bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of PSSS‐grafted polysulfone microfiltration membrane and its rejection and removal properties towards heavy metal ions
Authors: Gao Baojiao , Zhang Dandan , Li Yanbin 
Published: January 2019

3‐Hydroxy‐N,N‐diethylaniline (HDEA) as a tertiary aromatic amine was introduced onto the surface of chloromethylated polysulfone (CMPSF) microfiltration membrane through modification reaction, resulting in the modified membrane PSF‐DEA. A redox surface‐initiating system (DEA/APS) was constituted by the bonded tertiary aromatic amine group DEA and ammonium persulfate (APS) in aqueous solution, and so, the free radicals formed on the membrane initiated sodium p‐styrenesulfonate (SSS) as an anionic monomer to produce graft polymerization, getting the grafting‐type composite microfiltration membrane, PSF‐g‐PSSS membrane. Subsequently, the adsorption property of PSF‐g‐PSSS membrane for three heavy metal ions, Pb2+, Zn2+, and Hg2+ ions, was fully examined, and the rejection performance of PSF‐g‐PSSS membrane towards the three heavy metal ions was emphatically evaluated via permeation experiments. The experimental results show that by the initiating of the surface‐initiating system of DEA/APS, the graft polymerization can smoothly be carried out under mild conditions. PSF‐g‐PSSS membrane as a functional microfiltration membrane has strong adsorption ability for heavy metal ions by right of strong electrostatic interaction (or ion exchange action) between the anionic sulfonate ions on the membrane and heavy metal ions. The order of adsorption capacity is Pb2+ > Zn2+ > Hg2+, and the adsorption capacity of Pb2+ ion gets up to 2.18 μmol/cm2. As the volume of permeation solutions, in which the concentrations of the three metal ions are 0.2 mmol/L, are in a range of 50 to 70 mL, the rejection rate of PSF‐g‐PSSS membrane for the three heavy metal ions can reach a level of 95%, displaying a fine rejection and removing performance towards heavy metal ions.
Proteomic Approach to the Potential Role of Angiotensin II in Barrett Dysplasia
Authors: Bratlie Svein Olav , Wallenius Ville , Edebo Anders , Fändriks Lars , Casselbrant Anna 
Published: January 2019

Background and AimDysplasia in Barrett's esophagus (BE) is regarded as a preneoplastic lesion. The renin–angiotensin system (RAS), known for its role in electrolyte homeostasis and hemodynamics, has also been shown to have tissue‐based features linked to proliferation, inflammation, and cancer. RAS is associated with BE dysplasia. The aim of this study is to investigate possible effects of the RAS in BE dysplasia by using RAS‐interfering pharmaceutical agents and by assessment of global protein expression in esophageal mucosal biopsies.MethodsEndoscopic biopsies are taken from 18 BE in patients with low‐grade dysplasia before and after 3 weeks of treatment with either angiotensin‐converting enzyme inhibitors (enalapril 5 mg; n = 6) or angiotensin II receptor type 1 blockers (candesartan 8 mg; n = 6), or no treatment (n = 6). A global proteomics analysis by 2D gel electrophoresis and mass spectrometry (MS) is then performed to identify proteins that are regulated after interference with RAS.ResultsThree proteins are identified to show significant modulation of expression 60 kDa heat shock protein (downregulated), protein disulfide isomerase A3 (downregulated), and inorganic pyrophosphatase (upregulated).ConclusionThree proteins with no previously known links to esophageal RAS, but with possible relevance for the development of esophageal adenocarcinoma (EAC) are detected. Altered expression by interference with the RAS suggests an involvement of angiotensin II in the development of EAC in BE.
Stearate‐Induced Apoptosis in Human Pancreatic β‐Cells is Associated with Changes in Membrane Protein Expression and These Changes are Inhibited by Oleate
Authors: Němcová‐Fürstová Vlasta , Balušíková Kamila , Halada Petr , Pavlíková Nela , Šrámek Jan , Kovář Jan 
Published: January 2019

PurposeLipotoxicity is implicated in type 2 diabetes pathogenesis. Its molecular mechanisms are not completely understood. The aim of this study is to identify new suspect proteins involved in pancreatic β‐cell death induction by saturated fatty acids and its inhibition by unsaturated fatty acids.Experimental designEmploying 2DE analysis and subsequent western blot confirmation, the differences in membrane/membrane‐associated protein expression in human β‐cell line NES2Y are assessed during cell death induction by stearate and its inhibition by oleate.ResultsInduction of apoptosis by stearate is associated with significantly increased levels of Hsp90β, peroxiredoxin‐1, and 14‐3‐3γ in the membrane fraction of NES2Y cells and significantly decreased levels of annexin A2, annexin A4, and reticulocalbin‐2. All these changes are significantly inhibited by oleate co‐application. No expression changes are detected after application of stearate together with oleate. Furthermore, the expression of reticulocalbin‐2 is significantly decreased after stearate application also in the whole cell lysate.Conclusions and clinical relevanceSeveral membrane‐associated proteins that could be related to pro‐ and anti‐apoptotic signaling initiated by fatty acids in human pancreatic β‐cells are identified. As far as we know, annexin A4, reticulocalbin‐2, and 14‐3‐3γ represent novel molecules related to the effect of fatty acids on β‐cell viability.
Superconducting Nanowires for Single‐Photon Detection: Progress, Challenges, and Opportunities
Authors: Holzman Itamar , Ivry Yachin 
Published: January 2019

AbstractSingle‐photon detectors and nanoscale superconducting devices are two major candidates for realizing quantum technologies. Superconducting‐nanowire single‐photon detectors (SNSPDs) comprise these two solid‐state and optic aspects enabling high‐rate (1.3 Gb s−1) quantum key distribution over long distances (>400 km), long‐range quantum communication (>1200 km), as well as space communication (239 000 miles). The attractiveness of SNSPDs stems from competitive performance in the four single‐photon relevant characteristics at wavelengths ranges from UV to the mid‐IR: high detection efficiency, low false‐signal rate, low uncertainty in photon time arrival, and fast reset time. However, to date, these characteristics cannot be optimized simultaneously. In this review, the mechanisms that govern these four characteristics are presented, and it is demonstrated how they are affected by material properties and device design as well as by the operating conditions, allowing aware optimization of SNSPDs. Based on the evolution in the existing literature and state of the art, it is proposed how to choose or design the material and device for optimizing SNSPD performance, while possible future opportunities in the SNSPD technology are also highlighted.
Land cover impacts on storm flow suspended solid and nutrient concentrations in southwest Ohio streams
Authors: Lazar Jeffrey A. , Spahr Rachel , Grudzinski Bartosz P. , Fisher Thomas J. 
Published: January 2019

AbstractImpacts between urban and agricultural land cover on storm flow water quality are poorly understood for the Eastern Corn Belt Ecoregion in SW Ohio. Storm flow water samples were collected from May 2017 to October 2017 across seven SW Ohio watersheds which ranged in urban land cover from 6% to 92% and in agricultural land cover from 4% to 70%. Two watersheds contained water resource recovery facilities (WRRFs). Percent agricultural land cover in a watershed and storm magnitude were primary explanatory variables for total suspended solid and total phosphorus concentrations. Total nitrogen, nitrate, and phosphate concentrations were primarily explained by the presence of WRRFs and percent agricultural land cover. Increased dissolved nutrient concentrations in watersheds with WRRFs indicate that WRRFs in the study area are ineffectively removing nitrate and phosphate from effluent. Results suggest that to improve water quality during storm flows, additional management efforts need to be focused on agricultural watersheds and WRRFs.Practitioner points

Storm flow water quality in the study area is significantly affected by land cover, WRRF Q, and storm Q.

TSS and TP concentrations are best explained by percent of agricultural land cover in a watershed and magnitude of storms.

TN, NO3‐N, and concentrations are best explained by WRRF Q, followed by the percent agricultural land cover.

This study shows that agricultural land cover and WRRFs play a significant role in water quality degradation in SW Ohio.
Perceived parentalguanand school adjustment among Chinese early adolescents: The moderating role of interdependent self‐construal
Authors: Lan Xiaoyu , Scrimin Sara , Moscardino Ughetta 
Published: January 2019

ABSTRACTIntroductionPrevious research suggests that supportive parenting is positively related to adolescents' academic and psychological functioning. However, most extant research has focused on parenting styles observed in Western countries, whereas less is known about the role of culturally specific parenting dimensions in Eastern countries such as China. The purpose of this study was to examine the association between parentalguanand school adjustment in Mainland Chinese early adolescents, postulating moderation by interdependent self‐construal (ISC).MethodsParticipants were 148 early adolescents (48.6% girls) aged between 10 and 13 years, who completed a questionnaire survey. Teachers rated their students' school‐related social competence, while academic grades were obtained from school records.ResultsLinear regression models controlling for age, gender, and socioeconomic status showed that maternalguanwas positively associated with social competence. Furthermore, ISC moderated the link between maternalguanand school adjustment. Specifically, high levels of ISC were found to enhance the positive relation between perceived maternalguanand both social competence and academic performance. However, no significant associations were found for paternalguan.ConclusionsOur findings extend prior research by documenting the positive role ofguanparenting style and ISC in early adolescents' school adjustment, and underscore the centrality of mothers in the childrearing process within Chinese families.
Pseudo-differential operators with nonlinear quantizing functions
Authors: Esposito Massimiliano , Ruzhansky Michael 
Published: January 2019

AbstractIn this paper we develop the calculus of pseudo-differential operators corresponding to the quantizations of the form$$Au(x)=\int_{{\open R}^n}\int_{{\open R}^n}e^{{\rm i}(x-y)\cdot\xi}\sigma(x+\tau(y-x),\xi)u(y)\,{\rm d}y\,{\rm d}\xi,$$where$\tau :{\open R}^n\to {\open R}^n$is a general function. In particular, for the linear choices$\tau (x)=0$,$\tau (x)=x$and$\tau (x)={x}/{2}$this covers the well-known Kohn–Nirenberg, anti-Kohn–Nirenberg and Weyl quantizations, respectively. Quantizations of such type appear naturally in the analysis on nilpotent Lie groups for polynomial functionsτand here we investigate the corresponding calculus in the model case of${\open R}^n$. We also give examples of nonlinearτappearing on the polarized and non-polarized Heisenberg groups.
Multiplicity and concentration results for a fractional Schrödinger-Poisson type equation with magnetic field
Authors: Ambrosio Vincenzo 
Published: January 2019

AbstractThis paper is devoted to the study of fractional Schrödinger-Poisson type equations with magnetic field of the type
$$\varepsilon^{2s}(-\Delta)_{A/\varepsilon}^{s}u + V(x)u + {\rm e}^{-2t}(\vert x \vert^{2t-3} \ast \vert u\vert ^{2})u = f(\vert u \vert^{2})u \quad \hbox{in} \ \open{R}^{3},$$
where ε > 0 is a parameter, s, t ∈ (0, 1) are such that 2s+2t>3, A:ℝ3 → ℝ3 is a smooth magnetic potential, (−Δ)As is the fractional magnetic Laplacian, V:ℝ3 → ℝ is a continuous electric potential and f:ℝ → ℝ is a C1 subcritical nonlinear term. Using variational methods, we obtain the existence, multiplicity and concentration of nontrivial solutions for e > 0 small enough.
Twists and shear maps in nonlinear elasticity: explicit solutions and vanishing Jacobians
Authors: Bevan Jonathan J. , Käbisch Sandra 
Published: January 2019

AbstractIn this paper we study constrained variational problems that are principally motivated by nonlinear elasticity theory. We examine, in particular, the relationship between the positivity of the Jacobian det ∇u and the uniqueness and regularity of energy minimizers u that are either twist maps or shear maps. We exhibit explicit twist maps, defined on two-dimensional annuli, that are stationary points of an appropriate energy functional and whose Jacobian vanishes on a set of positive measure in the annulus. Within the class of shear maps we precisely characterize the unique global energy minimizer $u_{\sigma }: \Omega \to {\open R}^2$ in a model, two-dimensional case. We exploit the Jacobian constraint $\det \nabla u_{\sigma} \gt 0$ a.e. to obtain regularity results that apply ‘up to the boundary’ of domains with corners. It is shown that the unique shear map minimizer has the properties that (i) $\det \nabla u_{\sigma }$ is strictly positive on one part of the domain Ω, (ii) $\det \nabla u_{\sigma } = 0$ necessarily holds on the rest of Ω, and (iii) properties (i) and (ii) combine to ensure that $\nabla u_{\sigma }$ is not continuous on the whole domain.
Associations between urinary iodine concentration, lipid profile and other cardiometabolic risk factors in adolescents: a cross-sectional, population-based analysis
Authors: Wang Xiaoxia , Xian Tongzhang , Zhang Lina , Jia Xiaofan , Man Fuli , Liu Li , Zhang Jie , Zhang Xianbo , Yu Dongni , Sun Liang , Zhou Qi , Pan Qi , Guo Lixin 
Published: January 2019

AbstractLow urinary iodine concentration (UIC) is associated with dyslipidaemia in adults but is not well characterised in adolescents. Because dyslipidaemia is a cardiovascular risk factor, identifying such an association in adolescents would allow for the prescription of appropriate measures to maintain cardiovascular health. The present study addresses this question using data in the 2001–2012 National Health and Nutrition Examination Survey for 1692 adolescents aged 12–19 years. Primary outcomes were UIC, cardiometabolic risk factors and dyslipidaemia. Data for subjects categorised by low and normal UIC and by sex were analysed by univariate and multivariate logistic regression. Treating UIC as the independent variable, physical activity level, apoB and lipid profiles differed significantly between subjects with low and normal UIC. Subjects with low UIC had a significantly greater risk of elevated total cholesterol (TC) (95 % CI 1·37, 2·81), elevated non-HDL (95 % CI 1·33, 2·76) and elevated LDL (95 % CI 1·83, 4·19) compared with those with normal UIC. Treating UIC as a dependent variable, the risk of low UIC was significantly greater in those with higher apoB (95 % CI 1·52, 19·08), elevated TC (≥4·4mmol/l) (95 % CI 1·37, 2·81) and elevated non-HDL (≥3·11mmol/l) (95 % CI 1·33, 2·76) than in those with normal UIC. These results show that male and female adolescents with low UIC tend to be at greater risk of dyslipidaemia and abnormal cardiometabolic biomarkers, though the specific abnormal parameters differed between sexes. These results may help to identify youth who would benefit from interventions to improve their cardiometabolic risk.
Geographical variation in life-history traits suggests an environmental-dependent trade-off between juvenile growth rate and adult lifespan in a moth
Authors: Chen C. , Yang H. , Xue F. , Xia Q. 
Published: January 2019

AbstractLife-history theory predicts a trade-off between the juvenile growth rate and adult traits related to survival. However, this hypothesized negative correlation is difficult to test robustly because many trade-offs are mild, and environmental variables, such as changes in nutrient availability, can ameliorate the trade-off or make it more pronounced. Thus, it is reasonable to expect that the expression of the trade-off can be condition-dependent. In the present study, we first examined the pre-adult life-history traits of the cotton bollworm, Helicoverpa armigera, collected from northern, central, and southern China at different temperatures. We found that the northern China population has a significantly shorter pre-adult developmental time and higher growth rate than the southern China population as a result of adaptation to the decreased seasonal length. Then, we tested for a trade-off between the juvenile growth rate and adult lifespan in different temperature and nutrient conditions. We found a negative relationship between juvenile growth rate and adult lifespan under starvation or desiccation conditions; however, a continuous supply of sugar can diminish or obviate the apparent negative relationship, in which the adult lifespan did not show a significant difference in most of the comparisons. These results suggested a resource-mediated trade-off may exist between juvenile growth rate and adult lifespan. However, the adult size may have some positive effect on the lifespan under starvation and desiccation conditions, which may affect the expression of trade-off.
RETRACTED ARTICLE: Sirt3 suppresses calcium oxalate-induced renal tubular
epithelial cell injury via modification of FoxO3a-mediated autophagy
Authors: Peng Yonghan , Yang Cheng , Shi Xiaolei , Li Ling , Dong Hao , Liu Changcheng , Fang Ziyu , Wang Zeyu , Ming Shaoxiong , Liu Min , Xie Bin , Gao Xiaofeng , Sun Yinghao 
Published: January 2019

AbstractHigh oxalic acid and calcium oxalate (CaOx)-induced renal tubular
epithelial cell (TEC) injury plays a key role in nephrolithiasis. However, the
mechanism remains unknown. Gene array analysis of the mice nephrolithiasis model
indicated significant downregulation of sirtuin 3 (Sirt3) and activation of
mitogen-activated protein kinase (MAPK) pathway. Kidney biopsy tissues of renal
calculi patients also showed decreased Sirt3 expression. Silencing Sirt3 exacerbated
oxidative stress and TEC death under CaOx stimulation. Restoring Sirt3 expression by
overexpression or enhancing its activity protected renal function and reduced TEC
death both in vitro and in vivo. Inhibiting the MAPK pathway resulted in
upregulation of Sirt3 expression, preservation of renal function and decreased cell
death both in vitro and in vivo. Furthermore, Sirt3 could upregulate FoxO3a activity
post-translationally via deacetylation, dephosphorylation and deubiquitination.
FoxO3a was found to interact with the promoter region of LC3B and to increase its
expression, enhancing TEC autophagy and suppressing cell apoptosis and necrosis.
Taken together, our results indicate that the MAPK/Sirt3/FoxO3a pathway modulates
renal TEC death and autophagy in TEC injury.
ISL1 predicts poor outcomes for patients with gastric cancer and drives tumor progression through binding to the ZEB1 promoter together with SETD7
Authors: Guo Ting , Wen Xian-Zi , Li Zi-yu , Han Hai-bo , Zhang Chen-guang , Bai Yan-hua , Xing Xiao-Fang , Cheng Xiao-jing , Du Hong , Hu Ying , Wang Xiao-Hong , Jia Yong-Ning , Nie Meng-Lin , Xie Meng , Li Qing-Da , Ji Jia-Fu 
Published: January 2019

AbstractISL1, a LIM-homeodomain transcription factor, serves as a biomarker of metastasis in multiple tumors. However, the function and underlying mechanisms of ISL1 in gastric cancer (GC) have not been fully elucidated. Here we found that ISL1 was frequently overexpressed in GC FFPE samples (104/196, 53.06%), and associated with worse clinical outcomes. Furthermore, the overexpression of ISL1 and loss-of-function of ISL1 influenced cell proliferation, invasion and migration in vitro and in vivo, including GC patient-derived xenograft models. We used ChIP-seq and RNA-seq to identify that ISL1 influenced the regulation of H3K4 methylation and bound to ZEB1, a key regulator of the epithelial–mesenchymal transition (EMT). Meanwhile, we validated ISL1 as activating ZEB1 promoter through influencing H3K4me3. We confirmed that a complex between ISL1 and SETD7 (a histone H3K4-specific methyltransferase) can directly bind to the ZEB1 promoter to activate its expression in GC cells by immunoprecipitation, mass spectrometry, and ChIP-re-ChIP. Moreover, ZEB1 expression was significantly positively correlated with ISL1 and was positively associated with a worse outcome in primary GC specimens. Our paper uncovers a molecular mechanism of ISL1 promoting metastasis of GC through binding to the ZEB1 promoter together with co-factor SETD7. ISL1 might be a potential prognostic biomarker of GC.
An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair
Authors: Chen Hao , Cheng Ruoyu , Zhao Xin , Zhang Yuhui , Tam Allison , Yan Yufei , Shen Haokai , Zhang Yu Shrike , Qi Jin , Feng Yonghai , Liu Lei , Pan Guoqing , Cui Wenguo , Deng Lianfu 
Published: January 2019

AbstractWe report here an injectable, self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic wound regeneration. The hydrogel was prepared by coordinative cross-linking of multi-arm thiolated polyethylene glycol (SH-PEG) with silver nitrate (AgNO3). Due to the dynamic nature of Ag-S coordination bond and bacteria-killing activity of Ag+, the resultant coordinative hydrogel featured self-healing, injectable and antibacterial properties. In this study, we synchronously loaded an angiogenic drug, desferrioxamine (DFO), in the coordinative hydrogel during cross-linking. We finally obtained a multifunctional hydrogel that is manageable, resistant to mechanical irritation, antibacterial and angiogenic in vitro. Our in vivo studies further demonstrated that the injectable self-healing hydrogel could efficiently repair diabetic skin wounds with low bacteria-infection and enhance angiogenic activity. In short, besides diabetic skin wound repair, such dynamic multifunctional hydrogel scaffolds would show great promise in the regeneration of different types of exposed wounds, in particular, in situations with disturbed physiological functions, high risk of bacterial infections, and external mechanical irritation.
Single-cell RNA-seq denoising using a deep count autoencoder
Authors: Eraslan Gökcen , Simon Lukas M. , Mircea Maria , Mueller Nikola S. , Theis Fabian J. 
Published: January 2019

AbstractSingle-cell RNA sequencing (scRNA-seq) has enabled researchers to study gene expression at a cellular resolution. However, noise due to amplification and dropout may obstruct analyses, so scalable denoising methods for increasingly large but sparse scRNA-seq data are needed. We propose a deep count autoencoder network (DCA) to denoise scRNA-seq datasets. DCA takes the count distribution, overdispersion and sparsity of the data into account using a negative binomial noise model with or without zero-inflation, and nonlinear gene-gene dependencies are captured. Our method scales linearly with the number of cells and can, therefore, be applied to datasets of millions of cells. We demonstrate that DCA denoising improves a diverse set of typical scRNA-seq data analyses using simulated and real datasets. DCA outperforms existing methods for data imputation in quality and speed, enhancing biological discovery.