bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposta de um Modelo para Comparação e Escolha de Frameworks para o Desenvolvimento de Software Baseado em Requisitos não Funcionais
Authors: Sandy José Mauro da Silva , Schiavoni Flávio Luiz 
Published: November 2018

A escolha dos frameworks utilizados ao longo do desenvolvimento de software causa um impacto direto na qualidade do produto desenvolvido, mas, muitas vezes, é realizada de forma subjetiva. Neste contexto, este artigo visa apresentar um modelo para realizar a escolha de frameworks de maneira racional por meio de um modelo iterativo, baseado nos requisitos não funcionais dos frameworks que serão avaliados. O modelo define três etapas que podem ser repetidas, caso exista alguma dúvida após o término de cada iteração. Na primeira etapa, a configuração do questionário é realizada com a definição das questões que serão utilizadas durante a avaliação e seus respectivos pesos. A próxima etapa consiste na aplicação do questionário configurado na primeira etapa, para posterior apuração dos resultados. Na terceira e última etapa, as respostas dadas são quantificadas para determinar qual o framework é mais indicado para o contexto avaliado. Ao terminar, caso ainda não seja possível definir qual o mais adequado, uma nova iteração pode ser realizada. O modelo proposto tem por objetivo decidir de forma racional qual framework deve ser adotado. Por fim, apresentamos um estudo de caso desse modelo na escolha do framework com bibliotecas gráficas para o projeto Mosaicode.
Review of scribal education in ancient Israel: The Old Hebrew epigraphic evidence by Christopher Rollston
Authors: Hewett Matthew R 
Published: November 2018

In this illustrative and thorough article, Christopher Rollston argues for the existence of, in R’s words, “a formal, standardized scribal education” in Ancient Israel (47). R bases his argument on a systematic analysis of the epigraphic evidence of Old Hebrew (i.e. Iron Age II Hebrew, ca. 1000-550 ce) and offers the following as his supporting arguments: (i) In terms of the ductus, the stance, and the relative spatial relationship of graphs, the Old Hebrew (OH) script: (a) displays synchronic consistency, (b) demonstrates discernable, diachronic development, and (c) differs markedly from those of nearby polities (Phoenicia, Arameans); (ii) In terms of orthography, the OH script exhibits synchronic (and arguably regional) consistency with distinctive features that were in opposition with the features of the Phoenician and Aramaic national scripts; and (iii) In terms of content, hieratic numerals (which derive from a complex number system originally borrowed from Egypt) were inscribed on many OH documents, suggesting that an administrative or governing body routinized their usage (and practical dissemination) throughout Iron Age Israel
Development and evaluation of a novel MR‐compatible pelvic end‐to‐end phantom
Authors: Cunningham Justine M. , Barberi Enzo A. , Miller John , Kim Joshua P. , Glide‐Hurst Carri K. 
Published: November 2018

AbstractMR‐only treatment planning and MR‐IGRT leverage MRI's powerful soft tissue contrast for high‐precision radiation therapy. However, anthropomorphic MR‐compatible phantoms are currently limited. This work describes the development and evaluation of a custom‐designed, modular, pelvic end‐to‐end (PETE) MR‐compatible phantom to benchmark MR‐only and MR‐IGRT workflows. For construction considerations, subject data were assessed for phantom/skeletal geometry and internal organ kinematics to simulate average male pelvis anatomy. Various materials for the bone, bladder, and rectum were evaluated for utility within the phantom. Once constructed, PETE underwent CT‐SIM, MR‐Linac, and MR‐SIM imaging to qualitatively assess organ visibility. Scans were acquired with various bladder and rectal volumes to assess component interactions, filling capabilities, and filling reproducibility via volume and centroid differences. PETE simulates average male pelvis anatomy and comprises an acrylic body oval (height/width = 23.0/38.1 cm) and a cast‐mold urethane skeleton, with silicone balloons simulating bladder and rectum, a silicone sponge prostate, and hydrophilic poly(vinyl alcohol) foam to simulate fat/tissue separation between organs. Access ports enable retrofitting the phantom with other inserts including point/film‐based dosimetry options. Acceptable contrast was achievable in CT‐SIM and MR‐Linac images. However, the bladder was challenging to distinguish from background in CT‐SIM. The desired contrast for T1‐weighted and T2‐weighted MR‐SIM (dark and bright bladders, respectively) was achieved. Rectum and bone exhibited no MR signal. Inputted volumes differed by <5 and <10 mL from delineated rectum (CT‐SIM) and bladder (MR‐SIM) volumes. Increasing bladder and rectal volumes induced organ displacements and shape variations. Reproduced volumes differed by <4.5 mL, with centroid displacements <1.4 mm. A point dose measurement with an MR‐compatible ion chamber in an MR‐Linac was within 1.5% of expected. A novel, modular phantom was developed with suitable materials and properties that accurately and reproducibly simulate status changes with multiple dosimetry options. Future work includes integrating more realistic organ models to further expand phantom options.
Extending the verifiability approach framework: The effect of initial questioning
Authors: Harvey Adam Charles , Vrij Aldert , Sarikas George , Leal Sharon , Jupe Louise , Nahari Galit 
Published: November 2018

SummaryThe verifiability approach (VA) is a lie‐detection tool that examines reported checkable details. Across two studies, we attempt to exploit liar's preferred strategy of repeating information by examining the effect of questioning adult interviewees before the VA. In Study 1, truth tellers (n = 34) and liars (n = 33) were randomly assigned to either an initial open or closed questioning condition. After initial questioning, participants were interviewed using the VA. In Study 2, truth tellers (n = 48) and liars (n = 48) were interviewed twice, with half of each veracity group randomly assigned to either the Information Protocol (an instruction describing the importance of reporting verifiable details) or control condition. Only truth tellers revised their initial statement to include verifiable detail. This pattern was most pronounced when initial questioning was open (Study 1) and when the information protocol was employed (Study 2). Thus, liar's preferred strategy of maintaining consistency between statements appears exploitable using the VA.
Graphene‐Sensitized Perovskite Oxide Monolayer Nanosheets for Efficient Photocatalytic Reaction
Authors: Li Di , Zhao Huaping , Li Longhua , Mao Baodong , Chen Min , Shen Hao , Shi Weidong , Jiang Deli , Lei Yong 
Published: November 2018

AbstractEfficient visible light harvesting and fast charge transfer are of high importance for solar‐energy conversion over semiconducting metal oxide photocatalysts. Here, a proof‐of‐concept strategy is developed to enable visible‐light photocatalytic activity of wide bandgap Ca2Nb3O10 monolayer nanosheet by incorporation of reduced graphene oxide (RGO) nanosheet as a photosensitizer. The Ca2Nb3O10 monolayer nanosheet/RGO 2D–2D nanohybrids exhibit largely elevated performance in photocatalytic H2 evolution with a H2 production rate of 820.76 µmol h−1 g−1 and tetracycline hydrochloride degradation reactions under the visible light irradiation. The combined experimental and theoretical results demonstrate that the electrons generated from the photoexcited RGO transfer to the Ca2Nb3O10 monolayer nanosheet and then participate in the photocatalytic reactions. The constructed RGO sensitized monolayer perovskite photocatalyst nanohybrids are demonstrated as an efficient photosensitizer for enhancing visible light harvesting of wide bandgap semiconductor in solar‐energy conversion, and elaborated in details of the charge transfer process of this type of nanohybrid photocatalyst.
Autonomous Ultrafast Self‐Healing Hydrogels by pH‐Responsive Functional Nanofiber Gelators as Cell Matrices
Authors: Gačanin Jasmina , Hedrich Jana , Sieste Stefanie , Glaßer Gunnar , Lieberwirth Ingo , Schilling Corinna , Fischer Stephan , Barth Holger , Knöll Bernd , Synatschke Christopher V. , Weil Tanja 
Published: November 2018

AbstractThe synthesis of hybrid hydrogels by pH‐controlled structural transition with exceptional rheological properties as cellular matrix is reported. “Depsi” peptide sequences are grafted onto a polypeptide backbone that undergo a pH‐induced intramolecular O–N–acyl migration at physiological conditions affording peptide nanofibers (PNFs) as supramolecular gelators. The polypeptide–PNF hydrogels are mechanically remarkably robust. They reveal exciting thixotropic behavior with immediate in situ recovery after exposure to various high strains over long periods and self‐repair of defects by instantaneous reassembly. High cytocompatibility, convenient functionalization by coassembly, and controlled enzymatic degradation but stability in 2D and 3D cell culture as demonstrated by the encapsulation of primary human umbilical vein endothelial cells and neuronal cells open many attractive opportunities for 3D tissue engineering and other biomedical applications.
General Resolution Enhancement Method in Atomic Force Microscopy Using Deep Learning
Authors: Liu Yue , Sun Qiaomei , Lu Wanheng , Wang Hongli , Sun Yao , Wang Zhongting , Lu Xin , Zeng Kaiyang 
Published: November 2018

AbstractHere, a resolution enhancement method is developed for post‐processing images from atomic force microscopy (AFM). This method is based on deep learning neural networks in the AFM topography measurements. In this study, a very deep convolution neural network is developed to derive a high‐resolution topography image from a low‐resolution topography image. The AFM measured images from various materials are tested in this study. The derived high‐resolution AFM images are comparable with the experimental measured high‐resolution images measured at the same locations. The results suggest that this method can be developed as a general post‐processing method for AFM image analysis.
Biomarkers for major depressive and bipolar disorders using metabolomics: A systematic review
Authors: MacDonald Kellie , Krishnan Ankur , Cervenka Emily , Hu Grace , Guadagno Elena , Trakadis Yannis 
Published: November 2018

AbstractMajor depressive disorder (MDD) and bipolar disorder (BD) lack robust biomarkers useful for screening purposes in a clinical setting. A systematic review of the literature was conducted on metabolomic studies of patients with MDD or BD through the use of analytical platforms such as in vivo brain imaging, mass spectrometry, and nuclear magnetic resonance. Our search identified a total of 7,590 articles, of which 266 articles remained for full‐text revision. Overall, 249 metabolites were found to be dysregulated with 122 of these metabolites being reported in two or more of the studies included. A list of biomarkers for MDD and BD established from metabolites found to be abnormal, along with the number of studies supporting each metabolite and a comparison of which biological fluids they were reported in, is provided. Metabolic pathways that may be important in the pathophysiology of MDD and BD were identified and predominantly center on glutamatergic metabolism, energy metabolism, and neurotransmission. Using online drug registries, we also illustrate how metabolomics can facilitate the discovery of novel candidate drug targets.
Visible‐Light‐Mediated Metal‐Free Difunctionalization of Alkenes with CO2 and Silanes or C(sp3)−H Alkanes
Authors: Hou Jing , Ee Aloysius , Cao Hui , Ong Han‐Wee , Xu Jin‐Hui , Wu Jie 
Published: November 2018

AbstractCatalytic alkene difunctionalization via Si−H and C−H activations represents an ideal atom‐ and step‐economic pathway for quick assembly of molecular complexity. We herein developed a visible‐light‐promoted metal‐free difunctionalization of alkenes using abundant CO2 and readily available Si−H and C(sp3)−H bonds as feedstocks. Through the merger of photoredox and hydrogen‐atom‐transfer catalysis, a variety of value‐added compounds, such as β‐silacarboxylic acids and acids bearing a γ‐heteroatom (e.g., N, O, S) could be directly accessed from simple alkenes in a redox‐neutral fashion.
Maximum Bony Gape in Primates
Authors: Fricano Ellen E. I. , Perry Jonathan M. G. 
Published: November 2018

ABSTRACTMaximum jaw gape has important functional implications for behavior and feeding habits in primates. It has been suggested that gape is correlated to canine height and ingested food size. Extending these correlations to the fossil record would provide insights about the diets and/or social behavior of extinct primates. However, this can be problematic due to uncertainty about size and location of musculature, and it depends on reliability and repeatability of maximum gape estimation using only skeletal elements. In this study, maximum bony gape (MBG) was estimated using reliable landmarks and repeatable methods. The cranium was fixed in position and then the mandible was rotated and translated to the point immediately prior to loss of condyle‐glenoid contact. Then it was photographed in a steady position using an adjustable wooden frame. This protocol allowed for photographs and linear measurements to be obtained for many museum specimens in a short time. The sample included 203 individuals, representing 42 species of primates. When scaled for body size, linear MBG correlates with maximum anesthetized gape (Hylander: Am J Phys Anthropol 150 (2013) 247–259), ingested food size (Perry and Hartstone‐Rose: Am J Phys Anthropol 142 (2010) 625–635), and canine length but not condylar height. Anat Rec, 302:215–225, 2019. © 2018 Wiley Periodicals, Inc.
Disruption of RHOA‐ROCK Signaling Results in Atrioventricular Block and Disturbed Development of the Putative Atrioventricular Node
Authors: Kelder Tim P. , Vicente‐Steijn Rebecca , Poelmann Robert E. , Schalij Martin J. , Deruiter Marco C. , Jongbloed Monique R. M. , Gittenberger‐de Groot Adriana C. 
Published: November 2018

ABSTRACTThe RHOA‐ROCK signaling pathway is involved in numerous developmental processes, including cell proliferation, differentiation and migration. RHOA is expressed in the atrioventricular node (AVN) and altered expression of RHOA results in atrioventricular (AV) conduction disorders in mice. The current study aims to detect functional AVN disorders after disturbing RHOA‐ROCK signaling in chicken embryos. RHOA‐ROCK signaling was inhibited chemically by using the Rho‐kinase inhibitor compound Y‐27632 in avian embryos (20 experimental and 29 control embryos). Morphological examination of control embryos show a myocardial sinus venosus to atrioventricular canal continuity, contributing to the transitional zone of the AVN. ROCK inhibited embryos revealed lateralization and diminished myocardial sinus venosus to atrioventricular canal continuity and at the severe end of the phenotype hypoplasia of the AVN region. Ex ovo micro‐electrode recordings showed an AV conduction delay in all treated embryos as well as cases with first, second (Wenkebach and Mobitz type) and third‐degree AV block which could be explained by the spectrum of severity of the morphological phenotype. Laser capture microdissection and subsequent qPCR of tissue collected from this region revealed disturbed expression of HCN1, ISL1, and SHOX2. We conclude that RHOA‐ROCK signaling is essential for normal morphological development of the myocardial continuity between the sinus venosus and AVN, contributing to the transitional zone, and possibly the compact AVN region. Disturbing the RHOA‐ROCK signaling pathway results in AV conduction disturbances including AV block. The RHOA‐ROCK inhibition model can be used to further study the pathophysiology and therapeutic strategies for AV block. Anat Rec, 302:83–92, 2019. © 2018 Wiley Periodicals, Inc.
Control Interventions Can Impact Alveolarization and the Transcriptome in Developing Mouse Lungs
Authors: Fehl Joshua , Pozarska Agnieszka , Nardiello Claudio , Rath Philipp , Surate Solaligue David E. , Vadász István , Mayer Konstantin , Herold Susanne , Seeger Werner , Morty Rory E. 
Published: November 2018

ABSTRACTThere is currently much interest in understanding the mechanisms of normal and aberrant lung alveolarization, particularly in the context of bronchopulmonary dysplasia, a common complication of preterm birth where alveolarization is impeded. To this end, the parenteral administration of pharmacological agents that modulate biochemical pathways, or facilitate modulation of gene expression in transgenic animals, has facilitated the discovery and validation of mechanisms that direct lung development. Such studies include control interventions, where the solvent vehicle, perhaps containing an inactive form of the agent applied, is administered; thereby providing a well‐controlled point of reference for the analysis of the partner experiment. In the present study, the impact of several widely used control interventions in developing C57Bl/6J mouse pups was examined for effects on lung structure and the lung transcriptome. Parenteral administration of scrambled microRNA inhibitors (called antagomiRs) that are used to control in vivo microRNA neutralization studies, impacted lung volume, septal thickness, and the transcriptome of developing mouse lungs; with some effects dependent upon nucleotide sequence. Repeated intraperitoneal isotonic saline injections altered lung volume, with limited impact on the transcriptome. Parenteral administration of the tamoxifen solvent Miglyol accelerated mouse pup growth, and changed the abundance of 73 mRNA transcripts in the lung. Tamoxifen applied in Miglyol—in the absence of Cre recombinase—decreased pup growth, lung volume, and lung alveolarization and changed the abundance of 298 mRNA transcripts in the lung. These data demonstrate that widely used control interventions can directly impact lung alveolarization and the lung transcriptome in studies on lung development. Anat Rec, 302:346–363, 2019. © 2018 Wiley Periodicals, Inc.
Learning Acetabular Fracture Classification using a Three‐Dimensional Interactive Software: A Randomized Controlled Trial
Authors: Wang Huixiang , Lyu Fei , Sugand Kapil , Wong Sheungting , Lin Yanping , Wang Qiugen 
Published: November 2018

Acetabular fractures are a real challenge for junior doctors as well as experienced orthopedic surgeons. Correct fracture classification is crucial for appreciating the fracture type, surgical planning, and predicting prognosis. Although three‐dimensional (3D) tutorial is believed to improve the understanding of the complex anatomy structure, there have been few applications and randomized controlled trials to confirm it in orthopedics. This study aims to develop a 3D interactive software system for teaching acetabular fracture classification and evaluate its efficacy. Participants were randomly but evenly allocated into either the experimental group (who learned the acetabular fracture classification using a 3D software) or the control group (who used a traditional two‐dimensional [2D] tutorial). Both groups were then tasked to classify 10 acetabular fractures and complete a five‐point Likert scale on their satisfaction of each learning modality. To calculate significance (P < 0.05), independent t‐test was used for normally distributed data whereas Mann‐Whitney U test for non‐normally distributed data. The experimental group significantly outperformed the control group (t (28) = 2.526, P = 0.017) with identifying correct acetabular fracture classification. Moreover, Likert scale score in the experimental group was also significantly higher than in the control group (Z = 2.477, P = 0.013). This 3D classification software has objectively and subjectively showed an advantage over the traditional 2D tutorial, resulting in an improved classification accuracy and higher Likert scale score. The 3D software has the potential to improve both clinical knowledge as well as identifying correct patient management in orthopedics.
Incurred sample reanalysis in drug discovery bioanalysis
Authors: Giri Poonam , Patel Nirmal , Joshi Vipul , Giri Shyamkumar , Srinivas Nuggehally R. 
Published: November 2018

AbstractBioanalysis plays a key role during the drug discovery process to generate the pharmacokinetic data to facilitate unbiased evaluation of leads, optimized leads and drug candidates. Such pharmacokinetic data are used to enable key decisions in the drug discovery process. The aim of the work is to put forward a new strategy of performing the incurred sample reanalysis for select small molecule novel chemical entities at different stages of drug discovery prior to candidate selection. Three discovery programs representing hits, leads and optimized lead candidates were selected for the incurred sample reanalysis (ISR) analysis. From each discovery program, two novel chemical entities were selected for the ISR analysis. The time points considered for ISR generally varied among the programs; however, samples coinciding with drug absorption, distribution and elimination were considered in the ISR assessment. With the exception of a single ISR value that gave a high deviation (about 63%), the observed ISR values supported the discovery bioanalytical assays. While the individual bioanalytical laboratory can draw an algorithm for selecting novel chemical entities and fixing the acceptance criteria for the ISR data, it is proposed that the percentage difference between ISR vs. original concentration for 67% of the repeat samples is contained within ±30% for discovery bioanalysis.
Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset
Authors: Nakagawa Nobuhiko , Kanda Mitsuro , Ito Seiji , Mochizuki Yoshinari , Teramoto Hitoshi , Ishigure Kiyoshi , Murai Toshifumi , Asada Takahiro , Ishiyama Akiharu , Matsushita Hidenobu , Tanaka Chie , Kobayashi Daisuke , Fujiwara Michitaka , Murotani Kenta , Kodera Yasuhiro 
Published: November 2018

AbstractBackgroundAdvanced gastric cancer frequently recurs even after radical resection followed by adjuvant chemotherapy. The aim of this study was to evaluate the relationship between pathological infiltrative pattern (INF) and initial recurrence patterns in patients with stage II/III gastric cancer using a large multicenter database.MethodsWe retrospectively analyzed 1098 eligible patients who underwent curative gastrectomy for stage II/III gastric cancer at nine institutions between 2010 and 2014. Patients were categorized into the INF‐a/b and INF‐c groups and adjusted using propensity score matching.ResultsAfter propensity score matching, 686 patients (343 for each) were classified in the INF‐a/b and INF‐c groups. There were no significant differences in overall and disease‐free survival between the two groups. In the INF‐a/b group, frequencies of recurrence at the peritoneum, lymph node, and liver were equivalent. In contrast, the peritoneum was the most frequent site and accounted for 60% of the total recurrences in the INF‐c group. The cumulative peritoneal recurrence rate was significantly higher in the INF‐c group than in the INF‐a/b group (hazard ratio 2.47). INF‐c was a significant risk factor for peritoneal recurrences in most subgroups including age, sex, macroscopic type, tumor differentiation, and disease stage, and whether the postoperative treatment was given. Multivariate analysis identified INF‐c as an independent risk factor for peritoneal recurrences. The cumulative liver recurrence rate was significantly higher in the INF‐a/b group than in the INF‐c group (hazard ratio 3.44).ConclusionsINF may represent an important predictor of recurrence patterns after curative resection of stage II/III gastric cancer.