bluuebunny/crossref_metadata_2025_split huggingface dataset:
A reduced Gompertz model for predicting tumor age using a population approach
Authors: Vaghi C. , Rodallec A. , Fanciullino R. , Ciccolini J. , Mochel J. , Mastri M. , Poignard C. , Ebos J. ML , Benzekry S. 
Published: June 2019

AbstractTumor growth curves are classically modeled by ordinary differential equations. In analyzing the Gompertz model several studies have reported a striking correlation between the two parameters of the model.We analyzed tumor growth kinetics within the statistical framework of nonlinear mixed-effects (population approach). This allowed for the simultaneous modeling of tumor dynamics and interanimal variability. Experimental data comprised three animal models of breast and lung cancers, with 843 measurements in 94 animals. Candidate models of tumor growth included the Exponential, Logistic and Gompertz. The Exponential and – more notably – Logistic models failed to describe the experimental data whereas the Gompertz model generated very good fits. The population-level correlation between the Gompertz parameters was further confirmed in our analysis (R2> 0.96 in all groups). Combining this structural correlation with rigorous population parameter estimation, we propose a novel reduced Gompertz function consisting of a single individual parameter. Leveraging the population approach using bayesian inference, we estimated the time of tumor initiation using three late measurement timepoints. The reduced Gompertz model was found to exhibit the best results, with drastic improvements when using bayesian inference as compared to likelihood maximization alone, for both accuracy and precision. Specifically, mean accuracy was 12.1% versus 74.1% and mean precision was 15.2 days versus 186 days, for the breast cancer cell line.These results offer promising clinical perspectives for the personalized prediction of tumor age from limited data at diagnosis. In turn, such predictions could be helpful for assessing the extent of invisible metastasis at the time of diagnosis.Author summaryMathematical models for tumor growth kinetics have been widely used since several decades but mostly fitted to individual or average growth curves. Here we compared three classical models (Exponential, Logistic and Gompertz) using a population approach, which accounts for inter-animal variability. The Exponential and the Logistic models failed to fit the experimental data while the Gompertz model showed excellent descriptive power. Moreover, the strong correlation between the two parameters of the Gompertz equation motivated a simplification of the model, the reduced Gompertz model, with a single individual parameter and equal descriptive power. Combining the mixed-effects approach with Bayesian inference, we predicted the age of individual tumors with only few late measurements. Thanks to its simplicity, the reduced Gompertz model showed superior predictive power. Although our method remains to be extended to clinical data, these results are promising for the personalized estimation of the age of a tumor from limited measurements at diagnosis. Such predictions could contribute to the development of computational models for metastasis.
Phylogenetic correlations can suffice to infer protein partners from sequences
Authors: Marmier Guillaume , Weigt Martin , Bitbol Anne-Florence 
Published: June 2019

AbstractDetermining which proteins interact together is crucial to a systems-level understanding of the cell. Recently, algorithms based on Direct Coupling Analysis (DCA) pairwise maximum-entropy models have allowed to identify interaction partners among the paralogs of ubiquitous prokaryotic proteins families, starting from sequence data alone. Since DCA allows to infer the three-dimensional structure of protein complexes, its success in predicting protein-protein interactions could be mainly based on contacting residues coevolving to remain physicochemically complementary. However, interacting proteins often possess similar evolutionary histories, which also gives rise to correlations among their sequences. What is the role of purely phylogenetic correlations in the performance of DCA-based methods to infer interaction partners? To address this question, we employ controlled synthetic data that only involves phylogeny and no interactions or contacts. We find that DCA accurately identifies the pairs of synthetic sequences that only share evolutionary history. It performs as well as methods explicitly based on sequence similarity, and even slightly better with large and accurate training sets. We further demonstrate the ability of these various methods to correctly predict pairings among actual paralogous proteins with genome proximity but no known direct physical interaction, which illustrates the importance of phylogenetic correlations in real data. However, for actually interacting and strongly coevolving proteins, DCA and mutual information outperform sequence similarity.Author summaryMany biologically important protein-protein interactions are conserved over evolutionary time scales. This leads to two different signals that can be used to computationally predict interactions between protein families and to identify specific interaction partners. First, the shared evolutionary history leads to highly similar phylogenetic relationships between interacting proteins of the two families. Second, the need to keep the interaction surfaces of partner proteins biophysically compatible causes a correlated amino-acid usage of interface residues. Employing simulated data, we show that the shared history alone can be used to detect partner proteins. Similar accuracies are achieved by algorithms comparing phylogenetic relationships and by coevolutionary methods based on Direct Coupling Analysis, which are a priori designed to detect the second type of signal. Using real sequence data, we show that in cases with shared evolutionary but without known physical interactions, both methods work with similar accuracy, while for physically interacting systems, methods based on correlated amino-acid usage outperform purely phylogenetic ones.
Effects of primary school’s physical environment on children’s spatial perception and behavior
Authors: Türel Ahmet , Ayşe Gür Elmira 
Published: June 2019

Purpose
The relationship between the child and his/her physical environment is an area of interaction that includes social, psychological and cultural factors along with the spatial experience, perception and behavior of the child. This study is based on the effects of spatial perception and behavior of the child within the physical environment of primary schools. In this direction, the purpose of this paper is to investigate how spatial and physical characteristics of primary school typologies affect the spatial perception and behavior of the child. Also, the parameters affecting spatial perception and behavior are examined.

Design/methodology/approach
The question to be investigated is how the spatial and physical characteristics of the school’s physical environment affect the child’s spatial perception and behavior in primary schools with different typologies. Within this scope, Istanbul’s Kagithane region is selected as a case study. Schools are chosen for their similar spatial and dimensional features and similar socio-economic environment. The methodology of the study consists of a literature review, an observational study carried out to discover the interaction between the child and his/her school building and the analysis of the student’s cognitive maps. These maps were evaluated according to topological, projective, metric and imaginative parameters.

Findings
The results show spatial organization and physical characteristics of primary school buildings with a structure that allows for change and transformation, and contributes to the physical and cognitive development of children.

Originality/value
This study will provide an opportunity to develop the design of future primary school buildings that can support the spatial perception and spatial experiences of the children.
A parallel high-order compressible flows solver with domain decomposition method in the generalized curvilinear coordinates system
Authors: Piquet Arthur , Zebiri Boubakr , Hadjadj Abdellah , Safdari Shadloo Mostafa 
Published: June 2019

Purpose
This paper aims to present the development of a highly parallel finite-difference computational fluid dynamics code in generalized curvilinear coordinates system. The objectives are to handle internal and external flows in fairly complex geometries including shock waves, compressible turbulence and heat transfer.

Design/methodology/approach
The code is equipped with high-order discretization schemes to improve the computational accuracy of the solution algorithm. Besides, a new method to deal with the geometrical singularities, so-called domain decomposition method (DDM), is implemented. The DDM consists of using two different meshes communicating with each other, where the base mesh is Cartesian and the overlapped one a hollow cylinder.

Findings
The robustness of the present implemented code is appraised through several numerical test cases including a vortex advection, supersonic compressible flow over a cylinder, Poiseuille flow, turbulent channel and pipe flows. The results obtained here are in an excellent agreement when compared to the experimental data and the previous direct numerical simulation (DNS). As for the DDM strategy, it was successful as simulation time is clearly decreased and the connection between the two subdomains does not create spurious oscillations.

Originality/value
In sum, the developed solver was capable of solving, accurately and with high-precision, two- and three-dimensional compressible flows including fairly complex geometries. It is noted that the data provided by the DNS of supersonic pipe flows are not abundant in the literature and therefore will be available online for the community.
Teaching performance assessments in the USA and Australia
Authors: Charteris Jennifer 
Published: June 2019

Purpose
Teaching performance assessments (TPAs) have developed in the USA and Australia as a “bar exam” for the profession and are used means to assure that graduates are classroom ready. The purpose of this paper is to outline how these assessments have been implemented in teacher education in the USA and Australian contexts. The edTPA is embroiled in controversy in the USA and there are important lessons from the related research literature that could inform the how other countries engage with TPAs in pre-service teacher education.

Design/methodology/approach
This conceptual paper outlines how Australia has introduced TPAs in initial teacher education (ITE) through policy borrowing from the USA. The paper synthesises critiques of the edTPA (USA) from research literature and considers the implications of TPAs in the Australian context.

Findings
The TPA impacts the focus of pre-service teacher practicum teaching, and pedagogy and curriculum in ITE education. The TPA could be used to mobilise detrimental accountability mechanisms. With the outsourcing of assessment to edu-business, Pearson Education, teacher education institutions in the USA have a sense that they have lost control over determining which students are credentialed to teach. Although pre-service teacher assessment is still administered and assessed by ITE institutions in Australia, there is a concern that could change. It is argued that educators, administrators and policy makers should avoid moves to outsource TPAs in Australia.

Originality/value
Because it is in its infancy, there is a little robust research into the implication of introducing teacher performance assessments into the Australian teacher education context.
Estimation of expected years of life lost for patients with ischemic stroke and intracerebral hemorrhage
Authors: Butsing Nipaporn , Tipayamongkholgul Mathuros , Ratanakorn Disya 
Published: June 2019

Purpose
The purpose of this paper is to estimate the mean life expectancy (LE) and the expected years of life lost (EYLL) for ischemic stroke and intracerebral hemorrhage.

Design/methodology/approach
This retrospective cohort study included 5,210 patients with a diagnosis of first ischemic stroke or intracerebral hemorrhage between 2005 and 2013 from Ramathibodi Hospital, Bangkok, Thailand. The survival of each case was followed until December 31, 2016. A semiparametric extrapolation method was applied to estimate the lifetime survival function relative to an age and sex-matched reference population.

Findings
Of 5,210 patients, 74.2 percent experienced ischemic stroke. About 54.3 percent were men. Mean age at diagnosis was 64.3 years. The mean LE was 12.5 years for ischemic stroke and 12.0 years for intracerebral hemorrhage. The EYLL among patients with intracerebral hemorrhage was significantly higher than among those with ischemic stroke (10.1 vs 5.7). Women were expected to lose more LE than men for both types of stroke (p-value<0.05), while younger aged patients were expected to lose more years of life than older ones.

Originality/value
This study fulfilled an identified need to estimate LE and EYLL among patients with ischemic stroke and intracerebral hemorrhage.
Is there still a gender effect on CEO compensation?
Authors: Leszczynska Dorota , Chandon Jean-Louis 
Published: June 2019

Purpose
Do female CEOs face a compensation gap? The purpose of this paper is to examine whether gender affects the total compensation of today’s CEOs, and whether it moderates ten factors influencing their total compensation.

Design/methodology/approach
Taking the 54 female CEOs cited in the US 2014 Fortune’s 1000 report, a matched sample of male CEOs was selected, matched according to the crosstab of age by education and by the sizes of the companies directed by these female CEOs.

Findings
Using four years’ worth of Fortune reports, between 2013 and 2016, this matched sample indicates that female CEOs are not discriminated against in terms of total compensation. However, eight factors do show a significant effect on total compensation. Using moderation analysis, the present study reveals how gender interacts with company size, sector, membership of outside boards and nature of previous experience.

Research limitations/implications
This paper addresses an important and under-researched gap, with contradictory findings in the existing literature, by compiling and testing the characteristics of male and female CEOs which are not cited in Fortune 1000 reports.

Originality/value
Arguably, this is therefore one of the first papers to study gender differences in total compensation among Fortune 1000 CEOs using a matched sample technique, based on a larger number of female CEOs and a larger number of years than any previous research.
Thermal creep of shear tab connection assemblies under transient-state temperatures of fire
Authors: Al Khatib Karim , Hantouche Elie , Morovat Mohammed Ali 
Published: June 2019

PurposeThis study aims to investigate the thermal creep behavior of steel frame assemblies with shear tab connections subjected to transient-state fire temperatures. Different key parameters are investigated to study their effect on the global response of the steel frames in fire.Design/methodology/approachFinite element (FE) models of connection assemblies are first analyzed using Abaqus under transient-state temperature conditions and validated against experimental work available in the literature. Upon acquiring the validated conditions, parametric studies are carried out to study the effect of key geometric and heating parameters on the overall response of the frame assembly to fire temperatures. Thermal creep material is also incorporated in the analyses through a user-defined subroutine, and a comparison between including and excluding creep material is illustrated to show the effect of thermal creep on the structural behavior.FindingsThe results reported herein indicate that having a rigid column increases the thermal-induced axial forces, thus increasing the development of thermal creep strains. Slow heating rates can cause axial stress relaxation in the restrained beam and increase the mid-span deflection and consequently the development of beam catenary action. The results also show that reaching higher initial cooling temperatures and having longer cooling phase durations result in more tensile forces at the end of the cooling phase.Originality/valuePrevious studies were limited to isolated steel connections under steady-state conditions. This study investigates the creep behavior of shear tab connection assemblies under transient-state conditions of fire when creep effects are explicitly considered. This can provide a rational and realistic assessment of the steel behavior in fire events.
Workplace learning in crowdwork
Authors: Margaryan Anoush 
Published: June 2019

PurposeThis paper aims to explore workplace learning practices within two types of crowdwork – microwork and online freelancing. Specifically, the paper scopes and compares the use of workplace learning activities (WLAs) and self-regulatory learning (SRL) strategies undertaken by microworkers (MWs) and online freelancers (OFs). We hypothesised that there may be quantitative differences in the use of WLAs and SRL strategies within these two types of crowdwork, because of the underpinning differences in the complexity of tasks and skill requirements.Design/methodology/approachTo test this hypothesis, a questionnaire survey was carried out among crowdworkers from two crowdwork platforms – Figure Eight (microwork) and Upwork (online freelancing). Chi-square test was used to compare WLAs and SRL strategies among OFs and MWs.FindingsBoth groups use many WLAs and SRL strategies. Several significant differences were identified between the groups. In particular, moderate and moderately strong associations were uncovered, whereby OFs were more likely to report (i) undertaking free online courses/tutorials and (ii) learning by receiving feedback. In addition, significant but weak or very weak associations were identified, namely, OFs were more likely to learn by (i) collaborating with others, (ii) self-study of literature and (iii) making notes when learning. In contrast, MWs were more likely to write reflective notes on learning after the completion of work tasks, although this association was very weak.Originality/valueThe paper contributes empirical evidence in an under-researched area – workplace learning practices in crowdwork. Crowdwork is increasingly taken up across developed and developing countries. Therefore, it is important to understand the learning potential of this form of work and where the gaps and issues might be. Better understanding of crowdworkers’ learning practices could help platform providers and policymakers to shape the design of crowdwork in ways that could be beneficial to all stakeholders.
How would the managementof human behavior variables influence customer-oriented management?
Authors: Valenzuela-Fernández Leslier M. , Arroyo-Cañada Francisco-Javier , Villegas Pinuer Francisco Javier 
Published: June 2019

PurposeSalesperson’s actions are critical in helping the firm develop customer value orientation and long-term relationship with profitable customers to achieve sustainable sales growth and profitability over time. The purpose of this paper is to examine the salespeople and service executives’ perceptions about the relevance of some human resource management variables and employees’ attitudes as key factors to develop a company’s customer value orientation. The authors tested whether the perceptions of role ambiguity, incentives policy and provided training (PT) had an impact on job involvement (JI), job satisfaction (JS), and consequently, on customer value orientation.Design/methodology/approachResearch design was nested with data from 327 executives from medium and upper positions in Chilean companies.FindingsThe results show that while the perception of role ambiguity had an indirect negative impact on customer value orientation through JI, perception of PT level had a direct impact over and above the other variables.Research limitations/implicationsJS and JI are attitudinal variables, which companies try to encourage in their employees through different human resources, practices. Incentives and training are ways to develop favorable employees’ attitudes and improve their customer value orientation. With the research, companies could invest their resources in better and more effective practices to generate favorable attitudes toward customer value orientation.Originality/valueThrough structural equation modeling, the model shows the relevance in the perception of sales executives about the relationship of employees’ JI and customer value orientation. This commands to open the view of the customer value orientation management to include other attitudinal variables as JI.
The role of technocratic and socio-ideological controls in managing tensions when integrating international subsidiaries
Authors: Carlsson-Wall Martin , Hirner Peter , Kraus Kalle , von Lewinski Adrian 
Published: June 2019

Purpose
This paper aims to analyse how a multinational organisation uses technocratic and socio-ideological controls to manage tensions arising when integrating its international subsidiaries.

Design/methodology/approach
Through interviews and company documentation, the authors analyse how a global German family business firm integrates its international subsidiaries into the corporate context.

Findings
The findings suggest that technocratic and socio-ideological controls in combination help the firm manage three tensions – vertical vs lateral relations, standardisation vs differentiation of practices and centralisation vs decentralisation of decision-making – arising in the course of internationalisation. These results have important analytical implications for the understanding of how a high level of compliance to technocratic control initiatives is achieved. Prior work has, in the main, focussed on the resistance to technocratic controls without paying much attention to compliance. Specifically, the authors show how managers can use socio-ideological control to achieve a high level of compliance among employees when implementing technocratic controls.

Practical implications
The results suggest that managers in multinational firms need to pay careful attention to the tensions that are created when they internationalise and to apply a combination of technocratic and socio-ideological controls to manage these tensions.

Originality/value
There is limited knowledge of how managers use socio-ideological control to enact a particular form of experience for their employees and to create a highly valued sense of purpose. The findings suggest that these controls, in combination with technocratic ones, serve important roles when organisations expand internationally.