bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth performance of nursery pigs fed diets containing increasing levels of a novel high-protein corn distillers dried grains with solubles1
Authors: Yang Zhaohui , Urriola Pedro E , Hilbrands Adrienne M , Johnston Lee J , Shurson Gerald C 
Published: September 2018

AbstractThe objective of this study was to use the recently determined ME and standardized ileal digestibility (SID) values of AA for a novel high-protein distillers dried grains with solubles (HP-DDGS; PureStream 40, Lincolnway Energy LLC, Nevada, IA) to determine the optimal dietary inclusion rates in diets for nursery pigs. Three hundred and sixty pigs (BW = 6.79 ± 0.02 kg) were blocked by BW, and pens within blocks were assigned randomly to one of four dietary treatments (10 pens/treatment, 9 pigs/pen). Dietary treatments consisted of adding 0%, 10%, 20%, or 30% HP-DDGS to nursery diets during phase 2 (days 7–21) and phase 3 (days 21–42) of a three-phase nursery feeding program. Diets within each phase were formulated to contain equivalent amounts of ME, SID Lys, Met, Thr, and Trp, Ca, standardized total tract digestible P, vitamins, and trace minerals. Calculated SID Leu to Lys ratios for 0%, 10%, 20%, and 30% HP-DDGS diets were 119%, 137%, 156%, and 173% in phase 2 diets and 120%, 131%, 143%, and 160% in phase 3 diets. The SID Ile to Lys ratios ranged from 60% to 69% in phase 2 diets and from 54% to 59% in phase 3 diets. The SID Val to Lys ratios ranged from 63% to 79% in phase 2 diets and 64% to 68% in phase 3 diets. Body weight and feed disappearance were measured weekly. During phase 2, ADG, ADFI, and G:F were reduced linearly (P &lt; 0.01) as the diet inclusion rate of HP-DDGS increased. Similarly in phase 3, increasing dietary levels of HP-DDGS depressed ADG, ADFI, and G:F linearly (P &lt; 0.01). Overall growth performance of phases 2 and 3 of nursery pigs was negatively affected by increasing levels of HP-DDGS in these diets. Pigs acquired a Streptococcus suis and Escherichia coli disease challenge during the experiment. Although no differences in morbidity were observed throughout the experiment, including HP-DDGS in diets tended to decrease (P = 0.08) mortality. In conclusion, a linear decrease in nursery pig growth performance was observed as increasing levels of HP-DDGS were added in diets, which was probably due to overestimation of SID AA content of the HP-DDGS, antagonistic effects of excess Leu, and the effects of relatively high fiber content.
Promoting Successful Aging Through Faith Community Nursing
Authors: Hixson Lina B. , Loeb Susan J. 
Published: September 2018

ABSTRACT:
Promotion of successful aging is imperative for the growing population of U.S. adults 65 and older, who will outnumber those 18 and under by 2035. Faith community nurses (FCNs) provide interventions targeting health promotion and disease prevention, with a focus on faith and health. This study examined the most frequently documented interventions and attended services provided to older adults by FCNs. A secondary analysis of data from the web-based Henry Ford Macomb Hospital Faith Community Nursing/Health Ministries Documentation and Reporting System reveals how FCNs are contributing to successful aging.
Helping Bridge the Great Divides
Authors: Lee Sondra B. , Forehand Jeffery W. , St. Onge Judith L. , Acker Kristi A. 
Published: September 2018

ABSTRACT:
Many, especially newer, nurses lack the experience for nuanced skillful communication at end of life. This study incorporated the End-of-Life Nursing Education Consortium (ELNEC) Core Curriculum Communication module into a nurse residency program and tested for change in attitudes toward end-of-life (EOL) care. Researchers found significant differences in attitudes toward care of the dying before and after the ELNEC training, and between nurses with greater than and less than 5 years experience. Findings support that ELNEC education can significantly impact nurse attitudes about EOL care.
A Prospective Study of Immediate Breast Reconstruction with Laser-Assisted Indocyanine Green Angiography
Authors: Mirhaidari Shayda J. , Beddell Gregory M. , Orlando Marc V. , Parker Michael G. , Pedersen John C. , Wagner Douglas S. 
Published: September 2018

Background:
Complication rates following immediate breast reconstruction range from 4% to 60%. Mastectomy skin flap necrosis (MSFN) is often the sentinel event leading to secondary complications.

Methods:
All patients undergoing immediate reconstruction were enrolled. Upon mastectomy completion, the surgeon visually interpreted the skin flaps, performed laser-assisted indocyanine green angiography (LAIGA), and intervened if needed. Patients were followed for 90 days, documenting skin necrosis, infection, seroma, hematoma, implant loss, and reoperation.

Results:
There were 126 patients who had 206 immediate breast reconstructions. The complication rate was 22.3%. The incidence of MSFN was 14.1%. The reoperation rate was 8.7%. There was 1 necrosis-related implant loss. Postoperative surveys were completed on 193 breasts: 137 had visual and LAIGA interpretation of well or adequately perfused, resulting in 5.8% rate of necrosis, 2 reoperations, and no implant losses. Twenty breasts had visual and LAIGA interpretation of marginal or poor perfusion. Sixteen of these underwent intervention. The necrosis rate in this group was 35% with no implant losses. A third group with 26 breasts had adequate visual interpretation with marginal or poor perfusion on LAIGA. Ten breasts had no intervention, and 16 received intervention. The overall necrosis rate in this group was 42.3%, with 4 reoperations for necrosis and 1 implant loss.

Conclusions:
LAIGA can more accurately predict complications from MSFN than surgeon assessment alone. When surgeon decision making is supplemented with LAIGA, it reduces the incidence of MSFN, infection, implant loss, and overall unexpected reoperation rate. LAIGA is a valuable adjunct for intraoperative decision making.
RANIBIZUMAB IN PIGMENT EPITHELIAL TEARS SECONDARY TO AGE-RELATED MACULAR DEGENERATION
Authors: Larsen Petra P. , Oishi Akio , Bedar Mohammad Seleman , Heymer Philipp K. R. , Clemens Christoph R. , König Susanna , Gutfleisch Matthias , Pauleikhoff Daniel , Eter Nicole , Wolf Armin , Holz Frank G. , Krohne Tim U. 
Published: September 2018

Purpose:
To assess efficacy of intravitreal ranibizumab in retinal pigment epithelium tears secondary to neovascular age-related macular degeneration.

Methods:
The Ranibizumab In Pigment epithelial tears secondary to age-related macular degeneration (RIP) study is a prospective, single-arm, multicenter, investigator-initiated trial. Twenty four eyes of 24 patients with a retinal pigment epithelium tear secondary to age-related macular degeneration received monthly intravitreal injection of 0.5mg ranibizumab for 12 months, together with monthly assessments of morphologic and functional efficacy parameters. Primary outcome measure was mean best-corrected visual acuity at final visit compared with baseline.

Results:
Mean best-corrected visual acuity remained stable over the 12-month study period with 50.3 Early Treatment of Diabetic Retinopathy Study letters (±18.7; Snellen equivalent 20/100) at baseline and 52.9 letters (±19.7; Snellen equivalent 20/100) at final visit (P = 0.39). One eye (4%) experienced a vision loss of ≥15 letters, and 2 eyes (8%) gained ≥15 letters. Mean central retinal thickness decreased from 571 µm (±185 µm) to 436 µm (±171 µm; P = 0.0001). Vision-related quality of life was stable with a mean VFQ-25 score of 79.0 (±10.8) at baseline and 74.3 (±13.9) at final visit (P = 0.12).

Conclusion:
In retinal pigment epithelium tears secondary to age-related macular degeneration, monthly intravitreal ranibizumab therapy results in stabilization of visual acuity over 12 months.
Color Doppler Flow Imaging of Retrobulbar Ocular Blood Flow Changes in Retinal Artery Occlusions Caused by Cosmetic Facial Filler Injections
Authors: Huang Peijie , Liu Ailin , Ren Hui , Xue Kang 
Published: September 2018

Purpose:This study aimed to evaluate the effects of retinal artery occlusions caused by cosmetic facial filler injections on the retrobulbar blood flow parameters.Methods:This was a retrospective, noncomparative case series. Ten consecutive patients with fundus artery occlusions caused by facial filler injections were evaluated using color Doppler flow imaging (CDFI). The peak systolic velocity and end diastolic velocity of the ophthalmic artery, central retinal artery, and posterior ciliary arteries were determined. The clinical features, including the filler material, injection site, best-corrected visual acuity, fundus fluorescein angiography, and associated ocular and systemic manifestations were also collected.Results:Injected materials included autologous fat (7 cases) and hyaluronic acid (3 cases). In 6 of the patients with ophthalmic artery occlusions, the CDFI showed no or drastic declines in the retrobulbar blood flow in the ophthalmic artery, central retinal artery, and posterior ciliary arteries. In 3 of the patients with central retinal artery occlusions, the CDFI showed no or a grossly decreased retrobulbar blood flow in the central retinal artery. In one patient with anterior ischemic optic neuropathy, the CDFI showed decreased end diastolic velocities and increased pulsatility and resistance indices in the central retinal artery, posterior ciliary arteries, and ophthalmic artery. During the follow-up period, the retrobulbar blood flow recovered to some degree. Overall, ophthalmic artery occlusion patients receiving autologous fat may have neurologic complications.Conclusions:The results suggest that the retrobulbar ocular blood flows measured with CDFI were distinctly different in the different types of ophthalmic artery occlusion. Color Doppler flow imaging could provide a practicable and convenient method for the diagnosis and follow up of retinal artery occlusions caused by cosmetic facial filler injections.
A Systematic Review of Criteria-Led Patient Discharge
Authors: Lees-Deutsch Liz , Robinson Jane 
Published: September 2018

Background:
This article reports on a systematic review conducted to critique safety, quality, length of stay, and implementation factors regarding criteria-led discharge.

Purpose:
Improving patient flow and timely bed capacity is a global issue. Criteria-led discharge enables accelerated patient discharge in accordance with patient selection.

Methods:
A systematic review was conducted to identify literature on criteria-led discharge from 2007 to 2017. The quality of articles was appraised using a tool for disparate studies. Two reviewers extracted relevant data independently.

Results:
Fifteen studies were identified that showed no increase in patient readmission or complication rates with criteria-led discharge, demonstrating patient safety. The quality of the patient discharge was unremarkable. None of the studies showed an increase in length of stay.

Conclusions:
The safety, quality, and length of stay for patients discharged through criteria-led discharge are inextricably linked to the process adopted for its implementation.
Precipitating events in child and adolescent chronic musculoskeletal pain
Authors: Becker Andrew J. , Heathcote Lauren C. , Timmers Inge , Simons Laura E. 
Published: September 2018

Abstract

Introduction:
The epidemiology of chronic pain in youth has been increasingly documented over the past decade. However, the precipitating events associated with the onset of pediatric chronic pain are not well studied.

Objectives:
Understanding the events that precede the onset of pain, and are reported by patients as germane to the early stages of their pain, may add one piece to the puzzle of the causal etiology of pediatric chronic pain disorders.

Methods:
We conducted a retrospective chart review of 320 young people attending a tertiary care chronic pain clinic with musculoskeletal chronic pain.

Results:
Approximately two-thirds of patients reported a precipitating event for their pain; injury was the most commonly reported event, followed by a chronic disease, then an infection or illness. Surgery was the least commonly reported event. About one-third of patients did not report any precipitating event for their pain. Patients with neuropathic pain were even more likely to report a precipitating event compared to those with localized and diffuse musculoskeletal pain. Patients with localized musculoskeletal pain and neuropathic pain were most likely to report an injury, whereas patients with diffuse musculoskeletal pain were most likely to report a chronic disease. We found little to no evidence that the presence or type of precipitating event was associated with patients' psychological or physical functioning.

Conclusion:
This study adds to the epidemiological evidence base for pediatric chronic pain disorders.
Intergenerational examination of pain and posttraumatic stress disorder symptoms among youth with chronic pain and their parents
Authors: Beveridge Jaimie K. , Neville Alexandra , Wilson Anna C. , Noel Melanie 
Published: September 2018

Abstract

Introduction:
Posttraumatic stress disorder (PTSD) symptoms are prevalent among youth with chronic pain, and associated with poorer pain outcomes and health-related quality of life (HRQoL). Conceptual models suggest that parent factors, including parents' own chronic pain, may be linked to higher co-occurring pain and PTSD symptoms and lower HRQoL in children. However, this has not been empirically examined.

Objectives:
The aim of this study was to examine the relationship between parental chronic pain and (1) parent PTSD symptoms, (2) child PTSD symptoms, (3) child pain outcomes, and (4) child HRQoL in a sample of treatment-seeking youth with chronic pain and their parents.

Methods:
Youth (n = 173) aged 8 to 18 years and parents (n = 204) recruited from a tertiary-level pediatric chronic pain program completed psychometrically-sound measures of pain and PTSD symptoms. Youth also completed measures of pain interference and HRQoL.

Results:
Half of the parents in this sample reported chronic pain. A series of analyses of covariances revealed that parents with vs without chronic pain reported significantly higher PTSD symptoms, and children of parents with vs without chronic pain reported significantly higher PTSD symptoms and pain interference and lower HRQoL.

Conclusion:
Findings from this study suggest that having a parent with chronic pain may confer additional risk for children with chronic pain experiencing higher PTSD symptoms, poorer pain outcomes, and lower HRQoL than having a parent without chronic pain. This could be due to genetics or social learning. Future longitudinal research is needed to understand how parental pain influences co-occurring pain and PTSD symptoms, and HRQoL, in children.
Conceptualizing pain-related stigma in adolescent chronic pain: a literature review and preliminary focus group findings
Authors: Wakefield Emily O. , Zempsky William T. , Puhl Rebecca M. , Litt Mark D. 
Published: September 2018

Abstract

Introduction:
Chronic pain in adolescents is a significant medical condition, affecting the physical and psychological well-being of youth and their families. Pain-related stigma is a significant psychosocial factor in adolescents with chronic pain that has been understudied, despite its implications for negative health outcomes, poor quality of life, and increased healthcare utilization.

Objectives:
To examine pain-related stigma in the literature documenting pediatric and adult health-related stigma and present preliminary findings from a focus group of adolescents with chronic pain.

Methods:
In this narrative review, we explored pain-related stigma research and conceptualized the literature to address pain-related stigma among adolescents with chronic pain. Additionally, we conducted a focus group of four adolescent females with chronic pain and using content analyses, coded the data for preliminary themes.

Results:
We propose a pain-related stigma model and framework based on our review and the findings from our focus group. Findings suggest that medical providers, school personnel (ie, teachers and school nurses), peers and even family members enact pain-related stigma toward adolescents with chronic pain.

Conclusions:
Based on this narrative review, there is preliminary evidence of pain-related stigma among adolescents with chronic pain and future research is warranted to better understand the nature and extent of this stigma within this population.
Defence response mobilization in response to provocation or imagery of interoceptive sensations in adolescents with chronic pain: a study protocol
Authors: Gruszka Piotr , Schaan Luca , Adolph Dirk , Pané-Farré Christiane A. , Benke Christoph , Schneider Silvia , Hechler Tanja 
Published: September 2018

Abstract

Introduction:
Fear of pain seems to be a key factor in the development and maintenance of chronic pain and pain-related disability. Interoceptive fear conditioning is assumed to constitute an important mechanism in the origins and maintenance of fear of pain. If conditioned stimuli such as internal bodily sensations are repeatedly paired with pain (unconditioned stimulus), they in turn elicit a conditioned fear response, including defence mobilization such as startle modulation and changes in heart rate and electrodermal activity. Research into emotional imagery suggests that defensive responses can also be elicited through imagery of fear scripts.

Objectives:
We present 2 novel paradigms adapted from research on anxiety disorders, which allow to test, if perceived or imagined sensations locally proximal to the main pain location trigger heightened defence response mobilization in adolescents with chronic headaches and abdominal pain.

Methods:
The provocation paradigm includes the anticipation and provocation of locally proximal and locally distal interoceptive sensations through disorder-specific muscle tensing tasks (tightening the neck or the abdominal muscles). The imagery paradigm includes 3 imagery scripts (standard neutral, standard fear, and disorder-specific). Startle probes are presented in both paradigms. Defence response mobilization is assessed using psychophysiological measures (startle response modulation, skin conductance level, and heart rate), as well as self-reported measures of fear.

Perspective:
The paradigms will give insight into the defence response of adolescents with chronic pain, when confronted with or imagining interoceptive sensations. Results may inform the improvement of clinical interventions aimed to decrease fear of bodily sensations such as interoceptive exposure or interoceptive imagery exposure.
Interpretable and Accurate Prediction Models for Metagenomics Data
Authors: Prifti Edi , Chevaleyre Yann , Hanczar Blaise , Belda Eugeni , Danchin Antoine , Clément Karine , Zucker Jean-Daniel 
Published: September 2018

ABSTRACTBiomarker discovery using metagenomic data is becoming more prevalent for patient diagnosis, prognosis and risk evaluation. Selected groups of microbial features provide signatures that characterize host disease states such as cancer or cardio-metabolic diseases. Yet, the current predictive models stemming from machine learning still behave as black boxes. Moreover, they seldom generalize well when learned on small datasets. Here, we introduce an original approach that focuses on three models inspired by microbial ecosystem interactions: the addition, subtraction, and ratio of microbial taxon abundances. While being extremely simple, their performance is surprisingly good and compares to or is better than Random Forest, SVM or Elastic Net. Such models besides being interpretable, allow distilling biological information of the predictive core-variables. Collectively, this approach builds up both reliable and trustworthy diagnostic decisions while agreeing with societal and legal pressure that require explainable AI models in the medical domain.
Replicated point processes with application to population dynamics models
Authors: Favretti Marco 
Published: September 2018

AbstractIn this paper we study spatially clustered distribution of individuals using point process theory. In particular we discuss the spatially explicit model of population dynamics of Shimatani (2010) which extend previous works on Malécot theory of isolation by distance. We reformulate Shimatani model of replicated Neyman-Scott process to allow for a general dispersal kernel function and we show that the random immigration hypothesis can be substituted by the long dispersal distance property of the kernel. Moreover, the extended framework presented here is fit to handle spatially explicit statistical estimators of genetic variability like Moran autocorrelation index, Sørensen similarity index, average kinship coefficient. We discuss the pivotal role of the choice of dispersal kernel for the above estimators in a toy model of dynamic population genetics theory.
Resting-state fMRI data of awake dogs (Canis familiaris) via group-level independent component analysis reveal multiple, spatially distributed resting-state networks
Authors: Szabό Dόra , Czeibert Kálmán , Kettinger Ádám , Gácsi Márta , Andics Attila , Miklόsi Ádám , Kubinyi Enikő 
Published: September 2018

ABSTRACTResting-state networks are spatially distributed, functionally connected brain regions. Studying these networks gives us information about the large-scale functional organization of the brain and alternations in these networks are considered to play a role in a wide range of neurological conditions and aging. To describe resting-state networks in dogs, we measured 22 awake, unrestrained animals of either sex and carried out group-level spatial independent component analysis to explore whole-brain connectivity patterns. Using resting-state functional magnetic resonance imaging (rs-fMRI), in this exploratory study we found multiple resting-state networks in dogs, which resemble the pattern described in humans. We report the following dog resting-state networks: default mode network (DMN), visual network (VIS), sensorimotor network (SMN), combined auditory (AUD)-saliency (SAL) network and cerebellar network (CER). The DMN, similarly to Primates, but unlike previous studies in dogs, showed antero-posterior connectedness with involvement of hippocampal and lateral temporal regions. The results give us insight into the resting-state networks of awake animals from a taxon beyond rodents through a non-invasive method.