bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ligand‐Responsive Artificial Protein–Protein Communication for Field‐Deployable Cell‐Free Biosensing
Authors: Wang Ke , Liu Siqian , Zhou Shuqi , Qileng Aori , Wang Dingyi , Liu Yingju , Chen Chunlai , Lei Chunyang , Nie Zhou 
Published: November 2024

AbstractNatural protein–protein communications, such as those between transcription factors (TFs) and RNA polymerases/ribosomes, underpin cell‐free biosensing systems operating on the transcription/translation (TXTL) paradigm. However, their deployment in field analysis is hampered by the delayed response (hour‐level) and the complex composition of in vitro TXTL systems. For this purpose, we present a de novo‐designed ligand‐responsive artificial protein–protein communication (LIRAC) by redefining the connection between TFs and non‐interacting CRISPR/Cas enzymes. By rationally designing a chimeric DNA adaptor and precisely regulating its binding affinities to both proteins, LIRAC immediately transduces target‐induced TF allostery into rapid CRISPR/Cas enzyme activation within a homogeneous system. Consequently, LIRAC obviates the need for RNA/protein biosynthesis inherent to conventional TXTL‐based cell‐free systems, substantially reducing reaction complexity and time (from hours to 10 minutes) with improved sensitivity and tunable dynamic range. Moreover, LIRAC exhibits excellent versatility and programmability for rapidly and sensitively detecting diverse contaminants, including antibiotics, heavy metal ions, and preservatives. It also enables the creation of a multi‐protein communication‐based tristate logic for the intelligent detection of multiple contaminants. Integrated with portable devices, LIRAC has been proven effective in the field analysis of environmental samples and personal care products, showcasing its potential for environmental and health monitoring.
Precise Photochemical Post‐Processing of Molecular Crystals
Authors: Qi Jianqun , Lan Linfeng , Chen Quanliang , Li Liang , Naumov Panče , Zhang Hongyu 
Published: November 2024

AbstractMolecular crystals carry a great potential as new soft smart materials, with a plethora of recent examples overcoming the major obstacle of mechanical flexibility, and this research direction holds enormous potential to revolutionize optics, electronics, medicine, and space exploration. However, shaping organic crystals into desired shapes and sizes remains a major practical challenge due to the lack of control over the crystallization process, and the difficulties in mechanical post‐processing without introduction of defects that are usually imparted by their soft nature. Here we present an innovative approach that employs photochemical processing for precise and nondestructive cutting of a molecular crystal. Our proposed method uses light to post‐process crystals of the desired size and shape, similar to using light to cut other materials. This reaction induces strain, ensuring sharp cleavage without the need for melting or other processes. We further demonstrate the potential of this approach by producing crystals of arbitrary size, which can be used as controllable optical waveguides. Among other potential applications, this method can be used to prepare dynamic crystals, particularly those with aspect ratios crucial for mechanical deformation, such as flexible electronics, soft robotics, and sensing.
Unconventional Near‐Equilibrium Nucleation of Graphene on Si‐Terminated SiC(0001) Surface
Authors: Huang Haojie , Ren Zebin , Xue Xiao , Guo Haoyuancheng , Chen Jianyi , Guo Yunlong , Liu Yunqi , Dong Jichen 
Published: November 2024

AbstractThe transfer‐free character of graphene growth on Silicon Carbide (SiC) makes it compatible with state‐of‐the‐art Si semiconductor technologies for directly fabricating high‐end electronics. Although significant progress has been achieved in epitaxial growth of graphene on SiC recently, the underlying nucleation mechanism remains elusive. Here, we present a theoretical study to elucidate graphene near‐equilibrium nucleation on Si‐terminated hexagonal‐SiC(0001) surface. It is found that the ultra‐large lattice mismatch between SiC(0001) surface and graphene and the highly localized electron distribution on SiC(0001) surface lead to a distinctive nucleation process: (i) Most of the magic carbon clusters on SiC(0001) show only C1 symmetry and are mainly composed of pentagonal rings; (ii) Two possible nucleation pathways are revealed, i.e., longitudinal and circular modes; (iii) Carbon clusters are more stable on flat terraces than near atomic step edges. Based on above findings, a graphene nucleation diagram on SiC(0001) is established and experimentally observed contradictories for graphene growth on SiC(0001) are answered. Our in‐depth understanding on graphene nucleation on SiC(0001) extends nucleation mechanisms of 2D crystals and will benefit high‐quality graphene growth on SiC(0001).
Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy
Authors: Hou Guanghui , Chen Youdong , Lei Huali , Lu Shunyi , Cheng Liang 
Published: November 2024

AbstractMalignant tumors pose a significant threat to global public health. Promoting programmed cell death in cancer cells has become a critical strategy for cancer treatment. PANoptosis, a newly discovered form of regulated cell death, integrates key molecular components of pyroptosis, apoptosis, and necroptosis, activating these three death pathways simultaneously to achieve synergistic multi‐mechanistic killing. PANoptosis significantly inhibits cancer cell growth and resistance and activates strong anti‐tumor immune response, making tumor‐specific induction of PANoptosis a potential cancer therapeutic strategy. Currently, cancer treatment research related to PANoptosis is focused mainly on the development of small molecules and cytokines. However, these approaches still face limitations in terms of metabolic stability and tumor specificity. The unique physicochemical properties and biological activities of nanomaterials hold significant promise for optimizing PANoptosis induction strategies. This review summarizes the concept and mechanisms of PANoptosis, highlights the latest applications of nanoagents in PANoptosis‐based anti‐cancer therapy, and discusses the challenges and future directions for clinical translation. It is hoped that this review will inspire further exploration and development of PANoptosis‐based cancer treatments, providing new perspectives for researchers in the field.
Confinement Microenvironment Regulation of Carbon Dots in Zeolite for Multi‐Mode Time‐Dependent Phosphorescence Color Evolution
Authors: Zong Siyu , Wang Bolun , Zhang Jiani , Yu Xiaowei , Zhou Yida , Chen Yuze , Zhang Tianjun , Li Jiyang 
Published: November 2024

AbstractMatrix immobilization has been proven to be a favored method for enhancing the phosphorescence of carbon dots (CDs), however, it remains a significant challenge to realize time‐dependent phosphorescence colors (TDPC) by embedding CDs with single emission center. In this study, we present a novel matrix‐controlling strategy to regulate the microenvironment of CDs by doping limited Mn2+ in zeolite. The surrounding environment influences the surface state of the CDs, leading to the formation of different excitons. At low temperatures, Mn‐coordinated CDs (C‐CDs) show fast‐decaying green phosphorescence, while non‐coordinated CDs (NC‐CDs) exhibit inherent slow‐decaying blue phosphorescence. Notably, the energy transfer occurs between NC‐CDs and Mn2+ to produce an ultrafast‐decaying red phosphorescence, with the intensity of the red component increasing as the temperature rises. The interplay of these luminescent centers with distinct decay rates activates fascinating multi‐mode TDPC behavior as the temperature changes, resulting in dynamic afterglow evolutions from red to green at 298 K, orange to green at 273 K, and green to cyan to blue at 77 K. Leveraging the diverse luminescence of CDs@MnAPO‐5, a multi‐dimensional dynamic afterglow color pattern was developed for advanced anti‐counterfeiting applications.
Tailored Metal–Organic Framework‐Based Nanozymes for Enhanced Enzyme‐Like Catalysis
Authors: Yu Zhichao , Xu Zhenjin , Zeng Ruijin , Xu Man , Zou Minglang , Huang Da , Weng Zuquan , Tang Dianping 
Published: November 2024

AbstractThe global crisis of bacterial infections is exacerbated by the escalating threat of microbial antibiotic resistance. Nanozymes promise to provide ingenious solutions. Here, we reported a homogeneous catalytic structure of Pt nanoclusters with finely tuned metal–organic framework (ZIF‐8) channel structures for the treatment of infected wounds. Catalytic site normalization showed that the active site of the Pt aggregates structure with fine‐tuned pore modifications structure had a catalytic capacity of 14.903×105 min−1, which was 18.7 times higher than that of the Pt particles in monodisperse state in ZIF‐8 (0.793×105 min−1). In situ tests revealed that the change from homocleavage to heterocleavage of hydrogen peroxide at the interface of the nanozyme was one of the key reasons for the improvement of nanozyme activity. Density‐functional theory and kinetic simulations of the reaction interface jointly determine the role of the catalytic center and the substrate channel together. Metabolomics analysis showed that the developed nanozyme, working in conjunction with reactive oxygen species, could effectively block energy metabolic pathways within bacteria, leading to spontaneous apoptosis and bacterial rupture. This pioneering study elucidates new ideas for the regulation of artificial enzyme activity and provides new perspectives for the development of efficient antibiotic substitutes.
Arene Ring Expansion by Ruthenium η6‐Arene Complexes
Authors: Whitehurst William G. , Schulte Tim , Wang Zikuan , Waldbach Felix , Ritter Tobias 
Published: November 2024

AbstractTransition metal π‐arene complexes enable the dearomatization of benzene rings to access diversified unsaturated carbocycles through multistep synthetic procedures involving sequential addition of nucleophiles and electrophiles. This work details a single‐step dearomatization process by reaction of Ru(η6‐arene) complexes with enolates derived from α‐halo or α‐(tosyloxy)esters to directly transform π‐coordinated arenes to ring‐expanded cycloheptatrienes.
Inverse Vulcanization of Aziridines: Enhancing Polysulfides for Superior Mechanical Strength and Adhesive Performance
Authors: Fan Jieai , Ju Changzheng , Fan Songjie , Li Xia , Zhang Zhen , Hadjichristidis Nikos 
Published: November 2024

AbstractThis study introduces a novel approach to inverse vulcanization by utilizing a commercially available triaziridine crosslinker as an alternative to conventional olefin‐based crosslinkers. The model reactions reveal a self‐catalyzed ring‐opening of “unactivated” aziridine with elemental sulfur, forming oligosulfide‐functionalized diamines. The triaziridine‐derived polysulfides exhibit impressive mechanical properties, achieving a maximum stress of ~8.3 MPa and an elongation at break of ~107 %. The incorporation of silicon dioxide (20 wt %) enhances the composite's rigidity, yielding a Young's modulus of ~0.94 GPa. Furthermore, these polysulfides display excellent adhesion strength on various substrates, such as aluminum (~7.0 MPa), walnut (~9.6 MPa), and steel (~11.0 MPa), with substantial retention of adhesion strength (~3.3 MPa on steel) at −196 °C. The straightforward synthetic process, combined with the accessibility of the triaziridine crosslinker, emphasizes the potential for further innovations in sulfur polymer chemistry.
Rapid, Non‐Invasive, Accurate Diagnosis and Efficient Clearance of Metastatic Lymph Nodes
Authors: Ling Sisi , Yang Hongchao , Wu Feng , Yang Xiaohu , Li Tuanwei , Zhang Yejun , Jiang Jiang , Li Chunyan , Wang Qiangbin 
Published: November 2024

AbstractSentinel lymph node (SLN) biopsy is currently the standard procedure for clinical cancer diagnosis and treatment, but still faces the risks of false negatives and tumor metastasis, as well as time‐consuming pathological evaluation procedure. Herein, we proposed a near‐infrared‐II (NIR‐II, 1000–1700 nm) theranostic nanosystem (FLAGC) for rapid, non‐invasive, accurate diagnosis and efficient clearance of metastatic lymph nodes in breast cancer. Initialized by chlorin e6 (Ce6), a pH‐sensitive amphiphilic amino acid fluorenylmethoxycarbonyl‐L‐histidine (Fmoc‐His) was assembled with Gd3+, luminol, and AgAuSe quantum dots (AAS QDs) to form FLAGC. In FLAGC, luminol and AAS QDs form a NIR‐II chemical resonance energy transfer (CRET) system (Luminol‐AAS); Ce6 initiates the assembly and also serves as a photosensitizer. Upon subcutaneous injection, FLAGC is easily drained into SLNs, achieving their precise localization. Subsequently, the acidity of tumor microenvironment triggers the rapid disassembly of FLAGC, exposing Luminol‐AAS. myeloperoxidase (MPO) secreted by tumor‐associated macrophages and neutrophils in SLNs mediates the oxidation of luminol, lighting up AAS QDs through the CRET process for precise diagnosis of metastatic lymph nodes. Moreover, highly efficient clearance of positive lymph nodes is achieved through Ce6‐mediated photodynamic therapy. Our strategy provides a new paradigm for identifying and eliminating clinically metastatic lymph nodes.
Adamantane‐Type Nitridophosphate Phosphors AExLi10−2xP4N10 : Eu2+ via Medium‐Pressure Ion‐Exchange Reactions
Authors: Pritzl Reinhard M. , Buda Amalina T. , Witthaut Kristian , Schmidt Peter J. , Schnick Wolfgang 
Published: November 2024

AbstractNitridophosphates have emerged as promising host compounds in the field of solid‐state lighting. Their industrial relevance has increased significantly, mainly due to recent advances in synthetic approaches under medium‐pressure (MP) conditions, including ammonothermal synthesis and hot isostatic pressing (HIP). In this study, we report on the synthesis and characterization of the quaternary representatives CaxLi10−2xP4N10 (x=2, 2.7, 4) and Sr3Li4P4N10, prepared via a simplified ion exchange reaction under MP conditions, starting from the nitridophosphate‐based lithium ion conductor Li10P4N10. The synthesis route allowed for the preservation of the anionic [P4N10]10− structural motif of the starting material, while simultaneously introducing potential doping sites for Eu2+ by incorporating divalent alkaline earth cations (Ca2+/Sr2+). Upon excitation of Eu2+ doped samples with blue light, strong luminescence due to parity‐allowed 4f6(7F)5d1→4f7(8S7/2) transition can be observed in the red (Ca2Li6P4N10 : Eu2+: λmax=626 nm), yellow/orange (Ca2.7Li4.6P4N10 : Eu2+: λmax1=506 nm, λmax2=592 nm and Sr3Li4P4N10 : Eu2+: λmax=596 nm) and green (Ca4Li2P4N10 : Eu2+: λmax=546 nm) spectral regions of the visible light. The compounds presented, together with the simplified synthetic approach, demonstrate the significant potential of ion exchange on Li ion conductors for the development of novel nitridophosphates in the future.
A Pair of Deep Red Phosphorescent Responsive Emissive Cyclometalated Iridium (III) Complexes as Carbonic Anhydrase Inhibitor and Effective Theranostic Photosensitizer
Authors: Yang Jiayan , Wang Ting , Wang Pengchao , Gao Chuanzhu , Yang Jing 
Published: November 2024

ABSTRACTHerein, two deep red phosphorescent responsive emissive cyclometalated iridium (III) complexes with CAIX inhibition moiety was designed and synthesized; they can penetrate into living cells quickly and mainly located in the lysosome. They showed a strong binding affinity towards CAIX in vitro and effectively reduced cellular expression of CAIX. Moreover, the tethered CAIX‐inhibition moiety of benzene sulfonamide can decrease the inherent cytotoxicity of Ir(III) complex towards normal cells and improve killing selectivity towards cancer cells in dark; Ir3 and Ir4 exhibit approximately five to eight times higher killing selectivity than that of cisplatin; they exhibit satisfied photodynamic therapy effect under irradiation of 425 nm, ultimately resulting in apoptosis of cancer cell, which is accompanied with weakening of extracellular acidification, increased inhibition of cellular CAIX expression, significant loss of mitochondrial membrane potential, and elevated level of reactive oxygen. Herein, our work may demonstrate that combination of inhibition CAIX and metal photosensitizer may provide a promising strategy for constructing a novel theranostic platform.
Antioxidants Recognition Colorimetric Sensor Array Based on Multicolor System
Authors: Huang Wei , Wen Hongkuan , Li Yao , Wang Wenhua , Long Dengying 
Published: November 2024

ABSTRACTA colorimetric sensor array with three identification signals has been developed to visually recognize five antioxidants based on CuFe Prussian blue analogs nanocubes (CuFe PBA NCs) and 3,3′,5,5′‐tetramethylbenzidine (TMB). The CuFe PBA NCs can oxidize TMB to produce three ultraviolet–visible (UV–Vis) absorption peaks at different wavelengths (370, 450, and 650 nm). Depending on the different reduction capacity of dopamine, cysteine, ascorbic acid, glutathione, and melatonin, the redox process can be inhibited to varying degrees, resulting in different changes in the signal generation of three identification elements. And in the presence of different antioxidants, the color of the solution also changes in different degrees. Five antioxidants (20 μM) can be identified by this colorimetric sensor array, and the identification accuracy was 100% for 40 unknown antioxidants. In addition, these antioxidants can also be quantified based on the regression equation between the concentration of the antioxidants and the absorbance change. The correlation coefficient is greater than 0.990, and the detection limit is less than 3.5 μM.
A Systematic Study on the Polymerization Processes and Resulting Polymer Properties of Bioinspired Sesamol and Diamine‐Based Benzoxazines
Authors: Haubold Thorben S. , Abels Gideon , Koschek Katharina 
Published: November 2024

ABSTRACTBenzoxazine monomers based on sesamol and aliphatic diamines with a systematic variation of chain lengths were synthesized to study the influence of the diamine chain lengths on thermal and thermo‐mechanical properties. Differential scanning calorimetry analysis revealed an even‐odd effect as the melting point for monomers with an odd chain length was at least 35°C lower compared to their even counterparts. In addition, longer diamine chain lengths increased the beginning of the polymerization from 187°C for diaminoethane (DAE) up to 218°C for diaminohexane (DAH). Rheological analysis revealed a short time frame between the melting and polymerization for monomers based on diaminoethane, ‐propane or ‐butane preventing a polymerization. Polymerization was successful for sesamol benzoxazine with diaminopentane (S‐DAPe) and ‐hexane (S‐DAH) resulting polymers with high glass transition temperatures of up to 228°C for poly(S‐DAPe) and 231°C for poly(S‐DAH), respectively. Remarkably, it was found that S‐DAH could also be polymerized at a lower temperature of 155°C yielding a T
g of 175°C. Furthermore, MCC results showed that peak heat release rate and total heat release of the diamine based polybenzoxazines decrease with decreasing chain length. In comparison to other sesamol based benzoxazines the presence of diamine linkers result in bisbenzoxazines with higher T
g.
Substrate‐Dependent Stereoselective Synthesis of Pyrrolo[3,4‐b]Pyridin‐5‐Ones and Pyridyl Isoindoline‐1‐Ones Using Bis(benzotriazol‐1‐yl) Ligand
Authors: Yadav Mangal S. , Jaiswal Manoj K. , Kumar Sunil , Singh Sumit K. , Garai Somenath , Tiwari Vinod K. 
Published: November 2024

AbstractThe documented work highlighted the synthesis of bis(benzotriazol‐1‐yl) methane derivatives using silicomolybdic acid (SMA) and successfully implemented in the stereoselective synthesis of diverse pyrrolo[3,4‐b]pyridin‐5‐one and pyridyl isoindolinones derivatives in one‐pot. The pyridinamide precursor with diverse alkynes furnished Z‐selectivity of pyrrolo[3,4‐b]pyridin‐5‐one across exocyclic C=C bond while the various benzamides on treating with 2‐ethynyl pyridine afforded (E)‐pyridylisoindoline‐1‐ones as a major isomer. The single‐crystal X‐ray diffraction provides strong evidence in favor of the existence and orientation of developed compounds. The broad substrate scope, easy accessibility of substrates, high stereoselectivity, scale‐up synthesis, and crystal evidence demonstrate the merits of the current decorum.
Narrative abilities of autistic and non‐autistic adolescents: The role of mentalising and executive function
Authors: Harvey Anna , Spicer‐Cain Helen , Botting Nicola , Henry Lucy 
Published: November 2024

AbstractSpoken narrative skills are important for adolescents in their everyday lives. Previous research suggests that producing well‐structured and coherent narratives may be challenging for autistic young people. Mentalising, also known as “advanced Theory of Mind” (ToM) and “Executive Function” (EF) are two cognitive abilities frequently explored in relation to autism, both of which may be implicated in narrative ability. The present study investigated these relationships in a group of autistic adolescents (N = 44) aged 11–15 years and a comparable non‐autistic group (N = 54) that did not significantly differ on age, sex, nonverbal cognitive ability, or receptive/expressive language skills. Participants were assessed on a video‐based spoken narrative task, scored for both overall structure (“story grammar”) and narrative coherence. A battery of tasks measuring mentalising and EF (working memory, inhibition, shifting, generativity) was also administered. Relationships between scores on cognitive measures and narrative performance were investigated using hierarchical linear regression analyses. Mentalising scores were found to significantly predict narrative performance across all outcome measures and were a stronger predictor than diagnostic group. Diagnostic group predicted narrative structure (“story grammar”) scores but not coherence scores. EF scores were not predictive of narrative ability in this sample. Mentalising skills appear to play an important role for both autistic and non‐autistic adolescents in the generation of narrative structure and coherence within spoken accounts.
Enantioselective Membranes for Pharmaceutical Applications: A Comprehensive Review
Authors: Gogoi Monti , Goswami Rajiv , Borah Akhil Ranjan , Phukan Lachit , Hazarika Swapnali 
Published: November 2024

ABSTRACTIn the past decade, significant advances have been made in the field of chiral separation, which is crucial for biological and pharmaceutical applications. Enantioselective membranes have emerged as a promising platform for efficient chiral separation due to their unique properties such as large surface area, tunable pore size, and high selectivity. These membranes are particularly effective in separating enantiomers because of their ability to facilitate selective interactions between the membrane material and chiral molecules. This article provides a comprehensive review of the recent progress in enantioselective membranes for chiral separation. Key topics discussed include various membrane fabrication methods, functionalization approaches, and the characterization of membrane properties, specifically in the context of applications like drug delivery, biomolecule separation, and pharmaceutical analysis. Furthermore, the review addresses the current challenges, potential solutions, and future prospects in this rapidly evolving field, highlighting the direction for upcoming research.