bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of Porous Microparticles Based on Chitosan and Methacrylic Monomers
Authors: Vasiliu Silvia , Lungan Maria‐Andreea , Gugoasa Ionela , Drobota Mioara , Popa Marcel , Mihai Marcela , Racovita Stefania 
Published: August 2019

AbstractStarting from glycidyl methacrylate, three dimethacrylic monomers (mono, di and triethylene glycol dimethacrylate) and chitosan, various types of porous microparticles were obtained by suspension polymerization technique. Also, using the same technique the un‐grafted porous microparticles were obtained by reaction between glycidyl methacrylate and dimethacrylic monomers. The successful grafting reaction of chitosan onto synthetic polymer networks was highlighted by FTIR spectroscopy, scanning electron microscopy, atomic force microscopy and thermogravimetric analysis. The dimensional analysis of all type of microparticles was performed by laser diffraction while the specific surface areas were determined by means of dynamic vapor sorption. Grafting of polysaccharide onto crosslinked networks has led to the preparation of polymeric materials with high specific surface area (50‐160 m2/g) and better swelling capacities (101‐106%) compared to microparticles based on glycidyl methacrylate and dimethacrylic monomers [(31‐69 m2/g) and (39‐57%), respectively]. Furthermore, the sorption properties of grafted and un‐grafted microparticles were tested using Cu(II) solution. The highest retention capacity value of Cu(II) (41.7 mg/g) was obtained when the C1 microparticles were used in the adsorption studies.
Punching resistance of slab‐column connections with openings
Authors: Augustin Tomas , Fillo Ludovit , Halvonik Jaroslav 
Published: August 2019

AbstractThe paper deals with the punching resistance of flat slabs with openings adjacent to a column. The results of an experimental campaign carried out at a laboratory of the Slovak University of Technology in Bratislava (STU) are presented in the paper. A total of eight slabs with a thickness of 250 mm and without transverse reinforcement were tested under axis‐symmetric conditions. The six slabs had two symmetrically placed openings with different distances measured from the column's periphery and two reference slabs did that not have any openings. The results obtained were compared with punching resistances assessed using the design equations introduced in Eurocode 2, Model Code 2010, ACI 318‐14, and the CSCT model expressed in a closed form. Significant differences in the values of the Vtest/VR,c ratio were observed for the different positions of the openings for each design model. In order to increase the accuracy of the models, some changes in estimating the reduced lengths of the control perimeter were proposed.
Extracellular dopamine kinetic parameters consistent with amphetamine effects
Authors: Felmer Anna C. , Janson Marnie T. , Summers Katherine E. , Wallace Lane J. 
Published: August 2019

AbstractPublished behavioral experiments document that amphetamine‐induced increases in locomotor activity are preserved or enhanced in animals with major depletions of stored dopamine but intact dopamine synthesis. Conversely, amphetamine effects are substantially attenuated after inhibition of dopamine synthesis when most of the dopamine stores are preserved. Such data suggest that amphetamine mobilizes newly synthesized dopamine into extracellular signaling space. The first goal of this project is to determine kinetic parameters of dopamine secretion into and removal from extracellular space compatible with the majority of amphetamine‐elicited increases in extracellular dopamine deriving from newly synthesized dopamine. The strategy uses a computational model of extracellular space surrounding a single dopamine varicosity. Model output was compared to published micro‐dialysis data for effects of amphetamine on levels of extracellular dopamine. A family of solutions was found, characterized by a biphasic dose–response relationship for rate of dopamine release. Maximum rates of dopamine release occurred at doses of 0.5–1.0 mg/kg amphetamine. The second goal is to develop a hypothesis by which newly synthesized dopamine gains access to extracellular space. The model chosen involves amphetamine‐induced shunting of DOPAC secretion to dopamine secretion into extracellular space. The quality of the hypothesis was evaluated by goodness of match of model output to published data for amphetamine alone and after inhibition of dopamine synthesis or storage. In summary, the results provide conditions required for and a potential mechanism for newly synthesized dopamine to be a major fraction of amphetamine‐elicited increases in extracellular dopamine.
Timing of Perioperative Chemotherapy Does Not Influence Long‐Term Outcome of Patients Undergoing Combined Laparoscopic Colorectal and Liver Resection in Selected Upfront Resectable Synchronous Liver Metastases
Authors: Ratti Francesca , Fuks David , Cipriani Federica , Gayet Brice , Aldrighetti Luca 
Published: August 2019

AbstractBackgroundThe aim of this study was to compare patients undergoing combined colorectal and hepatic surgery with and without neoadjuvant chemotherapy to clarify the prognostic advantage of preoperative oncological treatment in a case‐matched analysis using propensity scores and to identify factors predictive of good prognosis in a selected population of Synchronous ColoRectal Liver Metastases (SCRLM).MethodsA total of 73 patients who underwent upfront elective combined surgery without preoperative CT for SCRLM in two European tertiary referral centers were selected and constituted the study group (NoNACT group). The NoNACT group was matched (ratio 1:1) with patients who were operated after chemotherapy with neoadjuvant intent (NACT group, the control group). The matching was achieved based on six covariates representative of patients and disease characteristics.ResultsWhile the characteristics of both colorectal and hepatic procedures were similar, the NoNACT group, as compared to the NACT group, had lower blood loss (200 mL vs. 550 mL). Postoperative stay (9 vs. 12 days) and morbidity rate (24.7% vs. 32.9%) were reduced in the NoNACT compared with the NACT group. Mid‐ and long‐term outcomes were comparable. At multivariable analysis, predictors of long‐term outcome were: right colonic neoplasms, RAS mutational status, CRS score ≥3 and the absence of perioperative chemotherapy.ConclusionPreoperative neoadjuvant chemotherapy in patients with colorectal cancer and synchronous resectable liver metastases does not influence the risk of recurrence in patients with favorable tumor biology, while it was associated with increased intraoperative blood loss and morbidity. There is no strong evidence to recommend upfront chemotherapy in the absence of negative prognostic factors.
Implementing interventions to reduce work-related stress among health-care workers: an investment appraisal from the employer’s perspective
Authors: Wijnen Ben F. M. , Lokkerbol Joran , Boot Cecile , Havermans Bo M. , van der Beek Allard J. , Smit Filip 
Published: August 2019

Abstract
Purpose
The Stress-Prevention@Work implementation strategy has been demonstrated to be successful in reducing stress in employees. Now, we assess the economic return-on-investment to see if it would make for a favourable business case for employers.

Methods
Data were collected from 303 health-care workers assigned to either a waitlisted control condition (142 employees in 15 teams) or to Stress-Prevention@Work (161 employees in 15 teams). Main outcome was productivity losses measured using the Trimbos and iMTA Cost questionnaire in Psychiatry. Measurements were taken at baseline, 6, and 12 months post-baseline.

Results
The per-employee costs of the strategy were €50. Net monetary benefits were the benefits (i.e., improved productivity) minus the costs (i.e., intervention costs) and were the main outcome of this investment appraisal. Per-employee net benefits amounted to €2981 on average, which was an almost 60-fold payout of the initial investment of €50. There was a 96.7% likelihood for the modest investment of €50 to be offset by cost savings within 1 year. Moreover, a net benefit of at least €1000 still has a likelihood of 88.2%.

Conclusions
In general, there was a high likelihood that Stress-Prevention@Work offers an appealing business case from the perspective of employers, but the employer should factor in the additional per-employee costs of the stress-reducing interventions. Still, if these additional costs were as high as €2981, then costs and benefits would break even.
This study was registered in the Netherlands National Trial Register, trial code: NTR5527.
Systematic analysis of long non-coding RNA and mRNA expression changes in ApoE-deficient mice during atherosclerosis
Authors: Lou Xiaoqian , Ma Xiaoyan , Wang Dawei , Li Xiangjun , Sun Bo , Zhang Tong , Qin Meng , Ren Liqun 
Published: August 2019

AbstractAtherosclerosis plays an important role in the pathology of coronary heart disease, cerebrovascular disease, and systemic vascular disease. Long non-coding RNAs (lncRNAs) are involved in most biological processes and are deregulated in many human diseases. However, the expression alteration and precise role of lncRNAs during atherosclerosis are unknown. We report here the systematic profiling of lncRNAs and mRNAs in an ApoE-deficient (ApoE−/−) mouse model of atherosclerosis. Clariom D solutions for the mouse Affymetrix Gene Chip were employed to analyze the RNAs from control and ApoE−/− mice. The functions of the differentially expressed mRNAs and lncRNAs and the relationships of their expression with atherosclerosis were analyzed by gene ontology, co-expression network, pathway enrichment, and lncRNA target pathway network analyses. Quantitative real-time PCR (QRT-PCR) was used to determine the expression of mRNAs and lncRNAs. A total of 2212 differentially expressed lncRNAs were identified in ApoE−/− mice, including 1186 up-regulated and 1026 down-regulated lncRNAs (|FC| ≥ 1.1, p < 0.05). A total of 1190 differentially expressed mRNAs were found in the ApoE−/− mice with 384 up-regulated and 806 down-regulated (|FC| ≥ 1.1, p < 0.05). Bioinformatics analyses demonstrated extensive co-expression of lncRNAs and mRNAs and concomitant deregulation of multiple signaling pathways associated with the initiation and progression of atherosclerosis. The identified differentially expressed mRNAs and lncRNAs as well as the related signaling pathways may provide systematic information for understanding the pathogenesis and identifying biomarkers for the diagnosis, treatment, and prognosis of atherosclerosis.
Skin and Proximity Effects in Electrodes and Furnace Shells
Authors: Herland Egil Vålandsmyr , Sparta Manuel , Halvorsen Svenn Anton 
Published: August 2019

Abstract
A review of two-dimensional (2D) analytical models of skin and proximity effects in large industrial furnaces with three electrodes arranged in an equilateral triangle is given. The models cover three different cases: one electrode only, three electrodes where two are approximated by line currents, and induced shell currents where all electrodes are approximated by line currents. The first two models show how the skin and proximity effects depend on electrode material properties and size, and the distance between the electrodes. The third model shows how the strength of the induced shell currents will depend on electrode position and furnace size. These models are compared to numerical studies including distributed electrodes and shell currents. The analytical models are accurate when induced shell currents can be disregarded. However, strong shell currents may have a significant impact on the current distribution within the electrodes. This electrode-shell proximity effect competes with the electrode-electrode proximity effect. Finally, the 2D models have been compared with three-dimensional (3D) case studies of large industrial furnaces. In 3D, the shell currents are significantly smaller than what are predicted by the 2D models, but they are sufficiently strong to cause a significant correction of the electrode current density.
Data-driven approach for evaluation of formation damage during the injection process
Authors: Shabani Ali , Jahangiri Hamid Reza , Shahrabadi Abbas 
Published: August 2019

AbstractWaterflooding is among the most common oil recovery methods which is implemented in the most of oil-producing countries. The goal of a waterflooding operation is pushing the low-pressure remained oil of reservoir toward the producer wells to enhance the oil recovery factor. One of the important objects of a waterflooding operation management is understanding the quality of connection between the injectors and the producers of the reservoir. Capacitance resistance model (CRM) is a data-driven method which can estimate the production rate of each producer and the connectivity factor between each pair of wells, by history matching of the injection and production data. The estimated connectivity factor can be used for understanding the quality of connection between the wells. In the waterflooding operation, the injected water always has the potential of causing formation damage by invasion of foreign particles deep bed filtration (DBF), mobilization of indigenous particles (fines migration), scale formation, etc. The formation damage can weaken the quality of connection (connectivity factor), between the injectors and producers of the field, increasing the skin of injection well. In this paper, DBF is used for creation of formation damage in synthetic reservoir models. Then, it has been tried to find the existence and amount of formation damage by evaluating the connectivity factor of CRM. Finally, the results of that have been used for prediction of skin variation in a real case by using the connectivity factor of CRM.
Unraveling the Mesozoic and Cenozoic Tectonothermal Evolution of the Eastern Basque‐Cantabrian Zone–Western Pyrenees by Low‐Temperature Thermochronology
Authors: DeFelipe I. , Pedreira D. , Pulgar J. A. , van der Beek P. A. , Bernet M. , Pik R. 
Published: August 2019

AbstractLow‐temperature thermochronology studies have increased our knowledge of the orogenic processes along the Pyrenean‐Cantabrian mountain belt by placing time constraints on the exhumation history of its rocks. However, a significant gap in the data existed between the western Pyrenees and the central Cantabrian Mountains, hampering a comprehensive view of the tectonothermal evolution along the belt. We present a new apatite fission track and zircon (U‐Th)/He (ZHe) data set for the eastern Basque‐Cantabrian zone–western Pyrenees. Apatite fission track central ages cluster in the Eocene‐Oligocene. ZHe samples can be separated into two groups: Group 1 depicts clustered ZHe ages‐eU concentration (Cinco Villas massif) and Group 2 depicts dispersed ZHe ages‐eU concentration (Alduides massif and a Paleozoic rock pinned along the Leiza thrust). A sample from the Oroz‐Betelu massif shows intermediate behavior. Inverse modeling suggests that samples from Group 1 reached 240–280 °C in the Late Cretaceous, implying deep sedimentary burial of the Cinco Villas massif before its major exhumation phase, most probably in the early to middle Eocene, postdating the phase of rapid exhumation of the western part of the Leiza thrust. The sample from the Oroz‐Betelu massif, far from the Mesozoic exhumed mantle domain, experienced maximum temperatures close to 200 °C by burial beneath the Jaca‐Pamplona basin. It was later exhumed in the hanging wall of the Gavarnie thrust in the Bartonian‐Priabonian. This work provides new insights into the tectonothermal evolution of the Basque massifs and the inversion of a hyperextended margin.
An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A
Authors: Miura Ryu , Araki Atsuko , Minatoya Machiko , Miyake Kunio , Chen Mei-Lien , Kobayashi Sumitaka , Miyashita Chihiro , Yamamoto Jun , Matsumura Toru , Ishizuka Mayumi , Kubota Takeo , Kishi Reiko 
Published: August 2019

AbstractExposure to bisphenol A (BPA) in utero is associated with adverse health outcome of the offspring. Differential DNA methylation at specific CpG sites may link BPA exposure to health impacts. We examined the association of prenatal BPA exposure with genome-wide DNA methylation changes in cord blood in 277 mother-child pairs in the Hokkaido Study on Environment and Children’s Health, using the Illumina HumanMethylation 450 BeadChip. We observed that a large portion of BPA-associated differentially methylated CpGs with p-value < 0.0001 was hypomethylated among all newborns (91%) and female infants (98%), as opposed to being hypermethylated (88%) among males. We found 27 and 16 CpGs with a false discovery rate (FDR) < 0.05 in the analyses for males and females, respectively. Genes annotated to FDR-corrected CpGs clustered into an interconnected genetic network among males, while they rarely exhibited any interactions in females. In contrast, none of the enrichment for gene ontology (GO) terms with FDR < 0.05 was observed for genes annotated to the male-specific CpGs with p < 0.0001, whereas the female-specific genes were significantly enriched for GO terms related to cell adhesion. Our epigenome-wide analysis of cord blood DNA methylation implies potential sex-specific epigenome responses to BPA exposure.
Diagnóstico precoce da infecção articular periprotética do quadril – situação atual, avanços e perspectivas
Authors: Gomes Luiz Sérgio Marcelino 
Published: August 2019

ResumoA infecção articular periprotética (IAP) tem consequências devastadoras sobre a função articular e sobre a taxa de morbimortalidade dos pacientes vitimados por esta grave complicação. Ainda que o diagnóstico precoce seja um dos consensos com importância bem estabelecida, as rotinas de investigação são ainda conduzidas de forma empírica, inconsistente e pouco objetiva em muitos centros de todo o mundo. O presente artigo busca contextualizar a situação atual dos conhecimentos sobre o diagnóstico precoce das infecções articulares periprotéticas, assim como discutir os avanços e perspectivas, dentro de um cenário de sua aplicabilidade rotineira pela equipe médica responsável pelo manejo desta temida complicação.
Intrauterine Device Insertion during Cesarean Section in Women without Prenatal Contraception Counseling: Lessons from a Country with High Cesarean Rates
Authors: Zaconeta Alberto Moreno , Oliveira Ana Carolina , Estrela Flavielly Souza , Vasconcelos Thalia Maia , França Paulo Sergio , Wanderley Miriam da Silva , Amato Angelica Amorim 
Published: August 2019

Objective The moment of admission for delivery may be inappropriate for offering an intrauterine device (IUD) to women without prenatal contraception counseling. However, in countries with high cesarean rates and deficient prenatal contraception counseling, this strategy may reduce unexpected pregnancies and repeated cesarean sections.
Methods This was a prospective cohort study involving 100 women without prenatal contraception counseling. Postplacental IUD was offered after admission for delivery and placed during cesarean. The rates of IUD continuation, uterine perforation, and endometritis were assessed at 6 weeks and 6 months, and the proportion of women continuing with IUD at 6 months was assessed with respect to the number of previous cesareans.
Results Ninety-seven women completed the follow-up. The rate of IUD continuation was 91% at 6 weeks and 83.5% at 6 months. The expulsion/removal rate in the first 6 weeks was not different from that between 6 weeks and 6 months (9 vs 9.1%, respectively). There were 2 cases of endometritis (2.1%), and no case of uterine perforation. Among 81 women continuing with intrauterine device after 6-months, 31% had undergone only the cesarean section in which the IUD was inserted, 44% had undergone 2 and 25% had undergone 3 or more cesarean sections.
Conclusion Two thirds of the women who continued with IUD at 6 months had undergone 2 or more cesarean sections. Since offering trial of labor is unusual after 2 or more previous cesareans, we believe that offering IUD after admission for delivery may reduce the risk of repeated cesarean sections and its inherent risks.
Three new flavonol glycosides from Fissistigma pallens
Authors: Nhiem Nguyen Xuan , Thinh Ngo Sy , Thu Nguyen Thi Bich , Anh Luu The , Minh Ngoc Tran , Tai Bui Huu , Yen Pham Hai , Kiem Phan Van , Van Minh Chau , Park Seonju , Kim Seung Hyun 
Published: August 2019

ABSTRACT
Three new flavonol glycosides, fissflavosides A-C (1–3), together with six known flavonol glycosides, kaempferol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-galactopyranoside (4), kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside (5), kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (6), rhamnetin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (7), rutin (8), and isorhamnetin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-galactopyranoside (9) were isolated from the methanol extract of the Fissistigma pallens leaves. Their chemical structures were determined by 1D-, 2D-NMR, and MS data as well as in comparison with reported data in the literature. Compounds 1–9 showed weak cytotoxic activity on three human cancer cell lines, HT-29, A-2058, A-549 with IC50 ranging from 134.6 to 162.6 µM. In addition, the antioxidant capacities of compounds were also tested by ORAC assay. All compounds showed significant antioxidant with trolox equivalents ranging from 4.4 to 8.6 µM at the concentration of 1.0 µM. The results indicated 7 and 8 having meaningful reducing capacity of copper (I) ions of 2.7 to 6.9 µM at the concentrations of 1 and 2 µM.
Surgery performed at night by continuously working surgeons contributes to a higher incidence of intraoperative complications in video-assisted thoracoscopic pulmonary resection: a large monocentric retrospective study
Authors: Chen Chunji , Zhang Xiaofeng , Gu Chang , Wang Yiyang , Liu Kun , Pan Xufeng , Fu Shijie , Fan Limin , Wang Rui 
Published: August 2019

Abstract

OBJECTIVES
Our goal was to assess the influence of working hours and working at night on intraoperative complications on surgeons conducting video-assisted pulmonary resections.

METHODS
We identified all patients who underwent video-assisted thoracoscopic surgery (VATS) in Shanghai Chest Hospital from January 2015 to April 2017. Univariable and multivariable logistic analyses were used to analyse independent risk factors for intraoperative complications. A 1:4 propensity score matching analysis was conducted to verify those results.

RESULTS
A total of 15 767 patients who underwent VATS pulmonary resection were included in this study. Among them, 15 280 patients (96.1%) were operated on during daytime working hours and 487 (3.1%) at night. A total of 203 (1.3%) intraoperative complications occurred. Vascular injury was the main cause of intraoperative complications, accounting for 92.1% (187/203). Multivariable logistic regression indicated that age [odds ratio (OR) = 1.68, 95% confidence interval (CI) 1.43–1.98; P < 0.001], gender (OR = 1.71, 95% CI 1.26–2.32; P = 0.001), surgical experience (OR = 2.07, 95% CI 1.56–2.75; P < 0.001), type of surgery (OR = 0.31, 95% CI 0.20–0.49; P < 0.001) and operative periods (OR = 2.69, 95% CI 1.61–4.86; P < 0.001) were independent predictors for intraoperative complications. The incidence of intraoperative complications during night-time surgery was significantly higher than that during daytime working hours. A 1:4 propensity score matching-based results verification showed that night-time surgery was still an independent risk factor after propensity score matching (OR = 2.76, 95% CI 1.47–5.15; P = 0.002).

CONCLUSIONS
The incidence of intraoperative complications from VATS pulmonary resection performed during night hours was significantly higher than that performed during working hours. In the present labour environment, thoracic surgeons should avoid night-time surgery whenever possible.