bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Scanning Electron Microscope (SEM) Mikroarsitektur Daerah Metafisis Os Femur Tikus Putih (Rattus novergicus) Ovariohisterektomi dengan Pemberian Madu Lebah (Apis dorsata) Hutan Sumbawa
Authors: Yordan Samsi , Hasib Abdullah , Ibrahim Muhammad Huda Ramadhan , Rohmah Siti Nur , Abani Salsabilla , Yudaniayanti Ira Sari 
Published: October 2018

The aims of this study to determine the effect of honey bees (Apis dorsata) to prevent the decrease of femur density in ovariohysterctomized rats as animal model of osteoporosis by Scanning Electron Microscope (SEM). This study used 20 adult female white rats (Rattus norvegicus) with body weight 300 gr. Divided into 5 groups, negative control group (P0-), not in ovariohysterectomy, only given aquadest 1.5 ml/day ; Positive control group (P0 +), in ovariohysterectomy, only given aquadest 1.5 ml/day; Treatment group 1 (P1), in ovariohysterectomy and given honey 1 gram / kg BB + 1.5 ml aquadest; Treatment group 2 (P2), in ovariohysterectomy and given honey 2 grams / kg BB + 1.5 ml aquadest; Treatment group 3 (P3), in ovariohysterectomy and given honey 4 grams / kg BB + 1.5 ml aquadest. After 12 weeks, all rats were sacrified for removal of the femur and performed by SEM. Analysis of SEM showed that mice administered honey with a dose of 4 grams / kg BW (P3) showed bone density approaching negative control treatment (P0-), ie, ovariohysterectomized rats. P3 showed the most less bone porosity than other treatment groups. The largest and most uniformly distributed porosity was shown by the positive control group (P0 +). The best results with the smallest quantity and size of the porosity of femur is in P3 group. In conclusion, honey (Apis dorsata) can prevent the decrease in bone density of the femur by Scanning Electron Microscope (SEM).
Procurement Biopsies in the Evaluation of Deceased Donor Kidneys
Authors: Carpenter Dustin , Husain S. Ali , Brennan Corey , Batal Ibrahim , Hall Isaac E. , Santoriello Dominick , Rosen Raphael , Crew R. John , Campenot Eric , Dube Geoffrey K. , Radhakrishnan Jai , Stokes M. Barry , Sandoval P. Rodrigo , D’Agati Vivette , Cohen David J. , Ratner Lloyd E. , Markowitz Glen , Mohan Sumit 
Published: October 2018

Background and objectives
Biopsies taken at deceased donor kidney procurement continue to be cited as a leading reason for discard; however, the reproducibility and prognostic capability of these biopsies are controversial.

Design, setting, participants, & measurements
We compiled a retrospective, single-institution, continuous cohort of deceased donor kidney transplants performed from 2006 to 2009. Procurement biopsy information—percentage of glomerulosclerosis, interstitial fibrosis/tubular atrophy, and vascular disease—was obtained from the national transplant database. Using univariable, multivariable, and time-to-event analyses for death-censored graft survival, we compared procurement frozen section biopsy reports with reperfusion paraffin-embedded biopsies read by trained kidney pathologists (n=270). We also examined agreement for sequential procurement biopsies performed on the same kidney (n=116 kidneys).

Results
For kidneys on which more than one procurement biopsy was performed (n=116), category agreement was found in only 64% of cases (κ=0.14). For all kidneys (n=270), correlation between procurement and reperfusion biopsies was poor: overall, biopsies were classified into the same category (optimal versus suboptimal) in only 64% of cases (κ=0.25). This discrepancy was most pronounced when categorizing percentage of glomerulosclerosis, which had 63% agreement (κ=0.15). Interstitial fibrosis/tubular atrophy and vascular disease had agreement rates of 82% (κ=0.13) and 80% (κ=0.15), respectively. Ninety-eight (36%) recipients died, and 56 (21%) allografts failed by the end of follow-up. Reperfusion biopsies were more prognostic than procurement biopsies (hazard ratio for graft failure, 2.02; 95% confidence interval, 1.09 to 3.74 versus hazard ratio for graft failure, 1.30; 95% confidence interval, 0.61 to 2.76), with procurement biopsies not significantly associated with graft failure.

Conclusions
We found that procurement biopsies are poorly reproducible, do not correlate well with paraffin-embedded reperfusion biopsies, and are not significantly associated with transplant outcomes.
Budget impact analysis of ocriplasmin for the treatment of symptomatic vitreomacular adhesion in the USA
Authors: Yu Tiffany M , Dugel Pravin U , Haller Julia A , Kaiser Peter K , Arnold Renée JG 
Published: October 2018

Background:
Vitreomacular traction (VMT) treatment options include watchful waiting, vitrectomy and intravitreal ocriplasmin injection (Jetrea
®
). This analysis used results from the recently completed OASIS randomized clinical trial to evaluate the 2-year budget impact of ocriplasmin injection availability for treatment of Stage I or II VMT without epiretinal membrane formation in a modeled US health plan.
Materials & methods:
VMT prevalence, treatment patterns and disease resolution rates were from literature, a US retinal-specialist survey and the OASIS trial. Medicare payment rates were applied and a national scenario analysis was conducted.
Results:
With ocriplasmin available, vitrectomy use and complications-related costs decreased. Budget impact of ocriplasmin to the health plan was US$143,599 over 2 years or US$0.0060 per-member per-month.
Conclusion:
Ocriplasmin was projected to be minimally cost-additive at US$0.0060 per-member per-month over 2 years.
Perbedaan Kadar Brain Derived Neurotropic Factor Neonatus Dari Ibu Hamil Normal Dan Anemia Defisiensi Besi
Authors: Mardiah Ainal , Amir Arni , Friadi Andi , Nasrul Ellyza 
Published: October 2018

<p><em>Iron deficiency anemia is anemia caused by iron deficiency in the blood. Maternal iron deficiency affects the low iron reserves in neonates </em><em>and it also influences on </em><em>Brain Derived Neurotropic Factor (BDNF) </em><em> which affects cognitive function.</em><em> </em><em>The purpose of this study was to determine the difference mean of BDNF in neonates from normal pregnant women and pregnant women with iron deficiency. </em><em>The design of this research was Cross Sectional</em><em> </em><em>design. This research was conducted in Community Health Center of Lubuk Buaya, Ambacang Community Health Center, Community Health Center of Ikur Koto Health Center and Biomedical Laboratory of Andalas University on February 2017 to April 2018. There were 42 pregnant women was selected as sample e of this research. The samples were chosen by Consecutive Sampling. Then, the sample is divided into two groups: normal pregnant women and pregnant women with iron deficiency anemia. BDNF are examined by the ELISA. Next, the data were analyzed by using T test. The levels of BDNF neonates in normal pregnant group was 3.65(ng/ml) and the anemia pregnant group was 1.74(ng/ml) (p &lt;0.05). There was significant difference of BDNF levels in neonates from normal pregnant women and pregnant women with iron deficiency anemia. </em><em>The conclusion of this study is there is a difference of average BDNF in neonates from normal pregnant women and pregnant women with iron deficiency.</em></p><p> </p><p>Anemia defisiensi besi adalah anemia yang disebabkan karena kekurangan zat besi dalam darah. Defisiensi besi maternal berdampak pada rendahnya cadangan besi pada neonatus dan berdampak terhadap ekspresi Brain Derived Neurotropic Factor (BDNF) yang berpengaruh pada fungsi kognitif. Tujuan penelitian ini adalah untuk mengetahui perbedaan rerata kadar BDNF pada neonatus dari ibu hamil normal dan ibu hamil defisiensi besi. Desain penelitian ini adalah Cross Sectional. Penelitian dilakukan di Puskesmas Lubuk Buaya, Puskesmas Ambacang, Puskesmas Ikur Koto dan Laboratorium Biomedik Universitas Andalas pada bulan Februari 2017 – Juli 2018. Sampel Penelitian adalah ibu hamil sebanyak 42 orang yang dipilih secara Consecutive Sampling, sampel dibagi menjadi dua kelompok yaitu ibu hamil normal dan ibu hamil anemia defisiensi besi. BDNF diperiksa dengan metode ELISA. Data dianalisa menggunakan uji T test. Kadar BDNF neonatus pada ibu kelompok normal adalah 3,65(ng/ml) dan kelompok ibu anemia adalah 1,74(ng/ml) (p&lt;0,05). Terdapat perbedaan bermakna kadar BDNF pada neonatus dari ibu hamil normal dan ibu anemia defisiensi besi. <em></em></p>
Marxismo e geografia(A Geograficidade e o diálogo das Ontologias)
Authors: Moreira Ruy 
Published: October 2018

Os dois momentos em que marxismo e geografia se cruzaram numa reciprocidade de influências, o peso do diálogo foi dado à teoria do conhecimento. O atual momento prioriza a reflexão das ontologias. Abstract:During two moments of intercrossing between Marxism and Geography, reciprocally influenced, the stressing was to the knowledge theory. Nowadays we put emphasis on the reflection about ontologies.
Centros históricos- Mercantilização e territorialidades do patrimônio cultural urbano
Authors: Paes-luchiari Maria Tereza D. 
Published: October 2018

Este artigo trás à reflexão os processos sócio-espaciais envolvidos nos atuais projetos de refuncionalização urbana, destacando as estratégias de preservação do patrimônio histórico edificado e de reintegração de áreas urbanas abandonadas, sobretudo nos Centros Históricos consolidados pela industrialização. O gerenciamento político e empresarial dessas áreas tem subvertido o caráter público desses bens e fortalecido a imagem das cidades como mercadorias vendáveis no mercado global.AbstractThis paper aims to contribute to the reflection of the socio-spatial processes involved in the current projects of urban refuntionalization, enhancing the strategies for preservation of the built historical patrimony and the reintegration of the abandoned urban areas, mainly in the histoncal centers consolidated by industries. The political and business management have subverted the public character of these goods, and strength the image of cities as goods to be sold in the global market.
Campesinidade e território Quilombola no norte do Espírito Santo
Authors: Batista Ferreira Simone Raquel 
Published: October 2018

Este trabalho busca analisar as comunidades negras rurais do norte do Espírito Santo a partir das características e práticas camponesas na reapropriação de seu território. Estas práticas de territorialidade retomam antigas origens e saberes, e vêm sendo fortalecidaspela incorporação do direito étnico ao território, ora afirmado pelo Estado por meio de seureconhecimento como "comunidades remanescentes de quilombos". Abstract This work aims to analyse the rural black communities of north Espírito Santo state, in Brazil, from the peasants characteristics and practices in the reappropriation of their territov. These practices of territoriality retake old origins and wisdoms, and they are being stressed through the incorporation of ethnic rights to tenitory, at the same time legitimated by the State through its recognition as "communities remaining of quilombos".
Novos contornos do crescimento urbano brasileiro? O conceito de Urban Sprawl e os desafios para o Planejamento Regional e Ambiental
Authors: Ojima Ricardo 
Published: October 2018

Resumo: A transição para um mundo predominantemente urbano, segundo as estimativas da ONU, nos coloca frente a novos desafios para entender os processos sociais e espaciais que se configuram nas aglomerações urbanasbrasileiras. Portanto, a incorporação de abordagens que incluam a dinâmicaregional e espacial é fundamental para ampliar o escopo dos estudosurbanos. A partir deste trabalho, resgatamos a abordagem do urban sprawlda literatura norte-americana no objetivo de entender quais são as suascontribuições para o caso brasileiro, colocando um novo conjunto dequestões onde a preocupação com as mudanças ambientais se torna cadavez mais presente na vida cotidiana. ARE THERE NEW OUTLINES OF THE BRAZILIAN URBAN GROWTH? THE URBAN SPRAWL CONCEPT AND THE CHALLENGES FOR THE REGIONAL AND ENVIRONMENTAL PLANNINGAbstract: The transition for a predominantly urban world, accordingly UNestimative, put us into new challenges to understand the social and spatialprocesses that are being configured in Brazilian urban agglomerations.Therefore, incorporating approaches that include regional and spatialdynamics is fundamental to extend the urban studies field. Through thispaper we review the approach of urban sprawl from the US literature tounderstand which are its main contributions to the Brazilian case,presenting a new group of questions where the concern with environmentalchange become much more present in everyday life.Key words: Urbanization; Urban Sprawl; Environmen
PERCEPÇOES DE AGENTES DE SAÚDE E PROFESSORES DE UMA REGIÃO SEMIÁRIDA SOBRE BACTÉRIAS E DOENÇAS DE VEICULAÇÃO HÍDRICA
Authors: Florêncio de Araújo Magnólia Fernandes , Felix do Nascimento Viviane Silva 
Published: October 2018

A qualidade da água vem sendo diminuída, situação que contribui para o aumento da incidência de doenças de veiculação hídrica. Sabendo-se que os problemas ambientais provocam também problemas de ordem social, faz-se necessário a realização de medidas educativas com o objetivo de informar e sensibilizar a população. O objetivo desse trabalho foi investigar as concepções de professores e agentes de saúde de dois municípios do nordeste brasileiro a respeito dos temas “doenças de veiculação hídrica” e “bactérias”. Os resultados revelam que alguns dos participantes possuem concepções equivocadas sobre os temas tratados, havendo assim a necessidade de implementação de atividades educativas a respeito dos temas abordados, tanto com os professores como com os agentes de saúde.
PENGARUH KESADARAN SITUASI IBU HAMIL DENGAN FREKUENSI KUNJUNGAN ANTENATAL DI WILAYAH KERJA PUSKESMAS WARU KABUPATEN PAMEKASAN TAHUN 2016
Authors: Uktutias Sendy Ayu Mitra , Pratiwi Niniek Lely , Purnomo Windhu 
Published: October 2018

Basic Health Research Results (Riskesdas) conducted by the Ministry of Health shows that the coverage of K4 during the last 3 years in 2010–2013 is the year 2010 by 86.85% and the year 2013 of 87.48%. The lack of utilization of ANC by pregnant women is associated with many factors, one of which is the lack of awareness of pregnant women about the importance of pregnancy care. The purpose of this study analyzed the influence of awareness of the situation of pregnant women with the frequency of antenatal visits. The research method was analytic observational with cross sectional study design. The study sample was 38 pregnant women who lived in the working are at waru public health center’s. The sampling technique using simple random sampling. Data collection using primary data by questionnaire and secondary data with the instrument KIA book. Data were processed and analyzed by using frequency distribution and inferential analyze of linier regression with a significance level of 5% (p = 0.05). The results of linear regression analysis in pregnant women showed significant value of β 0.684 (β > 0.500), that the awareness of the situation had an effect on the frequency of antenatal care. A good situation awareness is a necessary process to influence the decision to act, it is a pregnancy test and can be seen the frequency of antenatal care of a pregnant woman. This conclusion Waru public health center’s is a health clinic located in the highlands. Still less maximal antenatal care visits because of the support and access to antenatal care. It is suggested to raise awareness of pregnant women situation through family involvement, husband as reinforcement factor in support of improvement of antenatal care examination.
Family Office: Instrumento de gestión del patrimonio familiar
Authors: Rivo-López Elena , González-Vázquez Beatriz , Rodríguez-López Nuria 
Published: October 2018

En este trabajo nos aproximamos al concepto de Family Office, considerándola como un instrumento más que puede utilizar la familia empresaria para gestionar y diversificar sus activos y riesgos. Tras un análisis teórico sobre el concepto, sus distintas modalidades y sus diferentes formas de implantación en las empresas, con este trabajo se trata de profundizar en las diferentes estrategias que se pueden seguir con objetivos diferentes según la modalidad de “family office” implementada, así como identificar las características diferenciadoras entre las diversas estructuras existentes.
El concepto tradicional de family office (FO) se centra en un negocio dirigido por y para una sola familia. Su principal función consiste en centralizar la gestión de un patrimonio familiar significativo. El objetivo es la transferencia del patrimonio entre generaciones.
La estructura de la FO refleja los valores y principios de la familia propietaria, que a su vez marcarán los objetivos perseguidos por la misma, y las actividades necesarias para alcanzarlos. El tamaño de estas organizaciones dependerá de si las actividades realizadas son llevadas a cabo con personal interno o externo, observándose una clara tendencia hacia la externalización.
En España se podrían identificar tres tipos de family office, en función básicamente de las actividades realizadas: servicios, servicios e inversión, o exclusivamente inversión.
In this paper we approach the concept of Family Office, as a tool available to the members of family business to manage and diversify their assets and risks. First, the research makes a theoretical analysis of the concept, the different modalities and different ways of implementing a family office . Then, this study analyzes the different strategies that can be taken with different purposes (depending on the type of family office implemented), and the differential characteristics between the several structures.
The traditional concept of family office (FO) focuses on a business run by and for one family. Its function is to centralize the management of a significant family fortune. Typically, these organizations employ staff to manage investments, taxes, philanthropy, trusts and legal services. The aim is to transfer wealth between generations.
The Family Office structure reflects the values and principles of family owners, these values will determine the objectives, and activities needed to achieve them. The size of these organizations depend on whether the activities are carried out in-house or outsourced, showing a clear trend towards outsourcing.
In Spain, we could identify three types of family office. First, that family office that provides services exclusively to shareholders members of the family business. Another kind of family office also provides these services to family members, investing in venture capital or development capital. A third modality is a family office that conforms an Investment Conference, whether in venture capital, development capital, ...
Farklı Maserasyon Koşullarının Öküzgözü Şaraplarının Fenolik Bileşiklerine Etkisi
Authors: BAYRAM Mustafa 
Published: October 2018

Bu çalışmada, 2009 ve 2010 yılllarında hasat edilen
Öküzgözü üzüm çeşidinden 4 farklı maserasyon (klasik maserasyon, enzim ilaveli
klasik maserasyon, soğuk uygulamalı maserasyon, enzim ilaveli soğuk maserasyon)
uygulamasıyla elde edilen şarapların çeşitli kimyasal özellikleri, toplam
fenolik madde içeriği, toplam antosiyanin içeriği, bazı bireysel fenolik ve
antosiyanin bileşikleri belirlenmiştir. Elde edilen bulgulara göre, en yüksek
toplam fenolik madde içeriği 2009 ve 2010 yıllarında sırasıyla “enzim ilaveli
soğuk maserasyon” (1165.45 mg gallik asit eşdeğeri (GAE)/L) ve “enzim ilaveli
klasik maserasyon” (2075.91 mg GAE/L) şaraplarında belirlenmiştir. Öküzgözü
şaraplarında en yüksek toplam antosiyanin içeriği 2009 ve 2010 yıllarında
sırasıyla “enzim ilaveli soğuk maserasyon” (140.60 mg malvidin-3-O-glikozit
eşdeğeri (ME)/L), “soğuk maserasyon” (374.89 mg ME/L) örneklerinde saptanmıştır. "Soğuk
maserasyon” ve “enzim uygulamalı soğuk maserasyon” proseslerinin her iki yıl
şarapları için genel olarak yüksek malvidin 3-glikozit içeriği verdiği belirlenmiştir.
Şıra ve şaraplarda en yüksek oranda bulunan&nbsp;
fenolik bileşik flavanoller grubuna dahil olan (+)-kateşindir. Şaraplarda,
(+)-kateşinden sonra en fazla bulunan fenolik bileşikler sırasıyla gallik asit
ve (-)-epikateşin olarak belirlenmiştir.
Incidental Aluminum Phosphide Poisoning: Case Report and Current Management
Authors: Çakın Özlem , Tazegul Gokhan , Gümüş Ayça , Cengiz Melike , Ramazanoğlu Atilla 
Published: October 2018

Abstract
Aluminum phosphide (AlP) is a commonly used cheap rodenticide, insecticide, and fumigant. Most intoxications in the literature are suicidal ingestions, however, AlP may cause incidental inhalational toxicities as well. After ingestion or inhalation, nausea, vomiting, dyspnea and abdominal pain develops within minutes. Hallmark of toxicity is refractory hypotension, cardiac failure and severe metabolic acidosis developing within a matter of hours are the major cause of mortality. In Turkey, AlP tablets are widely accessible and are sold without any restrictions. However, there are few local case reports in the literature. Additionally, incidental AlP intoxications are rarely reported.
Herein, we present a 25-year-old male patient incidentally poisoned with AlP. He was found unconscious in a grain storage unit protected by aluminum phosphide tablets. He had hypotension and tachycardia. Arterial blood gas analysis did not reveal metabolic acidosis. He was quickly intubated and admitted to Intensive Care Unit (ICU). Supportive care crystalloid solution, n-acetyl cysteine and norepinephrine infusion was administered. After 36 hours, he was extubated and discharged without any complications.
There is no specific antidote or treatment for AlP toxicity. Literature is controversial regarding treatment approach. Inhalational toxicity may occur under extreme conditions, as presented in this case report. Preventive strategies should be considered to reduce incidents. Clinicians should also be aware that AlP is a widely available and highly toxic compound that has no specific antidote and toxicity needs to be urgently treated with best supportive care.