bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mini review of paragangliomas with presentation of two cases
Authors: Kader E. 
Published: August 2019

Paragangliomas are rare tumours of the paraganglion system, which may, in approximately 80% of cases, be hormonally active with potentially lethal consequences. In this mini review, the classification, pathology, pathophysiology and clinical management are described. An attempt is also made to evaluate the relative advantages and disadvantages of the most commonly used diagnostic imaging modalities, viz. Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and radionuclide scintigraphy. Paragangliomas are divided into four anatomical classes:1. Paragangliomas arising from the adrenal medulla2. Aortico-sympathetic paragangliomas3. Parasympathetic and visceroautonomic paragangliomas4. Paragangliomas not otherwise specified. They occur sporadically or in families, and have recognised associations with other diseases. The majority are benign. Ninety percent of tumours are adrenal and 1O% are extra-adrenal. Patients commonly present with hypertension or paroxysmal crises and the laboratory diagnosis hinges on the demonstration of elevated catecholamine levels. Initial management involves stabilisation with alpha-blockade followed by preoperative tumour localisation.MRI has similar accuracy to CT in diagnosis of adrenal tumours. MRI surpasses metaiodobenzylguanidine (MIBG) scanning in detecting adrenal disease and non-functional paragangliomas. MIBG has greater sensitivity and specificity than MRI in the detection of extra-adrenal tumours, although both are superior to CT. MRI is currently the investigation of choice, with MIBG being used in cases of disease recurrence, metastases or equivocal MRI. Surgical cure is possible in up to 85% of cases. The recurrence rate is between 5 and 10%, with a 5 year survival rate of 80 to 95%.
Development of two-stage multi-anvil apparatus for low-temperature measurements
Authors: Ishigaki K. , Gouchi J. , Nagasaki S. , Cheng J. G. , Uwatoko Y. 
Published: August 2019

The two-stage 6-8 multi-anvil (MA8) apparatus is an important large-volume, high-pressure technique that has been widely used in the high pressure mineralogy and material synthesis, mainly at room temperature or above. Recently, we have successfully developed a two-stage MA8 apparatus for low-temperature physical property measurements. The first-stage anvils at top and bottom sides are fabricated as a single piece in order to reduce the total size of the cylindrical module, which is put in a top-loading high pressure cryostat and compressed by a 1000 ton hydraulic press. A castable, split octahedral gasket with integrated fin was specifically designed in order to introduce the electrical leads from the inside sample container filled with a liquid pressure transmitting medium. By using tungsten carbide (WC) second-stage cubes with a truncated edge length of 3 mm and an octahedral gasket with an edge length of 6 mm, we have successfully generated pressure over 20 GPa at room temperature. Since the high pressure limit can be pushed to nearly 100 GPa by using the sintered diamond second-stage cubes, our MA8 apparatus has a great potential to expand the current pressure capacity for precise low-temperature measurements with a large sample volume.
Edited by: A. Goñi, A. Cantarero, J. S. Reparaz
A pesquisa Científica que Critica a Publicidade Estereotipada: uma busca histórica nas publicações em marketing e publicidade (1971-2018)
Authors: Bevilacqua Solon , Medeiros Cintia Rodrigues de Oliveira 
Published: August 2019

Este artigo fornece uma revisão abrangente e sistemática da literatura crítica da publicidade comercial. Foi realizado um estudo bibliométrico, a fim de mapear a temática pensamento crítico na grande área da publicidade comercial e marketing`. As bases consultadas - ‘Periódicos Capes’, `Google Scholar’, ‘Scopus’ e ‘Direct Science’- indicaram que há disseminação do pensamento crítico no campo da publicidade comercial, janela entre os anos 1971 e 2018. Constatou-se que há publicações críticas em periódicos prestigiados nas áreas de marketing e publicidade; há presença expressiva de pesquisadores realizando estudos relacionados a este campo de estudo e o tema se apresenta oportuno (o interesse é crescente entre os pesquisadores). Conclui-se sugerindo uma agenda de pesquisas futuras que investiguem outras bases de dados e pensamento em outras áreas da comunicação.
High-resolution vertical total electron content maps based on multi-scale B-spline representations
Authors: Goss Andreas , Schmidt Michael , Erdogan Eren , Görres Barbara , Seitz Florian 
Published: August 2019

Abstract. For more than 2 decades the IGS (International GNSS Service) ionosphere associated analysis centers (IAACs) have provided global maps of the vertical total electron content (VTEC). In general, the representation of a 2-D or 3-D function can be performed by means of a series expansion or by using a discretization technique. While in the latter case, pixels or voxels are usually chosen
for a spherical function such as VTEC, for a series expansion spherical harmonics (SH) are primarily used as basis functions. The selection of the best suited approach for ionosphere modeling means a trade-off between the distribution of available data and their possibility of representing ionospheric variations with high resolution and high accuracy. Most of the IAACs generate global ionosphere maps (GIMs) based on SH expansions up to the spectral degree n=15 and provide them with a spatial resolution of 2.5∘×5∘ with respect to the latitudinal and longitudinal directions, respectively, and a temporal sampling interval of 2 h. In recent years, it has frequently been claimed that the spatial resolution of the VTEC GIMs has to be increased to a spatial resolution of 1∘×1∘ and to a temporal sampling interval of about 15 min. Enhancing the grid resolution means an interpolation of VTEC values for intermediate points but with no further information about variations in the signal. n=15 in the SH case, for instance, corresponds to a spatial sampling of 12∘×12∘. Consequently, increasing the grid resolution concurrently requires an extension of the spectral content, i.e., to choose a higher SH degree value than 15. Unlike most of the IAACs, the VTEC modeling approach at Deutsches Geodätisches Forschungsinstitut der Technischen Universität München (DGFI-TUM) is based on localizing basis functions, namely tensor products of polynomial and trigonometric B-splines. In this way, not only can data gaps be handled appropriately and sparse normal equation systems be established for the parameter estimation procedure, a multi-scale representation (MSR) can also be set up to determine GIMs of different spectral content directly, by applying the so-called pyramid algorithm, and to perform highly effective data compression techniques. The estimation of the MSR model parameters is finally performed by a Kalman filter driven by near real-time (NRT) GNSS data. Within this paper, we realize the MSR and create multi-scale products based on B-spline scaling, wavelet coefficients and VTEC grid values. We compare these products with different final and rapid products from the IAACs, e.g., the SH model from CODE (Berne) and the voxel solution from UPC (Barcelona). In contrast to the abovementioned products, DGFI-TUM's products are based solely on NRT GNSS observations and ultra-rapid orbits. Nevertheless, we can conclude that the DGFI-TUM's high-resolution product (“othg”) outperforms all products used within the selected time span of investigation, namely September 2017.
‘Embu’ <i>Wh</i>- questions in Cypriot Greek: A comparative study
Authors: Kanikli Antri , Tsoulas George 
Published: August 2019

This paper proposes a novel syntactic analysis for embu Wh- questions in Cypriot Greek; a Wh- question variant which is similar to the est-ce que interrogatives in French and the é que interrogatives in European Portuguese. The paper examines properties of the embu questions which have not been addressed in the literature and investigates the asymmetries these interrogatives are assumed to display. Adopting a Split-CP analysis, we argue that embu is a Wh- head; an analysis which accounts for the examined syntactic and semantic properties of these questions. Given the similarities of these structures to the é que interrogatives in European Portuguese and the est-ce que interrogatives in French, the paper reviews the disagreements in the literature with regards to the analysis of these Wh- questions and explores whether the analysis that is proposed for embu questions could accommodate these data as well.
Out-of-plane seismic performance of plasterboard partition walls via quasi-static tests
Authors: Petrone Crescenzo , Magliulo Gennaro , Lopez Pauline , Manfredi Gaetano 
Published: August 2019

Internal partitions, as many nonstructural components, should be subjected to a careful and rational seismic design, as is done for structural elements. A quasi-static test campaign aimed at the evaluation of the out-of-plane seismic performance of Siniat plasterboard internal partitions with steel studs was conducted according to FEMA 461 testing protocol. Four tall, i.e. 5 m high, specimens were selected from the range of internal partitions developed in Europe by Siniat, a leading supplier of plasterboard components in Europe.
Under the specified testing protocol, a significant nonlinear pinched behaviour of the tested specimen was observed. The pinched behaviour was caused by the damage in the screwed connections, whose cyclic behaviour was strongly degrading. Both stiffness and strength of the specimens are significantly influenced by the board typology and the amount of screwed connections. Finally, it was concluded that Eurocodes significantly underestimate the resisting bending moment of the tested specimens.
Lost in Transportation: Calcium Oxalate Crystals in Kidney Biopsy Specimens Fixed in Michel Medium May Disappear
Authors: Cassol Clarissa A. , Braga Juarez R. , Hartage Ramon , Satoskar Anjali A. , Nadasdy Tibor , Brodsky Sergey V. 
Published: August 2019

Context.—
Calcium oxalate (CaOx) deposits in a kidney biopsy specimen can be seen in acute or chronic kidney injury and in oxalate nephropathy. Although no established cutoff criteria to diagnose oxalate nephropathy versus incidental CaOx deposition in the kidney exist, these conditions require different treatment. We noticed a significant decrease in the number of CaOx deposits in the kidney biopsy cores that were fixed in Michel transport medium (MTM) as compared to their counterparts fixed in formalin.

Objective.—
To investigate the impact of different fixatives on the number of CaOx deposits in kidney biopsy specimens.

Design.—
Retrospective search for kidney biopsies with diagnosis of CaOx deposition was performed in our Renal Pathology Database between January 1, 2015 and October 15, 2018.

Results.—
Seventy-six biopsies with an increased number of CaOx deposits were identified. CaOx deposits were counted on slides from the frozen tissue (MTM fixed or fresh frozen) and from the formalin-fixed cores. The density of CaOx deposits was significantly higher in formalin-fixed cores (13.6 ± 10.0/cm) than in MTM-fixed cores (3.2 ± 5.1/cm; P &lt; .001). CaOx density in the kidney biopsy specimens decreased progressively with increased fixation time in MTM. No significant differences in the CaOx density between formalin-fixed and fresh frozen tissue were observed.

Conclusions.—
Our data demonstrate that fixation in MTM may result in a significant reduction in the number of CaOx deposits in a kidney biopsy specimen. This may make the diagnosis difficult, especially in small biopsy specimens with limited tissue in the formalin-fixed paraffin block.
Osteopathic Manipulative Therapy in Patients With Chronic Tension-Type Headache: A Pilot Study
Authors: Deodato Manuela , Guolo Franco , Monticco Antonella , Fornari Mauro , Manganotti Paolo , Granato Antonio 
Published: August 2019

Abstract

Context
Nonpharmacologic treatment, such as osteopathic manipulative therapy (OMTh; manipulative care provided by foreign-trained osteopaths) may be a beneficial complementary treatment for tension-type headache. However, to the authors’ knowledge, the benefit of OMTh in the management of tension-type headache has not been explored, especially chronic tension-type headache (CTTH).

Objective
To investigate the effectiveness of OMTh compared with traditional treatment in reducing pain intensity, frequency, and duration of CTTH, and to evaluate the objective postural measurement of the forward head posture (FHP) as an integral parameter in the assessment of the effects of OMTh and traditional management of CTTH.

Methods
Patients with CTTH were registered at the Headache Centre of Trieste in Italy. At the time of the study, none of the patients had been taking any headache prophylaxis in the past 3 months. A 3-month baseline period was recorded by all patients with an ad hoc diary. Patients were randomly placed in the test or control group using a simple randomization program in Excel (Microsoft). Patients in the OMTh group underwent a 3-month period of OMTh, and patients in the control group were treated with amitriptyline. Pain intensity, frequency, and duration of headaches, as well as FHP were analyzed.

Results
The study enrolled 10 patients (mean [SD] age, 42.6 [15.2] years) in the OMTh group and 10 patients (51.4 [17.3] years) in the control group. The final assessment of OMTh patients showed statistically significant changes in all headache parameters: pain intensity decreased from a mean (SD) score of 4.9 (1.4) to 3.1 (1.1) (P=.002); frequency decreased from 19.8 (6) to 8.3 (6.2) days per month (P=.002); and the duration of headaches decreased from 10 (4.2) to 6 (3) hours (P=.01). Significant improvement of all parameters was found in the control group as well: pain intensity decreased from a mean (SD) score of 5.9 (0.7) to 4.2 (1.75) (P=.03); frequency decreased from 23.4 (7.2) to 7.4 (8.7) days per month (P=.003); and duration decreased from 7.8 (2.9) to 3.6 (2.1) hours (P=.002). Forward head posture significantly improved in OMTh patients (P=.003).

Conclusions
Our data suggested that OMTh may be an effective treatment to improve headaches in patients with CTTH. Our results also suggest that OMTh may reduce FHP.
Citation.js: a format-independent, modular bibliography tool for the browser and command line
Authors: Willighagen Lars G. 
Published: August 2019

BackgroundGiven the vast number of standards and formats for bibliographical data, any program working with bibliographies and citations has to be able to interpret such data. This paper describes the development of Citation.js (https://citation.js.org/), a tool to parse and format according to those standards. The program follows modern guidelines for software in general and JavaScript in specific, such as version control, source code analysis, integration testing and semantic versioning.ResultsThe result is an extensible tool that has already seen adaption in a variety of sources and use cases: as part of a server-side page generator of a publishing platform, as part of a local extensible document generator, and as part of an in-browser converter of extracted references. Use cases range from transforming a list of DOIs or Wikidata identifiers into a BibTeX file on the command line, to displaying RIS references on a webpage with added Altmetric badges to generating ”How to cite this” sections on a blog. The accuracy of conversions is currently 27% for properties and 60% for types on average and a typical initialization takes 120 ms in browsers and 1 s with Node.js on the command line.ConclusionsCitation.js is a library supporting various formats of bibliographic information in a broad selection of use cases and environments. Given the support for plugins, more formats can be added with relative ease.
Phosphorylation/dephosphorylation response to light stimuli of Symbiodinium proteins: specific light-induced dephosphorylation of an HSP-like 75 kDa protein from S. microadriaticum
Authors: Castillo-Medina Raúl E. , Islas-Flores Tania , Villanueva Marco A. 
Published: August 2019

Background
Some genera of the family Symbiodiniaceae establish mutualistic endosymbioses with various marine invertebrates, with coral being the most important ecologically. Little is known about the biochemical communication of this association and the perception and translation of signals from the environment in the symbiont. However, specific phosphorylation/dephosphorylation processes are fundamental for the transmission of external signals to activate physiological responses. In this work, we searched phosphorylatable proteins in amino acids of Ser, Thr and Tyr from three species of the family Symbiodiniaceae, Symbiodinium kawagutii, Symbiodinium sp. Mf11 and Symbiodinium microadriaticum.

Methods
We used specific antibodies to the phosphorylated aminoacids pSer, pThr and pTyr to identify proteins harboring them in total extracts from three species of Symbiodinium in culture. Extractions were carried out on logarithmic phase growing cultures under a 12 h light/dark photoperiod. Various light/dark, nutritional and other stimuli were applied to the cultures prior to the extractions, and proteins were subjected to SDS-PAGE and western immunoblotting. Partial peptide sequencing was carried out by MALDI-TOF on specific protein spots separated by 2D electrophoresis.

Results
At 4 h of the light cycle, several Thr-phosphorylated proteins were consistently detected in the three species suggesting a genus-dependent expression; however, most Ser- and Tyr-phosphorylated proteins were species-specific. Analysis of protein extracts of S. microadriaticum cultures demonstrated that the level of phosphorylation of two Thr-phosphorylated proteins with molecular weights of 43 and 75 kDa, responded inversely to a light stimulus. The 43 kDa protein, originally weakly Thr-phosphorylated when the cells were previously adapted to their 12 h dark cycle, underwent an increase in Thr phosphorylation when stimulated for 30 min with light. On the other hand, the 75 kDa protein, which was significantly Thr-phosphorylated in the dark, underwent dephosphorylation in Thr after 30 min of the light stimulus. The phosphorylation response of the 43 kDa protein only occurred in S. microadriaticum, whereas the dephosphorylation of the 75 kDa protein occurred in the three species studied suggesting a general response. The 75 kDa protein was separated on 2D gels as two isoforms and the sequenced spots corresponded to a BiP-like protein of the HSP70 protein family. The presence of differential phosphorylations on these proteins after a light stimulus imply important light-regulated physiological processes in these organisms.
Compras Sustentáveis: Proposta de Intervenção para as Compras Públicas Do IFPB – Campus Campina Grande
Authors: Cunha Silvan Freire , Araújo Maria Arlete Duarte 
Published: August 2019

Essa proposta de intervenção objetivou construir um modelo de compras para o IFPB – Campus Campina Grande, em consonância com a legislação ambiental vigente e com os pressupostos da sustentabilidade e proteção ao meio ambiente. Para construir um modelo de licitações sustentáveis adequado à realidade do IFPB – Campus Campina Grande, avaliou-se uma série de modelos implementados por instituições públicas federais e outros sugeridos por associações dedicadas à temática, além de uma ampla pesquisa na legislação federal que trata de licitações públicas. Como resultados, foram propostos a inclusão de critérios de sustentabilidade nos processos licitatórios, alterações nos editais licitatórios para adaptá-los à legislação ambiental, normas de implementação e métodos de avaliação dos resultados a serem alcançados para que as correções necessárias sejam efetuadas. Sugeriu-se a adoção de um modelo de edital licitatórios com critérios de sustentabilidade; criação de uma Comissão Gestora para o Plano de Gestão de Logística Sustentável; uma nova política de compras na instituição a partir de uma nova postura dos requisitantes; boa parte dos itens solicitados após as orientações, passaram a ser descritos com algumas características sustentáveis.
The Biosynthesis of Glucosinolates: Insights, Inconsistencies, and Unknowns
Authors: Bell Luke 
Published: August 2019

AbstractGlucosinolates (GSLs) and their hydrolysis products (GHPs) are of great interest within the scientific community. Isothiocyanates (ITCs) are one type of hydrolysis product that have efficacy against some forms of cancer and prevention of some neurodegenerative disorders. They can also have potent effects upon pests and diseases of crops and give rise to the characteristic tastes and flavours of many commonly consumed Brassicales crops. The genetic mechanisms underlying GSL biosynthesis and regulation of GHPs are well elucidated in the model organismArabidopsis thaliana, and research over the last fifteen years has also greatly expanded knowledge withinBrassicaspp. There are, of course, many hundreds of GSL‐producing species within the Brassicales order, with potentially very different and/or advanced mechanisms of GSL biosynthesis, metabolism, and catabolism. This article summarises the current understanding of GSL biosynthesis and highlights areas of exploration beyond the ‘ArabidopsisandBrassicabubble’ of GSL research. Novel GSLs, and the gene encoding proteins that regulate their biosynthetic pathways, could greatly enhance our knowledge of Brassicales phytochemistry, evolution, and natural history if given more attention.
Mass Transfer and Reaction Kinetic Enhanced Electrode for High‐Performance Aqueous Flow Batteries
Authors: Mukhopadhyay Alolika , Yang Yang , Li Yifan , Chen Yong , Li Hongyan , Natan Avi , Liu Yuanyue , Cao Daxian , Zhu Hongli 
Published: August 2019

AbstractA scalable and efficient process to modify electrodes with enhanced mass transfer and reaction kinetics is critical for redox flow batteries (RFBs). For the first time, this work introduces electrochemical exfoliation as a surface modification method of graphite felt (GF) to enhance the mass transfer and reaction kinetics in RFBs. Anion intercalation and subsequent gas evolutions at room temperature for one minute expand the graphite layers that increase the electrode surface area. Meanwhile, sufficient oxygen functional groups are introduced to the electrode, resulting in enhanced reaction kinetics and improved hydrophilicity. Further, spin‐polarized density functional theory is employed to reveal the role of oxygen functional groups in accelerating the vanadium redox reaction. Benefitting from sufficient oxygen groups, larger surface area, and superior wettability, the as‐prepared exfoliated GF (E‐GF) shows exceptional electrocatalytic activity with minimized overpotential, higher volumetric capacity, and improved energy efficiency. The redox flow battery assembled with the E‐GF electrode delivers voltage and energy efficiencies of 89.72% and 86.41% at the current density of 100 mA cm−2, respectively. Remarkably, compared to the traditional GF treatment method, the elimination of the high temperature and long‐time treatment processes make this approach much more energy and time efficient, scalable, and affordable for large‐scale manufacturing.