bluuebunny/crossref_metadata_2025_split huggingface dataset:
Muscle Synergies Obtained from Comprehensive Mapping of the Cortical Forelimb Representation Using Stimulus Triggered Averaging of EMG Activity
Authors: Amundsen Huffmaster Sommer L. , Van Acker Gustaf M. , Luchies Carl W. , Cheney Paul D. 
Published: August 2018

Neuromuscular control of voluntary movement may be simplified using muscle synergies similar to those found using non-negative matrix factorization. We recently identified synergies in electromyography (EMG) recordings associated with both voluntary movement and movement evoked by high-frequency long-duration intracortical microstimulation applied to the forelimb representation of the primary motor cortex (M1). The goal of this study was to use stimulus-triggered averaging (StTA) of EMG activity to investigate the synergy profiles and weighting coefficients associated with poststimulus facilitation, as synergies may be hard-wired into elemental cortical output modules and revealed by StTA. We applied StTA at low (LOW, ∼15 μA) and high intensities (HIGH, ∼110 μA) to 247 cortical locations of the M1 forelimb region in two male rhesus macaques while recording the EMG of 24 forelimb muscles. Our results show that 10–11 synergies accounted for 90% of the variation in poststimulus EMG facilitation peaks from the LOW-intensity StTA dataset while only 4–5 synergies were needed for the HIGH-intensity dataset. Synergies were similar across monkeys and current intensities. Most synergy profiles strongly activated only one or two muscles; all joints were represented and most, but not all, joint directions of motion were represented. Cortical maps of the synergy weighting coefficients suggest only a weak organization. StTA of M1 resulted in highly diverse muscle activations, suggestive of the limiting condition of requiring a synergy for each muscle to account for the patterns observed.SIGNIFICANCE STATEMENTCoordination of muscle activity and the neural origin of potential muscle synergies remains a fundamental question of neuroscience. We previously demonstrated that high-frequency long-duration intracortical microstimulation-evoked synergies were unrelated to voluntary movement synergies and were not clearly organized in the cortex. Here we present stimulus-triggered averaging facilitation-related muscle synergies, suggesting that when fundamental cortical output modules are activated, synergies approach the limit of single-muscle control. Thus, we conclude that if the CNS controls movement via linear synergies, those synergies are unlikely to be called from M1. This information is critical for understanding neural control of movement and the development of brain–machine interfaces.
Arquitetura da Informação para ambientes informacionais digitais
Authors: Carvalho Angela Maria Grossi de , França Maira Nani 
Published: August 2018

ResumoResenha do livro Information Architectutre: for the web and beyond de autoria de Louis Rosenfeld, Peter Morville e Jorge Arango.Palavras-chave: Arquitetura da informação. Ambientes informacionais digitais. Design digital. AbstractReview of the book Information Architectutre: for the web and beyond by Louis Rosenfeld, Peter Morville e Jorge Arango.Keywords: Information Architecture. Digital information environments. Digital design. ResumenReseña del libro Information Architectutre: for the web and beyond de la autoría de Louis Rosenfeld, Peter Morville y Jorge Arango.Palabras clave: Arquitectura de la Información. Ambientes informacionales digitales. Diseño digital.
CORONARY ARTERY PATHOLOGY IN RIGHT VENTRICULAR MYOCARDIAL INFARCTION
Authors: Ayrapetyan G. G. , Adamyan K. G. 
Published: August 2018

Aim. To study anatomical and functional features of coronary blood flow in myocardial infarction (MI) of left ventricular (LV) inferior wall with the involvement of right ventriculum (RV).Material and methods. The study included 120 patients who suffered MI of LV inferior wall with (Group 2 – LVMI; n=58) or without (Group 1 – RVMI; n=62) RV involvement.Results. One coronary artery (CA) was affected in 65,0% of the participants. Right CA (RCA) pathology was registered in 97,4% (n=76), while circumflex CA (CxCA) pathology was observed only in 2,6% (n=2). Involvement of two and three or more CA was observed in 26,7% and 8,3% of the patients, respectively. Single CA pathology was at least 1,3 times more common in the RVMI group (p<0,05), while three or more CA were affected at least 8 times more often in the LVMI group (p<0,05). The right dominant, co-dominant, and left dominant types of coronary flow were registered in 76,7%, 15,0%, and 8,3% of the patients, respectively, all of whom were from the LVMI group. In 85% and 15% of the cases, the infarct-related artery (IRA) was RCA and CxCA, respectively. Among LVMI patients, RCA was the IRA almost three times more often than CxCA; among RVMI patients, this difference was 18-fold (p<0,001 for both comparisons). All LVMI patients (n=47) had distal occlusion of RCA, while all RVMI patients (n=55) had its proximal occlusion.Conclusion. Over two-thirds of the cases оf ST elevation MI of LV inferior wall with RV involvement occur in patients with the right dominant type of coronary blood flow. RVMI typically occurs in patients with right dominant type of coronary blood flow and PCA pathology. MI of LV inferior wall with RV involvement is characterised by proximal RCA occlusion.
CENTRALISED SURVEY ON THE UNDERTREATMENT OF THE HYPERCHOLESTEROLEMIA IN RUSSIA (CEPHEUS)
Authors: Boytsov S. A. , Khomitskaya Yu. V. 
Published: August 2018

Aim.To assess the percentage of the patients who receive lipid-lowering drug therapy and achieve target levels of low-density lipoprotein cholesterol (LDL–CH), in accordance with the recommendations by the Russian Cardiology Society (RCS) and the 4th Joint European Task Force (4JETF).Material and methods.The CEPHEUS study is a multi-centre, cross-sectional observational study with the participation of Russian patients. The study participants received lipid-lowering therapy for at least 3 months (no dose modification for ≥6 weeks). The start-date and end-date of the study were Oct 22nd 2010 and Mar 22nd 2011, respectively. The cross-sectional data were collected during a single visit to the clinic.Results.The study included 1000 Russian patients. Overall, target LDL–CH levels were achieved in 34,5% (RCS criteria) and 48,2% (4JEFT criteria) of the patients who received lipid-lowering therapy in the routine clinical practice. The patients who were treated for secondary prevention of cardiovascular events (CVE) achieved target levels of LDL–CH more often than the patients treated for primary prevention: 38,2% vs. 27,0%, respectively, by the RCS criteria (odds ratio (OR) 1,67; 95% confidence interval (CI) 1,22–2,28; p=0,001) and 54,5% vs. 35,4%, respectively, by the 4JEFT criteria (OR 2,19; 95% CI 1,63–2,95; p<0,001).Conclusion.Target levels of LDL–CH are achieved by <50% of the Russian patients who receive lipid-lowering treatment. This percentage is even lower in patients receiving lipid-lowering treatment for primary CVE prevention.
PROGRESSING CHRONIC KIDNEY DISEASE AND THE 12-MONTH DYNAMICS OF CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS
Authors: Markova A. V. , Schwartz Yu. G. 
Published: August 2018

Aim. To assess the association between the 12-month dynamics of cardiovascular risk factors (CVD RFs), progressing chronic kidney disease (CKD), and individual baseline clinical and laboratory parameters in patients with arterial hypertension (AH) and Type 2 diabetes mellitus (DM-2) who received active antidiabetic treatment.Material and methods. In total, 122 patients with AH and DM-2 underwent the laboratory assessment of blood and urine samples at baseline and 12 months later, in order to evaluate the levels and dynamics of CVD RFs and CKD severity.Results. After 12 months of continuous therapy with antihypertensive and oral antidiabetic medications and statins, the carbohydrate metabolism parameters significantly improved. However, creatinine clearance decreased significantly (by 7,52%). The direction of renal function parameter changes was determined by the baseline CKD stage. Progressing CKD was also associated with obesity (O), atrial fibrillation (AF), and myocardial infarction (MI) in medical history. In patients with or without O, the albumin-creatinine ratio decreased by 59,8% and 34%, respectively. In participants with or without AF, microalbuminuria increased by 321% and decreased by 53,5%, respectively. In patients with MI in medical history, urine levels of creatinine decreased by 33,6%, while in the other patients, they increased by 5,4%. O was associated with a reduction in total cholesterol (TCH) by 5,5%, while in non-obese patients, TCH levels did not change substantially.Conclusion. In most patients with AH and DM-2, adequate glycemia control, standard antihypertensive treatment, and statin therapy for 12 months were associated with minimal changes in CVD RFs and with a significant deterioration in renal function. The latter was predicted by the CKD stage at baseline, O, MI in medical history, and AF.
ASSESSMENT OF MOTIVATIONAL AND COGNITIVE STATUS OF PRIMARY CARE CLINICIANS WHO TREAT METABOLIC SYNDROME PATIENTS
Authors: Kirichenko L. L. , Ovsyannikov K. V. , Fedoseev A. N. , Korolev A. P. , Budrik O. V. 
Published: August 2018

Recently, the clinicians’ attention has been driven to metabolic syndrome (MS), due to increasing prevalence and adverse prognosis of MS. The goal of the treatment of any chronic disease is the achievement of adequate therapeutic compliance which, in turn, is determined by motivational status of both clinicians and patients. The associations between clinicians’ motivation for long-term treatment, their knowledge levels, and the readiness to apply this knowledge in practice, on one hand, and the achievement of chronic disease compensation in patients, on the other hand, deserve further investigation.Aim. To analyse the readiness of primary care clinicians for the treatment of MS patients. The specific objective was to assess the district therapeutists’ knowledge, skills, and readiness to implement them in clinical practice while treating MS patients.Material and methods. The study included district therapeutists working at Moscow City polyclinics. In 2011-2013, the participants took continuous medical education courses at the Therapy Department No. 2, Post-diploma Medical Education Faculty, Moscow State Medico-Stomatological University. The doctors’ knowledge and skills were assessed in a questionnaire survey.Conclusion. The results obtained demonstrate inadequate readiness of district therapeutists for the treatment of MS patients.
THE INFLUENCE OF GLYCEMIA ON SHORT-TERM PROGNOSIS IN MYOCARDIAL INFARCTION WITHOUT ANAMNESIS OF 2ND TYPE DIABETES
Authors: Kholmatova K. K. , Dvoryashina I. V. , Supryadkina T. V. 
Published: August 2018

Aim. To estimate the impact of glycemia recorded during myocardial infarction (MI) in-patient care on short-term prognosis of patients without 2nd type diabetes mellitus (2DM).Material and methods. Totally 296 patients were prospectively investigated. According to glucose levels patients were divided into three groups: 1st with ≤4,0 mM/l (7,4%); 2nd with 4,01–7,79 mM/l (69,9%); 3rd with ≥7,8 mM/l (22,6%). The rate of glucose metabolism disorders and complications during in-hospital care were studied.Results. In 2/3 of patients with glycemia ≥7,8 mM/l at hospitalization, later the changes of glucose metabolism were found by glucosetolerance test: prediabetes (36,9%), 2DM (32,3%). In the patients of 3rd group significantly higher was the rate of 3-vessel disease (41,8%) anf MI complications: congestive left-ventricular failure — 52,2% vs 27,3% in the 1st group and 34,1% in the second (p=0,017), cardiogenic shock — 26,9% vs 4,5% and 6,8% (p<0,001), conduction disorders — 27,3% vs 9,1% and 11,7% (p=0,006), in-hospital mortality — 13,8% vs 4,5% and 4,4% (p=0,025). The risk of death in subjects with glycemia ≥7,8 mM/l was 3,48 (95% CI: 1,41–8,60) times higher than in normoglycemic (p=0,007). The glycemia was independently linked with complications of MI during in-hospital period: OR = 1,128; 95% CI: 1,005–1,266 (p=0,042), — as also with the age, severity of myocardial damage and systolic pressure at admittance.Conclusion. There was higher prevalence of MI complications and 3 times higher risk of death in patients without 2DM, but having ≥7,8 mM/l glucose (22,6% of patients) at admittance. The glycemia parameter was an independent predictor for unfavorable prognosis of MI without previous 2DM diagnosis and should be used as part of secondary prevention care.
THE COMPARISON OF ARRHYTHMOGENICITY OF DIFFERENT SURGICAL APPROACHES TO ATRIAL FIBRILLATION IN PATIENTS WITH CORONARY HEART DISEASE
Authors: Chernyavsky A. M. , Kareva Yu. E. , Pak I. A. , Rakhmonov S. S. , Romanov A. B. , Pokushalov E. A. 
Published: August 2018

Aim. To estimate the prevalence of iatrogenic atrial flutter in patients with coronary heart disease (CHD) and atrial fibrillation (AF) after two types of surgical operations: radiofrequency pulmonary veins isolation and radiofrequency modified mini Maze procedure; and to compare the results with control group of patients undergone aortic-coronary bypass grafting (CABG).Material and methods. Totally 95 patients included with CHD and persistent AF. Subjects were randomized into three groups: 1st (n=31) — with simultaneous CABG and radiofrequency ablation of pulmonary veins ostiums; 2nd (n=30) — simultaneous CABG and mini Maze procedure; 3rd control (n=34) — CABG only. For prolonged ECG monitoring the implanted devices Reveal XT were used in 53 subjects.Results. The patients escaped from left-atrial flutter were 90% in the 1st group. In the 2nd there was 1 case of left-atrial flutter (according to electrophysiological investigation — the leap through the mitral valve line), meaning 96,9% patients free from it. However there was no significant difference between 1st and 2nd groups (p=0,6). In the 3rd group postprocedure flutter developed in one case too, due to the scar on the left atrium wall after mitral valve regurgitation correction; so 97% patients escaped from flutter, but the difference was still not significant (p=0,4).Conclusion. In patients with CHD and AF it is recommended to perform radiofrequency modified mini Maze procedure combined with CABG due to its lower proarrhythmogenic effect. The rate of iatrogenic flutter is 3,1% after mini Maze and 10% after pulmonary veins ostiums isolation.
THE SENSITIVITY OF VASCULAR ENDOTHELIUM AND ITS PREDICTORS IN PATIENTS WITH CARDIOVASCULAR PATHOLOGY
Authors: Andreeva E. O. , Koryakina L. B. , Pivovarov Yu. I. , Kurilskaya T. E. 
Published: August 2018

Aim.To estimate the role of endogenous metabolic factors in formation of vascular endothelium reactivity in patients with different genesis cardiovascular regulation disorders.Materials and methods.The research included 30 patients with ischemic heart disease (IHD) with stable form of exertional angina (EA) of II–III severity class, 30 patients with I–II stage and 1st–2nd degree essential hypertension (EH), and 15 clinically healthy volunteers. We researched the signs of functional state of vascular endothelium before and after occlusion test. The parameters investigated included: adhesion of thrombocytes, spontaneous aggregation, prostacyclin activity of blood plasma, levels of antithrombine-III, of von Willebrand factor, contents of malonic aldehyde, of nitrites, of endothelin-1, of membrane-connected haemoglobin, of methaemoglobin in erythrocytes, activity of angiotensineconverting enzyme, level of sorption on the membrane of erythrocytes of nucleotides. Research of hemorheology was performed by viscosimetry method.Results.In healthy volunteers high probability of endothelium sensitivity to transverse strain decrease (in 82%) was determined and 25% increase of activity of peroxide oxidation of lipids. In patients with exertional angina influence of dynamic changes of blood flow on endothelium occurred by 2% decrease of viscosity and more than 120% increase of production von Willebrand factor (in 87%). It was concluded that as higher the production of prostacyclin in response to mechanic stimuli (more than 50%) is, the higher is probability of blood flow dynamic changes influence on endothelium. In patients with essential hypertension 30% increase of level of antithrombine-III in 100% of cases caused increase of sensibility of vascular endothelium to transverse strain.Conclusion.The most significant factors linked with sensibility of endothelium of vascular wall to dynamic blood flow changes in examined groups of patients were determined. In patients with exertional angina vascular reaction was mostly linked with rheological qualities and adhesive-aggregation characteristics of blood. In patients with essential hypertension the sensitivity of vascular endothelium was implied to be concordant with anticoagulant activity of blood plasma.
CARDIOVASCULAR DISEASES REGISTRY (RECVAZA): DIAGNOSTICS, CONCOMITANT CARDIOVASCULAR PATHOLOGY, COMORBIDITIES AND TREATMENT IN THE REAL OUTPATIENT-POLYCLINIC PRACTICE
Authors: Boytsov S. A. , Luk’yanov M. M. , Yakushin S. S. , Martsevich S. Yu. , Vorobyov A. N. , Zagrebelny A. V. , Pereverzeva K. G. , Pravkina E. A. , Deev A. D. , Andreenko E. Yu. , Ershova A. I. , Meshkov A. N. , Myasnikov R. P. , Serdyuk S. S. , Kharlap M. S. , Bazaeva E. V. , Kozminsky A. N. , Moseychuk K. A. , Kudryashov E. N. 
Published: August 2018

Aim.To study the structure of concomitant cardiovascular and comobid pathology, risk factors in patients with arterial hypertension (AH), coronary heart disease (CHD), with congestive heart failure (CHF) and atrial fibrillation (AF), and to evaluate the quality of diagnostics and treatment in the conditions of real outpatient-polyclinic practice by the Registry in Ryazanskaya region – a RF region with high level of cardiovascular mortality.Material and methods.Into the outpatient-polyclinic registry RECVAZA (Registry of cardiovascular diseases) totally 3690 patients included with AH, CHD, with CHF, AF and their comorbidity, who admitted physicians’ offices in 3 outpatient institutions in Ryazan city: 1047 (28%) males and 2643 (72%) females, mean age 66,1±12,9 y.o.Results.The AHG diagnosis was mentioned in 3648 (98,9%) patients: CHD – in 2548 (69,1%), CHF – 2726 (73,9%), AF – 530 (14,4%). In 79,5% cases there was comorbidity. In general each one patient had 2,6 diagnoses of 4 analyzed. Myocardial infarction and brain stroke were in 11,4% and 9,5% patients’ anamnesis; diabetes – in 19,1%. The level of investigation of patients did not match the expected level with cardiologic pathology. There was non-sufficient amount of investigations and drugs prescribed, especially ACE inhibitors and angiotensine receptor blockers in CHF patients, statins in CHD, beta-blockers in patients with myocardial infarction, anticoagulants in AF, though they had indications. At the moment of Registry, a discount rate of drug price had 16,7% patinets vs. 33,1% in previous years (p<0,0001).Conclusion.RECVAZA results revealed in AH, CHD, CHF and AF patients high prevalence of cardiovascular comorbidity, non-sufficient risk factors evelauation nad accordance to national and international guidelines for treatment – important and real gap for diagnostics and treatment quality improvement in AH, CHD, CHF, AF anf their concomitance.
uOttawa French Immersion Students' Linguistic Identities: The Duality of their Positionings
Authors: Durepos Jessica 
Published: August 2018

An important yet still relatively under researched area of research in immersion studies includes post-secondary immersion research and is increasingly warranted in order to better understand the student experiences of these student. The participants of this case study find themselves in a pivotal life moment as they are transitioning from the K-12 immersion education system to a bilingual post-secondary institution. During this transition, the study examines how Régime d'immersion en français students at the University of Ottawa position themselves and are positioned (Davies & Harré, 1990) towards Francophone language and culture. This study reports on the experiences of three first-year undergraduate students of the Régime d'immersion en français in regards to their linguistic identities. Do they consider themselves as Bilingual, Multilingual, Francophone, Francophile, Anglophone, or Other? Moreover, do their Francophone peers legitimize or challenge these self-ascribed positionings? The study exposes the factors which influenced the linguistic positioning of the participants and comments on patterns in the factors which affected their linguistic identity in particular.
Résumé
Un domaine de recherche important, mais encore relativement sous-étudié pour la recherche en immersion concerne la recherche sur l'immersion universitaire. Encore plus, il y a peu de recherche qui étudie les expériences de ces étudiants en immersion universitaire. Les participants de cette étude de cas se retrouvent dans une période turbulente de leur vie, alors qu'ils passent du système d'enseignement en immersion de la maternelle à la 12e année à un établissement d'enseignement postsecondaire bilingue. Durant cette transition, l'étude examine comment les étudiants du Régime d'immersion en français de l'Université d'Ottawa se positionnent et sont positionnés (Davies et Harré, 1990) vers la langue et la culture francophones. Cette étude met le point de mire sur les expériences d'apprentissage de trois étudiantes de première année du premier cycle du Régime d'immersion en français avec accent particulier sur leur identité linguistique. Se considèrent-elles comme bilingues, multilingues, francophones, francophiles, anglophones ou autres? De plus, leurs pairs francophones légitiment-ils ou contestent-ils ces positionnements autoproclamés? L'étude expose les facteurs qui ont influencé le positionnement linguistique des participantes et explore ces facteurs qui ont particulièrement influencé leurs identités linguistiques.
Backmatter
Authors: OLBI Working Papers Cahiers de l'ILOB / 
Published: August 2018

This file contains all the promotional materials about the OLBI Working Papers (a list of previous issues as well as a list of reviewers), the University of Ottawa's Official Languages and Bilingualism Institute and its Master of Arts in Bilingualism Studies (M.A.). It also includes a list of participants at the CCERBAL conference that took place in May 2017 under the title Immersion in higher education: Where do we stand today? as well as an announcement about an upcoming bilingual volume edited by Hélène Knoerr, Alysse Weinberg and Catherine Elena Buchanan to be published under the title Current issues in university immersion.