bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of the Point-of-Care Key Evidence Tool (POCKET): a checklist for multi-dimensional evidence generation in point-of-care tests
Authors: Huddy Jeremy R. , Ni Melody , Misra Shivani , Mavroveli Stella , Barlow James , Hanna George B. 
Published: November 2018

Abstract

Background
This study aimed to develop the Point-of-Care Key Evidence Tool (POCKET); a multi-dimensional checklist to guide the evaluation of point-of-care tests (POCTs) incorporating validity, utility, usability, cost-effectiveness and patient experience. The motivation for this was to improve the efficiency of evidence generation in POCTs and reduce the lead-time for the adoption of novel POCTs.

Methods
A mixed qualitative and quantitative approach was applied. Following a literature search, a three round Delphi process was undertaken incorporating a semi-structured interview study and two questionnaire rounds. Participants included clinicians, laboratory personnel, commissioners, regulators (including members of National Institute for Health and Care Excellence [NICE] committees), patients, industry representatives and methodologists. Qualitative data were analysed based on grounded theory. The final tool was revised at an expert stakeholder workshop.

Results
Forty-three participants were interviewed within the semi-structured interview study, 32 participated in the questionnaire rounds and nine stakeholders attended the expert workshop. The final version of the POCKET checklist contains 65 different evidence requirements grouped into seven themes. Face validity, content validity and usability has been demonstrated. There exists a shortfall in the evidence that industry and research methodologists believe should be generated regarding POCTs and what is actually required by policy and decision makers to promote implementation into current healthcare pathways.

Conclusions
This study has led to the development of POCKET, a checklist for evidence generation and synthesis in POCTs. This aims to guide industry and researchers to the evidence that is required by decision makers to facilitate POCT adoption so that the benefits they can bring to patients can be effectively realised.
On a duality theorem of Schneider–Stuhler
Authors: Nori Madhav , Prasad Dipendra 
Published: November 2018

Abstract
We extend a duality theorem of Schneider and Stuhler
about

Ext
G
i

⁢

[

π
1

,

π
2

]

{{\rm Ext}_{G}^{i}[\pi_{1},\pi_{2}]}

proved in [11]
for smooth representations of a p-adic group G
with central characters to all smooth representations
assuming their result for only irreducible representations by generalities in
homological algebra.
Inverse nodal problem for p−Laplacian Bessel equation with polynomially dependent spectral parameter
Authors: Yilmaz Emrah , Hamadamen Mudhafar , Gulsen Tuba 
Published: November 2018

Abstract
In this study, solution of inverse nodal problem for p−Laplacian Bessel equation is extended to the case that boundary condition depends on polynomial eigenparameter. To find spectral datas as eigenvalues and nodal parameters of this problem, we used a modified Prüfer substitution. Then, reconstruction formula of the potential functions is also obtained by using nodal lenghts. However, this method is similar to used in [Koyunbakan H., Inverse nodal problem for p−Laplacian energy-dependent Sturm-Liouville equation, Bound. Value Probl., 2013, 2013:272, 1-8], our results are more general.
The crystal structure of 1,2-dimethyl-3,4-dinitrobenzene, C8H8N2O4
Authors: Fanfan Shen , Shaomin Xue , Jianlong Wang 
Published: November 2018

Abstract
C8H8N2O4, monoclinic, P21/c (no. 14), a = 7.8936(7) Å, b = 14.4210(13) Å, c = 16.0109(15) Å, V = 1799.5(3) Å3, Z = 8, R
gt(F) = 0.0590, wR
ref(F
2) = 0.1293, T = 173(2) K.
Congenital Heart Defects Coexisting with Omphalocele - the Important Prognostic Factor
Authors: Sokołowski Łukasz , Respondek-Liberska Maria , Krekora Michał , Płużańska Joanna , Słodki Maciej 
Published: November 2018

Abstract
Introduction: The aim of this study was to evaluate the following parameters of fetuses and neonates with omphalocele: the prevalence of coexisting congenital heart defects (CHD), abnormalities in heart function and the impact of coexisting CHD on fetal and neonatal survival. Material and methods: The study group consisted of 69 fetuses with omphalocele diagnosed and monitored at the Department of Prenatal Cardiology in our Institute in the years 2007-2017. The retrospective analisis of patients' data was performed. For statistical analysis we used Chi-square test, t-Student test and U Mann-Whitney test.. Results: In the studied group omphalocele was an isolated defect in 31.9% of the cases (22/69), in 68.1% (47/69) coexisting defects were present, in 49.3% (34/69) the coexisting defect was CHD. The most common CHD coexisting with omphalocele were ventricular septal defect (VSD), double outlet right ventricle (DORV) and atrio-ventricular septal defect (AVSD). Abnormalities of heart function were present in 43.5% (30/69) of fetuses with omphalocele: 23.5% (8/34) with normal heart anatomy and in 62.9% (22/35) with CHD. Statistically significant differences between the group with normal heart anatomy and the group with CHD regarded: Cardiovascular Profile Score (CVPS) (median 10 points vs median 9 points, U Mann-Whitney test p=0.034), neonatal birth weight(mean 3253 g vs median 2700 g, U Mann-Whitney test p=0.003), Apgar score (median 8 vs median 7, U Mann-Whitney test p=0.038) and survival rate until discharge from hospital (85% vs 52.9%, Chi-square test p=0.034). The comparison of data from 2007-2017 with data obtained from similar analysis performed in our center in 1999-2006, revealed significant improvement in the early detection of omphalocele (median 14.5 weeks of gestation vs mean 25.4 weeks of gestation), gestational age of delivery (mean 38 weeks of gestation vs mean 34 weeks of gestation) and survival rate until discharge both in neonates with normal heart anatomy and coexisting CHD (85% and 52.9% vs 70% and 23% respectively) . Conclusions: 1. The presence of coexisting CHD is an important prognostic factor in fetuses and neonates with omphalocele, so early fetal echocardiography should be performed in every case of omphalocele. 2. During the last decade (2007-2017), in contrast to years 1999-2006, we observed significant improvement in early and complete prenatal diagnosis of omphalocele. 3. We observed improvement in strategy of obstetrical management resulting in delivering neonates in a more advanced gestational age both in the group with normal heart anatomy and the group with coexisting CHD.
Jealousy 4.0? An empirical study on jealousy-related discomfort of women evoked by other women and gynoid robots
Authors: Szczuka Jessica M. , Krämer Nicole C. 
Published: November 2018

Abstract
While first empirical studies on sexual aspects of human-robot interaction mostly focus on male users’ acceptance, there is no empirical research on how females react to robotic replications of women. To empirically investigate whether robots can evoke the same kind of jealousy-related discomfort as do other women, we conducted an online study in which 848 heterosexual female participants from Germany reacted to the idea that their partner had sexual intercourse with either another woman, a human-like female-looking robot, or a machinelike female-looking robot. The results revealed dimensions in which the jealousy-related discomfort was higher for female competitors compared to the robotic ones (e.g., discomfort caused by the idea of sexual intercourse),whereas in others the robots evoked the same or higher levels of jealousy-related discomfort (e.g., discomfort caused by feelings of inadequacy, discomfort caused by shared emotional and time resources). The variance in the discomfort regarding sexual interactions between one’s partner and robotic competitors could not be explained by personal characteristics (such as self-esteem, subjective physical attractiveness) but rather by technology-related variables (e.g., negative attitude towards robots, a tendency towards anthropomorphism) and the attitude towards sexual nonexclusivity in relationships. The study provides first empirical insights into a question which is of relevance for a responsible handling of sexualized technologies.
Translation, cross-cultural adaptation, and psychometric properties of the Hausa version of the Fear-Avoidance Beliefs Questionnaire in patients with low back pain
Authors: Ibrahim Aminu A. , Akindele Mukadas O. , Kaka Bashir , Bello Bashir 
Published: November 2018

Abstract

Background and aims
The Fear-Avoidance Beliefs Questionnaire (FABQ) is the most widely used self-reported measure of fear-avoidance beliefs about work and physical activity in low back pain (LBP). However, there is no Hausa version for use in patients with LBP. This study aimed to translate, cross-culturally adapt, and test the psychometric properties of the Hausa version of the FABQ in patients with LBP.

Methods
The Hausa form of FABQ was developed using a forward-backward translation procedure according to recommended guidelines. The pre-final version of the questionnaire was pre-tested on 10 patients with acute LBP and 10 patients with chronic LBP. Psychometric testing was performed in 70 patients with acute LBP and 130 patients with chronic LBP. Reliability was assessed using internal consistency (Cronbach α) and test-retest reliability through intraclass correlation coefficient (ICC). Construct validity was assessed by exploratory factor analysis and divergent validity (Spearman rank correlation coefficient). Responsiveness was also investigated on 40 patients with chronic LBP.

Results
The Hausa version of the FABQ was successfully translated and proved to be well-understood. The internal consistency was adequate for the questionnaire (0.773) and its physical activity (0.816) and work (0.606) subscales. Test-retest reliability was excellent with an ICC value of 0.928 for the questionnaire and values of 0.901 and 0.863 for the physical activity and work subscales, respectively. Exploratory factor analysis yielded a three-factor structure in both acute and chronic LBP samples explaining 66.4% and 58.6% of the total variance, respectively. The first factor represents fear-avoidance beliefs due to work, the second factor represents fear-avoidance beliefs due to physical activity whereas the third factor represents the fear that pain aggravates due to work. Divergent validity showed moderate to weak correlation between the questionnaire and pain intensity (r=0.502), disability (r=0.415), lumbopelvic motion (r=0.00). The physical activity and work subscales weakly correlated (r=0.280). The effect size and standardized response mean were moderate to small with the work subscale having the lowest effect size (0.34) and standardized response mean (0.34) values. The MDC of the questionnaire was 5.4 points. The questionnaire had no ceiling or floor effects.

Conclusions
The FABQ was successfully translated into Hausa and cross-culturally adapted with acceptable psychometric properties similar to those of existing versions. The results suggest that the Hausa FABQ can be used to evaluate fear-avoidance beliefs about LBP in Hausa-speaking population for both clinical and research purposes.
Optimization of Trenched Film Cooling Using RSM Coupled CFD
Authors: Krishna Anand V.G. , Parammasivam K.M. 
Published: November 2018

Abstract
The trench film cooling employs film holes embedded in a slot created on the surface that requires protection from the impact of hot mainstream flow. The present investigation employs Response Surface Methodology (RSM) approach coupled with CFD analysis to develop a regression predictive model and to optimize the trench geometric and flow parameters viz., trench width (w), trench depth (d), film hole compound angle (β) and blowing ratio (M). The Area-averaged film cooling effectiveness (ȠAA) were chosen as a response factor for RSM and with trench design and flow parameters used as input factors for regression analysis. Analysis of variance (ANOVA) analysis was carried out on the regression model to identify the influence of individual parameters. Three dimensional response surfaces that relate the effect of input parameters on the response factor were analyzed. Experimental results of a case identified from the RSM matrix was found to correlate well with computational investigations. Results from the study indicate that the parameters d, β and M have considerable impact on film cooling performance of test surface with trenches.
An ionic Cd/Hg mixed-metal complex with an aminoalcohol ligand
Authors: Mardani Zahra , Kazemshoar-Duzduzani Reza , Moeini Keyvan , Darroudi Majid , Carpenter-Warren Cameron , Slawin Alexandra M.Z. , Woollins J. Derek 
Published: November 2018

AbstractA cadmium–mercury mixed-metal complex ofcis-2-((2-((2-hydroxyethyl)amino)ethyl)amino)cyclohexan-1-ol (HEAC), [Cd(HEAC)2][HgI4] (1), was prepared and identified by elemental analysis, FT-IR,1H NMR spectroscopy, and single-crystal X-ray diffraction. The X-ray analysis revealed an ionic structure for1in which the cadmium and mercury atoms have CdN4O2and HgI4environments, with distorted octahedral and tetrahedral geometries, respectively. The packing of the components in the crystal of1is supported by O–H···I hydrogen bonds, and these interactions lead to the formation of anR44${\rm{R}}_4^4$(22) motif.
Four Unique Interneuron Populations Reside in Neocortical Layer 1
Authors: Schuman Benjamin , Machold Robert P. , Hashikawa Yoshiko , Fuzik János , Fishell Gord J. , Rudy Bernardo 
Published: November 2018

Sensory perception depends on neocortical computations that contextually adjust sensory signals in different internal and environmental contexts. Neocortical layer 1 (L1) is the main target of cortical and subcortical inputs that provide “top-down” information for context-dependent sensory processing. Although L1 is devoid of excitatory cells, it contains the distal “tuft” dendrites of pyramidal cells (PCs) located in deeper layers. L1 also contains a poorly characterized population of GABAergic interneurons (INs), which regulate the impact that different top-down inputs have on PCs. A poor comprehension of L1 IN subtypes and how they affect PC activity has hampered our understanding of the mechanisms that underlie contextual modulation of sensory processing. We used novel genetic strategies in male and female mice combined with electrophysiological and morphological methods to help resolve differences that were unclear when using only electrophysiological and/or morphological approaches. We discovered that L1 contains four distinct populations of INs, each with a unique molecular profile, morphology, and electrophysiology, including a previously overlooked IN population (named here “canopy cells”) representing 40% of L1 INs. In contrast to what is observed in other layers, most L1 neurons appear to be unique to the layer, highlighting the specialized character of the signal processing that takes place in L1. This new understanding of INs in L1, as well as the application of genetic methods based on the markers described here, will enable investigation of the cellular and circuit mechanisms of top-down processing in L1 with unprecedented detail.SIGNIFICANCE STATEMENTNeocortical layer 1 (L1) is the main target of corticocortical and subcortical projections that mediate top-down or context-dependent sensory perception. However, this unique layer is often referred to as “enigmatic” because its neuronal composition has been difficult to determine. Using a combination of genetic, electrophysiological, and morphological approaches that helped to resolve differences that were unclear when using a single approach, we were able to decipher the neuronal composition of L1. We identified markers that distinguish L1 neurons and found that the layer contains four populations of GABAergic interneurons, each with unique molecular profiles, morphologies, and electrophysiological properties. These findings provide a new framework for studying the circuit mechanisms underlying the processing of top-down inputs in neocortical L1.
Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task
Authors: Groman Stephanie M. , Massi Bart , Mathias Samuel R. , Curry Daniel W. , Lee Daeyeol , Taylor Jane R. 
Published: November 2018

Flexible decision-making in dynamic environments requires both retrospective appraisal of reinforced actions and prospective reasoning about the consequences of actions. These complementary reinforcement-learning systems can be characterized computationally with model-free and model-based algorithms, but how these processes interact at a neurobehavioral level in normal and pathological states is unknown. Here, we developed a translationally analogous multistage decision-making (MSDM) task to independently quantify model-free and model-based behavioral mechanisms in rats. We provide the first direct evidence that male rats, similar to humans, use both model-free and model-based learning when making value-based choices in the MSDM task and provide novel analytic approaches for independently quantifying these reinforcement-learning strategies. Furthermore, we report thatex vivodopamine tone in the ventral striatum and orbitofrontal cortex correlate with model-based, but not model-free, strategies, indicating that the biological mechanisms mediating decision-making in the multistage task are conserved in rats and humans. This new multistage task provides a unique behavioral platform for conducting systems-level analyses of decision-making in normal and pathological states.SIGNIFICANCE STATEMENTDecision-making is influenced by both a retrospective “model-free” system and a prospective “model-based” system in humans, but the biobehavioral mechanisms mediating these learning systems in normal and disease states are unknown. Here, we describe a translationally analogous multistage decision-making task to provide a behavioral platform for conducting neuroscience studies of decision-making in rats. We provide the first evidence that choice behavior in rats is influenced by model-free and model-based systems and demonstrate that model-based, but not model-free, learning is associated with corticostriatal dopamine tone. This novel behavioral paradigm has the potential to yield critical insights into the mechanisms mediating decision-making alterations in mental disorders.
Epidermal Remodeling in Caenorhabditis elegans Dauers Requires the Nidogen Domain Protein DEX-1
Authors: Flatt Kristen M , Beshers Caroline , Unal Cagla , Cohen Jennifer D , Sundaram Meera V , Schroeder Nathan E 
Published: November 2018

Abstract
Phenotypic plasticity is a critical component of an organism’s ability to thrive in a changing environment. The free-living nematode Caenorhabditis elegans adapts to unfavorable environmental conditions by pausing reproductive development and entering a stress-resistant larval stage known as dauer. The transition into dauer is marked by vast morphological changes, including remodeling of epidermis, neurons, and muscle. Although many of these dauer-specific traits have been described, the molecular basis of dauer-specific remodeling is still poorly understood. Here we show that the nidogen domain-containing protein DEX-1 facilitates stage-specific tissue remodeling during dauer morphogenesis. DEX-1 was previously shown to regulate sensory dendrite formation during embryogenesis. We find that DEX-1 is also required for proper remodeling of the stem cell-like epidermal seam cells. dex-1 mutant dauers lack distinct lateral cuticular alae during dauer and have increased sensitivity to sodium dodecyl sulfate. Furthermore, we find that DEX-1 is required for proper dauer mobility. We show that DEX-1 is secreted from the seam cells during dauer, but acts locally in a cell-autonomous manner. We find that dex-1 expression during dauer is regulated through DAF-16/FOXO–mediated transcriptional activation. Finally, we show that dex-1 acts with a family of zona pellucida domain-encoding genes to regulate dauer-specific epidermal remodeling. Taken together, our data indicate that DEX-1 is an extracellular matrix component that plays a central role in C. elegans epidermal remodeling during dauer.
Online Family Problem-solving Treatment for Pediatric Traumatic Brain Injury
Authors: Wade Shari L. , Kaizar Eloise E. , Narad Megan , Zang Huaiyu , Kurowski Brad G. , Yeates Keith Owen , Taylor H. Gerry , Zhang Nanhua 
Published: November 2018

BACKGROUND AND OBJECTIVES:
To determine whether online family problem-solving treatment (OFPST) is more effective in improving behavioral outcomes after pediatric traumatic brain injury with increasing time since injury.

METHODS:
This was an individual participant data meta-analysis of outcome data from 5 randomized controlled trials of OFPST conducted between 2003 and 2016. We included 359 children ages 5 to 18 years who were hospitalized for moderate-to-severe traumatic brain injury 1 to 24 months earlier. Outcomes, assessed pre- and posttreatment, included parent-reported measures of externalizing, internalizing, and executive function behaviors and social competence.

RESULTS:
Participants included 231 boys and 128 girls with an average age at injury of 13.6 years. Time since injury and age at injury moderated OFPST efficacy. For earlier ages and short time since injury, control participants demonstrated better externalizing problem scores than those receiving OFPST (Cohen’s d = 0.44; P = .008; n = 295), whereas at older ages and longer time since injury, children receiving OFPST had better scores (Cohen’s d = −0.60; P = .002). Children receiving OFPST were rated as having better executive functioning relative to control participants at a later age at injury, with greater effects seen at longer (Cohen’s d = −0.66; P = .009; n = 298) than shorter (Cohen’s d = −0. 28; P = .028) time since injury.

CONCLUSIONS:
OFPST may be more beneficial for older children and when begun after the initial months postinjury. With these findings, we shed light on the optimal application of family problem-solving treatments within the first 2 years after injury.
CAUSAS QUE DETERMINAN LAS DIFICULTADES DE LA INCORPORACIÓN DE LAS TIC EN LAS AULAS DE CLASES - Causes that determine the difficulties in the onboarding process of ICT in classrooms
Authors: Sierra Llorente José Gregorio , Palmezano Córdoba Yenerys Areola , Romero Mora Boris Sandy 
Published: November 2018

Las dificultades presentadas por los docentes en implementar las TIC, en el proceso de enseñanza y de aprendizaje en las aulas de clases de las instituciones educativas de la ciudad de Riohacha – La Guajira, han transformado la forma de educar, requiriendo el desarrollo profesional del profesor en un entorno tecnológico que facilite la creación de nuevos ambientes educativos mediante el uso de estrategias pedagógicas en las aulas de las instituciones educativa. El propósito del presente artículo fue analizar los factores que determinan las dificultades de la incorporación de las TIC en las aulas de clases. El sustento teórico estuvo respaldado en varios autores como Riveros y Mendoza, (2008), Monsalve (2015), Touriñán (2007), UNESCO (2013), Coll (2007), entre otros. Es un estudio de tipo descriptivo, con diseño no experimental y de campo, se utilizó la técnica de la encuesta personal, trabajo de campo y observaciones dentro de las instalaciones educativas. Llegándose a la conclusión que se requieren de unos espacios físicos adecuados y los equipos tecnológico actuales, no son suficiente para la demanda de las exigencias de los docentes y estudiantes, no existen recursos económicos suficientes para adquisición, mantenimiento, para la capacitación continua y permanente en TIC, lo cual hace que muchos docentes se rehúsen a usar las nuevas tecnologías educativas.