bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily Intake of Sodium and Potassium Among Diverse US Hispanics/Latinos, the Hispanic Community Health Study/Study of Latinos
Authors: Elfassy Tali , Sotres-Alvarez Daniela , Van Horn Linda , Angell Sonia , Schneiderman Neil , Rundek Tatjana , Raij Leopoldo , Smoller Sylvia W , Mossavar-Rahmani Yasmin , Daviglus Martha L , Hanna David B , Zeki Al Hazzouri Adina 
Published: May 2019

Abstract

BACKGROUND
High sodium and low potassium consumption are risk factors for hypertension. The objectives of this study were to describe usual daily intake of sodium and potassium among US Hispanics/Latinos of diverse background groups and estimate the proportion meeting guidelines for dietary sodium and potassium intake.

METHODS
We studied 16,171 participants of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a diverse group of self-identified Hispanics/Latinos aged 18–74 years from 4 US communities. In 2008–2011, all HCHS/SOL participants underwent a standardized examination. Median usual daily intake of dietary sodium and potassium were derived from two 24-hour diet recalls; standard errors and 95% confidence intervals (CIs) were calculated using boot strap methods. Meeting 2015 US Department of Agriculture guidelines was defined as an intake of &lt;2,300 mg/day of sodium and ≥4,700 mg/day of potassium.

RESULTS
Among US Hispanics/Latinos, median usual daily intake of sodium was 2,574 mg (95% CI: 2,547, 2,600) among women and 3,747 mg (95% CI: 3,697, 3,796) among men. Median usual daily intake of potassium was 2,069 mg (95% CI: 2,046, 2,092) among women and 2,649 mg (95% CI: 2,615, 2,683) among men. Overall, only 21.3% (95% CI: 20.2%, 22.4%) of the US Hispanic/Latino population met 2015 recommendations for sodium and 0.6% (95% CI: 0.4%, 0.8%) for potassium.

CONCLUSIONS
Among US Hispanics/Latinos intake of sodium is too high and potassium too low. Strategies to reduce sodium intake while simultaneously increasing intake of potassium in this US population are warranted.
Conserving wildlife in a changing world: Understanding capture myopathy—a malignant outcome of stress during capture and translocation
Authors: Breed Dorothy , Meyer Leith C R , Steyl Johan C A , Goddard Amelia , Burroughs Richard , Kohn Tertius A 
Published: May 2019

AbstractThe number of species that merit conservation interventions is increasing daily with ongoing habitat destruction, increased fragmentation and loss of population connectivity. Desertification and climate change reduce suitable conservation areas. Physiological stress is an inevitable part of the capture and translocation process of wild animals. Globally, capture myopathy—a malignant outcome of stress during capture operations—accounts for the highest number of deaths associated with wildlife translocation. These deaths may not only have considerable impacts on conservation efforts but also have direct and indirect financial implications. Such deaths usually are indicative of how well animal welfare was considered and addressed during a translocation exercise. Importantly, devastating consequences on the continued existence of threatened and endangered species succumbing to this known risk during capture and movement may result. Since first recorded in 1964 in Kenya, many cases of capture myopathy have been described, but the exact causes, pathophysiological mechanisms and treatment for this condition remain to be adequately studied and fully elucidated. Capture myopathy is a condition with marked morbidity and mortality that occur predominantly in wild animals around the globe. It arises from inflicted stress and physical exertion that would typically occur with prolonged or short intense pursuit, capture, restraint or transportation of wild animals. The condition carries a grave prognosis, and despite intensive extended and largely non-specific supportive treatment, the success rate is poor. Although not as common as in wildlife, domestic animals and humans are also affected by conditions with similar pathophysiology. This review aims to highlight the current state of knowledge related to the clinical and pathophysiological presentation, potential treatments, preventative measures and, importantly, the hypothetical causes and proposed pathomechanisms by comparing conditions found in domestic animals and humans. Future comparative strategies and research directions are proposed to help better understand the pathophysiology of capture myopathy.
Psychological and Social Factors Associated with Pain in Inflammatory Bowel Disease: A Systematic Literature Review of the Evidence in Adult and Pediatric Studies
Authors: Robertson Noelle , Gunn Sarah , Piper Rebecca 
Published: May 2019

Abstract

Background
Pain is commonly experienced in both active and dormant inflammatory bowel disease (IBD). Psychological and social factors, which can be key to pain experience, have been relatively neglected; the only prior comprehensive review focused solely on studies of adults. The present review, therefore, sought to systematically examine relationships between pediatric and adult experience of pain and psychosocial variables.

Method
Systematic searches of 5 databases were conducted to identify studies including measures of pain and psychosocial variables, in pediatric or adult IBD populations. Quality appraisal of studies was undertaken using a qualified assessment tool.

Results
Twenty-three articles met the inclusion criteria. Ten examined relationships between pain and psychosocial variables in adults, and 13 examined in pediatric populations. Inverse relationships were identified between pain and quality of life (QOL) in both populations, with potential differences in pain localization between the two populations. Psychological distress, notably depression, was also important in both populations, with inconsistent evidence for a role for anxiety in pediatric samples. Specific coping styles, and familial responses to communications, also appeared relevant, but with weaker evidence. There was substantial heterogeneity in measures, statistical analyses and sample characteristics, and quality appraisal revealed methodological weaknesses.

Conclusions
Significant relationships were found between pain and various psychological indices, notably QOL and depression. However, most studies were underpowered, did not sufficiently control for key confounds, and almost exclusively reported on Western participants. Adequately powered, statistically sound studies encompassing diverse populations are required to further clarify relationships between pain and psychosocial variables in IBD.
The complexity of alternative splicing and landscape of tissue-specific expression in lotus (Nelumbo nucifera) unveiled by Illumina- and single-molecule real-time-based RNA-sequencing
Authors: Zhang Yue , Nyong'A Tonny Maraga , Shi Tao , Yang Pingfang 
Published: May 2019

Abstract
Alternative splicing (AS) plays a critical role in regulating different physiological and developmental processes in eukaryotes, by dramatically increasing the diversity of the transcriptome and the proteome. However, the saturation and complexity of AS remain unclear in lotus due to its limitation of rare obtainment of full-length multiple-splice isoforms. In this study, we apply a hybrid assembly strategy by combining single-molecule real-time sequencing and Illumina RNA-seq to get a comprehensive insight into the lotus transcriptomic landscape. We identified 211,802 high-quality full-length non-chimeric reads, with 192,690 non-redundant isoforms, and updated the lotus reference gene model. Moreover, our analysis identified a total of 104,288 AS events from 16,543 genes, with alternative 3ʹ splice-site being the predominant model, following by intron retention. By exploring tissue datasets, 370 tissue-specific AS events were identified among 12 tissues. Both the tissue-specific genes and isoforms might play important roles in tissue or organ development, and are suitable for ‘ABCE’ model partly in floral tissues. A large number of AS events and isoform variants identified in our study enhance the understanding of transcriptional diversity in lotus, and provide valuable resource for further functional genomic studies.
Endo-sponge Assisted Early Surgical Closure of Ileal Pouch-anal Anastomotic Leakage Preserves Long-term Function: A Cohort Study
Authors: Wasmann Karin A , Reijntjes Maud A , Stellingwerf Merel E , Ponsioen Cyriel Y , Buskens Christianne J , Hompes Roel , Tanis Pieter J , Bemelman Willem A 
Published: May 2019

AbstractBackground and AimsEndo-sponge [Braun Medical] assisted early surgical closure [ESC] is an effective treatment to control pelvic sepsis after ileal pouch-anal anastomosis [IPAA] leakage, and became standard treatment in our centre from 2010 onwards. The aim of this cohort study was to assess the long-term pouch function of ulcerative colitis [UC] patients treated with ESC or conventional management [CM] for anastomotic leakage after IPAA.MethodsConsecutive patients who underwent an IPAA for UC between 2002 and 2017 were included. Patients treated with ESC [2010–2017] or CM [2002–2009] for anastomotic leakage were compared with control patients without anastomotic leakage of the corresponding time period. Main endpoints were long-term pouch function on a 3-point scale and pouch failure, as measured with the validated pouch dysfunction score questionnaire.ResultsSome 280 of 334 patients [84%] returned the pouch dysfunction questionnaire, of whom 18 were treated with ESC and 22 with CM for anastomotic leakage. Control cohorts included 133 [2010–2017] and 107 patients [2002–2009]. Between ESC-treated patients and control patients, pouch function [p = 0.647] and pouch failure rates [0/18 versus 5/133, p &gt;0.99] were similar. CM resulted in worse pouch function [p = 0.016] and a higher pouch failure rate [5/22 versus 5/107, p = 0.013] compared with control patients.ConclusionsESC, in contrast to CM, for IPAA leakage in UC patients is associated with preservation of pouch function and preclusion of pouch failure, probably due to early and effective treatment of pelvic sepsis.
The Survival of Mediterranean Fruit Fly (Diptera: Tephritidae) Over Winter in Western Australia
Authors: Rahman Touhidur , Broughton Sonya 
Published: May 2019

Abstract
The Mediterranean fruit fly, Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) is one of the most economically important pest insects of fruit crops worldwide. Mediterranean fruit fly can cause up to 100% crop loss in susceptible fruit. In order to formulate best management practices, it is critical to understand how Mediterranean fruit fly overwinters in a given geographical location and bridge the gap between autumn and spring populations. In this study, we evaluated the overwintering potential of Mediterranean fruit fly immature and adult stages in two locations in Perth Hills, Western Australia. We also monitored wild adult Mediterranean fruit fly populations for 2 yr. Adults were present year-round with captures very low in winter to early spring relative to summer and autumn. Field experiments revealed that immature stages in apples (eggs/first instar) and soil (pupae) remained viable in winter, emerging as adults at the onset of warmer weather in spring. In field cages, adults survived 72–110 d, and female laid viable eggs when offered citrus fruit, though only 1–6% eggs survived to emerge as adults. Adults survived longer in field cages when offered live citrus branch. The findings suggest that all Mediterranean fruit fly life stages can survive through mild winter, and surviving adults, eggs in the fruit and/or pupae in the soil are the sources of new population that affect the deciduous fruit crops in Perth. We recommend that Mediterranean fruit fly monitoring is required year-round and control strategies be deployed in spring. Furthermore, we recommend removal of fallen fruit particularly apple and other winter fruit such as citrus.
A case report: X-linked dystrophin gene mutation causing severe isolated dilated cardiomyopathy
Authors: Lester Geoffrey , Femia Giuseppe , Ayer Julian , Puranik Rajesh 
Published: May 2019

Abstract

Background
X-linked dilated cardiomyopathy (XLDCM) is a rare but rapidly progressive cardiomyopathy caused by dystrophin gene mutation. Mutations are more often associated with Duchenne and Becker Muscular Dystrophy, which are characterized by skeletal muscle weakness or limb girdle dystrophy. However, patients with isolated XLDCM have normal skeletal muscle but complete dystrophin loss in cardiac muscle resulting in isolated myocardial involvement without overt signs of skeletal myopathy.

Case summary
A previously well 16-year-old boy developed sudden onset dense left-sided weakness and facial droop. Computed tomography (CT) angiography and CT brain showed an occluded right internal carotid artery extending to the right middle cerebral artery. He underwent successful endovascular clot retrieval but developed frank pulmonary oedema and cardiogenic shock requiring inotropic support and intubation. Transthoracic echocardiography demonstrated severe left ventricular (LV) cardiomyopathy and an apical thrombus. Subsequent cardiac magnetic resonance (CMR) imaging confirmed the LV parameters and diffuse late gadolinium enhancement. Despite absence of skeletal manifestations, subsequent genetic testing revealed an X-linked dystrophin gene mutation [c.31+G>T (IVS1G>T)]. He was commenced on empirical heart failure therapy and underwent successful cardiac transplantation.

Discussion
X-linked dilated cardiomyopathy is a rare, rapidly progressing cardiomyopathy. Patients show normal skeletal muscle dystrophin but absent expression in cardiac muscle, resulting fibrosis, and atrophy. About 20% of affected young males have significantly reduced survival and thus the diagnosis must be considered in cases of idiopathic cardiomyopathy with CMR and genetic testing key to the diagnosis. Whilst evidence exists for empirical heart failure medications, cardiac transplantation remains the definitive treatment.
Stress-Buffering Effects of Volunteering on Daily Well-Being: Evidence From the National Study of Daily Experiences
Authors: Han Sae Hwang , Kim Kyungmin , Burr Jeffrey A 
Published: May 2019

Abstract

Objectives
Building on theoretical frameworks and empirical evidence linking volunteering and well-being in later life, we investigated the associations between daily engagement in formal volunteering, stressors, and negative and positive affect, focusing on the stress-buffering effect of volunteering.

Methods
We used 8 days of daily diary data from the second wave of the National Study of Daily Experiences (NSDE II), a national survey of middle-aged and older adults (participant N = 1,320; participant-day observation N = 8,277). A series of multilevel models were estimated to assess the within-person associations between daily volunteering, stressors, and affect.

Results
A direct link between daily volunteering and affect was not discovered. However, we found that the association between daily stressors and negative affect (but not positive affect) was weaker on days when volunteering was performed compared to days volunteering was not performed.

Discussion
Our findings suggested that the stress-buffering effect of volunteering contributes to improved emotional well-being for participants who volunteered on a daily basis. Future studies should investigate whether such stress-buffering effects are present for other forms of helping behaviors.
Inappropriate use of medicines and associated factors in Brazil: an approach from a national household survey
Authors: Luiza Vera Lucia , Mendes Luiz Villarinho Pereira , Tavares Noemia Urruth Leão , Bertoldi Andrea Damaso , Fontanella Andréia Turmina , Oliveira Maria Auxiliadora , Campos Mônica Rodrigues ,   PNAUM Group, Arrais Paulo Sergio Dourado , Ramos Luiz Roberto , da Silva Dal Pizzol Tatiane , Mengue Sotero Serrate , Farias Mareni Rocha 
Published: May 2019

Abstract
This article aims to describe the inappropriate use of medicines in the Brazilian urban population and to identify associated factors. We conducted a data analysis of a household survey carried out in Brazil in 2013–14. The sampling plan was done by clusters with representativeness of the urban population and large regions of the country, according to gender and age domains. For this analysis, we considered a sample of adults (≥20 years) who reported having chronic non-communicable diseases, medical indication for drug treatment and medicine use (n = 12 283). We evaluated the prevalence of inappropriate use in the domains: non-adherence, inappropriate use behaviour and inadequate care with medicines, all verified in the following groups of independent variables: demographic and socio-economic characteristics, health and pharmaceutical care, health status and use of medicines. Crude and adjusted prevalence ratios were obtained using robust Poisson regression. It was found 46.1% of people having at least one behaviour of inappropriate use of medicines. The worst results were found for the domain of inappropriate use behaviour, a situation of 36.6% of the users, which included unauthorized prescriber, inadequate source of information and indication of the medicines by non-authorized prescribers. The best result was found for the lack of medicines care, informed by only 4.6% of users who kept expired drugs at home. The inappropriate use of medicines was associated with gender (female), region of residence (Northeast), not visiting the doctor regularly or visiting more than one doctor, not having free access to medicines and using of five or more medicines. There was a high prevalence of inappropriate use, which was associated with both individual and health system characteristics pointing out the need to set priorities as for health education and public interventions.
Development of an Objective Model to Define Near-Term Risk of Ileocecal Resection in Patients with Terminal Ileal Crohn Disease
Authors: Grass Fabian , Fletcher Joel G , Alsughayer Ahmad , Petersen Molly , Bruining David H , Bartlett David J , Mathis Kellie L , Lightner Amy L 
Published: May 2019

Abstract

Background
The decision to either escalate medical therapy or proceed to ileocecal resection (ICR) in patients with terminal ileal Crohn disease (CD) remains largely subjective. We sought to develop a risk score for predicting ICR at 1 year from computed tomography or magnetic resonance enterography (CTE/MRE).

Methods
We conducted a retrospective cohort study including all consecutive adult (> 18 years) patients with imaging findings of terminal ileal CD (Montreal classification: B1, inflammatory predominant; B2, stricturing; or B3, penetrating) on CTE/MRE between January 1, 2016, and December 31, 2016. The risk for ICR at 6 months and at 1 year of CTE/MRE and risk factors associated with ICR, including demographics, CD-specific immunosuppressive therapeutics, and disease presentation at the time of imaging, were determined.

Results
Of 559 patients, 121 (21.6%) underwent ICR during follow-up (1.4 years [IQR 0.21–1.64 years]); the risk for ICR at 6 months and at 1 year was 18.2% (95% CI 14.7%–21.6%) and 20.5% (95% CI 16.8%–24.1%), respectively. Multivariable analysis revealed Montreal classification (B2, hazard ratio [HR] 2.73, and B3, HR 6.80, both P < 0.0001), upstream bowel dilation (HR 3.06, P < 0.0001), and younger age (19–29 years reference, 30–44 years, HR 0.83 [P = 0.40]; 45–59 years, HR 0.58 [P = 0.04], and 60+ years, HR 0.45 [P = 0.01]) to significantly increase the likelihood of ICR. A predictive nomogram for interval ICR was developed based on these significant variables.

Conclusions
The presence of CD strictures, penetrating complications, and upstream bowel dilation on CTE/MRE, combined with young age, significantly predict ICR. The suggested risk model may facilitate objective therapeutic decision-making.
Inoculum effect of β-lactam antibiotics
Authors: Lenhard Justin R , Bulman Zackery P 
Published: May 2019

AbstractThe phenomenon of attenuated antibacterial activity at inocula above those utilized for susceptibility testing is referred to as the inoculum effect. Although the inoculum effect has been reported for several decades, it is currently debatable whether the inoculum effect is clinically significant. The aim of the present review was to consolidate currently available evidence to summarize which β-lactam drug classes demonstrate an inoculum effect against specific bacterial pathogens. Review of the literature showed that the majority of studies that evaluated the inoculum effect of β-lactams were in vitro investigations of Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Haemophilus influenzae and Staphylococcus aureus. Across all five pathogens, cephalosporins consistently displayed observable inoculum effects in vitro, whereas carbapenems were less susceptible to an inoculum effect. A handful of animal studies were available that validated that the in vitro inoculum effect translates into attenuated pharmacodynamics of β-lactams in vivo. Only a few clinical investigations were available and suggested that an in vitro inoculum effect of cefazolin against MSSA may correspond to an increased likeliness of adverse clinical outcomes in patients receiving cefazolin for bacteraemia. The presence of β-lactamase enzymes was the primary mechanism responsible for an inoculum effect, but the observation of an inoculum effect in multiple pathogens lacking β-lactamase enzymes indicates that there are likely multiple mechanisms that may result in an inoculum effect. Further clinical studies are needed to better define whether interventions made in the clinic in response to organisms displaying an in vitro inoculum effect will optimize clinical outcomes.
Teaching Communication Skills in Breast Imaging
Authors: DeBenedectis Carolynn M 
Published: May 2019

Abstract
Breast radiologists communicate life-changing results to patients every day. It is critical for breast radiologists to be effective communicators and to deliver difficult and good news effectively and empathetically. Communication skills can be just as important as image interpretation and procedural skills in breast imaging. Breast radiologists can learn effective communication through practice. In addition, simulation-based communication skills training can help our trainees practice their communication skills in a low-stakes environment and become more comfortable with communicating difficult results. This manuscript sets out to familiarize breast radiologists with what effective communication skills are, as well as how to learn and teach them.