bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of vibration sense by frequency characteristics of impact vibration for residential floor
Authors: Tomita Ryuta , Inoue Katsuo 
Published: May 2018

AbstractIn this research, we examined the effects that the frequency characteristics of impact vibration in a residential floor have on the vibration sense of humans. We obtained the following results: (i) a frequency of 30 Hz or more affects the vibration sense of humans; (ii) the influence of the broadband waveform on the vibration sense of humans is larger than that of the narrowband waveform; and (iii) for the broadband waveform but not for the narrowband, even a small vibration of approximately 4‐5 dB is perceptible.
Development of a robust MRI fiducial system for automated fusion of MR‐US abdominal images
Authors: Favazza Christopher P. , Gorny Krzysztof R. , Callstrom Matthew R. , Kurup Anil N. , Washburn Michael , Trester Pamela S. , Fowler Charles L. , Hangiandreou Nicholas J. 
Published: May 2018

AbstractWe present the development of a two‐component magnetic resonance (MR) fiducial system, that is, a fiducial marker device combined with an auto‐segmentation algorithm, designed to be paired with existing ultrasound probe tracking and image fusion technology to automatically fuse MR and ultrasound (US) images. The fiducial device consisted of four ~6.4 mL cylindrical wells filled with 1 g/L copper sulfate solution. The algorithm was designed to automatically segment the device in clinical abdominal MR images. The algorithm's detection rate and repeatability were investigated through a phantom study and in human volunteers. The detection rate was 100% in all phantom and human images. The center‐of‐mass of the fiducial device was robustly identified with maximum variations of 2.9 mm in position and 0.9° in angular orientation. In volunteer images, average differences between algorithm‐measured inter‐marker spacings and actual separation distances were 0.53 ± 0.36 mm. “Proof‐of‐concept” automatic MR‐US fusions were conducted with sets of images from both a phantom and volunteer using a commercial prototype system, which was built based on the above findings. Image fusion accuracy was measured to be within 5 mm for breath‐hold scanning. These results demonstrate the capability of this approach to automatically fuse US and MR images acquired across a wide range of clinical abdominal pulse sequences.
Density scaling of phantom materials for a 3D dose verification system
Authors: Tani Kensuke , Fujita Yukio , Wakita Akihisa , Miyasaka Ryohei , Uehara Ryuzo , Kodama Takumi , Suzuki Yuya , Aikawa Ako , Mizuno Norifumi , Kawamori Jiro , Saitoh Hidetoshi 
Published: May 2018

AbstractIn this study, the optimum density scaling factors of phantom materials for a commercially available three‐dimensional (3D) dose verification system (Delta4) were investigated in order to improve the accuracy of the calculated dose distributions in the phantom materials. At field sizes of 10 × 10 and 5 × 5 cm2 with the same geometry, tissue‐phantom ratios (TPRs) in water, polymethyl methacrylate (PMMA), and Plastic Water Diagnostic Therapy (PWDT) were measured, and TPRs in various density scaling factors of water were calculated by Monte Carlo simulation, Adaptive Convolve (AdC, Pinnacle3), Collapsed Cone Convolution (CCC, RayStation), and AcurosXB (AXB, Eclipse). Effective linear attenuation coefficients (μeff) were obtained from the TPRs. The ratios of μeff in phantom and water ((μeff)pl,water) were compared between the measurements and calculations. For each phantom material, the density scaling factor proposed in this study (DSF) was set to be the value providing a match between the calculated and measured (μeff)pl,water. The optimum density scaling factor was verified through the comparison of the dose distributions measured by Delta4 and calculated with three different density scaling factors: the nominal physical density (PD), nominal relative electron density (ED), and DSF. Three plans were used for the verifications: a static field of 10 × 10 cm2 and two intensity modulated radiation therapy (IMRT) treatment plans. DSF were determined to be 1.13 for PMMA and 0.98 for PWDT. DSF for PMMA showed good agreement for AdC and CCC with 6 MV x ray, and AdC for 10 MV x ray. DSF for PWDT showed good agreement regardless of the dose calculation algorithms and x‐ray energy. DSF can be considered one of the references for the density scaling factor of Delta4 phantom materials and may help improve the accuracy of the IMRT dose verification using Delta4.
Improved Stable Indocyanine Green (ICG)‐Mediated Cancer Optotheranostics with Naturalized Hepatitis B Core Particles
Authors: Shan Wenjun , Chen Ronghe , Zhang Qiang , Zhao Jie , Chen Binbin , Zhou Xi , Ye Shefang , Bi Shengli , Nie Liming , Ren Lei 
Published: May 2018

AbstractIn recent years, hepatitis B core protein virus‐like particle (HBc VLP) is an impressive biomaterial, which has attracted considerable attention due to favorable properties such as structural stability, high uptake efficiency, and biocompatibility in biomedical applications. Heretofore, only a few attempts have been made to apply it in physical, chemical, and biological therapy for cancer. In this study, a tumor‐targeting RGD‐HBc VLP is first fabricated through genetic engineering. For image‐guided cancer phototherapy, indocyanine green (ICG) is loaded into RGD‐HBc VLP via a disassembly/reassembly pathway and electrostatic attraction with high efficiency. The self‐assembled stable RGD‐HBc VLP significantly improves body retention (fourfold longer), aqueous stability, and target specificity of ICG. Remarkably, these positive reformations promote more accurate and sensitive imaging of U87MG tumor, as well as prolonged tumor destruction in comparison with free ICG. Moreover, the photothermal and photodynamic effect on tumors are quantitatively differentiated by multiple linear regression analysis. Overall, less‐potent medicinal ICG can be perfectly rescued by bioengineered HBc VLP to realize enhanced cancer optotheranostics.
Superfast Electrodeposition of Newly Developed RuCo2O4 Nanobelts over Low‐Cost Stainless Steel Mesh for High‐Performance Aqueous Supercapacitor
Authors: Chodankar Nilesh R. , Dubal Deepak P. , Ji Su‐Hyeon , Kim Do‐Heyoung 
Published: May 2018

AbstractThe superfast (≈30 min) and template‐free electrochemical approach is developed to prepare the unique nanobelts‐architectured RuCo2O4 thin films over the stainless steel mesh substrates. The vertically aligned and interconnected RuCo2O4 nanobelts present sufficient interspace to provide more electroactive sites and shorten the diffusion path for electrolyte ions. Owing to their unique nanostructure and higher electrical conductivity, the RuCo2O4 nanobelts exhibit excellent electrochemical features, including a specific capacitance of 1447 F g−1, and excellent electrochemical stability (82.25% retention over 16 000 cycles). Additional electrochemical kinetic analysis is carried out to confirm whether the energy storage in the RuCo2O4 electrode is limited by solid‐state diffusion or whether it is surface‐controlled capacitive. More importantly, the comprehensive cycling analysis is performed to identify the factors responsible for capacity reduction upon long‐term cycling. The RuCo2O4 nanobelts based symmetric supercapacitor shows good supercapacitive characteristics and excellent specific capacitance (276 F g−1 at 2.5 A g−1) and specific energy (30 Wh kg−1 at a specific power of 200 W kg−1), which are superior to those of recently reported symmetric and asymmetric supercapacitor devices. This work presents a new electrode material for fabricating advanced high energy supercapacitor for different applications.
Chemical Vapor Deposition of 2D Vanadium Disulfide and Diselenide and Raman Characterization of the Phase Transitions
Authors: Hossain Mongur , Wu Juanxia , Wen Wen , Liu Haining , Wang Xinsheng , Xie Liming 
Published: May 2018

Abstract2D metallic vanadium dichalcogenides (VX2) have renewed interest due to their unique physical properties and potential applications as high‐performance functional nanomaterials. Herein, the synthesis and phase transitions of 2D metallic VX2 are investigated. The synthesis is done by chemical vapor deposition using hexagonal boron nitride and mica as substrates. High‐quality VX2 flakes with sub‐10 nm thickness are obtained and characterized by transmission electron microscopy. Temperature‐dependent Raman characterization between 330 and 5 K is conducted and remarkable changes of Raman modes at around 150 K for VS2 flakes and 110 K for VSe2 flakes are revealed, indicating charge density wave phase transitions. Temperature‐dependent electrical measurements have also supported the phase transitions observed in Raman characterization.
Enantioselective Synthesis of Tropanes via [3+3] Annulation of Cyclic Azomethine Ylides with Substituted 2‐Vinylindoles and 2‐Vinylpyrroles
Authors: Zheng Xing , Yang Wu‐Lin , Liu Yang‐Zi , Wu Shu‐Xiao , Deng Wei‐Ping 
Published: May 2018

AbstractA novel strategy for constructing tropanes via [3+3] annulation of cyclic azomethine ylides with substituted 2‐vinylindoles and 2‐vinylpyrroles in the presence of in‐house Cu(II)/N,O‐ligand complex has been developed. The reaction was achieved via a tandem copper(II)‐catalyzed Michael addition/BF3 ⋅ Et2O promoted intramolecular aza‐Friedel‐Crafts reaction of indoles or pyrroles with non‐activated ketimines, providing indole or pyrrole‐annulated tropanes in high yields (up to 87%) and excellent stereoselectivities (>99:1 dr in all cases, up to >99% ee).magnified image
Carbon Felt Monoliths Coated with a Highly Hydrophobic Mesoporous Carbon Phase for the Continuous Oil Sorption/Filtration from Water
Authors: Ba Housseinou , Liu Yuefeng , Wang Wei , Duong‐Viet Cuong , Papaefthimiou Vasiliki , Nguyen‐Dinh Lam , Tuci Giulia , Giambastiani Giuliano , Pham‐Huu Cuong 
Published: May 2018

AbstractThe recovery of oils and organic compounds is a key challenge in wastewater purification processes. Herein the authors describe a straightforward and easy‐to‐scale‐up strategy for the fabrication of lightweight and highly hydrophobic composites with superior mechanical strength, through the coating of commercial carbon felt (CF) with a thin mesoporous carbon phase (MC). Composites are prepared by a dip‐coating method starting from CF foams to be soaked in a water/ethanol solution of food‐grade components before undergoing two successive thermal treatments. They exhibit an extremely high efficiency and complete reusability in the recovery of oils and organic compounds from wastewaters both as classical absorbents under batch conditions or filters under continuum separation mode. Notably, the electrical conductivity/resistivity of composites has allowed their application to the recovery of water floating waxy organic residues. Indeed, absorbents can be heated up by the passage of an electrical current (DC) thus allowing semi‐solid organic pollutants to be melted and absorbed by the hydrophobic composite without sorbent fouling or deactivation. The outlined strategy towards cheap and scalable lightweight hydrophobic materials for wastewater cleaning and environmental remediation from oil spilling, is a highly attractive technology that offers concrete hints to the exploitation of these composites at industrial level.
Confined Ultrathin Pd‐Ce Nanowires with Outstanding Moisture and SO2 Tolerance in Methane Combustion
Authors: Peng Honggen , Rao Cheng , Zhang Ning , Wang Xiang , Liu Wenming , Mao Wenting , Han Lu , Zhang Pengfei , Dai Sheng 
Published: May 2018

AbstractAn efficient strategy (enhanced metal oxide interaction and core–shell confinement to inhibit the sintering of noble metal) is presented confined ultrathin Pd‐CeOx nanowire (2.4 nm) catalysts for methane combustion, which enable CH4 total oxidation at a low temperature of 350 °C, much lower than that of a commercial Pd/Al2O3 catalyst (425 °C). Importantly, unexpected stability was observed even under harsh conditions (800 °C, water vapor, and SO2), owing to the confinement and shielding effect of the porous silica shell together with the promotion of CeO2. Pd‐CeOx solid solution nanowires (Pd‐Ce NW) as cores and porous silica as shells (Pd‐CeNW@SiO2) were rationally prepared by a facile and direct self‐assembly strategy for the first time. This strategy is expected to inspire more active and stable catalysts for use under severe conditions (vehicle emissions control, reforming, and water–gas shift reaction).
Simultaneous Stabilization of Potassium Metal and Superoxide in K–O2 Batteries on the Basis of Electrolyte Reactivity
Authors: Xiao Neng , Gourdin Gerald , Wu Yiying 
Published: May 2018

AbstractIn superoxide batteries based on O2/O2− redox chemistry, identifying an electrolyte to stabilize both the alkali metal and its superoxide remains challenging owing to their reactivity towards the electrolyte components. Bis(fluorosulfonyl)imide (FSI−) has been recognized as a “magic anion” for passivating alkali metals. The KFSI–dimethoxyethane electrolyte passivates the potassium metal anode by cleavage of S−F bonds and the formation of a KF‐rich solid–electrolyte interphase (SEI). However, the KFSI salt is chemically unstable owing to nucleophilic attack by superoxide and/or hydroxide species. On the other hand, potassium bis(trifluorosulfonyl)imide (KTFSI) is stable to KO2, but results in mossy potassium deposits and irreversible plating and stripping. To circumvent this dilemma, we developed an artificial SEI for the metal anode and thus long‐cycle‐life K–O2 batteries. This study will guide the development of stable electrolytes and artificial SEIs for metal–O2 batteries.
Glycoinformatics: Bridging Isolated Islands in the Sea of Data
Authors: Egorova Ksenia S. , Toukach Philip V. 
Published: May 2018

AbstractGlycoinformatics is an actively developing scientific discipline, which provides scientists with the means of access to the data on natural glycans and with various tools of their processing. However, the informatization of glycomics has a long way to go before catching up with genomics and proteomics. In this Viewpoint, we review the current situation in glycoinformatics and discuss its achievements and shortcomings, emphasizing the major drawbacks: the lack of recognized standards, protocols, data indices and tools, and the informational isolation of the existing projects. We reiterate possible solutions of the persistent issues and describe our vision of an ideal glycoinformatics project.
A Regio‐ and Diastereoselective Anodic Aryl–Aryl Coupling in the Biomimetic Total Synthesis of (−)‐Thebaine
Authors: Lipp Alexander , Ferenc Dorota , Gütz Christoph , Geffe Mario , Vierengel Nina , Schollmeyer Dieter , Schäfer Hans J. , Waldvogel Siegfried R. , Opatz Till 
Published: May 2018

AbstractThe biosynthesis of thebaine is based on the regioselective, intramolecular, oxidative coupling of (R)‐reticuline. For decades, chemists have sought to mimic this coupling by using stoichiometric oxidants. However, all approaches to date have suffered from low yields or the formation of undesired regioisomers. Electrochemistry would represent a sustainable alternative in this respect but all attempts to accomplish an electrochemical synthesis of thebaine have failed so far. Herein, a regio‐ and diastereoselective anodic coupling of 3′,4′,5′‐trioxygenated laudanosine derivatives is presented, which finally enables electrochemical access to (−)‐thebaine.
An Unexpected α‐Oxidation of Cyclic Ketones with 1,4‐Benzoquinone by Enol Catalysis
Authors: Shevchenko Grigory A. , Oppelaar Barry , List Benjamin 
Published: May 2018

AbstractThe first direct and asymmetric α‐aryloxylation of cyclic ketones via enol catalysis has been achieved using quinones as the reaction partners. Catalytic amounts of a phosphoric acid promote the exclusive formation of α,α‐disubstituted ketones from the corresponding α‐substituted ketones in good yields and enantioselectivities (up to 96.5:3.5 er). Preliminary mechanistic experiments suggest that this reaction proceeds via a proton‐coupled electron transfer (PCET) followed by radical recombination.
Synthesis of BaFe1‐xNixCuxO3‐δ new ceramic composition as solid oxide fuel cell cathode by microwave‐assisted solid‐state reaction
Authors: Moghaddas Shahab , Maghsoudipour Amir , Ebadzadeh Touradj 
Published: May 2018

AbstractIn this research, new ceramic BaFe0.8Ni0.1Cu0.1O3‐δ powder was synthesized by solid‐state reaction method in conventional and microwave furnaces. Then, characterization, structure, and morphology of the resulting powders were studied. For characterization of synthetic powders, X‐ray diffraction, powder density gas pycnometer method, particle size analysis, scanning electron microscopy, and energy‐dispersive spectroscopy were performed. The results showed that the BaFe0.8Ni0.1Cu0.1O3‐δ powder synthesized in microwave furnace at 1,000 °C without soaking time and in conventional furnace at the same temperature with 12‐hr soaking time. In addition, the X‐ray diffraction results demonstrated that the main peak is shifted to lower angles by substitution iron ions with nickel and copper ions. Furthermore, the crystal structures of powders were hexagonal and tetragonal, and their density were 5.88 and 5.43 g/cm3, respectively, in conventional and microwave furnaces. Finally, the morphology and particle size of the synthesized powders were the same in both furnaces.
Coupling exothermic and endothermic reactions—Application to combined aniline production/methyl‐cyclohexane dehydrogenation
Authors: Javaid Ahtesham , Bildea Costin Sorin 
Published: May 2018

AbstractThe scope of this study is to emphasize the possibility and benefits of direct coupling of exothermic and endothermic reactions. Simultaneous production of aniline by exothermic nitrobenzene hydrogenation and endothermic dehydrogenation of methyl‐cyclohexane to toluene is investigated. Instead of multitubular reactor, the reaction is carried out in an adiabatic reactor eliminating the requirement of complex setup of the hydrogenation reactor. Additionally, large amount of hydrogen needed to avoid reaction runaway is no longer needed. Nonlinear analysis of reactor–separation–recycle shows difficulty in controlling integrated plants where unreacted reactant is recycled. Details of the plant design, obtained by Aspen Plus simulation, are given. The new integrated system is feasible with the benefits of simple reactor and reduce hydrogen requirement. Economic analysis shows that the total annual cost of coupled system is reduced by 20%. The results obtained here are also applicable to other chemical processes of practical relevance.
Bartonella endocarditis in a child with tetralogy of Fallot complicated by PR3‐ANCA positive serology, autoimmune hemolytic anemia, and acute kidney injury
Authors: Williams James M. , Parimi Manoj , Sutherell Jamie 
Published: May 2018

Key Clinical MessageAlthough the role of ANCA in infective endocarditis is unclear, Bartonella henselae has been implicated as the culprit in cases of PR3‐ANCA positive subacute bacterial endocarditis (SBE) with glomerulonephritis. In this case, a Coombs‐positive autoimmune hemolytic anemia and glomerulonephritis accompanied a PR3‐ANCA positive SBE caused by Bartonella henselae.
Ylide Ligands as Building Blocks for Bioactive Group 11 Metal Complexes
Authors: Johnson Alice , Marzo Isabel , Gimeno M. Concepción 
Published: May 2018

AbstractThe reactivity of the phosphonium salt (cyanomethyl)triphenylphosphonium chloride and the ylide (triphenylphosphonio)cyanomethanide towards Group 11 metal complexes is described. Mononuclear neutral gold(I) and gold(III) complexes of the type [AuX{CH(CN)PPh3}] or [AuX3{CH(CN)PPh3}] and cationic derivatives such as [AuL{CH(CN)PPh3}]X have been prepared. Surprisingly, the cationic gold species could only be prepared with ligands with a large steric hindrance, such as bulky NHCs or the JohnPhos phosphine, in contrast to silver and copper derivatives, which have dimeric structures through the coordination of the metal to the cyano group of the ylide of a second complex. Bis(ylide) metal complexes have also been synthesised in which a different structure is observed for the gold complexes compared with the copper and silver complexes. Although gold forms mononuclear species, the silver complex presents a two‐dimensional polymeric structure as a result of further coordination of the silver centre to the nitrogen atoms of cyano groups of further silver complexes. These complexes possess two chiral centres; the gold compound was obtained as a mixture of diastereoisomers, whereas the copper and silver derivatives afford only one diastereoisomer. These compounds were screened for their in vitro cytotoxic activity against the human lung carcinoma cell line (A549). The IC50 values reveal an excellent cytotoxic activity for these metal complexes compared with cisplatin.
Hydroxylamine Derivatives as Nitrogen‐Radical Precursors in Visible‐Light Photochemistry
Authors: Davies Jacob , Morcillo Sara P. , Douglas James J. , Leonori Daniele 
Published: May 2018

AbstractIn recent years, hydroxylamines derivatives have been exploited as nitrogen‐radical precursors in visible‐light photochemistry. Their ability to serve as electrophores in redox chemistry has propelled the development of many novel transformations. Fundamental mechanistic aspects as well as the importance in the preparation of nitrogen‐containing molecules will be highlighted.
Palladium‐Catalyzed Formal [4+2] Cycloaddition of Benzoic and Acrylic Acids with 1,3‐Dienes via C—H Bond Activation: Efficient Access to 3,4‐Dihydroisocoumarin and 5,6‐Dihydrocoumalins
Authors: Sun Youwen , Zhang Guozhu 
Published: May 2018

AbstractWe report a palladium‐catalyzed formal intermolecular [4+2] cycloaddition of benzoic and acrylic acids with 1,3‐dienes including the stock chemicals 1,3‐butadiene and isoprene leading to synthetically useful 3,4‐dihydroisocoumarins and 5,6‐dihydrocoumalins. Stepwise C—H bond cleavage and annulation are likely involved in the reaction pathway. The synthetic potential of the methodology was demonstrated by two short derivatizations and total synthesis of natural product Clausamine B.
A Thorough QT/QTc Study With Laquinimod, a Novel Immunomodulator in Development for Multiple Sclerosis and Huntington Disease
Authors: Spiegelstein Ofer , Mimrod Dorit , Rabinovich Laura , Eyal Eli , Sprenger Craig , Elgart Anna , Samara Emil , Morganroth Joel 
Published: May 2018

AbstractIn this randomized double‐blind study, 4 groups of healthy subjects (50 per arm) participated to evaluate the effect of laquinimod, an oral treatment in development for multiple sclerosis and Huntington disease, on the QTc interval. Subjects received a dose of either 0.6 or 1.2 mg/day laquinimod for 14 days, placebo for 14 days, or 13 days of placebo followed by a dose of 400 mg moxifloxacin on day 14. Continuous 12‐lead electrocardiograms were recorded on day –1 (baseline) and days 14 to 17, and quadruplicate electrocardiograms were extracted at predefined time points. The primary measure was time‐matched change from baseline in individual QTc (QTcI), and an analysis of variance was conducted on the placebo‐corrected change from baseline data (ddQTcI). Pharmacokinetic‐pharmacodynamic and safety assessments were included. Results showed that the upper limits of the 2‐sided 90%CI for ddQTcI for both laquinimod doses were below 10 millisconds at all time points, whereas lower limits for moxifloxacin were above 5 milliseconds. No notable changes in ECG parameters were observed. Pharmacokinetic/pharmacodynamic analysis showed no positive correlation between laquinimod plasma levels and QTcI. In conclusion, laquinimod was not found to affect cardiac repolarization or to cause prolongation of QTcI at doses of 0.6 and 1.2 mg/day.