bluuebunny/crossref_metadata_2025_split huggingface dataset:
The measurement postulates of quantum mechanics are operationally redundant
Authors: Masanes Lluís , Galley Thomas D. , Müller Markus P. 
Published: March 2019

AbstractUnderstanding the core content of quantum mechanics requires us to disentangle the hidden logical relationships between the postulates of this theory. Here we show that the mathematical structure of quantum measurements, the formula for assigning outcome probabilities (Born’s rule) and the post-measurement state-update rule, can be deduced from the other quantum postulates, often referred to as “unitary quantum mechanics”, and the assumption that ensembles on finite-dimensional Hilbert spaces are characterized by finitely many parameters. This is achieved by taking an operational approach to physical theories, and using the fact that the manner in which a physical system is partitioned into subsystems is a subjective choice of the observer, and hence should not affect the predictions of the theory. In contrast to other approaches, our result does not assume that measurements are related to operators or bases, it does not rely on the universality of quantum mechanics, and it is independent of the interpretation of probability.
Improving the Assessment of Breath-Holding Induced Cerebral Vascular Reactivity Using a Multiband Multi-echo ASL/BOLD Sequence
Authors: Cohen Alexander D. , Wang Yang 
Published: March 2019

AbstractBreath holding (BH) is a viable vasodilatory stimulus for calculating functional MRI-derived cerebral vascular reactivity (CVR). The BH technique suffers from reduced repeatability compared with gas inhalation techniques; however, extra equipment is needed to perform gas inhalation techniques, and this equipment is not available at all institutions. This study aimed to determine the sensitivity and repeatability of BH activation and CVR using a multiband multi-echo simultaneous arterial spin labelling/blood oxygenation level dependent (ASL/BOLD) sequence. Whole-brain images were acquired in 14 volunteers. Ten subjects returned for repeat imaging. Each subject performed four cycles of 16 s BH on expiration interleaved with paced breathing. Following standard preprocessing, the echoes were combined using a T2*-weighted approach. BOLD and ASL BH activation was computed, and CVR was then determined as the percent signal change related to the activation. The “M” parameter from the Davis Model was also computed by incorporating the ASL signal. Our results showed higher BH activation strength, volume, and repeatability for the combined multi-echo (MEC) data compared with the single-echo data. MEC CVR also had higher repeatability, sensitivity, specificity, and reliability compared with the single-echo BOLD data. These data support the usefulness of an MBME ASL/BOLD acquisition for BH CVR and M measurements.
Effects of endophytic fungi diversity in different coniferous species on the colonization of Sirex noctilio (Hymenoptera: Siricidae)
Authors: Wang Lixiang , Ren Lili , Li Chunchun , Gao Chenglong , Liu Xiaobo , Wang Ming , Luo Youqing 
Published: March 2019

AbstractDiversity of endophyte communities of the host tree affects the oviposition behavior of Sirex noctilio and the growth of its symbiotic fungus Amylostereum areolatum. In this study, we evaluated the structure and distribution of endophyte communities in the host tree (Pinus sylvestris var. mongolica) of S. noctilio and eight potential host tree species in China. Overall, 1626 fungal strains were identified by using internal transcribed spacer sequencing and morphological features. Each tree species harbored a fungal endophyte community with a unique structure, with the genus Trichoderma common to different communities. The isolation and colonization rate of endophytes from Pinus tabulaeformis, followed by P. sylvestris var. mongolica, were lower than those of other species. The proportion of endophytic fungi that strongly inhibited S. noctilio and symbiotic fungus growth was significantly lower in P. tabulaeformis, P. sylvestris var. mongolica and P. yunnanensis. Further, the diversity of the endophyte communities appeared to be predominantly influenced by tree species and the region, and, to a lesser extent, by the trunk height. Collectively, the data indicated that P. tabulaeformis might be at a higher risk of invasion and colonization by S. noctilio than other trees.
Dyslexia and age related effects in the neurometabolites concentration in the visual and temporo-parietal cortex
Authors: Kossowski Bartosz , Chyl Katarzyna , Kacprzak Agnieszka , Bogorodzki Piotr , Jednoróg Katarzyna 
Published: March 2019

AbstractSeveral etiological theories, in particular neuronal noise and impaired auditory sampling, predicted neurotransmission deficits in dyslexia. Neurometabolites also affect white matter microstructure, where abnormalities were previously reported in dyslexia. However findings from only few magnetic resonance spectroscopy studies using diverse age groups, different brain regions, data processing and reference scaling are inconsistent. We used MEGA-PRESS single-voxel spectroscopy in two ROIs: left temporo-parietal and occipital cortex in 36 adults and 52 children, where half in each group had dyslexia. Dyslexics, on average, had significantly lower total N-acetylaspartate (tNAA) than controls in the occipital cortex. Adults compared to children were characterized by higher choline and creatine in both areas, higher tNAA in left temporo-parietal and lower glutamate in the visual cortex, reflecting maturational changes in cortical microstructure and metabolism. Although the current findings do not support the proposed etiological theories of dyslexia, they show, for the first time, that tNAA, considered to be a neurochemical correlate of white matter integrity, is deficient in the visual cortex in both children and adults with dyslexia. They also point that several neurotransmitters, including ones previously used as reference, change with age.
Homoclinic and Heteroclinic Orbits in Climbing Cucumber Tendrils
Authors: Feng Jingjing , Zhang Wei , Liu Cheng , Guo Ming , Zhang Chunqiu 
Published: March 2019

AbstractMany biomaterials utilize chiral growth to imitate biological functions. A prominent example can be found in growing cucumbers, which use tendrils as winding support for both fixation and climbing. A number of tendril-mimicking materials and artificial plant-like mechanical machines have been developed to imitate tendril deformation. However, tendrils tend to not only show spiral or parallel shapes, but also a combination of both configurations. It remains unclear whether these morphologies are regular and how they form mechanically. Here, the morphology of climbing tendrils as a complex nonlinear phenomenon is investigated via experimental and theoretical approaches. The results of the experiments clarify the relationship between tendril morphologies and actual tendril growth as well as relevant stress characteristics during the climbing of a support by the tendril, and their mechanical properties. On this basis, the three-dimensional configuration problem of a cylinder-constrained rod has been utilized to describe the phenomenon of a tendril climbing support. The phenomena of spiral and parallel configuration combinations in tendrils could be effectively explained by studying similar homoclinic and heteroclinic orbits. Applying these results accurately guides the development of mimicking material.
Carfilzomib enhances cisplatin-induced apoptosis in SK-N-BE(2)-M17 human neuroblastoma cells
Authors: Lee Song-I , Jeong Yeon Ju , Yu Ah-Ran , Kwak Hyeok Jin , Cha Ji-Young , Kang Insug , Yeo Eui-Ju 
Published: March 2019

AbstractNeuroblastoma is a solid malignant tumor of the sympathetic nervous system, which accounts for 8–10% of childhood cancers. Considering the overall high risk and poor prognosis associated with neuroblastoma, effective therapeutics should be developed to improve patient survival and quality of life. A recent study showed that a proteasome inhibitor, carfilzomib (CFZ), reduced cell viability of SK-N-BE(2)-M17 neuroblastoma cells. Therefore, we investigated the molecular mechanisms by which CFZ lower the cell viability of neuroblastoma cells. CFZ reduced cell viability via cell cycle arrest at G2/M and apoptosis, which involved caspase activation (caspases-8, 9, 4, and 3), endoplasmic reticulum stress, reactive oxygen species production, mitochondrial membrane potential loss, and autophagy in a dose- and time-dependent manner. The effect of CFZ was additive to that of cisplatin (Cis), a well-known chemotherapeutic drug, in terms of cell viability reduction, cell cycle arrest, and apoptosis. Importantly, the additive effect of CFZ was maintained in Cis-resistant neuroblastoma cells. These results suggest that CFZ can be used in combination therapy for patients with neuroblastoma to overcome the resistance and adverse side effects of Cis.
The ventromedial prefrontal cortex is particularly responsive to social evaluations requiring the use of person-knowledge
Authors: Dang Tzipporah P. , Mattan Bradley D. , Kubota Jennifer T. , Cloutier Jasmin 
Published: March 2019

AbstractHumans can rely on diverse sources of information to evaluate others, including knowledge (e.g., occupation, likes and dislikes, education, etc.) and perceptual cues (e.g., attractiveness, race, etc.). Previous research has identified brain regions supporting person evaluations, but are evaluations based on perceptual cues versus person-knowledge processed differently? Moreover, are neural responses consistent when person-knowledge is available but unnecessary for the evaluation? This fMRI study examined how the use and availability of person-knowledge shapes the neural underpinnings of social evaluations. Participants evaluated well-known actors based on attractiveness or body of work (i.e., person-knowledge) and unknown models based on attractiveness only. Analyses focused on the VMPFC, following research implicating this region in positive evaluations based on person-knowledge. The VMPFC was sensitive to the (1) availability of person-knowledge, showing greater responses as ratings became more positive for actors (but not models) regardless of rating dimension and (2) use of available person-knowledge, showing greater activity as ratings for likability based on body of work became more positive for actors versus models rated on attractiveness. These findings indicate that although brain regions supporting person evaluation are sensitive to the availability to person-knowledge, they are even more responsive when judgments require the use of available person-knowledge.
Superior plasticity stability and excellent strength in Ti-55531 alloy micropillars via harmony slip in nanoscale α/β phases
Authors: Kou Wenjuan , Sun Qiaoyan , Xiao Lin , Sun Jun 
Published: March 2019

AbstractExcellent stability of plasticity and high strength are acquired in Ti55531 alloy micropillars via introducing a high density of deformable nanoscale α phase into a β matrix. The yield strength of the pillars is as high as 2.26 GPa irrespective of pillar sizes ranging from 6 to 0.3 μm, which is high enough to activate dislocation slip both in ductile α precipitates and the β matrix. The harmony slip model was proposed to interpret slip transmission between the nanoscale α phase and the divided β matrix, and both α and β accommodate their individual plasticity during compression. This results in an excellent combination of high strength and stable plasticity in Ti55531 alloy micron-to submicron pillars. The results highlight the novel strengthening and toughening mechanisms of nanostructured alloys and a specific type of microstructure that exhibits stable plasticity for nano/microdevices.
Penfluridol overcomes paclitaxel resistance in metastatic breast cancer
Authors: Gupta Nehal , Gupta Parul , Srivastava Sanjay K. 
Published: March 2019

AbstractPaclitaxel is a first line chemotherapeutic agent for the patients with metastatic breast cancer. But inherited or acquired resistance to paclitaxel leads to poor response rates in a majority of these patients. To identify mechanisms of paclitaxel resistance, we developed paclitaxel resistant breast cancer cell lines, MCF-7 and 4T1 by continuous exposure to paclitaxel for several months. Western blot analysis showed increased expression of HER2 and β-catenin pathway in resistant cell lines as compared to parent cells. Hence, we hypothesized that HER2/β-catenin mediates paclitaxel resistance in breast cancer and suppression of HER2/β-catenin signaling could overcome paclitaxel resistance. Our data showed that penfluridol (PFL) treatment significantly reduced the survival of paclitaxel-resistant cells. Western blot analysis revealed that PFL treatment suppressed HER2, as well as, β-catenin pathway. In vivo data confirmed that PFL significantly potentiated tumor growth suppressive effects of paclitaxel in an orthotropic breast cancer model. In addition, tumors from paclitaxel and PFL-treated mice showed reduced HER2 and β-catenin expression, along with increased apoptosis. Taken together our results demonstrate a novel role of HER2/β-catenin in paclitaxel resistance and open up new avenues for application of PFL as a therapeutic option for overcoming paclitaxel resistance.
Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro
Authors: Correa Ricardo , Coronado Lorena , Caballero Zuleima , Faral-Tello Paula , Robello Carlos , Spadafora Carmenza 
Published: March 2019

AbstractEven with access to sufficient nutrients and atmosphere, Plasmodium falciparum can barely be cultured at maximum growth capacity in vitro conditions. Because of this behavior, it has been suggested that P. falciparum has self-regulatory mechanisms in response to density stress. Only recently has this process begun to be acknowledged and characteristics of a programmed cell death been assigned to the parasite at high parasitaemia in vitro cultures. In searching for death signals within the parasite community, we have found that extracellular vesicles (EVs) of P. falciparum from high parasitaemia cultures are able to induce programmed cell death processes in the population. A comparative proteomic analysis of EVs from low (EVL) and high (EVH) parasitaemia cultures was conducted, pointing to lactate dehydrogenase from P. falciparum (PfLDH) as the only parasite protein overexpressed in the later. Although the major function of P. falciparum lactate dehydrogenase (PfLDH) is the conversion of pyruvate to lactate, a key process in the production of energy in most living organisms, we investigated its possible role in the mechanism of parasite density control by intercellular signaling, given that PfLDH had already been listed as a component of extracellular vesicles of P. falciparum. In this study we present evidence of the EV-associated PfLDH regulation of parasite population by inducing apoptosis in highly parasitized cultures.
LncRNA NEF inhibits migration and invasion of HPV-negative cervical squamous cell carcinoma by inhibiting TGF-β pathway
Authors: Ju Wencui , Luo Xiaoyong , Zhang Nan 
Published: March 2019

Abstract
LncRNA NEF was a recently identified tumor suppressor lncRNA in hepatocellular carcinoma. Our study aimed to explore the role of NEF in cervical squamous cell carcinoma (CSCC) patients. In the present study, expression of NEF in tumor tissue (cervical biopsies for healthy control) and serum of human papillomaviruses (HPV)-negative and HPV-positive CSCC patients as well as healthy controls was detected by qRT-PCR. Diagnostic and prognostic values of NEF for CSCC were evaluated by ROC curve and survival curve analysis, respectively. NEF expression vector was transfected into CSCC cells and the effects on cell migration and invasion as well as TGF-β1 expression were investigated by Transwell migration assay, Transwell invasion assay, and Western blot, respectively. We found that expression of NEF in cervical tissues (tumor tissues for CSCC patients) and serum was significantly down-regulated in HPV-negative CSCC patients than in healthy controls and HPV positive patients, but no significant differences were found between healthy controls and HPV positive patients. Low serum levels of NEF distinguished HPV-negative CSCC patients from healthy controls and indicated poor survival. NEF overexpression inhibited the migration and invasion of HPV-negative but not HPV-positive CSCC cells. NEF overexpression down-regulated TGF-β1 in HPV-negative CSCC cells but not in HPV-positive CSCC cells. TGF-β1 treatment reduced the effects of NEF overexpression on cell migration and invasion. Therefore, we conclude that lncRNA NEF may inhibit the migration and invasion of HPV-negative cervical squamous cell carcinoma by inhibiting TGF-β pathway.
LncRNA CASC11 promotes cancer cell proliferation in hepatocellular carcinoma by inhibiting miRNA-188-5p
Authors: Cheng Nan , Wu Ju , Yin Min , Xu Jian , Wang Yadong , Chen Xi , Nie Zhequn , Yin Jiajun 
Published: March 2019

Abstract
It is known that lncRNA CASC11 promotes the development of gastric cancer. Our study was carried out to investigate the possible involvement of ncRNA CASC11 in hepatocellular carcinoma (HCC). In the present study, we found that CASC11 was up-regulated, while miR-188-5p was down-regulated in tumor tissues of HCC patients. CASC11 and miR-188-5p were not affected by HBV and HCV infections. Follow-up study showed that high levels of CASC11 were significantly correlated with poor survival. Expression levels of CASC11 and miR-188-5p were inversely correlated in tumor tissues. CASC11 overexpression mediated the down-regulation of miR-188-5p, while miR-188-5p overexpression failed to affect CASC11 expression. CASC11 overexpression led to promoted, while miR-188-5p overexpression led to inhibited proliferation of cells of HCC cell lines. CASC11 overexpression showed no significant effects on cancer cell migration and invasion. In addition, miR-188-5p overexpression attenuated the enhancing effects of CASC11 overexpression on cancer cell proliferation. Therefore, LncRNA CASC11 promoted cancer cell proliferation in HCC possibly by inhibiting miR-188-5p.
How Mixed-Effects Modeling Can Advance Our Understanding of Learning and Memory and Improve Clinical and Educational Practice
Authors: Gordon Katherine R. 
Published: March 2019

Purpose
A key goal of researchers, clinicians, and educators within the fields of speech, language, and hearing sciences is to support the learning and memory of others. To do so, they consider factors relevant to the individual, the material to be learned, and the training strategy that can maximize learning and retention. Statistical methods typically used within these fields are inadequate for identifying the complex relationships between these factors and are ill equipped to account for variability across individuals when identifying these relationships. Specifically, traditional statistical methods are often inadequate for answering questions about special populations because samples drawn from these populations are usually small, highly variable, and skewed in distribution. Mixed-effects modeling provides advantages over traditional statistical techniques to answer complex questions while taking into account these common characteristics of special populations.

Method and Results
Through two examples, I illustrate advantages of mixed-effects modeling in answering questions about learning and memory and in supporting better translation of research to practice. I also demonstrate key similarities and differences between analysis of variance, regression analyses, and mixed-effects modeling. Finally, I explain three additional advantages of using mixed-effects modeling to understand the processes of learning and memory: the means to account for missing data, assess the contribution of variations in delay intervals, and model nonlinear relationships between factors.

Conclusions
Through mixed-effects modeling, researchers can disseminate accurate information about learning and memory to clinicians and educators. In turn, through enhanced statistical literacy, clinicians and educators can apply research findings to practice with confidence. Overall, mixed-effects modeling is a powerful tool to improve the outcomes of the individuals that researchers and practitioners serve within the fields of speech, language, and hearing sciences.
Das Innere Team als Beratungsmethode im forensischen
Setting
Authors: Weißkerber Maria 
Published: March 2019

ZusammenfassungLässt sich die Beratungsmethode des Inneren Teams im forensischen Setting
anwenden? Um das herauszufinden, haben wir den fiktiven Patienten Herrn B. im
Dialog mit seinem Inneren Team begleitet und beobachtet, ob er mithilfe der
Methodik Ambivalenzen auflösen und neue Handlungskompetenzen entwickeln
kann.
Heilsames Singen
Authors: Maeder Silke 
Published: March 2019

ZusammenfassungSingen kann jeder, man braucht dazu nichts anderes als seine Stimme. Es regt die
Selbstheilungskräfte an, macht ausgeglichener und stärkt das
Gemeinschaftsgefühl. Deshalb gründete unsere Autorin in ihrer Klinik eine Gruppe
für heilsames Singen und berichtet, worauf dabei zu achten ist.
Endoscopic tissue shielding to prevent bleeding after endoscopic submucosal dissection: a prospective multicenter randomized controlled trial
Authors: Kataoka Yosuke , Tsuji Yosuke , Hirasawa Kingo , Takimoto Kengo , Wada Tomonori , Mochizuki Satoshi , Ohata Ken , Sakaguchi Yoshiki , Niimi Keiko , Ono Satoshi , Kodashima Shinya , Yamamichi Nobutake , Fujishiro Mitsuhiro , Koike Kazuhiko 
Published: March 2019

Abstract
Background Bleeding after endoscopic submucosal dissection (ESD) is a severe adverse event. Recent reports have described the efficacy of the endoscopic shielding method with polyglycolic acid (PGA) sheets and fibrin glue for the prevention of adverse events after ESD. The aim of the present study was to investigate whether the PGA shielding method provides additional benefit in preventing post-ESD bleeding compared with standard care.
Methods This was a prospective, multicenter, randomized controlled trial. Patients at high risk of post-ESD bleeding were enrolled in the study. Before ESD, patients were randomized to either the PGA group or the control group. After completing ESD in the PGA group, PGA sheets were placed onto the ulcer floor and adhered with fibrin glue. The primary end point was the post-ESD bleeding rate.
Results 140 eligible patients were enrolled from September 2014 to September 2016, and 137 were included in the intention-to-treat analysis (67 in the PGA group and 70 in the control group). Post-ESD bleeding occurred in three patients (4.5 %) in the PGA group and in four patients (5.7 %) in the control group; there was no significant difference between the two groups (P > 0.99). Post-ESD bleeding tended to occur later in the control group than in the PGA group (median 12.5 days [range 8 – 14] vs. 2 days [range 0 – 7], respectively).
Conclusion The PGA shielding method did not demonstrate a significant effect on the prevention of post-ESD bleeding.