bluuebunny/crossref_metadata_2025_split huggingface dataset:
Information systems project teams: factors for high performance
Authors: Moura Isabel , Dominguez Caroline , Varajão João 
Published: October 2018

Purpose
The purpose of this research is twofold: identify and gain a better insight on factors that can influence high performance of Information Systems (IS) project teams from the perspective of IS professionals (i.e. team members and leaders), and thus contribute to the general discussion on high-performance project teams; and offer both IS project team members and their project managers some feedback on how to build and manage teams more constructively and to enhance team performance in today’s demanding business environment.

Design/methodology/approach
The authors used an exploratory case study of a small-size holding company and a qualitative analysis of the data to address the research questions.

Findings
Results show a set of perceived factors that can influence high team performance in IS projects. Participants’ perceptions barely coincide. For instance, mutual trust was the only factor suggested as facilitating high team performance by 5 participants (out of 13). Differences may be because of participants’ characteristics (e.g. time on the job). All perceived factors are classified in the literature as nontechnical (i.e. having to do with behavioral and/or socio-organizational matters of project management).

Originality/value
This paper is among the very few empirical studies consolidating knowledge on high-performance IS project teams (e.g. it is still unclear if there are IS project team-specific factors that influence high performance). For the highly technical IS industry, this study came across human-centric factors transversal to different project teams.
Preference for realistic art predicts support for Brexit
Authors: Carl Noah , Richards Lindsay , Heath Anthony 
Published: October 2018

AbstractFollowing the UK’s EU referendum in June 2016, there has been considerable interest from scholars in understanding the characteristics that differentiate Leave supporters from Remain supporters. Since Leave supporters score higher on conscientiousness but lower on neuroticism and openness, and given their general proclivity toward conservatism, we hypothesized that preference for realistic art would predict support for Brexit. Data on a large nationally representative sample of the British population were obtained, and preference for realistic art was measured using a four‐item binary choice test. Controlling for a range of personal characteristics, we found that respondents who preferred all four realistic paintings were 15–20 percentage points more likely to support Leave than those who preferred zero or one realistic paintings. This effect was comparable to the difference in support between those with a degree and those with no education, and was robust to controlling for the respondent’s party identity.
Effect of high‐fat, standard, and functional food meals on esophageal and gastric pH in patients with gastroesophageal reflux disease and healthy subjects
Authors: Fan Wen Juan , Hou Yuan Tao , Sun Xiao Hong , Li Xiao Qing , Wang Zhi Feng , Guo Meng , Zhu Li Ming , Wang Ning , Yu Kang , Li Jing Nan , Ke Mei Yun , Fang Xiu Cai 
Published: October 2018

ObjectivesTo investigate the effects of different test meals on esophageal and intragastric pH in patients with gastroesophageal reflux disease (GERD) and healthy subjects and to demonstrate the relationship between esophageal acid exposure (EAE) and gastric pH.MethodsWe enrolled patients with reflux esophagitis (RE; n = 15), nonerosive reflux disease (NERD; n = 12) and healthy subjects (n = 10). Four pH electrodes were used to monitor the pH of the distal esophagus, upper border of the lower esophageal sphincter, gastric fundus, and gastric body for 26 hours. Isocaloric and isovolumetric high‐fat, standard, and functional meals were supplied randomly to the participants. The EAE and gastric acidity of each meal in fasting and postprandial states were compared.ResultsHigh‐fat meals significantly increased postprandial EAE in patients with RE and NERD. EAE was higher after a high‐fat meal than after a standard or functional food meals at the fourth hour postprandially in patients with RE (P < 0.05). Patients with NERD reported fewer symptoms after a functional food meal than after high‐fat and standard meals (0 [interquartile range {IQR} 0–1] vs 1 [IQR 0–2] vs 3 [IQR 1–4], P = 0.014). Compared with high‐fat and standard meals, functional food meal significantly decreased gastric acidity in patients with RE. EAE was significantly related to gastric acidity in patients with RE.ConclusionsHigh‐fat meals increased EAE in patients with RE and NERD. Functional food could serve as adjuvant therapy in GERD patients. EAE was related to gastric acidity in RE patients.
Oncogenic HBXIP enhances ZEB1 through Sp1 to accelerate breast cancer growth
Authors: Jiang Yang , Wang Dan , Ren Hui , Shi Ying , Gao Yufei 
Published: October 2018

BackgroundThere is abundant evidence to indicate that HBXIP functions as an oncoprotein and transcription co‐activator during the development and promotion of cancers. In multiple cancers, ZEB1 serves as a transcription activator to regulate gene expression. We explored the roles of ZEB1 in HBXIP‐induced breast cancer growth.MethodsHBXIP regulation of ZEB1 was evaluated by reverse transcription PCR and immunoblotting. The stimulation of ZEB1 promoter by HBXIP and/or Sp1 was tested using luciferase reporter gene analysis. The alteration of cell proliferation mediated by HBXIP‐induced ZEB1 was tested using methyl‐thiazolyl‐tetrazolium and 5‐Ethynyl‐2′‐deoxyuridine (EdU) incorporation analysis. ZEB1 and HBXIP expression in human breast cancer tissues was analyzed using quantitative real‐time PCR. The relationship between HBXIP and ZEB1 was confirmed by Pearson's correlation coefficient.ResultsWe observed dose‐dependent upregulation of ZEB1 by HBXIP in breast cancer cells. HBXIP can activate the ZEB1 promoter by interacting with transcription factor Sp1. Cell viability and EdU incorporation analysis showed that HBXIP could drive cell proliferation by enhancing ZEB1 in breast cancer. Using quantitative real‐time PCR, ZEB1 overexpression and a positive relationship between ZEB1 and HBXIP were observed in clinical breast cancer samples.ConclusionOncogenic HBXIP controls the transcription regulation of ZEB1 by co‐activating Sp1, thereby accelerating breast cancer growth.
LRH1 as a promising prognostic biomarker and predictor of metastasis in patients with non‐small cell lung cancer
Authors: Liu Yuechao , Xing Ying , Wang Hongmei , Yan Shi , Wang Xinzhu , Cai Li 
Published: October 2018

BackgroundLRH1, which promotes the malignant transformation of carcinoma, has recently been documented in several types of malignancies. However, LRH1 has not been assessed as a potential clinical biomarker in any cancer.MethodsLRH1 expression was tested in fresh‐frozen tissue samples with quantitative real‐time PCR and Western blot analysis. Surgically resected tumor tissues were collected from 156 non‐small cell lung cancer (NSCLC) patients: 75 with adenocarcinoma and 81 with squamous cell carcinoma. Subsequently, the immunohistochemical expression of LRH1 was examined, and its clinical significance was evaluated.ResultsLRH1 overexpression was observed in NSCLC carcinoma tissues compared to adjacent normal lung tissues. LRH1 expression was correlated with poorer differentiation (P = 0.023), pathological tumor classification (P < 0.001), advanced pathological tumor node metastasis stage (P = 0.017), adenocarcinoma subtype (P = 0.031), and positive lymph node metastasis (P < 0.001). Multivariate analysis demonstrated that LRH1 expression status was an independent prognostic factor for overall (hazard ratio 1.372, 95% confidence interval 1.225–1.617; P = 0.003) and disease‐free survival (hazard ratio 1.497, 95% confidence interval 1.059–2.115; P = 0.011) in patients who suffered from resectable NSCLC.ConclusionThe results of our study indicate that LRH1 predicts NSCLC progression, metastasis, and a dismal prognosis, emphasizing its promising role as a novel target in NSCLC therapies.
The Maudsley Staging Method as predictor of electroconvulsive therapy effectiveness in depression
Authors: van Diermen Linda , Hebbrecht Kaat , Schrijvers Didier , Sabbe Bernard C. G. , Fransen Erik , Birkenhäger Tom K. 
Published: October 2018

ObjectiveTo investigate the potential role of the Maudsley Staging Method (MSM) in the prediction of electroconvulsive therapy (ECT) outcome in severely depressed adults.MethodBetween August 2015 and August 2017, 73 consecutive patients with a major depressive episode (DSM‐IV‐TR) scheduled for ECT were recruited. Prior to their first ECT session, the MSM was completed to assess the level of therapy resistance. To determine the reduction in depression severity and response and remission rates, symptom severity was assessed at baseline and within one week after the last ECT session using the 17‐item Hamilton Depression Rating Scale (HDRS17).ResultsThe percentage of symptom reduction following ECT was best predicted by the MSM episode duration and depression severity factors (R2 completer sample 0.24). Episode duration alone was the best predictor of remission (area under the ROC curve for completers: 0.72). Adding age to the models increased their predictive capacity.ConclusionAn adapted version of the MSM gauging shorter episode duration, more severe depressive symptoms and older age is significantly associated with ECT effectiveness in adults with severe recurrent depression and is thus highly suitable for use in clinical practice, promoting the shared treatment decision‐making process.
Effect on the mechanical properties of human and bovine dentine of intracanal medicaments and irrigants
Authors: Cochrane S , Burrow MF , Parashos P 
Published: October 2018

AbstractBackgroundEvidence is lacking concerning the suitability of using bovine dentine in endodontic research. This study compared the mechanical properties of human and bovine root dentine using endodontic medicaments and irrigants.MethodsStandardized human and bovine dentine bars were allocated to six experimental groups (n = 15): calcium hydroxide paste (Calasept® Plus); Odontopaste®; 0.5% and 1% NaOCl gels; 1% and 4% NaOCl solutions. The bars were exposed to the materials for 7 days and then immediately subjected to a three‐point bend test and Vickers microhardness test. Data were analysed using analysis of variance with Fisher's pairwise comparisons, with P < 0.05.ResultsHuman dentine displayed a significantly higher modulus of elasticity (P = 0.001), higher microhardness (P < 0.001), and lower flexural strength (P = 0.004) compared with bovine dentine. Calcium hydroxide and Odontopaste® did not result in a significant change to the mechanical properties of human dentine. In human dentine, 0.5% NaOCl gel caused a significant decrease in flexural strength (P < 0.001) and microhardness (P = 0.02).ConclusionsBovine dentine was a suitable substrate relative to human dentine. The use of a 0.5% or 1% NaOCl gel as an intracanal medicament is not supported by this study.
National and subnational mortality of urological cancers in Iran, 1990–2015
Authors: Pishgar Farhad , Amini Erfan , Gohari Kimiya , Aminorroaya Arya , Sheidaei Ali , Rostamabadi Yasna , Ebrahimi Hooman , Yoosefi Moein , Naderimagham Shohreh , Rezaei Nazila , Modirian Mitra , Namazi Shabestari Alireza , Kompani Farzad , Farzadfar Farshad 
Published: October 2018

AbstractPurposeTo study trends of urological cancers mortalities in Iran between 1990 and 2015 as a part of a larger project named national and subnational burden of diseases, injuries, and risk factors.MethodsThe primary dataset of this project comprises data of national death registration system. Cause‐specific mortality fraction for each age, sex, province, and year group was calculated using a two‐stage mixed effects and spatiotemporal models, and then these fractions were applied to all‐cause mortality rates, obtained from a parallel study to estimate mortality rates attributable to each cause.ResultsIn 2015, urological cancers constituted 8% of cancer‐related deaths in Iran, and number of deaths due to prostate, bladder, testicular, and kidney and other urinary organs cancers were estimated as 2,128 (1,565–2,891), 297 (230–385), 301 (144–639), and 195 (143–267), respectively. Our estimates show that age‐standardized death rates (ASDRs) of these cancers reached 6.8 (5–9.23), 0.47 (0.37–0.61), 0.96 (0.46–2.04), and 0.24 (0.18–0.33) deaths per 100,000 individuals in 2015, a reduction in the three latter cancers, from 4.09 (2.92–5.76), 13.04 (10.04–16.95), 1.23 (0.46–3.34), and 1.76 (1.28–2.42) deaths per 100,000 individuals in 1990, respectively.ConclusionsIn conclusion, despite disparities among different provinces, overall mortality rate of urological cancers decreased significantly since 1990s in Iran.
The impact and indications for Oncotype DX on adjuvant treatment recommendations when third‐party funding is unavailable
Authors: Chin‐Lenn L. , De Boer R. H. , Segelov E. , Marx G. M. , Hughes T. M. , McCarthy N. J. , White S. C. , Foo S. S. , Rutovitz J. J. , Della‐Fiorentina S. , Jennens R. , Antill Y. C. , Tsoi D. , Cronk M. F. , Lombard J. M. , Kiely B. E. , Chirgwin J. H. , Gorelik A. , Mann G. B. 
Published: October 2018

AbstractObjectivesIndustry‐supported decision impact studies demonstrate that Oncotype Dx (ODX) changes treatment recommendations (TR) in 24–40% of hormone receptor+/HER2− patients. ODX is not reimbursed by third‐party payers in Australia, potentially resulting in more selective use. We sought to evaluate the impact of self‐funded ODX on TRs.MethodsData collected included demographics, tumor characteristics, indication for ODX and pre‐ and post‐recurrence score (RS) TR. Primary endpoint was frequency of TR change and associations with TR change were sought.ResultsEighteen physicians contributed 382 patients (median age 54). A total of 232 (61%) of tumors were T1 and were grade 1, 2 and 3 in 49 (13%), 252 (66%) and 79 (21%). A total of 257 (67%) were node negative. Assay indications were: confirm need for chemotherapy (CT) (36%), confirm omission of CT (40%) and genuine equipoise (24%). RS was low (≤17) in 55%, intermediate (18‐31) in 36% and high (≥32) in 9%. Thirty‐eight percent of patients had TR change post‐ODX. Sixty‐five percent of patients recommended CT pre‐ODX changed to hormone therapy alone (HT)—more likely if lower grade and if ER and/or PR > 10%. Fourteen percent of patients with pre‐ODX TR for HT added CT—more likely if ER and/or PR ≤10% and if Ki67 > 15% Overall, TR for CT decreased from 47% to 24%.ConclusionPatient‐funded ODX changed TRs in 38% of patients, de‐escalating 65% from CT to HT and adding CT to 14% of those recommended HT. These changes were greater than an industry‐funded study suggesting that physicians can identify situations where the assay may influence decisions.
The prognostic significance of the expression of monocarboxylate transporter 4 in patients with right‐ or left‐sided colorectal cancer
Authors: Abe Yukio , Nakayama Yoshifumi , Katsuki Takefumi , Inoue Yuzuru , Minagawa Noritaka , Torigoe Takayuki , Higure Aiichiro , Sako Tatsuhiko , Nagata Naoki , Hirata Keiji 
Published: October 2018

AbstractAimMonocarboxylate transporter 4 (MCT4) is a proton pump that exchanges lactate through the plasma membrane. The present study investigated the clinical significance of the expression of MCT4 in patients with right‐ or left‐sided colorectal cancer (CRC).MethodsSurgical specimens from 237 CRC patients were immunohistochemically stained with polyclonal anti‐MCT4 antibodies. The relationships among the MCT4 expression, the clinicopathological factors, and the prognosis were evaluated.ResultsThirty‐six (62.1%) of 58 patients with right‐sided CRC and 95 (53.1%) of 179 patients with left‐sided CRC showed the high expression of MCT4. The MCT4 expression was significantly correlated with gender and lymph node metastasis in patients with right‐sided CRC, and size, depth of invasion, distant metastasis, and tumor‐node‐metastasis stage in patients with left‐sided CRC. A univariate analysis demonstrated that the expression of MCT4 was a significant prognostic factor in both right‐ and left‐sided CRC patients. A multivariate analysis demonstrated the expression of MCT4 was a significantly independent prognostic factor in patients with left‐sided CRC, but not in those with right‐sided CRC.ConclusionsOur results suggest that the high expression of MCT4 is a useful marker for tumor progression and a poor prognosis in CRC patients, especially those with left‐sided CRC.
Influence of termites on the soil seed bank in an African savannah
Authors: Masocha Mhosisi , Dube Timothy 
Published: October 2018

AbstractIn savannah ecosystems, termites drive key ecosystem processes, such as primary production through creation of patchiness in soil nutrients availability around their nests. In this study, we evaluated the role of termites in altering the soil seed bank size, an important ecosystem component that has often been overlooked in previous work. Data on above ground vegetation and soil seed bank samples were collected from four microhabitats, that is, the wooded mound, unwooded mound, tree sub‐canopy and the open grassland matrix in a protected game reserve in south‐central Zimbabwe. The seedling emergence method was then used to identify species present in the soil samples. One‐way analysis of variance followed by Tukey's multiple comparison tests was executed to test for significant differences in plant species richness among the four microhabitats. The results indicate that plant species richness was high on wooded termite mound but did not differ between the unwooded and the sub‐canopy microhabitats. The open grassland microhabitat had the lowest plant species richness. The influence of termites on the soil seed bank composition was also life form specific. The herb and woody life forms had significantly (α = 0.05) higher species richness in the soil seed bank at wooded and unwooded termite mounds when compared to the other two microhabitats. Overall, these results imply that termites alter the soil seed bank and the findings enhance our understanding of the significant role termites play in regulating processes in savannah ecosystem.
“An opportunity to hope and dream”: Disaster Politics and the Emergence of Possibility through Community‐Led Recovery
Authors: Cretney Raven 
Published: October 2018

AbstractRecent awareness of the role of neoliberalism in fostering tactics of de‐politicisation has cultivated recognition of a narrowing of democratic possibilities. Disaster, as a time of disruption can provoke a heightened awareness of dynamics of power and contestation. This provides a fertile ground to understand the possibility for de‐politicisation alongside that of resistance and hope. This paper weaves together and contextualises these ideas within a case study of community‐led disaster recovery in the city of Ōtautahi Christchurch in Aotearoa New Zealand following a series of devastating earthquakes in 2010 and 2011. In exploring the entangled relationship between crisis and hope I discuss how forms of de‐politicisation can emerge in the disaster context as well as the resistance that also emerges at the grassroots and everyday scale. I emphasise the need to see post politics as present‐yet‐incomplete alongside the potential for participatory and radical forms of social change at the grassroots scale.
Children and Adults Selectively Attribute Shared Cultural Knowledge to Speakers of the Same Language
Authors: Soley Gaye , Aldan Pınar 
Published: October 2018

Children's and adults’ attributions of shared knowledge of and shared preference for songs were investigated across two prominent social categories: language and gender. Both attributions indicate similarity among individuals but shared cultural knowledge can be more informative about common social history than shared preference, as it is mainly transferred through social interactions within cultures, while preferences can have various sources. Both 5‐ to 6‐year‐old children (N = 60) and adults (N = 160) generalized knowledge of songs across individuals who speak the same‐language rather than same‐gender individuals. In contrast, preference for songs was not systematically generalized across either category. Thus, individuals selectively infer shared cultural knowledge among same‐language speakers, suggesting an early emerging link between shared knowledge and cultural boundaries.
Does studying abroad enhance employability?
Authors: Liwiński Jacek 
Published: October 2018

AbstractOver 200,000 European students study abroad under the Erasmus programme. It appears that studying abroad may impart skills which are helpful for professional careers after graduation. Approximately, 54% of European students report that participation in the Erasmus exchange programme helped them to obtain a first job; however, interestingly, those from Central and Eastern European countries report it much more often—in 73% of cases. The aim of this paper is to find out whether studying abroad enhances the employability of higher education graduates in Poland. Using the propensity score matching method and data from a nationwide tracer survey of Polish graduates, we find that Polish students who completed at least one semester of their studies abroad do not benefit in terms of a higher employment rate after graduation.
Seasonal migration and fine‐scale movement of invasive round goby (Neogobius melanostomus) in a Great Lakes tributary
Authors: Blair Scott G. , May Chelsea , Morrison Brian , Fox Michael G. 
Published: October 2018

AbstractTo determine whether invasive round goby (Neogobius melanostomus) from Lake Ontario were establishing a year‐round population in a tributary stream or migrating to the lake, we assessed population and individual movement patterns using mark–recapture assessment generated from weekly backpack electrofishing from May until November 2016. Round goby abundance was low in spring, peaked in summer and decreased again in autumn, suggesting seasonal inward stream migration and outward migration back to the lake. Adult round goby movement patterns were positively associated with changes in water temperature, but this was not the case for juveniles. Juveniles displayed a preference for shallow, upstream habitats. Observations of reproductive individuals coupled with a peak in juvenile abundance following the peak in adult abundance indicate that the tributary was used for reproduction and recruitment. The individual movement was primarily upstream in spring, and there was little net movement in summer, likely during reproduction. Downstream movement occurred in autumn over a short time period, suggesting rapid outmigration to the lake. The combined observations of seasonal population structure and individual movement suggest that tributary streams connected to large, infested waterbodies can be used for round goby reproduction and recruitment, rather than year‐round residence. This study provides evidence of round goby seasonal migration and their individual movement patterns within tributary streams, which complements an earlier study in Lake Erie tributaries and may be a common occurrence in other Great Lakes tributaries.