bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symptom importance, patient expectations, and satisfaction in chronic rhinosinusitis
Authors: Mattos Jose L. , Rudmik Luke , Schlosser Rodney J. , Smith Timothy L. , Mace Jess C. , Alt Jeremiah , Soler Zachary M. 
Published: February 2019

BackgroundSinonasal symptoms and poor quality of life (QOL) prompt chronic rhinosinusitis (CRS) patients to undergo sinus surgery (ESS). However, little is known regarding the symptoms most important to patients and how these impact expectations and postoperative satisfaction.MethodsA prospective, multi‐institutional cohort study of 100 CRS patients undergoing ESS completed a novel adaptation of the 22‐item Sino‐Nasal Outcome Test (SNOT‐22) wherein they rated how important it was for specific symptoms to improve after surgery, along with preoperative expectations and postoperative satisfaction. The primary satisfaction measure was whether a patient would choose to undergo endoscopic sinus surgery (ESS) again. A multivariate, logistic regression model was built using demographics, objective measures, and the adapted SNOT‐22 data. Spearman correlation analysis was also performed.ResultsNasal obstruction was rated as “extremely” or “very” important by 93% of patients, followed by smell/taste, thick nasal discharge, need to blow nose, postnasal discharge, and sleep symptoms (range, 61‐72%). Symptoms like sadness and embarrassment were not considered important by preoperative patients (≤28%). In multivariate logistic regression, postoperative satisfaction depended on preoperative expectations being met and ESS improving their most important symptoms (odds rato, 19.6‐27.5; p < 0.005). Postoperative satisfaction was not correlated with achieving a minimal clinically important difference, but it was correlated with magnitude of change in SNOT‐22 (r = 0.35; p < 0.05).ConclusionsNasal, smell, and sleep‐related symptoms were consdidered most important by this cohort. Meeting of preoperative expectations, improvement of the most important symptoms, and the magnitude of change in the SNOT‐22 may drive postoperative satisfaction.
Generation of Accelerating Beams along Arbitrary Trajectories
Authors: Qian Yixian , Zhang Site , Ren Zhijun 
Published: February 2019

AbstractA phase superposition approach for generating arbitrarily accelerating beams is proposed, where the superimposed phase is composed of multiple sub‐phases, each of which determines an independent sub‐beam or sub‐trajectory. Further, an effective algorithm is developed to improve the uniformity of the intensity along the arbitrary trajectory by introducing phase‐shift factors. Experimental results are consistent with numerical simulations. The proposed method can be extended to nonparaxial fields, and it also breaks the previous trajectory restrictions. The arbitrarily accelerating optical beams can pave the way for optically moving particles along a predefined trajectory. The property of such beams following arbitrary trajectories is likely to give rise to new applications in wave front control, flexible optical manipulation, and optical transport and guidance of particles.
Manganese(I)‐Catalyzed C−H Activation/Diels–Alder/retro‐Diels–Alder Domino Alkyne Annulation featuring Transformable Pyridines
Authors: Zhu Cuiju , Kuniyil Rositha , Ackermann Lutz 
Published: February 2019

AbstractComplexity‐increasing Domino reactions comprising C−H allenylation, a Diels–Alder reaction, and a retro‐Diels–Alder reaction were realized by a versatile catalyst derived from earth‐abundant, non‐toxic manganese. The C−H activation/Diels–Alder/retro‐Diels–Alder alkyne annulation sequence provided step‐economical access to valuable indolone alkaloid derivatives through a facile organometallic C−H activation manifold with transformable pyridines.
A Brønsted‐Ligand‐Based Iron Complex as a Molecular Switch with Five Accessible States
Authors: Shiga Takuya , Saiki Ryo , Akiyama Lisa , Kumai Reiji , Natke Dominik , Renz Franz , Cameron Jamie M. , Newton Graham N. , Oshio Hiroki 
Published: February 2019

AbstractA mononuclear FeII complex, prepared with a Brønsted diacid ligand, H2L (H2L=2‐[5‐phenyl‐1H‐pyrazole‐3‐yl] 6‐benzimidazole pyridine), shows switchable physical properties and was isolated in five different electronic states. The spin crossover (SCO) complex, [FeII(H2L)2](BF4)2 (1A), exhibits abrupt spin transition at T1/2=258 K, and treatment with base yields a deprotonated analogue [FeII(HL)2] (1B), which shows gradual SCO above 350 K. A range of FeIII analogues were also characterized. [FeIII(HL)(H2L)](BF4)Cl (1C) has an S=5/2 spin state, while the deprotonated complexes [FeIII(L)(HL)], (1D), and (TEA)[FeIII(L)2], (1E) exist in the low‐spin S=1/2 state. The electronic properties of the five complexes were fully characterized and we demonstrate in situ switching between multiple states in both solution and the solid‐state. The versatility of this simple mononuclear system illustrates how proton donor/acceptor ligands can vastly increase the range of accessible states in switchable molecular devices.
Visible‐light‐driven photocatalytic degradation using Mn‐doped SrMoO4 nanoparticles
Authors: Yao Zi‐Feng , Dai Zhen‐Xiang , Zhang Zhan‐Jun , Zheng Gan‐Hong , Xu Xin 
Published: February 2019

Mn‐doped SrMoO4 nanocrystals were synthesized by thermal decomposition of metal–organic salt in an organic solvent with the doping content in the range 0–12 mol%. The structures, morphologies and optical properties were characterized using various techniques. The results suggest that Mo sites in the SrMoO4 lattice are substituted by the Mn dopant, the adsorption bands are found to be shifted toward the visible light region and the band gap becomes narrower correspondingly. The photocatalytic performance of the as‐synthesized product was determined using the degradation of methylene blue by visible light irradiation. The photocatalytic performance is enhanced with Mn doping, and the optimal degradation rate is 85% in 140 min for 5 mol% Mn doping. The enhanced photocatalytic activity with Mn doping may be ascribed to the energy band adjustment and effective photogenerated electron–hole separation caused by the Mn doping. A possible photocatalytic mechanism is also discussed.
A novel microwave assisted reverse micelle fabrication route for Th (IV)‐MOFs as highly efficient adsorbent nanostructures with controllable structural properties to CO and CH4 adsorption: Design, and a systematic study
Authors: Sargazi Ghasem , Afzali Daryoush , Mostafavi Ali 
Published: February 2019

Reducing gas contaminants by affordable and effective adsorbents is a major challenge in the 21st century. In the present study, thorium metal organic framework (Th‐MOF) nanostructures are introduced as highly efficient adsorbents. These compounds were manufactured via a novel route resulting from the development of microwave assisted reverse micelle (MARM) and ultrasound assisted reverse micelle (UARM) methods. The products were characterized utilizing XRD, SEM, TGA/DSC, BET, and FT‐IR analyses. Based on the results, the samples synthesized by MARM had uniform size distribution, high thermal stability, and significant surface area. Calculations using DFT/B3LYP indicated that the compounds have a tendency to the polymeric form, which could theoretically confirm the formation of Th‐MOF. Results of analysis of variance (ANOVA) showed that synthesis parameters played a critical role in the manufacturing of products with distinctive properties. Response surface methodology (RSM) predicted the possibility of creating Th‐MOF adsorbents with the surface area of 2579 m2/g, which was a considerable value in comparison with the properties of other adsorbents. Adsorption studies showed that, in the optimum conditions, the Th‐MOF products had high adsorption capacity for CO and CH4. It is believed that the synthesis protocol developed in the present study and the systematic studies conducted on the samples which lead to products with ideal adsorption properties.
Hydrophilic Fe3O4 nanoparticles prepared by ferrocene as high‐efficiency heterogeneous Fenton catalyst for the degradation of methyl orange
Authors: Jia Xiangkun , Chen Xin , Liu Yin , Zhang Baoliang , Zhang Hepeng , Zhang Qiuyu 
Published: February 2019

Hydrophilic Fe3O4 nanoparticles were prepared with ferrocene as an iron source via the thermal decomposition method and their catalytic response towards methyl orange was investigated. The effects of the pH, temperature, H2O2 dosage, catalyst dosage and initial dye concentration on the degradation of methyl orange were researched in detail. Furthermore, the stability of the catalyst was evaluated by measuring the degradation rate in eight successive cycles. The study demonstrates that methyl orange can be completely degraded i.e., a 99% degratation rate was obtained within 3 min. This excellent catalytic activity is attributed to the small size and good dispersibility of the nanoparticles, which stimulate the rapid and massive generation of reactive oxygen species in the heterogeneous Fenton reaction. In addition, the magnetic separation of the catalyst offers great prospects for fast and economical decontamination of dye polluted water.
Bayesian semiparametric Markov switching stochastic volatility model
Authors: Virbickaitė Audronė , Lopes Hedibert F. 
Published: February 2019

AbstractThis paper proposes a novel Bayesian semiparametric stochastic volatility model with Markov switching regimes for modeling the dynamics of the financial returns. The distribution of the error term of the returns is modeled as an infinite mixture of Normals; meanwhile, the intercept of the volatility equation is allowed to switch between two regimes. The proposed model is estimated using a novel sequential Monte Carlo method called particle learning that is especially well suited for state‐space models. The model is tested on simulated data and, using real financial times series, compared to a model without the Markov switching regimes. The results show that including a Markov switching specification provides higher predictive power for the entire distribution, as well as in the tails of the distribution. Finally, the estimate of the persistence parameter decreases significantly, a finding consistent with previous empirical studies.
Large‐scale automated forecasting for network safety and security monitoring
Authors: Naveiro Roi , Rodríguez Simón , Ríos Insua David 
Published: February 2019

AbstractLarge‐scale real‐time streaming data pose major challenges to forecasting, in particular, defying the presence of human experts to perform the required analysis. We present here a class of models and methods used to develop an automated, scalable, and versatile system for large‐scale forecasting oriented toward network safety and security monitoring. Our system provides short‐ and long‐term forecasts and uses them to detect issues, well in advance, that might take place in relation with multiple Internet‐connected devices.
Copper nanoclusters: an efficient fluorescence sensing platform for quinoline yellow
Authors: Sivasankaran Unni , Radecki Jerzy , Radecka Hanna , Girish Kumar Krishnapillai 
Published: February 2019

AbstractFluorescence quenching behavior of artificial food colorant quinoline yellow (QY), on interaction with l‐cysteine stabilized copper nanoclusters (l‐Cys‐CuNCs) is investigated in this work. For this purpose, l‐cysteine stabilized CuNCs were synthesized and characterized using various analytical techniques. Results demonstrated that the synthesized probe (size ~2 nm) had very promising optical features such as bright blue fluorescence, significant quantum yield and excellent photostability. l‐Cys‐CuNCs can function as a fluorescence sensor by selectively sensing QY among other yellow colorants, giving a detection limit as low as 0.11 μM. The developed sensor exhibited a linear concentration range from 5.50 to 0.20 μM. The developed fluorescence assay was successfully applied for testing commercial samples, thereby making this sensing strategy significant for quality control of food stuffs.
TLD characteristic of glass, feldspathic and lithium disilicate ceramics
Authors: Isik Esme , Toktamis Huseyin 
Published: February 2019

AbstractThermoluminescence (TL) emission of dental ceramics could be potentially used for retrospective dosimetry purposes as this allows a quick and reliable dose assessment in case of nuclear accident or bad use of a nuclear attack. This paper reports on the chemical and luminescence characterization of glass, feldspathic and lithium disilicate glass ceramic (LS2). Swedish and Turkish dental ceramics supplied by Vivadent Ivoclar considering: (i) the dose response in the range 10 Gy to 6.9 kGy which displays a linear dose−response at low dose values up to 36 Gy (glass and feldspathic ceramics) and shows sublinear behavior from 12 Gy to 6 kGy (lithium disilicate glass ceramics), (ii) a reproducibility of the TL signal in which the area under the glow curve increased about 25% after 10 cycles for glass and lithium disilicate ceramics and increased about 30% after seven cycles for feldspathic ceramics, (iii) stability of the luminescence emission with the elapsed time and (iv) effect of the heating rate. Glass, lithium disilicate and feldspathic ceramics display a complex UV‐blue glow emission that can be respectively fitted to five and four groups of components assuming first‐order kinetics behavior.
Polymerization rate difference of N‐alkyl glycine NCAs: Steric hindrance or not?
Authors: Bai Tianwen , Ling Jun 
Published: February 2019

AbstractPolypeptoids synthesized from N‐substituted glycine N‐carboxyanhydrides (NNCAs) are widely applied in biological fields. The effect of side groups in NNCA polymerizations is a key to develop novel polypeptoids with complex topologies and constituents. In this work, density functional theory (DFT) calculations are employed to investigate the propagation of a series of alkyl substituted NNCAs with solvation model. According to both computational and experimental results, carbonyl addition is confirmed as rate determining step and steric hindrance is recognized as the major factor of low reactivity in β‐C branched NNCAs. However, in linear and γ‐C branched case, aggregation of side groups instead of bulkiness is considered responsible for low polymerization rate.
Virtual laboratory simulation in the education of laboratory technicians–motivation and study intensity
Authors: de Vries Lisbeth Elvira , May Michael 
Published: February 2019

AbstractThis study presents an evaluation of virtual laboratory simulation for educational use in the AP Degree Programme in Chemical and Biotechnical Science at University College Copenhagen in Denmark. The purpose was to test if, and how, virtual laboratory simulation could be applied to a practically oriented education such as the education of laboratory technicians—the aim being to motivate students and improve the education with new teaching tools. The study investigated how specific virtual lab simulation cases (Labster‐cases) may stimulate motivation, study intensity, and learning among laboratory technician students. Altogether, 78 students evaluated different educational aspects of using virtual lab cases in relation to a 2‐week course within gene technology. Overall, students were positive regarding the use of laboratory simulation as well as the specific cases tested. The study showed that virtual lab simulation seems to help laboratory technician students connect theory with practice and to visualize molecular processes as well as practical laboratory procedures and instrument techniques, however, it did also pose technical challenges. Furthermore, the study indicated that the use of virtual lab simulation cases can contribute to increased study activity as well as motivation. The overall conclusion of this study was that virtual lab simulation is an effective supplement to traditional teaching activities for the education of lab technicians. © 2019 International Union of Biochemistry and Molecular Biology, 47(3):257–262, 2019.
Peptides Containing meso‐Oxa‐Diaminopimelic Acid as Substrates for the Cell‐Shape‐Determining Proteases Csd6 and Pgp2
Authors: Soni Arvind S. , Lin Chang Sheng‐Huei , Murphy Michael E. P. , Tanner Martin E. 
Published: February 2019

AbstractThe enzymes Csd6 and Pgp2 are peptidoglycan (PG) proteases found in the pathogenic bacteria Helicobacter pylori and Campylobacter jejuni, respectively. These enzymes are involved in the trimming of non‐crosslinked PG sidechains and catalyze the cleavage of the bond between meso‐diaminopimelic acid (meso‐Dap) and d‐alanine, thus converting a PG tetrapeptide into a PG tripeptide. They are known to be cell‐shape‐determining enzymes, because deletion of the corresponding genes results in mutant strains that have lost the normal helical phenotype and instead possess a straight‐rod morphology. In this work, we report two approaches directed towards the synthesis of the tripeptide substrate Ac‐iso‐d‐Glu‐meso‐oxa‐Dap‐d‐Ala, which serves as a mimic of the terminus of an non‐crosslinked PG tetrapeptide substrate. The isosteric analogue meso‐oxa‐Dap was utilized in place of meso‐Dap to simplify the synthetic procedure. The more efficient synthesis involved ring opening of a peptide‐embedded aziridine by a serine‐based nucleophile. A branched tetrapeptide was also prepared as a mimic of the terminus of a crosslinked PG tetrapeptide. We used MS analysis to demonstrate that the tripeptide serves as a substrate for both Csd6 and Pgp2 and that the branched tetrapeptide serves as a substrate for Pgp2, albeit at a significantly slower rate.
Drug‐coated balloon versus uncoated percutaneous transluminal angioplasty for the treatment of atherosclerotic lesions in the superficial femoral and proximal popliteal artery: 2‐year results of the MDT‐2113 SFA Japan randomized trial
Authors: Iida Osamu , Soga Yoshimitsu , Urasawa Kazushi , Saito Shigeru , Jaff Michael R. , Wang Hong , Ookubo Hiroko , Yokoi Hiroyoshi ,   On behalf of the MDT‐2113 SFA Japan Investigators
Published: February 2019

AbstractObjectivesTo assess the longer‐term safety and efficacy of the IN.PACT Admiral (MDT‐2113) drug‐coated balloon (DCB) for the treatment of de novo and non‐stented restenotic lesions in the superficial femoral and/or proximal popliteal arteries versus uncoated percutaneous transluminal angioplasty (PTA) in a Japanese cohort.BackgroundAlthough DCBs are the newest endovascular strategy for patients with peripheral artery disease presenting with femoropopliteal lesions, there remains a paucity of results in non‐Caucasian populations.MethodsIN.PACT SFA Japan is an independently‐adjudicated, prospective, multicenter, randomized, single‐blinded trial. Endpoints through 2 years included primary patency and a composite safety endpoint of freedom from device‐ and procedure‐related death through 30 days, freedom from target limb major amputation and freedom from clinically‐driven target vessel revascularization at 24 months.ResultsOne hundred patients were assigned by 2:1 randomization to treatment with the IN.PACT Admiral DCB (n = 68) or PTA (n = 32). The groups were well‐matched at baseline. Mean lesion length for the DCB and PTA groups were 9.15 ± 5.85 and 8.89 ± 6.01 cm (P = 0.838), respectively. Patients treated with DCB exhibited superior 24‐month primary patency compared to PTA (79.8% vs. 46.9%; log rank P < 0.001). The 24‐month clinically driven target lesion revascularization rate was 9.1% for DCB versus 20.7% for PTA (P = 0.177). There were no device‐ or procedure‐related deaths, major amputations, or thromboses in either group.ConclusionsTwo‐year results from IN.PACT SFA Japan demonstrated persistently superior patency and low CD‐TLR rates through 2 years when compared to uncoated PTA in Japanese patients. These data are consistent with other IN.PACT DCB trials.
Ordered Mesoporous Co3O4−Al2O3Binary Metal Oxides for CO Hydrogenation to Hydrocarbons: Synergy Effects of Phosphorus Modifier for an Enhanced Catalytic Activity and Stability
Authors: Park Yong Min , Lee Dong Hyun , Lee Yun Jo , Roh Hyun‐Seog , Chung Chan‐Hwa , Wook Bae Jong 
Published: February 2019

AbstractThe synergy effects of phosphorus modifier on highly ordered mesoporous binary metal oxides of Co3O4−Al2O3(m‐CoAl), prepared by nanocasting method using a hard template of KIT‐6, were observed by an enhanced catalytic and structural stability of the m‐CoAl during CO hydrogenation to hydrocarbons. The enhanced structural stability of the ordered mesoporous structures on the phosphorous‐modified m‐CoAl at an optimal amount of phosphorous modifier below 0.3 wt%P (P(3)/m‐CoAl) was attributed to the partial formation of thermally stable metal phosphates under a reductive Fischer‐Tropsch synthesis (FTS) reaction condition. The positive effects of the phosphorous modifier were originated from the partially formed SiO2‐like AlPO4phases on the outer surfaces of the m‐CoAl, as well as from partially formed irreducible and thermally stable spinel‐type cobalt aluminates (CoAl2O4). The hydrophobic SiO2‐like tridymite AlPO4surfaces on the ordered matrices of the P/m‐CoAl also effectively prevented the heavy wax (or coke precursors) depositions. The structural instability of the P/m‐CoAl was observed at a higher phosphorous content above 0.5wt%P by preferentially forming the largely segregated mixed metal oxides such as Co3O4−CoAl2O4−Co3(PO4)2through the phase transformations of the surface excess AlPO4.
Quencher‐Delocalized Emission Strategy of AIEgen‐Based Metal–Organic Framework for Profiling of Subcellular Glutathione
Authors: Zhu Longyi , Wong Bernardino J. Córdova , Li Yang , Xin Hao , Liu Bin , Lei Jianping 
Published: February 2019

AbstractDistinguishing glutathione (GSH) level in different subcellular locations is critical for studying its antioxidant function in the signaling system. However, traditional methods for imaging subcellular GSH were achieved in isolated organelles or fixed cells. In this work, we report a quencher‐delocalized emission strategy for in situ profiling of GSH at different subcellular locations in living cells. A nonemissive metal–organic framework (MOF) nanoprobe was designed with AIEgen as the linker and CuII as the node and quencher. The AIEgen in MOF structure was lightened up with green emission in a neutral environment due to partial CuII delocalization by competitive binding to GSH. Meanwhile, along with the protonation of AIEgen ligand under acidic environment, the AIEgen‐based MOF could be completely dissociated in the presence of GSH to yield yellow emission. The two‐channel ratiometric analysis of dual‐colored emission of AIEgen‐based MOF allows visualization of GSH in cytoplasm and lysosome in living cells, which is also able to report the drug effects on different subcellular GSH levels.