bluuebunny/crossref_metadata_2025_split huggingface dataset:
Superoxide Release in Human Fibroblasts upon Treatment with Culture Supernatants of the Arthritogenic Bacteria Erysipelothrix rhusiopathiae and Mycoplasma arthritidis
Authors: Meier Beate 
Published: August 2018

Abstract
Culture supernatants of the arthritogenic bacteria Mycoplasma pneum onia, Mycoplasma arthritidis, Borrelia burgdorferi and Erysipelothrix rhusiopathiae stimulated primary cultures of human fibroblasts to release reactive oxygen species into the environment, whereas cell walls and membranes of these bacteria had no effects. Lipopolysaccharides of various gramnegative bacteria and lipid A , the lipid moiety of endotoxines, also failed to stimulate the release of reactive oxygen species by fibroblasts. The stimulatory fractions of the culture supernatants of Mycoplasma arthritidis and Erysipelothrix rhusiopathiae exhibited a molecular weight of about 9.5 kDa. After an induction period of 5 min the presence of the stimulant was not necessary any more. The primary radical released by the fibroblasts was the superoxide anion O2
-. Radical formation took place continuously over some hours. Additionally, low-level chemiluminescence of fibroblasts was increased upon stimulation with culture supernatants of Mycoplasma arthritidis and Erysipelothrix rhusiopathiae. No irreversible injury of the fibroblast was caused upon stimulation and the cells exhibited normal proliferation pattern after replacing them to the culture medium.
Corrugatin, a Lipopeptide Siderophore from Pseudomonas corrugata
Authors: Risse D. , Beiderbeck H. , Taraz K. , Budzikiewicz H. , Gustine D. 
Published: August 2018

Abstract
From the culture medium of the phytopathogenic bacterium Pseudomonas corrugata, a lipopeptide siderophore was isolated that comprises interesting structural elements such as cyclic condensation products of the two amino groups of 2,4-diamino butyric acid with the carboxyl group of a second amino acid, and the rarely encountered L-threo-β-hydroxy histidine.
Contribution of a Peroxide Adduct of Copper(II)-Peptide Complex to Modify the Secondary Structure of Albumin
Authors: Ishikawa Yoshihiro , Ito Sayo , Nishino Satsohi , Ohba Shigeru , Nishida Yuzo 
Published: August 2018

Abstract
Copper(II)-peroxide Adduct, Modification of Protein, Copper(II)-peptide Complex We have found that copper(II) compounds containing a peptide group in the chelate exhibit high activity for modification or degradation of albumin in the presence of hydrogen peroxide, whereas no activity was detected for the copper(II) compounds without an amide-group. It is suggested that presence of the amide-group in the ligand may play an important role in the formation of a peroxide adduct and in activation of the peroxide ion, leading to cleavage of the peptide bond of a neighboring protein. It is implied that conversion of normal cellular prion protein PrPC into a disease-causing isoform, PrPSc is attributed to the activated peroxide ion coordinated to a copper(II) captured in the NH2-terminal domain of the PrPC .
Sensory Ecology and Neural Coding in Arthropods
Authors: Egelhaaf Martin , Kern Roland , Warzecha Anne-Kathrin 
Published: August 2018

Abstract
Arthropods live in almost any conceivable habitat. Accordingly, structural and functional specialisations have been described in many species which allow them to behave in an adap­tive way with the limited computational resources of their small brains. These adaptations range from the special design of the eyes, the spectral sensitivities of their photoreceptors to the specific properties of neural circuits.
Emergence of Spatio-Temporal Patterns in Neuronal Activity
Authors: Haalman Iris , Vaadia Eilon 
Published: August 2018

Abstract
Neuronal Activity, Emergence of Spatio-Temporal Patterns This paper explores if dynamic modulation of coherent firing serves cortical functions. We recorded neuronal activity in the frontal cortex of behaving monkeys and found that tempo­ ral coincidences of spikes firing of different neurons can emerge within a fraction of a second in relation to the animal behavior. The temporal patterns of the correlation could not be predicted from the modulations of the neurons firing rate and finally, the patterns of correla­ tion depend on the distance between neurons. These findings call for a revision of prevailing models of neural coding that solely rely on firing rates. The findings suggest that modification of neuronal interactions can serve as a mechanism by which neurons associate rapidly into a functional group in order to perform a specific computational task. Increased correlation between members of the groups, and decreased or negative correlation with others, enhance the ability to dissociate one group from concurrently activated competing groups. Such modu­ lation of neuronal interactions allows each neuron to become a member of several different groups and participate in different computational tasks.
Structure Activity Relationships of Antiproliferative Rocaglamide Derivatives from Aglaia Species (Meliaceae)
Authors: Bohnenstengel Frank I. , Steube Klaus G. , Meyer Corinna , Nugroho Bambang W. , Hung Pham D. , Kiet Le C. , Proksch Peter 
Published: August 2018

Eleven rocaglamide derivatives (cyclopentatetrahydrobenzofurans) and one structurally related aglain congener all isolated from different Aglaia species (Meliaceae) were tested for growth inhibiting properties using the human cancer cell lines MONO-MAC-6 and MEL-JUSO. Proliferation of both cell lines was efficiently inhibited in a dose and compound dependent manner. Applying a MTT-Assay, the IC50 of the most active compound didesmethyl-rocaglamide (1) was observed at 0.002 and 0.006 μg/ml (0.004 and 0.013 μM) depending on the cell line investigated. Bulky aminoacyl substituents at C-2, acetylation of the OH substituent at C-1 or insertion of a OH or OMe substituent at C-3 ’of the rocaglamide skeleton all diminished the activity of the compounds investigated. The aglain derivative 12 was inactive up to a concentration of 3 μg/ml (4.6 μᴍ) . This loss of activity is assumed to be mainly due to the presence of a pyran ring in the aglains vs. a furan ring as found in rocaglamide derivatives. Rocaglamide derivatives may act primarily by inhibition of cell proliferation as evidenced by the absence of a significant cytotoxic effect in long-term cultures of MONO-MAC-6 cells treated with high doses of didesmethylrocaglamide.
Our data suggest that rocaglamide derivatives could exert a potential role in the treatment of malignant diseases and are worth to be investigated in further studies of experimental medicine and pharmacology
Light Scattering in the Eye Lens Near the Spinodal
Authors: Grzegorzewski Bronisław , Rudeichuk Volodymyr 
Published: August 2018

Abstract
Scattered light intensities measurements of the nuclear part of adult bovine lenses are reported. In the investigated samples the existence of a binary liquid phase separation from a metastable state is demonstrated by the phenomenon of hysteresis. Fluctuations near spino­dal are studied by means of a tentative theoretical approach. Accordingly the scattered light intensities were analyzed reduced by the intensity obtained for the stable state of the system. Fluctuations in the stable state are ascribed to protein aggregates and are analyzed by means of random density fluctuation theory. To evaluate the correlation length of the fluctuations near spinodal the Ornstein-Zernike theory is adopted. Temperature dependence of the corre­lation length ξ of the fluctuations near spinodal can be described by equation for critical fluctuations

. For the investigated lenses the exponent ν varies from 0.65 to 0.74 and the parameter ξ0 varies from 1.6 nm to 3.6 nm. The spinodal temperature Ts for the investigated samples is evaluated.
Chemo-Enzymatic Syntheses of Both Enantiomers of Neodictyoprolenol and Neodictyoprolene; Possible Biosynthetic Intermediates of Sex Pheromones in Brown Algae
Authors: Yamamoto Yuuko , Akakabe Yoshihiko , Matsui Kenji , Shimidzu Hiroshi , Kajiwara Tadahiko 
Published: August 2018

Neodictyoprolenol [(-)-(S)-(1,5Z,8Z)-undecatrien-3-ol], dictyoprolenol [(-)-(S )-(1,5Z)- undecadien-3-ol] and their acetates neodictyoprolene [(+)-(5)-3-acetoxy-(1,5Z,8Z)-undecatriene] and dictyoprolene [(+)-(S)-3-acetoxy-(1,5Z)-undecadiene], which are interesting as possible biosynthetic intermediates of the sex pheromones (dictyopterene B, C′ and D′) of brown algae, were synthesized by chemo-enzymatic methods through optical resolution of racemic neodictyoprolenol and dictyoprolenol using two lipases; Amano PS (Pseudom onas sp.) and Novozym 435® (Candida sp.). A combination of acylation of the alcohols and hydrolysis of the acetates by Novozym 435® produced neodictyoprolenol, neodictyoprolene, dictyoprolenol and dictyoprolene with high optical purities over 99% enantiomeric excess (e.e.).
This snythetic methods will make it easier to search these compounds in marine algae and to study their biosynthesis.
Hydration of Alkylammonium Salt Micelles - Influence of Bromide and Chloride Counterions
Authors: Róźycka-Roszak Boźenna , Żyłka Romuald , Sarapuk Janusz 
Published: August 2018

The micellization process of dodecyltrimethylammonium chloride (DTAC) and bromide (DTAB) was studied. Nuclear magnetic resonance method was used. The 1H NM R and 13C NM R spectra were taken at higher and lower concentrations than the critical micelle concentrations (CMC) of the compounds studied. Chemical shifts were analysed. The studies performed were prompted by earlier calorimetric measurements which showed that there were significant qualitative and quantitative differences in the micellization process of the compounds studied. Namely, DTAB micelle dissociation was found to be an endothermic process while that of DTAC was exothermic. The differences found must be the result of differentiated influence of bromide and chloride counterions on the micellization process, including the phenomenon of micelle hydration. The objective of the work was to check whether cationic surfactant counterions can influence the micelle hydration process. Indeed, DTAB and DTAC, as monomers, exhibit similar hydrophobic hydration, but DTAB micelles are more hydrated than DTAC ones.
It seems that the differences found in micellization of both salts studied may be attributed to different physicochemical properties of bromide and chloride ions, such as their mobilities and radii of their hydrated forms. Moreover, the effect of anions on the water structure must be taken into account. It is important whether the anions can be classified as water ordering kosmotropes, that hold the first hydration shell tightly, or water disordering chaotropes, that hold water molecules in that shell loosely.
Expression of an HSP110 Family, Ischemia-Responsive Protein (irp94), in the Rat Brain after Transient Forebrain Ischemia
Authors: Koh Hyeon-Song , Moon Il Soo , Lee Young-Ho , Shong Minho , Kwon O-Yu 
Published: August 2018

The transcriptional expression of an ischemia responsive protein (irp94) in the hippocampus of rats was analyzed by Northern blotting. A transient forebrain ischemia was induced in the rats by temporary occluding of the bilateral common carotid arteries (CCAs) for various periods, and then reperfusion. Among the frontal, parietal, temporal and occipital lobes, and the cerebellum and hippocampus, the maximum mRNA expression of irp94 was at the occipital lobe, and the minimum was at the parietal lobe following ten min of forebrain ischemia. The irp94 mRNA expression reached a maximum fifteen min after the transient ischemia. From twenty min on after the ischemia its expression decreased. After a ten-min ischemia and the following reperfusion, irp94 mRNA expression gradually increased in the first twelveh, and then decreased. The expression pattern was like that of the endoplasmic reticulum chaperone, Erp72, but not that of the cytosol chaperone, hsp72. In addition, when intracellular ATP was depleted with antimycin A the mRNA level of irp94 increased in a thyrocyte cell culture model.
The results suggest that irp94, like a molecular chaperone, may play a role in protecting the cell against external stimulation, especially after a transient forebrain ischemia. Although future studies of irp94 will be required to clarify the interactions with other intracellular factors inducing ischemia or showing molecular chaperone activity, what is offered here is an insight into its functional role as a component of stress response in neurons that should be considered as a new therapeutic approach for the treatment of ischemia.
Puelles Romero, Luis (2017) Imágenes sin mundo. Modernidad y extrañamiento, Abada Editores, Serie Estética, Madrid, 230 páginas.
Authors: Maillo Palma Laura 
Published: August 2018

Durante esta sucesión de páginas, exquisitamente escritas y pensadas, tiene lugar una aparición: la “imagen-fantasma” se nos presenta, con toda su potencia, camuflada entre rasgos familiares que, sin embargo, nos alejan de una realidad reconocida y reconocible. Como una pieza perdida o sustraída de un conjunto mayor, con el que ya no podría volver a encajar. Esta imagen espectral, también llamada “simulacro”, acomete una rebelión contra las exigencias que históricamente se habían impuesto sobre el arte visual en el mundo occidental.Extrañamiento, modernidad, imagen, Estética.
The Assessment of the Education Laboratory Performance by Using Balanced Score Card Method
Authors: Nurhasnah Nurhasnah , Eliza Rivdya 
Published: August 2018

This Research was conducted to measure the performance quality of the educational laboratories at the faculty of Islamic Education and Teacher Training in State Islamic University or UIN Imam Bonjol Padang, especially in the performance of the field Practice for Teacher Training laboratory (PPL), Computer and Islamic Education Practice Laboratory (PPAI) by using balanced score card method. In term of the method, four perspectives were used such as: financial perspective, customers (the users) perspective, internal business perspective, and growth and learning process. The foci of this study included: PPL, computer, and PPAI. The subjects of this research were 3 heads of the labors, 6 laboratory staff, 3 financial staff, and 90 students who were studying in semester VII at faculty of Islamic Education and Teacher Training in UIN IB Padang at academic year 2016/2017. Questionnaire, interview guide, and observation sheet were used as the instruments that have been tested their reliability and validity. Data analysis was employed by measuring the customer perspective questionnaires, internal business process perspective, and learning growth perspective. The finding of the study ­­showed that the performance of labor the PPL laboratory is 3.27 (65.35%) with good category. The Performance of computer laboratory is 3.05 (61%) with good category. The Performance of the PPAI laboratory was 2.76 (55.2%) with less good category. Overall, all three laboratory have 3.03 (60.6%) performance measurement result with good category.
Role of Family Obligation Stress on Ugandan Women's Participation in Preventive Breast Health
Authors: Scheel John R. , Parker Scott , Hippe Daniel S. , Patrick Donald L. , Nakigudde Gertrude , Anderson Benjamin O. , Gralow Julie R. , Thompson Beti , Molina Yamile 
Published: August 2018

Abstract

Background
The purpose of this study is to determine the role of family obligation stress on Ugandan women's participation in preventive breast health through the receipt of breast cancer education and health check-ups.

Materials and Methods
A validated survey was conducted on a community sample of Ugandan women, providing a multi-item scale to assess preventive breast-health-seeking behaviors and measure family obligation stress (FO; range 6–18). Univariate and multivariate linear regression was used to assess associations between sociodemographic factors and FO. Univariate and multivariate linear regression (used in conjunction with the robust sandwich estimator for standard errors) and probability differences (PDs) were used to evaluate associations between preventive breast-health-seeking behaviors, sociodemographic factors, and FO.

Results
A total of 401 Ugandan women ages 25–74 participated in the survey. Most had three or more children in the home (60%) and were employed full time (69%). Higher FO was associated with increasing number of children and/or adults in the household (p &lt; .05), full-time employment (p &lt; .001), and being single (p = .003). Women with higher FO were less likely to participate in breast cancer education (PD = −0.02 per 1-point increase, p = .008) and preventive health check-ups (PD = −0.02, p = .018), associations that persisted on multivariate analysis controlling for sociodemographic factors.

Conclusion
Ugandan women with high FO are less likely to participate in preventive breast cancer detection efforts including breast cancer education and preventive health check-ups. Special efforts should be made to reach women with elevated FO, because it may be a risk factor for late-stage presentation among women who develop breast cancer.
Intracranial Response to Anti-Programmed Death 1 Therapy in a Patient with Metastatic Non-Small Cell Lung Cancer with Leptomeningeal Carcinomatosis
Authors: Kamath Suneel D. , Kumthekar Priya U. , Kruser Tim J. , Mohindra Nisha A. 
Published: August 2018

Abstract
Central nervous system metastasis in non-small cell lung cancer remains a therapeutic challenge and confers a poor prognosis. Here we describe a patient with lung adenocarcinoma, parenchymal brain metastases, and leptomeningeal carcinomatosis who demonstrated a sustained response to programmed death 1 inhibition combined with stereotactic radiosurgery.
PENGARUH TEMPERATUR DAN WAKTU HOMOGENISASI TERHADAP KARAKTERISTIK PELAT PADUAN AG3NE
Authors: Hadijaya Hadijaya , Aida Siti , Masrukan Masrukan 
Published: August 2018

PENGARUH TEMPERATUR DAN WAKTU HOMOGENISASI TERHADAP KARAKTERISTIK PELAT PADUAN AG3NE. Telah dilakukan penelitian mengenai pengaruh temperatur dan waktu homogenisasi terhadap karakteristik pelat paduan AG3NE. Paduan AG3NE merupakan paduan yang dapat digunakan sebagai kelongsong elemen bakar reaktor riset. Ingot hasil peleburan AlFeMgFeSi dicuplik untuk dilakukan beberapa pengujian diantaranya komposisi kimia, kekerasan, mikrostruktur, fasa, densitas dan korosi. Hasil pengujian komposisi kimia dipoeroleh unsur Al= 96,110%; Fe = 0,188%; Mg = 2,333 dan Si = 0,355%. Kekerasan AG3NE yang dikenai proses pendinginan cepat diperoleh sebesar 153,33 HV; sedangkan yang mengalami pendinginan lambat 72,70 HV, dan kekerasan paduan AlMgSi sebesar 79,30 HV. Hasil analisis mikrostruktur menggunakan mikroskop optik menunjukkan bahwa paduan AG3NE tanpa dihomogenisasi mempunyai bentuk butir pipih sebagian berbentuk dendrite dengan diameter butir rata-rata 0,02 mm sedangkan paduan AG3NE yang dihomogenisasi pada temperatur 500 oC dengan variasi waktu selama 1 ; 2; 3 dan 4 jam mempunyai butir dengan diameter rata-rata berturut-turut sebesar 0,01 mm, 0,02 mm, 0,03 mm dan 0,04 mm. Hasil uji fasa menggunakan XRD diperoleh fasa Al (ά) dan fasa kedua FeSiAl5 yang terdapat pada sudut 2θ sebesar 38,24o dan 44,446o dengan hkl masing-masing (119) dan (209) serta mempunyai intensitas sinar sebesar 100% dan 76,6%. Sementara itu dari hasil pengukuran densitas AG3NE diperoleh densitas rerata yang hampir sama dengan paduan AlMgSi sebagai pembanding. Densitas paduan AG3NE diperolehsebesar 2,6893 ± 0,0013 g/cm3 sedangkan AlMgSi 2,6910 ± 0,0283 g/cm3. Sementara itu, hasil uji korosi menunjukkan bahwa laju korosi paduan AG3NE lebih rendah dibandingkan dengan paduan AlMgSi. Hasil karakterisasi komposisi kimia, kekerasan mikro, mikrostruktur, densitas dan laju korosi dapat disimpulkan bahwa paduan AG3NE dapat digunakan sebagai kandidat kelongsong bahan bakar nuklir untuk reaktor riset.Kata kunci: Paduan AG3NE, AlMgSi, homogenisasi, karakterisasi, bahan struktur.
ANALISIS KESALAHAN MAHASISWA DALAM MENGGUNAKAN VERBA FURU, KUDARU, ORIRU DAN SAGARU SEBAGAI SINONIM
Authors: Novitasari Ayuningtyas , Judiasri Melia Dewi , Sutedi Dedi 
Published: August 2018

ABSTRAKPenelitian ini merupakan penelitian mengenai analisis kesalahan penggunaan verba furu, kudaru, oriru dan sagaru sebagai sinonim pada mahasiswa tingkat III tahun akademik 2015/2016 Departemen Pendidikan Bahasa Jepang FPBS UPI. Penelitian ini bertujuan untuk mengetahui kesalahan apa saja yang terjadi pada pembelajar bahasa Jepang dalam menggunakan verba furu, kudaru, oriru dan sagaru sebagai sinonim, mencari penyebab terjadinya kesalahan tersebut, dan upaya untuk mengurangi terjadinya kesalahan. Penelitian ini menggunakan metode deskriptif. Objek penelitian ini adalah mahasiswa tingkat III tahun akademik 2015/2016 Departemen Pendidikan Bahasa Jepang FPBS UPI dengan jumlah sampel sebanyak 60 orang. Pengambilan data dilakukan dengan teknik one shoot model. Pengumpulan data dilakukan melalui cara tes dan angket. Berdasarkan hasil analisis, kesalahan terhadap penggunaan verba furu adalah 26,67%, kesalahan terhadap penggunaan verba kudaru adalah 68,55%, kesalahan terhadap penggunaan verba oriru adalah 58,52%, dan kesalahan terhadap penggunaan verba sagaru adalah 59,99%. Faktor – faktor penyebab terjadinya kesalahan penggunaan verba furu, kudaru, oriru dan sagaru adalah kurangnya pemahaman mengenai penggunaan verba furu, kudaru, oriru dan sagaru dengan tepat, kurangnya pengetahuan mengenai fungsi verba furu, kudaru, oriru dan sagaru, dan kurangnya pemahaman mengenai persamaan dan perbedaan verba furu, kudaru, oriru dan sagaru. Kata Kunci : Sinonim, Furu, Kudaru, Oriru, Sagaru, kesalahan, analisis kesalahan ABSTRACTThis study is about the analysis of error regarding the use of Japanese synonym furu, kudaru, oriru, and sagaru by third years students of DPBJ FPBS UPI 2015/2016. The purpose of this study was to determine any errors that occur when using synonym furu, kudaru, oriru, and sagaru in on Japanese Language learner. The method used in this research is descriptive type of survey with the instrument in the form of objective test and questionnaire. Data collection was done by using one shoot models. The sample of this study is the third years students of DPBJ FPBS UPI 2015/2016, with a sample of 60 people. The result of this research shows, the error of use of furu verb are 26,67%, the error of use of kudaru verb are 68,55%, the error of use of oriru verb are 58,52%, and the error of use of sagaru verb are 59,99%. The cause of error on the use of Japanese synonym furu, kudaru, oriru, and sagaru are the lack of understanding of the use, lack of understanding of the differences, a lack of meaning and function of Japanese synonym furu, kudaru, oriru, and sagaru. Key word : Synonym Furu,Kudaru,Oriru, Sagaru, error, error analysis