bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biogeography of the freshwater fishes of the Guianas using a partitioned parsimony analysis of endemicity with reappraisal of ecoregional boundaries
Authors: Lemopoulos Alexandre , Covain Raphaël 
Published: July 2018

AbstractThe Guianas are one of the most diverse regions of the Neotropics, hosting a particularly high rate of freshwater fish endemism. The present distributional patterns of freshwater fish species in the major catchments of the Guianas (comprising Guyana, Suriname and French Guiana) were analysed to reveal the faunal relationships between rivers, evaluate different hypotheses concerning biogeographical units, and redefine the boundaries of the Guianese freshwater ecoregions. A parsimony analysis of endemicity was performed using a data partitioning strategy to alleviate some drawbacks inherent to the method (e.g. long branch attraction artefact, heterotachy), and take into account alternative parsimony models assigning different constraints on state changes for the different species. A strong spatial element was present in the data with a structuring of species along a west–east gradient. Two main biogeographical units were highlighted: one to the west, ranging from the Essequibo to the Commewijne rivers and including the Proto Berbice and Surinamese regions, and one to the east ranging from the Maroni to the Oyapock rivers and including the Western, Central and Eastern French Guiana regions. Each ecoregion possessed distinctive fish assemblages, and three to four potential zones of faunal exchanges between Amazonian and Guianese rivers have been confirmed.
An adaptive method for identifying marine areas of high conservation priority
Authors: Afán Isabel , Giménez Joan , Forero Manuela G. , Ramírez Francisco 
Published: July 2018

AbstractIdentifying priority areas for biodiversity conservation is particularly challenging in the marine environment due to the open and dynamic nature of the ocean, the paucity of information on species distribution, and the necessary balance between marine biodiversity conservation and essential supporting services such as seafood provision. We used the Patagonian seabird breeding community as a case study to propose an integrated and adaptive method for delimiting key marine areas for conservation. Priority areas were defined through a free decision‐support tool (Marxan) that included projected at‐sea distributions of seabirds (approximately 2,225,000 individuals of 14 species); BirdLife Important Bird and Biodiversity Areas (IBAs) for pelagic bird species; and the economic costs of potential regulations in fishing practices. The proposed reserve network encompassed approximately 300,000 km2that was largely concentrated in northern and southern inshore and northern and central offshore regions. This reserve network exceeded the minimum threshold of 20% conservation of the abundance of each species proposed by the World Parks Congress. Based on marine currents in the study area, we further identified the 3 primary water masses that may influence areas of conservation priority through water inflow. Our reserve network may benefit from enhanced marine productivity in these highly connected areas, but they may be threatened by human impacts such as marine pollution. Our method of reserve network design is an important advance with respect to the more classical approaches based on criteria defined for one or a few species and may be particularly useful when information on spatial patterns is data deficient. Our approach also accommodates addition of new information on seabird distribution and population dynamics, human activities, and alterations in the marine environment.
Drug‐Drug Interaction Study of Apixaban with Cyclosporine and Tacrolimus in Healthy Volunteers
Authors: Bashir Babar , Stickle Douglas F. , Chervoneva Inna , Kraft Walter K. 
Published: July 2018

Apixaban is metabolized by cytochrome P450 (CYP) 3A4 in the liver and intestine, undergoes direct intestinal excretion, and is a substrate to permeability glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) transporters. We examined the drug interactions between cyclosporine and tacrolimus (combined inhibitors of CYP3A4, P‐gp, and BCRP) with apixaban in 12 healthy adult male volunteers. Apixaban 10 mg was administered orally alone, in combination with 100 mg cyclosporine or 5 mg tacrolimus. Co‐administration with cyclosporine resulted in increase in apixaban maximum plasma concentration (Cmax) and area under the plasma concentration‐time curve from time zero to the last quantifiable concentration (AUC(0‐tlast)) with associated geometric mean ratios (GMRs) and 90% confidence intervals (CIs) of 143% (112, 183) and 120% (97, 148), respectively. Co‐administration with tacrolimus resulted in reduction in apixaban Cmax and AUC(0‐tlast) with associated GMRs (90% CI) of 87% (69, 112) and 78% (63, 97), respectively. The observed changes in apixaban exposure margins with cyclosporine or tacrolimus are within the range of the historical clinical development program, therefore, apixaban dose adjustments are not warranted.
Examining the factor structure of the Motives for Playing Drinking Games measure among Australian university students
Authors: George Amanda M. , Zamboanga Byron L. , Martin Jessica L. , Olthuis Janine V. 
Published: July 2018

AbstractIntroduction and AimsGiven the prevalence of drinking games among university students and the health risks associated with playing drinking games, it is important to consider motivations for participation. The psychometric properties of the Motives for Playing Drinking Games (MPDG) measure have been examined among US college student samples, but mixed findings have been reported regarding the number of factors in the measure. This is the first study to examine the factor structure and applicability of the MPDG measure among a sample of Australian university students.Design and MethodsUniversity students (N = 254; aged 18–46 years; 62% female) with prior drinking experience completed an online survey which included questions pertaining to demographics, drinking game frequency and consumption, drinking game consequences and the MPDG measure.ResultsConfirmatory factor analyses demonstrated that the originally proposed 8‐factors within the MPDG measure were problematic in the current sample and a revised 7‐factor solution was preferred. Analyses examining the relations of the revised 7 MPDG factors with drinking game behaviours (e.g. gaming‐specific consequences and amount consumed during play) highlighted the importance of some MPDG (enhancement/thrills, conformity and sexual pursuit motives).Discussion and ConclusionsWhile the MPDG measure shows promise for assessing drinking game‐specific motives, the need to consider the applicability of MPDG subscales across different samples was apparent.
Stability of retrospective self‐reports of childhood trauma in first‐episode psychosis
Authors: Simpson Samantha , Phillips Lisa , Baksheev Gennady , Garner Belinda , Markulev Connie , Phassouliotis Christina , Alvarez‐Jimenez Mario , McGorry Patrick , Bendall Sarah 
Published: July 2018

AimChildhood trauma (CT), abuse and neglect are commonly reported by individuals experiencing psychosis. However, there are concerns that acute psychotic symptoms, in particular delusions, may contribute to inaccurate reporting of CT. As a result, individuals experiencing psychosis may not be asked about their experiences of abuse when they are being seen in psychiatric settings. This lack of attention can directly impact on the tailoring of their clinical care. This study aimed to investigate the stability of reports of CT by young people experiencing a first psychotic episode (FEP) compared to healthy comparison subjects.MethodsResponses of 24 young people during the acute FEP and 3 months later to items on the Childhood Trauma Questionnaire (CTQ) were compared to 30 non‐psychiatric controls. All participants were aged 15 to 25 years.ResultsFEP participants reported higher CT than controls at both time points. Reliability analyses (interclass correlation coefficients [ICCs]) suggested strong agreement between CT reports at baseline and follow‐up for FEP participants (.81) and controls (.91). Positive psychotic symptoms were unrelated to CT reports. Although the severity of CT reports fluctuated between assessments, complete retractions of severe abuse claims occurred rarely.ConclusionsThe results suggest that retrospective self‐report can be used to reliably assess CT in young people experiencing acute psychosis.
Long‐term improvements after mindfulness‐based group therapy of depression, anxiety and stress and adjustment disorders: A randomized controlled trial
Authors: Sundquist Jan , Palmér Karolina , Memon Ashfaque A. , Wang Xiao , Johansson Leena M. , Sundquist Kristina 
Published: July 2018

BackgroundAlthough mindfulness‐based group therapies (MGTs) for depressive, anxiety or stress and adjustment disorders are promising, there is a substantial lack of knowledge regarding the long‐term improvements after such therapies in these common psychiatric disorders.MethodsTwo hundred and fifteen patients were randomized in a randomized clinical trial (RCT) (ClinicalTrials.gov ID: NCT01476371) conducted in 2012 at 16 primary healthcare centres in southern Sweden. The patients were randomized to MGT or treatment as usual (TAU) and completed four psychometric self‐rated scales after 8 weeks of treatment. Approximately 12 months after the completion of the 8‐week treatment, the same scales were repeated. Ordinal and generalized linear‐mixed models, adjusted for cluster effects, were used for the analysis.ResultsFor all four psychometric scales (MADRS‐S [Montgomery‐Åsberg Depression Rating Scale‐S], HADS‐D, HADS‐A [Hospital Anxiety and Depression Scale A and D] and PHQ‐9 [Patient Health Questionnaire‐9]) the scores at the 1‐year follow‐up were significantly improved (all P values <0.001) in both groups. Furthermore, there were no significant differences between the MGT and TAU in the psychometric scores at the 1‐year follow‐up.ConclusionsTo the best of our knowledge, this is the first RCT comparing the long‐term improvements after MGT with TAU. Although it cannot be excluded that our findings are a result of the natural course of common psychiatric disorders or other factors, they suggest a long‐term positive improvement after both MGT and TAU.
When is an alternative possibility robust?
Authors: Kittle Simon 
Published: July 2018

AbstractAccording to some, free will requires alternative possibilities. But not any old alternative possibility will do. Sometimes, being able to bring about an alternative does not bestow any control on an agent. In order to bestow control, and so be directly relevant qua alternative to grounding the agent's moral responsibility, alternatives need to be robust. Here, I investigate the nature of robust alternatives. I argue that Derk Pereboom's latest robustness criterion is too strong, and I suggest a different criterion based on the idea that what agents need to be able to do is keep open the possibility of securing their blamelessness, rather than needing to directly ensure their own blamelessness at the time of decision.
Reflections on, and visions for, the changing field of pollination ecology
Authors: Knight T. M. , Ashman T.‐L. , Bennett J. M. , Burns J. H. , Passonneau S. , Steets J. A. 
Published: July 2018

AbstractSince the launch ofEcology Lettersin 1998, the field of Pollination Ecology has changed considerably in its focus. In this review, we discuss the major discoveries across the past two decades. We quantitatively synthesise the frequency by which different concepts and topics appeared in the peer‐reviewed literature, as well as the connections between these topics. We then look forward to identify pressing research frontiers and opportunities for additional integration in the future. We find that there has been a shift towards viewing plant–pollinator interactions as networks and towards understanding how global drivers influence the plants, pollinators and the ecosystem service of pollination. Future frontiers include moving towards a macroecological view of plant–pollinator interactions, understanding how ecological intensification and urbanisation will influence pollination, considering other interactions, such as plant–microbe–pollinator networks, and understanding the causes and consequences of extinctions. Pollination Ecology is poised to advance our basic understanding of the ecological and evolutionary factors that shape plant–animal interactions and to create applied knowledge that informs conservation decision making.
Competition lifespan survival analysis in the Norwegian‐Swedish Coldblooded Trotter racehorse
Authors: Velie B. D. , Jäderkvist Fegraeus K. , Ihler C. F. , Lindgren G. , Strand E. 
Published: July 2018

SummaryBackgroundStudies of large racing populations have established clear differences in the career profile of stallions, mares and geldings. Multiple studies have also demonstrated positive effects on racing careers for horses that commence racing at a younger age. However, the applicability of these studies to small, native racing populations is unknown and warrants investigation.ObjectivesTo provide summary statistics for performance outcomes for the Norwegian‐Swedish Coldblooded Trotter and to document and provide evidence on the current differences in racing careers across age at first start groups, sexes and country of birth.Study designCohort study.MethodsPerformance data on the population of Norwegian‐Swedish Coldblooded Trotters born between 2000 and 2009 (n = 14,548) were acquired and used to describe and compare the racing careers of this native racing breed. Career length, career starts and career earnings were evaluated. Kaplan–Meier survival curves, stratified by sex, age group and country of birth were produced for career length. A Cox proportional hazards model was fitted to assess factors influencing the hazard rate of retirement from racing.ResultsLog‐rank test for equality of career length survival functions showed significant differences (P<0.001) across sexes, countries of birth and age at first start groups. An increased age at first start increased the hazard rate of retirement from racing.Main limitationsRacing career length is influenced by many factors. While this study accounts for some of the known influences on career length, the analysis would be strengthened by the inclusion of additional information, such as trainer and reasons for retirement.ConclusionsThe results of this study suggest no adverse effects to the racing of young Norwegian‐Swedish Coldblooded trotters. The study also establishes significant differences in career length based on sex and identifies that these differences are the opposite of what is seen in many other horse racing breeds.
The Summary is available in Spanish – see Supporting Information
Deficiency of the basic helix‐loop‐helix transcription factor DEC1 prevents obesity induced by a high‐fat diet in mice
Authors: Noshiro Mitsuhide , Kawamoto Takeshi , Nakashima Ayumu , Ozaki Noritsugu , Ueno Toshinori , Saeki Masayumi , Honda Kiyomasa , Fujimoto Katsumi , Kato Yukio 
Published: July 2018

AbstractObesity is a major public health problem in developed countries resulting from increased food intake and decreased energy consumption and usually associated with abnormal lipid metabolism. Here, we show that DEC1, a basic helix‐loop‐helix transcription factor, plays an important role in the regulation of lipid consumption in mouse brown adipose tissue (BAT), which is the major site of thermogenesis. Homozygous Dec1 deletion attenuated high‐fat‐diet‐induced obesity, adipocyte hypertrophy, fat volume and hepatic steatosis. Furthermore, DEC1 deficiency increased body temperature during daytime and enhanced the expression of uncoupler protein 1, a key factor of thermogenesis, and various lipolysis‐related genes in interscapular BAT. In vitro experiments suggested that DEC1 suppresses the expression of various lipolysis‐related genes induced by the heterodimer of peroxisome proliferator‐activated receptor γ and retinoid X receptor α (RXRα) through direct binding to RXRα. These observations suggest that enhanced lipolysis in BAT caused by DEC1 deficiency leads to an increase in lipid consumption, thereby decreasing lipid accumulation in adipose tissues and the liver. Thus, DEC1 may serve as an energy‐saving factor that suppresses lipid consumption, which may be relevant to managing obesity.
Clinical significance of PDEF factor expression and its relation to androgen receptor in ER− breast cancer
Authors: Cao Lu , Li Congying , Xu Cong , Xiang Guomin , Liu Fang , Liu Xiaozhen , Jiao Jiao , Lv Shuhua , Niu Yun 
Published: July 2018

AimsThe mechanism of androgen receptor (AR) promoting tumour growth in oestrogen receptor‐negative (ER−) breast cancer (BC) is undetermined. Prostate‐derived ETS factor (PDEF) is highly restricted to the hormone‐regulated tissues of epithelial cells, such as those in the prostate, breast and other tissues. It has been demonstrated that PDEF expression is associated with AR in prostate cancer. In this research, we aimed to investigate the relationship between PDEF and AR in ER− BC.Methods and resultsWe immunohistochemically evaluated the correlation between PDEF and AR expression in 246 cases of ER− invasive BC, and investigated their relationship in ER− BC cell lines. The expression of PDEF was associated with the positive expression of AR (P < 0.001) and a worse survival rate (P = 0.006). PDEF+ tumours were significantly more often AR+ (P < 0.001). AR and PDEF were more often co‐expressed and the series of AR+PDEF+ (126 of 246, 51.2%) had a poor survival rate (P = 0.046). In Cox models, PDEF expression (P = 0.028) was an independent predictor for overall survival (OS). At the cellular protein and mRNA levels, our experiments also showed a statistically significant positive correlation between PDEF and AR, and that PDEF may be regulated by AR.ConclusionsPDEF is associated with markers of bad prognosis, supporting its role as a growth promoter in ER− BC. Our findings also provide evidence that PDEF is strongly correlated with AR expression in ER− breast cancer; it may be a downstream target gene of AR and a potential prognostic factor in ER− BC.
TFE3 translocation and protein expression in renal cell carcinoma are correlated with poor prognosis
Authors: Lee Hyun Jung , Shin Dong Hoon , Kim So Young , Hwang Chung Su , Lee Jung Hee , Park Won Young , Choi Kyung Un , Kim Jee Yeon , Lee Chang Hun , Sol Mee Young , Rha Seo Hee , Park Sung Woo 
Published: July 2018

AimsSince Xp11.2 translocation‐associated renal cell carcinoma (TRCC) was first recognised, its morphological features and the clinical significance of TFE3 expression, frequency of gene translocation and diagnostic criteria have been the subject of limited studies. The present retrospective analysis aimed to evaluate the correlation between TFE3 immunoreactivity and its gene translocation status using fluorescence in‐situ hybridisation (FISH) and determine how TFE3 translocation and expression affect patient prognosis differently.Methods and resultsWe enrolled 303 consecutive renal cell carcinoma cases. Immunohistochemical staining for TFE3 was performed in 303 cases, and FISH analysis was performed for molecular testing. The TCGA data set of renal cell carcinoma was evaluated to validate TFE3 expression and survival analysis. TFE3 expression was associated significantly with the nested alveolar pattern, papillary pattern, eosinophilic cytoplasm, voluminous expansile cytoplasm, nuclear grade, tumour necrosis, sarcomatoid pattern and picket fence appearance. FISH analysis showed break‐apart signals in 26 of 32 (81.25%) cases expressing strong or moderate nuclear TFE3 immunoreactivity. Thirteen of 56 samples that showed no or weak TFE3 expression with morphologically suspicious cases were translocation‐positive in the FISH assay. The TFE3‐translocation group (harbouring TFE3 translocation regardless of TFE3 expression) showed the poorest progression‐free survival (PFS), and the TFE3‐expressing group (expressing TFE3 but negative for translocation) was correlated significantly with decreased PFS.ConclusionIncreased TFE3 expression in RCC was associated with poor PFS regardless of the gene translocation status. Moreover, morphological analysis should help to select candidates who would benefit from TFE3 staining and FISH analysis.
Interorganizational Performance Management: A Co‐evolutionary Model
Authors: van Fenema Paul C. , Keers Bianca M. 
Published: July 2018

AbstractMaking interorganizational cooperation successful proves a daunting task. While current approaches to interorganizational performance management (PM) highlight why interorganizational cooperation matters and which phases are required, it remains silent on the dynamics of interorganizational PM. That is, how can PM evolve with and contribute to interorganizational cooperation. The purpose of this paper is to increase understanding of interorganizational PM. To this end, it develops a structure and process foundation of interorganizational value creation, and it provides a model that shows how processes of organizational and interorganizational PM co‐evolve. The study starts by providing insight into differences between organizational and interorganizational PM. It then presents five approaches pertaining to performance in interorganizational cooperation. The paper distinguishes strategic–economic, PM, supply‐chain management, organizational and marketing approaches. These approaches are related from a structure and process angle and are used to develop a co‐evolutionary model of interorganizational PM. The resulting conceptualization has implications for research on new modes of complex and heterogeneous interorganizational value creation. The paper elaborates on these implications, pointing to new directions for future PM research.
Reviewing and Theorizing the Unintended Consequences of Performance Management Systems
Authors: Franco‐Santos Monica , Otley David 
Published: July 2018

AbstractDifferent design choices in the controls used to manage performance often lead to a range of unintended consequences, which have profound effects on individuals and organizations. This paper presents a mixed review (both systematic and eclectic) of the literature on the unintended consequences of performance management systems, and develops a typology to explain how and why they occur. It finds that the most salient unintended consequences of directive performance management systems are gaming, information manipulation, selective attention, illusion of control and relationships transformation. It argues that these consequences exist as a result of limiting factors such as ignorance, error, short‐term concerns, fundamental values, self‐fulfilling forecasts and changes in social relationships. The emerging typology‐based theory suggests that the choice of control mechanisms is based on two key assumptions concerning goal‐alignment and goal‐uncertainty that relate back to ideas in agency theory and stewardship theory. It concludes that, in the design of performance management systems, the more the ‘assumed’ reality about the state of goal‐alignment and goal‐uncertainty diverges from the ‘real’ state of affairs, the more the resultant system is likely to create perverse unintended consequences, leading to poor organizational outcomes.