bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KELAYAKAN PEMBERIAN KREDIT PADA BTM RENGAT KABUPATEN INDRAGIRI HULU
Authors: Astarman Astarman 
Published: April 2019

Penelitian ini dilaksanakan pada BTM Rengat Kabupaten Indragiri Hulu. Perumusan masalah adalah bagaimana Kelayakan Pemberian Kredit pada BTM Rengat Kab. Indragiri Hulu. Tujuan penelitian adalah untuk mengetahui dan menganalisis kelayakan pemberian kredit pada BTM Rengat Kabupaten Indragiri Hulu.
Data dan informasi yang digunakan dalam penelitian ini dihimpun dengan cara penelitian lapangan dan pengamatan. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis deskriptif dengan menganalisis kelayakan pemberian kredit menggunakan Prinsip 6C, menganalisis kelayakan pemberian kredit usaha mikro dan menganalisis kredit bermasalah dari kredit pada BTM Rengat selama 5 tahun terakhir.
Hasil penlitian dapat disimpulkan bahwa berdasarkan hasil analisis prinsip 7C untuk menguji kelayakan pemberian kredit pada BTM Rengat diantaranya: penilaian aspek: character, capacity, capital, collateral, conditions of economy, constraint telah dilaksanakan oleh BTM Rengat dengan baik dan sesuai dengan SOP yang dimiliki BTM Rengat. Dari hasil analisis kelayakan pemberian kredit pada BTM Rengat menggunakan Prinsip 3R, BTM Rengat telah melaksanakan aspek Return, Repayment Capacity, dan Risk Bearing Ability sebagai penilaian pemberian kredit kepada calon debitur, ini berguna untuk mengurangi risiko kredit macet dikemudian hari. Persentase NPL pada BTM Rengat dari tahun 2013 s/d 2017 masuk dalam kategori sangat baik. Hal ini dinilai sangat baik karena NPL dari tahun ke tahun semakin mendekati 0% dan masih berada dalam batas kewajaran yaitu di bawah 5% sesuai dengan Peraturan yang ditetapkan BI
PENGARUH BIAYA TERHADAP LABA PADA STIE-I MART RENGAT KABUPATEN INDRAGIRI HULU
Authors: Hapsila Angga 
Published: April 2019

Penelitian ini dilakukan oleh penulis pada minimarket STIE-I Mart yang beralamat di Jl. R. Soeprapto Rengat Kabupaten Indragiri Hulu. Pelaksanaan penelitian berlangsung selama 3 (Tiga) bulan terhitung bulan juni 2017 sampai dengan agustus 2017. Dilakukannya penelitian ini adalah untuk mengetahui pengaruh biaya terhadap laba pada STIE-I Mart Rengat Kabupaten Indragiri Hulu.
Penelitian ini menggunakan data primer, penulis melakukan pengolahan data dengan menggunakan regresi linear sederhana dengan rumus y = a + bx, lalu mengolahnya dengan menggunakan SPSS (statistic package for social scince) versi 24 untuk mendapatkan output guna menyimpulkan hasil penelitian ini.
Dari hasil penelitian dapat ditarik kesimpulan yaitu nilai a sebesar -1256705,700 dan nilai b adalah 0.074, dan persamaan regresi linear menjadi : y = -1256705,700 + 0,074x. Dan ini dapat diartikan Jika besarnya biaya (x) konstan atau 0 (nol) maka besarnya nilai laba (y) sebesar -1256705,700, b = 0.074. Setiap peningkatan biaya (x) sebesar 1 satuan maka pengaruhnya terhadap laba (y) akan meningkat sebesar 0.074. Bila dilihat dari tabel model summary diatas maka r yang berarti koefisien korelasi yang mendekati nilai 1, berarti antara biaya dan laba mempunyai hubungan yang kuat. Bila dilihat dari nilai r square (r2) atau koefiseien determinasi sebesar 0,649 berarti 64,90 % laba dipengaruhi oleh biaya, dan 35,10% laba dipengaruhi oleh faktor lain selain dari biaya yang tidak diteliti dalam penelitian ini.
PENGARUH IKLIM ORGANISASI, KEPEMIMPINAN, KEMAMPUAN KERJA, DAN DISIPLIN KERJA TERHADAP KINERJA APARATUR SIPIL NEGARA (ASN) KABUPATEN INDRAGIRI HULU
Authors: Fikri Khusnul 
Published: April 2019

Penelitian ini dilaksanakan di Kabupaten Indragiri Hulu. Perumusan masalah adalah apakah iklim organisasi, kepemimpinan, kemampuan kerja, dan disiplin kerja secara simultan dan secara parsial berpengaruh signifikan terhadap kinerja Aparatur Sipil Negara (ASN) Kabupaten Indragiri Hulu. Tujuan penelitian adalah untuk mengetahui dan menganalisis pengaruh iklim organisasi, kepemimpinan, kemampuan kerja, dan disiplin kerja secara simultan dan secara parsial terhadap kinerja Aparatur Sipil Negara (ASN) Kabupaten Indragiri Hulu.
Dalam penelitian ini, penulis menggunakan pengambilan sampel dengan Rumus Slovin, yakni diperoleh sampel sebanyak 97 responden. Responden dalam penelitian ini adalah Aparatur Sipil Negera Kabupaten Indragiri Hulu yang berstatus Pegawai Negeri Sipil. Analisa data yang digunakan dalam penelitian ini yaitu analisa deskriptif dan analisa kuantitatif.
Hasil penlitian dapat disimpulkan bahwa scara simultan iklim organisasi, kepemimpinan, kemampuan kerja dan disiplin kerja secara bersama-sama berpengaruh signifikan terhadap kinerja Aparatur Sipil Negara. Iklim organisasi secara parsial berpengaruh signifikan terhadap kinerja, artinya semakin baik iklim organisasi maka akan meningkatkan kinerja Aparatur Sipil Negara. Kepemimpinan secara parsial berpengaruh signifikan terhadap kinerja, artinya semakin meningkat kepemimpinan maka kinerja Aparatur Sipil Negara juga akan meningkat. Kemampuan kerja secara parsial berpengaruh signifikan terhadap kinerja, artinya semakin meningkat kemampuan kerja, maka akan meningkatkan kinerja Aparatur Sipil Negara. Disiplin kerja secara parsial berpengaruh signifikan terhadap kinerja, artinya semakin bagus disiplin kerja, maka akan meningkat pula kinerja Aparatur Sipil Negara, variabel yang paling dominan yang mempengaruhi kinerja Aparatur Sipil Negara adalah variabel iklim organisasi.
ANALISIS KINERJA KEUANGAN PT. ASTRA AGORA LESTARI PERUSAHAAN YANG TERCATAT DI BURSA EFEK INDONESIA
Authors: Sudrajat Usep 
Published: April 2019

Penelitian ini dilaksanakan pada PT. Astra Agora Lestari Perusahaan Yang Tercatat Di Bursa Efek Indonesia. Perumusan masalah adalah bagaimana kinerja keuangan PT. Astra Agora Lestari perusahaan yang tercatat di Bursa Efek Indonesia. Tujuan penelitian adalah untuk mengetahui dan menganalisis kinerja keuangan PT. Astra Agora Lestari perusahaan yang tercatat di Bursa Efek Indonesia.
Data dan informasi yang digunakan dalam penelitian ini dihimpun dengan cara melihat laporan keuangan tahun 2015 s/d 2017. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis deskriptif kuantitatif dengan menganalisis kinerja keungan dengan mengukur Rasio Likuiditas, Rasio Solvabilitas, Rasio Aktivitas, dan Rasio Profitabilitas.
Hasil dari analisis dari laporan keuangan periode tahun 2015 s/d 2017 terlihat bahwa tingkat likuiditas dianalisis dari segi current ratio terjadi peningkatan tetapi dalam kondisi kurang baik, dari segi quick ratio dalam kondisi kurang baik, dari segi cash ratio dalam kondisi kurang baik. Tingkat solvabilitas dari dianalisis dari segi debt to equity ratio (DER) dalam kondisi baik, dari segi debt ratio dalam kondisi baik. Tingkat rasio aktivitas yang dianalisis dari segi Total Assets Turnover dalam kondisi kurang lancar, dari segi inventor turnover dalam kondisi lancar. Tingkat rasio profitabilitas perusahaan yang dianalisis dari segi net profit margin dalam kondisi lancar, dari segi return on investement dalam kondisi lancar dan dari segi return on equity dalam kondisi lancar.
PENGARUH KEPUASAN PELANGGAN DAN KEPERCAYAAN PELANGGAN TERHADAP LOYALITAS PELANGGAN PADA CV. TITIPAN KILAT (TIKI) RENGAT KABUPATEN INDRAGIRI HULU
Authors: Yulianda Airine 
Published: April 2019

Penelitian ini bertujuan untuk mengetahui persepsi kepuasan pelanggan dan kepercayaan pelanggan terhadap loyalitas pelanggan pada CV. Titipan Kilat (TIKI) Rengat Kabupaten Indragiri Hulu, dengan menggunakan Analisis Regresi Linier Berganda.
Metode pengumpulan data yaitu dengan menyebarkan angket atau kuesioner kepada pelanggan CV. Titipan Kilat (TIKI) Rengat Kabupaten Indragiri Hulu, sesuai jumlah sampel yang terpilih dengan menggunakan teknik Proportionate Stratified Random Sampling. Sampel yang diperoleh sebanyak 83 orang melalui Rumus Slovin. Kuesioner diberikan kepada responden yaitu para pelanggan CV. Titipan Kilat (TIKI) Rengat Kabupaten Indragiri Hulu.
Setelah dilakukan analisa data diperoleh hasil bahwa kepuasan pelanggan dan kepercayaan pelanggan secara simultan berpengaruh signifikan terhadap loyalitas pelanggan pada CV. Titipan Kilat (TIKI) Rengat Kabupaten Indragiri Hulu. Kepuasan pelanggan secara parsial berpengaruh signifikan terhadap loyalitas pelanggan CV. Titipan Kilat (TIKI) Rengat Kabupaten Indragiri Hulu. Kepercayaan pelanggan secara parsial berpengaruh signifikan terhadap loyalitas pelanggan pada CV. Titipan Kilat (TIKI) Rengat Kabupaten Indragiri Hulu. Korelasi antara variabel bebas terhadap variabel terikat sebesar 0,609, dan termasuk dalam kategori “Kuat”. Loyalitas pelanggan dijelaskan oleh kepuasan pelanggan dan kepercayaan pelanggan sebesar 0,404 atau 40,4 %, sedangkan sisanya sebesar 59,6 % dijelaskan oleh variabel lain yang tidak diteliti di dalam penelitian ini. Model Persamaan Regresi Linier Berganda : Y = 0,404 + 0,491 X1 + 0,451 X2.. Ini menunjukkan bahwa peningkatan loyalitas pelanggan ini akan didorong oleh kepuasan dan kepercayaan pelanggan.
PENGARUH RETRIBUSI PARKIR TERHADAP PENDAPATAN ASLI DAERAH DI KABUPATEN INDRAGIRI HULU
Authors: Gustika Gita Sari 
Published: April 2019

Retribusi parkir adalah fasilitas di bahu jalan umum yang disediakan oleh pemerintah daerah sebagai tempat parkir, adanya iuran atas penggunaan jasa parkir. Pada proses pendapatan retribusi parkir di Kabupaten Indragiri Hulu dipungut dari setiap masyarakat yang menggunakan jasa tempat parkir tepi jalan umum yang disediakan pemerintah daerah. Pengenaan tarif parkir berdasarkan jenis kendaraan yang digunakan oleh masyarakat. Setiap masyarakat yang menggunakan jasa parkir akan merasakan pelayaan parkir yang dilakukan oleh juru parkir. Pelayanaan yang dapat dinikmati oleh pengguna jasa parkir adanya keamanan kendaraan, dan ketertiban jalan. Agar pelayanaan tetap berjalan dengan semestinya. Selain itu, harus adanya pelayanan dapat memberi kenyamanan kepada masyarakat dan dapat meningkatkan pendapatan retribusi parkir.
Peningkatan pendapatan retribusi parkir perlu dilakukan agar meningkatkan pendapatan asli daerah Kabupaten Indragiri Hulu, karena berpengaruh pada perkembangan daerah. Permasalahan yang dikaji dalam penelitian ini adalah apakah retribusi parkir berpengaruh terhadap pendapatan asli daerah. Penelitian ini menggunakan data sekunder yang bersumber dari Badan Pendapatan Daerah Kabupaten Indragiri Hulu. Hasil dari penelitian menunjukkan bahwa retribusi parkir di Kabupaten Indragiri Hulu tidak berpengaruh yang signifikan terhadap Pendapatan Asli Daerah Kabupaten Indragiri Hulu
COMPARAÇÃO DE PARTÍCULAS TOTAIS EM SUSPENSÃO VIA DETERMINAÇÃO GRAVIMÉTRICA COM AMOSTRAGEM DE GRANDE E PEQUENO VOLUME NO ESTADO DO PARANÁ, BRASIL
Authors: Slapnig Paulo Eduardo , Vasconcelos Eliane Carvalho , Janissek Paulo Roberto 
Published: April 2019

Foram realizadas determinações de partículas totais em suspensão aplicandoseem paralelo dois métodos gravimétricos distintos: da amostragem de grandevolume, conforme metodologia de referência estabelecida na AssociaçãoBrasileira de Normas Técnicas (ABNT), Norma Brasileira (NBR) nº 9.547/97;e da amostragem de pequeno volume, conforme método definido nesteestudo. As amostragens ocorreram de outubro de 2011 a janeiro de 2012, noestado do Paraná, Brasil, em locais com características distintas. O primeirolocal em área urbana, sem atividades industriais vizinhas; no segundo localpredominava em seu entorno uma indústria papeleira; e no terceiro, aatividade de armazenamento e distribuição de fertilizantes. O método doamostrador de pequeno volume apresentou resultados equivalentes aométodo de referência na faixa de 0 a 100 μg.m-3 em ambientes com particuladofino. Verificaram-se resultados discrepantes em ambiente com partículas dediâmetros maiores. Esses resultados foram atribuídos à limitação do ajusteinicial de vazão com o método de referência e sua limitação de controleao longo da amostragem. A ampla faixa de velocidade de aspiração deamostra admitida para o método de referência aumenta a incerteza de seusresultados, principalmente em atmosferas com partículas de maior diâmetro.O método da amostragem de pequeno volume proposto demonstrou ser umaalternativa mais moderna e vantajosa para determinação de partículas totaisem suspensão, se comparado ao método de referência, e possibilita maiorflexibilidade e menor incerteza de resultados decorrentes da amostragem.
Constraining the Economic Potential of By-Product Recovery by Using a Geometallurgical Approach: The Example of Rare Earth Element Recovery at Catalão I, Brazil
Authors: Pereira Lucas , Birtel Sandra , Möckel Robert , Michaux Bruno , Silva Andre C. , Gutzmer Jens 
Published: April 2019

Abstract
Geometallurgy aims to develop and deploy predictive spatial models based on tangible and quantitative resource characteristics that are used to optimize the efficiency of minerals beneficiation and extractive metallurgy operations. While most current applications of geometallurgy are focused on the major commodity to be recovered from a mineral deposit, this contribution delineates the opportunity to use a geometallurgical approach to provide an early assessment of the economic potential of by-product recovery from an ongoing mining operation.
As a case study for this methodology, possible rare earth element (REE) recovery as a by-product of Nb production at the Chapadão mine in the Catalão I carbonatite complex is used. Catalão I is part of the Alto Paranaíba igneous province in the Goias Province of Brazil. Currently, niobium is produced in the complex as a by-product of the Chapadão phosphates mine. This production is performed in the Tailings plant, the focus of this study. REEs, albeit present in significant concentrations, are currently not recovered as by-products.
Nine samples from different stages of the Nb beneficiation process in the Tailings plant were taken and characterized by mineral liberation analyzer, X-ray powder diffraction, and bulk-rock chemistry. The recovery of REEs in each of the tailing streams was quantified by mass balance. The quantitative mineralogical and microstructural data are used to identify the most suitable approach to recover REEs as a by-product—without placing limitations on niobium production. Monazite, the most common rare earth mineral identified in the feed, occurs as Ce-rich and La-rich varieties that can be easily distinguished by scanning electron microscopy (SEM)-based image analysis. Quartz, Fe-Ti oxides, and several phosphate minerals are the main gangue minerals. The highest rare earth oxide content concentrations (1.75 wt % total rare earth oxides) and the greatest potential for REE processing are reported for the final flotation tailings stream. To place tentative economic constraints on REE recovery from the tailings material, an analogy to the Browns Range deposit in Australia is drawn. Its technical flow sheet was used to estimate the cost for a hypothetical REE production at Chapadão. Parameters derived from SEM-based image analysis were used to model possible monazite recovery and concentrate grades. This exercise illustrates that a marketable REE concentrate could be obtained at Chapadão if the process recovers at least 53% of the particles with no less than 60% of monazite on their surface. Applying capital expenditure and operational expenditure values similar to those of Browns Range suggests that such an operation would be profitable at current REE prices.
Evaluating the Most Suitable Tree Species Using Land Expectation Value: A Case Study from Plantation in North of Iran
Authors: Mohammadi Zohreh , Limaei Soleiman Mohammadi , Shahraji Teymoor Rostami 
Published: April 2019

Plantation in north of Iran is rapidly increasing by local farmers and state but it is not clear which species is most suitable for perpetual timber production. Thus, this study is carried out to evaluate the most suitable timber species among ash (Fraxinus excelsior), elm (Alnus glutinosa), maple (Acer velutinum), oak (Quercus castanifolia), bald cypress (Taxodium distichumin) in north of Iran for evaluation of most suitability using Land Expectation Value (LEV). Data such as wood price at forest road side and variable harvesting cost was collected from secondary souce especially General Office of Natural Resources in Guilan province for a period of 20 years. Average annual increment of different species derived from previous researches. Consumer Price Index (CPI) was used for deflation of stumpage price. Regression analysis was used to predict the stumpage price of different species. Then, the mean price process was determined for different species. Faustmann's formula was used to determine the LEV or Net Present Value (NPV) for a perpetual timber production of different species. The results showed that the LEV of ash, elm, maple, oak and bald cypress were 2623.883, 4653.042, 4319.9644, 2206.8788, 8064.667 (0.33 US dollar/ m3), respectively. The LEV of bald cypress was the highest, so it can be concluded that this species is the most suitable for timber production.
Comparative Assessment of Formaldehyde Concentrations in Public and Private Mortuaries in Rivers State, Nigeria
Authors: Roland Obed-Whyte, , Douglas K. E. , Akaranta O. 
Published: April 2019

Introduction: Formaldehyde is an industrial chemical that is classified as a volatile organic compound (VOC). It is commonly use in mortuaries for the preservation (embalmment) of the dead in Rivers State. Mortuary workers are occupationally exposed to formaldehyde by inhalation and skin contact. This objective/aim of the study was to measure and compare the concentration of formaldehyde in public and private mortuaries of Rivers State, Nigeria.
Methodology: This cross-sectional (field) survey was carried out in 9 public and 6 private mortuaries in Rivers State. The Time-Weighted Average (TWA) and short- Term Exposure Limit (STEL) of formaldehyde concentrations in the embalmment sections of the mortuaries were measured using a suitable formaldehyde gas detector instrument. The mortuaries were selected by a multistage sampling technique. Data were collected, entered and analyzed using XL STATA and SPSS and presented in tables and graphs.
Results: The mean TWA concentration of formaldehyde in public and private mortuaries was 2.42+-1.77 and 2.52+-0.99 ppm respectively. Also, the STEL concentration measured in public and private mortuaries were 0.91+-0.99 and 1.93+-1.22 ppm. The 8 hour TWA values exceeded OSHA (0.75) and NIOSH (0.016 ppm) standards.
Conclusion: There was a high concentration of formaldehyde in both public and private mortuaries which may pose high risk to the health of the mortuary workers of Rivers State. The study recommended health education and surveillance among mortuary workers and good engineering design in the mortuary.
Biochemical pathways mediated by KLK6 protease in breast cancer
Authors: Pampalakis Georgios , Zingkou Eleni , Sidiropoulos Konstantinos Gus , Diamandis Eleftherios P. , Zoumpourlis Vassilis , Yousef George M. , Sotiropoulou Georgia 
Published: April 2019

Kallikrein‐related peptidase 6 (KLK6) is a serine protease normally expressed in mammary tissue and aberrantly regulated in breast cancer. At physiological levels, KLK6 functions as a suppressor of breast cancer, while its aberrant overexpression (> 50‐fold higher than normal) is characteristic of a subset of breast cancers and has been linked to accelerated growth of primary breast tumors in severe combined immunodeficiency mice (Pampalakis et al. Cancer Res 2009, 69, 3779). Here, we investigated the molecular mechanisms underlying the concentration‐dependent functions of KLK6 by comparing MDA‐MB‐231 stable transfectants expressing increasing levels of KLK6 in in vitro and in vivo tumorigenicity assays (soft agar, xenograft growth, tail vein metastasis). Quantitative proteomics was applied to identify proteins that are altered upon re‐expression of KLK6 in MDA‐MB‐231 at normal or constitutive levels. Overexpression of KLK6 is associated with increased metastatic ability of breast cancer cells into lungs, increased expression of certain S100 proteins (S100A4, S100A11) and keratins (KRT), and downregulation of the apoptosis‐related proteases CASP7 and CASP8, and RABs. On the other hand, KLK6 re‐expression at physiological levels leads to inhibition of lung metastases associated with suppression of S100 proteins (S100A4, S100A10, S100A13, S100A16) and induced CASP7 and CASP8 expression. As this is the first report that KLK6 expression is associated with S100 proteins, caspases, RABs, and KRTs, we validated this finding in clinical datasets. By integrating proteomics and microarray data from breast cancer patients, we generated two composite scores, KLK6 + S100B‐S100A7 and KLK6 + S100B‐S100A14‐S100A16, to predict long‐term survival of breast cancer patients. We present previously unknown pathways implicating KLK6 in breast cancer. The findings promise to aid our understanding of the functional roles of KLK6 in breast cancer and may yield new biomarkers for the cancer types in which KLK6 is known to be aberrantly upregulated.
Retracted: High‐intensity focused ultrasound inhibits invasion and metastasis of colon cancer cells by enhancing microRNA‐124‐mediated suppression of STAT3
Authors: Li Meiying , Wan Guangsheng , Yu Hongjie , Xiong Wei 
Published: April 2019

Metastasis is the primary contributor to colorectal cancer mortality. High‐intensity focused ultrasound (HIFU) is an emerging technology for tumor therapy that exerts its effects through tumor ablation, mechanical disruption, and enhancement of immune responses. However, it remains unclear whether HIFU can influence tumor metastasis. Here, we examined the effect of HIFU on tumor metastasis of colorectal cancer cells and the underlying mechanisms. HIFU was observed to inhibit migration of HCT‐116 cells in vitro and suppress lung metastasis in a mouse model of colon cancer. In addition, HIFU up‐regulated microRNA (miR) ‐124 expression, which inhibited the activation of signal transducer and activator of transcription 3 (STAT3) and inhibited migration of HCT‐116 cells. Treatment with an inhibitor of miR‐124 reversed the effect of HIFU on cell migration. In conclusion, our results suggest that HIFU exerts anti‐metastatic effects in colon cancer, and this effect is possibly mediated via up‐regulation of miR‐124 and subsequent miR‐124‐mediated STAT3 suppression.
Effect of a Misoprostol/Phenytoin Gel on Experimentally Induced Wounds in Brook Trout—A Preliminary Study
Authors: Coutant Thomas , Vergneau-Grosset Claire , Lair Stéphane 
Published: April 2019

Abstract
Topical treatment for wound management in fish is challenging due to their aquatic life. The objective of the present study was to assess the effect of a topical gel containing misoprostol and phenytoin on the healing of skin wounds in Brook Trout Salvelinus fontinalis. Four 16- × 8-mm, full-thickness wounds were created in each trout. Fish were randomly assigned either to the misoprostol/phenytoin group (14 fish) or to the untreated control group (5 fish). In fish from the misoprostol/phenytoin group, two randomly selected wounds were topically treated with a misoprostol/phenytoin gel, while the other two wounds were left without topical treatment. Follow-up and treatment were performed every 5 d for 120 d. Different macroscopic healing indexes were recorded over time, and histological characteristics of each wound were scored at the end of the study. Treatment with misoprostol/phenytoin was associated with delayed epithelialization and wound maturation in comparison with contralateral untreated wounds. The treatment was also associated with lower histological inflammation scores and increased dermal neovascularization. The untreated wounds of fish in the misoprostol/phenytoin group showed delayed maturation and decreased healing speed and had lower inflammation scores and increased neovascularization compared to untreated control wounds. Topical treatment of wounds in Brook Trout with misoprostol/phenytoin gel at the concentration used had a local and systemic deleterious effect on wound healing. The results of the present study do not support the use of this gel at this dosage for the treatment of wounds in Brook Trout.