bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey of green manure productivity on dryland organic grain farms in the eastern prairie region of Canada
Authors: Thiessen Martens Joanne R. , Lynch Derek H. , Entz Martin H. 
Published: June 2019

Little is known about legume green manure productivity on organic farms. Soil and plant tissue were sampled in annual, biennial, and perennial green manures on 41 fields in the eastern prairies. Green manure biomass averaged 4572 kg ha−1; 53% was legume plant material and 18% was weeds. Soil test P and plant tissue P concentrations were below critical levels in about half of all green manures. Mean N fixation was estimated at 71 kg ha−1. This observational study provides a baseline for future research to optimize green manure and nutrient management in organic grain production systems.
Neutron diffraction study of the crystal structure of TlInSe2 at high pressure
Authors: Mamedov N. T. , Jabarov S. H. , Kozlenko D. P. , Ismayilova N. A. , Seyidov M. Yu. , Mammadov T. G. , Dang N. T. 
Published: June 2019

We have investigated the crystal structure of strongly anisotropic semiconductor TlInSe2 by neutron diffraction method under high pressure upto P = 3.3 GPa. It was shown that the tetragonal phase of TlInSe2 crystal (the space group I4/mcm) is stable in the whole investigated range of pressure. The lattice parameters dependence of the pressure and the unit cell volume are obtained, the linear coefficients of compressibility and the bulk moduli are calculated. At the low pressure, obtained value of compressibility for the lattice parameter a is k[Formula: see text] = 14.23 × 10[Formula: see text] GPa[Formula: see text] and for c is k[Formula: see text] = 5.93 × 10[Formula: see text] GPa[Formula: see text]. Obtained values for bulk modulus B0 and its pressure derivative B[Formula: see text] in tetragonal phase are 30(7) GPa and 4(1), respectively.
The piezoresistive properties research of SiC thin films prepared by RF magnetron sputtering
Authors: Wu Jing , Zhao Xiaofeng , Ai Chunpeng , Yu Zhipeng , Wen Dianzhong 
Published: June 2019

To research the piezoresistive properties of SiC thin films, a testing structure consisting of a cantilever beam, SiC thin films piezoresistors and a Cr/Pt electrode is proposed in this paper. The chips of testing structure were fabricated by micro-electro-mechanical system (MEMS) technology on a silicon wafer with [Formula: see text]100[Formula: see text] orientation, in which SiC thin films were deposited by using radio-frequency (13.56 MHz) magnetron sputtering method. The effect of sputtering power, annealing temperature and time on the microstructure and morphology of the SiC thin films were investigated by the X-ray diffraction (XRD) and scanning electron microscopy (SEM). It indicates that a good continuity and uniform particles on the SiC thin film surface can be achieved at sputtering power of 160 W after annealing. To verify the existence of Si–C bonds in the thin films, X-ray photoelectron spectroscopy (XPS) was used. Meanwhile, the piezoresistive properties of SiC thin films piezoresistors were measured using the proposed cantilever beam. The test result shows that it is possible to achieve a gauge factor of 35.1.
THE INTERACTION OF INTUITION AND RATIONALITY DURING ESCALATED NPD DECISIONS: AN INVESTIGATION OF DECISION-MAKERS’ AFFECTIVE STATES
Authors: ROETH TOBIAS , SPIETH PATRICK , JOACHIM VERENA 
Published: June 2019

Decision-makers often struggle to terminate unsuccessful new product development (NPD) projects, so that escalating commitment occurs. Although research shows that rational and intuitive decision-making styles (DMS) as well as a decision-maker’s affective state determines the performance of NPD decisions, little is known about their influences on escalating commitment. By applying the affect infusion model in an experimental study, we investigate how a decision-maker’s affective state influence their escalating commitment by focusing on their use of a rational and an intuitive DMS. Our findings, based on 366 respondents, show that a rational DMS is unable to reduce commitment escalation. Surprisingly, an intuitive DMS is able to reduce a decision-maker’s commitment in the case of a positive affect, whereas a rational DMS increases their commitment in the case of a negative affect. Thus, our interdisciplinary research on affect and decision-making extends and contributes to research into decision-making during the NPD process as well as into escalating commitment.
Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1
Authors: Zhang Leilei , Zhang Jie , Ye Zhiwei , Manevich Yefim , Ball Lauren E. , Bethard Jennifer R. , Jiang Yu-Lin , Broome Ann-Marie , Dalton Annamarie C. , Wang Gavin Y. , Townsend Danyelle M. , Tew Kenneth D. 
Published: June 2019

Abstract

ME-344 is a second-generation isoflavone with unusual cytotoxic properties that is in clinical testing in cancer. To identify targets that contribute to its anticancer activity and therapeutic index, we used lung cancer cell lines that are naturally sensitive or resistant to ME-344. Drug-induced apoptosis was linked with enhanced levels of reactive oxygen species and this initiated a nuclear erythroid factor 2-like 2 signaling response, downstream of which, heme oxygenase 1 (HO-1) was also found to be time-dependently inhibited by ME-344. ME-344 specifically bound to, and altered, HO-1 structure and increased HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells. These effects did not occur in either drug-resistant or primary lung fibroblasts with lower HO-1 basal levels. HO-1 was confirmed as a drug target by using surface plasmon resonance technology and through interaction with a clickable ME-344 compound (M2F) and subsequent proteomic analyses, showing direct binding of ME-344 with HO-1. Proteomic analysis showed that clusters of mitochondrial proteins, including voltage-dependent anion-selective channels, were also impacted by ME-344. Human lung cancer biopsies expressed higher levels of Nrf2 and HO-1 compared with normal tissues. Overall, our data show that ME-344 inhibits HO-1 and impacts its mitochondrial translocation. Other mitochondrial proteins are also affected, resulting in interference in tumor cell redox homeostasis and mitochondrial function. These factors contribute to a beneficial therapeutic index and support continued clinical development of ME-344.

Significance:
A novel cytotoxic isoflavone is shown to inhibit heme oxygenase, a desirable yet elusive target that disrupts redox homeostasis causing cell death.
A Private Secretary from Golden Gate: Lin Shumei in Jinmen (Quemoy), Taiwan and Xiamen
Authors: Chan Ying-kit 
Published: June 2019

Abstract
The exponential growth of the population from the founding decades of the Qing Dynasty to the early nineteenth century placed tremendous stress on the local bureaucracies, which increasingly depended on county clerks and runners and the nondegree-holding literati to reduce costs within the Qing Empire. This article investigates the life of Lin Shumei 林樹梅 (1808–1851), a private secretary, or muyou 幕友, from Jinmen who had served in semiofficial capacities in Taiwan and Xiamen, highlighting the kind of opportunities that were available to him in the imperial bureaucracy. By plotting the career trajectory of Lin Shumei, the article shows that the defence, governance and settlement of the frontier regions of the Qing Empire depended more on the expertise of ‘men on the spot’ such as Lin than on policies devised in the imperial and provincial capitals.
Rapid Cyclogenesis from a Mesoscale Frontal Wave on an Atmospheric River: Impacts on Forecast Skill and Predictability during Atmospheric River Landfall
Authors: Martin Andrew C. , Ralph F. Martin , Wilson Anna , DeHaan Laurel , Kawzenuk Brian 
Published: June 2019

Abstract
Mesoscale frontal waves have the potential to modify the hydrometeorological impacts of atmospheric rivers (ARs). The small scale and rapid growth of these waves pose significant forecast challenges. We examined a frontal wave that developed a secondary cyclone during the landfall of an extreme AR in Northern California. We document rapid changes in significant storm features including integrated vapor transport and precipitation and connect these to high forecast uncertainty at 1–4-days’ lead time. We also analyze the skill of the Global Ensemble Forecast System in predicting secondary cyclogenesis and relate secondary cyclogenesis prediction skill to forecasts of AR intensity, AR duration, and upslope water vapor flux in the orographic controlling layer. Leveraging a measure of reference accuracy designed for cyclogenesis, we found forecasts were only able to skillfully predict secondary cyclogenesis for lead times less than 36 h. Forecast skill in predicting the large-scale pressure pattern and integrated vapor transport was lost by 96-h lead time. For lead times longer than 36 h, the failure to predict secondary cyclogenesis led to significant uncertainty in forecast AR intensity and to long bias in AR forecast duration. Failure to forecast a warm front associated with the secondary cyclone at lead times less than 36 h caused large overprediction of upslope water vapor flux, an important indicator of orographic precipitation forcing. This study highlights the need to identify offshore mesoscale frontal waves in real time and to characterize the forecast uncertainty inherent in these events when creating hydrometeorological forecasts.
Future research demands of the United European Gastroenterology (UEG) and its member societies
Authors: Enck Paul , Meisner Søren , Figueiredo Ceu , Mayerle Julia , Ricciardiello Luigi ,   the UEG Research Committee
Published: June 2019

AimsThe purpose of this study was to initiate and stimulate collaborative research efforts to support United European Gastroenterology Federation (UEG) member societies facilitating digestive health research in European on the one hand and, on the other hand, to increase EU‐funded digestive health research by providing evidence and advice to funding bodies on priority areas. The UEG Research Committee initiated a survey of the current and future research interests of each individual UEG ordinary member society (specialist societies).MethodsA questionnaire was sent by mail to 17 UEG ordinary member societies asking them to specify research demands related to the most urgent medical need including basic science research, translational research, clinical research, patient management research and research on disease prevention, in an open fashion but with limited word count.ResultsThe responses from 13 societies were analysed in a semi‐quantitative and in a qualitative way, and were clustered into five domains with two aspects each that were consented and shared between three and seven of the responding 13 societies. These clusters resemble topics such as ‘Hot topics’ (e.g. life‐style, nutrition, microbial‐host interaction), Biomarkers (genetic profiling, gut‐brain interaction), Advanced technology (artificial intelligence, personalised medicine), Global research tools (bio‐banking, EU trials), and Medical training (education, prevention).ConclusionThe generated topic list allows both collaboration between individual specialist societies as well as initiating and fostering future research calls at the EU level and beyond when approaching stakeholders.
Safety of vedolizumab in liver transplant recipients: A systematic review
Authors: Spadaccini Marco , Aghemo Alessio , Caprioli Flavio , Lleo Ana , Invernizzi Federica , Danese Silvio , Donato Maria F 
Published: June 2019

BackgroundThe management of inflammatory bowel disease in patients who have previously undergone liver transplantation can be a clinical challenge. There are serious concerns among physicians regarding the use of biologics for treating such immuno‐compromised patients.ObjectiveWe performed a systematic review on vedolizumab therapy in transplant recipients to assess its safety.MethodsPubMed/Embase/Scopus were searched up to November 2018 to identify papers regarding liver transplant recipients and therapy with vedolizumab. Primary outcomes were adverse events. Secondary outcomes were liver transplant and inflammatory bowel disease outcomes.ResultsEight studies (31 patients) were included. Nine out of 31 patients experienced an infection within a mean follow‐up time ranging from 5–20 months. No malignancies were reported. Inflammatory bowel disease clinical response was experienced by 20/26 patients. Abnormalities in liver tests were recorded in 2/22 patients.ConclusionVedolizumab may be considered safe for treating inflammatory bowel disease in liver transplant recipients. Caution is recommended for patients with an unstable liver graft function.
Early‐onset versus late‐onset Crohn’s disease: An Italian cohort study
Authors: Cantoro Laura , Lenti Marco Vincenzo , Monterubbianesi Rita , Cicala Michele , Giannarelli Diana , Papi Claudio , Kohn Anna , Di Sabatino Antonio 
Published: June 2019

BackgroundDisease heterogeneity, according to the age at onset, has been reported in Crohn’s disease (CD).ObjectiveThis study aimed to compare natural history in CD patients diagnosed ≤17 (early onset (EO)) versus ≥60 (late onset (LO)) years old.MethodsEO CD and LO CD patients referred to two Italian inflammatory bowel disease (IBD) centres were included. Relevant data comprised sex, current smoking, disease location and behaviour, IBD family history, extra‐intestinal manifestations and use of medical/surgical therapy during the follow‐up period.ResultsAmong 2321 CD patients, 160 met the inclusion criteria: 92 in the EO and 68 in the LO group (mean follow‐up 11.7 ± 7.7 years). Family history of IBD was more frequent in EO compared to LO CD (26% vs. 4%; p  < 0.0001). Ileocolonic, upper gastrointestinal and perianal involvement occurred more frequently in EO compared to LO CD (56% vs. 21%, p  < 0.0001; 17% vs. 3%, p  < 0.01; and 38% vs. 19%, p  < 0.01, respectively). Progression to complicated disease occurred more frequently in EO CD (40% vs. 10% p  < 0.005), with an increased use of corticosteroids and anti‐tumour necrosis factor alpha agents within 10 years since diagnosis (81% vs. 58%, p  = 0.004, and 36% vs. 16%, p  = 0.01, respectively), while the cumulative probability of surgery did not differ between the two groups.ConclusionsPatients with EO CD are more likely to develop a more aggressive disease with perianal involvement and a greater use of drug treatment compared to those with LO CD, without carrying an increased need for surgery.
Identification of five hub genes as monitoring biomarkers
for breast cancer metastasis in silico
Authors: Cai Yun , Mei Jie , Xiao Zhuang , Xu Bujie , Jiang Xiaozheng , Zhang Yongjie , Zhu Yichao 
Published: June 2019

Abstract
Background
Breast cancer is one of the most common endocrine cancers among
females worldwide. Distant metastasis of breast cancer is causing an increasing
number of breast cancer-related deaths. However, the potential mechanisms of
metastasis and candidate biomarkers remain to be further explored.

Results
The gene expression profiles of GSE102484 were downloaded from the
Gene Expression Omnibus (GEO) database. Weighted gene co-expression network
analysis (WGCNA) was used to screen for the most potent gene modules associated
with the metastatic risk of breast cancer, and a total of 12 modules were
identified based on the analysis. In the most significant module
(R2 = 0.68), 21 network hub genes (MM > 0.90) were
retained for further analyses. Next, protein-protein interaction (PPI) networks
were used to further explore the biomarkers with the most interactions in gene
modules. According to the PPI networks, five hub genes (TPX2, KIF2C, CDCA8, BUB1B, and CCNA2) were identified as key genes associated with breast cancer
progression. Furthermore, the prognostic value and differential expression of
these genes were validated based on data from The Cancer Genome Atlas (TCGA) and
Kaplan-Meier (KM) Plotter. Receiver operating characteristic (ROC) curve analysis
revealed that the mRNA expression levels of these five hub genes showed excellent
diagnostic value for breast cancer and adjacent tissues. Moreover, these five hub
genes were significantly associated with worse distant metastasis-free survival
(DMFS) in the patient cohort based on KM Plotter.

Conclusion
Five hub genes (TPX2, KIF2C, CDCA8,
BUB1B, and CCNA2) associated with the risk of distant metastasis were extracted
for further research, which might be used as biomarkers to predict distant
metastasis of breast cancer.
The psychosis risk timeline: can we improve our preventive strategies? Part 3: primary common pathways and preventive strategies
Authors: Romain Karen , Eriksson Alexandra , Onyon Richard , Kumar Manoj 
Published: June 2019

SUMMARYPsychosis is a recognised feature of several psychiatric disorders and it causes patients significant distress and morbidity. It is therefore important to keep knowledge of possible risk factors for psychosis up to date and to have an overview model on which further learning can be structured. This article concludes a three-part series. It gives a review of evidence regarding common pathways by which many risk factors come together to influence the development of psychosis and finalises our suggested overview model, a psychosis risk timeline. The three primary pathways considered are based on the major themes identified in this narrative review of recent literature and they focus on neurological, neurochemical and inflammatory changes. We link each back to the factors discussed in the first and second parts of this series that alter psychosis risk through different mechanisms and at different stages throughout life. We then consider and summarise key aspects of this complex topic with the aim of providing current and future clinicians with a model on which to build their knowledge and begin to access and understand current psychosis research and implications for future preventive work.LEARNING OBJECTIVESAfter reading this article you will be able to:
•give an overview of common pathways thought to link identified risk factors with psychosis development•understand neurochemical, neurostructural and inflammatory changes associated with psychosis•demonstrate increased knowledge of possible preventive strategies.DECLARATION OF INTERESTNone.
Stereotactic body radio therapy for inoperable large hepatocellular cancers: results from a clinical audit
Authors: Chopra Supriya , George Karishma , Engineer Reena , Rajamanickam Karthick , Nojin Siji , Joshi Kishore , Swamidas Jamema , Shetty Nitin , Patkar Shraddha , Patil Prachi , Ostwal Vikas , Mehta Shaesta , Goel Mahesh 
Published: June 2019

Objectives:
To evaluate the outcomes of stereotactic radiotherapy (SBRT) in the treatment of inoperable hepatocellular carcinomas (HCC) that are unsuitable for, or refractory to other liver-directed therapies.

Methods:
Between March 2015 and June 2018, patients with primary HCCs refractory to or unsuitable for treatment with other liver-directed therapies were treated with SBRT. Patients of Child status A5-B7 and with normal liver reserve ≥ 700 cc were preferred. Local control (LC), overall survival (OS), progression free survival (PFS) and effect of prognostic factors were analysed.

Results:
21 patients with inoperable HCCs were treated. The median tumour diameter was 9.6 cm (5-21) and median tumour volume was 350 cc (32.9 – 2541). The median SBRT dose prescription was 42 Gy/6 fractions (25 – 54 Gy/6#). The 1- and 2-year LC rate was 88 and 43 % respectively. Overall rate of &gt; grade III toxicity was 14 %. Patients with Child A5 liver function had a better median OS than A6 and B7 patients [21 vs 11 vs 8 months]. Also, tumours with GTV &lt; 350 cc volumes had a better OS compared to GTV of greater than 350 cc [24 months vs 8 months, p value = 0.004].

Conclusions:
This study showed that SBRT can be used safely and effectively to treat inoperable HCCs with or without prior loco-regional therapies, resulting in good local control and survival with acceptable toxicity.

Advances in knowledge:
Use of SBRT in inoperable HCC is safe and effective.
An investigation of the prevalence of compassion fatigue, compassion satisfaction and burnout in those working in animal-related occupations using the Professional Quality of Life (ProQoL) Scale
Authors: Scotney Rebekah L , McLaughlin Deidre , Keates Helen L 
Published: June 2019

Background: Animal-related occupational stress and compassion fatigue are important issues as they can have a negative impact on employee mental wellbeing, workplace productivity and morale. The impacts of these conditions are notable and have become more recognised by those who are employed in animal-related occupations. Aims: This study aims to investigate the incidence of compassion satisfaction and compassion fatigue (burnout and secondary traumatic stress) in those working in animal-related occupations using the Professional Quality of Life (ProQoL) Scale. Methods: Data were collected from 229 employees from a range of animal-related occupations using an anonymous self-report survey. Results: Most respondents were employed in veterinary practice (either veterinarians or veterinary nurses/technicians) and 85% of all respondents were female. 42% of participants were between 26 and 35 years of age and, 71% had been working in animal-related occupations between 1 and 10 years. Most participants scored in the mean or top quartile on the compassion satisfaction scale; however, about a quarter reported a score which indicated that they were deriving less satisfaction from their work. Low burnout was reported by 78% of participants; however, 21% of participants had a score which indicated that they were at higher risk of burnout. Low or average symptoms of secondary traumatic stress was reported by 74% of participants; however, 25.8% were at risk of secondary traumatic stress. While most of the surveyed population scored in the mean or top quartile on the compassion satisfaction scale, all of the occupational categories reported experiencing the negative aspects of caring: burnout and secondary traumatic stress. Conclusion: The prevalence of compassion fatigue demonstrated in these results should be a major concern in animal-related occupations and thus, be used as a beneficial, contextualised resource to inform resilience training programmes and preventative strategies specifically targeted towards those working in animal-related occupations.
599. Patrimonialización por desposesión. Resistencia y cambio social en procesos de patrimonialización de territorios urbanos del sur de Chile: Biobío, Araucanía y Los Ríos
Authors: Guerrero Valdebenito Rosa Maria 
Published: June 2019

Desde una perspectiva crítica los procesos de construcción patrimonial son acciones que han estado históricamente ligadas a las luchas por el poder social, lo cual ha dado forma a diversos conflictos, éstos han quedado relegados del discurso patrimonial autorizado, dando forma a lo que entendemos como patrimonios subalternos. El artículo analiza las tensiones y conflictos entre ambos discursos a partir del análisis de los procesos de patrimonialización local en Chile, particularmente de una tendencia central de éstos: los procesos de patrimonialización como resistencia y cambio social. A partir de lo anterior el artículo busca aportar elementos críticos a la comprensión del fenómeno patrimonial los cuales se han visto solapados por un discurso patrimonial hegemónico fuertemente esencialista.