bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal structural brain network and hemisphere-specific changes in bulimia nervosa
Authors: Wang Li , Bi Kun , An Jing , Li Meng , Li Ke , Kong Qing-Mei , Li Xue-Ni , Lu Qing , Si Tian-Mei 
Published: August 2019

AbstractBulimia nervosa (BN) is characterized by episodic binge eating and purging behaviors. Disrupted neural processes of self-regulation, taste-rewarding, and body image has been associated with the pathogenesis of BN. However, the structural basis for these behavioral and functional deficits remains largely unknown. We employed diffusion tensor imaging and graph theory approaches (including the nodal properties and network-based statistics (NBS)) to characterize the whole-brain structural network of 48 BN and 44 healthy women. For nodal measures of strength, local efficiency, and betweenness centrality, BN patients displayed abnormal increases in multiple left-lateralized nodes within the mesocorticolimbic reward circuitry (including the orbitofrontal cortex, anterior cingulate, insular, medial temporal, and subcortical areas), lateral temporal-occipital cortex, and precuneus, while reduced global efficiency was observed in the right-lateralized nodes within the dorsolateral prefrontal cortex, mesocorticolimbic circuitry, somatosensory and visuospatial system. Several mesocorticolimbic nodes significantly correlated with BN symptoms. At a network level, we found increased left-lateralized connections primarily within the orbitofrontal cortex and its connections to mesocorticolimbic and lateral temporal-occipital areas, but reduced right-lateralized connections across the inferior frontal gyrus and insula, as well as their connections to the lateral temporal cortex. This study revealed BN-related changes in white-matter connections across the prefrontal control, mesocorticolimbic reward, somatosensory and visuospatial systems. The hemispheric-specific change could be an important aspect of the pathophysiology of BN. By characterizing whole-brain structural network changes of BN, our study provides novel evidence for understanding the behavioral and functional deficits of the disorder.
Molecular cobalt corrole complex for the heterogeneous electrocatalytic reduction of carbon dioxide
Authors: Gonglach Sabrina , Paul Shounik , Haas Michael , Pillwein Felix , Sreejith Sreekumar S. , Barman Soumitra , De Ratnadip , Müllegger Stefan , Gerschel Philipp , Apfel Ulf-Peter , Coskun Halime , Aljabour Abdalaziz , Stadler Philipp , Schöfberger Wolfgang , Roy Soumyajit 
Published: August 2019

AbstractElectrochemical conversion of CO2 to alcohols is one of the most challenging methods of conversion and storage of electrical energy in the form of high-energy fuels. The challenge lies in the catalyst design to enable its real-life implementation. Herein, we demonstrate the synthesis and characterization of a cobalt(III) triphenylphosphine corrole complex, which contains three polyethylene glycol residues attached at the meso-phenyl groups. Electron-donation and therefore reduction of the cobalt from cobalt(III) to cobalt(I) is accompanied by removal of the axial ligand, thus resulting in a square-planar cobalt(I) complex. The cobalt(I) as an electron-rich supernucleophilic d8-configurated metal centre, where two electrons occupy and fill up the antibonding dz2 orbital. This orbital possesses high affinity towards electrophiles, allowing for such electronically configurated metals reactions with carbon dioxide. Herein, we report the potential dependent heterogeneous electroreduction of CO2 to ethanol or methanol of an immobilized cobalt A3-corrole catalyst system. In moderately acidic aqueous medium (pH = 6.0), the cobalt corrole modified carbon paper electrode exhibits a Faradaic Efficiency (FE%) of 48 % towards ethanol production.
A stable zirconium based metal-organic framework for specific recognition of representative polychlorinated dibenzo-p-dioxin molecules
Authors: Wang Bin , Wang Peilong , Xie Lin-Hua , Lin Rui-Biao , Lv Jie , Li Jian-Rong , Chen Banglin 
Published: August 2019

AbstractPolychlorinated dibenzo-p-dioxins (PCDDs), as a class of persistent and highly toxic organic pollutants, have been posing a great threat to human health and the environment. The sensing of these compounds is important but challenging. Here, we report a highly stable zirconium-based metal-organic framework (MOF), Zr6O4(OH)8(HCOO)2(CPTTA)2 (BUT-17) with one-dimensional hexagonal channels and phenyl-rich pore surfaces for the recognition and sensing of two representative PCDDs, 2,3-dichlorodibenzo-p-dioxin (BCDD) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), based on the fluorescence quenching. BUT-17 exhibits high sensing ability with the detection limits as low as 27 and 57 part per billion toward BCDD and TCDD, respectively, and is very selective as well without the interference of similar compounds. The recognition of BUT-17 toward BCDD is demonstrated by single-crystal structure of its guest-loaded phase, in which the fluorescence-quenched complexes form between the adsorbed BCDD molecules and the MOF host through π-π stacking and hydrogen bonding interactions.
Light-matter entanglement over 50 km of optical fibre
Authors: Krutyanskiy V. , Meraner M. , Schupp J. , Krcmarsky V. , Hainzer H. , Lanyon B. P. 
Published: August 2019

AbstractWhen shared between remote locations, entanglement opens up fundamentally new capabilities for science and technology. Envisioned quantum networks use light to distribute entanglement between their remote matter-based quantum nodes. Here we report on the observation of entanglement between matter (a trapped ion) and light (a photon) over 50 km of optical fibre: two orders of magnitude further than the state of the art and a practical distance to start building large-scale quantum networks. Our methods include an efficient source of ion–photon entanglement via cavity-QED techniques (0.5 probability on-demand fibre-coupled photon from the ion) and a single photon entanglement-preserving quantum frequency converter to the 1550 nm telecom C band (0.25 device efficiency). Modestly optimising and duplicating our system would already allow for 100 km-spaced ion–ion heralded entanglement at rates of over 1 Hz. We show therefore a direct path to entangling 100 km-spaced registers of quantum-logic capable trapped-ion qubits, and the optical atomic clock transitions that they contain.
Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells (MA09-hRPE) in macular degeneration
Authors: Qiu Tina Guanting 
Published: August 2019

AbstractThe use of human embryonic stem cell (hESC)-derived Retinal Pigment Epithelium (RPE) transplants has advanced dramatically in different forms for clinical application in macular degeneration. This review focuses on the first generation of hESC-RPE cell line, named as “MA09-hRPE” by Astellas Institute of Regenerative Medicine (AIRM), and its therapeutic application in human, which evaluated the safety and efficacy of MA09-hRPE cell line transplanted in patients with macular degeneration. This project marks the first milestone in overcoming ethical hurdles and oncogenic safety concerns associated with the use of an embryonic stem cell-derived line. Through in-depth, evidence-based analysis of the MA09-hRPE cell line, along with other hESC-RPE cell lines, this review aims to draw attention to the key technical challenges pertinent to the generation of a biologically competent hESC-RPE cell line and distill the four key prognostic factors residing in the host retina, which concurrently determine the outcomes of clinical efficacy and visual benefits. Given that the technology is still at its infancy for human use, a new clinical regulatory path could aid in cell line validation through small cohort, adaptive clinical trials to accelerate product development toward commercialization. These strategic insights will be invaluable to help both academia and industry, collaboratively shorten the steep learning curve, and reduce large development expenditures spent on unnecessary lengthy clinical trials.
High-performance visible light photodetectors based on inorganic CZT and InCZT single crystals
Authors: Shkir Mohd. , Khan Mohd Taukeer , Ashraf I. M. , Almohammedi Abdullah , Dieguez E. , AlFaify S. 
Published: August 2019

AbstractHerein, the optoelectrical investigation of cadmium zinc telluride (CZT) and indium (In) doped CZT (InCZT) single crystals-based photodetectors have been demonstrated. The grown crystals were configured into photodetector devices and recorded the current-voltage (I-V) and current-time (I-t) characteristics under different illumination intensities. It has been observed that the photocurrent generation mechanism in both photodetector devices is dominantly driven by a photogating effect. The CZT photodetector exhibits stable and reversible device performances to 632 nm light, including a promotable responsivity of 0.38 AW−1, a high photoswitch ratio of 152, specific detectivity of 6.30 × 1011 Jones, and fast switching time (rise time of 210 ms and decay time of 150 ms). When doped with In, the responsivity of device increases to 0.50 AW−1, photoswitch ratio decrease to 10, specific detectivity decrease to 1.80 × 1011 Jones, rise time decrease to 140 ms and decay time increase to 200 ms. Moreover, these devices show a very high external quantum efficiency of 200% for CZT and 250% for InCZT. These results demonstrate that the CZT based crystals have great potential for visible light photodetector applications.
Engineering of Magnetic Softness and Domain Wall Dynamics of Fe-rich Amorphous Microwires by Stress- induced Magnetic Anisotropy
Authors: Corte-León P. , Blanco J. M. , Zhukova V. , Ipatov M. , Gonzalez J. , Churyukanova M. , Taskaev S. , Zhukov A. 
Published: August 2019

AbstractWe observed a remarkable improvement of domain wall (DW) mobility, DW velocity, giant magnetoimpedance (GMI) effect and magnetic softening at appropriate stress-annealing conditions. Beneficial effect of stress-annealing on GMI effect and DW dynamics is associated with the induced transverse magnetic anisotropy. An improvement of the circumferential permeability in the nearly surface area of metallic nucleus is evidenced from observed magnetic softening and remarkable GMI effect rising. We assumed that the outer domain shell with transverse magnetic anisotropy associated to stress-annealing induced transverse magnetic anisotropy affects the travelling DW in a similar way as application of transversal bias magnetic field allowing enhancement the DW velocity. Observed decreasing of the half-width of the EMF peak in stress-annealed microwires can be associated to the decreasing of the characteristic DW width. Consequently, stress annealing enabled us to design the magnetic anisotropy distribution beneficial for optimization of either GMI effect or DW dynamics.
Multi-study reanalysis of 2,213 acute myeloid leukemia patients reveals age- and sex-dependent gene expression signatures
Authors: Roushangar Raeuf , Mias George I. 
Published: August 2019

AbstractIn 2019 it is estimated that more than 21,000 new acute myeloid leukemia (AML) patients will be diagnosed in the United States, and nearly 11,000 are expected to die from the disease. AML is primarily diagnosed among the elderly (median 68 years old at diagnosis). Prognoses have significantly improved for younger patients, but as much as 70% of patients over 60 years old will die within a year of diagnosis. In this study, we conducted a reanalysis of 2,213 acute myeloid leukemia patients compared to 548 healthy individuals, using curated publicly available microarray gene expression data. We carried out an analysis of normalized batch corrected data, using a linear model that included considerations for disease, age, sex, and tissue. We identified 974 differentially expressed probe sets and 4 significant pathways associated with AML. Additionally, we identified 375 age- and 70 sex-related probe set expression signatures relevant to AML. Finally, we trained a k nearest neighbors model to classify AML and healthy subjects with 90.9% accuracy. Our findings provide a new reanalysis of public datasets, that enabled the identification of new gene sets relevant to AML that can potentially be used in future experiments and possible stratified disease diagnostics.
LINC00511 is associated with the malignant status and promotes cell proliferation and motility in cervical cancer
Authors: Yu Chun-Ling , Xu Xiao-Ling , Yuan Fang 
Published: August 2019

Abstract
LINC00511 is a newly identified lncRNA that is up-regulated in many types of human cancers and may serve as an oncogenic lncRNA. However, there was no report about the role of LINC00511 in cervical cancer. Therefore, we investigated the clinical value of LINC00511 in cervical cancer patients via analyzing the correlation between LINC00511 expression and clinicopathological features. Moreover, we performed loss-of-function study to estimate the effect of LINC00511 on cervical cancer cell proliferation, migration, and invasion. In our study, we found LINC00511 expression levels were increased in cervical cancer tissues and cell lines compared with adjacent normal tissues and normal cervical epithelial cell line, respectively. High LINC00511 expression was correlated with advanced clinical stage, large tumor size, histological type of adenocarcinoma, and present lymph node metastasis, distant metastasis, and poor overall survival in cervical cancer patients. The in vitro studies indicated that knockdown of LINC00511 inhibited cervical cancer cell proliferation, migration, and invasion. In conclusion, LINC00511 acts as oncogenic lncRNA in cervical cancer, and may be a novel biomarker and potential therapeutic target for cervical cancer patients.
Language Comprehension After Mild Traumatic Brain Injury: The Role of Speed
Authors: Norman Rocío S. , Shah Manish N. , Turkstra Lyn S. 
Published: August 2019

Purpose
The aim of this study was to characterize language comprehension in mild traumatic brain injury (mTBI) by testing a speed-based hypothesis. We hypothesized that adults with mTBI would perform worse than a group of adults with orthopedic injuries (OIs) on an experimental language comprehension task.

Method

The study employed a prospective experimental design. Participants were 19 adults with mTBI and 19 adults with OI ages 18–55 years. Participants completed the
Whatdunit
task, a sentence agent selection task in speeded and unspeeded conditions.

Results
In the unspeeded condition, the mTBI group performed with a marginally significant higher accuracy than the OI group. In the speeded condition, the mTBI group performed with lower accuracy than the OI group; however, this difference did not reach statistical significance. There was a marginally significant interaction of Sentence Type × Group for reaction time in the speeded condition.

Conclusions
While our task might have been sensitive to cognitive processing abilities in both groups (as evidenced by the main effects of condition and sentence type), the task was not specific enough to capture mTBI-related deficits. The similarities in performance between both groups have clinical implications for the treatment of not just brain-related trauma but also trauma in general.
Leadership Opportunities for Clinicians Working With Stuttering and Other Fluency Disorders
Authors: Robinson Tommie L. 
Published: August 2019

Purpose
The purpose of this article is to inform readers of the importance of leadership and its relationship to the clinical management of stuttering and other fluency disorders. Using the American Speech-Language-Hearing Association Leadership Cultivation Model, examples of leadership activities are provided for each level of leadership.

Conclusion
There are many options for engaging in leadership, especially when developing programs, becoming a specialist, leading parent training programs, conducting presentations and grand rounds, participating in the publications process, leading a continuing education activity, writing public service announcements, and engaging in advocacy.
How do velocity structure functions trace gas dynamics in simulated molecular clouds?
Authors: Chira R.-A. , Ibáñez-Mejía J. C. , Mac Low M.-M. , Henning Th. 
Published: August 2019

Context. Supersonic disordered flows accompany the formation and evolution of molecular clouds (MCs). It has been argued that this is turbulence that can support against gravitational collapse and form hierarchical sub-structures.
Aims. We examine the time evolution of simulated MCs to investigate: What physical process dominates the driving of turbulent flows? How can these flows be characterised? Are they consistent with uniform turbulence or gravitational collapse? Do the simulated flows agree with observations?
Methods. We analysed three MCs that have formed self-consistently within kiloparsec-scale numerical simulations of the interstellar medium (ISM). The simulated ISM evolves under the influence of physical processes including self-gravity, stratification, magnetic fields, supernova-driven turbulence, and radiative heating and cooling. We characterise the flows using velocity structure functions (VSFs) with and without density weighting or a density cutoff, and computed in one or three dimensions. However, we do not include optical depth effects that can hide motions in the densest gas, limiting comparison of our results with observations.
Results. In regions with sufficient resolution, the density-weighted VSFs initially appear to follow the expectations for uniform turbulence, with a first-order power-law exponent consistent with Larson’s size-velocity relationship. Supernova blast wave impacts on MCs produce short-lived coherent motions at large scales, increasing the scaling exponents for a crossing time. Gravitational contraction drives small-scale motions, producing scaling coefficients that drop or even turn negative as small scales become dominant. Removing the density weighting eliminates this effect as it emphasises the diffuse ISM.
Conclusions. We conclude that two different effects coincidentally reproduce Larson’s size velocity relationship. Initially, uniform turbulence dominates, so the energy cascade produces VSFs that are consistent with Larson’s relationship. Later, contraction dominates and the density-weighted VSFs become much shallower or even inverted, but the relationship of the global average velocity dispersion of the MCs to their radius follows Larson’s relationship, reflecting virial equilibrium or free-fall collapse. The injection of energy by shocks is visible in the VSFs, but decays within a crossing time.
Effects of radiation in accretion regions of classical T Tauri stars
Authors: Colombo S. , Ibgui L. , Orlando S. , Rodriguez R. , Espinosa G. , González M. , Stehlé C. , de Sá L. , Argiroffi C. , Bonito R. , Peres G. 
Published: August 2019

Context. Models and observations indicate that the impact of matter accreting onto the surface of young stars produces regions at the base of accretion columns where optically thin and thick plasma components coexist. Thus, an accurate description of these impacts is necessary to account for the effects of absorption and emission of radiation.
Aims. We study the effects of radiation emerging from shock-heated plasma in impact regions on the structure of the pre-shock down-falling material. We investigate whether a significant absorption of radiation occurs and if it leads to a pre-shock heating of the accreting gas.
Methods. We developed a radiation hydrodynamics model describing an accretion column impacting onto the surface of a classical T Tauri star. The model takes into account the stellar gravity, the thermal conduction, and the effects of radiative losses and of absorption of radiation by matter in the nonlocal thermodynamic equilibrium regime.
Results. After the impact, a hot slab of post-shock plasma develops at the base of the accretion column. Part of the radiation emerging from the slab is absorbed by the pre-shock accreting material. As a result, the pre-shock accretion column gradually heats up to temperatures of 105 K, forming a radiative precursor of the shock. The precursor has a thermal structure with the hottest part at T ≈ 105 K, with a size comparable to that of the hot slab, above the post-shock region. At larger distances the temperature gradually decreases to T ≈ 104 K.
Conclusions. Our model predicts that ≈70% of the radiation emitted by the post-shock plasma is absorbed by the pre-shock accretion column immediately above the slab and is re-emitted in the UV band. This may explain why accretion rates derived from UV observations are systematically higher than rates inferred from X-ray observations.
Long-term temperature evolution of neutron stars undergoing episodic accretion outbursts
Authors: Ootes L. S. , Wijnands R. , Page D. 
Published: August 2019

Context. Transient neutron star low-mass X-ray binaries undergo episodes of accretion, alternated with quiescent periods. During an accretion outburst, the neutron star heats up due to exothermic accretion-induced processes taking place in the crust. Besides the long-known deep crustal heating of nuclear origin, a likely non-nuclear source of heat, dubbed “shallow heating”, is present at lower densities. Most of the accretion-induced heat slowly diffuses into the core on a timescale of years. Over many outburst cycles, a state of equilibrium is reached when the core temperature is high enough that the heating and cooling (photon and neutrino emission) processes are in balance.Aims. We investigate how stellar characteristics and outburst properties affect the long-term temperature evolution of a transiently accreting neutron star. For the first time the effects of crustal properties are considered, particularly that of shallow heating.Methods. Using our codeNSCool, we tracked the thermal evolution of a neutron star undergoing outbursts over a period of 105yr. The outburst sequence is based on the regular outbursts observed from the neutron star transient Aql X-1. For each model we calculated the timescale over which equilibrium was reached and we present these timescales along with the temperature and luminosity parameters of the equilibrium state.Results. We performed several simulations with scaled outburst accretion rates, to vary the amount of heating over the outburst cycles. The results of these models show that the equilibrium core temperature follows a logarithmic decay function with the equilibrium timescale. Secondly, we find that shallow heating significantly contributes to the equilibrium state. Increasing its strength raises the equilibrium core temperature. We find that if deep crustal heating is replaced by shallow heating alone, the core would still heat up, reaching only a 2% lower equilibrium core temperature. Deep crustal heating may therefore not be vital to the heating of the core. Additionally, shallow heating can increase the quiescent luminosity to values higher than previously expected. The thermal conductivity in the envelope and crust, including the potentially low-conductivity pasta layer at the bottom of the crust, is unable to significantly alter the long-term internal temperature evolution. Stellar compactness and nucleon pairing in the core change the specific heat and the total neutrino emission rate as a function of temperature, with the consequences for the properties of the equilibrium state depending on the exact details of the assumed pairing models. The presence of direct Urca emission leads to the lowest equilibrium core temperature and the shortest equilibrium timescale.