bluuebunny/crossref_metadata_2025_split huggingface dataset:
A scale and shift paradigm for sparse interpolation in one and more dimensions
Authors: Cuyt Annie , Lee Wen-shin 
Published: February 2019

Sparse interpolation from at least 2
n
uniformly spaced interpolation points

t
j

can be traced back to the exponential fitting method

[MATH HERE]
of de Prony from the 18-th century [5]. Almost 200 years later this basic problem is also reformulated as a generalized eigenvalue problem [8]. We generalize (1) to sparse interpolation problems of the form
[MATH HERE]
and some multivariate formulations thereof, from corresponding regular interpolation point patterns. Concurrently we introduce the wavelet inspired paradigm of dilation and translation for the analysis (2) of these complex-valued structured univariate or multivariate samples. The new method is the result of a search on how to solve ambiguity problems in exponential analysis, such as aliasing which arises from too coarsely sampled data, or collisions which may occur when handling projected data.
JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients
Authors: Guerrero-Preston Rafael , Lawson Fahcina , Rodriguez-Torres Sebastian , Noordhuis Maartje G. , Pirini Francesca , Manuel Laura , Valle Blanca L. , Hadar Tal , Rivera Bianca , Folawiyo Oluwasina , Baez Adriana , Marchionni Luigi , Koch Wayne M. , Westra William H. , Kim Young J. , Eshleman James R. , Sidransky David 
Published: February 2019

Abstract
To inform novel personalized medicine approaches for race and socioeconomic disparities in head and neck cancer, we examined germline and somatic mutations, immune signatures, and epigenetic alterations linked to neighborhood determinants of health in Black and non-Latino White (NLW) patients with head and neck cancer. Cox proportional hazards revealed that Black patients with squamous cell carcinoma of head and neck (HNSCC) with PAX5 (P = 0.06) and PAX1 (P = 0.017) promoter methylation had worse survival than NLW patients, after controlling for education, zipcode, and tumor–node–metastasis stage (n = 118). We also found that promoter methylation of PAX1 and PAX5 (n = 78), was correlated with neighborhood characteristics at the zip-code level (P &lt; 0.05). Analyses also showed differences in the frequency of TP53 mutations (n = 32) and tumor-infiltrating lymphocyte (TIL) counts (n = 24), and the presence of a specific C → A germline mutation in JAK3, chr19:17954215 (protein P132T), in Black patients with HNSCC (n = 73; P &lt; 0.05), when compared with NLW (n = 37) patients. TIL counts are associated (P = 0.035) with long-term (&gt;5 years), when compared with short-term survival (&lt;2 years). We show bio-social determinants of health associated with survival in Black patients with HNSCC, which together with racial differences shown in germline mutations, somatic mutations, and TIL counts, suggests that contextual factors may significantly inform precision oncology services for diverse populations.
T-cell Activity against AML Improved by Dual-Targeted T Cells Stimulated through T-cell and IL7 Receptors
Authors: Krawczyk Eric , Zolov Sergey N. , Huang Kevin , Bonifant Challice L. 
Published: February 2019

Abstract
The development of engineered T cells to treat acute myeloid leukemia (AML) is challenging due to difficulty in target selection and the need for robust T-cell expansion and persistence. We designed a T cell stimulated to kill AML cells based on recognition of the AML-associated surface marker CLEC12A, via secretion of a CLEC12AxCD3 bispecific “engager” molecule (CLEC12A-ENG). CLEC12A-ENG T cells are specifically activated by CLEC12A, are not toxic to hematopoietic progenitor cells, and exhibit antigen-dependent AML killing. Next, we coupled stimulation of T-cell survival to triggering of a chimeric IL7 receptor with an ectodomain that binds a second AML-associated surface antigen, CD123. The resulting T cells, identified as CLEC12A-ENG.CD123IL7Rα T cells, demonstrate improved activation upon dual target recognition, kill AML, and exhibit antitumor activity in xenograft models. Enhanced T-cell activation conferred by CD123.IL7Rα was dependent both on recognition of the CD123 target and on IL7Rα-mediated downstream signaling. Expression of a chimeric IL7R targeted to a second tumor-associated antigen (TAA) should improve T-cell activity not only against hematologic malignancies, but perhaps against all cancers.
Effect of Workflow Improvements in Endovascular Stroke Treatment
Authors: Janssen Paula M. , Venema Esmee , Dippel Diederik W.J. 
Published: February 2019

Background and Purpose—
Rapid initiation of endovascular stroke treatment is associated with better clinical outcome. The effect of specific improvements is not well known. We performed a systematic review and meta-analysis on the effectiveness of specific workflow improvements on time to treatment and outcome.

Methods—
A random-effects meta-analysis was used to evaluate the difference in mean time to treatment between intervention group and control group. Secondary outcomes included good functional outcome at 90 days (modified Rankin Scale score 0–2).

Results—

Fifty-one studies (3 randomized controlled trials, 13 prepost intervention studies, and 35 observational studies) with in total 8467 patients were included. Most frequently reported workflow intervention types concerned anesthetic management (n=26), in-hospital patient transfer management (n=14), and prehospital management (n=11). Patients in the intervention group had shorter time to treatment intervals (weighted mean difference, 26 minutes; 95% CI, 19–33;
P
<0.001) compared with controls. Subgroup meta-analysis of intervention types also showed a shorter time to treatment in the intervention group: a mean difference of 12 minutes (95% CI, 6–17;
P
<0.001) for anesthetic management, 37 minutes (95% CI, 22–52;
P
<0.001) for prehospital management, 41 minutes (95% CI, 27–54;
P
<0.001) for in-hospital patient transfer management, 47 minutes (95% CI, 28–67;
P
<0.001) for teamwork, and 64 minutes (95% CI, 24–104;
P
=0.002) for feedback. The mean difference in time to treatment of studies with multiple interventions implemented simultaneously was 50 minutes (95% CI, 31–69;
P
<0.001) in favor of the intervention group. Patients in the intervention group had increased likelihood of favorable outcome (risk ratio [RR], 1.39; 95% CI, 1.15–1.66;
P
<0.001).

Conclusions—
Interventions in the workflow of endovascular stroke treatment lead to a significant reduction in time to treatment and results in an increased likelihood of favorable outcome. Acute stroke care should be reorganized by making use of the examples of workflow interventions described in this review to ensure the best medical care for stroke patients.
Clinical Characteristics, Complications, and Reasons for Readmission following Lingual Tonsillectomy
Authors: Merna Catherine , Lin Harrison W. , Bhattacharyya Neil 
Published: February 2019

This brief communication regards the indications and complications for and rates of readmission following lingual tonsillectomy. The National Readmissions Database (NRD) 2013‐2014 was queried for all cases of lingual tonsillectomy occurring from 2013 to 2014. Among 602 lingual tonsillectomies (mean age 36.5 years, 58.2% male), the common indications for surgery were obstructive sleep apnea (58.7%), lingual tonsil hypertrophy/infection (18.8%), and neoplasia (15.9%). Overall, 49 (8.2%) of the cases were readmitted (95% confidence interval, 4.8%‐13.5%), with an average readmission duration of 3.0 days and average readmission cost of $25.4K. The most common diagnoses at readmission were bleeding (1.9% of all lingual tonsillectomy cases); dysphagia (1.7%); fever, nausea, vomiting, or diarrhea (1.6%); acute pain (1.6%); and airway obstruction (1.4%). There were no mortalities during primary or subsequent admissions. Lingual tonsillectomy across age groups is relatively free of adverse events, with overall readmission and complication rates similar to those of palatine tonsillectomy.
The Role of Cognitive Evaluation in Predicting Successful Audiometric Testing among Children
Authors: Teplitzky Taylor B. , Angster Kristen , Rosso Lauren E. , Ferruggiaro Anne R. , Isaiah Amal , Pereira Kevin D. 
Published: February 2019

ObjectiveTo determine the role of cognitive testing in predicting age‐appropriate audiometric responses among children aged 30 to 42 months.Study DesignProspective.SettingTertiary care audiology clinic.Subjects and MethodsSubjects included primary English–speaking children aged 30 to 42 months. A certified pediatric audiologist performed the cognitive aspect of the Developmental Assessment of Young Children–Second Edition (DAYC‐2). A second, blinded audiologist performed age‐appropriate audiometry. The raw, age‐equivalent, percentile, and standard DAYC‐2 scores were compared by agreement between speech reception threshold (SRT) and pure tone average (PTA). Optimal DAYC‐2 thresholds were also calculated for prediction of SRT‐PTA agreement and assessed for sensitivity, specificity, and positive and negative predictive values. P <. 05 was considered significant.ResultsComplete data were obtained from 37 children. The mean age was 34.9 months (95% CI, 33.5‐36.2), and 15 (41%) were female. Among the 37 children, 24 (65%) and 13 (35%) underwent visual reinforcement audiometry and conditioned play audiometry, respectively. SRT‐PTA agreement was seen in 32 (87%) tests. Mean DAYC‐2 raw score grouped by SRT‐PTA agreement was 39.4 versus 33.4 for nonagreement (2.8‐9.3, P <. 001). The mean age‐equivalent score grouped by SRT‐PTA agreement was 29.6 versus 23.0 for nonagreement (2.7‐10.6, P =. 002). Optimal cut points based on DAYC‐2 scores achieved moderate overall prediction performance (area under the curve, 0.73‐0.77) with a positive predictive value of 100%.ConclusionThe DAYC‐2 is a useful screen to identify children likely to complete an age‐appropriate audiogram.
Synthetic materials in art: a new comprehensive approach for the characterization of multi-material artworks by analytical pyrolysis
Authors: La Nasa Jacopo , Biale Greta , Sabatini Francesca , Degano Ilaria , Colombini Maria Perla , Modugno Francesca 
Published: February 2019

Abstract
Modern art materials introduced since the end of XIX century include a large number of formulations of synthetic polymers and pigments, whose degradation processes and best preservation conditions are a major issue in heritage science. Analytical pyrolysis coupled with gas chromatography and mass spectrometry (Py-GC/MS) is widely used for the characterisation of polymeric materials and organic pigments, however the interpretation of the pyrograms obtained from samples containing different analytes is not straightforward. To improve our understanding on how these materials behave in complex matrices, we used evolved gas analysis coupled with mass spectrometry (EGA-MS) and multi shot Py-GC/MS to highlight and analyse the different fractions in a sample from a pop-art made of painted polyurethane (PU) foam. The study represents a proof of concept to evaluate EGA-MS potential in studying composite modern art materials in combination with multi-shot pyrolysis. The aim of the investigation was establishing the composition of the PU formulation, the paint binder and the pigments, thereby contributing to planning the stabilisation and conservation of the object. The polymers and the class of synthetic organic pigments present in the paint were assessed by determining their specific pyrolysis products and through comparisons with data in the literature. EGA-MS analysis provided both thermal and chemical information in one analytical run, so that we could select four temperatures for use in multi-shot Py-GC/MS analysis and thus to selectively study the different fractions evolved at different temperatures. Information on the various components of the mixture was obtained, including additives and organic pigments, separating them on the basis of their different thermal degradation temperatures. The multianalytical approach included also non-destructive ATR-FTIR and enabled us to characterize in detail different synthetic materials: polyether-based polyurethane produced by the polyaddition of 2,6-diisocyanate toluene, hexamethylene diisocyanate and polypropylene glycol, vinyl paint, and a mixture of β-naphthol and mono-azo as pigments. HPLC–DAD and HPLC–ESI–MS analyses confirmed the pigments, and provided a positive identification of two β-naphthols (PO5 and PR1) and two monoazo pigments (PY1 and PY3).
Impact of tranexamic acid use on blood loss and transfusion rates following femoral varus derotational osteotomy in children with cerebral palsy
Authors: Nazareth A. , Shymon S. J. , Andras L. , Goldstein R. Y. , Kay R. M. 
Published: February 2019

Purpose Previous studies have established the safety and efficacy of tranexamic acid (TXA) in reducing blood loss after total joint arthroplasty and spinal fusion surgery; however, literature regarding the effectiveness of intraoperative TXA in children with cerebral palsy (CP) is limited. The aim of this study was to investigate the safety and efficacy of intraoperative TXA in reducing blood loss and transfusion requirements for children with CP undergoing a proximal femoral varus derotational osteotomy (VDRO). Methods This is a retrospective review of 258 children with CP who underwent VDRO performed at the author's institution between 2004 and 2017. In all, 36 subjects underwent VDRO surgery with administration of intravenous TXA and 222 subjects underwent VDRO without administration of TXA. Outcome measures including blood loss, transfusion requirements and venous thromboembolic events were compared between groups using t-tests and chi-squared tests. Results No significant differences were seen in the rates of transfusion between groups for the entire hospitalization (TXA group: 11.1% versus No TXA group: 19.8%), intraoperatively (TXA: 2.8% versus No TXA: 9.0%) or postoperatively (TXA: 8.3% versus No TXA: 14.4%). Intraoperative estimated blood loss (TXA: 144.4 mL versus No TXA: 159.0 mL) and percentage blood loss (TXA: 8.9% versus No TXA: 9.2%) were similar between groups. No major thromboembolic complications events occurred in either group. Conclusion The use of TXA was not associated with thromboembolic complications in this series of children with CP undergoing VDRO surgery. Though there was a trend toward lower rates of intraoperative and postoperative blood transfusion with TXA use in these patients, the differences were not significant, possibly due to low estimated blood loss in both groups and sample size. Level of evidence III- retrospective comparative study
Recovering the human in the urban dystopia: Mobility as détournement in Playtime
Authors: Spalding Steven 
Published: February 2019

Abstract
This project is a re-assessment of Jacques Tati’s Playtime that displaces the predominant view of Tati as a pantomime and comedian. Playtime instead reveals Tati’s profound engagement with modern urban design, spatial practices and critique. Tati’s film explores how the urban spaces of contemporary France represent a distinct challenge to understanding and experience. Through the singular trajectory of his famous protagonist Hulot, Tati articulates an urban wandering or flânerie that resembles what the Situationists termed as dérive, a kind of movement through the city capable of opening up new ways of seeing and experiencing urban spaces. Hulot’s dérive mobility comes to inform the way in which the camera moves as it captures Tativille. As Hulot drifts through the traffic-clogged streets, labyrinthine office buildings and glass-box apartments of Playtime’s Tativille, at stake is a mode of urban experience able to overcome urban dislocation, alienation and separation.
Automobiles and gender in San Francisco crime films
Authors: Stangl Paul 
Published: February 2019

Abstract
Throughout American history, cultural norms regarding the behaviour of men and women in public space have extended to their use of transportation, including the automobile. A series of crime films set in San Francisco spanning seven decades are examined in relation to these norms and how this has changed over decades. While Lefebvre observes a potential for art and culture to facilitate social change, these movies largely reinforce stereotypes about men, women and cars.
All that is solid? Movement, repurposed lives and a cardboard citizenry
Authors: Zheng Connie 
Published: February 2019

Abstract
This article situates cardboard as a material lens through which to trace, and make visible, the flows of capital within a Trans-Pacific circuitry of trade, and to point to the political potentials enabled by the reuse and re-imagining of cardboard by groups of people who have been made invisible within the prevailing regime of labour. I argue that tracing the circulation of cardboard through the Bay Area – with a stop in Hong Kong – can become a laboratory for thinking through how the re-visibilization of capital and material flows can change the way that we think about the political and how the political is constructed or remade. To take this argument further, I posit that we may use this knowledge and project it into the production of a new symbolic and political space, in which cardboard acts as a potentially unifying material of protest for a new global corpus – a cardboard citizenry. Can a ‘cardboard citizenry’ act as a stateless, dynamic body of protest that oozes out from the circuitry of Trans-Pacific trade to create a new global citizenry, one that is able to make any space inhabitable and subsequently privileges creativity over market efficiency, the informal over the formal, the ephemeral over the permanent?
Hyperventilation in Children with Dengue Hemorrhagic Fever (DHF)
Authors: A. Kasim Y. , Rini K. E. Anky Tri , S. P. S. Sumarmo 
Published: February 2019

Many studies of Dengue Hemorrhagic Fever (DHF) have been done but only a few revealed the respiratory status. Respiratory problems arise. because of plasma leakage through the 'damaged capillaries, causing lung edema and in turn result in hypoxemia. This later on will be compensated by a hyperventilation state.
During a 6-month-period (May to September 1988), two aspects were studied in 85 patients hospitalized with DHF. First, the ventilatory pattern and second, the result of giving oxygen support in improving the respiratory disturbance, in this case alveolar hyperventilation.
The incidence of alveolar hyperventilation in DHF grade II (DHF II) and Dengue Shock Syndrome (DSS) differed significantly. Hypoxemia occurred in DHF II and DSS with no significant differences. The difference of the incidence of metabolic acidosis in DHF II and DSS were significant.
In DHF II patients having had hyperventilation state, oxygen therapy decreased respiration rate significantly and increased the PaC02 though not significantly.
Acute Non Lymphoblastic Leukemia in the Department of Child Health School of Medicine, University of North Sumatera/ Dr. Pirngadi Hospital Medan (1983-1988): A Preliminary Study
Authors: Nasution Feraluna , Arifin Zairul , Sutjipto Adi 
Published: February 2019

A retrospective study on Acute Non Lymphoblastic Leukemia (ANLL) was conducted at the Sub Division of Pediatric Hematology, School of Medicine, University of North Sumatera/Dr. Pirngadi Hospital Medan, in a period of 5 years (1983-1988).
There were 18 cases consisted of 14 (77. 78%) males and 4 (22 .22%) females with the age group of 0-2 years: 6 (30%), 2-8 years: 9 (50%), 8-15 years: 3 (30%). By the FAB classification, they were of FAB M-1: 1 (5.55%), FAB M-2: 1 (5.55%), FAB M-3: 1 (5.55%), FAB M-4: 2 (11.12%) and FAB M-6: 13 (72.23%). Only 7 (38.88%) were treated with cytostatics while the others received only supportive therapy. The result of cytostatic treatment was unsatisfactory: 4 (57.14%) died within the first 2 months of treatment, 3 (42.86%) discontinued their cytostatics treatment.
Bronchopneumonia with measles in Infants and Children at the Department of Child Health School of Medicine, University of North Sumatera/ Dr. Pirngadi Hospital Medan (January 1985 - December 1989)
Authors: Hutasoit Charles , Dj. Mardiana K. , Daulay Ridwan M. , Lubis Helmi M. , Siregar Zakaria 
Published: February 2019

A retrospective study was done on patients with bronchopneumonia hospitalized at the Dr. Pirngadi Hospital Medan/School of Medicine, University of North Sumatera; during January 1985 through December 1989.
The purpose of this study is to assess the morbidity and mortality of bronchopneumonia with measles and the nutritional status of the patients.
Out of the 14.082 patients admitted, 1310 children suffered from bronchopneumonia (10.7%). Ninety nine of them were also with measles (7.6%).
Most of the patients with bronchopneumonia without measles were in the age group 0-1 year (58.7%). The mortality waas 24.8% and the highest mortality rate was in the age group of 4-5 years (34.6%).
Most of the patients with bronchopneumonia and measles were in the age group of 1-2 years (30.3%). The mortality rate of bronchopneumonia with measles was 22.2% and the highest mortality rate was in the age group of 3-4 years (35. 7%).
Bronchopneumonia with or without measles occurred more in malnourished patients rather than in well-nourished cases.
All of the patients who had bronchopneumonia with measles in the present study had never been immunized against measles.
Gastroenteritis in Patients Hospitalized at the Pediatric Ward of Dr. Pirngadi Hospital Medan
Authors: Lubis Gustina , Thaib Tm. , Sinuhaji Atan Baas , Sutanto A. H. 
Published: February 2019

In 1989, oj2350 patients hospitalized in the paediatric ward of Dr. Pirngadi Hospital, Medan, 829 (35.3%) were gastroenteritis cases, with male more than female. Most of the patients with gastroenteritis were found in the age group of under 1 years (521 cases = 62.8%). The highest prevalence was found in january, February and March.
Mild, moderate and severe dehydration were encountered in 2. 7%, 83.1% and 14.2% cases respectively.
Eighty for (10.1%) cases had been treated with oralit before admission. Only 49. 1% of those patients with gastroenteritis under two years of age were breastfed. The patients of under five year old were 791 (95. 4%) cases; 259 (32. 7%) cases were malnourished.
The overall mortality rate of these patients with gastroenteritis was 5.9% ( 49 cases). The age specific mortality rate was highest in the age group of 6- 12 months. Usually patients died with gastroenteritis had complications or associated diseases.
Thrombocytopenia in Dengue Hemorrhagic Fever
Authors: Sunarto Sunarto , Sutaryo Sutaryo 
Published: February 2019

According to WHO thrombocytopenia is one of the diagnostic criteria of DHF. On the other hand many studies have reported DHF cases without evidence of thrombocytopenia.
One hundred fifty nine DHF out of485 suspected cases were assessed for their platelet counts. Diagnosis of DHF was established based on the WHO criteria, and confirmed by the hemagglutination inhibition test. The platelet counts were done serially and intensively by phase contrast microscope from the first day of hospitalization until the patient's discharge.
In 77 patients thrombocytopenia appeared for the first time during hospitalization. Mild thrombocytopenia appeared in almost all of these cases before thrombocyte count of 100,000 reached. Seventy two patients had shown thrombocytopenia on the day of admission. No thrombocytopenia was found on the second day of illness, the earliest time of the detection of thrombocytopenia was on the Jrri and the latest was on the 8th day of illness. Thrombocytopenia lasted 1-5 days. It is concluded that many DHF diagnosis would have been missed if the thrombocyte investigation had not been done serially and intensively. Mild thrombocytopenia in DHF suspected patients should call attention to do platelet investigation intensively in those cases.