bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFICACY OF MYOCARDIAL REVASCULARIZATION IN POTENTIAL RECIPIENTS OF HEART WITH THE CHRONIC ISCHEMIC HEART FAILURE
Authors: Gautier S. V. , Mironkov A. B. , Sakhovsky S. A. , Koloskova N. N. , Muminov I. I. , Spirina E. A. , Tunyaeva I. Yu. , Mironkov B. L. 
Published: April 2018

Aim: to evaluate clinical effi ciency of percutaneous coronary interventions (PCI) at potential recipients of heart with the chronic ischemic heart failure (CHF).Materials and methods. In this retrospective study results of treatment at 76 patients with CHF NYHA III and 36 patients with CHF NYHA IV by scheduled PCI are presented. Duration of observation was from 6 to 160 months. The age of patients at the time of intervention was 61,7 ± 0,62 years (from 33 to 76). 108 male and 4 female. Defi ned life expectancy and echocardiography parameters of the left ventricle (LV) of heart. Results.20 patients were died, 16 of them from cardiovascular events. 18 patients during this period undergo orthotopic heart transplantation (HT). The endovascular revascularization leads to LV volumes reduction, increase of ejection fraction and decrease of pulmonary artery pressure. Progress CHF is followed by negative dynamics of these characteristics and need of HT performance. In 74% of cases the effect of myocardial revascularization allows to provide increase in life expectancy of potential recipients of heart with the chronic ischemic heart failure. Conclusion.Performance of PCI at patients with the chronic ischemic heart failure can delay heart transplantation or become its alternative.
OF PHOTOPHERESIS IN KIDNEY TRANSPLANTATION
Authors: Faenko A. P. , Zulkarnayev A. B. , Chuksina Ju. Ju. , Fedulkina V. A. , Kantaria R. O. , Kildyushevskiy A. V. , Vatazin A. V. 
Published: April 2018

Aim– to perform a comparative study of the long-term results of the combined use of extracorporeal photochemotherapy (photopheresis) and drug immunosuppression and standard immunosuppressive therapy in patients after kidney transplantation.Materials and methods. An open cohort randomized study was conducted, including 60 patients with chronic kidney disease stage 5D. All patients underwent single-group cadaveric kidney transplantation. Patients were randomly divided into two groups. All transplants were paired, the fi rst kidney transplant was received by the patient of the main group, the second – by comparison group. 30 patients of the main group received standard protocol of immunosuppression and 10–15 sessions of photopheresis during the fi rst six months after transplantation. All patients of the comparison group received standard immunosuppressive therapy only. End points: primary – graft loss, surrogate – the number of acute rejection episodes and infectious complications, the dynamics of creatinine blood concentration, the glomerular fi ltration rate and daily proteinuria, the dynamics of tacrolimus C0 blood concentration. To study the mechanism of photopheresis action in the late postoperative period, we evaluated the immunological parameters: subpopulation of naive T-cells (CD3+CD4+CD45RO–CD28+), the level of CD28 molecule expression (MFI) on these cells and also – subpopulation of T-regulatory cells (CD3+CD4+CD25 (Hi)CD127–).Results.The use of photopheresis leads to the graft function improvement in the late postoperative period: the creatinine concentration (p = 0.017) in the blood and daily proteinuria (p = 0.011) were lower in patients of the main group, the glomerular fi ltration rate was higher (p = 0.027). The incidence rate ratio (IRR) of rejection in the main group was signifi cantly lower than in the comparison group: 0.2509 (95% CI 0.05386, 0.9167), p = 0.0358. The risk of graft loss was also lower in the main group: IRR 0.2782 (95% CI 0.07562, 0.8657), p = 0.026, as well as the risk of infectious complications: IRR 0.3888 (95% CI 0.2754; 0, 5445), p < 0.0001. Survival rate of transplants was higher in the main group (Log Rank p = 0.009; Breslow p = 0.005). The use of photopheresis made it possible to reduce the concentration of tacrolimus in the late postoperative period (p = 0.0017) without increasing the risk of graft rejection. The photopheresis tolerogenic effect in the late postoperative period may be due to an increase in the population of T-regulatory cells with the CD3+CD4+CD25(Hi)+CD127– phenotype compared to the patients which received only standard immunosuppressive therapy (p = 0.024).Conclusion.The preventive use of photopheresis contributes to improvement of the kidney transplantation long-term outcomes. Further studies are needed to study the mechanisms of photopheresis action and markers of partial immunological tolerance to the allograft.
LIVER TRANSPLANTATION FROM SEXAGENARIAN AND OLDER
Authors: Gautier S. V. , Kornilov М. N. , Miloserdov I. A. , Minina M. G. , Kruglov D. N. , Zubenko S. I. 
Published: April 2018

Donor organs shortage leads to extending criteria for deceased liver donation in the whole world.Aim:to compare results of deceased donor liver transplantation (DDLT) depending of donor age over 60 years old.Materials and methods:the study includes 390 DDLT from January 2010 to November 2017. All liver donors separated by age for two groups: I – 60 years and older (n = 26); II – younger than 60 years (n = 364). All donors were standardized by demographic, laboratory fi ndings and inotropic drug requirement. Results:no difference between both groups in severity of ischemia-reperfusion injury, ICU or in-hospital staying (median 2 and 7,5 days respectively) was found. There is also no difference between biliary or vascular complication rate. 5-year actuarial survival rate found no difference between both groups (I: 70%: II: 76%, p = 0,54).Conclusion.Using grafts from donors older than 60 years don’t worsen early and late results of DDLT. Care should be taken to avoid other risk factors (cold ischemia time, warm ischemia time).
CULTIVATION OF HUMAN LIVER CELLS AND ADIPOSE-DERIVED MESENCHYMAL STROMAL CELLS IN PERFUSION BIOREACTOR
Authors: Basok Yu. В. , Grigoryev A. M. , Kirsanova L. A. , Shmerko N. P. , Khizroev К. M. , Sevastianov V. I. 
Published: April 2018

Aim:to show the progress of the experiment of cultivation of human liver cells and adipose-derived mesenchymal stromal cells in perfusion bioreactor.Materials and methods.The cultivation of a cell-engineered construct, consisting of a biopolymer microstructured collagen-containing hydrogel, human liver cells, adipose-derived mesenchymal stromal cells, and William’s E Medium, was performed in a perfusion bioreactor.Results.On the 7th day large cells with hepatocyte morphology – of a polygonal shape and a centrally located round nucleus, – were present in the culture chambers of the bioreactor. The metabolic activity of hepatocytes in cell-engineered constructs was confi rmed by the presence of urea in the culture medium on the seventh day of cultivation in the bioreactor and by the resorption of a biopolymer microstructured collagen-containing hydrogel.
COMPLEX APPROACH FOR PORTABLE CRYOPRESERVATION OF SEGMENTS OF BLOOD VESSELS WITH POLYDIMETHYLSILOXANE
Authors: Lauk-Dubitsky S. E. , Astrelina T. A. , Fedyunin A. A. , Burkov I. A. , Kildyushov E. M. , Lischuk S. V. , Novikov I. A. , Pushkarev A. V. , Brumberg V. A. , Shakurov A. V. , Samchuk D. P. , Kobzeva I. V. , Suchkova Yu. B. , Nikitina V. A. , Karaseva T. V. , Bushmanov A. Yu. , Samoilov A. S. 
Published: April 2018

Aim.To develop a safe protocol for cryopreservation of segments of iliac arteries straight after their retrieval from post-mortem donor with the use of polydimethylsiloxane as a coolant and cryoprotectant.Materials and methods.Eleven segments of iliac arteries were retrieved from post-mortem donor and divided into four groups including control. Based on preliminary heat and cold transfer mathematical modeling and tests with tissueequivalent phantom arterial segments were placed on plastic mounts and cryopreserved by following protocol: groups 1 and 2 were immersed in polydimethylsiloxane and cooled rapidly at 180 °С/min to –75 °С. Group 3 segments were cryopreserved at 1,6 °С/min in PDMS – fi lled cryo-container placed in the freezer at –80 °С. All segments were defrosted by immersion in PDMS at +24 °С and then examined for morphology changes by histological methods and SEM. EDS analysis with the use of AzTech software also was performed for Si – content evaluation. Restricted biomechanical tests were conducted for group 2 segments.Results.There were no signifi cant morphological differences between segments of the control and cryopreserved groups except for the segment with slow cooling.Conclusion.Mobile cryopreservation may allow increasing the effi ciency of retrieval of a large number of donor tissues for possible later use in the processing of bioprostheses of blood vessels; or, after decellularization, as well as tissue-specifi c matrices for tissue-engineering blood vessels.
INFLUENCE OF bFGF, SDF-1α, OR VEGF INCORPORATED INTO TUBULAR POLYMER SCAFFOLDS ON THE FORMATION OF SMALL-DIAMETER TISSUE-ENGINEERED BLOOD VESSEL IN VIVO
Authors: Antonova L. V. , Sevostyanova V. V. , Kutikhin A. G. , Velikanova Е. A. , Matveeva V. G. , Glushkova T. V. , Mironov A. V. , Krivkina E. O. , Barbarash O. L. , Barbarash L. S. 
Published: April 2018

Aim. To evaluate the potential synergistic effects of basic fi broblast growth factor (bFGF) and stromal cell-derived factor-1α (SDF-1α) complemented with VEGF compared to VEGF alone when being added into poly(3-hydroxybutyrateco-3-hydroxyvalerate) / poly(ε-caprolactone) vascular grafts implanted into rat abdominal aorta for 3, 6, or 12 months.Materials and methods. Utilizing emulsion electrospinning, we fabricated one-layer vascular grafts with either VEGF, bFGF, or SDF-1α, and two-layer vascular grafts with VEGF incorporated into the inner layer and bFGF and SDF-1α incorporated into the outer layer following structural evaluation, tensile testing, andin vivotesting using a rat abdominal aorta replacement model.Results. Grafts containing all three growth factors had a 100% primary patency rate. The combination of bFGF, SDF-1α and VEGF improved morphology and mechanical properties of the grafts. Furthermore, such combination of the bioactive factors promoted endothelialization compared to VEGF alone. In addition, bFGF induced a rapid formation of a SMC layer.Conclusion. Taking together, these fi ndings show that the incorporation of bFGF and SDF-1α into the vascular grafts in combination with VEGF enhances vascular tissue regeneration and provides a higher primary patency rate.
A Critical View on the Intensified Adjectives in Turkish
Authors: KOÇ Ebru 
Published: April 2018

The aim of this research is to investigate the
tendency of native speakers of Turkish when intensifying adjectives in Turkish
and examine whether there is a rule that governs which of the consonants (m, p, r, or s) are used in intensifying adjectives. The participants of the study were 190 native
speakers of Turkish whose ages ranged from 18 to 56. A list containing 21 adjectives was used to
collect data. The data were analyzed in terms of the frequencies of usage. The results showed that in intensifying the
21 adjectives in the list, ‘p’ was the most frequently used consonant, and ‘r’
was the least frequently used consonant.
Another significant finding of the study was that most of the adjectives
seemed to have more than one intensified form.
Kronik Böbrek Yetmezliği Olan Çocukların Ebeveynlerinin Depresyon Düzeyleri ve Stresle Başa Çıkma Tarzları
Authors: EVGİN Derya , ERDEM Emine 
Published: April 2018

Amaç: Çalışma, çocuğu KBY
tanısıyla izlenen ebeveynlerin depresyon düzeyleri ve stresle başa çıkma
tarzlarının belirlenmesi amacı ile tanımlayıcı olarak yapılmıştır.Yöntem: 1 Aralık 2008-1 Mart
2009 tarihleri arasında bir üniversite hastanesinin Pediatrik Nefroloji Klinik
ve Polikliniği'nde çocuğu KBY olan 52 ebeveyn örnekleme alınmıştır. Çalışmanın
yapılması için etik kurul izni ve ebeveynlerden yazılı onam alınmıştır. Veri toplama aracı
olarak ebeveynlerin tanıtıcı özellikleri, hastalık ve tedaviye ilişkin
bilgilerini içeren anket formu, Beck Depresyon Envanteri (BDE) ve Stresle Başa
Çıkma Tarzları Ölçeği (SBTÖ) kullanılmıştır. Verilerin değerlendirilmesinde;
tanımlayıcı istatistikler, homojenlik, korelasyon ve iki ortalama arasındaki
farkın önemlilik testleri kullanılmıştır.
Bulgular: Çalışmada,
annelerin depresyon puan ortalamaları 21.53 ± 13.82,
babaların 18.83 ± 13.41 olarak bulunmuştur (p&gt;0.05). Çocuk sayısı, hastalığa ilişkin bilgi ve hastanede
refakatçi kalma durumunun ebeveynlerin depresyon puanları üzerinde etkili
olduğu saptanmıştır (p&lt;0.05). Annelerin SBTÖ’nin
tüm alt gruplarından aldıkları puan ortalamalarının babalardan yüksek olduğu
bulunmuştur (p&gt;0.05). Çalışmada, annelerin çaresiz yaklaşım ve boyun
eğici yaklaşım puanları ile depresyon puanları arasında pozitif bir ilişki
olduğu, babaların ise, çaresiz yaklaşım puanları ile depresyon puanları
arasında pozitif bir ilişki olduğu saptanmıştır.

Sonuç: Bu
sonuçlar doğrultusunda, stresle etkili baş etme yöntemlerine ilişkin
ebeveynlere eğitim verilmesi, ebeveyn destek grubunun oluşturulması
önerilmektedir.
Atipik şikayetlerle prezente olan akut travmatik interhemisferik subdural hematom
Authors: Ak Hakan , Daltaban İskender Samet , Albayrak Levent , Çaltekin İbrahim 
Published: April 2018

Özet

Akut interhemisferik subdural
hematom akut subdural hematomun nadir görülen bir tipi olup genellikle kafa
travmasından sonra ortaya çıkmaktadır. Bu hematomda görülen klinik belirti ve bulgular
arasında baş ağrısı, bulantı kusma, nöbet, demans, görme bozukluğu, monoparezi,
ve hemiparezi bildirilmiştir. Bu yazıda bunalma ve terleme hissi gibi atipik
şikayetlerle başvuran 54 yaşındaki bir erkek hastada saptanan interhemisferik
subdural hematom olgusunu sunulmaktadır. Hasta sadece klinik gözlem ile takip
edilmiş olup 10 gün sonra hematomum tamamıyla rezorbe olduğu görülmüştür. Sonuç
olarak, interhemisferik subdural
hematomda vital bulguların ve nörolojik durumun stabil seyretmesi durumunda
sadece izlem yeterli olabilmektedir.
Hospitalização da criança: sentimentos e opiniões dos pais
Authors: Antão Celeste , Rodrigues Nicole , Sousa Filomena , Anes Eugénia , Pereira Ana 
Published: April 2018

Introdução: A doença e a hospitalização constituem uma situação de crise tanto para a criança como para a família pois implicam alterações financeiras, psicológicas, relacionais e sociais. Objetivos: Conhecer os sentimentos e opiniões de pais face à hospitalização de filhos numa unidade de pediatria e identificar os profissionais que mais os apoiaram nesse período. Metodologia: Trata-se de um estudo descritivo, no qual foi utilizada uma amostra de 33 pais/acompanhantes. Após autorização do Conselho Diretivo do Hospital e o Consentimento informado aos inquiridos foi aplicado um questionário aos pais/acompanhantes de crianças hospitalizadas no serviço de pediatria no Centro Hospitalar Trás-os-Montes e Alto Douro - Vila Real. Resultados: A idade dos participantes está compreendida entre os 21 e os 46 anos de idade, sendo que a maioria tem 30 e 35 anos. 87,9% das crianças estava acompanhada pela mãe e 15,2% das crianças já tinham sido internadas entre 3 (6,1%) a 5 vezes (9,1%). Durante o internamento, os pais vivenciaram sentimentos ambivalentes. Os sentimentos negativos mais expressivos foram a ansiedade, a tristeza e o medo. Evidenciam-se como sentimentos positivos a esperança, a segurança e o interesse. Verificamos que o internamento dos filhos implicou adaptação dos pais a novas rotinas (93,9%), bem como a mudanças na vida social e laboral. Os inquiridos consideram a sua relação com o enfermeiro como boa (48,5%) e 36,3% de muito boa. Salientamos que 9,1% apenas a considerou de suficiente. Conclusão: É fundamental numa situação de hospitalização compreender os sentimentos da família, onde os profissionais de saúde, nomeadamente os enfermeiros, devem contribuir para o desenvolvimento de estratégias que permitam à família e doente uma melhor adaptação à situação vivida.
Taxonomic note on the type species of <i>Centris</i> (<i>Melanocentris</i>) (Hymenoptera: Apidae)
Authors: Vivallo Felipe 
Published: April 2018

Centris (Melanocentris) Friese is one of many subgenera that have been proposed throughout the taxonomic history of the bee genus Centris Fabricius. The lack of critical study of the type specimens of its type species, Centris atra Friese, resulted in the synonymy of Melanocentris with subgenus Ptilotopus Klug. Subsequently, Melacentris Moure was described as a new subgenus to group the large number of species identified as Melanocentris before the synonymy was proposed. The study of the syntypes of C. atra and the designation of a lectotype (herein) leads to the revalidation of Melanocentris as a subgenus distinct from Ptilotopus, and necessitates the new synonymy of Melacentris with Melanocentris.
Client-Server Based Authentication Against MITM Attack via Fast Communication for IIoT Devices
Authors: KARA Mustafa , FURAT Murat 
Published: April 2018

Security is an important issue that should
be taken care of by every system. In recent years, however, attackers are
constantly developing themselves with new techniques to obtain personal
information on the network. As systems evolve, the data that needs to be
protected is increasingly appreciated and carries a higher risk of attack. As
with many attacks such as MITM, there are solutions against this attacks.
Nevertheless, these safety measures must be developed continuously. For this
reason, we have developed a new system architecture with user-defined
authentication against the intruders for the systems having large amount of data
transmission rate. To maintain integrity of data, over a reliable system is
that all incoming data are authenticated when data send to the server, on the
other hand, in this system, the user-defined authentication can provide fast
communication and it can decrease authentication time. The proposed system
introduced in the present study checks for any changes in our instantaneous
data. Moreover, we control the data integrity on simple devices such as sensors
and motors or other industrial devices. Instead of using encryption, basically
client-server based authentication system is used to avoid complex operations
and protect the big data.
A molecular genetic research of the Triticum sinskajae A. Filat. et Kurk. by RAPD analysis and by comparing the nucleotide sequences of the variable intergenic region of the petN-trnC-GCA chloroplast genome and intron of the histone H3.2 gene
Authors: Kuluev Azat R. , Matnijazov Rustam T. , Kuluev Bulat R. , Chemeris Alexey V. 
Published: April 2018

Background. Triticum sinskajae A. Filat. et Kurk. was discovered in the early 70th in the last century at the regular reproduction in the Central Asian and Dagestan VIR-stations of T. monococcum samples.
Materials and methods. The objects of the study were 4 species of diploid wheat Triticum urartu Thum. ex Gandil. (lines k-62477, k-62465), Triticum monococcum L. (lines k-20970, k-39471), Triticum boeoticum Boiss. (lines k-59161, k-28132, k-40118) and Triticum sinskajae A. Filat. et Kurk. (line k-48993).
Results. We found differences between T. sinskajaeand T. monococcum in the variable region of the histone gene H3.2, and the RAPD analysis showed the presence of unique polymorphic loci in T. sinskajae.
Conclusion. In gene ral, T. boeoticum, T. monococcum, and T. sinskajae are most likely to be closely related species of diploid wheat, whereas T. urartu is quite significantly different from them.
Association between cytokine gene polymorphisms and squamous cell lung cancer depending on the duration of smoking in men
Authors: Gordeeva Lyudmila A. , Mun Stella A. , Voronina Elena N. , Polenok Elena G. , Magatina Alina D. , Titov Viktor A. , Ragozhina Svetlana E. , Vafin Ilgiz A. , Romanova Elizaveta L. , Glushkov Andrey N. 
Published: April 2018

Background. Squamous cell lung cancer (SCLC) is the most common form of lung cancer among men smokers. Mediators and products of inflammation can contribute to the initiation of carcinogenesis in smokers. The aim of study is to investigate the association between IL1B(rs1143634, rs16944), IL1RN (rs2234663), TNFA (rs1800629), IL6 (rs1800795), IL10 (rs1800896) genes and SCLC depending on the duration of smoking in men.
Materials and methods. We studied 324 patients with SCLC and 168 healthy men smokers. The typing of the IL1RN(rs2234663) gene polymorphism has analyzed by polymerase chain reaction (PCR). Detection of the IL1B (rs1143634) and IL6 (rs1800795) polymorphisms have performed by restriction fragment length analysis, as a restriction enzyme TaqI was used. The IL1B (rs16944), TNFA(rs1800629) and IL10 (rs1800896) genes polymorphisms have determined through TaqMan-real-time PCR.
Results. The study showed, the age, duration of smoking and the number of cigarettes smoked per day were the main risk factors for SCLC in men (p 0.0001). The IL6 -174G allele was detected an additional risk factor of SCLC at a smoking duration of less than 35 years (OR = 1.68; 95 % CI: 1.12-2.51; pcor = 0,04). No association of IL1B (rs1143634, rs16944), IL1RN (rs2234663), TNFA (rs1800629), and IL10 (rs1800896) genes with the risk of SCLC in men was identified.
Conclusion. The duration of smoking and rs1800795 IL6 gene polymorphism may influence on the susceptibility to SCLC in men. Our results can be useful in understanding the molecular mechanisms of development of SCLC.
Lefkoşa’nın bir bölgesinde altmış beş yaş ve üzeri bireylerin sosyal yaşama katılımı
Authors: AŞUT Özen , VAİZOĞLU Songül , BOZYEL Funda , SUCUOĞLU Asya , PEKTEKİN Ceren , ASİF Günay , KARAHANCI Esat Cihan , İNCEBIYIK Mehmet , CALİ Sanda 
Published: April 2018

Amaç: Bu araştırmanın amacı, Lefkoşa’nın bir bölgesindeki 65 yaş ve üzeri bireylerin sosyal yaşama katılım düzeyini belirlemek olarak tanımlanmıştır. Gereç ve Yöntem: Tanımlayıcı nitelikte olan araştırmanın evrenini, Lefkoşa ilçesi Göçmenköy bölgesinde yaşayan ve 2011 nüfus sayımına göre belirlenen 65 yaş ve üstü 515 birey oluşturmaktadır. Nüfusun tümüne ulaşılması hedeflenmiş, araştırmacılar evlerde yüz yüze anket uygulayarak veri toplamışlardır. Bulgular: Katılımcıların %57’si kadın, yaş ortalaması 73.0±6.6 yıl, %68’i evlidir. Katılımcıların %78’inde en az bir hastalık bulunmaktadır. Katılımcıların yalnızca %2.4’ü gelir getirici bir işte çalışmakta; %16’sı günlük etkinliklerde yardıma gereksinim duymaktadır. Teknoloji kullanımı cep telefonu dışında %50’nin altındadır. Araba ve cep telefonu kullanımı erkeklerde önemli derecede daha yüksektir. Evli olanlarda ve eğitim düzeyi ortaokul ve üstünde olanlarda teknoloji kullanımı, alışveriş yapma, dışarı yalnız çıkma ve yürüyüş yapma düzeyleri istatistiksel olarak önemli derecede daha yüksektir.Sonuç: Bu çalışmada, yaşlı nüfusun, özellikle kadınların sosyal katılımı yetersiz bulunmuştur. Yaşlılığa bağlı kısıtlılıklar, sosyal ve fiziksel diğer belirleyiciler, yaşlıların sosyal katılımını engelleyebilmektedir. Oysa sosyal katılım yaşlıların yaşam kalitesini artırmakta, ayrıca topluma sosyoekonomik katkı sağlamaktadır. Bu nedenle, kamunun görevi engelleri ortadan kaldırmak olmalıdır.