bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective role of luteolin against bisphenol A‐induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO‐1 pathway
Authors: Alekhya Sita Gadamsetty Jaya , Gowthami Motati , Srikanth Gadiparthi , Krishna M. Murali , Rama Sireesha Kokkiligadda , Sajjarao Mounika , Nagarjuna Kandru , Nagarjuna Mukkamulla , Chinnaboina Gopala Krishna , Mishra Anurag , SreeHarsha Nagaraja 
Published: May 2019

AbstractFor the development of renal diseases, oxidative stress (OS) is reasoned to be one of the risk factors. For the treatment or prevention of the renal disease, the use of antioxidants could be a hopeful therapeutic mediation as they retard or block the oxidative reaction along with the inflammatory process. Luteolin (Lut) is a plant flavonoid, a pharmacologically active component normally found in glycosylated forms in basic perilla leaf, green pepper, celery, seed, honeysuckle bloom, and chamomile blossom; it exhibits antioxidant activity. In this investigation, we explored the nephroprotective activity of Lut on bisphenol A (BPA)‐induced nephron toxicity in rats. Orally administering Lut (100 and 200 mg/kg) diminished BPA‐induced anomalies in the kidney, blood urea nitrogen, creatinine, and serum uric acid levels. Lut therapy reduced the BPA‐influenced generation of inflammatory mediators, inclusive of tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta. This was coupled with significant improvement in kidney histopathologic features. Lut enhanced the nuclear factor‐like 2 (Nrf2) and heme oxygenase 1 (HO‐1) expression, which showed protection against OS induced by BPA. The current outcomes of the study showed that Lut has a strong reactive oxygen species scavenging property and potentially decreases the lipid peroxidation as well as inhibits DNA damage in renal toxicity induced by BPA. In conclusion, the potential antioxidant effect of Lut may be because of its modulatory effect on the Nrf2/antioxidant response element (ARE)/HO‐1 pathway, which means it protects the kidney from BPA‐induced oxidative injury. © 2019 IUBMB Life, 2019
Cell‐surface‐bound circulating DNA in the blood: Biology and clinical application
Authors: Tamkovich Svetlana , Laktionov Pavel 
Published: May 2019

AbstractCell‐surface‐bound extracellular DNA (csbDNA) is present on the outer membrane of blood cells, including both red blood cells and leukocytes. Although less well characterized than cell‐free DNA (cfDNA) in plasma and serum, leukocyte and red blood cell csbDNA form a considerable fraction of the blood extracellular nucleic acids pool, with typically at least comparable amount of DNA occurring bound to the outer surface of cells as compared with circulating free DNA in plasma. The cellular origin of csbDNA is not clear; however, as with cfDNA, in patients with cancer a proportion is derived from the tumor, thus making it potentially a useful source of DNA for cancer diagnosis, prognosis, and monitoring. © 2019 IUBMB Life, 71(9):1201–1210, 2019
Trabecular architecture in the humeral metaphyses of non‐avian reptiles (Crocodylia, Squamata and Testudines): Lifestyle, allometry and phylogeny
Authors: Plasse Martial , Amson Eli , Bardin Jérémie , Grimal Quentin , Germain Damien 
Published: May 2019

AbstractThe lifestyle of extinct tetrapods is often difficult to assess when clear morphological adaptations such as swimming paddles are absent. According to the hypothesis of bone functional adaptation, the architecture of trabecular bone adapts sensitively to physiological loadings. Previous studies have already shown a clear relation between trabecular architecture and locomotor behavior, mainly in mammals and birds. However, a link between trabecular architecture and lifestyle has rarely been examined. Here, we analyzed trabecular architecture of different clades of reptiles characterized by a wide range of lifestyles (aquatic, amphibious, generalist terrestrial, fossorial, and climbing). Humeri of squamates, turtles, and crocodylians have been scanned with microcomputed tomography. We selected spherical volumes of interest centered in the proximal metaphyses and measured trabecular spacing, thickness and number, degree of anisotropy, average branch length, bone volume fraction, bone surface density, and connectivity density. Only bone volume fraction showed a significant phylogenetic signal and its significant difference between squamates and other reptiles could be linked to their physiologies. We found negative allometric relationships for trabecular thickness and spacing, positive allometries for connectivity density and trabecular number and no dependence with size for degree of anisotropy and bone volume fraction. The different lifestyles are well separated in the morphological space using linear discriminant analyses, but a cross‐validation procedure indicated a limited predictive ability of the model. The trabecular bone anisotropy has shown a gradient in turtles and in squamates: higher values in amphibious than terrestrial taxa. These allometric scalings, previously emphasized in mammals and birds, seem to be valid for all amniotes. Discriminant analysis has offered, to some extent, a distinction of lifestyles, which however remains difficult to strictly discriminate. Trabecular architecture seems to be a promising tool to infer lifestyle of extinct tetrapods, especially those involved in the terrestrialization.
2019 HRS/EHRA/APHRS/LAHRS focused update to 2015 expert consensus statement on optimal implantable cardioverter‐defibrillator programming and testing
Authors: Stiles Martin K. , Fauchier Laurent , Morillo Carlos A. , Wilkoff Bruce L. 
Published: May 2019

AbstractThe 2015 HRS/EHRA/APHRS/SOLAECE Expert Consensus Statement on Optimal Implantable Cardioverter‐Defibrillator Programming and Testing provided guidance on bradycardia programming, tachycardia detection, tachycardia therapy, and defibrillation testing for implantable cardioverter‐defibrillator (ICD) patient treatment. The 32 recommendations represented the consensus opinion of the writing group, graded by Class of Recommendation and Level of Evidence. In addition, Appendix B provided manufacturer‐specific translations of these recommendations into clinical practice consistent with the recommendations within the parent document. In some instances, programming guided by quality evidence gained from studies performed in devices from some manufacturers was translated such that this programming was approximated in another manufacturer's ICD programming settings. The authors found that the data, although not formally tested, were strong, consistent, and generalizable beyond the specific manufacturer and model of ICD. As expected, because these recommendations represented strategic choices to balance risks, there have been reports in which adverse outcomes were documented with ICDs programmed to Appendix B recommendations. The recommendations have been reviewed and updated to minimize such adverse events. Notably, patients who do not receive unnecessary ICD therapy are not aware of being spared potential harm, whereas patients in whom their ICD failed to treat life‐threatening arrhythmias have their event recorded in detail. The revised recommendations employ the principle that the randomized trials and large registry data should guide programming more than anecdotal evidence. These recommendations should not replace the opinion of the treating physician who has considered the patient's clinical status and desired outcome via a shared clinical decision‐making process.
The research of transgenic human nucleus pulposus cell transplantation in the treatment of lumbar disc degeneration
Authors: Wang Hua‐Cong , Jin Cang‐Hai , Kong Jie , Yu Tao , Guo Jian‐Wei , Hu You‐Gu , Liu Yong 
Published: May 2019

AbstractThe present study determines whether the in vivo injection of TGFβ1 and CTGF mediated by AAV2 to transfect nucleus pulposus cells in degenerative lumbar discs can reverse the biological effects of rhesus lumbar disc degeneration. A total of 42 lumbar discs obtained from six rhesus monkeys were classified into three groups: experimental group, control group, and blank group. Degenerative lumbar discs were respectively injected with double gene‐transfected human nucleus pulposus cells using minimally invasive techniques. Immumohistochemical staining, RT‐PCR, and western blot were performed to observe the biological effects of double gene‐transfected human nucleus pulposus cells in degenerative lumbar discs on rhesus lumbar disc degeneration. At 4, 8, and 12 weeks after the transplantation of nucleus pulposus cells, the expression levels of TGF‐ß1, CTGF, proteoglycan mRNA, and type‐II collagen were detected by RT‐PCR. The values of immumohistochemical staining and RT‐PCR in the experimental group increased at 8 weeks, decreased with time at 12 weeks, and remained greater than the values in the control group, and the differences were statistically significant (P < .05). The western blot revealed that the values in the experimental group decreased with time, but remained greater than those in the PBS control group and blank control group, and the differences were statistically significant (P < .05). The double gene‐transfection of human nucleus pulposus cells in degenerative lumbar discs mediated by rAAV2 can be continuously expressed in vivo after transplantation in lumbar discs of rhesus monkeys, and promotes the synthesis of proteoglycan and type II collagen, achieving the treatment purpose.
The rising rate of nonsmokers among laryngeal carcinoma patients: Are we facing a new disease?
Authors: Shoffel‐Havakuk Hagit , O'Dell Karla , Johns Michael M. , Reder Lindsay , Popova Margarita , Halperin Doron , Feldberg Edit , Lahav Yonatan 
Published: May 2019

Objectives/HypothesisLaryngeal squamous cell carcinoma (SCC) is strongly associated with tobacco smoking. With the rising awareness of tobacco's adverse health effects, we have witnessed a global decrease in tobacco use. Nevertheless, laryngeal SCC remains prevalent and includes a subset of patients lacking the traditional risk factors.Study DesignA two‐center retrospective cohort.MethodsMedical records of patients diagnosed with laryngeal SCC between 2009 and 2016 were reviewed. Data collected included demographics, smoking status, and tumor site. Patients who have never smoked were designated as nonsmokers.ResultsThe study included 330 patients with laryngeal SCC, of whom 75 (22.7%) were nonsmokers; this rate was relatively similar for each of the two institutions independently (21.9% and 25%). There were 285 patients with glottic SCC and 45 with supraglottic SCC. All nonsmoking patients in this cohort had glottic SCC, representing 26.3% (75/285) of the glottic SCC cases. The rate of female patients was significantly higher among nonsmokers. Of the patients with glottic SCC, females represented 25.3% (19/75) of the nonsmokers compared with 12.4% (26/210) of the smokers (P = .008). Mean age at diagnosis was 60.2 ± 17.5 years for nonsmoking glottic SCC patients and 63.6 ± 12.4 years for smokers (P = .280). However, nonsmokers demonstrated a distinct age distribution pattern. Nonsmoking females with glottic SCC demonstrated a bimodal age distribution pattern; 73.7% (14/19) were age <40 years or >75 years at diagnosis.ConclusionsThe rate of laryngeal SCC in nonsmokers is higher than what has previously been reported, representing a growing proportion, and may suggest a shift in etiology. Knowing that laryngeal SCC in nonsmokers predominantly affects the glottis, and that females and age extremities are more vulnerable, the traditional screening paradigm should be revised.Level of Evidence4Laryngoscope, 130:E108–E115, 2020
Incorporation of Very Insoluble Monomers in Waterborne Coatings
Authors: Boscán Freddy , Meeuwisse Marcel , Mestach Dirk , Paulis Maria , Barandiaran Maria Jesus , Bohórquez Silfredo Javier 
Published: May 2019

AbstractThe benefits of polymerizing very insoluble monomers in aqueous media, avoiding the use of energy‐intensive procedures, by implementing two novel synthesis techniques based on the emulsifier combination in emulsion polymerization and on miniemulsification by phase inversion temperature are investigated. The performance of standalone polymers consisting of monomers, namely lauryl methacrylate, isobornyl acrylate, and 1H,1H,2H,2H‐perfluorodecyl acrylate, and of formulated binders with these monomers incorporated either through blending or in situ polymerization, is evaluated with special emphasis on their water‐barrier properties (e.g., uptake, whitening, immersion, and vapor resistance) and on their chemical resistance. The performance of the standalone polymers is found to be similar to that of polymers prepared by high‐shear miniemulsion polymerization, while the performance of the formulated binders is generally superior to a commercial coating formulation based on a binder recommended for water resistance.
Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade
Authors: Marras Connie , Canning Colleen G. , Goldman Samuel M. 
Published: May 2019

AbstractThere is evidence from observational studies for a role of a number of environmental exposures and lifestyle habits in modulating the risk for Parkinson's disease. Environmental and lifestyle associations, if causal, represent opportunities for Parkinson's disease prevention or disease modification at individual and population levels. In the past decade, additional evidence has been published that improves causal inference and/or enhances our understanding of the complexity of these associations. A number of gene–environment interactions have been elucidated, and our understanding of the roles of physical activity, pesticide and other chemical exposures, dietary habits, emotional stress, head injury, and smoking has been refined. In the next decade, better techniques will help us to close the gaps in our knowledge, including taking into account Parkinson's disease heterogeneity and gene and risk factor interactions in observational studies. To do this, larger datasets, global consortia, genomewide environment interaction studies, prospective studies throughout the lifespan, and improvements in the methodology of clinical trials of physical activity will be key. Despite the caveats of observational studies, a number of low‐risk and potentially high‐yield recommendations for lifestyle modification could be made to minimize the individual and societal burdens of Parkinson's disease, including dietary modifications, increasing physical activity, and head injury avoidance. Furthermore, a reduction in pesticide use could have a major impact on global health related to and beyond Parkinson's disease. Given the increasing prevalence of this disorder, formulating and promoting these recommendations should be a high priority. © 2019 International Parkinson and Movement Disorder Society
Strip Spawning Methodology for Captive Propagation of Broadcast-Spawning Cyprinids in the Great Plains
Authors: Urbanczyk Aaron C , Woodley Christa M , Wilde Gene R 
Published: May 2019

Abstract
In the summer of 2011, large parts of Texas and Oklahoma experienced their worst drought in recorded history. Most of the rivers and streams in this region are inhabited by cyprinids that broadcast semibuoyant pelagic ova. These fish depend on flowing water for the hormonal cues that induce spawning and to allow ova to develop and hatch as they float downstream. During the drought, the Brazos and Canadian rivers, Texas, were reduced to isolated streambed pools. Monitoring efforts concluded that pelagic, broadcast-spawning cyprinids experienced complete reproductive failure in the Brazos River and had very little spawning success in the Canadian River. Personnel from the Texas Parks and Wildlife Department, U.S. Fish and Wildlife Service, and Texas Tech University began salvage operations in both rivers in September 2011 to ensure the survival of imperiled cyprinids. In spring 2012, standard captive propagation techniques were used with several species of cyprinids, with little success. As a result, we developed new techniques for four species of pelagic, broadcast-spawning cyprinids from the Brazos and Canadian rivers that could greatly increase hatchery program efficacy.
Magnetic resonance imaging as an assessment tool following intervention with an AdVance XP suburethral sling for postprostatectomy urinary incontinence
Authors: Collado Serra Argimiro , Pelechano Gómez Paula , Martin Isabel , Dominguez‐Escrig Jose , Alberich‐Bayarri Ángel , Barrios María , Cervera Deval José , Rubio‐Briones José 
Published: May 2019

AbstractAimsThe aim of this study was to compare magnetic resonance imaging (MRI) parameters in patients with mild incontinence after radical prostatectomy, who had undergone treatment with a suburethral sling. The objective was to compare patients who had been successfully treated with unsuccessful patients.MethodsThis observational cohort study at a single institution evaluated consecutive patients treated with an AdVance XP sling. MRI was performed using a 1.5 Tesla system. Preoperative urodynamic assessment and flexible cystoscopy were performed. The qualitative analysis was based on sling indentation (complete vs incomplete). The quantitative analysis comprised the following three parameters: the sling‐pubis distance, the thickness of the proximal urethral bulb, and the sling backward distance (SBD), defined as the distance between the prolongation of a line through the major axis of the pubis (the line‐segment joining the vertices of the pubis) and the sling indentation. The primary outcome was pad count at 3 months; cure as zero pads. A logistic univariate regression model was employed to assess the potential predictors of successful outcomes. An adjusted multivariate logistic regression model using the significant univariate factors was developed.ResultsOf the 83 patients enrolled, the univariate analysis revealed a relationship between failure and adverse urodynamics and between success and sling indentation, thickness of the proximal bulb and SBD. Only the association with SBD persisted in the multivariate analysis.ConclusionsMRI revealed a strong relationship between proper positioning of the sling (small SBD) and continence outcome. These data have important implications for a second surgery following initial sling failure.
Ylide‐Functionalization via Metalated Ylides: Synthesis and Structural Properties
Authors: Schwarz Christopher , Scherpf Thorsten , Rodstein Ilja , Weismann Julia , Feichtner Kai‐Stephan , Gessner Viktoria H. 
Published: May 2019

AbstractThe α‐metallated ylides [Ph3P−C−Z]−M+ (with Z=SO2Tol or CN and M=Na or K) were used as versatile nucleophiles for the facile access to ylide‐substituted compounds. Halogenations, alkylations, carbonylations and functionalization reactions with main group element halides were easily accomplished by simple trapping reactions with the appropriate electrophiles. X‐ray crystallographic studies of all compounds – including the first structures of α‐fluorinated P‐ylides – showed remarkable differences in the ylide backbone depending on the substituents. In the fluorinated compounds, a change from a fully planar to a pyramidalized ylidic carbon centre was observed despite the strongly anion‐stabilizing ability of the yldiide substituent. π‐Donation from the ylide substituent also resulted in geometric restrictions depending on the steric and electronic properties of the introduced substituents.
New Energetic Complex of Copper(II) Dinitramide Based Nitrogen‐rich Ligand Aminoguanidine(CH6N4): Synthesis, Structural and Energetic Properties
Authors: Nosratzadegan Keyvan , Mahdavi Mohammad , Ghani Kamal , Barati Kazem 
Published: May 2019

AbstractThe crystal structure of the energetic complex bis(aminoguanidine)copper(II) dinitramide [Cu(AG)2][DN]2 (I), has been determined at 298 K using single‐crystal X‐ray diffraction technique. The Cu(II) atom is four‐coordinated by two imine N atoms and two amine N atoms from two aminoguanidine ligands, forming a slightly distorted square‐planar coordination. In the crystal structure, molecules are linked through intermolecular N−H…O hydrogen bonds, forming a network. The infrared spectrum showed a sharp peaks at 1650 and 1010 cm−1 which are typical of the conjugated C=N stretching due to the coordination of the imine nitrogen and NNN stretching dinitramide counterion, respectively. The thermal decomposition process of this complex was investigated through differential scanning calorimetry (DSC) and the sensitivities toward impact and friction were assessed using a BAM drophammer and a BAM friction tester. In the measurement of I a violent explosion appeared destroying the setup. This may be a reason, due to the copper complex (I), which crystallizes water free. The power of powder and single crystal of I was measured by the Trauzl test are 425 and 427 cm−3 for 10 g I (142 % TNT and 88 % RDX).
The Alphasat Aldo Paraboni scientific and communication experiments at Ka and Q/V bands in Austria
Authors: Cuervo Felix , Martellucci Antonio , Rivera Castro Juan , Schmidt Michael , Schönhuber Michael 
Published: May 2019

SummaryThe use of higher frequencies for satellite multimedia communication systems calls for research of the atmospheric propagation effects at these bands (rain, cloud and gaseous attenuation, scintillation, and depolarization). Alphasat was successfully launched on 25 July 2013. This largest and most powerful European telecommunication satellite carries, besides a commercial payload belonging to the mobile satellite communication provider Inmarsat, several Technology Demonstration Payloads (TDPs) from ESA. One of them is the Aldo Paraboni payload (TDP5) for Q/V‐band communication and Ka/Q‐band propagation experiments. These experiments explore future applications in satellite communication and measure how the Earth's atmosphere affects the propagation of electromagnetic waves. Under ESA contract, JOANNEUM RESEARCH designed, developed, and operates a Q/V‐band communication ground station and a Ka/Q‐band propagation terminal. The experimental site is equipped with ancillary equipment including a multifrequency radiometer profiler, a 2D video disdrometer (2DVD), and meteorological stations. This paper reports on the experimental setup, data processing, and obtained results.
Recent Progress in Advanced Characterization Methods for Silicon‐Based Lithium‐Ion Batteries
Authors: Wu Jingkun , Ma Fei , Liu Xiaorui , Fan Xiayue , Shen Long , Wu Zhihong , Ding Xiaoyang , Han Xiaopeng , Deng Yida , Hu Wenbin , Zhong Cheng 
Published: May 2019

AbstractWith the remarkably large theoretical specific capacity of silicon (Si), Si‐based rechargeable lithium‐ion batteries (LIBs) have attracted great interest, as they are expected to meet the growing demand for large‐scale energy storage devices, electric vehicles, and portable electronic devices with high energy density. However, the Si‐based LIB faces great challenges due to the cyclic volume changes induced by Si, which lead to considerable capacity fading. To facilitate the use of high‐performance LIBs enabled by Si‐based anodes, understanding the fading mechanism is necessary. In this regard, various advanced characterization methods have been developed to reveal the fading mechanism and to develop a modification strategy associated with compositional and structural evolution. In this review, the general understanding of the fading mechanism and the technical specifications of Si‐based LIBs are discussed. The recent progress in advanced characterization methods for Si‐based LIBs is summarized with respect to the achievements in compositional and structural interpretation. Several possible future research directions for Si‐based LIBs and the expected development trends in relevant characterization methods are also discussed.