bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary Early Glycation Products Promote the Growth of Prostate Tumors More than Advanced Glycation End‐Products through Modulation of Macrophage Polarization
Authors: Chen Yingjia , Guo Tai L. 
Published: December 2018

ScopeGlycation products are ubiquitous in food at high concentrations in the Western diet. The well‐controlled glycation resulting in the production of early glycation products (EGPs) has been proposed as a strategy to improve the physicochemical properties of food proteins. However, the health effects of EGPs are unknown. It has been shown that the Western diet (glycation prone) is associated with a higher mortality in prostate cancer (PCa) patients than the prudent diet; therefore, the role of EGPs in prostate tumorigenesis is investigated.Methods and resultsC57BL/6 male mice are treated with the vehicle (water), non‐reacted samples, EGPs, and advanced glycation end‐products (AGEs) by gavage. EGPs (600 mg kg−1 body weight per day) promoted the growth of subcutaneously transplanted TRAMP‐C2 PCa cells the most among these groups. Significantly, increases in the circulation monocytes and tumor‐associated M2 macrophages are observed in EGP‐treated mice, and the M2/M1 ratio is also increased in the EGP group when compared to that of water and AGEs. In the human PCa cell and macrophage co‐cultures, EGPs increase the spheroid size, and importantly, macrophages are also polarized toward M2.ConclusionsEGPs induce the proliferation of PCa cells either directly or by assisting PCa cells to polarize macrophages toward M2.
A 167‐to‐172 GHz 65‐nm CMOS body‐voltage‐tuned harmonic‐mode voltage‐controlled oscillator
Authors: Jain Sanjeev , Zhang Nan , Belostotski Leonid 
Published: December 2018

Abstract
This article presents a mm‐wave harmonic‐mode varactor‐free 167‐to‐172‐GHz oscillator that features improved output power and tuning range. The parasitic capacitor of the cross‐coupled pair is adjusted for frequency tuning via the body‐bias technique, thus eliminating the need for varactors of conventional mm‐wave voltage‐controlled oscillators (VCOs). The output of the proposed VCO is at the 2nd‐harmonic and is tunable from 167 to 172 GHz, while its dc power consumption ranges between 13.5 and 21 mW, respectively. The proposed circuit was designed and implemented using TSMC 65‐nm 1P9M CMOS technology, with a total chip size of 0.22 × 0.35 mm2. The output power of the proposed VCO is −10.5 dBm at 169.8 GHz with 13.5 mW dc power consumption, and its maximum dc‐to‐RF efficiency is 0.48%.
Dual‐polarized planar lens antenna designed with a quad‐ridged frequency selective surface
Authors: Moy‐Li Hon Ching , Sánchez‐Escuderos Daniel , Antonino‐Daviu Eva , Ferrando‐Bataller Miguel 
Published: December 2018

AbstractThis letter presents a microwave planar lens illuminated by a radially corrugated horn antenna. The lens is formed by a set of 5×5 multilevel unit cells working as a frequency selective surface. Each layer of the unit cells is formed by a square metallic ring with two sets of orthogonal stubs. The length of each set of stubs controls the transmission phase shift for each polarization, so that the lens can be configured independently for two orthogonal polarizations. The lens presented in this letter makes use of this operation to compensate the phase profile of the radiation pattern generated by the feeder. A prototype, with the lens located at 0.59
λ from the feeder, has been fabricated. Measured results show a maximum gain above 14.44 dBi within the operating frequency band (12.55‐13.10 GHz), and a crosspolar level below −32 dB within the HPBW.
A power efficient impulse generator for 6‐9 GHz UWB applications
Authors: Jang Won Il , Choi Woon Sung , Kong Tong Ook , Park Myung Cheol , Eo Yun Seong 
Published: December 2018

AbstractThis article presents a VCO‐based impulse generator, in which all circuit blocks are switched for low power consumption. A switching control pulse generator is employed for adjusting the impulse duration. The drive amplifier can generate triangular‐like impulse with high amount of side‐lobe rejection without any external filter. The experimental results show that the frequency range covers 6.5‐9.3 GHz and 10‐dB bandwidth is tunable from 0.5‐2 GHz, while consuming only 39.6 pJ/pulse at 10 MHz pulse repetition frequency. The impulse generator is fabricated using a 0.13 μm CMOS process and chip size is 1.07 × 1.50 mm2 including ESD pads.
A Yagi‐Uda antenna array for conformal IoT and wireless charging applications
Authors: Raad Haider 
Published: December 2018

AbstractIn this article, a flexible Yagi‐Uda antenna array is presented. The array comprises 4 radiating elements and operates at 5 GHz. The design is aimed at integration within Multiple Input Multiple Output (MIMO)‐based Internet of Things (IoT) and wireless charging platforms that require mechanical flexibility. The array elements are positioned back to back in a cross fashion to achieve a pattern diversity utilizing the end‐fire radiation characteristics of such high gain antennas. This technique in turn reduces the mutual coupling between the array elements which is crucial to the performance of MIMO systems. Each single element is printed on a 50.8 μm Kapton Polyimide substrate and consists of a driven (fed) element and three parasitic directors. The simulated and measured scattering parameters show that the proposed array achieves a reasonable impedance bandwidth and isolation performance (S12 < −31 dB) at resonance.
Simultaneous qualitative and quantitative evaluation of Toddalia asiatica root by using HPLC‐DAD and UPLC‐QTOF‐MS/MS
Authors: Zhu Mingjuan , Wei Pinqing , Peng Qian , Qin Shengying , Zhou Yuan , Zhang Ren , Zhu Chenchen , Zhang Lei 
Published: December 2018

AbstractIntroductionCoumarin and alkaloids are the major bioactive constituents of Toddalia asiatica, playing an important role in various biological activities such as anti‐inflammatory, analgesic, anti‐bacterial and anti‐tumour.ObjectiveTo establish a method that will simultaneously determine the coumarins and alkaloids compounds in T. asiatica and identify their characteristic fragmentation patterns, while combining fingerprints and chemical identification with chemometrics for discrimination and quality assessment of T. asiatica samples.MethodologyQualitative characterisation of coumarins and alkaloids compounds in the methanol extracts of T. asiatica was determined by ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry (UPLC‐QTOF‐MS/MS). Quantitative analysis relies on high‐performance liquid chromatography with a diode array detector (HPLC‐DAD).ResultsA total of 59 components were characterised by UPLC‐QTOF‐MS/MS, including 29 coumarin, 25 alkaloids, one phenolic acid and four flavonoids. While the 19 characteristic components out of 23 common peaks in the chromatographic fingerprints of T. asiatica were confirmed. Quantitative analysis of seven major compounds from 18 samples were simultaneously detected by HPLC‐DAD at wavelengths of 280 nm. The samples were classified into three groups by hierarchical clustering analysis (HCA) combined with principal component analysis (PCA), and orthogonal partial least squares discriminant analysis (OPLS‐DA) which screened out the main chemical markers responsible for the samples differences.ConclusionFingerprints combined with chemometrics and chemical identification are a simple, rapid and effective method for the quality control of T. asiatica.
School psychologists’ interprofessional collaboration with medical providers: An initial examination of training, preparedness, and current practices
Authors: Arora Prerna G. , Levine Jamie L. , Goldstein Thalia R. 
Published: December 2018

AbstractResearch has pointed to the importance of interprofessional collaboration (IPC) between school psychologists and medical providers in the provision of quality mental health care for youth with chronic health conditions. However, little is known about current IPC practices among school psychologists. This study examined school psychology trainees’ and professionals’ perceptions of training, preparedness, and current practices related to IPC with medical providers. Survey results indicated that participants (N = 317) endorse relatively low levels of training and preparedness and limited practice of IPC with medical providers. Additionally, results indicated that perceptions of training and preparedness were associated with current practices in IPC with medical providers. Findings demonstrated the impact of training and preparedness on subsequent engagement in IPC and have implications for the future training of school psychologists as they seek to address the needs of youth with chronic health conditions.
Field‐grown soybean transcriptome shows diurnal patterns in photosynthesis‐related processes
Authors: Locke Anna M. , Slattery Rebecca A. , Ort Donald R. 
Published: December 2018

AbstractMany plant physiological processes have diurnal patterns regulated by diurnal environmental changes and circadian rhythms, but the transcriptional underpinnings of many of these cycles have not been studied in major crop species under field conditions. Here, we monitored the transcriptome of field‐grown soybean (Glycine max) during daylight hours in the middle of the growing season with RNA‐seq. The analysis revealed 21% of soybean genes were differentially expressed over the course of the day. Expression of some circadian‐related genes in field‐grown soybean differed from previously reported expression patterns measured in controlled environments. Many genes in functional groups contributing to and/or depending on photosynthesis showed differential expression, with patterns particularly evident in the chlorophyll synthesis pathway. Gene regulatory network inference also revealed seven diurnally sensitive gene nodes involved with circadian rhythm, transcription regulation, cellular processes, and water transport. This study provides a diurnal overview of the transcriptome for an economically important field‐grown crop and a basis for identifying pathways that could eventually be tailored to optimize diurnal regulation of carbon gain.
Interventions to promote adherence to endocrine therapy among breast cancer survivors: A meta‐analysis
Authors: Finitsis David J. , Vose Brittany A. , Mahalak Justin G. , Salner Andrew L. 
Published: December 2018

AbstractObjectiveAdjuvant endocrine therapy (AET) significantly reduces risk of breast cancer recurrence in those patients whose tumor tests hormone (estrogen and/or progesterone) receptor positive. Many who are prescribed AET do not adhere adequately. Studies have sought to examine the effects of interventions to enhance patients' AET adherence, with strikingly mixed results. In order to reconcile a disparate literature, this paper aims to (1) quantitatively review the aggregate effect of interventions designed to optimize AET adherence within the current literature and (2) meta‐analyze these effects across studies' by intervention design.MethodsDuplicate searches were conducted using multiple electronic databases as well as hand searches of recent year conference abstracts. Studies were included that (1) tested an intervention to promote AET adherence; (2) reported at least one measure of medication adherence; and (3) reported (or provided upon request) data sufficient to calculate effect size. Effect sizes were calculated using random effects models.ResultsSeven studies representing eight unique interventions were included. We observed an overall null effect across all interventions (k = 8;d[95% CI] = 0.28 [−0.05, 0.61]); however, sensitivity analyses showed that interventions that used bi‐directional communication showed statistically significant effects relative to control groups within each study (k = 4;d[95% CI] = 0.59 [0.23, 0.95]) while those relying only on providing information to the patient (one‐way communication) did not (k = 4;d[95% CI] = −0.03 [−0.27, 0.20]).ConclusionsInterventions that promote patient self‐report may improve AET adherence through enhancing patient engagement. Investigators and clinicians who wish to optimize medication adherence in this population can consider this approach.
Physicians' attitudes towards psycho‐oncology, perceived barriers, and psychosocial competencies: Indicators of successful implementation of adjunctive psycho‐oncological care?
Authors: Senf Bianca , Fettel Jens , Demmerle Christina , Maiwurm Paula 
Published: December 2018

AbstractObjectiveClinical experience reveals a gap between recommended psychosocial care and actual support for psycho‐oncology. Physicians are essential for managing psychosocial distress and for the successful implementation of psycho‐oncology. The aim was to explore physician's attitudes towards psycho‐oncology, their self‐perceived barriers towards referral to psycho‐oncology, and their personal psychosocial competencies in a maximum‐care hospital.MethodSemistructured interviews informed the development of a questionnaire administered to a monocentric sample of 120 physicians at the University Hospital Frankfurt. The data were exploratively analysed.ResultsOne hundred two physicians completed the questionnaire. Physicians provided high ratings concerning the value of psycho‐oncology, beliefs about its efficacy, and their personal commitment to psycho‐oncology. Physicians noticed especially barriers that originated from patients themselves. They estimated their own psychosocial education and knowledge as moderate but rated their psychosocial skills and abilities as higher. Frequency of integration of psychosocial care was most strongly influenced by physicians' psychosocial competencies and their personal commitment to psycho‐oncology. Integration of psycho‐oncological issues occurs in 43% of patients.ConclusionPhysicians are an important indicator of successful implementation. The discrepancy between the positive evaluation and actual support for psycho‐oncology may be explained by several factors, eg, the lack of support from clinic leaders. Patient‐related barriers, most often identified by physicians, seem to be an indication of actual lack of psychosocial competencies. Physicians' psychosocial competencies positively affect the implementation of psycho‐oncology. Sound knowledge of psychosocial topics may result in increased integration of psychosocial aspects into treatment. Therefore, medical training should focus more on psychosocial issues.
Nanoscale Imaging and Stabilization of Silica Nanospheres in Liquid Phase Transmission Electron Microscopy
Authors: Meijerink Mark J. , Spiga Cristiano , Hansen Thomas W. , Damsgaard Christian D. , de Jong Krijn P. , Zečević Jovana 
Published: December 2018

AbstractLiquid phase transmission electron microscopy (LP‐TEM) is a novel and highly promising technique for the in situ study of important nanoscale processes, in particular the synthesis and modification of various nanostructures in a liquid. Destabilization of the samples, including reduction, oxidation, or dissolution by interactions between electron beam, liquid, and sample, is still one of the main challenges of this technique. This work focuses on amorphous silica nanospheres and the phenomena behind their reshaping and dissolution in LP‐TEM. It is proposed that silica degradation is primarily the result of reducing radical formation in the liquid phase and the subsequent accelerated hydroxylation of the silica, while alterations in silica solid structure, pH, and oxidizing species formation had limited influence. Furthermore, the presence of water vapor instead of liquid water also results in degradation of silica. Most importantly however, it is shown that the addition of scavengers for reducing radicals significantly improved amorphous silica stability during LP‐TEM imaging. Devising such methods to overcome adverse effects in LP‐TEM is of the utmost importance for further development and implementation of this technique in studies of nanoscale processes in liquid.
The vorticity of the current density tensor and 3D‐aromaticity
Authors: Barquera‐Lozada José Enrique 
Published: December 2018

AbstractThe induced current density (J(r)) vector field has been extensively used as a criterion of aromaticity and electron delocalization. However, the selection of the direction of the perturbing magnetic field (B) is arbitrary and in the case of three‐dimensional electron delocalization/aromaticity the selection could be ambiguous. The J(r) has also recently received some criticism as an aromaticity index. We propose the Trace of the Vorticity of the Current Density tensor (TVCD) scalar field as a more suitable quantity for the evaluation of electron delocalization of three‐dimensional systems. It does not depend on the orientation of B and contrary to other related scalar fields like the anisotropy of the induced current density, it does not lose the information of the direction of the currents. We show that not only the currents parallel to the molecular plane are important in the evaluation of the aromaticity, as is largely believed, but also the perpendicular ones, which information is included in the TVCD. The TVCD is very useful to study planar and 3D delocalized molecules (eg, fullerenes). Moreover, the integration of the TVCD over an internal surface of the 3D‐cages serves as index for 3D‐aromaticity.
Derivatization‐free method for compound‐specific isotope analysis of nonexchangeable hydrogen of 4‐bromophenol
Authors: Kuder Tomasz , Bernstein Anat , Gelman Faina 
Published: December 2018

RationaleCompound‐specific isotope analysis (CSIA) is a valuable tool in environmental chemistry and in other fields of science. Currently, hydrogen CSIA of polar compounds containing exchangeable hydrogen is uncommon. To extend the scope of CSIA applications, we present an alternative method of analysis, bypassing the typical step of derivatization. The method is demonstrated for two environmental contaminants, 4‐bromophenol (4BP) and 2,4,6‐tribromophenol (TBP).MethodsNet isotope ratios obtained by CSIA combine the isotope composition of nonexchangeable, carbon‐bound hydrogen and the exchangeable hydroxyl hydrogen. To constrain the isotope composition of the latter, an ethyl acetate solution of 4BP or TBP injected into the IRMS instrument was amended with excess water of known isotope composition. The results were calibrated using bracketing control samples analyzed in sequence with the unknown samples and the known isotope ratios of water present in ethyl acetate solution.ResultsThe analytical precision was comparable to the precision for halogenated compounds without exchangeable hydrogen, analyzed using similar instrumentation. The isotope ratios of the bromophenols correlated with the isotope composition of the water in the sample matrix, suggesting that the hydroxyl group of the target compound remained close to the equilibrium with the sample water during the passage through the instrument. Based on this relationship, the signatures of the nonexchangeable hydrogen were obtained using the isotope composition of sample water as the proxy for the isotope composition of the target compound hydroxyl group.ConclusionsThe developed method could be adopted to analysis of other low molecular weight compounds amenable to gas chromatography without the absolute need for derivatization. Currently, the method can be used for samples from laboratory experiments, with high concentrations of the target compound to provide mechanistic insight into the degradation mechanisms. Further work would be required to optimize the method to low concentration environmental samples.
Addition of divalent iron to electron donor mixtures for remediation of chlorinated ethenes: A study of 100 wells
Authors: Davis Doug , Miller Owen J. 
Published: December 2018

AbstractThe objective of this study is to assess the effects of adding soluble divalent iron (DVI) to emulsified electron donor mixtures to promote the biogeochemical destruction of four common chlorinated ethenes—perchloroethylene, trichloroethylene, cis‐1,2‐dichloroethylene, and vinyl chloride (VC)—as part of electron donor mixture enhanced reductive dechlorination treatments in groundwater. Twenty‐four project sites were studied, comprising 100 performance monitoring wells across the U.S. Wells that received DVI treatment showed increased dechlorination rates, improved contaminant reduction, and limited daughter product formation relative to the wells that did not receive DVI treatment. Following injection of electron donor treatments and DVI, the time required for a well to reach 90% reduction from a peak concentration was improved for the 25, 50, and 75% confidence intervals for the four chlorinated ethenes studied relative to an approach using electron donor mixture treatments alone. The total improvement in time to degrade chlorinated ethenes through VC was also improved. Daughter product formation was also less for wells where DVI was added to the electron donor mixture. The cost to add a DVI amendment was less than $3 per cubic yard as applied.
Accumulation of arsenic and antimony in Aloe barbadensis: A transplantation study
Authors: Ong Ghim Hock , Cheng Wan Hee , Wong Ling Shing 
Published: December 2018

AbstractArsenic (As) and antimony (Sb) accumulation in medicinal plants is a serious health issue, especially in common plants such as Aloe barbadensis. The accumulation of As and Sb in A. barbadensis is assessed in this study by transplanting A. barbadensis in a control and contaminated soil plot. Samples of A. barbadensis and surface soils from both control (Nilai, Malaysia) and polluted (Klang, Malaysia) sites were collected and analyzed for heavy metals using neutron activation analysis. Indices used to assess the anthropogenic input of this study were the index of geoaccumulation (Igeo) and enrichment factor (EF), while the metals uptake of the plant were determined using the bioconcentration factor (BCF) and translocation factor (TF). Overall, Klang soils showed higher As and Sb concentrations compared to Nilai. The EF of As were 19.38 for Nilai and 28.07 for Klang while the EF of Sb was 18.01 for Nilai and 29.12 for Klang. These values indicated significant enrichment (EF: 5–20) for Nilai and moderate enrichment (EF: 20–50) for Klang. The Igeo values for As were 3.25 (Nilai) and 3.89 (Klang) while the Igeo values for Sb were 3.14 (Nilai) and 3.94 (Klang), which fell under the category of “strongly polluted” (Igeo: 3–4). The BCF for As ranged from 0.05 to 0.07 while Sb was recorded at 0.07, indicating only small amounts of As and Sb were transferred from the soil to the roots. TF for As ranged from 0.29 to 0.67 while TF for Sb ranged from 0.51 to 0.89, showing a high percentage of metals transfer from roots to shoots. This study concluded that As and Sb levels in A. barbadensis were not harmful for human consumption.