bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinan Perilaku Ibu Hamil Terhadap Pemeriksaan Triple Eliminasi (HIV, Sifilis, Hepatitis B) Di Puskesmas Kassi-Kassi Kota Makassar
Authors: Akila Nur , Nur Ulmy Mahmud  , Sartika  
Published: December 2024

Program triple eliminasi merupakan salah satu upaya pemerintah untuk mencegah penyebaran penyakit dari ibu ke bayi. Ketiga penyakit ini memiliki karakteristik yang sama yaitu memiliki cara penyebaran yang sama yaitu melalui hubungan seksual, transfusi selama kehamilan saat bayi dalam kandungan. Pelaksanaan trieliminasi di Indonesia berdasarkan Permenkes No. 52 Tahun 2017 tentang Eliminasi Penularan HIV, Sifilis dan Hepatitis B dari ibu ke anak menjadi satu paket dalam pelayanan antenatal terpadu dengan menetapkan cakupan indikator minimal 95% dari seluruh ibu hamil. Adapun jenis penelitian yang digunakan yaitu kuantitatif menggunakan pendekatan cross sectional, adapun lokasi penelitian ini yaitu Puskesmas Kassi-Kassi Kota Makassar, jumlah populasi 377 ibu hamil dan jumlah sampel 147 responden. Penelitian ini bertujuan untuk mengetahui Perilaku Ibu Hamil Terhadap Pemeriksaan Triple Eliminasi Di Puskesmas Kassi-Kassi Kota Makassar. Dari hasil penelitian diperoleh bahwa Ada hubungan antara tingkat pengetahuan dengan pemeriksaan Triple Eliminasi pada ibu hamil Di Puskesmas Kassi-Kassi Kota Makassar (p value 0,020 < 0,05), ada hubungan antara sikap dengan pemeriksaan Triple Eliminasi pada ibu hamil Di Puskesmas Kassi-Kassi Kota Makassar (p value 0,000 < 0,05), ada hubungan antara Dukungan keluarga dengan pemeriksaan Triple Eliminasi pada ibu hamil Di Puskesmas Kassi-Kassi Kota Makassar (p value 0,000 < 0,05). Diharapkan Pihak puskesmas dapat mempertahankan serta senantiasa memberikan edukasi untuk lebih menambah pengetahuan ibu hamil terkiat peremiksaan Triple Eliminasi. serta ibu hamil diharapkan aktif mencari informasi tentang Triple Eliminasi dan wajib melakukan pemeriksaan Triple Eliminasi dan peneliti selanjutnya dapat menyempurnakan penelitian ini dengan mengembangkan variabel lainnya yaitu peran tenaga kesehatan sebagai askes informasi.
Rancang Bangun Aplikasi Monitoring Dokumen Tagihan Pada PT. Subur Sedaya Maju Berbasis Web
Authors: Andreani Septi , Ariansyah Ariansyah , Barnianto Ahmad 
Published: December 2024

PT. Subur Sedaya Maju Kota Prabumulih adalah perusahaan swasta yang bergerak dibidang penyewa transportasi alat berat yang terletak di Jl. Pipa Pertamina Simpang 4 Kel. Patih Galung, Kec. Prabumulih Barat, Kota Prabumulih. Proses monitoring dokumen tagihan pada perusahaan ini masih menggunakan cara yang manual sehingga dapat mengakibatkan sering terjadinya kesalahan seperti dokumen tagihan yang sulit ditemukan serta mengakibatkan dokumen tagihan hilang. Aplikasi monitoring dokumen tagihan di perusahaan ini sangatlah dibutuhkan karena dalam melakukan penelitian ini yang memiliki tujuan utama yaitu untuk membuat sebuah aplikasi monitoring dokumen tagihan dengan berbasis web untuk mempermudah dalam melakukan pengolahan dokumen tagihan pada perusahaan dengan menggunakan sistem yang sudah terkomputerisasi dengan baik. Perancangan aplikasi ini juga dibuat dengan metode yang digunakan yaitu deskriptif kualitatif serta melakukan pengumpulan data melalui proses pengamatan atau observasi, wawancara dan studi pustaka. Menggunakan data kualitatif yang meliputi data primer serta data sekunder yang dapat digunakan sebagai sumber data. Metode waterfall digunakan untuk pengembangan sistem, dan laporan dicetak dalam format pdf. Hasil dari proses penelitian ini adalah aplikasi berbasis web yang dapat mempermudah dan mengefisienkan monitoring dokumen tagihan di PT. Subur Sedaya Maju Kota Prabumulih, serta agar instansi lain dapat menggunakannya sebagai model referensi ketika mengembangkan sistem yang serupa.
Metabolomic disorders caused by an imbalance in the gut microbiota are associated with central precocious puberty
Authors: Liu Chunjie , Zhou Shasha , Li Yan , Yin Xiaoqin , Li Pin 
Published: December 2024

BackgroundCentral precocious puberty (CPP) is characterized by the premature activation of the hypothalamic-pituitary-gonadal axis, resulting in early onset of sexual development. The incidence of CPP has been rising in recent years, with approximately 90% of cases lacking a clearly identifiable etiology. While an association between precocious puberty and gut microbiota has been observed, the precise causal pathways and underlying mechanisms remain poorly understood. The study aims to investigate the potential mechanisms through which gut microbiota imbalances may contribute to CPP.MethodsIn this study, clinical information and fecal samples were collected from 50 CPP patients and 50 healthy control subjects. The fecal samples were analyzed by 16S rDNA sequencing and UPLC−MS/MS metabolic analysis. Spearman correlation analysis was used to identify the relationships between gut microbiota and metabolites.ResultsThe gut microbiota composition in CPP patients was significantly different from that in healthy controls, characterized by an increased abundance of Faecalibacterium and a decreased abundance of Anaerotruncus. Additionally, significant differences were observed in metabolite composition between the CPP and control groups. A total of 51 differentially expressed metabolites were identified, with 32 showing significant upregulation and 19 showing significant downregulation in the CPP group. Furthermore, Spearman correlation analysis indicated that gut microbiota dysbiosis may contribute to altered metabolic patterns in CPP, given its involvement in the regulation of several metabolic pathways, including phenylalanine and tyrosine biosynthesis and metabolism, the citrate cycle (TCA cycle), glyoxylate and dicarboxylate metabolism, and tryptophan metabolism.ConclusionsThe study revealed the gut microbial and metabolite characteristics of CPP patients by integrating microbiome and metabolomics analyses. Moreover, several key metabolic pathways involved in the onset and progression of CPP were identified, which were regulated by gut microbiota. These findings broaden the current understanding of the complex interactions between gut microbial metabolites and CPP, and provide new insights into the pathogenesis and clinical management of CPP.
Serum osteocalcin levels are inversely associated with UACR in Chinese DKD patients: a meta-analysis of 20 clinical studies
Authors: Hu Xiaolan , Wang Xiyu , Cai Chen , Guo Jiachen , Qian Xin , Yu Jiangyi , Huang Liji , Xie Shaofeng 
Published: December 2024

ObjectiveTo systemically assess the relationship between serum osteocalcin levels and the progression of diabetic kidney disease (DKD) in the Chinese population.MethodsThe PubMed, Web of Science, CNKI, Wanfang Database, VIP and Chinese Medical Journal full-text Database were searched. Two investigators independently reviewed the literature and extracted data based on predetermined inclusion and exclusion criteria. The Newcastle-Ottawa scale was used to assess the quality of the literature. The statistical analysis was performed using Stata16 software.ResultsA total of 20 case-control studies encompassed 4 565 cases, consisting of 643 healthy controls (CN), 1 649 individuals with simple diabetes mellitus (DM), 1 305 with microalbuminuria (MI), and 968 with macroalbuminuria (MA). The meta-analysis results indicated that the serum osteocalcin levels in MI group were significantly lower than those in CN group and DM group [SMD = -1.15, 95% CI (-1.46, -0.85), P &lt; 0.01; and SMD = -0.53, 95% CI (-0.69, -0.37), P &lt; 0.01, respectively], and lower in the MA group compared to the CN group [SMD = -1.28, 95% CI (-1.79, -0.76), P &lt; 0.01]. In the MA group, the serum osteocalcin levels were considerably lower compared to those in DM group and MI group [SMD = -0.93, 95% CI (-1.28, -0.58), P &lt; 0.01; and SMD = -0.41, 95% CI (-0.65, -0.17), P &lt; 0.01, respectively].ConclusionThe serum osteocalcin levels are typically reduced and show a negative correlation with the severity of proteinuria in Chinese patients with DKD. This indicates a decline in bone formation at early-stage in DKD patients, which worsens as the disease progresses.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/,identifier CRD42024580324.
The spatio-temporal evolution of leishmaniasis in the province of Essaouira
Authors: Benkhira Said , Boudebouch Najma , Benazzouz Bouchra 
Published: December 2024

IntroductionLeishmaniasis is a highly prevalent neglected tropical disease. It represents a significant public health concern in northern Africa, particularly in Morocco. To assess the extent of the disease at the provincial level, as well as the temporal evolution of CL cases and their geographic distribution.Methods834 cases of cutaneous leishmaniasis (CL) diagnosed positive by the hygiene and health laboratory of the health delegation of the province of Essaouira during the period from January 1st, 2014 to December 31st, 2023.Results and discussionAmong the 57 communes of the province, three are hyper-endemic and represent the main foci of LC; Elhanchan, Had Draa, Smimou with 66.42% of cases. Other communes with significant increases include Aguerd, with 15.6% of cases, an incidence peak of 279.7 per 100,00.0 in 2022, and Bizdad, 11.8% with an average incidence of 41.1 per 100,000. The transmission of the parasitosis continues to spread to create new outbreaks each year and reach 25 municipalities in the province which have experienced at least one positive case in 2023. Two new outbreaks appeared after 2018 in Sidi Kaouki (5% of cases) and Tidzi (5.6%). The temporal analysis shows a significant rise in cases over time, with an annual average of 83 cases. The trend paused during the COVID-19 lockdown but resumed exponentially, peaking in 2023. The overall incidence in the province increased from 11.1 per 100,000 in 2015 to 40.3 per 100,000 in 2023, with a significant rise over the study period (p &lt; 0.001). The average incidence during this time was 18.32 per 100,000, showing considerable variability across different years.ConclusionThe spread of cutaneous leishmaniasis in the province of Essaouira is multifactorial and results from the complex interaction between vectors, parasites, the environment, and human behaviors. A better understanding of these factors is essential to developing effective disease prevention and controlling strategies.
Assessment of lower urinary tract symptoms 6 weeks after delivery and the relationship of pelvic floor muscle function
Authors: Zhang Lei , Wang Xiaoxiao , Hou Xinnan , Zhuang Xinrong , Wang Yu , Wang Xiaoqing , Lu Ye 
Published: December 2024

BackgroundStudies on lower urinary tract symptoms (LUTS) in women, especially in relation to different modes of delivery, are limited. The relationship between the emergence of LUTS and the decline of pelvic muscle function after childbirth remains uncertain.Study designThis observational study was carried out at the Peking University First Hospital over a time span of 2019–2022. A total of 2,462 women were recruited and surveyed 6 weeks after delivery, utilizing questionnaires for data collection. Additionally, gynecological physical examinations and pelvic floor muscle screenings were conducted as part of the study. To assess individual LUTS and the level of discomfort caused by these symptoms, a modified Chinese version of the Bristol Female Lower Urinary Tract Symptoms questionnaire was employed. Data analysis methods such as descriptive statistics, χ2 tests, one-way ANOVAs, and multivariate logistic regressions were used to thoroughly examine the collected data.ResultsA high prevalence of LUTS was observed in the study participants, with 70.6% experiencing any symptoms. Storage symptoms were reported by 65.4%, while voiding symptoms were reported by 23.0%. Nocturia was the most commonly reported symptom (35.4%), followed by frequency (25.6%) and urgency (25.3%). Stress urinary incontinence (SUI) was reported by 20.8% of women. Interestingly, nocturia and frequency were generally perceived as less troublesome, with only a minority rating them as problematic. In contrast, urinary incontinence (UI) was frequently reported as highly bothersome, with SUI and urge urinary incontinence (UUI) accounting for significant proportions. Vaginal delivery (VD) and forceps delivery (FD) were identified as significant predictors of LUTS, with statistical significance observed (P &lt; 0.05). Specifically, women who underwent VD, particularly FD, exhibited lower surface electromyography (sEMG) activity compared to those who had cesarean section (CS), both in terms of resting baseline and contraction amplitude (P &lt; 0.001).ConclusionsOver half of the examined women exhibited LUTS 6 weeks postpartum, with the most common symptoms being nocturia, frequency, urgency, and SUI. Straining and urinary incontinence were commonly reported as significantly uncomfortable, particularly severe in cases of UI. Additionally, vaginal delivery methods, especially those involving the use of forceps (FD), seemed to be more likely to cause pelvic floor muscle or nerve damage, making it the key predictor of storage-related LUTS.
Quantifying conformational changes in the TCR:pMHC-I binding interface
Authors: McMaster Benjamin , Thorpe Christopher J. , Rossjohn Jamie , Deane Charlotte M. , Koohy Hashem 
Published: December 2024

BackgroundT cells form one of the key pillars of adaptive immunity. Using their surface bound T cell antigen receptors (TCRs), these cells screen millions of antigens presented by major histocompatibility complex (MHC) or MHC-like molecules. In other protein families, the dynamics of protein-protein interactions have important implications for protein function. Case studies of TCR:class I peptide-MHCs (pMHC-Is) structures have reported mixed results on whether the binding interfaces undergo conformational change during engagement and no robust statistical quantification has been done to generalise these results. Thus, it remains an open question of whether movement occurs in the binding interface that enables the recognition and activation of T cells.MethodsIn this work, we quantify the conformational changes in the TCR:pMHC-I binding interface by creating a dataset of 391 structures, comprising 22 TCRs, 19 MHC alleles, and 79 peptide structures in both unbound (apo) and bound (holo) conformations.ResultsIn support of some case studies, we demonstrate that all complementarity determining region (CDR) loops move to a certain extent but only CDR3α and CDR3β loops modify their shape when binding pMHC-Is. We also map the contacts between TCRs and pMHC-Is, generating a novel fingerprint of TCRs on MHC molecules and show that the CDR3α tends to bind the N-terminus of the peptide and the CDR3β tends to bind the C-terminus of the peptide. Finally, we show that the presented peptides can undergo conformational changes when engaged by TCRs, as has been reported in past literature, but novelly show these changes depend on how the peptides are anchored in the MHC binding groove.ConclusionsOur work has implications in understanding the behaviour of TCR:pMHC-I interactions and providing insights that can be used for modelling Tcell antigen specificity, an ongoing grand challenge in immunology.
Effects of L-carnitine supplementation on lipid profile in adult patients under hemodialysis: a systematic review and meta-analysis of RCTs
Authors: Karimi Mehdi , Pirzad Samira , Pourfaraji Seyed Morteza Ali , Parhizkar Roudsari Peyvand , Shirsalimi Niyousha , Ahmadizad Sajad 
Published: December 2024

BackgroundChronic kidney disease (CKD) affects 10% of the global population and leads to end-stage renal disease (ESRD). Hemodialysis is a common treatment for ESRD, but patients often have low carnitine levels, leading to dyslipidemia, a risk factor for cardiovascular disease and the leading cause of mortality. This study aimed to assess the effects of L-carnitine on lipid profiles in adult hemodialysis patients.MethodsA comprehensive search was conducted across the online databases from inception to June 2024 to identify randomized clinical trials (RCTs) evaluating the effects of L-carnitine on lipid profiles in hemodialysis patients. Data extraction and quality assessment were performed, focusing on primary outcomes, including changes in triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL), and secondary outcomes including blood pressure (BP) and body mass index (BMI).ResultsA total of 28 RCTs were eligible for the current systematic review, including 1,340 hemodialysis patients (671 intervention, 669 control). There were no significant differences in the mean change of TG (SMD: −0.006; 95% CI, −0.272 to 0.259; P = 0.95), TC (SMD: −0.086; 95% CI, −0.253 to −0.079; P = 0.29), HDL (SMD: 0.060; 95% CI, −0.057 to 0.177; P = 0.29), LDL (SMD: −0.075; 95% CI, −0.274 to 0.123; P = 0.43), VLDL (SMD: −0.064; 95% CI, −0.272 to 0.142; P = 0.51), BMI (SMD: −0.025; 95% CI, −0.139 to 0.088; P = 0.56), systolic BP (SMD: 0.055; 95% CI, −0.110 to 0.220; P = 0.43), and diastolic BP (SMD: −0.028; 95% CI, 0.156 to 0.099; P = 0.56). The same insignificant findings were observed after conducting a subgroup analysis based on the route of administration (intravenous vs. Oral).ConclusionL-carnitine supplementation does not significantly change and improve the serum lipid profile, including TG, TC, HDL, LDL, and VLDL levels. Additionally, it has no notable effects on BMI, systolic, or diastolic BP.
Effects of suspension exercise training in the treatment of lumbar disk herniation: a systematic review and meta-analysis
Authors: Liu Yu’ang , Huang Silang , Zhang Xinxin , Liao Huangying , Liu Weiguo , Zhang Zhi 
Published: December 2024

ObjectiveThe study aimed to systematically evaluate the efficacy of suspension exercise training (SET) in the treatment of lumbar intervertebral disk herniation and provide a scientific basis for clinical treatment.MethodsDatabases such as CNKI, Chinese Wanfang, PubMed, Cochrane, the Web of Science, and Embase were searched up to June 2024. A quality assessment was performed using the Cochrane Collaboration’s risk-of-bias guidelines, and a meta-analysis was conducted using RevMan 5.4 and Stata 17.0.ResultsA total of 11 studies involving 943 patients were included. Suspension exercise training significantly improved the lumbar disk herniation (LDH) visual analog scale (VAS) score (mean difference (MD) = −0.96; 95% confidence interval (CI), −1.10 to-0.82; p &lt; 0.00001, I2 = 23%), the Japanese Orthopedic Association (JOA) score (MD = 3.29, 95% CI, 1.67 to 4.90; p &lt; 0.0001, I2 = 92%), and the Oswestry Disability Index (ODI) score (MD = −5.41, 95% CI, −7.41 to −3.40; p &lt; 0.00001, I2 = 86%). Subgroup analysis of the JOA score showed better efficacy with suspension exercise training combined with traditional Chinese medicine (TCM) (MD = 4.29, 95% CI, 2.73 to 5.86; p &lt; 0.00001, I2 = 80%) compared to suspension exercise training combined with non-TCM (MD = 0.96, 95% CI, 0.49 to 1.43; p &lt; 0.0001, I2 = 0%).ConclusionSuspension exercise training significantly improved the VAS score, JOA score, and ODI score of the patients with lumbar disk herniation; however, there was a high degree of heterogeneity in the JOA score and ODI score. Further validation is needed in the future for different populations with lumbar disk herniation, the specific locations of its occurrence, and the combined modality of suspension exercise training.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024554074.
The impact of coffee consumption on osteoarthritis: insights from NHANES and Mendelian randomization analysis
Authors: Feng Kai , Li Peng , Guo Haohui , Chen Zhirong 
Published: December 2024

BackgroundOsteoarthritis (OA) is a prevalent degenerative joint condition, and emerging evidence suggests that dietary factors, such as coffee consumption, may influence its risk. However, the relationship between coffee consumption and the risk of developing OA remains ambiguous. This study aims to explore the association between coffee intake and OA complemented by Mendelian randomization (MR) to infer causality.Materials and methodsWe analyzed data from 32,439 participants across 10 NHANES cycles (1999–2018), including 3,676 individuals diagnosed with OA. Osteoarthritis was diagnosed through a structured questionnaire, while coffee consumption was assessed via 24-h dietary recalls. Participants were categorized based on reported coffee intake: 0 cups, &lt;2 cups, 2–4 cups, and &gt;4 cups per day. We employed weighted multivariable logistic regression to examine associations between coffee consumption and OA by using data from the NHANES 1999–2018, adjusting for various covariates. Subsequently, a MR analysis was conducted using genetic variants as instrumental variables to infer causal relationships, with multiple methods including inverse-variance weighted (IVW) analysis, MR-Egger regression, and weighted median techniques to assess the robustness, heterogeneity, and potential pleiotropy of our findings.ResultsOur regression models indicated an increased risk of OA with rising coffee consumption, with significant associations noted particularly for those consuming more than 4 cups daily (OR = 1.19, 95% CI: 1.00–1.41, p = 0.049). In MR analysis, coffee intake was causally linked to OA types, demonstrating increased risk for knee OA (KOA: OR = 1.60, 95% CI: 1.08–2.35, p = 0.018), hip OA (HOA: OR = 1.85, 95% CI: 1.06–3.25, p = 0.031), and combined KOA and HOA (KHOA: OR = 1.66, 95% CI: 1.18–2.33, p = 0.003). Sensitivity analyses confirmed the stability of results across multiple evaluation methods.ConclusionOur findings highlight a significant association between coffee consumption and an increased risk of OA, suggesting that higher intake levels may contribute to OA morbidity. These results warrant further exploration into the underlying biological mechanisms and implications for dietary guidelines in populations at risk for OA.