bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer Stem Cell‐Platelet Hybrid Membrane‐Coated Magnetic Nanoparticles for Enhanced Photothermal Therapy of Head and Neck Squamous Cell Carcinoma
Authors: Bu Lin‐Lin , Rao Lang , Yu Guang‐Tao , Chen Lei , Deng Wei‐Wei , Liu Jian‐Feng , Wu Hao , Meng Qian‐Fang , Guo Shi‐Shang , Zhao Xing‐Zhong , Zhang Wen‐Feng , Chen Guojun , Gu Zhen , Liu Wei , Sun Zhi‐Jun 
Published: January 2019

AbstractCell membrane–based nanosystems with desirable characteristics have been studied extensively for many therapeutic applications. However, current research has focused on single cell membrane, and multifunctional fused membrane materials from different membrane types are still rare. Herein, a platelet–cancer stem cell (CSC) hybrid membrane‐coated iron oxide magnetic nanoparticle (MN) {[CSC‐P]MN} is presented for the first time for the enhanced photothermal therapy of head and neck squamous cell carcinoma (HNSCC). Inherited from the original source cells, the platelet membrane shows immune evading ability due to the surface marker comprising a number of “don't eat me” signals, and the CSC membrane has homotypic targeting capabilities due to the specific surface adhesion molecules. The [CSC‐P]MNs possess superior characteristics for immune evasion, active cancer targeting, magnetic resonance imaging, and photothermal therapy. Compared with single cell membrane–coated MNs, [CSC‐P]MNs exhibit prolonged circulation times and enhanced targeting abilities. Moreover, the [CSC‐P]MNs exhibit a superior photothermal ability that provides excellent HNSCC tumor growth inhibition, particularly in an immunocompetent Tgfbr1/Pten conditional double knockout HNSCC mouse model that contains a more complex tumor microenvironment that is similar to the human HNSCC microenvironment. Collectively, this biomimetic multimembrane‐coated nanoplatform may provide enhanced antitumor efficacy in the complex tumor microenvironment.
A Liquid‐Metal‐Enabled Versatile Organic Alkali‐Ion Battery
Authors: Ding Yu , Guo Xuelin , Qian Yumin , Zhang Leyuan , Xue Leigang , Goodenough John B. , Yu Guihua 
Published: January 2019

AbstractDespite the high specific capacity and low redox potential of alkali metals, their practical application as anodes is still limited by the inherent dendrite‐growth problem. The fusible sodium–potassium (Na–K) liquid metal alloy is an alternative that detours this drawback, but the fundamental understanding of charge transport in this binary electroactive alloy anode remains elusive. Here, comprehensive characterization, accompanied with density function theory (DFT) calculations, jointly expound the Na–K anode‐based battery working mechanism. With the organic cathode sodium rhodizonate dibasic (SR) that has negligible selectivity toward cations, the charge carrier is screened by electrolytes due to the selective ionic pathways in the solid electrolyte interphase (SEI). Stable cycling for this Na–K/SR battery is achieved with capacity retention per cycle to be 99.88% as a sodium‐ion battery (SIB) and 99.70% as a potassium‐ion battery (PIB) for over 100 cycles. Benefitting from the flexibility of the liquid metal and the specially designed carbon nanofiber (CNF)/SR layer‐by‐layer cathode, a flexible dendrite‐free alkali‐ion battery is achieved with an ultrahigh areal capacity of 2.1 mAh cm−2. Computation‐guided materials selection, characterization‐supported mechanistic understanding, and self‐validating battery performance collectively promise the prospect of a high‐performance, dendrite‐free, and versatile organic‐based liquid metal battery.
Highly Efficient Semitransparent Organic Solar Cells with Color Rendering Index Approaching 100
Authors: Zhang Jingwen , Xu Guiying , Tao Feng , Zeng Guang , Zhang Moyao , Yang Yang (Michael) , Li Yaowen , Li Yongfang 
Published: January 2019

AbstractNeutral‐colored semitransparent organic solar cells (ST‐OSCs) have attracted considerable attention owing to their unique application in no‐visual‐obstacle building‐integrated photovoltaics. Toward this promising potential application, a synergistic effect is first proposed by employing a dielectric mirror and ternary photoactive layer with near‐infrared absorption to tune the color perception as well as ST‐OSC performance precisely. As a result, a neutral‐color ST‐OSC with high average transmittance of over 21% is successfully constructed, and a remarkable color‐rendering index approaching 100 and high power conversion efficiency (PCE) of 9.37% are simultaneously achieved. To the best of our knowledge, this is the highest PCE reported for neutral‐color ST‐OSCs to date. Importantly, this synergistic effect is demonstrated to be a universal strategy that is not only suitable for various photoactive layer systems, but can also be implanted in flexible substrate. The resulting neutral‐color flexible ST‐OSCs also show a promising PCE of 8.76%.
Ordered Hybrid Micro/Nanostructures and Their Optical Applications
Authors: Wu Yuxin , Zhang Kai , Yang Bai 
Published: January 2019

AbstractRecent advances in manufacturing and technology of ordered hybrid micro/nanostructures have acquired many breakthroughs. With the aid of the cooperation of various materials, the ordered hybrid micro/nanostructures exhibit high‐quality performance and mechanical stability and allow the modulation on the light–matter interaction in a controllable manner, thereby enabling a wide variety of innovative applications. This article reviews recent developments of ordered hybrid micro/nanostructures, with emphasis on the periodic laminar structure, colloidal crystal, and its derivative patterns. Herein, the elegant optical properties derived from structures are mainly referred to. Besides, the fabrication techniques of ordered structures are briefly described. Moreover, an updated overview of the literature on optical application examples of ordered hybrid micro/nanostructures is listed in detail. Finally, the current challenges and directions for future development are elucidated.
The Role of Chloride Incorporation in Lead‐Free 2D Perovskite (BA)2SnI4: Morphology, Photoluminescence, Phase Transition, and Charge Transport
Authors: Wang Jun , Shen Hongzhi , Li Wancai , Wang Shuai , Li Junze , Li Dehui 
Published: January 2019

AbstractThe incorporation of chloride (Cl) into methylammonium lead iodide (MAPbI3) perovskites has attracted much attention because of the significantly improved performance of the MAPbI3‐based optoelectronic devices with a negligible small amount of Cl incorporation. It is expected that the Cl incorporation in 2D perovskites with layered nature would be much more efficient and thus can greatly alter the morphology, optical properties, phase transition, and charge transport; however, studies on those aspects in 2D perovskites remain elusive up to date. Here, a one‐pot solution method to synthesize the Cl‐doped lead‐free 2D perovskite (BA)2SnI4 with various Cl incorporation concentrations is reported and how the Cl incorporation affects the morphology change, photoluminescence, phase transition, and charge transport is investigated. The Cl element is successfully incorporated into the crystal lattice in the solution‐processed perovskite materials, confirmed by X‐ray photoelectron spectroscopy and energy dispersive X‐ray spectroscopy measurements. The temperature‐dependent photoluminescence studies indicate that the emission properties and phase transition behavior in (BA)2SnI4−xClx can be tuned by varying the Cl incorporation concentration. Electrical measurement suggests that the charge transport behavior can also be greatly altered by the Cl doping concentration and the electrical conductivity can be significantly improved under a higher Cl incorporation concentration.
AIE Multinuclear Ir(III) Complexes for Biocompatible Organic Nanoparticles with Highly Enhanced Photodynamic Performance
Authors: Zhang Liping , Li Yuanyuan , Che Weilong , Zhu Dongxia , Li Guangfu , Xie Zhigang , Song Nan , Liu Shi , Tang Ben Zhong , Liu Xingman , Su Zhongmin , Bryce Martin R. 
Published: January 2019

AbstractThe singlet oxygen (1O2) generation ability of a photosensitizer (PS) is pivotal for photodynamic therapy (PDT). Transition metal complexes are effective PSs, owing to their high 1O2 generation ability. However, non‐negligible cellular toxicity, poor biocompatibility, and easy aggregation in water limit their biomedical applications. In this work, a series of red‐emitting aggregation‐induced emission (AIE) Ir(III) complexes containing different numbers of Ir centers (mono‐, di‐, and trinuclear) and the corresponding nanoparticles (NPs) AIE‐NPs, are designed and synthesized. The increase of 1O2 generation ability is in line with the increasing number of Ir centers. Compared with the pure Ir(III) complexes, the corresponding NPs offer multiple advantages: (i) brighter emission; (ii) higher phosphorescence quantum yields; (iii) longer excited lifetime; (iv) higher 1O2 generation ability; (v) better biocompatibility; and (vi) superior cellular uptake. Both in vitro and in vivo experiments corroborate that AIE‐NPs with three iridium centers possess potent cytotoxicity toward cancer cells and effective inhibition of tumor growth. To the best of knowledge, this work is the first example of NPs of multinuclear AIE Ir(III) complexes as PSs for enhanced PDT. This study offers a new method to improve the efficiency of PSs for clinical cancer treatments.
Demand peaks and cost pass‐through: The case of Iran's poultry market
Authors: Zamani Omid , Bittmann Thomas , Loy Jens‐Peter 
Published: January 2019

AbstractThis study employs traditional holidays in Iran as proxies to analyze the impact of periods of peak demand on cost pass‐through in the poultry market. We use weekly wholesale and retail price data for all 30 provinces of Iran from 2010 to 2016. By panel cointegration techniques, we estimate cost pass‐through elasticities and speed of adjustment during periods of peak demand. We find that cost pass‐through elasticities slightly increase; the speed of adjustment in periods of peak demand remains the same, but retail–wholesale margins decrease. Thus, peak demand leads to an increase in retail–wholesale competition similarly observed by Chevalier et al. (2003, Am Econ Rev, 93, 15–37).
Does passion for wine matter? The effects of owner motivation on pricing and quality decisions in emerging US wine regions
Authors: Li Jie , Gómez Miguel I. , Brent Ross R. , Chaddad Fabio R. 
Published: January 2019

AbstractIncreasing the success rate of start‐up wineries and fostering the wine–hospitality‐tourism clusters in emerging wine regions with substantial entrepreneurial activities have attracted considerable attention among public and private stakeholders. Understanding entrepreneur's motivation to enter the industry is crucial to understand winery behaviors and industry dynamics. Some entrepreneurs enter the industry motived by passion for wine whereas others are motived by profits. Differences in motivation may contribute to the high variability in quality and quality‐adjusted prices of wines in emerging wine regions. We used ordinary least square and Tobit regression models to investigate the influence of motivation on winery pricing and quality decisions using data on 700 wines from 102 wineries in emerging US wine regions. We find that passion‐oriented owners produce higher quality wines and set higher quality‐adjusted prices relative to profit‐oriented owners. Recognizing differences in owner motivation is critical to establish appropriate policies to support the development of the wine industry in emerging regions. [EconLit citations: Q13; L83; O25].
Patching the Pathway and Widening the Pipeline: Models for Developing a Diverse Early Childhood Workforce in Chicago
Authors: Zinsser Katherine M. , Main Catherine , Torres Luz , Connor Kate 
Published: January 2019

AbstractWith the growing appreciation of the importance of early learning experiences for children's healthy development, attention to the cultivation and maintenance of a qualified workforce has steadily increased. Such a workforce must have not just the knowledge and skills related to child development and early learning, but also be linguistically and culturally prepared to meet the needs of an increasingly diverse child and family population. To ensure a highly qualified workforce, programs and policymakers must attend to both the “pipeline” through which new early childhood educators (ECEs) enter the workforce and the “pathways” by which ECEs work toward and obtain the necessary education and credentials for different roles within the field. In line with the aims of this special issue, this paper leverages the first‐person account style to describe barriers to and creative solutions for the development of practitioners in low‐resourced communities in Chicago, with the goal of informing practice and policy. We describe three prior and ongoing partnership programs between community‐based organizations and institutions of higher education, each tailored to support a unique population in the ECE pipeline on the pathway for increased educational attainment and credentialing. Each program is grounded in a specific community of Chicago, a diverse city with a sizable population of children raised in non‐English speaking homes. Each program addresses specific needs of the communities they serve, especially around the recruitment, retention, and promotion of bilingual ECEs. Program administrators and community members describe each programs’ goals, development, and key components unique to their target population as well as key takeaways. We conclude with an overview of critical components that we identified across these programs in order to create pathways for change within the workforce and the communities they serve.
Template‐Free Synthesis of Highly b‐Oriented MFI‐Type Zeolite Thin Films by Seeded Secondary Growth
Authors: Banihashemi Fateme , Ibrahim Amr F. M. , Babaluo Ali Akbar , Lin Jerry Y. S. 
Published: January 2019

AbstractHighly b‐oriented, closely packed, MFI zeolite films are prepared on seeded stainless‐steel plates using organic template‐free, secondary growth solutions, containing aluminum sulfate as a crystallization agent. The number of a‐oriented twin crystals is significantly reduced, and even eliminated, simply by restricting the pH value of the secondary growth solution to the narrow range of 11.1–11.3. Values of pH can be adjusted through the controlled addition of (NH4)2SO4 or H2SO4 to secondary growth solutions of the composition (1 SiO2:0.57 NaOH:137.5 H2O:0.0050 (Al2(SO4)3⋅18 H2O)) or by simply decreasing the molar composition of NaOH with no extra additives.
Efficient Electrocatalysis for the Preparation of (Hetero)aryl Chlorides and Vinyl Chloride with 1,2‐Dichloroethane
Authors: Liang Yujie , Lin Fengguirong , Adeli Yeerlan , Jin Rui , Jiao Ning 
Published: January 2019

AbstractAlthough the application of 1,2‐dichloroethane (DCE) as a chlorinating reagent in organic synthesis with the concomitant release of vinyl chloride as a useful byproduct is a fantastic idea, it still presents a tremendous challenge and has not yet been achieved because of the harsh dehydrochlorination conditions and the sluggish C−H chlorination process. Here we report a bifunctional electrocatalysis strategy for the catalytic dehydrochlorination of DCE at the cathode simultaneously with anodic oxidative aromatic chlorination using the released HCl as the chloride source for the efficient synthesis of value‐added (hetero)aryl chlorides. The mildness and practicality of the protocol was further demonstrated by the efficient late‐stage chlorination of bioactive molecules.
Palladium‐Catalyzed Asymmetric Intramolecular Reductive Heck Desymmetrization of Cyclopentenes: Access to Chiral Bicyclo[3.2.1]octanes
Authors: Yuan Zhenbo , Feng Ziwen , Zeng Yuye , Zhao Xiaobin , Lin Aijun , Yao Hequan 
Published: January 2019

AbstractA palladium‐catalyzed asymmetric reductive Heck reaction of unactivated aliphatic alkenes, with eliminable β‐hydrogen atoms, has been realized for the first time. A series of optically active bicyclo[3.2.1]octanes bearing chiral quaternary and tertiary carbon stereocenters were obtained in good yields with excellent enantioselectivities, exhibiting good functional‐group tolerance and scalability. Moreover, deuterated optically active bicyclo[3.2.1]octanes were also obtained in high efficiency.
Trapping of a Highly Reactive Oxoiron(IV) Complex in the Catalytic Epoxidation of Olefins by Hydrogen Peroxide
Authors: Engelmann Xenia , Malik Deesha D. , Corona Teresa , Warm Katrin , Farquhar Erik R. , Swart Marcel , Nam Wonwoo , Ray Kallol 
Published: January 2019

AbstractThe generation of a nonheme oxoiron(IV) intermediate, [(cyclam)FeIV(O)(CH3CN)]2+ (2; cyclam=1,4,8,11‐tetraazacyclotetradecane), is reported in the reactions of [(cyclam)FeII]2+ with aqueous hydrogen peroxide (H2O2) or a soluble iodosylbenzene (sPhIO) as a rare example of an oxoiron(IV) species that shows a preference for epoxidation over allylic oxidation in the oxidation of cyclohexene. Complex 2 is kinetically and catalytically competent to perform the epoxidation of olefins with high stereo‐ and regioselectivity. More importantly, 2 is likely to be the reactive intermediate involved in the catalytic epoxidation of olefins by [(cyclam)FeII]2+ and H2O2. In spite of the predominance of the oxoiron(IV) cores in biology, the present study is a rare example of high‐yield isolation and spectroscopic characterization of a catalytically relevant oxoiron(IV) intermediate in chemical oxidation reactions.
Effect of Ca2+ on viscosity and microstructure of water‐soluble triblock terpolymer used as thicker in the hydraulic fracturing
Authors: Chen Ruiyang , Wang Shibin , Shen Xin , Zhao Feng , Guo Jianchun 
Published: January 2019

ABSTRACTCa2+ tolerance of water‐soluble polyacrylamide is a key problem in application fields. It is urgent to make the mechanism of between the polyacrylamide and Ca2+ clear. A terpolymer polyacrylamides including the sulfonate group with different monomer concentrations is synthesized. The effect of the CaCl2 concentration on the rheological properties is measured by a rheological rheometer. The zeta potential of the copolymer solution is obtained by a zeta potentiometer to learn about the electrical characteristics of the copolymers in solution. The microcosmic shape of the copolymer aqueous solution is investigated by a laser particle analyzer and an environmental scanning electron microscope. The results show that more sulfonate groups on the molecule can enhance the salt tolerance of the polyacrylamide. Sulfonate groups can weaken the effect of Ca2+ on the copolymer through the formation of complexes, whereas the self‐aggregation process of the copolymer cannot be stopped at high Ca2+ concentrations. This study provides theoretical guidance to elucidate the influencing rules and mechanism of calcium salt on the polyacrylamide containing a sulfonate group, which can be helpful for polyacrylamide modification and can improve the application of polyacrylamide under the condition of higher salt concentration. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47539.
Common bottlenose dolphin (Tursiops truncatus) abundance and distribution patterns in St Andrew Bay, Florida, USA
Authors: Balmer Brian , Watwood Stephanie , Quigley Brian , Speakman Todd , Barry Kevin , Mullin Keith , Rosel Patricia , Sinclair Carrie , Zolman Eric , Schwacke Lori 
Published: January 2019

Abstract

Common bottlenose dolphins (Tursiops truncatus) are found in temperate and tropical waters of the world across a wide range of habitats. Along Florida's north‐western coast, this species resides in the bays, sounds, and estuaries (BSE) and coastal (CST) waters of the northern Gulf of Mexico. The National Marine Fisheries Service has identified one CST (Northern Coastal Stock) and seven adjacent BSE dolphin stocks, including the St Andrew Bay BSE Stock.
Baseline data are critical to assess the impacts of ongoing and future anthropogenic stressors on these stocks. Currently, there is no comprehensive abundance estimate for the St Andrew Bay BSE Stock, and there are limited data on distribution patterns and site fidelity for this stock. In addition, little is known about the Northern Coastal Stock hypothesized to range from the Big Bend of Florida to the Mississippi River Delta, inclusive of the CST waters adjacent to St Andrew Bay.
The goals of this study were to conduct photographic‐identification surveys during 2015 and 2016 to determine abundance, distribution, and site fidelity of common bottlenose dolphins in the St Andrew Bay BSE Stock over four primary periods (July and October 2015, and April and October 2016).
St Andrew Bay BSE dolphin abundance was lowest in April 2016 (199, 95% confidence interval [CI] 173–246), followed by July 2015 (249, 95% CI 199–338), and highest in October 2015 (299, 95% CI 259–361) and October 2016 (315, 95% CI 274–378). Few individuals were sighted in both BSE and CST waters (N = 25/353; 7%), and this fact, taken in tandem with limited connections between the BSE and CST environments, suggests that there may be minimal overlap between the St Andrew Bay BSE and Northern Coastal Stocks.
Ursolic acid: Pharmacokinetics process in vitro and in vivo, a mini review
Authors: Jinhua Wen 
Published: January 2019

AbstractUrsolic acid (UA) is a natural triterpene compound found in various fruits and vegetables. UA has a widespread pharmacologic effect, including antitumor, anti‐inflammatory, anti‐oxidant, anti‐apoptotic, anti‐allergy, and anti‐carcinogenic effects. UA can be used as an alternative medicine for the treatment and prevention of many diseases. However, the bioavailability of UA by oral administration is low since it is absorbed by the intestine through passive diffusion. Therefore, some novel technologies are used to produce UA preparations that can change the pharmacokinetics process and increase its solubility and bioavailability. At present, pharmacokinetic studies on UA are few. In this paper, we will review the pharmacokinetics features of free UA and some novel UA preparations in vitro and in vivo, in order to provide a reference for rational utilization and drug design of UA.
Potent and highly selective dual‐targeting monoamine oxidase‐B inhibitors: Fluorinated chalcones of morpholine versus imidazole
Authors: Mathew Bijo , Baek Seung C. , Thomas Parambi Della G. , Lee Jae P. , Mathew Githa E. , Jayanthi Sivaraman , Vinod Devaraji , Rapheal Clariya , Devikrishna Vinod , Kondarath Shahin Shad , Uddin Md. Sahab , Kim Hoon 
Published: January 2019

AbstractTwo series of fluorinated chalcones containing morpholine and imidazole‐based compounds (f1–f8) were synthesized and evaluated for recombinant human monoamine oxidase (MAO)‐A and ‐B as well as acetylcholinesterase inhibitory activities. Our results indicate that morpholine containing chalcones are highly selective MAO‐B inhibitors having reversibility properties. All the imidazole‐based fluorinated chalcones showed weak MAO inhibitions in both isoforms. Among the tested compounds, (2E)‐3‐(3‐fluorophenyl)‐1‐[4‐(morpholin‐4‐yl)phenyl]prop‐2‐en‐1‐one (f2) showed potent inhibitory activity for recombinant human MAO‐B (IC50 = 0.087 μM) with a high selectivity index (SI) of 517.2. In the recovery experiments using dialysis, the residual activity of MAO‐B inhibited by f2 was close to that with the reversible reference inhibitor. Inhibition assays revealed that the Ki values of f1 and f2 for MAO‐B were 0.027 and 0.020 μM, respectively, with competitive patterns. All the morpholine‐based compounds (f1–f4) showed moderate inhibition toward acetylcholinesterase with IC50 values ranging between 24 and 54 μM. All morpholine‐containing compounds exhibit good blood–brain barrier permeation in the PAMPA method. The rational approach regarding the highly selective MAO‐B inhibitor f2 was further ascertained by induced fit docking and molecular dynamics simulation studies.