bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban Places as Aesthetic Phenomena: Framework for a Place-Based Ontology of Urban Lifeworld
Authors: Vihanninjoki Vesa 
Published: January 2019

AbstractUrban places are of central significance for cities both as built structures and as centers of everyday life. Due to the emergence of various design-led place-making policies and practices, “urban place” has largely become a marketed and branded product. Aesthetics plays a major role in this project of place-making, and the related interpretation of “commodified aesthetics of place” emphasizes certain experiential and qualitative place-attributes—such as authenticity—despite apparent conceptual confusions and controversies. A thorough reconsideration of central place-concepts is required to shed light on this problematic sphere. This article provides an alternative reading of urban places and the related aesthetic dimensions, based primarily on a Heideggerian account of human existence as placed being in the world. Such an approach emphasizes the decisive difference between an object-based and a contextual interpretation of place, providing also a framework for understanding the aesthetics of place and its fundamental lifeworld-constituting role anew.
A rare missense variant of CASP7 is associated with familial late‐onset Alzheimer's disease
Authors: Zhang Xiaoling , Zhu Congcong , Beecham Gary , Vardarajan Badri N. , Ma Yiyi , Lancour Daniel , Farrell John J. , Chung Jaeyoon ,   Alzheimer's Disease Sequencing Project, Mayeux Richard , Haines Jonathan , Schellenberg Gerard , Pericak‐Vance Margaret , Lunetta Kathy , Farrer Lindsay 
Published: January 2019

AbstractIntroductionThe genetic architecture of Alzheimer's disease (AD) is only partially understood.MethodsWe conducted an association study for AD using whole sequence data from 507 genetically enriched AD cases (i.e., cases having close relatives affected by AD) and 4917 cognitively healthy controls of European ancestry (EA) and 172 enriched cases and 179 controls of Caribbean Hispanic ancestry. Confirmation of top findings from stage 1 was sought in two family‐based genome‐wide association study data sets and in a whole genome–sequencing data set comprising members from 42 EA and 115 Caribbean Hispanic families.ResultsWe identified associations in EAs with variants in 12 novel loci. The most robust finding is a rare CASP7 missense variant (rs116437863; P = 2.44 × 10−10) which improved when combined with results from stage 2 data sets (P = 1.92 × 10−10).DiscussionOur study demonstrated that an enriched case design can strengthen genetic signals, thus allowing detection of associations that would otherwise be missed in a traditional case‐control study.
Determining the utility of standard hospital microbiology testing: Comparing standard microbiology cultures with DNA sequence analysis in patients with chronic sinusitis
Authors: Rapoport Sarah K. , Smith Alyssa J. , Bergman Maxwell , Scriven Kelly A. , Brook Itzhak , Mikula Suzette K. 
Published: January 2019

ObjectiveTo demonstrate DNA sequencing analysis (DNAsa) of sinus cultures in patients with CRS is a reliable method of detecting pathogens in polymicrobial CRS infections.MethodsAfter obtaining Institutional Review Board approval for this prospective cohort study, we selected a random sample of 50 patients with CRS at Medstar Georgetown University Hospital between September 2016 and March 2017. We defined CRS as a history of rhinosinusitis refractory to maximal medical therapy and prior endoscopic sinus surgery. Patients demonstrating active purulence in a sinus cavity were prospectively selected to undergo standard hospital cultures (SHC) and DNAsa cultures. Organisms identified in both methods were compared for each patient.ResultsSpecimens were obtained from 29 female and 16 male patients with a mean age of 50 years. A total of 45 cultures were included in our final analysis; five cultures were excluded after inappropriate laboratory processing. Results from these patients were compared and analyzed. Cohen's weighted kappa analysis showed agreement between the two testing methods in identifying predominant microorganisms. DNAsa detected 31.9% more microorganisms compared to SHC (P < 0.05). When multiple microorganisms were detected, DNAsa yielded more positive results compared to SHC (P < 0.05).ConclusionsDNAsa detects all microorganisms identified by SHC as well as predominant microorganisms not detected by SHC. Thus molecular pathogen identification may be more reliable for identifying multiple microorganisms as compared to standard culture techniques that identify only one or two microorganisms. In recalcitrant cases of CRS, DNAsa may provide better guidance in selection of appropriate antimicrobial treatment.
Bem Study of 3D Heat Conduction in Multiply Adjoined Anisotropic Media with Quadratic Domain Heat Generation
Authors: Tuan N. A. , Shiah Y. C. 
Published: January 2019

ABSTRACTIn engineering, it is quite often to have applications of the heat transfer of conduction having domain heat generation present inside. The paper aims to present boundary element formulations for analyzing the three-dimensional heat-conduction in dissimilarly bonded anisotropic media involving quadratic volume heat sources. In this paper, the additional volume integral present in the boundary integral equation is analytically transformed to the boundary surface for the volume heat sources modeled by quadratic functions. The technique of domain-mapping is employed to treat the three-dimensional anisotropic heat conduction in multiply adjoined media with proper interfacial conditions provided. For showing our successful implementation, a few example cases are analyzed with verification of independent analyses by the finite element method.
Refining the Paleo-Aleut to Neo-Aleut transition using a new ΔR for the eastern Aleutian Islands, Alaska
Authors: West Dixie , Khasanov Bulat , Krylovich Olga , Hatfield Virginia , Khasanov Timur , Vasyukov Dmitry , Savinetsky Arkady 
Published: January 2019

AbstractUsing six paired terrestrial and marine organics collected in the Islands of Four Mountains, Alaska, we present a new regional correction factor, ΔR (495±20 yr), for the eastern Aleutians. We compare our ΔR with previous North Pacific marine corrections. Using the ΔR for the eastern Aleutians, we calibrated the radiocarbon dates of 80 human skeletons recovered from village site Chaluka and cave burials at Ship Rock and Kagamil Islands. These burial places contain two morphologically and genetically distinct humans—an early form called Paleo-Aleut and a later form called Neo-Aleut. Researchers have contested (1) the timing of Neo-Aleut movements into the Aleutians, and (2) Neo-Aleut interactions with Paleo-Aleuts. Our recalibrations indicate that the oldest Paleo-Aleut burial (1135 BC) occurred at Chaluka and the youngest Paleo-Aleut cave burial occurred at Kagamil during the fourteenth century (AD 1305). Neo-Aleuts buried their dead at Chaluka by AD 1375. The oldest definitive Neo-Aleut cave burial occurred during the fifteenth century (AD 1420) at Ship Rock. Eastern Aleuts buried their dead in caves for centuries, with the youngest Neo-Aleut buried at Kagamil circa AD 1865.
Democracy's Deficit: The Role of Institutional Contact in Shaping non-White Political Behavior
Authors: García-Castañon Marcela , Huckle Kiku , Walker Hannah L. , Chong Chinbo 
Published: January 2019

AbstractThis paper examines the effect of institutional contact on political participation among non-White communities. While both formal and informal institutions help shape community citizen participation, their effects vary on the historical inclusion (or exclusion) of certain racial groups. Formal institutions, like political parties, have historically excluded or neglected non-White and immigrant voters. We argue that for the excluded or neglected, non-traditional political institutions, like community based organizations, serve as supplements to facilitate political incorporation and engagement. These informal institutions help develop skills and resources among their constituents, and offer routine opportunities to participate. We use the 2008 Collaborative Multi-racial Post-Election Survey (CMPS) to test the differential effects of self-reported voter mobilization through nonpartisan and partisan institutional contact to explain variations among racial groups by the intensity of contact, occurrence of co-ethnic outreach, and type of institutional mobilization. We find that while contact by a partisan/political institution, like a political party or campaign, has an overall positive effect on political participation for all voters, contact by a nonpartisan/civic or community group is substantively more important for Latino and Asian American voter mobilization. Our analysis therefore offers cohesive evidence of how voters interact with and are affected by mobilization efforts that attends to differences across racial and ethnic boundaries, and variations in institutional contact.
Lessons from the English auxiliary system
Authors: SAG IVAN A. , CHAVES RUI P. , ABEILLÉ ANNE , ESTIGARRIBIA BRUNO , FLICKINGER DAN , KAY PAUL , MICHAELIS LAURA A. , MÜLLER STEFAN , PULLUM GEOFFREY K. , VAN EYNDE FRANK , WASOW THOMAS 
Published: January 2019

The English auxiliary system exhibits many lexical exceptions and subregularities, and considerable dialectal variation, all of which are frequently omitted from generative analyses and discussions. This paper presents a detailed, movement-free account of the English Auxiliary System within Sign-Based Construction Grammar (Sag 2010, Michaelis 2011, Boas & Sag 2012) that utilizes techniques of lexicalist and construction-based analysis. The resulting conception of linguistic knowledge involves constraints that license hierarchical structures directly (as in context-free grammar), rather than by appeal to mappings over such structures. This allows English auxiliaries to be modeled as a class of verbs whose behavior is governed by general and class-specific constraints. Central to this account is a novel use of the featureaux, which is set both constructionally and lexically, allowing for a complex interplay between various grammatical constraints that captures a wide range of exceptional patterns, most notably the vexing distribution of unstresseddo, and the fact that Ellipsis can interact with other aspects of the analysis to produce the feeding and blocking relations that are needed to generate the complex facts of EAS. The present approach, superior both descriptively and theoretically to existing transformational approaches, also serves to undermine views of the biology of language and acquisition such as Berwick et al. (2011), which are centered on mappings that manipulate hierarchical phrase structures in a structure-dependent fashion.
Dirty, soothing, secret magic: individualism and spirituality in New Age and extreme metal music cultures
Authors: Coggins Owen 
Published: January 2019

AbstractTaking inspiration from a press article comparing doom metal and New Age music, I explore individualism and magic in these musical cultures, reflecting on the ‘dirty, soothing secret’ suggested in that article's title. I trace the loosely defined characteristics of New Age music in the limited academic research on the topic, before situating the music in the wider New Age milieu which centres around the epistemological authority of the seeking self among diverse spiritual resources. Then, I examine the claims made about metal in the news article, drawing out themes which also relate to individualism and magic. Finally, I return to the concepts of the dirty, the soothing and the secret, arguing that these are not merely incidental aspects of the mainstream reception of New Age and metal music, but in fact can be understood as contributing to the magical potential of such music for listeners.
‘More powerful than politics’: Affective magic in the DIY musical activism after Egypt's 2011 Revolution
Authors: Sprengel Darci 
Published: January 2019

AbstractWith a return to authoritarian rule only a few years after the initially successful 2011 revolution, some Egyptian DIY musicians have made it a point to avoid the political. These musicians consider the ordinary politics of discursive critique and public protest to be ineffective and have opted to continue the revolution by appealing to the ineffable properties of listening as a less ideologically driven way to produce social change. This article explores how and why the sonic ineffable is believed to be a more utopian form of politics. It argues that mobilizing ‘magic’ is a particularly positioned solution to political failure that obscures the relations of power it perpetuates. Building from 30 months of ethnographic research conducted in Egypt among DIY musicians between 2010 and 2017, it avoids a romanticisation of the ineffable, showing instead how utilising the ambiguity between the conscious and subconscious aspects of sonic experience is a political tool not removed from power.
Sound, music and magic in football stadiums
Authors: Marra Pedro Silva , Trotta Felipe 
Published: January 2019

AbstractThis article discusses the role of music performance in football matches, highlighting the importance of the belief in its sonic powers as a trigger for causal relations between events. Music functions as a communicational axis linking the physical realm to mystical or intangible dimensions. By performing music and sounds on terraces, fans believe that they can change the course of the match, interfering in the mood, the bodies and, eventually, the result. Magic is a shared belief among fans, players and journalists, one that is activated through sounds and rituals. In football, the idea of magic is often perceived and referred to as a causal explanation for achievements and defeats that could hardly be understood or explained through rational and scientific knowledge. Music is a key feature in this process.
‘Conjuring some magic’: paganism and the musical and visual aesthetics of Florence + the Machine and Bat for Lashes
Authors: Smith Erin Sweeney 
Published: January 2019

AbstractMagic and mystery shroud Florence + the Machine's and Bat for Lashes's performances and interviews, which frequently frame the two groups’ frontwomen, Florence Welch and Natasha Khan, as ‘witchy’ or magical, or spur comparisons to Pagan aesthetics. This article investigates the unique ways the two bands use Pagan influences to speak to mainstream and Pagan audiences. Ultimately, the two groups set themselves apart from other bands through marketing that fuses commercialism with an esoteric religion. Florence + the Machine and Bat for Lashes create a ‘Pagan chic’ that draws in listeners through videos, instrumentation often featuring harp and tom-tom drums, fantasy-oriented lyrics, and stage props which use a Pagan lens to respond to current political events reminiscent of the counterculture of the 1960s and 1970s.
OP04 Cardiac Implant Registries: Systematic Review Of Global Practices
Authors: Kolominsky-Rabas Peter , Zhang Shixuan , Gaiser Sebastian 
Published: January 2019

Introduction:The importance of Cardiac Implant Registry (CIR) for ensuring a long-term follow-up in post-marked surveillance has been recognized and approved, but there is a lack of consensus standards on how to establish a CIR. The aim of this study is to investigate the structure and key elements of CIRs in the past decade (2006–2016) and to provide recommendations on “best practice” approaches.Methods:A systematic search on CIR was employed in line with the PRISMA guidelines. The following databases were searched: the PubMed (Medline), ScienceDirect, EMBASE and the Scopus database. After identifying the existing CIR, an inductive approach was used to explore key elements emerging in the identified registries.Results:The following eighty-two registries were identified: eighteen ICD registries, seven CRT registries, five pacemaker registries, and six Cardiovascular Implantable Electronic Device (CIED) registries which combined ICD, pacemaker and CRT implantation data; as well as twenty-two coronary stent registries and twenty-four TAVI registries. While seventy-one national or local registries are from a single country, forty-four are from European countries, and nine are located in USA. The following criteria have been summarized from the identified registries, including: registry working group, ethic issues, transparency, research objective, inclusion criteria, compulsory participation, endpoint, sample size, data collection basement, data collection methods, data entry, data validation and statistical analysis.Conclusions:For HTA as well as regulatory decision making, medical device registries provide a “real-world” picture for patients, physicians, manufacturers, payers, decision-makers and other stakeholders. CIRs are important for regulatory decisions concerning the safety and approval issues of medical devices; for payers CIRs provide evidence on the medical device benefits and drive the decision as to whether the product should be reimbursed or not; for hospitals data from CIRs are important for sound procurement decisions, and CIRs also help patients and their physicians to reach a joint decision on which of the products is the most appropriate. However, many current CIRs are still lacking standards to inform on patient safety and ensure transparency.
OP13 2017 Health Technology Assessment International Asia Policy Forum: The Perspective Of Not-For-Profit Members
Authors: Pwu Raoh-Fang , Trowman Rebecca 
Published: January 2019

Introduction:The fifth Health Technology Assessment International (HTAi) Asia Policy Forum (APF) was held in Beijing, November 2017. The topic of the meeting was ‘Universal Health Care in the Asia Region: Overcoming the Barriers using HTA and Real World Data’. This presentation will focus on the use of real world data (RWD) as a mechanism of informing HTA in the Asia region – from the perspective of the not-for-profit HTA agencies that were represented at the APF.Methods:The 2017 HTAi APF had senior representatives from government and HTA agencies from 11 countries in the Asia region. This included first-time attendees from Iran, Indonesia and the Philippines. A keynote presentation on the lessons learnt from Taiwan on the use of RWD was delivered, and there were guided breakout group discussions.Results:There are a number of registries and sources of RWD available to the HTA agencies across the Asia region. However it was noted that the databases are resource intensive to maintain, and there are noted time lags in the data collection and release. There are examples where the data from these sources have been used to evaluate local utilization of treatments and post-market surveillance, but it has not yet been used in pricing/reimbursement decisions.Conclusions:Although RWD could be a good tool for healthcare decision-making in the Asia region, it is still unclear how to do so properly. Infrastructure and human capacity, as well as law, are key factors to the successful use of RWD. Standardized methodologies, increased transparency, quality control and capacity building are essential elements to better implementing RWD in HTA.
OP15 Actions Arising From The 2017 Health Technology Assessment International Asia Policy Forum
Authors: Kearney Brendon , Trowman Rebecca 
Published: January 2019

Introduction:Universal health care (UHC) leads to better health, educational outcomes and productivity. However, Asian healthcare systems are experiencing huge pressures and are striving to achieve UHC. With this in mind, the Health Technology Assessment International (HTAi) Asia Policy Forum (APF) tackled, ‘Universal Health Care in the Asia Region: Overcoming the Barriers using HTA and Real World Data (RWD)’.Methods:The HTAi APF convened forty-four senior representatives from HTA agencies and industry from Asia. Through a mixture of keynote presentations and guided group discussions, APF members spent two days grappling with the topic.Results:There were a number of key messages from the APF, plus actions that were identified by APF members. The actions included: (i) A standardized HTA methodology for the prioritization of technologies in the Asia region should be developed to support health care systems; (ii) HTAi need to define what real-world data means in the HTA glossary; (iii) Members of the APF should develop a catalogue of what public and private data is available across countries in the region; (iv) A policy statement that agencies can use with a common approach to the release of data needs to be developed.Conclusions:HTA and access to RWD were identified as essential tools to be used in achieving the goal of UHC; this goal should indeed be pursued in the Asia region. However, issues such as transparency and accountability of HTA, and trust and collaboration between the public and private sectors are important concerns which need to be addressed in order to progress this goal. The recommendations for actions resulting from this successful APF update on progress towards these identified actions will be presented.
OP16 Decision Criteria That Influence Managed Entry Agreements
Authors: Freeman-Robinson Maxine , Mihalopoulos Cathrine , Merlin Tracy , Roughead Elizabeth 
Published: January 2019

Introduction:Managed Entry Agreements (MEAs) enable payers to subsidize access to new medicines while addressing uncertainties. Uncertainties may relate to the criteria for decision-making articulated in decision-making frameworks. The study's aim was to determine if there was any association between the type of MEA and criteria considered during decision-making.Methods:All medicines with MEAs listed on the Australian national subsidy scheme between 2012-2016 were identified. Data were extracted on the types of MEA and information related to the criteria considered in decision-making for each medicine and its associated indication (i.e. a medicine-indication pair [MIP]). The criteria considered in decision-making included the comparator (therapy to which it was compared), type of economic analysis, accepted value, budget impact, financial cost of supply, cost of therapy per patient, access control (such as restrictions or prior authorization), and clinical need. Associations between types of MEA and the criteria were assessed using Chi Squared test.Results:There were 87 MIPs, of which 56 had only financial MEAs and 31 had performance-based MEAs. Coverage with evidence development MEAs had very high incremental cost-effectiveness ratio (ICER)/quality adjusted life year (QALY) (74 percent > AUD 50,000 [USD 37,822]). Financial MEAs where performance measures were linked to reimbursement had lower ICER/QALY (13 percent > AUD 50,000 [USD 37,822]) but greater budget impact (33% > AUD 80million [USD 60.5million]) compared to simple financial MEAs. A statistically significant association (Cramer's V = 0.5, p < 0.001) was only found between performance-based MEAs and the cost of unsubsidized therapy per patient.Conclusions:The main influence on the choice of performance based MEA was the provision of access to clinically important medicines with a high treatment cost for patients.