bluuebunny/crossref_metadata_2025_split huggingface dataset:
Processing and Properties of High-Entropy Ultra-High Temperature Carbides
Authors: Castle Elinor , Csanádi Tamás , Grasso Salvatore , Dusza Ján , Reece Michael 
Published: May 2018

AbstractBulk equiatomic (Hf-Ta-Zr-Ti)C and (Hf-Ta-Zr-Nb)C high entropy Ultra-High Temperature Ceramic (UHTC) carbide compositions were fabricated by ball milling and Spark Plasma Sintering (SPS). It was found that the lattice parameter mismatch of the component monocarbides is a key factor for predicting single phase solid solution formation. The processing route was further optimised for the (Hf-Ta-Zr-Nb)C composition to produce a high purity, single phase, homogeneous, bulk high entropy material (99% density); revealing a vast new compositional space for the exploration of new UHTCs. One sample was observed to chemically decompose; indicating the presence of a miscibility gap. While this suggests the system is not thermodynamically stable to room temperature, it does reveal further potential for the development of new in situ formed UHTC nanocomposites. The optimised material was subjected to nanoindentation testing and directly compared to the constituent mono/binary carbides, revealing a significantly enhanced hardness (36.1 ± 1.6 GPa,) compared to the hardest monocarbide (HfC, 31.5 ± 1.3 GPa) and the binary (Hf-Ta)C (32.9 ± 1.8 GPa).
Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein
Authors: Martin Esther M. , Kondrat Frances D. L. , Stewart Alan J. , Scrivens James H. , Sadler Peter J. , Blindauer Claudia A. 
Published: May 2018

AbstractZinc modulates the biological function of histidine-rich glycoprotein (HRG) through binding to its His-rich region (HRR). The Zn2+-binding properties of a 35 amino-acid biologically-active peptide mimic of the HRR, HRGP330, were investigated using dissociative mass spectrometry approaches in addition to travelling-wave ion mobility mass spectrometry (TWIM-MS). Native mass spectrometry confirmed zinc binding to HRGP330; however, broadening of the 1H NMR resonances upon addition of Zn2+ ions precluded the attainment of structural information. A complementary approach employing TWIM-MS indicated that HRGP330 has a more compact structure in the presence of Zn2+ ions. Top-down MS/MS data supported a metal-binding-induced conformational change, as fewer fragments were observed for Zn2+-bound HRGP330. Zn2+-bound fragments of both N-terminal and C-terminal ends of the peptide were identified from collision-induced dissociation (CID) and electron transfer dissociation/proton transfer reaction (ETD/PTR) experiments, suggesting that multiple binding sites exist within this region of HRG. The combination of mass spectrometry and NMR approaches provides new insight into the highly dynamic interaction between zinc and this His-rich peptide.
Phototoxic effects of two common marine fuels on the settlement success of the coral Acropora tenuis
Authors: Nordborg F. Mikaela , Flores Florita , Brinkman Diane L. , Agustí Susana , Negri Andrew P. 
Published: May 2018

AbstractCoral reefs are at risk of exposure to petroleum hydrocarbons from shipping spills and uncontrolled discharges during extraction. The toxicity of petroleum hydrocarbons can substantially increase in the presence of ultraviolet radiation (UVR), therefore spills in shallow coral reef environments may be particularly hazardous to reef species. Here we investigated the sensitivity of coral larvae (Acropora tenuis) to dissolved hydrocarbons from heavy fuel oil (HFO) and diesel in the absence and presence of UVR. Larval settlement success decreased with increasing concentrations of dissolved HFO, and co-exposure to UVR doubled the toxicity: 50% effect concentrations (EC50) decreased from 96 (−UVR) to 51 (+UVR) total petroleum aromatic hydrocarbons (TPAH). Toxic thresholds for HFO were similar to concentrations reported during marine spills: EC10s of 24 (−UVR) and 15 (+UVR) µg l−1. While less toxic, diesel also reduced settlement and exhibited phototoxicity: EC10s of 122 (+UVR) and 302 (−UVR) µg l−1. This study demonstrates that the presence of UVR increases the hazard posed by oil pollution to tropical, shallow-water coral reefs. Further research on the effects of oils in the presence of UVR is needed to improve the environmental relevance of risk assessments and ensure appropriate protection for shallow reef environments against oil pollution.
MHD Flow of Sodium Alginate-Based Casson Type Nanofluid Passing Through A Porous Medium With Newtonian Heating
Authors: Khan Arshad , Khan Dolat , Khan Ilyas , Ali Farhad , Karim Faizan ul , Imran Muhammad 
Published: May 2018

AbstractCasson nanofluid, unsteady flow over an isothermal vertical plate with Newtonian heating (NH) is investigated. Sodium alginate (base fluid)is taken as counter example of Casson fluid. MHD and porosity effects are considered. Effects of thermal radiation along with heat generation are examined. Sodium alginate with Silver, Titanium oxide, Copper and Aluminum oxide are added as nano particles. Initial value problem with physical boundary condition is solved by using Laplace transform method. Exact results are obtained for temperature and velocity fields. Skin-friction and Nusselt number are calculated. The obtained results are analyzed graphically for emerging flow parameters and discussed. It is bring into being that temperature and velocity profile are decreasing with increasing nano particles volume fraction.
Älterwerden im Beruf – Darstellung einer Gruppenintervention bei mittelalten Pflegekräften
Authors: Maatouk Imad , Helaß Madeleine 
Published: May 2018

ZusammenfassungDer Pflegeberuf unterliegt durch den demografischen Wandel starken Veränderungen, sowohl in der Alterszusammensetzung von Belegschaften, als auch in der Zunahme von multimorbiden, älteren Patienten. Die Prävalenz psychischer Belastung ist bei den Mitarbeitern im Gesundheitswesen bereits heute relativ hoch. Im Zuge der Veränderungen kommt es zu vermehrter psychischer und körperlicher Belastung. Es besteht ein Zusammenhang zwischen zunehmender Belastung und Gedanken an das Ausscheiden aus dem Beruf (intention to leave). Ziel der hier vorgestellten Gruppenintervention war es, eine verhaltenspräventive Maßnahme zur Förderung des gesunden Alterns im Pflegeberuf zur Verfügung zu stellen.
Analysis of Minimally Invasive Left Thoracotomy HVAD Implantation – A Single-Center Experience
Authors: Reichart D. , Brand C.F. , Bernhardt A.M. , Schmidt S. , Schaefer A. , Blankenberg S. , Reichenspurner H. , Wagner F.M. , Deuse T. , Barten M.J. 
Published: May 2018

Background Minimally invasive left ventricular assist device (LVAD) implantation may reduce peri-/postoperative complications and risks associated with resternotomies. In this study, we describe our first results using a minimally invasive LVAD implantation technique (lateral thoracotomy [LT] group). These results were compared with LVAD implantations done via full median sternotomy (STX group).
Methods HVAD (HeartWare, Framingham, Massachusetts, United States) implantations in 70 patients (LT group n = 22, 52 ± 15 years old; STX group n = 48, 59 ± 11 years old) were retrospectively analyzed. Minimally invasive access via left thoracotomy was feasible in 22 patients. Peri- and postoperative analyses of survival and adverse events were performed.
Results No survival differences were observed between the LT and STX group (p = 0.43). LT patients without temporary right ventricular assist device (tRVAD) showed a significantly better survival rate compared to LT patients with concomitant tRVAD implantation (p = 0.02), which could not be demonstrated in the STX group (p = 0.11). Two LT and four STX patients were successfully bridged to heart transplantation and three STX patients were successfully weaned with subsequent LVAD explantations. LVAD-related infections (n = 4 LT group vs n = 20 STX group, p = 0.04) were less likely in the LT group. No wound dehiscence occurred in the LT group, whereas five were observed in the STX group (p = 0.17). The amount of perioperative blood transfusions (within the first 7 postoperative days) did not differ in both study groups (p = 0.48).
Conclusion The minimally invasive approach is a viable alternative with the possibility to reduce complications and should be particularly considered for bridge-to-transplant patients.
Neuroprotective Strategies in Repair and Replacement of the Aortic Arch
Authors: Mullan Clancy , Catalano Michael , Manetta Frank 
Published: May 2018

AbstractAortic arch surgery is a technical challenge, and cerebral protection during distal anastomosis is a continued topic of controversy and discussion. The physiologic effects of hypothermic arrest and adjunctive cerebral perfusion have yet to be fully defined, and the optimal strategies are still undetermined. This review highlights the historical context, physiological rationale, and clinical efficacy of various neuroprotective strategies during arch operations.
Who Will Pay for Increasing Biofuel Mandates? Incidence of the Renewable Fuel Standard Given a Binding Blend Wall
Authors: Korting Christina , de Gorter Harry , Just David R. 
Published: May 2018

AbstractWe show that the cost of increasing biofuel mandates given a binding ethanol blend wall falls disproportionately on diesel fuel consumers. The extent of the burden on diesel fuel consumers is explained neither by their relatively more inelastic demand nor by blenders seeking to capitalize on the biodiesel tax credit. Relaxing the blend wall constraint by increasing the potential demand for high‐ethanol blends is the only effective lever to insulate diesel fuel drivers from the one‐sided welfare impacts of rising mandate levels. The independent effects of the nested mandate structure and the joint compliance base under the Renewable Fuel Standard (RFS) generate the link between motor gasoline and diesel fuel markets. Our results highlight the importance of evaluating the incidence of the RFS in a holistic framework taking both ethanol and biodiesel into account.
PERFect: PERmutation Filtering test for microbiome data
Authors: Smirnova Ekaterina , Huzurbazar Snehalata , Jafari Farhad 
Published: May 2018

Summary
The human microbiota composition is associated with a number of diseases including obesity, inflammatory bowel disease, and bacterial vaginosis. Thus, microbiome research has the potential to reshape clinical and therapeutic approaches. However, raw microbiome count data require careful pre-processing steps that take into account both the sparsity of counts and the large number of taxa that are being measured. Filtering is defined as removing taxa that are present in a small number of samples and have small counts in the samples where they are observed. Despite progress in the number and quality of filtering approaches, there is no consensus on filtering standards and quality assessment. This can adversely affect downstream analyses and reproducibility of results across platforms and software. We introduce PERFect, a novel permutation filtering approach designed to address two unsolved problems in microbiome data processing: (i) define and quantify loss due to filtering by implementing thresholds and (ii) introduce and evaluate a permutation test for filtering loss to provide a measure of excessive filtering. Methods are assessed on three “mock experiment” data sets, where the true taxa compositions are known, and are applied to two publicly available real microbiome data sets. The method correctly removes contaminant taxa in “mock” data sets, quantifies and visualizes the corresponding filtering loss, providing a uniform data-driven filtering criteria for real microbiome data sets. In real data analyses PERFect tends to remove more taxa than existing approaches; this likely happens because the method is based on an explicit loss function, uses statistically principled testing, and takes into account correlation between taxa. The PERFect software is freely available at https://github.com/katiasmirn/PERFect.
Oxygen-dependent regulation of immune checkpoint mechanisms
Authors: Ohta Akio 
Published: May 2018

Abstract
Immunotherapy of cancer has finally materialized following the success of immune checkpoint blockade. Since down-regulation of immune checkpoint mechanisms is beneficial in cancer treatment, it is important to ask why tumors are infamously filled with the immunosuppressive mechanisms. Indeed, immune checkpoints are physiological negative feedback mechanisms of immune activities, and the induction of such mechanisms is important in preventing excessive destruction of inflamed normal tissues. A condition commonly found in tumors and inflamed tissues is tissue hypoxia. Oxygen deprivation under hypoxic conditions by itself is immunosuppressive because proper oxygen supply could support bioenergetic demands of immune cells for optimal immune responses. However, importantly, hypoxia has been found to up-regulate a variety of immune checkpoints and to be able to drive a shift toward a more immunosuppressive environment. Moreover, extracellular adenosine, which accumulates due to tissue hypoxia, also contributes to the up-regulation of other immune checkpoints. Taken together, tissue oxygen is a key regulator of the immune response by directly affecting the energy status of immune effectors and by regulating the intensity of immunoregulatory activity in the environment. The regulators of various immune checkpoint mechanisms may represent the next focus to modulate the intensity of immune responses and to improve cancer immunotherapy.
The Impact of Different Postgraduate Year Training in Neurosurgery Residency on 30-Day Postoperative Outcomes
Authors: Macki Mohamed , Fakih Mohamed , Rubinfeld Ilan , Chang Victor , Walters Beverly C 
Published: May 2018

Abstract

BACKGROUND
Previous studies have failed to demonstrate statistically significant differences in postsurgical outcomes between operative cases featuring resident participation compared to attending only; however, the effects of level of postgraduate year (PGY) training have not been explored.

OBJECTIVE
To correlate different PGYs in neurosurgery with 30-d postoperative outcomes.

METHODS
Using National Surgical Quality Improvement Program 2005–2014, adult neurosurgical cases were divided into subspecialties: spine, open-vascular, cranial, and functional in teaching institutions. Comparison groups: cases involving junior residents (PGY 1–PGY 3), mid-level residents (PGY 4 + PGY 5), and senior residents (PGY 6 + PGY 7). Primary outcome measures included any wound disruption (surgical site infections and/or wound dehiscence), Clavien-Dindo grade IV (life-threatening) complications, and death.

RESULTS
Compared to junior residents (n = 3729) and mid-level residents (n = 2779), senior residents (n = 3692) operated on patients with a greater comorbidity burden, as reflected by higher American Society of Anesthesiology classifications and decreased level of functional status. Cases with senior resident participation experienced the highest percentages of postoperative wound complications (P = .005), Clavien-Dindo grade IV complications (P = .001), and death (P = .035). However, following multivariable regression, level of residency training in neurosurgery did not predict any of the 3 primary outcome measures. Compared to spinal cases, cranial cases predicted a higher incidence of life-threatening complications (odds ratio 1.84, P < .001).

CONCLUSION
Cases in the senior resident cohort were more technically challenging and exhibited a higher comorbidity burden preoperatively; however, level of neurosurgical training did not predict any wound disruption, life-threatening complications, or death. Residents still provide safe and effective assistance to attending neurosurgeons.
Endonasal Suturing of Nasoseptal Flap to Nasopharyngeal Fascia Using the V-Loc™ Wound Closure Device: 2-Dimensional Operative Video
Authors: Zwagerman Nathan T , Geltzeiler Mathew N , Wang Eric W , Fernandez-Miranda Juan C , Snyderman Carl H , Gardner Paul A 
Published: May 2018

Abstract
We present a case of cerebrospinal fluid (CSF) leak after endoscopic endonasal resection of a large clival chordoma in an obese patient. The leak was at the lower reconstruction at the craniocervical junction and had failed repositioning. Using the V-Loc™ wound closure device (Covidien, New Haven, Connecticut) to suture the nasoseptal flap to the nasopharyngeal fascia, a water-tight seal was created and, along with a lumbar drain, the patient healed successfully.
CSF leak after an endoscopic endonasal approach (EEA) to intradural pathologies remains one of the more common complications.
1-4
Various closure techniques have been developed
5-8
with success in mitigating this risk, but all have their limitations and rely on multiple layers including vascularized flaps like the nasoseptal flap.
9-11
Endonasal suturing of graft materials offers the advantage of creating a water-tight seal. We present the use of the V-Loc™ wound closure device (Covidien) to successfully seal a postoperative CSF leak. The absorbable V-Loc™ wound closure device does not require the surgeon to tie knots, which is the most challenging step in a deep, 2-dimensional corridor. The suture is barbed and is anchored by threading the needle through a prefabricated loop at the end of the suture which locks in place. Each throw of the suture through tissue maintains the suture line as the barbs catch the tissue and prevent retraction. After successful closure, the needle can simply be cut off.
The V-Loc™ wound closure device (Covidien) is a safe and effective adjunct to reconstruction after endoscopic endonasal skull base surgery as it provides an option for graft/flap suturing.
A written release from the patient whose name or likeness is submitted as part of this Work is on file.
Reasons for Opioid Discontinuation and Unintended Consequences Following Opioid Discontinuation Within the TOPCARE Trial
Authors: Husain Jawad M , LaRochelle Marc , Keosaian Julia , Xuan Ziming , Lasser Karen E , Liebschutz Jane M 
Published: May 2018

Abstract

Objective
To identify reasons for opioid discontinuation and post-discontinuation outcomes among patients in the Transforming Opioid Prescribing in Primary Care (TOPCARE) study.

Design
In TOPCARE, an intervention to improve adherence to opioid prescribing guidelines, randomized intervention primary care providers (PCPs) received nurse care manager support, an electronic registry, academic detailing, and electronic tools, and control PCPs received electronic tools only.

Setting
Four Boston safety net primary care practices.

Subjects
Patients in both TOPCARE study arms who discontinued opioid therapy during the trial.

Methods
Through chart review, we examined the reason for discontinuation and post-discontinuation outcomes: one or more PCP visits, one or more pain-related emergency department (ED) visits, evidence of opioid use disorder (OUD), and referral for OUD treatment.

Results
Opioid discontinuations occurred in 83/586 (14.2%) intervention and 42/399 (10.5%) control patients (P = 0.09). Among patients who discontinued opioids, 81 (65%) discontinued for misuse, with no difference by group (P = 0.38). Aberrancy in monitoring (e.g., discordant urine drug test results) was the most common type of misuse prompting discontinuation (occurring in (51/83 [61%] of intervention patients vs 19/42 [45%, P = 0.08] of control patients). Intervention patients who discontinued opioids had less PCP follow-up (65% vs 88%, P < 0.01) compared with control patients. We found no differences between groups for pain-related ED visits, evidence of OUD, or OUD treatment referral following discontinuation.

Conclusions
The decreased follow-up among TOPCARE intervention patients who discontinued opioids highlights the need to understand unintended consequences of involuntary opioid discontinuations resulting from interventions to reduce opioid risk.
Household Production in an Egalitarian Society
Authors: Onozaka Yuko , Hafzi Kamran 
Published: May 2018

Abstract
Norwegian national policies strongly incentivize double-earner households and gender equality, but various gender gaps persist both at work and at home. In these seemingly contradictory situations, what are the mechanisms under which Norwegian households allocate their market and domestic labor? Drawing on both a large set of administrative data and a representative survey, this question is examined from two perspectives. First, we focus on the micro-economic processes and investigate if Norwegian households act according to economic rationality or if they still follow the gender norm “A man should earn more than his wife.” Second, we focus on how Norway’s contextual factors may influence the household experiences when a wife has better market productivity. We find that a wife with better market productivity, who is thereby facing the risk of outearning her husband, works more hours and earns more than her husband, while doing less chores—behavior consistent with economic rationality. Further analyses show that women’s “higher” relative market productivity is mainly a consequence of having low-income husbands, and “higher” and “lower” market productivity women are surprisingly similar in other sociodemographic aspects. Norwegian redistribution policies, through progressive taxation and benefit transfers, seem to mitigate the income differences and promote gender neutrality in a sense that if couples wish to pursue an untraditional division, by preference or by necessity, they seem to be able to do so without being held back by the traditional gender expectations or being very poor.
Therapeutic progestin segesterone acetate promotes neurogenesis: implications for sustaining regeneration in female brain
Authors: Chen Shuhua , Kumar Narender , Mao Zisu , Sitruk-Ware Regine , Brinton Roberta Diaz 
Published: May 2018

AbstractObjective:Neurogenesis is the principal regenerative mechanism to sustain the plasticity potential in adult brains. Decreased neurogenesis parallels the cognition decline with aging, and has been suggested as a common hallmark in the progression of many neurodegeneration diseases. We previously reported that acute exposure to segesterone acetate (ST-1435; Nestorone), alone or in combination with 17β-estradiol (E2), increased human neural stem cells proliferation and survival both in vitro and in vivo. The present study expanded our previous findings to investigate the more clinical related chronic exposure in combination with E2on the regenerative capacity of adult brain.Methods:To mimic the chronic contraception exposure in women, 3-month old female mice (n = 110) were treated with ST-1435, with or without co-administration of E2, for 4 weeks. Neural cell proliferation and survival, and oligodendrocyte generation were assessed. The involvement of insulin-like growth factor 1 signaling was studied.Results:Our results demonstrated that chronic ST-1435 and E2alone or in combination increased neurogenesis by a comparable magnitude, with minimum to no antagonistic or additive effects between ST-1435 and E2. In addition, chronic exposure of ST-1435 or ST-1435 + E2stimulated oligodendrocyte generation, indicating potential elevated myelination. Insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) were also up-regulated after chronic ST-1435 and E2exposure, suggesting the involvement of IGF-1 signaling as the potential underlined regulatory pathway transducing ST-1435 effect.Conclusion:These findings provide preclinical evidence and mechanistic insights for the development of ST-1435 as a neuroregenerative therapy to promote intrinsic regenerative capacity in female brains against aging and neurodegenerative disorders.