bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Vectored Thermal Pulsation and Warm Compress Treatments in Meibomian Gland Dysfunction: A Meta-Analysis of Randomized Controlled Trials
Authors: Pang Shin-Pin , Chen Yu-Tse , Tam Ka-Wai , Lin I-Chan , Loh El-Wui 
Published: March 2019

Purpose:
Meibomian gland dysfunction is the main cause of dry eye disease (DED) and is traditionally managed using warm compress treatment (WCT). Vectored thermal pulsation treatment (VTPT) is a novel method for treating DED.

Methods:
We conducted a systematic review and meta-analysis of randomized controlled trials that compared the efficacy of VTPT and WCT in treating DED. The primary outcome was the gland function. The secondary outcomes were the tear breakup time, Schirmer test, tear osmolarity, lipid layer thickness, Standard Patient Evaluation for Eye Dryness, and the improvement of subjective symptoms as assessed by using the Ocular Surface Disease Index. PubMed, Embase, Cochrane Library, and ClinicalTrials.gov registries were searched for studies published before July 2018.

Results:
This study consisted of 4 trials with 385 patients. Significantly greater improvement was observed in meibomian gland function [mean difference (MD): 2.19 (95% confidence interval (CI), 0.95, 3.43)], tear breakup time [MD: 1.08 (95% CI, 0.06, 2.10)], and Standard Patient Evaluation for Eye Dryness [MD: −2.76 (95% CI, −4.22, −1.30)] at 2 to 4 weeks in the VTPT group than in the WCT group. A significantly greater decrease in Ocular Surface Disease Index was observed at 2 to 4 weeks [MD: −8.61 (95% CI, −13.62, −3.61)] and 3 months [MD: −6.92 (95% CI, −11.95, −1.89)] in the VTPT group than in the WCT group.

Conclusions:
A single 12-minute VTPT was more efficacious than traditional WCT in treating DED either in objective or subjective measurements. We recommended choosing an appropriate treatment after shared decision-making.
Trauma care systems in India and China
Authors: Babhulkar Sushrut , Apte Ashutosh , Barick Devashish , Hoogervorst Paul , Tian Yun , Wang Yan 
Published: March 2019

Abstract
Neither India nor China has a formalized trauma system in place. There are many similarities between the 2 countries in terms of size, rapid economic growth, increasing number of motor vehicles, and high rates of road traffic accident (RTA) fatalities. This paper describes the current development of elements of the trauma system in China and the strategies and efforts made to improve the trauma system in India. In China, though not organized and formalized, different phases of the trauma system are present at varying levels of maturity. In India, efforts are made to implement a trauma system by mainly focusing on preventive measures and the creation of trauma designated facilities. Although progress has been made, the concept of “adequate trauma care for all” continues to remain an aspiration in many Asian countries, including India and China. Continued and concerted effort across many levels will be required to achieve this goal.
Development of trauma systems in Europe—reports from England, Germany, the Netherlands, and Spain
Authors: Chesser Tim JS , Moran Chris , Willett Keith , Bouillon Bertil , Sturm Johannes , Flohé Sascha , Ruchholtz Steffen , Dijkink Suzan , Schipper Inger B. , Rubio-Suarez Juan Carlos , Chana Francisco , de Caso Julio , Guerado Enrique 
Published: March 2019

Abstract
Major trauma systems have evolved in many European countries and have resulted in improved care in terms of mortality and morbidity. Many of the systems have similar history, with reports of either poor services, or a single disaster, driving change of policy and set up. We report on 4 European systems, looking at the background, set up and some of the results. Similar issues are identified including the importance of triage, the concentration of specialist skills which require patients to bypass hospitals, and the standardization of treatment protocols. The issues of rehabilitation and the increasing importance of measuring outcome with patient reported metrics are discussed.
Exercise Training Guidelines for Multiple Sclerosis, Stroke, and Parkinson Disease
Authors: Kim Yumi , Lai Byron , Mehta Tapan , Thirumalai Mohanraj , Padalabalanarayanan Sangeetha , Rimmer James H. , Motl Robert W. 
Published: March 2019

Abstract
The translation of knowledge from exercise training research into the clinical management of multiple sclerosis, stroke, and Parkinson disease requires evidence-based guidelines that are uniformly recognizable by healthcare practitioners and patients/clients. This article synthesized resources that reported aerobic and resistance training guidelines for people with multiple sclerosis, stroke, and Parkinson disease. Systematic searches yielded 25 eligible resources from electronic databases and Web sites or textbooks of major organizations. Data were extracted (exercise frequency, intensity, time, and type) and synthesized into three sets of recommendations. Exercise guidelines for multiple sclerosis consistently recommended 2–3 d/wk of aerobic training (10–30 mins at moderate intensity) and 2–3 d/wk of resistance training (1–3 sets between 8 and 15 repetition maximum). Exercise guidelines for stroke recommended 3–5 d/wk of aerobic training (20–40 mins at moderate intensity) and 2–3 d/wk of resistance training (1–3 sets of 8–15 repetitions between 30% and 50% 1 repetition maximum). Exercise guidelines for Parkinson disease recommended 3–5 d/wk of aerobic training (20–60 mins at moderate intensity) and 2–3 d/wk of resistance training (1–3 sets of 8–12 repetitions between 40% and 50% of 1 repetition maximum). This harmonization of exercise guidelines provides a prescriptive basis for healthcare providers, exercise professionals, and people with multiple sclerosis, stroke, and Parkinson disease regarding exercise programming.
Use of Vacuum-Assisted Wound Closure and Tissue Expansion in Revision Cranioplasty for a Large-Sized Composite Defect in a Child
Authors: Zhai Zhen , Yu Lu , Ren TianJian , Jin Xiaolei , Yang Xiaonan , Qi Zuoliang 
Published: March 2019

Abstract
Cranioplasty is generally defined as the procedure to reconstruct cranial bone defect arising from congenital or acquired process. As a surgical remedy, it can restore the function of original anatomical structure and produce a satisfactory cosmetic outcome. Although with available options for treating pediatric cranioplasty, large format (ie, >25 cm2) cranioplasty of the aborted one with a composite defect is still a challenging procedure for plastic surgeons. The authors herein present a case of child who suffered failed cranioplasty with polyetheretherketone caused by postoperative infection, leading to skin ulcer and exposure of the polyetheretherketone. The treatments of the patient are performed sequentially. After thorough debridement of the wound, vacuum-assisted wound closure and autologous split-thickness skins are successively used to cover the defect following finally adopted strategy of tissue expansion of the scalp with a 3-dimensional-printed epoxide acrylate maleic composite material to repair the large-sized cranial defect.
A Patient With Periorbital Necrotizing Fasciitis by Klebsiella pneumoniae
Authors: Park Jinhwan , Kim Seungheon , Lee Byungil , Baek Sehyun 
Published: March 2019

Abstract
Periorbital necrotizing fasciitis (NF) is a very rare disease with a mortality rate of 10% to 20%, requiring rapid diagnosis and active treatment. The most common causative organism is Group A β-hemolytic Streptococcus, and trauma, operative incisions, pre-existing ulcers, or injection sites may be predisposing factors for periorbital NF. In this study, the subject, who had a medical history of diabetes mellitus and chronic liver disease, developed periorbital NF suddenly and without any specific triggering factors, and Klebsiella pneumoniae was identified in a necrotic tissue biopsy. Klebsiella pneumoniae has not been reported as a causative organism of periorbital NF. It is believed that latent infection with K pneumoniae, which caused a brain abscess in the patient 2 years prior, caused inflammation around the periorbit by hematogenous spread. The authors were able to manage the patient successfully by performing total exenteration and reconstructing the affected site using a transverse rectus abdominis myocutaneous flap procedure.
Histopathological Effects of Bone Cement on Cartilage Tissue
Authors: Tansuker Hasan Deniz , Topkar Ilknur , Eroğlu Sinan , Öğreden Şahin , Cengiz A. Buğra , Emre Funda , Oktay Mehmet Faruk 
Published: March 2019

Introduction:
Glass ionomer bone cement is frequently applied with cartilage grafts in otology, even as a single unit.

Objective:
This experimental study was performed to investigate the histopathological effects of bone cement on cartilage tissue.

Methods:
The study was conducted between January 2018 and April 2018 and used 12 New Zealand White rabbits. The right ears of the rabbits constituted the study group, while the left ears were the controls. Ketac Cem Radiopaque (3 M Germany) was used as glass ionomer cement. Tissue samples from the rabbits were subjected to histopathological analysis to compare acute and chronic inflammation, foreign body reaction, angiogenesis, collagenesis, fibrosis, necrosis, cartilage fracture, osseous metaplasia, and loss of chondrocyte nuclei between the groups.

Results:
The rates of cartilage fracture (P = 0.044), foreign body reaction (P < 0.001), acute inflammation (P = 0.009), chronic inflammation (P = 0.002), and angiogenesis (P = 0.003) were significantly higher in the study group compared with the controls. The study group showed some degree of necrosis; no necrosis was observed in the control group, but the difference was not statistically significant (P = 0.101). There were no significant differences in fibrosis, collagenesis, osseous metaplasia, or loss of chondrocyte nuclei between the groups.

Conclusions:
This study showed that application of bone cement can cause acute and chronic inflammation, foreign body reactions, angiogenesis, and cartilage fractures. Further studies are needed to determine the long-term effects of bone cement on cartilage.
Pseudotumoral demyelinating lesions: diagnostic approach and long-term outcome
Authors: Hardy Todd A. 
Published: March 2019

Purpose of review
To review the clinical findings, differential diagnosis, treatment and outcome of pseudotumoral demyelinating lesions including tumefactive demyelination and Baló's concentric sclerosis.

Recent findings
MRI findings, such as dynamic restricted diffusion changes at the edge of pseudotumoral lesions help to discriminate atypical demyelination from key differential diagnoses, and together with histopathological data, indicate that tissue hypoxia may be important aetiologically. CT-PET imaging can help to distinguish pseudotumoral lesions from high-grade tumours. Although most patients with pseudotumoral lesions have or later develop multiple sclerosis, a proportion will experience a monophasic course or be diagnosed with neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination or acute disseminated encephalomyelitis (ADEM). Many patients with pseudotumoral demyelinating lesions have a favourable prognosis.

Summary
Not all patients with pseudotumoral lesions require a brain biopsy but close follow-up of biopsied and nonbiopsied lesions is indicated once a diagnosis is established. Testing for AQP4-IgG and MOG-IgG is recommended when a pseudotumoral demyelinating lesion is identified. In the absence of large, prospective studies, it seems reasonable that patients with pseudotumoral lesions who fulfil multiple sclerosis diagnostic criteria are treated with multiple sclerosis therapies.
Serotonin Syndrome After an Alcohol Intake in a Patient Treated With Escitalopram and Clomipramine
Authors: Suzuki Akihito , Otani Koichi 
Published: March 2019

Background
We report on the serotonin syndrome after an alcohol intake in a patient with major depressive disorder treated with escitalopram and clomipramine.

Case
A 26-year-old male patient with major depressive disorder had been stable on the treatment with escitalopram (20 mg/d) and clomipramine (50 mg/d) for 4 months. He had rarely taken alcohol, especially never with medication. One night after taking these drugs with a can of beer, he developed agitation, disorientation, myoclonus, hyperreflexia, tremor, tachycardia, diaphoresis, and hypertension, fulfilling the criteria for the serotonin syndrome. It was considered that the serotonin syndrome in the present case might be induced by alcohol's pharmacodynamic interaction with escitalopram and clomipramine leading to decreased clearance of extracellular serotonin in the brain and/or pharmacokinetic interaction with clomipramine leading to increased clomipramine levels.

Conclusions
The present case report suggests that there may be an interaction between alcohol and antidepressants resulting in the serotonin syndrome, and clinicians should be aware of this possibility.
The gut microbiota regulates mouse biliary regenerative responses
Authors: Liu Wenli , Yan Chao , Zhang Bo , Chen Renjin , Yu Qian , Li Xiangyang , Zhang Yuzhao , Hua Hui , Wei Yanxia , Kou Yanbo , Liu Zhuanzhuan , Tang Renxian , Zheng Kuiyang , Wang Yugang 
Published: March 2019

AbstractInjury to the biliary epithelium triggers cholangiopathies. However, factors involved in regulating the pathogenesis remains incompletely understood. Here, we report that the gut microbiota is important in regulating hepatobiliary fibroproliferative regenerative process. In helminth Clonorchis sinensis-induced bile duct injury model, wild-type mice showed more extensive peribiliary fibroproliferative responses than non-littermate IL-33-deficient mice. However, these reactions could be attenuated by co-housing of the animals together. In the meantime, the relatively fibroproliferative-resistant IL-33-deficient mice could become fibroproliferative-responsive especially in large intrahepatic bile duct by antibiotics treatment. Furthermore, microbiota-derived metabolite butyrate was able to inhibit biliary organoid expansion in vitro and temper 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced biliary fibrosis in vivo. Together, our data implies a potential way of management of hepatobiliary diseases by modulating gut microbiota.
The quail as an avian model system: its genome provides insights into social behaviour, seasonal biology and infectious disease response
Authors: Morris Katrina M , Hindle Matthew M , Boitard Simon , Burt David W , Danner Angela F , Eory Lel , Forrest Heather L , Gourichon David , Gros Jerome , Hillier LaDeana , Jaffredo Thierry , Khoury Hanane , Lansford Rusty , Leterrier Christine , Loudon Andrew , Mason Andrew S , Meddle Simone L , Minvielle Francis , Minx Patrick , Pitel Frédérique , Seiler J Patrick , Shimmura Tsuyoshi , Tomlinson Chad , Vignal Alain , Webster Robert G , Yoshimura Takashi , Warren Wesley C , Smith Jacqueline 
Published: March 2019

ABSTRACTThe Japanese quail (Coturnix japonica) is a popular domestic poultry species and an increasingly significant model species in avian developmental, behavioural and disease research. We have produced a high-quality quail genome sequence, spanning 0.93 Gb assigned to 33 chromosomes. In terms of contiguity, assembly statistics, gene content and chromosomal organization, the quail genome shows high similarity to the chicken genome. We demonstrate the utility of this genome through three diverse applications. First, we identify selection signatures and candidate genes associated with social behaviour in the quail genome, an important agricultural and domestication trait. Second, we investigate the effects and interaction of photoperiod and temperature on the transcriptome of the quail medial basal hypothalamus, revealing key mechanisms of photoperiodism. Finally, we investigate the response of quail to H5N1 influenza infection. In quail lung, many critical immune genes and pathways were downregulated, and this may be key to the susceptibility of quail to H5N1. This genome will facilitate further research into diverse research questions using the quail as a model avian species.
Nanopore sequencing of the pharmacogene CYP2D6 allows simultaneous haplotyping and detection of duplications
Authors: Liau Yusmiati , Maggo Simran , Miller Allison L. , Pearson John F. , Kennedy Martin A. , Cree Simone L. 
Published: March 2019

AbstractBackgroundThe accurate genotyping of CYP2D6 is hindered by the very polymorphic nature of the gene, high homology with its pseudogene CYP2D7, and the occurrence of structural variations. Long read sequencing offers the promise of overcoming some of these challenges, along with the advantage of straightforward variant phasing. We have established methods for sequencing and analysis of DNA amplicons containing the whole CYP2D6 gene, using the GridION nanopore sequencer.Materials and methodsSeven reference and 25 clinical samples covering various haplotypes including gene duplication were barcoded and sequenced over two sequencing runs. Sequenced raw reads were analyzed using a pipeline of bioinformatics tools including two mapping tools and two variant calling tools.ResultsUsing minimap2 and nanopolish (mapping and variant calling tools respectively) resulted in the most accurate variant detection. Haplotypes of 52 alleles could be matched accurately to known alleles or subvariants, while the remaining 12 alleles being assigned as novel star (*) allele of novel subvariants of known alleles in the PharmVar CYP2D6 haplotype database. Allele duplication could be detected by analyzing the allelic balance between the sample haplotypes.ConclusionNanopore sequencing of CYP2D6 offers a high throughput method for genotyping, accurate haplotyping, and detection of new variants and duplicated alleles.
Exploring consumers’ purchase intention in social commerce
Authors: Liu Chao , Bao Zheshi , Zheng Chuiyong 
Published: March 2019

Purpose
The purpose of this paper is to explore motivations that drive consumers’ purchase intention in social commerce, and then examine whether social presence can work as a moderator in this process.

Design/methodology/approach
A research model was developed based on stimulus-organism-response model by integrating trust, argument quality, social presence and purchase intention. Using the data collected from 288 valid online questionnaires, the proposed model was empirically assessed by partial least square (PLS) SEM.

Findings
The results show that trust toward social commerce site and trust toward site members are determinants of purchase intention, and the later one can be triggered by the argument quality of consumer-generated contents (perceived informativeness and perceived persuasiveness). Besides, consumers’ social presence has a moderating effect on the relationship between trust toward site members and purchase intention.

Originality/value
This study indicates a new mechanism of trust based on the context of social commerce. The findings will contribute to social commerce literature by offering a well proven conceptual model that facilitates the understanding of consumers’ purchase decision-making processes.
Social media and Chinese consumers’ environmentally sustainable apparel purchase intentions
Authors: Zhao Li , Lee Stacy H. , Copeland Lauren Reiter 
Published: March 2019

Purpose
Social media and sustainability are changing Chinese consumers’ consumption behavior in notable ways. Few apparel industry sustainability efforts are enforced or well known in China. As China operates its own social media sites, it is necessary to study Chinese social media, rather than Western types, in order to understand its influence on Chinese consumer behavior with regard to sustainability. By extending the theory of reasoned action (TRA) and the prototype willingness model, the purpose of this paper is to investigate how Chinese consumers were taught their environmentally sustainable apparel (ESA) consumption behavior through social media, and also how the influence of peers affected their purchase intentions.

Design/methodology/approach
A total of 238 survey responses were collected and analyzed from a Chinese research firm in 2016. In accord with the study objectives, an exploratory factor analysis was first conducted, and then a two-step analysis of a structural equation model was employed for hypothesis testing. To test the significance of hypothesized mediated effects, a bootstrap procedure with 2,000 bootstrap samples from the original data was used to compute bias-corrected 95% CI for indirect effects. Moreover, hierarchical regressions were demonstrated to verify the unique contribution of social media influence.

Findings
The study findings support the previous literature that indicated positive attitudes toward environmentally sustainable purchasing behavior increased as Chinese consumers learned about social and environmental issues. Also, results of the analysis revealed that Chinese consumers’ engagement with social media and their peers were important social influences that were directly tied to increasing sustainable apparel purchase intentions.

Originality/value
By extending two grand theories of the prototype willingness model theory and the TRA, this study underlines a novel link between the influence of social media and ESA purchase intentions among Chinese consumers. Results are valuable in a global context as it is one of only a few studies to explore Chinese consumers’ purchase intentions of ESA through an exclusive social media platform – WeChat – in China.
Physicochemical properties, bioactive components, antioxidant and antimicrobial potentials of some selected honeys from different provinces of Turkey
Authors: Erturk Ömer , Kalın Sefine , Ayvaz Melek Çol 
Published: March 2019

PurposeThe purpose of this paper is to characterize monofloral and heterofloral honey samples (chestnut, lavandula, acacia and sunflower) from different regions of Turkey according to their physicochemical (moisture content, acidity, ash, sucrose, reducing sugar and hydroxymethylfurfural content) and biochemical properties to compare regional and species differences that are thought to contain different types of plant sources.Design/methodology/approachPhysicochemical investigations were performed according to AOAC methods. Mineral analysis and volatile analysis were performed by using atomic absorption spectrometry and GC–MS, respectively. Antimicrobial activities of honey samples were evaluated based on disc diffusion method and minimum inhibition concentration (MIC) values. The assays followed to determine total phenolic content and antioxidative and activities are spectrophotometric methods.FindingsThe obtained values of physicochemical parameters are among the values that can be accepted according to legal regulations. The most abundant mineral was potassium, which made up 81 per cent of the total mineral content, ranging between 165.7 and 301.6 mg/kg. A total of 87 different volatile components, some of which are highlighted in the literature to have antimicrobial and antioxidant effects, were detected. The maximum phenolic content, antioxidant activity against DPPH radical and ferric reducing ability were detected in the chestnut honeys. All tested honeys showed antimicrobial activity with MIC values between 6.25 and 50 µg/mL.Originality/valueThe present study has the feature of being a large study in terms of the region from where honey samples were selected and choice of analysis. The values obtained from physicochemical parameters reveal that the honeys from related region can be consumed with confidence. The biological properties found in honeys make them products of high added value and excellent quality.