bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modern Aspects of Hypertensive Angioretinopathy
Authors: Moshetova L. K. , Vorobyeva I. V. , Dgebuadze A. 
Published: January 2019

This literature review is devoted to modern problems of hypertensive retinopathy with arterial hypertension, as well as hypertensive retinopathy in combination diseases. The latest world studies were analyzed. Particular attention is paid to the clinical disease characteristics at the present stage with the analysis of the arterio-venous ratio, optic nerve edema (with high blood pressure figures) using an automated system, vector analysis, suggesting a new arteriovenous classification, called Web Integration (Wivern). The modern pathogenesis of hypertensive retinopathy, namely the ratio of proangiogenic and anti-angiogenic factors, the role of inflammation (C-reactive protein), the role of endothelin-1, endostatin, interleukin-8 (IL-8), and the main fibroblast growth factor (bFGF ), angiogenin and uric acid. The special importance of fundus registration is reflected with the help of the newest equipment at high figures of arterial pressure in patients with hypertensive retinopathy. It is known that according to the World Health Organization (WHO), mortality rate from cardiovascular diseases is 31 %. Hypertension is the main risk factor for coronary heart disease, myocardial infarction, heart failure, stroke, kidney disease and early death. Questions of eye blood flow in hypertensive angioretinopathy in patients with arterial hypertension (AH) are covered. Hypertensive retinopathy (HR) is a retinal disease that is caused by a prolonged increase blood pressure (BP) and leads to a decrease in vision. The data of pathophysiology are analyzed (arterial hypertension (AH) leads to thickening of the vessels of the inner membrane (intima), to thickening of the medial membrane (media) — hyperplasia of the muscular tissue followed by hyaline degeneration with the development of sclerotic changes). The questions of modern diagnostics with retinal morphological status evaluation (OCT), detection of eye fundus condition with newest fundus camers, pathogenetic aspects are discussed. This review will help to prevent the development of more severe forms of hypertensive retinopathy. This information will allow us to identify the most significant indicators in the early diagnosis of hypertension angioretinopathy.
Blood Lead Levels and Healthy Complaint in Printing Workers of Unipress Surabaya
Authors: Humairo Mika Vernicia , Keman Soedjajadi 
Published: January 2019

Lead is found in the printing ink, it gets into the human body through skin absorption and ingestion. Blood lead level > 10 μg/dL causes health disturbances. The purpose of this study was analyzed blood lead level and healthy complaints in printing worker of Unipress Surabaya. This research was observational analytic with cross sectional approach. The subject was printing production process employees and administration employees. Population of production process employees were 10 people and administration employees were 7 people. Whereas, sample of production process employees were 9 and administration employees were 6. The determination of the sampling used simple random sampling. Data analyzed with chi-square test and t-independent test. Blood lead level of production process employees have ± SD = 6.16 ± 0.37 μg/dl, whereas the blood lead level of administration employees have ± SD = 6.0±0.18 μg/dl. Based on the results by t-independent test (p = 0.371) which indicated there was no difference blood lead level of production process employees and administration employees. Based on the test results by chi-square (p = 0.005) which indicated there was difference in central nervous system disturbances of study group and control group. It is concluded that blood lead level in printing worker of Unipress Surabaya are normal. Though it can suggested to use gloves while working, increase hygiene and sanitation behavior, reducing smoking habit, as well as routine health check up to see the blood lead leve
Two-year outcome of a patient after LASIK following SMILE lenticule in situ implantation to treat a rare complication
Authors: Zhao Jing , Shang Jianmin , Niu Lingling , Xu Haipeng , Yang Dong , Zhao Yu , Fu Dan , Zhou Xingtao 
Published: January 2019

Abstract
Background: To report a case of femtosecond laser-assisted in situ keratomileusis (FS-LASIK) following small incision lenticule extraction (SMILE) lenticule in situ implantation to treat a rare complication.
Case presentation: The hyperopic left eye of a 46-year-old patient with refraction of +7.75 diopters sphere (DS)/-1.25 diopters cylinder (DC)×5°and corrected distance visual acuity (CDVA) of 20/50 mistakenly underwent SMILE procedure for myopic astigmatism (-8.50DS/-1.50DC×175°) due to medical record error. The extracted lenticule was subsequently re-implanted in situ. After 8 months, the left eye underwent FS-LASIK to correct hyperopia and astigmatism （+5.0DS/-0.75DC×100°. Two years after FS-LASIK, corneal tomography showed no ectasia and microscopy revealed transparent cornea. The left eye obtained CDVA of 20/50 and the refraction was -0.75DS/-0.25DC×165°.
Conclusion: SMILE lenticule in situ implantation offers a solution for rare complications and correction of refractive error following lenticule re-implantation with FS-LASIK is feasible and effective.
Keywords: SMILE, Lenticule, Re-implantation, Complication
Protein carbonylation as a possible way to modulate breast cancer cell proliferation
Authors: Shakhristova E. V. , Stepovaya E. A. , Sadykova A. A. , Novitsky V. V. 
Published: January 2019

Introduction.High rates of cancer incidence and mortality worldwide dictate the necessity of developing new methodological approaches in understanding the molecular mechanisms of cancer progression associated with intracellular redox regulation imbalance.The objectiveof the study was to evaluate the role of protein carbonylation in regulating breast cancer cell proliferation under redox status modulation.Materials and Methods. In the intact breast cancer cells and in the cells cultured under redox status modulation using 5mM N-ethylmaleimide (an - SH group blocker) and 5 Mm 1,4-dithioerythritol (a thiol group protector), the concentration of thioredoxin and its carbonylated form was measured using Western blot analysis. The activity of thioredoxin reductase and the level of protein carbonyl derivatives were determined using spectrophotometry. Cell cycle phase distribution was evaluated by flow cytometry.Results and Discussion. Under the effect of N-ethylmaleimide, cell cycle arrest in the S-phase was confirmed by oxidative modification of proteins, including thioredoxin carbonylation. When culturing MCF-7 cells in the presence of 1,4-dithioerythritol, cell cycle arrest in the G0/G1 phases was associated with a rise in the concentrations of reduced thioredoxin and glutathione forms.Conclusion.The thioredoxin system and oxidative modification of proteins are involved in redox-dependent modulation of breast cancer cell proliferation. Studies in the area of redox proteomics offer great potential to seek molecular targets of malignant transformation of breast cells.
The level of sialic acids and imidazole compounds in the saliva of patients with lung cancer of different histological types
Authors: Belskaya L. V. , Kosenok V. K. 
Published: January 2019

In recent years, the possibility of using known and new tumor markers in primary and differential diagnosis of lung cancer has been actively studied.The purpose of the studywas to study the level of sialic acids, the total content of imidazole compounds and seromucoids in the saliva of patients with lung cancer, depending on the histological type of tumor.Material and Methods. Total of 478 people took part in in the case-control study. They were divided into 3 groups: the main group (lung cancer, n=218), the comparison group (nonmalignant lung pathologies, n=60) and the control group (conditionally healthy, n=200).Results.Patients with non-malignant lung pathologies exhibited increased levels of imidazole compounds and seromucoids and decreased levels of sialic acids. A statistically significant decrease in the level of sialic acids was observed in patients with non-small cell lung cancer. The concentration of imidazole compounds was significantly higher in all study groups, except for carcinoid tumors. The nature of the changes in the studied parameters were ambiguous and depended on both the histological type of the tumor and the stage of the disease, including the presence / absence of distant and regional metastasis.
The life path of professor Max Wilms (1867 – 1918)
Authors: Morgoshiya T. Sh. , Syroezhin N. A. 
Published: January 2019

The scientific activity of M. Wilms is characterized by a versatility of his surveys and breadth of research. M. Wilms contributed to the development of clinical surgery and oncology by proposing new methods for diagnosing and treating the main forms of malignant tumors of the genital organs and kidneys; he made a significant contribution to the practice of world medicine. M. Wilms conducted classical studies of teratoid tumors of the ovaries and testes, mixed tumors, kidney tumors. The tumor described by M. Wilms in 1899, is one of the most frequent malignant neoplasms in children, it usually occurs from 2 to 5 years, but it can be detected at any age, even in very old people. A talented scientist and teacher demanding of himself and his students, Max Wilms published over 130 scientific works, he was the only author of the vast majority of them.Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.
Speech disorders in young and preschool children
Authors: Yagunova K. V. , Gaynetdinova D. D. 
Published: January 2019

With every coming year more and more children suffer from speech problems, making their parents visit various specialists (pediatrician, neurologist, speech therapist, defectologist), who use their diagnostic techniques to detect speech disorders. The absence of a unified classification system and diagnostics leads to the late correction of speech disorders. The article considers main reasons for disturbances in normal speech development, risk factors of speech pathology, clinical manifestations of some types of speech disorders, various approaches to diagnosis and systematization of speech disorders.Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.
Analysis of clinical and immunological parameters in children with joint pathology
Authors: Spivakovskaya A. Yu. , Spivakvskiy Yu. M. , Chernenkov Yu. V. 
Published: January 2019

For the purpose of comparative analysis of clinical and immunological parameters in children with juvenile idiopathic arthritis (n=56) and reactive arthritis (n=22) we determined the concentration of individual Th1- (IL-1β, IL-6, INF-γ), Th2- (IL-4) and Th17- associated interleukins (IL-17) in the blood serum. We conducted clinical examination of the patients, taking into account the duration of the disease, the amount of drug therapy and indicators of functional status. The concentration of interleukins in the serum was determined by enzyme immunoassay using ready-made commercial kits. We found that the course of juvenile idiopathic arthritis and reactive arthritis is characterized by a certain unidirectionality of disorders in the system of Th1-and Th2-associated cytokines. There were indentified key correlations between the studied interleukins for the diseases concerned. We proposed an interrelated analysis of immunological activity indicators, which allowed simplifying the differential diagnostics of articular form of juvenile idiopathic arthritis and reactive arthritis.Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.
Potato ecological quality in the biologization of high-intensity technologies of its cultivation and irrigation
Authors: Бутов Алексей , Butov Alexey , Мандрова Анна , Mandrova Anna 
Published: January 2019

To reduce the accumulation of toxic substances in tubers in 2014–2016 the author studied biological methods of fertilizers application and plant protection in black earth forest-steppe region under the conditions of high-intensity potato cultivation technology along with drip irrigation. The introduction describes the importance of potato in the diet of population and lists the environmental issues that arise as a result of enhanced using of chemicals during crop cultivation. The doses of mineral fertilizers in experiments were introduced separately and in combination with a bioameliorant: 1) without fertilizers (control site); 2) N60P90K60; 3) N90P135K90;
4) N120P180K120; 5) biological ameliorant – white mustard, post-harvest green manure; 6) bioameliorant + N60P90K60; 7) bioameliorant + N90P135K90; 8) bioameliorant + N120P180K120. Chemical insecticide Aktara and biological preparations Fitoverm, Akarin were used to protect potatoes against Colorado potato beetles. Insecto-fungicide Celest was used to treat seed tubers against fungal diseases. During growing season the author used fungicides Profit Gold, Ridomil Gold against fungal diseases, against weeds – Zenkor and Remus. High yield of potato environmentally friendly considering nitrates was obtained by means of simultaneous application of N90P135K90 and white mustard green mass. Tuber yield was 40.4 tonnes per hectare compared to 22.7 tonnes per hectare on the control site, and nitrate content was 111.3 mg while maximum permissible concentration (MPC) is 250 mg/kg. According to MPC established in the Russian Federation, for childrenʼs and dietary nutrition fertilizer dose should not exceed N60P90K60 in combination with a bioameliorant and a biological plant protection system. Safety interval (period between plant treatment and harvesting) for chemical insecticides is 35–40 days; fungicides – 20 days; herbicides (depending on their type) – 55–70 days. The production of ecologically clean potato according to EU standards was achieved only by means of using post-harvest green manure as a fertilizer, applying biological insecticides and Celest preparation within the framework of protecting plants against pests and diseases.
Efficient maintenance method for water supply facilities focused on the carbonation of concrete
Authors: Fujita Masaki , Iwasaki Shoichi , Inoko Keinosuke , Hayashi Kenji 
Published: January 2019

Abstract
In water supply facilities such as distribution reservoirs, the inner surface of reinforced concrete (RC) tanks is often coated with resin paint or the concrete cover depth is increased to protect the concrete from surface deterioration. However, there is little published research on carbonation – one of the main causes of concrete deterioration – in relation to RC tanks, leaving room for improvement with regard to methods for preventing surface deterioration. This study discusses the impact of surface coating and environmental conditions on the carbonation rate of concrete based on a survey of the present state of RC tanks of the Sapporo Waterworks Bureau. Coating was found to have an inhibitory effect on carbonation. Because the carbonation rate of concrete used for the inside and outside of RC tanks was slow, the sufficient concrete cover depth to protect rebar from carbonation while in service was found to be 75 mm for RC tanks without coating.
Selenium in wastewater: fast analysis method development and advanced oxidation treatment applications
Authors: Mohapatra Dipti Prakash , Kirpalani Deepak M. 
Published: January 2019

Abstract
Selenium, a ubiquitous non-metal in nature, is potentially toxic to natural ecosystems due to its bioaccumulation potential. Due to increased monitoring and enforcement of selenium regulations, the need to be able to measure and treat selenium efficiently has taken on an increased importance. The principal aqueous forms of inorganic selenium are selenite (Se(IV)) and selenate (Se(VI)). Selenate, due to its high mobility and lack of affinity to conventional adsorbents, is typically much more difficult to treat and remove. To address both measurement and removal, an analytical method is reported for quantification of selenium in wastewater (WW) using UV-Vis spectrophotometer followed by removal studies using advanced oxidation processes (AOPs). Malachite green and azure blue were selected for colorimetric analysis using UV-Vis. Malachite green indicator showed the best results for analysis. The reported UV-Vis method was applied to establish the effect of AOPs on selenium removal. It was noted that all of the AOP treated samples showed removal of selenium and it was established that the UV-Vis method has a lower limit of detection at 2 mg/L. Further, through this study, it was found that the chemical cavitation yield and selenium removal efficiency peaked at low frequency ultrasound of 40 kHz.
Bioinformatics Study of RNA Interference on the Effect of HIF-1α on Apelin Expression in Nasopharyngeal Carcinoma Cells
Authors: Xu Gang , Li Xianming , Yang Dong , Wu Shihai , Wu Dong , Yan Maosheng 
Published: January 2019

Background:
HIF-1α can affect the apelin expression and participates in the
developments in cancers but the mechanism need to be explored further.

Objective:
This paper investigates apelin expression in nasopharyngeal carcinoma CNE-2 cells and
its regulation by hypoxia inducible factor-1α (HIF-1α) under hypoxic conditions.

Methods:
CoCl2 was used to induce hypoxia in CNE-2 cells for 12h, 24h and 48h. HIF-1α small
interference RNA (siRNA) was transfected into CNE-2 cells using a transient transfection method.
HIF-1α and apelin mRNA levels were detected by real time PCR. Western blot was used to
measure HIF-1α protein expression. The concentration of apelin in cell culture supernatant was
determined by enzyme linked immunosorbent assay (ELISA).

Results:
HIF-1α and apelin mRNA levels and protein expression in CNE-2 cells increased
gradually with increased duration of hypoxic exposure and were significantly reduced in HIF-1α
siRNA transfected cells exposed to the same hypoxic conditions.

Conclusion:
Apelin expression is induced by hypoxia and regulated by HIF-1α in CNE-2 cells.
Mitochondrial Dysfunction in Blood Platelets of Patients with Manic Episode of Bipolar Disorder
Authors: Hroudová Jana , Fišar Zdeněk , Hansíková Hana , Kališová Lucie , Kitzlerová Eva , Zvěřová Martina , Lambertová Alena , Raboch Jiří 
Published: January 2019

Objectives:
The bipolar affective disorder (BAD) pathophysiology is multifactorial and has
not been fully clarified.

Method:
We measured selected mitochondrial parameters in peripheral blood components. The analyses
were performed for patients suffering from a manic episode during remission and were compared
to those performed for healthy controls. BAD was clinically evaluated using well-established diagnostic
scales and questionnaires. Mitochondrial respiration was examined in intact and permeabilized
blood platelets using high-resolution respirometry. The citrate synthase (CS) and electron transport
system (ETS) complex (complex I, II, and IV) activities were examined in platelets.

Results:
The CS, complex II and complex IV activities were decreased in the BAD patients, complex I
activity was increased, and the ratio of complex I to CS was significantly increased. In the intact platelets,
respiration after complex I inhibition and residual oxygen consumption were decreased in the
BAD patients compared to the healthy controls. In the permeabilized platelets, a decreased ETS capacity
was found in the BAD patients. No significant differences were found between BAD patients in
mania and remission.

Conclusion:
Increased complex I activity can be a compensatory mechanism for decreased CS and
complex II and IV activities. We conclude that complex I and its abnormal activity contribute to defects
in cellular energy metabolism during a manic episode and that the deficiency in the complex's
functioning, but not the availability of oxidative phosphorylation substrates, seems to be responsible
for the decreased ETS capacity in BAD patients. The observed parameters can be further evaluated as
‘trait’ markers of BAD.
Nickel Sensitivity in Rosacea Patients: A Prospective Case Control Study
Authors: Çifci Nurşad 
Published: January 2019

Background:
Rosacea is a frequently seen chronic disease. Certain allergens, some foods
and beverages are known to trigger symptoms of rosacea.

Objective:
We aimed to assess if nickel sensitivity is more common in rosacea patients than the normal
population.

Method:
Fourty patients with rosacea and 40 healthy age and sex-matched volunteers were included in
the study. From European standard patch test series, test units with nickel were applied on the skin of
the upper back. According to the scheme of the International Contact Dermatitis Research Group
(ICDRG), test results were evaluated at 48th, 72th and 96th hours. Seven days later, reevaluation was
done for late reactions. Statistical analyses were done by using Statistics package for Social Sciences
(SPSS) 17 package program and p<0.05 was accepted as statistically significant.

Results:
Female/male ratio was 34/6 in patient group and 32/8 in control group. Mean age of the
patient group and the control group were 39.97±12.65 (18-65 years), 40.82±11.79 (19-68 years), respectively.
Age and sex distributions were found to be statistically similar. Nickel allergy in the patient
and control group was found to be 52.5%, 22.5% respectively and the difference between groups was
statistically significant (p=0. 006).

Conclusion:
Our results showed that there may be an association between nickel sensitivity and rosacea.
Nickel sensitivity may be one of the underlying pathology or a triggering factor of the rosacea.
Nickel restricted diet and avoiding the use of nickel-containing jewellery and piercings may extend the
remission periods.
Instantaneous Incident Detection System Based on Analysis of Acoustic Signal from Crash and Skid in Tunnel
Authors: Jang Jinhwan 
Published: January 2019

Introduction:An acoustic signal-based tunnel accident detection system was developed in this study. In a tunnel environment, the sound diffusion effect is minimized and thanks to that, discrimination of accident sounds (crash and skid) from other noises can apparently be accomplished.Discussion:The system is composed of three parts: algorithm, field device, and center system. To distinguish accident-related acoustic signals such as a crash or skid among various other sounds in a tunnel, a delicate algorithm that can discriminate those signals from other normal signals generated from moving vehicles was created.Conclusion:The developed algorithm processes acoustic signals to filter out noises and to identify accident-related signals. The field device, installed in a tunnel, collects analog sounds, transforms them into digital signals, and transmits the digital signals to the server in the tunnel traffic management center. Lastly, in the tunnel traffic management center, the acoustic signal processing algorithm described above, installed in a server system, can instantaneously detect accidents. Once confirmed by the system operators, the information on the detected accidents is intended to be provided to drivers following behind as well as relevant agencies to prevent secondary accidents and to respond promptly. The developed system was evaluated in a real tunnel environment using traffic accident sounds acquired from real crash tests. The detection rates were 95, 91, and 80% at distances of 10, 30, and 50 m, respectively with a detection duration less than 1.4 s. Compared to conventional detection systems using loop detectors or video images that have a long detection time of around 1 min, the developed system can be regarded as superior in that it has an extremely short detection time, which, of course, is one of the most important factors for automatic incident detection systems.