bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doses greater than 85 Gy and two isocenters in Gamma Knife surgery for trigeminal neuralgia: updated results
Authors: Morbidini-Gaffney Stefania , Chung Chung-Taik , Alpert Tracy Erin , Newman Nancy , Hahn Seung Shin , Shah Hemangini , Mitchell Lisa , Bassano Daniel , Darbar Aneela , Bajwa Saeed Ahmed , Hodge Charles 
Published: November 2018

ObjectThe purpose of this study was to assess the efficacy of Gamma Knife surgery (GKS) in treating patients with trigeminal neuralgia (TN). Preliminary results of this study were previously reported. The updated results are reported in this paper.MethodsNinety seven patients with TN refractory to medical or surgical management underwent GKS between September 1998 and October 2005. Fifteen patients had multiple sclerosis (MS). The radiation dose was escalated from 70 to 99 Gy. The Barrow Neurological Institute Pain Scale (BNIPS) was used to assess pain before and after GKS.Eighty-four patients were available for evaluation with a mean follow up of 8.9 months. The overall response and complete response rates were 70.2% and 36.9%, respectively. At 12 months, there was a greater improvement in BNIPS scores for patients who were treated with two isocenters compared with those treated with a single isocenter. The mean percentage of pain decrease was 56.26% compared with 11.53% (p < 0.001). Patients treated with two isocenters rather than one and patients receiving greater than 85 Gy compared with lower doses had a longer duration of response. Only nine patients (11%) had mild numbness attributable to the GKS. Five of the nine patients experienced complete resolution of facial numbness on follow up. Patients with MS have a shorter duration of response compared with those without MS (p = 0.35).Conclusions These updated results show that GKS continues to be an effective therapy for TN. It appears there is an enhanced response with doses 85 Gy or more and with two isocenters without increased complications.
Prediction of intracranial edema after radiosurgery of meningiomas
Authors: Novotný Jr. Josef , Kollová Aurelia , Liščák Roman 
Published: November 2018

ObjectThis study was focused on the development of models with which to predict the occurrence of intracranial edema after Gamma Knife surgery (GKS) of meningiomas, based on clinical and imaging data collected in a large group of patients.MethodsData in 368 patients with 381 meningiomas treated using the Leksell Gamma Knife unit were analyzed. Follow up of more than 24 months was available in 331 patients (90%); this time period ranged from 24 to 120 months (median 51 months). The actuarial tumor control rate was 97.9% at 5 years. Perilesional edema after GKS was radiologically confirmed in 51 patients (15.4%) and 32 of them (9.7%) were symptomatic; symptoms were temporary in 23 (6.9%) and permanent in nine (2.7%). Ten different factors were proposed as potential predictors for the occurrence of the intracranial edema after GKS: patient's sex, patient's age, previous surgery, edema before GKS treatment, lobulated margin of meningioma, heterogeneous appearance of the tumor, tumor volume, tumor location, maximum dose to the tumor, and dose to the tumor margin. To identify factors having influence on edema occurrence, univariate and multivariate statistical analyses were performed.There was a significant difference in the incidence of edema for different patient age groups and a significantly higher incidence of edema occurrence in patients in whom no surgical procedure was performed before GKS, those with edema present before GKS, those with a tumor volume larger than 10 cm3, those in whom the tumor was located in the anterior fossa, those in whom the maximum dose to the tumor was higher than 30 Gy, and for different tumor margin doses. A binary logistic regression multifactorial prediction model was used to identify the following significant factors to predict of edema occurrence after GKS: previous surgery, edema before the treatment, tumor volume, tumor location, and tumor margin dose.Conclusions Based on these models estimates of the occurrence of edema after the GKS can be made, and consequently treatment parameters can be adjusted to reduce the occurrence of edema. These results may provide grounds for additional patient care such as more frequent follow up or possibly administration of steroids.
Clinical analysis of Gamma Knife surgery for trigeminal schwannomas
Authors: Sun Shibin , Liu Ali , Wang Chongcheng , Luo Bin , Wang Meihua 
Published: November 2018

ObjectThe authors sought to assess the clinical effect of Gamma Knife surgery (GKS) for trigeminal schwannomas.MethodsBetween December 1994 and December 2003, 69 patients with trigeminal schwannomas underwent GKS, and 58 patients were followed up and reviewed at the Beijing Neurosurgical Institute. The mean target volume was 4.6 cm3. The mean peripheral dose was 13.1 Gy, and the mean central dose was 28.3 Gy. The mean radiological follow-up period was 42.5 months.Radiological follow-up demonstrated near-complete disappearance of the tumors in four patients (6.9%), in 34 patients (58.6%) a reduction was seen, in 16 patients (27.6%) no change was observed, and in four patients (6.9%) an enlargement was revealed. The overall tumor control rate was 93.1%. Improvement of presenting neurological symptoms was observed in 28 patients (48.3%), stabilization of presenting neurological symptoms was observed in 23 patients (39.6%), continued progression of presenting neurological symptoms was observed in seven patients (12.1%), and transient cranial nerve dysfunction was observed in six patients (10.4%). Among 13 patients with secondary trigeminal neuralgia, 10 patients had significant improvement or disappearance of trigeminal neuralgia after GKS.Conclusions Gamma Knife surgery provides an effective and safe primary and/or adjunct treatment for patients with small- to moderate-sized trigeminal schwannomas, with a low risk of iatrogenic cranial neuropathy and great improvement of clinical symptoms.
Management and outcome of hemorrhage after Gamma Knife surgery for arteriovenous malformations of the brain
Authors: Maruyama Keisuke , Shin Masahiro , Tago Masao , Kurita Hiroki , Kawahara Nobutaka , Morita Akio , Saito Nobuhito 
Published: November 2018

ObjectAppropriate management of hemorrhage after Gamma Knife surgery (GKS) for arteriovenous malformations (AVMs) of the brain is poorly understood, although a certain proportion of patients suffer from hemorrhage.MethodsAmong 500 patients observed for 1 to 183 months (median 70 months) after GKS, 32 patients (6.4%) suffered a hemorrhage. Hemorrhage developed even after angiographically documented obliteration of the AVM in five (2%) of 250 patients followed for 1 to 133 months (median 75 months) post-GKS. These patients had been treated according to their pathological condition. Treatment of these patients and their outcomes were retrospectively reviewed. As a management strategy in patients with preobliteration hemorrhage, the intracerebral hematoma and the AVM nidus were removed in four patients, and chronic encapsulated hematoma was removed in three. Among 11 patients who were conservatively treated, AVMs were ultimately obliterated in five, including three patients who underwent repeated GKS. Intracerebral hematoma from angiographically documented obliterated AVMs was radically resected in two patients, including one who also underwent aspiration of an accompanying symptomatic cyst. Intraoperative bleeding was easily controlled in these patients. Outcomes after hemorrhage, measured with the modified Rankin Scale, were significantly better in patients with postobliteration hemorrhage than in those with preobliteration hemorrhage (p < 0.05).Conclusions Various types of hemorrhagic complications after GKS for AVMs can be properly managed based on an understanding of each pathological condition. Although a small risk of bleeding remains after angiographically demonstrated obliteration, surgery for such AVMs is safe, and the patient outcomes are more favorable. Radical resection to prevent further hemorrhage is recommended for ruptured AVMs after obliteration because such AVMs can cause repeated hemorrhages.
How soon will the patient with metastasis return for radiosurgery?
Authors: Nakaya Kotaro , Hayashi Motohiro , Izawa Masahiro , Ochiai Taku , Hori Tomokatsu , Takakura Kintomo 
Published: November 2018

ObjectStereotactic radiosurgery for brain metastasis has become one of the standard treatment options in recent years. Some patients must undergo repeated stereotactic radiosurgery for new lesions. The authors retrospectively reviewed their data to estimate how soon the patients undergo repeated radiosurgery for new lesions.MethodsBetween October 1999 and March 2006, 1081 patients with brain metastases underwent Gamma Knife surgery (GKS) at Tokyo Women's Medical University. One hundred and forty-nine patients in whom GKS had been performed two or more times were evaluated. There were 68 men and 81 women with a median age of 61 years (range 29–90 years). The authors analyzed data on patient age, number of treated lesions, and period between GKSs. Follow-up imaging was performed in almost all patients every 2 to 3 months after GKS.The number of lesions treated in a single session varied from one to 35. The median interval between GKSs was 26 weeks (range 3–175 weeks) for patients with breast cancer and 23 weeks (range 4–179 weeks) for patients with non–small cell lung carcinoma.Conclusions It would appear that follow-up imaging studies should be obtained every 2 to 3 months after GKS to monitor patients for tumor recurrence.
Phase 1 Study of Edasalonexent (CAT-1004), an Oral NF-κB Inhibitor, in Pediatric Patients with Duchenne Muscular Dystrophy
Authors: Finanger Erika , Vandenborne Krista , Finkel Richard S. , Lee Sweeney H. , Tennekoon Gihan , Yum Sabrina , Mancini Maria , Bista Pradeep , Nichols Andrew , Liu Hanlan , Fretzen Angelika , Donovan Joanne M. 
Published: November 2018

Background: Edasalonexent is an orally administered small molecule designed to inhibit NF- κB, which is activated from infancy in Duchenne muscular dystrophy and is central to causing muscle damage and preventing muscle regeneration. Objective: Evaluate the safety, tolerability, pharmacokinetics and exploratory pharmacodynamics of three doses of edasalonexent in ambulatory males ≥4 to <8 years of age with genetically confirmed Duchenne muscular dystrophy. Methods: This was a 1-week, open-label, multiple-dose study with 3 sequential ascending doses (33, 67 and 100 mg/kg/day) of edasalonexent administered under different dietary conditions to 17 males with a mean age of 5.5 years. Results: All doses of edasalonexent were well tolerated, with no serious adverse events, no drug discontinuations and no dose reductions. The majority of adverse events were mild, and the most common adverse events were gastrointestinal (primarily diarrhea). Edasalonexent was rapidly absorbed with peak levels observed 2–6 hours after dosing and exposures appeared to increase nearly proportionally to dose for the 2 lower and all 3 doses under low-fat and high-fat meal conditions, respectively. Only minor plasma accumulation of edasalonexent was observed with 7 days of dosing. After treatment with edasalonexent for 7 days, levels of NF- κB-regulated genes and serum proteins were decreased. Conclusions: This first report of edasalonexent oral administration for one week in male pediatric patients with Duchenne muscular dystrophy showed that treatment was well tolerated and inhibited NF-kB pathways.
Primary community of modern ukrainian orthodox church as a form church of sociality
Authors: Borejko Yu. 
Published: November 2018

In the article Boreyko Yuri Grigorovich «Primary community of modern ukrainian orthodox church as a form church of sociality» set significance of the religious community as a social phenomenon and the parish as a center of the institutional structure of the church in shaping religious orthodox believers, the ratio of the parish and the community as a form of religious associations, the nature of the participation of the believers in the daily life of religious communities and their integration into the social relations within the parish and the community.
In the ocean God incarnations or "circles" evolution A. Besant
Authors: Kompaniec L. 
Published: November 2018

In the article Kompaniets Liliya Viktorivna In the ocean God incarnations or "circles" evolution A. Besant In Focus website is reconstructed evolutionary model the idea of reincarnation A. Besant. The epicenter of its unfolding acts topic incarnations «God Fire» from which the world «deployed» and that he «rolled» in the end times. Semantic levels of the idea of reincarnation through the prism of the embodiments disclosed spirits, gods, higher hierarchy «Sons of Fire» incarnation of the Logos
PENGELOLAAN PLASMA NUTFAH PERIKANAN DI JAWA TIMUR
Authors: Winarsih Wiwik Heny 
Published: November 2018

Kekayaan plasma nutfah perikanan yang tersebat di laut, pantai, tambak, kolam, danau, waduk, sungai dan perairan umum sangat beragam. Berbagai organisme tersebut jika dibudidayakan akan menjadi sumber ekonomi baru dan membuka lapangan kerja. Berkembangnya hatchery skala rumah tangga ikan hias terbukti mampu menggairahkan perekonomian desa. Penelitian pengelolaan plasma nutfah perikanan ini dimaksudkan untuk mengkaji jenis-jenis ikan dan udang yang potensial serta fauna endemik dan pola-pola pengelolaan dan budidaya yang dilakukan oleh masyarakat terutama di wilayah tiga kabupaten, yaitu : Sumenep, Kediri, dan Trenggalek. Dari kajian empiris banyak ditemukan spesies endemik yang potensial untuk dikembangkan menjadi unggulan daerah. Potensi perikanan tangkap dan budidaya di Kabupaten Sumenep dan Trenggalek masih terbuka lebar untuk dikembangkan. Budidaya ikan karang dan lobster perlu diimbangi dengan sistem perbenihan yang handal dan berkesinambungan. Budidaya rumput laut perlu didukung dengan sitem pemasaran. Ikan karang dan lobster diperdagangkan sebagian besar masih berasal dari tangkapan di alam. Budidaya kerapu dan lobster yang dilakukan di kepulauan juga masih mengandalkan benih dari alam dan sebagian keil saja yang menggunakan benih dari hatchery. Pola pengelolaan plasma nutfah perikanan bersifat spesies spesifik. Teknologi perbenihan ikan karang dan lobster belum banyak dikuasai masyarakat. Kesimpulannya adalah sumenep dan wilayah kepulauannya adalah gudang aneka ikan karang, lobster, rumput laut dan teri nasi. Trenggalek merupakan penghasil aneka ikan pelagis seperti tongkol, tuna, cakalang, tengiri dan teri galer. Kediri adalah gudang ikan hias terutama cupang dn koi serta benih aneka ikan air tawar. Potensi perikanan tangkap dan budidaya di kabupaten Sumenep dan Trenggalek masih terbuka lebar untuk dikembangkan.
PEMBERDAYAAN MASYARAKAT KELOMPOK USAHA KECIL MELALUI PROGRAM PEMBANGUNAN WILAYAH TERPADU ANTAR DESA (PPWTAD)
Authors: Sutrisno H. Edy 
Published: November 2018

Program Pembangunan Wilayah Terpadu Antar Desa (PPWTAD) adalah suatu program penanggulangan kemiskinan dengan pendekatan pemberdayaan masyarakat dan pengembangan wilayah yang dilakukan dengan memanfaatkan potensi-potensi sumberdaya perdesaan secara terpadu. Penulisan makalah ini bertujuan untuk mengetahui seberapa besar pengaruh Program Pembangunan Wilayah Terpadu Antar Desa terhadap kelompok masyarakat usaha kecil yang ada di desa obyek studi. Menurut ketentuan BPS, yang diambil adalah sesuai hasil dari pendataan yaitu dua desa yang berdekatan berkategori merah (miskin) dan berkategori kuning (mendekati miskin) dua desa yang saling berdekatan. Setiap desa diambil 10 kelompok dan setiap kelompok terdiri dari 10 orang. Dan pendanaannya untuk program pembangunan wilayah terpadu antar desa masing-masing desa lokasi maupun biaya operasionalnya bersumber dari APBD Provinsi Jawa Timur.
Détermination des réseaux de cristaux microscopiques. Application aux différentes formes du silicate tricalcique
Authors: Regourd Micheline 
Published: November 2018

La structure pseudo˗hexagonale du silicate tricalcique, à la température ambiante, est mise en évidence à l'aide de deux méthodes : construction du réseau réciproque d'un monocristal microscopique à l'aide d'un diagramme de cristal oscillant et d'un diagramme de Weissenberg puis méthode du pseudo˗réseau hexagonal grâce aux raies de poudre.
L'indexation des raies de diagrammes Debye˗Scherrer obtenus à l'aide d'une chambre à haute température a permis d'identifier six phases du silicate tricalcique entre la température ambiante et 1 100° soit :
Triclinique I →(à 620°) Triclinique II →(à 920°) Triclinique III →(à 980°) Monoclinique →(à 990°) Orthorhombique →(à 1 050°) Hexagonal
Ces transitions, confrontées avec celles de la micro˗analyse thermique différentielle, peuvent correspondre à des changements de symétrie ou à des surstructures.
A la température ambiante, la forme triclinique aurait les paramètres :
a = 28,16 Å b = 28,42 Å c = 25,10 Å
α = 90°10 β = 90°22 γ = 120°
ASTROSAT/UVIT Survey of M31, First Results: UV-bright Stars in the Bulge
Authors: Leahy Denis A. , Bianchi Luciana , Postma Joseph E. 
Published: November 2018

Abstract
A survey of M31 is being carried out with the ASTROSAT Observatory in ultraviolet (UV), soft X-rays, and hard X-rays using the UltraViolet Imaging Telescope (UVIT), soft X-ray telescope, LAXPC, and CZT instruments. Here we analyze UVIT observations of the first field covering the central (7′) part of the bulge of M31. The UV bands observed cover the range 120–280 nm with four filters with a spatial resolution of 1″. They are sensitive to the UV emission from hot stars (T
eff > 10000 K), so can be used to detect the hottest stars in the bulge of M31. We cross-match the UVIT sources with sources from Panchromatic Hubble Andromeda Treasury to obtain multi-band spectral energy distributions (SEDs) for 26 sources. Fits of the SEDs with stellar models show that these are likely main-sequence stars with masses in the range 5–20 M
⊙. This provides evidence for a low, but significant (∼10−5
M
⊙ yr−1), rate of star formation in the bulge of M31, which has occurred in the very recent past (∼10–100 million years).
Follow-up Imaging of Disk Candidates from the Disk Detective Citizen Science Project: New Discoveries and False Positives in WISE Circumstellar Disk Surveys
Authors: Silverberg Steven M. , Kuchner Marc J. , Wisniewski John P. , Bans Alissa S. , Debes John H. , Kenyon Scott J. , Baranec Christoph , Riddle Reed , Law Nicholas , Teske Johanna K. , Burns-Kaurin Emily , Bosch Milton K. D. , Cernohous Tadeas , Doll Katharina , Durantini Luca Hugo A. , Hyogo Michiharu , Hamilton Joshua , Finnemann Johanna J. S. , Lau Lily ,   Disk Detective Collaboration
Published: November 2018

Abstract
The Disk Detective citizen science project aims to find new stars with excess 22 μm emission from circumstellar dust in the AllWISE data release from the Wide-field Infrared Survey Explorer. We evaluated 261 Disk Detective objects of interest with imaging with the Robo-AO adaptive optics instrument on the 1.5 m telescope at Palomar Observatory and with RetroCam on the 2.5 m du Pont Telescope at Las Campanas Observatory to search for background objects at 0.″15–12″ separations from each target. Our analysis of these data leads us to reject 7% of targets. Combining this result with statistics from our online image classification efforts implies that at most 7.9% ± 0.2% of AllWISE-selected infrared excesses are good disk candidates. Applying our false-positive rates to other surveys, we find that the infrared excess searches of McDonald et al. and Marton et al. all have false-positive rates >70%. Moreover, we find that all 13 disk candidates in Theissen & West with W4 signal-to-noise ratio >3 are false positives. We present 244 disk candidates that have survived vetting by follow-up imaging. Of these, 213 are newly identified disk systems. Twelve of these are candidate members of comoving pairs based on Gaia astrometry, supporting the hypothesis that warm dust is associated with binary systems. We also note the discovery of 22 μm excess around two known members of the Scorpius–Centaurus association, and we identify known disk host WISEA J164540.79-310226.6 as a likely Sco-Cen member. Thirty of these disk candidates are closer than ∼125 pc (including 26 debris disks), making them good targets for both direct-imaging exoplanet searches.
Atlas of Cosmic-Ray-induced Astrochemistry
Authors: Albertsson Tobias , Kauffmann Jens , Menten Karl M. 
Published: November 2018

Abstract
Cosmic rays are the primary initiators of interstellar chemistry, and getting a better understanding of the varying impact they have on the chemistry of interstellar clouds throughout the Milky Way will not only expand our understanding of interstellar medium chemistry in our own galaxy, but also aid in extra-galactic studies. This work uses the ALCHEMIC astrochemical modeling code to perform numerical simulations of chemistry for a range of ionization rates. We study the impact of variations in the cosmic-ray ionization rate on molecular abundances under idealized conditions given by constant temperatures and a fixed density of 104 cm−3. As part of this study we examine whether observations of molecular abundances can be used to infer the cosmic-ray ionization rate in such a simplified case. We find that intense cosmic-ray ionization results in molecules, in particular the large and complex ones, being largely dissociated, and the medium becoming increasingly atomic. Individual species have limitations in their use as probes of the cosmic-ray ionization rate. At early times (<1 Myr) ions such as

and HOC+ make the best probes, while at later times, neutral species such as HNCO and SO stand out, in particular due to their large abundance variations. It is, however, by combining species into pairs that we find the best probes. Molecular ions such as

combined with different neutral species can provide probe candidates that outmatch individual species, in particular

,

, HOC+/O, and HOC+/HNCO. These still have limitations to their functional range, but are more functional as probes than as individual species.
Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals
Authors: Sarkar Surojit , Yuzefpolskiy Yevgeniy , Xiao Hanxi , Baumann Florian M. , Yim Soojin , Lee David J. , Schenten Dominik , Kalia Vandana 
Published: November 2018

Abstract
IL-1, generally considered an amplifier of adaptive immune responses, has been proposed for use as adjuvant during immunization with weak immunogens. However, its effects on memory T cell function remain largely undefined. Using the murine model of acute viral infection, in this paper, we show that in addition to augmenting the size of the Ag-specific pool, IL-1 signals act directly on CD8 T cells to promote the quality of effector and memory responses. Ablation of IL-1R1 or MyD88 signaling in T cells led to functional impairment; both the ability to produce multiple cytokines on a per cell basis (polyfunctionality) and the potential for recall proliferation in response to antigenic restimulation were compromised. IL-1 supplementation during priming augmented the expansion of Ag-specific CD8 T cells through the MyD88–IRAK1/4 axis, resulting in a larger memory pool capable of robust secondary expansion in response to rechallange. Together, these findings demonstrate a critical role of the IL-1–MyD88 axis in programming the quantity and quality of memory CD8 T cell responses and support the notion that IL-1 supplementation may be exploited to enhance adoptive T cell therapies against cancers and chronic infections.
THE CELLULAR CONTENT OF COWS MILK.
Authors: Smith J. W. , Schultze W. D. 
Published: November 2018

Summary
Cell counts and California Mastitis Test (CMT) scores were compared on 1,214 individual quarter samplings, Despite the fact that there was a high correlation (&gt;0.85) between CMT score and log of cell count, almost half (48.8%) of the quarters were misclassified by the CMT as compared to the cell counts obtained from Breed smears.
These data indicate that the CMT conducted on a single foremilk sample is a poor estimator of the inflammatory status of the quarter.