bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viral Hormones: Expanding Dimensions in Endocrinology
Authors: Huang Qian , Kahn C Ronald , Altindis Emrah 
Published: July 2019

AbstractViruses have developed different mechanisms to manipulate their hosts, including the process of viral mimicry in which viruses express important host proteins. Until recently, examples of viral mimicry were limited to mimics of growth factors and immunomodulatory proteins. Using a comprehensive bioinformatics approach, we have shown that viruses possess the DNA/RNA with potential to encode 16 different peptides with high sequence similarity to human peptide hormones and metabolically important regulatory proteins. We have characterized one of these families, the viral insulin/IGF-1–like peptides (VILPs), which we identified in four members of the Iridoviridae family. VILPs can bind to human insulin and IGF-1 receptors and stimulate classic postreceptor signaling pathways. Moreover, VILPs can stimulate glucose uptake in vitro and in vivo and stimulate DNA synthesis. DNA sequences of some VILP-carrying viruses have been identified in the human enteric virome. In addition to VILPs, sequences with homology to 15 other peptide hormones or cytokines can be identified in viral DNA/RNA sequences, some with a very high identity to hormones. Recent data by others has identified a peptide that resembles and mimics α-melanocyte-stimulating hormone’s anti-inflammatory effects in in vitro and in vivo models. Taken together, these studies reveal novel mechanisms of viral and bacterial pathogenesis in which the microbe can directly target or mimic the host endocrine system. These findings also introduce the concept of a system of microbial hormones that provides new insights into the evolution of peptide hormones, as well as potential new roles of microbial hormones in health and disease.
Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism
Authors: Storbeck Karl-Heinz , Schiffer Lina , Baranowski Elizabeth S , Chortis Vasileios , Prete Alessandro , Barnard Lise , Gilligan Lorna C , Taylor Angela E , Idkowiak Jan , Arlt Wiebke , Shackleton Cedric H L 
Published: July 2019

AbstractSteroid biosynthesis and metabolism are reflected by the serum steroid metabolome and, in even more detail, by the 24-hour urine steroid metabolome, which can provide unique insights into alterations of steroid flow and output indicative of underlying conditions. Mass spectrometry–based steroid metabolome profiling has allowed for the identification of unique multisteroid signatures associated with disorders of steroid biosynthesis and metabolism that can be used for personalized approaches to diagnosis, differential diagnosis, and prognostic prediction. Additionally, steroid metabolome analysis has been used successfully as a discovery tool, for the identification of novel steroidogenic disorders and pathways as well as revealing insights into the pathophysiology of adrenal disease. Increased availability and technological advances in mass spectrometry–based methodologies have refocused attention on steroid metabolome profiling and facilitated the development of high-throughput steroid profiling methods soon to reach clinical practice. Furthermore, steroid metabolomics, the combination of mass spectrometry–based steroid analysis with machine learning–based approaches, has facilitated the development of powerful customized diagnostic approaches. In this review, we provide a comprehensive up-to-date overview of the utility of steroid metabolome analysis for the diagnosis and management of inborn disorders of steroidogenesis and autonomous adrenal steroid excess in the context of adrenal tumors.
Genetic Evidence of the Association of DEAH-Box Helicase 37 Defects With 46,XY Gonadal Dysgenesis Spectrum
Authors: da Silva Thatiana Evilen , Gomes Nathalia Lisboa , Lerário Antonio Marcondes , Keegan Catherine Elizabeth , Nishi Mirian Yumi , Carvalho Filomena Marino , Vilain Eric , Barseghyan Hayk , Martinez-Aguayo Alejandro , Forclaz María Verónica , Papazian Regina , Pedroso de Paula Leila Cristina , Costa Eduardo Corrêa , Carvalho Luciani Renata , Jorge Alexander Augusto Lima , Elias Felipe Martins , Mitchell Rod , Costa Elaine Maria Frade , Mendonca Berenice Bilharinho , Domenice Sorahia 
Published: July 2019

AbstractContext46,XY Gonadal dysgenesis (GD) is a heterogeneous group of disorders with a wide phenotypic spectrum, including embryonic testicular regression syndrome (ETRS).ObjectiveTo report a gene for 46,XY GD etiology, especially for ETRS.DesignScreening of familial cases of 46,XY GD using whole-exome sequencing and sporadic cases by target gene-panel sequencing.SettingTertiary Referral Center for differences/disorders of sex development (DSD).Patients and InterventionsWe selected 87 patients with 46,XY DSD (17 familial cases from 8 unrelated families and 70 sporadic cases); 55 patients had GD (among them, 10 patients from 5 families and 8 sporadic cases had ETRS), and 32 patients had 46,XY DSD of unknown etiology.ResultsWe identified four heterozygous missense rare variants, classified as pathogenic or likely pathogenic in the Asp-Glu-Ala-His-box (DHX) helicase 37 (DHX37) gene in five families (n = 11 patients) and in six sporadic cases. Two variants were recurrent: p.Arg308Gln (in two families and in three sporadic cases) and p.Arg674Trp (in two families and in two sporadic cases). The variants were specifically associated with ETRS (7/14 index cases; 50%). The frequency of rare, predicted-to-be-deleterious DHX37 variants in this cohort (14%) is significantly higher than that observed in the Genome Aggregation Database (0.4%; P &lt; 0.001). Immunohistochemistry analysis in human testis showed that DHX37 is mainly expressed in germ cells at different stages of testis maturation, in Leydig cells, and rarely in Sertoli cells.ConclusionThis strong genetic evidence identifies DHX37 as a player in the complex cascade of male gonadal differentiation and maintenance.
Calendars in Knotted Cords: New Evidence on How Khipus Captured Time in Nineteenth-Century Cuzco and Beyond
Authors: de la Puente José Carlos 
Published: July 2019

AbstractDespite the critical advances toward khipu decipherment, the specific ways in which Andean khipu masters captured and organized the course of time in their cords, in the form of ages, dates, chronologies, and calendric intervals and cycles, remains obscure. This essay contributes to this central problem of knot making and reading traditions by enlisting the aid of an unlikely source: the memoirs of a mid-nineteenth-century gentleman who was given a striking account of how khipu masters in Cuzco’s countryside recorded specific events of a twelve-month calendar in their khipus and made accurate calculations based on them. The analysis and reconstruction of Cuzco’s calendar-demographic khipus is framed into the history of Catholic catechesis, which included early efforts at colonizing indigenous ways of thinking and experiencing time through tactile, visual, and sonic strategies. This process, rather than marginalizing knotted cords all together, as it is sometimes assumed, turned khipukamayuq into important, yet often overlooked agents for the gradual establishment of the Roman Catholic calendar in Andean rural parishes. Unraveling the basic principles for the accounting of time in these modern khipus by placing them in their historical context is a firm, and to our knowledge unprecedented, step toward future efforts at deciphering both quantitative and qualitative cords with a temporal component.
МЕТОДИКА ВОЕННО-ЭКОНОМИЧЕСКОГО ОБОСНОВАНИЯ ОБЕСПЕЧЕНИЯ ТЕХНОЛОГИЧЕСКОЙ НЕЗАВИСИМОСТИ РОССИЙСКОГО ОПК
Authors: Naruzhny Vyacheslav Evgenyevich , Kurbanov Artur Khusainovich , Plotnikov Vladimir Aleksandrovich 
Published: July 2019

В современных условиях большое значение имеет создание национальной технологической базы в интересах российского оборонно-промышленного комплекса. Создание такой базы может быть обеспечено путем реализации целевой промышленной политики. Выбор варианта такой политики осуществляется на основе оценки ожидаемого от ее реализации военно-экономического эффекта.Цель статьи: разработка методики оценки военно-экономического эффекта от мер по поддержке развития отечественного станкостроения.Методы: общенаучные методы анализа и синтеза, метод математического моделирования.Результаты: в статье разработаны методы оценки прямого и косвенного экономического эффекта от реализации промышленной политики по поддержке российского станкостроения в интересах ОПК, метод оценки военного эффекта, метод оценки интегрального военно-экономического эффекта.
An Assessment of Water and Sediment Quality of River in India with Special Reference to Pesticide Contamination, a Case Study
Authors: A.H Divya , A. Soloman P 
Published: July 2019

Drinking water quality has become a serious issue in many countries due to the scarcity of fresh water resources. Water quality monitoring is the first step for the management and conservation of aquatic system. The contamination of OrganoChlorine Pesticides (OCPs) is very harmful for the environment and human beings. The presence of OCPs in surface water and in the bottom sediment in the Chalakudy River was investigated to evaluate the pollution load and distribution level of OCP seasonally over a period of 3 years from January 2013 to December 2015. Surface water sample and bottom sediment were collected from nine different sites (upstream, midstream and downstream) and analyzed for their profile of important physicochemical parameters and for persistence of OCP. To know the present trends in the river clearly ,temporal distribution and spatial distribution of OCPs and other parameters are studied based on three season(winter, summer, and monsoon).Obtained trend in each year were compared through sampling and analysis.
Treatment of Pretreated Textile Wastewater Using Modified Mbbr
Authors: J.Sosamony K , A.Soloman P 
Published: July 2019

Currently, water pollution control is one of the major logical zones. The textile industry is a major pollution causing industry among the industrial pollutions. Treatment of textile effluent utilizing customary physical as well as chemical strategies is costly, produces enormous amounts of sludge and needs the expansion of lethal chemicals. BOD to COD proportion of textile effluent is low. Thus it is not appropriate to treat textile effluent by a solitary physicochemical or biological process. In this investigation, the textile effluent is dealt with utilizing Moving Bed Bio-film Reactor (MBBR) with the magnetic field after improving the biodegradability by the solar photo-Fenton process. The carriers in MBBR is inoculated with azoarcus bacteria isolated from textile sludge. The fundamental parameters as pH, carrier filling ratio and contact time were optimized utilizing Box Behnken factual design. The MBBR process has most extreme efficiency at pH 7, filling ratio of 62% and a contact time 2.4 days. In this optimum condition 68.9% BOD and 80% COD are expelled. At the point when the pretreated wastewater was dealt with MBBR reactor under the influence of magnetic field, the efficiency of the treatment is additionally expanded, so 87.4% COD expulsion and 87% BOD evacuation were accomplished at 12 mT attractive field power when exposure time was at 12 hrs.
Local Wisdom and National Integration in Indonesia: A Case Study of Inter-Religious Harmony amid Social and Political Upheaval in Bunga Bondar, South Tapanuli
Authors: Sinaga Rosmaida , Tanjung Flores , Nasution Yuri 
Published: July 2019

This study emphasizes on inter-religious affairs happened in Bunga Bondar, South Tapanuli began to experience turmoil when thenational movement era started in 1908 and itstillhappens to present-day. The Dutch colonial government advocated for inter-religiousharmony at a local level. The policy was pursued by the the Dutch colonial government out offear that the Indonesian people would developa sense of unity and fraternityamong them, thereby intensifying thespirit of nationalism. The Dutch government’s concern eventuallycame true when the power of the Christian wingof the national movement cooperated with itsIslamic counterpart. Along with the political upheavalsand social changes experienced by the Indonesian people, the harmony between religious groups in various regions was affected. Despite migration, changes of central and local leadership, and the flow of modernization that took place, the dynamics of inter-religious harmony of the 1930s are still present today.The tradition, the spirit of harmony, leadership models, and the application of local wisdom are all the key to the survival of inter-religious harmony in Bunga Bondar, South Tapanuli, as findings in research that can be used as a guide or model to build national integrity.
PEMBLOKIRAN BUKU TANAH YANG DILAKUKAN OLEH PIHAK PEMBELI BERDASARKAN AKTA PERJANJIAN PENGIKATAN JUAL BELI
Authors: Ibrahim Filzah Azizah 
Published: July 2019

Abstract Blocking of a book of certified land begins with a legal relationship between two or more parties involving the certificate as the object of the dispute. Losses experienced by one party in the process of buying and selling led to the application of blocking the book of land certificate to the office. The significance of this writing is to know and analyze the status of the Deed of Sale and Purchase Agreement in the process of blocking the land book by the buyer in the land office and the form of legal protection provided by the land office to the injured party due to buyer blocking based on the Deed of Sale and Purchase Agreement. The result of this research is the position of the sale and purchase binding agreement in the process of blocking the land book conducted by the buyer in the land office only as evidence of actual delivery and juridical delivery between the seller and buyer on the object of sale and purchase, not as an administrative requirement blocking at the land office. The Land Affairs Office provides legal protection by implementing the provisions of Article 125 and Article 126 of the Regulation of the Minister of Agrarian Affairs / Head of the National Land Agency Number 3 of 1997 by limiting the party who wishes to file a blocking request to the land office is a party with a strong legal basis to file the request for blocking in an effort defend that right so that it will not harm the other party. AbstrakPemblokiran buku tanah sertipikat diawali oleh suatu hubungan hukum antara dua pihak atau lebih yang melibatkan sertipikat sebagai obyek sengketa.Kerugian yang dialami oleh salah satu pihak dalam proses jual beli memunculkan adanya permohonan pemblokiran buku tanah sertipikat ke kantor. Arti penting dari penulisan ini adalah untuk mengetahui dan menganalisis kedudukan Akta Perjanjian Pengikatan Jual Beli dalam proses pemblokiran buku tanah yang dilakukan pembeli pada kantor pertanahan dan bentuk perlindungan hukum yang diberikan kantor pertanahan kepada pihak yang dirugikan karena pemblokiran oleh pembeli berdasarkan Akta Perjanjian Pengikatan Jual Beli. Hasil dari penelitian ini adalah kedudukan akta perjanjian pengikatan jual beli dalam proses pemblokiran buku tanah yang dilakukan oleh pihak pembeli pada kantor pertanahan hanya sebagai alat bukti telah terjadinya penyerahan secara nyata dan penyerahan yuridis antara penjual dan pembeli atas objek jual beli, bukan sebagai persyaratan administratif permohonan pemblokiran pada kantor pertanahan. Kantor pertanahan memberikan perlindungan hukum dengan melaksanakan ketentuan Pasal 125 dan Pasal 126 Peraturan Menteri Agraria/Kepala Badan Pertanahan Nasional Nomor 3 Tahun 1997 dengan membatasi pihak yang ingin mengajukan permohonan blokir ke kantor pertanahan adalah pihak yang memiliki dasar hukum yang kuat untuk mengajukan permohonan blokir dalam upaya mempertahankan haknya tersebut sehingga tidak akan merugikan pihak lain.
CACAT HUKUM DALAM HIBAH SEBAGAI PERJANJIAN SEPIHAK DAN IMPLIKASINYA
Authors: Mandasari Nila 
Published: July 2019

AbstractGrant Agreement in the modern era has been regarded as a normal thing, but most of the implementations found incorrect according to legislation. The method used in this research is juridical empirical, specification of this research is descriptive. Deed of grant can be canceled after the grant was not carried out as required, that is done by notary deed pursuant to Article 1682 joint 1683 of the Civil Code. Then if the donated goods are not the property of the grantor in violation of the provisions of Article 200 Compilation of Islamic law is an act which is done in the framework of the delivery of goods / items from the grantor to the grantee and the goods delivered are the properties of their own. Then, if the grantor proved to have died when the deed of grant was made contrary to the provisions of Article 1666 of the Civil Code clearly confirms that the grant is an agreement by who provides grants, at the time of his life, freely and irrevocably, handed some object for the purposes of the grant recipient to take advantage of it. Then grant that exceed 1/3 of his property contrary to the provisions of Article 210 paragraph (2) Compilation of Islamic Law. As a result the consequences of legal defect for internal party and the third party of the cancellation of the deed of grant ownership of the property / land will be returned to the grantor / owner of the land. AbstrakPembuatan Perjanjian Hibah di era modern sudah dianggap sebagai hal yang lumrah, akan tetapi dalam implementasinya banyak pembuatan perjanjian hibah tidak sesuai dengan peraturan perundang-undangan yang berlaku. Metode pendekatan yang digunakan dalam penelitian ini adalah yuridis empiris, spesifikasi penelitian ini adalah deskriptif analitis. Pemberian hibah sebagai perjanjian sepihak terjadi cacat hukum jika hal tersebut tidak dengan akta Notaris berdasarkan ketentuan Pasal 1682 jo 1683 KUHPerdata. Apabila barang yang dihibahkan bukan barang milik pemberi hibah, melanggar ketentuan Pasal 200 Kompilasi Hukum Islam yaitu suatu perbuatan yang dilakukan dalam rangka penyerahan suatu barang/benda dari pemberi hibah kepada penerima hibah dan barang yang diserahkan tersebut adalah barang milik sendiri. Kemudian apabila si pemberi hibah terbukti sudah meninggal dunia ketika akta hibah dibuat, bertentangan dengan ketentuan Pasal 1666 KUHPerdata menegaskan bahwa hibah adalah suatu perjanjian dengan mana si penghibah, di waktu hidupnya, dengan cuma-cuma dan dengan tidak dapat ditarik kembali, menyerahkan sesuatu benda guna keperluan si penerima hibah yang menerima penyerahan itu. Kemudian pengibahan yang melebihi 1/3 harta bendanya bertentangan dengan ketentuan Pasal 210 ayat (2) Kompilasi Hukum Islam. Implikasi dari akta hibah yang cacat hukum bagi pihak interrnal dan pihak ketiga adalah kepemilikan atas harta/tanah tersebut akan kembali kepada pemberi hibah/pemilik tanah.
PERLINDUNGAN HAK CIPTA ATAS MOTIF BATIK BUKETAN SEBAGAI WARISAN BUDAYA DI PEKALONGAN (Studi Terhadap Karya Seni Batik Tradisional Pekalongan)
Authors: Mustika Asri Cahaya 
Published: July 2019

Abstract The legal basis for the protection of traditional works of art is contained in Copyright Act of 2014 that the work of unknown copy of the inspector then the work is protected by the State. In fact, this article has not been optimal in protecting artwork especially Batik Buketan Pekalongan because it is still only limited to acknowledged but legally not yet have strong protection. The method used in this research is with empirical juridical approach.Research findings show that in the implementation on the field, UUHC Year 2014 can not accommodate the Copyright protection of traditional batik motif as part of folklore, this is because the Copyright Law still has some weaknesses if it is to be applied consequently in order to protect folklore. Therefore, special arrangement of folklore is required, with the establishment of a separate regulatory framework concerning traditional knowledge / folklore (sui generis). Keywords: Protection, Batik motif, Traditional Pekalongan. Abstrak Dasar hukum perlindungan karya seni tradisional tertuang pada UU Hak Cipta Tahun 2014 bahwa karya cipta yang tidak diketahui peniliknya maka karya tersebut dilindungi oleh Negara. Faktanya pasal ini belum optimal melindungi karya seni khususnya Batik Buketan Pekalongan karena masih karya tersebut hanya sebatas diakui namun secara legalitas belum memiliki perlindungan yang kuat. Metode yang digunakan dalam penelitian ini adalah dengan pendekatan yuridis empiris. Hasil temuan menunjukkan bahwa dalam implementasi di lapangan, UUHC Tahun 2014 belum bisa mengakomodir perlindungan Hak Cipta atas motif batik tradisional sebagai bagian dari folklore, hal ini dikarenakan UU Hak Cipta masih mempunyai beberapa kelemahan bila hendak diterapkan untuk melindungi folklore, yakni perlunya pengaturan secara khusus terhadap folklore, yaitu dengan dibentuknya suatu kerangka pengaturan tersendiri mengenai pengetahuan tradisional/folklore (sui generis). Kata Kunci: Perlindungan, Motif Batik, Tradisional Pekalongan.
EKSEKUSI JAMINAN FIDUSIA TERHADAP PEMBIAYAAN BERMASALAH DI KOPERASI BAITUL MAAL WA TAMWIL KABUPATEN SEMARANG
Authors: Rahmawan Rahmawan , Dja’is Mochammad 
Published: July 2019

The purpose of executing the object of the fiduciary is to guarantee the repayment of the credit facility granted by banking institutions as creditors. The problem in this study is on the execution of motor vehicles in the Baitul Maal Tanwil in the district of Semarang cause many problems. This thesis uses normative juridical research method and empirical research data support. Based on qualitative analysis known that prevention fiduciary execution problems, can be done by registration of fiduciary security object at the Ministry of Justice and Human Rights through an online application method, but to do an execution must be done on the spot, online application method of the execution of fiduciary can make sure a justice and legal standing for creditors to execution of fiduciary object, and by registering online fiduciary guarantee object, the object is expected to issue execution fiduciary. Keywords: Fiduciary, Execution Fiduciary, Baitul Maal Tamwil. Abstrak Tujuan pelaksanaan eksekusi objek jaminan fidusia adalah untuk menjamin pelunasan terhadap fasilitas kredit yang diberikan oleh lembaga perbankan selaku kreditor. Pelaksanaan eksekusi objek jaminan fidusia pada kendaraan bermotor pada Baitul Maal Tanwil di wilayah Kabupaten Semarang menimbulkan berbagai macam permasalahan. Penulisan tesis ini menggunakan metode penelitian yuridis normatif dan didukung data penelitian empiris. Berdasarkan analisis kualitatif diketahui bahwa pencegahan permasalahan pelaksanaan eksekusi jaminan fidusia, dapat dilakukan dengan melakukan pendaftaran objek jaminan fidusia pada kantor Kementerian Hukum dan Hak Asasi Manusia melalui metode pendaftaran secara online, tetapi pelaksanaan eksekusi jaminan fidusia tetap dilakukan secara langsung di lapangan, pendaftaran objek jaminan fidusia secara online, memberikan suatu kepastian hukum atau legal standing yang jelas bagi kreditor di dalam mengeksekusi objek jaminan fidusia. Kata kunci : Fidusia, Eksekusi Jaminan Fidusia, Baitul Maal Tamwil.