bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluvial sedimentary history of Arlington Canyon, Channel Islands National Park, California
Authors: Schumann R. Randall , Pigati Jeffrey S. 
Published: July 2019

ABSTRACTArlington Canyon, in the northwest part of Santa Rosa Island, Channel Islands National Park, California, has been the setting for important scientific discoveries over the past half century, including the oldest human remains in North America, several vertebrate fossil sites, and purported evidence of a catastrophic extinction event at the end of the Pleistocene. The canyon is filled with alluvial sediments that date to between 16.4 and 1.1 ka (thousands of calibrated years before present), representing accumulation that occurred primarily in response to rising sea levels during the late Pleistocene and Holocene. The deposits are laterally discontinuous, exhibit a high degree of sedimentary complexity, and contain evidence of past climates and environments, including fossil bones, burned plant macrofossils, and invertebrate microfossils. Here, we show that it is critical to view the observations, data, and conclusions of scientific studies conducted in the canyon within this larger context so that localized facets of the spatially and temporally extensive alluvial deposits are not misinterpreted or misrepresented. By improving the baseline understanding of processes and drivers of sediment accumulation in Arlington Canyon, we hope to offer a solid foundation and better underpinning for future archeological, paleontological, and geochemical studies here and throughout the northern Channel Islands. Published 2019. This article is a U.S. Government work and is in the public domain in the USA.
MetaInsight: An interactive web‐based tool for analyzing, interrogating, and visualizing network meta‐analyses using R‐shiny and netmeta
Authors: Owen Rhiannon K. , Bradbury Naomi , Xin Yiqiao , Cooper Nicola , Sutton Alex 
Published: July 2019

BackgroundNetwork meta‐analysis (NMA) is a powerful analysis method used to identify the best treatments for a condition and is used extensively by health care decision makers. Although software routines exist for conducting NMA, they require considerable statistical programming expertise to use, which limits the number of researchers able to conduct such analyses.ObjectivesTo develop a web‐based tool allowing users with only standard internet browser software to be able to conduct NMAs using an intuitive “point and click” interface and present the results using visual plots.MethodsUsing the existing netmeta and Shiny packages for R to conduct the analyses, and to develop the user interface, we created the MetaInsight tool which is freely available to use via the web.ResultsA package was created for conducting NMA which satisfied our objectives, and this is described, and its application demonstrated, using an illustrative example.ConclusionsWe believe that many researchers will find our package helpful for facilitating NMA as well as allowing decision makers to scrutinize presented results visually and in real time. This will impact on the relevance of statistical analyses for health care decision making and sustainably increase capacity by empowering informed nonspecialists to be able to conduct more clinically relevant reviews. It is also hoped that others will be inspired to create similar tools for other advanced specialist analyses methods using the freely available technologies we have adopted.
Phosphate‐solubilizing bacteria improveAgave angustifoliaHaw. growth under field conditions
Authors: Bautista‐Cruz Angélica , Antonio‐Revuelta Betsy , del Carmen Martínez Gallegos Verónica , Báez‐Pérez Aurelio 
Published: July 2019

AbstractBACKGROUNDPhosphate‐solubilizing bacteria (PSB) can be an environment‐friendly strategy to improve crop production in low‐phosphorus (P) or P‐deficient soils. The effect of indigenous mixed inocula of PSB onAgave angustifoliaHaw. growth was assessed. The four treatments evaluated were T1 (Pseudomonas luteola + Enterobactersp.), T2 (Pseudomonas luteola + Bacillussp.), T3 (Pseudomonas luteola + Acinetobactersp.), and T4 (control); each was replicated 25 times using a completely randomized design during 12 months under rain‐fed conditions. Additionally, P solubilizationin vitroof the mixed inocula with three different sources of inorganic P was tested.RESULTSThe mixed inocula were able to solubilize more P from tricalcium phosphate Ca3(PO4)2than from aluminum phosphate (AlPO4) and iron phosphate (FePO4). Relative to the control, T2 increased plant height by 22.9%, leaf dry weight by 391.4%, plant stem diameter by 49.6%, and root dry weight by 193.9%. The stem solid soluble content increased 50.0% with T1. Plant‐available soil P increased 94.6% with T3 and 77.3% with T1. Soil alkaline phosphatase activity increased 85.9% with T1.CONCLUSIONT2 was the mixed inoculum that most improvedAgave angustifoliaplant growth. The indigenous mixed inocula of PSB evaluated appears to be a practical and efficient option for promoting field growth ofAgave angustifoliaplants. However, further research is necessary to achieve a deeper understanding of the relationships between different PSB species and their effects on agave, which may reveal some of the mechanisms of the synergistic interactions that are involved in the promotion of plant growth. © 2019 Society of Chemical Industry
A Khorasan wheat‐based diet improves systemic inflammatory profile in semi‐professional basketball players: a randomized crossover pilot study
Authors: Spisni Enzo , Valerii Maria Chiara , De Fazio Luigia , Rotondo Enrica , Di Natale Marcella , Giovanardi Elisabetta , Posabella Giovanni , Bregola Valeria , Stenico Verena , Sferrazza Rocco Enrico , Dinelli Giovanni , Bosi Sara 
Published: July 2019

AbstractBACKGROUND/OBJECTIVESKhorasan wheat is an ancient grain with widely acclaimed beneficial effects on human health. The objective of the study was to examine the effect of a Khorasan‐based diet on the wellbeing and inflammatory profile of young athletes.RESULTSWe conducted a randomized, single‐blinded crossover trial involving 20 male young athletes. The participants were randomly assigned to consume products (pasta, bread, biscuits and crackers) made either with Khorasan (KAMUT® brand) or modern semi‐whole‐grain wheat for 4‐weeks with a 4‐week washout period before the crossover. Laboratory analyses and fitness tests were performed both at the beginning and end of each diet period. The consumption of Khorasan products was associated with a significant reduction of monocyte chemoattractant protein‐1 (MCP‐1; mean reduction: −36.15 pg/mL; −25.67%) while the consumption of modern wheat was not associated with significant differences in Interleukin‐8 (IL‐8) or Interleukin‐1 receptor antagonist (IL‐1ra). The consumption of the Khorasan‐based diet also resulted in a significant improvement in self‐rated health status. No statistically significant differences in any athletic performance parameter were observed between the two diets.CONCLUSIONThe present results suggest that a Khorasan‐based diet could be effective in reducing the inflammatory status in young athletes. © 2019 Society of Chemical Industry
Analysis of Chuanxiong Rhizoma substrate on production of ligustrazine in endophytic Bacillus subtilis by ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry
Authors: Yin Dan Dan , Wang Yun Lai , Yang Mo , Yin Deng Ke , Wang Guo Kai , Xu Fan 
Published: July 2019

AbstractLigustrazine was the active ingredient of the traditional Chinese medicine Chuanxiong Rhizoma. However, the content of ligustrazine is very low. We proposed a hypothesis that ligustrazine was produced by the mutual effects between endophytic Bacillus subtilis and the Ligusticum chuanxiong Hort. This study aimed to explore whether the endophytic B. subtilis LB5 could make use of Chuanxiong Rhizoma fermentation matrix to produce ligustrazine and clarify the mechanisms of action preliminarily. Ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry analysis showed the content of ligustrazine in Chuanxiong Rhizoma was below the detection limit (0.1 ng/mL), while B. subtilis LB5 produced ligustrazine at the yield of 1.0268 mg/mL in the Chuanxiong Rhizoma‐ammonium sulfate fermentation medium. In the fermented matrix, the reducing sugar had a significant reduction from 12.034 to 2.424 mg/mL, and rough protein content increased from 2.239 to 4.361 mg/mL. Acetoin, the biosynthetic precursor of ligustrazine, was generated in the Chuanxiong Rhizoma‐Ammonium sulfate (151.2 mg/mL) fermentation medium. This result showed that the endophytic bacteria B. subtilis LB5 metabolized Chuanxiong Rhizoma via secreted protein to consume the sugar in Chuanxiong Rhizoma to produce a considerable amount of ligustrazine. Collectively, our preliminary research suggested that ligustrazine was the interaction product of endophyte, but not the secondary metabolite of Chuanxiong Rhizoma itself.
Evaluation of selected buffers for simultaneous determination of ionic and acidic pesticides including glyphosate using anion exchange chromatography with mass spectrometric detection
Authors: Jansons Martins , Pugajeva Iveta , Bartkevics Vadims 
Published: July 2019

AbstractIon chromatography coupled with mass spectrometry is an established technique for determination of ionic analytes, however, sophisticated buffer removal equipment is required to eliminate inorganic compounds from the eluate before introduction into the ion source of mass spectrometer. A standard high‐performance liquid chromatography coupled with tandem mass spectrometry setup using an ion exchange column (Metrosep® A Supp 5) is proposed as an alternative approach. For that reason, some buffers including non‐volatile carboxylic acid based solutions have been evaluated for simultaneous trace determination of ionic and acidic pesticides including glyphosate in the same extract without a need for sophisticated buffer removal equipment. Two differently designed ionisation sources were compared qualitatively for the application of non‐volatile buffers. The study revealed that the choice of buffers had a strong influence on matrix effects in case of spiked extract injections. Finally, pesticides with very different physicochemical properties (logP < 0, logP ≥ 0) and structures (containing carboxylate, phosphonate, azolide, azanide, phenolate, bromate, and chlorate moieties) were quantified in spiked beer and oat extracts with acceptable recoveries (80–110%) using tandem mass spectrometry detection with AB SCIEX QTRAP 5500 instrument after separation using edetate buffer.
Laser Ablation of Benign Thyroid Nodules: A Prospective Pilot Study With a Preliminary Analysis of the Employed Energy
Authors: de Freitas Ricardo Miguel Costa , Miazaki Aline Paterno , Tsunemi Miriam Harumi , de Araujo Filho Vergilius José Furtado , Marui Suemi , Danilovic Debora Lucia Seguro , Buchpiguel Carlos Alberto , Chammas Maria Cristina 
Published: July 2019

Background and ObjectivesTo assess the effectiveness of ultrasound (US)‐guided laser ablation of benign thyroid nodules (TNs) under different amounts of applied energy.Study Design/Materials and MethodsThirty‐four euthyroid patients with 5–18 ml TNs were enrolled: 21 (laser ablation) and 13 (clinical follow up) patients with a mean age of 56.2 ± 12.0 and 54.7 ± 14.7 years, respectively. The laser ablation protocol used a 1.064 mm wavelength diode laser source; 3.5 W output power; 1,100–1,500 J and 5–8 min/illumination; and one or two fibers/session. Clinical, laboratory, and US data were obtained immediately before treatment and at 6 and 12 months follow‐up and were analyzed by Student's
t test and Fisher's exact test. Low‐ and high‐energy subgroups were subsequently defined, and the receiver operating characteristic (ROC) curves were calculated.ResultsLaser ablation follow‐up showed an overall nodule volume reduction of more than 50%; improvement of symptoms and cosmetic complaints (P = 0.001); and stable laboratory data compared with the baseline and control groups. Minor complications were 9.5% (
n = 2). One or two fibers/session resulted in a similar nodule volume reduction among 10–18 ml nodules. Analysis of the applied energy suggested a 398.8 J/ml inferior cutoff (ROC curve: 0.889 sensitivity; 0.545 specificity) for the high‐energy subgroup (
n = 14, mean 599.9 ± 136.5 J/ml) to reduce the nodule volume over time (−55.1% vs. −58.4%,
P = 0.55). The low‐energy subgroup (
n = 7, mean 240.2 ± 74.6 J/ml) did not show a persistent volume reduction (
P < 0.05) from the 6‐ to 12‐month follow‐ups (−56.6% vs. −53.7%).ConclusionsLaser ablation of benign TNs achieved technique efficacy at 12 months posttreatment, with clinical improvement and few minor side effects. A single fiber in a single session with a high deployed energy (>398.8 J/ml) may be associated with improved results, a finding to be confirmed with a larger series. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.
Stretchable and Designable Textile Pattern Strain Sensors Based on Graphene Decorated Conductive Nylon Filaments
Authors: Tian Mingwei , Zhao Renhai , Qu Lijun , Chen Zhihua , Chen Shaojuan , Zhu Shifeng , Song Wenfang , Zhang Xiansheng , Sun Yaning , Fu Ranran 
Published: July 2019

AbstractFlexible sensors with stretchable and wearable characteristics have boosted wide interest in human motion detection and physiological signal monitoring. However, the majority of current sensors suffer from the lack of seamlessly integrated with clothes substrates, hindering their applications as “real” wearable devices. Herein, a facile low‐cost and scalable continuous capillary dip coating route is employed to deposit graphene inks onto nylon filaments to obtain graphene decorated nylon conductive filaments. The filaments exhibit noticeable promotion in electrical conductivity with remarkable laundry durability, and the electrical conductivity of our filaments could be up to 6.43 and 2.78 S m−1 before and after washing 10 times, respectively. Two kinds of conventional textile formation techniques, sewing and knitting, are utilized to form various textile pattern strain sensors from the conductive filaments as the building blocks, such as the linear‐type, knitted‐loop‐type, snail‐coil‐type sewed sensors and the tubular knitted fabric sensors respectively. The textile sensors with different patterns exhibited various sensing response, the knitted‐loop‐type sensor could reach the maximum strain 45.69% while the linear‐type one arrives at 13.64%. In addition, the above strain sensors exhibit high sensitivity and repeatability when monitoring the limb movement and human breathing.
The moderating impact of perceived globalness on consumers’ purchase intentions for copycats: The pleasure of hurting global brands
Authors: Loebnitz Natascha , Grunert Klaus G. 
Published: July 2019

AbstractCopycats or “me‐too” brands imitate prominent features of market leaders with the intention to benefit from consumers’ positive associations of the imitated brand. However, the imitated market leader can be perceived as being local (=in‐group) or global (=out‐group). Employing social identity theory, Study 1 examined the interaction between copycat strategy and perceived globalness of the brand, showing that consumers have higher purchase intentions for global copycats versus a local counterpart. Study 2 shows that the interacting effect of copycat strategy and perceived globalness is moderated by consumer ethnocentrism. Further, authors demonstrate that a global copycat elicit greater schadenfreude (vs. local brand), which in turn increases consumers’ purchase intentions. Subsequent mediation analysis shows that ethnocentric consumers experience schadenfreude upon encountering copycats of global brands, which in turn increases purchase intention, whereas low ethnocentric consumers show higher purchase intentions for local differentiated brands because they deem a copycat strategy as unacceptable. Finally, Study 3 examines whether the results from Studies 1 and 2 continue to hold for theme copycats.
Can we find the right balance in cause‐related marketing? Analyzing the boundaries of balance theory in evaluating brand‐cause partnerships
Authors: Yun Joseph T. , Duff Brittany R. L. , Vargas Patrick , Himelboim Itai , Sundaram Hari 
Published: July 2019

AbstractCause‐related marketing (CRM) refers to the phenomenon where brands partner with causes, such as nonprofit organizations. Consumers may see some CRM partnerships as less compatible than others, however the level of perceived compatibility differs from one consumer to another. We know a great deal about how perceptions of compatibility affect attitude and behavior toward CRM partnerships, but we know less about how to predict a consumer's perception of compatibility. Therefore, our purpose was to investigate the boundaries in which balance theory could be used to make predictions about consumers’ responses to CRM partnerships. This is the first study to consider the construct of attitude strength (vs. attitude alone) when considering balance theory. We found that a consumer's attitude toward a brand, along with their attitude toward a cause, predicts their perceptions of CRM compatibility. We also found that CRM triadic balance could be predicted when attitude strength was included in the models, and that balance theory allowed us to observe preliminary evidence of attitude and attitude strength spillover effects in CRM triads. Practitioners can use these insights to determine which organizations to partner with, as well as determine how advertising these partnerships may affect acceptance of these partnerships.
BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease
Authors: Moussa‐Pacha Nour M. , Abdin Shifaa M. , Omar Hany A. , Alniss Hasan , Al‐Tel Taleb H. 
Published: July 2019

AbstractAlzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no current cure. One of the important therapeutic approaches of AD is the inhibition of β‐site APP cleaving enzyme‐1 (BACE1), which is involved in the rate‐limiting step of the cleavage process of the amyloid precursor protein (APP) leading to the generation of the neurotoxic amyloid β (Aβ) protein after the γ‐secretase completes its function. The produced insoluble Aβ aggregates lead to plaques deposition and neurodegeneration. BACE1 is, therefore, one of the attractive targets for the treatment of AD. This approach led to the development of potent BACE1 inhibitors, many of which were advanced to late stages in clinical trials. Nonetheless, the high failure rate of lead drug candidates targeting BACE1 brought to the forefront the need for finding new targets to uncover the mystery behind AD. In this review, we aim to discuss the most promising classes of BACE1 inhibitors with a description and analysis of their pharmacodynamic and pharmacokinetic parameters, with more focus on the lead drug candidates that reached late stages of clinical trials, such as MK8931, AZD‐3293, JNJ‐54861911, E2609, and CNP520. In addition, the manuscript discusses the safety concerns and insignificant physiological effects, which were highlighted for the most successful BACE1 inhibitors. Furthermore, the review demonstrates with increasing evidence that despite tremendous efforts and promising results conceived with BACE1 inhibitors, the latest studies suggest that their clinical use for treating Alzheimer's disease should be reconsidered. Finally, the review sheds light on alternative therapeutic options for targeting AD.
Two novel GJA1 variants in oculodentodigital dysplasia
Authors: Pace Nikolai P. , Benoit Valerie , Agius David , Grima Maria Angela , Parascandalo Raymond , Hilbert Pascale , Borg Isabella 
Published: July 2019

AbstractBackgroundOculodentodigital dysplasia (ODDD) is a rare disorder with pleiotropic effects involving multiple body systems, caused by mutations in the gap junction protein alpha 1 (GJA1) gene. GJA1 gene encodes a polytopic connexin membrane protein, Cx43, that is a component of connexon membrane channels.MethodsWe describe two unrelated female probands referred for a genetic review in view of a dysmorphic clinical phenotype.ResultsTwo novel missense mutations in GJA1 that substitute conserved amino acids in the first and second transmembrane domains (NM_000165.5: c.77T>C p.Leu26Pro and NM_000165.5:c.287T>G p.Val96Gly) were detected through targeted sequencing of GJA1. These variants were detected in the heterozygous state in the two Maltese probands and segregated with the disease phenotype.ConclusionThis report further expands the mutational spectrum of ODDD.
A De Novo heterozygous frameshift mutation identified in BCL11B causes neurodevelopmental disorder by whole exome sequencing
Authors: Qiao Fengchang , Wang Chen , Luo Chunyu , Wang Yan , Shao Binbin , Tan Jianxin , Hu Ping , Xu Zhengfeng 
Published: July 2019

AbstractBackgroundNext‐generation sequencing has been invaluable to delineate the genetic etiology of neurodevelopmental disorders (NDDs) in recent years. BCL11B, encoding Cys2His2 zinc finger transcription factor, is essential for the development of immune and neural systems.MethodsHerein, we describe a Chinese girl presenting craniofacial abnormalities, developmental delay and intellectual disability with speech impairment. Exomes of genes were enriched with the Agilent SureSelect QXT ALL Human Exon V6 kit and sequenced on Illumina Hiseq 2500 platform.ResultsAfter variants filtering and annotation, we identified a de novo heterozygous 11bp frameshift mutation NM_138576.4: c.2190_2200delGGACGCACGAC (p.Thr730Thrfs*151) in exon 4 of BCL11B, which is expected to escape nonsense‐mediated mRNA decay and probably result in a truncated protein with lack of the C‐terminal DNA‐binding zinc‐finger domains.ConclusionThis is the first report of NDD caused by a BCL11B variant in a Chinese population. The mutation identified in this report broadens the knowledge of mutation spectrum of BCL11B and might help in genetic counseling and reducing reproductive risk.
A novel pathogenic missense variant in CNNM4 underlying Jalili syndrome: Insights from molecular dynamics simulations
Authors: Parveen Asia , Mirza Muhammad U. , Vanmeert Michiel , Akhtar Javed , Bashir Hina , Khan Saadullah , Shehzad Saqib , Froeyen Matheus , Ahmed Wasim , Ansar Muhammad , Wasif Naveed 
Published: July 2019

AbstractBackgroundJalili syndrome (JS) is a rare cone‐rod dystrophy (CRD) associated with amelogenesis imperfecta (AI). The first clinical presentation of JS patients was published in 1988 by Jalili and Smith. Pathogenic mutations in the Cyclin and CBS Domain Divalent Metal Cation Transport Mediator 4 (CNNM4) magnesium transporter protein have been reported as the leading cause of this anomaly.MethodsIn the present study, a clinical and genetic investigation was performed in a consanguineous family of Pakistani origin, showing characteristic features of JS. Sanger sequencing was successfully used to identify the causative variant in CNNM4. Molecular dynamics (MD) simulations were performed to study the effect of amino acid change over CNNM4 protein.ResultsSequence analysis of CNNM4 revealed a novel missense variant (c.1220G>T, p.Arg407Leu) in exon‐1 encoding cystathionine‐β‐synthase (CBS) domain. To comprehend the mutational consequences in the structure, the mutant p.Arg407Leu was modeled together with a previously reported variant (c.1484C>T, p.Thr495Ile) in the same domain. Additionally, docking analysis deciphered the binding mode of the adenosine triphosphate (ATP) cofactor. Furthermore, 60ns MD simulations were carried out on wild type (p.Arg407/p.Thr495) and mutants (p.Arg407Leu/p.Thr495Ile) to understand the structural and energetic changes in protein structure and its dynamic behavior. An evident conformational shift of ATP in the binding site was observed in simulated mutants disrupting the native ATP‐binding mode.ConclusionThe novel identified variant in CNNM4 is the first report from the Pakistani population. Overall, the study is valuable and may give a novel insight into metal transport in visual function and biomineralization.