bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Evaluation of the Interappointment Pain by Using Different Intracanal Medicaments—An In Vivo Study
Authors: Jindal Varun , Monga Sahil , Jindal Deepti 
Published: April 2019

Abstract
Objective The purpose of this in vivo study was to evaluate pain using different intracanal medicaments.
Materials and Methods Seventy-five permanent single-rooted mandibular premolars with acute apical periodontitis were selected for this study. After access cavity preparation and cleaning and shaping of canals, patients were randomly divided into five groups with different intracanal medicaments viz calcium hydroxide paste, calcium hydroxide points, triple antibiotic paste, and Ledermix paste. Interappointment pain was recorded by the patient using visual analog scale after 6 hours, 12 hours, 18 hours, 24 hours, 2 days, 3 days, 4 days, 5 days, and 6 days of intracanal medicament dressing.
Results Ledermix paste showed highly significant results in reducing the interappointment pain as compared with calcium hydroxide paste, calcium hydroxide points, and triple antibiotic paste.
Conclusion Patients with Ledermix as intracanal medicament had minimum interappointment pain.
Clival Metastasis of Hepatocellular Carcinoma with an Initial Histopathological Diagnosis of Atypical Pituitary Adenoma
Authors: Mishima Hiroyuki , Ayabe Junichi , Watanabe Masahide , Togin Sota , Tsuchiya Yuusuke , Kawasaki Taisuke , Noda Naoyuki , Maruyama Takumi , Tanaka Yoshihide 
Published: April 2019

AbstractHistologically, hepatocellular carcinoma (HCC) and atypical pituitary adenoma are similar, posing a potential clinical problem. A 76-year-old woman, whose past medical history was significant for hepatitis C virus (HCV), positivity without liver cirrhosis was presented with abducens nerve (CN VI) palsy. Contrast-enhanced magnetic resonance imaging (MRI) showed a clival tumor with infiltration of the right cavernous sinus. Subtotal resection was performed using a right anterior petrosal approach. Histological diagnosis was pituitary adenoma. Thirty-four days after the operation, MRI imaging showed residual tumor growth without any liver masses on computed tomography (CT). The patient underwent a second operation using an endoscopic transnasal transsphenoidal approach. Histological examination of the specimen gave a positive reaction for α-fetoprotein. Repeat whole-body CT showed an enhanced liver mass. Based on these findings, the lesion was diagnosed as metastatic HCC. The patient died of liver failure 6 months later. In this case, tumor diagnosis was difficult because of the histological similarity of HCC and pituitary adenoma, and the fact that the clival tumor grew prior to presentation of the liver mass on CT. This case emphasizes the importance of comparing the pathological diagnosis with the patient's clinical course.
Utility, Risk and Demand for Incomplete Insurance: Lab Experiments with Guatemalan Co-Operatives
Authors: McIntosh Craig , Povel Felix , Sadoulet Elisabeth 
Published: April 2019

Abstract
We play a series of incentivised laboratory games with risk-exposed co-operativised Guatemalan coffee farmers to understand the demand for index-based rainfall insurance. We estimate an explicit utility curve for every player and hence predict expected utility demand under counterfactual scenarios. Using these estimates, we provide a precise money-metric decomposition of the extent to which the low observed demand for index insurance is driven by expected utility theory, or by behavioural issues arising from a prospect-style utility structure. Our results suggest that consumers value probabilistic insurance using a prospect-style utility function that is concave both in probabilities and in income.
Frontstage and Backstage in Argentina’s Transitional Justice Drama: The Niet@s’ Reconstruction of Identity on Social Media
Authors: Goldschmidt-Gjerløw Beate , Remkes Merel 
Published: April 2019

Abstract∞
This article provides new insight into how the ‘found grandchildren’ of postconflict Argentina are reconstructing their sense of self and identity after having been identified as children of disappeared political activists in the aftermath of the last military regime (1976–1983). We offer tools for understanding how they respond to the context-specific transitional justice measures of identification and restitution, and how this plays out on social media. This online world expands the possibilities to both share and comment on personal and public information. The narrative analysis discusses how our informants influence the Argentine transitional justice process by using social media as a stage for the performance of their life stories. However, their digital presentation of self is constrained to a certain extent by potential social reactions.
Bacteriologic Profile of Burn Wounds at a Tertiary Government Hospital in the Philippines—UP-PGH ATR Burn Center
Authors: Abesamis Gerald Marion M , Cruz Jose Joven V 
Published: April 2019

AbstractWound infection is a major cause of morbidity and mortality among burn patients. Recent changes in the epidemiology of burn wound infections were observed due to the steady rise of drug-resistant bacteria. The objective of this study is to determine the most common burn wound pathogens isolated among patients admitted at the UP-PGH ATR Burn Center, describe their respective susceptibility patterns, and calculate incidence rates of burn wound colonization, local, and invasive infection. Patients admitted at the UP-PGH Burn Center from March 2015 to February 2016 with tissue culture studies were monitored for development of wound infection; patient charts, tissue isolates, and their susceptibility patterns were reviewed. A total of 77 patients were included in the study wherein 36% had no infection, 42% had wound colonization, and 22% developed burn wound infection. Among these patients, 98 specimens were sent for culture studies which revealed Acinetobacter baumannii (25.6%) as the top pathogen isolated, followed by Enterococcus sp. (21.95%), and Pseudomonas sp. (18.29%). Acinetobacter baumannii was also the top isolate among patients with local and invasive infection (86 and 67%, respectively). Multidrug resistance was observed with A. baumannii and Pseudomonas exhibiting resistance towards meropenem, imipenem, cefepime, ciprofloxacin, and piperacillin-tazobactam but remained sensitive to colistin, amikacin, and minocycline. Vancomycin, cotrimoxazole, and ciprofloxacin were active against Gram-positive bacteria. Multidrug-resistant organisms pose a major risk in all burn units. To limit their growth, judicious use of antibiotics, aggressive infection control measures, close surveillance, and frequent antibiograms are needed.
A salivary ferritin in the whitefly suppresses plant defenses and facilitates host exploitation
Authors: Su Qi , Peng Zhengke , Tong Hong , Xie Wen , Wang Shaoli , Wu Qingjun , Zhang Jianmin , Li Chuanren , Zhang Youjun 
Published: April 2019

AbstractThe whitefly Bemisia tabaci is an important pest of worldwide agriculture. Previous work has shown that B. tabaci actively suppresses host plant defenses, but our knowledge of the specific mechanisms involved remains limited. Here we describe a B. tabaci salivary protein, the ferritin BtFer1, and its role in facilitating exploitation of host plants. We show that BtFer1 exhibits Fe2+ binding ability and ferroxidase activity, and that secretion of BtFer1 during B. tabaci feeding suppresses H2O2-generated oxidative signals in tomato (Solanum lycopersicum). Silencing BtFer1 enhanced the induction of the jasmonic acid (JA)-mediated defense signaling pathway in response to whitefly feeding, and led to increased callose deposition and the production of proteinase inhibitors that prevent whiteflies from continuously ingesting and digesting phloem sap. Consistent with these effects, silencing BtFer1 reduced whitefly survival on tomato but not on artificial diet. Using a JA-deficient spr2 mutant plant further showed that suppression of JA defenses by BtFer1 is sufficient to increase B. tabaci survival. Taken together, these results demonstrate that BtFer1 acts as an effector protein that mediates whitefly–tomato interactions. These findings represent an important step forward in understanding the molecular mechanisms by which whiteflies and other insect herbivores suppress host plant defenses.
The Burden of Dental Emergencies, Oral-Maxillofacial, and Cranio-Maxillofacial Injuries in US Military Personnel
Authors: Lee Laura , Dickens Noel , Mitchener Timothy , Qureshi Iram , Cardin Sylvain , Simecek John 
Published: April 2019

Abstract

Introduction
High numbers of dental emergencies (DE) in military service members (approximately 15% per annum) prompted the inclusion of Dental Readiness as one of six conditions that determine service members’ Individual Medical Readiness (IMR). Additionally, even with the advances in body armor and helmet design, Cranio- and Oral-maxillofacial (CMF, OMF) injuries continue to occur in hostile environments. The objectives of this report are (1) to provide a comprehensive review of the incidence of DE and CMF/OMF injuries in US military personnel deployed in multiple environments and (2) to compare the rates of DE and CMF/OMF injuries occurring in the 20th century with the rates observed in the early 21st century.

Materials and Methods
Published and unpublished studies, as well as military reports of DE, OMF, and CMF injuries occurring in US military personnel were evaluated. Study publication dates included 1955 to 2017, with data collection periods from 1941 through 2014.

Results
The results of 30 investigations were reviewed. Overall, the reported annual DE rates varied widely among US military personnel between 1966 and 2012, ranging from 26 to 324 (mean 152.2) DE per 1,000 personnel per year (PPY). The average annual incidence of DE for personnel in hostile environments was 125.1 per 1,000 PPY. Thirteen studies reported rates of OMF-CMF injuries from 1941 to 2014. The overall mean OMF injury rate in Operation Enduring Freedom (OEF) was 2.8 per 1,000 PPY, while the mean rate during Operation Iraqi Freedom (OIF)/Operation New Dawn (OND) was 3.2 per 1,000 PPY. A mean of 22.3 CMF injuries per 1,000 PPY was calculated from two reports during OIF.

Conclusions
The percentage of DE and OMF casualties that can be expected in hostile environments is approximately 12%. Using the most recent data since 2000, the mean DE rate was 118.2 per 1,000 PPY and the OMF rate was 3.0 per 1,000 PPY. Future research should yield information which is representative of the evolving military environment. This information should be used to enhance military-specific dental therapies and to guide protection of the craniofacial region. More importantly, quality data are necessary (1) to enable the accurate prediction of DE, CMF, and OMF casualties to insure that troop levels are sufficient for mission success and (2) to insure that all outcome variables are available to measure policy success or failure.
PRELIMINARY EVALUATION OF A HAND-MADE RADIATION MONITOR’S POTENTIAL FOR PROVIDING ENERGY INFORMATION AS AN ADDITIONAL FEATURE FOR SECONDARY LEVEL RADIATION EDUCATION
Authors: Katengeza E W , Ozaki S , Kato T , Kakefu T , Iimoto T 
Published: April 2019

Abstract
A hand-made air GM counter was developed using simple, low-cost and easily available materials. The detector was successful in demonstrating the inverse square law, shielding effect, and determining the half-life of thoron gas. The possibility of using the tube design as a simple proportional counter to provide energy information has been explored and preliminary experiment and simulation results appear to agree at low energy. The energy deposition characteristics for an internally placed alpha-emitting Rn-220 were simulated using Particle and Heavy Ion Transport code System (PHITS).
Neural responses for evaluating self and mother traits in adolescence depend on mother–adolescent relationships
Authors: Van der Cruijsen Renske , Buisman Renate , Green Kayla , Peters Sabine , Crone Eveline A 
Published: April 2019

AbstractAn important task in adolescence is to achieve autonomy while preserving a positive relationship with parents. Previous fMRI studies showed largely overlapping activation in medial prefrontal cortex (mPFC) for evaluating self and close-other traits but separable activation for self and non-close other. Possibly, more similar mPFC activation reflects closeness or warmth in relationships. We investigated neural indicators of the mother–adolescent relationship in adolescents between 11 and 21 years (N = 143). Mother–adolescent relationship was measured using (i) mothers’ and adolescents’ trait evaluations about each other, (ii) observations of warmth, negativity and emotional support in mother–adolescent conversation and (iii) similarity in adolescents’ neural activation for evaluating self vs mother traits. Results showed relatively more similar mPFC activation in adolescents who evaluated their mothers’ traits more positively, suggesting that this is possibly a neural indicator of mother–adolescent relationship quality. Furthermore, mid-adolescence was characterized by more negative mother–adolescent interaction compared to early and late adolescence. This effect co-occurred with mid-adolescent peaks in dorsal striatum, dorsal anterior cingulate cortex and superior temporal sulcus activation in evaluating traits of self vs mother. These results suggest more negative relationships and stronger self-focus in mid-adolescence.
Tree-ring isotopes suggest atmospheric drying limits temperature–growth responses of treeline bristlecone pine
Authors: de Boer Hugo J , Robertson Iain , Clisby Rory , Loader Neil J , Gagen Mary , Young Giles H F , Wagner-Cremer Friederike , Hipkin Charles R , McCarroll Danny 
Published: April 2019

AbstractAltitudinally separated bristlecone pine populations in the White Mountains (California, USA) exhibit differential climate–growth responses as temperature and tree-water relations change with altitude. These populations provide a natural experiment to explore the ecophysiological adaptations of this unique tree species to the twentieth century climate variability. We developed absolutely dated annual ring-width chronologies, and cellulose stable carbon and oxygen isotope chronologies from bristlecone pine growing at the treeline (~3500 m) and ~200 m below for the period AD 1710–2010. These chronologies were interpreted in terms of ecophysiological adaptations to climate variability with a dual-isotope model and a leaf gas exchange model. Ring widths show positive tree growth anomalies at treeline and consistent slower growth below treeline in relation to the twentieth century warming and associated atmospheric drying until the 1980s. Growth rates of both populations declined during and after the 1980s when growing-season temperature and atmospheric vapour pressure deficit continued to increase. Our model-based interpretations of the cellulose stable isotopes indicate that positive treeline growth anomalies prior to the 1980s were related to increased stomatal conductance and leaf-level transpiration and photosynthesis. Reduced growth since the 1980s occurred with a shift to more conservative leaf gas exchange in both the treeline and below-treeline populations, whereas leaf-level photosynthesis continued to increase in response to rising atmospheric CO2 concentrations. Our results suggest that warming-induced atmospheric drying confounds positive growth responses of apparent temperature-limited bristlecone pine populations at treeline. In addition, the observed ecophysiological responses of attitudinally separated bristlecone pine populations illustrate the sensitivity of conifers to climate change.
The thin edge of the wedge: extremely high extinction risk in wedgefishes and giant guitarfishes
Authors: Kyne Peter M. , Jabado Rima W. , Rigby Cassandra L. , Dharmadi  , Gore Mauvis A. , Pollock Caroline M. , Herman Katelyn B. , Cheok Jessica , Ebert David A. , Simpfendorfer Colin A. , Dulvy Nicholas K. 
Published: April 2019

AbstractThe process of understanding the rapid global decline of sawfishes (Pristidae) has revealed great concern for their relatives, the wedgefishes (Rhinidae) and giant guitarfishes (Glaucostegidae), not least because all three families are targeted for their high-value and internationally-traded ‘white’ fins.The objective of this study was to assess the extinction risk of all 10 wedgefishes and 6 giant guitarfishes by applying the International Union for Conservation of Nature (IUCN) Red List Categories and Criteria, and to summarise their biogeography and habitat, life history, exploitation, use and trade, and population status.Wedgefishes and giant guitarfishes have overtaken sawfishes as the most imperilled marine fish families globally, with all but one of the 16 species facing an extremely high risk of extinction due to a combination of traits – limited biological productivity, presence in shallow waters overlapping with some of the most intense and increasing coastal fisheries in the world, and over-exploitation in target and bycatch fisheries driven by the need for animal protein and food security in coastal communities and trade in meat and high-value fins.Two species with very restricted ranges, the Clown Wedgefish (Rhynchobatus cooki) of the Indo-Malay Archipelago and the False Shark Ray (Rhynchorhina mauritaniensis) of Mauritania may be very close to extinction.Only the Eyebrow Wedgefish (Rhynchobatus palpebratus) is not assessed as Critically Endangered, due to it occurring primarily in Australia where fishing pressure is low, and some management measures are in place. Australia represents a ‘lifeboat’ for the three wedgefish and one giant guitarfish species occurring there.To conserve populations and permit recovery, a suite of measures will be required which will need to include species protection, spatial management, bycatch mitigation, and harvest and international trade management, all of which will be dependent on effective enforcement.
Uncovering complex disease subtypes by integrating clinical data and imputed transcriptome from genome-wide association studies: Applications in psychiatry and cardiovascular medicine
Authors: Yin Liangying , Chau Carlos K.L. , Sham Pak-Chung , So Hon-Cheong 
Published: April 2019

AbstractClassifying patients into clinically and biologically homogenous subgroups will facilitate the understanding of disease pathophysiology and development of more targeted prevention and intervention strategies. Traditionally, disease subtyping is based on clinical characteristics alone, however disease subtypes identified by such an approach may not conform exactly to the underlying biological mechanisms. Very few studies have integratedgenomic profiles(such as those from GWAS) with clinical symptoms for disease subtyping.In this study, we proposed a novel analytic framework capable of finding subgroups of complex diseases by leveraging both GWAS-predicted gene expression levels and clinical data by a multi-view bicluster analysis. This approach connects SNPs to genes via their effects on expression, hence the analysis is more biologically relevant and interpretable than a pure SNP-based analysis. Transcriptome of different tissues can also be readily modelled. We also proposed various new evaluation or validation metrics, such as a newly modified ‘prediction strength’ measure to assess generalization of clustering performance. The proposed framework was applied to derive subtypes for schizophrenia, and to stratify subjects into different levels of cardiometabolic risks.Our framework was able to subtype schizophrenia patients with diverse prognosis and treatment response. We also applied the framework to the Northern Finland Cohort (NFBC) 1966 dataset, and identified high- and low cardiometabolic risk subgroups in a gender-stratified analysis. Our results suggest a more data-driven and biologically-informed approach to defining metabolic syndrome. The prediction strength was over 80%, suggesting that the cluster model generalizes well to new datasets. Moreover, we found that the genes ‘blindly’ selected by the cluster algorithm are significantly enriched for known susceptibility genes discovered in GWAS of schizophrenia and cardiovascular diseases, providing further support to the validity of our approach. The proposed framework may be applied to any complex diseases, and opens up a new approach to patient stratification.
The biochemical activities of the Saccharomyces cerevisiae Pif1 helicase are regulated by its N-terminal domain
Authors: Nickens David G. , Sausen Christopher W. , Bochman Matthew L. 
Published: April 2019

AbstractPIF1 family helicases represent a highly conserved class of enzymes involved in multiple aspects of genome maintenance. Many PIF1 helicase are multi-domain proteins, but the functions of their non-helicase domains are poorly understood. Here, we characterized how the N-terminal domain (NTD) of theSaccharomyces cerevisiaePif1 helicase affects its functions bothin vivoandin vitro. Removal of the Pif1 NTD alleviated the toxicity associated with Pif1 over-expression in yeast. Biochemically, the N-terminally truncated Pif1 (Pif1ΔN) retainedin vitroDNA binding, DNA unwinding, and telomerase regulation activities, but these activities differed markedly from those displayed by full-length recombinant Pif1. However, Pif1ΔN was still able to synergize with the Hrq1 helicase to inhibit telomerase activityin vitro, similar to full-length Pif1. These data impact our understanding of PIF1 helicase evolution and the roles of these enzymes in the maintenance of genome integrity.
RNA base pairing complexity in living cells visualized by correlated chemical probing
Authors: Mustoe Anthony M. , Lama Nicole , Irving Patrick S. , Olson Samuel W. , Weeks Kevin M. 
Published: April 2019

ABSTRACTRNA structure and dynamics are critical to biological function. However, strategies for determining RNA structure in vivo are limited, with established chemical probing and newer duplex detection methods each having notable deficiencies. Here we convert the common reagent dimethyl sulfate (DMS) into a useful probe of all four RNA nucleotides. Building on this advance, we introduce PAIR-MaP, which uses single-molecule correlated chemical probing to directly detect base pairing interactions in cells. PAIR-MaP has superior resolution and accuracy compared to alternative experiments, can resolve alternative pairing interactions of structurally dynamic RNAs, and enables highly accurate structure modeling, including of RNAs containing multiple pseudoknots and extensively bound by proteins. Application of PAIR-MaP to human RNase MRP and two bacterial mRNA 5'-UTRs reveals new functionally important and complex structures undetectable by conventional analyses. PAIR-MaP is a powerful, experimentally concise, and broadly applicable strategy for directly visualizing RNA base pairs and dynamics in cells.