bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare cases of laboratory tests discrepancies in diagnostics of pediatric Burkitt lymphoma/leukemia
Authors: Demina I. A. , Illarionova1 O. I. , Verzhbitskaya T. Yu. , Tsaur G. A. , Rusanova E. B. , Gorchakova M. V. , Zueva E. E. , Belogurova M. B. , Uleiskaya G. I. , Shchekina L. A. , Kazakova A. N. , Zerkalenkova E. A. , Olshanskaya Yu. V. , Abugova Yu. G. , Fechina L. G. , Miakova N. V. , Samochatova E. V. , Maschan A. A. , Popov A. M. 
Published: October 2018

Introduction. The main features of bone marrow blasts cells in Burkitt lymphoma/leukemia (BL) are L3 morphology, mature immunophenotype of blasts with surface IgM expression, and presence of typical MYC gene rearrangements.The aim of the study was to show discrepancy examples in laboratory signs of BL.Patients and methods. 10 patients (8 boys and 2 girls) aged 1 to 18 years were included in the present study. The inclusion criterion was the identification of discrepancies between flow cytometric, morphological and cytogenetic data.Results. In 2 cases there were no rearrangements of the MYC gene. In 2 patients, the L2 morphological variant went against the presence of typical MYC gene rearrangements. In one case, undifferentiated blasts cells were described by morphology together with presence of surface IgM, and atypical genetics. In 8 patients, there was no expression of surface IgM. Of these, patients with absence of cytomorphological data cytometric and genetic data were controversial.Сonclusion. The cases presented in this study and the cases described in the literature demonstrate the importance of an attentive and comprehensive approach in evaluating the results of laboratory tests in the diagnosis of BL.
Comparative methodological studies of L-asparaginase encapsulation into erythrocytes
Authors: Borsakova D. V. , Plakhotnik M. E. , Koleva L. D. , Bovt E. A. , Alexandrovich Yu. G. , Ataullakhanov F. I. , Sinauridze E. I. 
Published: October 2018

Background.L-asparaginase is an enzyme, widely used in the therapy of acute lymphoblastic leukemia in children and adults, but its use is limited due to a wide range of side effects and anaphylactic reactions. L-asparaginase loaded into erythrocytes can solve these problems. This enzyme is protected from the immune system and plasma proteases due to erythrocyte membrane, but continues to work inside the cell because its membrane is permeable to L-asparagine. Thus, the half-life of the drug increases and anaphylactic reactions reduce. The encapsulation of L-asparaginase into erythrocytes can be performed by various osmotic methods. Each of them is characterized by the amount of encapsulated enzyme, the cell yield, as well as by the quality indices of the survived erythrocytes. An important parameter of each method is the possibility to provide sterility of this dosage form for the clinical use.The aim of the studywas the comparing of three osmotic methods of L-asparaginase encapsulation into erythrocytes (hypo-osmotic lysis, dialysis and flow dialysis) to select the most promising method for clinical use.Materials and methods.A suspension of erythrocytes of healthy donors (hematocrit 60–70%) was mixed with L-asparaginase from E. сoli. The procedures of hypotonic reversible lysis, dialysis in dialysis bags, or flow dialysis using pediatric dialyzers were performed. The physiological osmolality was restored in suspensions after the procedure by the addition of a hypertonic solution, and they were incubated for 30 min at 37 °C. Then the cells were washed in isotonic phosphate-buffered saline with pH 7.4. Activity of L-asparaginase, volume, hematocrit, hematological indices and osmotic cell fragility of erythrocytes were measured in the suspensions of erythrocytes before and after the enzyme encapsulation procedure.Results.An optimal osmolality of the hypotonic buffer for each method was selected and was equal to 90–110 mOsm/kg. The yields of encapsulation were 4.2 ± 2.0, 6.0 ± 2.3 and 16.2 ± 2.2 % for hypotonic lysis, dialysis and flow dialysis, respectively. The hematological indices of the obtained erythrocyte-carriers differed from the corresponding parameters of the initial erythrocytes, but did not differ significantly for different methods.Conclusion.Comparative investigation of mentioned above parameters allowed choosing the method of flow dialysis as the most promising for clinical use.
Falls in the stationary for patients with cardiovascular diseases of the senior age and polypharmacy
Authors: Ilina E. S. , Bogova O. T. , Sinitsina I. I. , Puzin S. N. , Sychev D. A. 
Published: October 2018

Background.The fall in the elderly is observed much more often than in younger people, and according to statistics the number of people over 65 years who have suffered a fall during the year reaches 30 %, while the probability of injury. Most of the falls in elderly patients does not lead to injury, but the developing at the same time unfavorable psychological discomfort can sharply limit the usual activity, lead to the formation of dependence on outside help, disadaptation in the home and form a fear of a possible fall. Falls, accompanied by the development of trauma, are observed in 10–15 % of cases.The objectivewas to study the relationship between polymorbidity, polypragmasia and the development of the fall in elderly patients cardiological profile.Results.Polymorbidity prevailed in the group of patients who suffered a fall in the hospital (8.9 ± 2.6 vs 7.5 ± 1.5 in men. 8.5 ± 2.2 vs 7.2 ± 1.6 in women). In patients undergoing a decline, it was also noted, and polypharmacy to a greater extent than cohort patients without falling (9.4 ± 1.9 vs 78.4 ± 2.2 in men. and 9.6 ± 2.7 vs 9.1 ± 2.5 for women). In addition, patients who suffered a fall in the hospital by age were older than patients in the comparison group (86 ± 6 vs 85 ± 5 in men, 87 ± 5 vs 84 ± 5 in women). We also revealed the tendency of the predominance of women in the subgroup of patients with the incidence and development of trauma.Conclusion.Minimizing the amount of drugs received, as the fight against polypragmasy can help reduce the incidence of falls in elderly patients.
Validation of the Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale (LANSS) in Russia
Authors: Yusupova D. G. , Suponeva N. A. , Zimin A. A. , Zaytsev A. B. , Bennett M. , Belova N. V. , Gushcha A. O. , Chechotkin A. O. , Gatina G. A. , Polekhina N. V. , Bundhun Pratish , Ashrafov V. M. , Piradov M. A. 
Published: October 2018

Background. Objectivization of the characteristics of neuropathic pain is an important component of differential diagnosis in various diseases. Scales and questionnaires are topical diagnostic tools for assessing subjective symptoms for patients and health professionals.Objectiveto development and validation of the Russian version of the the Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale (LANSS).Materials and methods.The study included two stages: linguocultural ratification and assessment of the psychometric properties of the developed Russian version.Results.The study showed a high level of reliability, validity and sensitivity of the developed Russian-language version of the scale. Conclusion. By the results of the study, the official validated Russian-language version of the scale is presented and recommended for use in work with Russian-speaking patients.
Ultra-High Accurate Attitude Determination and Control of Microsatellite Formation Flight
Authors: DOSZHAN Nursultan , GARİP ALİSHER İbrayev Gulama , ROLAND Pilpani 
Published: October 2018

Nowadays, technology and space science are
developing rapidly, providing new possibilities for multi-segment missions to
become a frequent practice. This relates to small satellites, which could be
used to organize a formation, in order to solve complex scientific and applied
problems. A formation could serve as distributed instruments for atmospheric
sampling, construct a large distributed antenna platform, or make a large
distributed aperture for imaging and other applications what only a big
satellite can achieve. Small satellite’s formation flying is low cost space
project compared to one big satellite. However, to develop satellite formation
a lot of problems should be solved depending on its mission.

One of the important tasks in small
satellite formation is an accurate determination and control of position and
attitude. This paper provides a
mathematical modelling of a small satellite’s formation motion, which is
essential to realize a synthetic aperture telescope. Furthermore, the paper
describes the principle of formation configuration and its design.
Mimicking T- shaped giant meckel's diverticulum: another rare anatomical variant complicating small bowel obstruction by adhesions
Authors: Mannan Ambreen , Alshumari Osama A. E. 
Published: October 2018

We report case with Meckel's diverticulitis complicated by adhesive intestinal obstruction. An adolescent of 13-yr-old boy with history of recurrent right sided lower abdominal pain and vomiting for two days. According to his mother he had been suffering this type of pain intermittently for last three years which was treated conservatively. This time the pain was out of proportion therefore she reported in tertiary hospital. On examination patient was tender at right iliac fossa region with abdominal guarding. CT scan of abdomen revealed multiple fluid-filled, dilated proximal bowel loops. Meckel's diverticulum was not suspected until diagnostic laparoscopy was performed. Patient was converted to open laparotomy where the giant (13 cm sized), narrow base mimicking T-shaped Meckel’s diverticulum and inter bowel loop adhesions near terminal ileum were seen. About 20 cm affected ileal segment with Meckel’s diverticulum resected and primary end to end anastomosis performed. The postoperative course remained uneventful. Histopathology report confirms the inflammation of Meckel’s diverticulum. Significance of this type of Meckel’s diverticulum is its T-shaped mimicking appearance with giant size body and narrow base and was manifested with recurrent sub occlusive intestinal obstruction in the period of three years. It is the second ever reported case in English journals.
Pozzolanic benefit of fly ash and steel slag blends in the development of uniaxial compressive strength of lime stabilized soil
Authors: James Jijo , David Ebenezer Paul Billy Graham , Nagarathinam Mahalakshmi , Thaniyarasu Mohan Kumar , Madhu Jayapal 
Published: October 2018

This investigation involved the examination of pozzolanic benefits that resulted from the amendment of lime stabilization of a soil by using a combination of two industrial wastes viz. Fly ash (FA) and Steel Slag (SS). Two lime contents (6% and 8%), which represented the control specimens, were selected for stabilizing the soil, one above the Initial Consumption of Lime (ICL) and the other above the Optimum Lime Content (OLC), respectively. The lime to total solid waste ratio was maintained as 1:1, and the FA/SS ratio varied within the total solid waste content adopted for amending lime stabilization. The unconfined compressive strength (UCS) of the stabilized samples were determined by casting UCS specimens of 38 x 76 mm and cured for 2 hours, 7, 14 and 28 days. After curing, the specimens were strained until failure, to study the pozzolanic benefits of adding FA-SS. The results revealed that the addition of FA and SS improved the pozzolanic strength, ranging from 3.5% to 15%. The optimal dosage of FA and SS also varied with the lime content adopted. For the 6% lime content, a FA/SS ratio of 1:1 was found to be optimal, whereas for the 8% lime content, a FA/SS ratio of 3:1 was found to develop the maximum strength. The amendment of lime stabilization with FA/SS clearly brought about the difference in lime stabilization stages, unseen when only lime was adopted as stabilizer.
Best Papers from the 2006 CLEI Conference, in Santiago, Chile, August 20-25, 2006
Authors: Leiss Ernst , Andrade Diego , Maldonado Jose Carlos , Simão Adenilso , Visconti Marcello 
Published: October 2018

It gives us great pleasure to introduce the three best papers selected from the papers presented at CLEI 2006 in Santiago, Chile. Following well established tradition, CLEI invited the top papers of the conference for consideration as best papers in a special issue of the CLEI Electronic Journal. For the purpose of selecting these papers, the Comité Directivo of CLEI named a committee consisting of Diego Andrade (Ecuador), Ernst Leiss (USA), José Carlos Maldonado (Brazil), Marcello Visconti (Chile); and Adenilso Simão (Brazil). After a careful review of the ranking obtained from the Program Committee of CLEI 2006, the group agreed to invite six papers. The authors of four papers decided to accept our invitation. These papers were subjected to a further review resulting in the three papers that form this special issue.
On behalf of the selection committee, we would like to thank all people involved in this undertaking, from the authors to the reviewers, and also the SBC – Sociedade Brasileira de Computação for providing the submission system
Integrity Constraint Checking in Distributed Nested Transactions over a Database Cluster
Authors: Gançarski Stephane , León Claudia , Naacke Hubert , Rukoz Marta , Santini Pablo 
Published: October 2018

This paper presents a solution to check referential integrity constraints and conjunctive global constraints in a relational multi database system. It also presents the experimental results obtained by implementing this solution over a PC cluster with Oracle9i DBMS.
The goal of those experimentations is to measure the time spent to check global constraints in a distributed systems. The results show that the overhead induced by our distributed constraint checking is reduced by 50% compared to a centralized checking of constraints.
A Stochastic Concurrent Constraint Based Framework to Model and Verify Biological Systems
Authors: Olarte Carlos , Rueda Camilo 
Published: October 2018

Abstract
Concurrent process calculi are powerful formalisms for modelling concurrent systems. The mathematical style underlying process cal- culi allow to both model and verify properties of a system, thus pro- viding a concrete design methodology for complex systems. ntcc , a constraints-based calculus for modeling temporal non-deterministic and asynchronous behaviour of processes has been proposed recently. Process interactions in ntcc can be determined by partial informa- tion (i.e. constraints) accumulated in a global store. ntcc has also an associated temporal logic with a proof system that can be conve- niently used to formally verify temporal properties of processes. We are interested in using ntcc to model the activity of genes in biological systems. In order to account for issues such as the basal rate of re- actions or binding affinities of molecular components, we believe that stochastic features must be added to the calculus. In this paper we propose an extension of ntcc with various stochastic constructs. We describe the syntax and semantics of this extension together with the new temporal logic and proof system associated with it. We show the relevance of the added features by modelling a non trivial biological system: the gene expression mechanisms of the λ virus. We argue that this model is both more elaborate and compact than the stochastic πcalculus model proposed recently for the same system.
Expert systems in uroflowmetry data evaluation
Authors: Ershov A. V. , Kapsargin F. P. , Berezhnoy A. G. , Miltigashev M. P. 
Published: October 2018

Introduction. In the practice of an urologist, it is customary to assess the type of urination by two parameters: most often it is the effective volume of the bladder (V) and the maximum volume rate of urination (Qmax). Since the expert assessment of the digital characteristics of urine flow is often ambiguous, they are not taken into consideration by some doctors and often remain without due attention. Today there is a tendency in medicine to objectify by quantification of clinical parameters. The main technology used to solve the tasks of data processing and analysis, as well as their classification and forecasting, are artificial neural networks. The aim of the work was to develop an expert system of urine flow rate data recognition based on neural network classifier.Materials and methods. The training of an artificial three-layer neural network of direct distribution occurred according 210 uroflowgrams and a multidimensional vector, characterized by 9 input parameters.Results. The system was tested on 40 examples ‒ uroflowgram data of patients who did not participate in neural network training. Despite this fact, the neural network has identified all the proposed examples correctly.Conclusions. A neural network method for recognition of uroflowmetry data of various diseases of the lower urinary tract is proposed. The space of informative features influencing the assessment of uroflowmetry data is formed. An expert system that classifies diseases (3 types of disorders) of the lower urinary tract with a 95% degree of confidence has been developed.
Symptoms of sexual dysfunction in men with chronic patient patial syndrome / chronic prostatit of III type and depression
Authors: Kryuchkova M. N. , Perechov A. Ya. 
Published: October 2018

Introduction. With CPPS / CP III, symptoms of sexual dysfunction and mental pathology are often simultaneously detected.Goal. Analysis of sexual dysfunction in patients with CPPS / CP IIIA, CPPS / CP IIIB and the existing affective pathology, comparing these groups of patients with CPAP / CP IIIA and IIIB with each other.Materials and methods. 65 men with type III CPAP / CP were examined, 41 patients were included, which comprised 2 comparison groups: 12 patients with CPPS / CP IIIA (group 1) and 29 patients with CPPS / CP IIIB - group 2. All patients did not have testosterone abnormalities, did not respond to standard urological therapy. Diagnosis of mental disorder and sexual dysfunction was established clinico-psychopathologically, the «International Index of Erectile Dysfunction» (ICEF) scale was applied; the severity of the pain was assessed using a visual analog scale (VAS). Statistical calculations were performed in the R Foundation for Statistical Computing, Vienna, Austria, version 3.2.Results. Patients of both groups were diagnosed with a primary depressive episode in the 1st comparison group - 75%, in the 2nd comparison group in 80%; depressive episode within the recurrent (recurrent) depressive disorder - in the 1 group 25%, in the 2 group 7%, in the bipolar affective disorder only in the 1 group - 7%; 1 obsessive-compulsive disorder (Table 1) was diagnosed in 1 patient (3%) in the 2nd group. In both groups, moderate episodes of moderate severity predominated-92% in group 1 and 62% in group 2; Depressive episodes of mild degree were 8% in 1 group and 28% in 2 comparison groups; A severe depressive episode was observed only in the 2nd comparison group at 7%. Erectile dysfunction was detected in 75% of patients in group 1, 93% in patients in group 2, premature ejaculation in group 1 in 58%, in group 2 in 45% of patients, reduction in libido in group 1 in 92%, in group 2 in 100%, pain during the ejaculation in group 1 was presented by 33%, in the 2nd group in 28% of men.Discussion and conclusions. Erectile dysfunction and decreased libido prevailed in patients of both comparison groups, were observed against the background of depressive episodes and, possibly, can be regarded as symptoms of disruption of vital functions within the atypical depressive syndrome of depressive disorders in both groups. ED, decreased libido (sexual desire, desire and attraction), premature ejaculation, general dissatisfaction with sexual intercourse were observed in both groups of patients with CPPS / CP III against a background of depressive episodes, comparing the frequency of occurrence of symptoms of sexual dysfunction does not reveal significant differences in the compared groups. It is advisable to further study the symptoms of sexual dysfunction in CPPS / CP III and psychopathology, their development in the length of the disease, and the relationship for the development of comprehensive CPPS / CP III therapy.
Virus and bacterial associations verified in the urine of healthy subjects (pilot study)
Authors: Naboka Yu. L. , Il’yash A. V. , Krakhotkin D. V. 
Published: October 2018

Introduction. CCurrently, there are more and more new data that the urine of the healthy subject has its own unique microbiota and virobiota. Nevertheless, in the etiology and pathogenesis of the inflammatory diseases of the urinary system, the bacterial component is the most studied, but the viral component, as a rule, remains outside the scope of the standard clinical examination of patients. Objectives. To investigate the viral-bacterial associations in the urine of healthy subjects.Materials and methods. The 20 healthy sexually active women and men were examined, which are divided into groups according to gender: Group I – women (n = 10), Group II – men (n = 10). The average age of the subjects was 22.4 ± 1.2 years.Results. Bacteriological examination showed that in the urine of healthy women predominates Lactobacillus spp. (90,0%), Peptococcus spp. (80.0%), Propionibacterium spp. (70.0%), and in the urine of healthy men - Eubacterium spp. (70.0%) and Peptostreptococcus spp. (40.0%). During the polymerase chain reaction of urine were detected the papilloma (HPV) and herpetic (HSV) viruses in 40.0% of cases. In group I were verified HPV (20.0%) and HSVII (10.0%), in group II was found only the HPV (10.0%). In all cases, when viruses were detected in the urine, they were recorded as part of virus-bacterial associations. In one healthy woman in the urine were found HPV + HSVII associationsConclusions. The findings about of verification different taxa of viruses in the urine of healthy subjects are the basis for understanding and detailing the etiological structure of infections of the urinary system. The further studies should be aimed for increasing the cohort of healthy subjects in order to obtain the correct factograms of bacterial and viral patterns which present in their urine.