bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response
Authors: Zong Xin , Zhao Jing , Wang Hong , Lu Zeqing , Wang Fengqin , Du Huahua , Wang Yizhen 
Published: December 2018

Abstract
A better understanding of the molecular mechanism of intestinal fatty acid absorption could lead to novel approaches to treatment and prevention of fatty acid–related metabolic diseases. Although it is confirmed that absorption of long-chain fatty acids (LCFAs) decreases during the pathological processes, the genetic basis and molecular mechanisms remain largely unknown. N6-methyladenosine (m6A) is the most prevalent internal modification on eukaryotic mRNA. Recently, m6A has been found to play important roles in inflammation and antiviral responses. In this study, we show that deficiency of Mettl3, the core methyltransferase of m6A, exerts antimalabsorption of LCFA activity in vitro through inhibiting the inflammation response mediated by LPS. To substantiate this finding further, we found the levels of triglycerides were also sustained in cells with depleted Mettl3, which were cultured in Transwell to polarize with villus formation to simulate the situation in vivo. Mechanistically, depletion of Mettl3 decreases the m6A level of Traf6 mRNA, thereby its transcripts are entrapped in the nucleus, followed by the decreased expression of Traf6, leading to the suppression of NF-κB and MAPK signaling pathway. Thus, the inflammation response was suppressed, resulting in the sustained absorption of LCFA. Moreover, we found that ectopic expression of Traf6 largely abolishes the sustained absorption LCFA in Mettl3 depletion cells. Collectively, silencing Mettl3 could sustain LCFA absorption through blocking the TRAF6-dependent inflammation response. Our work uncovers a critical function of m6A methylation and provides insight into critical roles of Mettl3 in LCFA absorption and inflammatory disease.
Systematic Design of Ka-band Transmitter Modules using the M3-Approach
Authors: Ndip Ivan , Tschoban Christian , Reyes Jacob , Curran Brian , Lang Klaus-Dieter 
Published: December 2018

Abstract
In this work, we present and illustrate a holistic approach, the M3-approach (methodologies, models, measures), for efficient and accurate design of Ka-band transmitter modules in earth stations on mobile platforms (ESOMPs) for satellite communication applications. We begin by applying this approach to derive the system specifications, considering the application and international regulatory requirements. Based on these specifications, we derive the system/transmitter architecture, and then specify the components of this architecture. Furthermore, we develop a concept for low-cost realization of the transmitter module, and a concept for testing the module. For the implementation of the realization concept, 3D full-wave electromagnetic-based models are developed at the packaging and component levels. To verify these models, test samples are fabricated and measured. Excellent correlation is obtained between measurement and simulation results. The verified models are applied to optimize the RF performance of the Ka-band transmitter components and modules.
Advanced Build-up Materials for High Speed Transmission Application
Authors: Tatsumi Shiro , Fujishima Shohei , Sakauchi Hiroyuki 
Published: December 2018

Abstract
Build-up process is a highly effective method for miniaturization and high density integration of printed circuit boards. Along with increasing demands for high transmission speed of electronic devices with high functionality, packaging substrates installed with semiconductors in such devices are strongly required to reduce the transmission loss. Our insulation materials are used in a semi-additive process (SAP) with low dielectric loss tangent, smooth resin surface after desmear, and good insulation reliability. Actually, the transmission loss of strip line substrates and Cu surface roughness impact on transmission loss were measured using our materials. Furthermore, low dielectric molding film with low coefficient of thermal expansion (CTE) and low Young's modulus are introduced.
Low-fire Processing and Dielectric Properties of a Binary Crystallizable Glasses+alumina System
Authors: Tung Shih-An , Jean Jau-Ho 
Published: December 2018

AbstractCrystallization kinetics and dielectric properties of a low-temperature, cofirable binary crystallizable glasses (CaO-Al2O3-SiO2 (CAS) and CaO-B2O3-SiO2 (CBS)) with alumina have been investigated. With alumina present, the bloating is minimized and wollastonite formed in the binary crystallizable glasses is replaced by anorthite. With increasing amount of anorthite formed in the ternary alumina+CAS glass+CBS glass dielectric composite, the dielectric constant remains relatively unchanged but the dielectric loss decreases as sintering is extended.
Zinc Oxide Nanowire Sensor Packaging
Authors: Kim Bruce , Cho Sang-Bock 
Published: December 2018

Abstract
This paper describes nano device packaging topology using array of ZnO nanowire-based devices. The single nanowire device has been fabricated through focused ion beam and e-beam lithography techniques while the SEM and EDAX analysis have been used to characterize the device. The IV characteristics of the ZnO nanowire-based array devices have been measured through a semiconductor parameter analyzer.
When Failure is not an Option – Packaging Materials and Technologies for the Reliable Protection of Medical Electronics
Authors: Zetterer Th. , Herzberg J. , Baehr J. , Waxman K. 
Published: December 2018

Abstract
Enabling high-level electrical performance and smooth optical signal transmission is a key requirement for microelectronics packaging materials. This becomes even more relevant for biomedical applications, in which protection requirements must be met alongside standard performance and signal transmission benchmarks. The major challenge: medical packaging must to provide absolute reliability. Microelectronic components face potentially damaging working environment hazards such as high humidity, extreme temperatures, corrosive chemicals, and bodily fluid – especially in the application cases of implantable, ingestible, and wearable devices.
Hermeticity is an important factor in the performance of medical packaging. Non-hermetic packaging, sometimes known as “quasi-hermetic” uses organic materials, such as silicone or plastic over-moldings, that are not designed to withstand extreme conditions and break down over time. Material break down in these types of packages can lead to limited protection by allowing permeation of water and other gases through the polymer structure. Non-hermetic packages typically reach critical permeation levels after a very short period of time. For microelectronic components, even the smallest, hardly detectable traces of hydrogen and water vapor inside a package can compromise the performance and reliability of the encapsulated chips and circuits and potentially lead to interconnect failure, one of the most common reliability failure modes in microelectronic applications.
The only way to overcome the challenge of achieving absolute reliability is by using hermetic packaging technologies with inorganic materials, such as glass, ceramics and metal. Unique manufacturing processes of these hermetic components create vacuum-tight seals that prevent moisture and harmful gases from penetrating into the package. Hermetically sealed packages deliver uncompromised reliability, offering long-term protection of sensitive electronics in medical devices – even after thousands of surgical procedures and steam sterilization cycles.
This technical presentation will introduce the different reliability levels of packaging materials and provide an in-depth comparison of the respective advantages, disadvantages, and typical application areas of various hermetic packaging technologies. The latest insights into materials and technologies available for high-reliability packaging of medical electronics will be presented.
Growth of Intermetallics at Coated Silver Wire Bond Interfaces
Authors: Murali Sarangapani , Jason Wong Chin Yeung 
Published: December 2018

Abstract
The newly developed gold (Au) coated silver (Ag) wire exhibits axi-symmetrical free air ball (FAB) formation under atmosphere similar to Au wire. FAB of coated Ag showed better corrosion resistance than FAB of alloyed Ag, as Au dissolved along the periphery of Ag FAB forming into a solid-solution, Ag-Au alloy. Composition of the solid-solution Ag-Au alloy along the periphery ranges between 10 and 28wt% of Au. The diffusion depth of Au is 4μm from surface towards the center of FAB. For precise measurement of the diffusion length of Au into Ag, a solid thin layer is been parted using focus-ion beam (FIB). The solid thin layer is further thinned down to observe in Transmission Electron Microscope (TEM) and analyzed using line scan energy dispersive X-ray analysis (EDX) attached to it. Near the neck of FAB and wire, Au diffusion is high up to 58wt%. On thermal ageing at 150/175°C for 500/1000h, the coated Ag wire bonded to Al-0.5wt%Cu pad revealed no degradation on ball pull/shear. Bond interface revealed significant growth of silver aluminide (AgAl) to a thickness of 3μm for 1000h of ageing and the growth rate fits to square-root power law.
Glass Packaging for RF MEMS
Authors: Parmar Rajiv , Zhang Jay , Keimel Chris 
Published: December 2018

Abstract
In recent years, advancements in High Performance Computing and Photonics are driving towards high density semiconductor packaging requirements that are creating a need for the adoption of novel material sets. Glass has many attractive properties that help address product level challenges such as low height, and smaller, packages. Glass also offers high resistivity, low dielectric constant, adjustable coefficient of thermal expansion (CTE), and low electrical loss. These properties can also be leveraged for RF and Mobile applications where battery life is paramount. To further utilize glass' material properties for interposers and compact substrates, it is necessary to form precision or Through Glass Vias (TGVs). Mobile cellular networks are rapidly evolving towards fifth generation (5G), which is set to exploit a wider spectrum of frequencies that range into millimeter wave (mmWave). RF MEMS technology is a promising approach to addressing RF Switches, which are key building blocks into Radio Frequency Front Ends (RFFE). In this paper, we show the usage of glass based packaging solutions and TGVs to offer low form factor, broadband RF MEMS switches.
THE IMPACT OF GLASS STYLE AND ORIENTATION ON THE RELIABILITY OF SMT COMPONENTS
Authors: Serebrini Maxim , Caswell Greg 
Published: December 2018

Abstract
Printed circuit board (PCB) glass style and orientation can have a significant influence on thermal cycling reliability of surface mounted components. DfR has conducted thermal cycling (−40°C to 125°C) tests on two PCB glass styles (1080 and 7628). The in plane and out of plane Coefficients of Thermal Expansion (CTE) were measured and found to be about 3–4ppm/°C different in the X-Y directions of the boards. To facilitate the reliability assessment of SMT component reliability four 0-ohm resistor sizes (2512, 1206, 0602 and 0402) were mounted on each board. Each board had 20 resistors with multiple orientations. The overall sample size consisted of 32 resistors of each size per glass style. In addition, the PCBs have two pad sizes. The purpose of these experiments was to develop a model for validating fatigue life predictions for different laminate materials. This paper will present the experimental structure, results of the stress tests and variables on the reliability of the chip components and insight into the development of appropriate models.
Estimating radar precipitation in cold climates: the role of air temperature within a non-parametric framework
Authors: Sivasubramaniam Kuganesan , Sharma Ashish , Alfredsen Knut 
Published: December 2018

Abstract. The use of ground-based precipitation measurements in radar precipitation
estimation is well known in radar hydrology. However, the approach of using
gauged precipitation and near-surface air temperature observations to improve
radar precipitation estimates in cold climates is much less common. In cold
climates, precipitation is in the form of snow, rain or a mixture of the
two phases. Air temperature is intrinsic to the phase of the precipitation
and could therefore be a possible covariate in the models used to ascertain
radar precipitation estimates. In the present study, we investigate the use
of air temperature within a non-parametric predictive framework to improve
radar precipitation estimation for cold climates. A non-parametric predictive
model is constructed with radar precipitation rate and air temperature as
predictor variables and gauge precipitation as an observed response using a
k nearest neighbour (k-nn) regression estimator. The relative importance
of the two predictors is ascertained using an information theory-based
weighting. Four years (2011–2015) of hourly radar precipitation rates from
the Norwegian national radar network over the Oslo region, hourly gauged
precipitation from 68 gauges and gridded observational air temperatures were
used to formulate the predictive model, hence making our investigation
possible. Gauged precipitation data were corrected for wind-induced
under-catch before using them as true observed response. The predictive model
with air temperature as an added covariate reduces root-mean-square
error (RMSE) by up to 15 % compared to the model that uses radar
precipitation rate as the sole predictor. More than 80 % of gauge locations
in the study area showed improvement with the new method. Further, the
associated impact of air temperature became insignificant at more than 85 %
of gauge locations when the near-surface air temperature was warmer than
10 ∘C, which indicates that the partial dependence of precipitation
on air temperature is most useful for colder temperatures.
Instances of Agency: Julio Cordero’s Archive and Photographic Portraits
Authors: Coronado Jorge 
Published: December 2018

In this article, I discuss the notion of agency in relationship to Julio Cordero’s photographs. Julio Cordero (1879-1961) owned a photography studio in La Paz in the first half of the twentieth century and produced an array of images both inside and outside of the studio. I also offer a sense of the rich documentation that exists in the complete Cordero archive as well as the insights that it opens up concerning the interventions in self-representation made possible by photographic portraiture. Essentially, these interventions lead us to conceptualize image culture as a prime space for enacting agency in Bolivia and Latin American more broadly.
Contrebia Carbica. Estudio del sistema defensivo para un debate sobre poliorcética y urbanismo en la "Celtiberia" de los siglos II y I A.C.
Authors: Romeo Marugán Francisco 
Published: December 2018

Analizamos el sistema defensivo de Contrebia Carbica mediante la fotografía aérea histórica. Los resultados de este análisis serán la base para reflexionar sobre la aparición en Celtiberia de ciudades con rasgos similares durante el siglo II a.C. Se trata de un fenómeno que relacionamos con la influencia itálica en esta zona, proponiendo la Paz de Graco como detonante de una transformación radical e irreversible de la cultura indígena que acabara transformando su urbanismo, y por tanto su forma de vida, en la segunda mitad del siglo II a.C.
La competitividad geoestratégica Irán-Arabia Saudí en Oriente Medio. Rivalidad entre potencias regionales
Authors: González del Miño Paloma 
Published: December 2018

Irán y Arabia Saudí vienen destinando recursos económicos, políticos y culturales para lograr una posición hegemónica en Oriente Medio, a través de actuaciones directas o mediante actores interpuestos. Las primaveras árabes abrieron nuevas oportunidades para estos dos actores regionales que aprovechan escenarios inestables para ensanchar sus zonas de influencia. Con independencia de los conflictos bélicos (Siria, Líbano, Yemen, Irak y DAESH), lo que está en juego es la jerarquización de las relaciones de vecindad, las cuotas de influencia y poder y, por ende, el liderazgo regional. En esta lógica, sus políticas exteriores se han vuelto más pro-activas. Este artículo analiza las relaciones entre Irán y Arabia Saudí en su pivot area.
Escenarios del vacío y la desaparición. Ausencia y representación en Eco (Xacio Baño, 2015)
Authors: Redondo Neira Fernando 
Published: December 2018

Resumen Integrado en el movimiento del Novo Cinema Galego, decuyo carácter fronterizo participa, el filme Eco constituyeuna representación a la vez emotiva y reflexiva sobre las ideas de vacío, ausencia y desaparición. La lectura en pantalla delos diarios de la madre de uno de los protagonistas sitúa estamuestra de no ficción en una de las líneas más innovadorasdel cine contemporáneo: la expresión de la subjetividady la proyección exterior de determinados aspectos de laintimidad. El análisis fílmico procura comprender cómo las imágenes logran, con la concreción que les caracteriza y unasobriedad formal extrema, abordar la abstracción propia de las emociones. Resumo Integrado no movimento do Novo Cinema Galego, decujo carácter fronteiriço participa, o filme Eco constituiao mesmo tempo uma representação emotiva e reflexivasobre as ideias do vácuo, ausência e desaparecimento.A leitura em écran dos diários da mãe de um dosprotagonistas coloca esta amostra de não ficção numa das linhas mais inovadoras do cinema contemporâneo:a expressão da subjectividade e a projeção exterior de determinados aspectos da intimidade. A análise fílmicatenta compreender como as imagens conseguem, com aconcretude que lhes caracteriza e uma sobriedade formalextrema, tratar da abstração própria das emoções. AbstractIntegrated into the movement of Novo Cinema Galego and taking part of its borderline characteristic, the filmEco constitutes an emotional and reflective representationof the concepts of emptiness, absence and disappearance.The reading on the screen of the mother’s diaries of one of the protagonists places this non-fiction sample as oneof the most innovative strands of contemporary cinema: the expression of subjectivity and the external projectionof certain aspects of intimacy. The film analysis tries tounderstand how images manage to, with the precision that characterizes them and an extreme formal sobriety, dealwith the abstraction typical of emotions.
Estructura y resiliencia social en comunidades indígenas: el caso de la Unión de Palmeadoras de Tlaxiaco, Oaxaca, México
Authors: Vázquez García Verónica , Nuñez Espinoza Juan Felipe , Ortega Ortega Tomás 
Published: December 2018

Las capacidades de resiliencia de comunidades indígenas pueden ser verificadas a través de su análisis como sistemas meso reticulares, abordando la fortaleza de sus estructuras en red endógenas y exógenas. El presente artículo analiza, desde el enfoque de redes sociales, el proceso de consolidación y persistencia organizativa de la Unión de Palmeadoras, integrada por mujeres mixtecas que se dedican a la elaboración y venta de tortillas artesanales. Las preguntas a responder, fueron: ¿cuál es la estructura social que dinamiza a la Unión de Palmeadoras de Tlaxiaco? ¿Para qué les ha servido formar parte de la unión? ¿Cuáles son las capacidades de resiliencia de la unión, considerando dicha estructura social? Los datos se obtuvieron en 2015 mediante un cuestionario aplicado a las 89 mujeres que integran la Unión. Los resultados muestran que la Unión de Palmeadoras es una estructura social con determinadas capacidades de resiliencia, derivadas de los procesos de cohesión, inclusión y competencia generados en su interior, pero también, una organización sumamente frágil debido a procesos endógenos y exógenos de su entorno local y regional.
Growth perspectives for the Europe’s shipbuilding industry in the context of world economy trends and competition from Asian shipyards’
Authors: Kowalczyk Urszula 
Published: December 2018

This paper aims at analyzing the Polish as well as the European commercial shipbuilding industry in the context of Asian shipyards competition, particularly its growth, trend, and future forecast. Shipbuilding growth has been analyzed	based on data concerning the shipbuilding market segment, order book, countries share, government’s policies etc.
The first part contains a brief analysis of main trends in the world shipbuilding that have an impact on the shipbuilding environment in Europe. The second part highlights European aspects of shipbuilding in the context of Asian shipbuilders domination. The key factors that drive the growth of the shipbuilding market have also been considered. The third part examine the prerequisites of shipbuilding sector future development in the Baltic Sea basin and in particular in Poland.
It is revealed that the shipbuilding industry in Poland and the Baltic Sea basin has limited opportunities for significant expansion. Most formerly renown shipyards based its current activity on supplying hulls and blocks to main producers of passenger ships or offshore units. As a highly capital-intensive industry, the shipbuilding sector needs strong government support and political stability in order to remain on the market and tackle the competition of Asian shipbuilding giants.