bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theta oscillations mediate pre-activation of highly expected word initial phonemes
Authors: Monsalve Irene F. , Bourguignon Mathieu , Molinaro Nicola 
Published: June 2018

AbstractPrediction has been proposed to be a fundamental neurocognitive mechanism. However, its role in language comprehension is currently under debate. In this magnetoencephalography study we aimed to find evidence of word-form phonological pre-activation and to characterize the oscillatory mechanisms supporting this. Participants were presented firstly with a picture of an object, and then, after a delay (fixed or variable), they heard the corresponding word. Target words could contain a phoneme substitution, and participants’ task was to detect mispronunciations. Word-initial phonemes were either fricatives or plosives, generating two experimental conditions (expect-fricative and expect-plosive). In the pre-word interval, significant differences (α = 0.05) emerged between conditions both for fixed and variable delays. Source reconstruction of this effect showed a brain-wide network involving several frequency bands, including bilateral superior temporal areas commonly associated with phonological processing, in a theta range. These results show that phonological representations supported by the theta band may be active before word onset, even under temporal uncertainty. However, in the evoked response just prior to the word, differences between conditions were apparent under variable- but not fixed-delays. This suggests that additional top-down mechanisms sensitive to phonological form may be recruited when there is uncertainty in the signal.
Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species
Authors: Zhao Yanding , Zurawel Ashley A. , Jenkins Nicole P. , Duennwald Martin L. , Cheng Chao , Kettenbach Arminja N. , Supattapone Surachai 
Published: June 2018

AbstractHuntington’s disease is caused by the pathological expansion of a polyglutamine (polyQ) stretch in Huntingtin (Htt), but the molecular mechanisms by which polyQ expansion in Htt causes toxicity in selective neuronal populations remain poorly understood. Interestingly, heterologous expression of expanded polyQ Htt is toxic in Saccharomyces cerevisiae cells, but has no effect in Schizosaccharomyces pombe, a related yeast species possessing very few endogenous polyQ or Q/N-rich proteins. Here, we used a comprehensive and unbiased mass spectrometric approach to identify proteins that bind Htt in a length-dependent manner in both species. Analysis of the expanded polyQ-associated proteins reveals marked enrichment of proteins that are localized to and play functional roles in nucleoli and mitochondria in S. cerevisiae, but not in S. pombe. Moreover, expanded polyQ Htt appears to interact preferentially with endogenous polyQ and Q/N-rich proteins, which are rare in S. pombe, as well as proteins containing coiled-coil motifs in S. cerevisiae. Taken together, these results suggest that polyQ expansion of Htt may cause cellular toxicity in S. cerevisiae by sequestering endogenous polyQ and Q/N-rich proteins, particularly within nucleoli and mitochondria.
Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response
Authors: Dvornikov D. , Schneider M. A. , Ohse S. , Szczygieł M. , Titkova I. , Rosenblatt M. , Muley T. , Warth A. , Herth F. J. , Dienemann H. , Thomas M. , Timmer J. , Schilling M. , Busch H. , Boerries M. , Meister M. , Klingmüller U. 
Published: June 2018

AbstractIn lung cancer a deregulation of Transforming Growth Factor-β (TGFβ) signaling has been observed. Yet, the impact of TGFβ in squamous cell carcinoma of the lung (LUSC) remained to be determined. We combined phenotypic and transcriptome-wide studies and showed that the stimulation of the LUSC cell line SK-MES1 with TGFβ results in an increase of migratory invasive properties. The analysis of the dynamics of gene expression by next-generation sequencing revealed that TGFβ stimulation orchestrates the upregulation of numerous motility- and actin cytoskeleton-related genes. Among these the non-muscle myosin 10 (MYO10) showed the highest upregulation in a LUSC patient cohort of the Cancer Genome Atlas (TCGA). Knockdown of MYO10 abrogated TGFβ-induced collagen gel invasion of SK-MES1 cells. The analysis of MYO10 mRNA expression in paired tissues of 151 LUSC patients with corresponding 80-month clinical follow-up data showed that the mRNA expression ratio of MYO10 in tumor and tumor-free tissue is prognostic for overall survival of LUSC patients and predictive for the response of these patients to adjuvant chemotherapy. Thus, MYO10 represents a new clinical biomarker for this aggressive disease and due to its role in cellular motility and invasion could serve as a potential molecular target for therapeutic interventions in patients with LUSC.
Controlled Defect Based Ultra Broadband Full-sized Metamaterial Absorber
Authors: Tran Manh Cuong , Le Dinh Hai , Pham Van Hai , Do Hoang Tung , Le Dac Tuyen , Dang Hong Luu , Vu Dinh Lam 
Published: June 2018

AbstractMetamaterial full-sized absorber structures are numerically and experimentally investigated in GHz region and then examined in THz frequency. By manipulating monitoring the number and the position of the defect elements in conventional unit cells, the optimal integrative absorber structures are generated. The proposed structures provide an ultra-broadband absorbance in the operating frequency. The good agreement between simulation, measurement and theoretical analysis is observed with a 5 GHz-bandwidth corresponding to the absorption of 95%. In particular, we extrapolate the concept to THz region and demonstrate that, the method can be applied to increase the bandwidth of the metamaterial absorber to 5 THz, while maintaining the other characteristics. This structure can be applied to improve the performance of telecommunication systems such as micro-antenna, micro-electromagnetic transmitters and apply to imaging and sensing fields.
Wearable activity monitors to assess performance status and predict clinical outcomes in advanced cancer patients
Authors: Gresham Gillian , Hendifar Andrew E. , Spiegel Brennan , Neeman Elad , Tuli Richard , Rimel B. J. , Figlin Robert A. , Meinert Curtis L. , Piantadosi Steven , Shinde Arvind M. 
Published: June 2018

AbstractAn objective evaluation of patient performance status (PS) is difficult because patients spend the majority of their time outside of the clinic, self-report to providers, and undergo dynamic changes throughout their treatment experience. Real-time, objective activity data may allow for a more accurate assessment of PS and physical function, while reducing the subjectivity and bias associated with current assessments. Consenting patients with advanced cancer wore a wearble activity monitor for three consecutive visits in a prospective, single-cohort clinical trial. Provider-assessed PS (ECOG/Karnofsky) and NIH PROMIS® patient-reported outcomes (PROs) were assessed at each visit. Associations between wearable activity monitor metrics (steps, distance, stairs) and PS, clinical outcomes (adverse events, hospitalizations, survival), and PROs were assessed using correlation statistics and in multivariable logistic regression models. Thirty-seven patients were evaluated (54% male, median 62 years). Patients averaged 3700 steps, 1.7 miles, and 3 flights of stairs per day. Highest correlations were observed between average daily steps and ECOG-PS and KPS (r = 0.63 and r = 0.69, respectively p < 0.01). Each 1000 steps/day increase was associated with reduced odds for adverse events (OR: 0.34, 95% CI 0.13, 0.94), hospitalizations (OR: 0.21 95% CI 0.56, 0.79), and hazard for death (HR: 0.48 95% CI 0.28–0.83). Significant correlations were also observed between activity metrics and PROs. Our trial demonstrates the feasibility of using wearable activity monitors to assess PS in advanced cancer patients and suggests their potential use to predict clinical and patient-reported outcomes. These findings should be validated in larger, randomized trials.
Hemorrhagic Cholecystitis after Warfarin Use for Deep Vein Thrombosis
Authors: Donn Eric , Atkinson Ian , McCague Andrew 
Published: June 2018

AbstractHemorrhagic cholecystitis is an uncommon form of acute cholecystitis which can be rapidly fatal. It may be hard to detect as it frequently presents with symptoms found in other, more common diagnoses. We report the case of a 63 year old man recently started on anticoagulation for deep vein thrombosis who was found to have hemorrhagic cholecystitis.
Semantic and lexical processing of words across two languages in Chinese-English bilinguals
Authors: Ma Fengyang , Ai Haiyang , Guo Taomei 
Published: June 2018

Abstract
The present fMRI study examined the neural correlates of semantic and lexical processing in unbalanced Chinese-English bilinguals with two lexical decision tasks in both their languages. Results showed that when contrasted the participants’ responses to words with those of pseudo-words, there was no significant difference between the first language (L1) and the second language (L2), suggesting that comparable neural networks are involved in semantic processing during word recognition in unbalanced bilinguals’ two languages. However, when contrasted the neural activation patterns of words and cross strings (i.e., ++++), the weaker L2 elicited stronger activation in the left middle occipital gyrus, the left precentral gyrus, and the right superior parietal lobule, relative to the dominant L1. This indicates that more resources are engaged in lexical processing in the L2 than in the L1.
Subunit priming effects on lexical decision in Korean
Authors: Bae Sungbong , Pae Hye K. , Yi Kwangoh 
Published: June 2018

Abstract
There have been conflicting results in the literature regarding the dominant linguistic unit (body-coda units vs. onset-rime units) in reading Korean Hangul. In an attempt to resolve the contradictory views between the phonotactic constraint (support for body-coda) and the universal rime bias (support for onset-rime) in reading, this chapter examines subunit priming effects on rapid word recognition among native Korean readers. Thirty five university students participated in a lexical decision task using Korean words and nonwords as targets. Primes included related and unrelated bodies, rimes, and consonants of disyllabic targets. Results of a linear mixed model showed that both body and rime units played significant roles in response time. Rime primes also affected accuracy of rapid lexical decision. Unlike previous research that showed body primacy, the results indicated that both body and rime units are important in reading Korean.
On the relationship between Arabic Foreigner Talk and Pidgin Arabic
Authors: Avram Andrei A. 
Published: June 2018

Abstract
The paper compares morphosyntactic and lexical features of the Arabic Foreigner Talk register to those of four Arabic-lexifier
pidgins, Pidgin Madame, Jordanian Pidgin Arabic, Romanian Pidgin Arabic, and Gulf Pidgin Arabic. The comparative overview
identifies a relatively significant number of features which Arabic Foreigner Talk shares with all or with at least some of
these Arabic-lexifier pidgins. The paper proposes an account in terms of a feedback relationship whereby Arabic Foreigner Talk
and Pidgin Arabic reinforce one another in the occurrence of these features.
Signal-anchor sequences are an essential factor for the Golgi-plasma membrane localization of type II membrane proteins
Authors: Kikegawa Tatsuki , Yamaguchi Takuya , Nambu Ryohei , Etchuya Kenji , Ikeda Masami , Mukai Yuri 
Published: June 2018

ABSTRACT
Despite studies of the mechanism underlying the intracellular localization of membrane proteins, the specific mechanisms by which each membrane protein localizes to the endoplasmic reticulum, Golgi apparatus, and plasma membrane in the secretory pathway are unclear. In this study, a discriminant analysis of endoplasmic reticulum, Golgi apparatus and plasma membrane-localized type II membrane proteins was performed using a position-specific scoring matrix derived from the amino acid propensity of the sequences around signal-anchors. The possibility that the sequence around the signal-anchor is a factor for identifying each localization group was evaluated. The discrimination accuracy between the Golgi apparatus and plasma membrane-localized type II membrane proteins was as high as 90%, indicating that, in addition to other factors, the sequence around signal-anchor is an essential component of the selection mechanism for the Golgi and plasma membrane localization. These results may improve the use of membrane proteins for drug delivery and therapeutic applications.
Effects of active site residues of 3α-hydroxysteroid dehydrogenase from pseudomonas sp. b-0831 on its catalysis and cofactor binding
Authors: Shiota Ayako , Inaba Satomi , Oda Masayuki 
Published: June 2018

ABSTRACT
We overexpressed and purified 3α-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831 (Ps3αHSD) and its mutants where the active site residues known as the SYK triad, Ser114, Tyr153, and Lys157, were mutated. Ps3αHSD catalyzes the reaction by using a nucleotide cofactor. The NADH binding affinity of K157A mutant was much lower than that of the wild-type, mainly due to loss of a hydrogen bond. The decreased affinity would result in decreased kcat. Compared to the wild-type, the mutants S114A and Y153F showed higher Km and lower kcat values in both oxidation and reduction reactions. Simultaneous mutation of S114A and Y153F resulted in a significant decrease in kcat relative to the single mutant. These results are supported by the notion that Tyr153 is a catalytic base and Ser114 would be a substitute. Loss of hydrogen bonding with NADH upon the Y153F mutation resulted in increased enthalpy change, partially compensated by increased entropy change.
Lycii fructus extract ameliorates hydrogen peroxide-induced cytotoxicity through indirect antioxidant action
Authors: Xu Wensi , Saiki Shunya , Myojin Takumi , Liu Yujia , Zhu Beiwei , Murata Yoshiyuki , Ashida Hitoshi , Tsunenaga Makoto , Nakamura Yoshimasa 
Published: June 2018

ABSTRACT
Lycii Fructus is the dried ripe fruits of Lycium chinense and L. barbarum, which has long been used as a traditional food material in East Asia. The purpose of this study was to investigate the role of the indirect antioxidative action in the Lycii fructus extract (LFE)-induced cytoprotective effect in vitro. LFE significantly enhanced the expression of the drug-metabolizing enzyme genes and intracellular glutathione level in mouse hepatoma Hepa1c1c7 cells. LFE stimulated the nuclear translocation of aryl hydrocarbon receptor as well as nuclear factor (erythroid-derived 2)-like 2. The pretreatment of LFE for 24 h, but not for 30 min, completely inhibited the cytotoxic effect of hydrogen peroxide. Furthermore, chlorogenic acid, one of the main constituents of LFE, showed cytoprotection against hydrogen peroxide with the enhanced phase 2 enzyme gene expression. These results suggested that LFE exhibits a cytoprotective effect, possibly through the enhancement of the antioxidant gene expression.
abbreviations: LFE: Lycii Fructus extract; GSH: glutathione; NQO1: NAD(P)H:quinone oxidoreductase 1; HO-1: heme oxygenase-1; GCLC: glutamate-cysteine ligase, catalytic subunit; xCT: a component of cysteine/glutamate antiporter (cystine/glutamate exchanger); CYP1A1: cytochrome P450 1A1; GSH: glutathione; AhR: aryl hydrocarbon receptor; Nrf2: nuclear factor (erythroid-derived 2)-like 2; CGA: chlorogenic acid; RT-PCR: reverse transcription-polymerase chain reaction; DTT: dithiothreitol; PMSF: phenylmethylsulfonyl fluoride; ARE: antioxidant response element; XRE: xenobiotic responsive element.
Reverse-engineering flow-cytometry gating strategies for phenotypic labelling and high-performance cell sorting
Authors: Becht Etienne , Simoni Yannick , Coustan-Smith Elaine , Evrard Maximilien , Cheng Yang , Ng Lai Guan , Campana Dario , Newell Evan W 
Published: June 2018

Abstract

Motivation
Recent flow and mass cytometers generate datasets of dimensions 20 to 40 and a million single cells. From these, many tools facilitate the discovery of new cell populations associated with diseases or physiology. These new cell populations require the identification of new gating strategies, but gating strategies become exponentially more difficult to optimize when dimensionality increases. To facilitate this step, we developed Hypergate, an algorithm which given a cell population of interest identifies a gating strategy optimized for high yield and purity.

Results
Hypergate achieves higher yield and purity than human experts, Support Vector Machines and Random-Forests on public datasets. We use it to revisit some established gating strategies for the identification of innate lymphoid cells, which identifies concise and efficient strategies that allow gating these cells with fewer parameters but higher yield and purity than the current standards. For phenotypic description, Hypergate’s outputs are consistent with fields’ knowledge and sparser than those from a competing method.

Availability and implementation
Hypergate is implemented in R and available on CRAN. The source code is published at http://github.com/ebecht/hypergate under an Open Source Initiative-compliant licence.

Supplementary information
Supplementary data are available at Bioinformatics online.
Stress Impairs Episodic Retrieval by Disrupting Hippocampal and Cortical Mechanisms of Remembering
Authors: Gagnon Stephanie A , Waskom Michael L , Brown Thackery I , Wagner Anthony D 
Published: June 2018

Abstract
Despite decades of science investigating the neural underpinnings of episodic memory retrieval, a critical question remains: how does stress influence remembering and the neural mechanisms of recollection in humans? Here, we used functional magnetic resonance imaging and multivariate pattern analyses to examine the effects of acute stress during retrieval. We report that stress reduced the probability of recollecting the details of past experience, and that this impairment was driven, in part, by a disruption of the relationship between hippocampal activation, cortical reinstatement, and memory performance. Moreover, even memories expressed with high confidence were less accurate under stress, and this stress-induced decline in accuracy was explained by reduced posterior hippocampal engagement despite similar levels of category-level cortical reinstatement. Finally, stress degraded the relationship between the engagement of frontoparietal control networks and retrieval decision uncertainty. Collectively, these findings demonstrate the widespread consequences of acute stress on the neural systems of remembering.
Consumer health-related needs of pregnant women and their caregivers
Authors: Robinson Jamie R , Anders Shilo H , Novak Laurie L , Simpson Christopher L , Holroyd Lauren E , Bennett Kelly A , Jackson Gretchen P 
Published: June 2018

Abstract

Objectives
To build effective applications, technology designers must understand consumer health needs. Pregnancy is a common health condition, and expectant families have unanswered questions. This study examined consumer health-related needs in pregnant women and caregivers and determined the types of needs that were not met.

Materials and Methods
We enrolled pregnant women &lt;36 weeks’ gestational age and caregivers from advanced maternal–fetal and group prenatal care settings. Participant characteristics were collected through surveys, and health-related needs were elicited in semi-structured interviews. Researchers categorized needs by semantic type and whether they were met (ie, met, partially met, or unmet). Inter-rater reliability was measured by Cohen’s kappa.

Results
Seventy-one pregnant women and 29 caregivers participated and reported 1054 needs, 28% unmet, and 49% partially met. Need types were 66.2% informational, 15.9% logistical, 8.9% social, 8.6% medical, and 0.3% other. Inter-rater reliability was near perfect (κ=0.95, P &lt; 0.001).

Discussion
Common topics of unmet needs were prognosis, life management, and need for emotional support. For pregnant women, these unmet needs focused around being healthy, childbirth, infant care, and being a good mother; caregivers’ needs involved caring for the mother, the natural course of pregnancy, and life after pregnancy.

Conclusion
Pregnant women and caregivers have a rich set of health-related needs with many not fully met. Caregivers’ needs differed from those of pregnant women and may not be adequately addressed by resources designed for mothers. Many unmet needs involved stress and life management. Knowledge about consumer health needs can inform the design of better technologies for pregnancy.
A Tribute to Dr Robert J. White
Authors: Lang Min , Tsiang John , Moore Nina Z , Bain Mark D , Steinmetz Michael P 
Published: June 2018

Abstract
Robert J. White is probably best known as the first neurosurgeon to perform successful “cephalic exchange” on monkeys in 1971. However, he was also a pioneer in the field of neurosurgery and contributed tremendously to the field of neuroanesthesia and bioethics. White received medical training at the University of Minnesota, Harvard University, Peter Bent Brigham Hospital, and Mayo Clinic before becoming the first Chief of Neurosurgery at Metrohealth Hospital in Cleveland, Ohio. He made significant strides in the field of spinal cord cooling and hypothermia. White and his team was also the first to successfully isolate the monkey brain with retention of biological activity. In 2004 and 2006, White and colleagues were nominated for the Nobel Prize in Physiology and Medicine, with Harvey Cushing and Wilder Penfield being the only other 2 neurosurgeons ever to be nominated for the award. Aside from his career as a neurosurgeon, he was also an advisor to 2 popes and an advocate for animal research. By the end of his career, White performed over 10 000 brain operations and published over 1000 articles, which has pushed the frontiers of neurosurgical research.
Recommendations From the Common Terminology Panel of the American Council of Academic Physical Therapy
Authors: Erickson Mia , Birkmeier Marisa , Booth Melissa , Hack Laurita M , Hartmann Julie , Ingram Debbie A , Jackson-Coty Janet M , LaFay Vicki L , Wheeler Emma , Soper Shawne 
Published: June 2018

Abstract

Background
In 2015, the American Council for Academic Physical Therapy (ACAPT) developed 3 strategic initiative panels to address integrated clinical education, student readiness, and common terminology for physical therapist clinical education.

Objective
The purpose of this paper is to describe the results of the work from the Common Terminology Panel.

Design
This was a descriptive, consensus-based study.

Methods
Using a consensus process and data that were collected from a review of literature, a document analysis of core and historical professional documents, focus group discussions, and an online open comment period, panel members developed a glossary for physical therapist clinical education.

Results
The final glossary included 34 terms in 4 categories. The categories included clinical education infrastructure, sites, stakeholders, and assessment. The ACAPT Board of Directors approved the glossary in June 2017, and the ACAPT membership approved the glossary in October 2017.

Limitations
The focus of the glossary was on physical therapist clinical education. A future, similar project should be undertaken for physical therapist assistant clinical education.

Conclusion
This process resulted in a comprehensive glossary for physical therapist clinical education; changes to several current terms, including “internship” and “full-time clinical education experience”; and the addition of new terms, including “preceptor” and “site coordinator for clinical education.” New terminology will provide standard language for consistent communication and a common framework for all stakeholders.