bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Substance P Immunoreactivity in Ipsilateral Knee Cartilage of Rats Exposed to Lumbar Spine Injury
Authors: Duarte Felipe C. K. , Zwambag Derek P. , Brown Stephen H. M. , Clark Andrea , Hurtig Mark , Srbely John Z. 
Published: November 2018

Augmented expression of substance P (SP) in the cartilaginous tissue has been shown to promote degenerative changes in the cartilaginous matrix of distal contralateral articular joints via neurogenic inflammation post monoarthritis-induction contributing to the symmetrical spread of osteoarthritis (OA). However, no studies have explored whether similar changes are also present within neurosegmentally linked ipsilateral heterologous cartilage. Objective The present study aimed to investigate whether experimentally induced lumbar facet-joint OA lead to degenerative changes and enhanced SP expression within the ipsilateral neurosegmentally linked tibiofemoral cartilage. Methods Adult male Sprague-Dawley rats were assigned to left side L5-L6 facet mechanical compression injury (surgery) ( n = 6), L5-L6 facet exposure with no compression (sham) ( n = 5), or naïve (no surgery) ( n = 4) groups. The morphology of the tibiofemoral articular cartilage was assessed using a modified Mankin scoring system. Immunohistochemistry was used to examine the density of chondrocytes stained positive for SP (cells/cm2) in the ipsilateral tibiofemoral cartilage at 28 days postintervention. Results Tibiofemoral cartilage in the surgery group showed consistent loss of superficial zone chondrocytes, mild roughening of the articular surface and occasional chondrocyte clusters as well as a greater density of SP mainly in the superficial cartilage zone compared with sham and naïve groups, although they also had a basic SP-expression. Conclusion Our results support the hypothesis that neurogenic mechanisms may mediate the spread of SP to neurosegmentally linked heterologous joints affecting the distal cartilage homeostasis. These findings contribute additional insight into the potential role of neurogenic inflammation with implications in the pathophysiology of chronic inflammatory joint disease and OA.
Chronic pelvic pain in women: an embedded qualitative study to evaluate the perceived benefits of the meridian balance method electro-acupuncture treatment, health consultation and National Health Service standard care
Authors: Chong Ooi Thye , Critchley Hilary OD , Horne Andrew W , Fallon Marie , Haraldsdottir Erna 
Published: November 2018

Introduction: Chronic pelvic pain (CPP) – defined as intermittent or constant pain in the lower abdomen or pelvis of at least 6 months’ duration, not occurring exclusively with menstruation or intercourse and not associated with pregnancy – is estimated to affect 6–27% of women worldwide. In the United Kingdom, over 1 million women suffer from CPP, which has been highlighted as a key area of unmet need. Current medical treatments for CPP are often associated with unacceptable side effects. A specific style of acupuncture, the meridian balance method electro-acupuncture (BMEA) and traditional Chinese medicine health consultation (TCM HC (BMEA + TCM HC = BMEA treatment)), may be effective for CPP in women. Aim: Three focus group discussions and semi-structured telephone interviews were embedded in a randomised controlled feasibility trial to gain in-depth description of the perceived benefits of the participants’ respective interventions. Methods: Women with CPP were randomised into the BMEA treatment, TCM HC or National Health Service standard care (NHS SC). Focus group discussions were recorded, transcribed and analysed thematically. Semi-structured telephone interviews were conducted post focus group discussions. Findings: A total of 30 women were randomised into BMEA treatment, TCM HC or NHS SC. A total of 11 participants attended the three focus group discussions. Thematic analysis of focus group discussions showed: a perceived pain reduction, enhanced sleep, energy level and sense of well-being in the BMEA treatment and TCM HC groups; a dislike for the adverse effects of medications, frustration at the lack of effective treatment, heavy reliance on medications and services that are helpful, in the NHS SC group. Semi-structured telephone interviews showed that the methodology was acceptable to the participants. Conclusion: The embedded focus group discussions captured the rich and complex narratives of the participants and provided insights into the perceived benefits of the BMEA treatment, TCM HC and NHS SC interventions.
Admitting Service Affects Cost and Length of Stay of Hip Fracture Patients
Authors: Lott Ariana , Haglin Jack , Belayneh Rebekah , Konda Sanjit R. , Egol Kenneth A. 
Published: November 2018

Introduction: The purpose of this study was to analyze the effect of the admitting service on cost of care for hip fracture patients by comparing the cost difference between patients admitted to the medicine service versus those admitted to a surgical service. Methods: A 2-year cohort of patients 55 years or older who were admitted to a single level 1 trauma center with an operative hip fracture were included. Patient demographics, comorbidities, admitting service, complications, and hospital length of stay were recorded for each patient. Cost of hospitalization, discharge disposition, and 30-day readmissions were collected. Patients who were admitted to the medicine service (medicine cohort) were compared to those admitted to a surgery service (surgery cohort). Multivariate regression models controlling for age, Charlson comorbidity index (CCI), and American Society of Anesthesiology (ASA) scores were used to evaluate hospitalization costs with a P value of <.05 as significant. Results: Two hundred twenty-five hip fracture patients were included; 143 (63.6%) patients were admitted to a surgical service, while 82 (36.4%) were admitted to the medicine service. Patients admitted to medicine service had greater CCI and ASA scores, longer lengths of stay, and more complications than those patients admitted to surgery service. Linear regression model controlling for age, CCI, ASA score, and time to surgery demonstrates that patients admitted to a surgical service will have 2.0-day (95% confidence interval [CI]: 0.561-3.503; P = .007) shorter admissions with a US$4215 reduction in cost (95% CI: US$314-US$8116; P = .034) compared to patients admitted to the medicine service. Discussions: In our urban safety net hospital, hip fracture patients admitted to medicine service had longer lengths of stay and higher total hospitalization costs than patients who were admitted to surgery service. Conclusions: This study highlights that the admitting service should be an area of focus for hospitals when developing programs to provide effective and cost-conscious care to hip fracture patients.
A Population-Based Investigation of Health-Care Needs and Preferences in American Adults With Multiple Sclerosis
Authors: Chiu Chungyi , Bishop Malachy , McDaniels Bradley , Kim Byung-Jin , Tiro Lebogang 
Published: November 2018

Background: Comprehensive and effective multiple sclerosis (MS) health care requires understanding of patients’ needs, preferences, and priorities. Objective: To evaluate priorities of patients with MS for their MS care. Methods: Participants included 3003 Americans with MS recruited through the National MS Society and the North American Research Committee on Multiple Sclerosis patient registry. Participants completed a comprehensive questionnaire on aspects of their health-care experiences. Results: Participants identified the top 3 health-care priorities as (1) the affordability of MS health care, (2) ensuring that non-MS health-care providers have more education about MS and how it can interact with other conditions, and (3) access to an MS center or specialized MS clinic with MS health-care professionals together in one place. Participants receiving care in an MS center rated the quality and their satisfaction with care higher than those receiving care in other settings. Although having the opportunity to evaluate their health-care quality was important to the participants, only 36.4% had been provided the opportunity in the past year. Conclusions: This study identifies health-care priorities and concerns for Americans with MS.
Comparison of the clinical phenotype of systemic sclerosis patients in Iran and France in two university centers
Authors: Allanore Yannick , Gharibdoost Farhad , Jamshidi Ahmad Reza , Javinani Ali , Avouac Jérôme , Rastkar Elnaz , Hooshmandi Sadid , Kavosi Hoda 
Published: November 2018

Objectives: Systemic sclerosis is a severe and rare chronic auto-immune multisystem disorder characterized by vasculopathy and skin stiffness. Ethnic and geographical origin can influence the outcomes. In this study, we compared the phenotypic characteristics of Iranian and French patients. Methods: This cross-sectional study was performed on 200 Iranian and 268 French systemic sclerosis patients. Iranian patients collected from the Iranian systemic sclerosis cohort of the Rheumatology Research Center, Shariati hospital, Tehran University of Medical Sciences. The French population was monocentric, and it was constituted by the patients included locally in the EUSTAR database in December 2016. Results: The mean age at onset was significantly lower in Iranian patients (35.58 ± 11.68 vs 47.06 ± 13.54, p-value < 0.001). The female-to-male ratio was approximately 5.2:1 and was not different in the two populations. The prevalence of diffuse cutaneous systemic sclerosis was significantly higher in Iranian patients (60.2% vs 42.85%, p-value < 0.001). Calcinosis cutis and joint synovitis were more prevalent in French patients ( p-value = 0.013, <0.001). The positivity of anti-topoisomerase antibody was higher in Iranian patients, whereas the anti-centromere antibody predominated in French cases ( p-value < 0.001). Restrictive pattern of pulmonary function test was more common in Iranian patients ( p-value < 0.001), while estimated pulmonary arterial pressure by echocardiography was higher in French patients ( p-value < 0.001). Conclusion: It seems that systemic sclerosis occurred in younger ages among Iranian female with the predominance of diffuse cutaneous subtype. In addition, lung interstitial disease appeared to be more prevalent and severe in Iranians than French patients.
How I treat infant leukemia
Authors: Brown Patrick , Pieters Rob , Biondi Andrea 
Published: November 2018

Abstract
Leukemia in infants is rare but generates tremendous interest due to its aggressive clinical presentation in a uniquely vulnerable host, its poor response to current therapies, and its fascinating biology. Increasingly, these biological insights are pointing the way toward novel therapeutic approaches. Using representative clinical case presentations, we review the key clinical, pathologic, and epidemiologic features of infant leukemia, including the high frequency of KMT2A gene rearrangements. We describe the current approach to risk-stratified treatment of infant leukemia in the major international cooperative groups. We highlight recent discoveries that elucidate the molecular biology of infant leukemia and suggest novel targeted therapeutic strategies, including modulation of aberrant epigenetic programs, inhibition of signaling pathways, and immunotherapeutics. Finally, we underscore the need for increased global collaboration to translate these discoveries into improved outcomes.
Investigation of a Carbapenemase-producing Acinetobacter baumannii outbreak using whole genome sequencing versus a standard epidemiologic investigation
Authors: Bogaty Chloe , Mataseje Laura , Gray Andrew , Lefebvre Brigitte , Lévesque Simon , Mulvey Michael , Longtin Yves 
Published: November 2018

Abstract
Background
The standard epidemiologic investigation of outbreaks typically relies on spatiotemporal data and pulsed-field gel electrophoresis (PFGE), but whole genome sequencing (WGS) is becoming increasingly used. This investigation aimed to characterize a carbapenemase-producing Acinetobacter baumannii (CPAb) nosocomial outbreak using WGS compared to a standard outbreak investigation.

Methods
The CPAb outbreak occurred in a single center between 2012 and 2014. The standard investigation used spatiotemporal data and PFGE to generate a chain of transmission. A separate WGS investigation generated a chain of transmission based solely on WGS and date of sampling and was blinded to all other spatiotemporal data and PFGE. Core single nucleotide variant (SNV) phylogenetic analysis was performed on WGS data generated using the Illumina MiSeq platform. The chains of transmission were compared quantitatively and qualitatively to assess the concordance between both methods.

Results
28 colonized and infected cases were included. Of the 27 transmission events identified using the standard investigation, 12 (44%) were identical to the transmission events using WGS. WGS identified several transmission events that had not been detected by traditional method, and numerous transmission events that had occurred on different hospital wards than suspected by standard methods. The average number (standard deviation [SD]) of SNVs per transmission events was 1.63 (SD, 1.31) by traditional method and 0.63 (SD, 0.79) by WGS (p = 0.001) All isolates harbored the rare carbapenemase blaOXA-237.

Conclusions
The traditional and WGS investigations had moderate concordance. When used alongside epidemiologic data and clinical information, WGS could help improve the mapping of transmission events.
Brain Metastases From Differentiated Thyroid Carcinoma: Prevalence, Current Therapies, and Outcomes
Authors: Gomes-Lima Cristiane J , Wu Di , Rao Sarika N , Punukollu Sree , Hritani Rama , Zeymo Alexander , Deeb Hala , Mete Mihriye , Aulisi Edward F , Van Nostrand Douglas , Jonklaas Jacqueline , Wartofsky Leonard , Burman Kenneth D 
Published: November 2018

Abstract

Background and Objective
The brain is an unusual site for distant metastases of differentiated thyroid carcinoma (DTC). The aim of this study was to document the prevalence of brain metastases from DTC at our institutions and to analyze the current therapies and the outcomes of these patients.

Methods
We performed a retrospective chart review of patients with DTC and secondary neoplasia of the brain.

Results
From 2002 to 2016, 9514 cases of thyroid cancer were evaluated across our institutions and 24 patients met our inclusion criteria, corresponding to a prevalence of 0.3% of patients with DTC. Fourteen (58.3%) were female and 10 (41.7%) were male. Fifteen patients had papillary thyroid cancer (PTC) (62.5%). Brain metastases were diagnosed 0 to 37 years (mean ± SD, 10.6 ± 10.4 years) after the initial diagnosis of thyroid cancer. Patients undergoing surgery had a median survival time longer than those that did not undergo surgery (27.3 months vs 6.8 months; P = 0.15). Patients who underwent stereotactic radiosurgery (SRS) had a median survival time longer than those that did not receive SRS (52.5 months vs 6.7 months; P = 0.11). Twelve patients (50%) were treated with tyrosine kinase inhibitors (TKIs), and they had a better survival than those who have not used a TKI (median survival time, 27.2 months vs 4.7 months; P &lt; 0.05).

Conclusion
The prevalence of brain metastases of DTC in our institutions was 0.3% over 15 years. The median survival time after diagnosis of brain metastases was 19 months. In our study population, the use of TKI improved the survival rates.
Design and protocol for a pragmatic randomised study to optimise screening, prevention and care for tuberculosis and HIV in Malawi (PROSPECT Study)
Authors: MacPherson Peter , Webb Emily L , Lalloo David G. , Nliwasa Marriott , Maheswaran Hendramoorthy , Joekes Elizabeth , Phiri Dama , Squire Bertie , Pai Madhukar , Corbett Elizabeth L 
Published: November 2018

Background: Adults seeking diagnosis and treatment for tuberculosis (TB) and HIV in low-resource settings face considerable barriers and have high pre-treatment mortality. Efforts to improve access to prompt TB treatment have been hampered by limitations in TB diagnostics, with considerable uncertainty about how available and new tests can best be implemented. Design and methods: The PROSPECT Study is an open, three-arm pragmatic randomised study that will investigate the effectiveness and cost-effectiveness of optimised HIV and TB diagnosis and linkage to care interventions in reducing time to TB diagnosis and prevalence of undiagnosed TB and HIV in primary care in Blantyre, Malawi. Participants (≥ 18 years) attending a primary care clinic with TB symptoms (cough of any duration) will be randomly allocated to one of three groups: (i) standard of care; (ii) optimised HIV diagnosis and linkage; or (iii) optimised HIV and TB diagnosis and linkage. We will test two hypotheses: firstly, whether prompt linkage to HIV care should be prioritised for adults with TB symptoms; and secondly, whether an optimised TB triage testing algorithm comprised of digital chest x-ray evaluated by computer-aided diagnosis software and sputum GeneXpert MTB/Rif can outperform clinician-directed TB screening. The primary trial outcome will be time to TB treatment initiation by day 56, and secondary outcomes will include prevalence of undiagnosed TB and HIV, mortality, quality of life, and cost-effectiveness. Conclusions: The PROSPECT Study will provide urgently-needed evidence under “real-life” conditions to inform clinicians and policy makers on how best to improve TB/HIV diagnosis and treatment in Africa. Clinical trial registration: NCT03519425 (08/05/2018)
Modelos de Espaço Público em contraste: Imprensa e Modernidade Seletiva nas Províncias da Paraíba e Pernambuco (1870-1880)
Authors: Zica Matheus Da Cruz e , Oliveira Patrícia Barros de 
Published: November 2018

Este artigo procura elucidar o debate que se constituiu pela imprensa ao longo das décadas de 1870 e 1880 nas províncias brasileiras da Paraíba e de Pernambuco em torno do modelo francês de monarquia parlamentar que contrastava com o federalismo republicano dos EUA. Assumindo o lugar de formadora da opinião pública a imprensa procurou trazer destaque para a questão do Espaço Público na medida em que modos distintos de se lidar com ele estavam em jogo em cada um daqueles modelos políticos internacionais idealizados. Também foram mapeadas algumas relações que os jornais analisados indiciaram entre os debates sobre o Espaço Público e as retóricas de modernidade que os acompanhavam. Com frequência a questão da ciência e da técnica pareceu eclipsar a dimensão do conflito que é próprio do universo político e da esfera pública, unificando os olhares em torno de um deslumbramento com as benfeitorias materiais que o século prometia.Palavras chave: Espaço Público, Formação, Imprensa. AbstractThis article seeks to elucidate the debate that was constituted by the press throughout the 1870s and 1880s in the Brazilian provinces of Paraíba and Pernambuco around the French model of parliamentary monarchy that contrasted with the republicanism of the USA. Taking over the role of public opinion maker, the press sought to highlight the issue of the Public Space since that distinct ways of dealing with it was considered in each of those idealized international political models. This article also mapped some relations that the newspapers analyzed betrayed between the debates on the Public Space and the rhetoric of modernity that accompanied them. Often the question of science and technique seemed to eclipse the dimension of conflict that is proper to the political universe and the public sphere, unifying the glances around a dazzle with the material improvements that the century promised.Keywords: Public Space, Formation, Press. ResumenEste artículo busca esclarecer el debate que se constituyó por la prensa a lo largo de las décadas de 1870 y 1880 en las provincias brasileñas de Paraíba y de Pernambuco en torno al modelo francés de monarquía parlamentaria que contrastaba con el federalismo republicano de EUA. Asumiendo el lugar de formadora de la opinión pública la prensa trató de destacar la cuestión del Espacio Público en la medida en que modos distintos de lidiar con él estaban en juego en cada uno de aquellos modelos políticos internacionales idealizados. También se han mapeado algunas relaciones que los periódicos analizados indiciaron entre los debates sobre el espacio público y las retóricas de modernidad que los acompañaban. Con frecuencia la cuestión de la ciencia y de la técnica parecía eclipsar la dimensión del conflicto que es propio del universo político y de la esfera pública, unificando las miradas en torno a un deslumbramiento con las mejoras materiales que el siglo prometía.Palabras clave: Espacio Público, Formación, Prensa.
Impact of counseling on cervical cancer and its screening on women knowledge, health beliefs and protective practices
Authors: HosseAbedelAzim Mohamedin Hoda , El-sayed Hossein Yosria 
Published: November 2018

Background: Cervical cancer can be preventable or detected early especially with a series of regular screening with Pap tests.Aim of the study: The aim of this study were to evaluate the impact of counseling on cervical cancer and its screening on women knowledge, health beliefs and protective practices.Subjects and Methods: A quasi-experimental design was used. A convenient ample of 120 women were randomly divided into experimental and control groups, each group consisted of 60 women were recruited from outpatient clinic at Obstetrics and Gynecology Department at Minia General Hospital.Results It can be observed that, 86% of the women in the intervention group had good knowledge compared to only 17% of the control group and the difference is statistically significant. The mean score of perceived susceptibility and barriers in both groups was reduced but the decrease was significantly higher in the intervention group (P<0.004). The mean score of perceived severity and benefits in both groups were increased, but the increased mean score in the intervention group was higher. A highly statistical significant difference was observed between groups regarding protective practices (p = .001).Conclusion: It can be concluded that there was a highly statistical significant improvement in women knowledge was observed and the higher positive beliefs about perceived benefits of preventive health practices, susceptibility, severity, health motivation and reduced the barriers of pap smear this can influence womenâ€™s willingness to take preventive test and higher participation in regular Pap smear test in the intervention group. The most commonly barriers to screening cited in our study are lack of knowledge.Recommendations: on the light of this findings it is recommended that, women should be encouraged to take responsibility for their own health and be active participants in the screening program, More educational intervention is needed to encourage adherence to routine cancer screening with raising womenâ€™s awareness about cervical cancer, The barriers to Pap smear test are considered by the health authorities in order to overcome barriers of cervical cancer screening.Â Â