bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions of minimally invasive osteosynthesis: A 2018 survey of orthopedic surgeons
Authors: Robinson William P. , Knowles Toby G. , Barthelemy Nicolas P. , Parsons Kevin J. 
Published: August 2019

AbstractObjectiveTo report perspectives of minimally invasive osteosynthesis (MIO) techniques in veterinary surgical practice in 2018.Study designElectronic questionnaires.Sample populationDiplomates and residents of the American College of Veterinary Surgery and European College of Veterinary Surgery and members of the Veterinary Orthopedic Society.MethodsSurvey questions pertaining to MIO and minimally invasive plate osteosynthesis (MIPO) were sent electronically to the sample population. Questions assessed training, current caseload, benefits, and limitations of MIO and MIPO.ResultsTwo hundred fifty‐six veterinary surgeons completed questions pertaining to MIO, and 238 veterinary surgeons completed questions pertaining to MIPO. With regard to MIO, only 16% of respondents reported that they performed MIO regularly or exclusively, and 62% wanted to perform more MIO than they were currently undertaking. Tibial fractures were most commonly selected for MIO/MIPO stabilization techniques in both cats and dogs. Challenges in achieving adequate fracture reduction were identified as the greatest limitations of MIO/MIPO techniques. Forty‐three percent of respondents felt there were not enough MIPO training opportunities.ConclusionCurrently, MIO/MIPO techniques are performed infrequently, with a large proportion of respondents revealing that they would like to perform more in the future. There is also evidence that additional training opportunities would be welcomed for MIPO.Clinical significanceThe results of our survey provide evidence that, despite the benefits of MIO and MIPO compared with more traditional fracture stabilization approaches, significant barriers must be overcome before the techniques are likely to be more widely adopted.
A Machine Learning Approach to Customer Needs Analysis for Product Ecosystems
Authors: Zhou Feng , Ayoub Jackie , Xu Qianli , Jessie Yang X. 
Published: August 2019

AbstractCreating product ecosystems has been one of the strategic ways to enhance user experience and business advantages. Among many, customer needs analysis for product ecosystems is one of the most challenging tasks in creating a successful product ecosystem from both the perspectives of marketing research and product development. In this paper, we propose a machine-learning approach to customer needs analysis for product ecosystems by examining a large amount of online user-generated product reviews within a product ecosystem. First, we filtered out uninformative reviews from the informative reviews using a fastText technique. Then, we extract a variety of topics with regard to customer needs using a topic modeling technique named latent Dirichlet allocation. In addition, we applied a rule-based sentiment analysis method to predict not only the sentiment of the reviews but also their sentiment intensity values. Finally, we categorized customer needs related to different topics extracted using an analytic Kano model based on the dissatisfaction-satisfaction pair from the sentiment analysis. A case example of the Amazon product ecosystem was used to illustrate the potential and feasibility of the proposed method.
Decoupling of Multiple Concurrent Faults for Diagnosing Coal Cutter Gearboxes: An Extensive Experimental Investigation With Multichannel Sensor Measurements
Authors: Li Zhixiong , Liu Fushun , Sun Shuaishuai , Sarkodie-Gyan Th. , Li Weihua 
Published: August 2019

Abstract
Due to harsh operating environments in underground coal seams, the key components (e.g., gear pairs and bearings) in the power transmission systems of coal cutters suffer from extreme wear and functional damages. To guarantee the safe and reliable operation of the coal cutters, it is important to monitor the condition of their transmission systems and detect possible faults in a timely manner. A challenging task here is to diagnose multiple concurrent faults. A literature review indicates that the current interests lie on the decoupling of multiple co-existing faults and that the very limited work has been done to deal with the dependence/correlation between the fault signals. To address this issue, this work extends our previous work on gear crack detection using the bounded component analysis (BCA) and proposes an improved BCA-based approach for decoupling hybrid faults with high dependence/correlation in coal cutter transmission systems. The proposed approach incorporates the Vold–Kalman order tracking and spectral kurtosis into an improved BCA framework (OTBCA-SK). Owing to the uniform sampling of order tracking, the influence of background noise and rotational speed variation on vibration signals can be effectively reduced. Since BCA is capable of handling vibration sources that are statistically dependent, OTBCA-SK can decouple both independent and dependent source signals. As a result, the vibration sources excited by hybrid faults, although maybe dependent/correlated, can be fully decoupled into single-fault vibration source signals. Three specially designed case studies were used to evaluate the effectiveness of the proposed OTBCA-SK approach in decoupling hybrid gear faults. The analysis results demonstrate better performance of hybrid fault decoupling using OTBCA-SK than that of three representative techniques, i.e., Erdogan's BCA (E-BCA), joint approximate diagonalization of eigen matrices (JADE) and fast independent component analysis (FastICA). These case studies also suggest that the proposed OTBCA-SK approach can retain the physical meaning of the original vibration and is hence suitable for hybrid fault diagnosis in practical applications.
Surface Proteins on Gram-Positive Bacteria
Authors: Fischetti Vincent A. 
Published: August 2019

ABSTRACTSurface proteins are critical for the survival of gram-positive bacteria both in the environment and to establish an infection. Depending on the organism, their surface proteins are evolutionarily tailored to interact with specific ligands on their target surface, be it inanimate or animate. Most surface molecules on these organisms are covalently anchored to the peptidoglycan through an LPxTG motif found at the C-terminus. These surface molecules are generally modular with multiple binding or enzymatic domains designed for a specific survival function. For example, some molecules will bind serum proteins like fibronectin or fibrinogen in one domain and have a separate function in another domain. In addition, enzymes such as those responsible for the production of ATP may be generally found on some bacterial surfaces, but when or how they are used in the life of these bacteria is currently unknown. While surface proteins are required for pathogenicity but not viability, targeting the expression of these molecules on the bacterial surface would prevent infection but not death of the organism. Given that the number of different surface proteins could be in the range of two to three dozen, each with two or three separate functional domains (with hundreds to thousands of each protein on a given organism), exemplifies the complexity that exists on the bacterial surface. Because of their number, we could not adequately describe the characteristics of all surface proteins in this chapter. However, since the streptococcal M protein was one of the first gram-positive surface protein to be completely sequenced, and perhaps one of the best studied, we will use M protein as a model for surface proteins in general, pointing out differences with other surface molecules when necessary.
SecA-Mediated Protein Translocation through the SecYEG Channel
Authors: Komarudin Amalina Ghaisani , Driessen Arnold J. M. 
Published: August 2019

ABSTRACT
In bacteria, the Sec translocase mediates the translocation of proteins into and across the cytoplasmic membrane. It consists of a protein conducting channel SecYEG, the ATP-dependent motor SecA, and the accessory SecDF complex. Here we discuss the function and structure of the Sec translocase.
Shaping of intraplate mountain patterns: The Cantabrian orocline legacy in Alpine Iberia
Authors: Fernández-Lozano J. , Gutiérrez-Alonso G. , Willingshofer E. , Sokoutis D. , de Vicente G. , Cloetingh S. 
Published: August 2019

AbstractThe present-day topography in Iberia is related to geodynamic processes dealing with lithospheric-scale deformation. However, little attention has been paid to the role of inherited crustal- or lithospheric-scale structures involved in the recent observed large-scale topographic patterns. Whereas the analysis of brittle structures focuses on the evolution of Mesozoic sedimentary basins and their subsequent response to tectonic inversion, their contribution to mountain building has been underestimated. Large numbers of structures, from ductile to brittle, which affected the whole lithosphere, were developed during the evolution of the Cantabrian orocline (ca. 310–300 Ma). The contribution of these Paleozoic post-Variscan structures, together with lithospheric mantle evolution and replacement during orocline development in the Mesozoic and Cenozoic geological evolution of Iberia, remains unexplored. To explore the role of these inherited structures on the final configuration of topography during N-S Pyrenean shortening, we carried out a series of analogue experiments complemented by surface velocity field analyses. Our experiments indicate that strain was concentrated along preexisting crustal- to lithospheric-scale discontinuities, and they show several reactivation events marked by differences in the velocity vector field. Differences in fault displacement were also observed in the models depending upon preexisting fault trends. The obtained results may explain the different amount of displacement observed during the reactivation of some of the post-orocline structures in Iberia during the Cenozoic, indicating the key role of unveiled structures, which probably have accommodated most of the Alpine shortening.
Recent trends in energy and nutrient content of take-home food and beverage purchases in Great Britain: an analysis of 225 million food and beverage purchases over 6 years
Authors: Berger Nicolas , Cummins Steven , Smith Richard D , Cornelsen Laura 
Published: August 2019

IntroductionIn recent years, there has been an increased focus on developing a coherent obesity policy in the UK, which has led to various national policy initiatives aimed at improving population diet. We sought to determine whether there have been concurrent changes in trends in the nutrient content of take-home food and beverage purchases within this policy environment.MethodsWe used 2012–2017 data from the UK Kantar Fast-Moving Consumer Goods (FMCG) panel, a nationally representative panel study of food and beverages bought by British households and brought into the home (n≈32 000 per year). Households used hand-held barcode scanners to report over 225 million product-level purchases of food and beverages, for which nutritional information was obtained. We estimated daily per capita purchases of energy and nutrients from 32 healthier and less healthy food groups defined using the nutrient profiling model used by the UK Department of Health.ResultsFrom 2012 to 2017, daily purchases of energy from food and beverages taken home decreased by 35.4 kcal (95% CI 25.5 to 45.2) per capita. This is explained by moderate decreases in the purchase of products with high contents in carbohydrate (−13.1 g (−14.4 to –11.8)) and sugar (−4.4 g (−5.1 to –3.7)), despite small increases in protein (1.7 g (1.4 to 2.1)) and saturated fat (0.4 g (0.2 to 0.6)). Food and beverage purchases exceeded daily reference intake values in fat (on average +6%), saturated fat (+43%), sugar (+16%) and protein (+28%) across all years. Although substitutions between individual food groups were large in energy and nutrients purchased, the heterogeneity of these patterns resulted in modest overall changes.ConclusionThere have been small declines in the purchase of less healthy food products, which translated to a small reduction of total energy and sugar purchases taken home. However, the rate of change needs to be accelerated in order to substantially reduce the health risks of poor diets, suggesting that more radical policies may be needed to attain larger population effects.
Understanding the lived experiences of severe postnatal psychiatric illnesses in English speaking South Asian women, living in the UK: a qualitative study protocol
Authors: Sihre Harpreet Kaur , Gill Paramjit , Lindenmeyer Antje , McGuiness Mary , Berrisford Giles , Jankovic Jelena , Patel Minaxi , Lewin Jona , Fazil Qulsom 
Published: August 2019

IntroductionThe South Asian population is the UK’s largest and fastest growing minority ethnic group. There is evidence to suggest the lay understanding of postnatal psychiatric illnesses of this group may fall outside the purview of Western biomedical perspectives. Alternative explanations include psychosocial, cultural and spiritual factors. Approaching psychiatric illnesses through a social perspective includes gaining insight to the patient’s subjective experiences and understandings via qualitative inquiry. The objectives of this qualitative study are to explore South Asian women’s narrative of living with a severe postnatal psychiatric illness and experiences of Perinatal Mental Health Services, care and support.Methods and analysisData collection is ongoing and will continue until 31 December 2018. Participants will be identified and recruited from Perinatal Mental Health Services in Birmingham and London. Eligible participants will be English speaking South Asian females aged 18 years or above with the capacity to give written informed consent. Participants are clinically diagnosed with a severe postnatal psychiatric illness. This qualitative study uses individual in-depth face-to-face interviews that aim to last 1 hour. Interviews will be audio recorded with participants’ permission. Interview audio recordings will be transcribed verbatim and analysed using interpretative phenomenological analysis (IPA). The primary goal of IPA is for the researcher to closely study and interpret how individuals make sense of their life experiences in a particular context by drawing on the fundamental principles of phenomenology, hermeneutics and idiography.Ethics and disseminationThe University of Birmingham, the South Birmingham Research Ethics Committee and the Health Research Authority have approved this study (approvals date: 18-12-2017 ref: 17/WM/0350). Local capability and capacity have been confirmed from Trust Research and Development departments. The researchers plan to publish the results from this study in journals and present findings at academic conferences.
Subjective experiences of cognitive decline and receiving a diagnosis of dementia: qualitative interviews with people recently diagnosed in memory clinics in the UK
Authors: Xanthopoulou Penny , McCabe Rose 
Published: August 2019

ObjectivesTo explore people’s experiences of cognitive decline and receiving a diagnosis of dementia.Design61 semistructured interviews within 2 weeks of diagnosis. Audio recordings were transcribed, line-by-line coded using NVIVO V.11 and analysed using thematic analysis.Setting9 memory clinics (UK).ParticipantsPeople with mild/moderate dementia.ResultsMost participants were diagnosed with Alzheimer’s disease (56% female, mean age 81 years). 104 codes were grouped into 22 categories, feeding into 9 subthemes and 4 overarching themes: (1) dissonance, threat to identity and visibility of dementia: dementia was associated with a progressive loss of competence, culminating in being an idiot, crazy and losing the plot. The stigma of dementia led people to hide their diagnosis from others, even close family members. However, decreasing competence in everyday tasks was becoming increasingly visible in family and wider social networks. (2) Vulnerability and being in limbo: people were frustrated by the impact of dementia on their lives and felt vulnerable. Moreover, people were disturbed by not knowing how much and when they would deteriorate further. (3) Loss of control and agency: loneliness, increasing dependence and becoming a burden foreshadowed increasing diminished personal agency. (4) Maintaining agency and self-worth: some people focused on what they could do and the benefits of diagnosis. This involved accepting the diagnosis, adapting to changes by using coping strategies and accepting support from others. This helped people to maintain personal agency and self-worth.ConclusionWhile personal acceptance of dementia is challenging, people are additionally troubled about disclosing their diagnosis to others. Limited time in diagnostic appointments and limited postdiagnostic support leave few opportunities to address the emotional impact of a dementia diagnosis. There may be opportunities for healthcare professionals to discuss with patients the benefits of staying positive, implementing coping strategies and accepting support to live well with dementia.
Lost cost savings to the NHS in England due to the delayed entry of multiple generic low-dose transdermal buprenorphine: a case scenario analysis
Authors: Chapman Stephen Robert , Aladul Mohammed Ibrahim , Fitzpatrick Raymond William 
Published: August 2019

ObjectiveOriginator pharmaceutical companies prolonging the patent of a medicine prevents rivals’ entry to the market and competition. As the entry of generic alternatives usually results in price reduction, any delay in their entry potentially deprives the National Health Service (NHS) of much-needed savings. This study estimates the potential cost savings lost to the NHS as a result of delayed entry of generic low-dose buprenorphine (LDTB) patches in England.DesignTwo case scenarios were modelled to determine the savings from the entry of generic LDTB Butec only between February and August 2016 and the potential savings which could have been achieved if all generic LDTB patches had entered the market at the same time.SettingThe volume of utilisation of branded and generic LDTB in UK primary care was derived from the NHS business services authority website for prescriptions dispensed between February 2015 and January 2018.Main outcome measuresCost savings associated with the entry of generic LDTB.ResultsThe cumulative cost savings from the introduction of Butec alone was £0.7 ($0.92) million. The model predicted that if all generic buprenorphine entered the market at the same time with Butec, they could have been achieved a £1.2 ($1.57) million saving. This means that approximately £0.5 ($0.65) million savings was lost to the NHS over the 6-month time period.ConclusionsThe entry of Butec was associated with cost savings. We estimated that more cost savings could have been achieved if other generic LDTB patches had entered the market at the same time to drive competition between rivals. Patent protection strategies which delayed the entry of multiple generics were responsible for the reduced cost savings to the NHS in England.
Screening Of Pulmonary Hypertension in Methamphetamine Abusers (SOPHMA): rationale and design of a multicentre, cross-sectional study
Authors: Cheng Yangyang , Tung Chi-Kwong , Chung Albert Kar Kin , Liu Wan-Wan , Huang Duo , Chan Pak Hei , Lam Ming , Chan Wai-Chi , Siu Chung-Wah , Hai Jo Jo 
Published: August 2019

IntroductionMethamphetamine misuse is classified as a ‘likely’ risk factor for pulmonary arterial hypertension (PAH). Nevertheless, the actual prevalence of and a screening strategy for PAH in methamphetamine users have not been established. We plan to study the prevalence of PAH and identify its independent risk factors among methamphetamine users.Methods and analysisThe Screening Of Pulmonary Hypertension in Methamphetamine Abusers (SOPHMA) study will be a multicentre, cross-sectional screening study that will involve substance abuse clinics, hospitals and rehabilitation facilities in Hong Kong that cater to more than 20 methamphetamine users. A total of 400 patients who (1) are ≥18 years at enrolment; (2) report methamphetamine use in the last 2 years; (3) are diagnosed with methamphetamine use disorder; and (4) voluntarily agree to participate by providing written informed consent will be included. Patients will undergo standard echocardiography-based PAH screening procedures recommended for those with systemic sclerosis. Right heart catheterisation will be offered to participants with intermediate or high echocardiographic probability of PAH. For participants with a low echocardiographic probability of PAH, rescreening will be performed within 1 year. The primary measure will be the prevalence of PAH in methamphetamine users. The secondary measures will be the risk factors and a prediction model for PAH in methamphetamine users.Ethics and disseminationThe SOPHMA study has been approved by the institutional review board. The findings of this study will provide the necessary evidence to establish universal guidelines for screening of PAH in methamphetamine users. Our results will be disseminated through immediate feedback to study participants, press release to the general public, as well as presentation in medical conferences and publications in peer-reviewed journals to healthcare providers and academia worldwide.
Digital and online symptom checkers and health assessment/triage services for urgent health problems: systematic review
Authors: Chambers Duncan , Cantrell Anna J , Johnson Maxine , Preston Louise , Baxter Susan K , Booth Andrew , Turner Janette 
Published: August 2019

ObjectivesIn England, the NHS111 service provides assessment and triage by telephone for urgent health problems. A digital version of this service has recently been introduced. We aimed to systematically review the evidence on digital and online symptom checkers and similar services.DesignSystematic review.Data sourcesWe searched Medline, Embase, the Cochrane Library, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Health Management Information Consortium, Web of Science and ACM Digital Library up to April 2018, supplemented by phrase searches for known symptom checkers and citation searching of key studies.Eligibility criteriaStudies of any design that evaluated a digital or online symptom checker or health assessment service for people seeking advice about an urgent health problem.Data extraction and synthesisData extraction and quality assessment (using the Cochrane Collaboration version of QUADAS for diagnostic accuracy studies and the National Heart, Lung and Blood Institute tool for observational studies) were done by one reviewer with a sample checked for accuracy and consistency. We performed a narrative synthesis of the included studies structured around pre-defined research questions and key outcomes.ResultsWe included 29 publications (27 studies). Evidence on patient safety was weak. Diagnostic accuracy varied between different systems but was generally low. Algorithm-based triage tended to be more risk averse than that of health professionals. There was very limited evidence on patients’ compliance with online triage advice. Study participants generally expressed high levels of satisfaction, although in mainly uncontrolled studies. Younger and more highly educated people were more likely to use these services.ConclusionsThe English ‘digital 111’ service has been implemented against a background of uncertainty around the likely impact on important outcomes. The health system may need to respond to short-term changes and/or shifts in demand. The popularity of online and digital services with younger and more educated people has implications for health equity.PROSPERO registration numberCRD42018093564.