bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptability and Appropriateness of a Perinatal Depression Preventive Group Intervention: A Qualitative Analysis
Authors: Diebold Alicia , Segovia Melissa , Johnson Jessica K. , Degillio Aria , Zakieh Dana , Park Hee Jin , Lim Kenneth , Tandon S. Darius 
Published: July 2019

Abstract
Background

Perinatal depression is a prevalent public health concern. Although preventive interventions exist, there is limited literature on the acceptability and appropriateness of these interventions, especially those delivered by paraprofessionals. The Mothers and Babies Program (MB) is a group-based perinatal depression preventive intervention delivered prenatally. A current cluster-randomized controlled trial is examining the acceptability, appropriateness, and effectiveness of MB delivered by mental health professionals compared to paraprofessional staff from home visiting programs.

Methods

The full study enrolled 874 pregnant women. Fifty-three facilitators were trained and delivered the MB intervention. Semi-structured interviews were attempted with a randomly-selected subset of the full sample of pregnant women who received the MB intervention and with all facilitators. Specifically, interviews were conducted with 88 women who received the MB group intervention (45 in the paraprofessional-led arm and 43 in the mental health professional-led arm) and 46 women who facilitated the groups (27 home visiting staff and 19 mental health professionals). Interviews were conducted over the phone in English or Spanish and audio recorded. The recordings were translated into English, as needed, and transcribed. Thematic analysis was conducted using NVIVO to identify key themes related to intervention acceptability and appropriateness. Similarities and differences between study arms were explored.

Results

Clients and facilitators found the MB content and group format acceptable. Challenges included maintaining group attendance, transportation issues, and managing group discussion. Overall, facilitators found the intervention appropriate for pregnant clients with some challenges presented for clients in crisis situations, experiencing housing instability, and with literacy and learning challenges. Participants provided suggestions for improvement, both for the course content and implementation. There were no significant differences found between study arms.

Conclusions

Overall, clients and facilitators enjoyed MB irrespective of study arm, and facilitators found the intervention appropriate for the population. These findings add to the qualitative literature on perinatal depression preventive interventions, specifically those delivered by paraprofessionals.
Anesthesia and mHealth - a Survey
Authors: Carvalho Hugo , Verdonck Michael , Forget Patrice , Poelaert Jan 
Published: July 2019

Abstract
Background

mHealth, the practice of medicine aided by mobile devices is a growing market. Although the offer on Anesthesia applications (Apps) is quite varied, representative formal assessments on the views of anesthesia practitioners on its use and potential place in daily practice is lacking. This survey aimed thus to cross-assess the Belgian anesthesia population on the use of smartphone Apps and peripherals.

Methods

The survey was exclusively distributed as an online anonymous questionnaire. Sharing took place via hyperlink forwarding by the Belgian Society for Anesthesia and Reanimation (BSAR) and by the Belgian Association for Regional Anesthesia (BARA) to all registered members. The first answer took place on 5 September 2018, the last on 22 January 2019.

Results

349 answers were obtained (26.9% corresponding to trainees, 73.1% to specialists). Anesthesiologists were positively confident that Apps and peripherals could help improve anesthesia care (57.0% and 47.9%, respectively, scored 4 or 5, in a scale from 0 - 5). Anesthesia trainees were significantly more confident that specialists on mobile Apps (72.1% and 51.6%, respectively).

The usefulness of Apps and Peripherals was rated 1 or below (on a 0 to 5 scale) by 9.5% and 14.6% of the subjects. Trainees significantly used mobile apps more than specialists (66.7% vs. 37.4%, respectively).

The preferred category of mobile Apps was dose-calculating applications (39.8%), followed by digital books (21.5%) and Apps for active perioperative monitoring (20.3%).

Conclusions

Belgian Anesthesia practitioners show a significant positive attitude towards smartphone Apps and Peripherals.
Identifying asymptomatic infections of visceral leishmaniasis in non-endemic regions with the associated risk factors in Gedaref state, Sudan
Authors: Mohamed Nouh Saad , Osman Hussam A. , Muneer Mohamed S. , Samy Abdallah M. , Ahmed Ayman , Mohammed Anwar O. , Siddig Emmanuel Edwar , Elaagip Arwa H. 
Published: July 2019

Abstract
Objectives

Visceral Leishmaniasis (VL) can be symptomatic and asymptomatic infection. In this study we aimed at investigating the prevalence of asymptomatic infections and to study risk factors of VL in non-endemic regions in Gedaref state, Sudan. A descriptive cross-sectional study conducted during 2014. Blood samples were collected to serological and molecular analysis. Sticky traps, knockdown spray and CDC miniature light traps were used for the collection of sandflies.

Results

Ninety-Five participants were included; 52 from Abukishma, 15 Algadamblia Tirfa, 25 Abualnaja and 3 were from Algadamblia Aljabal. Most of the study participants were belonging to the Belala tribe (74.3%). The most frequent reported age was above 40-years old (9.5%). Females were (61.1%) and males were (38.9%). B. aeygptica was the most planted tree in/around the houses (46.3%). 73 (76.8%) of the participants bred more than two types of animals in the house. DAT test revealed 5 positive participants (5.2%). 4/5 DAT positive were past VL infection. PCR detected 35 (36.8%) positive patients. A total of 31 (32.6%) were considered asymptomatic infections based on PCR detection method. Households planted Balanites/Acacia trees or breed domestic animals were found in high percentages with VL PCR positive participants (60.1%, 91.4%).
Low Partner Testing in High HIV Prevalence Setting in Freetown, Sierra Leone: A Retrospective Study
Authors: Lakoh Sulaiman , Firima Emmanuel , Jiba Darlinda F. , Sesay Momodu , Conteh Mariama Marco , Deen Gibrilla Fadlu 
Published: July 2019

Abstract
Objective: Our study aimed at assessing partner testing and HIV prevalence among individuals tested at an urban tertiary hospital in Sierra Leone.
Results: Of the 3808 clients tested for HIV at Connaught Hospital in Freetown from January to December 2017, 2048(53.8%) were females. Median age was 31 (IQR 24 – 42) years and 2104 (55.3%) were single. While 3014(79.1%) had Provider Initiated Testing and Counselling (PITC), 794 (20.9%) had Client Initiated Testing and Counselling (CITC). HIV test was positive in 925 (24.3%) {CI 22.9 – 25.6, P= 0.00} clients. Of the 17 (0.4%) partners tested for HIV, 9 (52.9%) were positive. PITC yielded more HIV positive cases (760, 25.2%) than CITC (165, 20.8%). Partner testing (CI: 1.45 – 10.20, P=0.007), female sex (CI: 1.32 – 1.80, P=0.000) and PITC (CI: 1.08 – 1.61, p=0.006) were associated with a positive HIV diagnosis. With demonstrated high HIV prevalence and low partner testing, we recommend for stakeholders in the HIV response to address the address the challenges of disclosure and adopt new HIV testing approaches.
Prevalence and Mortality of Cryptococcal Disease in Adults with Advanced HIV in an Urban Tertiary Hospital in Sierra Leone: A Cross Sectional Study
Authors: Lakoh Sulaiman , Rickman Hannah , Sesay Momodu , Kenneh Sartie , Burke Rachael M. , Baldeh Mamadu , Jiba Darlinda Fatmata , Tejan Yusuf Sheku , Boyle Sonia , Koroma Comfort , Deen Gibrilla Fadlu , Beynon Fenella 
Published: July 2019

Abstract
Background
The global annual estimate for cryptococcal disease related deaths exceeds 180,000, with three fourth occurring in sub-Saharan Africa. The World Health Organization (WHO) recommends cryptococcal antigen (CrAg) screening in all HIV patients with CD4 count <100/µl. As there is no previous published study on the burden and impact of cryptococcal disease in Sierra Leone, research is needed to inform public health policies. We aimed to establish the seroprevalence and mortality of cryptococcal disease in adults with advanced HIV attending an urban tertiary hospital in Sierra Leone.
Methods: A cross-sectional study design was used to screen consecutive adult (18 years or older) HIV patients at Connaught Hospital in Freetown, Sierra Leone with CD4 count below 100 cells/mm3 from January to April, 2018. Participants received a blood CrAg lateral flow assay (IMMY, Oklahoma, USA). All participants with a positive serum CrAg had lumbar puncture and cerebrospinal fluid (CSF) CrAg assay, and those with cryptococcal diseases had fluconazole monotherapy with eight weeks followed up. Data were entered into Excel and analysed in Stata version 13.0. Proportions, median and interquartile ranges were used to summarise the data. Fisher’s exact test was used to compare categorical variables.
Results
A total of 170 patients, with median age of 36 (IQR 30-43) and median CD4 count of 45 cells/mm3 (IQR 23-63) were screened. At the time of enrolment, 54% were inpatients, 51% were newly diagnosed with HIV, and 56% were either ART-naïve or newly initiated (≤ 30 days). Eight participants had a positive blood CrAg, giving a prevalence of 4.7% (95% CI: 2.4-9.2%). Of those with a positive CrAg, CSF CrAg was positive in five (62.5%). Five (62.5%) CrAg-positive participants died within the first month, while the remaining three were alive and established on ART at eight weeks.
Conclusion: A substantial prevalence of cryptococcal antigenaemia and poor outcome of cryptococcal diseases were demonstrated in our study. The high mortality suggests a need for the HIV programme to formulate and implement policies on screening and pre-emptive fluconazole therapy for all adults with advanced HIV in Sierra Leone, and advocate for affordable access to effective antifungal therapies.
Cystic duct dysplasia after cholecystectomy: a systematic review of the literature
Authors: Mongelli Francesco , Cianfarani Agnese , Giuseppe Matteo Di , Vajana Antonjacopo Ferrario Di Tor , Saporito Andrea , Garofalo Fabio , Regina Davide La 
Published: July 2019

Abstract
Purpose

Approximately 1 to 3.5% of cholecystectomies are found to have incidental dysplasia on histological examination. Cases of positive resection margins on the cystic stump are rare and evidence lack. The aim of this article was to systematically review the literature and to suggest a possible management algorithm.

Methods

We searched PubMed, Cochrane Library and Google Scholar databases by combining “cholecystectomy” AND “dysplasia” AND “cystic” according to PRISMA guidelines. Studies providing information about cystic duct dysplasia with positive resection margin after cholecystectomy were included.

Results

The searches identified 109 articles from PubMed and 4 articles from Cochrane Library and Google Scholar, of which three were eligible. Five were found to have post-operative high-grade dysplasia, one patient had a carcinoma and one had a low-grade dysplasia. Median follow-up was of 10.5 months (range: 0.5 – 26.6 months), no evidence of recurrence was found in patients with dysplasia, while the patient with diagnosis of cholangiocarcinoma died during follow-up.

Conclusions

Patients with positive resection margins for dysplasia after cholecystectomy should be considered for a surgical treatment. The latter depends on several factors related to the patient and the grade of dysplasia itself. Simple cystic duct stump excision has been suggested and it seems to be safe and effective with no evidence of recurrence during follow-up when a R0 resection is achieved. A multidisciplinary approach and a surveillance program should be always taken into account.
A Discrete Limit Theorem for L-Functions of Elliptic Curves
Authors: Garbaliauskienė Virginija , Garbaliauskas Antanas 
Published: July 2019

In the paper, we prove the discrete limit theorem in the sense of the weak convergence of probability measures in the space of analytic on DV = {s ∈ C : 1 < σ < 3/2, |t| < V} functions for L-functions of elliptic curves LE(s). The main statement of the paper is as follows. Let h > 0 be a fixed real number such that exp {2πk/h} is an irrational number for all k∈Z\{0}. Then the probability measure μN(LE(s + imh)∈A), A ∈ B(H(DV)), converges weakly to the measure PLE as N→∞.
KEPUASAN PASIEN STROKE PESERTA JKN DI RS LESTARI RAHARJA DAN RSUD MUNTILAN KABUPATEN MAGELANG
Authors: Wibawa Eka Ari , Kuntjoro Tjahjono , Pinzon Rizaldy Taslim 
Published: July 2019

Latar Belakang: Stroke merupakan penyebab kematian nomor tiga, setelah
penyakit jantung dan kanker. Stroke juga merupakan penyebab utama kecacatan
fisik maupun mental pada usia lanjut dan produktif. Jumlah penderita stroke di
Indonesia semakin bertambah dan diderita oleh semua lapisan masyarakat.
Keadaan tersebut harus mendapatkan perhatian, sehingga penanganan penderita
stroke diharapkan dilakukan dengan suatu standar yang pasti. Pelayanan yang
dilakukan dengan standar akan menghasilkan mutu pelayanan rumah sakit yang
dapat dipertanggungjawabkan dan pada akhirnya memunculkan kepuasan
pasien.
Tujuan: Tujuan dari penelitian ini adalah membandingkan kepuasan
pasien penderita stroke peserta Jaminan Kesehatan Nasional (JKN) terhadap
mutu pelayanan RS Lestari Raharja Magelang dan RSUD Muntilan Kabupaten
Magelang.
Metode: Penelitian ini merupakan penelitian relational, dengan disain
penelitian kombinasi model concurrent embedded. Instrumen yang digunakan
dalam penelitian ini adalah menggunakan kusioner tertutup yang telah dipakai
oleh peneliti sebelumnya dan pedoman wawancara yang disusun semi struktural,
yaitu berupa pertanyaan-pertanyaan yang digunakan untuk mendapatkan
informasi lebih mendalam tentang faktor kepuasan pasien secara umum maupun
berdasarkan 5 aspek; penampilan fisik, kemampuan pelayanan yang akurat, daya
tanggap, jaminan dan empati kepada pasien/ keluarga pasien penderita stroke di
rumah sakit.
Hasil: Hasil penelitian menunjukkan bahwa 82,4% pasien penderita stroke
di RSUD Muntilan Kabupaten Magelang dan 74,2% pasien penderita stroke di RS
Lestari Raharja yang merupakan peserta JKN menyatakan puas terhadap
pelayanan rumah sakit. Hasil analisa bivariat hubungan jenis rumah sakit
terhadap kepuasan pasien menunjukkan tidak ada hubungan yang signifikan (OR
1,63, 95% CI 0,51-4,90 dan p value 0,33). Hasil analisa multivariat pengaruh jenis
rumah sakit terhadap kepuasan pasien menunjukkan tidak ada hubungan yang
signifikan antara jenis rumah sakit terhadap kepuasan pasien (OR 1,38, 95%CI
0,36-5,28 dan p value 0,63).
Kesimpulan: Penelitian ini menunjukkan tidak ada perbedaan kepuasan
pasien penderita stroke yang dirawat di RS Lestari Raharja dan RSUD Muntilan
Kabupaten Magelang serta tidak ada hubungan antara jenis rumah sakit terhadap
kepuasan pasien.
Efficiency of endovascular embolization and predictors of postoperative complications in patients with different types of brain arteriovenous malformations
Authors: Brusyanskaya A. , Krivoshapkin A. , Orlov K. , Alshevskaya A. , Moskalev A. , Sergeev G. , Gaytan A. , Simonovich A. 
Published: July 2019

Aim. (1) To evaluate the efficiency of endovascular embolization of brain arteriovenous malformations (AVMs) with seizure or hemorrhage in relation to radicalness and postoperative complication development and (2) to determine the predictors of postoperative complications after endovascular embolization of AVMs.
Methods. In this retrospective study, we examined the treatment of 192 patients with brain AVMs with seizure (seizure group; n = 85) or hemorrhage (hemorrhage group; n = 107). All the patients underwent total endovascular embolization of the malformations, and the follow-up period was 12 months. The two different patient groups were identified, and the predictors of the development of adverse events (hemorrhagic and ischemic complications) in the early postoperative period (hospital stay) were determined.
Results. Twelve months after control cerebral angiography was performed, recanalization was observed in 7 (8.2%) and 14 (13.1%) patients in the seizure and hemorrhage groups, respectively (p = 0.432). The frequency of complications was 20% and 29.9% in the seizure and hemorrhage groups, respectively (p = 0.162). The mortality rate during hospitalization was 0% and 9.3% in the seizure and hemorrhage groups, respectively (p = 0.026). Multivariate regression analysis revealed that a history of hemorrhage, the location of AVMs in functionally significant zones, and a large maximum size of AVMs are predictors of the development of postoperative complications.
Conclusion. Endovascular embolization is an effective, minimally invasive approach for the treatment of different types of brain AVMs. Considering the natural risks of brain AVMs according to the literature, endovascular embolization is associated with a low frequency of early postoperative complications.
Received 14 February 2019. Revised 24 May 2019. Accepted 28 May 2019.
Funding: The study did not have sponsorship.
Conflict of interest: Authors declare no conflict of interest.
Inhibition of miR-223 Expression Using a Sponge Strategy Decreases Restenosis in Rat Injured Carotids
Authors: M’baya-Moutoula Eleonore , Marchand Alexandre , Six Isabelle , Bahrar Noura , Celic Tanja , Mougenot Nathalie , Maitrias Pierre , Massy Ziad A. , Lompré Anne-Marie , Metzinger Laurent , Metzinger-Le Meuth Valérie 
Published: July 2019

Objective:
Restenosis is a frequent complication of angioplasty. It consists of a neointimal
hyperplasia resulting from progression and migration of vascular smooth muscle cells (VSMC) into the
vessel lumen. microRNA miR-223 has recently been shown to be involved in cardiovascular diseases
including atherosclerosis, vascular calcification and arterial thrombosis. In this study, our aim was to
assess the impact of miR-223 modulation on restenosis in a rat model of carotid artery after balloon
injury.

Methods:
The over and down-expression of miR-223 was induced by adenoviral vectors, containing
either a pre-miR-223 sequence allowing artificial miR-223 expression or a sponge sequence, trapping
the native microRNA, respectively. Restenosis was quantified on stained rat carotid sections.

Results:
In vitro, three mRNA (Myocyte Enhancer Factor 2C (MEF2C), Ras homolog gene family,
member B (RhoB) and Nuclear factor 1 A-type (NFIA)) reported as miR-223 direct targets and known
to be implicated in VSMC differentiation and contractility were studied by RT-qPCR. Our findings
showed that down-expression of miR-223 significantly reduced neointimal hyperplasia by 44% in carotids,
and was associated with a 2-3-fold overexpression of MEF2C, RhoB and NFIA in a murine monocyte
macrophage cell line, RAW 264.7 cells.

Conclusions:
Down-regulating miR-223 could be a potential therapeutic approach to prevent restenosis
after angioplasty.
Theoretical Studies on the Selectivity Mechanisms of Glycogen Synthase Kinase 3β (GSK3β) with Pyrazine ATP-competitive Inhibitors by 3DQSAR, Molecular Docking, Molecular Dynamics Simulation and Free Energy Calculations
Authors: Zhu Jingyu , Wu Yuanqing , Xu Lei , Jin Jian 
Published: July 2019

Background:
Glycogen synthase kinase-3 (GSK3) is associated with various key biological processes
and has been considered as an important therapeutic target for the treatment of many diseases. Great
efforts have been made on the development of GSK3 inhibitors, especially ATP-competitive GSK3β inhibitor,
but it is still a great challenge to develop selective GSK3β inhibitors because of the high sequence
homology with other kinases.

Objective:
In order to reveal the selectivity mechanisms of GSK3β inhibition at the molecular level, a series
of ATP-competitive GSK3β inhibitor was analyzed by a systematic computational method, combining 3DQSAR,
molecular docking, molecular dynamic simulations and free energy calculations.

Methods:
Firstly, 3D-QSAR with CoMFA was built to explore the general structure activity relationships.
Secondly, CDOCKER and Flexible docking were employed to predicted the reasonable docking poses of
all studied inhibitors. And then, both GSK3β and CDK2 complexes were selected to conduct molecular dynamics
simulations. Finally, the free energy calculations were employed to find the key selective-residues.

Results:
CoMFA model suggested the steric, hydrophobic fields play key roles in the bioactivities of inhibitors,
and the binding mechanisms were well analyzed through molecular docking. The binding free energies
predicted are in good agreement with the experimental bioactivities and the free energy calculations
showed that the binding of GSK3β/inhibitors was mainly contributed from hydrogen bonding and hydrophobic
interaction.

Conclusion:
Some key residues for selective binding were highlighted, which may afford important guidance
for the rational design of novel ATP-competitive GSK3β inhibitors.
Levofloxacin-induced Desquamation: A Possible and Rare Case Report
Authors: Gill Gurleen Kaur , Chhabra Manik , Chawla Sumit Pal Singh 
Published: July 2019

Introduction:Levofloxacin is a fluoroquinolone active against both gram-negative and gram-positive bacteria with a well-defined margin of safety and efficacy. It has various labeled adverse effects like other fluoroquinolones but its adverse effect like desquamation is rarely reported.Methods:We present a case report of levofloxacin-induced desquamation in an Indian patient.Case Report:A-38-year old female patient presented to the outpatient department, with chief complaints of peeling off her epidermal skin. Initially, Desquamation started on her greater finger, which slowly spread to her hand, feet, lower limbs as well as upper limb and neck region. She was prescribed Levofloxacin for respiratory tract infection.Results and Discussion:Considering temporal relationship, upon causality assessment, (Adverse Drug Reaction) ADR was found to be likely, moderate and probable. The drug was withdrawn along with the initiation of supportive therapy and reaction subsided.Discussion:Although adverse drug reactions like desquamation are not fatal, this induces anxiety in the patients and reduces patient’s quality of life. This case report will help keep physicians vigilant about the current adverse drug reaction, helping in the early detection and management of ADR.