bluuebunny/crossref_metadata_2025_split huggingface dataset:
The seasonality of nonpolio enteroviruses in the United States: Patterns and drivers
Authors: Pons-Salort Margarita , Oberste M. Steven , Pallansch Mark A. , Abedi Glen R. , Takahashi Saki , Grenfell Bryan T. , Grassly Nicholas C. 
Published: March 2018

Significance
Nonpolio enteroviruses are responsible for a high burden of neurological and other diseases and exhibit a peak in summer every year, but drivers of their seasonality are not clearly understood. We find that the seasonal pattern of enterovirus cases in the United States has a spatial structure comparable with that of prevaccination poliomyelitis. The average monthly distribution of cases is more flat in the south and has a more pronounced peak that occurs later toward the north, with the peak for poliomyelitis occurring approximately 1 month later than that for nonpolio enteroviruses. We find that climate, but not demography, is likely to explain this seasonality and identify the dew point temperature as a strong predictor of the intensity of enterovirus transmission.
Category change in the English gerund
Authors: Fonteyn Lauren , Heyvaert Liesbet 
Published: March 2018

Abstract
This study considers the diachronic categorial shift from nominal (NG) to verbal gerunds (VG) in Middle English in terms of Langacker’s functional account of noun phrases and clauses as ‘deictic expressions’. The analysis shows that the Middle English gerund was essentially formally nominal but functionally hybrid, thus exhibiting ‘form-function friction’. This friction furthered a split in the gerundive system between a verbal component associated with clausal deixis, alongside a nominal component, which specialized in nominal deixis; but this split is not absolute. The constructionist idea of language as a network of (inter)paradigmatically connected constructions helps to explain why the verbal gerund seems to simultaneously drift away from and again partake in the deictic behaviour of the nominal category.
Category change in construction morphology
Authors: Booij Geert , Audring Jenny 
Published: March 2018

Abstract
Morphological constructions can be formalized as schemas that specify semantic and formal output properties of complex words. Such schemas impose these output properties on their constituent words through various coercion mechanisms. In this article we focus on coercion-by-override and the concomitant category change. Our data are mainly from Dutch.
The meaning of a syntactic or morphological construction can override the lexical meaning of a word in that construction. Morphological schemas may therefore change the semantic class of the base word. Semantic coercion may be accompanied by changes in word class.
Morphological schemas may receive a higher degree of productivity within certain syntactic constructions, a phenomenon known as embedded productivity. Thus, morphological schemas contribute to the creativity and flexibility of the language system.
The exponential rise of induced seismicity with increasing stress levels in the Groningen gas field and its implications for controlling seismic risk
Authors: Bourne S J , Oates S J , van Elk J 
Published: March 2018

SUMMARYInduced seismicity typically arises from the progressive activation of recently inactive geological faults by anthropogenic activity. Faults are mechanically and geometrically heterogeneous, so their extremes of stress and strength govern the initial evolution of induced seismicity. We derive a statistical model of Coulomb stress failures and associated aftershocks within the tail of the distribution of fault stress and strength variations to show initial induced seismicity rates will increase as an exponential function of induced stress. Our model provides operational forecasts consistent with the observed space–time–magnitude distribution of earthquakes induced by gas production from the Groningen field in the Netherlands. These probabilistic forecasts also match the observed changes in seismicity following a significant and sustained decrease in gas production rates designed to reduce seismic hazard and risk. This forecast capability allows reliable assessment of alternative control options to better inform future induced seismic risk management decisions.
CoPhosK: A Method for Comprehensive Kinase Substrate Annotation Using Co-phosphorylation Analysis
Authors: Ayati Marzieh , Wiredja Danica , Schlatzer Daniela , Maxwell Sean , Li Ming , Koyutürk Mehmet , Chance Mark R. 
Published: March 2018

AbstractWe present CoPhosK to predict kinase-substrate associations for phosphopeptide substrates detected by mass spectrometry (MS). The tool utilizes a Naïve Bayes framework with priors of known kinase-substrate associations (KSAs) to generate its predictions. Through the mining of MS data for the collective dynamic signatures of the kinases’ substrates revealed by correlation analysis of phosphopeptide intensity data, the tool infers KSAs in the data for the considerable body of substrates lacking such annotations. We benchmarked the tool against existing approaches for predicting KSAs that rely on static information (e.g. sequences, structures and interactions) using publically available MS data, including breast, colon, and ovarian cancer models. The benchmarking reveals that co-phosphorylation analysis can significantly improve prediction performance when static information is available (about 35% of sites) while providing reliable predictions for the remainder, thus tripling the KSAs available from the experimental MS data providing a to comprehensive and reliable characterization of the landscape of kinase-substrate interactions well beyond current limitations.Author SummaryKinases play an important role in cellular regulation and have emerged as an important class of drug targets for many diseases, particularly cancers. Comprehensive identification of the links between kinases and their substrates enhances our ability to understand the underlying mechanism of diseases and signalling networks to drive drug discovery. Most of the current computational methods for prediction of kinase-substrate associations use static information such as sequence motifs and physical interactions to generate predictions. However, phosphorylation is a dynamic process and these static predictions may overlook unique features of cellular context, where kinases may be rewired. In this manuscript, we propose a computational method, CoPhosK, which uses the mass spectrometry based phosphoproteomics data to predict the kinase for all identified phosphosites in the experiment. We show that our approach complements and extends existing approaches.
Modulation of the mTOR pathway in male Lewis rats after morphine self-administration and subsequent extinction training
Authors: Ucha Marcos , Coria Santiago M , Núñez Adrián E , Santos-Toscano Raquel , Roura-Martínez David , Fernández Ruiz Javier , Higuera-Matas Alejandro , Ambrosio Emilio 
Published: March 2018

AbstractAddiction is a chronic disorder with an elevated risk of relapse, even after long periods of abstinence. Some of the neural mechanisms mediating addictions require protein synthesis, which could be relevant for the development of more effective treatments. The mTOR signaling pathway regulates protein synthesis processes that have recently been linked to the development of drug addiction. Thus, we have assessed the effects of morphine self-administration and its subsequent extinction on the expression of several genes that act in this pathway, and on the levels of some phosphoproteins in three brain areas related to reward learning and extinction: the amygdala, the nucleus accumbens, and the prefrontal cortex. We found an increase inRaptorandEif4ebp2gene expression in the amygdala of rats that self-administered morphine, and this persisted beyond the extinction period. The expression ofInsrin the amygdala of control animals decreased over time while the opposite effect was seen in the rats that self-administered morphine. We also found a strong correlation between some of the biochemical variables measured and behavioral traits, suggesting a significant role for the genes and phosphoproteins identified, mostly in the amygdala, in the behavioral effects of morphine.
Development of carbon anode for cathodic protection of mild steel in chloride environment
Authors: Osundare Ayomide , Oloruntoba Daniel Toyin , Popoola Patricia 
Published: March 2018

Purpose
The purpose of this paper is to develop technically efficient and economically effective sacrificial anodes that can be used for cathodic protection (CP) of pipelines in marine environment and fill the knowledge gap in the use of carbon anodes for CP.

Design/methodology/approach
A sacrificial anode was produced via sand casting by adding varying weight-percent of coal and ferrosilicon to a constant weight-percent of grey cast iron. The hardness of the produced anodes was evaluated using a Rockwell hardness tester. The microstructure of the anodes was observed with scanning electron microscope/energy-dispersive spectroscopy (SEM/EDS). X-ray diffraction (XRD) was used to study the phases present. A potentiostat was used to assess the corrosion behaviour of the produced anodes and mild steel in 3.5 Wt.% NaCl solution.

Findings
The SEM results showed that some anodes had interdendritic graphite formation, while others had pronounced graphite flakes. The EDS analysis showed carbon and iron to be the prominent elements in the anode. Anodes Bc, B2 and B5 with a corrosion rate of two order of magnitudes were observed to have similar dendritic structures. Anode B4 is the most electronegative with an Ecorr of −670.274 mV Ag/AgCl and a corrosion rate of 0.052475 mmpy. The produced anodes can be used to protect mild steel in the same environment owing to their lower Ecorr values compared to that of mild steel −540.907 mV Ag/AgCl.

Originality/value
Alloying has been majorly used to improve the efficiency of sacrificial anodes and to alleviate its setbacks. However, development of more technically efficient and economically effective sacrificial anodes via production of composite has not been exhaustively considered. Hence, this research focuses on the development of a carbon based anode by adding natural occurring coal and ferrosilicon to grey cast iron. The corrosion behaviour of the produced anode was evaluated and compared to that of mild steel in marine environment.
The current farm downturn vs the 1920s and 1980s farm crises
Authors: Zhang Wendong , Tidgren Kristine 
Published: March 2018

Purpose
The purpose of this paper is to examine the current farm economic downturn and credit restructuring by comparing it with the 1920s and 1980s farm crises from both economic and regulatory perspectives.

Design/methodology/approach
This paper closely compares critical economic and regulatory aspects of the current farm downturn with two previous farm crises in the 1920s and 1980s, and equally importantly, the golden eras that occurred before them. This study compares key aggregate statistics in land value, agricultural credit, lending regulations, and also evaluates the situations and impacts on individual farmer households by using three representative case studies.

Findings
The authors argue that there are at least three economic and regulatory reasons why the current farm downturn is unlikely to slide into a sudden collapse of the agricultural markets: strong, real income; growth in the 2000s, historically low interest rates; and more prudent agricultural lending practices. The current farm downturn is more likely a liquidity and working capital problem, as opposed to a solvency and balance sheet problem for the overall agricultural sector. The authors argue that the trajectory of the current farm downturn will likely be a gradual, drawn-out one like that of the 1920s farm crisis, as opposed to a sudden collapse as in the 1980s farm crisis.

Originality/value
The review provides empirical evidence for cautious optimism of the future trajectory of the current downturn, and argues that the current downturn is much more similar to the 1920s pattern than the 1980s crisis.
An integrated approach for implementation of agile manufacturing system in an Indian manufacturing industry
Authors: Sindhwani Rahul , Malhotra Vasdev 
Published: March 2018

Purpose
The advent of globalization not only made the manufacturing sector highly competitive but also facilitated best-quality products. The trend is further augmented by e-Commerce which increases the penetration to the targeted customer with the easy availability of customized product. In this backdrop, Indian manufacturing industries are striving hard to seek out best systems which will yield maximum profitability. Time is ripe to realize the true potential of agile manufacturing system (AMS). Infusion of AMS in manufacturing industry will bring forth the elusive mix of customer needs and products at lowest possible cost. But adoption and implementation of AMS is a challenging task in itself. There are certain facilitators and criteria which not only facilitate the system but also help in the effective and smooth implementation of this system. The purpose of this paper is to identify the criteria to weightage and ranking to AMS facilitators. This study was carried out by different approaches, namely, entropy approach, multi-objective optimization on the basis of ratio analysis (MOORA) method, Vlsekriterijumska Optimizacija I Kompromisno Resenje (VIKOR) analysis and a cross-sectional survey of manufacturing firms in India.

Design/methodology/approach
The criteria and facilitators are identified followed by the application of entropy approach, MOORA method and VIKOR analysis to study and analyze the criteria weight and provide the ranking to AMS facilitators.

Findings
The result of the entropy approach concludes that beneficiary and non-beneficiary criteria carry 48.43 and 51.56 percent weight, respectively. MOORA method and VIKOR analysis conclude that organization structure and virtual enterprise facilitators are carrying the first and second rank, respectively.

Research limitations/implications
This study is completed on the basis of responses from few experts from industry and academicians who may not reflect the attitude of entire industry community.

Practical implications
This research is expected to facilitate policy makers in government and industries to frame policies for optimum utilization of resources and infrastructure for better performance. This paper helps the researcher to do a case study on the implementation of AMS and then finally helps to society in getting the high-quality product in an easy way.

Originality/value
Integration of entropy approach, MOORA method and VIKOR analysis with identification of AMS criteria weightage and ranking to AMS facilitators has been recommended for an industry which is an innovative effort for the execution of AMS.
Model for assessing the quality of marketing-management education
Authors: Rivera Jaime , Alarcón Víctor 
Published: March 2018

PurposeThis study aims to propose and test a model of educational quality in marketing-management by incorporating resource-capability variables that are linked to learning outcomes for students and the competitive positioning of universities.Design/methodology/approachDrawing on the resource-dependence theory, this study develops a comprehensive model for measuring educational quality. A sample comprising Spanish university teachers has been used to test the hypothesised relationships by using a two-stage least squares regression analysis while controlling for the possible effect of the public/private nature of the university.FindingsThe results validate the model and show that educational capabilities are reliable variables for predicting the educational quality of marketing-management programmes at Spanish universities.Research limitations/implicationsSimilar to all educational research studies, certain problems have been acknowledged with respect to the data and the theoretical constructs that are used in the study. Future studies can replicate this study’s model by using more direct objective measures of the theoretical constructs and extend the study to other countries with different educational contexts.Practical implicationsThe results provide guidance to marketing teachers at a university in designing high-quality marketing-management educational programmes and in developing self-diagnostic tools that can determine a university’s likelihood of competitive success.Originality/valueThis study is one of the few studies to apply the resource-dependence theory to the analysis of the variables associated with the quality of marketing-management education. In doing so, the study presents original multiitem scales to improve the measurement of model constructs.
Tourism and male homosexual identities: directions for sociocultural research
Authors: Monterrubio Carlos 
Published: March 2018

Purpose
This paper aims to offer a critical review of the existing research on the relationships between tourism and male homosexual identities and, based on a sociocultural perspective, suggestions for specific directions in future research.

Design/methodology/approach
The analysis is based on a review of the literature that focuses on two independent yet intersecting topics: tourism and homosexuality and identity formation processes.

Findings
Specific directions for future research are offered regarding the role that tourism plays in homosexual identity development. The proposed paths for future research include the tangible contributions of tourism to the stages of homosexual tourists’ identity development and the (re)construction, negotiation and globalisation of homosexual and queer identities through tourists’ cultural interactions. Two further suggested directions are the significance of tourism for non-Western homosexual tourists and tourism’s impacts on local homosexual identities.

Research limitations/implications
This study is based solely on the existing literature on male homosexuality and mostly on studies published in English.

Originality/value
The research included a critical analysis of the commonly assumed significance of tourism in homosexual identity formation. The results provide directions for future empirical research and calls for a solid theoretical foundation that allows researchers to demonstrate, understand and explain how tourism contributes to gay and queer identities.
The immune characterization of interferon‐β responses in tuberculosis patients
Authors: Zhang Xiao , Sun Yi , He Caiyun , Qiu Xiaofen , Zhou Dalei , Ye Zulu , Long Yakang , Tang Tao , Su Xuan , Ma Jiangjun 
Published: March 2018

ABSTRACTWe aimed to assess the immunoregulatory effects of IFN‐β in patients with tuberculous pleurisy. IFN‐β, IFN‐γ and IL‐17 expression levels were detected, and correlations among these factors in different culture groups were analyzed. Pleural fluid mononuclear cells (PFMC) from tuberculous pleural effusions, but not peripheral blood mononuclear cells (PBMC) from healthy donors, spontaneously expressed IFN‐β, IL‐17 and IFN‐γ. Moreover, exogenous IFN‐β significantly inhibited the expression of IL‐17 in PFMC. By contrast, IFN‐β simultaneously enhanced the levels of IFN‐γ. To further investigate the regulation of IL‐17 and IFN‐γ by endogenous IFN‐β, an IFN‐β neutralizing antibody was simultaneously added to bacillus Calmette‐Guérin (BCG)‐stimulated PFMC. IL‐17 expression was significantly increased, but IFN‐γ production was markedly decreased in the experimental group supplemented with the IFN‐β neutralizing antibody. Simultaneously, IL‐17 production was remarkably increased in the experimental group supplemented with the IFN‐γ neutralizing antibody. Taken together, in our study, we first found that freshly isolated PFMC, but not PBMC from healthy donors, spontaneously expressed IFN‐β, IL‐17 and IFN‐γ in vivo. Moreover, IFN‐β suppressed IL‐17 expression and increased IFN‐γ production. Furthermore, both IFN‐β and IFN‐γ down‐regulated IL‐17 expression. These observations suggest that caution is required when basing anti‐tuberculosis treatment on the inhibition of IFN‐β signaling.
Patient‐controlled hospital admission for patients with severe mental disorders: a nationwide prospective multicentre study
Authors: Thomsen C. T. , Benros M. E. , Maltesen T. , Hastrup L. H. , Andersen P. K. , Giacco D. , Nordentoft M. 
Published: March 2018

ObjectiveTo assess whether implementing patient‐controlled admission (PCA) can reduce coercion and improve other clinical outcomes for psychiatric in‐patients.MethodsDuring 2013–2016, 422 patients in the PCA group were propensity score matched 1:5 with a control group (n = 2110) that received treatment as usual (TAU). Patients were followed up for at least one year using the intention to treat principle utilising nationwide registers. In a paired design, the outcomes of PCA patients during the year after signing a contract were compared with the year before.ResultsNo reduction in coercion (risk difference = 0.001; 95% CI: −0.038; 0.040) or self‐harming behaviour (risk difference = 0.005; 95% CI: −0.008; 0.018) was observed in the PCA group compared with the TAU group. The PCA group had more in‐patient bed days (mean difference = 28.4; 95% CI: 21.3; 35.5) and more medication use (P < 0.0001) than the TAU group. Before and after analyses showed reduction in coercion (P = 0.0001) and in‐patient bed days (P = 0.0003).ConclusionImplementing PCA did not reduce coercion, service use or self‐harm behaviour when compared with TAU. Beneficial effects of PCA were observed only in the before and after PCA comparisons. Further research should investigate whether PCA affects other outcomes to better establish its clinical value.
Seasonality overrides differences in butterfly species composition between natural and anthropogenic forest habitats
Authors: Habel J. C. , Seibold S. , Ulrich W. , Schmitt T. 
Published: March 2018

AbstractAnthropogenic disturbances that alter habitat structures can lead to strong changes in species composition. The importance of certain habitat features for structuring species composition, however, may be determined by the availability of resources that can seasonally fluctuate. The Kenyan Arabuko Sokoke coastal forest consists of three pristine forest types and provides various anthropogenic forest‐like habitats, such as plantations and transition zones between forest and agricultural land. In parallel, this region experiences pronounced climatic seasonality which causes differences in resource availability. To test for potential differences in butterfly communities between natural and anthropogenic forest habitats, and whether they vary seasonally, we assessed butterfly species along transects in all five habitat types during the rainy and the consecutive dry season. We compiled ecological characteristics for each transect and for each butterfly species. We found highest species richness and abundances in the three natural forest habitats during the rainy season. Our data show distinct species clusters for each habitat type during the rainy season. In contrast, butterfly species composition does not form distinct community groups during the dry season. During this time period, highest species richness and abundances are found in plantations. These temporal differences in species richness, abundance and species composition between the two seasons are assumed to be driven by limited nectar availability inside of the forest during the dry season. This situation might lead to increased mobility and the invasion of anthropogenic habitats, where nectar sources are still available during the dry season. Thus, plantations might represent a surrogate habitat for forest butterflies during their imaginal stage, but do not represent a suitable habitat providing all resources needed for successful larval development.