bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scoliosis vertebral growth plate histomorphometry: Comparisons to controls, growth rates, and compressive stresses
Authors: Bylski‐Austrow Donita I. , Glos David L. , Wall Eric J. , Crawford Alvin H. 
Published: September 2018

ABSTRACTScoliosis progression in skeletally immature patients depends on remaining growth. Relationships between vertebral growth plate histomorphometry, growth rates, and mechanical stresses have been reported in several animal studies. Hypertrophic zone heights and chondrocyte heights have been used to assess treatments that aim to modulate growth. The purpose of this study was to determine whether human vertebral physeal hypertrophic zone and cell heights differed between two groups: Severe scoliosis and autopsy controls. Severity was defined at time of surgical planning by curve magnitude and curve stiffness. Physeal samples were obtained from the convex side apex, and from the concave side when feasible. Histologic sections were prepared, and digital images were used to measure hypertrophic zone height, cell height, and cell width. Thirteen spinal deformity patients were included, mean curve magnitude 67° (±23). Etiologies were juvenile and adolescent idiopathic, congenital, neurofibromatosis, neuromuscular, and Marfan syndrome. Five age‐matched autopsy specimens without scoliosis served as controls. Results were presented by etiology, then all convex scoliosis specimens were combined and compared to controls. Zone heights for scoliosis, convex side, and controls were 152 µm (±34) and 180 µm (±42) (p = 0.21), cell heights 8.5 µm (±1.1) and 12.8 µm (±1.2) (p < 0.0005), and cell widths 14.9 µm (±1.5) and 15.0 µm (±2.5), respectively. Human values were compared to published animal models and to a quantitative theory of a stress ̶ growth curve. This quantification of vertebral physeal structures in scoliosis may be expected to help assess theories of progression and potential treatments using growth modulation. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2450–2459, 2018.
Comparative efficacy of agricultural by‐products in sequestering mycotoxins
Authors: Greco Donato , D'Ascanio Vito , Santovito Elisa , Logrieco Antonio F , Avantaggiato Giuseppina 
Published: September 2018

AbstractBACKGROUNDBiosorption using agricultural by‐products has been proven as a low‐cost and safe way to sequester mycotoxins. Few agricultural by‐products have been studied for their efficacy in adsorbing simultaneously a large range of mycotoxins. The present work compared the ability of 51 agricultural by‐products to adsorb mycotoxins from liquid mediums simulating physiological pH values, and it studied the mechanism for mycotoxin adsorption by isotherm adsorption experiments.RESULTSGrape pomaces, artichoke wastes, and almond hulls were selected as promising biosorbents for mycotoxins, being quite effective towards aflatoxin B1 (AFB1), zearalenone (ZEA), and ochratoxin A (OTA). Their adsorption was not affected by medium pH, and the adsorbed fraction was not released when pH rose from acid to neutral values. Fumonisin B1 (FB1) was adsorbed to a lesser extent, and deoxynivalenol adsorption was not recorded. For the selected biosorbents, maximum adsorption capacity calculated by the best fitting model (Freundlich, Langmuir, or Sips equation) ranged from 1.2 to 2.9 µg mg−1 for AFB1, 1.3 to 2.7 µg mg−1 for ZEA, 0.03 from 2.9 µg mg−1 for OTA, and 0.01–1.1 µg mg−1 for FB1.CONCLUSIONThis study confirms that some agricultural by‐products can find technological applications as feed/food additives for mycotoxin reduction. © 2018 Society of Chemical Industry
A comparative study of obstetric anal sphincter injuries in vaginal deliveries of twins and singleton pregnancies
Authors: Doumouchtsis Stergios K. , Fahmay Youstina , Sedgwick Philip , Durnea Constantin M. 
Published: September 2018

AimsIncreasing numbers of twin pregnancies necessitate investigation of the risk factors associated with obstetric anal sphincter injuries (OASIS). The aims of this study were to establish the incidence of OASIS, and compare women delivering twins to those delivering singletons in risk of OASIS plus maternal, neonatal, and obstetric outcomes.MethodsA retrospective cohort study was undertaken and included women delivering in a tertiary London maternity unit between 1999 and 2015; 51 957 eligible women with singleton and 261 with twin pregnancies were identified. Women delivering twins were compared to those delivering singletons in the occurrence of maternal, neonatal, and obstetric outcomes using unadjusted relative risks. A secondary analysis was performed, and conditional logistic regression used to derive an adjusted relative risk of OASIS. Women delivering singletons were matched to those delivering twins for age, parity, ethnicity, gestation, and mode of delivery in a ratio of 2:1.ResultsCompared to the singleton group, mothers delivering twins had significantly more instrumental deliveries (RR [95%CI] 1.92 [1.67‐2.27]; P < 0.0001), smaller fetuses (2754.1 vs 3383.8 g; P < 0.001), and were older (32.9 vs 31.0 years; P < 0.0001). The twin group was not significantly different to the singleton group in risk of OASIS (RR 0.61 [0.27‐1.33], P = 0.205). The conditional logistic regression demonstrated similar results for the risk of OASIS (adjusted RR = 0.58 [0.22‐1.47]; P = 0.253).ConclusionsWomen delivering twins vaginally were not at a significantly higher risk of sustaining OASIS compared to those delivering singletons.
Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity: LIFE‐Moms Prospective Meta‐Analysis
Authors: Peaceman Alan M. , Clifton Rebecca G. , Phelan Suzanne , Gallagher Dympna , Evans Mary , Redman Leanne M. , Knowler William C. , Joshipura Kaumudi , Haire‐Joshu Debra , Yanovski Susan Z. , Couch Kimberly A. , Drews Kimberly L. , Franks Paul W. , Klein Samuel , Martin Corby K. , Pi‐Sunyer Xavier , Thom Elizabeth A. , Van Horn Linda , Wing Rena R. , Cahill Alison G. ,   the LIFE‐Moms Research Group
Published: September 2018

AbstractObjectiveThis study aimed to evaluate the effects of varied lifestyle intervention programs designed to ameliorate excess gestational weight gain (GWG) in pregnant women with overweight or obesity compared with standard care, including effects on pregnancy outcomes.MethodsSeven clinical centers conducted separate randomized clinical trials to test different lifestyle intervention strategies to modify GWG in diverse populations. Eligibility criteria, specific outcome measures, and assessment procedures were standardized across trials. The results of the separate trials were combined using an individual‐participant data meta‐analysis.ResultsFor the 1,150 women randomized, the percent with excess GWG per week was significantly lower in the intervention group compared with the standard care group (61.8% vs. 75.0%; odds ratio [95% CI]: 0.52 [0.40 to 0.67]). Total GWG from enrollment to 36 weeks' gestation was also lower in the intervention group (8.1 ± 5.2 vs. 9.7 ± 5.4 kg; mean difference: −1.59 kg [95% CI:−2.18 to −0.99 kg]). The results from the individual trials were similar. The intervention and standard care groups did not differ in preeclampsia, gestational diabetes, cesarean delivery, or birth weight.ConclusionsBehavioral lifestyle interventions focusing primarily on diet and physical activity among women with overweight and obesity resulted in a significantly lower proportion of women with excess GWG. This modest beneficial effect was consistent across diverse intervention modalities in a large, racially and socioeconomically diverse US population of pregnant women.
Monosubstituted hydrazone β-cyclodextrin derivatives for pH-sensitive complex formation with aromatic drugs
Authors: Majdecki Maciej , Krzak Agata , Żelechowska Kamila , Swiech Olga 
Published: September 2018

AbstractA new and convenient synthetic pathway was developed to produce monosubstituted cyclodextrins with high yields. Each of the β-cyclodextrin derivatives described in this work has an aromatic substituent connected with cyclodextrin core by a pH-sensitive hydrazone linker and a carbon chain. Carbon chains differ in lengths having one or three carbon atoms. The correlation between water solubility and linker length was determined using UV–Vis spectroscopy, while the dependence of hydrazone bond hydrolysis on the electrolyte pH was confirmed by cyclic voltammetry. The pH-dependent complex-formation ability between the hydrazone derivative of cyclodextrin and anthracycline drug was examined by square wave voltammetry. The significantly big solubility and the appropriate pH, at which the hydrolysis of the hydrazone bond occurs, make the newly synthesized derivatives attractive for pharmaceutical and medical applications.
Inflammation as a central mechanism in Alzheimer's disease
Authors: Kinney Jefferson W. , Bemiller Shane M. , Murtishaw Andrew S. , Leisgang Amanda M. , Salazar Arnold M. , Lamb Bruce T. 
Published: September 2018

AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaques and neurofibrillary tangles. Over the last decade, the presence of a sustained immune response in the brain has emerged as a third core pathology in AD. The sustained activation of the brain's resident macrophages (microglia) and other immune cells has been demonstrated to exacerbate both amyloid and tau pathology and may serve as a link in the pathogenesis of the disorder. In the following review, we provide an overview of inflammation in AD and a detailed coverage of a number of microglia‐related signaling mechanisms that have been implicated in AD. Additional information on microglia signaling and a number of cytokines in AD are also reviewed. We also review the potential connection of risk factors for AD and how they may be related to inflammatory mechanisms.
Marxism and Buddhism: Not Such Strange Bedfellows
Authors: PRIEST GRAHAM 
Published: September 2018

AbstractBuddhism and Marxism may seem unlikely bedfellows, since they come from such different times and places, and appear to address such different concerns. But the two have at least this much in common: both say that life, as we find it, is unsatisfactory; both have a diagnosis of why this is; and both offer the hope of making it better. In this paper, I argue that aspects of each complement aspects of the other. In particular, Buddhism provides a stable ethical base that Marxism always lacked; and Marxism provides a sophisticated political philosophy, which Buddhism never had. I will explain those aspects of each of the two on which I wish to draw, and then explain how they are complementary.
Omissions as Events and Actions
Authors: SILVER KENNETH 
Published: September 2018

AbstractWe take ourselves to be able to omit to perform certain actions and to be at times responsible for these omissions. Moreover, omissions seem to have effects and to be manifestations of our agency. So, it is natural to think that omissions must be events. However, very few people writing on this topic have been willing to argue that omissions are events. Such a view is taken to face three significant challenges: (i) omissions are thought to be somehow problematically negative, (ii) it is unclear where the event of an omission would be located, and (iii) if we accept any omissions as events, it seems like there would be far too much causation involving them. In this paper, I develop a novel view of omissions as events and as actions that provides answers to these challenges.
Border closures and the externalization of immigration controls in the Mediterranean: a comparative analysis of Morocco and Turkey
Authors: Üstübici Ayşen , İçduygu Ahmet 
Published: September 2018

AbstractThis article traces the recent history of border closures in Turkey and Morocco and their impact on human mobility at the two ends of the Mediterranean. Border closures in the Mediterranean have produced new spaces where borders are often fenced, immigration securitized, and border crossings and those facilitating border crossings criminalized. Here, bordering practices are conceptualized as physical bordering practices, border controls, and legal measures. Turkey and Morocco constitute comparable cases for an analysis of border closures insofar as they utilize similar mechanisms of closure, despite having quite different outcomes in terms of numbers. The article’s findings are based on fieldwork conducted at both locations between 2012 and 2014, as well as on analysis of Frontex Risk Assessment Reports from 2010 to 2016. The first part of the article reflects on the concepts of border closure and securitization, together with their implications, and draws for its argument on critical security studies and critical border studies. The second part of the article is an overview of controls over mobility exercised in the Mediterranean from the 1990s onward. Then, in the third and fourth parts, we turn to the particular cases—respectively, Turkey and Morocco—in order to discuss their processes of border closure and the various implications thereof. Through analysis of the two country cases, we show that border closures are neither linear nor irreversible.
Beyond the visible policy agenda: problem definitions disappearing from the agenda as nondecisions
Authors: Shpaizman Ilana 
Published: September 2018

AbstractIn the agenda-setting process, prior to the decision-making process, there is a predecisional process whereby some issues are systematically blocked by powerful actors from being placed on the formal agenda. These issues are termed “nondecisions”. This article argues that the predecisional process exists not only at the issue level but also at the level of problem definitions. Because of the empirical challenge of studying problem definitions that are not on the formal agenda, the article suggests examining problem definitions that were on the formal agenda and then disappeared from it. Such problem definitions can be termed nondecisions when their disappearance is due to latent power mechanisms, such as anticipated reactions or information control. The article tests these arguments using two American policy cases: prescription drug prices and child care. In so doing, it sheds light on the predecisional process and expands our understanding of the politics of problem definitions.
Household debt and depressive symptoms among older adults in three continental European countries
Authors: Hiilamo Aapo , Grundy Emily 
Published: September 2018

AbstractIn this comparative study focusing on the population aged 50 and over in three European countries, we investigate the association between household debt and depressive symptoms, and possible country differences in this association, using data from Waves 1, 2, 4, 5 and 6 of the Surveys of Health, Ageing and Retirement in Europe (SHARE) for Belgium, France and Germany. Multi-level regression models with random intercepts for individuals were used to analyse the association between household debt status and number of depressive symptoms (EURO-D score). Country differences in the household debt–depression nexus were tested using country interaction models. After controlling for other measures of socio-economic position and physical health, low or substantial financial debt was associated with a higher number of depressive symptoms in all countries. Housing debt was strongly linked to depressive symptoms for women while the association was weaker for men. The only country difference was that for both sexes substantial financial debt (more than €5,000) was strongly associated with depressive symptoms in Belgium and Germany, but the association was weak or non-significant in France. Associations between financial debt and depression were also evident in analyses of within-individual changes in depressive symptoms for a longitudinal sub-group, and in analyses using a dichotomised, rather than a continuous, measure of depression. The findings indicate that measures of household indebtedness should be taken into consideration in investigations of social inequalities in depression and suggest a need for mental health services targeted at indebted older people.
Quantitative Prediction of Lower Order Faults Based on the Finite Element Method: A Case Study of the M35 Fault Block in the Western Hanliu Fault Zone in the Gaoyou Sag, East China
Authors: Liu Jingshou , Ding Wenlong , Dai Junsheng , Wu Zhonghu , Yang Haimeng 
Published: September 2018

AbstractLower order faults (LOFs) are characterized by small‐scale, strong concealment and difficult to identify in seismic data, which affects the accuracy of LOF interpretation. Due to the quality of the seismic data in the M35 fault block of the Gaoyou sag, Subei basin, the direction of the LOFs cannot be accurately identified, leading to the unclear relationship between the injection and production wells in the local oil fields and affecting the development of the remaining oil. In this paper, the formation mechanism of LOFs in the M35 fault block is determined from analysis of the fault activity and tectonic evolution, and a finite element geomechanical model is established to simulate the paleostress field during the formation of the LOFs. Based on the relationship between the areal density of LOFs and the stress parameters, the regions of LOF development are predicted by the minimum principal stress, the maximum and minimum principal stress difference (Δσ), normal stress (σn), and the strain energy density; the shear stresses are used to predict the dip direction of the LOFs. Through the coordinate system transformation of the principal stress directions, the strikes of the LOFs are quantitatively predicted. Finally, the reliability of the prediction results is verified by the latest structural map of the M35 fault block. The method proposed in this paper can be widely applied to the quantitative prediction of multiple parameters of LOFs in complex fault blocks.
Simulating Short‐Term Evolution of Slow Slip Influenced by Fault Heterogeneities and Tides
Authors: Peng Yajun , Rubin Allan M. 
Published: September 2018

AbstractIn this study, we analyze high‐resolution tremor catalogs from northern Cascadia, Guerrero, and northern Kii Peninsula. We find that tremor often occurs in short bursts that repeatedly occupy the same source area within a slow slip event. We hypothesize that these bursts are driven by loading from slow slip in areas surrounding the tremor zone. Adopting a rate‐and‐state friction law with a velocity‐weakening to velocity‐strengthening transition, we develop a finite fault model in which the size of the slow slip zone is larger than that of the tremor zone. Tidal forcing is added. Many asperities are randomly distributed within the tremor zone in order to generate burst‐like slip evolution while maintaining reasonable propagation speeds of the main slow slip front. We successfully reproduce the increasing recurrence intervals of the bursts as the main front moves across the tremor zone, as well as tidally modulated secondary fronts well behind the main front.
Fragmentation of the Adriatic Promontory: New Chronological Constraints From Neogene Shortening Rates Across the Southern Alps (NE Italy)
Authors: Moulin Adrien , Benedetti Lucilla 
Published: September 2018

AbstractThe eastern Southern Alps are located at the northern tip of the Adria microplate, which imposes 2.0–2.5 mm/year of N‐S‐convergence relative to stable Eurasia. We map surface evidence of recent folding/faulting in this area from a 5‐m Digital Elevation Model (DEM). In the eastern part of the belt, observations reveal a 30‐km‐wide zone of active folding composed of at least five growing anticlines. The most recent ones warped the postglacial alluvial surface by <10 m. Combining these findings with published geological and geophysical data allows us to infer that active thrusting occurs along a single deeply rooted thrust, which accommodates the indentation of the Adriatic crust. Resolving the observed pattern of uplift on the inferred fault geometry indicates that NNE‐SSW shortening across the eastern Southern Alps has occurred at a rate of about 1.5 mm/year over the postglacial period. On the other hand, a balanced cross section for the eastern Southern Alps at the scale of the upper crust constrains a minimum of 43 km of finite shortening over the last 14 Ma, yielding a shortening rate of about 3 mm/year, which is 2 times higher than the postglacial shortening rate. This decrease in the shortening rate is associated to the Pleistocene activation of new thrusts that is compatible with a change in the direction of compression. The inferred local change in the kinematics of thrusting during the Pleistocene is consistent with a change from Nubia‐imposed to Adria‐imposed convergence indicating that the fragmentation of the Adriatic promontory could have occurred 1–2 Ma ago.
Rotational Kinematics of Basement Antiformal Stacks: Paleomagnetic Study of the Western Nogueras Zone (Central Pyrenees)
Authors: Izquierdo‐Llavall Esther , Casas‐Sainz Antonio M. , Oliva‐Urcia Belén , Villalaín Juan J. , Pueyo Emilio , Scholger Robert 
Published: September 2018

AbstractThe structure of the Pyrenean Axial Zone laterally transitions from an imbricate thrust system to an antiformal stack displaying downward facing structures in its frontal part (the Nogueras zone). We carried out a paleomagnetic study through this structural transition to better constrain thrust kinematics and better define the factors controlling the occurrence of antiformal stacks. Triassic red beds unconformably overlying the Paleozoic basement were sampled across three main thrust sheets (the Nogueras zone, the Bielsa, and the Orri thrust sheets). From 31 new sites, two meaningful magnetizations were defined, both carried by hematite: (1) the primary magnetization, that unblocks at 660–685 °C and (2) an intermediate‐temperature, syn‐orogenic remagnetization. Paleomagnetic data indicate variable, clockwise vertical axis rotations, with mean, thrust‐scale values that range from 0 to +38°. They increase both from the base to the top of the stacked units and from west to east and display a thrust‐scale directional dispersion that is higher for the lower wavelength thrusts. Results evidence that increasing thrust displacements in the upper thrusts units are a key factor for the formation of antiformal stacks showing downward facing structures. Displacement gradients in the basement are transferred to cover units and can account for important rotations such as those registered by the Mesozoic‐Cenozoic units to the south of the study area.