bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transition from straight lateral to direct anterior approach in total hip arthroplasty: a retrospective single-centre study
Authors: Visser Lambert C E , Ponds Noa H M , Landman Ellie B M , N Bolink Stijn A A 
Published: November 2024

Introduction: The muscle-sparing direct anterior approach (DAA) for total hip arthroplasty (THA) has gained popularity for reduced postoperative pain and faster rehabilitation. The aim of this study was to evaluate the potential benefits of transitioning from straight lateral approach (SLA) THA to DAA THA, and investigate whether these benefits outweigh potential disadvantages of the DAA learning curve. Method: Patients undergoing surgery between 2015 and 2020 ( n = 2275) were categorised into three periods: pre-transition period (2015-2016) utilizing SLA exclusively, transition period (2017–2018) incorporating both SLA and DAA, and post-transition period (2019–2020) employing only DAA. The Hip disability and Osteoarthritis Outcome Score – Physical function Short-form (HOOS-PS) was recorded pre-surgery and one-year post-surgery. Furthermore, complications, blood loss, duration of surgery and length of stay were compared between groups. Results: A larger improvement in HOOS-PS score was found for DAA in comparison with SLA (37.13 ± 18.62 vs. 32.55 ± 22.83; p < 0.001). Significant improvements were found for the DAA group regarding duration of surgery (70:02 ± 15:54 min vs. 79:47 ± 15:03 min; p < 0,001) and length of stay (1.68 ± 1.80 days vs. 3.39 ± 1.85 days; p < 0,001) compared to the SLA group. Total number of complications was higher for SLA ( n = 87 (9.2%)) compared to DAA ( n = 77 (6.5%); p = 0.018), with more femoral fractures for SLA ( n = 35 (3.7%) vs. n = 6 (0.5%); p < 0.001) whereas more dislocations were found for DAA ( n = 24 (2.0)% vs. n = 7 (0.7%); p = 0.017). More specifically, a higher number of dislocations occurred during the DAA transition period when compared to the SLA pre-transition period ( n = 12 (2.7%) vs. n = 4 (0.6%); p = 0.008). Conclusions: Transitioning from SLA to DAA for THA improves patient-reported outcomes but does not seem to result in a higher overall complication rate. Suggesting the advantages of the DAA outweigh the potential disadvantages of the learning curve.
Ewing Sarcoma of Left Thigh With Nodal, Paraspinal and Soft Tissue Metastatic Lesions: A Case Report
Authors: Waseem Radeyah , Seher Muskan , Ghazal Sohiba , Khan Edrees , Shah Hussain Haider , Hussain Muhammad Sheheryar 
Published: November 2024

Introduction: Ewing sarcoma is a rare and highly aggressive malignancy, mostly involving the axial skeleton. Ewing sarcoma usually affects children and young adults under 20. Usually presenting as a painful swelling and discomfort worsening over time. Case report: We present a case of a 19-year-old female with no known co-morbidities presenting in the Emergency Department with complaints of fever and backache for the past 2 weeks and bilateral lower limb weakness for more than a week. She was started on steroids and broad-spectrum antibiotics and packed cell volume due to low hemoglobin. The screening MRI of the cervical and dorsal spine without contrast revealed signal abnormalities in the vertebral bodies at multiple levels (C2, C5, C6, C7, T1, and T3), as well as within the spinous processes and interspinous musculature. Further evaluation with contrast-enhanced MRI was recommended. The contrast-enhanced MRI showed straightening of the cervical and dorsal spine due to muscular spasm. Additionally, there were small soft tissue components in the left paravertebral region at the level of D3, extending into the epidural space, and epidural components encasing the thecal sac at the levels of D5, D9, and D10 suggestive of neoplastic lesions, most likely metastasis. The morphological and immunohistochemical correlation established the diagnosis of Ewing Sarcoma of the left thigh with nodal, para-spinal, and soft tissue metastatic lesions. Conclusion: Ewing Sarcoma is generally reported in the pediatric population and may come into clinical view based on a plethora of signs and symptoms. Appropriate imaging in the form of X-rays, CT scans, and MRI must be employed to correctly diagnose, and stage the condition.
A corpus investigation of the typology of code-switching between closely related languages: Data from Mandarin–Taiwanese code-switching
Authors: Hsiao Chien-Han 
Published: November 2024

Aims and objectives: The study provides a documentation of the code-switching patterns in typologically similar languages and compares the code-switching patterns between typologically distant versus typologically similar languages. Design: The study examines the scale, type, matrix language, and syntactic categories of spontaneous Mandarin–Taiwanese code-switching as well as their interaction with the speakers’ language dominance and the main language of the conversation. Data and analysis: The study utilized data from a Mandarin–Taiwanese bilingual corpus of 16,186 utterances and conducted frequency analyses. Findings: Due to the large lexical gap in Taiwanese and the higher sociolinguistic status of Mandarin, code-switching between Mandarin and Taiwanese tends to be intra-sentential, classic—with a non-negligible proportion of composite code-switching, and in the direction of Taiwanese to Mandarin. When compared to the code-switching between typologically distant languages, Mandarin–Taiwanese code-switching tends to occur on a smaller scale as most of the translational equivalents in the two languages have a shared syntactic frame, which poses little constraint as to where code-switching can occur. Originality: This study presents a systematic corpus examination of the typological characteristics of code-switching between typologically similar languages. Significance: The results suggest differences in the code-switching patterns in typologically similar versus distant languages and invite future research to reconsider the applicability of the current models of code-switching when studying bilingual speech in typologically similar languages.
Investigating gene expression datasets of hippocampus tissue to discover Alzheimer's disease-associated molecular markers
Authors: Prabha Sneh , Sajad Mohd , Anjum Farah , Hassan Md Imtaiyaz , Shamsi Anas , Thakur Sonu Chand 
Published: November 2024

Background Alzheimer's disease (AD) is an advancing neurodegenerative disorder distinguished by the formation of amyloid plaques and neurofibrillary tangles in the human brain. Nevertheless, the lack of peripheral biomarkers that can detect the development of AD remains a significant limitation. Objective The main aim of this work was to discover the molecular markers associated with AD. Methods We conducted a comprehensive microarray analysis of gene expression data from hippocampus tissue in AD patients and control samples using three microarray datasets (GSE1297, GSE28146, and GSE29378) collected from Gene Expression Omnibus (GEO). The datasets were pre-processed and normalized, revealing 346 significant genes, 103 of which were upregulated and 243 downregulated. The PPI network of significant genes was constructed to detect the top 50 hub genes, which were then further analyzed using Gene Ontology (GO) terms, Kyoto Encyclopedia of Genes and Genomes pathway (KEGG), and GSEA, revealing 47 key genes involved in AD-related pathways. These key genes were then subjected to feed forward loop (FFL) motif analysis for the prediction of transcriptional factors (TFs) and microRNAs (miRNAs) mediated gene regulatory networks. Results The interaction of AD-associated TFs HNF4A, SPI1, EGR1, STAT3, and MYC and miRNAs hsa-miR-155-5p and hsa-miR-16-5p in the transcriptional and post-transcriptional events of 3 upregulated and 10 downregulated genes: H2AFZ, MCM3, MYO1C, AXIN1, CCND1, ETS2, MYH9, RELA, RHEB, SOCS3, TBL1X, TBP, TXNIP, and YWHAZ, respectively, has been identified. The miRNA/TF-mediated three types of the FFL motifs, i.e., miRNA-FFL, TF-FFL, and composite-FFL, were constructed, and seven common genes among these FFL were identified: CCND1, MYH9, SOCS3, RHEB, MYO1C, TXNIP, AXIN1, and TXNIP. Conclusions These findings may provide insights into the development of potential molecular markers for therapeutic management of AD.
Acute Superior Mesenteric Artery Embolism With Infective Endocarditis: Is There a Role for Endovascular Treatment?
Authors: Zhou Xiaoxiang , Teng Jiao , Li Zhenjiang , Zeng Qinglong , He Yangyan , He Yunjun , Xiang Yilang , Wu Ziheng , Li Dongling , Tian Lu , Zhang Hongkun , Zhu Qianqian 
Published: November 2024

Purpose: The purpose of this article is to report a case of acute superior mesenteric artery embolism due to infective endocarditis treated with endovascular therapy. Case Report: A patient with infective endocarditis was admitted to the hospital with abdominal pain, and abdominal enhanced computer tomography showed acute superior mesenteric artery embolism. He underwent urgent percutaneous mechanical thrombectomy and stenting to open the superior mesenteric artery and restore blood supply to the intestine. However, 17 days after the endovascular treatment, a pseudoaneurysm formed next to the stent, which was eventually removed by open surgery. The patient’s prognosis was good at the 1 year follow-up. Conclusion: Endovascular treatment of acute superior mesenteric artery embolism caused by infective endocarditis was able to rapidly restore the intestinal blood supply. However, the possibility of postoperative pseudoaneurysm needs to be guarded against. Clinical Impact This study will provide clinical treatment guidance for acute superior mesenteric artery embolism caused by infectious endocarditis. Endovascular treatment may rapidly alleviate intestinal ischemia and reduce the risk of intestinal necrosis, but it cannot completely eliminate infectious emboli, which may lead to further development of pseudoaneurysms.
Performance enhancement of non-toxic and bio-based textile finishes through novel and sustainable ozonation
Authors: Akhtar Khurram Shehzad , Anam Wardah , Mohsin Muhammad , Sardar Shaheen , Qutab Haji Ghulam 
Published: November 2024

Most effective and durable finishes for cotton fabrics typically contain toxic and sometimes carcinogenic chemicals. Although certain bio-based alternative finishes have been reported in literature but these alternatives are usually less effective than conventional toxic finishes. To improve the performance of bio-based finishes, this paper develops and improves a novel and ecofriendly finishing process for 100% cotton fabric, based on ozone treatments in very controlled amount for the first time. Four types of bio-finishes including citric acid, stearic acid, diammonium hydrogen phosphate and fatty acid amide, for easy care, water repellency, fire retardancy and softness properties respectively were used in this research. For each finish, three ozone-based finishing processes; pre-ozonation, in-situ ozonation, and post-ozonation were developed and optimized. For all four types of bio finishes, fabrics with 20% post ozonation exhibited superior finish performance. Crease recovery angle increased from 121° to 194°, water repellency rating improved from rating 0 to 90, char length decreased from 26.6 cm to 10.8 cm and bending length decreased from 2.16 mm to 1.1 mm by using bio-based finishes with ozone exposure without compromising mechanical and comfort properties of cotton fabrics. SEM, FTIR and XRD analysis were also performed on ozone exposed and finished fabrics.
Hybrid management of aberrant subclavian artery: A systematic review and meta-analysis
Authors: Kordzadeh Ali , Mouhsen Mohamed IMM , Chan Deona ML , Singh Arvind , Gadhvi Vijay M 
Published: November 2024

Objective To elucidate the short- and long-term mortality, morbidity, and endoleak incidences in the hybrid management of aberrant subclavian artery (ASA). Methods A systematic review and meta-analysis of 99 articles comprising n = 272 cases using PRISMA were supplemented by Cohen’s Kappa for assessor consistency. The analysis involved a random-effect model, odds ratios (ORs) with 95% confidence intervals, tests of heterogeneity, and probability. This review was registered with the International Prospective Register of Systematic Reviews (CRD42023405011). Results The 30-day mortality was 4.6% (95% CI: 1.4%–14.4%) with an overall mortality of 7.3% (95% CI: 2.9%–18.7%) demonstrating a 1.2% increase in mortality per decade of life beyond 60 years. The reported morbidity was 7.6% (95% CI: 3.7%–15.7%) and higher in males albeit higher age ( p < .05) (67 vs 59 years). The endoleak incidence stood at 7.8% (95% CI: 3.3%–18.3%) with Type-I the as prominent (48%). Rupture presentation was in 3%, whilst esophageal fistulation ( n = 2/3) was associated with morbidity of 66%. Treatment varied, with TEVAR and carotid-subclavian bypass being the most common modality of the choice. The median follow-up was 12 months (IQR, 1–60 months). Conclusion The observed incidence of mortality, morbidity, and endoleak shows the current role of the hybrid approach in managing ASA. These results emphasize the critical role of detailed surgical planning, combined endovascular and open expertise, and the necessity for a common registry to monitor long-term outcomes.
Collateral vessel size and number could predict severe dissection after balloon angioplasty in patients with femoropopliteal artery chronic total occlusion
Authors: Acar Emrah , Donmez Ibrahim , Güneş Yilmaz , Sincer Isa , Izgi Ibrahim Akin 
Published: November 2024

Objective Collateral vessels develop from pre-existing arterioles in response to shear stress from arterial stenosis and mechanosensor activation. Animal studies suggest that these vessels increase in number and size after arterial occlusion, potentially offering a natural bypass and protection against critical limb ischemia. Efforts to enhance collateral vessel growth aim to improve walking performance in peripheral arterial disease (PAD). Factors influencing collateral vessel formation include plaque accumulation, tissue components, and comorbid conditions. Balloon angioplasty is a primary treatment for PAD but often leads to vessel dissection, with severe dissections linked to reduced long-term patency and requiring additional treatments. The relationship between collateral vessel characteristics and dissection severity remains unexplored. Materials and Methods This retrospective study analyzed endovascular treatments for femoropopliteal chronic total occlusion (FP-CTO) in 824 limbs of 706 PAD patients from January 2018 to May 2023. Exclusion criteria included prior treatments, severe aortoiliac and common femoral artery disease, and deep femoral artery disease. The final cohort comprised 410 limbs from 387 patients. Data on risk factors, lesion characteristics, and procedural details were collected. Collateral vessels were assessed by grade and number, and vessel dissection was categorized from Type A to Type F. Multivariate logistic regression identified predictors of severe dissection. Results Severe dissection was more frequent in TASC II C/D lesions and in patients with longer FP-CTO lengths, CTOP class-4 plaque morphology, flush ostial CTO, severe calcification, and large or numerous collateral vessels. Significant predictors of severe dissection included end-stage renal disease, FP-CTO length, CTOP class-4, flush ostial CTO, severe calcification, and large collateral vessels. Conclusion Longer CTO lengths and complex plaque characteristics increase the risk of severe dissection during balloon angioplasty. Large and numerous collateral vessels are associated with severe dissection. Severe dissection is more common in complex lesions and those with end-stage renal disease. The findings suggest that plaque compliance and collateral vessel characteristics are crucial in assessing dissection risk, highlighting the need for further research with larger cohorts and advanced imaging techniques.
Carbamazepine treatment of myotonia congenita in a cat
Authors: Lopez Bonilla Genesis V , Parsley Elizabeth , Shelton G Diane , Faissler Dominik 
Published: November 2024

Case summary A 2-year-old female intact domestic shorthair cat was referred to the neurology service at the Foster Hospital for Small Animals as a result of lifelong weakness, seizure-like episodes after excitement, muscle spasms, stiffness of the limbs and shortness of breath. A diagnosis of myotonia congenita (MC) was made based on compatible history, clinical signs and electromyography findings, and excluding other causes of muscle weakness using muscle biopsy, baseline bloodwork and echocardiography. Initial treatment with procainamide had overall low efficacy. The cat was then switched to carbamazepine, which provided long-term improvement in clinical signs at a dosage of 7.4 mg/kg PO q12h with no observed clinical side effects. Relevance and novel information To date, there is only a single case report describing the successful treatment of MC in cats, and no report describing the use of carbamazepine to treat this condition in this species. This anti-convulsant medication was shown to be anecdotally effective in the case reported. Further research is needed to categorize the metabolism, pharmacokinetics, tolerance, dose range and efficacy of carbamazepine in cats with and without MC.
Assessing the Elasticity of the Flexor Pronator Muscles After Throwing Using Ultrasound Shear Wave Elastography
Authors: Mukohara Shintaro , Mifune Yutaka , Inui Atsuyuki , Nishimoto Hanako , Kurosawa Takashi , Yamaura Kohei , Shinohara Issei , Hoshino Yuichi , Matsushita Takehiko , Matsumoto Tomoyuki , Kuroda Ryosuke 
Published: November 2024

Background: The medial ulnar collateral ligament (UCL) of the elbow joint is the primary restraint to valgus stress during the throwing motion. The flexor pronator muscles (FPMs) also stabilize the elbow joint against valgus forces; however, assessment of FPM stiffness in baseball players has been limited. Purpose: To use ultrasound shear wave elastography (USWE) to evaluate the change in tissue elasticity of the FPMs due to pitching. Study Designs: Descriptive laboratory study. Methods: Included were 14 healthy male amateur baseball players (mean age, 28.0 ± 2.6 years) who had played intermediate-level high school or college baseball. The tissue elasticity of the flexor digitorum superficialis (FDS) in the superficial layer of the FPMs and the flexor digitorum profundus (FDP) in the deep layer of the FPMs were measured using USWE before, immediately after, and 24 hours after a throwing session of 100 pitches. The intra- and interrater reliability of the measurements were evaluated using the Pearson correlation coefficient and intraclass correlation coefficient (ICC). The elasticity of each muscle was analyzed using repeated-measures analysis of variance followed by post hoc analysis. Results: Reliability of the USWE measurements was good to excellent (intrarater ICCs, 0.78-0.94; interrater ICCs, 0.85-0.96). The mean tissue elasticity values before, immediately after, and 24 hours after pitching were 22.3 ± 4.4, 41.0 ± 13.8, and 38.3 ± 11.2 kPa, respectively, for the FDS and 27.1 ± 5.8, 48.0 ± 22.3, and 29.6 ± 11.5 kPa, respectively, for the FDP. For both the FDS and FDP, elasticity was significantly higher immediately after pitching than before pitching ( P < .001 and P = .0027, respectively). While the elasticity of the FDS at 24 hours after pitching remained significantly higher compared with before pitching ( P = .0011), the elasticity of the FDP at 24 hours decreased to the same level as before pitching ( P = .91). Conclusion: Results using USWE indicated that the elasticity of the FDS did not decrease 24 hours after pitching and remained significantly higher than before pitching, suggesting that it may not be fully functioning as a dynamic stabilizer during this period. Clinical Relevance: Pitching in such a condition may result in greater stress on the UCL and increase the risk of UCL injury.
Clinical use of ACQUIRE Therapy for Children Diagnosed With CASK-Gene Related Disabilities
Authors: Wallace Dory A , Rebekah Trucks Mary , DeLuca Stephanie C 
Published: November 2024

Objective: To report practice based evidence built on clinical findings where an intensive therapeutic approach called ACQUIRE Therapy was used as a rehabilitation/habilitation tool for children diagnosed with CASK mutations. ACQUIRE Therapy delivery is based on principles of learning and guided by a therapeutic framework often used in the delivery of intensive therapy. Design: Clinical Cohort. Setting: Natural environments (eg, home-like environment). Participants: A total of 20 females, 12 to 128 months, mean age = 44.75 (SD = 31.64). Intervention: Trained Occupational therapists delivered high-dosage rehabilitation for an average of 64.06 hours (SD = 12.91) across 4 weeks. ACQUIRE Therapy targeted cross-domain intervention targets often associated with executive control and praxis. Main outcome measures: Clinical data was examined from the following sources; therapist daily treatment documentation (eg, therapy goals, video recordings, daily therapy logs, and discharge documentation). Results: Receptive communication improved in all children. The most common motor skill improvements occurred in trunk control occurring in 33% of children; followed by, gross reaching abilities in 21% of children; fine-motor skills in 19%; head control in 15%; and mobility in 12%. Documentation of cognitive-motor pairing of skills was documented in all children. Conclusions: Diagnosis specific intervention targets (eg, attention and cognitive-pairing skills) need to be considered when providing therapeutic services to children with CASK-gene mutations and other forms of Global Developmental Delay. Clinicaltrials.gov registration number is NCT03325946. Date of registration: 1 May 2013. Trial Dates: December 2014 and October 2023. https://clinicaltrials.gov/study/NCT03325946?locStr=Roanoke,%20VA&country=United%20States&state=Virginia&city=Roanoke&cond=Cerebral%20Palsy&intr=Intensive%20therapy&rank=2
INCA033989: the first shot on goal for MPNs?
Authors: Benlabiod Camelia , Psaila Bethan 
Published: November 2024

Abstract
In this issue of Blood, Reis et al1 identify a monoclonal antibody, INCA033989, that selectively targets mutant calreticulin (mutCALR) in myeloproliferative neoplasms (MPNs), inhibiting its oncogenic activity without affecting normal hematopoiesis.