bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of age‐appropriate pre‐operative information session on the anxiety level of school‐age children undergoing elective surgery in Jordan
Authors: Shaheen Abeer , Nassar Omayyah , Khalaf Inaam , Kridli Suha Al‐Oballi , Jarrah Samiha , Halasa Suhaila 
Published: March 2018

AbstractBackgroundUndergoing surgery is an anxious experience for children. Applying anxiety reduction age‐appropriate programs by nurses would be beneficial in reducing anxiety to children.AimTo test the effectiveness of age‐appropriate preoperative information session in reducing anxiety levels of school‐age children undergoing elective surgery in Jordan.DesignThe study used a quasi‐experimental design.MethodsOne hundred and twenty‐six children were recruited from an educational hospital in Amman from January to June 2012 and were randomly assigned to intervention and control groups. The anxiety levels of children were assessed using the State Anxiety Scale for children, and children's levels of cooperation after surgery were assessed using Children Emotional Manifestation Scale. The heart rate and blood pressure of children were also measured 1 hour before going to operation room.ResultsThe study results revealed that children in the intervention group reported lower anxiety levels and more cooperation than children in the control group. Also, they displayed lower heart rate and blood pressure than children in the control group.ConclusionThe application of age‐appropriate preoperative intervention for children could be beneficial in decreasing anxiety levels and increasing their cooperation post surgery.
Association between demographics and resilience – a cross‐sectional study among nurses in Singapore
Authors: Ang S.Y. , Uthaman T. , Ayre T.C. , Mordiffi S.Z. , Ang E. , Lopez V. 
Published: March 2018

AimTo give an overview of the level of resilience among nurses in Singapore and to examine associations between various demographics variables and resilience level.BackgroundThe World Health Organization reported a global needs‐based shortage of over 9 million nurses and midwives in 2013. Building resilience among nurses has been postulated as one of the ways to support and retain nurses in the profession.MethodA self‐reported questionnaire consisting of questions on demographics and the Connor–Davidson Resilience Scale CD‐RISC 10 was used.ResultsUnivariate analysis identified marital status, age group, years of experience in nursing, highest education qualification and job grade to have significant associations with resilience. During multivariate analysis, only marital status, age group, highest educational qualification and job grade remained significant. A strong association was found between highest educational qualification and resilience level; nurses with bachelor's or postgraduate degree were about three times more likely than nurses with only a general nursing certificate to be of moderate/high resilience.ConclusionThe experience of life events (as exemplified by marital status, age and working experience) was associated with higher resilience levels.Implications for nursing policyThere is a need for healthcare organizations and nurse leaders to develop programmes focusing on building resilience among younger and less experienced nurses. Nurses should also be supported in their pursuits for higher education, which will in turn lead to higher resilience, and consequently, retention of nurses within the profession and institution.
Proxy decision making and dementia: Using Construal Level Theory to analyse the thoughts of decision makers
Authors: Convey Helen , Holt Janet , Summers Barbara 
Published: March 2018

AbstractAimsThis study explored the feasibility of using Construal Level Theory to analyse proxy decision maker thinking about a hypothetical ethical dilemma, relating to a person who has dementia.BackgroundProxy decision makers make decisions on behalf of individuals who are living with dementia when dementia affects that individual's decision making ability. Ethical dilemmas arise because there is a need to balance the individual's past and contemporary values and views. Understanding of how proxy decision makers respond is incomplete. Construal Level Theory contends that individuals imagine reactions and make predications about the future by crossing psychological distance. This involves abstract thinking, giving meaning to decisions. There is no empirical evidence of Construal Level Theory being used to analyse proxy decision maker thinking. Exploring the feasibility of using Construal Level Theory to understand dementia carer thinking regarding proxy decisions may provide insights which inform the support given.DesignDescriptive qualitative research with semi‐structured interviews.MethodsSeven participants were interviewed using a hypothetical dementia care scenario in February 2016. Interview transcripts were analysed for themes. Construal Level Theory was applied to analyse participant responses within themes using the Linguistic Category Model.ResultsParticipants travelled across psychological distance, using abstract thinking to clarify goals and provide a basis for decisions. When thinking concretely participants established boundaries regarding the ethical dilemma.ConclusionConstrual Level Theory gives insight into proxy decision maker thinking and the levels of abstraction used. Understanding what dementia carers think about when making proxy decisions may help nurses to understand their perspectives and to provide appropriate support.
Gender differences for growth in North American Atlantic salmon
Authors: Schaeffer L. , Tosh J. J. , Ang K.P. , Elliott J.A.K. , Herlin M. , Powell F. , Boulding E. G. 
Published: March 2018

SummaryAn assumption in aquaculture of Atlantic salmon is that male and female growth within families is perfectly genetically correlated. That is, families would rank identically if based on male growth only or female growth only. Also, growth in freshwater and sea water is assumed to be highly correlated between males and females within families. However, structural analysis of the DNA of Atlantic salmon has found that the linkage maps of females differ significantly from that of males. Genetic variability for any trait measured on females could be greater or lesser than on males. Thus, male and female growth might be considered as separate traits giving rise to families ranking differently depending on gender. A multiple trait family model for weight and length at 3 years of age in Atlantic salmon according to gender was applied to data on North American Atlantic salmon obtained from the Oak Bay Hatchery in New Brunswick, Canada. Genetic correlations between male and female growth in both freshwater and sea water were estimated by Bayesian methods. The estimates support the possible existence of gender dimorphism in North American Atlantic salmon for growth traits.
Noctural dipping status and left ventricular hypertrophy: A cardiac magnetic resonance imaging study
Authors: Rodrigues Jonathan C. L. , Amadu Antonio Matteo , Ghosh Dastidar Amardeep , Harries Iwan , Burchell Amy E. , Ratcliffe Laura E. K. , Hart Emma C. , Hamilton Mark C. K. , Paton Julian F. R. , Nightingale Angus K. , Manghat Nathan E. 
Published: March 2018

We investigate the impact of dipper status on cardiac structure with cardiovascular magnetic resonance (CMR). Ambulatory blood pressure monitoring and 1.5T CMR were performed in 99 tertiary hypertension clinic patients. Subgroup analysis by extreme dipper (n = 9), dipper (n = 39), non‐dipper (n = 35) and reverse dipper (n = 16) status was performed, matched in age, gender and BMI. Left ventricular (LV) mass was significantly higher for extreme dippers than dippers after correction for covariates (100 ± 6 g/m2 vs 79 ± 3 g/m2, P = .004). Amongst extreme dippers and dippers (n = 48), indexed LV mass correlated positively with the extent of nocturnal blood pressure dipping (R = .403, P = .005). On post‐hoc ANCOVA, the percentage of nocturnal dip had significant effect on indexed LV mass (P = .008), but overall SBP did not (P = .348). In the tertiary setting, we found a larger nocturnal BP drop was associated with more LV hypertrophy. If confirmed in larger studies, this may have implications on nocturnal dosing of anti‐hypertensive medications.
HMQ‐T‐F2 exert antitumour effects by upregulation of Axin in human cervical HeLa cells
Authors: Dai Bingling , Yang Tianfeng , Ma Yujiao , Ma Nan , Shi Xianpeng , Zhang Dongdong , Zhang Jie , Zhang Yanmin 
Published: March 2018

AbstractLooking for novel, effective and less toxic therapies for cervical cancer is of significant importance. In this study, we reported that HMQ‐T‐F2(F2) significantly inhibited cell proliferation and transplantable tumour growth. Mechanistically, HMQ‐T‐F2 inhibited HeLa cell growth through repressing the expression and nuclear translocation of β‐catenin, enhancing Axin expression, as well as downregulating the Wnt downstream targeted proteins. Knock‐down of a checkpoint β‐catenin by siRNA significantly attenuated HeLa cell proliferation. Furthermore, XAV939, an inhibitor of β‐catenin, was used to treat HeLa cells and the results demonstrated that HMQ‐T‐F2 inhibited proliferation and migration via the inhibition of the Wnt/β‐catenin pathway.
WDR79 mediates the proliferation of non‐small cell lung cancer cells by regulating the stability of UHRF1
Authors: Chen Jieying , Sheng Xunan , Ma Hongchang , Tang Zhengshan , Yang Chao , Cao Lanqin , Sun Yang , Deng Tanggang , Feng Peifu , Hu Bin , Wei Dong , Liu Jing , Xiong Wei , Ye Mao 
Published: March 2018

AbstractWD repeat protein 79 (WDR79) is a member of the WD‐repeat protein family characterized by the presence of a series of WD‐repeat domains and is a scaffold protein that participates in telomerase assembly, Cajal body formation and DNA double strand break repair. Although previous studies have revealed that WDR79 is frequently overexpressed in non‐small cell lung cancer (NSCLC) and promotes the proliferation of NSCLC cells, the underlying mechanism responsible for WDR79‐mediated NSCLC proliferation is not fully understood. In this study, we report a novel molecular function of WDR79 that mediates NSCLC cell proliferation by controlling the stability of UHRF1. In the nucleus, WDR79 colocalized and interacted with UHRF1. As a result, overexpression of WDR79 stabilized UHRF1, whereas ablation of WDR79 decreased the level of UHRF1. Meanwhile, we showed that WDR79 can protect UHRF1 from poly‐ubiquitination‐mediated proteolysis, which facilitated the stabilization of UHRF1. We further demonstrated that WDR79 exerts a proliferation effect on NSCLC cells by stabilizing UHRF1. These findings reveal that WDR79 is a novel UHRF1 regulator by maintaining UHRF1 stability, and they also provide a clue as to how to explore WDR79 for potential therapeutic application in NSCLC.
MicroRNA‐146a and microRNA‐155 as novel crevicular fluid biomarkers for periodontitis in non‐diabetic and type 2 diabetic patients
Authors: Radović Nikola , Nikolić Jakoba Nataša , Petrović Nina , Milosavljević Aleksandra , Brković Božidar , Roganović Jelena 
Published: March 2018

AbstractAimRecent studies point at the crucial role of epigenetic mechanisms in the development of multifactorial diseases such as periodontitis and diabetes mellitus (DM) type 2. In addition, circulatory microRNAs (miRs) have emerged as novel biomarkers for various diseases. Aim of this study was to investigate the levels of miR‐146a and miR‐155 and superoxide dismutase (SOD) activity in gingival crevicular fluid (GCF) of periodontitis patients with (CPDM) and without (CP) DM type 2 as well as in periodontally healthy, control groups (PHDM and PH, respectively).Material and methodsmiR modulation was analysed using quantitative real‐time PCR while SOD activity was measured spectrophotometrically.ResultsThe upregulation of miR‐146a and miR‐155 was observed in CP and CPDM patients’ baseline, while the levels decreased after 6 weeks of the non‐surgical therapy to the levels comparable to PH and PHDM, respectively. Expression levels of miRs positively correlated with SOD activity. Levels of miR‐146a were higher in PHDM compared to PH patients. Multivariate analysis revealed that levels of miR‐146a and miR‐155 were significantly associated with periodontitis when adjusting for age and gender.ConclusionsmiR‐146a and miR‐155 may be considered as possible novel biomarkers for periodontitis in non‐diabetic and type 2 diabetic patients.
How fundamental aspects of nursing care are defined in the literature: A scoping review
Authors: Feo Rebecca , Kitson Alison , Conroy Tiffany 
Published: March 2018

Aims and objectivesTo investigate how fundamental aspects of nursing care have been defined in the literature from 2010–2016.BackgroundA 2010 narrative review of nursing texts identified little consensus on what constitutes the fundamental aspects of nursing care. Since then there has been a proliferation of policies, strategic frameworks and research teams dedicated to investigating such care. It is unclear whether this increased activity has led to greater conceptual clarity.DesignScoping review using the Joanna Briggs Institute methodology.MethodsA search of published and grey literature was undertaken using CINAHL, Scopus, PubMed and ProQuest. Documents providing a definition for fundamental aspects of nursing care were included for review. Definitions were identified and mapped.ResultsForty‐nine documents were included. Two ways of constructing the discourse around fundamental aspects of nursing care were identified: compassionate care (n = 25) and fundamentals of care (n = 24). The literature on compassionate care focused primarily on the moral attributes of nurses and their ability to establish meaningful connections with patients. The literature on fundamentals of care was split between describing such care as a list of nursing activities and describing it as a complex, multidimensional construct.ConclusionsThere appears to be a lack of consensus around how fundamental aspects of nursing care are defined. Compassionate care and fundamentals of care have commonalities in terms of emphasising the nurse–patient relationship; however, only the literature on fundamentals of care addresses patients’ physical care needs. Despite their commonalities, it seems the two bodies of work are being developed largely independent of one another.Relevance to clinical practiceThis scoping review identified areas of convergence and divergence around fundamental aspects of nursing care. An agreed definition for such care is needed to enable the development of a robust evidence base to underpin the coherent and consistent development of nursing practice.
Perceived caring attributes and priorities of preregistration nursing students throughout a nursing curriculum underpinned by person‐centredness
Authors: Cook Neal F. , McCance Tanya , McCormack Brendan , Barr Owen , Slater Paul 
Published: March 2018

Aim and objectiveTo explore preregistration nursing students’ caring attributes development through a person‐centred focused curriculum.BackgroundDeveloping caring attributes in student nurses to the point of registration has historically been challenging. Globally, curricula have not yet demonstrated the ability to sustain and develop caring attributes in this population, despite its centrality to practice.Design and methodsThis longitudinal cohort study tracked how University preregistration nursing students (N = 212) developed their caring attributes over the 3 years of their programme using repeated measures at the end of each year with the same cohort. The Caring Dimensions Inventory (35 item version with 25 caring items under three constructs (technical, intimacy and supporting) and 10 inappropriate or unnecessary construct items) was used and data analysed using Mokken scale analysis to create a hierarchy of actions that students deemed as caring. Repeated measures of analysis of variance enabled evaluation of changes in responses over time.ResultsStudents developed their caring attributes throughout their programme, ranking 22 of 25 items as caring (with statistical significance) at the end of year 1, 18 at the end of year 2 and all 25 caring items at the end of their final year. No unnecessary or inappropriate construct items were ranked as caring at any data collection point. Participants consistently ranked assisting a person with an activity of living, listening to a patient and involving them in their care as the most caring actions.ConclusionThis study found caring attributes can not only be sustained, but can also be developed throughout a preregistration nursing education programme grounded in person‐centredness.Relevance to clinical practice

Internationally, caring attributes are challenging to develop and sustain throughout preregistration education, largely being diminished over time.

Little published evidence evidences how person‐centred frameworks are successfully integrated into preregistration nursing curricula to develop person‐centred nurses.
Marital relationship and health‐related quality of life of patients with prostate cancer and their spouses: A longitudinal clinical study
Authors: Harju Eeva , Rantanen Anja , Helminen Mika , Kaunonen Marja , Isotalo Taina , Åstedt‐Kurki Päivi 
Published: March 2018

Aims and objectivesTo examine changes in the marital relationship 6 months after the diagnosis and the effects of these changes on the health‐related quality of life of the patients with prostate cancer and their spouses.BackgroundThere is limited knowledge on the impact of a diagnosis of prostate cancer on the marital relationship and health‐related quality of life of patients and their spouses.DesignSurvey with longitudinal descriptive and comparative elements.MethodsOf 350 recruited couples (N = 700), 186 couples (n = 372) completed the Marital Questionnaire and RAND 36‐Item Health Survey at the two measurement points: time of diagnosis and 6 months later. Changes in the marital relationship were analysed statistically using descriptive statistics and nonparametric tests. The influence of changes in the marital relationship on health‐related quality of life was evaluated using linear regression analyses.ResultsThe patients and their spouses reported lower marital satisfaction 6 months after the diagnosis than at the time of diagnosis. The summary score for marital satisfaction of the spouses significantly decreased during the follow‐up period. In contrast, decreasing changes in the marital relationship of the patients were not statistically significant. Furthermore, the marital relationship of the patients and their spouses was not statistically significantly associated with changes in the health‐related quality of life of the patients and their spouses within 6 months.ConclusionsThe results of this study add to current knowledge of the marital relationship of patients with prostate cancer and their spouses. The spouses reported that their marital relationship had suffered, whereas the patients reported that the marital relationship remained unchanged.Relevance to clinical practiceThese findings may be useful when counselling of patients with prostate cancer and their spouses.
Exploring the need for Transition Readiness Scales within cystic fibrosis services: A qualitative descriptive study
Authors: Bourke Mary , Houghton Catherine 
Published: March 2018

Aims and objectivesTo explore healthcare professionals’ and patients’ perceptions of the potential use of a Transition Readiness Scale in cystic fibrosis care. This included an examination of barriers and facilitators to its implementation along with the identification of key items to include in a Transition Readiness Scale.BackgroundDue to increasing life expectancy and improved quality of life, more adolescents with cystic fibrosis are transitioning from paediatric to adult health care. To assess and correctly manage this transition, a more structured approach to transition is advocated. This can be achieved using a Transition Readiness Scale to potentially identify or target areas of care in which the adolescent may have poor knowledge. These key items include education, developmental readiness taking into account relationships, reproduction, future plans and self‐management skills. Existing tools to gauge readiness concentrate mainly on education and self‐care needs assessment as their key items. Currently, there is no specific cystic fibrosis Transition Readiness Scale in use in Ireland or internationally.DesignThe study used a descriptive qualitative design.MethodsData were collected using semi‐structured interviews (n = 8) and analysed using a thematic approach.ResultsThe findings identified the potential benefits of this tool and second the resources which need to be in place before its development and implementation into cystic fibrosis services.ConclusionTransition Readiness Scales have substantial relevance with cystic fibrosis services emphasising the importance of establishing the necessary resources prior to its implementation. These were identified as more staff, a dedicated private space and staff training and education.Relevance to Clinical PracticeSignificant resources are needed to fully integrate Transition Readiness Scales in practice. The study findings suggest multidisciplinary collaborations, and patient engagement is pivotal in planning and easing the transition process for adolescents with cystic fibrosis.
A literature review of comfort in the paediatric critical care patient
Authors: Bosch‐Alcaraz Alejandro , Falcó‐Pegueroles Anna , Jordan Iolanda 
Published: March 2018

Aims and objectivesTo investigate the meaning of comfort and to contextualise it within the framework of paediatric critical care.BackgroundThe concept of comfort is closely linked to care in all health contexts. However, in specific settings such as the paediatric critical care unit, it takes on particular importance.DesignA literature review was conducted.MethodsA literature search was performed of articles in English and Spanish in international health science databases, from 1992–March 2017, applying the quality standards established by the PRISMA methodology and the Joanna Briggs Institute.ResultsA total of 1,203 publications were identified in the databases. Finally, 59 articles which met the inclusion criteria were entered in this literature review. Almost all were descriptive studies written in English and published in Europe. The concept of comfort was defined as the immediate condition of being strengthened through having the three types of needs (relief, ease and transcendence) addressed in the four contexts of experience (physical, psychospiritual, social and environmental). Only two valid and reliable tools for assessing comfort were found: the Comfort Scale and the Comfort Behavior Scale.ConclusionsComfort is subjective and difficult to assess. It has four facets: physical, emotional, social and environmental. High levels of noise and light are the inputs that cause the most discomfort. Comfort is a holistic, universal concept and an important component of quality nursing care.