bluuebunny/crossref_metadata_2025_split huggingface dataset:
Justicia constitucional y polarización política en EspañaConstitutional justice and political polarization in Spain
Authors: Simón Yarza Fernando 
Published: November 2024

Abstract
Established in 1980, the Spanish Constitutional Court displayed a pacifying function and remained in a discreet position, relatively immune to external polarization, during its first years of existence. Already in the first decade, certain signs of polarization began to appear. However, the last fifteen years have witnessed an increasing polarization around the Court. This is mainly due to exogenous causes, which have produced a change in the very self-understanding of the Court. The article begins with some conceptual clarifications, in order to highlight the inherent balance of Constitutional Justice. The author then devotes an epigraph to examine the practices that have contributed to polarization from the outside (distribution of appointments by quotas, transfer of social polarization, excessive recusals, political criticism and direct legislative disturbance of its peaceful functioning). Thirdly, he refers to the judicial practices that, as a consequence of the external intervention, seem to have fed back the polarization (leaks, delays, public exposure of the judges and overreaching of jurisdiction). The author concludes with some more general reflections on the relationship between the external and internal causes of polarization around the Court.
The Lexicographic Process Revisited
Authors: Klosa-Kückelhaus Annette , Tiberius Carole 
Published: November 2024

Abstract
Lexicographic practice is changing and so is the lexicographic process. This article therefore reconsiders the lexicographic process and takes into account the development towards centralised lexicographical databases which can be observed at lexicographic institutions and dictionary publishing houses in the last couple of years. We discuss how this affects the lexicographic process and its phases and how the process could be further changed by the systematic use of LLMs in lexicography or the further involvement of dictionary users in the process. The paper concludes by emphasizing the need for continuously observing the lexicographic process and redefining it if necessary.
Pilferage risk and selective pilfering of scatterhoarded food in Auburn, Alabama, United States
Authors: Ramirez Sarah B , Dobson F Stephen , Steury Todd D 
Published: November 2024

Abstract
Animals that experience a food-scarce season can supplement their diet by scatterhoarding, or burying food around their home range, and then retrieving and consuming those food items at a later date. Theft, or pilferage, is considered the greatest risk to stored food; yet little is known about the pilferage risk of different types of seeds. We investigated the long-term relative pilferage risk of 793 artificially scatterhoarded seeds (Mockernut Hickory, Carya tomentosa (Lam. Ex Poir.) Nutt.; American Beech, Fagus grandifolia Ehrh.; White Oak, Quercus alba L.; Water Oak, Quercus nigra L.) buried in Alabama from October 2020 to February 2021 and exposed to hoarding populations of eastern gray squirrels (Sciurus carolinensis Gmelin, 1788) and eastern chipmunks (Tamias striatus (L., 1758)). We found evidence that animals can selectively pilfer whole, dormant seeds and whole seeds were pilfered more rapidly than those with excised embryos. Whole Water Oak acorns were more likely to be pilfered than all other seed types. All seeds had a combined pilferage risk of 0.98 over 182 days, and the risks for individual seed types were all greater than 0.97. Our findings indicate the importance of pilferage reduction strategies documented in hoarding species and may indicate an advantage to having a diverse supply of hoarded foods that include lower-value seeds with lower pilferage risk.
International research collaboration in personalized medicine between Europe and Latin America and the Caribbean
Authors: Gómez-Núñez Antonio J , Perianes-Rodríguez Antonio , Sela Erika , Guinea Joaquín 
Published: November 2024

Abstract
An analysis of research collaboration in personalized medicine between European and Latin American and Caribbean countries has been conducted in order to identify significant aspects allowing such collaboration. It aims to comprehend strategic issues for establishing research collaborations in personalized medicine between the two regions, as well as the structural factors that facilitate the collaboration. An exhaustive literature review of the subject was the basis for the development of a framework covering several factors that are significant at different stages of the collaboration process. The framework assisted in developing a questionnaire and defining relevant questions for a final survey, which was sent to more than 1,800 corresponding authors of publications resulting from collaborations between European and Latin American and Caribbean researchers. The results point out interesting issues like the profile of the collaboration partners, types of research collaboration, factors and motivations favouring the participation in collaborative research, ways to contact partners, funding sources and tools, main outputs or principal barriers to collaboration. Due to the lack of available information on research collaborations in the field of personalized medicine, this type of analysis is valuable to support science and research policy-making and to evaluate the various actions, initiatives and projects carried out in this scenario. Although our methodology and analysis focused on the field of personalized medicine, the results obtained could be helpful to better understand the reality of international scientific collaborations and support the design of collaborative funding programmes in other fields.
A rapid and parallel Late Pleistocene/Holocene morphological radiation in a predaceous planktonic water flea: the case of Bythotrephes (Cladocera: Cercopagididae)
Authors: Karpowicz Maciej , Karabanov Dmitry , Świsłocka-Cutter Magdalena , Sługocki Łukasz , Whitmore-Stolar Elizabeth A , Connolly Joseph K , Watkins James M , Kotov Alexey A 
Published: November 2024

Abstract
The predatory cladoceran Bythotrephes is one of North America’s most successful and impactive invasive species in freshwater plankton communities. The taxonomic status of the genus Bythotrephes Leydig, 1860 (Crustacea: Cladocera: Cercopagididae) has remained unclear and a subject of intensive debate for over 150 years. We applied an integrative taxonomy approach with multi-gene analysis (mitochondrial COI and 12S genes, and nuclear 18S and 28S genes) on 80 individuals (representing at least four morphospecies) from various regions spanning the genus distribution (North America, Europe, and Asia) to resolve the taxonomic status of species within Bythotrephes. The results of our study strongly support the hypothesis of a single species—Bythotrephes longimanus Leydig, 1860, and ecological morphs should be accepted as junior synonyms. Our work also elucidates the very recent radiation of Bythotrephes, which may have begun rapidly and parallel during the Late Pleistocene, or even after the last glaciation. Finally, we provide a comprehensive biogeographic reconstruction of Bythotrephes dispersal within the Holarctic realm. Europe likely served as a dispersal centre for Bythotrephes from where they spread relatively recently (possibly, less than 10 kyr) and we distinguish five possible dispersal events in its evolutionary history.
Breast relapse of myeloid sarcoma and SARS-CoV-2 infection following hematopoietic stem cell transplantation in mixed-phenotype acute leukemia: a case report
Authors: Hu Chaolu , Liu Hui , Zhao Song , Shang Mengmeng , Ma Rong , Dong Xiaoyuan , Zhu Jiang 
Published: November 2024

Abstract

Background
Mixed-phenotype acute leukemia is a rare, high-risk subtype of acute leukemia. Myeloid sarcoma is a localized tumor formed by the proliferation and infiltration of primitive or immature myeloid cells outside the bone marrow. It is often an extramedullary manifestation of acute myeloid leukemia, and imaging lacks specificity, leading to potential misdiagnosis.

Case Presentation
A female patient diagnosed with mixed-phenotype acute leukemia achieved complete remission after chemotherapy and allogeneic hematopoietic stem cell transplantation. However, a relapse occurred in the breast after transplantation. The patient achieved local control through mastectomy and removal of the axillary lymph nodes on the affected side. Unfortunately, during the subsequent course of chemotherapy, the patient died of a severe pulmonary infection caused by coronavirus disease 2019.

Conclusion
Continuous treatment and monitoring of mixed-phenotype acute leukemia patients are essential, especially for those with extramedullary manifestations (such as breast involvement).
Efficacy comparison of repeated low-level red-light therapy and orthokeratology lenses for myopia control
Authors: Sun Jing-Ru , Du Zhi-Qiang , Wu Gang-Yue 
Published: November 2024

SIGNIFICANCE
These findings suggest that repeated low-level red-light therapy holds potential as a new method for managing myopia in children.

PURPOSE
This study aimed to compare and analyze the efficacy of repeated low-level red-light therapy and orthokeratology lenses for myopia control in children.

METHODS
Exactly 138 participants were enrolled in this retrospective study. Comprehensive eye examinations were performed prior to treatment. The repeated low-level red-light therapy and orthokeratology lenses groups comprised 67 and 71 patients, respectively. The age range was between 6 and 14 years, with myopia of ≤−0.50 D and astigmatism of ≤2.50 D after cycloplegia. Follow-up data were collected during the initial visit and the treatment period. Changes in axial length over a 2-year period and associated factors were analyzed.

RESULTS
Over the 2-year period, the repeated low-level red-light therapy group exhibited significantly less axial length growth compared with the orthokeratology lenses group (0.17 ± 0.40 vs. 0.50 ± 0.27 mm, p<0.001). In the first year, the axial length growth in the repeated low-level red-light therapy group was significantly less than that in the orthokeratology lenses group (0.03 ± 0.22 vs. 0.28 ± 0.18 mm, p<0.001), with no significant difference observed in the second year (0.14 ± 0.29 vs. 0.21 ± 0.14 mm, p=0.06). The repeated low-level red-light therapy group showed a 55% reduction in axial length after 1 month and a 42% reduction after 1 year, compared with 4% and 3% reductions in the orthokeratology lenses group, respectively. Linear mixed-effects model analysis indicated that the annual axial length change rate in the repeated low-level red-light therapy group was 0.10 mm (95% confidence interval [CI], 0.07 to 0.14), compared with 0.25 mm in the orthokeratology lenses group (95% CI, 0.24 to 0.27), with an average difference of 0.15 mm (95% CI, −0.17 to −0.12, p<0.001).

CONCLUSIONS
Repeated low-level red-light therapy demonstrated slightly superior efficacy in controlling myopia progression in children compared with orthokeratology lenses.
Do previous contraceptive methods have an impact on postmenopausal women’s health? A questionnaire study
Authors: Tang Yun-Hui , He Yuan , Yao Xiao-Ying 
Published: November 2024

Objective:
This study aimed to investigate the relationship between previous contraceptive methods and postmenopausal health in older women.

Methods:
A questionnaire was administered to value the health status of women aged at least 65 years. Factors associated with general health and reproductive health were analyzed.

Results:
A total of 2746 older women were enrolled, and hypertension was the most common non-neoplastic disease (37.62%, 1033/2746) among the group. A total of 123 patients were diagnosed with postmenopausal neoplastic disease. Breast cancer was the most common malignancy among older women (37/123, 31%). Women in the ligation group had a lower incidence of hypertension (239/1033, 23.14%), and women in the intrauterine devices (IUDs) group had a higher incidence of postmenopausal human papillomavirus (HPV) infection (140/200, 70%). The incidence of breast cancer significantly decreased after tubal ligation (2/37, 5.4%), whereas women who used condoms had a significantly lower incidence of cervical cancer after menopause (2/26, 7.69%).

Conclusions:
Hypertension is a common condition among women aged 65 and older, and breast cancer is the most prevalent malignancy. Among women aged 65 and older, the incidence of hypertension and breast cancer was lower after tubal ligation. Cervical cancer is the most common gynecological malignancy in postmenopausal women. Women who used IUDs had a higher risk for HPV infection. The incidence of cervical cancer is significantly lower in women who used condoms compared to those who did not.
Reactive Astrocytes Promote Axonal Remodeling of the Corticospinal Tract During Neuronal Recovery Revealed by 18F-THK5351 PET
Authors: Hatakeyama Tetsuhiro , Kawai Nobuyuki , Maruo Tomoko , Norikane Takashi , Yamamoto Yuka , Miyake Keisuke 
Published: November 2024

Abstract
A teenager who suffered from left hemiparesis after traumatic brain injury underwent 18F-THK5351 PET 48, 286, and 810 days after the injury. The first scan showed slight uptake in the right corticospinal tract (CST), and the second scan showed intense uptake along the CST, which was significantly reduced in the third scan. The hemiparesis has improved between the first and second scans. 18F-THK5351 binds to monoamine oxidase B, which is expressed in reactive astrocytes (RAs). Recently, the beneficial role of RAs in plasticity and reconstruction after traumatic brain injury has been reported. 18F-THK5351 uptake may represent axonal remodeling accompanied with RAs in the CST.
Unexpected Radioiodine Uptake in 131I Whole-Body Scan
Authors: Yang Biao , Lv Yuhu , Zhang Xiao , Shao Fuqiang , Lan Xiaoli 
Published: November 2024

Abstract
A 23-year-old woman underwent a near-total thyroidectomy approximately 4 months prior due to papillary carcinoma. To eliminate residual thyroid tissue, she was administered 130 mCi of 131I during her initial radioiodine therapy session. After receiving therapy for 3 days, a focus of radioiodine uptake was noted in the left pelvic cavity on the posttherapy 131I whole-body image. Further analysis using SPECT/CT imaging pinpointed the uptake to the left ovary. Histopathological findings confirmed the presence of a mature teratoma in the ovary.
FDG PET Images of Pseudoprogression After Nivolumab-FOLFOX Chemotherapy in a Gastric Cancer Patient
Authors: Lee Yeongjoo , Won Hye Sung , Seo Kyung Jin , Na Sae Jung 
Published: November 2024

Abstract
A 60-year-old man diagnosed with gastric adenocarcinoma underwent FDG PET/CT. After completing 9 cycles of combination chemotherapy with nivolumab and FOLFOX, he had multiple new nodular uptakes in the bilateral cervical chains and mediastinum. The pathology of the right neck node confirmed reactive lymph node hyperplasia without evidence of malignancy, suggesting pseudoprogression after immunotherapy. It is worthwhile to report these PET image patterns, as they could significantly influence clinical decision-making.
Measuring positive health using the My Positive Health (MPH) and Individual Recovery Outcomes Counter (I.ROC) dialogue tools: a panel study on measurement properties in a representative general Dutch population
Authors: van Druten Vera P. , Metz Margot J. , Mathijssen Jolanda J.P. , van de Mheen Dike , van Vliet Marja , Rudd Bridey , de Vries Esther , Nahar– van Venrooij Lenny M.W. 
Published: November 2024

ABSTRACTIntroductionUsing the ‘positive health’ perspective has emerged in general healthcare. Conceptual similarities exist with the ‘recovery’ perspective in mental healthcare. Both concepts are multidimensional and focus on capability. The My Positive Health (MPH) and Individual Recovery Outcomes Counter (I.ROC) tools were developed fordialogues. These tools might be useful forquantitively measuringthepositive healthconstruct for monitoring and scientific purposes as well. We aimed to investigate this.MethodAn observational cross-sectional study was conducted in a representative general Dutch population (the LISS panel) to investigate factor structures and internal consistency from the 42-items MPH and 12-items I.ROC. After randomly splitting the dataset, exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were applied. Spearman correlation coefficient between both tools’ total scores was calculated.Results2,457 participants completed the questionnaires. A six-factor structure was extracted for MPH (PH42) and a two-factor structure for I.ROC (I.ROC12). Explained variances were 68.1% and 56.1%, respectively. CFA resulted in good fit indices. Cronbach’s alphas were between 0.74 to 0.97 (PH42) and 0.73 to 0.87 (I.ROC12). Correlation between the total scores was 0.77.ConclusionBoth PH42 and I.ROC12 are useful to quantitatively measure positive health aspects which can be summarised in sum scores in a general population. The dimensions found in this study and the corresponding item division differed from the dimensions of the original dialogue tools. Further research is recommended focussing on item reduction for PH42, factor structure of I.ROC and assessment of construct validity (in a general population) in more depth.
Pro-ictal, rather than pre-ictal, brain state marked by global critical slowing and local gamma power increase
Authors: Dallmer-Zerbe I. , Kopal J. , Pidnebesna A. , Curot J. , Denuelle M. , De Barros A. , Sol J.C. , Valton L. , Barbeau E.J. , Hlinka J. 
Published: November 2024

ABSTRACTThe clinical workup during the pre-surgical evaluation for epilepsy relies on the electrophysiological recording of spontaneous seizures. The interval until first seizure occurrence is characterized by an increase in seizure likelihood caused by progressive drug dose decreases, during which the epileptic brain transitions from a state of low to a state of high seizure likelihood, so-calledpro-ictalstate. This study aimed to identify the dynamic brain changes characteristic of this transition from 386 ten-minute segments of intracranial EEG recordings of 29 patients with drug-refractory temporal lobe epilepsy, explored by stereoelectroencephalography, irregularly sampled between electrode implantation and first seizure. As measures of brain dynamics we studied mean phase coherence and relative power in the gamma frequency band, and autocorrelation function width. We further investigate the interaction of those brain dynamics with various susceptibility factors, such as the rate of interictal spikes and high frequency oscillations, circadian and multi-day cycles, and clinical outcomes. We observed a significant increase in relative gamma power in the epileptogenic zone, and an increase in critical slowing in both the epileptogenic zone as well as in presumably healthy cortex. These brain dynamic changes were linked with increases in spike and high frequency oscillations rate. While brain dynamic changes occurred on the slow time scale - from the beginning to the end of the multi-day interval - they did not change in the short-term during the pre-ictal interval. We thus highlight gamma power and critical slowing indices as markers of pro-ictal (as opposed to pre-ictal) brain states, as well as their potential to track the seizure-related brain mechanisms during the presurgical evaluation of epilepsy patients.Key PointsWe investigated the multi-day changes in brain dynamics during presurgical evaluation of patients with drug-resistant temporal lobe epilepsy, inside the epileptogenic zone as well as in healthy brain tissue.This time interval of increasing seizure susceptibility is marked by increases in gamma band power in the epileptogenic zone and network-wide increase in critical slowing.The identified multi-day changes were consistently linked to the changes in spikes and high-frequency oscillations (HFOs), while not to other factors like drug dose and circadian time.While gamma power and critical slowing changed on the scale of days, there was no significant increase in the minutes before seizures, suggesting the brain dynamic changes during presurgical evaluation are likely a multi-day phenomenon associated with pro-ictal states.
When is the R = 1 epidemic threshold meaningful?
Authors: Parag Kris V , Cori Anne , Obolski Uri 
Published: November 2024

AbstractTheeffective reproduction number Ris a predominant statistic for tracking the transmissibility of infectious diseases and informing public health policies. An estimatedR=1is universally interpreted as indicating epidemic stability and is a critical threshold for deciding whether new infections will grow (R>1) or fall (R<1). We demonstrate that this threshold, which is typically computed over coarse spatial scales, rarely signifies stability because those scales integrate infections from heterogeneous groups. Groups with falling and rising infections counteract and early-warning signals from resurging groups are lost in noisy fluctuations from stable groups with large infection counts. We prove that an estimatedR=1is consistent with a vast space of epidemiologically diverse scenarios, diminishing its predictive power and policymaking value. We show that a recent statistic,E, derived fromRvia experimental design theory provides a more meaningful stability threshold (E=1) by rigorously constraining this space of scenarios.
Racial and Ethnic Disparities in Prescribing of GLP-1 Receptor Agonists in the United States: A Retrospective Cohort Analysis
Authors: Kukhareva Polina V. , Facelli Julio C. , O’Brien Matthew J. , Gouripeddi Ram , Kawamoto Kensaku , Zhang Yue , Reddy Deepika , Malone Daniel C 
Published: November 2024

AbstractBackgroundType 2 diabetes (T2D) represents a major public health burden in the United States, with racial disparities in medication use potentially exacerbating inequities in health outcomes. This study examined racial/ethnic differences in the prescription of high-efficacy glucose-lowering medications for T2D using a large EHR network (TriNetX).MethodsA retrospective cohort study included adults with uncomplicated T2D (ICD-10: E11.9), categorized as Hispanic or Latino (Hispanic) or non-Hispanic American Indian/Alaska Native (AI/AN), Asian, Black, Native Hawaiian/Pacific Islander (NH/PI), and White. Adjusted odds ratios for GLP-1 receptor agonist medications (tirzepatide, semaglutide, and dulaglutide) prescriptions in 2022-2023 were calculated by race/ethnicity, controlling for age, sex, and Charlson Comorbidity Index.FindingsAmong 57,320 patients included in the analysis, we observed significant racial disparities in the prescribing of GLP-1 medications. Compared to White patients, for tirzepatide, adjusted odds ratios prescriptions were 0.6 (95% CI: 0.4-0.9) for AI/AN, 0.3 (95% CI: 0.3-0.4) for Asian, 0.7 (95% CI: 0.6-0.9) for Black, 0.4 (95% CI: 0.3-0.5) for Hispanic, and 0.4 (95% CI: 0.3-0.6) for NH/PI. For semaglutide, adjusted odds ratios were 0.8 (95% CI: 0.7-0.9) for AI/AN, 0.5 (95% CI: 0.5-0.6) for Asian, 0.8 (95% CI: 0.7-0.9) for Black, 0.6 (95% CI: 0.6-0.7) for Hispanic, and 0.6 (95% CI: 0.5-0.8) for NH/PI. For dulaglutide, adjusted odds ratios were 1.2 (95% CI: 1.0-1.4) for AI/AN, 0.5 (95% CI: 0.4-0.5) for Asian, 1.0 (95% CI: 0.9-1.1) for Black, 0.9 (95% CI: 0.8-1.0) for Hispanic, and 0.5 (95% CI: 0.4-0.6) for NH/PI.InterpretationRacial disparities in high-efficacy diabetes medication prescriptions may contribute to unequal health outcomes in T2D, highlighting the need for targeted research and interventions for equitable diabetes care.