bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Rare Case of Anti-VGKC Limbic Encephalitis Secondary to High-Grade Glioma
Authors: Johnson DeJarra Caprii , Kline Feldman David Edward , Marri Preethi 
Published: February 2019

AbstractParaneoplastic limbic encephalitis secondary to a glial tumor is rare, and limited reports on this occurrence have been made in the pediatric population. This case involves a 13-year-old female patient with anti-voltage gated potassium channel (anti-VGKC) limbic encephalitis secondary to a high-grade glioma (HGG) in the suprasellar region. HHGs, associated with anti-VGKC antibodies, are a rare occurrence. This case highlights the need for the inclusion of glial neoplasms in the differential diagnosis for patients presenting with symptoms associated with paraneoplastic encephalitis.
Down-regulation of FZD3 receptor suppresses growth and metastasis of human melanoma independently of canonical WNT signaling
Authors: Li Chen , Nguyen Vincent , Clark Kaitlyn N. , Zahed Tara , Sharkas Shawn , Filipp Fabian V. , Boiko Alexander D. 
Published: February 2019

Significance
In malignant melanoma, one of the most aggressive cancers, the components of the WNT pathway are frequently deregulated and have been shown to drive self-renewal and metastatic progression of melanoma cells. Identifying tumorigenic properties of key members of the WNT signaling network in the pathogenesis of melanoma represents a pivotal task in the field and underlies successful design of targeted therapeutic approaches. In the present study, we characterized Frizzled 3 receptor (FZD3) as a critical factor underlying tumorigenic properties of aggressive human melanoma. Using in vivo and in vitro tumorigenic assays, combined with functional transcriptomics analysis of FZD3 knockdown in human patient-derived cells, we determined key signaling nodes regulated by FZD3 activity during malignant transformation.
Seductive Movements in Lysistrata and Spike Lee’s Chi-Raq: Activism, Adaptation, and Immersive Theatre in Film
Authors: Klein Emily 
Published: February 2019

AbstractThis article investigates how Spike Lee’s 2015 Lysistrata adaptation, Chi-Raq, reaches beyond the screen—‘in excess’ of its medium—by using the techniques of immersive theatre to revive Aristophanes’ classical plot as well as his urgent call to citizenly collective action (McGowan, Todd. Spike Lee. Champaign, IL: University of Illinois Press, 2014). Lee’s seductive activist fairytale in rhyming verse imagines a worldwide sex strike led by Chicago’s women of colour. Like its Classical predecessor, the film both critiques and reinforces the spectacular objectification of female bodies; that tension is always in play, even as it successfully brings about a peace treaty between two warring Englewood gangs. To explore this and other socio-political tensions, Lee’s film employs many of the ‘physical, sensual and participatory’ elements that Josephine Machon understands as central to immersive performance (Machon, Josephine. Immersive Theatres: Intimacy and Immediacy in Contemporary Performance. London: Palgrave Macmillan, 2013. xv). Crucial to this immersive adaptation is Lee’s transgressive coordination of sight, touch, and sound to aptly update Lysistrata’s acts of refusal as deeply gendered and racialized calls for intimate justice. In effect, audiences learn, move, chant, yearn, and envision a better world alongside the characters in the film. As a result, the goals of Chi-Raq are achieved in ways that are both more compellingly relevant and more radical than any other contemporary Lysistrata adaptation in recent memory.
The PD-1/PD-L1 Axis in HER2+ Ductal Carcinoma In Situ (DCIS) of the Breast
Authors: Ubago Julianne M , Blanco Luis Z , Shen Tiansheng , Siziopikou Kalliopi P 
Published: February 2019

ABSTRACTObjectivesThe aims were to evaluate the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) axis in ductal carcinoma in situ (DCIS) of the breast.MethodsWe reviewed 85 pure DCIS cases treated with surgical excision at our institution, including 51 luminal A (estrogen receptor [ER] positive/human epidermal growth factor 2 [HER2] negative), 15 luminal B (ER+/HER2+), 13 HER2 (ER–/HER2+), and six basal-like (ER–/HER2–/CK5/6+). The extent and intensity of PD-1 and PD-L1 immunohistochemical staining in the tumor-infiltrating lymphocytes (TILs) and in the tumor cells were recorded.ResultsOur study found that moderate/severe inflammation around DCIS correlated with HER2 expression (20/28 HER2+ cases [71%] vs 21/57 HER2– cases [37%], P = .005). Of interest, over half of the TILs around the HER2 subtype expressed PD-L1 (7/13, 54%). In addition, about one-third of TILs around the HER2 subtype expressed PD-1 (4/13, 31%).ConclusionsThese findings suggest that immune-based therapeutic strategies may be used as a potential therapy in DCIS cases with PD-L1 overexpression, especially those of the HER2 molecular subtype.
Keynes, Kalecki and Metzler in a dynamic distribution model
Authors: Bibi Samuele 
Published: February 2019

Abstract
This paper focuses on the dynamics analysis from the ultra-short to the short period from a Post-Keynesian perspective. It is argued that the construction of both the short-run and the long-run models are based on the critical assumption of an equilibrium between aggregate demand and aggregate supply. Starting from the work by Metzler (1941. The nature and stability of inventory cycles, The Review of Economic Statistics, 113–29), the issue of equilibrium and stability is investigated inside a Keynesian–Kaleckian perspective. The suggested model analyses under which conditions the standard Kaleckian conclusions are still valid considering a disequilibrium situation. Two scenarios are simulated: one with fixed expectations as in Metzler (1941. The nature and stability of inventory cycles, The Review of Economic Statistics, 113–29) and another based on adaptive expectations and asymmetric behaviour of the wages–unemployment relation. The model questions the effective demand labour curve and suggests that an increase in real autonomous expenditures, mainly by the government, might be even more essential than what is generally considered in the Kaleckian literature, to avoid increasing unemployment a world with increasing wages.
Low-Dose Metronidazole is Associated With a Decreased Rate of Endoscopic Recurrence of Crohn’s Disease After Ileal Resection: A Retrospective Cohort Study
Authors: Glick Laura R , Sossenheimer Philip H , Ollech Jacob E , Cohen Russell D , Hyman Neil H , Hurst Roger D , Rubin David T 
Published: February 2019

Abstract

Background and Aims
Recurrence of Crohn’s disease after surgical resection and primary anastomosis is an important clinical challenge. Previous studies have demonstrated the benefit of imidazole antibiotics, but have been limited by adverse events and medication intolerance. We evaluated whether administration of low-dose metronidazole [250 mg three times per day] for 3 months reduces endoscopic postoperative recurrence rates.

Methods
We performed a retrospective cohort study of patients with Crohn’s disease who underwent ileal resection with a primary anastomosis and subsequently received care at our center. We compared the cases who received low-dose metronidazole for 3 months with control patients who did not receive this therapy. Data collected included demographics, risk factors for recurrence, and medications before and after surgery. The primary end point was the number of patients with ≥i2 [Rutgeerts] endoscopic recurrence by 12 months. Variables found to be predictive in univariate analysis at p &lt; 0.10 were introduced in the Cox model for multivariate analysis.

Results
In all, 70 patients with Crohn’s disease [35 cases and 35 controls] met inclusion criteria. Risk factors for Crohn’s recurrence were similar between groups. The number of patients with ≥i2 endoscopic recurrence within 12 months following ileal resection was significantly lower in the metronidazole group [7 of 35 patients; 20%] compared with the number in the control group [19 of 35 patients; 54.3%] [p = 0.0058]. Eight participants [22.9%] in the metronidazole group experienced adverse events, and 3 of these patients [8.6%] discontinued the therapy.

Conclusion
Low-dose metronidazole reduces endoscopic recurrence of Crohn’s disease postoperatively and is well tolerated. This intervention should be considered as a therapy option following ileocolonic resection.
Management of Biological Therapy Before Elective Inflammatory Bowel Disease Surgeries
Authors: Hansen Tawnya M , Targownik Laura E , Karimuddin Ahmer , Leung Yvette 
Published: February 2019

Abstract
Increasing uptake of biologic therapy has contributed to declining surgical rates for inflammatory bowel disease (IBD). However, a significant number of patients on biologic therapy will go on to require surgery. The literature is conflicted with regard to the preoperative management of biologic therapy before urgent or elective IBD surgery. This article reviews the available data on postoperative complications following preoperative treatment with anti-tumor necrosis factor alpha therapy, anti-integrin therapy, and anti-interleukin therapy.
The Potential Global Distribution and Voltinism of the Japanese Beetle (Coleoptera: Scarabaeidae) Under Current and Future Climates
Authors: Kistner-Thomas Erica Jean 
Published: February 2019

AbstractJapanese beetle, Popillia japonica (Newman), is a severe invasive insect pest of turf, landscapes, and horticultural crops. It has successfully colonized much of the United States and has recently established in mainland Europe. The distribution and voltinism of P. japonica will undoubtedly change as a consequence of climate change, posing additional challenges to the management of this species. To assess these challenges, a process-oriented bioclimatic niche model for P. japonica was developed to examine its potential global distribution under current (1981–2010) and projected climatic conditions (2040–2059) using one emission scenario (representative concentration pathway [RCP] 8.5) and two global climate models, ACCESS1-0 and CNRM-CM5. Under current climatic conditions, the bioclimatic niche model agreed well with all credible distribution data. Model projections indicate a strong possibility of further range expansion throughout mainland Europe under both current and future climates. In North America, projected increases in temperature would enable northward range expansion across Canada while simultaneously shifting southern range limits in the United States. In Europe, the suitable range for P. japonica would increase by 23% by midcentury, especially across portions of the United Kingdom, Ireland, and Scandinavia. Under the RCP 8.5 scenario, cumulative growing degree-days increased, thereby reducing the probability of biannual life cycles in northern latitudes where they can occur, including Hokkaido, Japan, northeastern portions of the United States, and southern Ontario, Canada. The results of this study highlight several regions of increasing and emerging risk from P. japonica that should be considered routinely in ongoing biosecurity and pest management surveys.
Temperature and precipitation, but not geographic distance, explain genetic relatedness among populations in the perennial grass Festuca rubra
Authors: Šurinová Maria , Hadincová Věroslava , Vandvik Vigdis , Münzbergová Zuzana 
Published: February 2019

AbstractAimsKnowledge of genetic structure of natural populations and its determinants may provide key insights into the ability of species to adapt to novel environments. In many genetic studies, the effects of climate could not be disentangled from the effects of geographic proximity. We aimed to understand the effects of temperature and moisture on genetic diversity of populations and separate these effects from the effects of geographic distance. We also wanted to explore the patterns of distribution of genetic diversity in the system and assess the degree of clonality within the populations. We also checked for possible genome size variation in the system.MethodsWe studied genetic variation within and among 12 populations of the dominant grass Festuca rubra distributed across a unique regional-scale climatic grid in western Norway, Europe and explored the importance of temperature, precipitation and geographic distance for the observed patterns. We also explored the distribution of genetic diversity within and among populations, identified population differentiation and estimated degree of clonality. The analyses used microsatellites as the genetic marker. The analyses were supplemented by flow cytometry of all the material.Important FindingsAll the material corresponds to hexaploid cytotype, indicating that ploidy variation does not play any role in the system. The results indicate that temperature and precipitation were better predictors of genetic relatedness of the populations than geographic distance, suggesting that temperature and precipitation may be important determinants of population differentiation. In addition, precipitation, alone and in interaction with temperature, strongly affected population genotypic diversity suggesting increased clonality towards the coldest and especially the coldest wettest climates. At the same time, individuals from the coldest and wettest climates also had the highest individual genetic diversity, suggesting that only the most heterozygous individuals survive under these harsh climates. Most of the genetic variation was distributed within populations, suggesting that most populations have sufficient genetic diversity to adapt to novel climatic conditions. The alpine populations, i.e. populations which are likely the most endangered by climate change, however, lack this potential due to the high levels of clonality as detected in our study.
An Active Duty Sailor With Worsening Headaches and Blurry Vision
Authors: Thompson Chad A , Barnes Eric 
Published: February 2019

Abstract
Headaches are a typical presentation to a military medical department or emergency room. Having a broad differential diagnosis and utilizing a thorough physical exam can assist providers in honing down the list of pathology and in identifying potentially life-threatening causes of cephalgia such as intracranial tumors. In this case, a 27-year-old man presented with progressive headaches along with vision changes for the preceding 2–3 months. On initial physical exam, he was found to have bilateral papilledema using a panoptic ophthalmoscope, confirmed after sending the patient to optometry. Neurology evaluated him and found a pineoblastoma on MRI. He underwent eventual neurosurgical debulking and radiation. The highlight of this case is the critical history components along with physical exam techniques that can assist providers in the identification of life-threatening causes of a headache. Direct ophthalmoscopy was vital in this case to encourage referral for further management. In selected studies, emergency medicine providers performed ophthalmoscopy in 14% of patients, with roughly 10% of those patients having erroneous findings. Another study showed that 13% of all cases presenting to a large academic center had fundoscopic findings that were important to the final diagnosis.
An Embedded Health Engagement Team Pilot Test
Authors: Burkett Edwin K 
Published: February 2019

Abstract

Introduction
As an innovative test of an alternative health engagement method during CONTINUING PROMISE 2011 a joint embedded health engagement team (EHET) was created and executed. EHETs may serve as US military alternatives for improved outcomes in global health engagement activities.

Materials and Methods
The EHET concept was to integrate into the host nation’s public health system to collaborate in direct patient care, contribute to comprehensive preventive health, and achieve intellectual exchange between professionals of similar disciplines.

Results
EHET resulted in greater satisfaction on behalf of the host nation and US health professionals, smaller footprint of US personnel and equipment, emphasis on host nation existing infrastructure and system, action upon needs already identified by the host nation health strategy, and optimal US military and security cooperation outcomes. Although this pilot test was a military to civilian engagement the concept is applicable for military to military engagement and across the full range of US military operations. The pilot test was well received by the host nation. Participants on both sides expressed positive feedback that EHETs should be the preferred method for health engagements.

Conclusions
Thoroughly planned and executed EHET engagements should bring greater, measurable positive effects than typical mass patient care activities. EHETs are especially suitable for longer duration or recurrent missions to build partnership, capacity, and security. EHETs should replace legacy mass care missions as the primary health engagement capability to achieve mutual goals while using US military resources on legitimate local health needs.
Impact of Fire Arms Training in a Virtual Reality Environment on Occupational Performance (Marksmanship) in a Polytrauma Population
Authors: Oliver Robert A , Cancio Jill M , Rábago Christopher A , Yancosek Kathleen E 
Published: February 2019

Abstract

Introduction
Polytrauma, to include major limb amputation, in a military population presents unique rehabilitation challenges with the overarching goal of restoring function leading to the primary question, “Is this Service Member (SM) capable of returning to duty following rehabilitation?” The US military has a vested interest in maximizing injured SMs occupational performance to allow for return to duty. The purpose of this report is to describe marksmanship (shot grouping and weapon qualification) and return to duty outcomes following a course of VRE-based firearm training in a polytrauma patient population.

Methods
The medical records, stored in the Armed Forces Health Longitudinal Technology Application (AHLTA), of all patients who received rehabilitative care at the Center for the Intrepid (CFI) to include VRE-based firearms training between 01OCT2015 and 01AUG2016 were manually reviewed for inclusion. Subjects included all adult (18 years and older) SMs (active duty at time of admission) with a diagnosis of polytrauma who had been referred to and treated (received additional services such as physical and or occupational therapy) at the CFI. Approval for this research was received from the Brooke Army Medical Center Department of Clinical Investigation Office of the Institutional Review Board.

Results
Medical records of 30 SMs with a polytrauma diagnosis met the inclusion criteria. Mean shot group sizes for the M9 and M4 weapon decreased between initial and post training time points for the M9 zero (p = 0.009) and M4 zero (p = 0.020). There was no significant difference between initial and post training time points at the other shooting distances with either weapon. There was an 89% qualification rate for both the M9 (n = 18) and M4 (n = 19) weapons for those who attempted qualification; 43% of the population (n = 13) did not attempt qualification with either weapon.

Conclusion
SMs with polytrauma demonstrated a high rate of weapon qualification (accuracy) following VRE-based firearm training. Shot group size (precision) at short distances with a M9 pistol and M4 rifle also improved with training. While overall marksmanship appeared to improve, high return to duty rates were not directly related to firearm training or marksmanship. Future efforts need to focus on consistent clinical documentation of firearm training procedure and the establishment of psychometric properties for marksmanship outcome measures.
A multiwavelength analysis of a collection of short-duration GRBs observed between 2012 and 2015
Authors: Pandey S B , Hu Y , Castro-Tirado Ao J , Pozanenko A S , Sánchez-Ramírez R , Gorosabel J , Guziy S , Jelinek M , Tello J C , Jeong S , Oates S R , Zhang B-B , Mazaeva E D , Volnova A A , Minaev P Yu , van Eerten H J , Caballero-García M D , Pérez-Ramírez D , Bremer M , Winters J-M , Park I H , Guelbenzu A Nicuesa , Klose S , Moskvitin A , Sokolov V V , Sonbas E , Ayala A , Cepa J , Butler N , Troja E , Chernenko A M , Molkov S V , Volvach A E , Inasaridze R Ya , Egamberdiyev Sh A , Burkhonov O , Reva I V , Polyakov K A , Matkin A A , Ivanov A L , Molotov I , Guver T , Watson A M , Kutyrev A , Lee W H , Fox O , Littlejohns O , Cucchiara A , Gonzalez J , Richer M G , Román-Zúñiga C G , Tanvir N R , Bloom J S , Prochaska J X , Gehrels N , Moseley H , de Diego J A , Ramírez-Ruiz E , Klunko E V , Fan Y , Zhao X , Bai J , Wang Ch , Xin Y , Cui Ch , Tungalag N , Peng Z-K , Kumar Amit , Gupta Rahul , Aryan Amar , Kumar Brajesh , Volvach L N , Lamb G P , Valeev A F 
Published: February 2019

AbstractWe investigate the prompt emission and the afterglow properties of short-duration gamma-ray burst (sGRB) 130603B and another eight sGRB events during 2012–2015, observed by several multiwavelength facilities including the Gran Canarias Telescope 10.4 m telescope. Prompt emission high energy data of the events were obtained by INTEGRAL-SPI-ACS, Swift-BAT, and Fermi-GBM satellites. The prompt emission data by INTEGRAL in the energy range of 0.1–10 MeV for sGRB 130603B, sGRB 140606A, sGRB 140930B, sGRB 141212A, and sGRB 151228A do not show any signature of the extended emission or precursor activity and their spectral and temporal properties are similar to those seen in case of other short bursts. For sGRB 130603B, our new afterglow photometric data constrain the pre-jet-break temporal decay due to denser temporal coverage. For sGRB 130603B, the afterglow light curve, containing both our new and previously published photometric data is broadly consistent with the ISM afterglow model. Modeling of the host galaxies of sGRB 130603B and sGRB 141212A using the LePHARE software supports a scenario in which the environment of the burst is undergoing moderate star formation activity. From the inclusion of our late-time data for eight other sGRBs we are able to: place tight constraints on the non-detection of the afterglow, host galaxy, or any underlying ‘kilonova’ emission. Our late-time afterglow observations of the sGRB 170817A/GW170817 are also discussed and compared with the sub-set of sGRBs.
3D simulations of planet trapping at disc–cavity boundaries
Authors: Romanova M M , Lii P S , Koldoba A V , Ustyugova G V , Blinova A A , Lovelace R V E , Kaltenegger L 
Published: February 2019

Abstract
Inward migration of low-mass planets and embryos of giant planets can be stopped at the disc–cavity boundaries due to co-orbital corotation torque. We performed the first global three-dimensional (3D) simulations of planet migration at the disc–cavity boundary, and have shown that the boundary is a robust trap for low-mass planets and embryos. A protoplanetary disc may have several such trapping regions at various distances from the star, such as at the edge of the stellar magnetosphere, the inner edge of the dead zone, the dust-sublimation radius and the snow lines. Corotation traps located at different distances from a star, and moving outward during the disc dispersal phase, may possibly explain the observed homogeneous distribution of low-mass planets with distance from their host stars.