bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic accuracy of dopaminergic imaging in prodromal dementia with Lewy bodies
Authors: Thomas Alan J. , Donaghy Paul , Roberts Gemma , Colloby Sean J. , Barnett Nicky A. , Petrides George , Lloyd Jim , Olsen Kirsty , Taylor John-Paul , McKeith Ian , O'Brien John T. 
Published: April 2018

AbstractBackgroundDopaminergic imaging has high diagnostic accuracy for dementia with Lewy bodies (DLB) at the dementia stage. We report the first investigation of dopaminergic imaging at the prodromal stage.MethodsWe recruited 75 patients over 60 with mild cognitive impairment (MCI), 33 with probable MCI with Lewy body disease (MCI-LB), 15 with possible MCI-LB and 27 with MCI with Alzheimer's disease. All underwent detailed clinical, neurological and neuropsychological assessments and FP-CIT [123I-N-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)] dopaminergic imaging. FP-CIT scans were blindly rated by a consensus panel and classified as normal or abnormal.ResultsThe sensitivity of visually rated FP-CIT imaging to detect combined possible or probable MCI-LB was 54.2% [95% confidence interval (CI) 39.2–68.6], with a specificity of 89.0% (95% CI 70.8–97.6) and a likelihood ratio for MCI-LB of 4.9, indicating that FP-CIT may be a clinically important test in MCI where any characteristic symptoms of Lewy body (LB) disease are present. The sensitivity in probable MCI-LB was 61.0% (95% CI 42.5–77.4) and in possible MCI-LB was 40.0% (95% CI 16.4–67.7).ConclusionsDopaminergic imaging had high specificity at the pre-dementia stage and gave a clinically important increase in diagnostic confidence and so should be considered in all patients with MCI who have any of the diagnostic symptoms of DLB. As expected, the sensitivity was lower in MCI-LB than in established DLB, although over 50% still had an abnormal scan. Accurate diagnosis of LB disease is important to enable early optimal treatment for LB symptoms.
Social Insurance as Fiscal Policy and State-Building Tool: The Development and Politics of Payroll Contributions in Israel and Canada
Authors: BÉLAND DANIEL , KOREH MICHAL 
Published: April 2018

AbstractThe scholarship on state-building has devoted a significant amount of attention to the role of taxation in building state institutions and capacities. It has also emphasised the crucial role of taxation in driving state-society relations. Scholars have argued that the linkage between taxation and state building also applies to the area of social policy. In this paper, we draw on a fiscal-centred perspective on welfare state development that highlights the fiscal policy role of social insurance as a revenue raising institution to study the fiscal relationship between social insurance and state-building in Israel and Canada – two ‘most dissimilar cases’ that nonetheless feature strikingly similar patterns with regard to this relationship. As our findings show, in both cases, social insurance programmes were introduced, designed, and utilized to advance fiscal and economic policy capacity and thereby promote state building. Using these programmes and the commitments they created, political actors could legitimize the generation of revenues, build institutional infrastructure for tax collection, and create capital reserves for investing in the economy.
APOEε4 and the long arm of social inequity: estimated effects of socio-economic status and sex on the timing of dementia onset
Authors: HASSELGREN CAROLINE , EKBRAND HANS , FÄSSBERG MADELEINE MELLQVIST , ZETTERGREN ANNA , ZETTERBERG HENRIK , BLENNOW KAJ , SKOOG INGMAR , HALLERÖD BJÖRN 
Published: April 2018

ABSTRACTIt is well established that carriers of the apolipoprotein E (APOE) ε4 allele run a greater risk of developing Alzheimer's disease, the most common form of dementia and a strongly age-related condition known to disproportionally affect women. Low educational attainment also stands out as a prominent risk factor, and it has been suggested that occupational class plays a similar role in disease susceptibility. Not yet fully explored, however, is the question of whether socio-economic status (SES) could moderate the effect ofAPOEε4. In the present paper, we address this issue. As substantial inequities in workforce participation and educational opportunities have existed between men and women in previous generations, we further examine whether SES-related moderations of the relationship between dementia andAPOEε4 are sex-specific. Our analyses are based on a sample of 580 individuals from the H70 Birth Cohort Study and the Prospective Population Study on Women in Gothenburg, Sweden. Data were analysed using Cox proportional hazards regression, and the results suggest that while high SES postpones dementia onset among maleAPOEε4 carriers, this is not the case for women. These findings underscore the long-term impact of social inequity on health as well as the importance of considering potential interactions between social and genetic risk factors if we are to understand better the complex aetiology of dementia.
Human to humanoid motion conversion for dual-arm manipulation tasks
Authors: Tomić Marija , Chevallereau Christine , Jovanović Kosta , Potkonjak Veljko , Rodić Aleksandar 
Published: April 2018

SUMMARYA conversion process for the imitation of human dual-arm motion by a humanoid robot is presented. The conversion process consists of an imitation algorithm and an algorithm for generating human-like motion of the humanoid. The desired motions in Cartesian and joint spaces, obtained from the imitation algorithm, are used to generate the human-like motion of the humanoid. The proposed conversion process improves existing techniques and is developed with the aim to enable imitating of human motion with a humanoid robot, to perform a task with and/or without contact between hands and equipment. A comparative analysis shows that our algorithm, which takes into account the situation of marker frames and the position of joint frames, ensures more precise imitation than previously proposed methods. The results of our conversion algorithm are tested on the robot ROMEO through a complex “open/close drawer” task.
Tropical forest dynamics in unstable terrain: a case study from New Guinea
Authors: Vincent John B. , Turner Benjamin L. , Alok Clant , Novotny Vojtech , Weiblen George D. , Whitfeld Timothy J. S. 
Published: April 2018

Abstract:Long-term forest dynamics plots in the tropics tend to be situated on stable terrain. This study investigated forest dynamics on the north coast of New Guinea where active subduction zones are uplifting lowland basins and exposing relatively young sediments to rapid weathering. We examined forest dynamics in relation to disturbance history, topography and soil nutrients based on partial re-census of the 50-ha Wanang Forest Dynamics Plot in Papua New Guinea. The plot is relatively high in cations and phosphorus but low in nitrogen. Soil nutrients and topography accounted for 29% of variation in species composition but only 4% of variation in basal area. There were few areas of high biomass and most of the forest was comprised of small-diameter stems. Approximately 18% of the forest was less than 30 y old and the annual tree mortality rate of nearly 4% was higher than in other tropical forests in South-East Asia and the neotropics. These results support the reputation of New Guinea's forests as highly dynamic, with frequent natural disturbance. Empirical documentation of this hypothesis expands our understanding of tropical forest dynamics and suggests that geomorphology might be incorporated in models of global carbon storage especially in regions of unstable terrain.
Sharp decay estimates in a bioconvection model with quadratic degradation in bounded domains
Authors: Cao Xinru , Winkler Michael 
Published: April 2018

The paper studies large time behaviour of solutions to the Keller–Segel system with quadratic degradation in a liquid environment, as given byunder Neumann boundary conditions in a bounded domain Ω ⊂ ℝn, where n ≥ 1 is arbitrary. It is shown that whenever U : Ω × (0,∞) → ℝn is a bounded and sufficiently regular solenoidal vector field any non-trivial global bounded solution of (⋆) approaches the trivial equilibrium at a rate that, with respect to the norm in either of the spaces L1(Ω) and L∞(Ω), can be controlled from above and below by appropriate multiples of 1/(t + 1). This underlines that, even up to this quantitative level of accuracy, the large time behaviour in (⋆) is essentially independent not only of the particular fluid flow, but also of any effect originating from chemotactic cross-diffusion. The latter is in contrast to the corresponding Cauchy problem, for which known results show that in the n = 2 case the presence of chemotaxis can significantly enhance biomixing by reducing the respective spatial L1 norms of solutions.
Aurangzeb in the Perspective of Kachvāhā Literature
Authors: HORSTMANN MONIKA 
Published: April 2018

AbstractThe literary and genealogical accounts produced at the Kachvāhā court of Jaipur, addressing the relationship between Aurangzeb and the Kachvāhās, post-date Aurangzeb. Three of these are introduced, one of them in Sanskrit, two vernacular. While all these writings are informed by archival records, they serve the end of glorifying Kachvāhā kingship as it had started visibly defying Mughal authority from the late 1660s. The last of these accounts was written in the middle of the nineteenth century, when Jaipur was a British protectorate, and reflects an attempt to represent the sum total of Kachvāhā Rajput ethos and history at the critical point when the Jaipur state was overhauled by administrative reforms.
Acting for God? Types and Motivations of Clergy Political Activity
Authors: Glazier Rebecca A. 
Published: April 2018

AbstractClergy members are often important political actors. Yet, scholars rarely distinguish among different types of clergy political activities. Here, I argue for three disaggregated categories of clergy political activity: personal, general congregation level, and election-specific congregation level. Data from two sources—the Cooperative Clergy Study and the Little Rock Congregations Study—demonstrate that important differences exist across these categories, with the majority of model variables significantly influencing different clergy political activitiesin different directions. For instance, a conservative ideology and affiliation with a Black Protestant church both negatively influence personal political activities, like donating to a campaign, while also positively influencing election-related political activities in the congregation, like distributing voter guides. Similarly, providential religious beliefs increase general congregation-level political activities, while decreasing personal and electoral activities. These relationships are obscured when political activity is considered in the aggregate, suggesting that clergy political activities are nuanced; different activities are driven by different motivations.
Isolating the direct effects of adverse developmental conditions on in vivo cardiovascular function at adulthood: the avian model
Authors: Skeffington K. L. , Beck C. , Itani N. , Giussani D. A. 
Published: April 2018

AbstractIt is now well accepted that exposure to adverse environmental conditions in utero can predispose a fetus to disease later in life. Using an avian model to study the programming of disease has a unique advantage as it allows isolation of the direct effects of adverse conditions on fetal physiology, without any confounding effects via the mother or placenta. However, experiments in avian models are limited by the lack of well-established surgical protocols for the adult bird, which we have established in this study. Surgery was performed on seven young adult Bovan Brown chickens (body weight 1617±214 g, mean±s.d.) in order to instrument them with femoral arterial and venous catheters and a femoral arterial flow probe. Isoflurane and lidocaine were both found to have depressive effects on chicken cardiovascular function. Optimised methods of anaesthesia, intraoperative monitoring, surgical approach, postoperative care, and experimentation are described. Chickens recovered rapidly from surgery without significant blood gas perturbation, and basal in vivo cardiovascular studies were performed following 5 days of recovery. These techniques allow detailed investigation of avian cardiometabolic function, permitting determination of the consequences in later life of direct environmental insults to fetal physiology, isolated from additional effects on maternal physiology and/or placental endocrinology.
Autonomic reinnervation and functional regeneration in autologous transplanted submandibular glands in patients with severe keratoconjunctivitis sicca
Authors: Zhang Xueming , Yang Ningyan , Liu Xiaojing , Su Jiazeng , Cong Xin , Wu Liling , Zhang Yan , Yu Guangyan 
Published: April 2018

AbstractAutologous submandibular gland (SMG) transplantation has been proved to ameliorate the discomforts in patients with severe keratoconjunctivitis sicca. The transplanted glands underwent a hypofunctional period and then restored secretion spontaneously. This study aims to investigate whether autonomic nerves reinnervate the grafts and contribute to the functional recovery, and further determine the origin of these nerves. Parts of the transplanted SMGs were collected from the epiphora patients, and a rabbit SMG transplantation model was established to fulfill the serial observation on the transplanted glands with time. The results showed that autonomic nerves distributed in the transplanted SMGs and parasympathetic ganglionic cells were observed in the stroma of the glands. Low-dense and unevenly distributed cholinergic axons, severe acinar atrophy and fibrosis were visible in the patients’ glands 4–6 months post-transplantation, whereas the cholinergic axon density and acinar area were increased with time. The acinar area or the secretory flow rate of the transplanted glands was statistically correlated with the cholinergic axon density in the rabbit model, respectively. Meanwhile, large cholinergic nerve trunks were found to locate in the temporal fascia lower to the gland, and sympathetic plexus concomitant with the arteries was observed both in the adjacent fascia and in the stroma of the glands. In summary, the transplanted SMGs are reinnervated by autonomic nerves and the cholinergic nerves play a role in the morphological and functional restoration of the glands. Moreover, these autonomic nerves might originate from the auriculotemporal nerve and the sympathetic plexus around the supplying arteries.
High orange juice consumption with or in-between three meals a day differently affects energy balance in healthy subjects
Authors: Hägele Franziska A , Büsing Franziska , Nas Alessa , Aschoff Julian , Gnädinger Lena , Schweiggert Ralf , Carle Reinhold , Bosy-Westphal Anja 
Published: April 2018

AbstractSugar-containing beverages like orange juice can be a risk factor for obesity and type 2 diabetes although the underlying mechanisms are less clear. We aimed to investigate if intake of orange juice with or in-between meals differently affects energy balance or metabolic risk. Twenty-six healthy adults (24.7 ± 3.2 y; BMI 23.2 ± 3.2 kg/m2) participated in a 4-week cross-over intervention and consumed orange juice (20% of energy requirement) either together with 3 meals/d (WM) or in-between 3 meals/d (BM) at ad libitum energy intake. Basal and postprandial insulin sensitivity (primary outcome), daylong glycaemia, glucose variability and insulin secretion were assessed. Body fat mass was measured by air-displacement plethysmography. After BM-intervention, fat mass increased (+1.0 ± 1.8 kg; p < 0.05) and postprandial insulin sensitivity tended to decrease (ΔMatsudaISI: −0.89 ± 2.3; p = 0.06). By contrast, after WM-intervention fat mass and gamma-glutamyl transferase (GGT) decreased (−0.30 ± 0.65 kg; −2.50 ± 3.94; both p < 0.05), whereas glucose variability was higher (ΔMAGE: +0.45 ± 0.59, p < 0.05). Daylong glycaemia, insulin secretion, changes in basal insulin sensitivity, and triglycerides did not differ between WM- and BM-interventions (all p > 0.05). In young healthy adults, a conventional 3-meal structure with orange juice consumed together with meals had a favorable impact on energy balance, whereas juice consumption in-between meals may contribute to a gain in body fat and adverse metabolic effects.
Longitudinal association between egg consumption and the risk of cardiovascular disease: interaction with type 2 diabetes mellitus
Authors: Jang Jiyoung , Shin Min-Jeong , Kim Oh Yoen , Park Kyong 
Published: April 2018

Abstract
Background/objectives
It remains unclear if high egg consumption has beneficial or adverse effects on cardiometabolic health. The present study prospectively evaluated the longitudinal association between egg-consumption levels and incident cardiovascular disease (CVD) among Korean adults.

Subjects/methods
We conducted a prospective cohort study of 9248 Korean adults aged 40–69 years without CVD or cancer at the baseline from the Korean Genome and Epidemiology Study, Ansung–Ansan cohort, South Korea. The egg intake of the participants was estimated using a validated semiquantitative food frequency questionnaire at the baseline and the second follow-up examination and categorized into quartiles. CVD cases were identified using biennial questionnaires and confirmed through repeated in-depth personal interviews. Hazard ratios (HR) and 95% confidence interval (CI) were analyzed using Cox proportional hazard regression.

Results
During the average follow-up of 7.3 years, 570 cases of CVD were newly diagnosed. After adjusting for multiple confounding variables, egg-intake levels were not associated with CVD incidence (HR: 1.14, 95% CI: 0.87–1.49, P for trend: 0.7). However, the association was modified by type 2 diabetes mellitus (T2DM) status. Egg consumption was significantly associated with an increased risk for incident CVD among participants with T2DM; individuals with the highest egg intake (4.2 ± 0.04 eggs/week) had a 2.8 times higher incidence of CVD (HR: 2.81, 95% CI: 1.25–6.30, P for trend: 0.02) than those with the lowest egg intake (0.1 ± 0.02 eggs/week). However, no association was observed among individuals without T2DM (HR: 1.03, 95% CI: 0.77–1.38, P for trend: 0.8).

Conclusions
Higher egg consumption may increase the risk for CVD in Korean patients with T2DM. Our findings provide a basis for the development of an optimal dietary cholesterol intake guideline for the Korean population.
Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts
Authors: Sun Jun , Ermann Joerg , Niu Ningning , Yan Guang , Yang Yang , Shi Yujiang , Zou Weiguo 
Published: April 2018

AbstractMultiple regulatory mechanisms control osteoblast differentiation and function to ensure unperturbed skeletal formation and remodeling. In this study we identify histone lysine-specific demethylase 1(LSD1/KDM1A) as a key epigenetic regulator of osteoblast differentiation. Knockdown of LSD1 promoted osteoblast differentiation of human mesenchymal stem cells (hMSCs) in vitro and mice lacking LSD1 in mesenchymal cells displayed increased bone mass secondary to accelerated osteoblast differentiation. Mechanistic in vitro studies revealed that LSD1 epigenetically regulates the expression of WNT7B and BMP2. LSD1 deficiency resulted in increased BMP2 and WNT7B expression in osteoblasts and enhanced bone formation, while downregulation of WNT7B- and BMP2-related signaling using genetic mouse model or small-molecule inhibitors attenuated bone phenotype in vivo. Furthermore, the LSD1 inhibitor tranylcypromine (TCP) could increase bone mass in mice. These data identify LSD1 as a novel regulator of osteoblast activity and suggest LSD1 inhibition as a potential therapeutic target for treatment of osteoporosis.
Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance
Authors: Yan Bin , Liu Shuang , Shi Ying , Liu Na , Chen Ling , Wang Xiang , Xiao Desheng , Liu Xiaoli , Mao Chao , Jiang Yiqun , Lai Weiwei , Xin Xing , Tang Can-E , Luo Dixian , Tan Tan , Jia Jiantao , Liu Yating , Yang Rui , Huang Jun , Zhou Hu , Cheng Yan , Cao Ya , Yu Weishi , Muegge Kathrin , Tao Yongguang 
Published: April 2018

Abstract
Most cancer patients receive radiotherapy in the course of their disease and the occurrence of radioresistance is associated with poor prognosis. The molecular pathways that drive enhanced tumorigenic potential during the development of radioresistance are poorly understood. Here, we demonstrate that aryl hydrocarbon receptor (AhR) plays a vital role in the maintenance of cancer stem-like properties. AhR promotes the cancer stem-like phenotype and drives metastasis by directly targeting the promoters of ‘stemness’ genes, such as the ATP-binding cassette sub-family G member 2 (ABCG2) gene. Moreover, the radioresistant sublines display high levels of oncometabolites including α-ketoglutarate, and treatment of cancer cells with α-ketoglutarate enhances their stem-like properties in an AhR activation-dependent manner. IKKα directly activates stemness-related genes through an interaction with AhR as a bone fide chromatin modifier. Thus, AhR is functionally linked with cancer stem-like properties, and it drives tumorigenesis in the occurrence of radioresistance.
Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy
Authors: Fabbrizi Maria Rita , Meyer Barbara , Misri Sandeep , Raj Suyash , Zobel Cheri L. , Hallahan Dennis E. , Sharma Girdhar G. 
Published: April 2018

AbstractUnintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging. Stem cells exhibit attenuated DNA damage response (DDR) and are hypersensitive to IR, as compared to differentiated non-stem cells. We performed genomic discovery research to compare stem cells to differentiated cells, which revealed Phosphoprotein phosphatase 2A (PP2A) as a potential contributor to susceptibility in stem cells. PP2A dephosphorylates pATM, γH2AX, pAkt etc. and is believed to play dual role in regulating DDR and apoptosis. Although studied widely in cancer cells, the role of PP2A in normal stem cell radiosensitivity is unknown. Here we demonstrate that constitutively high expression and radiation induction of PP2A in stem cells plays a role in promoting susceptibility to irradiation. Transient inhibition of PP2A markedly restores DNA repair, inhibits apoptosis, and enhances survival of stem cells, without affecting differentiated non-stem and cancer cells. PP2Ai-mediated stem cell radioprotection was demonstrated in murine embryonic, adult neural, intestinal, and hematopoietic stem cells.