bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Foveal Cone Photoreceptor Topography and its Dependence on Eye Length
Authors: Wang Yiyi , Bensaid Nicolas , Tiruveedhula Pavan , Ma Jianqiang , Ravikumar Sowmya , Roorda Austin 
Published: March 2019

AbstractWe provide the first measures of foveal cone density as a function of axial length in living eyes and discuss the physical and visual implications of our findings. We used a new generation Adaptive Optics Scanning Laser Ophthalmoscope to image cones at and near the fovea in 28 eyes of 16 subjects. Cone density and other metrics were computed in units of visual angle and linear retinal units. The foveal cone mosaic in longer eyes is expanded at the fovea, but not in proportion to eye length. Despite retinal stretching (decrease in cones/mm2), myopes generally have a higher angular sampling density (increase in cones/deg2) in and around the fovea compared to emmetropes, offering the potential for better visual acuity. Reports of deficits in best-corrected foveal vision in myopes compared to emmetropes cannot be explained by increased spacing between photoreceptors caused by retinal stretching during myopic progression.
Omics of the early molecular dialogue between Frankia alni and Alnus glutinosa and the cellulase synton
Authors: Pujic Petar , Alloisio Nicole , Fournier Pascale , Roche David , Sghaier Haitham , Miotello Guylaine , Armengaud Jean , Berry Alison M. , Normand Philippe 
Published: March 2019

SummaryThe early Frankia‐Alnus symbiotic molecular exchanges were analyzed in detail by protein and RNA omics. For this, Frankia cells were placed in the presence of Alnus roots but separated by a dialysis membrane for 64 h. The bacterial cells were then harvested and analyzed by high‐throughput proteomics and transcriptomics (RNA‐seq). The most upregulated gene clusters were found to be the potassium transporter operon kdp and an ABC transporter operon of uncharacterized function. The most upregulated proteins were found to be acyl dehydrogenases and the potassium transporter Kdp. These suggest a preadaptation to the impending stresses linked to the penetration into isotonic host tissues and a possible rearrangement of the membrane. Another cluster among the 60 most upregulated ones that comprised two cellulases and a cellulose synthase was conserved among the Frankia and other actinobacteria such as Streptomyces. Cellulase activity was detected on CMC all along the length of the root but not away from it. Frankia alni ACN14a was found to be unable to respire or grow on glucose as sole carbon source. The cellulose synthase was found active at the tip of hyphae in response to Alnus root exudates, resulting in a calcofluor stained tip.
The field of graduate recruitment: leading financial and consultancy firms and elite class formation
Authors: Donnelly Michael , Gamsu Sol 
Published: March 2019

AbstractThe symbolic value of being recruited by a high status multinational company likely represents an important marker of distinction. For the first time, a unique Destinations of Leavers in Higher Education (DLHE) data‐set is used here to model entry to elite multinational company in finance, accountancy and consultancy sectors among graduates of different social origins, universities, degree subjects and with different degree classifications. From a sample of 11,755 graduates working across these three sectors, we examine what predicts entry to 31 leading firms and then examine pay hierarchies among the 3,260 graduates working for these companies using random‐effects models. At first glance, significantly, we find that elite recruits come from a much broader range of universities than might be imagined. However, a closer look at the highest paid graduates within these firms reveals more familiar patterns of social and institutional stratification. We argue that these patterns likely reflect the nature of work undertaken by graduates in these elite firms, with institutional and social origins of graduates differing according to the particular track taken in what are likely to be highly differentiated graduate recruitment schemes.
An r package and online resource for macroevolutionary studies using the ray‐finned fish tree of life
Authors: Chang Jonathan , Rabosky Daniel L. , Smith Stephen A. , Alfaro Michael E. 
Published: March 2019

Abstract

Comprehensive, time‐scaled phylogenies provide a critical resource for many questions in ecology, evolution and biodiversity. Methodological advances have increased the breadth of taxonomic coverage in phylogenetic data; however, accessing and reusing these data remain challenging.

We introduce the Fish Tree of Life website and associated r package fishtree to provide convenient access to sequences, phylogenies, fossil calibrations and diversification rate estimates for the most diverse group of vertebrate organisms, the ray‐finned fishes. The Fish Tree of Life website presents subsets and visual summaries of phylogenetic and comparative data, and is complemented by the r package, which provides flexible programmatic access to the same underlying data source for advanced users wishing to extend or reanalyse the data.

We demonstrate functionality with an overview of the website, and show three examples of advanced usage through the r package. First, we test for the presence of long branch attraction artefacts across the fish tree of life. The second example examines the effects of habitat on diversification rate in the pufferfishes. The final example demonstrates how a community phylogenetic analysis could be conducted with the package.

This resource makes a large comparative vertebrate dataset easily accessible via the website, while the r package enables the rapid reuse and reproducibility of research results via its ability to easily integrate with other r packages and software for molecular biology and comparative methods.
Prevalence, radiographic resolution and outcomes of slab fractures of the third and central tarsal bones in juvenile Thoroughbred horses
Authors: Steel CM , Collins VL , Hance SR , Adkins AR , Hitchens PL 
Published: March 2019

BackgroundVeterinarians are required to interpret the significance of radiographic findings for sale, soundness and future racing performance of weanling and yearling Thoroughbreds. We investigated the prevalence and radiographic appearance of slab fractures of the third (T3) and central tarsal (Tc) bones.MethodsWeanling and yearling horses with complete or incomplete T3 or Tc fracture were identified by searching a database of radiographs. The prevalence and radiographic appearance at initial diagnosis and after continued pasture turnout, as well as prognosis for racing, of fractures of T3 and Tc were determined.ResultsFractures were identified in 186 tarsi (184 T3 fracture only, 1 Tc fracture only, 1 Tc and T3 fracture) of 157 horses (126 unilateral T3, 29 bilateral T3, 1 contralateral Tc and T3, 1 unilateral Tc and T3) from 7676 examinations. The prevalence of T3 and Tc fractures was 2.40 (95% CI 2.07, 2.76) and 0.04 (95% CI 0.01, 0.11) per 100 radiographic examinations respectively. Fractures were identified on the D556–65°MPlLO view and occurred by survey examination at 11.1 ± 1.3 months in 85.7% horses. At initial diagnosis, 84.3% of T3 fractures appeared incomplete and involved the distal articular surface. Fracture score improved (P < 0.001), and dorsal modelling (P < 0.001) and osteoarthritis score increased in the distal intertarsal joint (P < 0.001), but not the tarsometatarsal joint, between survey and repository examinations. Fractures healed by repository examination in 71.9% of tarsi if there was > 6 months between examinations. There was no difference in sale price, and horses with T3 fractures had fewer trials when 2 and 3 years old (P = 0.023), yet no difference in other parameters of racing success when 2 or 3 years old compared with controls.ConclusionTarsal slab fractures can occur in juvenile Thoroughbreds and most heal with continued pasture turnout of > 6 months. Further investigation is required to determine risk factors and before making firm conclusions regarding the optimal management, prognosis for racing and long‐term soundness.
Motile ciliogenesis and the mitotic prism
Authors: Al Jord Adel , Spassky Nathalie , Meunier Alice 
Published: March 2019

AbstractMotile cilia of epithelial multiciliated cells transport vital fluids along organ lumens to promote essential respiratory, reproductive and brain functions. Progenitors of multiciliated cells undergo massive and coordinated organelle remodelling during their differentiation for subsequent motile ciliogenesis. Defects in multiciliated cell differentiation lead to severe cilia‐related diseases by perturbing cilia‐based flows. Recent work designated the machinery of mitosis as the orchestrator of the orderly progression of differentiation associated with multiple motile cilia formation. By examining the events leading to motile ciliogenesis with a methodological prism of mitosis, we contextualise and discuss the recent findings to broaden the spectrum of questions related to the differentiation of mammalian multiciliated cells.
Determinants of left ventricular diastolic function—The Cardiovascular Risk in Young Finns Study
Authors: Heiskanen Jarkko S. , Ruohonen Saku , Rovio Suvi P. , Kytö Ville , Kähönen Mika , Lehtimäki Terho , Viikari Jorma S. A. , Juonala Markus , Laitinen Tomi , Tossavainen Päivi , Jokinen Eero , Hutri‐Kähönen Nina , Raitakari Olli T. 
Published: March 2019

Decreased left ventricular (LV) diastolic function is associated with increased all‐cause mortality and risk for a heart failure. The determinants of LV diastolic function have been mainly studied in elderly populations; however, the origin of LV heart failure may relate to the lifestyle factors acquired during the life course. Therefore, we examined biochemical, physiological, and lifestyle determinants of LV diastolic function in 34–49‐year‐old participants of the Cardiovascular Risk in Young Finns Study (Young Finns Study). In 2011, clinical examination and echocardiography were performed for 1928 participants (880 men and 1048 women; aged 34–49 years). LV diastolic function was primarily defined using E/é‐ratio (population mean 4.8, range 2.1–9.0). In a multivariate model, systolic blood pressure (P < 0.005), female sex (P < 0.005), age (P < 0.005), waist circumference (P = 0.024), smoking (P = 0.028), serum alanine aminotransferase (P = 0.032) were directly associated with E/é‐ratio, while an inverse association was found for height (P < 0.005). Additionally, a higher E/é‐ratio was found in participants with concentric hypertrophy compared to normal cardiac geometry (P < 0.005). Other indicators of the LV diastolic function including E/A‐ratio and left atrial volume index showed similarly strong associations with systolic blood pressure and age. In conclusion, we identified systolic blood pressure, waist circumference and smoking as modifiable determinants of the LV diastolic function in the 34–49‐year‐old participants of the Young Finns Study.
Circulating microRNA‐1246 as a possible biomarker for early tumor recurrence of hepatocellular carcinoma
Authors: Chuma Makoto , Toyoda Hidenori , Matsuzaki Juntaro , Saito Yoshimasa , Kumada Takashi , Tada Toshifumi , Kaneoka Yuji , Maeda Atsuyuki , Yokoo Hideki , Ogawa Koji , Kamiyama Toshiya , Taketomi Akinobu , Matsuno Yoshihiro , Yazawa Keiichi , Takeda Kazuhisa , Kunisaki Chikara , Ogushi Katsuaki , Moriya Satoshi , Hara Koji , Nozaki Akito , Kondo Masaaki , Fukuda Hiroyuki , Numata Kazushi , Tanaka Katsuaki , Maeda Shin , Sakamoto Naoya 
Published: March 2019

AimsEarly tumor recurrence (ETR) after hepatic resection is a crucial predictor of poor prognosis in patients with hepatocellular carcinoma (HCC). The aim of this study was to identify clinically significant serum microRNAs (miRNAs) involved in the ETR of HCC.MethodsWe compared expression profiles of circulating miRNAs from serum samples between five HCC patients with ETR (recurrence within 12 months after hepatectomy) and five HCC patients without recurrence using microarray analysis of miRNA. The identified miRNA associated with ETR was further verified in 121 HCC patients, 73 liver disease patients, and 15 health controls by real‐time quantitative reverse transcription–polymerase chain reaction (PCR).ResultsOf the approximately 2000 miRNAs analyzed, we identified 15 miRNAs for which expression levels correlated significantly with ETR. Of these miRNAs, we further investigated expression of miRNA‐1246 (miR‐1246). Quantitative PCR confirmed that miR‐1246 was upregulated in HCC with ETR, compared to the level in HCC without ETR (P < 0.001). Serum miR‐1246 showed a receiver operating characteristic curve area of 0.762, with 77.4% specificity and 54.1% sensitivity in discriminating HCC patients with ETR from HCC patients without ETR. Altered expression of miR‐1246 was associated with aggressive tumor characteristics, including tumor–node–metastasis classification (P = 0.0413), tumor differentiation (P = 0.0419), and portal vein invasion (P = 0.0394). Moreover, multivariate Cox regression analysis identified serum miR‐1246 level as an independent risk factor for overall survival (hazard ratio, 2.784; 95% confidence interval, 1.528–5.071; P = 0.0008).ConclusionCirculating miR‐1246 in serum has strong potential as a novel ETR and prognostic biomarker for HCC.
Mindsets of health and healthy eating intentions
Authors: Thomas Fanice N. , Burnette Jennifer L. , Hoyt Crystal L. 
Published: March 2019

AbstractAcross two studies, we examined the relation between mindsets of health, expectancy‐value, and eating intentions. We also explored if relations are stronger for African Americans compared to White Americans. In Study 1, we conducted a correlational study (N = 158) to examine initial relations among constructs. In Study 2, we employed an experimental design (N = 205), and randomly assigned participants to either a growth mindset or a fixed mindset of health condition. In both studies, we measured participants’ mindsets of health, expectancy‐value beliefs, healthy eating intentions, past eating habits, and demographics. In Study 1, stronger growth mindsets of health predicted healthier eating intentions. Expectancy‐value beliefs, namely, the extent to which individuals value healthy eating habits and expect to be able to manage their eating, mediated this relation. In Study 2, we successfully manipulated mindsets of health and individuals in the growth mindset condition reported healthier eating intentions, compared to those in the fixed mindset condition. Expectancy‐value beliefs again mediated this link. Race only moderated the relation in Study 1, such that effects of growth mindsets on outcomes (i.e., eating intentions and expectancy‐value beliefs) are stronger for African Americans compared to White Americans. Study 1 provided initial evidence of a relationship between stronger growth mindsets of health and healthier beliefs and intentions. Study 2 offered experimental evidence. We discuss theoretical and practical implications.
The synergistic effects of clopidogrel with montelukast may be beneficial for asthma treatment
Authors: Trinh Hoang Kim Tu , Nguyen Thuy Van Thao , Choi Youngwoo , Park Hae‐Sim , Shin Yoo Seob 
Published: March 2019

AbstractPlatelets modulate asthma pathogenesis by forming the platelet‐eosinophil aggregation (PEA), which facilitates the activation of eosinophils. Platelets exhibit the purinergic receptor (P2Y12R), which responds to cysteinyl leukotriene E4 (LTE4). We have suggested that the combination of an antiplatelet drug (clopidogrel, [Clo]) and montelukast (Mon) would synergistically suppress asthma. BALB/c mice were intraperitoneally sensitized with ovalbumin (OVA) on days 0 and 14 and subsequently challenged on days 28‐30 and 42‐44. Mice were administered with Clo (10 mg/kg), Mon (10 mg/kg) or both drugs (Clo/Mon) orally 30 minutes before the OVA (1%) challenge on days 42‐44. Mice were assayed for airway hyper‐responsiveness (AHR) to methacholine and airway inflammation. Clopidogrel and montelukast attenuated the increased AHR; the combined treatment was more effective than a single treatment for total and eosinophil counts (all P < 0.05). Levels of interleukin (IL)‐4, IL‐5, IL‐13, platelet factor 4, eosinophil peroxidase and LTE4 increased in the bronchoalveolar lavage fluid of asthmatic mice, but these levels decreased in mice treated with Clo/Mon (all P < 0.05). Goblet cell hyperplasia decreased in response to Clo/Mon. Mouse platelets and eosinophils were isolated and co‐cultured for an in vitro assay with 10 µmol/L adenosine diphosphate (ADP), LTE4 (200 nmol/L), Mon (1 µmol/L), Clo (1 µmol/L) and Clo/Mon (1 µmol/L). Flow cytometry revealed that the increased formation of the PEA (%) was fully mediated by ADP and partly mediated by LTE4. Clo/Mon reduced ADP‐induced PEA formation and P‐selectin expression (P < 0.05). In conclusion, Clo/Mon synergistically relieved asthma by inhibiting ADP‐mediated PEA formation.
Raddeanin A down‐regulates androgen receptor and its splice variants in prostate cancer
Authors: Xia Hongyan , Hu Cheng , Bai Shanshan , Lyu Jing , Zhang Bryan Y. , Yu Xianghui , Zhan Yang , Zhao Lijing , Dong Yan 
Published: March 2019

AbstractCastration‐resistant progression of prostate cancer is a major cause of prostate cancer mortality, and increased expression and activity of the full‐length and the splice variants of androgen receptor (AR) have been indicated to drive castration resistance. Consequently, there is an urgent need to develop agents that can target both the full‐length and the splice variants of AR for more effective treatment of prostate cancer. In the present study, we showed that raddeanin A (RA), an oleanane‐type triterpenoid saponin, suppresses the transcriptional activities of both the full‐length and the splice variants of AR. This is attributable to their decreased expression as a result of RA induction of proteasome‐mediated degradation and inhibition of the transcription of the AR gene. We further showed the potential of using RA to enhance the growth inhibitory efficacy of docetaxel, the first‐line chemotherapy for prostate cancer. This study identifies RA as a new agent to target both the full‐length and the splice variants of AR and provides a rationale for further developing RA for prostate cancer treatment.
Trends in Multidisciplinary Hazard and Disaster Research: A 1982–2017 Case Study
Authors: Behrendt Adam , Lukasiewicz Kathryn , Seaberg Daniel , Zhuang Jun 
Published: March 2019

AbstractFrom 1982 to 2017, 539 unique awards studying extreme events and natural disasters have been funded by the Infrastructure Management and Extreme Events (IMEE), Decision, Risk and Management Science (DRMS), Humans, Disasters, and the Built Environment (HDBE), and Hazard Science, Engineering, and Education for Sustainability (Hazard SEES) programs under the National Science Foundation, totaling approximately $450 million. The relationships between discipline, topic, and funding are explored through review of the data on each award's active dates, amount of funding received, specific hazards and disasters studied, and principal investigator (PI) and co‐PI affiliations. A positive correlation between award funding and increasingly larger multidisciplinary teams of PIs on projects is observed. However, these teams of four or more PIs only account for about 18% of the total number of awards. In terms of topic, projects applicable to general hazard/disaster research encompass the largest portion of awards, but not the greatest funding per award on average. Additionally, both the number of awards per year and the total funds allotted per year show an increasing trend. Finally, some of the trends in project team discipline with relation to hazards show a shift to equal numbers of engineers and social scientists on multidisciplinary teams while others remain fairly homogeneous in their team dynamics. This article provides unique perspectives on how to better allocate funds through extensive topic and funding analysis. This work is a brief analysis of trends in the hazard and disaster research community, focusing on multidisciplinary project teams and their correlation to funding amounts and research areas.
Prohibitions caused by nonlocality for nonlocal Boussinesq‐KdV type systems
Authors: Lou S. Y. 
Published: March 2019

AbstractIt is found that two different celebrate models, the Korteweg de‐Vrise (KdV) equation and the Boussinesq equation, are linked to a same model equation but with different nonlocalities. The nonlocal KdV equation can be derived in two ways, via the so‐called consistent correlated bang companied by the parity and time reversal from the local KdV equation and via the parity and time reversal symmetry reduction from a coupled local KdV system which is a two‐layer fluid model. The same model can be called as the nonlocal Boussinesq system if the nonlocality is changed as only one of parity and time reversal. The nonlocal Boussinesq equation can be derived via the parity or time reversal symmetry reduction from the local Boussinesq equation. For the nonlocal Boussinesq equation, with help of the bilinear approach and recasting the multisoliton solutions of the usual Boussinesq equation to an equivalent novel form, the multisoliton solutions with even numbers and the head on interactions are obtained. However, the multisoliton solutions with odd numbers and the multisoliton solutions with even numbers but with pursuant interactions are prohibited. For the nonlocal KdV equation, the multisoliton solutions exhibit many more structures because an arbitrary odd function of can be introduced as background waves of the usual KdV equation.
The influence of combined vegetation stalk thickness on water flow resistance
Authors: Zhang Shengtang , Wang Zhikai , Liu Ying , Li Guibao , Chen Si , Liu Ming 
Published: March 2019

AbstractVegetation that exists in the natural environment often involves a combination of plants with different stalk thicknesses. This combination affects the hydrodynamic properties of the ground surface, which in turn changes the velocity and distribution of run‐off. Current research on the influence of vegetation stalk thickness on water flow resistance is mostly focused on uniform vegetation. There have been few studies on the influence of non‐uniform vegetation on water flow resistance, and most have been qualitative in nature. In order to study the quantitative relationship between combinations of different stalk thicknesses and the water flow resistance of slope vegetation, a laboratory experiment was performed using a flume. The results show that when two different plant stalk thicknesses are staggered and combined, the diameters of the plants exhibit a power function relationship with the Darcy‐Weisbach resistance coefficient. When the diameter of the stem of one of the plants remains constant, at the same water depth, the coefficient of water flow resistance increases with the diameter of the stem of the other plant. Additionally, the coefficient of the vegetation flow resistance increases with increasing water depth. In the non‐submerged state, as the water depth increases, the rate at which the water flow resistance coefficient increases gradually declines, and as the diameter of any plant stem increases, the rate at which the water flow resistance coefficient increases also declines gradually. These findings provide a theoretical basis for the prevention and control of soil erosion and have important practical implications for maintaining water and soil resources.