bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respiratory Outcomes of Interrupted Modulator Therapies in Children With Cystic Fibrosis
Authors: Oztosun Berrak , Baskan Azer Kilic , Arslan Huseyin , Korkmaz Cigdem , Collak Abdulhamit , Cokugras Haluk , Sakalli Ayse Ayzit Kilinc 
Published: November 2024

ABSTRACTBackgroundCystic fibrosis (CF) is a multisystemic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective synthesis or function of the CFTR protein. Historically, CF treatment focused on managing symptoms and complications. Fortunately, modulator drugs are now available to directly target the defective CFTR protein. However, in some countries, such as Turkey, these drugs are not covered by social insurance. Consequently, many CF patients face barriers to accessing modulatory therapies or must interrupt their treatment. This study demonstrates the impact of interrupting modulator therapy on pulmonary function, emphasizing the need for uninterrupted continuous treatment.MethodsIn this study, 39 CF patients receiving elexacaftor‐tezacaftor‐ivacaftor (ETI) at our clinic were retrospectively analyzed. Among the patients, 18 experienced one or more interruptions, ranging from 15 to 210 days during ETI treatment. We analyzed pulmonary function test results from 27 interruption periods.ResultsAt the beginning of the interruption, the mean percent predicted FEV1 (ppFEV1) was 69.59% ± 25.87%, which decreased to 64.96% ± 24.52% by the end of the interruption. There was a significant decrease with a mean change of 4.62 ± 8.49 (p = 0.008). However, no significant correlation was found between the interruption duration and FEV1 change.ConclusionOur results demonstrate that pulmonary functions are adversely affected by interruption periods, regardless of their duration. Even short interruptions have a significant impact on pulmonary functions. This underscores the need for uninterrupted continuation of modulatory treatment and for improved policies to ensure equitable access to treatment.
Multidimensional Quantum Generative Modeling by Quantum Hartley Transform
Authors: Wu Hsin‐Yu , Elfving Vincent E. , Kyriienko Oleksandr 
Published: November 2024

AbstractAn approach for building quantum models based on the exponentially growing orthonormal basis of Hartley kernel functions is developed. First, a differentiable Hartley feature map parameterized by real‐valued argument that enables quantum models suitable for solving stochastic differential equations and regression problems is designed. Unlike the naturally complex Fourier encoding, the proposed Hartley feature map circuit leads to quantum states with real‐valued amplitudes, introducing an inductive bias and natural regularization. Next, a quantum Hartley transform circuit is proposed as a map between computational and Hartley basis. The developed paradigm is applied to generative modeling from solutions of stochastic differential equations, and utilize the quantum Hartley transform for fine sampling from parameterized distributions through an extended register. Finally, the capability of multivariate quantum generative modeling is demonstrated for both correlated and uncorrelated distributions. As a result, the developed quantum Hartley‐based generative models (QHGMs) offer a distinct quantum approach to generative AI at increasing scale.
Viability of Phytoplankton, Zooplankton, and Aquatic Macroinvertebrates in Dredged River Sediments of the Upper Mississippi River
Authors: Vander Vorste Ross , Strassman Sara , Henkhaus Sarah 
Published: November 2024

ABSTRACTSediment dredging is widely used to manage freshwater ecosystems, including maintaining river navigation corridors. Beneficial uses of the sediments are needed to reduce demands on new and existing stockpile sites. However, using dredged sediments in waterbodies outside the sediment source poses an ecological risk if aquatic organisms remain viable through desiccation‐resistant forms. We assessed viability of aquatic organisms in dredged river sediments from four locations along the Upper Mississippi River. We artificially re‐inundated sediments that had been dry for < 1, 1–5, and 5–10 years and sampled phytoplankton, zooplankton, and macroinvertebrate for 4 weeks. We hypothesized that richness and density of aquatic organisms would be negatively affected by duration of drying. Although individual samples of the most recently dredged material had the greatest richness and density of phytoplankton, zooplankton, and macroinvertebrates, mean richness and density was not different across sediment drying durations. Overall, richness and density of aquatic organisms was low in relation to in situ sampling especially following the first week of sediment re‐inundation. Our results suggest transporting sediments from main channel navigation dredging from the Upper Mississippi River to support beneficial uses in other waterbodies poses some ecological risk given our observations of viable organisms in dredged sediments. We present a multistep risk evaluation procedure that could be applied when considering beneficial uses for dredged sediments.
Depth Profiles of Crystallinity and Preferential Orientation and Surface Characteristics of Sputter‐Deposited CeO2 Thin Film Buffer Layers on Sapphire Substrates Evaluated Through Two‐Dimensional Grazing‐Incidence X‐Ray Diffraction
Authors: Fukano Tatsuo , Nozaki Hiroshi , Funayama Keita , Katsuno Takashi , Koganezawa Tomoyuki , Harada Masashi , Kawaura Hiroyuki 
Published: November 2024

ABSTRACTTwo‐dimensional grazing‐incidence wide‐angle X‐ray diffraction data were acquired from CeO2 thin films serving as buffer layers on r‐cut sapphire substrates to investigate the depth profiles of crystallinity and preferential orientation as well as surface conditions. The thin film samples were sputter‐deposited under different conditions. Data were obtained at an X‐ray wavelength of 0.100 nm at 0.02° intervals from 0.06° to 0.30° at the grazing‐incidence angle. A 60‐nm‐thick CeO2 thin film sputter‐deposited under Ar (Ar‐60) and a 100‐nm‐thick CeO2 thin film sputter deposited using 10 vol.% O2 in Ar (O+Ar‐100) were found to have partially oriented three‐dimensional bulk crystal structures with preferential orientation in the (100) direction near the surface. The lattice constant for the Ar‐60 film was found to be approximately 0.30% smaller than that for a CeO2 standard, whereas the lattice constant for the O+Ar‐100 film was approximately 0.50% larger. Lattice mismatch between the CeO and CeO2 on the substrate surface is evidently not an issue based on the lattice constants near the surface. Hence, both films could be considered to represent optimal buffer layers for YBa2Cu3O6+δ thin film growth. However, even in the case of a CeO2 thin film suitable for use as a buffer layer, the difference in lattice constants between the interior and surface of an Ar‐60 film was found to be relatively small, whereas that for an O+Ar‐100 film was relatively large. These results show that it is important to analyze the film surface in detail by reducing the incidence angle to less than 0.1°.
A General Framework for the Multiple Nonparametric Behrens–Fisher Problem With Dependent Replicates
Authors: Sprünken Erin , Mertens Robert , Konietschke Frank 
Published: November 2024

ABSTRACTIn many trials and experiments, subjects are not only observed once but multiple times, resulting in a cluster of possibly correlated observations (e.g., brain regions per patient). Observations often do not fulfill model assumptions of mixed models and require the use of nonparametric methods. In this article, we develop and present a purely nonparametric rank‐based procedure that flexibly allows the unbiased and consistent estimation of the Wilcoxon–Mann–Whitney effect in clustered data designs. Compared with existing methods, we allow flexible weights to be used in effect estimation. Additionally, we develop global and multiple contrast test procedures to test null hypotheses formulated regarding the generalized Mann–Whitney effects and for the computation of range‐preserving simultaneous confidence intervals in a unified way. Extensive simulation studies show that these methods control the type‐I error rate well and have reasonable power to detect alternatives in various situations.
Chitosan Nanoparticles as a Potential Drug Delivery System in the Skin: A Systematic Review Based on In Vivo Studies
Authors: Santana Gomes Amanda , Silva Simplicio Sidney , Marinheiro da Cunha Gonsalves Joyce Kelly 
Published: November 2024

AbstractChitosan nanoparticles (ChNP) represent an interesting technological platform for drug delivery to the skin due to their mucoadhesive, nontoxic, and biodegradable characteristics, offering advantages in bypassing the stratum corneum and improving drug delivery in dermal administration. This systematic review analyzed the in vivo applicability of ChNP as a substance delivery system to the skin. A literature search was conducted in the databases PubMed, SciELO, and Lilacs using the keywords “nanoparticle,” “chitosan,” and “skin.” Inclusion criteria involved in vivo studies investigating the effects of topical use of these nanoparticles, published between 2013 and 2023, and comparing the nanoparticulate formulation with the free drug. The prevalence of studies conducted on animal models was 94.1%, while only 5.9% were performed on humans. The results suggest that ChNP formulations improved the delivery of therapeutic agents and demonstrated superior efficacy compared to formulations containing the free drug; they exhibited good permeability and tolerability, gradual release of the active molecule, and faster results with minimal adverse effects. Therefore, ChNP containing active substances for topical application emerges as a safe and effective platform with significant potential for drug delivery to the skin, opening new perspectives for their use in innovative formulations.
Gas‐Phase Photocatalytic Degradation of a Mixture of VOCs on Ag NPs Decorated ZnO
Authors: Nakhostin Panahi Parvaneh , Alimohammadi Soheila , Norouzi Fatemeh 
Published: November 2024

AbstractIn this research, silver was loaded onto ZnO using the photoreduction method to enhance the photocatalytic activity of ZnO in the visible region. The photocatalytic activity of ZnO and Ag/ZnO was investigated for the gas‐phase degradation of volatile organic compounds such as ethyl acetate, ethanol, and toluene under visible light irradiation. The Ag/ZnO effectively decomposed ethyl acetate, toluene, and ethanol separately and in a mixed state. The characteristics of Ag/ZnO and ZnO were studied using XRD, SEM, EDAX, XPS, BET, UV–vis DRS, and PL analyses. The XRD pattern confirmed the formation of metallic silver in the Ag/ZnO photocatalyst. The PL results showed that the loading of Ag on the ZnO significantly reduces the photoelectron‐hole pairs recombination in Ag/ZnO.
Biomimetic Nano‐delivery of Small‐Molecule Piceatannol Modulates Tumor Stemness and Suppresses Colorectal Cancer Metastasis via Hippo/YAP1/SOX9 Signaling
Authors: Zhou Minfeng , Niu Huifang , Huang Guoquan , Zhou Minquan , Cui Dandan , Li Huarong , Wen Han , Zhang Hongxing , Liang Fengxia , Chen Rui 
Published: November 2024

AbstractSuppressing tumor metastasis is a crucial strategy for improving survival rates in patients with colorectal cancer (CRC), with cancer stem cells (CSCs) being the primary drivers of metastasis. Current therapeutic approaches targeting CSCs are limited, and their molecular mechanisms remain unclear. To address this challenge, a biomimetic nanoparticle delivery system, CMD‐BHQ3‐PTL/DOX@RBCM is developed, to deliver the stem cell regulator, piceatannol (PTL). This system used carboxymethyl dextran (CMD) and Black Hole Quencher 3 (BHQ3) to encapsulate PTL and the cytotoxic drug doxorubicin (DOX) within a red blood cell membrane (RBCm), enhancing stability and biocompatibility while allowing gradual drug release under hypoxic conditions. The effects of PTL are investigated on CSCs using molecular biology experiments, plasmid construction, and high‐throughput sequencing and elucidated the molecular mechanisms underlying this biomimetic nanoparticle delivery system. The therapeutic efficacy of PTL is validated at the tissue level using subcutaneous and metastatic tumor models in human and murine systems. The results demonstrated that CMD‐BHQ3‐PTL/DOX@RBCM effectively addressed the challenges of specificity and biocompatibility in vivo, significantly inhibiting CSC‐related tumor metastasis. This inhibitory effect is closely associated with the Hippo/YAP1/SOX9 pathway. This study highlights the effectiveness of the pH‐responsive biomimetic nanoparticle system CMD‐BHQ3‐PTL/DOX@RBCm in delivering PTL to tumor sites, with SOX9 and its upstream Hippo/YAP1 pathway playing a critical role in the underlying mechanism.
Exploring Biomineralization Processes Using In Situ Liquid Transmission Electron Microscopy: A Review
Authors: DiCecco Liza‐Anastasia , Tang Tengteng , Sone Eli D. , Grandfield Kathryn 
Published: November 2024

AbstractLiquid transmission electron microscopy (TEM) is a newly established technique broadly used to study reactions in situ. Since its emergence, complex and multifaceted biomineralization processes have been revealed with real‐time resolution, where classical and non‐classical mineralization pathways have been dynamically observed primarily for Ca and Fe‐based mineral systems in situ. For years, classical crystallization pathways have dominated theories on biomineralization progression despite observations of non‐traditional routes involving precursor phases using traditional‐ and cryo‐TEM. The new dynamic lens provided by liquid TEM is a key correlate to techniques limited to time‐stamped, static observations – helping shift paradigms in biomineralization toward non‐classical theories with dynamic mechanistic visualization. Liquid TEM provides new insights into fundamental biomineralization processes and essential physiological and pathological processes for a wide range of organisms. This review critically reviews a summary of recent in situ liquid TEM research related to the biomineralization field. Key liquid TEM preparation and imaging parameters are provided as a foundation for researchers while technical challenges are discussed. In future, the expansion of liquid TEM research in the biomineralization field will lead to transformative discoveries, providing complementary dynamic insights into biological systems.
Tensor Landmark Analysis With Application to ADNI data
Authors: Park Sung Hee , Zhou Ruiwen , Zhang Xin , Li Liang , Liu Lei 
Published: November 2024

ABSTRACTRecent advancements in data collection have facilitated the use of multidimensional arrays, also known as tensors, in prediction of health outcomes. In this article, we introduce a tensor landmark model for predicting survival outcomes using multiple longitudinal biomarkers as tensor covariates through CANDECOMP/PARAFAC (CP) decomposition. An iteratively reweighted least squares estimation is adopted for components of the tensor coefficients in the landmark model. We also present empirical results of the Akaike information criterion (AIC) and the Bayesian information criterion (BIC) for right‐censored data to select the CP rank. Simulations and Alzheimer's disease neuroimaging initiative (ADNI) data analysis demonstrate that our proposed model accurately estimates survival coefficients and predicts survival probabilities. The implementation code can be found online (https://github.com/sparkqkr/TensorCoxReg).
Multigranularity Coverage Criteria for Deep Learning Libraries
Authors: Shi Ying , Zheng Zheng , Yin Beibei , Xi Zhiyu 
Published: November 2024

ABSTRACTDeep learning (DL) systems are becoming increasingly widely used in safety domains such as self‐driving cars and unmanned aerial vehicles, which arouse natural concerns about their trustworthiness. Underlying DL libraries used in the construction and execution of DL models are involved in the testing processes of DL systems. Therefore, bugs in DL libraries can inevitably cause unexpected behaviours in DL systems. The internal structures of DL libraries are described as APIs with different functionalities, and DL libraries offer model developers access to DL techniques with various API parameter settings. The above characteristics of DL libraries reveal that existing DL coverage criteria are not designed specifically for DL libraries, and traditional software coverage criteria do not apply to DL libraries either. The paper introduces the first set of coverage criteria specifically designed for the systematic measurement of DL libraries across various granularities. APIs, as the fundamental components of DL libraries, are used to define coverage criteria gauging testing adequacy by thoroughly considering their invocation, implementation, parameter quantities and parameter attributes. Furthermore, some properties depicting relations between coverage criteria are investigated. Experiments on the effectiveness of the proposed coverage criteria and comparative analysis are conducted by interval estimate and hypothesis testing techniques for APIs in two well‐known DL libraries. The experimental results demonstrate that the proposed coverage criteria are effective in measuring the test adequacy of DL libraries, and they can be used for the quantitative analysis of test model quality in DL libraries.
A New Contribution Confirming the Analogy Between NO+ and Related Aryldiazo Ligands
Authors: Rösch Markus , Klapötke Thomas M. , Böttcher Hans‐Christian 
Published: November 2024

AbstractThe reaction of the cyclometalated five‐coordinate 16 electron iridium(III) complex [IrCl(H){P(tBu)2C6H4–κ2P,C}{P(tBu)2Ph}] (1) with the diazonium salt [p‐BrC6H4N2]BF4 in dichloromethane at room temperature was investigated. By spontaneous reductive elimination the iridium(I) complex salt trans‐[IrCl(N2C6H4Br‐p){(P(tBu)2)Ph}2]BF4 (2) was obtained in good yield. Therefore, this observed reaction behavior exhibits the diazonium unit as a strong π‐acceptor group and confirms furthermore the analogy between nitrosyl and aryldiazonium ligands. The new compound 2 has been characterized by standard spectroscopic methods and the molecular structure of 2 was determined by a single‐crystal X‐ray diffraction analysis (monoclinic, space group Cc, Z=4).
Automatic Imitation of Multiple Agents
Authors: Cracco Emiel 
Published: November 2024

Abstract
Despite the vast and growing literature on automatic imitation, only little is known about automatic imitation in situations with multiple agents. Instead, the large majority of research focuses on dyadic interactions, where one person interacts with a single other person. This is surprising, because such dyadic interactions make up only a small part of social life. In this chapter, I will summarize recent research on automatic imitation beyond the dyad. More specifically, I will discuss four questions: Does automatic imitation change as a function of group size? What happens when individuals in the group perform different or conflicting actions? What is the mechanism underlying automatic imitation of multiple agents? And does being part of a group change automatic imitation of groups? Overall, the evidence converges on the idea that imitation is simultaneously informed by the different agents in our surrounding. However, many questions still remain, and answering them will be key to better understand the processes underlying automatic imitation in more complex social settings.
Social Modulation of Imitative Behavior
Authors: Genschow Oliver , Cracco Emiel 
Published: November 2024

Abstract
Given that imitative behavior is a social phenomenon, an often put forward claim in the literature is that imitation should be modulated by social factors. Motivational theories explain social modulation with the notion that people use imitation as a tool to affiliate with others. As a result, individuals are expected to imitate others more when they have an affiliation goal. Self-other overlap theories suggest that imitative tendencies are learned responses that develop as a result of self-observation and interaction with other, often similar individuals. As a consequence, imitation is expected to increase if perceived similarity is high. Interestingly, the empirical evidence for these theories has been rather mixed. That is, while there is cumulative evidence for the influence of some social factors, there is only preliminary or no evidence for the influence of other social factors. In this chapter, we review the evidence in favor and against social modulation of imitative behavior, explain why some, but not other factors influence imitation, and then end with outlining potential avenues for future research.
The Benefits—and Costs—of Behavioral Mimicry: Applications in Marketing, Sales, and Therapy
Authors: Kulesza Wojciech , Chartrand Tanya 
Published: November 2024

Abstract
Previous research on the so-called Chameleon effect and other studies on more general mimicry indicate that mimicking another person’s gestures, mannerisms, and speech (whether intentionally or not) leads to several profound social consequences without awareness that mimicry took place (Chartrand and Bargh, J Personality Soc Psychol 76:893–910, 1999). This chapter reviews research on mimicry as a nonconsciously employed mechanism by focusing on the consequences of mimicry. Thereby, we will review positive as well as negative consequences that take place within and beyond the mimicry dyad.
Automatic Imitation and the Correspondence Problem of Imitation: A Brief Historical Overview of Theoretical Positions
Authors: Brass Marcel 
Published: November 2024

Abstract
The main aim of the current chapter is to situate automatic imitation in the broader historical context of research on the functional mechanisms underlying imitation. Intuitively, imitation is a very simple act: you do what you see. However, on closer inspection, the question arises as to how a perceptual representation of a movement can be transformed into a corresponding motor program (the so-called correspondence problem of imitation). Research on the correspondence problem has a long history in psychology. Three major theoretical approaches to solve the problem have been proposed: first, imitation has been conceptualized as an innate mechanism; second, from a learning theoretical perspective, imitation has been understood as the result of simple learning mechanism, equating imitation with any other learned behaviour. Finally, ideomotor theory has conceptualized imitation as the result of ideomotor learning distinguishing it from other learned behaviour. While automatic imitation was originally developed in the context of ideomotor theory, it has also been used to support learning theoretical approaches to the correspondence problem. Almost 25 years of research on automatic imitation have not solved the correspondence problem but have provided cognitive psychology with a valuable tool to experimentally investigate imitative behaviour and to bridge the gap between cognitive and social-psychological approaches to imitation.