bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alpha Traveling Waves during Working Memory: Disentangling Bottom-Up Gating and Top-Down Gain Control
Authors: Zeng Yifan , Sauseng Paul , Alamia Andrea 
Published: November 2024

While previous works established the inhibitory role of alpha oscillations during working memory maintenance, it remains an open question whether such an inhibitory control is a top-down process. Here, we attempted to disentangle this issue by considering the spatiotemporal component of waves in the alpha band, i.e., alpha traveling waves. We reanalyzed two pre-existing and open-access EEG datasets (
N
= 180, 90 males, 80 females, 10 unknown) where participants performed lateralized, visual delayed match-to-sample working memory tasks. In the first dataset, the distractor load was manipulated (2, 4, or 6), whereas in the second dataset, the memory span varied between 1, 3, and 6 items. We focused on the propagation of alpha waves on the anterior-posterior axis during the retention period. Our results reveal an increase in alpha-band forward waves as the distractor load increased, but also an increase in forward waves and a decrease in backward waves as the memory set size increased. Our results also showed a lateralization effect: alpha forward waves exhibited a more pronounced increase in the hemisphere contralateral to the distractors, whereas the reduction in backward waves was stronger in the hemisphere contralateral to the targets. In short, the forward waves were regulated by distractors, whereas targets inversely modulated backward waves. Such a dissociation of goal-related and goal-irrelevant physiological signals suggests the coexistence of bottom-up and top-down inhibitory processes: alpha forward waves might convey a gating effect driven by distractor load, while backward waves may represent direct top-down gain control of downstream visual areas.
Ocular lesions in systemic lupus erythematosus: An overview
Authors: Nallagula Unnathi , Kharel Ranju , Biswas Jyotirmay 
Published: November 2024

Systemic lupus erythematosus (SLE) is a life-threatening, multisystemic, chronic autoimmune disease. Ocular manifestations of SLE are diverse, affecting any part of the eye. It is a potentially blinding disease with ocular manifestations as the presenting feature. The prevalence of retinal involvement is estimated to be 3% to 29% and it tends to be bilateral and asymmetrical. Retinal signs often concur with the severity of systemic inflammation. Microangiopathy in SLE mimics diabetic and hypertensive retinopathy, moderately severe SLE can have presentation that mimic Purtscher-like retinopathy with a prevalence of 0.14%. Vaso-occlusive disease can either have isolated/combined, retinal artery or vein occlusion. Associated antiphospholipid antibody also increases the risk of vaso-occlusion. The occurrence of optic neuritis and ischemic optic neuropathy is rare in SLE. Presence of peripheral ulcerative keratitis, and scleral, orbital, retinal, choroidal, and neurological manifestations require immediate systemic therapy. Hydroxychloroquine >6.5 mg/kg for 5 years is associated with high risk of toxicity. Modern imaging techniques like fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) help in diagnosis and monitoring of disease activity.
ВЕГЕТАТИВНОЕ И СЕМЕННОЕ ПОТОМСТВО РЕДКИХ ФОРМ СОСНЫ СИБИРСКОЙ В КРАСНОЯРСКОЙ ЛЕСОСТЕПИ
Authors: Г.В. КУЗНЕЦОВА 
Published: November 2024

Представлены результаты исследования роста и генеративной структуры у вегетативного и семенного потомства редких форм сосны сибирской ( Pinus sibirica Du Tour) (кедра сибирского), созданных на территории опытного экспериментального хозяйства «Погорельский бор» в Красноярской лесостепи (Емельяновский район Красноярского края). Материнские деревья вегетативного потомства произрастают в оптимальных условиях для кедра сибирского в низкогорье Западного Саяна, семенного - в предгорье Хамар-Дабана бассейна оз. Байкал. Для редких форм деревьев кедра сибирского помимо двухлетнего семеношения характерно развитие мегастробил в год цветения, на год раньше, чем у типичных форм. По результатам исследования выявлено что вегетативное потомство кедра сибирского наследует однолетний и смешанный типы семеношения материнского дерева (808) саянской популяции; семенное потомство байкальской популяции выделяется по ростовым показателям (повышенным числом семядолей, длинной хвоей, числом латеральных побегов, высотой, приростом), характерным также для материнских деревьев. Выявленные признаки у вегетативного и семенного потомства кедра сибирского редких форм в Красноярской лесостепи характерны для гибридных растений, проявляющихся как гетерозис роста.
The results of a study of the biology of the development of vegetative and seed progeny of rare forms of the Siberian stone pine ( Pinus sibirica Du Tour), created under new testing conditions in the experimental forestry “Pogorelsky Bor” in the Krasnoyarsk forest-steppe, are presented. Mother trees of vegetative offspring grow in optimal conditions in the low mountains of the Western Sayan, and seed trees in the foothills of Khamar-Daban and the Lake Baikal basin. Rare forms of the Siberian stone pine trees are characterized, in addition to the two-year seeding period, by the development of megastrobiles in the year of flowering, a year earlier than in typical forms. According to the results of the study, it was revealed that the vegetative offspring of the Siberian stone pine inherits the annual and mixed type of seed production of the mother tree (808) of the Sayan population; The seed offspring of the Baikal population are distinguished by growth indicators (increased number of cotyledons, long needles, number of lateral shoots, height, growth), which are also characteristic of mother trees. All identified signs of vegetative and seed progeny of the Siberian stone pine rare forms created in the Krasnoyarsk forest-steppe are characteristic of hybrid plants, manifested as growth heterosis.
Discussing the challenges of Operational Experience Feedback processes from the perspective of Psychodynamics of Work
Authors: Kawasaki Bruno Cesar , Mascia Fausto Leopoldo 
Published: November 2024

Paper aims: Elucidating the barriers for an active participation of field workers in Operational Experience Feedback (OEF) processes and identifying potential ways forward.
Originality: Although the literature on OEF already addresses its challenges and strategies, we identified an opportunity for delving deeper into the (inter)subjective issues involved.
Research method: We conduct a review of the technical-scientific literature on OEF and elaborate a discussion in light of the theory of Psychodynamics of Work (PDW).
Main findings: Silence and disengagement in OEF can be the result of field workers and managers resorting to defensive strategies against the risks of questionings and critiques, which are nevertheless necessary for discussing and deliberating issues reported via OEF. The deliberation gap (i.e., the exclusion of field workers from deliberation of issues they report) can be an important element in the distrust and distance between field and management.
Implications for theory and practice: In order to strengthen OEF processes, we propose the development of collective resources that shall enable stakeholders dealing with questionings more constructively. For this purpose, we suggest strategies that consider the expectations on OEF results, performance evaluation criteria, and the conditions for field workers to participate in the deliberation of issues reported.
External Validation of an Electronic Health Record–Based Diagnostic Model for Histological Acute Tubulointerstitial Nephritis
Authors: Moledina Dennis G. , Shelton Kyra , Menez Steven , Aklilu Abinet M. , Yamamoto Yu , Kadhim Bashar A. , Shaw Melissa , Kent Candice , Makhijani Amrita , Hu David , Simonov Michael , O’Connor Kyle , Bitzel Jack , Thiessen-Philbrook Heather , Wilson F. Perry , Parikh Chirag R. 
Published: November 2024

Key Points

Individual noninvasive diagnostic tests lack accuracy for diagnosing histological acute tubulointerstitial nephritis.A validated diagnostic model combining four clinical tests accurately predicted acute tubulointerstitial nephritis on biopsy in two separate populations.

Background
Accurate diagnosis of acute tubulointerstitial nephritis (AIN) often requires a kidney biopsy. We previously developed a diagnostic statistical model for predicting biopsy-confirmed AIN by combining four laboratory tests after evaluating over 150 potential predictors from the electronic health record. In this study, we validate this diagnostic model in two biopsy-based cohorts at Johns Hopkins Hospital (JHH) and Yale University, which were geographically and temporally distinct from the development cohort, respectively.

Methods
We analyzed patients who underwent kidney biopsy at JHH and Yale University (2019–2023). We assessed discrimination (area under receiver-operating characteristics curve [AUC]) and calibration using previously derived model coefficients and recalibrated the model using an intercept correction factor that accounted for differences in baseline prevalence of AIN between development and validation cohorts.

Results
We included 1982 participants: 1454 at JHH and 528 at Yale. JHH (5%) and Yale (17%) had lower proportions of biopsies with AIN than the development set (23%). The AUC was 0.73 (95% confidence interval [CI], 0.66 to 0.79) at JHH and 0.73 (95% CI, 0.67 to 0.78) at Yale, similar to the development set (0.73 [95% CI, 0.64 to 0.81]). Calibration was imperfect in validation cohorts, particularly at JHH, but improved with the application of an intercept correction factor. The model increased AUC of clinicians’ prebiopsy suspicion for AIN by 0.10 to 0.77 (95% CI, 0.71 to 0.82).

Conclusions
An AIN diagnostic model retained discrimination in two validation cohorts but needed recalibration to account for local AIN prevalence. The model improved clinicians’ ability to predict AIN.
Subject relative clauses in Dagbani
Authors: Mursell Johannes , Hartmann Katharina 
Published: November 2024

This paper is concerned with subject relative clauses in Dagbani, a Mabia language spoken in northern Ghana, as these have received little attention in the literature compared to other relative clause constructions. We will argue that a successful syntactic analysis depends on a double headed relative clause structure, with one relative clause internal and one relative clause external head. In addition to discussing the syntax of an understudied language, the paper thus provides further evidence for relative clauses being based on double headed structures, at least in some languages.
Phenology and social status of the endemic Sable Island Sweat Bee, Lasioglossum sablense
Authors: Richards Miriam Helen , Lucas Zoe , Proulx Alex , Corbin Lyllian , Jacks Frederica , Kehler Dan 
Published: November 2024

Lasioglossum (Dialictus) sablense Gibbs, 2010 (Hymenoptera: Halictidae) is endemic to Sable Island, an isolated sandbar located about 160 km east of Nova Scotia, Canada. Lasioglossum sablense is currently listed as Threatened due to its restricted geographic distribution, and promoting its conservation requires detailed information about nesting phenology, behaviour, and other life history details. We combined measurements of body size, wear, and ovarian status from adult females collected from flowers in 2016 and 2017 with measurements and behavioural observations of foragers collected at the Sable Island Station in 2019 and 2022, to compile a preliminary description of flight phenology and social behaviour. Like many members of its genus, L. sablense exhibited a diphasic life history. Phase 1 began when large, fertilized adult females emerged from hibernation, began nest and brood cell construction, and foraged to provision Brood 1, which comprised both daughters and sons. Most nests initiated during Phase 1 reactivated during Phase 2, with adult Brood 1 daughters foraging to provision Brood 2. Observations of bees at nest entrances demonstrated that some reactivated nests contained multiple adult females. Phase 1 foragers were larger, less worn, and had marginally higher levels of ovarian development than Phase 2 foragers. Five large females collected during Phase 2 had high levels of wear, suggesting they were long-lived Phase 1 foundresses that resumed foraging during Phase 2. Taken together, these observations suggest a mix of univoltine (single generation) and bivoltine (two generation) life histories, as well as a mix of solitary and social behaviour in L. sablense.
Investigating the Prevalence of Malnutrition and Its Relationship with the Educational Status of Elementary School Students in Zahedan, Iran
Authors: Eslahi Hadi , Jamalzehi Atena , Mokhtari Somayeh , Moein Abbasali , Mortazavi Zinat 
Published: November 2024

Background: Malnutrition and improper nutrition may lead to physical and mental growth disorder and cognitive function. This study aims to determine the prevalence of malnutrition and its relationship with educational status among primary school children in Zahedan, Iran. Methods: During a cross-sectional study with a multi-stage random sampling method of 780 boy and girl students, first, second, and third grades of elementary school were included to study. Demographic and anthropometric of students were collected based on the sample size. Malnutrition was assessed according to World Health Organization indicators for the relevant age group. This assessment was based on body mass index (BMI) for age, height for age, and weight for age. Results: The prevalence of malnutrition was severe wasting, wasting, overweight, and obesity which were 0.8, 4.6, 6.4, and 5%, and severe underweight and underweight which were 0.9 and 4.7%, respectively. Severe stunting and stunting were observed in 0.3 and 2.8%, respectively. A statistically significant relationship was found between BMI for age, height for age and weight for age and educational status (P<0.05). Moreover, the educational status of students showed a statistically significant relationship with first and second-grade gender, birth rank, and Parent’s job and education (P<0.0001). Conclusion: Different forms of malnutrition among the students can negatively affect their performance, especially their educational status. Therefore, proper nutrition and increasing nutritional knowledge of primary school children and parents may help to prevent the problem.
PENGEMBANGAN SOAL TES FORMATIF MATEMATIKA GARIS DAN SUDUT BERBASIS ETNOMATEMATIKA RUMAH ADAT BUBUNGAN TINGGI
Authors: Sara Hilma , Pasani Chairil Faif , Amalia Rizki 
Published: November 2024

Penggunaan tes formatif dalam pembelajaran matematika termasuk kunci untuk mengukur dan meningkatkan pemahaman peserta didik secara berkelanjutan. Pengembangan tes formatif yang mengaitkan unsur budaya lokal seperti etnomatematika dari rumah adat Bubungan Tinggi masih sangat terbatas. Tujuan utama kajian ini ialah untuk memaparkan proses pengembangan soal tes formatif dengan memperhatikan aspek validitas serta reliabilitas sehingga menghasilkan soal tes formatif matematika yang reliabel dan valid yang bisa dipergunakan sebagai alat evaluasi pemahaman peserta didik terhadap materi garis dan sudut. Kajian ini mempergunakan metode Research and Development (R&D) atau penelitian pengembangan dengan model pengembangan tipe formative research. Uji coba ini dilaksanakan di MTs Negeri 2 Hulu Sungai Tengah dengan subjek penelitian untuk tahap one-to-one tiga orang peserta didik, untuk tahap small group enam orang peserta didik dan untuk tahap field test 35 orang peserta didik. Teknik pengumpulan data mempergunakan lembar angket respon peserta didik, lembar validasi dan 15 soal tes fomatif yang berbentuk pilihan ganda disertai dengan penyelesaiannya. Produk yang dikembangkan dinilai oleh dua orang validator ahli sehingga didapat skor validitas logis senilai 3,53 termasuk dalam kategori sangat valid. Uji validitas empiris butir soal didapat sembilan soal valid, enam soal tidak valid dan uji reliabilitas didapat skor 0,657 termasuk dalam kategori reliabilitas tinggi. Sehingga kajian ini menghasilkan sembilan soal tes formatif matematika materi garis dan sudut berbasis etnomatematika rumah adat Bubungan Tinggi untuk SMP/MTs yang valid dan reliabel.
AVALIAÇÃO DOS PARÂMETROS HEMATOLÓGICOS, PROTEÍNA C REATIVA E D-DÍMERO EM INDIVÍDUOS INFECTADOS PELO SARS COV-2
Authors: COELHO KÁTIA BERNARDES , PFRIMER IRMTRAUT ARACI HOFFMANN 
Published: November 2024

Durante a COVID-19, o sistema hematopoiético é afetado e alterado pela infecção sistêmica causada pelo vírus. Durante o curso da doença, neutrofilia, eosinofilia, trombocitopenia, níveis elevados de D-dímero e fibrinogênio e alterações morfológicas de leucócitos, eritrócitos e plaquetas podem ser observados. Este trabalho visa analisar as principais alterações hematológicas associadas à infecção por SARS-CoV-2, bem como a proteína C reativa (PCR) e o D-dímero em indivíduos com diagnóstico de COVID-19 leve e COVID-19 grave. Trata-se de uma pesquisa transversal analítica, utilizando-se de uma amostra com 40 indivíduos da cidade de Gurupi/TO, com infecção aguda. Os indivíduos participantes do estudo foram distribuídos em dois grupos: 20 pacientes sem internação hospitalar (casos leves) e 20 hospitalizados (casos graves). Os dados evidenciam que a COVID-19 se manifesta de forma mais grave em indivíduos com mais de 60 anos. Além disso, os níveis de D-dímero e PCR aumentaram significativamente nos indivíduos que tiveram COVID-19 grave. As alterações no hemograma se relacionaram com um aumento dos bastonetes e segmentados em relação à COVID-19 grave. Além disso, valores diminuídos na COVID-19 grave foram encontrados nas hemácias, hematócrito e hemoglobina. Conclui-se que há um claro padrão anormal de parâmetros hematológicos em pacientes graves com COVID-19. Os resultados dos exames de sangue são relevantes no prognóstico e acompanhamento do paciente com COVID-19.
Enhancing Glioblastoma Resection with Near-Infrared Fluorescence Imaging: A Systematic Review
Authors: Mansour Hadeel M , Shah Siddharth , Aguilar Tania M , Abdul-Muqsith Mohammed , Gonzales-Portillo Gabriel S , Mehta Ankit I 
Published: November 2024

Glioblastoma Multiforme (GBM) remains one of the most aggressive and challenging brain tumors to treat. Even with maximal treatment, the prognosis remains poor with low median survival. Extensive surgical resection is evidenced to increase glioblastoma life expectancy; however, complete resections are not usually achieved due to lack of sensitivity and the accuracy of margin neurosurgical guidance technologies. Recent advancements in fluorescence-guided surgery (FGS) and imaging techniques have helped enhance the precision and extent of glioblastoma resections. This study explores the impact of NIR fluorescence imaging on tumor visualization and surgical outcomes, including the extent of resection, cost-effectiveness, and patient survival.
A systematic search of PubMed, Scopus, Google Scholar, and Embase identified studies published on the effect of NIR on glioblastoma surgery. A total of 135 studies were included: 10 reviews, 3 clinical studies, 10 randomized controlled trials (RCTs), 10 preclinical studies, and 4 case reports, all focusing on the application of NIR fluorescence imaging in glioblastoma resection.
Our findings show that NIR fluorescence imaging significantly improved tumor visualization, leading to an 18-22% increase in gross total resection rates across clinical studies. Prolonged fluorescence provided continuous real-time feedback, reducing the need for repeat imaging, and lowering operational costs. Patient outcomes improved, including extended progression-free survival and overall survival, and fewer postoperative neurological deficits. This Review highlights the potential for the use of NIR imaging to become the new standard for intraoperative glioblastoma management.
Cytokines and Madness: A Unifying Hypothesis of Schizophrenia Involving Interleukin-22
Authors: Sfera Adonis , Thomas Kyle A. , Anton Jacob 
Published: November 2024

Schizophrenia is a severe neuropsychiatric illness of uncertain etiopathogenesis in which antipsychotic drugs can attenuate the symptoms, but patients rarely return to the premorbid level of functioning. In fact, with each relapse, people living with schizophrenia progress toward disability and cognitive impairment.
We hypothesize that poor outcomes in schizophrenia reflect gray matter volume reduction, which continues despite treatment. We further hypothesize that aryl hydrocarbon receptor phosphorylates signal transducer and transcription-three protein, suppressing the gut barrier protectors, including brain-derived neurotrophic factor and interleukin-22.
We construe that recombinant human IL-22 can improve schizophrenia outcome by the following actions:
1.	Averting microbial translocation outside the gastrointestinal tract by optimizing the gut barrier permeability.
2.	Upregulation of BDNF, a neurotrophin lowered in schizophrenia.
3.	Downregulation of interferon-gamma, a cytokine elevated in patients with schizophrenia.
4.	Acceleration of wound healing and long-term memory formation via STAT3-induced inflammatory responses.
This short review examines the influence of IL-22 and BDNF on the STAT3 /AhR axis. Based on the hypothesis described here, we discuss alternative SCZ interventions, including aryl hydrocarbon receptor antagonists, mitochondrial transplant, membrane lipid replacement, and recombinant human IL-22.
Significance of HBsAg Expression in Placental Tissue with Serum Positivity in Hepatitis B Virus-infected Mother
Authors: Kalatiku Jane Magdalena , J Nelwan Berti , Zainuddin Andi Alfian , Kaelan Cahyono , Achmad Djumadi , Masadah Rina 
Published: November 2024

Introduction: Hepatitis B virus infection in fetal and newborn may result from the intrauterine vertical transmission. The purpose of our study is to determine the association between HBsAg expression in the placental and HBsAg serum in pregnant women. Methods: Total 67 placental tissues and serum were obtained from HBV-infected mothers. This study was conducted in various hospitals in Makassar, Indonesia from December 2017 until August 2018. Maternal serum and placental tissues were tested by ELISA and Immunohistochemistry staining. Results: 67 samples from placental tissues and serum were categorized into two different levels of serum titer and staining positivity. Twenty nine samples (43.3%) were categorized in low titer of HBsAg positive serum and 38 samples (56.7%) in high titer of HBsAg positive serum. From the total of 67 placental samples, 43 (64.2%) samples had positive expression of HBsAg immunohistochemistry staining and 24 (34.8%) samples had negative expressions. Conclusions: There was a significant correlation between the expressions of HBsAg in the placental tissues and serum titers of HBV-infected mothers that is important in predicting the risk of transplacental transmission. The results of this study can be used as guidelines for the prevention and therapeutic approach of mother-to-child HBV infection.