bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of FCC-NMRD relaxometry for early detection and characterization of ex-vivo murine breast cancer
Authors: Di Gregorio Enza , Ferrauto Giuseppe , Lanzardo Stefania , Gianolio Eliana , Aime Silvio 
Published: March 2019

AbstractBreast Cancer is the most diffuse cancer among women and the treatment outcome is largely determined by its early detection. MRI at fixed magnetic field is already widely used for cancer detection. Herein it is shown that the acquisition of proton T1 at different magnetic fields adds further advantages. In fact, Fast Field Cycling Nuclear Magnetic Resonance Dispersion (FFC-NMRD) profiles have been shown to act as a high –sensitivity tool for cancer detection and staging in ex vivo murine breast tissues collected from Balb/NeuT mice. From NMRD profiles it was possible to extract two new cancer biomarkers, namely: (i) the appearance of 14N-quadrupolar peaks (QPs) reporting on tumor onset and (ii) the slope of the NMRD profile reporting on the progression of the tumor. By this approach it was possible to detect the presence of tumor in transgenic NeuT mice at a very early stage (5–7 weeks), when the disease is not yet detectable by using conventional high field (7 T) MRI and only minimal abnormalities are present in histological assays. These results show that, NMRD profiles may represent a useful tool for early breast cancer detection and for getting more insight into an accurate tumor phenotyping, highlighting changes in composition of the mammary gland tissue (lipids/proteins/water) occurring during the development of the neoplasia.
Development of Tungsten Oxide Nanoparticle Modified Carbon Fibre Cloth as Flexible pH Sensor
Authors: Jamal Mamun , Razeeb Kafil M. , Shao Han , Islam Jahidul , Akhter Irani , Furukawa Hidemitsu , Khosla Ajit 
Published: March 2019

AbstractA reagent-less pH sensor based on disposable and low cost carbon fibre cloth (CFC) is demonstrated for the first time, where tungsten oxide nanoparticles were grown directly onto the CFC substrate. For comparison purpose, tungsten oxide nanoparticle modified glassy carbon electrode (GCE) was also fabricated as a pH sensor, where hydrothermally synthesized tungsten oxide nanoparticles were drop casted onto the GCE surface. The corresponding equilibrium potential using tungsten oxide/CFC as a pH sensor was measured using open circuit potential (OCP), and was found to be linear over the pH range of 3–10, with a sensitivity of 41.38 mVpH−1, and response time of 150 s. In the case of tungsten oxide/GCE as a pH sensor, square wave voltammetry (SWV) was used to measure the shifts in peak potential and was found to be linear with a pH range of 3–11, and a sensitivity of 60 mVpH−1 with a potential drift of 2.4–5.0% after 3 hour of continuous use. The advantages of tungsten oxide/CFC and tungsten oxide/GCE as pH sensing electrode have been directly compared with the commercial glass probe based electrode, and validated in real un-buffered samples. Thereby, tungsten oxide nanoparticles with good sensitivity and long term stability could be potentially implemented as a low cost and robust pH sensor in numerous applications for the Internet of Things (IoT).
Silencing of maternal hepatic glucocorticoid receptor is essential for normal fetal development in mice
Authors: Quinn Matthew A. , McCalla Amy , He Bo , Xu Xiaojiang , Cidlowski John A. 
Published: March 2019

AbstractExcessive or chronic stress can lead to a variety of diseases due to aberrant activation of the glucocorticoid receptor (GR), a ligand activated transcription factor. Pregnancy represents a particular window of sensitivity in which excessive stress can have adverse outcomes, particularly on the developing fetus. Here we show maternal hepatic stress hormone responsiveness is diminished via epigenetic silencing of the glucocorticoid receptor during pregnancy. Provocatively, reinstallation of GR to hepatocytes during pregnancy by adeno-associated viral transduction dysregulates genes involved in proliferation, resulting in impaired pregnancy-induced hepatomegaly. Disruption of the maternal hepatic adaptation to pregnancy results in in utero growth restriction (IUGR). These data demonstrate pregnancy antagonizes the liver-specific effects of stress hormone signaling in the maternal compartment to ultimately support the healthy development of embryos.
ADS-J1 disaggregates semen-derived amyloid fibrils
Authors: Li Jinqing , Yang Zichao , Liu Han , Qiu Mengjie , Zhang Tingting , Li Wenjuan , Li Zhaofeng , Qi Tao , Qiu Yurong , Li Lin , Zhou Xuefeng , Liu Shuwen , Tan Suiyi 
Published: March 2019

Abstract
Semen-derived amyloid fibrils, comprising SEVI (semen-derived enhancer of viral infection) fibrils and SEM1 fibrils, could remarkably enhance HIV-1 sexual transmission and thus are potential targets for the development of an effective microbicide. Previously, we found that ADS-J1, apart from being an HIV-1 entry inhibitor, could also potently inhibit seminal amyloid fibrillization and block fibril-mediated enhancement of viral infection. However, the remodeling effects of ADS-J1 on mature seminal fibrils were unexplored. Herein, we investigated the capacity of ADS-J1 to disassemble seminal fibrils and the potential mode of action by applying several biophysical and biochemical measurements, combined with molecular dynamic (MD) simulations. We found that ADS-J1 effectively remodeled SEVI, SEM186–107 fibrils and endogenous seminal fibrils. Unlike epigallocatechin gallate (EGCG), a universal amyloid fibril breaker, ADS-J1 disaggregated SEVI fibrils into monomeric peptides, which was independent of oxidation reaction. MD simulations revealed that ADS-J1 displayed strong binding potency to the full-length PAP248–286 via electrostatic interactions, hydrophobic interactions and hydrogen bonds. ADS-J1 might initially bind to the fibrillar surface and then occupy the amyloid core, which eventually lead to fibril disassembly. Furthermore, the binding of ADS-J1 with PAP248–286 might induce conformational changes of PAP248–286. Disassembled PAP248–286 might not be favorable to re-aggregate into fibrils. ADS-J1 also exerts abilities to remodel a panel of amyloid fibrils, including Aβ1–42, hIAPP1–37 and EP2 fibrils. ADS-J1 displays promising potential to be a combination microbicide and an effective lead-product to treat amyloidogenic diseases.
Plant glutathione biosynthesis revisited: redox-mediated activation of glutamylcysteine ligase does not require homo-dimerization
Authors: Yang Yingxue , Lenherr Esther D. , Gromes Roland , Wang Shanshan , Wirtz Markus , Hell Rüdiger , Peskan-Berghöfer Tanja , Scheffzek Klaus , Rausch Thomas 
Published: March 2019

Abstract
Plant γ-glutamylcysteine ligase (GCL), catalyzing the first and tightly regulated step of glutathione (GSH) biosynthesis, is redox-activated via formation of an intramolecular disulfide bond. In vitro, redox-activation of recombinant GCL protein causes formation of homo-dimers. Here, we have investigated whether dimerization occurs in vivo and if so whether it contributes to redox-activation. FPLC analysis indicated that recombinant redox-activated WT (wild type) AtGCL dissociates into monomers at concentrations below 10−6 M, i.e. below the endogenous AtGCL concentration in plastids, which was estimated to be in the micromolar range. Thus, dimerization of redox-activated GCL is expected to occur in vivo. To determine the possible impact of dimerization on redox-activation, AtGCL mutants were generated in which salt bridges or hydrophobic interactions at the dimer interface were interrupted. WT AtGCL and mutant proteins were analyzed by non-reducing SDS–PAGE to address their redox state and probed by FPLC for dimerization status. Furthermore, their substrate kinetics (KM, Vmax) were compared. The results indicate that dimer formation is not required for redox-mediated enzyme activation. Also, crystal structure analysis confirmed that dimer formation does not affect binding of GSH as competitive inhibitor. Whether dimerization affects other enzyme properties, e.g. GCL stability in vivo, remains to be investigated.
The association of toll-like receptor 4 gene polymorphisms with primary open angle glaucoma susceptibility: a meta-analysis
Authors: Chaiwiang Narttaya , Poyomtip Teera 
Published: March 2019

Abstract
Primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) cause irreversible blindness while current medications cannot completely inhibit disease progression. An understanding of immunopathogenesis is thus a keystone to develop novel drug targets and genetic markers are still required for early diagnosis. Toll-like receptor 4 (TLR4) is an essential player in inflammation in various diseases. However, the TLR4 polymorphisms have not been completely elucidated in both types of glaucoma. The aim of the present study was to identify the association between TLR4 polymorphism and glaucoma (POAG and NTG) via the use of a comprehensive review and meta-analysis. The relevant studies were collected from PubMed, Excerpta Medica Database (EMBASE), and Web of Science to identify eight included articles, assessed for quality by a modified Newcastle-Ottawa Scale (NOS) for gene association study. A meta-analysis was applied to calculate the pooled odds-ratio and 95% confidence intervals (CIs) to evaluate the association between TLR4 polymorphism and glaucoma. The results revealed that TLR4 rs1927911 A/G, rs12377632 C/T, and rs2149356 G/T significantly decrease the risk of POAG and NTG in allele contrast models 0.71-, 0.71-, and 0.67-fold, respectively. Moreover, rs4986790 A/G and rs4986791 C/T showed a stringent association with POAG in allele contrast, heterozygous, recessive, and overdominant models. In conclusion, this meta-analysis represented a significant correlation between TLR4 polymorphisms and both types of glaucoma suggesting that TLR4 might be involved in the pathogenesis of glaucoma and may be applied as a genetic marker for disease screening.
Simultaneous adsorption of Hg2+, Cd2+ and Cu2+ ions from aqueous solution with mesoporous silica/DZ and conditions optimise with experimental design: kinetic and isothermal studies
Authors: Nazerdeylami Samaneh , Zare‐Dorabei Rouholah 
Published: March 2019

This study used dithizon (DZ) and mesoporous as a sorbent for simultaneous removal of heavy metal (mercury, cadmium and copper) ions from aqueous solution and real samples. Santa Barbara Amorphous synthesised and characterised by X‐ray diffraction, Fourier‐transform infrared spectroscopy and Brunauer–Emmett–Teller. Heavy metal ions measured by atomic absorption spectrometry and inductively coupled plasma optical emission spectrometry. Optimised conditions such as pH, removal time, sorbent dosage and concentration analyte with central composite design and obtained 5, 20 min, 20 mg and 25 ppm, respectively. The equilibrium data were fitted to isotherm models such as Langmuir, Freundlich and Tempkin and the results revealed the suitability of the Langmuir model. The maximum adsorption capacities for Hg2+, Cd2+ and Cu2+ ions achieved 25.04, 30.3 and 31.79 mg/g, respectively. Kinetics data fitting to pseudo‐first order, pseudo‐second‐order and Elovich models confirmed the applicability of pseudo‐second‐order kinetic model for the description of the mechanism and adsorption rate. This sorbent could regenerate easily with ethylenediamminetetraacetate solution.
Morphology-assisted galaxy mass-to-light predictions using deep learning
Authors: Dobbels Wouter , Krier Serge , Pirson Stephan , Viaene Sébastien , De Geyter Gert , Salim Samir , Baes Maarten 
Published: March 2019

Context. One of the most important properties of a galaxy is the total stellar mass, or equivalently the stellar mass-to-light ratio (M/L). It is not directly observable, but can be estimated from stellar population synthesis. Currently, a galaxy’s M/L is typically estimated from global fluxes. For example, a single global g − i colour correlates well with the stellar M/L. Spectral energy distribution (SED) fitting can make use of all available fluxes and their errors to make a Bayesian estimate of the M/L.
Aims. We want to investigate the possibility of using morphology information to assist predictions of M/L. Our first goal is to develop and train a method that only requires a g-band image and redshift as input. This will allows us to study the correlation between M/L and morphology. Next, we can also include the i-band flux, and determine if morphology provides additional constraints compared to a method that only uses g- and i-band fluxes.
Methods. We used a machine learning pipeline that can be split in two steps. First, we detected morphology features with a convolutional neural network. These are then combined with redshift, pixel size and g-band luminosity features in a gradient boosting machine. Our training target was the M/L acquired from the GALEX-SDSS-WISE Legacy Catalog, which uses global SED fitting and contains galaxies with z ∼ 0.1.
Results. Morphology is a useful attribute when no colour information is available, but can not outperform colour methods on its own. When we combine the morphology features with global g- and i-band luminosities, we find an improved estimate compared to a model which does not make use of morphology.
Conclusions. While our method was trained to reproduce global SED fitted M/L, galaxy morphology gives us an important additional constraint when using one or two bands. Our framework can be extended to other problems to make use of morphological information.
Collimated radiation in SS 433
Authors: Waisberg Idel , Dexter Jason , Olivier-Petrucci Pierre , Dubus Guillaume , Perraut Karine 
Published: March 2019

Context. The microquasar SS 433 is well known for its precessing, relativistic, and highly collimated baryonic jets, which manifest in its optical spectrum as pairs of hydrogen and helium emission lines moving with large Doppler shifts. Depending on their heating mechanism, the optical jet bullets may serve as a probe of the collimated radiation coming from the inner region close to the compact object, and which is not directly visible to observers on Earth.
Aims. We aim to better understand the baryonic jet phenomenon in SS 433, in particular the properties of the optical bullets and their interaction with the ionizing collimated radiation.
Methods. The optical interferometer VLTI/GRAVITY has allowed us to spatially resolve the optical jets in SS 433 for the first time. We present here the second such observation taken over three nights in July 2017. In addition, we used the X-shooter spectrograph at VLT to study the optical bullets in SS 433 in detail. Over the full wavelength range 0.3−2.5 μm, we identified up to twenty pairs of jet lines observed simultaneously, which we modeled with the spectral synthesis code Cloudy.
Results. GRAVITY reveals elongated exponential-like radial spatial profiles for the optical jets on scales ≲1−10 mas, suggestive of a heating mechanism acting throughout a long portion of the jet and naturally explained by photoionization by the collimated radiation. We also spatially resolve the movement of the optical bullets for the first time, detecting more extended jet components corresponding to previous ejections. Cloudy photoionization models can explain the spatial intensity profiles measured with GRAVITY and the emission line ratios from X-shooter, and constrain the properties of the optical bullets and the ionizing radiation. We find that the latter must peak in the UV with an isotropic luminosity (as inferred by a face-on observer) ∼1041 erg s−1. Provided that the X-ray spectral energy distribution is sufficiently hard, the collimated X-ray luminosity could still be high enough so that the face-on observer would see SS 433 as ultraluminous X-ray source and it would still be compatible with the H/He/He+ ionization balance of the optical bullets. The kinetic power in the optical jets is constrained to 2−20 × 1038 erg s−1, and the extinction in the optical jets to AV = 6.7 ± 0.1. We suggest there may be substantial AV ≳ 1 and structured circumstellar extinction in SS 433, likely arising from dust formed in equatorial outflows.
La pente individualiste
Authors: Bourcier Gérard 
Published: March 2019

Depuis quelques dizaines d’années, de nombreux auteurs, qu’ils soient sociologues (Gauchet, Ehrenberg) ou cliniciens (Lebrun, Melman, Jeammet) - ont souligné les liens de cause à effet qui semblent exister entre la configuration du lien social telle qu’elle se manifeste à un moment donné de l’histoire (ancien régime, révolution industrielle, etc.) et la prévalence de certains types de personnalité et également de certaines manifestations psychopathologiques. C’est en ce sens qu’Ehrenberg, soulignant comme de nombreux auteurs la pente individualiste contemporaine, parle de l’effacement progressif de la névrose au profit de la dépression « à mesure que le continent du permis a reculé au profit du possible ». L’auteur s’efforce par ailleurs de mettre en perspective l’évolution contemporaine du lien social avec les tendances thérapeutiques actuelles.
Actual Problems of the Russian Economy
Authors: Moiseev V.V. , Kramskoy S.I. , Karelina E.A. , Karelina M.Yu. 
Published: March 2019

The urgency of researching the problems of the Russian economy is beyond doubt. It is determined by the scale and complexity of the tasks set by President V. Putin in 7the May 2018 decree.
The purpose of the study is to study the current problems of the Russian economy and, on this basis, offer recommendations for their elimination in order to achieve the indicators indicated by the head of state and above all enter the TOP-5 largest economies of the world.
The main objectives of the study were: 1. To identify the main problems of the Russian economy. 2. To analyze the current shortcomings policy. 3. To show the conditions under which the economy can develop at a pace. When studying the main issues of the topic, the authors use the following methods: dialectic, system-functional, economic-statistical, and formal-logical methods; the method of comparative analysis was used by the authors for comparison with the economies of other countries, for example, with the economy of China.
In this article, the authors attempted to analyze the main current problems of the Russian economy in order to show which “baggage” should be eliminated in the near future, which priority tasks should be solved in order to make a planned breakthrough in socio-economic development and get into the TOP-5 largest economies in the world.
The Main Modernization Directions of the Industrial Complex
Authors: Belanova N.N. , Kornilova A.D. , Mantulenko V.V. , Mantulenko A.V. 
Published: March 2019

The functioning of enterprises in the conditions of economic uncertainty and high risks associated with it, dependence on external economic conjuncture, low competitiveness of domestic goods and services of Russia give determine a range of problems that can be solved only through modernization reforms in industry. They are determined by the formation of a competitive type of industrial production in Russia and high-tech industries that are able to generate high technology and modernize the sectoral system of national reproduction. Modernization of the Russian industry is based on internal growth factors using modern technologies and business methods with a gradual increase of the innovation potential.
The purpose of the study is to identify the main directions of modernization for the formation of a modern competitive industry as the basis for ensuring economic growth and improving the quality of life of the population. To achieve this goal, the authors used dialectical, system-functional, economic-statistical, and formal-logical methods.
In this contribution, the authors summarized the main directions of the implementation of industrial policy, presented statistical data on the creation of industrial parks. To strengthen the industrial potential of the Russian economy, it is necessary to provide conditions for the development of modern production, increasing production and energy efficiency, and increasing investment in fixed assets. The authors developed measures for the modernization of the industrial complex and predicted results of this program. Among key activities there are the development of affordable investment and innovation infrastructure, the creation of industrial parks and the development of the institutional environment.
Elevated Circulating Levels of Motilin are Associated with Diabetes in Individuals after Acute Pancreatitis
Authors: Gold-Smith Fuchsia D. , Singh Ruma G. , Petrov Maxim S. 
Published: March 2019

Abstract
Aim The study aimed to investigate the associations between glycaemic control after acute pancreatitis and gastrointestinal motility, using plasma motilin concentration and gastroparesis cardinal symptom index score as proxies.
Methods This cross-sectional study recruited a total of 93 individuals after acute pancreatitis. Gastroparesis cardinal index scores, demographic and anthropometric factors, as well as pancreatitis-related factors were analysed. Fasting venous blood was collected to measure motilin, glycated haemoglobin, and fasting blood glucose. Linear regression analyses were conducted to investigate the associations between glycaemic control and gastrointestinal motility in unadjusted and adjusted models.
Results Motilin was significantly higher in individuals with diabetes across all adjusted models, with the highest ß-coefficient (95% confidence interval) of 588.89 (138.50, 1039.28); P=0.010. Fasting blood glucose was significantly associated with motilin across all models, with the highest ß-coefficient (95% confidence interval) of 156.30 (55.49, 257.10); P=0.002. Glycated haemoglobin was significantly associated with motilin in one adjusted model with ß-coefficient (95% confidence interval) of 18.78 (1.53, 36.02); P=0.033. Gastroparesis cardinal symptom index was not significantly associated with any measure of glycaemic control.
Conclusions Diabetes in individuals after acute pancreatitis appears to be characterised by elevated plasma motilin but not gastroparesis cardinal symptom index. The role of motilin in this setting warrants further investigations.