bluuebunny/crossref_metadata_2025_split huggingface dataset:
The 100 most-cited articles in the field of colorectal diseases from 1955 to 2018: A bibliometric analysis
Authors: LuoLuo Mengqi , Zhang Chunmei , Ren Yutang , Peng Wei , Zhong Chunyu , Peng Yan , Tang Xiaowei 
Published: March 2019

Abstract

Background: The number of times that an article was cited reflected its impact. In this study, we aimed to recognize and analyze the characteristics of the most frequently cited articles in the field of colorectal diseases.
Methods: We identified the 100 highest cited articles using the terms ‘colorectal’ or ‘colon’ or ‘rectal’ or ‘IBD’ or ‘ulcerative colitis’ or ‘Crohn disease’ or ‘colonoscopy’ in Web of Science. Articles were analyzed to evaluate the characteristics including number of citations, country of origin, institutions of origin based on the first author affiliation, study type and others.
Results: Of the top cited publications, the number of citations ranged from 1479 to 8834 with a mean of 2304.85 citations per article. The journal with the greatest number of most-cited articles was New England Journal of Medicine (n=23), followed by Science (n=13) and Nature (n=12). These papers were published in 14 different countries, of which more than half were from the United States (n=64). The most popular field was colorectal cancer (n=51), followed by colonic tumor (n=21). Most of the papers were basic science studies (n=44) and randomized controlled trials (n=29).
Conclusion: Our study could provide a historical perspective on the scientific progress in the field of colorectal diseases, which would lay a firm foundation for future research.
Evaluation of Potassium Bromate in Bread in Ibadan Metropolis: Fifteen Years after Ban in Nigeria
Authors: Airaodion Augustine I. , Ewa Ogbonnaya , Ogbuagu Emmanuel O. , Ogbuagu Uloaku , Agunbiade Aanu P. , Oloruntoba Abiodun P. 
Published: March 2019

Background: In 2003, the National Agency for Food, Drug Administration and Control (NAFDAC), the agency responsible for regulating drugs, foods and chemicals in Nigeria, banned the use of potassium bromate in bread on account of its deleterious effect and carcinogenicity in humans.
Aim: This study is aimed at investigating the level of compliance to the use of potassium bromate in bread fifteen years after ban.
Study Design: This study was made to fit a one way Analysis of Variance.
Place and Duration of Study: This research was carried out in Ibadan, the Oyo State capital of Nigeria between July and December, 2018.
Methodology: Thirty loaves of bread were purchased in Ibadan metropolis. They were analyzed qualitatively and quantitatively for the presence of potassium bromate in them. Quantitative determination was done using spectrophotometric method that is based on the redox reaction between bromate and promethazine hydrochloride in an acidic medium. The absorbance of the product was read at 620 nm. The qualitative test was performed directly on a portion of each bread sample using 2 ml of 0.01 M promethazine and 0.6 ml of 12 M hydrochloric acid. The change in colour of each bread sample to purple indicates the presence of potassium bromate.
Results: All the 30 bread samples analyzed contain potassium bromate. The concentration of KBrO3 in the sampled bread ranged between 1.24 µg/g and 9.31 µg/g. The quantity of KBrO3 in each bread sample correlates with the degree of purple colour obtained in the qualitative test.
Conclusion: Since all the sampled bread had potassium bromate in concentration above safe level for human consumption, bread consumers and bakers are at risk of exposure to potassium bromate with health implications. The need for continuous surveillance and enforcement of the ban on use of potassium bromate in baking industry in Nigeria is recommended.
Development and Gas Exchange of Pre-sprouted Sugarcane Seedlings in Three Different Growing Substrate Media
Authors: De Jesus Hanna Ibiapina , Medeiros Maria Luiza De Souza , Queiroz Lopes Maria De Fátima de , Souza Oliveira Bruno De , Da Silva Galileu Medeiros , Mielezrski Fábio 
Published: March 2019

Objective: Evaluate the development and gas exchange of pre-sprouted sugarcane seedlings in different substrates.
Study Design: A randomized complete block design was used with two genotypes, three types of substrate (2 x 3), four replicates and five plants per replicate, totaling 120 plants.
Location and Duration of Study: Department of Crop Sciences of the Center for Agrarian Sciences, Universidade Federal de Paraíba in the city of Areia, Brazil, between August and October 2018.
Methods: The following were the treatments: T1 – genotype 1 in commercial substrate; T2 – genotype 1 in commercial substrate + bovine manure; T3 – genotype 1 in bovine manure + sand; T4 – genotype 2 in commercial substrate; T5 – genotype 2 in commercial substrate + bovine manure; T6 – genotype 2 in bovine manure + sand. Variables analyzed: height, diameter, dry mass of shoot and root and physiological response of seedlings.
Results: A significant difference at the 1% level was found for the dry matter of the seedling roots among treatments with difference substrates. A significant difference at the 1% level was also found for shoot length and a significant interaction at the 5% level was found between genotype and substrate for this characteristic. Significant effects were found with regard to the rate of photosynthesis, stomatal conductance, transpiration and carboxylation efficiency.
Conclusion: The substrate with manure + sand favored the accumulation of root dry matter and shoot length. Genotype 1 exhibited its best performance with regard to photosynthesis and stomatal conduction in the treatment with the commercial substrate and demonstrated greater carboxylation efficiency than genotype 2, independently of the substrates. The pre-sprouted seedling production system needs to be explored further to obtain greater information regarding the nutritional requirements and characteristics of the genotypes.
Does adolescent heavier alcohol use predict young adult aggression and delinquency? Parallel analyses from four Australasian cohort studies
Authors: Najman Jake M. , Plotnikova Maria , Horwood John , Silins Edmund , Fergusson David , Patton George C , Olsson Craig , Hutchinson Delyse M , Degenhardt Louisa , Tait Robert , Youssef George J. , Borschmann Rohan , Coffey Carolyn , Toumbourou John W , Mattick Richard P. 
Published: March 2019

AbstractWhile the association between heavy alcohol consumption and aggression has been well documented, the causal direction of this association, particularly at a population level, is disputed. A number of causal sequences have been proposed. First, that aggression leads to heavy alcohol use. Second, that heavy alcohol use leads to aggression. Third, that the association between alcohol use and aggression is due to confounding by (a) sociodemographic variables or (b) delinquency. We report here data from four Australasian prospective longitudinal studies of adolescents, to assess the temporal sequence of heavy drinking and aggression over the period from adolescence to young adulthood. The four cohort studies provide a total sample of 6,706 persons (Australian Temperament Project, n = 1701; Christchurch Health and Development Study, n = 931; Mater‐University of Queensland Study of Pregnancy, n = 2437; Victorian Adolescent Health Cohort Study, n = 1637). We use multinomial logistic regression to determine whether early adolescent aggression predicts subsequent age of onset of heavy episodic drinking (HED), after adjustment for concurrent sociodemographic factors and delinquency. We then consider whether HED predicts subsequent aggression, after adjusting for past aggression, concurrent delinquency, and a range of confounders. There are broadly consistent findings across the four cohort studies. Early aggression strongly predicts subsequent HED. HED predicts later aggression after adjustment for prior aggression and other confounders. Policies that alter population levels of alcohol consumption are likely to impact on levels of aggression in societies where HED linked to aggression is more common.
An examination of the potential lingering effects of smartphone use on cognition
Authors: Frost Peter , Donahue Patrick , Goeben Keith , Connor Megan , Cheong Hoong Sing , Schroeder Aaron 
Published: March 2019

SummarySmartphones might offer an extension of our own cognitive abilities, potentially preventing practice of certain forms of cognition. Our first study established that heavier usage of smartphones was negatively correlated with social problem solving and delayed gratification, as well as positively correlated with some aspects of critical thinking. Studies 2 and 3 involved experiments where participants were assigned to either a lower or higher smartphone usage group. In both experiments, higher usage of smartphones led only to a diminished ability to interpret and analyze the deeper meaning of information. However, Study 3 showed that, after a 4‐week interval, the difference in the ability to interpret and analyze meaning between lower and higher phone usage groups was no longer evident. The findings of this study suggest that, even in the rare cases where smartphones might alter cognition, this effect is likely transitory.
Scalable High‐Throughput Production of Modular Microgels for In Situ Assembly of Microporous Tissue Scaffolds
Authors: de Rutte Joseph Michael , Koh Jaekyung , Di Carlo Dino 
Published: March 2019

AbstractHydrogel scaffolds that template the regeneration of tissue structures are widely explored; however, there is often a trade‐off between material properties, such as stiffness and interconnected pore size, that may be equally important in supporting tissue growth. Microporous annealed particle scaffolds are introduced to address this trade‐off while maintaining a flowable precursor; however, manufacturing throughput, reproducibility, and flexibility of hydrogel microparticle building blocks are limited, hindering widespread adoption. The scalable high‐throughput production of bioactive microgels for the formation of microporous tissue scaffolds in situ is presented. Using a parallelized step emulsification device, scalable high‐throughput generation of monodisperse microgels is achieved. Crosslinking is initiated downstream of droplet generation using pH modulation via proton acceptors dissolved in the oil phase. This approach enables continuous production of microgels for over 12 h while ensuring highly uniform physicochemical properties. Using this platform, the effects of local matrix stiffness on cell growth orthogonal to scaffold porosity are studied. Formation of injectable cell‐laden mechanically heterogeneous microporous scaffolds is also demonstrated. This approach is particularly suited for the formation of modular, multimaterial scaffolds in situ, which could be applied to 3D bioprinting or to form more complex scaffolds to enhance regeneration of irregular wounds.
Identification of Phase Control of Carbon‐Confined Nb2O5 Nanoparticles toward High‐Performance Lithium Storage
Authors: Meng Jiashen , He Qiu , Xu Linhan , Zhang Xingcai , Liu Fang , Wang Xuanpeng , Li Qi , Xu Xiaoming , Zhang Guobin , Niu Chaojiang , Xiao Zhitong , Liu Ziang , Zhu Zizhong , Zhao Yan , Mai Liqiang 
Published: March 2019

AbstractNiobium pentoxides (Nb2O5) have attracted extensive interest for ultrafast lithium‐ion batteries due to their impressive rate/capacity performance and high safety as intercalation anodes. However, the intrinsic insulating properties and unrevealed mechanisms of complex phases limit their further applications. Here, a facile and efficient method is developed to construct three typical carbon‐confined Nb2O5 (TT‐Nb2O5@C, T‐Nb2O5@C, and H‐Nb2O5@C) nanoparticles via a mismatched coordination reaction during the solvothermal process and subsequent controlled heat treatment, and different phase effects are investigated on their lithium storage properties on the basis of both experimental and computational approaches. The thin carbon coating and nanoscale size can endow Nb2O5 with a high surface area, high conductivity, and short diffusion length. As a proof‐of‐concept application, when employed as LIB anode materials, the resulting T‐Nb2O5@C nanoparticles display higher rate capability and better cycling stability as compared with TT‐Nb2O5@C and H‐Nb2O5@C nanoparticles. Furthermore, a synergistic effect is investigated and demonstrated between fast diffusion pathways and stable hosts in T‐Nb2O5 for ultrafast and stable lithium storage, based on crystal structure analysis, in situ X‐ray diffraction analysis, and density functional theoretical calculations. Therefore, the proposed synthetic strategy and obtained deep insights will stimulate the development of Nb2O5 for ultrafast and long‐life LIBs.
High‐Performance Ultrathin Co3O4 Nanosheet Supported PdO/CeO2 Catalysts for Methane Combustion
Authors: Li Wang , Liu Dapeng , Feng Xilan , Zhang Zheng , Jin Xin , Zhang Yu 
Published: March 2019

AbstractEfficient utilization of methane via catalytic complete combustion is a very important pathway to realize energy efficiency and pollution reduction. From the viewpoint of structural design, herein a green water‐phase route is developed to prepare ultrathin Co(OH)2 nanosheet supported Pd catalysts. As a platform, the as‐obtained Pd/Co(OH)2 nanosheets are able to be further used to load CeO2 nanoparticles to form 2D nanostructured Pd/CeO2/Co(OH)2 multicomponent hybrids, and further calcination can result in the final well‐crystallized ultrathin Co3O4 nanosheet supported PdO/CeO2 catalysts. Catalytic tests on methane combustion reveal that CeO2 as a catalytic assistant greatly boosts the catalytic performance of PdO/Co3O4 via strong synergetic effects with Pd species and Co3O4 components. The best sample of PdO/CeO2‐0.1/Co3O4 exhibits surprisingly enhanced light‐off activity, indicating that such 2D Co3O4 nanosheet supported nanocatalysts might show promising prospect for heterogeneous catalysis.
A Pair of NiCo2O4 and V2O5 Nanowires Directly Grown on Carbon Fabric for Highly Bendable Lithium‐Ion Batteries
Authors: Son Ji‐Myeong , Oh Saewoong , Bae Seok‐Hu , Nam Sanghee , Oh Il‐Kwon 
Published: March 2019

AbstractMechanically bendable and flexible functionalities are urgently required for next‐generation battery systems that will be included in soft and wearable electronics, active sportswear, and origami‐based deployable space structures. However, it is very difficult to synthesize anode and cathode electrodes that have high energy density and structural reliability under large bending deformation. Here, vanadium oxide (V2O5) and nickel cobalt oxide (NiCo2O4) nanowire‐carbon fabric electrodes for highly flexible and bendable lithium ion batteries are reported. The vanadium oxide and nickel cobalt oxide nanowires were directly grown on plasma‐treated carbon fabric and were used as cathode and anode electrodes in a full cell lithium ion battery. Most importantly, a pre‐lithiation process was added to the nickel cobalt oxide nanowire anode to facilitate the construction of a full cell using symmetrically‐architectured nanowire‐carbon fabric electrodes. The highly bendable full cell based on poly(ethylene oxide) polymer electrolyte and room temperature ionic liquid shows high energy density of 364.2 Wh kg−1 at power density of 240 W kg−1, without significant performance degradation even under large bending deformations. These results show that vanadium oxide and lithiated nickel cobalt oxide nanowire‐carbon fabrics are a good combination for binder‐free electrodes in highly flexible lithium‐ion batteries.
Enantioselective Total Synthesis of (+)‐Flavisiamine F via Late‐Stage Visible‐Light‐Induced Photochemical Cyclization
Authors: Tong Xiaogang , Shi Bingfei , Liang Kangjiang , Liu Qian , Xia Chengfeng 
Published: March 2019

AbstractThe structural features Kopsia alkaloids, in particular multiple all‐carbon quaternary stereocenters in a caged and strained polycyclic skeleton, poses particular challenges for enantioselective total synthesis. Herein, we reported the first total synthesis of (+)‐flavisiamine F. The synthetic approach involved a room‐temperature Overman rearrangement for introducing the chiral amine at C21, a TMS‐promoted ketal Claisen rearrangement for constructing the all‐carbon quaternary stereocenter at C20, and a late‐stage visible‐light‐induced photochemical cyclization for establishing the all‐carbon quaternary stereocenter at C7.
Designed Synthesis of a 2D Porphyrin‐Based sp2Carbon‐Conjugated Covalent Organic Framework for Heterogeneous Photocatalysis
Authors: Chen Rufan , Shi Ji‐Long , Ma Yuan , Lin Guiqing , Lang Xianjun , Wang Cheng 
Published: March 2019

AbstractThe construction of stable covalent organic frameworks (COFs) for various applications is highly desirable. Herein, we report the synthesis of a novel two‐dimensional (2D) porphyrin‐based sp2carbon‐conjugated COF (Por‐sp2c‐COF), which adopts an eclipsed AA stacking structure with a Brunauer—Emmett—Teller surface area of 689 m2 g−1. Owing to the C=C linkages, Por‐sp2c‐COF shows a high chemical stability under various conditions, even under harsh conditions such as 9 mHCl and 9 mNaOH solutions. Interestingly, Por‐sp2c‐COF can be used as a metal‐free heterogeneous photocatalyst for the visible‐light‐induced aerobic oxidation of amines to imines. More importantly, in comparison to imine‐linked Por‐COF, the inherent structure of Por‐sp2c‐COF equips it with several advantages as a photocatalyst, including reusability and high photocatalytic performance. This clearly demonstrates that sp2carbon‐linked 2D COFs can provide an interesting platform for heterogeneous photocatalysis.
Enhanced chemiluminescence enzyme‐linked immunoassay for the determination of DNA methyltransferase 1 in human serum
Authors: Dong Jiajia , He Leiliang , Yu Fei , Yu Songcheng , Liu Lie , Tian Yongmei , Wang Yilin , Wang Jia , Qu Lingbo , Wu Yongjun , Han Runping 
Published: March 2019

AbstractThe occurrence of many diseases is closely related to the high expression of DNA methyltransferase 1 (DNMT1). However, most studies are focused on the detection of DNMT1 activity, a few are concerned with the detection of DNMT1 content. In this study, we developed a simple and highly sensitive chemiluminescence (CL) assay for the detection of DNMT1 content. In this method, anti‐DNMT1 monoclonal antibody was coated on a polystyrene microplate to capture DNMT1. Then anti‐DNMT1 polyclonal antibody and goat anti‐rabbit immunoglobulin G with horseradish peroxidase (IgG‐HRP) were respectively added to combine with captured DNMT1 to form a sandwich structure. Finally, the HRP could catalyze CL substrate and achieve CL signal response. Based on this novel sensitive strategy, the recovery percents were in the ranges from 71.5% to 91.0%. The precision of intra‐assays and inter‐assays were 5.45%–11.29% and 7.03%–11.25%, respectively. The method was successfully applied for the determination of DNMT1 in human serum. The detection results of serum samples showed that the proposed assay had a high correlation with enzyme‐linked immunosorbent assay (ELISA) kit. Compared with the ELISA kit (limit of detection = 0.1 ng/mL), the method has a lower limit of detection of 0.042 ng/mL. Therefore, our method has the potential for the detection of DNMT1 content in clinical diagnosis.
Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference
Authors: Xiong Kai , Marquart Kim Fabiano , la Cour Karottki Karen Julie  , Li Shangzhong , Shamie Isaac , Lee Jae Seong , Gerling Signe , Yeo Nan Cher , Chavez Alejandro , Lee Gyun Min , Lewis Nathan E. , Kildegaard Helene Faustrup 
Published: March 2019

AbstractChinese hamster ovary (CHO) cells are widely used for biopharmaceutical protein production. One challenge limiting CHO cell productivity is apoptosis stemming from cellular stress during protein production. Here we applied CRISPR interference (CRISPRi) to downregulate the endogenous expression of apoptotic genes Bak,
Bax, and
Casp3 in CHO cells. In addition to reduced apoptosis, mitochondrial membrane integrity was improved and the caspase activity was reduced. Moreover, we optimized the CRISPRi system to enhance the gene repression efficiency in CHO cells by testing different repressor fusion types. An improved Cas9 repressor has been identified by applying C‐terminal fusion of a bipartite repressor domain, KRAB–MeCP2, to nuclease‐deficient Cas9. These results collectively demonstrate that CHO cells can be rescued from cell apoptosis by targeted gene repression using the CRISPRi system.
The impact of structural factors on diagnostic delay in diffuse large B‐cell lymphoma
Authors: Zurko Joanna C. , Wade Raymond C. , Mehta Amitkumar 
Published: March 2019

AbstractBackgroundReducing diagnostic delays in cancer has been a major interest worldwide; however, the literature on diagnostic delays in lymphoma remains scarce. Diffuse large B‐cell lymphoma (DLBCL) is the most common non‐Hodgkin's lymphoma. We aimed to determine whether certain structural factors predicted diagnostic delays in DLBCL and whether diagnostic delays impacted overall survival (OS).MethodsData were extracted via a retrospective cohort design from a single academic tertiary care referral center. A total of 104 patients were included. Time from first symptoms to diagnosis of <3 months was defined as “early diagnosis” and ≥3 months as “delayed diagnosis”. Analysis was performed with student's t‐test, chi‐square testing, binomial logistic regression, and Kaplan‐Meier log‐rank testing.Results“Delayed diagnosis” was more likely with lower stage, lower international prognostic index (IPI), and further distance from referral center (OR 0.66, CI 0.46‐0.95; OR 0.69, CI 0.51‐0.94; OR 1.008, CI 1.001‐1.015). Patients of “other” ethnicity and without medical insurance were more likely to have significant diagnostic delays and worse overall survival (P = 0.002 and P = 0.007, respectively). Diagnostic delays of ≥3 months did not predict worse OS. However, delays of >6 months did predict worse OS.ConclusionOur data suggest that excessive diagnostic delays of more than 6 months, ethnic minority status, and uninsured status in DLBCL may lead to worse outcomes. Efforts should be undertaken to reduce excessive diagnostic delays. More investigation needs to be done on the impacts of diagnostic delays in both DLBCL and other aggressive lymphomas.