bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osimertinib: A Novel Dermatologic Adverse Event Profile in Patients with Lung Cancer
Authors: Chu Chia-Yu , Choi Jennifer , Eaby-Sandy Beth , Langer Corey J. , Lacouture Mario E. 
Published: April 2018

Abstract

Dermatologic adverse events (dAEs) are common with the use of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy. First- and second-generation agents (erlotinib, gefitinib, and afatinib) are frequently associated with acneiform rash, pruritus, xerosis, and paronychia; the incidence and characterization of these dAEs have been well described. However, there is evidence that the dAE profile is different with third-generation EGFR-TKIs. Herein, we describe the dAEs associated with third-generation EGFR-TKIs and our clinical experience with osimertinib, a third-generation EGFR-TKI approved by the U.S. Food and Drug Administration for the treatment of metastatic, EGFR T790M mutation-positive non-small cell lung cancer in patients whose disease has progressed on or after EGFR-TKI therapy. Case summaries of patients from two of our institutions who received osimertinib and were referred to a dermatologist for dAEs are also presented. Overall, the evidence suggests that osimertinib is associated with less severe and less frequent dAEs than first- and second-generation EGFR-TKIs and that therefore a different approach is warranted. Finally, we outline dAE management approaches for osimertinib in the context of those typically employed with first- and second-generation EGFR-TKIs.

Implications for Practice
Appropriate prevention and management of dermatologic adverse events (dAEs) associated with the use of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) may help patients to continue therapy and lessen any negative impact on their quality of life. EGFR-TKIs are frequently associated with acneiform rash, pruritus, xerosis, and paronychia; however, dAEs associated with third-generation EGFR-TKIs are lower in frequency and severity. Before therapy, health care providers should discuss the potential osimertinib-associated dAEs and encourage patients to report their dAEs. Patients should also be educated on prophylactic measures to minimize the severity of dAEs and the importance of adherence to the treatment regimen.
Um olhar valioso sobre a terra: Sudoeste do Paraná 1930-1940
Authors: Rizzarda Angélica Dalla 
Published: April 2018

O Sudoeste do Estado do Paraná foi colonizado, de forma mais intensa, em meados do século XX. Boa parte das famílias que migraram para a região foi motivada pela possibilidade de adquirir áreas de terra para o cultivo de cereais, criação de animais e principalmente pela possibilidade de subsistirem por meio do trabalho agrícola. Nesse cenário, a maior parte dos colonos é proveniente do Estado do Rio Grande do Sul, região onde se concentrou boa parte dos imigrantes italianos que vieram para o país durante o final do século XIX e início do Século XX.
As migrações a partir da década de 1930 intensificaram o processo de colonização e exploração das terras sudoestinas, como se denota das principais contribuições econômicas e culturais desses grupos, refletidas na organização do território. Em 1930, com a entrada de Getúlio Vargas ao poder iniciaram-se políticas de povoamento, dentre as quais se destaca a Marcha para o Oeste.
The importance of red cell distribution width and neutrophil-lymphocyte ratio as a new biomarker in rheumatoid arthritis
Authors: KOCA Tuba Tülay , Arslan Aydın , Çiledağ Özdemir Filiz , Berk Ejder 
Published: April 2018

Objectives: Rheumatoid arthritis
(RA) is a long-lasting autoimmune disorder that primarily affects the joints.
Various
biomarkers have been used for the prognosis and clinical follow-up. There are
few studies that have investigated whether or not neutrophil-lymphocyte ratio
(NLR) and red
cell distribution width (RDW) are good indicators of systemic
inflammation. The present study aims to explore the prognostic value of RDW and
NLR in rheumatoid arthritis (RA) as a new inflammatory marker. Methods: RA patients (n = 124) who presented to the Rheumatology outpatient clinic
in our hospital between March 2015 and May 2015 were included in this study
retrospectively. As a first group, 47 clinically active RA patients who had high
acute phase proteins were included. In the second group, 73 clinically
in-remission RA patients who had normal acute phase proteins were included.
Fifty-five healthy volunteers constituted the control group. Results: The mean RDW was found to be 15.2 ± 2.9 in the active group; 14.6 ± 2 in
the inactive group and 13.4 ± 1.4 in the control group (p &lt; 0.01). The mean NLR was found to be 3.7 ± 2.2 in the active
group; 3.7 ± 1.6 in the inactive group and 3.2 ± 0.9 in the control group (p = 0.190). There were statistically
significant differences between the RDW values of the active-period RA patients
with the control group (p &lt; 0.01).
There was statistically significant difference between RDW values of active RA
and inactive RA patients (p &lt; 0.01).
The NLR results between the RA group
and the control group (p = 0.700); the
active RA group, and the inactive RA group (p
= 0.169) were similar. There was not statistically difference between the NLR
values of active RA patients with the control group (p = 0.360). There was statistically difference between the NLR
values of inactive RA patients with the control group (p = 0.047). Conclusion: RDW was found higher in
all RA group than control, additionally was also higher in active RA group than
remission group. NLR values of remission group was higher than control.
Profile of sexual function using Female Sexual Function Index (FSFI) in post-menopausal women in Geriatric Clinic, Dr Soetomo Hospital, Surabaya
Authors: Hurrahmi Miftha , Mardiyan K Eighty , Denas A Azami , Sulistiawati Sulistiawati 
Published: April 2018

Objectives: to describe the profile of sexual function in post-menopausal women at Geriatric Clinic, Dr. Soetomo Hospital, Surabaya in May 2016 and to determine the factors of sexual dysfunction in 6 sexual domains.Materials and Methods: a descriptive study using survey to obtain data on the examined variables. Population in this study was all post-menopausal women at Geriatric Clinic of Dr. Soetomo Hospital, Surabaya, in May 2016. Data were obtained using Female Sexual Function Index (FSFI) questionnaire.Results: Total population in this study was 160 patients. The number of samples who met inclusion criteria were 90 patients, but only 37 were willing to participate. The prevalence of samples who were still active in sexual intercourse was 29.7%. Based on 6 sexual domains, the prevalence of the lack of desire was 48.6%, lack of arousal was 75.7%, lack of lubrication was 73%, lack of orgasm was 73%, lack of satisfaction was 73% and pain was 70.3%. The assessment of sexual function found that 78.4% of the samples were sexually dysfunctional.Conclusion: The high prevalence (78.4%) of sexual dysfunction in post-menopausal woman was caused by dysfunction in sexual domain.
PENGEMBANGAN INSTRUMEN BAKU KECERDASAN JAMAK ANAK USIA DINI
Authors: Jamaris Martini 
Published: April 2018

Abstract: This reasearch was done in the form of research and development. The reason underlied the selection of the reasearch method was because the purpose of the reseacrh was to develop a valid and realiable instrument which can be used to measure the multiple-intellegences of the 4-5 years old childen. The multiple-intelligences measured were consisted of eigth dimensions, there were: verbal/linguistic intelligence, logical mathematical intelligence, visual spatial intelligence, intrapersonal intelligence, interpersonal intelligence, bodily/kinesthetic intellgence, music/rythmic intelligence and naturalist intelligence. Based on the need in researching and developing, therefore, the study was conducted in two faces, as folowed : (1) the first face was literature research aiming to analyzed and synthesis concepts, principles, and theories. The result of the literature study was used formulte the construct of multiple intelligences, especially for the 4-5 years old children; (2) the second face was to define and to develop the valid and reliable multiple intelligences instrument for the 4-5 years old children.
Abstrak: Penelitian ini dilakukan dengan metode research and Development. Alasan pemilihan metode tersebut karena tujuan penelitian ini adalah mengembangkan validitas dan reliabilitas suatu instrumen yang bisa digunakan untuk mengukur kecerdasan majemuk anak usia 4-5 tahun. Kecerdasan majemuk dikur dengan delapan dimensi, yaitu: kecerdasan bahasa/verbal, kecerdasan logika matematika, kecerdasan visual, kecerdasan intrapersonal, kecerdasan interpersonal, kecerdasan gerak/kinestetik, kecerdasan musik, dan kecerdasan natural. Berdasarkan penelitian dan pengembangan, oleh karena itu, penelitian ini dilaksanakan dalam dua tahap, yaitu: (1) tahap pertama adalah penelitian literatur yang bertujuan untuk menganalisis dan mensintesis konsep, prinsip, dan teori. Hasil dari penelitian literatur digunakannnya rumus untuk mengkonstruksi kecerdasan majemuk. Khususnya anak usia 4-5 tahum, (2) tahap kedua yaitu mendefinisikan dan mengembangkan validitas dan reliabiltas instrumen kecerdasan majemuk untuk anak usia 4-5 tahun. Kata Kunci: penelitian dan pengembangan, kecerdasan majemuk, instrumen validitas dan reliabilitas, anak usia 4-5 tahun, penelitian literatur, mendefinisikan dan mengembangkan
PENGARUH KARAKTERISTIK KERJA, KOMPENSASI, DAN KEPUASAN KERJA TERHADAP KOMITMEN GURU EKONOMI PADA SEKOLAH MENENGAH ATAS (SMA) NEGERI PROVINSI BALI
Authors: Sudiarditha I Ketut R. 
Published: April 2018

In particular the aims of this research are: (1) to knew the direct effect of job characteristics toward job satisfaction of teachers. (2) to knew the direct effect on job satisfaction of teachers' compensation. (3) to knew the direct effect of job characteristics on teacher commitment. (4) to knew the direct effect of the components of teacher compensation. (5) to knew the direct effect of job satisfaction on the teachers commitment.The research was conducted at the High School (SMA) State of Bali Province which spread across nine counties and cities. The method used was survey method with causal techniques. The population in this study were all teachers who have passed the certification economics profession at High School (SMA) State of Bali province. The number of samples in the analysis suggested by Solimun Structural Equation Modeling (SEM) of 400. The findings of this study indicate that: (1) there was a direct effect of the positive characteristics of the work on job satisfaction of teachers; means that the characteristics of the corresponding work will increase the job satisfaction of a good teacher. (2) there was a direct influence on job satisfaction of teachers' compensation; synonymous with high compensation will increase the job satisfaction of good teachers. (3) there was a direct positive effect on the commitment of teachers' job characteristics; means that the characteristics of the corresponding work will increase the commitment of a good teacher. (4) there was a direct positive effect on the commitment of teachers' compensation; synonymous with high compensation will increase the commitment of a good teacher. (5) there was a direct positive effect on the commitment of teachers' job satisfaction; synonymous with high job satisfaction will increase the commitment of a good teacher.
Abstrak
Secara khusus tujuan yang ingin dicapai dalam penelitian ini adalah untuk mengetahui pengaruh langsung karakteristik kerja terhadap kepuasan kerja guru; kompensasi terhadap kepuasan kerja guru; karakteristik kerja terhadap komitmen guru; kompensasi terhadap komponen guru; dan kepuasan kerja terhadap komitmen guru. Penelitian dilakukan di Sekolah Menengah Atas (SMA) Negeri Provinsi Bali yang tersebar di sembilan kabupaten dan kota. Metode yang digunakan adalah metode survei dengan teknik kausal. Populasi dalam penelitian ini adalah seluruh guru ekonomi yang telah lulus sertifikasi profesi pada Sekolah Menengah Atas (SMA) Negeri Provinsi Bali. Temuan hasil penelitian ini menunjukkan bahwa terdapat pengaruh langsung positif karakteristik kerja terhadap kepuasan kerja guru; kompensasi terhadap kepuasan kerja guru; karakteristik kerja terhadap komitmen guru; kompensasi terhadap komitmen guru; dan kepuasan kerja terhadap komitmen guru; artinya dengan kepuasan kerja yang tinggi akan meningkatkan komitmen guru yang baik.
PERKEMBANGAN KECERDASAN LINGUISTIK DAN INTERPERSONAL ANAK USIA DINI MELALUI BERMAIN PERAN
Authors: Arsyad Lukman 
Published: April 2018

The aim of this research is to study the development of linguistic and interpersonal intelligences applying role-play method at Al-Mourky kindergarten in Gorontalo. The research was conducted qualitatively using ethnographic approach, and applying Spradley technique. Results of the research show (1) early-aged children learn through playing in accordance with their interest, needs and physical as well as mental development (2) to develop linguistic and interpersonal intelligence, the children are assigned to play the role of different people with different profession such as teacher, doctor, policeman. (3) Role play method can also enhance other multiple intelligence. The Study concludes that the role play can develop the children’s intelligence.
Abstrak

Penelitian ini bertujuan untuk mengkaji perkembangan linguistik dan kecerdasan interpersonal dengan mengaplikasikan metode bermain peran anak-anak usia dini di Al-Mourky Gorontalo. Penelitian ini dilakukan dengan menggunakan pendekatan etnografi, dan mengaplikasikan teknik Spradley. Hasil dari penelitian ini menunjukkan (1) anak usia dini belajar melalui permainan yang sesuai dengan keinginan, kebutuhan, dan fisik juga perkembangan mental mereka. (2) perkembangan linguistik dan kecerdasan interpersonal, anak-anak memainkan permainan bermain peran orang dengan profesi yang berbeda seperti guru, dokter, polisi. (3) metode bermain peran bisa juga memperkaya kecerdasan multiple. Penelitian menyimpulkan bermain peran bisa mengembangkan kecerdasan anak-anak.
Struktur Komunitas Uca Spp. Di Kawasan Hutan Mangrove, Bedul Utara, Taman Nasional Alas Purwo, Jawa Timur
Authors: Rizal Muhamad , Febriyanti Dewi , Sabila Husna ` , Damarwati Wahyu , Isfaeni Hanum 
Published: April 2018

Abstract

The study aims were to determine the community structure of Uca sp.and its environmental factor at the segara anakan north Bedul Alas purwo national park. Research conducted when the lowest tide began on april 24th,2017. At research station, 30 sampling points was determined by purposive sampling method. Samples ware taken by making 1x1 square, space 5m between each square and observed with the space 2m between square and observer and after ten minutes then recorded all the species belonging to each plot. Environment parameters measured to determine the diference of environmental factor to structure community of Uca crabs. Samples of crab preserved with formaldehida 4% and collected in tha jar. Eight species were found in segara anakan north bedul is Uca rosea, Uca perplexa, Uca capricornis, Uca bellator, Uca tetragonon, Uca crassipes, Uca rapax, Uca lactea.

Abstrak
Penelitian ini bertujuan untuk mengetahui struktur komunitas dari Uca sp. di kawasan hutan mangrove serta faktor lingkungan yang mempengaruhinya. Penelitian dilakukan pada saat air surut terendah. Penelitian ini dilakukan pada 24 April 2017. Metode yang dilakukan ialah dengan purposive sampling dan dengan menggunakan belt transek. Penelitian dilakukan dengan membuat plot berukuran 2 m x 2 m sebanyak 30 plot dan dengan jarak antar plot ialah 5 m. Penelitian dilakukan dengan pengamatan dari jarak 2 m dan setelah 10 menit kemudian di catat semua spesies yang termasuk ke dalam tiap plot. Dilakukan pengukuran parameter lingkungan untuk mengetahui perbedaan faktor lingkungan terhadap struktur komunitas kepiting Uca. Spesies kepiting yang telah tercatat diambil individunya untuk dijadikan sampel dan dilakukan identifikasi kemudian diawetkan di dalam botol selai dengan menggunakan formalin 4%. Sebanyak 8 jenis kepiting Uca yang ditemukan di hutan mangrove kawasan Bedul, yaitu Uca rosea, Uca perplexa, Uca capricornis, Uca bellator, Uca tetragonon, Uca crassipes, Uca rapax, Uca lactea.
KABA: CERITA KLASIK YANG MENGANDUNG KEKELIRUAN DENGAN TOLOK UKUR ABS-SBK
Authors: Zahari Musril 
Published: April 2018

This study discusses kaba, the oral classic story in Minangkabau society that has been written as the book. The kaba is usually told by the story tellers accompanied by his music instruments. Many kabas exist in the Minangkabau community, but in this study I only discuss two kabas (1) Magek Manandin (2) Anggun Nan Tongga. Based on both kabas, I found that the gambling forbidden by Islam as if allowable. Within Anggun Nan Tongga, there are many discourses which are syirik (do worship other than Allah) that is slammed by Islam. These discourses should have not existed because they oppose to the philosophy of life in Minangkabau: custom/tradition founded upon Islamic law, Islamic law is founded upon the Qur'an, Islamic law dictates customs/traditions. This philosophy as the agreement among Minangkabau people is forbidden to change forever. Unfortunately, in these two kabas, the discourses about the gambling and kesyirikan are regarded as if the truth even though so many verses in the Alquran explain about these deviations.
Abstrak
Penelitian ini mendiskusikan tentang kaba, cerita turun temurun suku Minangkabau dituliskan ke dalam sebuah buku. Kaba biasanya diceritakan oleh seseorang dengan iringan musik. Banyak Kabas terdapat dalam suku Minangkabau. Tapi dalam penelitian ini hanya mendiskusikan dua Abas (1) Magek Manandin, (2) Anggun Nan Tongga. Berasal dari kedua kaba tersebut, saya menemukan larangan judi oleh Islam yang seolah-seolah diizinkan. Dalam Anggun Nan Tongga, terdapat banyak ceramah yang mana sirik (menyembah sesuatu selain Allah) adalah menghancurkan islam. Ceramah ini tidak seharusnya ada karena mereka menentang filosofi kehidupan suku Minangkabau: baju/ tradisi yang ditemukan berdasarkan hukum islam, hukum islam ditemukan berdasarkan AlQur’an. Hukum islam diktat tradisi. Filosofi ini sebagai persetujuan orang-orang Minangkabau yang melarang perubahan selamanya. Sayangnya, dalam dua Kaba ini, ceramah tentang perjudian dan kesyirikan dianggap seolah-olah suatu kebenaran. Walaupun, banyak versi Alqur’an yang menjambarkan tentang penyimpangan ini.
Managing Social Impacts of Labour Influx: Lessons Learned from a World Bank Global Portfolio Review
Authors: Wagner Jay , Dowse Susan , Jones Murray , Orenstein Marla , Owen Dan 
Published: April 2018

Abstract
Labor influx is not a new phenomenon and can occur in the context of any major project, including in oil and gas, mining and infrastructure developments. The large-scale and often remote and trans-boundary nature of oil and gas projects can make such undertakings particularly vulnerable to such dynamics. A key driver of socio-economic change in any project context can be rapid population growth or influx in response to project labor demand, or perceptions of direct or indirect economic opportunity associated with the project.
Whereas labor influx can have positive effects (e.g., increased opportunities for local businesses, increased human capital), more often than not labor influxresults in or contributes to adverse social, economic, and environmental impacts. If not planned for and effectivelymanaged, labor influx can lead to human welfare risks, including gender-based violence and trauma and negatively affect public infrastructure, housing, natural resource management and social dynamics in the project area and region. These impacts, whichoften long outlast the project and investment cycle, canrepresenta significant risk for oil and gasprojects andlead tocommunity anger and social conflict, reputational impacts, investor concerns, cost overruns, delays, and in extreme cases can put at risk the License to Operate.
This paper summarizes the results of a recent global portfolio review focused on labor influx and social impacts commissioned by World Bank (WB). The study was carried out in 2017 as part of a series of actions set in motion by serious allegations of social impact related to a transport project in Uganda, which resulted in the ultimate cancellation of the investment by the WB. While drawing on research into infrastructure projects the paperdiscusseskey observations and lessonsrelevant to the oil and gas industry, and provides recommendations for project planners and managers faced with the potential for labor influx. It concludes that influx is a strategic but often overlooked aspect of project risk management, and outlineskey mitigation measures that should be in every project's social risk management toolkit.
A Comprehensive Model for Single Ring Infiltration II: Estimating Field‐Saturated Hydraulic Conductivity
Authors: Stewart Ryan D. , Abou Najm Majdi R. 
Published: April 2018

Core Ideas
Four approaches were tested to estimate Kfs from single ring infiltration data.
Highest accuracy occurred when capillary length was appropriately constrained.
Kfs estimates improved if capillary length was overestimated vs. underestimated.
Assuming a universal capillary length can also be useful for determining Kfs.
Kfs can be accurately estimated using both early‐time and steady‐state data.
In this study, we explored four approaches to infer field‐saturated hydraulic conductivity (Kfs) from both early‐time and steady‐state infiltration measurements using an explicit expression for three‐dimensional flow. All approaches required an estimate of the soil capillary length, λ. Approach 1 estimated Kfs via optimization, in which all other infiltration parameters (9 in total) were known. The remaining approaches constrained λ through different interpretations of coefficients generated by linear regression between infiltration and time. Approach 2 utilized these coefficients plus estimated soil water content to simultaneously quantify both λ and Kfs. Approach 3 used an analytical expression in which λ was estimated based on water retention/unsaturated hydraulic conductivity parameters, while Approach 4 adopted a universal λ value of 15 cm. The accuracy of these four approaches were tested using numerical and laboratory infiltration data. Approach 1 had the highest accuracy but also required the most auxiliary data, making it most suitable for laboratory and numerical experiments. Approach 2 was the least consistent, providing negative estimates for λ and Kfs under certain conditions. Approach 3 also gave accurate predictions of Kfs, but may be inaccurate in instances where the water retention model parameters are uncertain or do not describe soil hydraulic behaviors well. Approach 4 provided reasonable estimates of Kfs (within a factor of three from the actual value in most cases), while not requiring additional observational data. The optimal approach for interpreting Kfs will thus vary depending on the type and quality of available auxiliary data.