bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Soft Skills Peserta Didik pada Pembelajaran Redoks dengan Model Flipped Classroom-Collaborative Learning
Authors: Paristiowati Maria , Yusmaniar Yusmaniar , Darojatun Catur Ahda 
Published: February 2019

Penelitian ini bertujuan untuk mengetahui soft skills peserta didik pada pembelajaan materi redoks dan tata nama senyawa kimia dengan model flipped classroom-collaborative learning. Penelitian dilakukan di salah satu SMA Negeri di Jakarta dengan 36 peserta didik kelas X sebagai subyek penelitian. Metode penelitian yang digunakan adalah metode penelitian kualitatif dengan menggunakan instrumen wawancara, lembar observasi, reflektif jurnal, catatan lapangan, kuesioner serta tes hasil belajar. Flipped classroom-collaborative learning adalah model pembelajaran dimana peserta didik mempelajari materi pelajaran di luar kelas melalui video pembelajaran, dan kegiatan belajar di dalam kelas dilakukan dengan pembelajaran kolaboratif yang menekankan pada aktivitas peserta didik dalam kelompok, meliputi kerja sama, sharing knowledge, mengkonstruksi pemahaman bersama, dan bertanggung jawab terhadap kelompok. Hasil penelitian menunjukkan soft skills peserta didik yang muncul meliputi keterampilan komunikasi, keterampilan kolaborasi dan literasi teknologi informasi dan komunikasi (TIK). Penerapan model flipped classroom-collaborative learning memberikan kemudahan bagi peserta didik untuk memahami materi pelajaran di dalam maupun di luar kelas, mereview materi pelajaran, membantu peserta didik yang pasif, dan dapat digunakan sebagai panduan dalam mengerjakan tugas serta mempersiapkan tes. Selain itu, model pembelajaran ini juga berdampak positif terhadap hasil belajar peserta didik.
Kata kunci : Flipped classroom, Collaborative learning, Soft skills, Redoks
Analisis Laboratory Jargon dan Miskonsepsi dalam Materi Asam-Basa
Authors: Hadinugrahaningsih Tritiyatma , Zahia Belgys , Rahmawati Yuli , Kartika Irma Ratna 
Published: February 2019

Penelitian ini bertujuan untuk menganalisis Laboratory Jargon dan miskonsepsi dalam materi asam-basa pada siswa SMA kelas XI. Subjek penelitian ini adalah siswa kelas XI IPA di lima SMA pada kecamatan Pulogadung, Jakarta Timur sebanyak 320 siswa.. Metode Penelitian yang digunakan adalah metode survei kuantitatif. Data penelitian diperoleh melalui observasi saat pembelajaran, jawaban siswa pada Kuesioner Laboratory Jargon, dan wawancara siswa. Miskonsepsi yang dibahas pada penelitian ini terkait dengan beberapa konsep pada materi asam-basa, yaitu konsep atom dan molekul; definisi asam basa; disosiasi air; asam-basa lemah; konsentrasi air; pembentukan ion asam-basa; reaksi netralisasi; kekuatan asam (pH); indikator asam basa; serta sifat amfoter air. Hasil dari penelitian menunjukan bahwa dari sepuluh konsep tersebut masih banyak siswa yang memilih jawaban Laboratory Jargon yang merupakan pernyataan miskonsepsi. Persentase miskonsepsi siswa rata-rata dari sepuluh konsep tersebut adalah 64,44%. Persentase miskonsepsi siswa yang paling besar adalah pada konsep sifat amfoter air yaitu 85,31% kemudian konsep kekuatan asam (pH) yaitu 75,62%. Berdasarkan hasil wawancara sebagian besar siswa memilih jawaban miskonsepsi disebabkan karena siswa terbiasa mempelajari suatu konsep kimia dengan Laboratory Jargon baik dari guru atau sumber belajar.
Kata kunci
Laboratory Jargon, miskonsepsi, asam-basa, survei
Clinical and radiological factors predict unexplained early neurological deterioration after intravenous thrombolysis in patients with acute middle cerebral artery stroke
Authors: Ding Yiping , Sun Tong , Lu Yue , Huang Shuangjiao , Diao Shanshan , Li Tan , Zhu Juehua , Fang Qi , Cai Xiuying , Xu Zhuan , Kong Yan 
Published: February 2019

Abstract
Background

Some patients with acute middle cerebral artery stroke (MCA-stroke) cannot benefit from thrombolysis and develop early neurological deterioration (END) within 24 hours. Except for several defenitive causes such as symptomatic intracerebral hemorrhage, malignant edema, and early recurrent stroke, no definitive mechanism (unexplained END) account for majority of END cases deserving our attention.

Methods

We retrospectively collected 142 MCA-stroke patients who had pretreatment multimodal CT including non-contrast CT (NCCT), CT angiography (CTA) and CT perfusion (CTP) and received intravenous thrombolytic therapy within 4.5h of onset and. Unexplained END was denited as NIHSS scores increased from baseline within 24 hours after thrombolysis ≥ 4 points or death without definite causes. The clinical and imaging data based on multimodal CT were compared between unexplained END and no END through univariate and multivariate regression analyses.

Results

The prevalence of unexplained END (24 patients, 16.9%) outnumbered the prevalence of END due to other causes. Univariate analysis showed that higher admission glucose (P= 0.039), lower initial NIHSS score (P=0.026), lower r-LMC score (P= 0.003), proximal occlusion (P=0.003) and large penumbra volume(P<0.001) were more frequently observed in patients with unexplained END; In multivariate analysis, lower NIHSS score (OR=1.19; 95% CI, 1.07-1.32; P=0.001), proximal occlusion (OR=0.32; 95% CI, 0.06-0.92; P=0.038), lower r-LMC score (OR=1.17; 95% CI, 1.02-1.35; P=0.028) and larger penumbra volume (OR=0.98; 95% CI, 0.96-0.99; P=0.003) were associated with unexplained END.

Conclusion

Lower NIHSS score, proximal occlusion, lower r-LMC score and larger penumbra volume can predict unexplained END in the hyperacute phase of MCA-stroke and contribute to develop treatment strategies.
BIM-Based Facility management for water treatment plants using laser scanning
Authors: Marzouk Mohamed , Ahmed Rasha 
Published: February 2019

Abstract
Lack of maintenance information pertaining to water treatment plant equipment may lead to many problems within the treatment system and affect its performance. A framework for using three-dimensional laser scanning to obtain equipment maintenance information for water treatment plants is presented. The framework core phase involves automation of information exchange in a three-dimensional computer-aided design (CAD) environment as the foundation for adopting a Building Information Modeling (BIM) approach. The framework supports the concepts of BIM-based facility management through the essential task of equipment information clustering according to maintenance intervals. Clustering according to daily, weekly, monthly, and annual maintenance plans are identified with potential applicability for additional extentions. Finally, a case study illustrates the benefits of using laser scanning technology in facility management.
Astaxanthin Combine with Human Serum Albumin to Abrogate Cell Proliferation, Migration, and Drug-resistant in Human Ovarian Carcinoma SKOV3 Cells
Authors: Su Xiu-Zhen , Chen Ran , Wang Cai-Bing , Ouyang Xi-Lin , Jiang Yan , Zhu Ming-Yi 
Published: February 2019

Background:
Astaxanthin (AST) shows a large range of beneficial effects together with anti-cancer
and antioxidation properties. Human Serum Albumin (HSA) is the most abundant protein in blood plasma which
plays the role of a depot and transport protein for many exogenous compounds. However, whether HSA could
enhance AST-induced cytotoxic effects in human ovarian cancer cells has not been examined to date.

Objective:
This study aims to explore the anticancer effect and the molecular mechanism of AST combine with
HSA induced cytotoxicity in ovarian cancer SKOV3 cells.

Methods:
The ovarian cancer SKOV3 cells were treated by AST combined with HSA to study the effects of cell
proliferation, cell morphology, cell cycle arrest, related protein expression, nuclear transfer, cell migration, and
drug-resistant.

Results:
Our data confirmed that AST+HSA treatment enhanced the anticancer effects of AST, arrested G1
phase cell cycle and induced apoptosis in SKOV3 cells. AST+HSA induced apoptosis via mitochondrial apoptotic
pathways was related to the increased ratio of Bcl-2/Bax and activation of caspase-3. Besides, exposure of
cells to AST+HSA triggered the inactivation of NF-κB and activation p53 and MAPKs signaling pathways.
Furthermore, AST+HSA significantly overcome the drug-resistant and inhibited the migration of SKOV3 cells.

Conclusion:
AST combined treatment with HSA considerably inhibited NF-κB expression and translocation to
nucleus, thereby improving the AST-induced cytotoxic effect on SKOV3 cells. These findings may provide
rationale to combine AST with HSA for the treatment of ovarian cancer.
Screening of NO Inhibitor Release Activity from Soft Coral Extracts Origin Palu Bay, Central Sulawesi, Indonesia
Authors: Tanod Wendy Alexander , Yanuhar Uun , Maftuch  , Putra Masteria Yunovilsa , Risjani Yenny 
Published: February 2019

Background:
As a marine organism, soft corals can be utilized to be various
bioactive substances, especially terpenoids and steroids. The soft corals family which produces
bioactive generally come from clavulariidae, alcyoniidae, nephtheidae and xeniidae
family.

Objective:
To investigate the bioactivity of Nitric Oxide (NO) inhibitor release from soft
coral crude extracts of Sinularia sp. (SCA), Nephthea sp. (SCB), Sarcophyton sp. (SCC),
Sarcophyton sp. (SCD), Sinularia sp. (SCE) and Sinularia sp. (SCF).

Materials and Methods:
Soft coral is collected from Palu Bay (Central Sulawesi). NO inhibitory
release activity measured according to the Griess reaction. Soft corals sample
macerated with 1:2 (w/v). Then, Soft coral extracts with the best NO Inhibitor activity partitioned
with Dichloromethane, Ethyl acetate, and n-butanol. The bioactive of all crude extracts
were identified by GC-MS to find compounds with anti-inflammatory potential.

Results:
Sarcophyton sp. (SCC) and Sinularia sp. (SCF) are able to inhibit NO concentrations
of 0.22 ± 0.04 and 0.20 ± 0.04 µM at 20 mg/mL, respectively. The chemical constituents
determined and showed the potential as anti-inflammatory in the crude of Sinularia sp.
(SCA) were Octacosane (3.25%). In Nephthea sp., (SCB) were Cyclohexene, 6-ethenyl-6-
methyl-1-(1-methylethyl)-3-(1-methylethylidene)-,(S)- (0.55%); Azulene, 1,2,3,4,5,6,7,8-
octahydro-1,4-dimethyl-7-(1-methylethylidene)-, (1S-cis)- (0.53%); and 1,7,7-Trimethyl-
2-vinylbicyclo[2.2.1]hept-2-ene (4.72%). In Sarcophyton sp, (SCC) were Eicosane
(0.12%); Nonacosane (10.7%); 14(β)-Pregnane (0.87%); Octacosane 6.39%); and Tricosane
(1.53%). In Sarcophyton sp. (SCD) were 14(β)-Pregnane (2.69%); and Octadecane
(27.43%). In crude of Sinularia sp. (SCE) were Oleic Acid (0.63%); 7,10-Hexadecadienoic
acid, methyl ester (0.54%); 14(β)-Pregnane (1.07%); 5,8,11,14-Eicosatetraenoic acid, ethyl
ester, (all-Z)- (4.60%); Octacosane (7.75%); and 1,2-Benzisothiazole, 3-(hexahydro-1Hazepin-
1-yl)-, 1,1-dioxide (1.23%). In the crude of Sinularia sp., (SCF) were Oxirane,
decyl- (1.38%); Nonacosane (0.57%); Cyclohexanol, 5-methyl-2-(1-methylethenyl)-
(0.61%); 14B-Pregnane (0.76%); and Tetratriacontane (1.02%).

Conclusion:
The extract of Sarcophyton sp. (SCC) and Sinularia sp. (SCF) showed the
best NO inhibitory release activity. This study is making soft corals from Central Sulawesi,
Indonesia can become a potential organism in the discovery and development of bioactive
substances anti-inflammatory.
In Silico (3D-QSAR) Designed, Study, Synthesis and Anti-tubercular Evaluation of Pyrazolo-Pyrimidine Derivatives
Authors: Chhatbar Pratiksha , Pambhar Kaushik , Khedkar Vijay , Shah Anamik , Khunt Ranjan 
Published: February 2019

Background:
A 3D-QSAR study based on CoMFA and CoMSIA was performed on
these pyrazole-pyrimidine derivatives to correlate their chemical structures with the observed activity
against M. tuberculosis.

Objective:
The current research aimed to synthesize and evaluateed pyrazole-pyrimidine based
antitubercular agents by an in vitro microbial study based on our previously reported 3D-QSAR.

Methods:
The designed molecules were synthesised via chalcone intermediate and cyclisation using
guanidine and urea. The molecules were then characterized by various spectroscopic methods
like IR, MASS, 1H-NMR, 13C-NMR and in vitro evaluation against M. tuberculosis H37Rv. They
were further evaluated under anaerobic condition and their intracellular assay was studied. The
compounds were further examined for cytotoxicity towards eukaryotic cells.

Results:
Compounds 3a, 3c and 3i were found to be the most effective against M. tuberculosis
H37Rv, with IC50 of 16μM, 13μM and 15μM, respectively.

Conclusion:
The designed strategy, to enhance the antitubercular activity against M. tuberculosis
H37Rv, was proved fruitful. On considering the overall data, the promising results would be useful
to design the next target with improved efficacy and potency of compounds for further medicinal
importance.
TIPO DE CAMBIO REAL Y VENTAJA ABSOLUTA DE COSTO: ESPAÑA, 2000-2014
Authors: Boundi Chraki Fahd 
Published: February 2019

<p align="center"><strong>RESUMEN</strong></p><p>En esta investigación se busca contrastar la hipótesis de que el tipo de cambio real efectivo entre los sectores manufactureros de España y el de sus socios de la Unión Europea se encuentra regulado, en el periodo 2000-2014, por los costos laborales unitarios verticalmente integrados relativos y las diferencias intrasectoriales de la tasa de ganancia. Utilizando técnicas de cointegración en datos de panel, los resultados apuntan a que entre las tres variables existe una relación estable en el largo plazo. De igual manera, los vectores de cointegración indican que la posición competitiva de los sectores manufactureros españoles está asociada de forma positiva con la disminución de los costos unitarios de producción, en tanto que se relaciona de forma negativa con el incremento de la brecha de rentabilidad intrasectorial.</p><p> </p><p align="center"><strong>REAL EXCHANGE RATE AND ABSOLUTE COST ADVANTAGE: SPAIN, 2000-2014</strong></p><p align="center"><strong>ABSTRACT</strong></p>This research is aimed to test the hypothesis that the real effective exchange rate between Spain’s manufacturing sectors and its European Union partners has been governed by the relative vertically integrated unit labor costs and the intrasectoral differences of the profit rate during 2000-2014. Using panel cointegration techniques, the results suggest that there exists a stable long-run relationship between those three variables. Likewise, cointegration vectors indicate that the Spanish manufacturing competitiveness is positively associated with the decrease in unit costs of production, while it is negatively related to the increase in the intrasectoral profitability gap.
PENINGKATAN KECERDASAN KINESTETIK MENGGUNAKAN MODIFIKASI PERMAINAN PADA LESSON STUDY DI SD MOH HATTA MALANG
Authors: Arifin Bustanol , Fantiro Frendy Aru , Ulum Bahrul 
Published: February 2019

Abstrak: Pelaksanaan lesson study ini memiliki tujuan yaitu meningkatkan kecerdasan kinestetik menggunakan modifikasi permainan pada kelas 4 di SD Moh. Hatta Malang. Penelitian ini merupakan penelitian deskriptif dengan mengimplementasikan lesson study. Adapun subyek penelitian adalah peserta didik kelas 4 di SD Moh. Hatta Malang Pengimplementasian lesson study ini dilakukan dalam 4 kali putaran. Tahapan pelaksanaan LS terdiri dari 3 tahapan yaitu: (1) tahap perencanaan (plan), (2) Tahap pelaksanaan (do), serta (3) tahap refleksi (see). Kecerdasan Kinestetik siswa kelas 4 SDN Moh Hatta Data rata-rata nilai siswa pada matapelajaran PJOK pada siklus I 72,5; siklus II 77,13 dan siklus III 78,5. Siklus IV 81,7 Peningkatan dari siklus I ke siklus II 4,63; siklus II ke siklus III 1,37. Siklus III ke IV 3, 25 Lesson study menyebabkan siswa bersemangat, dalam melakukan kegiatan pembelajaran dan merasa senang sehingga hasil kemampuan gerak kinestetik paserta didik dari siklus I ke siklus IVmeningkat. Kata Kunci: kecerdasan kinestetik, modifikasi permainan, sekolah dasarAbstract: The implementation of this lesson study has the aim of improving kinesthetic intelligence using game modification in grade 4 in Moh. Hatta primery school. This research is a descriptive research by implementing lesson study. The subjects of the study were 4th grade students in Moh. Hatta primery school. The implementation of this lesson study was conducted in 4 rounds. The stages of LS implementation consist of 3 stages: (1) planning stage, (2) Implementation stage (do), and (3) stage of reflection (see). Kinesthetic Intelligence of grade 4 students in Moh Hatta Primary School Average data on student score on Physchal Education learning in cycle I 72,5; cycle II 77.13 and cycle III 78.5. Cycle IV 81,7 Increase from cycle I to cycle II 4.63; cycle II to cycle III 1.37. Cycle III to IV 3, 25 Lesson study causes the students to be excited, in doing the learning activities and feel happy so that the result of kinesthetic ability of the students from cycle I to cycle IV can increased. Keywords: kinesthetic intelligence, game modification, elementary school
Long-Run Career Consequences for Andersen's Putative Partners
Authors: Sellers R. Drew , Fogarty Timothy J. 
Published: February 2019

ABSTRACT
The sudden collapse of Arthur Andersen & Co. (Andersen) in 2001–2002 altered the careers of many professionals who were employed by that international accounting firm. Now that many years have passed since that event, some long-run consequences can be quantified. This paper examines the subsequent careers of 267 managers employed by Andersen at that time in seven Midwestern U.S. cities. Benchmarking these results against similarly situated individuals at another large firm, we conclude that ex-Andersen managers were much less likely to continue in large firm employment, stay in public accounting, or achieve partnership status in the profession. However, the professional networks maintained by ex-Andersen people many years after that firm's collapse appear as strong as that of the control sample.
Data Availability: Data are available from the first author upon request.
Conservatism in Accounting: A Reassessment
Authors: Bloom Robert 
Published: February 2019

ABSTRACT
This paper examines how the concept of “conservatism” evolved in historical and contemporary accounting writings using authoritative professional and academic documents. The paper reviews the application of conservatism in the FASB and IASB conceptual frameworks. A brief discussion of empirical research on conservatism is provided. Finally, the paper looks at the declining influence of conservatism in private company accounting principles in three selected countries: Belgium, Switzerland, and Japan. Conservatism is found to be a perennial issue in accounting practice and accounting standard setting. This concept has long been embedded in private company accounting in different countries. Its rationale, along with its conflict with neutrality have been debated for centuries.
La contabilidad como plataforma de gestión del talento humano en las organizaciones empresariales
Authors: Elizalde-Marín Letty 
Published: February 2019

Con el objetivo de analizar la contabilidad como plataforma de gestión del talento humano en las organizaciones empresariales, se realiza una investigación documental con diseño bibliográfico, soportada por la revisión en profundidad de cada una de las categorías, así como unidades de análisis del tema seleccionado, lo cual permite la recolección de información de distintas fuentes, sobre una muestra constituida por elementos de referencia teórica. Para luego extraer a través de una matriz previamente formulada la información examinada, conformada por aspectos que soportan implícita o explícitamente las conceptualizaciones de contabilidad, finanzas, activos intangibles, gestión del talento humano, gestión del conocimiento, capital intelectual y métodos para medirlo, así como organizaciones empresariales. Concluyendo que la contabilidad está articulada y guarda correspondencia con la gestión del talento humano de cualquier organización, por lo tanto de manera efectiva requiere involucrar en sus procesos la medición del capital intelectual generado, como parte de los eventos económicos acometidos en un momento determinado. En este sentido, en la investigación fue viable explorar los diferentes métodos utilizados para el reconocimiento de estos activos intangibles, como parte de la funcionabilidad de la empresa, considerando que los cambios ocurridos en la economía mundial, llevan a sostener la condición del conocimiento como un elemento fundamental de la escena económica global, en consecuencia no resulta extraño, ni algo ajeno al desenvolvimiento organizacional, que los diferentes niveles contables de las empresas se encuentren interesados en controlar y gestionar el referido factor.
Pharmacokinetics after subcutaneous administration of a single dose of cefovecin sodium in African lions (Panthera leo)
Authors: Flaminio Kelly P. , Christensen John Mark , Alshahrani Sultan Mohammed , Mohammed Sumeia Mohammed 
Published: February 2019

Abstract
OBJECTIVE To determine the pharmacokinetics of cefovecin sodium after SC administration of a single dose to African lions (Panthera leo).
ANIMALS 3 adult (9 to 10 years old; 1 male and 2 females) and 3 juvenile (2 years old; 1 male and 2 females) African lions.
PROCEDURES A crossover study was conducted. A single dose of cefovecin was administered SC at 4 mg/kg (half dose) and 8 mg/kg (full dose) to African lions. Blood samples were collected daily for 14 days after cefovecin injection. Plasma drug concentrations were determined by use of high-performance liquid chromatography with UV detection.
RESULTS Cefovecin had first-order elimination kinetics for doses of 4 and 8 mg/kg. Mean ± SD maximum plasma concentration was 9.73 ± 1.01 μg/mL and 18.35 ± 0.94 μg/mL after doses of 4 and 8 mg/kg, respectively. Time to maximum plasma concentration was approximately 4 hours for both doses. Mean elimination half-life was approximately 111 and 115 hours after doses of 4 and 8 mg/kg, respectively.
CONCLUSIONS AND CLINICAL RELEVANCE Cefovecin was detected in lion plasma for 336 hours after administration at both 4 and 8 mg/kg at concentrations greater than the reported minimum inhibitory concentration (0.06 μg/mL) for common bacterial organisms in domestic cats. These results indicated that cefovecin administered at 4 mg/kg SC reached therapeutic concentrations for an extended period in African lions.
Ex vivo computed tomography evaluation of loading position on morphometry of the caudal cervical intervertebral disk spaces of dogs
Authors: Knell Sebastian C. , Smolders Lucas A. , Steffen Thomas , Pozzi Antonio 
Published: February 2019

Abstract
OBJECTIVE To provide an objective, quantitative morphometric description of the caudal cervical intervertebral disk (IVD) spaces of dogs.
SAMPLE Vertebral specimens consisting of C4 through C7 from 5 medium-sized dogs.
PROCEDURES CT images were obtained with the specimens positioned in neutral, flexion, extension, and lateral bending positions. Size and shape of the cranial and caudal end plates, angle between the end plates (IVD wedge angle), and craniocaudal distance (IVD width) between end plates for the 4 loading positions were measured and compared for the 3 segments (C4-5, C5-6, and C6-7).
RESULTS End plate size and shape, IVD wedge angle, and IVD width were not significantly different among the 3 segments. Caudal cervical end plates were consistently larger than cranial cervical end plates. The IVD wedge angle ranged from −4.8° to 15.2°. Flexion induced a reduction in IVD width in the ventral portion of the IVD, whereas extension induced a decrease in width in the dorsal portion of the IVD. Central IVD width remained unchanged among the loading positions.
CONCLUSIONS AND CLINICAL RELEVANCE Unique morphometric and dynamic characteristics of the caudal cervical IVD space of dogs were detected. These findings may help investigators when designing IVD prostheses for dogs with cervical spondylomyelopathy.