bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bifunctional Mg−Cu‐Loaded β‐Zeolite: High Selectivity for the Conversion of Furfural into Monoaromatic Compounds
Authors: Karnjanakom Surachai , Yoshida Akihiro , Bayu Asep , Kurnia Irwan , Hao Xiaogang , Maneechakr Panya , Abudula Abuliti , Guan Guoqing 
Published: June 2018

AbstractMg−Cu‐loaded β‐zeolite was prepared as an acid−base bifunctional catalyst for the conversion of furfural to monoaromatic compounds. It is found that this catalyst exhibited high selectivity towards benzene, toluene and xylenes (BTXs) production with anti‐polycyclic‐aromatic‐hydrocarbon formation as well as anti‐coking ability when compared with Cu‐loaded β‐zeolite and the parent β‐zeolite. The product distribution indicated that addition of Cu species significantly promoted the deoxygenation and aromatization of an intermediate product of furan while Mg apparently suppressed the polyaromatization. Especially, an optimum loading amount of 0.5 wt%Mg‐1 wt%Cu on β‐zeolite was obtained, which showed lower catalytic deoxygenation temperature and interestingly, only benzene was detected in the liquid product at a reaction temperature over 700 °C. Also, 0.5 wt%Mg‐1 wt%Cu/β‐zeolite exhibited long‐term stability for 10 cycles with 100 % of furfural conversion to monoaromatic compounds. The physicochemical properties of β‐zeolite after Cu and Mg loadings were characterized using N2 sorption, XRD, SEM‐EDX, TEM, H2‐TPR, UV‐Vis, XPS, NH3‐TPD and CO2‐TPD techniques. The significant changing of acidity and basicity of β‐zeolite were found after Cu and Mg loadings, which should be the main factors for the improvement of activity, selectivity and stability of the developed catalyst.
Catalytic Process Optimization of Birnessite‐based Fenton‐like Reaction with Surface Cu2+ Modification
Authors: Zang Chengjie , Hu Shiyu , Jin Shihu , Chen Feng 
Published: June 2018

AbstractLayer‐structured birnessite (δ‐MnO2) has been applied recently in the heterogeneous Fenton‐like process. However, easy deactivation and low utilization efficiency of H2O2 limit its practical application. The catalytic processes of H2O2 on birnessite were successfully regulated via surface chemical modification as Cu2+ ions were intercalated into the birnessite by the ion‐exchange method (CuBir). The triple‐corner‐sharing inner‐sphere surface complexes of Cu2+ ions (TCS species) formed above Mn vacancies could effectively weaken the over‐complexation of H2O2 on the surface of [MnO6] sheets, and then decrease the self‐consumption of surface‐formed superoxide radicals. The surface TCS species have excellent Fenton‐like performances and enhance the conversion efficiency of H2O2 into reactive oxygen species (ROS). Moreover, the surface Cu2+‐modification engineering could prevent deactivation owing to degradation intermediate residues and improve the recyclability of catalyst.
Copper‐Basic Sites Synergic Effect on the Ethanol Dehydrogenation and Condensation Reactions
Authors: Quesada Jorge , Faba Laura , Díaz Eva , Ordóñez Salvador 
Published: June 2018

AbstractBioethanol upgrading through condensation is of key interest in the development of sustainable processes, shifting from fossil to renewable carbon. Here, a new strategy is proposed, which combines in one catalyst an appropriate distribution of acid/basic sites of a mixed oxide with the presence of an active dehydrogenation phase (Cu nanoparticles). Experiments, performed in a fixed bed reactor, reveal a very positive effect of Cu in the performance of Mg−Al catalyst, with 1‐butanol productivity 12 times higher at 523 K under inert conditions. The improvement is even more notable in presence of H2, almost 30 times higher, under same conditions. The presence of Cu on the surface increases the formation of acetaldehyde, limiting the extent of dehydration side‐reactions. In addition, hydrogen enhances the C4 hydrogenation, preventing oligomerizations and inhibiting decarbonylation steps that are directly related to the catalytic deactivation by poisoning.
Symptoms of posttraumatic stress disorder among hospitalized patients with cancer
Authors: Nipp Ryan D. , El‐Jawahri Areej , D'Arpino Sara M. , Chan Andy , Fuh Charn‐Xin , Johnson P. Connor , Lage Daniel E. , Wong Risa L. , Pirl William F. , Traeger Lara , Cashavelly Barbara J. , Jackson Vicki A. , Ryan David P. , Hochberg Ephraim P. , Temel Jennifer S. , Greer Joseph A. 
Published: June 2018

BACKGROUNDPatients with cancer experience many stressors placing them at risk for posttraumatic stress disorder (PTSD) symptoms, yet little is known about factors associated with PTSD symptoms in this population. This study explored relationships among patients' PTSD symptoms, physical and psychological symptom burden, and risk for hospital readmissions.METHODSWe prospectively enrolled patients with cancer admitted for an unplanned hospitalization from August 2015‐April 2017. Upon admission, we assessed patients' PTSD symptoms (Primary Care PTSD Screen), as well as physical (Edmonton Symptom Assessment System [ESAS]) and psychological (Patient Health Questionnaire 4 [PHQ‐4]) symptoms. We examined associations between PTSD symptoms and patients' physical and psychological symptom burden using linear regression. We evaluated relationships between PTSD symptoms and unplanned hospital readmissions within 90‐days using Cox regression.RESULTSWe enrolled 954 of 1,087 (87.8%) patients approached, and 127 (13.3%) screened positive for PTSD symptoms. The 90‐day hospital readmission rate was 38.9%. Younger age, female sex, greater comorbidities, and genitourinary cancer type were associated with higher PTSD scores. Patients' PTSD symptoms were associated with physical symptoms (ESAS physical: B = 3.41; P < .001), the total symptom burden (ESAS total: B = 5.97; P < .001), depression (PHQ‐4 depression: B = 0.67; P < .001), and anxiety symptoms (PHQ‐4 anxiety: B = 0.71; P < .001). Patients' PTSD symptoms were associated with a lower risk of hospital readmissions (hazard ratio, 0.81; P = .001).CONCLUSIONSA high proportion of hospitalized patients with cancer experience PTSD symptoms, which are associated with a greater physical and psychological symptom burden and a lower risk of hospital readmissions. Interventions to address patients' PTSD symptoms are needed and should account for their physical and psychological symptom burden. Cancer 2018. © 2018 American Cancer Society.
Engaging Disturbing Books
Authors: Ivey Gay , Johnston Peter 
Published: June 2018

AbstractThere is evidence that student‐selected reading of compelling, relevant young adult literature helps address the problem of low reading engagement among adolescents, but schools rarely take up this option as a curricular priority. A major source of apprehension for adults is fear that students might be placed at risk by exposure to realistic content of some young adult books or that parents might object. In this article, the authors take up this problem by describing the experiences of eighth‐grade students in classes where engaged reading of disturbing books was the norm. The authors offer students’ perspectives, as well as those of some of their parents. Students documented the many positive ways that they were transformed by the books and the ensuing conversations. Their parents agreed and described resulting changes in family conversations and relationships.
Simultaneous downregulation of miR‐21 and miR‐155 through oleuropein for breast cancer prevention and therapy
Authors: Abtin Maryam , Alivand Mohammad R. , Khaniani Mahmoud S. , Bastami Milad , Zaeifizadeh Mohammad , Derakhshan Sima M. 
Published: June 2018

AbstractBreast cancer (BC) is the leading cause of cancer mortality in women worldwide. It recently was proven that miRNAs play a critical role in BC development. The use of natural agents for control of cancer by modulating miRNAs is promising. Oleuropein is a natural polyphenolic agent with anti‐neoplastic properties and is well tolerated by humans. This study was undertaken to determine the therapeutic effects of oleuropein through modulation of master oncomiRs (miR‐21 and miR‐155) in BC cells. The present study provides the first link between miRNA and oleuropein as a mechanism in BC. MCF‐7 cells were tested with and without oleuropein and the cell viability, apoptosis, and migration were examined. The effect of oleuropein on miR‐21 and miR‐155 expression was assessed through qRT‐PCR. It was found that oleuropein induced apoptosis and retarded cell migration and invasion in a dose‐dependent manner in the human MCF7 BC cell line. It was observed that oleuropein significantly decreased expression of both miR‐21 and miR‐155 over time in a dose‐dependent manner. These results demonstrate that oleuropein is a potential therapeutic and preventive agent for BC. Oleuropein exhibits an anti‐cancer effect by modulation of tumor suppressor gene expression, which is targeted by oncomiRs.
FGF9‐induced ovarian cancer cell invasion involves VEGF‐A/VEGFR2 augmentation by virtue of ETS1 upregulation and metabolic reprogramming
Authors: Bhattacharya Rahul , Ray Chaudhuri Susri , Roy Sib S. 
Published: June 2018

AbstractOvarian cancer (OC) renders its lethality to enhanced metastasis and late detection. A plethora of growth factors including Vascular Endothelial Growth Factor (VEGF) and Fibroblast Growth Factor (FGF) stimulated signaling pathways regulate the invasive/metastatic behavior of ovarian tumors contributing to its aggressiveness. Autocrine VEGF‐functioning by virtue of upregulated VEGFR2 contributes to the invasiveness of OC cells by modulating the MMPs. Studies have highlighted the interaction between FGF and VEGF signaling pathways during angiogenesis. Moreover, the previous involvement of FGF9 in controlling the OC invasiveness prompted us to investigate its role in regulating VEGF‐A/VEGFR2 expression that may control the invasive behavior of the cells. Here we demonstrate that, FGF9‐induction resulted in the augmentation of VEGF‐A/VEGFR2 levels and the subsequent invasion of OC cells through the activation of the ERK‐signaling pathway. Moreover, the ETS1 transcription factor was found to enhance the VEGFA/VEGFR2 expression by directly binding to their promoters and facilitated FGF9‐dependent elevation of VEGF‐signaling which augmented the metastatic potential of OC cells. Enhanced cellular invasiveness was associated with increased aerobic glycolysis, LDH‐A expression, and lactate production. Lactate, in turn, controlled VEGF‐A/VEGFR2 expression and the resulting cell invasion. Taken together, the augmentation of VEGF‐A/VEGFR2 expression and subsequent invasion of OC cells were governed by FGF9‐dependent enhancement of both ETS1 and LDH‐A/lactate levels. Therefore, this study provides an insight into the mechanism governing elevated VEGF‐autocrine functioning in OC that contributes to its invasive/metastatic behavior.
Hypoxia inducible factor‐1α/vascular endothelial growth factor signaling activation correlates with response to radiotherapy and its inhibition reduces hypoxia‐induced angiogenesis in lung cancer
Authors: Zhu Hongjun , Zhang Shuanglin 
Published: June 2018

AbstractLike other tumors, lung cancer must induce angiogenesis as it grows. Hypoxia‐inducible factor 1α (HIF‐1α) is the inducible subunit of the HIF‐1 transcription factor that regulates genes involved in the response to hypoxia, some of which contributes to angiogenesis. Vascular endothelial growth factor (VEGF) is one of the genes upregulated by HIF‐1 and is the primary cytokine in relation to angiogenesis. In this study we tested whether aberrant activation of hypoxia inducible factor‐1α/vascular endothelial growth factor (HIF‐1α/VEGF) pathway correlates with response to radiotherapy and examined the response of lung cancer cells to hypoxia in vitro. We determined increased expressions of HIF‐1α and VEGF‐A in 76 cancerous tissues of responders (complete remission and partial remission). HIF‐1α and VEGF‐A were shown to be upregulated in lung cancer cells in response to hypoxia. The treatment with anti‐HIF‐1α siRNA prior to hypoxia exposure was shown to decrease HIF‐1α and VEGF‐A expressions and reduce hypoxia‐induced angiogenesis, suggesting that HIF‐1α expression resulted in increased VEGF‐A expression and activation of HIF‐1α/VEGF pathway was responsible for hypoxia‐induced angiogenesis. In conclusion, we identified the relationship between HIF‐1α/VEGF pathway and response to radiotherapy and its role in angiogenesis in lung cancer in vitro. HIF‐1α/VEGF pathway as a target for antiangiogenic treatment strategies for this tumor requires further investigation.
The Nogo‐B receptor promotes human hepatocellular carcinoma cell growth via the Akt signal pathway
Authors: Dong Chengyong , Liu Ying , Jiang Keqiu , Wang Haibo , Qu Weikun , Zhang Chi , Liang Rui , Gao Zhenming , Zhao Baofeng , Miao Qing , Shao Shujuan , Wang Liming 
Published: June 2018

AbstractNogo‐B receptor (NgBR) is a type I receptor with a single transmembrane domain and specifically binds to ligand Nogo‐B. A previous study demonstrated that NgBR was highly expressed in human breast invasive ductal carcinoma and promoted epithelial‐mesenchymal transition in breast tumor cells. Our recent work found that NgBR expression was associated with a poor prognosis in human patients with hepatocellular carcinoma (HCC). Here, we elucidate that the increased expression of NgBR contributes toward the increased cell growth of human HCC cells both in vitro and in vivo. Cell viability and clonogenic survival analysis results demonstrated that knockdown of NgBR inhibits the cell growth in human HCC cells, which correlates with a reduction in the phosphorylation of Akt levels. Furthermore, overexpression of NgBR by the cotransfected pIRES‐NgBR plasmid together with NgBR siRNA in human HCC cells can rescue impaired phosphorylation of Akt levels in NgBR knockdown human HCC cells. In addition, cell viability analyses showed that NgBR overexpression can rescue the cell growth inhibition presented in human HCC NgBR knockdown cells. Taken together, our results suggest that NgBR potentially acts as an oncogene in HCC by increasing Akt activity. Thus, NgBR may represent a new potential diagnostic and therapeutic target for the treatment of HCC.
Magnetic resonance cold pressor test to investigate potential endothelial dysfunction in patients suffering from type 1 diabetes
Authors: Weng Andreas M. , Wilimsky Stefan , Bender Gwendolyn , Hahner Stefanie , Köstler Herbert , Ritter Christian O. 
Published: June 2018

BackgroundIn its course, diabetes impairs microvascular function through endothelial dysfunction. As the response of myocardial perfusion to sympathetic stimulation through cold is modulated by endothelium‐related factors, an incipient endothelial dysfunction might be observed noninvasively by investigation of myocardial perfusion with a cold pressor test (CPT). This approach has been used in clinical MRI previously.PurposeTo assess endothelial function of patients suffering from type 1 diabetes by MR CPT.Study TypeProspective cohort study.SubjectsTwenty type 1 diabetics and 20 healthy volunteers.Field Strength/Sequence3T, dynamic contrast enhanced perfusion (steady‐state free precession).AssessmentAbsolute quantitative myocardial perfusion values at rest and under CPT.Statistical TestsKolmogorov–Smirnov test to determine normal distribution of the results. T‐test for independent samples.ResultsPatients' mean myocardial perfusion was 0.68 cc/g/min at rest and 0.80 cc/g/min during CPT, respective values of 0.81 cc/g/min and 1.36 cc/g/min were found in healthy volunteers. Perfusion values differed significantly for CPT (P < 0.01) but not for resting conditions (P = 0.06).Data ConclusionThis study demonstrated that endothelial function might be impaired in type 1 diabetes patients. This fosters the thesis that endothelial function may serve as an early biomarker for coronary artery disease in patients with type 1 diabetes while these patients are still clinically asymptomatic.Level of Evidence: 2Technical Efficacy: Stage 3J. Magn. Reson. Imaging 2018;48:1595–1601
A multiband self‐complementary SRR loaded dipole antenna
Authors: Rajendran Jolly , Menon Sreedevi K. 
Published: June 2018

AbstractIn this article, a novel self‐complimentary, split ring resonator‐loaded dipole antenna (SCSDA) is proposed, which could be used in L and S bands. The proposed antenna consists of U‐shaped dipoles loaded with split ring resonators. Along with the dipoles, SRRs excites additional resonances yielding multi‐band operation. The measured average gain is 7 dBi across the bandwidth for the antenna. The measured results confirm that SCSDA is a multiband antenna and can be a good candidate for L and S band applications.
Performance comparison of liquid level sensors using fiber coupler and fiber‐bundled probe
Authors: Samian Samian , Zaidan Andi , Yasin Moh , Sujito Sujito 
Published: June 2018

AbstractDetection liquid level using fiber coupler, a pair, and concentric bundled probes has been demonstrated. The detection mechanism is based on displacement sensor and utilizing the principle of hydrostatic pressure. The results indicate that the concentric bundled probe has the best performance with a sensor range of 130 cm.
Characterization of horn antenna loaded with CLL unit cell
Authors: Lashab Mohamed , Zebiri Chess‐Eddine , Djouablia Linda , Belattar Mounir , Saleh Adham , Benabdelaziz Fatiha , Abd‐Alhameed Read 
Published: June 2018

AbstractIn this paper, a pyramidal horn antenna loaded with unit cell of metamaterial is proposed, designed and realized for L‐band that including terrestrial digital audio broadcasting T‐DAB, GPS, and GSM. The proposed antenna operates in the frequency range from 1.722 to 1.931 GHz. The metamaterial is fabricated on a printed circuit board as Capacitive Loaded Loop (CLL). The work aims to exhibit the advantage of metamaterial loaded inside the horn antenna in terms of the gain enhancement of the radiation pattern and the resonant frequency shift toward lower frequency. The retrieval technique used show that the constitutive parameters of the unit cell as CLL have a zero index metamaterial (ZIM) from 1.34 to 1.49 GHz and a near zero index of refraction from 1.495 GHz to 2 GHz, which is within the operating frequency of the horn antenna. The achieved results show that the total gain is improved over the frequency range. The simulation and the measurement are in good agreement.
Waveform comparison and PA nonlinearity effects on CP‐OFDM and 5G FBMC wireless systems
Authors: Bozic M. , Barjamovic D. , Cabarkapa M. , Budimir D. 
Published: June 2018

AbstractIn this article, a waveform comparison and power amplifier nonlinearity effects on cyclic prefix orthogonal frequency‐division multiplexing (CP‐OFDM) and 5G filter bank multicarrier (FBMC) wireless systems are presented. The 5 MHz CP‐OFDM and 5G FBMC signals are used in Matlab simulations, while 1.4 and 3 MHz of both signals are used in experiment. It is noted that 1.4 and 3 MHz CP‐OFDM signals have larger side‐lobes in comparison with 5G FBMC signals. The 5G FBMC signals have stepper slope at the edges and very low out‐of‐band leakage.
Design of a wideband bowtie antenna using a modified T‐shaped slot
Authors: Park Jae Sung , Choi Hak Keun 
Published: June 2018

AbstractThis article proposes a bowtie antenna with a modified T‐slot and compares it with a normal slot antenna and a T‐slot antenna in terms of wideband characteristics. The proposed antenna is a simplified version of the bowtie dipole antenna with a reflector. The proposed antenna obtains wideband characteristics by adding a T‐shaped slot, whose width is gradually increased toward the ends of the antenna, to the slot dipole antenna. The proposed antenna also has the radiating element of a bowtie form that decreases return loss at the frequencies above 2 GHz. As the proposed antenna has a simple structure, it can achieve the desired wideband characteristics with a small number of parameters. Its height is λ/5 of the center frequency, so it is a low‐profile antenna. The return loss of the proposed antenna is below −15 dB at 1.6–2.7 GHz. Despite a low‐profile antenna often having a small gain, the gain of the proposed antenna reaches up to 7.5‐9 dBi. The proposed antenna shows little variation over the operating frequency range, which makes it suitable for wideband applications.
Realization of a dual mode filter in ridge gap waveguide technology
Authors: Hassani Najme , Ostovarzadeh Mohamad Hossein , Razavi Seyed Ali 
Published: June 2018

AbstractA proof of concept of a dual mode filter based on ridge gap waveguide cavity is presented by introducing perturbation to one of the first two degenerate modes. Rectangular, circular, and elliptical shaped perturbations are investigated. The one with elliptical perturbation was fabricated and tested. Good agreement between measured and simulation results was observed.
Directive planar antenna array fed by dielectric waveguide for WiFi applications
Authors: Kong Linghui , Yan Sen , Vandenbosch Guy A. E. 
Published: June 2018

AbstractA 1‐D nonuniform antenna array fed by a dielectric waveguide operating at 5.7 GHz is proposed. Based on the electromagnetic coupling between the inside travelling wave and the antenna elements, a broadside directive radiation pattern is obtained. The presence of a ground plane allows wall mounting, which is advantageous in many wireless fidelity applications. A prototype was built and measured to prove the concept. The measured −6 dB bandwidth is ca. 150 MHz and the measured realized gain is 9.58 dBi in the broadside direction. This is a very reasonable performance for an extremely simple structure, without feeding network, which is easily manufactured with cheap mass‐production Printed Circuit Board technology.
A broadband dual‐polarized multi‐dipole antenna fed by coplanar stripline
Authors: Chen Yanzheng , Lin Wenbin , Liao Cheng , Kan Guojin , Raza Ali 
Published: June 2018

AbstractA simple wideband dual‐polarized multi‐dipole antenna fed by coplanar stripline is proposed in this article. An enhanced impedance bandwidth of about 43.5% is achieved with this antenna for VSWR < 1.5 and gain > 8 dBi at 2 ports, covering the operating frequency region from 1.69 to 2.63 GHz. The radiation pattern is measured and 3‐dB beamwidths of 64 ± 3 degree at E‐plane and 54 ± 6 degree at H‐plane for port 1 and 65 ± 4 degree at E‐plane and 54 ± 5 degree at H‐plane for port 2 are acquired. The port‐to‐port isolation is above 25 dB. This model has been manufactured and measured. The experimental results show good amount of similarity with simulated ones.
A miniaturized slotted ground structure UWB antenna for multiband applications
Authors: Ali Tanweer , AW Mohammad Saadh , Biradar Rajashekhar C. , Andújar Aurora , Anguera Jaume 
Published: June 2018

AbstractA concept of using slots both in the radiator and in the ground to miniaturize an ultrawideband (UWB) antenna in order to operate at multiband is demonstrated. Initially, a miniaturized circular UWB antenna is designed which results in about 53.5% reduction in total volume and about 46.6% in the active patch area, in comparison to the conventional UWB antenna. To reconfigure the proposed UWB antenna to operate in multiband applications, slotted ground approach is used. The slots in the ground plane of the proposed design affects the surface current distribution due to which the designed antenna operates at 3.7 (middle WiMAX), 5.7 (upper WiMAX), and 7.5 GHz (X‐band) with −10 dB reflection coefficient bandwidth of about 5.3% (3.64–3.84 GHz), 5.5% (5.64–5.96 GHz), and 3.7% (7.44–7.72 GHz), respectively. The proposed configuration is compact in size with a total area of only 0.26λ0 × 0.21λ0 = 30 × 24.8 = 283.3
at lower resonating band of 2.6 GHz. The designed multiband structure yields good impedance matching, acceptable gain and stable radiation characteristics both in xz and yz plane, across their operational bandwidths.