bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Incidence of Postpartum Post‐Traumatic Stress Disorder in Women Exposed to Adverse Childhood Experiences: A Systematic Review and Meta‐Analysis
Authors: Zou Linli , Wang Shu , Chen Jingfen , Krewski Daniel , Wen Shi Wu , Lai Xiaolu , Xie Ri‐hua 
Published: November 2024

ABSTRACTBackgroundAdverse childhood experiences (ACEs) are known contributors to lifelong mental health challenges. Despite studies linking ACEs to increased risk of adverse postpartum mental health outcomes, a systematic review on the occurrence of postpartum post‐traumatic stress disorder (PTSD) in women with ACEs is lacking.MethodsA systematic search was conducted in seven databases to retrieve studies from inception to January 31, 2024. A random‐effects model was used to quantify weighted estimates of postpartum PTSD incidence. Statistical analysis was conducted using R software.ResultsSeven studies were included in the system review. One study was identified as an outlier and excluded from the meta‐analysis. Among the six remaining studies, 1186 women exposed to ACEs were identified, with 249 of them experiencing postpartum PTSD. The estimated incidence of postpartum PTSD among women exposed to ACEs was 22.6% (95% confidence interval [CI] 16.1%–29.8%). Subgroup analysis revealed significant variations in incidence depending on study settings (p < 0.01) and PTSD assessment methods (p < 0.01). Due to multicollinearity among the primary variables, a meta‐regression to identify factors influencing study heterogeneity was not conducted.ConclusionThe incidence of postpartum PTSD was 22.6% in women with ACEs, higher than that observed in the general obstetric population. This finding suggests the need to provide comprehensive postpartum care for these women.
Academic language use in middle school informational writing
Authors: Sarmiento Cherish M. , Truckenmiller Adrea J. , Cho Eunsoo , Wang Heqiao 
Published: November 2024

AbstractBackgroundLearning to write the complex academic language (AL) associated with a discipline (like science) is a critical task in education, with middle school being a key developmental period. However, we need more research to guide how we assess students' learning to write AL, especially if we want to create assessment that guides more effective instruction.AimsWe evaluated middle school students' informational writing for six different measures of AL to determine which ones were most strongly related to writing quality and were most indicative of the unique features of informational writing. We also examined which metrics were sensitive to growth across middle school.SampleOur sample consists of informational compositions from 285 students in Grade 5 (n = 175) and Grade 8 (n = 110) in a Midwestern state in the United States.MethodsPath modelling was used to determine the degree to which the AL metrics are associated with writing quality and narrativity in each grade.ResultsOverall, the six measures of AL explained 70% of the variance in students' writing quality. We found that a new measure, number of long words, outperformed other more established measures at the word level and should be used in assessment of informational writing quality. We also found that automated scores at the sentence level better detected development across middle school grade levels than typical rubrics of writing quality.ConclusionResults provide promising avenues for the assessment of malleable aspects of AL in middle school informational writing.
Fibrocytes in tumor microenvironment: Identification of their fraction and novel therapeutic strategy
Authors: Mitsuhashi Atsushi , Nishioka Yasuhiko 
Published: November 2024

AbstractFibrocytes were identified as bone marrow‐derived myeloid cells that also have fibroblast‐like phenotypes, such as ECM production and differentiation to myofibroblasts. Although fibrocytes are known to contribute to various types of tissue fibrosis, their functions in the tumor microenvironment are unclear. We focused on fibrocytes as pivotal regulators of tumor progression. Our previous studies have indicated that fibrocytes induce angiogenesis and cancer stem cell‐like phenotypes by secreting various growth factors. In contrast, immune checkpoint inhibitor (ICI)‐treated fibrocytes demonstrated antigen‐presenting capacity and enhanced antitumor T cell proliferation. Taken together, these findings indicate that fibrocytes have multiple effects on tumor progression. However, the detailed phenotypes of fibrocytes have not been fully elucidated because the isolation of distinct fibrocyte clusters has not been achieved without culturing in ECM‐coated conditions or intracellular staining of ECM. The development of single‐cell analyses partially resolves these problems. Single‐cell RNA sequences in CD45+ immune cells from tumor tissue identified ECM‐expressing myeloid‐like cells as distinct fibrocyte clusters. In addition, these findings enabled the isolation of tumor‐infiltrating fibrocytes as CD45+CD34+ cells. These tumor‐infiltrating fibrocytes demonstrated both antigen‐presenting ability and differentiation into myofibroblast‐like cancer‐associated fibroblasts. Considering these functions of fibrocytes in tumor progression, molecular‐targeting agents for the migration, activity, and differentiation of fibrocytes are promising therapeutic strategies. Furthermore, identification of specific cell surface markers and master regulators of fibrocytes will advance novel fibrocyte‐targeting therapies. In this review, we discuss the multiple roles of tumor‐infiltrating fibrocytes and novel cancer therapeutic strategies.
Translation, Reliability and Development of a Calculator for the Brazilian Portuguese Version of the Family Empowerment Scale (FES) in Caregivers of Individuals With Cerebral Palsy
Authors: Santos Acsa Soares , Silva Luana Cristina da , Muniz Maria Eduarda , Farah Felipe , Souto Deisiane Oliveira , de Almeida Rithelly Barbosa , de Matos Mariana Aguiar , Chagas Paula Silva de Carvalho , Leite Hércules Ribeiro 
Published: November 2024

ABSTRACTIntroductionCare for patients with cerebral palsy (CP) poses significant challenges, with emphasis on the crucial role of family involvement in patients' well‐being. The Family Empowerment Scale (FES) assesses parents/caregivers' perception of their ability to promote and influence their children's development in three domains: family, service system and community.ObjectivesThe objectives of this study were to translate the FES into Brazilian Portuguese, to develop a calculator for data transformation and analysis and to evaluate the psychometric properties of the scale with Brazilian caregivers of children and adolescents with CP.MethodsTranslation occurred in four stages: translation, synthesis, back‐translation and review of the translated version. A calculator was then developed in the Excel program, to present data in absolute values and graphically for each subscale. Statistical analysis included Bland–Altman, Intraclass Correlation Coefficient (ICC), Internal Consistency, and Floor and Ceiling Effect.ResultsIn total, 50 parents and caregivers participated to the measurement properties investigation, and the scale demonstrated good reliability for the family (ICC = 0.80) and services (ICC = 0.81) subscales, as well as for the overall scale (ICC = 0.88). The community subscale showed moderate reliability (ICC = 0.68), with an adequate Cronbach's alpha (0.89). The FES showed no ceiling or floor effects and a small limit of agreement. The data of all participants were analysed using the calculator.ConclusionThe FES‐Brazilian Portuguese presented good reliability for assessing family empowerment in caregivers of children and adolescents with CP in Brazil, offering insights into this construct and guiding family‐centred interventions. In addition, the calculator could be viable for adequate management and dissemination of data.
Featured Cover
Authors: Luo Yuwen , Li Jun , Zheng Lv , Reyimjan Yizaitiguli , Ma Yan , Huang Shuaixiang , Liu Hongyu , Zhou Guizhen , Bai Jiachen , Zhu Yixiao , Sun Yidan , Zou Xinhua , Hou Yunpeng , Fu Xiangwei 
Published: November 2024

The cover image is based on the article Procyanidin B2 improves developmental capacity of bovine oocytes via promoting PPARγ/UCP1‐mediated uncoupling lipid catabolism during in vitro maturation by Yuwen Luo et al., https://doi.org/10.1111/cpr.13687.
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Melanoma Diagnosis in the Mihm Era—And Beyond
Authors: Elder David E. 
Published: November 2024

ABSTRACTDuring the illustrious career of Martin C. Mihm Jr., MD, the diagnosis of melanoma underwent significant changes, to which he made many contributions. In early descriptions, melanomas were fungating tumor masses that were obviously malignant, and highly lethal. In seminal work by Dr. Mihm and his mentor, Wallace H. Clark, Jr., MD, the early phases of development of these neoplasms were recognized and distinguished from the more advanced disease. It was generally believed that the early stage of melanoma, termed radial growth phase (RGP) and characterized by absence of vertical growth phase (VGP) and by favorable microstaging attributes could be recognized, excised, and cured, thus preventing the development of advanced disease. However, strenuous efforts in this direction over several decades have resulted in little or no change in mortality, leading to the recognition that many of these neoplasms, at least, may not be true biological malignancies, and to the conclusion that overdiagnosis commonly occurs in this disease, which is defined as representing diagnosis as melanoma of a neoplasm that would not have had the capacity to cause death or symptoms in the lifetime of the host. Although there may be other subsets of neoplasms in this category, an important category of overdiagnosis in melanomas is concentrated in T1a melanomas that lack VGP. If these neoplasms can be recognized with sensitive and specific criteria, which may already be available, changes in terminology may be appropriate, recognizing that some of them may have low malignant potential, whereas others may have no capacity at all for metastasis and may not warrant the use of the term “melanoma.”
Non‐clinical and first‐in‐human characterization of ECC5004/AZD5004, a novel once‐daily, oral small‐molecule GLP‐1 receptor agonist
Authors: Haggag Amina Z. , Xu Jianfeng , Butcher Laurie , Pagnussat Sandra , Davies Graeme , Lundqvist Sara , Wang Wenyu , Van Zuydam Natalie , Nelander Karin , Jha Aruni , Yu Hongtao , Boianelli Alessandro , Lindmark Bosse , Ollerstam Anna , Sun Xuefeng , Wang Fan , Pan Xiaoliang , Liu Haihui , Chen Wengang , Xu Jianfeng , Wallenius Kristina , Zhou Jingye 
Published: November 2024

AbstractAimsGLP‐1 receptor agonists (GLP‐1 RAs) are proven therapies for type 2 diabetes mellitus (T2DM) and overweight or obesity. We performed non‐clinical and first‐in‐human (FIH) evaluation of ECC5004/AZD5004, an oral small‐molecule GLP‐1 RA.Materials and MethodsECC5004 was profiled in cell lines overexpressing human GLP‐1R, in glucose‐stimulated insulin secretion (GSIS) assays in a human β‐cell line and non‐human primates (NHPs). To evaluate safety, ECC5004 was orally administered to NHPs for 9 months and a phase I, double‐blind, placebo‐controlled FIH study was conducted. This study evaluated single doses of ECC5004 (1–300 mg) in healthy volunteers, and multiple daily doses (5, 10, 30 and 50 mg) in patients with T2DM for 28 days.ResultsECC5004 bound to the hGLP‐1R (IC50 = 2.4 nM) augmented cAMP signalling without β‐arrestin‐2 recruitment or receptor internalization. ECC5004 potentiated GSIS in both EndoC‐βH5 cells (EC50 = 5.9 nM) and in vivo in NHPs (EC50 = 0.022 nM). Dose‐dependent body weight changes compared to control were seen in the 9‐month NHP toxicity study. In the first‐in‐human study, ECC5004 was well tolerated with no serious adverse events. Dose‐dependent reductions in glucose and body weight were observed with a dose‐proportional exposure at doses ≥25 mg.ConclusionECC5004 engaged the GLP‐1R across the therapeutic dose range tested and had a safety and tolerability profile consistent with other GLP‐1 RAs, along with a pharmacokinetic profile compatible with once‐daily oral dosing. These data support continued development of ECC5004 as a potential therapy for T2DM and overweight or obesity. Clinical trial registration: NCT05654831.
Parental depressive symptoms and child psychopathology: Effects of parenting‐specific emotion regulation and emotion socialization
Authors: Rodriguez Violeta J. , Zegarac Miriam C. , Brumbaugh Taylor S. , La Barrie Dominique L. , Terry Jenna B. , Shaffer Anne 
Published: November 2024

AbstractObjectiveThe study explores the associations among parental depressive symptoms, child symptoms of psychopathology, emotion socialization (ES), and parenting‐specific emotion regulation (ER) using a novel measure, the Regulating Emotions in Parenting Scale (REPS).BackgroundThere is a notable correlation between parental depressive symptoms and symptoms of psychopathology in children. Empirical studies have also observed a correlation in the intergenerational patterns of ER, as well as their relations to ES. Investigating these relations in nonclinical samples is vital for understanding these risk factors and how they relate to child mental health.MethodThe study sample was comprised of n = 315 mothers and fathers and used a cross‐sectional design. Assessments were conducted on parental depressive symptoms, child psychopathology, ES, and parenting‐specific ER (REPS).ResultsOur findings revealed that parental depressive symptoms were significantly associated with all ER strategies in the parenting context. These ER strategies, in turn, were related to unsupportive ES practices, which were further related to child psychopathology. Parenting‐specific ER strategies and parents' supportive ES had a significant indirect effect on the association between parental depressive symptoms and child psychopathology. However, only indirect effects through unsupportive ES and suppression and rumination were significant, not adaptive ER.ConclusionsThe study's cross‐sectional correlations provide support for the role of parenting‐specific ER as it relates to ES, parental, and child psychopathology.ImplicationsFindings imply that how parents regulate their emotions during parenting significantly affects their ability to engage in supportive ES practices, but replication in a longitudinal framework is warranted.
Facilitating acculturation of internationally educated nurses: A meta‐synthesis of social integration strategies
Authors: Foo Huili Eugenia , Goh Yong Shian 
Published: November 2024

AbstractAimTo explore the social integration strategies adopted by internationally educated nurses during acculturation and to elucidate their role in facilitating successful adaptation to their host countries.BackgroundWith their remarkable resilience, internationally educated nurses navigate numerous challenges in their acculturation process in the host country.IntroductionWhile the importance of effective social integration strategies in the acculturation and subsequent retention of internationally educated nurses is well known, the specific strategies adopted by these nurses have not been extensively explored. This study aims to fill this gap with its unique and significant focus on these strategies.MethodsEight electronic databases were searched for English articles from inception to October 2023 to ensure a comprehensive review. The quality of the included studies was appraised using the Critical Appraisal Skills Program checklist. A meta‐synthesis was performed using Sandelowski and Barroso's two‐step approach, and a thematic analysis was performed according to Braun and Clarke's framework.FindingsThis review included experiences of 258 internationally educated nurses across 16 primary studies and has yielded the overarching theme of ‘fostering a sense of belonging’. The overarching theme is supported by three themes: (1) cultivating social capital, (2) employing effective communications, and (3) engaging with the community.DiscussionInternationally educated nurses' social integration is a complex process that leverages support networks, establishing connections and overcoming communication barriers. However, the most crucial element is the active involvement of the host community, which plays a significant role in internationally educated nurses’ acculturation journey.Conclusion and implications for nursing practiceThis review has highlighted the importance of social integration in internationally educated nurses’ acculturation journey. Interventions such as having a supportive social network, providing a customised communication programme, organising engagement activities and granting overseas home leave are practical strategies that can enhance this journey.
Experiences of Nurses Speaking Up in Healthcare Settings: A Qualitative Metasynthesis
Authors: Lee Eunhee , De Gagne Jennie C. , Randall Paige S. , Tuttle Brandi , Kwon Hyunjeong 
Published: November 2024

ABSTRACTAimTo systematically review and synthesise qualitative research on nurses' experiences of speaking up in various contexts and to identify factors facilitating or impeding such a behaviour.DesignThis review was conducted as a qualitative metasynthesis, utilising the qualitative meta‐ethnography approach.MethodsA total of 6250 articles were screened. Two reviewers screened titles, abstracts and full texts. A total of 15 studies were included in this review. Researchers conducted a quality appraisal using the JBI critical appraisal checklist for qualitative research. An a priori protocol was created and registered on the Open Science Framework.Data SourcesLiterature searches were conducted in five international bibliographic databases (MEDLINE, Embase, PsycINFO, CINAHL and ProQuest Dissertations and Theses Global) and five Korean databases (RISS, KISS, DBpia, KCI and NDSL).ResultsThree main themes were identified from the 15 studies used in the metasynthesis: (1) decisional complexity of speaking up, (2) motivators for speaking up and (3) barriers to speaking up. Nurses experienced challenges in speaking up. They were, and continue to be, concerned about negative responses. Hierarchy structure and poor work environment were identified as barriers to speaking up; professional responsibility and a supportive atmosphere were identified as facilitators for speaking up.ConclusionsThis review synthesised nurses' experiences of speaking up and influencing factors. Speaking up is crucial for nurses to improve patient safety, as frontline nurses are ideally positioned to observe early indicators of unsafe conditions in healthcare delivery.ImpactIdentified motivators and barriers of nurses' speaking‐up behaviour offer considerations and opportunities for healthcare leaders and managers. This could lead to improvement in patient safety through the establishment of a safety culture that facilitates nurses' speaking‐up behaviour.Reporting MethodThe review adhered to the ENTREQ guideline.Patient or Public ContributionNo patient or public contribution has been made in this review.
Prognosis and clinicopathological features of patients with early‐onset and late‐onset colorectal cancer with second primary malignancies
Authors: Chen Fan , Chen Jiayu , Luo Dakui , Zhang Ruijia , Yang Yufei , Li Qingguo , Li Xinxiang 
Published: November 2024

AbstractBackground and AimThe risk of developing a second primary malignancy differs among colorectal cancer patients in different age groups. This study aimed to investigate the differences in prognosis and clinicopathological features of patients with early‐onset colorectal cancer and late‐onset colorectal cancer who developed second primary malignancies.MethodsThe study included 15 489 patients who underwent surgery for colorectal cancer at Fudan University Shanghai Cancer Center between January 2008 and December 2018. Data pertaining to these patients were derived from the database.ResultsA total of 680 (4.5%) patients subsequently developed a second primary malignancy. Considering death as a competing event, the 10‐year cumulative risk of second primary malignancy for early‐onset colorectal cancer was 5.3%, compared with 7.3% for late‐onset colorectal cancer. Cox analysis showed that late‐onset colorectal cancer, colon cancer, smaller tumor size, and fewer tumor nodules without residual lymph node structure, chemotherapy, and radiotherapy were independent risk factors for second primary malignancy. In our patient cohort, early‐onset colorectal cancer was associated with better prognosis compared to late‐onset colorectal cancer, for both overall survival and second primary malignancy‐free survival. In addition, there was insufficient evidence that early‐onset colorectal cancer also affected prognosis after the occurrence of second primary malignancies.ConclusionsThe risk of early‐onset colorectal cancer subsequently developing second primary malignancy was significantly lower than late‐onset colorectal cancer, and the second primary malignancies of early‐onset colorectal cancer were more likely to be colorectal cancer. Overall survival and second primary malignancy‐free survival of early‐onset colorectal cancer were consistently better than late‐onset colorectal cancer.
Does War Make States? Military Spending and the Italian State‐Building, 1861–1945
Authors: Pistoresi Barbara , Salsano Francesco , Incerpi Andrea 
Published: November 2024

ABSTRACTWe present empirical evidence on the relationship between military spending and the expansion of other government budget items and tax revenues from the unification of Italy (1861) up to the end of World War II. Until 1922, investments in education and social transfers to families mainly moved in step with defence spending. This means that increases in defence spending imply an increase in both education spending and transfers. Moreover, transfers also play a compensatory role during recessions. Increases in defence spending do not crowd out investment in capital expenditure, while disinvestment in defence is associated with an increase in investment in capital. The pro‐cyclical behaviour of tax revenues is compatible with the debt‐financing dynamic of much government expenditure. Although our analytical narrative is not universally valid, it does support the persistent centrality of external wars in the discontinuous growth and expansion of central government in the Italian state, with some exceptions explained by historical events.
The Bidirectionality of Pragmatic Transfer in Chinese English Language Learners' Compliment Responses: The Effects of Second Language Proficiency
Authors: Zhang Ying 
Published: November 2024

AbstractA handful of second language (L2) studies have explored bidirectional pragmatic transfer: forward pragmatic transfer—the influence of learners' first language (L1) on their L2—and reverse pragmatic transfer—the impact of learners' L2 on their L1. This explanatory sequential mixed‐methods study investigated how L2 proficiency influenced the bidirectionality of pragmatic transfer in compliment responses. Thirty‐four intermediate English‐as‐a‐foreign‐language (EFL) learners and 34 advanced EFL learners were recruited from a university in China. The results of computer‐mediated communication via WeChat showed that, similar to L1 Chinese speakers, the intermediate learners tended to deny compliments in English, indicating forward pragmatic transfer. Like L1 English speakers, the advanced learners frequently accepted compliments in Chinese, suggesting reverse pragmatic transfer. Furthermore, when responding to compliments in Chinese or English, some advanced learners preferred to accept compliments first and then deny them. Findings from interviews revealed that identity and language prestige might affect bidirectional pragmatic transfer.