bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Nasal Testosterone Gel (Natesto®) Stratified by Baseline Endogenous Testosterone Levels
Authors: Gronski Matthew A , Grober Ethan D , Gottesman Irving S , Ormsby Ross W , Bryson Nathan 
Published: June 2019

AbstractObjectivePharmacokinetic and efficacy data from a phase 3 testosterone nasal gel (TNG) study were stratified by baseline endogenous testosterone level in patients with testosterone deficiency. Total testosterone (TT), LH, and FSH levels, as well as erectile function, mood, and lean body mass for each group were compared. In a subset of patients with very low baseline endogenous testosterone levels (&lt;100 ng/dL), we investigated whether TNG is a suitable treatment option.Materials and MethodsPatients with testosterone deficiency (serum TT &lt;300 ng/dL) were treated with TNG for 3 months, followed by safety extension periods of 90 and/or 180 days. Pharmacokinetic parameters were calculated from serum hormone levels on days 30 and 90, along with efficacy measurements, which were analyzed by comparison with baseline values. Baseline and/or predose TT values were used for patient stratification.ResultsPrestudy and predose endogenous testosterone concentrations correlated. The maximal concentration of TT was nearly identical across all cohorts at days 30 and 90, whereas the average concentration over 24 hours had a slight positive dependence relative to predose levels. LH levels remained in the normal range but were decreased more in patients with higher starting baseline levels. These findings indicate that TNG works with an active hypothalamic-pituitary-gonadal axis that responds to each dose of TNG throughout the treatment period. Patients with the lowest endogenous testosterone levels received maximum exposure impact from each TNG dose. Patients with severe testosterone deficiency had similar efficacy improvements as the remainder of the study population.ConclusionAll testosterone-deficient cohorts were successfully treated with TNG.
Novo CARF e planejamento tributário com operações societárias
Authors: Lopo Martinez Antonio , Oliveira João Pedro Earl Galvêas 
Published: June 2019

Quais são os critérios de validade relevantes nos julgamentos de um planejamento tributário no Novo CARF? A pesquisa coletou Acórdãos proferidos entre dezembro de 2015 a dezembro de 2017, envolvendo reestruturação societária, utilizando o método “normative systems” e regressões lineares, verificaram-se a significância de critérios de validade. Os resultados reiteram a importância do proposito negocial e da ausência de simulação, mas destacam características procedimentais que influenciam no resultado de um julgamento. Quem fez o voto vencedor condutor do Acórdão, se houve o voto de qualidade e o valor do crédito tributário, influenciam na validação ou invalidação do planejamento tributário.
MATERIALISMO, CIÊNCIA E METAFÍSICA EM MARX
Authors: Moura Gedeão Mendonça de 
Published: June 2019

Pretendo, neste artigo, tratar da relação entre materialismo, ciência e metafísica na obra de Marx, ainda que de forma bastante rápida. As questões que orientam esta exposição são as seguintes: mesmo se declarando um pensador materialista, Marx não seria ainda tributário da metafísica pelo fato de não abandonar por completo certas reminiscências metafísicas? Isso não gera uma incoerência no interior de sua nova concepção [materialista] de mundo, que éestabelecida justamente para se contrapor às muitas concepções idealistas de sua época, e pretende revelar a “única” e verdadeira “ciência da história” (MARX & ENGELS, 2007, p. 86)? Assim, o empreendimento teórico de Marx estaria apenas assentado sobre bases científicas, e tão afastado quanto possível do terreno da metafísica?
Persistent Postprandial Regurgitation vs Rumination in Patients With Refractory Gastroesophageal Reflux Disease Symptoms: Identification of a Distinct Rumination Pattern Using Ambulatory Impedance-pH Monitoring
Authors: Nakagawa Kenichiro , Sawada Akinari , Hoshikawa Yoshimasa , Nikaki Kornilia , Sonmez Shirley , Woodland Philip , Yazaki Etsuro , Sifrim Daniel 
Published: June 2019

OBJECTIVES:
Up to 20% of patients with refractory gastroesophageal reflux disease (GERD) might have postprandial rumination. The aim of this study was to distinguish persistent GERD-related postprandial regurgitation from rumination in patients with refractory GERD undergoing ambulatory multichannel intraluminal impedance–pH (MII-pH) monitoring.

METHODS:
We first characterized 24-hour and postprandial MII-pH patterns in 28 consecutive patients with confirmed rumination syndrome (positive clinical and high-resolution manometry/impedance). We compared such MII-pH patterns with those from 30 patients with typical GERD symptoms (10 nonerosive reflux disease, 10 hyperactive esophagus, and 10 functional heartburn) and 27 healthy controls. Using ROC curves, we selected the best MII-pH parameters to prepare an MII-pH rumination score. We prospectively tested the performance of the new MII-pH rumination score in 26 consecutive patients with refractory GERD (predominant regurgitation).

RESULTS:
Compared with GERD controls, patients with rumination were more often females, younger, and had significantly more postprandial early nonacid reflux episodes with high proximal extent. Postprandial reflux in ruminators had a distinct nadir pH profile over time (from nonacid to acid). Despite increased reflux events, baseline impedance in ruminators was similar to that in healthy subjects. Ruminators marked postprandial symptoms earlier and much more often than patients with GERD. An MII-pH–based rumination score (using postprandial nonacid reflux/hour and Symptom Index) diagnosed rumination in 46% of patients with refractory GERD and persistent regurgitation (sensitivity 91.7% and specificity 78.6%).

DISCUSSION:
Postprandial rumination is very common in refractory GERD with persistent regurgitation. A simple MII-pH score detects rumination in these patients with high sensitivity and specificity.
Effects of Islamic Spiritual Mindfulness on Stress among Nursing Students
Authors: Munif Badrul , Poeranto Sri , Utami Yulian Wiji 
Published: June 2019

Background: Academic stress is a major problem that often occurs in nursing students. Islamic spiritual mindfulness (ISM) is an adaptive coping strategy used to mitigate various negative psychological reactions to respond stressors experienced by the body to build self-awareness that any problems experienced today are the scenario of Allah.Purpose: This study aimed to determine the effects of Islamic spiritual mindfulness therapy to reduce stress.Methods: This study used a pre-post quasi-experimental design with a control group. Participants were bachelor students of nursing who are Muslim and experienced stress in working on the thesis (n=36) and were assigned to two groups: the experimental group receiving Islamic spiritual mindfulness and the control group. Data were collected using questionnaires of Depression Anxiety Stress Scale (DASS) and analyzed using paired t-test and unpaired t-test. Results: The results showed that the mean stress level of students in the intervention group decreased from 20.6±2.97 to 11.4±5.81 after the intervention. Meanwhile, in the control group, the mean student stress level slightly decreased from 19.7±2.82 to 17.8±5.01. The t-test obtained a p-value of 0.001, indicating that there were significant differences in stress levels between the intervention group and the control group. The effect size obtained the value of 0.59, meaning the level of influence was in the medium category.Conclusion: This study concluded that Islamic spiritual mindfulness was effective in reducing stress among nursing students working on the thesis. It is recommended for the nursing profession, especially mental health nurses, to apply Islamic spiritual mindfulness therapy as one of the psychotherapy interventions.
Effects of Spiritual Counseling on Spiritual Health-Quality of Life in Patients with HIV/AIDS
Authors: Hasanah Ulung , Ibrahim Kusman , Sriati Aat 
Published: June 2019

Background: HIV/AIDS is a chronic and progressive disease that has complex health problems which affect the quality of life. Patients with HIV/AIDS need spiritual support to increase their spiritual health. A more effective therapeutic approach using spiritual counseling is seen as effective for improving health in chronic conditions.Purpose: This study aimed to examine the effects of spiritual counseling on the quality of life-spiritual health in patients with HIV/AIDS.Methods: This study employed a pre-posttest quasi-experimental design with a control group. The samples were 30 patients each in the experimental group and the control group recruited using purposive sampling. The experimental group received three sessions of spiritual counseling intervention. Data of the quality of life-spiritual health were collected using the WHOQOL-SRPB BREF and analyzed using t-test with significance <0.05. Results: Results indicated significant differences in the spiritual health-quality of life between the control and experimental groups. The result of paired t-test before and after the intervention in the experimental group showed a p-value of <0.05, whereas in the control group, the p-value was >0.05. After the intervention, the p-value in the experimental and control groups was <0.05, indicating significant differences between the two groups.Conclusion: This study concluded that spiritual counseling interventions had an effect on increasing the quality of life-spiritual health in patients with HIV/AIDS. Thus, it is necessary for the hospital to consider the results of this study as one of the interventions in providing nursing care to HIV/AIDS patients.
Ligninases remove phenolic inhibitors and facilitate yeast growth in lignocellulosic hydrolysate
Authors: Chen Honglei , Zhao Xin , Liu Yu , Kong Fangong , Ji Xingxiang 
Published: June 2019

Abstract
Sugar-containing hydrolysates as byproducts of dissolving pulp production could be a source of alcohol production, but the presence of fermentation inhibitors hampers this utilization route. In the present study, nine types of phenolic inhibitors were found and their removal by ligninases gave satisfactory results. Laccase removed 73.1% of phenolic inhibitors and produced three new aromatic compounds, whereas the combination of laccase and lignin peroxidase (as a dual-enzyme treatment) resulted in a removal rate of 91.7% without new product formation. Xylose as the main sugar in the hydrolysate was retained with a 90% yield, regardless of the enzymatic treatment, which modified, however, the kinetics of yeast growth. Laccase improved cells’ maximum specific growth rate (v
max) from 0.115 to 0.154 and reduced the saturation constant (K
s

) from 53.4 to 42.5, whereas the dual-enzyme system improved v
max to 0.206 and reduced K
s

to 42.44. The greater v
max and the smaller K
s

imply a better growth rate, and accordingly, the dual-enzyme system is better suited for removing phenolic inhibitors.
Efficiency of TiO2 catalyst supported by modified waste fly ash during photodegradation of RR45 dye
Authors: Gilja Vanja , Katančić Zvonimir , Krehula Ljerka Kratofil , Mandić Vilko , Hrnjak-Murgić Zlata 
Published: June 2019

Abstract
The waste fly ash (FA) material was subjected to chemical treatment with HCl at elevated temperature for a different time to modify its porosity. Modified FA particles with highest surface area and pore volume were further used as a support for TiO2 catalyst during FA/TiO2 nanocomposite preparation. The nanocomposite photocatalysts were obtained by in situ sol–gel synthesis of titanium dioxide in the presence of FA particles. To perform accurate characterization of modified FA and FA/TiO2 nanocomposite photocatalysts, gas adsorption-desorption analysis, X-ray diffraction, scanning electron microscopy, UV/Vis and Infrared spectroscopy were used. Efficiency evaluation of the synthesized FA/TiO2 nanocomposites was performed by following the removal of Reactive Red 45 (RR45) azo dye during photocatalytic treatment under the UV-A irradiation. Photocatalysis has been carried out up to five cycles with the same catalysts to investigate their stability and the possible reuse. The FA/TiO2 photocatalyst showed very good photocatalytic activity and stability even after the fifth cycles. The obtained results show that successfully modified waste fly ash can be used as very good TiO2 support.
Change in grip strength in trans people and its association with lean body mass and bone density
Authors: Scharff Miranda , Wiepjes Chantal Maria , Klaver Maartje , Schreiner Thomas , T’Sjoen Guy , den Heijer Martin 
Published: June 2019

Objective
Gender-affirming hormonal treatment (HT) in trans people changes physical appearance. Muscle mass and strength are important aspects of physical appearance, but few data exist on the effect of HT on grip strength and muscle mass. This study aimed to investigate the change in grip strength in trans people during the first year of HT and to study the possible determinants of this change and the associations between changes in grip strength, lean body mass and bone mineral density (BMD).

Design and methods
A multicenter, prospective study was performed, including 249 transwomen and 278 transmen. Grip strength, lean body mass and BMD were measured at baseline and after 1 year.

Results
After 1 year of HT, grip strength decreased with −1.8 kg (95% CI −2.6; −1.0) in transwomen and increased with +6.1 kg (95% CI +5.5; +6.7) in transmen. No differences in grip strength change was found between age groups, BMI groups, hormonal administration routes or hormone concentrations. In transmen, increase in grip strength was associated with increase in lean body mass (per kg increase in grip strength: +0.010 kg, 95% CI +0.003; +0.017), while this was not found in transwomen (per kg increase in grip strength: +0.004 kg, 95% CI −0.000; +0.009). Change in grip strength was not associated with change in BMD in transwomen and transmen.

Conclusions
After 1 year of HT, grip strength decreased in transwomen, and increased in transmen. In transmen only, change in grip strength was associated with change in lean body mass.
Screening of Marine-Derived Fungi Extracts as Antioxidant, Tyrosinase Inhibitor, and Antiglycation
Authors: Nursid Muhamad , Marraskuranto Endar , Septorini Dilaika , Batubara Irmanida 
Published: June 2019

Marine-derived fungi are of great interest as new promising sources of bioactive secondary metabolites. The aim of this study was to determine the antioxidant activity, tyrosinase inhibitor and antiglycation of marine-derrived fungi collected from Kepulauan Seribu Marine National Park, Indonesia. Antioxidant screening was determined using the 1,1-diphenyl-2-picryl hydrazyl (DPPH) method. The tyrosinase inhibitor was screened using L-tyrosine substrate, while the antiglycation test was determined by the ability to inhibit the formation of advanced glycation end products (AGEs). A total of 28 marine fungi isolates had been screened for their activities. Mycelium extract of MFP 271 had the best antioxidant activity with the IC50 of 287.25 ± 50 µg/mL. Mycelium extract of MFP 277 had the best tyrosinase inhibitory activity with the IC50 of 586.42 µg/mL. The MFP 274-broth extract had the highest antiglycation activity with the IC50 value of 298.57 µg/mL. Based on the screening, the crude extracts were considered weak as antioxidant, but tyrosinase inhibitor and antiglycation activity of MFP 277 and MFP 274 are needed to investigate in depth activities.
Artemisia L. Subgen. Drancunculus (Bess.) Rydb. Taksonlarının uçucu yağ kompozisyonları ve antimikrobiyal özellikleri
Authors: KIRBAĞ Sevda , BAĞCI Eyüp , CİVELEK Şemsettin , KURŞAT Murat 
Published: June 2019

Bu çalışmada, Türkiye'nin farklı yerlerinden toplanan ArtemisiaL. cinsinin Drancunculus(Bess.) Rydb. altcinsi taksonlarınınuçucu yağların bileşenleri ve bunların antimikrobiyal özellikleri belirlenmiştir.Uçucu yağlar bitkilerin toprak üstü kısımlarından hidrodistilasyon metodu kullanılarak elde edilmiştir. Antimikrobiyal aktivite oyuk agar metodu kullanılarak tespit edilmiştir.Artemisia campestrisL.var. campestris temel uçucu yağ bileşenleri sırasıyla naftalen (%34.69),b–pinen (%13.29), spatulenol (%7.70), 2,4 hexadien-1-one (%6.99) penta-2,4-dione (%4.96), α -pinen (1.65%), limonen (%1.51) tespit edilmiştir. Artemisia campestris var.marschalliana(Spreng.) Poljak.’dabenzen (%17.34),b–pinen (%10.54), spatulenol (%10.45), 1-phenly-penta-2,4-diyn (%8.06), karyofillen oxid (%6.93), asenaphthylen (6.31%), limonen (4.45%), α-pinen (3.70%), b-mirsen (3.23%)belirlenmiştir. Artemisia campestris L. var. araratica(Novopokr.) Poljak’da b–pinen (%18.32), b–pinen (%8.03), limonen (%5.19), cis-osimen (%2.87), trans-geraniol (1.93), trans-isolimonen (1.86%), kamfor (%1.79) olarak belirlenmiştir. Artemisia scoparia Waldst. &amp; Kit.’da1-phenyl-penta-2,4-diyn (%15.44), benzen (%13.34), b-pinen (%11.85), spatulenol (%11.11), limonen (%6.59), karyofillen oxid (%5.99), α–pinen (%3.73), b-mircen (%3.15), cis-okimen (%2.96) tespit edilmiştir. Artemisiatürlerinin uçucu yağları patojen mikroorganizmaların gelişimlerini farklı oranlarda engellemişlerdir.
A Story of “Rising Voices” and Intercultural Collaboration
Authors: Maldonado Julie , Lazrus Heather 
Published: June 2019

Abstract
Until recently, the voices and wisdom of Indigenous peoples have been largely excluded from climate change science, decision making, and governance. Encouragingly, a shift has emerged in the last few decades. Today, a number of scientists realize the critical importance and value of Indigenous peoples' wisdom, observations, insights, and knowledge. This shift in awareness is visible in initiatives from climate assessments to university- and agency-based projects. Yet, there are few venues devoted to facilitating this work and to creating an intercultural collaborative process based on courage, respect, justice, equality, and reciprocity that addresses our changing climate. Provisioning that missing space is precisely what the Rising Voices: Climate Resilience through Indigenous and Earth Sciences program sets out to do. This is a story about the development of an intercultural network and how the two co-authors—a public and an environmental anthropologist—came to bear witness, to know, and were called to act.
“We Live in the Water”
Authors: Rehak Jana Kopelent 
Published: June 2019

Abstract
Smith Island historical photographs, public and private, in their intimacy and immediacy, encourage us to think about the relationship between appearance and meaning. This article invites us to think through photographs as primary data in anthropological enquiry about the storying of climate in relation to inscribed, visual social biographies in Smith Island albums. I discuss Islanders' intimate visual, ecological, and sensory knowledge in relation to the changing ecology facing Smith Islanders. Old island photos hold memories that interface individuals and their contemporary social identities. When Smith Islanders view their family photographs, they enter the pictorial history of their island. Reading old family photographs with islanders, as they are archived in albums, boxes, or bags, opens a new space for connection of their sense of self with a sense of place.
РАЗРАБОТКА ДИЗАЙНА ГИДРОДИНАМИЧЕСКОГО ИССЛЕДОВАНИЯ В УСЛОВИЯХ КАРБОНАТНОГО КОЛЛЕКТОРА
Authors: Давыдова Анастасия Евгеньевна , Щуренко Александр Александрович , Дадакин Никита Михайлович , Шуталев Артем Дмитриевич , Квеско Бронислав Брониславович 
Published: June 2019

Актуальность исследования обусловлена необходимостью совершенствования методов гидродинамических исследований скважин вследствие неоднозначности интерпретации результатов в условиях карбонатного коллектора. Приоритетами при проведении гидродинамических исследований скважин являются максимальное качество получаемой информации о фильтрационно-емкостных свойствах пластов и минимальные потери добычи нефти в ходе остановки скважин на исследования. С целью выполнения данных задач актуальной является разработка дизайна гидродинамических исследований скважин, предлагаемая в статье. Дизайн позволит обеспечить комплексный подход к моделированию процесса проведения исследований и прогноза получаемых данных. Цель: разработать дизайн гидродинамических исследований скважин с целью оптимизации времени проведения исследований и сокращения периода остановки скважин на этапе опытно-промышленной эксплуатации; подтвердить экономическую эффективность представленной методики. Объекты: скважины Т-23, Т-361, Т-388 месторождения A, продуктивные отложения которого преимущественно представлены кавернозно-трещиноватыми карбонатными породами рифейского возраста. Методы. Поставленные задачи исследования решались теоретически и экспериментально в промысловых условиях. При этом был выполнен анализ публикаций по данной проблеме; проведены промысловые гидродинамические исследования скважин, вскрывающих низкопроницаемый карбонатный коллектор; выполнено моделирование гидродинамических исследований, выполнены сравнительные расчёты по обработке результатов с помощью программного комплекса Saphir компании «KAPPA Engineering». Результаты. Приведены результаты разработки дизайна гидродинамических исследований в условиях карбонатного коллектора. Проанализированы данные гидродинамических исследований для 12 скважин, эксплуатирующих рифейские карбонатные отложения, за период с 2005–2008 гг. представлены результаты по трем скважинам: Т-23, Т-361, Т-388. Представлена методика моделирования гидродинамических исследований в программном комплексе Saphir компании «KAPPA Engineering». Приведен пример расчета времени стабилизации при исследовании скважины методом установившихся отборов, а также оценка оптимального времени регистрации кривой восстановления давления. Также приведено сравнение стандартной методики, которой руководствуются при испытании скважины – РД (руководящий документ) 153-39.0-109-01 «Методические указания по комплексированию и этапность выполнения геофизических, гидродинамических и геохимических исследований нефтяных и нефтегазовых месторождений», с методикой, представленной в статье. На основе данного сравнения была установлена экономическая эффективность.