bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms
Authors: Roque‐Borda Cesar Augusto , Primo Laura Maria Duran Gleriani , Medina‐Alarcón Kaila Petronila , Campos Isabella C. , Nascimento Camila de Fátima , Saraiva Mauro M. S. , Berchieri Junior Angelo , Fusco‐Almeida Ana Marisa , Mendes‐Giannini Maria José Soares , Perdigão João , Pavan Fernando Rogério , Albericio Fernando 
Published: November 2024

AbstractPolymicrobial biofilms adhere to surfaces and enhance pathogen resistance to conventional treatments, significantly contributing to chronic infections in the respiratory tract, oral cavity, chronic wounds, and on medical devices. This review examines antimicrobial peptides (AMPs) as a promising alternative to traditional antibiotics for treating biofilm‐associated infections. AMPs, which can be produced as part of the innate immune response or synthesized therapeutically, have broad‐spectrum antimicrobial activity, often disrupting microbial cell membranes and causing cell death. Many specifically target negatively charged bacterial membranes, unlike host cell membranes. Research shows AMPs effectively inhibit and disrupt polymicrobial biofilms and can enhance conventional antibiotics' efficacy. Preclinical and clinical research is advancing, with animal studies and clinical trials showing promise against multidrug‐resistant bacteria and fungi. Numerous patents indicate increasing interest in AMPs. However, challenges such as peptide stability, potential cytotoxicity, and high production costs must be addressed. Ongoing research focuses on optimizing AMP structures, enhancing stability, and developing cost‐effective production methods. In summary, AMPs offer a novel approach to combating biofilm‐associated infections, with their unique mechanisms and synergistic potential with existing antibiotics positioning them as promising candidates for future treatments.
Tuning the Magnetism in Ultrathin CrxTey Films by Lattice Dimensionality
Authors: Miao Guangyao , Gu Minghui , Sun Haojie , Chen Pan , Li Jiade , Xue Siwei , Su Nuoyu , Su Zhibin , Zhong Weiliang , Zhang Zhihan , Zhu Xuetao , Zhang Jiandi , Yao Yugui , Jiang Wei , Meng Meng , Wang Weihua , Guo Jiandong 
Published: November 2024

Abstract2D magnetic crystals with atomic thickness exhibit intriguing physical properties, which have attracted considerable research interest in the related materials’ family, both in fundamental research and in developing spintronic devices. The recent discovery of some non‐van der Waals 2D magnetic crystals expands the systems. Nevertheless, the relationship between the dimensionality of microscopic magnetic exchange interactions and macroscopic magnetic properties at the 2D limit remains to be fully elucidated. Here, we have fabricated mono‐phased continuous ultrathin CrTe2 and Cr3Te4 films by molecular beam epitaxy and elucidated the diverse magnetism tuned by the dimensionality of exchange interactions by a joint study of spin‐polarized scanning tunneling microscopy, magnetization, magneto‐transport measurements, and density functional theory calculations. The transition from a zigzag‐antiferromagnetic order in the monolayer CrTe2 to a ferromagnetic (FM) order in the second‐layer CrTe2 is confirmed, which is driven by their varied in‐plane lattice constants induced change of 2D exchange interactions. A robust FM state with large perpendicular magnetic anisotropy in Cr3Te4 is observed, originating from its strong 3D exchange interactions. The observed evolution of magnetism demonstrates that the dimensionality of magnetic exchange interactions strongly influences magnetism even at the 2D limit.
Fingerprinting‐Based Indoor Localization in a 3 × 3 Meter Grid Using OFDM Signals at Sub‐6 GHz
Authors: Kaur Jaspreet , Tan Kang , Khan Muhammad Z. , Popoola Olaoluwa R. , Imran Muhammad A. , Abbasi Qammer H. , Abbas Hasan T. 
Published: November 2024

ABSTRACTAccurately determining the indoor location of mobile devices has garnered significant interest due to the complex challenges posed by non‐line‐of‐sight (NLOS) propagation and multipath effects. To address this challenge, this paper proposes a new approach to indoor positioning that utilises channel state information (CSI) and machine learning (ML) techniques to improve accuracy. The proposed method extracts the amplitude and phase differences of the subcarriers from the CSI data to create fingerprints. ML algorithms and network architecture are utilised to train the CSI data from two antennas, in the form of phase and amplitude. Experiments conducted in a standard indoor environment demonstrate the effectiveness of the proposed method.
Development of a hamster model of spontaneous hypertriglyceridemia in diabetes
Authors: Ma Ya‐Hong , Wang Yuhui , Liu George 
Published: November 2024

AbstractHypertriglyceridemia (HTG) often accompanies diabetes and is considered a risk factor for diabetic vascular complications. However, inducing diabetic HTG typically requires high‐fat diets in certain animal models. Leveraging our newly developed LDL receptor knockout hamster model, which exhibits features akin to human lipid metabolism, we sought to determine whether these animals would develop HTG without dietary manipulations in diabetes. Diabetes was induced via intraperitoneal injection of STZ in wild type and heterozygous LDL receptor deficient hamsters. Blood glucose, triglyceride, and cholesterol were measured over 60 days. Plasma TG clearance was determined via olive oil gavage. The effect of insulin on diabetic HTG was assessed on Day 60 post‐diabetes induction. Blood glucose increased over threefold, while plasma insulin decreased to 30% of controls after STZ injection in both wild type and heterozygous hamsters by Day 7, remaining stable for 60 days. Plasma TG in wild‐type hamsters remained unchanged at Day 7 post‐STZ injection but increased slightly thereafter. Conversely, heterozygous hamsters exhibited severe HTG by Day 7 until the end of the study. Olive oil gavage revealed much slower plasma triglyceride clearance in heterozygous hamsters compared to WT animals, despite significantly reduced lipoprotein lipase activity in post‐heparin plasma in both animals. Hyperglycemia and HTG in heterozygous hamsters were reversed to pre‐diabetic levels following intraperitoneal insulin administration. In conclusion, severe HTG in diabetic heterozygous LDL receptor deficient hamsters developed spontaneously and was insulin‐dependent. Thus, this hamster model holds promise for effectively studying the complications associated with human diabetic HTG.
Escape from Flatland: Stereoselective Synthesis of Hexa‐aryl Borazines and their sp²‐Based 3D Architectures
Authors: Wakchaure Vivek C , Lorenzo-García Maria Mercedes , Fasano Francesco , Crosta Martina , Biot Nicolas , Mondal Pradip Kumar , Demitri Nicola , Ward Benjamin , Bonifazi Davide 
Published: November 2024

Borazine and its derivatives can be considered critical doping units for engineering hybrid C(sp2)‐based molecules with tailored optoelectronic properties. Herein, we report the first synthesis of hexaarylborazines that, bearing ortho‐substituted aryl moieties, extend three‐dimensionally. Using a one‐pot protocol, we first form an electrophilic chloroborazole and then react it with an aryl lithium (ArLi). By selecting the appropriate ortho‐substituent, we can guide the ArLi to add to the BN‐core in a specific way, ultimately controlling the stereochemical outcome of the three‐substitution reaction. Rationalization of the stereochemical model through computational analysis allowed us to show that when aryl lithium nucleophiles bearing rigid long‐range ortho‐substituents are used, i.e., stiff substituents. The ortho‐substituent shields its side of the electrophilic B3N3 core, biasing the incoming ArLi to add anti at each addition step, forming the final tri‐aryl borazine exclusively as cc‐isomer. Leveraging this stereoselective approach, prototypical multichromophoric borazine derivatives were prepared, and we showcased how the stereochemical arrangement of these chromophores distinctly influences their redox behavior. This methodology paves the way for previously inaccessible borazines to serve as privileged precursors to transcend the conventional bidimensionality associated with graphenoid systems and pioneer the construction of new forms of three‐dimensional C(sp2)‐based architectures.
Supramolecular Co (II) Complex Fabricated From Adenine Derivative: Synthesis, Crystal Structure, Hirshfeld Surface, DFT Optimization, Anticancer, and Molecular Docking Studies
Authors: Nath Sourav , Sen Tanushree , Roy Sourav , Baildya Nabajyoti , Borah Pranab , Kaminsky Werner , Gargari Masoumeh Servati , Verma Akalesh Kumar , Kanmazalp Sibel Demir , Adhikari Suman , Saha Indrajit 
Published: November 2024

ABSTRACTThis article presents the synthesis of a novel mononuclear Co (II) complex [Co(9‐BuA)2Cl2] (1), its characterization, supramolecular packing pattern, theoretical calculations, anticancer properties, and molecular docking studies. Complex 1 was generated from 9‐butyl adenine (9‐BuA) building block and characterized by spectroscopic methods (FT‐IR, mass, elemental analysis) and single crystal X‐ray diffraction analysis. The cobalt (II) ion in complex 1 is distorted in its tetrahedral environment. The Co+2 is coordinated to the two rare N1 binding sites of the pyrimidinate moiety of two 9‐BuA ligands and two chlorine atoms occupying the axial positions. Both intramolecular and intermolecular hydrogen bonds support the formation of supramolecular assembly and stabilize the crystal structure. The nature of the intermolecular interactions in the supramolecular network was also decoded by Hirshfeld surface analysis and molecular surface contours (dnorm). The percentage contributions are represented by 2D fingerprint plots. The average energy between dimers was determined by the energy framework analysis, and the crystal packing's three‐dimensional topology was also investigated. Density functional theory (DFT) has been used to ascertain the geometry and interactions in the complex. The cytotoxic effects of Co (II) complex 1 and corresponding 9‐BuA ligand were investigated in Dalton's lymphoma (DL) malignant cancer cells and on normal peripheral blood mononuclear cells (PBMCs) to evaluate their anticancer activity. Finally, molecular docking analyses have been carried out to analyze the nature of molecular interactions between Co (II) complex 1 and the receptor.
A facile and sustainable preparation of effective biomass macromolecular flame retardants for epoxy resins with improved flame retardation, smoke suppression, and mechanical performance
Authors: Ling Chao , Zhang Wen , Wang Zhengzhou 
Published: November 2024

AbstractThe preparation of biomass flame retardants with efficient flame‐retardant properties is conducive to the realization of sustainable development and is of great practical significance. In this work, a green and sustainable biomass flame retardant PATAPEI was prepared by using phytic acid (PA), tannic acid (TA), and polyethyleneimine (PEI) as reactants via a one‐step method to develop biomass flame retardants that can synchronize enhanced flame retardation, smoke suppression, and mechanical performance of epoxy resin (EP). The EP with only a 3% PATAPEI (EP/3PTP) has a LOI value of 28.5% with a UL‐94 V‐0 classification. The peak heat release rate (PHRR), total heat release (THR), and total smoke release (TSR) of EP/3PTP were decreased by 29.72%, 25.80%, and 21.16%, respectively, in comparison with the ones of pure EP. Additionally, the tensile and impact strengths of EP/3PTP are higher than the ones of pure EP. PATAPEI on heating decomposes to produce phosphorus‐containing acids and biphenyltriol‐containing compounds, which promote to form a good char layer with the aromatic structures during the combustion of EP/3PTP. Therefore, PATAPEI has prospects of wide application in the development of sustainable biomass flame retardant EP.
High‐strength silicone polyurea/DOCIT coating with anti‐biofouling and self‐healing characteristics
Authors: Ge Jian , Li Mei , Wang Rutian , Zhang Yunqiang , Jing Laiying , Cui Jiaxi 
Published: November 2024

AbstractA new organosilicon‐based polyurea/DOCIT composite coating with excellent mechanical, self‐healing characteristics has been successfully prepared in this paper. The optimal ratio of the two isocyanates has been explored to acquire the highest mechanical strength with 8.56 MPa and best tensile properties with 763%. The breaking strength and elongation remain 3.50 MPa and 915% with 1% antimicrobial agent DOCIT. The self‐healing characteristic comes from dense hydrogen and dynamic disulfide bonds between molecule chains. The composite coating exhibited ideal bacterial resistances for 98.02% and 96.75% against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), respectively. The adhesion of chlorella was significantly reduced by approximately 86.48%. This work provides a promising avenue for the development of high‐performance silicone polyurea coatings for marine anti‐biofouling.
From phylogenomics to breeding: Can universal target capture probes be used in the development of SNP markers for kinship analysis?
Authors: Ousmael Kedra M. , Hansen Ole K. 
Published: November 2024

AbstractPremiseLeveraging DNA markers, particularly single‐nucleotide polymorphisms (SNPs), in parentage analysis, sib‐ship reconstruction, and genomic relatedness analysis can enhance plant breeding efficiency. However, the limited availability of genomic information, confined to the most commonly used species, hinders the broader application of SNPs in species of lower economic interest (e.g., most tree species). We explored the possibility of using universal target capture probes, namely Angiosperms353, to identify SNPs and assess their effectiveness in genomic relatedness analysis.MethodsWe tested the approach in 11 tree species, six of which had a half‐sib family structure. Variants were called within species, and genomic relatedness analysis was conducted in species with two or more families. Scalability via amplicon sequencing was tested by designing primers and testing them in silico.ResultsAdequate SNPs for relatedness analysis were identified in all species. Relatedness values from Angiosperms353‐based SNPs highly correlated with those from thousands of genome‐wide DArTseq SNPs in Cordia africana, one of the species with a family structure. The in silico performance of designed primers demonstrated the potential for scaling up via amplicon sequencing.DiscussionUtilizing universal target capture probes for SNP identification can help overcome the limitations of genomic information availability, thereby enhancing the application of genomic markers in breeding plant species with lower economic interest.
Homobimetallic Ruthenium(II) Complexes Catalysed Selective Transfer Hydrogenation of Aldehydes in Water
Authors: Deshmukh Gopal , Rana Thakur Rochak Kumar , Rajaraman Gopalan , Murugavel Ramaswamy 
Published: November 2024

AbstractHerein we report chemoselective transfer hydrogenation (TH) of aldehydes in aqueous medium using a series of homobimetallic Ru(II) catalysts. Two homobimetallic complexes (Ru1 and Ru3) and one monometallic complex (Ru2) have been employed in the catalytic reduction of aldehydes. Bimetallic complex [(p‐cymene)2(RuCl)2L3] (Ru3) is obtained from the reaction of Schiff base ligand 2,2′‐((1E,1′E)‐((3,3′,5,5′‐tetraisopropyl‐[1,1′‐biphenyl]‐4,4′diyl)bis(azaneylylidene))bis(methaneylylidene))bis(4‐bromophenol) (H2L3) and characterized by various spectroscopic and analytical techniques. The use of formic acid/formate buffer as the hydride source and a catalyst loading of 0.01 mol % of Ru1 or Ru3 resulted in the conversion of various aldehydes to the corresponding alcohols in good to excellent yield. This method is very efficient for selective reduction of aldehydes in the presence of other reducible functional groups. A loading of 0.0001 mol % of Ru1 catalyst is sufficient to achieve a turnover frequency (TOF) of 5.5×105 h−1. Furthermore, the catalyst can been recycled and reused for six consecutives cycles without sacrificing the efficiency. A comparison of results obtained between bimetallic and monometallic complexes offers valuable insights into the distinct reactivity patterns of the bimetallic complexes, presumably originating from a cooperative effect. To understand the detailed mechanism, we have explored the mechanistic pathway using DFT methods on reported catalysts and various models which indicate that addition of aldehyde as rate‐limiting and presence of cooperativity that boost the catalytic efficiency in the case of dinuclear Ru1 catalyst. The pH dependent TH mechanism has been investigated with the aid of NMR and ESI‐MS spectroscopic techniques.
Schiff Base Mediated Synthesis of Novel Imidazolidine‐4‐One Derivatives for Potential Antimicrobial and Anthelmintic Activities
Authors: Chilamakuru Naresh Babu , Singirisetty Triveni , Bodapati Anoop , Kallam Sudha Divya Madhuri , Nelson Vinod Kumar , Suryadevara Punna Rao , Thangaswamy Selvankumar 
Published: November 2024

ABSTRACTThis study focuses on developing novel antimicrobials to combat drug‐resistant pathogens, addressing compounds failing clinical trials due to inadequate physicochemical properties. Sixteen imidazolidine‐4‐one derivatives were synthesized by extensive evaluation using molecular docking, absorption, distribution, metabolism, excretion (ADME) predictions, and antimicrobial testing. Molecular docking studies conducted with Schrödinger's Glide revealed that compounds S4 and G8 exhibited superior docking scores of −7.839 and −7.776, respectively. The G series outperformed the S series in scores. ADME analysis confirmed all compounds adhered to Lipinski's rule of five. In addition, IR and NMR provided details about the structure of the compounds. Antimicrobial activity was assessed against Escherichia coli, Staphylococcus aureus, and Candida albicans, with compounds G2 and S2 showing exceptional minimum inhibitory concentration (MIC) values of 6.25 μg/mL against E. coli. S2 also demonstrated impressive activity against S. aureus (MIC 3.12 μg/mL), and S4 exhibited potent activity against C. albicans (MIC 0.8 μg/mL) than fluconazole (1.6 μg/mL). Additionally, antihelmintic activity was evaluated, with G1, G3, G8, S2, S4, S7, and S8 showing effective paralysis and death time 20 min and below at 50 mg/mL concentration. These results underscore the potential of new imidazolidine‐4‐one derivatives as suitable sources to develop a drug candidate to treat resistant infections.
Metaverse Metamorphosis: Fintech's Evolution Catalyzing New Era of Consumer Behavior
Authors: Dutta Antora , Singh Saumya 
Published: November 2024

ABSTRACTAll facets of society may enter the virtual world more quickly due to the rapid development of digital technology, which would blur the boundary between the real and the digital realms and encourage the creation of a Metaverse. In the upcoming decades, metaverse technology—which allows immersive experiences in virtual and real environments—will be the next revolutionary force in society. The Fintech industry has been one of the first to adopt it, and it is one of those that uses technology to resolve problems. The study begins by conceptualizing the Metaverse as being defined explicitly by the convergence of its essential components and its influence on the fintech sector. It further discusses how Metaverse could create value in consumer behaviour in three vicinities: social perception, user identity and advertising & consumer psychology. Finally, the study presents the various implications and future scope of this research by doing the thematic analysis to enhance our understanding of the Metaverse economy and how it influences consumer behaviour. This study provides an overview of the shift occurring in the marketplace and contemplates the various changes that it may bring, all through the perspective of consumer behaviour which can be used to create predictive models that recognize emerging trends in customer behaviour, market activities, and other aspects of the business.
Blockchain in Luxury Resale: The Impact of Blockchain Technology Through Regulatory Focus and Uncertainty Reduction Theories
Authors: Swazan Ishtehar Sharif , Youn Song‐yi 
Published: November 2024

ABSTRACTThe exponential growth of the online luxury resale market has spurred a notable shift toward a circular economy, reflecting the increasing consumer preference for pre‐owned luxury items. Nevertheless, this growth presents challenges related to product authenticity and seller credibility. In response to these concerns, blockchain technology (BT) emerges as a promising solution, leveraging a decentralized ledger to enhance transparency and reduce information asymmetry. This allows for the traceability of pre‐owned luxury goods, addressing issues of provenance and authenticity in the online resale space. By incorporating regulatory focus theory into the uncertainty reduction theory, this study examines how approach and avoidance motivations impact evaluations of BT‐enabled platforms to effectively mitigate consumer uncertainties and influence trust. The collected data (N= 511) was analyzed through partial least squares structural equation modeling (PLS‐SEM; study 1), and a complementary qualitative study (study 2) was additionally conducted. Results reveal that distinct motivations coexist, each following separate pathways to build consumer trust. Findings indicate that an approach orientation mindset highly values the reliability of BT‐enabled information, while an avoidance orientation focuses on risk mitigation and expresses heightened uncertainty in online transactions. Consequently, BT is found to be instrumental in reducing consumer concerns about purchasing pre‐owned luxury products. The study contributes to the existing literature by shedding light on the psychological dynamics influencing consumer trust in BT‐enabled platforms, has implications for luxury retailers contemplating BT integration, and offers insights into consumer behavior that can inform strategies to enhance perceived trust in online luxury resale.
Benzylidenehydrazine Derivatives: Synthesis, Antidiabetic Evaluation, Antioxidation, Mode of Inhibition, DFT and Molecular Docking Studies
Authors: Seboletswe Pule , Kumar Gobind , Gcabashe Nontobeko , Olofinsan Kolawole , Islam Shahidul , Idris ALmahi , Singh Parvesh 
Published: November 2024

AbstractDiabetes mellitus (DM) is a metabolic condition that is a profound health concern across the globe due to its contribution to the increased mortality rate. It affects millions of people around the world and is associated with severe complications among people diagnosed with it. Among the array of approaches used for the management of DM, inhibition of enzymes viz. α‐amylase and α‐glucosidase which are responsible for sugars hydrolysis is regarded as a feasible therapeutic protocol for the management of DM. Herein, we report the synthesis of benzylidenehydrazine derivatives as well as their evaluation as α‐glucosidase and α‐amylase inhibitors including their antioxidant testing. Generally, all the synthesized derivatives were more potent inhibitors of α‐amylase than of α‐glucosidase. Specifically, 2,4 fluoro substituted analogue 9 (IC50 =116.19 μM) emerged as the strongest α‐amylase inhibitor with ~5‐fold superior activity in comparison to the standard drug, acarbose (IC50 =600 μM). Compounds 18 (IC50 =240.59) and 19 (IC50 =198.32 μM) displayed the strongest NO scavenging activity compared to Trolox (IC50 =272.36 μM). In addition, the enzyme kinetic studies indicated that compound 9 acts as a non‐competitive inhibitor of α‐amylase. Finally, density functional theory and molecular docking studies for compound 9 were conducted to explore its structural and electronic properties as well as to determine protein‐ligand interactions, respectively to decipher its observed activity. The obtained findings present promising possibilities for developing new drug candidates to control postprandial glucose levels in persons with diabetes.