bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetics of hepatocellular carcinoma
Authors: Toh Tan Boon , Lim Jhin Jieh , Chow Edward Kai‐Hua 
Published: May 2019

AbstractIn recent years, large scale genomics and genome‐wide studies using comprehensive genomic tools have reshaped our understanding of cancer evolution and heterogeneity. Hepatocellular carcinoma, being one of the most deadly cancers in the world has been well established as a disease of the genome that harbours a multitude of genetic and epigenetic aberrations during the process of liver carcinogenesis. As such, in depth understanding of the cancer epigenetics in cancer specimens and biopsy can be useful in clinical settings for molecular subclassification, prognosis, and prediction of therapeutic responses. In this review, we present a concise discussion on recent progress in the field of liver cancer epigenetics and some of the current works that contribute to the progress of liver cancer therapeutics.
The Midwife and the Poet
Authors: Reinert Hugo 
Published: May 2019

Abstract
Triangulating narratives from a prospective mining site in northern Norway, this article works to identify (and render graspable) a particular effect of retroactive shock—tracing its resonance through experiences of chemical exposure, colonial racism, cultural erasure, and destruction of the built environment. Linking these experiences, the argument sets up and explores an analytical space within which the toxic modernity of planetary capitalism can resonate, structurally, with the racist violence of state colonialism: a space that also, the author suggests, describes an important dimension of Anthropocene experience itself.
The Impact of Morning versus Afternoon Exercise on Iron Absorption in Athletes
Authors: MCCORMICK RACHEL , MORETTI DIEGO , MCKAY ALANNAH K. A. , LAARAKKERS COBY M. , VANSWELM RACHEL , TRINDER DEBBIE , COX GREGORY R. , ZIMMERMAN MICHAEL B. , SIM MARC , GOODMAN CARMEL , DAWSON BRIAN , PEELING PETER 
Published: May 2019

ABSTRACT

Purpose
This study examined postexercise inflammatory, hepcidin, and iron absorption responses to endurance exercise performed in the morning versus the afternoon.

Methods
Sixteen endurance-trained runners (10 male, 6 female) with serum ferritin (sFer) < 50 μg·L−1 completed a 90-min running protocol (65% vV˙O2max) in the morning (am), or the afternoon (pm), in a crossover design. An iron-fortified fluid labeled with stable iron isotopes (57Fe or 58Fe) was administered with a standardized meal 30 min following the exercise and control conditions during each trial, serving as a breakfast and dinner meal. Venous blood samples were collected before, immediately after, and 3 h after the exercise and control conditions to measure sFer, serum interleukin-6 (IL-6), and serum hepcidin-25. A final venous blood sample was collected 14 d after each trial to determine the erythrocyte iron incorporation, which was used to calculate iron absorption. Linear mixed-modeling was used to analyze the data.

Results
Overall, exercise significantly increased the concentrations of IL-6 (4.938 pg·mL−1; P = 0.006), and hepcidin-25 concentrations significantly increased 3 h after exercise by 0.380 nM (P < 0.001). During the pm trial, hepcidin concentrations exhibited diurnal tendency, increasing 0.55 nM at rest (P = 0.007), before further increasing 0.68 nM (P < 0.001) from prerun to 3 h postrun. Fractional iron absorption was significantly greater at breakfast after the am run, compared with both the rested condition (0.778%; P = 0.020) and dinner in the am run trial (0.672%; P = 0.011).

Conclusions
Although exercise resulted in increased concentrations of IL-6 and hepcidin, iron was best absorbed in the morning after exercise, indicating there may be a transient mechanism during the acute postexercise window to promote iron absorption opposing the homeostatic regulation by serum hepcidin elevations.
Change in Physical Activity and Cardiac Structure over 10 Years: The Multi-Ethnic Study of Atherosclerosis
Authors: FLORIDO ROBERTA , ZHAO DI , NDUMELE CHIADI E. , BLUEMKE DAVID A. , HECKBERT SUSAN R. , ALLISON MATTHEW A. , AMBALE-VENKATESH BHARATH , LIU CHIA-YING , LIMA JOAO , MICHOS ERIN D. 
Published: May 2019

ABSTRACT

Introduction
Physical activity (PA) is inversely associated with risk of heart failure and cardiovascular disease (CVD), whereas increased left ventricular (LV) mass and mass to volume (m:v) ratio are unfavorable CVD risk factors. We assessed whether changes in leisure time PA were associated with longitudinal changes in cardiac structure in a community-based population.

Methods
We included 2779 Multi-Ethnic Study of Atherosclerosis participants, free of baseline CVD, who had available data on PA and cardiac magnetic resonance imaging at examinations 1 (2000–2002) and 5 (2010–2012). Physical activity was measured by a Typical Week PA Survey and converted to MET-minutes per week of moderate+vigorous activity. We used linear mixed effect models to estimate the associations of baseline and change in PA with baseline and change in cardiac structure, adjusting for CVD risk factors and body size.

Results
At baseline, the mean age was 59 yr, 53% were women, and 58% of nonwhite race/ethnicity. During average 10-yr follow-up, and after accounting for baseline PA levels, the highest quintiles of PA increase were significantly associated with increases in LV mass (2.3 g; 95% confidence interval [CI], 0.4–4.2), LV end-diastolic volume (4.7 mL; 95% CI, 2.4–7.0), and stroke volume (3.3 mL; 95% CI, 1.6–5.1), but lower M:V ratio (−2.9; 95% CI, −5.0 to −0.8) compared with the lowest quintiles. Increasing exercise PA was associated with increases in LV diameter and reductions in M:V ratio, whereas occupational PA was associated with increases in m:v ratio. Increasing PA over 10 yr was also associated with greater risk of eccentric dilated LV hypertrophy at examination 5.

Conclusions
After accounting for baseline PA, greater positive changes in leisure-time PA levels were associated with a more eccentric-type of LV remodeling pattern over 10 yr. The clinical implications of such findings remain to be determined.
One-Year Lifestyle Intervention, Muscle Lipids, and Cardiometabolic Risk
Authors: MALTAIS ALEXANDRE , LEMIEUX ISABELLE , ALMÉRAS NATALIE , TREMBLAY ANGELO , BERGERON JEAN , POIRIER PAUL , DESPRÉS JEAN-PIERRE 
Published: May 2019

ABSTRACT

Purpose
Low-attenuation muscle (LAM) area at mid-thigh, a computed tomography (CT)–derived index of intramuscular lipids, is associated with insulin resistance, obesity, and type 2 diabetes. The present study aimed at testing the hypothesis that changes in LAM area in trunk muscles from a single abdominal scan could provide relevant information to evaluate the effects of a lifestyle intervention without the use of a mid-thigh CT scan.

Methods
Cardiometabolic risk variables, including waist circumference, lipoprotein–lipid profile, glucose tolerance, and cardiorespiratory fitness, were assessed in a sample of 102 dyslipidemic viscerally obese men at baseline and after a 1-yr lifestyle intervention. Abdominal (L4–L5) and mid-thigh CT scans were performed and abdominal muscles classified as psoas and core muscles. Scans were segmented to calculate muscle areas, LAM areas, and mean attenuation values.

Results
All muscle groups showed a decrease in LAM areas (P < 0.0001) in response to the lifestyle intervention. Changes in LAM areas were significantly associated with changes in triglycerides, high-density lipoprotein (HDL) cholesterol, cholesterol/HDL cholesterol ratio and log triglycerides/HDL cholesterol ratio (mid-thigh, 0.20 ≤ |r| ≤ 0.29; psoas, 0.28 ≤ |r| ≤ 0.38; core, 0.29 ≤ |r| ≤ 0.34, P < 0.05). Changes in core LAM area were significantly associated with changes in 2-h glucose levels, glucose area measured during the oral glucose tolerance test and homeostasis model assessment of insulin resistance (0.21 ≤ r ≤ 0.34, P < 0.05). Stepwise regression analyses showed that changes in LAM psoas area were associated with changes in HDL cholesterol and the cholesterol/HDL cholesterol ratio independently from changes in visceral adiposity.

Conclusions
Changes in trunk LAM areas are useful indices of changes in mid-thigh LAM area observed with a 1-yr lifestyle intervention. Thus, an additional mid-thigh scan is not necessary to evaluate muscle lipid content by CT when an abdominal CT scan is available.
Bernard Soulier Syndrome: 10 years’ experience at a tertiary care hospital
Authors: Farhan Saima , Iqbal Irem , Ahmed Nisar 
Published: May 2019

Objective: To determine clinical manifestations and laboratory findings in patients with BSS diagnosed through platelet aggregometry followed in a tertiary care hospital in Lahore, Pakistan.
Methods: The retrospective study comprised patients who presented in Hematology and Transfusion Medicine Department of The Children Hospital & Institute of Child Health, Lahore with the relevant diagnosis from 2006 to 2013. The result of all the patients were collected on a predesigned proforma. Medical data was scrutinized to collect age, gender, clinical findings along with results of complete blood count, bleeding time and platelet aggregation studies for the diagnosis of Bernard Soulier Syndrome.
Results: Among 49 patients, 26 patients were females and 23 males. The mean age of the patients was 5±2.5 years. 81% had a family history of consanguinity. The most common presenting symptom included epistaxis seen in 73.4% patients. Complete blood count demonstrated decreased platelets in 85.7% of patients ranging from 20 X 109/L to 130 X 109/L. Anemia was seen in 67.3% and 93.8% had prolonged bleeding time. Peripheral blood smears demonstrated giant platelets in all patients. The majority of patients 65.3% had mild bleeding episodes. Platelet aggregation studies showed normal aggregation with ADP, Collagen and Epinephrine in 100% of our patients whereas all showed no response of aggregation with Ristocetin.
Conclusion: Our data is consistent with other reports regarding clinical presentation of BSS, but we report large number of BSS patients from our area, emphasizing significance to provide diagnostic services in Pakistan to find out exact magnitude of disease.
doi: https://doi.org/10.12669/pjms.35.3.980
How to cite this:Farhan S, Iqbal I, Ahmed N. Bernard Soulier Syndrome: 10 years’ experience at a tertiary care hospital. Pak J Med Sci. 2019;35(3):705-708. doi: https://doi.org/10.12669/pjms.35.3.980
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Perioperative comprehensive geriatric assessment: what do we need to know?
Authors: Trundle Simon , Gooneratne Mevan , Rogerson Andrew , Dhesi Jugdeep 
Published: May 2019

As a consequence of an ageing population greater numbers of elderly patients are presenting for both elective and emergency surgery. These older patients typically present with an increased burden of age-related problems and multimorbidity, which is associated with an increased risk of adverse postoperative outcomes. Traditional preoperative assessment models are adept at discerning patients' suitability for anaesthesia and surgery, but there is minimal focus on improving postoperative outcomes.Comprehensive geriatric assessment is a multidisciplinary approach used both to assess existing ‘known’ pathology and to screen for previously undiagnosed issues across medical, functional, social and/or psychological domains. This diagnostic phase then leads to the development and implementation of an individualized ‘optimization’ strategy across these domains. There is emerging evidence that comprehensive geriatric assessment and optimization in the surgical setting leads to improved outcomes, and it is reasonable to conclude that it would benefit the patient's long-term health.
The Struggle for Rights at Work
Authors: Taylor Jeffery 
Published: May 2019

For decades Canadian trade unionists have expressed frustration with the grievance arbitration system, but this tends to be limited to criticisms of the legalistic nature of the process and the costs and delays involved in getting a judgement. There is little discussion or debate about the denial of the right to strike, which is the central feature of the system. Nor is there much discussion about approaches to contract enforcement that situate legal strategies in broader political strategies to use worker power effectively, including the withdrawal of labour. This study investigates how the United Electrical Workers (ue), a left-led union, defended workers’ rights at Canadian General Electric (cge) and Westinghouse in the early years of the new legal regime. Specifically, it charts the North American origins of grievance arbitration systems, sketches the development of personnel policies in the electrical industry, surveys the ue Canadian district’s struggle to establish contractual relations and codify workplace rights at these two corporations, reconstructs the elements of ue’s approach to contract enforcement, and reviews a number of mid-contract work stoppages at cge and Westinghouse between 1946 and 1966 to determine how the union, workers, employers, and arbitrators negotiated the ban on grievance strikes as they adjusted to new legislation and new collective agreement language.

Pendant des décennies, les syndicalistes canadiens ont exprimé leur frustration à l’égard du système d’arbitrage des griefs, mais cela tend à se limiter aux critiques sur la nature légaliste du processus, ainsi que sur les coûts et les retards liés à l’obtention d’un jugement. Il y a peu de discussions ou de débats sur la dénégation du droit de grève, qui est la caractéristique centrale du système. Il n’y a pas non plus beaucoup de discussions sur les méthodes d’application des contrats qui situent les stratégies juridiques dans des stratégies politiques plus larges pour utiliser efficacement le pouvoir des travailleurs, y compris le retrait du travail. Cette étude examine comment le United Electrical Workers (ue), un syndicat dirigé par la gauche, a défendu les droits des travailleurs chez Canadian General Electric (cge) et Westinghouse dans les premières années du nouveau régime juridique. Plus précisément, elle retrace les origines nord-américaines des systèmes d’arbitrage des griefs, esquisse le développement des politiques du personnel dans l’industrie électrique, passe en revue les difficultés rencontrées par le district canadien de l’ue pour établir des relations contractuelles et codifier les droits du travail dans ces deux entreprises, reconstruit les éléments de l’approche de l’ue à l’exécution des contrats et examine un certain nombre d’arrêts de travail à mi-contrat chez cge et Westinghouse entre 1946 et 1966 pour déterminer comment le syndicat, les travailleurs, les employeurs et les arbitres ont négocié l’interdiction des grèves de grief à mesure qu’elles s’adaptaient à la nouvelle législation et au nouveau libellé de la convention collective.
Le travail gestionnaire comme psychopolitique au service de la transformation sociale du Québec
Authors: Pezet Anne 
Published: May 2019

Cet article porte sur un type de travail trop peu étudié : le travail gestionnaire. À la suite de Braverman, nous considérons qu’il s’agit là d’un travail à part entière. Ses caractéristiques sont cependant différentes de celles du travail ouvrier. Si ce dernier relève de la biopolitique par le travail qu’il produit sur les corps, le travail gestionnaire relève d’une psychopolitique destinée à forger un nouvel individu défini par des habiletés, techniques, cognitives et surtout psychologiques. Assumant une position éducative, le journal Les Affaires publié au Québec à partir de 1928 entreprend, entre autres projets, de définir le travail gestionnaire et de produire ainsi un discours qui permet de légitimer la transformation capitaliste.

This article focuses on a type of work that has been studied very little: managerial work. Following Braverman, we consider it to be work in its own right. Its characteristics, however, are different from those of labour work. If the latter is biopolitics by the work it produces on the body, managerial work is psychopolitics designed to forge a new individual defined by skills, technical and cognitive, and above all psychological. Assuming an educational position, the newspaper, Les Affaires, published in Quebec from 1928, undertook, among other projects, to define managerial work, thus producing a discourse making it possible to legitimize capitalist transformation.
Settler Colonialism and Labour Studies in Canada
Authors: Camfield David 
Published: May 2019

The 21st century has seen growing attention to settler colonialism among academic researchers in Canada and internationally. In the Canadian context, interest has been fuelled above all by an ongoing resurgence of Indigenous activism and intellectual work, of which the most visible expression to most non-Indigenous people was the Idle No More movement of 2012–13. To date, however, little attention has been paid to settler colonialism within labour studies, broadly understood. As a modest contribution to remedying this deficiency, this article argues for the importance of understanding Canada as a settler-colonial society, proposes a conceptualization of settler colonialism from the perspective of a historical materialism reconstructed through engagement with Indigenous anticolonial thought, and offers some preliminary reflections on integrating analysis of settler colonialism into historical and contemporary research on labour.

Au 21e siècle, le colonialisme des colons a attiré de plus en plus l’attention des chercheurs universitaires canadiens et internationaux. Dans le contexte canadien, l’intérêt a été alimenté principalement par une résurgence continue du travail intellectuel et du militantisme autochtones, dont l’expression la plus visible pour la plupart des peuples non autochtones était le mouvement Idle No More de 2012–2013. À ce jour, toutefois, peu d’attention a été accordée au colonialisme des colons dans le cadre d’études sur le travail, au sens large. Cet article, qui contribue modestement à remédier à cette lacune, souligne l’importance de comprendre le Canada comme société de colonisation, propose une conceptualisation du colonialisme sous l’angle du matérialisme historique reconstruit à travers la confrontation avec la pensée anticoloniale offre des réflexions préliminaires sur l’intégration de l’analyse du colonialisme des colons dans la recherche historique et contemporaine sur le travail.
The Settler Order Framework
Authors: Burrill Fred 
Published: May 2019

Canadian labour and working-class history has, to a great extent, been bedevilled in its attempts to understand national trends by the cleavages of gender, region, industry, race, language, and culture. This article argues that one possible way out of this impasse lies in foregrounding the particular relationship between colonial exploitation and class exploitation in our settler colonial economy, both in terms of class formation and in the ongoing project of social reproduction. The adoption of a “settler order framework” seeks to build on important recent works attempting to understand Indigenous peoples’ participation in the ranks of those who toil, struggle, and dream of freedom from capitalism, by integrating the fundamental reality of settler workers’ ongoing theft of Indigenous land and resources into the story of the Canadian working class.

Au Canada, l’histoire du travail et de la classe ouvrière a été entravée, dans une large mesure, dans ses tentatives pour comprendre les tendances nationales, par les clivages liés au sexe, à la région, à l’industrie, à la race, à la langue et à la culture. Cet article soutient qu’une solution possible pour sortir de cette impasse consiste à mettre en évidence la relation particulière entre l’exploitation coloniale et l’exploitation de classe dans notre économie coloniale, à la fois en termes de formation de classe et dans le projet permanent de reproduction sociale. L’adoption d’un « cadre réglementaire pour les colons » s’appuie sur d’importants travaux récents qui tentent de comprendre la participation des peuples autochtones dans les rangs de ceux qui peinent, luttent et rêvent de se libérer du capitalisme, en intégrant la réalité fondamentale du vol de terres et de ressources autochtones par les travailleurs colons dans l’histoire de la classe ouvrière canadienne.
Exhibition Reviews
Authors: Mostafa Heba , Kashani Deanna 
Published: May 2019

THE WORLD OF THE FATIMIDS, AGA KHAN MUSEUM, TORONTO, CANADA, March 10–July 2, 2018
IN THE FIELDS OF EMPTY DAYS: THE INTERSECTION OF PAST AND PRESENT IN IRANIAN ART, LOS ANGELES COUNTY MUSEUM OF ART (LACMA), MAY 6–SEPTEMBER 9, 2018
EPITHELIAL NEOPLASMS OF THE CECAL APPENDIX
Authors: Costa Lineker Velozo , Araujo Moisés Ederlanio Tavares de , Batista Hermes Melo Teixeira , Nóbrega Edgley Almeida , Araújo Anna Clara Carvalho Curvina Costa de , Araújo Cicera Yolanda Dos Santos 
Published: May 2019

Cecal appendix carcinoma is characterized as an extremely rare condition and is found in only 1% of appendectomies and accounts for only 0.5% of neoplasms of the intestinal tract. The aim of the study is to discuss Appendix Carcinomatosis by presenting a case of Cecal Appendix Epithelial Neoplasm seen during the Surgery Residence. Keywords: Appendix Vermiformis, Acute Abdomen, Appendix Neoplasm.
Comparative Evaluation of The Efficacy Of Rotary file system (Kedo-S) Vs Hand K-Files In Root Canal Preparation Of Primary Teeth Using Cone Beam Computed Tomography (CBCT) - An In Vitro Study
Authors: Srinivas Abhinaya , Jeevanandan LGanesh , Govindaraju Lavanya , Subramanian Erulappan Muthu Ganapathi 
Published: May 2019

Objective: To evaluate the efficacy of rotary Kedo-S and hand K-files in shaping ability in primary canines using cone beam computed tomography. Materials and Methods: Thirty extracted primary maxillary and mandibular canines were selected. Using cone beam computed tomography the teeth were scanned before instrumentation. In Group I, the teeth were prepared using stainless steel K file up to the size of 40. In the Group II teeth, U1 size Kedo-S rotary file was used in crown down technique. The instrumented teeth were scanned again with cone beam computed tomography and the images were compared. Results: The canal taper was more conical for rotary Kedo-S files as compared to K-files, which was statistically significant. Conclusion: Canal preparation with Rotary files resulted in more conical canals when compared to manual instrumentation in primary teeth that contributes to more uniform obturation.KeywordsCBCT; Hand K-files; Kedo-S file system; Primary teeth; Pulpectomy; Rotary instrumentation.