bluuebunny/crossref_metadata_2025_split huggingface dataset:
A narrative review of the current available literature on the intersection between the climate crisis and paediatric surgical care
Authors: Patel Kavita , Ossig Anna , Kudsk-Iversen Søren 
Published: November 2024

AbstractThe climate crisis exacerbates health inequities, including in paediatric surgery, creating a vicious cycle. We sought to review (a) existing evidence on the connection between paediatric surgery and climate and (b) how this addresses the vicious cycle. A PubMed search was conducted on 23-08-2023. Articles not commenting on "climate change" and "paediatric surgery" were excluded. Included papers were categorised into emerging themes. Out of 151 search results, seven articles were included. The emerging themes related to "Effect of climate on paediatric surgical illness" (n = 3), "Effect of surgery on climate" (n = 2), and "Mitigating impact of paediatric surgery" (n = 2). Five articles were observational studies, and two were literature reviews, all papers published after 2020. We found limited primary research focusing on the intersection between climate change and paediatric surgery. Articles tend to focus on quantifying impact and mitigation, which does not lend itself to climate justice. The syndemic model of health focuses on the complex interconnections and pathways through which health conditions interact within populations to exacerbate adverse health outcomes. We suggest future research needs to be reframed, with the interconnection between health inequities, the climate crisis, and the wider health system addressed together.
Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors
Authors: Jotanovic Jelena , Boldt Henning Bünsow , Burton Mark , Andersen Marianne Skovsager , Bengtsson Daniel , Bontell Thomas Olsson , Ekman Bertil , Engström Britt Edén , Feldt-Rasmussen Ulla , Heck Ansgar , Jakovcevic Antonia , Jørgensen Jens Otto L. , Kraljevic Ivana , Kunicki Jacek , Lindsay John R. , Losa Marco , Loughrey Paul Benjamin , Maiter Dominique , Maksymowicz Maria , Manojlovic-Gacic Emilija , Pahnke Jens , Petersenn Stephan , Petersson Maria , Popovic Vera , Ragnarsson Oskar , Rasmussen Åse Krogh , Reisz Zita , Saeger Wolfgang , Schalin-Jäntti Camilla , Scheie David , Terreni Maria Rosa , Tynninen Olli , Whitelaw Ben , Burman Pia , Casar-Borota Olivera 
Published: November 2024

AbstractAggressive pituitary neuroendocrine tumors (PitNETs)/adenomas are characterized by progressive growth despite surgery and all standard medical therapies and radiotherapy. A subset will metastasize to the brain and/or distant locations and are termed metastatic PitNETs (pituitary carcinomas). Studies of potential prognostic markers have been limited due to the rarity of these tumors. A few recurrent somatic mutations have been identified, and epigenetic alterations and chromosomal rearrangements have not been explored in larger cohorts of aggressive and metastatic PitNETs. In this study, we performed genome-wide methylation analysis, including copy-number variation (CNV) calculations, on tumor tissue specimens from a large international cohort of 64 patients with aggressive (48) and metastatic (16) pituitary tumors. Twelve patients with non-invasive pituitary tumors (Knosp 0–2) exhibiting an indolent course over a 5 year follow-up served as controls. In an unsupervised hierarchical cluster analysis, aggressive/metastatic PitNETs clustered separately from benign pituitary tumors, and, when only specimens from the first surgery were analyzed, three separate clusters were identified: aggressive, metastatic, and benign PitNETs. Numerous CNV events affecting chromosomal arms and whole chromosomes were frequent in aggressive and metastatic, whereas benign tumors had normal chromosomal copy numbers with only few alterations. Genome-wide methylation analysis revealed different CNV profiles and a clear separation between aggressive/metastatic and benign pituitary tumors, potentially providing biomarkers for identification of these tumors with a worse prognosis at the time of first surgery. The data may refine follow-up routines and contribute to the timely introduction of adjuvant therapy in patients harboring, or at risk of developing, aggressive or metastatic pituitary tumors.
Immunoexpression of placental growth factor (PlGF) and soluble FMS-like tyrosine kinase 1 (sFlt-1) in the placental bed of preeclamptic women of African ancestry living with HIV infection
Authors: Mlambo Zinhle P. , Sebitloane Motshedisi , Naicker Thajasvarie 
Published: November 2024

AbstractPreeclampsia, a severe pregnancy complication linked to defective placentation, poses significant maternal risks and is characterized by dysregulated angiogenic factors, including placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1). Women with HIV/AIDS and receiving ART may face an increased susceptibility to preeclampsia development due to immunological and angiogenic imbalance. This study investigates the immunoexpression of these factors in the context of HIV-associated preeclampsia, utilizing morphometric image analysis. The study cohort comprised 180 women, including 60 normotensive and 120 preeclamptic participants, further stratified by HIV status and gestational age (early-onset PE [EOPE] < 34 weeks and late-onset PE [LOPE] ≥ 34 weeks). Placental bed tissues were immunostained with mouse anti-human sFlt-1 and PlGF antibodies, and the results were analyzed using Zeiss Axio-Vision and GraphPad Prism software. sFlt-1 levels showed no significant overall difference between preeclamptic and normotensive women (p = 0.8661), though slightly increased in the preeclamptic myometrium, independent of HIV status. However, sFlt-1 levels were significantly higher in EOPE compared to both normotensive and LOPE groups. PlGF immunostaining also showed no significant overall difference (p = 0.7387) but was notably lower in preeclamptic pregnancies and significantly higher in EOPE compared to LOPE. HIV status did not significantly impact sFlt-1 or PlGF levels, although sFlt-1 was slightly higher in HIV-negative women, while PlGF was marginally higher in HIV-positive women. These findings highlight the complex role of angiogenic factors in preeclampsia pathophysiology and suggest that antiretroviral therapies (ARTs) may contribute to the dysregulation of these factors due to a heightened immune milieu.
Abfallwirtschaft der Zukunft: Designaspekte für Abfalltrennung im öffentlichen Raum
Authors: Rehwald Billie , Kladnik Veronika , Gök Betül , Hartl Barbara , Dworak Sabine , Schwarzböck Therese 
Published: November 2024

Zusammenfassung
Abfälle im öffentlichen Raum rücken zunehmend in den Fokus, da sie nicht nur sichtbar sind, sondern auch wertvolle Ressourcen enthalten, die bisher kaum getrennt gesammelt werden. Gleichzeitig mangelt es an Daten und Forschung, welche die Abfallcharakteristika sowie die vielfältigen Bedürfnisse der beteiligten Akteur:innen (Anbieter:innen, Instandhalter:innen, Konsument:innen) beleuchten. Die vorliegende Studie untersucht, wie ein System zur Abfalltrennung im öffentlichen Raum gestaltet werden kann und welche Einflussfaktoren dabei eine Rolle spielen. Ein interdisziplinäres Forschungsprojekt bildet die Grundlage für einen Katalog von Gestaltungsempfehlungen, der sich in die drei Schwerpunkte Standort und Anordnung, Behälterdesign sowie Information und Kommunikation gliedert. Am Standort sind Faktoren wie Bewegungspfade, Abfalltrennfraktionen sowie die bestehende umliegende Infrastruktur relevant. Beim Behälterdesign spielen Funktionalität und vertraute, klar gekennzeichnete Behälter eine zentrale Rolle, die intuitiv zu bedienen sind. Kommunikation und Information sind entscheidend, um Konsument:innen zur korrekten Abfalltrennung zu motivieren. Eine einfache und verständliche Kennzeichnung der Behälter ist dabei von zentraler Bedeutung. Trotz des geringen Gesamtaufkommens hat der Abfall im öffentlichen Raum aufgrund seines hohen Wertstoffgehalts und Sichtbarkeit eine besondere Bedeutung für das allgemeine Bewusstsein zur Abfalltrennung. Die Studie zeigt jedoch auch Herausforderungen auf, insbesondere die Etablierung der Abfalltrennung als soziale Norm im öffentlichen Raum. Die Ergebnisse der Studie unterstreichen die Notwendigkeit eines interdisziplinären Ansatzes, der Erkenntnisse aus Abfallwirtschaft, Sozialwissenschaften und Design gezielt verknüpft, um nachhaltige Lösungen zu entwickeln und Abfalltrennung im öffentlichen Raum zu fördern.
Plastic waste trade and international agreements
Authors: Ishimura Yuichi , Ichinose Daisuke , Nomura Kai 
Published: November 2024

AbstractThis study investigates the impact of an international environmental agreement that requires prior notification from the country exporting plastic waste and approval from the country importing it. Using bilateral trade data from 2018 to 2022 and the difference-in-differences (DID) approach, we estimate the effect of the Basel Convention Plastic Waste Amendments (BCPWA) on the volume of plastic waste trade from developed to developing countries. We find that the plastic waste trade volume decreases by approximately 63.7% from developed to developing countries following the enforcement of the BCPWA. The findings suggest that an import licensing system and its enforcement could be effective in achieving international environmental agreements, even if it does not ban the import and export of waste. Our study highlights the importance of enforcement mechanisms in international environmental agreements and offers insights for policy design in future global resource management efforts.
Human factors and emerging needs in aerospace manufacturing planning and scheduling
Authors: Morandini Sofia , Fraboni Federico , Hall Mark , Quintana-Amate Santiago , Pietrantoni Luca 
Published: November 2024

AbstractPlanning and Scheduling (P&S) are critical components of organizational management that influence efficiency, overall performance, and human factors in the workplace. The aerospace manufacturing industry is experiencing rapid changes, marked by heightened demands for new aircraft and the need for precise task execution to accommodate increasing air traffic and rigorous safety regulations. This study explores the human factors and emerging needs in the P&S processes within aerospace manufacturing. A qualitative research approach was employed, featuring semi-structured interviews with 15 professionals from a prominent European organization. The participants, actively engaged in P&S operations, were chosen to offer diverse perspectives on their roles and the industry’s specific requirements. Results indicate that planners/schedulers, IT experts, and operations team leaders are crucial in ensuring efficiency throughout the various stages of P&S operations. The findings reveal that emerging needs encompass workforce and customer management (i.e., allocating human resources, responding to client requests, and addressing workforce resistance to new technology adoption), prioritization (i.e., scheduling tasks based on urgency, error susceptibility, and cost efficiency), and contingency handling (i.e., machinery availability, time constraints, quality issues, human performance variability, and weather conditions). These needs highlight the importance of considering human factors and cognitive aspects when designing and implementing P&S systems. The study underscores the challenges the aerospace manufacturing industry faces as it adapts to technological advancements and evolving market conditions. The findings emphasize the necessity of advanced P&S systems that integrate innovative technological solutions with an understanding of human factors and cognition.
Best clinical practice recommendations for the management of symptomatic hemorrhoids via laser hemorrhoidoplasty: the LHP recommendations
Authors:   The LHP Recommendation Development Group, Ambe P. C. , Martin-Martin G. P. , Vasas N. , Piponski I. , Roman I. H. , Hernandez J. D. P. , Ma H. , Lin H.C. , Weyand G. , Mazlan L. , García Flórez L. J. , Wolff K. , Dessily M. , Wang C. , Dobricanin V. , Yang W. , Bruketa T. , Zeng X.D. , Avdicausevic S. , Zhang Z.G. , Wais S. , Kalaskar S. , Cui Z. , Pestonit I. B. , Cao Y.Q. , Suárez Sánchez A. , Ren D.L. , Vargas Castillo E. , Zheng D. , Bogdanic B. , Wölk A. , Yao Y. , Issaad S. , Nasser T. , Guo X.T. , Nagar M. M. , Merkle M. , Ruiz-Lopez M. , Zhang Y. , Blumberg C. , Alam A. A. , Acosta A. C. , Schouten R. , Istok P. , Demtröder C. , Wang Z.Y. , Dong Q. , Wu J. 
Published: November 2024

Abstract
Background
Laser hemorrhoidoplasty (LHP) has emerged as a novel, minimally invasive technique for managing symptomatic hemorrhoids, gaining popularity among clinicians. Despite its increasing adoption, significant variations exist in the application of LHP across different practices.

Purpose
The aim of these recommendations was to spell out some basic principles and recommendations for performing a standard LHP procedure.

Methods
The Recommendation Development Group (RDG) consisting of surgeons with experience in LHP were invited to formulate recommendations for the procedure. The recommendations were generated following systematic literature research and discussion amongst experts (expert opinion) where no substantial literature was available. The developed recommendations were voted upon by a panelist via the Delphi process. Consensus was a priori defined as agreement of 75% and above, with strong consensus defined as 85% and above.

Results
The RDG developed 21 recommendations that were voted upon by 49 panelists. Consensus was reached for all 21 recommendations after the first Delphi round, including 16 recommendations with strong consensus.

Conclusion
The RDP offers a comprehensive suite of guidelines to enhance the safety and efficacy of standard LHP procedures. Out of 21 detailed recommendations, 16 reached strong consensus, collectively addressing the full spectrum of LHP procedures—from laser settings and preoperative preparations to perioperative strategies and postoperative care. This coherent framework is anticipated not only to standardize but also to refine the LHP technique across the board, thereby elevating the management of symptomatic hemorrhoidal disease.
Development of a daily coastal ocean model for Mississippi Sound and Bight
Authors: Cambazoglu Mustafa Kemal , Armstrong Brandy N. , Wiggert Jerry D. 
Published: November 2024

AbstractThe Mississippi Sound and Bight is a complex coastal system with shallow estuarine waters that are highly vulnerable to the effects of climate change and anthropogenic influences. In order to further our understanding of the system and provide natural resource managers and decision-makers with science-based guidance, a pre-operational coastal ocean forecast system has been developed using the Coupled Ocean Atmosphere Wave Sediment Transport Modeling System (COAWST). The COAWST application for Mississippi Bight (msbCOAWST) can be run in hindcast mode, pre-operational near real-time mode, or forecast mode and relies on other operational models including the National Water Model (NWM) for river forcing, the High Resolution Rapid Refresh model (HRRR) for atmospheric forcing, and the Navy Coastal Ocean Model (NCOM) for open ocean boundary forcing. msbCOAWST is being validated using data from a variety of in situ measurements that quantify coastal processes, including tides and water quality parameters (i.e. temperature and salinity). The highest model skill is obtained for temperature followed by water levels and salinity. msbCOAWST has been used to provide guidance for quantifying how freshwater influences derived from river diversion operations impact water quality in estuarine waters. While the model is initially developed to study water quality and circulation in pre-operational near real-time and forecast modes, it is currently being extended to include waves, sediment transport, and biogeochemistry and also linked with habitat suitability models and ecological models in hindcast mode so as to comprehensively reveal consequential environmental concerns due to the onset and persistence of hypoxia, seasonal and storm-induced waves with their associated impacts on the region’s fisheries and shellfisheries.
Exploring the Coping Strategies of Bullying Targets in Organisations Through Abductive Reasoning: An Agent-Based Simulation Approach
Authors: Ho Chia-Hao , Campenni Marco , Manolchev Constantine , Lewis Duncan , Mustafee Navonil 
Published: November 2024

AbstractOver recent decades, workplace bullying and other forms of ‘negative acts’ have become a phenomenon of global interest. Extant scholarship has recognized the negative effects, which escalating acts of verbal and physical aggression can have on individuals and the wider, ethical infrastructure of organisations. While previous studies have explored the antecedents of such negative acts and proposed various intervention and prevention strategies, there remains a critical need to examine the coping strategies employed by those targeted by bullying, particularly in instances where silence is the chosen response. In this pioneering study, we use primary data from two UK National Health Service trusts and agent-based social simulation, to determine whether it is possible to influence the coping strategies of bullying targets. Our findings suggest that perceived organisational support has a strong effect on changing bullying coping strategies, away from external (solicitors, Court of Law) and towards internal channels (colleagues, managers, etc.). We also find that TU membership can moderately influence a change in bullying coping strategies from doing nothing to taking actions. The article makes a conceptual contribution to the literature on coping strategies as a result of (un)ethical behaviour in organisations, offers methodological innovation and makes recommendations to organisational policymakers.
A local, non-commercial tissue bank connected to an organ donor program can produce musculoskeletal allografts of uniform quality at very low costs – ten years’ experience
Authors: Azkia Helia , Harritshøj Lene H. , Nielsen Connie , Agerlin Niels , Jensen Mette G. , Hillingsø Jens G. , Andersen Pia C. , Krogsgaard Michael R. 
Published: November 2024

Abstract
It is common practice that allograft tissues for knee multiligament reconstruction, meniscus transplantation, cartilage replacement and other advanced procedures are made available through commercial banks. The aim was to present the 10-year experience with a local, non-commercial tissue bank, established in 2014. The allograft bank was connected to an existing organ donor program. Following organ procurement, the musculoskeletal tissue is removed and stored immediately, fresh frozen to − 80 degrees Celsius (except hyaline cartilage, which is stored at 5 degrees Celsius). The donor is tested for contagious disease and the grafts for bacteria. When all results are negative, the grafts are released. When thawed before use a swap is cultured. Consecutive, prospectively collected data were analyzed. There were 31 donations, resulting in 1160 grafts. Only 40 grafts (3.4%) had a positive bacteria culture and were discarded. 552 recipients have been treated by use of these allografts. All grafts had negative bacterial cultures in swaps obtained before thawing, and there were no recorded transplantation related complications. The expenses for local grafts were 10–15% of the costs for grafts obtained from foreign banks. Through the local donation program, it was possible to establish a tissue bank with controlled quality grafts at minimal costs, minimizing the need for transportation of frozen grafts retrieved in other countries. Centers for specialized orthopedic surgery using allograft tissue can be self-providing and reduce costs by retrieving and handling allograft tissues locally.
Development of tailored polysaccharide gels through selective Diels–Alder crosslinking
Authors: Atmani Zakaria , Heinze Thomas , Gericke Martin 
Published: November 2024

Abstract
Novel polysaccharide gels were prepared by a covalent crosslinking of xylan and cellulose derivatives through Diels–Alder (DA) cycloaddition. For this purpose, polysaccharide carbamates were synthesized through a modular approach that incorporated either furfuryl or maleimide moieties for DA reaction as well as solubilizing tertiary amino or quaternary ammonium moieties that facilitated water solubility. All compounds were fully characterized with respect to degrees of substitution (DS) and molecular structures. Organogels and hydrogels were prepared by selective covalent crosslinking of the derivatives through DA reaction. The gelation process was monitored by rheological measurements to evaluate the kinetics with respect to different crosslinking conditions and the gels were characterized with respect to mechanical properties as well as drying and reswelling behavior. Moreover, several side reactions that occurred during the gelation were identified and it was possible to adjust the molecular structure accordingly to avoid these issues. Thus, it was possible to obtain novel polysaccharide-based organogels and hydrogels that displayed thermoreversible behavior, as well as good mechanical stability and re-swelling capacities.

Graphical abstract
Investigation of introgressive hybridization in endangered Sinohyriopsis mussels (Mollusca: Unionidae) using genome-wide data in Japan
Authors: Ishii Yasuto , Kawamoto Youdai , Shirai Akihisa , Saito Takumi , Yamazaki Daishi , Ye Bin , Ito Shun , Kondo Takaki , Hirano Takahiro , Chiba Satoshi , Sano Isao 
Published: November 2024

Abstract
Anthropogenic hybridization is a global phenomenon and a major concern in conservation biology. Sinohyriopsis schlegelii (Mollusca: Bivalvia: Unionidae), native to Lake Biwa in Japan, is considered endangered because of its hybridization with an introduced Chinese species, S. cumingii. Although previous research suggested hybridization among Sinohyriopsis mussels, the research has failed to (1) evaluate the prevalence of hybrids, (2) predict the genetic consequences for populations containing hybrids, and (3) genetically assess a population devoid of hybrids. This study aimed to fill the knowledge gaps. We collected samples from all persistent populations in Lake Biwa, Lake Kasumigaura, and Lake Anenuma (the latter two populations were introduced from Lake Biwa) and analyzed genome-wide single nucleotide polymorphisms (SNPs) data. Our findings demonstrate that hybrids are prevalent in Lake Biwa and Lake Kasumigaura but absent in Lake Anenuma. The proportion of S. cumingii ancestry increased over the past 20 years, indicating that the genetic material of S. schlegelii may diminish further in the future. Moreover, the S. schlegelii population in Lake Anenuma shared genetic similarities with the pre-hybridization population of Lake Biwa. Although the Lake Anenuma population exhibited lower genetic diversity, no signs of inbreeding were observed. Overall, the Lake Anenuma population remains the only genetically pure S. schlegelii population, but its low genetic diversity indicates a reduced adaptive potential to environmental changes. This study provides valuable insights into the current genetic status of S. schlegelii, ultimately informing conservation efforts for this critically endangered species.