bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mode II Fracture of an Elastic-Plastic Sandwich Layer
Authors: Martínez-Pañeda Emilio , Cuesta I. Iván , Fleck Norman A. 
Published: September 2019

AbstractThe shear strength of a pre-cracked sandwich layer is predicted, assuming that the layer is linear elastic or elastic-plastic, with yielding characterized either by the J2 plasticity theory or by a strip-yield model. The substrates are elastic and of dissimilar modulus to that of the layer. Two geometries are analyzed: (i) a semi-infinite crack in a sandwich layer, subjected to a remote mode II K-field and (ii) a center-cracked sandwich plate of finite width under remote shear stress. For the semi-infinite crack, the near-tip stress field is determined as a function of elastic mismatch, and crack tip plasticity is either prevented (the elastic case) or duly accounted for (the elastic-plastic case). Analytical and numerical solutions are then obtained for the center-cracked sandwich plate of the finite width. First, a mode II K-calibration is obtained for a finite crack in the elastic sandwich layer. Second, the analysis is extended to account for crack tip plasticity via a mode II strip-yield model of finite strength and finite toughness. The analytical predictions are verified by finite element simulations, and a failure map is constructed in terms of specimen geometry and crack length.
Photoreceptor morphology and correlation with subretinal fluid chronicity associated with choroidal nevus
Authors: Yaghy Antonio , Yu Michael D , Dalvin Lauren A , Mazloumi Mehdi , Ferenczy Sandor R , Shields Carol L 
Published: September 2019

BackgroundSubretinal fluid (SRF) can be associated with choroidal nevus and can cause progressive change in the morphology of overlying photoreceptors.MethodsA retrospective observational study was performed using optical coherence tomography to assess nevus and SRF features, as well as photoreceptor morphology over time.ResultsThere were 232 choroidal nevi that presented with or developed SRF. Photoreceptor morphology at presentation was classified as normal (n=60, 26%), shaggy (elongated) (n=73, 31%), retracted (stalactite appearance) (n=76, 33%), or absent (n=23, 10%). There was a progression in photoreceptor morphology with increasing SRF chronicity (p=0.003). For nevus presenting with normal photoreceptors and later developed SRF (n=60), photoreceptors became shaggy in 29 (48%), retracted in 24 (40%), and absent in 7 (12%) after 15, 19 and 22 months, respectively. For nevus presenting with SRF and shaggy photoreceptors (n=73), progression to retracted photoreceptors occurred in 31 (42%) after a mean of 22 months; for nevus with SRF and retracted photoreceptors (n=76), progression to absent photoreceptors occurred in 19 (25%) after a mean of 34 months; and for nevus with absent photoreceptors (n=23), photoreceptor morphology showed no change after mean follow-up of 33 months. Risk of nevus growth to melanoma was not associated with photoreceptor morphology at presentation (p=0.19).ConclusionIn eyes with choroidal nevus and SRF, there is a longitudinal evolution in photoreceptor morphology from normal to shaggy to retracted then absent with increasing SRF chronicity. SRF chronicity, as indicated by photoreceptor morphology on presentation, did not correlate with nevus growth to melanoma.
Effects of stored whole rice bran treated with organic acids on the performance, nutrient digestibility, intestinal mucosa morphometry, and bone characteristics of broiler chickens
Authors: Gopinger E. , Xavier E.G. , Ziegler V. , Lopes D.C.N. , Krabbe E.L. , Nunes A.P. , Elias M.C. 
Published: September 2019

This study evaluated the effects of feeding whole rice bran (WRB) stored for different times and treated with a mixture of organic acids on the growth performance, nutrient digestibility, duodenal morphometry, and bone characteristics of broiler chickens. Three hundred and twenty 1-d-old Cobb broilers were used in a 21 d experiment with a completely randomized design. Whole rice bran with five storage times (0, 30, 60, 90, and 120 d) was included at a 12% level in the diets, with eight replicates of eight birds each. A polynomial regression with a significance level of 5% was used. A reduction in daily weight gain was observed in birds fed WRB stored up to 90 d. A quadratic response was observed in the daily feed intake and average body weight of birds fed diets containing WRB treated with a mixture of organic acids and stored up to 90 d. There was a linear increase in the digestibility of crude protein with increased WRB storage time. Apparent metabolizable energy and apparent metabolizable energy corrected for nitrogen showed an increasing quadratic response for up to 60 d of WRB storage and treated with a mixture of organic acids. A quadratic response for the morphometry of intestinal crypts was found. The crypt depth increased as the birds were fed a diet containing WRB treated with a mixture of organic acids, stored up to 30 d and decreased with storage times. In conclusion, WRB treated with a mixture of acetic and propionic acids and stored up to 60 d may be safely added to broiler chicken diets.
Effective theories of two T-dual theories are also T-dual
Authors: Davidović Ljubica , Sazdović Branislav 
Published: September 2019

Abstract
We investigate how T-duality and solving the boundary conditions of the open bosonic string are related. We start by considering the T-dualization of the open string moving in the constant background. We take that the coordinates of the initial theory satisfy either Neumann or Dirichlet boundary conditions. It follows that the coordinates of T-dual theory satisfy exactly the opposite set of boundary conditions. We treat the boundary conditions of both theories as constraints, and apply the Dirac procedure to them, which results in forming $$\sigma $$σ-dependent constraints. We solve these constraints and obtain the effective theories for the solution. We show that the effective closed string theories are also T-dual.
Lifetime estimations from RHIC Au+Au data
Authors: Kasza Gábor , Csörgő Tamás 
Published: September 2019

We discuss a recently found family of exact and analytic, finite and accelerating, [Formula: see text]-dimensional solutions of perfect fluid relativistic hydrodynamics to describe the pseudorapidity densities and longitudinal HBT-radii and to estimate the lifetime parameter and the initial energy density of the expanding fireball in Au[Formula: see text]+[Formula: see text]Au collisions at RHIC with [Formula: see text] GeV and 200 GeV colliding energies. From these exact solutions of relativistic hydrodynamics, we derive a simple and powerful formula to describe the pseudorapidity density distributions in high-energy proton–proton and heavy-ion collisions, and derive the scaling of the longitudinal HBT radius parameter as a function of the pseudorapidity density. We improve upon several oversimplifications in Bjorken’s famous initial energy density estimate, and apply our results to estimate the initial energy densities of high-energy reactions with data-driven pseudorapidity distributions. When compared to similar estimates at the LHC energies, our results indicate a surprising and nonmonotonic dependence of the initial energy density on the energy of heavy-ion collisions.
Auditor-Provided Tax Services and Accounting for Tax Uncertainty
Authors: Watrin Christoph , Burggraef Stephan , Weiss Falko 
Published: September 2019

This paper investigates the associations of auditor-provided tax services (APTS) with tax planning and audit quality using a German sample. Our findings differ from those of previous U.S. studies, which we attribute to the fact that prior to 2015, the International Financial Reporting Standards (IFRS) did not contain a clear regulation similar to FIN 48, which requires firms to reserve for tax uncertainties. We find for our IFRS sample a negative association between APTS and tax avoidance, which suggests that auditors are aware that firms might not reserve for tax uncertainties and may advise more conservative tax strategies. Additionally, we find a positive relation between the level of APTS and the sustainability of tax strategies in client firms, consistent with this conservative approach. Furthermore, our results show that APTS are positively related to audit quality for our sample. This finding suggests that auditors, being aware of remaining tax uncertainties that are not reserved for, are more reluctant to accept earnings management, which would further increase the risk of restatement. Taken together, the results of our study suggest the importance of accounting standards regarding tax uncertainties for the implications of APTS.
How to do a naked presentation
Authors: Yaffe Philip 
Published: September 2019

Each "Communication Corner" essay is self-contained; however, they build on each other. For best results, before reading this essay and doing the exercise, go to the first essay "How an Ugly Duckling Became a Swan," then read each succeeding essay.
A "naked" presentation solely relies upon good storytelling. Learn how to enrapture an audience without the use of visual aids.
PEG10 Promoter–Driven Expression of Reporter Genes Enables Molecular Imaging of Lethal Prostate Cancer
Authors: Shapovalova Mariya , Lee John K. , Li Yingming , Vander Griend Donald J. , Coleman Ilsa M. , Nelson Peter S. , Dehm Scott M. , LeBeau Aaron M. 
Published: September 2019

Abstract

The retrotransposon-derived paternally expressed gene 10 (PEG10) protein is ordinarily expressed at high levels in the placenta. Recently, it was discovered that PEG10 isoforms promote the progression of prostate cancer to a highly lethal androgen receptor (AR)-negative phenotype. The presence of PEG10 in other subtypes of prostate cancer has not been explored and a utility for PEG10 overexpression has not been developed. Here, we found that in addition to AR-null disease, PEG10 was also expressed in prostate cancer with constitutively active AR-splice variants. A molecular genetic imaging strategy for noninvasive imaging of AR-splice variant prostate cancer was developed by utilizing the cancer specificity of the PEG10 promoter to drive the expression of reporter genes. Plasmid insertion of a PEG10 promoter sequence optimized for enhanced output upstream of a reporter gene allowed detection of prostate cancer by near-infrared and positron emission tomography imaging after systemic administration of the plasmid in vivo. PEG10 expressing subcutaneous xenograft and intratibial tumor models were imaged by both modalities using this molecular genetic imaging strategy. This study demonstrates a preclinical proof-of-concept that the PEG10 promoter is a powerful and specific tool that can be utilized for noninvasive detection of aggressive prostate cancer subtypes.

Significance:
PEG10 is expressed by prostate cancer with constitutively active AR-splice variants that can be exploited for noninvasive molecular imaging of this aggressive prostate cancer subytpe.
Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial
Authors: Di Giacomo Anna Maria , Covre Alessia , Finotello Francesca , Rieder Dietmar , Danielli Riccardo , Sigalotti Luca , Giannarelli Diana , Petitprez Florent , Lacroix Laetitia , Valente Monica , Cutaia Ornella , Fazio Carolina , Amato Giovanni , Lazzeri Andrea , Monterisi Santa , Miracco Clelia , Coral Sandra , Anichini Andrea , Bock Christoph , Nemc Amelie , Oganesian Aram , Lowder James , Azab Mohammad , Fridman Wolf H. , Sautès-Fridman Catherine , Trajanoski Zlatko , Maio Michele 
Published: September 2019

Abstract

Purpose:
The immunomodulatory activity of DNA hypomethylating agents (DHAs) suggests they may improve the effectiveness of cancer immunotherapies. The phase Ib NIBIT-M4 trial tested this hypothesis using the next-generation DHA guadecitabine combined with ipilimumab.

Patients and Methods:
Patients with unresectable stage III/IV melanoma received escalating doses of guadecitabine 30, 45, or 60 mg/m2/day subcutaneously on days 1 to 5 every 3 weeks, and ipilimumab 3 mg/kg intravenously on day 1 every 3 weeks, starting 1 week after guadecitabine, for four cycles. Primary endpoints were safety, tolerability, and MTD of treatment; secondary were immune-related (ir) disease control rate (DCR) and objective response rate (ORR); and exploratory were changes in methylome, transcriptome, and immune contextures in sequential tumor biopsies, and pharmacokinetics.

Results:
Nineteen patients were treated; 84% had grade 3/4 adverse events, and neither dose-limiting toxicities per protocol nor overlapping toxicities were observed. Ir-DCR and ir-ORR were 42% and 26%, respectively. Median CpG site methylation of tumor samples (n = 8) at week 4 (74.5%) and week 12 (75.5%) was significantly (P &lt; 0.05) lower than at baseline (80.3%), with a median of 2,454 (week 4) and 4,131 (week 12) differentially expressed genes. Among the 136 pathways significantly (P &lt; 0.05; Z score &gt;2 or ←2) modulated by treatment, the most frequently activated were immune-related. Tumor immune contexture analysis (n = 11) demonstrated upregulation of HLA class I on melanoma cells, an increase in CD8+, PD-1+ T cells and in CD20+ B cells in posttreatment tumor cores.

Conclusions:
Treatment of guadecitabine combined with ipilimumab is safe and tolerable in advanced melanoma and has promising immunomodulatory and antitumor activity.
Outcome-Related Differences in Gene Expression Profiles of High-Grade Serous Ovarian Cancers Following Neoadjuvant Chemotherapy
Authors: Octeau David , Kessous Roy , Klein Kathleen , Kogan Liron , Pelmus Manuella , Ferenczy Alex , Greenwood Celia M.T. , Van Kempen Leon C. , Salvador Shannon , Lau Susie , Tonin Patricia N. , Yasmeen Amber , Gotlieb Walter H. 
Published: September 2019

Abstract

Large-scale genomic studies have detailed the molecular landscape of tumors from patients with high-grade serous ovarian cancers (HGSC) who underwent primary debulking surgery and correlated the identified subgroups to survival. In recent years, there is increased use of neoadjuvant chemotherapy (NACT) for patients with HGSC and while abundant data exist for patients who underwent primary debulking, little data are available on the cancer cells remaining after NACT that could lead to recurrences. We aimed to analyze gene expression profiles of NACT-treated HGSC tumor samples, and correlate them to treatment response and outcome. Tumor samples were collected from patients with stage III or IV HGSC (NACT cohort, N = 57) at the time of surgery and diagnosis (biopsy samples N = 8). Tumor content was validated by histologic examination and bioinformatics. Gene expression analysis was performed using a tailored NanoString-based assay, while sequencing was performed using MiSeq. A cross-validated survival classifier revealed patient clusters with either a “Better” or “Worse” prognostic outcome. The association with overall survival remained significant after controlling for clinical variables, and differential gene expression, gene set enrichment analyses, and the appropriate survival models were used to assess the associations between alterations in gene expression in cancer cells remaining after NACT and outcome. Pathway-based analysis of the differentially expressed genes revealed comparatively high levels of cell cycle and DNA repair gene expression in the poor outcome group.

Implications:
Our work suggests mRNA expression patterns in key genes following NACT may reflect response to treatment and outcome in patient with HGSC.
‘Wishing You a Speedy Termination of Existence’
Authors: Djurdjevic Gordan 
Published: September 2019

Abstract
Aleister Crowley was considerably influenced by the doctrines of Theravāda Buddhism, which he studied in his youth, both theoretically and practically. He correlated its principles to the principles of scientific agnosticism and considered that its objectives could also be achieved through the practice of ceremonial magic. His eventual acceptance of Thelema’s religious philosophy led to his ultimate renunciation of Buddhism as a worldview. This essay examines Crowley’s early writings on the subject of Buddhism and suggests that the presence of Buddhist theories remains quite significant in his formulation of the doctrine of Thelema.
Guillaume Postel’s ‘Idea of the Zohar’
Authors: Weiss Judith 
Published: September 2019

Abstract
Following Boaz Huss’s coinage of an ‘Idea of the Zohar’, I focus in this paper on the ‘Idea of the Zohar’ held by the Kabbalistic Christian Guillaume Postel (1510–1581). Postel regarded the Zohar as an ultimate expression of his entire theological and messianic thought, and therefore he produced two Latin annotated translations of this treatise. Relying on a close analysis of the Incipit he attached to the earlier translation completed in early 1554 (BL ms. Slaone 1410, fol. 1r), I sketch Postel’s unique concepts regarding the Zohar, both as a text and as a divine essence, showing how his description of the Zohar’s provenance and circulation sheds light on his particular ‘Idea of the Zohar’.
The Question of Divorce and the Mandate of the Jurist Over the Unwilling Husband in Lebanese Muslim Shiʿi Jurisprudence: A Legal Reform?
Authors: Berry Moulouk 
Published: September 2019

AbstractThis article examines Muḥammad Mahdī Shams al-Dīn’s unstudied work, Fasād al-ʿalāqa al-zawjiyya: Wilāyat al-ḥākim al-sharʿī. Shams al-Dīn, who at the time was the head of the Supreme Islamic Shiʿi Council (SISC) and oversaw the religious courts in Lebanon dealing with personal status laws (marriage, divorce, child custody, inheritance laws), witnessed at firsthand women’s suffering, loss of rights, and the long court battles when a husband refused to divorce. The injustices committed against women by some men prompted Shams al-Dīn to find a juristic basis for curtailing men’s power and for defending women’s rights to custody, maintenance, and the deferred bridal gift. In the aforementioned work, Shams al-Dīn examines the scope and limits of the jurist’s authority, and whether such authority allows the jurist to execute divorce without the husband’s approval. His understanding of the concept of the jurist’s authority over the unwilling husband, coupled with his theoretical considerations on marital relations, has wider implications for Lebanese Shiʿi Muslim women and Jaʿfarī religious courts in Lebanon. Despite the profound nature of his reforms, Shams al-Dīn’s work is problematic, in that he leaves the husband’s unilateral right to divorce (even if provisionally) untouched and falls short of finding the theoretical basis for a contract in which equality between the spouses is built-in (even though it is possible in Shiʿi law).
Impact of Tropical Cyclone Initialization on Its Convection Development and Intensity: A Case Study of Typhoon Megi (2010)
Authors: Chang Yi-Pin , Yang Shu-Chih , Lin Kuan-Jen , Lien Guo-Yuan , Wu Chien-Ming 
Published: September 2019

AbstractThis study investigates the impact of tropical cyclone (TC) initialization methods on TC intensity prediction under a framework coupling the Weather Research and Forecasting Model with the TC Centered-Local Ensemble Transform Kalman Filter (WRF TCC-LETKF). While the TC environments are constrained by assimilating the same environmental observations, two different initialization strategies, assimilating real dropsonde observations (the DP experiment) and synthetic axisymmetric surface wind structure (the VT experiment), are employed to construct the TC inner-core structure. These two experiments have distinct results on predicting the rapid intensification (RI) of Typhoon Megi (2010), which can be attributed to their different convective burst (CB) development. In DP, the assimilation of the dropsondes helps establish a realistic TC structure with asymmetry information, leading to scattered CB distribution and persistent RI with abundant moisture supply. In VT, assimilating the axisymmetric surface wind structure spins up the TC efficiently. However, the initially excessive CB coverage causes a too-early high-level warm core, and the reduced moisture supply hinders RI. The forecast results imply that if the TC structure is initialized using a scheme considering only the axisymmetric vortex structure, the RI potential can possibly be underestimated due to the inability to represent the realistic asymmetric structure. Finally, assimilation of both the real and synthetic data can be complementary, giving a strong TC initially that undergoes a longer RI period.
Developing an Automated Medium-Range Flood Awareness System for Switzerland Based on Probabilistic Forecasts of Integrated Water Vapor Fluxes
Authors: Mahlstein Irina , Bhend Jonas , Spirig Christoph , Martius Olivia 
Published: September 2019

Abstract
Floods in the Alpine region can be destructive and cause large economic losses. Many rivers and lakes in Switzerland are regulated and flood damage can be mitigated through an optimal management of lake levels and runoff. This requires high-quality forecasts of atmospheric flood precursors extending beyond short-range (forecast days 1–5) predictions. In several places around the world atmospheric rivers or extreme integrated vapor transport (IVT) are causally related to flood events. Also in Switzerland, extreme IVT oriented perpendicular to the main orography heralds extreme flood events. This relationship is exploited in an operational flood warning system on the medium-range (here forecast days 6–10) time scale based on probabilistic medium-range forecasts of IVT and precipitation over Switzerland provided by the European Centre for Medium-Range Weather Forecasts (ECMWF) Integrated Forecasting System (IFS). This entails first a comprehensive probabilistic verification of the direction and magnitude of (extreme) IVT and second the development of compact visualizations for the operational use by hydrologists. Based on 20 years of probabilistic reforecasts, we show that both regular and extreme IVT has a better predictability than precipitation and IVT is predictable out to day 8. As the direction of IVT is of central importance for flood risk in Switzerland, we develop a visualization that summarizes probabilistic information on both the direction and magnitude of the IVT together with users of the product. The result is an operational flood warning system based solely on atmospheric flood precursors to extend flood warning information beyond the range of high-resolution deterministic weather forecasts.