bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammasome Signaling and Impaired Vascular Health in Psoriasis
Authors: Garshick Michael S. , Barrett Tessa J. , Wechter Todd , Azarchi Sarah , Scher Jose U. , Neimann Andrea , Katz Stuart , Fuentes-Duculan Judilyn , Cannizzaro Maria V. , Jelic Sanja , Fisher Edward A. , Krueger James G. , Berger Jeffrey S. 
Published: February 2019

Objective—
Psoriasis is an inflammatory skin disease which heightens the risk of cardiovascular disease. This study directly investigated vascular endothelial health and systemically altered pathways in psoriasis and matched controls.

Approach and Results—

Twenty patients (mean age, 40 years; 50% male) with active psoriasis and 10 age-, sex-matched controls were recruited. To investigate systemically alerted pathways, a deep sequencing omics approach was applied, including unbiased blood transcriptomic and targeted proteomic analysis. Vascular endothelial health was assessed by transcriptomic profiling of endothelial cells obtained from the brachial veins of recruited participants. Blood transcriptomic profiling identified inflammasome signaling as the highest differentially expressed canonical pathway (
Z
score 1.6;
P
=1×10
-7
) including upregulation of
CASP5
and interleukin (
IL
)
-1β
. Proteomic panels revealed IL-6 as a top differentially expressed cytokine in psoriasis with pathway analysis highlighting
IL-1β
(
Z
score 3.7;
P
=1.02×10
-23
) as an upstream activator of the observed upregulated proteins. Direct profiling of harvested brachial vein endothelial cells demonstrated inflammatory transcript (eg,
IL-1β, CXCL10, VCAM-1, IL-8, CXCL1
,
Lymphotoxin beta
,
ICAM-1
,
COX-2
, and
CCL3
) upregulation between psoriasis versus controls. A linear relationship was seen between differentially expressed endothelial inflammatory transcripts and psoriasis disease severity. IL-6 levels correlated with inflammatory endothelial cell transcripts and whole blood inflammasome-associated transcripts, including
CASP5
and
IL-1β
.

Conclusions—
An unbiased sequencing approach demonstrated the inflammasome as the most differentially altered pathway in psoriasis versus controls. Inflammasome signaling correlated with psoriasis disease severity, circulating IL-6, and proinflammatory endothelial transcripts. These findings help better explain the heightened risk of cardiovascular disease in psoriasis.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT03228017.
Rapid Alteplase Administration Improves Functional Outcomes in Patients With Stroke due to Large Vessel Occlusions
Authors: Goyal Mayank , Almekhlafi Mohammed , Dippel Diederik W. , Campbell Bruce C.V. , Muir Keith , Demchuk Andrew M. , Bracard Serge , Davalos Antoni , Guillemin Francis , Jovin Tudor G. , Menon Bijoy K. , Mitchell Peter J. , Brown Scott , White Philip , Majoie Charles B.L.M. , Saver Jeffrey L. , Hill Michael D. ,   for the HERMES Collaborators
Published: February 2019

Background and Purpose—
We report the relation of onset-to-treatment time and door-to-needle time with functional outcomes and mortality among patients with ischemic stroke with imaging-proven large vessel occlusion treated with intravenous alteplase.

Methods—
Individual patient-level data from the HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials) collaboration were pooled from 7 trials that randomized patients to mechanical thrombectomy added to best medical therapy versus best medical therapy alone. Analysis was restricted to patients who received alteplase directly at the endovascular hospital. The primary outcome was disability defined on the modified Rankin Scale at 3 months.

Results—
Among 601 patients, mean age was 66.0 years (SD, 13.9), 50% were women, and median National Institutes of Health Stroke Scale score was 17. Onset-to-treatment time was median 125 minutes (interquartile range, 90–170). Door-to-treatment time was median 38 minutes (interquartile range, 26–55). Each 60-minute onset-to-treatment time delay was associated with greater disability at 90 days; the odds of functional independence (modified Rankin Scale, 0–2) at 90 days was 0.82 (95% CI, 0.66–1.03). With each 60-minute delay in door-to-needle time; the odds of functional independence was 0.55 (95% CI, 0.37–0.81) at 90 days. The absolute decline in the rate of excellent outcome (modified Rankin Scale, 0–1 at 90 days) was 20.3 per 1000 patients treated per 15-minute delay in door-to-needle time. The adjusted absolute risk difference for a door-to-needle time <30 minutes versus 30 to 60 minutes was 19.3% for independent outcome (number-needed-to-treat ≈5 to gain 1 additional good outcome). Symptomatic intracranial hemorrhage occurred in 3.4% of patients, without a significant time dependency: odds ratio, 0.74 (95% CI, 0.43–1.28).

Conclusions—
Faster intravenous thrombolysis delivery is associated with less disability at 3 months among patients with large vessel occlusion.
The Gulf Stream North Wall: Ageostrophic Circulation and Frontogenesis
Authors: McWilliams James C. , Gula Jonathan , Molemaker M. Jeroen 
Published: February 2019

AbstractEastward zonal jets are common in the ocean and atmosphere, for example, the Gulf Stream and jet stream. They are characterized by atypically strong horizontal velocity, baroclinic vertical structure with an upward flow intensification, large change in the density stratification meridionally across the jet, large-scale meanders around a central latitude, narrow troughs and broad crests, and a sharp and vertically sloping northern (poleward) “wall” defined by horizontal maxima in the lateral gradients of both velocity and density. Measurements and realistic oceanic simulations show these features in the Gulf Stream downstream from its western boundary separation point. A diagnostic theory based on the conservative balance equations is developed to calculate the 3D velocity field associated with the dynamic height field. When applied to an idealized representation of a meandering jet, it explains the spatial structure of the associated ageostrophic secondary circulation around the jet and the positive frontogenetic tendency along the northern wall in the meander sector located upstream from the trough. This provides a basis for understanding why submesoscale instabilities and cross-wall intrusion and streamer events are more prevalent along the sector downstream from the trough and at the crest where there is not such a frontogenetic tendency. An important attribute for this frontogenesis pattern is the 3D shape of the jet, whose idealization is summarized above.
Lagrangian Transport by Nonbreaking and Breaking Deep-Water Waves at the Ocean Surface
Authors: Pizzo Nick , Melville W. Kendall , Deike Luc 
Published: February 2019

AbstractUsing direct numerical simulations (DNS), Deike et al. found that the wave-breaking-induced mass transport, or drift, at the surface for a single breaking wave scales linearly with the slope of a focusing wave packet, and may be up to an order of magnitude larger than the prediction of the classical Stokes drift. This model for the drift due to an individual breaking wave, together with the statistics of wave breaking measured in the field, are used to compute the Lagrangian drift of breaking waves in the ocean. It is found that breaking may contribute up to an additional 30% to the predicted values of the classical Stokes drift of the wave field for the field experiments considered here, which have wind speeds ranging from 1.6 to 16 m s−1, significant wave heights in the range of 0.7–4.7 m, and wave ages (defined here as cm/u*, for the spectrally weighted phase velocity cm and the wind friction velocity u*) ranging from 16 to 150. The drift induced by wave breaking becomes increasingly more important with increasing wind friction velocity and increasing significant wave height.
Ground Validation of Surface Snowfall Algorithm in GPM Dual-Frequency Precipitation Radar
Authors: Le Minda , Chandrasekar V. 
Published: February 2019

AbstractExtensive evaluations have been performed on the dual-frequency classification module in the Global Precipitation Mission (GPM) Dual-Frequency Precipitation Radar (DPR) level-2 algorithm. Both rain type classification and melting-layer detection continue to show promising results in the validations. Surface snowfall identification is a feature newly added in the classification module to the recently released version to provide a surface snowfall flag for each qualified vertical profile. This algorithm is developed upon vertical features of Ku- and Ka-band reflectivity and dual-frequency ratio from DPR. In this paper, we validate this surface snowfall identification algorithm with ground radars including NEXRAD, NASA Polarimetric Radar (NPOL), and CSU–CHILL radar during concurrent precipitation events and GPM validation campaign Olympic Mountain Experiment (OLYMPEX). Other ground truth such as Precipitation Imaging Package (PIP) and ground report is also included in the validation. Based on 16 validation cases in the years 2014–18, the average match ratio between surface snowfall flag from space radar and ground radar is around 87.8%. Promising agreements are achieved with different validation sources. Algorithm limitation and potential improvement are discussed.
Antecedent North Pacific Jet Regimes Conducive to the Development of Continental U.S. Extreme Temperature Events during the Cool Season
Authors: Winters Andrew C. , Bosart Lance F. , Keyser Daniel 
Published: February 2019

Abstract
This study considers the development of continental U.S. extreme temperature events (ETEs) during the cool season (September–May), where extreme temperatures are defined in terms of percentiles and events are defined in terms of the spatial coverage of extreme temperatures. Following their identification, ETEs are classified into geographic clusters and stratified based on the state of the North Pacific jet (NPJ) stream prior to ETE initiation using an NPJ phase diagram. The NPJ phase diagram is developed from the two leading modes of NPJ variability during the cool season. The first mode corresponds to a zonal extension or retraction of the exit region of the climatological NPJ, while the second mode corresponds to a poleward or equatorward shift of the exit region of the climatological NPJ. The projection of 250-hPa zonal wind anomalies onto the NPJ phase diagram prior to ETEs demonstrates that the preferred state and evolution of the NPJ prior to ETEs varies considerably based on the geographic location of ETE initiation and the season. Southern plains extreme warm events are an exception, however, since extreme warm events in that location most frequently initiate following a retracted NPJ during all seasons. The NPJ phase diagram is subsequently utilized to examine a synoptic-scale flow evolution highly conducive to the initiation of southern plains extreme warm events via composite analysis. The composite analysis demonstrates that a retracted NPJ supports an amplification of the upper-tropospheric flow pattern over North America, which then induces persistent lower-tropospheric warm-air advection over the southern plains prior to ETE initiation.
Perioperative Management of Total Laryngectomy Patients: A Survey of American Head and Neck Society Surgeons
Authors: Ahmed Omar H. , Roden Dylan F. , Ahmed Yasmina C. , Wang Binhuan , Nathan Cherie-Ann O. , Myssiorek David 
Published: February 2019

Objectives: Standards of care for total laryngectomy (TL) patients in the postoperative period have not been established. Perioperative care remains highly variable and perhaps primarily anecdotally based. The aim of this study was to survey members of the American Head and Neck Society to capture management practices in the perioperative care of TL patients. Methods: In this survey study, an electronic survey was distributed to the international attending physician body of the American Head and Neck Society. Forty-five-question electronic surveys were distributed. A total of 777 members were invited to respond, of whom 177 (22.8%) fully completed the survey. The survey elicited information on management preferences in the perioperative care of TL patients. Differences in management on the basis of irradiation status and pharyngeal repair (primary closure vs regional or free flap reconstruction) were ascertained. Main outcomes and measures were time to initiate oral feeding, perioperative antibiotic selection and duration, and estimated pharyngocutaneous fistula rates. These measures were stratified by patient type. Results: Most respondents completed head and neck fellowships (77.0%) and practice at academic tertiary centers (72.3%). Ampicillin/sulbactam was the most preferred perioperative antibiotic (43.2%-49.1% depending on patient type), followed by cefazolin and metronidazole in combination (32.0%-33.7%) and then clindamycin (10.8%-12.6%). Compared with nonirradiated patients, irradiated patients were significantly more likely to have longer durations of antibiotics ( P < .05), longer postoperative times to initiate oral feeding ( P < .05), and higher estimated fistula rates ( P < .05). Additionally, in nonirradiated patients, flap-repaired patients (vs primary repair) were significantly more likely to have longer durations of antibiotics (odds ratio, 1.29; 95% confidence interval, 1.13-1.48) and postoperative times to initiate oral feeding (odds ratio, 2.24; 95% confidence interval, 1.76-2.84). Conclusions: Perioperative management of TL patients is highly variable. Management of antibiotics and oral feeding are significantly affected by irradiation status and scope of pharyngeal repair. Further studies are needed to standardize perioperative care for this unique patient population.
The Influence of Tobacco Retailer Density and Poverty on Tobacco Use in a Densely Populated Urban Environment
Authors: Farley Shannon M. , Maroko Andrew R. , Suglia Shakira F. , Thorpe Lorna E. 
Published: February 2019

Objectives: Researchers have identified associations between neighborhood-level factors (eg, income level, tobacco retailer density) and smoking behavior, but few studies have assessed these factors in urban environments. We explored the effect of tobacco retailer density, neighborhood poverty, and housing type (multiunit and public) on smoking in a large urban environment (New York City). Methods: We used data on smoking prevalence and individual sociodemographic characteristics from the 2011-2013 New York City Community Health Survey, data on tobacco retailers from the 2012 New York City Department of Consumer Affairs, data on neighborhood sociodemographic characteristics and population density from the 2009-2013 American Community Survey, and data on multiunit and public housing from the 2012 New York City Primary Land Use Tax Lot Output data set. We used aggregate neighborhood-level variables and ordinary least squares regression, geographic weighted regression, and multilevel models to assess the effects of tobacco retailer density and neighborhood poverty on smoking prevalence, adjusting for sociodemographic characteristics (age, sex, race/ethnicity, and education) and neighborhood population density. We also assessed interactions between tobacco retailer density and poverty and each housing type on smoking. Results: Neighborhood poverty positively and significantly modified the association between tobacco retailer density and prevalence of neighborhood smoking ( β = 0.003, P = .01) when we controlled for population density, sociodemographic characteristics, and types of housing. Neighborhood poverty was positively associated with the prevalence of individual smoking ( β = 0.0099, P < .001) when we adjusted for population density, sociodemographic characteristics, and type of housing. Conclusion: More research is needed to determine all the environmental factors associated with smoking prevalence in a densely populated urban environment.
Superselective renal artery embolization for bleeding complications after percutaneous renal biopsy: a single-center experience
Authors: Haochen Wang , Jian Wang , Li Song , Tianshi Lv , Xiaoqiang Tong , Yinghua Zou 
Published: February 2019

Objective This study aimed to determine if superselective renal artery embolization is a safe and effective method of treating bleeding complications after percutaneous renal biopsy. Methods From January 2006 to December 2017, 43 patients (22 men and 21 women, mean age: 44.5 ± 14.0 years) underwent angiography for post-biopsy bleeding complications following percutaneous biopsy. Patients underwent angiography and superselective artery embolization. We recorded serum creatinine and hemoglobin values to assess the effect of embolization. Results Successful embolization was achieved in all patients. There was a pseudoaneurysm in 10 cases, arteriovenous fistula in eight, contrast media extravasation in 16, arteriovenous fistula combined with contrast media extravasation in five, and pseudoaneurysm combined with arteriovenous fistula in four. The embolic substance was a microcoil only or combined with a gelatin sponge. The mean creatinine value was not different at 1 day and 1 week after embolization compared with before embolization. Mean hemoglobin values were significantly higher at 1 day and 1 week after embolization than before embolization. Conclusions Superselective renal artery embolization is a safe and effective treatment for post-biopsy bleeding complications after percutaneous renal biopsy. Lumbar or iliolumbar artery angiography is necessary if renal arteriography shows no signs of hemorrhage.
A comparison of different modes of pneumatic compression on muscle tissue oxygenation: An intraparticipant, randomised, controlled volunteer study
Authors: Nandwana Sanat K , Ho Kwok M 
Published: February 2019

Intermittent pneumatic compression (IPC) to the lower limbs is widely used as a mechanical means to prevent deep vein thrombosis in hospitalised patients. Due to a theoretical concern about impairing blood flow, thromboembolic-deterrent stockings and IPC are considered contraindicated for patients with peripheral vascular diseases by some clinicians. This study assessed whether IPC would alter peripheral limb muscle tissue oxygenation (StO2), and whether such changes were different during 10 minutes of sequential and single-compartment compressions. Twenty volunteers were randomised to have their left or right arm treated with a sequential or single-compartment IPC for 10 minutes, using the contralateral arm without compression as an intraparticipant control. After a five-minute wash-out period, the procedure was repeated on the same arm using the alternative mode of IPC. Both hands’ thenar muscles StO2 was monitored every two minutes for 10 minutes using the same near-infrared spectroscopy StO2 monitor. Both sequential (3.5%, 95% confidence intervals (CI) 2.7–4.2; p < 0.001) and single-compartment IPC (1.6%, 95% CI 0.4–2.8; p = 0.039) significantly increased muscle StO2 within 10 minutes compared to no compression; and the increments were higher during sequential compressions compared to during single-compartment compressions (2.1%, 95% CI 0.7–3.5; p = 0.023). This mechanistic study showed that both modes of IPC increased upper limb muscle StO2 compared to no compression, but the StO2 increments were higher with the multiple-chamber sequential compressions mode. Contrary to the theoretical concern that IPC may impair peripheral limb tissue oxygenation, our results showed that IPC actually increases oxygenation of the peripheral limb muscles, especially during the sequential compressions mode.
Long-term Outcomes of Meniscal Allograft Transplantation With and Without Extrusion: Mean 12.3-Year Follow-up Study
Authors: Lee Sang-Min , Bin Seong-Il , Kim Jong-Min , Lee Bum-Sik , Lee Chang-Rack , Son Dong-Wook , Park Jun-Gu 
Published: February 2019

Background: Meniscal allograft transplantation (MAT) is a widely performed surgical technique used to reconstruct meniscal deficiencies after meniscectomy. However, the long-term effects of extrusion on clinical and radiologic outcomes are unclear. Hypothesis: In long-term follow-up, extrusion after MAT would show poorer outcomes than nonextrusion and would lead to faster progression of arthritic changes. Study Design: Cohort study; Level of evidence, 3. Methods: Forty-five MAT cases (lateral, n = 36; medial meniscal, n = 9) with a minimum 8-year follow-up period were selected. The mean follow-up period was 12.3 years (range, 8.0-19.6 years). Data were collected on patients’ sex, age, surgical side, and mechanical axis deviation. Patients were categorized into 2 groups: extrusion (≥3 mm) and nonextrusion (<3 mm). Categories were based on extrusion length measured via magnetic resonance imaging taken 1 year after surgery. Joint space width (JSW) on the affected and contralateral sides was measured on bilateral weightbearing posterior-anterior radiographs at 45° of flexion at 3 time points (preoperative, 4-6 years postoperative, and >8 years postoperative). Differences of the measured and relative JSW values between the groups and differences at different time points were analyzed. The Lysholm score was used to evaluate clinical function. Results: Mean ± SD extrusion was 3.07 ± 0.82 mm. The extrusion and nonextrusion groups were composed of 19 (42.2%) and 26 (57.8%) patients, respectively. Analysis of JSW showed a difference in relative JSW between the groups at >8 years ( P = .017). At the point of transition from 4 to 6 years to >8 years, the differences in absolute JSW values were −1.25 ± 0.78 mm (extrusion group) and −0.58 ± 0.66 mm (nonextrusion group; P < .001). Relative JSW values also differed between groups (extrusion group, −0.22 ± 0.13; nonextrusion group, −0.04 ± 0.18; P < .001). No differences were observed in the Lysholm scores between the groups at each time point. Conclusion: Long-term follow-up after MAT revealed a greater decrease in JSW in the extrusion group than in the nonextrusion group. However, no significant differences in clinical outcomes were observed.