bluuebunny/crossref_metadata_2025_split huggingface dataset:
O TRABALHO DIDÁTICO NAS SOCIEDADES MESOPOTÂMICAS EL TRABAJO DIDÁTICO EN LAS SOCIEDADES MESOPOTÁMICAS THE DIDACTIC WORK IN MESOPOTAMIC SOCIETY
Authors: Martins Jander Fernandes , Wingert Vitória Duarte 
Published: October 2018

<p>O presente trabalho é fruto de um estudo realizado pelos autores em disciplina vinculada ao PPG Processos e Manifestações Culturais-FEEVALE, objetivando “identificar e analisar as formas históricas de educadores na civilização mesopotâmica”. Para isso, valeu-se de uma pesquisa bibliográfica em manuais da História da Educação. O referencial teórico-metodológico pautou-se na categoria analítica O<em>rganização do Trabalho Didático, Formações socioculturais </em>e <em>Processo Civilizatório</em>. Por fim esse estudo demonstrou ser o <em>escriba</em>, a primeira forma histórica de <em>preceptorado</em>. Constituindo seu trabalho didático, a partir de um instrumental didático e em um <em>local específico</em>, os <em>zigurats</em>. A pertinência desse estudo se revelou profícuo, pois os estudos sobre as civilizações Antigas, na perspectiva marxista/marxiana, apresentam instigantes reflexões, abrindo um leque de discussão merecedor de atenção.</p>
FORMAÇÃO DO PROFESSOR NO CONTEXTO DAS NOVAS DIRETRIZES CURRICULARES NACIONAIS
Authors: Santos Adriana Regina de Jesus , Gonçalves Jose Alexandre , Silva Thaise Pereira da , Costa Rogerio Da 
Published: October 2018

<p>Analisam-se neste trabalho algumas questões referentes à construção da identidade profissional do professor, implícita nas atuais Diretrizes Curriculares Nacionais para a Formação Inicial e Continuada dos Profissionais do Magistério da Educação Básica. Para a realização deste estudo utilizamos como metodologia a pesquisa bibliográfica e documental, cuja finalidade foi apresentar como estas diretrizes orientam a formação dos licenciados para a atuação docente, tendo em vista as propostas que se estabelecem nos princípios e fundamentos dessa resolução. Acreditamos que essa discussão possibilitará a reflexão sobre a relevância dessa normativa, oportunizando transformações no âmbito da formação inicial de professores.</p><p> </p><p> Formação de professores; Licenciatura, Diretrizes.</p>
A EDUCAÇÃO FÍSICA E SUAS POSSIBILIDADES NO ENSINO MÉDIO INTEGRADO
Authors: Marques Guilherme De Souza , Gawryszewski Bruno 
Published: October 2018

O presente texto tem como objetivo analisar o papel da Educação Física em instituições que ofereçam a modalidade de Ensino Médio Integrado. Trata-se de uma pesquisa teórico-empírica em que foi combinada a revisão bibliográfica sobre o Ensino Médio Integrado e a Educação Física com observações e entrevistas como instrumentos da pesquisa de campo. O estudo defende que a Pedagogia Crítico-Superadora para o ensino da Educação Física se constitui no fundamento teórico-pedagógico mais adequado para a perspectiva da integração do Ensino Médio com a Educação Profissional. Concluímos com a pesquisa de campo que há um esforço em organizar a disciplina de forma mais integrada, embora ainda falte maior organicidade e clareza da proposta.
Clinical commissioning of a new patient positioning system, SyncTraX FX4, for intracranial stereotactic radiotherapy
Authors: Tanabe Satoshi , Umetsu Osamu , Sasage Toshikazu , Utsunomiya Satoru , Kuwabara Ryota , Kuribayashi Toshiki , Takatou Hiromasa , Kawaguchi Gen , Aoyama Hidefumi 
Published: October 2018

AbstractBackground & AimsA new real‐time tracking radiotherapy (RTRT) system, the SyncTraX FX4 (Shimadzu, Kyoto, Japan), consisting of four X‐ray tubes and four ceiling‐mounted flat panel detectors (FPDs) combined with a linear accelerator, was installed at Uonuma Kikan Hospital (Niigata, Japan) for the first time worldwide. In addition to RTRT, the SyncTraX FX4 system enables bony structure‐based patient verification. Here we provide the first report of this system's clinical commissioning for intracranial stereotactic radiotherapy (SRT).Materials & MethodsA total of five tests were performed for the commissioning: evaluations of (1) the system's image quality; (2) the imaging and treatment coordinate coincidence; and (3) the localization accuracy of cone‐beam computed tomography (CBCT) and SyncTraX FX4; (4) the measurement of air kerma; (5) an end‐to‐end test.Results & DiscussionThe tests revealed the following. (1) All image quality evaluation items satisfied each acceptable criterion in all FPDs. (2) The maximum offsets among the centers were ≤0.40 mm in all combinations of the FPD and X‐ray tubes (preset). (3) The isocenter localization discrepancies between CBCT and preset #3 in the SyncTraX FX4 system were 0.29 ± 0.084 mm for anterior‐posterior, −0.19 ± 0.13 mm for superior‐inferior, 0.076 ± 0.11 mm for left‐right, −0.11 ± 0.066° for rotation, −0.14 ± 0.064° for pitch, and 0.072±0.058° for roll direction. the Pearson's product‐moment correlation coefficient between the two systems was >0.98 in all directions. (4) The mean air kerma value for preset #3 was 0.11 ± 0.0002 mGy in predefined settings (80 kV, 200 mA, 50 msec). (5) For 16 combinations of gantry and couch angles, median offset value in all presets was 0.31 mm (range 0.14–0.57 mm).ConclusionOur results demonstrate a competent performance of the SyncTraX FX4 system in terms of the localization accuracy for intracranial SRT.
Investigational Pharmacological Treatments for Vascular Calcification
Authors: Schantl Antonia E. , Ivarsson Mattias E. , Leroux Jean‐Christophe 
Published: October 2018

AbstractIn the past decade, significant progress has been made in understanding the medical threats posed by vascular calcification (VC). This recent development comes after a long history of misinterpreting this condition as a mere consequence of aging. As a result, there is presently no pharmacological treatment approved for the prevention or ablation of VC. Patients diagnosed with this chronic and debilitating condition are hence left at a great risk of experiencing serious cardiovascular events. Researchers, however, are ever better understanding the disease's pathophysiology, and promising avenues for drug development have emerged. In this review, recent clinical results of proposed calcification inhibitors are consolidated and selected investigational therapeutics are portrayed. Finally, opportunities for drug development approaches are highlighted and an objective account of challenges that remain in achieving this goal is provided.
[Co@Sn6Sb6]3−: An Off‐Center Endohedral 12‐Vertex Cluster
Authors: Wilson Robert J. , Hastreiter Florian , Reiter Kevin , Büschelberger Philipp , Wolf Robert , Gschwind Ruth M. , Weigend Florian , Dehnen Stefanie 
Published: October 2018

AbstractWe report on the asymmetric occupation of a 12‐vertex cluster centered by a single metal atom. Three salts of related intermetalloid cluster anions, [Co@Sn6Sb6]3− (1), [Co2@Sn5Sb7]3− (2), and [Ni2@Sn7Sb5]3− (3) were synthesized, which have pseudo‐C4v‐symmetric or pseudo‐D4h‐symmetric 12‐vertex Sn/Sb shells and interstitial Co− ions or Ni atoms. Anion 1 is a very unusual single‐metal‐“centered” 12‐atom cluster, with the inner atom being clearly offset from the cluster center for energetic reasons. Quantum chemistry served to assign atom types to the atomic positions and relative stabilities of this cluster type. The studies indicate that the structures are strictly controlled by the total valence electron count—which is particularly variable in ternary intermetalloid cluster anions. Preliminary 119Sn NMR studies in solution, supported by quantum‐chemical calculations of the shifts, illustrate the complexity regarding Sn:Sb distributions of such ternary systems.
Dynamic functional connectivity analysis reveals decreased variability of the default‐mode network in developing autistic brain
Authors: He Changchun , Chen Yanchi , Jian Taorong , Chen Heng , Guo Xiaonan , Wang Jia , Wu Lijie , Chen Huafu , Duan Xujun 
Published: October 2018

Accumulating neuroimaging evidence suggests that abnormal functional connectivity of the default mode network (DMN) contributes to the social‐cognitive deficits of autism spectrum disorder (ASD). Although most previous studies relied on conventional functional connectivity methods, which assume that connectivity patterns remain constant over time, understanding the temporal dynamics of functional connectivity during rest may provide new insights into the dysfunction of the DMN in ASD. In this work, dynamic functional connectivity analysis based on sliding time window correlation was applied to the resting‐state functional magnetic resonance imaging data of 28 young children with ASD (age range: 3–7 years) and 29 matched typically developing controls (TD group). In addition, k‐means cluster analysis was performed to identify distinct temporal states based on the spatial similarity of each functional connectivity pattern. Compared with the TD group, young children with ASD showed decreased dynamic functional connectivity variance between the posterior cingulate cortex (PCC) and the right precentral gyrus, which is negatively correlated with social motivation and social relating. Cluster analysis revealed significant differences in functional connectivity patterns between the ASD and TD groups in discrete temporal states. Our findings reveal that atypical dynamic interactions between the PCC and sensorimotor cortex are associated with social deficits in ASD. Results also highlight the critical role of PCC in the social‐cognitive deficits of ASD and support the concept that understanding the dynamic neural interactions among brain regions can provide insights into functional abnormalities in ASD. Autism Research 2018, 11: 1479–1493. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummarySocial cognitive dysfunction in autism spectrum disorder (ASD) is associated with dysfunction of the default mode network (DMN), a set of brain areas involved in various domains of social processing. We found that decreases in the dynamic functional connectivity variance between the posterior cingulate cortex and the sensorimotor cortex are associated with deficits in social motivation and social relating in young children with ASD. This result suggests that aberrations in the DMN and its dynamic interactions with other networks contribute to atypical integration of information with respect to self and others.
Adaptive trajectories and early risk factors in the autism spectrum: A 15‐year prospective study
Authors: Baghdadli Amaria , Michelon Cécile , Pernon Eric , Picot Marie‐Christine , Miot Stéphanie , Sonié Sandrine , Rattaz Cécile , Mottron Laurent 
Published: October 2018

Little is known about long‐term outcomes. We investigate the adaptive trajectories and their risk factors in ASD. Data were obtained from 281 children prospectively followed untill adulthood. The final sample consisted of 106 individuals. Vineland scores were collected at baseline (T1), 3 (T2), 10 (T3), and 15 (T4) years later. A group‐based method was used to identify homogeneous patterns of adaptive skills trajectories. Results show that among the children initially categorized as autistic, 82.6% remained over the ADOS diagnostic threshold, 11.9% converted to atypical autism, and 5.4% fell under the ADOS threshold. Most atypical autism diagnoses were unstable. Most (81.7%) autistic participants had an ID at inclusion. At T1, 59.3% were nonverbal, but only 39% at T4. Most changes occurred between 4 and 8 years of age. Approximately 25% of participants exhibited a “high” growth trajectory, in which progress continues throughout adolescence, and 75% a “low” growth trajectory, characterized by greater autistic symptoms, intellectual disability, and lower language abilities reflected by high CARS scores, low apparent DQ, and speech difficulties, which mostly, but not always, predicted low trajectories. Our findings suggest that the adaptive prognosis of autism is mostly poor in this cohort, biased toward intellectual disability. However, changes in diagnostic, speech, and adaptive status are not uncommon, even for indivduals with low measured intelligence or apparent intellectual disability, and are sometimes difficult to predict. Autism Research 2018, 11: 1455–1467. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryMost autism diagnoses given before 5 years of age are stable to adulthood, but one‐fifth of individuals are no longer considered to be autistic, even in a cohort biased toward apparent intellectual disability. Conversely, atypical autism diagnoses are mostly unstable. One‐third of children who are nonverbal at 5 years are verbal within 15 years, mostly before 8 years of age. Concerning adaptive behavior outcomes, only one‐fourth of children exhibit a high‐growth trajectory through at least 15 years.
Effect of electroconvulsive therapy on brain‐derived neurotrophic factor levels in patients with major depressive disorder
Authors: Sorri Annamari , Järventausta Kaija , Kampman Olli , Lehtimäki Kai , Björkqvist Minna , Tuohimaa Kati , Hämäläinen Mari , Moilanen Eeva , Leinonen Esa 
Published: October 2018

AbstractObjectivesBrain‐derived neurotrophic factor (BDNF) has been associated with depression and its treatment response. The aim of the present study was to explore the effect of electroconvulsive therapy (ECT) on serum and plasma BDNF levels and change of Montgomery–Asberg Depression Rating Scale (MADRS) and their associations in patients with major depressive disorder (MDD).MethodsThe study included thirty patients suffering from MDD. Their serum and plasma BDNF levels were examined before ECT (baseline) and after the first, fifth, and last ECT session. The severity of the depression and the response to ECT were measured with MADRS.ResultsElectroconvulsive therapy caused no significant changes in serum BDNF levels. Plasma BDNF levels decreased during the fifth ECT session between the baseline and the 2‐hr samples (p = 0.019). No associations were found between serum or plasma BDNF levels and remission. The correlations between plasma and serum BDNF levels in each measurement varied between 0.187 and 0.636.ConclusionsNeither serum nor plasma BDNF levels were systematically associated with the clinical remission. However, the plasma BDNF levels somewhat varied during the ECT series. Therefore, the predictive value of BDNF for effects of ECT appears to be at least modest.
Illustration of inversion‐recovery and Carr‐Purcell‐Meiboom‐Gill sequences by the determination of ethanol content in alcoholic beverages
Authors: Gossuin Yves , Vuong Quoc L. , Grunin Leonid , Van Nedervelde Laurence , Pietercelie Anne 
Published: October 2018

AbstractIn Nuclear Magnetic Resonance (NMR) education, the introduction of the relaxation phenomenon and the relaxation times (T1 and T2) is an important and compulsory step, as is the description of the Carr‐Purcell‐Meiboom‐Gill (CPMG) and inversion‐recovery (IR) measurement sequences. Indeed those sequences are still used nowadays for, respectively, the measurement of T2 and T1 but also in Magnetic Resonance Imaging (MRI) and NMR spectroscopy. Practical works with the students, performed for example with water, allow to illustrate this part of the teaching. In this work we propose an alternative and funny way to introduce these important topics. With a few microliters of a concentrated Gd3+ solution, a few milliliters of an alcoholic beverage and a low resolution and low field NMR device, it is possible, thanks to the relaxation phenomenon and using CPMG and IR sequences, to measure the alcohol content of the beverage provided that the alcohol proton exchange with water protons is taken into account. First the method is validated with synthetic water‐ethanol mixtures, then it is used to study nine different alcoholic beverages. The correlation of the ethanol volume fractions determined by NMR with the actual ethanol content of the beverages is rather good, especially for the method based on T2 relaxation, with a correlation coefficient r2 = 0.994. However, it seems that the method developed in this work always underestimates the ethanol volume fraction at high ethanol content for a reason which remains to be found.
The Role of Electronic Triplet States and High‐Lying Singlet States in the Deactivation Mechanism of the Parent BODIPY: An ADC(2) and CASPT2 Study
Authors: De Vetta Martina , González Leticia , Corral Inés 
Published: October 2018

AbstractThe potential tunability of the spectroscopic properties of the boron‐dipyrromethene (BODIPY) parent dye by suitable functionalization makes it attractive for a number of applications. The intrinsic remarkable fluorescence of the parent compound, which strongly competes with intersystem crossing to the triplet states, can be reverted by structural tuning of the BODIPY core, leading to BODIPY derivatives suitable for photodynamic therapy purposes. With the perspective of rationally designing BODIPY derivatives with enhanced intersystem crossing, the goal of this work is two‐fold: a) To investigate the main deactivation channels of the parent BODIPY following irradiation, paying particular attention to the accessibility of the triplet‐state potential energy surfaces, as well as the non‐radiative pathways involving the second brightest, most stable singlet electronic state S2, and b) to evaluate the performance of the computationally efficient second‐order algebraic‐diagrammatic construction scheme for the polarization propagator (ADC(2)) against the complete active space second‐order perturbation theory (CASPT2) method. Three singlet/triplet crossings were found, all of them with small spin−orbit couplings, with the S1/T2 crossing being the most plausible for the observed intersystem crossing yield. Methodologically, it is found that the ADC(2) method qualitatively reproduces the landscape of the potential energy profiles for the photophysical processes investigated; however, it systematically underestimates the energies of the stationary points and crossings of the same and different multiplicity, with the largest discrepancies found at S1/S0 crossing points. Our CASPT2 results provide a comprehensive picture of the landscape of the excited‐state potential energy surfaces of the parent BODIPY that might serve as a basis for the rational design of photosensitizers with a particular photophysical profile.
From the geological prognosis to the TBM drive: Planning the main construction lots of the Brenner Base Tunnel
Authors: Mair am Tinkhof Kurt , Radončić Nedim , Reinhold Chris , Insam Romed , Rehbock‐Sander Michael 
Published: October 2018

AbstractIt is state of the art to drive long tunnels in Alpine areas using hard rock TBMs. Mechanised tunnelling has much less flexibility than conventional excavation, so a deeper analysis of the available geological and geotechnical fundamentals is needed. In the course of planning the mechanised drives of the main tunnels on the Austrian side of the Brenner Base Tunnel, a detailed tunnelling concept was created, which deals with the project‐specific features and boundary conditions. The exploratory tunnel, which is used for geological and geotechnical exploration for the construction of the main tunnels, is currently being excavated. Through additional analyses, the geotechnical model could be verified and a reliable update of the rock parameters and the associated critical decisions has been achieved. All further specifications regarding TBM requirements, additional and auxiliary measures, support concept, bill of quantities and construction time model were based on the prognosis of system behaviour.
Hard rock tunnelling in Norway
Authors: Hörlein Norbert 
Published: October 2018

AbstractTunnelling in Scandinavia differs in several ways from the methods used in Central Europe. Porr Bau GmbH has been working since the end of 2016 with the subsidiary PNC on the first tunnelling project for the company in Norway. The project Fv.17 is located in Nordland, 10 km south of the Arctic Circle. The narrow coastal road is to be upgraded with two new tunnels. The Norwegian fjords are well known as vacation destinations and for their nature, but building tunnels in this environment is challenging, and the rock conditions are also demanding. The rock types described in the tender changed, leading to high water inflow. Systematic rock grouting needed to be carried out to finish the tunnel drive.
Selection and specification of a tunnel boring machine as the leading factor for the achievement of project goals
Authors: Flora Matthias , Jäger Manfred , Teuscher Peter 
Published: October 2018

AbstractFor almost all tunnelling jobs in the world – independent of continent or culture – the question has to be answered, which is the most suitable tunnelling method or in case of a mechanised tunnelling project the preferred tunnel boring machine to be used. Just the correct choice of a machine does not necessarily lead to the success of a project, which depends more on the design of the tunnel boring machine as well as the definition of measures to cope with all possible events during the advance. The core of the article constitutes a priori determined decision‐making process and the resulting guideline and intends to raise awareness of the critical criteria and parameters.
Rostro‐caudal organization of the human posterior superior temporal sulcus revealed by connectivity profiles
Authors: Cheng Chen , Fan Lingzhong , Xia Xiaoluan , Eickhoff Simon B. , Li Hai , Li Haifang , Chen Junjie , Jiang Tianzi 
Published: October 2018

AbstractThe posterior superior temporal sulcus (pSTS) plays an important role in biological motion perception but is also thought to be essential for speech and facial processing. However, although there are many previous investigations of distinct functional modules within the pSTS, the functional organization of the pSTS in its full functional heterogeneity has not yet been established. Here we applied a connectivity‐based parcellation strategy to delineate the human pSTS subregions based on distinct anatomical connectivity profiles and divided it into rostral and caudal subregions using diffusion tensor imaging. Subsequent multimodal connection pattern analyses revealed distinct subregional connectivity profiles. From this we inferred that the two subregions are involved in distinct functional circuits, the language processing loop and the cognition attention network. These results indicate a convergent functional architecture of the pSTS that can be revealed based on different types of connectivity and is reflected in different functions and interactions. In addition, when the subregions were performing their processing in the different functional circuits, we found asymmetry in the bilateral pSTS. Our findings may improve the understanding of the functional organization of the pSTS and provide new insights into its interactions and integration of information at the subregional level.
Improvement in colistin‐induced reproductive damage, apoptosis, and autophagy in testes via reducing oxidative stress by chrysin
Authors: Aksu Emrah Hicazi , Kandemir Fatih Mehmet , Küçükler Sefa , Mahamadu Amdia 
Published: October 2018

AbstractThis study aimed to investigate the effect of chrysin on colistin‐induced reproductive toxicity. Twenty‐eight adult male Sprague‐Dawley rats were divided into four groups of seven rats each. Group I received physiological saline for 7 days. Group II received 50 mg/kg/day chrysin for 7 days. Group III received a total dose of 73 mg/kg colistin for 7 days. Group IV received 50 mg/kg/day chrysin by an oral gavage after the colistin treatment. Colistin causes an increase in oxidative stress (OS) in the testis. Chrysin treatment significantly decreased the OS in the chrysin + colistin group compared with the colistin group. The highest caspase‐3 and LC3B expression levels were found in the colistin group and these levels were statistically lower in the chrysin + colistin group. Colistin treatment caused a decrease in sperm motility and an increase in sperm abnormality. Chrysin treatment mitigated these side effects significantly. In conclusion, chrysin treatment can be beneficial against colistin‐induced reproductive toxicity.