bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic design of an attribute control chart for monitoring mean life based on multiple deferred state sampling
Authors: Balamurali S. , Jeyadurga P. 
Published: November 2018

AbstractIn this paper, we design an attribute np control chart using multiple deferred state (MDS) sampling under Weibull distribution based on time truncated life test. This chart is constructed for monitoring the variation of mean life of the product in a manufacturing process. The optimal parameters of MDS sampling and the control limit coefficients are determined so that the in‐control average run length (ARL) is as close as to the target ARL. The optimal parameters of MDS sampling are sample size and number of successive subgroups required for declaring the current state of process. Out‐of‐control ARL is considered as a measure of the performance of proposed chart and reported with determined optimal parameters for various shift constants. The out‐of‐control ARL of the proposed chart obtained under various distributions is compared with each other. The performance of proposed control chart is compared with the performance of the existing control chart designed under single sampling. In addition, the economic design of proposed chart using variable sampling interval scheme is discussed, and sensitivity analysis on expected costs is also investigated.
A pilot community‐based randomized comparison of speech generating devices and the picture exchange communication system for children diagnosed with autism spectrum disorder
Authors: Gilroy Shawn P. , Leader Geraldine , McCleery Joseph P. 
Published: November 2018

A pilot community‐based randomized controlled trial was conducted to compare the effects of the Picture Exchange Communication System (PECS) to a teaching sequence using a high‐tech Speech Generating Device (SGD) to teach social communication behaviors. The two approaches were compared to evaluate the effectiveness of the newer, more high‐tech intervention using technology to improve social and communicative behavior of children diagnosed with Autism Spectrum Disorder. A total of 35 school‐age children were randomized to either a high‐tech (SGD device) or low‐tech (PECS cards) form of Augmentative and Alternative Communication (AAC). Study participants received 4 months of communication training delivered in their classrooms, and the primary outcome measures of the trial were several functional communication skills emphasized in the PECS teaching sequence. Results indicated that both high‐tech and low‐tech AAC approaches resulted in significant improvements in communication, and that these improvements did not differ significantly between the two approaches. These findings support the use of high‐tech AAC, and highlight the need for evidence‐based guidelines for its use as well as evaluation with individuals with a range impairments and disabilities. Autism Research 2018, 11: 1701–1711. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryThis study compared the effectiveness of a free and open‐source app for teaching social and communicative behavior to children with autism spectrum disorder (ASD) to traditional picture card approaches. Thirty‐five children with ASD were randomized to a picture card or app‐based intervention and both treatment approaches resulted in significant improvements in social and communicative behavior. These data indicated that both “high‐tech” and “low‐tech” interventions were effective for improving behavior and that there was not a significant difference between the two approaches.
Auditory–visual misalignment: A theoretical perspective on vocabulary delays in children with ASD
Authors: Venker Courtney E. , Bean Allison , Kover Sara T. 
Published: November 2018

In this commentary, we describe a novel theoretical perspective on vocabulary delays in children with autism spectrum disorder (ASD)—a perspective we refer to as auditory–visual misalignment. We synthesize empirical evidence that: (a) as a result of differences in both social and nonsocial visual attention, the auditory–visual statistics available to children with ASD for early word learning are misaligned; (b) this auditory–visual misalignment disrupts word learning and contributes to the vocabulary delays shown by children with ASD; and (c) adopting a perspective of auditory–visual misalignment has important theoretical and clinical implications for understanding and supporting vocabulary development in children with ASD. Theoretically, the auditory–visual misalignment perspective advances our understanding of how attentional differences impact vocabulary development in children with ASD in several ways. By adopting the point of view of the child, we provide a framework that brings together research on social and domain‐general visual attention differences in children with ASD. In addition, the auditory–visual misalignment perspective moves current thinking beyond how misalignment disrupts vocabulary development in the moment, and considers the likely consequences of misalignment over developmental time. Finally, considering auditory–visual misalignment may assist in identifying active ingredients of existing language interventions or in developing new interventions that deliver high quality, aligned input. Future research is needed to determine how manipulating auditory–visual alignment changes word learning in ASD and whether the effects of auditory–visual misalignment are unique to ASD or shared with other neurodevelopmental disorders or sources of language impairment. Autism Research 2018, 11: 1621–1628. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryThis article describes a new way of thinking about vocabulary delays in children with autism spectrum disorder (ASD). We suggest that children with ASD may have difficulty learning words because their attention is not tuned in to what is most important for learning, creating a mismatch between what they see and what they hear. This perspective brings together research on different types of attentional differences in people with ASD. It may also help us to understand how language interventions work.
A sustainability framework for assessing studies about marginal lands for planting perennial energy crops
Authors: Jiang Wei , Jacobson Michael G. , Langholtz Matthew H. 
Published: November 2018

AbstractOne of the issues with large‐scale perennial energy crop production is increasing land use competition between ‘food and feed’ and ‘fuel’. A commonly suggested solution is to limit energy crop plantation to marginal lands. However, the concept and the methods used to assess marginal lands remain vague and inconsistent across bioenergy‐related studies. We propose a sustainability‐based framework to review and classify studies for marginal lands used for bioenergy crops. This framework innovatively puts the marginal land in a sustainability‐based framework, showing the interaction of biophysical, socioeconomic, qualitative, and quantitative assessments. We found that current studies lack integration of biophysical and socioeconomic considerations in the marginal land analysis. They also lack qualitative approaches to assess marginal land. We suggest that future work should emphasize integrating biophysical, socioeconomic, quantitative, and qualitative analysis for sustainable marginal land identification and use. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd
A novel lncRNA‐miRNA‐mRNA network analysis identified the hub lncRNA RP11‐159F24.1 in the pathogenesis of papillary thyroid cancer
Authors: Jiang Wei , Zhan Hua , Jiao Yanyan , Li Sha , Gao Weixu 
Published: November 2018

AbstractPapillary thyroid cancer (PTC) is one of the most common cancers worldwide, and its carcinogenesis is influenced by a complex network of gene interactions. In this study, the microarray expression profile was re‐annotated into a lncRNA‐mRNA biphasic profile. LncRNA‐mRNA interactions were confirmed by established miRNA‐RNA data and hypergeometric test. Then, a PTC‐related lncRNA‐miRNA‐mRNA network (PTCRN) was constructed by integrating differentially expressed genes with the RNA‐RNA networks. The new network consisted of 21 lncRNAs, 241 mRNAs and 803 edges. To prioritize PTC‐related genes, we performed topological analysis and random walk with restart (PWR) algorithm analysis of PTCRN. Both analyses identified lncRNA RP11‐159F24.1 as a hub node in the network, which could interact with 47 mRNAs by sponging miR‐485. In functional enrichment analysis, these interacting mRNAs were associated with the pathways in cancer. In validation, RP11‐159F24.1 (up‐regulated; P = 0.0013) showed an opposite expression pattern with its target miR‐485 (down‐regulated; P = 0.0013) in PTC, indicating that the RP11‐159F24.1/miR‐485/mRNAs axis might play an important role in the development of PTC. In conclusion, this study has constructed a PTC‐related lncRNA‐miRNA‐mRNA network and identified the hub lncRNA RP11‐159F24.1 in the tumorigenesis, which provided novel insights to explore the underlying mechanism of PTC.
The Double Palatal Graft: A Novel Management of Severe Vertical and Horizontal Soft Tissue Deficiency
Authors: Ragab Omar 
Published: November 2018

IntroductionManagement of a severe soft tissue defect in the anterior esthetic zone is challenging, especially when associated with a palatal cleft. This case report describes a novel technique to augment soft tissue thickness and height with a procedure that combines two different soft tissue grafting techniques in one step.Case PresentationA patient presented to the author's private practice with a unilateral cleft lip and palate with a severe vertical and horizontal soft tissue deficiency at the cleft site. Double graft was used to correct the soft tissue defect in one session; one as a pedicle harvested from the palate close to the defect, and the other as a partially de‐epithelialized free graft harvested from the other side of the palate. Both grafts were sutured overlying each other as a double graft. The pedicle graft was sutured at the base of the labial flap, whereas the partially de‐epithelialized free graft was adapted to the recipient site, which included labial and palatal pouches, overlying the pedicle. After 3 months, clinical outcome exhibited favorable results in the form of ample gain in both volume and quality of the soft tissue, restoration of the level of the mucogingival junction, and closure of the palatal cleft.ConclusionThe technique described in this case report could be considered as a method to augment soft tissue volume and quality prior to hard tissue augmentation in severe soft tissue defects.
Use of Transalveolar Sutures for Anchorage of a Resorbable Membrane During Horizontal Ridge Augmentation
Authors: Golob Deeb Janina , McCormack Danielle , Laskin Daniel M. , Deeb George R. 
Published: November 2018

IntroductionReconstruction of the hard tissue components plays an important role in site development for dental implant placement Barrier membranes are often used to contain the graft material and exclude soft tissue ingrowth. Anchorage of the membrane is extremely important. This report describes the use of transalveolar sutures for barrier membrane fixation to the alveolus.Case PresentationThis report describes two cases involving an edentulous mandible and a partially edentulous maxilla undergoing horizontal ridge augmentation to develop future implant sites in which the anatomic conditions and thin supporting bone made the placement of tacks or screws difficult, and transalveolar sutures were used for membrane fixation.ConclusionsIn horizontal alveolar ridge augmentation proper anchorage of the membrane can present a clinical challenge. The technique described, which is applicable to both jaws, can be used as a planned or rescue method when tacks or screws cannot be used.
How do counsellors and psychotherapists understand diet and nutrition as part of the therapy process? A heuristic study
Authors: Terry Nicola , Reeves Andrew 
Published: November 2018

AbstractBackgroundOpinion and information in the public domain suggest that an individual's dietary and nutritional intake may be an important factor in both their physical and mental health. However, at this time in the counselling and psychotherapy field, it is not common for therapists to address issues of dietary intake and nutrition with clients.AimsThis qualitative heuristic study explores the perceptions and beliefs of qualified counsellors and psychotherapists, exploring how they understand dietary and nutritional information to be relevant as part of the therapeutic process with clients.MethodSix participants were recruited through email, journal advert, poster and leaflet distribution. Data were gathered with semi‐structured telephone interviews and analysed using interpretative phenomenological analysis.FindingsSeventeen themes were identified and organised under four master themes: (A) personal aspects of the therapist; (B) therapeutic approach and philosophy; (C) diet and nutrition within the therapy process; and (D) considering ethical practice.ImplicationsImplications for practice include the consideration of multidisciplinary working and developing appropriate training for practitioners in this area.
Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition between USP2 and USP7
Authors: Vamisetti Ganga B. , Meledin Roman , Gopinath Pushparathinam , Brik Ashraf 
Published: November 2018

AbstractDeubiquitinases are important components of the protein regulatory network and, hence, constitute a tempting drug target. We report herein structure–activity relationship studies to develop halogen‐substituted isoquionoline‐1,3‐dione‐based inhibitors of the deubiquitinase USP2. In contrast to our previous reports, the best compound discovered was found to act through a reactive oxygen species independent, uncompetitive mechanism with an IC50 of 250 nm. We show the crucial role of halogens in the common scaffold to provide potency and selectivity of our compound, where the introduction of the fluorine atom completely switches the selectivity of the inhibitor between USP2 and USP7. Our cellular studies highlight the potential applicability of the reported compound for in vivo experiments. The discovery of the isoquinoline‐1,3‐dione core and the knowledge obtained with regard to halogen substituents provide a platform towards understanding USP2 inhibition and the development of highly selective next‐generation deubiquitinase inhibitors.
Toll‐like receptor 4 promoter polymorphisms in a familial mediterranean fever patient with asymptomatic bacteriuria
Authors: Kawamoto Shinichiro , Masutani Ryota , Kurata Keiji , Shima Etsuko , Iwatani Yoshinori , Takubo Takayuki 
Published: November 2018

Key Clinical MessageA periodic fever, due to inherited inflammatory disorders, can be misdiagnosed as a common infection, when a possible pathogen is detected from a patient. TLR4 SNPs that are responsible for asymptomatic bacteriuria might disturb the pathophysiology of familial Mediterranean fever without MEFV mutations.
Structure Sensitivity in Hydrogenation Reactions on Pt/C in Aqueous‐phase
Authors: Sanyal Udishnu , Song Yang , Singh Nirala , Fulton John L. , Herranz Juan , Jentys Andreas , Gutiérrez Oliver Y. , Lercher Johannes A. 
Published: November 2018

AbstractHydrogenation of phenol and of the benzaldehyde carbonyl group catalyzed by Pt are structure sensitive in aqueous phase. The intrinsic reaction rates are directly proportional to the average size of the Pt particles. This trend is indifferent of the genesis of the reduction equivalents, i. e., dissociation of H2 or proton reduction under cathodic potential. It is concluded that the structure sensitivity is caused by the ensemble size sensitivity of the adsorption of the aromatic molecules, which is favored on (100) and (111) surfaces of larger particles. For electrocatalytic reduction, this structure sensitivity implies that hydrogen evolution increases in rate relative to hydrogen addition to reacting substrates as the size of Pt particles decreases.
Preparation of Zn3In2S6/TiO2 for Enhanced CO2 Photocatalytic Reduction Activity Via Z‐scheme Electron Transfer
Authors: She Houde , Wang Yan , Zhou Hua , Li Yuan , Wang Lei , Huang Jingwei , Wang Qizhao 
Published: November 2018

AbstractPhotocatalytic reduction of CO2 is increasingly attracting research interest for the growing concerns about climate change resulted from the greenhouse effect due to the industrial emission of CO2. In this paper, we report the synthesis of Zn3In2S6 modified TiO2 nanocomposite via a facial hydrothermal method. The samples were characterized by photoluminescence spectra (PL), UV‐vis diffuse reflectance spectra (DRS), X‐ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscope (TEM), X‐ray photoelectron spectroscopy (XPS) and energy dispersive X‐ray spectroscopy (EDS). The production rate of CO from CO2 is dramatically improved over the obtained composite catalyst. The contact between Zn3In2S6 and TiO2 is responsible for this ameliorated photocatalytic activity because of the formation of the Z‐scheme charge transfer mechanism which favors the separation of photo‐induced charges.
Hierarchical Microspheres of Aggregated Silicon Nanoparticles with Nanometre Gaps as the Anode for Lithium‐Ion Batteries with Excellent Cycling Stability
Authors: Wang Mingshan , Ma Yan , Jiang Jianyang , Huang Yun , Li Xing , Zheng Jianming , Qin Changdong , Yan Pengfei , Cao Guozhong 
Published: November 2018

AbstractNovel hierarchical microspheres of aggregated silicon nanoparticles (p‐Si microsphere) with nanometre gaps have been synthesized through reverse microemulsion in combination with a modified magnesiothermic reduction approach using silica (∼200 nm) as the precursor. The hierarchical porous structure of p‐Si microspheres is composed of abundant intergranular gaps (100–200 nm) in the interconnected nanosized Si particles, along with ultrafine Si nanosized grains (∼5 nm) and intragranular voids formed in interconnected nanosized Si particles. The hierarchical microspheres of aggregated Si nanoparticles possess a high specific surface area of 136 m2 g−1 and can achieve a high tap density of 0.3 g cm−3. Such a novel microstructure with a large surface area and void gaps between interconnected Si nanoparticles can accommodate the volume change of Si during the lithium ion (Li+) alloying/dealloying process. Meanwhile, the mesoporous structure facilitates Li+ penetration into the nano‐Si grain interface, significantly shortening the Li+ diffusion pathway as well as enhancing the heterogeneous reaction sites. Such hierarchical microspherical Si anodes demonstrated excellent cycling stability, delivering reversible capacity of 845 mAh g−1 after 200 cycles at 0.2 A g−1 and rate performance with a high reversible capacity of 681 mAh g−1 at 1 A g−1 with 97 % of initial capacity retention.
Competitive Metal Coordination of Hexaaminotriphenylene on Cu(111) by Intrinsic Copper Versus Extrinsic Nickel Adatoms
Authors: Lischka Matthias , Dong Renhao , Wang Mingchao , Martsinovich Natalia , Fritton Massimo , Grossmann Lukas , Heckl Wolfgang M. , Feng Xinliang , Lackinger Markus 
Published: November 2018

AbstractThe interplay between the self‐assembly and surface chemistry of 2,3,6,7,10,11‐hexaaminotriphenylene (HATP) on Cu(111) was complementarily studied by high‐resolution scanning tunneling microscopy (STM) and X‐ray photoelectron spectroscopy (XPS) under ultra‐high vacuum conditions. To shed light on the competitive metal coordination, comparative experiments were carried out on pristine and nickel‐covered Cu(111). Directly after room‐temperature deposition of HATP onto pristine Cu(111), self‐assembled aggregates were observed by STM, and XPS results indicated still protonated amino groups. Annealing up to 200 °C activated the progressive single deprotonation of all amino groups as indicated by chemical shifts of both the N 1s and C 1s core levels in the XP spectra. This enabled the formation of topologically diverse π–d conjugated coordination networks with intrinsic copper adatoms. The basic motif of these networks was a metal–organic trimer, in which three HATP molecules were coordinated by Cu3 clusters, as corroborated by the accompanying density functional theory (DFT) simulations. Additional deposition of more reactive nickel atoms resulted in both chemical and structural changes with deprotonation and formation of bis(diimino)–Ni bonded networks already at room temperature. Even though fused hexagonal metal‐coordinated pores were observed, extended honeycomb networks remained elusive, as tentatively explained by the restricted reversibility of these metal–organic bonds.
Unusual Fusion of α‐Fluorinated Benzophenones under McMurry Reaction Conditions
Authors: Akhmetov Vladimir , Feofanov Mikhail , Ioutsi Vitaliy , Hampel Frank , Amsharov Konstantin 
Published: November 2018

AbstractBy exposure of α‐fluorinated benzophenones to McMurry reaction conditions, we have observed the remarkable formation of 9,10‐diphenylanthracene derivatives. This unexpected transformation necessitates the cleavage of the exceptionally stable aromatic C−F bond under mild McMurry conditions. In this work, the condensation of several related fluorinated benzo‐ and acetophenones has been investigated, which allow us to propose a domino‐like fusion mechanism for this unusual transformation. The scope and limitations of the fluorine‐promoted benzophenone fusion are subsequently discussed.
Weakly Coordinating, Ketone‐Directed (η5‐Pentamethylcyclopentadienyl)cobalt(III)‐ and (η5‐Pentamethylcyclopentadienyl)rhodium(III)‐Catalyzed C−H Amidation of Arenes: A Route to Acridone Alkaloids
Authors: Bera Sourav Sekhar , Sk Md Raja , Maji Modhu Sudan 
Published: November 2018

AbstractThe weakly coordinating, ketone‐directed, regioselective monoamidation of aromatic ketones, chalcone, carbazole, and benzophenones was achieved by employing high‐valent cobalt and rhodium catalysis to access numerous biologically important molecular building blocks. This amidation proceeded smoothly with a variety of ketones and several amidating partners. The application of the products in the synthesis of various heterocycles, including acridones, indoles, quinoline, quinolones, quinolinones, and quinazolines, was also explored. The total synthesis of acridone‐based alkaloids, namely, toddaliopsin A, toddaliopsin D, and arborinine, and the formal synthesis of acronycine and noracronycin were also accomplished by applying this method. A mechanistic study revealed this amidation reaction follows a base‐assisted intermolecular electrophilic substitution pathway.
Nonclassical Mechanism in the Cyclodehydration of Diols Catalyzed by a Bifunctional Iridium Complex
Authors: González Miera Greco , Bermejo López Aitor , Martínez‐Castro Elisa , Norrby Per‐Ola , Martín‐Matute Belén 
Published: November 2018

Abstract1,4‐ and 1,5‐diols undergo cyclodehydration upon treatment with cationic N‐heterocyclic carbene (NHC)–IrIIIcomplexes to give tetrahydrofurans and tetrahydropyrans, respectively. The mechanism was investigated, and a metal‐hydride‐driven pathway was proposed for all substrates, except for very electron‐rich ones. This contrasts with the well‐established classical pathways that involve nucleophilic substitution.
Unravelling the Synthesis and Chemistry of Stable, Acyclic, and Double‐Deficient 1,3‐Butadienes: An endo‐Selective Diels–Alder Route to Hedgehog Pathway Inhibitors
Authors: Xin Xiaoyi , Zimmermann Stefan , Flegel Jana , Otte Felix , Knauer Lena , Strohmann Carsten , Ziegler Slava , Kumar Kamal 
Published: November 2018

AbstractThe first synthetic access to stable and acyclic 1,3‐butadienes with two electron‐withdrawing carbonyl groups and their potential to deliver new molecular scaffolds through intriguing endo‐selective Diels–Alder cycloadditions are presented. The bicyclic scaffolds produced through the cycloaddition chemistry of electron‐deficient dienes afforded potent Hedgehog signaling pathway inhibitors.