bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of pyridyl thiosemicarbazones as highly potent agents for the treatment of malaria after oral administration
Authors: Parkinson Christopher J , Birrell Geoffrey W , Chavchich Marina , Mackenzie Donna , Haynes Richard K , de Kock Carmen , Richardson Des R , Edstein Michael D 
Published: June 2019

AbstractObjectivesDrug resistance exists to all current and investigational antimalarial drug classes. Consequently, we have set out to develop chemically and mechanistically discrete antimalarials. Here we report on the development of thiosemicarbazone (TSC) antimalarials, with TSC3 as the most advanced lead.MethodsThiosemicarbazones were generated through simple condensation reactions of thiosemicarbazides and ketones. TSC3 was selected and tested for in vitro antimalarial activities against MDR Plasmodium falciparum lines using the [3H]hypoxanthine growth assay, in vitro cytotoxicity against mammalian cell lines using the alamarBlue fluorescence cell viability assay, in vivo potency in the mouse–Plasmodium berghei model and blood exposure in mice measured by LC-MS for pharmacokinetic analysis.ResultsTSC3 showed potent in vitro activity against atovaquone-, dihydroartemisinin-, chloroquine- and mefloquine-resistant P. falciparum lines (EC50 <15 nM). The selectivity index (EC50 cells/EC50Pf W2 line) of TSC3 was >500 in two of three mammalian cell lines. In P. berghei-infected mice, TSC3 showed potent activity in the Peters 4 day suppression test (ED50 1.2 mg/kg/day) and was as potent as artesunate and chloroquine in the curative modified Thompson test. A single oral dose of TSC3 at 16 mg/kg in healthy mice achieved a mean maximum blood concentration of 1883 ng/mL at 1 h after dosing and an elimination half-life of 48.7 h in groups of five mice.ConclusionsTSC3 shows promise as a persistent, potent and orally effective antimalarial. This, coupled with the extremely low cost of synthesis, suggests that the further development of antimalarial thiosemicarbazones is clearly warranted.
I Am, Therefore I Buy: Low Self-Esteem and the Pursuit of Self-Verifying Consumption
Authors: Stuppy Anika , Mead Nicole L , Van Osselaer Stijn M J 
Published: June 2019

Abstract
The idea that consumers use products to feel good about themselves is a basic tenet of marketing. Yet, in addition to the motive to self-enhance, consumers also strive to confirm their self-views (i.e., self-verification). Although self-verification provides self-related benefits, its role in consumer behavior is poorly understood. To redress that gap, we examine a dispositional variable—trait self-esteem—that predicts whether consumers self-verify in the marketplace. We propose that low (vs. high) self-esteem consumers gravitate toward inferior products because those products confirm their pessimistic self-views. Five studies supported our theorizing: low (vs. high) self-esteem participants gravitated toward inferior products (study 1) because of the motivation to self-verify (study 2). Low self-esteem consumers preferred inferior products only when those products signaled pessimistic (vs. positive) self-views and could therefore be self-verifying (study 3). Even more telling, low self-esteem consumers’ propensity to choose inferior products disappeared after they were induced to view themselves as consumers of superior products (study 4), but remained in the wake of negative feedback (study 5). Our investigation thus highlights self-esteem as a boundary condition for compensatory consumption. By pinpointing factors that predict when self-verification guides consumer behavior, this work enriches the field’s understanding of how products serve self-motives.
Anatomical variants of the rectus femoris motor innervation
Authors: Plante Dominic , Janelle Nicolas , Angers-Goulet Mathieu , Corbeil Philippe , Takech Mohamad Ali , Belzile Etienne L 
Published: June 2019

AbstractAdult periacetabular osteotomy (PAO) was originally performed through the classic Smith-Petersen approach for optimal operative visibility and acetabular fragment correction. Evolution towards an abductor-sparing technique significantly lowered the post-operative morbidity. The rectus-sparing approach represents a step further, but the innervation of the rectus femoris is theoretically more at risk. Although the topographic anatomy of the femoral nerve has been well described, it was never studied with specificity to surgical landmarks. The femoral nerve’s spatial relation with the anterior-inferior iliac spine (AIIS) and the amount of possible dissection in the rectus femoris and iliopsoas interval is uncertain. Seven formalin-preserved human cadaveric specimens without history of inguinal injury or surgery were dissected using the distal limb of an iliofemoral approach. The level of entry of motor innervation was measured and number of branches to the rectus femoris was noted. The average longitudinal distance from the AIIS to the first motor nerve to the rectus femoris was 8.6 ± 1.4 cm. The number of branches varied between 1 and 4 with the most common innervation pattern being composed of two segments. Dissection medial to the rectus femoris should not be carried out further than 7 cm distal to the AIIS and stretching of that interval during surgical exposure should be done cautiously. The clinical efficiency of the rectus-sparing approach should be studied further in order to confirm its advantage over the classic direct anterior approach. The study provides a better understanding of the localization and the anatomical variations of the structures encountered at the level of and below the AIIS. It also assesses the relative risk of denervation of the rectus femoris during PAO through the rectus-sparing approach. The authors recommend that the dissection medial to the rectus femoris should be carried out no further than 7 cm distal to the AIIS and stretching of that interval during surgical exposure should be done cautiously.
First Determination of Pyrethroid Knockdown Resistance Alleles in Human Head Lice (Phthiraptera: Pediculidae) From Chile
Authors: Roca-Acevedo Gonzalo , del Solar Kupfer Carmen Paz , Dressel Roa Paulina , Toloza Ariel Ceferino 
Published: June 2019

AbstractThe infestation with the human ectoparasite, Pediculus humanus capitis (De Geer), is a common public health problem affecting schoolchildren worldwide. In Chile, the main active ingredients present in the over-the-counter pediculicides contain pyrethroids. Despite the extended use of these products, there is no evidence of the insecticide resistance status of the head lice geographically located in Chile. The most extended resistant mechanism of pyrethroids consists of the target site insensitivity (Kdr) determined by the presence of mutations linked to insecticide-binding sites in the voltage-sensitive sodium channel. T917I is recognized as the main mutation in head lice, and detection is considered to be a biomarker of resistance. The goal of the present study was to detect the presence and distribution of T917I mutation in five geographic locations of Chile. All five geographically selected louse populations had a frequency of pyrethroid resistance genes that ranged from 36 to 77%, and 94.9% of the collected head lice had one or two T917I mutant alleles. Moreover, the frequency of the aggregate resistant alleles was 50.5%. This is the first evidence that head lice in Chile had the mutations commonly associated with the resistance to pyrethroids. Moreover, the overrepresentation of heterozygotes in the studied populations suggests that head lice in Chile are currently under active selective pressure.
The role of biochars in sustainable crop production and soil resiliency
Authors: Jiang Zhixiang , Lian Fei , Wang Zhenyu , Xing Baoshan 
Published: June 2019

AbstractBiochar is a promising soil additive for use in support of sustainable crop production. However, the high level of heterogeneity in biochar properties and the variations in soil composition present significant challenges to the successful uptake of biochar technologies in diverse agricultural soils. An improved understanding of the mechanisms that contribute to biochar–soil interactions is required to address issues related to climate change and cultivation practices. This review summarizes biochar modification approaches (physical, chemical, and biochar-based organic composites) and discusses the potential role of biochar in sustainable crop production and soil resiliency, including the degradation of soil organic matter, the improvement of soil quality, and reductions in greenhouse gas emissions. Biochar design is crucial to successful soil remediation, particularly with regard to issues arising from soil structure and composition related to crop production. Given the wide variety of feedstocks for biochar production and the resultant high surface heterogeneity, greater efforts are required to optimize biochar surface functionality and porosity through appropriate modifications. The design and establishment of these approaches and methods are essential for the future utilization of biochar as an effective soil additive to promote sustainable crop production.
The origin of stellar populations in the Galactic bulge from chemical abundances
Authors: Matteucci F , Grisoni V , Spitoni E , Zulianello A , Rojas-Arriagada A , Schultheis M , Ryde N 
Published: June 2019

ABSTRACT
In this work, we study the formation and chemical evolution of the Galactic bulge with particular focus on the abundance pattern ([Mg/Fe] versus [Fe/H]), metallicity, and age distribution functions. We consider detailed chemical evolution models for the Galactic bulge and inner disc, with the aim of shedding light on the connection between these components and the origin of bulge stars. In particular, we first present a model assuming a fast and intense star formation, with the majority of bulge stars forming on a time-scale less than 1 Gyr. Then we analyse the possibility of two distinct stellar populations in the bulge, as suggested by Gaia-ESO and APOGEE data. These two populations, one metal poor and the other metal rich, can have had two different origins: (i) the metal rich formed after a stop of ∼250 Myr in the star formation rate of the bulge or (ii) the metal-rich population is made of stars formed in the inner disc and brought into the bulge by the early secular evolution of the bar. We also examine the case of multiple starbursts in the bulge with consequent formation of multiple populations, as suggested by studies of microlensed stars. After comparing model results and observations, we suggest that the most likely scenario is that there are two main stellar populations, both made mainly by old stars (>10 Gyr), with the metal-rich and younger one formed from inner thin disc stars, in agreement with kinematical arguments. However, on the basis of dynamical simulations, we cannot completely exclude that the second population formed after a stop in the star formation during the bulge evolution, so that all the stars formed in situ.
Non-thermal emission and spectral evolution properties of G54.1+0.3
Authors: Ren Ji-Yang , Gao Quan-Gui , Li Huai-Zhen , Ma Ju , Zhao Shan-Shan , Liu Ya-li , Lu Fang-Wu 
Published: June 2019

ABSTRACT
The multiband photon emission and spectral evolution of G54.1+0.3 are investigated in the framework of leptonic and leptonic–hadronic models. We model the spectral energy distribution (SED) of the pulsar wind nebula (PWN) and find that both the leptonic and leptonic–hadronic models can well reproduce the multiband observations of the nebula with appropriate model parameters. Combining with dynamical evolution of the PWN, we investigate the time evolution of photon SED and radiative luminosity in the X-ray and TeV γ-ray bands of G54.1+0.3. The results indicate that the synchrotron spectrum and radiative luminosity in the X-ray band of the PWN calculated with these two models have obvious differences as the age increases to about 4 kyr, and the largest difference is present at about 40 kyr. The γ-ray luminosity calculated by the leptonic–hadronic model shows that the contribution of TeV photons arising from the decay of neutral pions produced in proton–proton interaction also changes with time and is always important for modifying the TeV γ-ray spectrum of G54.1+0.3 during the evolution of the PWN.
Cosmic distance determination from photometric redshift samples using BAO peaks only
Authors: Sridhar Srivatsan , Song Yong-Seon 
Published: June 2019

ABSTRACT
The galaxy distributions along the line of sight are significantly contaminated by the uncertainty on redshift measurements obtained through multiband photometry, which makes it difficult to get cosmic distance information measured from baryon acoustic oscillations, or growth functions probed by redshift distortions. We investigate the propagation of the uncertainties into large-scale clustering by exploiting all known estimators, and propose the wedge approach as a promising analysis tool to extract cosmic distance information still remaining in the photometric galaxy samples. We test our method using simulated galaxy maps with photometric uncertainties of σ0 = (0.01, 0.02, 0.03). The measured anisotropy correlation function ξ is binned into the radial direction of s and the angular direction of μ, and the variations of $\xi (s,\mu)\,$with perpendicular and radial cosmic distance measures of DA and H−1 are theoretically estimated by an improved RSD model. Although the radial cosmic distance H−1 is unable to be probed from any of the three photometric galaxy samples, the perpendicular component of DA is verified to be accurately measured even after the full marginalization of H−1. We measure DA with approximately 6 per cent precision which is nearly equivalent to what we can expect from spectroscopic DR12 CMASS galaxy samples.
Survivability of radio-loud planetary cores orbiting white dwarfs
Authors: Veras Dimitri , Wolszczan Alexander 
Published: June 2019

ABSTRACT
The discovery of the intact metallic planetary core fragment orbiting the white dwarf SDSS J1228+1040 within one Solar radius highlights the possibility of detecting larger, unfragmented conducting cores around magnetic white dwarfs through radio emission. Previous models of this decades-old idea focused on determining survivability of the cores based on their inward Lorentz drift towards the star. However, gravitational tides may represent an equal or dominant force. Here, we couple both effects by assuming a Maxwell rheological model and performing simulations over the entire range of observable white dwarf magnetic field strengths (103–109 G) and their potential atmospheric electrical conductivities (10−1–104 S m−1) in order to more accurately constrain survivability lifetimes. This force coupling allows us to better pinpoint the physical and orbital parameters which allow planetary cores to survive for over a Gyr, maximizing the possibility that they can be detected. The most robust survivors showcase high dynamic viscosities (≳1024 Pa s) and orbit within kG-level magnetic fields.
Massive binary star mergers in galactic nuclei: implications for blue stragglers, binary S-stars, and gravitational waves
Authors: Fragione Giacomo , Antonini Fabio 
Published: June 2019

ABSTRACT
Galactic nuclei are often found to contain young stellar populations and, in most cases, a central supermassive black hole (SMBH). Most known massive stars are found in binaries or higher multiplicity systems, and in a galactic nucleus the gravitational interaction with the SMBH can affect their long-term evolution. In this paper, we study the orbital evolution of stellar binaries near SMBHs using high precision N-body simulations, and including tidal forces and post-Newtonian corrections to the motion. We focus on the Lidov–Kozai (LK) effect induced by the SMBH on massive star binaries. We investigate how the properties of the merging binaries change with varying the SMBH mass, the slope of the initial mass function, the distributions of the binary orbital parameters, and the efficiency in energy dissipation in dissipative tides. We find that the fraction of merging massive binary stars is in the range ∼4–$15{{\ \rm per\ cent}}$ regardless of the details of the initial distributions of masses and orbital elements. For a Milky Way-like nucleus, we find a typical rate of binary mergers $\Gamma \approx 1.4\times 10^{-7} {\, \rm yr}^{-1}$. The merger products of massive binaries can be rejuvenated blue-straggler stars, more massive than each of their original progenitors, and G2-like objects. Binary systems that survive the LK cycles can be source of X-rays and gravitational waves, observable with present and upcoming instruments.
Powerful AGN jets and unbalanced cooling in the hot atmosphere of IC 4296
Authors: Grossová R , Werner N , Rajpurohit K , Mernier F , Lakhchaura K , Gabányi K , Canning R E A , Nulsen P , Massaro F , Sun M , Connor T , King A , Allen S W , Frisbie R L S , Donahue M , Fabian A C 
Published: June 2019

Abstract
We present new Karl G. Jansky Very Large Array (VLA, 1.5 GHz) radio data for the giant elliptical galaxy IC 4296, supported by archival radio, X-ray (Chandra, and XMM–Newton) and optical (SOAR, and HST) observations. The galaxy hosts powerful radio jets piercing through the inner hot X-ray emitting atmosphere, depositing most of the energy into the ambient intracluster medium (ICM). Whereas the radio surface brightness of the A configuration image is consistent with a Fanaroff–Riley Class I system, the D configuration image shows two bright, relative to the central region, large (${\sim } 160\, \rm {kpc}$ diameter), well-defined lobes, previously reported by Killeen et al., at a projected distance $r\gtrsim 230\, \rm {kpc}$. The XMM–Newton image reveals an X-ray cavity associated with one of the radio lobes. The total enthalpy of the radio lobes is ${\sim }7\times 10^{59}\, \rm {erg}$ and the mechanical power output of the jets is ${\sim } 10^{44}\, \rm {erg\, s}^{-1}$. The jets are mildly curved and possibly rebrightened by the relative motion of the galaxy and the ICM. The lobes display sharp edges, suggesting the presence of bow shocks, which would indicate that they are expanding supersonically. The central entropy and cooling time of the X-ray gas are unusually low and the nucleus hosts a warm Hα + [$\rm{N\,{\small II}}$] nebula and a cold molecular CO disc. Because most of the energy of the jets is deposited far from the nucleus, the atmosphere of the galaxy continues to cool, apparently feeding the central supermassive black hole and powering the jet activity.
Quantum Bayesianism Assessed
Authors: Earman John 
Published: June 2019

Abstract
The idea that the quantum probabilities are best construed as the personal/subjective degrees of belief of Bayesian agents is an old one. In recent years the idea has been vigorously pursued by a group of physicists who fly the banner of quantum Bayesianism (QBism). The present paper aims to identify the prospects and problems of implementing QBism, and it critically assesses the claim that QBism provides a resolution (or dissolution) of some of the long-standing foundations issues in quantum mechanics, including the measurement problem and puzzles of nonlocality.
Identification of DNA motifs that regulate DNA methylation
Authors: Wang Mengchi , Zhang Kai , Ngo Vu , Liu Chengyu , Fan Shicai , Whitaker John W , Chen Yue , Ai Rizi , Chen Zhao , Wang Jun , Zheng Lina , Wang Wei 
Published: June 2019

AbstractDNA methylation is an important epigenetic mark but how its locus-specificity is decided in relation to DNA sequence is not fully understood. Here, we have analyzed 34 diverse whole-genome bisulfite sequencing datasets in human and identified 313 motifs, including 92 and 221 associated with methylation (methylation motifs, MMs) and unmethylation (unmethylation motifs, UMs), respectively. The functionality of these motifs is supported by multiple lines of evidence. First, the methylation levels at the MM and UM motifs are respectively higher and lower than the genomic background. Second, these motifs are enriched at the binding sites of methylation modifying enzymes including DNMT3A and TET1, indicating their possible roles of recruiting these enzymes. Third, these motifs significantly overlap with “somatic QTLs” (quantitative trait loci) of methylation and expression. Fourth, disruption of these motifs by mutation is associated with significantly altered methylation level of the CpGs in the neighbor regions. Furthermore, these motifs together with somatic mutations are predictive of cancer subtypes and patient survival. We revealed some of these motifs were also associated with histone modifications, suggesting a possible interplay between the two types of epigenetic modifications. We also found some motifs form feed forward loops to contribute to DNA methylation dynamics.
High-throughput amplicon sequencing of the full-length 16S rRNA gene with single-nucleotide resolution
Authors: Callahan Benjamin J , Wong Joan , Heiner Cheryl , Oh Steve , Theriot Casey M , Gulati Ajay S , McGill Sarah K , Dougherty Michael K 
Published: June 2019

AbstractTargeted PCR amplification and high-throughput sequencing (amplicon sequencing) of 16S rRNA gene fragments is widely used to profile microbial communities. New long-read sequencing technologies can sequence the entire 16S rRNA gene, but higher error rates have limited their attractiveness when accuracy is important. Here we present a high-throughput amplicon sequencing methodology based on PacBio circular consensus sequencing and the DADA2 sample inference method that measures the full-length 16S rRNA gene with single-nucleotide resolution and a near-zero error rate. In two artificial communities of known composition, our method recovered the full complement of full-length 16S sequence variants from expected community members without residual errors. The measured abundances of intra-genomic sequence variants were in the integral ratios expected from the genuine allelic variants within a genome. The full-length 16S gene sequences recovered by our approach allowed Escherichia coli strains to be correctly classified to the O157:H7 and K12 sub-species clades. In human fecal samples, our method showed strong technical replication and was able to recover the full complement of 16S rRNA alleles in several E. coli strains. There are likely many applications beyond microbial profiling for which high-throughput amplicon sequencing of complete genes with single-nucleotide resolution will be of use.
Criminally Ignorant
Authors: Sarch Alexander 
Published: June 2019

Abstract
Criminally Ignorant: Why the Law Pretends We Know What We Don’t is about the legal fiction that we know what we don’t. If you bury your head in the sand rather than learn you’re committing a crime, you can be punished as if you knew. How can that be justified? This book offers a framework to explain why it’s not as puzzling as it seems. When remaining ignorant of the facts is sufficiently culpable, the interests and values protected by the criminal law are served by punishing you as though you knew those facts. This idea—imputing mental states based on equal culpability—is what this book seeks to justify (at least within limits). The resulting theory shows that some legal fictions—like the willful ignorance doctrine—require reform. At the same time, it shows why we also need more legal fictions of this kind. Moreover, they should be extended to impose further accountability on corporations. Still, equal culpability imputation can be taken too far. We need to determine its limits to avoid injustice. Thus, the book seeks to place equal culpability imputation on a solid normative foundation, while demarcating its proper boundaries. The resulting theory of when and why the criminal law can pretend we know what we don’t has far-reaching implications for legal practice and reveals the pressing need for reform.