bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mary Magdalene and Pilgrimage
Authors: Anderson Joanne W. 
Published: November 2024

Abstract
This essay evaluates the role of pilgrimage in the development and spread of the cult of Mary Magdalene, taking as its focus the north-south dynamic in western Europe as expressed through art, architecture, and sacred topography. It draws together key primary sources and catalytic scholarly literature on the topic, from the earliest relic collecting and display strategies in the Byzantine East through to the establishment of the major shrines in France, which were to attract thousands of Christian pilgrims. From there, it continues with diffused cultural responses to the major shrines north and south of the Alps, as well as within the mountains themselves. In doing so, the essay offers critical perspective on the shifting approaches of scholars from archival and architectural investigations through regionalism to experiential and ethnographic considerations of the pilgrim’s encounter with these managed sites, past and present.
Mary Magdalene Within and Beyond the Medieval Cloister
Authors: Jansen Katherine L. 
Published: November 2024

Abstract
This article proceeds on two tracks. Part one lays out the historiographical foundation for the second, by arguing that the uptick in Magdalenian studies and interest in the historical figure of Mary Magdalene at the end of twentieth and into the twentieth-first century was due to particular social movements and the specific “turns” in historical writing that accompanied them. First was Second Wave Feminism of the 1960s and 1970s and the scholarship inspired by it that put the spotlight on the roles of women, gender, and body in society. Second was a new interest in the role of the laity in the Roman Catholic Church, partly inspired by Vatican II, and partly inspired by trends in the field of history itself, which had moved historical studies away from studying the institutional church and its elites and toward the everyday people of the parish. And third was the acceptance in scholarly circles of hagiographical materials as a viable source for the study of medieval religion. The second part of the article then uses the insights, methods, and sources of these historical turns to examine how devotion to Mary Magdalene developed in monastic circles in the eleventh century but soon moved beyond the cloister to make her one of the most popular and admired saints of the premodern period.
Nudging recommendation algorithms increases news consumption and diversity on YouTube
Authors: Yu Xudong , Haroon Muhammad , Menchen-Trevino Ericka , Wojcieszak Magdalena 
Published: November 2024

Abstract
Recommendation algorithms profoundly shape users’ attention and information consumption on social media platforms. This study introduces a computational intervention aimed at mitigating two key biases in algorithms by influencing the recommendation process. We tackle interest bias, or algorithms creating narrow nonnews and entertainment information diets, and ideological bias, or algorithms directing the more strongly partisan users to like-minded content. Employing a sock-puppet experiment (n=8,600 sock puppets) alongside a month-long randomized experiment involving 2,142 frequent YouTube users, we investigate if nudging the algorithm by playing videos from verified and ideologically balanced news channels in the background increases recommendations to and consumption of news. We additionally test if providing balanced news input to the algorithm promotes diverse and cross-cutting news recommendations and consumption. We find that nudging the algorithm significantly and sustainably increases both recommendations to and consumption of news and also minimizes ideological biases in recommendations and consumption, particularly among conservative users. In fact, recommendations have stronger effects on users’ exposure than users’ exposure has on subsequent recommendations. In contrast, nudging the users has no observable effects on news consumption. Increased news consumption has no effects on a range of survey outcomes (i.e. political participation, belief accuracy, perceived and affective polarization, and support for democratic norms), adding to the growing evidence of limited attitudinal effects of on-platform exposure. The intervention does not adversely affect user engagement on YouTube, showcasing its potential for real-world implementation. These findings underscore the influence wielded by platform recommender algorithms on users’ attention and information exposure.
Design science in public administration: producing both situational interventions and generic knowledge
Authors: Meijer Albert 
Published: November 2024

Abstract
Design science is making a comeback in the discipline of public administration: inspired by the growing popularity of design thinking, various scholars have highlighted the value of design science for the public sector. This theoretical and methodological article aims to contribute to the academic value of design science and focuses on the “double burden” of design science: how can it be applied in such a way that it generates both (relevant) situational interventions and contributes to (robust) generic academic knowledge? We identify which types of generic academic knowledge can be generated through design science in public administration: theoretical knowledge, design exemplars, methodological knowledge, and normative knowledge. We use these four types of generic knowledge to develop a new perspective on design science. We also present guidelines for design research that aim to generate both situational interventions and generic knowledge. These guidelines emphasize the need to be more rigorous and systematic in the process of design research as to ensure the validity and reliability of the contributions to generic knowledge for the discipline of public administration.
Tailoring cell therapies for diabetic metabolic phenotypes: a comparative study on the efficacy of various umbilical cord-derived cell regimens
Authors: Wang Lingshu , Wang Liming , He Falian , Song Jia , Qiao Jingting , Qin Jun , Chen Li , Hou Xinguo 
Published: November 2024

Abstract
Given the high heterogeneity of type 2 diabetes mellitus (T2DM), it is imperative to develop personalized stem cell infusion regimen for targeted metabolic phenotype in order to ensure optimal therapeutic efficacy. In this study, we conducted a comparative analysis of 4 infusion regimens involving single and repeated infusions of human umbilical cord Wharton’s jelly-derived MSCs (hucMSCs), single infusions of umbilical cord blood mononuclear cells (UCB), and sequential infusions of hucMSCs and UCB in T2DM rats. Results showed all 4 infusion regimens exhibited comparable efficacy in lowering fasting blood glucose levels and suppressing glucagon secretion. Single and double infusions of hucMSCs exhibited a tendency to migrate to the liver, thereby better at ameliorating hepatic glucose metabolism by enhancing glycogen synthesis and storage, promoting glycolysis, inhibiting gluconeogenesis, and improving insulin signal transduction. The sequential infusion of hucMSCs and UCB demonstrated specific cell tropism toward the pancreas, leading to prolonged glucose-lowering effects following a glucose tolerance test, restoration of early-phase insulin secretion, stimulation of islet beta cell proliferation and improvement in the beta/alpha ratio. Multiple injections, regardless of cell type, reduced the expression of systemic chronic inflammatory markers such as IL-1β, IL-6, IL-17, IL-22, and IFN-γ. Finally, a single dose of UCB exhibited a greater tendency to target visceral fat and enhanced effectiveness in regulating levels of total cholesterol and triglycerides. In conclusion, our study provided personalized stem cell regimens for diverse T2DM metabolic phenotypes, thereby offering improved treatment alternatives for future clinical trials and applications.
Statutory trusts, planning law and open spaces: R (on the application of Day) v Shropshire Council
Authors: Brown Lloyd Andrew 
Published: November 2024

Abstract
This case comment argues that the Supreme Court decision in R (on the application of Day) v Shropshire Council [2023] UKSC 8 is significant for two reasons. From a technical standpoint, the judgment rightly preserves the public recreation rights afforded under a statutory trust following an unlawful disposal by a council to a private developer. Not only does this show that statutory trusts bestow subsisting rights, but that public bodies must comply with the statutory schemes imposed upon them. From a public policy standpoint, the ruling also protects local communities’ rights to open spaces and the environment over private development.
Effect of shade and limit feeding in growing beef heifers during periods of heat stress
Authors: DeBord Zachary L , Duncan Zachary M , Pflughoeft Madison G , Suhr Kyler J , Ellis William C , Hollenbeck William R , Montgomery Sean P , Spore Tyler J , Titgemeyer Evan C , Blasi Dale A , Tarpoff Anthony J 
Published: November 2024

Abstract
Experiments were conducted during the summers of 2021 and 2022 to evaluate the effects of feeding strategy and shade on growth performance, animal comfort, water usage, apparent diet digestibility, and ruminal fermentation characteristics of growing heifers during periods of heat stress. In Exp. 1, 852 heifers (initial body weight [BW] = 251 ± 13 kg) were assigned to one of 4 treatments: high-energy diet limit-fed at 2.2% of BW (dry matter [DM] basis; LIM) or high-roughage diet fed for ad libitum intake (ADLIB) with shade (SH) or without shade (NSH). Pen BWs were measured on day 0, weekly from days 14 to 84, day 90, and day 97. Pen weights were used to adjust weekly intakes of LIM. Refusals for ADLIB were targeted at 5% of feed consumed the previous day. Following the 90-d feeding period, a gut-fill equilibration diet was fed to all cattle at 2.5% of BW (DM basis) for 7 d to balance differences in gut-fill between dietary treatments. Dry matter intake was lesser (P &lt; 0.01) for LIM compared with ADLIB. Average daily gain (ADG) and gain:feed (G:F) were greater (P &lt; 0.01) for LIM compared with ADLIB. In addition, ADG and G:F were greater (P &lt; 0.01) for SH compared with NSH. Water usage was less (P &lt; 0.01) for SH heifers compared with NSH and was also less (P &lt; 0.01) for LIM compared with ADLIB. Mean panting scores were lower (P &lt; 0.01) for SH compared with NSH and LIM compared with ADLIB. In Exp. 2, 16 heifers (initial BW = 254 ± 22 kg) were arranged in 4 replicated 4 × 4 Latin squares to evaluate treatments from Exp. 1. Apparent total tract digestibility of DM and organic matter was greater (P &lt; 0.01) for LIM compared with ADLIB. Ruminal pH was more acidic (P = 0.02) for LIM compared with ADLIB. Shade did not affect (P ≥ 0.68) apparent diet digestibility; however, ruminal pH was greater (P &lt; 0.01) for SH compared with NSH. In conclusion, LIM improved feed efficiency, reduced mean panting score, and reduced water usage compared with ADLIB. In addition, SH improved growth performance, reduced water usage, and improved animal comfort during periods of heat stress.
Rates and determinants of COVID-19 vaccine uptake among people living with HIV in Federal Capital Territory, Nigeria
Authors: Etuk Victoria Peter , Sanni Charity , Omonijo Oluwafemi , Atema Stella Ijioma , Lawal Temitayo , Yashim-Ankut Anthonia Murna , Ejinkeonye Ifeyinwa , Onyegbutulem Henry Chijioke , Oyedele Oyewole K , Williams Imoiboho , Andrew Nifarta Peingurta , Okpokoro Evaezi 
Published: November 2024

Abstract

Background
We investigated coronavirus disease 2109 (COVID-19) vaccine uptake and determinants among people living with human immunodeficiency virus (PLHIV) in Federal Capital Territory (FCT), Nigeria.

Methods
This was a cross-sectional study among PLHIV attending antiretroviral therapy clinics in FCT, Nigeria. We utilized an interviewer-administered, semi-structured questionnaire to collect data on COVID-19 vaccine uptake. Vaccine uptake was measured using the question ‘Have you received a COVID-19 vaccine?’ and was confirmed with a vaccination card by the interviewer. Data were analysed using descriptive statistics, χ2 and binary logistic regressions in Stata version 18.0.

Results
Of the 252 study participants, 87 (34.5%) had received at least one dose of a COVID-19 vaccine, with uptake lower in females than males (30.5% vs 46.1%; p=0.022). Being &gt;50 y of age (adjusted odds ratio [aOR] 2.870 [95% confidence interval {CI} 1.049 to 7.858], p=0.040) was associated with higher vaccine uptake, while being virally unsuppressed (aOR 0.313 [95% CI 0.099 to 0.985], p=0.047) and not believing COVID-19 disease is real (aOR 0.324 [95% CI 0.147 to 0.717], p=0.005) were associated with lower odds of vaccine uptake.

Conclusions
Vaccination uptake was low among PLHIV in our study. It is critical to target vaccination campaigns to PLHIV, particularly females and younger people. Proper education about COVID-19 itself would contribute to vaccine uptake.
Quality Metrics for Cesarean Delivery: More Than Just General Anesthesia Rates
Authors: Hofkamp M.P. , Sharpe E.E. , Zakowski M.I. , White R.S. 
Published: November 2024

(J Clin Anesth. 2024;94:111398. https://doi.org/10.1016/j.jclinane.2024.111398)
General anesthesia should be avoided for cesarean deliveries when possible but used when necessary, and sometimes it may be the preferred option. The shift in obstetric anesthesia practices to minimize general anesthesia for cesarean deliveries for maternal safety began in 1997. Hawkins and colleagues reported a 17-fold increase in mortality for patients undergoing general anesthesia for cesarean delivery compared with those receiving regional anesthesia. From 2011 to 2013, maternal mortality in the United States was 17 per 100,000 births, and the proportion of anesthesia-related maternal deaths decreased from 1.6% (1990 to 1997) to 0.2% (2011 to 2013). This reduction is partly attributed to decreased general anesthesia rates for cesarean deliveries.
General Anesthesia for Cesarean Delivery: Can Interinstitutional Variation in Practice Offer Deeper Insights Into Our Choice of Anesthetic Modality?
Authors: Munro A. , Sjaus A. 
Published: November 2024

(Can J Anesth/J Can Anesth. 2024;71:169–174. doi: 10.1007/s12630-023-02634-9)
The practice of using general anesthesia (GA) for cesarean deliveries (CD) has changed over the past 5 decades. This change was sparked by a study demonstrating a high rate of maternal deaths caused by GA that was published in 1997. Significant practice adjustments led to improved safety and decreased anesthesia-related deaths. GA rates differ between institutions.
Presence of the Partner in the Operating Room During A Category 1 Cesarean Section: A Prospective Explorative Study
Authors: Nedergaard H.K. , Weitling E.E. , Rahbech M. , Frøslev-Friis C. , Quitzau L.H. , Strøm T. , Brøchner A.C. , Jensen H.I. 
Published: November 2024

(Int J Obstet Anesth. 2024;57:103939. https://doi.org/10.1016/j.ijoa.2023.103939)
In anesthesiology, numerous clinical emergencies occur daily, with increasing attention to the presence of a partner or relative during these situations. Studies indicate that both patients and families prefer having relatives present, even in severe emergencies, as it may reduce relatives’ posttraumatic stress. This preference extends to parents of severely ill children, who often choose to be present during resuscitation. However, little is known about the partner’s role during emergency cesarean deliveries (CD). A recent review found few studies on this topic, and none focused on the partner’s presence during category 1 CD (CD-1), where there is an immediate threat to the mother and/or fetus.
Risk Factors for Preeclampsia: Received Wisdom Versus Reality
Authors: Kane S.C. , Da Silva Costa F. 
Published: November 2024

(BJOG. 2024;131(1):63. doi: 10.1111/1471-0528.17311)
Prevention of many pregnancy-related complications can be better accomplished when risk factors (RF) for these conditions are considered. An example of this is preeclampsia (PEC), where the preventative measures of aspirin and calcium have been shown to reduce the incidence of the condition. Preventive strategies for PEC are determined heavily by clinical practice guidelines (CPGs), which rely on screening for RFs.
Intrathecal Dexmedetomidine Analgesia After Cesarean Delivery: A Feasibility Trial
Authors: Lamontagne C. , Ouellet A.-M. , Lesage S. , Crochetiere C. 
Published: November 2024

(Can J Anesth/J Can Anesth. 2024;71:161–162. doi:10.1007/s12630-023-02630-z)
A small feasibility study comparing intrathecal dexmedetomidine given for pain after cesarean delivery to the standard treatment found that dexmedetomidine did not control pain as well as the standard treatment of bupivacaine with combined morphine and fentanyl.
CO2 Laser Versus Surgical Deroofing for the Treatment of Hidradenitis Suppurativa Tunnels: A Comparative Multicentric, Retrospective Study
Authors: Sechi Andrea , Caposiena Caro Raffaele Dante , Michelucci Alessandra , Dini Valentina , Piaserico Stefano , Zalaudek Iris , Savoia Francesco , Tartaglia Jacopo 
Published: November 2024

BACKGROUND
Tunnels of hidradenitis suppurativa (HS) are one of the most challenging aspects to manage, and different surgical techniques have been proposed for their treatment. CO2 laser and surgical deroofing are 2 of the most widely used techniques, but no studies have compared them directly.

OBJECTIVE
The objective of this study was to compare the efficacy and outcomes of CO2 laser treatment versus surgical deroofing for HS tunnels, with a focus on healing time, complication rates, pain perception, and cosmetic outcomes.

MATERIALS AND METHODS
The authors performed a multicentric retrospective analysis of 20 patients with HS tunnels who were treated with either CO2 laser (n = 10) or surgical deroofing (n = 10). The primary end point was to compare the 2 procedures in terms of healing time, complication rates, pain, and cosmetic outcome. Outcome measures included Visual Analog Scale for pain, the Vancouver Scar Scale for scar evaluation, and the relapse rate at 6 months. Secondary end point included the identification of variables associated with the healing time.

RESULTS
The mean time to healing was 4.7 ± 1.9 weeks in the CO2 laser group and 10.9 ± 4.1 weeks in the surgical deroofing group (p < .01). Pain score at the first dressing change was lower in the CO2 laser group, with a mean Visual Analog Scale score of 1.7 ± 0.8 in the CO2 laser group and 4.9 ± 1.7 in the surgical deroofing group (p < .01). The mean scar evaluation score using the Vancouver Scar Scale at 6-month follow-up was 2.5 ± 1.3 in the CO2 laser group and 3.4 ± 1.1 in the surgical deroofing group. The number of postprocedural complications was low in both groups (1 in the CO2 laser group and 3 in the surgical deroofing group). The proportion of patients achieving complete healing of the tunnels at 6 months was similar among the CO2 laser and the surgical deroofing group (90% in the CO2 laser group vs 80% in the surgical group).

CONCLUSION
CO2 laser is a safe and effective treatment for HS tunnels, with fast healing rates and low pain perception.
Graded Eyelid Crease Approach to the Superior Orbital Apex: An Anatomical Study
Authors: Tong Jessica Y. , Sung Jeffrey , Chan WengOnn , Psaltis Alkis J. , Selva Dinesh 
Published: November 2024

Purpose:
To describe a graded eyelid crease approach to access the superior orbital apex, and to quantify the working space enabled with the sequential release of structures along the superior orbital rim.

Methods:
Cadaveric dissection study of 7 cadaver heads (14 orbits). This technique involved a subperiosteal approach to the superior orbital apex. This was performed by sequential dissection from 1) the supraorbital neurovascular bundle (SNB) to the zygomaticofrontal suture, 2) extension of this plane to the Whitnall’s tubercle, 3a) dissection around the SNB up to the trochlea while preserving the SNB, or 3b) release and division of the SNB, and finally 4) subperiosteal release of the trochlea. Measurements were taken between each landmark (mean ± 1 SD). With each step, a silicone mold was created of the subperiosteal cavity with maximal orbital retraction, which was maintained within 10 mm from the superior orbital rim. The length (mm), width (mm), height (mm), and weight (g) of the mold were quantified.

Results:
The mean distance from SNB to the zygomaticofrontal suture is 27.0 ± 2.9 mm; zygomaticofrontal suture to Whitnall’s tubercle 8.9 ± 3.1 mm, and SNB to trochlea 4.6 ± 2.7 mm. There was a linear increase in the length, width, and height of the silicone mold with each progressive step. The largest gains in height and weight of the silicone mold were noted progressing from step 2 to 3a.

Conclusion:
Quantitative analysis of the transorbital approach to the superior orbital apex demonstrates that dissection around the SNB provides a wider surgical corridor of access.
The Granulomas of Orbital Sarcoidosis Often Show Foci of Necrosis: A Retrospective Observational Study
Authors: Vongsachang Hursuong , Wolkow Natalie , Stagner Anna M. 
Published: November 2024

Purpose:
To characterize the frequency and extent of necrosis within granulomas among patients diagnosed with orbital sarcoidosis on biopsy.

Methods:
A retrospective review was conducted of patients diagnosed with orbital sarcoidosis at a single institution from 2018 to 2024. Histopathology slides were re-reviewed for evidence of any necrosis or infection. Demographic, laboratory, histopathologic, and radiographic data were gathered for these patients. All findings were presented using descriptive statistics.

Results:
There were 19 total cases of orbital sarcoidosis in the study timeframe. The majority were female (15, 78.9%) with a median age of 49 (range: 11–85) presenting with a unilateral, mass-occupying orbital lesion (n = 16, 84.2%). The lacrimal gland and orbital fibroadipose tissue were the most frequently involved and biopsied. Biopsies from 13 patients (68.4%) had granulomas containing varying amounts of necrosis on histopathology on retrospective review. No fungal or acid-fast microorganisms were detected with special stains; a subset of patients had additional molecular genetic-based microbiologic studies which were also unrevealing.

Conclusions:
Although the histopathology of sarcoidosis is classically described as a “non-necrotizing (noncaseating) granulomas,” granulomas with varying extents of necrosis are more frequently seen in orbital sarcoidosis than previously recognized, or than reported in biopsies from patients with sarcoidosis at other anatomic sites. The presence of necrosis within sarcoidal granulomas should not exclude a diagnosis of sarcoidosis at this site, given that infection is adequately excluded.
From the armchair to contemporary cardiac rehabilitation: the remarkable ongoing journey of exercise training in ischemic heart disease
Authors: Vilela Eduardo M. , Almeida Marta Catarina , Oliveira Cláudia , Nogueira Teresa , Torres Susana , Teixeira Madalena , Sampaio Francisco , Ribeiro José , Oliveira Marco , Bettencourt Nuno , Viamonte Sofia , Fontes-Carvalho Ricardo 
Published: November 2024

Abstract
Exercise is an important physiological activity with several health benefits. In the setting of ischemic heart disease (IHD), the view toward exercise has greatly evolved throughout the years, concurrently to several major advances in the management of this complex entity. Currently, exercise training has broad applications across the IHD continuum as a powerful tool in its overall management, being a core component of comprehensive cardiac rehabilitation programs. Beyond this, exercise has also been incorporated as an integral part of contemporary methodologies aiming to provide diagnostic and prognostic data, such as cardiopulmonary exercise stress testing or stress echocardiography. In this article, we provide a pragmatic overview concerning the role of exercise in IHD, with a focus on its incorporation in cardiac rehabilitation frameworks, while also discussing some of the challenges and unmet needs concerning these interventions.