bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating palaeobathymetry with quantified uncertainties: a workflow illustrated with South Atlantic data
Authors: Pérez-Díaz L. , Eagles G. 
Published: March 2018

Abstract
We present and illustrate a workflow to produce palaeobathymetric reconstructions, using examples from the South Atlantic Ocean. With a recent high-resolution plate kinematic model as the starting point, we calculate an idealized basement surface by applying plate-cooling theory to seafloor ages and integrating the results with depths along the extended continental margins. Then, we refine the depths of this basement surface to account for the effects of sedimentation, variations in crustal thickness and dynamic topography. Finally, the corrected idealized surface is cut along appropriate plate outlines for the desired time slice and reconstructed using appropriate Euler parameters.
In order to assess the applicability of modelled results, we critically examine the limitations and uncertainties resulting from the datasets used and assumptions made. Palaeobathymetry modelled with our approach is likely to be least reliable over parts of large igneous provinces close to the times of their eruption, and most reliable within the oceanic interiors for Neogene time slices. The uncertainty range is not smaller than 500 m for any significant region at any time, and its mean over 95% of locations in all time slices is close to 1800 m.
Pre-treatment Dietary Patterns Are Associated with the Presence of Symptoms 1 Year after Diagnosis in Patients with Head and Neck Cancer
Authors: Crowder SL , Mondul AM , Tang YC , Pepino MY , Sarma KP , Rozek LS , Wolf GT , Arthur AE 
Published: March 2018

Abstract
Ninety percent of head and neck cancer (HNC) survivors experience disease and treatment related symptoms. Diet has the potential to reduce inflammation, modulate epigenetic changes and affect biological processes involved in the pathogenesis of symptoms. The objective of this study was to determine if pre-treatment dietary patterns are associated with the presence of symptoms 1-year after diagnosis. Methods: This was a longitudinal study of 295 newly diagnosed HNC patients. All patients completed a food frequency questionnaire and epidemiologic health survey. Self-reported symptoms were assessed pre-treatment and 1-year after diagnosis using a Likert scale ranging from “1: not at all bothered” by symptom to “5: extremely bothered”. Symptom scores were dichotomized as “not at all” vs. “slight - extremely”. Principal component analysis was used to derive pre-treatment dietary patterns. Multivariable logistic regression models examined the association of derived dietary patterns (fit by quartiles) and seven symptoms (trismus, xerostomia, dysphagia of liquids, dysphagia of solids, difficulty chewing, taste and mucositis). An overall symptom summary score was calculated (range 8–39) and dichotomized as &lt;17 vs. ≥17. This cut-off was chosen by examining the distribution of scores and categorizing into two distinct subgroups naturally present in the data. Results: Two dietary patterns emerged: Prudent (high intakes of vegetables, fruit, fish, poultry, and whole grains) and Western (high intakes of red and processed meats, refined grains, potatoes, and French fries). After adjusting for age, baseline symptoms, tumor site, cancer stage, smoking, calories and HPV status, significant inverse associations were observed between pre-treatment Prudent pattern score and dysphagia of liquids (P = 0.01), dysphagia of solids (P = 0.02) and difficulty chewing (P = 0.02) at 1 year post- diagnosis. A statistically significant inverse association was observed between the overall symptom summary score and the Prudent pattern (P &lt; 0.001). No significant associations were observed between the Western pattern and symptoms. Conclusion: Consumption of a pre-treatment Prudent diet may help reduce the risk of symptoms such as dysphagia and difficulty chewing 1-year after diagnosis in HNC survivors.
Sleep and Cancer Incidence in Alberta's Tomorrow Project Cohort
Authors: McNeil J , Barberio A , Friedenreich CM , Brenner DR 
Published: March 2018

Abstract
We aimed to investigate the association between self-reported sleep duration and sleep timing midpoint with all- and site-specific cancer incidence in Alberta's Tomorrow Project (ATP) cohort. Methods: The analysis for sleep duration included 46,300 Albertans aged 35–65 years at baseline from the ATP cohort recruited from 2001–2015. Sleep timing midpoint (wake-time – ½ sleep duration) was assessed in a subset of ATP participants (n = 19,820). Cancer incidence was determined through record linkage with the Alberta Cancer Registry in December 2016. Cox proportional hazard regression models evaluated the effects of sleep duration and sleep timing midpoint categories on all- and site-specific (breast, colorectal, lung, prostate, endometrial and hematologic) cancer incidence. Models were adjusted for age, sex (non sex-specific cancers), highest level of education, total household income, marital status, alcohol intake, smoking status, body mass index, family history of cancer, presence of at least one medical condition/co-morbidity, menopausal status (female cancers only) and sleep duration (sleep timing midpoint analysis only). Results: By 2016, there were 3,034 incident cases of cancer in this cohort. A statistical trend was noted for an increased risk of all cancers in participants reporting &gt; 9 hours of sleep/night compared to 7–9 hours of sleep/night (hazard ratio (HR) = 1.16, 95% confidence interval (CI): 0.98–1.36; P = 0.08). Reporting &gt; 9 hours of sleep/night compared to 7–9 hours of sleep/night was also associated with an increased incidence of endometrial cancer (HR = 2.09, 95% CI: 1.16–3.76; P = 0.01). A later sleep timing midpoint (&gt;4:08 AM) versus an intermediate sleep timing midpoint (3:47 AM–4:08 AM) was associated with an increased risk of all (HR = 1.19, 95% CI: 1.03–1.37; P = 0.02) and breast (HR = 1.64, 95% CI: 1.18–2.26; P = 0.003) cancer incidence. Conclusions: These novel findings provide evidence regarding the important role of sleep in cancer etiology. Interventions that put emphasis on proper sleep hygiene for cancer prevention are needed.
Using Social Media to Reduce Multiple Risk Factors for CRC in Rural Appalachians: #CRCFREE
Authors: Voigts K , Adegboyega A , Bush H , Hatcher J 
Published: March 2018

Abstract
Purpose: To examine the efficacy, acceptability, feasibility, and applicability of a Facebook (FB) intervention designed to reduce multiple colorectal cancer (CRC) risk factors in older adults residing in rural Appalachian Kentucky. Methods: We piloted a 12 week FB intervention culturally tailored for older adults residing in rural Eastern Kentucky to impact CRC risk factors, including: nutrition, physical activity, and screening. Participants were aged 50+, had internet access, and were at risk for CRC. During the 12 week study, the participants received three daily posts via secret FB group regarding CRC risk factors. Demographics, dietary measures, body mass index (BMI), and CRC screening were assessed at baseline and post intervention. FB engagement and physical activity were tracked throughout the intervention. Dietary measures included the Healthy Eating Index (HEI) and Dietary Inflammatory Index (DII). Physical activity was tracked using Fitbits. Post-intervention focus group interviews were conducted to assess feasibility and acceptability. Results: Participants (n = 57) were Caucasian, aged 58 ± 6 years, predominately female (67%), and the majority reported at least a high school education (77%). Post intervention, participants experienced significant increase in HEI scores (49.94 ± 9.84 vs. 58.60 ± 12.06, P = &lt; 0.01). DII scores significantly decreased (2.44 ±1.12 vs. 1.60 ± 1.63, P = 0.003). There was no significant change in physical activity, BMI, or screening status. Participants, on average, viewed more than half of the posts. Focus group participants found FB posts to be useful and motivating. They reported that FB posts were educational and motivational. Conclusion: This pilot study shows promising preliminary data to support using a FB intervention in rural Appalachian older adults to decrease CRC risks. Participants were receptive to FB intervention, and FB provides a unique and accessible method for health promotion in hard to reach populations.
Global ECG Measures and Cardiac Structure and Function
Authors: Biering-Sørensen Tor , Kabir Muammar , Waks Jonathan W. , Thomas Jason , Post Wendy S. , Soliman Elsayed Z. , Buxton Alfred E. , Shah Amil M. , Solomon Scott D. , Tereshchenko Larisa G. 
Published: March 2018

Background:
Electric excitation initiates myocardial mechanical contraction and coordinates myocardial pumping. We hypothesized that ECG global electric heterogeneity (GEH) and its longitudinal changes are associated with cardiac structure and function.

Methods and Results:

Participants from the ARIC study (Atherosclerosis Risk in Communities) (N=5114; 58% female; 22% blacks) with resting 12-lead ECGs (visits 1–5) and echocardiographic assessment of left ventricular (LV) ejection fraction, LV global longitudinal strain, LV mass index, LV end-diastolic volume index, and LV end-systolic volume index at visit 5 were included. Longitudinal analysis included ARIC participants (N=14 609) with measured GEH at visits 1 to 4. GEH was quantified by spatial ventricular gradient, QRS-T angle, and sum absolute QRS-T integral. Cross-sectional and longitudinal regressions were adjusted for manifest and subclinical cardiovascular disease. Having 4 abnormal GEH parameters was associated with a 6.4% (95% confidence interval, 5.5–7.3) LV ejection fraction decline, a 24.2 g/m
2
(95% confidence interval, 21.5–26.9) increase in LV mass index, a 10.3 mL/m
2
(95% confidence interval, 8.9–11.7) increase in LV end-diastolic volume index, and a 7.8 mL/m
2
(95% confidence interval, 6.9–8.6) increase in LV end-systolic volume index. Altogether, clinical and ECG parameters accounted for approximately one third of LV volume and 20% of systolic function variability. The associations were significantly stronger in cardiovascular disease. Sum absolute QRS-T integral increased by 20 mV*ms for each 3-year period in participants who demonstrated LV dilatation at visit 5. Sudden cardiac death victims demonstrated rapid GEH worsening, whereas those with LV dysfunction demonstrated slow GEH worsening. Healthy aging was associated with a distinct pattern of spatial ventricular gradient azimuth decrement.

Conclusions:
GEH is a marker of subclinical abnormalities in cardiac structure and function.
Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion
Authors: Desilles Jean‐Philippe , Syvannarath Varouna , Di Meglio Lucas , Ducroux Célina , Boisseau William , Louedec Liliane , Jandrot‐Perrus Martine , Michel Jean‐Baptiste , Mazighi Mikael , Ho‐Tin‐Noé Benoît 
Published: March 2018

Background
Previous experimental studies have shown that downstream microvascular thromboinflammation is involved in brain damage from acute ischemic stroke. Using intravital microscopy, we investigated and characterized the sequence of downstream microvascular thromboinflammation in an ischemia/reperfusion acute ischemic stroke model.

Methods and Results

Rats underwent transient monofilament middle cerebral artery (MCA) occlusion. Cerebral microcirculation in the
MCA
territory was exposed through a craniotomy and analyzed using real‐time intravital imaging coupled with laser Doppler interferometry. Leukocytes, platelets, fibrinogen, and blood–brain barrier permeability were analyzed by intravenous injection of fluorescent antibodies and bovine serum albumin. MCA occlusion induced a sudden and profound drop in downstream microvascular blood flow associated with leukocyte margination in the venous compartment. Leukocyte margination fostered fibrinogen deposition and thrombosis in postcapillary venules. Either in venules or arterioles, blood flow was not fully restored after
MCA
recanalization. Furthermore, venular thrombi persisted despite
MCA
recanalization, and leukocyte extravasation continued to develop in venules in association with blood–brain barrier disruption. Finally, microhemorrhages were occasionally observed, colocalizing with thrombosed venules characterized by marked leukocyte margination.

Conclusions

We showed that microvascular thrombosis in transient monofilament MCA occlusion and blood–brain barrier disruption are initiated immediately after occlusion and are propagated through the venous compartment in close association with marginating leukocytes. MCA occlusion–induced downstream microvascular thromboinflammation response was responsible for incomplete reperfusion after
MCA
recanalization and delayed microhemorrhages.
‘Global Sociology’ from a Comparative Perspective: A Multidimensional Analysis
Authors: Sorokin Pavel 
Published: March 2018

AbstractThis paper applies a comparative approach to analyze several dimensions of ‘Global Sociology’ from a normative stance based on a critical review of related discourses in sociological communities. The author reveals three major problems in intra-disciplinary, inter-disciplinary and extra-academic dimensions, manifested not only in ‘factual’ (objective) characteristics but also in ‘ideological’ visions typical of academic communities and connected with a negative stance towards global neoliberalism and its various agents: first, rigid vertical stratification of the international academic field, primarily, in terms of academic publishing and working conditions; second, negative tendencies in the status positions of sociology compared to other sciences, especially economics; and third, little cooperation with policy-makers and corporate practitioners combined with an orientation to supporting various discriminated groups against dominating powers associated with neoliberalism.
Human Rights: Why Countries Differ
Authors: Rindermann Heiner , Carl Noah 
Published: March 2018

AbstractCountries differ with respect to human rights. Using the cross-countryciridata (Cingranelli & Richards), the authors tested two theories. The cognitive-moral enlightenment theory going back to Piaget and Socrates postulates that individuals and nations with higher levels of cognitive ability think and behave in a way more conducive to human rights. The culture-religion theory going back to Weber, Sombart and Voltaire postulates that different religious beliefs shape attitudes, and propel societies toward institutions that are more or less supportive of human rights. Cognitive ability had a positive impact on human rights but its effect varied depending on the country sample. More important was religion, both in cross-sectional and longitudinal models. Percentage of Christians had a positive impact (r= .62, total effectβ= .63), percentage of Muslims had a negative one (r= −.57, total effectβ= −.59). Political institutions are highly correlated with human rights, but religion is the decisive background factor.
Social Topography for Sustainable Innovation Policy: Putting Institutions, Social Networks and Cognitive Frames in Their Place
Authors: Modic Dolores , Rončević Borut 
Published: March 2018

AbstractBuilding upon social fields theory, the authors analyze the impact of the three social forces – institutions, social networks and cognitive frames – on the social topography of regional innovation systems. Unlike previous studies, which focused on individual social force, the authors’ fuzzy-set comparative analysis of fifteen diverse regions from four continents reveals nuanced impact of individual forces and shows that a well-functioning regional innovation system is the outcome of their combined influence. This implies a need for a coherent, reflexive, context-specific and multi-level innovation policy that supports the balanced development of an institutional framework, encourages the formation of social networks and enables supportive cognitive frames.
Clinical significance of centripetal propagation of vasoconstriction in patients with reversible cerebral vasoconstriction syndrome: A retrospective case-control study
Authors: Shimoda Masami , Oda Shinri , Shigematsu Hideaki , Hoshikawa Kaori , Imai Masaaki , Komatsu Fuminari , Hirayama Akihiro , Osada Takahiro 
Published: March 2018

Introduction We previously reported centripetal propagation of vasoconstriction at the time of thunderclap headache remission in patients with reversible cerebral vasoconstriction syndrome. Here we examine the clinical significance of centripetal propagation of vasoconstriction. Methods Participants comprised 48 patients who underwent magnetic resonance angiography within 72 h of reversible cerebral vasoconstriction syndrome onset and within 48 h of thunderclap headache remission. Results In 24 of the 48 patients (50%), centripetal propagation of vasoconstriction occurred on magnetic resonance angiography at the time of thunderclap headache remission. The interval from first to last thunderclap headache in patients with centripetal propagation of vasoconstriction (14 ± 10 days) was significantly longer than that of patients without centripetal propagation of vasoconstriction (4 ± 2 days). In the patients with centripetal propagation of vasoconstriction at the time of thunderclap headache remission, the incidence of another cerebral lesion (38%, 9 of 24 cases) was significantly higher than in patients without centripetal propagation of vasoconstriction (0%). From findings of sequential magnetic resonance angiography before and after thunderclap headache remission, we observed tendencies in which centripetal propagation of vasoconstriction gradually progressed after the onset of reversible cerebral vasoconstriction syndrome and peaked at the time of thunderclap headache remission. The progress of centripetal propagation of vasoconstriction concluded with thunderclap headache remission. Conclusions Centripetal propagation of vasoconstriction has clinical significance as an indicator of the severity of reversible cerebral vasoconstriction syndrome. The presence of centripetal propagation of vasoconstriction is associated with an increased risk of brain lesions and a longer interval from first to last thunderclap headache. Moreover, repeat magnetic resonance angiography to assess centripetal propagation of vasoconstriction during the time from onset to thunderclap headache remission can help diagnose reversible cerebral vasoconstriction syndrome.
Alteration of Knee Kinematics After Anatomic Anterior Cruciate Ligament Reconstruction Is Dependent on Associated Meniscal Injury
Authors: Akpinar Berkcan , Thorhauer Eric , Irrgang James J. , Tashman Scott , Fu Freddie H. , Anderst William J. 
Published: March 2018

Background: Limited in vivo kinematic information exists on managing meniscal injury during anterior cruciate ligament reconstruction (ACLR). Hypothesis: Isolated anatomic ACLR restores knee kinematics, whereas ACLR in the presence of medial meniscal injury is associated with altered long-term knee kinematics. Study Design: Cohort study; Level of evidence, 3. Methods: From March 2011 to December 2012, 49 of 57 participants in a clinical trial underwent anatomic ACLR with successful kinematic testing at 24 months after ACLR. Twenty-five patients had associated meniscal tears: medial (n = 11), lateral (n = 9), or bilateral (n = 5). With a dynamic stereo radiography system with superimposed high-resolution computed tomography scans of patient knees, kinematics were measured during downhill running. The initial single-support phase of the gait cycle (0%-10%) was analyzed. Results: Anterior tibial translation (ATT) was the only kinematic outcome between patients’ ACLR and contralateral knees that had significant interactions among meniscal groups ( P = .007). There was significant difference in ATT between patients with intact menisci and medial tears ( P = .036) and with medial tears and lateral tears ( P = .025). Patients with intact menisci had no difference in ATT, with a negligible effect size between the ACLR and contralateral knees (mean ± SEM: 13.1 ± 0.7 mm vs 12.6 ± 0.5 mm, P = .24, Cohen d = 0.15, n = 24), while patients with medial meniscal tears had an increase in ATT, with a medium effect size between the ACLR and contralateral knees (15.4 ± 1.0 mm vs 13.2 ± 1.0 mm, P = .024, Cohen d = 0.66, n = 11). Conclusion: Associated medial meniscal injury in the setting of ACLR leads to increased ATT at 24-month follow-up. Furthermore, isolated anatomic ACLR in the absence of meniscal injury demonstrated no significant difference from native knee kinematics at 24-month follow-up during rigorous “high demand” knee activity with the current sample size. Patients undergoing anatomic ACLR in the presence of medial meniscal injury remained at a higher likelihood of sustaining altered long-term knee kinematics.
Impact of moral sensitivity on moral distress among psychiatric nurses
Authors: Ohnishi Kayoko , Kitaoka Kazuyo , Nakahara Jun , Välimäki Maritta , Kontio Raija , Anttila Minna 
Published: March 2018

Background: Moral distress occurs when one knows the right thing to do, but institutional constraints make it nearly impossible to pursue the right course of action. Moral distress was found to cause negative feelings, burnout, and/or resignation. Not only external factors such as lack of staff but also internal ones affect moral distress. Moral sensitivity, which is thought of as an advantage of nurses, could effect moral distress, as nurses being unaware of existing ethical problems must feel little distress. Objectives: To examine the impact of moral sensitivity on moral distress among psychiatric nurses, and affirm the hypothesis that nurses with higher moral sensitivity will suffer moral distress more than nurses with less moral sensitivity in two different samples. Ethical consideration: The study obtained ethical approval from the Research Ethics Committee of the Faculty of Medicine at Mie University (# 1111, 20.4.2010), and by the Turku University Ethics Board (29.5.2012). Permissions to undertake the study was obtained from the in two hospital districts and in one city (§ 48/4.10.2012, § 63/4.9.2012, 51/2012 27.8.2012). Informed consent was not formally obtained, because the questionnaire was anonymously reported by the participants who volunteered to answer. The participants responded voluntarily and anonymously. Methods: An anonymous questionnaire containing the Revised Moral Sensitivity Questionnaire and the Moral Distress Scale for Psychiatric nurses was conducted to 997 nurses in 12 hospitals in Japan, and 974 nurses in 10 hospitals in Finland after obtaining of approval by research ethics committees. Data were analyzed using a multi-group structural equation model analysis. Findings: A set of analyses imply that the association of moral sensitivity with moral distress is significant and similar between Japan and Finland, whereas the factor structures of moral sensitivity and moral distress may be partially different. Discussion: The result of this study may indicate that nurses with high moral sensitivity can sense and identify moral problems, but not resolve them. Therefore, supporting nurses to solve ethical problems, not benumbing them, can be important for better nursing care and prevention of nurses’ resignation. Conclusion: Moral sensitivity and moral distress were positively correlated among psychiatric nurses in both Japan and Finland, although the participating nurses from the two countries were different in qualification, age, and cultural background. Nurses with high moral sensitivity suffer from moral distress.