bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing oral communication in Spanish lower-level courses: The case of voice recording and videoconferencing activities
Authors: Tecedor Marta , Campos-Dintrans Gonzalo 
Published: October 2018

AbstractThis study adds to the literature on computer-mediated communication (CMC) by examining the impact of online voice recording (VR) activities and peer-to-peer videoconferencing (VC) conversations on the development of beginning Spanish learners’ speaking performance. Specifically, this paper explores (1) whether VR and VC activities promote oral proficiency, and if so, whether those gains can be seen both in presentational and interpersonal modes of communication; and (2) whether VR and VC activities foster oral proficiency in similar ways to face-to-face (F2F) communication. A quasi-experimental, pre-/post-test design was used in the study. Three sections of a first semester Spanish course were assigned to one of the following conditions: F2F, VR, and VC. Complexity, accuracy, and fluency measures were used to analyze learners’ speaking performance in the two tasks. A mixed effects model analysis was used to investigate differences across time as well as among groups. Results show that both F2F communication and VR activities promote complexity and fluency in presentational tasks and fluency in interpersonal tasks, although F2F produces superior results regarding complexity in presentational tasks. VC activities promote complexity and fluency in presentational tasks and complexity, accuracy, and fluency in interpersonal tasks. Overall, this study shows that medium is not merely a delivery device but has important implications for learning outcomes. In this sense, these findings contribute to answering the wider question of how the use of technology in second language instruction plays a decisive role in current teaching practices.
Prehospital Airway Management Examined at Two Pediatric Emergency Centers
Authors: Tweed Jefferson , George Taylor , Greenwell Cynthia , Vinson Lori 
Published: October 2018

AbstractIntroductionRoutine advanced airway usage by Emergency Medical Services (EMS) has had conflicting reports of being the secure airway of choice in pediatric patients.Hypothesis/ProblemThe primary objective was to describe a pediatric cohort requiring airway management upon their arrival directly from the scene to two pediatric emergency departments (PEDs). A secondary objective included assessing for associations in EMS airway management and patient outcomes.MethodsRetrospective data from the health record were reviewed, including EMS reports, for all arrivals less than 18 years old to two PEDs who required airway support between May 2015 and July 2016. The EMS management was classified as basic (oxygen, continuous positive airway pressure [CPAP], or bag-valve-mask [BVM]) or advanced (supraglottic or endotracheal intubation [ETI]) based on EMS documentation. Outcomes included oxygenation as documented by receiving PED and hospital mortality.ResultsIn total, 104 patients with an average age 5.9 (SD=5.1) years and median EMS Glasgow Coma Scale (GCS) of nine (IQR 3-14) were enrolled. Basic management was utilized in 70% of patients (passive: n=49; CPAP: n=2; BVM: n=22). Advanced management was utilized in 30% of patients (supraglottic: n=4; ETI: n=27). Proper ETI placement was achieved in 48% of attempted patients, with 41% of patients undergoing multiple attempts. Inadequate oxygenation occurred in 18% of patients, including four percent of ETI attempts, nine percent of BVM patients, and 32% of passively managed patients. Adjusted for EMS GCS, medical patients undergoing advanced airway management experienced higher risk of mortality (risk-ratio [RR] 2.98; 95% CI, 1.18-7.56; P=.021).ConclusionWith exception to instances where ETI is clearly indicated, BVM management is effective in pediatric patients who required airway support, with ETI providing no definitive protective factors. Most of the patients who exhibited inadequate oxygenation upon arrival to the PED received only passive oxygenation by EMS.TweedJ,GeorgeT,GreenwellC,VinsonL.Prehospital airway management examined at two pediatric emergency centers.Prehosp Disaster Med.2018;33(5):532–538.
Epidemiological Evaluation of Dogs Rescued in the Fukushima Prefecture Following the Great East Japan Earthquakes of 2011
Authors: Tanaka Aki , Martinez-Lopez Beatriz , Kass Philip 
Published: October 2018

AbstractIntroductionDogs left behind in the restricted area by the Great East Japan Earthquakes of 2011 (Fukushima Prefecture, Japan) were initially rescued at a temporary first response shelter under chaotic conditions: poor housing and husbandry was maintained by unfamiliar/untrained staff, and lack of exercise was associated with deterioration of the mental and physical health of the impounded dogs. The objectives of this study were to report characteristics, disposition, and health status of dogs rescued in the Fukushima Prefecture, and to perform a retrospective epidemiological evaluation of factors associated with disposition and disease incidence at shelters.ProblemsThe problems addressed in this study were shelter-related health issues at the first response shelter and reasons for retained adoption at the secondary shelter that caused delayed closure of the shelter.MethodsA retrospective cohort study was performed with all dogs that were rescued from the restricted area in the Fukushima Prefecture. Kaplan-Meier time-to-event analysis was performed to estimate the median days to outcomes. A chi-square test of homogeneity was used to determine whether ownership status was associated with breed. Cox proportional hazards regression models were used to assess the association between time-to-adoption with ownership status, age, sex, and breed, the association between time to onset of diarrhea with age and breed, and between duration of diarrheic symptoms with the number of antibiotics and the number of medications.ResultsFive-hundred and twenty-nine dogs were admitted to the Ihno and Miharu shelters (Fukushima Prefecture), including 179 that had detailed medical records. Seventy-six percent of dogs were mixed breed. Twenty-six percent of dogs had verified ownership, and almost 16% of dogs were reclaimed by their owners. Sixty-six percent of dogs developed diarrhea, and 17 different antibiotics were used to treat it. Using three or more different antibiotics was associated with prolonged signs of diarrhea. Dogs with verified ownership took longer for adoption than those without verified ownership. Breed and sex were not significantly associated with time to adoption. Age was associated with prolonged time to adoption.ConclusionTo improve the welfare of dogs in disasters, responsible owner education, a well-organized registered volunteer training program for care of animals at shelters, proper disease management protocols, and enrichment strategies to prevent stress and disease in shelter setting are essential.TanakaA,Martinez-LopezB,KassP.Epidemiological evaluation of dogs rescued in the Fukushima Prefecture following the Great East Japan Earthquakes of 2011.Prehosp Disaster Med.2018;33(5):478–583.
Extractive multi-document summarization based on textual entailment and sentence compression via knapsack problem
Authors: NASERASADI ALI , KHOSRAVI HAMID , SADEGHI FARAMARZ 
Published: October 2018

AbstractBy increasing the amount of data in computer networks, searching and finding suitable information will be harder for users. One of the most widespread forms of information on such networks are textual documents. So exploring these documents to get information about their content is difficult and sometimes impossible. Multi-document text summarization systems are an aid to producing a summary with a fixed and predefined length, while covering the maximum content of the input documents. This paper presents a novel method for multi-document extractive summarization based on textual entailment relations and sentence compression via formulating the problem as a knapsack problem. In this approach, sentences of documents are ranked according to the extended Tf-Idf method, then entailment scores of selected sentences are computed. Through these scores, the final score of each sentence is calculated. Finally, by decreasing the lengths of sentences via sentence compression, the problem has been solved by greedy and dynamic Programming approaches to the knapsack problem. Experiments on standard summarization datasets and evaluating the results based on the Rouge system show that the suggested method, according to the best of our knowledge, has increased F-measure of query-based summarization systems by two per cent and F-measure of general summarization systems by five per cent.
Edwin Seligman, initiator of global progressive public finance
Authors: Woker Madeline 
Published: October 2018

AbstractThis article surveys the global acquaintances of Edwin Robert Anderson Seligman, a world-renowned authority on progressive public finance and professor of political economy at Columbia University between 1885 and 1933. Through his published writings, networks, and internationalist efforts, Seligman extended an emerging theory of progressive taxation to an international arena. This empowered his students, especially his Asian students, to build an analysis of the limitations of imperial political accountability and suggest bold financial reform. These links are uncovered for the first time and reveal Seligman’s place in the intellectual and political history of tax reform in American and European formal and informal empires. Consequently, the article also sheds new light on the history of what the legal historian Ajay Mehrotra has called the ‘early Columbia school of taxation and economic development’.
Global perspectives on Welsh Patagonia: the complexities of being both colonizer and colonized
Authors: Taylor Lucy 
Published: October 2018

AbstractThe nationalist Welsh colony in Patagonia, Y Wladfa, offers a peripheral vantage point from which to reconsider core assumptions about settler colonialism and the British World. Taking a fresh approach to settler colonial studies, this article both pays close attention to settler motives before embarkation and also analyses the case from a global perspective. It foregrounds the role of unequal power relations in Britain, the British World, and the global arena in shaping social relations at home and in the colony, as well as locating Y Wladfa within a constellation of Welsh sites and influences around the world. Analysis reveals the Welsh to occupy a complex position within such global hierarchies, and to be colonizing Patagonia from a colonized position. As such, this case at the margins of settler power reveals important ambiguities, tensions, and affinities that challenge assumptions in settler colonial theory, and open spaces that might enrich and deepen analysis of this fundamentally global relationship of power.
Secular trends 2013–2017 in overweight and visible dental decay in New Zealand preschool children: influence of ethnicity, deprivation and the Under-5-Energize nutrition and physical activity programme
Authors: Rush Elaine , Kirk Madeline , Parmar Priya , Young Leanne , Obolonkin Vladimir 
Published: October 2018

AbstractEarly-life intervention to reduce obesity and poor dental health through early-life nutrition will improve health outcomes in later life. This study examined the prevalence of overweight and obesity and visual dental decay in 4-year old children in New Zealand between 2013 and 2017, and the impact of a nutrition and physical activity intervention programme, Under-5-Energize (U5E), on prevalence of these conditions within ethnic groups and by deprivation. The data set included 277,963 4-year-old children, including 25,140 from the Waikato region children of whom 8067 attended one of the 121 early childhood centres (ECC) receiving the U5E programme from 2014. Purposively the U5E-ECC selected were attended by higher proportions of indigenous Māori children and children living in higher deprivation areas than non-U5E-ECC. From 2013 to 2017, the overall prevalence of obesity, as defined by World Health Organisation criteria, declined slightly but rates of dental decay did not change. In the Waikato region, the prevalence of obesity declined in non-Māori children from 2015 to 2017 and children attending U5E-ECC had lower rates of dental decay than non-U5E children. Binary logistic regression showed that between 2015 and 2017 visible dental decay was more likely in children who were Māori (3.06×3.17), living in high deprivation (1.54×1.66) and male (1.10) but less likely if attending an U5E-ECC (0.83×0.79). Early-life intervention had efficacy at reducing dental decay, and demonstrated that the origins of disparities in health such as ethnicity and deprivation need to be addressed further to break the intergenerational cycles of poor health.
Why I Stopped Believing in Customary International Law
Authors: JOYNER Daniel H. 
Published: October 2018

AbstractThere has been a recent proliferation of scholarship on the development, identification, and determination of customary international law [CIL]. Much of this has focused on explication of the theoretical and practical problems inherent in the modern use of CIL as a source of international law. However, there are influential voices who argue that CIL nevertheless continues to play a necessary role in the international legal system, and that many of the problems that have been identified are exaggerated. This paper maintains that the problems which have been identified in the processes of identification and determination of CIL are of such a serious and institutionalized nature as to produce a presumptive distrust of any statement about what is or is not CIL. It argues that the process of identifying and authoritatively determining CIL must evolve to more objectively evidence the positive assent of states to the making of customary rules.
The Flux and Emission of Dimethylsulfide From the Great Barrier Reef Region and Potential Influence on the Climate of NE Australia
Authors: Jones Graham , Curran Mark , Deschaseaux Elisabeth , Omori Yuko , Tanimoto Hiroshi , Swan Hilton , Eyre Bradley , Ivey John , McParland Erin , Gabric Albert , Cropp Roger 
Published: October 2018

AbstractConcentrations of dimethylsulfoniopropionate (DMSP), dimethylsulfide (DMS), and DMS flux are reported for the Great Barrier Reef (GBR), Great Barrier Reef Lagoon (GBRL), and Coral Sea. Generally higher concentrations of dimethylsulfoniopropionate and DMS occurred in coral reef waters, compared with GBRL concentrations. DMS flux from GBR coral reefs in summer ranged from nondetectable to 153 μmol m−2 d−1 (mean 6.4), while winter fluxes ranged from 0.02 to 15 μmol m−2 d−1 (mean 2.4). No significant seasonal difference in DMS flux occurred for the GBRL. High DMSw concentrations and DMS fluxes periodically occur at coral reefs during very low tides and elevated sea surface temperatures (SSTs). For the GBRL and GBR coral reefs there was a significant correlation between seawater DMSw concentrations and SST (p < 0.001), up to temperatures of 30 °C. During coral bleaching DMS flux from reefs almost completely shuts down when SSTs are >30 °C. The GBRL and associated coral reefs emit 439 and 32 MmolS per year, respectively. Cyclones on average produce 170 MmolS to the GBR atmosphere in summer. This amount can markedly increase during severe cyclones such as severe tropical Cyclone Debbie in March 2017. Overall, the annual DMS emission estimate from the GBRL and coral reefs in the GBR is 0.64 GmolS, with cyclones contributing 27% or greater of the annual emission estimate, depending on the cyclone intensity. Oxidation of atmospheric DMS can potentially affect solar radiation, SSTs, low‐level cloud cover, and rainfall causing cooling and warming of the climate in the GBR region as recent modeling predicts.
Reward and aversion processing in patients with post-traumatic stress disorder: functional neuroimaging with visual and thermal stimuli
Authors: Elman Igor , Upadhyay Jaymin , Langleben Daniel D. , Albanese Mark , Becerra Lino , Borsook David 
Published: November 2018

AbstractIn patients with post-traumatic stress disorder (PTSD), a decrease in the brain reward function was reported in behavioral- and in neuroimaging studies. While pathophysiological mechanisms underlying this response are unclear, there are several lines of evidence suggesting over-recruitment of the brain reward regions by aversive stimuli rendering them unavailable to respond to reward-related content. The purpose of this study was to juxtapose brain responses to functional neuroimaging probes that reliably produce rewarding and aversive experiences in PTSD subjects and in healthy controls. The stimuli used were pleasant, aversive and neutral images selected from the International Affective Picture System (IAPS) along with pain-inducing heat applied to the dorsum of the left hand; all were administered during 3 T functional magnetic resonance imaging. Analyses of IAPS responses for the pleasant images revealed significantly decreased subjective ratings and brain activations in PTSD subjects that included striatum and medial prefrontal-, parietal- and temporal cortices. For the aversive images, decreased activations were observed in the amygdala and in the thalamus. PTSD and healthy subjects provided similar subjective ratings of thermal sensory thresholds and each of the temperatures. When 46 °C (hot) and 42 °C (neutral) temperatures were contrasted, voxelwise between-group comparison revealed greater activations in the striatum, amygdala, hippocampus and medial prefrontal cortex in the PTSD subjects. These latter findings were for the most part mirrored by the 44 vs. 42 °C contrast. Our data suggest different brain alterations patterns in PTSD, namely relatively diminished corticolimbic response to pleasant and aversive psychosocial stimuli in the face of exaggerated response to heat-related pain. The present findings support the hypothesis that brain sensitization to pain in PTSD may interfere with the processing of psychosocial stimuli whether they are of rewarding or aversive valence.
TXNDC9 promotes hepatocellular carcinoma progression by positive regulation of MYC-mediated transcriptional network
Authors: Chen Dawei , Zou Jixue , Zhao Zhenguo , Tang Xiaodong , Deng Zhicheng , Jia Jingchao , Liu Shuanghai 
Published: October 2018

AbstractThe thioredoxin domain containing proteins are a group of proteins involved in redox regulation and have been recently reported to be associated with tumor progression. However, the role of thioredoxin proteins in hepatocellular carcinoma (HCC) remains largely unknown. Here in our study, we demonstrated that thioredoxin domain containing protein 9 (TXNDC9) was over-expressed in HCC and promoted HCC progression. We found that TXNDC9 expression was amplified in HCC tissues and associated with an advanced grade of HCC. And, we demonstrated that overexpression of TXNDC9 was correlated with poor prognosis of HCC. Furthermore, by using CRISPR-Cas9 mediated TXNDC9 knockout and RNA-seq analysis, we found that TXNDC9 accelerated HCC proliferation regulation. Moreover, we demonstrated that TXNDC9 directly interacted with MYC and knockout/knockdown of TXNDC9 decreased the protein levels of MYC and inhibited MYC-mediated transcriptional activation of its targets. Besides, we identified that TXNDC9 was trans-activated by FOXA1, JUND, and FOSL2 in HCC. Taken together, our study unveiled an oncogenic role of TXNDC9 in HCC and provided a mechanistic insight into the TXNDC9 mediated gene regulation network during HCC development.
A deadly dance: the choreography of host–pathogen interactions, as revealed by single-cell technologies
Authors: Chattopadhyay Pratip K. , Roederer Mario , Bolton Diane L. 
Published: October 2018

AbstractPathogens have numerous mechanisms by which they replicate within a host, who in turn responds by developing innate and adaptive immune countermeasures to limit disease. The advent of high-content single-cell technologies has facilitated a greater understanding of the properties of host cells harboring infection, the host’s pathogen-specific immune responses, and the mechanisms pathogens have evolved to escape host control. Here we review these advances and argue for greater inclusion of higher resolution single-cell technologies into approaches for defining immune evasion mechanisms by pathogens.
Unravelling the Role of O-glycans in Influenza A Virus Infection
Authors: Mayr Juliane , Lau Kam , Lai Jimmy C. C. , Gagarinov Ivan A. , Shi Yun , McAtamney Sarah , Chan Renee W. Y. , Nicholls John , von Itzstein Mark , Haselhorst Thomas 
Published: October 2018

AbstractThe initial stage of host cell infection by influenza A viruses (IAV) is mediated through interaction of the viral haemagglutinin (HA) with cell surface glycans. The binding requirement of IAVs for Galβ(1,4)Glc/ GlcNAc (lactose/lactosamine) glycans with a terminal α(2,6)-linked (human receptors) or α(2,3)-linked (avian receptors) N-acetylneuraminic residue commonly found on N-glycans, is well-established. However the role and significance of sialylated Galβ(1,3)GalNAc (core 1) epitopes that are typical O-glycoforms in influenza virus pathogenesis remains poorly detailed. Here we report a multidisciplinary study using NMR spectroscopy, virus neutralization assays and molecular modelling, into the potential for IAV to engage sialyl-Galβ(1,3)GalNAc O-glycoforms for cell attachment. H5 containing virus like particles (VLPs) derived from an H5N1 avian IAV strain show a significant involvement of the O-glycan-specific GalNAc residue, coordinated by a EQTKLY motif conserved in highly pathogenic avian influenza (HPAI) strains. Notably, human pandemic H1N1 influenza viruses shift the preference from ‘human-like’ α(2,6)-linkages in sialylated Galβ(1,4)Glc/GlcNAc fragments to ‘avian-like’ α(2,3)-linkages in sialylated Galβ(1,3)GalNAc without involvement of the GalNAc residue. Overall, our study suggests that sialylated Galβ(1,3)GalNAc as O-glycan core 1 glycoforms are involved in the influenza A virus life cycle and play a particularly crucial role during infection of HPAI strains.
Multi-parametric functional ultrasound imaging of cerebral hemodynamics in a cardiopulmonary resuscitation model
Authors: Demené Charlie , Maresca David , Kohlhauer Matthias , Lidouren Fanny , Micheau Philippe , Ghaleh Bijan , Pernot Mathieu , Tissier Renaud , Tanter Mickaël 
Published: October 2018

AbstractPatient mortality at one year reaches 90% after out-of-hospital cardiac arrest and resuscitation. Temperature management is one of the main strategies proposed to improve patient outcome after resuscitation and preclinical studies have shown neuroprotective effects when hypothermia is achieved rapidly, although the underlying mechanisms have not yet been elucidated. State-of-the-art brain imaging technologies can bring new insights into the early cerebral events taking place post cardiac arrest and resuscitation. In this paper, we characterized cerebral hemodynamics in a post-cardiac arrest rabbit model using functional ultrasound imaging. Ultrasound datasets were processed to map the dynamic changes in cerebral blood flow and cerebral vascular resistivity with a 10 second repetition rate while animals underwent cardiac arrest and a cardiopulmonary resuscitation. We report that a severe transient hyperemia takes place in the brain within the first twenty minutes post resuscitation, emphasizing the need for fast post-cardiac arrest care. Furthermore, we observed that this early hyperemic event is not spatially homogeneous and that maximal cerebral hyperemia happens in the hippocampus. Finally, we show that rapid cooling induced by total liquid ventilation reduces early cerebral hyperemia, which could explain the improved neurological outcome reported in preclinical studies.