bluuebunny/crossref_metadata_2025_split huggingface dataset:
The scars of youth: Effects of early‐career unemployment on future unemployment experience
Authors: SCHMILLEN Achim , UMKEHRER Matthias 
Published: March 2018

AbstractDoes early‐career unemployment cause future unemployment? The authors approach this question using German administrative matched employer–employee data that track almost 700,000 individuals over 24 years. Instrumenting early‐career unemployment with firm‐specific labour demand shocks, they find significant and long‐lasting “scarring effects”. In the mean, each additional day of unemployment during the first eight years on the labour market increases unemployment in the following 16 years by half a day. However, quantile regressions show that the scarring effects are much stronger for individuals who already suffer from lengthy and repeated spells of unemployment.
Molecular control of B‐cell homeostasis in health and malignancy
Authors: Garcillán Beatriz , Figgett William A , Infantino Simona , Lim Ee Xin , Mackay Fabienne 
Published: March 2018

AbstractAltered B‐cell homeostasis underlies a wide range of pathologies, from cancers to autoimmunity and immunodeficiency. The molecular safeguards against those disorders, which also allow effective immune responses, are therefore particularly critical. Here, we review recent findings detailing the fine control of B‐cell homeostasis, during B‐cell development, maturation in the periphery and during activation and differentiation into antibody‐producing cells.
Enterovirus D‐68 in children presenting for acute care in the hospital setting
Authors: Savage Timothy J. , Kuypers Jane , Chu Helen Y. , Bradford Miranda C. , Buccat Anne Marie , Qin Xuan , Klein Eileen J. , Jerome Keith R. , Englund Janet A. , Waghmare Alpana 
Published: March 2018

BackgroundSevere respiratory disease associated with enterovirus D68 (EV‐D68) has been reported in hospitalized pediatric patients. Virologic and clinical characteristics of EV‐D68 infections exclusively in patients presenting to a hospital Emergency Department (ED) or urgent care have not been well defined.MethodsMid‐nasal swabs from pediatric patients with respiratory symptoms presenting to the ED or urgent care were evaluated using a commercial multiplex PCR platform. Specimens positive for rhinovirus/enterovirus (HRV/EV) were subsequently tested using real‐time reverse‐transcriptase PCR for EV‐D68. The PCR cycle threshold (CT) was used as a viral load proxy. Clinical outcomes were compared between patients with EV‐D68 and patients without EV‐D68 who tested positive for HRV/EV.ResultsFrom August to December 2014, 511 swabs from patients with HRV/EV were available. EV‐D68 was detected in 170 (33%) HRV/EV‐positive samples. In multivariable models adjusted for age and underlying asthma, patients with EV‐D68 were more likely to require hospitalization for respiratory reasons (odds ratio (OR): 3.11, CI: 1.85‐5.25), require respiratory support (OR: 1.69, CI: 1.09‐2.62), have confirmed/probable lower respiratory tract infection (LRTI; OR: 3.78, CI: 2.03‐7.04), and require continuous albuterol or steroids (OR: 3.91, CI: 2.22‐6.88 and OR: 4.73, CI: 2.65‐8.46, respectively). Higher EV‐D68 viral load was associated with need for respiratory support and LRTI in multivariate models.ConclusionsAmong pediatric patients presenting to the ED or urgent care, EV‐D68 causes more severe disease than non‐EV‐D68 HRV/EV independent of underlying asthma. High viral load was associated with worse clinical outcomes. Rapid and quantitative viral testing may help identify and risk stratify patients.
X‐ray photoelectron spectroscopy analysis of Ge–Sb–Se pulsed laser deposited thin films
Authors: Baudet Emeline , Cardinaud Christophe , Boidin Rémi , Girard Aurélie , Gutwirth Jan , Němec Petr , Nazabal Virginie 
Published: March 2018

AbstractPulsed laser deposition was used to prepare amorphous thin films from (GeSe2)100−x(Sb2Se3)x system (x = 0, 5, 10, 20, 30, 40, 50, and 60). From a wide variety of chalcogenide glass‐forming systems, Ge–Sb–Se one, especially in thin films form, already proved to offer a great potential for photonic devices such as chemical sensors. This system has a large glass‐forming region which gives the possibility to adjust the chemical composition of the glasses according to required physical characteristics. The chemical composition of fabricated thin films was analyzed via X‐ray photoelectron spectroscopy (XPS) and compared to energy dispersive spectroscopy (EDS) data. The results of both techniques agree well: a small deficiency in chalcogen element and an excess of antimony was found. The structure of as‐deposited thin films has been investigated by XPS. The presence of the two main structural units, [GeSe4] and [SbSe3] proposed by Raman scattering spectroscopy data analysis, was confirmed by XPS. Moreover, XPS core level spectra analysis revealed the presence of M–M bonds (M = Ge, Sb) in (Ge,Sb)–Ge–(Se)3 and (Ge,Sb)–Sb–(Se)2 entities that could correspond to Ge‐based tetrahedra and Sb‐based pyramids where one of its Se atoms at corners is substituted by Ge or Sb ones. The content of depicted M–M bonds tends to increase with introduction of antimony in the amorphous network of as‐deposited thin films from x = 0 to x = 40 and then it decreases. XPS analysis of as‐deposited thin films shows also the presence of the (Ge,Sb)–Se–(Ge,Sb) and Se–Se–(Ge,Sb) entities.
The role of emotions in predicting sperm and egg donation
Authors: Shepherd Lee , Kardzhieva Dimana , Bussey Lauren , Lovell Brian 
Published: March 2018

AbstractSperm and egg donation allows people who cannot have children naturally to become parents. However, in many countries there is a shortage of donors. Therefore, it is important to assess the factors that influence donation. Across two studies, we assessed the role of social‐cognitive and emotional factors in promoting and deterring sperm and egg donation. Study 1 (N = 138 men) found that feeling anxiety toward discovering a fertility problem and pride positively predicted sperm donation intention and information seeking behavior. By contrast, feeling anxiety toward the process of donation negatively predicted sperm donation intention and information seeking behavior. Study 2 (N = 193 women) found that pride positively and the anxiety toward the process negatively predicted egg donation intentions, but not information seeking behavior. These results suggest that it is important to consider the role of emotions in motivating and deterring people from becoming a sperm and egg donor.
The transcription factor Dach1 is essential for podocyte function
Authors: Endlich Nicole , Kliewe Felix , Kindt Frances , Schmidt Katharina , Kotb Ahmed M. , Artelt Nadine , Lindenmeyer Maja T. , Cohen Clemens D. , Döring Franziska , Kuss Andreas W. , Amann Kerstin , Moeller Marcus J. , Kabgani Nazanin , Blumenthal Antje , Endlich Karlhans 
Published: March 2018

AbstractDedifferentiation and loss of podocytes are the major cause of chronic kidney disease. Dach1, a transcription factor that is essential for cell fate, was found in genome‐wide association studies to be associated with the glomerular filtration rate. We found that podocytes express high levels of Dach1 in vivo and to a much lower extent in vitro. Parietal epithelial cells (PECs) that are still under debate to be a type of progenitor cell for podocytes expressed Dach1 only at low levels. The transfection of PECs with a plasmid encoding for Dach1 induced the expression of synaptopodin, a podocyte‐specific protein, demonstrated by immunocytochemistry and Western blot. Furthermore, synaptopodin was located along actin fibres in a punctate pattern in Dach1‐expressing PECs comparable with differentiated podocytes. Moreover, dedifferentiating podocytes of isolated glomeruli showed a significant reduction in the expression of Dach1 together with synaptopodin after 9 days in cell culture. To study the role of Dach1 in vivo, we used the zebrafish larva as an animal model. Knockdown of the zebrafish ortholog Dachd by morpholino injection into fertilized eggs resulted in a severe renal phenotype. The glomeruli of the zebrafish larvae showed morphological changes of the glomerulus accompanied by down‐regulation of nephrin and leakage of the filtration barrier. Interestingly, glomeruli of biopsies from patients suffering from diabetic nephropathy showed also a significant reduction of Dach1 and synaptopodin in contrast to control biopsies. Taken together, Dach1 is a transcription factor that is important for podocyte differentiation and proper kidney function.
Precision medicine in diabetes prevention, classification and management
Authors: Xie Fangying , Chan Juliana CN , Ma Ronald CW 
Published: March 2018

AbstractDiabetes has become a major burden of healthcare expenditure. Diabetes management following a uniform treatment algorithm is often associated with progressive treatment failure and development of diabetic complications. Recent advances in our understanding of the genomic architecture of diabetes and its complications have provided the framework for development of precision medicine to personalize diabetes prevention and management. In the present review, we summarized recent advances in the understanding of the genetic basis of diabetes and its complications. From a clinician's perspective, we attempted to provide a balanced perspective on the utility of genomic medicine in the field of diabetes. Using genetic information to guide management of monogenic forms of diabetes represents the best‐known examples of genomic medicine for diabetes. Although major strides have been made in genetic research for diabetes, its complications and pharmacogenetics, ongoing efforts are required to translate these findings into practice by incorporating genetic information into a risk prediction model for prioritization of treatment strategies, as well as using multi‐omic analyses to discover novel drug targets with companion diagnostics. Further research is also required to ensure the appropriate use of this information to empower individuals and healthcare professionals to make personalized decisions for achieving the optimal outcome.
Phenotypic integration in an extended phenotype: among‐individual variation in nest‐building traits of the alfalfa leafcutting bee (Megachile rotundata)
Authors: Royauté Raphaël , Wilson Elisabeth S. , Helm Bryan R. , Mallinger Rachel E. , Prasifka Jarrad , Greenlee Kendra J. , Bowsher Julia H. 
Published: March 2018

AbstractStructures such as nests and burrows are an essential component of many organisms’ life‐cycle and require a complex sequence of behaviours. Because behaviours can vary consistently among individuals and be correlated with one another, we hypothesized that these structures would (1) show evidence of among‐individual variation, (2) be organized into distinct functional modules and (3) show evidence of trade‐offs among functional modules due to limits on energy budgets. We tested these hypotheses using the alfalfa leafcutting bee, Megachile rotundata, a solitary bee and important crop pollinator. Megachile rotundata constructs complex nests by gathering leaf materials to form a linear series of cells in pre‐existing cavities. In this study, we examined variation in the following nest construction traits: reproduction (number of cells per nest and nest length), nest protection (cap length and number of leaves per cap), cell construction (cell size and number of leaves per cell) and cell provisioning (cell mass) from 60 nests. We found a general decline in investment in cell construction and provisioning with each new cell built. In addition, we found evidence for both repeatability and plasticity in cell provisioning with little evidence for trade‐offs among traits. Instead, most traits were positively, albeit weakly, correlated (r ~ 0.15), and traits were loosely organized into covarying modules. Our results show that individual differences in nest construction are detectable at a level similar to that of other behavioural traits and that these traits are only weakly integrated. This suggests that nest components are capable of independent evolutionary trajectories.
Correlated evolution of thermal niches and functional physiology in tropical freshwater fishes
Authors: Culumber Zachary W. , Tobler Michael 
Published: March 2018

AbstractThe role of ecology in phenotypic and species diversification is widely documented. Nonetheless, numerous nonadaptive processes can shape realized niches and phenotypic variation in natural populations, complicating inferences about adaptive evolution at macroevolutionary scales. We tested for evolved differences in thermal tolerances and their association with the realized thermal niche (including metrics describing diurnal and seasonal patterns of temperature extremes and variability) across a genus of tropical freshwater fishes reared in a standardized environment. There was limited evolution along the thermal niche axis associated with variation in maximum temperature and in upper thermal limits. In contrast, there was considerable diversification along the first major axis of the thermal niche associated with minimum temperatures and in lower thermal limits. Across our adaptive landscape analyses, 70% of species exhibited evidence of divergence in thermal niches. Most importantly, the first two major axes of thermal niche variation were significantly correlated with variation in lower thermal limits. Our results indicate adaptation to divergent thermal niches and adaptive evolution of related functional traits, and highlight the importance of divergence in lower thermal limits for the evolution of tropical biodiversity.
Facing financialization: The divergent mutations of agricultural cooperatives in postapartheid South Africa
Authors: Ducastel Antoine , Anseeuw Ward 
Published: March 2018

AbstractThis paper analyses the transformation of the South African (former) grain cooperatives since 1994. These entities played a key role in the institutional architecture of the apartheid regime, ensuring the domination of white commercial farmers over the sector. Within the framework of the deregulation of the economy and the agricultural sector, such entities faced transformations of modern capitalism, especially the growing power of financial actors and markets. Although white commercial farmers still largely retain these inherited structures, these companies are presently being targeted more and more by private takeovers and/or private equity deals. Based on two specific empirical examples of private equity deals affecting South African grain cooperatives, this paper describes this financialization process in practice, in particular by analysing the interaction between financial and agricultural actors and the alliances on the ground that determine its “success.” In doing so, it details the different trajectories of these (former) cooperatives, highlighting the resilience, mutation, and extinction of commercial agriculture in South Africa.
The Advertisement of Alcohol in Colonial and Post‐Colonial Times in Southern Nigeria
Authors: Okonkwo Uche Uwaezuoke 
Published: March 2018

AbstractUntil the arrival of Europeans to the coast of Africa, indigenous alcohol brands were heavily consumed. The arrival of Europeans with foreign alcohol brands came with heavy advertisement focusing on the idea of modernity. Although the people did not abandon indigenous consumption of alcohol, imported alcohol brands became a yardstick for measuring class and thus created a new form of identity not previously in existence.
Associations between informant ratings of personality disorder traits, self‐reports of personality, and directly observed behavior
Authors: Kaurin Aleksandra , Sauerberger Kyle S. , Funder David C. 
Published: March 2018

AbstractObjectiveDiagnoses of personality disorders (PD) must rely on judgments of observers—either clinicians or acquaintances—because personality disorders are primarily defined in terms of maladaptive interpersonal behavior. Little is known, however, about how closely acquaintances' judgments of PD traits relate to self‐reports of theoretically relevant Big Five traits or directly observed behavioral outcomes in interpersonal situations. The present study examines associations between judgments of the 10 PD traits provided by close acquaintances, self‐reports of PD‐relevant Big Five personality traits, and observed interpersonal behaviors across three different three‐person laboratory interactions (i.e., unstructured chat, cooperative task, competitive game).MethodThe sample consisted of 256 undergraduate students (130 females; Mage = 19.83, SD = 1.25). Four unacquainted observers independently rated participants' behaviors from video recordings.ResultsIn line with previous work, informant reports of PD traits demonstrate strong convergent validity with relevant self‐reported Big Five traits (as identified by Lynam & Widiger, 2001). Directly observed behavior is meaningfully associated with acquaintances' judgments and self‐reports of PD‐relevant traits, and the associations between these judgments and behavior are strongest for traits associated with histrionic and schizoid PD. Vector correlations between behavioral profiles associated with informant and self‐reports show that both assessments have similar behavioral correlates. Associations between PD trait ratings and behavior appeared to differ as a function of gender, with males showing more and stronger correlations.ConclusionsInformants' ratings of PD traits are impressively accurate, converging both with self‐reports of relevant traits and directly observed interpersonal behavior. Therefore, a comprehensive understanding of PDs and associated traits can be augmented by information from multiple acquaintances who have the opportunity to observe how an individual interacts with others on a daily basis across diverse contexts.
Consistency and stability of narrative coherence: An examination of personal narrative as a domain of adult personality
Authors: Waters Theodore E. A. , Köber Christin , Raby K. Lee , Habermas Tilmann , Fivush Robyn 
Published: March 2018

AbstractObjectiveNarrative theories of personality assume that individual differences in coherence reflect consistent and stable differences in narrative style rather than situational and event‐specific differences (e.g., McAdams & McLean, 2013). However, this assumption has received only modest empirical attention. Therefore, we present two studies testing the theoretical assumption of a consistent and stable coherent narrative style.MethodStudy 1 focused on the two most traumatic and most positive life events of 224 undergraduates. These event‐specific narratives were coded for three coherence dimensions: theme, context, and chronology (NaCCs; Reese et al., 2011). Study 2 focused on two life narratives told 4 years apart by 98 adults, which were coded for thematic, causal, and temporal coherence (Köber, Schmiedek, & Habermas, 2015).ResultsConfirmatory factor analysis in both studies revealed that individual differences in the coherence ratings were best explained by a model including both narrative style and event‐/narration‐specific latent variables.ConclusionsThe ways in which we tell autobiographical narratives reflect a stable feature of individual differences. Further, they suggest that this stable element of personality is necessary, but not sufficient, in accounting for specific event and life narrative coherence.
Gender Expression, Violence, and Bullying Victimization: Findings From Probability Samples of High School Students in 4 US School Districts
Authors: Gordon Allegra R. , Conron Kerith J. , Calzo Jerel P. , White Matthew T. , Reisner Sari L. , Austin S. Bryn 
Published: March 2018

ABSTRACTBACKGROUNDYoung people may experience school‐based violence and bullying victimization related to their gender expression, independent of sexual orientation identity. However, the associations between gender expression and bullying and violence have not been examined in racially and ethnically diverse population‐based samples of high school students.METHODSThis study includes 5469 students (13–18 years) from the 2013 Youth Risk Behavior Surveys conducted in 4 urban school districts. Respondents were 51% Hispanic/Latino, 21% black/African American, 14% white. Generalized additive models were used to examine the functional form of relationships between self‐reported gender expression (range: 1 = Most gender conforming, 7 = Most gender nonconforming) and 5 indicators of violence and bullying victimization. We estimated predicted probabilities across gender expression by sex, adjusting for sexual orientation identity and potential confounders.RESULTSStatistically significant quadratic associations indicated that girls and boys at the most gender conforming and nonconforming ends of the scale had elevated probabilities of fighting and fighting‐related injury, compared to those in the middle of the scale (p < .05). There was a significant linear relationship between gender expression and bullying victimization; every unit increase in gender nonconformity was associated with 15% greater odds of experiencing bullying (p < .0001).CONCLUSIONSSchool‐based victimization is associated with conformity and nonconformity to gender norms. School violence prevention programs should include gender diversity education.
Teacher Victimization in Authoritative School Environments
Authors: Kapa Ryan R. , Luke Jeremy , Moulthrop Dorothy , Gimbert Belinda 
Published: March 2018

ABSTRACTBACKGROUNDVictimization in schools is not limited to students. Teachers increasingly face threats and attacks from their students. An authoritative school environment, characterized by high structure and support, has been associated with lower rates of victimization. The purpose of this study was to explore the relationship between authoritative school environments and teacher victimization rates.METHODSResearchers examined public school teacher responses (N = 37,497) from the Schools and Staffing Survey regarding rules and issues facing the school community. Descriptive statistics were gathered, and a hierarchical regression technique was employed to assess the impact of a structured, supportive school environment on teacher victimization.RESULTSResults indicate an authoritative school environment helped reduce rates of teacher victimization. White, female teachers are among the teachers most likely to experience violence from students. Enforcing school rules, by both teachers and administrators, is the most effective way to diminish episodes of teacher victimization.CONCLUSIONSP‐12 school personnel should emphasize the importance of enforcing school rules and reducing negative issues, such as student truancy and apathy within each school. As high levels of structure and support reduce instances of violence, these findings have important implications for school environments and teacher health.