bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vital (Johannine) Signs: ‘Crip-tic’ Enactments of a Man at the Pool (John 5:1-18)
Authors: Lawrence* Louise J. 
Published: May 2019

Abstract
John 5:1-18 is here interpreted ‘crip-tically’ (through a crip hermeneutic) which seeks to pay due attention to the man at the pool and his ‘enactments’. In order to subvert notions of what Alison Kafer has termed ‘curative time’, here this sign is seen to afford something other than a normalisation or physical healing of a body. Inspiration is drawn from two recent disability arts exhibits – Liz Crow’s Bedding Out (2012-2013) and Noëmi Lakmaier’s One Morning in May (2012) – and their respective illustrations of crip time and movement to highlight how the man in John 5:1-18 too has the potential to subversively refigure ‘normative’ understandings of time, space and embodiment within the Gospel.
Is Freedom an Existential Category in Ancient Discourse?
Authors: Livesey Nina E. 
Published: May 2019

Abstract
In much of the Christian exegetical tradition, freedom, ἐλευθερία, is considered an existential state. Hans Dieter Betz, for instance, assessed freedom as the “central theological concept which sums up the Christian’s situation before God as well as in this world” (1979: 255). Yet in his 2001 monograph, Constructing Autocracy, the classicist Matthew Roller explains that ancient authors only employed the terms libertas (“freedom”) and its complementary term servitus (“slavery”) together as metaphors to characterize another situation. Unless they were defining what it meant to be a free person or a slave (e.g., Dio Chrysostom, Or. 14, 15), ancient authors did not employ the terms “freedom” or “slavery” to designate a political or religious state of being. When employed paradigmatically, as commentary on another situation, the terms “freedom” and “slavery” carried important social and ethical implications. This article applies Roller’s insights to Paul’s use of freedom in Galatians.
Where Public Theology and Public Administration Meet
Authors: van Putten Robert , Overeem Patrick , van Steden Ronald 
Published: May 2019

Abstract
Since 9/11 Jürgen Habermas has paid considerable attention to religion in the public sphere. He has described contemporary Western societies as ‘post-secular’, arguing that believers and non-believers should show a mutually cooperative attitude and engage in complementary learning processes. Although public theologians have urged for policies that would encourage such collaboration, public administration scholars and practitioners seem to have completely neglected this call. In this article we inquire into the possibility of a ‘post-secular public administration’, which grants a more significant place to beneficial forms of religion in modern societies. By presenting a case study on Street Pastors in the British night-time economy we offer an example of both a post-secular religious contribution to the public sphere, as envisaged by Habermas, and a piece of post-secular empirical social science research. Finally, we critically assess Habermas’ post-secular turn within the context of a cross-narrative between public theology and public administration.
CJEU Judgment in Case C-284/16 Achmea: Single Decision and Its Multi-Faceted Fallout
Authors: Soloch Bartosz 
Published: May 2019

Abstract
Recent decisions of European and national courts, as well as those of arbitral tribunals, concerning the Achmea saga seem to be plentiful enough to draw preliminary conclusions as to the relationship between EU law, intra-EU international investment agreements (IIAs) and the national laws of EU-Member States. In order to get the proper picture of the situation, however, it is necessary not only to analyse the recent decisions of the Court of Justice of the European Union (CJEU) and their consequences from these three perspectives, but, equally, to understand how they interact with each other. Such an analysis indicates the real possibility of the emergence of a rift between the practice of the EU and national courts rejecting the validity of investment arbitration agreements, on the one hand, and investment tribunals, on the other. In any case, such a divergence would put into question the IIAs’ claim to provide a stable regulatory framework for international investments in the EU, which, in turn, would strengthen the argument for termination of intra-EU IIAs.
Procedural Developments at the International Court of Justice
Authors: Bordin Fernando Lusa 
Published: May 2019

Abstract
The present column covers procedural developments at the International Court of Justice for the period spanning from 1 April 2017 to 31 January 2019. Those comprise the interpretation of compromissory clauses; res judicata; admissibility challenges based on abuse of rights and abuse of process; conditions for the indication of provisional measures, in particular the requirement that the rights asserted be plausible; and the admissibility of counter-claims.
Doppler Radar Measurements of Spatial Turbulence Intensity in the Atmospheric Boundary Layer
Authors: Duncan James B. , Hirth Brian D. , Schroeder John L. 
Published: May 2019

AbstractRemote sensing instruments that scan have the ability to provide high-resolution spatial measurements of atmospheric boundary layer winds across a region. However, the time required to collect the volume of measurements used to produce this spatial representation of atmospheric winds typically limits the extraction of atmospheric turbulence information using traditional temporal analysis techniques. To overcome this constraint, a spatial turbulence intensity (STI) metric was developed to quantify atmospheric turbulence intensity (TI) through analysis of spatial wind field variability. The methods used to determine STI can be applied throughout the measurement domain to transform the spatially distributed velocity fields to analogous measurement maps of STI. This method enables a comprehensive spatial characterization of atmospheric TI. STI efficacy was examined across a range of wind speeds and atmospheric stability regimes using both single- and dual-Doppler measurements. STI demonstrated the ability to capture rapid fluctuations in TI and was able to discern large-scale TI trends consistent with the early evening transition. The ability to spatially depict atmospheric TI could benefit a variety of research disciplines such as the wind energy industry, where an understanding of wind plant complex flow spatiotemporal variability is limited.
Recent Warming Has Resulted in Smaller Gains in Net Carbon Uptake in Northern High Latitudes
Authors: Zhu Peng , Zhuang Qianlai , Welp Lisa , Ciais Philippe , Heimann Martin , Peng Bin , Li Wenyu , Bernacchi Carl , Roedenbeck Christian , Keenan Trevor F. 
Published: May 2019

AbstractCarbon balance of terrestrial ecosystems in the northern high latitudes (NHL) is sensitive to climate change. It remains uncertain whether current regional carbon uptake capacity can be sustained under future warming. Here the atmospheric CO2 drawdown rate (CDR) between 1974 and 2014, defined as the CO2 decrease in ppm over the number of days in spring or summer, is estimated using atmospheric CO2 observations at Barrow (now known as Utqiaġvik), Alaska. We found that the sensitivity of CDR to interannual seasonal air temperature anomalies has trended toward less carbon uptake for a given amount of warming over this period. Changes in interannual temperature sensitivity of CDR suggest that relatively warm springs now result in less of a carbon uptake enhancement. Similarly, relatively warm summers now result in greater carbon release. These results generally agree with the sensitivity of net carbon exchange (NCE) estimated by atmospheric CO2 inversion. When NCE was aggregated over North America (NA) and Eurasia (EA), separately, the temperature sensitivity of NCE in NA has changed more than in EA. To explore potential mechanisms of this signal, we also examine trends in interannual variability of other climate variables (soil temperature and precipitation), satellite-derived gross primary production (GPP), and Trends in Net Land–Atmosphere Carbon Exchanges (TRENDY) model ensemble results. Our analysis suggests that the weakened spring sensitivity of CDR may be related to the slowdown in seasonal soil thawing rate, while the summer sensitivity change may be caused by the temporally coincident decrease in temperature sensitivity of photosynthesis. This study suggests that the current NHL carbon sink may become unsustainable as temperatures warm further. We also found that current carbon cycle models do not represent the decrease in temperature sensitivity of net carbon flux. We argue that current carbon–climate models misrepresent important aspect of the carbon–climate feedback and bias the estimation of warming influence on NHL carbon balance.
A New Dynamical Core of the Global Environmental Multiscale (GEM) Model with a Height-Based Terrain-Following Vertical Coordinate
Authors: Husain Syed Zahid , Girard Claude , Qaddouri Abdessamad , Plante André 
Published: May 2019

AbstractA new dynamical core of Environment and Climate Change Canada’s Global Environmental Multiscale (GEM) atmospheric model is presented. Unlike the existing log-hydrostatic-pressure-type terrain-following vertical coordinate, the proposed core adopts a height-based approach. The move to a height-based vertical coordinate is motivated by its potential for improving model stability over steep terrain, which is expected to become more prevalent with the increasing demand for very high-resolution forecasting systems. A dynamical core with height-based vertical coordinate generally requires an iterative solution approach. In addition to a three-dimensional iterative solver, a simplified approach has been devised allowing the use of a direct solver for the new dynamical core that separates a three-dimensional elliptic boundary value problem into a set of two-dimensional independent Helmholtz problems. The issue of dynamics–physics coupling has also been studied, and incorporating the physics tendencies within the discretized dynamical equations is found to be the most acceptable approach for the height-based vertical coordinate. The new dynamical core is evaluated using numerical experiments that include two-dimensional nonhydrostatic theoretical cases as well as 25-km resolution global forecasts. For a wide range of horizontal grid resolutions—from a few meters to up to 25 km—the results from the direct solution approach are found to be equivalent to the iterative approach for the new dynamical core. Furthermore, results from the different numerical experiments confirm that the new height-based dynamical core is equivalent to the existing pressure-based core in terms of solution accuracy.
A Virtual-Reality Training Simulator for Cochlear Implant Surgery
Authors: Jones Blake , Rohani Seyed Alireza , Ong Nelson , Tayeh Tarek , Chalabi Ahmad , Agrawal Sumit K. , Ladak Hanif M. 
Published: May 2019

Background and Objectives. Hearing loss is one of the most prevalent chronic conditions and can significantly impact an individual’s quality of life. Cochlear implantation (CI) is a widely applicable treatment for severe to profound hearing loss, however CI surgery can be difficult for surgical trainees to master. Training environments that are safe, controlled, and affordable are needed. To this end, we present a virtual-reality (VR) cochlear implant surgical simulator developed with a popular, commercial game engine. Method. Unity3D was used to develop the simulator and model the delicate instruments involved. High-resolution models of human cochleae were created from images obtained from synchrotron-radiation phase-contrast imaging (SR-PCI). The physical-realism of the simulator was assessed via a comparison with fluoroscopic images of an actual cochlear implant insertion. Different resolutions of cochlear models were used to benchmark the real-time capabilities of the simulator with the number of frames per second (FPS) serving as the performance metric. Results. Quantitative analysis comparing the simulated procedure to fluoroscopic imaging revealed no significant differences. Qualitatively, the behaviour of the inserted and simulated implants were similar throughout the entirety of the procedure. The simulator was able to maintain 25 FPS even when experiencing an artificially high computational load. Conclusion. VR simulators provide a new and exciting avenue to enhance current medical education. Continued use of widely available and supported game engines in the development of medical simulators will hopefully result in lowered costs. Preliminary feedback from expert surgeons of the simulator presented here has been positive and future work will focus on evaluating face, content and construct validity.
Gene regulation through dynamic actin control of nuclear structure
Authors: Sankaran Jeyantt , Uzer Gunes , van Wijnen Andre J , Rubin Janet 
Published: May 2019

Bone marrow mesenchymal stem cells exist in a multipotential state, where osteogenic and adipogenic genomes are silenced in heterochromatin at the inner nuclear leaflet. Physical force, generated in the marrow space during dynamic exercise exerts control overexpression of differentiation. Mesenchymal stem cells experience mechanical force through their cytoskeletal attachments to substrate, inducing signaling that alters gene expression. The generated force is further transferred from the cytoskeleton to the nucleoskeleton through tethering of actin to Linker of Nucleus and Cytoskeleton (LINC) complexes. Forces exerted on LINC alter the shape and placement of the nucleus within the cell, and are ultimately transferred into the nucleus. LINC complexes transverse the nuclear membrane and connect to the internal nucleoskeleton that is made up of lamin filaments and actin. Force transfer through LINC thus causes structural rearrangements of the nuclear scaffolding upon which chromosomes are arranged. Gene availability is not only modulated through heterochromatin remodeling enzymes and active transcription factors but also by control of nucleoskeletal structure and nuclear enzymes that mediate actin polymerization in the nucleus. Nuclear actin structure may be affected by similar force-activated pathways as those controlling the cytoplasmic actin cytoskeleton and represent a critical determinant of mesenchymal stem cell lineage commitment.Impact statementGene expression is controlled by nuclear structure which is modulated by both internal and external forces exerted on the nucleoskeleton. Extracellular forces experienced through the actin cytoskeleton are transmitted to the internal nucleoskeleton via Linker of Nucleus and Cytoskeleton (LINC) protein connections. LINC complexes directly alter nuclear shape and entry of molecules that regulate transcription. New mechanistic models indicate that nuclear actin is a dynamic component of the filamentous nucleoskeleton and modified by an intranuclear “actin toolbox”, a set of enzymes that regulate linear and branched polymerization of nuclear actin. External stimulation of both biomechanical and biochemical pathways alters nuclear actin structure and has profound effects on gene expression by controlling chromatin architecture and transcription factor access to gene targets. The available data indicate that nucleoskeletal control of gene expression is critical for self-renewal and mesenchymal lineage-allocation in stem cells.
An Evaluation of Monitoring Surveys of the Quarantine Bacterium Xylella Fastidiosa Performed in Containment and Buffer Areas of Apulia, Southern Italy
Authors: Scortichini Marco , Cesari Gianluigi 
Published: May 2019

Introduction: Xylella fastidiosa is a quarantine phytopathogen for the European Plant Protection Organization and currently infects olive trees in the Apulia region (southern Italy). Upon the Implementing Decision of the European Union 2016/764 of May 12, 2016, extensive monitoring surveys were performed on approximately 190 000 ha to ascertain the possible occurrence of X. fastidiosa. Objectives: The primary objectives of the analysis were to start to collect epidemiological data on X. fastidiosa occurrence in areas far from the initial outbreaks and discuss the results of the pathogen detection. Methods: A total of 220 279 olive trees were inspected. Basic information on farm and trees management was obtained. A total of 13 706 olive trees were analyzed through serological and molecular techniques to verify the possible occurrence of the bacterium. Results: The cultivars “Nociara,” “Cima di Melfi,” and “Cellina di Nardò” showed the highest occurrence of decline symptoms. Tree age appears to be related to the incidence of decline symptoms. Olive trees growing in well-managed soils showed fewer symptoms than trees cultivated in farms where such agronomic techniques are not regularly performed. X. fastidiosa was detected in 2078 samples taken from symptomatic trees and 1653 samples obtained from asymptomatic trees. In 3300 samples taken from symptomatic trees, the bacterium was not detected. Conclusions: Implementation and utilization of reliable in situ detection techniques could increase the number of sampled trees in each plot, thus allowing a more extensive and robust assessment of X. fastidiosa–infected plants in areas where the pathogen inoculums are still low.
Dementia Friendly Hospital Design: Key Issues for Patients and Accompanying Persons in an Irish Acute Care Public Hospital
Authors: Xidous Dimitra , Grey Tom , Kennelly S. P. , McHale Cathy , O’Neill Desmond 
Published: May 2019

Objectives: Research was conducted to investigate the impact of the hospital environment on older people including patients with dementia and their accompanying persons (APs). The article presents key research findings in the case study hospital. Background: For many patients, the hospital is challenging due to the busy, unfamiliar, and stressful nature of the environment. For a person with dementia, the hospital experience can be exacerbated by cognitive impairment and behavioral or psychological symptoms and can therefore prove to be a frightening, distressing, and disorientating place. Method: The findings are based on a stakeholder engagement process where the research team spent approximately 150 hr observing within the hospital, administered 95 questionnaires to patients and/or APs, and conducted 12 structured interviews with patients and APs. A thematic analysis was employed to analyze and generate key themes emerging from the process. Results: Themes were grouped into overarching issues and design issues across spatial scales. Conclusion: This research confirms the negative impact of the acute hospital setting on older people with cognitive impairments including dementia and delirium. The multiple perspectives captured in this study, including most importantly people with dementia, ensure that stakeholder needs can be used to inform the design of the hospital environment. The research points to the value of understanding the lived experience of the person with dementia and APs. The voices of patients, particularly persons with dementia and their APs, are a crucial element in helping hospitals to fulfill their role as caregiving and healing facilities.
RETRACTED ARTICLE: Long non-coding RNA AGAP2-AS1, functioning as a competitive endogenous RNA, upregulates ANXA11 expression by sponging miR-16-5p and promotes proliferation and metastasis in hepatocellular carcinoma
Authors: Liu Zhikui , Wang Yufeng , Wang Liang , Yao Bowen , Sun Liankang , Liu Runkun , Chen Tianxiang , Niu Yongshen , Tu Kangsheng , Liu Qingguang 
Published: May 2019

Abstract
Background
Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) in the biological behaviors of hepatocellular carcinoma (HCC). Here, we elucidated the function and possible molecular mechanisms of the effect of lncRNA-AGAP2-AS1 on the biological behaviors of HCC.

Methods
EdU, Transwell and flow cytometry were used to determine proliferation, migration, invasion and apoptosis of HCC cells in vitro. The subcutaneous tumor model and lung metastasis mouse model in nude mice was established to detect tumor growth and metastasis of HCC in vivo. The direct binding of miR-16-5p to 3’UTR of ANXA11 was confirmed by luciferase reporter assay. The expression of AGAP2-AS1 and miR-16-5p in HCC specimens and cell lines were detected by real-time PCR. The correlation among AGAP2-AS1 and miR-16-5p were disclosed by a dual-luciferase reporter assay, RIP assay and biotin pull-down assay.

Results
Here, we demonstrated that AGAP2-AS1 expression was up-regulated in HCC tissues and cell lines, especially in metastatic and recurrent cases. Gain- and loss-of-function experiments indicated that AGAP2-AS1 promoted cell proliferation, migration, invasion, EMT progression and inhibited apoptosis of HCC cells in vitro and in vivo. Further studies demonstrated that AGAP2-AS1 could function as a competing endogenous RNA (ceRNA) by sponging miR-16-5p in HCC cells. Functionally, gain- and loss-of-function studies showed that miR-16-5p promoted HCC progression and alteration of miR-16-5p abolished the promotive effects of AGAP2-AS1 on HCC cells. Moreover, ANXA11 was identified as direct downstream targets of miR-16-5p in HCC cells, and mediated the functional effects of miR-16-5p and AGAP2-AS1 in HCC, resulting in AKT signaling activation. Clinically, AGAP2-AS1 and miR-16-5p expression were markedly correlated with adverse clinical features and poor prognosis of HCC patients. We showed that hypoxia was responsible for the overexpression of AGAP2-AS1 in HCC. And the promoting effects of hypoxia on metastasis and EMT of HCC cells were reversed by AGAP2-AS1 knockdown.

Conclusions
Taken together, this research supports the first evidence that AGAP2-AS1 plays an oncogenic role in HCC via AGAP2-AS1/miR-16-5p/ANXA11/AKT axis pathway and represents a promising therapeutic strategy for HCC patients.
Implementation of motivational interviewing in a fall prevention exercise program: experiences from a randomized controlled trial
Authors: Arkkukangas Marina , Hultgren Staffan 
Published: May 2019

Abstract
Objective
The elderly population over 65 is increasing globally, and interventions promoting health and preventive work, especially fall prevention, will constitute a large part of physiotherapists’ duties in the near future. To address the challenges of promoting effective and sustainable health behavior changes among older persons, physiotherapists need support when it comes to how to apply behavior change strategies, especially in fall prevention. Therefore, the aim of this study was to describe implementation of motivational interviewing in a fall prevention exercise program. This study is a side product of another project.

Results
Data from a recently performed three-armed randomized controlled trial were used to describe the implementation of motivational interviewing in the exercise group (n = 58). Level of motivation (priorities) and self-efficacy for both the physiotherapist and the participant in treatment, and to use a guide targeted towards the planned treatment are recommended actions. Regular meetings and follow ups as well as updates of motivational interviewing skills during a treatment period, should also be considered to achieve treatment fidelity.
Trial registration NCT01778972, Retrospectively registered January 29, 2013