bluuebunny/crossref_metadata_2025_split huggingface dataset:
(208) GLOBAL WEB TRENDS ANALYSIS OF SEX TOYS
Authors: Deger MD , Akgül B 
Published: December 2024

Abstract

Introduction
Pleasure is one of the most notable reasons people take part in sexual activity. Sex toys and devices may improve and broaden sexual pleasure while also adding alternatives and excitement to sexual intercourse. As a result, they are popular among women, men, and transgender individuals all around the world.

Objective
This study examined the trends about the most popular preferred sex toys by nation/region from 2009 using data from Google Trends (GT).

Methods
Since 2004, data on the global search traffic for a given Google query, including time period and category trends, has been provided by GT. GT can generate a “line graph” that displays how interest in a certain region has changed over time. The relative search volume (RSV), which ranges from 0 to 100, is used to index search values for certain terms. RSV 100 displays the largest search trends, while RSV 50 represents half of the searches. The top 5 sex toys used globally were chosen as search phrases. These were “dildo”, “vibrator”, “strap-on”, “anal plug” and “masturbator”. From 1 January 2009 to 30 June 2023, the data was included as “worldwide” under the “global” enquiry category. Using linear regression analysis, each polynomial trend line was evaluated. If the p-value was less than 0.05, the result was deemed significant.

Results
In the linear regression analysis, the trends by strength were sorted as follows: dildo, vibrator, strap-on, anal plug, and masturbator. In 2018, vibrator surpassed strap-on and came in second, while the regression analysis showed a positive trend for dildo between 2009 and 2016 (p = 0.014). It had a negative trend after 2016. Strap-on was the only one to have a downward trend (p = 0.029) Regression analysis revealed positive trends for vibrator and masturbator (p = 0.030, p = 0.045). The upward trends have continued uninterruptedly since 2009 (Table 1).In global trends, the dildo had strong trends in Northern Europe, vibrator in Eastern Europe, strap-on in the Aegean region, anal plug in South America, and masturbator in Central Europe (Fig. 1).

Conclusions
People from all around the world use the internet to acquire sex toys and devices with increasing interest in order to improve their sexual pleasure and add alternatives and excitement to sexual intercourse. In this sense, various industries can use web trends as a useful indicator for sales policies. Considering their compatibility with technological development, clinical use and side effect profiles, the most important trend increase was in favor of vibrators, followed by masturbators. Future studies should evaluate the balance of negative and positive effects of different types of sexual products and sales policies with objective scales in line with these results.

Disclosure
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(212) ASSESSING THE ROBUSTNESS OF SILDENAFIL CITRATE ORODISPERSIBLE FILMS: A MULTI-FACETED STABILITY STUDY
Authors: Jannini EA , Vignesh SO , Hassan T 
Published: December 2024

Abstract

Introduction
Sildenafil citrate Orodispersible film (ODF) is a novel formulation designed to better address the needs and expectations of men with erectile dysfunction (ED). Ensuring the stability of pharmaceutical products is crucial to maintain their efficacy, safety, and quality throughout their shelf-life.

Objective
This study aimed to perform a stress test on sildenafil ODF by exposing it to elevated temperatures (60 degrees Celsius) mimicking extreme storage conditions and evaluate its physical and chemical stability.

Methods
This test was conducted in Kyukyu Pharmaceutical Co., Ltd, Toyama Plant, Japan. A thin pale red colored ODF containing 50 mg sildenafil was formulated to dissolve in the oral cavity. Three batches of samples were subjected to a stability study at 60°C stress for three weeks. They were assessed for the amount of active pharmaceutical ingredient assay (95.0% −105.0% of labelled amount), degradation, disintegration, dissolution rate (over 80% for 45 mm) and water content.

Results
All test items met the specifications and showed negligible differences between the samples. The amount of degradation products demonstrated an increasing trend over time in all conditions, but all met the specification. The purity testing for degradation product (0.2% or less) showed significant (p value &lt;0.05) at initial and 60°C in all the three samples.

Conclusions
The process was evaluated across a range of manufacturing conditions, and all intermediates and sildenafil ODF showed consistent performance that yields a consistent product meeting all specifications at release and after three weeks of storage under stressed conditions. These results indicate the robust performance of the sildenafil ODF across a range of manufacturing conditions. In addition, the water content stayed in a tight range regardless of the film casting parameters, and this remains true of the packaged product even after 3 weeks at 60°C.

Disclosure
Yes, this is sponsored by industry/sponsor: Kyukyu Pharmaceutical Co., Ltd, Toyama Plant, Japan and Viatris Inc.
Clarification: Industry initiated, executed and funded study.
Any of the authors act as a consultant, employee or shareholder of an industry for: Viatris Inc.
(220) EPIDEMIOLOGICAL PROFILE OF PATIENTS UNDERGOING PENILE DOPPLER ULTRASOUND AT A FEDERAL UNIVERSITY HOSPITAL IN BRAZIL
Authors: Fernandes Negris Lima V , Almeida G , Gamberini P , Milanez C , Fitaroni ML , Borges C 
Published: December 2024

Abstract

Introduction
Erectile Dysfunction (ED) refers to the inability to achieve or sustain a satisfactory erection for sexual intercourse. In Brazil, the estimated prevalence of ED among adults aged 40 to 70 years is notably high at 42.1%. For the evaluation of primary erectile dysfunction and preoperative assessment of Peyronie’s disease, Penile Doppler ultrasound, involving drug-induced and audiovisual self-stimulation, is recommended.

Objective
This study aims to provide insights into the epidemiology of patients undergoing penile Doppler ultrasound at a Federal University Hospital.

Methods
This retrospective study gathered data from the electronic medical records of 165 patients who underwent the examination between March 2021 and March 2023, using the Phillips Affiniti 50G device and erotic material for audiovisual stimulation. Pharmacological induction with 10 mcg/ml Alprostadil, 30 mg/ml Papaverine, and 1 mg/ml Phentolamine. Initially, 0.1 ml of this mixture was applied to the penile shaft, with subsequent adjustments made to achieve the best maximal erection.

Results
The participants ages ranged from 20 to 80 years, with an average of 59.8(±11,42) years. Marital status distribution showed 132 married and 33 were single. Ethnically, there were 57 white, 69 individuals of mixed race, and 39 black. The average Body Mass Index was 26.6(±4,13). The majority of patients identified as heterosexual (160 patients), while 3 homosexual, and 2 bisexual. Prevalent medical conditions included 51 cases of hypertension, 31 cases of diabetes, and 13 cases of both. Additionally, 62 patients had radical prostatectomy. Out of the 138 patients that performed the exam with the report of erectile dysfunction, 54 were diagnosed with arterial insufficiency and 09 had venous leakage. Among the 42 exlcusive clinical report of Peyronie’s, 6 patients were identified arterial insufficiency and 01 had venous leakage, 76% exhibited a uniplanar curvature, primarily located in the dorsal region. The average curvature angle was 47°(±19,5).

Conclusions
Erectile dysfunction was significantly more prevalent than Peyronie’s disease. Among Peyronie’s patients, uniplanar curvature, especially in the dorsal region, was the most common deformity type.

Disclosure
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(221) ERECTILE DYSFUNCTION: THE CANARY IN THE COALMINE OF MEN’S HEALTH AND IMPULSION IN PUBLIC POLICIES
Authors: Jannini EA , Vignesh SO , Hassan T 
Published: December 2024

Abstract

Introduction
The onset of erectile dysfunction (ED) is attributed to organic and nonorganic factors that can mirror the state of an individual’s general health. Public health policies have the potential to leverage ED as a marker for non-communicable diseases that burden healthcare systems worldwide. Recognizing ED as an early warning sign facilitates reframing of public health policies to integrate preventive strategies, screening, and education campaigns.

Objective
This study aims to address the interconnectedness of men’s health issues with ED to reduce morbidity and enhance men’s quality of life.

Methods
We developed an expert consensus on addressing ED within the framework of public health policy, which requires an understanding of its multifaceted etiology and implications. We reviewed the epidemiology of ED, its association with systemic health conditions, and the imperative for public health policymakers to prioritize men’s sexual health as a window to overall well-being.

Results
Public health policies must advocate for comprehensive sexual health education that demystifies ED and encourages early medical consultation. Policy interventions should make recommendations for incorporating ED screening into routine health check-ups, subsidizing treatment options to enhance accessibility, promoting public awareness campaigns on the link between lifestyle factors and ED, and strengthening mental health support systems that recognize the psychological impact of ED.

Conclusions
ED, as an early detector of potential health threats, provides a unique opportunity for public health practitioners to broaden the scope of men’s health initiatives. By harnessing the predictive value of ED for more severe conditions, public health policies can galvanize an integrative health movement that promotes longevity and well-being for men, ultimately serving the community at large. Public health policies that acknowledge the sentinel role of ED offer a strategic entry point for addressing systemic health concerns, thus improving outcomes for individuals and populations.

Disclosure
Yes, this is sponsored by industry/sponsor: Viatris.
Clarification: Industry initiated, executed and funded study.
Any of the authors act as a consultant, employee or shareholder of an industry for: Viatris.
(230) A NEW TECHNIQUE OF MODIFIED PROSTATE W-POINT MASSAGE
Authors: Wang Q 
Published: December 2024

Abstract

Introduction
Palpation and fluid extraction of the prostate are necessary means for the clinical diagnosis of prostate diseases.

Objective
To introduce a new modified technique of Prostate W-point Massage(PWM) and explore its effectiveness in the diagnosis and treatment of prostate diseases.

Methods
A total of 200 patients with prostatic inflammation and hyperplasia were randomly divided into experimental group and control group. The patients in the control group were treated with traditional prostate massage method, the patients in the experimental group were massaged with the modified Prostate W-point Massage method (the massage path was similar to the letter W), to analyze the effectiveness of two massage techniques on the success rate of prostatic fluid extraction and the therapeutic effect of prostatic diseases.

Results
There was no significant difference between the two groups before massage (P &gt; 0.05). The success rate of prostate massage fluid extraction in the experimental group was higher than that in the control group (p &lt; 0.05), and the effective rate of clinical symptom relief in the experimental group was higher than that in the control group (p &lt; 0.05).

Conclusions
1. The application of the PWM technique in patients with prostate diseases is effective, which not only increases the success rate of fluid extraction, but also helps to relieve the clinical symptoms of various prostate diseases. 2. At the same time, PWM can promote erection and sexual pleasure. After the prostate disease was cured, most of them asked to continue massage.

Disclosure
No.
(238) SEXUAL AROUSAL DISORDER: THE 2024 STUDY
Authors: Vastrad B 
Published: December 2024

Abstract

Introduction
Sexual Arousal Disorder (SAD) is a prevalent and distressing condition characterized by the persistent or recurrent inability to attain or maintain adequate sexual excitement. Despite its significance, SAD remains poorly understood, with limited research addressing its multifaceted aetiology and effective Management strategies. Understanding the underlying mechanisms of SAD is crucial for the development of targeted interventions to alleviate the associated distress and enhance sexual well-being.

Objective
This study aimed to investigate the prevalence, correlates, and psychosocial factors associated with sexual arousal disorder in a diverse population sample. Additionally, we sought to explore the potential efficacy of various treatment modalities in managing SAD and improving sexual functioning, and well-being.

Methods
A cross-sectional study was conducted among a representative sample of individuals aged 18 to 75 years, recruited from diverse demographic backgrounds. Participants completed validated questionnaires assessing sexual function, psychological well-being, relationship satisfaction, and demographic variables. Clinical interviews and standardized assessments were conducted to assess/diagnose SAD according to established criteria. Statistical analyses, including regression models and correlation analyses, were employed to examine the relationships between SAD and various factors.

Results
Our findings revealed a significant prevalence of sexual arousal disorder within the study population, with notable associations with psychological distress, relationship dissatisfaction, and comorbid mental health conditions. Moreover, demographic factors such as age, gender, and relationship status demonstrated differential impacts on the prevalence and manifestation of SAD. Importantly, we identified specific psychosocial factors that significantly contributed to the development and persistence of SAD, highlighting the importance of addressing contextual influences in treatment interventions. Furthermore, our investigation into management modalities indicated promising outcomes for psychotherapy, pharmacotherapy, and combination approaches in alleviating symptoms of SAD and enhancing sexual satisfaction, the Quality Of Life (QOL), the Quality Of Life-Style (QOLS) and the Quality Of Life Years (QOLY).

Conclusions
This study contributes to the growing body of literature on sexual arousal disorder by elucidating its prevalence, correlates, and treatment implications within a diverse population sample. Our findings underscore the complex interplay of biological, psychological, and social factors in the etiology and maintenance of SAD, emphasizing the need for comprehensive and individualized approaches to assessment and intervention. By addressing the multifaceted nature of SAD, clinicians and researchers can advance the development of targeted and effective interventions to improve Quality Of sexual health, Quality Of Life and overall well-being.

Disclosure
No.
(241) VENTRAL CORPORAL REINFORCEMENT USING PERICARDIUM ALLOGRAFT (TUTOPLAST®) IN A PATIENT UNDERGOING URETHRECTOMY PROCEDURE WITH AN INFLATABLE PENILE PROSTHESIS IN PLACE: CASE REPORT
Authors: Mahdi M , Leung S , Pettaway C , Wang R 
Published: December 2024

Abstract

Introduction
Erectile dysfunction (ED) is a common consequence following radical cystectomy (RC), with inflatable penile prostheses (IPP) placement considered as the gold standard for refractory cases. Urethral recurrence post-RC necessitates urethrectomy, which poses challenges for patients with in place IPP. The thinning of the ventral tunica albuginea during urethrectomy may increase the risk of corporal disruption and IPP cylinder aneurysm, affecting device functionality.

Objective
To introduces a novel surgical technique using Tutoplast, a human-derived pericardium allograft, for corporal reinforcement during urethrectomy in the presence of in-situ IPP.

Methods
74-year-old male, with history of robotic-assisted RC and IPP presented with recurrent blood per urethra. Imaging revealed urethral masses (Fig. A). The patient underwent total urethrectomy, resulted in significant thinning of the ventral tunica albuginea. The decision was then made intra-operatively to repair and reinforce the thin tunica albuginea to prevent the risk of tunica and device aneurysm or mechanical failure. The thin tunica albuginea was covered with Tutoplast graft. Two graft pieces were used and sutured to the lateral, superior and inferior aspects of both corpora, covering a total area of 3 x 10 cm (Fig. B). To ensure IPP cylinders integrity during graft suture, we inflated them to minimize kinks and we used a pick-up instrument to catch and raise the corpora for safe needle passage.

Results
Final pathology of the urethra showed high-grade papillary urothelial carcinoma with invasion of the corpus spongiosum, negative margins. At the six weeks follow up visit, patient was recovering well. Cycling of the IPP done smoothly and the patient was given permission to start using the device. Patient was seen again at six months; he was using the implant without issues and the examination showed good functionality of the implant (Fig. C).

Conclusions
Corporal reinforcement using Tutoplast during urethrectomy in patients with existing IPP presents a simple and cost-effective solution to mitigate the risks of corporal disruption and IPP cylinder aneurysms. The positive outcome demonstrated in this case report warrants further studies on larger patient populations and longer follow-up periods to assess the long-term outcomes of this technique.

Disclosure
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(244) THE IMPACT OF FUNCTIONAL TRAINING AND EMS ON WOMEN’S WELL-BEING AND REPRODUCTIVE HEALTH IN TERMS OF SEXUAL SATISFACTION
Authors: Zborowska K , Krzysztofik S , Violetta S 
Published: December 2024

Abstract

Introduction
Physical activity is important for both the physical and mental health of women, especially after childbirth. Therefore, it is important to adapt physical activity to individual conditions and gradually increase the intensity and load.

Objective
Celem badania jest ocena aktywności fizycznej i oceny dna miednicy w zakresie wpływu innowacyjnego treningu EMS na dobrostan kobiet i aspekty dotyczące sfery seksualnej. The aim of the study is to evaluate physical activity and pelvic floor assessment in terms of the impact of innovative EMS training on women’s well-being and aspects related to the sexual sphere.

Methods
Ten women after giving birth and after the postpartum period were included in the study. They were recruited as part of the Childbirth School classes. Women were introduced to EMS technology training and functional training, which was performed once a week for a period of 6 months. The assessment of the tested parameters was performed in the following time interval: Stage 0 - preliminary examination; Stage 1: examination after 3 months; Stage 2 – examination after 6 months. The following parameters were examined: Assessment of general physical fitness (in order to select the appropriate level of functional training and EMS and to assess general physical activity and its changes over time); Assessment of muscle strength - EMG; Assessment of pelvic floor structures: EMG Biofeebeck - intravaginal and ultrasoundsonofeedback; Questionnaires: MSEI - Multidimensional Self-Assessment Questionnaire, FSFI - Assessment of Sexual Functioning; Questionnaire for the Assessment of Urogynecological Dysfunctions; Gynecological and obstetric history questionnaire; Rosenberg Self-Esteem Scale; Body Assessment – BES; Assessment of BMI parameters and body mass composition, SF-36 Quality of Life Questionnaire.

Results
The study showed that postpartum women who attended training using EMS technology achieved higher physical fitness and improvement in the functionality of the pelvic floor significantly faster. It has also been shown that training using EMS technology has a positive impact on women’s sexual quality and satisfaction, which translates into their overall well-being in terms of everyday functioning and body assessment.

Conclusions
Training using EMS technology allows for greater effectiveness, comfort and more precise personalization of training for women with special needs after childbirth in a shorter period of time.

Disclosure
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(245) THE USE OF THE 75CC CLOVERLEAF PENILE IMPLANT RESERVOIR AS A STANDARD FOR ALL CYLINDER LENGTHS, INCLUDING LONG CYLINDERS
Authors: Mahdi M , Majzoub A , Wang R 
Published: December 2024

Abstract

Introduction
The Titan inflatable penile prosthesis (IPP) utilizes a Cloverleaf reservoir system that comes in two different sizes: 75 cc and 125 cc. The larger reservoir is used for longer cylinders, and in such cases, patients need more time and efforts to inflate the device. Moreover, Larger reservoirs might be associated with higher incidence of reservoir palpability and discomfort especially in the cases of ectopic placement.

Objective
We aim to evaluate the outcome of a technique utilizing the 75 cc reservoir for all cylinder sizes, in which larger cylinders are partially filled with an extra 10-30 cc of saline to compensate for the needed amount of saline.

Methods
Patients who underwent Titan Coloplast IPP using 75 cc reservoir were included. They were classified into group 1 {cylinders &lt;20 cm (n = 104)} and group 2 {cylinders ≥20 cm (n = 107)}. Data regarding patients’ characteristics, surgical details and procedure outcomes including complication rates and patient satisfaction were retrieved. Patients’ satisfaction was reported using The Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) score. Baseline characteristics and complication rates were compared using Chi-square test. T-test was used to evaluate the difference in the satisfaction rate between the 2 groups.

Results
There was no significant difference between the 2 groups with regards to patients’ baseline data. (table 1). During follow up, the overall early and late complication rates in the entire sample were 1.5% and 7.6% respectively. 16 patients developed late complications, including mechanical failure (n = 11), corporal erosion (n = 2), cold glans (n = 2) and chronic pain (n = 1). Comparing the early & late complication rates between the two groups, there was no statistically significant differences (P = 0.386 and P = 0.753 respectively). While the mechanical failure rate was higher among group1 (6.7% vs. 3.7%), the difference was not statistically significant. The satisfaction score means were 93.5% and 87% for patients in group 1 and group2 respectively, the difference didn’t reach a statistically significance level. (P = 0.25).

Conclusions
Using 75 cc IPP reservoir for large cylinders with the addition of extra amount of saline to the cylinders is feasible with no significant negative outcome. Using such technique achieves easier and faster device inflation, associated with less chance of reservoir palpability and bothersome, and might help to give more options for reservoir placement location.

Disclosure
No.