bluuebunny/crossref_metadata_2025_split huggingface dataset:
IN THE NAME OF THE FATHER: INHERITANCE SYSTEMS AND THE DYNAMICS OF STATE CAPACITY
Authors: Roca Fernández Èric 
Published: June 2019

AbstractThis paper examines how the degree of gender-egalitarianism embedded in inheritance rules impacts state capacity at its early stages during medieval times. We present a theoretical model in which building state capacity enables nobles to raise taxes and overcome rivals. The model addresses the use of inheritance to consolidate landholding dynasties, also accommodating interstate marriages between landed heirs. On the one hand, dynastic continuity—of utmost importance to medieval lords—directly encourages state-building. Male-biased inheritance rules historically maximize the likelihood of dynastic continuity. We weigh this effect against the indirect impact of the more frequent land-merging marriages under gender-egalitarian rules. Contrary to the literature, our results suggest that gender-egalitarian norms—offering a low probability of dynastic continuity—promote state capacity in the short run more than gender-biased norms. In the long run, results are reversed, providing a rationale for the pervasive European tradition of preference for men as heirs.
Eating habits and weight status in Finnish adolescents
Authors: Viljakainen Jannina , Figueiredo Rejane Augusta de Oliveira , Viljakainen Heli , Roos Eva , Weiderpass Elisabete , Rounge Trine B 
Published: June 2019

AbstractObjective:To investigate the association between eating habits and weight status in adolescents in Finland.Design:Cross-sectional study.Setting:The Finnish Health in Teens (Fin-HIT) study is a cohort study conducted in adolescents attending third to sixth grade in 496 schools in forty-four municipalities in Southern, Middle and Northern Finland in 2011–2014.Participants:Analyses included 10 569 adolescents from the Fin-HIT study aged 9–14 years (5005 boys and 5564 girls). Adolescents were categorized by their eating habits: healthy eaters (44·1 %; n 4661), unhealthy eaters (12·3 %; n 1298), and fruit and vegetable avoiders (43·6 %; n 4610); and they were grouped into weight status: underweight (11·1 %), normal weight (73·6 %) and excess weight (15·3 %).Results:We found an increased risk of underweight in fruit and vegetable avoiders (OR = 1·28; 95 % CI 1·12, 1·46). An irregular breakfast pattern showed an inverse association with underweight (OR = 0·70; 95 % CI 0·59, 0·84) and an increased risk of excess weight (OR = 1·56; 95 % CI 1·37, 1·77) compared with a regular breakfast pattern. An irregular dinner pattern was inversely associated with underweight (OR = 0·83; 95 % CI 0·69, 0·99) compared with a regular dinner pattern.Conclusions:Avoiding fruits and vegetables and following irregular breakfast and dinner patterns were associated with underweight and excess weight in adolescents.
Using Trials of Improved Practices to identify practices to address the double burden of malnutrition among Rwandan children
Authors: Williams Pamela A , Schnefke Courtney H , Flax Valerie L , Nyirampeta Solange , Stobaugh Heather , Routte Jesse , Musanabaganwa Clarisse , Ndayisaba Gilles , Sayinzoga Felix , Muth Mary K 
Published: June 2019

AbstractObjective:Low- and middle-income countries (LMIC) are increasingly experiencing the double burden of malnutrition. Studies to identify ‘double-duty’ actions that address both undernutrition and overweight in sub-Saharan Africa are needed. We aimed to identify acceptable behaviours to achieve more optimal feeding and physical activity practices among both under- and overweight children in Rwanda, a sub-Saharan LMIC with one of the largest recent increases in child overweight.Design:We used the Trials of Improved Practices (TIPs) method. During three household visits over 1·5 weeks, we used structured interviews and unstructured observations to collect data on infant and young child feeding practices and caregivers’ experiences with testing recommended practices.Setting:An urban district and a rural district in Rwanda.Participants:Caregivers with an under- or overweight child from 6 to 59 months of age (n 136).Results:We identified twenty-five specific recommended practices that caregivers of both under- and overweight children agreed to try. The most frequently recommended practices were related to dietary diversity, food quantity, and hygiene and food handling. The most commonly cited reason for trying a new practice was its benefits to the child’s health and growth. Financial constraints and limited food availability were common barriers. Nearly all caregivers said they were willing to continue the practices and recommend them to others.Conclusions:These practices show potential for addressing the double burden as part of a broader intervention. Still, further research is needed to determine whether caregivers can maintain the behaviours and their direct impact on both under- and overweight.
The regional consequences of authoritarian power-sharing: Politburo representation and fiscal redistribution in China
Authors: Sheng Yumin 
Published: June 2019

AbstractMuch political economy research examines how higher-level political representation of the constituent jurisdictions affects resource redistribution among the lower-level units in democracies, but little work has probed the redistributive consequences of regional political representation under dictatorship. This study investigates the effect of membership for provincial officials in the Politburo of the single-ruling Chinese Communist Party (CCP) on fiscal resource flows between the central government and provincial governments in reform-era China. I find robust evidence that the provinces overseen by CCP Politburo members tended to remit more budgetary revenues to the center but did not receive larger central budgetary subsidies. This is consistent with a territorial logic of authoritarian power-sharing in single-party states, which suggests that the regionally selective presence at a collective ruling-party decision-making forum for subnational officials aims at tighter political control to help induce greater policy compliance from below.
Sulfur metabolites that facilitate oceanic phytoplankton–bacteria carbon flux
Authors: Landa Marine , Burns Andrew S , Durham Bryndan P , Esson Kaitlin , Nowinski Brent , Sharma Shalabh , Vorobev Alexey , Nielsen Torben , Kiene Ronald P , Moran Mary Ann 
Published: June 2019

Abstract
Unlike biologically available nitrogen and phosphorus, which are often at limiting concentrations in surface seawater, sulfur in the form of sulfate is plentiful and not considered to constrain marine microbial activity. Nonetheless, in a model system in which a marine bacterium obtains all of its carbon from co-cultured phytoplankton, bacterial gene expression suggests that at least seven dissolved organic sulfur (DOS) metabolites support bacterial heterotrophy. These labile exometabolites of marine dinoflagellates and diatoms include taurine, N-acetyltaurine, isethionate, choline-O-sulfate, cysteate, 2,3-dihydroxypropane-1-sulfonate (DHPS), and dimethylsulfoniopropionate (DMSP). Leveraging from the compounds identified in this model system, we assessed the role of sulfur metabolites in the ocean carbon cycle by mining the Tara Oceans dataset for diagnostic genes. In the 1.4 million bacterial genome equivalents surveyed, estimates of the frequency of genomes harboring the capability for DOS metabolite utilization ranged broadly, from only 1 out of every 190 genomes (for the C2 sulfonate isethionate) to 1 out of every 5 (for the sulfonium compound DMSP). Bacteria able to participate in DOS transformations are dominated by Alphaproteobacteria in the surface ocean, but by SAR324, Acidimicrobiia, and Gammaproteobacteria at mesopelagic depths, where the capability for utilization occurs in higher frequency than in surface bacteria for more than half the sulfur metabolites. The discovery of an abundant and diverse suite of marine bacteria with the genetic capacity for DOS transformation argues for an important role for sulfur metabolites in the pelagic ocean carbon cycle.
Indications for enzymatic denitrification to N2O at low pH in an ammonia-oxidizing archaeon
Authors: Jung Man-Young , Gwak Joo-Han , Rohe Lena , Giesemann Anette , Kim Jong-Geol , Well Reinhard , Madsen Eugene L , Herbold Craig W , Wagner Michael , Rhee Sung-Keun 
Published: June 2019

Abstract
Nitrous oxide (N2O) is a key climate change gas and nitrifying microbes living in terrestrial ecosystems contribute significantly to its formation. Many soils are acidic and global change will cause acidification of aquatic and terrestrial ecosystems, but the effect of decreasing pH on N2O formation by nitrifiers is poorly understood. Here, we used isotope-ratio mass spectrometry to investigate the effect of acidification on production of N2O by pure cultures of two ammonia-oxidizing archaea (AOA; Nitrosocosmicus oleophilus and Nitrosotenuis chungbukensis) and an ammonia-oxidizing bacterium (AOB; Nitrosomonas europaea). For all three strains acidification led to increased emission of N2O. However, changes of 15N site preference (SP) values within the N2O molecule (as indicators of pathways for N2O formation), caused by decreasing pH, were highly different between the tested AOA and AOB. While acidification decreased the SP value in the AOB strain, SP values increased to a maximum value of 29‰ in N. oleophilus. In addition, 15N-nitrite tracer experiments showed that acidification boosted nitrite transformation into N2O in all strains, but the incorporation rate was different for each ammonia oxidizer. Unexpectedly, for N. oleophilus more than 50% of the N2O produced at pH 5.5 had both nitrogen atoms from nitrite and we demonstrated that under these conditions expression of a putative cytochrome P450 NO reductase is strongly upregulated. Collectively, our results indicate that N. oleophilus might be able to enzymatically denitrify nitrite to N2O at low pH.
Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor
Authors: Nightingale Adrian M. , Leong Chi Leng , Burnish Rachel A. , Hassan Sammer-ul , Zhang Yu , Clough Geraldine F. , Boutelle Martyn G. , Voegeli David , Niu Xize 
Published: June 2019

AbstractKnowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule levels that combines continuous fluid sampling with in situ analysis using wet-chemical assays (with the specific assay interchangeable depending on the target biomolecule). The microfluidic device employs a droplet flow regime to maximise the temporal response of the device, using a screw-driven push-pull peristaltic micropump to robustly produce nanolitre-sized droplets. The fully integrated sensor is contained within a small (palm-sized) footprint, is fully autonomous, and features high measurement frequency (a measurement every few seconds) meaning deviations from steady-state levels are quickly detected. We demonstrate how the sensor can track perturbed glucose and lactate levels in dermal tissue with results in close agreement with standard off-line analysis and consistent with changes in peripheral blood levels.
A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies
Authors: Happonen Lotta , Hauri Simon , Svensson Birkedal Gabriel , Karlsson Christofer , de Neergaard Therese , Khakzad Hamed , Nordenfelt Pontus , Wikström Mats , Wisniewska Magdalena , Björck Lars , Malmström Lars , Malmström Johan 
Published: June 2019

AbstractA fundamental challenge in medical microbiology is to characterize the dynamic protein–protein interaction networks formed at the host–pathogen interface. Here, we generate a quantitative interaction map between the significant human pathogen,Streptococcus pyogenes, and proteins from human saliva and plasma obtained via complementary affinity-purification and bacterial-surface centered enrichment strategies and quantitative mass spectrometry. Perturbation of the network using immunoglobulin protease cleavage, mixtures of different concentrations of saliva and plasma, and differentS. pyogenesserotypes and their isogenic mutants, reveals how changing microenvironments alter the interconnectivity of the interaction map. The importance of host immunoglobulins for the interaction with human complement proteins is demonstrated and potential protective epitopes of importance for phagocytosis ofS. pyogenescells are localized. The interaction map confirms several previously described protein–protein interactions; however, it also reveals a multitude of additional interactions, with possible implications for host–pathogen interactions involving other bacterial species.
Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
Authors: Bitschar Katharina , Sauer Birgit , Focken Jule , Dehmer Hanna , Moos Sonja , Konnerth Martin , Schilling Nadine A. , Grond Stephanie , Kalbacher Hubert , Kurschus Florian C. , Götz Friedrich , Krismer Bernhard , Peschel Andreas , Schittek Birgit 
Published: June 2019

AbstractRecently our groups discovered lugdunin, a new cyclic peptide antibiotic that inhibits Staphylococcus aureus epithelial colonization in humans and rodents. In this work, we analyzed its immuno-modulatory and antimicrobial potential as a single agent or in combination with other microbiota- or host-derived factors. We show that pretreatment of primary human keratinocytes or mouse skin with lugdunin in combination with microbiota-derived factors results in a significant reduction of S. aureus colonization. Moreover, lugdunin increases expression and release of LL-37 and CXCL8/MIP-2 in human keratinocytes and mouse skin, and results in the recruitment of monocytes and neutrophils in vivo, both by a TLR/MyD88-dependent mechanism. Interestingly, S. aureus elimination by lugdunin is additionally achieved by synergistic antimicrobial activity with LL-37 and dermcidin-derived peptides. In summary, our results indicate that lugdunin provides multi-level protection against S. aureus and may thus become a promising treatment option for S. aureus skin infections in the future.
Nonreciprocal charge transport at topological insulator/superconductor interface
Authors: Yasuda Kenji , Yasuda Hironori , Liang Tian , Yoshimi Ryutaro , Tsukazaki Atsushi , Takahashi Kei S. , Nagaosa Naoto , Kawasaki Masashi , Tokura Yoshinori 
Published: June 2019

AbstractTopological superconductor is attracting growing interest for its potential application to topological quantum computation. The superconducting proximity effect on the topological insulator surface state is one promising way to yield topological superconductivity. The superconductivity realized at the interface between Bi2Te3 and non-superconductor FeTe is one such candidate. Here, to detect the mutual interaction between superconductivity and topological surface state, we investigate nonreciprocal transport; i.e., current-direction dependent resistance, which is sensitive to the broken inversion symmetry of the electronic state. The largely enhanced nonreciprocal phenomenon is detected in the Bi2Te3/FeTe heterostructure associated with the superconducting transition. The emergent nonreciprocal signal at low magnetic fields is attributed to the current-induced modulation of supercurrent density under the in-plane magnetic fields due to the spin-momentum locking. The angular dependence of the signal reveals the symmetry of superconductivity and indicates the existence of another mechanism of nonreciprocal transport at high fields.
Immature excitatory neurons develop during adolescence in the human amygdala
Authors: Sorrells Shawn F. , Paredes Mercedes F. , Velmeshev Dmitry , Herranz-Pérez Vicente , Sandoval Kadellyn , Mayer Simone , Chang Edward F. , Insausti Ricardo , Kriegstein Arnold R. , Rubenstein John L. , Manuel Garcia-Verdugo Jose , Huang Eric J. , Alvarez-Buylla Arturo 
Published: June 2019

AbstractThe human amygdala grows during childhood, and its abnormal development is linked to mood disorders. The primate amygdala contains a large population of immature neurons in the paralaminar nuclei (PL), suggesting protracted development and possibly neurogenesis. Here we studied human PL development from embryonic stages to adulthood. The PL develops next to the caudal ganglionic eminence, which generates inhibitory interneurons, yet most PL neurons express excitatory markers. In children, most PL cells are immature (DCX+PSA-NCAM+), and during adolescence many transition into mature (TBR1+VGLUT2+) neurons. Immature PL neurons persist into old age, yet local progenitor proliferation sharply decreases in infants. Using single nuclei RNA sequencing, we identify the transcriptional profile of immature excitatory neurons in the human amygdala between 4–15 years. We conclude that the human PL contains excitatory neurons that remain immature for decades, a possible substrate for persistent plasticity at the interface of the hippocampus and amygdala.
Excitation of coherent second sound waves in a dense magnon gas
Authors: Tiberkevich V. , Borisenko I. V. , Nowik-Boltyk P. , Demidov V. E. , Rinkevich A. B. , Demokritov S. O. , Slavin A. N. 
Published: June 2019

AbstractSecond sound is a quantum mechanical effect manifesting itself as a wave-like (in contrast with diffusion) heat transfer, or energy propagation, in a gas of quasi-particles. So far, this phenomenon has been observed only in an equilibrium gas of phonons existing in liquid/solid helium, or in dielectric crystals (Bi, NaF) at low temperatures. Here, we report observation of a room-temperature magnonic second sound, or a wave-like transport of both energy and spin angular momentum, in a quasi-equilibrium gas of magnons undergoing Bose-Einstein condensation (BEC) in a ferrite film. Due to the contact of the magnon gas with pumping photons and phonons, dispersion of the magnonic second sound differ qualitatively from the phononic case, as there is no diffusion regime, and the second sound velocity remains finite at low wavenumbers. Formation of BEC in the gas of magnons modifies the second sound properties by creating an additional channel of energy relaxation.
RETRACTED ARTICLE: Pharmacokinetics, Biodistribution, and Anti-Angiogenesis Efficacy of Diamino Propane Tetraiodothyroacetic Acid-conjugated Biodegradable Polymeric Nanoparticle
Authors: Li Weikun , Yalcin Murat , Bharali Dhruba J. , Lin Qishan , Godugu Kavitha , Fujioka Kazutoshi , Keating Kelly A. , Mousa Shaker A. 
Published: June 2019

AbstractThe anti-angiogenic agent, diamino propane tetraiodothyroacetic acid (DAT), is a thyro-integrin (integrin αvβ3) antagonist anticancer agent that works via genetic and nongenetic actions. Tetraiodothyroacetic acid (tetrac) and DAT as thyroid hormone derivatives influence gene expression after they transport across cellular membranes. To restrict the action of DAT to the integrin αvβ3 receptors on the cell surface, we used DAT-conjugated PLGA nanoparticles (NDAT) in an active targeting mode to bind to these receptors. Preparation and characterization of NDAT is described, and both in vitro and in vivo experiments were done to compare DAT to NDAT. Intracellular uptake and distribution of DAT and NDAT in U87 glioblastoma cells were evaluated using confocal microscopy and showed that DAT reached the nucleus, but NDAT was restricted from the nucleus. Pharmacokinetic studies using LC-MS/MS analysis in male C57BL/6 mice showed that administration of NDAT improved the area under the drug concentration curve AUC(0–48 h) by 4-fold at a dose of 3 mg/kg when compared with DAT, and Cmax of NDAT (4363 ng/mL) was 8-fold greater than that of DAT (548 ng/mL). Biodistribution studies in the mice showed that the concentrations of NDAT were higher than DAT/Cremophor EL micelles in heart, lung, liver, spleen, and kidney. In another mouse model using female NCr nude homozygous mice with U87 xenografts, tumor growth was significantly decreased at doses of 1 and 3 mg/kg of NDAT. In the chick chorioallantoic membrane (CAM) assay used to measure angiogenesis, DAT (500 ng/CAM) resulted in 48% inhibition of angiogenesis levels. In comparison, NDAT at low dose (50 ng/CAM) showed 45% inhibition of angiogenesis levels. Our investigation of NDAT bridges the study of polymeric nanoparticles and anti-angiogenic agents and offers new insight for the rational design of anti-angiogenic agents.
Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques
Authors: Schmidt Augusto F. , Kannan Paranthaman S. , Bridges James P. , Filuta Alyssa , Lipps Dakota , Kemp Matthew , Miller Lisa A. , Kallapur Suhas G. , Xu Yan , Whitsett Jeffrey A. , Jobe Alan H. 
Published: June 2019

AbstractAntenatal corticosteroids (ANS) are the major intervention to decrease respiratory distress syndrome and mortality from premature birth and are standard of care. The use of ANS is expanding to include new indications and gestational ages, although the recommended dosing was never optimized. The most widely used treatment is two intramuscular doses of a 1:1 mixture of betamethasone-phosphate (Beta-P) and betamethasone-acetate (Beta-Ac) – the clinical drug. We tested in a primate model the efficacy of the slow release Beta-Ac alone for enhancing fetal lung maturation and to reduce fetal corticosteroid exposure and potential toxic effects. Pregnant rhesus macaques at 127 days of gestation (80% of term) were treated with either the clinical drug (0.25 mg/kg) or Beta-Ac (0.125 mg/kg). Beta-Ac alone increased lung compliance and surfactant concentration in the fetal lung equivalently to the clinical drug. By transcriptome analyses the early suppression of genes associated with immune responses and developmental pathways were less affected by Beta-Ac than the clinical drug. Promoter and regulatory analysis prediction identified differentially expressed genes targeted by the glucocorticoid receptor in the lung. At 5 days the clinical drug suppressed genes associated with neuronal development and differentiation in the fetal hippocampus compared to control, while low dose Beta-Ac alone did not. A low dose ANS treatment with Beta-Ac should be assessed for efficacy in human trials.