bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turismo fluvial: una alternativa para fomentar la actividad turística en los municipios ribereños al río Magdalena. El caso del municipio de Suárez (Tolima, Colombia)
Authors: Galvis Rivera Nicolás 
Published: October 2018

Debido a su enorme aporte social, cultural y turístico, en las últimas décadas, los ríos han adquirido mayor relevancia en el sector. Esto se evidencia, especialmente, en las zonas rurales, gracias a que su belleza natural es única y se entreteje con el paisaje cultural y la cotidianidad de los ribereños. El objetivo de la investigación fue conocer los contextos y las potencialidades que ofrece el río Magdalena en el municipio de Suárez (Tolima) en lo que concierne al impulso del turismo fluvial en la región del Alto Magdalena, departamento del Tolima. Para el levantamiento de la información se emplearon cuatro técnicas: observación de campo, entrevista y comunicación oral, encuesta y técnicas de grupo. Adicionalmente, se realizó una caracterización de los atractivos turísticos y una evaluación de las variables que integran el producto turístico, para determinar si Suárez es un destino potencial, emergente o consolidado.
El hilo conductor de la investigación fue la planificación territorial del turismo, junto con el enfoque teórico de la valorización turística, en el que se analiza el turismo como un fenómeno social complejo y como medio para brindar oportunidades de trabajo y calidad de vida a los pobladores que habitan la ribera del río Magdalena.
Lineamientos estratégicos para la gestión del turismo en el Distrito de Buenaventura (Colombia)
Authors: Arboleda Montaño Nixon 
Published: October 2018

El presente trabajo de investigación propone lineamientos estratégicos para la gestión del turismo en el Distrito de Buenaventura. Para lo anterior, se parte de la realización de un diagnóstico, el cual incluye un análisis de las dimensiones ambiental, social, económica y político-institucional. También se realizan cuatro análisis: de la situación turística, de la oferta turística, de la demanda y uno dofa, en el que se destacan las principales debilidades, oportunidades, fortalezas y amenazas del turismo en Buenaventura. Con respecto al inventario de atractivos turísticos, se resaltan los principales atractivos turísticos naturales y culturales que tiene el Distrito, con su debida descripción y definición de importancia evidenciada en la clasificación y el nivel de jerarquía que se le otorga a cada atractivo de acuerdo con las metodologías cicatur/oea y del Ministerio de Comercio, Industria y Turismo (2010). Finalmente, se establecen las áreas de acción, las estrategias, las acciones, los responsables y el tiempo que permitirán materializar los lineamientos estratégicos para la gestión del turismo en Buenaventura. Se espera que su implementación conduzca a mejorar la actual situación que el Distrito de Buenaventura tiene en esta materia.
Racionalidad crítica y conocimiento del turismo
Authors: Muñoz de Escalona Francisco 
Published: October 2018

Aunque haya quien lo ignore, incluso quienes lo obvien, lo que llamamos realidad no deja de ser un mero constructo teórico. Los hombres –y también las mujeres, claro– consiguieron nombrar pronto lo que con sus cinco sentidos perciben. Por eso, el Génesis acierta al afirmar que al principio fue el Verbo, quiso decir, la palabra. Acertó de plano el vetusto profeta. Gracias a su enseñanza sabemos lo que vemos, tocamos, olemos, gustamos y oímos. Pero la humanidad no quedó estancada en sus primeras nominaciones. Al ritmo de su lenta evolución, y de sus crecientes necesidades, las sometió a una crítica tenaz. De ella proceden el avance del conocimiento, en general, y el científico, en particular. La realidad a la que llamamos turismo no queda al margen de este proceder. Por ello, hoy disponemos de planteamientos críticos que han dado luz a interpretaciones (teorías) sometidas, como todas, al proceso de proposición, selección y eliminación de error, para volver a iniciar el proceso en un ciclo sin fin.
Native Adult Hip with Bacterial Septic Arthritis
Authors: Lum Zachary C. , Shieh Alvin K. , Meehan John P. 
Published: October 2018

* Adult septic arthritis of the native hip can be difficult to diagnose; often, care is delayed >24 hours, which may result in a failure to preserve the joint.* Treatment options include aspiration, open and arthroscopic irrigation and debridement, and resection arthroplasty with an antibiotic spacer and subsequent total hip arthroplasty.* Risk factors for repeat irrigation and debridement include inflammatory arthritis, diabetes, synovial cell count of >85,000 cells/mL, and Staphylococcus aureus infection.* Ten percent of patients undergoing resection arthroplasty and use of an antibiotic spacer may need an exchange spacer.* Outcomes after use of an antibiotic spacer and staged total hip arthroplasty can be highly successful and rewarding.
Cordycepin in Anticancer Research: Molecular Mechanism of Therapeutic Effects
Authors: Khan Md. Asaduzzaman , Tania Mousumi 
Published: October 2018

Background:Cordycepin is a nucleotide analogue from Cordyceps mushrooms, which occupies a notable place in traditional medicine.Objective:In this review article, we have discussed the recent findings on the molecular aspects of cordycepin interactions with its recognized cellular targets, and possible mechanisms of its anticancer activity.Methods:We have explored databases like pubmed, google scholar, scopus and web of science for the update information on cordycepin and mechanisms of its anticancer activity, and reviewed in this study.Results:Cordycepin has been widely recognized for its therapeutic potential against many types of cancers by various mechanisms. More specifically, cordycepin can induce apoptosis, resist cell cycle and cause DNA damage in cancer cells, and thus kill or control cancer cell growth. Also cordycepin can induce autophagy and modulate immune system. Furthermore, cordycepin also inhibits tumor metastasis. Although many success stories of cordycepin in anticancer research in vitro and in animal model, and there is no successful clinical trial yet.Conclusion:Ongoing research studies have reported highly potential anticancer activities of cordycepin with numerous molecular mechanisms. The in vitro and in vivo success of cordycepin in anticancer research might influence the clinical trials of cordycepin, and this molecule might be used for development of future cancer drug.
Profile of HBV Integration in the Plasma DNA of Hepatocellular Carcinoma Patients
Authors: Li Weiyang , Cui Xiaofang , Huo Qing , Qi Yanwei , Sun Yuhui , Tan Meihua , Kong Qingsheng 
Published: October 2018

Background:
Hepatitis B Viral (HBV) infection is one of the major causes of Hepatocellular
Carcinoma (HCC). Mounting evidence had provided that the HBV integration might be a critical
contributor of HCC carcinogenesis.
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Objective and Methods: To explore the profile of HBV integration in the plasma DNA, the method of
next-generation sequencing, HBV capture and bioinformatics had been employed to screen for HBV
integration sites in the plasma samples.

Results:
In the initial experiment, a total of 87 breakpoints were detected in the 20 plasma samples.
The distribution of breakpoints showed that there was significant enrichment of breakpoints in the region
of intron. Furthermore, the HBV breakpoints were prone to occur in the region of X protein
(1,700-2,000bp) in the plasma samples. The pathway analysis had revealed that the HBV integrations
sites were specifically enriched in the cancer pathway.

Conclusion:
Altogether, our results had provided direct evidence for the HBV integration in plasma
DNA, and they might be potentially useful for future HCC prognosis and diagnosis.
Effect of the Interaction Between Hypertension and Cerebral White Matter Changes on the Progression of Alzheimer Disease
Authors: Chou Ping-Song , Kao Yi-Hui , Wu Meng-Ni , Chou Mei-Chuan , Chen Chun-Hung , Lin Ruey-Tay , Yang Yuan-Han 
Published: October 2018

Background:
Cerebrovascular pathologies and hypertension could play a vital role in Alzheimer
disease (AD) progression. However, whether cerebrovascular pathologies and hypertension accelerate
the AD progression through an independent or interaction effect is unknown.

Objective:
To investigate the effect of the interactions of cerebrovascular pathologies and hypertension
on AD progression.

Method:
A retrospective longitudinal study was conducted to compare AD courses in patients with different
severities of cerebral White Matter Changes (WMCs) in relation to hypertension. Annual comprehensive
psychometrics were performed. WMCs were rated using a rating scale for Age-related WMCs
(ARWMC).

Results:
In total, 278 patients with sporadic AD were enrolled in this study. The mean age of the patients
was 76.6 ± 7.4 years, and 166 patients had hypertension. Among AD patients with hypertension,
those with deterioration in clinical dementia rating-sum of box (CDR-SB) and CDR had significantly
severe baseline ARWMC scales in total (CDR-SB: 5.8 vs. 3.6, adjusted P = 0.04; CDR: 6.4 vs. 4.4, adjusted
P = 0.04) and frontal area (CDR-SB: 2.4 vs. 1.2, adjusted P = 0.01; CDR: 2.4 vs. 1.7, adjusted P <
0.01) compared with those with no deterioration in psychometrics after adjustment for confounders. By
contrast, among AD patients without hypertension, no significant differences in ARWMC scales were
observed between patients with and without deterioration.

Conclusion:
The effect of cerebrovascular pathologies on AD progression between those with and without
hypertension might differ. An interaction but not independent effect of hypertension and WMCs on
the progression of AD is possible.
Curry Leaf and its Antioxidant Potential: A Systematic Study to Enhance its Activity in Aqueous Medium
Authors: Kumari Deepa , Mallick Tamanna , Karmakar Abhijit , Mondal Samiran , Das Sreeparna , Begum Naznin Ara 
Published: October 2018

Background:We have done a systematic study on the antioxidant activity of the methanol and petroleum ether (60-80°C) extracts (MEC and PEC respectively) of Curry leaves (Murraya koenigii Spreng. Family: Rutaceae) using various in-vitro chemical methods.Methods:Both of these two extracts were found to be highly efficient in the formation of Ag and Au nanoparticles. So, we have explored their ability to form the nanoparticles to study their antioxidant activity. In all the assay systems, MEC showed higher activity over PEC in aqueous medium. This may be due to the higher solubility of MEC and its active components, like polyphenols and flavonoids in the aqueous medium. PEC contains lesser amount of these water soluble active components but PEC was rich in carbazole types of alkaloids which are hydrophobic in nature. So, to enhance the antioxidant activity of PEC and its carbazole constituents, like 2-hydroxy carbazole and mahanimbine, we have encapsulated these in the biopolymeric matrix of the mucilage isolated from an edible vegetable, Abelmoschus esculentus L. (commonly known as Lady's finger, family: Malvaceae).Results:It was interesting to note that, PEC and its carbazole compounds showed better antioxidant activity (ferrous ion chelation and ferric reducing antioxidant activity) in aqueous medium after this encapsulation process.Conclusion:The protocols used in the present study were very simple and can be implemented in any lab set-up. In future, this work can be extended to evaluate antioxidant potentials of other plant based materials.
Risk Assessment of Sulphite Exposure through Foods Among Adolescents of Delhi (India)
Authors: Jain Arushi , Mathur Pulkit 
Published: October 2018

Background:Sulphites added as preservatives in food have been associated with adverse health effects in humans.Objective:The present study was designed with an objective of assessing the risk of sulphite exposure through food in adolescents (12-16 years old) of Delhi, India.Methods:A total of 1030 adolescents selected from four private and four government schools of Delhi, were asked to record their food intake using a 24 hour food record, repeated on three days, for assessing exposure to sulphites. The risk was assessed using six different scenarios of exposure.Results:The actual intake for sulphites for average consumers was 0.15 ± 0.13 mg / kg b.w. / day which was 21.4% of acceptable daily intake (ADI). For high consumers (P95), it was 65% of the ADI. However, for 2 respondents, the actual intake exceeded the ADI. The major food contributors to sulphite intake were beverage concentrates (46%), ready to serve beverages (22%) followed by miscellaneous food items (16%), mainly ice creams and snowballs. Estimation of sulphite intake using different exposure scenarios revealed that for certain scenarios where the highest reported sulphite level or maximum permissible levels were considered for calculation, the high consumers exceeded the ADI, though, for average consumers, intake was well below the ADI.Conclusion:Actual intake of sulphite for average consumers was well below the ADI but for high consumers was approaching the ADI. People with sulphite sensitivity need to be aware of hidden food sources of sulphites.
Biochemical and Pharmacological Applications of Essential Oils in Human Health Especially in Cancer Prevention
Authors: Ishfaq Pir Mohammad , Shukla Archana , Beraiya Satyaprakash , Tripathi Swati , Mishra Siddhartha K. 
Published: October 2018

Background:
Essential oils (EOs) are aromatic, volatile and concentrated hydrophobic liquids extracted
from plant material. EOs are also called as ethereal oils, volatile oils or aetherolea. EOs also play a crucial
role in plant defence and signalling processes. They are mostly used in perfumes, cosmetics, soaps and other
products for flavouring food, drinks, adding scents to incense and household cleaning products. EOs have a long
medicinal history.

Methods:
Reported research literature and online contents related to the use of EOs for their biochemical pharmacological
applications in cancer prevention therapy were reviewed. The most relevant and updated citations
were included in this review.

Results:
This review elaborates the various types of EOs, their biochemical characteristics, and pharmacology.
Medicinal benefits of essential oil products range from various skin treatments to different types of therapies for
cancer and are dependent entirely on historical backgrounds of use of EOs for these properties. EOs have antimicrobial,
anticancer, antioxidant, antiparasitical, insecticidal, anti-inflammatory, viricidal, fungicidal, wound
healing, antihypertensive, analgesic properties and other medicinal properties. The efficiency of EOs in medical
treatments and treatment of cancers are these days a subject of interest in most countries.

Conclusion:
This review elaborated the potentials of EOs in regulating cancer cell growth and have explored the
probable EOs that can be used in drug development.
Review on the Characteristic, Properties and Analytical Methods of Cefquinomesulphate: ß-lactam Veterinary Drug
Authors: Shantier Shaza W. 
Published: October 2018

Background:
Chemotherapy as a science began within the 1st decade of the twentieth
century with understanding of the principles of selective toxicity, the particular chemical relationships
between microorganism pathogens and medicines, the event of drug resistance, and also the
role of combined medical aid.

Objectives:
This review aims to highlight the characteristics, specifically the pharmacokinetic parameters
and the analytical methods reported in literature for the determination of Cefquinome, a
fourth generation cephalosporine used to treat Gram-positive and Gram-negative caused infections.

Conclusion:
Analysis of such drugs, whether used for the treatment of human or animal illness, is
essential in understanding the bioavailability and therapeutic control which will ensure their activity
and safety.
Murine Skin-resident γδT Cells Impair the Immune Response to HSV in Skin
Authors: Fernandez Marian A. , Yu Uet , Ferguson Angela L. , Wang Dongwei , Francis Elise , Roediger Ben , Weninger Wolfgang , Cantrill Laurence C. , Cunningham Anthony L. , Alexander Stephen I. , Jones Cheryl A. 
Published: October 2018

Background:
HSV is an important cause of brain infection. Virus entry is often
through breeches in the skin. γδT cells play an immunoprotective role in mice after corneal, genital
or footpad (subcutaneous) HSV infection.

Methods:
Here we report that the presence of γδT cells in murine skin is associated with increased
severity of herpetic disease, reduced protective cytokine responses and increased viral spread from
the skin to the sensory ganglia in the zosteriform model. γδT cell-deficient (TCR δ -/-) mice displayed
significantly decreased herpetic lesion severity after flank HSV infection compared to WT
C57BL/6 controls at both primary and secondary skin infection sites.

Results:
Viral titer at the primary skin site was similar to WT mice in γδT cell-deficient mice, but
was significantly decreased in the ganglia and secondary skin site. γδT cell-deficient mice showed
increased Th1 responses by both T cells and non-T cells at the primary site, and decreased T-cell
Th17 responses and immune infiltration at the secondary site.

Conclusion:
Cytokine responses of epidermal and dermal γδT cells to HSV also differed in WT
mice (Th1 in epidermis, and Th17 in the dermis), suggesting a functional dichotomy between
these two subsets. Our data suggest that in contrast to other mouse models of HSV infection, skinresident
γδT cells promote the pathogenesis of HSV in skin.
Chronic Inflammatory Demyelinating Polyneuropathy in Systemic Lupus Erythematosus: A Rare Entity
Authors: Mohd Rozita , Nordin Fatimah Zanirah , Cader Rizna 
Published: October 2018

Background:Neurological manifestations in Systemic Lupus Erythematous (SLE) varies and commonly affects the Central Nervous System (CNS) rather than the peripheral nervous system. Neuropsychiatric or CNS manifestation can be as high as 24-54%, whereas the peripheral nervous system involvement is lower around 5-27%. Chronic Inflammatory Demyelinating Polyradiculopathy (CIDP) is one of the three commonest peripheral nervous system involvements in SLE patients and results with severe debilitating effects. However, it is rarely reported.Methods:A retrospective review of all SLE patients that were diagnosed with CIDP between 2000 and 2015 was done under follow up at our center that were diagnosed with CIDP between 2000 and 2015. We reviewed their medical records and analyzed their clinical presentation, investigations, treatment instituted, response to therapy and any neurological sequealae.Results:A total of 512 case notes were reviewed. Of these 4 patients presented with CIDP (3 females, 1 male) aged between 26 to 46 years old. Three presented with transverse myelitis and the other one with acute motor and sensory axonal neuropathy. All patients were treated with high dose corticosteroids, three patients received cyclophosphamide whilst the other patient was induced with mycophenolate mofetil. Complete recovery was seen in one patient, two had persistent but improving numbness and the other one had a residual weakness.Conclusion:Peripheral nervous system involvement in SLE can result in serious debilitating effects. Early diagnosis and treatment are crucial in limiting the neurological sequealae.
CdSe Quantum Dots to Quantum Rods: Transition Studies and Evaluation of Sensitivity as Transducers for Biosensing Glucose
Authors: Saran Amit D. , Bellare Jayesh R. 
Published: October 2018

Background:
The estimation of glucose level in the blood serum, has been widely used as a
clinical indicator of diabetes. Optical and electrochemical sensing of glucose widely uses Glucose Oxidase
(GOD) enzyme, as the catalyst for glucose oxidation, which releases hydrogen peroxide (H2O2). Optical
biosensors are superior to their electrochemical counter-parts as they are resistant to electromagnetic
interference, easier to fabricate into a microdevice and require low power supply. The quantum-dot-based
biosensors work on the phenomenon of fluorescence quenching following the release of H2O2.

Methods:
The CdSe nanoparticles are prepared in two series by room-temperature microemulsion
method. In series A, only AOT surfactant is used to synthesize spherical CdSe nanoparticles. In series B,
the mixed surfactant system of AOT and lecithin is used to synthesize anisotropic CdSe. The morphology
and crystallography is studied as the CdSe shape changes from spherical to rod-like. As the CdSe
nanoparticles are studied from spherical to rod-like morphology, the transducing sensitivity of these
nanoparticles is evaluated with respect to glucose biosensing. The effects of size and shape are studied,
based on the fluorescence quenching by H2O2 solutions. The sensitivity of proposed nanoparticles, is
evaluated as a function of size, shape, surface area and number concentration of CdSe nanoparticles.

Results:
The spherical CdSe nanoparticles are found to increase in size as R(water-to-surfactant ratio) is
increased from 4 to 12, in series A. Also, the aspect ratio of CdSe nanoparticle is found to increase from
4.2 to 12.8 as the ratio of AOT to lecithin is varied from 1:0.5 to 1:3. The decrease in sensitivity index is
seen with increasing surface area for both series A and B. The sensitivity is decreasing again with increasing
maximum dimension of the CdSe nanoparticle in the dispersion. While the trend is reverse in
case of the number concentration for CdSe nanoparticles synthesized in series B.

Conclusion:
From the data presented, it can be safely concluded that the sensitivity indices for series A
are better than those for series B, for the same values of a) the total surface area of CdSe nanoparticles, b)
total number concentration, and c) maximum dimension of CdSe nanoparticles. Also, the single surfactant
system (series A) is simple, cheaper and more reproducible to synthesize the CdSe nanosheres, as compared
with the mixed surfactant system forming CdSe quantum rods (series B). With these points, it is reasonable
to report that CdSe spherical QDs are better candidates for glucose biosensing, as compared to
CdSe quantum rods.
Fabrication of Chitosan/Pectin/PVA Nanofibers Using Electrospinning Technique
Authors: Safari Javad , Esteghlal Sara , Keramat Malihe , Khalesi Mohammadreza 
Published: October 2018

Background:
Electrospinning is a novel cost effective technique for generating nanofibers from a
broad range of materials likely to be used as a coating film.

Methods:
In this project, pectin and chitosan solutions containing PVA were prepared and electrospun with
separate syringes for the first time. The antimicrobial and physical properties of the novel chitosan/PVApectin/
PVA nanofibrous film were evaluated using some analysis techniques such as disc diffusion assay,
scanning electron microscopy (SEM), transmission electron microscopy (TEM), viscosity and conductivity
tests, and fourier-transform infrared spectroscopy (FTIR).

Results:
The results showed that simultaneously electrospinning the dispersion of chitosan/PVA (50:50)
with pectin/PVA (50:50) led to the formation of thin nanofibers with the minimum number of beads. The results
of FTIR analysis proved the dispersion of chitosan and PVA in nanofiber mats and the interaction of
chitosan with pectin as well as PVA with pectin. Disc diffusion assay showed that nano-film could possess
significant antibacterial activity against S. aureus at 37°C but had no effects against E. coli.

Conclusion:
Based on the results of this study, the novel chitosan/PVA-pectin/PVA nanofibrous film can be
considered as a novel coating film for promising application in food packaging industry.