bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dorsal striatal dopamine D1 receptor availability predicts an instrumental bias in action learning
Authors: de Boer Lieke , Axelsson Jan , Chowdhury Rumana , Riklund Katrine , Dolan Raymond J. , Nyberg Lars , Bäckman Lars , Guitart-Masip Marc 
Published: December 2018

Significance
The brain’s dopaminergic pathways are crucially important for adaptive behavior. They are thought to enable us to approach rewards and stay away from punishments. During learning, dopaminergic reward prediction errors are thought to reinforce previously rewarded actions, so they become easier to repeat. This dopaminergic activity could lead to a systematic bias by which rewarded actions are more readily learned than rewarded inactions. We present two findings. First, dopamine receptors in cortex, dorsal striatum, and nucleus accumbens provide distinct sources of variance in the human brain. Second, the boost in an individual’s learning rate from previously rewarded actions is dependent on the dopamine receptor density in dorsal striatum, a central structure in the dopaminergic circuit.
LncRNA FOXC2-AS1 protects cardiomyocytes from doxorubicin-induced cardiotoxicity through activation of WNT1-inducible signaling pathway protein-1
Authors: Zhang Shenwei , Yuan Yiqiang , Zhang Zheng , Guo Jing , Li Jing , Zhao Kui , Qin Yanping , Qiu Chunguang 
Published: December 2018

ABSTRACT
Doxorubicin (Dox) is an anthracycline antibiotic that has been used to treat different cancers. Dox-induced cardiotoxicity is common in clinical practice, while its mechanism is unknown. It has been proved that lncRNA FOXC2-AS1 may promote doxorubicin resistance and WNT1-inducible signaling pathway protein-1 (WISP1) blocks doxorubicin-induced cardiomyocyte death. Our study aimed to investigate the involvement of lncRNA FOXC2-AS1 and WISP1 in doxorubicin-induced cardiotoxicity and to explore their interactions. In our study we observed that FOXC2-AS1 and WISP1 mRNA were downregulated in heart tissues of mice with Dox-induced cardiotoxicity. FOXC2-AS1 and WISP1 mRNA expression were positively correlated in mice with Dox-induced cardiotoxicity but not in healthy mice. Overexpression of FOXC2-AS1 promoted to viability of mice cardiomyocytes under Dox treatment and also increased the expression level of WISP1. In contrast, WISP1 overexpression showed no significant effect on FOXC2-AS1. We therefore conclude that lncRNA FOXC2-AS1 may upregulate WISP1 to protect cardiomyocytes from doxorubicin-induced cardiotoxicity.
City Reputation Indicators (CRIs): measuring inhabitants’ city representation / Indicadores de Reputación Urbana: midiendo la representación de una ciudad en sus habitantes
Authors: Bonaiuto Marino , Ariccio Silvia , De Dominicis Stefano , Fornara Ferdinando , Molinario Erica , Troffa Renato , Wang Haoxing 
Published: December 2018

Reputation is a socially mediated form of knowledge. In social psychology it has been studied with reference to different social actors (individuals, brands, cities, etc). However, the social-psychological conceptualization of city reputation lacks a consensual definition. This research aims to operationally define city reputation, via the construction and validation of the City Reputation Indicators (CRIs). The first and preliminary study ( N = 62) defines the underlying dimensions via six focus groups held in two Italian cities that differ in terms of their political/administrative and socio-demographic features. The second study ( N = 362) tests the properties of CRIs via a survey administered in Rome. Results show a first validation of the 12 CRIs’ scales, which represent a basic tool for the assessment of people’s perception of a city. Theoretical and applied implications are discussed, as well as development perspectives for improvements.
Agricultural Productivity and Forest Conservation: Evidence from the Brazilian Amazon
Authors: Koch Nicolas , zu Ermgassen Erasmus K.H.J. , Wehkamp Johanna , Oliveira Filho Francisco J.B. , Schwerhoff Gregor 
Published: December 2018

AbstractA mix of public policy and market interventions in the mid‐2000s led to historic reductions in deforestation in the Brazilian Amazon. The collateral impact of these forest conservation policies on agricultural production is still poorly understood, though evidence is sorely needed given the economic importance of agriculture in Brazil and many other forest‐rich countries. We construct a ten‐year panel dataset for agriculture and deforestation in the Brazilian Amazon (2004–2014), and use two complementary difference‐in‐difference strategies to estimate the causal effect of one of Brazil's flagship anti‐deforestation strategies, the Priority List (Municípios Prioritários), on agricultural production and productivity in three sectors: beef, dairy, and crop production. We find no evidence for trade‐offs between agriculture and forest conservation. Rather, reductions in deforestation in priority municipalities were paired with increases in cattle production and productivity (cattle/hectare), consistent with a model where policy‐induced decreases in the value of clearing new land cause credit‐constrained farmers to shift investments from deforestation to capital investments in farming. The policy had no consistent effect on dairy or crop production. Our results suggest that in regions with large yield gaps and where technologies for increasing yields are readily available, efforts to constrain agricultural expansion through improved forest conservation policies may induce intensification.
Arabidopsis species deploy distinct strategies to cope with drought stress
Authors: Bouzid M , He F , Schmitz G , Häusler R E , Weber A P M , Mettler-Altmann T , De Meaux J 
Published: December 2018

Abstract

Background and Aims
Water limitation is an important determinant of the distribution, abundance and diversity of plant species. Yet, little is known about how the response to limiting water supply changes among closely related plant species with distinct ecological preferences. Comparison of the model annual species Arabidopsis thaliana with its close perennial relatives A. lyrata and A. halleri, can help disentangle the molecular and physiological changes contributing to tolerance and avoidance mechanisms, because these species must maintain tolerance and avoidance mechanisms to increase long-term survival, but they are exposed to different levels of water stress and competition in their natural habitat.

Methods
A dry-down experiment was conducted to mimic a period of missing precipitation. The covariation of a progressive decrease in soil water content (SWC) with various physiological and morphological plant traits across a set of representative genotypes in A. thaliana, A. lyrata and A. halleri was quantified. Transcriptome changes to soil dry-down were further monitored.

Key Results
The analysis of trait covariation demonstrates that the three species differ in the strategies they deploy to respond to drought stress. Arabidopsis thaliana showed a drought avoidance reaction but failed to survive wilting. Arabidopsis lyrata efficiently combined avoidance and tolerance mechanisms. In contrast, A. halleri showed some degree of tolerance to wilting but it did not seem to protect itself from the stress imposed by drought. Transcriptome data collected just before plant wilting and after recovery corroborated the phenotypic analysis, with A. lyrata and A. halleri showing a stronger activation of recovery- and stress-related genes, respectively.

Conclusions
The response of the three Arabidopsis species to soil dry-down reveals that they have evolved distinct strategies to face drought stress. These strategic differences are in agreement with the distinct ecological priorities of the stress-tolerant A. lyrata, the competitive A. halleri and the ruderal A. thaliana.
Overcoming Suicidal Persons’ Resistance Using Productive Communicative Challenges during Police Crisis Negotiations
Authors: Sikveland Rein Ove , Kevoe-Feldman Heidi , Stokoe Elizabeth 
Published: December 2018

Abstract
This paper reveals how negotiators, from the police and emergency call centres, overcome resistance towards the negotiation from suicidal persons in crisis. Communication guidance to hostage and crisis negotiators recommends against challenging the person in crisis, focusing instead on a softer, rapportful approach. Using conversation analysis, we investigate how negotiators deal with resistance, turn by turn, in encounters collected from British police negotiators’ field recordings, and American police 9-1-1 dispatch telephone calls. In contrast to existing communication guidance, we show that and how challenges can be productive for bringing about positive shifts in suicidal persons’ behaviour. We demonstrate how negotiators challenge the reasoning in their interlocutors’ resistant responses and leverage these challenges productively in the next turn. By studying real (rather than hypothetical or simulated) negotiations, the study reveals the tacit expertise of negotiators and the communicative practices that optimize negotiation outcomes. These research findings have significant implications for existing communication guidance showing how negotiations are managed locally through the linguistic design of turns of talk.
KinVis: a visualization tool to detect cryptic relatedness in genetic datasets
Authors: Ullah Ehsan , Aupetit Michaël , Das Arun , Patil Abhishek , Al Muftah Noora , Rawi Reda , Saad Mohamad , Bensmail Halima 
Published: December 2018

Abstract

Motivation
It is important to characterize individual relatedness in terms of familial relationships and underlying population structure in genome-wide association studies for correct downstream analysis. The characterization of individual relatedness becomes vital if the cohort is to be used as reference panel in other studies for association tests and for identifying ethnic diversities. In this paper, we propose a kinship visualization tool to detect cryptic relatedness between subjects. We utilize multi-dimensional scaling, bar charts, heat maps and node-link visualizations to enable analysis of relatedness information.

Availability and implementation
Available online as well as can be downloaded at http://shiny-vis.qcri.org/public/kinvis/.

Supplementary information
Supplementary data are available at Bioinformatics online.
DNABarcodeCompatibility: an R-package for optimizing DNA-barcode combinations in multiplex sequencing experiments
Authors: Trébeau Céline , Boutet de Monvel Jacques , Wong Jun Tai Fabienne , Petit Christine , Etournay Raphaël 
Published: December 2018

Abstract

Summary
Using adequate DNA barcodes is essential to unambiguously identify each DNA library within a multiplexed set of libraries sequenced using next-generation sequencers. We introduce DNABarcodeCompatibility, an R-package that allows one to design single or dual-barcoding multiplex experiments by imposing desired constraints on the barcodes (including sequencer chemistry, barcode pairwise minimal distance and nucleotide content), while optimizing barcode frequency usage, thereby allowing one to both facilitate the demultiplexing step and spare expensive library-preparation kits. The package comes with a user-friendly interface and a web app developed in Java and Shiny (https://dnabarcodecompatibility.pasteur.fr), respectively, with the aim to help bridge the expertise of core facilities with the experimental needs of non-experienced users.

Availability and implementation
DNABarcodeCompatibility can be easily extended to fulfil specific project needs. The source codes of the R-package and its user interfaces are publicly available along with documentation at [https://github.com/comoto-pasteur-fr] under the GPL-2 licence.

Supplementary information
Supplementary data are available at Bioinformatics online.
Idealism and the Harmony of Thought and Reality
Authors: Hofweber Thomas 
Published: December 2018

AbstractAlthough idealism was widely defended in the history of philosophy, it is nowadays almost universally considered a non-starter. This holds in particular for a strong form of idealism, which asserts that not just minds or the mental in general, but our human minds in particular are metaphysically central to reality. Such a view seems to be excessively anthropocentric and contrary to what we by now know about our place in the universe. Nonetheless, there is reason to think that such a strong form of idealism is indeed correct. In this paper, I will present an argument for idealism of this kind through considerations about a harmony between our thought and reality. The central argument in favour of idealism will come from a possibly unexpected source: we can see that a strong form of idealism is true simply from considerations about our language alone. I shall argue that thinking about how we represent reality allows us to conclude that idealism is true, and thus that reality must be a certain way. But no argument of this kind seems to allow for a metaphysical conclusion like idealism, since considerations about our language alone only show how we represent reality, not how reality is. And thus idealism can’t possibly follow, since it concerns how reality is, not just how we represent it to be. A good part of the second half of the paper is devoted to showing how such an argument is possible after all, and that it really does establish idealism.
RW Doradus: A solar-type shallow contact binary with a new orbital period investigation
Authors: Sarotsakulchai Thawicharat , Qian Sheng-Bang , Soonthornthum Boonrucksar , Fernández Lajús Eduardo , Liu Nian-Ping , Zhou Xiao , Zhang Jia , Liao Wen-Ping , Reichart Daniel E , Haislip Joshua B , Kouprianov Vladimir V , Poshyachinda Saran 
Published: December 2018

Abstract
New CCD photometric light curves of the short-period (P = 0.285 d) eclipsing binary RW Dor are presented. The observations were performed with the PROMPT-8 robotic telescope at CTIO in Chile between 2015 March and 2017 March. Other eclipse timings were obtained from the 2.15 m JS telescope at CASLEO, San Juan, Argentina in 2011 December. Based on a light curve analysis, it is found that RW Dor is a W-type shallow contact binary with a fill-out factor f ∼ 11% and a high mass ratio q ∼ 1.587 (1/q = 0.63), where the hotter component is the less massive one (M1 ∼ 0.52 M⊙ and M2 ∼ 0.82 M⊙). For orbital-period investigation, 15 new eclipse times and those previously published were compiled. O − C analysis with very weak evidence suggests that a long-term decrease in period with a rate of dP/dt = −9.61 × 10−9 d yr−1 is superimposed on a cyclic variation (A3 = 0.0054 d and P3 = 49.9 yr). The long-term decrease can be interpreted as mass transfer from the more massive component to the less massive one, or combined with angular momentum loss via magnetic braking. In addition, the marginal contact phase, high mass ratio (1/q &gt; 0.4), and long-term decrease in period all suggest that RW Dor is a newly formed contact binary via Case A mass transfer, and it will evolve into a deeper normal contact binary. If the cyclic change is correct, the light travel-time effect via the presence of a cool third body will be a more plausible explanation for this.
Augustan Allusion: Quotation and Self-Quotation in Pope’s Odyssey
Authors: Calvert Ian 
Published: December 2018

Abstract
The status of Pope’s Homer as a text which engages with numerous seventeenth-century poems and translations of classical epics is well established. Much of the criticism on this topic has so far focused on Pope’s use of Paradise Lost and Dryden’s Works of Virgil. This article contends that Pope’s use of other writers in the translation, including Denham and Waller, has been under-appreciated. I examine some previously unacknowledged borrowings from Denham and Waller in Pope’s Odyssey and relate them to Pope’s use of Milton and Dryden. I suggest that, within the context of direct quotation of whole verse-lines, Pope was himself responsible for privileging the presence of certain seventeenth-century authors in his Homer translations over others. The quotations of complete lines from Milton and Dryden are designed as ‘outward-looking’, but those from Denham and Waller are more ‘inward-looking’ and represent moments where he is reflecting privately on the main characteristics of their allusive strategies. Pope acknowledges that where Denham’s primary intertextual relationship was with Waller, the key source for Waller himself was his own early poetry. Waller’s early poems had, in turn, frequently drawn on works by other poets, and I outline how, in his Homer translations, Pope too repeats certain quotations frequently enough that they begin to function as self-quotations. I subsequently connect this technique to Pope’s readiness to repeat lines across his Iliad and Odyssey that are (largely) of his own invention to suggest that, in general, Pope’s allusive poetics follow Waller’s intertextual practice more closely than those of his other antecedents.
The Elasticity of Intergenerational Substitution, Parental Altruism, and Fertility Choice
Authors: Carlos Córdoba Juan , Ripoll Marla 
Published: December 2018

Abstract
Dynastic models common in macroeconomics use a single parameter to control the willingness of individuals to substitute consumption both intertemporally, or across periods, and intergenerationally, or across parents and their children. This article defines the concept of elasticity of intergenerational substitution (EGS), and extends a standard dynastic model in order to disentangle the EGS from the EIS, or elasticity of intertemporal substitution. A calibrated version of the model lends strong support to the notion that the EGS is significantly larger than one. In contrast, estimates of the EIS suggests that it is at most one. What disciplines the identification is the need to match empirically plausible fertility rates for the U.S. We illustrate the potential role of the EGS in macroeconomics.
S VALUES FOR NEUROIMAGING PROCEDURES ON KOREAN PEDIATRIC AND ADULT HEAD COMPUTATIONAL PHANTOMS
Authors: Villoing Daphnée , Lee Ae-Kyoung , Choi Hyung-do , Lee Choonsik 
Published: December 2018

Abstract
Over the past decades, the application of single-photon emission computed tomography and positron emission tomography in neuroimaging has markedly increased. In the current study, we used a series of Korean computational head phantoms with detailed cranial structures for 6-, 9-, 12-, 15-y-old children and adult and a Monte Carlo transport code, MCNPX, to calculate age-dependent specific absorbed fraction (SAF) for mono-energetic electrons ranging from 0.01 to 4 MeV and S values for seven radionuclides widely used in nuclear medicine neuroimaging for the combination of ten source and target regions. Compared to the adult phantom, the 6-y phantom showed up to 1.7-fold greater SAF (cerebellum &lt; cerebellum) and up to 1.4-fold greater S values (vitreous body &lt; lens) for 123I. The electron SAF data, combined with our previous photon SAF data, will facilitate absorbed dose calculations for various cranial structures in patients undergoing neuroimaging procedures.
Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia
Authors: Tan Timothy , Guitart Joan , Gerami Pedram , Yazdan Pedram 
Published: December 2018

Background:
Premature desquamation of the inner root sheath (PDIRS) is considered one of the distinctive features in central centrifugal cicatricial alopecia (CCCA). However, PDIRS can be seen in other alopecia subtypes, and its utility in the diagnosis of CCCA has been debated. We aimed to examine a large cohort of alopecia cases for the presence of PDIRS in association with and without inflammation to determine whether PDIRS in noninflamed follicles can be used as a specific marker of CCCA.

Methods:
Retrospective analysis was performed on 501 histologically unambiguous cases of alopecia (111 of CCCA, 102 of lichen planopilaris, 62 of discoid lupus erythematosus, 16 of acne keloidalis nuchae, 27 of folliculitis decalvans, 80 of androgenetic alopecia, 97 of alopecia areata, and 6 of psoriatic alopecia). The frequency of PDIRS, including cases with and without inflammation, was determined.

Results:
PDIRS was identified in all alopecia subtypes evaluated. When PDIRS was identified in lichen planopilaris, discoid lupus erythematosus, acne keloidalis nuchae, and alopecia areata, 100% of cases were in inflamed follicles. PDIRS in noninflamed follicles occurred in 73% (81/111) of CCCA, 33% (2/6) of psoriatic alopecia, 11% (3/27) of folliculitis decalvans, and 1% (1/97) of androgenetic alopecia. The presence of PDIRS in at least one noninflamed hair follicle correlated with a diagnosis of CCCA with a sensitivity of 73% and a specificity of 98% (P-value <0.0001).

Conclusion:
Identifying PDIRS in noninflamed hair follicles is a useful histologic feature in the evaluation of scalp biopsies and seems to be relatively specific for CCCA.
Therapeutic effects of whole-body vibration on fracture healing in ovariectomized rats: a systematic review and meta-analysis
Authors: Chen Jinman , Ruan Hongfeng , Liu Yang , Bao Jiamin , Xu Hao , Yao Min , Cui Xuejun , Liang Qianqian , Wang Yongjun 
Published: December 2018

Abstract

Objective:
Whole-body vibration (WBV), providing cyclic mechanical stimulation, has been used to accelerate fracture healing in preclinical studies. This study aimed to summarize and evaluate the effects of WBV on bone healing in ovariectomized rat models and then analyze its potential effects on fractures in human postmenopausal osteoporosis.

Methods:
PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, VIP, SinoMed, and WanFang databases were searched from their inception date to September 2017, and an updated search was conducted in January 2018. Studies that evaluated the effects of WBV on bone healing compared with control groups in ovariectomized rats were included. Two authors selected studies, extracted data, and assessed the methodological quality. Meta-analyses were performed when the same outcomes were reported in two or more studies.

Results:
Nine eligible studies were selected. In treatment groups, callus areas were significantly improved in the first 3 weeks, normalized total bone volume and total tissue volume values increased dramatically at 8 weeks, and the mechanical tests showed a significant difference at the end point of the study.

Conclusions:
This study suggested that WBV could accelerate callus formation in the early phase of bone healing, promote callus mineralization and maturity in the later phase, and restore mechanical properties of bones.