bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing treatments for basal cell carcinoma in terms of long‐term treatment‐failure: a network meta‐analysis
Authors: Fukumoto T. , Fukumoto R. , Oka M. , Horita N. 
Published: July 2019

AbstractsAlthough many variations of guidelines have been released, there is limited research that compares multiple treatment strategies for basal cell carcinoma (BCC). The aim of this study was to systematically review the studies reporting on multiple treatments for BCC with systematic review and network meta‐analyses. Search formulas for databases, such as PubMed, EMBASE, Web of Science Core Collection and Cochrane Central Register of Controlled Trials, were created with the support of Cochrane Japan. The patient‐level and tumour‐level meta‐analyses were performed for both the long‐term treatment‐failure and treatment‐success. Of the 1464 studies identified from the database and hand searches, 14 met our inclusion criteria. These 14 studies included 2524 patients and 1738 tumours. Our study indicated that the incidence of treatment‐failure of invasive treatments such as surgery and Mohs micrographic surgery was significantly lower than that of superficial therapies such as cryotherapy, photodynamic therapy, radiotherapy or topical therapies, in the patient‐level and the tumour‐level analyses, despite histological‐type and pretreatment. Relapse of BCC may be a low life‐threatening risk, and there are merits of non‐surgical treatment. However, the significant difference in the recurrence rate is essential. Our study can provide useful guidance to clinicians in selecting treatment options for BCC.
In vivo evaluation of the effectiveness of biocellulose facial masks as active delivery systems to skin
Authors: Perugini Paola , Bleve Mariella , Redondi Renato , Cortinovis Fabiola , Colpani Antonio 
Published: July 2019

AbstractBackgroundIn recent years, bacterial cellulose (BC), or biocellulose, a natural polymer synthesized by certain bacteria, has attracted great interest in dermatology and cosmetic applications.Several bioactive ingredients are currently loaded into BC masks. However, only a few studies have reported the effectiveness of such delivery systems.AimThe aim of this study was to evaluate the effect on skin parameters of three biocellulose masks formulated to have different cosmetic effects (anti‐aging, lifting, and cell renewal). In particular, skin moisturizing, skin color, skin viscoelastic properties, skin surface smoothness, wrinkle reduction, dermal homogeneity, and stratum corneum renewal were evaluated.Materials and methodsThe study involved 69 healthy Caucasian female volunteers between 25 and 64 years, who were divided into three different studies. Biocellulose facial masks were applied using the split‐face method three times a week for 4‐8 weeks depending on the study.ResultsThe results obtained from this work highlight that biocellulose masks are very well tolerated. A significant decrease in skin roughness and wrinkle breadth, and an improvement in dermal homogeneity and firmness, was observed after 2 months of treatment with “anti‐aging” masks. A significant improvement in skin firmness and elasticity was observed after 1 month of treatment with “lifting” masks. Furthermore, a 1‐month treatment with “cell renewal” masks promoted the production of new skin cells through a mild exfoliating action.ConclusionsThis study highlights that biocellulose masks are effective delivery systems to successfully release into the skin several types of active compounds exerting many beneficial effects.
Autologous fat transfer for facial recontouring in Parry‐Romberg syndrome
Authors: Kasielska‐Trojan Anna , Zieliński Tomasz , Antoszewski Bogusław 
Published: July 2019

AbstractBackgroundParry‐Romberg syndrome (PRS) is a rare condition involving self‐limited progressive facial hemiatrophy.AimsTo analyze esthetic results of fat graft used for correcting soft‐tissues atrophy in PRS patients, in the aspect of volume restoration and skin rejuvenation, to present our experience in redefining facial contours in PRS and modification of fat graft accusation technique (based on Coleman's technique).Patients/MethodsA prospective evaluation study was designed to analyze esthetic results (contour and skin condition), complications, and subjective satisfaction of eight patients with PRS treated with fat graft.ResultsAll patients underwent two (n = 6) or three (n = 2) procedures in 3 months intervals (the mean 3.7 months). No major postoperative complications were observed. The authors evaluated their esthetic results concerning face contour and symmetry as good (in four patients) and very good (in four patients). Subjective assessment showed high patients’ satisfaction with the final result of face contouring (the mean VAS [0‐5]‐4.75).ConclusionsOur experience shows that fat grafting in patients with PRS is safe and gives satisfactory results in the aspect of volume restoration and skin quality improvement. Modified technique of graft preparation (112 g for 3 minutes) enables to obtain less dense fat graft, which is more appropriate in case of PRS patients with thin atrophic skin.
Allergen components in diagnosing childhood hazelnut allergy: Systematic literature review and meta‐analysis
Authors: Nilsson Caroline , Berthold Malin , Mascialino Barbara , Orme Michelle , Sjölander Sigrid , Hamilton Robert 
Published: July 2019

AbstractBackgroundHazelnut‐specific IgE antibodies (sIgEs) in serum support the diagnosis of hazelnut allergy, but extract‐based tests have low diagnostic specificity, commonly leading to over‐diagnosis. Measuring sensitization to individual allergen components may enhance the diagnosis of hazelnut allergy. We systematically examined data on diagnostic accuracy of sIgE to commercially available hazelnut components to compare their individual contributions in diagnosing hazelnut allergy.MethodsSeven databases were searched for diagnostic studies on patients suspected of having hazelnut allergy. Studies employing component‐specific IgE testing on patients whose final diagnosis was determined by oral food challenges were included in the meta‐analysis. Study quality was assessed as recommended by Cochrane.ResultsSeven cross‐sectional studies and one case‐control study were identified, seven presenting data on children (N = 635), and one on a mixed age population. Overall, the diagnostic accuracies of sIgE to both Cor a 9 and Cor a 14 were significantly higher than for Cor a 1‐sIgE (P < .05). In children, the specificity of Cor a 14‐sIgE at 0.35 kUA/L cutoff was 81.7% (95% CI 77.1, 85.6), and 67.3% (60.3, 73.6) for Cor a 9‐sIgE. The specificities for Cor a 1‐sIgE and hazelnut‐sIgE were 22.5% (7.4, 51.2) and 10.8% (3.4, 29.8), respectively. The sensitivity of Cor a 1‐sIgE (60.2% [46.9, 72.2]) was lower than for hazelnut extract‐sIgE (95.7% [88.7, 98.5]), while their specificities did not differ significantly.ConclusionsIgE to Cor a 14 and Cor a 9 hazelnut storage proteins increases diagnostic specificity in assessing hazelnut allergy in children. The combined use of hazelnut extract and hazelnut storage proteins may improve diagnostic value.
The weirdness of having a bunch of other minds like yours in the room: The lived experiences of mentalization‐based therapy for borderline personality disorder
Authors: Gardner Kathryn Jane , Wright Karen M. , Elliott Alison , Graham Simon , Fonagy Peter 
Published: July 2019

ObjectivesStudies of lived experiences are important for improving treatment effectiveness, but most studies of mentalization‐based therapy (MBT) are quantitative. This qualitative study aimed to better understand service users’ lived experiences of MBT, including their experiences of change.DesignThis is a qualitative study that used one‐to‐one semi‐structured interviews.MethodSemi‐structured interviews were conducted with eight MBT service users recruited via four NHS trusts. Interviews were analysed using interpretative phenomenological analysis (IPA).FindingsThree superordinate themes were identified: being borderline, being in the group, and being on a journey. ‘Experiences of diagnosis’ and ‘the group’ are salient topics in the lived experiences of service users’ during the MBT journey, as is the nature/type of ‘change’ that can create symptom reduction albeit alongside a negative felt experience.ConclusionOur research aligns with current thought regarding the complexity and challenges of treating BPD via psychotherapy and adds a further dimension, that of experiencing MBT and changes during therapy. The participants’ experiences of BPD and of experiencing MBT are discussed.Practitioner points

Therapists are observant of how each client gives meaning to their experience of diagnosis, the group, and change, particularly since the experience of recovery is not all positive.

Service users’ emerging and ongoing construction of their experience of diagnosis is closely monitored and additional appropriate strategies implemented where necessary.

The impact of joining MBT, especially the group, becomes a process for formal regular review.

Therapists undertake an in‐depth exploration of service users’ felt experiences to capture less quantifiable dimensions of change.
Concurrent Business and Buyer–Supplier Behavior in B2B Auctions: Evidence from Truckload Transportation
Authors: Scott Alex 
Published: July 2019

Buyers often procure distinct goods and services from the same supplier. Accordingly, business exchanged in one setting may affect exchanges between the buyer and supplier in other settings. We study how business procured via online business‐to‐business (B2B) auctions is affected by business exchanged between the buyer and supplier concurrent to the auctions (concurrent business). Using two transactional datasets, one with auctions held by a large buyer of transportation services over a 4‐year period and another with the buyer's transactions with suppliers over the same time period but governed by long‐term contracts, we analyze whether the contractual business affects decisions made in the auctions. We find that the buyer's auction–invitation decisions are affected by a supplier's auction performance and the presence and magnitude of the concurrent business relationship, showing that relationships still matter when buyers use online B2B auctions for procurement. After the concurrent relationship ends, auction invitations eventually cease; this effect, however, is moderated by the supplier's performance in the auctions. Concurrent business also affects supplier decisions in the form of reference prices. When a buyer and supplier have a preexisting price for the service up for auction, the supplier at times substitutes that for their bid price, with considerable heterogeneity explained by a supplier's business model, market conditions, and the recent usage of the contract price in the concurrent relationship. The business relationship external to a B2B auction significantly affects the decisions made within an auction through multiple mechanisms.
Left ventricular geometry correlates with early repolarization pattern in adolescent athletes
Authors: Miragoli Michele , Goldoni Matteo , Demola Pierluigi , Paterlini Arianna , Li Calzi Mauro , Gioia Margherita Ilaria , Visioli Francesco , Rossi Stefano , Pelà Giovanna 
Published: July 2019

Some forms of early ECG repolarization QRS pattern (ERp) with J‐point elevation of 0.1 mV in two contiguous inferior and/or lateral leads with or without ST‐elevation are potentially associated with a higher arrhythmic risk in adults. We assessed the prevalence of ERp among non‐professional adolescent athletes and correlated it with age, sex, ethnicity, and structural and electric cardiac parameters. We retrospectively analyzed 414 ECGs obtained from young athletes referred to our center from 2006 to 2017. We found ERp in 22% of cases. In the ERp group, we found a greater percentage of black athletes, a higher systolic blood pressure, and lower heart rate (HR) compared with the group without ERp. This pattern was less frequent in female athletes. In athletes with ERp, the occurrence of ventricular ectopic beats was less frequent and QRS‐duration was shorter. They also exhibited greater (a) ECG‐based left ventricular hypertrophy (LVH), (b) left ventricular mass, and (c) relative wall thickness (RWT), suggesting a tendency to concentric geometry. At logistic regression analysis, we found that HR (OR 0.98 [0.96‐0.99] P = .013), QRS‐duration (OR 0.96 [0.94‐0.99], P = .003), LVH (OR 1.09 [1.05‐1.12], P < .001), and RWT (OR 1.08 [1.01‐1.16] P = .032) were significant predictors of ERp incidence. ERp is quite common in adolescent athletes and correlates with concentric LV remodeling. Specific clinical and ECG‐findings related to training such as lower HR, LVH, and QRS‐duration are also predictors of ERp. In adolescent non‐professional athletes, ERp is a benign finding associated with some structural and electric cardiac modifications induced by training.
Topic Subjects in Brazilian Portuguese and Clitic Left Dislocation in Dominican Spanish: The Role of Clitics and Null Subjects
Authors: Kato Mary A. , Ordóñez Francisco 
Published: July 2019

AbstractBrazilian Portuguese used to have null subjects like European Portuguese, but today they are mostly lost. It has been claimed that this change to the null‐subject parameter made Brazilian Portuguese no longer a subject‐prominent language (aka an agreement‐prominent language) but a topic‐and‐subject‐prominent one, with the appearance of so‐called topic subjects. In this article, we show that the loss of null subjects in Brazilian Portuguese is not sufficient to explain the emergence of topic subjects: the generalized loss of third‐person clitics also plays a crucial role. We provide evidence from within Brazilian Portuguese, comparing topic‐subject constructions to clitic‐left‐dislocation constructions with first‐ and second‐person pronouns; we also compare Brazilian Portuguese to Dominican Spanish, a language that has also mostly lost null subjects but has retained its entire clitic system. We show that what is behind the appearance of topic‐subject constructions in Brazilian Portuguese is the partial disappearance of clitic left dislocation, a topic construction that Dominican Spanish has retained for all persons. The analysis proposed appeals to empty dative clitics and their inability to assign case in Brazilian Portuguese. Finally, we adopt the feature‐inheritance hypothesis (Miyagawa 2010) in order to derive the topicality of Brazilian Portuguese's so‐called topic subjects.
Methotrexate exposure and risk of strongyloidiasis
Authors: Richards Ceri , Penner Justin , Colmegna Ines , Loewen Hal , Melaku Zenebe , Melkie Addisu , Meltzer Michele , Scuccimarri Rosie , Mengistu Yewondwossen , Hitchon Carol A. 
Published: July 2019

AbstractObjectiveRheumatologic disease patients receiving immunomodulating drugs such as methotrexate (MTX) have increased infection rates. Strongyloides, a global endemic intestinal parasite, can cause significant or fatal disease in immunocompromised patients. The risk of serious Strongyloides infection with MTX dosed for rheumatologic disease is unknown.MethodsWe performed a systematic literature review searching EMBASE, Medline and Web of Science databases. All studies reporting humans exposed to MTX and tested for Strongyloides were reviewed. Exclusion criteria were bone marrow transplantation, intrathecal route and MTX exposure completed >1 year prior to clinically apparent Strongyloides disease.ResultsAfter excluding duplicates, 294 articles were reviewed. Of these, 29 cases were described in 27 papers. Twenty cases (69%) had an underlying rheumatologic or dermatologic disease, the rest had a haematologic disease. Hyperinfection or dissemination was found in 59% of cases (52% low‐dose MTX; 75% high‐dose MTX). Death occurred in 34% of cases (19% low‐dose MTX; 75% high‐dose MTX, P < 0.01). All eight patients on high‐dose MTX received other immunosuppressants. Corticosteroids were taken in 18/21 patients on low‐dose MTX. One of the three patients on MTX monotherapy had hyperinfection syndrome. None had disseminated Strongyloides.ConclusionsSerious Strongyloides infection can occur with low‐dose MTX particularly when given with other immunosuppression. Global travel and greater awareness of rheumatologic conditions in low‐ to middle‐income countries will increase the exposure of individuals prescribed MTX (with or without corticosteroids) to Strongyloides. Strongyloides screening and treatment should be considered for individuals receiving low‐dose MTX therapy, particularly if combined with additional immunosuppression.
Equidistant combination wavelength screening and step-by-step phase-out method for the near-infrared spectroscopic analysis of serum urea nitrogen
Authors: Yang Yihui , Lei Fenfen , Zhang Jing , Yao Lijun , Chen Jiemei , Pan Tao 
Published: July 2019

We applied near-infrared (NIR) spectroscopy with chemometrics for the rapid and reagent-free analysis of serum urea nitrogen (SUN). The modeling is based on the average effect of multiple sample partitions to achieve parameter selection with stability. A multiparameter optimization platform with Norris derivative filter–partial least squares (Norris-PLS) was developed to select the most suitable mode [Formula: see text], [Formula: see text], [Formula: see text]. Using equidistant combination PLS (EC-PLS) with four parameters (initial wavelength [Formula: see text], number of wavelengths [Formula: see text], number of wavelength gaps [Formula: see text] and latent variables LV), we performed wavelength screening after eliminating high-absorption wavebands. The optimal EC-PLS parameters were [Formula: see text][Formula: see text]nm, [Formula: see text], [Formula: see text] and [Formula: see text]. The root-mean-square error (SEP), correlation coefficient [Formula: see text] for prediction and ratio of performance-to-deviation (RPD) for validation were 1.03[Formula: see text]mmol[Formula: see text]L[Formula: see text], 0.992 and 7.6, respectively. We proposed the wavelength step-by-step phase-out PLS (WSP-PLS) to remove redundant wavelengths in the top 100 EC-PLS models with improved prediction performance. The combination of 19 wavelengths was identified as the optimal model for SUN. The SEP, [Formula: see text] and RPD in validation were 1.01[Formula: see text]mmol[Formula: see text]L[Formula: see text], 0.992 and 7.7, respectively. The prediction effect and wavelength complexity were better than those of EC-PLS. Our results showed that NIR spectroscopy combined with the EC-PLS and WSP-PLS methods enabled the high-precision analysis of SUN. WSP-PLS is a secondary optimization method that can further optimize any wavelength model obtained through other continuous or discrete strategies to establish a simple and better model.
The Distribution of Dissolved Methane and Its Air-Sea Flux in the Plume of a Seep Field, Lingtou Promontory, South China Sea
Authors: Di Pengfei , Feng Dong , Chen Duofu 
Published: July 2019

Methane (CH4), the most abundant hydrocarbon gas in the atmosphere, plays an important role in global climate change. Quantifying the dissolved methane and its air-sea flux from hydrocarbon seeps is therefore of great importance. Large quantities of natural gas are emitted from the seafloor to the coastal ocean near the Lingtou Promontory, South China Sea. We quantified concentrations of methane in surface and bottom waters at 48 stations in a 56 km2 study area. High spatial variability in dissolved methane concentrations was observed in the surface mixed layer (0.5 m water depth) and bottom water (water-sediment interface), with values ranging from 2.90 nmol L−1 to 13570.02 nmol L−1 and from 4.98 nmol L−1 to 31740.02 nmol L−1, respectively. The significant difference between concentrations of dissolved methane in surface and bottom waters suggests that most of the methane emitted from the seafloor is dissolved in the water column. The dissolution of methane in seawater may result in local oxygen depletion that may lead to ecological effects. The δ13C values of dissolved methane ranging from −59.76‰ to −48.59‰ indicate a mixture of biogenic and thermogenic gas sources. The average air-sea methane flux of Yinggehai Basin was 672.57 μmol m−2 d−1, which cannot be ignored in environment assessment. Coastal regions, especially with hydrocarbon seeps in shallow waters of the continental margin, may therefore be an important source of methane to the atmosphere.
The Workers’ Opposition and the Specialists
Authors: Allen Barbara C. 
Published: July 2019

Abstract
While Vladimir Lenin found it necessary to depend upon and support technical and managerial specialists who had been trained in pre-revolutionary educational institutions, the Bolsheviks were never comfortable with this dependency. Under Iosif Stalin, the specialists were vilified, persecuted, marginalized, and eventually replaced by highly specialized technical personnel trained in Soviet educational institutions. This article examines the attitudes toward specialists held by leading members of the Workers’ Opposition, a group of communist trade union leaders who promoted the economic management role of workers through their trade unions. In Western secondary literature, the stance of the Workers’ Opposition toward specialists is sometimes misunderstood or oversimplified. In correcting such errors, I will show that Stalin’s motivations for repression directed against engineers and technicians during the First Five-Year Plan should be sought elsewhere than in the attempt to expand the role and prominence of workers in the party bureaucracy and industrial administration of the new Soviet state.
Revising the ‘Trotskyist’ Opposition of the Bolshevik Party in 1923–1924
Authors: Reznik Alexander 
Published: July 2019

Abstract
In 1923–1924 the Bolshevik Party experienced political conflict that took the form of a public confrontation between two trends related to issues of intra-party practice and economic policies. This essay examines the Left Opposition in the Bolshevik party, which is widely known as the Trotskyist Opposition; yet was not a unified faction led by Lev Trotsky, but a heterogeneous and informal movement in support of democratic reform in the party. The problem of party, government, and economic leadership led to friction and then a split in the party in 1926–1928. The majority of the Central Committee and the Opposition became the ideological and organizational core of the trends which combined into stable or situational coalitions.
NEP’s Last Stand
Authors: Wynn Charters 
Published: July 2019

Abstract
Forced collectivization and breakneck industrialization, with all their attendant hardships and suffering, as well as the brutal terror that followed, could have been prevented if the defenders of NEP within the Party leadership had been able to block Joseph Stalin and his supporters’ drive to power. In mid-1928, when Stalin was gaining the advantage over those soon to be labeled Right Deviationists, he considered Mikhail Tomsky and the trade unions the major obstacles to his plans to abandon NEP and push forward with forced collectivization and breakneck industrialization. The final showdown between the Stalinists and trade-union leadership occurred at the 8th Trade Union Congress, which met in December 1928. The broad outline of Tomsky’s defeat at the congress has long been known, but this episode remains largely unexplored. Examining how Stalin outmaneuvered Tomsky during 1928, and whether the trade unionists went down without a fight at the congress, is the focus of this article.