bluuebunny/crossref_metadata_2025_split huggingface dataset:
Latest developments in biomaterial interfaces and drug delivery: challenges, innovations, and future outlook
Authors: Patel Saraswati , Salaman Samsi D. , Kapoor Devesh U. , Yadav Richa , Sharma Swapnil 
Published: November 2024

Abstract
An ideal drug carrier system should demonstrate optimal payload and release characteristics, thereby ensuring prolonged therapeutic index while minimizing adverse effects. The field of drug delivery has undergone significant advancements, particularly within the last two decades, owing to the revolutionary impact of biomaterials. The use of biomaterials presents significant due to their biocompatibility and biodegradability, which must be addressed in order to achieve effective drug delivery. The properties of the biomaterial and its interface are primarily influenced by their physicochemical attributes, physiological barriers, cellular trafficking, and immunomodulatory effects. By attuning these barriers, regulating the physicochemical properties, and masking the immune system’s response, the bio interface can be effectively modulated, leading to the development of innovative supramolecular structures with enhanced effectiveness. With a comprehensive understanding of these technologies, there is a growing demand for repurposing existing drugs for new therapeutic indications within this space. This review aims to provide a substantial body of evidence showcasing the productiveness of biomaterials and their interface in drug delivery, as well as methods for mitigating and modulating barriers and physicochemical properties along with an examination of future prospects in this field.
A methodological framework for sustainable housing for displaced populations
Authors: Gueroui Asma , Halada Miklos 
Published: November 2024

AbstractThis research highlights the role of sustainability aspects focusing on socio-cultural parameters and environmental performance in designing more comfortable and sustainable shelters. Following a two-mixed method approach, on the one hand, a comparative analysis is presented of IKEA Better Shelter, Rwandan Mud-Brick, and Nepali shelters by examining the cultural integration into their design (traditional layouts and shared spaces), their adaptability, and their environmental performance. On the other hand, a qualitative survey determines the level of satisfaction regarding space, comfort, social interaction, and cultural fit among residents. The results show that traditional building methods with the use of local materials, offer high privacy levels, excellent thermal and acoustics comfort, good cultural appropriateness and minimal environmental impact.
Improving Management of Oil and Gas Assets Through Derivatives
Authors: Stibolt Robert D. 
Published: November 2024

Management
Summary
As markets for futures, swaps, and options have grown and matured in the oil and gas industry, the question of how companies should make use of such financial derivatives naturally arises. The simplest models of risk vs. return in modem finance theory are based on a world in which the costs of external and internal financing are the same and all risk is either systematic or can be diversified by shareholders. In this simplified world, derivatives must be viewed as purely speculative instruments that can add nothing to shareholder value. However, in the real world of financial distress, imperfect information, and misaligned management/shareholder risk attitudes, the use of these instruments can add significant value. This paper explores the sources of this potential for value creation, including a look at improving organizational alignment, information consistency, capital structure, and management of real assets.
Integrating Data for the Reservoir Engineer
Authors: Gochnour J. Robert 
Published: November 2024

Computer Applications
Summary
More and more companies· are moving to multidisciplinary asset teams to work cooperatively on the same reservoir management and development studies. In the past, software developed specifically for the different disciplines or players had no mechanism for sharing the results effectively. With the enhancements in technology for collecting data, its quality and quantity have increased tremendously. The thrust now is removing data barriers between the different disciplines and proprietary systems, allowing data to be shared in a timely fashion to improve accuracy and productivity. At the same time, many companies desire to preserve previous investments in software, whether it was purchased or developed internally. A project data store has been developed that allows companies to use all reservoir, petroleum engineering, fluid, and geoscience data in a variety of applications, including their own favorite software, overcoming previous integration problems and leading to improvements in reservoir modeling, reservoir management, and risk reduction. Easy access to the bank of this information on global, corporate, and project levels will equalize technology at both large and small energy producers. Managing its access and use will drive software development in the near future.
The Genomic Evaluation of Space Travel and Research (GENESTAR) Manual for Biospecimen Collection, Biobanking and Omics Data Generation from Commercial Space Missions
Authors: Krishnavajhala Aparna , Gingras Marie-Claude , Urquieta Emmanuel , Chao Hsu , Bandaranaike Dilrukshi , Chen Yi , Bhamidipati Sravya , Korchina Viktoriya , Griffin S. Michelle , Masternak Michal , Moreno Hannah , Mohammed Javid , Murugan Mullai , Posey Jennifer , Wu Jimmy , Muzny Donna , Gibbs Richard , Doddapaneni Harsha vardhan 
Published: November 2024

Abstract

The surge in commercial and civilian spaceflight enables for the first time, systematic and longitudinal, large-scale biospecimen collection to understand prospective effects of space travel on human health. The Genomics and Space Medicine (Space Omics) project at BCM-HGSC involves a comprehensive biospecimen collection plan from commercial/private space flight participants (SFP). Biospecimens from multiple pre-launch (leading up to quarantine period) and post-return (the day of return, R + 0 onwards) time points are collected. The diverse array of biospecimen collections include venous blood, body swabs, saliva, stool, and urine samples and their derivatives. The manuscript addresses the critical gaps thus far in the biospecimen collection process such as informed consent process and a provision for subjects to obtain custom CLIA-WGS reports. We discuss here, the biospecimens collection, processing methodologies and nucleic acids’ suitability for Omics data generation, including successful generation of 16S rRNA data that have been presented as a ‘Genomic Evaluation of Space Travel and Research (GENESTAR)’ manual. Results from Axiom-2 mission where, a total of 339 biospecimens were collected using this manual, at two different sites, showed that 98% of the accessed blood samples and 91.6% of the non-blood samples passed the QC requirements for Omics assays, underscoring the reliability and effectiveness of the GENESTAR manual. Also for the for the first time, to support Space Omics studies, details of a data dictionary and a LIMS enabled biobank, are provided.
Exploring Salt Stress Tolerance in Horsegram (Macrotyloma uniflorum): Insights from Growth, Physiology and Biochemical Approaches
Authors: Singh Narayan , Maurya Vasudha , Sharma Ashutosh , Kumar Rahul 
Published: November 2024

Abstract

Soil salinity is one of the significant challenges affecting seed germination, growth, physiology, and crop productivity worldwide. Horsegram is known for its higher tolerance to stress conditions than other legumes and therefore is a potential pulse and fodder crop in salt-affected areas. During this study, 25 horsegram genotypes were screened under a controlled environment to identify salt-tolerant and sensitive genotypes based on the salt tolerance index and membership function value of 10-day-old seedlings. DH-22 and DH-29 were identified as salt-tolerant, while DH-11 and DH-12 were identified as salt-sensitive genotypes. These genotypes were further analyzed under 0, 50, 100, and 150 mM NaCl treatments to examine various growth, physiological, and biochemical parameters. The analysis revealed that the tolerant genotypes exhibited higher root and shoot length, dry and fresh weight, relative water content, chlorophyll and carotenoids content, free proline and phenolic content, and enhanced activity of antioxidant enzymes such as catalase, ascorbate peroxidase, glutathione reductase, superoxide dismutase, and guaiacol peroxidase. Further, lipid peroxidation, hydrogen peroxide content, and percent ion leakage decreased in the tolerant genotypes than in the sensitive genotypes. Additionally, the tolerant genotypes displayed less cell death and lower accumulation of H2O2 and superoxide ions in histochemical staining, which may play a vital role in cellular protection during salt stress tolerance.
Prevalence and clininco-pathological correlation of Sino- nasal malignancies in Sudan
Authors: Abdallah Ayat , Ahmed Sharfi , Ibrahim Ibrahim Gaffar , Ali Mujtaba A. 
Published: November 2024

Abstract

Background: Sinonasal malignancies are uncommon neoplasms with several histopathological subtypes. These malignancies have a poor prognosis, and because of the nonspecific nature of the symptoms, most patients are diagnosed late when the disease is already at an advanced stage. This is the first study to describe the prevalence and clinicopathological correlation of sinonasal malignancy in Sudan.
Objectives: This study aims to determine the prevalence and clinicopathological correlations of sinonasal malignancies among Sudanese patients, done in a cohort of patients in Khartoum state from September 2020 to September 2021.
Methods: This is a cross-sectional hospital-based study. All Ear, nose, and throat hospitals in Khartoum state, Sudan, were included. In the period from 01/09/2020 – 30/09/2021. Data were collected using structured interviews. Data were analyzed by statistical package for social sciences (SPSS).
Results: In Khartoum state, the study encompassed all patients diagnosed with sinonasal malignancies who willingly participated. Out of the consenting participants, 44 individuals were enrolled, with males constituting 61.4% of the cohort and females representing 38.6%. Noteworthy is the observation that 38.6% of the patients fell within the age range of 50-60 years old.
The estimated prevalence of sinonasal malignancies is 0.6 per 1000 individuals. Unilateral nasal obstruction emerged as the most frequent presentation (72.7%), followed by epistaxis in 56.8%. In terms of risk factors, 18.2% were identified as smokers, and 6.8% were woodworkers; however, a notable proportion (63.6%) did not exhibit any of the known risk factors.
Conclusion: The estimated prevalence of sinonasal malignancies is 0.6 per 1000 individuals. Nasal obstruction was identified as the most common presenting symptom, and decreased visual acuity emerged as the predominant ophthalmological symptom. Notably, there was a significant association between epistaxis and squamous cell carcinoma (SCC) in 15 patients, with a p-value of 0.005. Emphasizing the importance of early detection and timely treatment, these findings highlight the critical role they play in improving patient outcomes.
Potential Shared Neoantigens from Pan-cancer Transcript Isoforms
Authors: Techachakrit Jirapat , Malik Aijaz Ahmad , Pisitkun Trairak , Sriswa Sira 
Published: November 2024

Abstract

Background: Isoform switching in cancer is a prevalent phenomenon with significant implications for immunotherapy, as actionable neoantigens derived from these cancer-specific events would be applicable to broad categories of patients, reducing the necessity for personalized treatments.
Results: By integrating five large-scale transcriptomic datasets of cancer and normal tissues, we identified cancer-associated isoform switching events common to multiple cancer types, several of which involve genes with established mechanistic roles in oncogenesis. The presence of neoantigen-containing peptides derived from these transcripts was confirmed in broad cancer and normal tissue proteome datasets and the binding affinity of predicted neoantigens to the human leukocyte antigen (HLA) complex via molecular dynamic simulations.
Conclusion: The study presents strong evidence that isoform switching in cancer is a significant source of actionable neoantigens that have the capability to trigger an immune response. These findings suggest that isoform switching events could potentially be leveraged for broad immunotherapeutic strategies across various cancer types.
Assessing the Impact of Trauma Score, Mechanisms and Demographics on Chest Injury Outcomes
Authors: Sarbay İsmail , Öncü Kıvanç , Esme Nurullah Sait , Sarbay İbrahim 
Published: November 2024

Abstract

Aim
This study evaluated the effects of trauma mechanisms and age intervals on injury extent and prognosis in chest traumas to enhance trauma management strategies.
Background
Chest traumas are a major cause of morbidity and mortality globally, often resulting from high-energy impacts like motor vehicle accidents, falls, crushing injuries, and penetrating injuries. These can lead to various injuries, including lung contusions and rib fractures, requiring urgent medical or surgical intervention. The injury severity and mechanism, along with factors such as age and gender, influence clinical outcomes.
Methods
This was a retrospective study of 525 patients with thoracic trauma presenting to a secondary-care public hospital from May 2022 to May 2024. Demographic profiles, diagnoses, radiological findings, and surgical procedures were recorded and analyzed using Binary and Multinomial Logistic Regression and Chi-square tests.
Results
Among 525 patients, 158 were female, and 367 were male. The most common trauma etiologies were falls (58.7%) and traffic accidents (22.7%). Rib fractures were the most frequent injury (67.2%), with older patients and females at higher risk. Concomitant injuries were present in 28% of cases, mainly in traffic accidents. Intensive care was required in 12.4% of cases, especially after post-resuscitation, crush traumas, and polytrauma. The Chest Trauma Score (CTS) correlated with the hospitalization, requirement for intensive care, hemothorax, pneumothorax, and concomitant injuries.
Conclusion
The mechanism of injury and age significantly impact injury extent in chest traumas. Falls and traffic accidents increase the risk of rib fractures, while older patients are at higher risk for hemothorax and rib fractures. An increased trauma score is related to concomitant injuries and the requirement for intensive care. These findings emphasize the importance of factoring in both the type of trauma and the age in patient management to provide appropriate treatment and prevent complications.
Effect of Er:Yag Laser and Different Surface Treatment Methods on the Push out Bond Strength of Glass Fiber Post to Self Adhesive Resin Cement
Authors: Elalfy Nouran , Elbasty Reham 
Published: November 2024

Abstract

Purpose
to compare the bond strength of adhesive-based resin cement and glass fiber posts (GFP) at different root levels after exposure to Er:Yag laser irradiation compared to other conventional surface treatment procedures.
Methods
A total of 24 mandibular premolars were decoronated, root canal treatment was done, post spaces were prepared, and roots were mounted in acrylic resin blocks. Fiber posts were divided into four groups (n = 6) according to surface treatment methods: 1) silane only (control group), 2) Er:YAG laser 1.5 W + silane, 3) 30% hydrogen peroxide + silane, 4) sandblasting with 50 µm aluminum oxide particles + silane. GFP were cemented using self-adhesive resin cement. Scanning electron microscope images with 500x magnification were taken for all groups. Push-out test was performed using a universal testing machine.
Results
The difference between groups was statistically significant with laser group recorded the highest mean ± SD value of push out bond strength (5.668042 ± 1.16 MPa), followed by H2O2 group ,then the control group, meanwhile the lowest value was recorded with Sand-blasting group. The difference between the radicular regions was not statistically significant, with the middle region recorded the highest push out bond strength (4.746851 ± 0.73 MPa).
Conclusion
GFP surface treatment using an Er:yag laser is effective as it increases the retention to resin cement,while sandblasting decreases fiber post retention to resin cement. The hydrogen peroxide and the silane coupling agent give similar bond strength. The middle and apical regions of GFP have better retention to resin cement than the coronal one.
The Burden of Non-Communicable Disease and asociated factors among ART Patients in Nekemte Compressive Specialized Hospital, Western Ethiopia 2023
Authors: Benti Dugasa Garoma , Daba Debelo Diriba , Hunegna Gizew , Abdena Deressa , Etefa Alemayehu , Adugna Motuma 
Published: November 2024

Abstract

Background: Globally, Non-Communicable Diseases is a major and emerging public health problem. Comorbidity between HIV and Non-Communicable Diseases (NCDs) is an increasing issue for public health in developed and developing countries. However, there was limited literature to assess the Burden and associated factors in Ethiopia.
Objective: The study aimed to assess the Burden and associated factors among people living with HI (PLWHIV) at Nekemte Compressive Specialized Hospital in Western, Ethiopia.
Method: A Facility based cross-sectional study design was used. A total of 371 study participants were selected using systematic random sampling techniques. The study was conducted from February 01 to June, 30,2023 using structured questionnaires for data collection. Bivariable and multivariable logistic regression was used to identify associated factors then variables with a p-value <0.05 were declared to have an association with the dependent variable.
Result: The Burden of common non-communicable disease among people living with HIV was 28.57% with 95% [CI: 24-33]. Age group between 35 years and 54 years [AOR 3.75; 95% CI: 1.73–8.14] and ≥55years [AOR 6.48; 95% CI: 2.42–17.38], participants who earn moderate and higher monthly income 1000-3000 Birr [AOR 2.33; 95% CI: 1.16, 4.67] and ≥3000 birr [AOR 2.19; 95% CI: 1.10, 4.36]. The Burden of common non-communicable diseases was considerably higher among ART patients with opportunistic infections [AOR 12.83; 95%CI: 3.65, 45.01] and lower among those with a family history of hypertension [AOR: 0.145; 0.08, 0.26].
Conclusions: The Burden of common NCD among patients on ART in Nekemte Compressive Specialized Hospital was considerably high. Government policy and programmatic interventions are required, including the integration of non-communicable disease screening into HIV programs. Interventions should be customized to the patient's age and focus on raising their awareness and knowledge of moderate and high monthly income. This is needed for disparities in age groups, income levels, and the prevalence of opportunistic diseases.
Organochlorine pesticides and epigenetic alterations in brain cancer
Authors: Yousefi Fatemeh , Asadikaram Gholamreza , Karamouzian Saeid , Abolhassani Moslem , Pourghadamyari Hossein , Moazed Vahid 
Published: November 2024

Abstract

Background:
Epigenetic alterations have emerged as critical factors in the pathogenesis of brain cancer, particularly gliomas. This article explores the impact of organochlorine pesticides (OCPs) on the hypermethylation of key tumor suppressor genes, and some histone modifications in primary brain tumor (PBT) patients.
Methods:
This study involved 73 patients diagnosed with PBT and 15 non-cancerous brain tissue samples as contol . DNA extracted from tumor specimens was used to evaluate the methylation status of tumor suppressor genes, P16 and RRP22, using the methylation-specific PCR (MSP) technique and four histone marks (H4K16ac, H3K9ac, H4K20me3, and H3k4me2) to investigate by western blotting.
Results:
The results of MSP revealed the methylation of P22 and P16promoter regions and western blot analysis demonstrated significantly low levels of H3K9ac, H4K20me3, and H3K4me2 in PBT patients in comparison with the controls. The results of regression analysis revealed direct and significant correlations between serum OCPs concentration and methylation of P22 and P16. Furthermore, a direct and significant association was observed between hypomethylation of histones H3K4 and H4K20, as well as hypoacetylation of H3K9, with OCPs levels.
Conclusion:
This study revealed that epigenetic modifications play a significant role in the development of brain tumors, with OCPs identified as key contributors to these changes. Our research indicated that in patients with PBT, hypermethylation of the P22 and P16 gene and histone modifications correlates directly and significantly with the levels of OCPs found in their serum.
Oral Health Skills Framework for Pregnant Women: a Professional Consensus
Authors: TENENBAUM Annabelle , YAZDANBAKHSH Mehrnoosh , CERDAN Iris , CAILHOL Johann , DEANDRADE Vincent , MAURICE Aurélie , MARQUILLIER Thomas , MARGAT Aurore , LOMBRAIL Pierre , GAGNAYRE Rémi , RIQUET Sébastien , AZOGUI-LEVY Sylvie 
Published: November 2024

Abstract

Background
Pregnancy is a period susceptible to oral pathologies such as periodontal disease and dental caries, which have been linked to adverse pregnancy outcomes. Research shows that a child’s oral health is shaped by complex individual and collective factors and is closely tied to the health of their parents, particularly their mothers. Although oral health education interventions are offered during pregnancy follow-ups, their effectiveness is difficult to assess. This study presents a competency framework for pregnant women through oral health education programs, serving as a resource for healthcare professionals.
Methods
A three-round Delphi method assessed professional experts' opinions. A literature review generated 40 resources that informed the first-round questionnaire, structured into two sections (pregnant woman and child). Three main families of skill (preventing, monitoring caries/periodontal disease, seeking dental care) were divided into 96 contributory learning objectives, categorized by knowledge, practices, and attitudes. Experts rated the usefulness of each objective on a 5-point Likert scale, with consensus set at 70%. The expert panel comprised 21 perinatal professionals (midwives, pediatricians, gynecologists, general practitioners, dentists, pharmacists).
Results
In the first round, 59% of objectives were rated very useful. Forty objectives failed to find consensus and were reformulated for the second round. Oral hygiene achieved better consensus than nutrition-related fields of application. After three rounds, four areas still lacked consensus: the risk of preeclampsia related to periodontal disease, breastfeeding’s impact on oral health, women's search for oral health information, and saliva's protective role. A consensus-based competency framework for pregnant women's oral health education was developed centered on three key competencies: preventing oral diseases, participating in care plans, and asserting rights.
Conclusions
Reaching a consensus on women's oral health skills is essential for a cross-disciplinary approach to common prevention strategies and oral health education during the perinatal period. Further work is needed to define implementation strategies environments and identify professionals suited for delivering brief oral health interventions during pregnancy follow-ups.