bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is aldehyde dehydrogenase inhibited by sulfur compounds? <i>In vitro</i> and <i>in vivo</i> studies
Authors: Iciek Malgorzata , Górny Magdalena , Bilska-Wilkosz Anna , Kowalczyk-Pachel Danuta 
Published: March 2018

Aldehyde dehydrogenase (ALDH) catalyzes the critical step of ethanol metabolism, i.e. transformation of toxic acetaldehyde to acetic acid. It is a redox sensitive protein with the key Cys in its active site. Recently, it has been documented that activity of some proteins can be modified by sulfur-containing molecules called reactive sulfur species leading to the formation of hydropersulfides. The aim of the present study was to examine whether ALDH activity can be modified through this way.Studies were performed in vitro using yeast ALDH and various reactive sulfur species, including Na2S, GSSH, K2Sx, Na2S2O3, and garlic-derived allyl sulfides. The effect of garlic-derived trisulfide on ALDH activity was also studied in vivo in the rat liver.The obtained results clearly demonstrated that ALDH could be regulated by sulfur species which inhibited its enzymatic activity. The results also suggested that not H2S but polysulfides or hydropersulfides were the oxidizing species responsible for this modification. This process was easily reversible by reducing agents. After the treatment with polysulfides or hydropersulfides the level of protein-bound sulfur increased, while the activity of the enzyme dramatically decreased. Moreover, the study demonstrated that ALDH activity was inhibited in vivo in the rat liver after garlic-derived trisulfide administration. This is the first study reporting the regulation of ALDH activity by sulfane sulfur species and the results suggest that it led to the inhibition of the enzyme.
Estanislao Zuleta: educación con filosofía
Authors: Pulido Cortés Óscar 
Published: March 2018

Este artículobusca presentar los rasgos fundamentales del pensamiento educativo delpensador colombiano Estanislao Zuleta, a través de su obra creadora.Seprocede a partir de un rastreo conceptual y discursivo de los textos publicados por el autor y de sus vivencias educativas, contadas principalmente en algunas entrevistas y testimonios. Eltexto está estructurado endos partes: la primerapresenta situaciones, escenas ydatos relativos al autor en su contexto formativo, pues estas condiciones determinansusapuestas sobre la educaciónenformas teóricas yprácticas, la segunda parte, presenta los principales aspectos del pensamiento educativo de Zuleta: el autodidactismo o la opción autónoma por elsaber, el enseñar apensar, la educación con filosofía yla educación para la democracia.
Pengaruh Modal, Lama Usaha dan Lokasi Terhadap Pendapatan Pedagang Pasar Pasca Relokasi
Authors: Setiaji Khasan , Fatuniah Ana Listia 
Published: March 2018

This study aims to find out the effect of capital, length of trading, and location toward the traders income Johar market in Semarang City both simultenously and partially. The sample is 92 traders. The result of the study showed that the significant value of 0,000 < 0,05 and the value of Fcount (74,922) is higher than Ftable(2,71) and Adjust R Square of 0,709 (70,9%). Capital gives positive effect on traders income in Johar market Semarang obtains the significant value of 0,000 < 0,05 and the value of tcount(5,853) higher than ttable (1,987) and r-squareof 27,9%. The length of trading gives positive effect on traders income in Johar market Semarang obtains the significant value of 0,000< 0,05 and the value of tcount(3,635) higher than ttable(1,987) and r-squareof 13,0%. Location gives positive effect on the traders income in Johar market Semarang obtains the significant value of 0,000 < 0,05 and the value of tcount(4,658) higher than ttable (1,987) and r-square of 19,8%. The conclusion is that there is a positive effect of capital, length, and location of trading toward the traders income Johar market in Semarang City.
Worst-Case Investment Strategy with Delay
Authors: A Chunxiang , Shao Yi 
Published: March 2018

AbstractThis paper considers a worst-case investment optimization problem with delay for a fund manager who is in a crash-threatened financial market. Driven by existing of capital inflow/outflow related to history performance, we investigate the optimal investment strategies under the worst-case scenario and the stochastic control framework with delay. The financial market is assumed to be either in a normal state (crash-free) or in a crash state. In the normal state the prices of risky assets behave as geometric Brownian motion, and in the crash state the prices of risky assets suddenly drop by a certain relative amount, which induces to a dropping of the total wealth relative to that of crash-free state. We obtain the ordinary differential equations satisfied by the optimal investment strategies and the optimal value functions under the power and exponential utilities, respectively. Finally, a numerical simulation is provided to illustrate the sensitivity of the optimal strategies with respective to the model parameters.
Improved Monitoring System for Heavy-Oil Steam-Assisted-Gravity-Drainage Wells
Authors: Carpenter Chris 
Published: March 2018

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 187441, “Improved Monitoring System for Heavy-Oil Steam-Assisted-Gravity-Drainage Wells,” by Christopher Baldwin, Weatherford, prepared for the 2017 SPE Annual Technical Conference and Exhibition, San Antonio, Texas, USA, 8–11 October. The paper has not been peer reviewed.
The complete paper provides an overview of the development of fiber-optic sensing for steam-assisted-gravity-drainage (SAGD) applications, including a review of more than 10 years of work in development and field applications in western Canada. Information provided in this paper is applicable beyond SAGD applications. The fiber-optic monitoring systems might also be used for intelligent, subsea, and unconventional wells.
Introduction
One area that has benefited from the unique advantages of fiber-optic sensing is thermal monitoring of SAGD wells. One particular fiber-optic technology that has proved successful in these thermal-monitoring applications is wavelength-domain multiplexing of Bragg-grating-based fiber-optic sensors. Commonly referred to as array temperature sensing (ATS), the Bragg-grating arrays can be manufactured splice-free for long-term reliability. The number of thermal sensing points can range from a few to well over 100 for a single cable. Each Bragg-grating sensing point provides a real-time, accurate measurement of temperature at that location along the wellbore. ATS systems have been used successfully to monitor the steam-injection and production processes in SAGD wells. ATS systems are capable of performing more-accurate temperature measurements and are able to resolve much smaller temperature features compared with distributed temperature sensing (DTS).
Bragg-grating optical sensors not only provide temperature measurements but also can be packaged in a transducer to provide pressure and temperature (PT) also can be packaged in a transducer to provide pressure and temperature (PT) readings. The optical PT gauge is compatible with the surface instrumentation that records the ATS responses, allowing for the PT gauge to be integrated at the end of the ATS optical fiber for single-wellhead penetration, providing multiplexed DTS and PT measurements.
Environmental Effects on Downhole Fiber-Optic Sensors
The requirements for a successful monitoring system in SAGD applications are dictated by the harsh environments experienced downhole. In the past, the presence of hydrogen in these applications has caused issues with various fiber-optic sensing technologies. Improvements in optical-fiber design and downhole cable construction have helped to mitigate some of these issues, but any downhole monitoring system must be able to cope with the presence of hydrogen in relatively high-temperature environments.
Technology Focus: Heavy Oil (March 2018)
Authors: Babadagli Tayfun 
Published: March 2018

Technology Focus
Despite the recent downturn, a significant number of pilot- or demonstration-scale applications of existing technologies to develop new heavy-oil fields or new technologies to develop existing fields have been reported over the past year. I have selected two of them (SPE 184974 and SPE 184154) in this issue. While they might be projects that started a few years ago when oil prices were at a peak level, they are interesting and still relevant because the projects have continued and valuable results and observations have been shared.
Reported cases of cost-effective applications such as well stimulation using chemicals and solvents have also been prominent over the past few years. Well-based applications such as stimulation or production optimization (SPE 184094) are quite useful to improve the productivity in smaller fields. On the other hand, efforts on cost reduction in large-scale thermal projects were obvious. Yet, in laboratory-scale experimental investigations, observations on the use of nanoparticles (SPE 184117) and new- generation chemicals to improve the efficiency of large-scale thermal and non-thermal (mainly chemical flooding) applications are very promising. I also would like to mention high-tech imaging applications to map the heat distribution in field-scale applications (SPE 184971).
The areas listed seem to be the trend of new research studies and field applications along with optimization attempts on the basis of data-driven modeling. The focus will also be on new technology attempts toward the reduction of the cost of heavy-oil production, including lower-cost (solar panels) and in-situ steam generation (SPE 184118), minimizing steam needs by use of chemical additives and solvents (solvent-aided thermal—steam or electromagnetic—processes), and nonthermal applications (well stimulation by chemicals and solvents).
I hope to read more papers in the coming years on the philosophical approaches to describing the problems and limitations of existing solutions because complex heavy-oil applications still need more effort on model development and experimental data generation. I included SPE 185633 in this issue as a good example of this kind of attempt.
Recommended additional reading at OnePetro: www.onepetro.org.
SPE 184118 In-Situ Steam Generation: A New Technology Application for Heavy-Oil Production by Ayman R. Al-Nakhli, Saudi Aramco, et al.
SPE 184117 Experimental Study for Enhancing Heavy-Oil Recovery by Nanofluid Followed by Steam Flooding NFSF by Osamah Alomair, Kuwait University, et al.
SPE 184094 Fluidic-Diode Autonomous Inflow-Control Device for Heavy-Oil Application by Georgina Corona, Halliburton, et al.
SPE 184971 Satellite Monitoring of Cyclic Steam Stimulation Without Corner Reflectors by Michael D. Henschel, MDA, et al.
Pea and Barley Forage as Fallow Replacement for Dryland Wheat Production
Authors: Miller Perry , Glunk Emily , Holmes Jeff , Engel Richard 
Published: March 2018

Core Ideas
Forage yields from pea, especially winter pea, were competitive with hay barley yields.Crude protein yield from pea forage was 40 to 110% greater than barley.Crop harvest at the bloom stage used the least soil water and nitrogen.Wheat yield following pea averaged 82 to 88% of that on chemical fallow.
There is a growing interest in the use of annual forages in rotation with wheat (Triticum aestivum L.). The objectives of this study were to: (i) compare forage yield and quality of spring and winter pea (Pisum sativum L.), barley (Hordeum vulgare L.), and a pea–barley mixture harvested at flowering (early), pod (late), or grown to maturity; and (ii) compare the cropping‐sequence effects of these cropping treatments for three N fertilizer rates, subsequent wheat yield, and grain quality relative to chemical fallow. This study was conducted at Amsterdam, MT, from 2003 to 2006. Pea forage yield at the pod stage was 1.2 Mg ha−1 (30%) and 3.7 Mg ha−1 (60%) greater than at the flower stage for spring and winter pea, respectively. At the same harvest times, spring barley forage averaged 1.8 Mg ha−1 (32%) greater either as a sole species or when mixed with spring pea. Forage quality of pea forage was high regardless of harvest timing. Protein yield for spring and winter pea forage averaged 0.28 (60%) and 0.38 Mg ha−1 (81%) greater than the barley forage treatments across harvest times and years. Significant differences in stored soil water (19 mm) and soil nitrate N (10 kg N ha−1) were found between flowering and pod forage harvest timing in pea, but these differences only nominally affected subsequent wheat yield or quality. Wheat following pea averaged approximately 85% of the yield on chemical fallow. Among the cropping treatments, the greatest wheat yield and protein occurred following winter pea harvested at the flower stage.
Contribution of Secondary Traits for High Grain Yield and Stability of Tropical Maize Germplasm across Drought Stress and Non‐Stress Conditions
Authors: Musvosvi Cousin , Setimela Peter S. , Wali Mruthunjaya C. , Gasura Edmore , Channappagoudar Basavangouda B. , Patil Shreekant S. 
Published: March 2018

Core Ideas
In a drought and non‐stress breeding program, secondary traits are important in contributing to the identification of high yielding and stability maize genotypes.Designing selection strategies that enhance grain yield gains and stability.The traits tassel size, ear aspect, ear diameter, and kernel weight per ear were found to have high broad sense heritability and can effectively aid simultaneous for selection for high grain yield and stability.
Information is needed on the contribution of secondary traits to grain yield and stability in maize (Zea mays L.). This study aimed at identifying stable and high yielding hybrids as well as traits contributing to high yield and stability in tropical maize. Twenty‐two test hybrids and six check hybrids were evaluated under five environments in Karnataka, India, using a 4 × 7 α‐lattice design with two replications. Genotype main effect plus genotype × environment interaction biplot model was used to ascertain genotype stability and yield across environments. Genotype × trait biplot, t test, and step‐wise regression analyses were used to determine trait expression differences between high yielding and stable, and low yielding and unstable hybrids. Genotypic correlations and heritability were used to estimate correlated response to selection for grain yield via each secondary trait. Mean grain yield under drought was 20% of that across environments, thus selection in both drought and non‐drought stress environments is required. Hybrids GH‐12444 and GH‐12408 were high yielding and stable across environments, and should be tested widely. Some traits, such as tassel size, had correlated response to selection values of near unity making them unsuitable for indirect selection. However, such traits could be used to supplement selection for grain yield given their high heritability and that they are relatively easy to measure. Different traits were associated with grain yield under different conditions thus suggesting that both drought and non‐drought stress conditions must be used as selection environments using secondary traits specific to a given environment.
Development, Validation and Application of HPLC Method for Metformin in Rabbit Plasma
Authors: Ubaid Muhammad , Ahmad Mahmood , Khan Farhan Ahmad , Murtaza Ghulam 
Published: March 2018

Objective:This study was aimed at conducting a pharmacokinetic evaluation of metformin in rabbit plasma samples using rapid and sensitive HPLC method and UV detection.Methods:Acetonitrile was used for protein precipitation in the preparation of plasma samples. Reverse phase chromatography technique with silica gel column (250 mm × 4.6 mm, 5 μm) at 30°was used for the separation purpose. Methanol and phosphate buffer (pH 3.2) mixture was used as a mobile phase with flow rate 0.8 ml/min. The wavelength of UV detector was adjusted at 240 nm.Results:The calibration curve was linear in a range of 0.1-1 µg/ml with R² = 0.9982. The precision (RSD, %) values were less than 2%, whereas, accuracy of method was higher than 92.37 %. The percentage recovery values ranged between 90.14 % and 94.97 %. LOD and LOQ values were 25 ng/ml and 60 ng/ml, respectively. Cmax and AUC0-t values were found to be 1154.67 ± 243.37 ng/ml and 7281.83 ± 210.84 ng/ml.h, respectively after treating rabbits with a formulation containing 250 mg metformin.Conclusion:Based on the above findings, it can be concluded that present method is simple, precise, rapid, accurate and specific and thus, can be efficiently used for the pharmacokinetic study of metformin.
PENGEMBANGAN MODUL BAHASA INDONESIA BERMUATAN NILAI KARAKTER KEBANGSAAN BAGI MAHASISWA PGSD
Authors: Subekti Tabah 
Published: March 2018

The research aims to develop module of bahasa which combined by national character. Background of this study is there’s not yet any module of bahasa which combined by national character, in the other side Indonesia needs teacher who able to teach and guide the children with national character to tighten the children’s nationality. By using this product, we hope that the student of elementary school teacher education (candidate of teacher) will able to teach and guide the children with national character. The research was supported by the expert in each field. The research divided become four step which called four-D (1) define; (2) design; (3) develop; and (4) disseminate. But, the duration of the research is only one year, so it caused the research only able to achieve third level (develop). The product of this research is a module of bahasa combined by national character which ready to used by lecturer in elementary school teacher education. Object of the research are the student of elementary school teacher education (candidate of teacher) in University of Muhammadiyah Magelang, Central Java. The result of the study described that development of module bahasa is done effectively. It can be seen from the lecturers and students respond who had helped by the module.Keywords: Module, character.
PENERAPAN MENGARANG TERBIMBING MODEL KWL (KNOW,WANT, LEARNED) DENGAN MENGGUNAKAN MEDIA GAMBAR UNTUK MENINGKATKAN KEMAMPUAN MENULIS KARANGAN NARASI SISWA KELAS IV SEKOLAH DASAR
Authors: Sutarna Nana 
Published: March 2018

Kemampuan siswa menulis karangan narasi narasi di kelas IV SDN Cengal III, Kabupaten Kuningan belum mencapai pada tingkat yang diharapkan. Salah satu cara yang dianggap tepat untuk menyelesaikan permasalahan tersebut adalah melalui penerapan pembelajaran mengarang terbimbing model KWL melalui media gambar. Penelitian ini menggunakan metode penelitian tindakan kelas (classroom action research) dengan menggunakan pendekatan kualitatif. Desain penelitian tindakan kelas yang digunakan dalam penelitian ini mengacu pada model Kemmis dan Mc Taggart yang dimulai dengan tahap perencanaan, pelaksanaan tindakan, observasi, dan refleksi. Instrumen penelitian yang digunakan yaitu pedoman observasi aktivitas siswa, pedoman wawancara, catatan lapangan, dan soal. Data yang telah terkumpul kemudian diolah dan dianalisis. Sedangkan pengecekan keabsahan data menggunakan teknik triangulasi, member check, dan expert opinion. Melalui penerapan pembelajaran mengarang terbimbing model KWL melalui media gambar dalam pembelajaran menulis karangan narasi narasi, hasil belajar siswa kelas IV SDN Cengal III mengalami peningkatan. Hal ini terbukti dengan bertambahnya jumlah siswa yang dinyatakan tuntas pada setiap siklusnya dimulai dari data awal sebanyak 3 orang siswa atau 15%, siklus I meningkat menjadi 9 orang atau 45%, pada siklus II meningkat menjadi 18 orang atau 90%.
Pengalaman Hidup Orang Terinfeksi Filariasis
Authors: Lismayanti Lilis , Ibrahim Kusman , Meilianingsih Lia 
Published: March 2018

Filariasis merupakan penyakit yang kurang diperhatikan, karena penderita cenderung mengalami stigma negatif. Penelitian ini bertujuan mengeksplorasi pengalaman hidup orang terinfeksi filariasis. Penelitian menggunakan metode deskriptif kualitatif dengan pendekatan fenomenologi. Tujuh partisipan berpartisipasi dalam penelitian ini. Analisis data menggunakan pendekatan Collaizi. Hasil penelitian mendapatkan lima tema dan 16 subtema. Pertama, pengalaman pertama kali terinfeksi filariasis dengan subtema kaget, bingung, dan perasaan tidak menentu. Kedua, pengalaman orang terinfeksi filariasis selama menjalani gejala klinisnya dengan subtema demam, nyeri, bengkak, keterbatasan aktivitas, dan kelelahan. Ketiga, gangguan emosi dan psikologis dengan subtema malu, jengkel, dan pasrah. Keempat, adanya beban sosial ekonomi dengan subtema menarik diri dari interaksi sosial dan kesulitan ekonomi. Kelima, pengalaman orang terinfeksi filariasis dalam mengakses pelayanan kesehatan dengan subtema penyakit yang tidak kunjung sembuh setelah beberapa kali berobat ke pelayanan kesehatan, mencari alternatif pengobatan, pelayanan kesehatan yang kurang memuaskan dan harapan pelayanan kesehatan yang lebih baik. Hasil penelitian ini dapat dijadikan acuan untuk meningkatkan pelayanan keperawatan komunitas, baik pada kelompok yang sakit, yang beresiko dan yang sehat, dengan upaya promotif, preventif, kuratif dan rehabilitatif.Kata kunci: Fenomenologi, filariasis, pengalaman hidupÂ AbstractFilariasis is a disease that is less noted, because people with filariasis tend to experience negative stigma. This study aims to explore the lived experience of people infected with filariasis. This study is descriptive qualitative with phenomenological approach. Seven (7) participants involved in this study. Data was analized using Collaiziâ€™s approach to analysis. The results of this study found 5 themes with 16 subthemes. First, the experience at first infected with filariasis with subthemes: shock, confusion, and feeling uncertain. Second, filariasis infected people experience during their clinical symptoms with subtheme: Fever, pain, swelling, lack of activity, and fatigue. Third, filariasis infected people experience of emotional and psychological disturbance with subthemes: Shame, irritated, and surrender. Fourth, Socioeconomic burden with subthemes: withdraw from social interaction and economic hardship. Fifth, filariasis infected people experience in accessing health services with subthemes: Never recovered after several times getting treatment by health professional, seeking alternative treatment, unsatisfactory with health services and expectation of better health care. The results of this study can be used as a reference to improve community nursing services, either at hospital group, risk and healthy people, with promotive, preventive, curative and rehabilitative.Key words: Filariasis, lived experience, phenomenology