bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perception de l’usabilité des outils d’innovation : le biais du genre dans l’utilisation du business model canvas
Authors: Lima Marcos , Baudier Patricia , Boufaden Najoua 
Published: September 2018

Peu d’études ont porté sur l’impact du genre dans l’usabilité des outils d’innovation. Cet article analyse l’expérience d’utilisation du Business Model Canvas (BMC) par 204 étudiants inscrits à une formation entrepreneuriale afin d’identifier les bénéfices perçus du BMC en prenant en compte le genre. L’analyse des données avec la technique des Moindres Carrés (PLS) montre que les hommes sont plus sensibles aux bénéfices fonctionnels, pendant que les femmes sont ouvertes à d’autres bénéfices comme le potentiel créatif de l’outil. Ces résultats confirment l’intérêt de la diversité du genre dans les équipes d’innovation : les groupes mixtes tendraient à prendre en considération à la fois le biais masculin de la performance et le biais féminin lié aux aspects subjectifs de l’outil. Plus de diversité pourrait donc amener à une utilisation plus équilibrée des bénéfices fonctionnels et cognitifs du BMC dans les équipes innovantes et les groupes de création d’entreprises. Codes JEL : D83, L26, O33
Tous les « terroristes » sont de Majengo, à Nairobi : spatialités contestées du « terrorisme » dans les discours anti-radicalisation au Kenya
Authors: Wario Halkano Abdi , Baillot Hélène , Botiveau Raphaël 
Published: September 2018

Au Kenya, certains quartiers de Nairobi et de Mombasa sont considérés comme des espaces de radicalisation, de recrutement, de menaces terroristes. La construction délibérée de ces zones en territoires d’insécurité urbaine est un phénomène pour lequel organisations non gouvernementales, agences de donateurs et appareils de sécurité publics et privés jouent un rôle essentiel, par le biais de stratégies antiterroristes communément appelées Countering Violent Extremism (Combattre l’extrémisme violent, CVE). Prenant Majengo, un quartier pauvre de Nairobi, comme cas d’étude, cet article interroge la manière dont l’histoire de cette périphérie et sa représentation actuelle comme point chaud du « terrorisme » sont ancrées dans la planification urbaine ségréguée datant de la colonisation, les déplacements indigènes et le développement de Majengo en un lieu de prostitution, de violence de gangs urbains et d’indigence bien avant que (la guerre contre) le terrorisme n’arrive au Kenya dans les années 1990. Cet article explore la manière dont médias et acteurs institutionnels ont créé et soutenu ce récit du terrorisme. Il interroge enfin les voies par le biais desquelles les populations dites suspectes de ces quartiers tentent de renégocier et d’imaginer leurs espaces de vie quotidiens face à l’industrie des CVE qui fait de leur foyer et de leur quartier des pépinières du terrorisme.
Musiciens rebelles ou musiciens pour la paix ? Orchestrer le Mali à travers les performances musicales du conflit
Authors: Amico Marta 
Published: September 2018

Dans cet article, deux projets musicaux organisés pendant le début de l’intervention militaire française au Mali permettent de questionner la politisation des scènes musicales maliennes qui a accompagné l’éclatement du conflit armé en 2012. D’abord, il s’agit de considérer le rôle des interactions musicales dans la fabrication d’idéaux, souvent contrastés, de la paix et de la réconciliation nationale. Ensuite, les projets permettent de mieux comprendre les zones d’ombre des représentations de la paix, et notamment la place ambigüe qu’occupent les musiciens touaregs, considérés tantôt comme porte-voix des « rebelles », tantôt comme des garants du vivre ensemble national. Enfin, l’articulation de représentations ethniques, nationales et globales permet d’observer la construction de marqueurs identitaires contradictoires qui traversent la nation malienne sous l’empreinte du conflit.
Hagiographie et mise en prose au xiii e siècle. L’exemple de Barlaam et Josaphat
Authors: Lambert Adélaïde 
Published: September 2018

It is rare to find French sources in verse for lives of the Saints written in vernacular prose in the 13 th century. This study of the reworking of the anonymous version in verse of Barlaam et Josaphat focuses on the way such productions may have handled their models and integrated certain characteristics of the verse into the prose form. From the perspective of narrative economy, the quantitative relationship that the reworking of Barlaam has with its source makes it possible to determine the rewriter’s interventions and to shed light on part of the relationship between these two versions and the Latin Historia ( B.H.L. 979). Starting from the distinction between mise en prose and dérimage , this paper then focuses on the techniques used to create writing that promotes an esthetic of compromise between fidelity to the source text and intelligibility of the target text. From that perspective, rewriting becomes a process of appropriation of an earlier text as well as a literary language in development, notably in leaving the preexisting verse tradition behind.
Eco-Friendly Pharmaceutical Analysis of Multicomponent Drugs Coformulated in Different Dosage Forms Using Multivariate Curve Resolution and Partial Least Squares: A Comparative Study
Authors: Mostafa Ahmed , Shaaban Heba , Almousa Mishal , Al Sheqawi Mishal , Almousa Muntdher 
Published: September 2018

Abstract
Background: Considering the environmental impact of analytical procedures necessitates replacing the polluting analytical methods with green alternatives. Objective: This study aims to develop and validate a multivariate curve resolution–alternating least-squares (MCR-ALS) method with correlation constraint for the simultaneous determination of theophylline, ambroxol, and guaifenesin as target analytes in the presence of methylparaben and propylparaben as interfering components. In addition, a partial least-squares regression (PLSR) method was also developed andoptimized. Method: The developed methods were validated according to International Conference on Harmonization guidelines and successfully applied for the quantification of the target analytes in different pharmaceutical dosage forms. Results: Figures of merit such as root mean square error of prediction, bias, standard error of prediction, and relative error of prediction for both models were calculated, and they showedsimilar and satisfactory results. Correlation coefficients ranged between 0.9988 and 0.9992, reflectinghigh predictive ability. The optimized methods werecompared with a reported HPLC method using one-wayanalysis of variance and showed no significant difference regarding accuracy and precision. Conclusions: The proposed chemometrics methods can be used as an eco-friendly alternative for chromatographic techniques for the quality control analysis of the studied mixture in different pharmaceutical dosage forms. Highlights: An MCR-ALS model was developed. The developed model was compared with a PLSR model. Both models were validated and successfully used for the determinationof a multicomponent pharmaceutical mixture. The developed method is eco-friendly, fast, reliable, and cost-effective.
Genome‐wide identification of a novel miRNA‐based signature to predict recurrence in patients with gastric cancer
Authors: Yang Yongmei , Qu Ailin , Zhao Rui , Hua Mengmeng , Zhang Xin , Dong Zhaogang , Zheng Guixi , Pan Hongwei , Wang Hongchun , Yang Xiaoyun , Zhang Yi 
Published: September 2018

The current tumor node metastasis (TNM) staging system is inadequate for identifying high‐risk gastric cancer (GC) patients. Using a systematic and comprehensive‐biomarker discovery and validation approach, we attempted to build a microRNA (miRNA)‐recurrence classifier (MRC) to improve the prognostic prediction of GC. We identified 312 differentially expressed miRNAs in 446 GC tissues compared to 45 normal controls by analyzing high‐throughput data from The Cancer Genome Atlas (TCGA). Using a Cox regression model, we developed an 11‐miRNA signature that could successfully discriminate high‐risk patients in the training set (n = 372; P < 0.0001). Quantitative real‐time polymerase chain reaction‐based validation in an independent clinical cohort (n = 88) of formalin‐fixed paraffin‐embedded clinical GC samples showed that MRC‐derived high‐risk patients succumb to significantly poor recurrence‐free survival in GC patients (P < 0.0001). Cox and stratification analysis indicated that the prognostic value of this signature was independent of clinicopathological risk factors. Time‐dependent receiver operating characteristic (ROC) analysis revealed that the area under the curve of this signature was significantly larger than that of TNM stage in the TCGA (0.733 vs. 0.589 at 3 years, P = 0.004; 0.802 vs. 0.635 at 5 years, P = 0.005) and validation cohort (0.835 vs. 0.689 at 3 years, P = 0.003). A nomogram was constructed for clinical use, which integrated both MRC and clinical‐related variables (depth of invasion, lymph node status and distance metastasis) and did well in the calibration plots. In conclusion, this novel miRNA‐based signature is superior to currently used clinicopathological features for identifying high‐risk GC patients. It can be readily translated into clinical practice with formalin‐fixed paraffin‐embedded specimens for specific decision‐making applications.
Heterologous expression in Toxoplasma gondii reveals a topogenic signal anchor in a Plasmodium apicoplast protein
Authors: Narayan Aishwarya , Mastud Pragati , Thakur Vandana , Rathod Pradipsinh K. , Mohmmed Asif , Patankar Swati 
Published: September 2018

Glutathione peroxidase‐like thioredoxin peroxidase (PfTPxGl) is an antioxidant enzyme trafficked to the apicoplast, a secondary endosymbiotic organelle, in Plasmodium falciparum. Apicoplast trafficking signals usually consist of N‐terminal signal and transit peptides, but the trafficking signal of PfTPxGl appears to exhibit important differences. As transfection is a protracted process in P. falciparum, we expressed the N terminus of PfTPxGl as a GFP fusion protein in a related apicomplexan, Toxoplasma gondii, in order to dissect its trafficking signals. We show that PfTPxGl possesses an N‐terminal signal anchor that takes the protein to the endoplasmic reticulum in Toxoplasma—this is the first step in the apicoplast targeting pathway. We dissected the residues important for endomembrane system uptake, membrane anchorage, orientation, spacing, and cleavage. Protease protection assays and fluorescence complementation revealed that the C terminus of the protein lies in the ER lumen, a topology that is proposed to be retained in the apicoplast. Additionally, we examined one mutant, responsible for altered PfTPxGl targeting in Toxoplasma, in Plasmodium. This study has demonstrated that PfTPxGl belongs to an emergent class of proteins that possess signal anchors, unlike the canonical bipartite targeting signals employed for the trafficking of luminal apicoplast proteins. This work adds to the mounting evidence that the signals involved in the targeting of apicoplast membrane proteins may not be as straightforward as those of luminal proteins, and also highlights the usefulness of T. gondii as a heterologous system in certain aspects of this study, such as reducing screening time and facilitating the verification of membrane topology.
Both fluid intelligence and visual object recognition ability relate to nodule detection in chest radiographs
Authors: Sunday Mackenzie A. , Donnelly Edwin , Gauthier Isabel 
Published: September 2018

SummaryRecent work suggests that some aspects of lung nodule detection ability may relate to object recognition ability. However, this work only sampled radiological novices. Here, we further investigate whether object recognition ability predicts lung nodule detection ability (as measured by the Vanderbilt Chest Radiograph Test or VCRT), after controlling for experience and fluid intelligence, in a sample of radiologists and nonradiologists. We find that radiological experience accounts for approximately 50% of VCRT variance. After controlling for experience, fluid intelligence and object recognition ability account for an additional 15% of VCRT variance. These results suggest that while training is key in learning to detect nodules, given the same experience level, those with higher fluid intelligence and object recognition ability perform better. The recently proposed construct of visual object recognition ability may add unique information relative to general cognitive skills in assessing aptitude for a career in radiology.
Left Ventricular Systolic Myocardial Function in Ankylosing Spondylitis
Authors: Midtbø Helga , Semb Anne G. , Matre Knut , Rollefstad Silvia , Berg Inger J. , Gerdts Eva 
Published: September 2018

ObjectiveSubclinical left ventricular (LV) myocardial dysfunction is associated with an increased risk of cardiovascular disease (CVD), but it is not known whether subclinical LV myocardial dysfunction is present in patients with ankylosing spondylitis (AS) independent of CVD risk factors.MethodsConventional and speckle tracking echocardiography were performed in 106 patients with AS (mean ± SD age 48 ± 12 years; 59% men) and 106 matched controls (mean ± SD age 51 ± 12 years; 59% men). LV systolic myocardial function was assessed by peak systolic global longitudinal strain (GLS).ResultsCVD risk factors were similarly distributed in patients with AS and controls, but more controls received statin therapy (P = 0.05). GLS was significantly lower in patients with AS compared to controls (mean ± SD −17.7 ± 2.5% versus −18.4 ± 2.3%; P = 0.03). In univariable linear regression analyses in the total study population, lower GLS was associated with having AS, male sex, higher body mass index, higher LV mass index, and lower LV ejection fraction (all P < 0.05). Having AS retained an independent association with lower GLS when adjusted for these factors in multivariable analyses (β = 0.16, P = 0.02). In patients with AS, lower GLS was independently associated with larger aortic root diameter in multivariable analyses (β = 0.24, P = 0.02), while no association with AS disease activity, disease duration, or use of antirheumatic medication was observed.ConclusionPatients with AS had lower GLS compared with controls, independent of confounders. In AS patients, lower GLS was associated with larger aortic root diameter. Prospective studies should test whether lower GLS contributes to the observed higher CVD risk in patients with AS.
Association of Varus Knee Thrust During Walking With Worsening Western Ontario and McMaster Universities Osteoarthritis Index Knee Pain: A Prospective Cohort Study
Authors: Wink Alexandra E. , Gross K. Douglas , Brown Carrie A. , Lewis Cora E. , Torner James , Nevitt Michael C. , Tolstykh Irina , Sharma Leena , Felson David T. 
Published: September 2018

ObjectiveTo investigate the 2‐year association of varus knee thrust observed during walking to the odds of worsening Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) knee pain in older adults with or at risk of osteoarthritis (OA).MethodsVideo recordings of self‐paced walking trials of Multicenter Osteoarthritis Study participants were assessed for the presence of varus thrust at baseline. Knee pain was assessed using the WOMAC questionnaire at baseline and at 2 years. Logistic regression was used to estimate the odds of worsening knee pain (defined as either any increase in WOMAC score or as clinically important worsening), adjusting for age, sex, race, body mass index, clinic site, gait speed, and static knee alignment. Analyses were repeated, stratified by baseline radiographic OA status and among the subset of knees without baseline WOMAC pain.ResultsA total of 1,623 participants contributed 3,204 knees. Varus thrust was observed in 31.5% of knees. Knees with varus thrust had 1.44 times (95% confidence interval [95% CI] 1.19–1.73) the odds of any worsening and 1.37 times (95% CI 1.11–1.69) the odds of clinically important worsening WOMAC pain compared to knees without thrust. Knees with thrust without baseline WOMAC pain had 2.01 times (95% CI 1.47–2.74) the odds of incident total pain.ConclusionResults indicate that varus thrust is a risk factor for worsening and incident knee pain. Targeting varus thrust through noninvasive therapies could prevent development or worsening of knee pain in older adults with or at risk for knee OA.
Do Patients With Skin Psoriasis Show Subclinical Axial Inflammation on Magnetic Resonance Imaging of the Sacroiliac Joints and Entire Spine?
Authors: Bratu Vlad A. , Häusermann Peter , Walker Ulrich A. , Daikeler Thomas , Zubler Veronika , Jaeger Veronika K. , Weber Ulrich , Studler Ueli 
Published: September 2018

ObjectiveTo explore potential subclinical involvement of the axial skeleton by magnetic resonance imaging (MRI) of the sacroiliac (SI) joints and the entire spine in patients with skin psoriasis without clinical evidence of peripheral or axial inflammation.MethodsTwenty patients with skin psoriasis but no clinical evidence of peripheral or axial inflammation and 22 healthy controls underwent standardized dermatologic and rheumatologic clinical examination and unenhanced 1.5T MRI of the SI joint and the entire spine. Two blinded readers globally assessed the presence or absence of SI joint inflammation simultaneously on T1‐weighted and short tau inversion recovery MRI sequences with a confidence estimate. Bone marrow edema, fat metaplasia, erosion, and ankylosis of the SI joint, and vertebral corner inflammatory lesions and fat lesions were recorded using standardized modules. The prevalence of each lesion type was calculated in both groups, averaged across 2 readers. The number of subjects with lesions in the SI joint and spine (≥1, 2, 3, 4, or 5 lesions) as concordantly assessed by both readers was recorded.ResultsThe median duration of skin psoriasis was 23.0 years, the median age of patients was 48.5 years, and 25.0% of patients and 9.1% of healthy controls were concordantly classified by both readers as having SI joint inflammation (P = 0.23). The prevalence of bone marrow edema and structural lesions was comparable across patients and controls, both on SI joint and spine MRI.ConclusionIn this controlled study, patients with skin psoriasis but no clinical arthritis or spondylitis showed limited evidence of concomitant subclinical axial involvement by SI joint and spine MRI. These findings do not support routine screening for subclinical axial inflammation in patients with longstanding skin psoriasis.
Peptide‐Based Multifunctional Nanomaterials for Tumor Imaging and Therapy
Authors: Zhang Chi , Wu Wei , Li Run‐Qing , Qiu Wen‐Xiu , Zhuang Ze‐Nan , Cheng Si‐Xue , Zhang Xian‐Zheng 
Published: September 2018

AbstractDuring the last decade, peptide‐based nanomaterials are recognized as upcoming biomedical materials for tumor imaging and therapy. The rapid expansion of peptides and peptide derivatives is almost owing to their excellent biocompatibility, diverse bioactivity, potential biodegradability, specific biological recognition ability, and easy chemical modification characteristic. The present review outlines the development up to now concerning the design and biomedical applications of peptide‐based multifunctional nanomaterials, with an emphasis on their variegated therapeutic methods.
Protein Nanotherapeutics as an Emerging Modality for Cancer Therapy
Authors: Cheng Liang , Yang Liang , Meng Fenghua , Zhong Zhiyuan 
Published: September 2018

AbstractProtein drugs are a unique and versatile class of biotherapeutics that have not only high biological activity but also superb specificity. This rapidly evolving biotechnology has rendered it possible to produce various proteins in a large scale and reproducible way. Many proteins have demonstrated striking anticancer activities and have emerged as advanced alternatives to cytotoxic chemotherapeutic agents for cancer therapy. The clinical translation of anticancer proteins with intracellular targets is, nevertheless, severely hindered by their fast degradation in vivo, poor cell penetration, and inefficient intracellular transportation. The past few years have witnessed tremendous effort and progress in developing polymeric protein delivery nanosystems, ranging from nanoparticles, nanocapsules, nanogels, micelles, to polymersomes, for the treatment of different tumors such as lung tumors, breast tumors, ovarian cancers, and glioblastoma. These proof‐of‐concept studies point out that protein nanotherapeutics, with rationally designed nanovehicles, are able to overcome the extracellular barriers, cell membrane barriers, and intracellular barriers, and systemically deliver proteins into targeted cancer cells, resulting in effective cancer protein therapy. Protein nanotherapeutics appear to be a novel modality for safe and efficient cancer treatment.
Biomineralization‐Inspired Material Design for Bone Regeneration
Authors: de Melo Pereira Daniel , Habibovic Pamela 
Published: September 2018

AbstractSynthetic substitutes of bone grafts, such as calcium phosphate–based ceramics, have shown some good clinical successes in the regeneration of large bone defects and are currently extensively used. In the past decade, the field of biomineralization has delivered important new fundamental knowledge and techniques to better understand this fascinating phenomenon. This knowledge is also applied in the field of biomaterials, with the aim of bringing the composition and structure, and hence the performance, of synthetic bone graft substitutes even closer to those of the extracellular matrix of bone. The purpose of this progress report is to critically review advances in mimicking the extracellular matrix of bone as a strategy for development of new materials for bone regeneration. Lab‐made biomimicking or bioinspired materials are discussed against the background of the natural extracellular matrix, starting from basic organic and inorganic components, and progressing into the building block of bone, the mineralized collagen fibril, and finally larger, 2D and 3D constructs. Moreover, bioactivity studies on state‐of‐the‐art biomimicking materials are discussed. By addressing these different topics, an overview is given of how far the field has advanced toward a true bone‐mimicking material, and some suggestions are offered for bridging current knowledge and technical gaps.
Fully Inkjet‐Printed VO2‐Based Radio‐Frequency Switches for Flexible Reconfigurable Components
Authors: Yang Shuai , Vaseem Mohammad , Shamim Atif 
Published: September 2018

AbstractFrequency‐reconfigurable radio‐frequency (RF) components are in high demand due to multiple frequency bands in wireless devices as well as varying frequency‐spectrum standards across the world. An important part of reconfigurable components is a switch; however, existing switches are very expensive, particularly for higher frequencies (≈10s of dollars). In this regard, metal–insulator transition (MIT) materials are attractive, as they can change their phase and can be used as switches. Vanadium dioxide (VO2) is one such material that features a transition temperature of only 68 °C. The cost of the switch can be brought down considerably (≈cents) if MIT materials such as VO2 can be inkjet‐printed; however, no ink of this sort is commercially available. In this work, VO2 ink and fully printed RF switches (shunt and series configurations) through this ink are presented for the first time. Both thermal and electrical triggering mechanisms are investigated in this work. These switches have shown decent performance up to 40 GHz. A more than 102 ON/OFF ratio and a switching speed of 0.4 µs are achieved. Finally, a frequency‐reconfigurable antenna, printed on a flexible Kapton substrate along with a printed VO2 switch, is demonstrated as a proof of concept.