bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic and Social Crises, Model Change and the Responsiveness of the Legal System: Special Tax Measures and Their Regulation in Hungary
Authors: Varju Márton 
Published: November 2024

AbstractResponding to various social, economic and policy crises, Hungary has introduced and has since maintained a broad range of special taxes, imposing additional taxation on certain corporate taxpayers. These measures enabled the state to secure necessary tax revenues and make strategic adjustments to the domestic tax structure. Through the special taxes and their regulation, the Hungarian legal system was able to respond to significant changes and challenges in its social and economic environment. However, their introduction came with significant consequences for the legal system at large. As demonstrated by the case of the turnover-based progressive taxes introduced, the responsiveness of law may come at a cost of legal regulation that does not guarantee that the declared objectives and the actual effects of legal measures coincide. Such legal changes thus enable—as concealed by the words of the legislation—discriminatory, or even abusive application of the law.
Determinanten der Verkehrsmittelwahl – Forschungsstand
Authors: Graf Anne 
Published: November 2024

ZusammenfassungWährend in Abschnitt 2.3.2 die Themen multimodaler Mobilitätsforschung vorgestellt wurden, wird im Folgenden stärker auf zentrale Ergebnisse der Forschung zur Verkehrsmittelwahl eingegangen. Dazu wird auch Literatur herangezogen, die nicht direkt multimodale Mobilität zum Thema hat, aber zum Verständnis der Akzeptanz des Autos, des ÖVs oder des Fahrrads und von Mobilitätsverhalten beitragen kann.
Multimodale Mobilitätsfähigkeit – die Perspektive des Motility-Konzepts
Authors: Graf Anne 
Published: November 2024

ZusammenfassungMithilfe der Interviews werden zusätzliche Einblicke in die Organisation des Mobilitätsalltags und der Verkehrsmittelnutzung gewonnen, die mit geschlossenen Fragen in Befragungen nicht erhoben werden können. Zum besseren Verständnis multimodaler Mobilität wird die Mobilitätsfähigkeit im Sinne des Motility-Konzepts herausgearbeitet. Dazu werden die Interviews anhand der Kategorien Access, Skills und Appropriation des Motility-Konzepts analysiert.
Spatial Impact of Surface-Water Bodies on Urban Expansion Using an Autologistic Regression Model
Authors: Jia Mengyuan , Zhang Haoran 
Published: November 2024

AbstractIn order to explore the differential impacts of various types of surface water bodies on urban expansion, Taking the data in 2000, 2010, and 2020 of Tianjin as research subjects, this paper establishes the Autologistic regression models to investigate the influence of factors such as proximity to different types of surface water bodies, presence within flood storage and detention areas, and their association with aquatic ecological corridors on urban expansion. The results show that 1) flood storage and detention areas are significant constraining factors for urban expansion and the primary rivers are a more pronounced driving effect compared to other surface water bodies; 2) over the period from 2000 to 2020, the driving effect of surface water bodies on urban expansion exhibits a declining trend; 3) The delineation of urban construction land boundaries and the establishment of ecological protection zones are identified as the principal external factors shaping urban expansion. The results further explained the relationship between cities and water, and can provide a theoretical basis for the harmonious coexistence of cities and water environment.
Water Ecosystem Resilience Evaluation and Blue-Green Enhancement Strategy in Tianjin from the Perspective of Social-Ecological Resilience
Authors: Li Yangli , Zhang Rui 
Published: November 2024

AbstractThe water ecosystem, an essential component of the United Nations Sustainable Development Goals, faces challenges such as water scarcity. Resilience is one of the central objectives of sustainable development. This study aims to investigate the water ecosystem resilience in Tianjin, providing a reference for protecting and restoring the global water ecosystem. Using the DPSIR model, an evaluation system for water ecosystem resilience was constructed. The combination weighting method was used to determine the weights of evaluation indicators. A case study on the water ecosystem resilience of Tianjin reveals spatial differences in 2018, with higher resilience in the north, and lower in the south. From a spatial planning perspective, forest coverage and wetland rate are representative evaluation indicators that significantly impact Tianjin's water ecosystem resilience. The overall connectivity index analysis method was used to analyze the representative evaluation indicators, and enhancement strategies such as building forest cities and protecting and restoring wetland systems were proposed. This study provides theoretical support for improving the water ecosystem and technical guarantees for achieving sustainable development.
Investigation of Radioxenon Probability Density Functions at IMS Radionuclide Stations Using a Monte Carlo Method for Background Estimation
Authors: Kijima Yuichi , Schoemaker Robin , Tipka Anne , Liu Boxue , Kunkle Joshua , Kuśmierczyk-Michulec Jolanta , Kalinowski Martin , Prior Mark , Slinkard Megan 
Published: November 2024

Abstract
The International Monitoring System, the primary means of verification of the Comprehensive Nuclear-Test-Ban Treaty, monitors the planet for any sign of a nuclear explosion. Regarding the International Monitoring System radionuclide stations, it is known that radioxenon released from nuclear facilities such as medical isotope production facilities and nuclear power plants influences the stations. For the purposes of monitoring nuclear explosions, it is important to better understand the radioxenon background based on these nuclear facilities. The probability density functions of background activity concentration at IMS radionuclide stations are estimated using a Monte Carlo method based on emissions from known nuclear facilities and source receptor sensitivity data. This paper describes two case studies of radioxenon detections at radionuclide stations applying the developed approach. This method could be one of several prospective approaches to predict the activity concentrations of isotopes of radioxenon at radionuclide stations in Comprehensive Nuclear Test-Ban Treaty Organization’s (CTBTO’s) prototype xenon background estimation tool software. It can also be used in characterization of CTBT-relevant nuclear events for expert technical analysis.

Plain Language Summary
Civil nuclear power stations and medical isotope production facilities release radioisotopes of xenon during their normal operations. These emissions would make it harder to detect xenon produced from any nuclear weapon test that might occur. A method is described that starts with information about civil releases and produces a statistical description of the concentrations of isotopes measured at stations designed to detect nuclear tests. This information makes it possible to enhance nuclear explosion detection performance.
The impact of pension reform on employment, retirement, and disability insurance claims
Authors: Hernæs Erik , Markussen Simen , Piggott John , Røed Knut 
Published: November 2024

AbstractWe evaluate the 2011 comprehensive reform of Norwegian early retirement institutions using a parsimonious random utility choice model. Conditional on employment at age 60, we estimate a three-state conditional logit model to explain the realized labor market state at age 63 among the alternatives of employment, retirement, and disability program participation. The reform radically changed work incentives and/or pension access age for some (but not all) workers, such that the influence of economic incentives can be identified based on reform-generated variation only. We find that improved work incentives caused employment rates to rise considerably at the expense of early retirement and exit through disability insurance. Improved liquidity through a lower age to access own pension funds on actuarially neutral terms caused a small increase in employment and a large drop in disability program participation. Properly designed pension reforms thus need to take the interplay between old-age pension and disability insurance programs into account.
Municipal efficiency spillovers in France
Authors: Piedra-Peña Juan , Breuillé Marie-Laure , Gallo Julie Le 
Published: November 2024

AbstractThis paper provides evidence of the role of efficiency spillovers between French municipalities assessed through four levels of municipal equipment. We investigate changes in municipal efficiency for both cities possessing a certain level of public goods and cities located closer to those hosting high-rank functions. Based on a cross-sectional database pertaining to French municipalities with over 3500 inhabitants in 2018, we develop a two-stage approach. In the first stage, we estimate municipal efficiency through a robust order-m approach, while in the second stage, we run a truncated bootstrapped regression to disentangle the effect of the distance of an observed municipality to each of the four equipment levels. Our results provide evidence of efficiency spillovers where the less-endowed municipalities benefit the most from higher efficiency due to their geographical proximity to larger equipment centers.
E-Scooter-Fahrten unter Substanzeinfluss im Einzugsgebiet von Würzburg – eine erste verkehrsmedizinische Auswertung nach 4,5 Jahren
Authors: Stock Benjamin , Manthey Laura , Tatschner Thomas , Bohnert Michael , Bohnert Simone 
Published: November 2024

Zusammenfassung

Hintergrund
E‑Scooter sind seit über 4,5 Jahren Teil des Straßenverkehrs in Deutschland und haben seitdem in der polizeilichen Verkehrskontrolle zunehmend an Bedeutung gewonnen [16]. Das Ziel der vorliegenden Arbeit war es, eine Erstbeschreibung über die im Institut für Rechtsmedizin der Universität Würzburg bearbeiteten Fälle anzufertigen.

Materialien und Methoden
Alle Fahrsicherheitsgutachten über E‑Scooter-Fahrer (n = 84) am Institut für Rechtsmedizin Würzburg aus dem Zeitraum Juni 2019 bis Januar 2024 wurden retrospektiv ausgewertet. Hierbei wurden u. a. Ausfallerscheinungen, Fahrfehler, Tatumstände und die im Blut nachgewiesenen Substanzen analysiert.

Ergebnisse
Fast alle E‑Scooter-Fahrer in unserem Kollektiv waren Männer, viele im jüngeren Alter. Die häufigsten nachgewiesenen Substanzen im Blut waren Cannabinoide, Amphetamine und Alkohol, der häufigste Grund einer Verkehrskontrolle ein fehlendes bzw. abgelaufenes Versicherungskennzeichen. Die Vorfallszeitpunkte lagen eher abends bis nachts und zu wärmeren Jahreszeiten. Die Beschuldigten waren bei der späteren ärztlichen Untersuchung weniger leistungsreduziert als bei der polizeilichen.

Diskussion
Im Vergleich zu früheren E‑Scooter-Studien untersuchte diese Arbeit auch den Einfluss von Drogen auf die Fahrsicherheit. Die retrospektive Datenanalyse ergab z. T. ähnliche Tendenzen z. B. bezüglich Alter, Geschlecht und jahreszeitlicher Verteilung, z. T auch Unterschiede. Weitere Studien zum Einfluss von Drogen auf E‑Scooter-Fahren erscheinen vor diesem Hintergrund unabdinglich.
On the ergodicity of the frame flow on even-dimensional manifolds
Authors: Cekić Mihajlo , Lefeuvre Thibault , Moroianu Andrei , Semmelmann Uwe 
Published: November 2024

AbstractIt is known that the frame flow on a closed $n$
n
-dimensional Riemannian manifold with negative sectional curvature is ergodic if $n$
n
is odd and $n \neq 7$
n
≠
7
. In this paper we study its ergodicity in the remaining cases. For $n$
n
even and $n \neq 8, 134$
n
≠
8
,
134
, we show that:

if $n \equiv 2$
n
≡
2
mod 4 or $n=4$
n
=
4
, the frame flow is ergodic if the manifold is $\sim 0.3$
∼
0.3
-pinched,

if $n \equiv 0$
n
≡
0
mod 4, it is ergodic if the manifold is $\sim 0.6$
∼
0.6
-pinched.

In the three dimensions $n=7,8,134$
n
=
7
,
8
,
134
, the respective pinching bounds that we need in order to prove ergodicity are 0.4962..., 0.6212..., and 0.5788.... This is a significant improvement over the previously known results and a step forward towards solving a long-standing conjecture of Brin asserting that 0.25-pinched even-dimensional manifolds have an ergodic frame flow.
Refractive outcomes for secondary sutureless posterior chamber lens implantation: sutureless scleral fixating lens Carlevale® versus retropupillary iris-claw lens Artisan®
Authors: Bontemps Justine , Loria Olivier , Sejournet Lucas , Allignet Benoit , Elbany Sandra , Matonti Frédéric , Burillon Carole , Denis Philippe , Kodjikian Laurent , Mathis Thibaud 
Published: November 2024

Abstract
Purpose
To compare refractive outcomes of the foldable intraocular lens sutureless scleral fixated sutureless (Carlevale® FIL-SSF) with the iris-claw lens (Artisan®).

Methods
This retrospective study included consecutive patients who underwent a FIL-SSF implantation or an iris-claw implantation between January 2020 and November 2022 in the ophthalmology departments of Hospices Civils de Lyon (France).

Results
A total of 271 eyes from 265 patients were included: 96 eyes in the FIL-SSF group and 175 eyes in the iris-claw group. At 6 months, the mean (SD) surgically induced astigmatism (SIA) was significantly lower in the FIL-SSF group with 0.3 (1.8) diopters against 0.8 (2.1) diopters in the iris-claw group (p = 0.01). The mean (SD) refractive error was also lower for the FIL-SSF group with 0.1 (1.2) diopters versus 0.5 (1.6) diopters in the iris-claw group (p < 0.001). The mean best corrected visual acuity at 6 months was not significantly different between FIL-SSF and iris-claw lens with 0.47 (0.58) logMAR and 0.39 (0.55) logMAR, respectively (p = 0.12). However, the mean (SD) operative time was longer for FIL-SSF implantation in comparison to iris-claw implantation (59.8 (21.1) minutes versus 41.9 (24.4) minutes, respectively (p < 0.001)). The rate of postoperative complications was similar between the two techniques.

Conclusion
This study shows that FIL-SSF achieves better refractive results than iris-claw lens, with a similar rate of postoperative complications. As a relatively new implantation technique, there is a learning curve required to reduce operating time.

Key messages
What is known?

Multiple surgical options for correcting aphakia in the absence of capsular support can be used.

Currently, foldable intraocular lens sutureless scleral fixated sutureless (FIL-SSF, Carlevale®) and iris-claw (Artisan®) implants are the two preferred options, but there is no consensus on the best technique to adopt.

What is new?

We showed that FIL-SSF has a significantly lower surgically induced astigmatism compared to the iris-claw implant.

Similar rate of postoperative complications was found between these two techniques.

Future studies with a longer follow-up period are needed to ascertain its tolerance.
Serological and molecular detection of Toxoplasma gondii and Neospora caninum in ruminants from Somalia
Authors: Kakimori Monica T. A. , Osman Aamir M. , Silva Ana C. S. , Ibrahim Abdalla M. , Shair Mohamed A. , Cavallieri Ana C. , Barros Luiz D. , Garcia João L. , Vieira Thállitha S. W. J. , Hassan-Kadle Ahmed A. , Vieira Rafael F. C. 
Published: November 2024

AbstractToxoplasma gondii and Neospora caninum infect a wide range of domestic and wild animals, including humans, in the case of T. gondii, and cause economic losses in livestock due to abortion and neonatal mortality. In Somalia, zoonotic diseases are concerning due to cultural practices and livestock’s economic importance, but surveillance is limited. This study aimed to determine the seroprevalence and molecular prevalence of T. gondii and N. caninum in Somali sheep, goats, and cattle. A cross-sectional study was conducted between December 2018 and January 2020 in Benadir and Lower Shabelle regions of Somalia. Blood samples were collected from 128 cattle, 184 goats, and 46 sheep. Serum samples were tested for anti-T. gondii and anti-N. caninum antibodies using IFAT, and PCR was performed on extracted DNA to detect T. gondii and N. caninum DNA. Overall, 106/358 (29.6%) animals tested positive for anti-T. gondii antibodies, with the highest prevalence in sheep (62.5%), followed by goats (30.4%) and cattle (15.6%) (P < 0.001). For anti-N. caninum antibodies, 13/358 (3.6%) animals tested positive, with cattle showing the highest prevalence (6.2%), followed by goats and sheep (both 2.2%). Co-seropositivity for both antibodies was found in cattle and sheep. Molecular detection of T. gondii DNA revealed a prevalence of 9/358 (2.5%), primarily in sheep (15.2%) and cattle at 1.6% while all goat samples tested negative. No samples were positive for the N. caninum Nc5 gene. This study reveals T. gondii and N. caninum prevalence in Somali ruminants, highlighting the need for better surveillance and control.
Open-label, controlled, phase 2 clinical trial assessing the safety, efficacy, and pharmacokinetics of INM004 in pediatric patients with Shiga toxin-producing Escherichia coli–associated hemolytic uremic syndrome
Authors: Fayad Alicia , Principi Iliana , Balestracci Alejandro , Alconcher Laura , Coccia Paula , Adragna Marta , Amoreo Oscar , Bettendorff María Carolina , Blumetti María Valeria , Bonany Pablo , Tonfi María Laura Flores , Flynn Luis , Ghezzi Lidia , Montero Jorge , Ramírez Flavia , Seminara Claudia , Suarez Ángela , Spizzirri Ana Paula , Rivas Marta , Pichel Mariana , Zylberman Vanesa , Spatz Linus , Massa Carolina , Valerio Marina , Sanguineti Santiago , Colonna Mariana , Roubicek Ian , Goldbaum Fernando ,   on behalf of INM004 Study Group
Published: November 2024

Abstract

Background
Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS) is a severe condition mainly affecting children. It is one of the leading causes of acute kidney injury in the pediatric population. There is no established therapy for this disease. INM004 is an anti-Shiga toxin composed of equine polyclonal antibodies. This study is aimed at assessing the safety, pharmacokinetics, and efficacy of INM004 in pediatric patients with STEC-HUS.

Methods
Phase 2, open-label clinical trial with an historical control arm. Patients in the treatment arm received two doses of INM004. The primary endpoints were the safety profile, pharmacokinetics, and efficacy (dialysis days) of INM004. Secondary endpoints included other kidney and extrarenal outcomes. Propensity score matching was used for efficacy comparisons between arms.

Results
Fifty-seven and 125 patients were enrolled in the treatment and control arm, respectively. After propensity score matching, 52 patients remained in each arm. INM004 was well-tolerated. Eight adverse events were considered possibly related, none of which were serious or severe. In the primary efficacy endpoint, patients of the treatment arm presented a non-statistically significant difference of two dialysis days. On secondary endpoints, non-statistically significant trends toward fewer patients needing dialysis and dialysis for more than 10 days, and shorter time to glomerular filtration rate normalization, were observed favoring the treatment arm.

Conclusions
INM004 showed an adequate safety profile. Efficacy non-statistically significant trends suggesting a beneficial effect in the amelioration of kidney injury were observed. These results encourage the conduction of a phase 3 study of INM004 in pediatric patients with STEC-HUS.

Graphical Abstract
Acute myeloid leukemia in the next-generation sequencing era
Authors: Wurm Sonja , Waltersdorfer Michael , Loindl Simone , Moritz Jennifer M. , Herzog Sereina A. , Bachmaier Gerhard , Berghold Andrea , Kashofer Karl , Beham-Schmid Christine , Hoefler Gerald , Greinix Hildegard T. , Wölfler Albert , Reinisch Andreas , Sill Heinz , Zebisch Armin 
Published: November 2024

Summary
Background
Next-generation sequencing (NGS) has recently entered routine acute myeloid leukemia (AML) diagnostics. It is paramount for AML risk stratification and identification of molecular therapeutic targets. Most NGS feasibility and results data are derived from controlled clinical intervention trials (CCIT). We aimed to validate these data in a real-world setting.

Patients, materials and methods
This study retrospectively analyzed 447 AML patients treated at an Austrian tertiary cancer care center. A total of 284 out of the 447 cases were treated between 2013–2023 when NGS was locally available for the clinical routine.

Results
The NGS was successfully performed from bone marrow biopsies and aspirates, with processing times decreasing from 22 days in 2013/2014 to 10 days in 2022. Molecular therapeutic target(s) were identified by NGS in 107/284 (38%) cases and enabled risk stratification in 10 cases where conventional karyotyping failed. Concerning molecular landscape, TET2 (27%), FLT3 (25%), DNMT3A (23%), and NPM1 (23%) were most frequently mutated. Comparing older and younger patients (cut-off 70 years) showed enrichment in older people for mutations affecting DNA methylation (72% vs. 45%; P < 0.001) and the spliceosome (28% vs. 11%; P = 0.006) and more cellular signaling mutations in younger patients (61% vs. 46%; P = 0.022). Treatment outcomes corroborated a significant survival benefit in the recent NGS era and patients treated with novel/molecularly targeted drugs. Ultimately, biospecimens of these patients are stored within a leukemia biobank, generating a valuable tool for translational science.

Conclusion
Our study validates data from CCIT and supports their relevance for treatment decisions in a real-world setting. Moreover, they demonstrate the feasibility and benefits of NGS within a routine clinical setting.
Attention control in the peripartum period: a longitudinal study
Authors: Emesh Tamar Bakun , Meiran Nachshon , Ran-Peled Dar , Ben-Zion Hamutal , Horwitz Avel , Finkelstein Omer , Tikotzky Liat 
Published: November 2024

Abstract
Purpose
Given research inconsistency, this study aimed to assess whether attention control changes from pregnancy to postpartum, focusing on the moderating role of maternal objective and subjective sleep. Our second objective was to evaluate attention control’s role in predicting psychological outcomes in peripartum women.

Method
A cohort of 224 pregnant women completed the Antisaccade task, a measure of attention control, during the third trimester and again four months post-delivery. Objective and subjective sleep were measured using actigraphy and sleep diaries. Participants also completed questionnaires assessing depression, anxiety, emotion regulation, and maternal perceptions of the mother-infant relationship.

Results
Attention control improved significantly from late pregnancy to postpartum (β = 0.91, p < .001). While objective sleep was not linked to attention control, poorer between-person subjective sleep was associated with better postpartum attention control (β = − 0.84, p < .001). Better within-person subjective sleep was associated with higher attention control during pregnancy (β = 0.87, p < .001), but a negative interaction with time (β = -1.5, p = .001) suggests a reverse trend postpartum. Attention control did not predict postpartum psychological outcomes.

Conclusion
Cognitive recovery may occur by four months postpartum, although the observed improvement could reflect practice effect. The novel finding of a negative association between subjective sleep and postpartum attention control may indicate better adaptation to perceived poor sleep or heightened attunement to sleep fluctuations in women with higher attention control. Attention control did not predict psychological outcomes, suggesting other factors may be more critical for maternal coping postpartum.