bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatty Acids Related Genes Expression Undergo Substantial Changes in Porcine Oviductal Epithelial Cells During Long-Term Primary Culture
Authors: Budna Joanna , Celichowski Piotr , Knap Sandra , Jankowski Maurycy , Magas Magdalena , Nawrocki Mariusz J. , Ramlau Piotr , Nowicki Andrzej , Rojewska Magdalena , Chermuła Błażej , Jeseta Michal , Antosik Paweł , Bukowska Dorota , Bruska Małgorzata , Zabel Maciej , Nowicki Michał , Kempisty Bartosz 
Published: September 2018

Abstract
The process of reproduction requires several factors, leading to successful fertilization of an oocyte by a single spermatozoon. One of them is the complete maturity of an oocyte, which is acquired during long stages of folliculogenesis and oogenesis. Additionally, the oviduct, composed of oviductal epithelial cells (OECs), has a prominent influence on this event through sperm modification and supporting oocyte’s movement towards uterus. OECs were isolated from porcine oviducts. Cells were kept in primary in vitro culture for 30 days. After 24h and on days 7, 15 and 30 cells were harvested, and RNA was isolated. Transcript changes were analyzed using microarrays. Fatty acids biosynthetic process and fatty acids transport ontology groups were selected for analysis and described. Results of this study indicated that majority of genes in both ontology groups were up-regulated on day 7, 15 and 30 of primary in vitro culture. We analyzed genes involved in fatty acids biosynthetic process, including: GGT1, PTGES, INSIG1, SCD, ACSL3, FADS2, FADS1, ACSS2, ALOX5AP, ACADL, SYK, ACACA, HSD17B8, FADS3, OXSM, and transport, including: ABCC2, ACSL4, FABP3, PLA2G3, PPARA, SYK, PPARD, ACACA and P2RX7. Elevated levels of fatty acids in bovine and human oviducts are known to reduce proliferation capacity of OECs and promote inflammatory responses in their microenvironment. Most of measured genes could not be connected to reproductive events. However, the alterations in cellular proliferation, differentiation and genes expression during in vitro long-term culture were significant. Thus, we can treat them as putative markers of changes in OECs physiology.
The Montreal Convention of 1999 and Regulation No 261/2004 in the EUCJ and National Case Law
Authors: Deviatnikovaitė Ieva 
Published: September 2018

Abstract
The article first analyses the relationship between the Montreal Convention and Regulation 261/2004. Although the Regulation and the Convention both relate to the protection of air passenger’s rights it remains ambiguous when and in which disputes these acts should be applicable. Thus, this article reveals the problematical issue of how these acts differ and in which situations they are applicable. Second, it reviews the development of the EUCJ case law regarding the application of these acts. Third, it examines the relevant case law of the Supreme Court of the Republic of Lithuania in this area.
AGRONOMIC MANAGEMENT SYSTEMS FOR REHABILITATION AND SUSTAINED CROP PRODUCTION IN COASTAL AGRO ECOSYSTEM OF TAMIL NADU
Authors: V. MULLAIVENDHAN R. REX IMMANUEL, M. THIRUPPATHI, 
Published: September 2018

Field experiments were conducted in the degraded coastal agro ecosystem with different land management methods and ameliorative amendments such as to boost the growth of identified MPT’s in degraded soil. The field experiment were laid out in split plot design and consisted of 16 treatment combinations with four land management treatment in the main plots (M1-pit method, M2-trench method , M3-mound method and M4-Auger hole method) and four ameliorative treatment in sub plots (S1-FYM @ 12.5 t ha-1 + Gypsum @ 200 kg ha-1+ ZnsO4 @ 25 kg ha-1 + Azospirillum @ 2kg ha-1+ Phosphobacteria @ 2 kg ha-1, S2- Pressmud @ 15 t ha-1+ Gypsum @ 200 kg ha-1+ ZnsO4 @ 25 kg ha-1+ Azospirillum @ 2kg ha-1 + Phosphobacteria @ 2 kg ha-1, S3– Composted coir pith @ 10 t ha-1 + Gypsum @ 200 kg ha-1 + ZnsO4 @ 25 kg ha-1 + Azospirillum @ 2 kg ha-1+Phosphobacteria @ 2 kg ha-1 and S4- no amendments). The treatment was replicated three times for the identified MPT’s of Pongamia pinnata Based on the results of present study it can be clearly found that trench method of planting in combination with FYM @ 12.5 t ha-1, Gypsum @ 200 kg ha-1, ZnsO4 @ 25 kg ha-1, Azospirillum @ 2 kg ha-1 and phosphobacteria @ 2 kg ha-1 recorded the highest establishment percentage height, girth, PGR and taproot length of identified MPT’s of Pongamia pinnata n the degraded coastal soil.
SISTEM PENGENDALIAN INTERNAL, FRAUD DIAMOND, DAN LARCENY SEBAGAI EFEK MEDIASI WHISTLEBLOWINGSYSTEM (STUDI PADA BPK RI)
Authors: Krystella Krystella , Sitorus Tigor 
Published: September 2018

This research is aim to determine the effect of internal control system, fraud diamond, and whistleblowingsystem on larceny at BPK RI. Research data was obtained through questionnaires distributed torespondent, the employees in the work unit of General Bureau, IT Bureau, Human Resources Bureau and Leaders Secretariat Bureau BPK RI. So as many as 105 samples collected. This research used quantitative analysis technique with Structural Equation Modeling (SEM) processed with Amos 23. The test results showed : 1) Internal control system variable has positive and significant influence on whistleblowingsystem, 2) fraud diamond variable has not significant influence on whistleblowingsystem, 3) whistleblowingsystem variable has negative and significant influence on larceny, 4) internal control system variable has not significant influence on larceny, 5) fraud diamond variable has positive and significant influence on larceny. Therefore, the whistleblowingsystem mediation effect of the internal control system influence on larceny is perfectly significant. While the effect of fraud diamond on larceny is not proven to mediate.
ANALISIS PENGARUH PROFITABILITAS, UKURAN PERUSAHAAN, LEVERAGE, DAN PENGUNGKAPAN SOSIAL TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2011-2015
Authors: Setiawati Loh Wenny 
Published: September 2018

Economic growth that affects the welfare of the people can be pursued by investing. Investors will be interested to invest when the value of the company is high. Corporate value is an important concept for investors, because it is an indicator for the market to assess the company as a whole. This study aims to examine the effect of profitability, firm size, leverage, and social disclosure of corporate value. This research uses purposive sampling method in conducting sample selection. The statistical method used to test the hypothesis is multiple linear regression analysis. This study uses 81 manufacturing industry companies listed on the Indonesia Stock Exchange in the period 2011-2015. The results of this study indicate that profitability, firm size, leverage, and social disclosure affect the value of the company.
Vitamin D in non-alcoholic fatty liver disease (NAFLD)
Authors: Chueansuwan Rachaneeporn 
Published: October 2018

Vitamin D is increasingly accepted as an important physiological regulator of several organ systems apart from its classical role in skeletal homeostasis. In recent years, new scientific discoveryon vitamin D expands our knowledge of its actions in many aspects such as immune modulation, cell differentiation and proliferation, and inflammatory regulations. Vitamin D deficiency is one of the mostcommon micronutrient deficiencies worldwide. Non-alcoholic fatty liver disease (NAFLD) and vitamin D deficiency often coexist. In addition, epidemiologic evidence has shown that both conditions shareseveral cardio-metabolic risk factors. While pre-clinical experimental data is promising, most clinical trials based on the effect of vitamin D in NASH are under-powered and inconclusive. Further studiesare required to elucidate the beneficial effect of vitamin D or its analogues in NASH. In this article, we provide an overview of the epidemiology and pathophysiology linking NAFLD and vitamin D deficiency,as well as the available evidence on the clinical utility of vitamin D supplementation in NAFLD.
Figure 1 แสดงวิตามินดีเมตาบอลิสม์ (ดัดแปลงจากเอกสารอ้างอิง Hossein-Nezhad and Holick (12))
PENAMPILAN 10 AKSESI TALAS (Colocasio esculenta (L). Schott) DI LAHAN PESISIR BENGKULU
Authors: Simamora Ramalan Manahara , Yulian Yulian , Turmudi Edhi 
Published: September 2018

Talas (Colocasio esculenta (L). Schott) merupakan salah satu komoditas pangan yang belum termanfaatkan secara maksimal. Potensi komoditas tersebut belum didukung dengan data yang baik. Untuk menggali potensi yang dimiliki tanaman talas perlu dilakukan pendataan sifat pentingnya dengan melakukan karakterisasi. Karakterisasi dapat dilakukan berdasarkan karakter morfologi dan fisiologi tanaman. Penelitian ini bertujuan untuk mengidentifikasi penampilan 10 genotipe talas pada fase vegetatif di lahan pesisir. Penelitian ini dilaksanakan pada bulan Juni sampai Agustus 2015 di Kelurahan Sukamerindu, Kecamatan Sungai Serut, Kota Bengkulu dengan ketinggian tempat + 14 m dpl. Penelitian ini menggunakan Rancangan Acak Kelompk Lengkap (RAKL) dengan 10 genotipe talas dan masing-masing perlakuan diulang 3 kali sehingga diperoleh total 30 unit percobaan dengan total 240 tanaman. Hasil penelitian menunjukkan bahwa secara morfologi talas dikelompokkan berdasarkan warna batang (Putih : genotipe T2, T4, T5, T6, T7, T8 dan T9, pink pucat : genotipe T1, T3, orange kemerah mudaan : genotipe T10), warna daun (Hijau : genotipe T2, T3, T4, T5, T6, T8, T9 dan T10, hijau tua : T7, hijau keunguan : T1), bentuk daun (perisai : genotipe T1, T6, delta : genotipe T2, T3, T7, Oval : genotipe T5, T8, T9 dan T10, hati : genotipe T4), ujung daun (Runcing: genotipe T1, T2, T3, T4, T9, T10, tumpul : genotipe T5, T6, T7, bundar : genotipe T8) tepi daun (Bergelombang : genotipe T1, T2, T3, T5, T6, T8, T9, T10, rata : genotipe T4,T7), dan warna tangkai daun (Hijau : genotipe T2, T4, T10, hijau kekuningan : genotipe T5,T8,T9, hijau kebiruan : genotipe T7, hijau keunguan : genotipe T3, T6, hitam : genotipe T1). Terdapat beda sangat nyata antar 10 genotipe talas dalam hal tinggi tanaman, tingkat kehijauan daun, diameter batang semu dan jumlah anakan.
Changing goals in the management of breast carcinoma patients towards preservation of feminity and quality of life
Authors: Pathak Soumi , Bhargava Ajay Kumar 
Published: October 2018

Breast cancer is the commonest cancer in women worldwide. In the developing countries of Asia, the health care burden on account of breast cancer has been steadily mounting. Over 100,000 new breast cancer patients are estimated to be diagnosed annually in India.1 As per the ICMR-PBCR data, breast cancer is the commonest cancer among women in urban registries of Delhi, Mumbai, Ahmedabad, Calcutta, and Trivandrum where it constitutes > 30% of all cancers in females. Previous literature on mastectomy indicates that the operation may be perceived by the patient as a threat to her feminity. Breast cancer survivors have dissatisfaction with appearance, perceived loss of femininity and body integrity, self-consciousness about appearance, and dissatisfaction with surgical scars… Journal of Society of Anesthesiologists of NepalVol. 4, No. 2, 2017, Page: 96-98
MAVİSEL YENER’İN ÇOCUK KİTAPLARINDA SÖZLÜ EDEBİYAT ÜRÜNLERİ
Authors: ANAZ Zehra 
Published: September 2018

Her
çocuk bulunduğu ortamın kültür özelliklerine göre dilini geliştirir. Dile bağlı
olarak da değer ve davranış geliştirir. Dil öğrenimi, eğitimi aynı
zamanda bir kültür aktarımı olduğu için her topluluk kültürünü dilin yardımıyla
yeni kuşaklara taşır. Böylelikle sözlü ve yazılı anlatım ile gerçekleştirilen
halk edebiyatı ürünleri çocuğun dil eğitimine önemli ölçüde katkıda bulunur.

Masal,
destan, efsane, ninni, türkü, tekerleme, mani, bilmece, fıkra, halk şarkıları
çocuğun gerek dil bilinci gerekse kültür oluşturmasında etkili ürünlerdir.
Çocuk edebiyatı, kökleri geçmişe dayalı yüzyıllık birikime sahip bu ürünleri
göz önünde bulundurmaktadır.

Çocuk
kitapları yazarı olarak tanınan, çocuklara okumayı sevdirmek amacında olan bir
yazar olarak karşımıza çıkan Mavisel Yener’in bu ürünlere yatkınlığı ve konuyu
çocuk gözüyle aktarımı hemen her kitabında göze çarpmaktadır. Mavisel Yener'in
çocuk diliyle yazdığı öyküler, masallar çocukların dünyaya gülümseyerek ve
hoşgörü ile bakmalarına yardımcı olabilecek, onlara okumayı ve kitabı
sevdirebilecek türdendir.

Çocukları
anadilin söz varlığıyla tanıştıran Mavisel Yener’in eserleriyle sınırlandırılan
çalışmada kitaplar; sözlü edebiyat
ürünlerinin çocuk ve gençlik edebiyatıyla ilişkisi göz önünde bulundurularak
aktarılması bakımından kapsamlı olarak incelenecektir. Bu çalışmayla
Mavisel Yener’in eserlerinin çocuk edebiyatı-sözlü edebiyat ilişkisi kapsamında
kullanılabilirliğini tespit etmek amaçlanmaktadır. İnceleme; detaylı okuma,
fişleme ve tasnif faaliyetinin ürünüdür.

Araştırmanın
sonunda yapılan analizler sonucunda, “sözlü edebiyat ürünlerinin çocuk ve
gençlik edebiyatına Mavisel Yener’in eserleri örneğinde aktarılması”
değerlendirilecek ve araştırmada elde edilen bulgulardan yola çıkılarak Mavisel
Yener’in eserlerinin sözlü edebiyat ürünleriyle
ilişkisi kapsamında dil ve anlatım yönünden materyal olarak kullanılması
hususunda öneriler getirilecektir.
Awake-craniotomy for cavernoma resection
Authors: Pamias-Portalatin Eva , Duran Ivan Segura , Ebot James , Bojaxhi Elird , Tatum William , Quiñones-Hinojosa Alfredo 
Published: October 2018

Cavernomas make up approximately 8%–15% of all intracranial vascular malformations, and the most common presenting symptom is seizures. Complete resection of the cavernoma and removal of the surrounding gliotic core presents a cure but poses a challenge if an eloquent brain is involved or with incomplete resection of the epileptogenic foci. The authors present the case of a 53-year-old man with intractable seizures from a left posterior temporal lobe cavernoma who underwent an awake craniotomy with intraoperative seizure monitoring via electrocorticography.The video can be found here: https://youtu.be/vxaikozg2g4.
Awake craniotomy for right inferior lobule glioma
Authors: Leal Rafael T. M. , Landeiro Jose A. 
Published: October 2018

Awake craniotomy is a method usually used for brain tumors near or within language and/or sensorimotor areas. Preservation of these important neurological functions, however, may not be enough for a normal life. The authors present a case of a 45-year-old woman with an inferior parietal lobule low-grade glioma who underwent an awake craniotomy with sensorimotor and spatial cognition mapping.The video can be found here: https://youtu.be/HMA_pZYg3Ms.
Mapping visuospatial and self-motion perception functions in the left parietal lobe
Authors: Velásquez Carlos , Goméz Elsa , Martino Juan 
Published: October 2018

Parietal lobe functions include somesthesia, language, calculation, self-motion perception, and visuospatial awareness. In this video, the authors show the intraoperative mapping of a left parietal lobe for a low-grade glioma resection. Standard sensory and language mapping were performed. Interestingly, by using the “Line Bisection” task, subcortical stimulation of the gyrus angularis was repeatedly associated with ipsilateral spatial neglect, often described in the right parietal lobe. In a similar way, subcortical stimulation in a more posterior point elicited episodes of vertigo, probably due to stimulation of the superior longitudinal fasciculus. Both findings were useful to define the functional limit of the resection.The video can be found here: https://youtu.be/qgGDRW_6u0A.
Contralateral interhemispheric, transfalcine approach with asleep motor mapping for parasagittal lesions near the medial precentral gyrus
Authors: Mooney Michael A. , Sanai Nader 
Published: October 2018

The contralateral interhemispheric approach has several advantages for approaching parasagittal lesions, including lesions involving or approaching the medial precentral gyrus. Supplementing the interhemispheric approach with asleep motor mapping is useful for confirming the location of the corticospinal tracts from the contralateral transfalcine corridor and identifying subcortical motor fibers at the deep aspect of the resection cavity. The authors describe the contralateral interhemispheric, transfalcine approach with asleep motor mapping to resect a parasagittal metastatic lesion involving the medial precentral gyrus.The video can be found here: https://youtu.be/L-fJ6m5kOWs.
nTMS guidance of awake surgery for highly eloquent gliomas
Authors: Ille Sebastian , Gempt Jens , Meyer Bernhard , Krieg Sandro M. 
Published: October 2018

Navigated transcranial magnetic stimulation (nTMS) allows for preoperative mapping for eloquent gliomas. Besides surgical planning, it also guides intraoperative stimulation mapping. The authors’ routine includes preoperative nTMS plus nTMS-based tractography for motor and language to consult patients, plan surgery, craniotomy, and guide cortical and subcortical stimulation.Here, the authors present this routine in a 48-year-old woman with a glioma of the left middle and superior frontal gyrus reaching the precentral gyrus and superior longitudinal fascicle. Gross-total resection via awake surgery was achieved without deficit.The nTMS data and nTMS-based tractography augment eloquent glioma management far beyond its current application.The video can be found here: https://youtu.be/h4ldgMXL1ys.
Causes, clinical presentation, management, and outcomes of chronic subdural hematoma at Mbarara Regional Referral Hospital
Authors: Kitya David , Punchak Maria , Abdelgadir Jihad , Obiga Oscar , Harborne Derek , Haglund Michael M. 
Published: October 2018

OBJECTIVECauses, clinical presentation, management, and outcomes of chronic subdural hematoma (CSDH) in low- and middle-income countries are not well characterized in the literature. Knowledge regarding these factors would be beneficial in the development and implementation of effective preventive and management measures for affected patients. The authors conducted a study to gain a better understanding of these factors in a low-income setting.METHODSThis prospective study was performed at Mbarara Regional Referral Hospital (MRRH) in Uganda between January 2014 and June 2017. Patients of any age who presented and were diagnosed with CSDH during the aforementioned time period were included in the study. Variables were collected from patients’ files at discharge and follow-up clinic visits. The primary outcome of interest was death. Secondary outcomes of interest included discharge Glasgow Coma Scale (GCS) score, ICU admission, wound infection, and CSDH recurrence.RESULTSTwo hundred five patients, the majority of whom were male (147 [72.8%]), were enrolled in the study. The mean patient age was 60.2 years (SD 17.7). Most CSDHs occurred as a result of motor vehicle collisions (MVCs) and falls, 35.6% (73/205) and 24.9% (51/205), respectively. The sex ratio and mean age varied depending on the mechanism of injury. Headache was the most common presenting symptom (89.6%, 173/193), whereas seizures were uncommon (11.5%, 23/200). Presenting symptoms differed by age. A total of 202 patients underwent surgical intervention with burr holes and drainage, and 22.8% (46) were admitted to the ICU. Two patients suffered a recurrence, 5 developed a postoperative wound infection, and 18 died. Admission GCS score was a significant predictor of the discharge GCS score (p = 0.004), ICU admission (p < 0.001), and death (p < 0.001).CONCLUSIONSTrauma from an MVC is the commonest cause of CSDH among the young. For the elderly, falling is common, but the majority have CSDH with no known cause. Although the clinical presentation is broad, there are several pronounced differences based on age. Burr hole surgery plus drainage is a safe and reliable intervention. A low preoperative GCS score is a risk factor for ICU admission and death.
Neural tube defects in Uganda: follow-up outcomes from a national referral hospital
Authors: Xu Linda W. , Vaca Silvia D. , He Joy Q. , Nalwanga Juliet , Muhumuza Christine , Kiryabwire Joel , Ssenyonjo Hussein , Mukasa John , Muhumuza Michael , Grant Gerald 
Published: October 2018

OBJECTIVEChildren with neural tube defects (NTDs) require timely surgical intervention coupled with long-term management by multiple highly trained specialty healthcare teams. In resource-limited settings, outcomes are greatly affected by the lack of coordinated care. The purpose of this study was to characterize outcomes of spina bifida patients treated at Mulago National Referral Hospital (MNRH) through follow-up phone surveys.METHODSAll children presenting to MNRH with NTDs between January 1, 2014, and August 31, 2015, were eligible for this study. For those with a documented telephone number, follow-up phone surveys were conducted with the children’s caregivers to assess mortality, morbidity, follow-up healthcare, and access to medical resources.RESULTSOf the 201 patients, the vast majority (n = 185, 92%) were diagnosed with myelomeningocele. The median age at presentation was 6 days, the median length of stay was 20 days, and the median time to surgery was 10 days. Half of the patients had documented surgeries, with 5% receiving multiple procedures (n = 102, 51%): 80 defect closures (40%), 32 ventriculoperitoneal shunts (15%), and 1 endoscopic third ventriculostomy (0.5%). Phone surveys were completed for 53 patients with a median time to follow-up of 1.5 years. There were no statistically significant differences in demographics between the surveyed and nonrespondent groups. The 1-year mortality rate was 34% (n = 18). At the time of survey, 91% of the survivors (n = 30) have received healthcare since their initial discharge from MNRH, with 67% (n = 22) returning to MNRH. Hydrocephalus was diagnosed in 29 patients (88%). Caregivers reported physical deficits in 39% of patients (n = 13), clubfoot in 18% (n = 6), and bowel or bladder incontinence in 12% (n = 4). The surgical complication rate was 2.5%. Glasgow Outcome Scale–Extended pediatric revision scores were correlated with upper good recovery in 58% (n = 19) of patients, lower good recovery in 30% (n = 10), and moderate disability in 12% of patients (n = 4). Only 5 patients (15%) reported access to home health resources postdischarge.CONCLUSIONSThis study is the first to characterize the outcomes of children with NTDs that were treated at Uganda’s national referral hospital. There is a great need for improved access to and coordination of care in antenatal, perioperative, and long-term settings to improve morbidity and mortality.