bluuebunny/crossref_metadata_2025_split huggingface dataset:
Employee’s green behavior for environmental sustainability: a case of banking sector in Pakistan
Authors: Iqbal Qaisar , Hassan Siti Hasnah , Akhtar Sohail , Khan Shahid 
Published: February 2018

Purpose
The purpose of this paper is to find out the relationship between employee’s green behaviors (EGBs) and environmental sustainability (ES). Presently, many ES issues have impact on organizations, e.g., energy cost and climate change. In business world, there is a positive trend among organizations to start reporting over performance of ES keeping their role as corporate social responsibility alive.

Design/methodology/approach
Self-administered questionnaires were floated to gather data from employees of manufacturing and service industry. In order to analyze the collected data, regression analysis and correlation coefficient were employed to check hypotheses. Statistical Package of Social Sciences has been used for data analysis.

Findings
Results reveal that there is a direct positive relationship between EGB and environment sustainability. The five dimensions of EGB, i.e., working sustainability, conserving, avoiding harm, influencing others and taking initiative also have significant association with ES. ES carries with itself sensational openings for the HRM role and with the opportunity originates responsibility.

Practical implications
This study emphasizes the revised planning of training and development programs to create awareness among employees and strategies to improve ES and corporate social responsible level of organizations in competitive world.

Originality/value
This research carries a new horizon to explore the association of EGBs with ES in banking sector. The study presents first-ever empirical evidence about the relationship between ES and EGBs from developing countries.
Characterization of morphological conversion of Helicobacter pylori under anaerobic conditions
Authors: Hirukawa Sayaka , Sagara Hiroshi , Kaneto Satoshi , Kondo Tomoyo , Kiga Kotaro , Sanada Takahito , Kiyono Hiroshi , Mimuro Hitomi 
Published: February 2018

ABSTRACTHelicobacter pylori (H. pylori), a gram‐negative microaerophilic bacterial pathogen that colonizes the stomachs of more than half of all humans, is linked to chronic gastritis, peptic ulcers and gastric cancer. Spiral‐shaped H. pylori undergo morphologic conversion to a viable but not culturable coccoid form when they transit from the microaerobic stomach into the anaerobic intestinal tract. However, little is known about the morphological and pathogenic characteristics of H. pylori under prolonged anaerobic conditions. In this study, scanning electron microscopy was used to document anaerobiosis‐induced morphological changes of H. pylori, from helical to coccoid to a newly defined fragmented form. Western blot analysis indicated that all three forms express certain pathogenic proteins, including the bacterial cytotoxin‐associated gene A (CagA), components of the cag‐Type IV secretion system (TFSS), the blood group antigen‐binding adhesin BabA, and UreA (an apoenzyme of urease), almost equally. Similar urease activities were also detected in all three forms of H. pylori. However, in contrast to the helical form, bacterial motility and TFSS activity were found to have been abrogated in the anaerobiosis‐induced coccoid and fragmented forms of H. pylori. Notably, it was demonstrated that some of the anaerobiosis‐induced fragmented state cells could be converted to proliferation‐competent helical bacteria in vitro. These results indicate that prolonged exposure to the anaerobic intestine may not eliminate the potential for H. pylori to revert to the helical pathogenic state.
Glycosylation on proteins of the intestine and perimicrovillar membrane of Triatoma (Meccus) pallidipennis, under different feeding conditions
Authors: Gutiérrez‐Cabrera Ana E. , Zandberg Wesley F. , Zenteno Edgar , Rodríguez Mario H. , Espinoza Bertha , Lowenberger Carl 
Published: February 2018

AbstractTrypanosoma cruzi, the causative agent of Chagas disease, interacts with molecules in the midgut of its insect vector to multiply and reach the infective stage. Many studies suggest that the parasite binds to midgut‐specific glycans. We identified several glycoproteins expressed in the intestine and perimicrovillar membrane (PMM) of Triatoma (Meccus) pallidipennis under different feeding conditions. In order to assess changes in protein‐linked glycans, we performed lectin and immunoblot analyses on glycoprotein extracts from these intestinal tissues using well‐characterized lectins, and an antibody, which collectively recognize a wide range of different glycans epitopes. We observed that the amount and composition of proteins and glycoproteins associated with different glycans structures changed over time in the intestines and PMM under different physiological conditions. PMM extracts contained a wide variety of glycoproteins with different sugar residues, including abundant high‐mannose and complex sialylated glycans. We propose that these molecules could be involved in the process of parasite–vector interactions.
Effect of adding midazolam to bupivacaine during rectus sheath block: a randomised controlled trial
Authors: Ammar A. , Mahmoud K. , Kasemy Z. 
Published: February 2018

BackgroundVarious adjuvants have been tried to improve quality and increase duration of local anaesthetics during various nerve blocks. We aimed to evaluate the effect of adding midazolam to bupivacaine on rectus sheath (RS) block in patients undergoing umbilical or epigastric hernia repair.MethodsIn all, 60 adult patients were divided into two equal groups, each group included 30 patients. Group I received 20 ml of bupivacaine hydrochloride 0.25% + midazolam 50 μg/kg in 2 ml saline 0.9% (Midazolam group, n = 30), whereas Group II received 20 ml of bupivacaine hydrochloride 0.25% + 2 ml saline (Control group, n = 30) for RS block on each side. The primary outcome was post‐operative 48 h morphine consumption, whereas secondary outcomes included analgesia duration, post‐operative pain, as evaluated by visual analogue scale (VAS) for pain scoring at 1, 2, 6, 12, 24 and 48 h post‐operatively, reported post‐operative nausea and or vomiting (PONV), somnolence or any adverse drug reactions.ResultsThe current study showed that addition of midazolam to bupivacaine for RS blockade provided good analgesia as evidenced by a statistically significant less morphine consumption in the post‐operative 48 h [11.2 (5.3–18.3) vs. 25.9 (15.2–31.0) mg, P = 0.002], longer duration of analgesia, lower VAS during post‐operative 48 h, lower incidence of PONV, somnolence and pruritus.ConclusionMidazolam addition to bupivacaine for RS blockade provided adjuvant analgesia as supported by less morphine consumption, longer duration of analgesia, and lower VAS score.
The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway
Authors: Warnier Marine , Flaman Jean‐Michel , Chouabe Christophe , Wiel Clotilde , Gras Baptiste , Griveau Audrey , Blanc Elena , Foy Jean‐Philippe , Mathot Pauline , Saintigny Pierre , Van Coppenolle Fabien , Vindrieux David , Martin Nadine , Bernard David 
Published: February 2018

SummaryOncogenic signals lead to premature senescence in normal human cells causing a proliferation arrest and the elimination of these defective cells by immune cells. Oncogene‐induced senescence (OIS) prevents aberrant cell division and tumor initiation. In order to identify new regulators of OIS, we performed a loss‐of‐function genetic screen and identified that the loss of SCN9A allowed cells to escape from OIS. The expression of this sodium channel increased in senescent cells during OIS. This upregulation was mediated by NF‐κB transcription factors, which are well‐known regulators of senescence. Importantly, the induction of SCN9A by an oncogenic signal or by p53 activation led to plasma membrane depolarization, which in turn, was able to induce premature senescence. Computational and experimental analyses revealed that SCN9A and plasma membrane depolarization mediated the repression of mitotic genes through a calcium/Rb/E2F pathway to promote senescence. Taken together, our work delineates a new pathway, which involves the NF‐κB transcription factor, SCN9A expression, plasma membrane depolarization, increased calcium, the Rb/E2F pathway and mitotic gene repression in the regulation of senescence. This work thus provides new insight into the involvement of ion channels and plasma membrane potential in the control of senescence.
CRISPR/Cas9‐mediated MSTN disruption and heritable mutagenesis in goats causes increased body mass
Authors: Wang X. , Niu Y. , Zhou J. , Zhu H. , Ma B. , Yu H. , Yan H. , Hua J. , Huang X. , Qu L. , Chen Y. 
Published: February 2018

SummaryGenetic engineering in livestock has been greatly enhanced through the use of artificial programmed nucleases such as the recently emerged clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated 9 (Cas9) system. We recently reported our successful application of the CRISPR/Cas9 system to engineer the goat genome through micro‐injection of Cas9 mRNA and sgRNAs targeting MSTN and FGF5 in goat embryos. The phenotypes induced by edited loss‐of‐function mutations of MSTN remain to be evaluated extensively. We demonstrate the utility of this approach by disrupting MSTN, resulting in enhanced body weight and larger muscle fiber size in Cas9‐mediated gene‐modified goats. The effects of genome modifications were further characterized by H&E staining, quantitative PCR, Western blotting and immunofluorescence staining. Morphological and genetic analyses indicated the occurrence of phenotypic and genotypic modifications. We further provide sufficient evidence, including breeding data, to demonstrate the transmission of the knockout alleles through the germline. By phenotypic and genotypic characterization, we demonstrated the merit of using the CRISPR/Cas9 approach for establishing genetically modified livestock with an enhanced production trait.
Institutional Ownership and Stock Liquidity: International Evidence
Authors: Dang Tung Lam , Nguyen Thanh Huong , Tran Nguyen Tram Anh , Vo Thi Thuy Anh 
Published: February 2018

AbstractThis paper investigates the relation between institutional ownership and stock liquidity, and explores whether this relation differs across institutional settings. Using a comprehensive data set across 41 countries from 2000 to 2010, we find that institutional ownership is positively correlated with stock liquidity. Importantly, the positive association between institutional ownership and stock liquidity is stronger (weaker) for firms in countries with opaque (transparent) information environments or poor (good) institutional characteristics. Our additional analysis reveals that the positive association between institutional ownership and liquidity is attributable to non‐block institutional investors.
Oxygen concentration modulates cellular senescence and autophagy in human trophoblast cells
Authors: Seno Kotomi , Tanikawa Nao , Takahashi Hironori , Ohkuchi Akihide , Suzuki Hirotada , Matsubara Shigeki , Iwata Hisataka , Kuwayama Takehito , Shirasuna Koumei 
Published: February 2018

ProblemWe investigated the effect of oxygen concentrations on cellular senescence and autophagy and examined the role of autophagy in human trophoblast cells.Method of studyHuman first‐trimester trophoblast cells (Sw.71) were incubated under 21%, 5%, or 1% O2 concentrations for 24 hours. We examined the extent of senescence caused using senescence‐associated β‐galactosidase (SA‐β‐Gal) and senescence‐associated secretory phenotype (SASP) as markers. Moreover, we examined the role of autophagy in causing cellular senescence using an autophagy inhibitor (3‐methyladenine, 3MA).ResultsPhysiological normoxia (5% O2) decreased SA‐β‐Gal‐positive cells and SASP including interleukin‐6 (IL‐6) and IL‐8 compared with cultured cells in 21% O2. Pathophysiological hypoxia (1% O2) caused cytotoxicity, including extracellular release of ATP and lactate dehydrogenase, and decreased senescence phenotypes. 3MA‐treated trophoblast cells significantly suppressed senescence markers (SA‐β‐Gal‐positive cells and SASP secretion) in O2‐independent manner.ConclusionWe conclude that O2 concentration modulates cellular senescence phenotypes regulating autophagy in the human trophoblast cells. Moreover, inhibiting autophagy suppresses cellular senescence, suggesting that autophagy contributes to oxygen stress‐induced cellular senescence.
How do Small Groups Promote Behaviour Change? An Integrative Conceptual Review of Explanatory Mechanisms
Authors: Borek Aleksandra J. , Abraham Charles 
Published: February 2018

BackgroundSmall groups are used to promote health, well‐being, and personal change by altering members’ perceptions, beliefs, expectations, and behaviour patterns. An extensive cross‐disciplinary literature has articulated and tested theories explaining how such groups develop, function, and facilitate change. Yet these theoretical understandings are rarely applied in the development, description, and evaluation of health‐promotion, group‐based, behaviour‐change interventions.MethodsMedline database, library catalogues, search engines, specific journals and reference lists were searched for relevant texts. Texts were reviewed for explanatory concepts or theories describing change processes in groups, which were integrated into the developing conceptual structure. This was designed to be a parsimonious conceptual framework that could be applied to design and delivery.ResultsFive categories of interacting processes and concepts were identified and defined: (1) group development processes, (2) dynamic group processes, (3) social change processes, (4) personal change processes, and (5) group design and operating parameters. Each of these categories encompasses a variety of theorised mechanisms explaining individual change in small groups.ConclusionThe final conceptual model, together with the design issues and practical recommendations derived from it, provides a practical basis for linking research and theory explaining group functioning to optimal design of group‐based, behaviour‐change interventions.
Editorial: are additional tests needed to predict sustained virologic response in hepatitis C treated with interferon‐free direct‐acting antiviral combinations?
Authors: Ferenci P. 
Published: February 2018

Linked contentThis article is linked to Fourati et al and Fourati and Pawlotsky papers. To view these articles visit https://doi.org/10.1111/apt.14478 and https://doi.org/10.1111/apt.14520.
Safety, efficacy and pharmacokinetics of vedolizumab in patients with simultaneous exposure to an anti‐tumour necrosis factor
Authors: Ben‐Horin S. , Ungar B. , Kopylov U. , Lahat A. , Yavzori M. , Fudim E. , Picard O. , Peled Y. , Eliakim R. , Del Tedesco E. , Paul S. , Roblin X. 
Published: February 2018

SummaryBackgroundData on combination‐biologic treatment in (IBD) are still scant.AimTo explore outcomes of patients co‐exposed to anti‐TNF and vedolizumab.MethodsPatients starting vedolizumab having measurable anti‐TNF levels after recently stopping adalimumab/infliximab (‘VDZ‐aTNF’ group), were compared with control vedolizumab patients in a retrospective 1:2 matched case‐control study.ResultsSeventy‐five patients were included (25 VDZ‐aTNF, 50 VDZ). Adverse events were experienced by 9/25 VDZ‐aTNF compared to 13/50 VDZ patients (P = 0.4, follow‐up 14 weeks in all). Week 14 clinical remission was attained in 10/25 (40%) of VDZ‐aTNF patients versus 23/50 (46%) of VDZ patients (OR = 0.8, 95% CI 0.3‐2.1, P = 0.6) and clinical response in 19/25 (76%) versus 39/50 (78%) respectively (OR = 0.9, 95% CI 0.3‐2.7, P = 0.8). Corticosteroid‐free remission and corticosteroid‐free response were experienced by 30% and 54%, respectively, of the entire cohort, and were similar between the two groups. Vedolizumab drug concentrations at week 2, 6 and 14 were similar among VDZ‐aTNF and VDZ patients (P > 0.5). Multi‐variable analysis showed independent association of some vedolizumab drug‐levels time‐points with baseline albumin and weight, but not with anti‐TNF co‐exposure. In a prospective study of a separate cohort of patients starting infliximab (n = 12), the percentage of α4β7+ memory T cells, slightly but nonsignificantly increased throughout weeks 0, 2 to 14 (26 ± 2.3%, 27.8 ± 2.9%, 29.5 ± 2.6% respectively, P = 0.06).ConclusionsVedolizumab/anti‐TNF co‐exposure did not generate new safety signals during 14‐weeks induction, nor did it reduce efficacy or alter vedolizumab pharmacokinetics. These observations may aid the design of future co‐biologics trials and also suggest that a deliberate waiting‐interval between anti‐TNF cessation and subsequent vedolizumab initiation may not be warranted.
Developmental staging table of the green iguana
Authors: Lima Fabiano C. , Py‐Daniel Tainã R. , Sartori Marina R. , Abe Augusto S. , Santos Odeony Paulo dos , Freitas Letícia M. , Pereira Kleber F. , Sebben Antonio 
Published: February 2018

AbstractEmbryonic staging tables provide information to standardize embryological investigations and to subsidize discussions about evolution. We have established a developmental staging table for Iguana iguana iguana. The sample was composed of 142 embryos, incubated at a constant temperature and collected at regular intervals. Morphological features as pharyngeal arches, craniofacial structures, eyes, limbs, claws, pigmentation, scales and egg tooth were evaluated to determine development stages. The normal staging table includes 17 stages from oviposition to hatching, based on chronology and morphological external features. Stages from 1 to 27 occur before oviposition. Stage 28 was the first described, because all embryos presented limb bud anlage, key feature of the previous stage. We used pharyngeal arches and limb buds to describe the first stages; claws, genital papilla and scales to describe the middle stages; and pigmentation, size and egg tooth to describe the last stages. Incubation lasted approximately 2 months in a controlled environment. The results were similar to the data from other lizards, confirming the embryonic conservative pattern of the group.
The Institution of Sociological Theory in Canada
Authors: Guzman Cinthya , Silver Daniel 
Published: February 2018

AbstractUsing theory syllabi and departmental data collected for three academic years, this paper investigates the institutional practice of theory in sociology departments across Canada. In particular, it examines the position of theory within the sociological curriculum, and how this varies among universities. Taken together, our analyses indicate that theory remains deeply institutionalized at the core of sociological education and Canadian sociologists’ self‐understanding; that theorists as a whole show some coherence in how they define themselves, but differ in various ways, especially along lines of region, intellectual background, and gender; that despite these differences, the classical versus contemporary heuristic largely cuts across these divides, as does the strongly ingrained position of a small group of European authors as classics of the discipline as a whole. Nevertheless, who is a classic remains an unsettled question, alternatives to the “classical versus contemporary” heuristic do exist, and theorists’ syllabi reveal diverse “others” as potential candidates. Our findings show that the field of sociology is neither marked by universal agreement nor by absolute division when it comes to its theoretical underpinnings. To the extent that they reveal a unified field, the findings suggest that unity lies more in a distinctive form than in a distinctive content, which defines the space and structure of the field of sociology.
Clinical parameters of ovarian hyperstimulation syndrome following different hormonal triggers of oocyte maturation in IVF treatment
Authors: Abbara A. , Islam R. , Clarke S.A. , Jeffers L. , Christopoulos G. , Comninos A.N. , Salim R. , Lavery S.A. , Vuong T.N.L. , Humaidan P. , Kelsey T.W. , Trew G.H. , Dhillo W.S. 
Published: February 2018

SummaryObjectiveOvarian hyperstimulation syndrome (OHSS) is a serious iatrogenic condition, predominantly related to the hormone used to induce oocyte maturation during IVF treatment. Kisspeptin is a hypothalamic neuropeptide that has recently been demonstrated to safely trigger final oocyte maturation during IVF treatment even in women at high risk of OHSS. However, to date, the safety of kisspeptin has not been compared to current hormonal triggers of oocyte maturation.DesignWe conducted a retrospective single‐centre cohort study investigating symptoms and clinical parameters of early OHSS in women at high risk of OHSS (antral follicle count or total number of follicles on day of trigger ≥23) triggered with human chorionic gonadotrophin (hCG) (n = 40), GnRH agonist (GnRHa; n = 99) or kisspeptin (n = 122) at Hammersmith Hospital IVF unit, London, UK (2013‐2016).ResultsClinical Parameters of OHSS: Median ovarian volume was larger following hCG (138 ml) than GnRHa (73 ml; P < .0001), and in turn kisspeptin (44 ml; P < .0001). Median ovarian volume remained enlarged 20‐fold following hCG, 8‐fold following GnRHa and 5‐fold following kisspeptin compared to prestimulation ovarian volumes. Mean (±SD) ascitic volumes were lesser following GnRHa (9 ± 44 ml) and kisspeptin (5 ± 8 ml) than hCG (62 ± 84 ml; P < .0001). Symptoms of OHSS were most frequent following hCG and least frequent following kisspeptin. Diagnosis of OHSS: The odds ratio for OHSS diagnosis was 33.6 (CI 12.6‐89.5) following hCG and 3.6 (CI 1.8‐7.1) following GnRHa, when compared to kisspeptin.ConclusionTriggering oocyte maturation by inducing endogenous gonadotrophin release is preferable to the use of exogenous hCG in women at high risk of OHSS.
Injection testosterone and adverse cardiovascular events: A case‐crossover analysis
Authors: Layton J. Bradley , Li Dongmei , Meier Christoph R. , Sharpless Julie L. , Stürmer Til , Brookhart M. Alan 
Published: February 2018

SummaryContextExogenous testosterone administration may affect blood clotting, polycythaemia, and may increase atherosclerosis, though any association with cardiovascular events is unclear. While the literature is inconclusive, some studies have suggested testosterone use may increase short‐term risk of cardiovascular events and stroke, and injection testosterone may convey higher risks than other dosage forms.ObjectiveWe sought to evaluate the short‐term cardiovascular risk of receiving injection testosterone.DesignWe conducted a case‐crossover analysis comparing injection testosterone exposure in the 7 days prior to an outcome event to referent windows in the past to estimate the acute association of cardiovascular outcomes with the receipt of testosterone injections.PatientsWe identified adult male testosterone users hospitalized with myocardial infarction (MI), stroke or a composite of MI, stroke or unstable angina in US commercial claims (2000‐2013) or Medicare (2007‐2010) databases.MeasurementsWe identified testosterone use for the patients from pharmacy dispensing claims or in‐office procedure codes in the insurance billing data.ResultsWe identified 2898 commercially insured men with events and recent testosterone use, and 339 from Medicare. Injected testosterone was associated with an increased risk of adverse events (composite outcome of myocardial infarction, stroke or unstable angina) in the immediate postinjection period for the older, Medicare population only: commercial insurance, odds ratios (OR) = 0.98 (95% confidence intervals [CI]: 0.86‐1.12); Medicare, OR = 1.45 (1.07, 1.98). This association was either greatly attenuated or not present when evaluating receipt of any testosterone dosage forms (injection, gel, patch, implant): commercial insurance, OR = 1.01 (0.92, 1.11); Medicare, OR = 1.26 (95% CI: 0.98‐1.63).ConclusionsTestosterone injections were uniquely associated with short‐term risk of acute cardio‐ and cerebrovascular events in older adult men following injection receipt.