bluuebunny/crossref_metadata_2025_split huggingface dataset:
Negative Affect and Risk of Atrial Fibrillation: MESA
Authors: Garg Parveen K. , O'Neal Wesley T. , Diez‐Roux Ana V. , Alonso Alvaro , Soliman Elsayed Z. , Heckbert Susan 
Published: December 2018

Background

Current literature examining the prospective relationship between depression and other measures of negative affect with atrial fibrillation (AF) are limited. We determined the relationships of depression, anger, anxiety, and chronic stress with incident
AF
in a multiethnic cohort of middle‐ and older‐aged adults.

Methods and Results

This analysis included 6644 MESA (Multi‐Ethnic Study of Atherosclerosis) study participants who were free of
AF
at baseline. Depressive symptoms were assessed at baseline and defined as either a 20‐item Center for Epidemiologic Studies Depression Scale score ≥16 or use of antidepressant medications. The Spielberger Trait Anger Scale, Spielberger Trait Anxiety Scale, and Chronic Burden Scale were also administered at baseline to assess anger, anxiety, and chronic stress, respectively. The primary outcome was incident
AF
, identified by follow‐up study visit ECGs, hospital discharge diagnoses, or Medicare claims data. A total of 875 (13%) incident
AF
cases were detected over a median follow‐up of nearly 13 years. A Center for Epidemiologic Studies Depression Scale score ≥16 (referent, Center for Epidemiologic Studies Depression Scale score <2) and antidepressant use were associated with a 34% and 36% higher risk of
AF
, respectively, in separate adjusted Cox proportional hazards analyses (hazard ratio, 1.34; 95% CI 1.04–1.74 for Center for Epidemiologic Studies Depression Scale ≥16; hazard ratio, 1.36; 95%
CI
, 1.04–1.77 for antidepressant use). No significant associations were observed for anger, anxiety, or chronic stress with development of
AF
.

Conclusions

Depressive symptoms are associated with an increased risk of incident
AF
. Further study into whether improving depressive symptoms reduces
AF
incidence is important.
Cardiovascular Diseases Deaths Attributable to High Sodium Intake in Shandong Province, China
Authors: Zhang Jiyu , Guo Xiaolei , Lu Zilong , Tang Junli , Li Yichong , Xu Aiqiang , Liu Shiwei 
Published: December 2018

Background

High sodium intake elevates blood pressure and thereby raises cardiovascular diseases (
CVD
s). Sodium intake is high in northern China, including Shandong province where the SMASH (Shandong‐Ministry of Health Action on Sodium and Hypertension) is currently underway.

Methods and Results

Blood pressure values and sodium intake measurements using 24‐hour urinary excretion were collected from the 2011
SMASH
baseline survey, which was conducted in 20 counties/districts using a multistage stratified cluster random sampling method. We derived cause‐specific mortality from the Shandong Death Registration System (
SDRS
) during the same year and used population‐attributable fraction to estimate annual
CVD
s deaths attributable to high sodium intake (mediated through elevated systolic blood pressure) and
CVD
deaths averted by achieving different sodium‐reduction targets. Overall, 16 100 (95% uncertainty intervals, 11 000–22 600)
CVD
deaths among adults aged 25 to 69 years, including 5600 (4000–6500) for ischemic heart disease and 9000 (6700–11 600) for stroke, were attributable to higher sodium intake (2000 mg/day or 5.0 g/day of salt as a reference) in Shandong in 2011, accounting for 19.9% (13.7–25.0%) of total
CVD
deaths. The benefit of
CVD
deaths from sodium reduction is considerable with 8800 (6400–13 600), 6700 (4900–11 600), and 8500 (6000–10 800) averted, respectively, if sodium intake was reduced from the 2011 baseline to 3500 mg/day, 4000 mg/day, or reduced by 30%.

Conclusions

Nearly 20% of
CVD
deaths among adults aged 25 to 69 years could be attributable to the systolic blood pressure–raising effect of high sodium intake in Shandong in 2011. Potential benefits from population reduction of sodium intake are considerable.
Urban Influences on the Spatiotemporal Characteristics of Runoff and Precipitation during the 2009 Atlanta Flood
Authors: Debbage Neil , Shepherd J. Marshall 
Published: December 2018

AbstractThe 2009 Atlanta flood was a historic event that resulted in catastrophic damage throughout the metropolitan area. The flood was the product of several hydrometeorological processes, including moist antecedent conditions, ample atmospheric moisture, and mesoscale training. Additionally, previous studies hypothesized that the urban environment of Atlanta altered the location and/or overall quantities of precipitation and runoff that ultimately produced the flood. This hypothesis was quantitatively evaluated by conducting a modeling case study that utilized the Weather Research and Forecasting Model. Two model runs were performed: 1) an urban run designed to accurately depict the flood event and 2) a nonurban simulation where the urban footprint of Atlanta was replaced with natural vegetation. Comparing the output from the two simulations revealed that interactions with the urban environment enhanced the precipitation and runoff associated with the flood. Specifically, the nonurban model underestimated the cumulative precipitation by approximately 100 mm in the area downwind of Atlanta where urban rainfall enhancement was hypothesized. This notable difference was due to the increased surface convergence observed in the urban simulation, which was likely attributable to the enhanced surface roughness and thermal properties of the urban environment. The findings expand upon previous research focused on urban rainfall effects since they demonstrate that urban interactions can influence mesoscale hydrometeorological characteristics during events with prominent synoptic-scale forcing. Finally, from an urban planning perspective, the results highlight a potential two-pronged vulnerability of urban environments to extreme rainfall, as they may enhance both the initial precipitation and subsequent runoff.
Historical and Future Changes in Asset Value and GDP in Areas Exposed to Tropical Cyclones in China
Authors: Ye Mengqi , Wu Jidong , Wang Cailin , He Xin 
Published: December 2018

AbstractTropical cyclones (TCs) can wreak havoc on the landscape and overwhelm communities. Since economic exposure is an important factor in damage function, an evaluation of economic exposure is essential because the characteristics of TC-related hazards are changing under accelerating economic development patterns. Here, we first reconstructed the wind and rainfall fields of historical TCs through an extensive database to extract the economic exposure to TC-prone areas on the mainland of China. We found that rainfall is an important factor in determining the affected extent of a TC event and that economic exposure will be misestimated when considering only the wind field. The results reveal that economic exposure to TCs has increased considerably from 1990 to 2015 and will continue to increase until the year 2100 under shared socioeconomic pathways (SSPs). We found that 66.7% of China’s gross domestic product [GDP; CNY 48.6 trillion (7.8 trillion U.S. dollars)] and 63.9% of China’s asset value [CNY 139.5 trillion (22.4 trillion U.S. dollars)] were concentrated in TC-prone areas in 2015 and increased at an average annual rate of 10.6% and 13.9%, respectively. Projections of GDP scenarios under SSPs revealed continued growth in the early twenty-first century, and the range of GDP and asset value in TC-prone areas by 2100 varied. Further detailed studies are needed to provide a detailed damage function for TC loss assessments under climate change and to consider how TC hazards will interact under changes in exposure and vulnerability related to economic development and social change.
Delayed open conversion after endovascular aortic repair
Authors: Law Y , Chan YC , Cheng SW 
Published: December 2018

Aim We present the clinical outcomes of patients who underwent delayed (>30 days) open surgical repair after endovascular aortic aneurysm repair. Methods All patients receiving delayed open repair of infrarenal and juxtarenal aortic aneurysms after endovascular repair from July 2001 to December 2017 were retrospectively reviewed. Patients’ baseline characteristics, indications for delayed open conversion, and time between endovascular repair and open conversion are described. Early outcomes included operative approach, morbidity, and mortality. Midterm outcomes included survival. Results Twenty-two (3.3%) of 667 patients with prior infrarenal endovascular aortic aneurysm repair had delayed open conversion (20 elective and 2 emergency). The time from endovascular repair to open conversion was 60 ± 36 months. The indications were 6 (27%) type Ia endoleaks, 6 (27%) type II endoleaks with enlarging sac size, 2 (9%) endotensions, 7 (32%) unknown types of endoleak, and 1 (5%) graft infection. The 7 minutes unknown endoleaks were confirmed as lumbar leaks in 4 cases and fabric leaks in 3. Operative time was 222 ± 48 min with blood loss of 2211 ± 2057 mL. Hospital stay after conversion was 12 ± 8 days. There was no 30-day mortality. Estimated survival rates were 96%, 91%, 86%, 79% and 57% at 1, 2, 3, 4, and 5 years postoperatively. Conclusion Delayed conversion to open surgery after endovascular aortic aneurysm repair by endograft explantation appears to be safe with good short- and mid-term outcomes. With careful preoperative assessment, open conversion remained a realistic and viable option in patients with failed endovascular treatment.
Long-term quality of life in patients treated with extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock
Authors: Norkiene Ieva , Jovaisa Tomas , Scupakova Nadiezda , Janusauskas Vilius , Rucinskas Kestutis , Serpytis Pranas , Laurusonis Kestutis , Samalavicius Robertas 
Published: December 2018

Objective: The aim of our study was to explore long-term health-related quality of life (HRQOL) and incidence of post-traumatic stress disorder (PTSD) in extracorporeal membrane oxygenation (ECMO) survivors. Methods: Single-center prospective follow-up study. All patients in whom ECMO was initiated due to refractory cardiogenic shock between 2009 and 2014 were included in the study. We used Medical Outcomes Study 36-Item Short-Form Health Survey to evaluate HRQOL and IES-R questionnaire to assess incidence of PTSD. Results: Sixty-nine patients were treated with venoarterial (VA) ECMO during the study period. Nineteen patients survived until hospital discharge and 15 patients were alive at the study cut-off point in June 2017; mean follow-up time was 70.6 ± 10 months. The average Physical Component Summary and Mental Component Summary scores amongst long-term survivors were 46.1 ± 7 and 47.1 ± 8, respectively. PTSD was evident in 4 out of 15 participants. Conclusions: Despite the complex clinical course and prolonged recovery, ECMO survivors achieved satisfactory levels of both mental and physical recovery, which were comparable to the age- and pathology-adjusted population means.
Validation of the Spanish version of the Oxford Cognitive Screen (S-OCS): psychometric properties of a short cognitive stroke-specific screening tool
Authors: Valera-Gran Desirée , López-Roig Sofía , Hurtado-Pomares Miriam , Peral-Gómez Paula , García-Manzanares María , Sunyer Catlla Marta , Más Sesé Gemma , Navarrete-Muñoz Eva María , Sánchez-Pérez Alicia 
Published: December 2018

Objective: The aim of this study is to examine the psychometric properties of the Spanish version of the Oxford Cognitive Screen in a subacute stroke population. Participants and setting: Fifty-seven subacute stroke outpatients and 54 healthy individuals were recruited in Alicante province, Spain. Main measure: The Oxford Cognitive Screen. Other measures: The Montreal Cognitive Assessment, the Barcelona test, and the Barthel Index. Design: A validation study was conducted to analyze the inter-rater, intra-rater, test–retest, and internal consistency of the Spanish version of the Oxford Cognitive Screen. Concurrent validity was assessed using the Montreal Cognitive Assessment and the Barcelona test, and divergent validity using the Barthel index. Discriminant indices such as the sensitivity, specificity, predictive values, and optimal cut-offs were also estimated. Results: The subtests of the Spanish version of the Oxford Cognitive Screen showed excellent estimates for the inter-reliability (intraclass correlation coefficient (ICC) = 0.790 to 1.000; rs = 0.693 to 1.000), and acceptable-good for intra-reliability (ICC = 0.181 to 0.990) and test–retest reliability ( rs = 0.173 to 0.971). Internal consistency was also excellent (standardized Cronbach’s α = 0.907). Spearman correlations for the concurrent validity were low-strong ( rs = −0.193 to 0.95) and low-moderate ( rs = −0.091 to 0.443) for divergent validity. The optimal cut-offs estimated for the subtests of the Spanish version of the Oxford Cognitive Screen showed good-high specificity (66.7%–100%) and positive predictive value (67.9%–100%), and low-good sensitivity (14.8%–83.3%) and moderate-good negative predictive value (53.5%–76.6%). Discriminant power as measured by the area under the curve indicated acceptable-good values (0.397 to 0.894). Conclusion: Our findings support that the Spanish version of the Oxford Cognitive Screen is a reliable and valid tool for screening cognitive impairments in subacute stroke patients.
A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood–brain barrier under flow
Authors: Mossu Adrien , Rosito Maria , Khire Tejas , Li Chung Hung , Nishihara Hideaki , Gruber Isabelle , Luke Emma , Dehouck Lucie , Sallusto Federica , Gosselet Fabien , McGrath James L , Engelhardt Britta 
Published: December 2018

Here we report on the development of a breakthrough microfluidic human in vitro cerebrovascular barrier (CVB) model featuring stem cell-derived brain-like endothelial cells (BLECs) and nanoporous silicon nitride (NPN) membranes (µSiM-CVB). The nanoscale thinness of NPN membranes combined with their high permeability and optical transparency makes them an ideal scaffold for the assembly of an in vitro microfluidic model of the blood–brain barrier (BBB) featuring cellular elements of the neurovascular unit (NVU). Dual-chamber devices divided by NPN membranes yield tight barrier properties in BLECs and allow an abluminal pericyte-co-culture to be replaced with pericyte-conditioned media. With the benefit of physiological flow and superior imaging quality, the µSiM-CVB platform captures each phase of the multi-step T-cell migration across the BBB in live cell imaging. The small volume of <100 µL of the µSiM-CVB will enable in vitro investigations of rare patient-derived immune cells with the human BBB. The µSiM-CVB is a breakthrough in vitro human BBB model to enable live and high-quality imaging of human immune cell interactions with the BBB under physiological flow. We expect it to become a valuable new tool for the study of cerebrovascular pathologies ranging from neuroinflammation to metastatic cancer.
Measuring quality of Life among Colorectal Cancer Patients in Jordan
Authors: Mhaidat Nizar M. , Al-Wedyan Tahani J. , Alzoubi Karem H. , Al-Efan Qais M. , Al-Azzam Sayer I. , Balas Qosay A. , Bataineh Ziad A. 
Published: December 2018

Quality of life among colorectal cancer (CRC) patients was evaluated using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) C30 and EORTC QLQ-CR29. We interviewed 74 CRC patients, and our results indicated lower anxiety functional scores and higher abdominal pain and embarrassment symptom scores among patients aged 55 and under. Patients with disease metastasis showed significantly lower global health scores and higher fatigue, loss of appetite, hair loss, and change in taste symptom scores. Scores for emotional functioning were significantly lower among patients with stage IV disease. Fatigue, nausea and vomiting, loss of appetite, abdominal pain, and change in taste symptom scores were significantly higher in patients treated with a combination of surgery and chemotherapy compared to surgery alone. Age, disease metastasis, late disease stage, and combined treatment modalities were associated with lower scores on health-related quality-of-life scales; patients likely to have low scores on these measures should receive special attention from healthcare providers and be targeted by supportive care strategies. Nous avons évalué la qualité de vie de patients atteints du cancer colorectal à l'aide du Questionnaire C30 et EORTC QLQ-CR29 de l'Organisation européenne pour la recherche et le traitement du cancer. Nous avons interviewé 74 patients et nos résultats indiquent que les patients agés de 55 ans et moins éprouvent un moindre niveau d'anxiété alors que le niveau de douleurs abdominales et du sentiment de gêne est élevé. Les patients atteints de métastases ont démontré lors des tests que leur état général de santé était plutôt mauvais et qu'ils souffraient de fatigue accrue, de perte de cheveux et de la perte du goût L'état émotionel était à son plus bas chez les patients au stade IV de la maladie. La fatigue, la nausée, le vomissement, la perte d'appétit, les douleurs abdominales, et la perte de goût étaient significativement plus élevés chez les patients ayant été traités par chirurgie et chimiothérapie comparativement à ceux qui n'avaient subi que la chirurgie. L'âge, les métastases et le stade avancé de la maladie combinés à divers traitements médicaux sont les facteurs ayant contribué aux scores plus bas observés sur l'échelle de qualité de vie. Les patients susceptibles de démontrer de faibles résultats devraient recevoir une attention spéciale de la part des soignants et être la cible de soins de soutien appropriés à leur état.
Who Knows, who Cares? Dementia Knowledge among Nurses, Care Workers, and Family members of People Living with Dementia
Authors: Robinson Andrew , Eccleston Claire , Annear Michael , Elliott Kate-Ellen , Andrews Sharon , Stirling Christine , Ashby Michael , Donohue Catherine , Banks Susan , Toye Christine , McInerney Fran 
Published: December 2018

The number of people with dementia is increasing rapidly worldwide. Commensurate with population ageing, the use of nursing homes in Australia (known as residential aged care facilities) for individuals with dementia is growing. As a terminal condition, dementia is best managed by instituting a palliative approach to care. A good knowledge of dementia, including its progression and management, among staff and families of people living with dementia is essential for clear decision making and the provision of appropriate care. Yet there is limited information regarding relative levels of dementia knowledge. This paper reports the results of a study that assessed dementia knowledge among these two cohorts using the Dementia Knowledge Assessment Tool; the study surveyed 279 staff members and 164 family members of residents with dementia. Dementia knowledge deficits were evident in both cohorts across a range of areas. It is critical that dementia knowledge deficits are identified and addressed in order to support evidence-based dementia care. Le nombre de personnes atteintes de démence augmente rapidement à travers le monde. Ainsi on remarque en Australie une augmentation du nombre de ces malades admis dans les institutions de soins de longue durée. La démence étant une maladie terminale il appert que l'approche palliative est la meilleure forme de soins. Cependant, il est essentiel que le personnel soignant autant que les familles aient une bonne connaissance de la maladie, de ses symptomes, de la façon de traiter les maladies, et des décisions à prendre. Or, on en sait très peu quant au niveau de connaissances de ces deux groupes de personnes sur le sujet. Cet article porte sur les résultats d'une étude qui tentait d'évaluer le niveau de connaissances de 279 membres du personnel et de 164 membres des familles à l'aide de l'Έchelle d'évaluation des connaissances sur la démence. Le peu de connaissances était évident chez les deux cohortes et ce, sur un bon nombre de points. Il est donc de la plus haute importance que l'on identifie spécifiquement ces points et qu'on améliore la qualité des soins chez les personnes démentes en se basant sur des données probantes.
Evaluation of coagulation disorders by thromboelastography in children with systemic lupus erythematosus
Authors: Li Z , Xiao J , Song H , Chen Q , Han H , Li J , Zhang L , He Y , Wei M 
Published: December 2018

Background The coagulation status of patients with systemic lupus erythematosus (SLE) is quite complicated, and there are currently no simple efficient methods for its evaluation. We explored the feasibility of thromboelastography (TEG) for this purpose. Methods Paediatric SLE patients were divided into different groups based on Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores. TEG parameters were compared between patients and healthy controls (HCs) and in patients by level of disease activity. Six patients treated with pulse methylprednisolone were also analysed before and after treatment. Results Thirty-nine children with SLE were enrolled, one of whom had bleeding and three of whom had thrombosis. The four TEG tracings of these four children were different. The TEG parameters of the patients (except the four children mentioned above) showed hypercoagulability, shortened R and K times, increased α-angle and maximum amplitude (MA), decreased LY30 and increased clot index (CI) compared with the parameters of the HCs ( P < 0.05). With respect to disease activity, patients with higher SLEDAI scores showed more obvious hypercoagulability with shortened R and K times and increased α-angle and CI ( P < 0.05). Furthermore, there was a negative correlation between both the R time and K time and SLEDAI scores ( r = –0.435, P < 0.01 and r  =  –0.572, P  < 0.001, respectively) and a positive correlation between both α-angle and CI and SLEDAI scores ( r = 0.581, P  < 0.001 and r  =  0.544, P  < 0.01, respectively). No significant difference in coagulation status was found between pre- and post-pulse therapy. Conclusions Compared with the HCs, paediatric SLE patients showed hypercoagulability caused by increased coagulation and decreased fibrinolysis. These coagulation changes were associated with disease activity. TEG could be a potential tool for evaluating the coagulation status of children with SLE.