bluuebunny/crossref_metadata_2025_split huggingface dataset:
Re-Layout Lantai 1 dan Ruang Lurah Pada Gedung Kantor Kelurahan Kramatjati Jakarta Timur
Authors: Sudarwani Margareta Maria , Septania Sally , Sri Pare Eni  , Dianty Grace Putri , Charles Gabrielle , Lesilolo Jourdan , Indri Jessica Miracella 
Published: November 2024

ABSTRACT
Comfort in the subdistrict office is an important factor in creating a productive work environment and supporting optimal public service performance. The subdistrict office is an entity that functions as a representation of the local government that is directly related to the needs of the community. Therefore, the comfort of the subdistrict office is crucial because it has the potential to improve the quality of public services, strengthen the relationship between the government and residents, and support employee welfare. Currently, the decreasing number of office employees has caused the Kramatjati Subdistrict Office to be too overloaded in accommodating activities and as a result of the office usage schedule, the Kramatjati Sucdistrict Office seems not to be optimally utilized, so it is necessary to redesign or re-design several rooms in the Kramatjati Subdistrict Office. so that it is more aesthetic and comfortable and more organized so that it can increase comfort in carrying out activities in the office. Therefore, the solution to the problem that was carried out was the Re-layout program for the 1st Floor and Subdistrict Head Room in the Kramat Jati Subdistrict Building. In this Collaboration Program, the UKI Architecture Study Program was asked for assistance from partners to provide design proposals for the Re-layout for the 1st Floor and Subdistrict Head Room. This activity involves lecturers and students of the Architecture Study Program, Faculty of Engineering, Indonesian Christian University as an effort to contribute to society in the field of architectural science.

Keywords: re-layout, subdistrict head’s room, Subdistrict Office Building, Kramatjati.
Di-[trioctyl-(8-phenyloctyl)-phosphonium] pamoate: synthesis and characterization of a novel, highly hydrophobic ionic liquid for the extraction of scandium, thorium and uranium
Authors: Gradwohl Andreas , Windisch Jakob , Rosner Alexander , Heninger Julia , Fuhrmann Philipp L. , Wallner Gabriele , Keppler Bernhard K. , Kandioller Wolfgang , Jirsa Franz 
Published: November 2024

We synthesized and characterized a novel, task-specific ionic liquid for metal extraction with considerably reduced leaching behavior compared to similar, phosphonium-based ionic liquids. The synthesis involves the design of the novel compound [TOPP]2[PAM] featuring both a highly hydrophobic cation and a functional anion. The characterization of the novel ionic liquid confirmed the formation of the desired structure and sufficient purity. The high viscosity of [TOPP]2[PAM] is responsible for the comparably high working temperature of 50°C. Extraction experiments demonstrated the suitability of [TOPP]2[PAM] for extracting Sc, Th and U from aqueous matrices, whereby extraction efficacies of 87.3% ± 9.1% (Sc), 95.8% ± 2.3% (Th) and 92.7% ± 0.3% (U) were achieved over 24 h. Furthermore, Sc could be separated to a high degree via selective extraction from Th as well as from the rare earth elements Y, La, Ce, Nd, Eu, Ho and Lu. Th was separated from La, Ce, Nd, Eu, Ho and Lu at pH 1.00. During all extraction experiments, leaching into the aqueous extraction matrix peaked at only 0.134% ± 0.011% after 24 h. The loading capacities for [TOPP]2[PAM] differed between the investigated metals, the highest values being achieved for U. After extraction, 82.7% ± 2.8% of the extracted Sc could be recovered from the IL using nitric acid (10%), but less of Th and U.
Hospitalizations and cardiac sarcoidosis: insights into presentation and diagnosis from the nationwide readmission database
Authors: Abraham Jacob , Spinelli Kateri , Li Hsin-Fang , Pham Tuan , Wang Mansen , Sheikh Farooq H. 
Published: November 2024

IntroductionCardiac sarcoidosis (CS) is an increasingly recognized cause of cardiac disease. Because the clinical presentation of CS is non-specific, the diagnosis is often delayed. Early detection is essential to initiate treatments that reduce the risk of heart failure (HF) and arrhythmic death. We therefore aimed to describe the features of CS hospitalizations during which the initial diagnosis of CS is made.MethodsWe performed a retrospective analysis of hospitalizations from 2016 to 2019 in the Nationwide Readmission Database (NRD). Hospitalizations with a primary diagnosis suggestive of CS (HF/cardiomyopathy, cardiac arrest, arrhythmias, or heart block) were categorized into cases with and without CS as a secondary diagnosis (CS+ and CS−, respectively). One-to-one propensity score matching (PSM) was performed.ResultsThe CS+ cohort comprised 1,146 hospitalizations and the CS− cohort 3,250,696 hospitalizations. The CS+ cohort included patients who were younger and more often male. PSM resulted in highly matched cohorts (absolute standardized mean difference &lt;0.1). Primary diagnoses of ventricular arrhythmias (VA) or heart block were more frequent in matched CS+ hospitalizations, whereas primary diagnosis of HF/cardiomyopathy was more frequent in matched CS− hospitalizations. The matched CS+ group exhibited higher rates of in-hospital procedures and longer length of stay. In-hospital mortality and 30-day readmission were similar between matched cohorts.DiscussionThese findings highlight increased rates of CS in younger males with primary diagnoses of VA and heart block, and increased use of diagnostic and therapeutic interventions such as pacemaker and left ventricular assist device implantation, and could aid clinicians in more timely diagnosis and treatment of CS.
A systematic review of soft skills interventions within curricula from school to university level
Authors: Orih Dominic , Heyeres Marion , Morgan Rhian , Udah Hyacinth , Tsey Komla 
Published: November 2024

BackgroundSoft skills are increasingly promoted in curricula, writ large in its scholarly interest over the last decade. Yet systematic literature reviews covering all educational stages are lacking. This review addresses this gap by examining soft skills interventions across all educational levels, evaluating their characteristics, design quality, and outcomes.MethodsA comprehensive search was conducted across ERIC, Scopus, Informit A+ Education, and Google Scholar databases from 2012 to 2022 to identify peer-reviewed studies on soft skills interventions within education curricula at all levels. Study characteristics were extracted, analysed and synthesised to inform conclusion. Quality assessment was performed using The Critical Appraisal Skills Programme (CASP) and the Effective Public Health Practice Project (EPHPP) evaluation tools. This study is registered at PROSPERO (CRD42022309833).ResultsThe search yielded 5,689 records, and after eligibility assessment, 38 studies were included. These studies employed various interventions that span three categories namely, workshop-based, creative-based, and project-based approaches, to enhance students’ soft skills. Reported outcomes encompassed improved soft skills, employability, career planning, social–emotional learning, academic performance, and reduced issues like violence, drug abuse, depression, and bullying. Quality appraisal using CASP and EPHPP tools identified three studies as “best practice” among the 38. The review highlights diverse interventions and positive impacts on students’ holistic development through soft skills programs.ConclusionThe analysis of 38 studies underscores the shortage of literature on soft skills in primary and secondary schools compared to universities, a lack of high-quality “best practice” resources for soft skills development, and a tendency for control group participants to miss vital soft skills training. While randomised controlled trials (RCTs), considered as gold standard, informed ‘best practice’ studies, RCTs may not fully capture the nuances of complex social interventions like soft skills programs. Therefore, there is need for alternative approaches, such as continuous quality improvement studies using mixed methods. Consequently, we recommended that future research consider these aspects to enhance the effectiveness of soft skills development in curricula.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022309833, identifier CRD42022309833.
Using anti-Müllerian hormone to predict premature ovarian insufficiency: a retrospective cross-sectional study
Authors: Huang Yuanxin , Kuang Xiaojun , Jiangzhou Huiting , Li Meiling , Yang Dongjian , Lai Dongmei 
Published: November 2024

BackgroundPremature ovarian insufficiency/failure (POI/POF) is a significant issue for women of reproductive age. Anti-Müllerian hormone (AMH) is a potential biomarker of ovarian reserve, but its clinical value in diagnosing and predicting POI/POF remains unclear. This study aimed to analyze the correlation between AMH and basal follicle-stimulating hormone (FSH) levels in women aged 18 to 40 and evaluate AMH’s predictive value for POI/POF.MethodsA total of 21,143 participants aged 18-40 who visited the gynecology department or underwent physical examinations at the International Peace Maternity and Child Health Hospital in Shanghai, China, from July 2016 to June 2021 were enrolled. Demographic information and laboratory test results were collected, including age, FSH, AMH, E2 and test dates. Participants were grouped by FSH and AMH levels, and subgroup analyses were performed to investigate the relationship between these hormones and age. The AMH level associated with POI risk was evaluated using restricted cubic splines (RCS) and logistic regression. Clinical benefit was assessed by decision curve analysis (DCA).ResultsParticipants with higher FSH levels had significantly lower median AMH levels and vice versa(p&lt;0.001). At AMH ≥ 0.5 ng/mL, FSH levels were normal or slightly elevated with age. At AMH level below 0.5ng/ml,basal FSH increased significantly with age. At FSH &lt;10 IU/L, AMH levels show a trend of rising and then decreasing with age, reaching a peak at approximately 25 years old and gradually decreasing with age. At FSH ≥10 IU/L, AMH levels show a gradual downward trend with age, and at FSH &gt;40 IU/L, AMH levels remain very low to undetectable values. The RCS showed that the risk of POI/POF in the overall population sharply increased until serum AMH reached a low level (below 0.5ng/ml). DCA showed that a low AMH level had good clinical diagnostic utility in predicting POI/POF.ConclusionOur analysis of a large dataset suggests that serum AMH levels are inversely correlated with FSH levels and that AMH is a good predictor of POI until it drops to a low level.
Analysis of mooring performance and layout parameters of multi-segment mooring system for a 15 MW floating wind turbine
Authors: Huang Jianwu , Xu Hang , Chen Li , Lin Kuigeng , Guo Mingyuan , Yang Mindong , Rui Shengjie 
Published: November 2024

IntroductionFloating wind power is the important path for the development of offshore wind energy, and the performance of the mooring system of floating wind turbines (FOWTs) significantly affects their economic viability, safety, and sustainability.MethodsThis paper systematically analyses the positioning performance, mooring line extreme loads, and fatigue response of a FOWT equipped with both single segment and multi-segment mooring systems, based on the IEA 15 MW large turbine and a floating platform. The hydrodynamic performance of the floating platform is calculated, and the platform’s motion-sensitive directions are analysed through Response Amplitude Operators (RAOs). The natural periods of the platform are validated by free decay tests. The six degrees of freedom (DOFs) motion response and the mooring line peak tensions are analysed under normal and extreme conditions.ResultsThe results show that both mooring systems provide good motion performance and stable tilt angles for the platform. Under ALS (single-line failure) condition, the multi-segment mooring system demonstrates a notable capacity to resist impact loads, with comparatively minor fluctuations in mooring line tension. In the multi-segment system, fatigue damage primarily occurs in the upper mooring chain, with damage approximately 4.5 times greater than that of the bottom chain over a 1-year period. The effects of mooring line spread angles and lengths on performance are also analysed. The results indicate that the mooring line spread angle has slight impact on platform motion response and mooring line tension, while mooring line length significantly affects the extreme tension of the lines.DiscussionThe findings of this study can provide some references in the design of mooring systems for future FOWTs.
Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway
Authors: Ruan Shirong , Jia Rumeng , Hu Liang , Liu Yuge , Tian Qingyan , Jiang Kunmao , Xia Xinyue , Tao Xueyou , Liu Wen-Tao , Pan Yinbing , Hu Fan 
Published: November 2024

BackgroundNeuropathic pain (NPP) is a multifaceted pain syndrome that occurs as a consequence of physical injury or underlying diseases, with an incidence rate of 7%-10%, NPP poses a significant clinical challenge as current treatment options are ineffective. The accumulation of apoptotic cells and neuroinflammation play crucial roles in the pathological mechanisms of NPP. Here, we aim to investigate strategies for effectively clearing apoptotic cells and provide therapeutic interventions for NPP.MethodsCCI mice were treated with different concentrations of ozone (15μg, 30μg, 45μg) to investigate the effects on the accumulation of apoptotic cells and neuroinflammation. In vitro, the phagocytic function of BMDM towards apoptotic neutrophils after ozone treatment was examined.ResultsWe found ozone at a concentration of 30μg significantly alleviated mechanical hypersensitivity in CCI mice and ozone significantly upregulates the phagocytic activity of BMDM. Furthermore, we investigated the mechanisms and found ozone could activate AMPK, upregulate Gas6 (but not Protein S), activate MerTK (a key receptor involved in apoptosis), and enhance the phagocytic function of BMDM towards apoptotic neutrophils. It caused the promotion of SOCS3 expression and the suppression of inflammatory factors IL-1β, IL-6, and TNF-a. Interestingly, the effect of ozone in alleviating CCI-induced pain was abolished by the AMPK inhibitor CC and the MerTK receptor inhibitor UNC2541.ConclusionOzone facilitated macrophage clearance of apoptotic cells, decreased neuroinflammation by activation of p-AMPK/Gas6/MerTK/SOCS3 signaling pathway, which may become an effective therapeutic approach for neuropathic pain after further clinical validation.
Cocktail vaccine for the management of Hyalomma anatolicum and Rhipicephalus microplus
Authors: Manjunathachar Haranahally Vasanthachar , Kumar Binod , Parthasarathi Balasamudram Chandrasekhar , Chigure Gajanan M. , Saravanan Buddhi Chandrasekaran , Sankar Muthu , Harish Darasaguppe Ramachandra , de la Fuente José , Ghosh Srikanta 
Published: November 2024

IntroductionGlobally, ticks rank second only to mosquitoes as vectors of deadly pathogens affecting humans and first in transmitting animal pathogens, presenting a significant challenge to human wellness and sustainability of livestock-based industries. Traditional tick control via chemical acaricides impacts on the environment and has led to the emergence of multi-acaricide-resistant tick populations. Use of immunoprophylactic, along with other components of integrated tick management, holds the potential to mitigate tick infestations in a sustainable manner. To control multi-species tick infestations, the concept of a cocktail vaccine comprising of more than one antigens has emerged as a viable solution due to the inconsistent efficacy of single antigen-based immunization protocol.MethodsIn this study, a dual antigen cocktail immunization protocol was developed targeting ferritin2 (FER2) and tropomyosin (TPM) proteins, which are associated with ticks’ essential cellular and physiological functions, like blood iron homeostasis and muscle contractions.ResultsDual gene silencing of FER2 and TPM genes in Hyalomma anatolicum resulted in a 75.3% reduction in infested ticks, a 95.4% decrease in egg masses, and a complete loss of egg hatching when compared to control ticks. Microscopically, an altered ovarian cellular architecture, marked by vacuolation and reduced nucleus-to-cytoplasmic ratio were noted in the gene knocked down ticks. An immunization with cocktails of 300 µg dose of each protein, rHaFER2 and rHaTPM was standardized in a rat model and was used to immunize cross-bred (Bos indicus x B. taurus) male cattle with Montanide ISA 50V2 adjuvant on days 0, 28, and 49. A significant (p &lt; 0.001) IgG and IgG2 antibody response was observed in the immunized animals with high IgG levels sustained until day 119 post-primary immunization, showing a 4.1-fold increase over the pre-immunization period. The animals were challenged with larvae and adults of H. anatolicum and larvae of Rhipicephalus microplus. Immunization with the cocktail antigen resulted an efficacy of 70% and 76% against H. anatolicum larvae and adults, respectively, and 54% against R. microplus infestations. Compared to single-antigen immunization, the immunization with cocktail antigens demonstrated higher protection against R. microplus and H. anatolicum ticks. The results advance the development of cocktail vaccines to control multiple tick species.
Alpha-1-antitrypsin as novel substrate for S. aureus’ Spl proteases – implications for virulence
Authors: Scherr Franziska , Darisipudi Murthy N. , Börner Friedemann R. , Austermeier Sophie , Hoffmann Franziska , Eberhardt Martin , Abdurrahman Goran , Saade Christopher , von Eggeling Ferdinand , Kasper Lydia , Holtfreter Silva , Bröker Barbara M. , Kiehntopf Michael 
Published: November 2024

BackgroundThe serine protease like (Spl) proteases of Staphylococcus aureus are a family of six proteases whose function and impact on virulence are poorly understood. Here we propose alpha-1-antitrypsin (AAT), an important immunomodulatory serine protease inhibitor as target of SplD, E and F. AAT is an acute phase protein, interacting with many proteases and crucial for prevention of excess tissue damage by neutrophil elastase during the innate immune response to infections.MethodsWe used MALDI-TOF-MS to identify the cleavage site of Spl proteases within AAT’s reactive center loop (RCL) and LC-MS/MS to quantify the resulting peptide cleavage product in in vitro digestions of AAT and heterologous expressed proteases or culture supernatants from different S. aureus strains. We further confirmed proteolytic cleavage and formation of a covalent complex with Western Blots, investigated AAT’s inhibitory potential against Spls and examined the NETosis inhibitory activity of AAT-Spl-digestions.ResultsSplD, E and F, but not A or B, cleave AAT in its RCL, resulting in the release of a peptide consisting of AAT’s C-terminal 36 amino acids (C36). Synthetic C36, as well as AAT-SplD/E/F-digestions exhibit NETosis inhibition. Only SplE, but not D or F, was partly inhibited by AAT, forming a covalent complex.ConclusionWe unraveled a new virulence trait of S. aureus, where SplD/E/F cleave and inactivate AAT while the cleavage product C36 inhibits NETosis.
Chitooligosaccharides improves intestinal mucosal immunity and intestinal microbiota in blue foxes
Authors: Wei Jiali , Su Jing , Wang Guiwu , Li Wei , Wen Zhengshun , Liu Huitao 
Published: November 2024

ObjectiveGut health is critical to the health of the host. This study was conducted to investigate the effects of Chitooligosaccharides (COS) on intestinal morphology, intestinal barrier, intestinal immunity and cecum microbiota of blue foxes.MethodsSeventy-two 125-day-old blue foxes were randomly divided into basal diet (BD) group, 200 ppm COS1 (1.5 kDa) group and 200 ppm COS2 (3 kDa) group for 8 weeks.ResultsWe elucidated that dietary COS1 supplementation promoted the development of intestinal villus morphology in blue foxes. Importantly, COS1 increased the number of goblet cells in duodenum, jejunum and ileum by 27.71%, 23.67%, 14.97% and S-IgA secretion in duodenum, jejunum and ileum by 71.59% and 38.56%, and up-regulate the expression of Occludin and ZO-1 by 50.18% and 148.62%, respectively. Moreover, COS1 promoted the pro-inflammatory and anti-inflammatory balance of small intestinal mucosa, and increased the diversity of cecum microbiota of blue foxes, especially Lactobacillus_agilis and Lactobacillus_murinus, and up-regulated the signaling pathways related to polysaccharide decomposition and utilization.ConclusionHere, we present dietary COS1 (1.5 kDa) can promote intestinal villus development, enhance intestinal barrier function, regulate intestinal immune balance and cecum microbiota homeostasis.
Transgender and gender diverse individuals embodying endometriosis: a systematic review
Authors: Giacomozzi Maddalena , Bouwens Jip , Aubin Stéphane Guy , Pastoor Hester , Verdonk Petra , Nap Annemiek 
Published: November 2024

BackgroundTransgender and gender diverse (TGD) people embody social and health inequalities that disproportionately affect this community more than the cisgender population. Endometriosis is a chronic condition of the reproductive tract that affects 5–10% of cisgender women. A recent systematic review with meta-analysis uncovered a pooled prevalence of 25.14% among TGD individuals undergoing gender-affirming surgeries.ObjectiveThis study aims to investigate the causes of the gap in prevalence of endometriosis between the TGD community and the cisgender population.MethodsA systematic review with a fit-for-framework analysis was conducted. Results were analysed according to the adjusted developmental framework for embodiment with an intersectional approach. Sources were categorised in multi-levels relating to the framework mechanisms of expression, shaping, interaction, and incorporation.ResultsFour hundred twenty-three (423) studies published between 2001 and 2024 in English and Spanish were identified on the PubMed, Web of Science, Sociological abstracts, and PsycInfo databases. Thirty-two (32) peer-reviewed sources were selected.DiscussionThe higher prevalence of endometriosis among TGD people compared to the cisgender population reflects a complex phenomenon whereby individual biomedical characteristics, and psychological and environmental factors interplay on multiple levels throughout one’s lifespan. The prevalence gap is striking in a context where TGD people experience great barriers and delays to access healthcare, and endometriosis is typically understood as a “women’s disease.” TGD people express lifestyle and environmental factors correlated with endometriosis more often than cisgender women, such as history of trauma, low self-image, obesity. Endometriosis interacts with one’s quality of life, and especially with gendered expectations related to menstruations, family planning and sexuality. This interference can result in biographical disruption and gender self-perception changes in both cisgender and TGD people. Exogenous testosterone use as gender-affirming therapy results in amenorrhea in 80% of cases. However, endometrium and follicular activities are still reported upon testosterone use suggesting endometriosis may be active. It is hypothesised that testosterone use could lead to a hyper-estrogenic state that would stimulate endometriosis proliferation.