bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Trends Among US Surgeons in the Identification, Treatment, and Time of Repair for Medial Meniscal Ramp Lesions at the Time of ACL Surgery
Authors: DePhillipo Nicholas N. , Engebretsen Lars , LaPrade Robert F. 
Published: February 2019

Background: Given the potential hidden nature of medial meniscal ramp lesions and the controversy regarding treatment, it is important to understand the current trends regarding the identification and treatment strategies of meniscal ramp lesions by the leading surgeons and educators in the field of sports medicine. Purpose: To better understand the current trends in orthopaedic surgery regarding arthroscopic identification and treatment of medial meniscal ramp lesions at the time of anterior cruciate ligament (ACL) surgery. Study Design: Cross-sectional study. Methods: An electronic questionnaire was sent in a blinded fashion to 91 directors of orthopaedic sports medicine fellowship training programs in the United States. Participants’ email addresses were obtained through the American Orthopaedic Society for Sports Medicine directory of current fellowship program directors. Inclusion criteria were only those surgeons who currently performed ACL reconstruction surgery. Exclusion criteria were those surgeons who did not perform ACL reconstruction or who chose to opt out of the survey. Results: Overall, 19 surgeons opted out of the survey; 36 responded from the remaining 72 surveys (50%). The majority (n = 31, 86%) reported routinely checking for a medial meniscal ramp lesion via inspection of the posteromedial meniscocapsular junction during an ACL reconstruction. The most common repair technique cited was all-inside (n = 24, 66.7%), followed by inside-out (n = 8, 22.2%). Three (8%) surgeons indicated that they did not repair meniscal ramp lesions. Regarding surgical treatment (repair vs no treatment), the majority reported using the extent of the tear (89%; partial vs full thickness) and the stability of the tear upon probing (81%) as the main criteria for intraoperative decision making. Nineteen (52.8%) surgeons required a mean time of <15 minutes for meniscal ramp repair; 16 surgeons (44.4%), 15 to 30 minutes; and 1 surgeon (2.8%), 30 to 45 minutes. Conclusion: This study provides insight regarding meniscal ramp tear identification, treatment, and repair strategies from the fellowship directors of sports medicine orthopaedic surgery in the United States. Such information may be useful for current orthopaedic surgeons to advance their practice according to the current trends surrounding ACL reconstruction and medial meniscal ramp repair.
Prospective study of Burkitt lymphoma treatment in adolescents and adults in Malawi
Authors: Painschab Matthew S. , Westmoreland Kate D. , Kasonkanji Edwards , Zuze Takondwa , Kaimila Bongani , Waswa Peter , El-Mallawany Nader Kim , Tomoka Tamiwe , Mulenga Maurice , Montgomery Nathan D. , Fedoriw Yuri , Gopal Satish 
Published: February 2019

Abstract
Burkitt lymphoma (BL) is common in sub-Saharan Africa (SSA). In high-income countries, BL is highly curable with chemotherapy. However, there are few prospective studies from SSA describing nonpediatric BL and no regional standard of care. Thirty-five participants age 15 years or older with newly diagnosed BL were enrolled in Malawi from 2013 to 2018. Chemotherapy was administered according to institutional guidelines, with concurrent antiretroviral therapy if HIV infected. Median age was 21 years (range, 15-61) and 15 participants (43%) were HIV infected. Twenty-seven participants (77%) had stage III to IV disease, and 19 (54%) had Eastern Cooperative Oncology Group performance status &gt;1. Among HIV-infected participants, median CD4 count was 130 (range, 29-605) and 10 (67%) had suppressed HIV viral load. Four participants (11%) died before receiving chemotherapy. First-line chemotherapy consisted of: cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) (n = 22 [71%]); infusional etoposide, prednisolone, vincristine, cyclophosphamide, and doxorubicin (n = 4 [13%]); high-dose methotrexate-based chemotherapy (n = 4 [13%]); and rituximab plus CHOP (n = 1 [3%]). Among 28 evaluable participants, 14 (50%) achieved a complete response. Median overall survival (OS) was 7 months; 1-year OS was 40% (95% confidence interval [CI], 24%-56%). Sixteen (73%) of 22 deaths were a result of disease progression. Compared with CHOP, more intensive chemotherapy was associated with decreased mortality (hazard ratio, 0.24; 95% CI, 0.05-1.02; P = .05). This is among the best characterized prospective cohorts of nonpediatric BL in SSA. Most deaths resulted from progressive BL. Patients who received more intensive therapy seemed to have better outcomes. Defining optimal approaches is an urgent priority in SSA.
Ionic silver functionalized ovine forestomach matrix – a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications
Authors: Karnik Tanvi , Dempsey Sandi G. , Jerram Micheal J. , Nagarajan Arun , Rajam Ravindra , May Barnaby C. H. , Miller Christopher H. 
Published: February 2019

Abstract

Background
Antimicrobial technologies, including silver-containing medical devices, are increasingly utilized in clinical regimens to mitigate risks of microbial colonization. Silver-functionalized resorbable biomaterials for use in wound management and tissue regeneration applications have a narrow therapeutic index where antimicrobial effectiveness may be outweighed by adverse cytotoxicity. We examined the effects of ionic silver functionalization of an extracellular matrix (ECM) biomaterial derived from ovine forestomach (OFM-Ag) in terms of material properties, antimicrobial effectiveness and cytotoxicity profile.

Methods
Material properties of OFM-Ag were assessed by via biochemical analysis, microscopy, atomic absorption spectroscopy (AAS) and differential scanning calorimetry. The silver release profile of OFM-Ag was profiled by AAS and antimicrobial effectiveness testing utilized to determine the minimum effective concentration of silver in OFM-Ag in addition to the antimicrobial spectrum and wear time. Biofilm prevention properties of OFM-Ag in comparison to silver containing collagen dressing materials was quantified via in vitro crystal violet assay using a polymicrobial model. Toxicity of ionic silver, OFM-Ag and silver containing collagen dressing materials was assessed toward mammalian fibroblasts using elution cytoxicity testing.

Results
OFM-Ag retained the native ECM compositional and structural characteristic of non-silver functionalized ECM material while imparting broad spectrum antimicrobial effectiveness toward 11 clinically relevant microbial species including fungi and drug resistant strains, maintaining effectiveness over a wear time duration of 7-days. OFM-Ag demonstrated significant prevention of polymicrobial biofilm formation compared to non-antimicrobial and silver-containing collagen dressing materials. Where silver-containing collagen dressing materials exhibited cytotoxic effects toward mammalian fibroblasts, OFM-Ag was determined to be non-cytotoxic, silver elution studies indicated sustained retention of silver in OFM-Ag as a possible mechanism for the attenuated cytotoxicity.

Conclusions
This work demonstrates ECM biomaterials may be functionalized with silver to favourably shift the balance between detrimental cytotoxic potential and beneficial antimicrobial effects, while preserving the ECM structure and function of utility in tissue regeneration applications.
Evaluation of functional connectivity in subdivisions of the thalamus in schizophrenia
Authors: Gong Jinnan , Luo Cheng , Li Xiangkui , Jiang Sisi , Khundrakpam Budhachandra S. , Duan Mingjun , Chen Xi , Yao Dezhong 
Published: February 2019

BackgroundPrevious studies in schizophrenia revealed abnormalities in the cortico-cerebellar-thalamo-cortical circuit (CCTCC) pathway, suggesting the necessity for defining thalamic subdivisions in understanding alterations of brain connectivity.AimsTo parcellate the thalamus into several subdivisions using a data-driven method, and to evaluate the role of each subdivision in the alterations of CCTCC functional connectivity in patients with schizophrenia.MethodThere were 54 patients with schizophrenia and 42 healthy controls included in this study. First, the thalamic structural and functional connections computed, based on diffusion magnetic resonance imaging (MRI, white matter tractography) and resting-state functional MRI, were clustered to parcellate thalamus. Next, functional connectivity of each thalamus subdivision was investigated, and the alterations in thalamic functional connectivity for patients with schizophrenia were inspected.ResultsBased on the data-driven parcellation method, six thalamic subdivisions were defined. Loss of connectivity was observed between several thalamic subdivisions (superior-anterior, ventromedial and dorsolateral part of the thalamus) and the sensorimotor system, anterior cingulate cortex and cerebellum in patients with schizophrenia. A gradual pattern of dysconnectivity was observed across the thalamic subdivisions. Additionally, the altered connectivity negatively correlated with symptom scores and duration of illness in individuals with schizophrenia.ConclusionsThe findings of the study revealed a wide range of thalamic functional dysconnectivity in the CCTCC pathway, increasing our understanding of the relationship between the CCTCC pathway and symptoms associated with schizophrenia, and further indicating a potential alteration pattern in the thalamic nuclei in people with schizophrenia.Declaration of interestNone.
Dissecting cause from consequence: a systematic approach to thermal limits
Authors: MacMillan Heath A. 
Published: February 2019

ABSTRACT
Thermal limits mark the boundaries of ectotherm performance, and are increasingly appreciated as strong correlates and possible determinants of animal distribution patterns. The mechanisms setting the thermal limits of ectothermic animals are under active study and rigorous debate as we try to reconcile new observations in the lab and field with the knowledge gained from a long history of research on thermal adaptation. Here, I provide a perspective on our divided understanding of the mechanisms setting thermal limits of ectothermic animals. I focus primarily on the fundamental differences between high and low temperatures, and how animal form and environment can place different constraints on different taxa. Together, complexity and variation in animal form drive complexity in the interactions within and among levels of biological organization, creating a formidable barrier to determining mechanistic cause and effect at thermal limits. Progress in our understanding of thermal limits will require extensive collaboration and systematic approaches that embrace this complexity and allow us to separate the causes of failure from the physiological consequences that can quickly follow. I argue that by building integrative models that explain causal links among multiple organ systems, we can more quickly arrive at a holistic understanding of the varied challenges facing animals at extreme temperatures.
Purchase of medications without prescription in Peru: a cross-sectional population-based study
Authors: Hernández-Vásquez Akram , Alarcon-Ruiz Christoper A. , Díaz-Seijas Deysi , Magallanes-Quevedo Luisa , Rosselli Diego 
Published: February 2019

Background: Low availability of medicines in health services, self-medication, inadequate use of medicines, and inadequate dispensing practices in pharmacies are frequent problems in Peru. We aimed to evaluate how frequent the purchase of medications without medical prescription is in Peru, and which factors are associated with this practice. Methods: We conducted a secondary analysis of the 2016 ENSUSALUD national survey data. Purchase of one or more medicines that require a prescription was measured as a dichotomous variable. Crude and adjusted prevalence ratios (PR) and their 95% confidence intervals (95% CI) were calculated using Poisson regressions model with robust variance to assess the association of purchasing of medicines that require prescriptions with sociodemographic factors. Results: There were 3858 participants in the dataset. The prevalence of purchasing medications without prescriptions was 47.2%. History of having previously consumed the same medication (31.6%), and the delay in receiving an appointment at health facilities (26.9%) were the main reasons to buy medications without a prescription. Regarding the recommendation of the medication purchased, the advice of the pharmacy, and remembering a previous old prescription, were the most frequent reasons (38.3%, and 25.9%, respectively). On the multivariable analysis, users that buy medications without prescription were more likely to be of aged 25-44; reside in the Jungle and Highlands regions; and self-consumption of the purchase. Individuals with Seguro Integral de Salud (Comprehensive Health Insurance) were less likely to buy medications without prescription. Conclusions: There is a high prevalence of prescription requiring medication being bought without one from pharmacies in Peru. It is necessary to include the evaluation of consumer patterns to develop strategies with the aim to regulate the consumption of prescription drugs in the Peruvian population.
Interpreting Interactions in Linear Fixed-Effect Regression Models: When Fixed-Effect Estimates Are No Longer Within-Effects
Authors: Shaver J. Myles 
Published: February 2019

Fixed-effect regression models use within-firm variation to identify coefficient estimates, which is advantageous for mitigating certain endogeneity concerns and ruling out spurious relationships. I demonstrate that fixed-effect regression models with interaction terms (and by extension quadratic or higher-degree terms) confound within-firm and between-firm variation in identifying interaction coefficient estimates. Thus, in these specifications coefficient estimates lack a desirable property of standard fixed-effect estimates. I substantiate this concern using simulations and an empirical example. I also demonstrate how segmented regression aids assessing whether within-firm or between-firm variation identifies interaction coefficient estimates in fixed-effect models. The online appendix is available at https://doi.org/10.1287/stsc.2018.0065 .
“The Protestant Contention”: Religious Freedom, Respectability Politics, and W. A. Criswell in 1960
Authors: Miller Eric C. , Towns James E. 
Published: February 2019

AbstractThough rhetorical critics have been very attentive to John F. Kennedy’s rhetoric during the 1960 campaign, less attention has been paid to that of his conservative Protestant antagonists. To address the omission, this essay considers W. A. Criswell’s July 3, 1960 address, “George Truett and Religious Liberty,” portions of which were reprinted and widely distributed as a pamphlet titled Religious Freedom, the Church, the State, and Senator Kennedy. These texts, we argue, are exemplary of a larger Protestant strategy during the 1960 race. Because Kennedy’s candidacy had prompted fierce vitriol from the anti-Catholic Right, conservative Protestant leaders from across the denominational spectrum tempered their attacks so as not to alienate centrist voters. Their measured adoption of religious freedom arguments allowed them to occupy the respectable middle, assailing Kennedy’s Catholicism while parrying charges of religious bigotry. In Criswell’s rhetoric, we find a pure distillation of this strategy, identifying it as a species of respectability politics with enduring appeal—this time from the Right.
Reaction Kinetics in Conversion Process of Pineapple Leaves into Glucose
Authors: Muhaimin Muhaimin , Wulan Febriana Beta , Arfan Septian 
Published: February 2019

Abstract This research aimed to determine the reaction kinetics in the process of hydrolysis of pineapple leaves. The experiment was carried out at the temperature (60, 90, and 120 oC) and variation of acid catalyst concentration (0.1; 0.5 and 1 M) by observation reaction time every 30 min. The kinetics model of hydrolysis reactions of pineapple leaves has shown first order reaction with activation energy value to find the concentration of sulfuric acid successively: 0.1 M; -15420 KJ/mol; 0,5 M; 3173.8 KJ/mol; 1 M; 100.53 KJ/mol. The reaction rate constant which produced the highest glucose level was on the use of sulfuric acid at a concentration of 0.1 M at a temperature of 120 oC with glucose levels produced between 26.366.039 ppm to 155.510.778 ppm with k = 0.0106/min. Keywords: glucose; hydrolysis; kinetic model; pineapple leaves
A three-dimensional conducting network of rGO-in-graphite-felt as electrode for vanadium redox flow batteries
Authors: Wang Hongrui , Ling Wei , Chen Jizhong , Wang Zhian , Zeng Xian-Xiang , Hu Yongqing , Wu Xiongwei , Deng Qi , Chen Guanghui , Wu Yuping , Holze Rudolf 
Published: February 2019

AbstractGraphite felt (GF) with numerous merits has been widely used as electrode in all-vanadium redox flow batteries (VRFB), but its further application is still hindered by its intrinsically poor electrocatalytic activity. Herein, we propose a three-dimensional (3D) conducting network constructed with reduced graphene oxide (rGO) in the GF electrode via a two-step method. The 3D conducting network with abundant oxygen-containing functional groups in the GF is conducive to the transport of electrons between GF fibers and the electrochemical charge transfer to vanadium ions in the composite electrode; it can enhance the electrocatalytic activity and conductivity of GF. The VRFB using 3D rGO modified GF (mGF) electrode exhibited outstanding energy efficiency of 73.4% at a current density of 100 mA·cm−2, which is much higher than that with pristine GF (pGF) (65.4%); and better rate capability. These first results reveal that GF with 3D conducting network shows promising opportunities for the VRFB and other electrochemical flow systems
The interactional making of a “true transsexual”: Language and (dis)identification in trans-specific healthcare
Authors: Borba Rodrigo 
Published: February 2019

AbstractCan the transsexual subject speak in their own terms? This is the question this article addresses. Grounded on a Foucauldian genealogical approach to discourse analysis and on Goffmanian-inspired interactional analysis, it investigates how knowledge systems that pathologise transsexuality as a mental disorder get gradually embodied (and spoken) in consultations at a Brazilian gender identity clinic. The analysis follows the interactional history a trans woman had with the clinic’s psychologist and traces the intertextual links that connect various consultations in time. This series of encounters constitutes a socialisation trajectory during which the trans client is led to speak a language that is not hers in order to frame an identity performance within the diagnostic criteria for the identification of “true transsexuals”. The article, thus, contributes to three areas for the study of transgender and language: (1) it investigates how transsexual people are led to speak a language that is not their own (the problems of agency and trans-autonomy); (2) it points to the centrality of studying how others speak to transsexual people – a gap identified by Don Kulick but which remains under-investigated; and (3) it highlights the importance of language use for the design of trans-positive and trans-affirmative healthcare practices.
The linguistic expression of gender identity: Albania’s “sworn virgins”
Authors: Dickerson Carly 
Published: February 2019

AbstractThis article focuses on the linguistic aspects of the construction of masculine identities by theburrneshat(also known as “sworn virgins”) of northern Albania: biological females who have become “social men”. Unlike other “third genders” (Kulick, Don. 1999. Transgender and language: A review of the literature and suggestions for the future.GLQ: A Journal of Lesbian and Gay Studies5(4). 605622.), theburrneshatare motivated not by personal identity or sexual desire, but by the need to fulfill patriarchal roles within a traditional social code.Burrneshatdo not marry or engage in sexual relationships, and are thus seen as honorable and self-sacrificing (Young, Antonia. 2000.Women who become men: Albanian sworn virgins. Oxford & New York: Berg.). How doburrneshatconstruct and express their identity linguistically, and how do others engage with this identity? I examine the effects of social and linguistic factors on variation in the use of grammatical gender in the speech ofburrneshatand others in their communities. I find that choices in grammatical gender are linked to the speaker’s relationship toburrneshat, the grammatical context of the token, and whether the token is in oral or written language. An analysis of other gendered practices confirms language’s role in building masculine identities. Situated within a culture that embraces women becoming men, this study sheds light onto the linguistic practices used by speakers in the co-construction of gender.
Discourses of transnormativity in vloggers’ identity construction
Authors: Jones Lucy 
Published: February 2019

AbstractThis article investigates the construction of two transgender vlogger personas, providing insight into the prevalence of normative discourses which may be drawn on when constructing transgender identities. Many transgender people around the world rely on the internet as a source of information and guidance, with online video diaries (“vlogs”), in which young people record and chart their experiences of transition, playing a particularly important role. In this article, discourse from two popular transgender vloggers is critically analysed. It is found that the vloggers index identities which are broadly in line with what Lal Zimman terms the archetypal “true transsexual”, an ideological model of what it means to be “authentically” transgender. This corresponds with heteronormative, essentialist expectations of binary gender. The vloggers are shown to authenticate their own experiences by stating what is “typical” and positioning themselves as “experts”. Ultimately, it is argued that the version of transgender identity and experience that they put forward reproduces prevalent discourses of normative gender and sexuality.
Self-misgendering among multilingual transgender speakers
Authors: Simpson Lauren , Dewaele Jean-Marc 
Published: February 2019

Abstract
“Misgendering” is a term used broadly to mean referring to someone using the wrong gender. In the transgender context, it usually refers to cases where a transgender person is referred to using the gender assigned at birth, rather than according to gender presentation. Misgendering is sometimes a form of anti-trans aggression, but can also be accidental or otherwise unintended. “Self-misgendering”, where transgender speakers unintentionally misgender themselves, is apparently previously unstudied, seems mainly to occur in a foreign-language context, and may bear some similarity to language-interference effects observed in the study of multilinguals, a “first-gender effect” analogous to first-language effects. One may also hypothesise social gender bias, variable gender-identity, or similar factors. This article quantitatively surveys self-reported self-misgendering among multilingual transgender speakers to identify factors of correlation or causation. Using data and respondents’ comments from an online survey, it shows strong correlation between self-misgendering by full-time transgender speakers and (lack of) fluency in the language spoken, with no significant correlation to other linguistic or social gender-related factors. This suggests the self-misgendering phenomenon is primarily a fluency effect, independent of social or identity factors such as attitude to gender in language, attitude to being misgendered, or “default” masculine gender.