bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traffic Models for Energy Harvesting Based Wireless Sensor Networks
Authors: Kaur Pardeep , Singh Preeti , Sohi Balwinder S. 
Published: March 2019

Background:
Energy consumption is an important parameter in wireless sensor networks
since it affects the lifetime of sensor nodes.

Methods:
Battery powered wireless sensor networks cannot sustain for long hence impractical for
real-time applications. With energy harvesting and relevant protocols, this issue of extending the
lifetime of nodes has been solved largely. The performance can be enhanced further if proper traffic
analysis and modeling are done as a proactive approach.

Results:
A proper understanding of the traffic dynamics provides a base for further network optimization
and detection of anomalies within the network. Much of the reported work in energy harvesting
based WSN till now, is to design the efficient protocols only, traffic analysis and modeling is the
ignored parameter. In this paper traffic models appropriate for the energy harvesting based system
have been analyzed and their performance is evaluated for a MAC protocol.

Conclusion:
Results show that Weibull distribution is the most useful model for traffic modeling in
energy harvesting based wireless sensor networks.
Hexacyclododecylamines with Sigma-1 Receptor Affinity and Calcium Channel Modulating Ability
Authors: Joubert Jacques , Strydom Natasha , Geldenhuys Werner J. , Greyling Yolande , V. Dyk Sandra , Malan Sarel F. 
Published: March 2019

Introduction:
Recent research points to the Sigma Receptor (σR) as a possible neuromodulatory system with multi-functional action and σ1Rs have been suggested as a drug target for a number of CNS conditions. Hexacyclododecylamines have shown σ1R activity and provide an advantageous scaffold for drug design that can improve the blood-brain barrier permeability of privileged structures.

Methods and Materials:

A series of oxa- and aza- hexaxcyclododecylamines were synthesised and evaluated for sigma-1 receptor activity and voltage-gated calcium channel blocking ability to determine the effect of inclusion of amine containing heterocycles.

Results & Discussion:
The compounds had promising σ1R activities (Ki = 0.067 – 11.86 µM) with the aza-hexacyclododecylamines 12, 24 and 27 showing some of the highest affinities (Ki = 0.067 µM, 0.215 µM and 0.496 µM respectively). This confirms, as observed in previous studies, that the aza compounds are more favourable for σ1R binding than their oxa counterparts. The addition of the amine heterocycle showed affinities similar to that of related structures with only two lipophilic binding regions. This indicates that the inclusion of an amine heterocycle into these structures is a viable option in the design of new σ1R ligands. Significant voltage-gated calcium channel blocking ability was also observed for 12, 24 and 27, suggesting a link between σ1R activity and intracellular calcium levels.

Conclusion:
The σ1R activity and potential effect on other receptor classes and calcium channels could prove beneficial in pharmacological application.
Dentists and Dental Intern’s Preferences of Root Canal Treatment with Restoration Versus Extraction then Implant-Supported Crown Treatment Plan
Authors: Alwadani Mohammad , Mashyakhy Mohammed H. , Jali Amr , Hakami Arwa O. , Areshi Ahmed , Daghriri Abdlelah A. , Shaabi Fawzia I. , Al Moaleem Mohammed M. 
Published: March 2019

Objectives:
The intent of this study was to evaluate and compare the preferences and treatment choices between dentists and dental interns with regard to the following different treatment modalities: Root Canal Treatment (RCT) with restoration versus extraction with Implant-Supported Crown (ISC) or surgical treatment in relation to the given case scenarios.

Methods:
The questionnaire was presented as an online survey with a case scenario. The total number of the respondents were 165. The four clinical case scenarios included an anterior and posterior tooth having apical periodontitis, with and without previous RCT. The treatment options were as follows: RCT with restoration, extraction then implant, and surgical treatment.

Results:
A total of 165 dentists and dental interns were included in this study. A hundred and three 62.4% respondents were dentists, 60; 36.3% were males and 105; 63.7% were females. Most of the respondents graduated from the College of Dentistry, Jazan University (93.9%). The highest percentages and numbers for Anterior Teeth (AT) were selected in related to the RCT and restorations in the four scenarios among gender, dentists, and interns, with no considerable differences. A high percentage of RCT and restoration option was recorded for Posterior Teeth (PT) with no previous restoration and around 50% for the same treatment modality to posterior teeth with previous restorations. For Future Planning Postgraduate Studies (FPPS), it was obvious that most of the selected specialties agreed with the RCT and restorations choice.

Conclusion:
All dentists and interns in both genders preferred RCT with restorations over extraction, and then ISC in the AT with and without previous RCTs. In the PT with no previous RCT, the participants agreed that RCT with restorations is superior to other choices. Among the FPPS, the respondents demonstrated an absolute agreement to RCT and restorations as a treatment of choice for different scenarios.

Clinical Significance:
Dentists should preserve the natural teeth by RCT with restoration as the first treatment choice followed by other choices. The nonsurgical approach should always be adopted as a routine measure in PA lesions of endodontic origin. Conservative orthograde endodontic therapy demonstrates favorable outcomes with a regular periodic review and assessment of the healing process of PA lesions.
Social Media Utilization among Dental Practitioner in Riyadh, Saudi Arabia
Authors: Hamasha Abed A-H , Alghofaili Nasser , Obaid Abdulrahman , Alhamdan Mohammed , Alotaibi Abdulrahman , Aleissa Mohammed , Alenazi Menwer , Alshehri Faisal , Geevarghese Amritha 
Published: March 2019

Objective:To assess the dental practitioners' use of social media, concerning demographic and social variables and the impact of social media use on dental practice.Methods:The study was a cross-sectional analytical study of dental practitioners in Riyadh, Saudi Arabia. A self-administered 30-items questionnaire was distributed to 438 dentists, which included eight questions related to background and demographic information and 22 questions related to the use of social media within the dental practice. Data were entered and analyzed usingSPSSsoftware. Data analysis included frequency distributions and chi-square tests to assess the association of social media use with demographic and social variables and its impact on dental practice. Significant level was considered ifpwas less than 0.05.Results:Of participating, 338 dentists, 52% were using social media in their practice. Twitter was the most commonly used (35%). Education was the primary purpose of using social media (43%), while entertainment was the least (8%). Approximately 62% and 68% are using social media for marketing of their dental practice and broadcasting treatment outcome, respectively. Social media was observed to be used significantly higher among Non-Saudi, general and private dentists. Participating dentists who used social media in their practice significantly recommended using social media to other dentists.Conclusion:In general, non-Saudis, general practitioners and dentists practicing in private clinics are significantly using more social media during their practice. The majority of dental practitioners indicated that social media has improved their dental practice and become an indicator of successful practice.
Investigating the Efficiency of APRI, FIB-4, AAR and AARPRI as Noninvasive Markers for Predicting Hepatic Fibrosis in Chronic Hepatitis B Patients in Bangladesh
Authors: Sha Fazley R. , Pk Moyen Uddin , Abuelezz Nermeen Z. , Pervin Rumana , Talukder Rabiul I. , Begum Momtaj , Rahman Matiar 
Published: March 2019

Background and Aims:Accurate, affordable non-invasive markers are highly needed for efficient diagnosis and management of liver fibrosis caused by chronic hepatitis B. This is the first study to investigate the diagnostic efficiency of Aspartate Transaminase to Platelet Ratio (APRI), Fibrosis Index (FIB-4), Aspartate transaminase to Alanine Transaminase Ratio (AAR) and AAR/Platelet ratio index (AARPRI) as non-invasive markers to predict hepatic fibrosis caused by Chronic Hepatitis B (CHB) in Bangladesh.Methods:In this study, a training cohort of 1041 CHB patients were recruited, whereas 104 and 109 CHB patients of matched ages were recruited as internal and external validation cohort groups respectively. Histological and hematological data were analyzed. METAVIR scoring system was used to classify liver fibrosis stages. Area Under Receiver Operating Curve (AUROC), correlations and cutoff values for the four diagnostic markers were calculated and assessed.Results:92%, 81% and 84% of the patients had liver fibrosis in the training cohort, internal and external cohort groups respectively. Among the four noninvasive panels, APRI showed the best area under ROC; (0.767, CI: 0.780-0.914; 0.775) for the training cohort, (0.775, CI: 0.693-0.857), and (0.847, CI: 0.780-0.914) for the internal and external cohorts respectively. Cut-off value of APRI was 0.512 with sensitivity/specificity of 84%/67% in training cohort, 81% / 66% in the internal cohort, and 88% / 66% in an external cohort. The odds ratio for APRI was 32.95 (95%CI: 4.746-228.862,p<0.001).Conclusion:Among all the four tested markers, APRI is the most accurate non-invasive test to predict major liver fibrosis (F2-3) in Bangladeshi CHB patients.
Intrafamilial Diversity of Clinical Severity in Dominant Dystrophic Epidermolysis Bullosa: Case Series of Three Generations
Authors: Diana Inne Arline , Gondokaryono Srie Prihianti , Dwiyana Reiva Farah , Rahardja July Iriani , Yogya Yuri , Gunawan Hendra 
Published: March 2019

Background:
Epidermolysis bullosa, a group of inheritable blistering diseases with considerable clinical and genetic diversity, is divided into distinct subtypes depending on the level of tissue separation in the dermal–epidermal basement membrane zone. The dystrophic form of epidermolysis bullosa (DEB) is characterized by tense blisters and erosions which heals with extensive scarring. The fact that DEB can be inherited in either autosomal dominant (DDEB) or autosomal recessive (RDEB) pattern adds to its clinical diversity. The cause of marked clinical diversity in mild to severe DDEB is still unidentified.

Main Observation:
We report an intrafamilial diversity of clinical severity in dominant dystrophic epidermolysis bullosa (DDEB) cases within three generations.

Conclusion:
We emphasize the variety of clinical severity in DDEB cases within three generations which might be caused by unknown gene modifiers and environmental factors.
Bafilomycin-A1 and ML9 Exert Different Lysosomal Actions to Induce Cell Death
Authors: Shaikh Soni , Nandy Suman K , Cantí Carles , Lavandero Sergio 
Published: March 2019

Objective:Bafilomycin-A1 and ML9 are lysosomotropic agents, irrespective of cell types. However, the mechanisms of lysosome targeting either bafilomycin-A1 or ML9 are unclear.Methods:The present research has been carried out by different molecular and biochemical analyses like western blot, confocal imaging and FACS studies, as well as molecular docking.Results:Our data shows that pre-incubation of neonatal cardiomyocytes with ML9 for 4h induced cell death, whereas a longer period of time (24h) with bafilomycin-A1 was required to induce an equivalent effect. Neither changes in ROS nor ATP production is associated with such death mechanisms. Flow cytometry, LC3-II expression levels, and LC3-GFP puncta formation revealed a similar lysosomotropic effect for both compounds. We used a molecular docking approach, that predicts a stronger inhibitory activity against V-ATPase-C1 and C2 domains for bafilomycin-A1 in comparison to ML9.Conclusion:Bafilomycin-A1 and ML9 are lysosomotropic agents, involved in cell death events. But such death events are not associated with ATP and ROS production. Furthermore, both the drugs target lysosomes through different mechanisms. For the latter, cell death is likely due to lysosomal membrane permeabilization and release of lysosomal proteases into the cytosol.
Exploring the Type 2 Diabetes Management in the Primary Care Setting in Ratchaburi Province, Thailand
Authors: Khamthana Phenchamat , Meebunmak Yaowaluck , Siramaneerat Issara 
Published: March 2019

Purpose:We aimed to describe the outcomes of primary care setting of type 2 diabetes patient at Sub-District Health Promoting Hospital (SDHPH).Methods:This study was a cross-sectional study on 1,890 patients with type 2 diabetes who were participating in the primary care research networks in the Ratchaburi Province of Thailand. Data was obtained through a self-administered questionnaire about the state of health and care. Patient medical records were used to examine the condition of complications, treatment and several indicators of DM care. The data was processed by using logistic regression to analyse the effect of independent variables on the dependent variable. The hypothesis-null was rejected at p-values <0.05.Results:The participants in this study were of age 57.56 years (SD=12.10), and most (55.58%) were female. Most respondents (36.20%) completed a Bachelor’s degree and were working as employees (28.35%). Regarding duration of diabetes, the majority (28.35%) had 11-20 years. In terms of body mass index, 29.67% had body mass index between 25.0-29.9 (overweight). Regarding complications and comorbidities, the common complication and comorbidity was nephropathy (33.63%) while Ischemic heart disease was the major of other comorbid health problems (48.3%). Furthermore, patients were mostly taking Antihypertensive (67.80%) and ACE Inhibitor or ARB (59.00%). The majority of HbA1c level (42.74%) was lower than 7.0%. Regarding the logistic analysis, it showed that education and treatment significantly influenced Hemoglobin A1c level at significant levels of 0.05.Conclusion:Only modest numbers of patients achieved established targets of diabetes control. Reengineering primary care practice may be necessary to substantially improve health care.
Green Synthesis of Silver Nanostructures Using Aqueous Extract of Dracocephalum kotschyi and Evaluation of Antioxidant Properties of Herbal Extracts and Antibacterial Feature of Green- Synthesized Nanostructures
Authors: Goli Zahra , Izanloo Cobra 
Published: March 2019

Background:
Silver nanoparticles have a profound role in the field of high sensitivity
biomolecular detection, catalysis, biosensors and medicine. In the present study,
aqueous extract of Dracocephalum kotschyi has been used for the synthesis of silver
nanoparticles.

Objective:
In this study, we evaluated the antioxidant features and the possibility of biosynthesis
of AgNPs using an aqueous extract of Dracocephalum kotschyi and also evaluated the
antibacterial activities of the synthesized nanoparticles.

Methods:
An eco-friendly and cost-effective protocol for the synthesis of Ag nanoparticles by
utilizing a renewable natural resource, aqueous solution of Dracocephalum kotschyi, was
proposed. Synthesized nanoparticles were characterized by UV–Vis spectroscopy, SEM,
EDS, and XRD pattern.

Results:
At first, the extract of Dracocephalum kotschyi was assessed to determine and confirm
the presence of an antioxidant feature. Resuscitation of one mM silver nitrate solution
was carried out by the herbal extract. The solution containing AgNPs obtained from green
synthesis had a maximum optical density at 225 nm. In addition, the presence of AgNPs was
approved by energy-dispersive X-ray spectroscopy (EDS). Images of the scanning electron
microscope demonstrated that the synthesized AgNPs had the shape of rods and the size distribution
of 48-51 nm. One of the benefits of this method is a uniform size distribution.
Moreover, the effects of reaction time and concentration of the herbal extract were assessed
by ultraviolet-visible (UV-Vis) spectroscopy. In the end, we assessed the antibacterial impact
of the synthesized AgNPs against some pathogenic bacterial strains. According to the results,
the produced nanostructures had a proper impact on two bacteria of Escherichia coli and
Staphylococcus aureus.

Conclusion:
According to the results of the present study, Dracocephalum kotschyi can be a
suitable compound for the synthesis of nanostructures due to its indigenous cultivation and
great medicinal properties.
ANN-Based Relaying Algorithm for Protection of SVC- Compensated AC Transmission Line and Criticality Analysis of a Digital Relay
Authors: Fayaz Farhana , Pahuja Gobind Lal 
Published: March 2019

Background:The Static VAR Compensator (SVC) has the capability of improving reliability, operation and control of the transmission system thereby improving the dynamic performance of power system. SVC is a widely used shunt FACTS device, which is an important tool for the reactive power compensation in high voltage AC transmission systems. The transmission lines compensated with the SVC may experience faults and hence need a protection system against the damage caused by these faults as well as provide the uninterrupted supply of power.Methods:The research work reported in the paper is a successful attempt to reduce the time to detect faults on a SVC-compensated transmission line to less than quarter of a cycle. The relay algorithm involves two ANNs, one for detection and the other for classification of faults, including the identification of the faulted phase/phases. RMS (Root Mean Square) values of line voltages and ratios of sequence components of line currents are used as inputs to the ANNs. Extensive training and testing of the two ANNs have been carried out using the data generated by simulating an SVC-compensated transmission line in PSCAD at a signal sampling frequency of 1 kHz. Back-propagation method has been used for the training and testing. Also the criticality analysis of the existing relay and the modified relay has been done using three fault tree importance measures i.e., Fussell-Vesely (FV) Importance, Risk Achievement Worth (RAW) and Risk Reduction Worth (RRW).Results:It is found that the relay detects any type of fault occurring anywhere on the line with 100% accuracy within a short time of 4 ms. It also classifies the type of the fault and indicates the faulted phase or phases, as the case may be, with 100% accuracy within 15 ms, that is well before a circuit breaker can clear the fault. As demonstrated, fault detection and classification by the use of ANNs is reliable and accurate when a large data set is available for training. The results from the criticality analysis show that the criticality ranking varies in both the designs (existing relay and the existing modified relay) and the ranking of the improved measurement system in the modified relay changes from 2 to 4.Conclusion:A relaying algorithm is proposed for the protection of transmission line compensated with Static Var Compensator (SVC) and criticality ranking of different failure modes of a digital relay is carried out. The proposed scheme has significant advantages over more traditional relaying algorithms. It is suitable for high resistance faults and is not affected by the inception angle nor by the location of fault.
To Improve the Web Personalization Using the Boosted Random Forest for Web Information Extraction
Authors: Rao Pappu Srinivasa , Devara Vasumathi 
Published: March 2019

Background:
Web personalization is kind of method that is applied to modify a web site
to suit the exact needs of the users, achieving the advantage of data accomplished for the understanding
the directional conduct of users concerning inclusion of more materials in the web framework.

Methods:
In this paper an Finding Large Itemsets produce all blends of things that comprises of a
bolstering an incentive over a client illustrated least support. The total number of exchanges which
consists of the itemset is nothing but the support for an itemset. For the purpose of ranking the list,
the calculated values with the user ranked list are offered to the fuzzy-bat.

Results:
The result shows that the proposed methodology that perceives the challenge of mining affiliation
presides over in an organization of exchanges could be defined as the problem of producing
all the affiliation henceforth making a decision which would possess bolster esteem more significant
in comparison to a client that exemplified least support as well as certainty esteem more noteworthy
than a client characterized least certainty.

Conclusion:
This paper comprehensively describes the our proposed the preciseness of the system is
in contrast to a great extent with the present method for the varied questions that has been provided.
The computed esteems with the client positioned rundown are provided to the fluffy bat to rank the
rundown. The proposed technique has been compared with the prevailing fuzzy technique with regard
to the response time as well as the precision.
Factores relacionados con la seguridad y la calidad en la atención del paciente pediátrico hospitalizado
Authors: Barrientos Sánchez J. , Hernández Zavala M. , Zárate Grajales R.A. 
Published: March 2019

Introducción: La atención proporcionada a los usuarios de los sistemas de salud puede derivar con relativa frecuencia en un evento adverso (EA), debido a factores intrínsecos, extrínsecos o del sistema.
Objetivo: Analizar los factores relacionados con la calidad y la seguridad de los pacientes pediátricos hospitalizados, a través de los reportes de eventos adversos. Métodos: Estudio derivado de un proyecto multicéntrico, transversal, prospectivo. Unidad de observación: todos los eventos adversos reportados en niños hospitalizados de 0 a 18 años, en un Instituto Nacional de Salud de la Ciudad de México, de junio de 2014 a julio de 2015. Se utilizó el instrumento SYREC para el reporte. Análisis estadístico descriptivo y comparación de variables mediante Chi cuadrada y prueba exacta de Fisher.
Resultados: Se registraron 173 eventos adversos, 55% fueron del sexo masculino, mayor ocurrencia <1 año (43%), áreas críticas 60%. Principales eventos: extubaciones no programadas (16%), UPP (14%), flebitis (10%), lesiones (9%), quemaduras (8%) y medicamentos (6%). Los factores del sistema se presentaron en 39% (distracción, sobrecarga, falta de comunicación, falta de habilidad, supervisión). Factores extrínsecos 35% (acceso a la monitorización, manejo terapéutico). Factores intrínsecos 26% (condición clínica del paciente).
Conclusiones: La calidad y seguridad en la atención del paciente, se ve mermada principalmente por factores del sistema, esto debido a la amplia gama de funciones que debe realizar el profesional de enfermería, lo que conlleva a distracciones que diluyen el perfil de su rol y se apartan del objetivo principal que es el cuidado.