bluuebunny/crossref_metadata_2025_split huggingface dataset:
Line-to-Line Reaming of Highly Porous Acetabular Components Improves Position and Reduces Variability of Component Placement
Authors: Antioch Valentin , Heaven Sebastian , Bedair Hany 
Published: February 2018

AbstractAccurate and precise acetabular component position in total hip arthroplasty remains challenging even for experienced, high-volume surgeons. Some variability may result from the press-fit technique of cementless components and maybe magnified by the use of highly porous cups with high-friction surfaces. The purpose of this study is to investigate the acetabular component positioning of a hemispherical, highly porous cup with line-to-line reaming compared with press-fit techniques. A retrospective cohort study was performed of 110 consecutive primary total hip arthroplasties performed by a single surgeon using a highly porous acetabular component. Half of the patients had the component implanted with a line-to-line reaming technique and the other half were implanted using a 1 mm press-fit technique. Postoperative radiographs were evaluated for component positioning and loosening at a minimum of 1 year postoperatively by two independent surgeons. Records were reviewed for subsequent surgery. There were no differences between the groups with respect to age, sex, body mass index, operative side, or acetabular component size. The press-fit group had an average abduction angle of 49.4 ± 5° and anteversion of 20.6 ± 7°. The line-to-line group had an average abduction angle of 45.02° [standard deviation (SD) 4.58] and anteversion of 25.42° (SD 4.44) and were statistically different from the press-fit group (p < 0.01). There was significantly less variability in the line-to-line group with respect to anteversion (F-test, p < 0.01) compared with the press-fit group. At most recent follow-up, there were no dislocations, revisions for any reason, or radiographic evidence of loosening in either group. Line-to-line reaming for highly porous cups can improve component positioning and reduce variability compared with press-fit techniques with no difference in fixation or other clinical outcome parameters.
Pediatric Transjugular Intrahepatic Portosystemic Shunts
Authors: Shin David , Shivaram Giridhar , Koo Kevin , Monroe Eric 
Published: February 2018

AbstractTransjugular intrahepatic portosystemic shunt (TIPS) creation offers potentially life-saving portal decompression regardless of patient age or size, but has been underutilized in pediatric patients to date. Experience has therefore been limited, and the full clinical benefit in this population is yet to be realized. Those wishing to embark on pediatric TIPSs would benefit not only from significant experience in adult TIPSs, but also from an awareness of challenges posed by the unique pediatric population. We herein review the etiologies and manifestations of portal hypertension more common in children, highlight some of the technical nuances of creating TIPSs in smaller anatomy, and summarize the existing literature on the topic. As extrahepatic portal vein occlusion (EHPVO) occurs with greater frequency in pediatric patients, special attention is paid to this condition and its associated challenges.
Subject and Academic Setting of Pre-residency Publications as Potential Predictors of Post-residency Academic Productivity in a Cohort of Ophthalmology Residents
Authors: Cruz Franz , Wang Jiangxia , Joseph Shannon , Miller Neil 
Published: February 2018

Objective This study aimed to determine if there is any association between the subject of pre-residency research publications (PRPs) and the academic settings in which they are produced with post-residency academic productivity among graduates from an academic ophthalmology residency program.
Design, Setting, Participants This is a cross-sectional study involving graduates of the Wilmer Eye Institute Residency Training Program from 1990 to 1999. An electronic survey was conducted and each participant was asked to submit his/her curriculum vitae, including a list of peer-reviewed publications. Publications were validated and then classified according to the academic setting in which the research was performed, and whether or not the research was related to ophthalmology.
Outcome Measures The primary outcome measure was the post-residency academic productivity score. The secondary outcome measures were the relationships of academic productivity with the settings in which PRPs were performed and the topics of the PRPs.
Results Fifty-one individuals were included. Regression analysis showed a positive association between the number of PRPs generated during undergraduate studies and medical school and the academic productivity score (ratio = 1.17, p = 0.006) but not during an advanced degree program, research fellowship, or a year off to perform research. Regardless of the setting in which it was performed, the subject of a PRP was not associated with academic productivity.
Conclusion It may be appropriate for ophthalmology residency programs whose mission is to train future academicians to place increased weight on applicants who have published articles related to projects performed during undergraduate years or in medical school and less weight on publications related to research performed during a more structured research period, such as an advanced degree program, regardless of the subject(s) of the publication(s).
Kinematically Aligned Total Knee Arthroplasty or Mechanically Aligned Total Knee Arthroplasty
Authors: Ansari Juned , Pandit Hemant , Takahashi Tsuneari 
Published: February 2018

AbstractKinematically aligned total knee arthroplasty (KATKA) was developed to more anatomically align the knee prosthesis to restore the native alignment of the knee and promote physiological kinematics. Even though there are concerns with implant survival, and follow-up at 10 years or more after KATKA has not been reported, there is a negligible incidence of failure of a tibial component at 2 to 9 years. Early clinical results with this technique are encouraging and demonstrate better functional outcomes compared with mechanically aligned TKA (MATKA). The purpose of this study is to perform a systematic review and meta-analysis of the literature to determine whether there are any clinical differences between KATKA and MATKA. The authors conducted a systematic review of the English literature. Five randomized controlled trials (RCTs) which compared clinical outcomes of KATKA and MATKA were finally included. Four RCTs used patient-specific instrument, and one RCT used navigation. Data were extracted and meta-analysis was conducted. KATKA patients had better outcomes: Mean difference between KATKA and MATKA and p-value are presented in brackets after each variable: the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (–12.5; p < 0.0001), Oxford Knee Score (OKS) (2.3; p = 0.030), combined Knee Society Score (C-KSS) (13.1; p < 0.0001), Knee Function Score (KFS) (6.4; p = 0.0070), and postoperative range of motion (ROM) (4.1°; p = 0.0010). There was no significant difference concerning the complication rates which needed reoperations or revision surgery (odds ratio, 1.01; p = 0.99). KATKA components had a more femoral valgus (–1.8°; p < 0.0001), more tibial varus (1.2°; p = 0.0001), and more tibial slope (1.2°; p = 0.0001), all being statistically significantly different. Better clinical outcomes were obtained in KATKA and component placement in KATKA is significantly different from that in MATKA. There was no increase of patients with poor clinical results due to implant position especially for varus placement of tibial component. This systematic review of five RCTs suggests that KATKA is of potential alternative method to MATKA since the risk of revision for tibial loosening is negligible compared with MATKA for the same follow-up period.
Effekte eines judospezifischen Messplatztrainings auf kinetische und elektromyografische Parameter des Anreißens bei Wurfeingangsbewegungen von Judoka
Authors: Helm Norman , Prieske Olaf , Muehlbauer Thomas , Krüger Tom , Granacher Urs 
Published: February 2018

Zusammenfassung
Hintergrund Schnellkräftige Wurfeingangsbewegungen stellen im Judo entscheidende Voraussetzungen für den Wettkampferfolg dar, weshalb das Training der Anrissbewegung ein zentrales Element des judospezifischen Trainings darstellt. Das Ziel der Studie bestand darin, die Effekte eines Anrisstrainings mit einem Judoergometer-System (ATJ) gegenüber einem tradierten Anrisstraining mit Partner (ATP) auf kinetische und elektromyografische Parameter des Anreißens bei Wurfeingangsbewegungen von Judoka zu untersuchen. Methode Männliche leistungsorientierte Judoka (N = 24, Alter: 22 ± 4 Jahre; Trainingserfahrung: 15 ± 3 Jahre) wurden randomisiert in zwei Gruppen aufgeteilt. Im Crossover-Design absolvierte die erste Gruppe über vier Wochen ein ATJ gefolgt von vier Wochen ATP (je 3x/ Woche). Die zweite Gruppe führte beide Trainingsvarianten in umgekehrter Reihenfolge durch. ATJ und ATP wurden zusätzlich zum bestehenden Training absolviert. Vor dem Training sowie nach vier und nach acht Wochen Training wurden Tests zur Erfassung kinetischer Parameter (dynamisch-realisierte Maximalkraft, Explosivkraft, mechanische Arbeit) und elektromyografischer (EMG) Schulter-/ Rumpfmuskelaktivitäten (M. biceps brachii, M. deltoideus, M. trapezius, M. erector spinae) für die Hub- und Zugarmseite bei Wurfeingangsbewegungen am Judoergometer sowie sportartunspezifische Krafttests (d. h. Liegend-Anreißen, Klimmziehen) durchgeführt.
Ergebnisse Die Ergebnisse der statistischen Analyse ergaben über den gesamten Interventionszeitraum (8 Wochen) für beide Trainingsgruppen signifikante Verbesserungen der kinetischen Parameter (p <,05; 0,83 ≤d≤ 1,77) und EMG-Aktivitäten (p <,05; 1,07 ≤d≤ 2,25). Darüber hinaus zeigten sich größere Zuwachsraten in der Explosivkraft, der mechanischen Arbeit und den Schulter-/Rumpfmuskelaktivitäten (M. deltoideus, M. erector spinae, M. trapezius) zugunsten von ATJ im Vergleich zu ATP (p <,05; 1,25 ≤d≤ 2,79). Für die sportartunspezifischen Kraftwerte wurden keine signifikanten Veränderungen festgestellt.
Schlussfolgerung Die vorliegenden Ergebnisse zeigen, dass ATJ gegenüber ATP größere Steigerungsraten von kinetischen und elektromyografischen Parametern des Anreißens bei Wurfeingangsbewegungen von Judoka bewirkt. Die trainingsbedingten Leistungssteigerungen scheinen zumindest teilweise auf neuronalen Anpassungen zu beruhen.
Doubly hybrid density functionals that correctly describe both density and energy for atoms
Authors: Su Neil Qiang , Zhu Zhenyu , Xu Xin 
Published: February 2018

SignificanceIt was commented that some modern density functional theory functionals may be giving the correct energies for the wrong reason and functionals that produce “right” energies from “wrong” densities fail twice. However, the route to the “heaven” of the “Jacob’s ladder” is incomplete in Medvedev et al. [Medvedev MG, et al. (2017)Science355:49–52], as the authors did not provide any information on the top fifth-rung functionals. We fill the gap to show here that the XYG3 type of doubly hybrid density functionals (xDHs) can correctly describe both density and energy for the same atomic set used by Medvedev et al., such that electronic structure calculations for molecular sciences of the main group elements can be carried out reliably by using xDHs.
flowLearn: fast and precise identification and quality checking of cell populations in flow cytometry
Authors: Lux Markus , Brinkman Ryan Remy , Chauve Cedric , Laing Adam , Lorenc Anna , Abeler-Dörner Lucie , Hammer Barbara 
Published: February 2018

AbstractMotivationIdentification of cell populations in flow cytometry is a critical part of the analysis and lays the groundwork for many applications and research discovery. The current paradigm of manual analysis is time consuming and subjective. A common goal of users is to replace manual analysis with automated methods that replicate their results. Supervised tools provide the best performance in such a use case, however they require fine parameterization to obtain the best results. Hence, there is a strong need for methods that are fast to setup, accurate and interpretable.ResultsflowLearn is a semi-supervised approach for the quality-checked identification of cell populations. Using a very small number of manually gated samples, through density alignments it is able to predict gates on other samples with high accuracy and speed. On two state-of-the-art datasets, our tool achieves median(F1)-measures exceeding 0.99 for 31%, and 0.90 for 80% of all analyzed populations. Furthermore, users can directly interpret and adjust automated gates on new sample files to iteratively improve the initial training.Availability and implementationFlowLearn is available as an R package on https://github.com/mlux86/flowLearn. Evaluation data is publicly available online. Details can be found in the Supplementary Material.Supplementary informationSupplementary data are available at Bioinformatics online.
Combining co-evolution and secondary structure prediction to improve fragment library generation
Authors: de Oliveira Saulo H P , Deane Charlotte M 
Published: February 2018

Abstract

Motivation
Recent advances in co-evolution techniques have made possible the accurate prediction of protein structures in the absence of a template. Here, we provide a general approach that further utilizes co-evolution constraints to generate better fragment libraries for fragment-based protein structure prediction.

Results
We have compared five different fragment library generation programmes on three different datasets encompassing over 400 unique protein folds. We show that considering the secondary structure of the fragments when assembling these libraries provides a critical way to assess their usefulness to structure prediction. We then use co-evolution constraints to improve the fragment libraries by enriching them with fragments that satisfy constraints and discarding those that do not. These improved libraries have better precision and lead to consistently better modelling results.

Availability and implementation
Data is available for download from: http://opig.stats.ox.ac.uk/resources. Flib-Coevo is available for download from: https://github.com/sauloho/Flib-Coevo.

Supplementary information
Supplementary data are available at Bioinformatics online.
The lncLocator: a subcellular localization predictor for long non-coding RNAs based on a stacked ensemble classifier
Authors: Cao Zhen , Pan Xiaoyong , Yang Yang , Huang Yan , Shen Hong-Bin 
Published: February 2018

Abstract

Motivation
The long non-coding RNA (lncRNA) studies have been hot topics in the field of RNA biology. Recent studies have shown that their subcellular localizations carry important information for understanding their complex biological functions. Considering the costly and time-consuming experiments for identifying subcellular localization of lncRNAs, computational methods are urgently desired. However, to the best of our knowledge, there are no computational tools for predicting the lncRNA subcellular locations to date.

Results
In this study, we report an ensemble classifier-based predictor, lncLocator, for predicting the lncRNA subcellular localizations. To fully exploit lncRNA sequence information, we adopt both k-mer features and high-level abstraction features generated by unsupervised deep models, and construct four classifiers by feeding these two types of features to support vector machine (SVM) and random forest (RF), respectively. Then we use a stacked ensemble strategy to combine the four classifiers and get the final prediction results. The current lncLocator can predict five subcellular localizations of lncRNAs, including cytoplasm, nucleus, cytosol, ribosome and exosome, and yield an overall accuracy of 0.59 on the constructed benchmark dataset.

Availability and implementation
The lncLocator is available at www.csbio.sjtu.edu.cn/bioinf/lncLocator.

Supplementary information
Supplementary data are available at Bioinformatics online.
Message Pretesting Using Assessments of Expected or Perceived Persuasiveness: Evidence About Diagnosticity of Relative Actual Persuasiveness
Authors: O’Keefe Daniel J 
Published: February 2018

AbstractDo formative assessments of the expected or perceived effectiveness of persuasive messages provide a good guide to the relative actual effectiveness of those messages? The correlational evidence usually invoked on this question is less than ideal. The most relevant evidence compares two messages’ relative standing on perceived message effectiveness (PME) and actual message effectiveness (AME) as assessed in separate samples. Across 151 such comparisons, the direction of difference in PME matched that of AME in 58% of cases (ns). Diagnostic accuracy did not differ significantly depending on the size or significance of the PME difference, the size of the PME sample, whether PME assessments came from experts or target-audience representatives, the referent of the PME assessment, or whether the PME assessment involved comparing messages.
Flow Diversion of Posterior Circulation Cerebral Aneurysms: A Single-Institution Series of 59 Cases
Authors: Bender Matthew T , Colby Geoffrey P , Jiang Bowen , Lin Li-Mei , Campos Jessica K , Xu Risheng , Westbroek Erick M , Vo Chau D , Zarrin David A , Caplan Justin M , Huang Judy , Tamargo Rafael J , Coon Alexander L 
Published: February 2018

Abstract

BACKGROUND
Posterior circulation cerebral aneurysms are at higher risk of rupture and are more symptomatic than those in the anterior circulation. Existing treatments carry significant morbidity. Early reports of flow diversion for posterior circulation aneurysms have suggested high complication and low occlusion rates.

OBJECTIVE
To report safety and efficacy of flow diversion with the pipeline embolization device (ev3, Medtronic Inc, Dublin, Ireland) for aneurysms located throughout the posterior circulation.

METHODS
A prospective, institutional review board-approved database was analyzed for all patients with posterior circulation aneurysms treated by flow diversion at our institution.

RESULTS
Fifty-nine embolization procedures were performed on 55 patients. Average aneurysm size was 9.4 mm. Morphology was saccular (45%), fusiform (29%), or dissecting/pseudo-aneurysms (25%). Sixty-two percent of aneurysms arose along the vertebral artery. There were 7 mid-basilar (13%) and 7 basilar apex (13%) aneurysms. Procedural success was 98%; 1 Pipeline embolization device was placed in 85%; and coiling was performed in 17% of cases. There were 5 major complications (8%), all strokes. Patients with major stroke had modified Rankin Scale score at last follow-up of 1, 3, 4, 6, and 6 (2 mortalities). There were zero intracerebral or subarachnoid hemorrhages. No variable predicted complications on univariate or multivariate analysis. Follow-up digital subtraction angiography was performed for 43 patients (78%). Complete occlusion was 68% at 6 mo and 78% at 12 mo. Average follow-up was 11.8 mo. Fusiform or dissecting morphology and large or giant aneurysm size were predictors of aneurysm persistence at 6 mo on multivariate logistic regression.

CONCLUSION
This is a large single-institution series of Pipeline (Medtronic Inc) for posterior circulation aneurysms and demonstrates acceptable safety and effectiveness in these challenging cases.
Effects of a Home-Based Telephone-Supported Physical Activity Program for Older Adult Veterans With Chronic Low Back Pain
Authors: Goode Adam P , Taylor Shannon Stark , Hastings Susan N , Stanwyck Catherine , Coffman Cynthia J , Allen Kelli D 
Published: February 2018

Abstract

Background
Chronic low back pain (CLBP) is highly prevalent in older adults, leading to functional decline.

Objective
The objective of this study was to evaluate physical activity (PA) only and PA plus cognitive-behavioral therapy for pain (CBT-P) among older adult veterans with CLBP.

Design
This study was a pilot randomized trial comparing a 12-week telephone–supported PA-only intervention group (PA group) or PA plus CBT-P intervention group (PA + CBT-P group) and a wait-list control group (WL group).

Setting
The study setting was the Durham Veterans Affairs Health Care System.

Participants
The study participants were 60 older adults with CLBP.

Interventions
The PA intervention included stretching, strengthening, and aerobic activities; CBT-P covered activity pacing, relaxation techniques, and cognitive restructuring.

Measurements
Feasibility measures included enrollment and completion metrics; acceptability was measured by completed phone calls. Primary outcomes included the Timed “Up & Go” Test and the PROMIS Health Assessment Questionnaire. Generalized linear mixed models were used to estimate changes within and between groups. Effect sizes were calculated with the Cohen d. Adverse effects were measured by self-report.

Results
The mean participant age was 70.3 years; 53% were not white, and 93% were men. Eighty-three percent of participants completed the study, and the mean number of completed phone calls was 10 (of 13). Compared with the results for the WL group, small to medium treatment effects were found for the intervention groups in the Timed “Up & Go” Test (PA group: −2.94 [95% CI = −6.24 to 0.35], effect size = −0.28; PA + CBT-P group: –3.26 [95% CI = −6.69 to 0.18], effect size = −0.31) and the PROMIS Health Assessment Questionnaire (PA group: −6.11 [95% CI = −12.85 to 0.64], effect size = −0.64; PA + CBT-P group: –4.10 [95% CI = –11.69 to 3.48], effect size = −0.43). Small treatment effects favored PA over PA + CBT-P. No adverse effects were noted.

Limitations
This was a pilot study, and a larger study is needed to verify the results.

Conclusions
This pilot trial demonstrated that home-based telephone-supported PA interventions were feasible, acceptable, and safe for older adult veterans. The results provide support for a larger trial investigating these interventions.
Grover Disease With Epidermal Dysmaturation Pattern: A Common Histopathologic Finding
Authors: Aljarbou Ohoud Z. , Asgari Masoud , Al-Saidi Nagla , Silloca-Cabana Elizabeth O. , Alathamneh Mamoun , P. Sangueza Omar 
Published: February 2018

Background:
Grover disease is an entity whose diagnosis is based on clinicopathologic correlation. Histopathologically, focal acantholysis is the most common finding. In some cases, there is prominent squamous atypia which can prove to be very challenging and the lesion may be confused with an epidermal neoplasm.

Objective:
To report on atypical histopathological changes in Grover disease and to provide helpful clues to differentiate between the epidermal atypia seen in some cases of Grover disease and epithelial neoplasms.

Material and Methods:
We analyzed 33 cases of Grover disease histologically diagnosed at Wake Forest Baptist Medical Center, NC, between 2011 and 2017. Atypical changes in keratinocytes were defined as epithelial buds, nuclear pleomorphism, and dyskeratosis in all layers of epidermis or altered granular layer.

Results:
Twenty cases (64%) showed foci with alteration of the normal keratinocytic maturation, whereas 18 cases demonstrated nuclear pleomorphism. Buds of epithelial cells emanating from the basal layer of the epidermis and granular cell alteration was present in 19 cases.

Conclusions:
The findings especially the presence of an altered granular layer may represent a diagnostic clue in cases of Grover disease with atypical changes.