bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real World Patient-reported Outcomes in HIV-infected Adults Switching to EVIPLERA®, Because of a Previous Intolerance to cART. PRO-STR Study
Authors: Podzamczer D. , Rozas N. , Domingo P. , Miralles C. , den Eynde E. Van , Romero A. , Deig E. , Knobel H. , Pasquau J. , Antela A. , Clotet B. , Geijo P. , de Castro E. Rodríguez , Casado M.A. , Muñoz A. , Casado A. , for the PRO-STR STUDY GROUP  
Published: February 2019

Background:
To investigate the impact of switching from stable Combined Antiretroviral
Therapy (cART) to single-tablet regimen (RPV/FTC/TDF=EVIPLERA®
/COMPLERA®) on patient-reported outcomes in HIV-infected adults who cannot tolerate previous cART, in a real-world
setting.

Methods:
PRO-STR is a 48-week observational, prospective, multicenter study. Presence and magnitude
of symptoms (main endpoint), health-related quality-of-life (HRQoL), adherence, satisfaction
with treatment and patient preferences were assessed.

Results:
Three hundred patients with 48-week follow-up, who switched to EVIPLERA® (mean age:
46.6 years; male: 74.0%; 74.7% switched from a non-nucleoside reverse-transcriptase-inhibitor,
25.3% from a protease inhibitor + ritonavir) were included. There was no statistical difference in
median CD4+ cell count (baseline: 678.5 cells/mm3; 48-week: 683.0 cells/mm3) neither in virological
suppression (≤50 copies/mL) (baseline: 98.3%; 48-week: 95.3%). The most frequent reasons for
switching were neuropsychiatric (62.3%), gastrointestinal (19.3%) and biochemical/metabolic
(19.3%) events. Only 7.7% of patients permanently discontinued therapy. At 48-week, all outcomes
showed an improvement compared to baseline. Overall, there was a significant decrease (pvalue≤
0.05) in number and magnitude of symptoms, while HRQoL, satisfaction and adherence
improved significantly. Most patients prefered EVIPLERA® than previous cART. According to the
type of intolerance, HRQoL was improved, but only significantly in patients with neuropsychiatric
and gastrointestinal symptoms. Adherence improved significantly in patients with metabolic
disturbances and satisfaction with EVIPLERA® was higher in the three groups.

Conclusion:
Switching to EVIPLERA® from non-nucleoside reverse-transcriptase-inhibitor or protease
inhibitor-based regimens due to toxicity, improved the presence/magnitude of symptoms,
HRQoL, and preference with treatment. EVIPLERA® maintained a virological response, CD4+ cell
count and maintained or improved adherence.
Potential Role of Regulatory T Cells in Mother-to-Child Transmission of HIV
Authors: Kessler Peter A. 
Published: February 2019

Background:Mother-to-child transmission of HIV-1 occurs in a minority of HIVinfected mother-infant pairs, even without any interventions. The mechanisms that protect the majority of HIV-exposed infants from infection are unclear. T regulatory cells (Treg) have important immunomodulatory functions, but their role in the fetus as well as in mother-to-child transmission of HIV is under-studied.Methods:We studied available cryopreserved peripheral blood mononuclear cells from HIVexposed infants from the Breastfeeding, Antiretrovirals and Nutrition (BAN) Study cohort in Malawi: 64 infants were HIV-uninfected and 28 infants were HIV-infected at birth. We quantified the frequency of Treg cells (CD4+CD25+FoxP3+), and activated CD4+ and CD8+ T cells (CD38+ HLADR+) by flow cytometry at birth, 6 weeks and 6, 9 and 12 months of age. Descriptive statistics were performed to describe the distributions of these lymphocyte markers according to the HIV infection status; and Student’s t tests and Wilcoxon-Rank Sum tests were performed to compare HIVinfected and uninfected infants.Results:T cell activation increased rapidly in the first 6 weeks of life, more pronounced on CD8+ T cells; a further increase in activation was observed at the time of weaning from breastfeeding at 6 months of age. In contrast, the frequency of Treg was stable over the first 6 weeks of life (median, 0.5%), slightly decreased between 6 weeks and 6 months (median at 6 months, 0.3%) and then slightly increased between 6 months (time of weaning) and 12 months of age (median, 0.45%). HIVinfected infants had significantly higher frequencies of activated T cells than uninfected infants (P < 0.01). At the time of birth, HIV-exposed uninfected infants had higher levels of Treg, compared to infants infected in utero, even though this did not reach statistical significance in this small sample size (P = 0.08).Conclusion:This study provides initial evidence that Treg may play a role in preventing mother-tochild transmission of HIV, likely by suppressing immune activation in the fetus and infant, and needs to be substantiated in a larger study. Better characterization of the role of Treg in fetal and neonatal immunity may provide a valuable complementary approach to achieve eradication of mother-to-child transmission of HIV.
Characterization of Chemical Compounds and Antioxidant Activity of Centaurea solstitialis sp. schouwii (DC.) Q. et S. (Asteraceae)
Authors: Aliouche Lamia , Mosset Paul , León Francisco , Brouard Ignacio , Benayache Samir , Sarri Djamel , Benayache Fadila 
Published: February 2019

Background:The antioxidant activity and the total phenolic and flavonoid contents of the derived extracts (chloroform, ethyl acetate and n-butanol) of the 70% hydroalcoholic extract of the aerial parts of Centaurea solstitialis growing in Algeria was assessed. The active extracts were selected for phytochemical investigations.Methods:The antioxidant capabilities of the extracts were assessed using 1, 1-diphenyl-2- picrylhydrazyl radical (DPPH•) scavenging and Cupric Ion Reducing Antioxidant Capacity (CUPRAC) assays. Butylhydroxyanisole (BHA), butylhydroxytoluene (BHT) and α –tocopherol were used as positive controls. The total phenolic content and total flavonoid content of the extracts were determined as gallic acid equivalents and quercetin equivalents, respectively. Chromatographic methods were used to isolate the secondary metabolites and spectrometric and spectroscopic methods were used to determine their chemical structures.Results:The ethyl acetate extract exhibited the highest antioxidant activities followed by the n-butanol extract. The highest phenolic and flavonoid contents were found in the n-butanol extract. Phytochemical study of the ethyl acetate and n-butanol extracts led to the isolation of an undescribed guaianolide named 3-(4-hydroxybenzoyl)-cynaratriol and a known sesquiterpene lactone along with three known flavonoid glycosides. Their structures were established by spectral analyzes mainly high resolution electrospray ionisation mass spectrometry (HR-ESIMS) and 1D and 2D nuclear magnetic resonance experiments.Conclusion:The extracts of aerial parts of C. solstitialis showed significant antioxidant activities. An undescribed sesquiterpene lactone and four known secondary metabolites were isolated from the most active extracts.
Telomere DNA Binding, Cleavage and Anticancer Activity of [Cu(phendione)(Hpyramol)Cl]
Authors: Maheswari Palanisamy Uma , Duraisamy Renuga , Kanagavel Murugesan , Natarajaseenivasan Kalimuthusamy , Meera Sheriffa Begum Kadhar Mohamed , Kandasamy Ruckmani 
Published: February 2019

Background:The ligand Hpyramol is a redox active, which on coordination with Cu(II) cleaves DNA without any added reductant. Another ligand phendione is known for its wide application towards anticancer activities. We combined the ligands with CuCl2 to have an intercalation moiety and a redox active ligand in participation towards telomere DNA cleavage and anticancer activity.Objective:In this study, our aim is to interact it with Human telomere DNA and to see their effects on cancer cells.Methods:The complex [Cu(L)(L’)Cl] has interacted with the human telomere DNA sequence (TTAGGG), HTelo20. The HTelo20 was stabilized under both parallel and antiparallel G-quadruplex conformations and the complex [Cu(L)(L’)Cl] has interacted followed by circular dichroism spectroscopy and gel electrophoresis.Results:The parallel G-quadruplex and randomly coiled conformations of HTelo20 were easily cleaved than the anti-parallel G-quadruplex conformation. The nature of DNA cleavage was found to be oxidative rather hydrolytic. The formation of phenoxyl radical species under electrochemical and controlled potential electrolysis conditions by the complex [Cu(L)(L’)Cl] proves the possibility of oxidative nature of DNA cleavage. The comet assay also proves the DNA cleavage induced by the complex [Cu(L)(L’)Cl] inside the nucleus of HeLa cancer cells.Conclusion:The complex [Cu(L)(L’)Cl] was tested for anticancer activity, induced by ROS and DNA cleavage. The IC50 values resulted in nanomolar concentrations with selected cancer cell lines. Relatively the Cu complex shows less toxicity with the normal cell line L132.
The Real Tools of Magic: Pamphile’s Macabre Paraphernalia (Apuleius, <i>Met.</i> 3,17,4-5)
Authors: Costantini Leonardo 
Published: February 2019

This study aims to shed new light on the references to the materiality of magic in the description of the witch Pamphile’s laboratory at Apul. Met. 3,17,4-5. Through comparing this passage with earlier descriptions of magical paraphernalia in Horace, Lucan, and Petronius and by drawing parallels with non-literary evidence – especially the Papyri Graecae Magicae and the Defixionum Tabellae – it will be shown how Apuleius borrows from the material culture of magic to provide his readership with an exceptionally realistic and gruesome account. Leonardo Costantini is a postdoctoral research fellow at the Albert-Ludwigs-Universität Freiburg, where he is working on a new commentary on Apuleius’ Metamorphoses 3 to complete the GCA series. His research focuses on the literary and textual aspects of Apuleius’ literary works, the ancient novels, writings of the Second Sophistic, taking into account their socio-cultural background with particular attention to Greco-Roman magic. A reworked version of his doctoral dissertation, devoted to Apuleius’ Apologia and magic, is forthcoming at De Gruyter, series: Beiträge zur Altertumskunde.
St. Paul’s Letters and Classical Culture
Authors: Smith Warren S. 
Published: February 2019

Paul in his Letters drew on conventions that would have been familiar to anyone receiving a rudimentary Greek education. The persona used at the end of Romans 1 to denounce the sinners in contemporary culture is based on the alazon or boastful man familiar from satire and the diatribe philosophical style of Bion, Seneca, and later Epictetus. The persona in Romans 7 who prays to be delivered from “this body of death” goes back to Greek tragedy and can be paralleled in the tragic tone of such poets as Ovid and Catullus. The beautiful hymn to love in I Corinthians 13 goes back to Socrates’ speech in Plato’s Symposium and also owes much to the pattern for an encomium used in Aristotle’s Rhetoric and followed by Isocrates and Cicero. Paul’s discussion of “the Married and Unmarried Man” in I Corinthians 7 and “The Weak Man’ in Romans 14 are consistent with stereotypes introduced by Aristotle and Theophrastus and found on stage in comedies such as “The Bad Tempered Man.” All these passages are based on cultural commonplaces that would have made Paul’s arguments come alive to a Greek speaking audience.Warren S. Smith is a retired Professor of Classics at the University of New Mexico. Among his books is Satiric Advice on Women and Marriage from Plautus to Chaucer (Michigan, 2005). His articles on Apuleius and the New Testament have appeared before inAncient Narrative. His church service includes teaching stints in the Philippines and Kenya, and weekly visits to a prison in Los Lunas, N.M.
Digital Games and Mindfulness Apps: Comparison of Effects on Post Work Recovery
Authors: Collins Emily , Cox Anna , Wilcock Caroline , Sethu-Jones Geraint 
Published: February 2019

Background
Engagement in activities that promote the dissipation of work stress is essential for post work recovery and consequently for well-being. Previous research suggests that activities that are immersive, active, and engaging are especially effective at promoting recovery. Therefore, digital games may be able to promote recovery, but little is known about how they compare with other popular mobile activities, such as mindfulness apps that are specifically designed to support well-being.

Objective
The aim of this study was to investigate and compare the effectiveness of a digital game and mindfulness app in promoting post work recovery, first in a laboratory setting and then in a field study.

Methods
Study 1 was a laboratory experiment (n=45) in which participants’ need for recovery was induced by a work task, before undertaking 1 of 3 interventions: a digital game (Block! Hexa Puzzle), a mindfulness app (Headspace), or a nonmedia control with a fidget spinner (a physical toy). Recovery in the form of how energized participants felt (energetic arousal) was compared before and after the intervention and how recovered participants felt (recovery experience) was compared across the conditions. Study 2 was a field study with working professionals (n=20), for which participants either played the digital game or used the mindfulness app once they arrived home after work for a period of 5 working days. Measures of energetic arousal were taken before and after the intervention, and the recovery experience was measured after the intervention along with measures of enjoyment and job strain.

Results
A 3×2 mixed analysis of variance identified that, in study 1, the digital game condition increased energetic arousal (indicative of improved recovery) whereas the other 2 conditions decreased energetic arousal (F2,42=3.76; P=.03). However, there were no differences between the conditions in recovery experience (F2,42=.01; P=.99). In study 2, multilevel model comparisons identified that neither the intervention nor day of the week had a significant main effect on how energized participants felt. However, for those in the digital game condition, daily recovery experience increased during the course of the study, whereas for those in the mindfulness condition, it decreased (F1,18=9.97; P=.01). Follow-up interviews with participants identified 3 core themes: detachment and restoration, fluctuations and differences, and routine and scheduling.

Conclusions
This study suggests that digital games may be effective in promoting post work recovery in laboratory contexts (study 1) and in the real world, although the effect in this case may be cumulative rather than instant (study 2).
Seasonality Patterns of Internet Searches on Mental Health: Exploratory Infodemiology Study
Authors: Soreni Noam , Cameron Duncan H , Streiner David L , Rowa Karen , McCabe Randi E 
Published: February 2019

Background
The study of seasonal patterns of public interest in psychiatric disorders has important theoretical and practical implications for service planning and delivery. The recent explosion of internet searches suggests that mining search databases yields unique information on public interest in mental health disorders, which is a significantly more affordable approach than population health studies.

Objective
This study aimed to investigate seasonal patterns of internet mental health queries in Ontario, Canada.

Methods
Weekly data on health queries in Ontario from Google Trends were downloaded for a 5-year period (2012-2017) for the terms “schizophrenia,” “autism,” “bipolar,” “depression,” “anxiety,” “OCD” (obsessive-compulsive disorder), and “suicide.” Control terms were overall search results for the terms “health” and “how.” Time-series analyses using a continuous wavelet transform were performed to isolate seasonal components in the search volume for each term.

Results
All mental health queries showed significant seasonal patterns with peak periodicity occurring over the winter months and troughs occurring during summer, except for “suicide.” The comparison term “health” also exhibited seasonal periodicity, while the term “how” did not, indicating that general information seeking may not follow a seasonal trend in the way that mental health information seeking does.

Conclusions
Seasonal patterns of internet search volume in a wide range of mental health terms were observed, with the exception of “suicide.” Our study demonstrates that monitoring internet search trends is an affordable, instantaneous, and naturalistic method to sample public interest in large populations and inform health policy planners.
ANALISIS PENGARUH INVESTASI, PDRB, JUMLAH PENDUDUK, PENERIMAAN PEMBANGUNAN, DAN INFLASI TERHADAP PENDAPATAN ASLI DAERAH (PAD) DI KABUPATEN LOMBOK BARAT
Authors: Batik Karlina 
Published: February 2019

Mark sense application autonomousing to expected region gets to give facility to region to even out its own housewifery, also give room opportunity for region to dig up and mendayagunakan is proprietary potency optimal ala. PAD as one of accepting region reflects to increase region independence. The greater PAD therefore points out that region progressively is able to dig up and utilizes source those are at its region. To the effect that wants to be reached in this research is menganalisis affecting investment, PDRB, population, Development acceptance, and inflation to PAD. Observed data in this research is time series's data with runtut time 1980 2007. Estimation model that is utilized is bifilar regression that ditranspormasikan goes to to form logarithm.
Pengaruh Infrastruktur dan Keterkaitan Spasial Terhadap Konvergensi Beta di Indonesia
Authors: Fahmi Anisa 
Published: February 2019

Motivated inter-regional disparities condition that occurs persistently, this thesis examines the Indonesian economy in the long run, whether it will tend to converge or diverge. This convergence is based on the Solow Neoclassical growth theory which assumes the existence of diminishing returns to capital so that when the developed countries reach steady state conditions, developing countries will continuous growth up to ‘catch-up‘ with developed countries. This thesis also focuses on the influence of spatial dependency and infrastructure since regional economics perspective, each region can not be treated as a stand-alone unit. Economical and political situation of a region will influence policy in that region which will also have an impact to the neighboring regions. The estimation results of spatial cross-regressive model using fixed effect method consistently confirmed that the Indonesian economy in the long term will likely converge with a speed of 8.08 percent per year. Other finding is, road infrastructure has a positive effect on economic growth and investment and road infrastructure are spatially showed a positive effect on economic growth. In other words, the investment and the infrastructure of a region not only affect the economic growth of that region but also to the economy of the contiguous region.
ANALISIS PENGARUH SUKU BUNGA KREDIT DAN KRISIS EKONOMI TERHADAP PENANAMAN MODAL DALAM NEGERI DI INDONESIA TAHUN 1990-2010
Authors: Alfarisi Salman 
Published: February 2019

This study aims to determine the development of domestic direct investment (DDI) with lending rates level and to determine the effect of lending rates and economic crisis on domestic direct investment (DDI) in Indonesia in 1990-2010. Based on the result of regression analysis found that the coefficient value of determination (R2) is 0.499. It means the ability of the independent variables consist of lending rates level and economic crisis which is able to explain 49 % of the dependent variable that is domestic direct investment (DDI). From the t test results obtained the level of lending rates have a significant influence on domestic direct investment (DDI) this is proved by t count > t table is amounted to -4.235 > 2.101. On the other hand, the economic crisis has the value t count is 2.432, therefore, the economic crisis also significantly influence the domestic direct investment (DDI). Obtained from the F test that both of lending rates level and economic crisis significantly influence on domestic direct investment (DDI). This is proved by the value of F count (8.972) > F table (3.55).
LAS DISTINTAS OFERTAS DE IDENTIDADES ESTRATÉGICAS EN LOS PAÍSES DE UNASUR Y SU IMPACTO EN LA BÚSQUEDA DE UNA IDENTIDAD DE DEFENSA SURAMERICANA
Authors: Tibiletti Luis 
Published: February 2019

La decisión de los presidentes de la región de promover la construcción de una identidad de defensa suramericana pone nuevamente en debate los temas identitarios tanto a nivel regional como nacional. En este terreno -donde en el pasado eran hegemónicas las visiones esencialistas que consideraban a la identidad como algo nacido de una vez e inmutable-, hoy se le oponen otras visiones incluyendo alguna proveniente de un constructivismo extremo, donde casi no se reconocerían huellas en el pasado y todo depende de quien pueda imponer su “relato”. Por ello en el presente artículo se propugna el paradigma histórico-estructuralista como superación del contrapunto y define a una parte de esa identidad nacional a la que denomina estratégica. Asimismo desarrolla que siempre existen -en ambos niveles nacional y regional-, identidades estratégicas en tensión y que ellas tienen diferentes impactos tanto en el logro de los objetivos asociativos como en el mantenimiento de la larga paz sudamericana.
ADMINISTRATION OF LOADING DOSES OF STATINS FOR PREVENTION OF CONTRAST-INDUCED KIDNEY INJURY DURING ENDOVASCULAR INTERVENTIONS IN PATIENTS WITH ISCHEMIC HEART DISEASE
Authors: Shalaeva O. E. , Vershinina E. O. , Repin A. N. 
Published: February 2019

Percutaneous coronary interventions have become a key method of revascularization in patients with coronary artery disease. Contrast-induced nephropathy is one of the main complications in patients who undergo coronary angiography and percutaneous coronary intervention. Loading doses of statins are often used for the purpose of nephroprotection. However, a clear available algorithm for prescribing statins for the prevention of acute contrast-induced kidney injury has not been identified. The purpose: to evaluate the effectiveness of high loading doses of statins (atorvastatin and rosuvastatin) to prevent acute contrast-induced kidney injury in patients with chronic ischemic heart disease during planned endovascular treatment.Material and Methods. Patients with clinical manifestations of FC II and III angina pectoris and hemodynamically significant stenoses of the coronary arteries were referred for a planned endovascular myocardial revascularization. Two groups of patients were assigned based on the intake of synthetic statins: atorvastatin and rosuvastatin. Before the endovascular intervention, patients were administered with high loading doses of statins. All patients underwent general clinical examination, routine assessment of creatinine levels, other blood tests, assessment of glomerular filtration rate, and control of lipid profile of blood.Conclusion. The incidence rate of contrast-induced kidney injury in patients with coronary artery disease, administered with loading doses of rosuvastatin, in the course of planned percutaneous coronary intervention was lower compared with the loading therapy of atorvastatin: 3.33 and 12.12%, respectively. On average, an increase in creatinine concentration to the maximum level occurred more often in the group of patients administered with a loading dose of atorvastatin than in the other group administered with a loading dose of rosuvastatin (14.3 versus 8.1%, p=0.024). A decrease in renal function in terms of GFR of less than 60 mL/min/1.73 m2 on day 5 was observed in 12 patients (34.3%) in the first group versus 9 patients (27.3%) in the second group. Therapy with loading doses of rosuvastatin before endovascular myocardial revascularization was more effective than treatment of patients with atorvastatin.