bluuebunny/crossref_metadata_2025_split huggingface dataset:
The well-posedness of solution to a compressible non-Newtonian fluid with self-gravitational potential
Authors: Song Yukun , Chen Shuai , Liu Fengming 
Published: January 2019

AbstractWe study the initial boundary value problem of a compressible non-Newtonian fluid. The system describes the motion of the compressible viscous isentropic gas flow driven by the non-Newtonian self-gravitational force. The existence of strong solutions are derived in one dimensional bounded intervals by constructing a semi-discrete Galerkin scheme. Moreover, the uniqueness of solutions are also investigated. The main point of the study is that the viscosity term and potential term are fully nonlinear, and the initial vacuum is allowed.
Effects of Postactivation Potentiation After an Eccentric Overload Bout on Countermovement Jump and Lower-Limb Muscle Strength
Authors: Beato Marco , Stiff Adam , Coratella Giuseppe 
Published: January 2019

Abstract
Beato, M, Stiff, A, and Coratella, G. Effects of postactivation potentiation after an eccentric overload bout on countermovement jump and lower-limb muscle strength. J Strength Cond Res 35(7): 1825–1832, 2021—This study aimed to evaluate the postactivation potentiation (PAP) effects of an eccentric overload (EOL) exercise on countermovement jump (CMJ) performance and isokinetic lower-limb muscle strength. Eighteen active men (mean ± SD, age 20.2 ± 1.4 years, body mass 71.6 ± 8 kg, and height 178 ± 7 cm) were involved in a randomized, crossover study. The subjects performed 3 sets per 6 repetitions of EOL half squats at maximal power using a flywheel ergometer. Postactivation potentiation using an EOL exercise was compared with a control condition (10-minute cycling at 1 W·kg−1). Countermovement jump height, peak power, impulse, and force were recorded at 15 seconds, 1, 3, 5, 7, and 9 minutes after an EOL exercise or control. Furthermore, quadriceps and hamstrings isokinetic strength were performed. Postactivation potentiation vs. control reported a meaningful difference for CMJ height after 3 minutes (effect size [ES] = 0.68, p = 0.002), 5 minutes (ES = 0.58, p = 0.008), 7 minutes (ES = 0.57, p = 0.022), and 9 minutes (ES = 0.61, p = 0.002), peak power after 1 minute (ES = 0.22, p = 0.040), 3 minutes (ES = 0.44, p = 0.009), 5 minutes (ES = 0.40, p = 0.002), 7 minutes (ES = 0.29, p = 0.011), and 9 minutes (ES = 0.30, p = 0.008), as well as quadriceps concentric, hamstrings concentric, and hamstrings eccentric peak torque (ES = 0.13, p = 0.001, ES = 0.24, p = 0.003, and ES = 0.22, p = 003, respectively) after 3–9 minutes of rest. In conclusion, the present outcomes highlight that PAP using an EOL bout improves height, peak power, impulse, and peak force during CMJ, as well as quadriceps and hamstrings isokinetic strength in male athletes. Moreover, the optimal time window for the PAP was found from 3 to 9 minutes.
Development of Crack Arrest Temperature Test Method by Using a Local Temperature Gradient
Authors: An Gyubaek , Bae Hong-Yeol , Park Jeong-Ung 
Published: January 2019

Abstract
This study evaluated the brittle Crack Arrest Temperature (CAT) through an isothermal crack arrest test. Generally, the embrittled zone is required in a CAT test. According to conventional studies, the test method consists of arresting a double tension–type brittle crack with an Electron Beam melt-run, which acts as a crack initiator and crack runway. However, conventional CAT test methods have disadvantages in that they need additional processes to create an embrittled zone with Electron Beam Welding (EBW). A Local Temperature Gradient (LTG) system is developed to overcome the limitations of the conventional EBW embrittlement CAT test method. LTG systems do not require additional EBW to develop a brittle zone to initiate a brittle crack. In a LTG system, the LTG method is proposed instead of EBW to create the embrittled zone. The LTG system is free of flaws. In EBW, it is impossible to perform accurate CAT tests because the presence of defects affects the brittle crack arrest. In this study, a new CAT test method is introduced to evaluate brittle CATs more easily. Furthermore, both test methods were compared for the same specimens to verify the validity of the test method.
Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury
Authors: Chao Honglu , Lin Chao , Zuo Qiang , Liu Yinlong , Xiao Mengqing , Xu Xiupeng , Li Zheng , Bao Zhongyuan , Chen Huimei , You Yongping , Kochanek Patrick M. , Yin Huiyong , Liu Ning , Kagan Valerian E. , Bayır Hülya , Ji Jing 
Published: January 2019

Mitochondrial energy production is essential for normal brain function. Traumatic brain injury (TBI) increases brain energy demands, results in the activation of mitochondrial respiration, associated with enhanced generation of reactive oxygen species. This chain of events triggers neuronal apoptosis via oxidation of a mitochondria-specific phospholipid, cardiolipin (CL). One pathway through which cells can avoid apoptosis is via elimination of damaged mitochondria by mitophagy. Previously, we showed that externalization of CL to the mitochondrial surface acts as an elimination signal in cells. Whether CL-mediated mitophagy occursin vivoor its significance in the disease processes are not known. In this study, we showed that TBI leads to increased mitophagy in the human brain, which was also detected using TBI models in male rats. Knockdown of CL synthase, responsible forde novosynthesis of CL, or phospholipid scramblase-3, responsible for CL translocation to the outer mitochondrial membrane, significantly decreased TBI-induced mitophagy. Inhibition of mitochondrial clearance by 3-methyladenine, mdivi-1, or phospholipid scramblase-3 knockdown after TBI led to a worse outcome, suggesting that mitophagy is beneficial. Together, our findings indicate that TBI-induced mitophagy is an endogenous neuroprotective process that is directed by CL, which marks damaged mitochondria for elimination, thereby limiting neuronal death and behavioral deficits.SIGNIFICANCE STATEMENTTraumatic brain injury (TBI) increases energy demands leading to activation of mitochondrial respiration associated with enhanced generation of reactive oxygen species and resultant damage to mitochondria. We demonstrate that the complete elimination of irreparably damaged organelles via mitophagy is activated as an early response to TBI. This response includes translocation of mitochondria phospholipid cardiolipin from the inner membrane to the outer membrane where externalized cardiolipin mediates targeted protein light chain 3-mediated autophagy of damaged mitochondria. Our data on targeting phospholipid scramblase and cardiolipin synthase in genetically manipulated cells and animals strongly support the essential role of cardiolipin externalization mechanisms in the endogenous reparative plasticity of injured brain cells. Furthermore, successful execution and completion of mitophagy is beneficial in the context of preservation of cognitive functions after TBI.
Loci Contributing to Boric Acid Toxicity in Two Reference Populations ofDrosophila melanogaster
Authors: Najarro Michael A , Hackett Jennifer L , Macdonald Stuart J 
Published: January 2019

AbstractPopulations maintain considerable segregating variation in the response to toxic, xenobiotic compounds. To identify variants associated with resistance to boric acid, a commonly-used household insecticide with a poorly understood mechanism of action, we assayed thousands of individuals from hundreds of strains. Using the Drosophila Synthetic Population Resource (DSPR), a multi-parental population (MPP) of inbred genotypes, we mapped six QTL to short genomic regions containing few protein-coding genes (3–188), allowing us to identify plausible candidate genes underlying resistance to boric acid toxicity. One interval contains multiple genes from the cytochrome P450 family, and we show that ubiquitous RNAi of one of these genes, Cyp9b2, markedly reduces resistance to the toxin. Resistance to boric acid is positively correlated with caffeine resistance. The two phenotypes additionally share a pair of QTL, potentially suggesting a degree of pleiotropy in the genetic control of resistance to these two distinct xenobiotics. Finally, we screened the Drosophila Genetic Reference Panel (DGRP) in an attempt to identify sequence variants within mapped QTL that are associated with boric acid resistance. The approach was largely unsuccessful, with only one QTL showing any associations at QTL-specific 20% False Discovery Rate (FDR) thresholds. Nonetheless, these associations point to a potential candidate gene that can be targeted in future validation efforts. Although the mapping data resulting from the two reference populations do not clearly overlap, our work provides a starting point for further genetic dissection of the processes underlying boric acid toxicity in insects.
Inbred Strain Variant Database (ISVdb): A Repository for Probabilistically Informed Sequence Differences Among the Collaborative Cross Strains and Their Founders
Authors: Oreper Daniel , Cai Yanwei , Tarantino Lisa M , de Villena Fernando Pardo-Manuel , Valdar William 
Published: January 2019

Abstract
The Collaborative Cross (CC) is a panel of recently established multiparental recombinant inbred mouse strains. For the CC, as for any multiparental population (MPP), effective experimental design and analysis benefit from detailed knowledge of the genetic differences between strains. Such differences can be directly determined by sequencing, but until now whole-genome sequencing was not publicly available for individual CC strains. An alternative and complementary approach is to infer genetic differences by combining two pieces of information: probabilistic estimates of the CC haplotype mosaic from a custom genotyping array, and probabilistic variant calls from sequencing of the CC founders. The computation for this inference, especially when performed genome-wide, can be intricate and time-consuming, requiring the researcher to generate nontrivial and potentially error-prone scripts. To provide standardized, easy-to-access CC sequence information, we have developed the Inbred Strain Variant Database (ISVdb). The ISVdb provides, for all the exonic variants from the Sanger Institute mouse sequencing dataset, direct sequence information for CC founders and, critically, the imputed sequence information for CC strains. Notably, the ISVdb also: (1) provides predicted variant consequence metadata; (2) allows rapid simulation of F1 populations; and (3) preserves imputation uncertainty, which will allow imputed data to be refined in the future as additional sequencing and genotyping data are collected. The ISVdb information is housed in an SQL database and is easily accessible through a custom online interface (http://isvdb.unc.edu), reducing the analytic burden on any researcher using the CC.
Going Viral: News Sharing and Shared News in Social Media
Authors: Wadbring Ingela , Ödmark Sara 
Published: January 2019

Through the advent of social media, news achieves a life of its own online. The media organisations partly lose control over the diffusion process, and simultaneously individuals gain power over the process, and become opinion leaders for others. This study focusses on news sharers and news shared (or rather, interacted), and has three RQ:s: 1) What characterises the people who share news in social media, 2) Have the characteristics of interacted news changed over time? and 3) Are there differences between news content interacted by ordinary people and news highlighted by media organisations? Two different studies have been conducted: A representative survey and a quantitative content analysis.
The main results are that the opinion leaders differ from the majority by being younger, with a greater political interest, single and more digital in their general lifestyle, both concerning news consumption and other aspects. The content analysis shows that the most interacted news on social media follow the traditional news values rather well, with a few exceptions. Most apparent is that interacted news is more positive over time and compared to print front-page news. Accidents and crime dominate print front-pages, while politics is more prominent in interacted news.
Fair Allocation of Indivisible Goods to Asymmetric Agents
Authors: Farhadi Alireza , Ghodsi Mohammad , Hajiaghayi Mohammad Taghi , Lahaie Sébastien , Pennock David , Seddighin Masoud , Seddighin Saeed , Yami Hadi 
Published: January 2019

We study fair allocation of indivisible goods to agents with unequal entitlements. Fair allocation has been the subject of many studies in both divisible and indivisible settings. Our emphasis is on the case where the goods are indivisible and agents have unequal entitlements. This problem is a generalization of the work by Procaccia and Wang (2014) wherein the agents are assumed to be symmetric with respect to their entitlements. Although Procaccia and Wang show an almost fair (constant approximation) allocation exists in their setting, our main result is in sharp contrast to their observation. We show that, in some cases with n agents, no allocation can guarantee better than 1/n approximation of a fair allocation when the entitlements are not necessarily equal. Furthermore, we devise a simple algorithm that ensures a 1/n approximation guarantee.
Our second result is for a restricted version of the problem where the valuation of every agent for each good is bounded by the total value he wishes to receive in a fair allocation. Although this assumption might seem without loss of generality, we show it enables us to find a 1/2 approximation fair allocation via a greedy algorithm. Finally, we run some experiments on real-world data and show that, in practice, a fair allocation is likely to exist. We also support our experiments by showing positive results for two stochastic variants of the problem, namely stochastic agents and stochastic items.
Using of Monofocal Intraocular Lenses Different Types for Cataract Surgery in Adult Patients: Systematic Review
Authors: Krysanov I. S. , Krysanova V. S. , Ermakova V. Yu. 
Published: January 2019

Objectives: to perfom analysis of the clinical efficacy and safety of using monofocal IOLs in the surgical treatment of cataracts in adult patients. Material and methods. In available sources (databases of the Cochrane Library and Medline) a search was conducted to evaluate the effectiveness and safety of using monofocal IOLs in cataract surgery in adult patients according to the PICO(S) regimen. A literature review was conducted in July 2018 for the keywords “intraocular lenses” and “cataract” using the following filters: clinical trial, randomized clinical trial, meta-analysis, systematic review (clinical trial, randomized clinical trial, meta-analysis, systematic review). Posting languages: English. Depth of search — 5 years. Last search date is July 27, 2018. Results. An initial search in the Medline database found 21,737 publications and 2157 in the Cochrane Library database. A total of 17,894 links were found. In a meta-analysis Zhao Y. et al., 2017, a comparison of the incidence of opacities of the posterior capsule (secondary cataract) after surgical treatment with the implantation of hydrophobic and hydrophilic IOLs was made. In multicenter retrospective cohort study Ursell P., et al, 2018 assessed the frequency of the Nd: YAG-laser capsulotomy for the treatment of secondary cataract which developed after the implantation of the IOL within the first 3 years after surgery. Conclusion. During the systematic review, the relationship between the incidence of complications (secondary cataracts) and the properties of the IOL material was found. The implantation of lenses from a hydrophobic material is associated with a lower incidence of secondary cataracts than the implantation of lenses from a hydrophilic material.
Dyslipidemia in psoriasis patients: a case-control study
Authors: Gupta Surinder , Garg Preeti , Gupta Nakul 
Published: January 2019

<p class="abstract"><strong>Background:</strong> Psoriasis is a chronic inflammatory disorder with defective proliferation and differentiation of keratinocytes. It is associated with metabolic syndrome i.e. dyslipidemia, hypertension, obesity, cardiovascular diseases and insulin resistance. The high incidence of cardiovascular events in psoriasis is highly associated with abnormal lipid metabolism. This case-control study was done in North Indian medical institute to investigate the levels of serum lipids in psoriasis patients taking in account various parameters like weight, height, body mass index, blood pressure and diabetes.</p><p class="abstract"><strong>Methods:</strong> We assessed the fasting lipid profile in 48 psoriasis patients and 48 healthy, age and sex matched controls.<strong></strong></p><p class="abstract"><strong>Results:</strong> The study found significant elevation (p&lt;0.05) of serum total cholesterol, triglycerides, low density lipoproteins (LDL) and very low density lipoproteins (VLDL) in psoriasis patients compared to controls. The levels of high density lipoproteins (HDL) were also significantly lower (p&lt;0.05) in psoriasis patients.</p><p class="abstract"><strong>Conclusions:</strong> This study suggests that psoriasis is a high risk disorder for cardiovascular mortality and morbidity because of its association with dyslipidemia.</p><p> </p>
Investigating the Mechanical Behavior of Reclaimed Asphalt Pavement (RAP) Bases in Large Scale Test Box
Authors: SEFEROĞLU Ayşegül Güneş , SEFEROĞLU Mehmet Tevfik , AKPINAR Muhammet Vefa 
Published: January 2019

The objective of this research is to assess the elastic deformations and permanent strains of reclaimed asphalt pavement (RAP) material as a base layer when it is treated or untreated with puzzolanic cement under cyclic loads. A large-scale cyclic plate loading testing (CPLT) device was developed for studying the mechanical characteristics of pavement base layer materials. When the RAP percentage of the mixtures increased, elastic deformations and permanent strains increased, but the opposite is true when the cement percentage increased. It was concluded that 100% RAP material can be used in base layers with 3% cement. The obtained deformation values and strain rates can be used as reasonable default design input values to be used by pavement designers when using RAP as a substitute for natural aggregate base layers.
Futures Study in Health: A Review Study
Authors: Pouragha Behrooz , Baghian Najmeh , Najafi Marziye 
Published: January 2019

Background: Future is being continuously created at any moment and never stops. By reviewing the future, it can be discovered, evaluated and assessed to create desirable future. The health sector is daily faced with a variety of threats at different environmental, social, cultural, economic and political scales. To deal efficiently with these threats, it is necessary to use the future as an opportunity to promote people's health by investigating, anticipating and building it, and managing it properly. Therefore, this review was conducted with the aim of determining the domains and methods of future studies in the health sector.
Methods: In this review article, searching was performed by terms futures study or forecasting or fore sighting and health sector in four databases consisting of Two Persian databases Magiran and the Scientific Information Database and Two English ones Google Scholar and PubMed. In the first search, 531 articles were selected and retrieved. After the titles and abstracts were read and duplicate articles were excluded, and then the full texts of the remaining articles were reviewed, seven articles were included in the final analysis.
Results: The results of studies in the health sector show that future studies is an important tool and evidence for policy makers in almost all areas of the health system's functions, such as determining the amount and types of services needed, training specialists and other health sector’s staff, allocating funds, the number of beds and other facilities, developing and constructing of hospital wards, etc.
Conclusion: The results of studies in the health sector indicate that futures study provide important tools and evidence for policymakers in almost all areas of the health system's functions, such as determining the amount and types of services needed, allocating funds, number of beds, expansion of hospital departments, technology requirements, the impact of policies and programs.

Keyword: Futures Study, Foresight, forecasting, Health
The use of the interference microscopy to study structural characteristics of cultured dermal fibroblasts
Authors: Nefedova I. F. , Rossinskaya V. V. 
Published: January 2019

Rationale: The use of electron, nuclear power and confocal microscopy for the screening of biologically active compounds, medical products and express diagnostics of some diseases at the cell level is associated with laborand time-consuming sample preparation, which cannot exclude potential measurement errors and artifacts. The modulation interference microscopy does not have these disadvantages; it allows for non-invasive studies of cell structures, imaging with nanometer resolution and analysis of the optical properties of an object.Aim: To assess the potential of the interference microscopy in the evaluation of morphofunctional characteristics of in vitro mitomycin conditioned cultured cell nuclei (dermal fbroblasts taken as a model).Materials and methods: Native culture of human dermal fbroblasts of the 6th passage, grown on glass with mirror coating in the cell culture laboratory of the Institute of Experimental Medicine and Biotechnology of Samara State Medical University (Russia), was examined with a modulation interference microscope MIM-340 (JSC PA UOMZ, Russia). Changes over time in the structural characteristics of dermal fbroblast nuclei conditioned with mitomycin were evaluated. The control group included fbroblasts cultured in the same conditions on glass with mirror coating without mitomycin. Imaging with MIM-340 was done at three hours, one and four days after adding the cytostatic. The control group was assessed at the same time points.Results: We have shown that the cell culture grown on dielectric glasses does not diﬀer in its morphofunctional characteristics from the culture grown on culture plastics. This proves the possibility to study the adhesive native culture using interference microscopy. We have found that the cells respond to a single mitomycin 0.04% exposure with a change to a globular shape and a sharp increase in the nuclear phase thickness (217.8 vs. 142.18 nm in the control group, p ≤ 0.05). Thereafter, the morphofunctional characteristics of the cells are restored, which is confrmed by the changes over time in the culture density, cell shape and size, and the phase thickness of the nucleus.Conclusion: The results obtained make it possible to recommend the method of modulation interference microscopy for evaluation of toxicity and biocompatibility of drugs, medical products and physical factors for diagnosis and treatment.