bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacodynamic interaction of cumin seeds (Cuminum cyminum L.) with glyburide in diabetes
Authors: Kaur Ginpreet , Upadhyay Nidhi , Tharappel Leo J Philip , Invally Mihir 
Published: July 2019

Abstract

Background and objective
The plethora of anti-diabetic agents available today has many side effects, especially on chronic usage. Hence, alternative approaches utilizing natural and synthetic agents are sought after. Cumin has been shown to be beneficial in treating diabetes. This study evaluates the anti-diabetic effect of cumin and glyburide in the streptozotocin induced diabetes model in rats, and investigates their pharmacodynamic interactions and its implication in diabetes.

Methodology
The phytoconstituents present in the ethanolic cumin seed extract were determined using appropriate analytical methods. After acute toxicity studies (OECD 2001), the anti-diabetic effect of the extract was evaluated in wistar rats. The rats were divided into five groups – Groups I and II served as the normal and diabetic control. Group III was the standard control (glyburide 5 mg/kg), while groups IV and V received the extract (600 mg/kg) and a combination of the extract (600 mg/kg) and glyburide (2.5 mg/kg; half dose). Biochemical parameters viz. plasma glucose and glycosylated haemoglobin, were measured periodically during the 28 day treatment. On the 28th day, oral glucose tolerance test, lipid profile, renal profile and histopathological evaluation were performed after completion of the study. To investigate the nature of herb-drug interaction, HPLC analysis for estimation of glyburide concentration in the blood was conducted.

Results
Acute toxicity studies showed the extract to be safe till a dose of 2 g/kg. The extract alone, and in combination with glyburide (half-dose), significantly lowered elevated glucose (by more than 45% from baseline; without producing hypoglycemia), and other lipid and renal parameters. The effects produced by 2.5 mg/kg glyburide, and 5 mg/kg glyburide (without extract) were similar. Histopathological analysis also showed that the extract was able to reverse the degeneration brought about by streptozotocin which was especially notable on the pancreatic and renal tissue. HPLC analysis revealed differing pharmacokinetics of glyburide in the groups treated with 5 mg/kg dose, and 2.5 mg/kg + 600 mg/kg extract.

Conclusion
The results obtained in this study suggest that Cuminum cyminum L. is a promising anti-diabetic agent, and exhibits pharmacodynamic interaction with glyburide to mitigate symptoms of diabetes mellitus.
Warionia saharae induces antihypertensive and vasorelaxant activities through nitric oxide and KATP channels pathways in rats
Authors: EL-Ouady Fadwa , Eddouks Mohamed 
Published: July 2019

Abstract

Background

Warionia saharae Bentham & Cosson. is used in traditional medicine to treat many diseases including hypertension.

Method
The present study was designed to investigate the antihypertensive activity of aqueous extract of Warionia saharae (WSLAE) in anesthetized L-NAME (Nω-L-arginine methyl ester)-induced rats. The acute and sub-chronic effects of WSLAE on systolic, diastolic, mean arterial blood pressure and heart rate (HR) were investigated after oral administration of the extract (100 mg/kg body weight of WSLAE) during 6 h for the acute experiment and during 7 days for the sub-chronic test. In addition the effect of WSLAE on the contractile response of isolated rat aortic rings was tested and the role of the vascular receptors was evaluated using several drugs.

Results
The results showed that WSLAE induced a significant decrease in the systolic, diastolic, mean arterial blood pressure and HR in both normotensive and hypertensive rats. Furthermore, this extract induced relaxation in rings pre-contracted with Epinephrine (10 µM) or with KCl (100 mM). This vasorelaxant capacity seems to be mediated through inhibition of KATP channels and nitric oxide (NO) synthase pathways.

Conclusion
This study supports the use of Warionia saharae in the management of hypertension in Moroccan traditional medicine.
Molybdenum and lanthanum as alternate burn-up monitors – development of chromatographic and mass spectrometric methods for determination of atom percent fission
Authors: Bera Suranjan , Sujatha Krishnamurthy , Sivaraman Nagarajan , Lakshmi Narasimhan Tiruppatur Subramaniam 
Published: July 2019

Abstract
A rapid high performance liquid chromatography (HPLC) and thermal ionisation mass spectrometric (TIMS) methods have been developed for the separation and estimation of fission product elements molybdenum and lanthanum for the burn-up measurements on the dissolver solution of Indian pressurised heavy water reactor (PHWR) spent fuel. Reverse phase chromatography method was developed to separate molybdenum from dissolver solution using mandelic acid as mobile phase and a dynamic ion exchange chromatography technique was used for the separation of lanthanum as well as neodymium from a dissolver solution. Sample loading methods which resulted in enhanced ionisation efficiency have been developed for the TIMS analysis of HPLC separated molybdenum and lanthanum fractions. Ascorbic acid mixed with silicic acid in HCl medium was used for loading the molybdenum on to a rhenium filament to obtain stable and intense ion beam. A novel sample loading method for lanthanum in which a mixture of graphite + boric acid (H3BO3) + silica gel was employed to achieve enhanced and steady ion beam formation of LaO+. Concentrations of species of interest were determined employing suitable spikes by isotope dilution mass spectrometry (IDMS) method. The developed methods were adopted for PHWR dissolver solution to establish molybdenum and lanthanum as alternate burn-up monitors. The burn-up data obtained were compared with the well established method of neodymium as fission product monitor. This is a first study of its kind where the data obtained by using molybdenum and lanthanum as fission product monitors were compared with that obtained by Nd-148 method.
Optical Properties of Liquid Crystalline Alkoxy Benzoic Acids with Dispersed Citrate-Capped Gold Nanoparticles
Authors: Tejaswi M. , Pardhasaradhi P. , Madhav B.T.P. , Pandian K. , Jayaprada P. , Manepalli R.K.N.R. , Pisipati V.G.K.M. 
Published: July 2019

Abstract
Citrate-capped gold nanoparticles (Gnps) have multiple applications in all optical devices and influence the properties of birefringence in liquid crystalline (LC) molecules. In the present paper, systematic studies have been carried out on LC compounds p-n-undecyloxy benzoic acid (11oba) and p-n-dodecyloxy benzoic acid (12oba) with dispersed citrate-capped Gnps in different low molar concentrations. The phase transition temperatures of the LC nanocomposites obtained from polarizing thermal microscopy (POM), differential scanning calorimetry (DSC) and modified spectrometry are found to be reduced with the increase in concentration of dispersed citrate-capped Gnps. The information was obtained from textural data utilizing the simple technique gradient measurement of standard deviation (GMSD) using the MATLAB tool, which is analogous to DSC. Further, the existence of citrate-capped Gnps in 11oba and 12oba was determined by spectroscopic techniques like ultraviolet-visible spectrometry and scanning electron microscopy. The birefringence measurements were carried out at different wavelengths (460, 500, 570 and 635 nm) using a wedge-shaped cell with a modified spectrometer. The birefringence (δ
n) increases with increase in weight concentration of citrate-capped Gnps in the nematic thermal range. Further, the order parameter S values obtained from the Kuczynski internal field model, the Vuks model, the Haller extrapolation model and the effective geometry parameter methods are in good agreement. It is found that the order parameter S increases with increase in dispersion of concentration of citrate-capped Gnps. This is due to strong Van der Waal’s interaction between the LC molecules and citrate-capped Gnps, which increases the alignment of the LC molecules.
Effect of Moisture on Full-Scale Pavement Distress
Authors: Camacho-Garita Edgar , Aguiar-Moya J. P. , Ávila-Esquivel T. , Loría-Salazar L. G. 
Published: July 2019

Abstract
The effect of moisture is fundamental in determining pavement responses. It becomes more important in tropical regions where high precipitation rates and high variability in water table levels are present. The results indicate that when comparing the quantitative performance of pavement sections that are subjected to near saturation conditions, the bearing capacity of the pavement structure can be as low as 5 % of that associated to the same structure but with optimum water content. The damage in the saturated pavement sections is greatly accelerated because of pumping of fines from the subgrade and the subbase. All the pavement layers are affected by loading (decrease or increase in layer moduli) but to a different degree depending on the moisture conditions. Furthermore, the effect of moisture is greater in the cohesive soils and contaminated granular materials. Finally, the relatively stiffer layers (i.e., hot mix asphalt and cement-treated base layers) are the ones that are more susceptible to a higher deterioration rate, particularly under saturated or near saturated conditions.
The Application of Quantum Learning Interactive Multimedia Assisted Learning Model towards the Student’s Learning Outcomes in Animalia Material
Authors: Afniyati Nur , Yuniastuti Ari , Subekti Niken 
Published: July 2019

Observation was done to biology teachers and students in MAN 2 Semarang, so that students have not experienced difficulty of learning the Animalia material. The less of media and facilities make students' motivation low, so it impacts on learning outcomes. The classical completeness average of daily tests on the material value of invertebrates is less than 60% with a minimum completeness criteria (KKM) is 75. The model can be used in providing an understanding of Animalia matter is learning Quantum Learning. The Quantum Learning is learning to use a syntax TANDUR (Tandur/Grow, Alami/Natural, Namai/ Name, Demonstrasikan/Demonstrate, Ulangi/Repeat, Rayakan/Celebrate).
The research was conducted in MAN 2 Semarang with the research method used Pre-Eperimental, One Shot Case Study. The research design used in this research is quantitative 1q. The research steps include making proposals and instruments, testing trial and feasibility, instrument validation, application of learning method and end data processing. The results are cognitive and psychomotor learning outcomes. The cognitive learning outcomes showed the classical completeness of experimental class 95% and 90%, the average value of class X IPA 1 85 and 80. Psychomotor learning outcomes showed the experimental class average 82 and 81 with good criteria. Based on the data obtained indicates that the method applied is effective to maximize the learning outcomes. The learning outcome is effective when classical learning completeness reached ≥75% of the total and ≥75% for psychomotor aspect. Therefore, according to the results of this study, it can be concluded that the application of Quantum Learning- assisted Interactive Multimedia learning model towards student’s learning outcomes in Animalia material on SMA / MA and teachers give a positive response to the applied learning. Further, it can be imlied that Quantum Learning-assisted interactive multimedia learning model effect on student learning outcomes.
***[RETRACTED]*** Effectiveness of Ferro Sulfate Supplementation on Hemoglobin and Ferritin Levels of Trimester I Pregnant Women
Authors: Isfaizah Isfaizah , Cahyaningrum Cahyaningrum 
Published: July 2019

RETRACTION TO:
Isfaizah & Cahyaningrum. 2019. Effectiveness of Ferro Sulfate Supplementation on Hemoglobin and Ferritin Levels of Trimester I Pregnant Women. Unnes Journal of Public Health, 8(1): 51-56.

This article has been retracted by Publisher based on the following reason:
It is reported that this article has been published in Jurnal Medika Respati Volume 13 Issue 3, 2018 [http://medika.respati.ac.id/index.php/Medika/article/view/174/165].
Based on clarification, authors of the above paper have admitted submitting this paper to the both journals which it is forbidden and already explained explicitly in submission form of Unnes Journal of Public Health.

One of the conditions of submission of a paper for publication in this journal is that authors declare explicitly that their work is original and has not appeared in a publication elsewhere. As such this article represents a severe abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.
Plasma exchange and early thyroidectomy in thyroid storm requiring extracorporeal membrane oxygenation
Authors: Koh Huilin , Kaushik Manish , Loh Julian Kenrick , Chng Chiaw Ling 
Published: July 2019

Summary
Thyroid storm with multi-organ failure limits the use of conventional treatment. A 44-year-old male presented with thyroid storm and experienced cardiovascular collapse after beta-blocker administration, with resultant fulminant multi-organ failure requiring inotropic support, mechanical ventilation, extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy. Hepatic and renal failure precluded the use of conventional thyroid storm treatment and early plasma exchange was instituted. The patient underwent emergency thyroidectomy after four effective exchanges, with subsequent rapid reversal of multi-organ failure. The challenges of institution of plasma exchanges with ongoing ECMO support, dialysis and timing of thyroidectomy are discussed. This case highlights the important role of early therapeutic plasma exchange (TPE) as an effective salvage therapy for lowering circulating hormones and stabilization of patients in preparation for emergency thyroidectomy in patients with thyroid storm and fulminant multi-organ failure.

Learning points:

Administration of beta-blockers in thyroid storm presenting with congestive cardiac failure may precipitate cardiovascular collapse due to inhibition of thyroid-induced hyperadrenergic compensation which maintains cardiac output.

TPE can be an effective bridging therapy to emergency total thyroidectomy when conventional thyroid storm treatment is contraindicated.

End-organ support using ECMO and CRRT can be combined with TPE effectively in the management of critically ill cases of thyroid storm.

The effectiveness of plasma exchange in lowering thyroid hormones appears to wane after 44–48 h of therapy in this case, highlighting the importance early thyroidectomy.
Unidades Productivas Integrales, como un producto Turístico para el Desarrollo Rural Sustentable
Authors: Montero-Herrera Sonia Lucía 
Published: July 2019

Las Unidades Productivas Integrales (UPI), son un sistema de producción que permite el uso óptimo de los recursos naturales y culturales, por medio del manejo de tecnologías de bajo costo, que promueven un desarrollo endógeno y auto sostenible y alta diversidad de productos agropecuarios, forestales y energéticos de origen local o adaptados al territorio.
Se caracterizan por ocupar mano de obra familiar, productos orgánicos de origen autóctono, comercializables y encadenables al producto turístico local. Su importancia, radica en que proporcionan, seguridad alimentaria, manejo integrado de los recursos, protección del medio ambiente, formación de microempresas y organización comunitaria. Por esta razón la Universidad Nacional de Costa Rica (UNA) con sus proyectos de extensión universitaria, acompañan a estas comunidades indígenas en la implementación de estas unidades. Como proyecto denominado: Autogestión y sostenibilidad de las unidades productivas en territorios indígenas del Valle la Estrella, con miras a la consolidación de un sistema de producción basado en una cosmovisión indígena e intercambio de saberes ancestrales en el Territorio Indígena Tayni, en el Valle de la Estrella, Limón, Costa Rica; el cual con técnicas participativas que tienden a favorecer el intercambio de saberes ancestrales como instrumento de aprendizaje. En este territorio la UNA ha logrado replicar el modelo de las UPI, en todos los centros educativos en torno a la primera iniciativa creada en el 2015, permitiendo la diversificación de los productos alimentarios en comedores estudiantiles locales y en la comunidad y en general, el rescate de productos medicinales tradicionales del bosque, y de la cultura local. El proyecto ha generado empoderamiento local y ha creado la necesidad de incursionar en iniciativas de turismo rural comunitario, enfocado en los saberes ancestrales locales. Asociado con la motivación de los estudiantes de los centros educativos para ingresar en un futuro a la UNA, donde actualmente hay cinco estudiantes de este territorio de los cuales cuatro ya están por graduarse en las diferentes carreras del campus Sarapiquí.
Permaculture demonstration sites in Central America: contributions to agroecological transition and implications for educators
Authors: Conz Brian W. 
Published: July 2019

Central America has been an important region for the agroecological revolution, building on a history of intensive smallholder farming practices, farmer-to-farmer knowledge sharing and agrarian social movements. Permaculture is an approach to ecological site design and agroecological transition, which has grown in popularity in Central America in recent years. Permaculture’s entrance into the larger movement for agroecology in Central America raises some important questions. How does permaculture intersect with these existing forces? How can permaculturalists address perceptions that it is yet another colonialist development intervention by well-meaning Northerners? What are the implications for educators who visit permaculture demonstration sites with students? In order to explore these questions and to contribute to discussions regarding permaculture’s contribution to agroecological transition in Central America I visited two permaculture demonstration sites and participated in site tours. I discussed site features with farmers and gathered information from farm websites. I bring these experiences into conversation with the academic literature on agroecology and permaculture. I conclude that permaculture sites make valuable contributions to agroecological transition in Central America. I also identify important risks that sustainability educators using permaculture demonstrations sites should be aware of and I offer suggestions for addressing these risks.
Ordenamiento en disputa y espacialización de la injusticia en Colombia
Authors: Velez-Torres Irene , Pérez-Pérez José Joaquín , Riascos-Riascos Diver Antonio 
Published: July 2019

Este artículo analiza las relaciones entre ordenamiento territorial y reconocimiento étnico a partir de las experiencias de dos comunidades afrodescendientes localizadas en el valle plano del río Cauca, Colombia: El Hormiguero y El Tiple. Se ilustran las tensiones del Estado colombiano, surgidas entre el reconocimiento diferenciado de derechos a las poblaciones étnicas y los mecanismos para ordenar el uso y la apropiación de la naturaleza. La metodología empleada tuvo un enfoque cualitativo de tipo etnográfico y archivístico, donde se privilegió la interacción con las comunidades organizadas en torno a los Consejos Comunitarios y la revisión del extenso archivo normativo que sustenta el ordenamiento territorial municipal. El análisis comparativo de los casos de El Hormiguero y El Tiple demuestra una forma institucionalizada de injusticia espacial dada la imposición de facto de intereses económicos privados sobre el ordenamiento de los territorios. Injusticia que ha privado a las comunidades afrodescendientes de los derechos étnicos adquiridos, como el reconocimiento, el territorio y la consulta previa, libre e informada.Ideas destacadas: artículo de investigación sobre el confinamiento de las comunidades afrodescendientes en el valle plano del río Cauca que implica injusticia en cuanto a la distribución de la propiedad y del uso del suelo. La segmentación espacial causada por la expansión de la caña de azúcar ha sido instituida por instrumentos de planificación territorial, incluso negando derechos constitucionales de estas comunidades.
Protagonismo das mulheres assentadas no Território Rural do Bolsão-ms: gênero, território e resistência camponesa
Authors: Vilela Borzone Clariana , Aparecida de Almeida Rosemeire 
Published: July 2019

O Território Rural do Bolsão, área que compreende oito municípios na região leste de Mato Grosso do Sul, Brasil, tem sido palco da expansão dos monocultivos de eucalipto, acirrando as disputas territoriais entreo campesinato e a agricultura capitalista. As mulheres que residem nos assentamentos de reforma agráriainstalados nessa área têm protagonizado importantes ações para a construção da resistência camponesa. Para melhor compreensão desse protagonismo, buscou-se dar visibilidade às questões de gênero desenvolvidas no campo. A pesquisa foi feita por meio de levantamento de referencial teórico, coleta de dados, trabalhos decampo e entrevistas feitas com 23 mulheres de cinco assentamentos. Revelaram-se o aumento da participação feminina na esfera pública, bem como mudanças na divisão sexual de tarefas no âmbito privado. Tais mudançasdialogam com os debates da agroecologia e da soberania alimentar, e destacam a importância do esforçofeminista entremeado às questões de luta e permanência na terra no contexto neoliberal atual. Ideias destacadas: artigo de investigação sobre o protagonismo das mulheres dos assentamentos da reforma agrária na construção da resistência camponesa, no contexto da expansão de monocultivos, analisados por meio de levantamento de dados estatísticos e entrevistas com mulheres de cinco assentamentos do Território Rural do Bolsão, Mato Grosso do Sul, Brasil.
Enthalpies of formation of the solid solutions of ZrxY0.5−x/2Ta0.5−x/2O2 (0 ≤ x ≤ 0.2 and 0.65 ≤ x ≤ 1)
Authors: Lepple Maren , Lilova Kristina , Levi Carlos G. , Navrotsky Alexandra 
Published: July 2019

Abstract