bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining Primary Care Physician Information Needs to Inform Ambulatory Visit Note Display
Authors: Clarke M.A. , Steege L.M. , Moore J.L. , Koopman R.J. , Belden J.L. , Kim M.S. 
Published: October 2018

Summary
Background: With the increase in the adoption of electronic health records (EHR) across the US, primary care physicians are experiencing information overload. The purpose of this pilot study was to determine the information needs of primary care physicians (PCPs) as they review clinic visit notes to inform EHR display.
Method: Data collection was conducted with 15 primary care physicians during semi-structured interviews, including a third party observer to control bias. Physicians reviewed major sections of an artificial but typical acute and chronic care visit note to identify the note sections that were relevant to their information needs. Statistical methods used were McNemar-Mosteller’s and Cochran Q.
Results: Physicians identified History of Present Illness (HPI), Assessment, and Plan (A&P) as the most important sections of a visit note. In contrast, they largely judged the Review of Systems (ROS) to be superfluous. There was also a statistical difference in physicians’ highlighting among all seven major note sections in acute (p = 0.00) and chronic (p = 0.00) care visit notes.
Conclusion: A&P and HPI sections were most frequently identified as important which suggests that physicians may have to identify a few key sections out of a long, unnecessarily verbose visit note. ROS is viewed by doctors as mostly “not needed,” but can have relevant information. The ROS can contain information needed for patient care when other sections of the Visit note, such as the HPI, lack the relevant information. Future studies should include producing a display that provides only relevant information to increase physician efficiency at the point of care. Also, research on moving A&P to the top of visit notes instead of having A&P at the bottom of the page is needed, since those are usually the first sections physicians refer to and reviewing from top to bottom may cause cognitive load.
Citation: Clarke MA, Steege LM, Moore JL, Koopman RJ, Belden JL, Kim MS. Determining primary care physician information needs to inform ambulatory visit note display. Appl Clin Inf 2014; 5: 169–190http://dx.doi.org/10.4338/ACI-2013-08-RA-0064
A tannic extract for oral and topical treatment of CVI and haemorrhoids
Authors: Rohdewald P. 
Published: October 2018

SummaryThe present review summarizes investigations concerning the biological activity as well as the clinical actions of an extract from the bark of the French maritime pine, Pycnogenol®, on the signs and symptoms of the chronic venous insufficiency (CVI). Basis for the anti-oedema and anti-thrombotic action is the maintenance of endothelial health, the capillary sealing, the inhibition of platelet aggregation and the anti-inflammatory and anti-oxidative action of Pycnogenol® following oral and/or local administration. The improvement of microcirculation contributes to faster healing of ulcers and haemorrhoids. The inhibition of oedema formation of the lower limbs and deep vein thromboses was demonstrated after long haul flights. The comparison with some venotonics and elastic stockings demonstrated superior effects of Pycnogenol®. Mild unwanted effects were reported with a rate of about 1 %.
Primäre Varikose und venöse Malformation im Genitalbereich
Authors: Loose D. A. , Faerber G. , Weber J. 
Published: October 2018

ZusammenfassungDie Pathogenese der primären Varikose und besonders auch der congenitalen vaskulären Malformationen im Genitalbereich ist bestimmt durch hämodynamische und hormonelle Faktoren. Sowohl eine primäre Varikose als auch eine sekundäre Varikose bei Gonadalveneninsuffizienz können zu ausgedehnten Vulvavarikositäten mit erheblichen Stauungsbeschwerden führen (Pelvines Stauungssyndrom).Congenitale venöse Malformationen im Genitalbereich treten sowohl isoliert als auch in Verbindung mit venösen Malformationen der benachbarten Regionen auf und sollten so früh wie möglich behandelt werden. Entsprechend sind in den vergangenen Jahren unterschiedliche Behandlungstaktiken erarbeitet worden, wobei aktuell nach der interventionell radiologischen Okklusionsbehandlung der Gonadalveneninsuffizienz die Sklerotherapie der Vulvavarikositäten primär oder in Ergänzung mit der gefäßchirurgischen Extirpation der Venektasien zu empfehlen ist. Das betrifft auch die venösen Malformationen im Genitalbereich.
Biomedical Data Mining
Authors: Combi C. , Tucker A. , Peek N. 
Published: October 2018

Summary
Objective: To introduce the special topic of Methods of Information in Medicine on data mining in biomedicine, with selected papers from two workshops on Intelligent Data Analysis in bioMedicine (IDAMAP) held in Verona (2006) and Amsterdam (2007).
Methods: Defining the field of biomedical data mining. Characterizing current developments and challenges for researchers in the field. Reporting on current and future activities of IMIA’s working group on Intelligent Data Analysis and Data Mining. Describing the content of the selected papers in this special topic.
Results and Conclusions: In the biomedical field, data mining methods are used to develop clinical diagnostic and prognostic systems, to interpret biomedical signal and image data, to discover knowledge from biological and clinical databases, and in biosurveillance and anomaly detection applications. The main challenges for the field are i) dealing with very large search spaces in a both computationally efficient and statistically valid manner, ii) incorporating and utilizing medical and biological background knowledge in the data analysis process, iii) reasoning with time-oriented data and temporal abstraction, and iv) developing end-user tools for interactive presentation, interpretation, and analysis of large datasets.
Skelettszintigraphie
Authors: Bares R. , Brenner W. , Kirsch C.-M. 
Published: October 2018

ZusammenfassungDiese Leitlinie soll eine an der Praxis orientierte Hilfestellung bei der Indikationsprüfung, Durchführung und Beurteilung der Skelettszintigraphie liefern. Ausgehend von den pathophysiologischen und pharmakologischen Grundlagen wird eine Übersicht über die methodischen Variationen der Skelett - szintigraphie incl. der Anwendung neuer Messtechniken gegeben, an die sich eine detaillierte Aufzählung der gesicherten Indikationen anschließt. Es folgt die Beschreibung der konkreten Vorgehensweise, zu der die Patientenvorbereitung, Anamnese-Erhebung, Beachtung der Kontraindikationen, Auswahl des geeigneten Radiopharmakons (incl. Dosierung und Abschätzung der Strahlenexposition) sowie die Festlegung der Datenakquisition unter Einschluss etwaiger Interventionen gehört. Komplettiert wird diese Beschreibung durch Angaben zur Datenauswertung (Nachbearbeitung), Befundung und Berichterstellung incl. Dokumentation. Schließlich werden auch die Qualitätssicherung und mögliche Quellen für Fehlbefunde dargestellt sowie Zukunftsperspektiven anhand offener Fragen beleuchtet.
Health Information Search to Deal with the Exploding Amount of Health Information Produced
Authors: Hanbury A. , Al Shorbaji N. , Müller H. 
Published: October 2018

Summary
Objectives: This focus theme deals with the various aspects of health information search that are necessary to cope with the challenges of an increasing amount and complexity of medical information currently produced.
Methods: This editorial reviews the main challenges of health information search and summarizes the five papers of this focus theme.
Results and Conclusions: The five papers of the focus theme cover a large part of the current challenges in health information search such as coding standards, information extraction from complex data, user requirements analysis, multimedia data analysis and the access to big data. Several future challenges are identified such as the combination of visual and textual data for information search and the difficulty to scale when analyzing big data.
Know Thyself
Authors: Beuscart R. 
Published: October 2018

SummaryThis article is part of a For-Discussion-Section of Methods of Information in Medicine on “Biomedical Informatics: We Are What We Publish” written by Peter L. Elkin, Steven H. Brown, and Graham Wright. It is introduced by this editorial and followed by a commentary paper with invited comments. In their paper, P. Elkin et al. attempt to define the fields of Medical Informatics and Bioinfor matics through a bottom-up approach by searching the medical literature. This innovative approach provides interesting results that are discussed in the commentary paper. In subsequent issues the discussion may continue through letters to the editor.
Discussion of “Biomedical Infor -matics: We Are What We Publish”
Authors: de Quirós F. G. B. , Geissbuhler A. , Hammond W. E. , Hasman A. , Hussein R. , Koppel R. , Kulikowski C. A. , Maojo V. , Martin-Sanchez F. , Moorman P. W. , Moura L. A. , Schuemie M. J. , Smith B. , Talmon J. 
Published: October 2018

SummaryThis article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "Biomedical Informatics: We Are What We Publish", written by Peter L. Elkin, Steven H. Brown, and Graham Wright. It is introduced by an editorial. This article contains the combined commenta -ries invited to independently comment on the Elkin et al. paper. In subsequent issues the discussion can continue through letters to the editor.
Commentaries on “Informatics and Medicine: From Molecules to Populations”
Authors: Altman R. B. , Balling R. , Brinkley J. F. , Coiera E. , Consorti F. , Dhansay M. A. , Geissbuhler A. , Hersh W. , Kwankam S. Y. , Lorenzi N. M. , Martin-Sanchez F. , Mihalas G. I. , Shahar Y. , Takabayashi K. , Wiederhold G. 
Published: October 2018

Summary

Objective:
To discuss interdisciplinary research and education in the context of informatics and medicine by commenting on the paper of Kuhn et al. “Informatics and Medicine: From Molecules to Populations”.

Method:
Inviting an international group of experts in biomedical and health informatics and related disciplines to comment on this paper.

Results and Conclusions:
The commentaries include a wide range of reasoned arguments and original position statements which, while strongly endorsing the educational needs identified by Kuhn et al., also point out fundamental challenges that are very specific to the unusual combination of scientific, technological, personal and social problems characterizing biomedical informatics. They point to the ultimate objectives of managing difficult human health problems, which are unlikely to yield to technological solutions alone. The psychological, societal, and environmental components of health and disease are emphasized by several of the commentators, setting the stage for further debate and constructive suggestions.
The Effect of Tibial Plateau Levelling Osteotomy on Stifle Extensor Mechanism Load: A Canine Ex Vivo Study
Authors: Glyde Mark , Hosgood Giselle , Hayes Alex , Drew Jarrod 
Published: October 2018

Objective To evaluate the effect of tibial plateau levelling osteotomy on stifle extensor mechanism load in an ex vivo cruciate-intact canine cadaveric model.
Study Design Ex vivo mechanical testing study.
Animals Cadaveric canine pelvic limbs (n = 6).
Materials and Methods A 21-mm tibial radial osteotomy was performed on pelvic limbs (n = 6) prior to being mounted into a load-bearing limb press. The proximal tibial segment was incrementally rotated until the anatomical tibial plateau angle had been rotated to at least 1°. The proportional change in stifle extensor mechanism load between the anatomical tibial plateau angle and the neutralized (∼6.5 degrees) and over-rotated (∼1°) tibial plateau angle was analysed using a one-sample t-test against a null hypothesis of no change. A p-value ≤0.05 was considered significant.
Results There was no significant change in the stifle extensor mechanism load from the anatomical tibial plateau angle (308 N [261–355 N]) to the neutralized tibial plateau angle (313 N [254–372 N]; p =.81), or from the anatomical tibial plateau angle to the over-rotated tibial plateau angle (303 N [254–352 N; p = 0.67).
Conclusion Tibial plateau levelling osteotomy does not significantly alter stifle extensor mechanism load at either a neutralized or over-rotated tibial plateau angle in our cruciate-intact model.
Iod-131-Ganzkörperszintigraphie beim differenzierten Schilddrüsenkarzinom
Authors: Verburg Frederik , Grünwald Frank , Lassmann Michael , Hänscheid Heribert , Luster Markus , Dietlein Markus 
Published: October 2018

ZusammenfassungDie Version 4 der Verfahrensanweisung für die Iod-131-Ganzkörperszintigraphie beim differenzierten Schilddrüsenkarzinom ist ein Update der Version 3, die im Jahr 2007
durch die Deutsche Gesellschaft für Nuklearmedizin (DGN) und die Deutsche Gesellschaft für Medizinische Physik (DGMP) publiziert wurde. Diese Verfahrensanweisung
beschreibt mit primärer Zielsetzung die fachgerechte Durchführung der Ganzkörperszintigraphie nach Applikation einer diagnostischen bzw. therapeutischen I-131-Aktivität.
Die aktualisierten Indikationen zur I-131-Ganzkörperszintigraphie werden in der Verfahrensanweisung aufgelistet. Neue Erkenntnisse bezüglich der Beziehung zwischen
verabreichter Aktivität und Bildqualität wurden in der aktualisierten Verfahrungsanweisung berücksichtigt. Die Verfahrensanweisung wurde von einer repräsentativen
Expertengruppe im Konsensverfahren verabschiedet. Sie entspricht damit einer Verfahrensanweisung der ersten Stufe (S1) nach den Kriterien der Arbeitsgemeinschaft der
Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Zusätzlich wurden Indikationsstellung, Zeitpunkt und Aktivitätswahl für die diagnostische
Ganzkörperszintigraphie im erweiterten Kollegenkreis am 30. November 2012, am 19. April 2013 und am 23. April 2015 bei Tagungen der Arbeitsgemeinschaft Schilddrüse der
Deutschen Gesellschaft für Nuklearmedizin ausführlich diskutiert.
Variations in Cochlear Size of Cochlear Implant Candidates
Authors: Zahara Devira , Dewi Rima Diana , Aboet Askaroellah , Putranto Fikri Mirza , Lubis Netty Delvrita , Ashar Taufik 
Published: October 2018

Introduction The cochlear anatomy varies in each individual, and that has an impact on decisions regarding the insertion of electrodes. The measurement of the cochlear size is the routine examination required to choose the proper cochlear implant (CI) electrodes.
Objective To acquire normative data on the size of the cochlea (length, width, height, scala timpani [ST] height, cochlear duct length [CDL]) of CI candidates in Medan, Indonesia.
Methods This descriptive study was conducted based on high-resolution computed tomography (HRCT) temporal bone data and on HRCT temporal data manipulated to reconstruct three-dimensional (3D) multiplanar images with OsiriX MD DICOM Viewer version 9.5.1 (Pixmeo SARL, Bernex, Geneva, Switzerland) viewer of 18 patients (36 ears) who were CI candidates in Medan, Indonesia, in order to determine cochlear length (A), cochlear width, cochlear height, ST height and CDL, calculated through a simple mathematical function.
Results The average cochlear length (A) was 8.75 mm (standard deviation [SD] = 0.31 mm); the average cochlear width was 6.53 mm (SD = 0.35 mm); the average cochlear height was 3.26 mm (SD = 0.24 mm) and the average ST height at the basal cochlea was 1.00 mm (SD = 0.1 mm); and 0.71 mm (SD = 0.1 mm) at the half turn of cochlea. The average total CDL was 32.45 mm (SD = 1.31 mm; range: 30.01–34.83 mm).
Conclusion The cochlear size varies in each individual; therefore, the temporal bone measurement of CI candidates using HRCT is essential: for the selection of suitable implant electrodes; to minimize cochlear damages at the insertion of the electrode arrays; and to maximize the hearing improvements.
Comparing Individuals through the Speech Recognition Test Applied to Regional Live Voice and Recorded Speeches from Paraná State in Five Brazilian Counties
Authors: Mafra Nicoli Valverde , Ribas Angela , Moretti Claudia , Zeigelboim Bianca Simone , Fonseca Vinicius Ribas , Borburema Rodrigo Marques 
Published: October 2018

Introduction Speech tests such as logoaudiometry measure the ability to perceive and recognize oral sounds. The Speech Recognition Index (SRI) is one of the speech tests adopted in clinical routine; it uses standardized live voice and recorded speeches. The live voice speech method can be influenced by intra and interspeaker variability, as well as by regionalism variability, whereas recorded tests show consistency in their presentation.
Objective Analyzing results of the SRI test applied to live voice and recorded speeches from Paraná State, in different Brazilian counties.
Method The sample comprised 125 individuals, 25 from each county (Rio de Janeiro, Florianópolis, Porto Alegre, Salvador and Curitiba), from both sexes, in the age group 20 to 70 years; the SRI was applied in both techniques.
Results The recorded speech method showed prevalence of hit improvement in Rio de Janeiro (40%), Salvador, Porto Alegre and Florianópolis (28%). Individuals from Salvador and Florianópolis subjected to the recorded speech method showed better results in the left ear. Individuals from Rio de Janeiro and Porto Alegre showed satisfactory results in both ears, whereas those from Curitiba did not show statistically significant difference between the left and the right ear.
Conclusion The recorded CD application method showed prevalence of hit improvement (%) in the SRI responses in comparison to the live voice speech technique in most of the studied counties. According to the hit rate measured in the herein investigated counties, Rio de Janeiro showed the best results in the recorded speech method.
Inferior Vena Cava Thrombus due to Left Inferior Vena Cava and Ulcerative Colitis
Authors: Arai Hirofumi , Mizukami Akira , Yoshioka Kenji , Kuroda Shunsuke , Iwatsuka Ryota , Hayashi Tatsuya , Kimura Shigeki , Matsumura Akihiko 
Published: October 2018

AbstractA 29-year-old man with diarrhea and abdominal pain for 2 weeks presented with new-onset left back pain. Contrast-enhanced computed tomography (CT) showed a left inferior vena cava (IVC) crossing over the aorta, and thrombus in the IVC and left renal vein. Colonoscopy and biopsy for assessment of diarrhea and abdominal pain provided a diagnosis of ulcerative colitis. Stasis of blood flow due to left IVC crossing over the aorta, and hypercoagulability due to ulcerative colitis influenced thrombus formation.
User Testing an Information Foraging Tool for Ambulatory Surgical Site Infection Surveillance
Authors: Karavite Dean , Miller Matthew , Ramos Mark , Rettig Susan , Ross Rachael , Xiao Rui , Muthu Naveen , Localio A. , Gerber Jeffrey , Coffin Susan , Grundmeier Robert 
Published: October 2018

Background Surveillance for surgical site infections (SSIs) after ambulatory surgery in children requires a detailed manual chart review to assess criteria defined by the National Health and Safety Network (NHSN). Electronic health records (EHRs) impose an inefficient search process where infection preventionists must manually review every postsurgical encounter (< 30 days). Using text mining and business intelligence software, we developed an information foraging application, the SSI Workbench, to visually present which postsurgical encounters included SSI-related terms and synonyms, antibiotic, and culture orders.
Objective This article compares the Workbench and EHR on four dimensions: (1) effectiveness, (2) efficiency, (3) workload, and (4) usability.
Methods Comparative usability test of Workbench and EHR. Objective test metrics are time per case, encounters reviewed per case, time per encounter, and retrieval of information meeting NHSN definitions. Subjective measures are cognitive load using the National Aeronautics and Space Administration (NASA) Task Load Index (NASA TLX), and a questionnaire on system usability and utility.
Results Eight infection preventionists participated in the test. There was no difference in effectiveness as subjects retrieved information from all cases, using both systems, to meet the NHSN criteria. There was no difference in efficiency in time per case between the Workbench and EHR (8.58 vs. 7.39 minutes, p = 0.36). However, with the Workbench subjects opened fewer encounters per case (3.0 vs. 7.5, p = 0.002), spent more time per encounter (2.23 vs. 0.92 minutes, p = 0.002), rated the Workbench lower in cognitive load (NASA TLX, 24 vs. 33, p = 0.02), and significantly higher in measures of usability.
Conclusion Compared with the EHR, the Workbench was more usable, short, and reduced cognitive load. In overall efficiency, the Workbench did not save time, but demonstrated a shift from between-encounter foraging to within-encounter foraging and was rated as significantly more efficient. Our results suggest that infection surveillance can be better supported by systems applying information foraging theory.
Novel indole and benzothiophene ring derivatives showing differential modulatory activity against human epithelial sodium channel subunits, ENaC β and γ
Authors: Kasahara Yoichi , Sakurai Takanobu , Matsuda Ryusei , Narukawa Masataka , Yasuoka Akihito , Mori Naoki , Watanabe Hidenori , Okabe Takayoshi , Kojima Hirotatsu , Abe Keiko , Misaka Takumi , Asakura Tomiko 
Published: October 2018

ABSTRACT
The epithelial sodium channel (ENaC) plays a pivotal role in sodium homeostasis, and the development of drugs that modulate ENaC activity is of great potential therapeutic relevance. We screened 6100 chemicals for their ability to activate sodium permeability of ENaC. We used a two-step strategy: a high throughput cell-based assay and an electrophysiological assay. Five compounds were identified showing common structural features including an indole or benzothiophene ring. ENaC consists of three subunits: α, β, and γ. Changing the heteromeric combination of human and mouse ENaC αβγ subunits, we found that all five compounds activated the human β subunit but not the mouse subunit. However, four of them exhibited lower activity when the human γ subunit was substituted by the mouse γ subunit. Our findings provide a structural basis for designing human ENaC activity modulators.
Abbreviations: ENaC: Epithelial sodium channel; ΔRFU: delta relative fluorescence units; EC50: Half-maximal effective concentration; Emax: maximum effect value.
Bilateral supplementary comparison of cryogenic radiometers SIM.PR-S3
Authors: Yoon H W , Shaw P S , Menegotto T , Almeida G F B de 
Published: October 2018

NIST (USA) and INMETRO (Brazil) performed a bilateral supplementary comparison of cryogenic radiometers. The subject of this comparison is to give metrological equivalence to the measurement of optical power performed at Inmetro, using the reference value of this quantity derived from CCPR–S3 comparison. Each NMI provided two detectors - silicon-based 3-photodiode, reflectance trap detectors - for this bilateral comparison. Those detectors were measured at nominal wavelengths of 457.9 nm and 514.5 nm of Ar+; 632.8 nm of HeNe by each laboratory. The results for both institutes agree under the normalized error criterion. The results of this comparison also show agreement with a combined standard uncertainty of 6.1 parts per 104 and the differences to the CCPR-S3 reference value were -1.7 and -6.1 parts in 104.
KEY WORDS FOR SEARCH
Cryogenic radiometers, Supplementary Comparison

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCPR, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).