bluuebunny/crossref_metadata_2025_split huggingface dataset:
Особливості використання знаменного розспіву в духовних творах ірини денисовоЇ (на прикладі Херувимських пісень g-moll та e-moll)
Authors: Варакута М. І. , Суміна К. Б. 
Published: August 2018

Мета статті – проаналізувати регенерацію традицій знаменного розспіву та їх включення в сучасний церковно-хоровий простір, які є важливим фактором професійного формування майбутнього хорового диригента. У статті розглядаються особливості використання знаменного розспіву в контексті сучасного сприйняття. Методологія дослідження визначена комплексним музикознавчим та історико-типологічним аналізами. Наукова новизна статті полягає у розкритті особливостей використання знаменного розспіву в Херувимських піснях композитора Ірини Денисової. У публікації висвітлюється художня своєрідність, творча самобутність композиторської обдарованості майстрині у період до прийняття чернечого постригу та вже після ствердження композиторкою шляху монахині. Висновки. Застосування знаменного розспіву може бути тільки в його гармонізації, не в аранжуванні і навіть не в обробці, тому що їх прийоми допускають проведення основної теми в різних партіях, а подібне „поводження” зі знаменним розспівом є неприпустимим. Особливості використання знаменного розспіву полягають в тому, щоб не вийти за рамки інтонаційно-емоційної сфери самого розспіву гармонізуючи його. У подібній обмеженості композитор, який гармонізує знаменний розспів може збагатити його за рахунок динаміки, ритміки, плагальних гармоній, але кардинально, значимо й істотно тільки за допомогою фактурно-гармонічних перетворень, звідки і зʼявляються терміни „фактуризаціяˮ і „гармонізаціяˮ. Процес гармонізації знаменного розспіву Ірини Денисової і монахині Іуліанії (Денисової) хоч і не значні, але має відмінності. Гармонізація написана після прийняття чернечого постригу (Херувимська е mоll) відрізняється точною традиційністю, строгістю форми викладу музичного матеріалу, в піснеспіві вже не відчувається прагнення до концертності, а є тільки стан молитовності.
Бенд Leleka Berlin: український фольклор і джаз
Authors: Тулянцев А. А. , Сазонова М. В. 
Published: August 2018

Мета статті полягає у розкритті індивідуальності виконавського стилю етно-джаз-бенду Leléka berlin, у виявлені особливостей синтезу його професійних музично-сценічних взаємодій, а також в аналізі професійних якостей відповідного інструментально-вокального виконавства. З персоною Вікторії Антон та її колег-інструменталістів можна визначити актуальну цінність міжнародної творчої діяльності етно-джаз-бенду Leléka berlin, зрозуміти його специфіку, окреслити професійні можливості, розкрити особливості творчих пошуків сучасних музикантів, а також з’ясувати умови ефективної діяльності такого квартету, як етно-джаз-бенд Leléka berlin у сучасному соціумі. Методологія дослідження зумовлюється емпіричною природою наукової розвідки, яка формує превалювання у статті таких дослідницьких методів як спостереження та узагальнення. Саме ці методи дозволяють, перш за все, розкрити творчу індивідуальність етно-джаз-бенду Leléka berlin. Наукова новизна. Вперше в історії українського музикознавства зроблена спроба розглянути феномен етно-джаз-бенду Leléka berlin, який було створено у 2016 році. Аналіз взаємовпливу інструментального та вокально-сценічного напрямків у сучасному естрадному мистецтві виявив актуальні особливості концертної діяльності етно-джаз-бенду Leléka berlin, як міжнародного музичного явища та сценічного видовища. Висновки. Зроблено музикознавчий аналіз, повʼязаний з обгрунтуванням інструментально-вокальної моделі етно-джаз-бенду Leléka berlin, що обумовлює фольклорне продовження в сучасному міжнародному естрадному виконавстві. Вокально-інструментальна ансамблевість, що підпорядковує собі всю концертну та гастрольну діяльність, – основа дієвого функціонування етно-джаз-бенду Leléka berlin, на якому будується вся система його критеріїв сучасної музичної пропаганди українського фольклору. Концерти, гастролі, виступи етно-джаз-бенду Leléka berlin на Магдебургзькому міжнародному театральному фестивалі підтверджують той факт, що виконавці вкладають у гру та спів власне світовідчуття, своєрідно розкривають образний світ українського фольклору у його джазовій обробці.
Comparative Effectiveness of an mTOR-Based Systemic Therapy Regimen in Advanced, Metaplastic and Nonmetaplastic Triple-Negative Breast Cancer
Authors: Basho Reva K. , Yam Clinton , Gilcrease Michael , Murthy Rashmi K. , Helgason Thorunn , Karp Daniel D. , Meric-Bernstam Funda , Hess Kenneth R. , Valero Vicente , Albarracin Constance , Litton Jennifer K. , Chavez-MacGregor Mariana , Hong David , Kurzrock Razelle , Hortobagyi Gabriel N. , Janku Filip , Moulder Stacy L. 
Published: August 2018

Abstract

Background
Triple-negative breast cancer (TNBC) is a heterogeneous disease with subtypes having different “targetable” molecular aberrations. Metaplastic breast cancers (MpBCs) are typically TNBCs and commonly have alterations in the PI3K/Akt/mTOR pathway. We previously reported efficacy for an mTOR-based chemotherapy regimen in MpBC. To determine if tumor subtype influences prognosis, we compared treatment outcomes of patients with MpBC with those of patients with nonmetaplastic TNBC receiving an mTOR-based systemic therapy regimen.

Patients and Methods
Patients with advanced MpBC and nonmetaplastic TNBC were treated at our institution from April 16, 2009, through November 4, 2014, using mTOR inhibition (temsirolimus or everolimus) with liposomal doxorubicin and bevacizumab (DAT/DAE). Median progression-free survival (PFS) and overall survival (OS) were estimated by the Kaplan-Meier method. Cox regression analyses were used to evaluate associations between tumor histology and outcomes. Multivariable models were adjusted for all covariates.

Results
Fourteen patients with nonmetaplastic TNBC and 59 patients with advanced MpBC were treated with DAT/DAE. MpBC patients were older (p = .002) and less likely to have a history of bevacizumab use (p = .023). Median PFS for the nonmetaplastic TNBC and MpBC patients was 2.5 months and 4.8 months, respectively. This difference in PFS was statistically significant on univariable (p = .006) but not multivariable analysis (p = .087). Median OS for the nonmetaplastic TNBC and MpBC patients was 3.7 months and 10.0 months, respectively (p = .0003). MpBC remained significantly associated with improved OS on multivariable analysis (p &lt; .0001).

Conclusion
In our study, DAT/DAE appeared to be more effective in MpBC compared with nonmetaplastic TNBC. These data support patient selection for targeted therapy in TNBC.

Implications for Practice
Metaplastic breast cancers (MpBCs) represent &lt;1% of all breast cancers, demonstrate mesenchymal differentiation, and are typically resistant to chemotherapy. Patients with advanced MpBC treated with an mTOR-based systemic therapy regimen had better long-term outcomes compared with patients with nonmetaplastic triple-negative breast cancer treated with the same regimen, suggesting that metaplastic histology may predict benefit from agents targeting the PI3K/Akt/mTOR pathway.
Anti-fibrinolytic agents in bleeding disorders – A clinical perspective
Authors: Badle Saket , Hart Daniel P. 
Published: August 2018

Abstract
Tranexamic acid (TXA) is a synthetic antifibrinolytic drug used widely used to control bleeding complications in a wide variety of clinical situations. Soon after its development in the 1960s it found use in treatment of women with menorrhagia, and in inherited bleeding disorders. Subsequently it was used in surgery and with proven efficacy to reduce transfusion requirements and bleeding complications. Recent meta-analysis have provided further evidence of efficacy and safety. Tranexamic acid is now on the World Health Organization’s (WHO) list of essential drugs, and is the focus of ongoing worldwide trials. Similarly, there is increasing evidence base in both congenital and acquired bleeding disorders. We present a clinical narrative of the antifibrinolytic system and associated drugs to accompany the pharmacy review by Chaplin et al, with the aim of highlighting the evolution of TXA use in bleeding disorders over recent decades.
Live poultry vaccines against highly pathogenic avian influenza viruses
Authors: Boravleva Elizaveta , Gambaryan Alexandra 
Published: August 2018

ABSTRACT
The widespread circulation of highly pathogenic avian influenza viruses (HPAIVs) and their occasional transmission to humans creates a constant pandemic threat and leads to significant economic losses in the poultry industry. The development of an effective and safe vaccine for the broad protection of poultry from H5N1 HPAIVs remains an important goal. Prevention of the virus transmission between ducks and chickens is important for the efficient control of the spread of avian influenza. The oral administration of live vaccines corresponds to the natural route of infection that leads to virus replication in the intestinal epithelial cells that cause a well-balanced and broad immune response providing protection against the viruses of distant clades. The broad protection is the important advantage of live-attenuated influenza vaccines when compared to inactivated ones. Here, we give an overview of the latest approaches and results in the development of live poultry vaccine candidates against HPAIVs.
Práticas funerárias no baixo rio tapajós, Amazônia
Authors: Fonseca Diego Barros 
Published: August 2018

O artigo trata de uma série de urnas e vasilhas relacionadas a práticas de sepultamento provavelmente de indígenas Mundurucu, no baixo rio Tapajós, vindos do sítio arqueológico Nossa Senhora do Perpétuo Socorro (N.S.P. Socorro) - Itaituba, Pará. Avalia-se então as semelhanças com dados etnohistóricos e arqueológicos sobre as práticas funerárias na região, a descrição das escavações em laboratório, apresentando dados e interpretações sobre os vestígios osteológicos encontrados, contribuindo com os debates sobre as práticas funerárias na região Amazônica.
A relevância do contexto lingüístico na aquisição da fonologia e nos desvios fonológicos do desenvolvimento: o exemplo da palatalização
Authors: Matzenauer-Hernandorena Carmen Lúcia 
Published: August 2018

Focusing the palatalization of coronal stops, a study with children acquiring Brazilian Portuguese, in normal and deviant process, makes clear a significant influence of the linguistic context in the behavior of consonantal segments, causing phonetic effects of co-articulation. In the analysis of the data, theoretical model based in constraints, as Optimality Theory, and dynamic model, as Articulatory Phonology, show more consistency in the explanation of context dependent phenomenon, like palatalization, than Autosegmental Theory, that demands a mixed solution, with the use of rules and also the use of output constraints.
Apresentação
Authors: Koch Ingedore Grunfeld Villaça , Morato Edwiges Maria 
Published: August 2018

A idéia da elaboração deste número dos Cadernos de Estudos Lingüísticos surgiu por ocasião do II Congresso Internacional da ABRALIN, realizado em Fortaleza, em março de 2001, de cuja programação constavam dois eventos relacionados sobre referenciação, um Simpósio e uma Mesa-redonda. O primeiro desses eventos, intitulado “Referenciação, interação e discurso”, teve a feliz oportunidade de contar com a participação da Profa. Dra. Lorenza Mondada (então vinculada à Universidade de Basiléia, Suíça, e hoje atuando na Universidade de Lyon, França), que se encontrava no Brasil como professora-visitante no IEL, além do Prof. Dr. Luiz Antônio Marcuschi, da UFPE, e das duas organizadoras deste volume. O segundo reuniu três doutorandos do IEL na área de Lingüística Textual, sob a orientação de Ingedore Koch: Graziela Zamponi, Maria Luíza da Cunha Lima e Antônio Carlos Xavier.
Separation axioms on function spaces defined on bitopological spaces
Authors: Muturi N. E. , Khalagai J. M. , Pokhariyal G. P. 
Published: August 2018

In this paper, we introduce separation axioms on the function space p− Cω(Y, Z) and study how they relateto separation axioms defined on the spaces (Z, δi) for i = 1, 2, (Z, δ1, δ2), 1 − Cς(Y, Z) and 2 − Cζ(Y, Z). Itis shown that the space p − Cω(Y, Z) is pT◦, pT1, pT2 and pregular, if the spaces (Z, δ1) and (Z, δ2) are bothT0, T1, T2 and regular respectively. The space p − Cω(Y, Z) is also shown to be pT0, pT1, pT2 and pregular,if the space (Z, δ1, δ2) is p − T0, p − T1, p − T2 and p-regular respectively. Finally, the space p − Cω(Y, Z) isshown to be pT0, pT1, pT2 and pregular, if and only if the spaces 1 − Cς(Y, Z) and 2 − Cζ(Y, Z) are both T0,T1, T2, and only if the spaces 1 − Cς(Y, Z) and 2 − Cζ(Y, Z) are both regular respectively.
Systemic Factors and Barriers That Hamper Adequate Data Collection on the HIV Epidemic and Its Associated Inequalities in Countries With Long-Term Armed Conflicts: Lessons From Colombia
Authors: Alzate Angel Juan C. , Pericàs Juan M. , Taylor Holly A. , Benach Joan 
Published: August 2018

Although advances in treatment and diagnosis have transformed HIV into a chronic disease in high-income countries, a spectrum of structural, political, sociocultural, and health system barriers hamper early diagnosis and timely treatment of HIV in many middle- and low-income countries. In most Latin American countries, in spite of the great improvement in access to antiretroviral therapy, a large proportion of individuals infected with HIV do not know their status. In Colombia, the Joint United Nations Programme on HIV/AIDS currently estimates a much larger number of HIV cases than the number reported by Colombian authorities. Potential reasons for underdiagnosis and underreporting include sociocultural factors such as social stigma, restrictions in access to health care, a lack of public health research and robust surveillance systems, and the particular recent history and social situation related to the armed conflict the country has suffered through for several decades. Lessons from Colombia may be helpful in monitoring, understanding, and tackling the HIV epidemic in countries with long-term armed conflicts.
The Pregnancy Risk Assessment Monitoring System (PRAMS): Overview of Design and Methodology
Authors: Shulman Holly B. , D’Angelo Denise V. , Harrison Leslie , Smith Ruben A. , Warner Lee 
Published: August 2018

Data System. The Pregnancy Risk Assessment Monitoring System (PRAMS) is an ongoing state-based surveillance system of maternal behaviors, attitudes, and experiences before, during, and shortly after pregnancy. PRAMS is conducted by the Centers for Disease Control and Prevention’s Division of Reproductive Health in collaboration with state health departments.Data Collection/Processing. Birth certificate records are used in each participating jurisdiction to select a sample representative of all women who delivered a live-born infant. PRAMS is a mixed-mode mail and telephone survey. Annual state sample sizes range from approximately 1000 to 3000 women. States stratify their sample by characteristics of public health interest such as maternal age, race/ethnicity, geographic area of residence, and infant birth weight.Data Analysis/Dissemination. States meeting established response rate thresholds are included in multistate analytic data sets available to researchers through a proposal submission process. In addition, estimates from selected indicators are available online.Public Health Implications. PRAMS provides state-based data for key maternal and child health indicators that can be tracked over time. Stratification by maternal characteristics allows for examinations of disparities over a wide range of health indicators.
Weaponized Health Communication: Twitter Bots and Russian Trolls Amplify the Vaccine Debate
Authors: Broniatowski David A. , Jamison Amelia M. , Qi SiHua , AlKulaib Lulwah , Chen Tao , Benton Adrian , Quinn Sandra C. , Dredze Mark 
Published: August 2018

Objectives. To understand how Twitter bots and trolls (“bots”) promote online health content. Methods. We compared bots’ to average users’ rates of vaccine-relevant messages, which we collected online from July 2014 through September 2017. We estimated the likelihood that users were bots, comparing proportions of polarized and antivaccine tweets across user types. We conducted a content analysis of a Twitter hashtag associated with Russian troll activity. Results. Compared with average users, Russian trolls (χ2(1) = 102.0; P < .001), sophisticated bots (χ2(1) = 28.6; P < .001), and “content polluters” (χ2(1) = 7.0; P < .001) tweeted about vaccination at higher rates. Whereas content polluters posted more antivaccine content (χ2(1) = 11.18; P < .001), Russian trolls amplified both sides. Unidentifiable accounts were more polarized (χ2(1) = 12.1; P < .001) and antivaccine (χ2(1) = 35.9; P < .001). Analysis of the Russian troll hashtag showed that its messages were more political and divisive. Conclusions. Whereas bots that spread malware and unsolicited content disseminated antivaccine messages, Russian trolls promoted discord. Accounts masquerading as legitimate users create false equivalency, eroding public consensus on vaccination. Public Health Implications. Directly confronting vaccine skeptics enables bots to legitimize the vaccine debate. More research is needed to determine how best to combat bot-driven content.
Effects of the Affordable Care Act on Private Insurance Coverage and Treatment of Behavioral Health Conditions in Young Adults
Authors: Olfson Mark , Wall Melanie , Barry Colleen L. , Mauro Christine , Mojtabai Ramin 
Published: August 2018

Objectives. To assess changes in private insurance coverage and behavioral treatment of people aged 19 to 25 years and 26 to 35 years following the 2010 Affordable Care Act (ACA) dependent care provision and 2014 insurance reforms. Methods. We extracted data from the 2008 to 2016 US National Surveys on Drug Use and Health. We used an adjusted difference-in-differences approach to assess effects of age group on change in coverage. Replications in subgroups with serious psychological distress or substance use disorders also assessed change in mental health and substance use treatment. Results. Between 2008 to 2010 and 2011 to 2013, the increase in coverage of the younger group significantly differed from the decrease in the older group, but the 2 groups did not significantly differ between 2011 to 2013 and 2014 to 2016 (+3.2 percentage points; P < .001; and +3.8 percentage points; P < .001). Similar trends occurred among the distressed subgroups and the younger but not older substance use subgroup who reported no significant coverage changes in either period. A minority in the distressed (31.4%–45.4%) and substance use (5.1%–8.5%) subgroups received treatment. Conclusions. Although implementation of the ACA provisions coincided with coverage gains for young adults, challenges persist in engaging those with mental health and substance use problems in treatment.
Using Publicly Available Data to Understand the Opioid Overdose Epidemic: Geospatial Distribution of Discarded Needles in Boston, Massachusetts
Authors: Bearnot Benjamin , Pearson John F. , Rodriguez Jorge A. 
Published: August 2018

Objectives. To use publicly available, crowdsourced data to understand geospatial trends in discarded needles. Methods. We completed multiple geospatial analyses of discarded needles reported through the Boston, Massachusetts, 311 service request system. Results. Between May 2015 and August 2017, 4763 discarded needles were reported. The highest concentration of needles were reported in census block groups in the South End and Roxbury neighborhoods. Cumulatively, 78.3% of the needles were reported within 1 kilometer of methadone clinics, safe needle deposit sites, homeless shelters, or hospitals. Conclusions. Publicly reported data can help identify hot spots of discarded needles and examine indicators of spatial association. In Boston, the number of discarded needles being reported is rising, with the highest density of needles found in 2 central neighborhoods with several outlying hot spots. Most needles were found near areas associated with social stress and substance use disorder. Public Health Implications. This analysis represents a novel way of leveraging publicly available information to target community responses to the opioid epidemic. Identifying hot spots of discarded needles may enable public health organizations to target future efforts to encourage safer needle disposal practices and reduce public injection drug use.
Drinking Water Violations and Environmental Justice in the United States, 2011–2015
Authors: McDonald Yolanda J. , Jones Nicole E. 
Published: August 2018

Objectives. To assess the extent to which drinking water violations in the United States differed on the basis of county race/ethnicity and socioeconomic status using the primary county served by the community water system (CWS) as the unit of analysis and to determine whether counties with higher proportions of underrepresented groups were disproportionately burdened with repeat violations. Methods. We used multivariable logistic regression to calculate odds ratios of contextual environmental justice covariates associated with initial and repeat drinking water violations. We obtained violations from the federal Safe Drinking Water Information System. Results were nonstratified and stratified on the basis of population size served by the CWS. Results. Stratified multivariable logistic regression results revealed previously unobservable patterns in nonstratified findings. Minorities face significant challenges, including exposure to poor water quality. The most notable differences in both initial and repeat violations that we observed were among CWSs that serve large populations. Our most consistent finding was the positive association of initial and repeat violations with the proportion of those who were uninsured, irrespective of stratification. Conclusions. Greater efforts are needed to ensure that counties with higher proportions of minorities, uninsured households, and low-income households have access to safe drinking water, irrespective of the size of population served by the CWS.