maria , Liu Chun‐Hung , Schaudt Oliver , Spirkl Sophie , Trotignon Nicolas , Vušković Kristina 
Published: December 2018

AbstractWe show that triangle‐free graphs that do not contain an induced subgraph isomorphic to a subdivision of are 3‐colorable. This proves a conjecture of Trotignon and Vušković [J. Graph Theory. 84 (2017), no. 3, pp. 233–248].
Supporting Creativity Or Conformity? Influence of Home Environment and Parental Factors on the Value of Children's Creativity Characteristics
Authors: Pugsley Lina , Acar Selcuk 
Published: December 2018

AbstractAlthough creativity is a desirable skill, parenting for creativity may be quite a challenge and may be less favored than parenting for conformity. The present study aims to investigate parent‐related factors that may support creativity versus conformity at home. To this end, this study examined how parents’ attitudes and values toward creativity, creative home environment, and mindful parenting style are related to parents’ perceptions of creative versus socially acceptable characteristics. Analyses of the data collected from 1324 parents (predominantly mothers) indicated that parents were more supportive of creativity traits than socially acceptable characteristics. Most importantly, parents’ attitudes and values toward creativity and creative home environment were significantly and positively related to support for creativity characteristics, whereas mindful parenting was significantly and negatively related to support for socially acceptable characteristics in children. Those findings show that parents who value creativity and set up a creative environment are more likely to support children's creativity. Mindful parenting style seems to indirectly support creativity because it is associated with lower respect for socially acceptable characteristics, some of which are at odds with creativity. Findings are discussed in terms of the implications for training programs that enhance awareness of creativity.
Effect of microheterogeneous environments of CTAB, Triton X‐100, and Tween 20 on the oxidative degradation of d‐fructose by nanoparticles of MnO2
Authors: Midya Jayanta K. , Ghosh Dinesh C. , Pal Biswajit , Sen Pratik K. 
Published: December 2018

AbstractThe kinetics of the oxidative degradation of d‐fructose by nanoparticles of MnO2 has been studied in dilute sulfuric acid medium and also in the presence of surfactants of cetyl trimethyl ammonium bromide (CTAB), Triton X‐100 (TX‐100), and Tween 20. Amorphous nanoparticles of MnO2 in the form of spherical particulates of size 50–200 nm, as detected by a transmission electron microscope, have been found to exist, supported on two‐dimensional gum acacia sheets. The reaction is first order in MnO2 but complex order with respect to fructose and H+. The reaction is inhibited due to adsorption of reaction products on the surface of MnO2 nanoparticles. The reaction takes place through an intermediate complex formation between β‐d‐fructopyranose and protonated MnO2. A one‐step two‐electron transfer reaction ultimately leads to the formation of an aldonic acid and formic acid. The entropy of activation plays the key role for the reaction in the absence of surfactants. In the surfactant‐mediated reaction, partitioning of both the reactants takes place between the aqueous and micellar pseudophases and reaction occurs following Berezin's model. Binding of fructose with the surfactants in the Stern/palisade layer takes place through the ion–dipole interaction and H‐bonding while protonated MnO2 remains at the outer side of the Stern/palisade layer within the micelle. Both the enthalpy and entropy changes associated with the fructose–water interaction, fructose–micelle interaction, and micelle–water interaction finally control the fructose–micelle binding.
A shell element for the prediction of residual load‐carrying capacities due to delamination
Authors: Gruttmann F. , Knust G. 
Published: December 2018

SummaryThis paper deals with layered plates and shells subjected to static loading. The kinematic assumptions are extended by a jump function in dependence of a damage parameter. Additionally, an intermediate layer is arranged at any position of the laminate. This allows numerical simulation of onset and growth of delaminations. The equations of the boundary value problem include besides the equilibrium in terms of stress resultants, the local equilibrium in terms of stresses, the geometric field equations, the constitutive equations, and a constraint which enforces the correct shape of a superposed displacement field through the thickness as well as boundary conditions. The weak form of the boundary value problem and the associated finite element formulation for quadrilaterals is derived. The developed shell element possesses the usual 5 or 6 degrees of freedom at the nodes. This is an essential feature since standard geometrical boundary conditions can be applied and the elements are applicable to shell intersection problems. With the developed model, residual load‐carrying capacities of layered shells due to delamination failure are computed.
p27Kip1 – p(RhoB)lematic in lung cancer
Authors: Podmirseg Silvio R , Vosper Jonathan , Hengst Ludger 
Published: December 2018

AbstractLung cancer is the leading cause of cancer mortality worldwide, with adenocarcinomas of the non‐small cell lung carcinoma (NSCLC) subtype accounting for the majority of cases. Therefore, an urgent need exists for a more detailed dissection of the molecular events driving NSCLC development and the identification of clinically relevant biomarkers. Even though originally identified as a tumour suppressor, recent studies associate the cytoplasmically (mis)localised CDK inhibitor p27Kip1(p27) with unfavourable responses to chemotherapy and poor outcomes in NSCLC, supporting the hypothesis that the protein can execute oncogenic activities. In a recent issue ofThe Journal of Pathology, Calvayrac and coworkers uncover a novel molecular mechanism that can explain this oncogenic role of p27. They demonstrate that cytoplasmic p27 binds and inhibits the small GTPase RhoB and thereby relieves a selection pressure for RhoB loss that is frequently observed in NSCLC. This is supported not only by studies with genetically modified mice, but also through identification of a cohort of human lung cancer patients with cytoplasmic p27 and continued RhoB expression, where this signature correlates with decreased survival. This not only establishes a potentially useful biomarker, but also provides yet another facet of the complex roles p27 undertakes in tumourigenesis. © 2018 The Authors.The Journal of Pathologypublished by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Synthesis, characterization, and antioxidant activities of imine compounds
Authors: Al Zoubi Wail , Al‐Hamdani Abbas Ali Salih , Duraid Ahmed Susan , Basheer Hassan M. , Al‐Luhaibi Roaa Sabti Awad , Dib Adnan , Ko Young Gun 
Published: December 2018

AbstractMonomeric complexes of the ligand H2L, with the general formula [M (HL2)2] with (M (II) = Co, Ni, Cu), have been synthesized and characterized by proton nuclear magnetic resonance (1H‐NMR), Fourier‐transform infrared spectroscopy (FT‐IR), ultraviolet–visible spectroscopy (UV‐Vis), elemental microanalysis, metal content, magnetic moment and molar conductance measurements, molar conductance, and chloride containing. On the basis of experimental evidences, tetrahedral geometry has been proposed for prepared Schiff bases complexes. The geometry of the ligand and its complexes were confirmed by their optimized structures obtained from the computational study. Antioxidant activities of these compounds were evaluated against 1.1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical and were compared with standard natural antioxidant, ascorbic acid. The results reveal that these compounds exhibit excellent radical scavenging activities.
Inhaled antibiotic use is associated with Scedosporium/Lomentospora species isolation in cystic fibrosis
Authors: Hong Gina , Lechtzin Noah , Hadjiliadis Denis , Kawut Steven M. 
Published: December 2018

AbstractIntroductionPrevalence of fungi has been rising in the cystic fibrosis (CF) population. Scedosporium species (spp) is the second most common mold seen in the CF respiratory tract. However, the characteristics associated with Scedosporium isolation and its clinical implications are poorly understood. The goal of this study was to determine clinical factors associated with Scedosporium spp to better understand the mechanisms that may contribute to the emergence of filamentous fungi in CF.MethodsWe conducted a retrospective cohort study of subjects followed in the CF Foundation Patient Registry between January 1, 2010 and December 31, 2012. Patients under 6 years of age, history of solid organ transplantation, and insufficient respiratory culture data were excluded. We used a multivariable logistic regression model to determine demographic data and baseline disease characteristics, medications and co‐infections associated with Scedosporium spp recovery in CF sputum.ResultsAmong 19 023 subjects, prevalence of Scedosporium spp was 615 (3.2%). Older age (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.07, 1.26) and white race (OR 1.69, 95% CI 1.09, 2.63) were the demographic factors associated with Scedosporium spp isolation. Inhaled antibiotic use had a significant association with Scedosporium isolation (OR 2.01, 95% CI 1.61, 2.52). For every additional course of intravenous antibiotics, the odds of Scedosporium isolation increased by 8% (OR 1.08, 95% CI 1.03, 1.14).ConclusionsThe association between inhaled antibiotics and Scedosporium informs us that chronic inhaled antibiotics may be playing a role in Scedosporium isolation. Further investigation to better characterize this relationship is necessary.
Prospective study of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia
Authors: Vayalthrikkovil Sakeer , Vorhies Erika , Stritzke Amelie , Bashir Rani A. , Mohammad Khorshid , Kamaluddeen Majeeda , Thomas Sumesh , Al Awad Essa , Murthy Prashanth , Soraisham Amuchou 
Published: December 2018

AbstractObjectiveTo evaluate the prevalence, risk factors, and optimal timing of echocardiogram for pulmonary hypertension (PH) in infants with bronchopulmonary dysplasia (BPD).DesignIn this prospective study, infants with gestational age (GA) <30 weeks admitted to a tertiary NICU between July 2015 and June 2017 who required positive pressure ventilation or oxygen therapy at ≥28 days of life were evaluated with serial echocardiograms at study enrollment (4‐6 weeks of age), 32 weeks (only for ≤25 weeks), 36, and 40 weeks post‐menstrual age (PMA) for PH.ResultsOf 126 infants (mean birth weight 858 ± 221 g; mean GA 26.1 ± 1.6 wks), 48 (38%) developed PH at any time during their hospital stay. The first study echocardiogram was performed at a median age of 31 weeks PMA. The prevalence of PH was 36/126 (28.5%) at enrollment, at 6/30 (20%) at 32 weeks, 24/111 (21.6%) at 36 weeks, and 10/59 (17%) at 40 weeks. No new cases of PH were identified at 40 weeks. At 36 weeks, none of the infants with mild BPD had PH, whereas 20% of moderate and 32% of severe BPD infants had PH. After controlling for confounding variables severe BPD (OR 3.31, 95%CI 1.12, 9.74), and ventilator associated pneumonia (VAP) (OR 17.9, 95%CI 3.9, 82.11) remained independent risk factors for BPD‐associated PH.ConclusionEchocardiographic screening for PH can be safely restricted to infants with moderate or severe BPD at 36 weeks PMA. We identified VAP as an independent risk factor for PH.
On normalized Laplacians, multiplicative degree‐Kirchhoff indices, and spanning trees of the linear [n]phenylenes and their dicyclobutadieno derivatives
Authors: Li Shuchao , Wei Wei , Yu Shiqun 
Published: December 2018

AbstractLet be the molecular graph of the linear [n]phenylene with n hexagons and n − 1 squares, and let be the graph obtained by attaching four‐membered rings to the terminal hexagons of . In this article, the normalized Laplacian spectrum of consisting of the eigenvalues of two symmetric tridiagonal matrices of order 3n is determined. An explicit closed‐form formula of the multiplicative degree‐Kirchhoff index (respectively the number of spanning trees) of is derived. Similarly, explicit closed‐form formulas of the multiplicative degree‐Kirchhoff index and the number of spanning trees of are obtained. It is interesting to see that the multiplicative degree‐Kirchhoff index of (respectively ) is approximately to one half of its Gutman index.
Carbene triel bonds between TrR3 (Tr = B, Al) and N‐heterocyclic carbenes
Authors: Chi Zongqing , Dong Wenbo , Li Qingzhong , Yang Xin , Scheiner Steve , Liu Shufeng 
Published: December 2018

AbstractThe carbene triel bond is predicted and characterized by theoretical calculations. The C lone pair of N‐heterocyclic carbenes (NHCs) is allowed to interact with the central triel atom of TrR3 (Tr = B and Al; R = H, F, Cl, and Br). The ensuing bond is very strong, with an interaction energy of nearly 90 kcal/mol. Replacement of the C lone pair by that of either N or Si weakens the binding. The bond is strengthened by electron‐withdrawing substituents on the triel atom, and the reverse occurs with substitution on the NHC. However, these effects do not strictly follow the typical pattern of F > Cl > Br. The TrR3 molecule suffers a good deal of geometric deformation, requiring on the order of 30 kcal/mol, in forming the complex. The R(C···Tr) bond is quite short, for example, 1.6 Å for Tr = B, and shows other indications of at least a partially covalent bond, such as a high electron density at the bond critical point and a good deal of intermolecular charge transfer.
Expanding the Alkaline Phosphatase Inhibition, Cytotoxic and Proapoptotic Profile of Biscoumarin‐Iminothiazole and Coumarin‐Triazolothiadiazine Conjugates
Authors: Iqbal Jamshed , Ejaz Syeda Abida , Ibrar Aliya , Umar Muhammad Ihtisham , Lecka Joanna , Sévigny Jean , Saeed Aamer 
Published: December 2018

AbstractThe present study was aimed to explore the inhibitory potential of coumarin‐hybrids bis‐coumarin‐iminothiazoles (5a‐k) and coumarin‐triazolothiadiazines (10a‐j) against both tissue‐nonspecific alkaline phosphatase (h‐TNAP) and intestinal alkaline phosphatase (h‐IAP) and to link their AP inhibitory potential with possible anti‐proliferative and pro‐apoptotic effect. All investigated compounds were potent inhibitors of h‐TNAP and h‐IAP with several fold better inhibition as compared to standard drugs. In bis‐coumarin‐iminothiazole series, 5f (IC50=0.35±0.01 μM) was found as a lead candidate against h‐TNAP demonstrating a ∼55‐fold higher inhibitory potential as compared to levamisole, whereas, among coumarin‐triazolothiadiazines, 10a (IC50=0.31±0.98 μM) showed ∼62‐fold inhibitory potential. Similarly, compounds 5g and 10d were most potent inhibitors of h‐IAP with an IC50 value of 0.22±0.87 and 0.56±0.04 μM, respectively. The detailed kinetic studies were conducted to probe the mechanism of inhibition. The four potent AP inhibitors 5f, 5h, 10a and 10g also showed maximum anti‐proliferative effect in cancer cells and apoptosis via G2/M phase arrest. 10a and 5f showed maximum cytotoxicity in K‐562 cells (89 and 80%, respectively) with IC50 values of about 2.37 and 7.81 μM, respectively. Our findings suggest these derivatives as potential anti‐cancer candidates with profound anti‐proliferative and pro‐apoptotic behavior along with the ability to block purinergic signaling.
Longitudinal change in cerebroplacental ratio in small‐for‐gestational‐age fetuses and risk of stillbirth
Authors: Kalafat E. , Ozturk E. , Sivanathan J. , Thilaganathan B. , Khalil A. 
Published: December 2018

ABSTRACTObjectiveTo investigate whether assessment of longitudinal change in Doppler variables in small‐for‐gestational‐age (SGA) fetuses improves the prediction of those at risk of stillbirth.MethodsThis was a longitudinal study of two cohorts of singleton pregnancies, which included SGA and appropriate‐for‐gestational‐age (AGA) fetuses, respectively. The inclusion criteria for the SGA cohort were singleton pregnancy at ≥ 20 weeks' gestation, classified as SGA (estimated fetal weight < 10th centile). The AGA cohort consisted of singleton pregnancies deemed at high risk of being SGA, which were followed up longitudinally but remained AGA. Fetal middle cerebral artery (MCA) pulsatility index (PI) and umbilical artery (UA)‐PI were measured longitudinally and cerebroplacental ratio (CPR) was calculated, and values were converted to multiples of the median. The last two measurements prior to delivery were included in the analysis. Longitudinal models for Doppler variables were developed using linear‐mixed models and their accuracy in the prediction of stillbirth was tested using generalized linear models. A Bayesian framework was employed to compare the accuracy of longitudinal and standard (last‐scan measurement) models.ResultsIn total, 1549 AGA and 941 SGA pregnancies were included in the analysis. There were 30 (3.2%) and no stillbirth cases in the SGA and AGA groups, respectively. Change in MCA‐PI, UA‐PI and CPR with advancing gestation was significantly different between liveborn AGA and SGA fetuses, with a less pronounced difference with advancing gestation. Using the last measurement, the best models for the prediction of stillbirth in SGA pregnancies were those based on CPR (accuracy, 75.0%; 95% CI, 72.6–77.2%) and UA‐PI (accuracy, 71.0%; 95% CI, 68.6–73.4%). The posterior probability of the standard CPR model having a higher accuracy compared with the UA‐PI model was 97.2% (magnitude of change (MC), 3.9%; 95% credible interval (CrI), 0.5–7.3%). The accuracies of the standard, compared with the longitudinal, models for UA‐PI (71.0% vs 72.8%), MCA‐PI (64.6% vs 63.8%) and CPR (75.0% vs 74.9%) in the prediction of stillbirth were not significantly different. The posterior probabilities for improvement in accuracy using longitudinal, compared with standard, assessment were 50.1% (MC, < 0.1%; 95% CrI, −3.3 to 3.3%), 35.2% (MC, −0.1%; 95% CrI, −4.5 to 2.8%) and 82.2% (MC, 1.9%; 95% CrI, −1.5 to 5.3%) for CPR, MCA‐PI and UA‐PI models, respectively. Therefore, change in Doppler parameters did not improve the accuracy of the prediction of stillbirth, compared with that of the last‐scan measurement.ConclusionLongitudinal assessment of Doppler parameters was not useful in improving the detection of stillbirth in SGA pregnancies, as compared with a single‐point assessment. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.
A new specimen of Prolacerta broomi from the lower Fremouw Formation (Early Triassic) of Antarctica, its biogeographical implications and a taxonomic revision
Authors: Spiekman Stephan N. F. 
Published: December 2018

AbstractProlacerta broomiis an Early Triassic archosauromorph of particular importance to the early evolution of archosaurs. It is well known from many specimens from South Africa and a few relatively small specimens from Antarctica. Here, a new articulated specimen from the Fremouw Formation of Antarctica is described in detail. It represents the largest specimen ofProlacertadescribed to date with a nearly fully articulated and complete postcranium in addition to four skull elements. The study of this specimen and the re-evaluation of otherProlacertaspecimens from both Antarctica and South Africa reveal several important new insights into its morphology, most notably regarding the premaxilla, manus, and pelvic girdle. Although well-preserved skull material from Antarctica is still lacking forProlacerta, a detailed comparison ofProlacertaspecimens from Antarctica and South Africa corroborates previous findings that there are no characters clearly distinguishing the specimens from these different regions and therefore the Antarctic material is assigned toProlacerta broomi. The biogeographical implications of these new findings are discussed. Finally, some osteological characters forProlacertaare revised and an updated diagnosis and phylogenetic analysis are provided.