bluuebunny/crossref_metadata_2025_split huggingface dataset:
Game Activity and Physiological Responses of Young Tennis Players in a Competition With 2 Consecutive Matches in a Day
Authors: Gallo-Salazar Cesar , Del Coso Juan , Sanz-Rivas David , Fernandez-Fernandez Jaime 
Published: December 2018

Purpose: To determine whether the game activity and physiological responses of young tennis players differed depending on the session of play (eg, morning [MOR] vs afternoon [AFT]) and the final match outcome (eg, winners vs losers) during a simulated competition with 2 matches on the same day. Methods: A total of 12 well-trained male tennis players (age 14.5 [0.8] y) took part in a simulated competition of two 3-set matches separated by 3 h. All the matches were video recorded, and the participants were monitored using 10-Hz global positioning system units including a heart-rate monitor. Effect-size (ES) statistics were used to investigate the magnitudes of the differences. Results: During the AFT matches, in absolute terms, players covered longer total distance (ES = moderate) and ran more distance between 0 and ≤4 m·s−1 (ES = small to large) than in MOR matches. Total duration was also longer (ES = large) in the AFT, where the rest time between rallies was also longer (ES = very large). Heart rate was similar during AFT and MOR matches, but higher rates of perceived exertion (ES = moderate) were reported in the AFT. Only peak running velocity was observed to be likely higher for losers than for winners (ES = small). Conclusions: Game activity and physiological responses of young tennis players differ when 2 consecutive matches are played on the same day. These data might help elucidate the need for specific precompetition training loads and/or between-matches/sessions recovery strategies when facing overloaded competitions.
No Effect of Caffeine Supplementation on Dribbling Speed in Elite Basketball Players
Authors: Scanlan Aaron T. , Dalbo Vincent J. , Conte Daniele , Stojanović Emilija , Stojiljković Nenad , Stanković Ratko , Antić Vladimir , Milanović Zoran 
Published: December 2018

Purpose: To examine the effect of caffeine supplementation on dribbling speed in elite female and male basketball players. Methods: A double-blind, counterbalanced, randomized, crossover design was used. Elite basketball players (N = 21; 10 female, 11 male; age 18.3 [3.3] y) completed placebo (3 mg·kg−1 of body mass of dextrose) and caffeine (3 mg·kg−1 of body mass) trials 1 wk apart during the in-season phase. During each trial, players completed 20-m linear sprints with and without dribbling a basketball. Performance times were recorded at 5-, 10-, and 20-m splits. Dribbling speed was measured using traditional (total performance time) and novel (dribble deficit) methods. Dribble deficit isolates the added time taken to complete a task when dribbling compared with a nondribbling version of the same task. Comparisons between placebo and caffeine conditions were conducted at group and individual levels. Results: Nonsignificant (P > .05), trivial to small (effect size = 0.04–0.42) differences in dribbling speed were observed between conditions. The majority (20 out of 21) of players were classified as nonresponders to caffeine, with 1 player identified as a negative responder using dribble-deficit measures. Conclusions: Results indicate that caffeine offers no ergogenic benefit to dribbling speed in elite basketball players. The negative response to caffeine in 1 player indicates that caffeine supplementation may be detrimental to dribbling speed in specific cases and emphasizes the need for individualized analyses in nutrition-based sport-science research.
The HPAfrica protocol: Assessment of health behaviour and population-based socioeconomic, hygiene behavioural factors - a standardised repeated cross-sectional study in multiple cohorts in sub-Saharan Africa
Authors: Pak Gi Deok , Haselbeck Andrea Haekyung , Seo Hyeong Won , Osei Isaac , Amuasi John , Breiman Robert F , Cruz Espinosa Ligia Maria , Holm Marianne , Im Justin , Jang Geun Hyeog , Jeon Hyon Jin , Luby Stephen P , Lunguya-Metila Octavie , MacWright William , Mogeni Ondari Daniel , Okeke Iruka N , Owusu-Dabo Ellis , Park Jin Kyung , Park Se Eun , Popoola Oluwafemi , Seo Hye Jin , Soura Abdramane Bassiahi , Teferi Mekonnen , Toy Trevor , Chon Yun , Rafindrakalia Mathilde , Rakotozandrindrainy Raphaël , Meyer Christian G , Marks Florian , Panzner Ursula 
Published: December 2018

IntroductionThe objective of the Health Population Africa (HPAfrica) study is to determine health behaviour and population-based factors, including socioeconomic, ethnographic, hygiene and sanitation factors, at sites of the Severe Typhoid Fever in Africa (SETA) programme. SETA aims to investigate healthcare facility-based fever surveillance in Burkina Faso, the Democratic Republic of the Congo, Ethiopia, Ghana, Madagascar and Nigeria. Meaningful disease burden estimates require adjustment for health behaviour patterns, which are assumed to vary among a study population.Methods and analysisFor the minimum sample size of household interviews required, the assumptions of an infinite population, a design effect and age-stratification and sex-stratification are considered. In the absence of a population sampling frame or household list, a spatial approach will be used to generate geographic random points with an Aeronautical Reconnaissance Coverage Geographic Information System tool. Printouts of Google Earth Pro satellite imagery visualise these points. Data of interest will be assessed in different seasons by applying population-weighted stratified sampling. An Android-based application and a web service will be developed for electronic data capturing and synchronisation with the database server in real time. Sampling weights will be computed to adjust for possible differences in selection probabilities. Descriptive data analyses will be performed in order to assess baseline information of each study population and age-stratified and sex-stratified health behaviour. This will allow adjusting disease burden estimates. In addition, multivariate analyses will be applied to look into associations between health behaviour, population-based factors and the disease burden as determined in the SETA study.Ethics and disseminationEthic approvals for this protocol were obtained by the Institutional Review Board of the International Vaccine Institute (No. 2016–0003) and by all collaborating institutions of participating countries. It is anticipated to disseminate findings from this study through publication on a peer-reviewed journal.
Patterns of multiple lifestyle risk factors and their link to mental health in the German adult population: a cross-sectional study
Authors: Atzendorf Josefine , Apfelbacher Christian , Gomes de Matos Elena , Kraus Ludwig , Piontek Daniela 
Published: December 2018

ObjectivesLifestyle risk factors, such as drinking or unhealthy diet, can expotentiate detrimental health effects. Therefore, it is important to investigate multiple lifestyle risk factors instead of single ones. The study aims at: (1) identifying patterns of lifestyle risk factors within the adult general population in Germany and (2) examining associations between the extracted patterns and external factors.DesignCross-sectional study.SettingGeneral German adult population (aged 18–64 years).ParticipantsParticipants of the 2015 Epidemiological Survey of Substance Abuse (n=9204).Primary outcome measuresLifestyle risk factors (daily smoking, at-risk alcohol consumption, unhealthy diet, low physical activity, weekly use of pharmaceuticals, as well as consumption of cannabis and other illicit drugs).ResultsA latent class analysis was applied to identify patterns of lifestyle risk factors, and a multinomial logistic regression was carried out to examine associations between the extracted classes and external factors. A total of four classes were extracted which can be described as healthy lifestyle (58.5%), drinking lifestyle (24.4%), smoking lifestyle (15.4%) and a cumulate risk factors lifestyle (1.7%). Individuals who were male, at younger age and single as well as individuals with various mental health problems were more likely to show multiple lifestyle risk factors.ConclusionsHealthcare professionals should be aware of correlations between different lifestyle risk factors as well as between lifestyle risk groups and mental health. Health promotion strategies should further focus especially on younger and single men.
Randomised placebo-controlled trial of combination ACE inhibitor and beta-blocker therapy to prevent cardiomyopathy in children with Duchenne muscular dystrophy? (DMD Heart Protection Study): a protocol study
Authors: Bourke John P , Watson Gillian , Muntoni Francesco , Spinty Stefan , Roper Helen , Guglieri Michela , Speed Chris , McColl Elaine , Chikermane Ashish , Jayawant Sandeep , Adwani Satish , Willis Tracey , Wilkinson Jennifer , Bryant Andrew , Chadwick Thomas , Wood Ruth , Bushby Kate 
Published: December 2018

IntroductionAlthough cardiologists were ‘late-comers’ to the multidisciplinary team—contributing to the complex care of patients with Duchenne muscular dystrophy (DMD), they now recognise the importance of systematic cardiac surveillance and timely therapy to prolonged survival in patients with DMD. Empirical deployment of cardioactive medications has already improved outcomes, but the evidence base for clinical decision making is weak. Fundamental questions remain as to whether prophylactic therapy is justified and convincingly superior to prompt deployment of the same therapies once left ventricular (LV) dysfunction is detected. Even if it were, at what age should therapy be introduced and with what specific drugs?Methods and analysisWe are conducting a multicentre, parallel group, randomised, placebo-controlled study of combination therapy with an ACE inhibitor (perindopril) and a beta-blocker (bisoprolol) in boys with DMD aged 5–13 years, with normal LV function by echocardiographic criteria at the time of recruitment. Boys are being followed-up for a minimum of 3 years and a maximum of 5 years and undergo repeat assessments of LV function, heart rate and ECG, forced expiratory volume in the 1 s and forced vital capacity, adverse event reporting and quality of life at 6 monthly intervals.The primary outcome is change in LV function between active and placebo-treated participants over the course of the study.Ethics and disseminationThe study was approved by ‘NRES Committee East Midlands – Derby’. The results will be disseminated through manuscript publications, an international workshop and presentations to scientific meetings and parent forums.Translational aspectsThe study seeks to establish the evidence for prophylactic heart therapies for children with DMD, define the optimum age for their introduction and identify any safety concerns.Article summaryThe protocol describes the design of an ongoing multicentre, double-blind, randomised placebo-controlled study to establish the evidence for the use of prophylactic heart therapies in children with DMD, define the optimum age for their introduction and identify any safety concerns.Trial registration numbersEudraCT2007-005932-10 andISRCTN50395346; Pre-results.
Systematic literature review on which maternal alcohol behaviours are related to fetal alcohol spectrum disorders (FASD)
Authors: Roozen Sylvia , Peters Gjalt-Jorn Ygram , Kok Gerjo , Townend David , Nijhuis Jan , Koek Ger , Curfs Leopold 
Published: December 2018

ObjectivesFetal alcohol spectrum disorders (FASD) is a worldwide problem. Maternal alcohol consumption is an important risk factor for FASD. It remains unknown which alcohol consumption patterns most strongly predict FASD. The objective of this study was to identify these.DesignSystematic literature review.MethodsWe searched in PubMed, PsychINFO, PsycARTICLES, ERIC, CINAHL, Embase and MEDLINE up to August 2018. The query consisted of keywords and their synonyms related to FASD, pregnancy and behaviour. Studies were excluded when not published in English, were reviews or involved non-human subjects. Substantial heterogeneity precluded aggregation or meta-analysis of the data. Instead, data were qualitatively inspected.ResultsIn total, 21 studies were eligible for further data analysis. All studies that measured both maternal alcohol drinking behaviours and FASD reported retrospective data on maternal drinking patterns, employing both continuous and categorical measures and exhibiting substantial heterogeneity in measures of alcohol consumption (eg, timing of exposure, quantification of alcohol measure and definition of a standard drink). Study quality improved over time and appeared higher for studies based on active case ascertainment, especially when conducted in schools and when behaviour was assessed through interviews.ConclusionsWe aimed to identify specific maternal drinking behaviour(s) related to FASD. The state of the literature precludes such conclusions. Evidence-based preventive measures necessitate identifying which prenatal alcohol drinking behaviour(s) are most in need of intervention. Therefore, we formulate three recommendations for future research. First, future studies can optimise the value of the collected dataset through specifying measurements and reporting of maternal drinking behaviours and avoiding categorised measures (nominal or ordinal) whenever possible. Second, samples should not be selected based on FASD status, but instead, FASD status as well as maternal alcohol consumption should both be measured in a general population sample. Finally, we provide 10 reporting guidelines for FASD research.
Body composition and physical activity as mediators in the relationship between socioeconomic status and blood pressure in young South African women: a structural equation model analysis
Authors: Munthali Richard J , Manyema Mercy , Said-Mohamed Rihlat , Kagura Juliana , Tollman Stephen , Kahn Kathleen , Gómez-Olivé F Xavier , Micklesfield Lisa K , Dunger David , Norris Shane A 
Published: December 2018

ObjectivesVarying hypertension prevalence across different socioeconomic strata within a population has been well reported. However, the causal factors and pathways across different settings are less clear, especially in sub-Saharan Africa. Therefore, this study aimed to compare blood pressure (BP) levels and investigate the extent to which socioeconomic status (SES) is associated with BP, in rural and urban South Africa women.SettingRural and urban South Africa.DesignCross-sectional.ParticipantsCross-sectional data on SES, total moderate and vigorous physical activity (MVPA), anthropometric and BP were collected on rural (n=509) and urban (n=510) young black women (18–23 years age). Pregnant and mentally or physically disabled women were excluded from the study.ResultsThe prevalence of combined overweight and obesity (46.5% vs 38.8%) and elevated BP (27.0% vs 9.3%) was higher in urban than rural women, respectively. Results from the structural equation modelling showed significant direct positive effects of body mass index (BMI) on systolic BP (SBP) in rural, urban and pooled datasets. Negative direct effects of SES on SBP and positive total effects of SES on SBP were observed in the rural and pooled datasets, respectively. In rural young women, SES had direct positive effects on BMI and was negatively associated with MVPA in urban and pooled analyses. BMI mediated the positive total effects association between SES and SBP in pooled analyses (ß 0.46; 95% CI 0.15 to 0.76).ConclusionsThough South Africa is undergoing nutritional and epidemiological transitions, the prevalence of elevated BP still varies between rural and urban young women. The association between SES and SBP varies considerably in economically diverse populations with BMI being the most significant mediator. There is a need to tailor prevention strategies to take into account optimising BMI when designing strategies to reduce future risk of hypertension in young women.
Efficacy of bisphosphonates in specific knee osteoarthritis subpopulations: protocol for an OA Trial Bank systematic review and individual patient data meta-analysis
Authors: Deveza Leticia A , Bierma-Zeinstra Sita M A , van Spil Willem Evert , Oo Win Min , Saragiotto Bruno T , Neogi Tuhina , van Middelkoop Marienke , Hunter David J 
Published: December 2018

IntroductionRandomised clinical trials to date investigating the efficacy of bisphosphonates in knee osteoarthritis (OA) have found divergent results, with a recent meta-analysis finding no superiority of these drugs over placebo. Whether particular patient subgroups are more likely to benefit from this therapy than others is still unclear. We aim to investigate the effects of bisphosphonates compared with a control group (placebo, no treatment, another active treatment) on clinical and structural outcomes in specific knee OA subpopulations with possible distinct rates of subchondral bone turnover.Methods and analysisMedline, Embase, Scopus, Web of Sciences and Cochrane Central Register of Controlled Trials will be searched from inception to February 2018. Randomised clinical trials will be eligible if they reported at least one potential treatment effect modifier at baseline: gender, menopausal status, age, body mass index, radiographic stage, knee pain severity, presence of bone marrow lesions, levels of biochemical markers of bone turnover (serum and/or urinary) and systemic bone mineral density status. Authors of original trials will be contacted to obtain individual patient data from each study. Risk of bias will be assessed using the Cochrane Collaboration’s tool. The primary outcomes will include pain and radiographic joint space width loss. Studies using other MRI-based assessment of disease progression will also be eligible. Outcomes will be grouped into short-term (≤3 months), intermediate-term (>3 months; ≤12 months) and long-term (>12 months). Regression models will be used, adding an interaction term for each subgroup of interest to determine possible subgroup effects. There was no source of funding for this study.Ethics and disseminationDissemination of our findings is planned to occur through conference presentations, publication in peer-reviewed journals and social media. No formal ethics approval is generally required as no new data collection will be undertaken.PROSPERO registration numberCRD42018093327.
Smoking behaviours of Hong Kong Chinese hospitalised patients and predictors of smoking abstinence after discharge: a cross-sectional study
Authors: Ho Ka Yan , Li William Ho Cheung , Lam Katherine Ka Wai , Wang Man Ping , Xia Wei , Ho Lok Yin , Tan Kathryn Choon Beng , Sin Hubert Kit Man , Cheung Elaine , Mok Maisy Pik Hung , Lam Tai Hing 
Published: December 2018

ObjectivesPatients admitted to hospitals represent an excellent teachable moment for smoking cessation, as they are required to abstain from tobacco use during hospitalisation. Nevertheless, smoking behaviours of hospitalised patients, and factors that lead to smoking abstinence thereafter, remain relatively underexplored, particularly in a Hong Kong Chinese context. This study aimed to examine the smoking behaviours of hospitalised patients and explore factors leading to their abstaining from cigarette use after being hospitalised.DesignA cross-sectional design was employed.SettingThis study was conducted in three outpatient clinics in different regions in Hong Kong.ParticipantsA total of 382 recruited Chinese patients.Primary and secondary outcome measuresThe patients were asked to complete a structured questionnaire that assessed their smoking behaviours before, during and after hospitalisation.ResultsThe results indicated 23.6% of smokers smoked secretly during their hospital stay, and about 76.1% of smokers resumed smoking after discharge. Multivariate logistic regression analysis found that number of days of hospitalisation admission in the preceding year (OR 1.02; 95% CI 1.01 to 1.27; p=0.036), patients’ perceived correlation between smoking and their illness (OR 1.08; 95% CI 1.01 to 1.17; p=0.032), withdrawal symptoms experienced during hospitalisation (OR 0.75; 95% CI 0.58 to 0.97; p=0.027) and smoking cessation support from healthcare professionals (OR 1.18; 95% CI 1.07 to 1.36; p=0.014) were significant predictors of smoking abstinence after discharge.ConclusionsThe results of this study will aid development of appropriate and innovative smoking cessation interventions that can help patients achieve more successful smoking abstinence and less relapse.Trial registration numberNCT02866760.
Factors affecting the acceptability of isoniazid preventive therapy among healthcare providers in selected HIV clinics in Nairobi County, Kenya: a qualitative study
Authors: Wambiya Elvis Omondi Achach , Atela Martin , Eboreime Ejemai , Ibisomi Latifat 
Published: December 2018

ObjectiveDespite being globally recommended as an effective intervention in tuberculosis (TB) prevention among people living with HIV, isoniazid preventive therapy (IPT) implementation remains suboptimal, especially in sub-Saharan Africa. This study explored the factors influencing the acceptability of IPT among healthcare providers in selected HIV clinics in Nairobi County, Kenya, a high HIV/TB burden country.DesignA qualitative study was conducted using in-depth interviews with healthcare providers in selected HIV clinics. All conversations were audio recorded, transcribed verbatim and analysed using a thematic approach.SettingThe study was conducted in the HIV clinics of three purposefully selected public healthcare facilities in Nairobi County, Kenya between February 2017 and April 2017.ParticipantsEighteen purposefully selected healthcare providers (clinicians, nurses, pharmacists and counsellors) working in the HIV clinics participated in the study.ResultsProvider acceptability of IPT was influenced by factors relating to the organisational context, provider training on IPT and their perception on its efficacy, length and clarity of IPT guidelines and standard operation procedures, as well as structural factors (policy, physical and work environment). Inadequate high-level commitment and support for the IPT programme by programme managers and policy-makers were found to be the major barriers to successful IPT implementation in our study context.ConclusionThis study provides insight into the complexity of factors affecting the IPT implementation in Kenya. Ensuring optimal acceptability of IPT among healthcare providers will require an expanded depth of engagement by policy-makers and IPT programme managers with both providers and patients, as well as on-the-job design specific actions to support providers in implementation. Such high-level commitment and support are consequently essential for quality delivery of the intervention.