bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, Attitude and Associated Factors towards Safe Abortion among Private College Female Students of Gondar town, northwest Ethiopia: A cross sectional study
Authors: Mekonnen Birye Dessalegn , Wubneh Chalachew Adugna 
Published: October 2019

Abstract
Background: Unwanted pregnancies in youths and complications of induced abortions are an important health problem. Inadequate knowledge, unfavorable attitude towards safe abortion results in unsafe abortion. Most women die because of complications arising from unsafe abortion in developing countries are likely to have had little knowledge. Studies on knowledge, attitude and associated factors towards safe abortion among private college students are limited. Therefore, the aim of this study was to assess knowledge, attitude and associated factors towards safe abortion among private college female students in Gondar town, northwest EthiopiaMethods: An institution based cross-sectional study was conducted from April 30, 2019 to May 30, 2019 among private college students in Gondar town. Data were collected from 633female students using self-administered questionnaires by simple random sampling technique. Bivariable and multivariable logistic regression analysis was performed to identify association of dependent and independent variables using SPSS version 20.Result: A total of 633 respondents participated in this study with the response rate of 97.7%. Regarding the overall knowledge, 433(68.4%) of students had good knowledge towards safe abortion. Age (AOR= 2.81, 95% CI: 1.13, 7.47), residence (AOR=2.33, 95% CI: 1.22, 4.46), family education (AOR=3.29, 95% CI: 1.22, 6.46) and ever heard about safe abortion, (AOR=4.31, 95% CI: 1.79, 10.33) were factors associated with knowledge of students on safe abortion. Regarding attitude, 361 (57%) of students had favorable attitude towards safe abortion. Age (AOR=2.62, 95% CI: 1.70, 4.04) and residents (AOR=1.50, 95% CI: 1.04, 2.17) were factors significantly associated with attitude towards safe abortion.Conclusion: More than half of the participants have good knowledge and attitude towards safe abortion but still significant proportion of students have poor knowledge and unfavorable attitude. Information, Education and Communications programs on youth reproductive health should be provided to address topics on safe abortion for students. Forums and panel discussions on safe abortion need to be undertaken especially, among youths and students who came from rural area.
The transmission mode of Legionella from its source
Authors: Li Jun , Liu Lin , Li Kunquan , Li Xuebin , Tao Tao 
Published: October 2019

Abstract
BackgroundLegionella pneumonia has a fatality rate of 28%.Methodsmicroscope, fluorescence Quantitative Polymerase Chain Reaction (qPCR), force mathematical analysis.Results and ConclusionThe transmission mode of Legionella from its source was analyzed by microscope and qPCR. The Legionella removal efficiency by a membrane composed of water molecules was 94.5%, and Legionella had difficulty in penetrating through the surface of the water membrane. A deflection point at the interface between water and air indicated a cluster of Legionella that was bonded to the contact surface by some unknown emplastic media. Force analysis showed that the surface tension of water is 106 orders of magnitude larger than the net force from the sum of the buoyancy and the weight of Legionella, and revealed that the surface tension of water is so large that a Legionella bacterium cannot break away from the water surface membrane and escape. The qPCR results showed that no Legionella was found in the air from a Legionella incubator or the Legionella laboratory. The results demonstrate that Legionella cannot be transmitted to people through water vapor or aerosol. The experimental results also indicate that water was able to remove most Legionella bacteria.
Gender Differences in the Effect of Medical Humanities Program on Medical Students' Empathy: A Prospective Longitudinal Study
Authors: Lwow Michal , Canetti Laura , Muszkat Mordechai 
Published: October 2019

Abstract
Objective: Previous studies have suggested that Medical students' empathy declines during medical school, especially during clinical studies. The aim of this study was to examine whether humanities curriculum and admission system affect empathy changes during the first clinical year in medical school. Methods: In this prospective longitudinal study, 262 students were assessed during the fourth-year of medical school. Empathy was assessed before and at 4th-year-end, using the Jefferson Scale of Physician Empathy-Student Version (JSPE-S). The study included three cohorts, differing in humanities curriculum [limited Medical Humanities (MH(lim)) vs. extended Medical Humanities (MH(ext))], and in admission system [Personal Interview (PI) vs. multiple mini interviews (MMI)]. Results: Among women, but not among men, MH(ext) as compared to MH(lim) was associated with significantly higher JSPE-S at the beginning (118.47±11.43 vs. 110.36±9 .97, p<0.001), and end of 4th-year (117.97±12.86 vs. 111.49±14.42, p<0.001), (p=0.009). Admission system was not associated with JSPE-S at the beginning or at the end of the 4th year. Conclusion: Among women, extended MH program had a positive effect on empathy at the beginning of the first clinical year, as compared to the limited program. This effect persisted through that year. However, in men MH program did not affect empathy. Adopting MMI-based admission system had no measurable effect on students’ empathy. Extensive educational program can enhance and sustain empathy in medical students during the first clinical year following the program. Gender differences in response to medical humanities programs requires further study.
Nitric oxide is involved in the brassinolide-induced adventitious root development in cucumber (Cucumis sativus L.) explants
Authors: Yutong Li , Wu Yue , Liao Weibiao , Hu Linli , Dawuda Mohammed Mujitaba , Jin Xin , Tang Zhongqi , Yang Jianjun , Yu Jihua 
Published: October 2019

Abstract
Background: Brassinolide (BR), as a new type of plant hormones, is involved in the process of plant growth and stress response. Previous studies have reported the roles of BR in regulating plant developmental processes and also response tolerance to abiotic stresses in plants. In my study, the main purpose is to explore whether nitric oxide (NO) is involved in the process of BR-induced adventitious root formation in cucumber (Cucumis sativus L.), and whether it plays a certain role. Results: Exogenous application of 1 μM BR significantly promoted adventitious rooting, while high concentrations of BR (2-8 μM) effectively inhibited adventitious rooting. NO donor (S-nitroso-N-acerylpenicillamine, SNAP) promoted the occurrence of adventitious roots. Simultaneously, BR and SNAP mixed treatment significantly promoted adventitious rooting and the promoted effects was significantly superior to the application of BR or SNAP alone. Moreover, NO scavenger (c-PTIO) and inhibitors (L-NAME and Tungstate) inhibited the positive effects of BR on adventitious rooting. BR at 1 μM also increased endogenous NO content, NO synthase (NOS-like) and Nitrate reductase (NR) activities, while BRz (a specific BR biosynthesis inhibitor) decreased these effects. In addition, the relative expression level of NR was up-regulated by BR and SNAP, whereas BRz down-regulated it. The application of NO inhibitor (Tungstate) in BR also inhibited the up-regulation of NR. Conclusion: BR promoted the formation of adventitious roots via inducing the generation of endogenous NO.
Musculoskeletal pain and work-related risk factors among waste collectors in Hanoi, Vietnam: A cross-sectional study
Authors: Nguyen Bang Van , Tran Thuy , Hoang Ngan Thi , Nguyen Bich Ngoc , Nguyen Quynh Thuy` 
Published: October 2019

Abstract
Background: Musculoskeletal disorders are prevalent among waste collectors in developing countries. This study aimed to investigate the prevalence of musculoskeletal disorders and risk factors of persistent musculoskeletal disorders among waste collectors in Hanoi, Vietnam. Methods: A cross-sectional survey was utilized to study 331 waste collectors in 2017. The Örebro Musculoskeletal Pain Questionnaire and questionnaires on demographic and working conditions were used to collect data. Descriptive and linear regression analyses were applied at the significant level p<0.05. Results: Results showed that the prevalence of musculoskeletal disorders among waste collectors in Hanoi was high (100%), multiple-site musculoskeletal disorders (at least two sites) were reported by 81%. Lower back was the most affected site, followed by pain in the neck and shoulders. The risk of persistent musculoskeletal disorders were higher amongst female workers, workers with the neck bent at an angle of 45 0 , kneeling, repetitive medial rotation while walking, and feeling dissatisfaction with work, stress or anxiety during one week before the survey. Conclusions: Hanoian waste collectors were suffered from musculoskeletal disorders as the results of unfavorable work postures and psychological stress at work. The findings imply the need of mechanical and social support at work for waste collectors to prevent the development of musculoskeletal disorders.
Supporting children who have a parent with a mental illness in Tyrol: A situational analysis for informing co-development and implementation of practice changes
Authors: Zechmeister-Koss Ingrid , Goodyear Melinda , Tüchler Heinz , Paul Jean Lillian 
Published: October 2019

Abstract
Background: A research project aimed to improve the situation of children of parents with a mental illness (COPMI) has recently begun in the Austrian region of Tyrol. The project aims to strengthen formal and informal support structures around the child through enhancing their village of collaborative support. Understanding the current situation in the region is vital for implementing practice change. This paper aims to gain knowledge on the Tyrolean societal and service provision context. Methods: We collected qualitative and quantitative data on overall societal characteristics, epidemiology of mental illness in Tyrol, services that currently exist within adult mental health care and for supporting children, parents and families, uptake of services, and current practices and challenges of identifying and supporting COPMIs. We analysed data along several external context dimensions: 1) professional influences, 2) political support, 3) social climate, 4) local infrastructure, 5) policy and legal climate, 6) relational climate, 7) target population, 8) funding and economic climate. Results: While there is awareness of challenges related to COPMIs at professional and planning level, there is a lack of installed support processes and standards to meet their needs across Tyrol. A variety of services are available both for unwell parents, as well as for families and individual family members. Yet, only one small service addresses COPMIs directly. Services fall into different sectors (education, health, social affairs) and are funded from different sources, making coordination difficult. Access varies from universal to rather restricted (i.e. through referral). The potential number of parents to be reached via adult mental health, in order to identify their children, differs considerably by setting. Societal structures indicate that the informal and voluntary sector may be a realistic source for supporting COPMIs in Tyrol. Conclusions: The societal structures and the current services provide a rich resource for improving identification and supporting of COPMIs, however considerable coordination and behaviour change effort will be required due to the fragmentation of the system and professional cultures. The insights into the context of supporting COPMIs have been of high value for developing and implementing practice changes in the local organizations.
Effects of iron on the growth, biofilm formation and virulence of Klebsiella pneumoniae causing liver abscess
Authors: Chen Tao , Dong Guofeng , Zhang Siqin , Zhang Xiucai , Zhao Yajie , Cao Jianming , Zhou Tieli , Wu Qing 
Published: October 2019

Abstract
Background: Klebsiella pneumoniae is considered as the most clinically relevant species of Enterobacteriaceae, known to cause severe infections including liver abscesses. To the best of our knowledge,iron in human body primarily gathers in liver. Further understanding of effects of iron on K. pneumoniae causing liver abscess is a promising way to elucidate the mechanism of poor prognosis of liver abscess. Results: All tested K. pneumoniae including those collected from liver abscess and other sterile sites and K. pneumoniae ATCC 700603 cultured in LB broth containing 50 μM iron grew optimally and were in possession of the strongest biofilm formation ability, while worst growth and biofilm formation ability of the strains cultured in iron-deplete environment were observed. The infection model of G. mellonella larvae showed the virulence of K. pneumoniae cultured with additional iron was significantly higher than cultured with iron chelator (P<0.05). The relative expression level of the four siderophores genes (iucB, iroB, irp1, entB) in K. pneumoniae strains isolated from liver abscess cultured with additional iron was lower than that with iron chelator. Conclusions: It is suggested by our research that iron in the environment can promote the growth and enhance the biofilm formation ability of K. pneumoniae and the lower expression of siderophores genes may be one of the mechanisms of iron affecting the virulence of liver abscess-causing K. pneumoniae. Further deeper evaluation of these phenomenons is warranted.
Establishment and Validation of a Nomogram with Intratumoral Heterogeneity Derived from 18F-FDG PET/CT for Predicting Individual Conditional Risk of 5-Year Recurrence before Initial Treatment of Nasopharyngeal Carcinoma
Authors: Gu Bingxin , Ma Guang , Song Shaoli , Shi Liqun , Zhang Yingjian , Zhang JianPing , Yang Zhongyi 
Published: October 2019

Abstract
Objectives Intratumoral heterogeneity has an enormous effect on patient treatment and outcome. The purpose of the current study was to establish and validate a nomogram with intratumoral heterogeneity derived from 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for prognosis of 5-Year progression-free survival (PFS) of patients with nasopharyngeal carcinoma (NPC).Methods A total of 171 NPC patients who underwent pretreatment 18F-FDG PET/CT were retrospectively enrolled. Data was randomly divided into training cohort (n=101) and validation cohort (n=70). The clinicopathologic parameters and the following PET parameters were analyzed: maximum and mean standardized uptake value (SUVmax, SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and heterogeneity index (HI, SUVmax/SUVmean) for primary tumor and maximal neck lymph node. Cox analyses were performed on PFS in the training cohort. A prognostic nomogram based on this model was developed and validated.Results For the primary tumor, MTV-2.5, TLG-2.5, MTV-70%, and TLG-70% were significantly correlated with PFS. For the maximal neck lymph node, short diameter and HI were significantly correlated with PFS. Among the clinicopathologic parameters, M stage was a significant prognostic factor for recurrence. In multivariate analysis, M stage (P=0.006), TLG-T-70% (P=0.002), and HI-N (P=0.018) were independent predictors. Based on this prognostic model, a nomogram was generated. Patients with a risk score of ≥111 had poorer survival outcomes than those with a risk score of 0-76 and 77-110.Conclusions Intratumoral heterogeneity derived from 18F-FDG PET/CT could predict long-term outcome in patients with primary NPC. A combination of PET parameters and the TNM stage enables better stratification of patients into subgroups with different PFS rates.
Comprehensive Network Analysis of the Molecular Mechanisms Associated with Sorafenib Resistance in Hepatocellular Carcinoma
Authors: Cui Xiang , Li Chao , Wei Chunshan , Tong Guangdong , Xing Yufeng 
Published: October 2019

Abstract
Background: This research aimed to investigate the potential molecular mechanism of sorafenib resistance to hepatocellular carcinoma (HCC). Methods: Differential expression analysis were performed to identified differentially expressed genes (DEGs) in sorafenib resistant HCC. Then, a series of bioinformatic analysis were performed to explore the potential crucial molecules in sorafenib resistant HCC. For example, gene function annotation, pivot regulators prediction, ROC analysis and survival analysis. Results: There were 827 differentially expressed genes were identified. Moreover, most of the differentially expressed genes are involved in immune and inflammatory-related functions and signaling pathways. Also, 18 transcription factors were predicted to regulate the transcription factors of differentially expressed genes, which play an essential role in the regulation of dysfunctional gene networks. In target genes of transcription factors, CDK1 and CDKN1A have high diagnostic value in the resistance of hepatocellular carcinoma to sorafenib. Conclusions: TAPBP has the strongest correlation with drug resistance of hepatocellular carcinoma and the highest diagnostic efficiency. In addition, CDK1 and CDKN1A have high diagnostic value in the resistance of hepatocellular carcinoma to sorafenib. Overall, our analysis shows that a large number of gene disorders occur during the development of resistance to sorafenib in hepatocellular carcinoma, and they are associated with immune and inflammatory reactions in the body. These results provide critical theoretical references for the pathogenesis and diagnosis of sorafenib resistance.
Soil Chemical Attributes, Soil Type, and Rainfall Effects on Normalized Difference Vegetation Index and Cotton Fiber Yield Variability
Authors: Rojo Baio Fabio Henrique , Neves Danilo Carvalho , Teodoro Paulo Eduardo 
Published: October 2019

Understanding of how crop yield is influenced by interactions between the soil and environment is needed to minimize agricultural inputs and reduce the impacts of agriculture on the environment. The objective of this study was to determine the effect of soil chemical attributes, soil type, and rainfall on cotton (Gossypium hirsutum L.) yields and yield variability. In this study, the average cotton fiber yield was collected from 101 fields over nine crop seasons. In these fields, located in central Brazil, the average and standard deviation of normalized difference vegetation index (NDVI) were determined. Growing season rainfall and soil nutrients were measured. The variables analyzed were: average cotton fiber yield, NDVI from Landsat images calculated at the boll development phenological stage (enlargement and fiber filling phases), CV of the NDVI, precipitation during the cycle, and soil chemical attributes. The average field NDVI values collected at the boll development phenological stage were correlated to yield (r = 0.50; p < 0.05). Fields with a higher CV for the NDVI values generally had lower yields. The effect of precipitation depends on the cotton phenological stage and soil type. A high rainfall volume at the beginning of the cropping cycle increased plant height variability, which harmed the cotton fiber yield. The highest average values of aluminum content, aluminum saturation, and potential acidity promoted variability in cotton plant growth. Soil chemical attributes related to aluminum were negatively correlated with yield (r = −0.34; p > 0.05).Core Ideas

Annual averages of NDVI and yield presented a significant correlation.
The effect of precipitation depends on the cotton phenological stage and soil type.
Soil chemical variables related to aluminium are negatively correlated with the yield.
Investigation of Data Assimilation Methods for Soil Parameter Estimation with Different Types of Data
Authors: Zha Yuanyuan , Zhu Penghui , Zhang Qiuru , Mao Wei , Shi Liangsheng 
Published: October 2019

Core Ideas
Groundwater level data require EnRML for better interpretation.
Different methods perform similarly when assimilating surface soil moisture data.
Soil water pressure head data are the most valuable in terms of parameter estimation.
MCMC performs well in homogeneous soil but degrades in heterogeneous soil.
The EnKF method relies more on a relatively large number of ensembles than does EnRML.
In the past few decades, different data assimilation methods have been proposed to estimate soil parameters. It is not clear whether a straightforward sampling approach is sufficient or whether a linear filter or even an advanced nonlinear filter is needed to interpret the potential information carried by different data types (e.g., pressure head and water content data from multiple depths, easily available surface soil moisture data, and groundwater level data). In this study, three classical data assimilation methods, i.e., the ensemble Kalman filter (EnKF), the ensemble randomized maximum likelihood filter (EnRML), and the Markov chain Monte Carlo (MCMC), were investigated numerically in terms of the utility to cope with three different types of observations. Results show that, compared with the EnKF approach, EnRML is a superior method to extract the parameter information from observations. The MCMC approach performs well in homogeneous soil but not in heterogeneous soil. Regardless of the data assimilation methods and the soil heterogeneity, point‐scale soil water pressure head data are the most valuable in terms of soil parameter estimation, followed by groundwater level data, which require a nonlinear filter to interpret. A smaller observation error for groundwater level data leads to obviously improved parameter estimates by using EnRML with a slight improvement by using EnKF. The stable performance of the EnKF method relies more heavily on a relatively large number of ensembles than the EnRML method, whereas only a few ensemble members are needed for EnRML in a homogeneous soil column.
Can Drip Irrigation be Scheduled with Cosmic‐Ray Neutron Sensing?
Authors: Li Dazhi , Schrön Martin , Köhli Markus , Bogena Heye , Weimar Jannis , Jiménez Bello Miguel Angel , Han Xujun , Martínez Gimeno Maria Amparo , Zacharias Steffen , Vereecken Harry , Hendricks Franssen Harrie‐Jan 
Published: October 2019

Core Ideas
Cosmic‐ray neutron sensing (CRNS) was used in a drip‐irrigated field.
Soil water content was estimated from CRNS.
Neutron transport was simulated for the drip‐irrigated field.
CRNS has limitations for irrigation scheduling of drip‐irrigated fields.
Irrigation is essential for maintaining food production in water‐scarce regions. The irrigation need depends on the water content of the soil, which we measured with the novel technique of cosmic‐ray neutron sensing (CRNS). The potential of the CRNS technique for drip irrigation scheduling was explored in this study for the Picassent site near Valencia, Spain. To support the experimental evidence, the neutron transport simulation URANOS was used to simulate the effect of drip irrigation on the neutron counts. The overall soil water content (SWC) in the CRNS footprint was characterized with a root mean square error <0.03 cm3/cm3, but the experimental dataset indicated methodological limitations to detect drip water input. Both experimental data and simulation results suggest that the large‐area neutron response to drip irrigation is insignificant in our specific case using a standard CRNS probe. Because of the small area of irrigated patches and short irrigation time, the limited SWC changes due to drip irrigation were not visible from the measured neutron intensity changes. Our study shows that CRNS modeling can be used to assess the suitability of the CRNS technique for certain applications. While the standard CRNS probe was not able to detect small‐scale drip irrigation patterns, the method might be applicable for larger irrigated areas, in drier regions, and for longer and more intense irrigation periods. Since statistical noise is the main limitation of the CRNS measurement, the capability of the instrument could be improved in future studies by larger and more efficient neutron detectors.