bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconceptualization innovative moments as a predictor of symptomatology improvement in treatment for depression
Authors: Fernández‐Navarro Pablo , Rosa Catarina , Sousa Inês , Moutinho Vanessa , Antunes Ana , Magalhães Carina , Ribeiro António P. , Gonçalves Miguel M. 
Published: July 2018

AbstractObjectivesIn previous studies, reconceptualization innovative moments were associated with successful psychotherapy. Reconceptualization has two components—(a) a positive temporal contrast between the past self and the present self (contrasting self [CS]) and (b) a description of how and/or why this change has occurred (change process [CP])—from the perspective of the client. The aim of this study is to analyse if CS and CP have the same association with outcomes as reconceptualization.MethodSixteen cases of clients with major depression (305 sessions) were analysed. Longitudinal regression models were used to explore if proportions of CS, CP, and reconceptualization predicted outcome measures and if outcome measures predicted CS, CP, and reconceptualization.ResultsReconceptualization is less frequent than CS and CP taken separately, but reconceptualization was a better predictor of treatment outcomes than were its separate components. Moreover, symptom improvement did not predict reconceptualization.ConclusionThe construction of new meanings is important in improving depressive symptomatology. Psychotherapists can elicit these new meanings in their regular practice by posing questions that may help clients to conceptualize what is changing in themselves (CS) and questions of how this change is occurring (CP). The construction of an integrative account of these new meanings is associated with psychotherapeutic gains, and thus, reconceptualizing change could improve symptoms of depression.
Evaluation of oral pharmacokinetics, in vitro metabolism, blood partitioning and plasma protein binding of novel antidiabetic agent, S009‐0629 in rats
Authors: Valicherla Guru Raghavendra , Italiya Kishan Shamjibhai , Gupta Chandra Prakash , Mishra Shachi , Riyazuddin Mohammed , Syed Anees Ahmed , Singh Sandeep Kumar , Shahi Sudhir , Taneja Gaurav , Wahajuddin Mohammad , Goel Atul , Gayen Jiaur Rahaman 
Published: July 2018

AbstractS009‐0629 [methyl‐8‐(methylthio)‐2‐phenyl‐6‐p‐tolyl‐4,5‐dihydro‐2H‐benzo[e]indazole‐9‐carboxylate] is a novel antidiabetic agent with PTP1B inhibitory activity. In this study, we have investigated the in vitro metabolic stability, plasma protein binding, blood partitioning, and oral pharmacokinetic study of S009‐0629 in rats. The plasma protein binding, blood partitioning, and metabolic stability were determined by HPLC method. The oral pharmacokinetic study was analyzed by liquid chromatography coupled mass spectrometry (LC‐MS/MS) method. The plasma protein binding of S009‐0629 using modified charcoal adsorption method at 5 and 10 µg/mL was 80.58 ± 1.04% and 81.95 ± 1.15%, respectively. The KRBC/PL of S009‐0629 was independent of concentration and time. The in‐vitro half‐life of S009‐0629 at 5 and 10 µM using rat liver microsomes was determined as 273 ± 24.46 and 281.67 ± 26.53 min, respectively. After oral administration, S009‐0629 exhibited Cmax 55.51 ± 1.18 ng/mL was observed at 18 hr (tmax). S009‐0629 was found to have the large apparent volume of distribution (1,894.93 ± 363.67 L/kg). Oral in‐vivo t1/2 of S009‐0629 was found to be 41.23 ± 5.96 hr. A rapid and highly sensitive LC‐MS/MS method was validated for S009‐0629 in rat plasma. S009‐0629 has high plasma protein binding and low hepatic extraction. S009‐0629 has no affinity with human P‐gp and BCRP in ATPase assay. After oral dosing, S009‐0629 has slow absorption and elimination in rats.
Landscape influence on the local distribution of western pond turtles
Authors: Horn Robert B. , Gervais Jennifer A. 
Published: July 2018

AbstractSpatial and temporal scales are important for understanding habitat associations because organisms have neither unbounded mobility nor perfect knowledge of their environment, but still must make decisions on where to seek food, shelter, and mates. Semi‐aquatic turtles exemplify the need to evaluate potential habitat characteristics at a range of scales, because their ectothermy makes these animals particularly sensitive to local environmental conditions, yet their limited mobility spatially constrains selection of microsites. Microsite choice may also be sensitive to larger geographic context. We explored site occupancy and abundance of western pond turtles (Actinemys [Emys] marmorata) as a function of environmental variables over a range of spatial scales up to that of the entire watershed. We modeled occupancy at ponds and abundance at river sites using data from surveys conducted at 50 ponds and 58 river locations throughout the South Umpqua, Umpqua, and North Umpqua watersheds in western Oregon, USA in 1999–2000. The South Umpqua supported the greatest abundance of western pond turtles in rivers and the highest rates of occupancy in ponds. No turtles were detected in rivers of the North Umpqua, and only low numbers were detected in ponds in that watershed. Increasing amount of potential relative solar radiation was associated with increased probability of pond occupancy, particularly in the North Umpqua watershed. Pond turtle abundance in rivers increased with increasing distance to nearest pond, decreasing area of nearby ponds, and increasing area of nearby wetland habitat of all types, particularly in the Klamath Mountain and Coast Range physiographic provinces, which dominate the South Umpqua and Umpqua watersheds, respectively. Western pond‐turtle occupancy and abundance varied with both broad‐scale and fine‐scale habitat features, not solely to the fine‐scale features that are most often measured.
Nutrition and mycorrhizae affect interspecific patterns of seedling growth on coarse wood and mineral soil substrates
Authors: Willis John L. , Walters Michael B. 
Published: July 2018

AbstractSmaller‐seeded tree species often require mineral soil and coarse woody debris (CWD) to establish. Limited data suggest that species‐based variation in tree seedling–CWDrelations exists; however, the generalizability of this pattern and its mechanistic basis remain unknown. We investigated interspecific substrate–seedling relations and the potential that differences in mycorrhizal status and substrate nutrition underlie these patterns with a potted plant experiment. Eight temperate tree species were grown in a lath shade house on six species ofCWDand mineral soil that had either been sterilized with gamma irradiation or left untreated to separate the effects of mycorrhizae from substrate nutrition. We assessed the impact of substrate identity on height growth and investigated possible mechanisms via relating growth to substrate inorganic N concentration, seedling foliar N (%), and mycorrhizal colonization. Seedling height varied across substrates consistently among species (i.e., substrate effects were strong, but seedling species x substrate interactions were weak). Seedlings were generally tallest on mineral soil followed byBetula papyriferaandThuja occidentalisCWD, and shortest onB. alleghaniensisorAcer saccharumCWD. Sterilization main effects on height were not significant; however, the response of species to sterilization varied, asAcer rubrumandT. occidentalisseedlings were significantly shorter on sterilized substrate. For all seedling species, growth correlated positively with substrate [N] and foliar N. Among the four species examined for mycorrhizae, root colonization density was highest on mineral soil and lowest onA. saccharumandB. alleghaniensisCWD). For these species, mean colonization density was more strongly associated with mean seedling height than substrate inorganic [N]. Beneficial mycorrhizal effects were suggested by positive height–mycorrhizal root density relationships forB. alleghaniensis,A. rubrum, andT. occidentalis. Collectively, for the group of northern hardwood tree species examined in this study, these results demonstrate that in a controlled environment, most species grow best on mineral soil,B. alleghaniensis and Picea glaucaattained maximum growth onCWD, species‐specific growth responses occur onCWD, and that substrate nutrient availability and mycorrhizal fungi contribute to the variation observed in seedling growth response across substrates.
Autoantibodies reactive to PEP08 are clinically related with morbidity and severity of interstitial lung disease in connective tissue diseases
Authors: Okumura Maiko , Ozawa Tatsuhiko , Hamana Hiroshi , Norimatsu Yu , Tsuda Reina , Kobayashi Eiji , Shinoda Koichiro , Taki Hirofumi , Tobe Kazuyuki , Imura Johji , Sugiyama Eiji , Kishi Hiroyuki , Muraguchi Atsushi 
Published: July 2018

AbstractAnti‐Ro52 autoantibodies (Ro52‐autoAbs) appear in the sera of connective tissue disease (CTD) patients with interstitial lung disease (ILD). Studies using patient sera have shown a correlation between the generation of Ro52‐autoAbs and the clinical morbidity and severity of CTD with ILD. In this study, we used a single B‐cell manipulating technology and obtained 12 different monoclonal Ro52‐autoAbs (mRo52‐autoAbs) from the selected four patients suffering from severe ILD with a high titer of Ro52‐autoAbs in their sera. Western blot analysis revealed that 11 of 12 mRo52‐autoAbs bound to the coiled‐coil domain of Ro52. Competitive ELISA demonstrated that mRo52‐autoAbs competed with each other to bind to Ro52. Epitope mapping showed that two of them specifically bound to a peptide (PEP08) in the coiled‐coil domain. We then examined the titer of Ro52‐autoAbs in the sera of 192 CTD patients and assessed the relationship between the serum levels of Ro52‐autoAbs that were reactive to PEP08 peptide and the clinical morbidity and severity of ILD. Statistical analysis revealed that the production of PEP08‐reactive Ro52‐autoAbs correlated with the morbidity and severity of ILD in CTD. Assessment of the production of PEP08‐reactive Ro52‐autoAbs in autoimmune diseases is useful for predicting the clinical morbidity of ILD.
Characterizing the power cost of virtualization environments
Authors: Tadesse Senay Semu , Chiasserini Carla Fabiana , Malandrino Francesco 
Published: July 2018

AbstractVirtualization is a key building block of next‐generation mobile networks. It can be implemented through two main approaches: traditional virtual machines (VMs) and lighter‐weight containers. Our objective in this paper is to compare these approaches and study the power consumption they are associated with. To this end, we perform a large set of real‐world measurements, using both synthetic workloads and real‐world applications, and use them to model the relationship between the resource usage of the hosted application and the power consumption of both VMs and containers hosting it. We find that containers incur substantially lower power consumption than VMs and that such consumption increases more slowly with the application load.
Numerical study of supercritical CO2 and proppant transport in different geometrical fractures
Authors: Wang Haizhu , Wang Meng , Yang Bing , Lu Qun , Zheng Yong , Zhao Heqian 
Published: July 2018

AbstractSupercritical CO2 (SC‐CO2) fracturing, as a kind of waterless fracturing method, is an effective treatment in the unconventional oil and gas industry. Due to its characteristic lower viscosity, supercritical CO2 fracturing is likely to create thin and long fractures that connect pre‐existing natural fractures and generate complex fractures. It is therefore very challenging to predict how far supercritical CO2 carrying proppant can go and how proppant will be transported in natural fractures, when natural fractures are contacted or penetrated by induced fractures. In this paper, proppant transport with supercritical CO2 in fractures was analyzed using the computational fluid dynamics method. Three types of fractures – planar fractures, T‐shape fractures and crossing‐shape fractures – were modeled. Five parametrical cases were studied using the T‐shape and crossing‐shape models. Results show that, for T‐shape fracture cases, a turbulent flow regime might develop at a fracture junction, which can make proppant propagate to natural fractures. For crossing‐shape fractures, a turbulent flow takes place behind the fracture junction, which causes a little sand dune to form downstream of the induced fracture. With the reduction in the width of the natural fracture, the height of the sand bank at the thinner natural fracture is higher than that at the wider natural fracture. Using a proppant whose density and diameter are respectively less than 1540 kg/m3 and 0.25 mm, as well as a sand‐carrying fluid whose sand ratio ranges from 8% to 10% and injection rate exceeds 2 kg/s, is beneficial to prop natural fractures. Moreover, the larger the intersection angle of the crossing‐shape fracture is, the more difficult it is for proppant to enter natural fractures. This study reveals the influence of fracture geometry on proppant transport with SC‐CO2. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd.
“Reverse” pyridyl cryptands as hosts for viologens
Authors: Pederson Adam M.‐P. , Price Terry L. , Schoonover Daniel V. , Slebodnick Carla , Gibson Harry W. 
Published: July 2018

AbstractTwo new cryptands, 2 and 4, were prepared from bis(m‐phenylene)‐32‐crown‐10 (BMP32) 5,5'‐diacid chloride and dibenzo‐30‐crown‐10 (DB30) 4,4'‐diacid chloride, respectively, by reaction with pyridine‐2,6‐dimethanol. The resultant cryptands 2 and 4 have the ester moieties reversed from the previously reported isomers, 1 and 3. These “reverse” cryptands display lower association constants with viologen derivatives than the original cryptands; this is rationalized by the conjugation of the ester moieties with the aromatic rings, which reduces their electron‐donating properties and offsets the increased basicity of the pyridyl nitrogen atoms. The crystal structure of the BMP32‐based cryptand 2 indeed confirms the coplanarity of the ester and aromatic moieties and indicates that, as a result, the available cavity is quite small and that the pyridyl nitrogen atom points away from the cavity.
A retrospective and prospective assessment of the zero‐markup drug reform in China from the perspective of policy diffusion
Authors: Deng Jianwei , Tian Huilin , Guo Yilun , Ma Tengyang , Sun Yangjie , Zhang Shiyang , Yang Tianan , Tian Xu 
Published: July 2018

SummaryThe zero‐markup drug policy is an important component of the new round of Chinese health care reform that began in 2009 to promote the separation between medical and pharmaceutical services, reduce patients' medical burden, and improve the medical supply security system. Over the past 8 years, the zero‐markup drug reform policy has been carried out in 4 pilot rounds (a policy diffusion model with Chinese characteristics) and has been promoted throughout the mainland China. At this critical point, it is necessary to review this policy systematically. Therefore, based on the literature, government documents, and interview records, this study analyzed the characteristics, progress, achievements, challenges, and recommendations of zero‐markup drug reform by using the policy diffusion theory. The study found that zero‐markup drug reform has completed its initial diffusion by use of the “policy experiment” method and has reduced drug prices and patients' burden to a certain extent. However, in the next phase of policy diffusion, the reform still requires adjustment and innovative measures to respond to future challenges. Generally speaking, as China's unique health care reform practice, the experience of zero‐markup drug reform could be used as a reference for other countries to control drug prices, separate medical and pharmaceutical services, and establish a modern system of hospital operation.
Thermal optimization of tapered pin fin exposed to nonuniform surface heat transfer coefficient
Authors: Taamneh Yazan , Alrbai Mohammad , Sathyamurthy Ravishankar 
Published: July 2018

AbstractIn the present work, thermal analysis and design optimization of tapered pin fin subjected to variable surface heat transfer coefficient have been numerically carried out. It is well known that heat is transferred through the fin by conduction along its length and dissipated from the fin surface via natural convection to the ambient. The thermal analysis and the optimum dimension were carried out using finite element (FE) modeling software ANSYS‐17.2. The thermal performance of the tapered pin fin has been studied over a wide range of physical dimensions. In addition, the effect of base to tip surface heat transfer coefficient ratio (ε) on the fin performance is evaluated. It was found that the effect of variable heat transfer coefficient has a significant impact on the fin efficiency. The rate of increase of fin efficiency was lower in the low as well as in high range of ε, meanwhile, it was steeper in the intermediate range of ε. It was also observed that the optimal values of the heat dissipation were higher for lower values of ε at the same conditions.
Conservative management of placental invasion anomalies with an intracavitary suture technique
Authors: Acar Ali , Ercan Fedi , Pekin Aybike , Elci Atilgan Adeviye , Sayal Hasan Berkan , Balci Osman , Gorkemli Hüseyin 
Published: July 2018

AbstractObjectiveTo assess the efficacy and safety of a new surgical suture technique for uterine preservation among patients with placental invasion anomalies.MethodsThe present prospective case series included women diagnosed with placental invasion anomalies undergoing cesarean deliveries who desired future fertility at the obstetrics department of a Turkish university hospital between January 10, 2013, and April 20, 2017. Patients were diagnosed with ultrasonography and Doppler ultrasonography; the type of placental invasion anomaly (placenta accreta, increta, or percreta) was confirmed intraoperatively. Surgical management involved an intracavitary suture technique after the proximal branch of the uterine artery was clamped and utero–ovarian anastomoses had been blocked. Outcomes included units of blood transfused, intraoperative and postoperative adverse events, duration of hospital admission, and hysterectomy rate.ResultsThere were 62 patients included. The mean operative blood loss was 1350 ± 750 mL (range 600–5000 mL). Blood transfusion required a mean of four units (range 2–15). Bleeding was controlled with the intracavitary sutures in 58 (94%) patients. Three patients experienced postoperative wound infections and two patients developed endometritis that required therapy with broad‐spectrum antibiotics. The mean length of hospital stay was 3.6 ± 1.6 days (range 2–11). None of the patients required reoperation after the initial surgery.ConclusionThe novel uterus‐sparing suture technique was highly effective among patients with placental invasion anomalies.
Affordances and effects of introducing social media within eParticipation—Findings from government‐initiated Indonesian project
Authors: Dini Alfatika Aunuriella , Sæbo Øystein , Wahid Fathul 
Published: July 2018

AbstractIn this paper, we explore “LAPOR!,” a government‐developed social media project within a young democratic society. LAPOR! is a system for citizens to report various issues to the public and represents a novel example of a custom‐made tool by the Indonesian government. We examine the system's action potentials, constraining factors, and effects identified through the lenses of the technology affordances theory. LAPOR! introduces different affordances that influences citizens' level of engagement compared with mainstream social media. We contribute by fostering a better understanding of the development of custom‐made social media initiatives. Moreover, we contribute knowledge to the field by investigating eParticipation projects from emerging economies, such as Indonesia, a context that has not been thoroughly investigated.
LncRNA FAL1 is a negative prognostic biomarker and exhibits pro‐oncogenic function in osteosarcoma
Authors: Wang Yanlong , Zhao Zhenyu , Zhang Shenqi , Li Zhaopeng , Li Dawei , Yang Sen , Zhang Hai , Zeng Xiangyu , Liu Jianyu 
Published: July 2018

AbstractLong noncoding RNA focally amplified lncRNA on chromosome 1 (FAL1) plays an important role in the development of several human malignancy entities. However, the expression and function of FAL1 in the carcinogenesis and development of osteosarcoma remain unknown. In this study, we detected the FAL1 levels in human osteosarcoma tissues and cell lines by quantitative real‐time polymerase chain reaction and investigated its role in osteosarcoma using in vitro assays. Our results showed that FAL1 expression was significantly upregulated in human osteosarcoma tissues and cell lines compared with their normal controls. FAL1 expression level was positively correlated with the distance metastasis (P = .008) and tumor stage (
P = .013). Higher expression of FAL1 conferred a significantly poorer survival, as determined by the Kaplan‐Meier method with the log‐rank test. Multivariate Cox proportional hazards analysis revealed that FAL1 was probably an independent risk of overall survival. Additionally, the serum FAL1 expression level was associated with osteosarcoma status in patients. Receiver operating characteristic curve analysis demonstrated that FAL1 expression was different between patients with osteosarcoma and healthy cohorts (area under the curve, 0.839; P < .001). Furthermore, knockdown of FAL1 by small interfering RNA significantly inhibited cell proliferation via inducing G2/M arrest in osteosarcoma cells. Depletion of FAL1 also suppressed osteosarcoma cell migration and invasion, which might be mediated by inhibiting the epithelial‐mesenchymal transition (EMT) program. Taken together, our study showed that lncRNA FAL1 exhibits an important pro‐oncogenic effect on osteosarcoma progression by targeting EMT, which may serve as a potential therapeutic target for osteosarcoma.
Foliar epidermal micromorphology and its taxonomic implications in some selected species of Athyriaceae
Authors: Shah Syed Nasar , Ahmad Mushtaq , Zafar Muhammad , Razzaq Abdul , Malik Khafsa , Rashid Neelam , Ullah Fazal , Iqbal Majid , Zaman Wajid 
Published: July 2018

AbstractFor the robust identification of taxonomically complex fern family like Athyriaceae, light and scanning electron microscopy is significance implications. This article present first microscopic investigation of foliar micromorphology of 3 genera and 10 species belonging to Athyriaceae namely, Athyrium, Deparia, and Diplazium were collected from different localities in Malakand Division, Northern Pakistan. In present study we compare foliar micromorphology of all 10 species using standard protocols of light microcopy (LM) and scanning electron microscopy. Qualitative micromorphological variations in shape of epidermal cells, anticlinal wall pattern, stomatal type and shape, stomatal pore shape, guard cells shape, and trichomes types were studied. In addition, some quantitative characters were also studied and data were statistically analyzed in epidermal cell size, stomatal size, stomatal pore size, stomatal density, and stomatal index. The pivotal result of study include; shape of epidermal cell in all species is irregular on both abaxial and adaxial surfaces. The anticlinal walls are sinuous in most of the species but some species have irregular lobed and broadly lobed wall. Leaves are hypostomatic in all studied species. Two main categories of stomatal type were found: polocytic and anomocytic. Unicellular nonglandular trichomes were observed in only one species Athyrium mackinnoni. The variation in foliar micromorphological characters between the genera and within the species was useful in identification and classification and have potential taxonomic significance for species differentiation. An identification key using micromorphological characters are provided to distinguish genera and species.