bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations Between Physical Therapy Continuity of Care and Health Care Utilization and Costs in Patients With Low Back Pain: A Retrospective Cohort Study
Authors: Magel John , Kim Jaewhan , Thackeray Anne , Hawley Charles , Petersen Sterling , Fritz Julie M 
Published: August 2018

Abstract

Background
Patients who consult a physical therapist for low back pain (LBP) may receive initial and subsequent management from different therapists. The impact that physical therapy provider continuity has on health care use in patients with LBP is insufficiently studied.

Objective
The objective of this study was to examine the impact of continuity of the physical therapy provider on health care use and costs in patients with LBP referred from primary care.

Design
The study design included a retrospective analysis of claims data.

Methods
Data from an all-payer claims database were examined. Logistic regression was used to evaluate the association between physical therapy provider continuity and health care use during the 1-year period following a visit with a primary care provider for LBP.

Results
Patients who experienced greater physical therapy provider continuity had a decreased likelihood of receiving lumbar surgery. They also paid less (mean = ${\$}$1737 [95% confidence interval, ${\$}$1602–${\$}$1871]) than those who experienced less physical therapy provider continuity (mean = ${\$}$2577 [95% confidence interval, ${\$}$2008–${\$}$3145]).

Limitations
The degree of causality between any predictor and outcome variables cannot be determined due to the observational nature of the study.

Conclusions
Greater continuity of the physical therapy provider appears to be associated with a decreased likelihood of surgical treatment for LBP and lower health care costs related to LBP.
Extended McKay correspondence for quotient surface singularities
Authors: Ishii Akira , Nakamura Iku 
Published: August 2018

Abstract
Let G be a finite subgroup of GL(2) acting on A2/{0} freely. The G-orbit Hilbert scheme G-Hilb(A2) is a minimal resolution of the quotient A2/G as given by A. Ishii, On the McKay correspondence for a finite small subgroup of GL(2,C), J. Reine Angew. Math. 549 (2002), 221–233. We determine the generator sheaf of the ideal defining the universal G-cluster over G-Hilb(A2), which somewhat strengthens a version [10] of the well-known McKay correspondence for a finite subgroup of SL(2).
Polyhedrality and Decomposition
Authors: Abrahamsen Trond A , Fonf Vladimir P , Smith Richard J , Troyanski Stanimir 
Published: August 2018

Abstract
The aim of this note is to present two results that make the task of finding equivalent polyhedral norms on certain Banach spaces, having either a Schauder basis or an uncountable unconditional basis, easier and more transparent. The hypotheses of both results are based on decomposing the unit sphere of a Banach space into countably many pieces, such that each one satisfies certain properties. Some examples of spaces having equivalent polyhedral norms are given.
Self-reported Balance Disturbance and Performance-Based Balance Impairment After Concussion in the General Population
Authors: Inness Elizabeth L. , Sweeny Michelle , Habib Perez Olinda , Danells Cynthia , Chandra Tharshini , Foster Evan , Saverino Cristina , Comper Paul , Bayley Mark , Mochizuki George 
Published: August 2018

Objective:
To characterize the prevalence of, and relationship between, self-reported balance disturbance and performance-based balance impairment in the general population with concussion.

Setting:
Rehabilitation hospital outpatient concussion clinic.

Participants:
One hundred six individuals with concussion (49 males, mean age = 32.4; SD = 11.5 years), mean (SD) = 5 (1.8) days postinjury.

Design:
Cross-sectional observational study.

Main Measures:
SCAT3 Symptoms Subscale, Balance Error Scoring System, modified Balance Error Scoring System, and center-of-pressure root-mean-square amplitude and velocity in eyes open and closed conditions.

Results:
The majority of participants reported balance or dizziness symptoms (54% and 63%, respectively) and demonstrated balance impairment on the Balance Error Scoring System and modified Balance Error Scoring System (66% and 58%, respectively). The prevalence of balance impairment across center-of-pressure measures varied from 32% to 48%. There was no effect of balance or dizziness symptom severity on any of the balance measures (F
2,103 = 1.02; P = .44) and (F
2,103 = 1.45; P = .10), respectively. There was poor agreement between self-report of balance/dizziness symptoms and identified balance impairment across all balance measures (all κ ≤ 0.26 and κ ≤ 0.20, respectively).

Conclusions:
There was no clear relationship between the subjective experience of balance disturbance and objective measures of balance impairment in the general population. These results have implications for clinical evaluation of postconcussive deficits and determination of recovery.
Late-Onset Microsporidial Keratitis in Femtosecond Astigmatic Keratotomy After Laser-Assisted Phacoemulsification
Authors: Grillo Lola M. , Epstein Ilan J. , Donnenfeld Eric D. , Perry Henry D. 
Published: August 2018

Purpose:
To present a case of microsporidial keratitis in a femtosecond laser–created astigmatic keratotomy (AK) incision.

Methods:
Case report.

Results:
A 65-year-old Middle Eastern man presented 2 months after uncomplicated femtosecond laser–assisted cataract surgery (FLACS) and AK with mildly decreased vision and corneal edema in the operative eye. Shortly after treatment with topical corticosteroids, a fulminant corneal infiltrate manifested along the temporal arcuate incision. Multiple corneal scrapings sent for laboratory analysis were inconclusive. Two weeks after the initial presentation, a deep tissue sample was obtained using a 27-gauge cannula passed within the arcuate incision. The gram stain was directly observed, revealing intracellular microsporidial spores. The patient was treated with oral albendazole 400 mg once daily over 2 weeks and topical voriconazole 1% and fumagillin 3 mg/mL eye drops over 10 weeks. During this course, visual function steadily recovered as the infiltrate coalesced and ocular inflammation subsided.

Conclusions:
This is the first reported case of microsporidial keratitis presenting as a late-onset infection after femtosecond laser–assisted AK.
Visualization of the Lamina Cribrosa Microvasculature in Normal and Glaucomatous Eyes: A Swept-source Optical Coherence Tomography Angiography Study
Authors: Numa Shogo , Akagi Tadamichi , Uji Akihito , Suda Kenji , Nakanishi Hideo , Kameda Takanori , Ikeda Hanako Ohashi , Tsujikawa Akitaka 
Published: August 2018

Purpose:
The purpose of this study was to investigate the lamina cribrosa (LC) microvasculature using swept-source optical coherence tomography angiography (OCTA) images that have been processed using multiple image averaging and a projection-resolved algorithm. OCTA has recently gained popularity for assessing retinal and choroidal microvasculature. However, it is not known if the LC microvasculature, which likely holds important information for further understanding of glaucoma, can be visualized with OCTA.

Methods:
One normal subject and 1 glaucomatous subject were enrolled and optic disc 3×3 mm swept-source OCTA cubic images were obtained for each subject. Anterior LC slab frames were developed, and the averaged images were created using 3 frames. Images were examined both with and without removal of projection artifacts.

Results:
The OCTA images of anterior LC slabs before projection artifact removal contained information on superficial and deep layer vessel blood flow. However, after projection artifact removal, fewer blood flow signals remained. These en face OCTA images showed flow signals on or immediately adjacent to lamina beams, but not inside lamina pores. The glaucomatous eye had a sectoral reduction in LC microvasculature blood flow that was not detected in normal eye.

Conclusions:
This is the first demonstration of imaging of the inner LC microvasculature, which, in agreement with previous histologic reports, was arranged in a polygonal pattern. Furthermore, glaucomatous eye had decreased flow signals in comparison with normal eye. Therefore, future imaging studies with OCTA may be helpful for identifying and better understanding LC pathologic changes associated with glaucoma.
A Case of Glaucoma in Hereditary Spherocytosis
Authors: Chen Haiying , Symons Robert C.A. , Mayson Eleni , Skalicky Simon E. 
Published: August 2018

Purpose:
To report a case of glaucoma and the inherited red cell membranopathy hereditary spherocytosis diagnosed simultaneously in 2 individuals in a family.

Patient:
A 66-year-old man with normal pressure glaucoma and hereditary spherocytosis.

Results:
This patient presented with a branch retinal vein occlusion, and normal tension glaucoma that was incidentally detected. Further history revealed that the patient’s maternal grandmother also had hereditary spherocytosis and glaucoma.

Conclusions:
We hypothesize that glaucoma and hereditary spherocytosis may be associated. Hereditary spherocytosis may be a potential risk factor for glaucoma by causing impaired blood supply to the optic nerve.
The Risk of Serious Bacterial Infection in Febrile Infants 0–90 Days of Life With a Respiratory Viral Infection
Authors: Nicholson Erin G. , Avadhanula Vasanthi , Ferlic-Stark Laura , Patel Kirtida , Gincoo Karen E. , Piedra Pedro A. 
Published: August 2018

Background:
Molecular diagnostic methods enhance the sensitivity and broaden the spectrum of detectable respiratory viruses in febrile infants ≤90 days of life. We describe the occurrence of respiratory viruses in this population, as well as the rates of serious bacterial infection (SBI) and respiratory viral coinfection with regard to viral characteristics.

Methods:
This was a prospective observational cohort study performed in the emergency department that included previously healthy febrile infants ≤90 days of life. Clinical and historical characteristics were documented, and a respiratory nasal wash specimen was obtained from each patient. This sample was tested for 17 common respiratory pathogens, and a chart review was conducted to ascertain whether the infant was diagnosed with an SBI.

Results:
In a 12-month period, 67% of the 104 recruited febrile infants were positive for a respiratory virus. The most commonly detected viruses were rhinovirus, respiratory syncytial virus, enterovirus and influenza. The rate of respiratory viral and SBI coinfection was 9% overall, and infants with either a systemic respiratory virus or negative viral testing were 3 times more likely to have an SBI than those with viruses typically restricted to the respiratory mucosa (95% confidence interval: 1.1, 9.7).

Conclusions:
Respiratory viruses are readily detectable via nasopharyngeal wash in febrile infants ≤90 days of life. With the enhanced sensitivity of molecular respiratory diagnostics, rates of coinfection of respiratory viruses and SBI may be higher than previously thought. Further investigation utilizing molecular diagnostics is needed to guide usage in febrile infants ≤90 days.
A Multi-Centered Case-Case-Control Study of Factors Associated With Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Infections in Children and Young Adults
Authors: Logan Latania K. , Nguyen David C. , Scaggs Huang Felicia A. , Qureshi Nadia K. , Charnot-Katsikas Angella , Bartlett Allison H. , Zheng Xiaotian , Hujer Andrea M. , Domitrovic T. Nicholas , Marshall Steven H. , Bonomo Robert A. , Weinstein Robert A. 
Published: August 2018

Background:

Klebsiella pneumoniae carbapenemase (KPC)–producing Enterobacteriaceae (KPC-CRE) are multidrug-resistant organisms causing morbidity and mortality worldwide. KPC-CRE prevalence is increasing in pediatric populations, though multi-centered data are lacking. Identifying risk factors for KPC-CRE infection in children and classifying genotypes is a priority in this vulnerable population.

Methods:
A case-case-control study of patients (0–22 years) at 3 tertiary-care Chicago-area medical centers, 2008–2015, was conducted. Case group 1 children possessed KPC-CRE infections; case group 2 harbored carbapenem-susceptible Enterobacteriaceae (CSE) infections; controls had negative cultures. Case-control matching was 1:1:3 by age, infection site and hospital. Statistical and molecular analyses were performed.

Results:
Eighteen KPC-CRE infections were identified; median patient age was 16.5 years. Of 4 available KPC-CRE, 2 were unrelated, non-ST258 KP strains harboring bla
KPC-2, one was a ST258 KP harboring bla
KPC-3, and the last was an E. coli containing bla
KPC-2. KPC-CRE and CSE-infected patients had more multidrug-resistant organisms infections, long-term care facility admissions and lengths of stay (LOS) > 7 days before culture. KPC-CRE and CSE patients had more gastrointestinal comorbidities (odds ratios [Ors], 28.0 and 6.4) and ≥ 3 comorbidities (Or 15.4 and 3.5) compared with controls; KPC-CRE patients had significantly more pulmonary and neurologic comorbidities (both ORs 4.4) or GI and pulmonary devices (ORs, 11.4 and 6.1). Compared with controls, CSE patients had more prior fluoroquinolone use (OR, 7.4); KPC-CRE patients had more carbapenem or aminoglycoside use (ORs, 10.0 and 8.0). Race, gender, LOS and mortality differences were insignificant.

Conclusions:
Pediatric patients with KPC-CRE infection suffer from high multi-system disease/device burdens and exposures to carbapenems and aminoglycosides. Different from adult reports, non-ST258 KP strains were more common, and LOS and mortality rates were similar in all groups. Pediatric CRE control in should focus on modifiable risk factors including antibiotic and device utilization.
Nationwide Study on the Course of Influenza A (H1N1) Infections in Hospitalized Children in the Netherlands During the Pandemic 2009–2010
Authors: Ahout Inge M. L. , Philipsen Ria L. A. , Las Mariëtte , Baysan Meryem , Brus Frank , Rahamat-Langendoen Jeanette C. , Roeleveld Nel , Fraaij Pieter L. , Osterhaus Albert D. M. E. , Ferwerda Gerben , de Groot Ronald 
Published: August 2018

Background:
The influenza H1N1 pandemic of 2009–2010, provided a unique opportunity to assess the course of disease, as well as the analysis of risk factors for severe disease in hospitalized children (< 18 years).

Methods:
Retrospective national chart study on hospitalized children with H1N1 infection during the 2009–2010 pH1N1 outbreak.

Results:
Nine hundred forty patients (56% boys), median age 3.0 years, were enrolled; the majority were previously healthy. Treatment consisted of supplemental oxygen (24%), mechanical ventilation (5%) and antiviral therapy (63%). Fifteen patients died (1.6%), 5 of whom were previously healthy. Multivariable analyses confirmed pre-existent heart and lung disease as risk factors for intensive care unit admission. Risk factors for mortality included children with a neurologic or oncologic disease and psychomotor retardation.

Conclusions:
This nationwide overview of hospitalized children confirms known risk groups for severe influenza infections. However, most of the acute and severe presentations of influenza occurred in previously healthy children.
Pharmacological rescue of nociceptive hypersensitivity and oxytocin analgesia impairment in a rat model of neonatal maternal separation
Authors: Melchior Meggane , Juif Pierre-Eric , Gazzo Géraldine , Petit-Demoulière Nathalie , Chavant Virginie , Lacaud Adrien , Goumon Yannick , Charlet Alexandre , Lelièvre Vincent , Poisbeau Pierrick 
Published: August 2018

AbstractOxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested for being a critical determinant in neurodevelopmental disorders. This hypothalamic neuropeptide exerts a potent analgesic effect through an action on the nociceptive system. This endogenous control of pain has an important adaptive value but might be altered by early life stress, possibly contributing to its long-term consequences on pain responses and associated comorbidities. We tested this hypothesis using a rat model of neonatal maternal separation (NMS) known to induce long-term consequences on several brain functions including chronic stress, anxiety, altered social behavior, and visceral hypersensitivity. We found that adult rats with a history of NMS were hypersensitive to noxious mechanical/thermal hot stimuli and to inflammatory pain. We failed to observe OT receptor–mediated stress-induced analgesia and OT antihyperalgesia after carrageenan inflammation. These alterations were partially rescued if NMS pups were treated by intraperitoneal daily injection during NMS with OT or its downstream second messenger allopregnanolone. The involvement of epigenetic changes in these alterations was confirmed since neonatal treatment with the histone deacetylase inhibitor SAHA, not only normalized nociceptive sensitivities but also restored OT receptor–mediated stress-induced analgesia and the endogenous antihyperalgesia in inflamed NMS rats. There is growing evidence in the literature that early life stress might impair the nociceptive system ontogeny and function. This study suggests that these alterations might be restored while stimulating OT receptor signaling or histone deacetylase inhibitors, using molecules that are currently available or part of clinical trials for other pathologies.
A Novel Method for Assessing Prosthesis Use and Accommodation Practices of People with Transtibial Amputation
Authors: Sanders Joan E. , Redd Christian B. , Larsen Brian G. , Vamos Andrew C. , Brzostowski Jacob T. , Hafner Brian J. , Allyn Katheryn J. , Henrikson Katrina M. , McLean Jake B. , Hinrichs Paul 
Published: August 2018

ABSTRACTIntroductionPractitioners typically rely on patient self-report for information about prosthesis use and limb volume accommodation. Electronic monitoring may provide a more accurate and easier means of collecting these data.MethodsA novel low-profile sensor was used for 2 weeks to track when the limb was within the socket. Each participant also recorded daily prosthesis don times, doff times, and sock changes in a written log.ResultsParticipants (n = 21) wore their prosthesis frequently, for approximately 14.1 hrs/day (interquartile range [IQR], 12.5–14.9), and doffed their prosthesis for 0.5 hr/day (IQR, 0.1–1.2). Of those participants who performed sock changes, participants most often performed sock changes 0.4 times per day (IQR, 0.3–1.0) and socket releases (temporary doffs) 1.3 times per day (IQR, 0.5–3.8). Measured and self-reported beginning-of-prosthesis day were not significantly different (P= 0.002), whereas end-of-prosthesis day were significantly different (P= 0.573).ConclusionsThe developed electronic monitor may improve recording of prosthesis use and monitoring of socket releases. Data collected in this study may serve as a starting point for characterizing socket wear and accommodation in people with limb loss.
Vaginal Intraepithelial Neoplasia: Clinical Presentation, Management, and Outcomes in Relation to HIV Infection Status
Authors: Bradbury Melissa , Xercavins Natalia , García-Jiménez Ángel , Pérez-Benavente Asunción , Franco-Camps Silvia , Cabrera Silvia , Sánchez-Iglesias José Luis , De La Torre Javier , Díaz-Feijoo Berta , Gil-Moreno Antonio , Centeno-Mediavilla Cristina 
Published: August 2018

Objectives
The data available on vaginal intraepithelial neoplasia (VAIN) and infection by HIV are scarce. We therefore aimed to review the clinical presentation, management, and survival outcomes of VAIN in this group of women.

Materials and Methods
This is an observational cohort study of women diagnosed with VAIN for a 23-year period. Clinical characteristics and outcomes were analyzed according to women's HIV infection status. Disease-free and progression-free survival were compared between groups.

Results
Twenty-two of 87 women were HIV positive (25.3%) compared with the HIV-negative group, HIV-positive women were younger (median age = 39 vs 57 years, p < .001) and more frequently smokers (p < .001). They also presented with multifocal and multicentric disease more often (p = .004 and p = .033, respectively) in relation to infection by human papillomavirus. All HIV-positive women were receiving antiretroviral treatment. The median time from the diagnosis of HIV to the development of VAIN was 14 years (range = 1–22 years). There were no significant differences in survival outcomes between groups.

Conclusions
HIV-positive women are at an increased risk of developing VAIN and frequently present at a younger age with multifocal and multicentric disease. Vaginal intraepithelial neoplasia lesions can develop many years after the initial diagnosis of HIV infection reason why prolonged surveillance is essential to enable prompt diagnosis and treatment.
Epidemiology of patients presenting with dyspnea to emergency departments in Europe and the Asia-Pacific region
Authors: Laribi Said , Keijzers Gerben , van Meer Oene , Klim Sharon , Motiejunaite Justina , Kuan Win Sen , Body Richard , Jones Peter , Karamercan Mehmet , Craig Simon , Harjola Veli-Pekka , Holdgate Anna , Golea Adela , Graham Colin , Verschuren Franck , Capsec Jean , Christ Michael , Grammatico-Guillon Leslie , Barletta Cinzia , Garcia-Castrillo Luis , Kelly Anne-Maree 
Published: August 2018

Objective
The primary objective of this study was to describe the epidemiology and management of dyspneic patients presenting to emergency departments (EDs) in an international patient population. Our secondary objective was to compare the EURODEM and AANZDEM patient populations.

Patients and methods
An observational prospective cohort study was carried out in Europe and the Asia-Pacific region. The study included consecutive patients presenting to EDs with dyspnea as the main complaint. Data were collected on demographics, comorbidities, chronic treatment, clinical signs and investigations, treatment in the ED, diagnosis, and disposition from ED.

Results
A total of 5569 patients were included in the study. The most common ED diagnoses were lower respiratory tract infection (LRTI) (24.9%), heart failure (HF) (17.3%), chronic obstructive pulmonary disease (COPD) exacerbation (15.8%), and asthma (10.5%) in the overall population. There were more LRTI, HF, and COPD exacerbations in the EURODEM population, whereas asthma was more frequent in the AANZDEM population. ICU admission rates were 5.5%. ED mortality was 0.6%. The overall in-hospital mortality was 5.0%. In-hospital mortality rates were 8.7% for LRTI, 7.6% for HF, and 5.6% for COPD patients.

Conclusion
Dyspnea as a symptom in the ED has high ward and ICU admission rates. A variety of causes of dyspnea were observed in this study, with chronic diseases accounting for a major proportion.