bluuebunny/crossref_metadata_2025_split huggingface dataset:
USING LEXICAL FEATURES TO INVESTIGATE SECOND LANGUAGE LEXICAL DECISION PERFORMANCE
Authors: Berger Cynthia , Crossley Scott , Skalicky Stephen 
Published: April 2019

AbstractA large dataset of word recognition behavior from nonnative speakers (NNS) of English was collected using an online crowdsourced lexical decision task. Lexical features were used to predict NNS lexical decision latencies and accuracies. Predictors of NNS latencies and accuracy included contextual diversity, age of acquisition, and contextual distinctiveness, while length moderated the impact of contextual diversity and neighborhood size on accuracy. Results have implications for second language word recognition and demonstrate that NNS behavioral data collected through large crowdsourcing projects can afford a rich source for SLA research.
Use of Shock Index to Identify Mild Hemorrhage: An Observational Study in Military Blood Donors
Authors: Pasquier Pierre , Duron Sandrine , Pouget Thomas , Carbonnel Anne-Charlotte , Boutonnet Mathieu , Malgras Brice , Barbier Olivier , de Saint Maurice Guillaume , Sailliol Anne , Ausset Sylvain , Martinaud Christophe 
Published: April 2019

AbstractIntroduction:Hemorrhage is the leading cause of preventable death in combat, although early recognition of hemorrhage is still challenging on the battlefield.Hypothesis/Problem:The objective of this study was to describe the shock index (SI) in a healthy military population, and to measure its variation during a controlled blood loss, simulated by blood donation.Methods:A prospective observational study that enrolled military subjects, volunteers for blood donation, was conducted. Demographic and clinical information, concerning both the patient and the blood collection, were recorded. Baseline vital signs were measured, before and after donation, in a 45° supine position. Statistical analysis was performed after calculation of SI.Results:A total of 483 participants were included in the study. The mean blood donation volume was 473mL (SD = 44mL). The median pre- and post-blood donation SI were significantly different: 0.54 (IQR = 0.48-0.63) and 0.57 (IQR = 0.49-0.66), respectively (P = .002). Changes in pre-/post-donation blood pressure (BP) and heart rate (HR) also reached statistical difference but represented a clinically poor relevance. The multivariate analysis showed no significant associations between SI variations and age, sex, body mass index (BMI), sport activities, blood donation volume, and enteral volume replacement (EVR).Conclusion:In this model of mild hemorrhage, SI exhibited significant variations but failed to reach clinical relevance. Further studies are needed to prove the benefit of SI calculation as a possible parameter for early recognition of hemorrhage in combat casualties at the point of injury.Pasquier P, Duron S, Pouget T, Carbonnel AC, Boutonnet M, Malgras B, Barbier O, de Saint Maurice G, Sailliol A, Ausset S, Martinaud C. Use of shock index to identify mild hemorrhage: an observational study in military blood donors. Prehosp Disaster Med. 2019;34(3):303–307.
A new approach for textual feature selection based on N-composite isolated labels
Authors: Elloumi Samir 
Published: April 2019

AbstractTextual Feature Selection (TFS) aims to extract relevant parts or segments from text as being the most relevant ones w.r.t. the information it expresses. The selected features are useful for automatic indexing, summarization, document categorization, knowledge discovery, so on. Regarding the huge amount of electronic textual data daily published, many challenges related to the semantic aspect as well as the processing efficiency are addressed. In this paper, we propose a new approach for TFS based on Formal Concept Analysis background. Mainly, we propose to extract textual features by exploring the regularities in a formal context where isolated points exist. We introduce the notion ofN-composite isolated points as a set ofNwords to be considered as a unique textual feature. We show that a reduced value ofN(between 1 and 3) allows extracting significant textual features compared with existing approaches even for non-completely covering an initial formal context.
Poor Sleep Quality and Compromised Visual Working Memory Capacity
Authors: Xie Weizhen , Berry Anne , Lustig Cindy , Deldin Patricia , Zhang Weiwei 
Published: April 2019

AbstractObjectives:Reduction in the amount of information (storage capacity) retained in working memory (WM) has been associated with sleep loss. The present study examined whether reduced WM capacity is also related to poor everyday sleep quality and, more importantly, whether the effects of sleep quality could be dissociated from the effects of depressed mood and age on WM.Methods:In two studies, WM was assessed using a short-term recall task, producing behavioral measures for both the amount of retained WM information (capacity) and how precise the retained WM representations were (precision). Self-report measures of sleep quality and depressed mood were obtained using questionnaires.Results:In a sample of college students, Study 1 found that poor sleep quality and depressed mood could independently predict reduced WM capacity, but not WM precision. Study 2 generalized these sleep- and mood-related WM capacity effects to a community sample (aged 21–77 years) and further showed that age was associated with reduced WM precision.Conclusions:Together, these findings demonstrate dissociable effects of three health-related factors (sleep, mood, and age) on WM representations and highlighte the importance of assessing different aspects of WM representations (e.g., capacity and precision) in future neuropsychological research.
‘Courses for Horses’: designing, adapting and implementing self practice/self-reflection programmes
Authors: Freeston Mark H. , Thwaites Richard , Bennett-Levy James 
Published: April 2019

AbstractSelf-Practice/Self-Reflection (SP/SR) has been proposed both as an adjunct to therapy training programmes, and also as a means for therapist development among experienced therapists. Research suggests it develops aspects of knowledge and skill that may not be addressed through other training methods. With increasing interest in SP/SR, a growing evidence base regarding both participant benefits and potential risks from SP/SR, and the development of SP/SR programmes across a range of therapeutic modalities, we argue it is timely to identify a set of principles that can guide the design, adaptation and implementation of SP/SR programmes. At this stage, there is little empirical evidence to guide trainers wishing to implement SP/SR in different contexts. Accordingly, these principles have been derived from reflection on developing, testing and implementing SP/SR programmes as well as on other training and supervisory experience. The first set of principles detailed in Section 1 draw on various theories of learning and development and frame the processes involved, the next principles speak to the content of SP/SR programmes, and the final principles address structure. Within Section 2, the principles are then considered for their practical implications. In Section 3, the sharing of what are initially private self-reflections is then considered together with some implications for SP/SR programmes, especially when there is assessment involved. We argue that SP/SR will continue to progress with well-designed standard programmes, careful implementation, thoughtful adaptation, ongoing innovation, and especially more evaluation.Key learning aims(1)To understand the principles for designing, adapting and implementing SP/SR programmes that are drawn from theory and from the authors’ experience of developing and implementing SP/SR programmes over the last 20 years.(2)To understand the possible factors that guide the processes, content and structure of SP/SR programmes.(3)To understand how best to maximize effective engagement and learning (and limit harm) when planning or implementing an SP/SR programme.
A Simplified Model for the Baroclinic and Barotropic Ocean Response to Moving Tropical Cyclones: 1. Satellite Observations
Authors: Kudryavtsev Vladimir , Monzikova Anna , Combot Clément , Chapron Bertrand , Reul Nicolas , Quilfen Yves 
Published: April 2019

AbstractChanges of sea surface temperature and height, derived from 20‐day passive microwave and altimeter measurements for three tropical cyclones (TCs), Jimena, Ignacio and Kilo, during the 2015 Pacific hurricane season, sampling different stages of intensification, wind speeds, radii, Coriolis parameter, translation velocities, and ocean stratification conditions, are reported and analyzed. As triggered along the path of moving TCs, very large interior ocean displacements can occur to leave prominent sea surface height (SSH) anomalies in the TC wake. Resulting surface depressions can reach 0.3–0.5 m, depending upon size, translation speed, and ocean stratification conditions. These signatures can be quite persistent, that is, more than few weeks, to possibly be intercepted with satellite altimeters. To interpret sea surface temperature (SST) and SSH anomalies, a semiempirical framework is adopted, based on the heat and momentum conservations laws for the upper wind driven mixed layer. As interpreted, SSH anomalies provide direct estimates to evaluate the upwelling impact, that is, the upwelling amplification on the SST wake. For the reported cases, the influence of the upwelling is found rather moderate, of order 10–40%. More promising, the proposed bottom‐up approach can help document the resulting wind forcing and practical drag coefficient under extreme TC conditions. As found for these three TCs, a marked drag reduction for wind speed higher than 35 m/s is inferred to ensure consistency with the measured SSH and SST anomalies.
The Impact of Mesoscale Gravity Waves on Homogeneous Ice Nucleation in Cirrus Clouds
Authors: Kärcher B. , Jensen E. J. , Lohmann U. 
Published: April 2019

AbstractEffects of a spectrum of mesoscale gravity waves on homogeneous aerosol freezing in midlatitude cirrus are studied by means of parcel model simulations that are driven by random vertical wind speeds constrained by balloon measurements. Stochastic wave forcing with mean updraft speeds of 5–20 cm/s leads to substantial nucleated ice crystal number concentrations (ICNC) of 0.1–1 cm−3 in situations with slow large‐scale cooling, which by itself would generate fewer ice crystals. The stochastic nature of wave‐driven air parcel temperatures enhances ICNC even further, but the times required to reach freezing conditions unsupported by large‐scale cooling may vary widely. In the presence of wave forcing, ice crystals with low ICNC (<1–10 L−1) are also generated by homogeneous freezing, albeit only rarely. Comparisons with aircraft measurements suggest significant influences of heterogeneous ice‐nucleating particles and ice crystal sedimentation on ICNC, but quantifying their individual contributions remains elusive.
Long‐Term Support of an Active Subglacial Hydrologic System in Southeast Greenland by Firn Aquifers
Authors: Poinar Kristin , Dow Christine F. , Andrews Lauren C. 
Published: April 2019

AbstractThe state of the subglacial hydrologic system, which can modify ice motion, is sensitive to the volume and rate of meltwater reaching it. Bare‐ice regions rapidly transport meltwater to the bed via moulins, while in certain accumulation zone regions, meltwater first flows through firn aquifers, which can introduce a substantial delay. We use a subglacial hydrological model forced with idealized meltwater input scenarios to test the effect of this delay on subglacial hydrology. We find that addition of firn‐aquifer water to the subglacial system elevates the inland subglacial water pressure while reducing water pressure and enhancing subglacial channelization near the terminus. This effect dampens seasonal variations in subglacial water pressure and may explain regionally anomalous ice velocity patterns observed in Southeast Greenland. As surface melt rates increase and firn aquifers expand inland, it is crucial to understand how inland drainage of meltwater affects the evolution of the subglacial hydrologic system.
Characterisation of N-terminal pro-brain natriuretic peptide in dialysis patients and its reduced prognostic significance in the elderly
Authors: Sato Yuji , Ishizaki Yuri , Aso Kumiko , Minakwa Akihiro , Toida Tatsunori , Nishizono Ryuzoh , Kikuchi Masao , Inagaki Hiroko , Fujimoto Shouichi 
Published: April 2019

AbstractCharacterisation of N-terminal pro-brain natriuretic peptide (NT-proBNP) in chronic haemodialysis patients and its prognostic significance in age stratification have not been addressed. A prospective cohort study with cross-sectional analyses at baseline was performed. Outcomes were all-cause mortality, non-malignancy-related mortality, and cardiovascular disease (CVD)-related mortality. NT-proBNP was significantly higher in elderly, female, and low dry weight patients. Study patients were divided into two groups: Group-O (≥75 years) and Group-Y (<75 years). The 7-year follow-up receiver operating curve analysis showed that NT-proBNP significantly predicted all outcomes. All-cause mortality cut-off points were significantly different among the groups (total cohort, 5375 pg/mL; Group-Y, 3682 pg/mL; Group-O, 11750 pg/mL). Cox regression analysis showed risks for all outcomes by tertile NT-proBNP significantly higher in the total cohort and Group-Y as adjusted by potential confounders. For all-cause mortality, hazard ratios and 95% confidence intervals (CI) were T2 1.70 (0.89 to 3.25), p = 0.11, T3 2.95 (1.54 to 5.67), p < 0.01 in Group-Y; and T2 1.00 (0.64 to 1.58), p = 1.00; T3 1.50 (0.94 to 2.40), p = 0.09 in Group-O. In conclusion, NT-proBNP was significantly higher in elderly, female, and low dry weight chronic dialysis patients. NT-proBNP was significantly associated with all outcomes. However, this association was reduced in elderly patients.
Glycolic acid attenuates UVB-induced aquaporin-3, matrix metalloproteinase-9 expression, and collagen degradation in keratinocytes and mouse skin
Authors: Tang Sheau-Chung , Tang Lee-Chun , Liu Chin-Hung , Liao Pei-Yun , Lai Ji-Ching , Yang Jen-Hung 
Published: April 2019

Abstract
Ultraviolet-B exposure causes an inflammatory response, photoaged skin, and degradation of extracellular matrix proteins including collagen and elastin. The regulation of these genes was suggested as an important mechanism to attenuate skin aging. Glycolic acid (GA) is commonly present in fruits and recently used to treat dermatological diseases. We reported that GA slows down cell inflammation and aging caused by UVB. Little is known about GA retarding the skin premature senescence or how to impede these events. To investigate the potential of GA to regulate the expression of MMPs and collagen, GA was topically applied onto human keratinocytes and the C57BL/6J mice dorsal skin. In the present study, we demonstrated that GA reduced UVB-induced type-I procollagen expression and secretory collagen levels. GA reverted and dose-dependently increased the level of aquaporin-3 (AQP3), the expression of which was down-regulated by UVB. The UV-induced MMP-9 level and activity were reduced by GA pre-treatment. Concomitantly, GA reverted mitogen-activated protein kinase (MMP-9) activation and inhibited the extracellular signal-regulated kinase activation (p38, pERK) triggered by UVB. The animal model also presented that GA attenuated the wrinkles caused by UVB on the mouse dorsal skin. Finally, GA triggers the transient receptor potential vanilloid-1 (TRPV-1) channel to initiate the anti-photoaging mechanism in keratinocytes. These findings clearly indicated that the mechanisms of GA promote skin protection against UVB-induced photoaging and wrinkle formation. GA might be an important reagent and more widely used to prevent UVB-induced skin aging.
Slc25a36 modulates pluripotency of mouse embryonic stem cells by regulating mitochondrial function and glutathione level
Authors: Xin Yanli , Wang Yanliang , Zhong Liang , Shi Bingbo , Liang Hui , Han Jianyong 
Published: April 2019

Abstract
Mitochondria play a central role in the maintenance of the naive state of embryonic stem cells. Many details of the mechanism remain to be fully elucidated. Solute carrier family 25 member 36 (Slc25a36) might regulate mitochondrial function through transporting pyrimidine nucleotides for mtDNA/RNA synthesis. Its physical role in this process remains unknown; however, Slc25a36 was recently found to be highly expressed in naive mouse embryonic stem cells (mESCs). Here, the function of Slc25a36 was characterized as a maintenance factor of mESCs pluripotency. Slc25a36 deficiency (via knockdown) has been demonstrated to result in mitochondrial dysfunction, which induces the differentiation of mESCs. The expression of key pluripotency markers (Pou5f1, Sox2, Nanog, and Utf1) decreased, while that of key TE genes (Cdx2, Gata3, and Hand1) increased. Cdx2-positive cells emerged in Slc25a36-deficient colonies under trophoblast stem cell culture conditions. As a result of Slc25a36 deficiency, mtDNA of knockdown cells declined, leading to impaired mitochondria with swollen morphology, decreased mitochondrial membrane potential, and low numbers. The key transcription regulators of mitochondrial biogenesis also decreased. These results indicate that mitochondrial dysfunction leads to an inability to support the pluripotency maintenance. Moreover, down-regulated glutathione metabolism and up-regulated focal adhesion reinforced and stabilized the process of differentiation by separately enhancing OCT4 degradation and promoting cell spread. This study improves the understanding of the function of Slc25a36, as well as the relationship of mitochondrial function with naive pluripotency maintenance and stem cell fate decision.
Differential expression and bioinformatics analysis of circRNA in osteosarcoma
Authors: Xi Yizhe , Fowdur Mitra , Liu Yun , Wu Hao , He Maolin , Zhao Jinmin 
Published: April 2019

Abstract
Aim: This research aims to investigate the expression profile of circRNA in osteosarcoma and to identify the underlying pathogenesis core genes of osteosarcoma.
Methods: Illumina HiSeq was used to screen differentially expressed circRNAs between the tumour tissues and paracancerous tissues of three osteosarcoma patients. Bioinformatics analysis was used to analyse their potential functions. Five differentially expressed circRNAs were selected to detect the relative expression level in tumour and paracancerous tissues of ten osteosarcoma patients by real-time PCR. The databases such as DisGeNET and miRWalk were used to collect related genes or miRNAs.
Results: A total of 259 differentially expressed circRNAs were evaluated in patients with osteosarcoma, of which 132 were up-regulated and 127 were down-regulated. Compared with that in paracancerous tissues, circ_32279 and circ_24831 were significantly down-regulated while circ_2137 and circ_20403 were significantly up-regulated in osteosarcoma tissues. The differential expression of circRNA is closely linked to biological processes and molecular functions. The difference in circRNA was mainly linked to the ‘phosphatidylinositol signalling system’ signal pathway and the ‘inositol phosphate metabolism’ signal pathway.
Conclusion: The present study identified a profile of abnormal regulation of circRNA in osteosarcoma. Bioinformatics analysis indicates that the deregulated circRNAs may be related to the occurrence and development of osteosarcoma.
Benefits and Shortcomings of Direct-to-Consumer Hearing Devices: Analysis of Large Secondary Data Generated From Amazon Customer Reviews
Authors: Manchaiah Vinaya , Amlani Amyn M. , Bricker Christina M. , Whitfield Clayton T. , Ratinaud Pierre 
Published: April 2019

Purpose
The current study was aimed at understanding the benefits and shortcomings of direct-to-consumer hearing devices (DCHDs) by analyzing the large text corpus of secondary data generated from Amazon customer reviews.

Method

Secondary data were generated manually by gathering user feedback for 62 different DCHDs (cost range: $9.95–$635) on the
Amazon.com
website, which included 11,258 unique Amazon-verified customer reviews. The data were analyzed using both quantitative and qualitative analyses methods.

Results

The cluster analysis of large data corpus resulted in 7 unique clusters, which were labeled as (a)
Issues related to fit and comfort
(15%), (b)
Friends and family recommendations
(11.8%), (c)
Issues related to sound quality
(11.9%), (d)
Listening and conversation
(16.1%), (e)
Positive customer service
(12.1%), (f)
General usage and customer service
(14.7%), and (g)
Cost and affordability
(17.3%). Exploratory analysis also revealed an association between customer ratings and cost in relation to these clusters (i.e., customer reviews). For example, customer reviews about cheaper DCHDs are related to issues about sound quality, whereas reviews about expensive DCHDs are related to cost and affordability of the device. The qualitative content analysis resulted in 8 main themes, which include (a) intrinsic factors, (b) extrinsic factors, (c) supplemental items, (d) ease of use, (e) interaction with support services, (f) reasons for purchase, (g) experiences, and (h) general information.

Conclusions
The study using the text mining techniques highlights the benefits and shortcomings of DCHDs that are currently available in the U.S. market. Our findings relate well to the published study results of electroacoustic analysis on similar products, which provide clinicians with knowledge related to DCHDs that they can convey to consumers during clinical consultations. The findings may also be of interest to the hearing instrument industry from the perspective of developing products based on user feedback.