bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing Different Procedures for Calculating Flexural Cracking Toughness Using Edge‐Notched Disc Bend Specimen Under Modes I and III
Authors: Hoseini Seyed Omid , Sohrabi Mohammad Reza , Mousavi Seyed Roohollah , Ghasemi Mohammad , Aliha M. R. M. 
Published: December 2024

ABSTRACTThis research used 30%, 40%, 50%, and 60% coarse aggregates and 0.15%, 0.3%, and 0.45% wavy steel fibers to make end‐notched disc bend self‐compacting concrete specimens for calculating and comparing flexural cracking toughness index by ASTM C1609, JSCE SF‐4, and JG/T 472‐2015 methods under pure modes I and III. The variation trends of different procedures under pure mode I was more affected by coarse aggregates and fibers had no noticeable influence. But under pure mode III increasing both fibers and aggregates improved the flexural cracking toughness. The estimation of JG/T 472‐2015 method was better than other methods under pure mode I. In pure mode III, due to positive effect of fibers on the pre‐peak, peak, and post‐peak areas, the deflection exceeds 1 mm. Hence, calculating the area under the load–displacement curve is facilitated for the ASTM C1609 and JSCE SF‐4 methods up to L/150 deflections.
Heterogeneity in the effects of bank lines of credit on capital investment efficiency
Authors: Wu Wei‐Shao , Suardi Sandy 
Published: December 2024

AbstractThis paper explores the effects of bank lines of credit on corporate investment efficiency. Credit lines impact capital investment efficiency by influencing fundamental growth opportunities and non‐fundamental stock valuations in Tobin's Q. Furthermore, firms with credit lines reduce under‐investment, contributing to an overall improvement in investment efficiency. Although credit lines enhance capital investment efficiency, their positive impact diminishes during economic downturns, low market sentiment, and stringent lending standards. Firms characterized by specific traits, such as high financial constraints, high leverage, and short operating cycles, tend to derive greater benefits in capital investment efficiency through access to credit lines.
A Retrospective Study to Investigate the Relationship Between Body Mass Index and Hemodynamic Characteristics in Hypertensive Patients
Authors: Xiao Wenqi , Han Ping , Song Liping , Yang Jingwen , Zhou Lin , Deng Xiangning , Ma Zheng J. , Lang Yukun , Zhao Hai , Zhao Yuzhuo , Chen Hui , Zhang Wenjing , Huang Huixian , Sun Ningling 
Published: December 2024

ABSTRACTThe relationship between hemodynamic parameters and body mass index (BMI) in the context of blood pressure regulation in hypertension is unclear. Here, we analyzed data from 1368 uncontrolled hypertensive patients, including key hemodynamic indicators such as heart rate (HR), cardiac index (CI), arterial stiffness (AS), systemic vascular resistance index (SVRI), and thoracic blood ratio (TBR). In this cohort, the average BMI across all hypertension patients was 26.859 ± 3.897 (kg/m2), with obese patients (BMI ≥ 28 kg/m2) averaging 31.01 ± 2.87 kg/m2 and non‐obese (BMI<28 kg/m2) averaging 24.70 ± 2.28 kg/m2. Younger obese patients exhibited higher diastolic pressures than non‐obese peers (p < 0.01). Hemodynamic analysis showed obese patients had increased HR and SVRI but lower CI and AS (p < 0.01). Hypertensive males aged under 60 with obesity displayed a more prominent peripheral vascular phenotype (p < 0.05) and volemic phenotype (p < 0.01) than non‐obese males. Obese females aged under 60 showed a higher incidence of cardiac phenotype (p < 0.01). Across genders, obese hypertensive patients aged over 60 had a greater prevalence of volemic phenotype than non‐obese patients (p < 0.05, p < 0.01, respectively). BMI inversely correlated with CI and positively with SVRI across age and gender categories (p < 0.01). Taken together, we find that patients with hypertension exhibit diverse hemodynamic profiles, and BMI significantly correlates with hemodynamic parameters such as SVRI and CI. Our research identifies BMI as a valuable target for personalized hypertension treatment.
Role of Autophagy in Type 2 Diabetes Mellitus: The Metabolic Clash
Authors: Alanazi Yousef Abud , Al‐kuraishy Haydar M. , Al‐Gareeb Ali I. , Alexiou Athanasios , Papadakis Marios , Bahaa Mostafa M. , Negm Walaa A. , AlAnazi Faisal Holil , Alrouji Mohammed , Batiha Gaber El‐Saber 
Published: December 2024

ABSTRACTType 2 diabetes mellitus (T2DM) is developed due to the development of insulin resistance (IR) and pancreatic β cell dysfunction with subsequent hyperglycaemia. Hyperglycaemia‐induced oxidative stress and endoplasmic reticulum (ER) stress enhances inflammatory disorders, leading to further pancreatic β cell dysfunction. These changes trigger autophagy activation, which recycles cytoplasmic components and injured organelles. Autophagy regulates pancreatic β cell functions by different mechanisms. Though the exact role of autophagy in T2DM is not completely elucidated, that could be beneficial or detrimental. Therefore, this review aims to discuss the exact role of autophagy in the pathogenesis of T2DM.
S‐Nitrosylation of NOTCH1 Regulates Mesenchymal Stem Cells Differentiation Into Hepatocyte‐Like Cells by Inhibiting Notch Signalling Pathway
Authors: Wang Xuesong , Xu Yan , Wang Yue , Tang Xingkun , Zhou Xiaolei , Lu Wenming , Chen Wenjie , Li Lincai , Zhou Lin , Ye Junsong 
Published: December 2024

ABSTRACTThe differentiation of mesenchymal stem cells (MSCs) into hepatocyte‐like cells (HLCs) is considered one of the most promising strategies for alternative hepatocyte transplantation to treat end‐stage liver disease. To advance this method, it is crucial to gain a deeper understanding of the mechanisms governing hepatogenic differentiation. The study demonstrated that suppression of the intracellular domain release of the Notch pathway receptor via the γ‐secretase inhibitor N‐[(3, 5‐difluorophenyl)acetyl]‐L‐alanyl‐2‐phenylglycine‐1, 1‐dimethylethyl ester (DAPT) significantly promotes the expression of hepatocyte‐related genes and proteins in HLCs. Increased expression of intracellular inducible NO synthase (iNOS) during differentiation led to elevated endogenous NO production. Biotin switch assays revealed a gradual increase in S‐nitrosylation (SNO)‐NOTCH1 and a decrease in overall NOTCH1 expression during hepatogenic differentiation. The addition of the exogenous NO donor S‐nitrosoglutathione (GSNO) and the SNO inhibitor dithiothreitol (DTT) further demonstrated that the elevated expression of SNO‐NOTCH1 promotes the differentiation of MSCs into mature hepatocytes. Briefly, our results fully demonstrated that the modification of the extracellular domain of NOTCH1 by NO, leading to the formation of SNO‐NOTCH1, significantly promotes hepatogenic differentiation by inhibiting the Notch signalling pathway. Our study highlights the critical role of SNO‐NOTCH1 in regulating the Notch signalling pathway and offers new insights into the mechanisms driving this differentiation process.
Schisandrin B Inhibits LPS‐Induced Endometritis Through Attenuating Ferroptosis via AMPK/PGC1α/Nrf2 Signalling Pathway
Authors: Yu Jing , Li Xuewei , Zhou Min , Lu Min , Ruan Zheng , Zou Wenshuang , Yu Shaohui 
Published: December 2024

ABSTRACTEndometritis is one of the common reproductive diseases in human and animal. In recent years, a number of studies have found that Schisandra B (Sch B), as a natural Chinese medicine extract, has antioxidant, anti‐inflammatory and other biological activities. Based on the above, in this study, mice were used to conduct an in vivo experiment to investigate the effect and mechanism of Sch B on lipopolysaccharide (LPS)‐induced endometritis. Haematoxylin and eosin (H&E) staining was used to detect the pathological changes of uterine tissue and western blot was used to detect the expression levels of signalling pathways and key genes for ferroptosis. The results showed that Sch B significantly inhibited the pathological injury of uterine tissue, myeloperoxidase (MPO) activity, the activation of NF‐κB pathway and the production of TNF‐α and IL‐1β. Furthermore, Sch B effectively inhibited ferroptosis by inhibiting malondialdehyde (MDA) and iron production and promoting the expression of ferroptosis suppressor genes GPX4 and ferritin. In conclusion, Sch B inhibited LPS‐induced endometritis through alleviating inflammatory response and ferroptosis via AMPK/PGC1α/Nrf2 signalling pathway.
Extrusion‐Based 3D Printing Technology in Soy Protein‐Based Meat Analogs: A Review
Authors: Maxy Dianna , Khalid Nurul Izzah , Teh Huey Fang , Kamalbatcha Zainebbeevi , Sulaiman Rabiha , Noh Teh Ubaidah , Yong Seng Ping Amanda , Mohd Ramli Sharifah Hafiza 
Published: December 2024

ABSTRACTExtrusion‐based 3D printing technology has emerged as a promising method for developing soy protein‐based meat analogs, addressing the urgent demand for sustainable and nutritious alternatives to traditional meat sources. There is a growing global interest in soy protein‐based diets, driven by environmental sustainability, health, and animal welfare concerns. Extrusion‐based 3D printing involves pushing soy protein pastes through a nozzle to develop layers that build up into three‐dimensional objects and enable the production of structures closely mimicking the texture and appearance of real meat. Soy proteins, characterized by their high protein content and balanced amino acid profile, are ideal for producing meat‐like textures and flavors. This review explores the application of extrusion and 3D printing technologies in soy protein‐based meat analog production, emphasizing their potential to replicate the sensory qualities of animal meat. It discusses the advantages and challenges associated with these technologies, including the optimization of printing parameters for consistency and quality. Rheological studies are conducted to achieve smooth extrusion and proper layer formation whereas integrating fats, fibers, and natural flavors to enhance texture and taste. The review provides an overview of extrusion processes, highlighting rheological studies optimizing the flow behavior of soy protein pastes for effective 3D printing. Additionally, it examines textural studies aimed at mimicking the mouthfeel and bite of real meat, as well as printing performance evaluated through shape retention, layer resolution, structural strength, and printing accuracy. Consumer acceptance of soy protein‐based meat analogs is also discussed, highlighting the familiarity with soy products and the increasing demand for plant‐based alternatives. The review concludes by considering prospects for these technologies, focusing on innovations in extrusion and 3D printing, market trends, and evolving consumer preferences.
The Impact of Smoking on Ulcerative Colitis and Interaction With Family History: A Population‐Based Cohort Study
Authors: Ahn Hyeong Sik , Swan Heather , Kazmi Sayada Zartasha , Kim Young Shin , Hong Gahwi , Choi Seeun , Kang Taeuk , Kim Minjung , Cha Jaewoo , Hann Hoo Jae , Kim Hyun Jung 
Published: December 2024

ABSTRACTBackgroundThe impact of smoking on ulcerative colitis (UC) among Asian populations is controversial, and interactions between genetic factors and smoking are not well studied. We evaluated the association between smoking and UC and assessed interactions between smoking and family history.MethodsUsing the National Health Insurance database, we identified 5.5 million individuals from 2002 to 2019 with information on familial relationships and smoking history. Cox proportional hazard regression was used to examine the association between UC and current/former smoking and estimate familial risk. Interactions between family history and smoking were assessed on an additive scale using relative excess risk due to interaction (RERI).ResultsCurrent smoking was associated with a decreased risk of disease (hazard ratio [HR] 0.53 95% CI 0.49–0.56), whereas former smoking was associated with an increased risk (HR 1.62 95% CI 1.53–1.71), compared to nonsmokers. Familial risk was HR 7.51 (95% CI 6.68–8.48). The protective effect of current smoking was more pronounced among those with a family history, as their combined effect was lower than the sum of their individual risks (HR 4.37 vs. 7.55), whereas the harmful effect of former smoking was more prominent among this group, and their combined effect exceeded the sum of their individual effects (HR 10.20 vs. 8.57), indicating statistically significant interactions (RERI current: −3.18 95% CI −4.89 to −1.47; former: 1.63 95% CI −1.00–4.25).ConclusionThe effects of smoking on UC do not appear to differ between Asian and Western populations. Possible gene‐smoking interactions were observed but in opposing directions for current/former smoking.
Weighing the global built environment: High‐resolution mapping and quantification of material stocks in buildings
Authors: Haberl Helmut , Baumgart André , Zeidler Julian , Schug Franz , Frantz David , Palacios‐Lopez Daniela , Fishman Tomer , Peled Yoav , Cai Bowen , Virág Doris , Hostert Patrick , Wiedenhofer Dominik , Esch Thomas 
Published: December 2024

AbstractBuildings provide indispensable services for human well‐being, but their construction and use are responsible for a substantial fraction of societies’ resource requirements and greenhouse gas emissions. Mapping and quantifying the material stocks in buildings is a key research frontier in industrial ecology. Reliable and spatially highly resolved maps of material stocks in buildings worldwide are so far not available. Existing approaches based on nighttime light data allow large‐scale coverage, but their spatial resolution is usually ∼0.5–1 km. Other methods using light detection and ranging (LiDAR) and cadaster data achieve higher resolution and accuracy, but do not allow wall‐to‐wall mapping of large regions. Based on high‐resolution Earth Observation data combined with material intensity factors (kg per m3 of building volume), we quantify and map material stocks in buildings at the unprecedented resolution of 90 m globally. We distinguish 18 types of materials in five types of buildings. We find that global material stocks in buildings amount to 547 (391–672) Gt, approximately half of total global societal material stocks. We find highly unequal distributions of material stocks in buildings per capita and per unit area of each country. Our results agree well with previous detailed estimates of material stocks in buildings in dedicated regions or individual cities. Improved and harmonized material intensity factors emerge as a key research area for improving the accuracy of material stock maps. Our results are available as data products with high spatial and thematic resolution to facilitate future studies; for example, of secondary resource potentials. This article met the requirements for a gold‐gold JIE data openness badge described at http://jie.click/badges.
Linking regional MFA models: Understanding disparities within the global zinc cycle
Authors: Rostek L. , Loibl A. 
Published: December 2024

AbstractCircular economy and criticality assessments require comprehensive monitoring of anthropogenic material flows and stocks at a regional level. Therefore, this study presents a multiregional trade‐linked dynamic MFA model for zinc. The model covers the entire life cycle from mining to recycling for the regions China, Europe, North America, Latin America, and Asia. The dynamic approach allows the analysis of the development of the cycles from 1995 to 2020. The interregional trade is quantified at each life cycle stage by using the Comtrade database. Sensitivity analysis is applied to account for uncertainties in the exogenous data. The results reveal large regional disparities in the zinc industry. While China shows enormous growth, Europe has already reached a steady state in zinc consumption and anthropogenic stock. The current global consumption is strongly driven by China, leading to a strong increase of its zinc stock in use. However, Europe has the largest zinc stock in use, especially on a per capita basis. North America's zinc consumption is decoupled from its economic growth, as evidenced by the recent decline in its zinc stock in use. In terms of recycling, Europe shows the highest volumes and the best circular performance, as indicated by high recycling rates, partly due to the extensive use of more easily recyclable product types. In all regions, there is potential for increased recycling by treatment of zinc‐bearing steelmaking dusts. China's strict regulation successfully triggered large‐scale implementation of respective recovery processes, leading to increasing recycling rates. This article met the requirements for a gold‐gold JIE data openness badge described at http://jie.click/badges.
Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies
Authors: Markusson Sigurbjörn , Raasakka Arne , Schröder Marcel , Sograte‐Idrissi Shama , Rahimi Amir Mohammad , Asadpour Ommolbanin , Körner Henrike , Lodygin Dmitri , Eichel‐Vogel Maria A. , Chowdhury Risha , Sutinen Aleksi , Muruganandam Gopinath , Iyer Manasi , Cooper Madeline H. , Weigel Maya K. , Ambiel Nicholas , Werner Hauke B. , Zuchero J. Bradley , Opazo Felipe , Kursula Petri 
Published: December 2024

Abstract2′,3′‐Cyclic nucleotide 3′‐phosphodiesterase (CNPase) is an abundant constituent of central nervous system non‐compact myelin, and its loss in mice and humans causes neurodegeneration. Additionally, CNPase is frequently used as a marker antigen for myelinating cells. The catalytic activity of CNPase, the 3′‐hydrolysis of 2′,3′‐cyclic nucleotides, is well characterised in vitro, but the in vivo function of CNPase remains unclear. CNPase interacts with the actin cytoskeleton to counteract the developmental closure of cytoplasmic channels that travel through compact myelin; its enzymatic activity may be involved in adenosine metabolism and RNA degradation. We developed a set of high‐affinity nanobodies recognising the phosphodiesterase domain of CNPase, and the crystal structures of each complex show that the five nanobodies have distinct epitopes. One of the nanobodies bound deep into the CNPase active site and acted as an inhibitor. Moreover, the nanobodies were characterised in imaging applications and as intrabodies, expressed in mammalian cells, such as primary oligodendrocytes. Fluorescently labelled nanobodies functioned in imaging of teased nerve fibres and whole brain tissue sections, as well as super‐resolution microscopy. These anti‐CNPase nanobodies provide new tools for structural and functional studies on myelin formation, dynamics, and disease, including high‐resolution imaging of nerve tissue.image
Evaluation of the Participation of Brazilian Women in Research in Oral Pathology and Oral Medicine
Authors: Ferreira Luiz Miguel , Nascimento João Pedro Santos , de Sousa Árlen Almeida Duarte , de Oliveira Fabrício Emanuel Soares , Martelli Daniella Reis B. , Santos‐Silva Alan Roger , Martelli‐Júnior Hercílio 
Published: December 2024

ABSTRACTBackgroundDespite recent advancements, women still encounter significant challenges in various fields, including dentistry. However, the increasing interest in female participation in science acknowledges its fundamental role in the advancement of knowledge. This study aims to assess indicators of women's involvement in Brazilian research in the areas of Oral Pathology and Oral Medicine.MethodsThis cross‐sectional study evaluated 197 professionals affiliated with the Brazilian Society of Stomatology and Oral Pathology in 2023. Data were collected from publicly available Lattes curriculum and organized into three sets of information: researcher profile, scientific production and human resources formation. Both the data from the researcher's entire career and from the last 5 years (2019–2023) were assessed separately. Descriptive analyses of categorical variables were performed, while the Mann–Whitney test was employed to compare the numerical variables regarding researchers' gender.ResultsOf 197 professionals, 117 (59.4%) were female. Although there was no significant difference in scientific production between genders, men had more publications, received approximately twice as many citations, and exhibited higher H‐index values compared to women. Notably, women surpassed men in undergraduate student supervision, while men predominated in supervising master's and PhD students.ConclusionsThis study highlighted the relevance of female participation in Oral Pathology and Oral Medicine research in Brazil. However, disparities persist regarding women participation, especially in scientific article citations and postgraduate students' supervision.
Pharmacokinetics of pradofloxacin, florfenicol, and tulathromycin and response to treatment of steers experimentally infected with Mannheimia hemolytica
Authors: Foster Derek M. , Halleran Jennifer L. , Jacob Megan E. , Hempstead Stephanie , Borst Luke B. , Negrao Watanabe Tatiane T. , Enomoto Hiroko , Papich Mark G. 
Published: December 2024

AbstractBackgroundBovine respiratory disease (BRD) is an economically important disease in the beef industry, and a major driver of therapeutic antibiotic use. Pharmacokinetic data of these drugs is relatively limited in diseased animals.Hypothesis/ObjectiveTo determine the concentrations of pradofloxacin, florfenicol, and tulathromycin in the airways, plasma, and interstitial fluid (ISF) of steers with a clinically relevant model of bacterial respiratory disease.AnimalsTwenty‐four Holstein and Holstein/Jersey cross steers ranging in age from 6 to 15 months.MethodsA randomized, blinded clinical trial was performed. After transport stress, steers were inoculated with Mannheimia hemolytica to induce BRD. Upon onset of clinical disease, steers were treated with pradofloxacin, florfenicol or tulathromycin. Blood, ISF, and pulmonary epithelial lining fluid (PELF) samples were obtained for drug concentration determination. Clinical exams and thoracic ultrasound examinations were conducted daily. Animals were euthanized at the end of the study period to assess lung lesions.ResultsPradofloxacin Cmax in PELF was 0.81 μg/mL (CV = 49.02%) and penetration into the PELF was 203.58% (72%). Florfenicol Cmax in PELF was 2.94 μg/mL (42.1%) and penetration was 230.08% (78.82%). Tulathromycin PELF Cmax was 0.9 μg/mL (45.03%) and PELF penetration was 518.97% (56.59%).Conclusions and Clinical ImportanceThere are differences in penetration of the drugs into the ISF and PELF compared to one another and previous data from healthy steers demonstrating the effect of disease on the PK of these drugs.