bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, attitude, and practice of healthcare professionals regarding infection prevention at Gondar University referral hospital, northwest Ethiopia: a cross-sectional study
Authors: Yazie Teshiwal Deress , Sharew Gezahegn Bewket , Abebe Wondwossen 
Published: September 2019

AbstractObjectivesWorkplace health and safety is vital in every organization particularly in the healthcare settings. The aim was to assess the levels of knowledge, attitude, and practices of the healthcare professionals towards safety at Gondar University referral hospital. An institution based cross-sectional study was conducted from February to June 2018. Proportional random sampling technique was used to include 282 study participants and data were collected using a structured self-administered questionnaire and analyzed using SPSS version 20.ResultsAmong 282 study participants, 230 (81.6%), 181 (64.2%), and 162 (57.4%) had adequate knowledge, favorable attitude, and adequate practice scores, respectively. More than half (55.3%) of the study participants were untrained. There was a high (26.6%) prevalence of needlestick injury; however, the use of post-exposure prophylaxis after potential exposures was very limited. Generally, the levels of knowledge, attitude, and practice scores among the study participants were low. Therefore, there should be adequate and consistent supply of personal protective devices and other materials used for infection prevention and control. In addition, there should be awareness raising mechanism, including the provision of job aids and periodic training. Further, comprehensive studies should be conducted by including different types and levels of health facilities.
In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography
Authors: Notni Johannes , Gassert Florian T. , Steiger Katja , Sommer Peter , Weichert Wilko , Rummeny Ernst J. , Schwaiger Markus , Kessler Horst , Meier Reinhard , Kimm Melanie A. 
Published: September 2019

Abstract

Background
Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Joint inflammation and pathological growth of joint cartilage cause swollen and painful joints, which severely diminishes the patients’ life quality. There is no causal treatment. Symptomatic therapies should start as early as possible to take maximal effect. Hence, diagnostic procedures capable of detecting affected joints before the onset of clinical symptoms are highly desirable. We explored the value of PET imaging of integrin subtypes αvβ3 and α5β1 for early detection of RA foci in collagen-induced arthritis (CIA) mouse models.

Results
Development of RA in CIA mice was monitored by paw scoring, and αvβ3- and α5β1-integrin expression was quantified by μPET using 68Ga-Avebetrin and 68Ga-Aquibeprin. For consecutive sections of selected decalcified joints (knee, ankle), arthritic degeneration and integrin expression were assessed by MOVAT staining and β3/α5 immunohistochemistry (IHC), respectively. β3- and α5-IHC revealed elevated levels of both αvβ3- and α5β1-integrin in arthritic joints. Unlike αvβ3, α5β1 is strongly expressed in the proliferating synovial lining layer, which suggests that its presence is directly related to RA development. For mice with advanced RA (6 weeks after CIA), PET signals for α5β1-integrin were substantially stronger (> 300% of baseline) than that of αvβ3-integrin (< 200%). A longitudinal PET follow-up revealed that the manifestation of clinical symptoms of RA is preceded by upregulation of α5β1- but not of αvβ3-integrin.

Conclusion
α5β1-integrin PET could add a new functional imaging aspect to the portfolio of RA diagnostics because it appears to be a sensitive biomarker for early RA development. We suggest α5β1-integrin PET as a valuable tool to achieve a higher precision for early diagnosis of RA, including initial staging, monitoring of the disease course, and drug treatment, and for planning of radiosynoviorthesis (RSO).
Robust visual tracking via samples ranking
Authors: Zhu Heyan , Wang Hui 
Published: September 2019

AbstractIn recent years, deep convolutional neural networks (CNNs) have achieved great success in visual tracking. To learn discriminative representations, most of existing methods utilize information of image region category, namely target or background, and/or of target motion among consecutive frames. Although these methods demonstrated to be effective, they ignore the importance of the ranking relationship among samples, which is able to distinguish one positive sample better than another positive one or not. This is especially crucial for visual tracking because there is only one best target candidate among all positive candidates, which tightly bounds the target. In this paper, we propose to take advantage of the ranking relationship among positive samples to learn more discriminative features so as to distinguish closely similar target candidates. In addition, we also propose to make use of the normalized spatial location information to distinguish spatially neighboring candidates. Extensive experiments on challenging image sequences demonstrate the effectiveness of the proposed algorithm against several state-of-the-art methods.
Approximation by a generalized class of Dunkl type Szász operators based on post quantum calculus
Authors: Alotaibi Abdullah 
Published: September 2019

AbstractThe main purpose of this paper is to introduce a generalized class of Dunkl type Szász operators via post quantum calculus on the interval$[ \frac{1}{2},\infty )$[12,∞). This type of modification allows a better estimation of the error on$[ \frac{1}{2},\infty ) $[12,∞)rather than$[ 0,\infty )$[0,∞). We establish Korovkin type result in weighted spaces and also study approximation properties with the help of modulus of continuity of order one, Lipschitz type maximal functions, and Peetre’sK-functional. Furthermore, we estimate the degrees of approximations of the operators by modulus of continuity of order two.
An optimal equilibrium for a reformulated Samuelson economic discrete time system
Authors: Barros Maria Filomena , Ortega Fernando 
Published: September 2019

Abstract
This paper studies the equilibrium of an extended case of the classical Samuelson’s multiplier–accelerator model for national economy. This case has incorporated some kind of memory into the system. We assume that total consumption and private investment depend upon the national income values. Then, delayed difference equations of third order are employed to describe the model, while the respective solutions of third-order polynomial correspond to the typical observed business cycles of real economy. We focus on the case that the equilibrium is not unique and provide a method to obtain the optimal equilibrium.
Autoimmune rhabdomyolysis and a multiorgan display of PD-1 inhibitor induced immune related adverse events during treatment of metastatic melanoma
Authors: Pourhassan Hoda Z. , Tryon David , Schaeffer Brett , Mirshahidi Hamid , Wong John 
Published: September 2019

Abstract

Background
Programmed death-1 (PD-1) inhibitors are among the immunotherapies that have revolutionized our approach to treating several cancers. These novel agents act by blocking PD-1 receptor/PD-1 ligand interactions that would otherwise allow tumor cells to evade host immune destruction by inhibiting response of cytotoxic T-lymphocytes. They are overall well tolerated, though they have been associated with a constellation of immune mediated adverse events (irAEs).

Case presentation
We present a case of rare nivolumab mediated adverse events in a patient with nodular recurrence of melanoma. The patient presented with rhabdomyolysis and shortly thereafter developed a constellation of immune-mediated organ derangements. This case further demonstrates the utility and effectiveness of steroid therapy in the setting of irAEs despite our patient’s eventual poor clinical outcome. While PD-1 inhibitors have revolutionized the treatment of several cancers, they require vigilance by the clinician for early detection and treatment of uncommon but potentially fatal irAEs.

Conclusions
PD-1 inhibitors are now widely used in a multitude of cancer types including melanoma, advanced non-small cell lung cancer, metastatic renal cell carcinoma, and Hodgkin lymphoma amongst others. While these agents are often well tolerated, they are associated with a unique profile of immune-related toxicities that can cause significant morbidity and mortality. Education of both patients and healthcare providers is essential for diagnosis and treatment of these adverse events early in their course. This case highlights the uncommon but potentially serious PD-1-associated toxicity of myopathy and rhabdomyolysis along with other organ involvement and is directly applicable to use of these agents in patients with advanced cancers.
Morphometric evaluation of bone regeneration in segmental mandibular bone defects filled with bovine bone xenografts in a split-mouth rabbit model
Authors: Soares Mariana Quirino Silveira , Van Dessel Jeroen , Jacobs Reinhilde , Yaedú Renato Yassutaka Faria , Sant’Ana Eduardo , da Silva Corrêa Danilo , Madeira Maria Fernanda Conceição , Duarte Marco Antônio Húngaro , Rubira-Bullen Izabel Regina Fischer 
Published: September 2019

Abstract

Background
Bovine bone grafts have been widely used in dentistry for guided tissue regeneration and can support new bone formation in direct contact with the graft. The aim of this study was to compare the morphometric and bone density changes after using two different bovine bone graft blocks in segmental osseous defects in the mandible of rabbits following different postoperative periods.

Material and methods
Critical size segmental defects were surgically created bilaterally in the jaw of 18 rabbits. The defects were filled with either deproteinized bovine bone mineral with 10% collagen (DBBM-C; BioOss Collagen®), lyophilized bovine medullary bone (LBMB; Orthogen®), or left untreated according to a split-mouth design. Animals were sacrificed after 3 or 6 months of healing. The hemimandibles were scanned ex vivo using a high-resolution (19 μm) microcomputed tomography. Morphometric and bone density parameters were calculated in the region of the defect using CT-Analyser (Bruker). Initial graft blocks were used as baseline.

Results
DBBM-C presented a denser microarchitecture, in comparison to LBMB at baseline. DBBM-C and LBMB grafted regions showed a similar progressive remodeling, with a significant decrease in structure complexity and maintenance of bone volume fraction during the postoperative follow-up periods. Both graft materials showed an enhanced bone replacement and more complex structure compared to untreated defects. The apparent fusion between the graft and host bone was observed only in the defects filled with LBMB.

Conclusion
LBMB grafts showed a similar behavior as DBBM-C regarding structural remodeling. In LBMB samples, apparent integration between the host bone and the graft was present.
Low Abundance of Circulating Tumor DNA in Localized Prostate Cancer
Authors: Hennigan S. Thomas , Trostel Shana Y. , Terrigino Nicholas T. , Voznesensky Olga S. , Schaefer Rachel J. , Whitlock Nichelle C. , Wilkinson Scott , Carrabba Nicole V. , Atway Rayann , Shema Steven , Lake Ross , Sweet Amalia R. , Einstein David J. , Karzai Fatima , Gulley James L. , Chang Peter , Bubley Glenn J. , Balk Steven P. , Ye Huihui , Sowalsky Adam G. 
Published: September 2019

PURPOSE Despite decreased screening-based detection of clinically insignificant tumors, most diagnosed prostate cancers are still indolent, indicating a need for better strategies for detection of clinically significant disease before treatment. We hypothesized that patients with detectable circulating tumor DNA (ctDNA) were more likely to harbor aggressive disease. METHODS We applied ultra-low-pass whole-genome sequencing to profile cell-free DNA from 112 patients diagnosed with localized prostate cancer and performed targeted resequencing of plasma DNA for somatic mutations previously identified in matched solid tumor in nine cases. We also performed similar analyses of data from patients with metastatic prostate cancer. RESULTS In all cases of localized prostate cancer, even in clinically high-risk patients who subsequently had recurrent disease, ultra-low-pass whole-genome sequencing and targeted resequencing did not detect ctDNA in plasma acquired before surgery or before recurrence. In contrast, using both approaches, ctDNA was detected in patients with metastatic prostate cancer. CONCLUSION Our findings demonstrate clear differences between localized and advanced prostate cancer with respect to the dissemination and detectability of ctDNA. Because allele-specific alterations in ctDNA are below the threshold for detection in localized prostate cancer, other approaches to identify cell-free nucleic acids of tumor origin may demonstrate better specificity for aggressive disease.
Εκπαιδευτικές δραστηριότητες σε επιφανειακά ύδατα με την αξιοποίηση του Διαδικτύου των Αντικειμένων
Authors: ΤΖΙΩΡΤΖΙΩΤΗ ΧΡΥΣΑΝΘΗ , ΜΑΥΡΟΜΜΑΤΗ ΕΙΡΗΝΗ , ΧΑΤΖΗΓΙΑΝΝΑΚΗΣ ΙΩΑΝΝΗΣ , ΑΜΑΧΙΛΑΤΗΣ ΔΗΜΗΤΡΗΣ 
Published: September 2019

Το υδατικό περιβάλλον διαδραματίζει έναν εξόχως σημαντικό ρόλο για την ύπαρξη της ζωής στη Γη. Ωστόσο, τα υδατικά οικοσυστήματα κινδυνεύουν άμεσα από την ολοένα αυξανόμενη ρύπανση, την κλιματική αλλαγή και την απώλεια της βιοποικιλότητας, με αποτέλεσμα να καθίσταται κάτι περισσότερο από απαραίτητη η διαρκής, όσο και λεπτομερής παρακολούθησή τους. Σε αυτή την εργασία, παρουσιάζεται η εφαρμογή μιας εκπαιδευτικής πρακτικής STEM που αξιοποιεί συστήματα Διαδικτύου των Αντικειμένων με αισθητήρες (Internet of Things, IoT), σε συνδυασμό με κατάλληλα σχεδιασμένες εκπαιδευτικές δραστηριότητες που βασίζονται στη Μάθηση μέσω Σχεδιασμού (Design Based Learning), για την κατανόηση του υδάτινου περιβάλλοντος. Συγκεκριμένα, περιγράφεται ο σχεδιασμός και η λειτουργία ενός αυτοματοποιημένου συστήματος, το οποίο αξιοποιεί δεδομένα αισθητήρων εγκατεστημένων σε λίμνες και ποτάμια, για την παρακολούθηση και καταγραφή των περιβαλλοντικών παραμέτρων. Μέσα από την προσπάθεια ευαισθητοποίησης της σχολικής κοινότητας σε θέματα προστασίας της ποιότητας των υδάτων ως αποτέλεσμα εκπαιδευτικών δραστηριοτήτων STEM, στις οποίες εφαρμόζονται οι γνώσεις των φυσικών επιστημών, της τεχνολογίας, της μηχανικής και των μαθηματικών, οι μαθητές στοχεύουν: α) στη γνώση και κατανόηση των βασικών φυσικών και χημικών παραμέτρων του νερού υδατικών οικοσυστημάτων, και β) στην ικανότητα συσχετισμού, ερμηνείας και εκτίμησης των μεταβολών των φυσικών και χημικών παραμέτρων του νερού.
Pre-release assessment of Javan Gibbon (Hylobates moloch) during acclimatization phase in Mount Malabar Protected Forest, West Java
Authors: Ario Anton , Kartono Agus Priyono , Prasetyo Lilik Budi , Supriatna Jatna 
Published: September 2019

Pre-release aassessment study of Javan gibbon (Hylobates moloch) in gradually during acclimatization phase in the Mount Malabar Protected Forest, West Java. We studied eleven Javan gibbons in February-March 2014, February-March 2015, March-April 2015, and July-August 2016. The purpose of this study was to assess the readiness of Javan gibbon behavior in acclimatization phase prior to release. Data collection was conducted by focal animal sampling method with 5-minute interval recording time and ad libitum method. The average time allocation of Javan gibbon activities were the following: feeding 16.82±1,28%; moving 20.01±3.14%; resting 47.64±1.31%; socializing 12.88±2.92%; sexual 0.69±0.54%; and vocalizing 1.96±0.59%. We compared activity allocation data from this study and those from wild Javan gibbons and found similarities as follows: 55.30% at a family of Jowo-Bombom-yani-Yudi, 51.42% at a pair of Moly-Nancy, 44.57% at a pair of Robin-Moni and 62.19% at a family of Mel-Pooh-Asri. Based on readiness assessment of 11 Javan gibbons, 3 were considered almost ready for release, while 8 individuals were considered ready.
Perancangan Pesan untuk Meningkatkan Intensi Perilaku Hemat dalam Menggunakan Air
Authors: Sari Hasrini , Gantini Ratna Dewi 
Published: September 2019

Ketersediaan potensi air bersih di Indonesia menurun, sehingga kontribusi dari semua pihak diperlukan untuk mengatasi masalah ini. Salah satunya adalah dengan mendorong perilaku hemat air dari penggunanya melalui pemaparan pengetahuan atau pemahaman tentang kondisi ketersediaan air dan kualitas air di masa sekarang dan di masa depan. Upaya mendorong orang untuk menggunakan air secara bijak dapat dilakukan dengan menyampaikan pesan yang dirancang dengan baik. Penelitian ini bertujuan untuk mengidentifikasi karakteristik pesan yang efektif untuk mendorong masyarakat menjadi lebih hemat dalam menggunakan air dengan mengadopsi Hierarchy of Effect Model dan metode anchor.Pesan akan mempengaruhi penerima secara bertahap mulai dari aspek kognitif, afektif dan niat. Sementara anchordigunakan dalam pesan untuk menciptakan keadaan pikiran yang diinginkan untuk meningkatkan efektivitas pesan yang disampaikan. Metode penelitian yang digunakan adalah desain eksperimen. Dalam penelitian pendahuluan, ditemukan bahwa stimulus yang mengandung isi pesan yang memberikan efek takut memiliki tingkat yang signifikan dalam mempengaruhi intensi partisipan. Eksperimen pertama dari penelitian utama membuktikan hubungan hirarkis antara aspek kognitif, afektif dan intensi. Eksperimen kedua dari penelitian tersebut menemukan bahwa jenis konten pesan yang dapat meningkatkan niat masyarakat untuk menggunakan air dengan bijaksana adalah jenis konten pesan yang menimbulkan efek takut terhadap konsekuensi dari penggunaan air yang berlebihan.
The Running and Technical Performance of U13 to U18 Elite Japanese Soccer Players During Match Play
Authors: Goto Heita , Saward Chris 
Published: September 2019

Abstract
Goto, H and Saward, C. The running and technical performance of U13 to U18 elite Japanese soccer players during match play. J Strength Cond Res 34(6): 1564–1573, 2020—The aims of the current study were (a) to examine age-related differences in match running performance with 2 different approaches (speed vs. metabolic power) in U13–U18 Japanese elite soccer players and (b) to examine age-related differences in technical match performance in U13–U18 Japanese elite soccer players. Participants were 110 outfield players from academies of 2 professional soccer clubs in Japan. Forty-eight 11-a-side official league matches (13, 6, 9, 7, 6, and 7 matches for U13, U14, U15, U16, U17, and U18 age-groups, respectively) were analyzed (152 complete match files). Global positioning system (15 Hz) and video analysis were used to analyze running and technical performance during matches, respectively. Total distance covered in absolute terms (U13 < [U14 and U15] < [U16–U18]; p < 0.05 for all), high-intensity running distance ([U13–U15] < [U16–U18]; p < 0.05 for all), and distance covered during the metabolic power zone of ≥35 W·kg−1 relative to match playing time ([U13 < U16], [U13–U15] < [U17 and U18]; p < 0.05 for all) increased with age. The speed zone based approach (high-intensity running distance, ≥4.0 m·s−1) underestimated high-intensity demands compared with the metabolic power zone based approach (≥20 W·kg−1) by ∼33 to ∼57% (p < 0.01 for all), with the underestimation declining with age (p < 0.001). Pass accuracy improved with age from 73% at U13 to 85% at U18 (p < 0.001). Therefore, distance covered at high speeds and at high metabolic powers, and pass accuracy increase with age. Moreover, the speed zone based approach underestimates the demands of match play in Japanese elite youth soccer players. The current results could support coaches to develop players, identify talent, and produce age-specific training programs.
Neural Correlates of Music Listening and Recall in the Human Brain
Authors: Ding Yue , Zhang Yang , Zhou Wenjing , Ling Zhipei , Huang Juan , Hong Bo , Wang Xiaoqin 
Published: September 2019

Previous neuroimaging studies have identified various brain regions that are activated by music listening or recall. However, little is known about how these brain regions represent the time course and temporal features of music during listening and recall. Here we analyzed neural activity in different brain regions associated with music listening and recall using electrocorticography recordings obtained from 10 epilepsy patients of both genders implanted with subdural electrodes. Electrocorticography signals were recorded while subjects were listening to familiar instrumental music or recalling the same music pieces by imagery. During the onset phase (0–500 ms), music listening initiated cortical activity in high-gamma band in the temporal lobe and supramarginal gyrus, followed by the precentral gyrus and the inferior frontal gyrus. In contrast, during music recall, the high-gamma band activity first appeared in the inferior frontal gyrus and precentral gyrus, and then spread to the temporal lobe, showing a reversed temporal sequential order. During the sustained phase (after 500 ms), delta band and high-gamma band responses in the supramarginal gyrus, temporal and frontal lobes dynamically tracked the intensity envelope of the music during listening or recall with distinct temporal delays. During music listening, the neural tracking by the frontal lobe lagged behind that of the temporal lobe; whereas during music recall, the neural tracking by the frontal lobe preceded that of the temporal lobe. These findings demonstrate bottom-up and top-down processes in the cerebral cortex during music listening and recall and provide important insights into music processing by the human brain.SIGNIFICANCE STATEMENTUnderstanding how the brain analyzes, stores, and retrieves music remains one of the most challenging problems in neuroscience. By analyzing direct neural recordings obtained from the human brain, we observed dispersed and overlapping brain regions associated with music listening and recall. Music listening initiated cortical activity in high-gamma band starting from the temporal lobe and ending at the inferior frontal gyrus. A reversed temporal flow was observed in high-gamma response during music recall. Neural responses of frontal and temporal lobes dynamically tracked the intensity envelope of music that was presented or imagined during listening or recall. These findings demonstrate bottom-up and top-down processes in the cerebral cortex during music listening and recall.
The Correlation between self-efficacy and iron tablets consuming of Pregnant Women in Garut District
Authors: Puspita Tantri , Jerayingmongkol Peranan , Sanguanprasit Boosaba 
Published: September 2019

Maternal health during pregnancy is important not only for the mothers but also for the infant. Anemia status is a condition that may cause a death against pregnant women. Consuming iron tablet lead pregnant women to prevent anemia. The purpose of this study was to identify the relationship between self-efficacy and consuming iron tablet during pregnancy. This study was a secondary analysis from previous study which included 263 pregnant women in the analysis. The pregnant women were in 5 Public Health Care area in Garut District. The Data were collected using self-administered questionnaire. The result revealed that more than 50 % participant were confident and highly confident of taking iron tablets. Amount 22% of them were always consumed the iron tablet as they daily supplement. There was moderate correlation between self-efficacy and iron tablet consuming of pregnancy women in Garut District (r =407, α< 0,01). Health care providers are recommended to enhance pregnant women iron tablet consuming by improve their self-efficacy. It also can include their family as their motivator of improving self-efficacy to consume iron tablets.