bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of long non-coding RNA ZEB1-AS1 in Chinese cancer patients
Authors: Zhou Xi , Fan Yang-Hua , Wang Yan , Wang Fu , Liu Yong 
Published: April 2019

Abstract

Background:
Aberrant expression of long non-coding RNA Zinc finger E-box binding homeobox 1 antisense 1 (lncRNA ZEB1-AS1) can be detected in numerous malignancies. Therefore, a meta-analysis had been carried out in this study, aiming to examine the prognostic value of lncRNA ZEB1-AS1 in malignancies.

Methods:
Electronic databases, such as PubMed, OVID as well as Web of Science, had been systemically retrieved from inception to February 14th, 2019. Besides, the hazard ratios (HRs), together with the corresponding 95% confidence intervals (CIs), had also been analyzed for determining the association of lncRNA ZEB1-AS1 expression with the overall survival (OS) and recurrence-free survival (RFS). In addition, the pooled odds ratios (ORs) would also be computed using the Stata SE12.0 software for evaluating the relationship of lncRNA ZEB1-AS1 expression with pathological factors.

Results:
A total of 21 original studies involving 1801 cancer patients had been enrolled into the current meta-analysis. As suggested by the pooled HR, high expression of lncRNA ZEB1-AS1 had displayed marked correlation with OS (HR = 2.16, 95% CI: 1.89–2.47) among cancer patients, and no significant heterogeneity was detected. Additionally, high expression of lncRNA ZEB1-AS1 was also markedly associated with RFS among cancer patients (pooled HR = 2.55, 95% CI: 1.61–4.03). Besides, the expression of lncRNA ZEB1-AS1 had displayed marked correlation with poor histological grade (PHG) (OR = 2.86, 95% CI: 2.11–3.87), high tumor stage (HTS) (OR = 3.81, 95% CI: 2.72–5.34) as well as lymph node metastasis (LNM) (OR = 3.33, 95% CI: 2.47–4.49). Additionally, no distinct asymmetry had been detected for RFS, PHG as well as HTS based on Begg funnel plot.

Conclusions:
Taken together, high expression of lncRNA ZEB1-AS1 can predict the dismal OS, RFS, LNM, PHG, and HTS, indicating that lncRNA ZEB1-AS1 can be potentially used as a new biomarker to predict the dismal prognosis for cancer patients.
Topiramate precipitating a manic episode in a bipolar patient comorbid with binge eating disorder
Authors: Duan Jinfeng , Lai Jianbo , Wang Dandan , Zhou Weihua , Huang Manli , Hu Shaohua , Xu Yi , Lu Jing 
Published: April 2019

Abstract

Rationale:
Topiramate is a novel antiepileptic drug that is used as an adjunctive in the treatment of partial and secondary generalized seizures. In recent years, psychiatrists have paid more attention to topiramate as a mood stabilizer and as an agent for treating eating disorders, especially in binge eating disorder (BED) and bulimia nervosa.

Patient concerns and diagnoses:
Herein, we report a case of topiramate precipitating a manic episode in a bipolar patient comorbid with BED, who complained of emotional instability and binge-eating behaviors.

Diagnoses:
In this patient, acute manic episode was induced by topiramate treatment at a daily dose of 75 mg for three days.

Interventions:
The dose of topiramate was decreased to 25 mg per day promptly, and the patient gradually became calm but the BED symptoms recurred, then the dose of topiramate was increased to 50 mg per day again. Meanwhile, the dosage of quetiapine was escalated up to 500 mg per night to stabilize her mood.

Outcomes:
With a combination of quetiapine 500 mg per night and topiramate 50 mg per day, the emotion and eating problems of this patient concurrently improved.

Lessons:
These findings indicated that patients with a history of bipolar disorder and comorbid BED have a tendency to develop manic episode when taking topiramate. Careful monitoring of mood alterations after topiramate supplement to mood stabilizers is necessary in this population.
Extradural anterior clinoidectomy and aneurysm clipping using transcranial neuroendoscopic approach
Authors: Cai Qiang , Guo Qiao , Zhang Wenfei , Ji Baowei , Chen Zhibiao , Chen Qianxue 
Published: April 2019

Abstract

Rationale:
Anterior clinoidectomy is an important technique for neurovascular and skull base surgery. Until now, extradural anterior clinoidectomies have been performed under a microscope in almost all clinical cases, with only one clinical case performed an extradural pathological anterior clinoid process resection using neuroendoscopy. Additionally, no normal ACP resections have been performed extradurally via neuroendoscopy, especially for aneurysms. We tried to perform extradural anterior clinoidectomies by neuroendoscopy.

Patient concerns:
A 63-year-old woman was admitted to hospital presented with sudden onset of headache without any accompanying neurological deficit. A computed tomography (CT) scan of the head revealed a subarachnoid hemorrhage, which was positioned mainly in the left slyvian fissure and interpeduncular and basilar cisterns.

Diagnoses:
1. Left side posterior communicating artery aneurysm; 2. subarachnoid hemorrhage.

Interventions:
Extradural anterior clinoidectomy and aneurysm clipping were performed using transcranial neuroendoscopic approaches.

Outcomes:
The patient recovered well after the procedure, and the post-operative image view revealed that the ACP had been removed and that the clip was located just at the ACP area.

Lessons:
This case provided the first evidence that extradural anterior clinoidectomy could be performed by transcranial neuroendoscopic approach.
Surgical treatment of a posterior inferior cerebellar artery aneurysm via transcranial neuroendoscopic approach
Authors: Cai Qiang , Guo Qiao , Zhang Wenfei , Ji Baowei , Chen Zhibiao , Chen Qianxue 
Published: April 2019

Abstract

Rationale:
Posterior inferior cerebellar artery (PICA) aneurysms are rare and heterogeneous in both location and morphology, and the management of proximal PICA aneurysms is challenging. In 2011, Joaquim reported a successfully treated VA-PICA ruptured aneurysm using a pure endoscopic endonasal transclival approach for the first time. However, the patient suffered CSF rhinorrhea and underwent an additional operation to repair the CSF leak. In this case report, we describe the treatment of proximal PICA aneurysm by transcranial neuroendoscopic approach.

Patient concerns:
A 68-year-old woman presented with a sudden onset of severe headache followed by loss of consciousness and computed tomography of the head showed a mild SAH, located predominantly in the posterior fossa. Clinical signs and symptoms included headache and a positive meningeal irritation sign; no other neurological symptoms were found.

Diagnosis:
A 3-dimensional CT angiography revealed the diagnosis as left VA-PICA junction aneurysm.

Interventions:
After a medical treatment, the patient regained consciousness and the aneurysm was treated by pure neuroendoscopy via a modified far-lateral surgical approach.

Outcomes:
The patient recovered well after the procedure, and the post-operation image view shows a proper placement of the clip, obliteration of the aneurysm, and the parental artery was unobstructed.

Lessons:
To our best knowledge, this is the first reported case of treating aneurysm by neuroendoscopic transcranial approach and the second reported case treated by endoscopy. In the present report, we propose that ruptured VA-PICA junction aneurysms could be treated by a pure transcranial neuroendoscopic approach. The advantages of this approach included no risk of CSF rhinorrhea compared with the endoscopic endonasal transclival approach.
A retrospective study of acupuncture as an adjunctive therapy to topical ibuprofen for chronic knee pain due to osteoarthritis
Authors: Liu Shi-Chen , Qiao Xiao-Feng , Tang Qing-Xi , Li Xiao-Guang , Yang Jian-Hua , Wang Tian-Qi , Xiao Ya-Jie , Qiao Jian-Min 
Published: April 2019

Abstract
This retrospective study investigated the effectiveness and safety of acupuncture as an adjunctive therapy to topical ibuprofen (TIP) for patients with chronic knee pain (CKP) due to osteoarthritis.
This retrospective study analyzed medical records of 84 patients with CKP due to osteoarthritis. These patients were divided into a treatment group (n = 42) and a control group (n = 42). The patients in the treatment group were treated with acupuncture plus TIP, while the subjects in the control group received TIP monotherapy. The primary effectiveness endpoint was assessed by Western Ontario and McMaster Universities osteoarthritis index (WOMAC). The secondary effectiveness endpoints were evaluated by the numeric rating scale (NRS), 12-item Short FormHealth Survey (SF-12, mainly including mental component summary [MCS], and physical component summary [PCS]), and adverse events. All patients received an 8-week treatment. All endpoints were measured pre-treatment and posttreatment.
The patients who received acupuncture plus TIP showed better effectiveness in both primary endpoint of WOMAC scale (pain, P < .01; function, P < .01; and stiffness, P < .01) and secondary endpoints of NRS (P < .01), and SF-12 (MCS, P < .01; and PCS, P < .01), than patients who received TIP monotherapy. In addition, both groups had similar safety profile.
The results of this study showed that the effectiveness of acupuncture plus TIP may be better than TIP monotherapy for patients with CKP due to osteoarthritis.
Clinical characteristics of arytenoid dislocation in patients undergoing bariatric/metabolic surgery
Authors: Hung Kuo-Chuan , Chen Yi-Ting , Chen Jen-Yin , Kuo Chuan-Yi , Wu Shao-Chun , Chiang Min-Hsien , Lan Kuo-Mao , Wang Li-Kai , Sun Cheuk-Kwan 
Published: April 2019

Abstract
Tracheal intubation and the use of a large-bore calibrating orogastric (OG) tube have been reported to increase the incidence of arytenoid dislocation (AD) in patients undergoing bariatric/metabolic surgery. This study aimed at identifying the clinical characteristics of this patient subgroup.
We retrospectively examined the clinical characteristics of 14 patients with AD (study group) who received tracheal intubation and OG insertion for bariatric/metabolic surgery between 2011 and 2016. For comparison, another group of 19 patients with postoperative AD collected from published literature and 3 patients from the authors’ institute served as controls in whom only tracheal intubation was performed. Information on patient characteristics, anesthetic time, symptoms, time of symptom onset, intervention, and postinterventional impact on vocalization of the 2 groups were collected and compared.
Patients in the study group were younger than those in the control group (38 [25–60] vs 54.5 [19–88] years, P = .03). Compared with the control group, anesthetic time (282.5 [155–360] vs 225 [25–480] minutes, P = .041) was longer and symptom onset (1.0 [0–6] vs 1.0 [0–6] days, P = .018) was more delayed in the study group. After closed reduction, the frequency of voice recovery was comparable in both groups in a time interval of 12 weeks (84.6% vs 92.9%, P = .59).
Our report demonstrates that the clinical characteristics of patients with AD who received tracheal intubation and OG insertion for bariatric/metabolic surgery were different from those with postoperative AD receiving only tracheal intubation, highlighting the importance of implementing individualized strategies for AD prevention in this patient population.
Importance of patient history in diagnosis of foreign body aspiration in children
Authors: Cui Yu , Cui Xiangyan , Yu Tingting , Zhu Zhanpeng , Wang Xin 
Published: April 2019

Abstract

Rationale:
Accidental tracheobronchial foreign body aspiration (FBA) is one of the diseases with the highest morbidity and mortality in early childhood. A history of aspiration is very important for diagnosis, as sometimes there are no abnormalities in the physical examination of the patient. Parental negligence and inappropriate treatment may be important reasons for the delay in diagnosis. We describe 2 cases of misdiagnosed children with an unclear history of aspiration.

Patient concerns:
A 5-year-old boy, who fell out of bed when sucking pistachios and landed on his neck, was initially diagnosed as a closed injury of the larynx. An 18-month-old girl, who developed a cough and difficulty breathing after she fell to the ground surrounded by many corn grains.

Diagnosis:
Bronchoscopy examination confirmed the diagnosis of tracheobronchial foreign bodies.

Interventions:
The foreign bodies were removed by bronchoscopy examination.

Outcomes:
Both patients were discharged after removal of the foreign bodies and antibiotic treatment.

Lessons:
Aspiration history is crucial for the correct diagnosis of FBA, and lack of history may lead to the misdiagnosis of FBA. Parents should be educated to increase their awareness of tracheobronchial FBA, and avoid providing their children with small objects that can potentially block the airways. When FBA is suspected, the child should be sent to a hospital immediately. Diagnostic rigid bronchoscopy is recommended.
Prognostic value of tumor necrosis in gastrointestinal stromal tumor
Authors: Yi Mengshi , Xia Lin , Zhou Yan , Wu Xiaoting , Zhuang Wen , Chen Yi , Zhao Rui , Wan Qianyi , Du Liang , Zhou Yong 
Published: April 2019

Abstract

Background and aims:
There is currently no consensus regarding the influence of tumor necrosis on the prognosis of gastrointestinal stromal tumors (GISTs). Therefore, we conducted a meta-analysis to determine the prognostic role of tumor necrosis in patients with GIST.

Methods:
PubMed, Embase, and Web of Science electronic databases were searched from their inception to March 2018. Studies reporting data on the relationship between tumor necrosis and GIST prognosis were eligible. The measure of the effect of interest was the odds ratios (ORs) with 95% confidence intervals (CIs). This study has been registered in the Prospero (number CRD42018096036).

Results:
In total, 18 studies including 2320 patients were identified. The total odds of tumor necrosis were associated with a poor GIST prognosis (OR = 5.54, 95% CI = 4.39–6.99). Subgroup analysis of different observed outcomes indicated that tumor necrosis was associated with a decreased disease-free survival (OR = 7.08, 95% CI = 4.78–10.49), recurrence-free survival (OR = 3.96, 95% CI = 2.48–6.32), and overall survival (OR = 4.29, 95% CI = 2.02–9.13). In addition, any tumor site, tumor size, follow-up time, ethnicity, different outcomes of GIST, and different degrees of positive staining of immunohistochemical markers subgroups showed a significantly increased risk of a poor prognosis.

Conclusions:
Tumor necrosis may likely predict a poorer prognosis for GIST. However, further well-designed prospective studies with large sample size are required in the future.
Tumor laterality in renal cancer as a predictor of survival in large patient cohorts
Authors: Strauss Arne , Uhlig Johannes , Lotz Joachim , Trojan Lutz , Uhlig Annemarie 
Published: April 2019

Abstract
To assess whether left and right-sided renal cell carcinoma (RCC) carry side-specific outcomes.
Surgically treated RCC patients were included from the United States Surveillance, Epidemiology and End Results database (Surveillance, Epidemiology and End Results database [SEER]; 2013 version) and the German Centre for Cancer Registry Data (ZfKD; 2000–2014). Bilateral RCC, those with missing RCC staging, follow-up time, and survival status were excluded. Cancer-specific survival (CSS) according to RCC side was compared using multivariable Cox regression.
Seventeen thousand seven hundred nine SEER patients and 41,967 ZfKD patients were included. In both datasets, patients with left-sided RCC had higher T status and more often presented with nodal positive or metastatic disease. In the SEER dataset 1258 (14.33%) patients with left-sided RCC underwent lymphadenectomy (LAD), compared to 908 (10.17%) LADs in right-sided RCC (P <.001). CSS was inferior for left-sided in both datasets after multivariable adjustment (SEER HR = 1.187, 95% CI 1.048–1.345, P = .007, P = .008; ZfKD HR = 1.155, 95% CI 1.046–1.275, P = .004).
In the SEER population, site-specific CSS differences were driven by whether or not a LAD was performed. Among SEER patients with LAD no statistically significant differences in laterality were observed (HR 1.096, 95% CI 0.8977–1.337, P = .396) whereas, in absence of LAD, CSS was shorter for individuals with left-sided tumor (HR = 1.176, 95%CI 1.002–1.38, P = .0468).
Although the overall survival difference was only marginal, left-sided RCC in surgically treated patients tends to present at more advanced stage and has in general worse CSS, especially in patients without LAD. Site-specific lymphogenic spread patterns might contribute to these findings. Further prospective studies should evaluate, whether side-adapted LAD protocols influence outcomes in RCC patients.
The influence of statins on aortic aneurysm after operation
Authors: Liao Kuang-Ming , Wang Shih-Wei , Lu Chun-Hui , Chen Chung-Yu , Huang Yaw-Bin 
Published: April 2019

Abstract
Aortic aneurysm (AA) is a disease with substantially higher health care costs and very high mortality upon rupture. Statins have a non-lipid-lowering pleiotropic mechanism that may be beneficial for AA in disease progression and improvement of AA patient outcomes. Previous studies have been conducted with some limitations and without considering immortal time bias, lag time, and adherence. The aim of our study was to analyze the effect of statin use on AA postoperation after controlling for these factors.
All postoperative patients with a diagnosis of AA in Taiwan from 2004 to 2012 were included from the National Health Insurance Research Database. We excluded patients without computed tomography within 1 year after diagnosis and those who died within 30 days after the operation. We also analyzed the medication, medication possession ratio (MPR), immortal time bias, and lag time. Statin users were defined as those using statins for more than 30 days. Primary composite outcomes included mortality, reoperation for AA and rehospitalization for AA during the study period.
Among the whole study population (n = 1633), 199/1633 (12.19%) patients were statin users, while the others (n = 1434) were not. Mortality was higher in statin nonusers than in statin users, with a mortality rate of 40% versus 22.61% (P < .0001). There was no significant difference in reoperation or rehospitalization for AA.
Statin use may be beneficial for AA patients in our observational study. Prospective randomized controlled studies are needed to define the effect of statin therapy in this population.
Increased risk of migraine in patients with psoriasis
Authors: Min Chanyang , Lim Hyoseob , Lim Jae-Sung , Sim Songyong , Choi Hyo Geun 
Published: April 2019

Abstract
Both psoriasis and migraine are associated with inflammatory diseases. However, few studies have been conducted the increased risk of migraine in psoriasis patients. The aim of this study was to identify whether the psoriasis increases the risk of migraine. This study used the national cohort study data collected by the Korean Health Insurance Review and Assessment from 2002 to 2013. Patients with psoriasis (n = 11,071) and control participants (n = 44,284) were selected and matched 1:4 by age, sex, income, region of residence, and past medical history of hypertension, diabetes, and dyslipidemia. This study used Cox-proportional hazard model for calculating hazard ratio (HR) with crude and adjusted model. Stratification by age and sex was analyzed. Migraines occurred significantly more frequently in psoriasis patients than in control participants (adjusted HR = 1.16, 95% confidence interval (CI) = 1.04–1.31, P <.05). In the stratification analysis, migraines occurred significantly more frequently in psoriasis patients than in control participants only in the group of middle-aged males (adjusted HR = 1.62 95% CI = 1.22–2.13, P = .001). In conclusion, psoriasis might increase the risk of migraine.
Prognostic factors and treatment outcomes in patients with non-ampullary small bowel adenocarcinoma
Authors: Tian Jiangfang , Liu Jiewei , Guo Chunhong , Yang Xi , Yang Yu , Gou Hongfeng , Qiu Meng , Cao Dan 
Published: April 2019

Abstract
Small bowel adenocarcinoma (SBA) is a relatively rare malignancy in gastrointestinal tumors. In addition, the difficulty of early diagnosis, its poor prognosis compared to large bowel adenocarcinoma, and inadequate treatment experiences due to lack of prospective randomized trials make it necessary to explore the characteristics of the disease for early diagnosis and treatment.
Patients diagnosed with primary malignant tumor of small intestine in West China Hospital of Sichuan University between January 2001 and 2013 were reviewed retrospectively. A total of 208 patients with SBA were selected and 160 patients with duodenal periampullary tumor were excluded. Forty-two cases of patients were finally enrolled for statistical analysis as 6 patients were lost of follow-up. The clinical characteristics, the response to treatment and their overall survival (OS) time were reviewed and analyzed.
Of the 42 patients, 11 (26.2%) primary tumors were originated from duodenum, 29 (69.0%) from jejunum, and 2 (4.8%) from ileum. All patients (64.3% male; median age, 54.7 years) included in this study underwent primary resection of the tumor to confirm final diagnosis. Three-year survival rate is 21% and 5-year survival rate is 9%. Median OS were 24.2 months (95% CI: 4.0–72.0). The univariate predictors for prognosis of SBA were as follows: age (P = .021), severe intestinal symptoms at first diagnosis (P < .001), T4 of tumor stage (P = .011), tumor size (P = .004), relatively late clinical stage (P < .001), peritoneal metastasis (P < .001), and no chemotherapy (P = .011). The multivariate predictors for poor prognosis were age of more than 60 years old (P = .035), intestinal obstruction or perforation at first diagnosis (P = .026), relatively late clinical stage (P = .000), and no chemotherapy (P = .027).
SBA was a relatively rare malignancy that was difficult for early diagnosis and treatment. Intestinal obstruction was the common clinical manifestation at first diagnosis, with a tendency of early peritoneal metastasis. Precaution of the disease in early phase, radical resection of the primary tumor while resectable, followed with in-time chemotherapy might improve prognosis and survival of patients with SBA.