bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Short-Term In-Season Weightlifting Training on the Muscle Strength, Peak Power, Sprint Performance, and Ball-Throwing Velocity of Male Handball Players
Authors: Hermassi Souhail , Schwesig René , Aloui Gaith , Shephard Roy J. , Chelly Mohamed Souhaiel 
Published: March 2019

Abstract
Hermassi, S, Schwesig, R, Aloui, G, Shephard, RJ, and Chelly, MS. Effects of short-term in-season weightlifting training on the muscle strength, peak power, sprint performance, and ball-throwing velocity of male handball players. J Strength Cond Res 33(12): 3309–3321, 2019—This study analyzed the effects of in-season weightlifting training, conducted biweekly for 12 weeks. Twenty-two male handball players were divided into experimental (age: 20.3 ± 0.5 years, height: 1.85 ± 0.04 m, and body mass: 86.3 ± 9.4 kg) and control (age: 20.1 ± 0.5 years, height: 1.81 ± 0.05 m, and body mass: 83.9 ± 10.3 kg) groups, and performance was assessed before and after the intervention. Peak power was determined by a cycle ergometer force-velocity test, a vertical squat jump, and a countermovement jump. Measures of 1 repetition maximal strength included bench press, back half-squats, snatch, and clean and jerk. Handball-throwing velocity was assessed by standing, running, and jump throws. The change of direction T-half test and sprint times over 5, 15, and 30 m were recorded by paired photocells. The intraclass correlation coefficient of all parameters exceeded 0.75. Significant training effects were seen for all sprint (3/3) and throwing (3/3) measures, but only 7/14 strength parameters and 3/10 jump parameters. The largest increases of performance were for snatch (η2 = 0.627; d = 2.85) and 15-m sprinting (η2 = 0.852; d = 2.73). Countermovement jump force showed a negative response (d = −0.62). Three other parameters (V0 power for the upper and lower limbs, countermovement jump power) showed only small effect sizes (d = 0.45, d = 0.31, and d = 0.23, respectively). We conclude that 12 weeks of biweekly in-season weight training improved the peak power, maximal strength, sprinting, and throwing in handball players, but that their jump performance did not increase with this kind of intervention.
Analysis of Physiological and Kinematic Demands of Wheelchair Basketball Games—A Review
Authors: Seron Bruna Barboza , Oliveira de Carvalho Emanuel Messias , Greguol Márcia 
Published: March 2019

AbstractSeron, BB, Oliveira de Carvalho, EM, and Greguol, M. Analysis of physiological and kinematic demands of wheelchair basketball games—A review.J Strength Cond Res33(5): 1453–1462, 2019—In wheelchair basketball (WB), knowledge of the specificities of the game is essential for efficient planning of training strategies for high performance. This study aimed to review the literature concerning studies that have investigated physiological and kinematic measures during WB games. The literature search took place in 4 electronic databases: Scopus, MEDLINE–PubMed, SPORTDiscus, and CINAHL. The inclusion criteria for this review were as follows: (a) articles that evaluated the behavior of physiological and kinematic variables during WB games; (b) athletes aged at least 18 years; and (c) participants with a minimum of 1 year in the modality practice. The selected studies (n= 16) were divided into 2 groups: physiological analysis (n= 11) and kinematic analysis (n= 5). In analyzing the studies, it was observed that the WB game is very demanding in relation to cardiovascular requirements (∼65% of the time is spent in zones of high heart rate [HR] intensity and 70% of Vo2peak). Edwards and Stagno methods seem to be adequate for the control of internal loads imposed on WB players, and moderate correlations were found between rating of perceived exertion measures and HR-based methods. Considering the methodological limitations, kinematic analysis in WB games is rather inconsistent (distance traveled between 2.6 and 5 km; average speed between 1.8 and 2.0 m·s−1; maximum speed = 4 m·s−1). Despite the gaps observed in this context, the execution of rotational movements seems to have great relevance for WB. We can conclude that different methods have been adequate for the internal load control in WB games. However, the results of the external demands are not enough to determine a profile nor to serve as parameters for the training prescription for athletes of the modality.
Selection of Heat Transfer Fluids for Solar Thermal Applications Using Multi-Criteria Decision-Making Tools
Authors: Kumar P. Ganesh , Yuvaraj N. , Kumaresan V. , Velraj R. 
Published: March 2019

Abstract
This article describes how optimization studies were carried out on a selection of optimal heat transfer fluids (HTFs) for solar applications with multiresponse characteristics based on the multi-criteria decision-making methodology (MCDM) using the Technique for Order Preference by Similarity Ideal Solution approach and grey relational analysis among 16 alternatives. The processing parameters’ thermophysical properties and the environmental, safety, and economic conditions are optimized with multiresponse characteristics, including the viscosity, thermal conductivity, specific heat capacity, density of fluid, thermal diffusivity, ozone depletion potential, global warming potential, flammability, toxicity, and cost of the fluid. In the proposed technique, the grade ratings and weights allocated by decision-makers are averaged and normalized into a comparable scale. By comparing both these techniques, deionized water is selected as the perfect HTF to operate the solar thermal applications. Hence, both of the techniques are suitable to establish the best possible solution for the set of input parameters depending upon the required performance characteristics. This article highlights a novel vision into MCDM methods to evaluate the best HTF for the decision-makers such as solar manufactures and research and development engineers to meet the low-cost, quick, appropriate, and environmentally friendly fluid selection.
Fatigue Performance Evaluation for an Orthotropic Steel Bridge Deck Based on Field Hotspot Stress Measurements
Authors: Chen Bin , Chen Zengshun , Xie Xu , Ye Xiaowei 
Published: March 2019

Abstract
This study has introduced a method for fatigue performance evaluation of steel orthotropic bridge decks based on filed measurements for hotspot stress. The long-term stress of the orthotropic bridge deck of Jinchang Road Canal Bridge in Hangzhou, China, was observed by sensors. The fatigue damage and fatigue reliability of the bridge deck were analyzed and evaluated according to the stress. The results show that: (a) the fatigue life of the bridge deck is larger than the design value, indicating that the design of the orthotropic bridge deck is reasonable; (b) the fatigue loads acting at three hotspots can be described by normal distribution; and (c) for the current traffic volume, the fatigue reliability index of the three hotspots is greater than two in the design period. The fatigue reliability index of the three hotspots decreases significantly with the increase of traffic flow, at which time the fatigue damage becomes considerable.
Phase Locking of Auditory-Nerve Fibers Reveals Stereotyped Distortions and an Exponential Transfer Function with a Level-Dependent Slope
Authors: Peterson Adam J. , Heil Peter 
Published: March 2019

Phase locking of auditory-nerve-fiber (ANF) responses to the fine structure of acoustic stimuli is a hallmark of the auditory system's temporal precision and is important for many aspects of hearing. Period histograms from phase-locked ANF responses to low-frequency tones exhibit spike-rate and temporal asymmetries, but otherwise retain an approximately sinusoidal shape as stimulus level increases, even beyond the level at which the mean spike rate saturates. This is intriguing because apical cochlear mechanical vibrations show little compression, and mechanoelectrical transduction in the receptor cells is thought to obey a static sigmoidal nonlinearity, which might be expected to produce peak clipping at moderate and high stimulus levels. Here we analyze phase-locked responses of ANFs from cats of both sexes. We show that the lack of peak clipping is due neither to ANF refractoriness nor to spike-rate adaptation on time scales longer than the stimulus period. We demonstrate that the relationship between instantaneous pressure and instantaneous rate is well described by an exponential function whose slope decreases with increasing stimulus level. Relatively stereotyped harmonic distortions in the input to the exponential can account for the temporal asymmetry of the period histograms, including peak splitting. We show that the model accounts for published membrane-potential waveforms when assuming a power-of-three, but not a power-of-one, relationship to exocytosis. Finally, we demonstrate the relationship between the exponential transfer functions and the sigmoidal pseudotransducer functions obtained in the literature by plotting the maxima and minima of the voltage responses against the maxima and minima of the stimuli.SIGNIFICANCE STATEMENTPhase locking of auditory-nerve-fiber responses to the temporal fine structure of acoustic stimuli is important for many aspects of hearing, but the mechanisms underlying phase locking are not fully understood. Intriguingly, period histograms retain an approximately sinusoidal shape across sound levels, even when the mean rate has saturated. We find that neither refractoriness nor spike-rate adaptation is responsible for this behavior. Instead, the peripheral auditory system operates as though it contains an exponential transfer function whose slope changes with stimulus level. The underlying mechanism is distinct from the comparatively weak cochlear mechanical compression in the cochlear apex, and likely resides in the receptor cells.
Neural Representations of Faces Are Tuned to Eye Movements
Authors: Stacchi Lisa , Ramon Meike , Lao Junpeng , Caldara Roberto 
Published: March 2019

Eye movements provide a functional signature of how human vision is achieved. Many recent studies have consistently reported robust idiosyncratic visual sampling strategies during face recognition. Whether these interindividual differences are mirrored by idiosyncratic neural responses remains unknown. To this aim, we first tracked eye movements of male and female observers during face recognition. Additionally, for every observer we obtained an objective index of neural face discrimination through EEG that was recorded while they fixated different facial information. We found that foveation of facial features fixated longer during face recognition elicited stronger neural face discrimination responses across all observers. This relationship occurred independently of interindividual differences in preferential facial information sampling (e.g., eye vs mouth lookers), and started as early as the first fixation. Our data show that eye movements play a functional role during face processing by providing the neural system with the information that is diagnostic to a specific observer. The effective processing of identity involves idiosyncratic, rather than universal face representations.SIGNIFICANCE STATEMENTWhen engaging in face recognition, observers deploy idiosyncratic fixation patterns to sample facial information. Whether these individual differences concur with idiosyncratic face-sensitive neural responses remains unclear. To address this issue, we recorded observers' fixation patterns, as well as their neural face discrimination responses elicited during fixation of 10 different locations on the face, corresponding to different types of facial information. Our data reveal a clear interplay between individuals' face-sensitive neural responses and their idiosyncratic eye-movement patterns during identity processing, which emerges as early as the first fixation. Collectively, our findings favor the existence of idiosyncratic, rather than universal face representations.
A Critical Role for Human Ventromedial Frontal Lobe in Value Comparison of Complex Objects Based on Attribute Configuration
Authors: Pelletier Gabriel , Fellows Lesley K. 
Published: March 2019

In making decisions, we often choose from among options with multiple value-relevant attributes. Neuroeconomic models propose that the value associated with each attribute is integrated in a global value for each option. However, some evidence from patients with ventromedial frontal lobe (VMF) damage argues against a very general role for this region in value integration, suggesting instead that it contributes critically to a specific value inference or comparison process. Here, we tested value-based decision-making involving artificial multiattribute objects in humans with focal damage to the VMF (N= 12) compared with a healthy group matched for age and education (N= 24) and with a group with frontal lobe damage sparing the VMF (N= 12). In a “configural” condition, overall object value was predicted by the conjunction of two attributes, while in an “elemental” condition, object value could be assessed by combining the independent values of individual attributes. Patients with VMF damage were impaired in making choices when value was uniquely predicted by the configuration of attributes, but intact when choosing based on elemental attribute values. This is evidence that the VMF is critical for inferring the value of whole objects in a multiattribute choice. These findings have implications for models of value-based choice and add to emerging views of how this region may interact with medial temporal lobe systems involved in configural object processing and relational memory.SIGNIFICANCE STATEMENTNeuroeconomic models propose that the ventromedial frontal lobe (VMF) supports multiattribute decisions by integrating the values of attributes. However, researchers have been uncertain about the underlying mechanisms for this process. Patients with VMF damage made multiattribute choices under two conditions: in one, attribute values could be summed to guide choice; in the other, value was predicted by the conjunction of attributes. VMF damage impaired only the latter. This argues that the VMF is critical for inferring value from configural information to guide multiattribute object choice. This region may be key for judging the emergent “value of the forest,” rather than for integrating the individual “value of each tree.”
Homer1a Is Required for Establishment of Contralateral Bias and Maintenance of Ocular Dominance in Mouse Visual Cortex
Authors: Chokshi Varun , Druciak Brian , Worley Paul F. , Lee Hey-Kyoung 
Published: March 2019

It is well established across many species that neurons in the primary visual cortex (V1) display preference for visual input from one eye or the other, which is termed ocular dominance (OD). In rodents, V1 neurons exhibit a strong bias toward the contralateral eye. Molecular mechanisms of how OD is established and later maintained by plastic changes are largely unknown. Here we report a novel role of an activity-dependent immediate early gene Homer1a (H1a) in these processes. Using both sexes of H1a knock-out (KO) mice, we found that there is basal reduction in the OD index of V1 neurons measured using intrinsic signal imaging. This was because of a reduction in the strength of inputs from the contralateral eye, which is normally dominant in mice. The abnormal basal OD index was not dependent on visual experience and is driven by postnatal expression of H1a. Despite this, H1a KOs still exhibited normal shifts in OD index following a short-term (2–3 d) monocular deprivation (MD) of the contralateral eye with lid suture. However, unlike wild-type counterparts, H1a KOs continued to shift OD index with a longer duration (5–6 d) of MD. The same phenotype was recapitulated in a mouse model that has reduced Homer1 binding to metabotropic glutamate receptor 5 (mGluR5). Our results suggest a novel role of H1a and its interaction with mGluR5 in strengthening contralateral eye inputs during postnatal development to establish normal contralateral bias in mouse V1 without much impact on OD shift with brief MD.SIGNIFICANCE STATEMENTVisual cortical neurons display varying degree of responsiveness to visual stimuli through each eye, which determines their ocular dominance (OD). Molecular mechanisms responsible for establishing normal OD are largely unknown. Development of OD has been shown to be largely independent of visual experience, but guided by molecular cues and spontaneous activity. We found that activity-dependent immediate early gene H1a is critical for establishing normal OD in V1 of mice, which show contralateral eye dominance. Despite the weaker contralateral bias, H1aKOs undergo largely normal OD plasticity. The basic phenotype of H1aKO was recapitulated by mGluR5 mutation that severely reduces H1a interaction. Our results suggest a novel role of mGluR5-H1a interaction in strengthening contralateral eye inputs to V1 during postnatal development.
NETest liquid biopsy is diagnostic of small intestine and pancreatic neuroendocrine tumors and correlates with imaging
Authors: Malczewska Anna , Witkowska Magdalena , Makulik Karolina , Bocian Agnes , Walter Agata , Pilch-Kowalczyk Joanna , Zajęcki Wojciech , Bodei Lisa , Oberg Kjell , Kos-Kudła Beata 
Published: March 2019

IntroductionCurrent monoanalyte biomarkers are ineffective in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). NETest, a novel multianalyte signature, provides molecular information relevant to disease biology.Aim(s)Independently validate NETest to diagnose GEP-NETs and identify progression in a tertiary referral center.Materials and methodsCohorts are 67 pancreatic NETs (PNETs), 44 small intestine NETs (SINETs) and 63 controls. Well-differentiated (WD) PNETs,n = 62, SINETs, all (n = 44). Disease extent assessment at blood draw: anatomical (n = 110) CT (n = 106), MRI (n = 7) and/or functional68Ga-SSA-PET/CT (n = 69) or18F-FDG-PET/CT (n = 8). Image-positive disease (IPD) was defined as either CT/MRI or68Ga-SSA-PET/CT/18F-FDG-PET/CT-positive. Both CT/MRI and68Ga-SSA-PET/CT negative diagnosis in WD-NETs was considered image-negative disease (IND). NETest (normal: 20): PCR (spotted plates). Data: mean ± SD.ResultsDiagnosisNETest was significantly increased in NETs (n = 111; 26 ± 21) vs controls (8 ± 4,p < 0.0001). Seventy-five (42 PNET, 33 SINET) were image positive. Eleven (8 PNET, 3 SINET; all WD) were IND. In IPD, NETest was significantly higher (36 ± 22) vs IND (8 ± 7,P < 0.0001). NETest accuracy, sensitivity and specificity are 97, 99 and 95%, respectivelyConcordance with imagingNETest was 92% (101/110) concordant with anatomical imaging, 94% (65/69) with68Ga-SSA-PET/CT and 96% (65/68) dual modality (CT/MRI and68Ga-SSA-PET/CT). In 70 CT/MRI positive, NETest was elevated in all (37 ± 22). In 40 CT/MRI negative, NETest was normal (11 ± 10) in 31. In 5668Ga-SSA-PET/CT positive, NETest was elevated (36 ± 22) in 55. In 1368Ga-SSA-PET/CT negative, NETest was normal (9 ± 8) in ten.Disease statusNETest was significantly higher in progressive (61 ± 26;n = 11) vs stable disease (29 ± 14; n = 64;P < 0.0001) (RECIST 1.1).ConclusionNETest is an effective diagnostic for PNETs and SINETs. Elevated NETest is as effective as imaging in diagnosis and accurately identifies progression.
Split-QF System for Fine-Tuned Transgene Expression in Drosophila
Authors: Riabinina Olena , Vernon Samuel W , Dickson Barry J , Baines Richard A 
Published: March 2019

Abstract
The Q-system is a binary expression system that works well across species. Here, we report the development and demonstrate the applications of a split-QF system that drives strong expression in Drosophila, is repressible by QS, and is inducible by a small nontoxic molecule (quinic acid). The split-QF system is fully compatible with existing split-GAL4 and split-LexA lines, thus greatly expanding the range of possible advanced intersectional experiments and anatomical, physiological, and behavioral assays in Drosophila, and in other organisms.
Electrochemical single-step obtention and characterization of a biomimetic TiO2-HA NTs covered by chitosan
Authors: Galvão Rhauane Almeida , Santa-Cruz Larissa Agostinho de , Barreto Paloma Bantim , Horta Marla Karolyne dos Santos , Andrade Antonio Marcos Helgueira de , Moura Francisco José , Aguilar Marilza Sampaio , Peripolli Suzana Bottega , Campos José Brant de , Arruda Isabel Renata de Souza , Machado Giovanna 
Published: March 2019

Abstract
Clinical Implications of Circulating Tumor DNA Tumor Mutational Burden (ctDNA TMB) in Non-Small Cell Lung Cancer
Authors: Chae Young Kwang , Davis Andrew A. , Agte Sarita , Pan Alan , Simon Nicholas I. , Iams Wade T. , Cruz Marcelo R. , Tamragouri Keerthi , Rhee Kyunghoon , Mohindra Nisha , Villaflor Victoria , Park Wungki , Lopes Gilberto , Giles Francis J. 
Published: March 2019

Abstract

Background
Tissue tumor mutational burden (TMB) has emerged as a potential biomarker predicting response to anti-programmed cell death-1 protein receptor (PD-1)/programmed cell death-1 protein ligand (PD-L1) therapy, but few studies have explored using circulating tumor DNA (ctDNA) TMB in non-small cell lung cancer (NSCLC).

Materials and Methods
A total of 136 patients with NSCLC with ctDNA testing were retrospectively evaluated from a single institution, along with a validation cohort from a second institution. ctDNA TMB was derived using the number of detected mutations over the DNA sequencing length.

Results
Higher ctDNA TMB was significantly correlated with smoking history (p &lt; .05, chi-squared test). Among patients treated with immune checkpoint inhibitors (n = 20), higher ctDNA TMB was significantly correlated with shorter progressive free survival (PFS) and overall survival (OS; 45 vs. 355 days; hazard ratio [HR], 5.6; 95% confidence interval [CI], 1.3–24.6; p &lt; .01, and OS 106 days vs. not reached; HR, 6.0; 95% CI, 1.3–27.1; p &lt; .01, respectively). In a small independent validation cohort (n = 12), there was a nonsignificant numerical difference for higher ctDNA TMB predicting shorter OS but not PFS. ctDNA TMB was not correlated with RECIST tumor burden estimation in the subset of patients treated with immune checkpoint blockade.

Conclusion
The findings indicate that higher ctDNA TMB, at the current commercial sequencing length, reflects worse clinical outcomes.
Онлайн-программа сравнительного тезаурусного анализа русских переводов произведений У. Шекспира: итоги и перспективы развития проекта
Authors: Гайдин Борис Николаевич 
Published: March 2019

<p>В статье представлены итоги двухлетней работы над проектом «Разработка и внедрение в открытом доступе онлайн-программы сравнительного тезаурусного анализа русских переводов произведений У. Шекспи­ра» (<a href="http://www.shakespearecorpus.ru" target="_self">www.shakespearecorpus.ru</a>), поддержанным грантом РФФИ (№ 17-04-12038в). На примере корпуса переводов пьесы «Троил и Крессида» У. Шекспира, выполненных Н. Х. Кетчером, А. Л. Соколовским, П. А. Каншиным, А. М. Федоровым, Л. С. Некорой, Т. Г. Гнедич и А. В. Флорей, автор демонстрирует возможности платформы и предпринимает попытку аналитического осмысления полученных данных.</p>