bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of a wire-driven parallel robot for wind tunnel test based on the analysis of stiffness and workspace
Authors: Ji Yangfeng , Peng Miaojiao , Lin Qi 
Published: November 2024

AbstractThis paper presents an eight wire-driven parallel robot (WDPR-8) designed to serve as a suspension manipulator for aircraft models during wind tunnel testing. The precision of these tests is significantly influenced by the system’s stability and workspace, both of which are shaped by the geometric configuration of the structure and the tension in the wires. To acquire the efficiency principle of the suspension scheme design for the model, a kinematics model for a WDPR-8 was established. Based on the kinematics model, the stiffness of a WDPR-8 was theoretically studied, and the analytical expression of stiffness matrix of a WDPR was deduced. The stiffness matrix was composed of two terms, one of which is determined by the configuration of suspension system and the other term is determined by the wire tension. Based on the analysis result, a set of suspension scheme was discussed under the calculation of stiffness matrix and workspace analysis. In the discussion process, in addition to the stiffness-maximum calculation, another criterion as force closure is presented, which is useful for increasing the stiffness and workspace of the robot. Finally, a prototype was established according to the analysis result, and the workspace experiments are conducted. Test results indicate that the workspace meets the design requirements, validating the system suspension design method of a WDPR for aircraft model suspension in wind tunnel test considering of the systematic stiffness and workspace.
An infant case of coronary artery aneurysms with no systemic symptoms after treatment for Kawasaki disease
Authors: Asai Yumiko , Suzuki Takanori , Yamada Midori 
Published: November 2024

AbstractThis case is a 4-month-old patient with Kawasaki disease who showed coronary artery lesions after a disease relapse. Following the guidelines from the Randomised Controlled Trial to Assess Immunoglobulin plus Steroid Efficacy, the patient initially saw an improvement in symptoms. However, a relapse occurred despite low levels of C-reactive protein, leading to significant coronary artery growth. Treatment with a third dose of intravenous immunoglobulin and cyclosporine led to a slow reduction in the size of the coronary artery abnormalities. This case highlights the difficulty in monitoring Kawasaki disease progression through clinical symptoms and C-reactive protein levels alone. We also emphasise the necessity of echocardiographic monitoring in patients receiving anti-inflammatory treatments, including steroids, because coronary artery problems can arise or continue without the usual signs of Kawasaki disease or increased C-reactive protein levels.
Making space for grief: The impact of remembrance programs for pediatric healthcare providers
Authors: Wiener Lori , Nautiyal Parinita , McAdams Stacey , Zoosman Mike 
Published: November 2024

Abstract

Objectives
While caring for seriously ill children is a rewarding experience, pediatric healthcare providers may experience sadness and emotional distress when their patient dies. These feelings, particularly when not addressed, can lead to negative health and occupational outcomes. Remembrance practices can provide a safe space for staff to process their grief. This study explored pediatric healthcare providers’ perceptions of an annual Pediatric Remembrance Ceremony (PRC) and a quarterly program, Good Grief and Chocolate at Noon (GGCN), to learn what components of the programs were considered meaningful and the personal impact on those who attended. The programs pivoted to a virtual platform during the COVID-19 pandemic, and the study also assessed providers’ perspectives of attending the programs virtually.

Methods
A 19 multiple choice survey instrument was designed, reviewed, piloted, revised, and re-piloted by an interdisciplinary bereavement committee prior to administration. The survey included 2 open-ended questions, inviting additional insights into personal impact and future directions for remembrance programs. The survey was administered on an encrypted online platform.

Results
Components of the PRC respondents most valued included the opportunity for staff to choose a name of a patient they cared for and to light a candle for that patient as their name is read. Those who participated in GGCN found story sharing helpful, along with having a speaker address a topic around loss and grief during the second half of the session. Both programs provided reflection, solidarity, and memorialization. Most respondents prefer having both in-person and virtual options.

Significance of results
Healthcare providers are affected by the death of the children they care for and value opportunities provided to join colleagues in remembering their patients. The findings underscore the value of remembrance programs in supporting bereaved staff.
Prospects of Predicting the Polar Motion Based on the Results of the Second Earth Orientation Parameters Prediction Comparison Campaign
Authors: Kur Tomasz , Śliwińska‐Bronowicz Justyna , Wińska Malgorzata , Dobslaw Henryk , Nastula Jolanta , Partyka Aleksander , Belda Santiago , Bizouard Christian , Boggs Dale , Bruni Sara , Chen Lue , Chin Mike , Dhar Sujata , Dill Robert , Duan PengShuo , Ferrandiz Jose M. , Gou Junyang , Gross Richard , Guessoum Sonia , Han Songtao , Heinkelmann Robert , Huang ChengLi , Irrgang Christopher , Kudrys Jacek , Li Jia , Ligas Marcin , Liu Lintao , Lu Weitao , Mayer Volker , Miao Wei , Michalczak Maciej , Modiri Sadegh , Otten Michiel , Ratcliff Todd , Raut Shrishail , Saynisch‐Wagner Jan , Schartner Matthias , Schoenemann Erik , Schuh Harald , Shahvandi M. Kiani , Soja Benedikt , Su Xiaoqing , Thaller Daniela , Thomas Maik , Wang Guocheng , Wu Yuanwei , Xu CanCan , Xu Xueqing , Yang Xinyu , Zhao Xin , Zhou Zhijin 
Published: November 2024

AbstractGrowing interest in Earth Orientation Parameters (EOP) resulted in various approaches to the EOP prediction algorithms, as well as in the exploitation of distinct input data, including the observed EOP values from various operational data centers and modeled effective angular momentum functions. Considering these developments and recently emerged new methodologies, the Second Earth Orientation Parameters Prediction Comparison Campaign (2nd EOP PCC) was pursued in 2021–2022. The campaign was led by Centrum Badań Kosmicznych Polskiej Akademii Nauk in cooperation with Deutsches GeoForschungsZentrum and under the auspices of the International Earth Rotation and Reference Systems Service. This paper provides the analysis and evaluation of the polar motion predictions submitted during the 2nd EOP PCC with the prediction horizons between 10 and 30 days. Our analysis shows that predictions are highly reliable with only a few occasional discrepancies identified in the submitted files. We demonstrate the accuracy of EOP predictions by (a) calculating the mean absolute error relative to polar motion observations from September 2021 through December 2022 and (b) assessing the stability of the predictions in time. The analysis shows unequal results for the x and y components of polar motion (PMx and PMy, respectively). Predictions of PMy are usually more accurate and have a smaller spread across all submitted files when compared to PMx. We present an analysis of similarity between the participants to indicate what methods and input data give comparable output. We also prepared the ranking of prediction methods for polar motion summarizing the achievements of the campaign.
Seasonal and Local Time Variation in the Observed Peak of the Meteor Altitude Distributions by Meteor Radars
Authors: Dawkins E. C. M. , Janches D. , Stober G. , Carrillo‐Sánchez J. D. , Lieberman R. S. , Jacobi C. , Moffat‐Griffin T. , Mitchell N. J. , Cobbett N. , Batista P. P. , Andrioli V. F. , Buriti R. A. , Murphy D. J. , Kero J. , Gulbrandsen N. , Tsutsumi M. , Kozlovsky A. , Lester M. , Kim J.‐H. , Lee C. , Liu A. , Fuller B. , O’Connor D. , Palo S. E. , Taylor M. J. , Marino J. , Rainville N. 
Published: November 2024

AbstractMeteoroids of sub‐milligram sizes burn up high in the Earth's atmosphere and cause streaks of plasma trails detectable by meteor radars. The altitude at which these trails, or meteors, form depends on a number of factors including atmospheric density and the astronomical source populations from which these meteoroids originate. A previous study has shown that the altitude of these meteors is affected by long‐term linear trends and the 11‐year solar cycle related to changes in our atmosphere. In this work, we examine how shorter diurnal and seasonal variations in the altitude distribution of meteors are dependent on the geographical location at which the measurements are performed. We use meteoroid altitude data from 18 independent meteor radar stations at a broad range of latitudes and investigate whether there are local time (LT) and seasonal variations in the altitude of the peak meteor height, defined as the majority detection altitude of all meteors within a certain period, which differ from those expected purely from the variation in the visibility of their astronomical source. We find a consistent LT and seasonal response for the Northern Hemisphere locations regardless of latitude. However, the Southern Hemisphere locations exhibit much greater LT and seasonal variation. In particular, we find a complex response in the four stations located within the Southern Andes region, which indicates that the strong dynamical atmospheric activity, such as the gravity waves prevalent here, disrupts, and masks the seasonality and dependence on the astronomical sources.
Mid‐Latitude Study of Ionospheric Variation Over Iran Associated With Equatorial Ionization Anomaly (EIA), and Artificial Neural Networks Model Development
Authors: Vazifehkhah Hafteh M. , Mahmoudian A. , Yoshikawa A. , Girgis K. 
Published: November 2024

AbstractThe ionosphere over Iran is located on the upper edge of equatorial ionization anomaly (EIA). The Equatorial Electrojet (EEJ) as the proxy of temporal evolution of the EIA is explored using the MAGDAS stations near the magnetic equator during quiet and active geomagnetic conditions. The possible impact of EIA on Total Electron Content (TEC) over Iran is investigated. Analyzing data from 140 stations over 7 months, it is found that EEJ influences TEC and its latitudinal penetration. During geomagnetically active days, EEJ's behavior and TEC's latitudinal variations are investigated. Diurnal EEJ patterns and counter electrojets (CEJ) are analyzed, alongside solar wind timing effects on EEJ and TEC using data from stations in Brazil, Peru, the Philippines, and Sri Lanka. Statistical correlations between maximum TEC and parameters extracted from the daily EEJ profile, including EEJ, integrated EEJ (IEEJ), and IEEJ—highlight Iran's position at the EIA's upper edge, indicating high susceptibility to equatorial dynamics. In addition, the Rate of Total Electron Content Index (ROTI) has been analyzed under geomagnetic active conditions. The results demonstrate that ROTI exhibits good agreement with TEC in terms of latitude penetration and the detected gradient in TEC. Employing Artificial Neural Networks (ANN) for local TEC prediction, Iran is segmented into eight regions based on GNSS receiver distribution. Each region's ANN model, trained during the quiet geomagnetic condition, assesses predictability and accuracy. The ANN model demonstrates reliable local TEC forecasting and confirms the direct impact of equatorial dynamics on Iran's ionosphere.
High-density, high-frequency and large-scale electrohydrodynamic drop-on-demand jetting via a protruding polymer-based printhead design
Authors: Duan Yongqing , Yang Weili , Wang Qiming , Sun Zhaoyang , Guo Haoyu , Yin Zhouping 
Published: November 2024

AbstractElectrohydrodynamic (EHD) printing has critical merits in micro/nanoscale additive manufacturing because of its ultrahigh resolution and wide ink compatibility, making it an advantageous choice for electronics manufacturing, high-resolution prototyping, and biological component fabrication. However, EHD printing is currently limited by its rather low throughput due to the lack of high-frequency and high-density multi-nozzle printheads. This paper presents a novel EHD printhead with a protruding polymer-based nozzle design. An insulated, hydrophobic, and protruding polymer nozzle array with an appropriate geometric structure can effectively address key problems in multi-nozzle jetting, such as electrical crosstalk, electrical discharge, liquid flooding, and nonuniform jetting. By investigating the influence of the electrical and geometric characteristics of the nozzle arrays on the electrical crosstalk behavior and fabricating the optimized nozzle array via MEMS technology, we achieve an EHD printhead with a large scale (256), high density (127 dpi), and high jetting frequency (23 kHz), and addressable jetting can be realized by adding independently controllable extractors underneath the nozzle array. Many functional materials, such as quantum dots, perovskite, and nanosilver inks, can be ejected into high-resolution patterns through the optimized nozzle array, demonstrating the great prospects of our designed printhead in electronics manufacturing. This MEMS-compatible printhead design lays the foundation for high-throughput fabrication of micro/nanostructures and promotes practical applications of EHD printing in functional electronics and biomedical/energy devices.
USP3 promotes DNA damage response and chemotherapy resistance through stabilizing and deubiquitinating SMARCA5 in prostate cancer
Authors: Li Sheng , Xiong Situ , Li Zhongqi , Yang Lin , Yang Hailang , Xiong Jing , Pan Wang , Guo Ju , Xu Songhui , Fu Bin 
Published: November 2024

AbstractThe chromatin-remodeling enzyme SMARCA5 plays a key role in DNA-templated events including transcription, DNA replication, and DNA repair. Loss of function of the SMARCA5 can cause neurodevelopmental disorder and Williams syndrome. However, the molecular mechanism underlying the regulation of SMARCA5 in prostate cancer remains largely elusive. Here, we report that the deubiquitinating enzyme USP3 directly interacts with SMARCA5 and removes K63-linked polyubiquitination of SMARCA5 to maintain its stability, which promotes DNA damage repair and chemotherapy resistance. Depletion of USP3 or SMARCA5 promoted PCa cells sensitive to docetaxel and overexpression of USP3 restored the cells resistance to docetaxel treatment in SMARCA5 silenced cells in vitro and vivo. Clinically, USP3 was significantly up-regulated in prostate cancer tissues and positively associated with SMARCA5 expression. Collectively, our findings uncover a novel molecular mechanism for the USP3-SMARCA5 axis in regulating DSB repair with an important role in chemotherapy response in human prostate cancers, highlighting that targeting USP3-SMARCA5 axis could be a valuable strategy to treat USP3/SMARCA5-overexpressing chemotherapy-resistant patients and improve drug treatment.
On the nature of hydrogen bonding in the H2S dimer
Authors: Jäger Svenja , Khatri Jai , Meyer Philipp , Henkel Stefan , Schwaab Gerhard , Nandi Apurba , Pandey Priyanka , Barlow Kayleigh R. , Perkins Morgan A. , Tschumper Gregory S. , Bowman Joel M. , van der Avoird Ad , Havenith Martina 
Published: November 2024

AbstractHydrogen bonding is a central concept in chemistry and biochemistry, and so it continues to attract intense study. Here, we examine hydrogen bonding in the H2S dimer, in comparison with the well-studied water dimer, in unprecedented detail. We record a mass-selected IR spectrum of the H2S dimer in superfluid helium nanodroplets. We are able to resolve a rotational substructure in each of the three distinct bands and, based on it, assign these to vibration-rotation-tunneling transitions of a single intramolecular vibration. With the use of high-level potential and dipole-moment surfaces we compute the vibration-rotation-tunneling dynamics and far-infrared spectrum with rigorous quantum methods. Intramolecular mode Vibrational Self-Consistent-Field and Configuration-Interaction calculations provide the frequencies and intensities of the four SH-stretch modes, with a focus on the most intense, the donor bound SH mode which yields the experimentally observed bands. We show that the intermolecular modes in the H2S dimer are substantially more delocalized and more strongly mixed than in the water dimer. The less directional nature of the hydrogen bonding can be quantified in terms of weaker electrostatic and more important dispersion interactions. The present study reconciles all previous spectroscopic data, and serves as a sensitive test for the potential and dipole-moment surfaces.
Repeat-based holocentromeres of the woodrush Luzula sylvatica reveal insights into the evolutionary transition to holocentricity
Authors: Mata-Sucre Yennifer , Krátká Marie , Oliveira Ludmila , Neumann Pavel , Macas Jiří , Schubert Veit , Huettel Bruno , Kejnovský Eduard , Houben Andreas , Pedrosa-Harand Andrea , Souza Gustavo , Marques André 
Published: November 2024

AbstractIn most studied eukaryotes, chromosomes are monocentric, with centromere activity confined to a single region. However, the rush family (Juncaceae) includes species with both monocentric (Juncus) and holocentric (Luzula) chromosomes, where centromere activity is distributed along the entire chromosome length. Here, we combine chromosome-scale genome assembly, epigenetic analysis, immuno-FISH and super-resolution microscopy to study the transition to holocentricity in Luzula sylvatica. We report repeat-based holocentromeres with an irregular distribution of features along the chromosomes. Luzula sylvatica holocentromeres are predominantly associated with two satellite DNA repeats (Lusy1 and Lusy2), while CENH3 also binds satellite-free gene-poor regions. Comparative repeat analysis suggests that Lusy1 plays a crucial role in centromere function across most Luzula species. Furthermore, synteny analysis between L. sylvatica (n = 6) and Juncus effusus (n = 21) suggests that holocentric chromosomes in Luzula could have arisen from chromosome fusions of ancestral monocentric chromosomes, accompanied by the expansion of CENH3-associated satellite repeats.
Atomically precise copper clusters with dual sites for highly chemoselective and efficient hydroboration
Authors: Jia Teng , Ai Jie , Li Xiaoguang , Zhang Miao-Miao , Hua Yue , Li Yi-Xin , Sun Cai-Fang , Liu Feng , Huang Ren-Wu , Wang Zheng , Zang Shuang-Quan 
Published: November 2024

AbstractThe hydroboration of alkynes into vinylboronate esters is a vital transformation, but achieving high chemoselectivity of targeted functional groups and an appreciable turnover number is a considerable challenge. Herein, we develop two dynamically regulating dual-catalytic-site copper clusters (Cu4NC and Cu8NC) bearing N-heterocyclic thione ligands that endow Cu4NC and Cu8NC catalysts with performance. In particular, the performance of microcrystalline Cu4NC in hydroboration is characterized by a high turnover number (77786), a high chemoselectivity, high recovery and reusability under mild conditions. Mechanistic studies and density functional theory calculations reveal that, compared with the Cu8NC catalyst, the Cu4NC catalyst has a lower activation energy for hydroboration, accounting for its high catalytic activity. This work reveals that precisely constructed cluster catalysts with dual catalytic sites may provide a way to substantially improve catalytic properties by fully leveraging synergistic interactions and dynamic ligand effects, thus promoting the development of cluster catalysts.
Systemic inflammation accelerates neurodegeneration in a rat model of Parkinson’s disease overexpressing human alpha synuclein
Authors: Massaro Cenere Mariangela , Tiberi Marta , Paldino Emanuela , D’Addario Sebastian Luca , Federici Mauro , Giacomet Cecilia , Cutuli Debora , Matteocci Alessandro , Cossa Francesca , Zarrilli Beatrice , Casadei Nicolas , Ledonne Ada , Petrosini Laura , Berretta Nicola , Fusco Francesca Romana , Chiurchiù Valerio , Mercuri Nicola B. 
Published: November 2024

AbstractIncreasing efforts have been made to elucidate how genetic and environmental factors interact in Parkinson’s disease (PD). In the present study, we assessed the development of symptoms on a genetic PD rat model that overexpresses human α-synuclein (Snca+/+) at a presymptomatic age, exposed to a pro-inflammatory insult by intraperitoneal injection of lipopolysaccharide (LPS), using immunohistology, high-dimensional flow cytometry, constant potential amperometry, and behavioral analyses. A single injection of LPS into WT and Snca+/+ rats triggered long-lasting increase in the activation of pro-inflammatory microglial markers, monocytes, and T lymphocytes. However, only LPS Snca+/+ rats showed dopaminergic neuronal loss in the substantia nigra pars compacta (SNpc), associated with a reduction in the release of evoked dopamine in the striatum. No significant changes were observed in the behavioral domain. We propose our double-hit animal as a reliable model to investigate the mechanisms whereby α-synuclein and inflammation interact to promote neurodegeneration in PD.
Well Pattern optimization as a planning process using a novel developed optimization algorithm
Authors: Zaheri Seyed Hayan , Hosseini Mahdi , Fathinasab Mohammad 
Published: November 2024

AbstractDetermination of optimum well location and operational settings for existing and new wells is crucial for maximizing production in field development. These optimum conditions depend on geological and petrophysical factors, fluid flow regimes, and economic variables. However, conducting numerous simulations for various parameters can be time-consuming and costly. Also, due to the high dimension of the possible solutions, there is still no general approach to address this problem. The application of searching algorithm as a general approach to solve such problems has received much attention in recent years. In this study, the efficiency, and reliability of genetic algorithm, particle swarm optimization and in particular a newly developed algorithm was analyzed and compared. The novelty of this work is the integrated algorithm, which improves searching performance by leveraging the memorizing characteristics of the particle swarm optimization algorithm to enhance genetic algorithm efficiency. In traditional genetic algorithms, solutions lacking adequate qualifications are deleted from the algorithmic process; however, the new algorithm provides these solutions with additional opportunities to prove themselves by acquiring new velocities from particle swarm optimization. The results indicate that while the genetic algorithm and particle swarm optimization do not guarantee optimal outcomes, the newly developed algorithm outperforms both methods. This performance was tested across various scenarios focused on well pattern optimization, highlighting its innovative contribution to the field development.