bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erfassung der pneumologisch-fachärztlichen Versorgungsstrukturen für Patienten mit interstitiellen Lungenerkrankungen in Nordrhein-Westfalen
Authors: Hagmeyer L. , Haidl P. , Westhoff M. , Schulte W. , Randerath W. , Lorenz J. 
Published: May 2018

Zusammenfassung
Ziel der Studie Erfassung der Versorgungsrealität von interstitiellen Lungenerkrankungen (ILD) in Nordrhein-Westfalen.
Methodik Die Westdeutsche Gesellschaft für Pneumologie erfasste ILD-Schwerpunktstandorte mittels postalischer Abfrage. Struktur- und Prozessqualität wurden in einem Fragebogen evaluiert.
Ergebnisse 49 Standorte wurden registriert, 46 stellten ihre Standortdaten zur Verfügung (15 Facharztpraxen, 34 pneumologische Krankenhausabteilungen). Im Median werden in den Praxen im Jahr 360 ILD-Patienten gesehen (26 % Erstdiagnosen), in den Krankenhäusern 105 ILD-Patienten (63 % Erstdiagnosen). 10 Standorte stellen über 100 ILD-Erstdiagnosen pro Jahr. Die Praxen berichten im Median 50 Bronchoskopien im Jahr, die Krankenhäuser im Median 1396. 78 % der Standorte partizipieren an einer interdisziplinären ILD-Fallkonferenz.
Schlussfolgerung In Nordrhein-Westfalen existieren mehrere ILD-Versorgungsstandorte mit hoher Expertise. Ambulant erfolgt v. a. das Monitoring von ILD-Patienten, stationär werden eher komplexe ILD-Erstabklärungen oder ungewöhnliche Verläufe betreut. Standorte mit einem realen regionalen ILD-Versorgungsauftrag sollten in ihrer Weiterentwicklung gefördert werden.
Need For Long-Term Care in Children is Increasingly Caused by Disorders of Psychological Development. Changes in the Care Causing Diagnoses According to German Social Code (SGB XI) Between 2009–2014
Authors: Beck-Ripp Julia Christiane , Dressel Holger 
Published: May 2018

Abstract
Aim of the study There is an ongoing discussion on the increasing number of children with mental and developmental disorders, with some even needing long-term care according to the German Social Code XI. This study was performed to identify the main diagnoses justifying such care in children and to analyse their prevalence over time.
Methods The diagnoses justifying long-term care were evaluated using care assessments of Bavarian children and adolescents between 2009 to 2014 by the medical service of statutory health insurance.
Results Over the years investigated, the percentage of assessments due to a mental and behavioural disorder rose significantly from 36.2 to 42.2%. Since 2012, the most common diagnose changed from Down's syndrome to pervasive developmental disorders with marked increase of also mixed specific developmental disorders. In new applications for nursing insurance services the proportion of pervasive developmental disorders rose gradually from 151 in 2010 to 254 in 2014. During the whole period of time, the overall care dependency in children seemed to be stable.
Conclusions These observations might rather be influenced by altered awareness of health and illness, increasing readiness to seek help with psychological or developmental impairments as well as changed diagnostic criteria than by a steady increase in affected individuals.
Assistierte Heimdialyse
Authors: Kitsche Benno 
Published: May 2018

ZusammenfassungStellen wir uns gleich zu Beginn folgende selbstkritische Frage: Können wir im Zuge des demografischen Wandels unsere Patienten noch adäquat und nach ihren
Bedürfnissen behandeln? Schon jetzt und im Hinblick auf die zu erwartende Entwicklung der ansteigenden Zahl dialysepflichtiger Patienten bei gleichzeitiger
Abnahme der Zahl an nephrologischem Fachpersonal (Ärzte und Pflegekräfte) wird es höchste Zeit, Strukturen zu entwickeln, die mögliche alternative
Versorgungsformen unterstützen. Hier wäre zu diskutieren, ob bereits regional erprobte Versorgungsmodelle wie die assistierte Dialyse in der Umsetzung mit
interdisziplinären Teams flächendeckend ausgebaut werden sollten.
Treatment of Single Cords in Dupuytren Disease with Collagenase Clostridium Histolyticum: Study of a Cohort with Follow-up at 1 Year
Authors: Manent Bistué Ignasi , Suau Mateu Sonia , López Louzao Ana Maria , Caputo Pier Claudio , Rodriguez Roiz Víctor , De Villasante Jirón Ignasi , Del Valle Jou Montserrat 
Published: May 2018

Objective The purpose of the present work was to assess the effectiveness of collagenase Clostridium histolyticum in patients with Dupuytren disease with single cords and assess the recurrence rate in the first year after the treatment.
Material and Methods In this classic cohort study, a total of 53 patients (50 of them male) with a mean age of 68 years were studied who had been diagnosed with Dupuytren disease located in the metacarpophalangeal joint, in single cords, with more than 40° of extension loss. They were given an injection of collagenase C. histolyticum and later manipulation under locoregional anesthesia. The loss of extension was evaluated after a week and at the 1st, 3rd, 6th and 12th months. The effectiveness was analyzed with basis on the results of the Student t-test for paired data, as well as those of the effect size (ES) test.
Results An important and statistically significant correlation was found for the loss of cord extension in the metacarpophalangeal joint (t = 32.113; p < 0.01; ES = 4.11; standardized response mean [SRM] = 4.15).
Conclusion Collagenase is an injectable treatment, which is not very aggressive compared with surgery and is effective for the loss of extension in the metacarpophalangeal region secondary to single cord in Dupuytren disease during the first year.
Adequacy of Fixed-Dose Heparin Infusions for Venous Thromboembolism Prevention after Microsurgical Procedures
Authors: Prazak Ann , Agarwal Jayant , Goodwin Isak , Rockwell W. , Pannucci Christopher , Bertolaccini Corinne 
Published: May 2018

Background In microvascular surgery, patients often receive unfractionated heparin infusions to minimize risk for microvascular thrombosis. Patients who receive intravenous (IV) heparin are believed to have adequate prophylaxis against venous thromboembolism (VTE). Whether a fixed dose of IV heparin provides detectable levels of anticoagulation, or whether the “one size fits all” approach provides adequate prophylaxis against VTE remains unknown. This study examined the pharmacodynamics of fixed-dose heparin infusions and the effects of real-time, anti-factor Xa (aFXa) level driven heparin dose adjustments.
Methods This prospective clinical trial recruited adult microvascular surgery patients placed on a fixed-dose (500 units/h) unfractionated heparin infusion during their initial microsurgical procedure. Steady-state aFXa levels, a marker of unfractionated heparin efficacy and safety, were monitored. Patients with out-of-range aFXa levels received protocol-driven real-time dose adjustments. Outcomes of interest included aFXa levels in response to heparin 500 units/h, number of dose adjustments required to achieve goal aFXa levels, time to reach goal aFXa level, and 90-day clinically relevant bleeding and VTE.
Results Twenty patients were recruited prospectively. None of 20 patients had any detectable level of anticoagulation in response to heparin infusions at 500 units/h. The median number of dose adjustments required to reach goal level was five, and median weight-based dose to reach goal level was 11.8 units/kg/h. Real-time dose adjustments significantly increased the proportion of patients with in-range levels (60 vs. 0%, p = 0.0001). The 90-day VTE rate was 5% and 90-day clinically relevant bleeding rate was 5%.
Conclusions Fixed-dose heparin infusions at a rate of 500 units/h do not provide a detectable level of anticoagulation after microsurgical procedures and are insufficient for the majority of patients who require VTE prophylaxis. Weight-based heparin infusions at 10 to 12 units/kg/h deserve future study in patients undergoing microsurgical procedures to increase the proportion of patients receiving adequate VTE prophylaxis.
The geometric blueprint of perovskites
Authors: Filip Marina R. , Giustino Feliciano 
Published: May 2018

Significance
Perovskites constitute one of the most versatile and chemically diverse families of crystals. In perovskites the same structural template supports a staggering variety of properties, from metallic, insulating, and semiconducting behavior to superconducting, ferroelectric, ferromagnetic, and multiferroic phases. Approximately 2,000 perovskites are currently known. In this work we revisit the century-old model proposed by Goldschmidt to predict the formability of perovskites in the key of modern inferential statistics and internet data mining. We demonstrate that the nonrattling rule postulated by Goldschmidt can predict the stability of perovskites with a success rate of 80%. Using this tool we predict the existence of 90,000 hitherto unknown perovskites.
Wireless, intraoral hybrid electronics for real-time quantification of sodium intake toward hypertension management
Authors: Lee Yongkuk , Howe Connor , Mishra Saswat , Lee Dong Sup , Mahmood Musa , Piper Matthew , Kim Youngbin , Tieu Katie , Byun Hun-Soo , Coffey James P. , Shayan Mahdis , Chun Youngjae , Costanzo Richard M. , Yeo Woon-Hong 
Published: May 2018

Significance
We introduce a soft, low-profile, intraoral electronics that offers continuous real-time monitoring of sodium intake via long-range wireless telemetry. The stretchable, hybrid electronic system integrates chip-scale components and microstructured sodium sensors with stretchable interconnects, together in an ultrasoft, breathable, microporous membrane. The quantitative computational and experimental studies of antenna performance optimize the wireless electronics, offering consistent functionality with minimal loss during multimodal deformation. Examples of in vivo study with human subjects demonstrate a highly sensitive, real-time quantification of sodium intake.
Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation
Authors: Cheng Yu-Che , Shieh Sheau-Yann 
Published: May 2018

Significance
It has been known for some time that ATM and RAD3-related kinase (ATR) phosphorylates and activates checkpoint kinase 1 (CHK1) in response to DNA damage. However, how CHK1 is targeted to chromatin and how it is released has not been fully deciphered. Previously we demonstrated that CHK1 K63-linked ubiquitination contributes to its chromatin association and activation. The study presented here highlights the involvement of ubiquitin-specific protease 3 (USP3) in removing the K63-linked ubiquitin chain, thus allowing not only the release of CHK1 from chromatin but also the access of its substrates. Together our studies have revealed a stepwise regulation of CHK1 in DNA damage response.
Physics of lumen growth
Authors: Dasgupta Sabyasachi , Gupta Kapish , Zhang Yue , Viasnoff Virgile , Prost Jacques 
Published: May 2018

Significance
The development of intercellular cavities (lumens) is a ubiquitous mechanism to form complex tissue structures in organisms. The generation of Ciona Notochord, the formation of Zebrafish vasculature, or the formation of bile canaliculi between hepatic cells constitute a few examples. Lumen growth is governed by water intake that usually results from the creation of a salt concentration difference (osmotic gradients) between the inside and the outside of the lumen. During morphogenesis or in diseases, lumens can also leak due to improper maturation of the cell junctions that seal them. In this paper, we theoretically describe different conditions and dynamical regimes of lumen growth based on the balance of osmotic pressure, fluid intake, and paracellular leak.
Precise detection of de novo single nucleotide variants in human genomes
Authors: Gómez-Romero Laura , Palacios-Flores Kim , Reyes José , García Delfino , Boege Margareta , Dávila Guillermo , Flores Margarita , Schatz Michael C. , Palacios Rafael 
Published: May 2018

Significance
The precise location of variants in the human genome is of utmost importance. We present a unique approach, coverage-based single nucleotide variant (SNV) identification (COBASI), which uses only perfect matches between the reads of a sequence project and a reference genome to detect and accurately identify de novo SNVs. From the perfect matches, a representation of the read coverage per nucleotide along the genome, the variation landscape, is generated. SNVs are then pinpointed as significant changes in coverage and de novo SNVs can be identified with high precision. The performance of COBASI was analyzed using simulations and experimentally validated by sequencing de novo SNVs identified from a parent–offspring trio. We propose this pipeline as a useful tool for different genomic applications.
Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress
Authors: Xu Sujuan , Huang Shizheng , Luan Zhilin , Chen Tingyue , Wei Yuanyi , Xing Miaomiao , Li Yaqing , Du Chunxiu , Wang Bing , Zheng Feng , Wang Nanping , Guan Youfei , Gustafsson Jan-Åke , Zhang Xiaoyan 
Published: May 2018

Significance
As a ligand-activated transcription factor, farnesoid X receptor (FXR) is abundantly expressed in the liver and small intestine, where it plays an important role in the maintenance of bile acid, lipid, and glucose homeostasis. Increasing evidence is emerging that FXR may be a critical regulatory factor in renal physiology and pathophysiology. The present study demonstrates an essential role of FXR in promoting cell survival of medullary collecting duct cells under hypertonic stress and identifies FXR-induced TonEBP expression and activation as an underlying mechanism. This work provides an insight into the role of FXR in renal urine concentration.
Genomic integration of ERRγ-HNF1β regulates renal bioenergetics and prevents chronic kidney disease
Authors: Zhao Juanjuan , Lupino Katherine , Wilkins Benjamin J. , Qiu Chengxiang , Liu Jian , Omura Yasuhiro , Allred Amanda L. , McDonald Caitlin , Susztak Katalin , Barish Grant D. , Pei Liming 
Published: May 2018

Significance
Renal epithelial cells (RECs) contain abundant mitochondria that are essential to support renal reabsorption of electrolytes, glucose, and amino acids. However, it remains poorly understood how mitochondrial metabolism is coordinated with kidney reabsorptive functions. Here we show that deletion of estrogen-related receptor gamma (ERRγ) in RECs results in severe renal mitochondrial and reabsorptive dysfunction with fluid-filled cysts. ERRγ directly regulates mitochondrial metabolism and cooperates in regulating renal reabsorption genes with hepatic nuclear factor 1 beta (HNF1β), mutations of which cause strikingly similar renal dysfunction and cysts in animals and humans. These findings reveal a role for ERRγ in simultaneously coordinating a transcriptional program of renal energy-generating mitochondrial and energy-consuming reabsorptive functions relevant to kidney disease.
Electrical Properties of an m × n Hammock Network*
Authors: Tan Zhen , Tan Zhi-Zhong , Zhou Ling 
Published: May 2018

Abstract

Electrical property is an important problem in the field of natural science and physics, which usually involves potential, current and resistance in the electric circuit. We investigate the electrical properties of an arbitrary hammock network, which has not been resolved before, and propose the exact potential formula of an arbitrary m × n hammock network by means of the Recursion-Transform method with current parameters (RT-I) pioneered by one of us [Z. Z. Tan, Phys. Rev. E
91
(2015) 052122], and the branch currents and equivalent resistance of the network are derived naturally. Our key technique is to setting up matrix equations and making matrix transformation, the potential formula derived is a meaningful discovery, which deduces many novel applications. The discovery of potential formula of the hammock network provides new theoretical tools and techniques for related scientific research.
Utilization of Formal Support Services for Elder Abuse: Do Informal Supporters Make a Difference?
Authors: Burnes David , Breckman Risa , Henderson Charles R , Lachs Mark S , Pillemer Karl 
Published: May 2018

Abstract

Background and Objectives
Few elder abuse (EA) victims ever seek or receive assistance from formal support services designed to mitigate risk and harm of revictimization. This study examined whether the presence of third-party “concerned persons” in victims’ personal social networks plays a role in enabling formal support service utilization.

Research Design and Methods
A representative population-based survey administered to adults (n = 800) in New York State identified 83 EA cases from the past year. Penalized likelihood logistic regression was used to examine the relationship between availability of a concerned person and victim formal support services usage.

Results
EA victims who had a concerned person in their personal life were significantly more likely to use formal EA support services than victims without a concerned person. EA victims who lived with their perpetrator were significantly less likely to use formal services.

Discussion and Implications
Third-party concerned persons represent a critical population to target in efforts designed to promote EA victim help-seeking.
BPX preconditioners for isogeometric analysis using analysis-suitable T-splines
Authors: Cho Durkbin , Vázquez Rafael 
Published: May 2018

Abstract
We propose and analyse optimal additive multilevel solvers for isogeometric discretizations of scalar elliptic problems for locally refined T-meshes. Applying the refinement strategy in Morgenstern & Peterseim (2015, Analysis-suitable adaptive T-mesh refinement with linear complexity. Comput. Aided Geom. Design, 34, 50–66) we can guarantee that the obtained T-meshes have a multilevel structure and that the associated T-splines are analysis suitable, for which we can define a dual basis and a stable projector. Taking advantage of the multilevel structure we develop two Bramble-Pasciak-Xu (BPX) preconditioners: the first on the basis of local smoothing only for the functions affected by a newly added edge by bisection and the second smoothing for all the functions affected after adding all the edges of the same level. We prove that both methods have optimal complexity and present several numerical experiments to confirm our theoretical results and also to compare the practical performance of the proposed preconditioners.
A semismooth Newton method with analytical path-following for the $H^1$-projection onto the Gibbs simplex
Authors: Adam L , Hintermüller M , Surowiec T M 
Published: May 2018

Abstract
An efficient, function-space-based second-order method for the $H^1$-projection onto the Gibbs simplex is presented. The method makes use of the theory of semismooth Newton methods in function spaces as well as Moreau–Yosida regularization and techniques from parametric optimization. A path-following technique is considered for the regularization parameter updates. A rigorous first- and second-order sensitivity analysis of the value function for the regularized problem is provided to justify the update scheme. The viability of the algorithm is then demonstrated for two applications found in the literature: binary image inpainting and labeled data classification. In both cases, the algorithm exhibits mesh-independent behavior.
Earnings Losses and Labor Mobility Over the Life Cycle
Authors: Jung Philip , Kuhn Moritz 
Published: May 2018

AbstractLarge and persistent earnings losses following displacement have adverse consequences for the individual worker and the macroeconomy. Leading models cannot explain their size and disagree on their sources. Two mean-reverting forces make earnings losses transitory in these models: search as an upward force allows workers to climb back up the job ladder, and separations as a downward force make nondisplaced workers fall down the job ladder. We show that job stability at the top rather than search frictions at the bottom is the main driver of persistent earnings losses. We provide new empirical evidence on heterogeneity in job stability and develop a life-cycle search model to explain the facts. Our model offers a quantitative reconciliation of key stylized facts about the U.S. labor market: large worker flows, a large share of stable jobs, and persistent earnings shocks. We explain the size of earnings losses by dampening the downward force. Our new explanation highlights the tight link between labor market mobility and earnings dynamics. Regarding the sources, we find that over 85% stem from the loss of a particularly good job at the top of the job ladder. We apply the model to study the effectiveness of two labor market policies, retraining and placement support, from the Dislocated Worker Program. We find that both are ineffective in reducing earnings losses in line with the program evaluation literature.
The many Faces of Human Sociality: Uncovering the Distribution and Stability of Social Preferences
Authors: Bruhin Adrian , Fehr Ernst , Schunk Daniel 
Published: May 2018

AbstractWe uncover heterogeneity in social preferences with a structural model that accounts for outcome-based and reciprocity-based social preferences and assigns individuals to endogenously determined preferences types. We find that neither at the aggregate level nor when we allow for several distinct preference types do purely selfish types emerge, suggesting that other-regarding preferences are the rule and not the exception. There are three temporally stable other-regarding types. When ahead, all types value others' payoffs more than when behind. The first, strongly altruistic type puts a large weight on others' payoffs even when behind and displays moderate levels of reciprocity. The second, moderately altruistic type also puts positive weight on others' payoff, yet at a lower level, and displays no positive reciprocity. The third, behindness averse type puts a large negative weight on others' payoffs when behind and is selfish otherwise. In addition, we show that individual-specific estimates of preferences offer only very modest improvements in out-of-sample predictions compared to our three-type model. Thus, a parsimonious model with three types captures the bulk of the information about subjects' social preferences.