bluuebunny/crossref_metadata_2025_split huggingface dataset:
The collaborative care model for HIV and depression: Patient perspectives and experiences from a safety-net clinic in the United States
Authors: Fuller Shannon M , Koester Kimberly A , Erguera Xavier A , Wilde Botta Emma , von Beetzen Fredrik , Steward Wayne T , Avery Ann 
Published: April 2019

Objectives: Collaborative care models may improve outcomes for both HIV and depression. The model includes routine screening and re-assessment of depressive symptoms as well as care coordination services delivered by an ancillary provider focused on mental health. We sought to explore patient experiences and attitudes about the services received through the collaborative care model, including measurement-based care using the Patient Health Questionnaire-9. Methods: We conducted 17 qualitative interviews with patients in a collaborative care model implemented at an HIV primary care clinic in a safety-net hospital in the United States. Interviews were analyzed using Framework Analysis. Results: Our findings illustrate the ways in which the collaborative care model for depression may be meaningful to patients in HIV care settings. Participants appreciated the support offered through the collaborative care model. Most participants perceived measurement-based care as useful to their providers, and an additional subset used the Patient Health Questionnaire-9 for their own self-management and awareness of depression. Over time, the collaborative care model appeared to motivate some patients to address depressive symptoms. Conclusion: The collaborative care model may be particularly helpful to patients in the way that it reinforces how depressive symptoms can be measured and managed. Furthermore, routine screening and re-measurement for depressive symptoms using the Patient Health Questionnaire-9 hold promise as an additional self-management tool to complement other clinical and supportive services.
Explorations in Teaching Research by a Tutoring Institution in China
Authors: Bai Yunfeng , Tang Xueli , Li Xingfang , Fan Shunan 
Published: April 2019

Purpose: This article focuses on rarely explored organizational practice of teaching research in China’s private tutoring industry. Taking a large private tutoring institution as an example, the article examines how private tutoring institutions understand and engage in educational explorations of standardization and informatization processes. Design/Approach/Methods: The article is based on a case study of one of the biggest tutoring companies in China. The study started with document analysis of the institutional history, supplemented by interviews with personnel who have worked in the institution since it was founded. Next, the researchers collected empirical data using mixed methods. Quantitative data were obtained from the user database owned by the institution. Qualitative data were collected directly by the researchers through interviews and participant observation. Both qualitative and quantitative data were analyzed from multiple perspectives. Findings: Teaching research in private tutoring institutions commonly differs from that in public schooling. In this particular case, it is technology-driven, student-tailored, and process-standardized. Utilized well, it can supplement the mainstream public education system and promote education innovation and equity throughout the country. Originality/Value: It is hoped that this article could give some insights into the possibility of the cooperation between formal schools and tutoring institutions in the areas of teaching research and other in-class and off-campus activities. The article can also draw public attention to the necessity and benefits of adopting technical methods in the teaching process.
What are the effects of even-aged and uneven-aged forest management on boreal forest biodiversity in Fennoscandia and European Russia? A systematic review protocol
Authors: Savilaakso Sini , Häkkilä Matti , Johansson Anna , Uusitalo Anne , Sandgren Terhi , Mönkkönen Mikko , Puttonen Pasi 
Published: April 2019

Abstract
Background
Biodiversity is vital for human well-being, but is threatened by human actions world-wide. In the boreal zone, harvesting and management of forests on an industrial scale is the most important factor driving habitat change and degradation. Over time different forest management regimes have been implemented but their impact on biodiversity at different spatial and temporal scales has not been systematically reviewed although non-systematic reviews on the topic exist. The aim of this article is to describe a protocol for a systematic review to synthesise and compare the impacts of two different forest management systems on biodiversity at different spatial and temporal scales. The topic for the systematic review arose from the discussions with the Finnish forestry sector and was further defined in a stakeholder workshop. Research questions addressed by the systematic review protocol are: (1) What are the stand-level effects of even-aged and uneven-aged forest management on boreal forest biodiversity in Fennoscandia and European Russia? (2) What is the effect of these same forest management systems on biodiversity at landscape level?

Methods
Animal, plant, and fungal diversity is addressed. Bibliographic databases and organizational websites will be searched, and internet search engines will be utilized to find relevant literature. The searches will be conducted in English, Finnish, Swedish, and Russian. Articles will be screened regarding the inclusion and exclusion criteria at title, abstract, and full-text stage. The validity of included studies will be evaluated against appraisal criteria and studies categorized based on their risk of bias. A narrative synthesis will be conducted to describe the findings. If enough quantitative data can be retrieved from the studies, a meta-analysis will be conducted.
Irinotecan plus S‐1 versus S‐1 in patients with previously treated recurrent or metastatic esophageal cancer (ESWN 01): a prospective randomized, multicenter, open‐labeled phase 3 trial
Authors: Huang Jing , Xu Binghe , Liu Ying , Huang Junxing , Lu Ping , Ba Yi , Wu Lin , Bai Yuxian , Zhang Shu , Feng Jifeng , Cheng Ying , Li Jie , Wen Lu , Yuan Xianglin , Ma Changwu , Hu Chunhong , Fan Qingxia , Wang Xi 
Published: April 2019

AbstractBackgroundThe benefit of systemic treatments in esophageal squamous cell carcinoma (ESCC) which has progressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established. We aimed to compare the efficacy of irinotecan plus S‐1 with S‐1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum‐ or taxane‐based chemotherapy.MethodsWe conducted a prospective randomized, multicenter, open‐label, phase 3 trial in 15 centers across China. Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC, and were randomly assigned (ratio, 1:1) to receive either irinotecan plus S‐1 (intravenous infusion of irinotecan [160 mg/m2] on day 1 and oral S‐1 [80–120 mg] on days 1–10, repeated every 14 days) or oral S‐1 monotherapy (80–120 mg/day on days 1–14, repeated every 21 days) using a central computerized minimization procedure. The primary endpoint was progression‐free survival (PFS).ResultsBetween December 23, 2014 and July 25, 2016, we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S‐1 regimen (n= 61) or S‐1 monotherapy (n = 62). After a median follow‐up of 29.2 months (95% confidence interval [CI] 17.5–40.9 months), the median PFS was significantly longer in the irinotecan plus S‐1 group than in the S‐1 monotherapy group (3.8 months [95% CI 2.9–4.3 months] vs. 1.7 months [95% CI 1.4–2.7 months], hazard ratio = 0.58, 95% CI 0.38–0.86, P = 0.006). The objective response rates were 24.6% in the irinotecan plus S‐1 group and 9.7% in the S‐1 monotherapy group (P = 0.002). The patients in the irinotecan plus S‐1 group presented with increased rates of grade 3–4 leukopenia (16.4% vs. 0%), neutropenia (14.8% vs. 1.6%), and nausea (4.9% vs. 0%). No significant difference in grade 3–4 diarrhea and no treatment‐related deaths were observed in both groups.ConclusionsThe combination of irinotecan with S‐1 was similarly tolerable but significantly prolonged PFS compared to S‐1 monotherapy as a second‐ or third‐line treatment in patients with recurrent or metastatic ESCC.Clinical Trial Registration NCT02319187. Registered on December 9, 2014
Fructose Consumption Contributes to Hyperinsulinemia in Adolescents With Obesity Through a GLP-1–Mediated Mechanism
Authors: Galderisi Alfonso , Giannini Cosimo , Van Name Michelle , Caprio Sonia 
Published: April 2019

AbstractContextThe consumption of high-fructose beverages is associated with a higher risk for obesity and diabetes. Fructose can stimulate glucagon-like peptide 1 (GLP-1) secretion in lean adults, in the absence of any anorexic effect.ObjectiveWe hypothesized that the ingestion of glucose and fructose may differentially stimulate GLP-1 and insulin response in lean adolescents and adolescents with obesity.DesignWe studied 14 lean adolescents [four females; 15.9 ± 1.6 years of age; body mass index (BMI), 21.8 ± 2.2 kg/m2] and 23 adolescents with obesity (five females; 15.1 ± 1.6 years of age; BMI, 34.5 ± 4.6 kg/m2). Participants underwent a baseline oral glucose tolerance test to determine their glucose tolerance and estimate insulin sensitivity and β-cell function [oral disposition index (oDIcpep)]. Eligible subjects received, in a double-blind, crossover design, 75 g of glucose or fructose. Plasma was obtained every 10 minutes for 60 minutes for the measures of glucose, insulin, and GLP-1 (radioimmunoassay) and glucose-dependent insulinotropic polypeptide (GIP; ELISA). Incremental glucose and hormone levels were compared between lean individuals and those with obesity by a linear mixed model. The relationship between GLP-1 increment and oDIcpep was evaluated by regression analysis.ResultsFollowing the fructose challenge, plasma glucose excursions were similar in both groups, yet the adolescents with obesity exhibited a greater insulin (P &lt; 0.001) and GLP-1 (P &lt; 0.001) increase than did their lean peers. Changes in GIP were similar in both groups. After glucose ingestion, the GLP-1 response (P &lt; 0.001) was higher in the lean group. The GLP-1 increment during 60 minutes from fructose drink was correlated with a lower oDIcpep (r2 = 0.22, P = 0.009).ConclusionFructose, but not glucose, ingestion elicits a higher GLP-1 and insulin response in adolescents with obesity than in lean adolescents. Fructose consumption may contribute to the hyperinsulinemic phenotype of adolescent obesity through a GLP-1–mediated mechanism.
Inclusion and exclusion in the history of developmental biology
Authors: Hopwood Nick 
Published: April 2019

ABSTRACT
Scientific disciplines embody commitments to particular questions and approaches, scopes and audiences; they exclude as well as include. Developmental biology is no exception, and it is useful to reflect on what it has kept in and left out since the field was founded after World War II. To that end, this article sketches a history of how developmental biology has been different from the comparative, human and even experimental embryologies that preceded it, as well as the embryology that was institutionalized in reproductive biology and medicine around the same time. Early developmental biology largely excluded evolution and the environment, but promised to embrace the entire living world and the whole life course. Developmental biologists have been overcoming those exclusions for some years, but might do more to deliver on the promises while cultivating closer relations, not least, to reproductive studies.
The benefits of family planning (FP) use in Benin: an application of the Demographic Dividend Model (DemDiv)
Authors: Dansou Justin 
Published: April 2019

Background: Despite the increasing interest in improving access to and utilization of family planning (FP) methods, contraceptives prevalence rates remain low in Benin, and its benefits are not well studied. This study projected FP’s benefits for maternal health and child survival over the Sustainable Development Goals period. Methods: The Demographic Dividend Model created by the Health Policy Project using a large range of data was applied based exclusively on assumptions on FP policy options between 2015 and 2030. Results: It was found that, under the base scenario with no improvements in FP, education and economic variables, however unrealistic, the number of children per Beninese woman would be the same in 2030 as it was in 2015 – about 4.5 children per woman. Benin’s age structure would remain very young and be dominated by dependents. But, FP–scenarios of improvements in contraceptive variables alone showed a negative and linear relationship between FP use and maternal and child deaths. Under the optimistic scenario, increasing access to and use of FP alone from 7.9% (2015) to 33.95% (2030) will save lives of about 200,000 under five year children and 10,000 mothers by 2030. In addition, the average number of children per woman will fall to 3.5 increasing female life expectancy by 5 years. Benin’s age structure will be balanced with more working age people. The country will also record an increase in its human development indicator. Conclusion: To accelerate progresses towards improvement of maternal health and child survival, and get on track in meeting related health targets of SDGs, the present study revealed the importance of strengthening actions toward access to and use of FP in Benin Republic. There is also a need to strengthen education and economic policies to successfully harness the demographic dividend.
Reviews
Authors: Maclean Malcolm , McCarthy Conal , Werber Harald , Sedgwick Laura , Burke Rebecca , Valle Paola Della , Quanchi Max , Mückler Hermann , Mückler Hermann , Solsvik Reidar , McCarthy Conal , Werber Harald , Haag Oliver , Valle Paola Della 
Published: April 2019

Acknowledge No Frontier: The Creation and Demise of New Zealand’s Provinces, 1853–76, André Brett (2016) Dunedin: Otago University Press, 346 pp., ISBN 978 1 9273 2236 9 (pbk), NZ$45
The Big Smoke: New Zealand Cities, 1840–1920, Ben Schrader (2016) Wellington: Bridget Williams Books, 480 pp., ISBN 978 0 9474 9243 4 (pbk), NZ$59.99
Tears of Rangi: Experiments Across Worlds, Anne Salmond (2017) Auckland: Auckland University Press, 512 pp., ISBN 978 1 8694 0865 7 (hbk), NZ$65
The Great Wa r for New Zealand: Wa ikato 1800–2000, Vincent O’Malley (2016) Wellington: Bridget Williams Books, 690 pp., ISBN 978 1 9272 7757 7 (hbk), NZ$79.99
Passport to Hell, Robin Hyde (2015) Auckland: Auckland University Press, 344 pp., ISBN 978 1 8694 0839 8 (pbk), NZ$39.99
MATAATUA WHARENUI: TE WHARE I HOKI MAI, Hirini Moko Mead, Te Onehou Phillis, Layne Harvey and Pouroto Ngaropo (2017) Wellington: Huia, 380 pp., ISBN 978 1 7755 0212 8 (hbk), NZ$50
Tauira: Māori Methods of Learning and Teaching, Joan Metge (2015) Auckland: Auckland University Press, 320 pp., ISBN 978 1 8694 0822 0 (pbk), NZ$45
Rapa Nui – Easter Island: Cultural and Historical Perspectives, Ian Conrich and Hermann Mückler (eds) (2016) Berlin: Frank and Timme, 252 pp., ISBN 978 3 7329 0265 1 (hbk), €37.20
The Things We Value: Culture and History in Solomon Islands, Ben Burt and Lissant Bolton (eds) (2014) Canon Pyon, Herefordshire: Sean Kingston Publishing, 148 pp., ISBN 978 1 9077 7421 8 (hbk), £80
Colonialism, Maasina Rule and the Origin of Malaitan Kastom, David W. Akin (2013) Honolulu: University of Hawai‘i Press, 552 pp., ISBN 978 0 8248 3814 0 (hbk), US$59
Unearthing the Polynesian Past: Explorations and Adventures of an Island Archaeologist, Patrick Vinton Kirch (2015) Honolulu: University of Hawai‘i Press, 400 pp., ISBN 978 0 8248 5345 7 (pbk), US$45
Repositioning Pacific Arts: Artists, Objects, Histories, Anne E. Allen with Deborah B. Waite (eds) (2014) Canon Pyon, Herefordshire: Sean Kingston Publishing, 178 pp., ISBN 978 1 9077 7423 2 (hbk), £90
Sacred Histories in Secular New Zealand, Geoffrey Troughton and Stuart Lange (eds) (2016) Wellington: University of Victoria Press, 232 pp., ISBN 978 1 7765 6095 0 (pbk), NZ$40
Citizenship in Transnational Perspective: Australia, Canada and New Zealand, Jatinder Mann (ed.) (2017) Cham: Palgrave Macmillan, 322 pp., ISBN 978 3 319 53528 9 (hbk), £99.99
The New Zealand Project, Max Harris (2017) Wellington: Bridget Williams Books, 290 pp., ISBN 978 0 9474 9258 8 (pbk), NZ$39.99
ASPECTOS FARMACOLÓGICOS DO ANTICORPO MONOCLONAL (NIVOLUMAB) UTILIZANDO A VIA PD-1 NO TRATAMENTO ANTITUMORAL DO LINFOMA DE HODGKIN
Authors: Da Silva Fernanda Alves , Stroka Alessandra , Fusco Viviane 
Published: April 2019

A doença de Hodgkin, mais comumente chamada de Linfoma de Hodgkin é um tipo de câncer que acomete os gânglios do sistema linfático, nos quais se encontram células de defesa do organismo. O linfoma de Hodgkin (LH) possui as células de Reed-Sternberg (RS), portadoras de tolerância imunológica, capazes de evitar o reconhecimento do sistema imunológico, uma vez que apresentam um estado de não-reatividade específica, o que resulta em ausência de resposta a antígenos do próprio organismo. Acredita-se que a capacidade das células tumorais de evitar a ação do sistema imunológico é decorrente da super-expressão do gene 9p24, aumentando assim a codificação da proteína PD-L1, que interage com o receptor PD-1 nos linfócitos T, promovendo um sinal de imunossupressão, o que permite que a célula tumoral não seja atingida pelo linfócito T. O Nivolumab, aprovado pela FDA em 2014 e pela Anvisa em 2018, faz parte de uma classe de medicamentos direcionados à liberação de pontos de controle do sistema imunológico que regulam a resposta antitumoral. Esse fármaco atua na inibição de receptor PD-1 nos linfócitos T, bloqueando a interação deste com as proteínas PD-L1 e PD-L2. Dessa forma, esta pesquisa trata-se de uma revisão descritiva da literatura e teve por objetivo reunir informações publicadas relacionadas ao uso de imunoterapia com Nivolumab, a fim de identificar suas ações farmacológicas, bem como os efeitos adversos mais frequentes produzidos por esse fármaco. A partir desse levantamento concluiu-se que a terapia com Nivolumab é promissora, uma vez que há inúmeros relatos de casos de remissão do tumor com menos efeitos colaterais quando comparados à terapia clássica.
AVALIAÇÃO DO TEOR DE FORMALDEÍDO EM AMOSTRAS DE ALISANTES CAPILARES UTILIZADOS EM SALÕES DE BELEZA DE PEDRO GOMES, MS, BRASIL
Authors: Vitola Juliana Furtado da Silva , Da Silva Geilson Rodrigues , De Oliveira Hygor Rodrigues 
Published: April 2019

É cada vez maior a demanda pelos produtos de beleza, dentre esses, os alisantes capilares. Entre as várias substâncias que podem ser empregadas no alisamento capilar, destaca-se o formaldeído, que é utilizado com o intuito de aumentar a durabilidade e a qualidade do tratamento. Porém, que desde 2009 é permitida a utilização da concentração de 0,2% de formaldeído unicamente para a conservação do produto. Assim, a presente pesquisa teve como objetivo avaliar a concentração de formaldeído em alisantes capilares utilizados nos salões de beleza do município de Pedro Gomes, MS. Para isso, foram coletadas 28 amostras de 20 marcas distintas, em 6 salões de beleza. Para análise desses alisantes foram utilizados o método colorimétrico estipulado pelo Guia de Controle da Qualidade de Produtos Cosméticos, da Anvisa, e também o da reação da acetilacetona. Do total de amostras, 12 apresentaram concentração de formaldeído acima do permitido pela Anvisa. Com isso, os profissionais que atuam nos salões de beleza e os clientes podem estar sujeitos a complicações de saúde. Dessa forma, é importante a fiscalização das agências regulamentadoras para que esses produtos de beleza sejam retirados do comércio, visando preservar a saúde da população.
INFARMA - CIÊNCIAS FARMACÊUTICAS: 30 ANOS DIVULGANDO CONHECIMENTO NA ÁREA DAS CIÊNCIAS FARMACÊUTICAS
Authors: Oliveira Anselmo Gomes de , Silveira Dâmaris 
Published: April 2019

Com a conclusão do volume 30 (2018), o periódico Infarma - Ciências Farmacêuticas completou 30 anos de existência como um importante veículo de publicação científica oferecida pelo Conselho Federal de Farmácia. Contudo, a história de Infarma – Ciências Farmacêuticas vai além desses 30 anos.
Risk for eating disorders and body composition among adolescent female and male athletes and non-athlete controls
Authors: Pustivšek Suzana , Hadžić Vedran , Dervišević Edvin , Carruthers Jamie 
Published: April 2019

AbstractPurposeThe objective of this research was to investigate the risk for eating disorders (EDs) and compare body composition in participants with and without risk in adolescent Slovenian athletes and aged matched controls.MethodsA total of 583 randomly selected adolescents, aged from 15 to 17 years, completed a sick, control, one stone, fat, food (SCOFF) questionnaire for detecting risk for EDs. Weight and body composition were measured using a bioelectrical impedance machine. Based on the data body mass index (BMI), percentiles were calculated.ResultsOverall, 37.7% of athletes and 39.8% of controls were classified as at risk for EDs. Girls showed a significantly higher frequency of risk than boys, 1:3.5. A higher percentage of underweight boys was found in control group compared to the athletes, but the difference was not significant in the subsample of girls. Differences in body composition show that the at-risk group had significantly higher values in BMI percentiles (p < 0.001) and percentages of fat mass (p < 0.001) and lower values in percentage of muscle mass (p < 0.01) and fat-free mass.ConclusionsThese finding demonstrate that the gap in risk for EDs between males and females is becoming smaller and stresses to consider specific parameters of body composition as being important when identifying at-risk groups for EDs.
Crystal structure of catena-poly[diaqua-bis(μ2-4-((4-(pyridin-2-ylmethoxy)phenyl)diazenyl)benzoato-κ3
O,O′:N)cadmium(III)], Cd(C19H14O3N3)2(H2O)
Authors: Zhao Ying 
Published: April 2019

Abstract
C38H30N6O7Cd, monoclinic, C2/c (no. 15), a = 16.937(3) Å, b = 6.1323(12) Å, c = 33.322(7) Å, β = 99.31(3)°, V = 3415.4(12) Å3, Z = 4, R
gt(F) = 0.0314, wR
ref(F
2) = 0.0668, T = 296(2) K.
Knowledge Status and Disease Control Practices of Cassava Farmers in Delta State, Nigeria: Implications for Extension Delivery
Authors: Ebewore Solomon Okeoghene , Isiorhovoja Rodney Akpoviri 
Published: April 2019

Abstract
The study assessed the knowledge and control of cassava diseases by farmers in Delta State, Nigeria and the resultant implication for agricultural extension. Data were obtained from 569 cassava farmers by a simple random sampling technique. Data were analyzed by means, percentage, frequency counts and binary logit model. Mean results depicted that cassava farmers in the area were 42.5 years old, spent 13 years in schooling, had a farming experience of 9.5 years and had poor (1.68) annual extension contacts. Extension contact and friends and neighbours were the major sources of information on cassava disease control. Results of the logit regression of the relationship between farmers’ characteristics and knowledge of cassava diseases gave an R2 value of 0.74 indicating that age (negative coefficient), education, farming experience, farm size and extension contact were statistically significant in explaining cassava farmers knowledge of disease control measures. Logit estimates for control of diseases indicated that age, farming experience, farm size and extension contact were statistically significant at P<0.05. Although education was crucial in determining farmers’ knowledge, it was not significant in determining adoption of control measures. The study recommends urgent and good extension contact, good government policy on enlightenment of farmers to improve not only farmers’ knowledge but their adoption of disease control measure as well.