bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRIPAK, a highly conserved signaling complex, controls multiple eukaryotic cellular and developmental processes and is linked with human diseases
Authors: Kück Ulrich , Radchenko Daria , Teichert Ines 
Published: May 2019

Abstract
The striatin-interacting phosphatases and kinases (STRIPAK) complex is evolutionary highly conserved and has been structurally and functionally described in diverse lower and higher eukaryotes. In recent years, this complex has been biochemically characterized better and further analyses in different model systems have shown that it is also involved in numerous cellular and developmental processes in eukaryotic organisms. Further recent results have shown that the STRIPAK complex functions as a macromolecular assembly communicating through physical interaction with other conserved signaling protein complexes to constitute larger dynamic protein networks. Here, we will provide a comprehensive and up-to-date overview of the architecture, function and regulation of the STRIPAK complex and discuss key issues and future perspectives, linked with human diseases, which may form the basis of further research endeavors in this area. In particular, the investigation of bi-directional interactions between STRIPAK and other signaling pathways should elucidate upstream regulators and downstream targets as fundamental parts of a complex cellular network.
Economic Assessment of Pig Meat Processing and Cutting Production by Simulation
Authors: Plà-Aragonés Lluís M. , Pagès-Bernaus Adela , Nadal-Roig Esteve , Mateo-Fornés Jordi , Tarrafeta Pedro , Mendioroz Daniel , Pérez-Cànovas Lorea , López-Nogales Sandy 
Published: May 2019

Abstract
This paper presents the development and adoption of a discrete event simulation model of a pig meat-packing plant located in Navarre (Spain). The simulation model was developed to represent all the tasks and pig meat cuts production performed in the plant and implemented in ExtendSim™ 9.2. The development was incremental as the whole model was made of different sub-models focused in different products as for example ham, ribbon or sirloin. The main utility of the proposed model was the economic assessment of pig meat processing and cutting production. Pietrain breed presented more homogeneity and a better performance than Large White breed at equal price of the same products. In addition, even the ham is the most important cut, the loin and the bacon showed the best relative economic value with 52–53 % and 44–45 %, respectively, depending on the breed.
A relational account of communication on the basis of slips of the tongue
Authors: Gil José María 
Published: May 2019

AbstractThey are a good deal more than amusing (or embarrassing) errors of speech. The collection and analysis of such errors provides important clues to how speech is organized in the nervous system.Victoria A. Fromkin (1973: 110)Also, most current linguistics fails to consider various kinds of anomalous data which actually reveal very important information about the structure of the mental system which underlies our linguistic abilities, including slips of the tongue and unintentional puns.Sydney M. Lamb (1999: 9)AbstractThe socio-cognitive approach to pragmatics [SCA] is based on two fundamental hypotheses: (1) speaker and hearer are equal participants in the communicative process, (2) communication is the result of the interplay of intention and attention, as this interplay is motivated by the individuals’ private socio-cultural backgrounds. In this paper, I aim at showing that relational network theory (which has been mainly developed by the American neurolinguist Sydney M. Lamb) allow us to account not only for aspects corresponding to intention or attention, but also for “smooth communication” and “bumpy communication” (being the latter the dimension which includes unintended meanings). Four actual slips of the tongue will be relevant examples thanks to which it can be recognized how cooperation and intention are in a highly complex interaction together with the substantial elements of the individual traits: attention, private experience, egocentrism, and salience. Within this context, the relational account is epistemologically crucial. Firstly, it allows us to represent the neurocognitive structures that enable a person to produce or understand utterances. Secondly, it helps us to suggest that canonical pragmatics (like Speech Acts Theory, Gricean Pragmatics, Relevance Theory) cannot even consider actual and relevant phenomena like slips of the tongue, because they focus on cooperative intention and they neglect (or discard) egocentric attention.
Design and Evaluation of Outlier Detection Based on Semantic Condensed Nearest Neighbor
Authors: Batchanaboyina M. Rao , Devarakonda Nagaraju 
Published: May 2019

Abstract
Social media contain abundant information about the events or news occurring all over the world. Social media growth has a greater impact on various domains like marketing, e-commerce, health care, e-governance, and politics, etc. Currently, Twitter was developed as one of the social media platforms, and now, it is one of the most popular social media platforms. There are 1 billion user’s profiles and millions of active users, who post tweets daily. In this research, buzz detection in social media was carried out by the semantic approach using the condensed nearest neighbor (SACNN). The Twitter and Tom’s Hardware data are stored in the UC Irvine Machine Learning Repository, and this dataset is used in this research for outlier detection. The min–max normalization technique is applied to the social media dataset, and additionally, missing values were replaced by the normalized value. The condensed nearest neighbor (CNN) is used for semantic analysis of the database, and based on the optimized value provided by the proposed method, the threshold is calculated. The threshold value is used to classify buzz and non-buzz discussions in the social media database. The result showed that the SACNN achieved 99% of accuracy, and relative error is less than the existing methods.
Carbonated beverage consumption is associated with lower C-peptide in adolescents
Authors: Ye Shengkai , Chen Haiying , Ren Xia , Wen Jie , Du Ying , Li Xue , Zhang Ru , Yu Li , Zhang Biying , Du Delian , Sun Feifan 
Published: May 2019

Abstract

Background
Too much consumption of carbonated beverages increases the risk of diabetes. Insulin deficiency and the body’s decreased sensitivity to insulin cause diabetes. C-peptide can assess a person’s own insulin secretion. The decrease of C-peptide is closely related to the occurrence of diabetes and its chronic complications. The present study assessed the effect of carbonated beverages on C-peptide in adolescents and analyzed the correlation between C-peptide and the drinking index (DI).

Methods
The subjects investigated including 463 adolescents were divided into a carbonated beverages group, a non-carbonated beverages group and a control group. The general demographic characteristics, beverage consumption status, physical activity and family history of hypertension and diabetes were interviewed with a questionnaire designed by us. All the subjects maintained their original lifestyle and received the oral glucose tolerance test. Various biochemical indicators and C-peptides were detected in these three groups. The data were analyzed by statistical analysis, and multivariate logistic regression analysis was used to examine the risk factors related to C-peptide.

Results
Blood glucose, blood lipid, liver function and renal function had no statistically significant difference among the three groups. C-peptide levels were lower in the carbonated beverages group and the non-carbonated beverages group than in the control group. Compared to the non-carbonated beverages group, there was a significant decrease in C-peptide levels in the carbonated beverages group. Logistic analysis demonstrated that DI was negatively correlated with C-peptide levels when the physical activity was adjusted. The odds ratio (OR) (OR = 2.540, 95% confidence interval [CI] 1.121–5.752) value difference was statistically significant at a stratification level of DI ≥ 6.

Conclusions
The C-peptide of adolescents was affected by the long-term consumption of beverages, and the effect of carbonated beverages was even more obvious. DI ≥ 6 bottle-years was a risk factor for diabetes, and we can constitute prevention and control measures accordingly so as to reduce the incidence of diabetes.
Non-invasive assessment of aortic stiffness and blood pressure in young Turner syndrome patients
Authors: Fox Danya A. , Kang Kristopher T. , Potts James E. , Bradley Timothy J. , Stewart Laura L. , Dionne Janis M. , Sandor George G.S. 
Published: May 2019

AbstractBackgroundFemales with Turner syndrome (TS) carry an elevated risk of aortic dissection. The objective of the study was to assess the biophysical properties of the aorta and ambulatory blood pressure (BP) in females with TS and compare these findings to those in healthy female age-matched controls.MethodsThis was a prospective cohort study including subjects aged 8–25 years. Utilizing two-dimensional (2D) echocardiography and Doppler, proximal aortic dimensions were measured and biophysical properties of the aorta were calculated including pulse wave velocity (PWV), arterial pressure-strain elastic modulus and stiffness index. Resting BP was measured and ambulatory blood pressure monitoring (ABPM) was performed.ResultsOf 23 TS patients and 46 controls (median age 16.3 years), aortic annulus, sinus of Valsalva and sinotubular (ST) junction diameters, as well as left ventricular (LV) mass, were significantly greater in TS patients compared with controls when scaled for height2.7, but not for body surface area (BSA), although ascending aorta diameter was greater when scaled for both. Median PWV was faster in TS patients compared to controls (451 vs. 360 cm/s) while arterial pressure-strain elastic modulus and stiffness index were similar. Resting BP was abnormal in seven out of 22 patients and ABPM was abnormal in 16 out of 21 patients.ConclusionsYoung patients with TS had dilated proximal aortas when scaled for height2.7and stiffer aortas when compared with healthy female age-matched controls. Moreover, resting BP underdiagnosed pre-hypertension and hypertension compared to ABPM. These findings are consistent with the presence of a primary aortopathy in TS.
Utilizing health information technology to improve the recognition and management of life-threatening adrenal crisis in the pediatric emergency department: medical alert identification in the 21st century
Authors: Halpin Kelsee L. , Paprocki Emily L. , McDonough Ryan J. 
Published: May 2019

AbstractBackgroundMany barriers exist to the appropriate recognition and management of life-threatening adrenal crisis in the emergency department (ED). Clinical decision support (CDS) is a health information technology (IT) component that provides useful information to providers as healthcare is being delivered. We hypothesized that CDS incorporated into the electronic health record (EHR) could improve the recognition and management of adrenal crisis within the pediatric ED.MethodsWe retrospectively analyzed the impact of electronic CDS on the management of patients with known adrenal insufficiency (AI) presenting to two pediatric ED locations over a 19-month period with symptoms suggestive of adrenal crisis. Outcome variables assessed included the frequency of hydrocortisone (HC) administration, appropriateness of HC dosing, and timing to HC order placement and administration.ResultsA total of 145 encounters were reviewed. When the electronic CDS was in place at the time of the ED visit, patients were nearly 3 times as likely to receive HC (p = 0.002). Among those patients who received HC, the presence of the CDS increased the likelihood of an appropriate 50-mg/m2dose of HC being given from 20 to 53% (p = 0.02). However, the CDS did not significantly reduce the time from ED arrival to HC order placement (p = 0.36) or administration (p = 0.59).ConclusionsThe use of innovative health IT strategies, such as the electronic CDS, can improve the recognition and management of adrenal crisis among patients with AI presenting to the pediatric ED.
Why Monday is notin front ofTuesday: On the uses of English and Finnish front adpositions in sequence metaphors of time
Authors: Huumo Tuomas 
Published: May 2019

AbstractI analyze English and Finnishfrontadpositions commonly used insequencemetaphors of time (The days ahead of Christmas are busy). Asequencemetaphor represents the order of temporal entities as their different positions on a path along which they are moving, a temporally earlier entity being ‘ahead of’ a later one, i.e. further advanced in the direction of motion. In English, the motion-relatedfrontprepositionahead ofis conventional insequencemetaphors, as opposed toin front of, which is used only occasionally and often results in ill-formedness (*Monday is in front of Tuesday). In Finnish, the dedicated two-mover adpositionedellä‘ahead of [two-mover]’ is conventional insequencemetaphors, while the generalfrontadpositionedessäis not. Based on an analysis of these adpositions in different scenarios of spatial motion, I argue that the adpositions common insequencemetaphors (ahead of, edellä) evoke a motion frame of reference (motion FoR). In the motion FoR,frontis adjacent to the direction where the moving Ground (the entity designated by the complement of the adposition) is headed. In contrast, adpositions that bear a strong association with the standard (intrinsic or relative) FoRs (in front ofandedessä) are less felicitous insequencemetaphors. Together, the two languages demonstrate how a metaphorical motion scenario in asequencemetaphor is grammatically coded as a stable, unchanging array, where both participants are steadily moving in the same direction.
Radiochlorine: an underutilized halogen tool
Authors: Lapi Suzanne E. , Engle Jonathan W. 
Published: May 2019

Abstract
Halogen radioisotopes have a variety of physical half-lives which are suitable for probing a wide variety of pharmacokinetic processes. Compared with other radiohalogens, relatively little work has been done with radiochlorine. However, high specific activity radioisotopes of chlorine are available from low energy cyclotron production in quantities suitable for positron emission tomography (PET) and fundamental research. In particular, the sole radioisotope of chlorine which may be used for PET imaging, 34mCl, has achieved a state of development that permits imaging in clinical settings though sparse research effort has been focused on this isotope over the last 40 years. Additionally, the other longer-lived radioisotopes of chlorine will likely continue to show utility for more traditional radiotracer studies and chemistry development.
Combining gene expression data and prior knowledge for inferring gene regulatory networks via Bayesian networks using structural restrictions
Authors: de Campos Luis M. , Cano Andrés , Castellano Javier G. , Moral Serafín 
Published: May 2019

Abstract
Gene Regulatory Networks (GRNs) are known as the most adequate instrument to provide a clear insight and understanding of the cellular systems. One of the most successful techniques to reconstruct GRNs using gene expression data is Bayesian networks (BN) which have proven to be an ideal approach for heterogeneous data integration in the learning process. Nevertheless, the incorporation of prior knowledge has been achieved by using prior beliefs or by using networks as a starting point in the search process. In this work, the utilization of different kinds of structural restrictions within algorithms for learning BNs from gene expression data is considered. These restrictions will codify prior knowledge, in such a way that a BN should satisfy them. Therefore, one aim of this work is to make a detailed review on the use of prior knowledge and gene expression data to inferring GRNs from BNs, but the major purpose in this paper is to research whether the structural learning algorithms for BNs from expression data can achieve better outcomes exploiting this prior knowledge with the use of structural restrictions. In the experimental study, it is shown that this new way to incorporate prior knowledge leads us to achieve better reverse-engineered networks.
Testing for cointegration with threshold adjustment in the presence of structural breaks
Authors: Schweikert Karsten 
Published: May 2019

AbstractIn this paper, we develop new threshold cointegration tests with SETAR and MTAR adjustment allowing for the presence of structural breaks in the equilibrium equation. We propose a simple procedure to simultaneously estimate the previously unknown breakpoint and test the null hypothesis of no cointegration. Thereby, we extend the well-known residual-based cointegration test with regime shift introduced by (Gregory, A. W., and B. E. Hansen. 1996a. “Residual-based Tests for Cointegration in Models with Regime Shifts.” Journal of Econometrics 70: 99–126) to include forms of nonlinear adjustment. We derive the asymptotic distribution of the test statistics and demonstrate the finite-sample performance of the tests in a series of Monte Carlo experiments. We find a substantial decrease of power of the conventional threshold cointegration tests caused by a shift in the slope coefficient of the equilibrium equation. The proposed tests perform superior in these situations. An application to the “rockets and feathers” hypothesis of price adjustment in the US gasoline market provides empirical support for this methodology.
Shock Wave Kinematics in a Relaxing Gas with Dust Particles
Authors: Mehla Sonu , Jena J. 
Published: May 2019

Abstract
In this article, we considered the evolutionary behaviour of one-dimensional shock waves propagating through a relaxing gas with dust particles in a duct with spatially varying cross section. We adopted the procedure based on the kinematics of a one-dimensional motion to derive an infinite hierarchy of transport equations, which describe the evolutionary behaviour of shock of arbitrary strength propagating through the medium. The first three truncation approximations are considered, and the results are compared with existing results in the absence of relaxation and dust particles. The effects of dust particles and relaxation are studied using numerical computations. The results are depicted for different values of dust and relaxation parameters.
Laboratory Investigation of Ultra-High–Performance Fiber-Reinforced Concrete Modified with Nanomaterials
Authors: Zeinolabedini Afsaneh , Tanzadeh Javad , Mamodan Mitra Talebi 
Published: May 2019

Abstract
High-performance concrete with fibers and nanomaterials possesses mechanical properties that are significantly different from normal-strength concrete materials. This article presents the laboratory investigation carried out to study the behavior of ultra-high–performance fiber-reinforced concrete modified with nanomaterials. The aim of this study was to use an optimum composite of nanoalumina, nanolime, nanosilica, and polypropylene fibers to improve the mechanical properties of the concrete. The results of compression and flexure tests showed that the addition of nanolime, nanosilica, and nanoalumina with the optimum mixing ratio could be a good alternative to increasing the amount of cement to increase the compressive strength of the concrete. Adding an extra amount of nanolime in compressive strength should be done cautiously, but the effect of nanosilica is far less sensitive. The results showed that using 30-kg/m3 nanosilica, 5-kg/m3 nanolime, and 0.75-kg/m3 fiber produced the best result. In the test of concrete durability in acidic and noncorrosive environments, these amounts showed higher acid resistance. Increasing the amount of nanolime and nanosilica alone increases the flexural strength, while increasing the amount of nanomaterials or fiber will reduce it. The effect of increasing the amount of cement on the increase in flexural strength is much less than increasing the amount of nanomaterials. Also, the relationship between flexural strength and compressive strength was estimated for laboratory tests in fiber-reinforced concrete modified with nanomaterials compared with conventional ones. This study has shown that the American Concrete Institute experimental relationship between compressive strength and flexural strength is not consistent with this type of ultra-high–performance concrete.
Effects of interleukin-1 antagonism on cortisol levels in individuals with obesity: a randomized clinical trial
Authors: Ebrahimi Fahim , Urwyler Sandrine A , Schuetz Philipp , Mueller Beat , Bernasconi Luca , Neyer Peter , Donath Marc Y , Christ-Crain Mirjam 
Published: May 2019

Background
Anti-inflammatory treatment with interleukin-1 (IL-1) antagonism decreases both cortisol and adrenocorticotropin hormone (ACTH) levels in individuals with obesity in short term. However, it remains unknown whether these effects persist upon prolonged treatment.

Methods
In this double-blind, parallel-group trial involving patients with features of the metabolic syndrome, 33 patients were randomly assigned to receive 100 mg of anakinra (recombinant human IL-1 receptor antagonist) subcutaneously twice-daily and 34 patients to receive placebo for 4 weeks. For this analysis, change in cortisol and ACTH levels from baseline to 4 weeks were predefined end points of the trial.

Results
The mean age was 54 years, baseline cortisol levels were 314 nmol/L (IQR 241–385) and C-reactive protein (CRP) levels were 3.4 mg/L (IQR 1.7–4.8). Treatment with anakinra led to a significant decrease in cortisol levels at day 1 when compared to placebo with an adjusted between-group difference of 28 nmol/L (95% CI, −7 to −43; P = 0.03). After 4 weeks, the cortisol-lowering effect of anakinra was attenuated and overall was statistically not significant (P = 0.72). Injection-site reactions occurred in 21 patients receiving anakinra and were associated with higher CRP and cortisol levels.

Conclusions
IL-1 antagonism decreases cortisol levels in male patients with obesity and chronic low-grade inflammation on the short term. After prolonged treatment, this effect is attenuated, probably due to injection-site reactions (ClinicalTrials.gov, NCT02672592).