bluuebunny/crossref_metadata_2025_split huggingface dataset:
The hemodynamic effects of a central iliac arteriovenous anastomosis at 6 months in patients with resistant and uncontrolled hypertension
Authors: Eysenck William , van Zalen Jet , Freemantle Nick , Lloyd Guy , Furniss Stephen , Sulke Neil 
Published: July 2019

AbstractA central iliac arteriovenous anastomosis, termed the “coupler” (ROX Medical), results in a significant reduction in blood pressure (BP) in hypertensive patients. This study assessed functional and hemodynamic changes induced by the device. Twenty‐one patients with resistant and/or uncontrolled hypertension underwent stress echocardiography and cardiopulmonary exercise testing (CPET) at baseline and 6 months post‐coupler implantation. End points were selected to best evaluate cardiac function including Doppler stroke volume (SV), septal and lateral E/E′, and right ventricular systolic velocity S′ (RV S′). CPET VO2 peak demonstrated total cardiopulmonary performance. SV increased from 76.4 SD12.2 mL to 92.1 SD22.7 mL 6 months post‐coupler insertion; P = .002. No changes in RV S′, septal or lateral E/E′, or VO2 peak were observed. Five patients experienced increased diuretic requirement ≥3 times baseline. RV S′ fell from 19.0 SD1.87 cm/s to 16.80 SD3.43 cm/s in these patients (P > .05). A significant increase in SV 6 months post‐coupler insertion was observed. In patients with increased diuretic requirement, the device was associated with a lower RV S′ suggesting occult RV dysfunction as the mechanism of this pre‐specified adverse outcome.
Early restoration of immune and vascular phenotypes in systemic lupus erythematosus and rheumatoid arthritis patients after B cell depletion
Authors: Pérez‐Sánchez Carlos , Cecchi Irene , Barbarroja Nuria , Patiño‐Trives Alejandra M. , Luque‐Tévar María , Pérez‐Sánchez Laura , Ibáñez‐Costa Alejandro , Arias de la Rosa Iván , Ortega Rafaela , Escudero Alejandro , Castro María Carmen , Radin Massimo , Roccatello Dario , Sciascia Savino , Aguirre María Ángeles , Collantes Eduardo , López‐Pedrera Chary ,   BIOSAR Study Group
Published: July 2019

AbstractThis translational multi‐centre study explored early changes in serologic variables following B lymphocyte depletion by rituximab (RTX) treatment in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients and investigated in vitro effects on the activity of other immune cells and the vascular endothelium. Eighty‐five SLE patients, seventy‐five RA patients and ninety healthy donors were enrolled. Two additional cohorts of selected SLE and RA patients were treated with RTX for 3 months. Changes in circulating levels of inflammatory mediators, oxidative stress markers and NETosis‐derived bioproducts were evaluated. Serum miRNomes were identified by next‐generation sequencing, and RTX‐induced changes were delineated. Mechanistic in vitro studies were performed to assess activity profiles. Altered inflammatory, oxidative and NETosis‐derived biomolecules were found in SLE and RA patients, closely interconnected and associated to specific miRNA profiles. RTX treatment reduced SLE and RA patients' disease activity, linked to a prominent alteration in those biomolecules and the reversal of altered regulating miRNAs. In vitro studies showed inhibition of NETosis and decline of pro‐inflammatory profiles of leucocytes and human umbilical vein endothelial cells (HUVECs) after B cell depletion. This study provides evidence supporting an early RTX‐induced re‐setting of the pro‐inflammatory status in SLE and RA, involving a re‐establishment of the homeostatic equilibrium in immune system and the vascular wall.
Not everything is as it seems: commentary on ‘Stereophotogrammetric three‐dimensional photography is an accurate and precise planimetric method for the clinical visualization and quantification of human papilloma virus‐induced skin lesions’
Authors: Skerlev M. , Ljubojević Hadžavdić S. , Sirotković‐Skerlev M. 
Published: July 2019

Linked article: M. Rijsbergen et al. J Eur Acad Dermatol Venereol 2019; 33: 1506–1512. https://doi.org/10.1111/jdv.15474.
The susceptibility of silver crucian carp (Carassius auratus langsdorfii) to infection with koi herpesvirus (KHV)
Authors: Kim Hyoung Jun , Kwon Se Ryun , Olesen Niels Jørgen , Yuasa Kei 
Published: July 2019

AbstractKoi herpesvirus (KHV) infections cause high mortality in carp (Cyprinus carpio). This study compared the susceptibility of silver crucian carp (Carassius auratus langsdorfii), also called ginbuna, and koi carp to KHV infection. Silver crucian carp and koi carp were challenged with KHV by both intraperitoneal injection and immersion, respectively, and kept in tanks at 22°C. All KHV‐exposed koi carp died within 14 days post‐infection (dpi), whereas no clinics nor mortality was observed in the KHV‐exposed silver crucian carp. KHV DNA was detected in both koi and silver crucian carp shortly after infection. At 7 dpi, the copy numbers of KHV genome were increased in koi carp but decreased in silver crucian carp. Using reverse transcriptase PCR, KHV mRNA was detected in koi carp but not in silver crucian carp. Cell cultivation on common carp brain (CCB) cell samples from koi carp caused KHV‐associated cytopathic effects in CCB cells. Therefore, we concluded that KHV replicated in koi carp but not in silver crucian carp and that silver crucian carp is not susceptible to infection with KHV.
Improved oxidative stability of peanut oil through addition of finger millet (Eleusine coracana) seed coat polyphenols
Authors: Balasubramaniam Velur Geetha , Sathvika Saravanapandian , Ayyappan Palaniappan , Antony Usha 
Published: July 2019

AbstractThe effect of polyphenols from finger millet seed coat (FMSC) on the oxidative stability of refined peanut oil (RPO) and unrefined peanut oil (UPO), at different concentrations and storage conditions was compared with butylated hydroxytoluene (BHT). A significant dose‐dependent reduction of oxidation in RPO compared with UPO was observed. FMSC polyphenols at 800 ppm inhibited oxidation equivalent to BHT (200 ppm), while at 1000 ppm, FMSC effectively reduced the peroxide value (5.1 ± 0.3 and 9.5 ± 0.5 meq/kg oil), acid value (0.97 ± 0.3 and 1.16 ± 0.4 KOH/g), and Thiobarbituric acid reactive species (TBARS) (18.08 ± 0.39 and 20.32 ± 0.56 mg MDA/kg) in RPO and UPO, respectively, during regular storage (RS; 28 ± 5°C, 7 weeks). Oxidative deterioration was higher in terms of all parameters in the oils during accelerated conditions (AS; 65 ± 5°C, 6 days). The Rancimat induction time confirmed the stability of both RPO and UPO in the presence of polyphenols. Regular storage up to 7 weeks and accelerated storage (AS) up to 3rd day (equivalent to 3 months) were achieved with FMSC polyphenols (1,000 ppm), confirming its potential as a natural antioxidant in vegetable oils.Practical applicationsPeanut oil contains high levels of PUFA that are susceptible to lipid oxidation leading to rancidity and off flavors. The food industry relies largely on synthetic antioxidants such as butylated hydroxytoluene (BHT), butylated hydroquinone (BHQ) and tert‐butyl hydro quinine (TBHQ) to inhibit deterioration caused by fats; however synthetic compounds have shown toxic effects. The study demonstrates the ability of finger millet polyphenols in delaying oxidation in both refined and unrefined peanut oils. Millet polyphenols as potential antioxidants in lipid food systems have the added advantage of providing food safety while maintain quality.
Beyond the unions: The Pembillai Orumai women's strike in the south Indian tea belt
Authors: Raj Jayaseelan 
Published: July 2019

AbstractThe article examines an extraordinary wildcat strike led by women tea workers against a giant tea plantation company and dominant trade unions in the south Indian tea belt of Munnar. It employs situational analysis to examine the larger processes that led to the strike, implications for the workers, and to the wider socio‐economic relations in the tea belt. It is argued here that in addition to the exploitative plantation production and the poor implementation of welfare measures, the strike was largely fuelled by and directed against union corruption and the breach by union leaders of egalitarian relations in the workers' society. At the end, the article calls for an understanding of local conceptions of inequality, injustice, and humiliation as forces that have the potency to initiate and intensify labour resistance under exploitative production relations.
Facial rejuvenation using Er:YAG laser equipped with a spatially modulated ablation module: A clinical, ultrasound, and histological evaluation
Authors: Volkova Natalia V. , Valamina Irene E. , Shvidun D. V. , Rebrieva A. S. , Sadick Neil S. 
Published: July 2019

AbstractBackgroundA plethora of noninvasive approaches has been developed in recent years for facial rejuvenation. Energy‐based devices have been one of the most popular treatments for reversing and preventing signs of facial aging such as fine lines, wrinkles, ptosis, and photoaging.AimsA new technology (RecoSMA) for skin rejuvenation based on acoustic‐interference method using Er:YAG laser (2936 nm) equipped with a special module that targets both the dermis and the superficial musculoaponeurotic system (SMAS) was recently demonstrated to be safe and effective in facial rejuvenation.Patient/MethodsIn this follow‐up prospective study, the clinical effects of recoSMA treatment on skin structures and SMAS were evaluated with ultrasound and histological analysis, at 30 and 90 days posttreatment.ResultsTreatment with recoSMA was shown to result in a significant increase in thickness of the epidermis, dermis, and SMAS layer, while levels of collagen I, III, and IV were shown to be elevated at 90 days posttreatment.ConclusionCollectively, data show that treatment with recoSMA laser has a profound biological effect in stimulating and reconstructing the elastin/collagen framework necessary for preventing facial aging.
A cleanser formulated with Tris (hydroxymethyl) aminomethane andl‐arginine significantly improves facial acne in male Thai subjects
Authors: Kumtornrut Chanat , Manabe Siyarat Dilokphongyotin , Navapongsiri Marut , Okutani Yuri , Ikegaki Shinichi , Tanaka Noriyuki , Hashimoto Hiroshi , Songsantiphap Chankiat , Wantavornprasert Kittipong , Khamthara Jenvajee , Takagi Yutaka , Asawanonda Pravit 
Published: July 2019

AbstractBackgroundAcne is one of the most common skin problems among human populations. A facial cleanser formulated with alkyl ether carboxylate (AEC) and alkyl carboxylate (AC) can improve acne by cleansing sebum on facial skin but cannot effectively remove keratotic plugs in the skin pores. Recently, we confirmed that Tris (hydroxymethyl) aminomethane and L‐arginine (Tris/Arg) is able to reduce sebum levels, disrupt keratotic plugs in vitro and decrease pore size on facial skin.ObjectiveTo compare the efficacy of the Tris/Arg‐formulated cleanser with the AEC/AC cleanser in Thai subjects with acne.MethodsWe designed a randomized, double‐blind, controlled, parallel trial. Thirty‐four male Thai subjects with mild to moderate acne were assigned to one of two groups: one group used the Tris/Arg cleanser while the other used the AEC/AC‐based cleanser twice a day for 4 weeks.ResultsAfter 4 weeks, significant decreases in noninflammatory acne were observed in both groups, yet significant decreases in inflammatory acne were only observed in the Tris/Arg cleanser group. The sebum level prior to and 30 minutes after facial washing showed no change in either group. The average pore size with keratotic plugs on the cheeks was significantly decreased in the Tris/Arg group. More than half of subjects in both groups observed acne improvement but more subjects in the Tris/Arg group noted pore size improvement.ConclusionThe Tris/Arg formulated cleanser has a high efficacy for significantly reducing both noninflammatory and inflammatory acne accompanied by decreases in pore size with keratotic plugs in male Thai subjects.
Myelin Water Atlas: A Template for Myelin Distribution in the Brain
Authors: Liu Hanwen , Rubino Cristina , Dvorak Adam V. , Jarrett Michael , Ljungberg Emil , Vavasour Irene M. , Lee Lisa Eunyoung , Kolind Shannon H. , MacMillan Erin L. , Traboulsee Anthony , Lang Donna J. , Rauscher Alexander , Li David K.B. , MacKay Alexander L. , Boyd Lara A. , Kramer John L.K. , Laule Cornelia 
Published: July 2019

ABSTRACTBACKGROUND AND PURPOSEMyelin water imaging (MWI) is a magnetic resonance imaging technique that quantifies myelin in‐vivo. Although MWI has been extensively applied to study myelin‐related diseases in groups, clinical use in individual patients is challenging mainly due to population heterogeneity. The purpose of this study was twofold: (1) create a normative brain myelin water atlas depicting the population mean and regional variability of myelin content; and (2) apply the myelin atlas to assess the degree of demyelination in individuals with multiple sclerosis (MS).METHODS3T MWI was performed on 50 healthy adults (25 M/25 F, mean age 25 years [range 17‐42 years]). The myelin water atlas was created by averaging coregistered myelin water fraction (MWF) maps from all healthy individuals. To illustrate the preliminary utility of the atlas, white matter (WM) regional MWF variations were evaluated and voxel‐wisez‐score maps (z< −1.96) from the MWI of three MS participants were produced to assess individually the degree of demyelination.RESULTSThe myelin water atlas demonstrated significant MWF variation across control WM. No significant MWF differences were found between male and female healthy participants. MSz‐score maps revealed diffuse regions of demyelination in the two participants with Expanded Disability Status Scale (EDSS) = 2.0 but not in the participant with EDSS = 0.CONCLUSIONSThe myelin water atlas can be used as a reference (URL:https://sourceforge.net/projects/myelin-water-atlas/) to demonstrate areas of demyelination in individual MS participants. Future studies will expand the atlas age range, account for education, and other variables that may affect myelination.
Length–weight relationships of four indigenous fish species collected in Assam and Meghalaya, India
Authors: Kaushik Gitartha , Synnah Kduplin , Tariang Kermi‐u , Narayana Ramanujam Sunkam , Bordoloi Sabitry 
Published: July 2019

AbstractThe length–weight relationships (LWRs) of four indigenous fish species; namely Parambassis baculis (Hamilton, 1822); Pethia gelius (Hamilton, 1822); Channa stewartii (Playfair, 1867); and Leiodon cutcutia (Hamilton, 1822) collected from the Ranganadi River in Assam, and the Simsang and Kynshi River in Meghalaya are presented in the present study. The value of the parameter b recorded for P. baculis = 3.347; P. gelius = 3.924; C. stewartii = 2.979; and L. cutcutia = 3.205, with regression coefficients (r2) of 0.993, 0.963, 0.983 and 0.955, respectively. Parameter a was 0.0124 for P. baculis, 0.0037 for P. gelius, 0.0098 for C. stewartii and 0.0273 for L. cutcutia. As information on the LWRs of these fish species is not available in the FishBase database, it should assist future researchers to better analyse the stock of these fishes.
Xylem–phloem hydraulic coupling explains multiple osmoregulatory responses to salt stress
Authors: Perri Saverio , Katul Gabriel G. , Molini Annalisa 
Published: July 2019

Summary

Salinity is known to affect plant productivity by limiting leaf‐level carbon exchange, root water uptake, and carbohydrates transport in the phloem. However, the mechanisms through which plants respond to salt exposure by adjusting leaf gas exchange and xylem–phloem flow are still mostly unexplored.

A physically based model coupling xylem, leaf, and phloem flows is here developed to explain different osmoregulation patterns across species. Hydraulic coupling is controlled by leaf water potential, ψl, and determined under four different maximization hypotheses: water uptake (1), carbon assimilation (2), sucrose transport (3), or (4) profit function – i.e. carbon gain minus hydraulic risk. All four hypotheses assume that finite transpiration occurs, providing a further constraint on ψl.

With increasing salinity, the model captures different transpiration patterns observed in halophytes (nonmonotonic) and glycophytes (monotonically decreasing) by reproducing the species‐specific strength of xylem–leaf–phloem coupling. Salt tolerance thus emerges as plant's capability of differentiating between salt‐ and drought‐induced hydraulic risk, and to regulate internal flows and osmolytes accordingly.

Results are shown to be consistent across optimization schemes (1–3) for both halophytes and glycophytes. In halophytes, however, profit‐maximization (4) predicts systematically higher ψl than (1–3), pointing to the need of an updated definition of hydraulic cost for halophytes under saline conditions.
Strategies to reduce attrition in weight loss interventions: A systematic review and meta‐analysis
Authors: Pirotta Stephanie , Joham Anju , Hochberg Lisa , Moran Lisa , Lim Siew , Hindle Annemarie , Brennan Leah 
Published: July 2019

SummaryThe primary objective of the study was to identify the effect of intervention strategies on attrition within a weight loss programme among adults aged 18 to 65 years. The secondary objective of the study was to assess the impact of such intervention strategies among female‐only weight loss programmes. The literature search was performed in Ovid (CINAHL Plus, MEDLINE, EMBASE, Cochrane [Cochrane Database of Reviews, Cochrane Central Register of Controlled Trials, and Cochrane Methodology Register], and PsycINFO). Studies must have identified weight loss as the main aim and compared the primary weight loss programme alone (control) with the primary weight loss programme coupled with an additional intervention strategy (intervention). Papers must have had a mean participant age between 18 and 65 years and available in English. Fifty‐seven trials met the inclusion criteria and were included in the meta‐analysis. Strategies that successfully reduced attrition included the incorporation of financial incentives (n = 8), a multicomponent approach (n = 13), and use of self‐monitoring technology (n = 4). The majority of studies were of low to moderate methodological quality because of insufficient reporting. A limited number of female‐only trials were found (n = 13). Implementation of financial incentives, multicomponent interventions, and self‐monitoring technology help reduce attrition among adult weight loss programmes. Further studies are required to identify the impact of intervention strategies on attrition in women.
Key stakeholders' perspectives on the development of a national transfer document, for older persons, when transferring between the residential and acute care settings: A qualitative descriptive study
Authors: O'Reilly Pauline , O'Brien Brid , Graham Margaret M. , Murphy Jill , Barry Louise , Doody Owen , Fahy Anne , Hoey Carmel , Kiely Michelle , Lang Deirdre , Meskell Pauline , O'Doherty Jane , O'Keefe Jonathon , Tuohy Dympna , Coffey Alice 
Published: July 2019

AbstractAims and objectivesThis study has aimed to examine key stakeholders' perspectives, views and experiences regarding transfer documents, used when an older person is being transferred from a residential to an acute care setting. The objective of the study was to inform, in part, the development of an effective national transfer document.BackgroundFor the effective and safe transfer of older persons from residential to acute care settings, it is important to ensure that the transfer document encapsulates relevant, current and person‐centred information to ensure a smooth, quality and safe transition. Evidence highlights that, where documentation has lacked vital and relevant information, the older persons experience negative impacts during the transfer process.DesignA qualitative descriptive study was conducted, following the COREQ checklist, to establish participants' perspectives, views and experiences of using transfer documents.MethodsFocus group interviews (n = 8) were conducted with a convenience sample of key stakeholders (n = 68) in an Irish setting. The data were analysed using content analysis.ResultsThe findings have highlighted the important aspects for consideration in the development of future transfer documentation. The three broad categories, used to present the data findings, are (a) existing transfer documentation; (b) design framework; and (c) essentials of care.ConclusionsThe transfer document of the future is required to be concise, regularly reviewed and with a user‐friendly colour‐coded design. Essential and current information, with an emphasis on person centeredness, must be in the first page, with more detailed supporting information in the subsequent sections.
Priming and filtering of antiherbivore defences among Nicotiana attenuata plants connected by mycorrhizal networks
Authors: Song Yuanyuan , Wang Ming , Zeng Rensen , Groten Karin , Baldwin Ian T. 
Published: July 2019

AbstractArbuscular mycorrhizal fungi (AMF) establish symbiotic associations with a majority of terrestrial plants to form underground common mycorrhizal networks (CMNs) that connect neighbouring plants. Because Nicotiana attenuata plants do not respond to herbivory‐elicited volatiles from neighbours, we used this ecological model system to evaluate if CMNs function in interplant transmission of herbivory‐elicited responses. A mesocosm system was designed to establish and remove CMNs linking N. attenuata plants to examine the herbivory‐elicited metabolic and hormone responses in CMNs‐connected “receiver” plants after the elicitation of “donor” plants by wounding (W) treated with Manduca sexta larval oral secretions (OS). AMF colonization increased constitutive jasmonate (JA and JA‐Ile) levels in N. attenuata roots but did not affect well‐characterized JAs‐regulated defensive metabolites in systemic leaves. Interestingly, larger JAs bursts, and higher levels of several amino acids and particular sectors of hydroxygeranyllinalool diterpene glycoside metabolism were elevated in the leaves of W + OS‐elicited “receivers” with CMN connections with “donors” that had been W + OS‐elicited 6 hr previously. Our results demonstrate that AMF colonization alone does not enhance systemic defence responses but that sectors of systemic responses in leaves can be primed by CMNs, suggesting that CMNs can transmit and even filter defence signalling among connected plants.
Bayesian Variable Selection Using Spike-and-Slab Priors with Application to High Dimensional Electroencephalography Data by Local Modelling
Authors: Mohammed Shariq , Dey Dipak K. , Zhang Yuping 
Published: July 2019

SummaryBecause of the immense technological advances, very often we encounter data in high dimensions. Any set of measurements taken at multiple time points for multiple subjects leads to data of more than two dimensions (a matrix of covariates for each subject). We present a Bayesian variable-selection method to identify the active regions in the brain as a response to a certain stimulus. We build binary classification models of subject level responses by using binary regression with Gaussian models on the latent variables. We also study the scaled normal priors on the latent variables, as they cover a large family of distributions. We use continuous spike-and-slab priors to incorporate variable selection within the modelling. Because of the computational complexity, we build many local (at different time points) models and make predictions by utilizing the temporal structure between the local models. We perform two-stage variable selection for each of these local models. We demonstrate the effectiveness of such modelling through the results of a simulation study. We then present the performance of these models on multisubject neuroimaging (electroencephalography) data to study the effects on the functional states of the frontal cortex and parietal lobe for chronic exposure of alcohol.