bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen
Authors: Lai Alvina G. , Forde Donall , Chang Wai Hoong , Yuan Fang , Zhuang Xiaodong , Orbegozo Rubio Claudia , Song Chun-Xiao , McKeating Jane A. 
Published: September 2018

Background: Little is known about the impact of nutrients on cellular transcriptional responses, especially in face of environmental stressors such as oxygen deprivation. Hypoxia-inducible factors (HIF) coordinate the expression of genes essential for adaptation to oxygen-deprived environments. A second family of oxygen-sensing genes known as the alpha-ketoglutarate-dependent dioxygenases are also implicated in oxygen homeostasis and epigenetic regulation. The relationship between nutritional status and cellular response to hypoxia is understudied. In vitro cell culture systems frequently propagate cells in media that contains excess nutrients, and this may directly influence transcriptional response in hypoxia. Methods: We studied the effect of glucose and glutamine concentration on HepG2 hepatoma transcriptional response to low oxygen and expression of hypoxia inducible factor-1α (HIF-1α). Mass spectrometry confirmed low oxygen perturbation of dioxygenase transcripts resulted in changes in DNA methylation. Results: Under normoxic conditions, we observed a significant upregulation of both HIF-target genes and oxygen-dependent dioxygenases in HepG2 cells cultured with physiological levels of glucose or glutamine relative to regular DMEM media, demonstrating that excess glutamine/glucose can mask changes in gene expression. Under hypoxic conditions, CA9 was the most upregulated gene in physiological glutamine media while TETs and FTO dioxygenases were downregulated in physiological glucose. Hypoxic regulation of these transcripts did not associate with changes in HIF-1α protein expression. Downregulation of TETs suggests a potential for epigenetic modulation. Mass-spectrometry quantification of modified DNA bases confirmed our transcript data. Hypoxia resulted in decreased DNA hydroxymethylation, which correlated with TETs downregulation. Additionally, we observed that TET2 expression was significantly downregulated in patients with hepatocellular carcinoma, suggesting that tumour hypoxia may deregulate TET2 expression resulting in global changes in DNA hydroxymethylation. Conclusion: Given the dramatic effects of nutrient availability on gene expression, future in vitro experiments should be aware of how excess levels of glutamine and glucose may perturb transcriptional responses.
Discusión
Authors: Zukerfeld Nicolás , Peleteiro Bárbara , Contardi Marilyn , Novak Juan , Moreno Rodrigo , Solarz Malena 
Published: September 2018

Los libros de cine: El cine según Hitchcock, de Truffaut
El libro Santa Fe ciudad Set, las revistas Revista de cine y Cuadernos de cine documental
Redes Sociais Corporativas: Avaliação da Centralidade de Grau Através de Índices Como Ferramenta de Gestão.
Authors: Gulini Aldérico Silvio , Misaghi Mehran 
Published: September 2018

As redes sociais online estão se tornando cada vez mais populares, já tomam conta de boa parte dos conteúdos da Web, suas aplicações encontram-se presentes em nossa rotina através do compartilhamento de informações e engajamento de grupos com afinidades comuns. Esta nova forma de comunicação vem chamando a atenção de muitas organizações, onde se percebe um grande movimento organizacional fazendo com que muitas empresas iniciem uma busca por aplicações que forneçam possibilidades de interação entre funcionários, clientes e até mesmo fornecedores no ambiente corporativo. A proposta deste artigo é levantar uma breve discussão sobre a utilização das redes sociais nas organizações, identificar as dificuldades quanto a manipulação e gerenciamento de um grande volume de informações. Demonstrar a importância da análise estatística através de suas propriedades como ferramenta para auxiliar a correta tomada de decisão fazendo uso e comparações sob o aspecto de três índices de avaliação.
Blood profile and gut microbial load of broilers fed siam weed (Chromolaena odorata) leaf meal in their diets
Authors: Jiwuba Peter-Damian Chukwunomso , Ogbuewu Ifeanyi Princewill , Dauda Elisha , Azubuike Caritas Chibuike 
Published: September 2018

AbstractThe responses of 96 day old broilers fed Chromolaena odorata leaf meal (COLM) on blood profile and gut microbial load were studied for 49 days. The birds were randomly assigned to four treatment groups and replicated three times in a completely randomized design. The birds were fed four experimental diets formulated at 0%, 2%, 4% and 6% for the starter phase and 0%, 4%, 8% and 12% of COLM at the finisher phase for T1, T2, T3 and T4 respectively. All the haematological parameters were similar (P>0.05) across the treatment groups except MCH and WBC which were significantly (P< 0.05) higher and better in the treatment groups than the control group. The results on serum chemistry showed significant (P<0.05) difference for total protein, albumin, creatinine and cholesterol across the treatment groups. Cholesterol was significantly (P<0.05) reduced with increasing levels of COLM. Results showed that coliforms and E.coli were consistently higher (P<0.05) among the T1 birds than those fed T2, T3 and T4. It was concluded that, COLM enhanced adequate haematocrit and immune status, hypoglycaemic ability, suppresses the growth of gut pathogenic microorganisms and enhanced the growth of beneficial microorganism in broilers.
Yield performance and agronomic efficiency in oil pumpkins (Cucurbita pepo L. group Pepo) depending on production systems and varieties
Authors: Jakop Manfred , Grobelnik Mlakar Silva , Bavec Martina , Robačer Martina , Vukmanič Tjaša , Lisec Urška , Bavec Franci 
Published: September 2018

AbstractIn 2013 and 2014, a long-term trial (which was established in 2007) was conducted at the University Agricultural Centre in Pivola near Hoče. It included different production systems (conventional, integrated, organic, biodynamic), carried out in a field trial with oil pumpkins. The aim of the research was to analyse the effects of different production systems, varieties (hybrid and population variety) and years of production, on formation of oil pumpkin yields. The agricultural practice has been carried out in accordance with the applicable legislations and standards for the individual production system. When sowing, before fertilizing with nitrogen in early June and after the harvest, the amount of soil mineral nitrogen was monitored. We evaluated the number and weight of harvestable, unripe and decayed fruits, and yield of oil seed pumpkins and calculated the agronomic efficiency of the applied nutrients. The results showed that the year of production, the production system and the variety have a significant effect on some fruit characteristics and the yield of oil pumpkin seeds. The content of soil mineral nitrogen in May and September was significantly influenced by the production system and the year. In June, only the production system had a significant effect. The hybrid significantly increased the yields of oil pumpkin seeds in all production systems, even in the year that was less suitable for production. The agronomic efficiency of the applied nutrients in the biodynamic and organic production system is higher or equal than in the conventional production system, similarly, agronomic efficiency is higher in the hybrid compared to the oldest population variety efficiently. A comparable oil pumpkin yield can be expected in biodynamic and organic production, when proper nutrition and well carried out cultivation practices are combined with a new variety, when compared to less sustainable production systems, which often cause damage to the environment.
Geotourism and Mining Heritage: a Potential Gold Mine for Central Nigeria
Authors: Goki Nathaniel G. , Iyakwari Shekwonyadu , Umbugadi Allu A. 
Published: September 2018

Abstract
The potential for geotourism and mining heritage of some landscapes in parts of Kaduna, Plateau, Nasarawa and Kwara states in central Nigeria were studied and compiled. The result show that geological endowments range from insalbergs, flood basalts and dome structures, which presents natural landscape for tourism. The quartzite ridges of the Oreke area in Ilorin host the Owu Falls of 120m cascading waters, the Kafanchan flood basalts that flowed extensively from the Kagoro hills with extensive columnar jointing creating the prestigious water falls of over 30m all present versed potential for geotourism. Mining activity around the Jos Plateau (Bassa, Jos, Bukuru, Barakin Ladi and Bokkos areas), southern Kaduna (Godogodo and Jagindi) create landscapes that if properly beautified can become tourist landmarks. Adopting and harnessing these landscapes can boost and provide alternative revenue for the affected central.
The transverse arch collapse correction as a path to foot toes alignment
Authors: Dygut Jacek , Piwowar Piotr , Kogut Wojciech , Boroń Wiktor , Piwowar Monika 
Published: September 2018

Abstract
The study presents a fragment of pilot studies showing the reconstruction of the transverse arch of the foot using a specially constructed orthosis for this purpose. It involves the mechanical reinforcement of the effect by an orthosis, which pushes down the I, IV, and V metatarsal bones while elevating or blocking the fall of the near-immobile II and III metatarsal bones according to the “three-force” rule. The correction of the transverse arch of the foot runs simultaneously with the correction of hallux valgus (HV). As a result, the significant correction of HV and associated toe deformities was achieved. In stage I foot deformity, the reduction of HV was reduced from 19.1° before to 15.1° after putting on orthosis (p = 0.024). In stage II, the reduction was from 20.1° (before) to 16.2° (after; p = 0.032). Equally satisfactory results were obtained for the remaining angles of the metatarsal bones. In the future, the method can be suitable for patients undergoing preparation for corrective HV surgery and for maintaining postoperative HV results. It can be used preventively, for example, by women who frequently wear high-heeled shoes and by those who need to remain standing for prolonged periods of time.
Modeling Completion of Vocational Education: The Role of Cognitive and Noncognitive Skills by Program Type
Authors: Stratton Leslie S. , Datta Gupta Nabanita , Reimer David , Holm Anders 
Published: September 2018

Abstract
This study provides evidence of the importance of cognitive and noncognitive skills to completion of three types of vocational training (VET): education and health, technical, and business. Math and language exam scores constitute the key measures of cognitive skills; teacher-assigned grades the key measure of noncognitive skills. The data consist of two 9-year panels of youth completing compulsory education in Denmark. Estimation of completion proceeds separately by gender and VET type, controlling for selection and right censoring. The authors find that all skills are inversely related to VET enrollment, even controlling for family-specific effects. Estimates for completion vary considerably by program type, demonstrating the methodological importance of distinguishing among different VET courses. Math scores are positively related to certification for all VET tracks, though with very different magnitudes; language skills are inversely related for the nonbusiness tracks; and noncognitive skills appear important primarily for the business track.
Discretion rather than rules? Outdated optimal commitment plans versus discretionary policymaking
Authors: Jensen Christian 
Published: September 2018

Abstract
Because optimal plans are time-inconsistent, continuing one from a previous period is not optimal from today’s perspective, and may not outperform discretion, even ignoring surprise deviations. Hence, a once-and-for-all commitment to the optimal plan from a particular period does not always outperform discretion over time, even if superior from the perspective of the original period. Forward-looking policymakers might therefore not want to bind themselves to the optimal plan from any period. The vast literature on commitment strategies illustrates that it is a common misconception that a once-and-for-all commitment to the optimal plan is always preferable to discretion.
Corneal Perforation in a Patient with Chronic Keratouveitis and Gout: Case Report
Authors: Partojeva Rita , Elksnis Eriks , Laganovska Guna 
Published: September 2018

Abstract
The ophthalmic manifestations of gout are rare. There are only few published reports and study about it. The majority of patients with ocular gout abnormalities are asymptomatic. The authors discuss the case of a 43-year-old male who presented with central corneal keratolysis with perforation. The patient has an approximately 14-year history of gout attacks and chronic keratouveitis witch started about the same time. Coincidence of keratouveitis in a patient with gout has not been reported and it is unclear if this condition is rare or may only be by chance at the same time with gout.
Total Corneal Transplantation after Trauma
Authors: Silina Elina , Laganovska Guna 
Published: September 2018

Abstract
The first successful corneal transplantation is known since 1905, performed by Eduard Zirm (2). It has been implemented in order to restore vision in a variety of corneal diseases and after ocular traumas. The traditional technique for corneal transplantation, penetrating keratoplasty (PKP), refers to the full-thickness replacement of corneal tissue with a healthy donor graft (1). Authors report a well-documented case about successfully transplanted cornea after penetrating ocular trauma to improve visual outcome.
Passion and Creativity – Together or Separately?
Authors: Kunat Beata 
Published: September 2018

Abstract
In this paper I will attempt to compare two categories of passion and creativity. I will try to answer the question: What has passion got in common with creativity? What is the common denominator and what is different? What is the role of passion in the creative process? Searching for the mechanism of passion and its components is necessary to discover its relation to creativity I will refer to passion psychology (Vallerand, 2015). The basis of my analysis will be the Dualistic Model of Passion (Vallerand et al., 2003; Vallerand 2008, 2010, 2015), the concept of Grit: The Power of Passion and Perserverance (Duckworth et al., 2007; Duckworth & Quinn, 2009, Duckworth 2016) and the concept of Flow (Csíkszentmihályi, 1996). In the process of mapping the areas that connect passion with creativity I will refer to four ways of its understanding: creativity as a process, a personality trait complex, a product and the interaction between the creative individual and the context or environment. I will also refer in my comparisons to The four C Model of Creativity (Kaufman & Beghetto 2009).
The Four Ps of Creativity in the Drama/Theatre Project Jutka’s Sleeplessness
Authors: Witerska Kamila 
Published: September 2018

Abstract
The text is a case study report concerning research on a drama/theatre project called Jutka’s Sleeplessness that was performed in the public space of Łódź. The purpose of the research was to address the question of how this creative - new and valuable product - in the form of the drama/ theatre project Jutka’s Sleeplessness was created and what aspect of creativity decides on the success of a project that combines drama with theatre. The discussion represents an attempt to demonstrate how the four Ps of creativity work in a drama/theatre project.
Violence depicted in advertisements on LinkNYC kiosks in Manhattan, New York City
Authors: Basch Corey Hannah , LeBlanc Michael , Ethan Danna , Basch Charles E. 
Published: September 2018

Abstract
Violence has a profound negative impact on the lives of youth. Exposure to violence may be a precursor to violence later in life. The purpose of this study was two-fold: (1) to estimate the prevalence of violence depicted in advertisements on LinkNYC kiosks in Manhattan, NYC, and (2) to determine if violent advertising varied based on the median annual income of the zip code in which the kiosk was located. This cross-sectional study involved observations of advertisements on 100 LinkNYC kiosks that were selected randomly from 500 that were listed in Manhattan, NYC. The frequency and type of violent depictions were recorded. The kiosks were grouped into quartiles of median annual income (1) $40,782 and below (2) $40,783 to $86,801 (3) $86,802 to $105,500 and (4) $105,501 and above. Of the 2025 total advertisements observed, including duplicates, a total of 190 (9.4%) included violent content. These 190 advertisements were observed on 68 of the 100 kiosks and included 339 depictions of violence. The overwhelming majority (n = 136; 71.6%) of violent depictions were for movies. There were significant differences in the frequency of violent content based on income quartiles, χ2 (3, n = 190) = 19.00, p < 0.001. The highest two income quartiles had fewer violent advertisements than would be expected and the lowest quartile had more violent advertisements than expected. Symbols of violence were the most frequent type of violence portrayed observed in 85% of the violent advertisements observed (n = 161). Weapons, crime and fighting were observed in 5–11% of the advertisements. Our study suggests that greater alignment between the city’s aims to improve community health and reduce health disparities and advertising policies on LinkNYC warrants consideration.
Methanol to Gasoline Conversion over CuO/ZSM-5 Catalyst Synthesized Using Sonochemistry Method
Authors: Kianfar Ehsan , Salimi Mahmoud , Hajimirzaee Saeed , Koohestani Behnam 
Published: September 2018

AbstractIn this research, the catalytic conversion of methanol to gasoline range hydrocarbons has been studied over CuO (5 %)/ZSM-5 and CuO (7 %)/ZSM-5 catalysts prepared via sonochemistry methods. Conversion of methanol to gasoline (MTG) has been carried out in a fixed bed reactor under atmospheric pressure and 400˚C temperature, over copper oxide on the synthesized ZSM-5 catalyst. The samples were characterized by XRD, SEM, TEM, BET, and FTIR techniques; in which good crystallinity and high specific surface area of synthesized zeolite were proved after impregnation of zeolite with copper. The present investigation suggests that the CuO/ZSM-5 catalyst made by sonochemistry method can increase the yield toward hydrocarbon production. It was concluded that impregnation of zeolite with copper oxide can alter the Brønsted/Lewis acid sites ratio and provide new Lewis acid sites over the surface of the ZSM-5. The main products of methanol to gasoline reaction over the catalyst that prepared via sonochemistry method were toluene, xylene, ethylbenzene, ethyl toluene, tetra methylbenzene, diethyl benzene and butylbenzene. The total amount of aromatics in the products was 80 % by using this catalyst. Our results suggest that catalyst synthesized by using sonochemistry shows better production yield toward hydrocarbons by affecting the distribution of active sites on the surface of the ZSM-5.
Acoustic phonons in nanowires probed by ultrafast pump-probe spectroscopy
Authors: Mante Pierre-Adrien , Belliard Laurent , Perrin Bernard 
Published: September 2018

Abstract
The fascinating relationship between structure and property in nanowires has enabled a wealth of applications in photonics and electronics. The behavior of phonons in nanowires is also modified compared to their bulk counterparts. In this review, we provide an overview of the recent efforts to investigate the properties of acoustic phonons in nanowires using ultrafast optical methods. In particular, we focus on the calculation of the modified phonon dispersion in nanowires and how to address them optically. We then discuss experimental investigations in arrays of nanowires and a single nanowire. The analysis of phonon behavior reveals the possibility to perform advanced mechanical characterization and to vary the thermal properties of nanowires. The review concludes with a brief perspective on future research directions, from phonon-induced control over properties to three-dimensional (3D) acoustic nano-imaging.
Silent enhancement of SERS signal without increasing hot spot intensities
Authors: Postaci Selen , Yildiz Bilge Can , Bek Alpan , Tasgin Mehmet Emre 
Published: September 2018

Abstract
Plasmonic nanostructures enhance nonlinear response, such as surface enhanced Raman scattering (SERS), by localizing the incident field into hot spots. The localized hot spot field can be enhanced even further when linear Fano resonances take place in a double resonance scheme. However, hot spot enhancement is limited with the modification of the vibrational modes, the breakdown of the molecule, and the tunneling regime. Here, we present a method which can circumvent these limitations. Our analytical model and solutions of 3D Maxwell equations show that: enhancement due to the localized field can be multiplied by a factor of 102–103. Moreover, this can be performed without increasing the hot spot intensity which also avoids the modification of the Raman modes. Unlike linear Fano resonances, here, we create a path interference in the nonlinear response. We demonstrate on a single equation that enhancement takes place due to cancellation of the contributing terms in the denominator of the SERS response. Our method can be implemented on an atomic force microscope tip, decorated (or “contaminated”) with appropriate quantum emitters.
Lattice effect influence on the electric and magnetic dipole resonance overlap in a disk array
Authors: Babicheva Viktoriia E. , Moloney Jerome V. 
Published: September 2018

Abstract
Designing the shape of silicon nanoparticles has been shown to be an effective approach to increasing overlap between electric and magnetic dipole resonances thereby achieving directional scattering and decrease of reflection. Variations of disk diameter and/or height affect resonances differently and can thus result in resonance overlap. In most of the studies, the disks are arranged in a periodic array where the periodicity is varied together with disk diameter, but the role of lattice effect is neglected. Here we theoretically study a periodic array of disks and show that the contribution of the lattice effect in shifting resonance positions is comparable to the effect of the diameter change. We demonstrate that the lattice effect is important even when the wavelength of diffraction remains on the blue side from electric and magnetic dipole resonances and there are no additional lattice resonances excited. Period and disk dimensions are chosen so that the resonances overlap in the proximity of the telecommunication wavelength which is of great practical interest.
Following the Code: Spillovers and Knowledge Transfer
Authors: Gandal Neil , Naftaliev Peter , Stettner Uriel 
Published: September 2018

AbstractKnowledge spillovers in Open Source Software (OSS) can occur via two channels: In the first channel, programmers take knowledge and experience gained from one OSS project they work on and employ it in another OSS project they work on. In the second channel, programmers reuse software code by taking code from an OSS project and employing it in another. We develop a methodology to measure software reuse in a large OSS network at the micro level and show that projects that reuse code from other projects have higher success. We also demonstrate knowledge spillovers from projects connected via common programmers.