bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of videotaped personal compulsions to enhance motivation in obsessive–compulsive disorder
Authors: du Mortier Johanna A. M. , Visser Henny A. D. , van Geijtenbeek - de Vos van Steenwijk Malinda F. R. , van Megen Harold J. G. M. , van Balkom Anton J. L. M. 
Published: January 2019

BackgroundWatching videotaped personal compulsions together with a therapist might enhance the effect of cognitive–behavioural therapy in obsessive–compulsive disorder (OCD) but little is known about how patients experience this.AimsTo performed a qualitative study that describes how watching these videos influences motivation for treatment and whether patients report any adverse events.MethodIn this qualitative study, data were gathered in semi-structured interviews with 24 patients with OCD. The transcripts were coded by two researchers. They used a combination of open and thematic coding and discrepancies in coding were discussed.ResultsThe experience of watching videos with personal compulsions helped patients to realise that these compulsions are aberrant and irrational. Patients report increased motivation to resist their OCD and to adhere to therapy. No adverse events were reported.ConclusionsVideos with personal compulsions create more awareness in patients with OCD that compulsions are irrational, leading to enhanced motivation for treatment.Declaration of interestNone.
Complete assembly of a dengue virus type 3 genome from a recent genotype III clade by metagenomic sequencing of serum
Authors: Dias Mary , Pattabiraman Chitra , Siddappa Shilpa , Gowda Malali , Shet Anita , Smith Derek , Muehlemann Barbara , Tamma Krishnapriya , Solomon Tom , Jones Terry , Krishna Sudhir 
Published: January 2019

Background:Mosquito-borne flaviviruses, such as dengue and Japanese encephalitis virus (JEV), cause life-threatening diseases, particularly in the tropics.Methods:Here we performed unbiased metagenomic sequencing of RNA extracted from the serum of four patients and the plasma of one patient, all hospitalized at a tertiary care centre in South India with severe or prolonged febrile illness, together with the serum from one healthy control, in 2014.Results:We identified and assembled a complete dengue virus type 3 sequence from a case of severe dengue fever. We also identified a small number of JEV sequences in the serum of two adults with febrile illness, including one with severe dengue. Phylogenetic analysis revealed that the dengue sequence belonged to genotype III. It has an estimated divergence time of 13.86 years from the most highly related Indian strains. In total, 11 amino acid substitutions were predicted for this strain in the antigenic envelope protein, when compared to the parent strain used for development of the first commercial dengue vaccine. Conclusions:We demonstrate that both genome assembly and detection of a low number of viral sequences are possible through the unbiased sequencing of clinical material. These methods may help ascertain causal agents for febrile illnesses with no known cause.
IMAGENS EM BLOGS EDUCACIONAIS DE LÍNGUA INGLESA E AS POSSIBILIDADES DE SEUS USOS NA PRÁTICA PEDAGÓGICA
Authors: Sagres Ofélia Da Conceição Machado , Santos Rosemary Dos 
Published: January 2019

Este artigo é fruto da monografia final do Curso de Especialização do Programa de Pós-Graduação com Aplicação da Informática (EDAI) na UERJ. Tem como objetivo analisar o papel das imagens em blogs voltados para o ensino de Língua Inglesa. Quanto à metodologia empregada, optamos pelo estudo de caso, pois este propicia a pesquisa qualitativa de eventos autênticos e atuais. Este estudo baseou-se em teorias a respeito de comunicação e multimodalidade e em questões como: criação digital em rede, multiletramentos, facilidade e multiplicidade de interpretações e em usos dos blogs como ambientes de aprendizagens. Assim, dialogamos com autores da semiótica e dos estudos das tecnologias digitais. Como achados da pesquisa destacamos que os recursos digitais visuais podem ser usados para trabalhar conteúdos, trocar informações e construir atividades sem as limitações do meio físico. Blogs, wikis e redes sociais, assim, passam a ser ambientes educativos, uma vez que são capazes de criar situações de aprendizagem para alunos e educadores.
Consequências diretas da má conservação das estradas com vistas ao consumo de combustível, velocidade média e desgaste dos pneumáticos
Authors: Magalhães Eduardo Nunes , Da Silva Paulo Caetano 
Published: January 2019

O Brasil possui uma enorme extensão territorial e, 60% do transporte de suas cargas fluem pelas rodovias federais, estaduais e municipais. Sendo assim, o transporte de carga gira um negócio bilionário em todo o país capaz de promover o desenvolvimento. Contudo, na mesma medida da importância dessa modalidade de transporte está o descaso da classe governante do país com a construção e manutenção das estradas brasileiras. Isso tem promovido um incremento nos custos do transporte e, consequentemente, na cadeia produtiva de vários produtos, impactando diretamente seus preços. Existem poucos estudos sobre o impacto direto da má conservação das estradas na economia e grande parte do que existe é feito pela Confederação Nacional dos Transportes- CNT. Essa falta de dados sobre o setor se deve ora pela dificuldade no controle das variáveis, ora pela complexidade do assunto. O presente estudo teve por objetivo analisar três parâmetros fundamentais que é o consumo de combustível (Km/L), velocidade média (Km/h) e desgaste dos pneumáticos. Para isso, foi realizada a coleta dos dados em 21 viagens, em duas rotas conhecidas, a saber: Patos de Minas-MG a Fortaleza-CE e Patos de Minas-MG a Santa Maria- RS. A primeira possui condições piores de tráfego em mais de 60% do trecho, tais como pista irregular e com buracos, má sinalização, falta de acostamento, dentre outras.. Os resultados demonstram haver diferenças estatísticas entre as rotas para os três parâmetros estudados, sendo que os mais negativos foram encontrados nos trechos onde há piores condições de conservação.
Detection and Characterization of Circulating Tumor Cells in Patients with Merkel Cell Carcinoma
Authors: Riethdorf Sabine , Hildebrandt Lina , Heinzerling Lucie , Heitzer Ellen , Fischer Nicole , Bergmann Sonja , Mauermann Oliver , Waldispühl-Geigl Julie , Coith Cornelia , Schön Gerhard , Peine Sven , Schuler Gerold , Speicher Michael R , Moll Ingrid , Pantel Klaus 
Published: January 2019

AbstractBACKGROUNDMerkel cell carcinoma (MCC) is a rare, aggressive skin cancer with increasing incidence and high mortality rates. MCC has recently become the subject of immune checkpoint therapy, but reliable biomarkers for estimating prognosis, risk stratification, and prediction of response are missing.METHODSCirculating tumor cells (CTCs) were detected in peripheral blood from patients with MCC by use of the CellSearch® system. Moreover, CTCs of selected cases were characterized for Merkel cell polyomavirus (MCPyV), chromosomal aberrations, and programed death ligand 1 (PD-L1) production.RESULTSFifty-one patients were tested at first blood draw (baseline), and 16 patients had 2 or 3 consecutive measurements to detect CTCs. At baseline, ≥1 CTC (range, 1–790), &gt;1, or ≥5 CTCs/7.5 mL were detected in 21 (41%), 17 (33%), and 6 (12%) patients, respectively. After a median follow-up of 21.1 months for 50 patients, detection of CTCs correlated with overall survival (≥1, P = 0.030; &gt;1, P &lt; 0.020; and ≥5 CTCs/7.5 mL, P &lt; 0.0001). In multivariate Cox regression analysis, the detection of ≥5 CTCs/7.5 mL adjusted to age and sex compared to that of &lt;5 was associated with a reduced overall survival (P = 0.001, hazard ratio = 17.8; 95% CI, 4.0–93.0). MCPyV DNA and genomic aberrations frequently found in MCC tissues could also be detected in single CTCs. Analyzed CTCs were PD-L1 negative or only weakly positive.CONCLUSIONSThe presence of CTCs is a prognostic factor of impaired clinical outcome, with the potential to monitor the progression of the disease in real time. Molecular characterization of CTCs might provide new insights into the biology of MCC.
À conquista da sabedoria. A pintura de quadratura e o programa iconográfico da Biblioteca Joanina
Authors: Raggi Giuseppina 
Published: January 2019

O artigo propõe a releitura do processo de construção e decoração da Biblioteca da Universidade de Coimbra, conhecida como Biblioteca Joanina (1716-1728). O texto reinterpreta o contexto artístico e cultural da primeira metade do reinado de D. João V (1707- acerca de 1728) e o impacto dos projetos do arquiteto italiano Filippo Juvarra para a nova cidade de Lisboa (1719). A construção da Biblioteca Joanina integrou o plano de renovação do conhecimento em todos os campos do saber promovido por D. João V, pela rainha D. Maria Ana de Áustria e pela corte portuguesa. Desta forma, o artigo oferece uma nova interpretação do programa iconográfico, baseado na metáfora militar. A Biblioteca torna-se fortaleza da Sabedoria que o estudante-soldado é chamado a conquistar. No interior, o espaço do conhecimento é dividido em três etapas progressivas: o espaço da adquisição dos novos saberes (Imago Bibliotecae); do conhecimento académico (Universitas) e do enciclopédico (Enciclopedia). Porém, o verdadeiro objetivo final é alcançar a sabedoria do Sabio Cristão, tal como a descreve padre Rafael Bluteau nas suas Prosas Academicas… (1717-1728). Chegando ao fim do seu percurso, depostas as armas aos pés do soberano, o estudante-conquistador espelha-se no retrato de rei D. João V, imagem vivente do Sabio Cristão. O texto aprofunda, também, os seguintes tópicos: 1) as conexões artísticas com a arquitetura italiana e austríaca; 2) as estreitas relações entre a pintura de arquiteturas em perspetiva, realizada nos três tetos da Biblioteca Joanina por António Simões Ribeiro e Vicente Nunes, e a tradição da “quadratura” bolonhesa; 3) a carência de fornecimento de livros para a Biblioteca da Universidade de Coimbra, depois da conclusão do edifício e ao longo da segunda metade do reino de D. João V; 4) a reinterpretação da quadratura dos tetos da Biblioteca Joanina por António Augusto Gonçalves no século XIX; 5) as obras de restauro promovidas pela Direção dos Monumentos Nacionais entre 1931 e 1934 e o envolvimento do pintor Joaquim Lopes, Professor de artes no Porto.
Fundo Doutor Luís de Albuquerque da Biblioteca Geral da Universidade de Coimbra
Authors: De Carvalho Maria de Fátima Moura 
Published: January 2019

Luís de Albuquerque nascido em 1917 e falecido em 1992, foi um brilhante professor da Faculdade de Ciências da Universidade de Coimbra, embora também colaborasse com a Faculdade de Letras. Foi também Diretor da Biblioteca Geral entre 1978 e 1987, a quem fez a doação da sua Biblioteca Pessoal, composta por monografias, recursos contínuos e manuscritos. O Fundo inclui publicações de áreas muito variadas, mas predominantemente de Ciências Exatas e História.
Speech Outcome in Cleft Palate Patients After Soft Palatoplasty (Stage 1) in Two-Stage Palatoplasty Technique: A Review of Two Cases
Authors: Sutrisno Eddy H , Wahyuni Luh K. , Lilisantosa Kartika 
Published: January 2019

Background: The challenge in palatoplasty is no longer a successful closure of the cleft palate but an optimal speech outcome without compromising maxillofacial growth. On the contrary, repairing cleft palate as soon as possible is recommended to improve speech. The surgeon proposed two-stage palatoplasty in early aged, range between 4 to 30 months. The delayed hard palate closure started approximately between the age of three years and one year after soft palatoplasty to avoid temporary retracted oral articulation of certain consonant. Patient and Methods: 11-months old and 9-months old patients with non-syndromic unilateral cleft lip and palate had undergone soft palatoplasty. Speech was examined as a perceptual assessment, using protocol in Craniomaxillofacial Center Cipto Mangunkusumo Hospital, in the age of 29 months by an experienced speech pathologist. Result: Patient 1 has mild hypernasality, adequate velopharyngeal competence, normal articulation pattern, phonation and speech intelligibility. Patient 2 has misarticulation pattern,which are omission or weak consonants, substitution of pharyngeal stop, mild to moderate hypernasality, mild impairment in speech intelligibility, and inadequate velopharyngeal competence.Summary: Speech outcome is influenced by intense speech practicing done by their parents. The patient can work on the misarticulation. We need further study to know the result of speech outcome in two stage palatoplasty.
Breast Augmentation in Swyer Syndrome Patient
Authors: Tania Vika , Wardhana Aditya 
Published: January 2019

Background: The number of breast augmentation in Indonesia has been raised, especially in young women. Women with disorders of sex development (DSD) can be one of our patients that come for breast augmentation. These patients may also have other problems that can lead to serious disease in her later life, such as malignancies which has 30% probability.Patients and Methods: We report one case of female with 46 XY karyotype and normal female phenotype. She appeared to be normal female but did not develop secondary sexual characteristics at puberty with Tanner classi!cation M1P1, did not menstruate, and had streak gonads in ovarian localization. This gonadal dysgenesis syndrome is also called Swyer syndrome.Result: A clinical team consists of plastic surgeons, gynecologist, psychiatrist, geneticist was build to manage our patient comprehensively. We performed breast augmentation, laparoscopic gonadectomy, and psychological support.Summary: Patient with disorder of sex development (DSD) can be one of our patients who come for breast augmentation. One must pay attention to subtle sign leading to DSD patients such as, history of amenorrhea, wide chest and lack of women body curve. Complete evaluation of sexual development is needed before performing breast augmentation.
Social and economic potential of Azerbaijani migrants who entered Russia in 2014-2017
Authors: Endryushko Anna A. 
Published: January 2019

The article analyzes social and economic features, employment, well-being and housing conditions of the Azerbaijani migrants who came to Russia in 2014-2017. The empirical basis of the study is the data of a Russian nationwide survey of migrants. The survey was conducted by the National Research University Higher School of Economics and the Centre for Inter-Ethnic Studies in 19 subjects of the Russian Federation. A total of 8,577 respondents were interviewed; 4.5% of them were Azerbaijanis (388 respondents). To assess the integration resources of the Azerbaijani migrants the author examines their status as compared to other migrants and the local population. The study reveals that, unlike Central Asian ethnic groups, Azerbaijanis have more favorable positions in all spheres of social life, and it proves their high integration potential especially in a demanding Russian society. This in turn decreases the importance of their cultural distinctiveness and facilitates further integration and immersion in the local communities.
Acknowledgment. The study was part of the projects carried out by the Centre for Inter-Ethnic Studies of the Institute of Sociology (Russian Academy of Sciences).
Pengaruh pemberian kombinasi minyak rami dengan minyak wijen terhadap kadar kolesterol high density lipoprotein (HDL) pada tikus sprague dawley dislipidemia
Authors: Meisyahputri Bike , Ardiaria Martha 
Published: January 2019

Latar Belakang: Dislipidemia merupakan faktor risiko dari penyakit kardiovaskular (CVD) seperti penyakit jantung koroner (PJK) dan artherosklerosis. Dislipidemia adalah kelainan metabolisme lipid dalam darah. Salah satu kelainan komponen lipid yaitu menurunnya kadar kolesterol High Density Lipoprotein (HDL). Minyak rami dan minyak wijen yang mengandung asam linolenat, asam linoleat dan antioksidan yang berpotensi dalam meningkatkan kadar kolesterol HDL darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kombinasi minyak rami dengan minyak wijen terhadap kadar kolesterol HDL pada tikus dislipdemia.Metode : Penelitian true experimental dengan pre-post test randomized control group design terhadap 24 ekor tikus Sprague dawley dislipidemia dibagi secara acak menjadi 4 kelompok yaitu kelompok kontrol diberikan pakan standar dan tinggi kolesterol dan tiga kelompok perlakuan diberikan pakan tinggi kolesterol dan kombinasi minyak rami dengan minyak wijen dosis 1 ml/200 gBB, 2 ml/200 gBB, 3 ml/200 gBB selama 14 hari. Kadar kolesterol HDL diperiksa dengan metode CHOD-PAP. Data dianalisis dengan uji Paired t-test dan Anova.Hasil : Terdapat perbedaan penurunan kolesterol HDL secara bermakna sebelum dan sesudah perlakuan pada kelompok kontrol sebesar 1,43% (p=0,003). Kelompok P1, P2, P3 mengalami peningkatan kolesterol HDL secara bermakna (p<0,05) berturut-turut yaitu sebesar 18,49% (p=0,000), 29,21% (p=0,000), dan 50,85% (p=0,000).Simpulan : Ketiga kelompok perlakuan dengan pemberian kombinasi minyak rami dengan minyak wijen selama 14 hari terbukti dapat meningkatkan kadar kolesterol HDL. Kelompok perlakuan dosis 3 ml/200 gBB paling efektif meningkatkan kolesterol HDL pada tikus dislipidemia.
Konsumsi fast food dan aktivitas fisik sebagai faktor risiko kejadian overweight pada remaja stunting SMP
Authors: Bonita Ika Amalina , Fitranti Deny Yudi 
Published: January 2019

Latar Belakang: Anak stunting pada usia sekolah dapat berisiko 3 kali menjadi remaja obesitas. Kejadian overweight pada anak stunting disebabkan karena adanya perubahan pola makan dan aktifitas fisik. Konsumsi fast food lebih dari 2 kali seminggu dan aktivitas fisik yang rendah cenderung meningkatkan kejadian overweight pada remaja.Tujuan: Mengetahui konsumsi fast food dan aktivitas fisik sebagai faktor risiko kejadian overweight pada remaja stunting SMP.Metode: Penelitian ini merupakan penelitian observasional dengan desain case control. Pengambilan sampel dilakukan dengan consecutive sampling. Subjek penelitian terdiri dari 23 kelompok kasus (stunting overweight) dan 23 kelompok kontrol (stunting non overweight). Kriteria stunting menggunakan indikator TB/U sedangkan kriteria overweight menggunakan indikator IMT/U. Data frekuensi konsumsi makanan, asupan energi, lemak, natrium, dan serat diperoleh melalui formulir FFQ semi kuantitatif dan aktivitas fisik menggunakan kuesioner PAQ-A. Data tinggi badan diukur menggunakan microtoise sedangkan berat badan menggunakan timbangan digital.Hasil: Frekuensi konsumsi western fast food (OR= 8,7 (95%CI: 1,9-37,5), total energi fast food (OR= 3,5 (95%CI: 1,1-11,8), total lemak western fast food (OR= 4,3(95%CI: 1,3-14,7), dan total natrium fast food (OR= 3,5 (95%CI: 1,1-11,8) merupakan faktor risiko kejadian overweight pada remaja stunting (p < 0,05).Simpulan: Frekuensi konsumsi western fast food, total energi fast food, total lemak western fast food, dan total natrium fast food merupakan faktor risiko kejadian overweight pada remaja stunting.
Hubungan konsumsi cairan dengan status hidrasi pekerja di suhu lingkungan dingin
Authors: Suprabaningrum Annisa Ratih , Dieny Fillah Fithra 
Published: January 2019

Latar Belakang: Pekerja indoor yang telah terpapar suhu dingin dalam waktu yang lama berpotensi mengalami dehidrasi karena ketidakcukupan asupan air akibat kurangnya kepekaan rasa haus serta pengeluaran air melalui urine dan sebagian lainnya melalui kulit dan pernapasan. Namun belum banyak penelitian yang melaporkan hal tersebut. Tujuan penelitian ini untuk menganalisis hubungan konsumsi cairan dengan status hidrasi pada pekerja di lingkungan dingin.Metode: Penelitian Observasional dengan desain cross sectional, bertempat di PT Kompas Gramedia Semarang dengan jumlah sampel 34 subjek yang dipilih dengan simple random sampling. Data yang dikumpulkan meliputi karakteristik subjek, suhu lingkungan kerja, konsumsi cairan, gejala dehidrasi, dan status hidrasi. Konsumsi cairan diukur dengan menggunakan recall selama 1x24 jam dan status hidrasi diketahui dengan pemeriksaan berat jenis urin. Gejala dehidrasi diukur dengan kuesioner.Hasil: Pada penelitian ini ditemukan sebanyak 44.1% pekerja mengonsumsi cairan kurang dari 2500 ml/hari dan 55.9 % mengonsumsi cairan 2500-4000 ml/hari (rerata total konsumsi cairan 2538.30 ± 456.01 ml dan kebutuhan cairan 2500-4000 ml). Sebanyak 67.6 % pekerja yang memiliki status hidrasi baik. Sisanya ditemukan mengalami dehidrasi ringan 32.4 %. Terdapat hubungan signifikan antara konsumsi cairan dengan status hidrasi pada pekerja di suhu lingkungan dingin ( p = 0,001).Simpulan: Terdapat hubungan konsumsi cairan dengan status hidrasi pada pekerja di lingkungan dingin.
FAKTOR DETERMINAN JUMLAH KONSUMSI SOFT DRINK PER HARI PADA ANAK USIA 10-12 TAHUN DI PEDESAAN
Authors: Dewi Clara Rashinta , Subagio Hertanto Wahyu , Panunggal Binar 
Published: January 2019

Background: Children become consumer target of soft drink. Many factors influencing children’s consumption of soft drink. There are only few studies about factor influencing children’s consumption in rural area. Objective : To analyze total soft drink consumption per day among 10-12 year-old children in rural area and analyze determinant factors of soft drink consumption.Methods : Cross-sectional study design in 109 children aged 10-12 years who was selected by consecutive sampling. Data collected were gender, nutrition knowledge related soft drink, attitude to soft drink consumption,, pocket money, peer influence, and exposure to mass media. The instruments used are questionnaire and Semi Quantitative Food Frequency Questionaire (SQ-FFQ). Data were analyze using rank Spearman test and Chi Square test.Result : Total soft drink consumption per day was 422,0±483,94ml. Variables that correlated with total soft drink consumption per day were gender (p=0,025), attitude to soft drink consumption (r=0,28;p=0,003) and peer influence (r=0,25;p=0,007). Variables that are not correlated with total soft drink consumption per day were nutrition knowledge (r=-0,10;p=0,269), pocket money (r=-0,10;p=0,265), exposure to mass media (r=0,15;p=0,116).Conclusion : Factors that correlated with total soft drink consumption per day were gender (p=0,025), attitude to soft drink consumption (r=0,28;p=0,003) and peer influence (r=0,25;p=0,007).
Sex assignment practice in disorders of sexual differentiation: survey results from paediatric endocrinologists in the Arab region
Authors: Deeb Asma , Khamis Maryam , Sayed Shayma Al , Magdy Omar Omneya , Odeh Rasha , Ladjouze Asmahane , Ameri Elham Al 
Published: January 2019

Abstract

Background
Sex assignment is a major issue in disorders of sexual differentiation (DSD). Not all conditions of DSD have clear recommendations on assignment and timing of surgery. Reports about sex assignment practice and the influence of culture and religion in the Arab region are scarce.

Methods
A survey questionnaire was distributed to participants in a paediatric endocrinology conference. Four DSD cases were presented. Participants were asked to fill in their answers on sex assignment choice, reasons for the particular assignment, strength of own recommendation and timing of surgery based on their practice. The cases presented were severely virilised XX congenital adrenal hyperplasia (CAH), complete androgen insensitivity syndrome (CAIS), severely undervirilised 5α reductase deficiency (5α RD) and XX ovotesticular case.

Results
Eighty-five endocrinologists participated in the study. Eighty (97.5%) chose a female sex to assign for the XX CAH. For the CAIS, 64 (78%) chose a female sex. Seventy-one (86.5%) voted for a male sex for the XY case of 5α RD. Forty-seven (57%) and 35 (43%) chose a female and a male sex for the ovotesticular case, respectively. The majority indicated that their advice for sex assignment is based on strong recommendations for the CAH, CAIS and 5α RD patients but they were open to the parents’ cultural and religious beliefs in their decision of the assignment for the ovotesticular case.

Conclusions
Practice in the Arab region appears to be in line with the international guidelines in the majority of DSD sex assignment and timing of surgery issues. However, culture and religious beliefs influence the practice in certain circumstances.