bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-life results of sofosbuvir based therapy for patients with hepatitis C
Authors: Zhivitsa D. G. , Zhivitsa L. V. , Shynkarenko V. L. , Tsaryova O. V. , Siyanova L. Yu. , Glazunova G. V. 
Published: October 2019

Purpose of the study. The sofosbuvir (SOF) based regimes for the treatment of patients infected with hepatitis C virus (HCV) has improved rates of sustained virological response (SVR) considerably in recent trials. There is only limited data concerning the efficacy and safety in a real-life cohort. We analyzed the treatment outcome of SOF based regimes for chronic hepatitis C patients in a real life setting.
Materials and methods. This retrospective study analyzed 205 patients with chronic HCV infection. The following treatments were given according national guidelines: SOF + pegylated interferon alpha-2b + ribavirin for 12 weeks; SOF + ribavirin for 12–24 weeks.
Results. Among 3 patients withgenotype 1a HCV the SVR12 rate was 100%, among 100 patients with genotype 1bHCV the SVR12 rate was 92%, among 11 patients with genotype 2 HCV the SVR12 rate was 90.9% and among 91 patients with genotype 3a HCV the SVR 12 rate was 96,7%. Treatment was safe, most of the side effects and laboratory abnormalities (anemia, neutropenia) found during this study were associated with pegylated interferon or ribavirin.
Conclusion. In real life setting treatment regimens for chronic hepatitis C patients with SOF based regimens are highly effective and safe, including patients with cirrhosis and treatment experienced patients
Antibiotic prophylaxis of purulent and septical complications during surgical treatment of complicated gallstone disease on background of liver cirrhosis
Authors: Khimich S. D. , Muravyev F. T. 
Published: October 2019

Purpose of the study. The goal of this investigation was to determine the main risk factors in development of purulent and septical complications during surgical treatment of complicated gallstone disease on background of liver cirrhosis.
Materials and methods. We retrospectively reviewed medical records of 247 patients who undergone treatment in minimally invasive surgery centre of Zhytomyr regional clinical hospital during 2009–2018. All patients with complicated gallstone disease were divided in two groups: group 1 – patients with concomitant liver cirrhosis – 79(31,98%), and group 2 – patients without liver cirrhosis – 168 (68,02%). Theinclusion criteria were presents of complicated gallstone disease (acute calculous cholecystitis, choledocholithiasis with obstructive jaundice and Mirizzi syndrome), and verified liver cirrhosis. Patients with oncological history, immunodeficiency and morbid obesity were excluded. Liver cirrhosis was staged by Child-ТurcotteРugh system. In all cases patient’s condition was assessed by APACHE II scoring system and patients with cirrhotic lesion were additionally analyzed by MELD score. Acute calculous cholecystitis was diagnosed in 185 patients: group 1 – 68(Child A – 36, Child B – 31, Child C – 1), group 2 – 117 patients. The signs of cholodecholithiasis with obstructive jaundice were present in 49 cases: group 1 – 7 (Child A – 5, Child B – 1, Child C – 1), group 2 – 42. Mirizzi syndrome was verified in 9 cases: group 1 – 2 (Child A – 1, Child B – 1, group 2 – 7.
Results and discussion. In all patients treatment was started in conservative way that included detoxic, antibacterial and hepatoprotective components. In group of control early operative tactic in cases with acute calculous cholecystitis was preferred. Antimicrobial prophylaxis was performed in cases of severe and moderate calculous cholecystitits with use of cephalosporines of 2 generation in moderate case, and protected cephalosporines of 3 generation in combination with metronidazol in severe. In main group providing of antimicrobial therapy was performed very carefully, because of higher risk of hepato-renal insufficiency. The early de-escalation therapy was mandatory performed. Purulent complications occurred in 13,2% of patient with liver cirrhosis in comparison with control group with 1,7% of complications.
Conclusion. The treatment of complicated gallstone disease in patients with liver cirrhosis is very risky in case of postoperative purulent complications. In case of Child A stage of cirrhosis the treatment is safe, and the incidents of purulent complications is the same like in the absence of cirrhosis. Administration of antibiotics in cirrhotic should be very careful because of higher risk of hepato-renal insufficiency. The early de-escalation therapy should be mandatory performed. The «gold» standard of empirical antimicrobial therapy is the use of cephalosporines of 2 and 3 generation.
TECİL MÜESSESESİNİN 6183 SAYILI KANUNA HÂKİM OLAN İLKELER AÇISINDAN DEĞERLENDİRİLMESİ
Authors: COŞKUN KARADAĞ Neslihan , KARABUĞA Fatih 
Published: October 2019

Tecil kamu alacaklarının tahsilini düzenleyen 6183
sayılı Kanunun önemli kurumlarından birisidir. Kamu alacaklarının tahsilinde
“çok zor durumda” bulunan kamu borçlusuna borcunu erteleme ve taksitlendirme imkânı
veren tecil müessesesi bu yönüyle borçluya ödeme kolaylığı sağlarken, alacaklı kurumun ise vadenin belirli bir süre
ertelenmesi ile alacağın tahsili ve gelir kaynağının devamlılığını sağlamasına
yardımcı olur. Kamu alacaklarının tahsil zamanını etkileyen tecil
düzenlemesinin vergi hukukuna egemen olan kanunilik ilkesine uygun inşa
edilmesi gerektiği aşikârdır. Bunun yanında, 6183 sayılı Kanuna egemen olan
ilkeler tecil müessesesi açısından da geçerlidir. 6183 sayılı Kanuna hâkim olan
ilkeler; tahsilatın devamlılığı, vergi alacağının kesinleşmesi, tahsilatta
iktisadilik, vergi alacağının güvence altına alınması, mükelleflere kolaylık
sağlanması, yazılılık, alacaklının para ile tatmini, hapis cezası uygulamama,
modern tahsil yöntemleri kullanma ilkeleridir. Bu çalışmada tecil müessesesi
bahsi geçen ilkeler bakımından değerlendirilmiş, tecilin özellikle tahsilatın
devamlılığı, tahsilatta iktisadilik ve mükelleflere kolaylık sağlanması
ilkelerinin yansıması olan müesseselerden biri olduğu bilgisi ön plana
çıkmıştır. Oldukça eski bir düzenleme olmasına ve ödeme kolaylığı sağlayan
başka düzenlemelerin varlığına rağmen, ekonomik ve mali sıkıntıların yaşandığı
dönemlerde alacaklı açısından tahsilatının devamlılığının, borçlu açısından ödemede
kolaylık sağlanmasının yanında geciken ödemelerde ortaya çıkan tahsil masraflarını ortadan kaldırması tecil
müessesinin vergi icra hukukundaki yerini koruduğu ve önemini arttırdığı
düşüncesine ulaşmamızı sağlamıştır.
Pembuatan Aplikasi Panggilan Darurat Berbasis Android Menggunakan Location Based Services
Authors: Wijaya Ardi 
Published: October 2019

In everyday life we often encounter emergency situations such as accidents, drowning victims, fires, crimes and so on. Certain community may have had socialization or learned how to handle or first aid the emergencies, but not all societies know how to do first aid for emergencies.This research is aimed at building an Android-based emergency call application system for Bengkulu Region so that people can dial important phone numbers and public services when there is a crime or accident. The benefits of this application is as a medium to facilitate users of mobile devices based on Android in making emergency public service calls. From the problems that occur then, the problem of this research is How to Create Android-Based Emergency Call Applications For Bengkulu Region Using Location Based Services. The purpose of this research is to Design and Build Android-Based Emergency Call Applications for Bengkulu Region Using LBS Technology and create easily and quickly Emergency safe Calling System. The place of research is conducted on public service in Bengkulu city and is independently created. Data collection is done by using interview, observation and literature study method. The results showed that Applications that are created can help people to face emergencies so they do not get constrained when looking for agencies contact information that provide assistance services in times of emergency.Keywords : Applications, Emergency Calls, LBS
Traditional Expressions as a Source of Local Wisdom
Authors: Sarman Sarman 
Published: October 2019

Traditional expressions is one of folklore verbal that need to be preserved. Some expressions of traditional contain many teachings, social values, cultural, economic, religiosity, outlook on life, leadership, and even political values, so that the relationship of folklore Bangka language with expressions of folklore is very relevant because some of the culture of a collective that is inherited and passed down through generations. This study aims to describe the value and function of a traditional expression in Bangka community. This study is conducted by qualitative descriptive method and techniques of literature and interviews. Bangka traditional expression has a function as a medium to deliver advice, criticism, jokes, prohibition and religion.Keywords: traditional expressions, functions, qualitative descriptive
Wikipedia som indikator og motor for språkleg revitalisering
Authors: Trosterud Trond 
Published: October 2019

Presentasjon frå Wikipedia-akademiet 2015
Wikipedia finst for 287 språk, og på same måte som språka sjølv, varierer storleiken på dei ulikeWikipediaversjonane. Storleiken på språksamfunnet er likevel berre ein av fleire faktorar som harinnverknad på kor vellukka Wikipedia kan bli.
Tema her er 6 mellomstore Wikipedia-versjonar (70000-400000 artiklar), alle for uralske språk iRussland, dei for moksja, erzja, vestmarisk, austmarisk, udmurtisk og komi. Vi vil sjå på i kor storgrad dei ulike wp-versjonane kan fungere som indikatorar for språksituasjonen i dei ulikespråksamfunna.
Vi vil også sjå på i kor stor grad wp-versjonane er brukbare som språkteknologisk ressurs.
The Inability of Podocytes to Proliferate: Cause, Consequences, and Origin
Authors: Kriz Wilhelm 
Published: October 2019

ABSTRACTThis study presents a theoretical analysis of the problems related to the inability of podocytes to proliferate. The basis of these problems is the very high rate of glomerular filtration. Podocytes do not in general die by apoptosis or necrosis but are lost by detachment from the glomerular basement membrane (GBM) as viable cells. Podocytes situated on the outside of the filtration barrier and attached to the GBM only by their foot processes are permanently exposed to the flow dynamic forces of the high filtration rate tending to detach them from the GBM. The major challenge seems to consist of the high shear stresses on the foot processes within the filtration slits due to filtrate flow. Healthy podocytes are able to resist this challenge, injured podocytes are not, and may undergo foot process detachment, leading to a gap in the podocyte cover of the GBM. This represents a mortal event. Like a dam break, such a leak cannot be repaired. The ongoing exposure to filtrate flow prevents any attempt to close the gap, thus preventing any regeneration including cell proliferation. An improvement of this precarious situation consists of healing by scarring that may involve only one lobule of the glomerulus, permitting the remaining lobules to maintain filtration. An answer to the question of which waste product requires such a high filtration rate for its excretion may be in the huge quantity of circulating peptides, a problem that dates far back in evolution.
Remaining useful life prediction for fractional degradation processes under varying modes
Authors: Xi Xiaopeng , Zhou Donghua , Chen Maoyin , Balakrishnan Narayanaswamy 
Published: October 2019

AbstractDegradation processes of practical chemical engineering systems are difficult to model accurately because of complicated nonlinearities, non‐stationarities, and non‐Markovian properties. Traditional prognostics techniques tend to neglect the multi‐mode switching issue, and therefore cannot be used for predicting the remaining useful life (RUL) of a piece of long‐life equipment, especially when it is continuously operated under varying modes. Specifically, the stationarity of differential data also plays an important role in depicting the evolutionary trend, and further affects the extrapolation procedure for RUL prediction. In this paper, we construct a multi‐mode degradation model with regard to fractional diffusion processes by considering both stationary and non‐stationary increments. The drift term is represented as a time‐related nonlinear function, while the diffusion term is driven by fractional Brownian motion (FBM) or sub‐fractional Brownian motion (sub‐FBM), according to the results of the stationary test. Based on the monitored data, the model is identified by combining change‐point detection and parameter estimation. The closed‐form distribution of RUL is then derived through a weak convergence transformation. A numerical example and a case study of a large blast furnace are provided to evaluate the performance of the proposed prognostics framework.
Morphology‐controlled Tantalum Diselenide Structures as Self‐optimizing Hydrogen Evolution Catalysts
Authors: Wang Min , Zhang Li , Huang Meirong , Liu Yuan , Zhong Yujia , Pan Jialiang , Wang Yiran , Zhu Hongwei 
Published: October 2019

Metallic layered transition metal dichalcogenides (TMDs) nanomaterials based on Group 5 transition metals are attracting substantial interests as alternative catalysts for hydrogen evolution reaction (HER). However, controllable preparation of tantalum diselenide (TaSe2) remains challenging, which has hindered the exploration on its application in HER. Herein, we develop a facile method named surface‐assisted chemical vapor transport (SACVT) for controllable synthesis of TaSe2 plates and nanobelts, by regulating the molar ratio of selenium to tantalum and reaction temperature. Unique quasi‐arrays and self‐supported structure help TaSe2 nanobelt own more active sites and higher ability of charge transfer, so it is superior to TaSe2 plate in electrocatalytic HER. Interestingly, they both exhibit the ability to optimize their morphologies upon cycling for dramatically improved and robust electrocatalytic performance. The self‐optimized structures can increase the effective active surface by exposing more active sites on the basal‐planes and edges, shorten the interlayer electron‐transfer pathways at a thinned domain, and accelerate the charge transfer, which mainly derive from high basal‐plane activity and weak interaction between layers of metallic TaSe2. This work provides a reliable way for controllable synthesis of different TaSe2 structures, motivating further efforts to explore new high‐efficiency catalysts in the large family of metallic TMDs for electrochemical energy conversion.
Highly sensitive detection of GATA1 mutations in patients with myeloid leukemia associated with Down syndrome by combining Sanger and targeted next generation sequencing
Authors: Terui Kiminori , Toki Tsutomu , Taga Takashi , Iwamoto Shotaro , Miyamura Takako , Hasegawa Daisuke , Moritake Hiroshi , Hama Asahito , Nakashima Kentaro , Kanezaki Rika , Kudo Ko , Saito Akiko M. , Horibe Keizo , Adachi Souichi , Tomizawa Daisuke , Ito Etsuro 
Published: October 2019

AbstractMyeloid leukemia associated with Down syndrome (ML‐DS) is characterized by a predominance of acute megakaryoblastic leukemia, the presence of GATA1 mutations and a favorable outcome. Because DS children can also develop conventional acute myeloid leukemia with unfavorable outcome, detection of GATA1 mutations is important for diagnosis of ML‐DS. However, myelofibrosis and the significant frequency of dry taps have hampered practical screening of GATA1 mutations using bone marrow (BM) samples. In response to those problems, 82 patients were enrolled in the Japanese Pediatric Leukemia/Lymphoma Study Group AML‐D11 study. GATA1 mutations were analyzed by Sanger sequencing (SS) using genomic DNA (gDNA) from BM and cDNA from peripheral blood (PB) followed by targeted next‐generation sequencing (NGS) using pooled diagnostic samples. BM and PB samples were obtained from 71 (87%) and 82 (100%) patients, respectively. GATA1 mutations were detected in 46 (56%) and 58 (71%) patients by SS using BM gDNA and PB cDNA, respectively. Collectively, GATA1 mutations were identified in 73/82 (89%) patients by SS. Targeted NGS detected GATA1 mutations in 74/82 (90%) patients. Finally, combining the results of SS with those of targeted NGS, GATA1 mutations were identified in 80/82 (98%) patients. These results indicate that SS using BM gDNA and PB cDNA is a rapid and useful method for screening for GATA1 mutations in ML‐DS patients. Thus, a combination of SS and targeted NGS is a sensitive and useful method to evaluate the actual incidence and clinical significance of GATA1 mutations in ML‐DS patients.
DALI and the persistence of protein shape
Authors: Holm Liisa 
Published: October 2019

AbstractDALI is a popular resource for comparing protein structures. The software is based on distance‐matrix alignment. The associated web server provides tools to navigate, integrate and organize some data pushed out by genomics and structural genomics. The server has been running continuously for the past 25 years. Structural biologists routinely use DALI to compare a new structure against previously known protein structures. If significant similarities are discovered, it may indicate a distant homology, that is, that the structures are of shared origin. This may be significant in determining the molecular mechanisms, as these may remain very similar from a distant predecessor to the present day, for example, from the last common ancestor of humans and bacteria. Meta‐analysis of independent reference‐based evaluations of alignment accuracy and fold discrimination shows DALI at top rank in six out of 12 studies. The web server and standalone software are available from http://ekhidna2.biocenter.helsinki.fi/dali.
Introduction: Storied Spaces of Contemporary Nordic Literature
Authors: Malmio Kristina , Kurikka Kaisa 
Published: October 2019

AbstractThe introduction presents the aims, objectives, and contents of Contemporary Nordic Literature and Spatiality. It offers an overview of the theoretical notions of spatiality used in the chapters and explores some of the key words of the volume (such as spatiality, Nordic literature, and the spatial turn). The chapter introduces the main notions of spatiality in use in the volume, such as the interconnectedness of spatiality to include both humans and non-humans. It also discusses the four sections and the principles of organization of the volume. The introduction problematizes our focus on a special geographical area, namely the continental North, and discusses recent trends in Nordic literature.
On the Commons: A Geocritical Reading of Amager Fælled
Authors: Friis Elisabeth 
Published: October 2019

AbstractThis chapter proposes a geocritical reading of a rather inconspicuous place in Denmark which nonetheless stands out by virtue of its strikingly insistent appearance in Danish literature during the past three years. To read geocritically means, in Bertrand Westphal’s phrasing, to examine “the multifocalization of viewpoints on a given reference space,” and this is precisely what the place that will be examined here makes possible, since quite a lot has actually been written about it recently.Following Westphal, I shall regard the specific place that is of interest here, Amager Fælled (or in English, Amager Common) as a place whose specificity engenders specific movements within the literature that interacts with it.
Mapping a Postmodern Dystopia: Hassan Loo Sattarvandi’s Construction of a Swedish Suburb
Authors: Sarrimo Cristine 
Published: October 2019

AbstractIn his novel Still (2008), the author Sattarvandi maps a postmodern dystopia by locating a few male protagonists in the suburb of Hagalund, which is located outside the capital Stockholm. The place depicted is a space of exile and confinement that is socially deprived and culturally appropriated. The inhabitants are disconnected from the city and the nation, and are instead positioned according to a local-global scale creating a space of interstitiality. When acknowledged as a historical site, Sattarvandi’s dystopian version of this particular suburb emerges as a complex urban space in transformation informed by its early modern, modern as well as postmodern cultural, historical and political contexts.
Living Side by Side in an Individualized Society: Home, Place, and Social Relations in Late Modern Swedish-Language Picturebooks
Authors: Hermansson Kristina 
Published: October 2019

AbstractThis chapter examines the interplay between place and social relations in three Swedish-language picturebooks published in Sweden and Finland between 2006 and 2014. They all deal with issues of neighborhood in late modern society. The stories are primarily situated at a camping site, in a row of terraced houses, and in different flats in a block of apartments and its environment. These works all address questions that are often dealt with by late modern cultural theory, such as individualism, social isolation, and security. The picturebooks also present the most common narrative patterns in children’s literature, namely home-away-home, by somewhat shifting the traditional concept of home as a private, safe place to return to. By primarily utilizing Doreen Massey’s theories, this study explores how the presentations of place interplay with the presentations of social relations.
Love, Longing, and the Smartphone: Lena Andersson, Vigdis Hjorth, and Hanne Ørstavik
Authors: Refsum Christian 
Published: October 2019

AbstractI discuss three novels by three contemporary Nordic writers: Lena Andersson, Vigdis Hjorth, and Hanne Ørstavik. All the novels describe experiences of love, waiting, and longing. In all of them mobile phones serve as apparatuses for availability and for capturing and holding attention. I first present the smartphone as an apparatus in a critical theoretical context, stressing how mobile technology restructures the experience of time and space in late modernity. I then discuss how this challenges the literary discourse on love and longing, which to a large extent has been developed in epistolary genres. Finally, I discuss how Andersson, Hjorth, and Ørstavik describe cell phones and smartphones as apparatuses for desubjectivation and subjectivation in a new critical literary situation.
Stavanger, Pre- and Postmodern: Øyvind Rimbereid’s Poetry and the Tradition of Topographic Verse
Authors: Andersen Hadle Oftedal 
Published: October 2019

AbstractIn this chapter, I aim to give a presentation of the pre-Romantic tradition of topographic verse and show how a dialogue with this tradition is used in the depictions of the Stavanger region in postmodern times in Norwegian writer Øyvind Rimbereid’s poetry, focusing on the dystopian long poem “Solaris Corrected” (2004). As the topographic verse predates the understanding of landscape, it follows that the depiction of the Stavanger region follows other paths. The main point in the poem is that work is what defines man, and region. The presence of an offshore oil industry is the all-encompassing feature, to an extent where the local language changes dramatically, to a mix of all languages surrounding the North Sea basin.