bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONSIDERAZIONI MORFOLOGICHE ED ISTOGENETICHE SUI TUMORI GLOMICI IN BASE AD OTTO OSSERVAZIONI PERSONALI
Authors: Sirtori Carlo , Veronesi Umberto 
Published: April 2018

8 cases of glomic tumors (4 of epithelioid type, 4 of angiomatous type according to Masson) are described. The glomic tumor may arise in any vascular region, owing to the ubiquity of the epithelioid cells which are the originating elements. The following classification is proposed for the tumors which originate in the vessel-ruling tissues: 1) pheocromocytoma (from the adrenal chromaffin tissue); 2) paraganglioma (from carotid gland and aortic body and from jugular and coccygeal glomera); 3) glomic tumor (from the glomerular arterio-venous anastomoses); 4) pericytoma (from the pericytes). The two last forms are histologically rather similar. The intermediate forms are also frequent.
LE METASTASI LATEROCERVICALI DI TUMORI DELLA TIROIDE
Authors: Vitagliano Giovanni 
Published: April 2018

Laterocervical tumours showing papilliferous aspect and known as « Laterocervical Aberrant Thyroids » are discussed. It is referred upon the debated question whether to consider them as embryonal rests in pathological growth, or metastases from tumours of the thyroid gland. The anatomical and functional differences among thyroid gland, accessory thyroids (or median aberrant thyroids), and lateral aberrant thyroids, are pointed out. Five cases have been observed in the Pathology Departement of the Cancer Institute in Milan. A certain differentiation is shown by the cells, so that the degree of malignancy is not always easy to recognise (Sirtori's « D » cells) and owing to the macroscopical and microscopical pictures the conclusion is drawn that these neoformations are to be considered as laterocervical metastases from papilliferous carcinomas of the thyroid gland.
I DERMATOFIBROMI
Authors: Vitagliano Giovanni 
Published: April 2018

A histological study of 146 Dermatofibromas is exposed. Areas of fibrosarcomatous transformation were observed in two cases. Melanin was found in tumour cells in seven cases. The preferred localizations are: lower limb (35), the upper limb (24), the back (23), the thorax (19). The correlations of Dermatofibroma with Keloid and Basalioma are discussed.
Ovaro-Surrenectomia Bilaterale per Cancro Mammario Incurabile e Metastatizzato
Authors: Bucalossi P. , Catania V. C. , Di Pietro S. , Somigli A. 
Published: April 2018

Bilateral oophoro-adrenalectomy was carried out in 12 cases of inoperable disseminated breast cancer. Results are referred. Subjective and objective improvements and particularly interesting laboratory data are exposed and discussed. The conclusion is drawn that oophoro-adrenalectomy may be considered as a sure though not decisive progress in the palliative therapy of advanced breast cancers.
MODIFICAZIONI DELL'ATTIVITA’ TRANSAMINASICA NEL TESSUTO NEOPLASTICO E NEI TESSUTI EMOPOIETICI DI RATTI PORTATORI DI MIELOMA IN FASE LEUCEMICA DOPO TRATTAMENTO CON SARCOCLORIN
Authors: Violante A. , Lorenzutti G. , Ragni A. 
Published: April 2018

The changes of two transaminase activities in hemopoietic tissues of leukemic and normal rats following Sarcoclorin treatment have been studied. A tendency to normalization of the enzymatic activiaies examined in liver and spleen of the treated leukemic rats has been obtained. In the normal animals the cytostatic drug induces a slight increase of both enzymatic activities in liver and spleen, while in the marrow a decrease of the alaninaaspartic-ketoglutaric-transaminase ratio is observed.
Studio Anatomo-Istologico del Corpo Uterino dopo Telecobaltoterapia in Alcuni Casi di Anedocarcinoma Endometriale ()
Authors: Francini M. A. 
Published: April 2018

The uterine body is studied from an anatomico-pathological point of view in 3 cases of endometrial carcinoma submitted to pre-operative telecobaltotherapy (6600 r). The macroscopic examination and the serial histological sections revealed, in the three cases under study, the tumour disappearance; in two cases, however, nests of residual epithelial cells with anaplastic characters were observed. Apart from the estimation of the therapeutic efficacy of Telecobaltotherapy –- which cannot be evaluated in such a small number of cases –- some considerations are exposed on the scarce connective and phlogistic reactions induced by this radiating therapy. The observed picture is in agreement with earlier observations on cervical carcinoma and on satellite lymph nodes surgically removed after Telecobaltotherapy.
La Restaurazione Protesica Negli Operati Di Resezione Del Mascellare Superiore per Neoplasia
Authors: Catania V. C. , Cislaghi E. 
Published: April 2018

The total resection of the superior maxillary bone is mainly indicated in tumours of the infra- and mesostructure. The wide endo-oral defect residual at the surgical operation causes a number of troubles which are characterized by retraction with sinking of the facial skin flap, rhinolalia, dysphagia with nasal backflow. In most of the cases reported the standardized technique of the operation and its good long-term results allowed a prosthetic reconstruction. The prosthetic reconstruction not only favoured the cicatricial evolution of the endo-oral defect, but also risulted in the rilief of troubles and deficiencies following the surgical demolition, For this purpose, the authors have employed a temporary teeth-free prosthesis, applied 10 to 20 days after the operation and left in position during the first two months, and, later, a permanent prosthesis with teeth. Results were highly sotisfactory both fram a functional and aesthetic standpoint. The prosthesis was of varying type according to the size of the endo-oral defect as well as to the condition of the remaining teeth. In some cases the prosthesis was supported by steel hooks whereas in other ones Witallium-melted ferrules were anchored to the contralateral teeth. In teeth-free patients the preference has been given to a complete higher and lower prosthesis, with the magnetic system.
Preoperative Hyperthermia Combined with Chemotherapy and Irradiation for the Treatment of Patients with Esophageal Carcinoma
Authors: Kuwano Hiroyuki , Sumiyoshi Kohei , Watanabe Masayuki , Sadanaga Noriaki , Nozoe Tadahiro , Yasuda Mitsuhiro , Sugimachi Keizo 
Published: April 2018

Aims and Background The purpose of this study was to investigate the combined effects of hyperthermia, chemotherapy and irradiation on esophageal cancer. Methods and material Since 1978, we have clinically applied hyperthermia combined with chemotherapy and irradiation (HCR therapy), to patients with carcinoma of the esophagus. The clinical results of 136 patients receiving preoperative HCR therapy were then compared with those of 107 cases undergoing preoperative chemo-radiotherapy (CR). Results A histological examination of the resected esophagus after preoperative treatment revealed that 65.4% and 50.5% of the patients responded markedly (no viable cancer cells) and moderately (more than two thirds of all cancer cells destroyed) to HCR and CR therapies, respectively (p <0.05). The five-year survival rates were 22.3% and 13.7% in the HCR and CR groups, respectively, and the difference was statistically significant (p <0.01). In particular, for the patients classified as TNM Stages III and IV, a significantly longer survival period was obtained with HCR therapy (p <0.05). In addition, no severe side effects were encountered in the patients given just hyperthermia. Conclusion Our clinical results suggest that preoperative hyperthermo-chemo-radiotherapy shows great promise for treatment of patients with advanced carcinoma of the esophagus.
Hypofractionated Radiation Therapy for Inoperable Advanced Stage Non-small Cell Lung Cancer
Authors: Donato Vittorio , Zurlo Alfredo , Bonfili Pierluigi , Petrongari Mariagrazia , Santarelli Mario , Costa Antonio , Enrici Riccardo Maurizi 
Published: April 2018

Aims and Background Inoperable advanced stage lung cancer is usually treated by radiation therapy. Although a minority of patients may achieve prolonged survival with aggressive therapeutic approaches, most patients present with adverse prognostic factors that do not allow curative treatment. For these cases palliation of symptoms becomes the main treatment purpose, and short treatment schedules are commonly employed. Methods Fifty-two inoperable patients with stage IIIB or IV non-small cell lung cancer (NSCLC) were treated with a hypofractionated schedule of radiotherapy. Initially all patients received 20 Gy in five fractions, and approximately one month after irradiation completion patients underwent clinical and radiological evaluation. Those that achieved a >50% reduction in tumor load and respiratory symptoms were submitted to a second similar short course of radiotherapy. Results Thirty-three (63%) patients received only one course of radiotherapy. After the first evaluation, 19 patients (37%), all stage IIIB, fulfilled the criteria to receive a total dose of 40 Gy. Survival rates at one and two years were 33% and 0%, respectively, in the group of patients that received 20 Gy, and 52% and 21% respectively, in the group treated with 40 Gy. Two-year survival rates were 10% for stage IIIB and 0% for stage IV patients. Among the patients that were irradiated with a dose of 20 Gy, a subjective reduction of dyspnea and cough and remission of hemoptysis were observed in 97%, 82% and 80% cases, respectively. Complete remission of dyspnea and coughing was observed in 17 (89%) and 14 (74%) patients treated with two irradiation courses. Only mild toxicity was recorded. Conclusions Our treatment schedule achieved symptom control in the majority of patients. Early evaluation after 20 Gy allowed selection of responsive patients that could benefit from more prolonged treatment.
Basaloid Carcinoma of the Lung with Bronchiolo-alveolar Cell Differentiation. A Case Report
Authors: Mai Kien T. , Perkins D. Garth , Veinot John P. , Shamji Farid M. 
Published: April 2018

Aims We report a case of pulmonary basaloid carcinoma with bronchiolo-alveolar cell differentiation. Patients and Results A 75 year-old presented with a tumor measured 2.0 cm and was located in the periphery of the left upper lobe. Histologically, the lesion consisted of nests of basaloid cells, and lumina and clefts lined by tumor cells with features of mucous cells or type II pneumocytes or with mixed features. Conclusions Previously reported basaloid carcinomas of the upper aero-digestive tract and lung have been purported to have an aggressive behavior. The tumor in the present study had features of a histopathological low grade tumor including a low mitotic rate, no tumor necrosis and a growth pattern at the periphery similar to that of bronchiolo-alveolar carcinoma.
Mortality of Parents of Children with Cancer: A Population-based Study in Turin, Italy
Authors: Mosso Maria Luisa , Magnani Corrado , Pastore Guido , Terracini Benedetto 
Published: April 2018

Aims and Background A cohort study was conducted in order to measure cause-specific mortality among parents of children recorded in the Childhood Cancer Registry of Piedmont. It is the first study carried out on the subject in southern Europe. Methods and Study Design The study comprised the 740 children resident in Turin and in whom a cancer had been diagnosed in the period 1967-1991. Nominal data were obtained for 723 fathers and 733 mothers. At the end of the follow-up in 1995, 645 fathers were alive, 68 dead and 10 untraceable. Corresponding figures for mothers were 700, 28 and 5. Cause of death was known for 91 of 96 parents. Results The period of observation of parents started on the birth of the index child, however mortality analyses were restricted to the period after 1965 because of limited availability of local reference rates. Total mortality was lower than expected among fathers (66 observed deaths vs 88.2 expected, P <0.05) and mothers (28 vs 31.4). Fathers showed deficits (not statistically significant) of lung neoplasms (4 vs 9.9), cardiovascular diseases (18 vs 27.1) and hepatic cirrhosis (2 vs 6.6). No statistically significant variations in mortality were observed with time from diagnosis or according to life status of the children. No cancer deaths occurred among the mothers of sarcoma cases whereas 1.9 were expected. Conclusions The data do not indicate any increase in mortality from cancer or other causes and, on the contrary, show a reduction in mortality which was more evident for the causes related to life style.
Trends in the Body Mass Index of Pediatric and Adult Patients Undergoing Anterior Cruciate Ligament Reconstruction
Authors: Burns Ethan A. , Collins Alexander D. , Jack Robert A. , McCulloch Patrick C. , Lintner David M. , Harris Joshua D. 
Published: April 2018

Background: The body mass index (BMI) in the United States (US) is rising and may be contributing to increased anterior cruciate ligament reconstruction (ACLR) rates. It is currently unknown whether the BMI is increasing in patients who undergo ACLR. Purpose: To determine whether (1) the BMI changed in pediatric and adult patients who previously underwent ACLR or revision ACLR over a 10-year eligibility period, (2) the BMI changed at a greater rate in pediatric or adult patients, and (3) the percentage of overweight and obese patients in the ACLR population was different than that of the general overweight population. Study Design: Case series; Level of evidence, 4. Methods: A retrospective investigation of patients who underwent ACLR by 6 surgeons from June 3, 2005, to June 3, 2015, was conducted. Patients were divided into pediatric (<18 years) and adult (≥18 years) categories. BMI at the time of surgery was defined as underweight (<18.5 kg/m2), normal (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2), and obese (≥30.0 kg/m2). Patients with an indeterminate BMI were excluded. Comparisons of overweight and obese patients were made with general population trends determined by the Centers for Disease Control and Prevention (CDC) in a single US state. Pearson ( R) and Spearman ( Rs) correlations were used to determine correlations, Student t tests were used for 2-variable comparisons, analyses of variance were used for multivariable comparisons, and analyses of covariance were used for comparing linear relationships. Results: There were 1305 patients (733 male, 572 female; 409 pediatric, 896 adult) included. Adults requiring surgical revision demonstrated a strong positive correlation with respect to BMI over time ( Rs = 0.906, P < .01). No other statistically significant trends in the BMI over time were found. The proportion of overweight pediatric patients undergoing ACLR was significantly greater than that of the general overweight pediatric population ( P < .05), and the proportion of obese pediatric and adult patients in the general population was greater than that of the obese patients in the study cohort ( P < .05). Conclusion: Between 2005 and 2015, the BMI for pediatric and adult patients who underwent ACLR did not demonstrate a significant change over time. However, there was a statistically significant strong positive correlation for increasing BMI in adult patients requiring revision, although the mean BMI in patients who underwent revision was less than that of the general population. In addition, the percentage of overweight pediatric patients undergoing ACLR was significantly greater than that of the general population of overweight patients in a single US state reported by the CDC.
Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: an open label, non-randomized, controlled study
Authors: Bhanpuri Nasir H. , Hallberg Sarah J. , Williams Paul T. , McKenzie Amy L. , Ballard Kevin D. , Campbell Wayne W. , McCarter James P. , Phinney Stephen D. , Volek Jeff S. 
Published: April 2018

AbstractBackgroundCardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D). We recently reported that glycemic control in patients with T2D can be significantly improved through a continuous care intervention (CCI) including nutritional ketosis. The purpose of this study was to examine CVD risk factors in this cohort.MethodsWe investigated CVD risk factors in patients with T2D who participated in a 1 year open label, non-randomized, controlled study. The CCI group (n = 262) received treatment from a health coach and medical provider. A usual care (UC) group (n = 87) was independently recruited to track customary T2D progression. Circulating biomarkers of cholesterol metabolism and inflammation, blood pressure (BP), carotid intima media thickness (cIMT), multi-factorial risk scores and medication use were examined. A significance level of P < 0.0019 ensured two-tailed significance at the 5% level when Bonferroni adjusted for multiple comparisons.ResultsThe CCI group consisted of 262 participants (baseline mean (SD): age 54 (8) year, BMI 40.4 (8.8) kg m−2). Intention-to-treat analysis (% change) revealed the following at 1-year: total LDL-particles (LDL-P) (− 4.9%, P = 0.02), small LDL-P (− 20.8%, P = 1.2 × 10−12), LDL-P size (+ 1.1%, P = 6.0 × 10−10), ApoB (− 1.6%, P = 0.37), ApoA1 (+ 9.8%, P < 10−16), ApoB/ApoA1 ratio (− 9.5%, P = 1.9 × 10−7), triglyceride/HDL-C ratio (− 29.1%, P < 10−16), large VLDL-P (− 38.9%, P = 4.2 × 10−15), and LDL-C (+ 9.9%, P = 4.9 × 10−5). Additional effects were reductions in blood pressure, high sensitivity C-reactive protein, and white blood cell count (all P < 1 × 10−7) while cIMT was unchanged. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk score decreased − 11.9% (P = 4.9 × 10−5). Antihypertensive medication use was discontinued in 11.4% of CCI participants (P = 5.3 × 10−5). The UC group of 87 participants [baseline mean (SD): age 52 (10) year, BMI 36.7 (7.2) kg m−2] showed no significant changes. After adjusting for baseline differences when comparing CCI and UC groups, significant improvements for the CCI group included small LDL-P, ApoA1, triglyceride/HDL-C ratio, HDL-C, hsCRP, and LP-IR score in addition to other biomarkers that were previously reported. The CCI group showed a greater rise in LDL-C.ConclusionsA continuous care treatment including nutritional ketosis in patients with T2D improved most biomarkers of CVD risk after 1 year. The increase in LDL-cholesterol appeared limited to the large LDL subfraction. LDL particle size increased, total LDL-P and ApoB were unchanged, and inflammation and blood pressure decreased.Trial registrationClinicaltrials.gov: NCT02519309. Registered 10 August 2015
RETRACTED ARTICLE: Notes on the result of solutions of the equilibrium equations
Authors: He Gaiping , Wang Lihong , Rodrigo Ben 
Published: April 2018

AbstractIn this short note, we correct some expressions obtained by Wang et al. (Bound. Value Probl. 2015:230, 2015). The corrected expressions will be useful for evaluating the boundary behaviors of solutions of modified equilibrium equations with finite mass subject. Moreover, the correction of Theorem 2.1 is also given.
Long‐term outcome of a moderately hypofractionated, intensity‐modulated radiotherapy approach using an endorectal balloon for patients with localized prostate cancer
Authors: Teh Bin S. , Lewis Gary D. , Mai Weiyuan , Pino Ramiro , Ishiyama Hiromichi , Butler Edward Brian 
Published: April 2018

AbstractBackgroundTechnical advances in radiotherapy delivery have simultaneously enabled dose escalation and enhanced bladder and rectal sparing. However, the optimal radiation fractionation regimen for localized prostate cancer is unclear. Laboratory and clinical evidence suggest that hypofractionation may improve the therapeutic ratio of radiotherapy. We report our institutional outcomes using moderately hypofractionated, intensity‐modulated radiotherapy (IMRT), and an endorectal balloon, with emphasis on long‐term biochemical control and treatment‐related adverse events in patients with localized prostate cancer.MethodsBetween January 1997 and April 2004, 596 patients with cT1–T3 prostate cancer underwent IMRT using a moderate hypofractionation regimen (76.70 Gy at 2.19 Gy/fraction) with an endorectal balloon. Using D'Amico classification, 226 (37.9%), 264 (44.3%), and 106 (17.8%) patients had low‐, intermediate‐, or high‐risk disease, respectively. The majority of intermediate‐ and high‐risk patients received androgen deprivation therapy. Biochemical relapse‐free survival (bRFS) was evaluated using 2005 Phoenix criteria and estimated using the Kaplan–Meier method.ResultsThe median follow‐up was 62 months. Overall 5‐ and 10‐year bRFS rates were 92.7% and 87.7%. For low‐, intermediate‐, and high‐risk patients, the 5‐year bRFS rates were 96.9%, 93.3%, and 82.0%, respectively; the 10‐year bRFS rates were 91.4%, 89.3%, and 76.2%, respectively. Prostate‐specific antigen, Gleason score, and T stage were significant predictors of bRFS (all P < 0.01). The 5‐year rates of severe (≥ Grade 3) adverse events were very low: 1.2% for gastrointestinal events and 1.1% for genitourinary events.ConclusionsLong‐term outcomes after moderately hypofractionated IMRT are encouraging. Moderate hypofractionation represents a safe, efficacious, alternative regimen in the treatment of localized prostate cancer.
Non-financial incentives and professional health workers’ intentions to stay in public district hospitals in Rwanda: A cross-sectional study
Authors: Ndikumana Celestin , Kwonyike Joshua , Tubey Ruth 
Published: April 2018

Background: Evidence shows that human resources represent a pillar that supports the healthcare system. As a result, retaining the health workforce has been considered to be a way of significantly improving of the quality of healthcare services. However, the challenge of retaining the health workforce has been an issue of concern in Rwanda. The purpose of this study was to assess the level of availability and provision of non-financial incentives, and their association with professional health workers’ intentions to stay in public district hospitals. Methods: A cross-sectional survey research design with a quantitative approach was used. With a population of 469 health workers from four district hospitals in Kigali, Rwanda, the study used a sample of 252 individuals. The study measured the perceived levels of variability and provision of working conditions, training and development, career development opportunities, and intentions to stay. Logistic regression was used to show associations between predictors and the outcome variable with 95% confidence intervals. Results: The findings of the study show significant associations between predictors and the outcome variable. In fact, average and high perceptions on working conditions are associated with professional health workers’ likelihood of staying in the hospital (OR: 9.70, P<0.001 and OR: 5.77, P=0.001, respectively). Similarly, an average and high level of perception on the availability of career development opportunities is a predictor of intention to stay (OR: 13.98, P<0.001 and OR: 12.26, P=0.038, respectively). In the same view point, there is a likelihood that health workers who perceive high level of training will stay (OR 1.025; P=0.014). Conclusion: There is evidence of significant associations between predictors and the outcome variable. However, the current status of non-financial incentives may adversely affect health workers’ intentions to stay.
Arrian's Preface to the Anabasis Alexandrou and Plutarch's Prologue to the Life of Alexander
Authors: Burliga Bogdan 
Published: April 2018

Arrian's Preface to the Anabasis Alexandrou and Plutarch's Prologue to the Life of Alexander
It is usually maintained that the main object of Arrian’s criticism in his Anabasis are the historians of Alexander the Great. In the following I would like to argue that one of the writers Arrian criticized was also Plutarch of Chaeronea who wrote an influential biography of the Macedonian king. Although Arrian never referred directly to Plutarch’s Life of Alexander, he read not only many historical works on the king but used and criticized other accounts, called by him ta legomena (‘tales’). To this latter group Plutarch’s vita Alexandri should be included as well.