bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMANFAATAN INFORMASI BERDASARKAN PORTER’S FIVE FORCES DALAM BISNIS FABRIKASI BAJA UNTUK MENDAPATKAN KEUNGGULAN BERSAING
Authors: Kusuma Kristiawan Hengki , Budiman Januar 
Published: May 2019

Saat ini perusahaan fabrikasi baja telah menyadari pentingnya penggunaan informasi sebagai sebuah tools baru untuk mendapatkan keunggulan bersaing dengan kompetitor. Namun sayangnya penggunaan informasi ini masih diterapkan secara konvensional, yaitu penggunaan informasi yang hanya terbatas pada penggunaan IT, tanpa menyadari sebenarnya penggunaan informasi masih menyimpan banyak potensi besar jika digunakan secara optimal.
Penggunaan Informasi yang “asal pakai” tidak hanya kurang efektif namun juga seringkali menimbulkan permasalahan baru. Hasil penyajian data yang diolah oleh orang IT seringkali tidak sesuai dengan tujuan yang ingin dicapai oleh manajemen perusahaan karena perbedaan penafsiran, adapun hasil pengolahan data seringkali juga dapat menimbulkan kesalahpahaman antar pihak manajemen.
Pada penelitian ini akan dicoba pemanfaatan Informasi dengan menggunakan bantuan Porter’s Five Forces sebagai alat bantu untuk mendapatkan keunggulan bersaing. Akan dijelaskan juga bagaimana cara untuk mengumpulkan informasi apa saja yang ada di dalam business process yang dibutuhkan dalam perusahaan dan bagaimana cara mengolah data ini menjadi keunggulan bersaing bagi perusahaan fabrikasi.

Nowadays, steel fabricator has realized the importance of the use of information as a new tools to gain the competitive advantages with competitors. Unfortunely the use odf the information is still applied in an unconventional manner, the use of information are limited only to IT, without realizing actual use information has a lot of great potential if used optimally.
The “reckless” use of information was not only less effective but also often lead to new problems. The result of data processed by IT’s, usually are not in line with the purpose to be achieved by company management due the differences in the interpretation of the concept, and as for the results of data processing can also cause misunderstanding between management.
On this research will try the utilization of information by using Porter’s Five Forces as the tools to gain the competitive advantages. It will be explained also how to collect all information in business process that required in company and how to process this data to be competitive advantages for steel fabrication company.
Quantitative evaluation of breast density using a dual‐energy technique on a digital breast tomosynthesis system
Authors: Lu Kun‐Mu , Yeh Da‐Ming , Cao Bi‐Hui , Lin Chia‐Yi , Liang Chih‐Yu , Zhou Yu‐Bo , Tsai Chia‐Jung 
Published: May 2019

AbstractPurposeAlthough breast density is considered a strong risk factor of breast cancer, its quantitative assessment is difficult. To investigate a quantitative method of measuring breast density using dual‐energy mammographic imaging with central digital breast tomosynthesis in physically uniform and nonuniform phantoms.Material and methodsThe dual‐energy imaging unit used a tungsten anode and silver filter with 30 kVp for high‐energy images and 20 kVp for low‐energy images. Uniform glandular‐equivalent phantoms were used to calibrate a dual‐energy based decomposition algorithm. The first study used uniform breast phantoms which ranged in thicknesses from 20 to 70 mm, in 10‐mm increments, and which provided 30%, 50%, and 70% of breast density. The second study used uniform phantoms ranging from 10% to 90% of breast density. The third study used non‐uniform phantoms (at an average density of 50%) with a thickness which ranged from 20 to 90 mm, in 10‐mm increments.ResultsThe root mean square error of breast density measurements was 2.64–3.34% for the uniform, variable thickness phantoms, 4.17% for the uniform, variable density phantoms, and 4.49% for the nonuniform, variable thickness phantoms.ConclusionThe dual‐energy technique could be used to measure breast density with a margin of error of < 10% using digital breast tomosynthesis.
Effect of Doping and Excitation Wavelength on Charge Carrier Dynamics in Hematite by Time‐Resolved Microwave and Terahertz Photoconductivity
Authors: Kay Asaf , Fiegenbaum‐Raz Mor , Müller Sönke , Eichberger Rainer , Dotan Hen , van de Krol Roel , Abdi Fatwa F. , Rothschild Avner , Friedrich Dennis , Grave Daniel A. 
Published: May 2019

AbstractThe charge carrier dynamics of epitaxial hematite films is studied by time‐resolved microwave (TRMC) and time‐resolved terahertz conductivity (TRTC). After excitation with above bandgap illumination, the TRTC signal decays within 3 ps, consistent with previous reports of charge carrier localization times in hematite. The TRMC measurements probe charge carrier dynamics at longer timescales, exhibiting biexponential decay with characteristic time constants of ≈20–50 ns and 1–2 μs. From the change in photoconductance, the effective carrier mobility is extracted, defined as the product of the charge carrier mobility and photogeneration yield, of differently doped (undoped, Ti, Sn, Zn) hematite films for excitation wavelengths of 355 and 532 nm. It is shown that, unlike in conventional semiconductors, donor doping of hematite dramatically increases the effective mobility of the photogenerated carriers. Furthermore, it is shown that all hematite films possess higher effective mobility for 355 nm excitation than for 532 nm excitation, although the time dependence of the photoconductance decay, or charge carrier lifetime, remains the same. These results provide an explanation for the wavelength dependent photoelectrochemical behavior of hematite photoelectrodes and suggest that an increase in photogeneration yield or charge carrier mobility is responsible for the improved performance at higher excitation energies.
Selective Electroplating for 3D‐Printed Electronics
Authors: Lazarus Nathan , Bedair Sarah S. , Hawasli Sami H. , Kim Myung Jun , Wiley Benjamin J. , Smith Gabriel L. 
Published: May 2019

AbstractCreating 3D‐printed parts with embedded circuitry is the next frontier in additive manufacturing, but printing of conductors with performance comparable to bulk metals such as copper is a difficult challenge. A hybrid process based on 3D printing followed by electroplating on highly conductive thermoplastic filament is used to manufacture 3D circuit boards and electronic packaging. Dual extruder heads on a standard fused filament fabrication printer are used to selectively define regions for electroplating, allowing distinct traces and multiple materials to be patterned in the same 3D‐printed parts. Using this approach, a 3D‐printed surface‐mount package and a 555 timer oscillator circuit are demonstrated, including soldering of components onto the electroplated copper surface.
Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia
Authors: McGann Patrick T. , Niss Omar , Dong Min , Marahatta Anu , Howard Thad A. , Mizuno Tomoyuki , Lane Adam , Kalfa Theodosia A. , Malik Punam , Quinn Charles T. , Ware Russell E. , Vinks Alexander A. 
Published: May 2019

AbstractHydroxyurea is FDA‐approved and now increasingly used for children with sickle cell anemia (SCA), but dosing strategies, pharmacokinetic (PK) profiles, and treatment responses for individual patients are highly variable. Typical weight‐based dosing with step‐wise escalation to maximum tolerated dose (MTD) leads to predictable laboratory and clinical benefits, but often takes 6 to 12 months to achieve. The Therapeutic Response Evaluation and Adherence Trial (TREAT, NCT02286154) was a single‐center study designed to prospectively validate a novel personalized PK‐guided hydroxyurea dosing strategy with a primary endpoint of time to MTD. Enrolled participants received a single oral 20 mg/kg dose of hydroxyurea, followed by a sparse PK sampling approach with three samples collected over three hours. Analysis of individual PK data into a population PK model generated a starting dose that targets the MTD. The TREAT cohort (n = 50) was young, starting hydroxyurea at a median age of 11 months (IQR 9‐26 months), and PK‐guided starting doses were high (27.7 ± 4.9 mg/kg/d). Time to MTD was 4.8 months (IQR 3.3‐9.3), significantly shorter than comparison studies (p < 0.0001), thus meeting the primary endpoint. More remarkably, the laboratory response for participants starting with a PK‐guided dose was quite robust, achieving higher hemoglobin (10.1 ± 1.3 g/dL) and HbF (33.3 ± 9.1%) levels than traditional dosing. Though higher than traditional dosing, PK‐guided doses were safe without excess hematologic toxicities. Our data suggest early initiation of hydroxyurea, using a personalized dosing strategy for children with SCA, provides laboratory and clinical response beyond what has been seen historically, with traditional weight‐based dosing.
Generalized Darboux Transformations, Rogue Waves, and Modulation Instability for the Coherently Coupled Nonlinear Schrödinger Equations in Nonlinear Optics
Authors: Chen Su‐Su , Tian Bo , Sun Yan , Zhang Chen‐Rong 
Published: May 2019

AbstractNonlinear optics plays a central role in the advancement of optical science and laser‐based technologies. The second‐order rogue‐wave solutions and modulation instability for the coherently coupled nonlinear Schrödinger equations with the positive coherent coupling in nonlinear optics are reported in this paper. Generalized Darboux transformations for such coupled equations are derived, with which the second‐order rational solutions for the purpose of modelling the rogue waves are obtained. With respect to the slowly‐varying complex amplitudes of two interacting optical modes, it is observed that 1) number of valleys of the second‐order rogue waves increases and peak value of the second‐order rogue wave decreases first and then increases; 2) single‐hump second‐order rogue wave turns into the double‐hump second‐order rogue wave; 3) single‐hump bright second‐order rogue wave turns into the dark second‐order rogue wave and finally becomes the three‐hump bright second‐order rogue wave. Meanwhile, baseband modulation instability through the linear stability analysis is seen.
Method for Finding the Exact Effective Hamiltonian of Time‐Driven Quantum Systems
Authors: Sandoval‐Santana Juan Carlos , Ibarra‐Sierra Victor Guadalupe , Cardoso José Luis , Kunold Alejandro , Roman‐Taboada Pedro , Naumis Gerardo 
Published: May 2019

AbstractTime‐driven quantum systems are important in many different fields of physics as cold atoms, solid state, optics, etc. Many of their properties are encoded in the time evolution operator or the effective Hamiltonian. Finding these operators usually requires very complex calculations that often involve some approximations. To perform this task, a systematic scheme that can be cast in the form of a symbolic computational algorithm is presented. It is suitable for periodic and non‐periodic potentials and, for convoluted systems, can also be adapted to yield numerical solutions. The method exploits the structure of the associated Lie group and a decomposition of the evolution operator on each group generator. To illustrate the use of the method, five examples are provided: harmonic oscillator with time‐dependent frequency (Paul trap), modulated optical lattice, time‐driven quantum oscillator, a step‐wise driving of a free particle, and the non‐periodic Caldirola‐Kanai Hamiltonian. To the extent of the authors' knowledge, whereas the exact form of Paul trap's evolution operator is well known, its effective Hamiltonian was until now unknown. The remaining four examples accurately reproduce previous results.
Integrating local ecological knowledge, citizen science and long‐term historical data for endangered species conservation: Additional records of angel sharks (Chondrichthyes: Squatinidae) in the Mediterranean Sea
Authors: Giovos Ioannis , Stoilas Vasilis‐Orestis , Al‐Mabruk Sara AA , Doumpas Nikolaos , Marakis Philippos , Maximiadi Mary , Moutopoulos Dimitrios , Kleitou Periklis , Keramidas Ioannis , Tiralongo Francesco , de Maddalena Alessandro 
Published: May 2019

Abstract

All three species of angel sharks (genus Squatina) inhabiting the Mediterranean Sea are listed as Critically Endangered in the International Union for Conservation of Nature Red List of Threatened Species due to overexploitation.
New records from Cyprus, Greece, Italy and Libya were collected from citizen‐scientists and integrated with local knowledge obtained using structured interviews in the four countries.
Observations and reports, together with an analysis of the reconstructed fisheries data, resulted in the identification of areas of interest, a review of the illegal trade of the species and a debate about the credibility of fisheries data for assessing threatened and/or protected species.
Unconventional sources of information, such as social media, were identified as important tools for monitoring rare and endangered marine wildlife.
This work will contribute to promoting international cooperation for advancing angel shark conservation in line with the Eastern Atlantic and Mediterranean Angel Shark Conservation Strategy.
Inhibition of EZH2 Ameliorates Lupus‐Like Disease in MRL/lpr Mice
Authors: Rohraff Dallas M. , He Ye , Farkash Evan A. , Schonfeld Mark , Tsou Pei‐Suen , Sawalha Amr H. 
Published: May 2019

ObjectiveWe previously identified a role for EZH2, a transcriptional regulator in inducing proinflammatory epigenetic changes in lupus CD4+ T cells. This study was undertaken to investigate whether inhibiting EZH2 ameliorates lupus‐like disease in MRL/lpr mice.MethodsEZH2 expression levels in multiple cell types in lupus patients were evaluated using flow cytometry and messenger RNA expression data. Inhibition of EZH2 in MRL/lpr mice was achieved by intraperitoneal 3′‐deazaneplanocin (DZNep) administration using a preventative and a therapeutic treatment model. Effects of DZNep on animal survival, anti–double‐stranded DNA (anti‐dsDNA) antibody production, proteinuria, renal histopathology, cytokine production, and T and B cell numbers and percentages were assessed.ResultsEZH2 expression levels were increased in whole blood, neutrophils, monocytes, B cells, and CD4+ T cells in lupus patients. In MRL/lpr mice, inhibition of EZH2 by DZNep was confirmed by significant reduction of EZH2 and H3K27me3 in splenocytes. Inhibiting EZH2 with DZNep treatment before or after disease onset improved survival and significantly reduced anti‐dsDNA antibody production. DZNep‐treated mice displayed a significant reduction in renal involvement, splenomegaly, and lymphadenopathy. Lymphoproliferation and numbers of double‐negative T cells were significantly reduced in DZNep‐treated mice. Concentrations of circulating cytokines and chemokines, including tumor necrosis factor, interferon‐γ, CCL2, RANTES/CCL5, interleukin‐10 (IL‐10), keratinocyte‐derived chemokine/CXCL1, IL‐12, IL‐12p40, and CCL4/macrophage inflammatory protein 1β, were decreased in DZNep‐treated mice.ConclusionEZH2 is up‐regulated in multiple cell types in lupus patients. Therapeutic inhibition of EZH2 abrogates lupus‐like disease in MRL/lpr mice, suggesting that EZH2 inhibitors may be repurposed as a novel therapeutic option for lupus patients.
A Link Between Plasma Microbial Translocation, Microbiome, and Autoantibody Development in First‐Degree Relatives of Systemic Lupus Erythematosus Patients
Authors: Ogunrinde Elizabeth , Zhou Zejun , Luo Zhenwu , Alekseyenko Alexander , Li Quan‐Zhen , Macedo Danielle , Kamen Diane L. , Oates Jim C. , Gilkeson Gary S. , Jiang Wei 
Published: May 2019

ObjectiveSystemic lupus erythematosus (SLE) is characterized by the production of antibodies against self antigens. However, the events underlying autoantibody formation in SLE remain unclear. This study was undertaken to investigate the role of plasma autoantibody levels, microbial translocation, and the microbiome in SLE.MethodsPlasma samples from 2 cohorts, one with 18 unrelated healthy controls and 18 first‐degree relatives and the other with 19 healthy controls and 21 SLE patients, were assessed for autoantibody levels by autoantigen microarray analysis, measurement of lipopolysaccharide (LPS) levels by Limulus amebocyte assay, and determination of microbiome composition by microbial 16S ribosomal DNA sequencing.ResultsFirst‐degree relatives and SLE patients exhibited increased plasma autoantibody levels compared to their control groups. Parents and children of lupus patients exhibited elevated plasma LPS levels compared to controls (P = 0.02). Plasma LPS levels positively correlated with plasma anti–double‐stranded DNA IgG levels in first‐degree relatives (r = 0.51, P = 0.03), but not in SLE patients. Circulating microbiome analysis revealed that first‐degree relatives had significantly reduced microbiome diversity compared to their controls (observed species, P = 0.004; Chao1 index, P = 0.005), but this reduction was not observed in SLE patients. The majority of bacteria that were differentially abundant between unrelated healthy controls and first‐degree relatives were in the Firmicutes phylum, while differences in bacteria from several phyla were identified between healthy controls and SLE patients. Bacteria in the Paenibacillus genus were the only overlapping differentially abundant bacteria in both cohorts, and were reduced in first‐degree relatives (adjusted P [Padj] = 2.13 × 10−12) and SLE patients (Padj = 0.008) but elevated in controls.ConclusionsThese results indicate a possible role of plasma microbial translocation and microbiome composition in influencing autoantibody development in SLE.
The free‐weight matrix approach to event‐driven output H∞ control of networked control systems
Authors: Shen Binbin , Guo Jing , Sun Liankun 
Published: May 2019

AbstractThis paper puts forward a new free‐weight matrix method used to analyse Network control systems (NCSs) with the H∞ performance index level based on event‐driven control. Firstly, design a relative triggering mechanism contain the measured output for a linear system with external disturbances. Secondly, in order to reduce the conservativeness an appropriate Lyapunov‐Krasovskii function is constructed. For the integral term generated after the above functional derivation, the free‐weight matrix inequality is selected for scaling. Finally,the sufficient condition that the closed‐loop system represented by the linear matrix inequality (LMI) satisfies the H∞ performance index and the solution of the controller are obtained.The validity of the scheme is confirmed by a given numerical case.
Vom 3‐D‐Laserscan zum BIM‐Modell
Authors: Mischo Hendrik , Seifried Jörg , Thiele Klaus , Schanzenbach Stephan , Grassl Martin 
Published: May 2019

AbstractIn den kommenden Dekaden erfordern die deutschen Brückenbauwerke eine erhöhte Aufmerksamkeit, da für einen großen Anteil des Bestands die vorgesehene Lebensdauer erreicht ist. Einige dieser Bauwerke haben neben ihrer Bedeutung für die Infrastruktur einen hohen baukulturellen Wert und fordern daher große Sorgfalt seitens der Bauwerkserhaltung.Für die anstehenden Aufgaben im Bereich bestehender Brückenbauwerke wurde anhand eines Beispiels die Anwendung der Planungsmethodik BIM auf ihre derzeitigen Möglichkeiten untersucht. Im Vordergrund der Untersuchung stehen die Erfassung der Geometrie einer bestehenden Brücke mit einem 3‐D‐Laserscan, die Verarbeitung der resultierenden Punktwolke zu einem virtuellen Bauwerksmodell (BIM‐Modell) und schließlich die Ableitung eines statischen Modells aus dem BIM‐Modell.
How do counsellors having menopausal symptoms experience their client work: An interpretative phenomenological analysis
Authors: Bodza Carol , Morrey Tara , Hogan Kevin F. 
Published: May 2019

AbstractAimThe aim of this study was to discover whether menopausal symptoms have implications for counsellors in their therapeutic work.MethodSemi‐structured interviews were conducted with three counsellors who have experienced menopausal symptoms. The menopause is a unique experience for the individual. Interpretative phenomenological analysis therefore allowed for a detailed exploration of the participants' experiences.FindingsFour superordinate themes were identified: transitioning personal and professional identity during menopause; limited dialogue about the menopause; ethical dilemmas of practising as a counsellor when menopausal; and the influence of menopausal symptoms during client work. The findings demonstrated that participants each had very personal and individual experiences of the menopause. A lack of knowledge and understanding of the menopause and limited dialogue within society to discuss symptoms was also reflected in the counselling profession. The capacity to continue working therapeutically presented potential ethical dilemmas which were affected by menopausal symptoms.ConclusionCounsellors' experiences of menopausal symptoms may create challenges in their therapeutic work, ranging from a mild distraction, a disconnection with a client, to having to cease engaging with client work. Implications for therapeutic practice are discussed.
Durable complete response in a patient with metastatic left‐sided colon cancer treated with 5‐fluorouracil, folinic acid, and irinotecan (FOLFIRI) and panitumumab: A case report
Authors: Kim Esther , Bay Graham H. , Kim Christina A. 
Published: May 2019

AbstractThere are rare patients with metastatic colon cancer who experience dramatic and durable responses. Primary tumor location is a prognostic and potentially predictive factor and should be taken into consideration when deciding on the optimal first‐line therapy to be used in combination with chemotherapy.
The Origins of the Stereoselectivity and Enantioswitch in the Rare‐Earth‐Catalyzed Michael Addition: A Computational Study
Authors: Miyazaki Aya , Hatanaka Miho 
Published: May 2019

AbstractThe general strategy for forming an opposite enantiomeric product from an asymmetric reaction involves using the opposite enantiomeric catalyst. For the Michael addition of 4‐substituted‐5‐pyrazolones (1) to 1,4‐dicarbonyl but‐2‐enes (2) catalyzed by rare earth with the chiral N,N′‐dioxide derivative ligand (L), the product enantioselectivity was switched only by changing the rare earth from Sc to Y. To understand the mechanism, we investigated the reaction energy profile using the density functional theory combined with the automated reaction path search method. The enantioselectivity on 1 was determined by the coordination structure of the pre‐reaction complex. The pre‐reaction complex of the Sc system was ScL(OTf)1, where only the Si‐face attack of 2 was blocked. Conversely, the pre‐reaction complex of the Y system had one more triflate anion, (YL(OTf)21), which stabilized the different coordination structure, where only the Re‐face attack of 2 was blocked. The origin of the diastereoselectivity was also investigated based on the transition states (TSs) of the C−C bond formation. The orientation of 2 at the TSs was fixed because of the proton transfer, which destabilized the TS affording the minor diastereomer.