bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Electrophysiological Correlates of Incessant Ivabradine-Sensitive Atrial Tachycardia
Authors: Banavalikar Bharatraj , Shenthar Jayaprakash , Padmanabhan Deepak , Valappil Sanjai Pattu , Singha Sinam Inaoton , Kottayan Anju , Ghadei Milan , Ali Muzaffar 
Published: July 2019

Background:
Incessant focal atrial tachycardia (FAT), if untreated, can lead to ventricular dysfunction and heart failure (tachycardia-induced cardiomyopathy). Drug therapy of FAT is often difficult and ineffective. The efficacy of ivabradine has not been systematically evaluated in the treatment of FAT.

Methods:
The study group consisted of patients with incessant FAT (lasting >24 hours) and structurally normal hearts. Patients with ventricular dysfunction as a consequence of FAT were not excluded. All antiarrhythmic drugs were discontinued at least 5 half-lives before the initiation of ivabradine. Oral ivabradine (adults, 10 mg twice 12 hours apart; pediatric patients: 0.28 mg/kg in 2 divided doses) was initiated in the intensive care unit under continuous electrocardiographic monitoring. A positive response was defined as the termination of tachycardia with the restoration of sinus rhythm or suppression of the tachycardia to <100 beats per minute without termination within 12 hours of initiating ivabradine.

Results:

Twenty-eight patients (mean age, 34.6±21.5 years; women, 60.7%) were included in the study. The most common symptom was palpitation (85.7%) followed by shortness of breath (25%). The mean atrial rate during tachycardia was 170±21 beats per minute, and the mean left ventricular ejection fraction was 54.7±14.3%. Overall, 18 (64.3%) patients responded within 6 hours of the first dose of ivabradine. Thirteen of 18 ivabradine responders subsequently underwent successful catheter ablation. FAT originating in the atrial appendages was a predictor of ivabradine response compared with those arising from other atrial sites (
P
=0.046).

Conclusions:
Ivabradine-sensitive atrial tachycardia constitutes 64% of incessant FAT in patients without structural heart disease. Incessant FAT originating in the atrial appendages is more likely to respond to ivabradine than that arising from other atrial sites. Our findings implicate the funny current in the pathogenesis of FAT.
Better Prognosis After Complete Revascularization Using Contemporary Coronary Stents in Patients With Chronic Kidney Disease
Authors: Hwang Doyeon , Kang Jeehoon , Yang Han-Mo , Yang Seokhun , Park Jiesuck , Han Jung-Kyu , Kang Hyun-Jae , Koo Bon-Kwon , Kim Hyo-Soo 
Published: July 2019

Background:
The prognostic value of angiographic complete revascularization in patients with chronic kidney disease (CKD) has not been thoroughly investigated, especially for contemporary coronary stents. We compared the clinical outcomes of complete and incomplete revascularization with second-generation drug-eluting stent, according to the presence of CKD.

Methods:
From the Grand Drug-Eluting Stent Registry (N=17 286) in Korea, we selected 8471 patients, who were treated with second-generation drug-eluting stent and had glomerular filtration rate and quantitative coronary angiography data (3014 [35.6%] patients with CKD and 5457 (64.4%) patients with preserved renal function). Angiographic complete revascularization was defined as a residual SYNTAX score (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) of 0. The primary outcome was the patient-oriented composite outcome at 3 years, including all-cause death, any myocardial infarction, and any revascularization.

Results:

The patient-oriented composite outcome rate after complete revascularization was significantly lower than that after incomplete revascularization in patients with CKD (14.6% versus 21.8%; adjusted hazard ratio, 0.79; 95% CI, 0.64–0.96;
P
=0.020) and in patients with preserved renal function (8.0% versus 12.0%; adjusted hazard ratio 0.77; 95% CI, 0.63–0.94;
P
=0.011). The cutoff values of residual SYNTAX scores for predicting better patient-oriented composite outcomes were different according to the presence of CKD, that is, <3 and <8 in patients with CKD and with preserved renal function, respectively.

Conclusions:
Angiographic complete revascularization led to better clinical outcomes in patients with CKD and with preserved renal function. However, the residual SYNTAX score to achieve a better outcome was lower in patients with CKD than with preserved renal function, favoring more aggressive revascularization in patients with CKD.
Cardiac Myosin‐Binding Protein C to Diagnose Acute Myocardial Infarction in the Pre‐Hospital Setting
Authors: Kaier Thomas E. , Stengaard Carsten , Marjot Jack , Sørensen Jacob Thorsted , Alaour Bashir , Stavropoulou‐Tatla Stavroula , Terkelsen Christian Juhl , Williams Luke , Thygesen Kristian , Weber Ekkehard , Marber Michael , Bøtker Hans Erik 
Published: July 2019

Background

Early triage is essential to improve outcomes in patients with suspected acute myocardial infarction (
AMI
). This study investigated whether cMyC (cardiac myosin‐binding protein), a novel biomarker of myocardial necrosis, can aid early diagnosis of
AMI
and risk stratification.

Methods and Results

cMyC
and high‐sensitivity cardiac troponin T were retrospectively quantified in blood samples obtained by ambulance‐based paramedics in a prospective, diagnostic cohort study. Patients with ongoing or prolonged periods of chest discomfort, acute dyspnoea in the absence of known pulmonary disease, or clinical suspicion of
AMI
were recruited. Discrimination power was evaluated by calculating the area under the receiver operating characteristics curve; diagnostic performance was assessed at predefined thresholds. Diagnostic nomograms were derived and validated using bootstrap resampling in logistic regression models. Seven hundred seventy‐six patients with median age 68 [58;78] were recruited.
AMI
was the final adjudicated diagnosis in 22%. Median symptom to sampling time was 70 minutes.
cMyC
concentration in patients with
AMI
was significantly higher than with other diagnoses: 98 [43;855] versus 17 [9;42] ng/L. Discrimination power for
AMI
was better with
cMyC
than with high‐sensitivity cardiac troponin T (area under the curve, 0.839 versus 0.813;
P
=0.005). At a previously published rule‐out threshold (10 ng/L),
cMyC
reaches 100% sensitivity and negative predictive value in patients after 2 hours of symptoms. In logistic regression analysis,
cMyC
is superior to high‐sensitivity cardiac troponin T and was used to derive diagnostic and prognostic nomograms to evaluate risk of AMI and death.

Conclusions

In patients undergoing blood draws very early after symptom onset,
cMyC
demonstrates improved diagnostic discrimination of
AMI
and could significantly improve the early triage of patients with suspected AMI.
Noncontrast Computed Tomography Alberta Stroke Program Early CT Score May Modify Intra-Arterial Treatment Effect in DAWN
Authors: Bhuva Parita , Yoo Albert J. , Jadhav Ashutosh P. , Jovin Tudor G. , Haussen Diogo C. , Bonafe Alain , Budzik Ronald J. , Yavagal Dileep R. , Hanel Ricardo A. , Hassan Ameer E. , Ribo Marc , Cognard Christophe , Sila Cathy A. , Morgan Patricia M. , Zhang Yanchang , Shields Ryan , Smith Wade , Saver Jeffrey L. , Liebeskind David S. , Nogueira Raul G. ,   for the DAWN Trial Investigators
Published: July 2019

Background and Purpose—
It is unknown whether noncontrast computed tomography (NCCT) can identify patients who will benefit from intra-arterial treatment (IAT) in the extended time window. We sought to characterize baseline Alberta Stroke Program Early CT Score (ASPECTS) in DAWN (DWI or CTP Assessment With Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention With Trevo) and to assess whether ASPECTS modified IAT effect.

Methods—
Core lab adjudicated ASPECTS scores were analyzed. The trial cohort was divided into 2 groups by qualifying imaging (computed tomography versus magnetic resonance imaging). ASPECTS-by-treatment interaction was tested for the trial coprimary end points (90-day utility-weighted modified Rankin Scale (mRS) score and mRS, 0–2), mRS 0 to 3, and ordinal mRS. ASPECTS was evaluated separately as an ordinal and a dichotomized (0–6 versus 7–10) variable.

Results—

Of 205 DAWN subjects, 123 (60%) had NCCT ASPECTS, and 82 (40%) had diffusion weighted imaging ASPECTS. There was a significant ordinal NCCT ASPECTS-by-treatment interaction for 90-day utility-weighted mRS (interaction
P
=0.04) and mRS 0 to 2 (interaction
P
=0.02). For both end points, IAT effect was more pronounced at higher NCCT ASPECTS. The dichotomized NCCT ASPECTS-by-treatment interaction was significant only for mRS 0 to 2 (interaction
P
=0.04), where greater treatment benefit was seen in the ASPECTS 7 to 10 group (odds ratio, 7.50 [2.71–20.77] versus odds ratio, 0.48 [0.04–5.40]). A bidirectional treatment effect was observed in the NCCT ASPECTS 0 to 6 group, with treatment associated with not only more mRS 0 to 3 outcomes (50% versus 25%) but also more mRS 5 to 6 outcomes (40% versus 25%). There was no significant modification of IAT effect by diffusion weighted imaging ASPECTS.

Conclusions—
Baseline NCCT ASPECTS appears to modify IAT effect in DAWN. Higher NCCT ASPECTS was associated with greater benefit from IAT. No treatment interaction was observed for diffusion weighted imaging ASPECTS.
Effect of Heart Rate Variability on the Association Between the Apnea-Hypopnea Index and Cerebral Small Vessel Disease
Authors: Del Brutto Oscar H. , Mera Robertino M. , Costa Aldo F. , Castillo Pablo R. 
Published: July 2019

Background and Purpose—
The apnea-hypopnea index (AHI) is associated with cerebral small vessel disease (cSVD), but pathogenesis of this association is elusive. We aimed to assess the effect of nighttime heart rate variability (HRV)—as a proxy of sympathetic upregulation—on the aforementioned association.

Methods—
Atahualpa residents aged ≥60 years undergoing brain magnetic resonance imaging, polysomnography, and 24-hour Holter monitoring (N=176) were included. The presence of moderate-to-severe white matter hyperintensities, deep cerebral microbleeds, lacunar infarcts, and >10 enlarged basal ganglia perivascular spaces were added for estimating the cSVD score. Interaction models were fitted to assess the effect modification of nighttime HRV in the association between the AHI and the cSVD score, and mediation analysis was utilized to assess the proportion of total effect by nighttime HRV on this association.

Results—

Generalized linear models showed a significant association between the AHI and the cSVD score (
P
=0.025), as well as a significant inverse association between nighttime HRV and the cSVD score (
P
=0.002), but no association between daytime HRV and the cSVD score (
P
=0.097). Interaction models showed a significant interaction of nighttime HRV on the association between AHI and the cSVD score (
P
=0.001), and mediation analysis found that the percent of total effect between AHI and cSVD score mediated by HRV was 30.8%. Predictive marginal means of the cSVD score were highly significant when the 10th percentile of nighttime HRV was compared across categories of 10th and 90th percentiles of the AHI (cSVD score margins, 0.61 [95% CI, 0.37–0.86] versus 1.67 [95% CI, 1.26–2.09]). Contour plots showed the effect of nighttime (but not daytime) HRV on the association between AHI and the cSVD score.

Conclusions—
This study shows an important effect of nighttime HRV on the association between the AHI and the cSVD score and provides further support for the role of sympathetic overactivity on this association.
John Chrysostom’s Reception of Basil of Caesarea’s Trinitarian Theology
Authors: Lai Pak-Wah 
Published: July 2019

Abstract
The last two decades have seen extensive research on the Trinitarian theologies of several post-Nicene Fathers. Not much, however, has been done for John Chrysostom. Thomas Karman and Pak-Wah Lai have demonstrated separately that Chrysostom shares several theological beliefs with the Eusebian-Meletians, including the doctrine of divine incomprehensibility, and their anti-Sabellian concerns. Stylianos Papadopoulos has claimed further that Chrysostom is a successor of both Athanasius and the Cap­padocians’ teachings. Among the Cappadocians, it was Basil of Caesarea who first allied himself with the Meletians in the 370s. This makes him a prime candidate for examining Chrysostom’s reception of Cappadocian theology. We observe, first of all, that both ­bishops operate within the Meletian tradition, employing a wide range of Eusebian motifs to denote the Trinitarian relations, including the use of hypostatic language as a safeguard against Sabellianism. Both also assume God’s nature as incomprehensible. Basil, however, also developed several theological ideas which feature prominently in Chrysostom’s homilies. Specifically, a doctrine of divine simplicity that distinguishes between the knowledge and conceptions of God’s ousia, a careful distinction between God’s ousia and hypostasis whereby the latter is taken as representing ousia in its particular properties or idiomata, the illuminating role of the Spirit, and, finally, the defence of the Son and Spirit’s full divinity by underscoring the fact that they are equal in knowledge, authority, honour, and power as the Father. Taken together, these similarities suggest strongly that Basil’s teachings loom large in Chrysostom’s Trinitarian theology.
Some Notes on the Schemes of Temporal Logics in Late Neoplatonism and in the Works of Origen and Gregory of Nyssa
Authors: Kamenskikh Aleksey 
Published: July 2019

Abstract
The article analyzes some key moments in the history of temporal logics in late antiquity (conception of integral time, relationship between temporal and eternal, extended and instant in the systems of Iamblichus, Proclus, Damascius and Simplicius), and genesis of Christian forms of temporal logics, which transform the everlasting homogenous time of κόσμος into history of universal salvation, alterate unextended νῦν, moment of psycho-physical time of late Neoplatonists, with καιρός, eschatologically charged instant of decision and act that can interrupt the continuity of time and to achieve instantaneously the end, τέλος of history.
Does the Flesh Possess Hypostatic Idioms, and If So, Why is it Then Not a Separate Hypostasis?
Authors: Krausmuller Dirk 
Published: July 2019

Abstract
This article focuses on a conceptual problem that arose from the application to Christology of the Cappadocian definition of hypostasis as substance with idioms. It discusses the solutions that were proposed by John of Caesarea, Leontius of Byzantium, John Philoponus, Leontius of Byzantium, Maximus the Confessor and John of Damascus.
Medieval Georgian Projection of Religious Historiography of Late Antiquity
Authors: Doborjginidze Nino 
Published: July 2019

Abstract
The article analyses the historical concepts of the medieval Georgian history by Leonti Mroveli, as the projection of religious historiography in Late Antiquity and the Middle Ages. Introductions to two redactions of The Georgian Chronicles have been considered. It has been shown that both versions have the same aim: to reconstruct the ethnic origin of the Georgians (our kin) from the onset of the world history and to legitimate our kin as an immediate partaker in the initial (Biblical) history. For this purpose, Leonti Mroveli uses diamerisms, a scheme of universal history (Διαμερισμὸς τῆς γῆς) employed in religious historiography from the 1st century AD. Fragments of diamerisms found in medieval Georgian historical narratives reveal that Georgian historiographers were familiar with them via Greek, Syriac, Ethiopian and Armenian versions and successfully used them to highlight the unity between the universal and their national (local) histories – the life of our kin.
The Acts of Lalibäla: a Collection of Fables or an Underestimated Historical Source?
Authors: Frantsouzoff Serge A. 
Published: July 2019

Abstract
The deeds and exploits of St. Lalibäla who was the most famous king of the Ethiopian Zagwe dynasty are still awaiting to be published in full. To the modern researchers this important medieval text is available only in excerpts published by J. Perruchon in the 19th century. The author argues that Lalibäla’s Deeds is far from being an Ethiopian folklore. They comprise valuable authentic data, e.g. the persecution of Lalibäla at the royal court, his escape into the desert, his marriage, his subsequent becoming a king, the organization of his army, taxation policies and history of construction of the famous monolithic churches in the centre of Lasta. The author also argues that the title wäldä nägaśi, which is mentioned in his Deeds as well as its parallel wld/ngšy-n found in Middle Sabaean inscriptions is a sufficient evidence in favour of the military and political continuity between the Aksumite and Zagwe epochs. The Lalibäla’s Deeds comprise many minute details about the everyday life, which suggests that the Christians of Ethiopia had a centuries long oral tradition of preserving and transmitting historical information.
The St. Sisynnios Ethiopian Legend Revisited
Authors: Gusarova Ekaterina V. 
Published: July 2019

Abstract
The St. Sisynnios legend is an integral part of both Christian and popular Ethiopian historical traditions. It is known to exist in the Ge’ez language and constitutes a part of the compilation corpus based upon the so called magic or protective scrolls. There are two versions of the vita of St. Sisynnios. The shorter one is found in the Synaxarion, whereas the longer one is included in a corpus of hagiographical compilations “The Lives of the Martyrs”. The text of the legend comprises various stories based on real facts from the Saint’s life. However only some of them have been preserved intact; others have been re-told. Until recently have been discovered only three redactions of the vita. A new redaction recently discovered by the author of this article is of a paramount importance since it changes our view on how this legend did exist indeed in the Ethiopian cultural tradition.
Teaching Atmospheric Modeling at the Graduate Level: 15 Years of Using Mesoscale Models as Educational Tools in an Active Learning Environment
Authors: Steeneveld Gert-Jan , Vilà-Guerau de Arellano Jordi 
Published: July 2019

AbstractNumerical weather prediction models have become widespread tools that are accessible to a variety of communities, ranging from academia and the national meteorological services to commercial weather providers, wind and solar energy industries, and air quality modelers. Mesoscale meteorological models that are used to refine relatively coarse global weather forecasts to finer atmospheric scales have become mainstream. The wide use of mesoscale meteorological models also generates new requirements in undergraduate education concerning the knowledge and application of these models. In this paper, we present teaching strategies, course outcomes, student activities, impacts, and reflections on the possible future direction of the graduate-level atmospheric modeling course using the Weather Research and Forecasting (WRF) Model at Wageningen University, the Netherlands. This information is based on 15 years of experience in teaching the course and the continuous implementation of new educational techniques to adapt to students’ needs and improve their chances in their academic careers and the atmospheric sciences job market.
The Absence of Degree of Automation Trade-Offs in Complex Work Settings
Authors: Jamieson Greg A. , Skraaning Gyrd 
Published: July 2019

Objective The objective of this study was to test the predictions of the routine-failure trade-off (or lumberjack) model in a full-scope simulator study with expert operators performing realistic control tasks. Background A meta-study of degree of automation (DOA) studies concluded that DOA predicts task performance under both routine and automation failure conditions, workload, and situation awareness. Empirical support for this conclusion appears to be weak for complex work situations. Method A full-scope nuclear power plant simulator experiment was conducted in which licensed operating crews completed realistic procedure execution tasks. Dependent measures selected from the lumberjack model were collected and analyzed for systematic effects. Results Situation awareness increased with increasing DOA, which contradicts the lumberjack model. Anticipated workload and failure task performance effects were not observed. Conclusion The experimental results add further evidence challenging the applicability of the lumberjack model to complex work situations. Application Practitioners should use caution when extending the predictions of the lumberjack model based on data from simple work situations to complex work situations. Researchers should invest more resources in testing the predictive power of the lumberjack model in complex work situations.
Hospice nurses request paediatric-specific educational resources and training programs to improve care for children and families in the community: Qualitative data analysis from a population-level survey
Authors: Kaye Erica C , Applegarth Jacob , Gattas Melanie , Kiefer Ashley , Reynolds Jason , Zalud Kristina , Baker Justin N 
Published: July 2019

Background: Children with serious illness who receive hospice care often interface with nurses who lack training, experience and comfort in the provision of paediatric palliative and hospice care. Hospice nurse preferences for paediatric-specific training are not well known. Aim: To describe the types of paediatric-specific training received and educational content preferred by hospice nurses. Design: Population-level dissemination of a cross-sectional survey with qualitative analysis of open-ended survey items. Setting/participants: Nurses from 71 community-based hospice organizations across 3 states completed the survey. Results: An open-ended response was provided by 278/551 (50.5%) survey respondents. A total of 55 respondents provided 58 descriptions of prior paediatric-specific training, including a formal 2-day course ( n = 36; 65.5%), on-the-job education ( n = 13, 23.6%), online training ( n = 5, 9.1%), nursing school ( n = 2, 3.6%) and paediatric advanced life support courses ( n = 2, 3.6%). A total of 67 respondents described 74 hospice-led educational efforts, largely comprised of a 2-day course ( n = 39; 54.2%) or provision of written materials ( n = 11; 15.3%). A total of 189 respondents described 258 preferences for paediatric-specific training, with nearly half ( n = 93; 49.2%) requesting ‘any’ or ‘all’ types of education and the remainder requesting education around medication use ( n = 48; 25.4%), symptom assessment/management ( n = 32; 16.9%), pain assessment/management ( n = 28; 14.8), communication ( n = 29; 15.3%) and psychosocial assessment/management ( n = 28; 14.8). Conclusions: Hospice nurses self-report inadequate exposure to educational resources and programs, in conjunction with a strong desire for increased paediatric-specific training. Identification of targetable gaps should inform the development of educational resources, policies and other supportive interventions to improve delivery of care to children and families in the community.