bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcatheter closure of ventricular septal defect with Occlutech Duct Occluder
Authors: Atik-Ugan Sezen , Saltik Irfan Levent 
Published: March 2018

AbstractPatent ductus arteriosus occluders are used for transcatheter closure of ventricular septal defects, as well as for closure of patent ductus arteriosus. The Occlutech Duct Occluder is a newly introduced device for transcatheter closure of patent ductus arteriosus. Here, we present a case in which the Occlutech Duct Occluder was successfully used on a patient for the closure of a perimembraneous ventricular septal defect.
Rare presentation ofCandida albicans: infective endocarditis and a pulmonary coin lesion
Authors: Öner Taliha , Korun Oktay , Çelebi Ahmet 
Published: March 2018

AbstractWe present a case of a rare association of infective endocarditis and a coin lesion in the lung caused byCandida albicans. The lesion disappeared after 6 weeks of treatment with 5 mg/kg/day amphotericin B.
Light propagation in the Solar System for astrometry on sub-micro-arcsecond level
Authors: Zschocke Sven 
Published: March 2018

AbstractWe report on recent advancement in the theory of light propagation in the Solar System aiming at sub-micro-arcsecond level of accuracy:
(1)A solution for the light ray in 1.5PN approximation has been obtained in the field of N arbitrarily moving bodies of arbitrary shape, inner structure, oscillations, and rotational motion.(2)A solution for the light ray in 2PN approximation has been obtained in the field of one arbitrarily moving pointlike body.
Clarification of the formation process of the super massive black hole by Infrared astrometric satellite, Small-JASMINE
Authors: Yano Taihei ,   JASMINE-WG
Published: March 2018

AbstractSmall-JASMINE (hearafter SJ), infrared astrometric satellite, will measure the positions and the proper motions which are located around the Galactic center, by operating at near infrared wave-lengths. SJ will clarify the formation process of the super massive black hole (hearafter SMBH) at the Galactic center. In particular, SJ will determine whether the SMBH was formed by a sequential merging of multiple black holes. The clarification of this formation process of the SMBH will contribute to a better understanding of merging process of satellite galaxies into the Galaxy, which is suggested by the standard galaxy formation scenario. A numerical simulation (Tanikawa and Umemura, 2014) suggests that if the SMBH was formed by the merging process, then the dynamical friction caused by the black holes have influenced the phase space distribution of stars. The phase space distribution measured by SJ will make it possible to determine the occurrences of the merging process.
Variable stars in the Gaia era: Mira, RR Lyrae, δ and Type-II Cepheids
Authors: Groenewegen Martin A. T. 
Published: March 2018

AbstractClassical variables like RR Lyrae, classical and Type-II Cepheids and Mira variables all follow period-luminosity relations that make them interesting as distance indicators. Especially the RR Lyrae and δ Cepheids are crucial in establishing the distance scale in the Universe, and all classes of variables can be used as tracers of galactic structure. I will present an overview of recent period-luminosity relations and review the work that has been done using the Gaia DR1 data so far, and discuss possibilities for the future.
The Baade-Wesselink p-factor of Cepheids in the Gaia area
Authors: Nardetto Nicolas 
Published: March 2018

AbstractWith the next Gaia release (expected in April 2018), the distance of about 300 Galactic Cepheids will be derived with a precision of better than 3%. These distances will be used first to constrain the Cepheid period-luminosity relation, but they will also bring strong constrains on the physics of Cepheids, through the projection factor, a physical quantity used in the inverse Baade-Wesselink (BW) method.
Double, triple and quadruple-line spectroscopic binary candidates within the Gaia-ESO Survey
Authors: Merle Thibault , Van Eck Sophie , Jorissen Alain , Van der Swaelmen Mathieu , Traven Gregor , Zwitter Tomaz 
Published: March 2018

AbstractThe Gaia-ESO Survey (GES, Gilmore et al. 2012) provides a unique opportunity to detect spectroscopically multiplicity among different populations of the Galaxy using the cross-correlation functions (CCFs). We present here the GES internal Data Release 4 (iDR4) results of the detection of double, triple and quadruple-line spectroscopic binary candidates (SBs) and discuss some peculiar systems.
Magellanic Clouds Proper Motion and Rotation with Gaia DR1
Authors: Sahlmann J. , van der Marel R. 
Published: March 2018

AbstractWe used the Gaia data release 1 to study the proper motion fields of the Large and Small Magellanic Clouds (LMC, SMC) on the basis of the Tycho-Gaia Astrometric Solution (van der Marel & Sahlmann 2016). The Gaia LMC and SMC proper motions have similar accuracy and agree to within the uncertainties with existing HST proper motion measurements. Since Gaia probes the young stellar population and uses different methods with different systematics, this provides an external validation of both data sets and their underlying approaches.
Confronting the Gaia and NLTE spectroscopic parallaxes for the FGK stars
Authors: Sitnova Tatyana , Mashonkina Lyudmila , Pakhomov Yury 
Published: March 2018

AbstractThe understanding of the chemical evolution of the Galaxy relies on the stellar chemical composition. Accurate atmospheric parameters is a prerequisite of determination of accurate chemical abundances. For late type stars with known distance, surface gravity (log g) can be calculated from well-known relation between stellar mass, Teff, and absolute bolometric magnitude. This method weakly depends on model atmospheres, and provides reliable log g. However, accurate distances are available for limited number of stars. Another way to determine log g for cool stars is based on ionisation equilibrium, i.e. consistent abundances from lines of neutral and ionised species. In this study we determine atmospheric parameters moving step-by-step from well-studied nearby dwarfs to ultra-metal poor (UMP) giants. In each sample, we select stars with the most reliable Teff based on photometry and the distance-based log g, and compare with spectroscopic gravity calculated taking into account deviations from local thermodinamic equilibrium (LTE). After that, we apply spectroscopic method of log g determination to other stars of the sample with unknown distances.
The relation between velocity dispersions and chemical abundances in RAVE giants
Authors: Smiljanic Rodolfo , de Souza Rafael Silva 
Published: March 2018

AbstractWe developed a Bayesian framework to determine in a robust way the relation between velocity dispersions and chemical abundances in a sample of stars. Our modelling takes into account the uncertainties in the chemical and kinematic properties. We make use of RAVE DR5 radial velocities and abundances together with Gaia DR1 proper motions and parallaxes (when possible, otherwise UCAC4 data is used). We found that, in general, the velocity dispersions increase with decreasing [Fe/H] and increasing [Mg/Fe]. A possible decrease in velocity dispersion for stars with high [Mg/Fe] is a property of a negligible fraction of stars and hardly a robust result. At low [Fe/H] and high [Mg/Fe] the sample is incomplete, affected by biases, and likely not representative of the underlying stellar population.
Calibration and characterisation of the Gaia Red Clump
Authors: Ruiz-Dern L. , Babusiaux C. , Arenou F. , Danielski C. , Turon C. , Sartoretti P. 
Published: March 2018

AbstractWe present new empirical Colour-Colour and Effective Temperature-Colour Gaia Red Clump calibrations. The selected sample takes into account high photometric quality, good spectrometric metallicity, homogeneous effective temperatures and low interstellar extinctions. From those calibrations we developed a method to derive the absolute magnitude, temperature and extinction of the Gaia RC. We tested our colour and extinction estimates on stars with measured spectroscopic effective temperatures and Diffuse Interstellar Band (DIB) constraints. Within the Gaia Validation team these calibrations are also being used, together with asteroseismic constraints, to check the parallax zero-point with Red Clump stars.
The age-metallicity relation with RAVE and TGAS
Authors: Wojno Jennifer , Kordopatis Georges , Steinmetz Matthias , McMillan Paul J. ,   the RAVE collaboration
Published: March 2018

AbstractUsing RAVE data release 5 (DR5), we explore the age and chemistry of a sample of ~25,000 FGK turnoff stars in the extended solar neighbourhood (7 < R < 9 kpc), by separating our sample into two chemical disc components, and investigating the nature of the age-metallicity relation for both. Overall, we find a flat trend in [Fe/H] as a function of age for our α-low disc, and a correlation between age and metallicity for the oldest α-high stars, confirming age-metallicity trends found in more local, high-resolution studies now for a larger volume. We also find a positive gradient in [Mg/Fe] as a function of age for our oldest stars. These results have implications for models which include dynamical evolutionary processes such as radial migration.
Accurate atomic data for Galactic Surveys
Authors: Belmonte Maria Teresa , Pickering Juliet C. , Clear Christian , Liggings Florence , Thorne Anne P. 
Published: March 2018

AbstractFourier Transform spectroscopy is able to provide high accuracy atomic parameters needed by many ongoing galactic surveys. Our laboratory has carried out a study of the neutral iron spectrum over the last years to measure oscillator strengths much needed for the calculation of chemical abundances. The main aim of this contribution is to encourage further dialogue with astronomers regarding their current necessities of spectroscopic data, as this would help spectroscopists to prioritise present-day needs within the field.
The Galactic mass distribution from the LAMOST Galactic spectroscopic surveys
Authors: Huang Y. , Liu X.-W. , Yuan H.-B. , Zhang H.-W. , Xiang M.-S. , Chen B.-Q. , Wang C. 
Published: March 2018

AbstractUsing the data from the LAMOST Galactic spectroscopic surveys and some other surveys, we have started a series of work to measure the mass distribution of our Galaxy. As a result of the first-stage, we have constructed the Galactic rotation curve out to 100 kpc and the Galactic escape velocity curve between 5 and 14 kpc. From the two curves, we have built parametrized mass models for our Galaxy, respectively. Both models yield a similar result for the Milky Way's virial mass: ~ 0.9 × 1012 M⊙.
Multiply imaged quasars in the Gaia DR1
Authors: Ducourant C. , Delchambre L. , Finet F. , Galluccio L. , Krone-Martins A. , Le Campion J.F. , Mignard F. , Slezak E. , Surdej J. , Teixeira R. , Wertz O. 
Published: March 2018

AbstractBecause of to its exceptional resolving power, Gaia should detect a few thousands gravitational lensed systems. These consist in multiple images of background quasars. The estimated number of lens phenomena in the sky, however, depends on the cosmological model considered. By taking into account the observational bias that will restrict the detection of lensed quasars, identification of these up to a given limiting magnitude will constrain the cosmological parameters.We have investigated the known gravitationally lensed quasars present in the Gaia DR1, and found that a significant number of components of these systems have been measured and are present in the Gaia DR1 catalogue although quasi none of them have all their components detected. We additionally examined the immediate surroundings of QSOs from the large Quasar catalogue, LQAC3, and detected several configurations compatible with gravitational lensing phenomena. A more global strategy to systematically detect the potential candidates in the various releases of the Gaia catalogue is presented.
Detection of spectroscopic binaries: lessons from the Gaia-ESO survey
Authors: Van der Swaelmen Mathieu , Merle Thibault , Van Eck Sophie , Jorissen Alain , Zwitter Tomaž 
Published: March 2018

AbstractThe Gaia-ESO survey (GES; Gilmore et al. (2012), Randich et al. (2013)) is a spectroscopic survey complementing the Gaia mission to bring accurate radial velocities and chemical abundances for 105 stars. Merle et al. (submitted to A&A; see also this volume) developped a tool (DOE) to detect multiple peaks in the cross-correlation functions (CCFs) of GES spectra. Using the GIRAFFE HR10 and HR21 settings, we were able to compare the efficiency of our SB detection tool depending on the wavelength range and resolution. We show that a careful design of CCF masks can improve the detection rate in the HR21 settings. HR21 spectra are similar to the ones produced by the RVS spectrograph of the Gaia mission, though the lower resolution of RVS spectra may result in a lower detection efficiency than the case of HR21. Analysis of RVS spectra in the context of spectroscopic binaries can take advantage of the lessons learnt from the GES to maximize the detection rate.
A pantropically introduced tree is followed by specific ectomycorrhizal symbionts due to pseudo-vertical transmission
Authors: Séne Seynabou , Selosse Marc-André , Forget Mathieu , Lambourdière Josie , Cissé Khoudia , Diédhiou Abdala Gamby , Rivera-Ocasio Elsie , Kodja Hippolyte , Kameyama Norikazu , Nara Kazuhide , Vincenot Lucie , Mansot Jean-Louis , Weber Jean , Roy Mélanie , Sylla Samba Ndao , Bâ Amadou 
Published: March 2018

Abstract
Global trade increases plant introductions, but joint introduction of associated microbes is overlooked. We analyzed the ectomycorrhizal fungi of a Caribbean beach tree, seagrape (Coccoloba uvifera, Polygonacaeae), introduced pantropically to stabilize coastal soils and produce edible fruits. Seagrape displays a limited symbiont diversity in the Caribbean. In five regions of introduction (Brazil, Japan, Malaysia, Réunion and Senegal), molecular barcoding showed that seagrape mostly or exclusively associates with Scleroderma species (Basidiomycota) that were hitherto only known from Caribbean seagrape stands. An unknown Scleroderma species dominates in Brazil, Japan and Malaysia, while Scleroderma bermudense exclusively occurs in Réunion and Senegal. Population genetics analysis of S. bermudense did not detect any demographic bottleneck associated with a possible founder effect, but fungal populations from regions where seagrape is introduced are little differentiated from the Caribbean ones, separated by thousands of kilometers, consistently with relatively recent introduction. Moreover, dry seagrape fruits carry Scleroderma spores, probably because, when drying on beach sand, they aggregate spores from the spore bank accumulated by semi-hypogeous Scleroderma sporocarps. Aggregated spores inoculate seedlings, and their abundance may limit the founder effect after seagrape introduction. This rare pseudo-vertical transmission of mycorrhizal fungi likely contributed to efficient and repeated seagrape/Scleroderma co-introductions.
CRLF1 promotes malignant phenotypes of papillary thyroid carcinoma by activating the MAPK/ERK and PI3K/AKT pathways
Authors: Yu Shi-Tong , Zhong Qian , Chen Ren-Hui , Han Ping , Li Shi-Bing , Zhang Hua , Yuan Li , Xia Tian-Liang , Zeng Mu-Sheng , Huang Xiao-Ming 
Published: March 2018

AbstractPapillary thyroid carcinoma (PTC) is the one of the most common types of endocrine cancer and has a heterogeneous prognosis. Tumors from patients with poor prognosis may differentially express specific genes. Therefore, an analysis of The Cancer Genome Atlas (TCGA) database was performed and revealed that cytokine receptor-like factor 1 (CRLF1) may be a potential novel target for PTC treatment. The objective of the current study was to explore the expression of CRLF1 in PTC and to investigate the main functions and mechanisms of CRLF1 in PTC. PTC tissues exhibited higher CRLF1 expression at both the mRNA and protein levels than it did with normal thyroid tissues. High CRLF1 levels were associated with aggressive clinicopathological features and poor disease-free survival rates. By using loss-of-function and gain-of-function assays, we found that CRLF1 not only increased cell migration and invasion in vitro but also promoted tumor growth both in vitro and in vivo. In addition, CRLF1 induced epithelial–mesenchymal transitions. Overexpression of CRLF1 activated the ERK1/2 and AKT pathways. The oncogenic effects induced by CRLF1 were suppressed by treating the cells with the MEK inhibitor U0126 or the AKT inhibitor MK-2206. These results suggest that CRLF1 enhances cell proliferation and metastasis in PTC and thus may therefore be a potential therapeutic target for PTC.
Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression
Authors: Rani Bhavna , Malfettone Andrea , Dituri Francesco , Soukupova Jitka , Lupo Luigi , Mancarella Serena , Fabregat Isabel , Giannelli Gianluigi 
Published: March 2018

AbstractCancer stem cells (CSCs) niche in the tumor microenvironment is responsible for cancer recurrence and therapy failure. To better understand its molecular and biological involvement in hepatocellular carcinoma (HCC) progression, one can design more effective therapies and tailored then to individual patients. While sorafenib is currently the only approved drug for first-line treatment of advanced stage HCC, its role in modulating the CSC niche is estimated to be small. By contrast, transforming growth factor (TGF)-β pathway seems to influence the CSC and thus may impact hallmarks of HCC, such as liver fibrosis, cirrhosis, and tumor progression. Therefore, blocking this pathway may offer an appealing and druggable target. In our study, we have used galunisertib (LY2157299), a selective ATP-mimetic inhibitor of TGF-β receptor I (TGFβI/ALK5) activation, currently under clinical investigation in HCC patients. Because the drug resistance is mainly mediated by CSCs, we tested the effects of galunisertib on stemness phenotype in HCC cells to determine whether TGF-β signaling modulates CSC niche and drug resistance. Galunisertib modulated the expression of stemness-related genes only in the invasive (HLE and HLF) HCC cells inducing a decreased expression of CD44 and THY1. Furthermore, galunisertib also reduced the stemness-related functions of invasive HCC cells decreasing the formation of colonies, liver spheroids and invasive growth ability. Interestingly, CD44 loss of function mimicked the galunisertib effects on HCC stemness-related functions. Galunisertib treatment also reduced the expression of stemness-related genes in ex vivo human HCC specimens. Our observations are the first evidence that galunisertib effectiveness overcomes stemness-derived aggressiveness via decreased expression CD44 and THY1.
Alteration of endosomal trafficking is associated with early-onset parkinsonism caused by SYNJ1 mutations
Authors: Fasano Dominga , Parisi Silvia , Pierantoni Giovanna Maria , De Rosa Anna , Picillo Marina , Amodio Giuseppina , Pellecchia Maria Teresa , Barone Paolo , Moltedo Ornella , Bonifati Vincenzo , De Michele Giuseppe , Nitsch Lucio , Remondelli Paolo , Criscuolo Chiara , Paladino Simona 
Published: March 2018

AbstractRecently, a new form of autosomal recessive early-onset parkinsonism (PARK20), due to mutations in the gene encoding the phosphoinositide phosphatase, Synaptojanin 1 (Synj1), has been reported. Several genes responsible for hereditary forms of Parkinson’s disease are implicated in distinct steps of the endolysosomal pathway. However, the nature and the degree of endocytic membrane trafficking impairment in early-onset parkinsonism remains elusive. Here, we show that depletion of Synj1 causes drastic alterations of early endosomes, which become enlarged and more numerous, while it does not affect the morphology of late endosomes both in non-neuronal and neuronal cells. Moreover, Synj1 loss impairs the recycling of transferrin, while it does not alter the trafficking of the epidermal growth factor receptor. The ectopic expression of Synj1 restores the functions of early endosomes, and rescues these trafficking defects in depleted cells. Importantly, the same alterations of early endosomal compartments and trafficking defects occur in fibroblasts of PARK20 patients. Our data indicate that Synj1 plays a crucial role in regulating the homeostasis and functions of early endosomal compartments in different cell types, and highlight defective cellular pathways in PARK20. In addition, they strengthen the link between endosomal trafficking and Parkinson’s disease.
Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation
Authors: Ding Yue , Liang Xiaoting , Zhang Yuelin , Yi Li , Shum Ho Cheung , Chen Qiulan , Chan Barbara P. , Fan Huimin , Liu Zhongmin , Tergaonkar Vinay , Qi Zhongquan , Tse Hung-fat , Lian Qizhou 
Published: March 2018

AbstractImmunomodulatory activity of mesenchymal stem cells (MSCs) is largely mediated by paracrine factors. Our previous studies showed that activation of nuclear factor-kappa B (NF-κB) regulates cytokine/growth factor secretion by MSCs. This study aimed to elucidate the role of Rap1 (repressor/activator protein), a novel modulator involved in the NF-κB pathway, in regulating the immunomodulatory potency of MSCs in acute allograft rejection of heart transplantation. The immunosuppressive potency of wild-type MSCs (WT-MSCs) or Rap1-deficient MSCs (Rap1−/−-MSCs) was examined in mice with acute allograft rejection following heart transplantation. With a combination of immunosuppressant rapamycin at a dose of 1 mg/kg/d, WT-MSCs notably prolonged the survival of the transplanted heart compared with Rap1−/−-MSCs. Rap1−/−-MSCs displayed a marked insensitivity to inhibit the mixed lymphocyte reaction (MLR) due to impaired cytokine production and a significantly reduced activity of NF-κB signaling in vitro. Finally, transplantation of encapsulated WT-MSCs greatly prolonged the survival of the heart allograft compared with encapsulated Rap1−/−-MSCs. Our results indicate that Rap1 is essential to maintain the immunomodulatory function of MSCs. Deletion of Rap1 results in impaired immunomodulatory function of MSCs.
Raddeanin A suppresses breast cancer-associated osteolysis through inhibiting osteoclasts and breast cancer cells
Authors: Wang Qiang , Mo Jian , Zhao Chenchen , Huang Kangmao , Feng Mingxuan , He Wenxin , Wang Jiying , Chen Shuai , Xie Zi’ang , Ma Jianjun , Fan Shunwu 
Published: March 2018

AbstractBone metastasis is a severe complication of advanced breast cancer, resulting in osteolysis and increased mortality in patients. Raddeanin A (RA), isolated from traditional Chinese herbs, is an oleanane-type triterpenoid saponin with anticancer potential. In this study, we investigated the effects of RA in breast cancer-induced osteolysis and elucidated the possible mechanisms involved in this process. We first verified that RA could suppress osteoclast formation and bone resorption in vitro. Next, we confirmed that RA suppressed Ti-particle-induced osteolysis in a mouse calvarial model, possibly through inhibition of the SRC/AKT signaling pathway. A breast cancer-induced osteolysis mouse model further revealed the positive protective effects of RA by micro-computed tomography and histology. Finally, we demonstrated that RA inhibited invasion and AKT/mammalian target of rapamycin signaling and induced apoptosis in MDA-MB-231 cells. These results indicate that RA is an effective inhibitor of breast cancer-induced osteolysis.