bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of experimental knee pain location on gait kinematics
Authors: Gallina Alessio , Adamo Paola , Marino Giorgia , Cescon Corrado , Bolzoni Francesco , Barbero Marco , Temporiti Federico , Gatti Roberto 
Published: November 2024

Abstract
Purpose
In this study, we investigated whether experimental knee pain alters lower limb kinematics and knee arthrokinematics during gait, and if this motor adaptation depends on the spatial characteristics of the painful stimulus.

Methods
Twenty-one participants walked on a treadmill for 60-s trials, either without stimulation or while experiencing painful electrical stimulation in the medial, lateral or anterior region of the knee. Perceived pain location was analyzed using pain drawing. Gait spatiotemporal parameters, lower limb kinematics, and dispersion of the knee helical axes on the sagittal plane were quantified for each trial and compared between conditions using ANOVAs with repeated measures or Friedman tests.

Results
Pain perception was localized in the area the stimulation was applied to. Compared to walking without pain, participants demonstrated reduced knee extension (1.5 ± 1.5 degrees, p = 0.002) and reduced hip extension (0.8 ± 1.1 degrees, p = 0.037) when pain was induced in the anterior region, but not medially or laterally. Anterior knee pain increased the mean distance of the helical axes during late stance (0.7 [0.3, 1.4], p = 0.010), while medial pain increased both mean distance (0.3 [0.1, 0.5], p = 0.037) and mean angle (1.2 ± 1.4, p = 0.010) during early swing.

Conclusion
Acute, experimental knee pain alters gait kinematics and increases the dispersion of the helical axis. These adaptations depend on the spatial characteristics of the painful stimulus. These adaptations may reflect an attempt of the central nervous system to protect the painful tissue while searching for a less painful movement strategy.
Acute exercise impacts heart rate variability but not cognitive flexibility during subsequent simulated firefighter occupational tasks
Authors: Agostinelli Philip J. , Bordonie Nicholas C. , Linder Braxton A. , Robbins Ann M. , Jones Parker L. , Reagan Lee F. , Mobley C. Brooks , Miller Matthew W. , Murrah William M. , Sefton JoEllen M. 
Published: November 2024

Abstract
Purpose
Acute exercise can transiently enhance cognitive flexibility. The cognitive demand of firefighters makes it relevant to understand if on-shift exercise could produce similar improvements in cognitive performance during subsequent occupational tasks. Metrics of heart rate variability (HRV), such as time- and frequency-domain outcomes, may shed light upon the influence exercise has on cognition, as they discern information related to cardiac autonomic (sympathetic/parasympathetic) function. We aimed to determine if acute resistance and aerobic exercise impact cognitive flexibility during occupational tasks and its relation to HRV.

Methods
32 participants completed a baseline Wisconsin Card Sorting Task (WCST) and three experimental trials: resistance exercise (RE), aerobic exercise (AE), or a rested control (CON). An occupational task assessment (OTA) including four rounds of 10 deadlifts and a 0.15-mile sandbag carry in an environmental chamber (35 °C/50% humidity) was completed after each trial. The second round was followed by the WCST. Repeated measures ANOVAs were used to analyze differences by condition.

Results
For the WCST, total, perseverative, and non-perseverative errors did not differ (ps > 0.39). Time-domain HRV metrics were not different (ps > 0.05). All frequency-domain metrics, other than low-frequency power, were not different (ps > 0.24). Low-frequency power was lower based on condition (p = 0.03). Post hoc analysis showed low-frequency power was lower following AE compared to RE and CON.

Conclusion
Results suggest an acute bout of on-shift aerobic or resistance exercise may not impact cognitive flexibility during subsequent simulated occupational tasks, despite depressed metrics of heart rate variability following aerobic exercise.
Sensitive and reliable detection of KIT p.D816V mutation in decalcified archival bone marrow trephines
Authors: Odensass Miriam , Bartels Stephan , Schlue Jerome , Büsche Guntram , Kreipe Hans H. , Lehmann Ulrich 
Published: November 2024

AbstractThe majority of mastocytosis cases are characterized by an activating mutation in the KIT gene in codon 816. The detection of this alteration is of importance for proper diagnostic workup. Therefore, reliable and sensitive methods for the detection of KIT Codon 816 hotspot mutations in various types of patient samples are required. Since mutated cancer genes are often overexpressed, we evaluated the feasibility and sensitivity of KIT p.D816V detection by analysing mRNA/cDNA instead of genomic DNA. From 80 bone marrow trephines harboring a KIT p.D816 mutation, seven were only mutated by mRNA/cDNA pyrosequencing and 11 only by digital PCR analysis of genomic DNA. These results clearly demonstrate that detection of clinically relevant mutations in mRNA extracted from routinely processed decalcified archival bone marrow trephines is not only possible in a reliable fashion but under many circumstances advantageous. This enables the direct correlation of genomic data with high-quality morphological evaluation.
Definition of reproductive structures in Eucalyptus for phenological data collection
Authors: Giraldo Escobar Claudia Helena , Keatley Marie R. , Kasel Sabine , Di Stefano Julian , Nitschke Craig R. 
Published: November 2024

AbstractIn an era where global climate change is shifting plant phenology, global meta-analyses of multiple species are required more than ever. Common language or references for enhanced data compatibility are key for such analyses. Although the Plant Phenology Ontology (PPO) addresses this challenge, it does not capture several relevant reproductive structures that are critical in species with long reproductive cycles, like many Eucalyptus species. We reviewed the terminology and concepts that describe reproductive structures in eucalypts and compared them with the existing classes of the PPO to explore the PPO’s potential for harmonizing disparate eucalypt datasets. We identified incongruencies within and between eucalypt terminology and the PPO. We tested the sensitivity of the PPO for capturing key eucalypt phenological structures and found it sensitive to classification of certain structures. To address these limitations, we developed the Eucalyptus Phenology Ontology (EPO), a new ontology that builds on the PPO and captures key reproductive structures using a more refined classification. The EPO integrates the relationships between reproductive structures, phenological stages, and phenological traits. The vocabulary is species-neutral so it can be applied to other taxa but specifies the synonyms and descriptions required to capture the complexity of eucalypt phenology.
Physicians’ perspectives on cancer-related fatigue management and their suggestions for improvements in medical training: a cross-sectional survey study in Germany
Authors: Wagner Anna S. , Wehlen L. , Milzer Marlena , Schmidt Martina E. , Kiermeier Senta , Maatouk Imad , Steindorf Karen 
Published: November 2024

Abstract
Purpose
Contrary to guidelines, many cancer patients are not screened for cancer-related fatigue (CRF) and do not receive information or adequate treatment. As physicians play a key role in cancer therapy, their knowledge of this common sequela and perspectives on its management are of major interest.

Methods
For an online survey, physicians working in oncology in Germany were systematically drawn from registers and invited by using institutional newsletters or colleagues. Descriptive analyses, logistic regression analysis of physicians’ knowledge, and Mann‒Whitney U tests were performed.

Results
Two-thirds of the 148 surveyed physicians felt (rather) well informed about CRF and capable of counseling patients. Only 32% of the sample were aware of CRF-specific guidelines. Despite of this, participants rated the scientific evidence for recommending physical activity, exercise programs, and psychotherapeutic interventions in accordance with guidelines as being mostly (very) strong. However, despite 82.4% of the physicians being (rather) aware of its evidence, only 56.1% often to almost always recommended psychotherapeutic interventions. CRF was rarely covered in medical studies and medical specialist training. The completion of advanced training for palliative care increased the likelihood of knowing guidelines (OR = 2.6, 95% CI [1.1–6.0], p < 0.05). Suggestions for improving training included the mandatory coverage of CRF in medical training or its consideration in interprofessional supportive care workshops.

Conclusion
Although awareness and recommendation rates were adequate for some interventions in CRF treatment (such as physical activity), there were lower recommendation rates for others, including psychotherapy. Studies are required assessing for the reasons of this knowledge-to-practice gap. Moreover, training is needed among physicians in order to enhance knowledge of CRF guidelines.

Trial registration
Clinicaltrials.gov, identifier: NCT04921644. Registered in June 2021.
Benefits of applying standardized frameworks to implement psychosocial tools such as the ‘My Logbook’
Authors: Weiler-Wichtl Liesa J. , Fohn-Erhold Verena , Rosenmayr Verena , Hansl Rita , Hopfgartner Maximilian , Pal-Handl Katharina , Wasinger-Brandweiner Verena , Herzog Kristina , Neumann Kirsten , Schellenberg Tobias , Schönenberger-Loppacher Dorothee , Faist-Schweika Christiane , Schönthaler Barbara , Budich Mihaela , Stember Nicole , Wiegele Karin , Reddig Maike , Paduch Anne , Lein-Köhler Iris , Görgen Sonja , Wienands Heike , Gauf Hiltrud , Hoffmann Rahel , Kollmann Alina , Just Ulrike , Salzmann Nicole , Neunsinger Petra , Gerhardt Marina , Essl Stefanie , Borbely Janina , Köpper Manuel , Rinner Sarah , Schubert Lisa , Leiss Ulrike 
Published: November 2024

Abstract
Purpose
Evidence-based interventions (EBIs) are essential to improve the well-being and neurocognitive outcomes of pediatric cancer patients; however, considerable barriers hamper the implementation of these tools. The present study assessed health care professionals’ (HCP) perceived barriers and facilitators to the implementation of a specific EBI for pediatric oncology in a standardized manner to define effective solutions and practical recommendations.

Methods
An adapted version of the Consolidated Framework for Implementation Research (CFIR) questionnaire was applied to inquire n = 31 HCPs in pediatric oncology about the five domains of implementation.

Results
While most ‘intervention characteristics’ were considered beneficial for implementation, various aspects of the ‘inner’ and ‘outer setting’ were considered problematic. The most prevalent barriers included a shortage in resources, poor integration of EBIs into policies and lacking incentives such as user benefits. Concrete proposed and realized steps to facilitate effective implementation include a patient-focused design and continuous evaluation and adaption of the tool, a detailed EBI user manual and application workshops, as well as regular interdisciplinary meetings to improve communication. Regarding the internal and external settings, involving policy makers, establishing psychosocial care in the insurance system and increasing awareness by sharing evidence are essential steps for improved implementation.

Conclusion
Based on standardized implementation evaluation, various targeted actions could be defined and implemented to facilitate successful implementation of EBIs in pediatric oncology. The results emphasize that psychosocial care must become an integral part of treatment standards and public health policies to ensure that effective psychosocial interventions for improved wellbeing and neurocognitive skills successfully reach pediatric cancer patients.

Trial registration number
ClinicalTrials.gov Identifier: NCT04474678 (July 17th 2020).
Effect of therapeutic exercise on peak oxygen consumption in oncological population: a systematic review with meta-analysis
Authors: del-Rosal-Jurado Alicia , González-Sánchez Manuel , Cuesta-Vargas Antonio Ignacio 
Published: November 2024

Abstract

Introduction
Cancer is amongst the leading causes of death worldwide. A total of 19.3 million new cases were diagnosed in 2020. Cardiovascular impairment is the second leading cause of death in patients undergoing cancer treatment. By measuring the maximum rate of oxygen consumption (VO2max) in cancer patients, it is possible to estimate their cardiorespiratory health. This study aims to show how participants’ VO2max increases with a therapeutic physical exercise programme.

Methods
Four databases were used for the literature search. Twenty-eight studies were analysed using the inclusion and exclusion criteria. The quality of these studies was analysed with the PEDRO scale. The structural characteristics of the articles and the study variable (VO2max) were studied.

Results
The VO2max of the 2558 patients studied presents some variations by gender, intervention and moment of measurement. For male-associated cancer, the increased VO2max ranged between 1.5 and 4.2% after the intervention. The increase in the maximum VO2max in female-associated cancer was between 0.3 and 53%. Different types of cancer for both genders presented an oscillation between 0.5 and 3.47%.

Conclusions
Therapeutic physical exercise is an efficient intervention to improve the VO2max in oncology patients. The results show that a therapeutic physical exercise intervention lasting 12 weeks, 3 days per week with a moderate-vigorous intensity, increases the VO2max in oncology patients.
Learning curve of consolers and bedside surgeons fused robotic-assisted thoracoscopic segmentectomy: insights from the initial 100 cases
Authors: Uno Yuki , Tane Shinya , Tanaka Yugo , Takanashi Midori , Doi Takefumi , Ogawa Hiroyuki , Hokka Daisuke , Maniwa Yoshimasa 
Published: November 2024

Abstract
Purpose
This study examined the learning curve of segmentectomy using the “fused surgery” approach.

Methods
We retrospectively collected data from 100 patients who underwent segmentectomy via fused robot-assisted thoracoscopy at our institution between September 2020 and February 2024. The learning curve was evaluated using the cumulative sum of the operative times in all cases and was analyzed separately for simple and complex segmentectomies.

Results
After applying the cumulative sum method to all cases, we obtained a graph of the operative time that showed three well-differentiated phases: phase 1 (n = 23), the initial learning phase; phase 2 (n = 28), the increased competence phase; and phase 3 (n = 49), the highest skill phase. Comparing phases 1 and 2 with phase 3, we found significant differences in operative time (P < 0.001); however, no significant differences were observed in bleeding or rate of postoperative complications. We observed a significant reduction in operative time after 25 simple segmentectomies and 22 complex segmentectomies.

Conclusions
The data suggested that the inflection point of the learning curve was achieved in 51 cases. Complex segmentectomy requires the same cases to achieve the same level of competence as simple segmentectomy.
A Geometrically Motivated Two-Dimensional Collisional Abrasion Model to Resolve the Evolution of Natural Fragment Shapes
Authors: Havasi-Tóth Balázs , Fehér Eszter 
Published: November 2024

Abstract
In the present paper we propose a geometrically motivated mathematical model, which reveals the key features of natural coastal and fluvial fragment shape evolution from the earliest stages of the abrasion. Our collisional polygon model governs the evolution through an ordinary differential equation (ODE), which determines the rounding rate of initially sharp corners in the function of the size reduction of the fragment. As an approximation, the basic structure of our model adopts the concept of Bloore’s partial differential equation (PDE) in terms of the curvature-dependent local collisional frequency. We tested our model under various conditions and made comparisons with the predictions of Bloore’s PDE. Moreover, we applied the model to discover and quantify the mathematical conditions corresponding to typical and special shape evolution. By further extending our model to investigate the self-dual and mixed cases, we outline a possible explanation of the long-term preservation of initial pebble shape characteristics.
Spontaneous brain abscess formation: challenge of a shifting pathogen spectrum over the last 21 years – a single center experience
Authors: Kraus Luisa Mona , Overstijns Manou , Rahal Amir El , Behringer Simon , Buttler Klaus-Jürgen , Andereggen Lukas , Beck Jürgen , Schnell Oliver , Hornuss Daniel , Wagner Dirk , Cipriani Debora 
Published: November 2024

Abstract

Background
Spontaneous intracerebral abscess formation is a rare condition presenting with a disabling sequela. The origin of infection can either be primary or secondary to an infection at another location. The site of primary infection - due to the proximity, often the oral cavity, the sinuses, and the orbit - determines the causative pathogens. Treatment often combines surgical and antimicrobial therapies. To determine the microbiology and respective changes and treatment outcome, we performed this retrospective monocentric cohort study of patients requiring surgical treatment of brain abscesses.

Methods
Patients undergoing surgical treatment of a primary intracranial abscess between January 2000 and January 2021 in the Department of Neurosurgery, Freiburg University Hospital were included. Demographic, clinical and imaging data were extracted from patients’ medical records and databases. Treatment approaches were also analyzed, and surgical therapy and antibiotic therapy were reported. Outcome was assessed by the modified Rankin score (mRS) and was dichotomized into good (mRS 0–3) and poor (mRS 4–6) outcome.

Results
We included 65 patients with spontaneous intracerebral abscess that were treated with neurosurgical intervention at our institution. Analysis of the causative pathogens showed an increasing dominance of rare pathogens such as fungi, parasites, mycobacteria and anaerobes. Outcome measured by the mRS was similar from 2005 to 2021.

Conclusions
The pathogen spectrum of spontaneous intracerebral abscess at our institution is shifting with rarer pathogens being increasingly detected. This retrospective analysis highlights the need for microbiological diagnosis and of combined surgical and antibiological treatment.
Efficacy and safety of safinamide in Parkinson’s disease patients with motor fluctuations without levodopa dosage escalation over 18 weeks: KEEP study
Authors: Oh Eungseok , Cheon Sang-Myeong , Cho Jin Whan , Sung Young Hee , Kim Joong-Seok , Shin Hae-Won , Kim Jong-Min , Park Mee Young , Kwon Do-Young , Ma Hyeo , Park Jeong-Ho , Koh Seong-Beom , Choi Seong-Min , Park Jinse , Lee Phil Hyu , Ahn Tae-Beom , Kim Sang Jin , Lyoo Chul Hyoung , Lee Ho-Won , Kim Jieun , Lee Yoona , Baik Jong Sam 
Published: November 2024

Abstract
This multicentre, prospective, single-arm study evaluated safinamide as add-on therapy to levodopa in Korean patients with Parkinson’s disease (PD) with motor fluctuations with ≥ 1.5 h of “off” time daily, who took levodopa ≥ 3 times/day (n = 199). Baseline levodopa and dopamine agonist doses were maintained without escalation during the 18-week treatment period. Participants received safinamide 50 mg/day for 2 weeks and 100 mg/day thereafter. PD diaries and questionnaires (Parkinson’s Disease Questionnaire, PDQ-39; Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale, MDS–UPDRS part 3 and part 4; King’s Parkinson’s Disease Pain Scale, KPPS; Mini-Mental State Examination, MMSE) were assessed at baseline and at week 18. Treatment-emergent adverse events (TEAEs) were recorded. Mean disease duration was 6.6 years, and mean levodopa equivalent daily dose was 721.1 mg/day. At week 18, significant improvements from baseline were seen for the co-primary endpoints, mean daily “off” time (− 1.3 ± 2.4 h, p < 0.001) and quality of life (QoL) based on PDQ-39 summary index (− 2.7 ± 10.3, p < 0.001), Moreover, significant improvements were seen in motor symptoms and motor complications (MDS-UPDRS part 3 and 4), daily “on” time without dyskinesia (all p < 0.001) and pain (KPPS; p = 0.013). TEAEs occurred in 40.2% of patients, with most being mild in severity. In conclusion, safinamide at a dosage of 100 mg/day significantly improved motor symptoms, QoL, and pain, and demonstrated a favourable safety profile without levodopa dosage escalation during the 18-week treatment period in Korean patients with PD.

Trial registration number and date: NCT05312632, First Posted: April 5, 2022
Renal tubular damage as an independent risk factor for all-cause and cardiovascular mortality in a community-based population: the Takahata study
Authors: Suzuki Takaya , Ichikawa Kazunobu , Suzuki Natsuko , Watanabe Masafumi , Konta Tsuneo 
Published: November 2024

Abstract
Background
Renal tubular damage plays a crucial role in the development of end-stage kidney disease, a risk factor for cardiovascular events and mortality. However, the relationship between renal tubular damage and all-cause and cardiovascular mortality rates in the general population remains unclear. To address this gap, we conducted a cohort study in the general population using the urinary β2-microglobulin-creatinine ratio (UBCR) as a marker of renal tubular damage.

Methods
This study included 3427 residents aged ≥ 40 years in Takahata, Japan. We examined the association between the UBCR values in single-spot urine samples at enrollment and all-cause and cardiovascular mortality rates within a median follow-up of 9.2 years.

Results
The participants were divided into two groups based on their UBCR levels (< 300 μg/g and ≥ 300 μg/g groups). Kaplan–Meier analysis showed a significantly higher incidence of all-cause and cardiovascular mortality rates in the high UBCR group (log-rank P < 0.01). Multivariable Cox proportional hazards model adjusted for age, sex, estimated glomerular filtration rate (eGFR), urine albumin level, smoking, and comorbidities showed a significantly higher hazard ratio of 1.49 (95% confidence interval (CI) 1.10–2.03, P = 0.01) for all-cause mortality and a hazard ratio of 1.73 (95% CI 1.00–2.98, P = 0.048) for cardiovascular mortality in the high-UBCR group. The net reclassification index was significantly improved by adding a high UBCR to the conventional risk factors.

Conclusion
UBCR is an independent risk factor for all-cause and cardiovascular mortality in the general population, independent of eGFR and urinary albumin levels.
A novel bootstrap goodness-of-fit test for normal linear regression models
Authors: Koeneman Scott H. , Cavanaugh Joseph E. 
Published: November 2024

AbstractIn this work, the distributional properties of the goodness-of-fit term in likelihood-based information criteria are explored. These properties are then leveraged to construct a novel goodness-of-fit test for normal linear regression models that relies on a nonparametric bootstrap. Several simulation studies are performed to investigate the properties and efficacy of the developed procedure, with these studies demonstrating that the bootstrap test offers distinct advantages as compared to other methods of assessing the goodness-of-fit of a normal linear regression model. Our inferential technique can be employed using the R package, available freely via the Comprehensive R Archive Network.