bluuebunny/crossref_metadata_2025_split huggingface dataset:
MOF‐Based Organic Microlasers
Authors: He Huajun , Li Hongjun , Cui Yuanjing , Qian Guodong 
Published: April 2019

AbstractOrganic lasers have become an important research and application target for the development of optoelectronics and future photonics due to their ease of preparation and miniaturization, low threshold, and wideband tunability, as well as large optical and nonlinear optical cross sections. Recently, the metal–organic framework (MOF) based organic microlasers have received increasing research attention because they not only achieve high gain concentrations while minimizing the common aggregation‐caused quenching effect of organic luminescence systems, but also can optimize and even control the output performance of the laser by manipulating the interaction between the framework and the gain molecules. In this review, the latest advances in MOF‐based organic lasers are explored and insights into future trends are given, providing useful guidance for the design and preparation of new‐type lasers.
Modulation‐Based Atom‐Mirror Entanglement and Mechanical Squeezing in an Unresolved‐Sideband Optomechanical System
Authors: Bai Cheng‐Hua , Wang Dong‐Yang , Zhang Shou , Liu Shutian , Wang Hong‐Fu 
Published: April 2019

AbstractA hybrid optomechanical system which is composed of an atomic ensemble and a standard optomechanical cavity driven by a periodically modulated external laser field is investigated. Based on the simple periodic modulation forms of the driving amplitude and effective optomechanical coupling, respectively, the atom‐mirror entanglement is discussed in detail. It is found that the maximum of the entanglement in the unresolved‐sideband regime can be further enhanced compared with the non‐modulation regime. On the other hand, we find that the introduction of the atomic ensemble permits the mechanical squeezing induced by the periodic amplitude modulation can be successfully generated even in the unresolved‐sideband regime. Due to the self‐cooling mechanism constructed by the atomic ensemble, the mechanical squeezing scheme no longer requires the extra precooling technologies.
A Single Atom Change Facilitates the Membrane Transport of Green Fluorescent Proteins in Mammalian Cells
Authors: Jakka Surendar R. , Govindaraj Vijayakumar , Mugesh Govindasamy 
Published: April 2019

AbstractDirect delivery of proteins into mammalian cells is a challenging problem in biological and biomedical applications. The most common strategies for the delivery of proteins into the cells include the use of cell‐penetrating peptides or supercharged proteins. Herein, we show for the first time that a single atom change, hydrogen to halogen, at one of the tyrosine residues can increase the cellular entry of ∼28 kDa green fluorescent protein (GFP) in mammalian cells. The protein uptake is facilitated by a receptor‐mediated endocytosis and the cargo can be released effectively into cytosol by co‐treatment with the endosomolytic peptide ppTG21.
Sauerstoffevolutionselektrokatalyse eines einzelnen MOF‐basierten Kompositnanopartikels an der Spitze einer Nanoelektrode
Authors: Aiyappa Harshitha Barike , Wilde Patrick , Quast Thomas , Masa Justus , Andronescu Corina , Chen Yen‐Ting , Muhler Martin , Fischer Roland A. , Schuhmann Wolfgang 
Published: April 2019

AbstractDie Bestimmung der intrinsischen elektrokatalytischen Aktivität mithilfe von Makroelektroden wird durch Ensemble‐ und Filmeffekte beeinträchtigt. Hier wird ein neuartiger “Partikel‐am‐Stiel”‐Ansatz genutzt, um ein einzelnes Nanopartikel einer metallorganischen Gerüstverbindung (MOF; ZIF‐67) auf der Oberfläche einer Nanoelektrode wachsen zu lassen. Dieses Nanopartikel wird pyrolysiert, um einen mit Stickstoff dotierten Kohlenstoff/Kobalt‐Kompositnanopartikel zu erhalten, das eine sehr hohe katalytische Aktivität für die Sauerstoffevolutionsreaktion (OER) mit einer Stromdichte von bis zu 230 mA cm−2 bei 1.77 V (vs. RHE) und eine hohe Wechselzahl (TOF) von 29.7 s−1 bei 540 mV Überpotential aufweist. Die Analyse mittels positionsidentischer Transmissionselektronenmikroskopie (IL‐TEM) bestätigt die selbstopfernde Natur des MOF, wobei die Analyse nach erfolgter Elektrokatalyse die Agglomeration von Co‐Zentren im Co‐N/C‐Kompositpartikel während der OER belegt. Die elektrochemische Analyse einzelner nanoskaliger Objekte (single‐entity electrochemistry) erlaubt es, die intrinsische elektrokatalytische Aktivität zu ermitteln und bietet Einblicke in strukturelle Veränderungen des Elektrokatalysators unter Reaktionsbedingungen, die industriellen Bedingungen entsprechen.
Intelligent maximum power tracking control of a PMSG wind energy conversion system
Authors: Asri Aicha , Mihoub Youcef , Hassaine Said , Logerais Pierre‐Olivier , Allaoui Tayeb 
Published: April 2019

AbstractA comparative control study for a maximum power tracking strategy of variable speed wind turbine is provided. The system consists of a direct drive permanent magnet synchronous generator (PMSG) and an uncontrolled rectifier followed by a DC/DC switch‐mode step down converter connected to a DC load. The buck converter is used to catch the maximum power from the wind by generating an efficient duty cycle. Distinct Maximum Power Point Tracking (MPPT) algorithms are analyzed and compared: a classical Proportional‐Integral controller (PI) and two based Fuzzy Logic Controllers (FLC), including a conventional Fuzzy‐PI and an Adaptive FLC‐PI. The main aim of the presented study is to develop an advanced control scheme for wind generators to ensure a high level operating of the system and a maximum power extraction from the wind. This is achieved by analyzing the behavior of the system under fluctuating wind conditions employing Matlab Simpower Systems tool. Simulation results confirm that the Adaptive FLC‐PI controller algorithm has better performances in terms of dynamic response and efficiency especially in comparison with the ones of a PI controller under variable wind speed.
Utilization of prickly pear waste for baker's yeast production
Authors: Diboune Naàssa , Nancib Aicha , Nancib Nabil , Aníbal Jaime , Boudrant Joseph 
Published: April 2019

AbstractThe feasibility of baker's yeast production using fruits and peels of Opuntia ficus indica (OFI) as carbohydrate feedstock was investigated. Two response surface methodologies involving central composite face centered design (CCFD) were successfully applied. The effects of four independent variables on baker's yeast production from OFI fruit juice was evaluated using the first CCFD. The best results were obtained with 24 H of inoculum age, 30 °C temperature, 200 rpm of agitation, and 10% inoculum size. At the maximum point, the biomass concentration reached 9.29 g/L. A second CCFD was performed to optimize the sugar extraction from OFI fruit peels. The potential of these latter as a fermentation substrate was determined. From the experimental results, the OFI fruit peel is an appropriate carbon source for the production of baker's yeast. The maximum biomass concentration was 12.51 g/L. Different nitrogen supplements were added to promote the yields of baker's yeast. Corn steep liquor was found to be the best alternative nutrient source of casein hydrolysate and yeast extract for baker's yeast production.
The clinical characteristic and prognostic factors of leptomeningeal metastasis in patients with non‐small‐cell lung cancer‐a retrospective study from one single cancer institute
Authors: Yan Weiwei , Jing Wang , An Ning , Tian Yaru , Guo Dong , Kong Li , Zhu Hui , Yu Jinming 
Published: April 2019

AbstractBackgroundLeptomeningeal metastasis (LM) is a detrimental complication of advanced non‐small‐cell lung cancer (NSCLC), and the optimal therapeutic approach for LM patients is in shortage. This retrospective study aimed to investigate the clinical features and prognostic factors of NSCLC patients with LM.MethodsWe retrospectively reviewed the medical records of NSCLC patients with LM at the Shandong Cancer Hospital and Institute between July 2014 and March 2018. Identified cases had pathology‐proven NSCLC with either positive cerebrospinal fluid cytology or leptomeningeal enhancement by MRI.ResultsOne hundred and thirty‐six NSCLC patients (58 men, 78 women) with LM were enrolled in the retrospective study; median age was 55 years (range, 29‐89 years). Fifty‐one patients harbored EGFR mutations, ALK rearrangement was detected in 6 patients. Treatment for LM consisted of EGFR‐TKIs alone in 11 patients, whole brain radiotherapy (WBRT) alone in 19 patients, Chemotherapy (ChT) alone in 12 patients, EGFR‐TKIs plus WBRT in 30 patients, WBRT plus ChT in 25 patients, and EGFR‐TKIs plus ChT in 24 patients. The median progression‐free survival was 3.9 months (95% confidence interval [CI]: 3.178‐4.622), and the median overall survival (OSLM) was 9.8 months (95% CI:7.5‐12.1). Thirty patients who received WBRT plus EGFR‐TKIs achieved longer survival than those who only received WBRT (median 13.6 vs 8.8 months; P = 0.027), but did not add any survival benefit than those only received EGFR‐TKIs (median 13.6 vs 13.9 months; P = 0.352). A multivariate analysis indicated that KPS ≥ 80 (hazard ratio [HR] = 0.592, 95% CI:0.369‐0.95; P = 0.03) and EGFR‐TKIs (HR = 0.507, 95% CI:0.283‐0.908; P = 0.022) after LM diagnosis were independent favourable predictors of survival, whereas smoking (HR = 1.181, 95% CI:1.009‐3.246; P = 0.047) was an independent predictor of poor survival.ConclusionsOur results suggest that patients with good performance statuses, non‐smoking patients, and the administration of EGFR‐TKIs might improve clinical outcomes in NSCLC patients with LM.
Effect of genetic variants in cell adhesion pathways on the biochemical recurrence in prostate cancer patients with radical prostatectomy
Authors: Yu Chia‐Cheng , Chen Lih‐Chyang , Lin Victor C. , Huang Chao‐Yuan , Cheng Wei‐Chung , Hsieh Ai‐Ru , Chang Ta‐Yuan , Lu Te‐Ling , Lee Cheng‐Hsueh , Huang Shu‐Pin , Bao Bo‐Ying 
Published: April 2019

AbstractThe aberrant expression of cell adhesion molecules is a hallmark of epithelial‐to‐mesenchymal transition, resulting in the transformation of cancer cells to a more aggressive phenotype. This study investigated the association between genetic variants in cell adhesion pathways and the prognosis of patients with prostate cancer following radical prostatectomy (RP). A total of 18 haplotype‐tagging single‐nucleotide polymorphisms (SNPs) in eight cancer‐related adhesion molecules were genotyped in 458 prostate cancer patients, followed by the replication of the top SNPs in an additional set of 185 patients. Log‐rank test and multivariate Cox regression analysis adjusted for covariates were used to evaluate associations with the risk of biochemical recurrence (BCR) after RP. In the discovery set, four SNPs in CDH2 were marginally associated with BCR. Among these, CDH2 rs643555C > T was found to be associated with BCR in the replication set. Patients with rs643555TT genotype had a significantly shorter BCR‐free survival compared with those with CC/CT genotypes in the combined analysis (adjusted hazard ratio 1.78, 95% confidence interval 1.19‐2.67, P = 0.005). Additional analyses revealed that rs643555T was associated with higher expression of CDH2, and upregulated CDH2 was correlated with tumor aggressiveness and shortened BCR‐free survival. In conclusion, rs643555C > T affects CDH2 expression, and thus influences BCR in localized prostate cancer patients treated with RP. CDH2 rs643555 may be a promising biomarker to identify patients at high risk of poor prostate cancer prognosis.
Exploratory study of automated linguistic analysis for progress monitoring and outcome assessment
Authors: Huston Jonathan , Meier Scott , Faith Myles , Reynolds Amy 
Published: April 2019

AbstractObjectiveThe most successful approach to dealing with treatment failure employs progress monitoring and outcome assessment (PMOA) measures that enable clinicians to identify clients who are failing to progress. On the basis of previous research indicating that word use relates to individuals’ psychological characteristics as well as clinical outcomes, we investigated automated linguistic analysis of client speech as an alternative PMOA approach.MethodsWe employed the Linguistic Inquiry and Word Count (LIWC) program to study the language of a subset of 12 clients from the York I Depression Study. Automated analyses examined transcripts of 24 individual psychotherapy sessions, one early in treatment (T1) and one late in treatment (T2), split between six good and six poor outcome cases.ResultsGood outcomes were associated with more positive emotion words and fewer past focus words and negation words at T1. Logistic regression models predicted good versus poor treatment outcome for 70–82% of transcripts. However, analyses failed to support the hypothesis that language use patterns changed from T1 to T2 during the course of therapy.ConclusionsClinicians have been slow to adopt PMOA measures as part of routine practice, partially as a result of additional paperwork and time burdens. Automated analysis of client language provides one alternative method for decreasing client and therapist workload. This study's results, while mixed, provide evidence that additional research should be conducted to investigate the potential for LIWC and other automated measures to provide PMOA data for clinical feedback.
Cuprophilic Interactions in and between Molecular Entities
Authors: Harisomayajula N. V. Satyachand , Makovetskyi Serhii , Tsai Yi‐Chou 
Published: April 2019

AbstractDespite being weak attractive forces, closed‐shell metallophilic interactions play important roles in the Group 11 metal complexes on their diverse structural and physical features. A plethora of experimental and computational studies has thus been dedicated to such weak attractive d10–d10 interactions, particularly aurophilic and argentophilic interactions. Although d10–d10 CuI–CuI forces had been recognized for four decades, cuprophilic interactions are less explored and they are best evidenced by single‐crystal X‐ray crystallographic analysis on CuI complexes and aggregates thereof, by which precise information about the Cu⋅⋅⋅Cu contacts, shorter than the sum of two van der Waals radii (3.92 Å) between the copper centers concerned can be obtained. Based on recently compelling experimental and spectroscopic evidence for intra‐ and intermolecular cuprophilic interactions in copper chemistry, the present Minireview summarizes recent progress in the past three decades in the synthesis and structures of multinuclear homometallic copper complexes, whereby supported and unsupported d10–d10 CuI–CuI interactions are at work.
Visible Light‐Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three‐Component Photoredox Reaction
Authors: Lipp Benjamin , Kammer Lisa Marie , Kücükdisli Murat , Luque Adriana , Kühlborn Jonas , Pusch Stefan , Matulevičiūtė Gita , Schollmeyer Dieter , Šačkus Algirdas , Opatz Till 
Published: April 2019

AbstractSimultaneous sulfonylation/arylation of styrene derivatives is achieved in a photoredox‐catalyzed three‐component reaction using visible light. A broad variety of difunctionalized products is accessible in mostly excellent yields and high diastereoselectivity. The developed reaction is scalable and suitable for the modification of styrene‐functionalized biomolecules. Mechanistic investigations suggest the transformation to be operating through a designed sequence of radical formation and radical combination.
Iodine Clathrated: A Solid‐State Analogue of the Iodine–Starch Complex
Authors: Pan Fangfang , Chen Yingchun , Li Siyu , Jiang Minzhi , Rissanen Kari 
Published: April 2019

AbstractCo‐crystallizing iodine with a simple dicationic salt (1,8‐diammoniumoctane chloride) results in the clathration of the iodine (I2) molecules inside trigonal and hexagonal helical channels of the crystal lattice with 72 wt % overall I2 loading. The I2 inside the bigger trigonal channel forms a I−I⋅⋅⋅I−I⋅⋅⋅I−I halogen‐bonded infinite helical chain, while the I2 in the smaller hexagonal channel is disordered. In both channels the I2 interaction with the channel wall happens through I−I⋅⋅⋅Cl− halogen bonds. The helical channels in the crystal lattice are constructed via the strong charge‐assisted H2N+H⋅⋅⋅Cl− hydrogen bonds between the dications and the chloride anions. The structure shows a marked similarity with the well‐known starch–I2 system, and thus may provide insight for the yet unresolved structure of the I2 in the helical starch channel.
Insekten und Schimmelpilze als Bioressource
Authors: Rühl Martin , Pietzner Verena , Vilcinskas Andreas , Zorn Holger 
Published: April 2019

ZusammenfassungMikroorganismen werden seit Jahrtausenden zur Herstellung von Lebensmitteln genutzt. Mittlerweile sind diese biotechnologischen Verfahren nicht mehr auf die Verwendung einiger Organismen beschränkt. Die Möglichkeit, Enzyme unabhängig von ihrem Wirtsorganismus zu produzieren, erweiterte den Einsatzbereich dieser technischen Hilfsmittel ungemein. Seither werden vermehrt neue Bioressourcen erschlossen, um neuartige Enzyme und Peptide für die Lebensmittelproduktion verfügbar zu machen: Peptidasen aus Getreideschädlingen vermögen Gluten zu hydrolysieren und antimikrobiell wirksame Peptide aus Insekten könnten zur Haltbarmachung von Lebensmitteln eingesetzt werden. Aber wie findet man solche Katalysatoren? Beispiele aus eigenen Arbeiten zeigen es.
Sustainable Continuous Flow Valorization of γ‐Valerolactone with Trioxane to α‐Methylene‐γ‐Valerolactone over Basic Beta Zeolites
Authors: Al‐Naji Majd , Puértolas Begoña , Kumru Baris , Cruz Daniel , Bäumel Marius , Schmidt Bernhard V. K. J. , Tarakina Nadezda V. , Pérez‐Ramírez Javier 
Published: April 2019

AbstractThe need for more sustainable products and processes has led to the use of new methodologies with low carbon footprints. In this work, an efficient tandem process is demonstrated for the liquid‐phase catalytic upgrading of lignocellulosic biomass‐derived γ‐valerolactone (GVL) with trioxane (Tx) to α‐methylene‐γ‐valerolactone (MeGVL) in flow system using Cs‐loaded hierarchical beta zeolites. The introduction of mesopores along with the presence of basic sites of mild strength leads to MeGVL productivity 20 times higher than with the bulk beta zeolite, reaching 0.325 mmol min−1 gcat−1 for the best‐performing catalyst, the highest value reported so far. This catalyst proves stable upon reuse in consecutive cycles, which is ascribed to the partial depletion of the basic sites. The obtained MeGVL is subjected to visible‐light‐induced polymerization, resulting in a final material with similar properties to the widely used poly(methyl) methacrylate.
A forebrain undivided: Unleashing model organisms to solve the mysteries of holoprosencephaly
Authors: Grinblat Yevgenya , Lipinski Robert J. 
Published: April 2019

AbstractEvolutionary conservation and experimental tractability have made animal model systems invaluable tools in our quest to understand human embryogenesis, both normal and abnormal. Standard genetic approaches, particularly useful in understanding monogenic diseases, are no longer sufficient as research attention shifts toward multifactorial outcomes. Here, we examine this progression through the lens of holoprosencephaly (HPE), a common human malformation involving incomplete forebrain division, and a classic example of an etiologically complex outcome. We relate the basic underpinning of HPE pathogenesis to critical cell‐cell interactions and signaling molecules discovered through embryological and genetic approaches in multiple model organisms, and discuss the role of the mouse model in functional examination of HPE‐linked genes. We then outline the most critical remaining gaps to understanding human HPE, including the conundrum of incomplete penetrance/expressivity and the role of gene‐environment interactions. To tackle these challenges, we outline a strategy that leverages new and emerging technologies in multiple model systems to solve the puzzle of HPE.
Pure, shared, and coupling effects of climate change and sea level rise on the future distribution ofSpartina alternifloraalong the Chinese coast
Authors: Gong Haibo , Liu Huiyu , Jiao Fusheng , Lin Zhenshan , Xu Xiaojuan 
Published: April 2019

AbstractAimGlobal change seriously threatens the salt marsh ecosystem, while it remains unclear howS. will respond to climate change and sea level rise. Here, we investigated interactions among variables and identified the impacts of climate change, sea level rise, and their interactions on the distribution ofSpartina alterniflora.LocationNorthern Chinese coast and Southern Chinese coast.TaxonSpartina alternifloraLoisel.MethodsWith global sensitivity analysis, we determined interactions among variables and their relative importance to the distribution ofS. alterniflora. Integrating the Venn's four‐set diagram, we built ecological niche models under current and three future scenarios to identify pure, shared, and coupling effects of climate change and sea level rise on the distribution ofS. alterniflora.ResultsMean diurnal range (Bio02) and Elevation were the two most critical variables controlling the distribution ofS. alternifloraon the Chinese coast, and interactions among variables of the northern coast were much greater than that of the southern coast. Habitats change was mainly caused by pure effects of climate change, except habitats reduction on the southern coast. Pure effects of sea level rise were low, but it can influence habitats change through shared and coupling effects from complex interactions with climate change. Interactions of climate change and sea level rise can drive habitats change, and the changed habitats caused by shared and coupling effects were mainly distributed the areas near the landward side.Main conclusionsOur research suggests paying attention to interactions among variables when calculating the relative importance of explanatory variables. Identifying pure, shared, and coupling effects of climate change and sea level rise for the distribution ofS. alterniflorawill provide scientific references for assessing the risk of similar coastal species.