bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immediate bronchodilator response in FEV1as a diagnostic criterion for adult asthma
Authors: Tuomisto Leena E. , Ilmarinen Pinja , Lehtimäki Lauri , Tommola Minna , Kankaanranta Hannu 
Published: November 2018

Asthma is characterised by variable and reversible expiratory airflow limitations. Thus, it is logical to use the change in forced expiratory volume in 1 s (FEV1) in response to a bronchodilator (ΔFEV1BDR) as a diagnostic tool; increases of ≥12% and ≥200 mL from the baseline FEV1are commonly used values. We aimed to evaluate the historical development of diagnostic cut-off levels for the ΔFEV1BDR for adults and the evidence behind these recommendations.We searched for studies from the reference lists of all the main statements, reports and guidelines concerning the interpretation of spirometry and diagnostics for asthma and conducted a literature search.A limited amount of evidence regarding the ΔFEV1BDR in healthy populations was found, and even fewer patient studies were found. In healthy persons, the upper 95th percentile for the absolute ΔFEV1BDR ranges between 240 mL and 320 mL, the relative ΔFEV1BDR calculated from the initial FEV1ranges from 5.9% to 13.3% and the ΔFEV1BDR calculated from the predicted FEV1ranges from 8.7% to 11.6%. However, the absolute and percentage ΔFEV1BDR values calculated from the initial FEV1are dependent on age, sex, height and the degree of airway obstruction. Thus, the use of the ΔFEV1BDR calculated from the predicted FEV1might be more appropriate.Not enough data exist to assess the sensitivity of any of the cut-off levels for the ΔFEV1BDR to differentiate asthma patients from healthy subjects. Further studies in newly diagnosed asthma patients are needed.
Intra-breath measures of respiratory mechanics in healthy African infants detect risk of respiratory illness in early life
Authors: Gray Diane M. , Czovek Dorottya , McMillan Lauren , Turkovic Lidija , Stadler Jacob A.M. , Vanker Anessa , Radics Bence L. , Gingl Zoltán , Hall Graham L. , Sly Peter D. , Zar Heather J. , Hantos Zoltán 
Published: November 2018

Lower respiratory tract illness (LRTI) is a leading cause of mortality and morbidity in children. Sensitive and noninvasive infant lung function techniques are needed to measure risk for and impact of LRTI on lung health. The objective of this study was to investigate whether lung function derived from the intra-breath forced oscillation technique (FOT) was able to identify healthy infants at risk of LRTI in the first year of life.Lung function was measured with the novel intra-breath FOT, in 6-week-old infants in a South African birth cohort (Drakenstein Child Health Study). LRTI during the first year was confirmed by study staff. The association between baseline lung function and LRTI was assessed with logistic regression and odds ratios determined using optimal cut-off values.Of the 627 healthy infants with successful lung function testing, 161 (24%) had 238 LRTI episodes subsequently during the first year. Volume dependence of respiratory resistance (ΔR) and reactance (ΔX) was associated with LRTI. The predictive value was stronger if LRTI was recurrent (n=50 (31%): OR 2.5, ΔX), required hospitalisation (n=38 (16%): OR 5.4, ΔR) or was associated with wheeze (n=87 (37%): OR 3.9, ΔX).Intra-breath FOT can identify healthy infants at risk of developing LRTI, wheezing or severe illness in the first year of life.
High COPD prevalence at high altitude: does household air pollution play a role?
Authors: Brakema Evelyn A. , Tabyshova Aizhamal , Kasteleyn Marise J. , Molendijk Eveline , van der Kleij Rianne M.J.J. , van Boven Job F.M. , Emilov Berik , Akmatalieva Meerim , Mademilov Maamed , Numans Mattijs E. , Williams Sian , Sooronbaev Talant , Chavannes Niels H. 
Published: November 2018

Studies comparing chronic obstructive pulmonary disease (COPD) prevalence across altitudes report conflicting results. However, household air pollution (HAP), a major COPD risk factor, was mostly not accounted for in previous analyses and never objectively measured. We aimed to compare the prevalence of COPD and its risk factors between low-resource highlands and lowlands, with a particular focus on objectively measured HAP.We conducted a population-based, observational study in a highland (∼2050 m above sea level) and a lowland (∼750 m above sea level) setting in rural Kyrgyzstan. We performed spirometry in randomly selected households, measured indoor particulate matter with an aerodynamic diameter <2.5 µm (PM2.5) and administered a questionnaire on other COPD risk factors. Descriptive statistics and multivariable logistic regressions were used for analyses.We included 392 participants: 199 highlanders and 193 lowlanders. COPD was more prevalent among highlanders (36.7%versus10.4%; p<0.001). Their average PM2.5exposure was also higher (290.0versus72.0 µg·m−3; p<0.001). In addition to high PM2.5exposure (OR 3.174, 95% CI 1.061–9.493), the altitude setting (OR 3.406, 95% CI 1.483–7.825), pack-years of smoking (OR 1.037, 95% CI 1.005–1.070) and age (OR 1.058, 95% CI 1.037–1.079) also contributed to a higher COPD prevalence among highlanders.COPD prevalence and HAP were highest in the highlands, and were independently associated. Preventive interventions seem warranted in these low-resource, highland settings. With this study being one of the first spirometry-based prevalence studies in Central Asia, generalisability needs to be assessed.
Reconstructing ancient architecture at Tiwanaku, Bolivia: the potential and promise of 3D printing
Authors: Vranich Alexei 
Published: November 2018

Abstract
The ruins of Tiwanaku (A.D. 500–950), in the modern republic of Bolivia, present an archaeological challenge owing to intense looting during the colonial period that effectively demolished the site. One building in particular, known as the Pumapunku, was described by Spanish conquistadors and travelers of the sixteenth and seventeenth centuries, as a wondrous, though unfinished, building with gateways and windows carved from single blocks. Unparalleled in the pre-Colombian New World, the craftsmanship of this masonry has long been considered the architectural apogee of Andean pre-Colombian lithic technology. Unfortunately, during the last 500 years, treasure hunters have ransacked this building to the point that none of approximately shattered remains of 150 blocks of the standing architecture are to be found in their original place. Over the last century and a half, several different scholars have carefully measured the shattered architecture and even managed to join several fragments to form complete pieces. This research revisited these historic field notes with a view to transforming this century and a half of documentation into solid 3D form. These measurements were entered by hand into an architectural modeling program; the virtual form was subsequently printed in 3D form at 4% reduced scale. Unlike large architectural pieces — or notes or models on a computer screen — 3D-printed pieces can be manipulated quickly and intuitively, allowing researchers to try combinations and seek connections rapidly, turning over pieces and testing possible fits. This tactile engagement, along with the ability to quickly try out combinations of the 3D-printed pieces, led to fresh and often unexpected insights. Once refined and simplified, this methodology, was demonstrated to the indigenous site managers who were provided with a full copy of the printed architectural fragments with a view to continuing research and to present the work to visitors, stakeholders and other scholars.
Faktor yang Berhubungan dengan Deteksi Dini Kanker Serviks Metode IVA di Puskesmas Kota Padang
Authors: Aprianti Aprianti , Fauza Miftahil , Azrimaidalisa Azrimaidalisa 
Published: November 2018

Background: In 2013 the prevalence of cervical cancer in West Sumatra was 0.9 per 1000 population. This data exceeds the Indonesian prevalence of 0.8 per 1000 population. Lack of public knowledge regarding early detection of cervical cancer is the cause of the high prevalence of cervical cancer. This study aims to determine the factors associated with the participation of women of childbearing age in the early detection of VIA method cervical cancer in Padang City Health Center in 2018.Method: This study was a cross sectional design, conducted from February to October 2018. The population was women who visited the Alai Health Center and Pegambiran Health Center with a total sample were 110 respondents. The sampling method uses consecutive sampling method. Data collection by interview using a questionnaire. Data were analyzed by Chi-square statistical test and logistic regression with 95% confidence degree.Result: The results showed that 60% of respondents had never done the early detection of VIA cervical cancer method. Statistical test results show there was a significant relationship between the level of knowledge (p = 0,000), attitude (p = 0,041), access to information (p = 0,000) and husband's support (p = 0,000) with the early detection of VIA cervical cancer method. The results of multivariate analysis showed that the most dominant variables affected the participation of women in early detection of cervical cancer, namely husband's support (p = 0,000) and POR = 46,693.
Phenolic acids and antioxidant activity of wheat species: a review
Authors: Leváková Ľudmila , Lacko-Bartošová Magdaléna 
Published: November 2018

Abstract
Wheat (genus Triticum) is considered to be an important source of polyphenols, plant secondary metabolites with numerous health-promoting effects. Many phytochemicals are responsible for the high antioxidant activity of whole grain products. However, there is a lack of information about composition of phenolic acids and their concentrations in different Triticum species. Despite the fact that the increased consumption of whole grain cereals and whole grain-based products has been closely related to reduced risk of chronic diseases, bioactive compounds found in whole grain cereals have not achieved as much attention as the bioactive compounds in vegetables and fruits. Recent studies have revealed that the content of bioactive compounds and antioxidant capacity of whole grain cereals have been regularly undervalued in the literature, because they contain more polyphenols and other phytochemicals than was reported in the past. Phenolic acids represent a large group of bioactive compounds in cereals. These compounds play a significant role in the possible positive effects of the human diet rich in whole grain cereals, especially in wheat and provide health benefits associated with demonstrably diminished risk of chronic disease development. Ferulic acid, the primary and the most abundant phenolic acid contained in wheat grain, is mainly responsible for the antioxidant activity of wheat, particularly bran fraction. In this paper, selected phenolic compounds in wheat, their antioxidant activity and health benefits related to consumption of whole grain cereals are reviewed.
Uptake and Translocation of Some Heavy Metals by Rice Crop (Oryza sativa) in Paddy Soils
Authors: Rahimi Ghasem , Kolahchi Zahra , Charkhabi Amin 
Published: November 2018

Abstract
Accumulation of heavy metals in edible crops is amongst major international concerns today. While consuming Lenjan variety of rice is very popular in Iran, limited evidence exists on its safety. Amid increasing public concern about the safety of locally grown and imported rice in the market, a field study was carried out to investigate uptake and translocation of Cd, Pb, Ni, and Zn by a local variety of rice crop (Oryza sativa) exposed to contaminated water. At harvest time and in paddy fields, 41 soil and plant samples were collected from four locations of Lenjan, central Iran; irrigated from Zayandeh Rood River. In the laboratory, different parts of the plant were milled, digested via acid digestion method, and then analysed for Cd, Pb, Ni and Zn using atomic absorption spectrophotometry. The results showed that average concentrations of Cd, Pb, Ni and Zn were 1.07, 17.22, 1.73 and 13.75 mg/kg in the plant’s stem; and 1.27, 12.32, 1.099 and 19.39 mg/kg in its grain, respectively. In general, both in the plant’s stem and grain, the Cd and Pb concentrations were much higher than the FAO/WHO standard and labelled as harmful for consumers. Moreover, among the studied heavy metals, Ni transported very weakly, while Cd and Zn conveyed most easily into the plant’s stem and grain. Of course, Pb was the least mobile metal. However, it had highly accumulated in the plant’s stem and grain.
Effect of Supercritical Carbon Dioxide on Dyeability and Physical Properties of Ultra-High-Molecular-Weight Polyethylene Fiber
Authors: Ma Jaehyuk , Elmaaty Tarek Abou , Okubayashi Satoko 
Published: November 2018

Abstract
Supercritical carbon dioxide dyeing, a new type of anhydrous dyeing method, has a lot of advantages, mainly conservation of energy, prevention of pollution, reusability of dye, and many more. This study presents a viable method for the dyeing of an ultra-high-molecular-weight polyethylene (UHMWPE) fabric by using supercritical carbon dioxide (scCO2) as a medium. Five hydrozono propanenitrile dyes that are functional colorants having antibacterial activity were applied for the dyeing of the UHMWPE fabric in scCO2 at a pressure of 20 MPa and at temperature of 120°C. The dyeability of UHMWPE fabric under scCO2 was evaluated by color measurement, whereby the color strength K/S was calculated. As the treating time and concentration of dye increased, the dyeability of the UHMWPE fabric displayed the tendency to continually improve. As decaline was added into scCO2 as the cosolvent, we obtained higher K/S. Furthermore, color fastness to rubbing and sublimation of the dyed UHMWPE fabric were determined according to Japanese Industrial Standards (JIS) L 0849 2 and JIS L 0854, and the trend showed that the increase in fastness corresponded to the increase in duration of the treatment. The influence of scCO2 dyeing on the mechanical properties of UHMWPE was also examined. Consequently, it was found that dyeing in scCO2 containing decaline reduced the crystallinity of the UHMWPE fabric and the breaking strength decreased. The antimicrobial property of UHMWPE dyed with N′-(2-chloro-4-methylphenyl)-2-oxo-2-(p-tolyl)acetohydrazonoyl cyanide was tested against three different microorganisms, and the results have been reported.
Synthetic biology of B cell activation: understanding signal amplification at the B cell antigen receptor using a rebuilding approach
Authors: Kulathu Yogesh , Zuern Christa , Yang Jianying , Reth Michael 
Published: November 2018

Abstract
Upon activation of the B cell antigen receptor (BCR), the spleen tyrosine kinase (Syk) and the Src family kinase Lyn phosphorylate tyrosines of the immunoreceptor tyrosine-based activation motif (ITAM) of Igα and Igβ which further serve as binding sites for the SH2 domains of these kinases. Using a synthetic biology approach, we dissect the roles of different ITAM residues of Igα in Syk activation. We found that a leucine to glycine mutation at the Y+3 position after the first ITAM tyrosine prevents Syk binding and activation. However, a pre-activated Syk can still phosphorylate this tyrosine in trans. Our data show that the formation of a Syk/ITAM initiation complex and trans-ITAM phosphorylation is crucial for BCR signal amplification. In contrast, the interaction of Lyn with the first ITAM tyrosine is not altered by the leucine to glycine mutation. In addition, our study suggests that an ITAM-bound Syk phosphorylates the non-ITAM tyrosine Y204 of Igα only in cis. Collectively, our reconstitution experiments suggest a model whereby first trans-phosphorylation amplifies the BCR signal and subsequently cis-phosphorylation couples the receptor to downstream signaling elements.
Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1
Authors: Fan Linbing , Joseph Jan Felix , Durairaj Pradeepraj , Parr Maria Kristina , Bureik Matthias 
Published: November 2018

Abstract
The human cytochrome P450 enzyme CYP8B1 is a crucial regulator of the balance of cholic acid (CA) and chenodeoxycholic acid (CDCA) in the liver. It was previously shown to catalyze the conversion of 7α-hydroxycholest-4-en-3-one, a CDCA precursor, to 7α,12α-dihydroxycholest-4-en-3-one, which is an intermediate of CA biosynthesis. In this study we demonstrate that CYP8B1 can also convert CDCA itself to CA. We also show that five derivatives of luciferin are metabolized by CYP8B1 and established a rapid and convenient inhibitor test system. In this way we were able to identify four new CYP8B1 inhibitors, which are aminobenzotriazole, exemestane, ketoconazole and letrozole.
Synthesis, crystal structure and properties of Cd(NCS)2 coordination compounds with two different Cd coordination modes
Authors: Jochim Aleksej , Gallo Gianpiero , Dinnebier Robert , Näther Christian 
Published: November 2018

Abstract
Reaction of Cd(NCS)2 with 4-methoxypyridine leads to the formation of four new compounds, of which one crystallizes in two different polymorphs. In Cd(NCS)2(4-methoxypyridine)4·(4-methoxypyridine)2 (1) and Cd(NCS)2(4-methoxypyridine)4 (2-I and 2-II) discrete complexes are found, in which the Cd cations are octahedrally coordinated by four 4-methoxypyridine co-ligands and two terminally N-bonded thiocyanate anions. For the polymorphs 2-I and 2-II no single crystals are available and therefore, the corresponding Mn(II) compound (2-I-Mn) was prepared, which is isotypic to 2-I, as proven by a Rietveld refinement. The crystal structure of 2-II was solved and refined from XRPD data. In [Cd(NCS)2(4-methoxypyridine)2]
n
(3), the Cd cations are also octahedrally coordinated but linked into linear chains by pairs of thiocyanate anions with all ligands in trans-position. {[Cd(NCS)2]3(4-methoxypyridine)5}
n
(4) also consists of chains but two different Cd coordination modes are observed. Two of the three crystallographically independent Cd cations show an octahedral coordination with a trans- or cis-arrangement of the N and S atoms of the anionic ligands, whereas the third one is in a distorted square-pyramidal coordination, with cis-coordination of the thiocyanate N and S atoms. Measurements using simultaneous thermogravimetry and differential scanning calorimetry of 2-I and 2-II show different heating rate dependent mass steps, in which the co-ligands are removed. In some of the residues obtained after the respective TG steps compound 3 was detected but no phase pure samples could be obtained.
Modulated vacancy ordering in SrGe6−

x
(x≈0.45)
Authors: Schwarz Ulrich , Castillo Rodrigo , Wosylus Aron , Akselrud Lev , Prots Yurii , Wahl Bernhard , Doert Thomas , Bobnar Matej , Grin Yuri 
Published: November 2018

Abstract
The structural properties of modulated SrGe6−

x
(x≈0.45) were investigated by means of single-crystal and powder X-ray diffraction combined with quantum chemical calculations. The framework compound SrGe6−

x
adopts a defect variant of the EuGa2Ge4-type crystal structure. Samples of the binary compound with nominal compositions 0≤x≤0.5 were synthesized at pressures from 5 to 6 GPa and a temperature of typically 1400 K. The product reveals diffraction peaks of the EuGa2Ge4-type subcell plus additional reflections indicating an ordered superstructure. Detailed crystal structure analysis evidences the incommensurate nature of the superstructure and a modulation of the vacancy ordering in the germanium network. The computations have shown that the non-stoichiometric composition of the framework with its local defect organization affects the calculated charge of the strontium anions. Although the chemical composition is close to a charge-balanced situation, temperature-dependent resistivity measurements showed metal-type conductivity. At ambient pressure SrGe6−

x
decomposes exothermally and irreversibly at T=680(10) K into SrGe2 and germanium, indicating its metastable nature at ambient pressure.
Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe
Authors: Yukawa Masashi , Yamada Yusuke , Toda Takashi 
Published: November 2018

Abstract
The Kinesin-5 motor Cut7 in Schizosaccharomyces pombe plays essential roles in spindle pole separation, leading to the assembly of bipolar spindle. In many organisms, simultaneous inactivation of Kinesin-14s neutralizes Kinesin-5 deficiency. To uncover the molecular network that counteracts Kinesin-5, we have conducted a genetic screening for suppressors that rescue the cut7-22 temperature sensitive mutation, and identified 10 loci. Next generation sequencing analysis reveals that causative mutations are mapped in genes encoding α-, β-tubulins and the microtubule plus-end tracking protein Mal3/EB1, in addition to the components of the Pkl1/Kinesin-14 complex. Moreover, the deletion of various genes required for microtubule nucleation/polymerization also suppresses the cut7 mutant. Intriguingly, Klp2/Kinesin-14 levels on the spindles are significantly increased in cut7 mutants, whereas these increases are negated by suppressors, which may explain the suppression by these mutations/deletions. Consistent with this notion, mild overproduction of Klp2 in these double mutant cells confers temperature sensitivity. Surprisingly, treatment with a microtubule-destabilizing drug not only suppresses cut7 temperature sensitivity but also rescues the lethality resulting from the deletion of cut7, though a single klp2 deletion per se cannot compensate for the loss of Cut7. We propose that microtubule assembly and/or dynamics antagonize Cut7 functions, and that the orchestration between these two factors is crucial for bipolar spindle assembly.
EFFECT OF CAPILLARY PRESSURE IN NANOBUBBLES ON THEIR ADHERENCE TO PARTICLES DURING FROTH FLOATATION. PART 6. INFORMATIVITY OF BUBBLE SPREADING CURVES
Authors: Melik-Gaikazyan V. I. , Emel’yanova N. P. , Dolzhenkov D. V. 
Published: November 2018

Spreading curves (SCs) are calculated for bubble diameters (de) 1 mm and 1 μm on substrates with different wettability: from maximumhydrophobicity (Г) to maximum-hydrophilicity (Ф) as well as incompletely wettable (Нх) ones, where x = 0,8; 0,6; 0,4 and 0,2 is the fraction of an ionized collector monolayer under the bubble. The calculations were based on the results of a numerical solution of the Laplace equation in the form of 12-figure tables such as Bashforth and Adams tables. They demonstrate firstly that the SCs obtained are identical to those calculated for bubbles with de = 20 and 10 nm, and thus SC shapes are unchanged in the 105 range, i.e. virtually for all flotation bubbles, and secondly that SC shapes and their mutual arrangement depend on substrate wettability. Spreading curves clearly illustrate the advantages of substrate Г adhesion to the bubble in comparison with substrate Ф, and for Нх an advantage of the substrate with a larger fraction of x. It is quantitatively shown that even with small spreading of nanobubbles adhered to the particle, their adherence force increases billion times so that large bubbles can fix on their increased perimeters and lead the particle to flotation. If, however, the adhesion of large bubbles to nanobubbles occurs before spreading of the latter, they will come off together, and the particle will not float. This mechanism was used for particle flotation in the processes of the Bessel brothers, Potter-Delpra and two processes of F. Elmor in the late 19th and early 20th centuries. The prospect of increasing the productivity and cost-efficiency of modern froth flotation by activating particle flotation not only with nanobubbles but also with larger bubbles is considered.