bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monosomal karyotypes apart from complex karyotypes independently predict the outcome of myelodysplastic syndrome patients using a fluorescence in situ hybridization panel and conventional cytogenetics
Authors: Wang Na , Xu Hongzhi , Li Qing , Liu Jie , Sui Xiaohui , Jiang Yujie , Fang Xiaosheng , Zhen Changqing , Ding Mei , Yuan Dai , Zhang Lingyan , Wang Xin 
Published: May 2019

AbstractIntroductionThe aim of the study was to analyze monosomal karyotype (MK) occurrence and the relationship between MKs and complex karyotypes (CKs) and to determine the prognostic significance of MKs in MDS patients based on conventional cytogenetic (CC) and fluorescence in situ hybridization (FISH) analyses.MethodsCC and FISH analyses were conducted for 216 primary MDS patients. Follow‐ups and statistical analysis were conducted.ResultsA total of 25 (11.6%) patients with MKs were identified by FISH and CC analyses, and 23 (92%) of these MKs were also CKs. Only 19 patients (8.8%) with MKs were identified by CC analysis. Patients with MKs had higher bone marrow (BM) blast counts (P = 0.006), incidence of very high risk according to International Prognostic Scoring System‐Revised (IPSS‐R) (P < 0.001), leukemic transformation (P = 0.003,) and death rates (P < 0.001) than those without MKs. Overall survival (OS) and progression‐free survival (PFS) of MK or CK patients which were additionally detected by FISH and CC analyses had no statistical significance with those MK or CK patients detected by CC analyses separately. Multivariate analysis indicated that MK (P < 0.001), blast in BM (P < 0.001) and age (P = 0.028) were inferior independent prognostic factors in OS, whereas CK (P = 0.003) was the inferior independent prognostic factor in PFS.ConclusionThe MDS FISH panel may provide additional information for defining MKs beyond CC analysis. MK was an important indicator of OS in MDS patients, and CK indicated inferior disease progression but did not influence OS according to CC and FISH analyses.
Evolution of the neural sex‐determination system in insects: does fruitless homologue regulate neural sexual dimorphism in basal insects?
Authors: Watanabe T. 
Published: May 2019

AbstractIn the brain of holometabolous insects such as the fruit fly Drosophila melanogaster, the fruitless gene produces sex‐specific gene products under the control of the sex‐specific splicing cascade and contributes to the formation of the sexually dimorphic circuits. Similar sex‐specific gene products of fruitless homologues have been identified in other holometabolous insects such as mosquitoes and a parasitic wasp, suggesting the fruitless‐dependent neural sex‐determination system is widely conserved amongst holometabolous insects. However, it remains obscure whether the fruitless‐dependent neural sex‐determination system is present in basal hemimetabolous insects. To address this issue, identification, characterization, and expression analyses of the fruitless homologue were conducted in the two‐spotted cricket, Gryllus bimaculatus, as a model hemimetabolous insect. The Gryllus fruitless gene encodes multiple isoforms with a unique zinc finger domain, and does not encode a sex‐specific gene product. The Gryllus Fruitless protein is broadly expressed in the neurones and glial cells in the brain, and there was no prominent sex‐related difference in the expression levels of Gryllus fruitless isoforms. The results suggest that the Gryllus fruitless gene is not involved in the neural sex‐determination in the cricket brain.
The role of prosody in infants’ preference for speech: A comparison between speech and birdsong
Authors: Santolin Chiara , Russo Sofia , Calignano Giulia , Saffran Jenny R. , Valenza Eloisa 
Published: May 2019

AbstractSpeech preferences emerge very early in infancy, pointing to a special status for speech in auditory processing and a crucial role of prosody in driving infant preferences. Recent theoretical models suggest that infant auditory perception may initially encompass a broad range of human and nonhuman vocalizations, then tune in to relevant sounds for the acquisition of species‐specific communication sounds. However, little is known about sound properties eliciting infants’ tuning‐in to speech. To address this issue, we presented a group of 4‐month‐olds with segments of non‐native speech (Mandarin Chinese) and birdsong, a nonhuman vocalization that shares some prosodic components with speech. A second group of infants was presented with the same segment of birdsong paired with Mandarin played in reverse. Infants showed an overall preference for birdsong over non‐native speech. Moreover, infants in the Backward condition preferred birdsong over backward speech whereas infants in the Forward condition did not show clear preference. These results confirm the prominent role of prosody in early auditory processing and suggest that infants’ preferences may privilege communicative vocalizations featured by certain prosodic dimensions regardless of the biological source of the sound, human or nonhuman.
Computational insights into the structure of barium titanosilicate glasses
Authors: Ghardi El Mehdi , Atila Achraf , Badawi Michael , Hasnaoui Abdellatif , Ouaskit Said 
Published: May 2019

AbstractUnderstanding the role of TiO2 in BaO‐TiO2‐SiO2 (BTS) glasses is one of the keys to develop new glasses and glass‐ceramics for different technological applications. For the first time, molecular dynamics simulations were conducted to get new insights into the atomic structure of the BTS glasses and their elastic moduli. Various compositions are studied where SiO2 have been replaced by TiO2. The calculated mechanical properties of our models are observed to depend linearly on TiO2 content. However, the structure‐induced changes are far from such dependence. The structural results indicate that BTS glasses are mainly built on four types of basic units: SiO4, TiO4, TiO5 and TiO6. This high structural heterogeneity induced by the three coordination states of Ti is found to have an impact on the medium range order by increasing the rings number, the polymerized regions, and by transforming Q3‐Q4 and Q2 without neglecting the increase in Q5 and Q6 species. Those structural modifications of the BTS glass network features have been found to be consistent with available experimental data.
Coexistence mechanism of Eu2+/Eu3+ ions in YAl3(BO3)4: Crystal structure, luminescence property, and substitution defects
Authors: Liu Jinjin , Wang Zhijun , Li Xue , Bao Qi , Meng Xiangyu , Qiu Keliang , Lai Weidong , Yang Zhiping , Li Panlai 
Published: May 2019

AbstractThe coexistence mechanism of Eu2+ and Eu3+ ions in YAl3(BO3)4 host under different reducing conditions is investigated and confirmed in great detail, which can be described by three aspects as following. First, Eu3+ is protected by the layered structure of YAl3(BO3)4. Second, the number of the interstitial defects ((Al)i…,(Y)i…) increases with increasing Eu2+ to maintain the charge balance of the system. And these defects can capture free electrons which are used for the reduction of Eu3+. Finally, free holes become more and more with the number of nonequivalent substitution defects (EuY') increasing, which make the 5d electrons of Eu2+easily escape to the conduction band and Eu2+ convert to Eu3+. This work will be of great significance to research coexistence of multiple valence ions in the structure of borate and defect motion with nonequivalent substitution.
A qualitative analysis of the experience of staff employed within the forensic disability sector in Victoria, Australia
Authors: Coates Bethany , Jones Tim 
Published: May 2019

AbstractBackgroundThis paper explores the experience of staff employed within forensic disability across Victoria in an attempt to better understand service needs in this field. The complex needs of individuals with disabilities involved in the criminal justice system or presenting with offence‐related behaviours suggest that there is a requirement to improve services directed towards forensic disability.MethodsFour semi‐structured group interviews, determined by geographical location, were completed with employees (n = 14) within the Australian Community Support Organisation, with an average of 5 years of forensic disability experience. Data were analysed based on thematic analysis.ResultsFive themes were revealed. Three pre‐existing themes were emphasized that included client complexity; poor responses from external services; and funding, and two novel themes labelled as staff well‐being and responses to risk.ConclusionsRecommendations include multiagency collaboration, funding forensic disability services, development of best practice initiatives and advocacy.
Network and pathway‐based analysis of microRNA role in neuropathic pain in rat models
Authors: Guo Jia‐Bao , Zhu Yi , Chen Bing‐Lin , Song Ge , Peng Meng‐Si , Hu Hao‐Yu , Zheng Yi‐Li , Chen Chang‐Cheng , Yang Jing‐Zhao , Chen Pei‐Jie , Wang Xue‐Qiang 
Published: May 2019

AbstractThe molecular mechanisms underlying neuropathic pain (NP) remain poorly understood. Emerging evidence has suggested the role of microRNAs (miRNAs) in the initiation and development of NP, but the specific effects of miRNAs in NP are largely unknown. Here, we use network‐ and pathway‐based methods to investigate NP‐induced miRNA changes and their biological functions by conducting a systematic search through multiple electronic databases. Thirty‐seven articles meet the inclusion criteria. Venn analysis and target gene forecasting are performed and the results indicate that 167 overlapping target genes are co‐regulated by five down‐regulated miRNAs (rno‐miR‐183, rno‐miR‐96, rno‐miR‐30b, rno‐miR‐150 and rno‐miR‐206). Protein‐protein interaction network analysis shows that 77 genes exhibit interactions, with cyclic adenosine monophosphate (cAMP)‐dependent protein kinase catalytic subunit beta (degree = 11) and cAMP‐response element binding protein 1 (degree = 10) having the highest connectivity degree. Gene ontology analysis shows that these target genes are enriched in neuron part, neuron projection, somatodendritic compartment and nervous system development. Moreover, analysis of Kyoto Encyclopedia of Genes and Genomes reveals that three pathways, namely, axon guidance, circadian entrainment and insulin secretion, are significantly enriched. In addition, rno‐miR‐183, rno‐miR‐96, rno‐miR‐30b, rno‐miR‐150 and rno‐miR‐206 are consistently down‐regulated in the NP models, thus constituting the potential biomarkers of this disease. Characterizing these miRNAs and their target genes paves way for their future use in clinical practice.
Racial Disparities in Readmission Rates among Patients Discharged to Skilled Nursing Facilities
Authors: Rivera‐Hernandez Maricruz , Rahman Momotazur , Mor Vincent , Trivedi Amal N. 
Published: May 2019

OBJECTIVESPrior studies have reported mixed findings about the existence of racial disparities in readmission rates among Medicare Advantage beneficiaries, but these studies used data from one state, focused on black‐white disparities, and did not focus on patients discharged to skilled nursing facilities (SNFs). The objective of the study was to characterize racial and ethnic disparities in rates of 30‐day rehospitalization directly from SNFs among fee‐for‐service and Medicare Advantage patients.DESIGNA cross‐sectional study of admissions to SNFs in 2015 was conducted.SETTINGSNFs across the United States.PARTICIPANTSThe sample included 1 500 334 white, 213 848 African American, and 99 781 Hispanic Medicare patients who were admitted to 13 375 SNFs.MEASUREMENTSThe main outcome of interest was readmission, identified as patients sent back to any hospital directly from the SNF within 30 days of admission, as indicated on the Minimum Data Set discharge assessment.RESULTSOverall readmission rates for fee‐for‐service patients were 16.7% (95% confidence interval [CI] = 16.7%‐16.8%) for whites, 18.8% (95% CI = 18.7%‐19.0%) for African Americans, and 17.4% (95% CI = 17.1%‐17.7%) for Hispanics. Readmission rates in Medicare Advantage were 14.7% (95% CI = 14.5%‐14.8%) for whites, 16.8% (95% CI = 16.6%‐17.1%) for African Americans, and 15.3% (95% CI = 14.9%‐15.6%) for Hispanics. We also found that African Americans had about 1% higher readmission rates than whites, even when they received care within the same SNF. No statistically significant differences were found in the magnitude of within‐SNF racial disparities in Medicare Advantage compared with Medicare fee‐for‐service.CONCLUSIONWe found racial disparities in readmission rates even within the same facility for both Medicare Advantage and fee‐for‐service beneficiaries. Intervention to reduce disparities in readmission rates, as well as more comprehensive quality measures that incorporate outcomes for Medicare Advantage enrollees, are needed. J Am Geriatr Soc 67:1672–1679, 2019
Person‐Centered Primary Care and Type 2 Diabetes: Beyond Blood Glucose Control
Authors: Trout Kimberly K. , McCool William F. , Homko Carol J. 
Published: May 2019

AbstractWith an estimated 9% of persons in the United States diagnosed with diabetes, primary care providers such as midwives and nurse practitioners are increasingly working with persons who have diabetes and are seeking primary care services. This article reviews the current literature with regard to the initial evaluation of individuals who are diagnosed with diabetes, and what is entailed in comprehensive continuing management of care. A person‐centered interprofessional approach to care of the person with diabetes is presented. Recommendations are given that address dietary habits, activities of daily living, medication regimens, and potential alternative therapies. Social constructs related to effective care of individuals with diabetes also are addressed. Knowledge of current research that has identified effective care practices for individuals with diabetes is imperative to ensuring their well‐being, and promoting a person‐centered and interprofessional approach is best for offering optimal care to those diagnosed with diabetes.
Glyphosate and glyphosate‐based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome
Authors: Dechartres Julie , Pawluski Jodi L. , Gueguen Marie‐Madeleine , Jablaoui Amin , Maguin Emmanuelle , Rhimi Moez , Charlier Thierry D. 
Published: May 2019

AbstractGlyphosate is found in a large array of non‐selective herbicides such as Roundup® (Monsanto, Creve Coeur, MO, USA) and is by far the most widely used herbicide. Recent work in rodent models suggests that glyphosate‐based herbicides during development can affect neuronal communication and result in altered behaviours, albeit through undefined mechanisms of action. To our knowledge, no study has investigated the effects glyphosate or its formulation in herbicide on maternal behaviour and physiology. In the present study, relatively low doses of glyphosate (5 mg kg‐1 d‐1), Roundup® (5 mg kg‐1 d‐1 glyphosate equivalent), or vehicle were administered by ingestion to Sprague‐Dawley rats from gestational day (GD) 10 to postpartum day (PD)22. The treatments significantly altered licking behaviour toward pups between PD2 and PD6. We also show in the dams at PD22 that Roundup exposure affected the maturation of doublecortin‐immunoreactive new neurones in the dorsal dentate gyrus of the hippocampus of the mother. In addition, the expression of synaptophysin was up‐regulated by glyphosate in the dorsal and ventral dentate gyrus and CA3 regions of the hippocampus, and down‐regulated in the cingulate gyrus. Although a direct effect of glyphosate alone or its formulation on the central nervous system is currently not clear, we show that gut microbiota is significantly altered by the exposure to the pesticides, with significant alteration of the phyla Bacteroidetes and Firmicutes. This is the first study to provide evidence that glyphosate alone or in formulation (Roundup) differentially affects maternal behaviour and modulates neuroplasticity and gut microbiota in the mother.
Excellent response to mesotherapy as adjunctive treatment in male androgenetic alopecia
Authors: Melo Daniel Fernandes , de Mattos Barreto Taynara , Plata Glaura Tinoco , Araujo Leonardo Rotolo , Tortelly Violeta Duarte 
Published: May 2019

AbstractAndrogenetic alopecia (AGA) is the most common type of alopecia. Currently, only topical minoxidil and oral finasteride, for men, are approved for its treatment. We report a case of a patient with male pattern AGA treated with topical minoxidil and oral finasteride for 2 years, with partial improvement. At this point, we added mesotherapy to the previous treatment. The patient had 20 sessions of sterile mesotherapy blend, containing minoxidil, finasteride, biotin, and D‐panthenol. We did the injections every two weeks and made the response assessment with global clinical photographs at the 10th and the 20th sessions when we noted a significant visible improvement in hair density and thickness. Mesotherapy or intradermotherapy is defined as a technique that involves the use of multiple intradermal injections of a mixture of compounds in low doses, at many points, near/over the affected sites. In our case, the patient had an excellent response to intradermotherapy as an adjunctive treatment, with no side effects. Although we still need additional clinical trials to standardize the therapy and treatment guidelines, mesotherapy seems to be a therapeutic option in the treatment of AGA, especially if the procedure happens in a medical facility, with correct indication and adequate execution of this promising technique.
A comparison of the efficacy and tolerability of topical agents used in facial Demodex treatment
Authors: Sarac Gulbahar 
Published: May 2019

AbstractBackgroundDemodex spp. is the most common ectoparasite in humans. This parasite is believed to play a role in the etiology of many dermatological and ocular disorders.AimThe aim of this study was to compare the efficacy and tolerability of the sulfur‐sodium sulfacetamide combination, crotamiton, and permethrin, which are three topical agents commonly used in Demodex treatment.MethodsA total of 28 patients with primary demodicosis and 44 patients with Rosacea + Demodex were included in the study. The pretreatment and post‐treatment Demodex spp. counts, patient satisfaction, and erythema decrease rates were compared.ResultsAnalysis of the efficacy of these topical agents on Demodex revealed that all three significantly decreased the number of parasites. The patient satisfaction was higher in the sodium acetamide group than the 10% crotamiton and 5% permethrin groups, and clinical evaluation (erythema/ papulopustules and white plugs) was better in the sodium acetamide group than the other groups but no statistically significant difference was found in terms of patient satisfaction and clinical evaluation.ConclusionThe sulfur‐sodium combination, crotamiton, and permethrin are the three agents commonly used in the treatment of Demodex spp. and all significantly decreased the Demodex count. The three agents were similar in terms of tolerability. Our study needs to be supported with others on larger patient series.
Perspective: State‐of‐the‐Art: The Quality of Case Study Research in Innovation Management
Authors: Goffin Keith , Åhlström Pär , Bianchi Mattia , Richtnér Anders 
Published: May 2019

The practice of innovation management is developing fast. As new concepts emerge, exploratory studies are needed and case study research is often appropriate. To investigate the usage and quality of case study research in innovation management, all of the articles published in five top journals over 20 years (1997–2016) were reviewed. Case study research accounted for 818 of the published articles in this period (12%) and an evaluation template (termed case study evaluation template: CASET) was developed to objectively assess these articles against 10 quality criteria. It was found that the quality of case study research has often been low, although it has improved over time. Similarly, quality was found to fluctuate both within and between the different innovation journals. This indicates that the peer review process for case study research is not as robust as it should be. The assessment of individual articles using the evaluation template found significant deficiencies. Many articles: did not justify why case study research was appropriate; did not apply theoretical sampling criteria; were not transparent on how conclusions were drawn from the data; did not consider validity and reliability adequately; and did not go beyond description in their interpretation. However, the evaluation template also identified 23 “exemplary studies,” which clearly addressed nearly every criterion. Such exemplary studies provide innovation management researchers with “benchmark” reading, which can help shape their own research. This article makes four contributions to the innovation management discipline. First, the evaluation template and exemplary studies can help innovation researchers improve the quality of their case study research. Second, clear recommendations are given for how reviewers can use the template to make the peer review process more consistent and robust. Third, journal editors are encouraged to consider the implications of the findings for their particular journal. Fourth, the article should stimulate a long overdue debate on methodology in innovation management research, including the use of case study research.
Translating Research Findings in Genetics of Learning Disabilities to Special Education Instruction
Authors: Erbeli Florina 
Published: May 2019

ABSTRACTGiven a shift in the role of genetics in the context of special education, this commentary outlines advances in our understanding of genetic influences on learning disabilities. In particular, it focuses on advances that have implications for instruction and interventions conducted by special educators, and calls for broadening of the scope of professional preparation of special educators to include research findings in genetic underpinnings of learning disabilities.
Facial manifestation of cowpox: case report
Authors: Madahar G. , Prabhu K. , Davies H.T. 
Published: May 2019

AbstractCowpox is an extremely rare viral condition with fewer than 150 cases being reported. The name Cowpox is somewhat deceptive as it generally tends to not be enzootic within cattle. The clinical appearance may present similar to other common cutaneous lesions. Here, we present a peculiar case of cowpox affecting the mental region of a young fit and well 8‐year‐old boy. The objective of this case report is to enlighten the audience with regard to reviewing the special investigations required in order to correctly diagnose this condition.
Evaluating depression in cognitively healthy elderly people by using Mini‐Mental State Examination
Authors: Murayama Norio , Ota Kazumi , Matsunaga Yusuke , Ichikura Kanako , Fukase Yuko , Tagaya Hirokuni , Iseki Eizo , Sato Kiyoshi 
Published: May 2019

AimWe examined a method for evaluating depression with the Mini‐Mental State Examination in cognitively healthy elderly people and employed the projective perspective.MethodsIn MMSE three groups—normal, depressed tendency, and depressed—completed the Mini‐Mental State Examination (MMSE) and a Japanese version of the 15‐item Geriatric Depression Scale. The Mini‐Mental State Examination evaluated individuals’ writing based on a sentence, the number of written words, and sentence content; it also assessed their copying of drawn figures.ResultsIn the depressed group, the proportion corresponding to the characteristics of (i) to (iii) was higher than in the other two groups: (i) the calculation score was 0 or 1; (ii) subjects scored above the median in sentence writing relative to similar subjects with the same language and clinical setting; and (iii) subjects expressed feelings in their writing. One point was given for each characteristic, and we calculated the sum. Depressed subjects had a score ≥2.ConclusionsThis evaluation method can differentiate depressed subjects with high accuracy (sensitivity: 77.8%, specificity: 76.4%) without placing an extra burden on the subjects.