bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Meta-analysis of the Types and Outcomes of Conservative Excisional Surgery for Recalcitrant or Infected Diabetic Toe Ulcers
Authors: Yammine Kaissar , Assi Chahine 
Published: June 2019

Although they occur frequently, diabetic toe ulcers (DTUs) are poorly investigated. Long-term antibiotics or toe amputation are the usual indications for complicated DTU treatment. Some authors reported good to excellent results following conservative surgery (CS) for recalcitrant or infected wounds; yet no systematic review has been published. Seven studies, comprising 290 patients with 317 ulcers, met the inclusion criteria of this meta-analysis. Three types of CS were found: resection arthroplasty of the interphalangeal joint, toe-sparing bone excision (internal pedal amputation), and distal Symes amputation. The meta-analytical results were as follows: healing rate of 98.3%, healing time of 6.8 ± 3.9 weeks, recurrence rate of 2.3%, wound dehiscence/recurrent infection rate of 6.4%, skin necrosis rate of 2.8%, and revision surgery rate of 7.4%. Subgroup analyses showed no significant differences in outcomes between recalcitrant ulcers and infected ulcers nor between surgery types. Significance was found in relation to ulcer location; when compared with the hallux, DTU on the lesser toes demonstrated better outcomes. Compared with the reported overall results of standard of care associated with antibiotics or toe amputation of complicated DTUs in the literature, CS seems to be a better option for the treatment of recalcitrant or infected DTUs. Levels of Evidence: Level III
Use of Amulet in behavioral change for geriatric obesity management
Authors: Batsis John A , Zagaria Alexandra B , Halter Ryan J , Boateng George G , Proctor Patrick , Bartels Stephen J , Kotz David 
Published: June 2019

Background Obesity in older adults is a significant public health concern. Weight-loss interventions are known to improve physical function but risk the development of sarcopenia. Mobile health devices have the potential to augment existing interventions and, if designed accordingly, could improve one’s physical activity and strength in routine physical activity interventions. Methods and results We present Amulet, a mobile health device that has the capability of engaging patients in physical activity. The purpose of this article is to discuss the development of applications that are tailored to older adults with obesity, with the intention to engage and improve their health. Conclusions Using a team-science approach, Amulet has the potential, as an open-source mobile health device, to tailor activity interventions to older adults.
Radiographic Evaluation of Minimally Invasive Instrumentation and Fusion for Treating Unstable Spinal Column Injuries
Authors: Cavanaugh Daniel , Usmani M. Farooq , Weir Tristan B. , Camacho Jael , Yousaf Imran , Khatri Vishal , Bivona Louis , Shasti Mark , Koh Eugene Y. , Banagan Kelley E. , Ludwig Steven C. , Gelb Daniel E. 
Published: June 2019

Study Design: Retrospective cohort. Objective: Facet fusion in minimally invasive spine surgery (MISS) may reduce morbidity and promote long-term construct stability. The study compares the maintenance of correction of thoracolumbar (TL) trauma patients who underwent MISS with facet fusion (FF) and without facet fusion (WOFF) and evaluates instrumentation loosening and failure. Methods: TL trauma patients who underwent MISS between 2006 and 2013 were identified and stratified into FF and WOFF groups. To evaluate progressive kyphosis and loss of correction, Cobb angles were measured at immediate postoperative, short-term, and long-term follow-up. Evidence of >2 mm of radiolucency on radiographs indicated screw loosening. If instrumentation was removed, postremoval kyphosis angle was obtained. Results: Of the 80 patients, 24 were in FF and 56 were in WOFF group. Between immediate postoperative and short-term follow-up, kyphosis angle changed by 4.0° (standard error [SE] 1.3°) in the FF and by 3.0° (SE 0.4°) in the WOFF group. The change between immediate postoperative and long-term follow-up kyphosis angles was 3.4° (S.E 1.1°) and 5.2° (S.E 1.6°) degrees in the FF and WOFF groups, respectively. Facet fusion had no impact on the change in kyphosis at short term ( P = .49) or long term ( P = .39). The screw loosening rate was 20.5% for the 80 patients with short-term follow-up and 68.8% for the 16 patients with long-term follow-up. There was no difference in screw loosening rate. Fifteen patients underwent instrumentation removal—all from the FF group. Conclusion: FF in MISS does not impact the correction achieved and maintenance of correction in patients with traumatic spine injuries.
Differential expression of Plg-RKT and its effects on migration of proinflammatory monocyte and macrophage subsets
Authors: Thaler Barbara , Baik Nagyung , Hohensinner Philipp J. , Baumgartner Johanna , Panzenböck Adelheid , Stojkovic Stefan , Demyanets Svitlana , Huk Ihor , Rega-Kaun Gersina , Kaun Christoph , Prager Manfred , Fischer Michael B. , Huber Kurt , Speidl Walter S. , Parmer Robert J. , Miles Lindsey A. , Wojta Johann 
Published: June 2019

Abstract
Membrane-bound plasmin is used by immune cells to degrade extracellular matrices, which facilitates migration. The plasminogen receptor Plg-RKT is expressed by immune cells, including monocytes and macrophages. Among monocytes and macrophages, distinct subsets can be distinguished based on cell surface markers and pathophysiological function. We investigated expression of Plg-RKT by monocyte and macrophage subsets and whether potential differential expression might have functional consequences for cell migration. Proinflammatory CD14++CD16+ human monocytes and Ly6Chigh mouse monocytes expressed the highest levels of Plg-RKT and bound significantly more plasminogen compared with the other respective subsets. Proinflammatory human macrophages, generated by polarization with lipopolysaccharide and interferon-γ, showed significantly higher expression of Plg-RKT compared with alternatively activated macrophages, polarized with interleukin-4 and interleukin-13. Directional migration of proinflammatory monocytes was plasmin dependent and was abolished by anti–Plg-RKT monoclonal antibody, ε-amino-caproic acid, aprotinin, and the aminoterminal fragment of urokinase-type plasminogen activator. In an in vivo peritonitis model, significantly less Ly6Chigh monocyte recruitment was observed in Plg-RKT−/− compared with Plg-RKT+/+ mice. Immunohistochemical analysis of human carotid plaques and adipose tissue showed that proinflammatory macrophages also exhibited high levels of Plg-RKT in vivo. Our data demonstrate higher expression of Plg-RKT on proinflammatory monocyte and macrophage subsets that impacts their migratory capacity.
Hotspot origin for asymmetrical conjugate volcanic margins of the austral South Atlantic Ocean as imaged on deeply penetrating seismic reflection lines
Authors: Reuber Kyle , Mann Paul , Pindell Jim 
Published: June 2019

We have interpreted 27,550 km of deep-penetrating, 2D-seismic reflection profiles across the South Atlantic conjugate margins of Uruguay/Southern Brazil and Namibia. These reflection profiles reveal in unprecedented detail the lateral and cross-sectional, asymmetrical distribution of voluminous, postrift volcanic material erupted during the Barremian-Aptian (129–125 Ma) period of early seafloor spreading in the southernmost South Atlantic. Using this seismic grid, we mapped the 10–200 km wide, continental margin-parallel limits of seaward-dipping reflector (SDR) complexes — that are coincident with interpretations from previous workers using seismic refraction data from the South American and West African conjugate margins. Subaerially emplaced and tabular SDRs have rotated downward 20° in the direction of the mid-Atlantic spreading ridge and are up to 22 km thick near the limit of continental crust. The SDR package is wedge shaped and thins abruptly basinward toward the limit of oceanic crust where it transitions to normal, 6–8 km thick oceanic crust. We have developed a model for the conjugate rifted margins that combine diverging tectonic plates and northwesterly plate motion relative to a fixed mantle position of the mantle plume. Our model explains an approximately 30% higher volume of SDRs/igneous crust on the trailing Namibian margin than on the leading Brazilian margin during the syn- and postrift phases. Our model for volcanic margin asymmetry in the South Atlantic does not require a simple shear mechanism to produce the asymmetrical volcanic material distribution observed from our data and from previously published seismic refraction studies. Determining the basinward extent of the extended continental basement is crucial for understanding basin evolution and for hydrocarbon exploration. Although these conjugate margins have evolved asymmetrically, their proximity during the early postrift stage suggests a near-equivalent, early basin evolution and similar hydrocarbon potential. Understanding the tectonic and magnetic processes that produce these observed asymmetries is critical for understanding volcanic passive margin evolution.
Control of Precambrian-to-Paleozoic orogenic trends on along-strike variations in Early Cretaceous continental rifts of the South Atlantic Ocean
Authors: Reuber Kyle , Mann Paul 
Published: June 2019

The Early Cretaceous (135–130 Ma) continental rupture of Western Gondwana to form the South American and African plates closely paralleled the elongate trends of Precambrian and Paleozoic orogenic belts. These orogenic belts were produced as a result of the Neoproterozoic convergent and strike-slip assembly of Gondwana that redeformed during later, Paleozoic orogenic events. Continued continental rifting led to the formation of conjugate, South Atlantic volcanic passive margins whose widths vary from 55 to 180 km. Along-strike variations in crustal stretching, as measured from deep-penetration seismic reflection profiles, correlate with parallel and oblique orientations of rifts relative to the trend of the orogenic, basement fabric. Where orogenic fabric trends parallel to the north–south South Atlantic rift direction such as in the Dom Feliciano orogenic belt of Uruguay and Brazil and the Kaoko Uruguay/Brazil and Kaoko orogenic belt of Namibia, we observe narrow (55–90 km) rift zones with modest continental beta factors of 2.5–3.5 because smaller amounts of rifting were needed to stretch the weaker and parallel, orogenic, basement fabric. Where the basement fabric trends near-orthogonally to the north–south South Atlantic rift direction such as in the Salado suture of Southern Uruguay and the Damara Belt of Namibia, we observe wider (185–220 km) rift zones with higher beta factors of 4.3–5 because greater amounts of stretching were needed to rupture the orthogonal, orogenic, basement fabric. The rift-oblique Gariep Belt intersects the South Atlantic continental rupture at an intermediate angle (30°) and exhibits a predicted intermediate beta factor of 4.0. A compilation of published beta factors from 36 other rifted margins worldwide supports the same basement-trend-degree of stretching relationship that we have developed — with rift-parallel margins having lower beta factors in a range of 1.3–3.5 and rift-orthogonal or oblique margins having higher beta factors in a range of 4–8.
Correlation Between Differentiation of Adrenocortical Zones and Telomere Lengths Measured by Q-FISH
Authors: Nonaka Keisuke , Aida Junko , Takubo Kaiyo , Yamazaki Yuto , Takakuma Shoichiro , Kakizaki Mototsune , Matsuda Yoko , Ishikawa Naoshi , Ishiwata Toshiyuki , Chong Ja-Mun , Arai Tomio , Sasano Hironobu 
Published: June 2019

Abstract

Context
Adrenocortical zonation is associated with a markedly complex developmental process, and the pathogenesis and/or etiology of many disorders of adrenocortical zonal development have remained unknown. Cells from the three adrenocortical zones are morphologically and functionally differentiated, and the mature stage of cell development or senescence has been recently reported to be correlated with telomere length. However, the telomere length of each adrenocortical zonal cell has not yet been studied in human adrenal glands.

Objective
We aimed to study the telomere lengths of adrenocortical parenchymal cells from three different zones of the adrenal glands present during childhood, adolescence, and adulthood.

Methods
Adrenal glands of 30 autopsied subjects, aged between 0 and 68 years, were retrieved from pathology files. The normalized telomere to centromere ratio (NTCR), an index of telomere length, was determined in the parenchymal cells of the zona glomerulosa, zona fasciculata, and zona reticularis (ZR), using quantitative fluorescence in situ hybridization.

Results
NTCR of ZR cells was the longest, followed in decreasing order by that of zona glomerulosa and zona fasciculata cells in subjects aged 20 to 68 years, but no substantial differences in NTCR were detected among these three zones in the group <20 years of age. NTCR of ZR increased with age in subjects aged 20 to 68 years, whereas no important age-dependent changes in NTCR were detected in the group <20 years of age.

Conclusion
The telomere lengths for three zones in adrenal cortex were correlated with their differentiation in adulthood but not in childhood and adolescence.
Bone morphology is regulated modularly by global and regional genetic programs
Authors: Eyal Shai , Kult Shiri , Rubin Sarah , Krief Sharon , Felsenthal Neta , Pineault Kyriel M. , Leshkowitz Dena , Salame Tomer-Meir , Addadi Yoseph , Wellik Deneen M. , Zelzer Elazar 
Published: June 2019

ABSTRACT
Bone protrusions provide stable anchoring sites for ligaments and tendons and define the unique morphology of each long bone. Despite their importance, the mechanism by which superstructures are patterned is unknown. Here, we identify components of the genetic program that control the patterning of Sox9+/Scx+ superstructure progenitors in mouse and show that this program includes both global and regional regulatory modules. Using light-sheet fluorescence microscopy combined with genetic lineage labeling, we mapped the broad contribution of the Sox9+/Scx+ progenitors to the formation of bone superstructures. Then, by combining literature-based evidence, comparative transcriptomic analysis and genetic mouse models, we identified Gli3 as a global regulator of superstructure patterning, whereas Pbx1, Pbx2, Hoxa11 and Hoxd11 act as proximal and distal regulators, respectively. Moreover, by demonstrating a dose-dependent pattern regulation in Gli3 and Pbx1 compound mutations, we show that the global and regional regulatory modules work in a coordinated manner. Collectively, our results provide strong evidence for genetic regulation of superstructure patterning, which further supports the notion that long bone development is a modular process.
This article has an associated ‘The people behind the papers’ interview.
Fully covered self-expandable esophageal metallic stents in patients with inoperable malignant disease who survived for more than 6 months after stent placement
Authors: Bakheet Nader , Park Jung-Hoon , Hu Hong-Tao , Yoon Sung Hwan , Kim Kun Yung , Zhe Wang , Jeon Jae Yong , Song Ho-Young 
Published: June 2019

Objectives:
To investigate the clinical outcomes of fully covered self-expanding metal stent (FCSEMS) placement in patients with malignant esophageal obstruction who survived longer than 6 months.

Methods:
From January 2002 to January 2018, 88 FCSEMS were placed in 64 patients (mean age 62.9 ± 11.6 years; 58 males) with inoperable malignant esophageal obstruction with or without esophago-respiratory fistula. Only patients who survived more than 6 months with FCSEMS in place were included. Data regarding technical and clinical success, complications, reinterventions, stent patency, and patient survival were obtained from a prospectively maintained hospital database.

Results:
The technical and clinical success rates were 100 % (64/64). During follow-up, the median dysphagia score significantly improved (3.09 ± 0.68 to 1.05 ± 0.60, p &lt; 0.001). The complication rate was 48.8 %. Multivariate analysis revealed that only longer stenting duration was associated with complications [hazard ratio = 1.220, 95 % confidence interval (CI) (1.074–2.760), p = 0.039]. The median follow-up duration was 257 days (range, 181–969). The median stent patency duration was 289 days [95% CI (209.9–368.1)]. The median survival was 254 days [95% CI (219.7–288.3)].

Conclusions:
Our data suggest that esophageal FCSEMS placement is an effective option for patients with malignant dysphagia when survival longer than 6 months is expected. The rate of complications increases with time, and SEMS development is needed to keep up with the advancement in oncological treatment.

Advances in knowledge:
Fully covered esophageal self-expandable stent placement is effective in patients surviving more than 6 months, however, the rate of complications also increases.
SEMS development is needed to cope with the advancement in oncological treatment.
PERANCANGAN SISTEM PENGATURAN SUHU CAIRAN DENGAN METODE KONTROL FUZZY PADA DISPENSER KOPI INSTAN OTOMATIS
Authors: Yusuf Yusuf , Triwiyatno Aris , Setiyono Budi 
Published: June 2019

Industri kopi yang semakin berkembang, maka semakin banyak juga teknologi yang dipakai didalamnya. Sudah banyak digunakan berbagai mesin kopi dari yang manual sampai full automatic. Pada mesin kopi automatic yang biasa dijumpai di minimarket masih menggunakan sistem kontrol konvensional sehingga masih memakan banyak waktu dalam prosesnya. Oleh karena itu dibutuhkan suatu sistem pada mesin kopi otomatis untuk mendapatkan hasil yang lebih optimal. Pada penelitian ini merancang sebuah sistem kontrol suhu pada dispenser kopi instan otomatis menggunakan kontrol fuzzy yang dapat menghasilkan respon sistem untuk memenuhi kriteria performansi yang diinginkan. Sistem ini menggunakan dua buah heater masing-masing untuk kopi dan creamer. Proses pengontrolan heater menggunakan modul dimmer yang didalamnya terdapat rangkaian pengendali tegangan AC yang berfungsi untuk mengendalikan tegangan pada masing-masing pemanas. Alat dispenser kopi instan otomatis juga dapat memproses otomasi level menggunakan ball valve. Pengujian sistem pemanas menggunakan kontrol fuzzy yang diberi setpoint berbeda. Setelah dilakukan pengujian, respon sistem yang menghasilkan nilai waktu stabil terkecil adalah sistem yang menggunakan kontrol fuzzy dengan suhu 80oC. Sistem ini dapat memanaskan kopi dan creamer pada suhu awal 30oC dan suhu akhir 80oC . Waktu stabil pada respon sistem ini adalah 514,3 detik . Error pada respon sistem ini adalah 2,2oC suhu akhir.
APLIKASI MEDIA PEMASARAN PROPERTI DENGAN MENGGUNAKAN TEKNOLOGI AUGMENTED REALITY PADA PERANGKAT ANDROID
Authors: Faizin Ahmad Arif , Somantri Maman , Christyono Yuli 
Published: June 2019

Bisnis properti mengalami perkembangan yang pesat setiap tahun, namun media promosi yang digunakan perusahaan masih menggunakan cara yang biasa, seperti menggunakan brosur yang hanya menampilkan gambar 2D saja. Dengan banyaknya kompetitor, konsumen menginginkan sesuatu yang unik dan berbeda untuk mengetahui informasi properti lebih detail dan lebih nyata. Augmented Reality merupakan teknologi yang tepat untuk memenuhi kebutuhan konsumen tersebut. Augmented Reality adalah teknologi yang menggabungkan dunia virtual dalam dunia nyata secara langsung. Oleh karena itu, dirancang sebuah aplikasi yang berfungsi sebagai profil perusahaan sekaligus menampilkan properti 3D dengan menggunakan teknologi Augmented Reality pada perangkat Android. Aplikasi ini dibuat menggunakan Unity3D untuk membuat Augmented Reality dan Android Studio untuk membuat company profile. Perancangan aplikasi menggunakan Unified Modelling Language berupa diagram use case, diagram aktivitas, dan diagram kelas. Hasil pengujian menunjukkan setiap fitur dapat berjalan dengan baik. Objek 3D mulai tampil dengan jarak pendeteksian awal dari 20 cm sampai sekitar 105.9 cm. Sedangkan saat pelacakan, objek 3D masih dapat tampil dari jarak sekitar 6.8 cm sampai sekitar 242.2 cm. Berdasarkan sudutnya, objek 3D mulai tampil dengan sudut pendeteksian awal maksimal sekitar 56.2 derajat. Sedangkan saat pelacakan, objek 3D masih dapat tampil sampai sekitar 87.8 derajat.
OPTIMISASI PENEMPATAN KAPASITOR BANK UNTUK MEREDUKSI RUGI DAYA MENGGUNAKAN FLOWER POLLINATION ALGORITHM PADA JARINGAN AUXILIARY LOAD PT.PJB PEMBANGKITAN INDRAMAYU 3X330 MW
Authors: Wiratsongko Tito , Sukmadi Tejo , Handoko Susatyo 
Published: June 2019

Pada pembangkit listrik, besarnya energi yang diperlukan untuk auxiliary load sendiri berkisar antara 1-10% dari produksi energi yang dihasilkan. Jenis beban pada jaringan auxiliary load di pembangkit listrik kebanyakan adalah berupa motor listrik, seperti: pompa uap pengendali turbin, dan pompa sirkulasi air. Ada kecendrungan faktor daya rendah pada busbar beban di jaringan auxiliary load ( < 0,85), diakibatkan banyak nya konsumsi daya reaktif sehingga mengakibatkan tingginya rugi-rugi daya pada saluran. Pada penelitian ini, dibahas mengenai optimisasi penempatan kapasitor bank untuk mereduksi faktor daya menggunakan FPA. Metode optimasi ini terinspirasi dari proses penyerbukan bunga oleh serangga yang ada di alam semesta. Metode ini akan membangkitakan sekawanan serangga yang tiap-tiap individunya membawa nilai konfigurasi kapasitor yang berbeda satu sama lain. Nilai-nilai inilah yang nantinya akan diselesaikan oleh algoritma metode ini untuk mendapatkan nilai yang paling optimal. Hasil penelitian membuktikan bahwa dengan menempatkan 53 kapasitor dengan total rating 1060 kVAR pada bus 24 , 26, 28, 30, 34, 36, 38, 40, 42, 44, 50, 52, 54, 56, 60, 62, dan 66 mampu menurunkan rugi daya aktif sebesar 22,6 kW dan rugi daya reaktif menurun sebesar 28,1 kVAR sehingga didapatkan penghematan sebesar $12.952,1681dalam kurun waktu 5 tahun.
SIMULASI PENGENDALIAN SHELL HEAVY OIL FRACTIONATOR (SHOF) MENGGUNAKAN METODE KONTROL ADAPTIF
Authors: Martasia Sela , Setiyono Budi , Wahyudi Wahyudi 
Published: June 2019

Shell Heavy Oil Fractionator (SHOF) adalah suatu kolom distilasi atau yang disebut juga fraksinator yang digunakan untuk memisahkan heavy oil mentah menjadi produk-produk yang diinginkan berdasarkan perbedaan titik didih dari masing-masing produk tersebut. Perancangan kendali pada SHOF memiliki beberapa kendala yang disebabkan oleh non-linearitas pada proses, interaksi multivariabel, waktu tunda (dead time) yang panjang, dan gangguan. Berdasarkan hal tersebut, dibutuhkan suatu metode kontrol yang mampu mengendalikan respon sistem untuk pengoptimalan sistem SHOF sehingga keluaran komposisi produk sesuai dengan yang diharapkan. Kontroler tersebut digunakan untuk mengendalikan valve pada kolom fraksinator SHOF dengan tiga masukan dan tiga keluaran yang telah didekopling. Metode kontrol adaptif autotuning umpan balik relay dan algoritma Dahlin merupakan beberapa jenis metode kontrol yang mampu mengendalikan plant multivariabel dengan fungsi alih FOPDT. Berdasarkan pengujian yang telah dilakukan, rata-rata IAE terkecil yang diperoleh pada top end point composition (Y1) tanpa dan dengan gangguan sebesar 21,46 dan 101,78 dengan kontroler autotuning umpan balik relay sedangkan pada side end point composition (Y2) diperoleh rata-rata IAE terkecil tanpa dan dengan gangguan sebesar 9,19 dan 37,66 dengan kontroler autotuning umpan balik relay.
Affine-compact functors
Authors: Gubeladze Joseph 
Published: June 2019

Abstract
Several well known polytopal constructions are examined from the functorial point of view. A naive analogy between the Billera–Sturmfels fiber polytope and the abelian kernel is disproved by an infinite explicit series of polytopes. A correct functorial formula is provided in terms of an affine-compact substitute of the abelian kernel. The dual cokernel object is almost always the natural affine projection. The Mond–Smith–van Straten space of sandwiched simplices, useful in stochastic factorizations, leads to a different kind of affine-compact functors and new challenges in polytope theory.