bluuebunny/crossref_metadata_2025_split huggingface dataset:
Couples’ psychological adjustment to twin parenthood: mode of conception (spontaneous versus assisted reproduction) and gender differences
Authors: Tendais Iva , Figueiredo Bárbara , Canário Catarina , Kenny David A. 
Published: April 2018

Abstract

Aim
To examine whether mode of conception and gender are associated with parents’ psychological adjustment across the transition to twin parenthood.

Background
There is limited knowledge on the psychological adjustment of couples to twin parenthood during pregnancy and early postpartum, especially for fathers. The available research suggests that first-time mothers of twins conceived by assisted reproduction techniques (ART) may experience lower psychosocial well-being than mothers of spontaneously conceived (SC) twins.

Methods
A total of 41 couples expecting twins, 25 of whom conceived spontaneously and 16 conceived by assisted reproduction techniques, completed measures of depressive and anxiety symptoms, marital relationship, attitudes to sex, and attitudes to pregnancy and the baby.

Findings
ART parents showed a decline in marital relationship quality, no changes in attitudes to pregnancy and the baby and no changes in attitudes to sex over the postpartum. In contrast, SC parents did not change their perception of the marital relationship, reported more positive attitudes to pregnancy and the baby, and more positive attitudes to sex over the postpartum. Compared with the other groups (SC mothers and fathers, ART fathers), ART mothers exhibited a higher increase in depressive and anxiety symptoms from pregnancy to postpartum and only anxiety symptoms exhibited a decline trend over the postpartum. These findings suggest that ART parents may experience more psychological difficulties during the transition to twin parenthood than SC parents. ART mothers, in particular, appear to be more at risk of high levels of postpartum depressive symptoms.
Akademische Selbstkonzepte und akademische Selbstwirksamkeiten: Interdependenzen und Beziehungen zu schulischen Leistungen
Authors: Feng Xiaoli , Wang Jin-Liang , Rost Detlef H. 
Published: April 2018

Zusammenfassung. Selbstkonzept und Selbstwirksamkeit sind zwei wichtige pädagogisch-psychologische Konstrukte. Über ihre gegenseitige Beziehung und diskriminanten und inkrementellen Vorhersagevaliditäten für schulische Leistungen ist nur wenig bekannt, weil sie zumeist separat analysiert wurden (entweder Selbstkonzept oder Selbstwirksamkeit). Untersucht wurden die Interdependenzen von drei schulfachspezifischen akademischen Selbstkonzeptskalen und drei schulfachspezifischen akademischen Selbstwirksamkeitsskalen sowie deren statistische Vorhersagekraft für Schulleistungen (Zensuren). Die Fächer waren Englisch, Geschichte und Mathematik. Untersucht wurden N = 825 Jugendliche, die chinesische Mittelschulen besuchten (Alter: M = 14.46 Jahre, SD = 0.79). Konfirmatorische Faktorenanalysen (CFA) belegten einerseits in jedem Schulfach zwei separate akademische „Selbst“-Faktoren (Selbstkonzept und Selbstwirksamkeit) und andererseits innerhalb eines jeden „Selbst“-Konstrukts drei Schulfachfaktoren (Englisch, Geschichte und Mathematik). Eine gemeinsame CFA über alle „Selbst“-Items führte zu sechs prägnanten Dimensionen: drei fachspezifische Selbstkonzeptfaktoren und drei fachspezifische Selbstwirksamkeitsfaktoren. Sparsamere Alternativmodelle waren weniger gut mit den Daten vereinbar. Entsprechend zusammengestellte Skalen hatten gute psychometrische Kennwerte. Multiple Regressionsanalysen und Kommunalitätenanalysen zeigten, dass die akademischen Selbstkonzeptskalen die erfassten Schulzensuren wesentlich besser statistisch vorhersagten als akademischen Selbstwirksamkeitsskalen. Die von beiden „Selbst“-Skalen gemeinsam aufgeklärten (d. h. nicht weiter aufteilbaren) Schulleistungsvarianzen betrugen 29.9 % (Englisch), 17.0 % (Geschichte) und 31.5 % (Mathematik). Die spezifischen (d. h. nicht mit der jeweiligen anderen „Selbst“-Skala konfundierten) Varianzaufklärungen lagen für die akademischen Selbstkonzepte bzw. akademischen Selbstwirksamkeiten bei 5.3 % bzw. 3.4 % (Englisch), bei 8.0 % bzw. 0.4 % (Geschichte) und bei 8.1 %. bzw. 1.8 % (Mathematik). Die Diskussion betont die große Relevanz der Schulfächer für die konzeptuelle und empirische Differenzierbarkeit sowie die Validität der beiden „Selbst“-Konstrukte.
Effect of Silicon, Carbon, and Sulfur on Structure of Liquid Iron and Implications for Structure‐Property Relations in Liquid Iron‐Light Element Alloys
Authors: Shibazaki Yuki , Kono Yoshio 
Published: April 2018

AbstractPlanetary cores are considered to be composed of iron (Fe) and light elements. Extensive studies on structure and properties of crystalline Fe‐light element alloys have been carried out to discuss composition and structure of the solid inner core. In contrast, structure and properties of liquid Fe‐light element alloys, which are important to discuss nature and dynamics of the liquid outer core, remain poorly understood. Here we conducted series of liquid structure measurements to systematically understand effect of silicon (Si), carbon (C), and sulfur (S) on structure of liquid Fe. We found that incorporation of Si in liquid Fe shortens the nearest (r1) and second (r2) neighbor distances, while incorporation of C and small amount of S expands these distances. The different structural behavior is interpreted in view of different light‐element incorporation mechanisms: substitutional incorporation of Si and interstitial incorporation of C and S. All light elements lower density of liquid Fe regardless of shortening or expansion of the r1 and r2 distances, while P‐wave velocities of liquid Fe‐light element alloys show linear increase with shortening of the r1 and r2. The different light‐element incorporation behavior in the structure of liquid Fe and the resultant variation in the properties of liquid Fe‐light element alloys should be important in understanding behavior of liquid Fe‐light element alloys in the planetary cores.
Transparent and attachable ionic communicators based on self-cleanable triboelectric nanogenerators
Authors: Lee Younghoon , Cha Seung Hee , Kim Yong-Woo , Choi Dukhyun , Sun Jeong-Yun 
Published: April 2018

AbstractHuman–machine interfaces have benefited from the advent of wireless sensor networks and the internet of things, but rely on wearable/attachable electronics exhibiting stretchability, biocompatibility, and transmittance. Limited by weight and volume, wearable devices should be energy efficient and even self-powered. Here, we report practical approaches for obtaining a stably self-cleanable, transparent and attachable ionic communicator based on triboelectric nanogenerators. The communicator can be easily applied on human skin due to softness and chemically anchored robust layers. It functions as a means of real-time communication between humans and machines. Surface functionalization on the communicator by (heptadecafluoro-1,1,2,2-tetrahydrodecyl)trichlorosilane improves sensitivity and makes the communicator electrically and optically stable due to the self-cleaning effect without sacrificing transmittance. This research may benefit the potential development of attachable ionics, self-powered sensor networks, and monitoring systems for biomechanical motion.
Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB
Authors: Bräuning Bastian , Bertosin Eva , Praetorius Florian , Ihling Christian , Schatt Alexandra , Adler Agnes , Richter Klaus , Sinz Andrea , Dietz Hendrik , Groll Michael 
Published: April 2018

AbstractPore-forming toxins (PFT) are virulence factors that transform from soluble to membrane-bound states. The Yersinia YaxAB system represents a family of binary α-PFTs with orthologues in human, insect, and plant pathogens, with unknown structures. YaxAB was shown to be cytotoxic and likely involved in pathogenesis, though the molecular basis for its two-component lytic mechanism remains elusive. Here, we present crystal structures of YaxA and YaxB, together with a cryo-electron microscopy map of the YaxAB complex. Our structures reveal a pore predominantly composed of decamers of YaxA–YaxB heterodimers. Both subunits bear membrane-active moieties, but only YaxA is capable of binding to membranes by itself. YaxB can subsequently be recruited to membrane-associated YaxA and induced to present its lytic transmembrane helices. Pore formation can progress by further oligomerization of YaxA–YaxB dimers. Our results allow for a comparison between pore assemblies belonging to the wider ClyA-like family of α-PFTs, highlighting diverse pore architectures.
Ediacara biota flourished in oligotrophic and bacterially dominated marine environments across Baltica
Authors: Pehr Kelden , Love Gordon D. , Kuznetsov Anton , Podkovyrov Victor , Junium Christopher K. , Shumlyanskyy Leonid , Sokur Tetyana , Bekker Andrey 
Published: April 2018

AbstractMiddle-to-late Ediacaran (575–541 Ma) marine sedimentary rocks record the first appearance of macroscopic, multicellular body fossils, yet little is known about the environments and food sources that sustained this enigmatic fauna. Here, we perform a lipid biomarker and stable isotope (δ15Ntotal and δ13CTOC) investigation of exceptionally immature late Ediacaran strata (<560 Ma) from multiple locations across Baltica. Our results show that the biomarker assemblages encompass an exceptionally wide range of hopane/sterane ratios (1.6–119), which is a broad measure of bacterial/eukaryotic source organism inputs. These include some unusually high hopane/sterane ratios (22–119), particularly during the peak in diversity and abundance of the Ediacara biota. A high contribution of bacteria to the overall low productivity may have bolstered a microbial loop, locally sustaining dissolved organic matter as an important organic nutrient. These oligotrophic, shallow-marine conditions extended over hundreds of kilometers across Baltica and persisted for more than 10 million years.
Unconventional slowing down of electronic recovery in photoexcited charge-ordered La1/3Sr2/3FeO3
Authors: Zhu Yi , Hoffman Jason , Rowland Clare E. , Park Hyowon , Walko Donald A. , Freeland John W. , Ryan Philip J. , Schaller Richard D. , Bhattacharya Anand , Wen Haidan 
Published: April 2018

AbstractThe coupling of ordered electronic phases with lattice, spin, and orbital degrees of freedom are of central interest in strongly correlated systems. Their interplay has been intensively studied from femtosecond to picosecond time scales, while their dynamics beyond nanoseconds are usually assumed to follow lattice cooling. Here, we report an unusual slowing down of the recovery of an electronic phase across a first-order phase transition. Following optical excitation, the recovery time of both transient optical reflectivity and X-ray diffraction intensity from the charge-ordered superstructure in a La1/3Sr2/3FeO3 thin film increases by orders of magnitude as the sample temperature approaches the phase transition temperature. In this regime, the recovery time becomes much longer than the lattice cooling time. The combined experimental and theoretical investigation shows that the slowing down of electronic recovery corresponds to the pseudo-critical dynamics that originates from magnetic interactions close to a weakly first-order phase transition.
Optical circulation in a multimode optomechanical resonator
Authors: Ruesink Freek , Mathew John P. , Miri Mohammad-Ali , Alù Andrea , Verhagen Ewold 
Published: April 2018

AbstractBreaking the symmetry of electromagnetic wave propagation enables important technological functionality. In particular, circulators are nonreciprocal components that can route photons directionally in classical or quantum photonic circuits and offer prospects for fundamental research on electromagnetic transport. Developing highly efficient circulators thus presents an important challenge, especially to realise compact reconfigurable implementations that do not rely on magnetic fields to break reciprocity. We demonstrate optical circulation utilising radiation pressure interactions in an on-chip multimode optomechanical system. Mechanically mediated optical mode conversion in a silica microtoroid provides a synthetic gauge bias for light, enabling four-port circulation that exploits tailored interference between appropriate light paths. We identify two sideband conditions under which ideal circulation is approached. This allows to experimentally demonstrate ~10 dB isolation and <3 dB insertion loss in all relevant channels. We show the possibility of actively controlling the circulator properties, enabling ideal opportunities for reconfigurable integrated nanophotonic circuits.
Ambient ammonia synthesis via palladium-catalyzed electrohydrogenation of dinitrogen at low overpotential
Authors: Wang Jun , Yu Liang , Hu Lin , Chen Gang , Xin Hongliang , Feng Xiaofeng 
Published: April 2018

AbstractElectrochemical reduction of N2 to NH3 provides an alternative to the Haber−Bosch process for sustainable, distributed production of NH3 when powered by renewable electricity. However, the development of such process has been impeded by the lack of efficient electrocatalysts for N2 reduction. Here we report efficient electroreduction of N2 to NH3 on palladium nanoparticles in phosphate buffer solution under ambient conditions, which exhibits high activity and selectivity with an NH3 yield rate of ~4.5 μg mg−1Pd h−1 and a Faradaic efficiency of 8.2% at 0.1 V vs. the reversible hydrogen electrode (corresponding to a low overpotential of 56 mV), outperforming other catalysts including gold and platinum. Density functional theory calculations suggest that the unique activity of palladium originates from its balanced hydrogen evolution activity and the Grotthuss-like hydride transfer mechanism on α-palladium hydride that lowers the free energy barrier of N2 hydrogenation to *N2H, the rate-limiting step for NH3 electrosynthesis.
Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology
Authors: Nagata Kenichi , Takahashi Mika , Matsuba Yukio , Okuyama-Uchimura Fumi , Sato Kaori , Hashimoto Shoko , Saito Takashi , Saido Takaomi C. 
Published: April 2018

AbstractAlthough, a number of pathogenic mutations have been found for Alzheimer’s disease (AD), only one protective mutation has been identified so far in humans. Here we identify possible protective deletion mutations in the 3′-UTR of the amyloid precursor protein (App) gene in mice. We use an App knock-in mouse model carrying a humanized Aβ sequence and three AD mutations in the endogenous App gene. Genome editing of the model zygotes using multiple combinations of CRISPR/Cas9 tools produces genetically mosaic animals with various App 3′-UTR deletions. Depending on the editing efficiency, the 3′-UTR disruption mitigates the Aβ pathology development through transcriptional and translational regulation of APP expression. Notably, an App knock-in mouse with a 34-bp deletion in a 52-bp regulatory element adjacent to the stop codon shows a substantial reduction in Aβ pathology. Further functional characterization of the identified element should provide deeper understanding of the pathogenic mechanisms of AD.
Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1
Authors: Ederle Helena , Funk Christina , Abou-Ajram Claudia , Hutten Saskia , Funk Eva B. E. , Kehlenbach Ralph H. , Bailer Susanne M. , Dormann Dorothee 
Published: April 2018

AbstractTDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of neurons and glial cells. Defects in nucleocytoplasmic transport contribute to this pathology, hence nuclear import of both proteins has been studied in detail. However, their nuclear export routes remain poorly characterized and it is unclear whether aberrant nuclear export contributes to TDP-43 or FUS pathology. Here we show that predicted nuclear export signals in TDP-43 and FUS are non-functional and that both proteins are exported independently of the export receptor CRM1/Exportin-1. Silencing of Exportin-5 or the mRNA export factor Aly/REF, as well as mutations that abrogate RNA-binding do not impair export of TDP-43 and FUS. However, artificially enlarging TDP-43 or FUS impairs their nuclear egress, suggesting that they could leave the nucleus by passive diffusion. Finally, we found that inhibition of transcription causes accelerated nuclear egress of TDP-43, suggesting that newly synthesized RNA retains TDP-43 in the nucleus, limiting its egress into the cytoplasm. Our findings implicate reduced nuclear retention as a possible factor contributing to mislocalization of TDP-43 in ALS/FTD.
Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization
Authors: Pinarbasi Emile S. , Cağatay Tolga , Fung Ho Yee Joyce , Li Ying C. , Chook Yuh Min , Thomas Philip J. 
Published: April 2018

AbstractALS (Amyotrophic Lateral Sclerosis) is a neurodegenerative disease characterized by the redistribution of the RNA binding protein TDP-43 in affected neurons: from predominantly nuclear to aggregated in the cytosol. However, the determinants of TDP-43 localization and the cellular insults that promote redistribution are incompletely understood. Here, we show that the putative Nuclear Export Signal (NES) is not required for nuclear egress of TDP-43. Moreover, when the TDP-43 domain which contains the putative NES is fused to a reporter protein, YFP, the presence of the NES is not sufficient to mediate nuclear exclusion of the fusion protein. We find that the previously studied “∆NES” mutant, in which conserved hydrophobic residues are mutated to alanines, disrupts both solubility and splicing function. We further show that nuclear export of TDP-43 is independent of the exportin XPO1. Finally, we provide evidence that nuclear egress of TDP-43 is size dependent; nuclear export of dTomato TDP-43 is significantly impaired compared to Flag TDP-43. Together, these results suggest nuclear export of TDP-43 is predominantly driven by passive diffusion.
Major ocular trauma in Taiwan: 2002–2004 versus 2012–2014
Authors: Chang Yi-Sheng , Teng Yu-Ti , Huang Yi-Hsun , Liu Mei-Ling , Hung Jia-Horung , Hsu Sheng-Min , Huang Fu-Chin , Shih Min-Hsiu , Chen Wan-Ju , Lai Chun-Chieh , Hsiao Shu-Fang , Wang Shih-Hao , Tseng Sung-Huei 
Published: April 2018

AbstractWe investigated the temporal changes in major eye injuries in Taiwan by reviewing the medical records of all patients with ocular trauma hospitalized at the National Cheng Kung University Hospital during 2002–2004 and 2012–2014. A total of 169 eyes (161 patients) during 2002–2004 and 121 eyes (120 patients) during 2012–2014 were enrolled (mean ± SD age: 41.9 ± 20.8 years in 2002–2004, and 51.8 ± 19.3 years in 2012–2014). Males accounted for ~75% of patients. The most frequent injury-causing object was metallic material (~24%), and blunt traumas were most frequently attributable to traffic accidents and falls. The most common locations of injuries for males and females were the workplace and home, respectively. Open-globe injuries occurred in ~70% of eyes, requiring primary repair, cataract extraction, and/or intraocular lens implantation. The frequencies of fall injury, lacrimal system laceration, lens injury, corneal/scleral foreign bodies, and use of intracameral antibiotics increased from 2002–2004 to 2012–2014, while those of closed-globe injury, vitreous haemorrhage, optic nerve injury, and medical treatment decreased. The final visual acuity remained poor (≤20/200) in >1/3 of injured eyes. Despite therapeutic advancements, major eye injuries still pose a high risk for poor visual outcome.
Perception of partial slips under tangential loading of the fingertip
Authors: Barrea Allan , Delhaye Benoit P. , Lefèvre Philippe , Thonnard Jean-Louis 
Published: April 2018

AbstractDuring tactile exploration, partial slips occur systematically at the periphery of fingertip-object contact prior to full slip. Although the mechanics of partial slips are well characterized, the perception of such events is unclear. Here, we performed psychophysical experiments to assess partial slip detection ability on smooth transparent surfaces. In these experiments, the index fingertip of human subjects was stroked passively by a smooth, transparent glass plate while we imaged the contact slipping against the glass. We found that subjects were able to detect fingertip slip before full slip occurred when, on average, only 48% of the contact area was slipping. Additionally, we showed that partial slips and plate displacement permitted slip detection, but that the subjects could not rely on tangential force to detect slipping of the plate. Finally, we observed that, keeping the normal contact force constant, slip detection was impeded when the plate was covered with a hydrophobic coating dramatically lowering the contact friction and therefore the amount of fingertip deformation. Together, these results demonstrate that partial slips play an important role in fingertip slip detection and support the hypothesis that the central nervous system relies on them to adjust grip force during object manipulation.
Identification of miRNAs in cervical mucus as a novel diagnostic marker for cervical neoplasia
Authors: Kawai Satoshi , Fujii Takuma , Kukimoto Iwao , Yamada Hiroya , Yamamoto Naoki , Kuroda Makoto , Otani Sayaka , Ichikawa Ryoko , Nishio Eiji , Torii Yutaka , Iwata Aya 
Published: April 2018

AbstractmicroRNAs (miRNAs) play important roles in regulation of gene expression during cervical carcinogenesis. We investigated expression profiles of miRNAs in cervical cancer and its precursor lesions by utilizing cervical mucus. Cervical mucus was collected from 230 patients with a normal cervix, cervical intraepithelial neoplasia (CIN), squamous cell carcinoma (SCC), or adenocarcinoma (AD). The levels of miRNA in the mucus were quantified by miRNA array and real-time reverse-transcriptase polymerase chain reaction (RT-PCR). The performance for detecting diseases was statistically analysed. The expression of miRNAs was further validated in the surgical tissues of enrolled patients. Four miRNAs (miR-126-3p, -20b-5p, -451a, and -144-3p) were significantly up-regulated in SCC and AD compared with normal, and their expression levels correlated with disease severity and high-risk human papillomavirus infection. Receiver operating characteristic curve analyses revealed that the area under the curve values for miR-126-3p, -20b-5p, -451a, and -144-3p were 0.89, 0.90, 0.94, and 0.93, respectively, for SCC plus AD compared with normal, showing high accuracy of cancer detection. Real-time RT-PCR analyses confirmed the expression of these four miRNAs in frozen tissues from cervical cancer. miR-126-3p, -20b-5p, -451a, and -144-3p in cervical mucus are promising biomarkers for cervical cancer and high-grade CINs.