bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haploidentical transplantation using posttransplant cyclophosphamide as GVHD prophylaxis in patients over age 70
Authors: Imus Philip H. , Tsai Hua-Ling , Luznik Leo , Fuchs Ephraim J. , Huff Carol Ann , Gladstone Douglas E. , Lowery Patrick , Ambinder Richard F. , Borrello Ivan M. , Swinnen Lode J. , Wagner-Johnston Nina , Gocke Christian B. , Ali Syed Abbas , Bolaños-Meade F. Javier , Varadhan Ravi , Jones Richard J. 
Published: September 2019

AbstractHematologic malignancies in older people are unlikely to be cured with chemotherapy alone. Advances in allogeneic blood or marrow transplantation (alloBMT), especially nonmyeloablative (NMA) conditioning and the use of haploidentical donors, now make this therapy available to older people; however, long-term outcomes and predictors of success are unclear. We reviewed the outcomes of 93 consecutive patients aged 70 and older (median, 72; range, 70-78), who underwent haploidentical BMT at Johns Hopkins Hospital between 1 September 2009 and 1 April 2018. All patients received NMA conditioning and posttransplantation cyclophosphamide (PTCy) as graft-versus-host disease (GVHD) prophylaxis. The 2-year overall survival was 53%, and 2-year event-free survival was 43%. The 180-day cumulative incidence (CuI) of nonrelapse mortality (NRM) was 14%, and the 2-year CuI was 27%. The 2-year CuI of relapse was 30%. Of 78 patients who were alive and had their weight recorded on day 180, weight loss predicted subsequent NRM (subdistribution hazard ratio, 1.0; 95% CI, 1-1.13; P = .048). In conclusion, haploidentical BMT with PTCy is feasible and relatively safe in septuagenarians. Although early, 6-month NRM was relatively low at 14%, but overall NRM continued to climb to 27% at 2 years, at least in part because of late deaths that appeared to be somewhat age related. Further studies to elucidate predictors of NRM are warranted.
What are the effects of control of mosquitoes and other nematoceran Diptera using the microbial agent Bacillus thuringiensis israelensis (Bti) on aquatic and terrestrial ecosystems? A systematic review protocol
Authors: Land Magnus , Bundschuh Mirco , Hopkins Richard J. , Poulin Brigitte , McKie Brendan G. 
Published: September 2019

Abstract
Background
The bacterium Bacillus thuringiensis serovar israelensis (Bti) is used in many countries as a biological larvicide to control dipteran insects of the suborder Nematocera, especially mosquitoes and black flies. Bti is generally accepted to be target-specific and efficient, with low potential for development of resistance among the target species. However, even though Bti may have minimal direct effects on non-target organisms, it might potentially be associated with knock-on effects on food webs and other ecosystem properties, including biodiversity and ecosystem functioning. Evidence from previous research is mixed, with some finding no evidence for indirect effects on biodiversity and ecosystem-level properties, but others indicating that such effects are possible. The fact that many studies have been conducted by organisations coordinating the control programs, and that many of those studies have been published outside peer reviewed scientific journals, highlights the challenges for decision makers and others to assess the results of the existing studies. In this protocol we outline how we aim to systematically and transparently synthesise all available evidence in a forthcoming systematic review.

Methods
We will use six bibliographic databases/platforms and the online search engines Google and Google Scholar in searches for literature. Searches will also be made on specialist websites. We will screen the search results for eligibility in stage one based on title and abstract, and in stage two based on the full text of the material. At stage one, after testing and clarifying the eligibility criteria, two reviewers will split and single screen the search results. At stage two the articles will be screened independently by two reviewers. We have developed a preliminary critical appraisal tool that will be used as basis for assessing study validity. Each study will be critically appraised independently by two reviewers. Disagreements will be reconciled through discussions seeking to reach consensus. It is unclear whether a quantitative synthesis based on meta-analysis will be feasible. A narrative synthesis will include descriptive statistics outlining the evidence base in terms of bibliographic information and study metadata. A narrative synthesis table in the form of an Excel spreadsheet will be provided.
Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish
Authors: Ding Yonghe , Dvornikov Alexey V. , Ma Xiao , Zhang Hong , Wang Yong , Lowerison Matthew , Packard Rene R. , Wang Lei , Chen Jun , Zhang Yuji , Hsiai Tzung , Lin Xueying , Xu Xiaolei 
Published: September 2019

ABSTRACT
The adult zebrafish is an emerging vertebrate model for studying human cardiomyopathies; however, whether the simple zebrafish heart can model different subtypes of cardiomyopathies, such as dilated cardiomyopathy (DCM), remains elusive. Here, we generated and characterized an inherited DCM model in adult zebrafish and used this model to search for therapeutic strategies. We employed transcription activator-like effector nuclease (TALEN) genome editing technology to generate frame-shift mutants for the zebrafish ortholog of human BCL2-associated athanogene 3 (BAG3), an established DCM-causative gene. As in mammals, the zebrafish bag3 homozygous mutant (bag3e2/e2) exhibited aberrant proteostasis, as indicated by impaired autophagy flux and elevated ubiquitinated protein aggregation. Through comprehensive phenotyping analysis of the mutant, we identified phenotypic traits that resembled DCM phenotypes in mammals, including cardiac chamber enlargement, reduced ejection fraction characterized by increased end-systolic volume/body weight (ESV/BW), and reduced contractile myofibril activation kinetics. Nonbiased transcriptome analysis identified the hyperactivation of the mechanistic target of rapamycin (mTOR) signaling in bag3e2/e2 mutant hearts. Further genetic studies showed that mtorxu015/+, an mTOR haploinsufficiency mutant, repaired abnormal proteostasis, improved cardiac function and rescued the survival of the bag3e2/e2 mutant. This study established the bag3e2/e2 mutant as a DCM model in adult zebrafish and suggested mtor as a candidate therapeutic target gene for BAG3 cardiomyopathy.
Workshop on Micro-Rheology - Characterisation of the mechanical properties of food systems at the micrometer length scale
Authors: Paques Marcel , Hamer Rob 
Published: September 2019

Summary
The heterogeneity of food microstructure on mesoscopic scale plays a crucial role in the perception of food texture. Micro-rheology (the study of mechanical properties on a micrometer length scale) opens new perspectives for the study of “structure – function relationships” of food systems, and overcomes current limitations of instrumental approaches that are generally accepted.
Physica Advanced Peltier System PTD 150 (pat. pent.). Making the Temperature Control with a Peltier System Accurate
Authors: Läuger Jörg , Raffer Gerhard 
Published: September 2019

AbstractA new Peltier system is introduced which offers new dimensions in temperature precision for parallel-plate and cone-and-plate measuring geometries in the temperature range from −30°C to +130°C. The use of an additional actively Peltier controlled hood (pat. pent.) reduces the temperature gradient across the sample to insignificant levels. The design allows easy access for sample loading and trimming as well as the use of inert gas or a solvent trap if necessary.
Different vitamin D status in common multiorgan autoimmune disease patients
Authors: Xie Erfu , Zhao Zhongjian , Yan Chengjing , Zhang Yiting , Zhang Qiaodi , Pan Shiyang 
Published: September 2019

Abstract

Background
Vitamin D plays a key role in calcium homeostasis and contributes to the regulation of the immune system. Furthermore, vitamin D deficiency has been reported to be associated with autoimmune diseases (AIDs), especially with multiorgan AIDs. Various multiorgan AIDs may be different based on the vitamin D status. This study aims to investigate the serum 25-hydroxyvitamin D (25(OH)D) levels in patients with different common multiorgan AIDs.

Methods
A total of 295 patients with multiorgan AIDs treated in our hospital from January 2012 to September 2018 were recruited, including 137 cases of rheumatoid arthritis (RA), 85 cases of systemic lupus erythematosus (SLE), 32 cases of Sjögren’s syndrome (SS) and 41 cases of mixed connective tissue disease (MCTD); 47 apparently healthy individuals were also recruited as controls. The serum 25(OH)D levels in patients with different multiorgan AIDs were measured with Roche electrochemiluminescence immunoassay and statistically analyzed the proportion of patients with normal, insufficiency and deficiency in 25(OH)D levels in different multiorgan diseases. The 25(OH)D levels of different multiorgan AID groups and healthy controls were also compared.

Results
Incidences of 25(OH)D deficiency in the RA, SLE, SS and MCTD groups were 21.2%, 35.3%, 25.0% and 22.0%, respectively, with significant inter-group differences (p < 0.05). The incidence in the SLE group was higher than in the RA, SS and MCTD groups, indicating severe 25(OH)D deficiency in patients with SLE. Significant inter-group differences (p < 0.05) were detected in the serum 25(OH)D levels in different multiorgan AID groups and in the healthy control group. Further pairwise comparison found a significantly higher level of 25(OH)D in the healthy control group than in the SLE, SS, RA and MCTD groups (p < 0.05). Moreover, the 25(OH)D status in the SLE group was significantly lower than that in the SLE, SS, RA and MCTD groups (p < 0.05).

Conclusions
Serum 25(OH)D deficiency and a low 25(OH)D status are commonly seen in patients with different multiorgan AIDs compared to healthy controls, warranting vitamin D supplementation. Severe 25(OH)D deficiency and a lower 25(OH)D status were found in patients with SLE.
Impact of graphene/graphene oxide on the mechanical properties of cellulose acetate membrane and promising natural seawater desalination
Authors: Ismail Nahla , El-Gendi Ayman , Essawy Hisham , El-Din Lara Nezam , Abed Kamal , Ahmed Awad 
Published: September 2019

Abstract
New formulations of cellulose acetate (CA) membrane with graphene (G)/graphene oxide (GO) are suggested and investigated in the present work. This study is intended to find a wide range of conditions for fabricating CA membranes in the presence of some additions of graphene (G), and graphene oxide (GO). The membrane is prepared by phase inversion process. Microscopic investigations for graphene (G), graphene oxide (GO), and prepared membrane were performed by high-resolution transmission electron microscope (HRTEM) and scanning electron microscopy (SEM). The mechanical properties of prepared membranes are determined and evaluated. Permeation tests were performed using natural seawater and simulated seawater to check the prepared membrane performance. The results presented that the permeate flux of M25% CA membranes containing 0.01 wt.% G is the highest flux (57–74 l/m2 h) compared with the neat CA membrane, and the 0.01 wt.% GO-based membranes, while the GO-based membranes were comparable as the neat CA membrane at operating pressures (30–35 bar) and with a feed of 35 g/l NaCl solution. The results showed a remarkable salt rejection of simulated seawater of 95%, and natural seawater with a feed from the Mediterranean Sea displayed 90% salt rejection and accepted pure water flux as well.
ONLINE BUYING AND SELLING TRANSACTIONS UNDER INTERNATIONAL PRIVATE LAW
Authors: Lubis Muhammad Ikhsan 
Published: September 2019

Development of business transactions especially buying and selling has globally impact to daily activities, and in modern era it disrupted by technology. Distance and time was no longer an obstacle in terms of getting the desired goods or services. The buying and selling transaction is then called online buying and selling transaction, a term commonly used by business actors in Indonesia and even the world. Civilizations and actions of a person change drastically in fulfilling his desire to get something what he wants. The online buying and selling transaction is even considered the 5th Industrial Revolution for the order of trade and industrial civilization in the world today. This paper will see and examine online buying and selling transactions from the perspective of the International Private Law, because it is not impossible this online buying and selling transactions cross the border of the country. It is hoped that this paper will give different insight and perspective for readers about online transaction.
Demarcation of public and private in the discursive governance area
Authors: Карнаухова М. Д. 
Published: September 2019

The basic dichotomy of the public / private is analyzed in the context of the governance discourse functionality. Various assessments of private and public discourse, as well as governance discourse, rooted in different traditions of their understanding are identified. The article analyses the basic dichotomy of public / private in the context of the functionality of management discourse. It identifies different assessments of private and public discourses, as well as management discourse, rooted in different traditions of their comprehension.The subject lies in the concept of the discursive space of public governance as a polyphonic network of communicative events. It represents the mutual influence of power institutions, group agents of the management sphere and autonomous political actors. The discursive space is categorised in signs of management discourse: verbal and nonverbal; rich with information and factual (contact-making); figurative and abstractive; emotionally neutral and able to cause strong emotions; different by nature of referencing and functional orientation. Also, it defines the main types of its presentation: narratives with suggestive guidelines, which articulate social problems, and suggest ways to solve them.We analysed privacy (territoriality of a person) as a sociocultural phenomenon, which preservation in the transparent world of digital communications is becoming more problematic, requires interdisciplinary research and regulatory regulation. It has been found that the forceful transfer of the principles of private life into the public sphere, the replacement of public order with the private order, leads to their distortion, the priority of informal rules over formal ones, when the public space is getting filled with mysterious relationships with «insiders» and their personal interests.Finally, we revealed the essence of the idea of a new state management (NPM), which is based on the possibility of applying business management techniques to public administration. Although NPM is recognised as insufficient for a public administration system nowadays, it still is, however, considered partially effective and its elements are present in the strategic course of Ukraine.
Problems of realization of political and administrative reformation of public administration management system
Authors: Сак Ю. А. 
Published: September 2019

Political and administrative reform of the public administration system is the implementation of a setof public administration mechanisms aimed at modernizing and developing the public administrationsystem, optimizing public authorities and local self-government, changing communication between publicauthorities, forming an innovative model of public administration, and professionalizing the system of publicadministration directed on the formation of an efficient and effective system of public administration.The main problems of the implementation of the political and administrative reform of the publicadministration system should include the following:firstly, the absence of a substantiated and systematic Concept for the implementation of political andadministrative reform of the public administration system;secondly, the lack of specially trained personnel in the public administration system that are able to formulate and implement government-management decisions;thirdly, there are no systemic and optimal mechanisms for implementing the political and administrativereform of the public administration system;fourth, the lack of continuity in the implementation of reforms in society and their validity;fifth, the lack of scientifically substantiated models of the optimal system of public administration that canbe implemented in Ukraine;sixthly, the lack of a system for evaluating reforms in the public administration system;seventh, the slow struggle against corruption, affecting the quality of not only socio-economic reforms,but also reforming the system of public administration. Corruption not only impedes the development of theeconomy and civil society but also threatens modern reforms in Ukraine;eighth, the lack of political support for systemic reforms as the basis for the quality of such processes;ninth, lack of rationalization of the activities of state authorities and local self-government through therestructuring of the authorities and their optimization;tenth, the lack of information campaigns on the introduction of certain reforms, which negatively affectstheir perception by the population.
Hormone therapy for premenopausal women with metastatic breast cancer: combinations with cyclin-dependent kinase inhibitors
Authors: Artamonova E. V. , Kovalenko E. I. 
Published: September 2019

This article discusses the problems associated with the search of the most effective treatment strategies for HER2-negative metastatic breast cancer in premenopausal women. Until recently, ovarian suppression and hormone therapy had been the main treatments used in this group of patients. The development of palbociclib, called a “breakthrough therapy”, as well as promising results of trials evaluating the efficacy of cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors added to hormone therapy in postmenopausal women suggested a need for the assessment of this treatment regimen in combination with ovarian suppression in younger patients.According to the results of randomized trials and subgroup analysis, the addition of a CDK4/6 inhibitor to ovarian suppression and hormonal therapy significantly increases survival. The safety profile is similar to that of older patients. Randomized trials comparing the efficacy of palbociclib + ovarian suppression + aromatase inhibitor vs. chemotherapy in premenopausal women demonstrated significant benefits of a new treatment strategy: a CDK4/6 inhibitor as a part of combination therapy reduced the risk of progression by 36 % compared to capecitabine.
Toxicological and anatomical study of vegetative organs of Anthurium maricense Nadruz and Mayo (Araceae)
Authors: Guimarães André Luis de Alcantara , Tanque Patrique Riepe do , Pyrrho Alexandre dos Santos , Vieira Ana Cláudia de Macêdo 
Published: September 2019

Among other taxa of Araceae, the genus Anthurium is the largest of the family and one of themost important taxa. Some species of this genus have been used as a condiment, and its plantsas ornaments and medicines for over a century. Anthurium maricense is an endemic species from“restingas” of Rio de Janeiro, Brazil, and it is used as ornamental and medicinal plant. This paperaimed an anatomical and toxicological study of its vegetative organs. A. maricense has subterraneousrhizome, adventitious roots and complete leaves. The anatomical features of vegetative organs aresimilar to other species of Araceae and genus Anthurium, especially the velamen in roots and calciumoxalate crystals in all organs. Under scanning electron microscopy (SEM), longitudinal grooves wereobserved in the raphides. For toxicological analyses, whole (with crystals) and centrifuged (freefrom crystals) fractions of the juices of each organ were administered via mouthwash and plantarinoculation to groups of five mice. The formation of edema was observed at 1, 3, 6, 24 and 96hours and 7, 14, 21 and 28 days. The oral inoculations presented negative results for all groups,without edema. The plantar inoculations showed differing results: with centrifuged juices, mildedema formed but regressed; with whole juices, some animals presented severe edema. Our resultsindicated distribution and morphology of raphides and diverse chemical substances were related tothe edematogenic process. A. maricense may potentially induce more chronic edema if compared toother species of Araceae.Keywords: Anatomy. Crystals. Restinga. Toxicity.
A JUSTIÇA É TAMBÉM POLÍTICA: A PARTICIPAÇÃO DOS JUÍZES DE PERNAMBUCO NA FORMAÇÃO DO ESTADO BRASILEIRO (1835-1871)
Authors: Do Nascimento Alexsandro Ribeiro 
Published: September 2019

RESUMO. Este trabalho tem o objetivo de analisar a participação de alguns juízes pernambucanos na formação do estado do Brasil desde o período regencial até a Reforma Judiciária de 1871. O debate sobre a atuação desses magistrados é importante para compreender o funcionamento das instituições políticas, uma vez que estes poderiam acumular cargos no Judiciário e nas Casas Legislativas. Uma das questões sobre a atuação destes juízes é o diálogo que eles tinham com atores de diversas instituições. Por fazerem parte de um grupo considerado privilegiado dentro da província, e também no âmbito nacional, estes magistrados estavam inseridos em redes de relações construídas e sustentadas antes mesmo da formação do Estado imperial. Afinal, não tem como pensar a Justiça e o poder sem conhecer a origem portuguesa na qual nasceram e foram desenvolvidas as normas que regeram e ainda conduziam o país por séculos. Os juízes também podem ser identificados como atores que fazem parte e alimentam a cultura política deste período. Com isso, a análise do Judiciário vai além da movimentação e da atuação no Judiciário. O pensamento político destes personagens é fundamental para analisar o funcionamento das instituições e das relações sociais da época. Eles não serão tratados apenas como simples magistrados, mas como produtores de discursos políticos. O método do trabalho é a análise documental das instituições de Justiça no período como o Arquivo Público de Pernambuco, o Arquivo da Faculdade de Direito do Recife, e os jornais da época, bem como a análise de discurso dos magistrados.
How the Investor’s Risk Preferences Influence the Optimal Allocation in a Credibilistic Portfolio Problem
Authors: Georgescu Irina , Kinnunen Jani 
Published: September 2019

Abstract
A classical portfolio theory deals with finding the optimal proportion in which an agent invests a wealth in a risk-free asset and a probabilistic risky asset. Formulating and solving the problem depend on how the risk is represented and how, combined with the utility function defines a notion of expected utility. In this paper the risk is a fuzzy variable and the notion of expected utility is defined in the setting of Liu’s credibility theory. Thus, the portfolio choice problem is formulated as an optimization problem in which the objective function is a credibilistic expected utility. Different approximation calculation formulas for the optimal allocation of the credibilistic risky asset are proved. These formulas contain two types of parameters: Various credibilistic moments associated with fuzzy variables (expected value, variance, skewness and kurtosis) and the risk aversion, prudence and temperance indicators of the utility function.