bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical Modeling and Experimental Validation of Advanced Rotary Shouldered Threaded Connections
Authors: Song Fei , Du Michael H. , Li Ke 
Published: February 2019

Abstract
To mitigate the risk of twistoff during high dogleg-severity (DLS) drilling and to reduce cost of service delivery induced by frequent recuts, an advanced rotary shouldered threaded connection design with significantly enhanced fatigue life over existing API connections has recently been developed and released for field operation. Modeling and simulation techniques had been extensively used to drive the design and qualification processes. In this paper, an overview of the numerical modeling methodology and its experimental validation is presented with an emphasis on the key functional requirements of the design.
The newly developed connection design involves an optimized thread form and an advanced manufacturing process. Finite element analysis (FEA) was heavily used to optimize the design prior to physical prototyping and testing. High-fidelity modeling methods were developed, and comprehensive numerical analyses were performed to digitally evaluate the performance of the new design, including fatigue resistance, galling resistance, combined load capacity, sealability, and so on. The FEA models had very well predicted the performance of the new design, which was later validated through full-scale experimental tests. Several qualification tests, such as torsional yield limit test and tensile capacity test, were carried out completely digitally. As a result of the extensive modeling and simulation work conducted, the connection design met all requirements in one iteration.
The work presented in this paper represents a successful example of model-driven product development, which significantly reduces development time and cost. It is the first time that a high-fidelity modeling methodology, in conjunction with full-scale experimental validation, is introduced for advanced rotary shouldered threaded connections in the oil and gas industry.
Binafuxi Granules in the treatment of common cold with heat syndrome based on traditional Uighur medicine: study protocol for a multicenter randomized controlled trial
Authors: Min Jie , She Bin , Zhang Xin , Mao Bing , Chen Yan 
Published: February 2019

Abstract
Background

Common cold is a highly prevalent illness with significant impact on society and health care. Common cold with heat syndrome (CCHS) is one of most common type based on traditional Uighur medicine (TUM) syndrome differentiation, which is widely used in Central Asia. The study is designed to explore the efficacy, safety and optimal therapeutic dosage of Binafuxi Granules in treating CCHS.

Methods

This is a multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. A total of 240 patients will be recruited from 5 centers across China and randomly assigned to the high-dose group, low-dose group or placebo control group in a 1:1:1 ratio. All subjects will receive test drugs twice daily for 3 days. The primary outcome is the time to fever relief. Secondary outcomes include the time to fever clearance, duration of primary symptoms and each symptom, change in TUM symptom score.

Discussion

This is the first placebo-controlled randomized clinical trial for a Uighur medicine in treating common cold. It will provide robust evidence on the efficacy and safety of Binafuxi Granules in the treatment of CCHS.

Trial registration

The registration number is ChiCTR-IIR-17013379, which was assigned by the Chinese Clinical Trial Registry on 14 November 2017.
A case report of spontaneously healed isolated posterior inferior cerebellar artery dissection with headache alone
Authors: Kishi Yo 
Published: February 2019

Abstract
Background
Isolated posterior inferior cerebellar artery dissections can cause subarachnoid hemorrhages or infarctions. Surgical treatments for hemorrhagic stroke cases and medical treatments using antithrombotic agents for ischemic stroke cases have been done, whereas there are very few reports on non-stroke posterior inferior cerebellar artery dissections and the treatment strategy for non-stroke cases has not been established. This is the first detailed report on spontaneously healed isolated posterior inferior cerebellar artery dissection with headache alone.
Case presentation
48 years old healthy male felt severe right-side throbbing headache and came to OIKE Clinic on the fourth day after the onset. MRI studies revealed his right posterior inferior cerebellar artery dissection and showed no infarctions or hemorrhages. He was observed carefully under continuous monitoring of blood pressure and hydrated sufficiently, given analgesic anti-inflammatory agents. Two weeks later, the dissected vessel’s diameter grew up to the maximal size, though the patient’s headache was rapidly improved around that day. Surgical treatments for prevention of subarachnoid hemorrhage were considered but careful conservative therapy continued in accordance with the patient’s strong desire. Gradually the dissection finding had been improving. Four months later, MRI study showed his right posterior inferior cerebellar artery was seen almost normal in size and shape.
Conclusions
With the progress of high resolution MRI techniques, iPICAD will be detected more frequently. Further collection and assessment of iPICAD cases will lead to determine the optimal therapeutic strategy for iPICAD with headache alone.
Potent Cytotoxic Natural Flavonoids: The Limits of Perspective
Authors: Taleghani Akram , Tayarani-Najaran Zahra 
Published: February 2019

Background:Besides the numerous biologic and pharmacologic functions in the human body that act as potent antioxidants, flavonoids (flavones, flavanones, flavonols, flavanols and isoflavones) are noted as cancer preventive or therapeutic agents.Methods:This review summarizes the published data using PubMed, Science Direct, and Scopus.Results:In this context, recognition and introduction of the most active cytotoxic flavonoids as promising agents for cancer therapy gives insight for further evaluations. However, there are some critical points that may affect the entering of flavonoids as active cytotoxic phytochemicals in the clinical phase. Issues such as the abundance of active species in nature, the methods of extraction and purification, solubility, pharmacokinetic profile, presence of the chiral moieties, method of synthesis, and structure modification may limit the entry of a selected compound for use in humans. Although plenty of basic evidence exists for cytotoxic/antitumor activity of the versatility of flavonoids for entry into clinical trials, the above-mentioned concerns must be considered.Conclusion:This review is an effort to introduce cytotoxic natural flavonoids (IC50< 10 µM) that may have the potential to be used against various tumor cells. Also, active constituents, molecular mechanisms, and related clinical trials have been discussed as well as the limitations and challenges of using flavonoids in clinic.
Future Anti-aldosterone Agents
Authors: Dimitriadis Kyriakos , Tsioufis Constantinos , Iliakis Panayotis , Kasiakogias Alexandros , Andrikou Ioannis , Leontsinis Ioannis , Konstantinidis Dimitrios , Tousoulis Dimitrios 
Published: February 2019

Background:
Targeting the renin-angiotensin-aldosterone axis is one of the most important therapeutic
pathways for blood pressure control, renal and cardiovascular protection.

Objective:
In this review, the new nonsteroidal mineralcorticoid receptor antagonists will be presented with a
special focus on finerenone and its randomized controlled trials along with an introduction to the clinically promising
aldosterone synthase inhibitors.

Method:
We conducted an in-detail review of the literature in order to draft a narrative review on the field.

Results:
Development of new anti-aldosterone agents focusing on the diverse components of aldosterone production
and action is now taking place. Nonsteroidal mineralοcorticoid receptor antagonists are safe and effective
therapeutic solutions with finerenone being the most well-studied agent with promising clinical data extending its
efficacy in diabetes mellitus, chronic kidney disease and heart failure. Aldosterone synthase inhibitors impact the
hormonal balance but there are still limitations regarding the duration of action and adverse effect of the glycolcorticoid
axis.

Conclusion:
Novel third-generation, nonsteroidal mineralocorticoid receptor antagonists seem to offer great
advantages, which may lead to a wider use of mineralocorticoid receptor antagonists. Future randomized controlled
trials are needed to evaluate significant perspectives.
Anti-inflammatory Effect of Woodfordia fructicosa Leaves Ethanolic Extract on Adjuvant and Carragenan Treated Rats
Authors: Raj Hem , Gupta Avneet , Upmanyu Neeraj 
Published: February 2019

Background:
Woodfordia fructicosa is used traditionally for the treatment of inflammation
associated with arthritis.

Methods:
In the present study, the anti-inflammatory activity of W. fructicosa (WFE)
leaves ethanolic extract was assessed in Sprague Dawley rats by giving 200 mg/kg dose
orally. Inflammation was studied by using carrageenan induced paw edema, Freund’s adjuvant
(FA) and monosodium iodo acetate (MIA) induced arthritis as animal models. Serum
tumor necrosis factor-alpha (TNF-α) was estimated in blood sample of animals treated
with FA. The one way ANOVA followed by Bonferroni’s test was used for statistical
analysis.

Results:
WFE significantly decreased (P<0.05, P<0.001) paw thickness in carrageenan induced
paw edema and FA induced arthritis. The significant decrease in knee diameter
(P<0.001) in MIA induced arthritis as well as inhibitory effect (P<0.001) on elevated TNF-
α was observed.

Conclusion:
These results showed that the WFEexerted an inhibitory effect on TNF-α and
carrageenan paw edema which may justify its traditional use in inflammatory conditions.
Thus, the study shows that leaves of W. fruticose afford anti-inflammatory activity by
preventing the inflammation in different animal models.
A Comparison of Different Methods of MWCNTs Metalation in a Single Step Using Three Different Silver-containing Compounds
Authors: García Beatriz O. , Kharissova Oxana V. , Dias Rasika , Aguirre-Tostado Francisco S. , Leyva César , González Lucy T. , Kharisov Boris I. 
Published: February 2019

Background:
Synthesis and applications of Ag-coated carbon nanotubes are currently under
intensive research, resulting in a series of recent patents. Silver nanoparticles are normally obtained
from silver nitrate. However, there are also other silver-containing compounds that can facilitate the
production of silver nanoparticles, such as silver(I) acetate and silver(II) oxide. Being combined with
carbon nanotubes, silver nanoparticles can transfer to them some of their useful properties, such as
conductivity and antibacterial properties, and contribute to improving their dispersion in solvents.

Objective:
To apply three different silver-containing precursors of Ag nanoparticles for the decoration
of carbon nanotubes and study the morphology of formed composites by several methods.

Method:
Three different silver compounds were used as Ag source to carry out the functionalization
and decoration of carbon nanotubes under ultrasonic treatment of the reaction system, containing,
commercial carbon nanotubes, organic peroxides as oxidants or hydrazine as a reductant, and a surfactant.
Resulting samples were analyzed by XRD and XPS spectroscopy, as well as TEM and SEM microscopy
to study the morphology of formed nanocomposites.

Results:
Silver nanoparticles can be produced without the presence of a reducing agent. Applying hydrazine,
as a reducing agent, it is possible to obtain functionalized carbon nanotubes doped with silver nanoparticles,
in which their sizes are smaller (1-5 nm) compared to those obtained without using hydrazine.

Conclusion:
Silver nanoparticles having a size range between 2-60 nm can be produced without the
presence of a reducing agent. The use of a reducing agent, such as hydrazine, affects the size of silver
nanoparticles.
Effects of a Standardized Care Protocol for Patients with Degenerative Spine Disease
Authors: Lim Hwa-Jung , Kim Bo-Yeoul 
Published: February 2019

Background:Many patients facing spinal surgery experience fear and anxiety about surgery, anesthesia, risk of postoperative pain or complications, or even death. Spinal surgery patients often experience mobility disorders due to lasting postoperative pain and require aids such as spinal braces, which can induce depression. Alleviating patients’ anxiety and depression during the perioperative period by utilizing consistent and standardized information is required for high-quality care.Objective:We developed and assessed a standardized care protocol for degenerative spinal surgery patients.Methods:The protocol was developed through focus group interviews with spinal surgery patients and the recommendations of an expert panel. Then, a quasi-experimental design was employed to comparatively study patients undergoing spinal surgery. Ninety-eight Patients were assigned to either a treatment group (n= 49) or a control group (n= 49). The treatment group received an intervention based on the newly developed standardized care protocol, while the control group received traditional care. After treatment, participants’ anxiety, depression, uncertainty, and care satisfaction were compared between groups.Results:Patients who had received the care protocol-based intervention showed lower anxiety, depression, and uncertainty, and higher satisfaction than did those who received traditional care.Conclusion:The developed care protocol may be useful for reducing anxiety and depression and for improving the healthcare provided to spinal surgery patients, as it involves the proactive dissemination of accurate information throughout the hospitalization process. The protocol also positively affected patients’ uncertainty and satisfaction with their medical care.
CNFET Based Low Power Full Adder Circuit for VLSI Applications
Authors: Hussain Inamul , Chaudhury Saurabh 
Published: February 2019

Background:
The Adder is one of the most prominent building blocks in VLSI circuits
and systems. Performance of such systems depends mostly on the performance of the adder cell.
The scaling down of devices has been the driving force in technological advances. However, in
CMOS technology performance of adder cell decreases as technology node scaled down to deep
micron regime.

Objective:
With the growth of research, new device model has been proposed based on carbon
nano tube field effect transistor (CNFET). Therefore, there is a need of full adder cell, which performs
sufficiently well in CNFET as well as different CMOS technology nodes.

Method:
A new low power full adder cell has been proposed with a hybrid XOR/XNOR module
by using CNFET, which is also compatible for the CMOS technology nodes. The performance of
the adder cell is validated with HSPICE simulation in terms of power, delay and power delay
product. It is observed that the proposed adder cell performs better than the CMOS, CPL, TGA,
10 T, 14 T, 24 T, HSPC and Hybrid_FA adder cells. The CNFET full adder is designed in 32 nm
CNFET model and to appraise its compatibility with Bulk-Si CMOS technology, 90 nm and 32 nm
CMOS technology node is used.

Conclusion:
The proposed adder is very much suitable for both CMOS and CNFET technology
based circuits and systems. To validate the result, simulation has been carried out with Synopsis
tool. This full adder will definitely dominate other full adder cells at various technology nodes for
VLSI applications.
A Comparative Investigation of Complex Conjugate Eigenvalues of Generalized Morse and Classical Lennard-Jones Potential for Metal Atoms
Authors: Surulere Samuel A. , Shatalov Michael Y. , Mkolesia Andrew C.P.G. , Adeniji Adejimi A. 
Published: February 2019

Background:The knowledge of parameter estimation for interatomic potentials is useful in the computation of the vibrational structure of van der Waals molecules.Methods:On the estimation of the Generalized Morse and Classical Lennard-Jones potential energy functions, complex conjugates eigenvalues may be obtained. Different approaches can be used to solve this resulting problem. A method that uses the objective least squares function method to estimate parameters of the interatomic potentials is employed.Results:Numerical simulation of the systems using metal atoms yields complex conjugates eigenvalues at some initial point.Conclusion:Other approaches of solving the complex conjugates eigenvalues problem are discussed comprehensively.
Polimorfismos de los genes Calpaína y Calpastatina en dos poblaciones de Ovinos de Pelo Colombiano
Authors: Montes Vergara Donicer , Lenis Valencia Claudia , Hernandez Herrera Darwin 
Published: February 2019

Objetivo. El propósito del presente estudio fue caracterizar el polimorfismo genético tipo SNPs en los genes calpaína (CAPN) y calpastatina (CAST) en el ovino de pelo criollo colombiano (OPC). Materiales y métodos. 300 individuos pertenecientes a dos subpoblaciones de OPC de los departamentos de Sucre (SC) y Valle del Cauca (VC) fueron genotipados por PCR–RFLP (MspI) para el locus CAST y por PCR–SSCP para el locus CAPN. Se calcularon las frecuencias genotípicas, alélicas, la heterocigocidad observada (Ho) y esperada (He), el índice de fijación (F), los desvíos del equilibrio de Hardy-Weinberg (EHW) y un análisis de varianza molecular para estimar los valores de FST, FIS y FIT. Resultados. En el locus CAST, el genotipo MM fue el más frecuente (83.9±1.1%), seguido por los otros genotipos (MN: 15.5±1.1; NN:6.0±0.0%) y la frecuencia alélica de M (91.7±0.4%) superó la del N (8.3±0.4%). Para el locus CAPN el genotipo heterocigoto (48.2±0.7%) fue el más frecuente; los otros genotipos presentaron frecuencias de TT:44.7±1.9 y CC:7.0±1.4%. El alelo T alcanzó una frecuencia de 68.8±1.5% (C:31.3±1.5%). Similares frecuencias alélicas y genotípicas se encontraron en las subpoblaciones. La He fue menor que la Ho en ambos loci, con valores negativos de F y desvios de EHW solo en CAPN. Toda la variación encontrada fue debida a diferencias dentro de los individuos, con valores no significativos (p>0.05) de FST, FIS y FIT (0.002, -0.093 y -0.095, respectivamente). Conclusiones. Los loci estudiados tiene alta variabilidad, estos resultados pueden ser utilizados para futuros planes de selección asistida por genes para aumentar la productividad del OPC.
Pengembangan Video Pembelajaran Pembuatan Sabun Herbal Minyak Atsiri Kayu Manis
Authors: TE Yuni Tasmalina , Atmanto Dwi , Maulida Ernita 
Published: February 2019

Penelitian ini bertujuan untuk: 1) menghasilkan video pembelajaran tentang proses pembuatan sabun herbal dengan penambahan minyak atsiri kayu manis yang tepat untuk digunakan sebagai media pembelajaran; dan 2) menguji kelayakan video pembelajaran yang dihasilkan guna meningkatkan hasil belajar peserta didik pada mata kuliah Kimia Kosmetika. Media pembelajaran yang dikembangkan pada penelitian ini adalah video pembuatan sabun herbal dengan tambahan minyak atsiri kayu manis dimulai dari proses penyulingan kulit kayu manis hingga menjadi produk sabun herbal. Metode penelitian yang digunakan adalah metode penelitian dan pengembangan (R&D) dengan model pengembangan gabungan antara model Borg & Gall, Model Dick & Carey dan Model Hannafin & Peck. Prosedur pengembangan media meliputi tahap desain, pengembangan dan evaluasi. Teknik analisis data untuk uji coba produk menggunakan statistik deskriptif. Hasil penelitian sebagai berikut. (a) media yang dikembangkan dinilai layak digunakan dalam pembelajaran ditinjau dari aspek media dan materi. Kelayakan tersebut dapat dilihat dari skor penilaian ahli media 3,88 dan skor ahli materi 4,0 dengan kategori sangat baik. (b) Multimedia pembelajaran tata rias wajah korektif dinilai efektif karena dapat meningkatkan pengetahuan dan keterampilan. Hal ini dibuktikan melalui hasil nilai pre-test aspek kognitif dengan rata-rata nilai 51,22 dan nilai post-test dengan rata-rata nilai 75,33. Hasil nilai ranah psikomotorik dengan rata-rata nilai 81,98.
Archie Bunker ja konservatismi sarjassa Perhe on Pahin
Authors: Winberg Oscar 
Published: February 2019

Archie Bunker ja konservatismi sarjassa Perhe on pahinSitcom-sarja Perhe on pahin (All in the Family) sai vuonna 1971 ensiesityksensä CBS:llä Yhdysvalloissa. Sarjasta tuli pian Amerikan katsotuin, ja se myös säilytti kyseisen asemansa viiden vuoden ajan. Sarjan päähenkilö Archie Bunkerista tuli lähes välittömästi poliittinen ikoni, ja hän alkoi representoida konservatiivisuutta 1970-luvun alun kontekstissa.Artikkeli tarkastelee 1960-luvun lopun televisiopolitiikkaa – kontekstia, johon Perhe on pahin on väistämättä sidoksissa – ja osoittaa, että Archien poliittiset käsitykset ovat liian ambivalentteja tullakseen ymmärretyiksi pelkästään konservatiivisina. Vaikka Archie on erityisesti sosiaalisiin asioihin liittyen konservatiivi, hän ei edusta konservatiivista ideologiaa. Laissez-fairelaisen talouspoliittisen ajattelun sijaan Bunker tukee niin työväenliittoja kuin hallituksen tukijärjestelmiäkin. Richard Nixonin tarkoitus luoda ”suuri konservatiivinen enemmistö” jättämällä taloudelliset periaatteet taka-alalle selittää, miksi Archie Bunker on tullut edustamaan konservatiivisuutta. Archie Bunker And Conservatism in the Series All in the FamilyIn 1971, the sitcom All in the Family premiered on CBS in the United States. The show soon became the most watched show in America, and held that position for an unprecedented five consecutive years. Archie Bunker, the main character of the show, almost instantly became a political icon and a representation of conservatism in the early 1970s.This article explores the politics of the late 1960s television, from which All in the Family emerged, and then shows how Archie’s politics on the show are too ambivalent to be described as conservative. While conservative on some issues, especially social issues, he does not align with conservative ideology. Instead of a laissez-faire attitude towards economic policy, Bunker supports both labor unions and government welfare in the form of Social Security. The efforts of Richard Nixon to deemphasize economic policy in creating a conservative majority, instead, explain the understanding of Archie as the embodiment of a new conservative majority.