bluuebunny/crossref_metadata_2025_split huggingface dataset:
Priorities for Pediatric Patient Safety Research
Authors: Hoffman James M. , Keeling Nicholas J. , Forrest Christopher B. , Tubbs-Cooley Heather L. , Moore Erin , Oehler Emily , Wilson Stephanie , Schainker Elisabeth , Walsh Kathleen E. 
Published: January 2019

BACKGROUND:
Developing a research agenda that is focused on the priorities of key stakeholders may expedite implementation and dissemination. Our objective was to identify the highest-priority patient-safety research topics among pediatric clinicians, health care leaders, and families.

METHODS:
The Children’s Hospitals Solutions for Patient Safety Network is a network of &gt;100 children’s hospitals working together to eliminate harm due to health care. Parents and site leaders responded to an open-ended, anonymous e-mail survey used to elicit research topics. A key stakeholder panel winnowed related topics and prioritized topics using Likert scale ratings. Site leaders and parents responded to a second anonymous e-mail survey and rated the importance of each topic. Health system executive interviews were used to elicit their opinions regarding top priorities for patient-safety research.

RESULTS:
The elicitation survey had 107 respondents who produced 49 unique research topics. The key stakeholder panel developed a final list of 24 topics. The prioritization survey had 74 respondents. Top-priority research topics concerned high reliability, safety culture, open communication, and early detection of patient deterioration and sepsis. During 7 qualitative interviews, health system executives highlighted diagnostic error, medication safety, deterioration, and ambulatory patient safety as priority areas.

CONCLUSIONS:
With this study, we take a first step toward a stakeholder-driven research agenda on the basis of the assumption that stakeholders are best positioned to determine what research will be used to address the problems of most concern to them.
Sol-gel synthesis and crystal chemical properties of the pigment Zn1.9Cu0.1SiO4
Authors: Samigullina R. F. , Rotermel M. V. , Ivanova I. V. , Krasnenko T. I. 
Published: January 2019

The pigment Zn1.9Cu0.1SiO4 was obtained by the method of sol-gel synthesis. The crystallization temperature was set at 776 °C, ∆H ≈ -16.3 kJ/mol. Thermal expansion of the individual Zn2SiO4 and Zn1.9Cu0.1SiO4 solid solutions was studied by in situ high-temperature X-ray diffraction. It is shown that the substitution of Zn2+ → Cu2+ does not lead to significant changes in the lattice parameters; in the range from room temperature to 800 °C the structure expands monotonically when heated. The coefficients of volumetric thermal expansion for Zn2SiO4 and Zn1.9Cu0.1SiO4 are αV = 8.05 · 10-6 and 8.81 · 10-6 1/K, respectively. The colorimetric coordinates in the RGB system are 71.8% red, 72.9% green and 79.6% blue, which corresponds to the gray-blue pigment.
"Big trifles" of advanced liver resections for alveococcosis
Authors: Zagaynov V. E. , Kiselev N. M. , Belskiy V. A. , Rykhtik P. I. , Bobrov N. V. 
Published: January 2019

Aim. Analysis of the techniques of advanced liver resections involving transplantation technologies which affect the results of surgery for advanced liver alveococcosis.Material and methods. There were 65 patients with massive complicated liver alveococcosis for the period from 2008 to 2018. Radical procedures were applied in 82% of cases (n = 53). Mechanical jaundice was observed in 45% ofpatients, portal hypertension — in 25%. Previous palliative surgery was applied in 58% of patients. Thirty-three patients (50.8%) had advanced parasitic lesion with involvement of afferent and (or) efferent vascular structures. Distant metastases were detected in 6 patients: metastatic lung lesions occurred in 5 of them, simultaneous injury of brain and lungs — in 1 case.Results. There were 47 RO-resections with application of transplantation technologies including 4 extracorporeal resections and 6 orthotropic liver transplantations. Reconstruction of great afferent and efferent vascular structures was performed in 47% of cases: IVC repair — 25 cases, PV repair — 25 cases. Resection of extrahepatic bile ducts was made in 33 cases. Postoperative complications occurred in 26 cases: Clavien-Dindo type II — 5, IIIb — 13, IVb — 2, V — 6. Bile leakage ISGLS class B occurred in 6 cases, class C — in 11 cases.Conclusion. Transplantation technologies for advanced liver resections and liver or its segment transplantation allow to achieve radical surgery in 82% of patients. Advanced operations are indicated for advanced liver alveococcosis due to good outcomes. There are various technical aspects of such operations which are useful to avoid most of complications.
Analysis of the hepatic vessels structure in potential liver donors
Authors: Bayguisova D. Z. , Battalova G. A. , Mukhamedzhanova A. N. , Naumenko Yu. A. , Olzhabayeva A. K. , Baymakhanov B. B. , Baymakhanov Zh. B. 
Published: January 2019

Aim. To analyze anatomic variants of arterial and venous blood supply of liver in potential liver donors by using of CT-angiography (CTA).Material and methods. CTA data of 151 potential donors have been examined for the period 01.01.2016-01.01.2018. Non-ionic iodine-containing (320 mg/ml) contrast agent was used at a dose of 1.4 ml/kg and infusion rate near 4.0 ml/s. Variants of arterial anatomy were classified according to N. Michels, portal vein anatomy — according to T Nakamura classification (2002).Results. N. Michels type I was the most common variant of arterial structure (n = 108, 71.5%). Types II and III were observed in 8.6% and in 7.9% of cases, respectively. Types IV and IX included the same number of donors (2.6%). Types VII and VIII were the rarest (0.7% and 1.3%). Types V, VI, X were absent. There were 7 cases (4.6%) with arterial variants which are not described by N.Michels classification. Moreover, 3 types were not previously described by other authors.Conclusion. Hepatic artery variations coincide with the classification of N. Michels as a rule (95.4%). Other anatomic variants not described in this classification were observed only in 4.6% of cases.
Growth and yield parameters of three cowpea (Vigna unguiculata L. Walp) lines as affected by planting date and zinc application rate
Authors: Mfeka Nonkululeko , Mulidzi Reckson A. , Lewu Francis B. 
Published: January 2019

Cowpea is one of the most important food legumes in most African countries. Cowpea is a valuable source of dietary protein for both humans and their livestock. There is limited information available on cowpea production and suitable agronomic practices, such as planting date, to best suit different environmental conditions in South Africa. Therefore, the objective of this study was to evaluate the effect of two locations on cowpea production and the effect of planting date as affected by zinc application rate. Field experiments were conducted at two locations (Bien Donne’ and Nietvoorbij) in the Western Cape Province of South Africa, using two planting dates (2 October and 2 November), three cowpea lines (Veg1, M217 and Qukawa) and three zinc (Zn) fertiliser application levels (0 kg/ha, 15 kg/ha and 30 kg/ha) during the 2015 growing season. The experimental design was a randomised complete block with five replicates. The results showed that Veg1 and Qukawa lines performed significantly better in both vegetative and reproductive parameters when compared to M217 at both locations. Application of zinc fertiliser significantly (p<0.05) affected seed iron content in Veg1 and M217 at Bien Donne’ and seed iron content in M217 and zinc content in Veg1 at Nietvoorbij.
Significance:

Cowpea lines Veg1 and Qukawa were the best performing lines in all parameters measured, making these two lines suitable for dual purpose cultivation.
Planting cowpea in November, rather than October, increased the crop production efficiency.
Cowpea showed a better overall total yield in the sandy soil of Bien Donne’ than in the sandy loam clay soil of Nietvoorbij.

Open data set:
https://osf.io/u4veb/?view_only=45d90f5cd93949fb90cd0ee45055f92c
Palaeotopography of a Palaeolithic landscape at Bestwood 1, South Africa, from ground-penetrating radar and magnetometry
Authors: Papadimitrios Konstantinos S. , Bank Carl-Georg , Walker Steven J. , Chazan Michael 
Published: January 2019

In order to investigate the buried landscape at the Fauresmith locality of Bestwood 1, outside the town of Kathu in the Northern Cape Province, we performed ground-penetrating radar and magnetometry surveys across the sand-filled central portion of the valley. The radar images a strong continuous reflector which we can assign to the boundary between the Kalahari sands and underlying Banded Ironstone Formation gravels. Moreover, the thickness of the sand delineates a buried depression in the centre of the valley with flat plateaus at the sides. Subtracting the sand thickness from the current topography produces a map of a small stream channel in the northern part of the valley. Analysis of the magnetic gradient data allows us to extend this buried channel further to the south. Our geophysical survey provides a valuable contribution towards understanding the context of hominin occupation along the banks of a small stream in the Kathu Complex.
Significance:

We provide an example of combining two geophysical methods to map overburden thickness, useful for archaeological landscape interpretation.

.
Nohut (Cicer arietinum L.)’ta Solgunluğa Neden Olan Fusarium oxysporum’un Biyolojik Mücadelesi
Authors: AYDIN Mehmet Hadi 
Published: January 2019

Bu çalışma, nohut solgunluk hastalığına neden olan Fusarium oxysporum’a karşı bazı Trichoderma
türlerinin etkinliğini belirlemek amacıyla 2017-2018 yılları arasında in vivo
ve in vitro koşullarında yürütülmüştür. F. oxysporum’un N5 ve N7 izolatına karşı, PDA
besiyerinde, ikili kültür yöntemine göre,
22 ± 24 oC’de yürütülen denemede, en etkili izolatlar
sırasıyla T. hamatum ÖT 16, T. asperellum ÖT1, T. strigosum LO43, T. gamsii VG47 ve T. gamsii VG48 olarak belirlenmiştir. İn vivo koşullarında ise,
bulaşık saksı toprağında, nohut tohumlarına antagonist uygulayarak yürütülmüştür.
Trichoderma’ların nohut solgunluk
patojenlerini farklı oranlarda etkilediği, en etkili izolatların ise sırasıyla T. hamatum ÖT16, T.viride VG18, T. gamsii VG47
olduğu tespit edilmiştir. Çalışmada, nohut solgunluk hastalığına karşı
biyolojik mücadelede, Trichoderma’ların etkili olduğu sonucuna
varılmıştır.
PRODIG (Prevention of new onset diabetes after transplantation by a short term treatment of Vildagliptin in the early renal post-transplant period) study study protocol for a randomized controlled study
Authors: Gaiffe Emilie , Crepin Thomas , Bamoulid Jamal , Courivaud Cécile , Büchler Matthias , Cassuto Elisabeth , Albano Laetitia , Chemouny Jonathan , Choukroun Gabriel , Hazzan Marc , Kessler Laurence , Legendre Christophe , Meur Yannick Le , Ouali Nacera , Thierry Antoine , Anota Amélie , Nerich Virginie , Limat Samuel , Bonnetain Franck , Vernerey Dewi , Ducloux Didier 
Published: January 2019

Abstract
Background: Post-transplant diabetes is a frequent and serious complication of kidney transplantation. There is currently no treatment to prevent or delay the disease. Nevertheless, identification of risk factors make possible to target a population at risk to develop de novo diabetes. We hypothesized that a short term treatment with Vildagliptin may prevent new onset diabetes after transplantation (NODAT) in high-risk patients.
Methods: This is a multicenter double-blind placebo-controlled randomized clinical trial. Patients undergoing first kidney transplantation will be included in 10 French transplant center. Included patients will be randomized (1:1) to receive either vildagliptin 100 or 50 mg/day (depending on glomerular filtration rate) during 2 months (the first dose being administered before entering the operating blocks) or placebo. Additional antidiabetic therapy could be administered according to glycemic control. The primary outcome is the proportion of diabetic patients 1 year after transplantation, defined as patients receiving a diabetic treatment, or having a fasting glucose above 7 mmol/l, or/and with an abnormal oral glucose tolerance test. Secondary outcomes include the glycated hemoglobin, the occurrence of acute rejection, infection, graft loss and patient death at 3 months, 6 months and 12 months after transplantation. The results will be correlated to clinical and general characteristics of the patient, cardiovascular history, nephropathy, dialysis history, transplantation data, biological data, the health-related quality of life and the cost-effectiveness of prevention of diabetes with vildagliptin.
Discussion: There are only few data concerning pharmacological prevention of post-transplant diabetes. If our hypothesis is verified, our results will have a direct application in clinical practice and could limit diabetes-associated morbidity, reduce cardiovascular complications, increase quality of life of renal transplant patients, and consequently promote graft and patient survival. Our results may possibly serve for non-transplant patients carrying a high-risk of diabetes associated with other co-morbidities.
Trial registration: ClinicalTrials.gov, NCT02849899 Registered on 8 February 2016.
Keywords: Diabetes prevention; Vildagliptin; kidney transplantation; randomized controlled trial.
A patient with epilepsy suffering from repeatedly hyperbilirubinemia caused by Gilbert Syndrome: a case report and literatures review
Authors: Zhang Yao-yao , Jiang Yong-li , Song Chang-geng , Zhao Zhi-han , Yuan Fang , Yang Fang , Jiang Wen 
Published: January 2019

Abstract
Background: Certain antiepileptic drugs (AEDs) such as valproic acid (VPA) and lamotrigine (LTG) would bring some abnormalities on liver function, ranging from mild malfunction of liver tests to serious hepatotoxicity. The former manifests temporary and reversible elevation of bilirubin and liver enzyme, which is usually dose-dependent and the abnormality can return to normal shortly after the drug was withdrawn. Levetiracetam (LEV), as a newly broad-spectrum AED with relatively fewer side-effects and fewer drug interactions, is increasingly used as adjunctive therapy to treat generalized epilepsy. Gilbert syndrome（GS）is characterized by mild, chronic, intermittent unconjugated hyperbilirubinemia without other hepatic diseases. Fasting, stress, along with some liver toxic drugs would make it clinically apparent. However, when GS co-exists with epilepsy, how to differentiate which one is responsible for the abnormality of bilirubin poses a challenge to us. We herein describes a patient with epilepsy complicated by mildly and intermittently elevated bilirubin, and after various examinations especially for whole-exome sequencing（WES）and liver biopsy, we made a definite diagnosis of GS.
Case presentation: A 25-year-old male with epilepsy suffering from intermittently and mildly elevated bilirubin, and relevant imaging information led us consider the diagnosis of idiopathic generalized epilepsy (IGE). After administration of AEDs, the indirect bilirubin remained still slightly elevated even while taking LEV. Then he was referred to the department of gastroenterology in our hospital, the results of diagnostic tests, clinical manifestation, imaging studies, WES and liver biopsy all made contributions to our diagnosis of GS rather than the hepatic injury induced by AEDs.
Conclusions: This report presents us with a case of an epilepsy patient complicated by repeatedly elevated bilirubin and finally was diagnosed with GS. By referring to literatures and genetic testing, though, no shared genetic and pathophysiological basis between epilepsy and GS was found, and enzymes responsible for the metabolism of AEDs took no part in the pathogenesis of GS. Our experiences will help clinicians to better differentiate the etiology of repeatedly elevated bilirubin of epilepsy patients during the process of treatment.
Key words: Epilepsy, Gilbert syndrome, Valproic acid, Lamotrigine, Levetiracetam, hyperbilirubinemia.
Effectiveness of Yi-Zhi-An-Shen Granules on cognition and sleep quality in older adults with amnestic mild cognitive impairment: protocol for a randomized, double-blind, placebo-controlled trial
Authors: Yue Shengnan , He Ting , Li Baiyang , Qu Yanqin , Peng Hongmei , Chen Jinxin , Lei Ming , Chen Chongli , Wu Wenbin 
Published: January 2019

Abstract
Background: Amnestic mild cognitive impairment (aMCI) is a syndrome characterized by significant forgetfulness that does not meet the criteria of dementia. Individuals with aMCI are at a bigger risk of progressing to dementia. Current studies suggest good sleep quality is linked with preserved cognition in the elderly, and sleep complaints are common among the elderly with amnesia. Therefore, improving their sleep may be helpful for maintaining and improving their cognitive capacity. According to the theory of traditional Chinese medicine, Yi-Zhi-An-Shen is an herbal compound which may ameliorate forgetfulness and sleep disorders. As growing evidence indicates that gut microbiome is associated with major mental symptoms, a hypothesis was proposed that Yi-Zhi-An-Shen Granules (YZASG) might work by alternating microbial abundance and diversity. In this study, the investigators intend to assess the efficacy of YZASG on global cognition in the elderly suffering from aMCI, and evaluate its safety as well as its potential mechanisms via sleep quality, fecal microbial 16SrDNA and metagenomics analyses, and serum markers.
Methods: This is a randomized, double-blind, placebo-controlled clinical trial. A total of 80 patients (aged 60~85 years) will be recruited and allocated randomly to a treatment group and a placebo-matched group in a 1:1 ratio, then will be administered YZASG or isodose placebo three times a day. The intervention course is 16 weeks, with an 18-month follow-up. The primary outcome is Alzheimer Disease Assessment Scale-Cognitive subscale (ADAS-cog11). Secondary outcome measures are mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), Pittsburgh Sleep Quality Index (PSQI), serum concentrations of immunological factors and inflammatory cytokines, fecal microbiota. Fecal microbiota will only be collected at the baseline and endpoint of the intervention.
Discussion: The results of this trial will be conducive to assessing the safety and effectiveness on cognition of YZASG in intervening aMCI among the elderly and determining if it takes effect via the improvement of sleep quality, regulation of gut microbita, concentration of certain serum markers.
Trial Registration: ClinicalTrials.gov, ID: NCT03601000. Registered on 26 July 2018.
Keywords: Amnestic Mild cognitive impairment (aMCI), Sleep, Gut microbiome, Older adults
Pathogenic Genes Selection Model of Genetic Disease based on Network Motifs Slicing Feedback
Authors: Zhang Shengli , Tong Zekun , Yin Haoyu , Feng Yifan 
Published: January 2019

Background:
Finding the pathogenic gene is very important for understanding the pathogenesis
of the disease, locating effective drug targets and improving the clinical level of medical treatment.
However, the existing methods for finding the pathogenic genes still have limitations, for instance
the computational complexity is high, and the combination of multiple genes and pathways has
not been considered to search for highly related pathogenic genes and so on.

Methods:
We propose a pathogenic genes selection model of genetic disease based on Network Motifs
Slicing Feedback (NMSF). We find a point set which makes the conductivity of the motif minimum
then use it to substitute for the original gene pathway network. Based on the NMSF, we propose a new
pathogenic genes selection model to expand pathogenic gene set.

Results:
According to the gene set we have obtained, selection of key genes will be more accurate and
convincing. Finally, we use our model to screen the pathogenic genes and key pathways of liver cancer
and lung cancer, and compare the results with the existing methods.

Conclusion:
The main contribution is to provide a method called NMSF which simplifies the gene
pathway network to make the selection of pathogenic gene simple and feasible. The fact shows our result
has a wide coverage and high accuracy and our model has good expeditiousness and robustness.
HAMBATAN PENDIDIKAN KARAKTER DI SEKOLAH ISLAM TERPADU (STUDI KASUS SDIT AL HASNA KLATEN)
Authors: Agustinova Danu Eko 
Published: January 2019

Penelitian ini bertujuan untuk menganalisis hambatan yang dialami dalam menanamkan nilai-nilai karakter kepada peserta didik di Sekolah Islam Terpadu. Dimana pada model sekolah ini, pendidikan karakter telah dilaksanakan lebih awal sejak kelahiran model sekolah tersebut. Penelitian ini dilakukan di SDIT Al Hasna Klaten. Metode penelitian ini adalah kualitatif deskriptif dengan strategi yang digunakan adalah studi kasus tunggal. Cuplikan yang digunakan dalam penelitian ini adalah purposive sampling dengan criterion-based selection. Pengumpulan data dilakukan dengan observasi langsung, wawancara mendalam, dan pencatatan dokumen. Validasi data dilaksanakan dengan trianggulasi. Analisis data yang digunakan adalah model analisis interaktif, yaitu pengumpulan data, reduksi data, sajian data dan penarikan kesimpulan. Hasil penelitian ini menyimpulkan bahwa Hambatan yang dialami dalam proses penanaman karakter berasal dari dalam dan dari luar. Hambatan dari dalam meliputi pendidik yang kurang bisa memahami karakteristik masing-masing siswa. Kurangnya sarana penunjang dalam kegiatan pembelajaran. Selain itu, sistem full day itu sendiri yang ternyata memiliki beberapa kelemahan. Sedangkan, hambatan dari luar adalah kurang partisipasi aktif orang tua dalam proses penanaman karakter. Kata Kunci: Pendidikan Karakter, Hambatan, SDIT Al Hasna.
PERSAINGAN ELIT BANGSAWAN DENGAN KELOMPOK TERDIDIK PADA MASA REVOLUSI DI SULAWESI SELATAN
Authors: Najamuddin Najamuddin 
Published: January 2019

Penelitian ini bertujuan untuk: (1) Mengetahui latar belakang munculnya elit bangsawan dan kelompok terdidik, (2) Mengungkapkan Konflik antara elit bangsawan dengan kelompok terdidik yang berimplikasi pada peran keduanya di Masa Revolusi di Sulawesi Selatan. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian sejarah. Tahapan dalam penelitiannya yaitu pemilihan topik, mengumpulkan sumber, kritik sumber, interpretasi, dan historiografi. Hasil penelitian menunjukkan bahwa Stratifikasi sosial masyarakat Bugis-Makassar telah memberikan posisi istimewa terhadap kaum bangsawan sebagai elit strategis dari kelompok masyarakat lainnya dalam struktur sosial, dan sebagai pemimpin puncak dalam struktur politik atau struktur kekuasaan. Ketika elit terdidik tampil dalam Pergerakan Nasional di Sulawesi Selatan bersama elit bangsawan, politik kolonial Belanda berhasil mempolarisasi keduanya menjadi bagian yang terpisah menjadi konflik di awal kemerdekaan RI. Kata Kunci: Elit Bangsawan, Kelompok Terdidik, dan Revolusi di Sulawesi Selatan
KIPRAH AMIR SYARIFFUDIN DALAM POLITIK DAN PEMERINTAHAN SAMPAI TAHUN 1948
Authors: Aman Aman , Zulkarnain Zulkarnain , Ragil Wahyu 
Published: January 2019

Penelitian ini bertujuan untuk mengetahui kiprah politik Amir Syariffudin pada pemerintahan dan setelah berakhirnya pemerintahanya 1945-1948. Metode yang digunakan peneliti dalam penulisan sejarah ini adalah metode penelitian menurut Kuntowijoyo. Adapun tahapan penelitian sejarah menurut Kuntowijoyo mempunyai lima tahap yaitu pemilihan topik, heuristik, verifikasi, interpretasi, dan penulisan. Hasil penelitian menunjukkan bahwa Amir Syariffudin memiliki peran yang sangat besar bagi Republik Indonesia. Ia memiliki andil yang besar dalam dinamika pemerintahan Republik Indonesia. Sebagai seorang nasionalis, ia pernah menduduki berbagai jabatan penting. Adapun jabatan penting tersebut antara lain: sebagai menteri penerangan, menteri keamanan, perdana menteri, dan wakil Indonesia dalam Perjanjian Renville. Kata Kunci: Amir Syariffudin, peran, politik, dan pemerintahan.