bluuebunny/crossref_metadata_2025_split huggingface dataset:
Концепция и архитектура парсинга и хранения единой базы патентов и научных журнальных публикаций
Authors: Козина С.А. , Кулинченко И.А. , Коробкин Д.М. , Фоменков С.А. 
Published: November 2024

Существующие на текущий момент методы автоматизированного сбора данных, хотя и облегчают данный процесс, но зачастую сталкиваются с проблемами низкой надежности, эффективности и скорости. Нестабильность соединений, блокировки IP-адресов и изменения структуры сайтов приводят к потере данных и необходимости постоянного контроля процесса парсинга, что увеличивает затраты на поддержание и эксплуатацию подобных систем. В связи с этим, разработка новых подходов и инструментов для парсинга необходимой информации является весьма актуальной задачей, способной трансформировать область интеллектуального анализа данных. В статье рассмотрен процесс разработки системы парсинга информации патентных систем и сайтов физико-технических журналов с использованием современных технологий и подходов, а также представлены результаты проверки его работоспособности. Данный инструмент может быть полезен патентным ведомствам, исследователям, студентам, инженерам, ученым, работающим в рассматриваемой предметной области. Использование такой системы позволит открыть новые возможности для интеллектуального анализа данных и принятия стратегических решений в области инновационного развития, а также для глубокого анализа технологических трендов, выявления перспективных разработок и построения стратегий инновационного развития.
The currently existing methods of automated data collection, although they facilitate this process, often face problems of low reliability, efficiency and speed. Unstable connections, blocking IP addresses and changes in the structure of sites lead to data loss and the need for constant monitoring of the parsing process, which increases the cost of maintaining and operating such systems. In this regard, the development of new approaches and tools for parsing the necessary information is a very urgent task that can transform the field of data mining. The article discusses the process of developing a module for parsing information from patent systems and websites of physics and technology journals using modern technologies and approaches, and also presents the results of checking its operability. This tool can be useful for patent offices, researchers, students, engineers, and scientists working in the subject area under consideration. The use of such a module will open up new opportunities for data mining and strategic decision-making in the field of innovative development, as well as for in-depth analysis of technological trends, identification of promising developments and building innovative development strategies.
Chasing the ghost of fracking in the Vaca Muerta Formation: Induced seismicity in the Neuquén Basin, Argentina
Authors: Schultz Ryan , Tamburini-Beliveau Guillermo , Correa-Otto Sebastián , Grosso-Heredia Javier 
Published: November 2024

Earthquakes are known to be induced by a variety of anthropogenic causes, such as hydraulic fracturing. In the Neuquén Basin of Argentina, hydraulic fracturing has been used to produce hydrocarbons trapped in the shales of the Vaca Muerta Formation. Correspondingly, incidences of seismicity there have increased. We collect information on well stimulations and earthquakes to perform statistical analysis linking these two datasets together. Spatiotemporal association filters suggest that the catalogue of events is biased towards hydraulic fracturing operations. After accounting for false-positives, we estimate that ~0.5% of operations are associated with earthquakes. These associated event-operation pairs show highly correlated temporal signals (>99.99% confidence) between seismicity/injection rates. Based on this evidence, we argue that many of these earthquakes are induced. We support this argument by comparing the geological setting of the Neuquén Basin against conditions needed for fault reactivation in other susceptible/seismogenic basins. This recognition adds to the growing list of (hydraulic fracturing) induced seismicity.
Exploration of the Practical Path of Experiential Teaching Method in Piano Teaching in Comprehensive Universities
Authors: Lin Weirui 
Published: November 2024

Piano education, as an art course, occupies an important position in the art majors of comprehensive universities. With the continuous deepening of educational reform, the concept, methods, and content of piano education in comprehensive universities also need to be updated and upgraded, committed to effectively improving students’ music literacy while mastering piano knowledge and skills. The application of experiential teaching methods in piano teaching in comprehensive universities highlights the student-centered position, focuses on enhancing students’ learning experience, and promotes the high-level development of students’ comprehensive abilities. This article explores the application of experiential teaching methods in piano teaching in comprehensive universities, proposes a rational practical path, and hopes to provide a reference for relevant educators.
Research on Legal Issues in the Transformation of Research Achievements by University Faculty: A Study of the Experience of Universities in Silicon Valley, USA, and the Status Quo of Transformation of Research Achievements in Chitosan Bioactive Materials
Authors: Yan Linyin , Zhang Yu , Luo Huigen , Dai Decai , Li Yanqiang 
Published: November 2024

This paper aims to delve into the legal issues surrounding the transformation of scientific research achievements by university faculty, with a special focus on legal protection and incentive mechanisms during the transformation process. By analyzing the experience of universities in Silicon Valley, USA, in promoting research transformation, including relevant legislation, university policies, and legal safeguards, as well as strategies to maximize the willingness of both universities and faculty for transformation, this paper distills the current successful legal consensuses. Simultaneously, it examines the status quo of the transformation of research achievements in chitosan bioactive materials for medical applications in China, analyzes existing legal deficiencies and urgent issues, and proposes corresponding solutions and recommendations.
Exploration of Innovation and Entrepreneurship Education Management to Improve Students’ Employability
Authors: Xu Qiuyan , Nik Mahmood Nik Hasnaa 
Published: November 2024

With the rapid development of the economy and society and the progress of science and technology, the traditional concept of employment has been gradually broken, and more and more college students hope to realize their life value through independent entrepreneurship or employment in innovative enterprises. Based on the significance of innovation and entrepreneurship education to improve students’ employability, this paper will sort out the development status of domestic college students’ employability, analyze the current difficulties of innovation and entrepreneurship education, and try to put forward the optimization strategy of innovation and entrepreneurship education management to improve students’ employability.
FUTURE OF DIGITAL MARKETING IN INDIA – OPPORTUNITIES AND CHALLENGES
Authors: Babita R. , Rekha N 
Published: November 2024

The emergence of digital marketing has become an essential part of marketing for businesses today, leading to a gradual replacement of traditional marketing methods. Maintaining constant communication with customers before, during, and after purchase has become vital, and digital marketing enables marketers to better understand customer tastes, preferences, and choices through the use of messages, notifications, emails, and reminders. Digital marketing has become an essential part of the marketing mix for businesses in India as it offers a cost-effective and efficient way to reach out to potential customers, build brand awareness, and drive sales. With the continuous advancement of technology and the increasing usage of digital platforms, digital marketing is expected to become even more critical for businesses in the future. This paper aims to provide insight into the current state of digital marketing in India, highlighting the opportunities and challenges that businesses face as they shift their focus to digital platforms.
WAYS TO INFLUENCE THE ECONOMIC REGULATION OF LABOR PROTECTION, TAKING INTO ACCOUNT THE RISK-ORIENTED APPROACH
Authors: Bielikov A.S. , Rybalka K.A. , O.V. O.V. 
Published: November 2024

Statement of the problem. In recent years, the state of safety and working conditions at Ukrainian production facilities has continued to be difficult and dangerous, especially at construction companies (one of the ten most injury-prone industries), as evidenced by official statistics on occupational injuries, while Ukraine is living in a state of war. Huge sums of money from the state reserve funds, the Pension Fund, and the owners of enterprises themselves are spent on eliminating the consequences of industrial accidents, accidents, occupational diseases, and on helping victims and families of those killed at work. Ukraine has adopted many laws and regulations on occupational health and safety, including those that, in accordance with the Association Agreement between Ukraine, on the one hand, and the European Union, the European Atomic Energy Community and their Member States, on the other hand, have adapted Ukrainian legislation to that of the European Union, within the framework of which work is actively underway to implement a risk-based approach at the state level in the system of managing the economic safety and health of employees who are citizens of Ukraine. Business leaders (employers) understand the responsibility for the life and health of employees, the need to create proper, safe and healthy working conditions, and care about the economic development of the business, despite the high risks of today's hazards. Objective. To analyze the most effective ways of economic impact of occupational health and safety regulation, taking into account the risk-oriented approach, while maintaining the economic development of the company. Conclusion. The analysis of the most effective ways of economic impact of occupational health and safety regulation, taking into account the risk-oriented approach, shows that in the current conditions of development of enterprises in our country, it is difficult to find a universal solution that would simultaneously meet the requirements for the budget for financing occupational health and safety measures, the speed and quality of its implementation, and at the same time reduce risks in the field of occupational health and safety at workplaces. Therefore, it is difficult to predict which of these ways plays a primary role and which are acceptable, and how to ensure the efficiency of the entire system. Professional, comprehensive occupational health and safety cost planning will help to find the perfect balance between the measures taken and their economic benefits. The complexity of applying several options for economic regulation of occupational health and safety will allow the company to operate smoothly, without conflicts and have a sustainable operation, which will allow for economic growth, the organization's development strategy for the near future, and will also reduce risks in the field of occupational health and safety by taking effective preventive measures.
OBJECT-ORIENTED APPROACH IN RE-ENGINEERING: THE STMICROELECTRONICS	MANUFACTURING MODEL
Authors: Carchiolo V. , D'ambra S. , Longheu A. , Malgeri M. 
Published: November 2024

Current manufacturing systems have a very structured production model, expecially when high complexity and precision is required, as in semiconductor devices manifacturing. In addition, rapid changes in both production and market requirements may occur, hence great flexibility is also essential. These goals, together with the requirement of both adding new features as well as removing some model limitations, often impose to re-engineer periodically existing models, reducing as much as possible the time-to-market of a new product. Re-engineering means first to create an abstract representation of the system (i.e. the abstract model) through a reverse engineering process, then this model is re-designed, keeping as much as possible a high abstraction, so great expandability can be assured, as well as fully exploiting personnel know-how, so it is possible to take advantage of their experience about the model. Updating a model generally also requires to improve existing applications, both re-writing software components as well as adding new features to existing components. In this paper, the current model used inside STMicroelectronics facilities to define production flow (the sequence of operations to be performed in order to make products) is considered. First, the model and its limitations are described, then introducing an updated, enhanced, object-oriented model, with aggregational and constitutional hierarchies used to model and classify all entities and with a flexible inheritance mechanism used to speed-up and improve the definition of a production flow. It is also considered which improvements are required on the existing applications, introducing an enhanced environment capable of supporting the enhanced model while preserving at the same time both technical and economic investments through avoiding radical changes in existing environment.
Milk production of goats with different tone of the autonomic nervous system
Authors: Boychuk B. I. , Karpovskyi V. I. , Gutyj B. V. , Hryshchuk I. A. , Hryshchuk A. V. 
Published: November 2024

The active development of goat breeding is rapidly moving from small enterprises to large farms. This development is ensured by the rapid growth of demand for these products for ordinary consumers and people looking for an alternative to cow's milk. Therefore, a significant amount of effort is being made to improve the yield of dairy products from goats. This is because this farm cannot rapidly increase the number of livestock, and the demand for this product is constantly growing. Our study aimed to establish the dependence of the autonomic nervous system tone on the indicators of goat milk production. To form the experimental groups of animals, a variational pulse oscillometric study was used to calculate the following indicators: mode (Mo), mode amplitude (AMo), variation range (∆x), autonomic rhythm index (ARI), autonomic balance index (ABI), and tension index (TI). Subsequently, three experimental groups of animals were formed according to the tone of autonomic nervous regulation using the Baevsky method: sympathotonics, normotonics, and vagotonics. Statistical analysis of the results and calculation of Student's t-test to establish correlation and one-factor analysis of variance between milk production and autonomic nervous regulation tone were performed using Microsoft Excel. According to the results of the study, it was found that the highest milk production was determined in the experimental group of normotonics 1058 ± 9.76 l/year (P < 0.001), and the lowest in sympathotonics 845.5 ± 27.71 l/year (P < 0.001). Also, according to the initial data's statistical processing results, a correlation was established between milk production indicators and the tone of autonomic nervous regulation. Thus, the experimental group of normotonics had a correlation r = (-0.649) (P < 0.001), sympathotonics r = (-0.572) (P < 0.001), and vagotonics r = 0.865 (P < 0.001), which is confirmed by one - factor analysis of variance.
Distribution of chronic latent gynecological pathologies in dairy cows
Authors: Sidashova S. O. , Gutyj B. V. , Shnaider V. L. , Todoriuk V. B. 
Published: November 2024

The purpose of the research and production research in four breeding dairy farms of the industrial type was to establish the prevalence of chronic latent inflammatory processes of the reproductive organs, which lead to the loss of generative resources of dairy breeds of cattle. Analytical, structural-comparative, and statistical methods were used to perform the research tasks. The research data were obtained through a comprehensive examination of cows of the main milking herd (n = 552) and groups of culled cows due to numerous ineffective inseminations (n = 116), namely, ultrasound scanning of the tissues and uterine cavity and differential palpation of the fallopian tubes and gonads. Experimentally under in vivo conditions, it was established that compared to cows of the leading dairy herd in the culled group, the prevalence of symptoms of chronic latent endometritis was 33.93 % higher on average (P < 0.05) with significant fluctuations in different herds (from 12.06 to 67.51 %). A considerable spread of multiorgan gynecological pathology was established, namely the spread of chronic adhesive salpingitis, the symptoms of which in dairy cows were on average 39.40 % (with fluctuations of 7.18–83.65 %), which significantly increased among culled cows: +30, 77 % (in different farms from 52.17 to 90.00 %), which indicated the chronicity of long-term inflammatory processes in the endometrium and the area of the ciliated epithelium of the oviducts, which lead to chronic irreversible infertility (P < 0.01). An innovative methodological approach to improving diagnostics requires the introduction of innovations in the practical training methods of zoo-veterinary specialists and the requirements for preserving the generative and secretory functions of the reproductive organs of cows in gynecological therapy schemes.
Descrição epidemiológica dos pacientes com tuberculose pulmonar em hospital pediátrico referência do Sul do Brasil – um estudo retrospectivo de dez anos
Authors: Farias Ana Carolina , Guimarães Arthur Santos , Navarini Izabella Geórgia Formento , Carvalho Emanuela Rocha 
Published: November 2024

Este estudo visa descrever as características epidemiológicas dos pacientes com tuberculose pulmonar atendidos em hospital pediátrico referência de Santa Catarina, Brasil, 2011-2022. Tratou-se de estudo observacional e descritivo dos casos de tuberculose pulmonar com dados presentes em prontuário, em que foram analisadas variáveis epidemiológicas e demográficas, com posterior análise descritiva e percentual. Dentre os 42 pacientes incluídos no estudo, houve prevalência do sexo feminino, de cor branca, com idade entre 11 e 15 anos. O caso fonte foi identificado em 71,4% dos casos, com predomínio do contato intradomiciliar. Houve maior número de casos de tuberculose entre pré-adolescentes do sexo feminino, de cor branca com caso fonte identificável. Logo, são imprescindíveis medidas de saúde pública que visem identificar e tratar precocemente os contatos de pacientes diagnosticados com tuberculose pulmonar.
In Vitro Studies of Multifunctional Perfluorocarbon Nanoemulsions for Cancer Therapy and Imaging
Authors: Fernandes Donald A. , Fernandes Dennis D. , Gradinaru Claudiu
C. , Kolios Michael C. 
Published: November 2024

<p>Nanoparticles are attractive agents for cancer therapy because of two unique properties. First is their ability to accumulate in tumor tissue. This is due in part to their unique pharmacokinetics allowing minimal renal filtration and evading uptake by the reticuloendothelial system. Second is their high surface-to-volume ratios for carrying various sensors, therapeutics and targeting species for passive or active targeting of cancer cells.</p>
<p>Perfluorocarbon nanoemulsions are a unique class of theranostic agents which are able to solubilize a wide variety of therapeutic agents, at the same time have optical properties for tumor detection using various imaging modalities. Perfluorocarbon (PFC) nanoemulsions allow for a range of functions <em>in vivo</em> because of their biological inertness, high stability, and reduced cytotoxicity. Like many other nanoparticles, the nanoemulsions can be designed to have various targeting ligands on their surface to direct them to various biomarkers associated with cancer. It can at the same time carry a variety of extrinsic imaging agents such as chromophores for fluorescence imaging or use its intrinsic physical properties such as its density or ability to vaporize upon expansion for ultrasound and photoacoustic imaging. Its phase transition from a liquid droplet to a microbubble can be accomplished by either directly providing energy using acoustic waves or indirectly through the use of optical absorbers (i.e. gold nanoparticles) which can transfer energy as heat to PFC nanodroplets. This work will study the effect of perfluorocarbon nanoemulsions in breast cancer cell lines (i.e. MCF-7, MDA-MB 231) and will quantify nanodroplet and nanoparticle uptake and co-diffusion using various fluorescence techniques (i.e. dual color fluorescence correlation spectroscopy and total internal reflection fluorescence microscopy) to determine their efficacy as theranostic agents.</p>
Phase Change Nanoemulsions for Cancer Therapy and Imaging
Authors: Fernandes Donald
A. , Fernandes Dennis D. , Wang Yan J. , Li Yuchong , Gradinaru Claudiu
C. , Rousseau Dérick , Kolios Michael C. 
Published: November 2024

<p>Much of the biological therapeutics currently available struggle to function as effective drug delivery vehicles due in part to their poor stability, solubility, and permeability across barriers such as the tight junctions between endothelial cells in tumor vasculature. Given this understanding, there is currently a significant interest in designing nanocarriers (< 100 nm in diameter) which are able to increase the bioavailability of drugs. In particular, much attention has been focused on nanoemulsions whose liposome-like structure protects drugs against physico-chemical and enzymatic degradation and charged surface favors drug adsorption. One novel class of nanoemulsions called perfluorocarbon (PFC) emulsions are of particular interest because they can be used both for delivering drugs and imaging tumors. In this work we show that nanoemulsions with a PFC core and Zonyl FSP surfactant shell can be produced using an oil-in-water technique via sonication. This technique is successful in producing PFC emulsions that are on average 50 nm in diameter with long-term stability at physiological conditions, as determined by Electron Microscopy, Fluorescence Correlation Spectroscopy and Dynamic Light Scattering. Using laser excitation, these nanoemulsions can vaporize into microbubbles in the presence of silica coated gold nanoparticles for efficient drug release and imaging using high contrast imaging modalities such as photoacoustic microscopy. Taken together, the size and stability of these PFC nanodroplets make them cost effective drug delivery vehicles suitable for efficient internalization by cancer cell lines.<br>
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