bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the formation of hörnesite in a Fatimid manuscript folio
Authors: van Dyke Yana , Centeno Silvia A. , Carò Federico , Frantz James H. , Wypyski Mark T. 
Published: September 2018

Abstract
A folio fragment attributed to the Fatimid period in Egypt was found to bear tufts of white crystals associated with the orange-brown and yellow paints. Raman spectroscopy identified a mixture of arsenic sulfide-based pigments in the orange-brown and yellow areas, along with vermilion in the outlines of the figures. X-ray microdiffraction, Raman spectroscopy, and energy-dispersive X-ray spectrometry identified the white crystals as hörnesite [Mg3(AsO4)2·8H2O]. Synthesis of this compound at ambient temperature and elevated relative humidity over a period of 3 years, on paper painted with arsenic sulfide pigments and treated with magnesium carbonate, suggests the possibility that a magnesium-based deacidification treatment may have contributed to the formation of this phase on the folio fragment. This work highlights the potential damage that may be sustained by arsenic sulfide-based media through exposure to deacidifying suspensions such as the ones often used in the past to treat works of art on paper and historic documents.
Phase I Study of the BRAF Inhibitor Vemurafenib in Combination With the Mammalian Target of Rapamycin Inhibitor Everolimus in Patients With BRAF-Mutated Malignancies
Authors: Subbiah Vivek , Sen Shiraj , Hess Kenneth R. , Janku Filip , Hong David S. , Khatua Soumen , Karp Daniel D. , Munoz Javier , Falchook Gerald S. , Groisberg Roman , Tsimberidou Apostolia M. , Sherman Steven I. , Hwu Patrick , Meric-Bernstam Funda 
Published: September 2018

Purpose Parallel activation of the phosphatidylinositol 3-kinase–mammalian target of rapamycin pathway represents a mechanism of primary and acquired resistance to BRAF-targeted therapy, but the two pathways have yet to be cotargeted in humans. We performed a phase I study to evaluate the safety and activity of the BRAF inhibitor vemurafenib in combination with the mammalian target of rapamycin inhibitor everolimus in BRAF-mutated advanced solid tumors. Patients and Methods We performed a 3+3 dose-escalation study with escalating doses of both oral (PO) vemurafenib administered twice a day and PO everolimus administered daily. Results Twenty patients with advanced cancers were enrolled. The median adult age was 64 years (range, 17 to 85 years); two pediatric patients were 10 and 13 years old. Patients were heavily pretreated with prior BRAF or MEK inhibitors (n = 11), phase I clinical trial therapy (n = 10), surgery (n = 18), radiation therapy (n = 11), and chemotherapy (n=13). One of the two pediatric patients initially experienced grade 3 rash, but after dermatologic intervention, the patient remains on trial with partial response and no dose reduction at time of analysis. Four dose-limiting toxicities (rash, n = 1; fatigue, n = 3) were observed at dose level 2. Therefore, dose level 1 (vemurafenib 720 mg PO twice a day and everolimus 5 mg PO daily) was the maximum-tolerated dose. Overall, four patients (22%) had a partial response and nine patients (50%) had stable disease as best response. One pediatric patient with pleomorphic xanthroastrocytoma remains on protocol with continued clinical response after 38 cycles. Conclusion The combination of vemurafenib 720 mg PO twice a day and everolimus 5 mg PO daily is safe and well tolerated and has activity across histologies, with partial responses noted in advanced non–small-cell lung cancer, melanoma, optic nerve glioma, and xanthroastrocytoma, including patients who previously experienced progression on BRAF and/or MEK inhibitor therapy. Further investigation in a larger cohort of molecularly matched patients is warranted.
The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons
Authors: Kurabayashi Nobuhiro , Tanaka Aiki , Nguyen Minh Dang , Sanada Kamon 
Published: September 2018

ABSTRACT
Newborn neurons in the developing neocortex undergo radial migration, a process that is coupled with their precise passage from multipolar to bipolar shape. The cell-extrinsic signals that govern this transition are, however, poorly understood. Here, we find that lysophosphatidic acid (LPA) signaling contributes to the establishment of a bipolar shape in mouse migratory neurons through LPA receptor 4 (LPA4). LPA4 is robustly expressed in migratory neurons. LPA4-depleted neurons show impaired multipolar-to-bipolar transition and become arrested in their migration. Further, LPA4-mediated LPA signaling promotes formation of the pia-directed process in primary neurons overlaid on neocortical slices. In addition, LPA4 depletion is coupled with altered actin organization as well as with destabilization of the F-actin-binding protein filamin A (FlnA). Finally, overexpression of FlnA rescues the morphology and migration defects of LPA4-depleted neurons. Thus, the LPA-LPA4 axis regulates bipolar morphogenesis and radial migration of newborn cortical neurons via remodeling of the actin cytoskeleton.
Value of PET/MRI for assessing tumor resectability in NSCLC—intra-individual comparison with PET/CT
Authors: Messerli Michael , de Galiza Barbosa Felipe , Marcon Magda , Muehlematter Urs J , Stolzmann Paul , Warschkow René , Delso Gaspar , ter Voert Edwin EGW , Huellner Martin W , Frauenfelder Thomas , Veit-Haibach Patrick 
Published: September 2018

Objective:
The purpose of this study was to compare the diagnostic accuracy of positron emission tomography (PET)/MRI with PET/CT for determining tumor resectability of non-small cell lung cancer (NSCLC).

Methods:
Sequential trimodality PET/CT/MRI was performed in 36 patients referred with the clinical question of resectability assessment in NSCLC. PET/CT and PET/MR images including T 1 weighted sequence (T 1-Dixon) and respiration gated T 2 weighted sequence (T 2-Propeller) were evaluated for resectability-defining factors; i.e. longest diameter of the tumor, minimal tumor distance to the carina, mediastinal invasion, invasion of the carina, pleural infiltration, pericardial infiltration, diaphragm infiltration, presence of additional nodules.

Results:
There was no significant difference of maximal axial diameter measurements of the primary lung tumors and narrow limits of agreement in Bland–Altman analysis ranging from −11.1  mm to + 11.8  mm for T 2-Propeller and from −14.3  mm to + 13.8  mm for T 1-Dixon sequence. A high agreement of PET/MR with PET/CT for the different resectability-defining factors was observed (k from 0.769 to 1.000). There was an excellent agreement of T 2-Propeller sequence and CT for additional pulmonary nodule detection (k of 0.829 and 0.833), but only a moderate and good agreement using T 1-Dixon sequence (k of 0.484 and 0.722).

Conclusion:
In NSCLC the use of PET/MRI, including a dedicated pulmonary MR imaging protocol, provides a comparable diagnostic value for determination of tumor resectability compared to PET/CT.

Advances in knowledge:
Our findings suggest that whole body PET/MRI can safely be used for the local staging of NSCLC patients. Further studies are warranted to determine whether it is feasible to integrate an imaging sequence in a whole body PET/MRI setting with the potential advantage of detection of liver or brain metastases.
Case Report: A nine year follow-up for a pacemaker generator poly-tetra-fluoro-ethylene coating for allergic reactions to pacemaker compounds
Authors: Slim Mehdi , Neffati Elies , Lagren Afef , Kortas Chokri , Tarmiz Amine , Gribba Rym , Boughzela Essia 
Published: September 2018

Background: Allergic reaction to pacemaker compounds is a rare complication of cardiac pacing. Initial management is difficult because accurate diagnosis is often delayed. The tendency is to initially suspect a bacterial infection, rather than to quickly rule out an allergy to the pacemaker components. Management of this condition is difficult and not well established. Case presentation: A 75-year-old man underwent a dual chamber pacemaker implantation. The patient needed two generator re-implantations because of sterile skin necrosis. Pace maker allergic reaction was suspected despite non-conclusive skin patch testing. The patient underwent pacemaker system removal and re-implantation of poly-tetra-fluoro-ethylene sheet coated generator in a retropectoral position. Subsequently, there has been no externalization or recurrence in nine years of follow-up. Take-away lesson: Contact allergy to pacemakers is often unrecognized. Once infection has been excluded, allergy testing must be performed. The only valuable treatment is the removal of all the system components, followed by a replacement with hypoallergenic material. Polytetrafluoroethylene coated materials can be effective to prevent recurrence.
seqCAT: a Bioconductor R-package for variant analysis of high throughput sequencing data
Authors: Fasterius Erik , Al-Khalili Szigyarto Cristina 
Published: September 2018

High throughput sequencing technologies are flourishing in the biological sciences, enabling unprecedented insights into e.g. genetic variation, but require extensive bioinformatic expertise for the analysis. There is thus a need for simple yet effective software that can analyse both existing and novel data, providing interpretable biological results with little bioinformatic prowess. We present seqCAT, a Bioconductor toolkit for analysing genetic variation in high throughput sequencing data. It is a highly accessible, easy-to-use and well-documented R-package that enables a wide range of researchers to analyse their own and publicly available data, providing biologically relevant conclusions and publication-ready figures. SeqCAT can provide information regarding genetic similarities between an arbitrary number of samples, validate specific variants as well as define functionally similar variant groups for further downstream analyses. Its ease of use, installation, complete data-to-conclusions functionality and the inherent flexibility of the R programming language make seqCAT a powerful tool for variant analyses compared to already existing solutions. A publicly available dataset of liver cancer-derived organoids is analysed herein using the seqCAT package, demonstrating that the organoids are genetically stable. A previously known liver cancer-related mutation is additionally shown to be present in a sample though it was not listed in the original publication. Differences between DNA- and RNA-based variant calls in this dataset are also analysed revealing a high median concordance of 97.5%.
Establishing an international laboratory network for neglected tropical diseases: Understanding existing capacity in five WHO regions
Authors: Dean Laura , Njelesani Janet , Mulamba Charles , Dacombe Russell , Mbabazi Pamela S. , Bates Imelda 
Published: September 2018

Background. Limited laboratory capacity is a significant bottleneck in meeting global targets for the control and elimination of neglected tropical diseases (NTD). Laboratories are essential for providing clinical data and monitoring data about the status and changes in NTD prevalence, and for detecting early drug resistance. Currently NTD laboratory networks are informal and specialist laboratory expertise is not well publicised, making it difficult to share global expertise and provide training, supervision, and quality assurance for NTD diagnosis and research. This study aimed to identify laboratories within five World Health Organisation regions (South-East Asia, Eastern Mediterranean, Americas, Western Pacific and Europe) that provide NTD services and could be regarded as national or regional reference laboratories, and to conduct a survey to document their networks and capacity to support NTD programmes. Methods. Potential NTD reference laboratories were identified through systematic searches, snowball sampling and key informants. Results. Thirty-two laboratories responded to the survey. The laboratories covered 25 different NTDs and their main regional and national roles were to provide technical support and training, research, test validation and standard setting. Two thirds of the laboratories were based in academic institutions and almost half had less than 11 staff. Although greater than 90 per cent of the laboratories had adequate technical skills to function as an NTD reference laboratory, almost all laboratories lacked systems for external verification that their results met international standards. Conclusions. This study highlights that although many laboratories believed they could act as a reference laboratory, only a few had all the characteristics required to fulfil this role as they fell short in the standard and quality assurance of laboratory processes. Networks of high quality laboratories are essential for the control and elimination of disease and this study presents a critical first step in the development of such networks for NTDs.
Cash Hedging in a Supply Chain
Authors: Kouvelis Panos , Wu Xiaole , Xiao Yixuan 
Published: September 2018

We study hedging cash-flow risks in a supply chain where firms invest internal funds to improve production efficiencies. We offer a decomposition framework to capture the cost-reduction and flexibility effect of hedging. It allows us to understand how a firm’s hedging choice depends on its supply chain partner’s decision, and how such interaction is affected by supply chain characteristics such as market size, cash-flow volatility, and correlation. When firms’ cash flows are independent of each other, they are more likely to hedge with a larger market size. When cash flows are correlated, the impact of market size and volatility on firms’ hedging decisions presents multiple patterns, contingent on whether their risks amplify or offset each other. This paper was accepted by Gustavo Manso, finance.
SCC-S2 Facilitates Tumor Proliferation and Invasion via Activating Wnt Signaling and Depressing Hippo Signaling in Colorectal Cancer Cells and Predicts Poor Prognosis of Patients
Authors: Yang Chuanjia , Xu Weixue , Meng Xiangzhen , Zhou Siqi , Zhang Minglu , Cui Dongxu 
Published: September 2018

Summary SCC-S2 overexpression has been implicated in several human cancers, its correlation with prognosis and the mechanism how it reserved biological roles are still uncertain. The current study demonstrated that, in 142 archived colorectal carcinoma (CRC) tissue samples, SCC-S2 expression was significantly correlated with higher histological grade ( p=0.001), tumor invasion ( p=0.001), advanced Dukes staging ( p=0.002), positive regional lymph node metastasis ( p=0.024), and poor overall survival ( p<0.001). MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and Transwell assays showed that SCC-S2 significantly promoted the proliferation and invasion. SCC-S2 expression was also accompanied by the overexpression CyclinD1, matrix metalloproteinase-7 (MMP-7), active-β-catenin, yes-associated protein (YAP), and connective tissue growth factor (CTGF), as well as the depression of p-large tumor suppressor kinase 1 (p-LATS1) and p-YAP. Moreover, SCC-S2 interacted and colocalized with LATS1, the interaction may interrupt Hippo signaling and thereafter activate canonical Wnt signaling. In conclusion, our data suggested that SCC-S2 was associated with the progression and unfavorable prognosis of CRCs. Meanwhile, SCC-S2 facilitated canonical Wnt signaling and its downstream effectors (CyclinD1, MMP-7) and promoted tumor proliferation and invasion, which depended on the inhibition of Hippo signaling induced by SCC-S2-LATS1 interaction. These results indicated that SCC-S2 might be used as a novel target for the prevention and treatment of colorectal cancer.
Queer Border Objects and the Sucio Material Politics of Migration in the U.S.–Mexico Borderlands
Authors: Masri Hana 
Published: September 2018

Abstract
Although the dynamic role of the material in migration captivates scholarly imagination, little attention has been given to the ways that objects left behind in the U.S.–Mexico borderlands indicate sexuality and gender. This article brings together queer migration scholarship and new materialist perspectives to examine the rhetoric of images from the photo series “El Sueño Americano,” which depicts things confiscated from migrants by U.S. Customs and Border Protection. What I call the queer border objects of the series offer up fruitful ground for moving toward a politics that disentangles itself from fixed identities in order to move toward coalitional queerness, the likes of which, as Cathy J. Cohen describes, is built from a shared marginality to power. Whether or not the people who discarded them identify as queer, border objects can be read queerly because they communicate how sexuality and gender, as regimes, shape migration and designate whole groups of people as surplus to the nation.
Neruda
Authors: Machuca Ahumada Antonio , Pereira Domínguez Carmen 
Published: September 2018

En 1948, el poeta y senador comunista Pablo Neruda, como algunos de sus compañeros, es perseguido una vez que el partido comunista es declarado ilegal en Chile. Neruda es una gran referencia para la gente sencilla chilena. Por petición del presidente Gabriel González Videla, el policía Óscar Peluchonneau se encarga de su persecución y se obceca con su captura. Neruda es ahora un poeta convertido en arma, en el punto de mira. Vive en la clandestinidad, en casas de conocidos, junto a su mujer, la pintora Delia del Carril. Escribe su épico Canto General en 1950, e intenta huir del país. Mientras tanto, en Europa, ante la búsqueda obsesiva del policía, aumenta la leyenda del poeta apoyado por artistas, especialmente por su amigo Picasso. Pero Neruda utiliza este seguimiento para recrearse transformándose en un símbolo universal de libertad y en un mito literario.
âˆ’174 G/C polymorphism of interleukin 6 gene is not significantly different in Turkish professional short and long distance runners
Authors: Arica Secil , Solgun Huseyin Avni , Demirel Dengi Ayse Seda , Bakmaz Enver , Akçay Teoman , Kapici Sezgin , Sercan Canan , Ulucan Korkut 
Published: September 2018

Interleukin-6 (IL-6) is a kind of multifunctional cytokine and involved in mediating muscle repair metabolism, and therefore athletic capacity. Muscular and circulating IL-6 levels increase in response to physical exercise. Responsible gene coding for IL-6 has a functional polymorphism in its promoter region, -174 G/C (rs1800795). We aimed to analyze the association of G allele and GG genotype in Turkish professional athletes and compare the allelic and genotypic difference between short distance and long distance runners. For this purpose, we enrolled 40 (24 short distance runners and 16 long distance runners) Turkish professional athletes to the study. Real time genotyping procedure was carried out to determine the -174 G/C polymorphism. G allele and GG genotype was more prevalent than the others in our cohort. We found no statistically significant difference between short and long distance runners in the terms of genotype (p=0.07). Our study suggests that-174 G/C polymorphism of IL-6 gene differs in athletes, G allele and GG genotype is higher than the other ones, at least in Turkish athletes, and therefore should be taken into consideration when determining genetic aspects of athletes. Further studies are necessary to confirm our results and show the effect of the given polymorphism in sports science.
FID-Lizenzen sichtbar und suchbar machen: Der Zentrale Nachweis für FID-Lizenzen – Konzept, Umsetzung und Datenmanagement
Authors: Glaab-Kühn Friederike , Kittelmann Maike 
Published: September 2018

Zusammenfassung
Mit der wachsenden Zahl an zugänglichen FID-Lizenzen wurde es immer wichtiger, die FID-Lizenzen zentral nachzuweisen. Zu diesem Zweck hat das Kompetenzzentrum für Lizenzierung elektronischer Ressourcen im DFG-geförderten System der „Fachinformationsdienste für die Wissenschaft“ einen Zentralen Nachweis mit Informationen zu allen verfügbaren FID-Lizenzen aufgebaut. Der Artikel präsentiert die damit verbundenen konzeptionellen Überlegungen sowie die Festlegungen zur Umsetzung. Anhand von Workflows, Dokumentation und Qualitätsmanagement wird veranschaulicht, wie das Datenmanagement für den Zentralen Nachweis umgesetzt wurde.
Robust physiological control of rotary blood pumps for heart failure therapy
Authors: Rüschen Daniel , Opitz Sebastian , von Platen Philip , Korn Leonie , Leonhardt Steffen , Walter Marian 
Published: September 2018

Abstract
Left ventricular assist devices (LVADs) have become a viable alternative to heart transplantation in heart failure therapy. In clinical practice, rotary blood pumps used as LVADs are operated at a constant rotational speed and thus do not adapt to the varying demand of the patient. This paper presents a robust control approach for automatic adaptation of the blood pump speed to the blood flow demand of the patient’s body, which enables a defined load sharing between an LVAD and the native ventricle. Robust stability was checked using a detailed model of the human cardiovascular system with uncertainties that describe the most important native physiological control loops as well as a range of pathologies. The robust assistance controller was tested in an in vivo setup and was able to stabilize the cardiovascular system after myocardial infarction.
Free Vibration Analysis of Single Walled Carbon Nanotube with Exponentially Varying Stiffness
Authors: Jena Subrat Kumar , Chakraverty S. 
Published: September 2018

Abstract
In this paper, Differential Quadrature Method (DQM) is applied to investigate free vibration of Single Walled Carbon Nanotubes (SWCNTs) with exponentially varying stiffness based on non-local Euler-Bernoulli beam theory. Application of DQ method in the governing differential equation converts the problem to a generalized eigenvalue problem and its solution gives frequency parameters. Convergence of the results show that DQM solutions converge fast. In this article, a detailed investigation has been reported and MATLAB code has been developed to analyze the numerical results for different scaling parameters as well as for four types of boundary conditions. Present results are compared with other available results and are found to be in good agreement.
Archaeological Knowledge Production and Global Communities: Boundaries and Structure of the Field
Authors: Laužikas Rimvydas , Dallas Costis , Thomas Suzie , Kelpšienė Ingrida , Huvila Isto , Luengo Pedro , Nobre Helena , Toumpouri Marina , Vaitkevičius Vykintas 
Published: September 2018

Abstract
Archaeology and material cultural heritage enjoys a particular status as a form of heritage that, capturing the public imagination, has become the locus for the expression and negotiation of regional, national, and intra-national cultural identities. One important question is: why and how do contemporary people engage with archaeological heritage objects, artefacts, information or knowledge outside the realm of an professional, academically-based archaeology? This question is investigated here from the perspective of theoretical considerations based on Yuri Lotman’s semiosphere theory, which helps to describe the connections between the centre and peripheries of professional archaeology as sign structures. The centre may be defined according to prevalent scientific paradigms, while periphery in the space of creolisation in which, through interactions with other culturally more distant sign structures, archaeology-related nonprofessional communities emerge. On the basis of these considerations, we use collocation analysis on representative English language corpora to outline the structure of the field of archaeology-related nonprofessional communities, identify salient creolised peripheral spaces and archaeology-related practices, and develop a framework for further investigation of archaeological knowledge production and reuse in the context of global archaeology.