bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep quality in children with hepatic glycogen storage diseases, a prospective observational pilot study
Authors: Agnoletto Lucas , Vandeleur Moya , White Mary , Adams Anne‐Marie , Halligan Rebecca , Peters Heidi 
Published: December 2024

AbstractBackgroundHepatic glycogen storage diseases (GSDs) are characterised by enzyme defects affecting liver glycogen metabolism, where carbohydrate supplementation to prevent overnight hypoglycaemia is common. Concerns around sleep quality in hepatic GSDs relate to emerging evidence that overnight dysglycaemia impacts sleep quality.MethodsThis prospective observational study reported sleep quality and duration in children with hepatic GSDs over 7 days utilising: actigraphy (Actiwatch 2 by Phillips Respironics), sleep diaries, proxy reported age‐appropriate sleep and quality‐of‐life (QoL) questionnaires, in the context of nocturnal glycaemic profiles continuous glucose monitor (CGM, Dexcom G6) and nocturnal dietary management strategies. Significant hypo‐ and hyperglycaemia were defined as ≥1% of sleep diary documented nocturnal period, recording <3.5 and >10.0 mmol/L, respectively.ResultsSeven children with hepatic GSD (aged 1–17 years) participated. Objective sleep quality was poor, with actigraphy demonstrating that no child achieved the minimum sleep duration recommended for age. Subjective sleep quality was also poor, with 4/5 documenting significant daytime sleepiness and 6/6 reporting poor sleep hygiene. Children prescribed overnight bolus feeds (OBF) (n = 2) recorded shorter sleep duration compared to other nocturnal management strategies. Parent‐reported QoL suggested poor disease‐related QoL outcomes for this cohort.ConclusionObjective and subjective sleep disturbances and reduced QoL are common within our sample of children with hepatic GSD. From our observations these outcomes may be linked to nutritional overnight interventions, especially OBFs, rather than overnight glucose levels. Consideration of the impacts of overnight feeding strategies on sleep quality and QoL in children with hepatic GSD should inform future management strategies.
Performance Evaluation of Molecular Detection of Enteroviruses: Results of 18 Years of Quality Control for Molecular Diagnostics (QCMD) External Quality Assessment Program, 2005−2022
Authors: Benschop Kimberley S. M. , Staines Harry , Mckloud Emily , McCulloch Elaine , Montgomery Dorothy , Sutton Greg , Mantke O. Donoso , van Loon Anton 
Published: December 2024

ABSTRACTThe gold standard for enterovirus (EV) detection is the polymerase chain reaction based on the detection of the 5' untranslated region of the virus. Correct detection of EV is crucial for patient and public health purposes. The performance of diagnostic and public health laboratories on molecular EV‐detection was analyzed using data from the external quality assessment program distributed by Quality Control for Molecular Diagnostics (QCMD) between 2005 and 2022. Overall performance on core samples of both laboratory types has improved over the years for in‐house or commercial assays (overall performance rate > 94.8%) since 2013. A similar improvement was observed for negative/specificity samples. Performance on EV‐positive samples varied, with the lowest performance observed on samples containing enterovirus D68 (B3 strain) and echovirus 11. Significant differences in performance were observed between laboratory and assay types. Performance of diagnostic laboratories (91.8) was significantly higher than of public health laboratories (89.9%; p < 0.0001). Additionally, a significant higher performance of diagnostic laboratories using commercial assays was observed (92.5% vs. 91.2% for in‐house assays; p < 0.0001). In contrast, the performance of public health laboratories using in‐house assays (90.1%) was higher than commercial assays (89.2%; p = 0.3608). The data document the improved performance of diagnostic and public health laboratories using either commercial or in‐house assays.
Multi‐Organ Spread and Intra‐Host Diversity of SARS‐CoV‐2 Support Viral Persistence, Adaptation, and a Mechanism That Increases Evolvability
Authors: Manrique Julieta M. , Maffia‐Bizzozero Santiago , Delpino M. Victoria , Quarleri Jorge , Jones Leandro R. 
Published: December 2024

ABSTRACTIntra‐host diversity is an intricate phenomenon related to immune evasion, antiviral resistance, and evolutionary leaps along transmission chains. SARS‐CoV‐2 intra‐host variation has been well‐evidenced from respiratory samples. However, data on systemic dissemination and diversification are relatively scarce and come from immunologically impaired patients. Here, the presence and variability of SARS‐CoV‐2 were assessed among 71 tissue samples obtained from multiple organs including lung, intestine, heart, kidney, and liver from 15 autopsies with positive swabs and no records of immunocompromise. The virus was detected in most organs in the majority of autopsies. All organs presented intra‐host single nucleotide variants (iSNVs) with low, moderate, and high abundances. The iSNV abundances observed within different organs indicate that the virus can mutate at one host site and subsequently spread to other parts of the body. In agreement with previous data from respiratory samples, our lung samples presented no more than 10 iSNVs each. But interestingly, when analyzing different organs we were able to detect between 11 and 45 iSNVs per case. Our results indicate that SARS‐CoV‐2 can replicate, and evolve in a compartmentalized manner, in different body sites, which agrees with the “viral reservoir” theory. We elaborate on how compartmentalized evolution in multiple organs may contribute to SARS‐CoV‐2 evolving so rapidly despite the virus having a proofreading mechanism.
Hepatic Flare Following Effective Antiretroviral Therapy Is Associated With HBsAg Seroclearance in HBV/HIV‐1 Co‐Infection
Authors: Lin Weiyin , He Yaozu , Gu Fei , Hu Fengyu , Yu Haisheng , Li Hong , Liu Cong , Tang Xiaoping , Cai Weiping , Li Linghua 
Published: December 2024

ABSTRACTLittle is known about the clinical significance of hepatic flare following effective antiretroviral therapy (ART) on HBsAg seroclearance and prognosis in HBV/HIV co‐infection. This observational cohort study recruited HBV/HIV‐1 co‐infected patients from the China National Free Antiretroviral Treatment Program. We obtained longitudinal information on demographic characteristics, clinical indicators, and treatment outcomes. Hepatic flare was defined as an elevation of ALT of more than five times the upper limit of the normal range without an upsurge of HBV DNA or HBsAg at any time point between ART initiation and 12 months. Among the 1354 enrolled patients, 98.7% received two anti‐HBV drugs containing ART and 95.1% achieved good viral control. Hepatic flare was observed in 88 (6.5%) patients and was more frequent in those with lower baseline immune function but subsequently enhanced immune reconstitution. Over a median follow‐up of 4.7 years, we observed 99 HBsAg seroclearance, 9 hepatic events, 6 HIV‐associated malignancy, 3 non‐HIV‐associated malignancy, and 3 all‐cause mortality. The 3‐, 5‐, and 10‐year cumulative incidence of HBsAg seroclearance was 6.4%, 8.9%, and 12.9%, respectively. Compared to patients without hepatic flare, patients with hepatic flare had significantly higher rates of HBsAg seroclearance (13.6% vs. 6.9%, p = 0.018) but had no recorded adverse outcome. Multivariate analysis with different models indicated that hepatic flare was independently associated with HBsAg seroclearance especially in patients with low immune function, normal ALT, and high levels of HBV DNA and HBsAg at baseline. In HBV/HIV‐1 co‐infection, hepatic flare following effective ART is associated with HBsAg seroclearance. HBV‐specific T cells immune reconstitution may represent a potential mechanism which deserves further investigation.
Preparation of composite film based on corn starch and soybean fiber composites blended in 1‐ethyl‐3‐methylimidazolium chloride
Authors: Zhao Zhe , Yang Rui , Chen Dan , Wan Jie , Huang Wenwen , Prakash Sangeeta 
Published: December 2024

AbstractBACKGROUNDTo overcome the deficiency of pure starch in film‐forming performance, ionic liquids (ILs) have been introduced when preparing a homogeneous blend of starch and fiber. It is essential to select the appropriate ratio of starch to fiber and evaluate the film‐forming property of the resulted composites. In the present study, 1‐ethyl‐3‐methylimidazolium chloride ([EMIM]Cl) was used to prepare composites of soybean fiber (SF) and corn starch (CS) at various ratios. The gelatinization properties, water holding capacity, expansibility and film‐forming properties of CS‐SF composites were measured.RESULTSThe results showed that the composites had good water holding capacity and expansibility. They easily dissolved in water to form a low‐viscosity solution, which contributed to improve their film‐forming performance. Furthermore, the addition of SF improved the mechanical and barrier properties of the film, and composites with higher SF content exhibited excellent film pliability that remained flexibility even after 30 days of storage.CONCLUSIONThe findings demonstrate that the ratio of corn starch to soybean fiber will affect the film‐forming properties of the composites formed in [EMIM]Cl. The CS‐SF composite film with a CS to SF ratio of 1:1 exhibited the best overall performance. The performance improvement of these CS‐SF composite films may be attributed to the molecular entanglement or intermolecular interaction between starch and fiber. These findings provide valuable information for the development of degradable starch‐fiber composite films. © 2024 Society of Chemical Industry.
Comprehensive Investigation of Sweroside Metabolism in Rats Using a De Novo Strategy Based on Ultra‐High‐Performance Liquid Chromatography/Quadrupole‐Exactive Mass Spectrometry
Authors: Sun Xuelin , Shang Zhanpeng , Zhang Yatong , Qiu Jiantao , Tan Xueying 
Published: December 2024

ABSTRACTSweroside, a natural secoiridoid glycoside derived from various medicinal plants, is known for its anti‐tumor, anti‐inflammatory, and hepatoprotective properties. However, its pharmacological significance is not fully supported by its low systemic exposure. In this study, a de novo strategy was proposed to investigate the metabolism of sweroside in rats, including drug administration, sample pretreatment, ultra‐high‐performance liquid chromatography/Quadrupole‐Exactive mass spectrometry data acquisition, data processing, and semi‐quantitative analysis. First, following oral administration of sweroside to rats, plasma, urine, and feces were collected, and respectively mixed using the area‐under‐the‐curve pooling method. Secondly, data‐dependent, dynamic exclusion, and parallel reaction monitoring scan modes were employed to build a tandem mass spectra database. Using a neutral loss fragment‐based method, target metabolites were effectively filtered. As a result, sweroside was demonstrated to be extensively metabolized, while 18 metabolites were identified and nine of them were newly reported. Sweroside predominantly underwent phase II metabolism, including glycosylation, sulfonation, glucuronidation, and deglycosylation, and were primarily excreted via the kidney. Notably, N‐heterocyclization (M7 and M10) was likely catalyzed by intestinal bacteria. This study not only elucidates the in vivo drug elimination of sweroside but also offers an efficient approach for profiling the metabolism of specific molecules.
On the size‐dependent vibrations of doubly curved porous shear deformable FGM microshells
Authors: Karami Behrouz , Ghayesh Mergen H. , Hussain Shahid , Amabili Marco 
Published: December 2024

AbstractThis paper aims to analyse the free vibrations of doubly curved imperfect shear deformable functionally graded material microshells using a five‐parameter shear deformable model. Porosity is modeled via the modified power‐law rule by a logarithmic‐uneven variation along the thickness. Coupled axial, transverse, and rotational motion equations for general doubly curved microsystems are obtained by a virtual work/energy of Hamilton's principle using a modified first‐order shear deformable theory including small size dependence. The modal decomposition method is then used to obtain a solution for different geometries of microshells: spherical, elliptical, hyperbolic, and cylindrical. A detailed study on the influence of material gradation and porosity, small‐length scale coefficient, and geometrical parameters on the frequency characteristics of the microsystem is conducted for different shell geometries.
Confidence Intervals for the Risk Difference Between Secondary and Primary Infection Based on the Method of Variance Estimates Recovery
Authors: Chen Chao , Li Yuanzhen , Wei Qitong , Huang Zhigang , Chen Yanting 
Published: December 2024

ABSTRACTThe risk difference (RD) between the secondary infection, given the primary infection, and the primary infection can be a useful measure of the change in the infection rates of the primary infection and the secondary infection. It plays an important role in pharmacology and epidemiology. The method of variance estimate recovery (MOVER) is used to construct confidence intervals (CIs) for the RD. Seven types of CIs for binomial proportion are introduced to obtain MOVER‐based CIs for the RD. The simulation studies show that the Agresti‐Coull CI, score method incorporating continuity correction CI, Clopper Pearson CI, and Bayesian credibility CI are conservative. The Jeffreys CI, Wilson score CI, and Arcsin CI draw a satisfactory performance; they are suitable for various practical application scenarios as they can provide accurate and reliable results. To illustrate that the recommended CIs are competitive or even better than other methods, three real datasets were used.
Neighborhood Face Index: A New Quantitative Structure Property Relationship (QSPR) Approach for Predicting Physical Properties of Polycyclic Chemical Compounds
Authors: Raza Ali , Rasheed Muhammad Waheed , Mahboob Abid , Ismaeel Mishal 
Published: December 2024

ABSTRACTTopological indices (TIs) are numerical parameters that characterize the biochemical and physio‐chemical properties of compounds. These graph‐based descriptors are valuable tools for predicting key attributes, such as melting points, boiling points, bond energies, and bond lengths, based on the molecular structures of the compounds. A variety of TIs have been developed, including the Randić index, Zagreb index, atom‐bond connectivity index, geometric index, and harmonic index. In this work, we introduce a new topological index called the neighborhood face index, which demonstrates a strong correlation with various physical properties such as bond energies and boiling points, achieving a correlation coefficient of . This indicates its robust predictive capability. Furthermore, the results are thoroughly analyzed using graphical tools to provide deeper insights.
Nonequilibrium Dynamics at Cellular Interfaces: Insights From Simulation and Theory
Authors: Jiao Zheng , Gao Lijuan , Jin Xueqing , Li Jiaqi , Wang Yuming , Chen Wenlong , Yan Li‐Tang 
Published: December 2024

ABSTRACTActive matters, which consume energy to exert mechanical forces, include molecular motors, synthetic nanomachines, actively propelled bacteria, and viruses. A series of unique phenomena emerge when active matters interact with cellular interfaces. Activity changes the mechanism of nanoparticle intracellular delivery, while active mechanical processes generated in the cytoskeleton play a major role in membrane protein distribution and transport. This review provides a comprehensive overview of the theoretical and simulation models used to study these nonequilibrium phenomena, offering insights into how activity enhances cellular uptake, influences membrane deformation, and governs surface transport dynamics. Furthermore, we explore the impact of membrane properties, such as fluidity and viscosity, on transport efficiency and discuss the slippage dynamics and active rotation behaviors on the membrane surface. The interplay of active particles and membranes highlights the essential role of nonequilibrium dynamics in cellular transport processes, with potential applications in drug delivery and nanotechnology. Finally, we provide an outlook highlighting the significance of deeper theoretical and simulation‐based investigations to optimize active particles and understand their behavior in complex biological environments.
Gravity Energy Storage: A Review on System Types, Techno‐Economic Assessment and Integration With Renewable Energy
Authors: Cai Kun , Han Yifeng , Xia Rui , Wu Jinming , Wang Jun , Lund Peter D. 
Published: December 2024

ABSTRACTGravity energy storage (GES) technology relies on the vertical movement of heavy objects in the gravity field to store or release potential energy which can be easily coupled to electricity conversion. GES can be matched with renewable energy such as photovoltaic and wind power. Considering the potential relevance of GES in the future power market, this review focuses on different types of GES, their techno‐economic assessment, and integration with renewable energy. The review shows that pumped hydro energy storage (PHES) has reached a high maturity level as a technical system and is well covered by economic evaluation methods, whereas solid gravity energy storage (SGES) is still in an initial stage for system design and assessment. Development and improvement of integration methods between various renewable energy sources and GES are key future development directions.
Fertilitätsprotektion bei benignen Erkrankungen
Authors: Böttcher Bettina 
Published: December 2024

Zusammenfassung
Zunehmend stellen auch benigne Erkrankungen mit erforderlicher gonadotoxischer oder operativer Therapie oder genetische Prädispositionen mit einem erhöhten Risiko für eine prämature Ovarialinsuffizienz Indikationen für fertilitätserhaltende Maßnahmen dar. Für diese Thematik sollte interdisziplinär zunehmend sensibilisiert werden, um diese Patientinnen frühzeitig zu identifizieren. Allerdings ist die Datenlage, beispielsweise zu Kosten-Nutzen-Analysen, Risiken und die spätere Inanspruchnahme, noch sehr limitiert. Über eine altersabhängig reduzierte ovarielle Reserve und eine nicht zu späte Familienplanung sollte generell im Sinne einer „fertility awareness“ informiert werden.
Resilienzförderung durch Musik und Kunst
Authors: Hennenberg Beate , Löffler-Stastka Henriette 
Published: December 2024

Zusammenfassung
Für die Krankheitsverarbeitung und Erhaltung der psychischen Gesundheit spielen das Zusammenwirken von Medizin, Krankheitswahrnehmung und Musik sowie die Musik im Krankenhaussetting eine Rolle. Die als musikpädagogisches Seminar der Universität für Musik und darstellende Kunst am Comprehensive Center for Pediatrics (CCP) an der Universitätsklinik für Kinder- und Jugendheilkunde (UKKJ) Wien veranstaltete Musikwerkstatt You Smile richtet sich an Kinder und Jugendliche, die aufgrund schwerer und schwerster Erkrankungen für längere Zeit im Krankenhaus betreut werden müssen. Dieses pädagogische Projekt zielt darauf ab, Kindern zu zweit oder in Kleingruppensettings nicht nur einen Zugang zur Musik zu bieten, sondern sie auch in ihren musikalischen und sozialen Kompetenzen zu stärken und ihnen in einer schwierigen Lebensphase emotionale Unterstützung zu geben. Die Instrumentalpädagogik konzentriert sich traditionell auf den Unterricht in formellen Bildungseinrichtungen, so auch in diesem neuen edukativen, kommunikativen musikpädagogischen Kontext im Krankenhaussetting.
Amalgamating Urban Scaling and Economic Complexity for New Metrics of Urban Fitness
Authors: Sahasranaman Anand , Jensen Henrik Jeldtoft 
Published: December 2024

Abstract
We propose a synthesis of the independent scientific frameworks of economic complexity and urban scaling into a consistent mechanism—city complexity—to measure multi-dimensional fitness of cities. Essentially, we use deviations from scaling law for a given set of urban outcomes as the basis to construct a bipartite city-outcome matrix. This matrix forms the input into the economic complexity methodology, which iterates over a pair of coupled non-linear maps, computing fitness of cities and complexity of outcomes. We test our algorithm with data from American cities and find that the emergent city fitness measure is consistent with expected behavior across the set of outcomes studied. We also find temporal evolution of city fitness and outcome complexity to be in agreement with theoretical expectation. Finally, we perturb the metrics to conditions of widespread socioeconomic stress and find that outcomes are indicative of the robustness of the city complexity algorithm. Overall, these findings suggest that the city complexity mechanism proposed here produces systematic, self-consistent metrics and can be applied across any set of diverse outcomes, irrespective of the specifics of national urban contexts.
Managerial identity work: a systematic literature review with a conceptual model
Authors: Westen Wiktoria , Graça Manuel 
Published: December 2024

AbstractThis article presents a systematic review of Managerial Identity Work (MIW) literature, the ongoing process through which managers shape, negotiate, and redefine their professional identities in response to organizational, societal, and personal pressures. By synthesizing 61 empirical studies based on the PRISMA methodology, eight central themes within MIW are identified: identity work of first-time managers, identity work of experienced managers, management development programs, external perceptions of identity, blurred identity, creation of preferred identity, identity work as a medium, and identity work of minorities. These themes are further integrated into aggregate dimensions—knowledge, awareness, motivation, and privilege—culminating in a conceptual model that elucidates the relationships between them. This study not only consolidates the extant literature but also provides a framework for understanding the key factors shaping managerial identity formation. By mapping the geographical and industrial contexts of MIW research, this review uncovers gaps in the literature and proposes directions for future inquiry, particularly regarding MIW’s implications for leadership development, organizational culture, and managerial legitimacy.