bluuebunny/crossref_metadata_2025_split huggingface dataset:
MCPIP1 alleviated lipopolysaccharide‐induced liver injury by regulating SIRT1 via modulation of microRNA‐9
Authors: Han Shichao , Li Zhenzhen , Ji Peng , Jia Yanhui , Bai Xiaozhi , Cai Weixia , Li Xiaoqiang , Yang Chen , Yang Yunshu , Yang Kuan , Wu Gaofeng , Zhang Wanfu , Hu Dahai 
Published: May 2019

AbstractThe severity of sepsis is associated with excessive inflammatory responses. MCP‐1 induced protein (MCPIP1) could negatively regulate inflammatory responses by deubiquitinating K48 or K63 polyubiquitins of TNF receptor‐associated factors. The function of MCPIP1 in negative regulation of inflammation is known, however, only the exact molecular pathway remains unknown. The aim of this study was to investigate whether and how MCPIP1 is involved in the regulation of lipopolysaccharides (LPS)‐induced liver injury. Macrophages and a mouse model were induced by LPS treatment. Several in vitro assays, such as quantitative real‐time PCR, immunoblotting, cell transfection, dual luciferase reporter assay, Enzyme‐linked immunosorbent assay, and Hematoxylin‐Eosin staining assay were used to explore the role of MCPIP1 and the interaction between MCPIP1, Sirtuin 1 (SIRT1), and microRNA‐9 (miR‐9). We found that the level of MCPIP1 increased and the level of SIRT1 decreased in LPS induced Kupffer cells or RAW 264.7 macrophages. Overexpression of MCPIP1 alleviated cytokine secretion and p65 nuclear translocation. Further study showed that MCPIP1 regulated p65 nuclear translocation by controlling p65 acetylation via promoting SIRT1 expression. Meanwhile, we found that miR‐9 could directly regulate SIRT1 transcription by binding to the 3′‐Untranslated Region of SIRT1 messenger RNA and that miR‐9 was negatively regulated by MCPIP1. Importantly, overexpression of MCPIP1 in vivo could alleviate LPS‐induced inflammation responses and liver injury in septic mice. These results demonstrated that MCPIP1 could alleviate inflammation responses and sepsis associated liver injury by promoting the expression of SIRT1, and miR‐9 was involved in the MCPIP1‐mediated regulation of SIRT1. Collectively, our results provide a possible novel signaling axis involving MCPIP1/miR‐9/SIRT1 in LPS‐induced septic mice.
Remote control of biofouling by heating PDMS/MnZn ferrite nanocomposites with an alternating magnetic field
Authors: Panigrahi Ritwik , Oh Hyun‐Suk , Sharma Vinay , Lee Kai Wei Kelvin , Rice Scott A , Cohn Daniel , Ramanujan Raju V 
Published: May 2019

AbstractBACKGROUNDThe accumulation of unwanted microorganisms on wetted surfaces, leading to surface damage and contamination, is a common and significant global issue.RESULTSHerein, we report a novel technique where the growth of microorganisms can be readily controlled by coating the surfaces with a polydimethylsiloxane (PDMS)/Mn0.8Zn0.2Fe2O4 (manganese‐zinc ferrite) nanocomposite followed by applying alternating magnetic field (AMF). The PDMS/MnZn ferrite nanocomposite is light weight and thermally stable (up to ∼ 330 °C) that can form a flexible coating. PDMS also provides hydrophobicity, which is further enhanced by the addition of Mn and Zn. The improved hydrophobicity makes the coated surface less susceptible to biofilm formation. When external AMF was applied to nanocomposites containing various MnZn ferrite nanoparticle loads of 10%, 20% and 30%, the temperature of the surface of nanocomposites reached to 80, 120 and 160 °C, respectively. Successful biofilm deactivation was achieved by heating the nanocomposites via AMF application, as shown in the biofilm test where up to ∼ 70% of the Pseudomonas aeruginosa PAO1 biofilm cells were killed when the AMF was applied for 20 min to the nanocomposites containing 30% nanoparticles.CONCLUSIONCoating the surface with PDMS/MnZn ferrite nanocomposites followed by applying external AMF can be an effective way to remove biofilm remotely in a wide range of applications. © 2019 Society of Chemical Industry
Prevalence and factors associated with fertility desires/intentions among individuals in HIV‐serodiscordant relationships: a systematic review of empirical studies
Authors: Martins Alexandra , Alves Stephanie , Chaves Catarina , Canavarro Maria C , Pereira Marco 
Published: May 2019

AbstractIntroductionBetter knowledge about fertility desires/intentions amongHIV‐serodiscordant partners who face unique challenges when considering childbearing may be helpful in the development of targeted reproductive interventions. The aim of this systematic review was to synthesize the published literature regarding the prevalence of fertility desires/intentions and its associated factors among individuals inHIV‐serodiscordant relationships while distinguishing low‐ and middle‐income countries (LMIC) from high‐income countries (HIC).MethodsA systematic search of all papers published prior to February 2017 was conducted in four electronic databases (PubMed/MEDLINE, PsycINFO, Web of Science and Cochrane Library). Empirical studies published in peer‐reviewed journals with individuals inHIV‐serodiscordant relationships assessing the prevalence of fertility desires/intentions and/or the associated factors were included in this systematic review. This review adhered to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines.Results and discussionAfter screening 1852 references, 29 studies were included, of which 21 were conducted inLMICand eight inHIC. A great variability in the prevalence of fertility desires/intentions was observed inLMIC(8% to 84% (one member of the dyad included)). InHIC, the results showed a smaller discrepancy between in the prevalence (32% to 58% (one member of the dyad included)); the prevalence was higher when the couple was the unit of analysis (64% to 73%), which may be related to the fact that all these studies were conducted in the context of assisted reproduction. Few studies examined the factors associated with fertility desires/intentions, and all except one were conducted inLMIC. Individuals (e.g. number of children), couple‐level (e.g. belief that the partner wanted children) and structural factors (e.g. discussions with health workers) were found to be associated.ConclusionsThe results of this systematic review suggest that many individuals inHIV‐serodiscordant relationships have fertility desires/intentions, although the prevalence is particularly heterogeneous inLMICin comparison toHIC. Well‐known factors such as younger age and a fewer number of living children were consistently associated with increased fertility desires/intentions. Different couple‐level factors emerged, reflecting the importance of considering both the individual and the couple. However, further studies that specifically focus on the dyad as the unit of analysis are warranted.
Dynamic effect of the South Asian high on the interannual zonal extension of the western North Pacific subtropical high
Authors: Wei Wei , Zhang Renhe , Wen Min , Yang Song , Li Wenhong 
Published: May 2019

AbstractThe South Asian high (SAH) and the North Pacific subtropical high (NPSH) are two crucial systems affecting the summer rainfall over East Asia. Features of the relative vorticity of the SAH and its dynamic effect on zonal extension of the western NPSH (WNPSH) are investigated on interannual timescales using data diagnosis and numerical model experiments. Results show that two climatological centres of negative relative vorticity are observed along the northern flank of the SAH over the Tibetan Plateau and northern West Asia at 200 hPa during boreal summer. The relatively more intense centre over the Tibetan Plateau (TPV) shows a pronounced southeast‐northwest (SE‐NW) variation, indicating a SE‐NW shift of the SAH. When the SAH shifts southeastward, an anomalous anticyclone occurs over eastern China at 200 hPa. In the middle troposphere, this anomalous anticyclone is located over southern China and the northern South China Sea, leading to a westward extension of the WNPSH. A diagnostic analysis of the vorticity equation indicates that the negative relative vorticity anomalies at 500 hPa are mainly caused by the downward advection of the mean relative vorticity by anomalous sinking motions. When the SAH extends southeastward, intense convergence on the southeastern flank of the anomalous upper‐level anticyclone induces descending motions that cause downward advection of mean negative vorticity. Consequently, negative vorticity anomaly is formed at 500 hPa, leading to a westward extension of the WNPSH. Results from the experiments using an idealized anomalous atmospheric general circulation model further demonstrate that the upper‐level anomalous anticyclone associated with a southeastward extension of the SAH triggers an anomalous anticyclone at the middle level, causing a westward extension of the WNPSH.
Date of harvesting affects yields and quality of Origanum vulgare ssp. hirtum (Link) Ietswaart
Authors: Król Beata , Kołodziej Barbara , Kędzia Bogdan , Hołderna‐Kędzia Elżbieta , Sugier Danuta , Luchowska Katarzyna 
Published: May 2019

AbstractBACKGROUNDThe aim of this experiment was to determine the essential oil, flavonoid and phenolic acid contents as well as yields of raw material collected from different morphological parts of Greek oregano in five consecutive developmental stages. Antibacterial and antifungal properties of methanol and hexane extracts from the aerial parts of Greek oregano were assessed as well.RESULTSThe findings showed that Greek oregano grown in the cool climate of central Europe had a considerable variation in the essential oil yield and chemical composition related to the harvesting stage. Forty volatile compounds were detected in essential oils, with the highest amount of carvacrol, thymol, p‐cymene and γ‐terpinene, constituting in total from 90.72 to 92.9%.CONCLUSIONDifferent morphological parts of the plants contained different amounts of essential oils, with dominant amounts in the flowers. The essential oil content systematically increased, reaching its maximum in the full blooming period. In that phase, the plants produced the highest yields of aboveground parts and provided approximately 190 L ha−1 of essential oils. Mainly owing to its content of phenolic compounds, the Greek oregano raw material exhibited relatively high antioxidant activity. The data obtained clearly showed the inhibitory activity of methanol and hexane extracts against pathogenic bacteria and fungi. © 2019 Society of Chemical Industry
Small pigmented eukaryotes play a major role in carbon cycling in the P‐depleted western subtropical North Atlantic, which may be supported by mixotrophy
Authors: Duhamel Solange , Kim Eunsoo , Sprung Ben , Anderson O. Roger 
Published: May 2019

AbstractWe found that in the phosphate (PO4)‐depleted western subtropical North Atlantic Ocean, small‐sized pigmented eukaryotes (P‐Euk; < 5 μm) play a central role in the carbon (C) cycling. Although P‐Euk were only ~ 5% of the microbial phytoplankton cell abundance, they represented at least two thirds of the microbial phytoplankton C biomass and fixed more CO2 than picocyanobacteria, accounting for roughly half of the volumetric CO2 fixation by the microbial phytoplankton, or a third of the total primary production. Cell‐specific PO4 assimilation rates of P‐Euk and nonpigmented eukaryotes (NP‐Euk; < 5 μm) were generally higher than of picocyanobacteria. However, when normalized to biovolumes, picocyanobacteria assimilated roughly four times more PO4 than small eukaryotes, indicating different strategies to cope with PO4 limitation. Our results underline an imbalance in the CO2 : PO4 uptake rate ratios, which may be explained by phagotrophic predation providing mixotrophic protists with their largest source of PO4. 18S rDNA amplicon sequence analyses suggested that P‐Euk was dominated by members of green algae and dinoflagellates, the latter group commonly mixotrophic, whereas marine alveolates were the dominant NP‐Euk. Bacterivory by P‐Euk (0.9 ± 0.3 bacteria P‐Euk−1 h−1) was comparable to values previously measured in the central North Atlantic, indicating that small mixotrophic eukaryotes likely exhibit similar predatory pressure on bacteria. Interestingly, bacterivory rates were reduced when PO4 was added during experimental incubations, indicating that feeding rate by P‐Euk is regulated by PO4 availability. This may be in response to the higher cost associated with assimilating PO4 by phagocytosis compared to osmotrophy.
Distributed Quantum Fiber Magnetometry
Authors: Maayani Shai , Foy Christopher , Englund Dirk , Fink Yoel 
Published: May 2019

AbstractNitrogen‐vacancy (NV) quantum magnetometers offer exceptional sensitivity and long‐term stability. However, their use to date in distributed sensing applications, including remote detection of ferrous metals, geophysics, and biosensing, is limited due to the need to combine optical, microwave (MW), and magnetic excitations into a single system. Existing approaches have yielded localized devices but not distributed capabilities. In this study, a continuous system‐in‐a‐fiber architecture is reported, which enables distributed magnetic sensing over extended lengths. Key to this realization is a thermally drawn fiber that has hundreds of embedded photodiodes connected in parallel and a hollow optical waveguide that contains a fluid with NV diamonds. This fiber is placed in a larger coaxial cable to deliver the required MW excitation. This distributed quantum sensor is realized in a water‐immersible 90‐m‐long cable with 102 detection sites. A sensitivity of 63 ± 5 nT Hz−1/2 per site, limited by laser shot noise, is established along a 90 m test section. This fiber architecture opens new possibilities as a robust and scalable platform for distributed quantum sensing technologies.
Effect of topography parameter, load, and surface roughness on friction coefficient in mixed lubrication regime
Authors: Prajapati Deepak K. , Tiwari Mayank 
Published: May 2019

AbstractSurface topography parameters significantly control physical processes which have asperity‐to‐asperity contacts in tribological components undergoing friction and wear. In this study, the effect of correlation length, maximum contact load, and surface roughness on friction coefficient and load distribution is studied. The load‐sharing concept is employed to determine friction coefficient and load distribution in the mixed‐lubrication regime. Results clearly demonstrate the effect of correlation length on friction coefficient and load distribution. It is found that the lower value of the coefficient of friction may be achieved even at low velocity for the smooth surface as compared with rough surfaces having higher surface roughness. For a particular value of velocity, the coefficient of friction decreases with an increase in maximum contact load. This work will help in predicting the coefficient of friction in the mixed‐lubrication regime for the engineering surfaces produced by processes like grinding, which is the result of an abrasive action.
Expanding the phenotypic spectrum of osteogenesis imperfecta type V including heterotopic ossification of muscle origins and attachments
Authors: Clewemar Pantelis , Hailer Nils P. , Hailer Yasmin , Klar Joakim , Kindmark Andreas , Ljunggren Östen , Stattin Eva‐Lena 
Published: May 2019

AbstractBackgroundOsteogenesis imperfecta (OI) is a clinical and genetic heterogeneous group of connective tissue disorders, characterized by bone fragility and a propensity to fracture.MethodsIn this report we describe the clinical phenotype of two patients, a 28‐year‐old woman and her mother (54 years old), both with a history of short stature and multiple fractures.ResultsExome sequencing revealed the recurring IFITM5:c.‐14 C>T variant causing OI type V. Both patients had several fractures during childhood. CT‐scan and scintigraphy showed ossification of the origin and attachment of muscles and hypertrophic callus formation.ConclusionOssification of the origin and attachment of muscles seems to be part of the phenotype in patients with OI type V.
Molecular aspects of collagenolysis associated with stress urinary incontinence in women with urethral hypermobility vs intrinsic sphincter deficiency
Authors: Candoso Bercina , Meneses Maria J. , Alves Marco G. , Sousa Mário , Oliveira Pedro F. 
Published: May 2019

AbstractAimsWe aimed to assess the alterations in specific molecular mechanisms associated with collagenolysis and their correlation in cases of stress urinary incontinence (SUI) by urethral hypermobility (UH) and by intrinsic sphincter deficiency (ISD).MethodsWe evaluated the messenger RNA (mRNA) expression of matrix metalloproteinases (MMP1, MMP2, and MMP9), specific tissue inhibitors of metalloproteinases (TIMPs), and associated proteins (TIMP1, TIMP2, and α‐2‐macroglobulin [A2McG]) in the suburethral tissue of women with SUI (half with SUI by UH and half with SUI by ISD) by reverse‐transcriptase quantitative polymerase chain reaction and determined the correlations of the expression of these proteins on each pathological condition.ResultsIn the suburethral tissue, we found significantly altered MMP2 mRNA levels, being higher in women with ISD than in those with UH. Still, MMP1 and MMP9 exhibited a tendency to a higher expression in women with ISD. Concerning the TIMPs expression, no significant statistical differences were found between women with UH and ISD. When evaluating the MMP/TIMP ratios, we found significant statistical differences between MMP9/TIMP1 and MMP9/A2McG. In fact, the correlations of the expression MMP9 with TIMP1 and A2McG were lost for women with UH. The ratios between MMP1/TIMP1 and MMP1/A2McG were similar, although there was a tendency of higher ratio in ISD for MMP2/TIMP2 and MMP2/A2McG.ConclusionOur results point toward higher collagenolysis in the suburethral tissue of women with SUI by ISD.
Numerical scheme for solving system of fractional partial differential equations with Volterra‐type integral term through two‐dimensional block‐pulse functions
Authors: Xie Jiaquan , Ren Zhongkai , Li Yugui , Wang Xiaogang , Wang Tao 
Published: May 2019

AbstractIn the current study, an approximate scheme is established for solving the fractional partial differential equations (FPDEs) with Volterra integral terms via two‐dimensional block‐pulse functions (2D‐BPFs). According to the definitions and properties of 2D‐BPFs, the original problem is transformed into a system of linear algebra equations. By dispersing the unknown variables for these algebraic equations, the numerical solutions can be obtained. Besides, the proof of the convergence of this system is given. Finally, several numerical experiments are presented to test the feasibility and effectiveness of the proposed method.
Sex and age‐biased exploitation and metric characterization of medium‐sized deer in the lower Paraná wetland, South America
Authors: Loponte Daniel , Corriale María José , Mucciolo Leonardo , Acosta Alejandro 
Published: May 2019

AbstractIn this paper, we present an analysis of the exploitation of medium‐sized deer in the lower Paraná wetland by pre‐Columbian hunter‐gatherers. To achieve this goal, we developed an osteometric frame of reference for the proper identification of hunted medium‐sized deer, and the sex and age of captured individuals. An analysis of 13 archaeofaunal assemblages showed that Ozotoceros bezoarticus (“pampas deer”) was the medium‐sized deer that was hunted with exclusivity. The presence of Mazama gouazoubira (“brown brocket deer”; “gray brocket deer”), which could have been another potentially hunted medium‐sized deer, is absent from the record, although this area is indicated as being its southernmost distribution range in South America. These results restrict the distribution of this species to a more northern sector of this large wetland. The hunted individuals of O. bezoarticus are all older than 2 years of age, and preferentially males, although some methodological bias could be influencing these results. Issues related to sex‐age selectivity in capturing these animals are discussed according to the development of conservation strategies for local resources.
The preburning condition of Chalcolithic cremated human remains from the Perdigões enclosures (Portugal)
Authors: Godinho Ricardo Miguel , Gonçalves David , Valera António Carlos 
Published: May 2019

AbstractThe Iberian Chalcolithic displayed a remarkable variety of funerary practices, which has been related to interpopulation differences, intrapopulation social‐cultural differences, and complex multistage funerary rituals. Perdigões, a Chalcolithic set of ditched enclosures, reflects such diversity including a wide array of funerary practices. Among those practices is cremation, which, despite relatively rare, is represented in different structures in Perdigões. One of these structures (Pit 40) presents an unparalleled high minimum number of individuals (n = 240), contrasting with nearby and coeval structures. In this study, we analyse heat‐induced bone changes and other archaeothanatological variables to tentatively assess the preburning condition of the human remains. The results of Pit 40 are also compared with other comparable contexts to assess if this unique context presents further funerary differences relative to those other contexts in, for example, body processing. Our results suggest preferential cremation of fleshed human remains, but burning of at least a minority of skeletonised remains and deposition of possibly unburned remains also likely occurred. Body processing appears to be comparable with that of the cremation contexts of Perdigões but contrasts with that of another nearby context (Dolmen of Olival da Pega 2b) in which burned bones were also found.
Preparation and characterization of novel PES‐(SiO2‐g‐PMAA) membranes with antifouling and hydrophilic properties for separation of oil‐in‐water emulsions
Authors: Khodadousti Saba , Zokaee Ashtiani Farzin , Karimi Mohammad , Fouladitajar Amir 
Published: May 2019

In the present study, modification of nanoparticles (NPs) was investigated to mitigate aggregation of SiO2 nanoparticles and improve the polymeric membrane's performance. For this purpose, the surface of SiO2 nanoparticles was activated with amine groups, and polymethacrylic acid (PMAA) was grafted on the surface of NPs by atom transfer radical polymerization. Modified NPs were characterized by Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) tests. Polyethersulfone (PES) membranes were fabricated with both SiO2 and SiO2‐g‐PMAA NPs via nonsolvent‐induced phase separation method. The fabricated membranes were characterized regarding their permeability, hydrophilicity, and porosity properties, and their separation efficiency was tested using the synthetic oil‐in‐water emulsion. The surface and cross‐sectional morphologies of membranes were observed by field emission scanning electron microscopy (FESEM). The experimental trials showed that modified NPs dispersed more uniformly in the structure of membranes and hydroxyl groups on the surface of NPs acted more effectively. Modification of NPs enhance the membrane performance in terms of permeate flux, hydrophilicity, and porosity. NPs modification improved the permeate flux about 46%. Oil rejection for all tested membranes was more than 98%, and modification of NPs did not reduce the rejection of membranes. The optimum concentration was obtained as 1 wt.% and 1.5 wt.% for SiO2 and SiO2‐g‐PMAA, respectively. Aggregation effect dominated at concentrations beyond the optimum values that decreased the permeate flux, consequently.