bluuebunny/crossref_metadata_2025_split huggingface dataset:
OPTY-LINE remote-controlled adjustable intramedullary device implantation in open-wedge high tibial osteotomy: A prospective proof-of-concept pilot and comparison with Tomofix fixed-plate device method
Authors: Jonker Leon , Fallahi Farshid , Saraswathy Jayadeep J , Edge John , Dawson Matt 
Published: August 2019

Purpose: The objective was to evaluate the clinical and patient-related short- to medium-term performance of the OPTY-LINE nail device for high tibial osteotomy (HTO), comparing a case series of the said device to the established Tomofix fixed-plate device. Patients and Methods: Males with symptomatic medial compartmental osteoarthritis and no serious (co-morbid) knee pathology were followed up, five Tomofix and six OPTY-LINE patients. Patients underwent computed tomography assessment and completed Knee Injury and Osteoarthritis Outcome score (KOOS) and osteotomy surgery patient satisfaction questionnaires, 3 and 6 months post-surgery. A radiologist impression score and a quantitative digital bone density analysis were performed by two independent radiologists. Mann–Whitney U test was applied for inferential statistical tests. Results: At 6 months post-surgery, for Tomofix, the median radiologists’ healing impression score was ‘progressive healing’ versus ‘union virtually complete’ for the OPTY-LINE nail; bone healing quotient was 1.30 (standard deviation (SD) 1.74) versus 1.78 (SD 1.58), p = 0.18. The post-operative absolute surgical accuracy was a mean 12 (7.5) for Tomofix versus 4.1 (2.3) for OPTY-LINE, p = 0.052. At baseline, however, Tomofix patients had more knee symptoms, as determined by KOOS symptom sub-score, when compared to the OPTY-LINE cohort ( p = 0.009). Conclusion: This initial, non-randomized, comparative evaluation of the OPTY-LINE device for HTO has produced similar outcomes to patients treated with the established Tomofix device. In particular, the rate of post-surgical bone regeneration and surgical accuracy achieved with the OPTY-LINE device are encouraging. Large-scale randomized controlled studies with longer follow-up are indicated to further evaluate the clinical and patient-related outcome performance for OPTY-LINE.
Ponatinib treatment promotes arterial thrombosis and hyperactive platelets
Authors: Merkulova Alona , Mitchell Steven C. , Stavrou Evi X. , Forbes Gabriel L. , Schmaier Alvin H. 
Published: August 2019

Key Points
Ponatinib therapy heightens arterial thrombosis and platelet reactivity. Concurrent pioglitazone treatment reverses heightened thrombosis risk and platelet reactivity induced by ponatinib.
Xpert MTB/RIF performance to diagnose tuberculosis and rifampicin resistance in a reference centre in southern Brazil
Authors: Feliciano Cinara Silva , Menon Lucas José Bazzo , Anselmo Livia Maria Pala , Dippenaar Anzaan , Warren Robin Mark , Silva Wilson Araújo , Bollela Valdes Roberto 
Published: August 2019

Effective treatment of tuberculosis (TB) remains a serious public health problem in many countries, including Brazil, especially when considering drug-resistant disease. Xpert MTB/RIF has been implemented in many countries to reduce the time to TB diagnosis and to rapidly detect rifampicin resistance. The study aimed to describe and evaluate Xpert MTB/RIF performance in diagnosing pulmonary TB and rifampicin resistance in a tertiary healthcare facility in Brazil.A cross-sectional study was performed, which included all isolates of confirmed pulmonary TB patients from 2015 to 2018. Both Xpert MTB/RIF and GenoType MTBDRplusassays were performed to detect rifampicin and isoniazid resistance. In addition, isolates with detected resistance to rifampicin and/or isoniazid were analysed by phenotypic testing using MGIT-960 SIRE kit and whole-genome sequencing (WGS) using Illumina MiSeq Sequencing System.2148 respiratory specimens tested with Xpert MTB/RIF were included: n=1556 sputum, n=348 bronchoalveolar lavage and n=244 gastric washing. The overall Xpert MTB/RIF sensitivity in sputum was 94% and the overall specificity was 98%. The negative predictive value in sputum of all the patients was 99% with a positive predictive value of 89%. The concordance between Xpert MTB/RIF and phenotypic susceptibility test was 94.1%, while its concordance with WGS was 78.9%.Xpert MTB/RIF is a rapid and accurate diagnostic strategy for pulmonary TB, which can contribute to improvement in TB control. However, detection of rifampicin resistance might be associated with false-positive results.
A specific proteinase 3 activity footprint in α1-antitrypsin deficiency
Authors: Newby Paul R. , Crossley Diana , Crisford Helena , Stockley James A. , Mumford Richard A. , Carter Richard I. , Bolton Charlotte E. , Hopkinson Nicholas S. , Mahadeva Ravi , Steiner Michael C. , Wilkinson Tom M.A. , Sapey Elizabeth , Stockley Robert A. 
Published: August 2019

α1-Antitrypsin (α1-AT) deficiency is a risk factor for emphysema due to tissue damage by serine proteases. Neutrophil elastase (NE) has long been considered the enzyme responsible. However, proteinase 3 (PR3) also produces the pathological features of chronic obstructive pulmonary disease (COPD), is present in the same granules in the neutrophil and is inhibited after NE. We developed a specific footprint assay for PR3 activity and assessed its relationship to an NE footprint in α1-AT deficiency.An ELISA was developed for the specific PR3 fibrinogen cleavage site Aα-Val541. Levels were measured in plasma from 239 PiZZ patients, 94 PiSZ patients, 53 nondeficient healthy smokers and 78 individuals with usual COPD. Subjects underwent extensive demographic characterisation including full lung function and lung computed tomography scanning.Aα-Val541was greater than the NE footprint in all cohorts, consistent with differential activity. Values were highest in the PiZZ α1-AT-deficient patients and correlated with the NE marker Aα-Val360, but were ∼17 times higher than for the NE footprint, consistent with a greater potential contribution to lung damage. Aα-Val541was related cross-sectionally to the severity of lung disease (forced expiratory volume in 1 s % pred: rs= −0.284; p<0.001) and was sensitive to augmentation therapy, falling from 287.2 to 48.6 nM (p<0.001).Anin vivoplasma footprint of PR3 activity is present in greater quantities than an NE footprint in patients with α1-AT deficiency, is sensitive to augmentation therapy and represents a likely biomarker for dose-ranging studies.
The conserved actinobacterial transcriptional regulator FtsR controls expression of ftsZ and further target genes and influences growth and cell division in Corynebacterium glutamicum
Authors: Kraxner Kim Julia , Polen Tino , Baumgart Meike , Bott Michael 
Published: August 2019

AbstractBackgroundKey mechanisms of cell division and its regulation are well understood in model bacteria such asEscherichia coliandBacillus subtilis.In contrast, current knowledge on the regulation of cell division inActinobacteriais rather limited. FtsZ is one of the key players in this process, but nothing is known about its transcriptional regulation inCorynebacterium glutamicum,a model organism of theCorynebacteriales.ResultsIn this study, we used DNA affinity chromatography to search for transcriptional regulators offtsZinC. glutamicumand identified the Cg1631 protein as candidate, which was named FtsR. Both deletion and overexpression offtsRcaused growth defects and an altered cell morphology. Plasmid-based expression of nativeftsRor of homologs of the pathogenic relativesCorynebacterium diphtheriaeandMycobacterium tuberculosisin the ΔftsRmutant could at least partially reverse the mutant phenotype. Absence offtsRcaused decreased expression offtsZ, in line with an activator function of FtsR. In vivo crosslinking followed by affinity purification of FtsR and next generation sequencing of the enriched DNA fragments confirmed theftsZpromoter as in vivo binding site of FtsR and revealed additional potential target genes and a DNA-binding motif. Analysis of strains expressingftsZunder control of the gluconate-induciblegntKpromoter revealed that the phenotype of the ΔftsRmutant is not solely caused by reducedftsZexpression, but involves further targets.ConclusionsIn this study, we identified and characterized FtsR as the first transcriptional regulator of FtsZ described forC. glutamicum. Both the absence and the overproduction of FtsR had severe effects on growth and cell morphology, underlining the importance of this regulatory protein. FtsR and its DNA-binding site in the promoter region offtsZare highly conserved inActinobacteria, which suggests that this regulatory mechanism is also relevant for the control of cell division in relatedActinobacteria.
Comprehensive analysis of peroxiredoxins expression profiles and prognostic values in breast cancer
Authors: Mei Jie , Hao Leiyu , Liu Xiaorui , Sun Guangshun , Xu Rui , Wang Huiyu , Liu Chaoying 
Published: August 2019

Abstract
Background
The peroxiredoxins (PRDXs) gene family has been demonstrated to participate in carcinogenesis and development of numerous cancers and the prognostic values in several cancers have been evaluated already. Purpose of our research is to explore the expression profiles and prognostic values of PRDXs in breast cancer (BrCa).

Methods
The transcriptional levels of PDRX family members in primary BrCa tissues and their association with intrinsic subclasses were analyzed using UALCAN database. Then, the genetic alterations of PDRXs were examined by cBioPortal database. Moreover, the prognostic values of PRDXs in BrCa patients were investigated via the Kaplan-Meier plotter.

Results
The transcriptional levels of most PRDXs family members in BrCa tissues were significantly elevated compared with normal breast tissues. Meanwhile, dysregulated PRDXs expression was associated with intrinsic subclasses of BrCa. Besides, copy number alterations (CNA) of PRDXs positively regulated their mRNA expressions. Furthermore, high mRNA expression of PRDX4/6 was significantly associated with poor overall survival (OS) in BrCa patients, while high mRNA expression of PRDX3 was notably related to favorable OS. Simultaneously, high mRNA expression of PRDX1/2/4/5/6 was significantly associated with shorter relapse-free survival (RFS) in BrCa patients, while high mRNA expression of PRDX3 was notably related to favorable RFS. In addition, the prognostic value of PRDXs in the different clinicopathological features based on intrinsic subclasses and chemotherapeutic treatment of BrCa patients was further assessed in the KM plotter database.

Conclusion
Our findings systematically elucidate the expression profiles and distinct prognostic values of PRDXs in BrCa, which might provide novel therapeutic targets and potential prognostic biomarkers for BrCa patients.
Acute Exercise Effects Predict Training Change in Cognition and Connectivity
Authors: VOSS MICHELLE W. , WENG TIMOTHY B. , NARAYANA-KUMANAN KRITHIKA , COLE RACHEL C. , WHARFF CONNER , REIST LAUREN , DUBOSE LYNDSEY , SIGURDSSON GARDAR , MILLS JAMES A. , LONG JEFFREY D. , MAGNOTTA VINCENT A. , PIERCE GARY L. 
Published: August 2019

ABSTRACT

Purpose
Previous studies report memory and functional connectivity of memory systems improve acutely after a single aerobic exercise session or with training, suggesting that the acute effects of aerobic exercise may reflect initial changes that adapt over time. In this trial, for the first time, we test the proof-of-concept of whether the acute and training effects of aerobic exercise on working memory and brain network connectivity are related in the same participants.

Methods
Cognitively normal older participants (N = 34) were enrolled in a randomized clinical trial (NCT02453178). Participants completed fMRI resting state and a face working memory N-back task acutely after light- and moderate-intensity exercises and after a 12-wk aerobic training intervention.

Results
Functional connectivity did not change more after moderate-intensity training compared with light-intensity training. However, both training groups showed similar changes in cardiorespiratory fitness (CRF) (maximal exercise oxygen uptake, V˙O2peak), limiting group-level comparisons. Acute effects of moderate-intensity aerobic exercise on connections primarily in the default network predicted training enhancements in the same connections. Working memory also improved acutely, especially after moderate-intensity, and greater acute improvements predicted greater working memory improvement with training. Exercise effects on functional connectivity of right lateralized frontoparietal connections were related to both acute and training gains in working memory.

Conclusions
Our data support the concept of acute aerobic exercise effects on functional brain systems and performance as an activity-evoked biomarker for exercise training benefits in the same outcomes. These findings may lead to new insights and methods for improving memory outcomes with aerobic exercise training.
Comparison of efficacy between internal fixation of minimally invasive elastic stable intramedullary nail and plate in the treatment of pediatric femoral shaft fracture
Authors: Wang Wenxia , Zheng Xiaoyong , Sun Zuoyong 
Published: August 2019

Objective: To compare and analyze the clinical effects of internal fixation of minimally invasive elastic stable intramedullary nail and plate in the treatment of pediatric femoral shaft fracture.
Methods: A total of 120 children with femoral shaft fractures who were admitted to our hospital from December 2016 to April 2018 were enrolled. The children were divided into an observation group and a control group by random number table, with 60 children in each group. The children in the observation group underwent internal fixation of minimally invasive elastic stable intramedullary nail, while those in the control group underwent open reduction based on internal fixation of plate. The surgical status and postoperative complications of the two groups were observed and compared, and Kolmert knee function scoring criteria were used for assessing the surgical effects of children.
Results: The operation duration, intraoperative blood loss, hospitalization duration, fracture healing time and time of off-bed loaded activity of the observation group were significantly shorter than those of the control group, and the differences were statistically significant (P<0.05). The excellent and good rate of fracture healing in the observation group was 100%, which was higher than that of the control group, 83.33%, and the difference was statistically significant (P<0.05). The total incidence rate of complications in the observation group was 8.33%, which was lower than that of the control group, 10.00%, but the difference was not statistically significant (P>0.05).
Conclusion: Pediatric femoral shaft fractures can be treated with internal fixation of minimally invasive elastic intramedullary nail, and it has advantages of significant curative effect, small trauma and fast postoperative recovery, which is conducive to fracture healing and worth promoting.
doi: https://doi.org/10.12669/pjms.35.5.513
How to cite this:Wang W, Zheng X, Sun Z. Comparison of efficacy between internal fixation of minimally invasive elastic stable intramedullary nail and plate in the treatment of pediatric femoral shaft fracture. Pak J Med Sci. 2019;35(5):1417-1421. doi: https://doi.org/10.12669/pjms.35.5.513
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Etiological factors in young patients with Retinal Vein Occlusion
Authors: Nalcaci Serhad , Degirmenci Cumali , Akkin Cezmi , Mentes Jale 
Published: August 2019

Objective: To present the etiological factors of patients with Retinal Vein Occlusion (RVO) under the age of 50 years.
Methods: The study was conducted at Ege University Medicine Faculty Department of Ophthalmology. The clinical records of patients with RVO under the age of 50 seen between January 2014 and March 2018 were analyzed retrospectively. Forty patients comprised the study. Detailed ophthalmologic examination was performed. Past medical history, drug use, thrombophilic features, hyperviscosity syndromes and pathologies that may cause vasculitis were noted.
Results: Forty patients, 22 (55%) male and 18 (45%) female, were included. Mean age was 41.6 ± 10.01 years. Mean intraocular pressure and best-corrected visual acuity were 16.8 ± 5.47mmHg and 0.76 ± 0.64 logMAR, respectively. Hyperhomocystenemia (15 patients, 37.5%), Behçet’s disease (three patients, 7.5%), diabetes and/or hypertension (16 patients, 40%), methylenetetrahydrofolate reductase gene mutation (11 patients, 27.5%), prothrombin gene mutation (four patients, 10%) and factor V Leiden mutation (five patients, 12.5%) were present among the patients as etiological factor. Multiple etiological factors were detected in 11 (27.5%) patients. Factor V Leiden mutation and methylenetetrahydrofolate reductase gene mutation were detected in one patient (2.5%) with Behçet’s disease. Four patients with diabetes and/or hypertension also had hyperhomocystenemia and one of them had additionally prothrombin gene mutation. Two patients with methylenetetrahydrofolate reductase gene mutation also had a factor V Leiden mutation and one of them had additionally a prothrombin gene mutation. Three patients with methylenetetrahydrofolate reductase gene mutation also had hyperhomocystenemia and one patient with prothrombin gene mutation also had methylenetetrahydrofolate reductase gene mutation.
Conclusions: Etiological factors that might result in RVO in young individuals should be investigated in detail. Targeted therapies may help to prevent development of new RVOs and potential vascular problems in other organs.
doi: https://doi.org/10.12669/pjms.35.5.546
How to cite this:Nalcaci S, Degirmenci C, Akkin C, Mentes J. Etiological factors in young patients with Retinal Vein Occlusion. Pak J Med Sci. 2019;35(5):1397-1401. doi: https://doi.org/10.12669/pjms.35.5.546
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A New Index of Housing Sentiment
Authors: Bork Lasse , Møller Stig V. , Pedersen Thomas Q. 
Published: August 2019

We propose a new measure for housing sentiment and show that it accurately tracks expectations of future house price growth rates. We construct the housing sentiment index using partial least squares on household survey responses to questions about buying conditions for houses. We find that housing sentiment explains a large share of the time variation in house prices during both boom and bust cycles, and it strongly outperforms several macroeconomic variables typically used to forecast house prices. This paper was accepted by Tyler Shumway, finance.
Transformational leadership and innovation adoption: Is there a moderation role of personal initiative and job control?
Authors: Zappalà Salvatore , Toscano Ferdinando 
Published: August 2019

Hospital managers and chief physicians, but also doctors and nurses, in an effort to face constant changes, are involved in innovation. This study examines if transformational leadership style is related to adoption of employees’ suggestions, and if personal initiative and job control moderate this relationship. Nurses, doctors, and auxiliary and technical collaborators (n = 137), of an Italian public hospital, participated in this study. Results show that transformational leadership was correlated to innovation adoption but, when examined moderators were included in the analysis, the relation was no more significant. Personal initiative and job control did not moderate the relationship between transformational leadership and innovation adoption but they do have a significant direct effect on innovation adoption. Findings suggest that innovation in hospitals is more related to personal variables, like personal initiative and job control, rather than to transformational leadership.
La vérité est ailleurs. Complots et sorcellerie - J-P. Dozon, 2017
Authors: Sambieni N’koué Emmanuel 
Published: August 2019

Recensé : Jean-Pierre Dozon, La vérité est ailleurs. Complots et sorcellerie, Paris, Maison des Sciences de l’Homme, 2017 (« Interventions »), 87 p.
O JOGO DE ESPERANÇA E DESESPERO EM A MORATÓRIA, DE JORGE ANDRADE.
Authors: Monte Carlos Eduardo 
Published: August 2019

O presente trabalho pretende analisar a importância da obra do dramaturgo paulista Jorge Andrade (1922-1984), A moratória, no panorama do teatro nacional, procurando evidenciar qual a importância da mesma para a construção de nossa identidade, a partir de uma escrita que conjuga aspectos rurais e econômicos, e que traz como principal aspecto o plano social de conversão ideológica que se verifica a partir de 1930, como analisa Antonio Candido, em seu texto Literatura e desenvolvimento. O pano de fundo de A moratória fixa-se em dois planos temporais, 1929 e 1932, e seus personagens estão perdidos nessa conversão temporal e existencial, capaz de pôr em xeque valores sedimentados, em detrimento da crua realidade que arruína a aristocracia paulistana dona dos cafezais no interior do estado. Comparado em parte com a dramaturgia de Anton Tchekhov, sobretudo com O jardim das cerejeiras, A moratória reúne elementos que dão sólidos contornos a um tipo de drama capaz de incorporar com especificidade as fontes rurais raramente trabalhadas em nossa literatura, ligando-se a produção crítica que, a partir de 1950, abandona de vez o ideal do país novo.Palavras-chave: Teatro brasileiro; Jorge Andrade; A moratória; Identidade nacional.
SOBRE COMO MERGULHAR E FICAR DE CABEÇA ENXUTA: A REPRESENTAÇÃO DO ESTRANGEIRO EM CONTOS GAUCHESCOS E LENDAS DO SUL
Authors: Arendt Joao Claudio 
Published: August 2019

Este artigo objetiva discutir a representação tanto do brasileiro (especialmente o carioca, o paulista e o baiano) quanto do estrangeiro (o açoriano, o português, o inglês, o alemão e, em especial, o castelhano e o espanhol) nas obras Contos gauchescos e Lendas do Sul, de João Simões Lopes Neto. A perspectiva assumida pelo autor, Simões Lopes, e seu narrador, Blau Nunes, é de critica a qualquer influência cultural oriunda do centro e do nordeste do país, e de franca oposição ao que provém do exterior, especialmente da Europa e da América hispânica. Para embasar a análise, recorre-se à historiografia, à crítica literária e a estudos sobre identidade. Palavras-chave: Simões Lopes Neto; representação; identidade; estrangeiros.
E-PÍSTOLAS: AS VIDEOPOESIAS DE MATILDE CAMPILHO E A RELAÇÃO LITERÁRIA ENTRE BRASIL E PORTUGAL
Authors: Kickhöfel Tiago Radatz , Fonseca Claudia Lorena Vouto da 
Published: August 2019

Este texto apresenta um percurso de articulações teóricas e críticas possíveis para a leitura de um projeto literário hipermidiático e do seu reflexo em um sistema cultural mais amplo. Trata-se do projeto videopoético da escritora Matilde Campilho e seus desdobramentos na perplexa relação literária entre Brasil e Portugal. Eis que se divide em duas partes, na primeira justifica sua posição crítica e localiza a poeta e sua produção no estudo, bem como verifica motivações históricas motrizes de tais ruídos no diálogo literário luso-brasileiro; a segunda parte é dedicada à análise formal da videopoesia e suas imbricações no corpus poético selecionado, o videopoema Fevereiro. O objetivo desta análise é, portanto, entender essa problemática cultural e o modo pelo qual a autora a contornou, isto é, a dupla perspectiva de alteridade que cumpre em seu projeto-processo literário hipermídia.Palavras-chave: identidade; hibridação cultural; videopoesia.