bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase 3, randomized, double-blind trial of pembrolizumab in the adjuvant treatment of renal cell carcinoma (RCC): KEYNOTE-564.
Authors: Quinn David I. , Zhang Tian , Gurney Howard , Doshi Gurjyot K. , Cobb Patrick Wayne , Parnis Francis , Lee Jae-Lyun , Park Se Hoon , Semenov Andrey , Chang Wayne Yen-Hwa , Powles Thomas , Wan Shuyan (Sabrina) , Poehlein Christian Heinrich , Choueiri Toni K. 
Published: February 2018

TPS712 Background: Most patients with intermediate- to high-risk advanced renal cell carcinoma (RCC) will progress within 3 years following nephrectomy. Novel treatments in the adjuvant setting are needed to prevent disease recurrence in these higher-risk patients. Upregulation of the programmed death 1 (PD-1) pathway is associated with more aggressive disease and poor prognosis. PD-1 inhibitors have demonstrated activity in metastatic RCC, and PD-1 may represent a novel therapeutic target in the adjuvant setting. Pembrolizumab, a PD-1 inhibitor, blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. Methods: KEYNOTE-564 (NCT03142334) is a randomized, double-blind, placebo-controlled phase 3 trial designed to evaluate the efficacy and safety of pembrolizumab as adjuvant therapy in patients with RCC. Eligibility criteria include age ≥18 years; intermediate- to high-risk (T2 grade 4, T3), high-risk (T4, T), or M1 NED RCC with a clear cell component; no prior systemic therapy for advanced RCC; disease free following complete or partial nephrectomy (and metastasectomy in patients with M1 NED) with negative surgical margins; Eastern Cooperative Oncology Group performance status (ECOG PS) 0/1; and provision of a tumor sample for biomarker analyses. Patients will be randomly assigned (1:1) to pembrolizumab 200 mg administered intravenously every 3 weeks or placebo. Randomization will be stratified by metastasis stage (M0 vs M1 NED); within the M0 group, randomization will be further stratified by ECOG PS (0 vs 1) and region (US vs rest of world). Treatment will continue until disease recurrence, unacceptable toxicity, or the completion of 17 cycles (~1 year). Imaging will be performed every 12 weeks. The primary end point is disease-free survival (DFS) per investigator assessment. The key secondary end point is overall survival (OS). Other secondary objectives include safety, disease recurrence-specific survival, DFS and OS according to PD-L1 expression status, and patient-reported outcomes. Biomarkers that may be associated with response will be evaluated as an exploratory objective. Enrollment is ongoing and will continue until ~950 patients are enrolled. Clinical trial information: NCT03142334.
MDSC clinical assay for cancer detection and monitoring in renal cell carcinoma.
Authors: Basu Arnab , Kollengode Kanthi Athreya , Danenberg Genevieve , Manoli Hugh , Rafatnia Ali , Chakravartty Eesha , Epstein Alan L. , Pinski Jacek K. 
Published: February 2018

TPS713 Background: Human Myeloid Derived Suppressor Cells (MDSCs) have gained recognition as a significant population of cells that arise in cancer patients to mediate immune tolerance. Some studies have shown MDSC concentrations to be associated with overall survival and response to therapy in renal cell carcinoma. MDSCs comprise a heterogenous population that are yet to be fully characterized. We have identified a set of biomarkers uniquely expressed by the suppressive human MDSC phenotype and have developed an assay targeted to these markers. MDSCs are potentially a relatively cheap and easily performed screening and monitoring tool in cancers. This study will examine how a proprietary clinical assay works in detecting and monitoring MDSCs in blood and urine samples from patients with localized or metastatic renal cell cancer. Methods: The pilot research trial will enroll 63 subjects in a 1:1:1 ratio in three groups, normal controls over age 40 without evidence of any malignancy, patients with metastatic disease and localized renal cell carcinoma prior to nephrectomy. This sample size provides 80% power to detect a 1SD difference in MDSC concentrations in these groups on an F test. Blood and urine samples will be drawn at baseline and at 4 months for comparison. The percent CD33+ HLA-DRlow HIF1a+, CD33+ HLADRlow C/EBPb+, CD11b+ HLA-DRlow HIF1a+, and CD11b+ HLA-DRlow C/EBPb+cells as a fraction of PBMC will be determined. Primary Outcome Measures will be 1. Change in MDSC levels in patients with known localized renal cell carcinoma who undergo surgical treatment. 2. Change in MDSC level in patients with known metastatic renal cell carcinoma who initiate systemic treatment and 3. The direction and magnitude of the changes compared with radiographically assessed tumor burden. Secondary outcome measures are to assess MDSC level measurements in urine cytology analysis at baseline and after treatment to determine whether the two tests correlate in any of the 3 groups of patients defined in this study. Conclusion: This pilot study will examine if a MDSC clinical assay works in detecting and monitoring MDSCs. Recruitment is open to patients at the USC Cancer center and LAC+USC medical center. Clinical trial information: NCT02664883.
Ιταλικός κινηματογραφικός νεορεαλισμός και ελληνική μεταπολεμική πεζογραφία: Νεορεαλιστική γραφή στο Άνθρωποι και σπίτια του Αντρέα Φραγκιά.
Authors: Φραγκούλη Νάντια Αυγερινός 
Published: February 2018

The years 1951-1961 mark the reception of Italian neorealist cinema in Greece with the production of films influenced by neorealism and the discussion of the nature of neorealism by Greek film critics. The novel Anthropi ke spitia [Of Houses and Men] by Adreas Fragkias, published in 1955, four years after the first viewing of De Sica’s Bicycle Thief in Greece, shows significant similarities to the themes and style of the Italian neorealist cinema. Discussing unemployment as a crucial problem of post-war Greek society Anthropi ke spitia presents the life in a poor urban neighbourhood in a series of seemingly random episodes that B. Klaras in his review of the book called ‘cinematic tableaux’. Most importantly, however, it seems that Fragkias’ novel explores the boundaries and the style of realism in post-war literature in a way that resonates the aesthetic principles of the Italian neorealistic films.
Physical Activity Research in Intellectual Disability: A Scoping Review Using the Behavioral Epidemiological Framework
Authors: Pitchford E. Andrew , Dixon-Ibarra Alicia , Hauck Janet L. 
Published: February 2018

Abstract
Through a scoping review, the current state of physical activity research in people with intellectual disability was examined. A search of publications between 2000 and 2014 retrieved 362 articles that met inclusion criteria. Eligible studies were coded according to the Behavioral Epidemiological Framework. Of the articles identified, 48% examined associations between physical activity and health outcomes, 9% developed or tested methodology to measure physical activity, 34% examined factors that influence physical activity, 8% evaluated interventions to change physical activity, and 1% examined the dissemination of physical activity/health promotion programming. The categories with lower proportions of studies represent the need for greater population-specific research in physical activity measurement, interventional designs, and translational programs.
Liquid Profiling of Circulating Tumor DNA in Plasma of Melanoma Patients for Companion Diagnostics and Monitoring of BRAF Inhibitor Therapy
Authors: Haselmann Verena , Gebhardt Christoffer , Brechtel Ingrid , Duda Angelika , Czerwinski Claudia , Sucker Antje , Holland-Letz Tim , Utikal Jochen , Schadendorf Dirk , Neumaier Michael 
Published: February 2018

Abstract

BACKGROUND
The current standard for determining eligibility of patients with metastatic melanoma for BRAF-targeted therapy is tissue-based testing of BRAF mutations. As patients are rarely rebiopsied, detection in blood might be advantageous by enabling a comprehensive assessment of tumor mutational status in real time and thereby representing a noninvasive biomarker for monitoring BRAF therapy.

METHODS
In all, 634 stage I to IV melanoma patients were enrolled at 2 centers, and 1406 plasma samples were prospectively collected. Patients were assigned to 3 separate study cohorts: study 1 for assessment of circulating tumor DNA (ctDNA) as part of companion diagnostics, study 2 for assessment of ctDNA for patients with low tumor burden and for follow-up, and study 3 for monitoring of resistance to BRAF inhibitor (BRAFi) or mitogen-activated protein kinase inhibitor therapy.

RESULTS
Overall, a high degree of concordance between plasma and tissue testing results was observed at 90.9% (study 1) and 90.1% (study 2), respectively. Interestingly, discrepant results were in some cases associated with nonresponse to BRAFi (n = 3) or a secondary BRAF-mutant malignancy (n = 5). Importantly, ctDNA results correlated with the clinical course of disease in 95.7% and with response to treatment. Significantly, the detection of BRAF mutant ctDNA preceded relapse assessed by Response Evaluation Criteria in Solid Tumors, and was more specific than serum S100 and lactate dehydrogenase.

CONCLUSIONS
Blood-based testing compares favorably with standard-of-care tissue-based BRAF mutation testing. Importantly, blood-based BRAF testing correlates with the clinical course, even for early-stage patients, and may be used to predict response to treatment, recurrence, and resistance before radioimaging under BRAFi therapy, thereby enabling considerable improvements in patient treatment.
Disparities in incidence and mortality of pancreatic cancer in the world
Authors: Khani Yousef , Arabsalmani Masoumeh , Pakzad Reza , Ghoncheh Mahshid , Mohammadian-Hafshejani Abdollah , Salehiniya Hamid 
Published: February 2018

Background: Pancreatic cancer (PC) is as the twelfth most frequent cancer and the seventh most important cause of mortality by reason of cancer in the world. Being informed about the incidence and mortality of this cancer and the potential role of development is useful in health policy. The aim of this research is investigating disparities in the incidence and mortality of PC in the world countries in the year 2012.
Methods: This study was an ecologic study in the World for assessing the correlation between Human Development Index (HDI) and its details (Gross national income (GNI) per capita, average years of schooling and life expectancy at birth) with age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) of PC.
Results: In total, 337872 new cases of PC occurred in 2012 around the world , that 178116 and 159711 cases take happen in men and women respectively, also at the same year 330391 deaths of PC occurred ,that 173,827 and 156564 cases were in men and women. In assessment the relationship between HDI and ASIR and ASMR of PC there is significant positive correlation equal to 0.767 (p <0.001) between HDI and ASIR of PC, and a significant positive correlation equal to 0.776 (p <0.001) between HDI and ASMR of PC.
Conclusion: The incidence and mortality of PC has a significant positive correlation with the Human Development Index.
Cross-Linguistic Influence in L3 Spanish and Relationship between Language Proficiency and Type of Lexical Errors/Međujezični Utjecaji između Španjolskog J3, Engleskog J2 i Hrvatskog J1 te Veze između Jezičnog Umijeća i Vrste Leksičkih Pogrešaka
Authors: Peric Barbara , Novak Mijic Sonja 
Published: February 2018

Abstract This study is focused on lexical cross-linguistic influences in Spanish third language (L3) acquisition. Participants are learners with Croatian first language (L1) and English second language (L2). The study investigates the relationship between L3 proficiency and types of lexical errors. Our hypotheses are focused on two main points: type of language transfer can be related to formal similarity of certain features or language components and to L2 proficiency as well and therefore English L2 will be the main source in both - transfer of form and transfer of meaning and the type of lexical errors is changed with the higher level of proficiency. Calques are more frequent, and code-switching is reduced (Celaya, 2006, 2008). There were 50 participants in this research and all of them are second and third year students of the American College of Management and Technology. Our hypotheses were confirmed on the basis of the error analysis in the compositions of the second and third year students. Key words: Calques; formal similarity; transfer of form; transfer of meaning Međujezični utjecaji između španjolskog J3, engleskog J2 i hrvatskog J1 te veze između jezičnog umijeća i vrste leksičkih pogrešaka Sažetak U središtu pozornosti ovog istraživanja su leksički međujezični utjecaji prilikom usvajanja španjolskog jezika kao trećeg stranog jezika kod učenika kojima je hrvatski jezik prvi/ materinski jezik, a engleski drugi jezik. U ovom radu smo također proučavali veze između jezičnog umijeća u trećem jeziku i vrste leksičkih pogrešaka. Cilj našeg istraživanja je istražiti hrvatske i engleske međujezične utjecaje, a naše pretpostavke su usmjerene na dvije glavne točke: vrsta promatranog jezičnog prijenosa može biti povezana s formalnom sličnosti između određenih značajki ili komponenti jezika te će tako engleski jezik kao J2 biti preferirani izvor leksičkoga prijenosa te da se proizvodnja kalkova povećava kako učenici postaju kompetentniji u trećem jeziku. Istraživanje je provedeno na uzorku od 50 ispitanika. Svi ispitanici su studenti druge i treće godine na Američkoj visokoj školi za menadžment i tehnologiju. Metodom analize pogrešaka analizirani su završni pismeni radovi te potvrđene naše pretpostavke. Ključne riječi: formalna sličnost; kalkovi; prijenos forme; prijenos značenja
En tiempos de atribulación social y moral
Authors: Escobar Mesa Augusto 
Published: February 2018

En una pieza de teatro de Henrik Ibsen titulada Un enemigo del pueblo, escrita en 1882, el dramaturgo noruego pone en escena una historia cotidiana pero sugerente en la que revela lo que hasta entonces había pasado siempre. Y, podemos decir, continúa pasando, mucho más ahora en tiempos de la globalización en los que una pequeña comunidad de poderosos de las grandes urbes actúa de igual manera...
Satura. Ensayos
Authors: Herrera Camilo 
Published: February 2018

Llama la atención que Satura, una recopilación de ensayos de Jaime Alberto Vélez publicados previamente en El Malpensante entre 1998 y 2003, y reeditados en la Colección Bicentenario de Antioquia, parezca dar crédito a lo que el ensayista antioqueño define como el comportamiento propio de la viuda del escritor...
A SURVEY ON YOUNG PEOPLE’S PURPOSES AND COMMUNICATIONS ACTIVITIES IN COFFEE SHOPS IN BANDA ACEH
Authors: Syam Hamdani M 
Published: February 2018

The purpose of this study was to investigate the young people communication activities and purposes in coffee shops in Banda Aceh. The objectives of this study were to investigate why young people either male or female (in Banda Aceh) hang out at coffee shops and what they are doing there.
The method employs in this study are quantitative in nature. The survey is used to collect the data needed for this study. A set of the questionnaire is distributed to 1,500 young people who were hanging out in coffee shops in Banda Aceh. The data collected were analyzed through SPSS in the form of percentages.
The results showed that the main reasons for hanging out in the coffee shops, apart from drinking coffee, were to chat with friends, look for entertainment and fill in time. The main form of communication was small talk and amusement. At the same time, those who talked about their studies did not get satisfaction. These young people also usually used the internet while they were in the coffee shops – to play games, chat with (other) friends and also to get materials for study.
Limitations of this study were that only questionnaire was used to get the data. As a matter of fact, the interview should be done to get the detail data. However, this study has given valuable information for readers in general in relation to the activities and purposes of hanging out at the coffee shops among young people in Aceh.
This study has never been done before especially in Aceh. This study also provided current information on what communication activities and purposes of young people in coffee shops in Aceh.
A TEMÁTICA AMBIENTAL NO ENSINO SUPERIOR: UM ESTUDO SOBRE A UNIVERSIDADE FEDERAL DE RONDÔNIA, CÂMPUS DE PORTO VELHO
Authors: Barba Clarides Henrich de , Feiteiro Cavalari Rosa Maria 
Published: February 2018

<p>Este artigo analisa a inserção da temática ambiental na Universidade Federal de Rondônia (Unir),<em> campus</em> de Porto Velho. Caracteriza-se como estudo de caso, tendo como instrumentos de coleta de dados: a análise documental dos projetos pedagógicos e dos planos das disciplinas de 14 cursos de graduação que desenvolvem a temática ambiental, entrevistas semidiretivas com os coordenadores e professores. A “análise de conteúdo” proposta por Bardin e as características de <em>Ambientalização</em> curricular elaboradas pela Rede Aces foram utilizadas na análise dos dados. Os resultados demonstram que os cursos estão <em>ambientalizados</em> ou em processo de <em>Ambientalização </em>curricular, sobretudo<em> </em>os de Geografia e Ciências Biológicas. Identificaram-se seis características de um currículo <em>ambientalizado</em>: compromisso com a transformação das relações sociedade-natureza, complexidade, contextualização local-global-local global-local-global, levar em conta o sujeito na construção do conhecimento; considerar os aspectos cognitivos e afetivos, éticos e estéticos, espaços de reflexão e participação democrática, orientação prospectiva de cenários alternativos.</p><p><strong> </strong></p><p><strong>Palavras-chave</strong>: <em>Ambientalização</em> Curricular. Temática ambiental. Educação Ambiental.<em></em></p>
Efektifitas Latihan Fisik Yoga terhadap Kadar Gula Darah Sewaktu pada Diabetes Mellitus Tipe 2 di Kramat Jakarta
Authors: Suwarno Maria Lousiana , Sianturi Sondang Ratnauli 
Published: February 2018

<p><em>Diabetes mellitus type 2 is the most common type of diabetes is found around the world. It is estimated in the year 2035 will occur explosion sufferers of diabetes mellitus. Diabetes Mellitus not controlled then it may cause complications in organs – other organs such as: heart, kidneys and eyes. There are several treatment Diabetes Mellitus, one of which is the physical exercises of </em>yoga<em>.In this study, aiming to let acquired clarity about the effectiveness of physical yoga exercises against the respondent's blood sugar. This research is quasi alphabets experiment with the design of the intervention group pre test – post test. The Sampling method by using the Krejcie table population size (N) 55 and the number of samples (S) 48. Data analysis with Ordinal Regression and difference test. On this group intervention is done as much as once a week for 3 months.The statistical test used different test pretest and post test. Ordinal regression test results showing that yoga changes have an effect on blood sugar levels while (Pvalue 0.003). On different wilxoson test results obtained p = 0.006, meaning that there is a difference in blood sugar during before and after physical exercises of yoga. Conclusion this study is physical exercise yoga </em>effective<em> for lowering blood sugar levels while in type 2 DM, then it is recommended that the Ministry of Health introduced this intervention, in the independent care of patients at home, so that patients can control their blood sugar levels</em></p>
Faktor-Faktor yang Mempengaruhi Burnout pada Wanita Bekerja di Kabupaten Banyumas
Authors: Swasti Keksi Girindra , Ekowati Wahyu , Rahmawati Eni 
Published: February 2018

<p><strong>ABSTRACT</strong></p><p>The globalization era has given many changes in some aspects of life such as women participation in work field. There are women can perform their potential ability in doing their work. The effects of doing their role, women oftentimes feel weary not only physical but also mental and emotional therefore it can influence their work performance and personal life. This condition is called by “burnout”. Burnout is influenced by individual, environment and cultural factor. Based on that problem, the researcher is interested to find out some factors that influence burnout for working women in Banyumas Regency. This research is quantitative by descriptive analysis design and the sample is chosen by simple random sampling. The relationship between characteristic of respondent demography and burn out was analyzed by Chi-Square and Sommers d test. The result of analysis are 55% respond are mild burnout and 42,5% are moderate burnout. Level of education, kind of work, amount of income and work duration are some factors that influence burnout for working women in Banyumas Regency. Based on that fact, it is needed some efforts to prevent sustainable burnout. </p><p><strong>ABSTRAK</strong><strong></strong></p><p>Era globalisasi telah memberikan banyak perubahan dalam berbagai aspek kehidupan, termasuk partisipasi wanita dalam lapangan pekerjaan. Tidak sedikit wanita yang mampu menunjukkan potensinya dalam menjalankan peran diberbagai bidang keahliannya. Dalam menjalankan perannya, seringkali wanita merasakan kelelahan yang berlebihan, tidak hanya fisik namun juga mental dan emosional yang kemudian berimbas pada performa kerja dan kehidupan personalnya. Kondisi ini dikenal dengan istilah <em>burnout. Burnout</em> dipengaruhi oleh faktor individu, lingkungan, dan budaya. Berdasarkan hal tersebut peneliti tertarik untuk mengetahui faktor-faktor yang mempengaruhi <em>burnout</em> pada wanita bekerja di Kabupaten Banyumas. Penelitian ini merupakan penelitian kuantitatif dengan desain analisis deskriptif. Sampel dipilih secara <em>simple ramdom sampling</em>. Analisis hubungan karakteristik demografi responden dengan <em>burnout</em> dilakukan dengan Uji <em>Chi Square dan Sommers d</em>. Hasil analisis diketahui bahwa 55% responden mengalami <em>burnout</em> ringan dan 42,5% lainnya mengalami <em>burnout</em> sedang. <em>Burnout</em> pada wanita bekerja di Kabupaten Banyumas dipengaruhi oleh faktor tingkat pendidikan, jenis pekerjaan, penghasilan, dan jam bekerja. Oleh karena itu, diperlukan upaya penanganan untuk mencegah <em>burnout</em> yang berkelanjutan.</p>