bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Residual Evaluation Function Based Fault Diagnosis for a Kind of Nonlinear Systems
Authors: Liu Hai , Zhong Maiying , Liu Yang 
Published: April 2018

AbstractIn this paper, a new residual evaluation function (EF) is proposed for theHi/H∞fault detection filter (FDF). Residuals are projected into the direction of fault, then energy of this projection is adopted as the new EF. Compared with the traditional EF, improvement in FD ability of the new EF is demonstrated rigorously, and a recursive way to calculate it is also proposed under the assumption that fault is slowly time varying. Furthermore, application of this new EF for fault isolation (FI) is discussed, which finally leads to a systematic FDI scheme for a kind of nonlinear systems. Simulations with a nonlinear unmanned aerial vehicle (UAV) model validate the proposed method.
Meta-analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer
Authors: Versteijne E , Vogel J A , Besselink M G , Busch O R C , Wilmink J W , Daams J G , van Eijck C H J , Groot Koerkamp B , Rasch C R N , van Tienhoven G 
Published: April 2018

Abstract

Background
Studies comparing upfront surgery with neoadjuvant treatment in pancreatic cancer may report only patients who underwent resection and so survival will be skewed. The aim of this study was to report survival by intention to treat in a comparison of upfront surgery versus neoadjuvant treatment in resectable or borderline resectable pancreatic cancer.

Methods
MEDLINE, Embase and the Cochrane Library were searched for studies reporting median overall survival by intention to treat in patients with resectable or borderline resectable pancreatic cancer treated with or without neoadjuvant treatment. Secondary outcomes included overall and R0 resection rate, pathological lymph node rate, reasons for unresectability and toxicity of neoadjuvant treatment.

Results
In total, 38 studies were included with 3484 patients, of whom 1738 (49·9 per cent) had neoadjuvant treatment. The weighted median overall survival by intention to treat was 18·8 months for neoadjuvant treatment and 14·8 months for upfront surgery; the difference was larger among patients whose tumours were resected (26·1 versus 15·0 months respectively). The overall resection rate was lower with neoadjuvant treatment than with upfront surgery (66·0 versus 81·3 per cent; P &lt; 0·001), but the R0 rate was higher (86·8 (95 per cent c.i. 84·6 to 88·7) versus 66·9 (64·2 to 69·6) per cent; P &lt; 0·001). Reported by intention to treat, the R0 rates were 58·0 and 54·9 per cent respectively (P = 0·088). The pathological lymph node rate was 43·8 per cent after neoadjuvant therapy and 64·8 per cent in the upfront surgery group (P &lt; 0·001). Toxicity of at least grade III was reported in up to 64 per cent of the patients.

Conclusion
Neoadjuvant treatment appears to improve overall survival by intention to treat, despite lower overall resection rates for resectable or borderline resectable pancreatic cancer.
PROSPERO registration number: CRD42016049374.
Improved Capacity Retention of Metal Oxide Anodes in Li‐Ion Batteries: Increasing Intraparticle Electronic Conductivity through Na Inclusion in Mn3O4
Authors: Palmieri Alessandro , Yazdani Sajad , Kashfi‐Sadabad Raana , Karakalos Stavros G. , Ng Benjamin , Oliveira Alexandra , Peng Xiong , Pettes Michael T. , Mustain William E. 
Published: April 2018

AbstractIn this work, we significantly improve the cyclability of Mn3O4 anodes in Li‐ion batteries by enhancing its intraparticle electronic conductivity by doping with Na. Na was selected because, unlike typical transition‐metal dopants, it is non‐surface redox active in the potential window where the metal oxide conversion reaction occurs, and hence is more electrochemically stable during charge/discharge cycling. This work presents the first time that Na has been used as a dopant in metal oxide anodes, and the result is excellent capacity retention and rate capability. More specifically, Na was added to Mn3O4 (to achieve a Mn/Na ratio of ca. 9 : 1), impregnated onto a carbon nanotube matrix. The concentration of Na considering the entire composition of the anode material was 0.5 at %. These electrodes were able to achieve a capacity of approximately 750 mAh/g at a 1C rate, and retain over 99 % of that capacity over 500 cycles. They were also able to provide nearly twice the theoretical capacity of conventional graphite anodes under high rate discharge (609 mAh/g @ 5C), as well as achieve a higher capacity at 10C (ca. 350 mAh/g) than conventional graphite electrodes can at 1C.
The relative importance of employee green behavior for overall job performance ratings: A policy‐capturing study
Authors: Bohlmann Clarissa , van den Bosch Jeroen , Zacher Hannes 
Published: April 2018

AbstractOrganizational researchers and practitioners are increasingly interested in the topic of employee pro‐environmental or ‘green’ behavior. In this study, we examine the relative importance of employee green behavior to overall job performance ratings compared with task performance, organizational citizenship behavior and counterproductive work behavior. We used an experimental policy‐capturing design, which involves participants rating the job performance of several hypothetical employees who vary in their work behaviors. Thirty‐eight managers from the Netherlands each rated 36 scenarios describing employee behaviors (1368 ratings in total). Results showed that employees' task performance contributed most to overall job performance ratings, followed by counterproductive work behavior, organizational citizenship behavior and employee green behavior. More broadly, findings suggest that employee green behavior makes an independent positive contribution to overall job performance ratings, but its influence is weaker than that of other forms of work behavior. Implications for future research and green human resource management are discussed.
Secure sharing of mobile personal healthcare records using certificateless proxy re‐encryption in cloud
Authors: Bhatia Tarunpreet , Verma A. K. , Sharma Gaurav 
Published: April 2018

AbstractThe ubiquitous and timely access to personal health records help physicians to take critical decisions and save lives. Cloud computing has a potential to provide ubiquitous and on‐demand instant access to common pool of shared resources and services to various stakeholders involved in electronic healthcare industry such as patients, healthcare professionals, insurance companies, etc. The speedy evolution and adoption of cloud computing in electronic healthcare systems have inevitably raised concerns enveloping outsourced data in a myriad of safety issues. In this paper, cryptanalysis of Qin's scheme is performed breaching confidentiality of their scheme. We further proposed a lightweight and pairing free single‐hop unidirectional certificateless proxy re‐encryption scheme based on elliptic curves for secure sharing of mobile personal health records with public cloud competent for low‐power mobile devices. In certificateless proxy re‐encryption, patients encrypt the data with their public keys before outsourcing to the cloud and cloud resident semitrusted proxy further re‐encrypts into ciphertext under intended recipient's public key without learning anything about encrypted message. We prove its security through formal analysis against chosen ciphertext attack in the random oracle model. Our proposed scheme is more efficient and suitable for low‐power mobile devices in comparison with existing schemes.
A novel strategy and kinetics analysis of half‐fractional high cell density fed‐batch cultivation of Zygosaccharomyces rouxii
Authors: Li Zhijiang , Zhou Yanan , Yang Hongzhi , Zhang Dongjie , Wang Chengtao , Liu Hong , Li Xin , Zhao Jing , Wei Chunhong 
Published: April 2018

AbstractZygosaccharomyces rouxii is an important microorganism for aroma production in traditional fermented foods. Using Z. rouxii as the original strain, the batch was split after glucose depletion in the culture medium. Half of the volume of the culture medium was released, and fresh culture medium was fed in. The exponential culture kinetics and the formula for the half‐fractional fed‐batch cultivations were determined to achieve a new strategy for high cell density culturing of Z. rouxii. Based on a full cultivation, three half‐fractional fed‐batch cultivations were performed after every 10 hr of culture. The specific growth rates of Z. rouxii at the different stages were in the order μX0>μX1>μX2>μX3 (0.525 to 0.229 hr−1). The glucose substrate consumption rates gradually decreased following the order μS0>μS1>μS2>μS3 (−1.165 to −0.722, g/g). The equation models for cell growth and glucose substrate consumption showed typical exponential behavior. The total cell yield was 1.78‐fold higher than the yield from a full cultivation, and this continuous subculture strategy also indicated a higher efficiency than traditional full cultivation. A new strategy for highly efficient culturing of Z. rouxii was achieved in a pilot scale. A foundation with data support for the production and application of Z. rouxii was developed.
Institutional Reform in the Irrigation Sector in China
Authors: Li Yuanhua 
Published: April 2018

AbstractIrrigation development relies on sustainable water use and sound irrigation facilities. Participatory irrigation management (PIM) is advantageous because it increases irrigation water efficiency, strengthens construction and maintenance of irrigation facilities, improves irrigation service and capacity building, and increases the sense of responsibility for farmers to protect irrigation systems and their sense of being in charge of improving their own irrigation management. However, there remain some issues that have not yet been addressed in practice. This paper summarizes the experiences and lessons from the practice of institutional reform in the irrigation sector in China and discusses the incentives for farmers to participate in irrigation management and the requirements for a well‐functioning water users' association (WUA). Copyright © 2018 John Wiley & Sons, Ltd.
Upregulated lncRNA ADAMTS9‐AS2 suppresses progression of lung cancer through inhibition of miR‐223‐3p and promotion of TGFBR3
Authors: Liu Chao , Yang Zuozhang , Deng Zhiyong , Zhou Youjun , Gong Quan , Zhao Ruilian , Chen Ting 
Published: April 2018

AbstractIn this study, we aimed at investigating effects of lncRNA ADAMTS9‐AS2 on lung cancer progression through regulating miR‐223‐3p and TGFBR3 expressions. Expressions of ADAMTS9‐AS2 in lung cancer tissues and cell lines were determined by reverse transcriptase polymerase chain reaction (qRT‐PCR). TargetScan and miRcode were used to predict the targeting relationships, respectively. The luciferase reporter system was used to verify that the relationship among ADAMTS9‐AS2, TGFBR3 and miR‐223‐3p. Western blot assay tested the protein level changes in TGFBR3. Cell proliferation was determined by CCK‐8 assay. Cell cycle and cell apoptosis were detected by flow cytometry assay, and migration and invasion were determined by transwell assay. Tumor xenograft model was developed to study the influence of ADAMTS9‐AS2 on tumor growth in vivo. qRT‐PCR results demonstrated that lncADAMTS9‐AS2 was lowly expressed in lung cancer tissues. High expression of ADAMTS9‐AS2 in lung cancer cells significantly reduced proliferation ability and inhibited migration, as well as elevating their apoptosis rate. In vivo assay found that ADAMTS9‐AS2 suppressed the lung tumor growth. Bioinformatics predicted that miR‐223‐3p bound directly to the ADAMTS9‐AS2 and TGFBR3, which was later confirmed by luciferase reporter system. ADAMTS9‐AS2 transfection increased TGFBR3 mRNA and protein expressions in lung cancer cells, but miR‐223‐3p transfection significantly decreased them. Besides, our results showed that miR‐223‐3p induced cellular apoptosis while TGFBR3 group showed the complete opposite effect. It was proved that ADAMTS9‐AS2 and TGFBR3 were the direct genes of miR‐223‐3p. MiR‐223‐3p promotes proliferation, migration and invasion of lung cancer cells by targeting TGFBR3. Therefore, ADAMTS9‐AS2, miR‐223‐3p and TGFBR3 may provide potential targets for the treatment of lung cancer patients. © 2018 IUBMB Life, 70(6):536–546, 2018
Telomerase reverse transcriptase suppression inhibits cell proliferation and promotes cell apoptosis in hepatocellular cancer
Authors: Shen Yanfeng , Xi Feng , Li Haibin , Luo Yin , Chen Cheng , Wang Lei 
Published: April 2018

AbstractWe aimed to investigate the role of telomerase reverse transcriptase (TERT) in hepatocellular cancer (HCC) cells. R software was used for differential expressed gene analysis. Western blot and quantitative real time polymerase chain reaction (qRT‐PCR), respectively, were used to detect protein expression and mRNA level of TERT in tumor cell lines. Real‐time quantitative telomeric repeat amplification protocol assay, MTT assay, colony formation assay, and flow cytometry (FCM) assay were used to analyze the telomerase activity, viability, proliferation, cell cycle progression and apoptosis of HCC cells. The proliferation ratio of HCC cells transfected with TERT‐siRNA was significantly decreased compared with control group. Plate clone results suggested that the number of colonies also decreased in TERT‐siRNA group. FCM results showed that more cells were arrested in G0/G1 phase and apoptosis rate increased in TERT‐siRNA group compared with control group. TERT suppression inhibited cell proliferation but promoted cell cycle arrest and cell apoptosis. © 2018 IUBMB Life, 70(7):642–648, 2018
Hybrid minimally invasive technique with the bidirectional rotational Evolution® mechanical sheath for transvenous lead extraction: A collaboration between electrophysiologists and cardiac surgeons
Authors: Migliore Federico , Cavalli Giacomo , Bottio Tomaso , Testolina Martina , De Lazzari Manuel , Bertaglia Emanuele , Iliceto Sabino , Gerosa Gino 
Published: April 2018

AbstractWe report a case of a 63‐year‐old man referred for lead extraction with the bidirectional rotational Evolution® RL mechanical sheath because of systemic infection. As it was judged a “high‐risk” procedure, we opted for a “hybrid,” minimally invasive approach consisting in a minithoracotomic access. This technique is a feasible approach, and it might be a potential safer alternative in the most challenging transvenous lead extraction procedures.
High‐resolution 3D mapping of epicardial conduction during Marshall bundle‐related atrial tachycardia
Authors: Hojo Rintaro , Fukamizu Seiji , Miyazawa Satoshi , Kawamura Iwanari 
Published: April 2018

AbstractA 73‐year‐old woman was admitted for atrial tachycardia (AT) ablation. The activation map and pacing study indicated that the AT propagated around the left pulmonary vein and that the Marshall bundle (MB) bypassed the scar area of the left pulmonary vein ridge and mitral isthmus. The Rhythmia Mapping System revealed double potentials propagated along the assumed position of the MB. The mapping system includes a confidence mask that can be used to visually identify low‐confidence areas of the map based upon extremely low‐voltage signals. Given the low‐voltage area in the endocardial side, the epicardial conduction was emphasized.
A simple method for combining binomial counts or proportions with hazard ratios for evidence synthesis of time‐to‐event data
Authors: Watkins Claire , Bennett Iain 
Published: April 2018

In studies with time‐to‐event data, outcomes may be reported as hazard ratios (HR) or binomial counts/proportions at a specific time point. If the intent is to synthesise evidence by performing a meta‐analysis or network meta‐analysis (NMA) using the HR as the measure of treatment effect, studies that only report binomial data cannot be included in the network.Methods for converting binomial data to HRs were investigated, so that studies reporting binomial data only could be included in a network of HR data. Estimating the log HR is relatively straightforward under the assumptions of proportional hazards and minimal censoring at the binomial data time point. Estimating the standard error of the log HR is harder, but a simple method based on using a Taylor series expansion to approximate the variance is proposed. Thus, we have 2 easy‐to‐calculate equations for the log HR and variance.The performance of the method was assessed using simulations and data from a NMA of multiple sclerosis treatments. In the simulation, our binomial method produced very similar HRs to those from survival analysis when censoring rates were low, and also when censoring rates were high but the event rate was low. In all situations, it outperformed using relative risk to approximate the HR. In the NMA, results were consistent between reported HRs and HRs derived from binomial data for studies that reported both types of data.This method may be useful for easily incorporating trials reporting binomial data into an evidence synthesis of HR data, under certain assumptions.
Impact of CO2 on the elemental composition of the particulate and dissolved organic matter of marine diatoms emerged after nitrate depletion
Authors: Sugie Koji , Yoshimura Takeshi , Wakita Masahide 
Published: April 2018

AbstractAlthough the dissolved inorganic carbon concentration, pH, and nutrient regimes of seawater dramatically change in coastal regions, the synergistic effects of changes in the CO2 and nutrient levels on the elemental dynamics of the particulate and dissolved organic matters (DOMs) produced by diatoms are rarely investigated. Here, we investigated the impacts of four different CO2 levels (180, 380, 600, and 1000 μatm partial pressure of CO2 : pCO2) on the allocation of carbon, nitrogen, phosphorus, and silicon between the particulate matter (PM) and DOM in two cosmopolitan coastal diatoms, Chaetoceros affinis and Ditylum brightwellii, under nutrient‐replete and nitrate‐depleted conditions. Under nutrient‐replete conditions, the specific growth rates of both species were positively correlated with pCO2 levels. The elemental compositions of the exponentially growing diatoms were stable under the different pCO2 conditions. After nitrate depletion, the particulate organic carbon to particulate nitrogen ratio and biogenic silica content per unit biomass in both species were positively correlated with the pCO2 value. Factors affecting the pCO2 dependent change in elemental composition were the variations in the partitioning of organic carbon between PM and DOM in C. affinis, and the physiological uncoupling of intracellular carbon and nitrogen and the intracellular silicon and nitrogen, as well as resting spore formation in D. brightwellii. Under high‐CO2 conditions, the faster growth rates of both diatom species could lead to their dominance in a phytoplankton community; their blooms could modify the first‐order processes in the biogeochemical cycling of bioelements after nitrate depletion.
Precision Sulfonic Acid Polyolefins via Heterogenous to Homogenous Deprotection
Authors: Gaines Taylor W. , Bell Michael H. , Trigg Edward B. , Winey Karen I. , Wagener Kenneth B. 
Published: April 2018

AbstractPolyolefins containing precisely spaced sulfonic acid functionality are made. First, precision ethyl sulfonate ester diene monomers are synthesized, which then are converted to acyclic diene metathesis polymers using Grubbs' catalysis. Subsequently, the poly(ethyl sulfonate esters) are deprotected post‐polymerization via two successful routes, both using a concept of “heterogenous to homogenous deprotection.” The resulting poly(sodium sulfonate) salts are then converted to precise poly(sulfonic acids), where the sulfonic acid functionality is placed either at every ninth or 21st carbon. For comparison, random versions of poly(sulfonates), their salts, and sulfonic acid polymers are synthesized via copolymerization of the “9” sulfonate monomer with 1,9‐decadiene. Precision placement of sulfonic acid functionality could lead to materials of potential utility.
Proteolysis to Identify Protease Substrates: Cleave to Decipher
Authors: Bhagwat Sonali R. , Hajela Krishnan , Kumar Amit 
Published: April 2018

AbstractProteolysis is an irreversible post‐translational modification process, characterized by highly precise yet stable cleavage of proteins. Downstream events in signaling processes are reliant on proteolysis triggered by the protease activity. Studies indicate that abnormal proteolytic activity may lead to the manifestation of diseased conditions. Therefore, characterization of proteases may provide clues to understand their role in fundamental cellular processes like cellular growth, differentiation, apoptosis, and survival. The relevance of proteases and their substrates as clinical targets are being studied. Understanding the mechanism of proteolytic activity, the identity, and the role of repertoire of its substrates in a physiological pathway has opened avenues for novel drug designing. However, only a limited knowledge of protease substrates is currently available. In this review, the authors recapitulate the library screening, proteomics, and bioinformatics based approaches that have been employed for the identification of protease substrates.
Shock Wave and Detonation Properties of Pressed Hydrazine Nitrate
Authors: Utkin Alexander V. , Mochalova Valentina M. 
Published: April 2018

AbstractIn this work, the structure of the steady‐state detonation waves, the critical diameter, detonation parameters and the dependence of detonation velocity on the charge diameter for pressed hydrazine nitrate (HN) charges in the density range of 1.40–1.68 g/cm3 were investigated by VISAR interferometer. It was found that the critical diameter drops with the initial density decrease. Under steady‐state detonation conditions at a maximum initial density of 1.68 g/cm3, a high detonation velocity of 8.92 km/s is realized in HN charges. The change of the detonation velocity with variation of the initial density is not monotonic, but has a characteristic s‐shape. Experiments on the determination of Hugoniot data and initiation of detonation under shock wave action for HN were carried out with samples of maximum density. The results of the conducted experiments show the low shock wave sensitivity, which is much lower than that of TNT. A noticeable reaction rate behind the front of the initiating shock wave in charges of maximum density is observed only at a pressure above 20 GPa.