bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue transglutaminase activity in human gastric mucosa according to Helicobacter pylori infection
Authors: Pina Dore Maria , Pes Giovanni Mario , Errigo Alessandra , Manca Alessandra , Realdi Giuseppe 
Published: December 2018

Tissue transglutaminase (t-TG) is a multifunctional protein involved in the healing of gastric erosions and ulcers in animal models. The aim of this study was to measure gastric t-TG activity in patients with dyspepsia according to Helicobacter pylori infection and cytotoxin-associated gene A (cagA) and vacuolating cytotoxin (vacA) subtype status. Patients undergoing upper endoscopy not taking any medications were enrolled. Tissue-TG activity was determined in homogenates of antral specimens using a radiometric assay and was expressed in pmol/mg. The cagA and vacA genotypes were determined by PCR amplification using gene-specific oligoprimers. Data from 46 patients were available (17 of them were positive for H. pylori). Antral t-TG activity was significantly increased in H. pylori positive patients compared to H. pylori negative patients (6437 ± 3691 vs. 3773 ± 1530 pmol/mg; P = 0.001) according to Mann–Whitney U test. Patients with H. pylori negative gastritis had higher t-TG activity than patients with normal gastric mucosa. The specimens infected with cagA positive strains (72%) displayed greater t-TG activity than cagA negative samples (7358 ± 4318 vs. 4895 ± 1062 pmol/mg; P = 0.237). Similarly, t-TG activity was higher in H. pylori vacA s1/m1 strains vs. vacA s1/m2 (7429 vs. 5045 pmol/mg; P = 0.744), and vacA s1/m1 vs. s2/m2 (7429 vs. 4489 pmol/mg; P = 0.651) but the results were not significant. No differences were found between histology, endoscopy features and t-TG activity. These results show that t-TG activity is significantly greater in gastritis associated with H. pylori infection, suggesting that this enzyme is induced by inflammation and may have an important role in the natural history of human gastritis. Impact statement Tissue transglutaminase (t-TG) is unique among TG enzymes because of its additional role in several physiological and pathological activities, including inflammation, fibrosis, and wound healing. The presence of t-TG has previously been described in the intestine of human and animal models, yet studies on t-TG activity in human gastric mucosa are missing. Helicobacter pylori infection is the major cause of gastritis and peptic ulcers. For the first time, our results show that t-TG activity was significantly higher in antral specimens of patients with chronic active gastritis associated with H. pylori infection compared to H. pylori negative chronic gastritis and normal antral mucosa. These findings suggest that t-TG has a role in the natural history of human gastritis, which requires further investigation but may be an avenue for new therapeutic options.
RETRACTED ARTICLE: Long non-coding RNA HIF1A-AS2 facilitates adipose-derived stem cells (ASCs) osteogenic differentiation through miR-665/IL6 axis via PI3K/Akt signaling pathway
Authors: Wu Ruoyu , Ruan Jihao , Sun Yongjin , Liu Mengyu , Sha Zhuang , Fan Cunyi , Wu Qingkai 
Published: December 2018

Abstract
Background
This study was aimed to investigate the role and specific molecular mechanism of HIF1A-AS2/miR-665/IL6 axis in regulating osteogenic differentiation of adipose-derived stem cells (ASCs) via the PI3K/Akt signaling pathway.

Methods
RNAs’ expression profile in normal/osteogenic differentiation-induced ASCs (osteogenic group) was from the Gene Expression Omnibus database. The analysis was carried out using Bioconductor of R. Gene Set Enrichment Analysis and Kyoto Encyclopedia of Genes and Genomes dataset were applied to identify up- and downregulated signaling pathways. Co-expression network of specific lncRNAs and mRNAs was structured by Cytoscape, while binding sites amongst lncRNA, mRNA, and miRNA were predicted by TargetScan and miRanda. ASCs were derived from human adipose tissue and were authenticated by flow cytometry. ASC cell function was surveyed by alizarin red and alkaline phosphatase (ALP) staining. Molecular mechanism of HIF1A-AS2/miR-665/IL6 axis was investigated by RNAi, cell transfection, western blot, and qRT-PCR. RNA target relationships were validated by dual-luciferase assay.

Results
HIF1A-AS2 and IL6 were highly expressed while miR-665 was lowly expressed in induced ASCs. HIF1A-AS2 and IL6 improved the expression level of osteoblast markers Runx2, Osterix, and Osteocalcin and also accelerated the formation of calcium nodule and ALP activity, yet miR-665 had opposite effects. HIF1A-AS2 directly targeted miR-665, whereas miR-665 repressed IL6 expression. Moreover, the HIF1A-AS2/miR-665/IL6 regulating axis activated the PI3K/Akt signaling pathway.

Conclusions
LncRNA HIF1A-AS2 could sponge miR-665 and hence upregulate IL6, activate the PI3K/Akt signaling pathway, and ultimately promote ASC osteogenic differentiation.
Cultural engagement and incident depression in older adults: evidence from the English Longitudinal Study of Ageing
Authors: Fancourt Daisy , Tymoszuk Urszula 
Published: December 2018

BackgroundThere is a recognised need for the identification of factors that might be protective against the development of depression in older adults. Over the past decade, there has been growing research demonstrating the effects of cultural engagement (which combines a number of protective factors including social interaction, cognitive stimulation and gentle physical activity) on the treatment of depression, but as yet not on its prevention.AimsTo explore whether cultural engagement in older adults is associated with a reduced risk of developing depression over the following decade.MethodWorking with data from 2148 adults in the English Longitudinal Study of Ageing who were free from depression at baseline, we used logistic regression models to explore associations between frequency of cultural engagement (including going to museums, theatre and cinema) and the risk of developing depression over the following 10 years using a combined index of the Centre for Epidemiological Studies Depression Scale (CES-D) and physician-diagnosed depression.ResultsThere was a dose–response relationship between frequency of cultural engagement and the risk of developing depression independent of sociodemographic, health-related and social confounders. This equated to a 32% lower risk of developing depression for people who attended every few months (odds ratio (OR) = 0.68, 95% CI 0.47–0.99, P = 0.046) and a 48% lower risk for people who attended once a month or more (OR = 0.52, 95% CI 0.34–0.80, P = 0.003). Results were robust to sensitivity analyses exploring reverse causality, subclinical depressive symptoms and alternative CES-D thresholds.ConclusionsCultural engagement appears to be an independent risk-reducing factor for the development of depression in older age.Declaration of interestNone.
A systematic review and critical evaluation of inflammatory cytokine associations in hidradenitis suppurativa
Authors: Frew John W. , Hawkes Jason E. , Krueger James G. 
Published: December 2018

Background: The pathogenesis of hidradenitis suppurativa (HS) remains unclear. In order to develop effective treatment strategies, a deeper understanding of pathophysiology is needed. This is impaired by multiple small studies with inconsistent methodologies and the impact of co-occurring pro-inflammatory conditions such as smoking and obesity. Methods: This systematic review aimed to collate all published reports of cytokine studies in tissue, blood, serum and exudate. It was registered with PROSPERO (Registration number CRD42018104664) performed in line with the PRISMA checklist. Results: 19 studies were identified comprising 564 individual HS patients and 198 control patients examining 81 discrete cytokines. Methodology was highly varied and the quality of studies was generally low. There was a large degree of variance between the measured levels of cytokines. 78.2% of cytokines demonstrated heterogeneity by the chi-squared test for homogeneity and hence meta-analysis was not deemed appropriate. However, a strong and significant IL-17 signalling component was identified. Conclusions: Cytokines consistently elevated in lesional, peri-lesional and unaffected tissue are identified and discussed. Areas for further investigation include the role of dendritic cells in HS; the contribution of obesity, smoking, diabetes and the microbiome to cytokine profiles in HS; and examining the natural history of this disease through longitudinal measurements of cytokines over time.
Universalidad y derechos sociales: para una revisión constitucional de las políticas sociales en Argentina
Authors: Etchichury Horacio Javier 
Published: December 2018

ResumenEl texto analiza el alcance de la noción de universalidad en la titularidad de los derechos sociales contenidos en la Constitución argentina. Tras revisar la formulación de esa noción en el texto constitucional argentino y en los tratados de derechos humanos de igual jerarquía, el texto explora sus consecuencias respecto del diseño de políticas públicas, ponderando las modalidades focalizadas y condicionadas. Se propone revisar las políticas según su compatibilidad con el principio de universalidad. AbstractThe article analyzes the notion of universality in social rights entitlements under Argentina’s Constitution. After reviewing how this notion is phrased in the Constitution and binding human rights treaties endowed with constitutional rank, the article looks into the effects of universality in public policy design, implementation and appraisal. In particular, the article assesses targeted and conditional policies. Finally, the text advocates a policy revision according to consistency with the principle of universality.
Tecnología, relaciones laborales y Derecho del Trabajo: acerca de la tensión entre la técnica y la persona
Authors: Ambesi Leonardo 
Published: December 2018

El presente artículo tiene por objeto analizar el impacto que la revolución tecnológica provoca en el trabajador, sujeto protegido por el Derecho del Trabajo. A partir de la tensión entre las nociones de técnica y persona que la rama jurídica laboral porta desde su nacimiento, y con la ayuda de otras disciplinas, como la Historia, la Filosofía o la Sociología, se analiza el recorrido que ambos conceptos han transitado hasta la actualidad. En particular, se reflexiona sobre el modo en que el cambio tecnológico afecta el lugar privilegiado asignado normativamente al sujeto más débil de la relación productiva. En este contexto, se identifican algunas respuestas institucionales y judiciales que ya ofrece el ámbito internacional, para concluir en la necesidad de actualizar las herramientas interpretativas del Derecho del Trabajo con la finalidad de mantener su función compensadora, a la vez de permitir su convivencia armónica con el progreso técnico y económico.
Rapid identification of wood species by near-infrared spatially resolved spectroscopy (NIR-SRS) based on hyperspectral imaging (HSI)
Authors: Ma Te , Inagaki Tetsuya , Ban Mayuka , Tsuchikawa Satoru 
Published: December 2018

Abstract
Conventional near-infrared (NIR) spectroscopy has shown its potential to separate wood species nondestructively based on the aggregate effect of light absorption and scattering values. However, wood has an aligned microstructure, and there is a large refractive index (RI) mismatch between the wood cell wall substance (n≈1.55) and the cell lumen (air≈1.0, water≈1.33). Light scattering is dominant over absorption

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in wood, and this fact can be utilized for complex classification purposes. In this study, an NIR hyperspectral imaging (HSI) camera combined with one focused halogen light source (Ø 1 mm) was designed to evaluate the light scattering patterns of five softwood (SW) and 10 hardwood (HW) species in the wavelength range from 1002 to 2130 nm. Several parameters were combined to improve the data quality, such as image histogram plots of defined spaced bins (associated with diffuse reflectance values of light), variance calculation on the frequency (the number of pixels in each bin) of each histogram and the principal component analysis (PCA) of all the variance values at each wavelength. The identification accuracy of the quadratic discriminant analysis (QDA) under the five-fold cross-validation method was 94.1%, based on the first three principal component (PC) scores.
Microwave-Assisted Molten-Salt Facile Synthesis of Chromium Carbide (Cr3C2) Coatings on the Diamond Particles
Authors: Xu Lei , Wei Chenlong , Li Wei , Zhang Libo , Peng Jinhui 
Published: December 2018

Abstract
Chromium carbide (Cr3C2) coatings on the diamond were fabricated using the mixtures of molten salt of NaCl and BaCl2, powders of metallic chromium and diamond as raw materials in the temperature range of 750–900 °C by the microwave-assisted molten-salt synthesis. The morphology, microstructure and phase composition of the surface layer were characterized by Scanning Electron Microscopy, Energy-dispersive Spectrometry and X-ray diffraction. The results show that the surface of the diamond particles could be coated with Cr, forming a uniform and continuous Cr3C2-coated layer. The coatings thickness on the diamond can be controlled by adjusting the heating temperature and time. The coating thickness expanded from 0.73 to 2.30 µm when the temperature was increased from 750 °C to 900 °C, and increasing rapidly during the temperature range of 800  °C–850  °C, the coating thickness expanded from 1.30 to 2.80 µm when the holding time was increased from 0.5 h to 4 h. The results illustrate that the microwave-assisted molten salt synthesis plays a positive role in chromium coatings on the diamond, offering a potent method for the surface metallization of diamond.
A A Novel Risk Score to Predict New Onset Atrial Fibrillation in Patients Undergoing Isolated Coronary Artery Bypass Grafting
Authors: Lin Sophie Z , Crawford Todd C , Suarez-Pierre Alejandro , Magruder J Trent , Carter Michael V , Cameron Duke E , Whitman Glenn J , Lawton Jennifer , Baumgartner William A , Mandal Kaushik 
Published: December 2018

Background: Atrial fibrillation (AF) is common after cardiac surgery and contributes to increased morbidity and mortality. Our objective was to derive and validate a predictive model for AF after CABG in patients, incorporating novel echocardiographic and laboratory values.
Methods: We retrospectively reviewed patients at our institution without preexisting dysrhythmia who underwent on-pump, isolated CABG from 2011-2015. The primary outcome was new onset AF lasting >1 hour on continuous telemetry or requiring medical treatment. Patients with a preoperative echocardiographic measurement of left atrial diameter were included in a risk model, and were randomly divided into derivation (80%) and validation (20%) cohorts. The predictors of AF after CABG (PAFAC) score was derived from a multivariable logistic regression model by multiplying the adjusted odds ratios of significant risk factors (P < .05) by a factor of 4 to derive an integer point system.
Results: 1307 patients underwent isolated CABG, including 762/1307 patients with a preoperative left atrial diameter measurement. 209/762 patients (27%) developed new onset AF including 165/611 (27%) in the derivation cohort. We identified four risk factors independently associated with postoperative AF which comprised the PAFAC score: age > 60 years (5 points), White race (5 points), baseline GFR < 90 mL/min (4 points) and left atrial diameter > 4.5 cm (4 points). Scores ranged from 0-18. The PAFAC score was then applied to the validation cohort and predicted incidence of AF strongly correlated with observed incidence (r = 0.92).
Conclusion: The PAFAC score is easy to calculate and can be used upon ICU admission to reliably identify patients at high risk of developing AF after isolated CABG.
Prisión perpetua revisable: El caso colombiano desde la perspectiva constitucional
Authors: Montero Zendejas Daniel , Maldonado Arcón María Fernanda , Manrique Molina Filiberto Eduardo R. 
Published: December 2018

El presente artículo se ocupa del análisis de la figura jurídica de la prisión perpetua revisable, de acuerdo con sus antecedentes doctrinarios y su aplicabilidad en el derecho comparado, específicamente en países como Inglaterra, España, China, EE.UU., entre otros. Adicionalmente, se hace un estudio jurisprudencial de los casos más relevantes sometidos a consideración de Cortes internacionales, tal es el caso del Tribunal Europeo de Derechos Humanos y los Altos Tribunales de Austria, Suiza y Alemania, donde es sujeto de revisión la pena de prisión perpetua después de cumplida la condena por un determinado tiempo. Por último, se estudia la prohibición dentro del ordenamiento jurídico colombiano de la cadena perpetua por mandato constitucional y por disposición de tratados internacionales ratificados en Colombia, junto con el recedente jurisprudencial establecido por la Corte Constitucional y la Corte Suprema de Justicia.
Problematic overstudying: Studyholism or study addiction?
Authors: Loscalzo Yura , Giannini Marco 
Published: December 2018

This commentary addresses Griffiths et al. (2018)’s sixth myth about work addiction. We agree that work addiction could also be spread in the school context, although we propose that problematic overstudying may be more similar to an obsession than to an addiction toward the study. We refer to the DSM-5 diagnostic criteria related to the obsessive–compulsive disorder (OCD) and the substance-use disorder, presenting some theoretical considerations related to the similarities and differences between problematic overstudying and these two diagnoses. Finally, we focus on the obsessive–compulsive personality disorder. We conclude that problematic overstudying might better be conceptualized as an OCD-related disorder.
İnsan Hakları, Ahlak ve Kültür Açısından “Onur” Kavramına Yaklaşımın Kavramın Tanımlanmasına Etkileri
Authors: PARMAKSIZOĞLU Fatma Betül 
Published: December 2018

Onur, özellikle çok kültürlü ve çok dinli toplumlarda önemli olan barış, saygı, hoşgörü, insan hakları fikirleri “insanın değerli” bir varlık oluşu ile bağlantılı bir kavramdır. Tanımı ve içeriğini belirlemek ise oldukça zordur. Çünkü insan onuru, tarihi süreçte içeriği değişen, sosyal, felsefi, teolojik ve hukuki boyutları olan bir kavram olarak karşımıza çıkmaktadır. Batı toplumlarında “onur” kavramının, hukuki, ahlaki ve kültürel açıdan çeşitli tanımları yapılmakta, kavram analiz edilmektedir. Bu analiz, kavramın klasik ve modern olarak farklı şekillerde tanımlandığını göstermektedir. Kavramın algılanmasında semavi dinlerin etkili olduğu düşünülmektedir. Bununla birlikte bu dinlerin toplumsal barışa destek sağlaması da beklenmektedir. Dolayısıyla semavi dinlerin insana, onun haklarına verdiği değeri anlamak için, bireylerin dini dünya görüşlerini oluşturan Kutsal kitapların yeniden gözden geçirilmesi gerekmektedir. Bu çalışma, Semavi dinlerin kutsal kitaplarında onur kavramını inceleme dışında bırakarak, İslam dininin kavrama yaklaşım biçiminin nasıl olması gerektiğini kavramın anlaşılma biçimleri doğrultusunda tartışmaktadır.
ALGUNS ASPECTOS DA TRAJETÓRIA ESCOLAR DE PESSOAS COM FISSURA LÁBIO PALATAL
Authors: Silva Glorismar Gomes , Orlando Rosimeire Maria 
Published: December 2018

A fissura lábio palatal (FLP) é uma malformação congênita que afeta a região facial, em que a fenda comunica as regiões oral e nasal, provocando escape de ar pelo nariz e voz nasalizada. Estima-se que no Brasil a prevalência das FLP é de uma criança entre 650 nascimentos. Este estudo teve por objetivo descrever alguns aspectos da trajetória escolar de pessoas com FLP, sobretudo, o de verificar a percepção destas sobre algumas barreiras encontradas em seu trajeto escolar na educação básica. Participaram da pesquisa dois adultos que têm fissura de lábio e palato e realizaram todo o percurso da educação básica no ensino regular. Os participantes responderam a uma entrevista na qual foram abordados temas sobre sua escolarização. As entrevistas foram gravadas e analisadas qualitativamente e organizadas por meio de categorias, de acordo com os temas gerados. Os resultados mostraram que as dificuldades iniciais em função da fala não interferiram no processo de escolarização das alunas, bem como não impediram de concluírem a educação básica. Entretanto, em determinado momento da vida escolar passaram por alguma dificuldade, necessitando do apoio de profissionais especializados.
Palavras chave: Fissura Lábio Palatal. Trajetória escolar. Educação básica.
POLÍTICAS PÚBLICAS EDUCACIONAIS NA INTEGRAÇÃO DAS TIC NO ENSINO MÉDIO: CONTRIBUIÇÕES PARA A EDUCAÇÃO FÍSICA
Authors: Morisso Maríndia Mattos , De Vargas Tairone Girardon , Mallmann Elena Maria 
Published: December 2018

Este artigo tem como objetivo analisar como as TIC (Tecnologias de Informação e Comunicação) aparecem nas Diretrizes Curriculares Nacionais para o Ensino Médio e na Proposta Pedagógica para o Ensino Médio Politécnico do Rio Grande do Sul, destacando suas potencialidades para a Educação Física escolar. A discussão é apresentada a partir de uma análise documental da legislação vigente para o Ensino Médio, mesclada com resultados de revisão bibliográfica baseada em artigos de revistas de Educação Física. Ao longo da reflexão crítica pode ser percebido que as TIC são destacadas nas políticas públicas para o Ensino Médio, junto da cultura, do trabalho e sua importância está associada à produção e inovação científica. Nesse sentido, recursos tecnológicos como computadores, tablets, internet, entre outros, são oferecidos para as escolas, assim como formações para os professores promoverem a integração pedagógica das TIC. Portanto, as TIC aparecem com potencialidades na Educação Física, pois podem contribuir para que as aulas se tornem mais interativas. Desse modo, a integração das TIC no componente curricular pode ser uma alternativa para superar a visão reducionista da área, incentivando o desenvolvimento de práticas inovadoras.
Palavras-chave: Políticas Públicas. Ensino Médio. Educação Física. TIC.
UMA PROPOSTA DE PRÁTICAS PEDAGÓGICAS NO CURSO DE FORMAÇÃO INICIAL DE PROFESSORES DE EDUCAÇÃO FÍSICA
Authors: Paixão Jairo Antônio da 
Published: December 2018

O presente artigo apresenta uma proposta de práticas pedagógicas vivenciada por acadêmicos do curso de licenciatura em Educação Física numa escola da rede pública estadual na cidade de Viçosa, MG. Para além da articulação teoria e prática, o planejamento coletivo adotado pelo grupo de trabalho resultou em inúmeras possibilidades no trato didático pedagógico do conteúdo esportes paralímpicos com alunos regularmente matriculados no ensino médio, na referida escola de Educação Básica. Trata-se de uma experiência que oportunizou aos acadêmicos ampliar as perspectivas compreensivas da atividade docente por meio da análise, discussão, ação e reflexão alicerçadas no campo da Didática e Metodologia do Ensino da Educação Física. Proporcionou, ainda, a todos os participantes dessa proposta pedagógica um olhar mais atento sobre a importância de se adotar uma postura cooperativa para a melhoria das relações sociais, bem como da cooperação como elemento primordial para possibilitar conquistas coletivas, entre outras.
Palavras-chave: Prática pedagógica. Educação Física. Escola. Esportes paralímpicos.