bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement in itch and other psoriasis symptoms with brodalumab in phase 3 randomized controlled trials
Authors: Gottlieb A.B. , Gordon K. , Hsu S. , Elewski B. , Eichenfield L.F. , Kircik L. , Rastogi S. , Pillai R. , Israel R. 
Published: March 2018

AbstractBackgroundPatients with psoriasis have lesional symptoms, including itch, which can reduce quality of life. The efficacy and safety of brodalumab, an interleukin‐17 receptor A antagonist, in treating moderate‐to‐severe psoriasis have been reported in three randomized, controlled, phase 3 trials (AMAGINE‐1/‐2/‐3).ObjectiveThe effect of brodalumab on lesional symptoms was assessed using the psoriasis symptom inventory (PSI), a validated patient‐reported instrument.MethodsPatients were randomized to receive brodalumab (140 or 210 mg every 2 weeks [Q2W]), placebo (AMAGINE‐1/‐2/‐3), or ustekinumab (AMAGINE‐2/‐3) during a 12‐week induction phase, followed by a maintenance phase through week 52. Patients electronically rated the severity of PSI items (itch, burning, stinging, pain, redness, scaling, cracking and flaking) during the previous 24 h on a scale of 0 (not at all severe) to 4 (very severe). At each visit, the PSI total score responder status was assessed, with responders defined as having an average weekly total inventory score ≤8 with no item score >1 at week 12.ResultsAcross AMAGINE‐1/‐2/‐3, brodalumab was associated with improvements in PSI total scores and itch scores vs. placebo from week 2 through week 12 (P < 0.001 in both domains). In AMAGINE‐2/‐3, brodalumab 210 mg Q2W demonstrated faster onset of PSI total score and itch responses (week 2, 22.1% and 36.4%, respectively) vs. ustekinumab (week 2, 6.9% and 17.1%, respectively) and was associated with improved itch responses vs. ustekinumab after 52 weeks of constant treatment.ConclusionBrodalumab demonstrated rapid, robust improvements in symptoms assessed by the PSI, including itch, vs. placebo and ustekinumab.
Agile Implementation: A Blueprint for Implementing Evidence‐Based Healthcare Solutions
Authors: Boustani Malaz , Alder Catherine A. , Solid Craig A. 
Published: March 2018

ObjectivesTo describe the essential components of an Agile Implementation (AI) process, which rapidly and effectively implements evidence‐based healthcare solutions, and present a case study demonstrating its utility.DesignCase demonstration study.SettingIntegrated, safety net healthcare delivery system in Indianapolis.ParticipantsInterdisciplinary team of clinicians and administrators.MeasurementsReduction in dementia symptoms and caregiver burden; inpatient and outpatient care expenditures.ResultsImplementation scientists were able to implement a collaborative care model for dementia care and sustain it for more than 9 years. The model was implemented and sustained by using the elements of the AI process: proactive surveillance and confirmation of clinical opportunities, selection of the right evidence‐based healthcare solution, localization (i.e., tailoring to the local environment) of the selected solution, development of an evaluation plan and performance feedback loop, development of a minimally standardized operation manual, and updating such manual annually.ConclusionThe AI process provides an effective model to implement and sustain evidence‐based healthcare solutions.
The Smithsonian Institution's “Greatest Treasures”: Valuing Museum Objects in the Specimen Exchange Industry
Authors: Nichols Catherine A. 
Published: March 2018

AbstractIn the nineteenth century, the exchange of anthropological specimens between museum curators and collectors was a widespread practice used to fill gaps in collections. Within the specimen exchange industry, one's ability to exchange required a steady supply of described or catalogued artifacts considered duplicates. Exchanging duplicates allowed anthropological specimens to move through institutional and personal scientific collections over time. Italian zoologist and anthropologist Enrico Giglioli relied on the practice of specimen exchange to build his personal collection of “stone age” tools from Indigenous peoples, sourced from a worldwide network of museums and collectors, including the Smithsonian Institution. As a master negotiator, Giglioli was remarkably successful in procuring valuable specimens from major museum collections. Analyses of the negotiation of exchanges by museum‐based anthropologists reveals the intersection of object value as produced by museums, agents' desire for rare and underrepresented objects, and professional standards of anthropological practice in the late nineteenth century. [exchange and value, duplicate, Smithsonian Institution, Enrico Giglioli]
Rhythm and melody as social signals for infants
Authors: Cirelli Laura K. , Trehub Sandra E. , Trainor Laurel J. 
Published: March 2018

AbstractInfants typically experience music through social interactions with others. One such experience involves caregivers singing to infants while holding and bouncing them rhythmically. These highly social interactions shape infant music perception and may also influence social cognition and behavior. Moving in time with others—interpersonal synchrony—can direct infants’ social preferences and prosocial behavior. Infants also show social preferences and selective prosociality toward singers of familiar, socially learned melodies. Here, we discuss recent studies of the influence of musical engagement on infant social cognition and behavior, highlighting the importance of rhythmic movement and socially relevant melodies.
Opioid and nondopamine reward circuitry and state‐dependent mechanisms
Authors: Fujita Masayo , Ide Soichiro , Ikeda Kazutaka 
Published: March 2018

AbstractA common notion is that essentially all addictive drugs, including opioids, activate dopaminergic pathways in the brain reward system, and the inappropriate use of such drugs induces drug dependence. However, an opioid reward response is reportedly still observed in several models of dopamine depletion, including in animals that are treated with dopamine blockers, animals that are subjected to dopaminergic neuron lesions, and dopamine‐deficient mice. The intracranial self‐stimulation response is enhanced by stimulants but reduced by morphine. These findings suggest that dopaminergic neurotransmission may not always be required for opioid reward responses. Previous findings also indicate the possibility that dopamine‐independent opioid reward may be observed in opioid‐naive states but not in opioid‐dependent states. Therefore, a history of opioid use should be considered when evaluating the dopamine dependency of opioid reward.
Mindfulness‐based weekend retreats for people bereaved by suicide (Panta Rhei): A pilot feasibility study
Authors: Scocco Paolo , Zerbinati Luigi , Preti Antonio , Ferrari Alessandro , Totaro Stefano 
Published: March 2018

ObjectivesThis study investigates whether a programme of mindfulness‐based weekend retreats (Panta Rhei) is able to improve mood states, mindfulness qualities, and self‐compassion in family members and friends of suicide victims (suicide survivors).DesignLongitudinal prospective study.MethodsSixty‐one suicide survivors participated in a mindful‐self‐compassion retreat. The Five‐Facet Mindfulness Questionnaire, the Profile of Mood States (POMS), and the Self‐Compassion Scale were administered 4–6 days before and after the retreat.ResultsA significant reduction in all dimensions of the POMS (except Vigor‐Activity) and lower levels of overidentification were observed after the retreat.ConclusionsAlthough further research is warranted, this study highlights the potential beneficial effect of brief mindfulness‐based weekend retreats on the well‐being of suicide survivors.Practitioner Points

Mindfulness‐based weekend retreats seem to be effective in alleviating the psychological distress of suicide survivors in the short term.

The benefit may depend on standard mindfulness practices and on more tailored interventions aimed at promoting acceptance of loss, forgiveness and rage management, and thus reducing rumination.

Since there is no established treatment for this population, this type of intervention, which seems feasible and well accepted by participants, paves the way for future research in this area.
Strategies and dental care in the treatment of patients with myelomeningocele
Authors: Bignardi Leticia , Prates Talita , De Rossi Andiara , Nelson‐Filho Paulo , de Carvalho Fabrício Kitasono , de Siqueira Mellara Talitha , de Queiroz Alexandra Mussolino 
Published: March 2018

ABSTRACTMyelomeningocele (MMC) is a congenital malformation that occurs in the embryonic period, characterized by failure in closure of the caudal portion of the neural tube during central nervous system formation. Alterations and complications can be associated with this condition, such as hydrocephalus, neurogenic bladder, orthopedic problems, and motor and cognitive impairment. This patients with MMC also have predisposition to develop latex allergy and high caries risk and activity due to deficient oral hygiene, fermentable carbon hydrate‐rich diet and prolonged use of sugar‐containing oral medications. This paper reports the oral findings and dental treatment in a 15‐year‐old female patient diagnosed with MMC and describes the strategies used to improve dental treatment conditions and reduce the impact of associated risks to her health. The measures and precautions adopted in this case could be useful to reduce the barriers for patients with the same condition to access oral health care: regular visits to the dentist, initiating as early as possible; frequent reinforcement of oral homecare instructions and diet counseling; minor adaptions to the dental chair and dental office to improve ease of access due to patients’ mobility problems; prevention of latex‐related allergic reactions; reduction of gag reflex during dental procedures.
Evaluation of Ceftolozane-Tazobactam in Combination with Meropenem against Pseudomonas aeruginosa Sequence Type 175 in a Hollow-Fiber Infection Model
Authors: Montero M. , VanScoy Brian D. , López-Causapé Carla , Conde Haley , Adams Jonathan , Segura Concepción , Zamorano Laura , Oliver Antonio , Horcajada Juan P. , Ambrose Paul G. 
Published: March 2018

ABSTRACT

The aim of this study was to investigate the efficacy of ceftolozane-tazobactam in combination with meropenem against an extensively drug-resistant (XDR)
Pseudomonas aeruginosa
high-risk clone, sequence type 175, isolated in a Spanish university hospital. A 14-day hollow-fiber infection model was used to simulate clinical exposure of the two drug regimens alone and in combination, and serial samples were collected to determine drug concentrations and CFU counts. The untreated control failed, as did each study regimen when administered alone. However, when ceftolozane-tazobactam was administered in combination with meropenem, there was a >4-log
10
CFU/ml bacterial density reduction and suppression of resistance for the duration of the study. These data suggest that ceftolozane-tazobactam plus meropenem may be a useful combination for treating XDR
P. aeruginosa
.
Complete Genome Sequence of Streptococcus suis Serotype 2 Virulent Strain SS2-1
Authors: Zhu Haodan , Ni Yanxiu , Zhou Junming , Yu Zhengyu , Mao Aihua , Wang Dandan , He Kongwang 
Published: March 2018

ABSTRACT

Streptococcus suis
is an important swine pathogen that can also cause severe diseases in humans. Herein, we describe the genome sequence of
Streptococcus suis
serotype 2 virulent strain SS2-1, which was isolated from a diseased dead pig amid the 1998
Streptococcus suis
outbreak in Jiangsu Province in China.
Draft Genome Sequence of Labrenzia sp. Strain EL143, a Coral-Associated Alphaproteobacterium with Versatile Symbiotic Living Capability and Strong Halogen Degradation Potential
Authors: Rodrigues Gisele Nunes , Lago-Lestón Asunción , Costa Rodrigo , Keller-Costa Tina 
Published: March 2018

ABSTRACT

We report here the genome sequence of
Labrenzia
sp. EL143, an alphaproteobacterium isolated from the gorgonian coral
Eunicella labiata
that possesses various genes involved in halogen and aromatic compound degradation, as well as polyketide synthesis. The strain also maintains multiple genes that confer resistance to toxic compounds such as heavy metals and antibiotics.
Potential Role for Regulatory B Cells as a Major Source of Interleukin-10 in Spleen from Plasmodium chabaudi-Infected Mice
Authors: Han Xue , Yang Ji , Zhang Yitong , Zhang Yalin , Cao Hongtao , Cao Yaming , Qi Zanmei 
Published: March 2018

ABSTRACT

Interleukin-10 (IL-10)-producing regulatory B (Breg) cells were found to be induced in a variety of infectious diseases. However, its importance in the regulation of immune response to malaria is still unclear. Here, we investigated the dynamics, phenotype, and function of Breg cells using
Plasmodium chabaudi chabaudi
AS-infected C57BL/6 and BALB/c mice. BALB/c mice were more susceptible to infection and had a stronger IL-10 response in spleen than C57BL/6 mice. Analysis of the surface markers of IL-10-producing cells with flow cytometry showed that CD19
+
B cells were one of the primary IL-10-producing populations in
P. c. chabaudi
AS-infected C57BL/6 and BALB/c mice, especially in the latter one. The Breg cells had a heterogeneous phenotype which shifted during infection. The well-established Breg subset, CD19
+
CD5
+
CD1d
hi
cells, accounted for less than 20% of IL-10-producing B cells in both strains during the course of infection. Most Breg cells were IgG
+
and CD138
−
from day 0 to day 8 postinfection. Adoptive transfer of Breg cells to C57BL/6 mice infected with
P. c. chabaudi
AS led to a transient increase of parasitemia without an impact on survival rate. Our finding reveals that B cells play an active and important regulatory role in addition to mediating humoral immunity in immune response against malaria, which should be paid more attention in developing therapeutic or vaccine strategies against malaria involving stimulation of B cells.
Measurement of oxygen extraction fraction by blood sampling to estimate severe cerebral hemodynamic failure and anticipate cerebral hyperperfusion syndrome following carotid artery stenting
Authors: Iwata Tomonori , Mori Takahisa , Tanno Yuhei , Kasakura Shigen , Yoshioka Kazuhiro 
Published: March 2018

BackgroundCerebral hyperperfusion syndrome (CHS) is likely to occur after carotid revascularization in patients with stage 2 hemodynamic failure (st2HF), in whom the oxygen extraction fraction (OEF) increases.ObjectiveThe purpose of our study was to investigate whether measurement of the global cerebral OEF (gcOEF) by blood sampling can be used to estimate st2HF and anticipate CHS following carotid artery stenting (CAS).MethodsThe OEF was calculated by blood sampling just before and after elective CAS. Data were collected prospectively. Patients who underwent elective CAS and gcOEF calculation were included in the study. Patients’ baseline features, pre-CAS gcOEF, post-CAS gcOEF, and incidence of CHS (defined as headache, seizure, focal neurologic deficits, and/or restlessness) were evaluated.Results141 patients met the inclusion criteria and 134 patients were analyzed. Median pre-CAS gcOEF and post-CAS gcOEF were 0.41 and 0.42, respectively. Nine patients developed CHS. Median pre-CAS gcOEF was higher in patients with than in those without CHS (Mann–Whitney U test, P<0.05), but median post-CAS gcOEF was not significantly higher in patients with CHS (P=0.058). Scattergrams of patients with and without CHS showed that the cut-off values of the pre-CAS gcOEF and post-CAS gcOEF for anticipation of CHS were 0.46 (P<0.01) and 0.49 (P<0.001), respectively.ConclusionElevation of the pre-CAS or post-CAS gcOEF by blood sampling allowed for anticipation of CHS following CAS. Elevation of the pre-CAS gcOEF might be associated with st2HF.
Periglacial complexes and the deductive evidence of ‘wet’-flows at the Hale impact crater, Mars
Authors: Soare R. J. , Conway S. J. , Gallagher C. , Dohm J. M. , Reiss D. 
Published: March 2018

Abstract

The Hale impact crater is a large complex crater (
c.
150 ×
c.
125 km) in the southern hemisphere of Mars. Recurring slope lineae have been observed on its central-peak slopes, as have relatively youthful gully-like landforms; the latter are observed adjacent to or in the midst of the former, as well as on all of the rim-material slopes. Three of the gullied slopes on the northern-rim materials exhibit landscape features that, on Earth, are synonymous with
wet
periglaciation, i.e. landscape modification by the freeze–thaw cycling of water. These features include: (1) gelifluction-like lobes; (2) patches of surface polygonization, possibly underlain by ice wedges and formed by thermal-contraction cracking; and (3) shallow, rimless and polygonized basins morphologically akin to terrestrial alases. Here, we use the spatial association of the gully-like landforms together with the putatively
wet
periglacial assemblages or complexes to deduce and ascribe, albeit indirectly, a wet origin to the former.
One hundred years of cross-country mobility prediction in Germany
Authors: Malm Florian 
Published: March 2018

Abstract
The potential for cross-country mobility (CCM) by vehicles has increasingly become an integral part of tactical planning for military operations and depends on a multitude of parameters. A comprehensive trafficability forecast requires the analysis of terrain, including slope, land cover and soil properties, and weather, as well as specific vehicle parameters. Terrain and weather interactions were recognized as important for the first time during World War I, when all types of vehicle would frequently bog down in muddy ground. The lessons learned influenced the orientation of future German military geology. During World War II, German military geologists and engineers prepared their first CCM maps. However, these often lacked a consistent format and standardized analysis. During the Cold War, the US Army carried out extensive research to create empirical mobility models based on physical properties and trafficability tests. These results were incorporated into the production of CCM maps. Present day computer-based data processing and analysis have opened up the possibility of enhancements to trafficability forecasting and thus make a vital contribution to providing the armed forces with advice on exercises and operations.
Groundwater supplies to maritime and coastal defences in southern England: a story of risk and innovation
Authors: Mather John D. 
Published: March 2018

Abstract
The viability of any fort or garrison depends on the availability of a reliable water supply. The source of choice is an underlying aquifer, reached by a secure on-site well or borehole. Unfortunately, at coastal and maritime sites, seawater intrusion can cause problems. In the late eighteenth century a deep well was sunk to supply the garrison at Sheerness, Kent, which successfully exploited sands beneath the London Clay. At Landguard Fort in Suffolk, a shallow gallery was designed to skim freshwater overlying saline water within loose sand and shingle. In the mid-nineteenth century, a network of forts was built to defend the Royal Dockyard at Portsmouth, which included some offshore forts on the Spithead shoals. Boreholes were drilled beneath these forts to abstract water from the Chalk thought to lie beneath. The Chalk proved to be at too great a depth, but the Bracklesham Group yielded a sustainable supply from <200 m. In carrying out these projects, military engineers sank wells and drilled speculative boreholes, taking financial risks, unacceptable in other parts of the public sector. They developed new technologies and their innovative ideas and discoveries led to an increased understanding of the distribution and use of groundwater.
Role of outer marginal collapse on salt deposition in the eastern Gulf of Mexico, Campos and Santos basins
Authors: Pindell James , Graham Rod , Horn Brian W. 
Published: March 2018

Abstract

Outer marginal collapse (OMC), a recently proposed process by which top-rift and base-salt unconformities formed near sea level may subside rapidly to 2.5–3 km at continental margins as mantle exhumation or seafloor spreading begins, needs further examination. We examine salt deposition at three margins and find that the differing positions and volumes of salt can be related to different durations of salt deposition as OMC and subsequent mantle exhumation proceed. Along NW Florida, salt is thin but deep and is interpreted as having formed at the start of OMC, before drowning further to abyssal depths. In the Campos Basin, salt is thick and extends across tens of kilometres of interpreted exhumed mantle, interpreted as having formed during the entire period of OMC before spreading onto mantle during exhumation. In the Santos Basin, salt is thick and extends across
c.
100 km of interpreted exhumed mantle and/or oceanic crust, arguably requiring ‘lateral tectonic accommodation’, whereby salt deposition persists near global sea level across the conjugated salt basin during mantle exhumation beneath mobile salt. The supposition that OMC can account for salt deposition in three different basins without invoking problematic 1.5–2 km-deep subaerial depressions provides further support for the process.
Accordance of Online Health Information on Prostate Cancer with the European Association of Urology Guidelines
Authors: Bruendl Johannes , Rothbauer Clemens , Ludwig Bernd , Dotzler Bernhard , Wolff Christian , Reimann Sandra , Borgmann Hendrik , Burger Maximilian , Breyer Johannes 
Published: March 2018

<b><i>Background:</i></b> The internet is an emerging source of information for prostate cancer (PCa) patients. Since little is known about the quality of information on PCa provided online, we investigated its accordance to the latest European Association of Urology (EAU) guidelines. <b><i>Methods:</i></b> A total of 89 German web pages were included for analysis. A quality model classifying the provider of information and its expertise was introduced. Correctness of provided information was systematically compared to the EAU guidelines. <b><i>Results:</i></b> Information was provided by medical experts (41%), media (11%), and pharmaceutical companies (6%). Certificates were found in 23% with a significantly higher rate if provided by medical experts (<i>p</i> = 0.003). The minority of web pages showed information in accordance with the EAU guidelines regarding screening (63%), diagnosis (32%), classification (39%), therapy (36%), complications (8%), and follow-up (27%). Web pages by medical experts as well as websites with any kind of certification showed a significantly higher guideline conformity regarding diagnosis (<i>p</i> = 0.027, <i>p</i> = 0.002), therapy (<i>p </i>= 0.010, <i>p</i> = 0.011), follow-up (<i>p</i> = 0.005, <i>p</i> &#x3c; 0.001), and availability of references (<i>p</i> = 0.017, <i>p</i> = 0.003). <b><i>Conclusions:</i></b> The present study reveals that online health information on PCa lacks concordance to current guidelines. Certified websites or websites provided by medical experts showed a significantly higher quality and accordance with guidelines.