bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on Corporate Social Responsibility in Public Relations: A Hybrid Review Through Topic Modeling Analysis and Way Forward
Authors: Çelik Fatih , Koseoglu Mehmet Ali , Ibrahim Blend 
Published: November 2024

ABSTRACTDespite the growing significance of corporate social responsibility (CSR) in corporate public relations (PR) strategies, there has been a paucity of comprehensive reviews of the extant CSR literature within the PR discipline. The aim of this study is to investigate the relationship between the concept of CSR and the discipline of PR through a hybrid concept‐discipline‐focused review. We employed latent dirichlet allocation (LDA) via topic modeling as a novel approach for intellectual structure analysis. The dataset for this review comprised 246 peer‐reviewed articles on CSR published between 1975 and 2022. Based on the LDA results, five topics were identified and discussed: the political CSR stream, social media‐oriented CSR, consumer‐oriented CSR, CSR reporting, and business‐oriented CSR. Additionally, implications for both academic and practical applications were drawn, along with recommendations for future research. This study is pioneering in its contribution to the literature and practice of CSR‐related PR research, offering insights into the intellectual structures and trends within this field.
CSR Authenticity During Disruptive Events: Exploring Social Media Evaluations of Tesla's Ventilator Initiative in Response to COVID‐19
Authors: Albusaidi Saud Nasser , van den Broek Tijs , Boersma Kees 
Published: November 2024

ABSTRACTCorporate social responsibility (CSR) initiatives have increasingly become subject to authenticity evaluations on social media. Whilst CSR initiatives are evaluated as authentic if they were perceived to genuinely address societal issues and needs, it is unclear, however, how a disruptive event would change the way stakeholders perceive a company's CSR authenticity. Disruptive events have unique features of urgency, scarcity and uncertainty, which may make stakeholders expect companies to organize their CSR initiatives in different ways in order to be perceived as authentic. Hence, this study aims to explore the conceptualization of CSR authenticity during a disruptive event by analyzing social media evaluations of CSR initiatives. This paper presents the outcomes of an abductive analysis of Twitter evaluations about a respiratory‐ventilator production initiative of Tesla in response to the COVID‐19 crisis. Our findings suggest that three dimensions constitute CSR authenticity during a disruptive event: responsiveness, reliability and motivation. Disruptive events direct the attention of social media users to certain dimensions of CSR authenticity. We discuss the meaning and salience of these dimensions and conclude by implications for theory and practice.
Bringing together but staying apart: decisive differences in animal and fungal mitochondrial inner membrane fusion
Authors: Hashimi Hassan , Gahura Ondřej , Pánek Tomáš 
Published: November 2024

ABSTRACTMitochondria are dynamic and plastic, undergoing continuous fission and fusion and rearrangement of their bioenergetic sub‐compartments called cristae. These fascinating processes are best understood in animal and fungal models, which are taxonomically grouped together in the expansive Opisthokonta supergroup. In opisthokonts, crista remodelling and inner membrane fusion are linked by dynamin‐related proteins (DRPs). Animal Opa1 (optical atrophy 1) and fungal Mgm1 (mitochondrial genome maintenance 1) are tacitly considered orthologs because their similar mitochondria‐shaping roles are mediated by seemingly shared biochemical properties, and due to their presence in the two major opisthokontan subdivisions, Holozoa and Holomycota, respectively. However, molecular phylogenetics challenges this notion, suggesting that Opa1 and Mgm1 likely had separate, albeit convergent, evolutionary paths. Herein, we illuminate disparities in proteolytic processing, structure, and interaction network that may have bestowed on Opa1 and Mgm1 distinct mechanisms of membrane remodelling. A key disparity is that, unlike Mgm1, Opa1 directly recruits the mitochondrial phospholipid cardiolipin to remodel membranes. The differences outlined herein between the two DRPs could have broader impacts on mitochondrial morphogenesis. Outer and inner membrane fusion are autonomous in animals, which may have freed Opa1 to repurpose its intrinsic activity to remodel cristae, thereby regulating the formation of respiratory chain supercomplexes. More significantly, Opa1‐mediated crista remodelling has emerged as an integral part of cytochrome c‐regulated apoptosis in vertebrates, and perhaps in the cenancestor of animals. By contrast, outer and inner membrane fusion are coupled in budding yeast. Consequently, Mgm1 membrane‐fusion activity is inextricable from its role in the biogenesis of fungal lamellar cristae. These disparate mitochondrial DRPs ultimately may have contributed to the different modes of multicellularity that have evolved within Opisthokonta.
Rewired chromatin structure and epigenetic gene dysregulation during HTLV‐1 infection to leukemogenesis
Authors: Mizuike Jun , Suzuki Kako , Tosaka Shu , Kuze Yuta , Kobayashi Seiichiro , Nakashima Makoto , Jimbo Koji , Nannya Yasuhito , Suzuki Yutaka , Uchimaru Kaoru , Yamagishi Makoto 
Published: November 2024

AbstractHuman T‐cell leukemia virus type 1 (HTLV‐1) broadly impacts host genes, affecting the infected cell population and inducing the development of a disease with a poor prognosis, adult T‐cell leukemia‐lymphoma (ATL). This study aimed to provide a comprehensive epigenomic characterization of the infected cell population and evaluated the transcriptome and chromatin structures of peripheral blood cells in HTLV‐1‐infected individuals using RNA sequencing (RNA‐seq) and assay for transposase‐accessible chromatin sequencing (ATAC‐seq). The infected cells showed significant changes in gene expression patterns from the polyclonal stage and before ATL onset while demonstrating similarities to tumor‐forming ATL cells. These similarities were a result of large‐scale open chromatin changes, supporting the independent early formation of epigenomic aberrations as an underlying mechanism for later clonal propagation. This study also demonstrated that HTLV‐1 Tax directly affects the host chromatin structure, thereby developing fundamental epigenomic characteristics. Several Tax target genes, including the RASGRP3–ERK pathway, were recognized, indicating an impact on signaling pathways. This genome‐wide variability in chromatin structural property is a novel feature of HTLV‐1 infection and may contribute to pathogenic mechanisms. In addition, it has crucial implications for better understanding the impact of HTLV‐1 on the host genome and identifying novel therapeutic targets.
Association of obesity and metabolic syndrome with incident primary open angle glaucoma in the UK Biobank
Authors: Macri Carmelo Z. , Wong Christopher X. , Tu Samuel J. , Sun David F. , Casson Robert , Singh Kuldev , Wang Sophia , Sun Michelle T. 
Published: November 2024

AbstractBackgroundWe sought to investigate the association between obesity, metabolic syndrome, and metabolic health with incident primary open‐angle glaucoma (POAG).MethodsWe included 103 249 UK Biobank participants without previously diagnosed glaucoma or glaucoma‐related procedures at enrolment. The primary outcome was POAG identified from diagnostic coding via linked hospital inpatient and primary care data. We used multivariable Cox regression to evaluate the association of body mass index (BMI), and the interaction with metabolic syndrome (MetS) and a novel definition of metabolic health status with incident POAG. BMI was modelled as a time‐varying coefficient. Multivariable analysis was adjusted for age, sex, ethnicity, intraocular pressure, spherical equivalent, polygenic risk score and stratified by the presence of primary care data.ResultsThere were 471 events of incident POAG over 464 117 580 person‐years and a mean follow‐up of 12.6 years [Correction added on 18 December 2024, after first online publication: in the “Results” section of the Abstract, the events of incident POAG have been corrected from 647 to 471]. At baseline (time = 0), each one unit increase in BMI was associated with a 9% lower hazard of incident glaucoma (HR 0.91, CI 0.86–0.97, p = 0.0066). Further, compared to a normal BMI range of 18.5–24 kg/m2, a BMI ≥30 kg/m2 was associated with a 65% relative hazard reduction (HR 0.35, CI 0.16–0.80, p = 0.012). There was no significant interaction between BMI and metabolic syndrome or metabolic health (all p > 0.05).ConclusionThe effect of BMI on the risk of incident POAG varied with time. Higher BMI was associated with a decreased risk of incident POAG in this large prospective cohort. There was no significant association with systemic metabolic health.
Effectiveness of Damoctocog Alfa Pegol to Treat Patients With Hemophilia A Enrolled in the ATHNdataset
Authors: Chandler Martin , Moulton Thomas , Charafi Lena , Charlet Jessica , Recht Michael 
Published: November 2024

ABSTRACTObjectivesHealth information for 17 109 people living with hemophilia A (PLwHA) is contained within the ATHNdataset. We aimed to evaluate the real‐world effectiveness of damoctocog alfa pegol (BAY 94‐9027, Jivi®) for hemophilia A.MethodsThe ATHNdataset was queried for PLwHA receiving damoctocog alfa pegol between January 1, 2010 and April 30, 2022. Data captured via patient charts were analyzed.ResultsAt data cutoff, 205 PLwHA were treated with damoctocog alfa pegol: 150 (73.2%) severe (1 female [0.5%]) and 55 (26.8%) mild/moderate (3 [1.5%] female). In total, 32/205 (25.9%) PLwHA received on‐demand treatment; 172 (83.9%) received prophylaxis—161 (93.6%) continuous prophylaxis. Documented bleed rates were available for 187 (91.2%) PLwHA, including those on prophylaxis and on‐demand regimens, with 150 (80.2%) treated for > 12 months. Overall annualized bleeding rates and proportion of PLwHA with zero bleeds, receiving prophylaxis during the observation period, were mean (SD) 0.26 (1.03) and 138/157 (87.9%), respectively. No new or recurring inhibitors were reported.ConclusionA low number of bleeds were observed with damoctocog alfa pegol in the real world in both male and female PLwHA. Data should be interpreted with caution owing to limitations of real‐world studies and insubstantial data for female PLwHA.
Automatic responsiveness testing in epilepsy with wearable technology: The ARTiE Watch
Authors: Wheeler Lydia , Kremen Vaclav , Mersereau Cole , Ornelas Guillermo , Yadav Taruna , Cormier Devon , Derry Allyson , Duque Lopez Andrea , McQuown Kevin , Sladky Vladimir , Benjamin Christopher , Giacino Joseph , Worrell Gregory , Blumenfeld Hal ,   START Project Collaborative Team
Published: November 2024

AbstractObjectiveAn accurate evaluation of behavioral responsiveness during and after seizures in people with epilepsy is critical for diagnosis and management. Current methods for assessing behavioral responsiveness are characterized by substantial variation, subjectivity, and limited reliability and reproducibility in ambulatory and epilepsy monitoring unit settings. In this study, we aimed to develop and implement a novel mobile platform for deployment of automated responsiveness testing in epilepsy—the ARTiE Watch—to facilitate standardized, objective assessments of behavioral responsiveness during and after seizures.MethodsWe prospectively recruited patients admitted to the epilepsy monitoring units for diagnostic evaluation and long‐term video‐electroencephalographic monitoring at Mayo Clinic and Yale New Haven Hospital. Participants wore the ARTiE Watch, a smartwatch paired with custom smartphone software integrated with cloud infrastructure allowing for remote activation of standardized assessment on the participants' smartwatches. The assessment consisted of 18 command prompts that test behavioral responsiveness across motor, language, and memory domains. Upon visually identifying an electrographic seizure during EMU monitoring, the BrainRISE platform was used to deploy the ARTiE Watch behavioral testing sequence. Responsiveness scoring was conducted on smartwatch files.ResultsEighteen of 56 participants had a total of 39 electrographic seizures assessed with the ARTiE Watch. The 18 subjects with ARTiE Watch‐tested seizures had a total of 67 baseline (interictal) ARTiE Watch tests collected for analysis. The analysis showed distinct ARTiE Watch behavioral responsiveness phenotypes: (1) decreased responsiveness across all ARTiE Watch commands during seizure (ictal–postictal) periods compared (to baseline (p < .0001), (2) decreased responsiveness in bilateral tonic–clonic seizures compared to baseline (p < .0001) and compared to focal seizures (p < .0001), and (3) decreased responsiveness during focal impaired awareness seizures compared to baseline (p < .0001) and compared to focal aware seizures (p < .001).SignificanceARTiE Watch behavioral testing deployed utilizing a mobile cloud‐based platform is feasible and can provide standardized, objective behavioral responsiveness assessments during seizures.
WONOEP appraisal: Targeted therapy development for early onset epilepsies
Authors: Casillas‐Espinosa Pablo M. , Wong Jennifer C. , Grabon Wanda , Gonzalez‐Ramos Ana , Mantegazza Massimo , Yilmaz Nihan Carcak , Patel Manisha , Staley Kevin , Sankar Raman , O'Brien Terence J. , Akman Özlem , Balagura Ganna , Numis Adam L. , Noebels Jeffrey L. , Baulac Stéphanie , Auvin Stéphane , Henshall David C. , Galanopoulou Aristea S. 
Published: November 2024

AbstractThe early onset epilepsies encompass a heterogeneous group of disorders, some of which result in drug‐resistant seizures, developmental delay, psychiatric comorbidities, and sudden death. Advancement in the widespread use of targeted gene panels as well as genome and exome sequencing has facilitated the identification of different causative genes in a subset of these patients. The ability to recognize the genetic basis of early onset epilepsies continues to improve, with de novo coding variants accounting for most of the genetic etiologies identified. Although current disease‐specific and disease‐modifying therapies remain limited, novel precision medicine approaches, such as small molecules, cell therapy, and other forms of genetic therapies for early onset epilepsies, have created excitement among researchers, clinicians, and caregivers. Here, we summarize the main findings of presentations and discussions on novel therapeutic strategies for targeted treatment of early onset epilepsies that occurred during the Workshop on Neurobiology of Epilepsy (WONOEP XVI, Talloires, France, July 2022). The presentations discussed the use of chloride transporter inhibitors for neonatal seizures, targeting orexinergic signaling for childhood absence epilepsy, targeting energy metabolism in Dravet syndrome, and the role of cannabinoid receptor type 2, reversible acetylcholinesterase inhibitors, cell therapies, and RNA‐based therapies in early life epilepsies.
SNX17 Regulates Antigen Internalisation and Phagosomal Maturation by Dendritic Cells
Authors: Dinamarca Sofía , Croce Cristina , Salvioni Anna , Garrido Facundo , Fidalgo Sandra Estrada , Bigliani Gonzalo , Mayorga Luis S. , Blanchard Nicolas , Cebrian Ignacio 
Published: November 2024

ABSTRACTAntigen cross‐presentation is the process whereby small peptides derived from exogenous antigens are attached to MHC‐I molecules triggering CD8+ T lymphocyte activation. The endocytic route of dendritic cells (DCs) is highly specialised for cross‐presentation to initiate cytotoxic immune responses against numerous intracellular pathogens and tumours. In this study, we identify the endosomal protein sorting nexin (SNX) 17 as a key regulator of antigen internalisation and cross‐presentation by DCs. SNX17 expression in DCs guarantees optimal cross‐presentation of soluble, particulate, and Toxoplasma gondii‐associated antigens. The silencing of SNX17 expression in DCs significantly affected the internalisation of exogenous antigens by fluid‐phase endocytosis, phagocytosis, and more strikingly, T. gondii invasion. We show that SNX17 controls proper integrin recycling, actin cytoskeleton organisation, and phagosomal maturation. Altogether, our findings provide compelling evidence that SNX17 plays a central role in the modulation of the DC endocytic network, which is essential for competent antigen cross‐presentation.
Comparing remote and hand‐held video observation methods for quantifying a cleaning mutualism
Authors: Cryan Daniel M. , Freeze Jesse , Osenberg Craig W. 
Published: November 2024

AbstractField studies of cleaning mutualisms use a variety of methods to quantify behavioral dynamics. Studies in marine systems typically utilize data recorded by human observers on scuba or snorkel or via remote underwater video. The effects of these different methods on cleaner–client behaviors have not been rigorously assessed. We quantified cleaner–client interactions at 13 bluestreak cleaner wrasse (Labroides dimidiatus) cleaning stations in Moorea, French Polynesia using hand‐held and remote videos. We found that cleaning, cheating, and client posing rates, cleaning duration, and client species richness were all greater in the remote than in the hand‐held videos, suggesting that human presence disrupts cleaning interactions by inducing antipredator responses among clients. Some metrics, such as the ratio of cleaner chasing to cleaning behavior and the cleaners' benthic feeding rate, were higher for the hand‐held than the remote videos, possibly due to limited access of cleaners to clients in the presence of humans. Other metrics, such as cleaner and client chasing rates, the ratio of cleaning to cheating behaviors, and the duration of cleaner chases, did not differ between video types. Finally, piscivorous clients were far more abundant in the remote than the hand‐held videos, suggesting that piscivores are particularly sensitive to human presence, likely because they are targeted by fishers. Overall, our study suggests that human presence can bias studies of cleaning behavior and cleaner–client interactions, and that remote cameras should be used to conduct behavioral studies. These potential biases should be considered when interpreting existing behavioral data.
New bass on the block: Trophic interactions among invasive largemouth bass Micropterus salmoides and local sportfish
Authors: Culberson Abigale E. , Nakamoto Bobby , Lento Jennifer , Curry R. Allen , Harrison Philip M. 
Published: November 2024

AbstractNovel introductions of largemouth bass, Micropterus salmoides, often cause negative impacts on endemic populations of prey fishes and interspecific competitors. Although many studies have investigated trophic interactions between M. salmoides and smallmouth bass, Micropterus dolomieu, few have included chain pickerel, Esox niger, as a competitor despite similarities in their habitat use. We used stable isotope analysis to investigate the trophic ecology of a recently introduced population of M. salmoides in the Wolastoq|Saint John River. Specifically, we measured carbon (δ13C) and nitrogen (δ15N) isotopes to describe isotopic niches and infer resource use of introduced M. salmoides, M. dolomieu, E. niger, and native yellow perch, Perca flavescens, at various life stages. Our results showed that isotopic niche overlap occurred between M. salmoides and other study species, indicative of resource competition. However, resource use plasticity, as demonstrated by a wide variety of resources (marine, terrestrial, littoral, and pelagic) used by all study species, could potentially reduce interspecific competition. Our findings indicate that competition is highest between adult M. salmoides and E. niger, but the presence of a seasonal marine resource can provide important contributions to diets and potentially reduce competition. Further research should focus on monitoring of long‐term trends to identify the dynamics of all study species as M. salmoides populations become further established and dispersed.
Comparative efficacy of Helicobacter pylori eradication therapy between tegoprazan‐based concomitant and bismuth quadruple therapies: A real‐world evidence
Authors: Jung Yoon Suk , Jung Byung Wook , Park Chan Hyuk 
Published: November 2024

AbstractBackground and AimTegoprazan, a potassium‐competitive acid blocker, can be used as a substitute for proton pump inhibitors in Helicobacter pylori eradication therapy; some studies have reported improved efficacy. In Korea, where clarithromycin resistance rates are high, we aimed to compare the efficacies of tegoprazan‐based concomitant and bismuth quadruple therapies.MethodsWe retrospectively analyzed data from patients with H. pylori infection who received either 10‐day tegoprazan‐based concomitant therapy or 14‐day tegoprazan‐based bismuth quadruple therapy as first‐line treatment. The primary outcome was H. pylori eradication rate, with secondary outcomes including adverse events and insufficient medication rates.ResultsAmong the 1082 patients included in the study, 620 and 462 were treated with tegoprazan‐based concomitant and bismuth quadruple therapies, respectively. Intention‐to‐treat analysis demonstrated no difference in eradication rates between the tegoprazan‐based concomitant and bismuth quadruple therapy groups (74.7% [95% confidence interval—CI, 71.1–78.0%] vs 74.7% [95% CI, 70.6–78.5%], P = 0.999). Per‐protocol analysis also showed similar eradication rates between the two groups (88.0% [95% CI, 85.0–90.6%] vs 89.7% [95% CI, 86.3–92.5%], P = 0.424). The overall adverse event rates (49.6% vs 39.2%, P = 0.001) and insufficient medication rates (4.8% vs 2.4%, P = 0.036) were higher in the bismuth quadruple therapy group than in the concomitant therapy group.ConclusionsThe eradication rates of tegoprazan‐based 10‐day concomitant therapy and 14‐day bismuth quadruple therapy were comparable. However, because of its shorter treatment duration, better medical adherence, and lower incidence of adverse events, tegoprazan‐based concomitant therapy may be preferable in regions with high rates of clarithromycin and metronidazole resistance.
Daily association between parent‐adolescent emotion contagion: The role of parent‐adolescent connectedness
Authors: Chiang Shou‐Chun 
Published: November 2024

AbstractEmotion contagion between parents and adolescents is crucial for understanding adolescents' emotional experiences. However, little is known about how emotion contagion unfolds in daily life and the unique contributions of parent‐adolescent relationships. This study examines the associations between parent and adolescent positive and negative emotions, and the moderating role of daily parent‐adolescent connectedness. Participants were 191 Taiwanese adolescents (Mage = 12.93; SDage = 0.75; 53% female) and their parents who completed 10‐day diary reports of emotions and parent‐adolescent connectedness. Results indicate that higher daily parent negative emotions were associated with more adolescent negative emotions, and higher average parent negative emotions were associated with greater average negative emotions and fewer positive emotions in adolescents. Similar bidirectional effects were also found in adolescent‐to‐parent emotion contagion. Moreover, on days when connectedness was high, parent negative emotions were not associated with adolescent negative emotions but were related to increased positive emotions. Parent positive emotions were related to more positive emotions and fewer negative emotions when connectedness was low. The findings provide important insights into daily parent‐adolescent emotion contagion and highlight parent‐adolescent connectedness as a modifying factor in shaping dyadic emotional processes.