bluuebunny/crossref_metadata_2025_split huggingface dataset:
The decision to biopsy in a lung cancer screening program: Potential impact of risk calculators
Authors: Gilbert Christopher R , Carlson Alexander S , Wilshire Candice L , Aye Ralph W , Farivar Alexander S , Bograd Adam J , Gorden Jed A 
Published: November 2018

Objective The National Lung Screening Trial demonstrated the benefits of lung cancer screening, but the potential high incidence of unnecessary invasive testing for ultimately benign radiologic findings causes concern. We aimed to review current biopsy patterns and outcomes in our community-based program, and retrospectively apply malignancy prediction models in a lung cancer screening population, to identify the potential impact these calculators could have on biopsy decisions. Methods Retrospective review of lung cancer-screening program participants from 2013 to 2016. Demographic, biopsy, and outcome data were collected. Malignancy risk calculators were retrospectively applied and results compared in patients with positive imaging findings. Results From 520 individuals enrolled in the screening program, pulmonary nodule(s) ≥6 mm were identified in 166, with biopsy in 30. Malignancy risk probabilities were significantly higher (Brock p < 0.00001; Mayo p < 0.00001) in those undergoing diagnostic sampling than those not undergoing sampling. However, there was no difference in the Brock ( p = 0.912) or Mayo ( p = 0.435) calculators when discriminating a final diagnosis of cancer from not cancer in those undergoing sampling. Conclusions In our screening program, 5.7% of individuals undergo invasive testing, comparable with the National Lung Screening Trial (6.1%). Both Brock and Mayo calculators perform well in indicating who may be at risk of malignancy, based on clinical and radiologic factors. However, in our invasive testing group, the Brock and Mayo calculators and Lung Cancer Screening Program clinical assessment all lacked clarity in distinguishing individuals who have a cancer from those with a benign abnormality.
Muscular strength and function after total hip arthroplasty performed with three different surgical approaches: one-year follow-up study
Authors: Winther Siri B , Foss Olav A , Husby Otto S , Wik Tina S , Klaksvik Jomar , Husby Vigdis S 
Published: November 2018

Background: Surgical approach influences short-term muscular strength, and leg-strength asymmetry has been demonstrated after total hip arthroplasty (THA). We evaluated muscular strength, physical function and patient-reported outcome measures (PROMs) up to 12 months postoperatively, in patients operated on using 3 different surgical approaches. Methods: 60 patients scheduled for primary THA were allocated to the direct lateral (DLA), posterior (PA) or anterior (AA) approach. The following parameters were evaluated: leg press and abduction strength, pain, 6-minute walking test, Harris Hip Score and Hip disability and Osteoarthritis Outcome Score - Physical Function Shortform (HOOS-PS). Results: Abduction strength in the DLA group was significantly more reduced than the PA and AA groups 12 months postoperatively ( p < 0.001). A significant interleg difference in abduction ( p < 0.01) and leg press ( p < 0.03) persisted in all groups up to 6 months, and up to 12 months in the DLA ( p < 0.05). In the AA group, interleg difference in leg press was present up to 12 months ( p = 0.01). Pain scores were higher in the DLA than the AA group at 6 months ( p = 0.01). Patients in the PA group had better HOOS-PS score than those in the DLA group 3 months postoperatively ( p = 0.02). No intergroup differences in pain or PROMs were found 12 months postoperatively. Conclusion: Patients operated via the DLA had reduced muscular strength, HOOS-PS scores and higher pain scores than those who underwent PA and AA type surgery. The non-operated leg was significantly stronger than the operated leg in all groups 6 months postoperatively and this persisted up to 12 months postoperatively for the DLA and AA groups. Clinical Trial Protocol number: ClinicalTrials.gov (NCT01506024).
An analysis of potential predictors of tunneled hemodialysis catheter infection or dysfunction
Authors: Coker M Austin , Black J Ryne , Li Yufeng , Varma Rakesh , Almehmi Ammar , Abdel Aal Ahmed K , Gunn Andrew J 
Published: November 2018

Purpose: To assess the ability of various clinical factors to predict infection or dysfunction of tunneled hemodialysis catheters. Methods: A retrospective review of all adult patients who had a tunneled hemodialysis catheter placed between 2012 and 2016 was performed. Tunneled hemodialysis catheters were considered infected based on clinical suspicion or culture-positive bacteremia. Dysfunction was defined as all other non-infectious causes for line failure. Time-to-removal or exchange was recorded. Clinical parameters analyzed as potential predictors of tunneled hemodialysis catheter infection or dysfunction, included the following: age, sex, site of placement, inpatient versus outpatient status at time of placement, body mass index, Charlson Comorbidity Index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, platelet count, white blood cell count, international normalized ratio, and partial thromboplastin time. Results: A total of 177 patients (95: female, 82: male; 71.7%: African American; mean age: 54.9 years) qualified for inclusion. The internal jugular vein was the site of placement in 97.1% of patients with 79.7% of lines being placed on the right side. One patient (0.5%) had minor bleeding after catheter insertion but no other complications were recorded. A total of 17 patients (9.6%) had lines removed or exchanged due to infection at a median of 86 (range: 13–626) days, while 68 patients (38.4%) had lines removed or exchanged due to dysfunction at a median of 42 (range: 1–531) days. A total of 92 patients (51.9%) had lines removed due to completion of therapy at a median of 68 (range: 7–433) days. Dysfunctional lines had a shorter time-to-removal than successful lines ( p = 0.007). No difference was seen in time-to-removal between infected lines and successful lines ( p = 0.16). Multivariate analysis showed that female sex ( p = 0.003) and left-sided line placement ( p = 0.007) were independent predictors of line dysfunction. No evaluated factors were predictive of tunneled hemodialysis catheter infection. Conclusion: Female sex and left-sided line placement were independent predictors of tunneled hemodialysis catheter dysfunction, but none of the evaluated parameters predicted tunneled hemodialysis catheter infection.
Incidence of tenolysis and features of adhesions in the digital flexor tendons after multi-strand repair and early active motion
Authors: Moriya Koji , Yoshizu Takea , Tsubokawa Naoto , Narisawa Hiroko , Maki Yutaka 
Published: November 2018

We report seven patients requiring tenolysis after primary or delayed primary flexor tendon repair and early active mobilization out of 148 fingers of 132 consecutive patients with Zone 1 or 2 injuries from 1993 to 2017. Three fingers had Zone 2A, two Zone 2B, and two Zone 2C injuries. Two fingers underwent tenolysis at Week 4 or 6 after repair because of suspected repair rupture. The other five fingers had tenolysis 12 weeks after repair. Adhesions were moderately dense between the flexor digitorum superficialis and profundus tendons or with the pulleys. According to the Strickland and Tang criteria, the outcomes were excellent in one finger, good in four, fair in one, and poor in one. Fingers requiring tenolysis after early active motion were 5% of the 148 fingers so treated. Indications for tenolysis were to achieve a full range of active motion in the patients rated good or improvement of range of active motion of the patients rated poor or fair. Not all of our patients with poor or fair outcomes wanted to have tenolysis. Level of evidence: IV
The transmembrane protein disulfide isomerase TMX1 negatively regulates platelet responses
Authors: Zhao Zhenzhen , Wu Yi , Zhou Junsong , Chen Fengwu , Yang Aizhen , Essex David W. 
Published: November 2018

AbstractSecreted platelet protein disulfide isomerases, PDI, ERp57, ERp5, and ERp72, have important roles as positive regulators of platelet function and thrombosis. Thioredoxin-related transmembrane protein 1 (TMX1) was the first described transmembrane member of the protein disulfide isomerase family of enzymes. Using a specific antibody, the recombinant extracellular domain of TMX1 (rTMX1) protein, a knockout mouse model, and a thiol-labeling approach, we examined the role of TMX1 in platelet function and thrombosis. Expression of TMX1 on the platelet surface increased with thrombin stimulation. The anti-TMX1 antibody increased platelet aggregation induced by convulxin and thrombin, as well as potentiated platelet ATP release. In contrast, rTMX1 inhibited platelet aggregation and ATP release. TMX1-deficient platelets had increased aggregation, ATP release, αIIbβ3 activation, and P-selectin expression, which were reversed by addition of rTMX1. TMX1-knockout mice had increased incorporation of platelets into a growing thrombus in an FeCl3-induced mesenteric arterial injury model, as well as shortened tail-bleeding times. rTMX1 oxidized thiols in the αIIbβ3 integrin and TMX1-deficient platelets had increased thiols in the β3 subunit of αIIbβ3, consistent with oxidase activity of rTMX1 against αIIbβ3. Thus, TMX1 is the first identified extracellular inhibitor of platelet function and the first disulfide isomerase that negatively regulates platelet function.
Collaborative Physician-Pharmacist–Managed Multiple Myeloma Clinic Improves Guideline Adherence and Prevents Treatment Delays
Authors: Sweiss Karen , Wirth Scott M. , Sharp Lisa , Park Irene , Sweiss Helen , Rondelli Damiano , Patel Pritesh R. 
Published: November 2018

Purpose: We hypothesized that a multidisciplinary collaborative physician-pharmacist multiple myeloma clinic would improve adherence to treatment and supportive care guidelines as well as reduce delays in receiving oral antimyeloma therapy. Methods: From March 2014 to February 2015, an oncology pharmacist provided consultation for all patients in a specialist myeloma clinic. This included reviewing medications, ensuring physician adherence to supportive care guidelines, managing treatment-related adverse effects, and navigating issues involving access to oral specialty medications (collaborative clinic). Results: Outcome measures were retrospectively compared with those of patients being treated by the same physician during the previous year, in which ad hoc pharmacist consultation was available upon request (traditional clinic). The collaborative clinic led to significant improvements in adherence to supportive medications, such as bisphosphonates (96% v 68%; P < .001), calcium and vitamin D (100% v 41%; P < .001), acyclovir (100% v 58%; P < .001), and Pneumocystis jirovecii pneumonia prophylaxis (100% v 50%; P < .001). Appropriate venous thromboembolism prophylaxis in immunomodulatory drug–treated patients was prescribed in 100% versus 83% of cases ( P = .0035). The median time to initiation of bisphosphonate (5.5 v 97.5 days; P < .001) and P jirovecii pneumonia prophylaxis after autologous transplantation was shortened in the collaborative clinic (11 v 40.5 days; P < .001). Furthermore, the number (85% v 21%; P < .001) and duration (7 v 15 days; P = .002) of delays in obtaining immunomodulatory drug therapy were also significantly reduced. Conclusion: Our collaborative clinic model could potentially be applied to other practice sites to improve the management of patients with multiple myeloma. Prospective studies analyzing clinical outcomes, patient satisfaction, and cost effectiveness of this approach are warranted.
Share of Oncology Versus Nononcology Spending in Episodes Defined by the Centers for Medicare & Medicaid Services Oncology Care Model
Authors: Baumgardner James R. , Shahabi Ahva , Linthicum Mark T. , Zacker Christopher , Lakdawalla Darius N. 
Published: November 2018

Purpose: Performance-based payments to oncology providers participating in the Centers for Medicare & Medicaid Services (CMS) Oncology Care Model (OCM) are based, in part, on overall spending in 6-month episodes of care, including spending unrelated to oncology care. The amount of spending likely to occur outside of oncologists’ purview is unknown. Methods: Following the OCM definition of an episode, we used SEER-Medicare data from 2006 to 2013 to identify episodes of cancer care for the following diagnoses: breast cancer (BC), non–small-cell lung cancer, renal cell carcinoma, multiple myeloma (MM), and chronic myeloid leukemia. Claims were categorized by service type and, separately, whether the content fell within the purview of oncology providers (classified as oncology, with all other claims nononcology). We calculated the shares of episode spending attributable to oncology versus nononcology services. Results: The percentage of oncology spending within OCM episodes ranged from 62.4% in BC to 85.5% in MM. The largest source of oncology spending was antineoplastic drug therapy, ranging from 21.8% of total episode spending in BC to 67.6% in chronic myeloid leukemia. The largest source of nononcology spending was acute hospitalization and inpatient physician costs, ranging from 6.6% of overall spending for MM to 10.4% for non–small-cell lung cancer; inpatient oncology spending contributed roughly similar shares to overall spending. Conclusion: Most spending in OCM-defined episodes was attributable to services related to cancer care, especially antineoplastic drug therapy. Inability to control nononcology spending may present challenges for practices participating in the OCM, however.
The Association Between Continuity of Primary Care and Preventive Cancer Screening in Women With Intellectual Disability
Authors: Plourde Natasha , Brown Hilary K. , Vigod Simone , Cobigo Virginie 
Published: November 2018

AbstractWomen with intellectual disability have low screening rates for breast and cervical cancer. This population-based cohort study examined the association between the level of primary care continuity and breast and cervical cancer screening rates in women with intellectual disability. Data were obtained from the Institute for Clinical Evaluative Sciences and the Ontario Ministry of Community and Social Services. Neither high (adjusted OR [aOR] = 1.06; 95% CI: 0.88-1.29) nor moderate (aOR = 1.11; 95% CI: 0.91-1.36) continuity of care were associated with mammography screening. Women were less likely to receive a Pap test with high (aOR = 0.70; 95% CI: 0.64-0.77) and moderate (aOR = 0.81, 95% CI 0.74-0.89) versus low continuity of care. Improving continuity of care may not be sufficient for increasing preventive screening rates.
Associations Between Medical History, Cognition, and Behavior in Youth With Down Syndrome: A Report From the Down Syndrome Cognition Project
Authors: Rosser Tracie C. , Edgin Jamie O. , Capone George T. , Hamilton Debra R. , Allen Emily G. , Dooley Kenneth J. , Anand Payal , Strang John F. , Armour A. Chelsea , Frank-Crawford Michelle A. , Channell Marie Moore , Pierpont Elizabeth I. , Feingold Eleanor , Maslen Cheryl L. , Reeves Roger H. , Sherman Stephanie L. 
Published: November 2018

Abstract
The cause of the high degree of variability in cognition and behavior among individuals with Down syndrome (DS) is unknown. We hypothesized that birth defects requiring surgery in the first years of life (congenital heart defects and gastrointestinal defects) might affect an individual's level of function. We used data from the first 234 individuals, age 6-25 years, enrolled in the Down Syndrome Cognition Project (DSCP) to test this hypothesis. Data were drawn from medical records, parent interviews, and a cognitive and behavior assessment battery. Results did not support our hypothesis. That is, we found no evidence that either birth defect was associated with poorer outcomes, adjusting for gender, race/ethnicity, and socioeconomic status. Implications for study design and measurement are discussed.
Psychometric Properties of the Spanish Version of the Self-Determination Inventory Student Self-Report: A Structural Equation Modeling Approach
Authors: Mumbardó-Adam Cristina , Guàrdia-Olmos Joan , Giné Climent , Shogren Karrie A. , Vicente Sánchez Eva 
Published: November 2018

Abstract
Instruments to measure self-determination have only been available in the Spanish language to date, for adolescents with intellectual disability (ID). However, given the development of a new measure of self-determination for youth with and without disabilities, the Self-Determination Inventory, there is a need to adapt and validate this tool in the Spanish language so as to provide practitioners with a psychometrically strong measure of self-determination. This study provides evidence of reliability and validity of the Spanish version of the scale, empirically tested with a sample of 620 youth with and without disabilities in Spain. Specifically, validity was evidenced through structural equation modeling approaches, confirming the instrument adequacy to measure self-determination in Spanish speaking youth. Future lines of research are suggested.
The rise of genetically engineered mouse models of pancreatitis: A review of literature
Authors: Merry Troy L. , Petrov Maxim S. 
Published: November 2018

AbstractPancreatitis is increasingly recognized as not merely a local inflammation of the pancreas but also a disease with high frequency of systemic sequelae. Current understanding of the cellular mechanisms that trigger it and affect the development of sequelae are limited. Genetically engineered mouse models can be a useful tool to study the pathophysiology of pancreatitis. This article gives an overview of the genetically engineered mouse models that spontaneously develop pancreatitis and discusses those that most closely replicate different pancreatitis hallmarks observed in humans.
Therapeutic Application of Zinc and Vanadium Complexes against Diabetes Mellitus a Coronary Disease: A review
Authors: Azam Aisha , Raza Muhammad Asam , Sumrra Sajjad Hussain 
Published: November 2018

Abstract
During the last two decades, number of peoples suffering from diabetes has increased from 30-230 million globally. Today, seven out of the ten top countries are suffering from diabetes, are emergent countries. Due to alarming situations of diabetes, chemists and pharmacist are continuously searching and synthesizing new potent therapeutics to treat this disease. Now a days, considerable attention is being paid to the chemistry of the metal-drug interactions. Metals and their organic based complexes are being used clinically for various ailments. In this review, a comprehensive discussion about synthesis and diabetic evaluation of zinc and vanadium complex is summarized.
K-theory classification of graded ultramatricial algebras with involution
Authors: Hazrat Roozbeh , Vaš Lia 
Published: November 2018

Abstract
We consider a generalization

K
0
gr

⁢

(
R
)

{K_{0}^{\operatorname{gr}}(R)}

of the standard Grothendieck group

K
0

⁢

(
R
)

{K_{0}(R)}

of a graded ring R with involution. If Γ is an abelian group, we show that

K
0
gr

{K_{0}^{\operatorname{gr}}}

completely classifies graded ultramatricial

*

{*}

-algebras over a Γ-graded

*

{*}

-field A such that
(1) each nontrivial graded component of A has a unitary element in which case we say that A has enough unitaries, and (2) the zero-component

A
0

{A_{0}}

is 2-proper (

a
⁢

a
*

+

b
⁢

b
*

=
0

{aa^{*}+bb^{*}=0}

implies

a
=
b
=
0

{a=b=0}

for any

a
,
b

∈

A
0

{a,b\in A_{0}}

) and

*

{*}

-pythagorean (for any

a
,
b

∈

A
0

{a,b\in A_{0}}

one has

a
⁢

a
*

+

b
⁢

b
*

=

c
⁢

c
*

{aa^{*}+bb^{*}=cc^{*}}

for some

c
∈

A
0

{c\in A_{0}}

). If the involutive structure is not considered, our result implies that

K
0
gr

{K_{0}^{\operatorname{gr}}}

completely classifies graded ultramatricial algebras over any graded field A. If the grading is trivial and the involutive structure is not considered, we obtain some well-known results as corollaries.
If R and S are graded matricial

*

{*}

-algebras over a Γ-graded

*

{*}

-field A with enough unitaries and

f
:

K
0
gr

⁢

(
R
)

→

K
0
gr

⁢

(
S
)

{f:K_{0}^{\operatorname{gr}}(R)\to K_{0}^{\operatorname{gr}}(S)}

is a contractive

ℤ
⁢

[
Γ
]

{\mathbb{Z}[\Gamma]}

-module homomorphism, we present a specific formula for a
graded

*

{*}

-homomorphism

ϕ
:

R
→
S

{\phi:R\to S}

with

K
0
gr

⁢

(
ϕ
)

=
f

{K_{0}^{\operatorname{gr}}(\phi)=f}

. If the grading is trivial and the involutive structure is not considered, our constructive proof implies the known results with existential proofs. If

A
0

{A_{0}}

is 2-proper and

*

{*}

-pythagorean, we also show that two graded

*

{*}

-homomorphisms

ϕ
,
ψ

:

R
→
S

{\phi,\psi:R\to S}

are such that

K
0
gr

⁢

(
ϕ
)

=

K
0
gr

⁢

(
ψ
)

{K_{0}^{\operatorname{gr}}(\phi)=K_{0}^{\operatorname{gr}}(\psi)}

if and only if there is a unitary element u of degree zero in S such that

ϕ
⁢

(
r
)

=

u
⁢
ψ
⁢

(
r
)

⁢

u
*

{\phi(r)=u\psi(r)u^{*}}

for any

r
∈
R

{r\in R}

.
As an application of our results, we show that the graded version of the Isomorphism Conjecture holds for a class of Leavitt path algebras:
if E and F are countable, row-finite, no-exit graphs in which every infinite path ends in a sink or a cycle and K is a 2-proper and

*

{*}

-pythagorean field, then the Leavitt path algebras

L
K

⁢

(
E
)

{L_{K}(E)}

and

L
K

⁢

(
F
)

{L_{K}(F)}

are isomorphic as graded rings if any only if they are isomorphic as graded

*

{*}

-algebras. We also present examples which illustrate that

K
0
gr

{K_{0}^{\operatorname{gr}}}

produces a finer invariant than

K
0

{K_{0}}

.
Dynamic Reclamation Methods for Subsidence Land in the Mining Area with High Underground Water Level
Authors: Chen Qiuji , Hang Mengru 
Published: November 2018

AbstractDynamic reclamation for subsidence land is a development trend of ecological restoration in the mining area. It emphasizes that treatments should be taken during or before land damage to control the ecological degradation. Because dynamic reclamation is a complex problem, there still exist many challenges that have to be studied for practical application. In this paper, taking subsidence land in the area with high underground water level as an example, according to the requirements of land use and economic development, key techniques for dynamic reclamation are analyzed based on mine subsidence theories. The research proposes a general mode for dynamic reclamation, and provides a method for calculating the control time of soil excavation, and puts forth an optimization thought for land use, then establishes a procedure for soil reconstruction. The results show that dynamic reclamation can reduce the cost and shorten the land waste time, and enhance the sustainable development ability of the mining area.
Synthesis and fungicidal activities of 2-{[(2-(1H-1,2,4-triazol-1-yl)-ethylidene)amino]oxy}alkanamides containing dihydrobenzofuran
Authors: Wan Li , Zihui Yang , Aixi Hu , Jiao Ye , Xiaoming Ou , Hui Pei , Lian He , Jianming Li 
Published: November 2018

Abstract
In order to find new compounds with high fungicidal activity, acetamide derivatives 4a–x were rationally designed, synthesized, characterized and tested against various fungi in vivo. The bioassay results indicate that compounds 4k,m,o,r exhibit an 80% inhibition rate against Rhizoctonia solani at 500 mg/L, and compound 4j shows an 80% inhibition rate against Blumeria graminis at 500 mg/L. Therefore, compounds of 4 are promising fungicidal candidates worthy of further development.