bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Glass Photoresists with High Resolution, Low LER, and High Sensitivity for EUV Lithography
Authors: Peng Xiaoman , Wang Yafei , Xu Jian , Yuan Hua , Wang Liangqian , Zhang Tao , Guo Xudong , Wang Shuangqing , Li Yi , Yang Guoqiang 
Published: May 2018

AbstractNovel molecular glasses (MGs) containing bisphenol A backbone (BPA‐6 and BPA‐10) are synthesized and characterized. BPA‐6 and BAP‐10 are excellent amorphous materials for extreme ultraviolet (EUV) patterning applications with good thermal stability (Td more than 160 °C). The MGs can be used as positive‐tone photoresists combined with triphenylsulfonium perfluoro‐1‐butanesulfonate and trioctylamine dissolved in propylene glycol monomethyl ether acetate. High‐resolution feature sizes as small as 23.1 nm with extremely low line edge roughness (less than 2 nm), high sensitivity (less than 20 mJ cm−2), and good high aspect ratio patterns are obtained by using EUV lithography.
Synthesis of Sub‐100 nm Glycosylated Nanoparticles via a One Step, Free Radical, and Surfactant Free Emulsion Polymerization
Authors: Lunn Andrew M. , Perrier Sébastien 
Published: May 2018

AbstractThe facile synthesis of sub‐100 nm glyco nanoparticles is presented via a one‐step, free radical, and surfactant free emulsion polymerization. It is shown that by using sterically large, hydrophilic glycomonomers such as a lactose acrylamide with the charged azo initiator 4,4′‐azobis(4‐cyanovaleric acid), growing particles are stabilized enough to reproducibly produce well defined (PDi ≤ 0.1) glycoparticles with diameters below 100 nm.
3,3′‐Diindolylmethane Enhances Glucose Uptake Through Activation of Insulin Signaling in 3T3‐L1 Adipocytes
Authors: Choi Kyeong‐Mi , Yoo Hwan‐Soo 
Published: May 2018

ObjectiveIndole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved.Methods3T3‐L1 preadipocytes were differentiated by using a mixture of adipogenic inducers, including a suboptimal concentration of insulin.ResultsDIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. This was associated with DIM‐enhanced phosphorylation of the signaling intermediates Akt, insulin receptor substrate‐1, and insulin receptor early in differentiation.ConclusionsOur findings suggest that DIM may improve insulin sensitivity through the activation of the insulin signaling pathway, leading to enhanced glucose uptake.
Barriers to implementing classroom management and behavior support plans: An exploratory investigation
Authors: Collier‐Meek Melissa A. , Sanetti Lisa M. H. , Boyle Ashley M. 
Published: May 2018

AbstractTeachers are responsible for delivering classroom‐management plans and behavior support plans; however, many struggle to implement them consistently. Low levels of treatment integrity may be the result of various implementation barriers. No study has been conducted to examine teachers’ experience of these barriers within the context of specific interventions. This exploratory study involves the analysis of barriers reported during implementation planning by 33 teachers responsible for delivering classroom‐management plans or behavior support plans. Teachers most frequently indicate struggling to respond to problem behaviors and manage competing responsibilities. Strategies suggested to ameliorate barriers most frequently include re‐teaching the intervention and scheduling implementation.
Theoretical investigation on the excited state intramolecular proton coupled charge transfer phenomenon for a novel fluorophore
Authors: Yin Hang , Shi Ying 
Published: May 2018

AbstractWe theoretically investigate the excited state behaviors of the novel fluorophore tetraphenylethene‐2‐(2′‐hydroxyphenyl)benzothiazole (TPE‐HBT), which was designed based on the intersection of TPE and HBT, using density functional theory and time‐dependent density functional theory methods. Compared with previous experimental results about fluorescence peaks, our calculated results are in good agreement with experimental data, which further confirms that the theoretical level we used is reasonable. Furthermore, our results confirm that the excited state intramolecular proton transfer (ESIPT) process happens upon photoexcitation, which is distinctly monitored by the infrared spectra and the potential energy curves. In addition, the calculation of highest occupied molecular orbital and lowest unoccupied molecular orbital reveals that the electron density change of proton acceptor because of the intramolecular charge transfer (ICT) process in the S1 state induces the ESIPT. Moreover, the transition density matrix is worked out to facilitate deeper insight into the ESIPT coupled ICT process. It is hoped that the present work not only elaborates the ESIPT coupled ICT phenomenon and corresponding mechanisms for the TPE‐HBT but also may be helpful to design and develop new materials and applications involved in TPE‐HBT systems in future.
Permeability and thermal properties of PDMS/LDPE multilayer composite membranes
Authors: Shahidi Kazem , Rodrigue Denis 
Published: May 2018

ABSTRACTThis work reports on the preparation and properties of polydimethylsiloxane (PDMS)/low‐density polyethylene (LDPE) multilayer composite polymer membranes (MCPM) for gas separation applications. The membranes were produced by combining sequential coating with melt‐extrusion/salt leaching techniques. In particular, the gas sorption and permeation properties at different pressure (40–90 psig) and temperature (27–55 °C) are reported with morphology and thermogravimetric properties. The results show that a 20 μm PDMS layer was able to penetrate the microporous LDPE surface layer substrate leading to improved interfacial adhesion. Based on the different gases (CO2, CH4, and C3H8) solubility, permeability, and diffusivity obtained, these membranes are seen as good candidates for industrial gas separations. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018, 56, 1045–1052
Crius: A novel fragment‐based algorithm of de novo substrate prediction for enzymes
Authors: Yao Zhiqiang , Jiang Shuiqin , Zhang Lujia , Gao Bei , He Xiao , Zhang John Z. H. , Wei Dongzhi 
Published: May 2018

AbstractThe study of enzyme substrate specificity is vital for developing potential applications of enzymes. However, the routine experimental procedures require lot of resources in the discovery of novel substrates. This article reports an in silico structure‐based algorithm called Crius, which predicts substrates for enzyme. The results of this fragment‐based algorithm show good agreements between the simulated and experimental substrate specificities, using a lipase from Candida antarctica (CALB), a nitrilase from Cyanobacterium syechocystis sp. PCC6803 (Nit6803), and an aldo‐keto reductase from Gluconobacter oxydans (Gox0644). This opens new prospects of developing computer algorithms that can effectively predict substrates for an enzyme.
Ecosystem‐based environmental flow assessment in a Greek regulated river with the use of 2D hydrodynamic habitat modelling
Authors: Theodoropoulos C. , Skoulikidis N. , Rutschmann P. , Stamou A. 
Published: May 2018

AbstractDespite the long‐term research on the use of hydraulic‐hydrodynamic habitat models (HHMs) for predicting the response of aquatic biota to habitat alteration, their practical application in model‐based environmental flow assessments (EFAs) has been limited due to reasons mainly associated with cost‐effectiveness, time‐efficiency, required expertise, and availability of hydroecological information. In this study, we demonstrate a cost‐effective and time‐efficient application of a benthic‐invertebrate, two‐dimensional, fuzzy rule‐based EFA in a 277‐m long reach in the downstream route of a regulated river in western Greece. Apart from developing ecosystem‐based environmental flow (eflow) scenarios, we highlight the valuable features of HHMs, comment on their disadvantages, and propose working solutions to overcome them. The results of the study show that the hydrology‐based eflow of 0.2 m3/s, initially proposed by the managing authorities, is not sufficient to ensure the long‐term functionality of the downstream benthic communities, as the ecosystem‐based eflow ranged between 0.6 and 2 m3/s. As social resilience relies heavily on ecological resilience, ecosystem‐based approaches can ensure the sustainability of aquatic ecosystems. This study demonstrates, inter alia, that HHMs‐based EFAs can be implemented cost‐effectively and time‐efficiently to serve as an accurate scientific basis for water managers and stakeholders, in search of the fine balance between anthropogenic water demand and long‐term ecosystem integrity and functionality.
Aligning South Africa's National Development Plan with the 2030 Agenda's Sustainable Development Goals: Guidelines from the Policy Coherence for Development movement
Authors: Fourie Willem 
Published: May 2018

AbstractSustainable development depends on coherence between the development policies of recipients and the providers of development assistance. Yet achieving coherence is difficult. This paper examines the extent to which the Policy Coherence for Development movement offers guidelines for aligning national development priorities with global development priorities. This qualitative paper focuses on alignment between South Africa's National Development and its Medium‐Term Strategic Frameworks and the 2030 Agenda and its Sustainable Development Goals. Based on an analysis of policy documents and peer‐reviewed research on the Policy Coherence for Development movement, it is argued that five guidelines might be of relevance for South Africa, namely (i) prioritizing political buy‐in, (ii) safeguarding country ownership of development priorities, (iii) using and improving existing institutional structures and processes, (iv) stimulating cooperation across government departments by using an issue‐based approach and (v) including a long‐term and transnational perspective when considering policy impacts.
Independence screening for high dimensional nonlinear additive ODE models with applications to dynamic gene regulatory networks
Authors: Xue Hongqi , Wu Shuang , Wu Yichao , Ramirez Idarraga Juan C. , Wu Hulin 
Published: May 2018

Mechanism‐driven low‐dimensional ordinary differential equation (ODE) models are often used to model viral dynamics at cellular levels and epidemics of infectious diseases. However, low‐dimensional mechanism‐based ODE models are limited for modeling infectious diseases at molecular levels such as transcriptomic or proteomic levels, which is critical to understand pathogenesis of diseases. Although linear ODE models have been proposed for gene regulatory networks (GRNs), nonlinear regulations are common in GRNs. The reconstruction of large‐scale nonlinear networks from time‐course gene expression data remains an unresolved issue. Here, we use high‐dimensional nonlinear additive ODEs to model GRNs and propose a 4‐step procedure to efficiently perform variable selection for nonlinear ODEs. To tackle the challenge of high dimensionality, we couple the 2‐stage smoothing‐based estimation method for ODEs and a nonlinear independence screening method to perform variable selection for the nonlinear ODE models. We have shown that our method possesses the sure screening property and it can handle problems with non‐polynomial dimensionality. Numerical performance of the proposed method is illustrated with simulated data and a real data example for identifying the dynamic GRN of Saccharomyces cerevisiae.
Writing about Workers, Reflecting on Dictatorship and Neoliberalism: Chilean Labor History and the Pinochet Dictatorship
Authors: Vergara Ángela 
Published: May 2018

AbstractThis article explores the trajectory of Chilean labor history and its recent efforts to study workers’ experiences under the Augusto Pinochet dictatorship (1973–1990). Influenced by the impact of dictatorship on Chilean society as well as global historiographical debates, Labor Studies became an interdisciplinary and transnational field in Chile. This article focuses on the different academic traditions that have intersected with and contributed to the study of workers’ experiences under the dictatorship. It considers the multiple origins of New Labor Studies and includes the social history of both rural and urban movements, labor sociology, feminist historiography, and transnational history. It also looks at the multiple debates taking place in Chile and in other parts of the world. Bringing them together offers the opportunity to see the intersections, collaborations, and influences that have made the study of Chilean workers a dynamic field.
Ionospheric Response to the Solar Eclipse of 21 August 2017 in Millstone Hill (42N) Observations
Authors: Goncharenko Larisa P. , Erickson Philip J. , Zhang Shun‐Rong , Galkin Ivan , Coster Anthea J. , Jonah Olusegun F. 
Published: May 2018

AbstractThis study examines the ionospheric changes associated with the solar eclipse of 21 August 2017. The effects associated with the passage of the eclipse shadow were observed more than 1,000 km away from the totality at midlatitudes using the Millstone Hill incoherent scatter radar and digisonde. There was a 30–40% decrease in electron density, a 100‐ to 220‐K decrease in electron temperature, and a 50‐ to 140‐K decrease in ion temperature. Surprisingly, the greatest decrease in electron density occurred above 200 km. The most unexpected effect was a large 20‐ to 40‐m/s upward vertical drift observed in the topside ionosphere right after the local maximum obscuration. We suggest that this drift led to a posteclipse increase in the topside electron density.
Epithelial cell-derived cytokines CST3 and GDF15 as potential therapeutics for pulmonary fibrosis
Authors: Kim Young-Im , Shin Hyun-Woo , Chun Yang-Sook , Cho Chung-Hyun , Koh Jaemoon , Chung Doo Hyun , Park Jong-Wan 
Published: May 2018

AbstractWhile wound healing is completed, the epithelium functions to normalize the interstitial context by eliminating fibroblasts excited during matrix reconstruction. If not, tissues undergo pathologic fibrosis. Pulmonary fibrosis is a fatal and hardly curable disorder. We here tried to identify epithelium-derived cytokines capable of ameliorating pulmonary fibrosis. Human lung fibroblasts were inactivated in epithelial cell-conditioned media. Cystatin C (CST3) and growth differentiation factor 15 (GDF15) were found to be enriched in the conditioned media and to inhibit the growth and activation of lung fibroblasts by inactivating the TGF–Smad pathway. In mouse and human lungs with interstitial fibrosis, CST3 and GDF15 expressions were markedly reduced, and the restoration of these cytokines alleviated the fibrotic changes in mouse lungs. These results suggest that CST3 and GDF15 are bona fide regulators to prevent excessive proliferation and activation of fibroblasts in injured lungs. These cytokines could be potential therapeutics for ameliorating interstitial lung fibrosis.
SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment
Authors: Stoffel Wilhelm , Jenke Britta , Schmidt-Soltau Inga , Binczek Erika , Brodesser Susanne , Hammels Ina 
Published: May 2018

Abstract
Neutral sphingomyelinase smpd3 is most abundantly expressed in neurons of brain. The function of SMPD3 has remained elusive. Here, we report a pathogenetic nexus between absence of SMPD3 in the Golgi compartment (GC) of neurons of the smpd3-/- mouse brain, inhibition of Golgi vesicular protein transport and progressive cognitive impairment. Absence of SMPD3 activity in the Golgi sphingomyelin cycle impedes remodeling of the lipid bilayer, essential for budding and multivesicular body formation. Importantly, we show that inhibition of the Golgi vesicular protein transport causes accumulation of neurotoxic proteins APP, Aβ and phosphorylated Tau, dysproteostasis, unfolded protein response, and apoptosis, which ultimately manifests in progressive cognitive decline, similar to the pathognomonic signatures of familial and sporadic forms of Alzheimer´s disease. This discovery might contribute to the search for other primary pathogenic mechanisms, which link perturbed lipid bilayer structures and protein processing and transport in the neuronal Golgi compartment and neurodegeneration and cognitive deficits.
Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation
Authors: Inoue Nobuko , Nishizumi Hirofumi , Naritsuka Hiromi , Kiyonari Hiroshi , Sakano Hitoshi 
Published: May 2018

AbstractIn mammals, neural circuits are formed based on a genetic program and further refined by neuronal activity during the neonatal period. We report that in the mouse olfactory system, the glomerular map is not merely refined but newly connected to second-order neurons by odorant-receptor-derived neuronal activity. Here, we analyzed a pair of molecules, Sema7A, expressed in olfactory sensory neurons (OSNs) in an activity-dependent manner, and PlxnC1, localized to dendrites of mitral/tufted (M/T) cells in the first week after birth. In Sema7A or PlxnC1 knockout (KO) mice, initiation of synapse formation and dendrite selection of M/T cells were perturbed. Reconstitution and rescue experiments demonstrated that Sema7A–PlxnC1 interaction is essential to form the post-synaptic assembly. Pharmacological blocking experiments indicated that synaptic transmission triggers primary dendrite selection by synaptic competition. We conclude that Sema7A signaling is key to inducing activity-dependent post-synapse events and dendrite selection in M/T-cells during the neonatal period.
Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling
Authors: Nzou Goodwell , Wicks R. T. , Wicks E. E. , Seale S. A. , Sane C. H. , Chen A. , Murphy S. V. , Jackson J. D. , Atala A. J. 
Published: May 2018

AbstractThe integral selectivity characteristic of the blood brain barrier (BBB) limits therapeutic options for many neurologic diseases and disorders. Currently, very little is known about the mechanisms that govern the dynamic nature of the BBB. Recent reports have focused on the development and application of human brain organoids developed from neuro-progenitor cells. While these models provide an excellent platform to study the effects of disease and genetic aberrances on brain development, they may not model the microvasculature and BBB of the adult human cortex. To date, mostin vitroBBB models utilize endothelial cells, pericytes and astrocytes. We report a 3D spheroid model of the BBB comprising all major cell types, including neurons, microglia and oligodendrocytes, to recapitulate more closely normal human brain tissue. Spheroids show expression of tight junctions, adherens junctions, adherens junction-associated proteins and cell specific markers. Functional assessment using MPTP, MPP+ and mercury chloride indicate charge selectivity through the barrier. Junctional protein distribution was altered under hypoxic conditions. Our spheroid model may have potential applications in drug discovery, disease modeling, neurotoxicity and cytotoxicity testing.
The amino acid selected for generating mutant TbpB antigens defective in binding transferrin can compromise the in vivo protective capacity
Authors: Guizzo João Antônio , Chaudhuri Somshukla , Prigol Simone Ramos , Yu Rong-hua , Dazzi Cláudia Cerutti , Balbinott Natalia , Frandoloso Gabriela Paraboni , Kreutz Luiz Carlos , Frandoloso Rafael , Schryvers Anthony Bernard 
Published: May 2018

AbstractHaemophilus parasuis is the causative agent of the Glässer’s disease (GD), one of the most important bacterial diseases that affect young pigs worldwide. GD prevention based on vaccination is a major concern due to the limited cross-protection conferred by the inactivated whole cell vaccines used currently. In this study, vaccines based on two mutant recombinant proteins derived from transferrin binding protein B of H. parasuis (Y167A-TbpB and W176A-TbpB) were formulated and evaluated in terms of protection against lethal challenge using a serovar 7 (SV7) H. parasuis in a high susceptibility pig model. Our results showed that H. parasuis strain 174 (SV7) is highly virulent in conventional and colostrum-deprived pigs. The Y167A-TbpB and W176A-TbpB antigens were immunogenic in pigs, however, differences in terms of antigenicity and functional immune response were observed. In regard to protection, animals immunized with Y167A-TbpB antigen displayed 80% survival whereas the W176A-TbpB protein was not protective. In conjunction with previous studies, our results demonstrate, (a) the importance of testing engineered antigens in an in vivo pig challenge model, and, (b) that the Y167A-TbpB antigen is a promising antigen for developing a broad-spectrum vaccine against H. parasuis infection.
Identification of a unique Radical SAM methyltransferase required for the sp3-C-methylation of an arginine residue of methyl-coenzyme M reductase
Authors: Deobald Darja , Adrian Lorenz , Schöne Christian , Rother Michael , Layer Gunhild 
Published: May 2018

AbstractThe biological formation of methane (methanogenesis) is a globally important process, which is exploited in biogas technology, but also contributes to global warming through the release of a potent greenhouse gas into the atmosphere. The last and methane-releasing step of methanogenesis is catalysed by the enzyme methyl-coenzyme M reductase (MCR), which carries several exceptional posttranslational amino acid modifications. Among these, a 5-C-(S)-methylarginine is located close to the active site of the enzyme. Here, we show that a unique Radical S-adenosyl-L-methionine (SAM) methyltransferase is required for the methylation of the arginine residue. The gene encoding the methyltransferase is currently annotated as “methanogenesis marker 10” whose function was unknown until now. The deletion of the methyltransferase gene ma4551 in Methanosarcina acetivorans WWM1 leads to the production of an active MCR lacking the C-5-methylation of the respective arginine residue. The growth behaviour of the corresponding M. acetivorans mutant strain and the biophysical characterization of the isolated MCR indicate that the methylated arginine is important for MCR stability under stress conditions.