bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Strong Gravitationally Lensed Herschel Galaxy HLock01: Optical Spectroscopy Reveals a Close Galaxy Merger with Evidence of Inflowing Gas
Authors: Marques-Chaves Rui , Pérez-Fournon Ismael , Gavazzi Raphael , Martínez-Navajas Paloma I. , Riechers Dominik , Rigopoulou Dimitra , Cabrera-Lavers Antonio , Clements David L. , Cooray Asantha , Farrah Duncan , Ivison Rob J. , Jiménez-Ángel Camilo E. , Nayyeri Hooshang , Oliver Seb , Omont Alain , Scott Douglas , Shu Yiping , Wardlow Julie 
Published: February 2018

Abstract
The submillimeter galaxy (SMG) HERMES J105751.1+573027 (hereafter HLock01) at z = 2.9574 ± 0.0001 is one of the brightest gravitationally lensed sources discovered in the Herschel Multi-tiered Extragalactic Survey. Apart from the high flux densities in the far-infrared, it is also extremely bright in the rest-frame ultraviolet (UV), with a total apparent magnitude m
UV ≃ 19.7 mag. We report here deep spectroscopic observations with the Gran Telescopio Canarias of the optically bright lensed images of HLock01. Our results suggest that HLock01 is a merger system composed of the Herschel-selected SMG and an optically bright Lyman break-like galaxy (LBG), separated by only 3.3 kpc in projection. While the SMG appears very massive (M
* ≃ 5 × 1011
M
⊙), with a highly extinguished stellar component (A

V
≃ 4.3 ), the LBG is a young, lower-mass (M
* ≃ 1 × 1010
M
⊙), but still luminous (

) satellite galaxy. Detailed analysis of the high signal-to-noise ratio (S/N) rest-frame UV spectrum of the LBG shows complex kinematics of the gas, exhibiting both blueshifted and redshifted absorption components. While the blueshifted component is associated with strong galactic outflows from the massive stars in the LBG, as is common in most star-forming galaxies, the redshifted component may be associated with gas inflow seen along a favorable sightline to the LBG. We also find evidence of an extended gas reservoir around HLock01 at an impact parameter of 110 kpc, through the detection of C ii
λλ1334 absorption in the red wing of a bright Lyα emitter at z ≃ 3.327. The data presented here highlight the power of gravitational lensing in high S/N studies to probe deeply into the physics of high-z star-forming galaxies.
Real world experience with the all-oral interferon free regimen for the treatment of chronic hepatitis c virus infection in the Lebanese population
Authors: Saba Jowana , Abou Rached Antoine , Yaghi Cesar , Sharara Alaa , Ammar Walid 
Published: February 2018

Introduction: The treatment of hepatitis C has dramatically improved since the introduction of the new Direct-Acting Antivirals (DAAs). The aim of this study is to assess the effectiveness and safety of all oral DAAs with or without ribavirin in the treatment of hepatitis C virus (HCV) in treatment naïve and experienced Lebanese population.
Methodology: We reviewed all cases approved for hepatitis C treatment with DAAs according to the Lebanese guidelines for treatment of HCV at the Ministry of Public Health from October 2015 till December 2016. Available data concerning age, sex, mode of transmission, genotype (GT) and subtype, fibrosis stage, previous treatment (if present), new DAAs treatment, and sustained virological response at week 12 (SVR12) were collected.
Results: During a period of 15 months (October 2015 to December 2016), 186 patients were treated with DAAs. 57% were male and the mean age was 54.3 years. The source of infection was unknown in 51% of cases and blood transfusion in 35.5% of cases. Genotype 1 was the most predominant genotype (45%), followed by GT4 (34%) and GT3 (12%). 71.6% of patients had advanced fibrosis before starting DAAs and 57% were cirrhotic. 42% of patients were treatment experienced (85% pegylated interferon and ribavirin). Different DAAs regimens were used according to the Lebanese guidelines for treatment of HCV: Ledipasvir/Sofosbuvir (38.7%), Sofosbuvir/Daclatasvir (16.1%), Sofosbuvir/Velpatasvir (1.6%), Sofosbuvir/RBV (7.5%), Ombitasvir/Paritaprevir/Ritonavir (17.5%) and Ombitasvir/Paritaprevir/Ritonavir -Dasabuvir (18.8%). Ribavirin was used in 51.6% of cases. SVR12 was achieved in 93% of patients (relapse in 4%, loss of follow up and/or severe adverse effect in 3%). SVR 12 was achieved in 93%, 96% and 94% of GT1, GT3 and GT4 cases respectively. SVR12 was seen in 91.3% of cirrhotic patients vs. 98.7% of F0-F3 patients. (p = 0.047). There was no difference in SVR12 between treatment naïve and experienced patients. Hepatocellular carcinoma developed in 5 patients (2.9%) during the study period.
Conclusion: This is the first real world Lebanese data of HCV treatment with DAAs. The study population was significant for a large number of patients with cirrhotic (50%) and treatment experienced patients (42%). SVR12 was achieved in 93% of patients with no difference between treatment naïve and experienced patients. SVR12 was lower in patients with cirrhosis compared to patients with lower stage of fibrosis (91.3% vs. 98.7%).
The The importance of blood culture and serology for Brucellosis diagnosis and treatment
Authors: Faddoul Lama , Azar Rania , Haddad Antoine , Hanna Abi 
Published: February 2018

Introduction: Brucellosis is a zoonotic endemic disease in Lebanon. It is caused by direct transmission of Brucella from contaminated animal products to humans. If left untreated brucellosis might lead to several complications and a chronic disease state. The prompt diagnosis of brucellosis has the ability to limit the progression of the disease, especially if the correct treatment is administered for the adequate amount of time. The aim of this study is to determine the optimal diagnostic tool and to assess Brucella burden in Lebanon.
Methodology: This retrospective study was performed by reviewing the medical charts of 46 brucellosis patients from three Lebanese hospitals. Brucellosis diagnostic tests were compared and sensitivity of each test was calculated, as well as, the level of agreement with other standard diagnostic tools. Data retrieved were analyzed for relevance and statistical significance using the statistical package for social sciences version 23.
Results: Sensitivity results of the diagnostic tests were: Rose Bengal test (RBT) 94.7%, blood culture 65.6%, standard agglutination test (SAT) melitensis 95.1% and SAT abortus 97.6%. The level of agreement between RBT and SAT melitensis as well as abortus is 98% and 90.18%, respectively. While the level of agreement between Blood culture and SAT melitensis as well as abortus is 66.88% and 64.5%, respectively.
Discussion: Culture techniques require further optimization in order to find the best diagnostic tool for brucellosis. Meanwhile, Blood Rose Bengal test held a significant potential for identifying Brucella infection in a highly sensitive, cost effective and time saving manner.
The Brucella endocarditis: diagnostic challenges
Authors: Ephrem Christelle Georges , Matar Madonna J , Chalhoub Gaelle C , Greige Wafaa G 
Published: February 2018

Introduction: Brucellosis is a multisystemic infectious disease, which can manifest as endocarditis. Diagnosis can be challenging.
Case Presentation: An 80-year-old male patient presented with fever 38.5 °C, cough and progressive shortness of breath of 14 days. History of Brucellosis 18 months earlier inadequately treated. Physical examination showed a mid-frequency mitral and aortic murmur. Brucella serologies and blood cultures were positive. He was discharged on Doxycycline and Rifampicin for 3 months and was lost to follow up. Four months later, he presented for recurrent fever. Physical examination showed a radiating heart murmur. Blood cultures were negative; however, blocking antibodies were 1/2560. Echocardiography showed calcified aortic stenosis. TEE showed an abscess formation at the level of the non-coronary cusp. Ceftriaxone 3g IV q24h, gentamicin 80mg IV q8h, doxycycline 100mg po q12h and trimethoprim-sulfamethoxazole 160/800 mg po q12h were initiated (shortage of rifampicin). Aortic bio-prosthesis was successfully inserted, one week after initiating antibiotics. Intraoperative cultures were negative. He was discharged 18 days following surgery on doxycycline 100 mg po q12h, and rifampicin 900mg po q24h and ciprofloxacin 500mg po q 12h for 3 more months, with twice a month follow up.
Discussion: Endocarditis is one of the most lethal complication of Brucellosis. Early diagnosis and effective medical and surgical management are essential.
Administrer une ferme-modèle au xix e siècle : deux expériences d’agronomes entrepreneurs ruraux, Mathieu de Dombasle et Rieffel
Authors: Joly Nathalie , Bourrigaud René , Knittel Fabien 
Published: February 2018

En divers points de l’Europe du Nord et de l’Est, des fermes-modèles se créent à l’aube du xix e siècle, avec l’objectif de favoriser le progrès agricole par l’exemple et l’émulation entre propriétaires. Y sont expérimentés les principes d’une agriculture raisonnée visant les profits les plus élevés à partir de nouveaux procédés de culture et d’élevage. Cet article examine la contribution des fermes-modèles à l’histoire de la gestion de l’entreprise agricole, sur la base de deux établissements avant-gardistes en France : Roville et Grand-Jouan, le premier étant dirigé par une grande figure de l’agronomie, Mathieu de Dombasle, et le second par un ancien élève de l’Institut de Roville, Jules Rieffel. Il met en lumière les pratiques managériales et comptables d’une administration « savante » des domaines agricoles, les schémas de pensée qui l’inspirent et la panoplie d’outils lui servant de boussole. De ces laboratoires de l’agriculture raisonnée émergent de nouvelles disciplines au travail et un esprit de quantification qui participent à la transformation des rapports entre la technique et la gestion, la rationalité des décisions du chef d’entreprise étant désormais considérée comme déterminante dans le succès de l’entreprise agricole.
Orientation Process for Newly Credentialed Athletic Trainers in the Transition to Practice
Authors: Thrasher Ashley B. , Walker Stacy E. 
Published: February 2018

Context: Orientation is an important part of socialization and transition to practice, yet the orientation process for newly credentialed athletic trainers (ATs) is unknown.Objective: To determine how newly credentialed ATs are oriented to their roles.Design: Cross-sectional study.Setting: Online survey.Patients or Other Participants: Three hundred thirty-two of 1835 newly credentialed ATs (18%) certified and employed between January and September of 2013 completed the survey (129 men, 203 women; age = 23.58 ± 2.54 years).Data Collection and Analysis: The survey consisted of demographic information (eg, employment setting, job title) and 2 sections: (1) orientation tactics and (2) usefulness of orientation tactics. For the first section, participants identified if various orientation tactics were included in their orientations (eg, policies and procedures review). For the second section, participants identified how useful each orientation tactic was on a Likert scale (1 = not useful, 4 = very useful). Descriptive statistics were calculated for each survey item. Mann-Whitney U and Kruskal-Wallis tests were used to determine differences between demographic characteristics and orientation tactics. A Bonferroni correction accounted for multiple comparisons. A panel of experts established the content validity of the survey. The Cronbach α was used to establish internal consistency (α = 0.802)Results: The most common orientation tactics were meeting with supervisors (n = 276, 82.9%) and staff members (eg, coaches; n = 266, 79.9%) and learning responsibilities (n = 254, 76.2%). The least common orientation tactics were simulation of the emergency action plan (n = 66, 19.8%) and preceptor development (n = 71, 21.3%); however, preceptor development was not applicable to many participants. The most useful orientation tactics were simulating the emergency action plan (3.45/4.0) and meeting with staff members (3.44/4.0). Participants who felt their orientation prepared them for their roles were exposed to more tactics during orientation (Mann-Whitney U = 17 212, P &lt; .001).Conclusions: Many tactics were used to orient newly credentialed ATs to their roles, but orientations varied based on the practice setting.
Peripheral blood mononuclear cells of patients with latent autoimmune diabetes secrete higher levels of pro- & anti-inflammatory cytokines compared to those with type-1 diabetes mellitus following in vitro stimulation with β-cell autoantigens
Authors: Badal Darshan , Kumar Rajendra , Paul Mahinder , Dayal Devi , Bhansali Anil , Bhadada Sanjay Kumar , Kumar Rajesh , Sachdeva Naresh 
Published: February 2018

Background & objectives:
Type-1 diabetes mellitus (T1DM) and latent autoimmune diabetes in adults (LADA) share similar pathological features but differ in age of onset and progression. There is a scarcity of information on differences in CD4+ T-cell responses, particularly, cytokine secretion, between the two forms of autoimmune diabetes. Here proliferative potential and concentration of pro- and anti-inflammatory cytokines secreted by peripheral blood mononuclear cells (PBMCs) of T1DM and LADA patients were compared, after in vitro stimulation with β-cell autoantigens.

Methods:
A total of 19 patients with LADA, 37 with T1DM and 20 healthy controls were compared on the basis of lymphocyte proliferation and secretion of pro- and anti-inflammatory cytokines belonging to different T-helper types after in vitro stimulation of PBMCs with insulin and glutamic acid decarboxylase 65 (GAD65).

Results:
Following insulin stimulation, LADA group secreted higher concentration of interleukin-17 (IL-17) (P=0.02) and had higher proportion of interferon gamma (IFN-γ) secretors (P<0.001) than T1DM group. Post-GAD65 stimulation, higher proportion of LADA patients secreted IL-23 than T1DM group (P=0.02). Proportion of responders, as well as levels of secreted IL-10, were significantly higher in LADA than T1DM group, following stimulation with both insulin (P=0.01) and GAD65 (P=0.03). A significant positive correlation was observed between body mass index and IL-17 levels (r=0.41, P=0.04) and fasting plasma C-peptide with IL-10 levels (r=0.37, P=0.04).

Interpretation & conclusions:
There are differences in the portfolio of cytokine secretion in diabetic subjects with varying rates of β-cell destruction as LADA subjects secrete higher levels of both pro- and anti-inflammatory cytokines on exposure to β-cell autoantigens, thus highlighting another distinguishing feature in the pathophysiology of the two forms of autoimmune diabetes.
Modelling of cerebral tuberculosis in BALB/c mice using clinical strain from patients with CNS tuberculosis infection
Authors: Husain Aliabbas A. , Gupta Umesh Datta , Gupta Pushpa , Nayak Amit R. , Chandak Nitin H. , Daginawla Hatim F. , Singh Lokendra , Kashyap Rajpal Singh 
Published: February 2018

Background & objectives:
Central nervous system (CNS) infection caused by Mycobacterium tuberculosis (MTB) is the most severe form of extrapulmonary tuberculosis (EPTB) due to a high level of mortality and morbidity. Limited studies are available on CNS-TB animal model development. The present study describes the development of a murine model of CNS-TB using a clinical strain (C3) isolated from the cerebrospinal fluid (CSF) of CNS-TB patients.

Methods:
Groups of mice were infected by the intravenous route with MTB C3 strain isolated from the CSF of CNS-TB patients. Brain and lung tissue were evaluated for bacterial burden, histopathology and surrogate markers of TB infection at 30 and 50 days post-infection.

Results:
Mice infected intravenously with MTB C3 strains showed progressive development of CNS disease with high bacillary burden in lungs at the initial stage (30 days), which eventually disseminated to the brain at a later stage (50 days). Similarly, high mortality (60%) was associated in mice infected with C3 strain compared to control.

Interpretation & conclusions:
The study showed development of a novel murine model of CNS-TB using the C3 strain of MTB that replicated events of extrapulmonary dissemination. The developed model would be helpful in understanding the pathogenesis of CNS-TB infection for the development of improved therapeutic interventions in future.
Woronowicz Tannaka-Krein duality and free orthogonal quantum groups
Authors: Malacarne Sara 
Published: February 2018

Given a finite-dimensional Hilbert space $H$ and a collection of operators between its tensor powers satisfying certain properties, we give a short proof of the existence of a compact quantum group $G$ with a fundamental representation $U$ on $H$ such that the intertwiners between the tensor powers of $U$ coincide with the given collection of operators. We then explain how the general version of Woronowicz Tannaka-Krein duality can be deduced from this.
Blending coral restoration science and practice: A novel approach to Acropora population enhancement.
Authors: Levy Jessica S , Ripple Kayla J , Nedimyer Ken , Winters Scott R 
Published: February 2018

Florida and Caribbean coral reefs are in a state of unprecedented decline. Reefs once dominated by branching, hard-coral species, Acropora cervicornis and A. palmata, have lost upwards of 98% of Acroporid cover in recent decades. This decline is attributed to multiple, compounding factors. As these threats continue, there is a clear need for innovative methods to bolster remaining populations thus signaling to managers that intervention is needed to support recovery of the species. The urgency around coral decline has prompted practitioners to try a variety of restoration techniques. While promising, efforts need to incorporate best-practices of supporting genetic diversity, ecological function, and resiliency for successful coral restoration outcomes.
Herein we present novel approaches to coral population enhancement (coral restoration) that blend science and practice. Guided by NOAA’s Acropora Recovery Plan, we have implemented an ambitious restoration plan to outplant 50,700 corals using both Acropora species across eight reefs along the Florida Reef Tract. The restoration strategies presented here are designed to meet several population-based recovery objectives and criteria identified in the Acropora Recovery Plan including: increasing abundance, promoting genetic diversity, promoting recruitment, and disease mitigation (as informed by monitoring).
Antioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticles
Authors: Urbankova Lenka , Horky Pavel , Skladanka Jiri , Pribilova Magdalena , Smolikova Vendula , Nevrkla Pavel , Cernei Natalia , Lackova Zuzana , Hedbavny Josef , Ridoskova Andrea , Adam Vojtech , Kopel Pavel 
Published: February 2018

Background. The aim of the experiment was to determine the influence of sodium selenite and selenium nanoparticles on antioxidant status of rats.
Methods. The males of outbreed strain Wistar albino were selected as a model organism. Animals were fed with different forms of selenium. The control group was given mixture without selenium addition, whereas other groups were fed with mixture containing sodium selenite, Se-49 and Se-100 selenium nanoparticles, respectively. The duration of the trial was 30 days.
Results. The analysis of blood and liver was performed where concentration of reduced (GSH) and oxidized (GSSG) glutathione, and the total selenium content were measured. In liver, a significant reduction in GSSG was found in all experimental groups. Blood samples showed a significant reduction in GSH and an increase in GSSG.
Discussion. These results show that selenium nanoparticles may be an alternative to dietary selenium for the animal organism.
Kompetitive Allele Specific PCR (KASP™) genotyping of 48 polymorphisms at different caprine loci in French Alpine and Saanen goat breeds and their association with milk composition
Authors: Kusza Szilvia , Cziszter Ludovic Toma , Ilie Daniela Elena , Sauer Maria , Padeanu Ioan , Gavojdian Dinu 
Published: February 2018

Using a novel and fast genotyping method called Kompetitive Allele Specific PCR (KASP™), we carried out a pilot study on 48 single nucleotide polymorphisms (SNPs) belonging to 40 genes in French Alpine (n = 24) and Saanen (n = 25) goats reared in Romania. Furthermore, the associations of the 13 polymorphic genetic variants with milk production and composition were investigated. Thirty-five SNPs did not show polymorphism in the studied populations. Polymorphic SNPs were detected in the following genes:CAST, CLEC4E, DES, GHRHR, HSP90AA1, IL15RA, IL1RN, IL8, MITF, PPRC1, SOCS3, TNFandTNFSF13. The studied Alpine population was in Hardy-Weinberg disequilibrium at the g.62894878A>G locus (rs671391101) (P < 0.05). The results showed that four SNPsrs671391101(GHRHR),rs640582069(IL1RN)rs635583012(SOCS3) andrs635969404(IL15RA) out of the 13 polymorphic markers were significantly associated with milk production, protein, fat and lactose content in the Alpine breed. However, no significant effect was recorded in the Saanen population regarding milk yield or milk chemical composition. The current results provide new insights for the development of SNP marker-assisted selection technology in the goat industry and confirm the potential of using SNPs for theGHRHR,IL1RN,SOCS3, andIL15RAgenes as candidate genes for selection, highlighting the direct implications of such genes for farm production outputs. The results from this study are relevant for future goat genomic studies and the inclusion of the associated traits into up-to-date selection schemes.
Multiphase Structural Evolution of a Continental Margin During Obduction Orogeny: Insights From the Jebel Akhdar Dome, Oman Mountains
Authors: Grobe A. , Virgo S. , von Hagke C. , Urai J. L. , Littke R. 
Published: February 2018

AbstractThe structural evolution of the carbonate platform in the footwall of the Semail ophiolite emplaced onto the passive continental margin of Arabia helps to better understand the early stages of obduction‐related orogens. These early stages are rarely observable in other orogens as they are mostly overprinted by later mountain building phases. We present an extensive structural analysis of the Jebel Akhdar anticline, the largest tectonic window of the Oman Mountains, and integrate it on different scales. Outcrop observations can be linked to plate motion data, providing an absolute timeframe for structural generations consistent with radiometric dating of veins. Top‐to‐S overthrusting of the Semail ophiolite and Hawasina nappes onto the carbonate platform during high plate convergence rates between Arabia and Eurasia caused rapid burial and overpressure, generation and migration of hydrocarbons, and bedding‐confined veins, but no major deformation in the carbonate platform. At reduced convergence rates, subsequent tectonic thinning of the ophiolite took place above a top‐to‐NNE, crustal‐scale ductile shear zone, deforming existing veins and forming a cleavage in clay‐rich layers in early Campanian times. Ongoing extension occurred along normal‐ to oblique‐slip faults, forming horst‐graben structures and a precursor of the Jebel Akhdar dome (Campanian to Maastrichtian). This was followed by NE‐SW oriented ductile shortening and the formation of the Jebel Akhdar dome, deforming the earlier structures. Thereafter, exhumation was associated with low‐angle normal faults on the northern flank of the anticline. We correlate the top‐to‐NNE crustal‐scale shear zone with a similar structure in the Saih Hatat window to develop a unified model of the tectonic evolution of the Oman Mountains.