bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism Analysis and Experimental Study of Emulsified Wax Curing Agent as an Isolation Layer for Concrete Pavement
Authors: Yuan Jianbo , Yao Jialiang , Wang Huicong , Lin Yi 
Published: October 2018

Abstract
The functional mechanism of emulsified wax curing agent (EWCA) as an isolation layer of cement concrete pavement (CCP) was analyzed. Reducing the friction between layers and improving the hydrophobic function of concrete surface can weaken the combination of surface course and base course, as well as the formation of weak transition layer, which is generated during the construction of concrete undersurface course. After the cement concrete surface was sprayed with EWCA, its contact range was measured to be 97.3°∼101.1° in the contact angle test. With the nuclear magnetic resonance equipment, the study on the microstructure of the pavement slab of EWCA’s isolation layer was carried out. The isolation layer of EWCA can reduce the porosity of transition layer and enhance its compatibility. The effect of EWCA on the interlayer performance of concrete pavement was explored by the interlayer bonding and friction coefficient tests with different amounts of EWCA and different texture depths of base course. The Coulomb model of interlayer bonding and frictional resistance was established, which preliminarily indicated the functional mechanism of CCP’s emulsified isolation layer.
Unilateral, 3D Arm Movement Kinematics Are Encoded in Ipsilateral Human Cortex
Authors: Bundy David T. , Szrama Nicholas , Pahwa Mrinal , Leuthardt Eric C. 
Published: October 2018

There is increasing evidence that the hemisphere ipsilateral to a moving limb plays a role in planning and executing movements. However, the exact relationship between cortical activity and ipsilateral limb movements is uncertain. We sought to determine whether 3D arm movement kinematics (speed, velocity, and position) could be decoded from cortical signals recorded from the hemisphere ipsilateral to the moving limb. By having invasively monitored patients perform unilateral reaches with each arm, we also compared the encoding of contralateral and ipsilateral limb kinematics from a single cortical hemisphere. In four motor-intact human patients (three male, one female) implanted with electrocorticography electrodes for localization of their epileptic foci, we decoded 3D movement kinematics of both arms with accuracies above chance. Surprisingly, the spatial and spectral encoding of contralateral and ipsilateral limb kinematics was similar, enabling cross-prediction of kinematics between arms. These results clarify our understanding that the ipsilateral hemisphere robustly contributes to motor execution and supports that the information of complex movements is more bihemispherically represented in humans than has been previously understood.SIGNIFICANCE STATEMENTAlthough limb movements are traditionally understood to be driven by the cortical hemisphere contralateral to a moving limb, movement-related neural activity has also been found in the ipsilateral hemisphere. This study provides the first demonstration that 3D arm movement kinematics can be decoded from human electrocorticographic signals ipsilateral to the moving limb. Surprisingly, the spatial and spectral encoding of contralateral and ipsilateral limb kinematics was similar. The finding that specific kinematics are encoded in the ipsilateral hemisphere demonstrates that the ipsilateral hemisphere contributes to the execution of unilateral limb movements, improving our understanding of motor control. Additionally, the bihemisheric representation of voluntary movements has implications for the development of neuroprosthetic systems for reaching and for neurorehabilitation strategies following cortical injuries.
Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation
Authors: Omotade Omotola F. , Rui Yanfang , Lei Wenliang , Yu Kuai , Hartzell H. Criss , Fowler Velia M. , Zheng James Q. 
Published: October 2018

Neurons of the CNS elaborate highly branched dendritic arbors that host numerous dendritic spines, which serve as the postsynaptic platform for most excitatory synapses. The actin cytoskeleton plays an important role in dendrite development and spine formation, but the underlying mechanisms remain incompletely understood. Tropomodulins (Tmods) are a family of actin-binding proteins that cap the slow-growing (pointed) end of actin filaments, thereby regulating the stability, length, and architecture of complex actin networks in diverse cell types. Three members of the Tmod family, Tmod1, Tmod2, and Tmod3 are expressed in the vertebrate CNS, but their function in neuronal development is largely unknown. In this study, we present evidence that Tmod1 and Tmod2 exhibit distinct roles in regulating spine development and dendritic arborization, respectively. Using rat hippocampal tissues from both sexes, we find that Tmod1 and Tmod2 are expressed with distinct developmental profiles: Tmod2 is expressed early during hippocampal development, whereas Tmod1 expression coincides with synaptogenesis. We then show that knockdown of Tmod2, but not Tmod1, severely impairs dendritic branching. Both Tmod1 and Tmod2 are localized to a distinct subspine region where they regulate local F-actin stability. However, the knockdown of Tmod1, but not Tmod2, disrupts spine morphogenesis and impairs synapse formation. Collectively, these findings demonstrate that regulation of the actin cytoskeleton by different members of the Tmod family plays an important role in distinct aspects of dendrite and spine development.SIGNIFICANCE STATEMENTThe Tropomodulin family of molecules is best known for controlling the length and stability of actin myofilaments in skeletal muscles. While several Tropomodulin members are expressed in the brain, fundamental knowledge about their role in neuronal function is limited. In this study, we show the unique expression profile and subcellular distribution of Tmod1 and Tmod2 in hippocampal neurons. While both Tmod1 and Tmod2 regulate F-actin stability, we find that they exhibit isoform-specific roles in dendrite development and synapse formation: Tmod2 regulates dendritic arborization, whereas Tmod1 is required for spine development and synapse formation. These findings provide novel insight into the actin regulatory mechanisms underlying neuronal development, thereby shedding light on potential pathways disrupted in a number of neurological disorders.
A new p.(Ile66Serfs*93) IGF2 variant is associated with pre- and postnatal growth retardation
Authors: Rockstroh Denise , Pfäffle Heike , Le Duc Diana , Rößler Franziska , Schlensog-Schuster Franziska , Heiker John T , Kratzsch Jürgen , Kiess Wieland , Lemke Johannes R , Abou Jamra Rami , Pfäffle Roland 
Published: October 2018

Objective
The IGF/IGF1R axis is involved in the regulation of human growth. Both IGF1 and IGF2 can bind to the IGF1R in order to promote growth via the downstream PI3K/AKT pathway. Pathogenic mutations in IGF1 and IGF1R determine intrauterine growth restriction and affect postnatal body growth. However, to date, there are only few reports of pathogenic IGF2 mutations causing severe prenatal, as well as postnatal growth retardation.

Results
Here we describe a de novo c.195delC IGF2 variant (NM_000612, p.(Ile66Serfs*93)) in a 4-year-old patient with severe pre- and post-natal growth retardation in combination with dystrophy, facial dimorphism, finger deformities, as well as a patent ductus. Cloning and sequencing of a long-range PCR product harboring the deletion and a SNP informative site chr11:2153634 (rs680, NC_000011.9:g.2153634T>C) demonstrated that the variant resided on the paternal allele. This finding is consistent with the known maternal imprinting of IGF2. 3D protein structure prediction and overexpression studies demonstrated that the p.(Ile66Serfs*93) IGF2 gene variation resulted in an altered protein structure that impaired ligand/receptor binding and thus prevents IGF1R activation.

Conclusion
The severity of the phenotype in combination with the dominant mode of transmission provides further evidence for the involvement of IGF2 in growth disorders.
Genotype-by-Environment-by-Environment Interactions in the Saccharomyces cerevisiae Transcriptomic Response to Alcohols and Anaerobiosis
Authors: Sardi Maria , Krause Molly , Heilberger Justin , Gasch Audrey P 
Published: October 2018

Abstract
Next generation biofuels including longer-chain alcohols such as butanol are attractive as renewable, high-energy fuels. A barrier to microbial production of butanols is the increased toxicity compared to ethanol; however, the cellular targets and microbial defense mechanisms remain poorly understood, especially under anaerobic conditions used frequently in industry. Here we took a comparative approach to understand the response of Saccharomyces cerevisiae to 1-butanol, isobutanol, or ethanol, across three genetic backgrounds of varying tolerance in aerobic and anaerobic conditions. We find that strains have different growth properties and alcohol tolerances with and without oxygen availability, as well as unique and common responses to each of the three alcohols. Our results provide evidence for strain-by-alcohol-by-oxygen interactions that moderate how cells respond to alcohol stress.
PRP4KA, a Putative Spliceosomal Protein Kinase, Is Important for Alternative Splicing and Development in Arabidopsis thaliana
Authors: Kanno Tatsuo , Venhuizen Peter , Wen Tuan-Nan , Lin Wen-Dar , Chiou Phebe , Kalyna Maria , Matzke Antonius J M , Matzke Marjori 
Published: October 2018

Abstract
Prp4 kinase (Prp4k) is the first spliceosome-associated kinase shown to regulate splicing in fungi and metazoans, but nothing is yet known about its functions in plants. Here, Kanno and Venhuizen et al. report...
Splicing of precursor messenger RNAs (pre-mRNAs) is an essential step in the expression of most eukaryotic genes. Both constitutive splicing and alternative splicing, which produces multiple messenger RNA (mRNA) isoforms from a single primary transcript, are modulated by reversible protein phosphorylation. Although the plant splicing machinery is known to be a target for phosphorylation, the protein kinases involved remain to be fully defined. We report here the identification of pre-mRNA processing 4 (PRP4) KINASE A (PRP4KA) in a forward genetic screen based on an alternatively spliced GFP reporter gene in Arabidopsis thaliana (Arabidopsis). Prp4 kinase is the first spliceosome-associated kinase shown to regulate splicing in fungi and mammals but it has not yet been studied in plants. In the same screen we identified mutants defective in SAC3A, a putative mRNA export factor that is highly coexpressed with PRP4KA in Arabidopsis. Whereas the sac3a mutants appear normal, the prp4ka mutants display a pleiotropic phenotype featuring atypical rosettes, late flowering, tall final stature, reduced branching, and lowered seed set. Analysis of RNA-sequencing data from prp4ka and sac3a mutants identified widespread and partially overlapping perturbations in alternative splicing in the two mutants. Quantitative phosphoproteomic profiling of a prp4ka mutant detected phosphorylation changes in several serine/arginine-rich proteins, which regulate constitutive and alternative splicing, and other splicing-related factors. Tests of PRP4KB, the paralog of PRP4KA, indicated that the two genes are not functionally redundant. The results demonstrate the importance of PRP4KA for alternative splicing and plant phenotype, and suggest that PRP4KA may influence alternative splicing patterns by phosphorylating a subset of splicing regulators.
Blogųjų naujienų diskursas Lietuvos sovietmečio spaudoje
Authors: Gedzevičienė Dalia 
Published: October 2018

[abstract in English; full article and abstract in Lithuanian]
The rhetoric and the stylistics – the choice of text style, genre, and rhetorical devices – of Soviet bad news discourse is analysed in this paper. This discourse is represented by 193 reports regarding disasters, crimes, and violation of socialistic moral which were published in the daily paper Komjaunimo tiesa (eng. The Truth of the Komsomol) in 1970–1973. It was found that the bad news in the selection of official texts of this period distinguishes by a much lower register of Newspeak – unlike as in the articles of first pages, there is almost no pathos here, the militaristic metaphors are used in the text of the article only, but they cannot be seen in the headings. One of the main rhetorical devices is an irony, which is created by using phraseology, jargon, famous quotes, dialogues, etc., – everything, which looks like a daily colloquial language. The choice of text form which is more related to fiction than to journalism (essay, satire) may be treated as one of the pretexts which justify in the eyes of the readers an idea of an author to write in a different language than it was ordinary in the context of ideologized press language of that period. By using the corresponding rhetoric, they believed to accomplish the propagandistic aim of these texts more efficiently – to suggest an image of more safe, democratic, successful, and self-critical country than it really was.
The Translation of D. H. Lawrence’s Metaphors: the French Censored Passages in “The Rainbow” as a Case in Point
Authors: Louzir Aïcha 
Published: October 2018

[full article and abstract in English]
The aim of this study is to explore D. H. Lawrence’s style through the prism of his use of metaphor. As a particularly enlightening method, I shall compare some of the censored passages in “The Rainbow” (1915) against their French translations (1939, 2002). Focusing my attention on their stylistic particularities, I will examine the manner in which they were translated into French. The central argument of my paper is that Lawrence’s metaphors related to the body are a relevant tool highlighting the author’s vision of human relationships, within the context of prevalent views in the beginning of the 20th century. The British authorities banned “The Rainbow” since its first publication and accused Lawrence of pornography. Therefore, it is important to glance back in order to understand the reason behind the censorship and see that the translations of Lawrence’s oeuvre were decisive in spreading his ideas beyond the frontiers of his country of origin. My analysis mainly draws on a descriptive approach but it is at the crossroads of several paradigms, namely the interpretative approach in Translation Studies and the cognitive approach to the study of metaphors.
Kiekybinė parodomųjų įvardžių vartosena verstiniame ir neverstiniame tekste
Authors: Bartkutė Darija 
Published: October 2018

[full article and abstract in Lithuanian; abstract in English]
The article aims to estimate the distribution of demonstrative pronouns in the translated and nontranslated Lithuanian text as compared to the English original. The quantitative method and contrastive analysis based on the triangulation of data sources are used to reveal whether demonstrative pronouns show different distribution patterns in the English original and Lithuanian translation compared to the translated and non-translated Lithuanian text. The research material was collected from Harry Potter and the Goblet of Fire by J. K. Rowling and a fantasy novel Hour of the Wolf by A. Tapinas. The preferences identified did not indicate significant differences in the tendencies for the use of demonstrative pronouns in the translated and non-translated text of Lithuanian fiction but revealed significant cross-linguistic contrasts in the quantitative use of demonstratives. It was therefore presumed that there was no communicative difference between the translated and non-translated Lithuanian fictional text due to the genre and language conventions for the use of deictics and that the Lithuanian text demonstrated a preference for a more pronounced pragmatic explicitness than the English language text.
PENGARUH UKURAN MATA JARING BUBU LIPAT TERHADAP JUMLAH DAN UKURAN HASIL TANGKAPAN RAJUNGAN DI PERAIRAN UTARA LAMONGAN, JAWA TIMUR
Authors: Mahiswara Mahiswara , Hufiadi Hufiadi , Baihaqi Baihaqi , Budiarti Tri Wahyu 
Published: October 2018

Bubu lipat merupakan alat tangkap yang banyak dioperasikan nelayan untuk menangkap rajungan, namun memiliki selektivitas rendah tergantung pada ukuran mata jaring yang digunakan. Tingkat selektivitas bubu lipat perlu ditingkatkan agar tangkapan rajungan memiliki ukuran layak tangkap sesuai peraturan. Penelitian uji coba pengoperasian bubu lipat rajungan dengan berbagai ukuran mata jaring yaitu 1¼ , 2, 2½ dan 3 inci, berbentuk bujur sangkar telah dilakukan di perairan utara Lamongan, Jawa Timur. Jumlah bubu lipat yang dioperasikan untuk setiap ukuran mata jaring sebanyak 150 unit per tawur/setting. Tujuan penelitian, untuk mengetahui pengaruh ukuran mata jaring bubu terhadap jumlah dan ukuran hasil tangkapan rajungan. Hasil analisis menunjukkan bahwa perbedaan ukuran mata jaring berpengaruh nyata terhadap hasil tangkapan bubu lipat rajungan. Hasil tangkapan rajungan dari bubu lipat mata jaring 2 inci (2,17 kg/setting) tidak berbeda nyata dengan mata jaring 1¼ inci (2,08 kg/setting). Ukuran lebar karapas (CW=carapace width) rajungan layak tangkap (> 100 mm) semakin besar dengan meningkatnya ukuran mata jaring. Nilai tertinggi prosentase tangkapan rajungan ukuran besar (CW > 100 mm), ditemukan pada bubu lipat ukuran mata jaring 3 inci mencapai 98 % dari total rajungan yang tertangkap. Collapsible crab pot is a common fishing gear that has been operated by many fishermen, however this kind of fishing gear has a low selectivity. The selectivity level of crab pot needs to be increased so that the size of crab catch comply to the allowable legal size. Fishing trials of crab pot with the mesh size of 1¼, 2, 2½ and 3 inch square-shaped has been done in the waters of north Lamongan, East Java. The objectives of this research is to determine the effect of mesh size to the number and size of the catches. The results showed that different mesh size has significant effect on the catch of pot. However the catch of a 2 inch mesh size pot (of 2.17 kg / setting) was not significantly different with the catch of pot with 1¼ inch mesh size (of 2.08 kg / setting). Percentage of BSC catch with carapace width (CW) > 100 mm increased by increasing of mesh size of net. The highest percentage (98 % of the total catch) was obtained from the 3-inch mesh sizes.
ACCUMULATION OF METALS IN WHEAT CROP GROWN IN WASTEWATER CONTAMINATED SOIL IN PUNJAB, PAKISTAN

Running head:Heavy metals in wheat grown in contaminated soil
Authors: KHAN ZAFAR IQBAL , AHMAD Kafeel AHMAD , ASHFAQ ASMA  ASHFAQ , BATOOL FAUZIA , MAHMOOD Naunain , BASHIR HUMAYUN , MEMOONA HAFSA , NAWAZ KHALID , DIGAN YUNUS , UGULU ILKER 
Published: October 2018

aDepartment of Botany, University of Sargodha, Sargodha, Pakistan; zikhan11@gmail.com
KafeelAHMAD a,
aDepartment of Botany, University of Sargodha, Sargodha, Pakistan; kafeeluaf@yahoo.com
AsmaASHFAQ a,
aDepartment of Botany, University of Sargodha, Sargodha, Pakistan; aasmashfaq@gmail.com
FAUZIA BATOOL a,
aDepartment of Botany, University of Sargodha, Sargodha, Pakistan; f.batool99@yahoo.com
NaunainMAHMOOD b,
bDepartment of Zoology, University of Sargodha, Sargodha, Pakistan; naunainmahood@gmail.com 0000-0001-7852-9113
HUMAYUN BASHIR
aDepartment of Botany, University of Sargodha, Sargodha, Pakistan; humayunuos@gmail.com
HAFSA MEMOONA
bDepartment of Zoology, University of Sargodha, Sargodha, Pakistan;hafsamemooa@gmail.com
KHALID NAWAZ
bDepartment of Zoology, University of Gujrat, Pakistan;humayunuos1@gmail.com
YunusDOGAN c*,
cBuca Faculty of Education, DokuzEylul University, Izmir, Turkey;
*Corresponding author: yunus.dogan@deu.edu.tr 0000-0001-9404-6031

BSTRACT
The cheap way of disposal of wastewater is to use it in agriculture. The pressure in using fresh water resources may alleviate by the domestic wastewater in agriculture. Waste water holds significant quantity of plant nutrients like N, P, Ca, K, Co, Zn and Mn. Therefore, it increases the crop yield. Triticumaestivum is staple food crop for Pakistan where it is an important caloric source. It is grown successfully on rain fed areas of the country as well as in irrigated areas with minimum water without losing its production potential. In this study, cadmium (Cd), nickel (Ni), iron (Fe), manganese (Mn), copper (Cu), chromium (Cr), zinc (Zn), and cobalt (Co) were evaluated, effect of wastewater was studied on wheat variety (Punjab-2011) by applying different treatments of wastewater. Comparison between five different treatments, in soil, the Fe was highest. The chromium in current findings exceeded the permissible limit (0.03 mg/kg) in wheat grains. The reason of high Cr concentration might be due to the increased usage of wastewater for long period. The level of pollution or factor of contamination was lowest of Zn and was highest for Cd in all treatments. The chromium has lowest the value of health risk index while Cd has highest value in all treatments indicating that exposed population is unlikely to experience obvious adverse effects on utilization of these contaminated grains of wheat.
Keywords:wheat (Punjab-2011); heavy metals; wastewater; health risk;soil
Pengaruh Substitusi Puree Kulit Pisang Ambon (Musa x Paradisiaca L.) Pada Pembuatan Banana Cake Terhadap Daya Terima Konsumen
Authors: Muztniar Astri Mutia , Sachriani Sachriani , Cahyana Cucu 
Published: October 2018

The objective of this research was to analysis the effect of ambon banana peel puree substitution on making banana cake to consumer acceptance, include aspects of color, crumb color, aroma, taste and texture. The study was conducted at March to December 2016 . The study was conducted from March to December 2016 with experimental methods at the Laboratory of Pastry & Bakery and organolaptic assessment was conducted on Food and Nutrition Program at the State University of Jakarta.The results based on the hypothesis Friedman Test with significance level Î± = 0.05 showed there is not influence of ambon banana peel puree substitution on making banana cake to consumer acceptance in all aspect. Conclusion banana cake with three treatments could be accepted by consumers.
Penelitian ini bertujuan untuk menganalisis pengaruh substitusi puree kulit pisang ambon pada pembuatan banana cake terhadap daya terima konsumen, meliputi aspek warna kulit, warna remah, aroma, rasa dan tekstur. Penelitian dilakukan pada bulan Maret sampai Desember 2016 dengan metode eksperimen di Laboratorium Pastry & Bakery dan Penilaian Organolaptik dilakukan pada Mahasiswa Program Studi Tata Boga Universitas Negeri Jakarta. Hasil pengujian Hipotesis menggunakan uji friedman dengan taraf signifikansi Î± = 0,05 menunjukkan tidak terdapat pengaruh substitusi puree kulit pisang ambon pada pembuatan banana cake terhadap daya terima konsumen pada semua aspek. Kesimpulan banana cake dengan ketiga perlakuan dapat diterima oleh konsumen