bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative hypoalbuminemia was associated with acute kidney injury in high-risk patients following non-cardiac surgery: a retrospective cohort study
Authors: Li Nan , Qiao Hong , Guo Jing-Fei , Yang Hong-Yun , Li Xue-Ying , Li Shuangling , Wang Dong-Xin , Yang Li 
Published: June 2019

Abstract
Background: Acute kidney injury (AKI) is a common complication following non-cardiac surgery with adverse short- and long- term morbidity and mortality. Evidence shows that hypoalbuminemia is associated with increased AKI risk in patients with infectious diseases and cancer and following cardiac surgery and transplant surgery. However, little evidence is available on non-cardiac surgery population. Thus, we investigated the association between preoperative hypoalbuminemia and AKI following non-cardiac surgery.
Methods: We retrospectively assessed perioperative risk factors and preoperative serum albumin concentration in 729 consecutive adult patients who underwent non-cardiac surgery from July 1, 2017, to June 30, 2018. Each patient was categorized according to maximal Kidney Disease Improving Global Outcomes criteria based on creatinine changes and urine output within the first week after surgery. Multivariate Logistic regression models were used to analyze the association between preoperative hypoalbuminemia and postoperative AKI.
Results: Of 729 patients, 188 (25.8%) developed AKI. AKI incidence was higher in patients with preoperative serum albumin <37.5 g/L than in those with preoperative serum albumin ≥37.5 g/L [35.9% (98/273) vs. 19.7% (90/456), P<0.001]. Multivariate logistic regression analysis showed that preoperative serum albumin <37.5 g/L (odds ratio 1.892; 95% confidence interval 1.238-2.891; P=0.003) was independently associated with postoperative AKI. Patients with preoperative serum albumin <37.5 g/L tended to have a higher but not significant ratio in AKI stage 2 (2.6% vs 1.1%, P=0.144) and much higher ratio in AKI stage 3 (4.8% vs 0.7%, P<0.001) than those with preoperative serum albumin ≥37.5 g/L. AKI patients had a higher in-hospital mortality rate [6.9% (13/188) vs. 0.2% (1/541), P<0.001]. Kaplan-Meier analysis revealed that the cumulative survival rate decreased with increasing AKI severity (P<0.001). Postoperative AKI was also associated with other worse outcomes, such as prolonged mechanical ventilation [53.4 (33.0, 73.8) vs 14.7 (11.1, 18.3) hours, P<0.001], intensive care unit stay [4.0 (3.1, 4.9) vs 2.0 (1.8, 2.3) days, P<0.001], postoperative hospital stay [17.8 (14.8, 20.9) vs 12.3 (11.3, 13.3) days, P<0.001], and higher total cost [13,453 (8,538, 20,228) vs 11,306 (6,277, 16,400) dollars, P<0.001].
Conclusions: Preoperative hypoalbuminemia was independently associated with AKI after non-cardiac surgery, and postoperative AKI was associated with poor outcomes.
Exploring the druggable space around the Fanconi anemia pathway using machine learning and mechanistic models
Authors: Esteban-Medina Marina , Peña-Chilet María , Loucera Carlos , Dopazo Joaquin 
Published: June 2019

Abstract
Background

In spite of the abundance of genomic data, predictive models that describe phenotypes as a function of gene expression or mutations are difficult to obtain because they are affected by the curse of dimensionality, given the disbalance between samples and candidate genes. And this is especially dramatic in scenarios in which the availability of samples is difficult, such as the case of rare diseases.

Results

The application of multi-output regression machine learning methodologies to predict the potential effect of external proteins over the signaling circuits that trigger Fanconi anemia related cell functionalities, inferred with a mechanistic model, allowed us to detect over 20 potential therapeutic targets.

Conclusions

The use of artificial intelligence methods for the prediction of potentially causal relationships between proteins of interest and cell activities related with disease-related phenotypes opens promising avenues for the systematic search of new targets in rare diseases.
Nutrient removal in hybrid constructed wetlands: spatial-seasonal variation and the effect of vegetation
Authors: Abbasi Haq Nawaz , Xie Jing , Hussain Syed Ikhlaq , Lu Xiwu 
Published: June 2019

Abstract
Constructed wetlands (CWs) are an aesthetic and sustainable form to treat wastewater, however, their performance can be increased by improving a number of factors. The pilot-scale hybrid constructed wetland (CW) system was the combination of constructed floating treatment wetlands (CFWs) and horizontal subsurface flow constructed wetlands (HSFCWs); operated for a year and covered all seasons. The research was conducted to investigate the performance of the CW system regarding water depth, spatial, and seasonal removal of pollutants. Nine economical plants species were selected and divided into four groups to grow in CW-I to CW-IV, respectively. Removal increased along the bed and most of the total phosphorus (TP) removal occurred in the second bed, whereas total nitrogen (TN) and ammonium (NH4) removal were associated with the plant root system and biomass. Optimum removal of nutrients with respect to water depth was at 35 cm. TN and NH4 removal patterns were similar in different CWs. TN and NH4 removal were higher during summer compared to winter; only CW-IV showed the opposite trend.
Galectin-3 and Arterial Stiffness in Patients with Heart Failure: A Pilot Study
Authors: Oikonomou Evangelos , Karlis Dimitris , Tsalamadris Sotiris , Siasos Gerasimos , Chrysohoou Christina , Vogiatzi Georgia , Dimitropoulos Stathis , Charalambous Georgios , Kouskouni Evangelia , Tousoulis Dimitris 
Published: June 2019

Background:
Cardiac performance depends on optimum ventriculoarterial coupling which is
impaired in patients with heart failure (HF). Galectin-3 is a mediator of myocardial fibrosis and remodeling,
and is associated with clinical status in patients with chronic HF. We examined the association of
arterial stiffness with galectin-3 levels in patients with HF of ischemic etiology.

Methods:
We consecutively enrolled 40 patients with stable ischemic HF and reduced ejection fraction.
Central aortic stiffness was evaluated non-invasively by measuring carotid femoral pulse wave velocity
(PWV). Among other factors, serum levels of galectin-3 and b-type natriuretic peptide (BNP) were
measured.

Results:
The median galectin-3 levels in our study population were 12.9 (10.8-18.7) ng/ml and the mean
PWV was 9.31±2.79 m/sec. There was significant association of galectin-3 levels with age (r=0.48,
p=0.003), creatinine clearance (r=-0.66, p<0.001) and BNP levels (r=0.36, p=0.05). There was a significant
association of galectin-3 levels with PWV (r=0.37, p=0.03) and patients with PWV above median
also had significantly increased levels of galectin-3 compared with patients with lower values of PWV
[16.1(11.8-25.2) vs. 12.1(10.5-14) ng/ml, p=0.03].

Conclusion:
We found an association of arterial stiffness and PWV with galectin-3 levels in patients
with chronic HF of ischemic etiology. These findings suggest a pathway driving arterial stiffening and
myocardial remodelling in HF. This may provide insight into the mechanism determining prognosis and
clinical status of patients with HF.
ZIF@ZnTiO3 Nanocomposite as a Reusable Organocatalyst for the Synthesis of 3, 4-dihydropyrano[c]chromene Derivatives
Authors: Farahmand Taybeh , Hashemian Saeedeh , Shibani Ali 
Published: June 2019

Background:Dihydropyrano [3, 2-c]chromenes and their derivatives have great attention for scientists. They have different activities such as biological properties, spasmolytic, diuretic, anticoagulant, anti-cancer, and anti-anaphylactic activity. For these vary biological activities, chromene derivatives have made significant for further progress in medicinal and organic synthesis studies. So, in view of the importance of chromenes, we aimed to synthesis of 3, 4-dihydropyrano [3, 2-c] chromene derivatives. ZIF@ZnTiO3nanocomposite as organocatalyst was used.Method:An effective and applicable technique was used for preparation of 3, 4-dihydropyrano [3, 2- c] chromene derivatives. Dihydropyrano [c] chromenederivatives were prepared by using ZIF@ZnTiO3compositeas a recyclable catalyst. One-pot three-component reaction of aromatic aldehydes, malononitrile, and 4-hydroxycoumarin was done for synthesis of dihydropyrano [c] chromenederivatives over composite catalyst with excellent yields. The as prepared dihydropyrano [c] chromenederivatives were measured by melting point, FTIR, 1H NMR, and 13C NMR. The nano catalyst could be recycled several times.Result:A novel nano catalyst of MOF containing Mn2+ ions and 2- methyl imidazole (ZIF) and zinctitanate (ZIF@ZnTiO3) composite was prepared. The synthesized organocatalyst was studied for preparation of 3, 4-dihydropyrano [3, 2-c] chromene derivatives. One-pot three-component reaction of aromatic aldehydes, malononitrile, and 4-hydroxycoumarin was done for synthesis of dihydropyrano [c] chromene derivatives over composite catalyst with excellent yields. The reaction was optimized.Conclusion:The organocatalyst composite of consist of ZIF and zinctitanate was prepared. The ZIF@ZnTiO3 was used as catalyst for synthesis of 3, 4-dihydropyrano [3, 2-c] chromene derivatives via one-pot three-component condensations of aromatic aldehydes,malononitrile, and 4 hydroxycoumarin. The results of melting point, FTIR, 1H NMR, 13C NMR also confirmed the formation of high yield of 3, 4-dihydropyrano [3, 2-c] chromene derivatives at short time. The appealing properties of this method are environmentally friendly, mild reaction conditions (low reaction time and high yields of pure products), easy work up and recyclability of reaction catalyst.
Avaliação de programas de intervenção para a aprendizagem socioemocional do professor: Uma revisão integrativa
Authors: Marques Alcione Moreira , Tanaka Luiza Hiromi , Foz Adriana Queiroz Botelho 
Published: June 2019

A profissão docente gera grande demanda emocional, o que pode afetar o bem-estar do professor e gerar problemas de saúde. As competências socioemocionais envolvem um conjunto de habilidades, conhecimentos e atitudes para reconhecer e lidar melhor com as próprias emoções e com a dimensão emocional dos alunos, o que pode diminuir o estresse e aumentar a qualidade da prática do professor. A aprendizagem socioemocional pode aumentar os recursos internos e a competência para lidar melhor com as demandas profissionais. Nesta revisão integrativa da literatura buscou-se levantar nas principais bases de dados mundiais (SCOPUS, PubMed, ERIC, SciELO, Web of Science, Campbell Collaboration) os estudos realizados sobre programas de intervenção específicos para desenvolver as competências socioemocionais do professor do ensino básico, suas características e impactos ou efeitos no professor. Foram incluídos 18 artigos sobre estudos que tiveram como objetivo a aprendizagem socioemocional do próprio professor, não associados a programas voltados aos alunos. Concluiu-se que embora haja poucos estudossobre o tema, todos apresentaram impactos ou efeitos positivos no aumento de habilidades socioemocionais, na saúde, bem-estar, ou na eficácia docente.
Palavras-chave:Professor; Aprendizagem socioemocional; Estresse;Revisão integrativa
The Attitudes of Therapists and Physicians on the Use of Sex Robots in Sexual Therapy: Online Survey and Interview Study
Authors: Eichenberg Christiane , Khamis Marwa , Hübner Lisa 
Published: June 2019

Background
Various types of robots have already been successfully used in medical care, and the use of new technologies is also playing an increasing role in the area of sexuality. Sex robots are marketed as advanced sex toys and sex dolls with artificial intelligence. Only a few considerations about the therapeutic use of sex robots in sexual therapy are debated in expert discussions.

Objective
The aim of this study was to conduct a first exploratory survey on the attitudes of sex therapists and physicians toward the therapeutic benefits of sex robots.

Methods
This study comprised a quantitative online survey and a qualitative interview study. A self-constructed questionnaire was used to survey the general attitudes of sex therapists and physicians regarding the benefits of sex robots in therapy. The qualitative study was designed to gain in-depth insight into the participants’ beliefs and attitudes. Therefore, semistructured interviews were conducted. The quantitative data were evaluated by statistical analysis, and the interviews were transcribed and analyzed by using a grounded theory approach.

Results
A total of 72 sex therapists and physicians completed our self-constructed questionnaire (response rate 15%, 72/480). Only a few respondents (11%, 8/72) said that the use of sex robots was not conceivable for them, and almost half of all therapists and physicians could imagine recommending sex robots in therapy (45%, 33/72). The attitude toward sex robots as a therapeutic tool was very heterogeneous, with gender (P=.006), age (P=.03), and occupational differences (P=.05); female therapists, older therapists, and psychologists (in contrast to physicians) were more critical toward the therapeutic use of sex robots. The analysis of the 5 interviews identified 3 high-level core themes that were representative of the participants’ responses: (1) the importance of the personal definition of sex robots for the assessment of their therapeutic benefits, (2) therapeutic benefits and dangers of sex robots, and (3) considerations on the quality of human-robot sexuality. Initial insights into the possible therapeutic use of sex robots in different disorders (eg, sexual dysfunction or pedophilia) and situations were gained from the perspective of sex therapists.

Conclusions
The results of this study provide a first overview of the potential therapeutic use of sex robots. Moral, ethical, and treatment-related issues in this context are still unresolved and need to be further researched. We suggest integrating the topic into the training of sex therapists to form opinions beyond media images and to show therapy possibilities. Scientists engaged in sexual research should be involved in the development of sex robots to design robots with positive effects on sexual education, sexual therapy, sexual counseling, and sexual well-being for interested groups.
Do Daily Fluctuations in Psychological and App-Related Variables Predict Engagement With an Alcohol Reduction App? A Series of N-Of-1 Studies
Authors: Perski Olga , Naughton Felix , Garnett Claire , Blandford Ann , Beard Emma , West Robert , Michie Susan 
Published: June 2019

Background
Previous studies have identified psychological and smartphone app–related predictors of engagement with alcohol reduction apps at a group level. However, strategies to promote engagement need to be effective at the individual level. Evidence as to whether group-level predictors of engagement are also predictive for individuals is lacking.

Objective
The aim of this study was to examine whether daily fluctuations in (1) the receipt of a reminder, (2) motivation to reduce alcohol, (3) perceived usefulness of the app, (4) alcohol consumption, and (5) perceived lack of time predicted within-person variability in the frequency and amount of engagement with an alcohol reduction app.

Methods
We conducted a series of observational N-of-1 studies. The predictor variables were measured twice daily for 28 days via ecological momentary assessments. The outcome variables were measured through automated recordings of the participants’ app screen views. A total of nine London-based adults who drank alcohol excessively and were willing to set a reduction goal took part. Each participant’s dataset was analyzed separately using generalized additive mixed models to derive incidence rate ratios (IRRs) for the within-person associations of the predictor and outcome variables. Debriefing interviews, analyzed using thematic analysis, were used to contextualize the findings.

Results
Predictors of the frequency and amount of engagement differed between individuals, and for the variables 'perceived usefulness of the app' and 'perceived lack of time', the direction of associations also differed between individuals. The most consistent predictors of within-person variability in the frequency of engagement were the receipt of a daily reminder (IRR=1.80-3.88; P<.05) and perceived usefulness of the app (IRR=0.82-1.42; P<.05). The most consistent predictors of within-person variability in the amount of engagement were motivation to reduce alcohol (IRR=1.67-3.45; P<.05) and perceived usefulness of the app (IRR=0.52-137.32; P<.05).

Conclusions
The utility of the selected psychological and app-related variables in predicting the frequency and amount of engagement with an alcohol reduction app differed at the individual level. This highlights that key within-person associations may be masked in group-level designs and suggests that different strategies to promote engagement may be required for different individuals.
Development of a Rubric to Assess Lifelong Learning in Work-Integrated Learning Reflection Assignments
Authors: Sproule Robert , Drewery Dave , Pretti Judene 
Published: June 2019

Lifelong learning has emerged as an important learning outcome across the Canadian post-secondary education system. However, assessments of lifelong learning have been limited to students’ self-reports, particularly questionnaires. In programs that offer work-integrated learning experiences, students’ reflections may provide a window to further developing this outcome. The purpose of this study was to develop a rubric for assessing lifelong learning in this context. A review of the literature was used to develop both a rubric and self-assessment instrument for measuring lifelong learning. Students in an accounting and financial management co-op program at a Canadian university (n = 32) completed the self-assessment and the rubric was applied to two reflection assignments. Staff feedback and correlational analyses provide initial support for the rubric as a useful tool for assessing lifelong learning. Implications for educators especially in work-integrated learning contexts are addressed.
Keywords: lifelong learning, reflection, rubric, work-integrated learning

L’apprentissage permanent est devenu un objectif d’apprentissage important dans l’ensemble du système d’éducation postsecondaire canadien. Toutefois, l’évaluation de l’apprentissage permanent s’est limitée jusqu’à maintenant aux témoignages des étudiants, au moyen de questionnaires tout particulièrement. Dans les programmes qui offrent des expériences d’apprentissage intégrées au milieu du travail, les réflexions des étudiants peuvent représenter une occasion de progrès dans ce domaine. L’objectif de notre étude était de concevoir une grille d’évaluation permettant d’évaluer l’apprentissage permanent dans un tel contexte. En nous fondant sur un examen des études existantes, nous avons élaboré cette grille ainsi qu’un outil d’auto-évaluation afin d’évaluer l’apprentissage permanent. Des étudiants inscrits dans un programme d’alternance travail-études en comptabilité et gestion financière d’une université canadienne (n = 32) ont complété l’auto-évaluation et nous avons appliqué la grille d’évaluation à deux devoirs d’ordre réflexif. Les commentaires du personnel et l’analyse des corrélations semblent de prime abord indiquer que la grille d’évaluation est un outil utile pour évaluer l’apprentissage permanent. Nous discutons des conséquences de notre étude pour les éducateurs, tout spécialement dans le contexte de l’apprentissage intégré au milieu de travail.

Mots clés : apprentissage permanent, réflexion, grille d’évaluation, apprentissage intégré au milieu de travail
Lived Experiences of Online and Experiential Learning in Four Undergraduate Professional Programs
Authors: Snow Kathy , Wardley Leslie , Carter Lorrraine , Maher Pat 
Published: June 2019

This paper presents the observations and reflections of four faculty members who developed experiential online learning pathways for students in diverse professional programs. In relation to programmatic expectations of Nursing, Education and Business, the challenges and opportunities for experiential online learning design are discussed. In addition, the scaffolding and development of online learning within an undergraduate degree, which ladders into professional programing, are presented. Using Kolb’s Experiential Model of learning design to structure the discussion, the faculty members reflect on the success of implementation from their various positions as leaders and instructors of programs. They seek to answer questions for themselves and their faculties in relation to the feasibility of designing experiential learning opportunities online and how this can contribute to deepening professional practice. The paper closes with implications for practice for other post-secondary educators who may be considering experiential online learning.

Notre article présente les observations et les réflexions de quatre enseignants qui ont mis au point des parcours d’apprentissage expérientiel en ligne pour des étudiants inscrits dans divers programmes professionnels. Nous discutons des difficultés et des possibilités de l’apprentissage expérientiel en ligne par rapport aux attentes des programmes de soins infirmiers, d’éducation et de commerce. De plus, nous présentons la construction et l’élaboration de l’apprentissage en ligne dans un programme de premier cycle universitaire qui conduit à l’élaboration de programmes professionnels. En utilisant le modèle expérientiel de conception de l’apprentissage de Kolb pour structurer la discussion, les enseignants réfléchissent aux réussites dans la mise en œuvre de leurs différentes fonctions de chefs de programme et d’instructeurs. Ils se posent des questions – pour leur propre compte et pour les enseignants – sur la faisabilité de la conception d’apprentissages expérientiels en ligne et se demandent comment cela peut contribuer au perfectionnement de leur pratique professionnelle. Nous nous penchons enfin sur les conséquences de notre étude pour la pratique d’autres éducateurs, au niveau postsecondaire, qui envisagent peut-être l’apprentissage expérientiel en ligne.