bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable approach for development of antimicrobial textile material using nanoemulsion for wound care applications
Authors: Gotmare Vijay D. , Kole Sushant S. , Athawale Rajani B. 
Published: May 2018

AbstractDevelopment of nanostructured textile material using sustainable finishing route and to evaluate its performance in the areas like wound management is challenging task. Stable and eco-friendly o/w nanoemulsion of tetrahydroxy curcumin derivative was developed by using high pressure homogenization method. The stable nanoemulsion for the selected drug was developed and evaluated for appearance, particle size distribution (100–300 nm), zeta potential (− 30.1 to − 31.1 mV) and drug content (80–83.3%). Nanoemulsion containing antimicrobial drug were impregnated on the textile material by exhaust methods using β-cyclodextrin and polycarboxylic acid as a crosslinking agent. Treated textile material is evaluated for its antimicrobial activity against standard antimicrobial strip using both AATCC 147 and AATCC 100, treated samples shows positive results against both positive and negative bacteria. Current eco-friendly technique would be innovative step towards development of medical textile for wound care applications.
Comparing Postnatal Development of Gonadal Hormones and Associated Social Behaviors in Rats, Mice, and Humans
Authors: Bell Margaret R 
Published: May 2018

AbstractPostnatal development includes dramatic changes in gonadal hormones and the many social behaviors they help regulate, both in rodents and humans. Parental care-seeking is the most salient social interaction in neonates and infants, play and prosocial behaviors are commonly studied in juveniles, and the development of aggression and sexual behavior begins in peripubertal stages but continues through late adolescence into adulthood. Although parental behaviors are shown after reproductive success in adulthood, alloparenting behaviors are actually high in juveniles as well. These behaviors are sensitive to both early-life organizational effects of gonadal hormones and later-life activational regulation. However, changes in circulating gonadal hormones and the display of the previous behaviors over development differ between rats, mice, and humans. These endpoints are of interest to endocrinologist, toxicologists, and neuroscientists because of their relevance to mental health disorders and their vulnerability to effects of endocrine-disrupting chemical exposure. As such, the goal of this mini-review is to succinctly describe and relate the postnatal development of gonadal hormones and social behaviors to each other, over time, and across animal models. Ideally, this will help identify appropriate animal models and age ranges for continued study of both normative development and in contexts of environmental disruption.
Reversing Course on Obamacare: Why Not Another Medicare Catastrophic?
Authors: Peterson Mark A. 
Published: May 2018

AbstractNearly three decades before the Affordable Care Act (ACA) was put on the precipice of repeal by the 2016 election of a unified Republican government, the Medicare Catastrophic Coverage Act (MCCA) was enacted with fanfare by one Congress and dismantled by the next. As the one social program terminated by Congress—also involving health care coverage expansions for millions of beneficiaries and imposing costs on identifiable constituencies—the MCCA experience could provide insights into the politics that define the fate of the ACA. This article compares and contrasts the two episodes, focusing on the political-institutional contexts of each case, the processes that produced the shifting coalitions from enactment to repeal, and the policy attributes that posed risks or provided protection to each program. The political-institutional contexts and the processes of coalition change could hardly have been more different for MCCA and ACA. However, they had some shared vulnerabilities stemming from program design. The ACA survived the political weakness inherent in its policy attributes due to its particular balance and timing of benefits and costs and by being shielded long enough by election results and the constitutional separation of powers to have its benefits take root.
The developmental origin of brain tumours: a cellular and molecular framework
Authors: Azzarelli Roberta , Simons Benjamin D. , Philpott Anna 
Published: May 2018

ABSTRACT
The development of the nervous system relies on the coordinated regulation of stem cell self-renewal and differentiation. The discovery that brain tumours contain a subpopulation of cells with stem/progenitor characteristics that are capable of sustaining tumour growth has emphasized the importance of understanding the cellular dynamics and the molecular pathways regulating neural stem cell behaviour. By focusing on recent work on glioma and medulloblastoma, we review how lineage tracing contributed to dissecting the embryonic origin of brain tumours and how lineage-specific mechanisms that regulate stem cell behaviour in the embryo may be subverted in cancer to achieve uncontrolled proliferation and suppression of differentiation.
Static and Dynamic Structures of Perovskite Halides ABX3 (B = Pb, Sn) and Their Characteristic Semiconducting Properties by a Hückel Analytical Calculation
Authors: Yamada Koji , Hino Satomi , Hirose Satoshi , Yamane Yohei , Turkevych Ivan , Urano Toshiyuki , Tomiyasu Hiroshi , Yamagishi Hideo , Aramaki Shinji 
Published: May 2018

Abstract
Solid solutions of methylammonium lead iodide (CH3NH3PbI3, abbreviated as MAPbI3) and formamidinium lead iodide (CH(NH2)2PbI3, as FAPbI3), which have been expected to be suitable materials as a visible light absorber of solar cells, were characterized by differential thermal analysis (DTA), XRD, 1H, 207Pb NMR and 127I nuclear quadrupole resonance (NQR). Continuous solid solutions of MAPbI3 and FAPbI3 were confirmed to have a cubic perovskite structure at 298 K except the tetragonal MAPbI3.127I NQR spectra as well as DTA for CH3NH3PbI3 showed successive phase transitions at 162 K and 333 K associated with the space group transformation from Pnma, I4/mcm to Pm$\bar{3}$m. FAPbI3 (Black phase) showed similar successive phase transitions at around 120–140 K and 283 K. The motional narrowing phenomenon observed on the 207Pb NMR proved useful to evaluate the halide ion migration and the activation energies were estimated to be ca. 48 kJ/mol for APbBr3 (A = Cs and CH3NH3), while the narrowing phenomena could not be observed clearly for MAPbI3 below 500 K, suggesting a lower concentration of vacancies than bromide analogs. Finally, Hückel calculations were performed for ABX3 (B = Sn, Pb) to demonstrate their excellent performance as a visible light absorber of solar cells, i.e., the direct band gap transition with a tunable property and the small effective masses of electron and hole.
Protonated Bis-1,2,3-triazole as an Anion-Binding Chiral Brønsted Acid for Catalytic Asymmetric Friedel–Crafts Reaction of Indoles with Imines
Authors: Furukawa Yukino , Suzuki Ryuhei , Nakashima Tsubasa , Gramage-Doria Rafael , Ohmatsu Kohsuke , Ooi Takashi 
Published: May 2018

Abstract
The complex of chiral C2-symmetric bis-1,2,3-triazole and an achiral Brønsted acid is introduced as a new class of chiral acid catalysts. The catalytic activity and stereocontrolling ability of this chiral Brønsted acid can be tuned simply by changing the achiral acid. The synthetic relevance of this salient feature is demonstrated in the asymmetric Friedel–Crafts reaction of indoles with N-sulfonyl imines.
Physiologically-based pharmacokinetic modelling of infant exposure to efavirenz through breastfeeding
Authors: Olagunju Adeniyi , Rajoli Rajith K. R. , Atoyebi Shakir A. , Khoo Saye , Owen Andrew , Siccardi Marco 
Published: May 2018

Background: Very little is known about the level of infant exposure to many drugs commonly used during breastfeeding. The aim of this study was to develop a physiologically-based pharmacokinetic (PBPK) model for predicting infant exposure to maternal efavirenz through breastmilk. Methods: A breastfeeding PBPK model combining whole-body maternal and infant sub-models was constructed from drug-specific and system parameters affecting drug disposition using mathematical descriptions. The model was validated against published data on the pharmacokinetics of efavirenz in nursing mother-infant pairs. Further simulations were conducted to assess exposure in the context of the 400 mg reduced dose of efavirenz as well as best- and worse-case scenarios. Results: The model adequately described efavirenz pharmacokinetics, with over 80% of observed data points (203 matched breast milk and plasma pairs) within the predictive interval. All parameters were within 2-fold difference of clinical data. Median (range) predicted versus observed breast milk AUC0-24, Cmax and Cmin at the standard 600 mg dose were 75.0 (18.5-324) versus 68.5 (26.3-257) µg.hr/mL, 4.56 (1.17-16.0) versus 5.39 (1.43-18.4) µg/mL, and 2.11 (0.38-12.3) versus 1.68 (0.316-9.57) µg/mL, respectively. Predicted plasma AUC0-24, Cmax and Cmin at 400 mg reduced dose were similar to clinical data from non-breastfeeding adults. Model-predicted infant plasma concentrations were similar to clinical data, 0.15 (0.026–0.78) μg/mL at the 400 mg maternal dose in pooled analysis, approximately 25% lower than simulated exposure at 600 mg. The maximum exposure index was observed in the youngest infants, 5.9% (2.2-20) at 400 mg and 8.7% (3.2-29) at 600 mg. Thirteen and 36% of 10 days-1 month old infants were predicted to have exposure index above the 10% recommended threshold at 400 mg and 600 mg maternal dose, respectively. Conclusions: This application of PBPK modelling opens up opportunities for expanding our understanding of infant exposure to maternal drugs through breastfeeding.
Simulation and visualization of multiple KEGG pathways using BioNSi
Authors: Yeheskel Adva , Reiter Adam , Pasmanik-Chor Metsada , Rubinstein Amir 
Published: May 2018

Motivation: Many biologists are discouraged from using network simulation tools because these require manual, often tedious network construction. This situation calls for building new tools or extending existing ones with the ability to import biological pathways previously deposited in databases and analyze them, in order to produce novel biological insights at the pathway level. Results: We have extended a network simulation tool (BioNSi), which now allows merging of multiple pathways from the KEGG pathway database into a single, coherent network, and visualizing its properties. Furthermore, the enhanced tool enables loading experimental expression data into the network and simulating its dynamics under various biological conditions or perturbations. As a proof of concept, we tested two sets of published experimental data, one related to inflammatory bowel disease condition and the other to breast cancer treatment. We predict some of the major observations obtained following these laboratory experiments, and provide new insights that may shed additional light on these results. Tool requirements: Cytoscape 3.x, JAVA 8 Availability: The tool is freely available at http://bionsi.wix.com/bionsi, where a complete user guide and a step-by-step manual can also be found.
Birds of primary and secondary forest and shrub habitats in the peat swamp of Berbak National Park, Sumatra
Authors: Darras Kevin , Rahman Dedi , Sugito Waluyo , Mulyani Yeni , Prawiradilaga Dewi , Rozali Agus , Fitriawan Irfan , Tscharntke Teja 
Published: May 2018

Background: Tropical lowland rainforests are threatened by deforestation and degradation worldwide. Relatively little research has investigated the degradation of the forests of South-east Asia and its impact on biodiversity, and even less research has focused on the important peat swamp forests of Indonesia, which experienced major losses through severe fires in 2015. Methods: We acoustically sampled the avifauna of the Berbak National Park in 2013 in 12 plots split in three habitats: primary swamp forest, secondary swamp forest, and shrub swamp, respectively representing non-degraded, previously selectively logged, and burned habitats. We analysed the species richness, abundance, vocalisation activity, and community composition across acoustic counts, plots, feeding guilds and IUCN Red List categories. We also analysed community-weighted means of body mass, wing length, and distribution area. Results: The avifauna in the three habitats was remarkably similar in richness, abundance and vocalisation activity, and communities mainly differed due to a lower prevalence of understory insectivores (Old-World Babblers, Timaliidae) in shrub swamp. However primary forest retained twice as many conservation-worthy species as shrub swamp, which harboured heavier, probably more mobile species, with larger distributions than those of forest habitats. Conclusions: The National Park overall harboured higher bird abundances than nearby lowland rainforests. Protecting the remaining peat swamp forest in this little-known National Park should be a high conservation priority in the light of the current threats coming from wildlife trade, illegal logging, land use conversion, and man-made fires.
Status of drowning in Nepal: A study of central police data
Authors: Sedain Bhagabati , Pant Puspa Raj 
Published: May 2018

Background: Drowning is a serious and mostly preventable injury-related cause of death. Low-and-middle income countries represent 90% of total drowning deaths worldwide. There is lack of epidemiological studies of drowning in Nepal. The aim of this paper is to describe the status of drowning in Nepal. Methods: Cases of drowning, occurring between January 2013 and December 2015 were extracted from the Daily Incident Recording System of Nepal Police. Variables on age, sex of the deceased, types of water bodies, places, season when drowning occurred and activities of deceased were extracted and descriptive analysis was done. Results: A total of 1,507 drowning cases were recorded over a 3 year period. The rate of drowning was 1.9 per 100,000 (2.95 for males and 0.92 for females). Majority of drowning occurred among males (76%) and more than half were (53%) under 20 years of age. Mostly drowning occurred in rivers (natural water bodies). The findings provide strong indication that drowning occurs throughout the year in Nepal. Children were highly vulnerable to drowning. The magnitude of drowning was found to be lower than estimated by global burden of disease (GBD) study. Conclusion: The burden of drowning in Nepal is considerable, but mostly unknown to the public. Despite only having access to a limited data source, this study provides useful evidence that comprehensive research in Nepal is needed urgently.
Promoting men’s awareness, self-examination, and help-seeking for testicular disorders: a systematic review of interventions
Authors: Saab Mohamad M. , Davoren Martin P. , Murphy Aileen , Murphy David , Cooke Eoghan , Landers Margaret , Fitzgerald Serena , Richardson Noel , Rovito Michael J. , Von Wagner Christian , Murphy Mike , Dahly Darren , Hegarty Josephine 
Published: May 2018

Background: Testicular cancer (TC) is commonly diagnosed among men aged 15-40 years. The incidence of TC is on the rise. Benign testicular disorders such as testicular torsion and epididymitis can lead to testicular ischemia, sepsis, and infertility if left untreated. This systematic review aims to evaluate the effectiveness of studies promoting men’s knowledge and awareness of testicular disorders and/or self-examination, behaviours and/or intentions to examine their testes, and help-seeking behaviours and/or intentions for testicular symptoms. Methods: Academic Search Complete, Medline, CINAHL, PsychINFO, ERIC, the Cochrane Library, the World Health Organisation International Clinical Trials Registry Platform, Clinicaltrials.gov, Grey Literature Report, and Open Grey were searched for studies published between November 2014 and April 2018. The methodological quality and level of evidence per outcome were assessed. Results: There were five papers included: two were experimental studies, two were systematic reviews, and one was an integrative review. The majority of the reviewed interventions were successful in increasing men’s awareness of TC and self-examination. Examples include a television show featuring a celebrity with TC, a university campaign, and interactive educational sessions. The impact of the reviewed interventions on health beliefs (i.e. perceived susceptibility, severity, benefits, barriers, and self-efficacy) varied across the reviewed literature. Studies promoting help-seeking for testicular symptoms and awareness of benign testicular disorders were lacking. Conclusions: This review highlights the importance of evaluating educational interventions aimed at younger men, whilst raising their awareness of testicular disorders and increasing their help-seeking intentions for testicular symptoms. Given the lack of consensus around scheduled testicular self-examination among younger men, clinicians are encouraged to instruct men to familiarise themselves with the look and feel of their own testes and to seek timely medical attention for abnormalities. Registration: The review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) under the registration number CRD42018093671.
Consumer Subsidies with a Strategic Supplier: Commitment vs. Flexibility
Authors: Chemama Jonathan , Cohen Maxime C. , Lobel Ruben , Perakis Georgia 
Published: May 2018

Governments use consumer incentives to promote green technologies (e.g., solar panels and electric vehicles). Our goal in this paper is to study how policy adjustments over time will interact with production decisions from the industry. We model the interaction between a government and an industry player in a two-period game setting under uncertain demand. We show how the timing of decisions affects the risk sharing between the government and the supplier, ultimately affecting the cost of the subsidy program. In particular, we show that when the government commits to a fixed policy, it encourages the supplier to produce more at the beginning of the horizon. Consequently, a flexible subsidy policy is on average more expensive, unless there is a significant negative demand correlation across time periods. However, we show that the variance of the total sales is lower in the flexible setting, implying that the government’s additional spending reduces the adoption level uncertainty. In addition, we show that for flexible policies, the supplier is better off in terms of expected profits, whereas the consumers can either benefit or not depending on the price elasticity of demand. Finally, we test our insights with a numerical example calibrated on data from a solar subsidy program.This paper was accepted by Gad Allon, operations management.
Option Prices in a Model with Stochastic Disaster Risk
Authors: Seo Sang Byung , Wachter Jessica A. 
Published: May 2018

Contrary to well-known asset pricing models, volatilities implied by equity index options exceed realized stock market volatility and exhibit a pattern known as the volatility skew. We explain both facts using a model that can also account for the mean and volatility of equity returns. Our model assumes a small risk of economic disaster that is calibrated based on international data on large consumption declines. We allow the disaster probability to be stochastic, which turns out to be crucial to the model’s ability both to match equity volatility and to reconcile option prices with macroeconomic data on disasters. This paper was accepted by Lauren Cohen, finance.
Reviews
Authors: Drábek Pavel , Raw Laurence 
Published: May 2018

Abstract
Adapting Translation for the Stage, Geraldine Brodie and Emma Cole (eds) (2017) London and New York: Routledge. 298 pp., ISBN: 9781138218871, h/bk, £110.00; ISBN: 9781315436814, e/bk, £35.99
The Translator on Stage, Geraldine Brodie (2018) New York: Bloomsbury. 208 pp., ISBN: 9781501322112, h/bk, £96.00; ISBN: 9781501322105, p/bk, £23.99; ISBN: 9781501322136, e/bk, £25.99
Writing for Radio, Christopher William Hill (2015) London: Bloomsbury, 163 pp., ISBN: 978-1-408-13983-7, p/bk, £16.99
Slow burn: James M. Cain, slow cinema and György Fehér’s Szenvedély
Authors: Hodgkins John 
Published: May 2018

Abstract
Few novels have proven as alluring to filmmakers as James M. Cain’s The Postman Always Rings Twice, which since its publication in 1934 has been adapted to the screen seven times in six different countries. This article focuses on one such adaptation – a film that has to date received little critical attention: György Fehér’s Szenvedély (or Passion) from 1998. More precisely, it positions Szenvedély as a work of ‘slow cinema’, arguing that Fehér’s film draws heavily on the aesthetic practices of this emergent genre in its creative engagement with Cain’s story of lust and murder, its engagement with the affective economy generated by Cain’s text, and the intensities this fosters. With an emphasis on affect and lived time over narrative momentum and causality, Szenvedély’s affords viewers a temporally engrossing, viscerally arresting cinematic experience that – in its own distinctive, insinuative manner – is downright Cainsian in its power to move and shock.
Cultural continuity and national emasculation: Werner Herzog’s and Dariush Mehrjui’s cinematic adaptations of Georg Büchner’s Woyzeck
Authors: Kopp Daniel 
Published: May 2018

Abstract
Taking the example of German dramatist Georg Büchner’s play Woyzeck, this article presents several arguments to differentiate an influential discourse on film adaptations: the discourse of fidelity – the idea that adaptations are evaluated by their close translation of an original work of literature to the cinematic screen. After having criticized this discourse in terms of the textual and editorial status of Büchner’s drama, the article provides a comparative case study contrasting two adaptations of Georg Büchner’s Woyzeck to differentiate the issue: Werner Herzog’s approach Woyzeck (1979) and Dariush Mehrjui’s transcultural adaptation Postchi (Postman) (1972). While Herzog’s film is often considered a faithful adaption, it not only provides interesting transformations of Büchner’s drama but, as will be argued, Herzog chose his specific, theatricalized approach to make the film relevant to German audiences of the 1970s by recreating a lost connection to Germany’s cultural heritage. The supposed faithfulness of his adaptation has to be considered in this specific context. Mehrjui’s transcultural adaptation, in contrast, transposes Büchner’s Woyzeck to an Iranian context, making it relevant for specific historical and societal issues in Iran in the 1970s. Büchner’s Woyzeck, in which the theme of the eponymous character’s impotence plays an important role, becomes an allegorical story of national emasculation in Mehrjui’s adaptation. As different as Herzog’s and Mehrjui’s cinematic approaches and intentions may be – creating national cultural continuity versus creating a story of national emasculation – they both develop highly creative adaptations of Büchner’s Woyzeck.
Translatorial and editorial paratexts in the twentieth-century Polish Hamlets
Authors: Romanowska Agnieszka 
Published: May 2018

Abstract
Translatorial and editorial paratexts found in the twentieth-century Polish editions of Hamlet reveal a variety of socio-political and historico-literary contexts vital for the play’s reception and explaining its crucial position in the canon of Shakespearean translations. The article presents an analysis of introductions, prefaces, afterwords, notes, essays, commentaries and footnotes or endnotes that accompany the published versions authored by various translators between 1913 and 1997 and discusses the diversity of their content and functions with the aim of establishing a range of aspects that have been shaping the reception of this play in Poland.