bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relational Mechanisms in Complex Contracting: Factors Associated with Private Managers’ Satisfaction with and Commitment to the Contract Relationship
Authors: Chuang Emmeline , McBeath Bowen , Carnochan Sarah , Austin Michael J 
Published: July 2019

AbstractThe complexity of human service delivery means that contracts are often incomplete or contingent. When contracted services or products are complex, relational contracting can function as a critical informal accountability mechanism. This study introduces and tests a conceptual framework of relational processes and organizational factors hypothesized to inform private human service contract outcomes. Data from a 2015 survey of private nonprofit and for-profit human service organizations in five counties are used to examine factors associated with two proximal indicators of success in human service contracting: commitment to and satisfaction with the contract relationship. Findings provide support for our conceptual framework, highlight the multidimensional nature of trust and commitment, and identify key differences in the relational processes associated with commitment and satisfaction to the contract relationship. Communication quality, trust, and flexibility were associated with satisfaction, whereas interdependence, flexibility, and asset specificity were associated with longer-term commitment to the contract relationship. For-profit ownership was associated with lower commitment and satisfaction. Implications for research and practice are discussed.
Cooling flow solutions for the circumgalactic medium
Authors: Stern Jonathan , Fielding Drummond , Faucher-Giguère Claude-André , Quataert Eliot 
Published: July 2019

ABSTRACT
In several models of galaxy formation feedback occurs in cycles or mainly at high redshift. At times and in regions where feedback heating is ineffective, hot gas in the galaxy halo is expected to form a cooling flow, where the gas advects inward on a cooling timescale. Cooling flow solutions can thus be used as a benchmark for observations and simulations to constrain the timing and extent of feedback heating. Using analytic calculations and idealized 3D hydrodynamic simulations, we show that for a given halo mass and cooling function, steady-state cooling flows form a single-parameter family of solutions, while initially hydrostatic gaseous haloes converge on one of these solutions within a cooling time. The solution is thus fully determined once either the mass inflow rate ${\dot{M}}$ or the total halo gas mass are known. In the Milky Way halo, a cooling flow with ${\dot{M}}$ equal to the star formation rate predicts a ratio of the cooling time to the free-fall time of ∼10, similar to some feedback-regulated models. This solution also correctly predicts observed $\rm{O\,{\small VII}}$ and $\rm{O\,{\small VIII}}$ absorption columns, and the gas density profile implied by $\rm{O\,{\small VII}}$ and $\rm{O\,{\small VIII}}$ emission. These results suggest ongoing heating by feedback may be negligible in the inner Milky-Way halo. Extending similar solutions out to the cooling radius however underpredicts observed $\rm{O\,{\small VI}}$ columns around the Milky-Way and around other low-redshift star-forming galaxies. This can be reconciled with the successes of the cooling flow model with either a mechanism which preferentially heats the $\rm{O\,{\small VI}}$-bearing outer halo, or alternatively if $\rm{O\,{\small VI}}$ traces cool photoionized gas beyond the accretion shock. We also demonstrate that the entropy profiles of some of the most relaxed clusters are reasonably well described by a cooling flow solution.
Super-Eddington growth of black holes in the early universe: effects of disc radiation spectra
Authors: Takeo Eishun , Inayoshi Kohei , Ohsuga Ken , Takahashi Hiroyuki R , Mineshige Shin 
Published: July 2019

AbstractWe investigate the properties of accretion flows on to a black hole (BH) with a mass of MBH embedded in an initially uniform gas cloud with a density of n∞ in order to study rapid growth of BHs in the early Universe. In previous work, the conditions required for super-Eddington accretion from outside the Bondi radius were studied by assuming that radiation produced at the vicinity of the central BH has a single power-law spectrum ν−α at $h\nu \ge 13.6\, {\rm eV}$ (α ∼ 1.5). However, radiation spectra surely depend on the BH mass and accretion rate, and determine the efficiency of radiative feedback. Here, we perform two-dimensional multifrequency radiation hydrodynamical simulations taking into account more realistic radiation spectra associated with the properties of nuclear accretion discs. We find that the critical density of gas surrounding the BH, above which transitions to super-Eddington accretion occur, is alleviated for a wide range of masses of seed BHs (10 ≲ MBH/M⊙ ≲ 106) because photoionization for accretion disc spectra are less efficient than those for single power-law spectra with 1 ≲ α ≲ 3. For disc spectra, the transition to super-Eddington is more likely to occur for lower BH masses because the radiation spectra become too hard to ionize the gas. Even when accretion flows are exposed to anisotropic radiation, the effect due to radiation spectra shrinks the ionized region and likely leads to the transition to a wholly neutral accretion phase. Finally, by generalizing our simulation results, we construct a new analytical criterion required for super-Eddington accretion; $(M_{\rm BH}/10^5\, {\rm M}_\odot) (n_{\infty }/10^4\, {\rm cm}^{-3}) \gtrsim 2.4 (\langle \epsilon \rangle /100\, {\rm eV})^{-5/9}$, where 〈ϵ〉 is the mean energy of ionizing radiation from the central BH.
A model for the minimum mass of bound stellar clusters and its dependence on the galactic environment
Authors: Trujillo-Gomez Sebastian , Reina-Campos Marta , Kruijssen J M Diederik 
Published: July 2019

ABSTRACT
We present a simple physical model for the minimum mass of bound stellar clusters as a function of the galactic environment. The model evaluates which parts of a hierarchically clustered star-forming region remain bound given the time-scales for gravitational collapse, star formation, and stellar feedback. We predict the initial cluster mass functions (ICMFs) for a variety of galaxies and we show that these predictions are consistent with observations of the solar neighbourhood and nearby galaxies, including the Large Magellanic Cloud and M31. In these galaxies, the low minimum cluster mass of ∼102 M⊙ is caused by sampling statistics, representing the lowest mass at which massive (feedback-generating) stars are expected to form. At the high gas density and shear found in the Milky Way’s Central Molecular Zone and the nucleus of M82, the model predicts that a mass >102 M⊙ must collapse into a single cluster prior to feedback-driven dispersal, resulting in narrow ICMFs with elevated characteristic masses. We find that the minimum cluster mass is a sensitive probe of star formation physics due to its steep dependence on the star formation efficiency per free-fall time. Finally, we provide predictions for globular cluster (GC) populations, finding a narrow ICMF for dwarf galaxy progenitors at high redshift, which can explain the high specific frequency of GCs at low metallicities observed in Local Group dwarfs like Fornax and WLM. The predicted ICMFs in high-redshift galaxies constitute a critical test of the model, ideally suited for the upcoming generation of telescopes.
Single-phase multiferroics: new materials, phenomena, and physics
Authors: Lu Chengliang , Wu Menghao , Lin Lin , Liu Jun-Ming 
Published: July 2019

Abstract
Multiferroics, where multiple ferroic orders coexist and are intimately coupled, promise novel applications in conceptually new devices on one hand, and on the other hand provide fascinating physics that is distinctly different from the physics of high-TC superconductors and colossal magnetoresistance manganites. In this mini-review, we highlight the recent progress of single-phase multiferroics in the exploration of new materials, efficient roadmaps for functionality enhancement, new phenomena beyond magnetoelectric coupling, and underlying novel physics. In the meantime, a slightly more detailed description is given of several multiferroics with ferrimagnetic orders and double-layered perovskite structure and also of recently emerging 2D multiferroics. Some emergent phenomena such as topological vortex domain structure, non-reciprocal response, and hybrid mechanisms for multiferroicity engineering and magnetoelectric coupling in various types of multiferroics will be briefly reviewed.
Reduction of Opioid Use by Acupuncture in Patients Undergoing Hematopoietic Stem Cell Transplantation: Secondary Analysis of a Randomized, Sham-Controlled Trial
Authors: Deng Gary , Giralt Sergio , Chung David J , Landau Heather , Siman Jonathan , Li Qing S , Lapen Kaitlyn , Mao Jun J 
Published: July 2019

AbstractObjectiveTo evaluate acupuncture as a nonpharmacologic intervention for pain management in patients undergoing hematopoietic stem cell transplantation (HSCT).MethodsAdult patients with multiple myeloma undergoing high-dose melphalan chemotherapy and autologous peripheral blood HSCT were randomized to receive either true (TA) or sham acupuncture (SA) once daily for five days starting on the day after chemotherapy. Use of pain medications and pain scores were assessed at baseline and at days 5, 15, and 30 after transplantation.ResultsAmong 60 evaluable subjects, the SA group (vs TA) had greater than five times odds of increasing pain medication use from baseline. Among patients who were opioid nonusers at baseline, all 15 patients in the TA group remained free from opioid use at the end of the study. In contrast, 20% of those in the SA group (four of the 20 patients) started to use opioids after chemotherapy and stem cell infusion (day 5) and 40% (eight of the 20) had become opioid users by day 30 after HSCT (Fisher exact test P = 0.006). Among patients who were taking opioids at baseline, 14% in the TA group vs 10% in the SA group increased opioid intake at day 5, and 21% (TA) vs 30% (SA) at day 30 (P = 0.86).ConclusionsAcupuncture appears to significantly reduce the need for pain medications during HSCT and the number of post-HSCT opioid users among baseline opioid nonusers. It warrants further studies as an opioid-sparing intervention for pain in HSCT patients.
What is Global Expressivism?
Authors: Simpson Matthew 
Published: July 2019

Abstract
Global expressivism is the radical view that we should never think of any of our language and thought as representing the world. While interesting, global expressivism has not yet been clearly formulated, and its defenders often use unexplained terms of art to characterise their view. I fix this problem by carefully and clearly exploring the different ways in which we can interpret globalism. I reject almost all of them either because they are implausible or because they are bad interpretations of actual globalist views. I then argue that the most promising version of globalism, which we can find in the work of Huw Price, turns out to be completely compatible with the view of so-called ‘local’ expressivists. The debate between globalists and localists is therefore empty: the real interest in this topic lies not in this debate but in whether globalism is true and if so what follows from it.
Reliability and Validity of Ratings of Perceived Difficulty During Performance of Static Standing Balance Exercises
Authors: Alsubaie Saud F , Whitney Susan L , Furman Joseph M , Marchetti Gregory F , Sienko Kathleen H , Klatt Brooke N , Sparto Patrick J 
Published: July 2019

Abstract

Background
Standardized instruments for measuring the intensity of balance exercises in clinical environments are lacking.

Objective
The objective of this study was to develop a method for quantifying the perceived intensity of standing balance exercises.

Design
A test-retest study design was used, with repeated evaluations within the same visit and between visits 1 week later.

Methods
Sixty-two participants who were healthy and 18 to 85 years old (with a mean age of 55 years [SD = 20 years]; 50% women) were enrolled. On each of 2 visits, they performed 2 sets of 24 randomized static standing exercises consisting of combinations of the following factors: surface, vision, stance, and head movement. Postural sway was measured with an inertial measurement unit, and ratings of perceived difficulty (RPD) were recorded using numerical and qualitative scales. The RPD scales were validated against the quantitative sway measures using a general linear model approach. The test-retest reliability of the RPD scales was examined using a weighted kappa coefficient.

Results
Both RPD scales were associated with postural sway measures with correlation coefficients &gt; 0.6 for the whole sample. The test-retest reliability of the ratings varied considerably across the different balance exercises, and the highest weighted kappa values occurred for RPD scores on the numerical scale within the second visit, as moderate agreement was achieved in 18 of the 24 exercises.

Limitations
The limitations are that the RPD scales need to be validated for other types of balance exercises and in individuals with balance disorders.

Conclusions
The RPD scores correlated with the magnitude of postural sway, suggesting that they can be used as a proxy measure of perceived intensity of balance exercises.
Giant epidermoid cyst of the spleen in a pediatric patient
Authors: Esposito Susanna , Leonardi Alberto , Penta Laura , Prestipino Marco , Bertozzi Mirko 
Published: July 2019

Abstract

Rationale:
Splenic cysts (SCs) are rare findings in children, particularly the youngest. Here, we discuss a case that is useful for the differential diagnosis and treatment of SCs.

Patient concerns:
A 9-year-old Albanian boy was admitted for severe abdominal pain localized mainly in the left hypochondrium for approximately 24 hours. His medical history was without significant clinical problems.

Diagnosis:
Splenomegaly was diagnosed during the first clinical examination, and laboratory tests showed an increase in CA 125 and CA19-9. Abdominal ultrasonography showed splenomegaly with a large hypoechoic oval formation with well-defined margins and the presence of internal fine suspension spots; abdominal magnetic resonance imaging revealed a well-defined SC. The cystic lesion caused major effects on the neighboring organs, shifting them from their normal sites.

Interventions:
Considering the mass's volume, an open splenectomy was performed. Upon histopathological examination, the lesion was characterized by a stratified squamous keratinized thick lining and brownish liquid contents consisting of lymphocytes, erythrocytes, and hemosiderin-rich macrophages. These features informed the diagnosis of a giant epidermoid SC.

Outcomes:
No complications occurred in the post-operative period, and blood exams revealed the quick normalization of CA 19.9 and CA 125 levels. The boy was discharged on the eighth post-operative day. No complaints were documented during the regular follow-up.

Lessons:
This case shows that modern imaging techniques are useful for the differential diagnosis between epithelial mass and SCs of different origins. Open splenectomy has been the treatment of choice for years, but future studies should clarify whether more conservative methods are associated with positive long-term outcomes and if they can also be used for large SCs.
The risk factors of shunt-dependent hydrocephalus after subarachnoid space hemorrhage of intracranial aneurysms
Authors: Hao Xu , Wei Ding 
Published: July 2019

Abstract
Shunt-dependent hydrocephalus is a common complication of aneurysmal subarachnoid hemorrhage (aSAH) which indicated intensive care unit stay and unfavorable outcome. Our aim is to study the risk factors of shunt-dependent hydrocephalus after aneurysmal subarachnoid space hemorrhage. Patients with intracranial aneurysms treated in our department from January 2014 to October 2018 were included in the study. Patients’ age, gender, history of hypertension and diabetes, location of aneurysms, Glasgow coma scale (GCS) score, Hunt–Hess grading, intraventricular hemorrhage, therapeutic option, shunt placement, clinical outcome, length of stay were analyzed. The follow-up period was 1 to 5 years. Statistics included Chi-squared, Student t test, 1-way analysis of variance, Pearson correlation coefficient, and multivariate logistic regression. About 845 cases with intracranial aneurysms treated in our department were included in the study. The mean age was 52.19 ± 9.51 years and the sex ratio was 317/528. About 14.3% (121/845) of the patients developed shunt-dependent hydrocephalus in the follow-up period. According to our results, older than 60, Hunt–Hess grading, GCS, coma, posterior circulation aneurysm, external ventricular drainage, and decompress craniotomy were risk factors of shunt dependency (P < .05). Moreover, older than 60, GCS 3 to 8, Hunt–Hess 3 to 5, and posterior circulation aneurysm were the independent risk factors of shunt dependency. Moreover, shunt dependency was related to longer hospital stay and unfavorable outcome (P < .05). In conclusion, patients older than 60, GCS 3 to 8, Hunt–Hess 3 to 5, and posterior circulation aneurysm need more strict observation and longer follow-up. Timely and appropriate treatment may benefit patients in recovery, while further exploration is still needed in the future.
Microcirculation function assessed by adenosine triphosphate stress myocardial contrast echocardiography and prognosis in patients with nonobstructive coronary artery disease
Authors: Yang Ning , Su Ya-Fen , Li Wei-Wei , Wang Shan-Shan , Zhao Chao-Qun , Wang Bi-Yu , Liu Hui , Guo Meng , Han Wei 
Published: July 2019

Abstract

Background:
Recent studies have demonstrated that coronary microcirculation dysfunction (CMVD) is closely correlated with adverse clinical outcomes. In this study, quantitative stress myocardial contrast echocardiography (MCE) was used to evaluate the CMVD and to investigate its association with the prognosis of patients with nonobstructive coronary artery disease (CAD).

Material and methods:
From 2006 to 2014, 227 consecutive patients with chest pain and a diagnostic coronary angiography without significant coronary artery stenosis (<50%) who underwent adenosine triphosphate disodium (ATP) stress MCE were enrolled. Quantitative MCE measurements were analyzed using replenishment curves.

Results:
Median follow-up time of this study was 5.3 years. Predictors of impaired coronary flow reserve (CFR) were smoking, diabetes, high apolipoprotein B, high low-density lipoprotein, serum uric acid, and low apolipoprotein A. During follow-up, 22 patients were reported to have 30 cardiac events (21 unstable angina, 3 nonfatal myocardial infarctions, 6 percutaneous coronary interventions). Using multivariate analysis, abnormal β reserve (≤1.6), impaired CFR (≤2.0), and diabetes were independent predictors of primary endpoint events in patients with nonobstructive CAD (P < .05). Multivariate analysis showed that CFR ≤2.0 (odds ratio [OR] =  25.21, 95% confidence interval [CI]: 3.01–182.32; P = .003), β reserve ≤1.6 (OR = 29.96, 95% CI: 3.5–241.27; P = .002), and diabetic (OR = 33.11, 95% CI: 3.65–300.02; P = .002) significantly increased the risk of the primary endpoint events.

Conclusions:
ATP stress quantitative MCE is a feasible and effective method to evaluate microcirculation abnormalities in human coronary arteries and it can be used for the clinical analysis, risk stratification, and treatment of early CAD.
Bone and joint infections with Staphylococcus aureus strains producing Panton–Valentine Leukocidin in French Guiana
Authors: Hardy Coralie , Osei Lindsay , Basset Thierry , Elenga Narcisse 
Published: July 2019

Abstract
The aim of this study was to describe the clinical features of bone and joint infections (BJI) due to Panton-Valentine Leukocidin producing (PVL+) Staphylococcus aureus (SA) in French Guiana.
A multicenter study that consists of a retrospective charts review of children admitted for PVL+ S. aureus BJI between January 2010 and December 2015.
Six patients with SA-PVL BJI were identified during the study period: 2 osteomyelitis, 1 septic arthritis, and 3 disseminated BJI. The median age was 11 years old (4–14 years), and fever lasted for 3.2 days (2–5 days) before diagnosis. An open skin wound preceded the BJI in 5/6 patients. One patient presented with a septic thrombophlebitis of the femoral-popliteal vein on admission. Methicillin-susceptible Staphylococcus aureus (MSSA) were identified for all patients. Three patients had complications: 2 cases of necrotizing pneumonia and 2 pericarditis, with 1 death caused by cardiac tamponade.

SA-PVL BJI was not frequent. Strains were susceptible to methicillin, but responsible of severe BJI. Early diagnosis and a multidisciplinary management of these infections are essential to prevent further complications.
The effect of anti-dementia drugs on Alzheimer disease-induced cognitive impairment
Authors: Cui Cui-Cui , Sun Yong , Wang Xin-Yi , Zhang Yuan , Xing Ying 
Published: July 2019

Abstract

Background:
Cognitive impairment is a principal manifestation of Alzheimer disease (AD). To provide a clinical reference for the treatment of AD, a network meta-analysis (NMA) was performed to evaluate the effects of different anti-dementia drugs on the cognitive impairment exhibited by patients with AD.

Methods:
Relevant randomized controlled trials are found through the Pubmed database, Web of Science, Clinical Trials, Embase, Cohranne library, Chinese National Knowledge Infrastructure database, CBM databases, and Wanfang among others. A total of 33 articles were collected, with the earliest document collected having been published in February 2017. The included reports were screened for quality of papers by using strict inclusion and exclusion criteria. All analyses were based on previously published studies reporting de-identified data; thus, no ethical approval or patient consent were required. The Mini-Mental State Examination scores informed the classification of the 33 articles into a mild subgroup, which featured 11 articles, and 12 drugs (besides a placebo); a moderate subgroup, which featured 17 articles and 15 drugs (besides a placebo); and a severe subgroup, which featured 5 articles and 3 drugs (besides a placebo).

Results:
While donepezil, galanthamine, and huperzine demonstrated the highest efficacy in the mild cognitive dysfunction subgroup (mean difference = 5.2, 2.5, and 2.4, respectively). Donepezil, huperzine A, and rivastigmine achieved the most significant effects in the moderate cognitive dysfunction subgroup (MD = 3.8, 2.9, and 3.0 respectively). In the severe subgroup, donepezil was demonstrably superior to memantine. Donepezil was thus found to effectively address cognitive impairment in patients with AD regardless of the degrees of cognitive decline.

Conclusions:
Evaluation of the clinically common anti-dementia drugs using NMA affirmed the utility of cholinesterase inhibitors, especially donepezil, in alleviating cognitive dysfunction of patients with AD. This study may therefore help to inform the clinical selection of pharmacotherapeutic interventions addressing cognitive dysfunction in patients with AD.