bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon Dioxide Absorption into Stirred Emulsions of n‐Alkanes
Authors: Mohsenzadeh Elmira , Schumpe Adrian 
Published: October 2018

AbstractVolumetric mass transfer coefficients kLa for CO2 absorption into n‐alkane/water emulsions were determined at oil volume fractions of 0–100 % in a stirred tank at a stirring speed of 1000 min−1. The oil was n‐heptane, n‐hexadecane, or n‐dodecane. The decrease of kLa with increasing volume fraction of dispersed oil can be uniformly correlated to the emulsion viscosity with the power of −0.72. Only the addition of n‐heptane caused a strong increase of the mass transfer coefficient. Upon addition of the surfactant sodium dodecyl sulfate to n‐heptane emulsions, kLa decreased as for the other oils. The increase can therefore be attributed to the spreading of n‐heptane on the bubble surface enabling gas‐oil contact, whereas spreading is inhibited by the ionic surfactant.
Phosphine Oxidation with Water and Ferrocenium(III) Cation Induced by Visible‐Light Irradiation
Authors: Tanabe Yoshiaki , Nakajima Kazunari , Nishibayashi Yoshiaki 
Published: October 2018

AbstractStoichiometric oxidation of phosphines with water and ferrocenium(III) cation as the oxygen atom source and the oxidizing reagent, respectively, was achieved in acetonitrile under visible‐light irradiation by using 2,6‐lutidine as the proton acceptor. The reaction required light irradiation, under which fluorescence was observed for the acetonitrile solution of the ferrocenium(III) cation.
Unsuspected Stewart–Treves syndrome clinically mimicked by apparent bullous erysipelas and a systematic review of dermatological presentations of the classical Stewart–Treves syndrome
Authors: da Costa Vieira René Aloisio , de Araujo Silva Igor , de Oliveira‐Junior Idam , de Almeida Santos Yamashita Mauricio Eiji , da Silva Sandra Regina Morini 
Published: October 2018

AbstractBackgroundStewart Treves–Syndrome (STS) was first characterized as angiosarcoma in the homolateral limb of a patient with breast cancer and lymphedema. Now, other conditions represent STS. It's a rare condition. The diagnosis is easier in the presence of single or multiple purple nodules. Even though other dermatological aspects have been reported, no study has grouped its characteristics.AimEvaluate the dermatological characteristics of classical STS (c‐STS).Methods and ResultsWe report a patient with chronic lymphedema with a history of recurrent erysipelas that rapidly developed multiple papules in the superior limb. It was initially diagnosed as bullous erysipelas, but unsatisfactory evolution led to biopsy, which demonstrated an unsuspected epithelioid angiosarcoma. We have also performed a review of dermatologic aspects of c‐STS using PubMed and Lilacs databases. PICTOS methodology and PRISMA flow chart were considered. The main dermatological aspects associated with c‐CTS were summarized. Using a systematic evaluation from 109 articles, 29 were selected and 44 patients were described to whom we added one case. The mean time with lymphedema was 10 years. Of the patients analyzed, 97.2% were female; 95.6% were submitted to radical mastectomy; 81.2% presented with multiple lesions, 67.4% of the lesions were reported as nodules or tumors, 53.4% were purple, 33.4% were associated with an ecchymotic halo, and 33.4% were ulcerated lesions.ConclusionWhen evaluating patients with chronic lymphedema with new dermatological abnormalities, clinical suspicion, or unfavorable evolution, the knowledge of clinical signs is important for diagnosis, and a biopsy must be considered. Papules associated with erythematous‐wine color and bluish hematoma aspect must raise clinical suspicion.
Objects as culture‐specific referents of color terms in Russian
Authors: Griber Yulia A. , Mylonas Dimitris , Paramei Galina V. 
Published: October 2018

AbstractThe present study is an extension of our analysis of Russian basic color terms (BCTs) elicited in a web‐based psycholinguistic experiment. Color samples (N = 600) were approximately uniformly distributed in the Munsell color solid. An unconstrained color‐naming method was employed. Native Russian speakers (N = 713; 333 males) participated in the study. Among 1422 elicited unique color words, 698 terms (49%) were derived from object names. Here we explore object‐derived non‐BCTs, focusing on broad classes of names referred to objects, categories within these, and the inventory of color terms, as well as their frequency, patterns of derivation, and derivational productivity. Six classes of object referents were identified: flora, fauna, inanimate nature, food and beverages, man‐made objects, body and bodily products. In detail, 20 most frequent object‐derived terms are reported. These are accompanied by analysis of gender differences and representation of the terms' denotata on the Munsell Mercator projection. In addition, Russian object‐derived color terms are related to those in English; discussed are differences between the 2 languages in the color term classes, inventories and incidences. We conclude that Russian object‐derived color terms follow the generic metonymy pattern, that is, signifying color of objects in the speakers' natural environment. The inventory is also language‐specific, reflecting social practices, preferences and views entrenched in the traditional Russian culture. Furthermore, recent extensive development of the inventory signals 2 novel phenomena: marked globalization influence, surfacing as abundant transliteration of English referent loanwords, and noticeable sociolectal diversification that manifests itself by novel evocative color terms, particularly in marketing and advertisement.
Improved Utilization of Sunlight Through the Incidence Dependence of the Photonic Stop Band: A g‐C3N4‐Embedded Fluorine‐Doped Tin Oxide (FTO) Photonic Crystal Film
Authors: Xiao Ye , Chen Mengshi , Zhang Menglong 
Published: October 2018

AbstractPhotonic crystal fluorine‐doped tin oxide (PC‐FTO) films are fabricated on FTO glass to supply an available surface area to embed a photoactive material, and also improve the overall photon–electron conversion efficiency under illumination with light of a specific incident range. The nanoscale g‐C3N4 photocatalyst is synthesized directly inside the PC‐FTO film from a liquid precursor, without the addition of any surface reagent or noble metal particles. The photonic stop band (PSB) of the PC‐FTO is studied by diffuse‐reflectance UV/Vis absorption spectroscopy (DRUVS) under conditions of a different incidence angle of the light. Photoelectrochemistry (PEC) is used to demonstrate the influence of the PSB on the photocatalytic performance of g‐C3N4@PC‐FTO.
Participation of ATP‐sensitive K+ channels and μ‐opioid receptors in the antinociceptive synergism of the paracetamol–tapentadol co‐administration in the formalin‐induced pain assay in mice
Authors: Zapata‐Morales Juan R. , Alonso‐Castro Ángel J. , Pérez‐Gutiérrez Salud , Rojas‐Bedolla Edgar Isaac , Sánchez‐Enriquez Sergio , Rivas‐Carrillo Jorge David , Serafín‐Higuera Nicolás A. , Isiordia‐Espinoza Mario A. 
Published: October 2018

Abstract

Preclinical Research & Development

The purpose of this study was to assess the interaction and mechanisms of action of the paracetamol‐tapentadol combination in the formalin‐induced pain model in mice. Paracetamol (56.23–562.3 mg/kg, i.p.) or tapentadol (1–10 mg/kg, i.p.) were administered 15 min prior the intraplantar injection of formalin. The ED50 value of each drug was determined through the dose–response curves. The ED50 values were used to calculate the combinations in three fixed proportions (1:1, 1:3, and 3:1). Naloxone (1 and 5 mg/kg, i.p.), L‐NAME (3 mg/kg, i.p.), or glibenclamide (10 mg/kg, i.p.) were administered before the combination of drugs to evaluate the antinociceptive mechanisms of action. The results showed that the combination 1:1 and paracetamol3‐tapenadol1 ratios produced additive effects, whereas the paracetamol1‐tapentadol3 proportion showed an antinociceptive synergistic interaction. Moreover, naloxone and glibenclamide reversed the antinociceptive activity of the paracetamol‐tapentadol mixture. Our results indicate that the paracetamol‐tapentadol combination produces an antinociceptive synergistic interaction with the possible participation of ATP‐sensitive K+ channels and μ‐opioid receptors in the second phase of the formalin‐induced pain model in mice.
Sulfate metabolites improve retrospectivity after oral testosterone administration
Authors: Esquivel Argitxu , Alechaga Élida , Monfort Nuria , Ventura Rosa 
Published: October 2018

AbstractThe detection of testosterone (T) misuse is performed using the steroid profile that includes concentrations of T and related metabolites excreted free and glucuronoconjugated, and the ratios between them. In this work, the usefulness of 14 endogenous steroid sulfates to improve the detection capabilities of oral T administration has been evaluated. Quantitation of the sulfate metabolites was performed using solid‐phase extraction and analysis by liquid chromatography–tandem mass spectrometry. Urine samples were collected up to 144 hours after a single oral dose of T undecanoate (120 mg) to five Caucasian male volunteers. Detection times (DTs) of each marker were estimated using reference limits based on a population study and also monitoring the individual threshold for each volunteer. High inter‐individual variability was observed for sulfate metabolites and, therefore, better DTs were obtained using individual thresholds. Using individual threshold limits, epiandrosterone sulfate (epiA‐S) improved the DT with respect to testosterone/epitestosterone (T/E) ratio in all volunteers. Androsterone, etiocholanolone, and two androstanediol sulfates also improved DTs for some volunteers. Principal component analysis was used to characterize the sample cohort, obtaining 13 ratios useful for discrimination. These ratios as well as the ratio epiA‐S/dehydroepiandrosterone sulfate were further examined. The most promising results were obtained using ratios between sulfates of epiA, androsterone, or androstanediol 1 and E, and also sulfates of epiA or androstanediol 1, and dehydroandrosterone. These selected ratios prolonged the DT of oral T administration up to 144 hours, which corresponded to a significantly higher retrospectivity compared to those obtained using concentrations or the conventional T/E ratio.
The importance of competition for light depends on productivity and disturbance
Authors: Hautier Yann , Vojtech Eva , Hector Andy 
Published: October 2018

AbstractEutrophication is a major cause of biodiversity loss. In grasslands, this appears to occur due to asymmetric competition for light following the increases in aboveground biomass production. Here, we report the results of an experiment with five grass species that tests how well‐competitive outcomes can be predicted under a factorial combination of fertilized and disturbed (frequent cutting) conditions. Under fertile conditions, our results confirm earlier success in predicting short‐term competitive outcomes based on light interception in monocultures. This effect was maintained but weakened under less fertile conditions with competition becoming more symmetric. However, under disturbed conditions, competitive outcomes could not be predicted from differences in light interception in monocultures regardless of fertility. Our results support the idea that competition in grasslands shifts from symmetric to asymmetric as fertility increases but that disturbance destroys this relationship, presumably by preventing the development of differences in canopy structure and reducing competition for light.
SSR‐seq: Genotyping of microsatellites using next‐generation sequencing reveals higher level of polymorphism as compared to traditional fragment size scoring
Authors: Šarhanová Petra , Pfanzelt Simon , Brandt Ronny , Himmelbach Axel , Blattner Frank R. 
Published: October 2018

AbstractMicrosatellites (or simple sequence repeats, SSR) are widely used markers in population genetics. Traditionally, genotyping was and still is carried out through recording fragment length. Now, next‐generation sequencing (NGS) makes it easy to obtain also sequence information for the loci of interest. This avoids misinterpretations that otherwise could arise due to size homoplasy. Here, an NGS strategy is described that allows to genotype hundreds of individuals at many custom‐designed SSR loci simultaneously, combining multiplex PCR, barcoding, and Illumina sequencing. We created three different datasets for which alleles were coded according to (a) length of the repetitive region, (b) total fragment length, and (c) sequence identity, in order to evaluate the eventual benefits from having sequence data at hand, not only fragment length data. For each dataset, genetic diversity statistics, as well asFSTandRSTvalues, were calculated. The number of alleles per locus, as well as observed and expected heterozygosity, was highest in the sequence identity dataset, because of single‐nucleotide polymorphisms and insertions/deletions in the flanking regions of the SSR motif. Size homoplasy was found to be very common, amounting to 44.7%–63.5% (mean over all loci) in the three study species. Thus, the information obtained by next‐generation sequencing offers a better resolution than the traditional way of SSR genotyping and allows for more accurate evolutionary interpretations.
Preliminary insights into the genetics of bank vole tolerance to Puumala hantavirus in Sweden
Authors: Rohfritsch Audrey , Galan Maxime , Gautier Mathieu , Gharbi Karim , Olsson Gert , Gschloessl Bernhard , Zeimes Caroline , VanWambeke Sophie , Vitalis Renaud , Charbonnel Nathalie 
Published: October 2018

AbstractNatural reservoirs of zoonotic pathogens generally seem to be capable of tolerating infections. Tolerance and its underlying mechanisms remain difficult to assess using experiments or wildlife surveys. High‐throughput sequencing technologies give the opportunity to investigate the genetic bases of tolerance, and the variability of its mechanisms in natural populations. In particular, population genomics may provide preliminary insights into the genes shaping tolerance and potentially influencing epidemiological dynamics. Here, we addressed these questions in the bank vole Myodes glareolus, the specific asymptomatic reservoir host of Puumala hantavirus (PUUV), which causes nephropathia epidemica (NE) in humans. Despite the continuous spatial distribution of M. glareolus in Sweden, NE is endemic to the northern part of the country. Northern bank vole populations in Sweden might exhibit tolerance strategies as a result of coadaptation with PUUV. This may favor the circulation and maintenance of PUUV and lead to high spatial risk of NE in northern Sweden. We performed a genome‐scan study to detect signatures of selection potentially correlated with spatial variations in tolerance to PUUV. We analyzed six bank vole populations from Sweden, sampled from northern NE‐endemic to southern NE‐free areas. We combined candidate gene analyses (Tlr4, Tlr7, and Mx2 genes) and high‐throughput sequencing of restriction site‐associated DNA (RAD) markers. Outlier loci showed high levels of genetic differentiation and significant associations with environmental data including variations in the regional number of NE human cases. Among the 108 outliers that matched to mouse protein‐coding genes, 14 corresponded to immune‐related genes. The main biological pathways found to be significantly enriched corresponded to immune processes and responses to hantavirus, including the regulation of cytokine productions, TLR cascades, and IL‐7, VEGF, and JAK–STAT signaling. In the future, genome‐scan replicates and functional experimentations should enable to assess the role of these biological pathways in M. glareolus tolerance to PUUV.
Modeling population dynamics in a microbial consortium under control of a synthetic pheromone‐mediated communication system
Authors: Hoffmann Andreas , Haas Christiane , Hennig Stefan , Ostermann Kai , Bley Thomas , Löser Christian , Walther Thomas 
Published: October 2018

AbstractMicrobial consortia can be used to catalyze complex biotransformations. Tools to control the behavior of these consortia in a technical environment are currently lacking. In the present study, a synthetic biology approach was used to build a model consortium of two Saccharomyces cerevisiae strains where growth and expression of the fluorescent marker protein EGFP by the receiver strain is controlled by the concentration of α‐factor pheromone, which is produced by the emitter strain. We have developed a quantitative experimental and theoretical framework to describe population dynamics in the model consortium. We measured biomass growth and metabolite production in controlled bioreactor experiments, and used flow cytometry to monitor changes of the subpopulations and protein expression under different cultivation conditions. This dataset was used to parameterize a segregated mathematical model, which took into account fundamental growth processes, pheromone‐induced growth arrest and EGFP production, as well as pheromone desensitization after extended exposure. The model was able to predict the growth dynamics of single‐strain cultures and the consortium quantitatively and provides a basis for using this approach in actual biotransformations.
A Generalized Correlation for Predicting Ethane, Propane, and Isobutane Hydrates Equilibrium Data in Pure Water and Aqueous Salt Solutions
Authors: Aregbe Azeez G. 
Published: October 2018

AbstractHydrate formation can cause serious problems in hydrocarbon exploration, production, and transportation, especially in deepwater environments. Hydrate‐related problems affects the integrity of the deepwater platforms, leads to equipment blockages, and also increases operational costs. In order to solve these problems, salts are used as thermodynamic inhibitors and also mixed with the drilling fluids in most drilling processes. A comprehensive understanding of hydrate formation in aqueous salt solutions is vital to overcome these problems. Statistical thermodynamic models are commonly used to predict hydrate formation conditions in different aqueous solutions. However, these models involve rigorous computations and are restricted to certain conditions. They give inaccurate predictions of hydrate equilibrium conditions for high‐temperature, high‐pressure, and high‐salinity systems. Therefore, it is paramount to develop a simple‐to‐use and reliable prediction tool. In this work, an empirical correlation is developed and successfully used to predict the equilibrium conditions of ethane, propane, and isobutane hydrates in pure water and aqueous solutions of sodium chloride, potassium chloride, calcium chloride, and magnesium chloride. Experimental data on hydrate formation conditions for these components are regressed and a generalized correlation is obtained. The predictions in this work show excellent agreement with all the experimental data in the literature.
ATTACHMENT AND BIOBEHAVIORAL CATCH‐UP: A SYSTEMATIC REVIEW
Authors: Grube Whitney A. , Liming Kiley W. 
Published: October 2018

ABSTRACTAttachment Biobehavioral Catch‐up (ABC; Dozier et al., 2006) is a 10‐week, in‐home intervention primarily for early childhood aged children (ages 6 months–2 years). The ABC intervention seeks to teach parents how to provide nurturing care and engage in appropriate interactions with their children. ABC has been identified as a Level 1 evidence‐based practice by the California Evidence‐Based Clearinghouse for Child Welfare. However, to date, there has been no systematic review presenting the overall evidence behind ABC available in a peer‐reviewed journal. The objective of this review is to address this gap by synthesizing prior literature and evidence, specifically evidence from randomized control trials (RCTs), regarding the effectiveness of the ABC intervention and to determine the contexts in which the intervention has been implemented. To complete this review, literature was searched across three bibliographic databases and relevant Web sites. Only RCTs examining child outcomes were included in the review. Using identified search procedures, 10 articles discussing RCTs which tested the efficacy of ABC were identified. Findings indicate that ABC is effective, when implemented with child‐welfare‐involved children, at improving emotion regulation, improving externalizing and internalizing behaviors, increasing normative developmental functioning, and attachment quality. Sample information from the 10 RCTs identified is presented as well as additional study characteristics.
Hotair mediates tumorigenesis through recruiting EZH2 in colorectal cancer
Authors: Huang Kai‐bin , Zhang Shi‐pai , Zhu Yong‐jun , Guo Chun‐hua , Yang Min , Liu Jun , Xia Li‐gang , Zhang Jin‐fang 
Published: October 2018

AbstractLong noncoding RNAs (lncRNA) have been demonstrated to extensively participate in a wide spectrum of biological activities ranging from embryogenesis and cancer progression. HOX transcript antisense RNA (Hotair), an lncRNA located in the HOXC locus, has been reported to play an important role in carcinogenesis. As a well‐known oncogene, it potentiates cancer metastasis and tumor progression. And it also serves as a biomarker for poor prognosis and tumor recurrence. In this study, Hotair was found to be upregulated in colorectal cancer (CRC) cells and clinical specimens. Further investigation showed that knockdown of Hotair dramatically suppressed cell proliferation and colony formation, suggesting that Hotair may stimulate tumorigenesis of CRC. The enhancer of zeste homolog 2 (EZH2), a regulator of epigenetic modification, was upregulated in CRC cells and clinical samples. And the silence of EZH2 significantly suppressed cell viability and colony formation. Furthermore, the RNA immunoprecipitation assay revealed that Hotair directly bound EZH2 in CRC cells. In conclusion, Hotair mediated tumorigenesis via recruiting EZH2, which might shed light on the development of a novel therapeutic approach for patients with CRC.
Ultrasensitive prostate‐specific antigen level as a predictor of biochemical progression after robot‐assisted radical prostatectomy: Towards risk adapted follow‐up
Authors: Grivas Nikolaos , de Bruin Daan , Barwari Kurdo , van Muilekom Erik , Tillier Corinne , van Leeuwen Pim J. , Wit Esther , Kroese Wouter , van der Poel Henk 
Published: October 2018

BackgroundUltrasensitive prostate‐specific antigen (USPSA) is useful for stratifying patients according to their USPSA‐based risk. Aim of our study was to determine the usefulness of USPSA as predictor of biochemical recurrence (BCR) after robot‐assisted radical prostatectomy (RARP).MethodsThis retrospective study included 213 prostate cancer patients who had a postoperative USPSA between 0.01 and 0.2 ng/mL and at least 2 years of follow‐up. We developed predictive models for BCR with PSA ≥0.2 and ≥0.5 ng/mL.ResultsA total of 103 patients (48.3%) had BCR at a median follow‐up of 13.3 months. Higher postoperative USPSA (odds ratio [OR] = 4.73, P < 0.01), bilateral positive surgical margin in both sides (OR = 1.32, P = 0.044), higher average PSA rise (OR = 1.67, P = 0.031), ISUP grade group ≥3 (OR = 1.48, P = 0.003), and shorter interval since RARP (OR = 0.58, P < 0.001) were independent predictors of BCR with PSA ≥0.2 ng/mL. Higher postoperative USPSA (OR = 3.85, P < 0.01), bilateral positive surgical margin (OR = 1.34, P = 0.011), ISUP grade group ≥3 (OR = 1.5, P = 0.002), and shorter interval since RARP (OR = 0.61, P = 0.001) were independent predictors of BCR with PSA ≥0.5 ng/mL. The areas under the curve for the first and second model were 0.865 and 0.834, respectively.ConclusionUltrasensitive PSA after RARP is a useful prognostic indicator of BCR which could guide postoperative risk stratification and layout follow‐up scheduling.