bluuebunny/crossref_metadata_2025_split huggingface dataset:
Duodenal-type and nodal follicular lymphomas differ by their immune microenvironment rather than their mutation profiles
Authors: Hellmuth Johannes C. , Louissaint Abner , Szczepanowski Monika , Haebe Sarah , Pastore Alessandro , Alig Stefan , Staiger Annette M. , Hartmann Sylvia , Kridel Robert , Ducar Matthew D. , Koch Peter , Dreyling Martin , Hansmann Martin-Leo , Ott German , Rosenwald Andreas , Gascoyne Randy D. , Weinstock David M. , Hiddemann Wolfgang , Klapper Wolfram , Weigert Oliver 
Published: October 2018

Key Points
The mutational landscape of DTFL is highly related to nodal FL but harbors fewer multiple/biallelic mutations in KMT2D. The immune microenvironment of DTFL is distinct from nodal FL and characterized by a chronic inflammation gene signature.
Defining the minimally clinically important difference of the SF-36 physical function subscale for paediatric CFS/ME: triangulation using three different methods
Authors: Brigden Amberly , Parslow Roxanne M , Gaunt Daisy , Collin Simon M , Jones Andy , Crawley Esther 
Published: October 2018

Abstract
Background
Defining the minimally clinically important difference (MCID) is important for the design and analysis of clinical trials and ensures that findings are clinically meaningful. Studies in adult populations have investigated the MCID of The Short Form 36 physical function sub-scale (SF-36-PFS). However, to our knowledge no studies have defined the MCID of the SF-36-PFS in a paediatric population. We aimed to triangulate findings from distribution, anchor and qualitative methods to identify the MCID of the SF-36-PFS for children and adolescents with CFS/ME.

Methods
Quantitative methods: We analysed routinely-collected data from a specialist paediatric CFS/ME service in South-West England using: 1) the anchor method, based on Clinical Global Impression (CGI) outcomes at 6 months’ follow-up; 2) the distribution method, based on the standard deviation of baseline SF-36-PFS scores.
Qualitative methods: Young people (aged 12–17 years) and parents were asked to complete the SF-36-PFS, marking each question twice: once for where they would currently rate themselves/their child and a second time to show what they felt would be the smallest amount of change for them/their child to feel treatment had made a difference. Semi-structured interviews were designed to explore what factors were deemed important to patients and to what extent an improvement was considered satisfactory. We thematically analysed qualitative interviews from 21 children and their parents.

Results
Quantitative results: Six-month follow-up data were available for 198 children with a mean age of 14 years. Most were female (74%, 146/198) and 95% gave their ethnicity as “White British”.
Half the standard deviation of the baseline SF-36-PFS scores was 11.0. “A little better” on the CGI equated to a mean difference on the SF-36-PFS from baseline to 6-month follow-up of 9.0.
Qualitative results: Twenty-one children with CFS/ME participated: 16 females (76.2%) with a mean age of 14.4 years. Twenty mothers and two fathers were also interviewed.
The median minimal improvement in the SF-36-PFS was 10. Participants indicated that small changes in physical function can lead to important improvements in valued social and family function. Patients and parents were positive about improvement even in the presence of persisting symptoms.
Triangulation: The MCID based on the mean score from the three methods was 10.

Conclusions
Converging evidence indicates future studies in paediatric CFS/ME should use an MCID of 10 on the SF-36-PFS.
Collaborative organizational forms: on communities, crowds, and new hybrids
Authors: Kolbjørnsrud Vegard 
Published: October 2018

AbstractIn this article, I examine collaborative organizational forms in terms of their institutional properties and the mechanisms by which they solve the universal problems of organizing. Based on three ideal forms—markets, hierarchies, and communities—I propose a framework for analyzing and mapping organizational forms. The framework expands our understanding of the ideal forms and derives a set of analytically distinct hybrids at the intersection of the ideal types. The framework also specifies the main conditions that drive organizations to change form and move toward another hybrid or ideal form. The theoretical review of collaborative organizational forms is illustrated and informed by three empirical cases of new forms within the domains of drug discovery, software development, as well as professional services. Further, I discuss plural forms and the role of hierarchy in collaborative forms. Finally, I outline implications for research and practice in terms of comparative analysis of organizational forms, the role of crowds, as well as the interplay between new technologies and new organizational forms.
Trial Reporting in Immuno-Oncology (TRIO): An American Society of Clinical Oncology-Society for Immunotherapy of Cancer Statement
Authors: Tsimberidou Apostolia M. , Levit Laura A. , Schilsky Richard L. , Averbuch Steven D. , Chen Daniel , Kirkwood John M. , McShane Lisa M. , Sharon Elad , Mileham Kathryn F. , Postow Michael A. 
Published: October 2018

Purpose To develop recommendations for clinical trial reporting that address the unique efficacy, toxicity, and combination and sequencing aspects of immuno-oncology (IO) treatments. Methods ASCO and the Society for Immunotherapy of Cancer (SITC) convened a working group that consisted of practicing medical oncologists, immunologists, clinical researchers, biostatisticians, and representatives from industry and government to develop Trial Reporting in Immuno-Oncology (TRIO) recommendations. These recommendations are based on expert consensus, given that existing data to support evidence-based recommendations are limited. Conclusion The TRIO recommendations are intended to improve the reporting of IO clinical trials and thus provide more complete evidence on the relative benefits and risks of an IO therapeutic approach. Given the rapid expansion of the number of IO clinical trials and ongoing improvements to the evidence base supporting the use of IO treatments in clinical care, these recommendations will likely need regular revision as the IO field develops.
Exploitation of Precision Medicine Trials Data: Examples of Long Responders From the SHIVA01 Trial
Authors: Basse Clémence , Morel Claire , Callens Céline , Pierron Gaëlle , Servois Vincent , Vincent-Salomon Anne , Jobard Aude , Alt Marie , Ricci Francesco , Loirat Delphine , Sablin Marie-Paule , Bretagne Marie , Saint-Ghislain Mathilde , Hescot Ségolène , Gonçalves Anthony , Tredan Olivier , Dubot Coraline , Gavoille Céline , Delord Jean-Pierre , Campone Mario , Isambert Nicolas , Belin Lisa , Bieche Ivan , Kamal Maud , Le Tourneau Christophe 
Published: October 2018

Purpose Precision medicine trials constitute a precious source of molecular data with prospective clinical annotations allowing the exploration of patients’ subpopulations according to specific clinical or biological questions. Using the SHIVA01—the first randomized trial comparing molecularly targeted therapy on the basis of tumor molecular profiling versus conventional chemotherapy in metastatic cancer patients who failed standard of care therapy—annotated database, we report cases of patients treated in the trial with targeted therapy who experienced an objective response or prolonged disease stabilization in light of patients’ molecular alterations. Patients and Methods We selected all patients included in SHIVA01 treated with a molecularly targeted agent (MTA) who experienced an objective response or disease stabilization that lasted longer than 6 months according to Response Evaluation Criteria in Solid Tumors version 1.1. Results Among the 170 patients who received MTAs in the SHIVA01 trial, 15 patients (9%) experienced an objective response (n = 3) or disease stabilization that lasted longer than 6 months (n = 12). The most frequent histologic subtypes were breast cancer (27%) and cervical cancer (20%). Six patients, including three patients with breast cancer, were treated with abiraterone on the basis of androgen receptor protein overexpression. Five patients were treated with everolimus on the basis of a PTEN heterozygous deletion with loss of protein expression, PIK3CA mutation, or both alterations. The remaining four patients were treated with tamoxifen, erlotinib, imatinib, and vemurafenib on the basis of progesterone receptor expression, EGFR amplification, KIT mutation, and BRAF mutation, respectively. TP53 mutations were absent in responder patients. Conclusion Analysis of patients who experienced objective responses or disease stabilization that lasted longer than 6 months allowed the identification of potential biomarkers of sensitivity and resistance to MTAs.
Clinical Utility of Gene Expression Classifiers in Men With Newly Diagnosed Prostate Cancer
Authors: Hu Jonathan C. , Tosoian Jeffrey J. , Qi Ji , Kaye Deborah , Johnson Anna , Linsell Susan , Montie James E. , Ghani Khurshid R. , Miller David C. , Wojno Kirk , Burks Frank N. , Spratt Daniel E. , Morgan Todd M. 
Published: October 2018

Purpose Tissue-based gene expression classifiers (GECs) may assist with management decisions in patients with newly diagnosed prostate cancer. We sought to assess the current use of GEC tests and determine how the test results are associated with primary disease management. Methods In this observational study, patients diagnosed with localized prostate cancer were tracked through the Michigan Urological Surgery Improvement Collaborative registry. The utilization and results of three GECs (Decipher Prostate Biopsy, Oncotype DX Prostate, and Prolaris) were prospectively collected. Practice patterns, predictors of GEC use, and effect of GEC results on disease management were investigated. Results Of 3,966 newly diagnosed patients, 747 (18.8%) underwent GEC testing. The rate of GEC use in individual practices ranged from 0% to 93%, and patients undergoing GEC testing were more likely to have a lower prostate-specific antigen level, lower Gleason score, lower clinical T stage, and fewer positive cores (all P < .05). Among patients with clinical favorable risk of cancer, the rate of active surveillance (AS) differed significantly among patients with a GEC result above the threshold (46.2%), those with a GEC result below the threshold (75.9%), and those who did not undergo GEC (57.9%; P < .001 for comparison of the three groups). This results in an estimate that, for every nine men with favorable risk of cancer who undergo GEC testing, one additional patient may have their disease initially managed with AS. On multivariable analysis, patients with favorable-risk prostate cancer who were classified as GEC low risk were more likely to be managed on AS than those without testing (odds ratio, 1.84; P = .006). Conclusion There is large variability in practice-level use and GEC tests ordered in patients with newly diagnosed, localized prostate cancer. In patients with clinical favorable risk of cancer, GEC testing significantly increased the use of AS. Additional follow-up will help determine whether incorporation of GEC testing into initial patient care favorably affects clinical outcomes.
Specimens of Convolvulaceae linked to the plates of Dillenius’s Hortus Elthamensis
Authors: Wood John R.I. , Marner Serena K. , Scotland Robert W. , Harris Stephen A. 
Published: October 2018

AbstractDillenius’s Hortus Elthamensis was published in 1732. In most versions the plates are uncoloured, but a few surviving coloured versions are known. The plates are of considerable historical and scientific importance as many Linnaean types are founded on these illustrations. The specimens on which the plates were based are still housed in the Oxford University Herbaria (OXF) and examples from Convolvulaceae are discussed to show how the plates were based on and sometimes copied exactly from the original specimens. A second‐step lectotypification is made for Ipomoea glaucifolia. Our study of Convolvulaceae types highlights the value of consulting corresponding specimens in other families when interpreting ambiguous types based on plates in Hortus Elthamensis.
A nomenclatural revision of Littorella (Plantaginaceae: Plantagineae)
Authors: Hassemer Gustavo , Moroni Pablo , O’Leary Nataly 
Published: October 2018

AbstractLittorella is a small genus of three herbaceous aquatic species distributed in Europe, northeastern North America and southern South America. Here we provide a complete nomenclatural revision for this genus, where lectotypes are designated for the names of its three accepted species, including the Linnaean name Plantago uniflora, which is the basionym of L. uniflora.
Outcomes of Combined Treatment for Breast Cancer with Immediate Implant-Based Breast Reconstruction, Chemotherapy and Conformal Radiotherapy
Authors: Тимошкина Е. , Timoshkina E. , Ткачев Сергей , Tkachev Sergey , Назаренко А. , Nazarenko A. , Трофимова Оксана , Trofimova Oksana , Глебовская В. , Glebovskaya V. , Иванов С. , Ivanov S. , Бори­сова Т. , Borisova T. 
Published: October 2018

Purpose: To evaluate the oncological results and late complication rate in breast cancer patients who underwent immediate implant-based breast reconstruction and adjuvant radiotherapy. Material and methods: 32 patients with I–IIIC breast cancer after combined treatment which included immediate implant-based breast reconstruction, chemotherapy and radiotherapy, were reviewed. Results: All 32 patients got skin erythema as an acute adverse effect. 6 (18 %) of them got acute mucositis. Median follow-up was 35 months (range 12–112 months). 2 (6 %) patients had local recurrence after 46 and 31 months since the operation day. Locoregional control rate was 94 %. 9 (28 %) patients presented distant metastases at term 8–71 months since the operation day, and metastases in bones, brain, lungs, liver and non-regional lymph nodes were diagnosed. 2 (6 %) patients died because of disease progression. Late adverse effects of skin and soft tissue in irradiated area were found in 4 (13 %) patients – capsular contracture was diagnosed 1 (n = 1), 2 (n = 2) and 3 (n = 1) stages. In two cases of four, capsular contracture was asymptomatic and found during the second stage of breast reconstruction while changing tissue expander to implant. Capsulotomy was performed, and aesthetic effect was good. In one case capsular contracture was the reason of implant removal, and then second reconstruction using tissue expander was performed. Conclusion: Nowadays immediate implant-based breast reconstruction is an essential part of combined treatment. Breast cancer patients after immediate implant-based breast reconstruction can be treated in adequate manner, and breast reconstruction is not a contraindication for radiotherapy. Low complication rates can still be acquired with the use of state-of-art 3D and 4D radiotherapy techniques and supportive care.
SPECT/CT in the Assessment of the Jaw Autograft Viability
Authors: Рыжков А. , Ryzhkov A. , Яковлева Л. , Yakovleva L. , Крылов А. , Krylov A. , Ширяев С. , Shiryaev S. , Кропотов М. , Kropotov M. , Соболевский В. , Sobolevsky V. , Диков Ю. , Dikov Yu. , Азимова Р. , Azimova1 R. , Ивашков В. , Ivashkov V. 
Published: October 2018

Purpose: To evaluate the effectiveness of SPECT/CT for the assessment of graft viability following revascularized bone grafts in patients with mandibular (18) and maxilla (1) reconstruction.
Material and methods: We investigated 19 patients with revascularized grafts from the fibula (16 patients), iliac crest (2 patients) and shoulder blade graft (1). For the follow up of all these patients, 99mTc-MDP bone scintigraphy and SPECT/CT was performed between 4–5 days postoperatively. The evaluation of the grafts was based on a comparison of tracer uptake between graft and the cranium.
Results: 17 of 19 grafts had an uncomplicated clinical course. Complications in the graft occurred in two patients. In the analysis of planar scintigrams with uncomplicated healing were showed correct assessment in 10 of 17 patients and in 1of 2 patients with signs of necrosis of graft fragments. SPECT/CT was performed in addition to planar imaging.
The increased uptake grafts were showed with SPECT/CT in all patients with uncomplicated clinical course. In the failed 2 grafts, decreased uptake was observed in both patients. In the analysis of SPECT/CT images the correct results were showed in all clinical cases.
Conclusion: SPECT/CT performed within 6 days after the mandibular reconstruction is a useful tool to monitor the viability and early complications of revascularized mandibular and maxilla bone grafts. SPECT/CT is also recommended to interpretation of the bone scans and to precise assessment of graft viability.
Cattle’s Thyroid Dose Estimation with Compartmental Model of Iodine Metabolism and Monte Carlo Transport Technique
Authors: Кураченко Ю. , Kurachenko Yu. , Санжарова Н. , Sanzharova N. , Козьмин Г. , Kozmin G. , Бударков В. , Budarkov V. , Денисова Э. , Denisova E. , Снегирев А. , Snegirev A. 
Published: October 2018

Purpose: This work aims first to improve the reliability of absorbed dose calculation in critical organs of cattle during internal irradiation immediately after radiation accidents by a) improving the compartmental model of radionuclide metabolism in animal body; b) the use of precision computing technologies for modeling as the domain, and the actual radiation transport. In addition, the aim of the work is to determine the agreed values of the 131I critical dose in the cattle thyroid, leading to serious gland dysfunction and its follow-up destruction.
Material and methods: To achieve aforecited goals, comprehensive studies were carried out to specify the parameters of the compartmental model, based on reliable experimental and theoretical data. Voxel technologies were applied for modeling the subject domain (thyroid gland and its environment). Finally, to solve the 131I radiation transport equation, the Monte Carlo code was applied, which takes into account the contribution of gamma and beta radiation source, and the contribution of the entire chain of secondary radiations in the dose calculation, up to the total energy dissipation.
Results: As the main theoretical result, it is necessary to emphasize the conversion factor from the 131I activity, distributed uniformly in volume of the thyroid gland, to the average dose rate in the gland (Bq × Gy/s). This factor was calculated for both cows and calves in the selected domain configuration and thyroid morphology. The main practical result is a reliable estimation the lower bound of the absorbed dose in the thyroid, which in a short time leads to its destruction under internal 131I irradiation: ~300 Gy.
Conclusion: Usage a compartmental model of the 131I metabolism with biokinetic parameters, received on the basis of reliable experimental data, and precise models of both the subject area and radiation transport for evaluation the dose in the cattle thyroid after the radiation accident allowed to obtain reliable values of the thyroid dose, adducting to its destruction at short notice.
FABP3 in the Anterior Cingulate Cortex Modulates the Methylation Status of the Glutamic Acid Decarboxylase67Promoter Region
Authors: Yamamoto Yui , Kida Hiroyuki , Kagawa Yoshiteru , Yasumoto Yuki , Miyazaki Hirofumi , Islam Ariful , Ogata Masaki , Yanagawa Yuchio , Mitsushima Dai , Fukunaga Kohji , Owada Yuji 
Published: October 2018

Polyunsaturated fatty acids (PUFAs) are essential for brain development and function. Increasing evidence has shown that an imbalance of PUFAs is associated with various human psychiatric disorders, including autism and schizophrenia. Fatty acid-binding proteins (FABPs), cellular chaperones of PUFAs, are involved in PUFA intracellular trafficking, signal transduction, and gene transcription. In this study, we show that FABP3 is strongly expressed in the GABAergic inhibitory interneurons of the male mouse anterior cingulate cortex (ACC), which is a component of the limbic cortex and is important for the coordination of cognitive and emotional behaviors. Interestingly,Fabp3KO male mice show an increase in the expression of the gene encoding the GABA-synthesizing enzyme glutamic acid decarboxylase 67 (Gad67) in the ACC. In the ACC ofFabp3KO mice,Gad67promoter methylation and the binding of methyl-CpG binding protein 2 (MeCP2) and histone deacetylase 1 (HDAC1) to theGad67promoter are significantly decreased compared with those in WT mice. The abnormal cognitive and emotional behaviors ofFabp3KO mice are restored by methionine administration. Notably, methionine administration normalizesGad67promoter methylation and its mRNA expression in the ACC ofFabp3KO mice. These findings demonstrate that FABP3 is involved in the control of DNA methylation of theGad67promoter and activation of GABAergic neurons in the ACC, thus suggesting the importance of PUFA homeostasis in the ACC for cognitive and emotional behaviors.SIGNIFICANCE STATEMENTThe ACC is important for emotional and cognitive processing. However, the mechanisms underlying its involvement in the control of behavioral responses are largely unknown. We show the following new observations: (1) FABP3, a PUFA cellular chaperone, is exclusively expressed in GABAergic interneurons in the ACC; (2) an increase inGad67expression is detected in the ACC ofFabp3KO mice; (3) theGad67promoter is hypomethylated and the binding of transcriptional repressor complexes is decreased in the ACC ofFabp3KO mice; and (4) elevatedGad67expression and abnormal behaviors seen inFabp3KO mice are mostly recovered by methionine treatment. These suggest that FABP3 regulates GABA synthesis through transcriptional regulation ofGad67in the ACC.