bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovation strategies in CKD prevention and treatment – challenges, opportunities and sharing best practice
Authors: Kolesnyk M. 
Published: March 2019

Abstract. Chronic kidney disease (CKD) is a global public health problem, with cardiovascular disease being the major cause of mortality in these patients. CKD is associated with elevated risks of all-cause mortality and other adverse outcomes. This review is highlighting the consistency of the evidence about the hazards that are associated with CKD.
The challenge that clinicians now face is to search for CKD, to manage it aggressively, to evaluate novel means of detecting CKD and to expand the therapeutic strategies for patients with CKD. The evidence base for informing effective kidney care is limited, and the translation of existing knowledge to routine clinical care is slow.
Innovative approaches are described – patient-oriented care, complex care individualization, early screening for cognitive disorders, anxiety, renal education including education aids & e-Kidney application, teletechnology approach and CKD-self-testing in rural area, novel therapeutic targets for innovative CKD-oriented drugs, etc. Trials with the aim of re-purposing of generic therapeutics should be prioritized if sufficient scientific evidence is available. Furthermore, strategies used to extend patent life of drugs, but without investment to assess re-purposing, should be discouraged.
Finally, if the above goals are achieved, new therapies will certainly become available to stop, slow, or reverse CKD. These therapies should be made accessible to populations around the globe.
The level of vascular endothelial growth factor in peripheral blood of type 2 diabetic patients depending on kidney functional state
Authors: Topchii I. , Shcherban T. , Galchinska V. , Semenovykh P. , Savicheva K. 
Published: March 2019

Abstract. The aim of the study was to assess a serum level of vascular endothelial growth factor (VEGF) in type 2 diabetic patients depending on kidney function.
Methods: we examined 66 type 2 diabetic patients and 20 healthy control subjects. Depending on the presence of albuminuria and glomerular filtration rate (GFR) level, patients with diabetes mellitus (DM) were divided into the following groups: group I - patients with type 2 DM without signs of nephropathy – normal GFR without albuminuria (n = 26); group ІІ - patients with type 2 DM with normal GFR and albuminuria (n = 22); group III - patients with type 2 DM with reduced GFR and albuminuria (n = 18). ІV group - patients with acute coronary syndrome (n = 26).
The concentration of the VEGF was determined by enzyme-linked immunosorbent assay. The glomerular filtration rate (GFR) was calculated using the CKD EPI formula (KDIGO 2012).
Results: serum VEGF level in patients with diabetic nephropathy (DN) was significantly increased depending on kidney function.
VEGF positively correlated with urine albumin and serum creatinine levels and the negative correlation with GFR was found. These findings prove the undeniable role of kidneys in the development of renocardial syndrome in patients with DN. VEGF levels positively correlated with glycosylated hemoglobin and total cholesterol, indicating an unconditional dependence of endothelial dysfunction on lipid and glucose metabolism disorders.
Conclusions: Increased levels of VEGF in type 2 diabetic patients without clinical signs of kidney damage may indicate the development of subclinical renal dysfunction. Blood VEGF in patients with DN may be an integral marker of endothelial dysfunction and pathological angiogenesis. Our findings suggest that determination of serum VEGF level in patients with DN may have practical use as an early predictor of cardiac disruption, estimation of the prognosis, as well as improvement of cardionephroprotective strategy.
Bence-Jones protein as the form of nano-scaled β-stacked supramolecular aggregates
Authors: Voroshylova N. M. , Timchenko M. D. , Verevka S. V. 
Published: March 2019

Abstract. The formation in β-structured protein aggregates in tissues and fluids of the body is one of the most dangerouse complications of various diseases. The most famous of them are amyloidoses, but they such deposits are observed at other, much more widespread, diseases. The generally accepted approach to amyloids’detectionis based on high-specific coloring by Congo Red dye. However, the Abbe's diffraction limit excludes the seeing of the objects smaller than 0.61 wavelengths (about 240 nm). Such nanoscale formations are capable to disrup the functioning of surrounding tissues, to causethe complications and recurrences of the disease, and to pass through biological barriers with the following accumulation in body’s fluids. It’s likely that these conditions are the cause of the urinary congophilia, that is associated with preeclampsia at pregnancy and chronic kidney disease. Nor the less suspicious object is the Bens-Jones protein that appears in the urine at multiple myeloma and some other diseases, which are in more or less extent,are related to the disturbance of protein metabolism.
The purpose of this study was to clarify the aggregate state of the Bens-Jones protein as a possible β-structured supramolecular associate.
Methods.The subject of the study was the freshly received urine from a patient with multiple myeloma. The presence of the Bens-Jones protein was checked by thermopacification of the acidified sample. For control, the urine was used by a healthy person with the addition of certain amounts of human serum albumin ("Reanal", Hungary) with a concentration of 0, 0.01, 0.1 and 1%.
Result. The obtained data testify to the appropriateness of such a point of view and create preresquites for the expanding of diagnostic possibilities.
Conclusions.The results obtained during the study testify to the peculiarity of the structure of the Bens-Jones protein, which is nano-sized beta-structured supramolecular
A New Generation of Girls
Authors: Curzon Lucy D. 
Published: March 2019

BOOK REVIEWAnn Travers. 2018. The Trans Generation: How Trans Kids (and Their Parents) Are
Creating a Gender Revolution. New York: New York University Press.Ann Travers’s new book, The Trans Generation: How Trans Kids (and Their
Parents) Are Creating a Gender Revolution (hereafter The Trans Generation)
is a highly persuasive investigation that sheds much-needed scholarly light
on a grossly marginalized, precarious community. Travers interviewed 36
transgender children, and many of their parents, to reveal the challenges
they face in everyday use of bathrooms, locker rooms, and other rigidly gendered
spaces, as well as in interactions with friends, parents, and siblings, as
well as schools, and local and state or provincial governments. Apart from
the scope of this study, what is remarkable about The Trans Generation is its
accessibility. Instead of presenting a quantitative analysis, which can be alienating
to readers outside academia, Travers offers an exhaustive qualitative
study parsed in highly thoughtful, eloquent, and open terms—one that
prizes the individuality, indeed the knowableness, of each child interviewed.
And, although The Trans Generation is not explicitly dedicated to discussions
of girlhood, the focus of this journal, it nonetheless offers, I argue, valuable
new paradigms or strategies for thinking about girls’ lives and identities.
EFEKTIFITAS SOSIALISASI MAL OLEH KONSELOR ASI SEBAGAI SALAH SATU UPAYA PENCEGAHAN UNMEET NEED KB
Authors: Rosida Luluk 
Published: March 2019

Abstract Lactation amenorrhea method (LAM) is an alternative that can be used by women who experienced the unmet need for family planning to breastfeed cause delays recovery of fertility after childbirth and can be used as a natural contraceptive methods. The purpose of this study was to determine the effectiveness of the socialization of LAM by a breastfeeding counselor to efforts to reduce unmeet need in Yogyakarta. This quasi study uses the design of Non-Equivalent Control Group, which compares the return of menstruation to postpartum mothers with exclusive breastfeeding given LAM socialization by ASI counselors with postpartum mothers who were not given LAM socialization by ASI counselors. Women who are exclusively breastfeeding will in principle get longer menstrual initiation than those who do not exclusively breastfeed their babies. The sample in this study were mothers who had just given birth at the Community Health Center hospitalized in Yogyakarta. Bivariate analysis using the whtney man test. The results showed that there were differences in the return of menstruation in postpartum mothers who were given LAM socialization by ASI counselors with postpartum mothers who were not given LAM socialization.
Modern Nature for a Modern Nation:An Intellectual History of Environmental Dissonances in the Swedish Welfare State
Authors: Mårald Erland , Nordlund Christer 
Published: March 2019

Abstract
In the mid-1990s, the concept 'ecological modernisation' was established to characterise the perception that environmental protection and economic growth are not mutually exclusive but rather comprise a solid foundation for sustainable development. We argue in this essay that believing that modernisation, economic growth and a healthy environment could go hand-in-hand was nothing new as far as Sweden was concerned. Rather, it is a belief that developed during the 'folkhem era (1930s-1970s) due to an extensive dialogue about the proper relationship between nature and society in the construction of the welfare state. We highlight the idea of 'dissonances' as a salient metaphor describing the disharmonic relation between old and new and modern society and modern nature. According to advocates of modernisation, it was important to overcome dissonances - backwardness, inefficient use of natural resources and negative 'side effects' of societal progress such as pollution and environmental damage - between society and nature. Instead, by rational thinking and new technology it would be possible to make society and nature go hand-in-hand and thereby enhance human welfare. However, broadened knowledge and intellectual horizons and critiques of progress have brought new problem complexes and dissonances to light. Like the dream of Sweden the modern Model Nation, the definitive answer to the difficulties of the environmental issue has constantly been deferred.
Penerapan Metode PROMETHEE II Pada Pemilihan Situs Travel Berdasarkan Konsumen
Authors: Batubara Dinda Nabila , Sitorus P Dini Rizky , Windarto Agus Perdana 
Published: March 2019

Situs Travel merupakan tempat bagi Travel Agent untuk menawarkan jasa-jasa atau paket wisata mereka pada website berbasis online dan dengan situs travel, pelanggan tidak kesulitan dalam memesan paket wisata, mereka cukup memesan melalui smartphone tanpa harus ke biro travel agent. Banyaknya situs travel yang ada membuat para pelanggan bingung dan kesulitan dalam memilih situs travel yang tepat. Penelitian ini bertujuan untuk menganalisa situs travel yang tepat bagi konsumen dengan menerapkan metode PROMETHEE II. Data penelitian diperoleh dengan melakukan wawancara dan penyebaran angket secara random kepada 250 responden. Kriteria penilaian yang digunakan sebanyak 6: penilaian harga (C1), Pelayanan (C2), Interface (C3), Keamanan (C4), Promosi (C5), Sistem Pembayaran (C6) dan alternatif situs travel yang digunakan sebanyak 4: Traveloka (A1), Tiket.com (A2), Trivago (A3), Pegi-Pegi (A4). Hasil analisa menyebutkan bahwa PROMETHEE II dapat diterapkan dalam memilih situs travel dengan alternatif Tiket.com (A2) (net flow= 0.13) sebagai alternatif pertama dan alternatif pegi-pegi (A4) (net flow= 0.10) sebagai alternatif kedua.
Association of Serum Triglycerides and Total Cholesterol levels with Hypertension in Adult Female
Authors: Yeasmin Nahid , Akhter Qazi Shamima , Mahmuda Sayeeda , Nahar Sharmin , Abira Mahmuda , Rahman Farhana , Habib Tamanna Binte , Hasan Mahmudul , Yeasmin Shahanara 
Published: March 2019

Hyperlipidemia is one of the most widespread medical disorder in female and its complications are increasing all over the world, leading to life threatening medical problems like cardiovascular diseases, stroke and peripheral vascular diseases. An association between hyperlipidemia and hypertension has been identified. The study was carried out to observe the association of serum triglycerides and total cholesterol level with hypertension in adult female subjects. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. A total number of sixty female subjects were selected with age ranging from 30 to 50 years. Among them 30 female subjects with hypertension were included from the out-patient department of Medicine, Dhaka Medical College Hospital, Dhaka as study group (B) and 30 apparently healthy females were taken as control group (A) for comparison. Estimation of fasting serum triglycerides (TG) and total cholesterol (TC) levels were done by enzymatic method in the Department of Physiology, Dhaka Medical College Dhaka in both groups. Systolic blood pressure and diastolic blood pressure of all participants were recorded by standard method. Data were analyzed by Unpaired Student’s- test and Pearson's correlation co-efficient (r) test as applicable. The values of fasting serum TG level were significantly higher in subjects with hypertension than those of control. Fasting serum TC level was significantly higher in subjects with hypertension in comparison to controls also. In subjects with hypertension fasting serum TG and fasting serum TC levels were higher and showed positive correlation with systolic and diastolic blood pressure. Present study revealed that systolic and diastolic blood pressure has positive relationship with fasting serum triglyceride (TG) and fasting serum cholesterol (TC) levels.
Bangladesh Crit Care J March 2019; 7(1): 35-39
Status and Patients Satisfaction Attended at Emergency Department of a Tertiary Level Hospital in Dhaka City
Authors: Akhtar Khursheda , Rashid Md Mamun Or , Akhtar Khodeza , Siddika Ayesha , Siddika Syeda Subrina 
Published: March 2019

Background: Emergency department is one of the most important parts of a hospital which is the point of major public health interest.
Objective: The purpose of the present study was to find out the existing facilities of emergency department, to assess the satisfaction of patients and health care providers on emergency services.
Method: This cross-sectional study was carried out at emergency department of Mugda Medical College, Dhaka, Bangladesh from January 2017 to June 2017 for a period of six (06) months. Research instruments were semi structured questionnaire. Existing facilities at emergency department were assessed by check list which was adopted from Table of Equipment (TOE) by Directorate General of Health Service (DGHS) and satisfaction level was categorized as good and bad. Face to face interview was taken from emergency patients and health care providers attending in emergency unit.
Result: A total of 75 samples of respondents were selected purposively. Most of the respondents (30.0%) were in 26 to 35 years age group. According to their education level, 24(48.0%) were illiterate. Most of the respondents (76.0%) were attended to emergency unit by walking; however 48(96.0%) respondents attended by health care providers immediately. Half of the patients (50.0%) buy drugs from local dispensary and investigation in hospital was also done by half of the patients. After reaching at emergency, maximum patients 25(50.0%) waited for 1 to 5 minutes for receiving medical attention and mean waiting time was 10.14 minutes. Overall satisfactory level at emergency unit was good 23(46.0%) and bad 27(54.0%) (p<0.0001).
Conclusion: Numbers of potential barriers influence the patients’ satisfaction. Periodic patient satisfaction survey should be institutionalized to provide feedback for continuous quality improvement.
Journal of Current and Advance Medical Research 2019;6(1):53-58
Word-Level Translation Techniques in Medical Terms From English into Indonesian
Authors: Rongre Yohanis 
Published: March 2019

The aim of this study was to describe the use of translation techniques and the impact of the use of translation techniques on the accuracy and acceptability of medical terms in book of the Foundation Module: the midwife in the community. The method used in this research was a mixed method design, combining quantitative and qualitative approaches as it to discuss the quantification of the frequency of translation techniques used by the translator to translate medical terms and the impact of translation techniques applied on the accuracy and acceptability of the medical term translations. The source of data in this study is a book entitled Foundation Module: the midwife in the community and its Indonesian translation and 6 informants as well as a rater to assess the quality of medical terms translation. The results of this study showed that translation of medical terms of total 334 data dominated by naturalized borrowing 32.63%, calque 16.77% and description technique 8.38%. Meanwhile, quality assessment of the accuracy level of the translation showed a highly accurate 80.24% and assessment of acceptability 86.53%. Mostly the techniques used in translating medical terms give a positive influence for the accuracy and acceptability level of translation because the techniques used delivery the same information from the source language into the target language which is accepted linguistically.
Trigonometric Parallaxes of Star-forming Regions beyond the Tangent Point of the Sagittarius Spiral Arm
Authors: Wu 吴 Y. W. 元伟 , Reid M. J. , Sakai 坂 N. 井伸行 , Dame T. M. , Menten K. M. , Brunthaler A. , Xu 徐 Y. 烨 , Li 李 J. J. 晶晶 , Ho 胡 B. 波 , Zhang 张 B. 波 , Rygl K. L. J. , Zheng 郑 X. W. 兴武 
Published: March 2019

Abstract
As part of the BeSSeL Survey, we report trigonometric parallaxes and proper motions of molecular maser sources associated with 13 distant high-mass star-forming regions in the Sagittarius spiral arm of the Milky Way. In particular, we obtain improved parallax distance estimates for three well-studied regions:

for M17,

for W51, and

for GAL 045.5+00.0. Peculiar motions for all but one source are less than 20 km s−1. We fit a log-periodic spiral to the locations and estimate an average pitch angle of 7.°2 ± 1.°9. We find that the section of the arm beyond the tangent point in the first quadrant of the Milky Way appears 15 pc below the IAU-defined Galactic plane.
HARPS-N Solar RVs Are Dominated by Large, Bright Magnetic Regions
Authors: Milbourne T. W. , Haywood R. D. , Phillips D. F. , Saar S. H. , Cegla H. M. , Cameron A. C. , Costes J. , Dumusque X. , Langellier N. , Latham D. W. , Maldonado J. , Malavolta L. , Mortier A. , III M. L. Palumbo , Thompson S. , Watson C. A. , Bouchy F. , Buchschacher N. , Cecconi M. , Charbonneau D. , Cosentino R. , Ghedina A. , Glenday A. G. , Gonzalez M. , Li C-H. , Lodi M. , López-Morales M. , Lovis C. , Mayor M. , Micela G. , Molinari E. , Pepe F. , Piotto G. , Rice K. , Sasselov D. , Ségransan D. , Sozzetti A. , Szentgyorgyi A. , Udry S. , Walsworth R. L. 
Published: March 2019

Abstract
State-of-the-art radial-velocity (RV) exoplanet searches are currently limited by RV signals arising from stellar magnetic activity. We analyze solar observations acquired over a 3 yr period during the decline of Carrington Cycle 24 to test models of RV variation of Sun-like stars. A purpose-built solar telescope at the High Accuracy Radial-velocity Planet Searcher for the Northern hemisphere (HARPS-N) provides disk-integrated solar spectra, from which we extract RVs and

log

R

HK

′

. The Solar Dynamics Observatory (SDO) provides disk-resolved images of magnetic activity. The Solar Radiation and Climate Experiment (SORCE) provides near-continuous solar photometry, analogous to a Kepler light curve. We verify that the SORCE photometry and HARPS-N

log

R

HK

′

correlate strongly with the SDO-derived magnetic filling factor, while the HARPS-N RV variations do not. To explain this discrepancy, we test existing models of RV variations. We estimate the contributions of the suppression of convective blueshift and the rotational imbalance due to brightness inhomogeneities to the observed HARPS-N RVs. We investigate the time variation of these contributions over several rotation periods, and how these contributions depend on the area of active regions. We find that magnetic active regions smaller than 60 Mm2 do not significantly suppress convective blueshift. Our area-dependent model reduces the amplitude of activity-induced RV variations by a factor of two. The present study highlights the need to identify a proxy that correlates specifically with large, bright magnetic regions on the surfaces of exoplanet-hosting stars.
First Cosmology Results Using Type Ia Supernovae from the Dark Energy Survey: Photometric Pipeline and Light-curve Data Release
Authors: Brout D. , Sako M. , Scolnic D. , Kessler R. , D’Andrea C. B. , Davis T. M. , Hinton S. R. , Kim A. G. , Lasker J. , Macaulay E. , Möller A. , Nichol R. C. , Smith M. , Sullivan M. , Wolf R. C. , Allam S. , Bassett B. A. , Brown P. , Castander F. J. , Childress M. , Foley R. J. , Galbany L. , Herner K. , Kasai E. , March M. , Morganson E. , Nugent P. , Pan Y.-C. , Thomas R. C. , Tucker B. E. , Wester W. , Abbott T. M. C. , Annis J. , Avila S. , Bertin E. , Brooks D. , Burke D. L. , Rosell A. Carnero , Kind M. Carrasco , Carretero J. , Crocce M. , Cunha C. E. , Costa L. N. da , Davis C. , Vicente J. De , Desai S. , Diehl H. T. , Doel P. , Eifler T. F. , Flaugher B. , Fosalba P. , Frieman J. , García-Bellido J. , Gaztanaga E. , Gerdes D. W. , Goldstein D. A. , Gruen D. , Gruendl R. A. , Gschwend J. , Gutierrez G. , Hartley W. G. , Hollowood D. L. , Honscheid K. , James D. J. , Kuehn K. , Kuropatkin N. , Lahav O. , Li T. S. , Lima M. , Marshall J. L. , Martini P. , Miquel R. , Nord B. , Plazas A. A. , Roodman A. , Rykoff E. S. , Sanchez E. , Scarpine V. , Schindler R. , Schubnell M. , Serrano S. , Sevilla-Noarbe I. , Soares-Santos M. , Sobreira F. , Suchyta E. , Swanson M. E. C. , Tarle G. , Thomas D. , Tucker D. L. , Walker A. R. , Yanny B. , Zhang Y. ,   (DES COLLABORATION)
Published: March 2019

Abstract
We present griz light curves of 251 SNe Ia from the first 3 years of the Dark Energy Survey Supernova Program’s (DES-SN) spectroscopically classified sample. The photometric pipeline described in this paper produces the calibrated fluxes and associated uncertainties used in the cosmological parameter analysis by employing a scene modeling approach that simultaneously models a variable transient flux and temporally constant host galaxy. We inject artificial point sources onto DECam images to test the accuracy of our photometric method. Upon comparison of input and measured artificial supernova fluxes, we find that flux biases peak at 3 mmag. We require corrections to our photometric uncertainties as a function of host galaxy surface brightness at the transient location, similar to that seen by the DES Difference Imaging Pipeline used to discover transients. The public release of the light curves can be found at https://des.ncsa.illinois.edu/releases/sn.