bluuebunny/crossref_metadata_2025_split huggingface dataset:
Touristes internationaux ou résidents étrangers ?
Authors: GIL DE ARRIBA Carmen , BOUQALLAL Hamid 
Published: February 2018

L’ambition de ce travail est de réfléchir sur les rapports entre tourisme international et migrations résidentielles d’agrément dans le cas concret du Maroc. Dans le contexte de mondialisation des dernières décennies, les interventions de l’Administration marocaine et des investisseurs étrangers ont conduit à un processus de mise en tourisme du territoire se traduisant par l’apparition d’espaces touristico-résidentiels, surtout dans certaines zones du littoral ou dans des villes historiques. Ces espaces adaptés aux besoins des touristes étrangers contribuent à produire et à reproduire des représentations et des imaginaires fondés sur la recherche d’altérité et le désir d’exotisme, utilisés comme éléments d’attraction. Le texte est articulé en cinq sections : la première sert à énoncer la problématique et à présenter les antécédents historiques, alors que la deuxième établit le cadre conceptuel et décrit la méthodologie employée. Les deux sections suivantes traitent des interactions entre tourisme international et tourisme résidentiel, ainsi que des différents effets de ces activités, surtout des points de vue spatial et urbanistique. La dernière section, avant d’établir les conclusions finales, est consacrée à l’analyse des caractéristiques de ces touristes migrants de même qu’aux rapports qu’ils entretiennent avec leurs nouveaux lieux de vie.
Les limites du concept de tourisme résidentiel : étude de cas du caravaning à plein temps
Authors: FORGET Célia 
Published: February 2018

Le caravaning à plein temps, mode de vie choisi par plusieurs millions de Nord-Américains, est-il une forme de tourisme résidentiel ? C’est à cette question que cet article tente de répondre en analysant le concept même de tourisme résidentiel et les concepts avoisinants pour saisir si le caravaning à plein temps présente des points communs avec ceux-ci. Les destinations choisies par les caravaniers, en été comme en hiver, sont-elles liées au tourisme ? Le temps de résidence passé dans ces destinations a-t-il une influence sur la conception qu’ils se font de leur statut de touriste, de migrant ou de résident ? En concentrant mon analyse sur un certain type de caravaniers à plein temps, ceux qui élisent domicile pour plusieurs mois à un même endroit, il sera possible de démontrer que ce mode de vie se distingue à maints égards de ceux généralement liés au tourisme résidentiel ou à la migration de style de vie.
Sociologie des emballages et marketing touristique
Authors: LE BOT Jean-Michel 
Published: February 2018

L’article propose une application au marketing touristique de la sociologie de l’emballage proposée par Franck Cochoy en donnant de cette notion d’emballage une définition élargie. Cela permet d’observer dans un premier temps que le marketing touristique mobilise les mêmes « registres cognitifs » que ceux mobilisés dans d’autres domaines par le packaging, en s’appuyant sur les mêmes logiques de captation : enchaînement, intéressement, engagement et attachement. Mais cela permet aussi de questionner l’unité de ces différentes logiques qui, chez Cochoy, coïncidaient avec les déterminants de l’activité sociale de Max Weber (action traditionnelle, action rationnelle en finalité, action rationnelle en valeur, action affectuelle). Dans cette perspective, l’article interroge plus particulièrement l’unité de la logique d’attachement qui pour Cochoy table sur un registre affectif. L’examen des emballages touristiques met en effet particulièrement en évidence la dualité de cette logique d’attachement et conduit finalement à la décomposer en une logique d’aguichement et une logique d’appariement.
A simple molecular technique for distinguishing species reveals frequent misidentification of Hawaiian corals in the genus Pocillopora
Authors: Johnston Erika C. , Forsman Zac H. , Toonen Robert J. 
Published: February 2018

Species within the scleractinian genus Pocillopora Lamarck 1816 exhibit extreme phenotypic plasticity, making identification based on morphology difficult. However, the mitochondrial open reading frame (mtORF) marker provides a useful genetic tool for identification of most species in this genus, with a notable exception of P. eydouxi and P. meandrina. Based on recent genomic work, we present a quick and simple, gel-based restriction fragment length polymorphism (RFLP) method for the identification of all six Pocillopora species occurring in Hawai‘i by amplifying either the mtORF region, a newly discovered histone region, or both, and then using the restriction enzymes targeting diagnostic sequences we unambiguously identify each species. Using this approach, we documented frequent misidentification of Pocillopora species based on colony morphology. We found that P. acuta colonies are frequently mistakenly identified as P. damicornis in Kāne‘ohe Bay, O‘ahu. We also found that P. meandrina likely has a northern range limit in the Northwest Hawaiian Islands, above which P. ligulata was regularly mistaken for P. meandrina.
UM MODELO MULTICRITÉRIO CONSTRUTIVISTA PARA APOIAR À GESTÃO DA ATIVIDADE DE PESQUISA DA UNIVERSIDADE DE MINDELO
Authors: Cardoso Thuine Lopes , Ensslin Sandra Rolim , Dutra Ademar , Dias Juscelino 
Published: February 2018

Este estudo tem como objetivo construir um modelo de avaliação de desempenho para apoiar à gestão da atividade de pesquisa da Universidade de Mindelo (UM), sediada em Cabo Verde, na África. Para tal, utilizou-se, como instrumento de intervenção, a Metodologia Multicritério de Apoio à Decisão-Construtivista (MCDA-C). A aplicação dessa metodologia permitiu a geração de conhecimento no pró-reitor de pesquisa da UM para identificação dos aspectos relevantes, necessários e suficientes, segundo a sua percepção, para avaliar e gerenciar o contexto. Entre os principais resultados, está a identificação: (i) de cinco áreas de preocupação: Capacitação; Estruturação da Pesquisa; Captação de Recursos; Operacionalização da Pesquisa; e, Resultados da Pesquisa; (ii) de indicadores e do perfil de desempenho da UM; e, (iii) de indicadores com desempenho comprometedor, dentre eles: % de participação docente em eventos científicos no último ano; % de docentes com publicação em revistas de alto fator de impacto nos últimos dois anos; % do corpo docente com doutorado; e, % de pesquisas voltadas a temas ligados a problemas ambientais no último ano. Para esses indicadores, ações de melhorias foram sugeridas para alavancar o desempenho da atividade de pesquisa da UM. Nesse contexto, os autores deste estudo acreditam que a construção de um modelo personalizado para avaliar e gerir a atividade de pesquisa contribuirá para o desenvolvimento da pesquisa científica e para a geração de conhecimento proporcionada por ela.
Biomimetic Superhydrophobic Triboelectric Surface Prepared by Interfacial Self‐Assembly for Water Harvesting
Authors: Zhang Puyang , Zhang Song , Li Xiuzhen , Liu Tao , Zhao Tong , Wang Jinlong , Luo Bin , Cai Chenchen , Liu Yanhua , Shao Yuzheng , Du Guoli , Wang Shuangfei , Nie Shuangxi 
Published: October 2024

AbstractExtracting water from air offers a promising route to address the global challenge of water scarcity. However, bionic engineering surfaces for water harvesting often struggle with efficiently coordinating droplet nucleation and desorption. The recently emerging triboelectric effect at the liquid–solid interface offers a novel approach for developing bionic fog harvesting surfaces. In this study, inspired by Namib Desert beetles and lotus leaves, a biomimetic superhydrophobic surface with nanoscale hydrophilic domains is prepared via interfacial self‐assembly, exhibiting heterogeneous wettability for effective water harvesting. The essence of interfacial self‐assembly lies in the synergy of non‐covalent interaction forces, driving the self‐assembly of nanoparticles into surface micro‐nano hierarchical structures, thereby regulating wettability and increasing potential nucleation sites. Additionally, the triboelectric effect can directly utilize the triboelectric charges to facilitate droplet migration. The triboelectric effect can be generated by flexible mechanical input induced by walking, which enhances interfacial mass transfer, thereby rapidly improving droplet removal and achieving a 39.02% increase in water harvesting efficiency. This study has opened up a new breakthrough for the design of portable and efficient water harvesting systems.
Spider Webs‐Inspired Aluminum Coordination Hydrogel Piezoionic Sensors for Tactile Nerve Systems
Authors: Guan Xiaoyu , Zheng Sai , Luo Jianxun , Liu Xingchen , Wang Xuechuan , Zhang Bingyuan , Zhu Yanxia , Li Dongping , Han Qingxin , Ueda Motoki , An Meng 
Published: October 2024

AbstractPiezoionics, a new frontier that employs mobile ions as energy and charge carriers, plays an important role in new energy and intelligent electronics. However, a significant challenge consists in balancing the structural design of metal ions coordination hydrogel (HG‐MI) piezoionics for current conduction, voltage generation, and especially mechanical adaptability. Herein, inspired by the spider webs' unique structure, a strategy by realizing the full potential of metal‐ligand ions ([(OH)Cl2]3−) to facilitate the keggin‐type structure AlOHAlOH generation together with activate functional carboxyls is introduced. Impressively, the whole property of the product HG‐AlPAC, especially the mechanical performance is improved. For example, the toughness of HG‐AlPAC is 2.75 MJ m−3, more than twofold that of traditional HG‐AlAS/AC/AN samples. Due to the stable fixation of ─Al─OH─ thus promoting Cl− separation upon external force, HG‐AlPAC achieves a piezoionic coefficient of 0.89 mV KPa−1 and energy conversion efficiency of 1.29%, promising for mechanical‐electrical conversion and sensing. Combined with the good mechanical performance with the excellent piezoionic properties, underscores its potential as a tactile nerve system of analgesia patients to prevent them from being injured. This work intends to provide a stride toward mechanically robust self‐powered piezoionic sensors and offer insights into ionotropic materials for energy harvesting, human‐machine interaction, and biointerface.
Electrochemical Sacrificial Alchemy: Crafting Hollow Hydroxide Hierarchy for Practical Aqueous Energy Storage Solution
Authors: Sun Fang‐Fang , Wu Chongchong , Guan Xinwei , Huang Zi‐Hang , Han Xu , Zhang Yue , Li Hui , Song Yu , Ma Tianyi 
Published: October 2024

AbstractEffective utilization of internal active sites in high‐mass loading electrode materials is essential for advancing practical energy storage. Herein, a novel electrochemical sacrificial alchemy for the first time to directly transform the solid Co‐Ni‐Zn carbonate hydroxide (CH) into its hollow structure with a strategic hierarchical architecture is introduced. In contrast to the complex and often cumbersome procedures of traditional methods, the approach is built on the simple electrochemically induced in situ etching and remodeling process. The experimental and theoretical analyses highlight the significant role of electric field force‐induced Zn sacrificial etching and hydroxide redeposition in creating internal cavities and regenerating external active sites, leading to the final hollow hierarchical structure with primary 1D hollow nanorod arrays and secondary reconstructed 2D nanoflakes, effectively exposing abundant energy storage sites. Benefiting from the synergistic effect, the resulting Co‐Ni‐Zn CH exhibited exceptional electrochemical performance. As proof of concept, a modular pouch‐type hybrid supercapacitor (HSC) composed of Co‐Ni‐Zn CH cathode achieved an ultrahigh energy density of 46.9 Wh kg−1. This device can efficiently power consumer electronics with a faster charging speed compared to commercial shared power banks. This research unveils a facile electrochemical approach for structuring electrode materials in energy storage solutions.
Transcytosable and Ultrasound‐Activated Liposome Enables Deep Penetration of Biofilm for Surgical Site Infection Management
Authors: Wang Guowei , Zhang Chengyue , Huang Zixuan , Chen Jifan , Chen Hongjian , Lin Tao , Zhou Zhuxian , Gu Ning , Huang Pintong 
Published: October 2024

AbstractBiofilm‐associated surgical site infection (BSSI) is a common and grievous postoperative complication lacking effective remedies, mainly due to the poor drug accumulation and penetration in the biofilms featured by dense extracellular polymeric substances (EPSs). Here, it is found that the vascular cell adhesion molecule‐1 (VCAM1) is highly overexpressed in the vascular cells of BSSI. It is proposed that the combination of VCAM1‐mediated transcytosis and ultrasonic cavitation can consecutively overcome the biological barriers of vascular endothelial cells and EPS for biofilm eradication. To demonstrate the feasibility, a VCAM1‐targeted and ultrasound (US)‐activated liposome (LPCOTML) loaded with a reactive‐oxygen‐species (ROS)‐responsive lipoid prodrug of oleoyl meropenem, sonosensitizer of lipoid Ce6, and perfluoropentane is developed. LPCOTML can recognize the receptors on vascular cells, and initiate receptor‐mediated transcytosis for transendothelial transport into the BSSI periphery. LPCOTML subsequently transforms from nanoparticle into microbubble via liquid–gas phase transition under US irradiation, triggering strong ultrasonic cavitation to blow up the EPS and deeply penetrate the biofilms. The sonosensitizer Ce6 induces ROS production under US irradiation and triggers the release of meropenem to induce potent antibacterial effect in a BSSI model. This study presents an effective strategy to tackle the biological barriers in BSSI via combining receptor‐mediated transcytosis and ultrasonic cavitation.
Functionalized Quasi‐Solid‐State Electrolytes in Aqueous Zn‐Ion Batteries for Flexible Devices: Challenges and Strategies
Authors: Han Yinlong , Liu Ye , Zhang Yan , He Xiaoxiao , Fu Xianwei , Shi Ruijuan , Jiao Shilong , Zhao Yong 
Published: October 2024

AbstractThe rapid development of wearable and intelligent flexible devices has posed strict requirements for power sources, including excellent mechanical strength, inherent safety, high energy density, and eco‐friendliness. Zn‐ion batteries with aqueous quasi‐solid‐state electrolytes (AQSSEs) with various functional groups that contain electronegative atoms (O/N/F) with tunable electron accumulation states are considered as a promising candidate to power the flexible devices and tremendous progress has been achieved in this prospering area. Herein, this review proposes a comprehensive summary of the recent achievements using the AQSSE in flexible devices by focusing on the significance of different functional groups. The fundamentals and challenges of the ZIBs are introduced from a chemical view in the first place. Then, the mechanism behind the stabilization of the flexible ZIBs with the functionalized AQSSE is summarized and explained in detail. Then the recent progress regarding the enhanced electrochemical stability of the ZIBs with the AQSSE is summarized and classified based on the functional groups on the polymer chain. The advanced characterization methods for the AQSSE are briefly introduced in the following sections. Last but not least, current challenges and future perspectives for this promising area are provided from the authors' point of view.
Deciphering the Multifaceted Immune Landscape of Unresectable Primary Liver Cancer to Predict Immunotherapy Response
Authors: Xue Jun , Yang Shuai , Zhang Si‐Si , Fan Jun , Wu Zi‐Long , Sui Cheng‐Jun , Yang Yong‐Qiang , Zhang Jin‐Feng , Liu Pian , Zhang De‐Jun , Qiu Xin‐Yao , Zhang Tao , Chen Lei , Wu Gang , Wang Hong‐Yang , Tang Jing 
Published: October 2024

AbstractImmunotherapies employing PD‐1/PD‐L1 immune checkpoint inhibitors (ICIs) are vital for primary liver cancer (PLC), but response rates remain unsatisfying. Accurate differentiation of responders from non‐responders to immunotherapy is imperative. Here, single‐cell‐scaled mass cytometry analysis on sequential peripheral blood mononuclear cells (PBMCs) from ICI‐treated PLC patients is conducted, and tissue residence of immune subpopulations is assessed via multiplex immunohistochemistry. In the discovery cohort (n = 24), responders have lower baseline B cell and HLA‐DR+CD8+T cell, and higher CD14+CD16− classical monocyte (CM) proportions. CMs decrease more in responders PBMCs, while HLA‐DR+CD8+T cells conformably amplify after ICI‐exposure. Responsive individuals display upregulated exhaustion and activation markers in peripheral immune lineages. In the expanded cohort of 77 patients, the augment of the B cells in non‐responders is re‐confirmed. Responders demonstrate much higher enrichment of B cells or tertiary lymphoid structures in tumor compared to non‐responders. A prospective model that excelled in early discrimination of responders is developed using generalized linear model and achieves a satisfactory AUC over 0.9 in all three independent cohorts. Integratedly, the study unveils dynamic immune landscapes in PLC patients undergoing ICI‐based therapy, aiding in PLC patient stratification for ICI‐based treatment and fostering new response monitoring strategies.
Cardiac Urea Cycle Activation by Time‐Restricted Feeding Protects Against Pressure Overload‐Induced Heart Failure
Authors: Tan Yanzhen , Li Min , Li Han , Guo Yongzheng , Zhang Bing , Wu Guiling , Li Jia , Zhang Qian , Sun Yang , Gao Feng , Yi Wei , Zhang Xing 
Published: October 2024

AbstractHeart failure is a leading cause of mortality worldwide, necessitating the development of novel therapeutic and lifestyle interventions. Recent studies highlight a potential role of time‐restricted feeding (TRF) in the prevention and treatment of cardiac diseases. Here, it is found that TRF protected against heart failure at different stages in mice. Metabolomic profiling revealed that TRF upregulated most circulating amino acids, and amino acid supplementation protected against heart failure. In contrast, TRF showed a mild effect on cardiac amino acid profile, but increased cardiac amino acid utilization and activated the cardiac urea cycle through upregulating argininosuccinate lyase (ASL) expression. Cardiac‐specific ASL knockout abolished the cardioprotective effects afforded by TRF. Circulating amino acids also protected against heart failure through activation of the urea cycle. Additionally, TRF upregulated cardiac ASL expression through transcription factor Yin Yang 1, and urea cycle‐derived NO contributes to TRF‐afforded cardioprotection. Furthermore, arteriovenous gradients of circulating metabolites across the human hearts were measured, and found that amino acid utilization and urea cycle activity were impaired in patients with decreased cardiac function. These results suggest that TRF is a promising intervention for heart failure, and highlight the importance of urea cycle in regulation of cardiac function.
Injectable Autocatalytic Hydrogel Triggers Pyroptosis to Stimulate Anticancer Immune Response for Preventing Postoperative Tumor Recurrence
Authors: Rao Zhiping , Zhu Yutong , Chen Zhuang , Luo Yi , Yang Zuo , Liu Weijing , Qiao Chaoqiang , Xia Yuqiong , Yang Peng , Ye Dong‐Man , Wang Zhongliang 
Published: October 2024

AbstractModulating immunosuppression while eliminating residual microscopic tumors is critical for inhibiting the postoperative recurrence of triple‐negative breast cancer (TNBC). Although immunotherapy has shown potential in achieving this goal, due to multiple immunosuppression and poor immunogenicity of apoptosis, a satisfactory anti‐recurrence effect still faces the challenge. Herein, an injectable hydrogel‐encapsulated autocatalytic copper peroxide (CP@Gel) therapeutic platform is designed and combine it with the clinical‐grade DNA methyltransferase inhibitor decitabine (DAC) to effectively inhibit TNBC growth and postoperative recurrence via pyroptosis, killing residual cancer cells that bypass apoptosis resistance while also improving immunogenicity and modulating immunosuppression to achieve an intense anti‐tumor immune response. Following injection of the CP@Gel, the sustained release of CP leads to the autocatalytic generation of reactive oxygen species, resulting in caspase‐3 activation, and the pre‐administered DAC inhibits the methylation of Gsdme to elevate the GSDME protein levels, leading to intense pyroptosis and anti‐tumor immune responses. The in vivo results show a 67% elimination of local tumor recurrence via treatment with DAC+CP@Gel, suggesting the successful integration of sustained drug release with autocatalysis and epigenetic modification. The results thus suggest great potential for pyroptosis‐based and injectable hydrogel‐aided strategies for preventing the postoperative recurrence of TNBC.
Electronic Structure Engineering of Single‐Atom Tungsten on Vacancy‐enriched V3S4 Nanosheets for Efficient Hydrogen Evolution
Authors: Xi Min , Zhang Hua , Yang Lingfeng , Long Youyu , Zhao Yifan , Chen Anran , Xiao Qiaozhi , Liu Tingting , Xiao Xuechun , Hu Guangzhi 
Published: October 2024

AbstractConstructing single‐atom catalysts (SACs) and optimizing the electronic structure between metal atoms and support interactions is deemed one of the most effective strategies for boosting the catalytic kinetics of the hydrogen evolution reaction (HER). Herein, a sulfur vacancy defect trapping strategy is developed to anchor tungsten single atoms onto ultrathin V3S4 nanosheets with a high loading of 25.1 wt.%. The obtained W‐V3S4 catalyst exhibits a low overpotential of 54 mV at 10 mA cm−2 and excellent long‐term stability in alkaline electrolytes. Density functional theory calculations reveal that the in situ anchoring of W single atoms triggers the delocalization and redistribution of electron density, which effectively accelerates water dissociation and facilitates hydrogen adsorption/desorption, thus enhancing HER activity. This work provides valuable insights into understanding highly active single‐atom catalysts for large‐scale hydrogen production.
E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction‐Associated Steatohepatitis
Authors: Liu Zheng , Wang Hao , Liang Yuan , Liu Mu , Huang Qiyuan , Wang Mingming , Zhou Jinren , Bu Qingfa , Zhou Haoming , Lu Ling 
Published: October 2024

AbstractMacrophages are essential for the development of steatosis, hepatic inflammation, and fibrosis in metabolic dysfunction‐associated steatohepatitis(MASH). However, the roles of macrophage E2F2 in the progression of MASH have not been elucidated. This study reveals that the expression of macrophage E2F2 is dramatically downregulated in MASH livers from mice and humans, and that this expression is adversely correlated with the severity of the disease. Myeloid‐specific E2F2 depletion aggravates intrahepatic inflammation, hepatic stellate cell activation, and hepatocyte lipid accumulation during MASH progression. Mechanistically, E2F2 can inhibit the SLC7A5 transcription directly. E2F2 deficiency upregulates the expression of SLC7A5 to mediate amino acids flux, resulting in enhanced glycolysis, impaired mitochondrial function, and increased macrophages proinflammatory response in a Leu‐mTORC1‐dependent manner. Moreover, bioinformatics analysis and CUT &Tag assay identify the direct binding of Nrf2 to E2F2 promoter to promote its transcription and nuclear translocation. Genetic or pharmacological activation of Nrf2 effectively activates E2F2 to attenuate the MASH progression. Finally, patients treated with CDK4/6 inhibitors demonstrate reduced E2F2 activity but increased SLC7A5 activity in PBMCs. These findings indicated macrophage E2F2 suppresses MASH progression by reprogramming amino acid metabolism via SLC7A5‐ Leu‐mTORC1 signaling pathway. Activating E2F2 holds promise as a therapeutic strategy for MASH.