bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transjugular Liver Biopsy: Safe Even in Patients With Severe Coagulopathies and Multiple Biopsies
Authors: Sue Megan J. , Lee Edward W. , Saab Sammy , McWilliams Justin P. , Durazo Francisco , El-Kabany Mohamed , Kaldas Fady , Busuttil Ronald W. , Kee Stephen T. 
Published: June 2019

OBJECTIVES:
To investigate the safety profile and diagnostic efficacy of transjugular liver biopsy (TJLB), with a focus on patients with severe coagulopathies and with multiple biopsies.

METHODS:
Clinical, laboratory, and demographic information was collected on 1,321 TJLBs in 932 patients (mean age 43.5 ± 23.2 years) performed between January 2009 and May 2017 to determine the diagnostic success rate and incidence of both major and minor complications in the 3-day and 30-day period post-biopsies. These outcomes were also analyzed for severely coagulopathic patients and a subgroup of patients who underwent multiple biopsies.

RESULTS:
The overall success rate (diagnostic yield) of the TJLB procedure was 97.7% (1,291/1,321). Overall, the major and minor complication rates were 1.0% (13/1,321) and 9.5% (126/1,321), respectively. In patients with multiple biopsies, the overall complication rate was similar to the entire study cohort, which was 10.4% (57/550). Patients were also stratified according to the platelet counts of 0–50, 51–100, 101–200, 201–300 and >300 × 103 platelets/μL. The overall complication rates were 8.0% (10/124), 11.6% (36/310), 9.9% (54/547), 11.9% (28/235), and 14.3% (11/77), respectively, and these were not statistically significant from each other. Patients were also stratified by international normalized ratio into 0–1, 1.1–2, 2.1–3, and >3. The overall complication rates of these patients were 8.0% (19/237), 11.8% (113/954), 16.3% (7/43), and 0% (0/9), respectively, and were not statistically significant from each other.

DISCUSSION:
TJLB is a highly efficacious, well-tolerated and safe procedure. It can be safely performed multiple times in the same patient or in critically ill, severely coagulopathic patients with no significant increase in the rate of complication while maintaining an extremely favorable diagnostic yield.
Acerca del sentido, los saberes y la praxis de la enseñanza de la Historia en las aulas de Córdoba
Authors: Toibero Desireé , Chauerba Laura 
Published: June 2019

En una indagación previa nos propusimos indagar sobre las representaciones acerca de los sentidos y saberes necesarios para la enseñanza de la Historia de seis profesores de historia de tres generaciones diferentes y con experiencia de trabajo en más de una institución en la ciudad de Córdoba, Argentina. En el marco de un nuevo proyecto de investigación nos proponemos profundizar en la comprensión del vínculo entre esas representaciones y la praxis, a partir de análisis de propuestas de enseñanza y del registro etnográfico de una clase de inicio y otra de desarrollo de la propuesta de enseñanza de los docentes. En definitiva, nos proponemos interpretar para este universo seleccionado, el vínculo entre los decires docentes, las propuestas docentes (lógicas pedagógico-didácticas) y la praxis (interacciones y producción del conocimiento). Con esta orientación, sumamos las categorías de propuesta metodológica y configuraciones didácticas.
Stanowisko Parlamentu Europejskiego wobec pomocy humanitarnej
Authors: Kaczmarek Filip 
Published: June 2019

Unia Europejska wraz z państwami członkowskim tej organizacji jest największym dawcą pomocy humanitarnej na świecie. Parlament Europejski jest jedną z kluczowych instytucji UE i jedyną spośród nich, wyłanianą w wyniku wyborów bezpośrednich. Celem tekstu jest zbadanie stanowiska Parlamentu wobec pomocy humanitarnej, począwszy od przyjęcia Konsensusu europejskiego w sprawie pomocy humanitarnej w 2007 r. do końca czerwca 2018 r. Metodą badawczą jest analiza różnych form działalności Parlamentu w badanym zakresie. Jedną z konkluzji jest zdefiniowanie dylematu Parlamentu, polegającego na próbie pogodzenia zasad pomocy humanitarnej i partykularnych interesów państw członkowskich UE.
Promotion of regional and traditional products
Authors: Oleksiuk Inga , Werenowska Agnieszka 
Published: June 2019

Podstawowym celem studiów opisanych w artykule była analiza specyfiki procesów promocyjnych produktów regionalnych i tradycyjnych z wykorzystaniem oznaczeń regulowanych przez prawo europejskie: Gwarantowana Tradycyjna Specjalność (GTS), Chroniona Nazwa Pochodzenia (ChNP), oraz Chronione Oznaczenie Geograficzne (ChOG). Dokonano krytycznego przeglądu narzędzi promocji produktów tradycyjnych i regionalnych odnosząc się do roli ochrony prawnej oznaczeń wyrobów w UE. Zwrócono uwagę, że na kształt systemu promocyjnego i informacyjnego mają wpływ uwarunkowania społeczno-kulturowe, które oddziałują na rozpoznawalność i renomę produktów, co znalazło potwierdzenie w wynikach przeprowadzonych badań sondażowych. Na uwagę zasługuje istnienie korelacji jakości z tradycją, czego wyrazem były między innymi deklaracje dotyczące motywu wyboru tych produktów: poczucie dumy i kontynuowanie tradycji wybrało 45% badanych. Najbardziej rozpoznawalnym europejskim oznaczeniem był symbol Gwarantowanej Tradycyjnej Specjalności (38%).
Lewy-Stampacchia’s inequality for a pseudomonotone parabolic problem
Authors: Guibé Olivier , Mokrane A. , Tahraoui Y. , Vallet G. 
Published: June 2019

Abstract
The main aim of this paper is to extend to the case of a pseudomonotone operator Lewy-Stampacchia’s inequality proposed by F. Donati [7] in the framework of monotone operators. For that, an ad hoc type of perturbation of the operator is proposed.
Correlations between serum and CSF pNfH levels in ALS, FTD and controls: a comparison of three analytical approaches
Authors: Wilke Carlo , Pujol-Calderón Fani , Barro Christian , Stransky Elke , Blennow Kaj , Michalak Zuzanna , Deuschle Christian , Jeromin Andreas , Zetterberg Henrik , Schüle Rebecca , Höglund Kina , Kuhle Jens , Synofzik Matthis 
Published: June 2019

Abstract

Background
Phosphorylated neurofilament heavy (pNfH), a neuronal cytoskeleton protein, might provide a promising blood biomarker of neuronal damage in neurodegenerative diseases (NDDs). The best analytical approaches to measure pNfH levels and whether serum levels correlate with cerebrospinal fluid (CSF) levels in NDDs remain to be determined.

Methods
We here compared analytical sensitivity and reliability of three novel analytical approaches (homebrew Simoa, commercial Simoa and ELISA) for quantifying pNfH in both CSF and serum in samples of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and control subjects.

Results
While all three assays showed highly correlated CSF measurements, Simoa assays also yielded high between-assay correlations for serum measurements (ϱ = 0.95). Serum levels also correlated strongly with CSF levels for Simoa-based measurements (both ϱ = 0.62). All three assays allowed distinguishing ALS from controls by increased CSF pNfH levels, and Simoa assays also by increased serum pNfH levels. pNfH levels were also increased in FTD.

Conclusions
pNfH concentrations in CSF and, if measured by Simoa assays, in blood might provide a sensitive and reliable biomarker of neuronal damage, with good between-assay correlations. Serum pNfH levels measured by Simoa assays closely reflect CSF levels, rendering serum pNfH an easily accessible blood biomarker of neuronal damage in NDDs.
The Transformation of the Christian Right’s Moral Politics
Authors: Lewis Andrew R. 
Published: June 2019

AbstractFor at least the past four decades, the Christian Right’s political advocacy has epitomized morality politics in the US. In recent years, however, the Christian Right has transformed how it approaches various moral and cultural issues, appealing to the language and process of political rights. This reframing of cultural concerns has coincided with the declining cultural status of conservative Christianity. This article analyzes three issue areas—abortion, free speech, and religious freedom—documenting how conservative Christianity has altered its approach to public politics, coming to embrace individual rights language and arguments over and above common morality. The article also analyzes the whether this growing rights talk has contributed to extending support to the rights of others, finding mixed results. As conservative Christians have embraced the rights commitment for themselves, there has been a corresponding growth of political tolerance for others. At the same time, there remain prominent challenges to supporting pluralistic politics. While questions about the commitment to pluralism remain, the evolution of the Christian Right’s cultural style of politics has important implications, as the last vestige of communitarian politics routinely engages politics using the language of liberalism. Moral politics are now routinely rights politics.
Morality Politics and New Research on Transgender Politics and Public Policy
Authors: Haider-Markel Donald , Taylor Jami , Flores Andrew , Lewis Daniel , Miller Patrick , Tadlock Barry 
Published: June 2019

AbstractRecent political debate over transgender military service and gendered bathroom use highlights a dramatic increase in salience over transgender issues in the US. In this essay, we examine a potential new front in the culture wars by reviewing recent empirical research in social science on the politics of transgender rights in the context of morality politics. Research on morality politics has often focused on LGBT rights, with an emphasis on gay and lesbian rights and little attention to transgender issues. We highlight the progress of research on transgender issues in the US, focusing on the study of attitudes about transgender people and rights, transgender rights in states and localities, and broader findings affecting transgender populations. Although there is ample research still needed, the current state of empirical social science on transgender issues has made great advancements in the past decade and shows that morality continues to shape LGBT politics and policy.
Generational Change? The Effects of Family, Age, and Time on Moral Foundations
Authors: Friesen Amanda 
Published: June 2019

AbstractOne way to uncover the persistent role of religion across generations is to look past traditional understandings of religious belief and denominational belonging and examine the presence of bedrock principles that could influence political beliefs in families. The Moral Foundations framework was developed for this purpose – to describe human behavior and attitudes in the moral realm without relying upon country, culture, or time specific labels. In an original and rare three-generation dataset, college students, their parents, and their grandparents were asked about political attitudes and preferences for the Moral Foundations of Harm/Care, Fairness/Reciprocity, Ingroup/Loyalty, Authority/Respect, and Purity/Sanctity. The Foundations are not equally shared across generations as preferences for each Foundation increase with the age of the cohorts in this sample, with especially large differences on Authority and Purity. A follow-up survey reveals that Moral Foundations may not be stable across even short periods of time. These findings suggest that the political appeals that may work on older Americans may be less effective on the younger generations. If individuals indeed make moral decisions based on these types of bedrock principles, understanding which of these principles or Foundations drive particular age groups can help us better understand shifts in public opinion.
Exploring the role of humor in the management of existential anxiety
Authors: Morgan Jessica , Smith Rebecca , Singh Amrik 
Published: June 2019

Abstract
The current study addressed a topic that has both theoretical and applied importance, by examining the potential existential anxiety-buffering function of humor. Participants (N = 556; 55% female; M age = 37 years) completed a measure of trait coping humor before being randomly assigned to a mortality salience condition and a humor induction condition and then completing a measure of death-thought accessibility. ANOVA revealed main effects of trait coping humor, mortality salience and humor induction on death-thought accessibility in the expected directions. Coping humor interacted with mortality salience (F(1,439) = 14.47, p < 0.01) showing that low coping humor participants were more affected by the mortality salience manipulation. Coping humor also interacted with humor induction (F(1,439) = 8.94, p < 0.01) showing that low coping humor participants were more affected by the humor induction. Findings suggests that whilst trait coping humor appears to buffer the effects of mortality salience, those low in trait coping humor may benefit the most from interventions aimed at reducing existential anxiety via humor. The apparent beneficial effect of humor induction for individuals low in coping humor holds a promise of advancing our understanding of existential threat and, ultimately, providing a basis for interventions to improve mental health.
Comic styles and their relation to the sense of humor, humor appreciation, acceptability of prejudice, humorous self-image and happiness
Authors: Mendiburo-Seguel Andrés , Heintz Sonja 
Published: June 2019

AbstractThe present study investigates the relationships of eight comic styles (fun, benevolent humor, nonsense, wit, irony, satire, sarcasm, and cynicism) with acceptability of prejudice (laughing at different groups and topics), humorous self-image (funniness and frequency of laughter), humor appreciation (funniness and aversiveness of cartoons with different structures and contents), and happiness. A representative Chilean adult sample (N=857, 60.8% women; age M=40.50, SD=17.28) was recruited in face-to-face interviews and online surveys. They completed self-reports of all variables as well as a humor appreciation test. Most of the comic styles related to finding the cartoons funnier. Furthermore, the darker styles were more strongly related to laughing at a variety of topics and groups. Also, happiness was positively related to fun and benevolent humor and negatively to cynicism. This study provides evidence of the criterion validity of the Comic Style Markers in Latin-American cultures and highlights differences between lighter and darker styles.
Review: Seafood Allergy and Potential Application of High Hydrostatic Pressure to Reduce Seafood Allergenicity
Authors: Zhang Yifeng , Ren Yuanyuan , Bi Yuge , Wang Qi , Cheng Ka-Wing , Chen Feng 
Published: June 2019

Abstract
High hydrostatic pressure (HHP), a novel non-thermal processing technology, can inactivate microorganisms in food with ultra-high pressure over 100 MPa. In recent years, it has shown unique potential in alleviating seafood allergenicity. Seafood, as a primary high-quality protein source, is one of popular food products in many human populations, while seafood allergy remains an obstacle to the consumption of seafood and calls for processing raw materials to reduce their allergenicity. Heating and fermentation as conventional methods, along with HHP as a rising novel technology, have been applied in seafood processing, such as shrimp and squid. This review provides a brief introduction of current key publications and limitations of researches on seafood allergy. In addition, characteristics and principles, processing parameters and effects of HHP treatment on seafood of current researches were detailed. Our main goal was to support readers to keep abreast with knowledge on seafood allergy and provide new insights of using HHP for seafood processing to achieve lower allergenicity.
A note on Frobenius–Wielandt groups
Authors: Kaplan Gil 
Published: June 2019

Abstract
Let G be a finite group.
G is called a Frobenius–Wielandt group if there exists

H
<
G

{H<G}

such that

U
=

〈

H
∩

H
g

∣

g
∈

G
-
H

〉

{U=\langle H\cap H^{g}\mid g\in G-H\rangle}

is a proper subgroup of H.
The Wielandt theorem
[H. Wielandt,
Über die Existenz von Normalteilern in endlichen Gruppen,
Math. Nachr. 18 1958, 274–280;
Mathematische Werke Vol. 1, 769–775]
on the structure of G generalizes the celebrated Frobenius theorem.
From a permutation group point of view, considering the action of G on the coset space

G
/
H

{G/H}

, it states in particular that the subgroup

D
=

D
G

⁢

(
H
)

{D=D_{G}(H)}

generated by all derangements (fixed-point-free elements) is a proper subgroup of G.
Let

W
=

U
G

{W=U^{G}}

, the normal closure of U in G.
Then W is the subgroup generated by all elements fixing at least two points.
We present the proof of the Wielandt theorem in a new way (Theorem 1.6, Corollary 1.7, Theorem 1.8) such that the unique component whose proof is not elementary or by the Frobenius theorem is the equality

W
∩
H

=
U

{W\cap H=U}

.
This presentation shows what can be achieved by elementary arguments and how Frobenius groups are involved in one case of Frobenius–Wielandt groups.
To be more precise, Theorem 1.6 shows that there are two possible cases for a Frobenius–Wielandt group G with

H
<
G

{H<G}

:
(a)

W
=
D

{W=D}

and

G
=

H
⁢
W

{G=HW}

, or
(b)

W
<
D

{W<D}

and

H
⁢
W

<
G

{HW<G}

.
In the latter case,

G
/
W

{G/W}

is a Frobenius group with a Frobenius complement

H
⁢
W

/
W

{HW/W}

and Frobenius kernel

D
/
W

{D/W}

.
A flux-corrected RBF-FD method for convection dominated problems in domains and on manifolds
Authors: Sokolov Andriy , Davydov Oleg , Kuzmin Dmitri , Westermann Alexander , Turek Stefan 
Published: June 2019

Abstract
In this work, we present a Flux-Corrected Transport (FCT) algorithm for enforcing discrete maximum principles in Radial Basis Function (RBF) generalized Finite Difference (FD) methods for convection-dominated problems. The algorithm is constructed to guarantee mass conservation and to preserve positivity of the solution for irregular data nodes. The method can be applied both for problems defined in a domain or if equipped with level set techniques, on a stationary manifold. We demonstrate the numerical behavior of the method by performing numerical tests for the solid-body rotation benchmark in a unit square and for a transport problem along a curve implicitly prescribed by a level set function. Extension of the proposed method to higher dimensions is straightforward and easily realizable.
Diagnosis of cyclic Cushing’s disease manifests as early morning hyperglycemia in a patient with previously well-controlled type 1 diabetes
Authors: Singer-Granick Carol , Liu James K. , Bleich David , Cespedes Lissette 
Published: June 2019

Abstract

Background
Cyclic Cushing’s disease (CCD) is reported to occur in approximately 15% of patients with Cushing’s disease (CD). CCD is a rare phenomenon in children.

Case presentation
A Portuguese female with well-controlled type 1 diabetes (T1DM) on an insulin pump developed transient uncontrolled blood sugar every morning. Increased basal and bolus insulin dosing was ineffective in lowering blood sugar and she began to miss school because of nausea, vomiting, fatigue, but no ketoacidosis. Therefore, other causes of sporadic hyperglycemia were explored. Multiple 6-h urinary free cortisol (UFC) samples revealed a spike in cortisol coincident with severe hyperglycemia. Pituitary magnetic resonance imaging (MRI) revealed a 3.5 mm microadenoma and inferior petrosal sinus sampling of adrenocorticotropic hormone (ACTH) after corticotropin releasing hormone (CRH) stimulation confirmed ACTH-dependent CD. Endoscopic endonasal tumor resection led to resolution of early morning hyperglycemia and symptoms.

Discussion
Our case illustrates an atypical presentation of CCD. There are no previous case reports of a pediatric patient with T1DM and CCD. Unexplained hyperglycemia in a patient with previous well-controlled T1DM should prompt assessment of other causes. CCD can be easily be missed if timed 6-h UFC measurements are not obtained.
Natural Convection Flow of Power-Law Fluids over a Heated Horizontal Plate Surface
Authors: Dholey Shibdas 
Published: June 2019

Abstract
The current work attempts to investigate the existence of similarity solution for the natural convection boundary layer flow of a power-law fluid over a heated horizontal semi-infinite plate surface. Three types of surface temperature variation are considered, namely (i) constant surface temperature (CST), (ii) power-law variation of surface temperature (PST) and (iii) power-law variation of surface heat flux (PHF). A reduction of the governing partial differential equations is achieved by using a suitable similarity transformation. But, a careful mathematical verification confirms that the similarity solution does not exist in the CST case and for the PST case it exists only under a particular value of the wall temperature parameter r = 1/3. It also ensured the existence of similarity solution for the PHF case and this will happen only when the plate surface is held at a constant heat flux situation. A new fundamental parameter S arises from the dimensionless analysis which is reduced to the reciprocal of the usual Prandtl number Pr for Newtonian fluids. A novel result of this analysis is that the salient features of the Grashof number Gr which differentiates the thermal responses of the shear-thinning fluid (0 < n < 1) flows from the shear-thickening fluid (n > 1) flows while the Newtonian fluid (n = 1) flows remain unaffected by this parameter no matter what be the value of S.
Programmed death ligand 1 (PD-L1) expression in parathyroid tumors
Authors: Pan Boju , Wang Anqi , Pang Junyi , Zhang Yuhan , Cui Ming , Sun Jian , Liang Zhiyong 
Published: June 2019

Introduction
PD-L1 is associated with prognosis and immunotherapeutic response in patients with malignancies. In previous studies, PD-L1 expression was detected in many endocrine tumors. However, the PD-L1 expression status in parathyroid tumors is unknown.

Methods
We included 26 parathyroid carcinoma and 37 adenoma samples, as well as the corresponding patient information. PD-L1 was stained using the FDA-approved PD-L1 IHC 22C3 pharmDx and Ventana PD-L1 (SP263) assays, and staining was assessed by the estimated percentages of positive tumor cells and immune cells, respectively.

Results
We classified the PD-L1 expression in the parathyroid tumors into four groups: (0) <1%, (1) 1–4%, (2) 5–9% and (3) ≥10% positive. With the SP263 clone, 37 (carcinoma:adenoma = 18:19) samples scored 0, 13 (carcinoma:adenoma = 4:9) scored 1, 7 (carcinoma:adenoma = 1:6) scored 2 and 6 (carcinoma:adenoma = 3:3) scored 3. However, in the series of cases using the 22C3 clone, 45 (carcinoma:adenoma = 20:25) samples scored 0, 10 (carcinoma: adenoma = 3:7) scored 1, 5 (carcinoma:adenoma = 1:4) scored 2, and 3 (carcinoma:adenoma = 2:1) scored 3. Concerning tumor-infiltrating immune cells, 57 samples were negative and six were positive with SP263, and 59 were negative and four were positive with 22C3. Moreover, PD-L1 expression was negatively correlated with the Ki-67 index and mitotic rate in parathyroid tumors depending on the different clones. However, the results indicated only moderate consistency between the SP263 and 22C3 clones in parathyroid tumors.

Conclusion
We found deficient PD-L1 expression in the majority of parathyroid tumors. However, the PD-L1 expression score in parathyroid tumors depended greatly on the antibody clone used.