bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular risk stratification in primary care patients with arterial hypertension: Results from the Swiss Hypertension Cohort Study (HccH)
Authors: Handschin Anja , Brighenti-Zogg Stefanie , Mundwiler Jonas , Giezendanner Stéphanie , Gregoriano Claudia , Martina Benedict , Tschudi Peter , Leuppi Jörg D , Zeller Andreas , Dieterle Thomas 
Published: June 2019

Aims Few data are available on cardiovascular risk stratification in primary care patients treated for arterial hypertension. This study aimed at evaluating the cardiovascular risk profile of hypertensive patients included into the Swiss Hypertension Cohort Study according to the 2013 European Society of Hypertension/European Society of Cardiology Guidelines. Methods The Swiss Hypertension Cohort Study is a prospective, observational study conducted by the Centre for Primary Health Care of the University of Basel from 2006 to 2013. Patients with a diagnosis of arterial hypertension (office blood pressure measurement ≥140/90 mmHg) were enrolled. Office blood pressure measurement, cardiovascular risk factors, subclinical organ damage, diabetes mellitus, and established cardiovascular and renal disease were recorded at baseline and at an annual interval during routine consultations by general practitioners in Switzerland. Results In total, 1003 patients were eligible for analysis (55.6% male, mean age: 64.0 ± 13.2 years). At baseline, 78.5% of patients presented with either more than three additional cardiovascular risk factors, diabetes mellitus or subclinical organ damage, while 44.4% of patients had a high or very high overall cardiovascular risk. Cardiovascular risk factors and information about diabetes mellitus, established cardiovascular disease and renal disease were recorded mostly completely, whereas substantial gaps were revealed regarding the assessment of subclinical organ damage. Conclusion The present findings demonstrate that the majority of primary care patients with arterial hypertension bear a substantial number of additional cardiovascular risk factors, subclinical and/or established organ damage. This emphasizes the need for continuous cardiovascular risk stratification and adequate treatment of arterial hypertension in Switzerland.
A unified multidisciplinary fragility hip fracture pilot pathway in a trauma centre in Hong Kong: One-year outcome in the acute phase
Authors: Lee Matthew WH , Chui KH , Tsang KK , Lee KB , Li Wilson 
Published: June 2019

Introduction: The growing impact of fragility hip fracture (FHF) on the healthcare system and the society has become a major concern worldwide. A unified multidisciplinary FHF pathway from admission to rehabilitation and back to community was established in 2015. The acute phase of the pathway was put into pilot in our hospital to evaluate the outcome. Method: A designated FHF team was established in our centre since January 2015. The FHF pathway was piloted since June 2015. Patients admitted with a hip fracture resulting from fall on standing height were included. Major outcome parameters were compared in three phases: (1) before FHF team and FHF pathway (January to December 2014), (2) after FHF team but before FHF pathway (January to May 2015) and (3) after FHF team and FHF pathway (June 2015 to May 2016). Result: In phases 1, 2 and 3, 631, 263 and 634 patients were included, respectively. From phases 1 to 3, the average key performance indicator (KPI) has improved from 49.2% to 65.8% to 70.0% significantly; average acute length of stay (days) has improved from 13.7 to 13.4 to 11.3 significantly; total surgical complication rates have improved from 6.2% to 7.6% to 5.8%. The 30-day mortality rate and the unplanned readmission rate (within 28 days) have remained below 2.7% and 2.2%, respectively. Conclusions: Implementation of an FHF pathway can form a multidisciplinary platform that can improve the standard of care and outcome for our FHF patients in terms of KPI and also length of stay. New knowledge added by this study: A newly designed and implemented fragility hip fracture pathway in our centre as a pilot with the results evaluated. Implications for clinical practice or policy: With the increasing elderly population in Hong Kong and globally, there is a need to design and implement a fragility hip fracture (FHF) pathway to improve the care and effectiveness for FHF patients.
Three-point atlantoaxial fixation with C1–C2 transarticular screws and C1 lateral mass screws
Authors: Harati Ali , Oni Paul 
Published: June 2019

Background: Based on established posterior atlantoaxial fixation techniques, we present a novel technique that uses a polyaxial screw rod system and utilizes a combination of C1 lateral mass and C1–C2 transarticular screws. Methods: We conducted a retrospective review of six men and four women (mean age: 57, range: 20–86). Indication for atlantoaxial fixation was type II odontoid fractures or pseudarthrosis after odontoid fracture ( n = 7), rheumatoid arthritis ( n = 2) and os odontoideum ( n = 1). Results: The mean follow-up time was 48 months (range: 24–72). There were no intraoperative complications such as vertebral artery, nerve root or spinal cord injury. Post-operative imaging showed no screw malposition. During follow-up, no patient had screw loosening, screw fracture or bone absorption around the screws. Clinically, patient neck pain improved in all cases. Conclusions: C1 lateral mass and C1–C2 transarticular polyaxial screw rod fixation is a novel and potentially effective surgical technique for achieving immediate rigid immobilization of the C1–C2 motion segment. However, further biomechanical studies should be performed to prove our clinical results.
PTENP1/miR-20a/PTEN axis contributes to breast cancer progression by regulating PTEN via PI3K/AKT pathway
Authors: Gao Xue , Qin Tao , Mao Jun , Zhang Jun , Fan Shujun , Lu Ying , Sun Zhigang , Zhang Qingqing , Song Bo , Li Lianhong 
Published: June 2019

Abstract
Background
Long non-coding RNA PTENP1, the pseudogene of PTEN tumor suppressor, has been reported to exert its tumor suppressive function via modulation of PTEN expression in many malignancies, including breast cancer (BC). However, whether the PTENP1/miR-20a/PTEN axis exists and how it functions in BC progression remains elusive.

Methods
The levels of PTENP1, PTEN and miR-20a were measured by qRT-PCR. Furthermore, the breast cancer cells proliferation was further measured by CCK8 assay, colony formation assays, EDU and Ki67 staining. The migratory and invasive ability was determined by transwell assay. Flow cytometry, JC-1 and TUNEL assays were conducted to show the occurrence of apoptosis. Xenograft model was used to show the tumorigenesis of breast cancer cells.

Results
We analyzed PTENP1 and PTEN levels in clinical BC samples and cell lines, and found that PTENP1 and PTEN were confirmed and closely correlated with the malignancy of BC cell lines and poor clinical prognosis. Moreover, alteration of PTENP1 affects BC cell proliferation, invasion, tumorigenesis and chemoresistance to adriamycin (ADR). Bioinformatic analysis and dual-luciferase reporter gene assay predicted that PTENP1 was a direct target of miR-20a, which was clarified an alternative effect on BC aggressiveness phenotype. In addition, PTENP1 functioned as an endogenous sponge of miR-20a to regulate PTEN expression, which mediated BC cells proliferation, invasion and drug resistance via activation the phosphatidylinositol-3 kinase (PI3K)/AKT pathway. PI3K inhibitor LY294002 or siAkt also prevented BC cells progression.

Conclusion
Collectively, these data indicated that PTENP1/miR-20a/PTEN axis involved in the malignant behaviors of BC cells, illuminating the possible mechanism mediated by PTEN via PI3K/Akt pathway. Targeting PTENP1/miR-20a/PTEN may provide a potential diagnosis and treatment strategy for BC.
Basic symptoms in offspring of parents with mood and psychotic disorders
Authors: Zwicker Alyson , MacKenzie Lynn E. , Drobinin Vladislav , Howes Vallis Emily , Patterson Victoria C. , Stephens Meg , Cumby Jill , Propper Lukas , Abidi Sabina , Bagnell Alexa , Schultze-Lutter Frauke , Pavlova Barbara , Alda Martin , Uher Rudolf 
Published: June 2019

Background
Basic symptoms, defined as subjectively perceived disturbances in thought, perception and other essential mental processes, have been established as a predictor of psychotic disorders. However, the relationship between basic symptoms and family history of a transdiagnostic range of severe mental illness, including major depressive disorder, bipolar disorder and schizophrenia, has not been examined.

Aims
We sought to test whether non-severe mood disorders and severe mood and psychotic disorders in parents is associated with increased basic symptoms in their biological offspring.

Method
We measured basic symptoms using the Schizophrenia Proneness Instrument – Child and Youth Version in 332 youth aged 8–26 years, including 93 offspring of control parents, 92 offspring of a parent with non-severe mood disorders, and 147 offspring of a parent with severe mood and psychotic disorders. We tested the relationships between parent mental illness and offspring basic symptoms in mixed-effects linear regression models.

Results
Offspring of a parent with severe mood and psychotic disorders (B = 0.69, 95% CI 0.22–1.16, P = 0.004) or illness with psychotic features (B = 0.68, 95% CI 0.09–1.27, P = 0.023) had significantly higher basic symptom scores than control offspring. Offspring of a parent with non-severe mood disorders reported intermediate levels of basic symptoms, that did not significantly differ from control offspring.

Conclusions
Basic symptoms during childhood are a marker of familial risk of psychopathology that is related to severity and is not specific to psychotic illness.

Declaration of interest
None.
Promoting resilience in children and adolescents living with parental mental illness (CAPRI): children are key to identifying solutions
Authors: Abel Kathryn M. , Hope Holly , Faulds Annie , Pierce Matthias 
Published: June 2019

SummaryThe lives of Children and Adolescents with PaRental mental Illness (CAPRI) represent a public health priority. Identifying those at most risk within the risk subset is crucial to promote resilience for this group. The ability to develop child-centred interventions will underpin the success of evidence-based services and CAPRI themselves are key to unlocking current service barriers.Declaration interestNone.
Percutaneous MR-guided prostate cancer cryoablation technical updates and literature review
Authors: de Marini Pierre , Cazzato Roberto Luigi , Garnon Julien , Shaygi Behnam , Koch Guillaume , Auloge Pierre , Tricard Thibault , Lang Hervé , Gangi Afshin 
Published: June 2019

Prostate cancer (PCa) is the most common malignant tumor in males. The benefits in terms of overall reduction in specific mortality due to the widespread use of Prostate Specific Antigen (PSA) screening and the advancements in the curative treatments (radical prostatectomy or radiotherapy) appear to have reached a plateau. There remains, however, the questions of overdiagnosis and overtreatment of such patients. Currently, the main challenge in the treatment of patients with clinically organ-confined PCa is to offer an oncologically efficient treatment with as little morbidity as possible. Amongst the arising novel curative techniques for PCa, cryoablation (CA) is the most established one, which is also included in the NICE and AUA guidelines. CA is commonly performed under ultrasound guidance with the inherent limitations associated with this technique. The recent advancements in MRI have significantly improved the accuracy of detecting and characterizing a clinically significant PCa. This, alongside the development of wide bore interventional MR scanners, has opened the pathway for in bore PCa treatment. Under MRI guidance, PCa CA can be used either as a standard whole gland treatment or as a tumor targeted one. With MR-fluoroscopy, needle guidance capability, multiplanar and real-time visualization of the iceball, MRI eliminates the inherent limitations of ultrasound guidance and can potentially lead to a lower rate of local complications. The aim of this review article is to provide an overview about PCa CA with a more specific insight on MR guided PCa CA; the limitations, challenges and applications of this novel technique will be discussed.
Feasibility of high resolution ultrasound for SLAP tears of the shoulder compared to MR arthrogram
Authors: Alali Akeel , Li David , Monteiro Sandra , Choudur Hema 
Published: June 2019

Objectives: The purpose of this prospective pilot study was to evaluate the feasibility and accuracy of high resolution ultrasound in the detection of superior labral anteroposterior (SLAP) tears of the shoulder compared to MR arthrogram. Methods and materials: 48 adult patients were included in the study. All patients had high resolution ultrasound of the superior labrum and biceps labral anchor prior to MR arthrogram. Ultrasound and MR arthrograms were evaluated separately for the presence or absence of SLAP tear using the same grading. The presence or absence of a tear and grading of the tears on MR arthrograms and ultrasound were compared and evaluated using κ statistics. Results: Both MRI and ultrasound demonstrated a SLAP tear in 27 of the 48 patients. MRI and ultrasound were in agreement on the absence of a tear in 19 patients. There was a disagreement between MRI and ultrasound in 2 of the 48 patients regarding the existence of a tear. The two modalities demonstrated substantial agreement on the presence or absence of a tear ( κ = 91.4 %, p < 0.001) as well as the grading of the tear ( κ = 84.4 %, p < 0.001). Conclusions: In this pilot study, the feasibility and accuracy of high resolution ultrasound for SLAP tears were evaluated and compared with MR arthrogram. MRI and ultrasound demonstrated substantial agreement on the presence or absence of SLAP tears and grading of the tears. Advances in knowledge: This pilot study explores and supports the use of ultrasound as a screening tool for SLAP tears, especially as it is readily available, fast and inexpensive.
Diversity of phenotypic characteristics of White Tailed-Yellow Chicken populations reared under free range system in Phitsanulok Province, Thailand
Authors: YAEMKONG SUPHAWADEE , NGOC TUAN NGUYEN 
Published: June 2019

Abstract. Yaemkong S, Tuan NN. 2019. Diversity of phenotypic characteristics of White Tailed-Yellow Chicken populations reared under free-range system in Phitsanulok Province, Thailand. Biodiversitas 20: 1264-1273. The objective of this study was to evaluate phenotypic diversity of White tail-yellow chickens in Mueang District, Phitsanulok, Thailand. A total of 200 male chickens from the purposive samples were collected, and then analyzed by using descriptive statistics, correlation and least squares mean for subclasses of each factor. The results showed that the phenotypic of White tail-yellow Chickens had the highest white-yellow beak (60.29%), hin comb (65.50%), golden-yellow neck plumage (95.69%), back plumage (96.17%) and wing plumage (67.94%), white-black long curving tails (70.11%), black back tails (71.14%) and white-yellow shank (59.81%) for qualitative traits. The quantitative traits such as body weight, body height, body length, body width, wing length, shank length, and toes length were 2.78±0.58 kg, 61.95±3.77 cm, 24.93±1.66 cm, 16.62±1.91 cm, 41.85±2.52 cm, 12.72±0.77 cm, and 8.39±0.66 cm, respectively. The highest positive correlation was recorded between neck plumage and back plumage (r=0.70; p<0.01). Moreover, body weight was the highest correlation with wing length (0.58; p<0.01) whereas body length was the highest positive correlation with wing plumage (0.21; p<0.01). However, beak and comb had no significant effect on all traits (p>0.05) except for neck, back and wing plumage, long curving tail, back tail and shank color (p<0.05).
Sociological Jurisprudence and Legal Realism as a Basis for the Development of Judicial Law-Making
Authors: ADYGEZALOVA Gyulnaz Eldarovna 
Published: June 2019

The aim of the present work is to study the role of sociological jurisprudence and legal realism for the development of judicial law making in the modern legal system. During the study, the author used general scientific methods, including historical, comparative, and logical ones. An analysis of legal documents was also performed, which allowed making conclusions about trends in the Russian legal system.
The study showed that sociological jurisprudence and the realistic school of law of the United States were milestones of the development of the same socio-legal school. It was determined that the supporters of sociological trends could be attributed to the moderate direction of the American sociological legal school, and the legal realists – to the radical one. The basis of the socio-legal school is formed by the ideas of pragmatism, which are expressed in the functional and instrumental approach to the law. One of the basic tenets of the proponents of socio-legal school is the following: the law shall harmonize the interests, actually act and be implemented in the activities of the court. Views of sociologists of law contributed to the approval of the idea of judicial law making not only within the Anglo-American legal family but also in the legal systems of the Romano-Germanic legal family. They drew attention to the process of decision-making by the court, the process of setting up the rule of law by the court.
The novelty of this research is that we have identified not only the influence of supporters of sociological school of law on the beginning of the new phase in the development of law, but also that the process was legitimate, and representatives of the scientific direction were able not only to recognize the pattern of ongoing legal development but also tried to steer the process in the right direction, so that the law would not lose its regulatory function and would not become a soulless mechanism in the hands of law enforcers.
Unjuk Kerja Separator Gas Liquid Cylindical Cyclone (GLCC Metering Loop)
Authors: Effendy Marwan 
Published: June 2019

Separator siklon silinder vertikal (Gas Liquid Cylindrical Cyclones) merupakan alat pemisahan aliran multifase yang umum dipergunakan dalam industri perminyakan. Penelitian ini bertujuan untuk mengevaluasi unjuk kerja dan perilaku hidrodinamika fluida separator GLCC metering loop pada pemisahan aliran campuran udara dan air. Eksperimen dilakukan dengan membuat separator skala uji laboratorium menggunakan pipa acrylic plexyglass diameter 6,25 cm, tinggi 140 cm dengan sistem inlet tangensial pada sudut inklinasi 30o, serta dilengkapi 5 variasi posisi saluran keluaran. Percobaan dilakukan dengan memvariasikan debit udara dan efek posisi saluran keluaran (recombination point). Beberapa aspek penting seperti kecepatan superficial gas (Vsg), kecepatan superficial cairan (Vsl), level cairan kesetimbangan (Leq), liquid carry over (LCO) dan gas carry under (GCU) menjadi perhatian selama percobaan. Hasil penelitian menunjukkan bahwa empat regim aliran yaitu aliran gelembung (bubble flow), aliran gelembung paket (packed bubble flow), aliran kantung gas atau sumbat cair (slug flow) dan aliran acak (churn flow) dipengaruhi oleh konfigurasi rasio aliran gas-cairan dan posisi rekombinasinya. Rasio kecepatan superfisial antara udara dan cairan memainkan peran penting terhadap terbentuknya regim aliran dan ketinggian level cairan kesetimbangan.
Second Order Segmented Polynomials for Syphilis and Gonorrhea Prevalence and Incidence Trends Estimation: Application to Spectrum’s Guinea-Bissau and South Africa Data
Authors: Guy Mahiane Severin , Pretorius Carel , Korenromp Eline 
Published: June 2019

Abstract
This paper presents two approaches to smoothing time trends in prevalence and estimating the underlying incidence of remissible infections. In the first approach, we use second order segmented polynomials to smooth a curve in a bounded domain. In the second, incidence is modeled instead and the prevalence is reconstructed using the recovery rate which is assumed to be known. In both approaches, the number of knots and their positions are estimated, resulting in non-linear regressions. Akaike Information Criterion is used for model selection. The method is illustrated with Syphilis and Gonorrhea prevalence smoothing and incidence trend estimation in Guinea-Bissau and South Africa, respectively.
Analyse von Patentdaten mittels Workflows und Big-Data-Technologien
Authors: Aras Hidir 
Published: June 2019

Zusammenfassung
In diesem Beitrag geht es um das interdisziplinäre Erlernen von Data Science u. a. im Rahmen von Aus- und Weiterbildungsmaßnahmen mittels interaktiver Lernumgebungen am Beispiel der Analyse großer Datenmengen mit Patentinformationen für neue Nutzergruppen wie z. B. den Informationsspezialisten, welche in der Regel über wenig bis keine Kenntnisse z. B. über Verfahren des maschinellen Lernens verfügen. Mittels einer interaktiven Lernumgebung auf Grundlage von Scientific Workflows und Big-Data-Technologien können dabei neue Methoden des Text und Data Mining (TDM) effizient erlernt und im Rahmen praktischer Anwendungsfälle erprobt werden.
Retractions from altmetric and bibliometric perspectives
Authors: Shema Hadas , Hahn Oliver , Mazarakis Athanasios , Peters Isabella 
Published: June 2019

Abstract
In the battle for better science, the research community must obliterate, at times, works from the publication record, a process known as retraction. Additionally, publications and papers accumulate an altmetric attention score, which is a complementary metric to citation-based metrics. We used the citations, Journal Impact Factor, time between publication and retraction and the reasons behind retraction in order to find determinants of the retracted papers´ altmetric attention score. To find these determinants we compared two samples, one of retractions with top altmetric attention scores and one of retractions with altmetric attention scores chosen at random. We used a binary choice model to estimate the probability of being retracted due to misconduct or error. The model shows positive effects of altmetric scores and the time between publication and retraction on the probability to be retracted due to misconduct in the top sample. We conclude that there is an association between retraction due to misconduct and higher altmetric attention scores within the top sample.
Fundamental Patents, National Intellectual Property Regimes, and the Development of New Industries in Britain and America during the Second Industrial Revolution
Authors: Scott Peter , Spadavecchia Anna 
Published: June 2019

Abstract
Several “new” industries of the second industrial revolution were characterised by one, or few, “fundamental” patents, without which manufacture of a viable product was not practicable. The degree of monopoly control that such patents conveyed was mediated by national socio-legal regimes, encompassing both patent law and its interpretation and enforcement. Using four case studies (two for the UK – a low anti-trust environment, and two for the USA – a high anti-trust environment) we show that fundamental patents were major determinants of monopoly power, industry structure, barriers to competition, and consumer prices. Impacts could extend beyond the life of the patents, owing to first mover advantages and path-dependent processes. Meanwhile national socio-legal environments, the nature of the fundamental patents, the strategies of the patent owners, and the nature of the specific product technology could have important (and sometimes unforeseen) consequences.