bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the role of perfectionism in contributing to internalizing symptoms in youth with juvenile idiopathic arthritis
Authors: Brandelli Yvonne N , Mackinnon Sean P , Chambers Christine T , Parker Jennifer A , Huber Adam M , Stinson Jennifer N , Johnson Shannon A , Wilson Jennifer P 
Published: November 2024

Abstract

Objective
Youth with juvenile idiopathic arthritis (JIA) experience elevated rates of internalizing symptoms, although more research is required to understand this phenomenon. Perfectionism, a multidimensional personality trait that involves dimensions such as striving for flawlessness (self-oriented perfectionism) and feeling that others demand perfection (socially-prescribed perfectionism), is a well-known risk factor for internalizing symptoms that has received minimal attention in pediatric populations. Preregistered hypotheses explored the relationships between youth and parent perfectionism and symptoms of depression and anxiety in youth with JIA, as mediated by (a) youth/parent negative self-evaluations and (b) youth self-concealment.

Methods
One hundred fifty-six dyads comprised of youth (13–18 years) with JIA and a caregiver completed online questionnaires about trait perfectionism, negative self-evaluations (i.e., pain catastrophizing and fear of pain), self-concealment, and internalizing symptoms.

Results
Positive relationships were observed between parent/youth self-oriented perfectionism and negative self-evaluations, youth self-oriented perfectionism and internalizing symptoms, and youth negative self-evaluations and internalizing symptoms. Parent self-oriented perfectionism was negatively related to youth depression symptoms. Indirect effects were observed for youth self-oriented perfectionism predicting anxiety and depression symptoms through pain catastrophizing (a1b1 = 0.13 and 0.12, 95% CI [.03, .24 and .03, .22], respectively). Exploratory mediations suggested youth socially-prescribed perfectionism might predict internalizing symptoms directly and indirectly through self-concealment.

Conclusion
Youth and parent perfectionism are implicated in the internalizing symptoms of youth with JIA and may manifest through youth negative self-evaluations (e.g., catastrophic thoughts) and self-concealment. While future research is needed, screening for perfectionistic tendencies in this population may help guide assessment, prevention, and treatment efforts.
Quantitative Particle Analysis of Neptunium-237 Oxides: Optimization of MAMA Analysis for Modified Direct Denitration Products
Authors: Parker Connor J , Peruski Kathryn M , Cary Samantha K 
Published: November 2024

Abstract
The production of plutonium-238 through irradiation of neptunium-237 (237Np) target materials for the use in radioisotope thermoelectric generators is paramount for continued deep space exploration. This work employs scanning electron microscopy to analyze 237Np materials coupled with a well-developed image analysis framework (Morphological Analysis for Material Attribution, or MAMA) to determine the degree of micron-scale homogeneity in the materials. This work demonstrated how the quantification of particle characteristics can validate production materials and affirm the qualitative similarities observed in micrographs. The 237Np oxide particle analysis determined that the materials from five production runs were quantitatively homogenous (significant at α = 0.05) in particle area, circularity, equivalent circular diameter, and ellipse aspect ratio, with two of the sampling dates having statistically significant different means for one of the four characteristics. These metrics not only confirm general homogeneity of the material but also expand the application of MAMA workflows to 237Np materials, demonstrating the utility of MAMA analysis for a wider breadth of nuclear materials than previously reported. In the open literature, this study is the first time that these microanalytical techniques were applied to 237Np materials to this degree.
Who will benefit from vorasidenib? Review of data from the literature and open questions
Authors: Darlix Amélie , Preusser Matthias , Hervey-Jumper Shawn L , Shih Helen A , Mandonnet Emmanuel , Taylor Jennie W 
Published: November 2024

Abstract
The clinical efficacy of isocitrate dehydrogenase (IDH) inhibitors in the treatment of patients with grade 2 IDH-mutant (mIDH) gliomas is a significant therapeutic advancement in neuro-oncology. It expands treatment options beyond traditional radiation therapy and cytotoxic chemotherapy, which may lead to significant long-term neurotoxic effects while extending patient survival. The INDIGO study demonstrated that vorasidenib, a pan-mIDH inhibitor, improved progression-free survival for patients with grade 2 mIDH gliomas following surgical resection or biopsy compared to placebo and was well tolerated. However, these encouraging results leave a wake of unanswered questions: Will higher-grade mIDH glioma patients benefit? When is the appropriate timing to start and stop treatment? Where does this new treatment option fit in with other treatment modalities? In this study, we review the limited data available to start addressing these questions, provide a framework of how to discuss these gaps with current patients, and highlight what is needed from the neuro-oncology community for more definitive answers.
“Treatable not curable”: trade-offs in the use of treatment-oriented language with patients who have incurable cancer
Authors: Batten Jason N , Kennedy Kristin M , Wong Bonnie O , Kraft Stephanie A , Hanks William , Magnus David , Schapira Lidia 
Published: November 2024

Abstract
Treatment-oriented language is used by physicians to convey to patients that treatment is available for their cancer (eg, “our usual treatment for this is…,” “we can treat this,” “your cancer is still treatable”). For patients who have incurable cancer, especially for patients with a poor prognosis or who are at the end of life, it is important to understand how physicians conceptualize and use this “everyday” clinical language. We conducted a qualitative interview study with a multidisciplinary group of physicians (n = 30) who may care for patients with cancer at different points in their clinical course, from diagnosis to end of life. Physicians report a wide range of reasons for using treatment-oriented language in conversations with patients who have incurable cancer. However, physicians also reported concerns that this language can be ambiguous, can convey unintended positive prognostic information, and can shift attention away from important matters such as the non-curative nature of treatment or the inevitability of death. On the basis of these concerns, physicians should (1) consider whether their aims in using treatment-oriented language can be better achieved using other evidence-based communication strategies, and (2) recognize and proactively mitigate potential adverse effects of treatment-oriented language, which may manifest much later in the patient’s clinical course.
Machine learning-based prediction of one-year mortality in ischemic stroke patients
Authors: Abujaber Ahmad , Yaseen Said , Imam Yahia , Nashwan Abdulqadir , Akhtar Naveed 
Published: November 2024

Abstract
Background: Accurate prediction of mortality following an ischemic stroke is essential for tailoring personalized treatment strategies. This study evaluates the effectiveness of machine learning models in predicting one-year mortality after an ischemic stroke. Methods: Five machine learning models were trained using data from a national stroke registry, with logistic regression demonstrating the highest performance. The SHapley Additive exPlanations (SHAP) analysis explained the model’s outcomes and defined the influential predictive factors. Results: Analyzing 8183 ischemic stroke patients, logistic regression achieved 83% accuracy, 0.89 AUC, and an F1 score of 0.83. Significant predictors included stroke severity, pre-stroke functional status, age, hospital-acquired pneumonia, ischemic stroke subtype, tobacco use, and co-existing diabetes mellitus (DM). Discussion: The model highlights the importance of predicting mortality in enhancing personalized stroke care. Apart from pneumonia, all predictors can serve the early prediction of mortality risk which supports the initiation of early preventive measures and in setting realistic expectations of disease outcomes for all stakeholders. The identified tobacco paradox warrants further investigation. Conclusion: This study offers a promising tool for early prediction of stroke mortality and for advancing personalized stroke care. It emphasizes the need for prospective studies to validate these findings in diverse clinical settings.
Complex patterns and determinants of regional multiple chronic conditions across the United States
Authors: Xu Yanqing , Yan Ming , Fu Cong , Xu Wei , Liu Yan , Li Yuchen 
Published: November 2024

Abstract
Noncommunicable chronic diseases (NCDs) are a rapidly growing global public health concern, posing substantial challenges to healthcare systems. The presence of multiple (≥2) chronic conditions (MCC) exacerbates these challenges. In this study, we constructed an integrated MCC network to comprehensively evaluate the impact of NCD prevalence and associated factors on MCC patterns. We identified four distinct MCC patterns, each with its unique set of associated risk factors. Firstly, we found that race, sedentary lifestyles, and smoking habits were significant contributors to the co-occurrence of diabetes, chronic kidney disease, and cancer. Secondly, smoking habits and mental health were identified as risk factors associated with the clusters of high cholesterol, hypertension, coronary heart disease, and arthritis. Furthermore, the comorbidity of chronic obstructive pulmonary disease and asthma was affected by socioeconomic status, smoking habits, and educational attainment, and a noteworthy reciprocal relationship existed between these two MCC combinations. Thirdly, the combination of asthma and obesity is associated with risk factors such as mental health, smoking habits, sedentary lifestyles, and binge drinking behaviors. Finally, the pattern of depression-stroke comorbidity was influenced by risk factors including mental health, age, and sleep duration. Our findings hold valuable implications for healthcare system optimization, offering a pathway to mitigate the escalating burden of NCDs. Additionally, they provide a foundation for scientific strategies aimed at the joint prevention and management of these complex conditions, ultimately enhancing public health and safety on a global scale.
Estimation of the ratio of exchangeable organically bound hydrogen to total organically bound hydrogen in flatfish flesh
Authors: Masuda Tsuyoshi , Kakiuchi Hideki , Ishikawa Yoshio , Tani Takashi 
Published: November 2024

Abstract
The exchangeability of hydrogen atoms within organic molecules in vivo with ambient water hydrogen is uncertain. We assessed this by administrating the tracer deuterium to the fish. Flatfish were retained in deuterium-elevated seawater for 48 h, and the deuterium-to-hydrogen (D/H) ratios in the flesh samples were measured. Rapid in vivo equilibration between exchangeable organically bound hydrogen (Ex-OBH) and tissue-free water (TFW) hydrogen was indicated by the linear relationship between the D/H ratios of total organically bound hydrogen (t-OBH) and TFW. The estimated ratio of Ex-OBH to t-OBH (fe) in vivo was 7.2 ± 0.0%, while there was no in vivo production rate of non-exchangeable organically bound deuterium (Nx-OBD). In contrast to this estimation of no production of Nx-OBD in vivo, the D/H values of Nx-OBH measured by equilibration in vitro increased, consequently reducing the value of fe in vitro to some extent compared to that of fe in vivo. This indicated that a certain portion of Ex-OBH in vivo was not exchangeable during the equilibration in vitro.
A summary of updated UNSCEAR evaluations on medical and occupational exposures to ionising radiation and call for participation in UNSCEAR Global Surveys on radiation exposure
Authors: Chen Jing 
Published: November 2024

Abstract
This paper summarises key findings of United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2020/2021 Report on the evaluations of medical and occupational exposures to ionising radiation. Medical exposure remains by far the largest human-made source of radiation exposure of the population. In the period 2009–18, about 4.2 billion medical radiological examinations were performed annually, resulting in an effective dose per caput of 0.57 mSv. The worldwide annual number of workers exposed to natural and human-made sources of ionising radiation is estimated to be ~24 million in the period 2010–14. About 52% of those were employed in the sectors that involve exposure to natural sources of radiation. The annual effective dose was estimated to be around 2.0 mSv for workers exposed to natural sources (excluding radon exposure in workplaces other than mines) and 0.5 mSv for workers exposed to human-made sources. It is important to motivate United Nations Member States to fully participate in UNSCEAR’s global surveys on radiation exposure. Future surveys will be relevant and useful and adapted to changing data sources and uses of radiation across the world.
Countermeasures and follow-up actions in response to information on thyroid cancer, which possibly provoked misunderstanding and unfounded rumour, issued by five former Japanese prime ministers
Authors: Amir Isamu , Ito Naomi , Tsubokura Masaharu 
Published: November 2024

Abstract
This study summarises the responses to information on thyroid cancer, which possibly provoked misunderstanding and unfounded rumour, described in a letter issued by five former Japanese Prime Ministers on 27 January, 2022. Fukushima Medical University (FMU) implemented countermeasures and follow-up in three phases in response to the letter. In Phase 1, FMU shared scientific facts on the relationship between radiation exposure and thyroid cancer, as well as the response of FMU towards those who read the letter and were concerned about the description. Furthermore, FMU organised lectures and workshops to facilitate peer support among medical and non-medical staff, which were publicised through a newspaper article. In Phase 2, the peer support programme targeting patients with thyroid cancer was launched. In Phase 3, FMU participated in a TV programme to explain the medical aspects of thyroid cancer and the importance of providing peer support to patients with cancer, featuring individuals with experiences as medical staff and survivors.
Involvement of cellular senescence in the effect of X-irradiated human lung fibroblast WI-38 cells on human lung cancer A549 cell clonogenic potential
Authors: Yoshino Hironori , Tadano Katsuki , Omiya Chinatsu , Ishii Kae , Munakata Nanami 
Published: November 2024

Abstract
Ionizing radiation not only affects irradiated but also non-irradiated surrounding cells through intercellular communication, indicating that the former cells could affect the latter. The present study investigated the effect of X-irradiated normal human lung fibroblast WI-38 cells on the clonofenic potential of human lung cancer A549 cells by co-culturing them. Moreover, the relationship between the effects of co-culturing on the clonogenic potential of A549 cells and cellular senescence in WI-38 cells was investigated. The co-culture with 10-Gy-irradiated WI-38 cells and A549 cells enhanced the clonogenic potential of non- or X-irradiated A549 cells. Irradiated WI-38 cells exhibited high SA-β-gal activity, a cellular senescence hallmark. Importantly, treatment with senolytic drugs, which eliminate senescent cells, not only influenced high-SA-β-gal-activity cell percentages among the irradiated WI-38 cells but also the effect of irradiated WI-38 cells on the clonogenic potential of A549 cells. In conclusion, our results suggest that irradiated WI-38 cells promote A549 cell clonogenic potential and irradiated senescent WI-38 cells contribute to this effect.
Investigating the association between dry deposition of cesium and different growth stages of aboveground parts of Chinese yam
Authors: Imada Shogo , Kawabata Hitoshi , Yanai Masumi 
Published: November 2024

Abstract
Radiocesium released into the atmosphere from accidents at nuclear facilities, can be deposited on the surface of the surrounding crop fields as dry and wet deposits. Radiocesium deposition can occur at any time during the growth season. In this study, we used stable cesium (Cs) to investigate the changes in dry Cs deposits on surfaces of aboveground parts of Chinese yam (Dioscorea polystachya) during different growth stages. Chinese yam seedlings were grown for eight different lengths of time and were then simultaneously exposed to aerosol particles containing stable Cs in an aerosol exposure chamber for 5 h. The deposition density of Cs on the aboveground parts of the seedlings decreased from 29 to 72 d after transplantation (DAT) and did not change significantly after 72 DAT. The Cs deposition density on the seedlings on different DAT correlated with the leaf area available for the deposition of aerosol Cs particles.
Practical cut-off value for radon concentration in indoor air using an activated-charcoal radon collector
Authors: Yasuoka Yumi , Takemoto June , Omori Yasutaka , Kawamoto Nanaho , Goda Nao , Nagahama Hiroyuki , Muto Jun , Tokonami Shinji , Hosoda Masahiro , Iimoto Takeshi , Mukai Takahiro 
Published: November 2024

Abstract
The World Health Organization (WHO) recommends that countries adopt the reference level of 100 Bq m−3 for indoor radon gas. Adopting the reference level requires a preliminary assessment of the indoor radon concentration. In the preliminary investigation, a cut-off value is useful, which is a value for selecting samples that can be reliably determined to be below the reference level (in this paper, the WHO reference level) using a straightforward method. If the true value was the WHO reference level, then the cut-off value of the PicoRad collector for selecting samples was determined as 80 Bq m−3 through the analysis of the 95% prediction interval.
Analysis of cellular effects by continuous exposure AT low concentration of tritium
Authors: Isobe Rio , Suzuki Masatoshi , Endo Satoru , Kino Yasushi , Ishikawa Ryoya , Inaba Yohei , Fukumoto Manabu , Chida Koichi 
Published: November 2024

Abstract
This study investigated the induction of DNA double-strand breaks (DSBs) in the hTERT-immortalized normal human diploid epithelial cells (RPE1-hTERT) continuously exposed to 6000 Bq/ml of tritiated water (HTO) and organically bound tritium (OBT). The relationship of the DSBs induction with the intracellular amount as well as the localization of tritium was also examined. Tritium-labeled thymidine (3H-Thy) and palmitic acid (3H-PA) were used as OBT. The average number of DSBs, which were indicated as co-localized foci of 53BP1 with phosphorylated H2AX, per cell was higher in the order of treatments with 3H-Thy, 3H-PA, and HTO. This order was consistent with that of tritium localization in the insoluble nuclear fraction but not with the intracellular amount of tritium. In addition to the intracellular amount of tritium, we showed that the subcellular localization of tritium is an important factor in cellular effects stimulated by DSBs.
Development of evaluation method for radiocesium availability in soil by biomimetic approach
Authors: Takeda Akira , Unno Yusuke , Swallow Mathew J B , Yagasaki Yasumi , Yasutaka Tetsuo , Akata Naofumi 
Published: November 2024

Abstract
Applicability of biomimetic approach with simulation of plant uptake for assessment of radiocesium availability in soil was investigated. The soil spiked with 137Cs tracer was contacted with wicking material and copper-substituted prussian blue (Cu-PB), which simulate transpirationally induced mass flow and concentration gradient-induced diffusion of radiocesiumin the soil, respectively. Comparison of the removed 137Cs to the wick and the wick + Cu-PB from the soil during the contact period of 12 weeks suggested that the diffusion process has larger contribution than the mass flow process in radiocesium dynamics in root zone. The change of the removed rate of 137Cs from the soil was reflected that its availability decreased with the time elapsing and with subjecting repeated wet-dry treatment. The results suggest that the biomimetic approach can be applicable to the realistic evaluation of the availability of radiocesium in soil.
Occupational radiation dose among student radiographers, nuclear medicine technologists, and radiotherapists in an Australian university
Authors: Deb Pradip 
Published: November 2024

Abstract
To become registered radiation worker as radiographer, nuclear medicine (NM) technologist, or radiotherapist in Australian health system, a 4-y bachelor’s degree, or a 2-y master’s degree in medical imaging (MI), NM, or radiation therapy (RT) approved by the Australian Health Practitioner Regulation Agency is required. During their supervised clinical practice period, it is crucial to monitor students’ occupational radiation dose as their annual dose limit is 1 mSv y−1 unlike regular occupational dose of 20 mSv y−1. In this study, the distribution and trend of occupational dose among over 300 radiography, NM, and radiotherapy student practitioners per year in an Australian university are analyzed over a period of 10 y (2013–22). The overall average annual effective dose was well below the dose limit set for the students. Among the three streams—MI, NM, and RT—NM students had the highest annual dose.
I have seen this before: imprinting experiences and Bank CEO risk-taking in times of crisis
Authors: Jung Jiwook , Pernell Kim , Shin Taekjin 
Published: November 2024

Abstract
Understanding the causes and consequences of corporate risk-taking has remained a crucial topic for organizational scholars. Using the case of U.S. banks and one dimension of their risk-taking behavior around the 2008 financial crisis, we offer a theory of how the diverse experiences of corporate leaders can shape their risk-taking behavior. Building on the imprinting literature, we theorize how different types of experiences that bank CEOs had in the past interact to shape current risk-taking behavior, resulting in risk moderation under crisis conditions. We focus on two imprinting experiences with particular relevance for bank CEOs’ risk-taking behavior—MBA education and past crisis experience. We argue that the latter played a pronounced role during the crisis because of greater imprint-environment fit. Our analysis using data from 170 large banks between 2001 and 2019 shows that bank CEOs’ firsthand experience of a prior banking crisis not only directly tempered bank risk-taking but also did so indirectly by limiting the risk-taking tendencies of CEOs with an MBA, particularly during the crisis period. Our study contributes to the sociological literature about organizational risk-taking by emphasizing the crucial role of organizational leaders’ biographies and exploring how earlier institutional conditions shape their risk-taking behavior later.