bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smoking Status Among Patients With Newly Diagnosed Lung Cancer in Taiwan
Authors: YANG Chia-Chen , LIU Chien-Ying , WANG Kwua-Yun , WEN Fur-Hsing , LEE Yu-Chin , CHEN Mei-Ling 
Published: November 2018

ABSTRACT

Background
Continued smoking after receiving a diagnosis of cancer seriously affects disease prognosis and survival. The prevalence and risk factors of continued smoking among patients with newly diagnosed lung cancer are unknown in Taiwan.

Purpose
The aims of this study were to assess the smoking status of patients with newly diagnosed lung cancer and to identify the characteristics that are associated with different smoking statuses.

Methods
Baseline data of a longitudinal study on smoking behaviors after lung cancer diagnosis were analyzed in this study. Patients were consecutively recruited from three medical centers in northern Taiwan. A structured questionnaire and medical chart reviews were used to collect data. Multinomial logistic regression analysis was used to examine the factors associated with continuing to smoke after being diagnosed with lung cancer.

Results
Among the 406 patients with newly diagnosed lung cancer who were recruited, 47.0% were never-smokers and 53.0% were ever-smokers. Among the second group, 38% were former smokers, 18% were recent quitters, and 44% were current smokers. Compared with former smokers, current smokers were more likely to be younger (OR = 1.05), to not exercise regularly (OR = 2.74), to currently live with smokers (OR = 2.48), and to have lower self-efficacy for refusing to smoke (OR = 0.95). Compared with recent quitters, current smokers were more likely to have lower self-efficacy for refusing to smoke.

Conclusions/Implications for Practice
A significant proportion of ever-smoker lung cancer patients in Taiwan will continue to smoke after receiving their diagnosis. Variables known to modify the risk factors associated with continued smoking such as regular exercise and better refusal self-efficacy should be considered and incorporated into future smoking cessation programs for patients with lung cancer.
Gastrointestinal recall questionnaires compare poorly with prospective patient diaries for gastrointestinal symptoms: data from population and primary health centre samples
Authors: Jones Michael P. , Walter Susanna , Faresjö Åshild , Grodzinsky Ewa , Kjellström Lars , Viktorsson Lisa , Talley Nicholas J. , Agreus Lars , Andreasson Anna 
Published: November 2018

Background
Clinical understanding of gastrointestinal symptoms is commonly based on patient reports of symptom experience. For diagnosis and treatment choices to be appropriate, symptom reports need to be accurate. We examined the agreement between questionnaire recall and prospective diary enumeration of symptoms relevant to the irritable bowel syndrome.

Patients and methods
Data are reported from a randomly selected general population sample (n=238) and also a primary healthcare centre (PHC) sample (n=503, 10 PHCs). All the patients completed the questionnaires, which included Rome III-qualifying irritable bowel syndrome items and a stool and symptom diary over either 7 or 14 days. Agreement between retrospective questionnaire reports and prospective diaries was evaluated.

Results
Concordance between questionnaires and diaries was highest for the simple construct of the occurrence of abdominal pain, although after adjusting for possible chance, agreement was only moderate in the general population sample. More complex constructs, such as pain relieved by defecation, yielded poorer concordance. In general, concordance was stronger among PHC respondents than in the general population sample.

Conclusion
Concordance between questionnaires and diaries was generally poor and related to the complexity of the symptom construct and the type of respondent. The information used to classify individuals based on patient self-report may be unreliable, and therefore, more effort is needed to develop data collection instruments.
Can Mobile Devices Be Used as an Active Learning Strategy? Student Perceptions of Mobile Device Use in a Nursing Course
Authors: Gallegos Cara , Gehrke Pamela , Nakashima Hannah 
Published: November 2018

Background
It can be challenging to engage prelicensure nursing students in theoretical, nonclinical courses.

Purpose
The purpose of this study was to describe students' experiences with various teaching strategies and describe student perceptions of engagement and learning using a mobile device.

Methods
The study had a mixed-methods design, which included an online survey and oral interviews to elicit student perceptions of engagement and learning using a mobile device.

Results
Students, on average, reported high levels of perceived learning and moderate levels of perceived engagement. Analysis of the qualitative transcripts revealed 2 major themes clustered around learner practices and instructor/course practices.

Conclusions
Overall, students reported that using the mobile devices was a positive experience. Students benefited from thoughtful, intentional mobile device use that engaged them with course ideas, limited off-task distractions, and improved collaborative experiences with peers and the instructor.
Use of Script Concordance Activity With the Think-Aloud Approach to Foster Clinical Reasoning in Nursing Students
Authors: Tedesco-Schneck Mary 
Published: November 2018

Background
Script concordance testing and the think-aloud (TA) approach uses clinical scenarios to evaluate clinical reasoning (CR).

Problem
Teaching strategies to both facilitate and evaluate CR are lacking. Adaptation of script concordance testing and the TA approach may be a useful teaching/learning strategy for CR.

Approach
Script concordance activity with the TA approach (SCA-TA method) was created and implemented in a nursing course to facilitate and evaluate CR.

Evaluation
Survey data provided valuable information of students' perception about the SCA-TA method as a teaching strategy.

Conclusions
The SCA-TA method holds promise to foster CR. Ongoing research to predict progression of CR is needed.
The Meaning of Grades
Authors: Poorman Susan G. , Mastorovich Melissa L. 
Published: November 2018

Background
Although the literature is replete with information about grades, there is a lack of empirical evidence about the meaning of grades to nursing students.

Purpose
This study sought to understand the meaning of grades for nursing students at all educational levels.

Method
Using Heideggerian hermeneutic phenomenology, 46 nursing students from 14 schools were asked to tell about a time that stood out to them when they were graded. They then reflected on their story and described what this experience meant to them.

Results
Data analysis revealed several themes. The main theme was “needing an A.” It was discussed by students at every level of nursing education.

Conclusions
Students not only needed to get an A, but also they needed to get an A in every course they took, causing stress and disappointment when they were unable to achieve these grades. It seemed that what they were learning was not as important as the grade they received.
Point-of-Care Ultrasound Facilitates Bedside Diagnosis of Appendicitis With an Appendicolith in a Pediatric Patient
Authors: Pade Kathryn H. 
Published: November 2018

Abstract
A previously healthy 5-year-old boy presented to the emergency department with a history of tactile fevers, cough, congestion, decreased appetite, and abdominal pain. He had diffuse abdominal pain on examination and pain with ambulation. Emergency point-of-care ultrasound was used to diagnose appendicitis with an appendicolith. The diagnosis was confirmed by a radiology-performed ultrasound, and he was taken to the operating room for an appendectomy.
The Neuroscience of Pain: Biobehavioral, Developmental, and Psychosocial Mechanisms Relevant to Intervention Targets
Authors: Atlas Lauren Y. , al'Absi Mustafa 
Published: November 2018

ABSTRACT
Chronic pain is a major problem in clinical medicine and public health, affecting approximately one in five adults, and is associated with significant societal and familial burden. Early-life adversities, psychological, and biobehavioral factors are associated with an elevated risk of the subsequent development of chronic pain. In this special issue of Psychosomatic Medicine, articles address the neuroscientific, psychological, and biobehavioral processes involved in acute and chronic pain. We focus on the following themes that emerged in this special issue: (a) risk factors and early adversity as related to chronic pain; (b) the role of expectations in shaping pain perception; and (c) mechanisms of interventions targeting pain modulation. This article concludes by outlining important new targets for research, including the neurobiology of pain, important methodological challenges, and targets for personalized pain interventions.
The Impact of Different Magnetic Resonance Imaging Equipment and Scanning Parameters on Signal Intensity Ratio Measurements in Phantoms and Healthy Volunteers
Authors: Young Laura K. , Gandy Stephen J. , Priba Lukasz , Matthew Shona Z. , Graeme Houston J. 
Published: November 2018

Objectives
The aim of this study was to examine the variation in signal intensity ratio (SIR) values in Eurospin gel phantoms and healthy volunteer (HV) brain images in response to different magnetic resonance imaging hardware and software settings.

Materials and Methods
Gel phantoms with T1 relaxation times similar to the dentate nucleus (DN), pons (P), globus palladus (GP), and thalamus (Th) were scanned using a T1-weighted 2-dimensional spin-echo sequence on 2 magnetic resonance imaging scanners (3 T and 1.5 T). Imaging was performed by sequentially altering selected magnetic resonance (MR) parameters relative to a default pulse sequence, and the protocol was implemented repeatedly over 3 months. The experiment was also repeated on a cohort of 15 young HVs. Calculations of DN/P and GP/Th SIR values were derived for the images of the gels (GelDN/P and GelGP/Th) and the HVs (HVDN/P and HVGP/Th).

Results
For the default sequence, the mean SIR values of GelDN/P and GelGP/Th varied by ±2.20% and ±0.75%, respectively, when measured over multiple imaging sessions (3 T). Within a single imaging session, these variations were smaller (±0.17% for GelDN/P and ±0.15% for GelGP/Th). At 1.5 T, the equivalent SIR variations for GelDN/P were ±1.41% (multiple sessions) and ±0.41% (single session), and that for GelGP/Th were ±0.47% (multiple sessions) and ±0.33% (single session).
Sequential changes to the MR sequence parameters resulted in gel SIR variations as follows: 14.07% ± 2.43% (with/without normalization filters), −7.80% ± 0.28% (different echo times, TE), and −5.06% ± 0.59% (selective activation of RF coil elements). The largest variations were noted when the gels were positioned below the scanner isocenter, where SIR measurements were different by 22%.
For the HVs, the SIR values were found to be consistently within 0.64% (single session) for the default sequence. Sequential changes to the MR sequence parameters resulted in SIR variations of −24.47% ± 2.47% (with/without normalization filters), −15.32% ± 7.71% (different echo times, TE), and −2.90% ± 0.78% (selective activation of RF coil elements).

Conclusions
This study has demonstrated that SIR percentage changes from baseline of a similar magnitude to brain gadolinium contrast agent signal hyperintensities can be replicated in phantom models and HVs by altering common MR acquisition parameters and hardware.
Update 2018
Authors: Sanli Yasemin , Zukotynski Katherine , Mittra Erik , Chen Delphine L. , Nadel Helen , Niederkohr Ryan D. , Subramaniam Rathan M. 
Published: November 2018

AbstractThere are recent advances, namely, a standardized method for reporting therapy response (Hopkins criteria), a multicenter prospective cohort study with excellent negative predictive value of18F-FDG PET/CT for N0 clinical neck, a phase III multicenter randomized controlled study establishing the value of a negative posttherapy18F-FDG PET/CT for patient management, a phase II randomized controlled study demonstrating radiation dose reduction strategies for human papilloma virus–related disease, and Food and Drug Administration approval of nivolumab for treatment of recurrent head and neck squamous cell carcinoma.
ACR Practice Parameter for the Performance of Gallium-68 DOTATATE PET/CT for Neuroendocrine Tumors
Authors: Subramaniam Rathan M. , Bradshaw Marques L. , Lewis Kenneth , Pinho Daniella , Shah Chirayu , Walker Ronald C. 
Published: November 2018

Abstract
Radiopharmaceuticals targeting cell surface expression of somatostatin receptors (SSTRs) are particularly useful in the evaluation of neuroendocrine tumors. Gallium-68 DOTA-Tyr3-octreotatate (68Ga-DOTATATE) primarily binds to SSTR type 2 receptors. 68Ga DOTATATE PET/CT is proven to have high impact on the management of neuroendocrine patients compared to traditional anatomical imaging as well as provides additional information over that of conventional nuclear medicine studies (indium-III DTPA-octreotide). It can result in change in management of approximately 75% of patients with neuroendocrine tumors. 68Ga DOTATATE and 18F FDG PET/CT imaging are complementary, with the degree of uptake varying depending on the degree of differentiation of the tumor. Well-differentiated tumors maintain their SSTRs and are positive on 68Ga DOTATATE PET/CT scan, while dedifferentiated tumors are less likely to demonstrate uptake of 68Ga DOTATATE but will demonstrate uptake with 18F FDG PET/CT. In addition, 68Ga DOTATATE PET/CT identifies patients with SSTR expression in their tumors, who have progressed on somatostatin analog therapy, for treatment with 177Lu DOTATATE.
Practical Method for Calculation of Graft Index in Renal Transplant Scintigraphy
Authors: Yazici Bulent 
Published: November 2018

Abstract
Some quantitative indices have been described for renal transplant scintigraphy in evaluating graft dysfunction, some medical complications, and in predicting early and delayed graft function and long-term graft prognosis. Graft index is very useful and more accurate than many other indices in the prediction of delayed graft function and long-term prognosis. In this technical note, the method of calculation of graft index is shown in detail for the authors who want to use this index in further studies or in clinical practice.
Complete Remission After Single Radioiodine Therapy in Malignant Struma Ovarii With Bone and Lymph Node Metastases
Authors: Seifert Philipp , Gühne Falk , Theurer Sarah , Freesmeyer Martin 
Published: November 2018

Abstract
A 67-year-old woman presented with malignant struma ovarii after radical bilateral salpingo-oophorectomy. The surgery revealed a 4.4 cm papillary thyroid carcinoma (follicular variant) within a right-sided ovarian teratoma. 124I sodium iodide positron emission tomography / computed tomography and cervical ultrasound showed 2 slightly hyperfunctional thyroid nodules and several metastases, including bone metastases with intense iodine uptake. Thyroidectomy was necessary in preparation for radioiodine therapy and proofed the thyroid nodules to be benign. Complete remission was achieved by single radioiodine therapy (30 months of follow-up).
Predicting Response to Neoadjuvant Chemotherapy in Patients With Breast Cancer
Authors: Lee Hyunjong , Lee Dong-eun , Park Sohyun , Kim Tae Sung , Jung So-Youn , Lee Seeyoun , Kang Han Sung , Lee Eun Sook , Sim Sung Hoon , Park In Hae , Lee Keun Seok , Kwon Young Mi , Kong Sun Young , Joo Jungnam , Jeong Hae Jeong , Kim Seok-ki 
Published: November 2018

Purpose
The aim of this study was to develop a combined statistical model using both clinicopathological factors and texture parameters from 18F-FDG PET/CT to predict responses to neoadjuvant chemotherapy in patients with breast cancer.

Materials and Methods
A total of 435 patients with breast cancer were retrospectively enrolled. Clinical and pathological data were obtained from electronic medical records. Texture parameters were extracted from pretreatment FDG PET/CT images. The end point was pathological complete response, defined as the absence of residual disease or the presence of residual ductal carcinoma in situ without residual lymph node metastasis. Multivariable logistic regression modeling was performed using clinicopathological factors and texture parameters as covariates.

Results
In the multivariable logistic regression model, various factors and parameters, including HER2, histological grade or Ki-67, gradient skewness, gradient kurtosis, contrast, difference variance, angular second moment, and inverse difference moment, were selected as significant prognostic variables. The predictive power of the multivariable logistic regression model incorporating both clinicopathological factors and texture parameters was significantly higher than that of a model with only clinicopathological factors (P = 0.0067). In subgroup analysis, texture parameters, including gradient skewness and gradient kurtosis, were selected as independent prognostic factors in the HER2-negative group.

Conclusions
A combined statistical model was successfully generated using both clinicopathological factors and texture parameters to predict the response to neoadjuvant chemotherapy. Results suggest that addition of texture parameters from FDG PET/CT can provide more information regarding treatment response prediction compared with clinicopathological factors alone.
Trapping of 18F-Fluciclovine (FACBC) in Superior Sagittal Sinus
Authors: Oldan Jorge Daniel , Miller Seth M. , Barnes Andrew , Khandani Amir Hossein 
Published: November 2018

Abstract
As 18F-fluciclovine (FACBC) becomes more popular, new incidental findings are discovered. We present here a case of a 71-year-old man with prostate cancer in whom an FACBC PET/CT showed uptake in the superior sagittal sinus, which was found to be simply due to a dilated superior sagittal sinus on subsequent MRI. Accumulation in the superior sagittal sinus is a variant that interpreters of FACBC PET/CT should be aware of.
Peritoneal Deciduoid Malignant Mesothelioma on 67Ga SPECT/CT
Authors: Lai Yung-Chi , Wu Yu-Chin , Kao Chia-Hung , Hsieh Te-Chun , Sun Shung-Shung 
Published: November 2018

Abstract
Malignant mesotheliomas may be classified into epithelioid (60%), sarcomatoid (20%), or mixed (20%) type microscopically. Malignant deciduoid mesothelioma, a rare phenotype of epithelioid mesothelioma, arises more commonly from the peritoneum of young women, but is also from the pleura of elderly people. In the current report, the authors describe an unusual case of peritoneal malignant epithelioid mesothelioma with rare deciduoid phenotype demonstrated with 67Ga SPECT/CT.
Intertumoral Heterogeneity of 18F-FDG and 68Ga-PSMA Uptake in Prostate Cancer Pulmonary Metastases
Authors: Perez Paola M. , Hope Thomas A. , Behr Spencer C. , van Zante Annemieke , Small Eric J. , Flavell Robert R. 
Published: November 2018

Abstract
We present a case of a 61-year-old man with history of prostate cancer and rising PSA levels referred for restaging. 68Ga-PSMA-11 PET/CT identified 2 lung nodules with low and moderate PSMA uptake. Subsequent 18F-FDG PET/CT showed high hypermetabolism in the nodule with low PSMA uptake, and low hypermetabolism in the nodule with moderate PSMA uptake. The isolated pulmonary findings and metabolic appearance is an atypical presentation of prostate cancer metastases and raised concern for a second primary malignancy. Fine-needle aspiration of the 18F-FDG active lung nodule confirmed metastatic prostatic adenocarcinoma that subsequently responded to androgen deprivation therapy and abiraterone acetate.
Sorafenib Reduced Significantly Heptopulmonary Shunt in a Large Hepatocelullar Carcinoma
Authors: d'Abadie Philippe , Borbath Ivan , Goffette Pierre , Amini Nadia , Lhommel Renaud 
Published: November 2018

Abstract
An 81-year-old man with a large hepatocellular carcinoma was referred in our institution for 90Y radioembolization (RE). The preliminary arteriography using 99mTc-macroaggregate albumin demonstrated an important hepatopulmonary shunt. It was an exclusion criterion for RE due to high risks of lung radiations. Then, the patient was treated with sorafenib during 4 months, stopped because of grade 3 toxicity. A second liver arteriography was performed, and 99mTc-macroaggregate albumin imaging showed an important reduction of the lung shunt. Transient therapy with sorafenib permitted to close the lung shunt and was a bridge for RE.
Primary Hepatic Neuroendocrine Tumor
Authors: Bai Xia , Zhang Xia , Wang Xuemei 
Published: November 2018

Abstract
A 53-year-old man with tentative diagnosis of likely hepatocellular carcinoma underwent FDG PET/CT, which showed intense activity in both right lobe and caudate lobe of the liver. However, pathology examination from biopsy showed neuroendocrine tumor. He received transarterial chemoembolization and systemic chemotherapy. Posttherapy follow-up FDG PET/CT revealed no abnormal FDG activity in the liver.
Ectopic Papillary Thyroid Carcinoma Mimicking Esophageal Cancer in FDG PET
Authors: Gao Rui , Gao Shan , Jia Xi , Wang Hongyan , Zhang Guangjian 
Published: November 2018

Abstract
Ectopic papillary thyroid carcinoma (PTC) usually occurs along the cervical midline and was barely reported in FDG PET studies. We present a rare case of ectopic PTC within the esophagus with focal FDG activity on FDG PET in a 43-year-old woman who was previously diagnosed as having esophageal cancer based on the endoscopy and PET findings. Surgical pathology revealed the presence of PTC lesion within the muscular layer of the esophagus. Combining this with the negative imaging and laboratory results suggesting a normal thyroid gland led to a diagnosis of primary ectopic PTC.
Revisiting the Many Names of Freeman–Sheldon Syndrome
Authors: Poling Mikaela I. , Dufresne Craig R. 
Published: November 2018

Abstract
While officially designated as distal arthrogryposis type 2A, the condition commonly referred to as Freeman–Sheldon syndrome (FSS) also historically has been termed craniocarpotarsal dystrophy, whistling face syndrome, and craniocarpotarsal dysplasia and classified at different times as a skeletal dysplasia, nonprogressive myopathy, craniofacial syndrome, and distal arthrogryposis. Having previously provided evidence for FSS being a complex myopathic craniofacial syndrome with extra-craniofacial features in most patients, the rationale for revising the FSS eponym and supplanting the current official designation with a new one was based on considerations for educational usefulness, historical accuracy, communication fluency, and nosologic clarity underpinned by genetic, pathologic, and operative experience and outcomes.