bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age
Authors: Diena Davide , Messina Maria , De Biase Consuelo , Fop Fabrizio , Scardino Edoardo , Rossetti Maura Maria , Barreca Antonella , Verri Aldo , Biancone Luigi 
Published: August 2019

Abstract
Background

Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored.

Methods

This study investigated the impact of post transplant proteinuria in the first year in 1127 kidney transplants analyzing the impact of different donor ages. Proteinuria cut off was set at 0.5 g/day.

Results

Transplants with proteinuria > 0.5 g/day correlated with poor graft and patient outcome in all donor age groups. In addition, 6-month-1-year proteinuria increase was significantly associated with graft outcome, especially with donors > 60 years old (p < 0.05; Odd Ratio 1.8). 1-year graft function (eGFR < or ≥44 ml/min) had similar impact to proteinuria (≥ 0.5 g/day) on graft failure (HR 2.77 vs HR 2.46). Low-grade proteinuria (0.2-0.5 g/day) demonstrated a trend for worse graft survival with increasing donor age. Also in kidney-paired analysis proteinuria ≥ 0.5 effect was more significant with donors >50 years old (OR 2.3).

Conclusions

Post-transplant proteinuria was increasingly harmful with older donor age. Proteinuria ≥ 0.5 g/day correlates with worse outcomes in all transplanted patients. Prognostic value of proteinuria and eGFR for graft and patient survival was comparable and these two variables remain significant risk factors even in a multivariate model that take into consideration the most important clinical variables (donor age, rejection, delayed graft function and cytomegalovirus viremia among others).
Constraining the timing and character of crustal melting in the Adirondack Mountains using multi-scale compositional mapping and in-situ monazite geochronology
Authors: Williams Michael L. , Grover Timothy , Jercinovic Michael J. , Regan Sean P. , Pless Claire R. , Suarez Kaitlyn A. 
Published: August 2019

AbstractMigmatites are common in the hinterland of orogenic belts. The timing and mechanism (in situ vs. external, P-T conditions, reactions, etc.) of melting are important for understanding crustal rheology, tectonic history, and orogenic processes. The Adirondack Highlands has been used as an analog for mid/deep crustal continental collisional tectonism. Migmatites are abundant, and previous workers have interpreted melting during several different events, but questions remain about the timing, tectonic setting, and even the number of melting events. We use multiscale compositional mapping combined with in situ geochronology and geochemistry of monazite to constrain the nature, timing, and character of melting reaction(s) in one locality from the eastern Adirondack Highlands. Three gray migmatitic gneisses, studied here, come from close proximity and are very similar in microscopic and macroscopic (outcrop) appearance. Each of the rocks is interpreted to have undergone biotite dehydration melting (i.e., Bt + Pl + Als + Qz = Grt + Kfs + melt). Full-section compositional maps show the location of reactants and products of the melting reaction, especially prograde and retrograde biotite, peritectic K-feldspar, and leucosome, in addition to all monazite and zircon in context. In addition, the maps provide constraints on kinematics during melting and a context for interpretation of accessory phase composition and geochronology. More so than zircon, monazite serves as a monitor of melting and melt loss. The growth of garnet during melting leaves monazite depleted in Y and HREEs while melt loss from the system leaves monazite depleted in U. Results show that in all three localities, partial melting occurred during at ca. 1160–1150 Ma (Shawinigan orogeny), but the samples show high variability in the location and degree of removal of the melt phase, from near complete to segregated into layers to dispersed. All three localities experienced a second high-T event at ca. 1050 Ma, but only the third (non-segregated) sample experienced further melting. Thus, in addition to bulk composition, the fertility for melting is an important function of the previous history and the degree of mobility of earlier melt and fluids. Monazite is also a sensitive monitor of retrogression; garnet breakdown leads to increased Y and HREE in monazite. Results here suggest that all three samples remained at depth between the two melting events but were rapidly exhumed after the second event.
Synthesis and Cytotoxicity of New Mannich Bases of 6-[3-(3,4,5-Trimetoxyphenyl)-2- propenoyl]-2(3H)-Benzoxazolone
Authors: Petrov Ognyan Ivanov , Ivanova Yordanka Borisova , Gerova Mariana Stefanova , Momekov Georgi Tsvetanov 
Published: August 2019

Background:
Chemotherapy is one of the mainstays of cancer treatment, despite the serious
side effects of the clinically available anticancer drugs. In recent years increasing attention has
been directed towards novel agents with improved efficacy and selectivity. Compounds with chalcone
backbone have been reported to possess various biological activities such as anticancer, antimicrobial,
anti-inflammatory, analgesic, antioxidant, etc. It was reported that aminomethylation of
hydroxy chalcones to the corresponding Mannich bases increased their cytotoxicity. In this context,
our interest has been focused on the design and synthesis of the so-called multi-target molecules,
containing two or more pharmacophore fragments.

Methods:
A series of Mannich bases were synthesized by the reaction between 6-[3-(3,4,5-
trimethoxyphenyl)-2-propenoyl]-2(3Н)-benzoxazolone, formaldehyde, and a secondary amine. The
structures of the compounds were confirmed by elemental analysis, IR and NMR spectra. The new
Mannich bases were evaluated for their in vitro cytotoxicity against a panel of human tumor cell
lines, including BV-173, SKW-3, K-562, HL-60, HD-MY-Z and MDA-MB-231. The effects of selected
compounds on the cellular levels of glutathione (GSH) were determined.

Results:
The new compounds 4a-e exhibited concentration-dependent cytotoxic effects at micromolar
concentrations in MTT-dye reduction assay against a panel of human tumor cell lines, similar to those of
starting chalcone 3. The tested agents led to concentration - dependent depletion of cellular GSH levels,
whereby the effects of the chalcone prototype 3 and its Mannich base-derivatives were comparable.

Conclusion:
The highest chemosensitivity to the tested compounds was observed in BV-
173followed by SKW-3 and HL-60 cell lines.
Receptor Binding Inhibitor Suppresses Carcinogenesis of Cervical Cancer by Depressing Levels of FSHR and ERβ in Mice
Authors: Gong Zhuandi , Shen Xiaoyun , Yang Juan , Lai Luju , Wei Suocheng 
Published: August 2019

Background:
FSH Receptor Binding Inhibitor (FRBI) blocked the binding of FSH to FSHR. Our
initial study revealed FRBI reduced the maturation rate, enhanced the apoptosis of sheep Cumulus-Oocyte
Complex (COCs). Little is known about whether FRBI modulates ERβ and FSHR levels in the normal uterine
and cancerous tissues. The present study aimed to evaluate the FRBI effects on the expressions of Estrogen
Receptor-beta (ERβ) and FSH receptor (FSHR) in the uteri.

Methods:
Methods: 150 mice were assigned to FRBI+FSH (COM), FSH and control groups (CG). Mice of COM-1,
COM-2 and COM-3 groups were simultaneously intramuscularly injected with 500, 750 and 1000 µg FRBI with
10 IU FSH, respectively for five days. Western blotting and qPCR were utilized to determine the expression of
ERβ and FSHR.

Results:
In comparison with FSH group, uterine lumen and glands of COM groups became narrow. The uterine
wall and endometrial epithelium were thinned, and uterine lumen became narrow. Epithelial cells were decreased.
Uterine wall thicknesses of COM-1, COM-2 and COM-3 groups were reduced by 6.49%, 14.89% and
15.69% on day 30 as compared with FSH group. Uterine perimetrium thicknesses of COM-1, COM-2 and
COM-3 groups were reduced by 16.17%, 17.93% and 19.92% on day 20 in comparison with FSH group. Levels
of FSHR mRNAs and proteins of COM-1, COM-2 and COM-3 groups were less than FSH group on days 20
and 30 (P<0.05). ERβ protein of COM-3 group was less than FSH group. Serum estradiol (E2) and FSH concentrations
of COM-2 and COM-3 were lower than that of FSH group on day 30.

Conclusion:
FRBI could decrease UWT and UPT, also block the uterine development, decline expression levels
of ERβ and FSHR protein. Additionally, FRBI reduced the secretion of secretion of FSH and E2. Downregulating
expression of FSHR and ERβ may be a potential treatment regimen for cervical cancer patients.
Investigation on the Polymer Drawing Model of the Centrifugal Spinning
Authors: Liu Jia-Jia , Wu Li-Li , Chen Ting 
Published: August 2019

Background and Objective:
Some patents have reported the centrifugal spinning method
which utilizes the centrifugal force produced by a high speed rotating device to fabricate fibers from
polymer melts or solutions. Recently, with the development of technologies, centrifugal spinning was
employed to produce ultrafine fibers and nanofibers. In order to improve the equipment and technology
of centrifugal spinning and obtain finer fibers, it is important to model the polymer drawing of the
centrifugal spinning.

Methods:
The polymer drawing in the centrifugal spinning is modeled and simulated. The force balance
equation and heat transfer balance equation are established after analyzing the motion and heat
transfer of the polymer melts. These nonlinear equations are solved based on the least square method
to obtain the radius of excircle and the shape of streamline. A fourth order Runge-Kutta method is utilized
to obtain the diameter and temperature of the threadline because there are initial value problems
of first order ordinary differential equations. Streamlines and diameter of polymer melts at different
viscoelasticities and different spinning temperatures are obtained. The simulation results are compared
with the measured results to verify the polymer drawing model.

Results:
The viscoelastic force in the centrifugal spinning changes constantly at a fixed rotation speed
of the rotating spinneret. As the spinneret is rotating, the radius of excircle R1 increases slowly when
the time passes, which means the viscoelastic force decreases slowly. The change of the viscoelastic
force accelerates the increase of the radius vector. The simulation results show that the threadline diameter
under the condition of changing viscoelastic forces is smaller than that under the condition of
fixed visoelastic forces. The temperature of the polymer melts decreases faster under the condition of
changing viscoelastic forces than that under the condition of fixed visoelastic forces. The threadline diameter
decreases with the increase of the rotation speed. Higher initial polymer temperatures yield
smaller fiber diameters.

Conclusion:
The polymer drawing in the centrifugal spinning is modeled and simulated. The simulation
results tally with the measured results confirming the effectiveness of the polymer drawing model.
The simulation results show that the change of the viscoelastic force is favorable to the polymer drawing
and both larger rotation speeds and higher initial polymer temperatures can produce finer fibers,
which lays a good foundation for the computer-assisted design of the centrifugal spinning.
The Debt-Equity Choice When Regulatory Thresholds are Based on Equity Values: Evidence from SOX 404
Authors: Weber David P. , Yang Yanhua Sunny 
Published: August 2019

ABSTRACT
When larger market values of equity result in being subject to costly regulation, firms have incentives to shift their sources of financing toward debt and away from equity. We use the Sarbanes-Oxley Act of 2002 (SOX) as a setting to provide evidence of such incentives. Smaller firms were granted several reprieves and eventually exempted from the internal control audit requirements of SOX Section 404, which many consider the most costly and onerous aspect of SOX. Using a difference-in-differences design, we show that relative to control firms, firms just below the regulatory threshold have increased propensities to issue debt, decreased propensities to issue equity, and increased leverage levels in the post-SOX period. These results are consistent with firms altering their financing choices to maintain their exempt status and demonstrate an economic consequence of regulatory regimes that are tiered by equity values.
Relecturas posmodernas del Quijote en Breaking Bad. Cultura de masas y democratización estética en la ficción serial
Authors: Núñez Sabarís Xaquín 
Published: August 2019

Las series televisivas, de alcance global y consumo masivo, han ensanchado los límites del campo cultural actual, conformando una nueva categoría de narración audiovisual. La proyección de producciones como The Sopranos, The Wireo Lostha trascendido el marco local para convertirse en productos de referencia a nivel mundial. El universo digital ha posibilitado la rápida circulación de estas series y ha modificado la relación entre mercado, productor y consumo, motivado por la incidencia de las plataformas de Video On Demand(VOD), la generalización de los dispositivos ultraleves y la expansión de las redes sociales.
Este artículo pretende analizar cómo estas ficciones seriales han interiorizado la tradición literaria para construir un producto que transciende el entretenimiento para adentrarse en las preocupaciones sociales, filosóficas y políticas de las sociedades de hoy en día. Para ello, y con la finalidad de señalar convergencias intermediales, desde el punto de vista de la recepción deBreaking Bad, nos centraremos en el análisis de esta serie, como una relectura posmoderna del Quijote.
External Debt Financing and Public Capital Investment in Nigeria: A Critical Evaluation
Authors: Omodero Cordelia Onyinyechi 
Published: August 2019

Abstract
This study considers the consequences of external loan on capital investment in Nigeria. Data for the study have been collected from the World Bank and Central Bank of Nigeria Statistical Bulletin, 2018 edition. The variables on which data are sourced include government capital expenditure, external debt accumulation, debt servicing cost, inflation rate, and exchange rate. Government capital expenditure is the dependent variable, while external debt accumulation and debt servicing cost are the key independent variables. Inflation and exchange rates are used as the moderating variables. The scope of the study covers the period from 1996 to 2018 and the data are analysed using the ordinary least squares multiple regression method. The regression results indicate that external debt has a significant negative impact on capital investment while debt servicing cost has a strong and significant positive effect on capital investment. Under this circumstance, the controlling variables are not significant in influencing capital investment. Hence, the study suggests more focus on profitable capital investments if external borrowing must be embarked upon. The need for the development of untapped natural resources, establishment of industries and revival of abandoned industries to boost debt repayment has been emphasized. The study also strongly recommends that the existing governments (state and federal) should endeavour to complete capital projects of past administrations in order to drive the economy and to avoid wastage of financial resources including the borrowed funds.
Pengaruh Konsetrasi Carboxymethylcellulose (CMC) dan Gula Stevia terhadap Karakter Sirup Buah Tin (Ficus carica, L)
Authors: Widyastuti Retno , Afriyanti Afriyanti , Asmoro Novian Wely , Hartati Sri 
Published: August 2019

Processing figs into food and beverage products will increase the attractiveness to consume this nutrient-rich fruit. One of them is by processing it into syrup. The purpose of this study is to (1) Knowing the effect of the stevia sugar concentration on the physical and chemical characteristics of fig syrup; (2) Knowing the effect of the carboxymethylcellulose (CMC) concentration on the physical and chemical characteristics of fig syrup. The experimental design used in this study was a completely randomized design (CRD) factorial pattern with two treatment factors, namely the concentration of stevia sugar (A) with four types of treatment levels, A1 = 0% (100% sucrose); A2 = 1%; A3 = 2%; A4 = 3%. Concentration of CMC (B) with three types of treatment, B1 = CMC 0%; B2 = CMC 0.25%; B3 = CMC 0.5%. Each treatment was repeated twice to obtain 4 x 3 x 2 = 24 experimental units. The results show the brightest color produced by 100% sucrose with CMC 0% which is equal to 36.24 (L). The highest sugar content was produced in syrup with the addition of stevia 3% and CMC 0% which amounted to 34.46%. The highest viscosity is produced in syrup with the addition of 100% sucrose and CMC 0.5% which is equal to 365.2 cP.)
Correlación entre marcadores serológicos y ecográficos en pacientes con hígado graso no alcohólico y diabetes mellitus tipo 2
Authors: Quevedo Ramírez Naibel , Pérez Castillo Raydel , Sánchez Gendriz Isnielly Virgen 
Published: August 2019

Introducción: Los diabéticos tipo 2 tienen un alto riesgo de padecer hígado graso no alcohólico. La detección e intervención temprana podrían reducir el riesgo cardiovascular, prevenir sus complicaciones y reducir su progresión. El objetivo es evaluar la correlación entre los marcadores por ecografía abdominal y marcadores serológicos indirectos en pacientes diabéticos tipo 2 con hígado graso no alcohólico. Método: Se realizó un estudio descriptivo, correlacional y transversal. Se estudiaron 33 pacientes por ecografía abdominal para evaluar la severidad de la esteatosis hepática. Los marcadores serológicos indirectos fueron glicemia, colesterol total, triglicéridos, alanino-transaminasa, aspartato-transaminasa y ganmaglutamil-transferasa. Se contrastaron los resultados de ambos marcadores mediante T de Student, prueba de ajuste de Kolmogorov y análisis de varianza. Resultados: La edad promedio fue de 54,9 ± 9,1 años. Se observó con más frecuencia marcador hiperecogénico moderado (45,5 %) con patrón difuso. Los marcadores serológicos indirectos más alterados fueron glicemia (n=29; 87,8%), triglicéridos (n=25; 75,8 %), colesterol total (n=22; 66,7) y alanino-transaminasa (n= 21; 63,6 %). Los niveles de glicemia y enzima ASAT ofrecieron valores de Rho Spearman de r=0,65 y r=0,61 respectivamente. Conclusión: El desarrollo del hígado graso no alcohólico pareciera estar ligado a descompensación metabólica crónica e insulinorresistencia. Los niveles de glicemia y enzima ASAT fueron los marcadores serológicos indirectos que presentaron la mayor correlación estadística con los grados de lesión hepática diagnosticada por ecografía abdominal. Se recomienda el uso de modelos predictivos a partir de variables clínicas, marcadores serológicos indirectos y ecográficos en el diagnóstico y seguimiento a pacientes con hígado graso no alcohólico por su sencillez, y buena correlación con técnicas más complejas. La estratificación de riesgo con el empleo de dichos herramientas posibilita implementar medidas tempranas para reducir la morbimortalidad por causa cardiovascular
DIABETES MELLITUS TIPO 2: PLANTAS MEDICINAIS E FITOTERÁPICOS COMO ALTERNATIVAS TERAPÊUTICAS PARA O CONTROLE DA DOENÇA
Authors: Rigodanzo Camila , Dutra Bruna , Almeida Alves Izabel 
Published: August 2019

<p><strong>Resumo: </strong>O Diabetes <em>mellitus</em> tipo 2 (DM2) é um problema de saúde pública mundial. As complicações são graves, com comprometimeno do sistema cardiovascular, cerebral e falência de órgãos. O uso de fitoterápicos e plantas medicinais vem sendo estudados para tratamento da DM2. Essa prática possúi como vantagem ser acessível e de baixo custo, além de auxiliar na qualidade de vida dos pacientes. O objetivo deste estudo é revisar as plantas medicinais e fitoterápicos utilizados por pessoas diagnosticadas com DM2 em estudos clínicos, como terapia complementar no tratamento. Trata-se de revisão narrativa da literatura, composta por estudos publicadas no período de 1998 a 2018, incluindo artigos científicos nos idiomas Português, Inglês e Espanhol, os descritores utilizados foram: diabete <em>mellitus</em>; Diabetes <em>mellitus</em> tipo 2; extratos vegetais; plantas medicinais; fitoterápicos; complicações do Diabetes tipo 2, estudos clínicos. Desta busca foram encontrados 97 artigos que abordavam sobre diabetes, causas e consequências, destes, 45 atendiam o enfoque deste trabalho e 14 foram utilizados para discussão, sendo 9 sobre plantas medicinais e 5 sobre fitoterápicos. Os dados demonstraram que os fitoterápicos e plantas medicinais apresentaram efeitos benéficos para redução dos níveis de glicose sanguínea em pacientes com DM2, porém mais estudos devem ser realizados para comprovação da eficácia e segurança. </p>
Anais do XIX Congresso Brasileiro de Enfermagem Oncológica e XI Jornada de Enfermagem do INCA
Authors: INCA Instituto Nacional de Câncer José Alenca - 
Published: August 2019

A XI Jornada de Enfermagem em Oncologia do Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) e do XIX Congresso Brasileiro de Enfermagem Oncológica, cujo tema é: Qualidade na Dimensão do Cuidado de Enfermagem em Oncologia, foi pensada com o objetivo de promover a discussão da qualidade no cuidado, no ensino, na pesquisa e na gerência de enfermagem na área oncológica. Foram três dias de atividades e reflexões com intensa troca de experiências por meio de palestras e apresentação de trabalhos, buscando o aprimoramento da enfermagem oncológica no Brasil.
Peran Trait Mindfulness terhadap Stres Kehamilan
Authors: Chandra Alifa Rizki , Febriani Zulfa 
Published: August 2019

Pregnancy and giving birth are special moment in women’s life. Pregnancy starts with a dynamic growing period and significant development both physical and mental. Women’s judgement on her pregnancy can determine whether it can be a stressful or not. Trait mindfulness (observing, describing, acting with with awareness, non-judging, nonreactivity) could affect someone on perceiving all accepting daily experience. Trait mindfulness related to mental health. Islam also suggest people to tafakur (contemplate). The study aimed to determine how the role of trait mindfulness take part in a pregnancy stress. The sample was 223 pregnant woman and was taken by accidental sampling technique. This research use Five Facet Mindfulness Questionnaire (FFMQ) Indonesian Version and Pregnancy Experiences Scale – Brief Version (PES-Brief) Indonesian Version as measuring instrument. The result of regression test showed that trait mindfulness on the dimention of acting with awareness predicted 7.3% (R-Square value 0.073, F value 3.439, p value 0,005) the pregnancy stress. However on the dimention of observing, describing, non-judging and non-reactivitydid not has role in the pregnancy stress.