bluuebunny/crossref_metadata_2025_split huggingface dataset:
Looking forward: anticipation enhances service experiences
Authors: Polegato Rosemary , Bjerke Rune 
Published: April 2019

Purpose
This paper aims to explore the nature and relationships among the dimensions that constitute expectations, anticipation and post-experience assessment of cultural events, before and after an aesthetic experience, namely, a live Norwegian opera or ballet performance.

Design/methodology/approach
A triangulation approach is used to combine qualitative and quantitative analyses. Quantitative data collection was conducted at the site before and after a performance experience.

Findings
Expectations, anticipation and post-experience assessment are found to be multi-dimensional. Expectations and anticipation are identified as distinct constructs. Three dimensions of expectations of quality are extrinsic cues: building and functional attributes, available services and level of employee service. In addition, two dimensions of pre-experience anticipation are identified: anticipation of information gathering activities and anticipation of the event. Post-experience assessment has two dimensions: satisfaction and pride in the building. Two post-experience associations are enthusiasm and inclusiveness. Anticipation of the event and enthusiasm, not expectations, are found to be predictors of satisfaction.

Research limitations/implications
An understanding of the role of anticipation in consumer engagement and satisfaction with aesthetic experiences could be broadened and enriched by studies that include other service or arts disciplines and within a more complex model of consumer engagement.

Originality/value
Anticipation is a significant pre-experience phenomenon. Enthusiasm is identified as a post-experience association.
Creating social value through entrepreneurship: the social business model of La Paranza
Authors: Canestrino Rossella , Ćwiklicki Marek , Di Nauta Primiano , Magliocca Pierpaolo 
Published: April 2019

PurposeThe purpose of this paper is to identify the key factors for successful creation of social value using the social business model (SBM) as an explanatory framework.Design/methodology/approachThis study follows the Krippendorff and Gioia’s methodology seeking the rigor while examining the selected case study – a social cooperative named La Paranza, in the city of Naples in the south of Italy. In doing so, the SBM canvas is used to present the research’s results in a systematic way.FindingsThe existence of a strong “identity” with the local context, the “enthusiasm and the wish to change things”, the presence of a “visionary”, acting as an orchestrator and the ability to provide for responses to the local needs were identified as key factors in the successful creation of social value in the examined case.Research limitations/implicationsThe main research limits stem from the single case study methodology approach, which embodies the researchers’ subjectivity. A comparative study based on the collection of multiple successful case studies is therefore suggested to develop a generalization of the key drivers underlying the process of social value creation.Originality/valueThe study’s originality results from its use of the SBM framework in presenting a successful example of social value creation. The examined empirical evidence is also original in itself, mainly because of its inner uniqueness as a new and innovative formula: this allows an in-depth investigation and the inspiration for new ideas in the ground of SBM and, in a broader sense, in the field of social innovation and social value creation.
Communication networks, externalities, and the price of information
Authors: Polanski Arnold 
Published: April 2019

AbstractInformation goods (or information for short) play an essential role in modern economies. We consider a setup where information has some idiosyncratic value for each consumer, exerts externalities, and can be freely replicated and transmitted in a communication network. Prices paid for information are determined via the (asymmetric) Nash Bargaining Solution with endogenous disagreement points. This decentralized approach leads to unique prices and payoffs in any exogenous network. We use these payoffs to find connection structures that emerge under different externality regimes in pre‐trade network formation stage. An application to citation graphs results in eigenvector‐like measures of intellectual influence.
How can the public trust charities? The role of performance accountability reporting
Authors: Yang Cherrie , Northcott Deryl 
Published: April 2019

AbstractCharities rely on public trust to exist. However, that trust has diminished, with a perceived lack of accountability seen as a key reason. This study draws on case studies of two New Zealand charities to examine their performance accountability reporting practices and potential implications for public trust. The findings surface the day‐to‐day agency of charity actors in shifting performance accountability practices towards modes of disclosure that are relevant and accessible to the public. This paper contributes to the literature by extending understandings of how charities produce accountability information that can enhance public trust and, thus, support their mission achievement.
Identification of disease‐causing variants in the EXOSC gene family underlying autosomal recessive intellectual disability in Iranian families
Authors: Beheshtian Maryam , Fattahi Zohreh , Fadaee Mahsa , Vazehan Raheleh , Jamali Payman , Parsimehr Elham , Kamgar Mahboubeh , Zonooz Mehrshid Faraji , Mahdavi Shokouh Sadat , Kalhor Zahra , Arzhangi Sanaz , Abedini Seyedeh Sedigheh , Kermani Farahnaz Sabbagh , Mojahedi Faezeh , Kalscheuer Vera M. , Ropers Hans‐Hilger. , Kariminejad Ariana , Najmabadi Hossein , Kahrizi Kimia 
Published: April 2019

AbstractNeurodevelopmental delay and intellectual disability (ID) can arise from numerous genetic defects. To date, variants in the EXOSC gene family have been associated with such disorders. Using next‐generation sequencing (NGS), known and novel variants in this gene family causing autosomal recessive ID (ARID) have been identified in five Iranian families. By collecting clinical information on these families and comparing their phenotypes with previously reported patients, we further describe the clinical variability of ARID resulting from alterations in the EXOSC gene family, and emphasize the role of RNA processing dysregulation in ARID.
SOX‐10 staining in dermal scars
Authors: Behrens Emily L. , Boothe William , D'Silva Nerissa , Walterscheid Brooke , Watkins Philip , Tarbox Michelle 
Published: April 2019

AbstractBackgroundPositive staining for SOX10 and the S100 protein are often used in the evaluation of challenging melanocytic neoplasms including melanoma in patient samples. SOX‐10 positivity of non‐melanocytes in re‐excision specimen could complicate the evaluation of invasive melanoma with an invasive desmoplastic component. Therefore, quantifiable data regarding the positivity of SOX‐10 in scars will help dermatopathologists to better identify false positive staining.MethodsA retrospective analysis was performed on 50 re‐excision specimens from 2013 to 2017, with a diagnosis of squamous cell carcinoma (SCC) or squamous cell carcinoma in situ (SCCIS). Blocks of re‐excision specimens containing scars were stained for SOX‐10; results were evaluated by a board‐certified dermatopathologist. The sum of the five highest numbers of high‐power field (HPF) counts as a proxy for “SOX‐10 stain factor,” and cell morphological features were analyzed. MART‐1 and CD68 immunohistochemical staining was performed to study possible lineage of these SOX‐10 positive cells.ResultsAll 50 specimens showed varying degrees of SOX‐10 positivity for histiocytes. SOX‐10 positive histiocytes were present in 86% of re‐excision scar tissues, of which 71.3% had spindle‐shaped or angulated nuclei, and 61.8% had nuclear sizes larger than typical lymphocytes (7 μm). Within the same area of scars, CD68 staining was floridly positive, where as MART‐1 staining was overwhelmingly negative.ConclusionsThis study illustrates a potential diagnostic pitfall of using SOX‐10 to evaluate re‐excision specimens of melanocytic neoplasms and also suggests a previously undescribed staining pattern in scars of SOX‐10 positive cells that are not melanocytes. We postulate that such SOX‐10 positive cells may represent a small fraction of histiocytes routinely found in scar tissue.
SDF‐1/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception
Authors: Dimova Ivanka , Karthik Swapna , Makanya Andrew , Hlushchuk Ruslan , Semela David , Volarevic Vladislav , Djonov Valentin 
Published: April 2019

AbstractThe precise mechanisms of SDF‐1 (CXCL12) in angiogenesis are not fully elucidated. Recently, we showed that Notch inhibition induces extensive intussusceptive angiogenesis by recruitment of mononuclear cells and it was associated with increased levels of SDF‐1 and CXCR4. In the current study, we demonstrated SDF‐1 expression in liver sinusoidal vessels of Notch1 knockout mice with regenerative hyperplasia by means of intussusception, but we did not detect any SDF‐1 expression in wild‐type mice with normal liver vessel structure. In addition, pharmacological inhibition of SDF‐1/CXCR4 signalling by AMD3100 perturbs intussusceptive vascular growth and abolishes mononuclear cell recruitment in the chicken area vasculosa. In contrast, treatment with recombinant SDF‐1 protein increased microvascular density by 34% through augmentation of pillar number compared to controls. The number of extravasating mononuclear cells was four times higher after SDF‐1 application and two times less after blocking this pathway. Bone marrow‐derived mononuclear cells (BMDC) were recruited to vessels in response to elevated expression of SDF‐1 in endothelial cells. They participated in formation and stabilization of pillars. The current study is the first report to implicate SDF‐1/CXCR4 signalling in intussusceptive angiogenesis and further highlights the stabilizing role of BMDC in the formation of pillars during vascular remodelling.
Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/HO‐1 and AMPK signalling pathways
Authors: Shen Bingyu , Zhao Chenxu , Wang Yue , Peng Yi , Cheng Jiaqi , Li Zheng , Wu Lin , Jin Meiyu , Feng Haihua 
Published: April 2019

AbstractAucubin (AU) is the main active ingredient of Aucuba japonica which has showed many positive effects such as anti‐inflammation and liver protection. Non‐alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. In this research, we explored the effects of AU on the tyloxapol‐induced NAFLD in mice and apolipoprotein C‐III (apoC‐III) induced‐3T3L1 cells. Tyloxapol (300 mg/kg) was injected to C57BL/6 mice with aucubin. The differentiated 3T3‐L1 cells were treated with or without aucubin after stimulation of apoC‐III (100 μg/mL). In results, aucubin inhibited hyperlipidaemia, oxidative stress and inflammation by influencing the content of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), myeloperoxidase (MPO), superoxide dismutase (SOD), tumour necrosis factor receptor‐α (TNF‐α), interleukin‐1β (IL‐1β), and IL‐6 in blood. AU activated NF‐E2‐related factor 2 (Nrf2), peroxisome proliferator‐activated receptor α (PPARα), PPARγ and hemeoxygenase‐1 (HO‐1) and promoted the phosphorylation of adenosine 5′‐monophosphate‐activated protein kinase (AMPKα), AMPKβ, acetyl‐CoA carboxylase (ACC) and protein kinase B (AKT). In conclusion, AU performed the function of hypolipidaemic by its obvious anti‐inflammation and antioxidant activity, which may become a kind of new drug targeting at NAFLD.
The role of insulin in transdifferentiated hepatocyte proliferation and function in serum‐free medium
Authors: Gu Ce , Li Panpan , Liu Wei , Zhou Yan , Tan Wen‐Song 
Published: April 2019

AbstractTransdifferentiated hepatocytes are potential seeding cells for bioartificial liver (BAL) treatment, and it is important to obtain a sufficient number of functional hepatocytes in serum‐free medium (SFM). Although insulin plays an essential role in promoting cell proliferation and metabolism, the functions of insulin in transdifferentiated cells remain poorly understood. Here, we found that 1.0 mg/L insulin significantly increased human‐induced hepatocyte‐like cells (hiHeps) proliferation and viability in SFM. The pro‐proliferative effect of insulin on these cells occurred via augmented cyclin D1 expression that was mediated by activation of the Akt1/mTOR/p70S6K and Akt1/P53 pathways. Further studies revealed that insulin also enhanced the specific liver function of hiHeps in SFM. Additionally, Western blotting and siHNF1A transfection analysis showed that insulin increased the protein expression of Albumin (ALB) and UDP‐glucuronosyltransferase1A1 （UGT1A1 ） in hiHeps via HNF1A. Finally, hiHep proliferation and the expression of specific genes were maintained during long‐term passaging in SFM supplemented with 1.0 mg/L insulin. Collectively, our findings show that insulin promotes transdifferentiated hiHep proliferation and specific functional expression. These findings have important implications for the expansion of functional hiHeps prior to clinical applications of BALs.
The signature featureTM: A new concept in beauty
Authors: Shamban Ava 
Published: April 2019

SummarySignature FeatureTM (SF) is a universal, yet highly personalized treatment approach to aesthetic facial enhancement that applies to all patients, independent of age, gender, or ethnicity. Its philosophical basis maintains that a patient's beauty is anchored by their most distinctive invariant features (invariant features like eyes, nose, cheekbones, or jawline), and preservation of such signature features should be an essential consideration in any aesthetic treatment plan. The principles central to the SF concept include: (a) identifying the patient's most distinctive signature feature, (b) matching the patient's persona to their signature feature while preserving alignment with their cultural/ethnic aesthetic, and (c) highlighting the patient's signature feature by increasing the “signal‐to‐noise” ratio between the strength of the signature feature and those factors that may be interfering with it (lines, wrinkles, and sun damage). Every patient represents a new combination of treatment challenges which are not only related to the patient's physical baseline characteristics but also by their subjective self‐perceptions. This subjective gray area is where the SF treatment approach has the greatest contribution to the patient's positive self‐perception and self‐esteem, as the practitioner can help the patient realize their own personal brand through enhancement of their signature feature using an array of aesthetic options.
“It gave me so much confidence”: First‐time U.S. mothers' experiences with antenatal milk expression
Authors: Demirci Jill R. , Glasser Melissa , Fichner Jessica , Caplan Erin , Himes Katherine P. 
Published: April 2019

AbstractAntenatal milk expression (AME) involves maternal hand‐expression, collection, and storage of breast milk during pregnancy for the purposes of reducing the early formula use in breastfed infants. AME is not widely practiced in the United States, despite its growing popularity elsewhere. In this study, we examined the experiences of first‐time mothers recruited from a U.S. midwife practice who engaged in AME within the context of a pilot randomized controlled trial. The AME intervention involved demonstration and practice of AME with a lactation consultant beginning at 37 weeks of gestation, reinforcement at weekly study visits until delivery, and daily home practice. Nineteen women participated in a semistructured interview at 1–2 weeks postpartum regarding their study experiences. Major themes included (1) perceived benefits and impact of AME, (b) AME implementation, and (c) use of AME milk. Women perceived multiple benefits of AME, most notably that it increased their confidence that they would be able to make milk and breastfeed successfully postpartum. Women expressed some concern that no/little milk expressed could be indicative of postpartum milk production problems. Regarding implementation, women found that the AME protocol fit well into their daily routine. There was mixed feedback regarding comfort with practicing AME in the presence of partners. Reasons for postpartum use of AME milk varied; barriers to provision included inadequate milk storage options at the birth hospital and unsupportive hospital providers/staff. With few caveats, AME appears to be an acceptable breastfeeding support intervention among a sociodemographically homogeneous group of first‐time mothers in the United States.
Permanent Contributions in Philosophy
Authors: Lycan William G. 
Published: April 2019

AbstractHas any school or movement in all of Western philosophy made a permanent contribution, permanent in the sense that it will last as long as philosophy does? More narrowly, has there ever been put forward athesisthat has achieved lastingconsensus? After carefully defining “philosophical thesis” and “consensus,” so as to forestall uninteresting answers, this paper argues that the ancient Greeks made one or two such contributions, and the Analytic philosophers (ca. 1890–1960) made a few, but there have been no others. Moreover (a) the Analytic contributions were more empirical than philosophical, and (b) they were almost entirely negative. So, the basic short answer to our question is “no.” The paper concludes by asking in what way(s) there has beenprogressin philosophy.
The Astounding Assumption of Infinite Life
Authors: Miller Lantz Fleming 
Published: April 2019

AbstractThe multimillennial philosophical discussion about life after death has received a recent boost in the prospect of immortality attained via technologies. In this newer version, humans generally are considered mortal but may develop means of making themselves immortal. If “immortal” means not mortal, thus existing for infinity, and if the proposed infinite‐existing entity is material, it must inhabit an infinite material universe. If the proposed entity is not material, there must be means by which it can shed its material substance and exist nonmaterially. The article examines arguments for how an infinite life would be possible given current physical understanding. The paper considers a Pascalian‐style wager weighing the likelihood of adjusting to existence wholly within a finite universe versus betting on there being some way to construe the universe(s) as a viable medium for infinite beings. Conclusion: the case for a finite being to exist infinitely has little viable support.
Moral Relativism and Majority Rule
Authors: Wreen Michael 
Published: April 2019

AbstractA number of arguments against relativism are based on the concept of majority rule. Since, the arguments allege, on relativism moral truth is founded on majority opinion, relativism entails that (a) moral progress and reform are impossible, (b) propaganda, advertising, brainwashing, and high birth rates turn mistaken moral judgments into correct ones, (c) moral horrors, if enough people believe them acceptable, are not moral horrors at all, (d) finding out what’s right and what’s wrong is extremely easy, (e) moral reasoning is very different from what we normally take it to be, and (f) internal criticism of a moral code is impossible. These arguments get their due in this article, which first defines and explicates relativism and then exposes, explains, and criticizes the arguments. Especially important to understand about the relation between relativism and majority opinion is the notion of a convention. Accordingly, it is discussed at some length.
Ethno‐traditional nationalism and the challenge of immigration
Authors: Kaufmann Eric 
Published: April 2019

AbstractThe rise of the populist right in the West is emerging as the most discussed manifestation of nationalism in the world today. In this paper, I argue that this ‘new nationalism’ is largely driven by immigration, which affects ethnic majorities within nation‐states. This in turn alters the ethnic character of the nation, challenging what I term the ethno‐traditions of nationhood. Our inherited concepts of ethnic and civic nationalism were developed in an earlier period when immigration was limited and territorial revisionism animated nationalist movements. Only on the furthest reaches of the extreme right is the worldview one of ethnic nationalism. In our demographically churning yet territorially static western world, we need a new term to describe the cultural nationalism of the anti‐immigration right. I characterise this as ethno‐traditional nationalism, a variety of nationalism which seeks to protect the traditional preponderance of ethnic majorities through slower immigration and assimilation but which does not seek to close the door entirely to migration or exclude minorities from national membership.
What kind of nationalism sets the radical right and its electorate apart from the rest? Pride in the nation's history as part of nationalist nostalgia
Authors: Lubbers Marcel 
Published: April 2019

AbstractThis contribution concerns the nationalist ideology of the radical right and the kind of nationalism that prevails amongst its voters. The article addresses whether closeness to the nation, patriotism and chauvinism are relevant for people to be attracted to the radical right compared with competing parties or whether a reference to an out‐group perceived to harm (economic or cultural) interests is necessary for voters to opt for the radical right. The argument here is based on the ASEN lecture at the 2018 General Conference in London and sets forth a closer interest in nationalist nostalgia.
Resveratrol attenuates the pathogenic and inflammatory properties of Porphyromonas gingivalis
Authors: Ben Lagha Amel , Andrian Elisoa , Grenier Daniel 
Published: April 2019

Porphyromonas gingivalis has been strongly associated with chronic periodontitis, which affects tooth‐supporting tissues. This Gram‐negative anaerobic bacterium produces a repertoire of virulence factors that modulate tissue destruction directly or indirectly by the induction of inflammatory processes. The aim of this study was to investigate the effects of resveratrol, a major polyphenol found in grapes and wine, on the growth and virulence properties of P. gingivalis as well as on gingival keratinocyte tight junction integrity and the host inflammatory response. Resveratrol exhibited antibacterial activity that may result from damage to the bacterial cell membrane. Resveratrol also killed a pre‐formed P. gingivalis biofilm and reduced bacterial adherence to matrix proteins. In addition, resveratrol had a protective effect on the integrity of the keratinocyte tight junctions by inhibiting its breakdown by P. gingivalis. This may be related to the ability of resveratrol to inhibit the protease activities of P. gingivalis. Lastly, resveratrol reduced P. gingivalis‐mediated activation of the NF‐κB signaling pathway and attenuated TREM‐1 gene expression as well as soluble TREM‐1 secretion in monocytes. The effect on NF‐κB activation likely results from the ability of resveratrol to act as a PPAR‐γ agonist. In summary, the antibacterial, anti‐adherence, and antiprotease properties of resveratrol, as well as its ability to protect the gingival keratinocyte barrier and attenuate the inflammatory response in monocytes suggest that it may be a promising novel therapeutic agent for treating periodontal disease.