bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serial changes in patient-reported outcome measures and satisfaction rate during long-term follow-up after total knee arthroplasty: a systematic review and meta-analysis
Authors: Park Jisu , Chang Moon Jong , Kim Tae Woo , D’Lima Darryl D. , Kim Hyunkwon , Han Hyuk-Soo 
Published: December 2024

Abstract
Purpose
This study aimed to investigate the sequential changes in patient-reported outcome measures (PROMs) and the satisfaction rate during long-term follow-up after total knee arthroplasty (TKA).

Methods
Studies published until December 2023 were searched in MEDLINE, EMBASE, SCOPUS and Cochrane Library. The inclusion criteria were TKA as the primary procedure, a final post-operative follow-up period of at least seven years and reporting of PROMs data. The exclusion criteria were studies not reporting serial data of the same patient cohort, studies without mid-term data, comparative studies and reviews, comments or practice guidelines. Heterogeneity was assessed with the I2 and tau2 statistics. The quality of each study was evaluated using the methodological index for non-randomized studies (MINORS) criteria. The follow-up periods were divided into short-term, mid-term and long-term. Data were synthesised by narrative reviews and random-effects meta-analysis using standardised mean difference.

Results
Among the 13 studies included in the review, six were included in the meta-analysis. The overall PROMs were maintained until the mid-term (0.14; 95% CI [confidence interval], −0.05 to 0.34; I2 = 96%; tau2 = 0.10; P = 0.16), but declined in the long-term (−0.23; 95% CI −0.34 to −0.13; I2 = 88%; tau2 = 0.04; P < 0.0001). According to the subgroup analysis, pain improved from the short-term to mid-term (0.21; 95% CI 0.14 to 0.29; I2 = 0%; tau2 = 0). Subscales including function (−0.28; 95% CI −0.52 to −0.03; I2 = 94%; tau2 = 0.09) and objective measure (−0.23; 95% CI −0.31 to −0.15; I2 = 62%; tau2 = 0.01) declined from the mid-term to long-term. The patient satisfaction rate remained consistent throughout the study period.

Conclusions
The overall PROMs after TKA were maintained, with improvement observed in the pain subscale until the mid-term follow-up. However, in the long-term, overall PROMs, including function and objective measure, declined compared with those in the mid-term. Despite the decline in the physical aspects of PROMs over the long-term follow-up period, the patient satisfaction rate remained consistently high throughout the study period. Providing this information to patient pre-operatively may assist in establishing realistic expectations.
Trial Registration This research was registered at PROSPERO (registration number: CRD42024578579).
Correlation between Q angle and hip abductor muscle strength in patients with knee osteoarthritis
Authors: Mandal Saikat , Saha Sourov 
Published: December 2024

Abstract
Background
The Q angle has a major impact on the lower limb’s static alignment in the frontal plane; also, the lever-arm distance between the hip and knee joint centers also changes the hip abductor muscles’ ability to produce torque. An association between Q angle and hip muscle strength has been investigated in different population. However, the relationship between Q angle and hip abductor muscle strength in early knee osteoarthritis has not been investigated. Therefore, the objective of the study was to investigate the correlation between Q angle and hip abductor muscle strength in patients with initial stage of knee osteoarthritis (OA).

Study design
This is a correlation study.

Methodology
Fifty-four involved OA knee among 32 patients (26 female and 6 male), with mean age of 49.38 ± 5.68 years, were included in the study. The Q angle was measured by universal goniometer, and the hip abductor muscle strength was measured by a hydraulic handheld dynamometer.

Results
Spearman’s correlation coefficient test showed that Q angle is significantly (weak negative) correlated (r =  − 0.31; p < 0.05) with hip abductor muscle strength, in patients with knee osteoarthritis.

Conclusion
There is a correlation between Q angle and hip abductor muscle strength in patients with knee OA. So, with the decrease in hip abductor, muscle strength may lead to increase in Q angle, which may be a factor responsible for early-stage degenerative changes in knee OA.
Αξιολόγηση της εισαγωγικής φάσης μιας διδακτικής μαθησιακής ακολουθίας σε θέματα σωματιδιακής φυσικής
Authors: Κλαυδιανού Στυλιανή , Μολοχίδης Αναστάσιος 
Published: December 2024

Η σωματιδιακή φυσική αποτελεί γνωστικό περιεχόμενο που ενδιαφέρει τους μαθητές, μιας και είναι πειραματικά ενεργή και επίκαιρη στην επιστημονική κοινότητα. Το ελληνικό πρόγραμμα σπουδών εμπεριέχει αποσπασματικά έννοιες σωματιδιακής φυσικής χωρίς να υπάρχει ωστόσο ειδικό κεφάλαιο. Η παρούσα εργασία παρουσιάζει το εισαγωγικό στάδιο του σχεδιασμού μιας διδακτικής μαθησιακής ακολουθίας (ΔΜΑ) σε θέματα σωματιδιακής φυσικής: διερευνήθηκαν εναλλακτικές αντιλήψεις των μαθητών, όπως αυτές αναφέρονται στη βιβλιογραφία, αναπτύχθηκαν δραστηριότητες που διαχειρίζονται το εννοιολογικό περιεχόμενο και εισάγουν τον πειραματισμό με στόχο να βοηθηθούν οι μαθητές να διαχειριστούν τις δυσκολίες αυτές.
STEM Digitalis: Ανάπτυξη ψηφιακών μαθησιακών αντικειμένων για STEM εκπαίδευση μελλοντικών εκπαιδευτικών
Authors: Καπελώνης Νικόλαος , Μποτζάκη Ελένη , Μπιτσάκη Χαρά , Μεταξάς Ιωάννης , Ζουρμπάκης Αλκίνοος-Ιωάννης , Χαλκιαδάκης Κωνσταντίνος , Κοκολάκη Αθανασία , Μιχαηλίδη Αιμιλία , Σταύρου Δημήτρης 
Published: December 2024

Η παρούσα εργασία περιγράφει το πρόγραμμα “STEM DIGITALIS” που αποτελεί μια κοινοπραξία μεταξύ πέντε ακαδημαϊκών ιδρυμάτων στο πλαίσιο του ευρωπαϊκού σχεδίου Erasmus+ για ανταλλαγή καλών πρακτικών στην Γ/θμια Εκπαίδευση. Σκοπός του προγράμματος είναι η ανάπτυξη μικτών και εξ αποστάσεως περιβαλλόντων μάθησης για εκπαίδευση μελλοντικών εκπαιδευτικών Α/θμιας και Β/θμιας εκπαίδευσης σε προηγμένα STEM αντικείμενα όπως η κλιματική αλλαγή, οι ανανεώσιμες πηγές ενέργειας κ.λπ.. Ειδικότερα, διερευνήθηκαν τα κριτήρια επιλογής ψηφιακών εργαλείων για ψηφιοποίηση STEM δραστηριοτήτων, καθώς και οι πιθανές δυνατότητες και περιορισμοί των ψηφιοποιημένων STEM δραστηριοτήτων που αναπτύχθηκαν.
Διδασκαλία και κατανόηση του οικολογικού αποτυπώματος από μαθητές/ τριες Γυμνασίου
Authors: Μελέτη Θεοδώρα , Γαλάνης Νικόλαος , Αμπράζης Αλέξανδρος , Παπαδοπούλου Πηνελόπη , Πανάρας Γεώργιος , Μαλανδράκης Γεώργιος 
Published: December 2024

Σκοπός της εργασίας είναι η αξιολόγηση του μαθησιακού αντίκτυπου, δηλαδή της βελτίωσης στην κατανόηση της έννοιας του Οικολογικού Αποτυπώματος (ΟΑ) από μαθητές/τριες Γυμνασίου, μετά από σχετική διδασκαλία. Η διδακτική παρέμβαση (ΔΠ) είχε διάρκεια 8 διδακτικές ώρες και εφαρμόστηκε σε 39 μαθητές/τριες Γυμνασίου της Δυτικής Μακεδονίας. Εργαλείο αξιολόγησης της μάθησης και συλλογής των δεδομένων αποτέλεσε ένα ερωτηματολόγιο 24 ερωτήσεων, οργανωμένων σε έξι (6) άξονες, οι οποίοι αντιστοιχούσαν σε αυτούς του ΟΑ (διατροφή, υποδομές/κατοικίες, κατανάλωση ενέργειας, αγαθά και υπηρεσίες, απορρίμματα και μετακινήσεις), το οποίο επιδόθηκε στους μαθητές/τριες πριν και μετά τη ΔΠ. Τα αποτελέσματα κατέδειξαν ότι στους 4 από τους 6 άξονες, σημειώθηκε βελτίωση ως προς την κατανόηση της έννοιας του ΟΑ, με στατιστικά σημαντική διαφορά να παρατηρείται όμως μόνο στον άξονα των απορριμμάτων.
Fair Collaborative Learning (FairCL): A Method to Improve Fairness amid Personalization
Authors: Lin Feng , Zhao Chaoyue , Qian Xiaoning , Vehik Kendra , Huang Shuai 
Published: December 2024

Model personalization has attracted widespread attention in recent years. In an ideal situation, if individuals’ data are sufficient, model personalization can be realized by building models separately for different individuals using their own data. But, in reality, individuals often have data sets of varying sizes and qualities. To overcome this disparity, collaborative learning has emerged as a generic strategy for model personalization, but there is no mechanism to ensure fairness in this framework. In this paper, we develop fair collaborative learning (FairCL) that could potentially integrate a variety of fairness concepts. We further focus on two specific fairness metrics, the bounded individual loss and individual fairness, and develop a self-adaptive algorithm for FairCL and conduct both simulated and real-world case studies. Our study reveals that model fairness and accuracy could be improved simultaneously in the context of model personalization. History: Bianca Maria Colosimo served as the senior editor for this article. Funding: This work was supported by the Breakthrough T1D Award [Grant 2-SRA-2022-1259-S-B]. Data Ethics & Reproducibility Note: The code capsule is available on Code Ocean at https://codeocean.com/capsule/1331847/tree/v1 and in the e-Companion to this article (available at https://doi.org/10.1287/ijds.2024.0029 ). The real-world data, including the transportation demand management and surgical site infection data sets, are proprietary and not publicly available. Other results are available at https://github.com/ryanlif/FairCL .
A Semidefinite Programming-Based Branch-and-Cut Algorithm for Biclustering
Authors: Sudoso Antonio M. 
Published: December 2024

Biclustering, also called co-clustering, block clustering, or two-way clustering, involves the simultaneous clustering of both the rows and the columns of a data matrix into distinct groups such that the rows and columns within a group display similar patterns. As a model problem for biclustering, we consider the k-densest disjoint biclique problem, whose goal is to identify k disjoint complete bipartite subgraphs (called bicliques) of a given weighted complete bipartite graph such that the sum of their densities is maximized. To address this problem, we present a tailored branch-and-cut algorithm. For the upper-bound routine, we consider a semidefinite programming relaxation and propose valid inequalities to strengthen the bound. We solve this relaxation in a cutting-plane fashion using a first-order method. For the lower bound, we design a maximum weight matching rounding procedure that exploits the solution of the relaxation solved at each node. Computational results on both synthetic and real-world instances show that the proposed algorithm can solve instances approximately 20 times larger than those handled by general-purpose solvers. History: Accepted by Antonio Frangioni, Area Editor for Design & Analysis of Algorithms–Continuous. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2024.0683 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2024.0683 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Toxic epidermal necrolysis: management strategies in burns units
Authors: Escuredo Iker Miguel , Weisz Laura Cabañas , Manau Javier Vásquez , Soto Juan Bautista Ayestarán , García Jesus Gardeazabal 
Published: December 2024

Objective: The most common severe exfoliative condition is toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, for which patients may sometimes require admission to hospital burns units. This study analyses the experience of the authors and results in this condition at the Cruces University Hospital in Bilbao, Spain. Method: Over the last 22 years, the authors carried out a retrospective analytical observational study of TEN cases at the hospital and analysed risk factors including age, associated comorbidities, percentage of body surface area affected, positive bacterial culture, and treatment strategies used to assess their potential influence on prognosis. Results: The results indicated an association between mortality and age (ρ (rho)=0.60, 95% CI [0.29, 0.79], p<0,001), ocular (ρ=0.58, 95% CI [0.28, 0.78], p<0.001), oropharyngeal (ρ=0.64, 95% CI [0.36, 0.81], p<0.001), genitourinary (ρ=0.58 CI [0.28, 0.78], p<0.001) respiratory mucosa involvement (ρ=0.53, 95 % CI [0.28, 0.78], p<0.001) and bacteraemia (ρ=0.44, 95% CI [0.17, 0.64], p=0.020). Bacteraemia also showed a higher incidence in elderly patients (ρ=0.4, 95% CI [0.03, 0.67], p=0.033) and in those with a higher Score for Toxic Epidermal Necrolysis at admission (ρ=0.51, CI [0.17, 0.74], p=0.006). A reduction in mortality was found in patients who received systemic treatment; cyclosporine, etanercept or a combination of both (ρ=-0.44, Cl [-0.70, -0.09], p=0.018). Conclusion: TEN is a rare but serious exfoliative condition. Traditionally, management of denuded skin was seen as the main prognostic factor; yet, systemic damage, especially to the respiratory mucosa, significantly increases mortality risk. While life support is crucial and recovery is possible, preventing long-term sequelae relies on effective care protocols. Current treatments may offer benefits, though their efficacy remains unclear. Clinicians in burns units should develop standardised protocols and collaborate on long-term studies to enhance patient care.
Early results of an orthoplastic multidisciplinary approach to diabetic foot ulcer soft tissue reconstruction
Authors: Thng Coeway Boulder , Wong Keng Lin , Wong Allen Wei-Jiat , Chew Khong Yik , Leow Kimberley , Alvis Leon Timothy Charles , Leong Sum , Irani Farah Gillan , Png Wenxian , Cher Eric Wei Liang , Ma Zhongzheng , Moksin Mardiana Binte , Wong Merng Koon , Tan Pearlie Woon Woon , Kok Yee Onn , Feng Jiajun 
Published: December 2024

Objective: Diabetic foot ulcer (DFU) is a common complication in patients with diabetes. With current treatment, only two-thirds of patients heal, with a median duration of 3–6 months. Hard-to-heal DFUs are a major source of morbidity and mortality. Improving wound healing via soft tissue reconstruction may be the key to improving clinical outcomes. Thus, the Diabetic Limb Salvage (DLS) service in Sengkang General Hospital, Singapore, was established to provide patients with a streamlined, one-stop, comprehensive service dedicated to DFU soft tissue reconstruction. The reconstruction was carried out using secondary closure, skin grafting, local flaps or free flaps, depending on the severity of the wound and patient suitability. This study aims to audit the early outcomes of the DLS service. Method: Patients with DFUs treated by the DLS service were compared with patients with DFUs treated prior to the launch of the DLS service (control). Outcomes including major and minor amputation rates, wound healing rate, mortality and DFU recurrence rates were analysed statistically. Results: A total of 103 patients took part in the study (50 in the DLS service cohort and 50 in the control cohort). There was no significant difference in demographics, comorbidities and wound profiles between the two cohorts. All (100%) patients in the DLS service cohort received soft tissue reconstruction versus only 13% in the control group. The DLS service cohort had a significantly higher healing rate (96% versus 68%, respectively), shorter healing duration (77±30 days versus 111±43 days, respectively), reduced major amputation rate (0% versus 9%, respectively), and reduced recurrence rate (6% versus 25%, respectively) compared with the control cohort within the one-year follow-up. Conclusion: The findings of this study showed that an orthoplastic multidisciplinary approach focused on DFU soft tissue reconstruction improved wound healing rates, shortened healing duration and, as a result, lowered amputation rates and reduced recurrence.
Factors associated with post-pandemic acceptance of COVID-19 vaccines among students in three Nigerian universities
Authors: Mosanya Adaobi Uchenna , Ezekwelu Adaeze , Ugochukwu Ezinwanne Jane , Ukoha-Kalu Blessing Onyinye 
Published: December 2024

Background
The COVID-19 pandemic impacted the world in every aspect. Higher institutions were greatly affected because the outbreak disrupted the teaching and learning structure. Vaccines decrease the rate of infection and transmission of the virus, but the presence of some myths has led to hesitancy towards the vaccine.

Objective
The purpose of the survey was to assess the knowledge, perception, and acceptance of the COVID-19 vaccine among undergraduate students in Enugu State, Nigeria.

Methods
This was a cross-sectional study carried out among undergraduate students at the University of Nigeria Nsukka (UNN), the Institute of Management and Technology (IMT), and Enugu State University of Technology Enugu state (ESUT), Nigeria between March and November 2023. These institutions were chosen based on their large student populations, diverse academic offerings, and significant geographical coverage within the state. Data collection was done using a 26-item validated self-administered questionnaire. Statistical Product and Service Solutions (SPSS) version 25 with appropriate descriptive (frequency and percentage) and inferential statistics (Chi-square) were used to analyze the data.

Results
1,143 completed questionnaires were obtained. The modal age range was 18–24 years accounting for 814 (71.2%) of the participants. A total of 577 (50.5%) participants demonstrated a good level of knowledge while 685 (59.9%) showed a positive perception of the COVID-19 vaccine. Gender (p = 0.010) and institution (p < 0.001) were associated with their perception of the COVID-19 vaccine. In addition, knowledge and perception of the COVID-19 vaccine were significantly associated with its acceptance at p = 0.038 and < 0.001, respectively.

Conclusion
This study reveals that COVID-19 vaccine acceptance among university students in Enugu State, Nigeria, remains low despite moderate knowledge and generally positive attitudes, with perceptions playing a more significant role than knowledge. The findings highlight the need for educational interventions that not only provide accurate information but also actively address misconceptions. To improve vaccine uptake, public health campaigns should focus on shifting perceptions through culturally sensitive, institution-specific strategies.
Coronary embolism in left-sided infective endocarditis. A retrospective analysis from a high-volume surgical centre and review of the literature
Authors: Mazzotta Ruggero , Orlandi Matteo , Scheggi Valentina , Marchionni Niccolò , Stefàno Pierluigi 
Published: December 2024

Background
Septic embolization is a common and potentially life-threatening complication of infective endocarditis (IE), with a prevalence of 22–50%. While acute coronary syndrome secondary to septic embolism is rare, it poses significant risks.

Aims
This study examines coronary embolism (CE) in left-sided IE, describing clinical characteristics and outcomes.

Methods
We retrospectively analysed 649 patients with non-device-related left-sided IE treated between January 2013 and December 2023 in a high-volume surgical centre. CE was diagnosed via ECG, clinical and laboratory signs of acute coronary syndrome, and confirmed by coronary angiography or magnetic resonance imaging. All patients were treated according to current European Society of Cardiology guidelines. A structured follow-up was performed.

Results
Among patients included in the study, surgery was performed in 514 (79%) patients. Median follow-up duration was 4.7 years. CE occurred in 8 (1.2%) patients, and 6 (80%) of them were treated surgically. We found no significant differences in overall mortality rate between patients with or without CE (p = 0.65). Finally, cerebral embolism was significantly more frequent in patients with than without CE (75% vs 25%, p = 0.006, post-hoc power 87.8%).

Conclusion
CE is a rare but severe complication of IE, significantly associated with cerebral embolism. Early recognition and treatment are crucial to improve patient outcomes. Multicentre studies with larger patient populations are needed to further elucidate risk factors and enhance prognosis for CE in IE patients.
Pengaruh Biopestisida Kulit Bawang Merah (Allium cepa) Terhadap Laju Respirasi Jangkrik (Gryllus bimaculatus)
Authors: Isdadiyanto Sri , Nursabrina Azra Batrisyia , Sunarno Sunarno 
Published: December 2024

Kulit bawang merah mengandung senyawa asetogenin berupa skuamosin yang berpotensi sebagai bahan biopestisida untuk pengendalian hama jangkrik pada tanaman pertanian. Penelitian ini bertujuan untuk menganalisis pengaruh biopestisida dari ekstrak kulit bawang merah terhadap bobot badan dan laju respirasi, serta memperoleh dosis optimum biopestisida terhadap mortalitas jangkrik. Penelitian ini menggunakan desain rancangan acak lengkap faktor tunggal yang terdiri atas 5 ulangan dengan 5 perlakuan yaitu 0% (kontrol), 25%, 50%, 75%, dan 100%. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang nyata antara kelompok perlakuan pemberian biopestisida dengan kelompok kontrol pada bobot badan dan laju respirasi jangkrik. Hasil uji regresi antara dosis biopestisida dengan penurunan bobot badan menunjukkan hubungan yang kuat sebesar 54,3% dan pada peningkatan laju respirasi menunjukkan hubungan yang sangat kuat sebesar 75,2%. Dosis biopestisida optimum pada mortalitas jangkrik sebesar 100%. Kesimpulan penelitian ini adalah senyawa asetogenin skuamosin dalam biopestisida ekstrak kulit bawang merah dapat menaikkan laju respirasi jangkrik. Red onion peels contain the acetogenin compound in the form of squamosin which has the potential to be used as a biopesticide to control cricket pests on crops. This research aims to analyze the effect of biopesticide from red onion peels extract on body weight and respiration rate, as well as to obtain the optimum dose of biopesticide on cricket mortality. This study used a single factor completely randomized design consisting of 5 replications with 5 treatments, namely 0% (control), 25%, 50%, 75% and 100%. The results of the study showed that there were significant differences between the treatment group given biopesticide and the control group in body weight and respiration rate of crickets. The results of the regression test between biopesticide dose and reduction in body weight showed a strong relationship of 54.3% and an increase in respiration rate showed a very strong relationship of 75.2%. The optimum biopesticide dose for cricket mortality is 100%. This research concludes that the compound acetogenin squamosin in the biopesticide extract of shallot skin can increase the respiration rate of crickets.