bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal perfusion parameters measured by contrast‐enhanced ultrasound in healthy dogs demonstrate a wide range of variability in the long‐term
Authors: Liu Daisy J.X. , Hesta Myriam , Stock Emmelie , Bogaerts Evelien , Broeckx Bart J.G. , Saunders Jimmy H. , Vanderperren Katrien 
Published: October 2018

AbstractContrast‐enhanced ultrasound may be helpful for detecting early renal microvascular damage and dysfunction in dogs. However, before this noninvasive imaging method can be tested as an early‐stage screening tool in clinical patients, an improved understanding of long‐term variation in healthy animals is needed. In this prospective, secondary, longitudinal, serial measurements study, variability of contrast‐enhanced ultrasound renal perfusion parameters was described for eight healthy dogs, using seven time points and a period of 83 weeks. Dogs were sedated with butorphanol (0.4 mg/kg), and contrast‐enhanced ultrasound of each kidney was performed after an intravenous bolus injection of a microbubble contrast agent (0.04 mL/kg). Time‐intensity curves were created from regions‐of‐interest drawn in the renal cortex and medulla. Intensity‐related parameters representing blood volume and time‐related parameters representing blood velocity were determined. A random‐effects model using restricted maximum likelihood was used to estimate variance components. Within‐dog coefficient of variation was defined as the ratio of the standard deviation over the mean. Time‐related parameters such as time‐to‐peak, rise and fall time had lowest within‐dog variability. Intensity‐related parameters such as peak enhancement, wash‐in and wash‐out area under the curve, total area under the curve, and wash‐in and washout rates had high within‐dog variability (coefficient of variation > 45%). Authors therefore recommend the use of time‐related parameters for future studies of renal perfusion. Within‐dog variability for bilateral kidney measurements was extremely low, therefore contrast‐enhanced ultrasound may be particularly useful for detecting unilateral changes in renal perfusion. Future studies are needed to compare contrast‐enhanced ultrasound findings in healthy dogs versus dogs with renal disease.
Effects of the ‘11+ Kids’ injury prevention programme on severe injuries in children’s football: a secondary analysis of data from a multicentre cluster-randomised controlled trial
Authors: Beaudouin Florian , Rössler Roland , aus der Fünten Karen , Bizzini Mario , Chomiak Jiri , Verhagen Evert , Junge Astrid , Dvorak Jiri , Lichtenstein Eric , Meyer Tim , Faude Oliver 
Published: October 2018

BackgroundTo assess the effects of the injury prevention programme ‘11+ Kids’ on reducing severe injuries in 7 to 13 year old football (soccer) players.MethodsFootball clubs (under-9, under-11 and under-13 age groups) from the Czech Republic, Germany, the Netherlands and Switzerland were cluster-randomised (clubs) into an intervention (INT) and a control group (CON). INT replaced their usual warm-up by ‘11+ Kids’ two times a week. CON followed their regular training regime. Match and training exposure and injury characteristics were recorded and injury incidence rates (IRs) and 95% CIs calculated. For the present analysis, only severe injuries (absence from training/match ≥28 days) were considered. Hazard ratios (HR) were calculated using extended Cox models.ResultsThe overall IR of severe injuries per 1000 football hours was 0.33 (95% CI 0.25 to 0.43) in CON and 0.15 (95% CI 0.10 to 0.23) in INT. There was a reduction of severe overall (HR 0.42, 95% CI 0.24 to 0.72), match (0.41, 0.17 to 0.95) and training injuries (0.42, 0.21 to 0.86) in INT. The injury types that were prevented the most were: other bone injuries 66%, fractures 49% and sprains and ligament injuries 37%. Severe injuries located at the knee (82%), hip/groin (81%), the foot/toe (80%) and the ankle (65%) were reduced tremendously.Conclusions‘11+ Kids’ has a large preventive effect on severe injuries by investing only 15 to 20 min per training session. The present results should motivate coaches to implement effective injury prevention programmes such as the ‘11+ Kids’ in children’s football.Trial registration numberNCT02222025.
Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction (DAPT-STEMI): randomised, multicentre, non-inferiority trial
Authors: Kedhi Elvin , Fabris Enrico , van der Ent Martin , Buszman Pawel , von Birgelen Clemens , Roolvink Vincent , Zurakowski Alexander , Schotborgh Carl E , Hoorntje Jan C A , Eek Christian Hasbø , Cook Stéphane , Togni Marco , Meuwissen Martijn , van Royen Niels , van Vliet Ria , Wedel Hans , Delewi Ronak , Zijlstra Felix 
Published: October 2018

Abstract

Objective
To show that limiting dual antiplatelet therapy (DAPT) to six months in patients with event-free ST-elevation myocardial infarction (STEMI) results in a non-inferior clinical outcome versus DAPT for 12 months.

Design
Prospective, randomised, multicentre, non-inferiority trial.

Setting
Patients with STEMI treated with primary percutaneous coronary intervention (PCI) and second generation zotarolimus-eluting stent.

Participants
Patients with STEMI aged 18 to 85 that underwent a primary PCI with the implantation of second generation drug-eluting stents were enrolled in the trial. Patients that were event-free at six months after primary PCI were randomised at this time point.

Interventions
Patients that were taking DAPT and were event-free at six months were randomised 1:1 to single antiplatelet therapy (SAPT) (ie, aspirin only) or to DAPT for an additional six months. All patients that were randomised were then followed for another 18 months (ie, 24 months after the primary PCI).

Main outcome measures
The primary endpoint was a composite of all cause mortality, any myocardial infarction, any revascularisation, stroke, and thrombolysis in myocardial infarction major bleeding at 18 months after randomisation.

Results
A total of 1100 patients were enrolled in the trial between 19 December 2011 and 30 June 2015. 870 were randomised: 432 to SAPT versus 438 to DAPT. The primary endpoint occurred in 4.8% of patients receiving SAPT versus 6.6% of patients receiving DAPT (hazard ratio 0.73, 95% confidence interval 0.41 to 1.27, P=0.26). Non-inferiority was met (P=0.004 for non-inferiority), as the upper 95% confidence interval of 1.27 was smaller than the prespecified non-inferiority margin of 1.66.

Conclusions
DAPT to six months was non-inferior to DAPT for 12 months in patients with event-free STEMI at six months after primary PCI with second generation drug-eluting stents.

Trial registration

Clinicaltrials.gov
NCT01459627
.
Improved diabetes medication convenience and satisfaction in persons with type 2 diabetes after switching to insulin glargine 300 U/mL: results of the observational OPTIN-D study
Authors: Wieringa Thomas H , de Wit Maartje , Twisk Jos WR , Snoek Frank J 
Published: October 2018

ObjectiveInsulin glargine 300 (Gla-300) provides less hypoglycemia risk and more flexibility in injection time. The extent to which these effects translate into improved patient-reported outcomes (PROs) is unknown, and is the subject of this observational study.Research design and methodsAdults with type 2 diabetes treated with basal insulin for at least 6 months initiating Gla-300 were included. Data were collected at baseline (start Gla-300) and at 3-month and 6-month follow-up. Patients and physicians gave reasons for switching to Gla-300 at baseline and the extent to which Gla-300 fulfilled their expectations at 6 months. Mixed model analyses examined PRO changes over time, with emotional well-being (WHO-5 Well-Being Index) as the primary outcome. The secondary outcomes were hypoglycemia incidence, hemoglobin A1c (HbA1c), hypoglycemia worries (worry subscale of the Hypoglycemia Fear Survey), diabetes distress (short form of the Dutch version of the Problem Areas In Diabetes Scale), diabetes medication convenience (Diabetes Medication System Rating Questionnaire (DMSRQ)), sleep quality and duration (Pittsburgh Sleep Quality Index), and adherence (Summary of Diabetes Self-Care Activities).Results162 patients participated: 53.70% were men, the mean age was 65.54 years (9.05), baseline mean HbA1c was 7.87% (1.15) (62.48 mmol/mol (12.61)), and mean diabetes duration was 15.14 years (6.65). Mean WHO-5 Well-Being Index scores improved non-significantly from 61.94 (19.52) at baseline (T0) to 63.83 (19.67) at 6 months (T2). Mean DMSRQ scores improved significantly from 32.96 (9.02) (T0) to 36.70 (8.85) (T2) (p<0.001). Dose (less volume) was a switching reason in 69.60% of patients and 63% of physicians, and flexibility in 33.30% and 24.70%, respectively. Gla-300 fulfilled the expectations or even better than expected in 92.30% of patients and 88.90% of physicians.ConclusionIn a relatively well-controlled sample of adults with type 2 diabetes, switching to Gla-300 improves diabetes medication convenience.
Top 50 most-cited articles in medicine and science in football
Authors: Brito João , Nassis George P , Seabra André T , Figueiredo Pedro 
Published: October 2018

ObjectivesTo conduct a comprehensive mapping analysis to the scientific literature published in football aiming to identify the areas of bigger interest and potential for further exploration.MethodsThe data were obtained by a search conducted on the Web of Science. Articles were listed based on citation frequency. We used an open-source bibliometrix R-package for the comprehensive bibliometric analyses.ResultsThe number of citations per article ranged from 251 to 869 (median 323; IQR 125). The yearly number of citations ranged from 8 to 54 (median 26; IQR 11). Most of the articles (76%) were of level III of evidence, 10% were level II and 14% were level IV. Within the top 50 most-cited articles, 40 articles were original research (37 observational and 3 experimental studies), 9 were review articles and 1 was a thesis. From the 40 original research articles, 50% involved elite players, 73% were exclusive to male players and 80% involved adult players only. The topic area with the highest number of articles was sports medicine (44%), followed by training and testing (32%), performance analysis (14%) and physiology (10%). No study within the top 50 was devoted to biomechanics, nutrition, sport psychology, coaching or social sciences.ConclusionsThe lack of experimental studies within the top 50 most-cited articles in football clearly underpins how far we still are from establishing the theoretical and methodological guidelines for the applied science and medicine in football.
Development and validation of a screening instrument for cognitive fluctuation in patients with neurocognitive disorder with Lewy bodies (NCDLB): the Mayo Fluctuations Scale-Thai version
Authors: Thaipisuttikul Papan , Chittaropas Pitchayawadee , Wisajun Pattaraporn , Jullagate Sudawan 
Published: October 2018

BackgroundPrevalence of neurocognitive disorder with Lewy bodies (NCDLB) is low in Asian populations, which may partially reflect its diagnostic difficulty. The Mayo Fluctuations Scale, a short questionnaire that evaluates cognitive fluctuation, has been shown to significantly differentiate NCDLB from Alzheimer’s disease.AimThis study aimed to develop the Mayo Fluctuations Scale-Thai version and assess its validity to screen NCDLB in an elderly population.MethodsThe Mayo Fluctuations Scale was translated into Thai. The process involved back-translation, cross-cultural adaptation, field testing of the prefinal version, as well as final adjustments. From all patients attending the Psychiatric and Memory Clinic at Ramathibodi Hospital, 135 patients accompanied by their primary caregivers were included. Caregivers were interviewed by research assistants using a four-item scale, and psychiatrists determined patients’ diagnosis based on the diagnostic and statistical manual of mental disorders (DSM)-5 criteria. Evaluations performed by psychiatrists and research assistants were blinded.Results Seventeen participants had been diagnosed with major NCDLB. At a cut-off score of 2 or over, the Mayo Fluctuations Scale exhibited excellent performance to differentiate major NCDLB from other major neurocognitive disorders (NCDs), with a sensitivity of 94.1% and a specificity of 71.4%, and acceptable performance to differentiate mild NCDLB from other mild NCDs, with a sensitivity of 60% and a specificity of 93.1%.ConclusionThe Mayo Fluctuations Scale-Thai version is an excellent screening tool for major NCDLB and an acceptable tool that may be used with other additional tests for mild NCDLB. The tool is practical for use in memory and psychiatric clinics. Further validation studies in participants with other specific clinical conditions are required.
Impact of body mass index on the outcome of catheter ablation of atrial fibrillation
Authors: Glover Benedict M , Hong Kathryn L , Dagres Nikolaos , Arbelo Elena , Laroche Cécile , Riahi Sam , Bertini Matteo , Mikhaylov Evgeny N , Galvin Joseph , Kiliszek Marek , Pokushalov Evgeny , Kautzner Josef , Calvo Naiara , Blomström-Lundqvist Carina , Brugada Josep 
Published: October 2018

ObjectivesThe association between obesity and atrial fibrillation (AF) is well-established. We aimed to evaluate the impact of index body mass index (BMI) on AF recurrence at 12 months following catheter ablation using propensity-weighted analysis. In addition, periprocedural complications and fluoroscopy details were examined to assess overall safety in relationship to increasing BMI ranges.MethodsBaseline, periprocedural and follow-up data were collected on consecutive patients scheduled for AF ablation. There were no specific exclusion criteria. Patients were categorised according to baseline BMI in order to assess the outcomes for each category.ResultsAmong 3333 patients, 728 (21.8%) were classified as normal (BMI <25.0 kg/m2), 1537 (46.1%) as overweight (BMI 25.5–29.0 kg/m2) and 1068 (32.0%) as obese (BMI ≥30.0 kg/m2). Procedural duration and radiation dose were higher for overweight and obese patients compared with those with a normal BMI (p=0.002 and p<0.001, respectively). An index BMI ≥30 kg/m2led to a 1.2-fold increased likelihood of experiencing recurrent AF at 12-months follow-up as compared with overweight patients (HR 1.223; 95% CI 1.047 to 1.429; p=0.011), while no significant correlation was found between overweight and normal BMI groups (HR 0.954; 95% CI 0.798 to 1.140; p=0.605) and obese versus normal BMI (HR 1.16; 95% CI 0.965 to 1.412; p=0.112).ConclusionsPatients with a baseline BMI ≥30 kg/m2have a higher recurrence rate of AF following catheter ablation and therefore lifestyle modification to target obesity preprocedure should be considered in these patients.
Loss of RBMS3 Confers Platinum Resistance in Epithelial Ovarian Cancer via Activation of miR-126-5p/β-catenin/CBP signaling
Authors: Wu Geyan , Cao Lixue , Zhu Jinrong , Tan Zhanyao , Tang Miaoling , Li Ziwen , Hu Yameng , Yu Ruyuan , Zhang Shuxia , Song Libing , Li Jun 
Published: October 2018

Abstract

Purpose:
The development of resistance to platinum-based chemotherapy remains the unsurmountable obstacle in cancer treatment and consequently leads to tumor relapse. This study aims to investigate the mechanism by which loss of RBMS3 induced chemoresistance in epithelial ovarian cancer (EOC).

Experimental Design:
FISH and IHC were used to determine deletion frequency and expression of RBMS3 in 15 clinical EOC tissues and 150 clinicopathologically characterized EOC specimens. The effects of RBMS3 deletion and CBP/β-catenin antagonist PRI-724 in chemoresistance were examined by clone formation and Annexin V assays in vitro, and by intraperitoneal tumor model in vivo. The mechanism by which RBMS3 loss sustained activation of miR-126-5p/β-catenin/CBP signaling and the effects of RBMS3 and miR-126-5p competitively regulating DKK3, AXIN1, BACH1, and NFAT5 was explored using CLIP-seq, RIP, electrophoretic mobility shift, and immunoblotting and immunofluorescence assays.

Results:
Loss of RBMS3 in EOC was correlated with the overall and relapse-free survival. Genetic ablation of RBMS3 significantly enhanced, whereas restoration of RBMS3 reduced, the chemoresistance ability of EOC cells both in vitro and in vivo. RBMS3 inhibited β-catenin/CBP signaling through directly associating with and stabilizing multiple negative regulators, including DKK3, AXIN1, BACH1, and NFAT5, via competitively preventing the miR-126-5p–mediated repression of these transcripts. Importantly, cotherapy of CBP/β-catenin antagonist PRI-724 induced sensitization of RBMS3-deleted EOC to platinum therapy.

Conclusions:
Our results demonstrate that genetic ablation of RBMS3 contributes to chemoresistance and PRI-724 may serve as a potential tailored treatment for patients with RBMS3-deleted EOC.
Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
Authors: Kaur Amanpreet , Ecker Brett L. , Douglass Stephen M. , Kugel Curtis H. , Webster Marie R. , Almeida Filipe V. , Somasundaram Rajasekharan , Hayden James , Ban Ehsan , Ahmadzadeh Hossein , Franco-Barraza Janusz , Shah Neelima , Mellis Ian A. , Keeney Frederick , Kossenkov Andrew , Tang Hsin-Yao , Yin Xiangfan , Liu Qin , Xu Xiaowei , Fane Mitchell , Brafford Patricia , Herlyn Meenhard , Speicher David W. , Wargo Jennifer A. , Tetzlaff Michael T. , Haydu Lauren E. , Raj Arjun , Shenoy Vivek , Cukierman Edna , Weeraratna Ashani T. 
Published: October 2018

AbstractPhysical changes in skin are among the most visible signs of aging. We found that young dermal fibroblasts secrete high levels of extracellular matrix (ECM) constituents, including proteoglycans, glycoproteins, and cartilage-linking proteins. The most abundantly secreted was HAPLN1, a hyaluronic and proteoglycan link protein. HAPLN1 was lost in aged fibroblasts, resulting in a more aligned ECM that promoted metastasis of melanoma cells. Reconstituting HAPLN1 inhibited metastasis in an aged microenvironment, in 3-D skin reconstruction models, and in vivo. Intriguingly, aged fibroblast-derived matrices had the opposite effect on the migration of T cells, inhibiting their motility. HAPLN1 treatment of aged fibroblasts restored motility of mononuclear immune cells, while impeding that of polymorphonuclear immune cells, which in turn affected regulatory T-cell recruitment. These data suggest that although age-related physical changes in the ECM can promote tumor cell motility, they may adversely affect the motility of some immune cells, resulting in an overall change in the immune microenvironment. Understanding the physical changes in aging skin may provide avenues for more effective therapy for older patients with melanoma.Significance:These data shed light on the mechanochemical interactions that occur between aged skin, tumor, and immune cell populations, which may affect tumor metastasis and immune cell infiltration, with implications for the efficacy of current therapies for melanoma.See related commentary by Marie and Merlino, p. 19.This article is highlighted in the In This Issue feature, p. 1
Testing an agent-based model of language choice on sociolinguistic survey data
Authors: Karjus Andres , Ehala Martin 
Published: October 2018

Abstract
The paper outlines an agent-based model for language choice in multilingual communities and tests its performance on samples of data drawn from a large-scale sociolinguistic survey carried out in Estonia. While previous research in the field of language competition has focused on diachronic applications, utilizing rather abstract models of uniform speakers, we aim to model synchronic language competition among more realistic, data-based agents. We hypothesized that a reasonably parametrized simulation of interactions between agents endowed with interaction principles grounded in sociolinguistic research would give rise to a network structure resembling real-world social networks, and that the distribution of languages used in the model would resemble their actual usage distribution. The simulation was reasonably successful in replicating the real-world scenarios, while further analysis revealed that the model parameters differ in importance between samples. We conclude that such variation should be considered in parametrizing future language choice and competition models.
100 Years of Progress in Tropical Cyclone Research
Authors: Emanuel Kerry 
Published: October 2018

AbstractA century ago, meteorologists regarded tropical cyclones as shallow vortices, extending upward only a few kilometers into the troposphere, and nothing was known about their physics save that convection was somehow involved. As recently as 1938, a major hurricane struck the densely populated northeastern United States with no warning whatsoever, killing hundreds. In the time since the American Meteorological Society was founded, however, tropical cyclone research blossomed into an endeavor of great breadth and depth, encompassing fields ranging from atmospheric and oceanic dynamics to biogeochemistry, and the precision and scope of forecasts and warnings have achieved a level of success that would have been regarded as impossible only a few decades ago. This chapter attempts to document the extraordinary progress in tropical cyclone research over the last century and to suggest some avenues for productive research over the next one.
Winter Storm Conditions Leading to Excessive Runoff above California’s Oroville Dam during January and February 2017
Authors: White Allen B. , Moore Benjamin J. , Gottas Daniel J. , Neiman Paul J. 
Published: October 2018

AbstractDuring winter 2016/17, California experienced numerous heavy precipitation events linked to land-falling atmospheric rivers (ARs) that filled reservoirs and ended a severe, multiyear drought. These events also caused floods, mudslides, and debris flows, resulting in major socioeconomic disruptions. During 2–11 February 2017, persistent heavy precipitation in the northern Sierra Nevada culminated in a rapid increase in the water level on Lake Oroville, necessitating the activation of an emergency spillway for the first time since the Oroville Dam was installed and forcing the evacuation of 188,000 people. The precipitation, which mostly fell as rain due to elevated freezing levels, was focused on the western slope of the Sierra Nevada in connection with orographic forcing linked to two successive ARs. Heavy rain fell on saturated soils and a snowpack produced by antecedent storms and thereby resulted in excessive runoff into Lake Oroville that led to a damaged spillway and complicated reservoir operations.