bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is a pillow a risk factor for glaucoma?
Authors: van Meurs Ida A. , Thepass Gijs , Stuij Arthur A. , Bollemeijer Jan Geert , Lemij Hans G. 
Published: October 2018

AbstractPurposeTo study whether a clinically significant increase in intraocular pressure (IOP) occurs during simulated sleep conditions with the subject's head turned comfortably into a pillow (the simulated sleep position) and the effect of protective glasses on any such IOP rise.MethodsA specially developed electronic epipalpebral pressure (EPP) sensor was attached to an eyelid of the right eye of all participants: 11 patients with primary open‐angle glaucoma and 11 healthy volunteers. During calibration, mechanical pressure was applied to the EPP sensor taped to the lower eyelid and the IOP was measured simultaneously at the slit lamp by Goldmann applanation tonometry. The EPP was increased in a stepwise fashion to assess the relationship between EPP and IOP for each individual eye. Thereafter, EPP (with the sensor now taped to the upper eyelid) measurements were performed in the simulated sleep position, both with and without protective glasses. The EPP was determined in each individual eye, and the estimated IOP was then inferred from the established EPP/IOP relationship.ResultsIn the simulated sleep position, the mean IOP increased by an estimated 19.6 mmHg (SD: 7.5; range 11.6–32.8; p < 0.0001) in the patient group and 28.0 mmHg (SD: 9.6; range 12.3–41.1); p < 0.0001) in the control group. When the subjects wore protective glasses, the mean estimated IOP decreased again by 16.3 mmHg (SD: 5.6; range 9.8–28.1; p < 0.0001) in the patient group and 25.1 mmHg (SD: 8.2; range 11.7–38.3; p = <0.0001) in the control group.ConclusionTurning the head into a pillow gave a large and clinically significant increase in the estimated IOP in the simulated sleep position. With protective glasses, however, the increase in estimated IOP was almost absent. Therefore, protective shielding of the eyes during sleep may be a treatment option in glaucoma.
Outcomes of intraocular lens scleral fixation with the friction knot technique
Authors: Aaltonen Petri , Oskala Pertti , Immonen Ilkka 
Published: October 2018

AbstractPurposeTo examine the clinical outcomes of intraocular lens (IOL) scleral fixation with the friction knot technique.MethodsRetrospective case series of 152 eyes of 152 patients with inadequate capsular bag support operated with the friction knot IOL scleral fixation technique by a single surgeon. The fixated IOLs were one‐piece or three‐piece models all with open loop haptics. Main outcome measures were change in corrected distance visual acuity (CDVA) and postoperative complications.ResultsThe mean follow‐up time was 11.7 months (median 4.9, range 0.7–64.8). The mean logarithm of the minimum angle of resolution CDVA improved from preoperative 0.77 ± 0.73 (Snellen 20/118 ± 7.3 lines) to 0.44 ± 0.56 (Snellen 20/55 ± 5.6 lines) at the final visit (p < 0.001). The main postoperative complications were ocular hypertension (30.3%), uveitis–glaucoma–hyphaema syndrome (12.5%; UGHS), vitreous haemorrhage (11.2%) and retinal detachment (8.6%). Two (1.3%) cases of suture breakage were seen. In multivariate Cox regression analysis, age under 60 years [hazard ratio (HR) = 5.41; 95% confidence interval (CI) 1.95–15.01] and scleral fixated one‐piece IOL (HR = 4.23; 95% CI 1.44–12.44) were found as significant independent risk factors for developing new UGHS.ConclusionThe friction knot technique provides a firm scleral fixation. Scleral fixation may successfully be utilized in dislocated three‐piece IOLs with loop haptics. We recommend avoiding scleral fixation of one‐piece IOLs in young patients due to a high risk of UGHS.
Physicians’ views on patient participation in choice of oral anticoagulants in atrial fibrillation—a qualitative study
Authors: Aarnio Emma , Huupponen Risto , Hämeen‐Anttila Katri , Merikoski Merja , Puhakka Jaana , Korhonen Maarit J. 
Published: October 2018

AbstractDirect oral anticoagulants provide an alternative to vitamin K antagonists for the anticoagulation therapy in atrial fibrillation (AF). The availability of several treatment options with different attributes makes shared decision‐making appropriate for the choice of anticoagulation therapy. The aim of this study was to understand how physicians choose an oral anticoagulant (OAC) for patients with AF and how physicians view patients’ participation in this decision. Semi‐structured interviews with 17 Finnish physicians (eight general practitioners and nine specialists) working in the public sector were conducted. An interview guide on experience, prescribing and opinions about oral anticoagulants was developed based on previous literature. The data were thematically analysed using deductive and inductive approaches. Based on the interviews, patient's opinion was the most influential factor in decision‐making when there were no clinical factors limiting the choice between OACs. Of patient's preferences, the most important was the attitude towards co‐payments of OACs. Patients’ opinions on monitoring of treatment, dosing and antidote availability were also mentioned by the interviewees. The choice of an OAC in AF was patient‐centred as all interviewees expressed that patient's opinion affects the choice.
CEO letters: Social license to operate and community involvement in the mining industry
Authors: de‐Miguel‐Molina Blanca , Chirivella‐González Vicente , García‐Ortega Beatriz 
Published: October 2018

AbstractThis paper aims to analyse how the discourse of CEO letters and other factors influence community involvement and Social Licence to Operate (SLO) in the mining industry. The analysis is based on qualitative information disclosed in sustainability reports and CEO letters from 32 mining firms. Content analysis was undertaken to obtain data for the study, and then a regression analysis and a multiple correspondence analysis were used to test the hypotheses defined in the study. The results indicate that the CEO discourse influences how a firm expresses the importance of gaining its SLO, the philanthropic activities in which companies become involved and the destinations of the investments in the communities in which they operate. The results also show changes in the discourse between 2011 and 2015, which are, in part, explained by the difficult situation experienced by the sector during this period. The paper contributes to the Corporate Social Responsibility literature by integrating different theories from this field into the SLO framework. The analysis carried out and the results obtained are useful for both CEOs and Sustainability Managers, especially in managing their relationships with the communities where they operate or intend to operate.
Tamoxifen ameliorates obstructive nephropathy through Src and the PI3K/Akt/mTOR pathway
Authors: Kim Chang Seong , Kim In Jin , Choi Joon Seok , Bae Eun Hui , Ma Seong Kwon , Kim Soo Wan 
Published: October 2018

Background informationTubulointerstitial fibrosis is the end‐point of chronic kidney diseases. Tamoxifen, a selective oestrogen receptor (ER) modulator, attenuates renal fibrosis, by regulating the transforming growth factor (TGF)‐β/Smad signalling. Src and phosphoinositide 3‐kinase (PI3K)/Akt pathways play critical roles in the pathogenesis of renal fibrosis. However, the activation of the non‐canonical TGF‐β signalling in renal fibrosis after treatment with tamoxifen remains unclear. Renal fibrosis was induced by unilateral ureteral obstruction (UUO) in rats. Tamoxifen was orally administered after UUO. Additionally, HK‐2 cells were treated with tamoxifen in the presence or absence of TGF‐β1. The selective ER down‐regulator ICI and ER‐α silencing were used to confirm the involvement of ER‐α on the effect of tamoxifen on TGF‐β1‐stimulated fibrosis in HK‐2 cells.ResultsTamoxifen treatment ameliorated UUO‐induced renal fibrosis as shown by decreased expression of α‐smooth muscle actin (SMA), fibronectin and connective tissue growth factor (CTGF). The phosphorylation of Src, PI3K, Akt, mammalian target of rapamycin (mTOR) and p70S6K significantly decreased in UUO kidneys from tamoxifen‐treated animals. Tamoxifen dose‐dependently suppressed the TGF‐β1‐induced expression of α‐SMA and CTGF, and phosphorylation of Src, PI3K, Akt, mTOR and p70S6K in HK‐2 cells. These anti‐fibrotic effects were reversed by treatment with ICI and silencing of ER‐α. Moreover, inhibition of the PI3K/Akt and mTOR/p70S6K pathways was observed in HK‐2 cells co‐treated with PP1 (a Src kinase inhibitor) and tamoxifen.ConclusionsThe anti‐fibrotic effects of tamoxifen are associated with the suppression of Src kinase function via ER‐α, followed by inhibition of the PI3K/Akt and mTOR/p70S6K signalling pathways.SignificanceOur findings suggest that tamoxifen is a novel therapeutic option for the prevention and treatment of renal fibrosis.
Himalayan Boom Town: Rural–Urban Transformations in Namchi, Sikkim
Authors: McDuie‐Ra Duncan , Chettri Mona 
Published: October 2018

ABSTRACTNamchi, in the Indian state of Sikkim, is undergoing a building boom that is transforming a small district headquarters into an urban showpiece. Centred on religious theme parks and urban beautification, the boom captures Sikkim's emphasis on tourism as a development strategy. Growth in hydropower and pharmaceutical industries within the state, and infrastructure enabling this growth, seek to reduce dependency on the Indian government and have turned Sikkim into a ‘backyard’ for Indian capital. In contrast, Namchi epitomizes the transition from rural to urban space through tourism‐led growth, creating a ‘front yard’ exhibit which was recently awarded Smart City status despite its small size and relative unimportance. This article explores Namchi's boom by analysing the politics that drive it, the buildings and landscapes that capture its excess, and the town's lived urban spaces. The authors focus on three aspects of Namchi's boom: first, it is crucial for projections of success in Sikkim and aligns urban transformation with a particular vision of development actively promoted by the Chief Minister and ruling party; second, it is not based on resource extraction or agrarian expansion but on funds transferred to cultivate and reward loyalty in this border region; and third, it is drawing migrant workers to the town in large numbers, causing fissures and tensions, and simultaneously creating an emergent, though uneasy, cosmopolitanism.
Technical and vocational education and training in Uganda: A critical analysis
Authors: Okumu Ibrahim Mike , Bbaale Edward 
Published: October 2018

AbstractThis article undertakes a diagnostic study of the Technical and Vocational Education and Training (TVET) sub‐sector in Uganda, with a view to characterizing the sub‐sector and identifying its potential strengths and weakness. We undertook a cross‐sectional pre‐survey of purposively selected key stakeholders in the TVET sub‐sector. We selected performance indicators following their importance in influencing the TVET reform process. Both qualitative and quantitative data was solicited from the stakeholders. Quantitative data was collected through stakeholder‐specific structured questionnaires, whilst qualitative data was collected through desk review and field visits, individual focused interviews and focus group discussions. Our findings indicate that financing and planning constraints have resulted in poor quality equipment, under‐ and ill‐trained staff, limited adoption of a competence‐based education and training (CBET) curriculum, not to mention the supervision inadequacies of TVET institutions. Besides, the limited TVET sub‐sector interaction with the private sector has incapacitated TVET curriculum development to nurture skills demanded by the private sector. Furthermore, backward technology use in the private sector has equally inhibited the success of student attachment programmes. Finally, legal ambiguities have perpetuated a qualification jungle and overlapping curricula.
Identification of candidates for PFO closure in the echocardiography laboratory
Authors: Kerut Edmund Kenneth , Campbell William F. , Hall Michael E. , McMullan Michael R. 
Published: October 2018

A patent foramen ovale (PFO) is implicated in several pathologic processes, including that of cryptogenic stroke (cCVA). Recent trials identify “high‐risk” PFOs in patients with cCVA as likely to benefit from percutaneous closure. The younger the patient (<60 years old) the more likely a PFO may be attributable to the cCVA. The RoPE Score index helps determine the likelihood that an existing PFO is related to a cCVA. This may help guide the clinician and patient when contemplating percutaneous PFO closure. When evaluating a patient for possible percutaneous closure, one should identify the CVA as a typical ischemic type stroke. In order to “rule‐out” other causes of CVA, imaging of the intracranial arteries, cervical, and aortic arch vessels should be performed. Small vessel disease or a lacunar‐type infarct should be excluded. To rule out atrial fibrillation, prolonged monitoring should be performed. An index has been developed to determine the probability that a PFO is the causative etiology and calculates the risk of recurrence. This may help guide the clinician and patient in the decision for PFO closure. In addition, one should consider a work‐up for a hypercoagulable state. We will obtain an ultrasound of the lower extremities or consider deep pelvic vein thrombosis (prolonged sitting or malignancy). If the closure is to be performed, the Food and Drug Administration (FDA) has approved the Amplatzer PFO Occluder and the GORE Cardioform Septal Occluder for percutaneous closure. These devices are both approved in patients predominately between ages 18 and 60 years with a cCVA due to presumed paradoxical embolism as verified by a neurologist and cardiologist and when other causes of ischemic CVA have been excluded. “High‐risk” PFOs appear to achieve the most potential benefit from percutaneous closure.
Does rTMS reduce depressive symptoms in young people who have not responded to antidepressants?
Authors: Rosenich Emily , Gill Shane , Clarke Patrick , Paterson Tom , Hahn Lisa , Galletly Cherrie 
Published: October 2018

AimDepression is common in young people, and there is a need for safe, effective treatments. This study examined the efficacy of repetitive transcranial magnetic stimulation in a sample of young people aged 17 to 25 years.MethodsThis retrospective study included 15 people aged 17 to 25 years referred by their private psychiatrists affiliated with Ramsay Health Care, South Australia Mental Health Services. All patients met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for treatment‐resistant Major Depressive Disorder. Eleven patients received right unilateral treatment and four patients received bilateral treatment. Patients were assessed at baseline and after treatment.ResultsThere was a significant improvement on the Hamilton Rating Scale for Depression (t(14) = 4.71, P < 0.0001); Montgomery‐Åsperg Depression Rating Scale (t(14) = 3.96, P < 0.01) and the Zung Self‐Rating Depression Scale (t(14) = 4.13, P < 0.01). There was no difference in response by gender or age. The response rates in these young people did not differ significantly from those of adults aged 25 to 82 years.ConclusionThis open label, naturalistic study suggests that repetitive transcranial magnetic stimulation is an effective treatment in young adults who have treatment‐resistant depression. Randomized sham‐controlled studies are needed to further investigate the efficacy of this treatment in this age group.
Hedge fund leverage: 2002–2017
Authors: Liang Bing , Qiu Liping 
Published: October 2018

AbstractUsing a large panel data set, we investigate the dynamics of hedge fund leverage from 2002 to 2017 and find considerable variations in both time series and cross section. More than 70% of hedge funds use leverage and almost half of the leveraged funds are levered through margin borrowing. On average, hedge funds decreased leverage prior to the beginning of the financial crisis, with leverage remaining below the pre‐crisis levels. We find that the level of leverage and its changes are related to fund characteristics such as age, governance, performance, risk, fees, liquidity, survival, and the birth of a new fund.
Variable weight semantic graph‐based ontology mapping method
Authors: Yang Feng 
Published: October 2018

AbstractThe mapping method that is based on the name and structure of the ontology elements is the strategy used in most mapping methods. Methods using the name often only use the similarity between the individual elements in the ontology to predict the semantic relations between two ontologies, while the latter measure the mapping between two ontologies by means of the structural relations between the elements. The effects of these two kinds of mapping strategies are not ideal. Addressing this issue, the work presented in this paper proposes an ontology mapping approach, in which the ontology element name and structure are combined. It uses the approaches based on linguistics and distance to generate a variable weight semantic graph. On this graph, the similarity of element names and structure are calculated through iterative computation. In the process of iteration, similarity result values are constantly adjusted. The approach avoids the problem of single methods that cannot use the entire amount of ontology information; therefore, it provides a more ideal mapping result. For making full use of the message of ontology, our implementation and experimental results are provided to demonstrate the effectiveness of the mapping approach.
Direct and indirect impacts of pumping station operation on downstream migration of critically endangered European eel
Authors: Bolland Jonathan D. , Murphy Leona A. , Stanford Robert J. , Angelopoulos Natalie V. , Baker Nicola J. , Wright Rosalind M. , Reeds Jake D. , Cowx Ian G. 
Published: October 2018

AbstractDownstream passage of European eel Anguilla anguilla (L.) in catchments with pump(s) for water level management is a major concern. Catchment‐wide acoustic telemetry revealed silver eels quickly migrated downstream through unobstructed reaches (n = 12; mean ± SD = 17.9 ± 1.9 km/day). Fourteen of 17 acoustic‐tagged eels detected at the pumping station (82.1%) retreated back upstream and ten (58.8%) passed through pumps after delays (9.5 ± 11.0 days). Multi‐beam sonar imaging across the intake screen (55‐mm gaps) revealed that peaks in migration occurred during the nights preceding the new moon but 76.7% retreated back upstream. All passive integrated transponder (PIT)‐tagged eels recaptured (n = 56) downstream of a large (2.23‐m diameter) mixed flow pump survived but 96.5% had minor injuries, reduced physical condition and/or abnormal behaviour. By contrast, 64.7% of PIT‐tagged eels recaptured (n = 17) downstream of a small (0.8‐m diameter) axial flow pump died. No acoustic‐tagged eels that passed through the small axial flow pump (n = 10) performed onward migration at sea, unlike “control” eels released downstream (n = 11). This evidence may help develop effective remediation measures, such as operational changes, to maximise escapement of catadromous eel species at pumping stations.
Dunite channels within a harzburgite layer from the Horoman peridotite complex, Japan: Possible pathway for magmas
Authors: Yoshikawa Masako , Niida Kiyoaki , Green David H. 
Published: October 2018

AbstractTwo discordant dunite channels in a polished slab were collected from a harzburgite layer in the Horoman orogenic lherzolite massif, Hokkaido, Japan. The dunite channels show extreme grain‐size variations, and include very large olivine megacrysts up to 1.6 m long. Spinel‐rich pyroxenite veins or veinlets occasionally cross‐cut the olivine megacrysts. Mineral compositions differ between channels, and the mineral compositions and textures of the dunite channels and the host harzburgite suggest a replacive origin for the dunites. The Sr and Nd isotopic ratios of clinopyroxene separates from the pyroxenite veins in two dunite channels are different, but these ratios are generally similar to those of mid‐ocean ridge basalts. Assuming the channels formed by the through‐flow of melts, then the trace element compositions of the melts estimated from the clinopyroxenes are broadly similar. The melts have similar features such as enriched in incompatible elements and depleted in heavy rare earth elements, but there are differences in the depletions in Ti and Ba, indicating melts that were different but of similar origins. A Rb–Sr crystallization age (~ 52 Ma) was obtained for clinopyroxene–orthopyroxene pairs in a dunite channel and its host harzburgite. The distinctive dunite channels with megacrysts formed as a result of the through‐flow of mafic magma(s), and those magmas had trace and minor element contents that are indicative of contributions of a melt derived from subducted oceanic lithosphere.
Mineralogical characterization of the thrusted manganese ore above the Blackridge Thrust Fault, Kalahari Manganese Field: The footprint of the Mukulu Enrichment
Authors: Vafeas Nicholas A. , Viljoen Karel S. , Blignaut Lauren C. 
Published: October 2018

AbstractThe thrusted manganese ore above the Blackridge Thrust Fault is a predominantly unstudied ore‐type and as such, there is an urgent need to petrographically characterize it. A total of 80 samples were collected from the thrusted lower manganese ore bed of six boreholes on Mukulu in the north of the Kalahari Manganese Field. Each sample underwent a range of optical and electron petrographic analyses in order to effectively characterize three dominant stages of alteration, namely Stages 1, 2 and 3. Similar to the hydrothermally‐altered Wessels‐type manganese ore, braunite II is the predominant mineral phase present during Stage 1 alteration, and alters to bixbyite with increasing proximity to normal faults at the onset of Stage 2 alteration. The final stage of alteration is exhibited by the development of hausmannite and jacobsite adjacent to the ferruginised zone at the normal fault plane. Apatite precipitation, in abundances previously undocumented in the Kalahari Manganese Field, is a hallmark feature of the newly identified Mukulu Enrichment. This supergene‐related enrichment process contributed to the significant abundance of arsenic‐bearing apatite in the ore, whilst residually enriching the ore‐hosted Fe and Mn oxides.
Are prothrombin time and clot waveform analysis useful in detecting a bleeding risk in liver cirrhosis?
Authors: Ruberto Maria F. , Marongiu Francesco , Sorbello Orazio , Civolani Alberto , Demelia Luigi , Barcellona Doris 
Published: October 2018

AbstractIntroductionProthrombin time is thought to be unreliable in cirrhotic patients to predict the risk of bleeding. We investigated whether prothrombin time ratio was an independent risk factor for bleeding alongside its clot waveform analysis.MethodsWe studied 307 consecutive cirrhotic patients and 115 healthy subjects. A coagulometer was used for detecting both prothrombin time and clot waveform analysis which included velocity (1st derivative) and acceleration (2nd derivative) of clot formation, and area of parabolic segment of the 1st and 2nd derivatives of prothrombin time (entire cycle of the clot formation).ResultsLogistic regression shows that prothrombin time ratio was the only variable significantly associated with the history of bleeding. Using a hemorrhagic score, the stepwise model included prothrombin time ratio and the area of parabolic segment of the 1st derivative of Prothrombin Time. Odds ratio was used to create a new score to be challenged against the hemorrhagic score in a ROC analysis. The AUC was 0.72, 95% CI: 0.67‐0.77.ConclusionProthrombin time ratio is associated to an increased bleeding risk. Its role may be further emphasized considering clot waveform analysis. The new score, if aggregated to prothrombin time ratio, could be useful to provide a single parameter immediately ready to assess the bleeding risk in the individual cirrhotic patient.