bluuebunny/crossref_metadata_2025_split huggingface dataset:
Signatures of recent positive selection in enhancers across 41 human tissues
Authors: Moon Jiyun M. , Capra John A. , Abbot Patrick , Rokas Antonis 
Published: January 2019

AbstractEvolutionary changes in enhancers are widely associated with variation in human traits and diseases. However, studies comprehensively quantifying levels of selection on enhancers at multiple evolutionary time points during recent human evolution and how enhancer evolution varies across human tissues are lacking. To address these questions, we integrated a dataset of 41,561 transcribed enhancers active in 41 different human tissues (FANTOM Consortium) with whole genome sequences of 1,668 individuals from the African, Asian, and European populations (1000 Genomes Project). Our analyses based on four different metrics (Tajima’s D, FST, H12, nSL) showed that ~5.90% of enhancers considered showed evidence of recent positive selection and that genes associated with enhancers under positive selection are enriched for diverse immune-related functions. The distributions of these metrics for brain and testis enhancers were often statistically significantly different compared to those of other tissues; the same was true for brain and testis enhancers that are tissue-specific compared to those that are tissue-broad and for testis enhancers associated with tissue-enriched and non-tissue-enriched genes. These differences varied considerably across metrics and tissues and were generally due to changes in distributions’ shapes rather than shifts in their values. These results suggest that many human enhancers experienced recent positive selection throughout multiple time periods in human evolutionary history, that this selection occurred in a tissue-dependent and immune-related functional context, and that much like the evolution of their coding counterparts, the evolution of brain and testis enhancers has been markedly different from that of enhancers in other tissues.
GAMer 2: A System for 3D Mesh Processing of Cellular Electron Micrographs
Authors: Lee Christopher T. , Laughlin Justin G. , Beaumelle Nils Angliviel de La , Amaro Rommie E. , McCammon J. Andrew , Ramamoorthi Ravi , Holst Michael J. , Rangamani Padmini 
Published: January 2019

AbstractObjectiveRecent advances in electron microscopy have, for the first time, enabled imaging of single cells in 3D at a nanometer length scale resolution. An uncharted frontier for in silico biology is the ability to simulate cellular processes using these observed geometries. However, this will require a system for going from EM images to 3D volume meshes which can be used in finite element simulations.MethodsIn this paper, we develop an end-to-end pipeline for this task by adapting and extending computer graphics mesh processing and smoothing algorithms. Our workflow makes use of our recently rewritten mesh processing software, GAMer 2, which implements several mesh conditioning algorithms and serves as a platform to connect different pipeline steps.ResultsWe apply this pipeline to a series of electron micrographs of dendrite morphology explored at three different length scales and show that the resultant meshes are suitable for finite element simulations.ConclusionOur pipeline, which consists of free and open-source community driven tools, is a step towards routine physical simulations of biological processes in realistic geometries.SignificanceWe posit that a new frontier at the intersection of computational technologies and single cell biology is now open. Innovations in algorithms to reconstruct and simulate cellular length scale phenomena based on emerging structural data will enable realistic physical models and advance discovery.
The role of autonomy, competence and relatedness
Authors: Ahn Jiseon , Back Ki-Joon 
Published: January 2019

PurposeThis study aims to apply the perspective of self-determination theory to investigate the effects of needs satisfaction on customers’ emotional bond and perceived fit with the integrated resort brand.Design/methodology/approachTo provide empirical evidence, this study uses an online survey analyzed with structural equation modeling.FindingsThe results suggest how integrated resort experiences enhance the needs satisfaction for autonomy, competence and relatedness, and that customers are likely to have an attachment and compatibility with the brand. This study also documents that strong attachments and compatibility are predictive of behavioral intention.Research limitations/implicationsThis study provides a theoretical perspective through self-determination theory for explaining how needs satisfaction impacts customers’ brand-related attitude, which can be used to guide future studies. Insights from this research will be used to design and evaluate customers’ experience in tourism and hospitality industry.Originality/valueAlthough the concept of needs satisfaction has studied on the employees’ behavior, a scarcity of research has been offered to explain customers’ behavior. Thus, this study makes a significant contribution to the hospitality and tourism research by testing the needs satisfaction as an antecedent of customers’ brand-related behavior.
Ethics in third sector–school partnerships: a conceptual framework
Authors: Eyal Ori , Berkovich Izhak 
Published: January 2019

PurposeIn recent years, third sector–school partnerships have become more common and received increasing research attention. Yet, the ethical aspects of third sector–school partnerships have not been discussed in-depth. As a result, the field lacks a conceptual framework that makes possible in-depth understanding of the ethical characteristics involved in partnerships between public schools and the third sector. The purpose of this paper is to fill this lacuna.Design/methodology/approachAn integrative review of the general literature on stakeholder theory, corporate social responsibility, cross-sector partnerships (CSP) and strategic alliances, as well as of empirical studies on partnerships between schools and the third sector, offers insights on ethical conduct in these partnerships and their antecedents.FindingsBased on the general literature on CSP and the educational literature on third sector–school partnerships, the authors offer a conceptual model and propositions about ethical conduct in these partnerships and its antecedents.Originality/valueThe innovative conceptual model makes possible a re-evaluation of existing knowledge on third sector–school partnerships, and can support direct research of ethical aspects in these partnerships. In addition, the model provides conceptual language for administrators for managing practical ethical dilemmas in these partnerships.
Integration of expectation confirmation theory and self-determination theory in internet banking continuance intention
Authors: Rahi Samar , Abd. Ghani Mazuri 
Published: January 2019

Purpose
The expansion of information technology (IT) has become a great challenge in the business world today. Benefits from IT investment are only realized through sustained usage, rather than initial acceptance. Therefore, designing strategies continuously attracting user retention is the most critical and general question in IT global market. This paper aims to develop an integrated model that combines two well-known theories expectation confirmation theory (ECT) and self-determination theory (SDT) to determine customer’s continuance intention toward use internet banking.

Design/methodology/approach
A total number of 398 customers of commercial banks participated in this research. The research model was empirically tested using structural equation modeling.

Findings
The findings reveal that both ECT and SDT have significant influence in a customer’s continuance usage intention. The integrated model has good explanatory power (76.3%) to predict customer’s continuance intention toward use of internet banking. Additionally, importance performance matrix analysis indicates that intrinsic regulation and customer’s satisfaction are the most important factors to determine internet banking user’s continuance intention.

Practical implication
Internet banking users will be intrinsically motivated only for those activities that generate intrinsic interest for them, activities that have the charm of novelty, challenge or aesthetic significance. Thus, understanding banking customer intrinsic values should be a priority for managers and policymakers. Theoretically, integration of two well-known theories, ECT and SDT, provide basis for further refinement of technology continuance model in emerging e-payment domain.

Originality/value
This study is different from several traditional studies that had investigated initial acceptance of internet banking. In contrast, this study provides a comprehensive analysis of customer’s behavior in continuance intention context with technology (ECT) and motivational factors (SDT).
Factors and “illusions” influencing the choice of PFI-type public private partnerships
Authors: McQuaid Ronald 
Published: January 2019

PurposeThe purpose of this paper is to critically assess some of the micro- and macro-economic reasons for using public finance initiative types of public–private partnerships (PPPs) and how a lack of transparency may result in an “illusion” of making optimal, rational decisions related to them. A series of balances that decision makers need to make in order to choose whether or not to use PPPs are set out, as well as 15 potential “illusions” may affect such decisions.Design/methodology/approachThis paper synthesizes published evidence and develops a framework for analyzing PPPs.FindingsA wide range of factors influence the choice of PPPs, including: budget enlargement; efficiency and value for money; certainty of expenditure and delivery; flexibility; financing costs; risk sharing; procurement process and transaction costs; legacy and public assets; and the wider impacts on the local economy. However, reasons why PPPs can provide improved infrastructure and services may not be realised due to in-built incentives, behavioural biases and implementation shortcomings. Necessary support for PPPs includes strong, robust and transparent regulatory and governance systems, the dissemination of good practice to all partners, consideration of alternative funding models and high-quality advice and training.Research limitations/implicationsThe paper sets out a number of reasons for using PPPs, and also assesses potential drawbacks and identifies areas where greater research is required. A number of potential “illusions” are identified, whereby decisions may be affected by factors not explicitly or transparently considered, hence giving the decision an “illusion” being rational.Practical implicationsPPPs are significantly influenced by the socio-economic, legal, legislative and financial system they are embedded in. A clear process for approving projects and recognising all the costs and benefits of PPPs is needed, including developing criteria and instruments to measure each phase of a PPP and its overall value added to the economy and society over its lifetime. Full transparency, having suitable support and explicitly taking account of potential “illusions” affecting decisions, could lead to different decisions, including the decision not to progress the project or to use alternative funding and development methods.Social implicationsDecisions on PPPs should be based on a clear and transparent long-term basis which includes the perspectives of the full range of stakeholders to help improve the appropriate operation and social sustainability of a PPP.Originality/valueThe paper sets out some key arguments for and against the use of PPPs in different circumstances, including why non-optimal decisions may be made.
Fast estimation of prestack common reflection surface parameters
Authors: Waldeland Anders U. , Coimbra Tiago A. , Faccipieri Jorge H. , Solberg Anne H. Schistad , Gelius Leiv‐J. 
Published: January 2019

ABSTRACTWe present a method for fast estimation of finite offset common reflection surface parameters. Firstly, the derivatives with respect to offset are derived from the velocity guide. Secondly, we apply structure tensors to extract the derivatives with respect to midpoint from stacked common offset sections. Finally, the mixed derivative is estimated using a one‐parametric semblance search. The proposed method is compared to the global five‐parametric semblance search and the pragmatic sequential two‐parametric semblance search on one synthetic and one real data set. The experiments show that the proposed method is more robust against noise than the pragmatic search and have comparable robustness with the global search. The proposed method smoothes parameter estimates in a local window, and the window size is set to give the best trade‐off between detail and robustness. Since the proposed method is dependent on a velocity guide, the quality of the other parameter estimates may be influenced by any inaccuracies in the guide. The main advantage of the proposed method is the computational efficiency. When compared with a gridded implementation of the semblance search, the proposed method is 10 and 400 times faster than the pragmatic and global search. Alternative search strategies significantly reduce the computational cost of the global search. However, since more than 99% of the computational cost of the proposed method comes from the semblance search to estimate the mixed derivative, it is expected that such techniques also reduce the computational cost for the proposed method.
Patients’ autonomy as a negotiated order: an ethnographic perspective on the clinical management of childhood obesity
Authors: Lutz Andrea Giovanni 
Published: January 2019

AbstractThe principle of patients’ autonomy has assumed a central place in healthcare. Patients are encouraged to play an active role in the management of their health, especially when they are affected by chronic illnesses that require long‐term follow‐up. In this article, we analyse patients’ and professionals’ conceptions of patients’ autonomy in the context of childhood obesity management. Based on the results of an ethnographic study that we conducted within a paediatric hospital in French‐speaking Switzerland, we put into perspective the discourses that professionals, parents and children construct around their experiences of the therapy. Our study reveals that the conceptions that these three different actors have of patients’ autonomy converge on several points, but they also diverge on many others. While the rise of autonomy in healthcare has mostly been analysed as a form of empowerment of patients, our results show that this principle also introduces new forms of social control over patients’ lives, and it creates new tensions for patients who are unable to match with the normative expectations of professionals in terms of self‐management and self‐care.
Informalization of the State: Reflections from an Urban World of Translations
Authors: Boudreau Julie‐Anne 
Published: January 2019

AbstractThe project of globalizing informality requires the circulation of concepts and theories from the ‘South’ to the ‘North’. It also relies on intertextuality and exchanges across languages and sites of academic production. This essay is a reaction to the collection of papers presented in this forum. It argues for more academic conversations between languages and cities in order to contribute to a general state theory.
Juggling Legitimacies: Informal Places for Burials and Worship in Hong Kong
Authors: Fokdal Josefine 
Published: January 2019

AbstractThe Hong Kong government's neoliberal approach regarding land development and urbanization affects not only the housing market but also burial places, increasing inequality for both the living and the dead. The urgency of tackling the issue of places for burial is all the more pressing given current demographic changes and an existing backlog of public burial places in inner‐city locations. Against this backdrop, this paper focuses on the cultural practices around burial and worship among the inhabitants of Hong Kong, and on their struggle to maintain these practices. It illustrates various forms and means of legitimacy (e.g. pragmatic, normative and cognitive) being applied by all actors, and shows how the continuing practices around worship and burial lead to the production of informality. The main argument is that socially constructed legitimacy can be gained and lost by various actors in a dynamic negotiation process based on belief systems, rules and norms (following Suchman, 1995). Thus, it should be understood as a strategic mode both within and outside the state. This perspective of legitimacy provides a better understanding of how and by what means resources and power are being negotiated in order to draw lessons from informal dynamics.
The Myth of Formality in the Global North: Informality‐as‐Innovation in Dutch Governance
Authors: Jaffe Rivke , Koster Martijn 
Published: January 2019

AbstractWhy has urban informality in the global North received so little attention? We suggest that this neglect can be explained in part by the tendency of scholarship to reproduce the myth of Northern formality: the widely held belief that informality occurs only in corrupt and clientelist ‘developing countries’. This myth has allowed activities and connections that would generally be framed as clientelist or corrupt in the global South to be rebranded as policy innovation in Western Europe and North America. In this brief paper, we challenge the myth of Northern formality by focusing on two empirical cases of informality in Dutch governance that demonstrate how the state frames the toleration and deliberate use of informality as policy innovations. Specifically, we focus on strategic, uncodified and non‐transparent deviation from legal procedure in order to achieve compliance and/or effectiveness. Relying on ethnographic methods and secondary sources, we discuss firstly the governance of Amsterdam's red light district and secondly participatory infrastructure projects in the surrounding province of North Holland. The first case highlights the strategic non‐enforcement or non‐application of laws, while the second case points to the use of personalized relationships and non‐transparency in participatory governance.
The Disciplinary Role of Financial Statements: Evidence from Mergers and Acquisitions of Privately Held Targets
Authors: CHEN CIAO‐WEI 
Published: January 2019

ABSTRACTThis study examines whether requiring the disclosure of audited financial statements disciplines managers’ mergers and acquisitions (M&As) decisions. When an M&A transaction meets certain disclosure thresholds, the Securities and Exchange Commission (SEC) requires the public acquirer to disclose the target's audited financial statements after the merger is completed. Using hand‐collected data, I find that the disclosure of private targets’ financial statements is associated with better acquisition decisions. Furthermore, I find that this disciplining effect of disclosure is more pronounced when monitoring by outside capital providers is more difficult and costly, and when other disciplining mechanisms are weaker. Finally, these findings are robust to several alternative explanations, such as monitoring from blockholders and voluntary disclosures. In sum, the evidence suggests that the ex post mandatory disclosure of private targets’ accounting information disciplines managers’ acquisition decisions and improves acquisition efficiency.
Endoscopic features of sessile serrated adenoma/polyps under narrowband imaging: A retrospective study
Authors: Zhang Xin Tian , Zhang Qing Wei , Liu Fei , Lin Xiao Lu , Chen Jin Nan , Li Xiao Bo 
Published: January 2019

ObjectiveSessile serrated adenoma/polyps (SSA/P) are recognized as precancerous lesions in the colon and resemble hyperplastic polyps (HP). Definite endoscopic features under narrow band imaging (NBI) with or without magnification may help differentiate these two lesions. Our study aimed to identify specific endoscopic features of SSA/P by NBI.MethodsA total of 199 patients with histopathologically proven colorectal SSA/P or HP after a polypectomy were enrolled. Magnifying and non‐magnifying NBI pictures of 206 matching lesions were evaluated by one expert and two non‐expert endoscopists using various endoscopic characteristics retrospectively.ResultsMultivariate analysis indicated that a clouded surface (odds ratio [OR] 6.48, 95% confidence interval [CI] 2.72‐15.44, P = 0.000) and dilated and branching vessels (DBV) (OR 7.95, 95% CI 3.71‐17.02, P = 0.000) were significant endoscopic features for diagnosing SSA/P compared with HP. The combination of these two features could improve diagnostic specificity to 96%, and the area under the receiver operating characteristic curve was 0.749. However, it seemed that the presence of dark spots (OR 1.93, 95% CI 0.94‐4.00, P = 0.075) was not a definite feature in differentiating these two lesions. Neither a mucus cap nor CP‐II meshed capillary vessels showed statistical significance in differentiating SSA/P from HP (P = 0.590 and 0.293, respectively).ConclusionsA clouded surface and DBV were two indicators for diagnosing SSA/P. Combining these two factors together under NBI with or without magnification achieved better diagnostic performance than when they were used alone.
Does one size fit all? Evidence on XBRL adoption and 10‐K filing lag
Authors: Zhou Jie 
Published: January 2019

AbstractThis paper examines how XBRL adoption is associated with 10‐K filing timeliness. Using a sample of 10‐K filings from 2007 to 2016, we find that 10‐K filing lag decreases for Tier 1, Tier 2 and Tier 3 accelerated filers following the XBRL mandate. For Tier 3 smaller reporting companies, however, filing lag increases significantly in the post‐XBRL period. Results from a difference‐in‐differences specification as well as using an alternative measure of filing timeliness produce similar inferences. We then investigate factors associated with the delay. We find that 10‐K filing lag increases with XBRL filing complexity, whereas the deployment of a more experienced service provider can mitigate the lag. Overall, this study provides evidence that XBRL mandate improves preparer efficiency for most firms; however, our finding that the effect for smaller reporting companies goes in the opposite direction leads to the question whether XBRL can be viewed as a one‐size‐fits‐all solution to financial reporting.