bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats
Authors: Kononoff Jenni , Kallupi Marsida , Kimbrough Adam , Conlisk Dana , de Guglielmo Giordano , George Olivier 
Published: June 2018

AbstractGPR139 is an orphan G protein-coupled receptor (GPCR) that is expressed mainly in the brain, with the highest expression in the medial habenula. The modulation of GPR139 receptor function has been hypothesized to be beneficial in the treatment of some mental disorders, but behavioral studies have not yet provided causal evidence of the role of GPR139 in brain dysfunction. Because of the high expression of GPR139 in the habenula, a critical brain region in addiction, we hypothesized that GPR139 may play role in alcohol dependence. Thus, we tested the effect of GPR139 receptor activation using the selective, brain-penetrant receptor agonist JNJ-63533054 on addiction-like behaviors in alcohol-dependent male rats. Systemic administration of JNJ-63533054 (30 mg/kg but not 10 mg/kg, p.o.) reversed the escalation of alcohol self-administration in alcohol-dependent rats, without affecting water or saccharin intake in dependent rats or alcohol intake in nondependent rats. Moreover, systemic JNJ-63533054 administration decreased withdrawal-induced hyperalgesia, without affecting somatic signs of alcohol withdrawal. Further analysis demonstrated that JNJ-63533054 was effective only in a subgroup of dependent rats that exhibited compulsive-like alcohol drinking. Finally, site-specific microinjection of JNJ-63533054 in the habenula but not interpeduncular nucleus (IPN) reduced both alcohol self-administration and withdrawal-induced hyperalgesia in dependent rats. These results provide robust preclinical evidence that GPR139 receptor activation reverses key addiction-like behaviors in dependent animals, suggest that GPR139 may be a novel target for the treatment of alcohol use disorder, and demonstrate that GPR139 is functionally relevant in regulating mammalian behavior.
Por que as empresas saem de redes? Contribuições para formação, gestão e fortalecimento de redes interorganizacionais
Authors: Klein Leander Luiz , Pereira Breno Augusto Diniz 
Published: June 2018

O objetivo deste trabalho é identificar quais fatores estão relacionados à saída de empresas de redes interorganizacionais. Para consecução do objetivo proposto foram selecionadas sete redes interorganizacionais que tiveram empresas se desligando delas, e por meio de entrevistas com os presidentes destas redes foram coletados os dados para o presente estudo. Como procedimentos de análise dos dados seguiu-se a técnica da análise de conteúdo. Os resultados mostram que um conjunto de fatores está ligado a saída de empresas de redes, dentre eles, a falta de critérios para seleção, a falta de comprometimento e confiança, atitudes oportunistas, custo da rede, o individualismo, o imediatismo por resultados e a falta de alcance dos objetivos. Como conclusão tem-se que, mesmo que sejam claros os benefícios que as empresas podem ter atuando em conjunto, alguns fatores podem tornar negativa a relação custo vs benefícios para os parceiros, que acabam por decidir sair da rede.
Turismo inclusivo para todas las personas. Una apuesta por la diversidad
Authors: Martín Cano Mª Carmen , Luque Serrano Encarnación , De la Fuente Robles Yolanda Mª 
Published: June 2018

El turismo y el ocio son espacios fundamentales en la vida de cualquier persona, y por ende un derecho universal reconocido, como así queda reflejado en la Ley 51/2003, de Igualdad de 0portunidades, No Discriminación y Accesibilidad Universal de las Personas con Discapacidad. En este sentido, uno de los aspectos a trabajar en una sociedad avanzada es la accesibilidad al ocio y a la cultura para todas las personas. Cada vez son más las personas con discapacidad o diversidad funcional que demandan la posibilidad de ocupar su sitio en la actividad turística, y a las cuales se les debe garantizar este derecho. Por ello, en este trabajo lo que se pretende es analizar la situación actual y las posibles líneas de intervención en esta materia, concretamente en el turismo inclusivo para las personas con discapacidad o dificultad intelectual. A pesar de los avances que se están consiguiendo, no podemos obviar que este colectivo encuentra aún muchos problemas para hacer efectivo el derecho de acceder a un turismo de calidad. Así mismo se analizan los beneficios que el turismo aporta a todas las personas en general y a las personas con diversidad funcional en particular y, en consecuencia, el porqué de la necesidad del “Turismo para Todas las Personas” o “Turismo Inclusivo”.
Analytical revisit to basics helps reduce unnecessary CT scan in children with abdominal trauma: A single institution experience
Authors: Khan Rizwan A. , Hazique Mohd , Wahab Shagufta 
Published: June 2018

Introduction. CT scan is regarded as the investigation choice for accurate depiction of blunt abdominal injuries in children and is considered as an inevitable tool in the armamentarium of the clinician before deciding for conservative management of these children. However over dependence on CT scan puts the patient to many disadvantages.
The aim of this study to devise stratification criteria for the children with blunt abdominal injury and advise CT scan to the children only who really require it.
Material and methods. All the children with blunt abdominal injury were studied prospectively over a period of two years. These children underwent clinical, biochemical and ultrasonographic assessment at presentation followed by CT abdomen. Efficacy of predefined clinical, biochemical and ultrasonographic parameters was compared with CT scan to triage the children with intra abdominal injury.
Results. A total of 84 children were registered in the study based on final diagnosis of presence or absence of intra abdominal injury the children were divided in two groups. These groups were then compared for various clinical, laboratory and ultrasonographic parameters to predict intra abdominal injury. The children having isolated abdominal injury, tenderness, raised AST, ALT and amylase and free fluid on ultrasonography were found to have more chances of intrabdominal injury (p < 0.001). These parameters were the most sensitive parameters to predict intra abdominal injury and the cumulative sensitivity of these parameters was 99.7%. The CT abdomen was negative in 74.7% of the patients.
Conclusion. Due to high negative rate of CT abdomen in children with abdominal trauma, its use as first line imaging investigation is questionable in all the children with abdominal trauma. We suggest that by utilizing clinical, biochemical and ultrasonographic parameters, the children at risk of intra abdominal injuries can identified with almost 100% accuracy mandating the use of CT scan only in these children.
Results of treatment of children with femoral neck fractures
Authors: Bortulev Pavel I. , Baskov Vladimir E. , Barsukov Dmitry B. , Pozdnikin Ivan Y. , Ovsyankin Anatoliy V. , Drozdetsky Alexey P. , Bortuleva Oksana V. , Baskaeva Tamila V. , Kostomarova Ekaterina A. 
Published: June 2018

Introduction. Femoral fractures in children remain a topical problem because of the risk and frequency of severe complications, such as aseptic necrosis of the femoral head that causes deforming coxarthrosis and early disabilities. This type of injury accounts for approximately 1% of all skeletal bone fractures in childhood. In 80% of the cases, the cause of femoral neck fracture is severe trauma, but in 15% of patients, the fracture occurs despite inadequate trauma during physiologically normal activity of the child. With femoral neck fractures without stable osteosynthesis, consolidation of bone fragments occurs extremely rarely, and a long period of immobilization during conservative treatment is accompanied by a risk of complications caused by hypodynamia.
Aim. To conduct a retrospective analysis of the results of surgical treatment of different types of fracture of the femoral neck in children.
Materials and methods. We analyzed surgical treatment results of 5 children aged 10 to 17 years (4 boys, 1 girl) with different types of femoral neck fractures according to the Delbet and Colonna classification. The cause of the fractures in all 5 children was high-energy trauma. All patients, depending on the type of fracture, underwent a closed repositioning with osteosynthesis of the fragments using metal constructions (cannulated screws, DHS plate). Follow-up observations were performed ≤7 years after the surgical treatment.
Results. Restoration of the hip joint function, absence of pain syndrome, absence of complications, and complete social adaptation was achieved in all cases.
Conclusion. Femoral neck fractures are subject to immediate surgical treatment because there is a high risk of aseptic necrosis of the head of the femur. With the correct technical performance, it is possible to achieve stable, positive, functional, and radiologic long-term results.
Congenital contracture of the iliotibial tract: a case report
Authors: Garkavenko Yuriy E. , Krasnogorskiy Ivan N. , Dolgiev Bahauddin H. 
Published: June 2018

Introduction. Congenital contracture of the iliotibial tract is a rather rare pathology that causes difficulties in diagnosing and planning treatment activities. The lack of a clear idea of the causes of the disease has led to disagreement in the interpretation of the diagnosis in patients with this pathology. In the Russian-language literature, this disease is referred to as idiopathic extension and abduction contracture of a hip joint or idiopathic contracture of the dorsal gluteal muscle (a congenital contracture of the tendons of the dorsal gluteal muscles), whereas the English-language literature more often highlights congenital or idiopathic contracture of the dorsal gluteal muscles.
Clinical сase. The results of treatment of a 6-year-old child with congenital contracture of the iliotibial tract is presented. The child exhibited lameness when walking first started, but the correct diagnosis was not established. Clinically, along with the limitation of adduction and extension in the hip joint and an induration of the soft tissue along the external surface of the right thigh, the pelvis was skewed, and there was shortening of the right lower limb and a valgus deformity of diaphysis of the right femoral bone. Ultrasonographic and magnetic resonance imaging indicated the presence of a fibrous bridle over the outer surface of the right thigh. The fibrous bridle was excised for 15 cm, and a temporary hemiepiphysiodesis of the medial portion of the distal growth zone of the right femur was performed.
Results and discussion. At the 1-year control examination, the patient did not present any complaints. There was no relapse of the contracture. According to X-ray study results, correction of the valgus deformity of the right femur was achieved, and the metal structures were removed. Despite the more frequent extension and abduction direction of the contracture of the iliotibial tract indicated by most authors, the direction and severity apparently may depend on the predominant zone of fibrous degeneration of the muscle groups. Additionally, with the predominant lesion of the dorsal gluteal muscle, a more pronounced extension component can be expected, whereas with the predominant lesion of the musculus tensor fasciae latae, a flexion component can be expected and was observed in our patient.
A study to assess the nutritional status of children with cleft lip and/or cleft palate and its correlation with breast feeding at a tertiary health care centre
Authors: Sampagar Abhilasha , Lakhkar Bhavana , Sampagar Ashok , Wagha Jayanth 
Published: June 2018

Background: Cleft lip with or without cleft palate is one of the most common congenital anomalies. In 2008, the World Health Organization included cleft lip and palate in their Global Burden of Disease initiative. The incidence of cleft lip and palate in India is enormous: one in 781 live births. The growth of children with these deformities is often impaired in comparison to healthy children. Several studies describe a growth lag in either weight or height of cleft children. The objective of the study was to observe the nutritional status of children with cleft lip and/or cleft palate and its correlation with breastfeeding.Methods: A cross sectional study was conducted at Department of Pediatrics, AVBRH Sawangi (Meghe), Wardha for the period of two years from August 2010 to March 2012. All children below 15 years with cleft lip and/or palate admitted in the pediatric ward, NICU or postnatal ward were included in the study. A Total of 200 children were included in the study and analyzed.Results: Male to female ratio was 1.4:1. The commonest type of defect was both the defects present together (62%) which was significantly more than individual defects (א2=23.98, p<0.0001). It was followed by isolated cleft lip (25.5%) and isolated cleft palate (12.5%). Malnutrition was more common in children who were deprived of breast milk (χ2=22.61, Significant). Significantly more children (69.6%) below the age group of 5 yrs were malnourished. (χ2=16. Significant).Conclusions: Our results confirm that, malnutrition is more prevalent in children with orofacial clefts. Lack of breast feeding is a significant contributor to severe malnutrition and recurrent infections in these children.
Clinical profile and neuropsychological assessment of childhood absence epilepsy: a descriptive study
Authors: K. Vindhiya , V. Viswanathan , Balaji Padma 
Published: June 2018

Background: The objectives of the study was to observe the clinical profile and neuropsychological assessment of childhood absence epilepsy.Methods: Children attending Neurology Department of tertiary care hospital diagnosed with Childhood Absence Epilepsy underwent validated structured proforma. Neuropsychological assessment included IQ, Behaviour and learning disability. Comparison was made between group with mono and dual therapy.Results: Number of children studied was 29 with mean age of 6.24years. 20 (68.9%) children were treated with Sodium Valproate. 9 (31.1%) required add on therapy with Lamotrigine. Seizures were well controlled in all children. Mean IQ derived was 101.6 which mean average IQ. Mean CBCL was 25.1 indicating increased behavior problems. There was significant co morbidity like Inattentiveness in 18 (62.1%), Inadequate language ability in 14 (48.3%), Inadequate arithmetic ability in 12 (41.4%) and visual memory was Inadequate in 9 (31%).Conclusions: Though Children with Absence Epilepsy has average or above average IQ, it is associated with significant co-morbidity which if addressed early can improve the long-term outcome. IQ and behavior has statistically significant association with the numbers of drugs.
Lysistrata, Praxagora and Other Women of Aristophanes: a Political, Literary and Current Issue
Authors: Ramos da Silva Francisco Alison , Martins Vieira Francisco Jacson 
Published: June 2018

Abstract: this text provides an overview of the female parts of Aristophanes. In Lysístrata (411 a. C.), Thesmophoriazusae (411 a. C.), and The Women in Parliament, (393 or 392 a. C.), the poet discusses issues of profound interest political and social according to the look of the women who make up at least one choir in each of these three works. With the exception of the second comedy, in that order given just now, the first and third are comedies in which a woman appears as main character: Lysístrata and Praxagora, respectively. Given the state of classical Athens, when the aristophanic´s texts were staged in the Theatre of Dionysus, it is vital to ask what the poet wanted to discuss political and literary´ matters in the light of gender issues. This would place him in a category of intellectual and revolutionary prime, taking his work beyond the immediate of his actuality. Lisístrata, Praxágora e Outras Mulheres de Aristófanes: uma Questão Política, Literária e Atual Resumo: este texto oferece um panorama das peças femininas de Aristófanes. Em Lisístrata (411 a. C.), Tesmoforiantes (411 a. C.) e As Mulheres no Parlamento, (393 ou 392 a. C.), o poeta discute problemas de profundo interesse político e social segundo o olhar das mulheres que formam pelo menos um coro em cada uma dessas três obras. Com exceção da segunda comédia, nessa ordem dada há pouco, a primeira e a terceira são comédias em que uma mulher surge como personagem principal: Lisístrata e Praxágora, respectivamente. Dada a situação da Atenas clássica, quando os textos aristofânicos eram encenados no Teatro de Dioniso, é vital que se questione o que pretendia o poeta ao discutir assuntos políticos e literários à luz de questões de gênero. Isso o colocaria numa categoria intelectual e revolucionária privilegiada, levando sua obra para além da realidade imediata de sua atualidade. Palavras-chave: Mulheres; Aristófanes; comédia; atualidade política; literatura.
Celery herb essential oil in the formulation of anti-dandruff hair tonic against Pityrosporum ovale
Authors: Ningrum Riska Surya , Prasetyo Antonius Budi , Kristanti Alfinda Novi 
Published: June 2018

Abstract Essential oil from Apium graveolens (celery), a species belonged to Apiceae, was isolated, identified, and tested its activity against fungi Pityrosporum ovale, fungi that cause dandruff problem. Essential oil isolation was conducted by steam distillation. The identification with GC-MS showed that the major compound of celery essential oil was 3-isobutylidenphalide. The anti-fungal activity test was performed using pure celery oil and celery oil added with virgin coconut oil (VCO) and paraffin oil that are usually used as components in hair tonic formulation. The bioactivity test showed that celery oil, whether in pure form or in hair tonic formulation exhibited excellent growth inhibition activity of Pityrosporum ovale Keywords : essential oil, celery, Apium graveolens, hair tonic, anti-dandruff, Pityrosporum ovale
OPTIMASI JENIS DAN KADAR SUMBER NITROGEN SERTA pH MEDIUM UNTUK PRODUKSI PROTEASE DARI ISOLAT HTcUM6.2.2 DARI TAUCO SURABAYA
Authors: Rahayu Monika , Susanti Evi 
Published: June 2018

AbstrakPenelitian ini bertujuan untuk mengetahui sumber nitrogen, kadar sumber nitrogen dan pH optimum untuk produksi protease isolat HTcUM6.2.2. Penelitian ini merupakan penelitian eksperimental laboratoris menggunakan Rancangan Acak Lengkap (RAL) satu faktorial masing-masing yaitu jenis, kadar sumber nitrogen, serta pH medium dengan tahap penelitian terdiri dari peremajaan, validasi kemurnian isolat HTcUM6.2.2, produksi ekstrak kasar protease isolat HTcUM6.2.2, uji aktivitas protease. Hasil penelitian menunjukkan sumber nitrogen optimum untuk menghasilkan protease dari isolat HTcUM6.2.2 adalah susu skim dan limbah cair tahu. Kadar limbah cair tahu optimum untuk produksi protease dari isolat HTcUM6.2.2 sebesar 10 %. Produksi protease cukup tinggi dan relatif konstan antara pH 6 sampai 8. Aktivitas protease tertinggi sebesar 0,817 U/ml dicapai dengan penggunaan 10 % limbah cair tahu pada medium produksi, pH = 7 selama 3 hari. Kata kunci: protease, tauco, isolat, nitrogen, limbah cair tahu AbstractThis study aims to determine the optimum of the nitrogen source, percentage of nitrogen source and pH for the production of protease from isolate HTcUM6.2.2. This research is a laboratory experimental with a research stage comprising inoculation and validation of the purity of the isolates HTcUM6.2.2, production of crude extract of protease to determine source of nitrogen, percentage of nitrogen source and pH optimum, determination of protease activity. The results showed that the optimum source of nitrogen to produce proteases from the HTcUM6.2.2 isolate was skim milk and tofu wastewater. Percentage of nitrogen source optimum to produce protease of HTcUM6.2.2 isolate was 10 % of tofu wastewater. Protease production is relatively high and constantance at pH 6 to 8. The highest protease activity was achieved by the use of 10 % tofu wastewater at production medium, pH = 7 for 3 days was 0,817 U/mL. The keywords: protease, tauco, isolate, nitrogen, tofu wastewater
Flavon Compound from The Ethyl Acetate Extract of The Stem of Supit (Tetracera indica Merr.)
Authors: Muharni Muharni , Elfita Elfita , Adillah Riska , Yohandini Heni , Julinar Julinar 
Published: June 2018

Tetracera indica Merr. in Musi Banyuasin, is one of the traditional medicine used by the community for the treatment of kidney stone disease and gout, but this claim is not recorded in the treatment of kidney stones and gout in Indonesia. In this study, isolation of antioxidant compound from ethyl acetate extracts of supit (Tetracera indica) was done. The isolation was carried out through step gradient polarity extraction, and separated and purified by chromatography technique. The determination of the structure of the isolated compound was performed by spectroscopy method including UV, IR, and NMR 1D and 2D, and antoxidant activity was determined by DPPH method. An active antioxidant compound was isolated from ethyl acetate extract in form of yellow solid (15 mg). Based on spectroscopic analysis the isolated compound was 5,8-dihydroxy-7-methoxyflavone. The compound showed strong antioxidant activity (IC50 8.25 μg/mL) higher than standard ascorbic acid (IC50 11.3 μg/mL). This data concluded that efficacy of supit (Tetracera indica) for the treatment related to antioxidant activity (uric acid) is proven by the identification of one antioxidant compound of this plant.
YARGI KARARLARI IŞIĞINDA TANINMIŞ MARKA İTİRAZINDA HAKLI SEBEP KAVRAMI
Authors: OĞUZ Arzu 
Published: June 2018

Yeni Sınai Mülkiyet Kanunu (SMK) md. 6/5: “tescil
edilmiş veya tescil için başvurusu daha önceki tarihte yapılmış bir markanın,
Türkiye’de ulaştığı tanınmışlık düzeyi nedeniyle haksız bir yararın
sağlanabileceği, markanın itibarının zarar görebileceği veya ayırt edici
karakterini zedelenebileceği hallerde, aynı ya da benzer markanın tescil
başvurusu haklı bir nedene dayanma hali saklı kalmak kaydıyla, başvurunun aynı,
benzer veya farklı mal veya hizmetlerde yapılmış olmasına bakılmaksızın önceki
tarihli marka sahibinin itirazı üzerine reddedilir” hükmüne yer vermiştir.
Bu koşulun gerçekleşebilmesi için öncelikle eskiden tescil edilmiş ya da
tescili için başvurulmuş markanın, Türkiye’de belli bir tanınmışlık düzeyine
yükselmesi aranmaktadır.

Hükme göre, söz konusu nispi tescil engelinin
uygulanabilmesi için; başvuru konusu marka, Türkiye’de tanınmışlık düzeyine
ulaşmış marka ile aynı ya da benzer olmalıdır. Ayrıca sonraki tarihli başvuru
konusu işaretin tescili, toplumda tanınmışlık düzeyine ulaşmış markanın ününden
haksız yarar sağlanmasına, onun itibarına zarar vermesine veya onun ayırt edici
karakterinin zedelenmesine neden olmalıdır.

Önceki düzenleme 556 sayılı
KHK md. 8/4’den farklı olarak SMK, sonraki tarihli başvuru sahibine başvuru
yapma konusunda “haklı sebep” ileri sürme imkânı tanımış, ayrıca şartların
sağlanması halinde anılan korumanın, mal/hizmetlerin aynı, benzer ya da ayırt
edilemeyecek kadar benzer olmasına bakılmaksızın uygulanabileceğini
öngörmüştür. Haklı sebep hükmün istisnasını oluşturmaktadır. Buna göre,
tanınmış marka ile aynı ya da benzer bir işaret, tanınmış markanın tescilli
olduğu mal ve hizmetlere benzer mal ve hizmetler için kullanılsa bile “haklı
sebep” varsa, tanınmış marka sahibi bu kullanıma katlanmak mecburiyetindedir.
Ciddi bir istisna olarak marka hukuku sistemimize getirilen “haklı sebep”
kavramının, özellikle yabancı mahkeme kararları ışığında hangi ölçütlere göre
uygulanması gerektiği hususu önem kazanmaktadır.