bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass Spectrometry Advances in Analysis of Glioblastoma
Authors: Al Shboul Sofian , Singh Ashita , Kobetic Renata , Goodlett David R. , Brennan Paul M. , Hupp Ted , Dapic Irena 
Published: November 2024

ABSTRACTSome cancers such as glioblastoma (GBM), show minimal response to medical interventions, often only capable of mitigating tumor growth or alleviating symptoms. High metabolic activity in the tumor microenvironment marked by immune responses and hypoxia, is a crucial factor driving tumor progression. The many developments in mass spectrometry (MS) over the last decades have provided a pivotal tool for studying proteins, along with their posttranslational modifications. It is known that the proteomic landscape of GBM comprises a wide range of proteins involved in cell proliferation, survival, migration, and immune evasion. Combination of MS imaging and microscopy has potential to reveal the spatial and molecular characteristics of pathological tissue sections. Moreover, integration of MS in the surgical process in form of techniques such as DESI‐MS or rapid evaporative ionization MS has been shown as an effective tool for rapid measurement of metabolite profiles, providing detailed information within seconds. In immunotherapy‐related research, MS plays an indispensable role in detection and targeting of cancer antigens which serve as a base for antigen‐specific therapies. In this review, we aim to provide detailed information on molecular profile in GBM and to discuss recent MS advances and their clinical benefits for targeting this aggressive disease.
The Impact of Depression and Anxiety Comorbidities on Acute Postoperative Pain After DIEP Flap Breast Reconstruction
Authors: Wang Carol , Tang Megan , Shah Reanna , Frost Jamie , Kim Esther , Shamamian Peter E. , Oleru Olachi , Seyidova Nargiz , Henderson Peter W. , Taub Peter J. 
Published: November 2024

ABSTRACTBackgroundDepression and anxiety have a complex association with opioid dependence, though their impact on acute postoperative pain is unclear. The present study investigated the impact of depression and anxiety on acute postoperative pain and opioid requirements following deep inferior epigastric perforator (DIEP) flap breast reconstruction.MethodsPatients receiving DIEP flap breast reconstruction were retrospectively identified from 2019 to 2023. Patients were classified into the psychiatric comorbidity (PC) group based on a history of depression or anxiety diagnoses, or the control group. Pain (0–10 Numerical Rating Scale [NRS]) scores and cumulative inpatient opioid requirements (in morphine milli‐equivalents [MMEs]) were compared between groups. Linear regression analysis assessed the association of psychiatric comorbidities with pain outcomes.ResultsIn total, 557 patients were included, of which 11.4% reported a psychiatric history. The PC group was younger (50.0 vs. 52.7 years, p = 0.032) and more frequently reported current marijuana use (15.6% vs. 4.3%, p = 0.001) and former smoking (51.6% vs. 24.5%, p < 0.001). The PC group had higher mean (2.5 vs. 2.0, p < 0.001) and maximum pain scores (8.6 vs. 7.8, p = 0.003) than the control group, which corresponded to higher opioid requirements (256 vs. 223 MMEs, p = 0.041). Psychiatric comorbidities were associated with higher average and maximum pain scores (p < 0.01) while current marijuana use was associated with higher opioid requirements (p = 0.033).ConclusionPatients with depression or anxiety comorbidities tended to have greater acute postoperative pain and opioid consumption. Marijuana use was also more prevalent, potentially exacerbating pain outcomes, and risk of opioid dependence. These findings will inform patient discussions and targeted interventions to mitigate opioid misuse.
Impact of Persistent Alopecia on Quality of Life in Childhood Cancer and Transplant Survivors
Authors: Kim Eun Jae , Hlobik Madeline , Berbert Laura , Brace‐O'Neill Jill , Vrooman Lynda , Huang Jennifer T. 
Published: November 2024

ABSTRACTBackgroundWhile alopecia associated with chemotherapy, radiation, or hematopoietic stem‐cell transplant (C/R/HSCT) is transient in most children, prior reports indicate nearly one in seven childhood cancer survivors suffer from persistent alopecia after their treatment is completed. The objective of our study was to better characterize the impact of C/R/HSCT‐associated persistent alopecia on patient quality of life.ProcedureA cross‐sectional cohort study of patients with a history of C/R/HSCT who were seen at Dana Farber Cancer Institute/Boston Children's Hospital Dermatology from August 2023 to February 2024 for any indication was conducted. Patients who completed their C/R/HSCT treatment regimen >6 months prior to visit were invited to fill out a survey on patient experience with persistent alopecia, including a modified Children's Dermatology Life Quality Index (CDLQI). Participants also underwent a full scalp examination.ResultsTwenty one out of 47 (44.7%) patients in our cohort self‐reported persistent alopecia. For nine additional patients, alopecia was not self‐reported but noted by a dermatologist on exam. Median self‐reported alopecia severity was 3 (interquartile range [IQR] 2–5.25) on a visual analog scale of 1–10. The most common pattern of alopecia was diffuse thinning. Median CDLQI score was 5 (IQR 2–7) for those with persistent alopecia, indicating a small negative effect of disease on patient quality of life. Fifteen (31.9%) patients report receiving information about persistent alopecia prior to their C/R/HSCT.ConclusionsNearly half of childhood cancer and transplant survivors evaluated by dermatology suffered from persistent alopecia, which negatively impacted their quality of life. Better counseling on persistent alopecia should be provided to childhood cancer patients.
Effective Use of ALK Inhibitors in EML4::ALK‐Positive Lymphatic Malformations
Authors: Apsel Winger Beth , Dowd Christopher F. , Shimano Kristin A. , Devine W. Patrick , Mathes Erin , Frieden Ilona , Schaefer Carrie , Kothari Alok 
Published: November 2024

ABSTRACTGenetically targeted medications are emerging as important therapies for lymphatic malformations (LMs) unresponsive to sirolimus. We describe two patients with EML4::ALK‐positive LMs, one with Gorham Stout disease and one with a large genitourinary (GU) LM, who were successfully treated with ALK inhibitors. This report adds ALK inhibitors to the growing toolbox of molecularly targeted therapies for LMs.
Extended Failure Mode and Effects Analysis for Development of Hot Desert Test Cycle Proposal
Authors: Adothu Baloji , Mathiak Gerhard , Aly Shahzada Pamir , Alheloo Ahmad , Almheiri Ali , Alberts Vivian , Jäckel Bengt , Gottschalg Ralph , Shiradkar Narendra S. , Abdallah Amir A. , Garcia Juan Lopez , Salvador Michael , Hoex Bram , John Jim Joseph , Kazem Hussein A. , Alam Muhammad Ashraful 
Published: November 2024

ABSTRACTA growing number of gigawatt‐scale photovoltaic (PV) power plants are being established in hot desert regions worldwide, which are favored for their vast available land, high solar irradiance, long sunshine hours, and relatively low maintenance needs. This study combines insights from global PV experts on degradation rates, failure mode and effects analysis (FMEA), and desert weather conditions to develop a hot desert test cycle (HDTC). The average degradation rate for PV modules installed in hot desert regions over the past 10 years is estimated to be around 1.63% per year. Eighteen failure modes were identified and analyzed using FMEA. According to the results, the main degradation mechanisms include UV light‐induced degradation (UVLID), thermomechanical failures in interconnects and fingers, light‐elevated temperature‐induced degradation (LeTID), and abrasion of the glass and antireflection coatings. A radar map comparison shows that desert environments experience UV exposure, ambient, and module temperatures that are more than twice as high as those in moderate climates. The HDTC protocol was developed based on FMEA results and desert‐specific weather conditions. It includes tests for desert UV exposure, temperature cycles, mechanical loads, and sand/brush abrasions. To ensure consistency across countries, there is a plan to establish an internationally recognized standard that complements existing IEC standards. As the industry grows, desert regions are expected to place greater emphasis on adopting desert‐specific testing standards for the qualification and evaluation of PV modules.
Sign language in d/deaf students' spoken/written language development: A research synthesis and meta‐analysis of cross‐linguistic correlation coefficients
Authors: Zhang Dongbo , Ke Sihui , Yang Junhui , Anglin‐Jaffe Hannah 
Published: November 2024

AbstractThis paper presents the first systematic review and meta‐analysis on cross‐linguistic correlations between sign language and spoken/written language competences in bilingual d/Deaf learners. A total of 202 effect sizes were identified based on 70 independent samples that appeared in 52 studies from 1981 to 2023 (N = 3570). The effect sizes involved seven sign language correlates (e.g., fingerspelling, phonological awareness [PA], lexico‐semantic knowledge) and eight spoken/written language correlates (e.g., PA, lexico‐semantic knowledge, word reading, reading comprehension). Estimated mean correlations of 26 cross‐linguistic relationships ranged from r = 0.322 (p < 0.001) for sign language PA and reading comprehension to r = 0.645 (p < 0.001) for fingerspelling and word reading. Among other moderators, age/grade (elementary, secondary, vs. university/adult), signer status (native vs. non‐native), program type (bilingual vs. Total Communication/SimCom), and task type (passage vs. sentence comprehension) either showed significant moderation effects or resulted in differing size (small, medium vs. large) in the correlation coefficients among subgroups of primary studies. The meta‐analytic findings lend support to the legitimate application of linguistic interdependence, common underlying proficiency, cross‐linguistic transfer facilitation, and their associated constructs to the educational development of signing/bimodal bilingual learners. The moderator analysis results, in particular, have shed light on the conditioning of linguistic interdependence and transfer and expanded current understandings about the complexity of the issue and its practical implications in bilingual deaf education.
Sustainable development: Notions, numbers, and narratives
Authors: Holden Erling , Linnerud Kristin , Bøe Vegard 
Published: November 2024

AbstractThis article contributes to the theoretical knowledge of sustainable development operationalized in a sustainable development space based on three sustainable development imperatives: needs, justice, and limits. The space is constituted by six primary goals with associated key indicators and thresholds. Moreover, the article contributes to empirical knowledge about where different countries are in relation to this space based on data from 144 countries by using cluster analyses. The analyses show that no country is currently in the sustainable development space, but that sustainable development is possible. Finally, the article contributes to the growing literature on the use of narratives as important elements in change processes in general and sustainable development in particular. We present four big sustainable development narratives: “the right to education for all,” “leave no one behind,” “a carbon‐free energy system,” and “make room for nature.” These narratives are fundamental in the sense that they are a prerequisite for achieving sustainable development.
The School Bullying Victimization in Adolescents With Non‐Suicidal Self‐Injury: The Role of Coping Strategies and Emotion Regulation
Authors: Wang Yang , Wang Tingwei , Wang Jiesi , Zeng Lingyun , Li Guohua , Li Junchang , Zhou Yongjie , Wang Yanni 
Published: November 2024

ABSTRACTThe present study aimed to investigate the relationship between school bullying victimization and non‐suicidal self‐injury (NSSI) frequency, taking into consideration the mediating roles of coping strategies and emotional regulation. Participants were 12‐18‐year‐old outpatients and inpatients who met the NSSI and depressive disorder criteria according to the DSM‐5. Assessments included the Multidimensional Peer‐Victimization Scale, Coping Style Scale for Middle School Students, Emotion Regulation Questionnaire for Children and Adolescents, and the Functional Assessment of Self‐Mutilation to examine the bullying victimization, coping strategies, emotion regulation, and NSSI behaviour. Serial multiple mediation effects of coping strategies and emotion regulation between bullying victimization and NSSI frequency were analysed using the SPSS macro PROCESS programme. A total of 2335 participants were included in this study. Bullying victimization significantly predicted NSSI frequency (B = 0.191, p < 0.001). Both coping strategies and emotion regulation were important mediators in the relationship between bullying victimization and NSSI frequency. Bullying victimization indirectly affected NSSI through two serial mediation pathways: (1) bullying victimization → problem‐focused coping → cognitive reappraisal → NSSI frequency, and (2) bullying victimization → emotion‐focused coping→ expressive suppression → NSSI frequency. The study revealed a positive association between bullying victimization and the frequency of NSSI among adolescents with depressive disorder. Strategies of coping and emotional regulation significantly mediated the link between bullying victimization and the frequency of NSSI. The findings suggested that supporting adolescents in adopting effective coping and emotional regulation strategies could be a crucial approach to mitigate the impact of bullying victimization on the frequency of NSSI.
Traditional and modern methods of construction: Comparative study of the sustainability of single‐family homes
Authors: Josa Irene , de la Fuente Albert 
Published: November 2024

AbstractModern construction methods, such as additive manufacturing, are aimed to enhance the efficiency and quality of construction processes while potentially reducing waste generation and material use, thus contributing to sustainability performance (SP). However, comprehensively understanding the sustainability trade‐offs associated with these methods is crucial for guiding both research and practical applications toward sustainable development. This study aims at quantifying the SP of various construction methods for housing, including traditional, prefabricated, and additive manufacturing approaches. A sustainability index, integrating economic, environmental, social, and technological criteria, is utilized to assess different alternatives. Findings reveal promising aspects of 3D printing technologies, such as potential cost reductions through scale increase and process optimization, minimized material waste generation, creation of skilled employment opportunities, and enhanced construction flexibility and ease. Nevertheless, challenges persist, notably significant greenhouse gas emissions and limited supplier availability. Addressing these challenges is imperative for advancing the sustainable implementation of additive manufacturing in construction.
Edge Influence in a Semi‐Deciduous Tropical Forest: An Investigation of Soil Organic Carbon Fractions
Authors: Barreto‐Garcia Patrícia Anjos Bittencourt , Lopes Francielle da Silva , Monroe Paulo Henrique Marques , Paula Alessandro de , Martins Kyegla Beatriz da Silva , Nunes Marcio Renato 
Published: November 2024

ABSTRACTRecent studies have proven the sensitivity of soil organic carbon (SOC) in responding to variations imposed by tropical forest fragmentation, which may reflect changes in both its quantity and quality. Despite this, studies evaluating soil carbon fractions as an edge effect indicator are still non‐existent. We developed this work asking: How do the oxidizable fractions of soil organic carbon (OFSOC) respond to the edge effect in fragments of semi‐deciduous seasonal forest? Is this response influenced by the size of the forest fragment? The study was conducted in Vitória da Conquista, Bahia, Brazil, in three forest fragments with different sizes. Thus, three sampling sections were defined in each fragment: edge (0–10 m), transition (40–50 m), and interior. Soil samples were collected at a depth of 0–10 cm. The SOC was divided into three fractions (LC—labile carbon, MLC—moderately labile carbon, and LLC—low labile carbon), adopting the chemical method based on oxidation degrees. Reductions in the SOC (28.2%), LC (17.4%), and MLC content (66.7%) were observed at the edge in the small fragment. There was a reduction of SOC (21.3%) and LLC (39.0%) at the edge in the medium fragment, while MLC showed an increase at the edge (70.4%). The OFSOC were able to respond to the changes imposed by the edge effect, with emphasis on the LC and MLC fractions in smaller fragments. The forest fragment size influenced the level of changes caused by the edge effect in OFSOC, showing greater susceptibility in smaller fragments.
Portal venous gas in a domestic shorthair cat with large cell lymphoma
Authors: Waldron Carly , Heo Jin Y. , Vinayak Arathi 
Published: November 2024

AbstractPortal venous gas is defined as air within the portal venous system, whereas pneumobilia is defined as gas within the biliary tract. This report describes an 11.5‐year‐old female spayed domestic shorthair being managed for large cell lymphoma. While being hospitalised, the patient was noted to have evidence of portal venous gas on diagnostic imaging. The case study highlights common underlying causes of portal venous gas and pneumobilia in addition to diagnostic options and findings for evaluation. The most common cause of portal venous gas is bowel necrosis. Ultrasound and computed tomography scan are the most sensitive diagnostic methods in differentiation. Being familiar with the radiographic signs of and potential underlying causes of portal venous gas and pneumobilia may allow for more prompt investigations of potentially life‐threatening underlying causes. If recent surgical manipulation to the hepatobiliary/hepatoenteric system is not present and there is no history of trauma, then further diagnostic workup should be performed to evaluate for an underlying cause. Treatment of portal venous gas and pneumobilia is based on treating the suspected underlying cause.
Licence to Regulate: Article 114 TFEU as Choice of Legal Basis in the Digital Single Market
Authors: Engel Annegret 
Published: November 2024

AbstractThis chapter discusses Article 114 TFEU as the choice of legal basis in the Digital Single Market. It argues that the EU’s competence in the internal market has developed into a default option for harmonising measures in digitalisation, exacerbated by the Union’s new regulatory approach. With particular reference to the area of competition law and the recently introduced Digital Markets Act, Article 114 TFEU might constitute the Commission’s preferred choice for pragmatic reasons, yet not necessarily undisputedly so. The chapter will present and discuss a number of pressing alternatives available from a constitutional perspective, most importantly Article 103 TFEU under the policy area of competition law. As will be argued, a lex specialis might indeed entail advantages over the generic use of horizontal legal bases, such as Article 114 TFEU, despite often being overlooked in the quest for the correct choice of legal basis. With the Digital Single Market being prone to rapid change in technologies demanding swift regulatory replies and harmonised enforcement, the role of special legal bases seems even more marginalised to the detriment of intergovernmental flexibility and the constitutional setup of competence categories as codified by the Treaty of Lisbon.
Global Power Shifting Tendencies Influenced by the Conflict’s Outcome: Regional and Global Implications
Authors: Stavytskyy Andriy 
Published: November 2024

AbstractThe initiation of military operations by Russia against Ukraine in February 2022 sparked a full-scale war in Europe, impacting the global economy and geopolitical dynamics. This chapter delves into the underlying factors that ignited the conflict, with a particular focus on Russia’s historical inclination towards expansion through warfare, its reliance on resource exports, and military capabilities, and its response to technological changes. The modern world’s decreasing reliance on resources in favour of technological development poses a challenge to resource-rich countries like Russia, leading to efforts to maintain dominance through military aggression. Russia’s economic dependence on resource exports, particularly energy, exacerbates its vulnerability to global market shifts. Understanding the multifaceted drivers of conflict is essential for addressing geopolitical tensions and fostering global stability. Mitigating the risk of future conflicts requires strategic diplomacy, economic diversification, and technological innovation to navigate evolving geopolitical landscapes.
Implementation of the European Court of Human Rights Judgements as an Instrument for Recovery of Ukraine and its Accession to the European Union
Authors: Chernohorenko Illia 
Published: November 2024

AbstractThe chapter focuses on the potential role of implementation of the European Court of Human Rights (ECtHR) judgements in Ukraine’s recovery and accession to the European Union. It first analyses pre-February 2022 challenges in implementation of the ECtHR judgements in Ukraine. It then evaluates the impact of the invasion on the implementation of the ECtHR judgements, particularly within the framework of Ukraine’s aspirations for EU accession and the recovery plan encapsulated in the Ukraine Recovery Plan. Finally, it explores the interrelations between enforcement of the ECtHR judgements in inter-State cases against Russia and establishing a special mechanism of compensation for human rights violations caused by Russian aggression.
The Digital Battlefield: Exploring the Intersection of Ukraine’s War, Digitalization and Economic Development
Authors: Stoica Eduard Alexandru , Bogoslov Ioana Andreea , O’Connor Alina 
Published: November 2024

AbstractNowadays, technological progress undoubtedly represents a competitive advantage in almost all the human being spheres of action, both at the individual and collective level. With multiple recognized beneficial influences, digital transformation is, among others, a key factor in the evolution of the modern economy and society. However, understanding the multifaceted effects of the technological tools involvement in crisis conditions requires a more in-depth approach. Thus, through the lens of Ukraine’s war experience, the present chapter aims to examine notable aspects related to the intersection of conflict, digitalization, and economic development.Exploring the perspective of the last decades, the analysis of the existing evidence depicts the undeniable efforts of Ukraine in the direction of digitalization, materialized in noteworthy results that demonstrate, among others, the benefits of technological progress in the face of situations characterized by risk and uncertainty. Under the war conditions, the use of digital resources proved to be one of the key means implied to reduce the crisis effects at multiple levels. However, the paradigmatic shift in dynamics through the use of technology has also brought new challenges, highlighting the urgent need for states to adapt their national strategies to the digital age.Finally, the analysis investigates and proposes possible policy directions and strategies to support the digital transformation of Ukraine in the short, medium, and long term. Drawing lessons from Ukraine’s experience, the obtained results support the need for a coordinated global response to address the challenges posed by the evolving nature of conflict in the digital age.