bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation
Authors: Li Qiyao , Li Ying , Min Tianliang , Gong Junyi , Du Lili , Phillips David Lee , Liu Junkai , Lam Jacky W. Y. , Sung Herman H. Y. , Williams Ian D. , Kwok Ryan T. K. , Ho Chun Loong , Li Kai , Wang Jianguo , Tang Ben Zhong 
Published: September 2019

AbstractPathogen infections and cancer are two major human health problems. Herein, we report the synthesis of an organic salt photosensitizer (PS), called 4TPA‐BQ, by a one‐step reaction. 4TPA‐BQ presents aggregation‐induced emission features. Owing to the aggregation‐induced reactive oxygen species generated and a sufficiently small ΔEST, 4TPA‐BQ shows a satisfactorily high 1O2 generation efficiency of 97.8 %. In vitro and in vivo experiments confirmed that 4TPA‐BQ exhibited potent photodynamic antibacterial performance against ampicillin‐resistant Escherichia coli with good biocompatibility in a short time (15 minutes). When the incubation duration persisted long enough (12 hours), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time‐dependent fluorescence‐guided photodynamic therapy in one individual PS, which achieves ordered and multiple targeting simply by varying the external conditions. 4TPA‐BQ reveals new design principles for the implementation of efficient PSs in clinical applications.
Nucleophilie von Glutathion als Bindeglied zur Reaktivität von Michael‐Akzeptoren
Authors: Mayer Robert J. , Ofial Armin R. 
Published: September 2019

AbstractDeprotoniertes Glutathion gehört zu den potentesten biologischen Nucleophilen und spielt durch die Bildung kovalenter Konjugate mit Michael‐Akzeptoren eine wichtige physiologische Rolle bei der Zellentgiftung. Die ElektrophilieEverschiedener Michael‐Akzeptoren wurde kürzlich auf Basis der Patz‐Mayr‐Gleichung lg k2=sN(N+E) charakterisiert. Wir haben nun die nucleophile Reaktivität (N,sN) von Glutathion (GSH) in wässriger Lösung bei 20 °C bestimmt, um publizierte GSH‐Reaktivitäten (kGSH) mit der Mayr‐Elektrophilieskala zu verbinden. Auf diese Weise lässt sich die ElektrophilieEvon mehr als 70 Michael‐Akzeptoren abschätzen, was dazu genutzt werden kann, systematisch neue Reaktionen mit einer Vielzahl an Nucleophilen vorherzusagen, deren NucleophilieparameterN/sNbekannt sind.
Visible‐Light‐Driven Janus Microvehicles in Biological Media
Authors: Pacheco Marta , Jurado‐Sánchez Beatriz , Escarpa Alberto 
Published: September 2019

AbstractA light‐driven multifunctional Janus micromotor for the removal of bacterial endotoxins and heavy metals is described. The micromotor was assembled by using the biocompatible polymer polycaprolactone for the encapsulation of CdTe or CdSe@ZnS quantum dots (QDs) as photoactive materials and an asymmetric Fe3O4 patch for propulsion. The micromotors can be activated with visible light (470–490 nm) to propel in peroxide or glucose media by a diffusiophoretic mechanism. Efficient propulsion was observed for the first time in complex samples such as human blood serum. These properties were exploited for efficient endotoxin removal using lipopolysaccharides from Escherichia coli O111:B4 as a model toxin. The micromotors were also used for mercury removal by cationic exchange with the CdSe@ZnS core–shell QDs. Cytotoxicity assays in HeLa cell lines demonstrated the high biocompatibility of the micromotors for future detoxification applications.
Bifunctional Small‐Molecule Ligands of K‐Ras Induce Its Association with Immunophilin Proteins
Authors: Zhang Ziyang , Shokat Kevan M. 
Published: September 2019

AbstractHere we report the design, synthesis, and characterization of bifunctional chemical ligands that induce the association of Ras with ubiquitously expressed immunophilin proteins such as FKBP12 and cyclophilin A. We show this approach is applicable to two distinct Ras ligand scaffolds, and that both the identity of the immunophilin ligand and the linker chemistry affect compound efficacy in biochemical and cellular contexts. These ligands bind to Ras in an immunophilin‐dependent fashion and mediate the formation of tripartite complexes of Ras, immunophilin, and the ligand. The recruitment of cyclophilin A to GTP‐bound Ras blocks its interaction with B‐Raf in biochemical assays. Our study demonstrates the feasibility of ligand‐induced association of Ras with intracellular proteins and suggests it as a promising therapeutic strategy for Ras‐driven cancers.
Rhodium‐Catalyzed C−H Activation Enabled by an Indium Metalloligand
Authors: Yamada Ryosuke , Iwasawa Nobuharu , Takaya Jun 
Published: September 2019

AbstractRhodium complexes with an indium metalloligand were successfully synthesized by utilizing a pyridine‐tethered cyclopentadienyl ligand as a support for an In−Rh bond. The indium metalloligand dramatically changes the electronic and redox properties of the rhodium metal, thereby enabling catalysis of sp2C−H bond activation.
Strong Enhancement of π‐Electron Donor/Acceptor Ability by Complementary DD/AA Hydrogen Bonding
Authors: Liu Cheng‐Hao , Niazi Muhammad Rizwan , Perepichka Dmitrii F. 
Published: September 2019

Abstractπ‐Conjugated organic materials possess a wide range of tunable optoelectronic properties which are dictated by their molecular structure and supramolecular arrangement. While many efforts have been put into tuning the molecular structure to achieve the desired properties, rational supramolecular control remains a challenge. Here, we report a novel series of supramolecular materials formed by the co‐assembly of weak π‐electron donor (indolo[2,3‐a]carbazole) and acceptor (aromatic o‐quinones) molecules via complementary hydrogen bonding. The resulting polarization creates a drastic perturbation of the molecular energy levels, causing strong charge transfer in the weak donor–acceptor pairs. This leads to a significant lowering (up to 1.5 eV) of the band gaps, intense absorption in the near‐IR region, very short π‐stacking distances (≥3.15 Å), and strong ESR signals in the co‐crystals. By varying the strength of the acceptor, the characteristics of the complexes can be tuned between intrinsic, gate‐, or light‐induced semiconductivity with a p‐type or ambipolar transport mechanism.
Nucleophilicity of Glutathione: A Link to Michael Acceptor Reactivities
Authors: Mayer Robert J. , Ofial Armin R. 
Published: September 2019

AbstractDeprotonated glutathione is among the most potent biological nucleophiles and plays an important physiological role in cellular detoxification by forming covalent conjugates with Michael acceptors. The electrophilicityEof various Michael acceptors was characterized recently according to the Patz–Mayr relation lg k2=sN(N+E). We now determined the nucleophilic reactivity (N,sN) of glutathione (GSH) in aqueous solution at 20 °C to connect published GSH reactivities (kGSH) with Mayr's electrophilicity scale (E). In this way, electrophilicitiesEof more than 70 Michael acceptors could be estimated, which can now be used to systematically predict novel reactions with the multitude of nucleophiles whose nucleophilicity parametersN/sNare known.
Controlled Growth of CH3NH3PbBr3 Perovskite Nanocrystals via a Water–Oil Interfacial Synthesis Method
Authors: Li Fangfang , Cao Liya , Shi Shuangshuang , Gao Heng , Song Li , Geng Chong , Bi Wengang , Xu Shu 
Published: September 2019

AbstractFundamental insights into the reaction kinetics of organic–inorganic lead halide perovskite nanocrystals (LHP NCs) are still limited due to their ultrafast formation rate. Herein, we develop a water–oil interfacial synthesis of MAPbBr3 NCs (MA=CH3NH3+), which prolongs the reaction time to tens of minutes. This method makes it possible to monitor in situ the formation process of MAPbBr3 NCs and observe successive spectral evolutions from 438 to 534 nm in a single reaction by extending reaction time. The implementation of this method depends on reducing the formation rate of PbBr64− octahedra and the diffusion rate of MA. The formation of PbBr64− is a rate‐determining step, and the biphasic system offers a favorable reaction condition to control the mass transfer of MA. The effects of temperature and concentration of precursor and ligand are investigated in detail.
Self‐Assembly of a Phosphate‐Centered Polyoxo‐Titanium Cluster: Discovery of the Heteroatom Keggin Family
Authors: Li Ning , Liu Jiang , Liu Jing‐Jing , Dong Long‐Zhang , Li Shun‐Li , Dong Bao‐Xia , Kan Yu‐He , Lan Ya‐Qian 
Published: September 2019

AbstractOver the past 200 years, the most famous and important heteroatom Keggin architecture in polyoxometalates has only been synthesized with Mo, W, V, or Nb. Now, the self‐assembly of two phosphate (PO43−)‐centered polyoxo‐titanium clusters (PTCs) is presented, PTi16 and PTi12, which display classic heteroatom Keggin and its trivacant structures, respectively. Because TiIV has lower oxidate state and larger ionic radius than MoVI, WVI, VV, and NbV, additional TiIV centres in these PTCs are used to stabilize the resultant heteroatom Keggin structures, as demonstrated by the cooresponding theoretical calculation results. These photoactive PTCs can be utilized as efficient photocatalysts for highly selective CO2‐to‐HCOOH conversion. This new discovery indicates that the classic heteroatom Keggin family can be assembled with Ti, thus opening a research avenue for the development of PTC chemistry.
Coordination Booster‐Catalyst Assembly: Remote Osmium Outperforming Ruthenium in Boosting Catalytic Activity
Authors: Mandal Tanmoy , Singh Vivek , Choudhury Joyanta 
Published: September 2019

AbstractPresented herein is a set of bimetallic and trimetallic “coordination booster‐catalyst” assemblies in which the coordination complexes [RuII(terpy)2] and [OsII(terpy)2] acted as boosters for enhancement of the catalytic activity of [RuII(NHC)(para‐cymene)]‐based catalytic site. The boosters accelerated the oxidative loss of para‐cymene from the catalytic site to generate the active catalyst during the oxidation of alkenes and alkynes into corresponding aldehydes, ketones and diketones. It was found that the boosting efficiency of the [OsII(terpy)2] units was considerably higher than its congener [RuII(terpy)2] unit in these assemblies. Mechanistic studies were conducted to understand this unique improvement.
A novel ABCD1 gene mutation causes adrenomyeloneuropathy in a Chinese family
Authors: Wang Chao , Liu Hongchao , Han Bing , Zhu Hui , Liu Jingyao 
Published: September 2019

AbstractBackgroundAdrenomyeloneuropathy (AMN) is a rare genetic disease. In this study, a case of AMN was uncovered in a Chinese family.MethodsClinical manifestations were collected and observed through medical records, physical examination, laboratory tests, and magnetic resonance imaging (MRI). Generation sequencing of the ABCD1 gene was performed, and the pedigree of the family was analyzed.ResultsThe proband suffered from adrenocortical insufficiency at 8 years old and presented with a slowly progressive gait disorder at 21 years old. Physical examination, laboratory tests, and MRI showed that he had adult‐onset AMN manifestations, including spasticity and hyperactive tendon reflexes with Hoffman and Babinski signs in the limbs, difficulty in performing the heel‐to‐shin test, hyperpigmentation, increased levels of adrenocorticotropic hormone and very long‐chain fatty acids, decreased levels of corticosteroid and serum gesterol, and salient atrophy of the cervical and thoracic spinal cord. DNA analysis revealed a missense variant, c.290A>C (p.His97Pro) in exon 1 of the ABCD1 gene, in the proband. Sanger sequencing confirmed that the proband's mother was heterozygous for the same variant. The ABCD1 gene mutation transmitted in an X‐linked inheritance manner.ConclusionA novel missense mutation in the ABCD1 gene was identified in a Chinese family, which caused an unusual manifestation of adult‐onset AMN. This discovery is beneficial for the genetic counseling of patients with X‐linked adrenoleukodystrophy.
Clinical outcomes for ibrutinib in relapsed or refractory mantle cell lymphoma in real‐world experience
Authors: Jeon Young‐Woo , Yoon Seugyun , Min Gi June , Park Sung‐Soo , Park Silvia , Yoon Jae‐Ho , Lee Sung‐Eun , Cho Byung‐Sik , Eom Ki‐Seong , Kim Yoo‐Jin , Kim Hee‐Je , Lee Seok , Min Chang‐Ki , Lee Jong Wook , Cho Seok‐Goo 
Published: September 2019

AbstractIbrutinib is highly effective in patients with relapsed or refractory mantle cell lymphoma (MCL) in major clinical trials. Although there has been a dramatic improvement in survival outcomes in the salvage setting, nonresponders to ibrutinib have a bleak prognosis. Therefore, this retrospective study was conducted to identify the most appropriate therapeutic strategy and prognosis‐related factors to predict the response of patients with relapsed or refractory MCL to ibrutinib monotherapy. Thirty‐three consecutive refractory or relapsed MCL patients treated with ibrutinib were analyzed in this study. The median overall survival (OS) and progression‐free survival (PFS) after initiation of ibrutinib were 35.1 months and 27.4 months, respectively. Risk factor analysis showed that high risk according to the Mantle Cell Lymphoma International Prognostic Index (MIPI) and nonresponse to ibrutinib at the first three cycles were significantly associated with inferior OS. Poor PFS was associated with high‐risk biologic MIPI, prior bendamustine exposure, and nonresponse to ibrutinib during the first three cycles. After ibrutinib failure, primary nonresponders had poorer OS and PFS than inconsistent responders. The overall response rate for the first salvage therapy was only 33%, with a median TTP of 3.2 months. There was no effective therapeutic strategy except for allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Although ibrutinib responders exhibited favorable survival outcomes, nonresponders had a dismal prognosis. To overcome these limitations, it may be necessary to modify therapeutic strategies, such as selecting inconsistent responders for earlier allo‐HSCT.
Thyroid dose‐volume thresholds for the risk of radiation‐related hypothyroidism in nasopharyngeal carcinoma treated with intensity‐modulated radiotherapy—A single‐institution study
Authors: Huang Cheng‐Long , Tan Hong‐Wen , Guo Rui , Zhang Yuan , Peng Hao , Peng Liang , Lin Ai‐Hua , Mao Yan‐Ping , Sun Ying , Ma Jun , Tang Ling‐Long 
Published: September 2019

AbstractBackgroundTo identify thyroid dose‐volume thresholds for radiotherapy (RT)‐related hypothyroidism (HT) in patients with nasopharyngeal carcinoma (NPC) treated with intensity‐modulated RT (IMRT). In this way, we desired to guide the design of treatment plans and, finally, lower HT prevalence.MethodsIn total, 345 NPC patients treated with IMRT were evaluated retrospectively during a median follow‐up of 45.2 (range, 11.3‐64.9) months. Serum‐based assessments of thyroid function before and after IMRT were monitored periodically. Thyroid dose‐volume parameters were analyzed for their association with HT risk.ResultsIn total, 44.1% of patients (152/345) developed primary HT. Analyses of thyroid dose‐volume parameters identified a stringent dose‐volume histogram (DVH) threshold defined by V25Gy (the percentage thyroid volume that receives >25 Gy, not the absolute volume) ≤60%, V35Gy ≤ 55%, and V45Gy ≤ 45%. Patients whose thyroid DVHs satisfied these constraints had a lower prevalence of 2‐year HT compared with the overall prevalence (13.2% vs 25.8%, P < .001). Another DVH was defined by V25Gy > 95%, V35Gy > 90%, and V45Gy > 75%, and patients whose thyroid DVHs satisfied with these constraints had a higher prevalence of 2‐year HT than the overall incidence (36.0% vs 25.8%, P < .001).ConclusionWe recommend V25Gy ≤ 60%, V35Gy ≤ 55%, and V45Gy ≤ 45% as the “stringent” DVH line, and V25Gy > 95%, V35Gy > 90%, and V45Gy > 75% as the “inhibition” DVH line, under the precondition of not compromising the target coverage. These findings could help in the design of individual treatment plans and, eventually, to lowering of HT prevalence.
Isotopically Labeled Clickable Glutathione to Quantify Protein S‐Glutathionylation
Authors: VanHecke Garrett C. , Yapa Abeywardana Maheeshi , Huang Bo , Ahn Young‐Hoon 
Published: September 2019

AbstractProtein S‐glutathionylation is one of the important cysteine oxidation events that regulate various redox‐mediated biological processes. Despite several existing methods, there are few proteomic approaches to identify and quantify specific cysteine residues susceptible to S‐glutathionylation. We previously developed a clickable glutathione approach that labels intracellular glutathione with azido‐Ala by using a mutant form of glutathione synthetase. In this study, we developed a quantification strategy with clickable glutathione by using isotopically labeled heavy and light derivatives of azido‐Ala, which provides the relative quantification of glutathionylated peptides in mass spectrometry‐based proteomic analysis. We applied isotopically labeled clickable glutathione to HL‐1 cardiomyocytes, quantifying relative levels of 1398 glutathionylated peptides upon addition of hydrogen peroxide. Importantly, we highlight elevated levels of glutathionylation on sarcomere‐associated muscle proteins while validating glutathionylation of two structural proteins, α‐actinin and desmin. Our report provides a chemical proteomic strategy to quantify specific glutathionylated cysteines.
A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
Authors: Liu Jun , Agyapong George , Misra Debashish , Taylor C. Douglas , Hirsh David A. 
Published: September 2019

AbstractCurrent safety data affirms enzalutamide does not cause clinically significant liver dysfunction that warrant therapy cessation. Therefore, clinicians should not withhold potentially successful therapy merely for suspected hepatotoxicity or PnC.
Long‐term survival after surgery of pancreatic primary squamous cell carcinoma: A case report and literature review
Authors: Taibi Abdelkader , Jacques Jeremie , Durand Fontanier Sylvaine , Charissoux Aurelie , Bardet Sylvia M. , Christou Niki , Fredon Fabien , Valleix Denis , Mathonnet Muriel 
Published: September 2019

AbstractPancreatic primary squamous cell carcinoma is rarer and no optimal treatment has been validated according to the tumor stage. The surgical resection was the only curative option. The radiotherapy or chemotherapy was performed for the other cases.
Myositis ossificans in the infraspinatus muscle: The key to diagnosis
Authors: Stavride Eliza , Bintoudi Antonia , Zagalioti Sofia–Chrysovalantou , Galanis Nikiforos 
Published: September 2019

AbstractThe zone phenomenon is the most important diagnostic feature in differentiating myositis ossificans from malignancies such as osteosarcomas, which calcify from the center to the periphery and its presence in our late‐stage lesion was the key to diagnosis.
Unsolved severe chronic rhinosinusitis elucidated by extensive CFTR genotyping
Authors: Degrugillier Fanny , Simon Stéphanie , Aissat Abdel , Remus Natascha , Mekki Chadia , Decrouy Xavier , Hatton Aurélie , Hinzpeter Alexandre , Hoffmann Brice , Sermet‐Gaudelus Isabelle , Callebaut Isabelle , Fanen Pascale , Prulière‐Escabasse Virginie 
Published: September 2019

AbstractSevere chronic rhinosinusitis in children should alert clinicians and extensive CFTR genotyping should be performed. We propose that thorough clinical and functional assessment in severe chronic rhinosinusitis is valuable to discover rare mutations which could be treated by CFTR correctors to postpone pulmonary infection.
Merkel cell carcinoma mimicking transformed chronic lymphocytic leukemia/small lymphocytic lymphoma
Authors: Bah Ismael , Li Shaoying , Yin C. Cameron , Tang Guilin , Xu Jie 
Published: September 2019

AbstractAlthough MCC has been reported in patients with CLL/SLL, it is extremely rare to observe these two within the same tumor. MCC's positivity for PAX5 and TdT may pose a diagnostic challenge by mimicking transformed CLL/SLL. A thorough workup is critical in reaching the correct diagnosis.
A Compact Gel Membrane Based on a Blend of PEO and PVDF for Dendrite‐Free Lithium Metal Anodes
Authors: Liang Shishuo , Shi Yi , Ma Tianyi , Yan Wenqi , Qin Sainan , Wang Yuqi , Zhu Yusong , Wang Hongwei , Wu Yuping 
Published: September 2019

AbstractA compact gel membrane (GM) with certain flexibility is facilely fabricated after a casted PEO/PVDF blend film is swelled by a LiPF6‐based liquid electrolyte. The GM exhibits a suitable lithium ionic conductivity (0.28 mS cm−1 at r.t., room temperature), a remarkable lithium‐ion transference number (0.52 at r.t.), and high mechanical strength (19.0 MPa) in dry or wet state. Owing to the special comprehensive performance of the GM, dendrite‐free reversible lithium plating/stripping (up to 500 h) at a current density of 0.5 mA cm−2 and a capacity of 0.25 mAh cm−2 is achieved for Li metal anodes at r.t.. The suppression of lithium dendrite of the obtained GM is further demonstrated in Li/GM/LiFePO4 cells with a high discharge capacity (142 mAh g−1 at r.t. and 160 mAh g−1at 50 °C) and a superior cycling stability. This research provides a new strategy for developing lithium metal batteries with high stability and long cycle life.
Electrochemical Approach for the Production of Layered Double Hydroxides with a Well‐Defined Co/MeIII Ratio
Authors: Musella Elisa , Gualandi Isacco , Scavetta Erika , Gazzano Massimo , Rivalta Arianna , Venuti Elisabetta , Christian Meganne , Morandi Vittorio , Tonelli Domenica 
Published: September 2019

AbstractLayered double hydroxides (LDHs) have been widely studied for their plethora of fascinating features and applications. The potentiostatic electrodeposition of LDHs has been extensively applied in the literature as a fast and direct method to substitute classical chemical routes. However, the electrochemical approach does not usually allow for a fine control of the MII/MIII ratio in the synthesized material. By employing a recently proposed potentiodynamic method, LDH films of controlled composition are herein prepared with good reproducibility, using different ratios of the trivalent (Fe or Al) to bivalent (Co) cations in the electrolytic solution. All the obtained materials are shown to be effective oxygen evolution reaction (OER) catalysts, and are thoroughly characterized by a multi‐technique approach, including FE‐SEM, XRD, Raman, AES and a wide range of electrochemical procedures.
Reversible Covalent End‐Capping of Collagen Model Peptides
Authors: Priem Christoph , Geyer Armin 
Published: September 2019

AbstractThe combination of supramolecular aggregation of collagen model peptides with reversible covalent end‐capping of the formed triple helix in a single experimental set‐up yielded minicollagens, which were characterized by a single melting temperature. In spite of the numerous possible reaction intermediates, a specific synthetic collagen with a leading, middle and trailing strand is formed in a highly cooperative self‐assembly process.