bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging Therapeutic Targets in Oncologic Photodynamic Therapy
Authors: Manda Gina , Hinescu Mihail E. , Neagoe Ionela V. , Ferreira Luis F.V. , Boscencu Rica , Vasos Paul , Basaga Selma H. , Cuadrado Antonio 
Published: January 2019

Background:Reactive oxygen species sustain tumorigenesis and cancer progression through deregulated redox signalling which also sensitizes cancer cells to therapy. Photodynamic therapy (PDT) is a promising anti-cancer therapy based on a provoked singlet oxygen burst, exhibiting a better toxicological profile than chemo- and radiotherapy. Important gaps in the knowledge on underlining molecular mechanisms impede on its translation towards clinical applications.Aims and Methods:The main objective of this review is to critically analyse the knowledge lately gained on therapeutic targets related to redox and inflammatory networks underlining PDT and its outcome in terms of cell death and resistance to therapy. Emerging therapeutic targets and pharmaceutical tools will be documented based on the identified molecular background of PDT.Results:Cellular responses and molecular networks in cancer cells exposed to the PDT-triggered singlet oxygen burst and the associated stresses are analysed using a systems medicine approach, addressing both cell death and repair mechanisms. In the context of immunogenic cell death, therapeutic tools for boosting anti-tumor immunity will be outlined. Finally, the transcription factor NRF2, which is a major coordinator of cytoprotective responses, is presented as a promising pharmacologic target for developing co-therapies designed to increase PDT efficacy.Conclusion:There is an urgent need to perform in-depth molecular investigations in the field of PDT and to correlate them with clinical data through a systems medicine approach for highlighting the complex biological signature of PDT. This will definitely guide translation of PDT to clinic and the development of new therapeutic strategies aimed at improving PDT.
Evaluación interna y externa de la Revista Enfermería Universitaria de la eneo-unam durante el período 2004-2006.
Authors: Balseiro Almario Lasty , Torres Laguna María De los Ángeles , Zárate Grajales Rosa A. 
Published: January 2019

Objetivo: La finalidad de la presente investigación fue evaluar de forma interna y externa la revista Enfermería Universitaria de la ENEO-UNAM en el periodo comprendido del 2004-2006, a fin de identificar la calidad científica y editorial de la revista. Metodología: Las variables a identificar son las siguientes; de productividad, de estabilidad y obsolescencia, de calidad editorial, de calidad científica y de infraestructura. Tomando como base cada uno de estos indicadores se realizaron las preguntas de los cuestionarios. El tipo de investigación fue descriptivo, analítico, retrospectivo, longitudinal y de corte cuantitativo. El diseño fue no experimental. Los cuestionarios utilizados fueron de tres tipos: una guía de indicadores de los para los 9 ejemplares de la revista y dos cuestionarios para la evaluación externa, uno de ellos para las y los autores y el otro para las y los lectores. La aplicación de los cuestionarios fue para 50 autores y para 116 lectores. La investigación se realizó en el año 2007. Resultados: En la evaluación externa, el 90.5% de los autores fueron enfermeras en docencia e investigación y de los lectores, el 98% son enfermeras en administración, docencia e investigación. En cuanto a la calidad científica del 70-81% de las y los lectores y autoras/es refirió que la revista es un medio de comunicación primordial para enfermería que aporta información relevante. En relación con la calidad editorial entre el 75-85 % de las y los lectores y autoras/es indicó que los artículos son evaluados por pares, arbitrados localmente de manera anónima. En lo referente al diseño editorial, entre el 50 y el 99%, el diseño informativo es el adecuado pero requiere mejoras. La escala de grises y el tipo de letra es apropiada. Los espacios son suficientes. De la evaluación interna, se publicaron 9 ejemplares 80 artículos en siete secciones principalmente por profesorado y alumnado de la ENEO-UNAM y en una mínima proporción por autoras/ es de otras Universidades e Instituciones de salud del país y del extranjero. Se citaron 613 referencias: 210 de enfermería y 403 de otros profesionales de la salud, el número de citas promedio por artículo por ejemplar fue de 7 con un intervalo de 3.9 a 10.4. El idioma en que se cita fue predominantemente el español, el estilo de elaboración de citas es Vancouver. La revista a su corta edad es un vínculo de comunicación del pensamiento de enfermería en el país, fue publicada cuatrimestralmente y se constituyó en un recurso valioso para el desarrollo del conocimiento de la disciplina de Enfermería en México. Conclusiones: La evaluación realizada arrojó datos positivos. Sin embargo, la revista debe ser mejorada y fortalecida en todas sus debilidades para lograr la calidad científica y editorial.
Industria automotriz y TLCAN: Las empresas estadounidenses [1]
Authors: Castellanos Elías Julio 
Published: January 2019

<p>En la perspectiva de la industria automotriz el TLCAN fue el resultado de las estrategias que siguieron las ensambladoras de autos General Motor, Ford y Chrysler para tener acceso al mercado mexicano tanto como proveedor de mano de obra barata, abundante y calificada, como de un mercado para sus productos. También se conseguía el acceso a un país que les facilitó ventajas fiscales y laborales. En los 20 años del TLCAN las políticas en la industria han sido dictadas por estas armadoras. En el 2013 se ensamblaron en México más de 3 millones de vehículos, se emplean a más de 65 mil trabajadores en las plantas armadoras y 530 mil en la industria de autopartes. <strong></strong></p>
Minería global contemporánea o financiarizada
Authors: Concha Elizabeth 
Published: January 2019

<p align="right">Se analizan los mecanismos y agentes que luchan con avidez por los metales y minerales y la acumulación de capital en ese sector, el cual ha cambiado la minería del pasado por una a escala mundial. El creciente dominio de ese sector por el capital financiero ha venido intensificando la expansión de proyectos tendientes al control, extracción y exportación de recursos minerales, principalmente los metales preciosos. Se ha incrementado la explotación minera mundial en forma exponencial, acompañada de la concentración en la producción de minerales, a nivel país, productos y empresas.</p><p> </p><p> </p><p><strong> </strong></p><div><p> </p></div>
A Randomized Controlled Trial on the Safety and Efficacy of Exenatide Therapy for the Inpatient Management of General Medicine and Surgery Patients With Type 2 Diabetes
Authors: Fayfman Maya , Galindo Rodolfo J. , Rubin Daniel J. , Mize Dara L. , Anzola Isabel , Urrutia Maria A. , Ramos Clementina , Pasquel Francisco J. , Haw J. Sonya , Vellanki Priyathama , Wang Heqiong , Albury Bonnie S. , Weaver Rita , Cardona Saumeth , Umpierrez Guillermo E. 
Published: January 2019

OBJECTIVE
This multicenter, open-label, randomized trial examined the safety and efficacy of exenatide alone or in combination with basal insulin in non–critically ill patients with type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS
A total of 150 patients with blood glucose (BG) between 140 and 400 mg/dL, treated at home with diet, oral agents, or insulin at a total daily dose &lt;0.5 units/kg, were randomized to exenatide alone (5 μg twice daily), exenatide plus basal insulin, or a basal-bolus insulin regimen. The primary end point was difference in mean daily BG concentration among groups.

RESULTS
Mean daily BG was similar between patients treated with exenatide plus basal and a basal-bolus regimen (154 ± 39 vs. 166 ± 40 mg/dL, P = 0.31), and exenatide plus basal resulted in lower daily BG than did exenatide alone (177 ± 41 mg/dL, P = 0.02). Exenatide plus basal resulted in a higher proportion of BG levels in target range between 70 and 180 mg/dL compared with exenatide and basal-bolus (78% vs. 62% vs. 63%, respectively, P = 0.023). More patients in the exenatide and exenatide plus basal groups experienced nausea or vomiting than in the basal-bolus group (10% vs. 11% vs. 2%, P = 0.17), with three patients (6%) discontinued exenatide owing to adverse events. There were no differences in hypoglycemia &lt;54 mg/dL (2% vs. 0% vs. 4%, P = 0.77) or length of stay (5 vs. 4 vs. 4 days, P = 0.23) among basal plus exenatide, exenatide, and basal-bolus groups.

CONCLUSIONS
The results of this pilot study indicate that exenatide alone or in combination with basal insulin is safe and effective for the management of hospitalized general medical and surgical patients with T2D.
Desempeño agronómico y valor nutritivo de Tithonia diversifolia (Hemsl.) A Gray para la alimentación de bovinos
Authors: Londoño C Juan , Mahecha L. Liliana , Angulo A Joaquín 
Published: January 2019

La producción ganadera tradicional debido a la presión ejercida sobre los recursos, debe sufrir una transformación que incluya elementos que permitan la sostenibilidad de la actividad en el entorno productivo. La implementación de sistemas silvopastoriles se constituye en una alternativa viable para el mejoramiento de la producción a través de la inclusión de especies leñosas en el potrero para la formación de diferentes estratos, que generen múltiples beneficios a todos los elementos del ciclo bovino. La selección de las especies silvopastoriles debe ser realizada teniendo en cuenta aspectos agronómicos y composicionales para optimizar la respuesta animal. Este documento presenta una revisión sobre el potencial agronómico, la calidad nutricional y el uso del Botón de oro (Tithonia diversifolia – Asteraceae) en la alimentación de bovinos. Se describen las principales formas de establecimiento, contenido de nutrientes, producción de biomasa, acción en el suelo debido a su uso como abono verde y sus efectos productivos en la dieta de los rumiantes. El establecimiento del Botón de oro (Tithonia diversifolia), puede ser realizado a través de semilla sexual y vegetativa. Su composición nutricional muestra niveles elevados de proteína y carbohidratos solubles, bajo contenido de FDN, y niveles adecuados de minerales, su establecimiento y uso como abono verde puede mejorar las condiciones de fertilidad del suelo para aumentar la producción y rendimiento del pasto. Estas características le confieren una alto potencial en la alimentación bovina, ya sea como recurso para ramoneo, procesado en harina o ensilado, para reducir los costos de producción en explotaciones ganaderas.
From Struggle for Law to Struggle for Sovereignty
Authors: Klishas A. A. 
Published: January 2019

Introduction. The article deals with the problems of sovereignty of modern states in the context of political confrontation at the beginning of the 21st century. The author performs a legal analysis of the issue of a state’s constitutional identity limitation by supranational interstate associations and the issue of inter-ference of some states in the affairs of others as a modern trend of interstate communication.Materials and methods. The theoretical basis of the research is the views of the German jurisprudent R. Jhering on the correlation of objective law and subjective law, as well as on the conditions that are necessary for the existence of the rule of law. The empirical basis of the research is represented by the current legal regulation of the Russian Federation and the United States of America, as well as by legislative initiatives being under consideration in the Congress of the United States of America. The methodological basis of the research is the formal logical method, the method of system analysis, structural and functional method.Results. On the basis of the analysis of modern trends in the interstate in-teraction and after consideration of individual domestic political decisions taken in the Russian Federation and the United States of America the author con-cludes, that the international cooperation is impossible without adopting sover-eignty ensuring government measures which measure up both to the violation of the state’s constitutional identity by interstate associations and to the interference of states into the internal affairs of others.Discussion and conclusion. Interference of interstate associations in a state’s constitutional identity and states’ consistent interference in the internal af-fairs of other states are an absolutely unacceptable practice from the standpoint of international law. Such a practice prevents the construction of international cooperation on the basis of consensus and mutual respect and brings to naught the effectiveness of interstate cooperation.
Modality in Law: Cultural Contexts Differences
Authors: Glagolev V. S. 
Published: January 2019

Introduction.The article deals with the issue of cultural differences affecting positive law specifc character from the point of view of law and order awareness, as well as from the point of view of law enforcement. A classical sample is difference between Anglo-Saxon case law and written (prohibitive) law. The author scrutinizes modality types correlation, specially pointing out deontic and axiological modalities. Going back genetically to common semantic feld of sociocultural norm as a limit, rule of law can be viewed as a derivative from a broader context (“hidden modality”). This particular context presets possible interpretations limits, not always obvious for an outsider.Materials and methods.Methodological foundation for research is the comparison analysis method based on various interpretation types comparison and ascertainment of commensurability lacunas, important from the point of view of accuracy of a translation of language expressions with due consideration to their modality. Fixation on referential basis of these expressions, i.e. their principal focusing on reﬂection of real processes, as well as systems and consistence (“logicality”) principles peculiar to conception of positive law rational status, have a special importance in this case.Research results.The article shows that various modality types in law are connected on the one hand with linguo-cultural peculiarities, to which a specifc system of law is “tied”. On the other hand the law itself when forming its own conceptual construct enters the feld of forming a more strict and unifed (artifcial) language having reverse inﬂuence on “natural” views on rules of law. Such a language includes various modality types and exists in a complex interaction with perception of reality process and codifcation of corresponding social behavior rules, forming social space by means of such social regulator as positive law.Discussion and conclusion.The article describes basic logical conditions for making new rules of law and processing existing rules in the course of international treaties preparation. Possibilities and limitations of communicative practice inﬂuence on making rules of law have been analyzed, unobvious problems for an interpreter dealing with comparison of various sociocultural modality types specifc for national legal systems have been shown.
On the Draft Federal Law on Social and Cultural Adjustment and Integration of Foreign Citizens in the Russian Federation
Authors: Ivanchak A. I. 
Published: January 2019

Introduction.The process of adaptation and integration of foreign citizens in the host country is of high importance to ensure the balance of interests of community members. Representatives of various branches of knowledge (philosophy, sociology, psychology, law, pedagogy, etc.) are engaged in its study. Today social adaptation and integration of migrants are in the zone of special attention of the Russian state since steady development of our society is dependent on successful implementation of such policies. In this article the author analyses certain provisions of the draft Federal Law “On Social and Cultural Adaptation and Integration of Foreign Citizens in the Russian Federation and on Amendments to Certain Legislative Acts of the Russian Federation” prepared by the Federal Agency for Nationalities Affairs and submitted for public discussion.Materials and methods.The main research methods used hereinafter are theoretical analysis of the text of a regulatory act, analysis and synthesis of scientifc literature, methods of abstraction and induction, comparison and analogy as well as a formal logical method.The results of the study.An analysis of the content of the Draft Law made it possible to identify a number of provisions that seem to require adjustment. In particular, there is a need: - to clarify the defnition of the concepts of “social adaptation” and “social integration”; - to defne the concepts of “cultural adaptation” and “cultural integration” matching them with the concepts of “social adaptation” and social integration”; - to fnalise and systematise the list of measures set forth in the Draft Law as the conditions necessary for the success of the adaptation process and the integration of foreign citizens in the host country; - to adjust the terminology used by the legislator in relation to the activities carried out by the state. The author makes certain conclusions and provides due reasoning in the course of the analysis of the Draft Law provisions.Discussion and conclusion.Given the complexity of the process of adaptation and integration of migrants, its legal regulation is an extremely diffcult task for the legislator. At the same time such effor ts are vital as the lack of clarity of the legal norm, the ambiguity of the concepts used in the law often lead to a distorted interpretation and perception of the social phenomena.
Combating Corruption: the President of the Russian Federation Approved a New National Plan
Authors: Okhotsky E. V. 
Published: January 2019

Introduction. The article defnes the place and role of the institution of national anti-corruption planning in the context of the implementation of the state strategy to combat corruption practices, presents the main directions, principles, priorities and objectives of the new national anti-corruption plan, the main components of the mechanism of its implementation.Materials and methods. The scientifc and methodological basis of the this research is formed by the dialectical-materialistic concept of scientific analysis, a set of general scientifc and special methods of research of political, legal, social, moral and managerial aspects of the state strategy in the sphere of combating corruption.Results. The features of the content of the anticorruption powers of public authorities are presented; the nomenclature of innovative components of political, legal, economic, scientifc and educational initiatives of the state in the feld of combating corruption is presented; the main problems that should be paid attention to in the implementation of anticorruption measures under the national plan for the next three years are identifed. The issues of fighting elite corruption, de-offshorization of the economy, de-bureaucratization of management, optimization of the system of organization of tenders and auctions for procurement of goods and services for state and municipal needs, improving the effciency of legal, political and administrative mechanisms to combat corruption are also explored.Conclusion. The necessary generalizations and conclusions are made, some proposals are made to improve the existing anti-corruption mechanism in the Russian Federation.
External Relations of the Regions: the Main Problems of Paradiplomacy Theory
Authors: Loshkariov I. D. 
Published: January 2019

Introduction:The article discusses the theoretical basis of research in the feld of paradiplomacy or external relations of intrastate administrative-territorial entities. Paradiplomacy is an umbrella concept within several theoretical approaches that are significantly close in content. The author analyzes the main problems in the theory of diplomacy related to the lack of heuristic potential and the lack of a formed conceptual grid.Materials and methods:from a theoretical and methodological point of view, the author uses the hermeneutic approach, which allows to combine descriptive techniques and analysis of the subjective aspects of the given phenomenon. In addition, the author relies on a comparative historical method and a normative political analysis, which makes it possible to ft the facts of political reality into the framework of political theory. The paradiplomatic practice of Russia, Brazil, Canada, USA, Tanzania, and the Republic of South Africa acted as the material for the study.Research results:the author has identifed three main problems of the theory of paradiplomacy, which delay its further development. The theory of paradiplomacy does not have clear answers for questions of the spatial transformation of administrative-territorial units and the relationship of these transformation processes with paradiplomatic activity. The theory of paradiplomacy is unable to explain the phenomena of multilateral interregional relations and the unevenness of paradiplomatic activity.Discussions and conclusions:the author states that the existing theoretical approaches to paradiplomacy are mainly descriptive in nature and do not address the problems of a methodological, epistemological and normative nature, which is an undoubted drawback.
Хірургічне лікування місцево-розповсюджених та рецидивних солідних пухлин черевної порожнини та заочеревинного простору з нефректомією ex vivo ex situ та аутотрансплантацією нирки
Authors: Vasylyev O. V. , Sikachyov S. S. , Kvasivka O. O. , Kopetskyi V. I. , Cheverdyuk D. O. , Dorozhynskyi V. I. , Vitruk Yu. V. , Stakhovskyi O. E. , Kopchak K. V. 
Published: January 2019

Мета. Покращення результатів лікування хворих з місцево-розповсюдженими та рецидивними солідними пухлинами черевної порожнини та заочеревинного простору.
Матеріали і методи. За період з червня 2015 по січень 2018 р. в Національному інституті раку виконали комбіновані оперативні втручання з нефректомією 28 хворим з приводу первинних місцево-розповсюджених та рецидивних солідних пухлин черевної порожнини та заочеревинного простору.
Результати. У 5 із 28 пацієнтів виконали нефректомію ex vivo ex situ з аутотрансплантацією нирки, у 4 - успішно. Гостре ушкодження нирок спостерігали у 6 (26%) хворих, яким аутотрансплантації нирки не виконували. Після операції померли 2 (8,7%) хворих. У пацієнтів, яким нирка була збережена, не спостерігали гострого ушкодження нирок, ніхто з цих пацієнтів не помер.
Висновки. З метою профілактики розвитку гострого ушкодження та хронічної хвороби нирок у майбутньому можливість виконання аутотрансплантації нирки у разі хірургічного лікування солідних пухлин черевної порожнини та заочеревинного простору, окрім первинного раку нирки, повинна бути розглянута щодо кожного хворого. Дану процедуру доцільно виконувати в спеціалізованих лікувальних закладах, де накопичено досвід в онковаскулярній хірургії.
Studi Pemupukan Fosfat Terhadap Viabilitas Dan Vigor Benih Jagung (Zea mays L.) Varietas Hulaliu
Authors: Lesilolo M. K 
Published: January 2019

This study aimed to determine the best level of phosphate basic fertilization for seed production of Hulaliu corn varieties with high viability and vigor. This study was conducted in two places, namely in Booi Village, Saparua Subdistrict, Central Maluku District, for experiment with phosphate fertilization treatment, and in the Laboratory of Balai Besar Perbenihan dan Proteksi Tanaman Perkebunan Maluku in Passo, Baguala Subdistrict, Ambon, for testing seed viability and vigor. The experimental design used was a single factor Randomized Block Design with five levels of phosphate fertilization, consisting of P1 = 50 kg P2O5 per ha; P2 = 55 kg P2O5 per ha;. P3 = 60 kg P2O5 per ha; P4 = 65 kg P2O5 per ha, P5 = 70 kg P2O5 per ha = 70 kg, and with three replications. The results showed that the optimal levels of phosphate fertilization to enhance seed viability and vigor of Hulaliu local corn varieties were between 55 to 70 kg P2O5 per ha.