bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of a Medicinal Chinese Herb on Platelet Function
Authors: Wang Z , Roberts J M , Grant P G , Colman R W , Schreiber A D 
Published: July 2018

SummaryWe investigated the effect of the Chinese herb Injectio Salvia Miltiorrhizae (ISM) on human platelet function in vitro. ISM inhibited platelet aggregation and serotonin release induced by either ADP or epinephrine in a dose dependent manner. This effect of ISM was observed with both gel-filtered platelets (ID50 = 8–30 μg ISM/ml gel-filtered platelets) and platelets in plasma (ID50 = 400–900 μg ISM/ml of platelet-rich plasma). The active molecule(s) in ISM was heat stable, resistant to acid, base and proteolysis and fractionated on Sephadex 6-25 at MW ~ 280. ISM did not interact with the platelet α-adrenergic receptor, but increased cAMP in intact platelets. The results are consistent with the concept that ISM inhibition of platelet aggregation and release is mediated by an increase in platelet cAMP. The exact mechanism whereby ISM increases platelet cAMP appears to be that of inhibition of cyclic AMP phosphodiesterase. The effect of ISM on platelet function is one mechanism which might explain the therapeutic effect of ISM in experimental and clinical coronary artery disease.
Pharmacokinetics and Effects on Fibrinolytic and Coagulation Parameters of Two Doses of Recombinant Tissue-Type Plasminogen Activator in Healthy Volunteers
Authors: Verstraete M , Su C A P F , Tanswell P , Feuerer W , Collen D 
Published: July 2018

SummaryPharmacokinetics and pharmacological effects of two intravenous doses of recombinant tissue-type plasminogen activator (rt-PA) (40 and 60 mg over 90 min) were determined in healthy volunteers. Mean maximum plasma concentrations were 1080 and 1560 ng/ml respectively. The steady state level during subsequent maintenance infusion of 30 mg over 6 h was 250 ng/ml. The pharmacokinetics of rt-PA showed a bi-exponential disappearance from plasma consistent with a 2-compartment model of t½α = 5.7 min, a t½β = 1.3 h and a total clearance of 380 ml/min.Mean fibrinogen levels at the end of the infusions of 40 mg or 60 mg rt-PA over 90 min, measured in thawed plasma samples collected on citrate/aprotinin, decreased to 74% and 57% of the preinfusion values respectively. Plasminogen fell to 55% and 48%, and α2-antiplasmin to 28% and 18% of initial values. No further decrease of these parameters was observed during the infusion of 30 mg rt-PA over 6 h. Only 2% of the preinfusion fibrinogen levels could be recovered as fibrinogen-fibrin degradation products. This moderate extent of systemic fibrinogenolysis is much less than that reported for therapeutic i.v. infusions of streptokinase.
Effect of Indomethacin and Dazoxiben on Intravascular Platelet Aggregation in the Anaesthetized Rabbit
Authors: Honey A C , Lad N , Tuffin D P 
Published: July 2018

Summary
Collagen (10-40 μg kg−1), thrombin (1-10 units kg−1), adenosine diphosphate (ADP; 3-300 pμ kg−1), 1-0-hexadecyl Paf-acether and 1-0-octadecyl Paf-acether (1-300 ng kg−1) administered by bolus intravenous injection each caused dose-dependent thrombocytopoenia accompanied by marked hypotension in anaesthetized rabbits. Responses to ADP and the Paf-acether derivatives were transient in nature (3-8 min) whereas those induced by collagen and thrombin were always of longer duration (5-20 min) and frequently fatal at high doses. Responses to collagen, thrombin, and the Paf-acether derivatives were invariably accompanied by substantial, dose-related increases in plasma levels of thromboxane B2 in samples obtained 30 s after agonist administration, whereas following ADP, no change in plasma thromboxane B2 was detected at any dose level. Indomethacin (3.0 mg kg−1 by infusion) had no effect on responses to thrombin or Paf-acether, partially inhibited collagen-induced thrombocytopenia, and potentiated responses to ADP. In contrast, dazoxiben (10 mg kg−1 by infusion) partially but significantly inhibited responses to thrombin, whereas those induced by collagen, Paf-acether or ADP were unchanged. These results indicate that in this model of intravascular aggregation, whilst platelet responses to collagen and thrombin appear partially dependent on intact cyclic endoperoxide and thromboxane A2 synthetic capacity respectively, responses to ADP and Paf-acether are independent of arachidonate metabolism via cyclo-oxygenase despite measurably increased TXB2 formation in the latter case.
Early Life Epilepsy and Episodic Apnea Revealing an ATP1A3 Mutation: Report of a Pediatric Case and Literature Review
Authors: Benrhouma Hanene , Klaa Hedia , Rouissi Aida , Chaabouni Myriam , Kraoua Ichraf , Youssef-Turki Ilhem , Younes Thouraya 
Published: July 2018

Abstract
ATP1A3 mutations have now been recognized in infants, children, and adults presenting with a diverse group of neurological phenotypes, including rapid-onset dystonia-parkinsonism, alternating hemiplegia of childhood, and most recently, cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss syndrome. The phenotypic spectrum of ATP1A3-related neurological disorders continues to expand. In this case study, we report on early life epilepsy with episodic apnea potentially secondary to ATP1A3 mutation in a Tunisian child.
Einflussfaktoren auf die Rückkehr zur Arbeit bei chronischen Rückenschmerzen
Authors: Allgeier Linda , Bengel Jürgen 
Published: July 2018

Zusammenfassung
Theorie Die Mehrzahl der Menschen erlebt mind. eine Rückenschmerzepisode in ihrem Leben. Patienten mit chronischen Schmerzen verursachen durch Arbeitsunfähigkeit und Inanspruchnahme von Gesundheitsdienstleistungen hohe Kosten. Die Rückkehr an den Arbeitsplatz stellt daher ein zentrales Rehabilitationsziel dar.
Methode Die Literaturrecherche erfolgte in den Datenbanken PSYNDEX, PsycINFO, MEDLINE und ScienceDirect und ergab 27 Artikel.
Ergebnisse Die untersuchten Einflussfaktoren ließen sich in 3 Gruppen einteilen: (1) psychische und psychosoziale, (2) arbeits- und arbeitsplatzbezogene und (3) (gesundheits-)systembezogene Einflussfaktoren. Geringe Genesungserwartungen, Rezidivangst, Fear-avoidance-beliefs und ein Mangel an sozialer Unterstützung am Arbeitsplatz stellen Hindernisse für Return to work dar. Hohe Selbstwirksamkeitserwartungen, Anpassungen des Arbeitsplatzes an die Bedürfnisse des Patienten, sowie Informationen durch Gesundheitsdienstleister wirken sich positiv aus.
Überblick über aktuelle Erkenntnisse berufsbedingter muskuloskeletaler Beschwerden am Bildschirmarbeitsplatz hinsichtlich der Anwendung des Oberflächen-EMGs zur Beanspruchungsmessung
Authors: Nisser Maria , Derlien Steffen , Best Norman 
Published: July 2018

Zusammenfassung
Fragestellung Muskuloskeletale Erkrankungen zählen zu den häufigsten berufsbedingten Erkrankungen. Mittels Oberflächen-Elektromyografie (OEMG) lässt sich der muskuläre Beanspruchungsgrad messen, der die beruflichen Tätigkeiten am Bildschirmarbeitsplatz widerspiegelt. In Untersuchungen konnte eine Korrelation zwischen statischer Haltung mit wiederkehrend gleichen Bewegungen und berufsbedingten muskuloskeletalen Erkrankungen nachgewiesen werden. Vor diesem Hintergrund stellt sich die Frage, ob das OEMG hinreichende Daten zur Analyse körperlicher Beanspruchung am Bildschirmarbeitsplatz liefert.
Material und Methoden Eine systematische Literaturrecherche zu Electromyografy AND Work-Related Disorders innerhalb der Datenbank Web of Science Core Collection wurde durchgeführt.
Ergebnisse Von 124 Abstracts wurden 19 in die Volltextanalyse einbezogen.
Diskussion Die OEMG ist eine effektive Methode muskuläre Beanspruchungen zu erfassen, jedoch fehlen einheitliche Datenpools, um eine Klassifikation der Daten vorzunehmen.
Schlussfolgerung Einheitliche Studiendesigns sind zwingend notwendig, um gesundheitsförderliche Ableitungen treffen zu können.
Physiotherapie bei Chemotherapie-assoziierter peripherer Neuropathie in der pädiatrischen Onkologie – Eine Literaturrecherche
Authors: Jung M. , Rein N. , Fuchs B. 
Published: July 2018

Zusammenfassung
Hintergrund Die Chemotherapie-induzierte periphere Neuropathie (CIPN) ist eine häufige Nebenwirkung von Medikamenten, die zur Behandlung von Krebs eingesetzt werden. Betroffene können unter motorischen, sensorischen und autonomen Nervenschäden leiden. Zur Behandlung der CIPN werden häufig weitere Medikamente verabreicht, die wiederum Nebenwirkungen hervorrufen können. Den Patienten können aber ebenso physiotherapeutische Behandlungen zuteilwerden, um die Symptome zu lindern.
Ziel Das Ziel dieser Arbeit ist es, eine Übersicht über vorhandene Literatur, die sich mit Physiotherapie bei CIPN in der pädiatrischen Onkologie beschäftigt, zu geben.
Methodik Es wurde eine systematische Literaturrecherche in den Datenbanken CINAHL, The Cochrane Library, ERIC, MEDPILOT, PEDro, PsycARTICLES, PsycINFO, PubMed und DIMDI durchgeführt. Weiterhin wird die methodische Qualität der identifizierten Literatur überprüft.
Ergebnis Geeignete Publikationen aus dem Bereich pädiatrische Onkologie wurden nicht gefunden. Allerdings konnten mehrere Publikationen im Bereich Erwachsener identifiziert werden, von denen ein möglicher Transfer auf Kindern hergestellt wurde.
Schlussfolgerung Die Akupunktur erwies sich als effektive Behandlungsmethode zur Schmerzreduktion bei Erwachsenen mit CIPN. Auch Sensomotorisches Training, Balancetraining, Elektrotherapie und alternative Therapieverfahren wie Reiki und Yoga konnten die Symptome der Teilnehmer reduzieren. In dieser Arbeit wird ein Ausblick darauf gegeben, wie CIPN auch bei Kindern mit diesen Maßnahmen erfolgreich behandelt werden könnte. Wirksamkeitsstudien zu diesen Interventionen an Kindern stehen noch aus.
Overview Tumour Disease and Oncologic Therapy During Pregnancy
Authors: Findeklee Sebastian 
Published: July 2018

AbstractNewly diagnosed cancer in pregnancy is an issue with increasing importance, because fulfilling the wish to have a child is shifted later in life. Tumour disease is diagnosed in around 0.1% of all pregnancies in Germany. Most common tumour entities involve the breast, the cervix and the hematopoietic system. As tumour prognosis is not negatively affected by pregnancy and gestation does not disclude oncologic therapy it is important to plan treatment immediately. Oncologic surgery preserving the uterus is not at all limited. Chemotherapy with anthracyclines, taxanes or platinum derivates is possible from the second trimenon on. Only radiotherapy should be avoided during pregnancy. Before initiating therapy, fertility preserving methods like cryopreservation of oocytes and/or ovarian tissue should be offered to the patient. Preterm birth is more common in women with a first diagnosis of cancer during pregnancy. Other negative effects on the child’s future are not yet known. Treatment of pregnant cancer patients should be handled by experienced centres with a multi-professional team.
CTG-Analyse und Sectiorate – Ergebnisse einer deutschlandweiten Umfrage
Authors: Schiermeier Sven , Frisenda Sandra , Reinhard Joscha , Dagres Timoleon , Noé Karl-Günter , Lobmaier Silvia , Schneider Karl , Daumer Martin 
Published: July 2018

Zusammenfassung
Einleitung Die Rate der Sectiones in Deutschland ist in den letzten Jahrzehnten stark angestiegen. Bei der Entscheidung für oder gegen eine Sectio sollen Mikroblutuntersuchungen und computerunterstützte Kardiotokografien helfen.Im Wesentlichen befasst sich diese Studie mit der Frage, wie diese Untersuchungen die Sectiorate möglicherweise beeinflussen.
Methodik Um diese Fragestellung zu untersuchen, stand ein Datensatz über Krankenhäuser in Deutschland zur Verfügung, der durch Crowd Sourcing Fragebogen erhoben wurde. Alle Variablen wurden kategorisiert erhoben. Anhand dieses Datensatzes wurden Zusammenhangsmaße berechnet. Die Zusammenhänge wurden zusätzlich durch Mosaikplots visuell untersucht.
Ergebnisse 97 Fragebogen konnten analysiert werden. Im Datensatz ließen sich deutliche Zusammenhänge zwischen Variablen erkennen. Insbesondere hatten Krankenhäuser, die leitliniengerecht eine fetale Herzfrequenz im Bereich 110–160 bpm als ungefährlich einstuften, im Datensatz eine geringere Sectiorate. Auch Krankenhäuser, die leitliniengerecht die Kardiotokografie nach dem Auswertungsschema des FIGO durchführten, hatten im Datensatz eine vergleichsweise geringere Sectiorate.
Schlussfolgerung Computerunterstützte Analysen der fetalen Herzfrequenz auf Grundlage der FIGO-Richtlinien korrelieren mit einer niedrigeren Sectiorate. Die Durchführung und Weiterentwicklung der computergestützten CTG-Analyse sollte fortgesetzt werden.
Delineating the role of cooperativity in the design of potent PROTACs for BTK
Authors: Zorba Adelajda , Nguyen Chuong , Xu Yingrong , Starr Jeremy , Borzilleri Kris , Smith James , Zhu Hongyao , Farley Kathleen A. , Ding WeiDong , Schiemer James , Feng Xidong , Chang Jeanne S. , Uccello Daniel P. , Young Jennifer A. , Garcia-Irrizary Carmen N. , Czabaniuk Lara , Schuff Brandon , Oliver Robert , Montgomery Justin , Hayward Matthew M. , Coe Jotham , Chen Jinshan , Niosi Mark , Luthra Suman , Shah Jaymin C. , El-Kattan Ayman , Qiu Xiayang , West Graham M. , Noe Mark C. , Shanmugasundaram Veerabahu , Gilbert Adam M. , Brown Matthew F. , Calabrese Matthew F. 
Published: July 2018

Significance
Proteolysis targeting chimera (PROTAC)-based protein degradation is an emerging field that holds significant promise for targeting the “undruggable” proteome: the vast majority of the proteins that do not exhibit enzymatic activity and are thereby not amenable to classical inhibition. Despite significant progress, a thorough mechanistic characterization of biochemical determinants that underpin efficient PROTAC activity is lacking. Here we address one such question: Is positive cooperativity necessary for potent protein degradation? Through a collection of independent techniques, we show that within a Bruton’s tyrosine kinase/cereblon PROTAC system, potent knockdown correlates with alleviation of steric clashes in the absence of thermodynamic cooperativity. This result broadens the scope of PROTAC applications and affects fundamental design criteria across the field.
Idealization and Galileo’s Proto-Inertial Principle
Authors: Van Dyck Maarten 
Published: July 2018

AbstractGalileo proposed what has been called a proto-inertial principle, according to which a body in horizontal motion will conserve its motion. This statement is only true in counterfactual circumstances where no impediments are present. This article analyzes how Galileo could have been justified in ascribing definite properties to this idealized motion. This analysis is then used to better understand the relation of Galileo’s proto-inertial principle to the classical inertial principle.
The Dark Galaxy Hypothesis
Authors: Weisberg Michael , Jacquart Melissa , Madore Barry , Seidel Marja 
Published: July 2018

AbstractGravitational interactions allowed astronomers to conclude that dark matter rings all luminous galaxies in gigantic halos, but this only accounts for a fraction of the total mass of dark matter believed to exist. Where is the rest? We hypothesize that some of it resides in dark galaxies, pure dark matter halos that either never possessed or have totally lost their baryonic matter. This article explores methodological challenges that arise because of the nature of observation in astrophysics and examines how the blend of observation, simulation, and theory we call the Observing the Invisible approach might make detecting such dark objects possible.
Food and nutrition literacy (FNLIT) and its predictors in primary schoolchildren in Iran
Authors: Doustmohammadian Aazam , Keshavarz Mohammadi Nastaran , Omidvar Nasrin , Amini Maryam , Abdollahi Morteza , Eini-Zinab Hassan , Amirhamidi Zeinab , Esfandiari Saeed , Nutbeam Don 
Published: July 2018

Summary
This study used a locally designed and validated questionnaire to describe the distribution of food and nutrition literacy (FNLIT) in a cross-sectional sample of 803 students aged 10–12 years from elementary schools in Tehran city, Iran. Logistic regression was used to assess the extent to which various independent covariates were associated with low FNLIT. The data were used to identify significant differences using a range of social and cultural variables relevant to the context of school students in Iran. The results of the study showed that although the total FNLIT level was good, this headline finding masked important differences in the sub-domains. More than half of the children (69%) had high levels of FNLIT in the cognitive domain, but in the skills domain, very few (3%) scored highly. The study also identified some associations between the total FNLIT and its subscales and sociodemographic variables including gender, parent’s education and age, birth order. These results highlighted groups within the school population who were at higher risk of having lower FNLIT levels. They also indicate that girls feel more able to exert choice and control over food and nutrition decisions than boys are but may be less able to do so in practice. Overall, these results are a general reminder to schools of the different learning needs of children from different family backgrounds. The article highlights the need for continuous improvement in the health education curriculum of schools in Iran, particularly highlighting the importance of giving greater attention to the development of practical food and nutrition skills alongside more traditional food and nutrition knowledge. Additional studies (with long-term follow-up) are needed to more fully assess and understand the predictors of FNLIT.
Right Retrosigmoid Approach for In Situ Occlusion of Brainstem Arteriovenous Malformation Surrounding the Trigeminal Nerve: 3-Dimensional Operative Video
Authors: Rubio Roberto Rodriguez , Vigo Vera , Bonaventura Rina Di , Abla Adib A 
Published: July 2018

Abstract
Arteriovenous malformations (AVMs) of the trigeminal root entry zone are rare and can be associated with neurovascular compression syndromes as well as intracranial hemorrhage.
1
They generally have a small nidus located on and around the pial surface of the brainstem; thus, they are feasible for surgery. Nevertheless, they represent a challenge given the vicinity and involvement of cranial nerves and brainstem perforators.
2–4

This video demonstrates the case of a 57-yr-old man with new onset of a severe headache without neurological deficit associated with MRI evidence of a vascular malformation around the cisternal right trigeminal nerve. The nerve showed an altered signal on the MRI. Angiography revealed a Spetzler–Martin grade II AVM with a 16-mm nidus supplied by basilar artery perforators, right anterior inferior cerebellar artery, and the superior cerebellar artery (SCA), with drainage into the superior petrosal vein and sigmoid sinus. After an unsuccessful attempted embolization, the patient was referred for and elected microsurgical treatment. With the patient in a lateral position, a right retrosigmoid approach was performed. After cisternal dissection and identification of the nidus, the feeders were occluded by alternating cauterization and clipping to avoid damage to the critical surrounding structures. The AVM in-situ occlusion was carried on without resection, given the involvement of the trigeminal nerve. The intraoperative indocyanine green angiography allowed recognition of the venous drainage and helped to localize and differentiate the feeders from normal perforators. In the immediate postoperative course, the patient suffered from mild numbness with a V2-V3 distribution that progressively improved. Angiography showed no residual AVM.
Photometric investigation of the contact binary GU Orionis with high metallicity
Authors: Zhou Xiao , Qian Shengbang , Boonrucksar Soonthornthum , Poshyachinda Saran , Zhu Li-Ying , Liu Nian-Ping , Sarotsakulchai Thawicharat , Fang Xiao-Hui 
Published: July 2018

Abstract
GU Ori was observed with the 1 m telescope at Yunnan Observatories in 2005. To determine its physical properties, the Wilson–Devinney program was used. The results reveal that GU Ori is a W-subtype shallow contact binary with a more massive but cooler second star. The masses of its two component stars are estimated to be M1 = 0.45 M⊙, M2 = 1.05 M⊙. The O’Connell effect was reported to be negative on the light curves observed in 2005. However, it changed to a positive one on the light curves observed from 2011 to 2012. The mean surface temperatures of star 2 (T2) determined by the two sets of light curves were different, which may result from stellar activity. The O − C diagram shows that the period of GU Ori is decreasing at a rate of dP/dt = −6.24 × 10−8d yr−1, which may be caused by mass transfer from star 2 to star 1 with a rate of ${dM_{2}}/{dt}= - 2.98\times {10^{-8}}\, M_{\odot }$ yr−1. GU Ori is a contact binary with quite high metallicity.
Physical Therapy Services for People With Intellectual and Developmental Disabilities: The Role of Medicaid Home- and Community-Based Service Waivers
Authors: Friedman Carli , Feldner Heather A 
Published: July 2018

Abstract

Background
Care and support for people with intellectual and developmental disabilities (IDD) in natural community contexts are increasing. Many people with IDD use physical therapy services to support their community participation. Medicaid Home- and Community-Based Services (HCBS) 1915(c) waivers are the largest providers of long-term services and supports for people with IDD. However, little is known about physical therapy provision under this program.

Objective
The aim of this study was to compare the operational definitions of physical therapy service under the HCBS 1915(c) waiver system and to describe projected physical therapy service utilization, spending, and reimbursement for people with IDD across states.

Design
This was a cross-sectional, descriptive study.

Methods
This study analyzed fiscal year 2015 HCBS IDD waivers from across the nation (N = 111), focusing on physical therapy utilization (total projected spending, total participants, reimbursement rates, and average annual service provision per participant). Service definitions were also analyzed to determine trends across waivers.

Results
Fifty-one waivers (45.9%) provided 61 different types of physical therapy services in fiscal year 2015. States utilized waivers to provide long-term remedial care rather than the acute short-term physical therapy. HCBS waiver physical therapy services were often provided in participants’ homes and communities to expand physical therapy access and secure the benefits of providing physical therapy services in natural environments. Although most states have adopted similar definitions of physical therapy service, procedures and services vary.

Limitations
Medicaid HCBS waivers are state projections made to the federal government rather than actual utilization data.

Conclusions
Physical therapy service definitions, projected service utilization, spending, and reimbursement for people with IDD who use Medicaid HCBS waivers vary greatly between states. Physical therapy may be utilized less than expected given the reported benefits for people with IDD.