bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Radiographic Outcomes of a Posteriorly Augmented Glenoid Component in Anatomic Total Shoulder Arthroplasty for Primary Osteoarthritis with Posterior Glenoid Bone Loss
Authors: Ho Jason C. , Amini Michael H. , Entezari Vahid , Jun Bong Jae , Alolabi Bashar , Ricchetti Eric T. , Iannotti Joseph P. 
Published: November 2018

Background:The primary objectives of this study were to evaluate the ability of a posteriorly stepped augmented glenoid component, used in patients with primary glenohumeral osteoarthritis with B2 or B3 glenoid morphology, to correct preoperative retroversion and humeral head subluxation and to identify factors associated with radiographic radiolucency and patient-reported clinical outcomes.Methods:We identified 71 shoulders with B2 or B3 glenoid morphology that underwent anatomic total shoulder arthroplasty with use of a posteriorly stepped augmented glenoid component and with a preoperative 3-dimensional computed tomography (3D-CT) scan and a minimum of 2 years of clinical and radiographic follow-up. The Penn Shoulder Score (PSS), shoulder range of motion, glenoid center-peg osteolysis, and postoperative version and humeral head subluxation were the main outcome variables of interest.Results:Follow-up was a median of 2.4 years (range, 1.9 to 5.7 years); the mean patient age at treatment was 65 ± 7 years (range, 51 to 80 years). PSS, range of motion, humeral head centering, and glenoid version were significantly improved among all patients (p < 0.0001). Patients with persistent posterior subluxation of the humeral head postoperatively had worse preoperative fatty infiltration of the teres minor and greater postoperative component retroversion (p < 0.05). Patients with center-peg osteolysis had more preoperative joint-line medialization and posterior glenoid bone loss (p < 0.05). Patients with more preoperative humeral head posterior subluxation had a lower PSS, adjusting for confounders (p < 0.05).Conclusions:Posteriorly stepped augmented glenoid components can improve pathologic retroversion and posterior subluxation of the humeral head in B2 and B3 glenoids, with significant improvements found in clinical outcome scores at a minimum of 2 years of follow-up in the vast majority of patients.Level of Evidence:TherapeuticLevel IV. See Instructions for Authors for a complete description of levels of evidence.
Safety of Overlapping Inpatient Orthopaedic Surgery
Authors: Dy Christopher J. , Osei Daniel A. , Maak Travis G. , Gottschalk Michael B. , Zhang Alan L. , Maloney Michael D. , Presson Angela P. , O’Keefe Regis J. 
Published: November 2018

Background:
Although overlapping surgery is used to maximize efficiency, more empirical data are needed to guide patient safety. We conducted a retrospective cohort study to evaluate the safety of overlapping inpatient orthopaedic surgery, as judged by the occurrence of perioperative complications.

Methods:
All inpatient orthopaedic surgical procedures performed at 5 academic institutions from January 1, 2015, to December 31, 2015, were included. Overlapping surgery was defined as 2 skin incisions open simultaneously for 1 surgeon. In comparing patients who underwent overlapping surgery with those who underwent non-overlapping surgery, the primary outcome was the occurrence of a perioperative complication within 30 days of the surgical procedure, and secondary outcomes included all-cause 30-day readmission, length of stay, and mortality. To determine if there was an association between overlapping surgery and a perioperative complication, we tested for non-inferiority of overlapping surgery, assuming a null hypothesis of an increased risk of 50%. We used an inverse probability of treatment weighted regression model adjusted for institution, procedure type, demographic characteristics (age, sex, race, comorbidities), admission type, admission severity of illness, and clustering by surgeon.

Results:
Among 14,135 cases, the frequency of overlapping surgery was 40%. The frequencies of perioperative complications were 1% in the overlapping surgery group and 2% in the non-overlapping surgery group. The overlapping surgery group was non-inferior to the non-overlapping surgery group (odds ratio [OR], 0.61 [90% confidence interval (CI), 0.45 to 0.83]; p < 0.001), with reduced odds of perioperative complications (OR, 0.61 [95% CI, 0.43 to 0.88]; p = 0.009). For secondary outcomes, there was a significantly lower chance of all-cause 30-day readmission in the overlapping surgery group (OR, 0.67 [95% CI, 0.52 to 0.87]; p = 0.003) and shorter length of stay (eβ, 0.94 [95% CI, 0.89 to 0.99]; p = 0.012). There was no difference in mortality.

Conclusions:
Our results suggest that overlapping inpatient orthopaedic surgery does not introduce additional perioperative risk for the complications that we evaluated. The suitability of this practice should be determined by individual surgeons on a case-by-case basis with appropriate informed consent.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
The Michigan Arthroplasty Registry Collaborative Quality Initiative Experience: Improving the Quality of Care in Michigan
Authors: Hughes Richard E. , Zheng Huiyong , Igrisan Rochelle M. , Cowen Mark E. , Markel David C. , Hallstrom Brian R. 
Published: November 2018

Abstract:
The Michigan Arthroplasty Registry Collaborative Quality Initiative (MARCQI) is a regional quality improvement effort that is focused on hip and knee arthroplasty. From its inception in 2012, MARCQI has grown to include data from 66 hospitals and surgery centers, and contains over 209,000 fully abstracted cases in its database. Using high-quality risk-standardized outcomes data, MARCQI drives quality improvement through a collaborative and nonpunitive structure. Quality improvement initiatives have included transfusion reduction, infection prevention, venous thromboembolism reduction, and reduction of discharge to nursing homes. In addition, MARCQI focuses on postmarket surveillance of implants by computing revision-risk estimates based on the cases that were registered prior to the end of 2016. This paper describes the impact of MARCQI on the quality of hip and knee arthroplasty care in the state of Michigan since its inception in 2012, and it briefly summarizes the recently released 5-year report.
Open Reduction and Tunneled Suspensory Device Fixation Compared with Nonoperative Treatment for Type-III and Type-IV Acromioclavicular Joint Dislocations
Authors: Murray Iain R. , Robinson Patrick G. , Goudie Ewan B. , Duckworth Andrew D. , Clark Kathryn , Robinson C. Michael 
Published: November 2018

Background:
Nonoperative management of complete acromioclavicular (AC) joint dislocation has yielded reasonable results, although patients may report dissatisfaction with the outcome. The purpose of this prospective, randomized, controlled trial was to compare patient outcome following nonoperative care versus operative treatment with open reduction and tunneled suspension device (ORTSD) fixation for acute, type-III or IV disruptions of the AC joint.

Methods:
Sixty patients aged 16 to 35 years with an acute type-III or IV disruption of the AC joint were randomized to receive ORTSD fixation or nonoperative treatment, following a power analysis to determine sample size. Functional outcomes were assessed with use of the Disabilities of the Arm, Shoulder and Hand (DASH) as the primary outcome measure and the Oxford Shoulder Scores (OSS) and Short Form (SF-12) as secondary outcome measures at 6 weeks, 3 months, 6 months, and 1 year after treatment. Reduction was evaluated with use of radiographs. Any complications were noted at each assessment. The economic implication of each treatment was evaluated.

Results:
ORTSD and nonoperative groups were similar with regard to demographics at baseline. The mean degree of radiographic displacement was significantly less in patients following ORTSD fixation (1.75 mm) compared with patients who received nonoperative treatment (10.61 mm, p < 0.0001). At 1 year postoperatively, the mean DASH score was 4.67 in the nonoperative treatment group and 5.63 in the ORTSD group, and the mean OSS was 45.72 and 45.63, respectively. Patients managed with ORTSD fixation had inferior DASH scores at 6 weeks (p < 0.01). There were 5 patients who experienced failed nonoperative treatment and subsequently underwent a surgical procedure. ORTSD fixation (£3,359.73) was associated with significantly higher costs than nonoperative treatment (£796.22, p < 0.0001).

Conclusions:
ORTSD fixation confers no functional benefit over nonoperative treatment at 1 year following type-III or IV disruptions of the AC joint. Although patients managed nonoperatively generally recovered faster, a substantial group of patients remained dissatisfied following nonoperative treatment and required delayed surgical reconstruction. We were unable to identify any demographic or injury-related factors that predicted a poorer outcome in these patients.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
A Short Synthesis of the Plant Alkaloid 4-Methyl-2,6-naphthyridine
Authors: Kamlah Alexandra , Bracher Franz 
Published: November 2018

:
A new synthesis of the 2,6-naphthyridine alkaloid 4-methyl-2,6-naphthyridine from Antirrhinum
majus has been developed. Key steps are a regioselective oxidation of 3-bromo-4,5-
dimethylpyridine to the corresponding 4-formyl derivative, and the annulation of the second pyridine
ring by Suzuki-Miyaura cross-coupling using (E)-2-ethoxyvinylboronic acid pinacol ester as a masked
acetaldehyde equivalent. This protocol gives the alkaloid in four steps starting from commercially
available 3,4-dimethylpyridine in 15% overall yield. This annulation protocol should be useful for the
synthesis of other condensed pyridines as well.
The Structure of MT189-Tubulin Complex Provides Insights into Drug Design
Authors: Li Zhongping , Ma Lingling , Wu Chengyong , Meng Tao , Ma Lanping , Zheng Wenyue , Yu Yamei , Chen Qiang , Yang Jinliang , Shen Jingkang 
Published: November 2018

Background:
Drugs that interfere with microtubule dynamics are used widely in cancer
chemotherapy. Microtubules are composed of αβ-tubulin heterodimers, and the colchicine binding
site of tubulin is an important pocket for designing tubulin polymerization inhibitors. We have
previously designed and synthesized a series of colchicine binding site inhibitors (CBSIs). However,
these compounds showed no anticancer activity in vivo. Then, we have used a deconstruction
approach to obtain a new derivative MT189, which showed in vivo anticancer activity.

Methods:
We crystallized a protein complex including two tubulins, one stathmin-like domain of
RB3 and one tubulin tyrosine ligase, and soaked MT189 into the crystals. We collected the
diffraction data and determined the tubulin-MT189 structure to 2.8 Å.

Results:
Here, we report the crystal structure of tubulin complexed with MT189, elucidate how the
small-molecular agent binds to tubulin and inhibits microtubule assembly, and explain previous
results of the structure-activity-relationship studies.

Conclusion:
The tubulin-MT189 complex structure reveals the interactions between this agent and
tubulin and provides insights into the design of new derivatives targeting the colchicine binding site.
Quinazolin-4-One: A Varsatile Molecule
Authors: Amrutkar Rakesh D. , Amrutkar Sunil V. , Ranawat Mahendrasing S. 
Published: November 2018

Background:Quinazolines and quinazolinones constitute a major class of biologically active molecules both from natural and synthetic sources. We will limit this review to compounds possessing the 4(3H)-quinazolinone skeleton, which is found in compounds displaying significant biological and pharmacological properties. The molecular design of potential lead compound is still a key line of approach for the discovery and development of new chemical entities. A combination of two or more chemical moieties into one is a common approach of operation and this can most likely result in the improvement of pharmacological activity and removal of unwanted side effects.Methods:We undertake search for peer-reviewed and research literature on quinazolinone moiety using different tools of literature survey. The quality of superior papers was assess using standard tools. The distinctiveness of screened papers was shorted and high-quality content was reorganiz and written in own language.Results:The review will be expressed in two main sections, the first section will be related to synthetic procedures and the second section includes the biological importance of Quinazoline derivatives. Total hundred (100) to one hundred and ten (110) research papers ware searched. Out of these, seventy-eight papers were included in the review, the majority of research papers were from international journals. Fifty fours papers defined the different synthetic schemes considering the general strategies using orthosubstituted anilines such as 2-aminobenzoic acid (anthranilic acid) and its analogues, or isatoic anhydride as starting materials, which are condensed with acid chlorides, imidates or aldehydes. Microwave irradiation was also proven to be very useful to improve the yields, and in particular, it has been successfully applied to the Niementowski procedure involving the fusion of anthranilic acid with formamide. The remaining part of the review focuses on biological importance of the 4(3H)-quinazolinone scaffold as therapeutic agents and a broad range of activities like antibacterial, antifungal, antiviral, anticonvulsant, antitumor, antihypertensive, analgesic and anti-inflammatory agents has been highlighted.Conclusion:The present review focuses on simplified, efficient and widespread literature of the methods of synthesis and diverse pharmacological activities of quinazoline and its derivatives have been highlighted.
Bioactive Compounds and Biological Activity of Croton Species (Euphorbiaceae): An Overview
Authors: Bezerra Fernanda W.F. , do N. Bezerra Priscila , de Oliveira Mozaniel S. , da Costa Wanessa A. , Ferreira Gracialda C. , de Carvalho Raul N. 
Published: November 2018

Background:
Croton species are widely spread around the world, and present a varied
chemical composition distributed in many classes of secondary metabolites, such as terpenoides, alkaloids,
phenolic compounds and phenylpropanoids. These compounds can be obtained by different extraction
methods, and more recently, with supercritical fluids. The crude and isolated extracts may have
applications due to their biological activities in animals and humans.

Methods:
The text was written based on literature data from 1996 onwards.

Results:
The research showed in a concise way the botanical and taxonomic aspects of Croton and the
success of its application is in studies related to the biological activities of the plant parts. It was also
related to the chemical composition of its extracts and isolated compounds, obtained by many methods.

Conclusion:
In summary, the review feature studies reported the use of extracts and isolated Croton
compounds due to their biological effects with antioxidant, antimicrobial, anti-inflammatory, neuroprotective,
antitumor, anticancer, cytotoxic, insecticidal and allelopathic activities, with potential application
in food, cosmetics, pharmaceuticals, and agrochemicals products.
Green Synthesis of Silver Nanoparticles from Aqueous Leaf Extract of 'Selaginella bryopteris' and Elucidation of its Antimicrobial Activity
Authors: Yadav Varsha , Kapoor Neha , Ghorai Soma M. , Pradeep  
Published: November 2018

Background:
Biosynthesis of nanoparticles from aqueous leaf extract of ‘Selaginella bryopteris’
is a green chemistry approach and is considered to be one of the most efficient methods as it is
devoid of toxic chemicals as well as provides natural capping agents for the stabilization of synthesized
nanoparticles. ‘S.bryopteris’ also known as ‘Sanjeevani’ (in India), is thought to be prospective natural
resource that possesses extraordinary pharmaceutical potential.

Objective:
S. bryopteris is exclusively native to India and has already been known for its expression of
stress-associated genes and high levels of protective metabolites of sugars, phenolic compounds, and
polyols. Its potential as an antibacterial agent is being elucidated.

Methods:
Different leaf extract volumes, silver nitrate (AgNO3) concentrations, and reaction time were
investigated separately and the optimal conditions for the synthesis of AgNPs were suggested. The resulting
AgNPs were characterized by various techniques like Ultraviolet-Visible (UV-Vis) Spectroscopy,
Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and XRay
Diffraction (XRD). Antibacterial assays were carried out by using both agar disk and well diffusion
method.

Results:
The AgNPs synthesized in this process were found to have efficient antimicrobial activity
against both Gram-positive as well as Gram-negative bacteria. The antibacterial efficacy of S. bryopteris
was consciously tried on uropathogenic Escherichia coli (Gram-negative bacteria) and Bacillus
megaterium (Gram-positive bacteria) which have the self-limiting food poisoning potential along with
opportunistic uropathogenic bacterial strains namely Proteus mirabilis (Gram-negative bacteria) and a
non-pathogenic Micrococcus luteus (Gram-positive bacteria) for comparison.

Conclusion:
S. bryopteris mediated silver nanoparticles’ synthesis is attempted for being cost-effective,
eco-friendly and safe for human therapeutics.
Drug in Adhesive Transdermal Formulation of Valsartan and Nifedipine: Pharmacokinetics and Pharmacodynamics in Rats
Authors: Sood Jatin , Sapra Bharti , Tiwary Ashok K. 
Published: November 2018

Background:
The increasing complications associated with hypertension often
require a combination of two or more drugs acting through different routes to counter the
elevated blood pressure.

Objective:
The present investigation envisaged at preparing and evaluating a transdermal
formulation containing gelled microemulsion drug in adhesive (DIA) patch for simultaneous
systemic delivery of valsartan and nifedipine aimed at effective management of
hypertension.

Methods:
An optimized microemulsion was prepared by using Captex® 500 (7.34% w/w),
Capmul® MCM (4.24% w/w), Acrysol EL 135 (24.43% w/w), Transcutol P® (5% w/w)
and water (58.9% w/w). Gelling was contributed by polyvinylpyrrolidone K 90F and
polyethyleneimine where the latter also conferred skin adhesion properties to the patch.
DIA patches were evaluated for in vitro drug release as well as in vivo pharmacokinetics
and pharmacodynamics in rats.

Results:
In vitro permeation of nifedipine or valsartan from the selected DIA patch was
10.67-fold and 1.25-fold higher as compared to their aqueous dispersions. The relative
bioavailability of nifedipine was 1.34 and that of valsartan was 2.18 from this DIA patch
with respect to the oral administration of their aqueous suspension.

Conclusion:
Transdermal delivery of either drug alone was not effective in reducing
methyl prednisolone acetate-induced hypertension, whereas, simultaneous transdermal
delivery of both drugs from DIA patch effectively maintained systolic blood pressure at a
normal level in these rats for 20 h.
A Detailed Survey and Comparative Study of Cooperative Caching Methods for Mobile Ad Hoc Networks
Authors: Jain Devendra Kumar , Sharma Sanjay , Yadav Shashank , Singh Jitendra 
Published: November 2018

:Mobile Ad Hoc Networks (MANETs) are networks that enable server and clients to impart without any settled foundation. MANET is a quickly developing region of research as it discovers use in different applications. In MANETs, network parceling and the fizzling of a mobile node because of weariness of their battery power can significantly diminish data accessibility. Data caching on the client is generally observed as a successful answer for enhancing data availability. Specifically, cooperative caching based on information sharing and coordination of cached data item among numerous clients is much time-consuming. Various cooperative caching plans have been proposed in the ongoing years. This paper examines the highlights for outlining a good cooperative cache management, and it overviews the current cooperative caching scheme. The paper likewise gives a correlation of the cooperative caching scheme and examines open doors for future research work.
PARTISIPASI MASYARAKAT DALAM MITIGASI BENCANA DI KAWASAN RAWAN BENCANA III GUNUNG MERAPI DESA MRANGGEN
Authors: Susanti Evi , Khotimah Nurul 
Published: November 2018

AbstrakPenelitian ini bertujuan mengetahui: (1) mitigasi bencana yang tepat di Kawasan Rawan Bencana (KRB III) Gunung Merapi Desa Mranggen, 2) tingkat partisipasi masyarakat dalam mitigasi bencana. Penelitian ini merupakan penelitian deskriptif. Populasi dalam penelitian ini adalah seluruh Kepala Keluarga di Desa Mranggen sejumlah 1291 KK. Sampel diambil secara stratified random sampling. Pengumpulan data dilakukan dengan observasi, dokumentasi dan wawancara. Analisis data secara deskriptif menggunakan tabel frekuensi. Hasil penelitian menunjukkan (1) (a) mitigasi struktural berupa pembangunan Check dam, Sabo dam, Operit, Jembatan Gantung, Tanggul/Bronjong, Talud/Drainase, dan Jalur Evakuasi. (b) mitigasi nonstruktural meliputi penyusunan Standar Operasional Prosedur Penanggulangan Bencana Gunung Merapi, Prosedur Tetap Penanggulangan Bencana (Protap PB), Prosedur Evakuasi, Program Sister Village, Peta KRB, OPRB (Organisasi Pengurangan Risiko Bencana), Penghutanan, Sosialisasi PB dan Alat Komunikasi HT (Handy Talky). (2) Tingkat partisipasi masyarakat dalam mitigasi bencana menunjukkan bahwa rata-rata skor nilai keseluruhan responden pada masing-masing tahapan partisipasi 22,64 atau 36% tergolong dalam tingkatan sedang. Kata kunci: mitigasi bencana, Gunung Merapi, partisipasi masyarakat, Kawasan Rawan Bencana
ANALISIS RISIKO BENCANA ERUPSI GUNUNGAPI SUNDORO DI KECAMATAN NGADIREJO KABUPATEN TEMANGGUNG
Authors: Hasib Akhmad Ganang , Sumunar Dyah Respati Suryo 
Published: November 2018

AbstrakPenelitian ini bertujuan mengetahui: (1) pengaruh faktor bahaya, kerentanan, dan kapasitas, (2) tingkat dan sebaran risiko bencana erupsi Gunungapi Sundoro. Penelitian ini merupakan penelitian survey deskriptif dengan pendekatan kuantitatif. Populasi meliputi seluruh wilayah Kecamatan Ngadirejo dengan pengambilan sampel secara purposive berdasarkan Peta KRB Gunungapi Sundoro. Pengumpulan data dengan wawancara dan observasi untuk memperoleh data kapasitas; dokumentasi dan interpretasi untuk memperoleh data kerentanan dan bahaya. Analisis data dengan overlay, scoring, dan deskriptif. Hasil penelitian menunjukkan (1) Faktor bahaya, kerentanan, dan kapasitas memiliki pengaruh yang bervariasi terhadap terjadinya bencana. (2) Tingkat dan sebaran risiko bencana erupsi dibagi menjadi sedang, rendah, dan sangat rendah. Tingkat risiko sedang mendominasi sebagian wilayah Desa Katekan dan Giripurno. Tingkat risiko rendah mendominasi sebagian besar wilayah Katekan, Tegalrejo, dan Giripurno. Tingkat risiko sangat rendah mendominasi sebagian Purbosari, Tegalrejo, dan Banjarsari. Tingkat risiko sangat rendah di wilayah Medari, Campursari, Manggong, Gondangwinangun, Karanggedong, Kataan, Ngadirejo, Gandu Wetan, Munggangsari, Gejagan, Pringapus, dan Mangunsari. Kata kunci: Erupsi Gunungapi Sundoro, Risiko Bencana, Kecamatan Ngadirejo