bluuebunny/crossref_metadata_2025_split huggingface dataset:
Irregular hatching patterns of Branchinecta orientalis G.O. Sars, 1901 (Branchiopoda: Anostraca) in response to parental food, brood order, and pre-inundation conditions
Authors: Pormehr Navid , Van Stappen Gilbert , Agh Naser , Atashbar Behrooz , Beladjal Lynda 
Published: April 2019

ABSTRACT
Highly variable environmental conditions can put the survival of inhabitants of temporary pools at high risk, as they may not complete their life cycle. Different evolutionary responses can prevent the extinction of the inhabitants of ephemeral wetland habitats. One specific mode of response to environmental changes is bet-hedging as risk-spreading strategy and long-term fluctuating selection. The fairy shrimp Branchinecta orientalis G.O. Sars, 1901 is a broadly distributed species in Europe and Asia. We investigated the hatching pattern of B. orientalis resting eggs as a result of various factors, alone or interacting: 1) brood order, 2) food supplied to the parental generation, and 3) various pre-inundation conditions. Results were recorded for cumulative hatching over 10 d, hatching at the first day, and the first day of hatching. The factors with significant effects on hatching percentage were 1) brood order, 2) type of food, 3) pre-inundation conditions, 4) interaction between brood order and type of food, and 5) interaction between type of food and pre-inundation conditions (P < 0.05). Within the first 24 h, 44% of total hatching occurred. Resting eggs from the first brood showed the highest cumulative hatching. The lowest mean resting egg size was found when parents were fed fish pond effluents supplemented with Haematococcus sp. (Chlorophyta); this group of resting eggs also had the highest cumulative hatching percentage. Eggs that had stayed for one week in the parental medium showed significantly higher cumulative hatching percentage, than eggs that had stayed in the medium for two weeks, or that had not stayed in the medium at all (P < 0.05). Overall, hatching showed an irregular pattern, affected by the mode of response of the resting eggs to our experimental factors. The irregular hatching pattern may result in fairy shrimps better adapted to environmental instability.
Where Does ’Ayyē Come From? Proclisis and Affix Pleonasm in the Biblical Hebrew Interrogatives ’Ē and ’Ayyē
Authors: Kantor Benjamin 
Published: April 2019

Abstract
Interrogatives from the base *’ayy- are common throughout Semitic. Two of the reflexes of this base in Biblical Hebrew, ’ē ‘where?’ and ’ayyē ‘where?’, exhibit atypical phonological features. In the case of ’ē (&lt; *’ayy-v), the diphthong *ay ought to have been preserved due to the following gemination (cf. day [&lt; *dayy-v] ‘sufficiency’). In the case of ’ayyē, the final ṣere is unusual. In this paper, I argue that contraction has occurred in ’ē because it is proclitic and that the ṣere (-ē) ending in ’ayyē is from the Semitic adverbial ending *-ay, which also contracted to -ē due to proclisis. The morphosyntactic developments of these forms, taken within their wider Semitic context, shed light on the linguistic phenomenon of ‘affix pleonasm‘ in both Hebrew and Semitic.
Mass functions, luminosity functions, and completeness measurements from clustering redshifts
Authors: Bates Dominic J , Tojeiro Rita , Newman Jeffrey A , Gonzalez-Perez Violeta , Comparat Johan , Schneider Donald P , Lima Marcos , Streblyanska Alina 
Published: April 2019

Abstract
This paper presents stellar mass functions and i-band luminosity functions for Sloan Digital Sky Survey (SDSS) galaxies with i &lt; 21 using clustering redshifts. From these measurements, we also compute targeting completeness measurements for the Baryon Oscillation Spectroscopic Survey (BOSS). Clustering redshifts is a method of obtaining the redshift distribution of a sample of galaxies with only photometric information by measuring the angular cross-correlation with a spectroscopic sample in different redshift bins. We construct a spectroscopic sample containing data from the BOSS + eBOSS surveys, allowing us to recover redshift distributions from photometric data out to z ≃ 2.5. We produce k-corrected i-band luminosity functions and stellar mass functions by applying clustering redshifts to SDSS DR8 galaxies in small bins of colour and magnitude. There is little evolution in the mass function between 0.2 &lt; z &lt; 0.8, implying that the most massive galaxies form most of their mass before z = 0.8. These mass functions are used to produce stellar mass completeness estimates for the BOSS, giving a stellar mass completeness of $80{{\ \rm per\ cent}}$ above M⋆ &gt; 1011.4 between 0.2 &lt; z &lt; 0.7, with completeness falling significantly at redshifts higher than 0.7, and at lower masses. Large photometric data sets will be available in the near future (DECaLS, DES, Euclid), so this and similar techniques will become increasingly useful in order to fully utilize these data.
Altered Localization of Hybrid Incompatibility Proteins in Drosophila
Authors: Cooper Jacob Carter , Lukacs Andrea , Reich Shelley , Schauer Tamas , Imhof Axel , Phadnis Nitin 
Published: April 2019

AbstractUnderstanding the molecular basis of hybrid incompatibilities is a fundamental pursuit in evolutionary genetics. In crosses between Drosophila melanogaster females and Drosophila simulans males, an interaction between at least three genes is necessary for hybrid male lethality: Hmr mel, Lhr sim, and gfzf sim. Although HMR and LHR physically bind each other and function together in a single complex, the connection between gfzf and either of these proteins remains mysterious. Here, we show that GFZF localizes to many regions of the genome in both D. melanogaster and D. simulans, including at telomeric retrotransposon repeats. We find that GFZF localization at telomeres is significantly different between these two species, reflecting the rapid evolution of telomeric retrotransposon copy number composition between the two species. Next, we show that GFZF and HMR normally do not colocalize in D. melanogaster. In interspecies hybrids, however, HMR shows extensive mis-localization to GFZF sites, thus uncovering a new molecular interaction between these hybrid incompatibility factors. We find that spreading of HMR to GFZF sites requires gfzf sim but not Lhr sim, suggesting distinct roles for these factors in the hybrid incompatibility. Finally, we find that overexpression of HMR and LHR within species is sufficient to mis-localize HMR to GFZF binding sites, indicating that HMR has a natural low affinity for GFZF sites. Together, these studies provide the first insights into the different properties of gfzf between D. melanogaster and D. simulans, and uncover a molecular interaction between gfzf and Hmr in the form of altered protein localization.
Depression and change in occupational functioning in type 2 diabetes
Authors: Moulton C D , Murray L , Winkley K , Amiel S A , Ismail K , Patel A 
Published: April 2019

AbstractBackgroundThe effect of depression on both employment and productivity in type 2 diabetes (T2D) is poorly understood.AimsWe tested whether depressive symptoms at diagnosis of T2D are associated with change in employment status and productivity over 2-year follow-up.MethodsIn a prospective analysis of working-age (18–63 years) people with newly diagnosed T2D recruited from primary care, we tested the association between depressive symptoms at diagnosis of T2D (baseline) and employment rates over 2 years. Using the Patient Health Questionnaire-9, depressive symptoms were measured categorically (depression caseness score ≥10) and continuously. In those employed, we measured changes in presenteeism and absenteeism using the World Health Organization (WHO) Health and Work Performance Questionnaire in univariate and multivariate models, respectively, including and excluding part-time workers.ResultsOf 1202 people aged 18–63 at baseline, 982 (82%) provided employment information; the mean age was 50.3 (SD 8.1) years, 44% were female, 59% of non-white ethnicity and 16% had depression. After adjustment for age, sex, ethnicity, socio-economic status, diabetes control and depression treatment, depression caseness was associated with worsening unemployment over 2 years only in full-time workers (odds ratio 0.43 (95% CI 0.20, 0.96), P < 0.05). In those employed full-time or part-time, total depressive symptoms were associated with worsening presenteeism over 2 years after full adjustment (β = −2.63 (95% CI −4.81, −0.45), P < 0.05), despite no association with worsening absenteeism.ConclusionsIn newly diagnosed T2D, depressive symptoms demonstrate an association with worsening employment rate and decline in work productivity over 2-year follow-up.
Spectral properties of gamma-ray bursts observed by the Suzaku wide-band all-sky monitor
Authors: Ohmori Norisuke , Yamaoka Kazutaka , Yamauchi Makoto , Urata Yuji , Ohno Masanori , Sugita Satoshi , Hurley Kevin , Tashiro Makoto S , Fukazawa Yasushi , Iwakiri Wataru , Katsukura Daisuke , Kokubun Motohide , Makishima Kazuo , Murakami Souta , Nakagawa Yujin E , Nakazawa Kazuhiro , Odaka Katsuya , Takahashi Kaito , Takahashi Tadayuki , Terada Yukikatsu 
Published: April 2019

Abstract
We have systematically studied the spectral properties of 302 localized gamma-ray bursts (GRBs) observed by the Suzaku wide-band all-sky monitor (WAM) from 2005 August to 2010 December. The energy spectra in the 100–5000 keV range integrated over the entire emission and the 1 s peak were fitted by three models: a single power law, a power law with an exponential cutoff (CPL), and the GRB Band function (GRB). Most of the burst spectra were well fitted by a single power law. The average photon index α was −2.11 and −1.73 for long and short bursts, respectively. For the CPL and GRB models, the low-energy and high-energy photon indices (α and β) for the entire emission spectra were consistent with previous measurements. The averages of the α and β were −0.90 and −2.65 for long-duration GRBs, while the average α was −0.55 and the β was not well constrained for short-duration GRBs. However, the average peak energy Epeak was 645 and 1286 keV for long- and short-duration GRBs respectively, which are higher than previous Fermi/GBM measurements (285 keV and 736 keV). The α and Epeak of the 1 s peak spectra were larger, i.e., the spectra were harder, than the total fluence spectra. Spectral simulations based on Fermi-GBM results suggest that the higher Epeaks measured by the Suzaku WAM could be due to detector selection bias, mainly caused by the limited energy range above 100 keV.
Self-Disorders in Asperger Syndrome Compared to Schizotypal Disorder: A Clinical Study
Authors: Nilsson Maria , Arnfred Sidse , Carlsson Jessica , Nylander Lena , Pedersen Lennart , Mortensen Erik Lykke , Handest Peter 
Published: April 2019

Abstract

Objective
There are historical and theoretical indications of a difference in subjective experience between autism spectrum disorder (ASD) and the schizophrenia spectrum. However, this difference has not been empirically explored. Therefore, to explore potential differences in subjective experience between the 2 spectra, we examined the presence/absence of self-disorders in Asperger syndrome/autism spectrum disorder (As/ASD) compared to schizotypal disorder (Sd). Self-disorders represent changes in basic self-awareness which have been found to accumulate within the schizophrenia spectrum.

Methods
All participants were recruited from clinical units and interviewed with a focus on the exploration of presence/absence of self-disorders, with the Examination of Anomalous Self-Experience (EASE) scale, and a general assessment of present psychopathology, with Schedules for Clinical Assessment in Neuropsychiatry (SCAN).

Results
A total of 51 participants (As/ASD, n = 22; Sd, n = 29) were included in the statistical analyses. When controlling for age, gender, years of education, mental problems before the age of 16, and special needs school attendance, there was a clear difference in presence/absence of self-disorders between the 2 groups, with significantly higher levels in the Sd group. Further, there was an overlap in SCAN-rated symptoms between the 2 groups.

Conclusion
Our results indicate a significant difference between As/ASD and Sd at the level of the basic self, which, in turn, indicates that an exploration of anomalous self-experience is a valuable supplement in the clinical differentiation between As/ASD and Sd.
Neighborhood Characteristics at Birth and Positive and Negative Psychotic Symptoms in Adolescence: Findings From the ALSPAC Birth Cohort
Authors: Solmi Francesca , Lewis Glyn , Zammit Stanley , Kirkbride James B 
Published: April 2019

Abstract

Background
Urban birth is associated with risk of non-affective psychoses, but the association with subclinical positive and negative symptoms is less clear, despite emerging evidence. Further the extent to which these findings are confounded by polygenic risk scores (PRS) for schizophrenia is also unknown.

Methods
Using data from the Avon Longitudinal Study of Parents and Children, linked to census geographical indicators, we examined whether various indices of urbanicity at birth were associated with negative and positive psychotic symptoms at age 16 and 18 years, respectively. We used logistic regression models, controlling for child’s ethnicity, maternal age, education, marital status, social class, depressive symptoms, other neighborhood exposures, and, in a subsample of children of white ethnicity (N = 10 283), PRS for schizophrenia.

Results
Amongst 11 879 adolescents, those born in the most densely populated tertile had greater odds of reporting positive psychotic experiences, after multivariable adjustment (odds ratio [OR]: 1.57, 95% confidence intervals (CIs): 1.14–2.17). Adolescents born in the most socially fragmented neighborhoods had greater odds of negative symptoms, after multivariable adjustment (OR: 1.43, 95% CI: 1.06–1.85). Although we found that greater schizophrenia PRS were associated with an increased risk of being born in more deprived and fragmented (bot not more densely populated areas), these associations were not confounded by PRS.

Interpretation
Birth into more densely populated and socially fragmented environments increased risk of positive and negative psychotic phenomena in adolescence, respectively, suggesting that different forms of neighborhood social adversity may impinge on different psychopathophysiologies associated with the clinical expression of psychosis.
Co-producing European knowledge and publics amidst controversy: The EU expert network on unconventional hydrocarbons
Authors: Lis Aleksandra , Kama Kärg , Reins Leonie 
Published: April 2019

AbstractTo date, social sciences have devoted little attention to the processes of expert knowledge production related to the exploitation of unconventional hydrocarbon resources. In this article, we examine an epistemic experiment led by the European Commission, the European Science and Technology Network on Unconventional Hydrocarbon Extraction, which was aimed at producing authoritative knowledge claims on shale energy development. By developing the idiom of ‘co-production’, the article provides a more fine-grained understanding of the processes through which competing knowledge claims, forms of epistemic authority, and new energy publics co-evolve in a situation of highly-politicized controversy. Drawing on our first-hand observations as participants representing the social sciences in the expert network, this article provides an in-depth ethnographic account of the struggles of the European Union authorities to manage and delimit the controversy. In this way, the analysis develops our understanding of the challenges in improving the deliberation of shale gas as a transnational energy policy issue.
Visual experience drives sleep need in Drosophila
Authors: Kirszenblat Leonie , Yaun Rebecca , van Swinderen Bruno 
Published: April 2019

Abstract
Sleep optimizes waking behavior, however, waking experience may also influence sleep. We used the fruit fly Drosophila melanogaster to investigate the relationship between visual experience and sleep in wild-type and mutant flies. We found that the classical visual mutant, optomotor-blind (omb), which has undeveloped horizontal system/vertical system (HS/VS) motion-processing cells and are defective in motion and visual salience perception, showed dramatically reduced and less consolidated sleep compared to wild-type flies. In contrast, optogenetic activation of the HS/VS motion-processing neurons in wild-type flies led to an increase in sleep following the activation, suggesting an increase in sleep pressure. Surprisingly, exposing wild-type flies to repetitive motion stimuli for extended periods did not increase sleep pressure. However, we observed that exposing flies to more complex image sequences from a movie led to more consolidated sleep, particularly when images were randomly shuffled through time. Our results suggest that specific forms of visual experience that involve motion circuits and complex, nonrepetitive imagery, drive sleep need in Drosophila.
Assessment of cognitive profile as a prodromal marker of the evolution of rapid eye movement sleep behavior disorder
Authors: Terzaghi Michele , Toscano Gianpaolo , Casoni Francesca , Picascia Marta , Arnaldi Dario , Rustioni Valter , Versino Maurizio , Sinforiani Elena , Manni Raffaele 
Published: April 2019

Abstract

Study Objectives
To search for a specific neuropsychological profile in idiopathic REM sleep behavior disorder (iRBD), able to predict the onset of neurodegenerative disorders.

Methods
In a longitudinal follow-up study of 63 consecutive iRBD patients (follow-up duration 6.7 ± 3.8 years), the baseline cognitive profile of converters to neurodegenerative disease was compared with that of the nonconverters. Five cognitive domains were assessed: memory, attention-working memory, executive functions, visuospatial abilities, language. Mild cognitive impairment (MCI) was diagnosed according to the Movement Disorder Society’s diagnostic criteria for Parkinson’s disease.

Results
30 subjects (47.6%) developed a neurodegenerative disease (latency to conversion 60.33 ± 44.81 months). MCI was found in 50% of the converters and 12% of the nonconverters (p = .001), and its presence conferred a neurodegenerative disease risk of 10% at 3 years, 36% at 5 years, and 73% at 10 years (p = .002). Pathological equivalent scores on at least one neuropsychological test were detected in 46.7% of the converters versus 21.2% of the nonconverters in the memory domain (p = .032), in 40.0% versus 6.1% in that of executive functions (p = .002), and in 20.0% versus 3% in the visuospatial abilities domain (p = .047). On multivariate analysis, impaired executive functions significantly correlated with phenoconversion (p = .018). Lower Mini Mental State Examination (MMSE) scores (p = .004) and memory deficits (p = .031) were found in patients who developed dementia first.

Conclusions
Cognitive profile is useful for stratifying risk of phenoconversion in patients with iRBD. The presence of MCI and impaired executive functions, memory, and visuospatial abilities discriminated the converters. Lower MMSE scores and memory deficits may characterize those subjects who first develop dementia.
A Taxonomy of Child Policies: Conceptualizing the Missing Step in Defamilization of Social Policy
Authors: Palme Joakim , Heimer Maria 
Published: April 2019

AbstractThe UN Convention on the Rights of the Child has created momentum for the notion of child policy to be advanced. The article elaborates a taxonomy of child policies for analyzing policy instruments aimed at promoting various aspects of children’s welfare, and four different types of child policies are identified. The article explores the feasibility of this conceptual framework with a case study of Sweden. We frame the move toward child-centered policies in terms of defamilization: such policies may enhance “freedom as non-domination” and could be seen as the second round of the defamilization of social policy.
ModelTest-NG: a new and scalable tool for the selection of DNA and protein evolutionary models
Authors: Darriba Diego , Posada David. , Kozlov Alexey M. , Stamatakis Alexandros , Morel Benoit , Flouri Tomas 
Published: April 2019

AbstractModelTest-NG is a re-implementation from scratch of jModelTest and ProtTest, two popular tools for selecting the best-fit nucleotide and amino acid substitution models, respectively. ModelTest-NG is one to two orders of magnitude faster than jModelTest and ProtTest but equally accurate, and introduces several new features, such as ascertainment bias correction, mixture and FreeRate models, or the automatic processing of partitioned datasets. ModelTest-NG is available under a GNU GPL3 license at https://github.com/ddarriba/modeltest.
Toward A Reproducible, Scalable Framework for Processing Large Neuroimaging Datasets
Authors: Johnson Erik C. , Wilt Miller , Rodriguez Luis M. , Norman-Tenazas Raphael , Rivera Corban , Drenkow Nathan , Kleissas Dean , LaGrow Theodore J. , Cowley Hannah , Downs Joseph , Matelsky Jordan , Hughes Marisa , Reilly Elizabeth , Wester Brock , Dyer Eva , Kording Konrad , Gray-Roncal William 
Published: April 2019

ABSTRACTEmerging neuroimaging datasets (collected through modalities such as Electron Microscopy, Calcium Imaging, or X-ray Microtomography) describe the location and properties of neurons and their connections at unprecedented scale, promising new ways of understanding the brain. These modern imaging techniques used to interrogate the brain can quickly accumulate gigabytes to petabytes of structural brain imaging data. Unfortunately, many neuroscience laboratories lack the computational expertise or resources to work with datasets of this size: computer vision tools are often not portable or scalable, and there is considerable difficulty in reproducing results or extending methods. We developed an ecosystem of neuroimaging data analysis pipelines that utilize open source algorithms to create standardized modules and end-to-end optimized approaches. As exemplars we apply our tools to estimate synapse-level connectomes from electron microscopy data and cell distributions from X-ray microtomography data. To facilitate scientific discovery, we propose a generalized processing framework, that connects and extends existing open-source projects to provide large-scale data storage, reproducible algorithms, and workflow execution engines. Our accessible methods and pipelines demonstrate that approaches across multiple neuroimaging experiments can be standardized and applied to diverse datasets. The techniques developed are demonstrated on neuroimaging datasets, but may be applied to similar problems in other domains.
Resistance to aztreonam in combination with non-β-lactam β-lactamase inhibitors due to the layering of mechanisms in Escherichia coli identified following mixed culture selection
Authors: Cheung Ching Hei Phoebe , Dulyayangkul Punyawee , Heesom Kate J. , Avison Matthew B. 
Published: April 2019

AbstractUsing mixed culture selection, we show how reduced envelope permeability, reduced target-site affinity, and increased β-lactamase production layer to confer aztreonam/β-lactamase inhibitor resistance in Escherichia coli. We report a clinical isolate producing CTX-M-15 and CMY-4, lacking OmpF, and carrying a PBP3 mutation. It is resistant to aztreonam plus the inhibitors avibactam, relebactam and vaborbactam. Mobilisation of blaSHV-12 into this isolate generated a derivative additionally resistant to aztreonam plus the bicyclic boronate inhibitors 2 and taniborbactam.