bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete Remission Following Pembrolizumab in a Woman with Mismatch Repair-Deficient Endometrial Cancer and a Germline BRCA1 Mutation
Authors: Dizon Don S. , Dias-Santagata Dora , Bregar Amy , Sullivan Laura , Filipi Jennifer , DiTavi Elizabeth , Miller Lucy , Ellisen Leif , Birrer Michael , DelCarmen Marcela 
Published: February 2018

Abstract

Endometrial cancer is the most common gynecologic malignancy in the U.S. and, although the majority of cases present at an early stage and can be treated with curative intent, those who present with advanced disease, or develop metastatic or recurrent disease, have a poorer prognosis. A subset of endometrial cancers exhibit mismatch repair (MMR) deficiency. It is now recognized that MMR-deficient cancers are particularly susceptible to programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors, and in a landmark judgement in 2017, the U.S. Food and Drug Administration granted accelerated approval to pembrolizumab for these tumors, the first tumor-agnostic approval of a drug. However, less is known about the sensitivity to PD-1 blockade among patients with known mutations in double-strand break DNA repair pathways involving homologous recombination, such as those in BRCA1 or BRCA2. Here we report a case of a patient with an aggressive somatic MMR-deficient endometrial cancer and a germline BRCA1 who experienced a rapid complete remission to pembrolizumab.

Key Points
Endometrial cancers, and in particular endometrioid carcinomas, should undergo immunohistochemical testing for mismatch repair proteins. Uterine cancers with documented mismatch repair deficiency are candidates for treatment with programmed cell death protein 1 inhibition. Genomic testing of recurrent, advanced, or metastatic tumors may be useful to determine whether patients are candidates for precision therapies.
Relationship between obesity and platelet indices in children
Authors: ÖZSU Elif , YAZICIOGLU Bahadır 
Published: February 2018

Purpose: The aim of this study was to assess platelet count, MPV and PDW as metabolic indicator in obese children with or without insuline resistances.Materials and Methods: Two hundered sixtyseven obese patients (160 female) and 50 (25 female) controls were enrolled. Anthropometric measurements, triglyceride, total cholesterol, high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), uric acid, hemoglobin, platelet count, MPV, PDW and insulin resistance by using homeostasis model of assessment of insulin resistance (HOMA-IR) and oral glucose tolerance test were investigated. Results: Uric acid level were significantly higher in the obese group while there was no statistically significantly differences in platelet indices between in the two groups. Platelet counts, MPV and PDW levels were not significantly different between in three groups. However MPV inversely correlated with HOMA-IR, platelet counts, ALT and LDL levels and positively correlated with PDW. Conclusion: The relationship between platelets, MPV, PDW has previously been demonstrated. However platelet indices may not to be related to degree of obesity as currently thought. Uric acid may be a more useful marker for selected patients with insulin resistance.
Critical thinking in clinical nursing: a content analysis
Authors: Bahmanpour Kaveh , Navipour Hassan , Ahmadi Fazlollah , KAZEMNEJAD Anoshiravan 
Published: February 2018

Purpose: Delivery of safe, effective and efficient care are important goals of qualified nursing care which can be met by acquiring critical thinking skills. In nursing critical thinking is a general concept and there are many uncertainty about its definition. In this paper, a specific definition of critical thinking is offered which has a direct relationship with clinical nursing.Methods: In this qualitative content analysis, data were gathered from 18 nurses who had direct involvement with subjects. Semi structured interviews in Tehran, Karaj and Sanandaj hospitals, were conducted .The data were analyzed through inductive content analysis.Results: The extracted attributes of critical thinking were using nursing process in facing with clinical situations, being criterion-based in making clinical decisions, emphasizing on holistic performances, personal critical thinking dispositions and using emotional intelligence in facing with clinical situations Conclusions: The emerged categories were resulted in developing an operative definition about the critical thinking in the context of clinical nursing. This definition can help practitioners to develop a framework and guidelines for effective performance in practice. This framework usually guarantees competency in nursing.
Peran Kepemimpinan Kepala Madrasah dalam Meningkatkan Mutu Pendidikan Islam
Authors: Tin Marya 
Published: February 2018

Artikel ini akan menjelaskan secara singkat peran kepemimpinan kepala madrasah dalam meningkatkan mutu pendidikan. Seorang pemimpin sekolah memiliki peran strategis untuk mewujudkan kualitas sekolah pendidikan. Lembaga ini membutuhkan pemimpin yang memiliki kemampuan dalam memimpin. Penggerak utama adalah tokoh dan inspirasi dalam merancang dan mengerjakan kegiatan di sekolah. Pemimpin bukan hanya seorang Manajer, dia juga harus menjadi pembangun mental, moral, semangat, dan kolektivitas untuk jajaran bawahannya dan tidak hanya menggunakan aturan tertulis, tetapi juga sikap perilakunya, figur, dan contoh dalam melakukan agenda transformasi kepemimpinan yang lebih baik. Pemimpin tidak harus dianggap sebagai objek eksploitasi, dengan demikian bawahannya harus dianggap sebagai teman dan mitra kerja. Jadi tidak ada kesewenang-wenangan dan ketidakadilan. Karena tanpa bawahan pemimpin kurang berarti. This article will briefly explain the role of the leadership of the head of school in improving education quality. A school leader has a strategic role to realize the school's quality of education. The institution needs a leader who has skills in leading. The principal mover is a figure and inspiration in designing and working on activities at the school. The leader is not just a Manager, he or she must also be a builder of mental, moral, spirit, and collectivity to his subordinates. He must not only use the written rules, but also the attitude of his behavior, image, and example in making a better leadership transformation agenda. The leader should not be regarded as an object of his exploits, thus his subordinates should be considered as friends and working partners. So there's no arbitrariness besides injustice. Leaders’ role is meaningless without his subordinate. Kata kunci: kepemimpinan, kualitas pendidikan, sekolah islam, madrasah
Implementasi Pendidikan Karakter dalam Mata Pelajaran ISMUBA
Authors: No Mulyo 
Published: February 2018

Penelitian ini bertujuan untuk mengungkapkan bagaimana implementasi pendidikan karakter ISMUBA ((Al - Islam, Muhammadiyah dan bahasa Arab) di sekolah-sekolah Muhammadiyah Salatiga pada tahun akademik 2012/2013. Dalam studi ini, peneliti menggunakan metode kualitatif dengan pendekatan beragam yaitu filosofis, fenomenologi, dan psikologi. Metode konten analisis digunakan sebagai metode analisis. Melalui metode, pendekatan dan analisis tersebut, ditemukan bahwa hal terpenting adalah implementasi pendidikan karakter di sekolah-sekolah Muhammadiyah, termasuk sekolah-sekolah Muhammadiyah Salatiga, telah ada sejak lama, sebelum hal tersebut diutarakan oleh pemerintah Indonesia. Pendidikan karakter di sekolah-sekolah Muhammadiyah diimplementasikan dalam karakter-karakter khusus mata pelajaran dengan nama ISMUBA (Al - Islam, Muhammadiyah dan bahasa Arab). Ini adalah mata pelajaran yang penting yang bertujuan dalam pembentukan karakters iswa, ini adalah karakter keislaman dalam nuansa Muhammadiyah. Saat ISMUBA sukses diaplikasikan, hal ini akan membentuk siswa yang Islami dengan semangat Muhammadiyah. This study is aimed to reveal about how the implementation of the character education of ISMUBA (Al - Islam, Muhammadiyah and Arabic) in Salatiga Muhammadiyah schools in the academic year of 2012/2013. In this study, the researcher used qualitative methods with multiple approaches namely philosophical, phenomenological, and psychological approaches. The content analysis method is utilized as its analytical method. Through those methods, approaches and analysis, it was found that the most important thing is the implementation of character education in Muhammadiyah schools, including Salatiga Muhammadiyah schools, was existed since long time ago, before it was proclaimed by the Indonesia’s government. Character education in Muhammadiyah schools was implemented on particular characteristics of subjects, namely ISMUBA (Al - Islam, Muhammadiyah and Arabic). This is a very significant subject which is essentially oriented in the students’ character building, it is religious character (Islamic) in Muhammadiyah nuance. When ISMUBA is successful applied, it will form Islamic students with Muhammadiyah spirit. Keywords: ISMUBA, Muhammadiyah, pendidikan karakter
PEMBELAJARAN PENDIDIKAN AGAMA ISLAM (PAI) BERBASIS MULTIKULTURAL
Authors: Novayani Irma 
Published: February 2018

Pendidikan multikultural adalah sebuah sistem pendidikan yang berupaya untuk meredam kesenjangan sosial, kelas sosial, kecemburuan sosial dengan mengenalkan dan mensosialisasikan salah satu orientasinya yakni kebersamaan. Oleh karena itu dalam lembaga pendidikan Islam perlu menerapkan sistem pengajaran yang berorientasi pada penanaman kesadaran pluralisme dalam kehidupan. Adapun beberapa program pendidikan yang sangat strategis dalam menumbuhkan kesadaran pluralisme adalah: pendidikan sekolah harus membekali para mahasiswa atau peserta didik dengan kerangka (frame work) yang memungkinkannya menyusun dan memahami pengetahuan yang diperoleh dari lingkunganya.Gagasan mengenai multikultural bukanlah sesuatu yang sulit, karena di dalam agama Islam mengajarakan tentang saling menghormati dan mengakui kebaradaan orang lain. perbedaan warna kulit, bahasa, dan budaya harus diterima sebagai sesuatu yang positif dan merupakan tanda-tanda dari kebesaran Allah SWT. Untuk itu sikap yang diperlukan bagi seorang muslim dalam merespon kemajemukan dan perbedaan adalah dengan memandangnya secara positif.
A Qualitative Comparative Analysis of Combined State Health Policies Related to Human Papillomavirus Vaccine Uptake in the United States
Authors: Roberts Megan C. , Murphy Taylor , Moss Jennifer L. , Wheldon Christopher W. , Psek Wayne 
Published: February 2018

Objectives. To examine how combinations of state policies, rather than single policies, are related to uptake of human papillomavirus (HPV) vaccine.Methods. Using publicly available records and the literature, we characterized policies for each US state and Washington, DC, in 2015 (n = 51), including (1) Medicaid expansion, (2) policies permitting HPV vaccination in pharmacies, (3) school-entry requirements, (4) classroom sex education mandates, and (5) parental education mandates. Using qualitative comparative analysis, we identified which existing combinations of these policies were necessary and sufficient for high HPV vaccine initiation among adolescents, with National Immunization Survey-Teen data.Results. No single policy was necessary or sufficient for high HPV vaccine uptake; however, 1 set of policies had consistently high HPV vaccine uptake: adoption of all policies except parental education mandates (girls: consistency = 1.00, coverage = 0.07; boys: consistency = 0.99, coverage = 0.08).Conclusions. We identified a set of polices related to high HPV vaccine uptake. Future studies should examine how these policies and others, individually and in combination, are associated with HPV vaccine uptake.Public Health Implications. This study provides insight into what sets of policies are consistently related to high HPV vaccine uptake.
Disparities in Distribution of Particulate Matter Emission Sources by Race and Poverty Status
Authors: Mikati Ihab , Benson Adam F. , Luben Thomas J. , Sacks Jason D. , Richmond-Bryant Jennifer 
Published: February 2018

Objectives. To quantify nationwide disparities in the location of particulate matter (PM)-emitting facilities by the characteristics of the surrounding residential population and to illustrate various spatial scales at which to consider such disparities. Methods. We assigned facilities emitting PM in the 2011 National Emissions Inventory to nearby block groups across the 2009 to 2013 American Community Survey population. We calculated the burden from these emissions for racial/ethnic groups and by poverty status. We quantified disparities nationally and for each state and county in the country. Results. For PM of 2.5 micrometers in diameter or less, those in poverty had 1.35 times higher burden than did the overall population, and non-Whites had 1.28 times higher burden. Blacks, specifically, had 1.54 times higher burden than did the overall population. These patterns were relatively unaffected by sensitivity analyses, and disparities held not only nationally but within most states and counties as well. Conclusions. Disparities in burden from PM-emitting facilities exist at multiple geographic scales. Disparities for Blacks are more pronounced than are disparities on the basis of poverty status. Strictly socioeconomic considerations may be insufficient to reduce PM burdens equitably across populations.
FRACTURE MECHANICS SIMPLE CALCULATIONS TO EXPLAIN SMALL REDUCTION OF THE REAL CONTACT AREA UNDER SHEAR
Authors: Ciavarella Michele 
Published: February 2018

In a very recent paper, Sahli and coauthors [12] (R. Sahli et al., 2018, “Evolution of real contact area under shear”, PNAS, 115(3), pp. 471-476) studied the contact area evolution for macroscopic smooth spheres under shear load in presence of adhesion. It was found that contact area AA reduces quadratically with respect to shear load T, i.e. A=A0-alphaAT2, where A0 is the contact area with no shearing, and alphaA is the "area reduction parameter" found to be approximately proportional to A0-3/2 across 4 orders of magnitude of A0. In this note we focus on the smooth sphere/plane contact because we believe that the case of a rough contact requires separate investigations, and we use a known model of fracture mechanics, which contains a fitting parameter b which governs the interplay between fractures modes, in order to find very good agreement between the data and the analytical predictions, developing relatively simple equations. The interaction with modes is limited.
Makerspace in Education - Disruptive Technology or Just Another Passing Fad?
Authors: Gilbert Jane 
Published: February 2018

Makerspaces are now common in schools. This idea, which originated outside education, is being advocated as a way to improve student engagement in learning and/or to foster creativity and/or innovation. It is also linked with “future-focused” education and is seen by some as a potentially disruptive force for good in education. This paper evaluates these claims. It looks at the origins of the makerspace concept and at how and why it was taken up by educationists. Via an exploration of the ideas about knowledge, learning and education assumed by its proponents, it assesses makerspace’s general educative potential and its likely contribution to the development of future-focused education. It concludes that the makerspace idea could be usefully disruptive in terms of education’s future development, but that this is unlikely without system-wide cognitive change.
The Experimenting Society
Authors: Davis Melinda F. 
Published: February 2018

Donald Campbell wrote eloquently about the need to evaluate social reforms and lamented the lack of solid evaluation research to guide these reforms (1973). He suggested that social reforms be thought of as experiments, and society’s focus be on important problems rather than single solutions to these problems. Campbell’s vision of an experimenting society, in which reforms are evaluated and new approaches to social problems are developed based on evaluation outcomes has yet to be realized. DOI:10.2458/azu_jmmss_v5i2_davis
Elevated serum uric acid affects myocardial reperfusion and infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
Authors: Mandurino-Mirizzi Alessandro , Crimi Gabriele , Raineri Claudia , Pica Silvia , Ruffinazzi Marta , Gianni Umberto , Repetto Alessandra , Ferlini Marco , Marinoni Barbara , Leonardi Sergio , De Servi Stefano , Oltrona Visconti Luigi , De Ferrari Gaetano M. , Ferrario Maurizio 
Published: February 2018

Aims
Elevated serum uric acid (eSUA) was associated with unfavorable outcome in patients with ST-segment elevation myocardial infarction (STEMI). However, the effect of eSUA on myocardial reperfusion injury and infarct size has been poorly investigated. Our aim was to correlate eSUA with infarct size, infarct size shrinkage, myocardial reperfusion grade and long-term mortality in STEMI patients undergoing primary percutaneous coronary intervention.

Methods
We performed a post-hoc patients-level analysis of two randomized controlled trials, testing strategies for myocardial ischemia/reperfusion injury protection. Each patient underwent acute (3–5 days) and follow-up (4–6 months) cardiac magnetic resonance. Infarct size and infarct size shrinkage were outcomes of interest. We assessed T2-weighted edema, myocardial blush grade (MBG), corrected Thrombolysis in myocardial infarction Frame Count, ST-segment resolution and long-term all-cause mortality.

Results
A total of 101 (86.1% anterior) STEMI patients were included; eSUA was found in 16 (15.8%) patients. Infarct size was larger in eSUA compared with non-eSUA patients (42.3 ± 22 vs. 29.1 ± 15 ml, P = 0.008). After adjusting for covariates, infarct size was 10.3 ml (95% confidence interval 1.2–19.3 ml, P = 0.001) larger in eSUA. Among patients with anterior myocardial infarction the difference in delayed enhancement between groups was maintained (respectively, 42.3 ± 22.4 vs. 29.9 ± 15.4 ml, P = 0.015). Infarct size shrinkage was similar between the groups. Compared with non-eSUA, eSUA patients had larger T2-weighted edema (53.8 vs. 41.2 ml, P = 0.031) and less favorable MBG (MBG < 2: 44.4 vs. 13.6%, P = 0.045). Corrected Thrombolysis in myocardial infarction Frame Count and ST-segment resolution did not significantly differ between the groups. At a median follow-up of 7.3 years, all-cause mortality was higher in the eSUA group (18.8 vs. 2.4%, P = 0.028).

Conclusion
eSUA may affect myocardial reperfusion in patients with STEMI undergoing percutaneous coronary intervention and is associated with larger infarct size and higher long-term mortality.
Kode Etik Jurnalisme di Indonesia dan Inggris Raya
Authors: Sari Astrid Puspita 
Published: February 2018

AbstrakEtika bukan hanya soal kode etik atau aturan yang harus diikuti. Hal ini lebih terkait dengan prinsip-prinsip tentang yang benar dan yang salah dari perilaku manusia yang berlaku obyektif dan tidak memihak. Praktek jurnalisme sebagai suatu profesi menimbulkan permasalahan etika. Tulisan ini bermaksud membandingkan kode etik praktek jurnalistik yang dilakukan wartawan Inggris Raya dan Indonesia serta membahas beberapa contoh malpraktek etika kerja jurnalistik. Walaupun di kedua negara tersebut menjunjung kebebasan pers dan kebebasan informasi. Di Inggris sendiri media lebih dibatasi oleh hukum dan kode etik tertentu secara spesifik. Sedangkan di Indonesia, media tetap dibatasi oleh hukum tapi tidak secara spesifik meskipun kode etik jurnalistik juga digunakan sebagai salah satu aturan yang ada. Tulisan ini menyajikan perbedaan dalam hal etika jurnalistik yang digunakan oleh wartawan dari kedua negara tersebut. AbstractJournalism Code of Ethics in Indonesia and United Kingdom. Ethics is not just a matter of codes of conducts or rules to be followed. It is more related to principles concerning the rights and wrongs of human conduct applied objectively and impartially. The practice of journalism as a profession raises many ethical issues. This essay compares the journalist’s practice code of ethics between United Kingdom and Indonesia and also discusses some examples of malpractices ethics of journalistic work. In Britain, the media are more restricted by specific law and codes of conducts. Whereas, in Indonesia, the media are restricted by law but not in specific areas even though also using the journalistic codes of conducts as one of the rules. However, both countries they have the idea of free press and freedom of information. This essay presents those differences in terms of ethics that is being used by the journalist from both countries.
Dinamika Pengembangan Ilmu Falak di Pesantren
Authors: Kholilah Fitri 
Published: February 2018

Sejak awal perkembangannya di Indonesia, ilmu falak tidak bisa dipisahkan dari dunia pesantren, para Ulama terdahulu membawa ilmu falak setelah mereka belajar kepada guru-guru mereka baik di dalam maupun di luar negeri lalu mengajarkan kepada santri-santrinya melalui pondok pesantren. Berdasarkan observasi yang dilakukan oleh penulis ternyata masih ada beberapa pondok pesantren yang melakukan pengembangan ilmu falak di antaranya Pondok Pesantren Al-Hikmah 2 Brebes Jawa Tengah, Pondok Pesantren Salafiyah Kajen Pati Jawa Tengah, Pondok Pesantren Tremas Pacitan Jawa Timur, Pondok Pesantren Lirboyo Kediri dan Pondok Al-Falah Ploso Kediri Jawa Timur.
Jenis penelitian yang digunakan yaitu jenis penelitian kualitatif. dengan pendekatan lapangan (field Reseacrh) dengan Metode pengumpulan data observasi, dokumentasi dan wawancara. Setelah data terkumpul, penulis melakukan analisis menggunakan metode analisis deskriptif.
Hasil penelitian ini menunjukkan bahwa ke-lima pondok pesantren di atas merupakan lembaga pendidikan yang istiqomah dan cukup serius dalam melakukan pengembangan terhadap ilmu falak, terbukti dengan memasukkan ilmu falak ke dalam kurikulum pembelajaran. Secara umum model pengembangan ilmu falak yang dikembangkan oleh pondok-pondok pesantren diatas adalah dengan memadukan dua teori perhitungan, yaitu teori klasik dan konemporer.
Foreign investment in Indonesia The Legal Aspects under the New Indonesian Investment Law
Authors: Bunawan Petra 
Published: February 2018

Indonesia plays an important role in the ASEAN region as well as in the global community, therefore investment policy become one of the major concern to government. To meet and accomodate the business enviroment both domestic and overseas that need capital investment, thus to develop the economic growth and build a suistainable economic stability in the region as well as for the people of Indonesia, it is neccessary to stipulate the inevestment law that provide all the need . Therefore the government has replaced the old law with the new Investment Law, the law No 25 of 2007. The Law provides the basic principle of legal certainty, non discrimination and same treatment for investors both domestic and overseas. The principles of opennes, accountability, togetherness and the concept of repatriation support the friendly investment atmosphere in Indonesia. As well as the supportive fasilities and easy procedure for investors to invest and build business in Indonesia. One of important issues regarding to Investment law is to increase the direct investment, instead of indirect investment that its contribution has a difference impact to the real sectors and economic growth.The question is the law and supportive law accomodatively provides the need of investment enviroment, knowing the economic growth has been influenced by the era of globalization and in fact Indonesia has signed and ratified international agreement as well. This writing will give a slighty persfective according to Indonesian Investment law and other supportive law, both national and international . Keywords: Law, Investment, Government Regulation, Principles, international law