bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Just because I’m old it doesn’t mean I have to be fat’: a qualitative study exploring older adults’ views and experiences of weight management
Authors: Jackson Sarah E , Holter Linn , Beeken Rebecca J 
Published: February 2019

ObjectivesThe aim of this study was to explore older adults’ beliefs about the appropriateness of weight management, and how their experiences and expectations of weight management have changed as they have got older.DesignQualitative semistructured interview study.SettingUK.ParticipantsOlder adults (≥65 years) in the UK who had recent (<5 years) experience of trying to manage their weight (n=15; 12 women; 73% white British).ResultsData were analysed using thematic analysis. Emergent themes highlighted that weight remained a concern for many older adults, although having a high body weight was seen to be more acceptable at older than younger ages. Excess weight was reported to have negative consequences for health and well-being which participants felt could be alleviated by losing weight. Participants were motivated to lose weight for appearance and health reasons, but mentioned finding it harder to lose weight as they had got older and generally felt they had received limited guidance on weight management from health professionals.ConclusionsThe views of our participants highlight the need for further research into safe and effective methods of weight loss for older people and indicate that advice and support from health professionals would be welcomed.
Precarious employment, business performance and occupational injuries: a study protocol of a register-based Swedish project
Authors: Orellana Cecilia , Kreshpaj Bertina , Johansson Gun , Burström Bo , Kjellberg Katarina , Hemmingsson Tomas , Axén Magnus , Davis Letitia , Wegman David , Bodin Theo 
Published: February 2019

IntroductionThere is uncertainty regarding the trends in occupational injuries (OIs) in Sweden due to a significant and increasing problem with under-reporting to injury registers. Under-reporting, in general, is likely to be exacerbated by the rise in precarious employment (PE), a set of unfavourable employment characteristics that would benefit from formal definition and study. PE and global trends are believed also to affect companies and their commitment to health and safety. The present study attempts to bridge these knowledge gaps and presents a study protocol for planned studies, with three main objectives: first, to review the literature for definitions of PE emphasising those that are multidimensional and operationalise components in routinely collected register data; second, to estimate the under-reporting of OI in Swedish registers and third, using results from the first objective, to conduct large, register-based prospective studies, designed to measure effect sizes and interactions between PE, business performance and OI.Methods and analysisFirst, a scientific literature review will be conducted, including scientific databases and grey literature. Second, data from two major OI registers will be used to estimate the magnitude of under-reporting using capture–recapture methodology. Finally, all residents aged 18–65 in Sweden with any registered income during 2003–2015 will be included. Data sources encompass Swedish population and labour market registers with linkage to both the main OI register with national coverage and hospital records. Trends in PE and OI will be explored, together with risk of OI associated with PE and business performance.Ethics and disseminationThe project has been approved by the Regional Ethics Committee, Stockholm (dnr: 2016/2325–31; 2017/2173–32). Dissemination of study results will include a series of peer-reviewed papers, at least one PhD thesis and one report in Swedish, engaging relevant stakeholders. Results will be presented in national and international conferences and through press releases to mass media.
New rhombiferan blastozoans (Echinodermata) from the Late Ordovician of Morocco
Authors: Zamora Samuel , Nardin Elise , Esteve Jorge , Gutiérrez-Marco Juan Carlos 
Published: February 2019

Abstract

New Upper Ordovician Echinoderm–Lagerstätten from the Anti-Atlas of Morocco have provided large collections of blastozoan echinoderms. The echinosphaeritid
Echinosphaerites dianae
n. sp. preserves the oral region, stem and brachioles, characteristics absent in many species of the same genus.
Homocystites adidiensis
n. sp. is represented by almost 50 specimens that provide details on the growth in this taxon. This is the only species of
Homocystites
with granules in the external ridge of the outer proximal stem columnals. The genus
Rhombifera
is recognized for the first time in Morocco based on one partially preserved thecal plate. Assemblages are characterized by low diversity of rhombiferan blastozoan echinoderms that provide further palaeogeographical links at genus level with Gondwana, Baltica and Avalonia.
The dual origin of I-type granites: the contribution from experiments
Authors: Castro Antonio 
Published: February 2019

Abstract

New laboratory experiments using granulite xenoliths support a dual origin for I-type granites as primary and secondary. Primary I-type granites represent fractionated liquids from intermediate magma systems of broadly andesitic composition. Fluid-fluxed melting of igneous rocks that resided in the continental crust generates secondary I-type granites. The former are directly related to subduction, with Cordilleran batholiths as the most characteristic examples. Experiments with lower crust granulite sources, in the presence of water, show that amphibole is formed by a water-fluxed
peritectic rehydration melting reaction
. Entrainment of only 10% of restites composed of amphibole, pyroxene, plagioclase and magnetite, is sufficient to account for discrepancies in aluminium saturation index and maficity in secondary I-type granites. Lower crust granulite xenoliths, attached to a sanukitoid containing 6 wt% water, have been used in two-layer capsules to test fluid-fluxed melting reactions as the origin of secondary I-type granites. It is proposed that sanukitoid magmas act as water donors that trigger extensive melting of the lower crust, giving rise to granodioritic liquids. Because primary granites are related to coeval subduction, and secondary ones are crustal melts from older subduction-related rocks, the distinction between both I-types is essential in tectonic reconstructions of ancient orogenic belts.
Whole-rock geochemical modelling of granite genesis: the current state of play
Authors: Janoušek Vojtěch , Moyen Jean-François 
Published: February 2019

Abstract
Whole-rock geochemistry represents a powerful tool in deciphering petrogenesis of magmatic suites, including granitoids, which can be used to formulate and test hypotheses qualitatively and often also quantitatively. Typically, it can rule out impossible/improbable scenarios and further constrain the process inferred on geological and petrological grounds. With the current explosion of high-precision data, both newly acquired and retrieved from extensive databases, the whole-rock geochemistry-based petrogenetic modelling of igneous rocks will gain further importance. Especially promising is its combination with thermodynamic modelling into a single, coherent and comprehensive software, using the R and Python languages.
TDDFS
Authors: Cao Zhichao , Wen Hao , Ge Xiongzi , Ma Jingwei , Diehl Jim , Du David H. C. 
Published: February 2019

With the rapid increase in the amount of data produced and the development of new types of storage devices, storage tiering continues to be a popular way to achieve a good tradeoff between performance and cost-effectiveness. In a basic two-tier storage system, a storage tier with higher performance and typically higher cost (the fast tier) is used to store frequently-accessed (active) data while a large amount of less-active data are stored in the lower-performance and low-cost tier (the slow tier). Data are migrated between these two tiers according to their activity. In this article, we propose a Tier-aware Data Deduplication-based File System, called TDDFS, which can operate efficiently on top of a two-tier storage environment.
Specifically, to achieve better performance, nearly all file operations are performed in the fast tier. To achieve higher cost-effectiveness, files are migrated from the fast tier to the slow tier if they are no longer active, and this migration is done with data deduplication. The distinctiveness of our design is that it maintains the non-redundant (unique) chunks produced by data deduplication in both tiers if possible. When a file is reloaded (called a reloaded file) from the slow tier to the fast tier, if some data chunks of the file already exist in the fast tier, then the data migration of these chunks from the slow tier can be avoided. Our evaluation shows that TDDFS achieves close to the best overall performance among various file-tiering designs for two-tier storage systems.
Acquisition of a precision walking skill and the impact of proprioceptive deficits in people with motor-incomplete spinal cord injury
Authors: Chisholm Amanda E. , Qaiser Taha , Williams Alison M. M. , Eginyan Gevorg , Lam Tania 
Published: February 2019

Many people with motor-incomplete spinal cord injury (m-iSCI) experience difficulty navigating obstacles, such as curbs and stairs. The ability to relearn walking skills may be limited by proprioceptive deficits. The purpose of this study was to determine the capacity of participants to acquire a precision walking skill, and to evaluate the influence of proprioceptive deficits on the skill acquisition in individuals with m-iSCI. Sixteen individuals with m-iSCI and eight controls performed a precision walking task that required matching their foot height to a target during the swing phase. Proprioceptive deficits were quantified at the hip and knee for joint position and movement detection sense. Participants completed 600 steps of training with visual feedback. Pretraining and posttraining tests were conducted without visual feedback, along with a transfer test with an ankle weight. Posttraining and transfer tests were repeated 1 day later. Participants returned to the laboratory 1 wk later to repeat the training. Performance was calculated as the vertical distance between the target and actual foot height for each step. The posttraining and transfer performances were similar between groups. However, participants with m-iSCI had a slower rate of acquisition to achieve a similar performance level compared with controls. Acquisition rate and posttraining performance of the precision walking task were related to lower limb joint position sense among SCI participants. Although they can achieve a similar level of performance in a precision walking task, proprioceptive deficits impair the rate of learning among individuals with m-iSCI compared with able-bodied controls. NEW & NOTEWORTHY People with motor-incomplete spinal cord injuries are able to achieve the same level of performance accuracy on a precision walking task as able-bodied controls; however, the rate of learning is slower, indicating that more practice is required to stabilize performance. Our findings also show a relationship between impaired sensory function and reduced accuracy when performing a precision walking task after spinal cord injury.
Distinct types of neural reorganization during long-term learning
Authors: Zhou Xiao , Tien Rex N. , Ravikumar Sadhana , Chase Steven M. 
Published: February 2019

What are the neural mechanisms of skill acquisition? Many studies find that long-term practice is associated with a functional reorganization of cortical neural activity. However, the link between these changes in neural activity and the behavioral improvements that occur is not well understood, especially for long-term learning that takes place over several weeks. To probe this link in detail, we leveraged a brain-computer interface (BCI) paradigm in which rhesus monkeys learned to master nonintuitive mappings between neural spiking in primary motor cortex and computer cursor movement. Critically, these BCI mappings were designed to disambiguate several different possible types of neural reorganization. We found that during the initial phase of learning, lasting minutes to hours, rapid changes in neural activity common to all neurons led to a fast suppression of motor error. In parallel, local changes to individual neurons gradually accrued over several weeks of training. This slower timescale cortical reorganization persisted long after the movement errors had decreased to asymptote and was associated with more efficient control of movement. We conclude that long-term practice evokes two distinct neural reorganization processes with vastly different timescales, leading to different aspects of improvement in motor behavior. NEW & NOTEWORTHY We leveraged a brain-computer interface learning paradigm to track the neural reorganization occurring throughout the full time course of motor skill learning lasting several weeks. We report on two distinct types of neural reorganization that mirror distinct phases of behavioral improvement: a fast phase, in which global reorganization of neural recruitment leads to a quick suppression of motor error, and a slow phase, in which local changes in individual tuning lead to improvements in movement efficiency.
Neurally constrained modeling of speed-accuracy tradeoff during visual search: gated accumulation of modulated evidence
Authors: Servant Mathieu , Tillman Gabriel , Schall Jeffrey D. , Logan Gordon D. , Palmeri Thomas J. 
Published: February 2019

Stochastic accumulator models account for response times and errors in perceptual decision making by assuming a noisy accumulation of perceptual evidence to a threshold. Previously, we explained saccade visual search decision making by macaque monkeys with a stochastic multiaccumulator model in which accumulation was driven by a gated feed-forward integration to threshold of spike trains from visually responsive neurons in frontal eye field that signal stimulus salience. This neurally constrained model quantitatively accounted for response times and errors in visual search for a target among varying numbers of distractors and replicated the dynamics of presaccadic movement neurons hypothesized to instantiate evidence accumulation. This modeling framework suggested strategic control over gate or over threshold as two potential mechanisms to accomplish speed-accuracy tradeoff (SAT). Here, we show that our gated accumulator model framework can account for visual search performance under SAT instructions observed in a milestone neurophysiological study of frontal eye field. This framework captured key elements of saccade search performance, through observed modulations of neural input, as well as flexible combinations of gate and threshold parameters necessary to explain differences in SAT strategy across monkeys. However, the trajectories of the model accumulators deviated from the dynamics of most presaccadic movement neurons. These findings demonstrate that traditional theoretical accounts of SAT are incomplete descriptions of the underlying neural adjustments that accomplish SAT, offer a novel mechanistic account of decision-making mechanisms during speed-accuracy tradeoff, and highlight questions regarding the identity of model and neural accumulators. NEW & NOTEWORTHY A gated accumulator model is used to elucidate neurocomputational mechanisms of speed-accuracy tradeoff. Whereas canonical stochastic accumulators adjust strategy only through variation of an accumulation threshold, we demonstrate that strategic adjustments are accomplished by flexible combinations of both modulation of the evidence representation and adaptation of accumulator gate and threshold. The results indicate how model-based cognitive neuroscience can translate between abstract cognitive models of performance and neural mechanisms of speed-accuracy tradeoff.
Analysis of upper threshold mechanisms of spherical neurons during extracellular stimulation
Authors: Fellner Andreas , Stiennon Isabel , Rattay Frank 
Published: February 2019

Exceeding a certain stimulation strength can prevent the generation of somatic action potentials, as has been demonstrated in vitro with extracellularly stimulated dorsal root ganglion cells as well as retinal ganglion cells. This phenomenon, termed upper threshold, is currently thought to be a consequence of sodium current reversal in strongly depolarized regions. Here we analyze the contribution of membrane kinetics, using spherical model neurons that are stimulated externally with a microelectrode, in more detail. During extracellular pulse application, the electric field depolarizes one part and hyperpolarizes the other part of the cell. Strong transmembrane currents are generated only in the active depolarized region, changing the overall polarization level. The asymmetric membrane voltage distribution caused by the stimulus strongly influences the cell’s behavior during and even after the stimulus. Effects on membrane voltage and transmembrane currents during and after the stimulus are shown and discussed in detail. Aside from the sodium current reversal, two more key mechanisms were identified in causing the upper threshold: strong potassium currents and inactivation of sodium channels. The contributions of the mechanisms involved strongly depend on cell properties, stimulus parameters, and other factors such as temperature. The conclusions presented here are based on several retinal ganglion cell models of the Fohlmeister group, a model with original Hodgkin-Huxley membrane, and a pyramidal cell model. NEW & NOTEWORTHY The upper threshold phenomenon in extracellular stimulation is analyzed in detail for spherical cells. Three main mechanisms were identified that prevent the generation of action potentials at high stimulation strengths: 1) strong potassium currents, 2) inactivating sodium ion channels, and 3) sodium current reversal. Ion channel kinetics in retinal ganglion cells, pyramidal cells, and the original Hodgkin-Huxley model were investigated under the influence of an extracellular stimulus.
Stratifin Inhibits SCFFBW7 Formation and Blocks Ubiquitination of Oncoproteins during the Course of Lung Adenocarcinogenesis
Authors: Shiba-Ishii Aya , Hong Jeongmin , Hirokawa Takatsugu , Kim Yunjung , Nakagawa Tomoki , Sakashita Shingo , Sakamoto Noriaki , Kozuma Yukinori , Sato Yukio , Noguchi Masayuki 
Published: February 2019

Abstract

Purpose:
Aberrant overexpression of SFN (stratifin) plays an oncogenic role in lung adenocarcinoma. We have shown previously that SKP1, an adapter component of E3 ubiquitin ligase forming an SCF complex, is a unique SFN-binding protein in lung adenocarcinoma cells.

Experimental Design:
In silico simulation and in vitro mutagenesis analysis were performed to identify the SFN-binding domain on SKP1. We examined expression, localization, and stability of SKP1 after knockdown of SFN using lung adenocarcinoma cells including A549. In silico library screening and experimental validation were used for drug screening. Daily oral administration of each candidate drugs to A549-injected tumor-bearing mice was performed to evaluate their in vivo antitumor efficacy.

Results:
Suppression of SFN upregulated the stability of SKP1 and accelerated its cytoplasm-to-nucleus translocation. Consistently, IHC analysis revealed that cytoplasmic expression of SKP1 was significantly associated with SFN positivity, tumor malignancy, and poorer patient outcome. After SFN suppression, ubiquitination of oncoproteins, including p-cyclin E1, p-c-Myc, p-c-Jun, and cleaved Notch 1, which are target proteins of SCFFBW7, was strongly induced. These results indicate that SFN–SKP1 binding results in SCFFBW7 dysfunction and allows several oncoproteins to evade ubiquitination and subsequent degradation. Because inhibition of SFN-SKP1 binding was expected to have antitumor efficacy, we next searched for candidate SFN inhibitors. Aprepitant and ticagrelor were finally selected as potential SFN inhibitors that dose dependently reduced SFN-SKP1 binding and tumor progression in vivo.

Conclusions:
As overexpression of SFN is detectable in most adenocarcinoma, we believe that SFN inhibitors would be novel and promising antitumor drugs for lung adenocarcinoma.
Going through Changes: Surface IgM Levels during CLL Therapy with Ibrutinib
Authors: Burger Jan A. 
Published: February 2019

Abstract
Continuous B-cell receptor (BCR) stimulation by antigens in secondary lymphoid tissues is a key pathogenic mechanism in chronic lymphocytic leukemia (CLL). Therapy with ibrutinib mobilizes tissue CLL cells into the peripheral blood (PB), away from tissue antigen. Consequently, mobilized antigen-deprived CLL cells upregulate surface immunoglobulin M (IgM), providing robust evidence for this mechanism of pathogenesis.
See related article by Drennan et al., p. 2503
Uremic Patients with Increased Vascular Calcification Score Have Serum with High Calcific Potential: Role of Vascular Smooth Muscle Cell Osteoblastic Differentiation and Apoptosis
Authors: Ciceri Paola , Galassi Andrea , Alfieri Carlo , Messa Piergiorgio , Cozzolino Mario 
Published: February 2019

<b><i>Background/Aims:</i></b> Uremic patients experience premature vascular ageing that causes cardiovascular morbidity. In this study, we investigated the relationship between uremic serum calcific potential induced by high phosphate (Pi) and vascular calcification score (VCS). <b><i>Methods:</i></b> Vascular smooth muscle cells (VSMCs) were cultured with 3.5 mM Na<sub>3</sub>PO<sub>4</sub> (Pi) with 10% uremic serum and calcium deposition, markers of osteoblastic transformation, and apoptosis were evaluated. <b><i>Results:</i></b> Culture with uremic serum and high-Pi significantly induced calcification (0.21 ± 0.03 vs. 8.05 ± 0.6; ctr vs. Pi; OD/mg protein; <i>p</i> &#x3c; 0.01). We next stratified patients with respect of the degree of VCS in 2 groups: absence of vascular calcification (VC) “no VC group” and presence of VC “VC group”. We found that there was a significant correlation between VCS and uremic serum calcific potential induced by high Pi in vitro (<i>p</i> &#x3c; 0.01). Interestingly, uremic sera of the “VC group” were more effective than sera from the “no VC group”, in downregulating α-actin and SM22α, after treatment with high-Pi (41.3 ± 4.7 vs. 23.3 ± 2.9 and 25.6 ± 6.8 vs. 8.14 ± 2.3; VC vs. no VC group, α-actin and SM22α respectively; Δ intensity area; <i>p</i> &#x3c; 0.01). Similarly, sera from “VC group” were more effective than sera from “no VC group” in adjuvanting the high-Pi effect of increasing osteoblastic markers, such as bone morphogenic protein 2 (BMP2), osteocalcin (OC), and runt-related transcription factor 2 (RUNX2; 39.1 ± 11.3 vs. 5.0 ± 2.6 BMP2; 12.2 ± 4.2 vs. 1.7 ± 0.3 OC; 2.9 ± 0.4 vs. 1.2 ± 0.2 RUNX2; VC vs. no VC group respectively; <i>p</i> &#x3c; 0.05). We found a similar pattern with significantly higher apoptosis and necrosis induction by sera from the “VC group” compared to the “no VC group” (2.05 ± 0.33 vs. 1.29 ± 0.13 and 54.1 ± 19.5 vs. 27.4 ± 10.6; Pi; VC group vs. no VC group; enrichment factor of apoptotic or necrotic fragments, respectively; <i>p</i> &#x3c; 0.05). <b><i>Conclusions:</i></b> We conclude that VCS of end-stage renal disease patients significantly correlates with serum-calcific potential induced by high Pi. In addition, uremic patients with higher VCS have sera with a higher potential to induce VSMC osteoblastic trans-differentiation, apoptosis, and necrosis.