bluuebunny/crossref_metadata_2025_split huggingface dataset:
The New Stand-Alone Surface Analysis at ECMWF: Implications for Land–Atmosphere DA Coupling
Authors: Fairbairn David , de Rosnay Patricia , Browne Philip A. 
Published: August 2019

Abstract
This article presents the “screen-level and surface analysis only” (SSA) system at the European Centre for Medium-Range Weather Forecasts (ECMWF). SSA is a simplification of the operational land–atmosphere weakly coupled data assimilation (WCDA). The goal of SSA is to provide 1) efficient research into land surface developments in NWP and 2) land reanalyses with land–atmosphere coupling. SSA maintains a coupled forecast model between assimilation cycles, but the atmospheric analysis is not performed; rather, it is forced from an archived analysis. Hence, SSA is much faster than WCDA, although it lacks feedback between the land and atmospheric analyses. A global sensitivity analysis was performed over one year to compare the WCDA and SSA systems. Prescribed proxy 2-m temperature/humidity screen-level observation errors were approximately doubled in the soil moisture data assimilation, thereby reducing the average size of the root-zone soil moisture analysis increments by about 60%. The systematic impact of these changes on the WCDA surface and near-surface atmospheric dynamics was effectively captured by SSA, although the short-term impact was underestimated. Importantly, the SSA forecast verification scores accurately reflected those of WCDA: atmospheric 1–10-day temperature/humidity forecasts were degraded in the tropics and lower midlatitudes up to about 700 hPa. The soil moisture analysis performance was not significantly impacted. These results endorse SSA as an NWP research tool and confirm the role of assimilating proxy screen-level observations in the soil moisture analysis to improve weather forecasts. Appropriate use and limitations of SSA are considered.
Semiannual Variability of Middepth Zonal Currents along 5°N in the Eastern Indian Ocean: Characteristics and Causes
Authors: Huang Ke , Wang Dongxiao , Han Weiqing , Feng Ming , Chen Gengxin , Wang Weiqiang , Chen Ju , Li Jian 
Published: August 2019

AbstractFour-year (2014–17) zonal current data observed by a mooring at (5°N, 90.5°E) in the eastern Indian Ocean show a strong semiannual cycle in the middepth (~1200 m) with distinct vertical structure. This pronounced middepth semiannual variability, however, is inconsistent with the local wind forcing, which shows a predominant annual cycle. The underlying causes for this unique middepth variability along 5°N were elucidated with the addition of a reanalysis product and a continuously stratified linear ocean model. The results suggest that the observed seasonal variability in the middepth zonal flow at 5°N is primarily caused by boundary-reflected Rossby waves forced by the remote semiannual winds along the equator. Contribution from the locally wind-forced Rossby waves is much less. The theoretical Wentzel–Kramers–Brillouin ray paths further verify that the strong semiannual variability of the middepth signals over a moored region in the eastern Indian Ocean is largely a manifestation of the steep angles of propagating energy of the long Rossby waves at semiannual time scale. The annual signals are only significant in the upper and western sections (75°–80°E) as a result of the smooth trajectories of Rossby waves forced by local annual winds. Further analysis reveals that the middepth zonal currents along 5°N are expected to be associated with equatorial symmetric Rossby waves at semiannual period. Consequently, similar zonal flows should also exist in the middepth near 5°S.
Vaping Expectancies: A Qualitative Study among Young Adult Nonusers, Smokers, Vapers, and Dual Users
Authors: Harrell Paul T , Brandon Thomas H , England Kelli J , Barnett Tracey E , Brockenberry Laurel O , Simmons Vani N , Quinn Gwendolyn P 
Published: August 2019

Background: “Expectancies,” or beliefs about outcomes, robustly correlate with and predict several behaviors including electronic nicotine delivery system (“e-cigarette”) use. However, there is limited qualitative research available regarding relevant e-cigarette vaping expectancies. Objectives: The present study used a qualitative approach to derive and refine e-cigarette expectancy themes among young adults. Methods: We conducted 12 focus groups and two individual interviews with young adult nonusers, e-cigarette vapers, cigarette smokers, and dual users to assess beliefs about the effects of e-cigarettes. After a series of open-ended questions, follow-up questions assessed reactions to domains previously examined in expectancy measures for cigarette smoking and e-cigarette vaping. The constant comparative method was used to derive themes from transcripts. Results: Four main themes ( Positive Reinforcement, Social Benefits, Negative Affect Reduction, Negative Consequences) emerged from the results. Each theme contained three associated subthemes ( Positive Reinforcement: Sensorimotor Experiences, Taste, Stimulation; Social Benefits: Social Facilitation, Influence on Others, Convenience; Negative Affect Reduction: Stress Reduction, Appetite Reduction, Boredom Reduction; and Negative Consequences: Health Risks, Addiction, Secondhand Effects). Conclusions/importance: Previously identified smoking expectancies appear relevant for young adult vaping, with some notable refinements. Positive reinforcement aspects encompassed aerosol clouds, vaping tricks, and unique flavors. Social benefits included influencing others via social media and competitive activity, as well as the convenience of use in a variety of places. Negative affect reduction was controversial among user groups, but vaping was seen as more interesting than smoking and thus more effective at boredom reduction. Young adults were uncertain regarding negative consequences, but appreciated a potential for secondhand effects. Measure refinement via qualitative research and future field testing can enhance our understanding of this relatively new behavior, supporting tobacco control surveillance, marketing/labeling regulations, and counter-advertising development/evaluation.
Efficacy and safety of dihydroartemisinin–piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non-randomized interventional trial
Authors: Sevene Esperança , Banda Clifford G. , Mukaka Mavuto , Maculuve Sonia , Macuacua Salésio , Vala Anifa , Piqueras Mireia , Kalilani-Phiri Linda , Mallewa Jane , Terlouw Dianne J. , Khoo Saye H. , Lalloo David G. , Mwapasa Victor 
Published: August 2019

Abstract
Background
HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Dihydroartemisinin–piperaquine (DPQ) is recommended for treatment of Plasmodium falciparum malaria, but its efficacy and safety has not been evaluated in HIV-infected individuals on ART, among whom drug–drug interactions are expected. Day-42 adequate clinical and parasitological response (ACPR) and incidence of adverse events were assessed in HIV-infected individuals on non-nucleoside reverse transcriptase inhibitor-based ART (efavirenz and nevirapine) with uncomplicated P. falciparum malaria treated with dihydroartemisinin–piperaquine.

Methods
An open label single arm clinical trial was conducted in Malawi (Blantyre and Chikhwawa districts) and Mozambique (Manhiça district) involving patients aged 15–65 years with uncomplicated P. falciparum malaria who were on efavirenz-based or nevirapine-based ART. They received a directly-observed 3-day standard treatment of DPQ and were followed up until day 63 for malaria infection and adverse events. Day-42 PCR-corrected-ACPRs (95% confidence interval [CI]) were calculated for the intention-to-treat (ITT) population.

Results
The study enrolled 160 and 61 patients on efavirenz and nevirapine-based ART, with a baseline geometric mean (95% CI) parasite density of 2681 (1964–3661) and 9819 (6606–14,593) parasites/µL, respectively. The day-42 PCR-corrected ACPR (95% CI) was 99.4% (95.6–99.9%) in the efavirenz group and 100% in the nevirapine group. Serious adverse events occurred in 5.0% (8/160) and 3.3% (2/61) of the participants in the efavirenz and nevirapine group, respectively, but none were definitively attributable to DPQ. Cases of prolonged QT interval (> 60 ms from baseline) occurred in 31.2% (48/154) and 13.3% (8/60) of the patients on the efavirenz and nevirapine ART groups, respectively. These were not clinically significant and resolved spontaneously over time. As this study was not designed to compare the efficacy and safety of DPQ in the two ART groups, no formal statistical comparisons were made between the two ART groups.

Conclusions
DPQ was highly efficacious and safe for the treatment of malaria in HIV-infected patients concurrently taking efavirenz- or nevirapine-based ART, despite known pharmacokinetic interactions between dihydroartemisinin–piperaquine and efavirenz- or nevirapine-based ART regimens.
Trial registration Pan African Clinical Trials Registry (PACTR): PACTR201311000659400. Registered on 4 October 2013, https://pactr.samrc.ac.za/Search.aspx
Concordance of Patient and Caregiver Reports on the Quality of Colorectal Cancer Care
Authors: Havyer Rachel D. , van Ryn Michelle , Wilson Patrick M. , Bangerter Lauren R. , Griffin Joan M. 
Published: August 2019

PURPOSE: We aimed to better understand how similarly patients with colorectal cancer and caregivers view care quality and to assess factors that may influence concordance. MATERIALS AND METHODS: We conducted a secondary analysis of paired patient and caregiver quality ratings of colorectal cancer care in three specific domains: surgery, chemotherapy overall, and chemotherapy nursing. Agreement was assessed with difference scores, concordance with Gwet second-order agreement statistics (AC2), and variation in agreement with stratified analyses. We examined whether the care experiences of patients and caregivers were associated with top-box (most-positive) ratings and examined variations in concordance on the basis of the presence of a top-box score. RESULTS: Four hundred seventeen patient-caregiver dyads completed the surveys. Quality-of-care ratings were positively skewed, with most dyads indicating top-box ratings. Patient and caregiver care experiences were highly associated with top-box ratings. Overall patient-caregiver concordance was very high for all three care domains (surgery: AC2, 0.87 [95% CI, 0.83 to 0.90]; chemotherapy overall: AC2, 0.84 [95% CI, 0.79 to 0.88]; chemotherapy nursing: AC2, 0.91 [95% CI, 0.87 to 0.94]). Stratified analyses of patient and caregiver characteristics did not identify any patterns that consistently affected concordance. The concordance statistic significantly decreased for all three outcomes ( P < .001), however, when the patient or caregiver assessed quality as anything other than top box. CONCLUSION: Caregiver and patient reports on care quality were highly concordant for top-box care and did not vary with patient or caregiver factors. Additional exploration is needed to identify reasons for increased variability when the quality scores were less than a top-box response.
The congressional mandate: standardised post-acute care quality measures
Authors: Kroll Christine , Fisher Thomas 
Published: August 2019

Background/Aims This study describes the relationships between rehabilitation services intensity, post-acute care measures of Functional Performance Change, and length of stay for episodes of care provided in 93 skilled nursing facilities in the US. Methods The study used a secondary analysis of existing data on Medicare beneficiaries admitted to skilled nursing facilities from acute hospitals (n=518) who subsequently returned to the community. Data were selected from Minimum Data Set Section GG items reported by therapists. Results Statistically significant correlations were identified between rehabilitation services intensity and functional outcomes (P<0.001); and between rehabilitation intensity, medical condition, and length of stay (P<0.001) for rehabilitation patients in skilled nursing facilities. Conclusions The intensity of occupational and physical rehabilitation therapy services correlate with patients achieving higher functional outcomes, specifically improvement in self-care and mobility.
Histopathological features of patients with chronic granulomatous disease
Authors: Kashani Paria , Chen Haiying 
Published: August 2019

Introduction: Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Affected patients suffer recurrent life-threatening infections due to phagocyte dysfunction and dysregulation of the immune system. Histopathological assessment is important to help identify the extent and severity of infection and tissue injury.Aim: We present pathological findings in 5 patients with CGD who were followed at our centre.Methods: Patient information was reviewed retrospectively in accordance with local institutional guidelines. All patients had confirmed diagnosis of CGD with mutation in one of the 5 subunits of the NADPH oxidase.Results: Histopathological features of the gastrointestinal tract, liver, and spleen are noted, and include the presence of granulomatous inflammation and pigmented macrophages.Discussion: It is essential for clinicians to keep primary immunodeficiency as one of the differential diagnoses in patients with severe infection or inflammation, whether in the absence or presence of granuloma formation. The detection of PAS-positive macrophages, diffuse granulomatous inflammation, and hepatic abscesses should raise strong suspicion of CGD.Statement of novelty: We describe the histopathological findings of a paediatric cohort of patients with CGD.
Interpreting clinical and laboratory tests: importance and implications of context
Authors: Charney Alan N. , Dourmashkin Jordan T. 
Published: August 2019

Abstract
Clinical and laboratory tests in clinical medicine include a range of measurements that may be categorized as “normal range” tests, positive or negative tests, or contextual tests. Normal range test results are quantitative and are compared to a reference interval or range provided by the laboratory. Positive or negative tests are also quantitative tests and characteristically have a cutoff value that specifies the result. Contextual tests require a context, a physiological condition, to correctly interpret the result. A closer examination of reference intervals suggests that these also are contextual. The fact that there is a range of apparently normal values indicates the presence of cultural, biological, physiological and behavioral diversity in the population sampled to determine normality. As such, the reference interval describes the population from which it was determined and may have utility in this regard.
1D Hematite-[α-Fe2O3]-nanorods prepared by green fabrication for supercapacitor electrodes
Authors: Ge Yuru , Hoque Md. Ikram Ul , Qu Qunting 
Published: August 2019

Abstract
1D α-hematite nanorods synthesized by a simple, scalable and novel green chemistry method exhibit fast kinetics of the interfacial Faradaic redox reaction yielding a specific capacitance of 140 F·g−1 when used as a battery-type electrode in a supercapacitor. Ample supply and environmental compatibility of the raw material suggest the use of this material. Insufficient stability suggest further investigations.
Analysis of the preparatory phase of a construction investment in the area covered by revitalization
Authors: Radziejowska Aleksandra , Sagan Joanna 
Published: August 2019

Abstract
The issue of preparing a construction project, especially in the area covered by revitalisation, requires a comprehensive approach and, above all, a multifaceted analysis of the conditions during the programming and planning of the investment. Currently, the majority of investments carried out in the areas covered by the Revitalisation Programme are carried out by public entities, which results from a number of possible risks of failure of the project.
The article presents possible scenarios of administrative proceedings related to planning the implementation of an investment located in the areas covered by the Revitalization Program based on the requirements of legal regulations. A list and the amount of co-financing for the investments carried out so far located in revitalised areas were also presented. Finally, an exemplary SWOT matrix for a private sector investor was proposed, which may support him in the decision to undertake a project in the area covered by the Revitalisation Programme.
Linguistic identity among new speakers of Basque
Authors: Ortega Ane , Urla Jacqueline , Amorrortu Estibaliz , Goirigolzarri Jone , Uranga Belen 
Published: August 2019

Abstract
The increase in Basque speakers in the last 30 years has been due in large part to ‘new speakers’ or euskaldunberri, a term that will be used here to refer to those who have learned the language by means other than family transmission. While very significant in numbers, to date this group has not been the object of much study. Little is known about their attitudes and motivations, how they perceive themselves as Basque speakers, or their language use and transmission patterns. Acquiring answers to these questions is of strategic importance for developing an effective evidence-based language policy for the future. This article presents the results of a qualitative study of new speakers. Drawing on data from focus groups and interviews, the central goal of the article is to examine how new speakers of differing profiles perceive and locate themselves with respect to the popularly used labels for “new” and “native” Basque speakers and the ideologies of authenticity and legitimacy that seem to shape these perceptions. The analysis shows that learning the language alone, even to a high degree of competence, does not guarantee a view of themselves as true and genuine speakers of Basque.
1-(2-Aminoethyl)-3-methyl-1H-imidazol-3-ium tetrafluoroborate: synthesis and application in carbohydrate analysis
Authors: Zhang Yao Y. , Senan Ahmed M. , Wang Ting , Liu Li , Voglmeir Josef 
Published: August 2019

Abstract
Reductive alkylation of the carbonyl group of carbohydrates with fluorescence or ionizing labels is a prerequisite for the sensitive analysis of carbohydrates by chromatographic and mass spectrometric techniques. Herein, 1-(2-aminoethyl)-3-methyl-1H-imidazol-3-ium tetrafluoroborate ([MIEA][BF4]) was successfully synthesized using tert-butyl N-(2-bromoethyl)carbamate and N-methylimidazole as starting materials. MIEA+ was then investigated as a multifunctional oligosaccharide label for glycan profiling and identification using LC-ESI-ToF and by MALDI-ToF mass spectrometry. The reductive amination of this diazole with carbohydrates was exemplified by labeling N-glycans from the model glycoproteins horseradish peroxidase, RNase B, and bovine lactoferrin. The produced MIEA+ glycan profiles were comparable to the corresponding 2AB labeled glycan derivatives and showed improved ESI-MS ionization efficiency over the respective 2AB derivatives, with detection sensitivity in the low picomol to the high femtomol range.
Clinical trial publication trends within neurology
Authors: Q. Duy Phan , Sreekrishnan Anirudh , David Wyatt , Paranjpe Manish D. , Paranjpe Ishan , Sheth Amar , Gültekin Batur , Sheth Kevin N. 
Published: August 2019

Abstract
Timely dissemination of results from clinical studies is crucial for the advancement of knowledge and clinical decision making. A large body of research has shown that up to half of clinical trials do not publish their findings. In this study, we sought to determine whether clinical trial publication rates within neurology have increased over time. Focusing on neurology clinical trials completed between 2008 to 2014, we found that while the overall percentage of published trials has not changed (remaining at approximately 50%), time to publication has significantly decreased. Our findings suggest that clinical trials within neurology are being published in a more timely manner.
A Miniaturized Testing Apparatus to Study the Chemo-Mechanics of Porous Media
Authors: Cil Mehmet B. , Schabelski Jay , Packman Aaron I. , Buscarnera Giuseppe 
Published: August 2019

Abstract
Understanding coupled processes in subsurface systems is critical to assessing and predicting the long-term impacts of natural phenomena, underground industrial activities, and geoengineering. Here, we discuss the capabilities of a new miniaturized chemo-mechanical testing device that allows for concurrent reactive transport, mechanical loading, and microstructural imaging. The apparatus enables a range of combined deformation/flow tests to be performed simultaneously or sequentially. In addition, the device enables controlling reactant mixing, flow rate, and boundary conditions, which is useful to identify key factors in flow-through precipitation and dissolution experiments in porous media. Results of precipitation, oedometric compression, and dissolution tests are presented along with concurrent microstructural analyses based on synchrotron X-ray microtomography imaging. High-resolution 3-D images of evolving microstructural features allow explicit quantification of pore structure changes. The results illustrate the efficiency and versatility of the new multifunctional testing device and emphasize the benefits of quantifying the outcomes of coupled chemo-mechanical processes at pore scale, which is essential to develop and validate multiscale transport-reaction-deformation models.
Comparative Evaluation of Moisture Susceptibility Test Methods for Routine Usage in Asphalt Mixture Design
Authors: DeCarlo Christopher , Dave Eshan V. , Sias Jo E. , Airey Gordon , Mallick Rajib 
Published: August 2019

Abstract
Asphalt materials experience substantial amounts of environmental damage throughout their lives as surface layers in pavements. One of the most prominent forms of environmental damage, moisture-induced damage, is caused by the weakening of internal bonds of the material because of the presence of moisture in the voids of asphalt mixtures and is a common problem for asphalt pavements in wet climates. Moisture-induced damage is typically accounted for during asphalt mixture design by conducting performance tests to ensure the material is not susceptible to severe damage from moisture, although many of these methods have seen mixed amounts of success historically. The main objective of this study is to evaluate the ability of multiple asphalt mixture moisture susceptibility tests to identify good and poor performing mixtures with respect to moisture-induced damage to replace current mix design testing requirements. Ten plant-produced hot mix asphalt materials with established good and poor field moisture performance were subjected to various moisture susceptibility test methods. The results from these procedures are assessed to determine which procedure is most effective and practical as a moisture susceptibility test for routine usage during asphalt mixture design for transportation agencies. Results from this study suggest that performance tests with stiffness-based measurements, such as dynamic modulus paired with moisture conditioning and the saturated aging tensile stiffness procedure, show better correlation to field performance than traditional test methods such as AASHTO T-283, Standard Method of Test for Resistance of Compacted Asphalt Mixtures to Moisture-Induced Damage, and that the Hamburg wheel tracker test is the most effective and practical test method to reliably identify mixtures prone to experiencing moisture-induced damage.