bluuebunny/crossref_metadata_2025_split huggingface dataset:
State and Trait Anxiety and Diabetes Outcomes in Youth With Type 1 Diabetes
Authors: Rechenberg Kaitlyn , Szalacha Laura , Salloum Alison , Grey Margaret 
Published: July 2019

Purpose The purpose of this exploratory pilot study was to examine the associations of state and trait anxiety with glycemic control, self-management, and diabetes-specific quality of life (QOL) in youth 10 to 16 years of age with type 1 diabetes (T1D). Methods Bivariate Pearson correlations and multiple linear regression modeling were conducted to examine the relationship among anxiety symptoms, hemoglobin A1C (A1C), self-management, QOL, and covariates. Results A sample of 67 adolescents was 50.7% female, and 87.1% were non-Hispanic white, with a mean ± SD age of 13.4 ± 1.85 years and an A1C of 8.3% ± 1.2% (67 mmol/mol). Higher state anxiety was correlated with older age. Better self-management was correlated with lower trait anxiety and lower state anxiety. Higher state and trait anxiety were associated with poorer self-management. Higher state anxiety was associated with higher A1C. Higher trait anxiety was associated with poorer diabetes-specific QOL. Conclusions State and trait anxiety may differentially affect diabetes outcomes. State anxiety may be a modifiable target for physiologic (A1C) and psychosocial (QOL) outcomes in youth with T1D, while trait anxiety may be a modifiable target for psychosocial outcomes (QOL). Anxiety symptoms should be assessed at regular clinic visits. Interventions to improve anxiety symptoms may in turn improve physiologic and psychosocial outcomes.
Aortic root and ascending aorta dimensions in acute aortic dissection
Authors: Koechlin Luca , Macius Evelina , Kaufmann Josefin , Gahl Brigitta , Reuthebuch Oliver , Eckstein Friedrich , Berdajs Denis A 
Published: July 2019

Objectives: Aim of this study was to evaluate ascending aorta and aortic root dimension at acute type A dissection (acute aortic dissection) and to identify demographics elements being allied to the acute event. Methods: In a period between 2009 and 2017, 225 (n = 71, 32% female, mean age = 63 ± 12 years) patients eligible for analysis of ascending aorta and 223 (n = 70, 31% female, mean age = 63 ± 13 years) of aortic root were included in this study. Aortic diameter was assessed in preoperative computed tomography scan. The predissection diameters were modeled from the diameters obtained at diagnosis, assuming 30% augmentation of the diameter at acute event. Results: The mean diameter of the ascending aorta at dissection was 46 ± 8 mm and the modeled diameter was 32.3 ± 5.7 mm. The diameter of the aortic root at dissection was 42 ± 8 mm and modeled diameter was 29.5 ± 5.6 mm. In multivariate analysis, female gender (p = 0.026) and history of cerebrovascular event (p = 0.001) were associated with acute aortic dissection in small aortic root. Patient age (p < 0.001) and history of inguinal hernia (p = 0.001) in ascending aorta <55 mm correlated with acute aortic dissection. Conclusion: Modeling indicates that more than 90% of patients had aortic root and ascending aorta diameter <45 mm. It seems that the aortic diameter expansion over the 55 mm in development of acute aortic dissection is overestimated. Parameters other than aortic size were identified, which may be considered when patients at high risk for dissection were identified.
Effect of resistance of the exercise band on the peak femoral vein velocity during active ankle flexion
Authors: Tsuda Kouji , Takahira Naonobu , Ejiri Motoki , Sakai Kenta , Sakamoto Miki , Akamine Akihiko 
Published: July 2019

Objective To examine the resistance effect of using an exercise band on the lower extremity venous velocity during active ankle flexion. Methods Twenty healthy young adult men performed active ankle flexion every 2 s either with no band or with two exercise bands, marked red and silver in the order of increasing tension. They held the band in its natural length with an elbow in extension and an ankle in maximal dorsiflexion at initiation of each active plantar flexion in each posture. The peak velocity in the right superficial femoral vein was measured in each condition. Results Holm’s multiple comparisons revealed significant increases in the mean (individual 95% confidence intervals) peak velocities (cm/s) with no, red, and silver bands (35.8 (28.9–42.7), 46.5 (38.8–54.3), and 56.9 (47.0–66.8), respectively, in the sitting posture, and 50.7 (39.2–62.3), 60.7 (46.8–74.6), and 69.0 (55.3–82.7), respectively, in the supine posture; all p < 0.01). Conclusion Resistance with the exercise bands efficiently enhanced the femoral venous velocity during active ankle plantar flexion.
Establishment of prognostic scoring models for different etiologies of acute decompensation in hospitalized patients with cirrhosis
Authors: Cai Qun , Zhu Mingyan , Duan Jinnan , Wang Hao , Sheng Jifang 
Published: July 2019

Objective Acute decompensation (AD) in liver cirrhosis has high mortality. We assessed prognostic scoring models and established prediction models for different etiologies of AD. Methods This retrospective analysis included 732 patients hospitalized with acute decompensated cirrhosis without acute-on-chronic liver failure. We performed logistic regression analysis of risk factors for mortality associated with different etiologies, to establish predictive models. Results Patients with different etiologies, scored using different scoring systems and various impact factors, exhibited differences with respect to mortality. MELD, CLIF-C-AD, MELD-Na, and AARC-ACLF scores exhibited adequate predictive ability for mortality. Area under the receiver operating characteristic curve for 28-day mortality for MELD, CLIF-C-AD, MELD-Na, AARC-ACLF, and the newly developed AD scores was 0.663, 0.673, 0.657, 0.662, and 0.773, respectively, in the hepatitis B virus group (HBV-AD score =−5.51 + 0.07*WBC count (109/L) +0.7*AD sum+0.4*AARC-ACLF score); 0.731, 0.737, 0.735, 0.689, and 0.778, respectively, in the alcoholic liver disease group (ALD-AD score =−4.55 +0.08* WBC count (109/L) +1.34* AD sum); and 0.765, 0.767, 0.814, 0.720, and 0.814, respectively, in the Others group (OTHERS-AD score =−2.14 + 1.24*MELD-Na score +4.49*AD sum). Conclusions The newly developed scoring models for short-term mortality were superior to the other scoring systems in predicting prognosis of acute decompensated cirrhosis in hospitalized patients.
A different perspective: Can urine pH be important in the diagnosis of prostate cancer?
Authors: Ceylan Cavit , Doluoglu Omer Gokhan , Yahşi Sedat 
Published: July 2019

Objective: The aim of our study was to investigate emphasis of urinary pH in patients with prostate cancer. Methods: Patients, who underwent 12-core prostate biopsy because of prostate-specific antigen elevation and suspicious digital rectal examination, were retrospectively reviewed. According to pathology, patients with prostate cancer were classified as group 1, and patients with benign prostatic hyperplasia were classified as group 2. Primary endpoint of this study was the urine pH. The age of two groups and urine pH were compared with each other. Student t test and Mann–Whitney U test were used for the intergroup analysis of continuous variables. A cut-off value for urine pH was determined with a receiver operating characteristic curve. p < 0.05 was considered as statistically significant. Results: There were 119 patients in group 1 and 99 patients in group 2. When urine pHs of both groups were compared, group 1 and group 2 were 5.1 ± 0.45 and 5.5 ± 0.79, respectively (p = 0.0001). The cut-off value determined by receiver operating characteristic curve analysis for urine pH was 5.2 (sensitivity: 42%, specificity: 79%, area under the curve: 0.61; 95% CI: [0.53, 0.68]; p = 0.003). Conclusion: Acidic urine pH may be important for predicting prostate cancer according to this study.
YouTube as a Patient-Information Source for Cleft Lip and Palate
Authors: Korkmaz Yasemin Nur , Buyuk Suleyman Kutalmış 
Published: July 2019

Objective: The aim of the present study was to evaluate the content and quality of the popular videos on YouTubeTM about the treatment of cleft lip and palate. Design: Retrospective, YouTubeTM video analysis. Methods: The 3 keywords “cleft lip and palate surgery,” “cleft lip and palate treatment,” and “cleft lip and palate repair” were searched on YouTubeTM. After sorted by view-count, final 50 videos were analyzed for general characteristics, primary purpose, information content, relevance, audiovisual quality, and also viewers’ interaction index, and viewing rate formulas were calculated for each video. Kruskal Wallis and one-way analysis of variance tests were used to compare the video parameters between good, moderate, and poor information content videos. Results: The viewing rate was significantly higher in good content videos ( P = .003). Most of the videos were uploaded by a clinic (32%), a surgeon (20%), or individuals (22%) who shared their own experience. Most of the videos (54.00%) were classified as moderate general information content and 26.00% were rated as poor, and 20.00% were rated as good. Videos generally involved patient information (60.00%), followed by patient parent’s experience (14.00%), and cleft lip and palate surgery (12.00%). The average viewers’ interaction index of all evaluated YouTubeTM videos was 0.36. Conclusions: Although most of the videos were rated as moderate regarding the sufficiency of the information, the results of this study showed that YouTubeTM could still not be considered as a fully reliable source of information for patients on treatment of cleft lip and palate.
Comparison of using Galilei Dual Scheimpflug Analyzer G4 and Barrett formula in predicting low cylinder preoperatively for cataract surgeries
Authors: Ho Yi-Ju , Sun Chi-Chin , Lee Jiahn-Shing , Lin Ken-Kuo , Hou Chiun-Ho 
Published: July 2019

Purpose: To compare corneal astigmatism estimation from Barrett toric calculator, with measurement from Galilei Dual Scheimpflug Analyzer G4 in low corneal cylinder patients. Methods: Preoperative corneal astigmatism was measured using Auto Kerato-Refractometer (AutoKM), IOL Master, and Galilei G4 (combined Placido-dual Scheimpflug analyzer) and was processed by Barrett toric calculator with measurements obtained from Auto Kerato-Refractometer and from IOL Master. A total of 42 eyes undergoing cataract surgery with nontoric intraocular lens implantation were included. Corneal astigmatism was calculated based on manifest refractive astigmatism with implications of surgically induced astigmatism. Errors in predicted residual astigmatism were calculated by the difference between postoperative manifest cylindrical refractive error and preoperative corneal cylinder using vector analysis. Results: Centroid error in predicted residual astigmatism was with-the-rule 0.36 D for AutoKM and 0.48 D for IOL Master, was lower at 0.24 D for the Barrett–IOL Master, and was lowest at 0.21 D for the Barrett–AutoKM ( p < .001). The Galilei G4 demonstrated the highest centroid error for SimK (0.53 D) and lower for total corneal power (0.49 D). The Barrett toric calculator obtained the lowest median absolute error in predicted residual astigmatism for AutoKM (0.43 D) and IOL Master (0.54 D). The Barrett–IOL Master demonstrated that 61% and 76% of eyes were within 0.50 and 0.75 D of the predicted residual astigmatism, respectively. Conclusion: The Barrett–IOL Master had more accurate prediction of residual astigmatism for low astigmatism eyes before cataract surgery compared to Galilei Dual Scheimpflug Analyzer G4 in this study.
Repositioning of malpositioned peripherally inserted central catheter lines with the use of intracavitary electrocardiogram: A pediatric case series
Authors: Weber Mark D , Himebauch Adam S , Conlon Thomas 
Published: July 2019

Introduction: Peripherally inserted central catheter tip migration is an infrequent event that occurs in neonatal, pediatric, and adult patients. We discuss a novel technique of utilizing intracavitary electrocardiogram to help confirm proper peripherally inserted central catheter tip repositioning, thereby reducing the need for serial radiographs. Case presentation: A case series of four patients will be discussed. The first three patients had peripherally inserted central catheter tips that were initially appropriately positioned but had later peripherally inserted central catheter tip migration. The use of intracavitary electrocardiogram was able to confirm the appropriate repositioning of the peripherally inserted central catheters without the need for serial radiographs. The fourth patient had several central lines in place, which led to difficulty in identifying the peripherally inserted central catheter tip location. The use of intracavitary electrocardiogram confirmed proper positioning of his peripherally inserted central catheter tip when standard radiographs could not provide clarity. Discussion: Several techniques have been published on methods to reposition a migrated peripherally inserted central catheter tip back to the superior vena cava/right atrial junction. These repositioning techniques often require fluoroscopic guidance or a confirmatory radiograph to assess the appropriate peripherally inserted central catheter tip location. At times, several radiographs may be required before the tip is successfully repositioned. This novel application of intracavitary electrocardiogram can help to minimize radiographs when peripherally inserted central catheter tip repositioning is required.
Streptococcus pneumoniae as a Cause of Community-Acquired Pneumonia in Indian Adolescents and Adults: A Systematic Review and Meta-Analysis
Authors: Ghia Canna J. , Dhar Raja , Koul Parvaiz A , Rambhad Gautam , Fletcher Mark A 
Published: July 2019

Background: Streptococcus pneumoniae is one of the primary cause of community-acquired pneumonia (CAP) worldwide. However, scant data are available on the prevalence of etiological organisms for CAP in adolescent and adult Indian population. Objective: We performed a systematic review and meta-analysis to determine the contribution of S. pneumoniae in the causation of CAP in Indian patients aged 12 years or above. Methodology: We performed a systematic search of both indexed and non-indexed publications using PubMed, databases of National Institute of Science Communication and Information Resources (NISCAIR), Annotated Bibliography of Indian Medicine (ABIM), Google Scholar, and hand search including cross-references using key terms ‘community acquired pneumonia AND India’. All studies, published between January 1990 and January 2017, that evaluated Indian patients aged above 12 years with a confirmed diagnosis of CAP were eligible for inclusion. Our search retrieved a total of 182 studies, of which only 17 and 12 qualified for inclusion in the systematic review of all etiological organisms, and meta-analysis of S. pneumonia, respectively. Results: A total of 1435 patients met the inclusion criteria. The pooled proportion of patients with S. pneumoniae infection was 19% (95% confidence interval [CI]: 12%-26%; I2 = 94.5% where I2 represents heterogeneity, P < .01). Other major etiological agents are Mycoplasma pneumoniae (15.5% [1.1%-35.5%]), Klebsiella pneumoniae (10.5% [1.6%-24.0%]), and Legionella pneumophila (7.3% [2.5%-23.8%]). Conclusions: Analysis found approximately a one-fifth proportion of adult Indian patients of CAP with S. pneumoniae infection, suggesting it as a leading organism for causing CAP compared with other etiological organisms.
Role of Serum and Urinary Biomarkers in Evaluation and Management of Patients With Overactive Bladder
Authors: Trivedi Sameer , Patnaik Pranab , Ramole Yashpal , Khan Faiz Ahmed , Srivastava Ragini , Dwivedi Udai Shankar 
Published: July 2019

Background:This study compared urinary and serum nerve growth factor levels and serum C-reactive protein levels in patients with overactive bladder, before and after treatment with antimuscarinic agents, to evaluate their diagnostic and therapeutic importance.Methods:This was a prospective case-control study conducted between February 2014 and December 2014 which included patients with a confirmed diagnosis of overactive bladder (overactive bladder group) and healthy controls (control group). All patients visiting urology out-patient department with urgency, frequency, and urge incontinence were assessed for overactive bladder and, if eligible, were enrolled in the study. Biomarkers were evaluated before in both groups and after antimuscarinic treatment in the overactive bladder group.Results:Overall, 80 participates were enrolled (overactive bladder, n = 40; control, n = 40). The mean age was not different between the two groups (overactive bladder, 48.6 years; control, 46.9 years [ P = 1.01]) and females were more in both the groups (60% and 55%, respectively). The majority (70%) of patients presented with frequency and urgency. After 3 months of treatment with antimuscarinics, the mean overactive bladder symptom score decreased significantly from 8.4 to 4.85 ( P < .001). The mean urinary and serum nerve growth factor levels and serum C-reactive protein levels also decreased significantly from baseline after 3 months of treatment with antimuscarinics (24.78 pg/mL, 22.46 pg/mL, 0.89 mg/L, respectively; P < .0001).Conclusions:Measurement of urinary and serum nerve growth factor levels has diagnostic and therapeutic potential in patients with overactive bladder.
Revisiting the Role of Private Schooling on Children Learning Outcomes: Evidence from Rural India
Authors: Singhal Karan , Das Upasak 
Published: July 2019

In the view of increasing preference of private schooling in India, this article assesses its impact on learning outcomes for rural children from 8 to 11 years. Despite earlier attempts to study the issue, this article stands out in two ways. Firstly, it addresses the problems arising because of non-random selection of children attending private schools. Secondly, it also presents an all-India estimate unlike most studies which have dealt largely with few states. Our results show the performance of children attending private school to be significantly better than those from public schools. This difference is evident among ‘low-fee’ private schools as well. However the private schooling premium differ across regions and groups, and there are several other concerns regarding affordability, access and segregation which require further deliberation and debate. JEL: I2, I21, I28
Metabolic bone disease in patients diagnosed with inflammatory bowel disease from Spain
Authors: Miranda-Bautista José , Verdejo Cristina , Díaz-Redondo Alicia , Bretón Irene , Bellón José M. , Pérez-Valderas María Dolores , Caballero-Marcos Aránzazu , de Dios-Lascuevas Marta , González-Río Elena , García-Sánchez Cristina , Marín-Jiménez Ignacio , Bañares Rafael , Menchén Luis 
Published: July 2019

Background: The objective of this study was to analyse the prevalence of metabolic bone disease (MBD) in a cohort of Southern European patients with inflammatory bowel disease (IBD) and to identify associated risk factors in this population. Methods: We conducted a retrospective, both cross-sectional and longitudinal study of MBD, assessed by dual energy X-ray absorptiometry (DXA), among patients diagnosed with IBD and previously recognized risk factors for this complication from two referral Spanish institutions. Results: A total of 612 patients (58.6% diagnosed with Crohn’s disease) were included. Mean (SD) age was 44.9 (14.7) years; 71.7% of patients received at least one tapered dosage of corticosteroids before first DXA. MBD and osteoporosis were diagnosed in 66.4% and 21.4% of patients, respectively. At baseline, male gender, menopause and ulcerative colitis were found as independent risks factors for osteoporosis, whereas age, more than three IBD-related hospitalizations and previous steroid treatment were found as independent risks factors for MBD. A total of 261 patients had at least a second DXA and were included in the longitudinal study; median follow up was 56.4 months. Logistic regression model identified menopause, ulcerative colitis and baseline lumbar DXA T-score value, but not steroid treatment, as risk factors for worsening ⩾1 SD in follow-up DXA T-score. According to guidelines, all patients under treatment with corticosteroids received calcium and vitamin D supplements. Conclusion: MBD is a frequent complication in south-European IBD patients. Routine evaluation of bone density when risk factors are present, as well as calcium plus D vitamin prophylaxis in patients under corticosteroid treatment should be recommended.
Sepsis alters the transcriptional and translational landscape of human and murine platelets
Authors: Middleton Elizabeth A. , Rowley Jesse W. , Campbell Robert A. , Grissom Colin K. , Brown Samuel M. , Beesley Sarah J. , Schwertz Hansjörg , Kosaka Yasuhiro , Manne Bhanu K. , Krauel Krystin , Tolley Neal D. , Eustes Alicia S. , Guo Li , Paine Robert , Harris Estelle S. , Zimmerman Guy A. , Weyrich Andrew S. , Rondina Matthew T. 
Published: July 2019

Abstract
In a Plenary Paper, Middleton and colleagues describe important transcriptional and translational changes in murine and human platelets during sepsis, elucidating the emerging role of platelets in the complications of systemic inflammatory illness.
Obtaining Knowledge in Pathology Reports Through a Natural Language Processing Approach With Classification, Named-Entity Recognition, and Relation-Extraction Heuristics
Authors: Oliwa Tomasz , Maron Steven B. , Chase Leah M. , Lomnicki Samantha , Catenacci Daniel V.T. , Furner Brian , Volchenboum Samuel L. 
Published: July 2019

PURPOSE Robust institutional tumor banks depend on continuous sample curation or else subsequent biopsy or resection specimens are overlooked after initial enrollment. Curation automation is hindered by semistructured free-text clinical pathology notes, which complicate data abstraction. Our motivation is to develop a natural language processing method that dynamically identifies existing pathology specimen elements necessary for locating specimens for future use in a manner that can be re-implemented by other institutions. PATIENTS AND METHODS Pathology reports from patients with gastroesophageal cancer enrolled in The University of Chicago GI oncology tumor bank were used to train and validate a novel composite natural language processing-based pipeline with a supervised machine learning classification step to separate notes into internal (primary review) and external (consultation) reports; a named-entity recognition step to obtain label (accession number), location, date, and sublabels (block identifiers); and a results proofreading step. RESULTS We analyzed 188 pathology reports, including 82 internal reports and 106 external consult reports, and successfully extracted named entities grouped as sample information (label, date, location). Our approach identified up to 24 additional unique samples in external consult notes that could have been overlooked. Our classification model obtained 100% accuracy on the basis of 10-fold cross-validation. Precision, recall, and F1 for class-specific named-entity recognition models show strong performance. CONCLUSION Through a combination of natural language processing and machine learning, we devised a re-implementable and automated approach that can accurately extract specimen attributes from semistructured pathology notes to dynamically populate a tumor registry.