bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is open strategy a good fit for Public‐Private hybrid organizations?
Authors: Rosser Christian , Ilgenstein Sabrina A. , Jacobs Claus D. 
Published: November 2024

AbstractThis paper investigates whether the systematic application of open strategy can align goals in emerging public‐private hybrid organizations, which face the challenge of integrating different identities, forms, and rationales from both public and private stakeholders. We develop an evaluative framework, addressing three crucial issues for a public‐private hybrid's early development: What is the public‐private hybrid's purpose? Who are the strategic actors involved? What knowledge and skills are needed? By applying the framework to a qualitative case study from the field of Swiss innovation policy, we learn that inclusiveness and transparency largely depend on the timeline of a hybrid's emergence. Public‐private hybrids can either choose an inclusive, transparent but gradual, and slow strategy process or a speedy process characterized by the traditional ‘management at the top’ approach. This study offers both empirical and theoretical insights into strategy development in public‐private hybrid organizations and its significance for public policy implementation.
Research on the construction of novel nano‐modified clean fracturing fluid and the migration characteristics of proppants
Authors: Liu Yanwei , Jia Zichao , Zuo Weiqin , Han Hongkai , Xie Kunrong , Li Liwen 
Published: November 2024

AbstractClean fracturing fluid exhibits desirable characteristics, such as low residue, easy flowback, minimal reservoir damage, and favorable rheology, making it highly adaptable. However, challenges remain in terms of high cost, large consumption, and poor stability. Hence, this study focuses on incorporating SiO2 nanoparticles into clean fracturing fluid to develop a novel nano‐modified system. Experimental tests were conducted to analyze the impact of mass fractions of hexadecyltrimethylammonium chloride (CTAC), sodium salicylate (Nasal), and SiO2 nanoparticles on the viscosity of the solution. The results indicate a significant increase in viscosity with higher mass fractions of SiO2. A nano‐modified clean fracturing fluid composition of 1.5 wt% CTAC, 0.4 wt% Nasal, and 0.1 wt% SiO2 was selected as it meets the technical specifications for fracturing fluid while exhibiting excellent elastic modulus (2.279 Pa) and viscous modulus (0.818 Pa), thereby displaying superior viscoelastic properties. Furthermore, the system maintains a viscosity above 20 mPa.s under temperature (70°C) and shear stress (170 s−1), indicating robust temperature and shear resistance to meet the demands of downhole fracturing and proppant transport. Based on rheological experimental data, a Carreau rheological model was established for the nano‐modified clean fracturing fluid. Considering particle interaction, wall blockage, and fluid filtration, a settlement model was modified with a correction coefficient, leading to the construction of a mathematical model for correcting proppant particle settling in fractures. The error between measured settlement velocity and calculated values remained within 10%. Finally, the migration law of proppant is studied, and the settlement law of proppant in fracturing fluid and fracture is clarified.
The V‐Shaped Structuring Regulated via the LuxS‐Dependent Quorum‐Sensing Pathway Is Associated With Lactiplantibacillus plantarum Survivability in Acidic Environments
Authors: Venugopal Athira , Sionov Ronit Vogt , Kroupitski Yulia , Steinberg Doron , Shemesh Moshe 
Published: November 2024

ABSTRACTTolerance to acidic environments is an important adaptive feature of the probiotic bacterium Lactiplantibacillus plantarum for surviving gastrointestinal transit or food processing. Here, we report a previously uncharacterized biological process that enables a highly coordinated adaptation of this bacterium to acidic stress. We provide mechanistic evidence for the role of the V‐shaped multicellular structuring, associated with incomplete daughter cell separation, in the survival of L. plantarum cells in acidic environments. We also show that this process facilitates structured biofilm formation through the LuxS‐dependent quorum‐sensing pathway associated with autoinducer‐2 (AI‐2) production. The LuxS knockout results in compromised V‐shaped structuring and poor biofilm formation under acidic conditions, whereas exogenous supplementation of 4,5‐dihydroxy‐pentanedione (DPD), the precursor of AI‐2, to the LuxS knockout strain, restores V‐shaped structuring and biofilm formation in an acidic environment. Furthermore, we show that LuxS‐dependent V‐shaped structuring provides an extraordinary protection mode for cellular survivability in extremely acidic conditions. Consequently, we propose that the self‐generated V‐shaped structuring, regulated by LuxS, is associated with protective and coordinated multicellular behavior during adaptation to acidic stress. It is believed that this study paves the way for developing a promising platform for preserving and delivering probiotic cells to mammalian hosts by utilizing persistent geometrical structuring.
Evaluation of HPLC Profile, Antioxidant, Quorum Sensing, Biofilm, Swarming Motility, and Enzyme Inhibition Activities of Conventional and Green Extracts of Salvia triloba
Authors: Quradha Mohammed Mansour , Tamfu Alfred Ngenge , Duru Mehmet Emin , Kucukaydin Selcuk , Iqbal Mudassar , Qahtan Abdulkader Moqbel Farhan , Khan Rasool , Ceylan Ozgur 
Published: November 2024

ABSTRACTThe current study aims to prepare a green extract using a new method in addition to conventional extraction methods including; methanolic and ultrasonic extraction of Salvia triloba, to compare their phenolic composition utilizing high‐performance liquid chromatograph equipped with a diode array detector (HPLC‐DAD), anti‐bacterial, anti‐oxidant, and enzyme inhibition activities. The results of HPLC‐DAD analysis showed that Rosmarinic acid was found the highest amount in the methanolic extract followed by ultrasonic and green extracts as 169.7 ± 0.51, 135.1 ± 0.40, and 28.58 ± 0.46 μg/g respectively. The Trans‐cinnamic acid (4.40 ± 0.09 μg/g) was found exclusively in ultrasonic extract. For bioactivities, the green extract exhibited the highest biofilm inhibition against Enterococcus faecalis compared to other extracts, while the methanolic extract outperformed both ultrasonic‐assisted and green extract against Staphylococcus aureus and Escherichia coli strains at minimum inhibitory concentration. The methanolic and green extract exhibited considerable quorum sensing inhibition against Chromobacterium violaceum CV026, while no activity was recorded from ultrasonic‐assisted extract. The methanolic and ultrasonic‐assisted extracts of S. triloba recorded moderate butyrylcholinesterase inhibition; each extract demonstrated limited inhibitory effects on the urease enzyme. Similarly, each extract of S. triloba demonstrated significant antioxidant activity, with the highest activity exhibited by methanolic extract as β‐carotene‐linoleic acid assay (IC50 = 10.29 ± 0.36 μg/mL), DPPH• assay (IC50 = 27.77 ± 0.55 μg/mL), ABTS•+ assay (IC50 = 15.49 ± 0.95 μg/mL), metal chelating assay (IC50 = 57.80 ± 0.95 μg/mL), and CUPRAC (assay A0.50 = 32.54 ± 0.84 μg/mL). Furthermore, the methanolic extract exhibited antioxidant activity better than α‐tocopherol (Standard used). The current study demonstrated the potential of green solvent(s) as eco‐friendly alternative for extractin phenolic compounds from S. triloba and evaluated their biological activities for the first time.
Cocktail Sausage Supplemented With Whole Tomato Powder Encapsulated in Chia Seed Mucilage (Salvia hispanica L.) by Lypholization: The Color, Sensory, Textural Properties, and Oxidation Stability of Sausage
Authors: Sekhavatizadeh Seyed Saeed , Faryabi Fatemeh , Ganje Mohammad 
Published: November 2024

ABSTRACTThe deterioration of meat products is significantly influenced by the oxidation of lipids. The addition of antioxidants is one of the accepted methods to retard lipid oxidation. The goal of this research was to encapsulate tomato powder with chia seed mucilage by lyophilization. Tomato powder and chia seed mucilage were used as the wall material at three ratios 1:1 (T1:C1), 2:1 (T2:C1), and 1:2 (T1:C2). The particle size, encapsulation efficiency, rheology, and solubility index of the beads were assessed. Three sausage samples, including the control, 3% w/w tomato powder (TPsample), and 6% w/w bead (EnTPsample), were produced. The color, texture, peroxide, thiobarbituric acid, and sensory parameters of the sausage were analyzed during storage. The results showed that T2:C1 had a maximum encapsulation efficiency (44.71%) with particle size (172.31 nm). T1:C1 had a highly significant value in the solubility index (90.09% w/w), but for the viscosity parameter, T1:C2 had a maximum value among the samples. FTIR and X‐ray diffraction analyses demonstrated successful encapsulation in all samples. The water holding capacity (6.92% w/w), hardness (2992.5 g), and gumminess (2772.3 g) were the highest, but cooking loose (10.98% w/w) the lowest in the EnTPsamples. Higher color and odor scores were recorded for the EnTPs. In addition, the encapsulated tomato powder had a significantly (p < 0.05) lower peroxide value (7.34 mEq/kg) and thiobarbituric acid (2.09 mg MDA/kg) in the sausages than in the other samples. In conclusion, the incorporation of EnTPsample as a polyphenol component in cocktail sausages is more advantageous than TP alone.
Advances in Porous Structure Design for Enhanced Piezoelectric and Triboelectric Nanogenerators: A Comprehensive Review
Authors: Turar Zhassulan , Sembay Merey , Mubarak Assem , Belgibayeva Ayaulym , Kong Long , Kalimuldina Gulnur 
Published: November 2024

AbstractPorous structures offer several key advantages in energy harvesting, making them highly effective for enhancing the performance of piezoelectric and triboelectric nanogenerators (PENG and TENG). Their high surface area‐to‐volume ratio improves charge accumulation and electrostatic induction, which are critical for efficient energy conversion. Additionally, their lightweight and flexible nature allows for easy integration into wearable and flexible electronics. These combined properties make porous materials a powerful solution for addressing the efficiency limitations that have traditionally restricted nanogenerators. Recognizing these benefits, this review focuses on the essential role that porous materials play in advancing PENG and TENG technologies. It examines a wide range of porous materials, including aerogels, nano‐porous films, sponges, and 2D materials, explaining how their unique structures contribute to higher energy harvesting efficiency. The review also explores recent breakthroughs in the development of these materials, demonstrating how they overcome performance challenges and open up new possibilities for practical applications. These advancements position porous nanogenerators as strong candidates for use in wearable electronics, smart textiles, and Internet of Things (IoT) devices. By exploring these innovations, the review underscores the importance of porous structures in driving the future of energy harvesting technologies.
The Impact of Individual and Team‐Level Variables on Burnout in Healthcare Providers
Authors: Gisick Logan M. , Korentsides Jenna , Keebler Joseph R. , Lazzara Elizabeth H. , Greilich Philip E. , Matulevicius Susan 
Published: November 2024

ABSTRACTThis study evaluates the relationships between individual and team‐level factors in influencing burnout among clinical healthcare providers. Focusing on psychological safety, perceived autonomy, perceived team effectiveness, and emotional intelligence, the research aims to understand how these elements contribute to the prevalence and severity of burnout symptoms. Using electronic questionnaires analyzed through Confirmatory Factor Analysis (CFA) and Structural Equation Modeling (SEM), the study sampled 180 healthcare providers from one large US medical center. The study results found that psychological safety significantly decreases levels of burnout, particularly emotional exhaustion. The results on team effectiveness suggest a complex relationship with burnout, with different dimensions having varied impacts. The study did not find support for the negative prediction of burnout by perceived autonomy and emotional intelligence, contrary to expectations based on prior research. These findings have practical implications for healthcare management, stressing the importance of psychological safety and effective team dynamics in reducing burnout. Overall, this study contributes significantly to understanding burnout in healthcare, emphasizing the critical role of team structures and individual emotional resilience in managing workplace well‐being.
The Prognostic Value of Serum Soluble Programmed Death 1 (sPD‐1) and Programmed Death Ligand 1 (sPD‐L1) in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis About Cohort Studies
Authors: Yu Qiyao , Li Jie , Mao Wenjie , Li Zheng , Li Xuan , Li Bin 
Published: November 2024

ABSTRACTBackground and AimsThere are still no useful biomarkers for the prognosis of esophageal squamous cell carcinoma (ESCC). In the prognosis of some kinds of cancer, soluble programmed death 1 (sPD‐1) and programmed death ligand 1 (sPD‐L1) have demonstrated statistical significance, but the prognostic value of serum sPD‐L1 and sPD‐1 remains unclear in ESCC.MethodsHere, a meta‐analysis was performed to estimate the prognostic value of sPD‐L1 and sPD‐1 in ESCC. To obtain eligible studies, we searched mainstream databases (PubMed, Cochrane, Embase, Web of Science, Wanfang Data, and CNKI), and the survival data including hazard ratios (HR) and its 95% confidence intervals (95% CI) from included literature were extracted.ResultsSix articles were included, including 645 patients with ESCC. The statistical result of this meta‐analysis indicated that serum sPD‐1 had no significant correlation with overall survival (OS) of patients with ESCC (p > 0.05). Patients with ESCC with high concentrations of serum sPD‐L1 demonstrated a significantly poor prognosis (HR = 1.73, 95% CI: 1.42–2.11, p < 0.001).ConclusionHigher levels of serum sPD‐L1 may predict poor OS in ESCC patients, which may be a promising and credible prognostic biomarker for esophageal cancer.
Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous and Intravenous Garadacimab Following Single‐Dose Administration in Healthy Japanese and White Adults
Authors: Glassman Fiona , Lawo John‐Philip , Bica Mihai Alexandru , Roberts Anthony , Pawaskar Dipti , Akama Hideto , Jain Meena , Goodson Summer 
Published: November 2024

AbstractGaradacimab, an activated factor XII (FXIIa) inhibitor monoclonal antibody, is being evaluated for the long‐term prophylaxis of hereditary angioedema. Here, we report the results from a two‐part, phase 1, open‐label, single ascending dose study assessing the pharmacokinetics (PK), pharmacodynamics, safety, and tolerability after subcutaneous (SC) and intravenous (IV) administration of garadacimab in healthy Japanese and White participants. Part 1 assessed garadacimab PK after SC administration of a 200 mg dose in weight‐matched White and Japanese participants, and 600 mg dose in Japanese participants. Part 2 assessed 3 and 10 mg/kg IV doses in Japanese participants. Follow‐up for safety was over 84 days post‐dose. Overall, 37 participants received garadacimab dosing and 36 completed the study, with one participant lost to follow‐up. Following SC administration, time to maximum plasma concentration (tmax) occurred at 7 days post‐dose, and garadacimab exposure, based on maximum plasma concentration (Cmax) and area under the plasma concentration–time curve (AUC), increased less than 3‐fold when tripling the dose. PK was comparable between Japanese and White participants, with geometric mean ratios for Cmax and AUC close to 100%. Following IV administration, tmax occurred at the end of infusion, and garadacimab exposure increased in a dose‐proportional manner. Inhibition of FXIIa‐mediated kallikrein activity versus baseline was observed in all participants receiving the SC and IV doses. No anti‐drug antibodies against garadacimab were reported. Consistent with pivotal phase 3 (VANGUARD) outcomes, no safety concerns and no difference in the safety profile of garadacimab were observed between healthy Japanese and White participants.
Assessing Association Between Circulating Bilirubin Levels and the Risk of Frailty: An Observational and Mendelian Randomization Study
Authors: Wu Jun , Xu Jia‐hao , Zou Hao‐qi , Ouyang Yi‐jiang , Li Shang‐jie , Wu Liang , Zhang Jie , Yin Ming‐Juan , Ye Dong‐qing , Ni Jin‐dong 
Published: November 2024

ABSTRACTBackgroundBilirubin is a by‐product of haemoglobin breakdown and has been reported to be a potent antioxidant recently. While elevated levels of bilirubin have been linked to a reduced risk of various diseases, their role remains unknown in frailty. This study aims to explore the relationship between serum bilirubin levels and the risk of frailty.MethodsThis cohort study included 442 223 White British participants (aged 39 to 73 years) with an available frailty index at baseline (2006 to 2010) from the UK Biobank. The associations of total/direct bilirubin levels with the continuous frailty index were analysed by multivariable linear regression, and multivariable logistic regression was used after classifying frailty outcomes into non‐frailty, pre‐frailty and frailty. A Mendelian randomization (MR) analysis was applied to evaluate the association of genetically predicted bilirubin levels with frailty risk.ResultsThe prevalence rates of both pre‐frailty and frailty were 46.17% and 12.49%, respectively, with higher rates observed in women than in men (pre‐frailty: 47.33% vs. 44.79%, frailty: 13.64% vs. 11.13%, respectively). There was a non‐linear negative association between total bilirubin levels and frailty indexes (p < 0.0001). Mildly elevated total bilirubin levels had protective effects against pre‐frailty (OR = 0.863, 95% CI: 0.849 to 0.879, p < 0.001) and frailty (OR = 0.660, 95% CI: 0.641 to 0.679, p < 0.001). Increased total bilirubin levels were more beneficial for women with frailty risk (percent changes per SD μmol/L = −0.37%, 95% CI: −0.40% to −0.34%). The MR analysis revealed a negative association between genetically predicted total/direct bilirubin levels and frailty risk (both p < 0.0001).ConclusionsCirculating total/direct bilirubin levels were negatively associated with frailty risk in White British individuals. Mildly elevated total bilirubin levels were more beneficial for women subpopulation.
Switching to Tenofovir Therapy Versus Continuation of Entecavir for Patients With Hepatitis B Virus Infection: A Systematic Review and Meta‐Analysis
Authors: Shahzil Muhammad , Chaudhary Ammad Javaid , Kashif Talha , Qureshi Ali Akram , Muhammad Anza , Khan Faiza , Faisal Muhammad Saad , Khaqan Muhammad Ali , Ali Hassam , Dababneh Yara , Moonka Dilip 
Published: November 2024

ABSTRACTBackgroundHepatitis B virus (HBV) infection causes liver disease, including hepatocellular carcinoma. Controlling viral activity is crucial to reducing complications. Tenofovir may offer benefits over entecavir, but it is unclear if switching from entecavir to tenofovir improves outcomes. This study assesses the clinical impact of switching to tenofovir therapy for chronic HBV infection.MethodsFollowing the PRISMA guidelines, we conducted a literature search within the Cochrane Library, PubMed, MEDLINE, Embase, and Scopus for studies of patients with HBV infection who were switched to tenofovir from entecavir or were maintained on entecavir. Both formulations of tenofovir, that is, tenofovir disoproxil fumarate and tenofovir alafenamide were included and analyzed in subgroup analysis. Meta‐analyses were performed with RevMan 5.4 using a random‐effects model, with statistical significance set at p < 0.05.ResultsA total of eight studies, comprising 833 patients, were included in the meta‐analysis. Tenofovir showed a significantly higher likelihood of achieving complete virological response (RR 5.60; 95% CI 3.51–8.94; p < 0.00001) and a greater reduction in HBV DNA levels (MD −1.03 log IU/mL; 95% CI −1.69 to −0.36; p = 0.002) compared to entecavir. However, there was no significant difference in HBsAg reduction or HBeAg seroconversion between the two groups. ALT reductions were not statistically significant overall, although entecavir showed better outcomes in subgroup analysis.ConclusionSwitching from entecavir to tenofovir improves virological response and reduces HBV DNA levels, but shows no significant advantage in HBsAg reduction, HBeAg seroconversion, or overall, ALT reduction.
Safety and efficacy of ketamine use in patients with vaso‐occlusive crisis: A systematic review and meta‐analysis
Authors: Calderon Martinez Ernesto , Zachariah Saji Stephin , Campos Carmona Thomas , Abbagoni Vaidarshi , Salman Mohammad , Llerena Vargas Mishell Estefanía , Mylavarapu Suchita , Fernando Druvini , Arvapalli Lakshmi Sheethal , Schettino Samad Nathalia , Karnan Nithin , Sanchez Cruz Camila 
Published: November 2024

AbstractIntroductionSickle cell disease (SCD) is characterized by acute episodes called vaso‐occlusive crises (VOC). VOC is marked by severe pain due to blocked blood vessels by sickled cells. Ketamine has been reported to be effective and safe in managing VOC in SCD patients.Objectives/methodsThis review aims to determine ketamine's safety and efficacy through analysis of clinical trials and observational studies.MethodsAdhering to PRISMA guidelines, this systematic review and meta‐analysis systematically searched seven databases on May 20, 2024 for randomized control trials (RCT), cohorts, and case–control studies.ResultsFive studies with 689 participants met the inclusion criteria. A meta‐analysis of two studies (518 observations) for the Numerical Rating Scale (NRS) pain score showed no significant difference, with a standardized mean difference (MD) of 0.23 (95% CI: −0.13 to 0.59, p = 0.21, I2 = 0%). For morphine milligram equivalent (MME), a meta‐analysis of two studies (344 observations) resulted in an MD of −0.03 (95% CI: −0.09 to 0.04, p = 0.45, I2 = 97%). However, the side effects analysis from four studies (608 observations) showed a significantly higher relative risk (RR) of 5.74 (95% CI: 2.80–11.79, p < 0.0001, I2 = 0%) for mild side effects, including nausea, vomiting, and dizziness.ConclusionKetamine qualitative synthesis shows potential for improving pain management in SCD patients during VOC, but without statistically significant differences in pain reduction. It is associated with increased mild side effects, though no severe adverse events were reported. Further research is needed to increase the sample size and power of the analysis to clarify optimal dosing and administration protocols for ketamine in this context.