bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes More Than 2 Years After Meniscal Repair for Radial/Flap Tears of the Posterior Lateral Meniscus Combined With Anterior Cruciate Ligament Reconstruction
Authors: Tsujii Akira , Yonetani Yasukazu , Kinugasa Kazutaka , Matsuo Tomohiko , Yoneda Kenji , Ohori Tomoki , Hamada Masayuki 
Published: August 2019

Background: Meniscal function after repair of radial/flap tears of the posterior horn of the lateral meniscus (LM) with anterior cruciate ligament reconstruction (ACLR) has not been comprehensively investigated. Purpose: To evaluate not only the clinical and radiographic outcomes of patients with repair of radial/flap tears of the posterior LM with ACLR but also the healing status of the repaired meniscus and changes of chondral status with second-look arthroscopy. Study Design: Case series; Level of evidence, 4. Methods: From January 2008 to April 2016, 41 patients of a consecutive series of 505 primary anatomic ACLR cases had a concomitant radial/flap tear of the posterior horn of the LM and underwent side-to-side repair with an inside-out or all-inside technique. All patients were followed for >2 years, evaluated clinically and radiologically (radiograph and magnetic resonance imaging [MRI]), and compared with a control group without any concomitant injuries that underwent ACLR. Of the 41 patients, 30 were assessed by second-look arthroscopy 2 years postoperatively. Results: The mean follow-up times of the study and control groups were 3.4 and 3.9 years, respectively. The study group showed no significant differences in clinical findings, lateral joint space narrowing on radiograph, and coronal extrusion on MRI as compared with the control group, whereas sagittal extrusion on MRI progressed significantly in the study group (1.2 ± 1.5 mm vs 0.32 ± 1.0 mm, P < .001). Eighteen patients (60%) obtained complete healing; 9 (30%) showed partial healing; and 3 (10%) failed to heal on second-look arthroscopy. Changes of chondral status in the femoral condyle showed no significant difference between the groups ( P = .29). However, chondral status of the lateral tibial plateau worsened significantly in the study group ( P = .0011). Conclusion: The clinical and radiographic outcomes after repair of radial/flap tears of the posterior horn of the LM as combined with anatomic ACLR were successful and comparable with those after isolated ACLR without any other injuries at a mean postoperative follow-up of 3.4 years, except for sagittal extrusion on MRI. Chondral lesions of the lateral tibial plateau deteriorated regardless of meniscal healing at 2 years postoperatively. Surgeons should keep in mind that chondral injuries might progress over the midterm.
Related and unrelated donor transplantation for β-thalassemia major: results of an international survey
Authors: Li Chunfu , Mathews Vikram , Kim Soyoung , George Biju , Hebert Kyle , Jiang Hua , Li Changgang , Zhu Yiping , Keesler Daniel A. , Boelens Jaap Jan , Dvorak Christopher C. , Agarwal Rajni , Auletta Jeffery J. , Goyal Rakesh K. , Hanna Rabi , Kasow Kimberly , Shenoy Shalini , Smith Angela R. , Walters Mark C. , Eapen Mary 
Published: August 2019

Abstract
We studied 1110 patients with β-thalassemia major aged ≤25 years who received transplants with grafts from HLA-matched related (n = 677; 61%), HLA-mismatched related (n = 78; 7%), HLA-matched unrelated (n = 252; 23%), and HLA-mismatched unrelated (n = 103; 9%) donors between 2000 and 2016. Ninety percent of transplants were performed in the last decade. Eight-five percent of patients received ≥20 transfusions and 88% were inadequately chelated. All patients received myeloablative-conditioning regimen. Overall and event-free survival were highest for patients aged ≤6 years and after HLA-matched related and HLA-matched unrelated donor transplantation. The 5-year probabilities of overall survival for patients aged ≤6 years, 7 to 15 years, and 16 to 25 years, adjusted for donor type and conditioning regimen were 90%, 84%, and 63%, respectively (P &lt; .001). The corresponding probabilities for event-free survival were 86%, 80%, and 63% (P &lt; .001). Overall and event-free survival did not differ between HLA-matched related and HLA-matched unrelated donor transplantation (89% vs 87% and 86% vs 82%, respectively). Corresponding probabilities after mismatched related and mismatched unrelated donor transplantation were 73% vs 83% and 70% vs 78%. In conclusion, if transplantation is considered as a treatment option it should be offered early (age ≤6 years). An HLA-matched unrelated donor is a suitable alternative if an HLA-matched relative is not available.
"If you catch my drift...": ability to infer implied meaning is distinct from vocabulary and grammar skills
Authors: Wilson Alexander C. , Bishop Dorothy V.M. 
Published: August 2019

Background: Some individuals with autism find it challenging to use and understand language in conversation, despite having good abilities in core aspects of language such as grammar and vocabulary. This suggests that pragmatic skills (such as understanding implied meanings in conversation) are separable from core language skills. However, it has been surprisingly difficult to demonstrate this dissociation in the general population. We propose that this may be because prior studies have used tasks in which different aspects of language are confounded. Methods: The present study used novel language tasks and factor analysis to test whether pragmatic understanding of implied meaning, as part of a broader domain involving social understanding, is separable from core language skills. 120 adult participants were recruited online to complete a 7-task battery, including a test assessing comprehension of conversational implicature. Results: In confirmatory analysis of a preregistered model, we compared whether the data showed better fit to a two-factor structure (including a “social understanding” and “core language” factor) or a simpler one-factor structure (comprising a general factor). The two-factor model showed significantly better fit. Conclusions: This study supports the view that interpreting context-dependent conversational meaning is partially distinct from core language skills. This has implications for understanding the pragmatic language impairments reported in autism.
The Real Effects of Bank Capital Requirements
Authors: Fraisse Henri , Lé Mathias , Thesmar David 
Published: August 2019

We measure the impact of bank capital requirements on corporate borrowing, investment, and employment using loan-level data. The Basel II regulatory framework makes capital requirements vary across both banks and firms, which allows us to control for time-varying firm-level risk and bank-level credit supply shocks. We find that a 1 percentage point increase in capital requirements reduces lending by 2.3%–4.5%. Firms can attenuate this reduction by substituting borrowing across banks, but only to a limited extent. The resulting reduction in borrowing capacity affects significantly both investment and employment: for firms whose effective capital requirements increase by 1 percentage point, fixed assets are reduced by 1.1%, capital expenditures by 2.7%, and employment by 0.8%. This paper was accepted by Tomasz Piskorski, finance.
Difficult Preoperative Diagnosis of Lymphoepithelioma-Like Carcinoma of the Esophagus
Authors: Okata Tomoki , Uno Kaname , Fujishima Fumiyoshi , Saito Masahiro , Jin Xiaoyi , Hatta Waku , Asanuma Kiyotaka , Asano Naoki , Koike Tomoyuki , Imatani Akira , Masamune Atsushi 
Published: August 2019

ABSTRACT
A 60-year-old man with a medical history of diabetes, liver cirrhosis, and distal gastrectomy was referred for further examination of a 10-mm pale-colored submucosal tumor around 40 cm from the incisors. Narrow band imaging–magnifying endoscopy revealed the lesion covered by smooth epithelium with irregular microvascular architecture in a sparse distribution. Endosonography showed an irregular-shaped hypoechoic lesion in the submucosa. With no evidence of metastases, we performed en bloc endoscopic submucosal dissection, whose specimen revealed esophageal lymphoepithelioma-like carcinoma invading up to 500 μm in the submucosa, a rare disease entity. Despite no additional treatment, he was alive without recurrence for longer than 88 months.
Acute Colonic Pseudo-Obstruction as a Manifestation of Lead Intoxication in a Conservator
Authors: Costa-Moreira Pedro , Coelho Rosa , Pita Inês , Macedo Guilherme 
Published: August 2019

ABSTRACT
We report a case of a 39-year-old art conservator who presented complaining of abdominal pain and constipation. His laboratory results showed normocytic normochromic anemia and abnormal liver tests. Computed tomography revealed distention of the whole colon without obstruction. Evaluation of anemia was compatible with nonimmune hemolysis. A liver biopsy showed accumulation of ferric pigment in Kupffer cells. Given the typical findings in the blood smear and the epidemiological context, a serum lead assay was performed (92 μg/dL). This clinical case illustrates the need for gastroenterologists to recognize digestive manifestations of systemic diseases, including intoxications.
Endoscopic Management of Giant Walled-Off Pancreatic Necrosis With a High Risk of Bleeding
Authors: Alhasan Faysal , Hoilat Gilles Jadd , Malas Waddah , Mahmood Syed K. , Zivny Jaroslav , Alsayid Muhammad 
Published: August 2019

ABSTRACT
Walled-off pancreatic necrosis (WOPN) is one of the late complications of acute pancreatitis. We present a 37-year-old man who developed a large WOPN 6 weeks after treatment of severe complicated pancreatitis. Imaging studies revealed a necrotic retroperitoneal fluid collection measuring 27 × 12 × 27 cm with large crossing blood vessels. Cystogastrostomy was performed using a lumen-apposing metal stent. He underwent multiple necrosectomies with significant improvement in the cyst size. Bleeding is a major complication of direct endoscopic necrosectomy; hence, specific imaging and a careful approach should be taken into consideration, especially in WOPN with a high risk of bleeding.
Hypokalemia-Induced Rhabdomyolysis From Budesonide Therapy in Crohn's Disease
Authors: Mansour Ramy , Mandiga Pujyitha , Thigpin Derek 
Published: August 2019

ABSTRACT
We present a 71-year-old white man with active ileocolonic Crohn's disease, recently started on budesonide therapy, who presented with extreme weakness and muscle aches. He was diagnosed with hypokalemia-induced rhabdomyolysis, 3 weeks after starting budesonide therapy. His symptoms and laboratory values improved with budesonide discontinuation and appropriate fluid and electrolyte replacement. This is only the second case of hypokalemia-induced rhabdomyolysis secondary to budesonide.
Manuais pedagógicas na formação de professores no espaço luso-brasileiro (1870-1970)
Authors: Leal Soares Edilene Alexandra 
Published: August 2019

SILVA, Vivian Batista. Saberes em viagem nos manuais pedagógicos. Construções da Escola em Portugal e no Brasil (1870 – 1970). São Paulo: Editora UNESP. 2018. 506p.
A obra “Saberes em viagem nos manuais pedagógicos. Construções da Escola em Portugal e no Brasil (1870 – 1970)” é leitura essencial aos pesquisadores e interessados em engendrar pelo estudo dos manuais pedagógicos.Este livro é fruto de uma pesquisa de grande densidade, com realização de investigação meticulosa e análise criteriosa de manuais pedagógicos em circulação no Brasil e em Portugal que eram utilizados na formação de normalistas no período de 1870 a 1970 e, traz à tona as ideias difundidas no processo de formação deste importante ofício da Modernidade.
Next-generation sequencing for tumor mutation quantification using liquid biopsies
Authors: Provencio Mariano , Pérez-Barrios Clara , Barquin Miguel , Calvo Virginia , Franco Fabio , Sánchez Estela , Sánchez Ricardo , Marsden Daniel , Cristóbal Sánchez Juan , Martin Acosta Paloma , Laza-Briviesca Raquel , Cruz-Bermúdez Alberto , Romero Atocha 
Published: August 2019

Abstract

Background
Non-small cell lung cancer (NSCLC) patients benefit from targeted therapies both in first- and second-line treatment. Nevertheless, molecular profiling of lung cancer tumors after first disease progression is seldom performed. The analysis of circulating tumor DNA (ctDNA) enables not only non-invasive biomarker testing but also monitoring tumor response to treatment. Digital PCR (dPCR), although a robust approach, only enables the analysis of a limited number of mutations. Next-generation sequencing (NGS), on the other hand, enables the analysis of significantly greater numbers of mutations.

Methods
A total of 54 circulating free DNA (cfDNA) samples from 52 NSCLC patients and two healthy donors were analyzed by NGS using the Oncomine™ Lung cfDNA Assay kit and dPCR.

Results
Lin’s concordance correlation coefficient and Pearson’s correlation coefficient between mutant allele frequencies (MAFs) assessed by NGS and dPCR revealed a positive and linear relationship between the two data sets (ρc = 0.986; 95% confidence interval [CI] = 0.975–0.991; r = 0.987; p < 0.0001, respectively), indicating an excellent concordance between both measurements. Similarly, the agreement between NGS and dPCR for the detection of the resistance mutation p.T790M was almost perfect (K = 0.81; 95% CI = 0.62–0.99), with an excellent correlation in terms of MAFs (ρc = 0.991; 95% CI = 0.981–0.992 and Pearson’s r = 0.998; p < 0.0001). Importantly, cfDNA sequencing was successful using as low as 10 ng cfDNA input.

Conclusions
MAFs assessed by NGS were highly correlated with MAFs assessed by dPCR, demonstrating that NGS is a robust technique for ctDNA quantification using clinical samples, thereby allowing for dynamic genomic surveillance in the era of precision medicine.
Ovarian torsion of a term pregnancy – a new twist: review of the literature and management
Authors: McNally Stephanie Trentacoste 
Published: August 2019

Abstract

Background
Ovarian and adnexal torsions are gynecologic emergencies [Li Q, Li X, Zhang P. Ovarian torsion caused by hyperreactio luteinalis in the third trimester of pregnancy: a case report. Int J Clin Exp Med. 2015;8:19612–5; Ssi-Yan-Kai G, Rivain AL, Trichot C, Morcelet MC, Prevot S, Deffieux X. What every radiologist should know about adnexal torsion. Emerg Radiol. 2018;25:51–9; Huchon C, Fauconnier A. Adnexal torsion: a literature review. Eur J Obstet Gynecol Reprod Biol. 2010;150:8–12].

Case presentation
Though rare in pregnancy, this case report describes a 32-year-old G0 at 39 + 3/7 weeks with a history of kidney stones and a simple ovarian cyst that presented to the labor floor with left lower quadrant pain. She underwent an induction of labor for persistent pain and had a subsequent primary section for a category II tracing.

Conclusion
During the section, a torsion x3 of the left infundibular ligament was noted. The pathology indicated an acute infarct – only one other case of a full-term torsion was found in the literature (Li Q, Li X, Zhang P. Ovarian torsion caused by hyperreactio luteinalis in the third trimester of pregnancy: a case report. Int J Clin Exp Med. 2015;8:19612–5).
Multilayer SIW Dual-Band Filters with Independent Band Characteristics and High Selectivity
Authors: Jia Dinghong , Deng Jianqin , Zhao Yangping , Wu Ke 
Published: August 2019

Abstract
This work presents an approach to developing dual-mode dual-band substrate integrated waveguide (SIW) bandpass filter based on multilayer process. TE102/TE201 and TE101/TE102 modes are used to feature the two passbands, respectively. To begin with, large range of band location ratios are decided by the effective dimension of the SIW resonator. With reference to the field distribution, independent coupling schemes of the dual-modes are then realized by slots or circular apertures etched on the middle metal layer. It allows to not only introduce a large design freedom of bandwidth but also keep compactness. Finally, source-load and mixed couplings are deployed to produce transmission zeros around the passband in providing a sharp selectivity in the two filters, respectively. The details to independently control the center frequencies and bandwidth of two passbands are also presented. A two-order double-layered and a triple-layered SIW dual-band bandpass filter are prototyped to evaluate the proposed design approach, respectively. Results show a good agreement between simulations and measurements. The proposed filter exhibits flexible design freedom, high selectivity as well as good out-of-band rejection.
Natural Disasters vs Hotel Industry Resilience: An Exploratory Study among Hotel Managers from Europe
Authors: Ivkov Milan , Blešić Ivana , Janićević Sava , Kovačić Sanja , Miljković Ðurđa , Lukić Tin , Sakulski Dušan 
Published: August 2019

Abstract
Hotels, like any other businesses in a given location, can be threatened by natural disasters, usually with significant and long-term consequences. The hotel industry is particularly vulnerable and exposed to the risk of property being physically damaged or completely destroyed. Apart from the physical damage, there is also an accompanying economic risk of the tourism sector suffering as tourists avoid areas affected by a disaster event. Therefore, hotels in the areas prone to natural disasters must ensure they are resilient enough to carry on through the turbulent period until regular business levels return. This study is based on survey responses of 63 hotel managers from the 12 European countries most frequently affected by natural disasters. The study relies on multi-capital predictor based approach and examines hotel resilience to natural disasters. It has been found that managers’ previous experience of a natural disaster, duration of managerial experience, and organizational category and size have a positive effect on hotel resilience. Moreover, hotels must anticipate such situations and continuously drill how to respond efficiently and adapt quickly in order to ensure business sustainability. Practical implications, study limitations and future research recommendations are also discussed.
Evaluation of biomarkers of stress in chronic stress-exposed comorbid depression model Wistar rats
Authors: Gokul Megha , Arun Kumar Nayanatara , Durgadas Kini Rekha , Blossom Vandana , Kodavanji Bhagyalakshmi , Noojibail Anupama , Murali Nirupama , Vishwanath Rai Santosh Phajir 
Published: August 2019

Abstract

Background
In recent years, increased stress in human life has a dual effect on brain and body physiology. Chronic stress takes a toll on physiology as well as on quality of life, ultimately leading to affective disorders. Rodent models are indispensable tools for studying the etiology and progress of depression. C-reactive protein has been proposed as a novel inflammatory marker.

Methods
Rats were divided into control and experimental stress groups (n = 6 each). The experimental group consisted of rats that were exposed to a set of chronic unpredictable stressors for 15 days. At the end of the 15th day, the animals were anesthetized, and blood samples were collected through cardiac puncture. Then the blood samples were analyzed for selected biochemical and oxidative stress parameters.

Results
Serum glutamic oxaloacetic transaminase (p < 0.0001), serum glutamic pyruvic transaminase (p < 0.001), serum malondialdehyde (p < 0.0001), total antioxidant level (p < 0.0001), and serum cortisol (p < 0.0001) were significantly increased in the stressed group when compared with the control group. C-reactive protein significantly (p < 0.0001) increased in the stressed group when compared with the control group.

Conclusion
Our results demonstrate that chronic unpredictable stress ameliorated depression-like behavior, which might have caused the dysregulation of the hypothalamic-pituitary-adrenal axis, causing the imbalance in the biochemical and oxidative parameters increasing the inflammatory markers. The inflammation-induced model of the chronic unpredictable stress model of comorbid depression might provide a variety of new targets for antidepressant therapies.
Clopidogrel-induced hemarthrosis following knee replacement
Authors: Chundankuzhiyil Mathew Abel , Poothankandi Athira , Khader Rahana , Chandrasekhar Dilip 
Published: August 2019

Abstract

Background
Clopidogrel is an adenosine diphosphate receptor antagonist used in patients with atherosclerotic vascular disease to reduce the incidence of ischemic events.

Case Presentation
A 62-year-old woman developed a spontaneous hemarthrosis of her left knee following clopidogrel treatment. To date, no case of spontaneous hemarthrosis following clopidogrel monotherapy was reported. Prompt aspiration after discontinuing clopidogrel by conservative management can assist early diagnosis and prevent further damage to the joint. The assessment of the causality of the event was carried out via Naranjo Causality Assessment Scale. A score of 5 was reported for this patient, indicating clopidogrel as a probable cause of this reaction.

Conclusion
We conclude that spontaneous hemarthrosis is a possible complication following clopidogrel therapy and it needs assessment when appropriate clinical symptoms (e.g. intra-articular effusion, pain) are present.
Instrumental Variables Estimation in Large Heterogeneous Panels with Multifactor Structure
Authors: Forchini Giovanni , Jiang Bin , Peng Bin 
Published: August 2019

Abstract
The paper proposes new instrumental variables estimators for the slope parameters of a panel data model with classical endogeneity in which all the observables – including the instruments – may have a common factors structure. These estimators are shown to be consistent and asymptotically normal under weak regularity conditions. A small Monte Carlo simulation shows that these estimators compare favourably to existing estimators.
The effectiveness of enzyme replacement therapy on cardiac findings in patients with mucopolysaccharidosis
Authors: Bilginer Gurbuz Berrak , Aypar Ebru , Coskun Turgay , Alehan Dursun , Dursun Ali , Tokatli Aysegül , Sivri Hatice Serap 
Published: August 2019

Abstract

Background
This study aimed to determine cardiac findings in patients with mucopolysaccharidosis (MPS) and to assess the changes in these findings after enzyme replacement therapy (ERT).

Methods
A retrospective clinical cohort study was conducted on patients who were diagnosed with MPS between 1995 and 2018 in Hacettepe University, Division of Pediatric Metabolism. A total of 96 patients were diagnosed with MPS during the study period. Of these patients, 81 (84.3%) received ERT. Echocardiographic findings of the patients together with the 6-min walking test (6MWT) results before and after ERT were compared.

Results
Thirty-one participants (38.2%) were female, while 50 (61.8%) were male. The mean age of the participants was 11.97 ± 6.33 years (range: 1.8–30). Five patients (6.2%) had MPS type I, 14 (17.3%) had type II, 28 (34.6%) had type IVa, 33 (40.7%) had type VI and one (1.2%) had type VII. Before ERT, 69.4% of patients had mitral insufficiency (MI; mild: 40.5%, moderate: 16.5%, severe: 12.7%), 35.4% had aortic insufficiency (AI; mild: 22.8%, moderate: 12.7%) and 45.1% had tricuspid insufficiency (TI; mild: 39.2%, moderate: 2.5%). The median duration of the ERT was 3.5 years. The ERT significantly improved left ventricular hypertrophy (LVH), but all other study variables returned non-significant before and after treatment. ERT may improve LVH in MPS. Bearing in mind that MPS is a progressive disease, ERT seems to prevent significant deterioration of this ailment but is not able to reverse the already settled pathologies except for LVH. ERT is not able to reverse the damage, but provides stabilization; so it is best to initiate treatment before cardiac damage.