bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hole Conduction of Tungsten Diselenide Crystalline Transistors by Niobium Dopant
Authors: Chu Dongil , Kim Eun Kyu 
Published: November 2018

AbstractIn spite of its ambipolar character, tungsten diselenide (WSe2) is known as one of a few p‐type materials among transition metal dichalcogenides and is currently being used as a fundamental building block of homo‐ and heterojunctions to meet the essential requirement of electronic devices. Many studies have solved the hole transport of WSe2 by contact engineering; however, another route is shown by an effective p‐doping strategy for achieving reliable p‐type transistor. Diverse characterization methods confirm the transition of the Fermi level from near midgap in intrinsic WSe2 to lower half bandgap with niobium substitutional doping, leading to a nondegenerate doping level exceeding a 1017–1018 cm−3 hole concentration. As a consequence, current on/off ratio and swing parameter have improved correspondingly as expected. The WSe2 transistors (with and without doping) are examined by the Zerbst‐type method to conduct the transient data analysis enabling the systemic characterization of the generation lifetime and surface generation velocity of WSe2. It is demonstrated that the lifetime for WSe2 is commonly in the 0.5–0.1 μs range. The generation velocity is ≈10 000‐fold slower than that of the typical crystalline silicon, which is attributed to the ultrathin body nature of the materials.
Noninvasive exosomal proteomic biosignatures, including cystatin SN, peroxiredoxin‐5, and glycoprotein VI, accurately predict chronic rhinosinusitis with nasal polyps
Authors: Mueller Sarina K. , Nocera Angela L. , Dillon Simon T. , Gu Xuesong , Wendler Olaf , Otu Hasan H. , Libermann Towia A. , Bleier Benjamin S. 
Published: November 2018

BackgroundExosomes are secreted epithelial‐derived vesicles that contain a conserved protein array representative of their parent cell. Exosomes may be reproducibly and noninvasively purified from nasal mucus. The exosomal proteome can be quantified using SOMAscanTM, a highly multiplexed, aptamer‐based proteomic platform. The purpose of this study was to determine whether chronic rhinosinusitis with nasal polyps (CRSwNP) has a unique predictive exosomal proteomic biosignature.MethodsExosomes were isolated from whole mucus sampled from control and CRSwNP patients (n = 20 per group) by differential ultracentrifugation. The SOMAscanTM platform was used to simultaneously quantify 1310 biologically relevant human proteins. Matched tissue and whole mucus proteomes were also analyzed. Differential protein expression and discriminatory power were calculated using the unweighted pair group method with arithmetic‐mean and principal component analysis, respectively. Bioinformatic analysis was performed using Ingenuity Pathway, MetaCore, and GeneMANIA analyses.ResultsThe exosomal proteome demonstrated 123 significantly (p < 0.05) differentially regulated proteins in CRSwNP relative to control. Eighty of these proteins overlapped with the matched CRSwNP tissue proteome as compared with only 4 among matched whole mucus samples. Forty‐three significantly dysregulated pathway networks overlapped between the exosomal and tissue proteome in CRSwNP as compared with only 3 among matched whole mucus samples. The best‐performing protein set (cystatin‐SN, peroxiredoxin‐5, and glycoprotein VI) achieved an area under the curve (AUC) value of up to 99%.ConclusionOur data contribute a significant advance in the development of a reproducible, noninvasive, serial, and quantitative “liquid biopsy” for rhinosinusitis. The exosomal proteomic approach has revealed a unique biosignature associated with CRSwNP, which outperforms whole mucus sampling, and thus provides a method of noninvasive disease detection and proposes new potential therapeutic targets.
LasDB: A collective database for laboratory animal strain resources
Authors: Kong Qi , Qin Chuan 
Published: November 2018

AbstractBackgroundWith the aim of establishing the most comprehensive database of laboratory animal strains, the “laboratory animal strain resources database” (LasDB) was constructed as a searchable online database of all laboratory animal strains, stocks and mutant embryonic stem‐cell lines available worldwide, including inbred, outbred, mutant and genetically engineered strains.MethodsMySQL database software was used to construct the LasDB, offering an easy‐to‐use interface.ResultsTo date, LasDB has a collection covering data for 21 596 mouse strains, 2062 rat strains, 13 monkey strains, 2 hamster strains, 5 dog strains, 5 rabbit strains and more than 50 other laboratory animal strains. LasDB will be continually improved with regular updates of new laboratory animal strains from all over the world.ConclusionTo the best of our knowledge, this is the first database that attempts to systematically integrate all available laboratory animal strain data with the aim of supporting open usage and full resource sharing.
Enhanced stability and propylene yield in methanol to light olefins conversion over nanostructured SAPO‐34/ZSM‐5 composite with various SAPO‐loadings
Authors: Mohammadkhani Bahman , Haghighi Mohammad , Aghaei Erfan 
Published: November 2018

AbstractNanostructured core‐shell silicoaluminophosphate (SAPO)‐34/zeolite socony mobil (ZSM)‐5 composite has been synthesized with various SAPO‐34 loadings in order to control light olefins selectivity and increase its lifetime in methanol to olefins process. Physicochemical properties and catalytic performance of SAPO‐34/ZSM‐5 composite catalyst were different, compared with the parent SAPO‐34 and ZSM‐5. As‐synthesized samples were characterized by different methods such as X‐Ray diffraction, field emission scanning electron microscopy, Brunauer–Emmett–Teller, energy‐dispersive X‐ray, Fourier transform infrared spectroscopy, and NH3‐temperature‐programmed desorption techniques. By increasing SAPO‐34 content in composite catalysts, relative crystallinity of CHA‐phase (chabazite) was enhanced, whereas it was decreased for MFI‐phase. Also, surface area improved by increasing SAPO‐34 loading in core‐shell composite catalysts. The results of the activity test showed that lifetime remarkably increased by using composite catalysts. Compared with the parent SAPO‐34 and ZSM‐5, the composite catalyst with 80% SAPO‐34 loading showed higher methanol conversion and olefins selectivity with time on stream. This is due to the synergic effect between SAPO‐34 and ZSM‐5 zeolites in composite catalyst.
SVD‐aided EKF attitude estimation with UD factorized measurement noise covariance
Authors: Cilden‐Guler Demet , Hajiyev Chingiz 
Published: November 2018

AbstractThis paper describes singular value decomposition (SVD) aided extended Kalman filter (EKF) for nanosatellite's attitude estimation. The development of the filter kinematic/dynamic model, the measurement models of the sun sensors, and the magnetometers used to generate vector measurements are presented. Vector measurements are used in SVD for satellite attitude determination purposes. In the proposed method, EKF inputs come from SVD as the linear measurements of attitude angles and their error covariance. In this step, UD factorizes the attitude angles error covariance, forming the measurements in order to obtain the appropriate inputs for the filtering stage. Results are presented and analyzed in addition to discussion of the sub‐step, which is the UD factorization on the measurement covariance. The accuracy of the estimation results of the SVD‐aided EKF with and without UD factorization is compared for estimation performance.
Effects of Tyr555 and Trp678 on the processivity of cellobiohydrolase A from Ruminiclostridium thermocellum: A simulation study
Authors: Han Fei , Liu Ye , E Jingwen , Guan Shanshan , Han Weiwei , Shan Yaming , Wang Song , Zhang Hao 
Published: November 2018

AbstractCellobiohydrolase A from Ruminiclostridium thermocellum (Cbh9A) is a processive exoglucanase from family 9 and is an important cellobiohydrolase that hydrolyzes cello‐oligosaccharide into cellobiose. Residues Tyr555 and Trp678 considerably affect catalytic activity, but their mechanisms are still unknown. To investigate how the Tyr555 and Trp678 affect the processivity of Cbh9A, conventional molecular dynamics, steered molecular dynamics, and free energy calculation were performed to simulate the processive process of wild type (WT)‐Cbh9A, Y555S mutant, and W678G mutant. Analysis of simulation results suggests that the binding free energies between the substrate and WT‐Cbh9A are lower than those of Y555S and W678G mutants. The pull forces and energy barrier in Y555S and W678G mutants also reduced significantly during the steered molecular dynamics (SMD) simulation compared with that of the WT‐Cbh9A. And the potential mean force calculations showed that the pulling energy barrier of Y555S and W678G mutants is much lower than that of WT‐Cbh9A.
Price of disorder in the lac repressor hinge helix
Authors: Seckfort Danielle , Montgomery Pettitt B. 
Published: November 2018

AbstractThe Lac system of genes has been pivotal in understanding gene regulation. When the lac repressor protein binds to the correct DNA sequence, the hinge region of the protein goes through a disorder to order transition. The structure of this region of the protein is well understood when it is in this bound conformation, but less so when it is not. Structural studies show that this region is flexible. Our simulations show this region is extremely flexible in solution; however, a high concentration of salt can help kinetically trap the hinge helix. Thermodynamically, disorder is more favorable without the DNA present.
Oxygen Electroreduction on Nanoporous Carbons: Textural Features vs Nitrogen and Boron Catalytic Centers
Authors: Florent Marc , Wallace Rajiv , Bandosz Teresa J. 
Published: November 2018

AbstractPorous carbons containing either B and N heteroatom (∼10 at.% each) or B‐ and N‐free were synthesized and used as ORR metal‐free catalysts. The number of electron transfer was close to 4 (3.94) regardless the presence or not of heteroatom‐based catalytic centers, and the onset potential reached 0.827 V (on Pt/C 0.888 V). The carbons were extensively characterized from the viewpoints of their surface chemistry and porosity. The results indicated that a high volume of small pores where oxygen can be strongly adsorbed enhances the ORR efficiency, positively affecting the number of electron transfer and the value of the onset potential. On carbons with moderate volume of ultramicropores, N and B catalytic centers compensate the porosity effect enhancing the performance. These two mechanisms of ORR can coexist leading to a very efficient process on metal free carbon‐based porous catalysts.
NaBArF4‐Catalyzed Oxidative Cyclization of 1,5‐ and 1,6‐Diynes: Efficient and Divergent Synthesis of Functionalized γ‐ and δ‐Lactams
Authors: Zhu Bo‐Han , Wang Cai‐Ming , Su Hong‐Yu , Ye Long‐Wu 
Published: November 2018

Summary of main observation and conclusionAn efficient NaBArF4‐catalyzed oxidative cyclization of readily available 1,5‐ and 1,6‐diynes has been developed. Importantly, this transition metal‐free oxidative catalysis proceeds via a presumable Lewis acid‐catalyzed SN2’ pathway, which is distinct from the relevant oxidative rhodium and gold catalysis. This method leads to the facile and practical construction of a diverse range of synthetically useful γ‐ and δ‐lactams in mostly good to excellent yields with broad substrate scope.
Engineering SpyCatcher Variants with Proteolytic Sites for Less‐Trace Ligation
Authors: Zhang Xue‐Jian , Wu Xia‐Ling , Liu Dong , Da Xiao‐Di , Wang Xiao‐Wei , Yang Shuguang , Zhang Wen‐Bin 
Published: November 2018

Summary of main observation and conclusionThe SpyTag/SpyCatcher reaction is a powerful tool for bioconjugation, but it leaves a complex of considerable size after ligation. To facilitate removal of the catalytic fragment, proteolytic recognition sites (such as DDDDK, AVLQ, and WELQ) were directly engineered into the first or second loop of SpyCatcher at locations after the reactive lysine to give a set of cleavable SpyCatcher variants. Among them, SpyCatcherDDDDK exhibits excellent reactivity with SpyTag and could still be cleaved proteolytically by enterokinase after ligation. Notably, SpyCatcherDDDDK is disordered in solution and forms an ordered complex upon reaction with SpyTag with a second order rate constant of 99.2 ± 0.1 M–1·s–1, which is comparable to, if not faster than, most click reactions. The results demonstrate the high sequence plasticity of SpyCatcher and suggest that covalent bond formation may confer robustness on the folded structure against extensive mutation. These variants add to the expanding toolbox of genetically‐encoded peptide‐protein chemistry with diverse features.
Total Synthesis of a Hyperbranched N‐Linked Hexasaccharide Attached to ATCV‐1 Major Capsid Protein without Precedent
Authors: Wang Yong‐Shi , Wu Yong , Xiong De‐Cai , Ye Xin‐Shan 
Published: November 2018

Summary of main observation and conclusionThe N‐glycans attached to some chloroviruses comprise a hyperbranched core structure without precedent. We are interested in the chemical synthesis of the hexasaccharide attached to ATCV‐1 (Acanthocystis turfacea Chlorella virus 1) for its distinct structure. After exploring four routes, the target hexasaccharide 2 was successfully synthesized for the first time in overall 10% yield over 8 steps from thioglycoside building blocks. This synthetic protocol is characterized by the three‐component one‐pot glycosylation and the regioselective glycosylation reactions. The disclosed synthetic approach to this new type of N‐glycans will facilitate the in‐depth understanding of their biological functions.
Identification of Pyrrolidine‐3‐acetic Acid Derived Oximes as Potent Inhibitors of γ‐Aminobutyric Acid Transporter 1 through Library Screening with MS Binding Assays
Authors: Huber Simone K. , Höfner Georg , Wanner Klaus T. 
Published: November 2018

AbstractIn this study, pyrrolidine‐3‐acetic acid derived oxime libraries were applied to the concept of library screening by MS Binding Assays, as a powerful technique to reveal new potent murine γ‐aminobutyric acid transporter subtype (mGAT1) inhibitors. Library generation was accomplished by condensation of an excess of pyrrolidine‐3‐acetic acid bearing a hydroxylamine unit with various libraries, each composed of eight different aldehydes. The oxime libraries have been screened by means of competitive MS Binding Assays and, as a consequence, the most active libraries were further investigated through deconvolution experiments to identify single oximes responsible for the observed activity on the target mGAT1. All identified hits were finally resynthesized to characterize them with respect to their binding affinities, and a set of new potent inhibitors with the pyrrolidine‐3‐acetic acid motif were found, of which the most potent oxime, possessing a 2′,4′‐dichlorobiphenyl residue, displayed a binding affinity in the low nanomolar range (pKi=7.87±0.01).
Improved Solar Energy Photoactivity over Defective BiOBr Ultrathin Nanosheets towards Pollutant Removal and Oxygen Evolution
Authors: Wu Weibin , Zhang Zhenbang , Di Jun , Zhao Wenfeng 
Published: November 2018

AbstractDefective BiOBr nanosheets with ultrathin thickness and surface‐confined pits have been synthesized through a dual control of cetyltrimethylammonium bromide (CTAB) and polyvinyl pyrrolidone (PVP). The photocatalytic activity of the obtained defective BiOBr nanosheets was evaluated for the removal of rhodamine B (RhB), ciprofloxacin (CIP) and oxygen evolution from water. The as‐prepared defective BiOBr nanosheets displayed significantly increased activity for pollutant degradation and oxygen evolution. The enhanced photocatalytic activity was ascribed to the improved light harvesting, suppression of charge recombination, and an increase in the number of active sites for photocatalytic reaction. The electronic structure of the defective BiOBr ultrathin nanosheets with confined pits has been tuned and thus varied the photocatalytic mechanism for pollutant degradation. The active species have changed from hole for BiOBr nanoplates to superoxide radical (O2.−) and hole for defective BiOBr nanosheets determined by ESR analysis and trapping experiments.
Microbial and inflammatory‐based salivary biomarkers of head and neck squamous cell carcinoma
Authors: Vesty Anna , Gear Kim , Biswas Kristi , Radcliff Fiona J. , Taylor Michael W. , Douglas Richard G. 
Published: November 2018

AbstractHead and neck squamous cell carcinoma (HNSCC) patients often present with poor oral health, making it difficult to assess the relationship between oral microbes, inflammation, and carcinoma. This study investigates salivary microbes and inflammatory cytokines as biomarkers for HNSCC, with consideration of oral health. Saliva was collected from 30 participants, including 14 HNSCC patients and 16 participants representing both dentally compromised and healthy individuals. Bacterial and fungal communities were analyzed based on 16S rRNA gene and ITS1 amplicon sequencing, respectively, and concentrations of inflammatory cytokines were quantified using a cytometric bead array, with flow cytometry. Diversity‐based analyses revealed that the bacterial communities of HNSCC patients were significantly different to those of the healthy control group but not the dentally compromised patients. Fungal communities were dominated by Candida, irrespective of cohort, with Candida albicans comprising ≥96% of fungal sequences in most HNSCC patients. Significantly higher concentrations of interleukin (IL)‐1β and IL‐8 were detected in HNSCC and dentally compromised patients, when independently compared with healthy controls. IL‐1β and IL‐8 concentrations were significantly positively correlated with the abundance of C. albicans. Our findings suggest that salivary microbial and inflammatory biomarkers of HNSCC are influenced by oral health.
Development of Alkali Nitrate‐Containing Li4SiO4 for High‐Temperature CO2 Capture
Authors: Wang Ke , Hong Jie , Zhou Zhongyun , Lin Zhiwei , Zhao Pengfei 
Published: November 2018

AbstractHigh efficiency alkali nitrate‐containing Li4SiO4 sorbents were synthesized by a hydration technique to improve their sorption performances at low CO2 concentrations. X‐ray diffraction (XRD), scanning electron microscopy (SEM), X‐ray photoelectron spectroscopy (XPS), differential scanning calorimetry (DSC), and thermogravimetric analyses were used to detect the characteristics of the samples. The results showed that the presence of KNO3 and NaNO3 induced small crystallite size, corrugated morphologies and the formation of eutectic phases, noticeably facilitating sorption processes. At the optimized additive amount of 0.035 mol %, NaNO3‐containing Li4SiO4 reached a maximum absorption capacity (≈34.6 wt %). Moreover, both alkali nitrate‐containing Li4SiO4 sorbents showed good cyclic properties, demonstrating their great potential for high‐temperature CO2 capture.
Walnut oil improves spatial memory in rats and increases the expression of acid‐sensing ion channel genes Asic2a and Asic4
Authors: Wang Li‐Mei , Yi Yang , Yao Yi‐Lan , Feng Ge , Shu Chang , Wang Hong‐Xun , Zhang Xi‐Feng 
Published: November 2018

AbstractAlthough Walnut oil (WO) has been reported to enhance cognitive function, the underlying molecular mechanisms are not well understood. This study was designed to assess the effects of WO on spatial memory in rats through modulation of the expression of acid‐sensing ion channel genes, Asic2a and Asic4. To investigate the effect of WO on cognitive performance, we supplemented the diet of female rats with WO. The results showed that supplementation with WO at doses of 2.2 and 11 g kg−1 day−1 significantly improved learning and memory. In vitro treatment of rat hippocampal neuronal cells with appropriate doses of WO revealed a significant increase in the expression of Asic2a and Asic4 in a dose‐dependent manner at both the mRNA and protein levels. We conclude that WO intake might help to prevent cognitive decline, particularly in the elderly, and that ASIC genes in neurons can be the targets of compounds contained in the oil.
Late Carboniferous southward migration of Tarbagatay subduction–accretion complex by slab retreat and break‐off in West Junggar (NW China)
Authors: Borbugulov Esen , Chen Yichao , Xiao Wenjiao , Windley Brian F. , Schulmann Karel , Zhang Ji'en , Zhang Zhiyong , Song Shuaihua , Li Rui , Sang Miao 
Published: November 2018

The Carboniferous tectonic history of the northern West Junggar of NW China is of key importance for understanding the tectonics of the Altaids. This paper presents a systematic study of the emplacement of the E'min ophiolite, the ages of turbidites, and a stitching granite dike in order to constrain the late Carboniferous oceanic evolution of northern West Junggar. Our field investigation reveals that the Tarbagatay subduction–accretion complex formed by imbrication of turbidites and ophiolitic slices in the Western Tarbagatay Mountain, which is considered as the forearc of the Saur arc in northern West Junggar. Field relationships and zircon geochronology suggest that the emplacement of the E'min ophiolite was later than the minimum time of deposition of hanging wall turbidites, which have a zircon age of 324 Ma, and must be earlier than the crystallization time of a 311‐Ma stitching granite dike that intruded the younger turbidites. The turbidites become younger from north to south, with minimum deposition ages varying from 324 to 309 Ma. The 311‐Ma dike has an adakitic affinity suggesting that it may have formed by magma melted from a subduction slab wedge and from accreted material at ~310 Ma. Therefore, we propose an accretionary arc setting for the Saur arc, with southward migration of the trench and magma front. The 311‐Ma dike has a high Al enrichment and arc‐related geochemical signature suggesting that it was generated by melting of accreted trench sediments. This may indicate that subduction of the Saur arc may have lasted to at least the late Carboniferous. The development of such arc accretion suggests that the formation of the southern Altaids was fundamentally similar to that of accretionary orogens in the western Pacific.