bluuebunny/crossref_metadata_2025_split huggingface dataset:
ETHANOL EXTRACT AND ACTIVE FRACTION EFFECT OF Moringa Oleifera. Lam IN INHIBITING COX-2 ACTIVITY ON MCF-7 CELL
Authors: D Azizah , K Masfria , AZH. Poppy 
Published: November 2018

The expression of COX-2 is involved in carcinogenesis through the proliferative process, angiogenesis and inhibition of apoptosis. Moringa oleifera has been shown to function as an anti-oxidant, anti-inflammatory, anti-microbial and anticancer. Moringa leaf extraction was done by percolation method, and continued to liquid-liquid extraction to obtain nonpolar, semipolar, and polar fractions using n-hexane and ethylacetate solvent.The aim of this study was to determine the effect of ethanol extract and the fraction of n-Hexane of Moringa oleifera leaf in decreased MCF-7 breast cancer cell and COX-2 expression. This study used true experimentation in vitro design using MCF-7 cells. MTT Assay was performed using a therapeutic dose 6,125-1000 μg / ml to determine IC50 in MCF-7 cells. IC50 of ethanol extract was obtained 94.44 μg / ml and 97.60 μg / ml for n-Hexane fraction. Selectivity index of both samples was 3.95 μg / ml and 2.87 μg / ml. The expression of COX-2 was tested qualitatively with immunocytochemical methods and showed that ethanol extract and n-hexane fraction of Moringa oleifera leaf were able to suppress COX-2 enzyme expression on MCF-7 cells depending on concentration.
Keywords: Moringa leaf, cancer cells MCF-7, Apoptosis and COX-2
Anti-arthritic Evaluation of Different Extracts of Boerhaavia diffusa Linn. in FCA Induced Arthritis In Rats
Authors: Parmar Deepika , Jain Neetesh Kumar , Tomar Vivek 
Published: November 2018

The main aim of study is to evaluate the anti-arthritic effect of different extracts of Boerhaavia diffusa in arthritic rats. Different extracts were prepared by successive solvent extraction methods by using the various polar and non polar solvents and their % yields were calculated. Arthritis was induced by FCA induced arthritis model in rats and paw volume was measured on different days. Body weights of all animals were also measured simultaneously and at the end of experiment some haematological parameters were measured. On preliminary phytochemical studies extracts showed the presence of alkaloids, fatty acids, terpenoids, flavonoids and phenolic compounds. Among all extracts, methanolic extract significantly decreased the paw volume in all treated groups. Methanolic extracts also restored the body weight significantly. The results of our study revealed that all the extracts treated group’s causes significant alterations in the hematological parameters and maximal effects were observed at 400 mg/kg. Since methanolic extract showed best activity in arthritic model and its phytochemical study showed presence of flavonoids and phenolic compounds, so it may be possible that anti-arthritic activity of root extracts may be due to presence flavonoids.
Keywords: Arthritis, FCA induced arthritis, Boerhaavia diffusa, haematological parameters, and Body weight
FLOATING TABLETS AND ITS POLYMERS
Authors: Zubedi Shaika Saadia , Mohammed Shahid 
Published: November 2018

Oral drug delivery system is the most preferred route of administration for drug delivery. In the development of the drug delivery system many components play important role. Polymers are amongst those components which have evolved with the drug delivery system. Polymers are the macromolecule compound containing many monomer units joined to each other by bonds. The floating drug delivery systems (FDDS) become an additional advantage for drugs that are absorbed primarily in the upper segments of gastrointestinal (GI) tract, i.e., the stomach, duodenum and jejunum. The purpose of writing this review on floating drug delivery systems (FDDS) was to focus on the types of floating drug delivery systems, principal and mechanism of floatation to achieve gastric retention and polymers used in floating Drug delivery systems. Polymers used in the drug delivery system are of two types Natural and Synthetic based on their origin. Both types of the polymers have some advantages and disadvantages. This particular article gives information about the different types of natural and synthetic polymer used in the drug delivery system. Natural polymers like guar gum, chitosan, xanthan gum, Gellan gum and sodium alginate are mentioned in the article. Synthetic polymers mentioned are HPMC, Eudragit, and Ethylcellulose.
Keywords: Floating Drug Delivery System, Polymers, Natural gums, HPMC.
REVIEW ON A POTENTIAL OF ANTIBIOTICS
Authors: Singh Pawan , Verma Navneet , Kumar Prevesh , Nagu Priynaka 
Published: November 2018

Observations about the growth of some microorganisms inhibiting the growth of other microorganisms have been reported since the late 1800s. These observations of antibiosis between microorganisms led to the discovery of natural antibacterial. This paper deliberates important findings of the educations conducted by numerous national and international combined organizations on a brief indication of the antibacterial agents׳ detection in recent years. In India especially the developing antibiotics, need to institute methods for the suitable choice of drug conduct a compound problem involving prescribers, dispensers, and consumers.
Keywords: Antibiotic, Antibiotic resistance, bacterial Infection
REVIEW ON NOVEL OSMOTIC DRUG DELIVERY SYSTEM
Authors: Bansode AS , Sarvanan K 
Published: November 2018

Novel drug delivery systems (NDDS) are the key area of pharmaceutical research and Development. The reason is relatively low development cost and time required for introducing a NDDS as compared to new chemical entity. Many conventional drug delivery systems have been designed to modulate the release a drug over an extended period of a time. Various designs are available to control or modulate the drug release from a dosage forms. Majority of oral CR dosage forms fall in the category of matrix, reservoir or osmotic systems. Osmotically controlled drug delivery systems (OCDDS) is one of the most promising drug delivery technology that use osmotic pressure as a driving force for controlled delivery of active agents. Drug release from OCDDS is independent of pH and hydrodynamic conditions of the body because of the semipermeable nature of the Rate controlling membrane and the design of deliver orifice used in osmotic systems, so a high degree of In vitro/In vivo correlation is achieved. Osmotic drug delivery systems release the drug with the zero order kinetics which does not depend on the initial concentration and the physiological factors of GIT. This review brings out new technologies, fabrication and recent clinical research in osmotic drug delivery.
Keywords: Osmotic, Matrix, Reservoir, Fabrication
Manticore: análise do processo de criação de ma graphic novel
Authors: Oliveira Ivan Carlo Andrade de 
Published: November 2018

O artigo analisa o processo de criação da graphic novel Manticore e aborda a criação de personagens, os ganchos e o suspense. Também é discutida a questão da forma do texto nos quadrinhos e sua relação com a imagem sob uma perspectiva da teoria da informação.
Editores
Authors: Editores Editores- 
Published: November 2018

EditoresEditor Científico:Prof. Dr. Cresus Vinicius Depes de Gouvea - UFFEditor Chefe:Prof.Dr. Marcos da Veiga Kalil - UFFConselho editorial:Prof.ª Dr.ªANa Maria Gondim Valença - UFPBProf. Dr. Cresus Vinicius Depes de Gouvêa - UFFProf.ª Dr.ª Cristiane Salgado de Souza - UFSProf.ª. Dr.ª Eliane dos Santos Porto Barbosa - UFFProf. Dr. Elson Comark - UFRJProf.ª Dr.ªHilda Mª Montes R. de Souza - UERJProf.ª Dr.ª Ivone de Oliveira Salgado - UFJFProf. Dr. José Galba Menezes Gomes - UNIFORProf.Dr. José Luiz Lage Marques - USPProf. Dr. José Nelson Mucha - UFFProf. Dr. José Thadeu Pinheiro - UFPEProf.Dr. Pedro Gregol da Silva - UFMSProf. Dr. Ricardo Carvalhaes Fraga - UFFProf. Dr. Sergio Kahn - FESOProf. Dr. Vicente De Paulo Aragão - UFCEProf. Dr. Helio Rogrigues Sampaio Filho - - UERJ/UNIFESO/UVAProf. Dr. Luiz Alexandre M. S. Sassone - UERJ/UGFProf. Dr. Marcelo Mangelli Decnop Batista - UGFAssistenteEditorial:Prof. Dr. Gustavo André de Deus Carneiro Vianna - UFFProf. Dr.Gutemberg Heleno - UFFEditores Associados:Prof. Dr.Aldair Stefanello Busato - ULBRAProf.Dr.Fernando Monteiro Aarestrup - UFJFProf.Dr.Sigmar de Mello Rode - UNESPProf.Dr.José Mauro Grangeiro - UFFEditora Ad hoc:Prof.ª Dr.ªMônica Diuana Calazans Maia - UFFEditor de LayoutProf.Gustavo Vicentis de Oliveira Fernandes AssistenteTécnico em InformáticaHélder Nascimento da Silva - UFF
Editores
Authors: Admin Admin 
Published: November 2018

Editor Científico: Prof. Dr. Cresus Vinicius Depes de Gouvea - UFF Editor Chefe: ​ Prof.Dr. Marcos da Veiga Kalil - UFF Conselho editorial: Prof.ª Dr.ªANa Maria Gondim Valença - UFPB Prof. Dr. Cresus Vinicius Depes de Gouvêa - UFF Prof.ª Dr.ª Cristiane Salgado de Souza - UFS Prof.ª. Dr.ª Eliane dos Santos Porto Barbosa - UFF Prof. Dr. Elson Comark - UFRJ Prof.Dr. Fernando Monteiro Aarestrup -UFJF Prof.ª Dr.ªHilda Mª Montes R. de Souza - UERJ Prof.ª Dr.ª Ivone de Oliveira Salgado - UFJF Prof.Dr. José Luiz Lage Marques - USP Prof. Dr. José Nelson Mucha - UFF Prof. Dr. José Thadeu Pinheiro - UFPE Prof.Dr. Pedro Gregol da Silva - UFMS Prof. Dr. Ricardo Carvalhaes Fraga - UFF Prof.Dr. Sigmar de Mello Rode - UNESP Prof. Dr. Sergio Kahn - FESO Prof. Dr. Vicente De Paulo Aragão - UFCE Prof. Dr. Helio Rogrigues Sampaio Filho - - UERJ/UNIFESO/UVA Prof. Dr. Luiz Alexandre M. S. Sassone - UERJ/UGF Profª.Dr.ª Luciana Moura Sassone – UERJ/UGF Prof. Dr. Marcelo Mangelli Decnop Batista - UGF
Tratamento clínico-cirúrgico de lesão endodôntico-periodontal: relato de caso.
Authors: Beatriz Mourão Oliveira Anna 
Published: November 2018

O presente trabalho tem como objetivo apresentar a conduta clínica e cirúrgica, com acompanhamento clínico e radiográfico, de lesão com envolvimento endodôntico e periodontal no dente 36. Paciente do gênero feminino, 23 anos, em bom estado de saúde, apresentava drenagem espontânea no sulco gengival vestibular do dente 36, com resposta negativa ao teste de sensibilidade pulpar ao frio, sugerindo necrose pulpar. Ao exame clínico, o dente apresentava-se com mobilidade, sondagem periodontal com mais de 10 mm de penetração, além de restauração de resina composta na face oclusal. Ao exame radiográfico, observou-se extensa área de perda óssea na região de furca com radiolucidez também na região periapical. Foi procedido o acesso coronário com localização de 4 canais e preparo químico-mecânico com modelagem apical final em 30.05 (Limas NiTi Easy Prodesign) acompanhado de irrigação com solução de hipoclorito de sódio a 6% e EDTA a 17%. Como medicação intracanal, foi utilizada pasta a base de hidróxido de cálcio e paramonoclorofenol canforado (Calen PMCC) por 15 dias. Após esse período, persistia a drenagem da secreção pelo periodonto, quando optou-se pela cirurgia exploratória e de raspagem. Todo o tecido inflamatório foi removido, e a região foi medicada com tetraciclina aplicada no local por 15 minutos. Em seguida, a tetracicilna foi removida com soro fisiológico e o retalho suturado. Decorridos 7 dias da cirurgia, a secreção já havia cessado. O dente foi reaberto para remoção da medicação intracanal e irrigado com hipoclorito de sódio a 6% e EDTA a 17%. Foi realizada a obturação por compressão vertical da guta-percha termoplastificada e cimento Endofill, e a cavidade de acesso foi restaurada com resina composta. Proservação clínica e radiográfica aos 4, 7, 10 e 22 meses após o tratamento mostram a evolução da recomposição total do periodonto, evidenciando o sucesso da terapia.
Controlling In Vivo, Human Pulp Temperature Rise Caused by LED Curing Light Exposure
Authors: Zarpellon DC , Runnacles P , Maucoski C , Coelho U , Rueggeberg FA , Arrais CAG 
Published: November 2018

SUMMARY

Objective:
The objective of this study was to evaluate the in vivo effectiveness of air spray to reduce pulp temperature rise during exposure of intact premolars to light emitted by a high-power LED light-curing unit (LCU).

Methods and Materials:
After local Ethics Committee approval (#255945), intact, upper first premolars requiring extraction for orthodontic reasons from five volunteers received infiltrative and intraligamental anesthesia. The teeth (n=9) were isolated using rubber dam, and a minute pulp exposure was attained. The sterile probe from a wireless, NIST-traceable, temperature acquisition system was inserted directly into the coronal pulp chamber. Real-time pulp temperature (PT) (°C) was continuously monitored, while the buccal surface was exposed to a polywave LED LCU (Bluephase 20i, Ivoclar Vivadent) for 30 seconds with simultaneous application of a lingually directed air spray (30s-H/AIR) or without (30s-H), with a seven-minute span between each exposure. Peak PT values were subjected to one-way, repeated-measures analysis of variance, and PT change from baseline (ΔT) during exposure was subjected to paired Student's t-test (α=0.05).

Results:
Peak PT values of the 30s-H group were significantly higher than those of 30s-H/AIR group and those from baseline temperature (p&lt;0.001), whereas peak PT values in the 30s-H/AIR group were significantly lower than the baseline temperature (p=0.003). The 30s-H/AIR group showed significantly lower ΔT values than did the 30s-H group (p&lt;0.001).

Conclusion:
Applying air flow simultaneously with LED exposure prevents in vivo pulp temperature rise.
Surface Sealant Effect on the Color Stability of a Composite Resin Following Ultraviolet Light Artificial Aging
Authors: Brooksbank A , Owens BM , Phebus JG , Blen BJ , Wasson W 
Published: November 2018

SUMMARY

Objective:
To examine how exposure to accelerated artificial aging (AAA) stimuli (ultraviolet [UV] light) affects the color stability of a composite resin following surface sealant (SS) application.

Methods and Materials:
A total of 30 cylindrical composite resin (Esthet-X) discs were prepared using Teflon-coated rings. The treatment groups, defined by different SS (Seal-N-Sine, PermaSeal, OptiGuard, Biscover LV, and DuraFinish) use, were divided into five groups of six discs each. The discs were subjected to baseline color measurements followed by measurements after surface sealant application (specular included component [SCI] and specular excluded component [SCE]) using a spectrophotometer. Three measurements (SCI and SCE) were performed for a total of 18 readings (test surface) per specimen group. All specimens were then exposed to a UV light source for a total of 382 hours. Color readings of the specimens were again recorded for each group. Quantitative color measurements were executed using Commission Internationale de l'Eclairage L*a*b* calculations.

Results:
Baseline color measurements of the composite resin discs, following the AAA exposure protocol, revealed no significant differences. A comparison of the composite resin discs before and after SS application (without UV light exposure) showed statistically significant differences using both SCI and SCE measurement criteria. Although significant differences were encountered between the ΔL*, Δa*, Δb*, and ΔE parameters, all specimens (groups) were within the clinically acceptable range (1.0&lt;ΔE≤ 3.3). Again, statistically significant differences were noted (ΔL*, Δa*, Δb*, and ΔE parameters) for all specimen groups receiving SS application, utilizing both SCI and SCE measurements, following exposure to UV light. All groups were within the clinically acceptable range (1.0&lt;ΔE≤ 3.3), except the Durafinish group. The Durafinish SS group experienced significantly greater (p&lt;0.001) overall color change (SCI and SCE) following UV light exposure. An intergroup comparison following UV exposure revealed that the Permaseal, OptiGuard, and Seal-n-Shine SS groups displayed the least amount of color change statistically but not necessarily always perceptibly significant, while the Durafinish group exhibited the greatest color change statistically and perceptibly.

Conclusions:
The color stability of a composite resin, including the addition of most SSs, was not affected perceptibly by UV light exposure.
Observations on the consumption and dispersal of Phoenix canariensis drupes by the Grey-headed flying-fox (Pteropus poliocephalus)
Authors: Spennemann Dirk 
Published: November 2018

Abstract
Aided by their transplantability as adult plants, Phoenix canariensis and Washingtonia robusta palms have a long history as ornamental feature trees in urban settings. With their plentiful production of carbo-hydrate reach drupes, palms have become a major food source for the grey-headed flying-fox (Pteropus poliocephalus) during late autumn and early winter. This paper reviews the consumption of Phoenix canariensis and Washingtonia robusta drupes based on the field observations and a morphological and metric analysis of spat-out remains (‘ejecta’). Based on a review of the mastication mechanics of fruit consumption, the paper demonstrates that P. poliocephalus can be ruled out as a disperser of the invasive Phoenix canariensis, but must be considered for the dispersal of Washingtonia robusta.
José Clemente Orozco, Caricaturista
Authors: Rashkin Elissa J. 
Published: November 2018

José Clemente Orozco es conocido sobre todo por sus murales, pero su trabajo como caricaturista, oficio que ejerció durante décadas, ha tenido poca difusión. De ahí la importancia de la exposición "José Clemente Orozco: obra gráfica", presentada en 2017 en Xalapa y en el Puerto de Veracruz, que reunió 67 piezas de las 234 que resguarda el acervo del Instituto Veracruzano de la Cultura (Ivec). En ellas satiriza la hipocresía del amor romántico y el matrimonio, la infidelidad, la coquetería femenina, la violencia doméstica, la moral de los clérigos, los embarazos vergonzosos y las mentiras que la sociedad "decente" defendía. Muchas de esas caricaturas fueron publicadas por el diario orizabeño La Vanguardia en 1915.
Eigencages: Learning a Latent Space of Porous Cage Molecules
Authors: Sturluson Arni , Huynh Melanie T. , York Arthur H. P. , Simon Cory 
Published: November 2018

Porous organic cage molecules harbor nano-sized cavities that can selectively adsorb gas molecules, lending them applications in separations and sensing. The geometry ofthe cavity strongly influences their adsorptive selectivity. For comparing cages and predicting their adsorption properties, we embed/encode a set of 74 porous organiccage molecules into a low-dimensional, latent “cage space” on the basis of their intrinsic porosity. We first computationally scan each cage to generate a 3D image of its porosity. Leveraging the singular value decomposition, in an unsupervised manner, we then learn across all cages an approximate, lower-dimensional subspace in which the 3D porosity images lay. The “eigencages” are the set of orthogonal characteristic 3D porosity images that span this lower-dimensional subspace, ordered in terms of importance. A latent representation/encoding of each cage follows from expressing it as a combination of the eigencages. We show that the learned encoding captures salient features of the cavities of porous cages and is predictive of properties of the cages that arise from cavity shape.
Penggunaan Virtual Laboratory berbasis PhET Simulation Untuk Menentukan Konstanta Wien
Authors: Astuti Irnin Agustina Dwi , Handayani Santy 
Published: November 2018

Penelitian ini bertujuan untuk menentukan nilai konstanta Wien dengan menggunakan virtual laboratory yaitu PhET Simulation. PhET merupakan rangkaian simulasi interaktif yang sangat menguntungkan dalam pengintegrasian teknologi komputer ke dalam pembelajaran atau eksperimen. Alat dan bahan yang digunakan pada eksperimen ini diantaranya yaitu laptop dan software PhET Simulation. Metode yang digunakan dalam analisis data adalah dengan analisis regresi liniear yaitu hubungan antara panjang gelombang dengan suhu. Semakin tinggi suhu maka panjang gelombangnya semakin kecil. Nilai konstanta Wien yang diperoleh sebesar 0,003 mK, dengan ralat relatif sebesar 3,4 %. Hal ini mendekati dengan nilai teori yaitu 0,029 mK dan membuktikan bahwa dengan menggunakan PhET Simulation sangat efektif untuk analisis eksperimen.
Perencanaan Pengelolaan Sampah di Pondok Pesantren Langitan Kecamatan Widang Tuban
Authors: Auvaria Shinfi Wazna 
Published: November 2018

Pondok Pesantren merupakan salah satu institusi pendidikan islam yang sering identik dengan kurangnya manajemen lingkungan di dalamnya, terutama pengelolaan sampahnya. Pondok Pesantren Langitan dengan jumlah 3000 santri dengan wilayah seluas 7 hektar, menghasilkan sampah tidak kurang dari 400 kg/hari. Pengelolaan sampah masih dilakukan secara tradisional yaitu dikumpulkan, dikeringkan, dan dibakar. Belum adanya pemilahan pada sistem pewadahan dan pengumpulan, serta belum adanya kegiatan pengolahan sampah terpadu di tempat penampungan sampah sementara.Oleh karena itu dibutuhkan pengelolaan sampah sederhana yang paling mungkin dilaksanakan di pondok pesantren. Pengelolaan sampah berkelanjutan yang dibutuhkan meliputi pewadahan, pengumpulan, dan pengolahan sampah untuk menangani timbulan sampah. Perencanaan sistem pewadahan, pengumpulan, dan pengolahan dilakukan berdasarkan hasil analisis komposisi dan volume sampah dipondok pesantren dengan teori perempatan, yang disesuaikan dengan persyaratan pada SK SNI T-13-1990-F dan aspek ekonomis. Berat timbulan sampah total 496,66 kg/hari dengan komposisi sampah yang didapatkan terdiri dari sampah organik 49,64% dan sampah anorganik 50,36%. Jumlah keseluruhan wadah sampah yang dibutuhkan dalam perencanaan ini adalah 44 pasang wadah sampah, yang terdiri dari 44 wadah anorganik (kuning) dan 44 wadah organik (biru) dengan pengumpulan sampah 1 trip/hari. Kegiatan pengolahan sampah direncanakan dengan komposting dan sortasi sampah yang dapat didaur ulang. Rencana anggaran biaya dalam perencanaan pengelolaan sampah ini sebesar Rp.16.699.172,00.
Manajemen Proyek dalam Pembangunan Berwawasan Lingkungan Berkelanjutan (Studi Pembangunan Masjid Kampus II FIP Universitas Negeri Malang)
Authors: Prianto Kusnul 
Published: November 2018

Proses manajemen proyek konstruksi dalam pembangunan yang berwawasan lingkungan dapat menjadikan kontrol untuk mewujudkan proses perencanaan, pelaksanaan, maupun pengawasan sesuai dengan tujuan yang diharapkan. Perencanaan merupakan salah satu bagian dari manajemen konstruksi untuk menghasilkan produk rancangan yang berkelanjutan. Proses perencanaan itu sendiri memiliki bagian-bagian tersendiri yang membutuhkan beberapa tenaga ahli untuk merumuskan desain, proses yang terjadi dalam rangkaian kegiatan tersebut tentunya melibatkan banyak pihak, baik secara langsung maupun tidak langsung. Pembangunan berkelanjutan yang berwawasan lingkungan (PBBL) memiliki turunan yaitu dokumen konstruksi Indonesia 2030. Dalam dokumen konstruksi tersebut menyatakan bahwa Indonesia harus berorientasi untuk tidak menyumbangkan kerusakan lingkungan namun harus menjadi pelopor perbaikan dan peningkatan kualitas lingkungan. Pembangunan Masjid kampus II Fakultas Ilmu Pendidikan Universitas Negeri Malang berusaha menerapkan konsep pembangunan yang berwawasan lingkungan. Perencanaan masjid tersebut berusaha untuk sehemat mungkin dalam memakai material yang dapat merusak lingkungan begitu juga pada masa pelaksanaannya. Penggunaan material didalam proses pembangunan masjid kampus II Fakultas Ilmu Pendidikan telah memenuhi kaidah material yang berwawasan lingkungan, mulai dari penggunaan material untuk pekerjaan pengecoran, rangka atap, kusen dan daun pintu, material finishing, infrastruktur penunjang dan pekerjaan sanitasi. Manajemen proyek konstruksi didalam proses perencanaan yang berwawasan lingkungan (berkelanjutan) sangat penting diterapkan terutama untuk menganalisa secara ekonomis terhadap material yang akan digunakan secara jangka panjang terhadap keberlangsungan lingkungan di sekitarnya.