bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discourse as the object of philosophical and linguistics studies
Authors: Marcelli Miroslav 
Published: September 2018

Abstract
The article deals with the ways philosophers and linguists reflect the topic of discourse. In the first part, the conception of the discourse as the theoretical construct is characterized. The next parts are devoted to discourse analyses as they were developed by linguists, semioticians and philosophers in the sixties and seventies. The works of Emil Benveniste, Roland Barthes and Michel Foucault are put in the foreground. As for Foucault’s archeological method, this attempt to find rules of the autonomous discourse led to an impasse. The last part of the article draws the research line of the critical discourse analysis and shows its philosophical inspirations.
Communicative and pragmatic premises of the Slovak interactional stylistics
Authors: Orgoňová Oľga 
Published: September 2018

Abstract
The study deals with interactional stylistics viewed as a discipline based on its own pragmatic potential (while consideration has been given to addressee and to speech comprehensibility and clarity even earlier). This pragmatic potential in its developed form represents, in the context of contemporary methodology of humanities, a contribution to restructuration of stylistics. The discipline, viewed from this point, receives a new function: to observe and interpretationally explain, firstly, the meaning of interactions between agents in the observed communication acts and, secondly, the effect that this interaction brings. In the centre of interactional stylistics is the human (anthropocentrism), who through his communication acts negotiates about the contents of interactions, regarding own interests, as well as cultural, social and historical conventions. The meaning of used expressions and the overall sense of such interactions thus emerge in the context of communicational events, based on the communication subjects’ coping with surrounding reality through assimilation and accommodation.
The Consignment of Indonesian Migrant Workers in Saudi Arabia and Its Resilience: Examining the Impacts of Indonesia’s Moratorium Policy (2011-2015).
Authors: Elvianti Witri , Sidik Jihan Djafar 
Published: September 2018

Although Indonesian migrant workers in Saudi Arabia, particularly at informal sectors, have exponentially increased in last decades, most of the time, they have also faced several constraints such as the lack of protection that supposedly addressed by the Government of Indonesia (GoI) through Indonesian embassy, limited numbers of regulations that could protect the Indonesian migrant workers from the Government of Saudi Arabia, due to the absence of Memorandum of Understanding between the two countries. Such complex circumstances made the position of Indonesian migrant workers worsened due to their disability in gaining their rights. In the implementation process, the GoI’s protection has not been maximal in ensuring the safety of their workers abroad. The situation reached the peak when the death penalty for Ruyati binti Satubi was conducted by Government of Saudi Arabia without any initiatives informing Indonesian authority prior to the execution. Consequently the former President of Indonesia, Susilo Bambang Yudhoyono, declared a moratorium policy during the cabinet meeting on June 23, 2011, in order to improve the protection mechanism of Indonesian migrant domestic workers. In milieu of this issue, the researchers attempted at analyzing the impacts of such a policy. The analysis was based on national interest theory. In the context of Indonesian migrant domestic workers, this study came to argue that the moratorium policy could be seen as a manifestation of political commitment from Indonesia’s government perceiving the protection of Indonesian migrant workers is high in the list.
L'évolution de la conception structurelle et proportionnelle des églises orthodoxes du Koura
Authors: KAHWAGI-JANHO HANY 
Published: September 2018

Les systemes de couvrement dans les eglises libanaises construites entre les XIII' et XIX' siec1es adoptaient deux solutions principales : Ie couvrement avec une voute en berceau auquel est associe Ie systeme structural base sur les murs porteurs, et Ie couvrement avec des voutes d'aretes auquel est associe Ie procede structural base sur des piliers. Certains monuments proposaient par ailleurs des solutions mixtes en joignant les deux principes.
L'usage de la voute en berceau semble avoir ete Ie plus repandu au cours du Moyen Age, tandis que celui de la voute II aretes seraitdevenu de plus en plus courant aux epoques tardives. Utilise dans certaines des eglises de I' epoque mamelouke et dans d'autres des XVI' et XVII' siec1es, ce demier est presque systematiquement privilegie dans les eglises des XVIII' et XIX' siecles, tel que Ie constate L. Nordiguian (1985 : 69). II marque en tout cas un progres dans la comprehension de la logique structurale de la pierre et du principe de la descente des charges. Celle-ci se fait Ie long des murs lateraux dans Ie systeme des voOtes en berceau, ce qui induit, d' une part, un epaississement des murs qui les supportent et donc un cout economique consequent, et, d'autre part, un assombrissement de l'interieur des monuments dO au nombre limite d'ouvertures qu'il est possible de pratiquer dans ce genre de structure.
TRADITIONS AND INNOVATIONS IN CHINESE «BIRD-AND-FLOWER» PAINTING FROM THE SECOND HALF OF THE 20TH CENTURY TO THE BEGINNING OF THE 21ST CENTURY IN HE SHUIFA’S CREATIVE WORK
Authors: Biyun Zhang 
Published: September 2018

The purpose of the work. The research is devoted to the study of the features of He Shuifa’s creative work and its influence on the development of Chinese traditional «bird-and-flower» painting from the second half of the 20th century to the beginning of the 21st century. The research methodology consisted in revealing the features of He Shuifa’s style through comparing his works with the works by other masters of «bird-and-flower» painting (taking into account the coloristic, stylistic and subject features), and by analyzing his works representing different time periods. The scientific novelty of the work lies in the deepened understanding of He Shuifa’s influence on the development of Chinese painting in the context of China’s cultural progress, socio-political changes in the state and the globalization of the modern world. The features of He Shuifa’s creative work of different periods were revealed. In his early works (from the early 1970’s), the artist used the «Gunbi» style and the «Sei» style. His favorite motive was the peony. In the late 1970’s the author started his experiments on mixing black ink and paints. In the 1980’s he explored different methods of mixing ink with paint, experimented with color and tone, improving his techniques of applying strokes and lines. At the beginning of the 1990’s there was a new approach to organizing the design – the painter focused on painting plants and birds only. The main characteristic of his artworks of the 2000’s was slightly blurry images. The features of He Shuifa’s modern creative work are «light» painting techniques, frequent small strokes, applying a dry contour or using a wet brush, as well as using moistened paper with liquid link on it. The thematic novelty of the painter’s works is images of mountain flowers, unusual plants and berries. Conclusions. It was proved that the art of «bird-and-flower» painting harmoniously synthesizes the traditions and individuality of the artist, leaving a great deal of space for experiments, making this area interesting for contemporaries. Global interest to He Shuifa’s artworks promotes the popularity of Chinese art and facilitates intercultural dialogue. At the same time, it proves the significance of He Shuifa’s role in the development of the «bird-and-flower» genre, which occurred to a large extent against the backdrop of socio-political tension and totalitarian regime.
Targeting newly identified ERβ/TGF‐β1/SMAD3 signals with the FDA‐approved anti‐estrogen Faslodex or an ERβ selective antagonist in renal cell carcinoma
Authors: Song Wenbin , He Dalin , Chen Yule , Yeh Chiuan‐Ren , Hsu Iawen , Huang Qingbo , Zhang Xu , Chang Luke Sien‐Shih , Zuo Li , Chen Jiasheng , Doersch Karen M. , Chang Chawnshang , Li Lei , Yeh Shuyuan 
Published: September 2018

Renal cell carcinoma (RCC) has the third highest mortality rate among urological tumors, and 20–30% of RCC patients present with metastatic RCC at the time of diagnosis. Although recent studies have indicated that estrogen receptor β (ERβ) could play promoting roles in RCC progression, the detailed mechanisms remain to be clarified. In the present study, we found that expression of ERβ, but not ERα, increases with tumor stage and grade, and also observed that modification of ERβ signals using estrogens/anti‐estrogens, shRNA knockdown of ERβ and overexpression of ERβ using ectopic cDNA affects RCC cell proliferation, migration and invasion. Mechanism analysis revealed that ERβ can promote RCC cell invasion via an increase in transforming growth factor β1 (TGF‐β1)/SMAD3 signals, and interrupting TGF‐β1/SMAD3 signals with a TGFβR1 inhibitor can reverse/block ERβ‐increased RCC cell migration. Importantly, preclinical analyses using in vivo mouse models of RCC revealed that targeting of this newly identified ERβ/TGF‐β1/SMAD3 pathway with either the FDA‐approved anti‐estrogen ICI182,780 (Faslodex) or a selective ERβ antagonist 4‐[2‐phenyl‐5,7 bis(trifluoromethyl)pyrazolo[1,5‐a]pyrimidin‐3‐yl]phenol can significantly reduce RCC tumor growth and invasion, which may be suitable as the basis for novel therapies to more effectively suppress metastatic RCC.
Trends in the Prevalence and Incidence of Psoriasis and Psoriatic Arthritis in Ontario, Canada: A Population‐Based Study
Authors: Eder Lihi , Widdifield Jessica , Rosen Cheryl F. , Cook Richard , Lee Ker‐Ai , Alhusayen Raed , Paterson Michael J. , Cheng Stephanie Y. , Jabbari Shirin , Campbell Willemina , Bernatsky Sasha , Gladman Dafna D. , Tu Karen 
Published: September 2018

ObjectiveTo estimate the prevalence and incidence of psoriasis and psoriatic arthritis (PsA) over time in Ontario, Canada.MethodsWe performed a population‐based study of Ontario health administrative data, using validated case definitions for psoriasis and PsA. We computed the crude and age‐ and sex‐standardized cumulative prevalence and incidence of psoriasis from 2000 to 2015.ResultsAmong the 10,774,802 individuals ages ≥20 years residing in Ontario in 2015, we identified 273,238 patients with psoriasis and 18,655 patients with PsA, equating to cumulative prevalence estimates of 2.54% and 0.17%, respectively. Correcting the prevalence estimates for imperfect sensitivity and specificity resulted in similar estimates. The male:female ratio was approximately 1.0 for both conditions. For psoriasis, the age‐ and sex‐standardized cumulative prevalence increased from 1.74% in 2000 to 2.32% in 2015. For PsA, the age‐ and sex‐standardized cumulative prevalence increased from 0.09% in 2008 to 0.15% in 2015. Between 2008 and 2015, annual incidence rates for psoriasis decreased, whereas those for PsA remained relatively stable.ConclusionThe prevalence and incidence of psoriasis and PsA in Ontario are similar to those observed in Europe and the US. The steady increase in the prevalence of psoriasis and PsA over the past decade may be due to a combination of population aging, population growth, and increasing life expectancy.
Development of thermoplastic films for ultrasonic manufacturing of printed circuit boards
Authors: Hopmann Christian , Höfs Christopher , Schomburg Werner Karl , Kosloh Julia , Sackmann Johannes 
Published: September 2018

AbstractConventional production processes of PCB involve a high amount of complex production steps and the use of hazardous chemicals. Furthermore, a great effort is required for their recycling. Ultrasonic hot embossing of coextruded films, filled with electrical conductive fillers, could be an economic and ecological alternative for the production of PCB. This study focuses on the identification of suitable filler–matrix combinations for the isotropic and anisotropic conductive film layers. Hence, monolayer films with different fillers and filler contents are extruded. Conductivities of 8.31 and 12 S/m were measured in cross and machine direction, respectively, for a polypropylene‐film with 10 wt.‐% of CNT. This is two magnitudes below the required 535 S/m. With 70 mS/m, the conductivity in thickness direction is 115–170 times lower. This is caused by process‐related surface layers with low filler content. For steel fibers, no electrical conductivity can be measured.
Iridium‐Catalyzed α‐Selective Arylation of Styrenes by Dual C−H Functionalization
Authors: Cooper Phillippa , Crisenza Giacomo E. M. , Feron Lyman J. , Bower John F. 
Published: September 2018

AbstractAn IrI‐system modified with a ferrocene derived bisphosphine ligand promotes α‐selective arylation of styrenes by dual C−H functionalization. These studies offer a regioisomeric alternative to the Pd‐catalyzed Fujiwara–Moritani reaction.
Micropatterned Ultrathin MOF Membranes with Enhanced Molecular Sieving Property
Authors: Huang Kang , Wang Bo , Guo Song , Li Kang 
Published: September 2018

AbstractMetal–organic frameworks (MOFs) are attractive crystalline materials for membranes due to their diverse crystalline pore structures and molecular separation properties. However, the fabrication cost is relatively high compared to conventional polymeric membranes. The concern of the cost could be eased if they are part of a value‐added device, for example, as the key separation unit in a lab‐on‐a‐chip device. This study demonstrates the feasibility of miniaturization of MOF membranes by patterning the membrane surface, a necessary step for MOF membranes to be used in compact devices. Water‐stable ultrathin UiO‐66 membranes with a thickness down to 250 nm on a substrate with a complex pattern were grown. The patterned membranes showed a 100 % improvement in the apparent permeation flux over conventional flat‐UiO‐66 membranes without compromising the molecular separation property, indicating the complexity of a surface would not be a formidable obstacle to the MOF membrane fabrication.
A new frontier in digital activism: An exploration of digital feminism in Fiji
Authors: Brimacombe Tait , Kant Romitesh , Finau Glenn , Tarai Jope , Titifanue Jason 
Published: September 2018

AbstractSocial media has become a crucial feature of the Pacific islands in the 21st century, providing people with the means to demand greater accountability and transparency and offering an alternative platform through which to engage in policy processes, dialogue, and debate. Increasing social media access and use has altered the existing media and communications landscape, with implications for mainstream media reporting, censorship, and citizen voice. This paper explores this phenomenon through an examination of the digital activism practices of a group of women's rights activists in Fiji. In doing so, this paper explores how social media is being used as an online platform for information dissemination and debate, as well as the implications this is having “offline” as part of efforts to influence policymaking.
The Complex Interdependence of China's Belt and Road Initiative in the Philippines
Authors: Rabena Aaron Jed 
Published: September 2018

AbstractComplex interdependence refers to the multiple channels of interaction and agenda in interstate relations, which involve domestic (public and private) stakeholders and nonmilitary issues. Since the Belt and Road Initiative (BRI) came into being, most analyses have largely focused on infrastructure development. The BRI not only has the potential to impact a host government's socioeconomic agenda but also its overall bilateral relationship with China. It is therefore imperative to measure the progress and prospects of China's Belt and Road projects in the Philippines, in line with Beijing's strategic goal to deepen complex interdependence with partner‐states, against the BRI's five major dimensions of cooperation: (a) policy coordination, (b) infrastructure development and connectivity, (c) trade and investment facilitation, (d) financial coordination and integration, and (e) people‐to‐people ties and connectivity. These, together with the examination of China's BRI projects in other Asian countries as modes of comparison, are crucial in assessing probable outcomes in the Philippines. The paper includes policy recommendations based on possible pitfalls and risks that may hamper the advancement of the Belt and Road projects in the Philippines and Sino‐Philippine bilateral interaction.
CYP3A but not P‐gp plays a relevant role in the in vivo intestinal and hepatic clearance of the delta‐specific phosphoinositide‐3 kinase inhibitor leniolisib
Authors: De Buck Stefan , Kucher Klaus , Hara Hisanori , Gray Cathy , Woessner Ralph 
Published: September 2018

AbstractThis study investigated the effect of itraconazole, a strong dual inhibitor of cytochrome P450 (CYP) 3A4 and P‐glycoprotein (P‐gp), on the single dose pharmacokinetics of leniolisib. In order to differentiate the specific contribution of CYP3A from P‐gp, the potential interaction with quinidine, a strong inhibitor of P‐gp but not CYP3A, was studied as well. Using a fixed‐sequence, 3‐way crossover design, 20 healthy male subjects received single oral doses of 10 mg leniolisib during three phases separated by a washout: (1) leniolisib alone, (2) 200 mg itraconazole once daily for 9 days plus leniolisib on day 5, and (3) 300 mg quinidine administered 1 h before and 3 h after leniolisib. Itraconazole increased the leniolisib oral drug exposure (AUCinf) by on average 2.1‐fold, whereas the peak drug concentration (Cmax) was less impacted (1.25‐fold). The terminal elimination half‐life (T1/2) of leniolisib was also increased by ~2‐fold. Neither oral AUCinf nor Cmax or T1/2 was found to be altered by quinidine. These findings suggest that the interaction with itraconazole occurred mainly systemically through inhibition of CYP3A, and corroborate our in vitro findings that leniolisib is neither a sensitive CYP3A substrate nor a relevant in vivo substrate for intestinal or hepatic P‐gp. Assuming itraconazole levels achieved complete inhibition of CYP3A, the fractional contribution of CYP3A to the overall disposition of leniolisib is estimated to be about 50%. The concomitant use of leniolisib with strong inhibitors of CYP3A as well as strong and moderate inducers of CYP3A is best avoided.
Synthesis and assembly of human vault particles in yeast
Authors: Wang Meng , Kickhoefer Valerie A. , Rome Leonard H. , Foellmer Oliver K. , Mahendra Shaily 
Published: September 2018

AbstractVault particles are the largest naturally occurring ribonucleoprotein complexes found in the cytoplasm. In all 78 copies of major vault protein (MVP) assemble on polyribosome templates, forming recombinant vault particles, which are of great interest as encapsulation carriers for therapeutics delivery and enzyme stabilization. Baculovirus‐insect cell expression is the only system that has been developed for recombinant vault synthesis, but it has low scalability and slow production rate. In this study, we demonstrated the first use of yeast cells for the production of vault particles with full integrity and functionality solely by expressing the complementary DNA (cDNA) encoding MVP. Vaults synthesized in Pichia pastoris yeast cells are morphologically indistinguishable from recombinant vault particles produced in insect cells, and are able to package and stabilize enzymes resulting in improved longevity and catalytic efficiency. Thus, our results imply that the yeast system is an economical alternative to insect cells for the production of recombinant vaults. The consistency of vault morphology between yeast and insect cell systems also underlines that polyribosome templating may be conserved among eukaryotes, which promises the synthesis and assembly of recombinant human vault particles in other eukaryotic organisms.
Model‐based identification of cell‐cycle‐dependent metabolism and putative autocrine effects in antibody producing CHO cell culture
Authors: Möller Johannes , Korte Katrin , Pörtner Ralf , Zeng An‐Ping , Jandt Uwe 
Published: September 2018

AbstractThe understanding of cell‐cycle‐dependent population heterogeneities in mammalian cell culture and their influence on production rates is still limited. Furthermore, metabolic regulations arising from self‐expressed signaling factors (autocrine/autoinhibitory factors) have been postulated in the past, but no determination of such effects have been made so far for fast‐growing production Chinese hamster ovary (CHO) cells in chemically defined media. In this study, a novel approach combining near‐physiological treatment of cells (including synchronization), population resolved mechanistic modeling and statistical analysis was developed to identify population inhomogeneities. Cell‐cycle‐dependent population dynamics and metabolic regulations due to a putative autocrine factor were examined and their impact on the metabolic rates and antibody production of near‐physiologically synchronized CHO DP‐12 cell cultures was determined. To achieve this, a population resolved model was extended to describe putative autocrine‐dependentt and cell‐cycle‐related metabolic rates for glucose, glutamine, lactate, ammonia, and antibody production. The model parameters were estimated based on data of two repeated batch cultivations (three batches each), with main substrates in excess and potentially inhibiting waste products (lactate and ammonium) controlled within narrow ranges. Significant changes, due to a putative autocrine factor, were identified for lactate and ammonia formation and antibody production. The cell growth and the uptake of glucose and glutamine were only partially affected by the putative autocrine under the given conditions. The results indicate the presence of a self‐expressed autocrine factor and its strong impact on the metabolism of CHO DP‐12 cells. Furthermore, glucose and glutamine uptake, as well as the formation of ammonium and antibody were found to be significantly cell‐cycle‐dependent. The combined approach has a strong potential to improve the understanding of the interplay of population heterogeneities and signal factors in mammalian cell culture.
Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers
Authors: Bertok Tomas , Lorencova Lenka , Chocholova Erika , Jane Eduard , Vikartovska Alica , Kasak Peter , Tkac Jan 
Published: September 2018

AbstractImpedimetric affinity biosensors are, without any doubt, among the most sensitive analytical devices available, offering low limits of detection and wide linear response ranges. There are, however, only a few papers detailing the application of impedimetric biosensors for the analysis of clinically relevant samples with due clinical performance. The fact that these devices have not found their way to any commercial or clinical use to date might be surprising, since an electrochemical assay platform based on portable potentiostats is a success story for monitoring a range of clinical parameters such as ions, haematological indicators and glucose. This review discusses the reasons behind this discrepancy and addresses the barriers to be overcome in order to achieve the point‐of‐care diagnostics using such devices for detection of protein oncomarkers approved by FDA. The final part of the review covers the most recent progress in the area.