bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adherence to a Dietary Approaches to Stop Hypertension (DASH)-type diet over the life course and associated vascular function: a study based on the MRC 1946 British birth cohort
Authors: Maddock Jane , Ziauddeen Nida , Ambrosini Gina L. , Wong Andrew , Hardy Rebecca , Ray Sumantra 
Published: March 2018

AbstractLittle is known about long-term associations between the Dietary Approaches to Stop Hypertension (DASH) diet and conventional cardiovascular (CV)-risk factors as well as novel measures of vascular function. This study aimed to examine whether long-term adherence to a DASH-type diet in a British birth cohort is associated with conventional CV-risk factors and two vascular function markers, carotid intima–media thickness (cIMT) and pulse wave velocity (PWV). Data came from 1409 participants of the Medical Research Council (MRC) National Survey of Health and Development. Dietary intake was assessed at 36, 43, 53 and 60–64 years using 5-d estimated food diaries. The DASH-type diet score was calculated using the Fung index. Conventional CV-risk factors (blood pressure (BP) and lipids), cIMT in the right and/or left common carotid artery and PWV was measured when participants were 60–64 years. Associations between the DASH-type diet score and outcomes were assessed using multiple regression models adjusted for socioeconomic position, BMI, smoking and physical activity. Participants in higher sex-specific quintiles (Q) of the long-term DASH-type diet had lower BP (P≤0·08), higher HDL-cholesterol (P<0·001) and lower TAG (P<0·001) compared with people in Q1. Participants in Q5 of the long-term DASH-type diet had lower PWV (−0·28sd; 95 % CI −0·50, −0·07,Ptrend=0·01) and cIMT (−0·24sd; 95 % CI −0·44, −0·04,Ptrend=0·02) compared with participants in the Q1. This association was independent of the conventional CV-risk factors. Greater adherence to a DASH diet over the life course is associated with conventional CV-risk factors and independently associated with cIMT and PWV.
WOMEN’S EMPOWERMENT AND INTIMATE PARTNER VIOLENCE IN BANGLADESH: INVESTIGATING THE COMPLEX RELATIONSHIP
Authors: Sanawar Saifa Binte , Islam Mohammad Amirul , Majumder Shankar , Misu Farjana 
Published: March 2018

SummaryThe aim of this study was to assess whether women’s empowerment ensures reduced intimate partner violence (IPV). The differential relationship between women’s empowerment and IPV among married women in Bangladesh was investigated using 2007 Demographic and Health Survey data. Logistic regression models were used to assess whether women’s empowerment had any influence on their likelihood of experiencing IPV while controlling for other covariates. The analyses revealed that older cohorts of women, who were more empowered, were more vulnerable to physical violence than less-empowered, younger women. The likelihood of being affected by physical violence among less-empowered, childless women was greater than that of more-empowered women with only male children. Less-empowered, uneducated women were more likely to experience physical violence than more-empowered, primary-educated women. Less-empowered women who had been married for less than 5 years were more likely to suffer from physical violence than more-empowered women who had been married for more than 19 years. The likelihood of experiencing sexual violence was not found to have any significant association with women’s empowerment. The findings suggest that although women’s empowerment in Bangladesh is gradually improving, some sub-groups of empowered women are still susceptible to IPV.
Poison-Ivy/Poison-Oak/Poison-Sumac—The Virulent Weeds
Authors: Mitich Larry W. 
Published: March 2018

The word poison entered the English language in 1387 as ‘poysoun”, and in Memoirs of American Academy of Arts and Sciences, v. 1, 1785, the word poison-ivy was used for the first time: “Poison ivy … produces the same kind of inflammation and eruptions … as poison wood tree”.The first known reference to poison-ivy, Toxicodendron radicans (L.) Ktze., dates from the 7th century in China and the 10th century in Japan. Since Toxicodendron species do not grow in Europe, the plants remained unknown to Western civilization until explorers visited the New World seven centuries later. Capt. John Smith (1579–1631) wrote the first description of poison-ivy and originated its common name; he noted a similarity in the climbing habit of North American poison-ivy to English ivy (Hedera helix L.).
“Unhitching the Oxcart of Delhi”: a Mughal-Period Hindi account of Political Insurgency
Authors: BUSCH ALLISON 
Published: March 2018

AbstractThis article is part of a larger effort to broaden the source-base for understanding Mughal-period India by engaging with the Hindi literary archive. I analyze the vignettes of Aurangzeb and other Mughal figures that are available in Lāl Kavi's Chatraprakāś (Light of Chatrasal, c. 1710), a Brajbhasha (classical Hindi) historical poem commissioned by the Bundela ruler Chatrasal (1649–1731). Written shortly after Aurangzeb's death, the Chatraprakāś is in part a retrospective on Aurangzeb's reign. It is also a valuable source of regional history that gives voice to how the Mughal Empire was perceived from a local court that went in and out of political favour. In places, Lāl Kavi engages in trenchant political critique, expressing the court's strong disillusionment with the Mughal manṣabdārī system as well as more local grievances. While by no means the dominant tone of the work, there are occasional hints of the court's outrage at Mughal offenses against what Lal Kavi explicitly terms “Hindu dharma.” Parsing the Chatraprakāś as both poetry and history, I probe the text's complex perspectives on Mughal rule.
Can wild lentil genotypes help improve water use and transpiration efficiency in cultivated lentil?
Authors: Gorim Linda Yuya , Vandenberg Albert 
Published: March 2018

AbstractClimate change forecasts point to increased frequency of droughts which may affect plant growth. For protein crops such as lentil, genetic improvement of both water use and drought tolerance is necessary. Wild lentil species are known to have evolved in drought prone areas and can be introgressed into cultivated lentil, making them candidates for the evaluation of high transpiration efficiency (TE) and drought tolerance. We assessed TE, water use and drought tolerance at the plant level for five wild lentil species and in cultivated lentil. Under fully watered and moderate drought conditions, wild lentil genotypes consumed significantly less water to fix similar or more dry matter compared with their cultivated counterparts. Under severe drought conditions, the wild lentil genotype L. ervoides IG 72815 had significantly higher TE compared with L. culinaris Eston. Lens ervoides L-01-827A, had significantly higher yield compared with all other species in the presence or absence of drought and showed significantly higher (α = 5%) TE under moderate drought. Drought susceptibility index was identified as a tool to identify drought-tolerant lentil genotypes grown under severe drought. The numerous small seeds of wild lentil made it difficult to estimate drought indices that are weight based and require formulae that incorporate seed numbers.
Preemergence and Postemergence Control of Perilla Mint (Perilla frutescens): Avoiding Toxicity to Livestock
Authors: Russell David P. , Byrd John D. , Zaccaro Maria Leticia M. 
Published: March 2018

AbstractPRE and POST herbicide options were evaluated to control perilla mint, a potentially deadly plant for livestock. The germination requirements of seed from weedy populations were also investigated to better understand and predict emergence timing. POST applications of aminocyclopyrachlor blends, glyphosate, picloram+2,4-D, aminopyralid+2,4-D, and 2,4-D alone provided superior control of perilla mint when applied in the early reproductive growth stage. Picloram+2,4-D and aminocyclopyrachlor+chlorsulfuron also provided soil residual activity and the most effective PRE control followed by pendimethalin and aminopyralid+2,4-D. Seed from weedy populations tend to germinate in a range of night/day soil temperatures from 10–15 C to 25–30 C. Therefore, application and activation of the most effective PRE treatments should be made before these temperatures occur in areas where weedy perilla mint populations are found.
MiR34 inhibition induces human heart progenitor proliferation
Authors: Iannolo Gioacchin , Sciuto Maria Rita , Raffa Giuseppe Maria , Pilato Michele , Conaldi Pier Giulio 
Published: March 2018

AbstractMiR34 involvement in myocardial injury repair and ageing has been well documented in mouse model. Our aim was to establish whether the inhibition of miR34 expression through locked nucleic acid (LNA) could be used as a pharmacological intervention to enhance human heart repair. Cardiac progenitor cells were obtained by right atrial specimen collection during intraoperative procedures. Our analysis revealed a direct correlation between miR34 expression and patient age, and its silencing by LNA promoted the cardiac progenitor growth rate up to twofold ( ± 0.8). Our results confirmed the relevance of miR34a in human heart ageing, as previously demonstrated in mouse. Moreover, the decrease of miR34 expression in the cardiac progenitor cell population indicates its role in maintaining an undifferentiated status and consequently in a lower proliferation rate with the involvement of genes such as Notch-1, Numb, and p63.
Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
Authors: Patel Nirmesh , Weekes Daniel , Drosopoulos Konstantinos , Gazinska Patrycja , Noel Elodie , Rashid Mamun , Mirza Hasan , Quist Jelmar , Brasó-Maristany Fara , Mathew Sumi , Ferro Riccardo , Pereira Ana Mendes , Prince Cynthia , Noor Farzana , Francesch-Domenech Erika , Marlow Rebecca , de Rinaldis Emanuele , Grigoriadis Anita , Linardopoulos Spiros , Marra Pierfrancesco , Tutt Andrew N. J. 
Published: March 2018

AbstractTriple negative breast cancers (TNBCs) lack recurrent targetable driver mutations but demonstrate frequent copy number aberrations (CNAs). Here, we describe an integrative genomic and RNAi-based approach that identifies and validates gene addictions in TNBCs. CNAs and gene expression alterations are integrated and genes scored for pre-specified target features revealing 130 candidate genes. We test functional dependence on each of these genes using RNAi in breast cancer and non-malignant cells, validating malignant cell selective dependence upon 37 of 130 genes. Further analysis reveals a cluster of 13 TNBC addiction genes frequently co-upregulated that includes genes regulating cell cycle checkpoints, DNA damage response, and malignant cell selective mitotic genes. We validate the mechanism of addiction to a potential drug target: the mitotic kinesin family member C1 (KIFC1/HSET), essential for successful bipolar division of centrosome-amplified malignant cells and develop a potential selection biomarker to identify patients with tumors exhibiting centrosome amplification.
Development of the social brain from age three to twelve years
Authors: Richardson Hilary , Lisandrelli Grace , Riobueno-Naylor Alexa , Saxe Rebecca 
Published: March 2018

AbstractHuman adults recruit distinct networks of brain regions to think about the bodies and minds of others. This study characterizes the development of these networks, and tests for relationships between neural development and behavioral changes in reasoning about others’ minds (‘theory of mind’, ToM). A large sample of children (n = 122, 3–12 years), and adults (n = 33), watched a short movie while undergoing fMRI. The movie highlights the characters’ bodily sensations (often pain) and mental states (beliefs, desires, emotions), and is a feasible experiment for young children. Here we report three main findings: (1) ToM and pain networks are functionally distinct by age 3 years, (2) functional specialization increases throughout childhood, and (3) functional maturity of each network is related to increasingly anti-correlated responses between the networks. Furthermore, the most studied milestone in ToM development, passing explicit false-belief tasks, does not correspond to discontinuities in the development of the social brain.
Ultrafast optically induced ferromagnetic/anti-ferromagnetic phase transition in GdTiO3 from first principles
Authors: Khalsa Guru , Benedek Nicole A. 
Published: March 2018

AbstractEpitaxial strain and chemical substitution have been the workhorses of functional materials design. These static techniques have shown immense success in controlling properties in complex oxides through the tuning of subtle structural distortions. Recently, an approach based on the excitation of an infrared active phonon with intense midinfrared light has created an opportunity for dynamical control of structure through special nonlinear coupling to Raman phonons. We use first-principles techniques to show that this approach can dynamically induce a magnetic phase transition from the ferromagnetic ground state to a hidden antiferromagnetic phase in the rare earth titanate GdTiO3 for realistic experimental parameters. We show that a combination of a Jahn–Teller distortion, Gd displacement, and infrared phonon motion dominate this phase transition with little effect from the octahedral rotations, contrary to conventional wisdom.
General Prediction of Peptide-MHC Binding Modes Using Incremental Docking: A Proof of Concept
Authors: Antunes Dinler A. , Devaurs Didier , Moll Mark , Lizée Gregory , Kavraki Lydia E. 
Published: March 2018

AbstractThe class I major histocompatibility complex (MHC) is capable of binding peptides derived from intracellular proteins and displaying them at the cell surface. The recognition of these peptide-MHC (pMHC) complexes by T-cells is the cornerstone of cellular immunity, enabling the elimination of infected or tumoral cells. T-cell-based immunotherapies against cancer, which leverage this mechanism, can greatly benefit from structural analyses of pMHC complexes. Several attempts have been made to use molecular docking for such analyses, but pMHC structure remains too challenging for even state-of-the-art docking tools. To overcome these limitations, we describe the use of an incremental meta-docking approach for structural prediction of pMHC complexes. Previous methods applied in this context used specific constraints to reduce the complexity of this prediction problem, at the expense of generality. Our strategy makes no assumption and can potentially be used to predict binding modes for any pMHC complex. Our method has been tested in a re-docking experiment, reproducing the binding modes of 25 pMHC complexes whose crystal structures are available. This study is a proof of concept that incremental docking strategies can lead to general geometry prediction of pMHC complexes, with potential applications for immunotherapy against cancer or infectious diseases.
Loss and gain of N-linked glycosylation sequons due to single-nucleotide variation in cancer
Authors: Fan Yu , Hu Yu , Yan Cheng , Goldman Radoslav , Pan Yang , Mazumder Raja , Dingerdissen Hayley M. 
Published: March 2018

AbstractDespite availability of sequence site-specific information resulting from years of sequencing and sequence feature curation, there have been few efforts to integrate and annotate this information. In this study, we update the number of human N-linked glycosylation sequons (NLGs), and we investigate cancer-relatedness of glycosylation-impacting somatic nonsynonymous single-nucleotide variation (nsSNV) by mapping human NLGs to cancer variation data and reporting the expected loss or gain of glycosylation sequon. We find 75.8% of all human proteins have at least one NLG for a total of 59,341 unique NLGs (includes predicted and experimentally validated). Only 27.4% of all NLGs are experimentally validated sites on 4,412 glycoproteins. With respect to cancer, 8,895 somatic-only nsSNVs abolish NLGs in 5,204 proteins and 12,939 somatic-only nsSNVs create NLGs in 7,356 proteins in cancer samples. nsSNVs causing loss of 24 NLGs on 23 glycoproteins and nsSNVs creating 41 NLGs on 40 glycoproteins are identified in three or more cancers. Of all identified cancer somatic variants causing potential loss or gain of glycosylation, only 36 have previously known disease associations. Although this work is computational, it builds on existing genomics and glycobiology research to promote identification and rank potential cancer nsSNV biomarkers for experimental validation.
Spatio-temporal dynamics of soil bacterial communities as a function of Amazon forest phenology
Authors: Buscardo Erika , Geml József , Schmidt Steven K. , Freitas Helena , da Cunha Hillândia Brandão , Nagy Laszlo 
Published: March 2018

AbstractMost tropical evergreen rain forests are characterised by varying degrees of precipitation seasonality that influence plant phenology and litterfall dynamics. Soil microbes are sensitive to soil water:air ratio and to nutrient availability. We studied if within-year seasonality in precipitation and litterfall-derived nutrient input resulted in predictable seasonal variation in soil bacterial diversity/microbial functional groups in an Amazonian forest. We characterised the spatio-temporal dynamics of microbial communities from the plot to the stand scales and related them to precipitation seasonality and spatial variability in soil characteristics. Community composition and functional diversity showed high spatial heterogeneity and was related to variability in soil chemistry at the stand level. Large species turnover characterised plot level changes over time, reflecting precipitation seasonality-related changes in soil nutrient and moisture regimes. The abundance of decomposers was highest during the rainy season, characterised also by anaerobic saprophytes and N2-fixers adapted to fluctuating redox conditions. In contrast, Beijerinckiaceae, likely derived from the phyllosphere, were found at higher abundances when litter inputs and accumulation were highest. We showed that in a mildly seasonal rain forest, the composition of soil microbial communities appears to be following canopy phenology patterns and the two are interlinked and drive soil nutrient availability.
Feasibility and patient acceptability of a novel artificial intelligence-based screening model for diabetic retinopathy at endocrinology outpatient services: a pilot study
Authors: Keel Stuart , Lee Pei Ying , Scheetz Jane , Li Zhixi , Kotowicz Mark A. , MacIsaac Richard J. , He Mingguang 
Published: March 2018

AbstractThe purpose of this study is to evaluate the feasibility and patient acceptability of a novel artificial intelligence (AI)-based diabetic retinopathy (DR) screening model within endocrinology outpatient settings. Adults with diabetes were recruited from two urban endocrinology outpatient clinics and single-field, non-mydriatic fundus photographs were taken and graded for referable DR ( ≥ pre-proliferative DR). Each participant underwent; (1) automated screening model; where a deep learning algorithm (DLA) provided real-time reporting of results; and (2) manual model where retinal images were transferred to a retinal grading centre and manual grading outcomes were distributed to the patient within 2 weeks of assessment. Participants completed a questionnaire on the day of examination and 1-month following assessment to determine overall satisfaction and the preferred model of care. In total, 96 participants were screened for DR and the mean assessment time for automated screening was 6.9 minutes. Ninety-six percent of participants reported that they were either satisfied or very satisfied with the automated screening model and 78% reported that they preferred the automated model over manual. The sensitivity and specificity of the DLA for correct referral was 92.3% and 93.7%, respectively. AI-based DR screening in endocrinology outpatient settings appears to be feasible and well accepted by patients.
High-sensitivity optical to microwave comparison with dual-output Mach-Zehnder modulators
Authors: Endo Mamoru , Shoji Tyko D. , Schibli Thomas R. 
Published: March 2018

AbstractWe demonstrate the use of two dual-output Mach-Zehnder modulators (DO-MZMs) in a direct comparison between a femtosecond (fs) pulse train and a microwave signal. Through balanced detection, the amplitude-to-phase modulation (AM-PM) conversion effect is suppressed by more than 40 dB. A cross-spectrum technique enables us to achieve a high-sensitivity phase noise measurement (−186 dBc/Hz above 10-kHz offset), which corresponds to the thermal noise of a +9 dBm carrier. This method is applied to compare a 1-GHz fs monolithic laser to a 1-GHz microwave signal generated from photodetection of a free-running 500 MHz mode-locked laser. The measured phase noise is −160 dBc/Hz at 4-kHz, −167 dBc/Hz at 10-kHz, and −180 dBc/Hz at offset frequencies above 100-kHz. The measurement is limited by the free-running 500-MHz laser’s noise, the flicker noise of the modified uni-traveling carrier photodiode and the thermal noise floor, not by the method itself. This method also has the potential to achieve a similar noise floor even at higher carrier frequencies.
Haplotype-based allele mining in the Japan-MAGIC rice population
Authors: Ogawa Daisuke , Yamamoto Eiji , Ohtani Toshikazu , Kanno Noriko , Tsunematsu Hiroshi , Nonoue Yasunori , Yano Masahiro , Yamamoto Toshio , Yonemaru Jun-ichi 
Published: March 2018

AbstractMulti-parent advanced generation inter-cross (MAGIC) lines have broader genetic variation than bi-parental recombinant inbred lines. Genome-wide association study (GWAS) using high number of DNA polymorphisms such as single-nucleotide polymorphisms (SNPs) is a popular tool for allele mining in MAGIC populations, in which the associations of phenotypes with SNPs are investigated; however, the effects of haplotypes from multiple founders on phenotypes are not considered. Here, we describe an improved method of allele mining using the newly developed Japan-MAGIC (JAM) population, which is derived from eight high-yielding rice cultivars in Japan. To obtain information on the haplotypes in the JAM lines, we predicted the haplotype blocks in the whole chromosomes using 16,345 SNPs identified via genotyping-by-sequencing analysis. Using haplotype-based GWAS, we clearly detected the loci controlling the glutinous endosperm and culm length traits. Information on the alleles of the eight founders, which was based on the effects of mutations revealed by the analysis of next-generation sequencing data, was used to narrow down the candidate genes and reveal the associations between alleles and phenotypes. The haplotype-based allele mining (HAM) proposed in this study is a promising approach to the detection of allelic variation in genes controlling agronomic traits in MAGIC populations.