bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient characteristics as predictors of recurrence of atrial fibrillation following cryoballoon ablation
Authors: Bavishi Aakash A. , Kaplan Rachel M. , Peigh Graham , Diaz Celso L. , Baman Jayson R. , Trivedi Amar , Wasserlauf Jeremiah , Shen Mark J. , Sattayaprasert Prasongchai , Chicos Alexandru B. , Kim Susan , Verma Nishant , Arora Rishi , Lin Albert , Knight Bradley P. , Passman Rod S. 
Published: March 2019

AbstractBackgroundWhile several studies have evaluated predictors for atrial fibrillation (AF) recurrence following catheter ablation, there are limited data specific to cryoballoon ablation (CBA).MethodsWe analyzed a prospective registry of patients at a single institution who underwent CBA. Recurrence of AF (RAF) was defined as recurrence of AF by 12‐month follow‐up, excluding the 3‐month blanking period. Univariate analysis was performed to evaluate predictors of RAF. Receiver operating characteristic analysis was used to compare and evaluate the performance of various risk scores for discriminating risk of RAF.ResultsThere were 542 patients included in the analysis with mean age 61.3 ± 10.6 years, 67.9% male, and 51.6% paroxysmal AF (PAF). Overall, only left atrial diameter (LAD) > 40 mm and ERAF (early recurrence of AF within 0‐3 month blanking period) were significant predictors of RAF. In the PAF specific subgroup, LAD > 40 mm, AF duration > 12 months, prior stroke or transient ischemic attack, ERAF, and having previously failed an antiarrhythmic drug were significant predictors of RAF. In persistent AF (PeAF) subgroup, obstructive sleep apnea (OSA) and ERAF were significant predictors of RAF. Out of clinical risk scores tested, BASEAF2 had the highest performance with area under the curve of 0.646 (95% confidence interval [0.548, 0.708]; P < .01).ConclusionsIn this single‐center retrospective study of CBA, we found only LAD > 40 mm and ERAF to be predictors of RAF. We identified OSA as a potential targetable risk factor in PeAF patients undergoing CBA. Out of risk scores tested for discriminating risk of RAF, BASEAF2 had the best performance.
Innovation, R&D Spillovers, and the Variety and Concentration of the Local Industry Structure*
Authors: Leppälä Samuli 
Published: March 2019

AbstractThis paper presents a Cournot oligopoly model with R&D spillovers both within and across industries. The aim is to provide a theoretical foundation for the main hypotheses regarding the effect of the local industry structure on innovation and output. Depending on the spillover rates and the degree of product differentiation between the industries, the firms respond differently to changes in variety and concentration, which can explain the mixed empirical results. Furthermore, innovation and output can react in opposite ways, which makes the choice of the performance measure critical.
Spatial optimization of rural settlement relocation by incorporating inter‐village social connections under future policy scenarios
Authors: Liu Dianfeng , Kong Xuesong , Zhou Boyuan , Tian Yasi , Liu Yaolin , Wang Hua 
Published: March 2019

AbstractSocial connections between villages can represent farmers’ interests and thus benefit participatory rural relocation planning. With rural development, however, these connections will change and may weaken the adaptation of relocation plans to future rural systems. As yet, most studies still use empirical social connections to guide relocation planning, while a few have incorporated predicted connections in the context of rural development into relocation decisions. Meanwhile, spatial optimization approaches have seldom been adopted to solve this geographical decision issue. Accordingly, our study proposes a novel spatial relocation framework that incorporates changed inter‐village social connections under future rural development scenarios. Empirical inter‐village connections and their policy‐induced changes in central China were explored using social network analysis. An integration of particle swarm optimization and geographic information systems was adopted to identify the relocation solutions with maximum inter‐village connections and maximum spatial land use compactness, and to examine how connection changes under different policy scenarios influenced relocation outcomes. The results demonstrate the significance of incorporating policy‐induced social connections into relocation plans, and most importantly, show the negative relations between changed social connections and the migration distance/direction of relocated settlements. Our study is expected to improve the adaptation of relocation plans to future rural development.
Nudging Axially Compressed Cylindrical Panels Toward Imperfection Insensitivity
Authors: Cox B. S. , Groh R. M. J. , Pirrera A. 
Published: March 2019

Abstract
Curved shell structures are known for their excellent load-carrying capability and are commonly used in thin-walled constructions. Although theoretically able to withstand greater buckling loads than flat structures, shell structures are notoriously sensitive to imperfections owing to their postbuckling behavior often being governed by subcritical bifurcations. Thus, shell structures often buckle at significantly lower loads than those predicted numerically and the ensuing dynamic snap to another equilibrium can lead to permanent damage. Furthermore, the strong sensitivity to initial imperfections, as well as their stochastic nature, limits the predictive capability of current stability analyses. Our objective here is to convert the subcritical nature of the buckling event to a supercritical one, thereby improving the reliability of numerical predictions and mitigating the possibility of catastrophic failure. We explore the elastically nonlinear postbuckling response of axially compressed cylindrical panels using numerical continuation techniques. These analyses show that axially compressed panels exhibit a highly nonlinear and complex postbuckling behavior with many entangled postbuckled equilibrium curves. We unveil isolated regions of stable equilibria in otherwise unstable postbuckled regimes, which often possess greater load-carrying capacity. By modifying the initial geometry of the panel in a targeted—rather than stochastic—and imperceptible manner, the postbuckling behavior of these shells can be tailored without a significant increase in mass. These findings provide new insight into the buckling and postbuckling behavior of shell structures and opportunities for modifying and controlling their postbuckling response for enhanced efficiency and functionality.
The Effect of Manipulating Individual Consequences and Training Demands on Experiences of Pressure With Elite Disability Shooters
Authors: Stoker Mike , Maynard Ian , Butt Joanne , Hays Kate , Hughes Paul 
Published: March 2019

In previous research, multiple demands and consequences were manipulated simultaneously to examine methods for pressure training. Building on literature, in this study a single demand or consequence stressor was manipulated in isolation. Specifically, in a matched within-subject design, 6 international shooters (mean age 28.67 yr) performed a shooting task while exposed to a single demand (task, performer, environmental) or consequence (reward, forfeit, judgment) stressor. Perceived pressure, anxiety (intensity and direction), and performance were measured. Compared with baseline, manipulating demands did not affect pressure or anxiety. In contrast, pressure and cognitive anxiety significantly increased when judgment or forfeit consequence stressors were introduced. Thus, the findings lack support for manipulating demands but strongly support introducing consequences when pressure training. Compared with baseline, the judgment stressor also created debilitative anxiety. Hence, in terms of introducing a single stressor, judgment appeared most impactful and may be most effective for certain athlete populations.
Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses
Authors: Sun Yi-Qian , Burgess Stephen , Staley James R , Wood Angela M , Bell Steven , Kaptoge Stephen K , Guo Qi , Bolton Thomas R , Mason Amy M , Butterworth Adam S , Di Angelantonio Emanuele , Vie Gunnhild Å , Bjørngaard Johan H , Kinge Jonas Minet , Chen Yue , Mai Xiao-Mei 
Published: March 2019

Abstract

Editor’s Note
on Methodological Criticism and an Updated Analysis

Objective
To investigate the shape of the causal relation between body mass index (BMI) and mortality.

Design
Linear and non-linear mendelian randomisation analyses.

Setting
Nord-Trøndelag Health (HUNT) Study (Norway) and UK Biobank (United Kingdom).

Participants
Middle to early late aged participants of European descent: 56 150 from the HUNT Study and 366 385 from UK Biobank.

Main outcome measures
All cause and cause specific (cardiovascular, cancer, and non-cardiovascular non-cancer) mortality.

Results
12 015 and 10 344 participants died during a median of 18.5 and 7.0 years of follow-up in the HUNT Study and UK Biobank, respectively. Linear mendelian randomisation analyses indicated an overall positive association between genetically predicted BMI and the risk of all cause mortality. An increase of 1 unit in genetically predicted BMI led to a 5% (95% confidence interval 1% to 8%) higher risk of mortality in overweight participants (BMI 25.0-29.9) and a 9% (4% to 14%) higher risk of mortality in obese participants (BMI ≥30.0) but a 34% (16% to 48%) lower risk in underweight (BMI <18.5) and a 14% (−1% to 27%) lower risk in low normal weight participants (BMI 18.5-19.9). Non-linear mendelian randomisation indicated a J shaped relation between genetically predicted BMI and the risk of all cause mortality, with the lowest risk at a BMI of around 22-25 for the overall sample. Subgroup analyses by smoking status, however, suggested an always-increasing relation of BMI with mortality in never smokers and a J shaped relation in ever smokers.

Conclusions
The previously observed J shaped relation between BMI and risk of all cause mortality appears to have a causal basis, but subgroup analyses by smoking status revealed that the BMI-mortality relation is likely comprised of at least two distinct curves, rather than one J shaped relation. An increased risk of mortality for being underweight was only evident in ever smokers.
No such thing as bad publicity? A quantitative content analysis of print media representations of primary care out-of-hours services
Authors: Foster Hamish , Macdonald Sara , Patterson Chris , O’Donnell Catherine A 
Published: March 2019

ObjectiveTo explore how out-of-hours primary healthcare services (OOHS) are represented in UK national newspapers, focusing on content and tone of reporting and the use of personal narratives to frame stories.DesignA retrospective cross-sectional quantitative content analysis of articles published in 2005, 2010 and 2015.Data sourcesNexis database used to search 10 UK national newspapers covering quality, middle-market and tabloid publications.Inclusion/exclusion criteriaAll articles containing the terms ‘out-of-hours’ (≥3 mentions per article) or (‘NHS 24’ OR ‘NHS 111’ OR ‘NHS Direct’) AND ‘out-of-hours’ (≥1 mention per article) were included. Letters, duplicate news items, opinion pieces and articles without a substantial portion of the story (>50% of an article’s word count, as judged by researchers) concerning OOHS were excluded.Results332 newspaper articles were identified: 113 in 2005 (34.1%), 140 in 2010 (42.2%) and 79 in 2015 (23.8%). Of these, 195 (58.7%) were in quality newspapers, 99 (29.8%) in middle-market and 38 (11.3%) in tabloids. The most commonly reported themes were OOHS organisation, personal narratives and telephone triage. Stories about service-level crises and personal tragedy, including unsafe doctors and missed or delayed identification of rare conditions, predominated. The majority of articles (252, 75.9%) were negative in tone. This was observed for all included newspapers and by publication genre; middle-market newspapers had the highest percentage of negative articles (Pearson χ2=35.72, p<0.001). Articles presented little supporting contextual information, such as call rates per annum, or advice on how to access OOHS.ConclusionIn this first reported analysis of UK national newspaper coverage of OOHS, media representation is generally negative in tone, with frequent reports of ‘negative exemplars’ of OOHS crises and fatal individual patient cases with little or no contextualisation. We present recommendations for the future reporting of OOHS, which could apply to the reporting of healthcare services more generally.
Safety and survival data in patients with idiopathic pulmonary fibrosis treated with nintedanib: pooled data from six clinical trials
Authors: Lancaster Lisa , Crestani Bruno , Hernandez Paul , Inoue Yoshikazu , Wachtlin Daniel , Loaiza Lazaro , Quaresma Manuel , Stowasser Susanne , Richeldi Luca 
Published: March 2019

IntroductionNintedanib slows disease progression in patients with idiopathic pulmonary fibrosis (IPF) by reducing the rate of decline in forced vital capacity, with an adverse event profile that is manageable for most patients. We used data from six clinical trials to characterise the safety and tolerability profile of nintedanib and to investigate its effects on survival.MethodsData from patients treated with ≥1 dose of nintedanib 150 mg two times per day or placebo in the 52-week TOMORROW trial and/or its open-label extension; the two 52-week INPULSIS trials and/or their open-label extension, INPULSIS-ON; and a Phase IIIb trial with a placebo-controlled period of ≥6 months followed by open-label nintedanib were pooled. All adverse events, irrespective of causality, were included in descriptive analyses. Parametric survival distributions were fit to pooled Kaplan-Meier survival data from the trials and extrapolated to estimate long-term survival.ResultsThere were 1126 patients in the pooled nintedanib group and 565 patients in the pooled placebo group. The mean duration of nintedanib treatment was 28 months. No new safety signals were observed. Incidence rates of bleeding, liver enzyme elevations and cardiovascular events were consistent with those observed in the INPULSIS trials. Diarrhoea was reported at a lower event rate in the pooled nintedanib group than in nintedanib-treated patients in the INPULSIS trials (76.5 vs 112.6 events per 100 patient exposure-years) and infrequently led to permanent treatment discontinuation (3.6 events per 100 patient exposure-years). Based on the Weibull distribution, mean (95% CI) survival was estimated as 11.6 (9.6, 14.1) years in nintedanib-treated patients and 3.7 (2.5, 5.4) years in placebo-treated patients.ConclusionsBased on pooled data from six clinical trials, the adverse event profile of nintedanib was manageable for most patients. Exploratory analyses based on extrapolation of survival data suggest that nintedanib extends life expectancy in patients with IPF.
Fractional flow reserve derived from microcatheters versus standard pressure wires: a stenosis-level meta-analysis
Authors: Seligman Henry , Shun-Shin Matthew J , Vasireddy Anushkumar , Cook Christopher , Ahmad Yousif Y , Howard James , Sen Sayan , Al-Lamee Rasha , Nijjer Sukhjinder , Chamie Daniel , Davies Justin , Mayet Jamil , Francis Darrel P , Petraco Ricardo 
Published: March 2019

AimsTo determine the agreement between sensor-tipped microcatheter (MC) and pressure wire (PW)-derived fractional flow reserve (FFR).Methods and resultsStudies comparing FFR obtained from MC (FFRMC, Navvus Microcatheter System, ACIST Medical Systems, Eden Prairie, Minnesota, USA) versus standard PW (FFRPW) were identified, and a meta-analysis of numerical and categorical agreement was performed. The relative levels of drift and device failure of MC and PW systems from each study were assessed. Six studies with 440 lesions (413 patients) were included. The mean overall bias between FFRMCand FFRPWwas −0.029 (FFRMClower). Bias and variance were greater for lesions with lower FFRPW(p<0.001). Using a cut-off of 0.80, 18 % of lesions were reclassified by FFRMCversus FFRPW(with 15 % being false positives). The difference in reported drift between FFRPWand FFRMCwas small. Device failure was more common with MC than PW (7.1% vs 2%).ConclusionFFRMCsystematically overestimates lesion severity, with increased bias in more severe lesions. Using FFRMCchanges revascularisation guidance in approximately one out of every five cases. PW drift was similar between systems. Device failure was higher with MC.
Pacing therapy in the management of unexplained syncope: a tertiary care centre prospective study
Authors: Yasa Ekrem , Ricci Fabrizio , Holm Hannes , Persson Torbjörn , Melander Olle , Sutton Richard , Hamrefors Viktor , Fedorowski Artur 
Published: March 2019

ObjectivePacemaker (PM) therapy is effective when syncope is associated with bradycardia, but syncope recurrences and fall injuries after PM implantation may occur. We aimed to survey indications and outcomes of PM implantation, following evaluation of unexplained syncope.MethodsAmong 1666 consecutive unpaced patients investigated in a tertiary syncope unit by carotid-sinus massage (CSM), head-up tilt test (HUT) and ECG monitoring, 106 (6.4%; age, 65 ± 17 years) received a PM. We assessed bradycardia detection methods, PM implantation indications, and explored incidence of recurrent syncope, fall-related fractures and mortality.ResultsIndications for PM therapy were met in 32/106 patients (30%) by CSM, in 41/106 (39%) by HUT, in 14/106 patients (13%) by implantable loop-recorder (ILR) and in 19/106 (18%) by standard ECG. Sinus arrest with asystole was the predominant PM indication during CSM/HUT and external ECG monitoring, whereas ILR detected proportionally the same numbers o f asystole due to sinus arrest and atrioventricular block. During follow-up (median, 4.3 years), 15 patients (14%) had syncope recurrence, 15 suffered fall-related fractures and 9 died. Neither syncope recurrence nor fall-related fractures were dependent on initial PM indication. The composite endpoint of recurrent syncope/fall-related fracture was associated with treated hypertension (OR 2.45; 95% CI 1.00 to 6.0), reduced glomerular filtration rate (OR 1.63 per 10 mL/min↓; 95% CI 1.22 to 2.19) and atrial fibrillation (OR 3.98; 95% CI 1.11 to 14.3). Recurrent syncope predicted increased mortality (OR 9.20; 95% CI 1.89 to 44.8).ConclusionsCardiovascular autonomic testing and ECG monitoring effectively identify pacing indications in patients with unexplained syncope. After PM implantation, treated hypertension, renal failure and atrial fibrillation predict syncope recurrence and fall-related injury. Recurrent syncope predicts increased mortality.
Inflation from the internal volume in type IIB/F-theory compactification
Authors: Antoniadis Ignatios , Chen Yifan , Leontaris George K. 
Published: March 2019

We study the cosmological inflation within a recently proposed framework of perturbative moduli stabilization in type IIB/F-theory compactifications on Calabi–Yau threefolds. The stabilization mechanism utilizes three stacks of magnetized 7-branes and relies on perturbative corrections to the Kähler potential that grow logarithmically in the transverse sizes of co-dimension two due to local tadpoles of closed string states in the bulk. The inflaton is the Kähler modulus associated with the internal compactification volume that starts rolling down the scalar potential from an initial condition around its maximum. Although the parameter space allows moduli stabilization in de Sitter space, the resulting number of e-foldings is too low. An extra uplifting source of the vacuum energy is then required to achieve phenomenologically viable inflation and a positive (although tiny) vacuum energy at the minimum. We discuss a class of uplifting potentials arising from strongly coupled matter fields. In a particular case, they reproduce the effect of the new Fayet–Iliopoulos term recently discussed in a supergravity context, that can be written for a non-R-symmetry U(1) and is gauge invariant at the Lagrangian level.
Ca Silicide Films on Si(1 0 0) and Si(1 1 1) Substrates: Structure, Optical and Electrical Properties
Authors: Galkin N. G. , Galkin K. N. , Tupkalo A. V. , Dotsenko S. A. , Fogarassi Z. , Pecz B. 
Published: March 2019

The crystal structure, optical and electrical properties of Ca silicide films grown by MBE and RDE processes on Si(1 0 0) and Si(1 1 1) substrates have been compared. Optical spectroscopy studies, including Raman spectroscopy, have shown two silicide phases: CaSi2 and CaSi. The RDE-grown film on Si(1 1 1) substrate with the CaSi2 phase is characterized by higher transparency than MBE-grown films. Therefore, the CaSi2 RDE-grown phase is found to be predominant and has a lower absorption in the IR region of the spectrum. After 1.5-year storage of Ca silicide film oxidation, partial destruction of the CaSi2 phase and conservation of the CaSi layer were revealed by TEM and HRTEM analyses. The complex behavior of magnetoresistance versus magnetic induction, including positive and negative curves, has been found for the MBE-grown films in the temperature range of 1.3–300[Formula: see text]K. The RDE-grown CaSi2 film has displayed a semiconducting type of the magnetoresistance.
Anisotropic Temperature-Dependent Interaction of Ferromagnetic Nanoparticles Embedded Inside CNT
Authors: Prischepa S. , Danilyuk A. 
Published: March 2019

We analyze the magnetization versus magnetic field curves of Fe-based nanoparticles embedded inside CNT. Measurements were performed at different temperatures and orientations of the magnetic field. We demonstrate that, for the parallel field the magnetic anisotropy dominates and the coherent anisotropy is of great importance at low temperatures. At high temperatures, the exchange coupling becomes stronger, but the coherent anisotropy still occurs. For the perpendicular field, the coherence anisotropy is absent, and the dimensionality of the system reduces to 2D. The results are discussed in the framework of the correlation functions of the magnetic anisotropy axes.
Long Noncoding RNA MALAT1 Regulates Cancer Glucose Metabolism by Enhancing mTOR-Mediated Translation of TCF7L2
Authors: Malakar Pushkar , Stein Ilan , Saragovi Amijai , Winkler Roni , Stern-Ginossar Noam , Berger Michael , Pikarsky Eli , Karni Rotem 
Published: March 2019

Abstract

Reprogrammed glucose metabolism of enhanced aerobic glycolysis (or the Warburg effect) is known as a hallmark of cancer. The roles of long noncoding RNAs (lncRNA) in regulating cancer metabolism at the level of both glycolysis and gluconeogenesis are mostly unknown. We previously showed that lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) acts as a proto-oncogene in hepatocellular carcinoma (HCC). Here, we investigated the role of MALAT1 in regulating cancer glucose metabolism. MALAT1 upregulated the expression of glycolytic genes and downregulated gluconeogenic enzymes by enhancing the translation of the metabolic transcription factor TCF7L2. MALAT1-enhanced TCF7L2 translation was mediated by upregulation of SRSF1 and activation of the mTORC1–4EBP1 axis. Pharmacological or genetic inhibition of mTOR and Raptor or expression of a hypophosphorylated mutant version of eIF4E-binding protein (4EBP1) resulted in decreased expression of TCF7L2. MALAT1 expression regulated TCF7L2 mRNA association with heavy polysomes, probably through the TCF7L2 5′-untranslated region (UTR), as determined by polysome fractionation and 5′UTR-reporter assays. Knockdown of TCF7L2 in MALAT1-overexpressing cells and HCC cell lines affected their metabolism and abolished their tumorigenic potential, suggesting that the effects of MALAT1 on glucose metabolism are essential for its oncogenic activity. Taken together, our findings suggest that MALAT1 contributes to HCC development and tumor progression by reprogramming tumor glucose metabolism.

Significance:
These findings show that lncRNA MALAT1 contributes to HCC development by regulating cancer glucose metabolism, enhancing glycolysis, and inhibiting gluconeogenesis via elevated translation of the transcription factor TCF7L2.