bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative and quantitative assessment of infraoccluded deciduous teeth: a systematic review
Authors: Temming Teresa , Waldmann Susanne , Jablonski-Momeni Anahita , Korbmacher-Steiner Heike 
Published: October 2024

Abstract
Background
Infraocclusion of deciduous teeth is a frequent dental anomaly caused by ankylosis accompanied by local growth disturbance. During puberal growth spurt an increasing progression of infraocclusion is detected. The clinical classification of ankylosed deciduous teeth varies considerably among scientific studies. The aim of this paper is to present an up-to-date overview of the variety of methods.

Methods
The systematic literature search followed the PRISMA guidelines and included the analysis of the following databases and study registries: PubMed (MEDLINE), the Cochrane Library, Web of Science, Embase.com and ClinicalTrials.gov from database inception until September 23, 2024. Studies that investigated at least one ankylosed deciduous tooth per participant in a quantitative or qualitative manner were included. Studies that evaluated only histological data were excluded. Controlled and uncontrolled clinical studies, retrospective studies, observational studies and cross-sectional studies were included. The studies were restricted to English and German languages. Case reports, case series, comments, expert opinions, letters to the editor, literature reviews and studies enrolling less than 10 patients or 10 infraoccluded teeth in total were excluded.

Results
Of 5645 records, 42 papers qualified for the final analysis. The evaluation of infraoccluded deciduous teeth was mainly (n = 37) performed by quantitative and semiquantitative assessment of the extent of infraposition at the occlusal level. The measurement reference differed considerably. Fewer studies have analyzed ankylosed deciduous teeth at the alveolar level by examining the contour of the alveolar ridge (n = 7) or the height of the alveolar process (n = 5). Even fewer studies (n = 4) have performed qualitative analysis at the skeletal level by evaluating the influence of the vertical skeletal growth pattern on the incidence of ankylosed deciduous teeth.

Conclusions
To carry out a comprehensive evaluation of infraoccluded deciduous teeth, an assessment of the occlusal, alveolar and potentially skeletal levels is advisable. Radiographic investigations i.e. panoramic radiographs are therefore essential as a supplement to clinical examination. There is a need for standardization and objectification of the methods for the classification of infraoccluded deciduous teeth to give a general recommendation of clinical performance.

Registration
This systematic review has been registered in the international prospective register of systematic reviews (PROSPERO) under the registration number: CRD42024555842.
Optimization of a rapid, sensitive, and high throughput molecular sensor to measure canola protoplast respiratory metabolism as a means of screening nanomaterial cytotoxicity
Authors: Osmani Zhila , Islam Muhammad Amirul , Wang Feng , Meira Sabrina Rodrigues , Kulka Marianna 
Published: October 2024

AbstractNanomaterial-mediated plant genetic engineering holds promise for developing new crop cultivars but can be hindered by nanomaterial toxicity to protoplasts. We present a fast, high-throughput method for assessing protoplast viability using resazurin, a non-toxic dye converted to highly fluorescent resorufin during respiration. Protoplasts isolated from hypocotyl canola (Brassica napus L.) were evaluated at varying temperatures (4, 10, 20, 30 ˚C) and time intervals (1–24 h). Optimal conditions for detecting protoplast viability were identified as 20,000 cells incubated with 40 µM resazurin at room temperature for 3 h. The assay was applied to evaluate the cytotoxicity of silver nanospheres, silica nanospheres, cholesteryl-butyrate nanoemulsion, and lipid nanoparticles. The cholesteryl-butyrate nanoemulsion and lipid nanoparticles exhibited toxicity across all tested concentrations (5-500 ng/ml), except at 5 ng/ml. Silver nanospheres were toxic across all tested concentrations (5-500 ng/ml) and sizes (20–100 nm), except for the larger size (100 nm) at 5 ng/ml. Silica nanospheres showed no toxicity at 5 ng/ml across all tested sizes (12–230 nm). Our results highlight that nanoparticle size and concentration significantly impact protoplast toxicity. Overall, the results showed that the resazurin assay is a precise, rapid, and scalable tool for screening nanomaterial cytotoxicity, enabling more accurate evaluations before using nanomaterials in genetic engineering.
Effect of therapeutic plasma exchange on tissue factor and tissue factor pathway inhibitor in septic shock
Authors: Stahl Klaus , Lehner Georg F. , Wendel-Garcia Pedro David , Seeliger Benjamin , Pape Thorben , Schmidt Bernhard M. W. , Schenk Heiko , Schmitt Julius , Sauer Andrea , Wild Lennart , Peukert Konrad , Putensen Christian , Bode Christian , Joannidis Michael , David Sascha 
Published: October 2024

Abstract
Background
Coagulopathy is part of the pathological host response to infection in sepsis. Higher plasma concentrations of both tissue factor (TF) and tissue factor pathway inhibitor (TFPI) are associated with occurrence of disseminated intravascular coagulation (DIC), multi-organ dysfunction and increased mortality in patients with sepsis. Currently no treatment approaches specifically targeting this axis are available. We hypothesize that therapeutic plasma exchange (TPE) might limit this coagulopathy by restoring the balance of plasma proteins.

Methods
This was a pooled post-hoc biobank analysis including 51 patients with early (shock onset < 24 h) and severe (norepinephrine dose > 0.4 μg/kg/min) septic shock, who were either receiving standard of care treatment (SOC, n = 14) or SOC + one single TPE (n = 37). Plasma concentrations of TF and TFPI were measured both at- and 6 h after study inclusion. The effect of TPE on concentrations of TF and TFPI was investigated and compared to SOC patients. Further, baseline TF and TFPI concentrations were used to modulate and predict clinical response to adjunctive TPE, indicated by longitudinal reduction of lactate concentrations over the first 24 h following study inclusion.

Results
TPE led to a significant reduction in circulating concentrations of both TF and TFPI while no difference was observed in the SOC group. Relative change of TF within 6 h was + 14 (-0.8 to + 30.4) % (p = 0.089) in the SOC and −18.3 (−32.6 to −2.2) % (p < 0.001) in the TPE group (between group p < 0.001). Similarly, relative change of TFPI was + 14.4 (−2.3 to + 30.9) % (p = 0.076) in the SOC and −20 (−32.8 to −7.9) % (p < 0.001) in the TPE group (between group p = 0.022). The ratio of TF to TFPI remained unchanged in both SOC and TPE groups. SOC patients exhibited an increase in lactate over the initial 24 h when TF and TFPI concentrations were higher at baseline. In contrast, patients undergoing TPE experienced a sustained longitudinal reduction of lactate concentrations across all levels of baseline TF and TFPI elevations. In a multivariate mixed−effects model, higher baseline TF (p = 0.003) and TFPI (p = 0.053) levels led to greater longitudinal lactate concentration reduction effects in the TPE group.

Conclusions
Adjunctive TPE in septic shock is associated with a significant removal of both TF and TFPI, which may contribute to the early hemodynamic improvement observed in septic shock patients receiving TPE. Higher baseline TF (and TFPI) plasma concentrations were identified as a putative predictor of treatment response that could be useful for predictive enrichment strategies in future clinical trials.
Characterization of gut microbiota dynamics in an Alzheimer’s disease mouse model through clade-specific marker-based analysis of shotgun metagenomic data
Authors: Favero Francesco , Re Angela , Dason Mohammed Salim , Gravina Teresa , Gagliardi Mara , Mellai Marta , Corazzari Marco , Corà Davide 
Published: October 2024

AbstractAlzheimer’s disease (AD) is a complex neurodegenerative disorder significantly impairing cognitive faculties, memory, and physical abilities. To characterize the modulation of the gut microbiota in an in vivo AD model, we performed shotgun metagenomics sequencing on 3xTgAD mice at key time points (i.e., 2, 6, and 12 months) of AD progression. Fecal samples from both 3xTgAD and wild-type mice were collected, DNA extracted, and sequenced. Quantitative taxon abundance assessment using MetaPhlAn 4 ensured precise microbial community representation. The analysis focused on species-level genome bins (SGBs) including both known and unknown SGBs (kSGBs and uSGBs, respectively) and also comprised higher taxonomic categories such as family-level genome bins (FGBs), class-level genome bins (CGBs), and order-level genome bins (OGBs). Our bioinformatic results pinpointed the presence of extensive gut microbial diversity in AD mice and showed that the largest proportion of AD- and aging-associated microbiome changes in 3xTgAD mice concern SGBs that belong to the Bacteroidota and Firmicutes phyla, along with a large set of uncharacterized SGBs. Our findings emphasize the need for further advanced bioinformatic studies for accurate classification and functional analysis of these elusive microbial species in relation to their potential bridging role in the gut-brain axis and AD pathogenesis.
A fuzzy comprehensive evaluation method for assessing the damage degree of cultural relics based on an improved AHP-EWM coupled weight model and a modified ridge function
Authors: Guo Anqi , He Peiling , Min Qing , Xu Shuqiang 
Published: October 2024

Abstract
Due to long-term exposure to outdoor environments, stone artifacts exhibit complex and varying degrees of disease that need to be conserved urgently in order to perpetuate their historical, artistic and scientific values. Owing to the varying degrees of damage inflicted upon cultural relics, discrepancies exist in intervention strategies and conservation materials employed. Hence, it is considerably crucial to conduct a scientific and precise assessment of the preservation status of cultural relics at an early stage for the advancement of cultural relic conservation efforts. In this research, three masonry components of the Hailongtun Fortress site were selected as study objects. A secondary fuzzy comprehensive evaluation system was established through selecting a total of 12 indicators from four aspects, namely, surface change, rock mass structure, physical properties and matrix weathering. The weight of each indicator was determined by using an improved AHP-EWM weight coupling model. The membership degree was calculated by selecting a modified ridge function. The asymmetric nearness method was employed in the final decision-making process so as to correct the error caused by the principle of maximum membership degree. The research shows that the results of the improved evaluation method are in line with the real damage degree of each masonry component, which provides a scientific and quantitative basis for determining the priority of the conservation of masonry components in the Hailongtun Fortress Site. This method is also a reference for carrying out the disease assessment and conservation of other types of cultural relics.
Icariin is a potential neurodegenerative candidate against ammonia–glutamate excitotoxicity–oxidative stress pathway
Authors: Zahra Mai M. , Ali Elham H. A. , Sabry Hend A. 
Published: October 2024

Abstract
Background
Hepatic encephalopathy (HE) is a pathological state characterized by the abrupt or chronic failure of the liver. This study intends to conduct a comparative analysis of potential benefits of icariin (ICA), a primary component of flavonoids found in the Chinese medicinal plant Epimedium, with silymarin (SLY) as a hepatic and brain support agent in a model of HE rats, focusing on assessment of the behavioral and biochemical effects. Thioacetamide (TAA) was given intraperitoneally to rats at a dosage of 200 mg/kg on three separate days to induce HE. Oral gavage of silymarin or ICA (100 mg/kg) was given daily for 14 days following HE induction. All rats underwent behavioral assessments (open field and Y maze). Estimates were made for hepatic functions and brain cortex oxidative stress indicators as well as cytochrome c and caspase-3.

Results
The findings demonstrated that the administration of ICA to rodents with HE induced by TAA led to a recovery of hepatic enzymes activities and behavioral adjustments as shown by an improvement in locomotor and memory functions. Furthermore, Icariin demonstrated a reduction in cortex biochemical indicators through the amelioration of hyperammonemia and enhancement of antioxidant status. This was achieved by reducing malondialdehyde, calcium, nitric oxide contents and downregulating lactate dehydrogenase activities. In addition, ICA maintains alteration of glutamate and glutamine contents.

Conclusion
ICA suggested to possess the capacity to serve as a beneficial hepatotherapeutic and neurotherapeutic adjunct in brain disorders associated with hyperammonemia–glutamate-mediated excitotoxicity.
Comparative mitochondrial genomics of Thelebolaceae in Antarctica: insights into their extremophilic adaptations and evolutionary dynamics
Authors: Mi Zechen , Su Jing , Yu Liyan , Zhang Tao 
Published: October 2024

AbstractSpecies of Antarctomyces and Thelebolus (Thelebolaceae), primarily found in Antarctic environments, exhibit psychrophilic adaptations, yet their mitochondrial genomes have not been extensively studied. Furthermore, few studies have compared the mitochondrial genomes of psychrophilic, psychrotrophic, and mesophilic fungi. After successful sequencing and assembly, this study annotated the mitochondrial genomes of Antarctomyces psychrotrophicus CPCC 401038 and Thelebolus microsporus CPCC 401041. We also performed a comparative analysis with the previously characterized mitochondrial genomes of psychrotrophic and mesophilic fungi. The analysis revealed that nad4L was the most conserved gene across the mitochondrial genomes, characterized by its synonymous and non-synonymous substitution rates (Ks and Ka), genetic distance, and GC content and skew within the protein-coding genes (PCGs). Additionally, the mitochondrial genomes of psychrophilic and psychrotrophic fungi showed a higher proportion of protein-coding regions and a lower GC content compared to those of mesophilic fungi, underscoring the genetic basis of cold adaptation. Phylogenetic analyses based on these mitochondrial genes also confirmed the phylogenetic relationships of Thelebolaceae in the class Leotiomycetes. These findings advance our understanding of the phylogenetic relationships and evolutionary dynamics within the family Thelebolaceae, highlighting how different environmental temperatures influence fungal mitochondrial genomic structure and adaptation.
Verbal feedback for written assessment: evaluating a novel feedback communication strategy
Authors: Singleton Gillian , Furber Christine 
Published: October 2024

Background/Aims Feedback plays a pivotal role in learning, but traditional written feedback often lack engagement and specificity, hindering learners' ability to effectively apply feedback. In midwifery education, the need for innovative feedback delivery mechanisms is pronounced. The aim of this study was to evaluate the integration of digital health technologies in feedback delivery in a midwifery programme. Methods A novel communication strategy was implemented in a midwifery programme in northwest England, where the benefits, challenges and future implications of leveraging digital health technologies for assessment feedback were assessed. Results Preferences were mixed, with 45.1% of learners favouring written feedback. Verbal feedback was perceived as more personal and motivating, and valued for its nuance, tone and ability to clarify complex points, although written feedback provided clearer, detailed information for future reference. Less experienced markers struggled with verbal feedback, while more experienced markers appreciated the quicker, more refreshing process. All markers found feedback templates helpful for ensuring equitable feedback. Conclusions This study scrutinised the significance of rethinking feedback delivery in midwifery education and indicates that digital health technologies present promising opportunities for reshaping the feedback landscape. Implications for practice Developing student confidence and competence in digital literacy remains a significant challenge. Higher education institutions can collaborate with healthcare providers to offer training in digital health technologies, helping midwives adapt to modern clinical environments.
British and American Musical Theatre Exchanges in the West End (1924–1970): The ‘Americanization’ of Drury Lane, Arianne Johnson Quinn (2022)
Authors: Neuhauser Hannah 
Published: October 2024

Review of: British and American Musical Theatre Exchanges in the West End (1924–1970): The ‘Americanization’ of Drury Lane, Arianne Johnson Quinn (2022)
London: Palgrave Macmillan, 283 pp.,
ISBN 978-3-03114-662-6, p/bk, $119.99
Security Challenges and Solutions in SD-WAN Deployments
Authors: Oluyede Michael Sanya , Mart Joseph , Olusola Akinbusola , Olatuja Gabriel 
Published: October 2024

Abstract
Enterprise wide area network (WAN) is a private network that connects the computers and other devices across an organisation’s branch locations and the data centers. It forms the backbone of enterprise communication. Currently, multiprotocol label switching (MPLS) is commonly used to provide this service. As a recent alternative to MPLS, software-defined wide area networking (SDWAN) solutions are being introduced as an IP based cloud-networking service for enterprises. SD-WAN virtualizes the networking service and eases the complexity of configuring and managing the enterprise network by moving these tasks to software and a central controller. The introduction of new technologies causes concerns about their security. Also, this new solution is introduced as a replacement for MPLS, which has been considered secure and has been in use for more than 16 years. Thus, there is a need to analyze the security of SDWAN, which is the goal of this thesis.
In this thesis, we perform a security analysis of a commercial SD-WAN solution, by finding its various attack surfaces, associated vulnerabilities and design weaknesses. We choose Nuage VNS, an SD-WAN product provided by Nuage Networks, as the analysis target. As a result, many attack surfaces and security weaknesses were found and reported, especially in the Customer Premises Equipment (CPE). In particular, we found vulnerabilities in the CPE’s secure bootstrapping method and demonstrated some attacks by exploiting them. Finally, we propose mitigation steps to avoid the attacks.
The results of this thesis will help both the service provider and the SD-WAN solution vendor to know about the attack surfaces and weaknesses of SD-WAN before offering it to their customers. We also help in implementing the temporary countermeasures to mitigate the attacks. The results have been presented to the service provider and the vendor of the SDWAN product.
Peat Water Treatment Using Modified Red mud
Authors: Ivontianti Wivina Diah , Shalindry Riysan Octy , Maleiva Lalak Tarbiyatun Nasyin 
Published: October 2024

Red mud is an alumina refinery waste residue that has been used to develop an effective adsorbent for wastewater treatment, one of which can be applied to peat water. Peat water treatment is carried out using the adsorption method. This study sought to ascertain the impact of the acid types of acid HCl and H2SO4 solution on dealumination process to the characteristics of the red mud adsorbent based on the analysis of XRF and BET instruments. In addition, this study was to determine the effect of the effect of mass variations of the red mud adsorbent on the effectiveness of peat water treatment. This research was conducted on a laboratory scale using variations in the adsorbent mass of 1 g; 3 g ; 5 g and 7 g and variation of contact time used was 15, 30, 60, and 90 minutes . The results showed an increase in the Si/Al ratio from 1.064% to 1.697% for HCl, while for H2SO41.565%. Increasing of surface area with HCl was 179.574% while using H2SO4 was 162.891%. The results of research on the adsorption process with variations in the mass of the adsorbent 1, 3, 5, and 7 grams obtained the results of peat water pH respectively were 6.6; 7.0; 7.0; and 7,1. In the Fe metal there were removal of 73.39%; 37.09%; 24.19% and -141.93%. Then for the organic matter removal efficiency were 53.07%; 50%; 44.30% and -17.98% respectively. In variation of contact time for the parameter Fe, there were removals of 29,03%, 27,41%, and 24,19% respectively. Then for organic matter the removal efficiencies were 32,46%, 54,82%, 48,25%, and 44,29%. The optimum condition based on the result obtained are the 5 g for the mass adsorbent and 30 minute for contact time. Keywords: adsorbent; dealumination; H2SO4; HCl; peat water; red mud.
Measuring Going Concern Viability and the Effect of Interim Financing Under the Indian Insolvency and Bankruptcy Code, 2016
Authors: Agarwal Anant , Varma Jayanth R. 
Published: October 2024

Abstract
India’s insolvency framework mandates preserving viable firms as going concerns, but a critical gap remains – the lack of a standardised approach to assessing a firm’s viability during bankruptcy proceedings, resulting in inefficient allocation of interim finance to insolvent firms. This study sheds light on this issue by examining the performance of 21 firms during insolvency. We find that the absence of a clear viability assessment has led to suboptimal outcomes: viable firms being underfinanced and unviable firms being overfinanced. This has led to value deterioration, as many viable firms were ultimately pushed into liquidation due to insufficient interim financing. As a remedy, the authors propose a periodic viability assessment framework, for collecting and publishing information about the insolvent firm during insolvency proceedings. This would improve transparency and predictability for viable firms seeking interim finance, empowering lenders and investors to make better-informed decisions. By supporting viable distressed firms, this framework could foster a thriving market for distressed debt in India, rescuing valuable companies from the bankruptcy abyss.
Cumulative Tariff Cost Rate and Structure in the Global Value Chain: A Theoretical and Empirical Study
Authors: Ni Hongfu 
Published: October 2024

Abstract
This paper constructs a more unified measurement framework from the perspective of the Leontief inverse matrix and Ghosh inverse matrix (Ghosh). At the same time, referring to the four-term decomposition method of Leontief inverse matrix in Muradov (2016), this paper analyzes the structural decomposition of the cumulative tariff cost rate. Results show that (1) Overall, from 2000 to 2017, China’s cumulative tariff cost rate, direct tariff cost rate, and multi-stage tariff cost rate all showed a downward trend, and the decline was greater than that of other countries (regions). China has strictly fulfilled its WTO accession commitments and has greatly reduced the tariff rate on imported intermediate goods. (2) With China’s deep participation in the global value chain, the amplification effect of China’s tariffs has increased from 2.57 in 2000 to 3.17 in 2017, and there is a certain degree of “amplification effect” (above 1.5) in tariffs in all countries in the world. (3) From the perspective of the contribution rate of various countries in the world, China contributes the most to the global cumulative tariff cost rate, which is due to the complexity of the global production network structure, rather than the excessively high tariff rate imposed by China on imported intermediate goods. In terms of policy implications, if China did not take the initiative to reduce tariffs, the structural changes in the global production network would lead to a larger global cumulative tariff cost rate.