bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial
Authors: Sloekers Jiske Cornelia Theresa , Bos Michael , Hoogland Govert , Bastiaenen Caroline , van Kuijk Sander , Theunissen Maurice , Rijkers Kim , Dings Jim , Colon Albert , Rouhl Rob P W , Schijns Olaf Elisabeth Maria Ghislaine 
Published: September 2019

IntroductionEffective treatment of new-onset headache after craniotomy, especially anterior temporal lobectomy (ATL) and amygdalohippocampectomy for drug-resistant temporal lobe epilepsy, is a challenge. The current practice, acetaminophen combined with opioids is often reported by patients as insufficient and sometimes accompanied by opioid-related adverse effects. Based on expert opinion, anaesthesiologists therefore frequently consider s-ketamine as add-on therapy. This randomised parallel group design trial compares s-ketamine with a placebo as add on medication to a multimodal pain approach.Methods and analysisIn total 62 adult participants, undergoing ATL for drug resistant epilepsy under general anaesthesia, will be randomised to either receive a 0.25 mg/kg bolus followed by a continuous infusion of 0.1 mg/kg/hour of s-ketamine or placebo (0.9% NaCl) starting before incision and continued for 48 hours as an addition to acetaminophen and opioids administered in a patient-controlled analgesia pump. The primary outcome measure is the cumulative postoperative opioid consumption. Patient recruitment started August 2018 and will end in 2021. Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively. All data are collected by researchers who are blinded to the treatment. The data will be analysed by multivariable linear mixed-effects regression.Ethics and disseminationEthical approval has been given by the local medical ethical committee (NL61666.068.17). This study will be conducted in accordance with the Dutch Medical Research Involving Human Subjects Act and the Declaration of Helsinki. The results of this trial will be publicly disclosed and submitted for publication in an international peer-reviewed scientific journal.Trial registration numberNTR6480.
Efficacy and safety of 1C class antiarrhythmic agent (propafenone) for supraventricular arrhythmias in septic shock compared to amiodarone: protocol of a prospective randomised double-blind study
Authors: Balik Martin , Waldauf Petr , Maly Michal , Matousek Vojtech , Brozek Tomas , Rulisek Jan , Porizka Michal , Sachl Robert , Otahal Michal , Brestovansky Petr , Svobodova Eva , Flaksa Marek , Stach Zdenek , Pazout Jaroslav , Duska Frantisek , Smid Ondrej , Stritesky Martin 
Published: September 2019

IntroductionSupraventricular arrhythmias contribute to haemodynamic compromise in septic shock. A retrospective study generated the hypothesis that propafenone could be more effective than amiodarone in achieving and maintaining sinus rhythm (SR). Certain echocardiographic parameters may predict a successful cardioversion and help in the decision on rhythm or rate control strategy.Methods and analysisThe trial includes septic shock patients with new-onset arrhythmia, but without severe impairment of the left ventricular ejection fraction. After baseline echocardiography, the patient is randomised to receive a bolus and maintenance dose of either amiodarone or propafenone. The primary outcome is the proportion of patients that have achieved rhythm control at 24 hours after the start of the infusion. The secondary outcomes are the percentages of patients that needed rescue treatments (DC cardioversion or unblinding and crossover of the antiarrhythmics), the recurrence of arrhythmias, intensive care unit mortality, 28-day and 1-year mortality. In the posthoc analysis, we separately assess subgroups of patients with pulmonary hypertension and right ventricular dysfunction. In the exploratory part of the study, we assess whether the presence of a transmitral diastolic A wave and its higher velocity-time integral is predictive for the sustainability of mechanical SR and whether the indexed left atrial endsystolic volume is predictive of recurrent arrhythmia. Considering that the restoration of SR within 24 hours occurred in 74% of the amiodarone-treated patients and in 89% of the patients treated with propafenone, we plan to include 200 patients to have an 80% chance to demonstrate the superiority of propafenone at p=0.05.Ethics and disseminationThe trial is recruiting patients according to its second protocol version approved by the University Hospital Ethical Board on the 6 October 2017 (No. 1691/16S-IV). The results will be disseminated through peer reviewed publications and conference presentations.Trial registration numberNCT03029169.
Antibodies against citrullinated peptides are associated with clinical and radiological outcomes in patients with early rheumatoid arthritis: a prospective longitudinal inception cohort study
Authors: Boman Antonia , Brink Mikael , Lundquist Anders , Hansson Monica , Mathsson-Alm Linda , Rönnelid Johan , Berglin Ewa , Holmdahl Rikard , Skriner Karl , Serre Guy , Klareskog Lars , Rantapää-Dahlqvist Solbritt 
Published: September 2019

IntroductionAnticitrullinated peptide antibody (ACPA) responses for 22 citrullinated peptides in patients with early rheumatoid arthritis (RA) were analysed and related to radiological and clinical outcome during the first 2 years in a prospective inception cohort.MethodsThe ACPA reactivities were assessed in 1022 patients with early RA (symptoms <12 months) using the custom-made microarray chip (Thermo Fisher Scientific, Uppsala, Sweden) in a prospective longitudinal study of observational assessments of Disease Activity Score (DAS28 and its components) and radiology during the first 24 months, accounting for the treatment.ResultsFrequency of ACPA reactivities varied between 13.3% and 63.1%. Of the anticyclic citrullinated peptide-2 (anti-CCP2) antibody-negative patients, ACPA reactivities were positive in 32.6%. Smoking, human leucocyte antigen-shared epitope (HLA-SE), anti-CCP2/rheumatoid factor, protein tyrosine phosphatase non-receptor type 22 (1858C/T) and DAS28 were significantly associated with number of ACPA reactivities. The ACPA reactivities modified differently the development of DAS28 over 24 months (identified using trajectories). Anti-Filaggrin307-324, anti-hnRNP (Peptide)-Z1 and anti-F4-CIT-R antibodies anticipated lower DAS28 values (p<0.01–0.05), while positivity for anti-Fibrinogen(Fib)β62-78(74), and anti-Fibα563-583 predicted higher DAS28 (p<0.01 both). Interaction between anti-Fibß36-52, anti-Pept-5 and anti-Bla-26 antibodies, respectively, and DAS28 during 24 months decreased significantly the DAS28 values (p<0.01–0.05). Corticosteroids and biologicals were related to DAS28-area under the curve and Larsen score 24 months. Anti-vimentin2-17 antibodies remained significantly associated with Larsen score at baseline and 24 months, respectively, and radiological progression, besides biologicals at 24 months adjusted for sex and age.ConclusionsSeveral ACPA reactivities modified significantly the DAS28 development during the first 24 months and were significantly associated with Larsen score at baseline, 24 months and radiological progression.
NavCog3 in the Wild
Authors: Sato Daisuke , Oh Uran , Guerreiro João , Ahmetovic Dragan , Naito Kakuya , Takagi Hironobu , Kitani Kris M. , Asakawa Chieko 
Published: September 2019

NavCog3 is a smartphone turn-by-turn navigation assistant system we developed specifically designed to enable independent navigation for people with visual impairments. Using off-the-shelf Bluetooth beacons installed in the surrounding environment and a commodity smartphone carried by the user, NavCog3 achieves unparalleled localization accuracy in real-world large-scale scenarios. By leveraging its accurate localization capabilities, NavCog3 guides the user through the environment and signals the presence of semantic features and points of interest in the vicinity (e.g., doorways, shops).
To assess the capability of NavCog3 to promote independent mobility of individuals with visual impairments, we deployed and evaluated the system in two challenging real-world scenarios. The first scenario demonstrated the scalability of the system, which was permanently installed in a five-story shopping mall spanning three buildings and a public underground area. During the study, 10 participants traversed three fixed routes, and 43 participants traversed free-choice routes across the environment. The second scenario validated the system’s usability in the wild in a hotel complex temporarily equipped with NavCog3 during a conference for individuals with visual impairments. In the hotel, almost 14.2h of system usage data were collected from 37 unique users who performed 280 travels across the environment, for a total of 30,200m traversed.
An “EZ” Epigenetic Road to Leukemia Stem Cell Metabolic Reprogramming?
Authors: Li Meng , Melnick Ari M. 
Published: September 2019

Abstract

Summary:
In this issue of Cancer Discovery, Gu and colleagues developed a mouse model of myeloproliferative neoplasm driven by NrasG12D and Ezh2−/−, which cooperated to induce malignant transformation and metabolic reprogramming of leukemic stem cells at least in part through loss of normal epigenetic regulation of gene expression. Furthermore, their findings point to Ezh1 and branched chain amino acid metabolism as biological dependencies and potential therapeutic targets in myeloid neoplasms.
See related article by Gu et al., p. 1228.
Cortical Tracking of Surprisal during Continuous Speech Comprehension
Authors: Weissbart Hugo , Kandylaki Katerina D. , Reichenbach Tobias 
Published: September 2019

Abstract
Speech comprehension requires rapid online processing of a continuous acoustic signal to extract structure and meaning. Previous studies on sentence comprehension have found neural correlates of the predictability of a word given its context, as well as of the precision of such a prediction. However, they have focused on single sentences and on particular words in those sentences. Moreover, they compared neural responses to words with low and high predictability, as well as with low and high precision. However, in speech comprehension, a listener hears many successive words whose predictability and precision vary over a large range. Here, we show that cortical activity in different frequency bands tracks word surprisal in continuous natural speech and that this tracking is modulated by precision. We obtain these results through quantifying surprisal and precision from naturalistic speech using a deep neural network and through relating these speech features to EEG responses of human volunteers acquired during auditory story comprehension. We find significant cortical tracking of surprisal at low frequencies, including the delta band as well as in the higher frequency beta and gamma bands, and observe that the tracking is modulated by the precision. Our results pave the way to further investigate the neurobiology of natural speech comprehension.
A Single-Center Experience of the Optimal Initial Immunosuppressive Strategy for Preventing Early Acute Cellular Rejection in Orthotopic Heart Transplantation Associated With Renal Dysfunction
Authors: Mundisugih Juan , Fernando Himavan , Bergin Peter , Hare James , Kaye David , Leet Angeline , McGiffin David , Taylor Andrew J. 
Published: September 2019

Background: Renal dysfunction is a common complication following heart transplantation that may be worsened by the early initiation of calcineurin inhibitors. Antithymocyte globulin (ATG) or basiliximab has been used to delay or avoid calcineurin inhibitors. The most effective strategy for preventing early acute cellular rejection in this context is uncertain. Methods: We retrospectively reviewed all heart transplant cases between January 2012 and June 2017. The standard therapy consisted of mycophenolate mofetil, prednisolone, and tacrolimus. In patients at high risk of post-transplant renal dysfunction, an early calcineurin inhibitor-free regimen with basiliximab and/or ATG was used. Patients were assigned to cohorts based on the initial immunosuppressive strategy. The primary end point was the freedom rate of acute cellular rejection within 4 weeks post-transplant. Results: Of 93 cases, 21 patients received standard therapy, 64 patients received an initial calcineurin inhibitor-free regimen with basiliximab, and 8 patients received ATG and basiliximab. Freedom from acute rejection was greater in the ATG plus basiliximab group (all rejection free), compared to 40 (63%) of 64 patients treated with basiliximab and 10 (48%) of 21 patients treated with standard therapy ( P < .05, log rank test). In patients treated with basiliximab, early administration (<24 hours) was associated with a higher freedom from acute rejection compared to ≥24 hours, (72% vs 29%, P < .05). Conclusions: The combination of ATG and basiliximab was more effective in preventing acute cellular rejection. In those patients treated with basiliximab, rejection rates were no worse than standard therapy; however, it was only effective when administered within 24 hours.
Association Between Genetic Polymorphisms in Metaloproteinases of the Matrix and Delayed Tooth Emergence: A Cross-sectional Study
Authors: Evangelista Silvane Silva , Arid Juliana , Vasconcelos Katia Regina Felizardo , Cruz Giuseppe Valduga , Dutra André Luiz Tannus , da Silva Lea Assed Bezerra , da Silva Raquel Assed Bezerra , Nelson-Filho Paulo , Vieira Alexandre Rezende , de Queiroz Alexandra Mussolino , Küchler Erika Calvano 
Published: September 2019

Background and Aims: Animal models have been demonstrating that MMPs have an important function in the tooth eruption process. The aim of this study was to evaluate the association between genetic polymorphisms in MMP8 and MMP13 and delayed tooth eruption of permanent teeth. Materials and Methods: This cross-sectional study selected 216 children, 9- to 12-year-old, from public schools at Manaus, Amazonas, Brazil. During oral clinical examination, each permanent tooth emerged in the oral cavity was evaluated. Children were considered with delayed tooth eruption when at least one permanent tooth was delayed and were classified in 2 groups: children “with delayed tooth emergency” and “without delayed tooth emergency.” Saliva samples were collected from DNA extraction. The genetic polymorphisms rs17099443 and rs3765620 in MMP8, and rs478927 and rs2252070 in MMP13 were genotyped. Statistical Analysis: PLINK V1.07 ( http://pngu.mgh.harvard.edu/purcell/plink/ ) and GraphPad Prism 5.0 (San Diego, CA, USA) were used. The c2 or Fisher exact test was used to calculate genotypes and alleles distributions. To compare the mean number of delayed teeth according to genotypes, the Kruskal-Wallis test with multiple comparison Dunn test was used. The established alpha for all comparisons was .05. Results: The polymorphism rs17099443 in MMP8 was associated with delayed tooth eruption in the genotype distribution ( P = .05). In the allele distribution, the C allele was underrepresented in children with delayed tooth eruption ( P = .01; OR = 0.61, 95% confidence interval, 0.41–0.9). Conclusion: The genetic polymorphism rs17099443 in MMP8 is associated with delayed tooth eruption.
Ambidextrous Program Management: The Case of Autonomous Mobility
Authors: Midler Christophe , Maniak Rémi , de Campigneulles Théodore 
Published: September 2019

This article analyzes the management of project portfolios that encompass both exploratory and implementation projects under the denomination of ambidextrous program management. We build on the project/program and ambidexterity literature to characterize such programs. Based on an in-depth three-year study, we apply this analytical framework to an emblematic case: the Autonomous Mobility (AM) initiative of a major automotive firm. We characterize the coordination challenges of such ambidextrous program management, and propose a coordination concept to deal with them, which we term the program hub. Our contribution to the project management field is to extend the scope of analysis to a new type of program that simultaneously coordinates both exploratory and implementation projects. We also advance the ambidexterity field by demonstrating how ambidextrous program management can orchestrate different types of ambidextrous organizational patterns within the firm. For practitioners, we illustrate the multibillion-dollar innovation initiative focused on autonomous mobility that is ongoing within the auto industry.
Prevalence of Helicobacter pylori Infection, Its Virulent Genotypes, and Epstein-Barr Virus in Peruvian Patients With Chronic Gastritis and Gastric Cancer
Authors: Castaneda Carlos A. , Castillo Miluska , Chavez Iván , Barreda Fernando , Suarez Nancy , Nieves Jais , Bernabe Luis A. , Valdivia Daniel , Ruiz Eloy , Dias-Neto Emmanuel , Landa-Baella Maria P. , Bazan Yaqueline , Rengifo Carlos A. , Montenegro Paola 
Published: September 2019

PURPOSE Helicobacter pylori (HP) and Epstein Barr virus (EBV) infections induce chronic gastritis (CG) and are accepted carcinogenics of gastric cancer (GC). Our objective for this study was to determine the prevalence of these agents and clinicopathological features of GC and CG associated with the infection. PATIENTS AND METHODS A single-center cohort of 375 Peruvian patients with GC and 165 control subjects with CG were analyzed. Evaluation of HP and EBV genes was performed through quantitative polymerase chain reaction. RESULTS Prevalence of HP was 62.9% in the whole population and 60.8% in the GC subset. The cagA gene was detected in 79.9%; vacAs1 and vacAm1 alleles in 41.6% and 60.7%, respectively; and concurrent expression of vacAs1 and vacAm1 in 30.4% of infected patients in the whole series. The prevalence of EBV was 14.1% in the whole population and was higher in GC ( P < .001). Coinfection of HP and EBV was found in 7.8% and was also higher in GC in univariate ( P < .001) and multivariate ( P = .011) analyses. Infection rates of HP and EBV were not associated with a geographic location in the whole series. Few clinicopathological features have been associated with infectious status. CONCLUSION Prevalence of HP infection and virulent strains are high in the Peruvian population. Infection by EBV was more frequent in patients with GC.
Ladja: Luta para dançar
Authors: Monteiro Edu 
Published: September 2019

Através de duas pesquisas distintas, separadas por um hiato de oitenta anos, o artigo investiga as transformações decorrentes do processo de ocidentalização na ladja – uma dança de combate embalada pelo canto e o toque do tambor, nascida nas encruzilhadas da diáspora africana na Martinica. Palavras-chave: Ladja. Dança de combate. Diáspora africana. Arte na Martinica. Abstract Through two different researches, separated by a gap of eighty years, the article investigates the transformations resulting from the process of westernization in the ladja – a combat dance performed by the chant and the drumming, born at the crossroads of the African diaspora in Martinique. Keywords: Ladja. Combat dance. African diaspora. Art in Martinique.
Effectiveness of pain education to improve pain related knowledge, attitudes and behaviours in health care students and professionals: a systematic review protocol
Authors: Mankelow Jagjit , Ryan Cormac , Taylor Paul , Simpson Dominic , Martin Denis 
Published: September 2019

Background/Aims Chronic pain is a long-term condition and a leading cause of disability worldwide. The training of health care professionals is where knowledge and attitudes about pain may be shaped for the future. Pain education and management by health care professionals is recognised as being inadequate. This systematic review investigates the effectiveness of biopsychosocial education in improving health care professionals' and students' management of chronic pain. It informs the future delivery of effective pain management education. Methods Biopsychosocial education randomised controlled trials involving health care professionals or students, and measuring changes in knowledge or understanding, attitudes and beliefs or management behaviours in pain, will be included. Comparison studies will feature usual education control, placebo, or a different type of education. Two reviewers will apply two screenings and assess for bias. Statistical analysis of data will be undertaken or discussed in narrative and graphic format if necessary.
TERAPI REALITAS UNTUK MENANGANI TRAUMA (POST TRAUMATIC STRESS DISORDER) PADA KORBAN BULLYING DI BALAI PERLINDUNGAN DAN REHABILITASI SOSIAL WANITA YOGYAKARTA
Authors: Ashofa Nur Hamid 
Published: September 2019

ABSTRACTBullying (violence) has a very negative impact on victims both physically and psychologically. Not all victims of bullying dare to share the problems they are experiencing with others, even though this is very disturbing to the psychic or emotional level of the client. The minimal level of awareness of the surrounding environment is also the reason for the lack of handling victims of bullying. When not getting the right treatment it will be very detrimental to the victims in the future, especially when victims of bullying are underage children. The impact that will be caused is trauma.In this study we will discuss how reality therapy is used to deal with trauma for victims of bullying in the women's social protection and rehabilitation center (BPRSW). This study will also use several other therapies including religious therapy. Because in practice if you only use one theory or only use one theory, it is not very effective to help deal with the trauma experienced by victims of bullying.The choice of subject here is with the approval of the hall, psychologist, and also confirmation to the LS (victim). The data obtained by researchers is derived from the results of interviews with the parties, psychologists, and also victims. From the results of interviews and also conducting observations in the field directly, reality therapy is believed to be used to deal with trauma to victims of bullying even though it requires several other therapies in its application and also requires a short time and more intensive counseling with victims. Keyword: Bullying, Reality Therapy.
WEDI ISIN (TAKUT MALU); AJINING DIRI (HARGA DIRI) ORANG JAWA DALAM PERSPEKTIF WONG CILIK (RAKYAT JELATA)
Authors: Soehadha Moh 
Published: September 2019

This article discuss self-esteem, one of the Javanese attitude. Dignity or self- esteem for the Javanese is part of the humanist character. Self-esteem is related to humanity (kamanungsan), namely the attitude of the self that prioritizes human behavior in treating others. Anthropologically, the Javanese self-esteem can be seen from the concept of local knowledge, which is a form of local knowl- edge that comes from daily life that is still growing in Java. The Javanese emic concept of self-esteem can be transformed into a value of wisdom and the spiri- tual insight on the present, when there is a stagnation in the application of general knowledge that has been dominated by Western values.
SPIRITUALITAS PENGHAYAT AJARAN KAPRIBADEN
Authors: Fauziyah Siti 
Published: September 2019

This paper explores spiritual practices of a Javanese Spiritual Groups in Purworejo, Central Java, namely Kapribaden. Most of the Kapribaden practitioners are religious people who are not satisfied with their own religion and seek a spiritual path that is able to fulfil their spiritual thirstiness in order to find the meaning of life. According to the Kapribaden teaching , the meaning of life can attained be through three ways: First is working hard with responsibility and then receive the result sincerely; second, to behave to others with right action and love; and third, to take spiritual lessons from ever y calamity and suffering through intro- spection for their future better.