bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of amyloid‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model
Authors: Cheah Irwin K. , Ng Li‐Theng , Ng Li‐Fang , Lam Vanessa Y. , Gruber Jan , Huang Cheryl Y.W. , Goh Fang‐Qin , Lim Keith H.C. , Halliwell Barry 
Published: June 2019

The abnormal accumulation of β‐amyloid peptide (Aβ) is recognized as a central component in the pathogenesis of Alzheimer disease. While many aspects of Aβ‐mediated neurotoxicity remain elusive, Aβ has been associated with numerous underlying pathologies, including oxidative and nitrosative stress, inflammation, metal ion imbalance, mitochondrial dysfunction, and even tau pathology. Ergothioneine (ET), a naturally occurring thiol/thione‐derivative of histidine, has demonstrated antioxidant and neuroprotective properties against various oxidative and neurotoxic stressors. This study investigates ET’s potential to counteract Aβ‐toxicity in transgenic Caenorhabditis elegans overexpressing a human Aβ peptide. The accumulation of Aβ in this model leads to paralysis and premature death. We show that ET dose‐dependently reduces Aβ‐oligomerization and extends the lifespan and healthspan of the nematodes.
The 40 Years’ Evolution of the Chinese Adult and Continuing Education: Where Does it Move Driven by the China Dream?
Authors: Sun Qi , Chang Bo 
Published: June 2019

AbstractThis paper charts the historical and political contexts for the evolution of Chinese adult and continuing education over the past 40 years, focusing on the national adult education reforms and relevant policies, and establishing the national lifelong education system. The progress and transformations of Chinese adult education, including how purposes and roles of adult education have been defined and adjusted to meet the needs, is situated and contextualized in the three main eras, under four Chinese leaderships to clearly understand each ideological foundation and national strategic plan. Reflections on the changes in the Chinese adult education landscape lead to some theoretical understandings of China's ideological shifts and a focus that moved from adult education to vocational and adult education, toward building a lifelong education system, serving the realization of the China Dream, through the current Xi's One Belt and One Road national initiative. Finally, this paper concludes and shares implications.
Building a Learning Society: Perspective From Thailand
Authors: Charungkaittikul Suwithida 
Published: June 2019

AbstractThe concept of lifelong learning is deeply entrenched in Thai culture and tradition. Gradually moving from a primarily agricultural society toward a manufacturing, industrial and service, and society with the goal of becoming a learning society, Thailand needs to offer its people with more lifelong learning opportunities and support to continuously upgrade their lives. This article presents keys aspects regarding lifelong learning, and reviews several Thai nation policies and initiatives for the development of lifelong learning activities toward building a learning society in the Thai context. Case studies presented reflect efforts have been made to help raise local citizens’ awareness to the transformation of communities, cities, and regions into a learning society in Thailand. This article may help provide some developmental guidelines for countries that are in the similar processes of cultivating lifelong learning environment and culture for a sustainable development of a society.
Building a Learning City for Sustainable Development: Spotlight on Beijing, China
Authors: Yuan Dayong , Gui Min , Shen Xinyi 
Published: June 2019

AbstractThe idea of building learning cities is one of the important strategies for implementing lifelong learning in China. It is well accepted through policymaking, research, and practice. This article provides an overview of building a learning city in Beijing. Three cases offer perspectives that explain the structure, policy, and practice of building a learning city: the Community Colleges, an important provider of learning recourses to various learners; the Adult Schools in Daxing, another type of provider from the administrative district offering adult education programs for the local residents; and a learning organization of Shougang, a state owned enterprise that provides learning activities to their employees, updating knowledge and skills for competitiveness and production. It concludes that supported by national and local policies, Beijing has established a system serving as an exemplary model city to practice lifelong learning through and for individuals, institutions, and society at large to achieve the goal of sustainable development for this increasingly developing mega city.
Lifelong Learning on the Go: English Language Mobile Learning in China
Authors: Kang Haijun , Lin Xi 
Published: June 2019

AbstractAs China is playing an active role in the World's politics, economy, and cultural circles, being able to communicate in English has become one of the basic life and work skills and a key for global access and integration. High mobile technology penetration, together with the proliferation of mobile learning applications, have made it possible for Chinese adult learners to learn English on the go. Mobile technology's core features including portability, instant power‐on, on‐demand, and the ability to accommodate multimodal learning styles and preferences are accounted for to describe mobile learning apps’ affordances for lifelong adult learners’ English learning. Four popular English language learning apps, are compared to illustrate how Chinese lifelong adult learners are learning English on the go.
Japanese Social Education and Kominkan Practice: Focus on Residents’ Self‐Learning in Community
Authors: Wang Qianran 
Published: June 2019

AbstractThis article introduces Kominkan and its practice on Japanese social education and how it facilitates Japanese adult education and lifelong learning in local communities. Historically, social education was understood as all education that promotes social development and societal progress. Kominkan, as Japanese social education institutions for citizens, contribute to community development and resolve community issues and problems through self‐determined learning. Nowadays, Kominkan is declining mainly because of administration reasons. However, the need of restoring Kominkan is recognized and reconfirmed in practice. Through elaborating two practices in urban and rural areas in Nagano Prefecture in Japan, it is confirmed that, though Kominkan is under the administration of education bureau, the main idea of Kominkan has always centered on local residents’ self‐learning and encouraging residents’ self‐government on cultivating the community. The practice of Kominkan infuses new insights into empowering communities while promoting lifelong learning and a learning society at local level.
Adoption of Lifelong Learning Policies and Reterritorialization of Adult Education in East Asia
Authors: Choi Seonjoo , Han Soonghee 
Published: June 2019

AbstractThis article, through the sketched history from the mid‐1940s to current, presents the dynamics of adult education in East Asia traditionally called social education, that has survived after lifelong learning has been adopted, assimilated, and dominates the whole pattern of practice. This article argues that the soul of adult education has been unfading in the changing landscape of lifelong learning in East Asia.
pH‐Triggered Conformational Change of Antp‐Based Drug Delivery Platform for Tumor Treatment with Combined Photothermal Therapy and Chemotherapy
Authors: Liang Peiqing , Wang Mohong , Zhang Shixiong , Wang Jiayu , Dai Chunlei , Quan Changyun 
Published: June 2019

AbstractPoor cellular uptake and low therapeutic efficacy of small‐molecule antitumor drugs limit the application of drug delivery systems (DDSs) in cancer therapy. A conformational change of the Antp mimetic peptide (AMP) in tumor microenvironments can greatly increase the cellular uptake as well as control drug release from a DDS. In this study, AMP‐based nanoparticles (AMP‐NPs) conjugated with tyroserleutide (YSL), an immunologically therapeutic tripeptide, are designed to encapsulate doxorubicin (Dox) and indocyanine green (ICG) to improve cellular uptake and cancer therapeutic efficacy by combining chemotherapy with photothermal therapy. In vitro studies verify that AMP‐NPs can control the release of Dox and YSL at different pH values. Cell experiments show that AMP‐NPs can promote the cellular uptake of Dox, and YSL can promote hepatocarcinoma cell (H22) apoptosis through downregulating Bcl‐2 and cyclin D1 expression. In a mouse xenograft model using H22 cells, tumors are ablated when Dox‐ and ICG‐loaded AMP‐NPs are injected with the combination of hyperthermia effect induced by near‐infrared (NIR) laser irradiation and chemotherapy from Dox and YSL. The pH‐, photothermal‐, and glutathione‐responsive AMP‐NPs with a conformational transition strategy can be utilized to synergistically enhance the cancer therapeutic efficacy with few side effects upon NIR laser irradiation.
Biomimetic Shape–Color Double‐Responsive 4D Printing
Authors: Wang Jingchun , Wang Zhenguo , Song Zhengyi , Ren Luquan , Liu Qingping , Ren Lei 
Published: June 2019

AbstractAn emerging technology for producing programmable stimuli‐response materials, 4D printing, is currently confined to shape changing. A new type of 4D printing technology that produces shape–color double‐responsive materials similar to those ubiquitous in biomaterials systems, such as octopuses simultaneously altering their skin color and shape in response to environmental stimuli, is presented. Shape–color double‐responsive composites are prepared through the incorporation of shape‐memory polymer (polylactic acid) and thermochromic pigments. Using the prepared composites and a fused deposition modeling 3D printer, shape–color double‐responsive 4D printing is achieved. The influence of the process parameters and stimulus methods on the characteristics of 4D deformation and discoloration is investigated. Furthermore, by regulating the geometry, process parameters, and stimulus conditions, the speed of shape changing and color transition can be controlled simultaneously. Finally, as a proof‐of‐concept, biomimetic soft robots with shape–color dual responses, including a color‐shifting blooming flower and a camouflaging octopus, are demonstrated. Compared with previously reported 4D printing technologies, this research offers a facile method for manufacturing multiresponsive active composites. The developed shape–color double‐responsive 4D printing method is expected to be helpful for exploring the full potential of 4D printing.
Asymmetric Synthesis of Dihydronaphthalene‐1,4‐Diones via Carbene‐Catalyzed Stereodivergent Reaction
Authors: Zhao Zhifei , Yang Shuang , Lan Shouang , Liu Jinggong , Liu Shuhua , Fang Xinqiang 
Published: June 2019

Abstract2‐Hydroxy‐2,3‐dihydronaphthalene‐1,4‐diones (HDNDs) are ubiquitous in natural products and bioactive molecules, but the rapid asymmetric construction of such scaffolds remains a significant challenge to date. Reported herein is the rapid construction of the above key units via carbene‐catalyzed benzoin reaction. The resolution technique of divergent reaction on racemic mixture (divergent RRM) was employed, affording both isomers of HDNDs in a one‐step fashion. Disubstituted substrates afford products with two contiguous quaternary stereocenters. A series of highly selective transformations on the products can be realized, and mechanistic studies indicate that the benzoin reaction is much faster than the racemization process and the aldol reaction.magnified image
3D anthropometric assessment and perception of male body morphology in relation to physical strength
Authors: Kordsmeyer Tobias L. , Stern Julia , Penke Lars 
Published: June 2019

AbstractObjectivesThe assessment of men's physical strength is an important part of human social perception, for which observers rely on different kinds of cues. However, besides previous studies being limited in considerable ways, as yet there is no comprehensive investigation of a range of somatometric measures in relation to both objectively measured and observer‐perceived physical strength using valid stimuli.MethodsWe examined observer‐perceptions of physical strength from 3D body scans of n = 165 men, the usage and validity of somatometric measures as cues to strength, differences between strength ratings from stimuli presented on computer monitors vs in real‐life size using a projector, and between male and female observers.ResultsA medium‐sized correlation between measured and perceived strength was found, partly mediated by target men's chest‐to‐hip ratio, body density, ankle girth, height, upper arm, and forearm girth. No significant differences between men's and women's strength perceptions or the method of stimuli presentation (computer monitor vs projector) emerged.ConclusionsOur findings suggest that men's physical strength can be assessed with moderate accuracy from 3D body models and that some somatometric measures represent valid cues, which were used by observers, positively predicting both measured and perceived physical strength.
The Football Players’ Health Study at Harvard University: Design and objectives
Authors: Zafonte Ross , Pascual‐Leone Alvaro , Baggish Aaron , Weisskopf Marc G. , Taylor Herman A. , Connor Ann , Baker Jillian , Cohan Sarah , Valdivia Chelsea , Courtney Theodore K. , Cohen I. Glenn , Speizer Frank E. , Nadler Lee M. 
Published: June 2019

AbstractThe Football Players Health Study at Harvard University (FPHS) is a unique transdisciplinary, strategic initiative addressing the challenges of former players’ health after having participated in American style football (ASF). The whole player focused FPHS is designed to deepen understanding of the benefits and risks of participation in ASF, identify risks that are potentially reversible or preventable, and develop interventions or approaches to improve the health and wellbeing of former players. We are recruiting and following a cohort of former professional ASF players who played since 1960 (current n = 3785). At baseline, participants complete a self‐administered standardized questionnaire, including initial reporting of exposure history and physician‐diagnosed health conditions. Additional arms of the initiative are addressing targeted studies, including promising primary, secondary, and tertiary interventions; extensive in‐person clinical phenotyping, and legal and ethical concerns of the play. This paper describes the components of the FPHS studies undertaken and completed thus far, as well as those studies currently underway or planned for the near future. We present our initiatives herein as a potential paradigm of one way to proceed (acknowledging that it is not the only way). We share what we have learned so that it may be useful to others, particularly in regard to trying to make professional sports meet the needs of multiple stakeholders ranging from players to owners, to fans, and possibly even to parents making decisions for their children.
A Triangular Platinum(II) Multinuclear Complex with Cytotoxicity Towards Breast Cancer Stem Cells
Authors: Eskandari Arvin , Kundu Arunangshu , Ghosh Sushobhan , Suntharalingam Kogularamanan 
Published: June 2019

AbstractThe preparation of multinuclear metal complexes offers a route to novel anticancer agents and delivery systems. The potency of a novel triangular multinuclear complex containing three platinum atoms, Pt‐3, towards breast cancer stem cells (CSCs) is reported. The trinuclear platinum(II) complex, Pt‐3 exhibits selective toxicity towards breast CSCs over bulk breast cancer cells and non‐tumorigenic breast cells. Remarkably, Pt‐3 inhibits the formation, size, and viability of mammospheres to a better extent than salinomycin, an established CSC‐potent agent, and cisplatin and carboplatin, clinically used platinum drugs. Mechanism of action studies show that Pt‐3 effectively enters breast CSCs, penetrates the nucleus, induces genomic DNA damage, and prompts caspase‐dependent apoptosis. To the best of our knowledge, Pt‐3 is the first multinuclear platinum complex to selectively kill breast CSCs over other breast cell types.
When Nanozymes Meet Single‐Atom Catalysis
Authors: Jiao Lei , Yan Hongye , Wu Yu , Gu Wenling , Zhu Chengzhou , Du Dan , Lin Yuehe 
Published: June 2019

AbstractNanomaterials with enzyme‐like activities, coined nanozymes, have been researched widely as they offer unparalleled advantages in terms of low cost, superior activity, and high stability. The complex structure and composition of nanozymes has led to extensive investigation of their catalytic sites at an atomic scale, and to an in‐depth understanding of the biocatalysis occurring. Single‐atom catalysts (SACs), characterized by atomically dispersed active sites, have provided opportunities for mimicking metalloprotease and for bridging the gap between natural enzymes and nanozymes. In this Minireview, we illustrate the unique properties of nanozymes and we discuss recent advances in the synthesis, characterization, and applications of SACs. Subsequently, we outline the impressive progress made in single‐atom nanozymes and we discuss their applications in sensing, degradation of organic pollutants, and in therapeutic roles. Finally, we present the major challenges and opportunities remaining for a successful marriage of nanozymes and SACs.
Metal–Organic Framework‐Activated Carbon Composite Materials for the Removal of Ammonia from Contaminated Airstreams
Authors: McHugh Lauren N. , Terracina Angela , Wheatley Paul S. , Buscarino Gianpiero , Smith Martin W. , Morris Russell E. 
Published: June 2019

AbstractMetal–organic frameworks (MOFs) are a class of porous materials that show promise in the removal of toxic industrial chemicals (TICs) from contaminated airstreams, though their development for this application has so far been hindered by issues of water stability and the wide availability and low cost of traditionally used activated carbons. Here a series of three MOF‐activated carbon composite materials with different MOF to carbon ratios are prepared by growing STAM‐17‐OEt crystals inside the commercially available BPL activated carbon. The composite materials display excellent water stability and increased uptake of ammonia gas when compared to unimpregnated carbon. Such properties make these composites very promising in the fields of air purification and personal protective equipment.
In‐situ Chemiluminescence‐Driven Reversible Addition–Fragmentation Chain‐Transfer Photopolymerization
Authors: De Alwis Watuthanthrige Nethmi , Allegrezza Michael L. , Dolan Madison T. , Kloster Alex J. , Kovaliov Marina , Averick Saadyah , Konkolewicz Dominik 
Published: June 2019

AbstractThe power of chemical light generation (chemiluminescence) is used to drive polymerization reactions. A biphasic reaction is developed such that light‐generating reactions are confined to the organic phase and photopolymerization occurs in the aqueous phase. Well‐defined RAFT‐capped polymers are synthesized and the kinetics are shown to be dictated by light generation.
Developing A “Polysulfide‐Phobic” Strategy to Restrain Shuttle Effect in Lithium–Sulfur Batteries
Authors: He Yibo , Qiao Yu , Chang Zhi , Cao Xin , Jia Min , He Ping , Zhou Haoshen 
Published: June 2019

AbstractInspired by hydrophobic interface, a novel design of “polysulfide‐phobic” interface was proposed and developed to restrain shuttle effect in lithium–sulfur batteries. Two‐dimensional VOPO4 sheets with adequate active sites were employed to immobilize the polysulfides through the formation of a V−S bond. Moreover, owing to the intrinsic Coulomb repulsion between polysulfide anions, the surface anchored with polysulfides can be further evolved into a “polysulfide‐phobic” interface, which was demonstrated by the advanced time/space‐resolved operando Raman evidences. In particular, by introducing the “polysulfide‐phobic” surface design into separator fabrication, the lithium–sulfur battery performed a superior long‐term cycling stability. This work expands a novel strategy to build a “polysulfide‐phobic” surface by “self‐defense” mechanism for suppressing polysulfides shuttle, which provides new insights and opportunities to develop advanced lithium–sulfur batteries.
Asymmetric Hydrocyanation of Alkenes without HCN
Authors: Li Xiuxiu , You Cai , Yang Jiaxin , Li Shuailong , Zhang Dequan , Lv Hui , Zhang Xumu 
Published: June 2019

AbstractA general and efficient rhodium‐catalyzed asymmetric cyanide‐free hydrocyanation of alkenes has been developed. Based on the asymmetric hydroformylation/condensation/aza‐Cope elimination sequences, a broad scope of substrates including mono‐substituted, 1,2‐, and 1,1‐disubstituted alkenes (involving natural product R‐ and S‐limonene) were employed, and a series of valuable chiral nitriles are prepared with high yields (up to 95 %) and enantioselectivities (up to 98 % ee). Notably, the critical factor to achieve high enantioseletivies is the addition of catalytic amount of benzoic acid. This novel methodology provides an efficient and concise synthetic route to the intermediate of vildagliptin and anagliptin.
Physiochemical properties and novel biological applications of Callistemon viminalis‐mediated α‐Cr2O3 nanoparticles
Authors: Hassan Dilawar , Khalil Ali Talha , Solangi Amber Rehana , El‐Mallul Ahmed , Shinwari Zabta Khan , Maaza Malik 
Published: June 2019

We report an eco‐friendly synthesis of α‐Cr2O3 nanoparticles (NPs) using Callistemon viminalis (Bottle Brush) flower extracts as an efficient reducing and capping agent. NPs of sizes 15 nm and 17 nm were synthesized by annealing them at 400°C and 500°C, respectively, which were characterized by X‐ray diffraction, UV–Vis, Fourier transform‐infrared, high‐resolution‐transmission electron microscopy/scanning electron microscopy, SAED, energy‐dispersive X‐ray spectroscopy and SQUID. Microplate‐based assay was used for examining antibacterial potential against 12 pathogenic bacterial strains, and their minimum inhibitory concentrations were calculated. MTT cytotoxic assay was accomplished on Leishmania tropica amastigotes and promastigotes, which revealed IC50 values of 44 μg/ml and 10.56 μg/ml, respectively. An IC50 value of 46.32 μg/ml was obtained for HepG2 cancer cells. Enzyme inhibition studies indicated good acetylcholinesterase, moderate butyrylcholinesterase and low alpha‐glucosidase inhibition. Hemolytic assay indicated hemocompatibility at low concentration. In addition, good DPPH radical scavenging and moderate reducing power and total antioxidant potential was revealed by α‐Cr2O3 NPs.
A lithium‐organic framework as a fluorescent sensor for detecting aluminum (III) ion
Authors: Feng Lijuan , Ren Guojian , Ding Shunan , Wang Fuxiang , Yang Weiting , Liang Zhiqiang , Pan Qinhe 
Published: June 2019

Due to the low coordination number and the relatively weak coordination ability, it is a great challenge to introduce Li+ into the construction of metal–organic frameworks (MOFs). Here, one Li‐based metal–organic framework (Li‐MOF), [Li4L(DMF)2]n (HNU‐31), is constructed by the assembly of LiNO3 and 5‐(bis(4‐carboxybenzyl)amino)isophthalic acid (H4L) ligand, which possesses a 3D framework, and can be serve as a luminescent sensor for detecting Al3+ ion with the detection limit of 4 × 10−6 M.