bluuebunny/crossref_metadata_2025_split huggingface dataset:
Not all justices are equal: the unique effects of organizational justice on the behaviour and attitude of government workers in Ghana
Authors: Kumasey Anthony Sumnaya , Delle Eric , Hossain Farhad 
Published: June 2019

Drawing on social exchange and positive emotions theories, we examined the differential effects of organizational justice on work engagement and organizational commitment among 347 Ghanaian public-sector workers. We hypothesized that three different components of organizational justice (distributive, procedural and interactional) would have different effects on work engagement and organizational commitment. We used regression test to investigate these effects. Despite subtle differences, the results show that distributive and procedural justice relate positively to vigour, dedication and absorption. However, interactional justice was unrelated to any of the work engagement components. We further observed that while distributive, procedural and interactional justice related positively to affective commitment, no other type of organizational justice related to continuance and normative commitment. Overall, not all justices create the same effect on workplace behaviour. Implications and limitations are discussed. Points for practitioners • Distributive justice and procedural justice (but not interactional justice) stimulate the levels of vigour, dedication and absorption among Ghanaian public-sector workers and produce an engaged workforce. Thus, management should channel investment into the creation and implementation of administrative practices that promote the perception of fairness in the distribution of resources within organizations. • Organizational justice enhances affective commitment – the emotional connection to and identification with their organization – among public-sector workers in Ghana.
Use of the STOPP and START criteria to address polypharmacy for elderly patients in University Hospital Lewisham Clinical Decisions Unit
Authors: O’Connor Johanna , Adabavazeh Babak , Choi Hyun , Khan Akthar , Shah Sahil , Shah Shahnal 
Published: June 2019

Background: Polypharmacy and inappropriate prescribing are risk factors for adverse drug reactions, which commonly cause complications in older people. The STOPP (Screening Tool of Older Persons’ Prescriptions)/START (Screening Tool to Alert Doctors to Right Treatment) criteria are screening tools, which aim to improve prescribing in the elderly. Objectives: The aim was to improve prescribing, using the STOPP/START criteria, for patients aged 65 and above, who were admitted to the Clinical Decisions Unit at University Hospital Lewisham. We focused on the most common prescribing errors in clinical decision unit, an emergency medicine department. Methods: We reviewed all patients aged 65 and above admitted to the Clinical Decisions Unit in September. Data was collected from clinical documentation and archived drug charts. This pilot study of 114 patients revealed the most common prescribing errors, of which 8 were STOPP and 11 were START criteria. A plan–do–study–act methodology was implemented over 1 month, involving presentations, emails and posters. Prescribing patterns were then reviewed over 4 weeks in December in 111 patients. Results: Focusing on the 8 STOPP and 11 START criteria, there was a significant reduction in the proportion of patients with at least one STOPP error (17.5% to 9%, p = 0.04). However, the decrease in the percentage of patients with at least one START error was insignificant (24.6% to 20.7%, p = 0.24). Conclusion: By identifying problematic areas of prescribing and using targeted interventions, the proportion of STOPP errors made in clinical decision unit reduced significantly. This study highlights the prevalence of prescription errors in the clinical decision unit and the impact of using screening tools to reduce incorrect prescribing.
A Systemic Review of Couple Therapy Research in Greater China
Authors: Chan Tak Mau Simon , Lau Victor , Chin Fung Forward , Ho Chi Ming Mathew 
Published: June 2019

Objective: This article aims to explore the development of scholarly articles relating to couple therapy in Greater China in academic journals in the past four decades between 1976 and 2016. Method: This review analyzes 278 couple therapy articles with a focus on the question of “who are the authors?” and “what kinds of articles published?” Results: The volume of Taiwan, Mainland China, Hong Kong, and Macau articles are 90, 88, 64, and 0, respectively; 190 of them are group authorship, and the first research was published in 1984. Women are 3 times more likely than men to be the key target group, and almost two third of the works are identified as academic-led research. Conclusions: Indigenization of couple therapy research in Greater China with reference to its social and political context is addressed. The motto is, “think global but act local and promote the local to inform the global.”
Utilization patterns and clinical outcomes of rasburicase administration according to tumor risk stratification
Authors: Khalighi Parisa R , Martens Kylee L , White Andrew A , Li Shan , Silgard Emily , Frieze Deborah , Garcia David A , Li Ang 
Published: June 2019

Purpose Current guidelines for tumor lysis syndrome management recommend rasburicase for high-risk patients. Adherence to guidelines has not been well studied, and the correlation between uric acid reduction and clinically relevant outcomes, such as acute kidney injury, remains unclear. Our study aims to describe rasburicase utilization patterns and outcomes in cancer patients with varying risks for tumor lysis syndrome. Methods In this retrospective cohort study, we included cancer inpatients who received rasburicase for tumor lysis syndrome management at two affiliated academic hospitals from 2009 to 2015. Patients were classified by tumor lysis syndrome risk categories prior to drug administration. Primary outcomes included acute kidney injury incidence and renal recovery. Secondary outcomes included uric acid nadir, mortality, and hospital length-of-stay. Results Among 164 patients, 42 (26%) had high-, 63 (38%) had intermediate-, and 59 (36%) had low-risk for tumor lysis syndrome. A total of 94 patients (57%) had existing renal dysfunction prior to rasburicase use. This occurred more frequently in low- (68%) compared to intermediate- (57%) and high- (43%) risk patients ( p = 0.044). A greater proportion of patients in the high-risk group (78%) had renal recovery when compared to the intermediate- (61%) or low- (45%) risk groups ( p = 0.056). Despite a similar length of stay, the high-risk group had a significantly lower 30-day mortality (10%) when compared to intermediate- (25%) or low- (32%) risk groups ( p = 0.029). Conclusions Our results suggest that rasburicase may be frequently prescribed to treat hyperuricemia unrelated to tumor lysis syndrome in cancer patients. Improved education and adherence to guidelines may improve clinical and economic outcomes associated with rasburicase administration.
Availability of orthodontic smartphone apps
Authors: Siddiqui Nausheen Rashida , Hodges Samantha , Sharif Mohammad Owaise 
Published: June 2019

Objective: To identify and profile the available orthodontic smartphone apps published on the UK Apple App Store and Google Play Store. Design: A review of available smartphone apps. Setting: London, UK Methods: The Apple App Store and Google Play Store were accessed in October 2018; all orthodontic apps with a title and description available in English were included. Each app was classified according to the following criteria: name; target audience (patient or clinician); focus; platform (Apple App Store and/or Google Play Store); cost; rating and number of ratings; size; creation date; country of development and developer. Results: A total of 305 orthodontic related apps were identified for inclusion. The majority of apps were aimed at patients (n = 241) and the most of these were focussed on gaming (n = 136), many apps were also found to be developed by specialist practices (n = 63) and to provide knowledge for patients (n = 56). Two hundred and ninety-five apps were free, with some of these including the option of paying for in-app purchases. Most apps were developed in the USA (n = 84). Conclusions: There has been an increase in the availability of orthodontic apps in recent years. The majority of available apps are patient-focused, most commonly games. A number of apps aim to elicit a behaviour change in our patients; therefore, there is a need to assess the quality and educational content of these.
Water on Fire: The Patients’ Lived Experience of Primary Percutaneous Coronary Intervention
Authors: Javadi-Pashaki Nazila , Salari Arsalan , Emami Sigaroudi Abdolhosein 
Published: June 2019

Background: The success of a coronary angioplasty in the treatment of myocardial infarction is affected by patients’ experiences. However, the experiences of the people with an emergency angioplasty have remained unknown. Objective: This study was conducted to explore the patients’ experiences of an emergency angioplasty. Method: This study was performed using the qualitative research method and interpretive phenomenological approach. Nine patients under emergency angioplasty were selected using purposeful sampling. A total of 11 deep and semistructured interviews were performed with the patients. The data were analyzed using van Manen method. Results: Five subthemes of “diagnosis shock,” “being in an emergency situation,” “trying to self-control,” “the need for reassuring care,” and “stability” formed the structure of the patients’ experiences under the main theme of “water on fire”. Water on fire was the participants’ main perception of the emergency angioplasty. Patient-centered interactions and meeting the care, supportive, and educational needs of the patients in the case of diagnosis shock lead to a pleasant experience of returning to life. Conclusion: The findings of this study may have implications for care of patients undergoing emergency cardiovascular interventions.
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing
Authors: Niazi Hira , Zoghdani Nesrine , Couty Ludovic , Leuci Alexandre , Nitzsche Anja , Allende Maria L. , Mariko Boubacar , Ishaq Rameez , Aslan Yetki , Becker Pierre Hadrien , Gazit Salomé L. , Poirault-Chassac Sonia , Decouture Benoit , Baudrie Veronique , De Candia Erica , Kono Mari , Benarab Ammar , Gaussem Pascale , Tharaux Pierre-Louis , Chun Jerold , Provot Sylvain , Debili Najet , Therond Patrice , Proia Richard L. , Bachelot-Loza Christilla , Camerer Eric 
Published: June 2019

Abstract
The bioactive lipid mediator sphingosine 1-phosphate (S1P) was recently assigned critical roles in platelet biology: whereas S1P1 receptor-mediated S1P gradient sensing was reported to be essential for directing proplatelet extensions from megakaryocytes (MKs) toward bone marrow sinusoids, MK sphingosine kinase 2 (Sphk2)–derived S1P was reported to further promote platelet shedding through receptor-independent intracellular actions, and platelet aggregation through S1P1. Yet clinical use of S1P pathway modulators including fingolimod has not been associated with risk of bleeding or thrombosis. We therefore revisited the role of S1P in platelet biology in mice. Surprisingly, no reduction in platelet counts was observed when the vascular S1P gradient was ablated by impairing S1P provision to plasma or S1P degradation in interstitial fluids, nor when gradient sensing was impaired by S1pr1 deletion selectively in MKs. Moreover, S1P1 expression and signaling were both undetectable in mature MKs in situ, and MK S1pr1 deletion did not affect platelet aggregation or spreading. When S1pr1 deletion was induced in hematopoietic progenitor cells, platelet counts were instead significantly elevated. Isolated global Sphk2 deficiency was associated with thrombocytopenia, but this was not replicated by MK-restricted Sphk2 deletion and was reversed by compound deletion of either Sphk1 or S1pr2, suggesting that this phenotype arises from increased S1P export and S1P2 activation secondary to redistribution of sphingosine to Sphk1. Consistent with clinical observations, we thus observe no essential role for S1P1 in facilitating platelet production or activation. Instead, S1P restricts megakaryopoiesis through S1P1, and can further suppress thrombopoiesis through S1P2 when aberrantly secreted in the hematopoietic niche.
Truly sustainable or not? An exploratory assessment of sustainability capability of textile and apparel corporations in China from the moral responsibility perspective
Authors: Yang Nannan , Ha-Brookshire Jung E. 
Published: June 2019

AbstractWithin the moral responsibility theory of corporate sustainability (MRCS) framework (Ha-Brookshire in J Bus Ethics, 2015. https://doi.org/10.1007/s10551-015-2847-2), the study examined 86 sustainability reports from top performing textile and apparel companies in China to explore their perceptions and sustainability capability implications. Content analysis of their sustainability reports was conducted to analyze whether each company (a) perceives sustainability as a perfect duty or not, (b) has clear goals toward sustainability or not, and (c) has well-defined structures toward sustainability goals or not. Results show that 66 of the 86 reports described sustainability as a perfect duty to fulfill; 11 described as an imperfect duty, and 9 described no opinions about sustainability. Of the 66 reports, 19 explicitly showed clear goals and the evidence of organizational structures toward such goals, leading us to categorize them as truly sustainable corporations as Ha-Brookshire (2015) described. Of the 66, 43 lacked clear sustainability goals, leading us to categorize them as occasionally sustainable corporations as described by Ha-Brookshire (2015). Other firms were also categorized within the MRCS framework. Findings show a spectrum of Chinese textile and apparel companies’ sustainability capability from the moral responsibility perspective.
Conjugated Estrogens and Bazedoxifene Improve β Cell Function in Obese Menopausal Women
Authors: Lovre Dragana , Peacock Erin , Katalenich Bonnie , Moreau Cynthia , Xu Beibei , Tate Chandra , Utzschneider Kristina M , Gautier Jean-François , Fonseca Vivian , Mauvais-Jarvis Franck 
Published: June 2019

Abstract

Context
Studies suggest that menopausal hormone therapy (MHT) prevents type 2 diabetes (T2D). The combination of conjugated estrogens (CE) with the selective estrogen receptor modulator bazedoxifene (BZA) is an MHT that improves obesity and T2D in preclinical models of menopausal metabolic syndrome. The effect of CE/BZA on adiposity and glucose homeostasis in obese postmenopausal women is unknown.

Objective
To investigate the effect of CE/BZA on body composition, glucose homeostasis, and markers of inflammation in obese postmenopausal women.

Research Design, Intervention, and Participants
Randomized, double-blind, placebo-controlled pilot trial of 12 obese menopausal women assigned to 12-week treatment with CE 0.45 mg/BZA 20 mg (n = 7) or placebo (n = 5). At baseline and after 12 weeks, we assessed body composition (dual-energy X-ray absorptiometry), glucose homeostasis (IV glucose tolerance test), and inflammation biomarkers.

Results
Women treated with CE/BZA exhibited increased β cell function using homeostatic model assessment-B [median (interquartile range) CE/BZA vs placebo: 18.5 (−0.9 to 320.6) μU/mM vs −25.5 (−39.9 to −0.1) μU/mM; P = 0.045], and decreased basal glucose concentrations (Gb) [−5.2 (−9.2 to −1.7) mg/dL vs 2.7 (0.9 to 4.9) mg/dL; P = 0.029]. Insulin sensitivity was higher in the placebo arm [1.35 (1.12 to 1.82) (μU/mL) min−1 vs −0.24 (−1.50 to 0.19) (μU/mL) min−1; P = 0.029]. No changes between treatment groups were observed for the acute insulin response to glucose (AIRg), the disposition index (DI), body composition, and inflammatory biomarkers.

Conclusions
A 12-week treatment of obese postmenopausal women with CEs/BZA improves fasting β cell function and glucose concentrations without change in AIRg, HOMA-IR, DI, body composition, or markers of inflammation.
Case Report: Resolution of chronic urticaria following treatment of odontogenic infection
Authors: Tadros Susan , Bahal Sameer , Nagendran Vasantha 
Published: June 2019

Background: Chronic spontaneous urticaria (CSU) is a condition characterised by the presence of hives with/without angioedema, that affects individuals on more days than not for 6 weeks or more. The role of infection as a potential trigger for CSU is well described, but the current clinical guidelines do not recommend routine screening for underlying infections. Main observations: We report a case of severe prolonged chronic spontaneous urticaria in a 19-year-old, that went into rapid remission following the treatment of dental infection. Conclusions: Clinicians should recognise the potential role that infection can have in causing chronic urticaria. There should be a low threshold to treat infection in such circumstances.
Exploring the perspectives of stroke survivors and healthcare professionals on the use of mobile health to promote physical activity: A qualitative study protocol
Authors: Carter Daniel D. , Robinson Katie , Forbes John , Walsh Jane C. , Hayes Sara 
Published: June 2019

Background: Physical inactivity is both the second-highest population attributable risk factor for and a common consequence of stroke. Despite well-documented health benefits associated with physical activity, its levels typically remain below recommended guidelines in stroke survivors. Consequently, calls have been made for novel interventions targeting the promotion of physical activity in stroke survivors. Mobile health is an emerging field which can offer personalised health interventions through mobile and wireless technology. However, a paucity of research has focused on mobile health to promote physical activity in stroke survivors and, more broadly, this field has been criticised for not incorporating the views of stakeholders. This study aims to explore the perspectives of stroke survivors and healthcare professionals on the development of a mobile health intervention for the promotion of physical activity. Methods: The current study will employ a qualitative descriptive approach using separate, semi-structured focus groups for two key stakeholder groups. Community-dwelling stroke survivors will be recruited through an early supported discharge service for acute stroke and stroke support groups. Healthcare professionals will be recruited through the same early supported discharge service, relevant professional bodies and Twitter. The final number of focus groups will depend on data saturation. Thematic analysis will be conducted using NVivo 12 and findings will be reported in accordance with the Consolidated Criteria for Reporting Qualitative Studies. Conclusion: This study was granted ethical approval from the HSE Mid-Western Regional Hospital Research Ethics Committee and the Faculty of Education and Health Sciences Research Ethics Committee at the University of Limerick. Output will consist of recommendations for the development of a mobile health intervention aimed at the promotion of physical activity in stroke survivors. Findings will be disseminated locally through presentations at stroke support groups, as well as internationally through academic conferences and peer-reviewed journals.
ZMYM2 inhibits NANOG-mediated reprogramming
Authors: Lawrence Moyra , Theunissen Thorold W. , Lombard Patrick , Adams David J. , Silva José C. R. 
Published: June 2019

Background: NANOG is a homeodomain-containing transcription factor which forms one of the hubs in the pluripotency network and plays a key role in the reprogramming of somatic cells and epiblast stem cells to naïve pluripotency. Studies have found that NANOG has many interacting partners and some of these were shown to play a role in its ability to mediate reprogramming. In this study, we set out to analyse the effect of NANOG interactors on the reprogramming process. Methods: Epiblast stem cells and somatic cells were reprogrammed to naïve pluripotency using MEK/ERK inhibitor PD0325901, GSK3β inhibitor CHIR99021 and Leukaemia Inhibitory Factor (together termed 2i Plus LIF). Zmym2 was knocked out using the CRISPR/Cas9 system or overexpressed using the PiggyBac system. Reprogramming was quantified after ZMYM2 deletion or overexpression, in diverse reprogramming systems. In addition, embryonic stem cell self renewal was quantified in differentiation assays after ZMYM2 removal or overexpression. Results: In this work, we identified ZMYM2/ZFP198, which physically associates with NANOG as a key negative regulator of NANOG-mediated reprogramming of both epiblast stem cells and somatic cells. In addition, ZMYM2 impairs the self renewal of embryonic stem cells and its overexpression promotes differentiation. Conclusions: We propose that ZMYM2 curtails NANOG’s actions during the reprogramming of both somatic cells and epiblast stem cells and impedes embryonic stem cell self renewal, promoting differentiation.
Gravity-induced exercise intervention in an individual with chronic fatigue syndrome/myalgic encephalomyeltis and postural tachycardia syndrome: a case report
Authors: Ballantine Robert , Strassheim Victoria , Newton Julia 
Published: June 2019

Background/Aims Chronic fatigue syndrome/myalgic encephalomyeltis is a condition of complex nature, characterised by unexplained disabling fatigue and a combination of non-specific accompanying symptoms. Individuals with chronic fatigue syndrome/myalgic encephalomyeltis frequently present with debilitating orthostatic symptoms, which may fall under the umbrella of postural tachycardia syndrome. Postural tachycardia syndrome is underpinned by autonomic nervous system dysfunction. The gravitational deconditioning that occurs in those severely affected by chronic fatigue syndrome/myalgic encephalomyeltis alongside postural tachycardia syndrome has been suggested as a key focus for interventions in this group. This case report documents the evaluation and rationale behind a novel gravity-induced exercise intervention to improve the symptoms of a 44-year-old female severely affected by chronic fatigue syndrome/myalgic encephalomyeltis and postural tachycardia syndrome, who had been bedbound for 10–15 years. Methods An exercise intervention was designed to challenge and therefore improve key areas of autonomic nervous system regulation in the presence of gravity. It contained seven different exercises conducted once a month in a class over a 6-month period. Results Fatigue impact score, activity levels and heart rate upon standing, as detected by an active stand test, improved during the exercise intervention and at follow up. Conclusions Gravity-induced exercise intervention can have a positive effect on an individual severely affected by Chronic fatigue syndrome/myalgic encephalomyeltis alongside postural tachycardia syndrome.
Recognising and treating arrhythmias in primary care
Authors: Richley Dave 
Published: June 2019

As more and more people in the UK are being affected by cardiovascular conditions, it is increasingly necessary for practice nurses to keep up-to-date with the latest developments. Dave Richley explains common ECG readings that may be seen in primary care Cardiac arrhythmias may be asymptomatic or they may be responsible for a range of symptoms including palpitations, dizziness, chest pain and loss of consciousness. Accurate diagnosis, and therefore appropriate management, depends on careful interpretation of an electrocardiogram (ECG) recording of the arrhythmia, and this is often achievable in primary care. This article presents the arrhythmias most commonly encountered in primary care, as well as those seen rarely, and describes and illustrates their defining features. It will also discuss some of the pitfalls that can lead to erroneous diagnosis. While some arrhythmias can be managed appropriately in primary care, guidance is provided in regarding referral or admission to hospital for arrhythmias that may warrant further investigation or specialist care.