bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proyecto comunitario ambiente y territorio: manejo y disposición de residuos sólidos en la vereda pueblo viejo Moniquirá (Boyacá)
Authors: Pita- Morales Luz Adriana , Páez –Saavedra Julián David , Puerta- Gutiérrez Nasly Susana 
Published: April 2019

Propósito: el presente artículo tiene como propósito socializar el avance del trabajo comunitario realizado en materia de manejo de residuos sólidos en la vereda pueblo viejo del municipio de Moniquirá- Boyacá. Temas: en este sentido, el creciente deterioro del ambiente causado por la disposición inadecuada de residuos sólidos trae como consecuencia la degradación de recursos y paisajes en el área rural, por tal motivo surge la necesidad de realizar un acompañamiento e interacción con los habitantes de la vereda con el fin de responder a la necesidad de actuar de manera comunitaria e interinstitucional en la problemática ambiental generada por los desechos. Desarrollo: el proyecto se desarrolló con un enfoque mixto, donde se aborda el método descriptivo constructivista como hilo conductor del ejercicio. Conclusiones: los resultados reflejan la manera como los habitantes de la vereda pueblo viejo perciben su territorio y el impacto que genera en él los residuos sólidos, así como las entidades que de una u otra manera han contribuido en la región con el tema, posteriormente se realizó un procesos de sensibilización en el cuidado de los recursos naturales de la región el cual se inicia con los habitantes de la vereda a través de los colegios rurales.
Ergen kızlarda polikistik over sendromu: klinik, endokrin ve metabolik bulgular
Authors: ÖZCABI Bahar , TAHMİSCİOĞLU BUCAK Feride , ŞENGENÇ Esma , SUNAMAK Evrim , ADALETLİ İbrahim , KURUĞOĞLU Sebuh , ERCAN Oya , EVLİYAOĞLU Olcay 
Published: April 2019

Amaç:
Polikistik over sendromu tanısı alan ergen kızların başvurudaki klinik, metabolik
ve endokrin bulgularını değerlendirmeyi amaçladık.Gereç-Yöntemler: Ocak 2008-Aralık 2012 tarihleri arasında Rotterdam tanı ölçütlerine göre tanılandırılan
53 olgunun yakınmaları, adet düzenleri, fizik bakı bulguları (antropometrik
ölçümler, Ferriman Gallwey skoru, akantozis nigrikans varlığı), bazal/uyarılmış
adrenal androjen, açlık glukoz/insülin değerleri, kan yağ ve lipoprotein
düzeyleri, pelvik ultrasonografi bulguları kaydedildi. Yaşa göre vücut kitle
indeksi (VKİ) %95 ve üzeri olgular şişman olarak tanımlandı. Oligo/amenore,
hiperandrojenizm ve ultrasonografide polikistik over bulgularının hepsinin bulunduğu
hastalar klasik grup olarak adlandırıldı. Kan trigliserit düzeyi yaşa göre %97
değerinden fazla ise yüksek olarak nitelendirildi; HOMA-IR değeri ≥ 3,82 olgularda
insülin direnci var kabul edildi.Bulgular:
Ortalama başvuru yaşı 15±1,5 yıldı. En sık yakınma adet düzensizliğiydi
(%49,1). Adet düzeni ayrıntılı sorgulandığındaysa olguların %60,4’ünde oligo/amenore
olduğu görüldü. Olguların %43,4’ü
şişmandı. Akantozis nigrikans (%37,7) olan olgularda şişmanlık daha sıktı
(p=0.010). Hirsutizm %41,5 olguda orta-ağır (Ferriman Gallwey skoru≥16) olarak
belirlendi: orta-ağır olgularda oligo/amenore daha sıktı (p=0,007).
İnsülin direnci %39,6 olguda (%81 obez) vardı ve akantozis nigrikans
saptananlarda daha sıktı (p=0,001). Trigliserit
yüksekliği 49 olgudan 7’sinde saptandı; bu olguların hepsinde insülin direnci de
mevcuttu (p=0,033). Serum trigliserit düzeyi ile HOMA-IR değeri arasında
korelasyon saptandı (r:0,415). Polikistik over bulgusu olguların % 96,2’sinde
belirlendi. Klasik grupta diğer gruba göre oligo/amenore, hirsutizm, akantozis
nigrikans, trigliserit yüksekliği anlamlı (p&lt;0.005), total testosteron
düzeyi anlamlılığa yakın yüksekti (p=0.056).

Sonuç: Polikistik
over sendromu tanısında adet düzeni ayrıntılı olarak sorgulanmalıdır. Akantozis
nigrikans saptanan olgular insülin direnci açısından irdelenmeli, insülin
direnci varlığında trigliserit yüksekliği araştırılmalıdır.
Intraoperative Doppler ultrasound of the cavernous part of the internal carotid artery in endoscopic transsphenoidal removal of the laterosellar tumors
Authors: Sharipov O. I. , Fomichev D. V. , Kutin M. A. , Kalinin P. L. 
Published: April 2019

The study objective is to describe the technique of intraoperative Doppler ultrasound (DU) of brain arteries and to determine the indications for its use during endoscopic transsphenoidal operations. Materials and methods. The study included 100 patients with skull base tumors (pituitary adenomas, trigeminal schwannomas, chordomas), operated via standard or extended transsphenoid endoscopic approaches. For DU, the location of the internal carotid artery (ICA) relative to the surface of the tumor or dura mater was determined as a red and/or blue color of the monitor screen in the M-mode window, accompanied by a characteristic sound signal. Results. DU was used to remove pituitary adenomas in 95 cases, trigeminal schwannomas in 3 cases, chordomas in 2 cases. Intraoperative DU helped to locate the ICA during removal of the laterosellar part of the tumor in all observations. In none of the cases presented were no injuries to the ICA. Сonclusion. DU is an effective and non-invasive method for detecting ICA during endoscopic operations which contributes to the safe disposal of laterosellar tumors. Adequate use of the method does not carry well-known and potential risks. DU should be performed when the tumor is removed from the cavernous sinus or its projection via the lateral extended transsphenoidal endoscopic access (to determine the safe boundaries of the dura mater section in the cavernous sinus projection).
Hellmann Potential in Spinless Salpeter Equation with Potential Barrier within the Framework of Nikiforov-Uvarov method
Authors: Antia Akaninyene Daniel 
Published: April 2019

<p>In this paper, we have solved the spinless Salpeter equation (SSE) with Hellmann potential under the framework of NIkiforov-Uvarov (NU) method. The energy eigenvalues and corresponding wave functions for this system express in terms of the Jacobi polynomial are also obtained. With the help of approximation scheme the potential barrier has been evaluated. The results obtained in this work would have many applications in nuclear physics, chemical physics, atomic and molecular physics, molecular chemistry and other related areas as the results under limiting cases could be used to study the binding energy and interaction of some diatomic molecules. As a guide to interested readers, we have provided numerical data which discuss the energy spectra for this system.</p><p> </p>
Ruch pokojowy w RFN (Friedensbewegung) w pierwszej połowie lat osiemdziesiątych XX wieku
Authors: Świder Małgorzata 
Published: April 2019

<p>W latach 80. XX wieku ruch pokojowy mobilizujący setki tysięcy osób w protestach przeciwko podwójnej uchwale NATO z grudnia 1979 r. był istotnym elementem zachodnioniemieckiej sceny politycznej. Wpływał na układ sił i konflikty wewnętrzne w socjaldemokracji niemieckiej (SPD); będąc największym oponentem polityki prowadzonej przez rząd kanclerza Helmuta Schmidta, przyczynił się do powstania Partii Zielonych, a jego działania doprowadziły do zaistnienia polemiki w związkach zawodowych i były bodźcem do dyskusji etycznych i religijnych w Kościele katolickim i protestanckim w RFN. Stał się również przedmiotem wielu kontrowersji oraz symbolem aktywności i siły społecznej.</p>
PEGIDA – polityczny ruch protestu
Authors: Macała Jarosław Edward 
Published: April 2019

<p>Ruchy protestu związane ze skrajną prawicą działają w Niemczech na przestrzeni wielu lat. Jednak żaden nie zyskał takiego rozgłosu i poparcia jak antyislamska PEGIDA. Ten ruch protestu przez swoje niekonwencjonalne, lecz z reguły pokojowe i legalne protesty dotyczące polityki migracyjnej zintegrował i zmobilizował wiele tysięcy niezadowolonych Niemców. Zmusił też do reakcji elity polityczne oraz zmobilizował przeciwników PEGIDY wśród społeczeństwa niemieckiego. Pokazał dużą frustrację i niezadowolenie części obywateli. Wydaje się, iż celowo przesadzona groźba islamizacji Niemiec i Europy to pretekst dla zwolenników PEGIDY, żeby w sposób typowy dla wielu politycznych ruchów protestu pokazać swoją antyestablishmentowość, niezadowolenie z tradycyjnego sposobu uprawiania niemieckiej polityki, z alienacji elit politycznych, z arogancji władzy. W programie i działalności PEGIDY silne jest populistyczne rozróżnienie między „nami”, czyli normalnymi ludźmi, a „nimi”, czyli oderwanymi od rzeczywistości przedstawicielami elit. Celem jest zmiana modelu niemieckiej demokracji w kierunku demokracji bezpośredniej, żeby głos obywateli liczył się bardziej niż elit.</p>
The role of occupational health services in the universal health coverage era in Indonesia
Authors: Mansyur Muchtaruddin 
Published: April 2019

In accordance to Act No 24 Year 2011 on The Social Security Administrating Body, the Indonesian National Social Security program is managed by two national organizations, namely: Social Security Administering Body for Health (Badan Penyelenggara Jaminan Sosial Kesehatan = BPJS Kesehatan) and Social Security Administering Body for Labor (Badan Penyelenggara Jaminan Sosial Ketenagakerjaan = BPJS Ketenagakerjaan). The former is responsible for providing health coverage for all Indonesians through the National Social Health Insurance Scheme known as the Jaminan Kesehatan Nasional/JKN. The latter is responsible for providing the worker's social security consisting of Provident Fund Benefit, Accident Benefit, Pension Benefit, and Death Benefit.1The Indonesian government has been continuously improving the health service program towards better national universal health coverage and has set the 2019 functional achievement target of 95% of the population enrolled in the program. To ensure that this target of the program will be achieved, the government pays the premium of BPJS Kesehatan of the poor and near poor.2
A clinical study of hyperreactive airway disease with wheeze in children aged five to twelve years with special reference to pulmonary function test
Authors: Reddy Arjun , Patel Abhishek , Chetty Sanjeev 
Published: April 2019

Background: Pulmonary function test is the easiest and most cost-effective method to evaluate respiratory functions. PFT can be measured by a simple instrument spirometer. Measuring PFT has been suggested as an important tool in understanding HRAD and its complications and management by all international guidelines. The objectives of this study were to clinically diagnose the hyperreactive airway disease in children coming to Navodaya Medical College, Raichur, of age group 5 to 12 years. And to perform pulmonary function test before and after the use of a bronchodilator.Methods: PFT was measured in 100 children who came with HRAD with wheeze using Spiro lab III spirometer. The child was given then nebulization with salbutamol and PFT was performed again after 30 min.Results: A total of 100 clinically diagnosed cases of HRAD of age group 5 to 12 years of both the gender was taken into the study, of which more than 44% of the children showed more than 20% improvement in parameters FEV1, PEF, FVC and marginal improvement in EV1/FVC post bronchodilator compared to their prebronchodilator parameters. The young children of both the gender showed better improvement than elder children.Conclusions: Spirometry is the best tool to assess HRAD even in younger children, early diagnosis and regular follow up with PFT helps to understand and prevent the progression of the disease with prompt treatment.
Prevalence of new-onset migraine in patients with idiopathic intracranial hypertension in comparison to the general population
Authors: Togha Mansoureh , Shirbache Kamran , Rahmanzadeh Reza , Ghorbani Zeinab , Yari Zahra , Refaeian Farshid , Behbahani Shirin , Panahi Parsa 
Published: April 2019

Background: Idiopathic intracranial hypertension (IIH) encompasses patients with elevated intracranial pressure (ICP). Generally, it is difficult to make a differential diagnosis between IIH and co-existing migraine headaches. Thus, this article intends to estimate the prevalence of migraine in patients with IIH and explain the occurrence of new-onset migraine after the diagnosis of IIH.
Methods: The case group included 108 patients with IIH referred to the neurology wards of three university hospitals. A random sample of controls (n = 103) were recruited from patients hospitalized in the surgery and orthopedics ward. A checklist for migraine diagnosis was filled out. Cerebrospinal fluid (CSF) pressure and presence or absence of papilloedema (PE) in the patients and any necessary data were also recorded from the inpatient medical documents. All statistical analyses were done by SPSS software.
Results: There were 70 (64.80%) and 22 (21.40%) migraineurs in the case and control groups, respectively, and the difference was found to be
significant (P < 0.001). In 26 (37.14%) migraine cases in the IIH group, the disorder was diagnosed after developing IIH. Also, there was a past medical history of having migraine in 44 (62.85%) migraineurs. In the fully adjusted regression models, the odds of being affected by migraine in patients with IIH was 6.17 times greater than the controls [odds ratio (OR) = 7.15, 95% confidence interval (CI) = 3.56-14.36, P < 0.010]. The patients’ mean CSF opening pressure was 32.10 ± 1.03 cmH2O and 93 (81.60%) subjects were found to have PE.
Conclusion: It was demonstrated that subjects with IIH might have about a 6-time higher likelihood of developing migraine headache than the general population. These considerations can help prevent misdiagnosis of migraine headache as the recurrence of IIH or uncontrolled IIH and subsequent inappropriate management.
Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression
Authors: Long Pan , Yan Weiming , He Mengshan , Zhang Qianli , Wang Zhe , Li Manhong , Xue Junhui , Chen Tao , An Jing , Zhang Zuoming 
Published: April 2019

Abstract
Background: Oxidative stress (OS) is an essential factor in the pathogenesis of branch retinal vein occlusion (BRVO). Studies have demonstrated the role of hydrogen gas in the regulation of OS. This study was designed to evaluate the effecacy of hydrogen gas on the BRVO rat model.
Methods: Twenty-four BRVO rats were randomly divided into two groups: the hydrogen gas (H) group (42% H2, 21% O2, 37% N2) and the model (M) group (21% O2, 79% N2). Rats in the H group inhaled hydrogen gas for 8 h every day up to 30 d post-occlusion. Twelve age-matched healthy rats served as the control (C) group. Retinal function and morphology were detected at 1, 7, 14 and 30 d post-occlusion. Furthermore, the expression of vascular endothelial growth factor (VEGF-α) was detected by immunofluorescent staining.
Results: Full-field electroretinography (ffERG) revealed that the amplitude of the b-wave (dark-adaptation 3.0 response), the amplitude of the OPs2 wave and the light-adapted flicker response in the H group were all higher than those in the M group at 7 d post-occlusion (all p<0.05). The reopen time of occlusive retinal vessels in the H group was 2.235 ± 1.128 d, which was shorter than that in the M group (4.234±2.236 d, p<0.05). The rats in the H group had a thinner IPL+GCL+NFL and an increased total retina compared with those in the M group at 3 d post-occlusion (p<0.05), while the rats in the H group had a thicker INL, IPL+GCL+NFL and total retina compared with those at 7, 14 and 30 d post-occlusion (p<0.05). Moreover, the flow velocity of ear vein blood was increased in the H group compared with that in the M group (p<0.05). The expression of VEGF-α in the H group was dramatically decreased compared with that in the M group at 1, 7 and 14 d post-occlusion (p<0.05), while the expression kept in similar level at 30 d post-occlusion (p>0.05).
Conclusions: Our findings demonstrate that inhalation of hydrogen gas could alleviate retinal oedema, shorten reopen time and improve retinal function, and the potential mechanism might be related to a decrease in VEGF-α expression.
Protocol for aquaphotomics monitoring of water molecular structure in leaves of resurrection plants during desiccation and recovery
Authors: Muncan Jelena , Kuroki Shinichiro , Moyankova Daniela , Morita Hiroyuki , Atanassova Stefka , Djilianov Dimitar , Tsenkova Roumiana 
Published: April 2019

Abstract
Plant stress responses are complex phenomena encompassing an array of changes at molecular and cellular level. They leave imprint on the molecular structure of water in the plant tissues which can be measured in vivo, in a completely non-destructive and reagent-free way, using aquaphotomics near infrared spectroscopy. Analysis of the near infrared spectrum regions, where water absorbs, provides indirect insight into the dynamics and functionality of the whole biological system.In our efforts to perform Responsible Research and Innovations (RRI) practices, we display openly the details of our approach showing the advantages and the eventual difficulties. The protocol described here is developed for non-destructive monitoring of plant response to desiccation stress, particularly focused on the extreme desiccation tolerance of resurrection plants. With alterations in plant material and experimental conditions, the methods described allow detection, monitoring and analysis of plant response to stress in general - abiotic and biotic.
Exploration of candidate serum biomarkers potentially related to the chronic pain condition in Medication Overuse Headache (MOH)
Authors: Pellesi Lanfranco , Bellei Elisa , Guerzoni Simona , Cainazzo Maria Michela , Baraldi Carlo , Monari Emanuela , Pini Luigi Alberto 
Published: April 2019

Abstract
Background

Medication Overuse Headache (MOH) is a prevalent and disabling disorder resulting from the overuse of analgesic drugs, triptans or other acute headache medications. In previous proteomic studies, several proteins have been found at high concentrations in the urine of MOH patients and in the serum of rats with neuropathic pain. The aim of this study was to compare the serum levels of lipocalin-type Prostaglandin D2 synthase (L-PGDS), Vitamin D-binding protein (VDBP), apolipoprotein E (APOE) and apolipoprotein A1 (APOA1) in MOH patients and healthy individuals, further exploring their relationship with cutaneous pain thresholds (CPTs) in the territories innervated by the trigeminal nerve.

Methods

69 MOH patients and 42 age- and sex-matched healthy volunteers were enrolled in the study. Von Frey-like filaments were applied to the skin territories innervated by the trigeminal nerve, to determine the CPTs. L-PGDS, VDBP, APOE and APOA1 were quantified in the serum by Enzyme-linked Immunosorbent Assay (ELISA). Clinical and laboratory data were collected. Comparisons between MOH patients and healthy individuals were performed using independent t test or χ2 test. To correlate serum proteins with CPTs, Pearson correlation coefficient or Spearman's rank correlation coefficient were used.

Results

CPTs were lower among MOH patients. L-PGDS, VDBP and APOE had significantly different serum concentrations between groups (p < 0.01), but no correlation was found with CPTs. APOA1 serum concentrations did not differ between patients and healthy individuals.

Conclusions

L-PGDS, VDBP and APOE had abnormal serum levels in MOH patients, confirming their alteration in some conditions of chronic headache and neuropathic pain. The in-depth study of target proteins represents a promising approach for a better understanding of MOH, as well as the detection of candidate biomarkers for chronic headache or the risks associated with overuse medications.
On Rare Variants in Principal Component Analysis of Population Stratification
Authors: Ma Shengqing , Shi Gang 
Published: April 2019

Abstract
Background

Population stratification is a known confounder of genome-wide association studies, as it can lead to false positive or false negative results. Principal component analysis (PCA) method is widely applied in the analysis of population structure with common variants. It is still controversial whether this method is effective when using rare variants to distinguish population stratification.

Results

In this work, we derive a mathematical expectation of the genetic relationship matrix. Variance and covariance elements of the expected matrix depend explicitly on allele frequencies of the genetic markers used in the PCA analysis. We show analytically that inter-population variance is contained in K principal components (PCs) and mostly in the largest K-1 PCs, where K is the number of populations in the samples. When allele frequencies become small, the ratio of the inter-population variance in the K PCs to the intra-population variance abates, the portion of variance explained by the K PCs decreases, and the distance among populations diminishes. As a result, the PCA of population stratification performs worse with rare variants than with common ones. The results are validated in the analysis of the 1000 Genomes Project data. The ratio of the two variance components is 93.85, variance explained by the largest five PCs is 17.09%, and population distance is 444.38 when using with common variants with allele frequencies between 0.4 and 0.5. However, the ratio, percentage and distance decrease to 1.83, 0.74% and 17.83, respectively, with rare variants of frequencies between 0.0001 and 0.01.

Conclusions

Although the vast majority of rare variants are population-specific and may have richer ancestry information than common ones, new methods must be developed to exploit the information effectively.
Phospholipid Fatty Acid Profiles of Soils under Variable Handling and Storage Conditions
Authors: Veum Kristen S. , Lorenz Todd , Kremer Robert J. 
Published: April 2019

Core Ideas
Sample handling had profound and disproportionate effects on PLFA biomarkers.
Gram positive and actinobacteria were not significantly affected by storage.
Gram negative and fungal biomarkers were dramatically affected by storage.
PLFA ratios significantly changed as a result of sample handling and storage.
Interpretation of PLFA profiles is highly sensitive to sample handling.
ABSTRACTPhospholipid fatty acid (PLFA) analysis is an increasingly popular method for estimating microbial biomass and assessing microbial community structure in soils. In particular, there is a strong interest in the use of PLFA microbial group ratios as benchmarks for soil health assessment and interpretation. Due to the sensitivity of PLFA biomarkers, the recommended procedure for sample handling involves immediate analysis of fresh, field‐moist soil, immediate lyophilization with freezer storage, or storage at –80°C. This protocol may not be practical under all circumstances, yet the effects of handling and storage conditions, and the implications for interpretation of PLFA biomarkers, are not fully understood. The primary objective of this study was to evaluate the effects of multiple sample handling and storage conditions on quantification and interpretation of PLFA biomarkers. A suite of soil properties were measured on 17 prairie soil samples, including PLFA analysis. Multiple processing and handling procedures were evaluated by splitting the soil samples and comparing PLFA profiles from (i) fresh soil, (ii) soil stored air‐dry for 7 and 14 d, (iii) soil stored field‐moist at room temperature for 7 and 14 d, and (iv) soil oven‐dried for 24 h at 105°C. All handling and storage procedures resulted in significant losses of PLFA biomarkers relative to fresh, lyophilized samples and microbial groups were disproportionately affected, leading to significant shifts in biomarker ratios. Overall, this study highlights the sensitivity of PLFA biomarkers, the importance of proper sample handling for PLFA analysis, and the potential for error and misinterpretation of PLFA data.