bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily Electrocardiogram Electrode Change and the Effect on Frequency of Nuisance Alarms
Authors: Shue McGuffin Katherine , Ortiz Sheri 
Published: May 2019

Background
In 2018, The Joint Commission identified false telemetry alarms as a significant technology hazard placing patients at risk of injury. Reasons include poor skin preparation when applying electrodes and improper placement of electrodes.

Objectives
The purpose of this quality improvement project was to determine if changing electrocardiogram electrodes daily would decrease the frequency of nuisance alarms.

Methods
Study design was quantitative/comparative on all patients receiving telemetry monitoring on a 36-bed adult inpatient cardiac telemetry unit. Data collection occurred for 14 days before the intervention and 14 days during the intervention of daily electrode change. Comparison analysis determined if frequency of alarms decreased after the intervention with daily electrode change.

Results
Postintervention data showed a 74.15% reduction in telemetry alarms following implementation of a daily electrode change.

Discussion
Daily electrocardiogram electrode changes may be an effective strategy for reducing nuisance alarms on telemetry units. Outcomes can be used in conjunction with existing evidence to drive current practice.
Nipple Reconstruction: A Novel Triple Flap Design
Authors: Krogsgaard Sofie H.H. , Carstensen Lena F. , Thomsen Jørn B. , Rose Michael 
Published: May 2019

Background:
Restoring the nipple–areola complex completes the breast reconstructive process. Local flaps are often used for the nipple reconstruction; however, the number of techniques indicates the lack of a superior design. The aims of this study were to test the feasibility of a new triple flap design for nipple reconstruction and to evaluate complication rate and nipple projection.

Methods:
From November 2015 to November 2018, we performed the triple flap nipple reconstruction guided by a template for preoperative mark-up. Patients were followed up postoperatively to evaluate healing and signs of complications including wound dehiscence, infection, and flap necrosis, and nipple projection. The areola was tattooed 3 months postoperatively.

Results:
Twenty-six nipple reconstructions were successfully performed in 22 women. Four nipple reconstructions (15%) were performed in irradiated tissue. One reconstruction had a superficial infection, while there were no cases of wound dehiscence or flap necrosis. Three nipple reconstructions (12%) experienced prolonged healing that did not require intervention. None of these reconstructions had received radiation therapy. The nipple projection was 7.3 mm (range 6–9 mm) at the time of surgery and 3.1 mm (range 0–6 mm), 2.5 mm (range 2–3 mm), and 1.6 mm (range 0–3 mm) at follow-up of 3, 6, and 12 months, respectively.

Conclusions:
We present the new triple flap design for nipple reconstruction guided by a template for mark-up. The preliminary results indicate a low complication rate in both irradiated and nonirradiated patients while sustaining the projection over time remains to be a challenge.
Use of Acellular Dermal Matrix Following Fasciectomy for the Treatment of Dupuytren’s Disease
Authors: Hoang Don , Steven Patrick , Chen Vivi W. , Stasiak Ashley , Cohen Myles , Kulber David A. 
Published: May 2019

Background:
Recurrence rates following surgical intervention for Dupuytren's disease (DD) remains high. In this study, we investigate the use of acellular dermal matrix (ADM) to reduce recurrence and improve long-term clinical outcome.

Methods:
We examined 132 patients undergoing open fasciectomy for DD from 2007 to 2017. The experimental group had a sheet of ADM (FlexHD) sutured into the surgical bed controls were not closed with ADM. Patient characteristics, range of motion, and complications were examined.

Results:
Twenty-eight (21.2%) patients were treated with acellular dermal matrix, whereas 104 (78.8%) patients were not. The median age was 67.0 years (range 34–91 years). with no differences between group regarding age, comorbidities, and laterality. The mean preoperative interphalangeal joint flexion contracture in the ADM group of 66.5 ± 29.9 degrees was corrected to 9.7 ± 12.4 degrees, whereas the mean metacarpophalangeal joint preoperative flexion contracture of 51.4 ± 23.9 degrees was corrected to 7.8 ± 14.1 degrees at postoperative examination (P < 0.05). The median follow-up was 18.7 months, during which the recurrence of contracture was observed in 1 of 28 patients in the group receiving ADM compared with 9 of 104 in the control group (P = 0.37). There were no differences in the incidence of minor wound complications observed.

Conclusion:
The adjunct placement of acellular dermal matrix into the wound bed following fasciectomy for DD may be an important surgical strategy to reduce recurrence rates as well as augment coverage of exposed vital structures in cases of severe flexion contracture.
Hyperspasticity After Partial Neurectomy for Treatment of Myospasms Following Subpectoral Breast Reconstruction
Authors: Mamsen Frederik P. , Carstensen Lena F. 
Published: May 2019

Summary:
Breast reconstruction using tissue expander is a frequently used method of reconstruction after mastectomy. We describe a rare complication of myospasms after subpectoral tissue expander reconstruction with acellular dermal matrix. The patient gradually developed disturbing pectoral muscle spasms lasting almost a year. Botulinum toxin A was undesired due to its transient effect. Selective denervation of the medial pectoral nerve branches was performed and resulted in worse spasms where the breast bounced at a rapid speed. Complete denervation of the pectoral nerves led to immediate liberation. We recommend a cranial denervation of both medial and lateral pectoral nerves to secure complete denervation leading to permanent relief of involuntary spasms where selective denervation may lead to hyperspasticity.
High-dose prescribed opioids are associated with increased risk of heroin use among United States military veterans
Authors: Banerjee Geetanjoli , Edelman E. Jennifer , Barry Declan T. , Crystal Stephen , Gordon Kirsha S. , Gordon Adam J. , Gaither Julie R. , Green Traci C. , Kerns Robert D. , Manhapra Ajay , Moore Brent A. , Fiellin David A. , Marshall Brandon D.L. 
Published: May 2019

Abstract
Despite evidence linking increased risk of opioid use disorder with specific opioid-prescribing patterns, the relationship between these patterns and heroin use is less understood. This study aimed to determine whether dose and duration of opioid prescriptions predict subsequent heroin use in United States veterans. We analyzed data from 2002 to 2012 from the Veterans Aging Cohort Study, a prospective cohort study. We used inverse probability of censoring weighted Cox regression to examine the relationship between self-reported past year heroin use and 2 primary predictors: (1) prior receipt of a high-dose opioid prescription (≥90 mg morphine equivalent daily dose), and (2) prior receipt of a long-term opioid prescription (≥90 days). Heroin use was ascertained using most recent value of time-updated self-reported past year heroin use. Models were adjusted for HIV and hepatitis C virus infection status, sociodemographics, pain interference, posttraumatic stress disorder, depression, and use of marijuana, cocaine, methamphetamines, and unhealthy alcohol use. In the final model, prior receipt of a high-dose opioid prescription was associated with past year heroin use (adjusted hazard ratio use = 2.54, 95% confidence interval: 1.26-5.10), whereas long-term opioid receipt was not (adjusted hazard ratio = 1.09, 95% confidence interval: 0.75-1.57). Patients receiving high-dose opioid prescriptions should be monitored for heroin use. These findings support current national guidelines recommending against prescribing high-dose opioids for treating pain.
DNA methylation profiles are associated with complex regional pain syndrome after traumatic injury
Authors: Bruehl Stephen , Gamazon Eric R. , Van de Ven Thomas , Buchheit Thomas , Walsh Colin G. , Mishra Puneet , Ramanujan Krishnan , Shaw Andrew 
Published: May 2019

Abstract
Factors contributing to development of complex regional pain syndrome (CRPS) are not fully understood. This study examined possible epigenetic mechanisms that may contribute to CRPS after traumatic injury. DNA methylation profiles were compared between individuals developing CRPS (n = 9) and those developing non-CRPS neuropathic pain (n = 38) after undergoing amputation following military trauma. Linear Models for Microarray (LIMMA) analyses revealed 48 differentially methylated cytosine-phosphate-guanine dinucleotide (CpG) sites between groups (unadjusted P's < 0.005), with the top gene COL11A1 meeting Bonferroni-adjusted P < 0.05. The second largest differential methylation was observed for the HLA-DRB6 gene, an immune-related gene linked previously to CRPS in a small gene expression study. For all but 7 of the significant CpG sites, the CRPS group was hypomethylated. Numerous functional Gene Ontology-Biological Process categories were significantly enriched (false discovery rate-adjusted q value <0.15), including multiple immune-related categories (eg, activation of immune response, immune system development, regulation of immune system processes, and antigen processing and presentation). Differentially methylated genes were more highly connected in human protein–protein networks than expected by chance (P < 0.05), supporting the biological relevance of the findings. Results were validated in an independent sample linking a DNA biobank with electronic health records (n = 126 CRPS phenotype, n = 19,768 non-CRPS chronic pain phenotype). Analyses using PrediXcan methodology indicated differences in the genetically determined component of gene expression in 7 of 48 genes identified in methylation analyses (P's < 0.02). Results suggest that immune- and inflammatory-related factors might confer risk of developing CRPS after traumatic injury. Validation findings demonstrate the potential of using electronic health records linked to DNA for genomic studies of CRPS.
Persistent opioid use is associated with worse survival after lobectomy for stage I non-small cell lung cancer
Authors: Nelson David B. , Cata Juan P. , Niu Jiangong , Mitchell Kyle G. , Vaporciyan Ara A. , Antonoff Mara B. , Hofstetter Wayne L. , Giordano Sharon H. , Sepesi Boris , Mehran Reza J. , Rice David C. 
Published: May 2019

Abstract
The incidence of persistent opioid use after lung surgery is high. Although adverse effects by opioids have been well described, it is unknown whether persistent opioid use is associated with worse survival. Patients who received a lobectomy for stage I NSCLC from 2007 to 2013 were identified from the Surveillance, Epidemiology and End Results-Medicare database. Opioid use was ascertained through records of prescriptions filled through part D. Patients were matched 2:1 according to their likelihood of persistent opioid use, which was defined as any opioid prescription filled 3 to 6 months after surgery. Two thousand eight hundred eighty-four patients were identified. The incidence of persistent opioid use 3 to 6 months after surgery was 27.0%. After matching, persistent opioid use was associated with worse overall survival (P < 0.001) and cancer-specific survival (P < 0.001). Those who used the lowest quartile of opioids, which was often manifested as a single opioid prescription, showed similar overall survival as no opioid use (HR 1.27, 95% confidence interval [CI] 0.93-1.72). However, the second and third quartiles of opioid use were associated with decreased overall survival (HR 1.53, 95% CI 1.14-2.03 and HR 1.39, 95% CI 1.04-1.86, respectively) that was nonetheless less severe than the highest quartile of opioid use (HR 2.50, 95% CI 1.95-3.21). Age, sex, marital status, comorbidity, tumor size, tumor grade, and radiation were also associated with worse overall survival, with chemotherapy use and video-assisted thoracoscopic surgery being associated with improved overall survival. Persistent opioid use 3 to 6 months after lobectomy is independently associated with worse overall survival and worse cancer-specific survival.
Effect of topical application of adrenaline on Schlemm canal, trabecular meshwork and intraocular pressure
Authors: Ye Meng , Chen Zhiqi , Li Mu , Chen Wei , Zhang Hong , Wang Junming 
Published: May 2019

Abstract

Aim:
To measure changes in the sizes of Schlemm canal (SC) and trabecular meshwork (TM) in healthy individuals before and after topical application of 1% adrenaline at 15, 45, and 90 minutes using anterior segment optical coherence tomography (ASOCT).

Methods:
Anterior chamber angle imaging of the nasal and temporal regions of the right eyes was performed with anterior segment optical coherence tomography (ASOCT) before and after topical application of 1% adrenaline at 15, 45, and 90 minutes. The diameter and area of SC, width and thickness of TM, anterior chamber depth (ACD) and pupil diameter (PD) were measured with ASOCT images. Intraocular pressure (IOP) was also recorded simultaneously.

Results:
A total of 15 healthy individuals were enrolled and included 7 male subjects and 8 female subjects; Compared with the parameters before intervention, both the SC diameter and area in the 2 quadrants increased after the application of adrenaline at the 3 time points (P < .05). The TM width increased after medication (P < .05). IOP decreased significantly after application (P < .05). There were no statistically significant changes in TM thickness, ACD, and PD at any point of time (P > .05).

Conclusion:
Topical application of 1% adrenaline in eye led to decrease in IOP with the SC diameter and area as well as the TM width increased after medication. While the TM thickness, ACD, PD seemed to remain constant.
The effect of air pollution on hospitalization of individuals with respiratory and cardiovascular diseases in Jinan, China
Authors: Chen Cai , Wang Xianfeng , Lv Chenguang , Li Wei , Ma Dedong , Zhang Qi , Dong Leilei 
Published: May 2019

Abstract
To analyze the short-term effects of air pollution on the hospitalization rates of individuals with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), stroke, and myocardial infarction (MI) after adjusting for confounding factors including weather, day of the week, holidays, and long-term trends in Jinan, China.
Hospitalization information was extracted based on data from the primary class 3-A hospitals in Jinan from 2013 to 2015. The concentrations of PM2.5, PM10, SO2, NO2, and O3 were obtained from Jinan Environment Monitoring Center. The relative risk and 95% confidence intervals of AECOPD, stroke, and MI were estimated using generalized additive models with quasi-Poisson distribution in the mgcv package, using R software, version 1.0.136.
The incremental increased concentrations of particulate pollutants including PM2.5 and PM10 were significantly associated with increased risk of hospitalization of AECOPD, stroke, and MI, and the adverse influences of PM2.5 on these diseases were generally stronger than that of PM10. The incremental increased concentrations of gaseous pollutants including SO2, NO2, and O3 were significantly associated with increased risk of hospitalization of stroke and MI in this population.
Air pollution has significant adverse effects on hospitalization rates of individuals with AECOPD, stroke, and MI in Jinan, China.
Effectiveness and safety of Danshen injection on heart failure
Authors: Yuan Tianhui , Chen Yi , Zhou Xiaoqi , Lin Xueying , Zhang Qingsong 
Published: May 2019

Abstract

Background:
Danshen injection (DSI) is a traditional Chinese medicine preparation extracted from Danshen (Salvia miltiorrhiza), which has the functions of promoting blood circulation and removing blood stasis. Heart failure (HF) is a complex cardiovascular disease, always leading to frequent onset and hospitalization, decreased quality of life, increased mortality, etc. Many clinical studies demonstrate that DSI has a good treatment on HF. We will provide a protocol to evaluate the effectiveness and safety of DSI for HF.

Methods:
We will systematically search 3 English databases (PubMed, Excerpta Medica database [EMBASE], the Cochrane Central Register of Controlled Trials [Cochrane Library]) and 4 Chinese databases (Chinese National Knowledge Infrastructure [CNKI], Chinese VIP Information, Wanfang Database, and Chinese Biomedical Literature Database [CBM]) for randomised controlled trials (RCT) of DSI for HF. Left ventricular ejection fraction (LVEF), ejection fraction, left ventricular end diastolic dimension (LVEDD), and six-minute walk distance (SWD) will be set as the primary outcome measures. The secondary outcome measures will include NT-pro BNP, quality of life and adverse reaction. All data will be analysed by using Stata 14.0 software and TSA v0.9 software. We will use I
2 test statistics to assess the heterogeneity of included studies, and Begg's funnel plots and Egger's test to assess publication bias. Methodological quality will be assessed through a Cochrane risk of bias tool for randomized controlled trials (RCTs).

Result:
This study will provide a high quality evidence for DSI on HF.

Conclusion:
This protocol will provide a reliable evidence to evaluate the effectiveness and safety of DSI on HF.

Registration:
PROS-PERO CRD42019125274.
A diagnostic challenge of seromucinous borderline tumor
Authors: Liu Tingting , Sumida Daichi , Wada Takuya , Maehana Tomoka , Yamawaki Aika , Sugimoto Sumire , Kawahara Naoki , Yoshimoto Chiharu , Kobayashi Hiroshi 
Published: May 2019

Abstract

Introduction:
Magnetic resonance (MR) relaxometry provides a noninvasive predictive tool to discriminate between benign ovarian endometrioma (OE) and endometriosis-associated ovarian cancer (EAOC). Transverse relaxation rate R2 value was determined using a single-voxel, multi-echo MR sequence (HISTO) by a 3T-MR system. R2 with cutoff value of 12.1 s−1 was established to discriminate between benign and malignant tumors.

Patient concerns:
We present a case of a 39-year-old woman who was initially thought to be malignant transformation of endometriosis by diagnostic MR imaging of the vascularized solid components.

Diagnosis:
A R2 value of 42.62 s−1 on MR relaxometry demonstrated that this case is non-malignant.

Interventions:
To confirm the diagnose, left salpingo-oophorectomy by laparoscopic surgery was performed.

Outcomes:
Histopathological results revealed seromucinous borderline tumor (SMBT). Our experience suggests that preoperative MR relaxometry may be useful for discriminating “borderline (SMBT)” from “malignancy (EAOC).” Furthermore, immunohistochemical studies of this case demonstrated ovarian SMBT cells were positive for estrogen receptor, progesterone receptor, and hepatocyte nuclear factor-1beta. A similar expression pattern was also observed in patients with benign OE.

Lessons:
In many respects, SMBT characteristics differ from those of EAOC but resemble those of benign OE. MR relaxometry unveils a new clinical approach as an adjunctive modality for discriminating SMBT from EAOC.
Persistent cholestasis resulting from duodenal papillary carcinoma in an adolescent male
Authors: Fu Haiyan , Li Yingchao , Bai Gelan , Yin Runkai , Yin Chunlan , Shi Weina , Zhang Lili , Li Rongpin , Zhao Ruiqin 
Published: May 2019

Abstract

Rationale:
Cholestasis in pediatric patients has diverse etiologies and can be broadly classified as intrahepatic or extrahepatic. The common causes of extrahepatic cholestasis are bile duct calculus, inflammation, or pancreatitis. Malignant tumor is a rare cause of bile ducts obstruction in adolescent. Here we report a 14-year-old male patient with cholestasis due to poorly differentiated adenocarcinoma.

Patient concerns:
A 14-year-old male patient with cholestasis was admitted because of jaundice, weakness, weight loss, and stomach pain for 2 months. The patient had been diagnosed with epilepsy 4 years previously and was being treated with sodium valproate and oxcarbazepine. On admission, laboratory studies showed elevated levels of aspartate aminotransferase (271 IU/L), alanine aminotransferase (224 IU/l), γ-glutamyltransferase (1668.9 IU/L), total bilirubin (66.4 μmol/L), and direct bilirubin (52.6 μmol/L). Additional laboratory tests eliminated common causes of cholestasis such as bacterial/viral infection, autoimmune liver disease, Wilson disease, Alagille syndrome, or progressive familial intrahepatic cholestasis type 3. The results of laboratory investigations showed no improvement after 10 days of treatment with ursodeoxycholic acid and vitamins A, D, and K1. Enhanced magnetic resonance imaging demonstrated a tumor of 22 mm diameter in the duodenal lumen and dilatation of the common bile duct. Endoscopic retrograde cholangiopancreatography detected a tumor in the duodenal lumen.

Diagnosis:
Considering the clinical features, imaging manifestation, endoscopic findings, and pathologic characteristic, the patient was diagnosed with poorly differentiated adenocarcinoma.

Interventions:
The patient underwent pancreaticoduodenectomy and chemotherapy.

Outcome:
The patient recovered well. Elevated levels of tumor biomarkers or abnormal liver function tests have not occurred during the 2-year follow-up.

Conclusion:
Cholestasis resulting from primary duodenal papillary carcinoma is rare in pediatric patients but should be considered in the differential diagnosis.
Prevalence of back pain and the knowledge of preventive measures in a cohort of 11619 Polish school-age children and youth—an epidemiological study
Authors: Kędra Agnieszka , Kolwicz-Gańko Aleksandra , Sitarski Dominik , Kędra Przemysław , Czaprowski Dariusz 
Published: May 2019

Abstract
The study sought to characterize back pain (BP) (in the period of 12 months) in children and youth aged 10 to 19 from eastern Poland.
The study included 11619 children and youth (6254 girls and 5365 boys) aged 10 to 19 from eastern Poland. An original questionnaire was applied as a research tool. Before the study, the reliability of the questionnaire had been assessed. The Kappa coefficient value for all the analyzed variables was equal to or higher than 0.91.
Over 74.4% of the respondents admitted that within the last 12 months, they had experienced BP which was usually located in the lumbar spine (55.8%). The percentage of individuals reporting BP increased with age of participants. Girls reported BP more often than boys (82.8% vs 64.3%). The main circumstances in which BP occurred included lifting heavy objects, carrying school backpack and maintaining a sedentary position (70.7% vs 67.4% vs 67.8%). Over 67% of the respondents declared they did not know ergonomic principles.
High prevalence of BP was noted. The declared BP was mainly located in the lumbar spine. Girls reported BP more often than boys. The students presented a very low level of knowledge about ergonomics. Therefore, the appropriate education should be included at school.