bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent initiatives in harmonization of hemostasis practice
Authors: Favaloro Emmanuel J. , Gosselin Robert , Olson John , Jennings Ian , Lippi Giuseppe 
Published: May 2018

Abstract
Accepting that standardizing and harmonizing laboratory practice has considerable value within laboratory medicine, including within the field of hemostasis, this paper concentrates on some recent and important initiatives in harmonizing hemostasis practice. Harmonization of hemostasis practice to improve clinical diagnosis and management is best driven by evidence and, in the absence of evidence, by consensus and expert opinion. To such end, there are various groups involved in such initiatives, and recent initiatives by these groups are highlighted in this review.
Which cytochrome P450 metabolizes phenazepam? Step by step in silico, in vitro, and in vivo studies
Authors: Ivashchenko Dmitriy V. , Rudik Anastasia V. , Poloznikov Andrey A. , Nikulin Sergey V. , Smirnov Valeriy V. , Tonevitsky Alexander G. , Bryun Eugeniy A. , Sychev Dmitriy A. 
Published: May 2018

Abstract

Background:
Phenazepam (bromdihydrochlorphenylbenzodiazepine) is the original Russian benzodiazepine tranquilizer belonging to 1,4-benzodiazepines. There is still limited knowledge about phenazepam’s metabolic liver pathways and other pharmacokinetic features.

Methods:
To determine phenazepam’s metabolic pathways, the study was divided into three stages: in silico modeling, in vitro experiment (cell culture study), and in vivo confirmation. In silico modeling was performed on the specialized software PASS and GUSAR to evaluate phenazepam molecule affinity to different cytochromes. The in vitro study was performed using a hepatocytes’ cell culture, cultivated in a microbioreactor to produce cytochrome P450 isoenzymes. The culture medium contained specific cytochrome P450 isoforms inhibitors and substrates (for CYP2C9, CYP3A4, CYP2C19, and CYP2B6) to determine the cytochrome that was responsible for phenazepam’s metabolism. We also measured CYP3A activity using the 6-betahydroxycortisol/cortisol ratio in patients.

Results:
According to in silico and in vitro analysis results, the most probable metabolizer of phenazepam is CYP3A4. By the in vivo study results, CYP3A activity decreased sufficiently (from 3.8 [95% CI: 2.94–4.65] to 2.79 [95% CI: 2.02–3.55], p=0.017) between the start and finish of treatment in patients who were prescribed just phenazepam.

Conclusions:
Experimental in silico and in vivo studies confirmed that the original Russian benzodiazepine phenazepam was the substrate of CYP3A4 isoenzyme.
Reducing formaldehyde emission from wood-based panels by modification of UF and MUF resins with condensates obtained from kiln-drying of wood
Authors: Ayrilmis Nadir , Kaptı Tolga , Gürel Ali , Ohlmeyer Martin 
Published: May 2018

Abstract
Liquid condensates collected during drying of lumber, sawdust or wood powder are usually discarded. The objective of this study was to investigate the potential utilization of such condensates from oak, beech and walnut, focusing on those obtained in a 7.8 MHz vacuum dryer. The condensate was replaced with the deionized water (5%) in the production of urea-formaldehyde (UF) and melamine-urea-formaldehyde (MUF) resins in the reactor. The technical properties of the resins and chemical properties of the liquid condensates were determined. Particleboards (PB) and middle density fiberboards (MDF) were produced from the control and modified resins. The technical properties of both modified resins were between the limit values of commercial UF and MUF resins used in the wood-based panel industry. The formaldehyde (F) emission from PB and MDF decreased significantly by incorporation of the condensates into the UF and MUF resins.
A pilot study exploring the impact of cardiac medications on ciliary beat frequency: possible implications for clinical management
Authors: Loomba Rohit S. , Bhushan Abhinav , Afolayan Adeleye J. 
Published: May 2018

Abstract

Background
Cilia are involved in several physiologic processes, and at least a single primary cilium can be found on nearly every cell in the human body. Various factors, such as pH, temperature, exposure to medications and toxins can impact ciliary function as is manifested by changes in the ciliary beat frequency. Those with ciliary dyskinesia may also have congenital cardiac malformations and may require care in a cardiac intensive care unit. This study investigates the effect on the ciliary beat frequency of medications frequently used in a cardiac intensive care unit.

Methods
The ciliated epithelial cells were obtained via nasal swab from a relatively healthy individual. These cells were cultured for 24 h. Video microscopy was then employed to determine the ciliary beat frequency at baseline and then at 15, 30, 60 and 90 min after exposure to either normal saline (control) or one of several medications. The ciliary beat frequency at each time point was then compared to the ciliary beat frequency at the same time point in the control sample as well as the baseline value for that particular sample.

Results
Epinephrine increased the ciliary beat frequency compared to the baseline and the controls up to 30 min and then subsequently led to a significant decrease in ciliary beat frequency at 90 min. On the one hand, norepinephrine, dexmedetomidine, procainamide, propranolol and enalapril all decreased ciliary beat frequency significantly throughout the 90-min observation period. On the other hand, Milrinone significantly increased the ciliary beat frequency throughout the observation period, while heparin had no impact on ciliary beat frequency.

Conclusions
The medications frequently used in cardiac intensive care unit impact ciliary function, with most being ciliodepressant. Further investigation is needed to determine the clinical impacts and whether these effects are exaggerated in those with ciliary dyskinesia.
Accuracy estimates of regularization methods and conditional well-posedness of nonlinear optimization problems
Authors: Kokurin Mikhail Y. 
Published: May 2018

Abstract
We investigate the nonlinear minimization problem on a convex closed set in a Hilbert space. It is shown that the uniform conditional well-posedness of a class of problems with weakly lower semicontinuous functionals is the necessary and sufficient condition for existence of regularization procedures with accuracy estimates uniform on this class. We also establish a necessary and sufficient condition for the existence of regularizing operators which do not use information on the error level in input data. Similar results were previously known for regularization procedures of solving ill-posed inverse problems.
The use of the Rotterdam Transition Profile: 10 years in review
Authors: Zhang-Jiang Sofía , Gorter Jan Willem 
Published: May 2018

AbstractThe aim of this literature review was to describe the use and utility of the Rotterdam Transition Profile (RTP), as we near the tenth year since its publication in 2008. It is a tool to summarize a youth’s transition process to adulthood by classifying various domains of participation and health care into developmental stages. This review provided a comprehensive synthesis of available knowledge on the RTP by summarizing published and grey literature. Using search terms related to transition, social participation, and questionnaire, a systematic search was conducted for literature up to November 2017 in MEDLINE and Embase databases, and was supplemented with a hand-search using Google Scholar and a general internet search using Google Search. Inclusion criteria were specified to determine the papers selected for review, yielding fifty-five materials for detailed review. Combined analysis of published and grey literature identified nine papers that used some form of the RTP as a measure, 18 materials that cited the RTP or its domains but did not employ it as a measure, and twenty-eight materials that cited the original RTP development and validation paper for information not directly related to the RTP. The literature demonstrated that the RTP seems to be a useful tool to describe and monitor the transition process of adolescents and young adults, in both research and clinical settings. While it has been used with youth of 14–31 years of age across genders and health conditions, more evidence is needed to demonstrate its psychometric properties beyond construct validity in young adults with cerebral palsy.
Optional ergative, agentivity and discourse prominence – Evidence from Yali (Trans-New Guinea)
Authors: Riesberg Sonja 
Published: May 2018

AbstractA phenomenon often termed “optional ergative marking” is found in a number of genetically unrelated languages. Yali, a Trans-New Guinea language spoken in West Papua, shows striking similarities to optional ergative systems as described in the literature. This paper focuses on the relation between agentivity and discourse prominence, and argues in favour of a systematic distinction between semantic and syntactic contexts as conditioning factors for optional ergative marking. It further provides new evidence for the close interplay of ergative marking and what has been termed “discourse prominence” in descriptions of some other languages and shows that in Yali, optional ergative marking operates on both the global and the local level of discourse.
Feeding strategy of two rodent species in a set-aside field and its influence on alimentary tract morphometry
Authors: Heroldova Marta , Janova Eva 
Published: May 2018

Abstract
We examined the feeding strategy of two dominant rodents, the common vole (Microtus arvalis) and the pygmy field mouse (Apodemus uralensis), in set-aside fields over a period of 1 year. Diet analysis revealed dominance of green plant shoots in common vole’s diet and seeds in the diet of the pygmy field mouse. Food availability in the set-aside fields was strongly correlated with the diet of the herbivorous common vole, but not with that of the granivorous pygmy-field mouse. Both feeding strategies reflect specific morphological adaptations of the digestive tract of both species. A comparison of the gastrointestinal tract (GIT; length and mass without oesophagus; including contents) of the common vole and pygmy field mouse revealed a correlation between body size and length and the GIT weight in both species. The common vole had a proportionally heavier GIT with a larger of the common vole and pygmy field mouse relative proportion of caecum. The GIT length was proportionally greater in juvenile females, while the GIT weight was greater in adult females of both species. The GIT morphometry of both species varied with season and reproductive status, presumably as food consumed altered in line with vegetation phenology and the rodent’s energy requirements.
Hong Kong bilingual legislation and plain language drafting: A communicative approach
Authors: Chan Clara Ho-yan 
Published: May 2018

Abstract
This paper proposes law drafting techniques, especially in Chinese, that aim to enhance the fluency and readability of Hong Kong bilingual legislation. The study is based on the plain language guide published by the Department of Justice of Hong Kong in 2012, with the goal of helping the current legislation to comply with the guidelines. Using data from seven recently-enacted ordinances, the analysis illustrates drafting techniques for their English and Chinese versions in accordance with the plain language guide published by the Department of Justice. This process is accomplished by suggesting revisions for relevant Chinese sections of legislation and their corresponding English sections according to contrasting aspects of English and Chinese grammars. The discussion will also evaluate the plain language drafting and the overall theoretical and philosophical trend of law drafting in Hong Kong, in light of the “Seven Standards of Textuality” proposed by de Beaugrande and Dressler. This is believed to be the first undertaking to study plain legal language against its official guidelines in the Hong Kong context.
Anomalous temperature coefficient of resistance in graphene nanowalls/polymer films and applications in infrared photodetectors
Authors: Zhang Hui , Zhao Kangyi , Cui Songya , Yang Jun , Zhou Dahua , Tang Linlong , Shen Jun , Feng Shuanglong , Zhang Weiguo , Fu Yongqi 
Published: May 2018

AbstractGraphene nanowalls (GNWs) exhibit outstanding optoelectronic properties due to their peculiar structure, which makes them a great potential in infrared (IR) detection. Herein, a novel IR detector that is composed of polydimethylsiloxane (PDMS) and designed based on GNWs is demonstrated. Such detector possesses an anomalous temperature coefficient of resistance of 180% K−1 and a relatively high change rate of current (up to 16%) under IR radiation from the human body. It primarily attributes to the ultra-high IR absorption of the GNWs and large coefficient of thermal expansion of PDMS. In addition, the GNW/PDMS device possesses excellent detection performance in the IR region with a responsivity of ~1.15 mA W−1. The calculated detectivity can reach 1.07×108 cm Hz1/2 W−1, which is one or two orders of magnitude larger than that of the traditional carbon-based IR detectors. The significant performance indicates that the GNW/PDMS-based devices reveal a novel design concept and promising applications for the future new-generation IR photodetectors.
The crystal structure of 4-tert-butyl-N′-[(E)-(4-fluoro-3-methoxyphenyl)methylidene]benzohydrazide, C19H21F1N2O2
Authors: Ikram Muhammad , Khan Momin , Ahmad Sajjad , Rehman Sadia , Schulzke Carola 
Published: May 2018

AbstractC19H21F1N2O2, monoclinic,Cc(no. 9),a= 14.337(3) Å,b= 15.549(3) Å,c= 8.0212(16) Å,β= 103.33(3)°,V= 1740.0(6) Å3,Z= 4,Rgt(F) = 0.0796,wRref(F2) = 0.2192, T = 170 K.
Emigdiano Blues: The California Indigenous Pigment Palette and an In Situ Analysis of an Exotic Colour
Authors: Bedford Clare , Robinson David Wayne , Gandy Devlin 
Published: May 2018

AbstractThe Native inhabitants of South Central California produced rock art containing red, orange, black, white, green and blue colours using a range of mineral and organic materials. Many of these same colours were used on material culture and body painting. This paper focuses on a sub-group of the Chumash, called the Emigdiano, who produced an enigmatic blue colour used in the creation of rock art. Here, we focus on the blue pigment at the rock shelter site of Three Springs in the Wind Wolves Preserve in South Central California. The composition of blue pigments has previously been the focus of discussion with suggestions that they were produced either using European pigments taken from Spanish missions, or that azurite from a local quarry was the source. Previous experimental work had demonstrated that it was possible for the blue to be produced from locally available azurite. Here we present the in situ analyses of these enigmatic blue pigments using handheld X-ray Fluorescence (pXRF). Results from pXRF analysis of rock art, quarried azurite samples and experimental rock art reconstructions showed that the Emigdiano Blue at Three Springs were not azurite based and was composed of optical blue (a mixture of black and white or grey materials which mimic the appearance of blue). This paper discusses the surprising implications of the use, given the availability of a ‘true’ blue pigment, and the wider ontological importance of combining multiple colours to produce the effect of blue in a rock art panel.
Rab23 and developmental disorders
Authors: Hor Catherine H.H. , Tang Bor Luen , Goh Eyleen L.K. 
Published: May 2018

Abstract
Rab23 is a conserved member of the Rab family of small GTPases that regulates membrane trafficking in eukaryotes. It is unique amongst the Rabs in terms of its implicated role in mammalian development, as originally illustrated by the embryonic lethality and open neural tube phenotype of a spontaneous mouse mutant that carries homozygous mutation of open brain, a gene encoding Rab23. Rab23 was initially identified to act as an antagonist of Sonic hedgehog (Shh) signaling, and has since been implicated in a number of physiological and pathological roles, including oncogenesis. Interestingly, RAB23 null allele homozygosity in humans is not lethal, but instead causes the developmental disorder Carpenter’s syndrome (CS), which is characterized by craniofacial malformations, polysyndactyly, obesity and intellectual disability. CS bears some phenotypic resemblance to a spectrum of hereditary defects associated with the primary cilium, or the ciliopathies. Recent findings have in fact implicated Rab23 in protein traffic to the primary cilium, thus linking it with the primary cellular locale of Shh signaling. Rab23 also has Shh and cilia-independent functions. It is known to mediate the expression of Nodal at the mouse left lateral plate mesoderm and Kupffer’s vesicle, the zebrafish equivalent of the mouse node. It is thus important for the left-right patterning of vertebrate embryos. In this review, we discuss the developmental disorders associated with Rab23 and attempt to relate its cellular activities to its roles in development.
Jet Engines – The New Masters of Advanced Flight Control
Authors: Gal-Or Benjamin 
Published: May 2018

Abstract
ANTICIPATED UNITED STATES CONGRESS ACT should lead to reversing a neglected duty to the people by supporting FAA induced bill to civilize classified military air combat technology to maximize flight safety of airliners and cargo jet transports, in addition to FAA certifying pilots to master Jet-Engine Steering (“JES”) as automatic or pilot recovery when Traditional Aerodynamic-only Flight Control (“TAFC”) fails to prevent a crash and other related damages [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42]. Replacement of propeller driven air vehicles with jet engines marks the first jet-engine historical revolution. Yet designers of TAFC still a priori arrest jet engines to provide only brute force forward – a practice leading to wrong freezing of wings, tails, canards, landing gear, airframe and avionics prior to selection of off-the-shelf jet engine to fit that non-integrated design. A second jet-engine revolution is currently in. It originated by failures of TAFC to function and prevent catastrophes especially in post-stall flight domains, takeoff and landing, which mark the JES-Revolution. Full scale JES implementation started in 1986 in the U.S. by YF-22 design [24, 31, 32, 33, 34]. Three years later the YF-22 prototype was selected over the YF-23 that lacked IPA-78402 JES Technologies [31] like 60+ to 1 kill-ratio advantage during WVR air combat – a revolution gradually followed by RUSSIA, CHINA, INDIA, JAPAN and South KOREA [20, 21, 28]. Civilizing JES to maximize future passengers flight safety by preventing various airlines catastrophes [8] had been successfully first flight tested by a subscale JES-Boeing-727 under U.S. FAA support [8, 25]. Pro and cons of military vs. civil JES-technologies are presented by this editorial.
Die deutsche Krankenhauspolitik: Eine Geschichte verpasster Strukturreformen?
Authors: Dittmann Heidi 
Published: May 2018

Abstract:The introduction of the DRG system in 2003/04 can be considered the last real hospital reform. Although the latest reform was called Hospital Structure Act due to its insufficient structural components it is sometimes referred to as missed reform. Essential aspects of the institutional background remained unchanged. However, a closer look reveals even the introduction of the DRG system was only a change in the reimbursement of operating costs. Further structural changes were neither discussed nor induced. The same applies to all subsequent reforms. The key parameters of the regulatory framework are for the greater part the same as those established by the German Hospital Finance Act in 1972. Against this backdrop, the presented paper discusses the institutional background and potential reasons for its continuance. The focus is on the question, whether missed reforms are based on its optimality or which alternative explanations seem to be convincing.
Geldpolitischer Aktionismus, Ersparnisbildung und Kapitalallokation – Einige ökonomische Überlegungen
Authors: Prinz Aloys , Beck Hanno 
Published: May 2018

Zusammenfassung:In diesem Beitrag wird untersucht, wie private Haushalte auf Niedrig- bzw. Nullzinsen reagieren. Dabei wird angenommen, dass die Haushalte sich an Nominalwerten orientieren. Die stark expansive Geldpolitik mit sehr geringen Zinsen verzerren die Ersparnisbildung und die Risikoallokation privater Portfolios. Dies senkt das Nutzenniveau der Sparer-Haushalte. Darüber hinaus sind die Haushalte doppelt negativ von der Geldpolitik betroffen, da die Anlageerträge nicht nur geringer, sondern auch riskanter geworden sind. Des Weiteren kann eine Niedrig- bzw. Nullzinspolitik Vermögensmarkteffekte auslösen, wenn sie Anlagemittel auf bestehende Vermögensgüter umleitet. Deren Preise können dadurch inflatorisch erhöht werden, was letztlich zu Vermögenspreisblasen führen kann. Alles zusammengenommen ist kaum auszuschließen, dass diese Effekte auch makroökonomisch negative Folgewirkungen nach sich ziehen.
Intermolecular interactions in crystals of small unsubstituted cyclic ethers and substituted epoxides
Authors: Spackman Mark A. 
Published: May 2018

Abstract
CE-B3LYP model energies are used to investigate intermolecular interactions in crystals of the relatively weakly bound cyclic ethers, as well as a number of substituted epoxides that have been the focus of high-quality experimental electron density studies. This approach readily provides a complete picture of all intermolecular interactions in these molecular crystals, and CE-B3LYP lattice energies for the unsubstituted cyclic ethers are in excellent agreement with available thermodynamic data. When compared with the outcomes of multipole modelling of X-ray diffraction data, these results suggest that experimental interaction energies are typically underestimated and, contrarily, experimental lattice energies are typically overestimated. These observations deserve careful investigation.
A Novel Class of Chaotic Flows with Infinite Equilibriums and Their Application in Chaos-Based Communication Design Using DCSK
Authors: Rajagopal Karthikeyan , Çiçek Serdar , Khalaf Abdul Jalil M. , Pham Viet-Thanh , Jafari Sajad , Karthikeyan Anitha , Duraisamy Prakash 
Published: May 2018

Abstract
Discovering chaotic systems with interesting features has been of interest in the recent years. One such important and interesting feature is the type and shape of equilibrium points. We introduce a class of chaotic systems which could show different types of infinite equilibrium points. The fundamental properties of the proposed systems like bifurcation diagram and Lyapunov exponents are investigated. An electronic circuit of the presented chaotic systems is implemented. In addition, a chaos-based communication application by the differential chaos shift keying method with the new chaotic system is designed and tested for engineering application. According to the design test results, the proposed chaos-based communication system is successful. Therefore, the new chaotic system can be used in chaos-based communication systems.