bluuebunny/crossref_metadata_2025_split huggingface dataset:
Out of Sight, Out of Mind? Geographic and Social Predictors of Flood Risk Awareness
Authors: Gray‐Scholz Daran , Haney Timothy J. , MacQuarrie Pamela 
Published: June 2019

AbstractThe persistent gap in flood risk awareness in Canada, and elsewhere in North America, is a continual source of worry for researchers and emergency managers; many people living in at‐risk places are simply unaware of risks and of their proximity to hazards. This study seeks to understand which residents were aware of flood risk, using unique representative survey data of Calgary residents living in the city's flood‐prone neighborhoods collected after the devastating and costly 2013 Southern Alberta Flood. The article uses logistic regression models to analyze which residents were aware of risk to their homes. Findings indicate that, in addition to various demographic predictors, many of the geographic predictors (including the elevation of one's home relative to the river) are significant predictors of awareness. Having a direct sight line to one of Calgary's two rivers is also a significant predictor in some of the models, suggesting that the visibility of hazards matters for flood risk perception, although this effect fades when many of the geographic predictors are added. Finally, the models indicate that several variables related to local, neighborhood‐based social networks are significant as well. These findings reveal that both physical surroundings and social context are important for understanding risk awareness. The article concludes by discussing the relevance for social science research on disasters and hazards, as well as for planners and emergency managers.
Quality of life and burden of caregivers of children and adolescents with disabilities
Authors: Barros Alina Lúcia Oliveira , de Gutierrez Gabriela Mancia , Barros Amanda Oliveira , Santos Maria Teresa Botti Rodrigues 
Published: June 2019

AbstractAimsTo evaluate the quality of life (QoL) and burden of primary caregivers of children and young adults (PCCYAs) with and without disabilities.MethodsA cross‐sectional study was carried out with sample composed of 336 PCCYAs with cerebral palsy (CP; n = 84), Down syndrome (DS; n = 84), autism spectrum disorder (ASD; n = 84), and without disabilities (control group: CG n = 84), matched by gender and age. The burden of caregivers was assessed with the Zarit Burden Interview (ZBI), whereas QoL was assessed using the WHOQOL‐BREF instrument.ResultsQoL and burden of CG presented better results compared to groups with disabilities, with the lowest environmental domain of all study groups (P <.001). The prevalence of burden was moderate for PCCAs of groups with disabilities. There was association between all WHOQOL‐BREF and ZBI domains and variables age, schooling, occupation and per capita income (Spearman's correlation coefficient, P <.05). There is a negative impact on WHOQOL‐BREF, with an increase in the level of burden of PCCAs with disabilities.ConclusionThe majority of PCCYAs were unemployed married mothers, with low schooling and health problems. Older caregivers experience even higher burden and greater impact on QoL.
Deposition and preservation of fluvio‐tidal shallow‐marine sandstones: A re‐evaluation of the Neoproterozoic Jura Quartzite (western Scotland)
Authors: Levell Bruce K. , Johnson Howard D. , Collins Daniel S. , van Cappelle Marijn 
Published: June 2019

AbstractThe 2 to 5 km thick, sandstone‐dominated (>90%) Jura Quartzite is an extreme example of a mature Neoproterozoic sandstone, previously interpreted as a tide‐influenced shelf deposit and herein re‐interpreted within a fluvio‐tidal deltaic depositional model. Three issues are addressed: (i) evidence for the re‐interpretation from tidal shelf to tidal delta; (ii) reasons for vertical facies uniformity; and (iii) sand supply mechanisms to form thick tidal‐shelf sandstones. The predominant facies (compound cross‐bedded, coarse‐grained sandstones) represents the lower parts of metres to tens of metres high, transverse fluvio‐tidal bedforms with superimposed smaller bedforms. Ubiquitous erosional surfaces, some with granule–pebble lags, record erosion of the upper parts of those bedforms. There was selective preservation of the higher energy, topographically‐lower, parts of channel‐bar systems. Strongly asymmetrical, bimodal, palaeocurrents are interpreted as due to associated selective preservation of fluvially‐enhanced ebb tidal currents. Finer‐grained facies are scarce, due largely to suspended sediment bypass. They record deposition in lower‐energy environments, including channel mouth bars, between and down depositional‐dip of higher energy fluvio‐ebb tidal bars. The lack of wave‐formed sedimentary structures and low continuity of mudstone and sandstone interbeds, support deposition in a non‐shelf setting. Hence, a sand‐rich, fluvial–tidal, current‐dominated, largely sub‐tidal, delta setting is proposed. This new interpretation avoids the problem of transporting large amounts of coarse sand to a shelf. Facies uniformity and vertical stacking are likely due to sediment oversupply and bypass rather than balanced sediment supply and subsidence rates. However, facies evidence of relative sea level changes is difficult to recognise, which is attributed to: (i) the areally extensive and polygenetic nature of the preserved facies, and (ii) a large stored sediment buffer that dampened response to relative sea‐level and/or sediment supply changes. Consideration of preservation bias towards high‐energy deposits may be more generally relevant, especially to thick Neoproterozoic and Lower Palaeozoic marine sandstones.
Molecular phylogeny ofHimalopsyche(Trichoptera, Rhyacophilidae)
Authors: Hjalmarsson Anna E. , Graf Wolfram , Vitecek Simon , Jähnig Sonja C. , Cai Qinghua , Sharma Subodh , Tong Xiaoli , Li Fengqing , Shah Deep Narayan , Shah Ram Devi Tachamo , Pauls Steffen U. 
Published: June 2019

AbstractSpecies of the genusHimalopsyche(Trichoptera, Rhyacophilidae) inhabit alpine to montane environments in Central and East Asia and North America. Diversity of the genus is concentrated primarily in the Himalayas and surrounding mountain ranges. Phylogenetic hypotheses have hitherto been proposed based on morphological data. Here, we present the first molecular phylogeny ofHimalopsychebased on six gene fragments, using three methods of phylogenetic inference. Based on the phylogenetic analyses, we re‐evaluated species groups suggested by previous authors based on adult male morphology. We found that the previously defined groups are largely supported by molecular evidence as well as larval and adult morphology. However, we modify the species groups so thatHimalopsyche phryganeaandHimalopsyche lepchaconstitute monotypic groups, and so that thetibetanagroup andanomalagroupsensuSchmid & Botosaneanu are merged to a single group, here defined as thetibetanagroup. Thus, we propose thatHimalopsychecan be divided into five groups:kuldschensisgroup,lepchagroup,navasigroup,phryganeagroup, andtibetanagroup. We also provide a biogeographic synthesis ofHimalopsychedistributions.
Thoracic high resolution CT using the modified VetMousetrap™ device is a feasible method for diagnosing canine idiopathic pulmonary fibrosis in awake West Highland White Terriers
Authors: Holopainen Saila , Rautala Elina , Lilja‐Maula Liisa , Lohi Hannes , Rajamäki Minna M. , Lappalainen Anu K. 
Published: June 2019

AbstractCanine idiopathic pulmonary fibrosis is a chronic, progressive interstitial lung disease particularly prevalent in West Highland White Terriers. In the present prospective pilot study, we evaluated the feasibility of modified VetMousetrap™ device in high resolution CT to detect idiopathic pulmonary fibrosis in West Highland White Terriers. Twelve awake West Highland White Terriers with canine idiopathic pulmonary fibrosis and 24 clinically healthy West Highland White Terriers were scanned using a helical dual slice scanner utilizing VetMousetrap™ device without or with minimal chemical restraint with butorphanol. Three evaluators blindly assessed the images for image quality and the presence of canine idiopathic pulmonary fibrosis related imaging findings such as ground glass opacity and reticular opacities. Additionally, the attenuation of the lung was quantified with ImageJ software using histogram analysis of density over the lung fields. Computed tomography was successfully completed and motion artifact ranked in statistical analysis barely noticeable to mild in all dogs. The agreement between imaging findings and clinical status was very good with overall κ value 0.91 and percentage of agreement of 94%. There was also very good intraobserver (κrange = 0.79‐0.91) and interobserver agreement (κ = 0.94). Moderate to severe ground glass opacity was present in all affected dogs. In the ImageJ analysis, a significant difference in lung attenuation between the study groups was observed. We conclude that modified VetMousetrap™ device is applicable in diagnosing canine idiopathic pulmonary fibrosis in awake West Highland White Terriers avoiding anesthetic risk in these often severely hypoxic patients.
The Effects of Leucine-Enriched Branched-Chain Amino Acid Supplementation on Recovery After High-Intensity Resistance Exercise
Authors: Osmond Adam D. , Directo Dean J. , Elam Marcus L. , Juache Gabriela , Kreipke Vince C. , Saralegui Desiree E. , Wildman Robert , Wong Michael , Jo Edward 
Published: June 2019

Context: Of the 3 branched-chain amino acids (BCAA), leucine has arguably received the most attribution for the role of BCAA supplementation in alleviating symptoms of exercise-induced muscle damage and facilitation of acute performance recovery. Purpose: To examine whether enrichment of a standard BCAA supplement with additional leucine or a standalone leucine (LEU) supplement differentially affects exercise-induced muscle damage and performance recovery compared with a standard BCAA supplement. Methods: A total of 22 recreationally active male and female subjects were recruited and assigned to consume a BCAA, leucine-enriched BCAA (LBCAA), or LEU supplement for 11 d. On the eighth day, subjects performed eccentric-based resistance exercise (ECRE). Lower-body mean average and peak power, plasma creatine kinase, soreness, and pain threshold were measured before and 24, 48, and 72 h after ECRE. Results: LEU showed decreased mean average power (P = .02) and mean peak power (P = .01) from baseline to 48 h post-ECRE, whereas LBCAA and BCAA only trended toward a reduction at 24 hours post-ECRE. At 48 h post-ECRE, BCAA showed greater recovery of mean peak power than LEU (P = .04). At 24 h post-ECRE, LEU demonstrated a greater increase in plasma creatine kinase from baseline than BCAA (P = .04). Area under the curve for creatine kinase was greater in LEU than BCAA (P = .02), whereas BCAA and LBCAA did not differ. Only LEU demonstrated increased soreness during rest and under muscular tension at 24 and 48 h post-ECRE (P < .05). Conclusions: LBCAA failed to afford any advantages over a standard BCAA supplement for postexercise muscle recovery, whereas a LEU supplement was comparatively ineffective.
The Temporal Relationship Between Exercise, Recovery Processes, and Changes in Performance
Authors: Skorski Sabrina , Mujika Iñigo , Bosquet Laurent , Meeusen Romain , Coutts Aaron J. , Meyer Tim 
Published: June 2019

Physiological and psychological demands during training and competition generate fatigue and reduce an athlete’s sport-specific performance capacity. The magnitude of this decrement depends on several characteristics of the exercise stimulus (eg, type, duration, and intensity), as well as on individual characteristics (eg, fitness, profile, and fatigue resistance). As such, the time required to fully recover is proportional to the level of fatigue, and the consequences of exercise-induced fatigue are manifold. Whatever the purpose of the ensuing exercise session (ie, training or competition), it is crucial to understand the importance of optimizing the period between exercise bouts in order to speed up the regenerative processes and facilitate recovery or set the next stimulus at the optimal time point. This implies having a fairly precise understanding of the fatigue mechanisms that contribute to the performance decrement. Failing to respect an athlete’s recovery needs may lead to an excessive accumulation of fatigue and potentially “nonfunctional overreaching” or to maladaptive training. Although research in this area recently increased, considerations regarding the specific time frames for different physiological mechanisms in relation to exercise-induced fatigue are still missing. Furthermore, recommendations on the timing and dosing of recovery based on these time frames are limited. Therefore, the aim of this article is to describe time courses of recovery in relation to the exercise type and on different physiological levels. This summary supports coaches, athletes, and scientists in their decision-making process by considering the relationship of exercise type, physiology, and recovery.
Session RPE During Prolonged Exercise Training
Authors: Fusco Andrea , Knutson Christine , King Charles , Mikat Richard P. , Porcari John P. , Cortis Cristina , Foster Carl 
Published: June 2019

Purpose: Although the session rating of perceived exertion (sRPE) is primarily a marker of internal training load (TL), it may be sensitive to external TL determining factors, such as duration and volume. Thus, sRPE could provide further information on accumulated fatigue not available from markers of internal TL. Therefore, the purpose of this study was to investigate sRPE during heavy training bouts at relatively constant intensity. Methods: Eleven university swimmers performed a high-volume training session consisting of 4 × 10 × 100-yd (4 × 10 × 91.4 m). Repetition lap time and heart rate were measured for each repetition and averaged for each set. Blood lactate concentration was measured after each set. At the end of each set, a 10-minute rest period was allowed, during which sRPE values were obtained, as if the training bout had ended. Results: There were no differences between sets for lap time (P = .096), heart rate (P = .717), and blood lactate concentration (P = .466), suggesting that the subjects were working at the same external and internal intensity. There was an increase (P = .0002) in sRPE between sets (first 4 [1.2], second 5 [1.3], third 7 [1.3], and fourth 8 [1.5]), suggesting that even when maintaining the same intensity, the perception of the entire workload increased with duration. Conclusions: Increases in duration, although performed with a consistent internal and external intensity, influences sRPE. These findings support the concept that sRPE may provide additional information on accumulated fatigue not available from other markers of TL.
Perceived physical health in obsessive-compulsive disorder: a protocol for a systematic review and meta-analysis
Authors: Pozza Andrea , Ferretti Fabio , Coluccia Anna 
Published: June 2019

IntroductionObsessive-compulsive disorder (OCD) is a mental health condition associated with severe impairment in a variety of quality of life domains, an increased physical health burden, and a higher risk of general medical conditions and mortality compared with the general population. While there is a large amount of literature on psychological quality of life, a systematic review of perceived physical health in OCD is lacking. A quantitative summary might suggest that policy makers also focus the evaluation on perceived physical health and develop new strategies also aimed at this outcome. The current paper presents a protocol for the first systematic review and meta-analysis aimed at summarising perceived physical health in OCD by specifically examining perceived physical health status, bodily pain and role limitations due to physical problems in patients with OCD compared with controls. The review will also investigate potential demographic and clinical moderators of perceived physical health status (age, gender, OCD severity, publication date, methodological quality).Methods and analysisA systematic review and meta-analysis will be conducted according to PRISMA guidelines. Studies will be included if using a clinical group with a current primary diagnosis of OCD established by international standardised criteria, if measuring perceived physical health status, and if using screened or community participants as controls. No publication date or language restriction will be applied. An online systematic search of electronic databases (Scopus, PubMed, PsycINFO, EMBASE, Cochrane Library), and examination of conference proceedings and theses/dissertations will be conducted by independent reviewers. Risk of bias will be assessed through the Newcastle-Ottawa Scale.Ethics and disseminationThe current review does not require ethics approval. The results will be disseminated through publications in peer-reviewed journals.PROSPERO registration number2018 CRD42018106194.
Why do trainees leave hospital-based specialty training? A nationwide survey study investigating factors involved in attrition and subsequent career choices in the Netherlands
Authors: Bustraan Jacqueline , Dijkhuizen Kirsten , Velthuis Sophie , van der Post Rachel , Driessen Erik , van Lith Jan M M , de Beaufort Arnout Jan 
Published: June 2019

ObjectiveTo gain insight into factors involved in attrition from hospital-based medical specialty training and future career plans of trainees who prematurely left their specialty training programme.DesignNationwide online survey study.SettingPostgraduate education of all hospital-based specialties in the Netherlands.Participants174 trainees who prematurely left hospital-based medical specialty training between January 2014 and September 2017.Main outcome measuresFactors involved in trainees’ decisions to leave specialty training and their subsequent career plans.ResultsThe response rate was 38%. Of the responders, 25% left their programme in the first training year, 50% in year 2–3 and 25% in year 4–6. The most frequently reported factors involved in attrition were: work-life balance, job content, workload and specialty culture. Of the leaving trainees, 66% switched to another specialty training programme, of whom two-thirds chose a non-hospital-based training programme. Twelve per cent continued their career in a non-clinical role and the remainder had no specific plans yet.ConclusionsThis study provides insight in factors involved in attrition and in future career paths. Based on our findings, possible interventions to reduce attrition are: (1) enable candidates to develop a realistic view on job characteristics and demands, prior to application; (2) provide individual guidance during specialty training, with emphasis on work-life balance and fit with specialty.
Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice
Authors: Espinoza-Derout Jorge , Hasan Kamrul M. , Shao Xuesi M. , Jordan Maria C. , Sims Carl , Lee Desean L. , Sinha Satyesh , Simmons Zena , Mtume Norma , Liu Yanjun , Roos Kenneth P. , Sinha-Hikim Amiya P. , Friedman Theodore C. 
Published: June 2019

Electronic cigarettes (e-cigarettes), also known as electronic nicotine delivery systems, are a popular alternative to conventional nicotine cigarettes, both among smokers and those who have never smoked. In spite of the widespread use of e-cigarettes and the proposed detrimental cardiac and atherosclerotic effects of nicotine, the effects of e-cigarettes on these systems are not known. In this study, we investigated the cardiovascular and cardiac effects of e-cigarettes with and without nicotine in apolipoprotein-E knockout (ApoE−/−) mice. We developed an e-cigarette exposure model that delivers nicotine in a manner similar to that of human e-cigarettes users. Using commercially available e-cigarettes, bluCig PLUS, ApoE−/− mice were exposed to saline, e-cigarette without nicotine [e-cigarette (0%)], and e-cigarette with 2.4% nicotine [e-cigarette (2.4%)] aerosol for 12 wk. Echocardiographic data show that mice treated with e-cigarette (2.4%) had decreased left ventricular fractional shortening and ejection fraction compared with e-cigarette (0%) and saline. Ventricular transcriptomic analysis revealed changes in genes associated with metabolism, circadian rhythm, and inflammation in e-cigarette (2.4%)-treated ApoE−/− mice. Transmission electron microscopy revealed that cardiomyocytes of mice treated with e-cigarette (2.4%) exhibited ultrastructural abnormalities indicative of cardiomyopathy. Additionally, we observed increased oxidative stress and mitochondrial DNA mutations in mice treated with e-cigarette (2.4%). ApoE−/− mice on e-cigarette (2.4%) had also increased atherosclerotic lesions compared with saline aerosol-treated mice. These results demonstrate adverse effects of e-cigarettes on cardiac function in mice. NEW & NOTEWORTHY The present study is the first to show that mice exposed to nicotine electronic cigarettes (e-cigarettes) have decreased cardiac fractional shortening and ejection fraction in comparison with controls. RNA-seq analysis reveals a proinflammatory phenotype induced by e-cigarettes with nicotine. We also found increased atherosclerosis in the aortic root of mice treated with e-cigarettes with nicotine. Our results show that e-cigarettes with nicotine lead to detrimental effects on the heart that should serve as a warning to e-cigarette users and agencies that regulate them.
Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma
Authors: Eberle-Singh Jaime A. , Sagalovskiy Irina , Maurer H. Carlo , Sastra Stephen A. , Palermo Carmine F. , Decker Amanda R. , Kim Min Jung , Sheedy Josephine , Mollin Anna , Cao Liangxian , Hu Jianhua , Branstrom Arthur , Weetall Marla , Olive Kenneth P. 
Published: June 2019

Abstract

Purpose:
Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer that is broadly chemoresistant, due in part to biophysical properties of tumor stroma, which serves as a barrier to drug delivery for most classical chemotherapeutic drugs. The goal of this work is to evaluate the preclinical efficacy and mechanisms of PTC596, a novel agent with potent anticancer properties in vitro and desirable pharmacologic properties in vivo.
Experimental Design: We assessed the pharmacology, mechanism, and preclinical efficacy of PTC596 in combination with standards of care, using multiple preclinical models of PDA.

Results:
We found that PTC596 has pharmacologic properties that overcome the barrier to drug delivery in PDA, including a long circulating half-life, lack of P-glycoprotein substrate activity, and high systemic tolerability. We also found that PTC596 combined synergistically with standard clinical regimens to improve efficacy in multiple model systems, including the chemoresistant genetically engineered “KPC” model of PDA. Through mechanistic studies, we learned that PTC596 functions as a direct microtubule polymerization inhibitor, yet a prior clinical trial found that it lacks peripheral neurotoxicity, in contrast to other such agents. Strikingly, we found that PTC596 synergized with the standard clinical backbone regimen gemcitabine/nab-paclitaxel, yielding potent, durable regressions in a PDX model. Moreover, similar efficacy was achieved in combination with nab-paclitaxel alone, highlighting a specific synergistic interaction between two different microtubule-targeted agents in the setting of pancreatic ductal adenocarcinoma.

Conclusions:
These data demonstrate clear rationale for the development of PTC596 in combination with standard-of-care chemotherapy for PDA.