bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the level of anxiety-depressive disorders, quality of life, and therapy adherence in patients with plaque psoriasis
Authors: Khokhlov A. L. , Samarina E. I. , Lileeva E. G. 
Published: December 2024

Relevance. The treatment of moderate and severe psoriasis poses significant challenges in clinical practice. This article is devoted to the analysis of real-world clinical practice in the treatment of plaque psoriasis, factors causing relapses of plaque psoriasis, the prevalence of anxiety and depressive disorders, and the assessment of the quality of life of patients with psoriasis using various systemic medications among patients who were observed in dermatovenereological dispensaries of the Central Federal District during the period 2022–2023.Objectives. To determine the optimal drug therapy for patients with plaque psoriasis based on comprehensive pharmacoepidemiological, clinical, compliance, and medication adherence assessments.Materials and methods. Retrospective comparative analysis of the medical records of 336 patients with plaque psoriasis (L40.0), moderate and severe. Two comparison groups: Group I — 166 patients receiving methotrexate and Group II — 170 patients receiving genetically engineered drugs. Patients were surveyed by physicians to confirm their therapy compliance. The levels of anxiety and depression were assessed using the HADS scale, and quality of life was assessed using the dermatological quality of life index — DLQI.Results. The highest rate of adherence to therapy (>80%) was recorded in the group of patients undergoing therapy with genetically engineered drugs and who had a high level of anxiety (r=0.202, p<0.05). In the group of patients with average adherence to the applied genetic engineering therapy (30–80%), a higher level of anxiety was associated with reduced adherence to treatment (r=–0.202, p<0.05). Average adherence to methotrexate (r =–0.249, p<0.05).Conclusions. An increased level of anxiety in patients undergoing therapy with genetically engineered drugs increased their adherence to treatment (r=0.202, p<0.05). The worse the quality of life of patients undergoing therapy with genetically engineered drugs, the less adherence.
Some features of statistical analysis of spontaneous adverse drug reporting data
Authors: Bondareva I. B. , Zyryanov S. K. , Asetskaya I. L. , Terekhina E. N. 
Published: December 2024

Introduction. Risk of adverse drug reactions (ADRs) is a serious issue in pharmacotherapy and a major public health concern. Safety signal detection during the post-marketing phase is one of the most important goals of drug safety surveillance. Spontaneous reporting systems (SRS) are still widely used to identify safety signals based on real-world data. Various data mining statistical methods have been developed for this purpose, and they are classified into frequentist and Bayesian approaches. Statistical methods can also be used for the analysis of patient-related risk factors (demographic characteristics, concomitant diseases or medications). Identification of patients at high ADR risk is important for personalized pharmacotherapy.Objective. To present and review issues and features of the statistical methods for SRS data, developed by other authors and published in the literature, this tool may be useful for appropriate statistical analysis and accurate interpretation of passive surveillance data.Methods. In this paper, we present the known and commonly used frequentist or classical methods for correct statistical analysis of spontaneous reports. These methods for signal detection and their modification for drug-host factor interaction analysis are relatively easy to understand, interpret, and compute based on the contingency 2x2 tables: reporting odds ratio (ROR), proportional reporting ratio (PRR), and normal approximation test. Different approaches to the multiple comparison problem in passive safety surveillance settings were also discussed.Results. As an example, the aforementioned methods were applied to analyze sex disparities in liver toxicity based on the spontaneous reports extracted from the Russian National Pharmacovigilance database. The tests identified drugs for which liver toxicity demonstrates significant disproportionality regarding sex compared with other AEs. The results of all statistical methods were similar.Conclusions. Although spontaneous report databases are subject to numerous potential sources of bias and well-known limitations, these large-scale databases remain a widely used, effective, and relatively inexpensive approach for post-marketed drug surveillance. With the use of correct statistical methods, spontaneous reporting databases can provide valuable information for hypothesis generation, which should be investigated further, as well as essential data on the evaluation of risk factors and risk populations.
Cytochrome СYP2C19 gene polymorphisms and bleeding in patients treated with clopidogrel as part of dual antithrombotic therapy after acute coronary syndrome
Authors: Kochetkov A. I. , De V. A. , Batyukina S. V. , Abdullaev Sh. P. , Tuchkova S. N. , Klepikova M. V. , Ostroumova O. D. , Mirzaev K. B. , Sychev D. A. 
Published: December 2024

Relevance. The advantages of using clopidogrel for the treatment of atherosclerotic cardiovascular diseases have been demonstrated in many studies. However, the risk of clinically significant bleeding is increased when clopidogrel is used in combination with other drugs.Objective. To investigate the possible relationship between the carriage of CYP2C19 loss-of-function and gain-of-function alleles and bleeding events in patients with coronary heart disease (CHD) ± atrial fibrillation (AF) receiving dual antithrombotic therapy with clopidogrel after acute coronary syndrome (ACS).Materials and methods. A total of 150 patients (median age 65 [60,75;73] years) were studied, including 77 patients with CHD without AF taking clopidogrel + acetylsalicylic acid; and 73 patients with CHD and AF taking clopidogrel + rivaroxaban or apixaban. DNA samples obtained from all patients were genotyped for CYP2C19 rs4244285, rs4986893, and rs12248560. The follow-up period was 16 weeks ± 1 days. Information about bleeding events was obtained using the MCMDM-1 questionnaire.Results. Bleeding occurred in 26 (17.3%) patients. The most common bleeding events were nosebleeds (42.3%), bruises (30.8%), and oral bleeding (26.9%). Among patients with bleeding events compared with those who did not, carriers of the rs12248560 (CYP2C19*17) TT genotype were significantly more common — 19.2% and 3.2%, respectively (p = 0.008). A similar result was obtained in the CHD group without AF (21.4% vs. 3.2%, respectively, p = 0.039). Among patients in the presence of bleeding, ultrarapid metabolizers (*17/*17) were administered significantly more frequently than those without bleeding (p=0.008).Conclusion. Carriage of the rs12248560 (*17) TT genotype and ultrarapid metabolizers (*17/*17) phenotype were associated with hemorrhagic events in patients with ACS receiving dual antithrombotic therapy with clopidogrel.
Features of indicators of macrohemodynamics and systemic inflammation in patients with community-acquired pneumonia combined with gastroesophageal reflux disease
Authors: Bisov A. S. , Pobedennaya G. P. 
Published: December 2024

Relevance. The clinical course, treatment approaches, and outcomes of community-acquired pneumonia (CAP) often depend on microcirculatory disorders. The significant prevalence of gastroesophageal reflux disease (GERD) in the population determines the frequency of CAP. Study of the pathogenetic basis of the combined course of CAP in individuals with GERD, incl. microcirculation systems, can target correction paths and increase the effectiveness of therapy.Objective. To identify indicators of systemic inflammation and macrohemodynamics in patients with CAP combined with GERD.Material and methods. A total of 123 patients were under observation, incl. with mild CAP without signs of GERD (group I) — 38, with CAP and GERD — 49 (group 2), and 36 patients with GERD without CAP — group 3. In all patients with CAP, along with traditional studies, the concentrations of C-reactive protein (CRP) and brain natriuretic peptide (BNP) were determined in the blood, and echocardioscopy (EchoCS) was performed to determine the end systolic (ES) and diastolic (ED) volumes of the left ventricle (LV) and right ventricles (RV), blood flow velocity at the level of the pulmonary artery (Vmax PA), pressure gradients ΔPmax at the level of the tricuspid valve (TV), PA, and LV isovolumic relaxation time (IVRT). Control values for indicators were obtained from 34 practically healthy donors.Results. In all patients with CAP, at the beginning of therapy, intoxication and respiratory syndromes were observed, and pneumonia was diagnosed on an X-ray. Patients in groups II and III had characteristic symptoms of GERD. Blood tests revealed leukocytosis in all patients with CAP. The initial CRP concentration in group 1 was 5.2, group 2 — 7.7, group 3 — 1.2 times higher than normal. The initial concentration of BNP in all groups did not differ from the control. By discharge, CRP levels in all patients had decreased: however, in group II, they remained higher than in healthy people (2.6 times (p < 0.05) and higher than in group I, 1.3 times (p < 0.05). Before discharge, the BNP level in group II increased by 1.2 times compared with baseline in group I, in healthy individuals, and in group III. When analyzing the EchoCS indicators in group II patients, a significant increase in the initial indicators of LV EDV and LV ESV and decrease in EF and IVRT were observed. After treatment, no significant dynamics of volume and velocity parameters were observed in patients in group II; in patients in group I, pressure gradients at the TC and PA levels remained slightly reduced.Conclusions. An increase in CRP levels in patients with GERD characterizes low-intensity inflammation, which potentiates systemic inflammation in patients with CAP combined with GERD and is accompanied by an increase in BNP.
Bacteriophage therapy and prevention of infectious and inflammatory complications after endoscopic urologic surgery
Authors: Malova Yu. A. 
Published: December 2024

Relevance. Given the growing antibiotic resistance of pathogens of urologic infection to antimicrobial drugs, one of the urgent problems is the search for alternative methods of antimicrobial prevention of infectious and inflammatory complications after surgical interventions, as well as an adequate therapy regimen during the postoperative period. Bacteriophage preparation is an alternative method for the treatment and prevention of infectious and inflammatory urological diseases.Objective. To determine an effective method for preoperative antimicrobial prevention of infectious and inflammatory complications in patients with kidney stones subjected to percutaneous nephrolithotripsy (PNLT).Methods. The study included 90 patients with coralloid or multiple large kidney stones who underwent PNLT. Before PNLT, all patients underwent bacteriological urinalysis in order to determine sensitivity not only to antibiotics and bacteriophage preparations. Urine sampling was performed for further microbiological cultural examination during renal pelvic puncture on the 3rd and 7th days after PNLT. Depending on the technique of perioperative prophylaxis, three groups of 30 were formed. Group 1 patients were intravenously injected with 1000 mg of ciprofloxacin throughout the operation and then intravenously dipped with 1000 mg once a day for 3–5 days. Group 2 received intramuscular cefotaxime + sulbactam (1.0+0.5) twice a day 2 h before surgery intramuscularly once. In group 3, patients received oral mycobacteriophage 40 ml polyvalent purified orally 1 h before surgery and 40 ml orally 3 times a day for 3–5 days after surgery.Results. In all three groups, the development of infectious complications in patients was assessed: acute pyelonephritis, systemic inflammatory reaction syndrome (SERS) or urosepsis. No serious infectious or inflammatory complications were observed in any group during the early postoperative period. The development of CVD after PNLT was noted on the 1st–3rd postoperative day (in 26.6 %, 20 and 20 % of patients of the 1st, 2nd and 3rd groups, respectively). However, on the 4th–7th day after PNLT, normal blood parameters (leukocytes, rod-shaped neutrophils), temperature, and general well-being were noted.Conclusion. The same effectiveness of different antimicrobial regimens for preventing infectious and inflammatory complications after PNLT was similar. Bacteriophage preparations are effective and can prevent infectious and inflammatory complications following PNLT. The development of CVD after PNLT on the 1st–3rd day after surgery cannot be correlated only with the antimicrobial drugs used and the method of their administration (intravenously, intramuscularly and orally). Most likely, the development of CVD is associated with operational injury.
A new genus of the family Mycetophagidae (Coleoptera) from Eocene Danish amber
Authors: Legalov Andrei A. , Vasilenko Dmitry V. , Perkovsky Evgeny E. 
Published: December 2024

Aggerbille havai gen. et sp. nov. is described from late Eocene Danish amber. The new genus differs from the genus Triphyllus Dejean, 1821 by antennomeres 9 and 10 longer than wide, pronotum more strongly narrowed toward the apex, and shorter elytra; from the genus Neotriphyllus Lawrence et al., 2014 by its smaller body size, pronotum more strongly narrowed towards the apex, mesoventrite flattened, and its body covered with dark, long, decumbent setae. It is distinguished from the genus Litargus Erichson, 1846 by its posterior pronotal angles obtuse and not embracing the elytral humeri. Aggerbille differs from the genus Crowsonium Abdullah, 1964 by its pronotum being broadest at the base and by its distinct antennal club consisting of three segments. This is the first named Mycetophagidae from late Eocene Danish amber.
Numerical Simulation on Flow and Heat Transfer Characteristics of a Single-loop Oscillating Heat Pipe with Variable Pipe Diameter Ratios
Authors: Lu Hongkun , Mat Noor Muhamad , Shuigen Ning , Kadirgama Kumaran 
Published: December 2024

A three-dimensional numerical model, employing the Volume of Fluid (VOF) method, was developed for a single-loop oscillating heat pipe (OHP) with variable diameters. The investigation explored the impact of varying pipe diameter ratios on flow and heat transfer characteristics at different operational stages under a 40W heat power. The results reveal that the diameter ratio significantly affects the spatial arrangement of the evaporation, adiabatic, and condensation sections in the OHP. In the initial stage, the condensation section displays 15 liquid slugs when the diameter ratio is 1, but this number decreases to fewer than 10 in the same area when the diameter ratio exceeds 1. Comparative to a straight-pipe OHP, configurations with varying diameter ratios exhibit a marginal reduction in the average fluid velocity during the circulation of the working fluid inside the pipe, with the most pronounced velocity decrease occurring at a diameter ratio of 0.8. As the diameter ratio increases to 1.25 and 1.5, the turbulent disturbances in the region where the working fluid flows from the adiabatic section to the evaporation or condensation section intensify, facilitating the temperature exchange within the OHP. During stable operation of the OHP, the frequency of temperature oscillations increases with an increasing diameter ratio, while the amplitude decreases. Among all the cases, the OHP with a diameter ratio of 1.25 has the optimal heat resistance, 1.50K/W. The heat transfer performance of the OHP with a pipe diameter ratio of 0.8 deteriorated, and the thermal resistance increased by 27.6% compared with the straight-pipe OHP.
PENGARUH BAURAN PEMASARAN 4P TERHADAP MINAT BELI IKAN KERING DI UKM KELURAHAN OESAPA KOTA KUPANG
Authors: Bulan Melkianus Teddison , Amil Patricia Ardia , Sri Naharuddin 
Published: December 2024

This study aimed to analyze the effect of the 4P marketing mix on buying interest in dried fish at UKM Bahar in Oesapa village. The type of research used in this study was quantitative. The population was all consumers who had bought fish at UKM Bahar in Oesapa village at least twice and had an age range of 17–50 years with accidental sampling, and the total sample was 68 people. The data analysis was multiple linear regression. The findings showed that product and promotion variables had a negative and significant effect on consumer buying in­terest, price, and placed variables had a positive and significant impact on con­sumer buying interest, and product variables had a dominant effect on consumer buying interest in dried fish at UKM Bahar in Oesapa village. The implications of this study provided direction for SMEs in Bahar Oesapa village to pay attention to product and promotion factors because both factors negatively influenced consu­mer buying interest. After all, it indicates that the decreasing quality of products and promotions reduced consumer buying interest, so there will be an increase in sales in the future. Penelitian ini bertujuan untuk menganalisis pengaruh bauran pemasaran 4P pada minat beli ikan kering di UKM Bahar kelurahan Oesapa. Jenis penelitian yang digunakan dalam penelitian ini adalah kuantitatif. Populasi dalam penelitian adalah semua konsumen yang pernah membeli ikan di UKM Bahar kelurahan Oesapa minimal dua kali dan memiliki kisaran umur 17–50 tahun dengan pengambilan sampel accidental sampling dan total sampel yang digunakan dalam penelitian ada­lah 68 orang. Analisis data yang digunakan adalah regresi linear berganda. Hasil temuan menunjukkan bahwa variabel produk dan promosi berpengaruh negatif dan signifikan pada minat beli konsumen, vari­abel harga dan tempat berpengaruh positif dan signifikan pada minat beli konsumen, dan variabel produk dominan berpengaruh pada minat beli konsumen ikan kering di UKM Bahar keluraharan Oesapa. Implikasi pe­ne­li­ti­an ini mem­be­ri­kan arahan bagi pihak UKM Bahar kelurahan Oesapa untuk memperhatikan faktor produk dan promosi sebab kedua faktor tersebut memiliki pengaruh negatif terhadap minat beli konsumen karena mengindikasikan bahwa semakin menurunnya kualitas produk dan promosi, maka menurunkan minat beli konsumen, sehingga di masa yang akan datang ada peningkatan penjualan.
Association of the Apollo Wearable With Fatigue, Raynaud Phenomenon, and Quality of Life in Patients With Systemic Sclerosis: A Pilot Study
Authors: Hammaker Krista , Hu Haomin , Laffoon Maureen , Freno Leigh A. , Lafyatis Robert , Park Yongseok , Domsic Robyn T. 
Published: December 2024

ObjectiveIn patients with systemic sclerosis (SSc), fatigue is the highest-ranked symptom affecting quality of life (QOL), followed by Raynaud phenomenon (RP). We report results from a pilot study of the Apollo wearable device in patients with SSc.MethodsTwenty-five adult participants with SSc, moderate fatigue, and RP were enrolled. Participants completed a 4-week intervention, during which they wore the Apollo device daily for a minimum of 15 minutes. The primary outcome was change on the Patient Reported Outcomes Measurement Information System Fatigue 13a (PROMIS Fatigue) at 4 weeks.ResultsAfter 4 weeks of using the Apollo wearable, participants reported less fatigue on the PROMIS Fatigue (P< 0.001) scale. The average daily number of RP attacks declined (P= 0.007), as did the Raynaud Condition Score (P= 0.007) after 4 weeks of use. Average device usage (2.87 hours/day) far exceeded the requested time, and no adverse events occurred. The PROMIS-29 subscores assessment demonstrated QOL improvement in physical function (P= 0.01), depression (P= 0.03), fatigue (P= 0.01), sleep disturbance (P= 0.002), and ability to participate in social roles and activities (P< 0.001). Significant improvements were also noted for depression (P= 0.004) and disability (P< 0.05) measures.ConclusionUse of the Apollo wearable for 4 weeks was associated with improvement in fatigue and RP symptoms in patients with SSc, with improved QOL measures, lower depression scores, and improved disability measures. Future studies should further test the efficacy of the Apollo wearable in these domains and QOL of patients with SSc. (ClinicalTrials.gov:NCT04854850)
Tocilizumab (TCZ) for Giant Cell Arteritis: Clinical Outcomes Following Relapses and TCZ Discontinuation Due to Adverse Events
Authors: Nagase Fumika N. , Fukui Sho , Takizawa Naoho , Yamaguchi Toshihiro , Oda Nobuhiro , Inokuchi Hajime , Ito Takanori , Watanabe Mitsuru , Suda Masei , Haji Yoichiro , Suyama Yasuhiro , Rokutanda Ryo , Minoda Masahiro , Nomura Atsushi , Uechi Eishi , Tamaki Hiromichi 
Published: December 2024

ObjectiveTocilizumab (TCZ) is effective for giant cell arteritis (GCA). However, little is known regarding treatment modification and clinical outcomes after unfavorable events such as GCA relapses or TCZ discontinuation due to adverse events (AEs).MethodsThis multicenter retrospective study included patients with GCA who initiated TCZ from 2008 to 2021 at 5 Japanese hospitals. GCA relapses and TCZ-related AEs were monitored for 2 years after TCZ initiation. In patients with GCA relapses, subsequent clinical courses, including relapse symptoms and treatment modification, were followed for 90 days after the relapses. Similarly, patients who discontinued TCZ because of AEs were additionally followed until 1 year after the TCZ discontinuation to evaluate AEs, relapses, and treatment changes.ResultsOf 62 eligible patients, 10 patients (16%) relapsed after initiating TCZ therapy. Most relapses (8 of 10) occurred after extending TCZ intervals or discontinuing TCZ. Combinations of adjusting TCZ intervals, adjusting glucocorticoid (GC) dose, and/or adding or increasing methotrexate (MTX) therapy could manage the relapses without serious complications. In the entire cohort, AEs occurred in 28 patients (45%), and 8 patients (13%) discontinued TCZ because of AEs. After AE-related TCZ discontinuation, 6 patients attempted to taper GCs without other immunosuppressive therapy (IST), and 4 subsequently relapsed. In contrast, 2 patients who used other IST or biologic therapy could decrease GCs without relapses.ConclusionAlthough GCA relapses can occur after initiating TCZ therapy, most relapses can be safely managed by adjusting TCZ, GC, and/or MTX doses. Adding IST or biologic treatments may potentially be related to preventing relapses when patients discontinue TCZ because of AEs.