bluuebunny/crossref_metadata_2025_split huggingface dataset:
OBSERVATIONAL SELECTION BIAS AFFECTING THE DETERMINATION OF THE EXTRAGALACTIC DISTANCE SCALE
Authors: Teerikorpi P. 
Published: July 2002

▪ Abstract  The influence of Malmquist bias on the studies of extragalactic distances is reviewed, with brief glimpses of the history from Kapteyn to Scott. Special attention is paid to two kinds of biases, for which the names Malmquist biases of the first and second kind are proposed. The essence of these biases and the situations where they occur are discussed.The bias of the first kind is related to the classical Malmquist bias (involving the “volume effect”), while the bias of the second kind appears when standard candles are observed at different (true) distances, whereby magnitude limit cuts away a part of the luminosity function. In particular, study of the latter bias in distance indicators such as Tully Fisher, available for large fundamental samples of galaxies, allows construction of an unbiased absolute distance scale in the local galaxy universe where approximate kinematic relative distances can be derived. Such investigations, using the method of normalized distances or of the Spaenhauer diagram, support the linearity of the Hubble law and make it possible to derive an unbiased value of the Hubble constant.
VARIABILITY OF ACTIVE GALACTIC NUCLEI
Authors: Ulrich Marie-Helene , Maraschi Laura , Urry C. Megan 
Published: July 2002

▪ Abstract  A large collective effort to study the variability of active galactic nuclei (AGN) over the past decade has led to a number of fundamental results on radio-quiet AGN and blazars. In radio-quiet AGN, the ultraviolet (UV) bump in low-luminosity objects is thermal emission from a dense medium, very probably an accretion disk, irradiated by the variable X-ray source. The validity of this model for high-luminosity radio-quiet AGN is unclear because the relevant UV and X-ray observations are lacking. The broad-line gas kinematics appears to be dominated by virialized motions in the gravity field of a black hole, whose mass can be derived from the observed motions. The “accretion disk plus wind” model explains most of the variability (and other) data and appears to be the most appropriate model at present. Future investigations are outlined.In blazars, rapid variability at the highest energies (gamma-rays) implies that the whole continuum is relativistically boosted along the line of sight. The general correlation found between variations in TeV gamma rays and in X rays for Mrk 421, and between variations in GeV gamma rays and in the IR–optical–UV bands for 3C 279, two prototype objects, supports models in which the same population of relativistic electrons radiates the low-frequency continuum via synchrotron and the high frequency continuum via inverse Compton scattering of soft photons. Identifying the dominant source of soft photons, which is at present unclear, will strongly constrain the jet physics.
STRATIGRAPHIC RECORD OF THE EARLY MESOZOIC BREAKUP OF PANGEA IN THE LAURASIA-GONDWANA RIFT SYSTEM
Authors: Olsen Paul E. 
Published: July 2002

▪ Abstract  Rift basins of the Central Atlantic Margins (CAM) of North America and Morocco preserve largely continental sequences of sedimentary strata and less important minor basalt flows spanning much of the early Mesozoic. The best known is the Newark basin of New Jersey, New York, and Pennsylvania where an astronomically calibrated magnetic polarity time scale is developed.Lacustrine cycles of Milankovitch origin are commonly present in CAM basins, with the period changing from 10 ky (paleoequator with coals), to 20 ky (4°–10°N), to perhaps 40 ky northward with evaporites. Cycles of ∼100 ky, 413 ky, and ∼2 my are also important.Four mostly unconformity-bounded tectonostratigraphic sequences are present. The Anisian TS I is fluvial and eolian. TS II–TS IV (Late Triassic to Early Jurassic) consist of “tripartite” lacustrine sequences caused by extension pulses. The Newark basin accumulation rate history allows comparison with quantitative rift basin models.The North American plate's slow northward drift resulted in a relative shift of climate, although the rapid humidification during the latest Triassic and Early Jurassic is associated with a sea-level rise. The Triassic-Jurassic mass extinction is of independent origin, plausibly impact related.
RATES OF MOLECULAR EVOLUTION: Phylogenetic Issues and Applications
Authors: Mindell David P. , Thacker Christine E. 
Published: July 2002

▪ Abstract  The proper relationship between systematics practice and our understanding of evolution has been long debated. Systematists seek to avoid assumptions about evolutionary process in their methods, yet a growing body of evidence indicates that patterns in rates of evolution can be used to reduce effects of homoplasy. We review variable evolutionary rates for molecular characters in the context of constraints on mutation and fixation. Some constraints, like the genetic code for protein-coding genes, are consistent in the direction of their effects, whereas others, like population size and cladogenesis frequency, are historically variable within and among lineages. We review methods for assessing rate variability, and we estimate comparative absolute rates of change for five sets of mitochondrial DNAs in 12 vertebrates for application in phylogenetic analyses. Unequal weights for subsets of mitochondrial DNAs improved congruence with the most highly corroborated tree in many but not all cases. The largest data set (12,120 bases) yielded the same tree under all four weighting alternatives. This is consistent with the notion, echoing the law of large numbers, that as data sets increase in size, homoplasy will tend to cancel itself out. Even if this notion has validity, however, evolutionary biology will remain vital in systematics if we want to: match sets of taxa with characters likely to be historically informative (when data sets are not sufficiently large); avoid comparing characters with different histories due to reticulations, horizontal transfer, or lineage sorting; avoid assuming random distribution of homoplasy; be alerted to the possibility of long-branch attraction problems; and understand the cause of the hierarchy of taxa in nature as inheritance of genetic material and descent with modification.
Mistletoe—A Keystone Resource in Forests and Woodlands Worldwide
Authors: Watson David M. 
Published: July 2002

▪ Abstract  Mistletoes are a diverse group of parasitic plants with a worldwide distribution. The hemiparasitic growth form is critical to understanding their biology, buffering variation in resource availability that constrains the distribution and growth of most plants. This is manifested in many aspects of mistletoe life history, including extended phenologies, abundant and high-quality fruits and nectar, and few chemical or structural defenses. Most mistletoe species rely on animals for both pollination and fruit dispersal, and this leads to a broad range of mistletoe-animal interactions. In this review, I summarize research on mistletoe biology and synthesize results from studies of mistletoe-animal interactions. I consolidate records of mistletoe-vertebrate interactions, incorporating species from 97 vertebrate families recorded as consuming mistletoe and from 50 using mistletoe as nesting sites. There is widespread support for regarding mistletoe as a keystone resource, and all quantitative data are consistent with mistletoe functioning as a determinant of alpha diversity. Manipulative experiments are highlighted as a key priority, and six explicit predictions are provided to guide future experimental research.The facts which kept me longest scientifically orthodox are those of adaptation—the pollen-masses in Asclepias—the misseltoe, with its pollen carried by insects and seed by Birds—the woodpecker, with its feet and tail, beak and tongue, to climb the tree and secure insects. To talk of climate or Lamarckian habit producing such adaptation to other organic beings is futile. This difficulty, I believe I have surmounted.     From a letter to Asa Gray by Charles Darwin, 1857.
SOFT LITHOGRAPHY
Authors: Xia Younan , Whitesides George M. 
Published: July 2002

Abstract Soft lithography represents a non-photolithographic strategy based on self-assembly and replica molding for carrying out micro- and nanofabrication. It provides a convenient, effective, and low-cost method for the formation and manufacturing of micro- and nanostructures. In soft lithography, an elastomeric stamp with patterned relief structures on its surface is used to generate patterns and structures with feature sizes ranging from 30 nm to 100 μm. Five techniques have been demonstrated: microcontact printing (μCP), replica molding (REM), microtransfer molding (μTM), micromolding in capillaries (MIMIC), and solvent-assisted micromolding (SAMIM). In this chapter we discuss the procedures for these techniques and their applications in micro- and nanofabrication, surface chemistry, materials science, optics, MEMS, and microelectronics.
Viktor Hamburger and Rita Levi-Montalcini: The Path to the Discovery of Nerve Growth Factor
Authors: Cowan W. Maxwell 
Published: July 2002

▪ Abstract  The announcement in October 1986 that the Nobel Prize for physiology or medicine was to be awarded to Rita Levi-Montalcini and Stanley Cohen for the discoveries of NGF and EGF, respectively, caused many to wonder why Viktor Hamburger (in whose laboratory the initial work was done) had not been included in the award. Now that the dust has settled, the time seems opportune to reconsider the antecedent studies on the relation of the developing nervous system to the peripheral structures it innervates. The studies undertaken primarily to investigate this issue culminated in the late 1950s in the discovery that certain tissues produce a nerve growth–promoting factor that is essential for the survival and maintenance of spinal (sensory) ganglion cells and sympathetic neurons. In this review, the many contributions that Viktor and Rita made to this problem, both independently and jointly, are reexamined by considering chronologically each of the relevant research publications together with some of the retrospective memoirs they have published in the years since the discovery of NGF was first reported. This review is dedicated to Viktor Hamburger on the occasion of his 100th birthday on July 9, 2000, and to Rita Levi-Montalcini to mark her 91st birthday on April 22, 2000, with admiration and affection.
Auditory and Visual Spatial Localization Deficits Following Bilateral Parietal Lobe Lesions in a Patient with Balint's Syndrome
Authors: Phan M. L. , Schendel K. L. , Recanzone G. H. , Robertson L. C. 
Published: July 2002

Abstract
Lesion and electrophysiological studies indicate that the parietal lobes play a role in visual spatial attention and in computing the spatial coordinates of visual input. Fewer studies have investigated the role of the parietal lobe in auditory spatial processing, and an extensive comparison of visual and auditory spatial processing in humans with parietal lobe lesions has yet to be conducted. We have studied such localization abilities in a Balint's syndrome patient (RM) who has bilateral parietal lobe lesions. The results indicated that this patient had a significant deficit in both visual and auditory localization relative to age-matched controls. Unlike the controls, however, RM's auditory localization ability either matched or exceeded his visual localization ability depending on the task. Accordingly, RM exhibited “auditory capture”, but not “visual capture” under conditions where control subjects showed the opposite pattern. These results are consistent with hypotheses that the parietal lobes are involved in creating multiple spatial representations and in shifting from one spatial reference point to another, but suggest that these parietal structures are not necessary for the integration of multiple sensory stimuli resulting in capture effects.
Functional Brain Imaging of Young, Nondemented, and Demented Older Adults
Authors: Buckner Randy L. , Snyder Abraham Z. , Sanders Amy L. , Raichle Marcus E. , Morris John C. 
Published: July 2002

AbstractBrain imaging based on functional MRI (fMRI) provides a powerful tool for characterizing age-related changes in functional anatomy. However, between-population comparisons confront potential differences in measurement properties. The present experiment explores the feasibility of conducting fMRI studies in nondemented and demented older adults by measuring hemodynamic response properties in an event-related design. A paradigm involving repeated presentation of sensory-motor response trials was administered to 41 participants (14 young adults, 14 nondemented older adults, and 13 demented older adults). For half of the trials a single sensory-motor event was presented in isolation and in the other half in pairs. Hemodynamic response characteristics to the isolated events allowed basic response properties (e.g., amplitude and variance) between subject groups to be contrasted. The paired events further allowed the summation properties of the hemodynamic response to be characterized. Robust and qualitatively similar activation maps were produced for all subject groups. Quantitative results showed that for certain regions, such as in the visual cortex, there were marked reductions in the amplitude of the hemodynamic response in older adults. In other regions, such as in the motor cortex, relatively intact response characteristics were observed. These results suggest caution should be exhibited in interpreting simple main effects in response amplitude between subject groups. However, across all regions examined, the summation of the hemodynamic response over trials was highly similar between groups. This latter finding suggests that, even if absolute measurement differences do exist between subject groups, relative activation change should be preserved. Designs that rely on group interactions between task conditions, parametric manipulations, or group interactions between regions should provide valuable data for making inferences about functional-anatomic changes between different populations.
Encoding Processes during Retrieval Tasks
Authors: Buckner Randy L. , Wheeler Mark E. , Sheridan Margaret A. 
Published: July 2002

Abstract
Episodic memory encoding is pervasive across many kinds of task and often arises as a secondary processing effect in tasks that do not require intentional memorization. To illustrate the pervasive nature of information processing that leads to epeisodic encoding, a form of incidental encoding was explored based on the “Testing” phenomenon: The incidental-encoding task was an episodic memory retrieval task. Behavioral data showed that performing a memory retrieval task was as effedctive as intentional instructions at promoting episodic encoding. During fMRI imaging, subjedcts veiewed old and new words adn indicated whether they remembered them. Relevant to encoding, the fate of the new words was examined using a second, surprise test of recognition after the imaging session, fMRI analysis of those new words that were later remembered revealed greater activity in left frontal regions than those that were later forgotten-the same pattern of results as previously observed for traditional incidental and intentional episodic encoding tasks. This finding may offer a partial explanation for why repeated testing improves memory performance. Furthermore, the observation of correlates of episodic memory encoding during retrieval tasks challenges some interpretations that aris from direct comparisons between: encoding tasks and “retrieval tasks” in imaging data. Encoding processes and their neural correlates may arise in many tasks, even those nominally labeled as retrieval tasks by the experimenter.
Identifying Rate-Limiting Nodes in Large-Scale Cortical Networks for Visuospatial Processing: An Illustration using fMRI
Authors: Ng V. W. K. , Bullmore E. T. , de Zubicaray G. I. , Cooper A. , Suckling J. , Williams S. C. R. 
Published: July 2002

Abstract
With the advent of functional neuroimaging techniques, in particular functional magnetic resonance imaging (fMRI), we have gained greater insight into the neural correlates of visuospatial function. However, it may not always be easy to identify the cerebral regions most specifically associated with performance on a given task. One approach is to examine the quantitative relationships between regional activation and behavioral performance measures. In the present study, we investigated the functional neuroanatomy of two different visuospatial processing tasks, judgement of line orientation and mental rotation Twenty-four normal participants were scanned with fMRI using blocked periodic designs for experimental task presentation. Accuracy and reaction time (RT) to each trial of both activation and baseline conditions in each experiment was recorded. Both experiments activated dorsal and ventral visual cortical areas as well as dorsolateral prefrontal cortex. More regionally specific associations with task performance were identified by estimating the association between (sinusoidal) power of functional response and mean RT to the activation condition; a permutation test based on spatial statistics was used for inference. There was significant behavioral-physiological association in right ventral extrastriate cortex for the line orientation task and in bilateral (predominantly right) superior parietal lobule for the mental rotation task. Comparable associations were not found between power of response and RT to the baseline conditions of the tasks. These data suggest that one region in a neurocognitive network may be most strongly associated with behavioral performance and this may be regarded as the computationally least efficient or rate-limiting node of the network.
Delineating Necessary and Sufficient Neural Systems with Functional Imaging Studies of Neuropsychological Patients
Authors: Price C. J. , Mummery C. J. , Moore C. J. , Frackowiak R. S. J. , Friston K. J. 
Published: July 2002

Abstract
This paper demonstrates how functional imaging studies of neuropsychological patients can provide a way of determining which areas in a cognitive network are jointly necessary and sufficient. The approach is illustrated with an investigation of the neural system underlying semantic similarity judgments. Functional neuroimaging demonstrates that normal subjects activate left temporal, parietal, and inferior frontal cortices during this task relative to physical size judgments. Neuropsychology demonstrates that damage to the temporal and parietal regions results in semantic deficits, indicating that these areas are necessary for task performance. In contrast, damage to the inferior frontal cortex does not impair task performance, indicating that the inferior frontal cortex might not be necessary. However, there are two other possible accounts of intact performance following frontal lobe damage: (1) there is functional reorganization involving the right frontal cortex and (2) there is peri-infarct activity around the damaged left-hemisphere tissue. Functional imaging of the patient is required to discount these possibilities. We investigated a patient (SW), who was able to associate words and pictures on the basis of semantic relationships despite extensive damage to the left frontal, inferior parietal, and superior temporal cortices. Although SW showed peri-infarct activation in left extrasylvian temporal cortices, no activity was observed in either left or right inferior frontal cortices. These ªndings demonstrate that activity in extrasylvian temporo-parietal and medial superior frontal regions is sufªcient to perform semantic similarity judgments. In contrast, the left inferior frontal activations detected in each control subject appear not to be necessary for task performance. In conclusion, necessary and sufªcient brain systems can be delineated by functional imaging of brain-damaged patients who are not functionally impaired.
Correctness of Local Probability Propagation in Graphical Models with Loops
Authors: Weiss Yair 
Published: July 2002

Graphical models, such as Bayesian networks and Markov networks, represent joint distributions over a set of variables by means of a graph. When the graph is singly connected, local propagation rules of the sort proposed by Pearl (1988) are guaranteed to converge to the correct posterior probabilities. Recently a number of researchers have empirically demonstrated good performance of these same local propagation schemes on graphs with loops, but a theoretical understanding of this performance has yet to be achieved. For graphical models with a single loop, we derive an analytical relationship between the probabilities computed using local propagation and the correct marginals. Using this relationship we show a category of graphical models with loops for which local propagation gives rise to provably optimal maximum a posteriori assignments (although the computed marginals will be incorrect). We also show how nodes can use local information in the messages they receive in order to correct their computed marginals. We discuss how these results can be extended to graphical models with multiple loops and show simulation results suggesting that some properties of propagation on single-loop graphs may hold for a larger class of graphs. Specifically we discuss the implication of our results for understanding a class of recently proposed error-correcting codes known as turbo codes.
Approximate Life‐Cycle Assessment of Product Concepts Using Learning Systems
Authors: Sousa Inês , Wallace David , Eisenhard Julie L. 
Published: July 2002

SummaryParametric life‐cycle assessment (LCA) models have been integrated with traditional design tools and used to demonstrate the rapid elucidation of holistic, analytical trade‐offs among detailed design variations. A different approach is needed, however, if analytical environmental assessment is to be incorporated in very early design stages. During early stages, there may be competing product concepts with dramatic differences. Detailed information is scarce, and decisions must be made quickly.This article explores an approximate method for providing preliminary LCAs. In this method, learning algorithms trained using the known characteristics of existing products might allow environmental aspects of new product concepts to be approximated quickly during conceptual design without defining new models. Artificial neural networks are trained to generalize on product attributes, which are characteristics of product concepts, and environmental inventory data from pre‐existing LCAs. The product design team then queries the trained artificial model with new high‐level attributes to quickly obtain an impact assessment for a new product concept. Foundations for the learning system approach are established, and then an application within the distributed object‐based modeling environment (DOME) is provided. Tests have shown that it is possible to predict life‐cycle energy consumption, and that the method could be used to predict solid waste, greenhouse effect, ozone depletion, acidification, eutrophication, winter and summer smog.