bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building Usability Knowledge for Health Information Technology: A Usability-Oriented Analysis of Incident Reports
Authors: Marcilly Romaric , Schiro Jessica , Beuscart-Zéphir Marie Catherine , Magrabi Farah 
Published: June 2019

Background The contribution of usability flaws to patient safety issues is acknowledged but not well-investigated. Free-text descriptions of incident reports may provide useful data to identify the connection between health information technology (HIT) usability flaws and patient safety.
Objectives This article examines the feasibility of using incident reports about HIT to learn about the usability flaws that affect patient safety. We posed three questions: (1) To what extent can we gain knowledge about usability issues from incident reports? (2) What types of usability flaws, related usage problems, and negative outcomes are reported in incidents reports? (3) What are the reported usability issues that give rise to patient safety issues?
Methods A sample of 359 reports from the U.S. Food and Drug Administration Manufacturer and User Facility Device Experience database was examined. Descriptions of usability flaws, usage problems, and negative outcomes were extracted and categorized. A supplementary analysis was performed on the incidents which contained the full chain going from a usability flaw up to a patient safety issue to identify the usability issues that gave rise to patient safety incidents.
Results A total of 249 reports were included. We found that incident reports can provide knowledge about usability flaws, usage problems, and negative outcomes. Thirty-six incidents report how usability flaws affected patient safety (ranging from incidents without consequence, to death) involving electronic patient scales, imaging systems, and HIT for medication management. The most significant class of involved usability flaws is related to the reliability, the understandability, and the availability of the clinical information.
Conclusion Incidents reports involving HIT are an exploitable source of information to learn about usability flaws and their effects on patient safety. Results can be used to convince all stakeholders involved in the HIT system lifecycle that usability should be considered seriously to prevent patient safety incidents.
A Newborn with Severe Ventriculomegaly: Expanding the PPP2R1A Gene Mutation Phenotype
Authors: Wallace Alexandra , Caruso Paul , Karaa Amel 
Published: June 2019

AbstractProtein phosphatase 2A (PP2A) is a heterotrimeric protein serine/threonine phosphatase that regulates a diverse range of cellular activities. The PPP2R1A gene on chromosome 19 (19q13.41) encodes the α isoform of the scaffolding subunit of the PP2A holoenzyme, which functions to link the catalytic subunit to the regulatory subunit. Here we present a case of a newborn boy with a novel PPP2R1A gene mutation (c.548G>A; p.Arg183Gln) with severe lateral and third ventriculomegaly, hypoplastic corpus callosum, and pontocerebellar hypoplasia. To our knowledge, this is the sixth case reported in the literature, thus expanding the phenotype of this rare genetic condition.
Incidence and Predictive Factors for Additional Opioid Prescription after Endoscopic Skull Base Surgery
Authors: Shen Sarek A. , Jafari Aria , Qualliotine Jesse R. , DeConde Adam S. 
Published: June 2019

Introduction Postoperative pain management and opioid use following endoscopic skull base surgery (ESBS) is not well understood. A subset of patients requires additional opioid prescription (AOP) in the postoperative period. The objective of this study is to describe the incidence of AOP, as well as evaluate patient and surgical characteristics that may predict additional pain management requirements following ESBS.
Methods A retrospective review of cases undergoing ESBS between November 2016 and August 2018 was performed. We reviewed patients' sociodemographic and clinical data, and Controlled Substance Utilization Review and Evaluation System (CURES) records. Stepwise multivariable logistic regressions were performed to evaluate the factors associated with AOP within 60 days following surgery.
Results A total of 42 patients were identified. Indications for ESBS included intracranial mass (64.2%), sinonasal malignancy (23.8%), and skull base reconstruction (9.5%). AOP were recorded in nine patients (21.4%). There were no significant differences in operative factors, including approach, lesion location, or perioperative analgesia between the two cohorts. On multivariable logistic regression, we found that younger age (odds ratio [OR]: 0.891, 95% confidence interval [CI]: 0.79–1.00, p = 0.050), comorbid depression (OR: 86.48, 95% CI: 1.40–5,379.07, p = 0.034), and preoperative opioid use (OR: 104.45, 95% CI: 1.41–7,751.10, p = 0.034) were associated with additional prescriptions postoperatively.
Conclusion The requirement for extended postoperative opioid pain control is common after ESBS. Patient demographics including age and psychosocial factors, such as depression may predict the need for AOP after ESBS. These results suggest that patient-driven factors, rather than surgical characteristics, may determine the need for prolonged pain control requirements after ESBS.
Clinical Outcomes and Multidisciplinary Patterns of Failure for Olfactory Neuroblastoma: The Ohio State Experience
Authors: Wolfe Adam R. , Blakaj Dukagjin , London Nyall , Blakaj Adriana , Klamer Brett , Pan Jeff , Wakely Paul , Prevedello Luciano , Bonomi Marcelo , Bhatt Aashish , Raval Raju , Palmer Joshua , Prevedello Daniel , Gamez Mauricio , Carrau Ricardo 
Published: June 2019

Purpose Olfactory neuroblastoma (ONB) is a rare head and neck cancer believed to be originated from neural crest cells of the olfactory membrane located in the roof of the nasal fossa. This study evaluates clinical outcomes and failure patterns in ONB patients of those patients treated with surgical resection at a high-volume tertiary cancer center.
Methods and Materials Thirty-nine ONB patients who underwent surgical resection at our institution from 1996 to 2017 were retrospectively identified. Univariate, multivariate, and survival analysis were calculated using Cox regression analysis and Kaplan–Meier log-rank.
Results Median follow-up time was 59 months (range: 5.2–236 months). The median overall survival (OS) and disease-free survival (DFS) for the entire cohort were 15 and 7.6 years, respectively. The 5-year cumulative OS and DFS were 83 and 72%, respectively. The 5-year OS for low Hyams grade (LHG) versus high Hyams grade (HHG) was 95 versus 61% (p = 0.041). LHG was found in 66% of the early Kadish stage patients compared with 28% in the advanced Kadish stage patients (p = 0.057). On multivariate analysis, HHG and positive node status predicted for worse OS and only HHG predicted for worse DFS. Of note, five patients (all Kadish stage A) who received surgical resection alone had no observed deaths or recurrences with a median follow-up of 44 months (range: 5–235 months).
Conclusion In this retrospective cohort, patients with positive nodes or HHG have significantly worse clinical outcomes. Future studies should explore treatment intensification for HHG or positive nodes.
Cofilin drives rapid turnover and fluidization of entangled F-actin
Authors: McCall Patrick M. , MacKintosh Frederick C. , Kovar David R. , Gardel Margaret L. 
Published: June 2019

Significance
When an animal cell moves or divides, a disordered network of actin filaments (F-actin) builds mechanical scaffolds to drive cell-shape changes. Actin filaments are undergoing continual cycles of assembly and disassembly, known as turnover, but it is unknown how these dynamics impact the mechanical properties of actin-filament-based networks. Here, we show that actin-filament turnover dynamics contribute to mechanical stress relaxation. Additionally, we identify the factors necessary to generate a nonequilibrium steady state of dynamic actin filaments that provides a picture of their regulation in vivo.
The tilted helix model of dynamin oligomers
Authors: Kadosh Avihay , Colom Adai , Yellin Ben , Roux Aurélien , Shemesh Tom 
Published: June 2019

Significance
Hydrolysis of GTP leads to remodeling of dynamin helical collars and severing of the underlying membrane neck—a critical step in vesicle endocytosis. We use mathematical modeling to explore the mechanisms that regulate oligomer deformation. We find that orientation of dynamin’s pleckstrin homology domain relative to the membrane introduces tilt strain. Relaxation of this strain requires departure of the oligomer from its intrinsic helical shape. Nonuniform accumulation of strain along the length of the dynamin chain results in partial oligomer fragmentation. The results of our model are corroborated experimentally by atomic force microscopy measurements. Our analysis leads to a definition of the tilted helix: a surface curve that maintains a fixed angle between the curve normal and the surface normal.
PRCD is essential for high-fidelity photoreceptor disc formation
Authors: Spencer William J. , Ding Jin-Dong , Lewis Tylor R. , Yu Chen , Phan Sebastien , Pearring Jillian N. , Kim Keun-Young , Thor Andrea , Mathew Rose , Kalnitsky Joan , Hao Ying , Travis Amanda M. , Biswas Sondip K. , Lo Woo-Kuen , Besharse Joseph C. , Ellisman Mark H. , Saban Daniel R. , Burns Marie E. , Arshavsky Vadim Y. 
Published: June 2019

Significance
The function of progressive rod-cone degeneration (PRCD) protein has remained a mystery since its gene and associated mutation were discovered as one of the most common causes of retinal degeneration in dogs. Furthermore, numerous mutations in the protein have since been identified to cause retinal degeneration in human patients diagnosed with retinitis pigmentosa. Here, we generated a PRCD knockout mouse and found that PRCD functions at the site of photoreceptor disc morphogenesis where it is required to keep newly forming discs flat as they protrude from the plasma membrane. Without PRCD, the newly forming discs bulge and release extracellular vesicles, which accumulate in the extracellular space and ultimately lead to retinal pathology.
“Let me now answer, very directly, Marie’s question”
Authors: Bull Peter , Waddle Maurice 
Published: June 2019

AbstractPrime Minister’s Questions (PMQs) in the UK attracts much criticism for the adversarial and occasional aggressive language on display. During his successful campaign for the leadership of the Labour Party, Jeremy Corbyn called for a “new kind of politics” (ITV 2015). One feature of his “new” approach, apparent during his early sessions as Leader of the Opposition, was to include questions to Prime Minister David Cameron sourced from members of the public. Although, subsequently, these “public questions” became less frequent, they provided an opportunity to compare their interactional effects with standard “non-public questions”. Arguably, the aim of this salient feature of corbyn’s approach to questioning Cameron was to redress the moral order of PMQs. We test this proposal via two measures of the PM’s responses: reply rate and personalisation. Results showed that Corbyn’s public questions did not enhance Cameron’s reply rate. However, whereas Cameron used significantly more personal attacks than Corbyn in response to non-public questions, the level of such attacks by the PM for public questions was as low as Corbyn’s, with no significant difference between them. In this latter regard, such an approach showed the potential to mitigate the ritualistic and customary verbal aggression of PMQs.
Moral impoliteness
Authors: Parvaresh Vahid 
Published: June 2019

AbstractThis study is concerned with the increasing use of impolite language that one observes during interactions which take place over the Internet. Drawing on a number ofInstagramposts uploaded by various socialites and public figures, this study proposes the notion of a ‘Basic Moral Perspective’ as being a window to an understanding of the nature of some impolite language witnessed on social media. I define ‘Basic Moral Perspective’ as the moral predisposition which interactants possess. As the study shows, in contexts in which there appears to be little relational history between interactants, the ‘Basic Moral Perspective’, amongst other factors, that interactants bring to an interaction can potentially result in impolite language. As will be shown throughout the study, the interactants’ Basic Moral Perspective can provide a clue as to how certain interactions are responded to.
General converbs in Andi
Authors: Verhees Samira 
Published: June 2019

AbstractThis paper describes the semantic and morphosyntactic properties of general converb constructions in Andi, a language of the Avar-Andic group of the East Caucasian language family. There are two general converbs in Andi, both of which are homophonous with a finite verb form (the aorist and the perfect, respectively). There is a considerable functional overlap between the two converbs. Both can be used to render the first stage of a complex event. The perfect / converb can also specify manner. An additive particlelooften accompanies the perfect as converb, while a specialised particlelodːuappears with the aorist as converb. The situation in Andi is unusual, because the two converbs are functionally very similar and not opposed in terms of aspect. In addition, Andi seems to be the only East Caucasian language where a specialised particle (i.e.lodːu) is found in this type of converbal clauses.
Flat as a wall or flat as a butcher’s hand
Authors: Tartakovsky Roi , Shen Yeshayahu 
Published: June 2019

Abstract
Foregrounding theory deals with the relation between deviant textual device (e.g., alliteration) and the effect on
readers (e.g., high aesthetic evaluation). While previous research has tended to look at an array of devices together in longer
stretches of text, we focus on an isolated, semantic foregrounding device, the closed simile. We introduce a distinction between
the standard and non-standard simile, representing first- and second-order foregrounding, respectively, and test the idea that the
more deviant version would yield higher ratings in terms of the aesthetic, cognitive, and emotive dimensions of text appreciation.
Our first finding is that experts prefer the more foregrounded version whereas novices opt for the less foregrounded one. However,
our second finding is that, when the novices are prompted to interpret the similes prior to rating them, the non-standard version
yields higher ratings. We conclude by discussing some implications of the present research for foregrounding theory.
What if two involving stories contradict each other?
Authors: Komori Megumi 
Published: June 2019

Abstract
This study investigated the relationship between individual differences in narrative transportation and attitude
robustness. A total of 840 respondents participated in a web survey. In the first phase of the survey, respondents indicated their
attitudes toward social issues after reading supporting or opposing texts with narrative and persuasive messages. After two weeks,
the same participants read another text expressing the opposite perspective on the same issue, and again indicated their
attitudes. Attitude robustness (i.e., degree of change in attitude between phases) was significantly predicted by transportability
and mediated by transportation-related concepts of situational involvement. Additionally, whereas situational involvement with
narrative text was predicted by transportability, situational involvement with persuasive text was consistently predicted by
self-involvement with the issues. Implications of the findings for narrative transportation and persuasion research and
limitations of the study are discussed.
Cantharidin decreased viable cell number in human osteosarcoma U-2 OS cells through G2/M phase arrest and induction of cell apoptosis
Authors: Chen Chia-Ching , Chueh Fu-Shin , Peng Shu-Fen , Huang Wen-Wen , Tsai Chang-Hai , Tsai Fuu-Jen , Huang Chih-Yang , Tang Chih-Hsin , Yang Jai-Sing , Hsu Yuan-Man , Yin Mei-Chin , Huang Yi-Ping , Chung Jing-Gung 
Published: June 2019

ABSTRACT
Cantharidin (CTD), a sesquiterpenoid bioactive substance, has been reported to exhibit anticancer activity against various types of cancer cells. The aim of the present study was to investigate the apoptosis effects and the underlying mechanisms of CTD on osteosarcoma U-2 OS cells. Results showed that CTD induced cell morphologic changes, reduced total viable cells, induced DNA damage, and G2/M phase arrest. CTD increased the production of reactive oxygen species and Ca2+, and elevated the activities of caspase-3 and −9, but decreased the level of mitochondrial membrane potential. Furthermore, CTD increased the ROS- and ER stress-associated protein expressions and increased the levels of pro-apoptosis-associated proteins, but decreased that of anti-apoptosis-associated proteins. Based on these observations, we suggested that CTD decreased cell number through G2/M phase arrest and the induction of cell apoptosis in U-2 OS cells and CTD could be a potential candidate for osteosarcoma treatments.
Modelling a laser plasma accelerator driven free electron laser
Authors: Alotaibi B M , Khalil Sh M , McNeil B W J , Traczykowski Piotr 
Published: June 2019

Abstract
Free-electron lasers (FEL) are the brightest, coherent sources of short wavelength radiation from the VUV into the x-ray. There is much research interest in reducing the cost and the size of FELs by utilising new accelerator techniques. Laser-plasma accelerator (LPA) are a promising accelerator for next generation compact FEL light sources with many potential advantages due to the high acceleration gradient and large peak currents they offer. The electron beams of a LPA typically have a smaller transverse emittance, a large energy spread and tend to be of shorter duration and higher current than conventional Radio Frequency (RF) accelerators. In this paper, a FEL driven by an electron beam from a typical LPA was simulated using the 3D FEL simulation code Puffin. It is shown that lowering the homogenous electron beam energy spread increases the radiation energy output in a short undulator and , as become less than the FEL, or Pierce parameter (

ρ

), then the peak radiation energy increases and the saturation length reduces significantly as expected.
Bitter melon juice-intake modulates glucose metabolism and lactate efflux in tumors in its efficacy against pancreatic cancer
Authors: Dhar Deepanshi , Raina Komal , Kant Rama , Wempe Michael F , Serkova Natalie J , Agarwal Chapla , Agarwal Rajesh 
Published: June 2019

Abstract
The established role of bitter melon juice (BMJ), a natural product, in activating master metabolic regulator adenosine monophosphate-activated protein kinase in pancreatic cancer (PanC) cells served as a basis for pursuing deeper investigation into the underlying metabolic alterations leading to BMJ efficacy in PanC. We investigated the comparative metabolic profiles of PanC cells with differential KRAS mutational status on BMJ exposure. Specifically, we employed nuclear magnetic resonance (NMR) metabolomics and in vivo imaging platforms to understand the relevance of altered metabolism in PanC management by BMJ. Multinuclear NMR metabolomics was performed, as a function of time, post-BMJ treatment followed by partial least square discriminant analysis assessments on the quantitative metabolic data sets to visualize the treatment group clustering; altered glucose uptake, lactate export and energy state were identified as the key components responsible for cell death induction. We next employed PANC1 xenograft model for assessing in vivo BMJ efficacy against PanC. Positron emission tomography ([18FDG]-PET) and magnetic resonance imaging on PANC1 tumor-bearing animals reiterated the in vitro results, with BMJ-associated significant changes in tumor volumes, tumor cellularity and glucose uptake. Additional studies in BMJ-treated PanC cells and xenografts displayed a strong decrease in the expression of glucose and lactate transporters GLUT1 and MCT4, respectively, supporting their role in metabolic changes by BMJ. Collectively, these results highlight BMJ-induced modification in PanC metabolomics phenotype and establish primarily lactate efflux and glucose metabolism, specifically GLUT1 and MCT4 transporters, as the potential metabolic targets underlying BMJ efficacy in PanC.
Evolutionary Algorithms For k-Anonymity In Social Networks Based On Clustering Approach
Authors: Yazdanjue Navid , Fathian Mohammad , Amiri Babak 
Published: June 2019

AbstractThe usage of social networks shows a growing trend in recent years. Due to a large number of online social networking users, there is a lot of data within these networks. Recently, advances in technology have made it possible to extract useful information about individuals and the interactions among them. In parallel, several methods and techniques were proposed to preserve the users’ privacy through the anonymization of social network graphs. In this regard, the utilization of the k-anonymity method, where k is the required threshold of structural anonymity, is among the most useful techniques. In this technique, the nodes are clustered together to form the super-nodes of size at least k. Our main idea in this paper is, initially, to optimize the clustering process in the k-anonymity method by means of the particle swarm optimization (PSO) algorithm in order to minimize the normalized structural information loss (NSIL), which is equal to maximizing 1-NSIL. Although the proposed PSO-based method shows a higher convergence rate than the previously introduced genetic algorithm (GA) method, it did not provide a lower NSIL value. Therefore, in order to achieve the NSIL value provided by GA optimization while preserving the high convergence rate obtained from the PSO algorithm, we present hybrid solutions based on the GA and PSO algorithms. Eventually, in order to achieve indistinguishable nodes, the edge generalization process is employed based on their relationships. The simulation results demonstrate the efficiency of the proposed model to balance the maximized 1-NSIL and the algorithm’s convergence rate.