bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of nasal endoscopic dacryocystorhinostomy for chronic dacryocystitis
Authors: Chen Xiao , Liu Yang 
Published: March 2019

Abstract

Background:
This study aims to assess the efficacy and safety of nasal endoscopic dacryocystorhinostomy (NED) for patients with chronic dacryocystitis (CD).

Methods:
The following 7 electronic databases will be searched from inception to the present: Cochrane Library, EMBASE, MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database. In addition, the clinical trials registry and reference lists of included studies will also be searched. We will only include randomized controlled trials of NED for CD in this systematic review. Two review authors independently carry out the study selection, data extraction, and methodological quality assessment. Whenever it is possible, we will pool the data and conduct meta-analysis by using RevMan 5.3 software.

Results:
This study will evaluate the efficacy and safety of NED for patients with CD. The primary outcome includes success rate of ostial patency. The secondary outcomes consist of duration of surgery, quality of life, postoperative complications, and surgeon's comfort.

Conclusion:
The findings of this study may summarize the latest evidence of NED for patients with CD.

PROSPERO registration number:
PROSPERO CRD42019123664.
Can we predict vascular status and culture result based through wound status in diabetic foot infection?
Authors: Shin Jin Yong , Roh Si-Gyun , Chang Suk Choo , Lee Nae-Ho 
Published: March 2019

Abstract
Diabetic foot infection (DFI) should be treated by a multidisciplinary team to prevent amputation and morbid status. As physicians encountering DFI in outpatient clinic, a proper selection of antibiotic treatment and diagnostic approach for a vascular status is essential. We retrospectively investigated the patients with DFI from 2016 to 2017. All patients were examined for vascular status, wound status, and pathologic culture preceding the treatment. No statistical significance was observed between PEDIS grade 1 and 2 and 3 and 4 in culture status and culture results. Association analysis between vascular status and other variables, such as wound score and culture results, has no significant difference. Through these results, the helpful epidemiologic result of microbiology and necessity of examination for peripheral arterial disease were verified.
Establish new formulas for the calculation of renal and isthmus depth in horseshoe kidney
Authors: Ma Guangyu , Chen Yingmao , Shao Mingzhe , Tian Jiahe , Xu Baixuan 
Published: March 2019

Abstract
This study was performed to develop a new formula to estimate the renal and isthmus depth in horseshoe kidney, and to compare the new formula with previously published formulas.
Renal depth, isthmus depth, vertebral thickness, and total thickness (T, cm) of the body at the level of the kidneys were measured by CT in 124 adults. Their sex, age, height (H, cm), and weight (W, kg) were recorded. Multiple stepwise linear regression analysis was conducted. The 124 cases were divided into 2 random groups, of which the first group was used to derive a regressive formula and the second group was used to verify the formula and compare the formula with previously published formulas.
Multiple stepwise linear regression analysis showed that the important variables in estimating the depth of each kidney were the body weight (W, kg) and the total thickness (T, cm) of the body at the level of the kidneys. The important variables in estimating the depth of isthmus soft tissue and vertebral thickness were W, T, and age, W. The new formula was the following: right renal depth (cm) = 0.273 × T + 0.043 × W + 1.086 (r = 0.82, P < .05; standardized regressive coefficient: T = 0.500, W = 0.367), left renal depth (cm) = 0.245 × T + 0.041 × W + 0.676 (r = 0.83, P < .05; standardized regressive coefficient: T = 0.520, W = 0.353); isthmus depth (cm) = soft tissue depth + vertebral thickness, soft tissue depth (cm) = 0.144 × T + 0.044 × W + 0.536 (r = 0.58, P < .05; standardized regressive coefficient: T = 0.272, W = 0.335), vertebral thickness (cm) = 0.012 × age + 0.018 × W + 3.683 (r = 0.53, P < .05; standardized regressive coefficient: age = 0.326, W = 0.438). It is much better than the literatures.
The new renal depth estimation formula in horseshoe kidney that we derived by using multiple stepwise linear regression has greatly outperformed other 6 previously published formulas. Isthmus depth estimation formula can also get accurate results. Our new formula provides a more reliable and accurate renal and isthmus depth estimation and contributes to improving the methods used to estimate renal function from radionuclide renography in horseshoe kidney.
Serum YKL-40 predicts long-term outcome in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction
Authors: Yang Luyu , Dong Hui , Lu Huizhi , Liao Youxia , Zhang Hao , Xu Lingwen , Tan Yun , Cao Song , Tan Jinhui , Fu Shouzhi 
Published: March 2019

Abstract
Serum YKL-40, a potential inflammatory marker, is greatly increased at the early stage of ST-segment elevation myocardial infarction (STEMI). Here, we hypothesized that YKL-40 levels at admission could predict the long-term outcomes after STEMI.
A total of 324 patients with acute STEMI undergoing primary percutaneous coronary intervention (PCI) were consecutively enrolled and followed for 24 months. The baseline clinical and procedural data were recorded, and serum YKL-40 levels at admission were measured using ELISA method. The endpoint of interest was major adverse cardiac event (MACE), including all-cause death, recurrent myocardial infarction, and hospitalization for heart failure.
Patients with elevated serum YKL-40 levels (≥126.8 ng/mL) were more likely to be older and smoker and to present with type 2 diabetes, advanced Killip class, multivessel disease and intra-aortic balloon pump, with increased levels of admission glucose, triglyceride, and high-sensitivity C-reactive protein and decreased level of high-density lipoprotein cholesterol. During the follow-up period, the incidence of MACE was notably higher in the high than in the low YKL-40 groups (28.4% vs 11.1%, P < .001). Kaplan–Meier curve showed that elevated YKL-40 levels were associated with reduced MACE-free survivals (log-rank P < .001). In multivariate Cox regression analysis, we found that high serum YKL-40 level was an independent predictor of MACE after controlling for clinical and angiographic variables (hazard ratio: 1.65, 95% confidence interval: 1.14–2.39, P = .008).
The results of our study indicate that serum YKL-40 may be used as a biomarker to predict the long-term outcome after PCI in patients with STEMI.
The diagnostic value of circulating tumor cells for lung cancer
Authors: Ye Yun , Li Su-Liang , Wang Jian-Jun , Liu Bing 
Published: March 2019

Abstract

Background:
Circulating tumor cells (CTCs) have become a potential diagnostic tumor marker and have the potential for wide clinical applications. However, the diagnostic parameters vary among previous studies. A systematic review of the literature and meta-analysis were conducted to assess the diagnostic value of CTCs for lung cancer.

Methods:
Eligible studies were searched in PubMed, Medline, Cochrane Library, and Embase databases. The included studies assessed the diagnostic value of CTCs in patients with lung cancer up to September 30, 2018. A total of 1601 patients in 8 studies were included in the meta-analysis. We calculated the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) to investigate the diagnostic value of CTCs for lung cancer. STATA version 12.0 and Meta-DiSc version 1.4 software were used to analyze the data.

Results:
The pooled sensitivity was 0.75 (95% CI: 0.73–0.78), the specificity was 0.89 (95% CI: 0.86–0.92), the PLR was 6.29 (95% CI: 3.98–9.96), and the NLR was 0.24 (95% CI: 0.14–0.42). Furthermore, the pooled DOR of CTCs for lung cancer was 27.73 (95% CI: 12.99–59.23). The summarized area under the ROC curve was 0.93 (95% CI: 0.90–0.95). The meta-regression analysis suggested that the heterogeneity was mainly attributed to the experimental methods. The results of the clinical diagnosis efficiency show that the diagnostic efficiency has increased significantly by testing CTCs for diagnosing lung cancer.

Conclusion:
The results of this meta-analysis suggest that CTCs are associated with a high diagnostic value for lung cancer. These findings require large-scale prospective studies to verify and evaluate the diagnostic value in the future.
Association of TFPI polymorphisms rs8176592, rs10931292, and rs10153820 with venous thrombosis
Authors: Zhang Yunhong , Pang Aimei , Zhao Lin , Guo Qiang , Zhang Zhen , Zhu Xiaoxiao , Wei Ran , Yin Xunqiang , Wang Bin , Li Xia 
Published: March 2019

Abstract

Background:

Tissue factor pathway inhibitor (TFPI) polymorphisms are known to be involved in venous thrombosis; however, any correlation between the TFPI polymorphisms rs8176592, rs10931292, and rs10153820 and venous thrombosis remains controversial. This meta-analysis aimed to elucidate the relationship between these TFPI polymorphisms and the susceptibility to venous thrombosis.

Methods:
A literature search for relevant studies was conducted in PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang Med Online databases. Odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were calculated using fixed-effect/random-effect models by the STATA 12.0 software. Sources of heterogeneity were analyzed by subgroup analysis.

Results:
Eleven case-control studies involving 3740 subjects (1362 venous thrombosis patients and 2378 healthy controls) were included. The TFPI rs8176592 polymorphism was associated with increased risk of venous thrombosis in the whole population, while no significant association was found between rs10931292/rs10153820 and venous thrombosis. In subgroup analysis based on ethnicity, an increased risk was observed with rs8176592 polymorphism in Asians (Recessive model, OR = 1.48, 95% CI = 1.06–2.07, P = .023). An increased risk associated with rs10931292 was identified in non-Asians (Recessive model, OR = 1.42, 95% CI = 1.03–1.97, P = .033). No significant association was found in either Asians or non-Asians with the rs10153820 polymorphism. In subgroup analysis based on source of controls, increased risks were identified in the hospital-based group with rs8176592 polymorphism and in the population-based group with rs10931292 polymorphism, whereas decreased risk was identified in the hospital-based group with the rs10931292 and rs10153820 polymorphisms.

Conclusion:
Meta-analysis suggested that different TFPI polymorphisms may have different associations with venous thrombosis. TFPI rs8176592 polymorphism may increase the risk of venous thrombosis, especially in Asians and hospital-based patients. The TFPI rs10931292 polymorphism may increase the venous thrombosis risk for both non-Asians and population-based patients. Moreover, rs10931292 and rs10153820 polymorphisms of TFPI may decrease the risk of venous thrombosis for hospital-based patients.
Precision medicine in pediatric sepsis
Authors: Atreya Mihir R. , Wong Hector R. 
Published: March 2019

Purpose of review
Pediatric sepsis is a heterogeneous state associated with significant morbidity and mortality, but treatment strategies are limited. Clinical trials of immunomodulators in sepsis have shown no benefit, despite having a strong biological rationale. There is considerable interest in application of a precision medicine approach to pediatric sepsis to identify patients who are more likely to benefit from targeted therapeutic interventions.

Recent findings
Precision medicine requires a clear understanding of the molecular basis of disease. ‘Omics data’ and bioinformatics tools have enabled identification of endotypes of pediatric septic shock, with corresponding biological pathways. Further, using a multibiomarker-based approach, patients at highest risk of poor outcomes can be identified at disease onset. Enrichment strategies, both predictive and prognostic, may be used to optimize patient selection in clinical trials and identify a subpopulation in whom therapy of interest may be trialed. A bedside-to-bench-to-bedside model may offer clinicians pragmatic tools to aid in decision-making.

Summary
Precision medicine approaches may be used to subclassify, risk-stratify, and select pediatric patients with sepsis who may benefit from new therapies. Application of precision medicine will require robust basic and translational research, rigorous clinical trials, and infrastructure to collect and analyze big data.
Influence of Gender, Profession, and Managerial Function on Clinicians’ Perceptions of Patient Safety Culture: A Cross-National Cross-Sectional Study
Authors: Gambashidze Nikoloz , Hammer Antje , Wagner Anke , Rieger Monika A. , Brösterhaus Mareen , Van Vegten Amanda , Manser Tanja ,   on behalf of the WorkSafeMed Consortium
Published: March 2019

Objectives
In recent years, several instruments for measuring patient safety culture (PSC) have been developed and implemented. Correct interpretation of survey findings is crucial for understanding PSC locally, for comparisons across settings or time, as well as for planning effective interventions. We aimed to evaluate the influence of gender, profession, and managerial function on perceptions of PSC and on the interplay between various dimensions and perceptions of PSC.

Methods
We used German and Swiss survey data of frontline physicians and nurses (n = 1786). Data analysis was performed for the two samples separately using multivariate analysis of variance, comparisons of adjusted means, and series of multiple regressions.

Results
Participants’ profession and managerial function had significant direct effect on perceptions of PSC. Although there was no significant direct effect of gender for most of the PSC dimensions, it had an indirect effect on PSC dimensions through statistically significant direct effects on profession and managerial function. We identified similarities and differences across participant groups concerning the impact of various PSC dimensions on Overall Perception of Patient Safety. Staffing and Organizational Learning had positive influence in most groups without managerial function, whereas Teamwork Within Unit, Feedback & Communication About Error, and Communication Openness had no significant effect. For female participants without managerial functions, Management Support for Patient Safety had a significant positive effect.

Conclusions
Participant characteristics have significant effects on perceptions of PSC and thus should be accounted for in reporting, interpreting, and comparing results from different samples.
The Relationship Between Culture of Safety and Rate of Adverse Events in Long-Term Care Facilities
Authors: Abusalem Said , Polivka Barbara , Coty Mary-Beth , Crawford Timothy N. , Furman Christian D. , Alaradi Maryam 
Published: March 2019

Objective
The aim of the study was to assess the relationship of culture of safety dimensions and the rate of unanticipated care outcomes in long-term care facilities (LTCFs) using the Agency for Healthcare Research and Quality framework of resident safety culture.

Methods
Cross-sectional survey data were collected on 13 dimensions of culture of safety in five LTCFs from registered nurses, licensed practical nurses (LPNs), nursing assistants, administrators/managers, administrative support, and rehabilitation staff. Secondary data on falls in the five LTCFs from quarters 1 to 3 of 2014 were obtained from the Centers for Medicare and Medicaid Services in February 2015. Spearman’s ρ and the Generalized Estimating Equations using a log link (Poisson distribution) were used.

Results
Communication and feedback about incidences reported the highest mean scores (M = 4.35, SD =0.71). Higher rate of falls was associated with a lower level of team work, lower degree of handoffs, and lower levels of organizational learning. The risk for falls increased as the number of residents per facility increased (rate ratio [RR] = 1.02; 95% confidence interval [CI] = 1.01–1.02) and as the number of LPN hours per resident increased (RR = 37.7, 95% CI = 18.5–76.50). Risk for long stay urinary tract infections increased as number of residents increased (RR =1.01, 95% CI =1.01–1.01). Increase in culture of safety score was associated with decrease in risk of falls, long stay urinary tract infections, and short stay ulcers.

Conclusions
With the shortage of registered nurses in LTCFs and new reimbursement regulations, many LTCFs are hiring LPNs to have full staffing and save money. Licensed practical nurses may lack essential knowledge to decrease the rate of falls.
Postural Changes After Abdominoplasty in Morbid Obese Patients
Authors: Grella Roberto , Del Torto Giuseppe , Nicoletti Giovanni Francesco , D'Andrea Francesco 
Published: March 2019

Background
In the multidisciplinary treatment of obesity, the role of a plastic surgeon is to remove the excess of skin after weight loss to obtain cosmetic, functional, and psychological benefits. Obesity modifies body geometry, increases the mass of different segments, and imposes functional limitations in life activities that may predispose the obese to injury. The authors evaluated the postural conditions of obese patients, before and 12 months after surgery.

Methods
The study included 15 obese patients of both genders affected by class II obesity. Postural function was evaluated preoperatively and 12 months postoperatively. Patients underwent conventional abdominoplasty surgical procedure. In all patients, plantar pressure distribution and balance (stabilometric test) were evaluated before and 3 months after surgery.

Results
The static pedobarographic revealed a significant reduction in forefoot peak pressure; total plantar force; rearfoot plantar force percentage; midfoot plantar force percentage; and forefoot, midfoot, and rearfoot plantar contact areas percentage 3 months after surgery; the dynamic's one showed a reduction in the first metatarsal peak pressure and plantar contact. The stabilometric values showed a reduction in the range of center of foot pressure (CP) displacement along y axis, the average displacement of the CP speed from the mean (RMS y velocity), and CP mean peak in the condition of vision.

Conclusions
Our study demonstrates the beneficial effect of dermolipectomies and the consequential weight loss on postural stability of obese men. Such findings may support the hypothesis that dermolipectomy may improve postural stability with and without vision. The data demonstrate that the benefits are related to the magnitude of the resected tissue.
Dorsal Block Splinting of Volar Plate Injuries at Neutral Position
Authors: Stanley Edward A. , Seifman Marc A. , Mills Bernice , Fay Pearse , Thomas Damon J. 
Published: March 2019

Purpose
Volar plate injuries of the proximal interphalangeal joint (PIPJ) of a finger are common, often occurring in sporting or workplace incidents. Treatment of a stable dorsal dislocation entails a conservative approach, directed at preventing hyperextension and allowing the ligament to heal in position that does not negatively impact on healing. Current treatment regimens include dorsal block splinting (DBS) in 30° of flexion, which maintains the PIPJ in flexion in order to prevent any strain on the healing tissue while attempting to restore anatomical position. Recognized complications of DBS are flexion deformities of the joint and hyperextensibility. We propose that DBS in neutral position, rather than 30° flexion, reduces hyperextensibility as well as preventing flexion deformities of the PIPJ, allowing sooner return of function and participation in daily activities.

Methods
A retrospective review of patients sustaining volar plate injuries was undertaken. Inclusion criteria involved patients splinted at either 30° or neutral position, both those having undergone surgical or conservative regimens and the joint assessed as stable. Data were collected focusing on the number of hand therapy sessions, the time from injury to discharge, active angles of flexion and extension of the PIPJ, and pain.

Results
Over 2 years, 125 patients were treated for volar plate injuries: 20 with DBS at neutral position and 105 DBS at 30°. There were no significant differences in patient demographics. There were fewer hand therapy appointments required for those splinted in neutral position and weeks of hand therapy predischarge. There were no flexion deformities for patients undergoing DBS at neutral position, but no difference in PIPJ extension. There were no differences in hyperextensibility or pain.

Conclusions
Dorsal block splinting at neutral position results in fewer flexion deformities following volar plate injuries of the PIPJ, without resultant hyperextensibility. There are fewer demands on hand therapy. Dorsal block splinting at neutral position may result in better function for patients suffering this injury, with decreased complications and quicker return to daily activities.
Improved Adipocyte Viability in Autologous Fat Grafting With Ascorbic Acid–Supplemented Tumescent Solution
Authors: Lunger Alexander , Ismail Tarek , Todorov Atanas , Buergin Joel , Lunger Fabian , Oberhauser Ida , Haug Martin , Kalbermatten Daniel Felix , Largo Rene Denis , Martin Ivan , Scherberich Arnaud , Schaefer Dirk Johannes 
Published: March 2019

Introduction
In reconstructive surgery, fat volume augmentation is often necessary for esthetic or functional reasons. As an alternative to synthetic and xenogeneic materials, autologous fat grafting (AFG) based on liposuction is gaining popularity, yet successful transplantation and long-term volume maintenance are difficult. Standard tumescent solution formulations neglect adipocyte and stromal vascular fraction (SVF) cell survival during extraction, as well as SVF differentiation into adipocytes thereafter, all of which are crucial for the success of AFG. Here we hypothesized that addition of ascorbic acid (AA) to the tumescent solution could prevent liposuction-induced cell damage.

Materials and Methods
The effect of 0.1 mmol/L AA in tumescent solution was investigated in a previously described ex vivo model of AFG. Briefly, excision fat was infiltrated with tumescent solution, with or without AA, and incubated for 20 minutes at 37°C. Hand-assisted liposuction was then performed with a blunt cannula. Total cell viability, clonogenicity, and differentiation capacity of the SVF cells were assessed.

Results
With AA, 10.3% more cells and in particular 14.9% more adipocytes survived liposuction. Clonogenicity, adipocyte and osteoblast differentiation by SVF cells remained unchanged.

Conclusions
Addition of AA successfully improved survival of adipocytes during liposuction without affecting SVF growth and differentiation. This study therefore identified a useful supplement to the tumescent solution which may lead to improving AFG success.