bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of the owner-manager of small tourism businesses on the success of internet marketing
Authors: Elliott R. , Boshoff C. 
Published: July 2019

Small businesses have been identified as a catalyst for creating jobs and generally growing the economy. One industry that is characterised by the proliferation of small businesses is the tourism industry. Key to this industry reaching its full potential is, however, access to markets. The Internet is seen by many as having the potential to help small tourism businesses understand their markets better, extend their market reach and to serve their customers more effectively, irrespective of their geographical location. However, identifying the factors that influence the success of the use of the Internet for marketing purposes is proving elusive.The focus of this study is to identify those owner-manager factors that are present in a small tourism business which will influence the success with which the Internet can be used to market the business. These are distinct from the factors implicit in the technology per se. If these owner-manager factors can be identified and their relative influence on Internet marketing success is determined, it will allow small tourist businesses to access markets more readily.The results of this study indicate that the level of involvement of owner-managers, the owner-manager having an entrepreneurial orientation, the knowledge of owner-managers, the involvement in decision making of owner-managers and a marketing orientation are important to the successful use of the Internet for the marketing of small tourism businesses in South Africa.
Maxillary metastasis from carcinoma lung:
An unusual presentation
Authors: Bisht Niharika , Singh Sankalp , Sarin Arti , Mulajker Deepak , Gupta Samir , Mishra Prabha Shankar 
Published: July 2019

Abstract
Lung cancer is one of the most common
cancers in the world affecting both men and woman.
Common site of metastasis includes liver,
adrenals, bone, and brain. Metastasis to the
maxilla is very rare with only a few cases being
reported so far. Here, we present a case of a
32-year-old male where metastatic lesion was
discovered before primary tumor.
A evasão aparente entre engenharias sob a ótica da análise de redes sociais
Authors: Miranda Júnior Newton da Silva , Cabello Andrea Felippe , Hoffmann Valmir Emil 
Published: July 2019

Embora muito se ressaltem as altas taxas de deserção acadêmica nos cursos de engenharia, as evasões aparentes pouco são evidenciadas, mesmo sendo parte do fenômeno. Dessa forma, o presente estudo aborda a evasão aparente entre habilitações da grande área de conhecimento das engenharias por meio da Análise de Redes Sociais - ARS. Como objetivo geral, descreveu-se essa rede por meio das métricas de densidade e grau de centralidade, analisando-se o fluxo migratório dos 259 casos de transferências internas de alunos entre as 15 habilitações de engenharia, no período de 2012 a 2016, na Universidade de Brasília. Entre os resultados, a rede densa e os rumos dos fluxos migratórios entre os cursos sugerem uma propensão de o aluno de engenharia apenas mudar de habilitação entre as possíveis na instituição, permanecendo na área. As engenharias mecânica, elétrica e produção despontaram como as mais buscadas. Por outro lado, engenharias criadas mais recentemente na instituição tenderam a perder alunos dentro da rede. As evidências do estudo permitiram concluir que o aluno, embora incerto quanto à habilitação, possuiu a área de conhecimento como certa.
&lt;sup&gt;10&lt;/sup&gt;Be-based exploration of the timing of deglaciation in two selected areas of southern Norway
Authors: Marr Philipp , Winkler Stefan , Binnie Steven A. , Löffler Jörg 
Published: July 2019

Abstract. We present new 10Be surface exposure ages from two selected
locations in southern Norway. A total of five 10Be samples allow a first
assessment of local deglaciation dynamics of the Scandinavian Ice Sheet at
Dalsnibba (1476 m a.s.l.) in southwestern Norway. The bedrock ages from the
summit of Dalsnibba range from 13.3±0.6 to 12.7±0.5 ka
and probably indicate the onset of deglaciation as a glacially transported
boulder age (16.5±0.6 ka) from the same elevation likely shows
inheritance. These ages indicate initial deglaciation commencing at the end
of the Bølling–Allerød interstadial (∼ 14.7–12.9 kyr BP)
and ice-free conditions at Dalsnibba's summit during the Younger Dryas.
Bedrock samples at lower elevations imply vertical ice surface lowering down
to 1334 m a.s.l. at 10.3±0.5 ka and a longer overall period of
downwasting than previously assumed. Two further 10Be samples add to
the existing chronology at Blåhø (1617 m a.s.l.) in south-central Norway. The 10Be erratic boulder sample on the summit of Blåhø
sample yields 20.9±0.8 ka, whereas a 10Be age of 46.4±1.7 ka for exposed summit bedrock predates the Late Weichselian Maximum.
This anomalously old bedrock age infers inherited cosmogenic nuclide
concentrations and suggests low erosive cold-based ice cover during the Last Glacial Maximum.
However, due to possible effects of cryoturbation and frost heave processes
affecting the erratic boulder age and insufficient numbers of 10Be
samples, the glaciation history on Blåhø cannot conclusively be
resolved. Comparing the different timing of deglaciation at both locations
in a rather short west–east distance demonstrates the complex dynamics of
deglaciation in relation to other areas in southern Norway.
En toch is het prachtig werk: weerbaarheid bij forensisch sociale professionals
Authors: de Vogel Vivienne , Bosker Jacqueline 
Published: July 2019

Enhancing resilience in forensic social professionals
Working in the forensic social field is interesting and fulfilling and many professionals deliberately choose to do this work. However, it can also be a very demanding job. Experiencing aggressive incidents by forensic clients, continuous tensions in contact with clients and the confrontation with narratives about shocking events are specific characteristics of working in the forensic field that appeal to the resilience of professionals. This article discusses which characteristics of organisations, teams and individual professionals impact on resilience and how it can be enhanced.
Hører du overhovedet efter? En undersøgelse af talerens mimik i en situation med manglende respons
Authors: Junge Tanja Alexandra 
Published: July 2019

Denne artikel stiller skarpt på taleres mimik i en situation hvor de udsættes for ikke aktiv lytning. Fire deltagere fortæller en personlig historie til en modtager der ikke reagerer på det, der bliver sagt. Ved hjælp af konversationsanalytisk metode og forskning indenfor gestik, vises det hvordan deltagerne, via mimiske ressourcer, forsøger at opnå forståelse eller reaktion hos en modtager der ikke responderer, og hvordan det påvirker fortællingen, når denne respons udebliver. Et centralt fund er, at ansigtet fungerer som en understregelse af stemmens, blikkets og gestikkens responssøgende funktion. Analysen viser også at deltagere aktivt opsøger øjenkontakt i vigtige passager, men at det gensidige blik alene, ikke opfattes som tilstrækkeligt bevis på, at deres ytring er blevet hørt eller forstået.
Exercer son rôle stratégique dans les organisations pluralistes : le cas des cadres intermédiaires du réseau de la santé1,2
Authors: Côté Nancy , Denis Jean-Louis 
Published: July 2019

Cet article porte sur le rôle stratégique des cadres intermédiaires dans les organisations pluralistes du secteur de la santé. Il vise à rendre compte de la complexité de leur travail stratégique en période de changements. L’analyse a permis d’établir trois attributs dustrategizing3, c’est-à-dire des activités qui sont influencés par la nature imposée ou participative du changement : 1) la création d’un réseau d’alliances; 2) la négociation des valeurs; et 3) les micro pratiques quotidiennes.
Aider les décideurs à franchir le cap de l’international : apport de la théorie de l’effectuation sur le lien barrières, opportunités et décision d’internationalisation
Authors: Ricard Antonin , Aldebert Bénédicte 
Published: July 2019

Cet article cherche à évaluer l’impact du mode de raisonnement des décideurs (causal ou effectual) sur leur comportement en contexte d’internationalisation. Nos résultats, basés sur un échantillon de 148 décideurs de PME françaises, révèlent que les décideurs effectuaux ont tendance à saisir les opportunités d’internationalisation plus vite que les causaux (1); que les décideurs causaux sont plus enclins à internationaliser leur firme suivant un processus séquentiel et progressif (2); qu’en situation d’internationalisation de leur firme, les décideurs causaux sont davantage freinés par des barrières internes que les décideurs effectuaux (3) et que le mode de raisonnement (effectual ou causal) n’a pas d’incidence sur les comportements en présence de barrières externes (4).
Les bibliothèques au coeur de la transformation sociale
Authors: Lachal Jérémy 
Published: July 2019

Dans le contexte d’un monde globalisé et toujours plus connecté, les inégalités se creusent : les plus vulnérables sont enfermés dans un cercle vicieux au sein duquel le déficit d’accès et de maîtrise des usages de l’information les empêche de développer les compétences et de saisir les opportunités qui pourraient leur permettre de sortir de la pauvreté.
À cet égard, l’information, l’éducation et la culture doivent aujourd’hui être communément acceptées comme les leviers de prévention des vulnérabilités et d’émancipation, et les bibliothèques entendues à la fois comme des lieux de développement pour les individus et des espaces citoyens de création du lien social.
Les bibliothèques, qui offrent un accès gratuit aux contenus, à la connectivité et à l’interaction sociale, et les bibliothécaires, avec leur expertise méthodologique, l’orientation thématique qu’ils peuvent fournir et leur connaissance de l’écosystème local, apparaissent comme des ressources merveilleuses pour promouvoir l’innovation et se muer en incubateur de projets à impact social. Cela doit passer aussi bien par la proposition de contenus de qualité, contextualisés et en libre accès que par le développement des compétences numériques des citoyens ; à défaut, nous irons irrévocablement vers une augmentation des inégalités et une marginalisation accrue des populations les plus vulnérables.
Identification of significant gene and pathways involved in HBV-related hepatocellular carcinoma by bioinformatics analysis
Authors: Xie Shucai , Jiang Xili , Zhang Jianquan , Xie Shaowei , Hua Yongyong , Wang Rui , Yang Yijun 
Published: July 2019

Background
Hepatocellular carcinoma (HCC) is a common malignant tumor affecting the digestive system and causes serious financial burden worldwide. Hepatitis B virus (HBV) is the main causative agent of HCC in China. The present study aimed to investigate the potential mechanisms underlying HBV-related HCC and to identify core biomarkers by integrated bioinformatics analyses.

Methods
In the present study, HBV-related HCC GSE19665, GSE55092, GSE94660 and GSE121248 expression profiles were downloaded from the Gene Expression Omnibus database. These databases contain data for 299 samples, including 145 HBV-related HCC tissues and 154 non-cancerous tissues (from patients with chronic hepatitis B). The differentially expressed genes (DEGs) from each dataset were integrated and analyzed using the RobustRankAggreg (RRA) method and R software, and the integrated DEGs were identified. Subsequently, the gene ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed using the DAVID online tool, and the protein–protein interaction (PPI) network was constructed using STRING and visualized using Cytoscape software. Finally, hub genes were identified, and the cBioPortal online platform was used to analyze the association between the expression of hub genes and prognosis in HCC.

Results
First, 341 DEGs (117 upregulated and 224 downregulated) were identified from the four datasets. Next, GO analysis showed that the upregulated genes were mainly involved in cell cycle, mitotic spindle, and adenosine triphosphate binding. The majority of the downregulated genes were involved in oxidation reduction, extracellular region, and electron carrier activity. Signaling pathway analysis showed that the integrated DEGs shared common pathways in retinol metabolism, drug metabolism, tryptophan metabolism, caffeine metabolism, and metabolism of xenobiotics by cytochrome P450. The integrated DEG PPI network complex comprised 288 nodes, and two important modules with high degree were detected using the MCODE plug-in. The top ten hub genes identified from the PPI network were SHCBP1, FOXM1, KIF4A, ANLN, KIF15, KIF18A, FANCI, NEK2, ECT2, and RAD51AP1. Finally, survival analysis revealed that patients with HCC showing altered ANLN and KIF18A expression profiles showed worse disease-free survival. Nonetheless, patients with FOXM1, NEK2, RAD51AP1, ANLN, and KIF18A alterations showed worse overall survival.

Conclusions
The present study identified key genes and pathways involved in HBV-related HCC, which improved our understanding of the mechanisms underlying the development and recurrence of HCC and identified candidate targets for the diagnosis and treatment of HBV-related HCC.
Physico-chemical, Gas Chromatography-Mass Spectrometry (GC-MS) Analysis and Cold Saponification of Wild Grapes (Lannea microcarpa Engl & K. Krause) Seed Oil
Authors: Warra Aliyu Ahmad , Mohammed Hadiza Ibrahim , Morayo Adejuwon Olorunsola 
Published: July 2019

Aims: Physico-chemical, Gas Chromatography-Mass Spectrometry (GC-MS) and Cold saponification was carried out on Lannea microcarpa (Wild grape) seed oil with the aim of identifying the quality and quantity of the oil and its suitability in soap production.
Study Design: Experimental and instrumental study was done to determine the physicochemical characteristics, fatty acids present in the seed oil and its suitability for soap production.
Place and Duration of Study: The study was conducted at the Biochemistry Laboratory, Kebbi State University of Science and Technology, Aliero, Nigeria from May to June, 2014.
Methodology: The hexane extract of the sample was obtained by complete extraction using Soxhlet extractor, physicochemical analysis was carried out. A gas chromatography coupled with mass spectroscopy detector (GC-MS) system was used for the qualitative fatty acid determination. Simple cold method saponification was used in producing the soap.
Results: The powdered seed (50 g) yielded 59.21±0.01% of the oil. Results from the physicochemical analysis showed the seed oil to be dark purple in colour and partially soluble in water with the acid, iodine, saponification and peroxide values at 16± 0.01 mgKOH/g, 121.6±0.1 gI2/100 g, 231.25±0.02 mgKOH/g, 3.02±0.01 meq H2O2respectively. The relative density and refractive index of the oil are at 0.5983±0.0001 (g/cm3) and 1.43±0.01 respectively. Qualitative GC-MS revealed the following fatty acids; Decanoic acid, Palmitic acid, Stearic acid, Margaric acid, 1-octadecanoic acid, Oleic and Erucic acid. The soap produced from the seed oil has pH and Foam height, 10.18±0.01 and 105.1±0.1 (cm³) respectively.
Conclusion: The present study on seeds of wild grape revealed that the oil is a viable natural product that can be utilized in thefood and cosmetic industry.
Growth and Extracellular Enzyme Activity Responses of a Multi-enzymic Strain of Serratia sp. in a Simulated Diesel-contaminated System
Authors: Asitok Atim , Antai Sylvester , Ekpenyong Maurice 
Published: July 2019

Aim: The present study was aimed at elucidating the alternative metabolic preferences of Serratia sp. strain DW2 that permitted its survival in a diesel-contaminated environment.
Study Design: We adopted a 4 x 4 x 3 completely randomized design of a full-factorial experiment for the study.
Place and Duration of Study: The study was conducted at the Department of Microbiology, University of Calabar, Nigeria, during the months of March and June, 2019.
Methodology: In this study, Serratia sp. strain DW2 was isolated from Douglas Creek water of the Qua Iboe Estuary, along the Qua Iboe terminal at Ibeno, Nigeria, as a significant biological contributor to the decontamination process through inherent ability to utilize diesel oil hydrocarbons. This paper elucidated the growth and responses of the bacterial lipase, caseinase and gelatinase activities to diesel-oil hydrocarbon contamination.
Results: Range finding test results showed that the bacterium could grow in the presence of water soluble fraction of diesel (wsf-D) concentration between .0042 and .0335 µg/mL, albeit with increasing lag time and decreasing specific growth rate when compared with growth in glucose-Bushnell-Haas broth. Lag time changes were not significantly influenced by exposure time but changes in specific growth rate were. Gelatinase activity was most susceptible to toxicant onslaught but was least affected by exposure time. Conversely, lipase activity was the most affected by exposure time. Toxicant concentration/exposure time interaction of a two-way analysis of variance model for caseinase activity was not significant (P > .05) but those for lipase and gelatinase activities were.
Conclusion: The bacterium survived diesel toxicity by exploiting its lipase and gelatinase activities for provision of alternative sources of carbon, energy and nitrogen to drive ecosystem decontamination in the event of refined petroleum contamination.
RAS and BRAF mutations in cell‐free DNA are predictive for outcome of cetuximab monotherapy in patients with tissue‐tested RAS wild‐type advanced colorectal cancer
Authors: van Helden Erik J. , Angus Lindsay , Menke‐van der Houven van Oordt C. Willemien , Heideman Daniëlle A. M. , Boon Eline , van Es Suzanne C. , Radema Sandra A. , van Herpen Carla M. L. , de Groot Derk Jan A. , de Vries Elisabeth G. E. , Jansen Maurice P. H. M. , Sleijfer Stefan , Verheul Henk M. W. 
Published: July 2019

In metastatic colorectal cancer, RAS and BRAF mutations cause resistance to anti‐EGFR therapies, such as cetuximab. Heterogeneity in RAS and BRAF mutations might explain nonresponse in a subset of patients receiving cetuximab. Analyzing mutations in plasma‐derived circulating tumor DNA (ctDNA) could provide a more comprehensive overview of the mutational landscape as compared to analyses of primary and/or metastatic tumor tissue. Therefore, this prospective multicenter study followed 34 patients with metastatic colorectal cancer who were tissue‐tested as RAS wild‐type (exons 2–4) during routine work‐up and received third‐line cetuximab monotherapy. BRAF mutation status was also tested but did not exclude patients from therapy. At baseline and upon disease progression, cell‐free DNA (cfDNA) was isolated for targeted next‐generation sequencing (NGS). At 8 weeks, we determined that patients had benefited from treatment. NGS of cfDNA identified three patients with RAS mutations not detected in tumor tissue during routine work‐up. Another six patients had a BRAF or rare RAS mutation in ctDNA and/or tumor tissue. Relative to patients without mutations in RAS/BRAF, patients with mutations at baseline had shorter progression‐free survival [1.8 versus 4.9 months (P < 0.001)] and overall survival [3.1 versus 9.4 months (P = 0.001)]. In patients with clinical benefit (progressive disease after 8 weeks), ctDNA testing revealed previously undetected mutations in RAS/BRAF (71%) and EGFR (47%), which often emerged polyclonally. Our results indicate that baseline NGS of ctDNA can identify additional RAS mutation carriers, which could improve patient selection for anti‐EGFR therapies. Acquired resistance, in patients with initial treatment benefit, is mainly explained by polyclonal emergence of RAS, BRAF, and EGFR mutations in ctDNA.
Factors Associated With Participation in Rheumatic Disease–Related Research Among Underrepresented Populations: A Qualitative Systematic Review
Authors: Lima Kaitlin , Phillip Courtnie R. , Williams Jessica , Peterson Jonna , Feldman Candace H. , Ramsey-Goldman Rosalind 
Published: July 2019

ObjectiveNonwhite racial/ethnic groups remain underrepresented in rheumatic disease–related research, despite being disproportionately affected by these disorders. Our objective was to systematically review the literature regarding underrepresented patients’ perceptions of participation in rheumatic disease research and to develop strategies to improve diversity.MethodsA systematic search of Embase, PubMed/Medline, PsycINFO, and Cochrane was performed through October 2018. Two independent reviewers identified 642 unique studies; 7 met inclusion criteria (peer‐reviewed articles, published in English in the last 20 years, adult population, and with a focus on underrepresented patients’ participation in rheumatic research). Five coauthors provided final approval of included articles. Data abstraction was performed, and common themes and key differences were determined and adjudicated.ResultsThe 7 articles included (n = 1,892 patients, range per article 20–961) evaluated factors associated with research participation of underrepresented populations. Five articles were related to lupus and 2 to rheumatoid arthritis, and 5 focused on African American patients and 1 on Hispanic patients. Five of the studies provided quantitative data through surveys (n = 3) and chart review (n = 2), while 2 used qualitative analyses. Key themes regarding underrepresented patients’ perceptions of participating in research included: 1) the importance of trust in the patient– physician relationship, 2) the understanding of heterogeneity within and between ethnic groups, 3) the need for authentic academic‐community partnerships, and 4) the implications of strict inclusion criteria on study participant diversity.ConclusionLimited evidence exists regarding underrepresented patients’ attitudes toward research participation in rheumatology, and further investigation is warranted. The themes identified provide a starting point for future interventions that promote increased diversity in rheumatic disease–related research studies.
Muscle and joint function in children living with arthrogryposis multiplex congenita: A scoping review
Authors: Gagnon Marianne , Caporuscio Kevin , Veilleux Louis‐Nicolas , Hamdy Reggie , Dahan‐Oliel Noémi 
Published: July 2019

AbstractArthrogryposis multiplex congenita (AMC) is characterized by congenital joint contractures present in two or more body areas. Lack of fetal movement is the underlying cause of AMC, which can lead to abnormal connective tissue surrounding the joint resulting in stiffness and muscle atrophy. Treatment aims at improving function and mobility through surgical and/or conservative interventions. A scoping review was conducted to explore the existing knowledge of the evaluation and treatment of muscle and joint function in children with AMC. Three search engines were included and identified 1,271 articles. Eighty‐seven studies met the selection criteria and were included in this review. All included studies focused on joints, 30 of which also assessed the muscle. Assessment most often included the position of the contractures (n = 72), as well as range of motion (n = 66). Interventions to improve muscle and joint function were reported in 82 of the 87 papers and included surgery (n = 70) and conservative interventions (n = 74) with bony surgery (i.e., osteotomy) the most common surgery and rehabilitation the most common conservative intervention. Recurrences of contractures were mentioned in 46 of the 68 studies providing a follow‐up. Future studies should use validated measures to assess muscle and joint function, and conservative interventions should be described in greater detail and to include a longer follow‐up.