bluuebunny/crossref_metadata_2025_split huggingface dataset:
TP53 mutations as potential prognostic markers for specific cancers: Analysis of data from The Cancer Genome Atlas and the International Agency for Research on Cancer TP53 Database
Authors: Li Victor , Li Karen , Li John T. 
Published: July 2018

AbstractMutations in the tumor suppressor gene TP53 are associated with a variety of cancers. Therefore, it is important to know the occurrence and the prognostic effects of TP53 mutations in certain cancers. Over 29,000 cases of TP53 mutations were obtained from the April 2016 release of the Internal Agency for Research on Cancer (IARC) TP53 Database, and 7,893 cancer cases were compiled in the cBioPortal for Cancer Genomics from the 33 most recent studies of The Cancer Genome Atlas (TCGA). The data was analyzed, and it was found that the majority of TP53 mutations were missense and the major mutational hotspots were located at codons 248, 273, 175, and 245 in exons 4–8 for somatic mutations with the addition of codon 337 and other mutations in exons 9–10 for germline mutations. Out of 33 TGCA studies, the effects of TP53 mutations were statistically significant in ten cancers (ovarian serous cystadenocarcinoma, lung adenocarcinoma, hepatocellular carcinoma, head and neck squamous cell carcinoma, acute myeloid leukemia, clear cell renal cell carcinoma (RCC), papillary RCC, chromophobe RCC, uterine endometrial carcinoma, and thymoma) for survival time and in six cancers (ovarian serous cystadenocarcinoma, pancreatic adenocarcinoma, hepatocellular carcinoma, chromophobe RCC, acute myeloid leukemia, and thymoma) for disease-free survival time. Also, it was found that the most common p53 mutation in hepatocellular carcinomas (R249S) was a much better indicator for poor prognosis than TP53 mutations as a whole.Author summaryThe TP53 gene codes for the tumor suppressor protein, p53, which is essential for DNA repair, cell cycle arrest, and apoptosis. It is commonly inactivated or partially disabled by mutations, contributing to the development of a variety of human cancers. In this study, over 29,000 cases from the April 2016 release of the International Agency for Research on Cancer TP53 Database (IARC) were analyzed to determine the distribution of mutations in the TP53 gene. Data was also collected from the 33 most recent The Cancer Genome Atlas (TCGA) studies to determine the prevalence of TP53 mutations in cancers and their effects on survival and disease-free survival time. It was found that there were statistically significant differences between cases with and without TP53 mutations in ten cancers when comparing survival time, and in six cancers when comparing disease-free survival time. This indicates that TP53 mutations are potential prognostic markers that can be used to further improve the accuracy of predicting the survival time and disease-free survival time of cancer patients.
Understanding the motives of consumers of mezcal in Mexico
Authors: López-Rosas Carolina Andrea , Espinoza-Ortega Angélica 
Published: July 2018

Purpose
The purpose of this paper is to characterize the consumers of mezcal in México based on their motivations, identifying different groups of consumers and their demographic characteristics.

Design/methodology/approach
A questionnaire based on the Food Choice Questionnaire was applied to 310 consumers: 154 directly to mezcal consumers in three “mezcalerías” (mezcal bars) and 156 through five social networking communities of mezcal consumers. The data obtained were analysed using multivariate statistics, factor and cluster analysis.

Findings
The results show that the search for tradition is the determining buying motivation, whereas quality seals do not exert a significant influence. Four profiles of mezcal consumers can be identified according to their consumption patterns: consumer linked to the territory, traditional consumer, consumer in transition and social consumer. The predominant demographic characteristics in the four consumer groups described a male, between 20 and 39 years old, single, childless, with professional education and employed. The overall results reveal a consumer who shares the quality criteria established by mescal-producing communities and is strongly interested in traditionally processed drinks.

Originality/value
In México, there are two important distilled drinks, tequila and mezcal. There is ample research on the first one, but there is less research on mezcal, despite it has an annual increase of 45 per cent in consumption. Most of the research work has been focused on aspects of diversity, sustainability and productivity, but there are not studies on the factors that affect mezcal consumption. Thus, this paper aims to characterize the consumers of mezcal, based on their motivations.
Heterogeneous effects of rural land property mortgage loan program on income
Authors: Yang Xi , Luo Jianchao , Yan Wenshou 
Published: July 2018

Purpose
The innovative rural land property right mortgage loan program (RLPRMLP) provides a new channel for farmers to secure borrowing from microfinance institutions. Farmers’ land property right could be used as collateral to deal with moral hazard and adverse selection issues. The purpose of this paper is to document the effects of the RLPRMLP on households’ income using a unique data set from 1,279 households’ survey in Western China during 2012–2014.

Design/methodology/approach
At the first stage, the authors evaluate the impacts of RLPRMLP on households’ income to get the benchmark results when the authors control household’s observed and unobserved characteristics. To address the potential endogeneity issue resulting from the self-selection of farmers into the rural financial market, the authors apply the treatment effect model to identify the csusal effects of the innovative loan approach on a household’s income.

Findings
The empirical results favor the belief that participating in the RLPRMLP helps the households improve their total income (at least by 20.2 percent) and income per capita. This income-improving channel is only through agricultural sector, rather than through non-agricultural sector which potentially helps to deal with the inequality issue within poor regions. The results are robust when the authors control households’ characteristics, including observed and unobserved, and solve the endogeneity issue. Participating in the RLPRMLP could encourage farmers to invest more in the agricultural sector and increase agricultural productivity, which is the main mechanism of the income-improving effect of the RLPRMLP.

Originality/value
The innovative mortgage loan program provides a new channel for farmers to get loan. Land property right reform is being currently applied in rural China. Testing the effectiveness of combining land property right and microfinance loan method is necessary for the government policy making and development of rural areas. The findings are striking. The income improvement mechanism mainly works through agricultural sector, potentially because of the reform of land property, contributing to the increase of marginal product of land, i.e., the increase of agricultural productivity. These could help the development of microfinance theory, and the innovative loan method could be applied to other developing countries.
Demand and supply of opiates in an unregulated market
Authors: Vitaliano Donald F. 
Published: July 2018

Purpose
The purpose of this paper is to estimate the demand and supply of opiates in the USA during the period 1870–1914 when the market was virtually unregulated.

Design/methodology/approach
The price and quantity of opiates is econometrically estimated using a data set constructed primarily from pharmaceutical trade journals.

Findings
Per capita opiate consumption varies in inverse proportion to its price, a price elasticity of demand of unity. The supply of opiates to the USA is perfectly elastic, a horizontal line, implying the USA was a “price-taker” in the world market for opium. The number of medical schools, a proxy for the state of medical science, significantly effects opiate consumption, as does the import tariff on opium.

Research limitations/implications
Opiate use, both medicinal and addictive, is highly responsive to purely the economic forces of price and income. The influential role of the medical profession in shaping the pattern of consumption is confirmed. Data limitations prevent making substantive statements about usage of the various sub-categories of opium, requiring all opium to be treated as equivalent units of morphine sulfate.

Practical implications
Decriminalized access to opiates and other addictive substances is likely to result in a significant increase in usage, which could be controlled by taxation.

Originality/value
Prior studies of unregulated opiate demand and supply have covered Indonesia and Taiwan under colonial government monopoly, not a major western country user like the USA. Also, this paper uses a newly created consistent set of inflation-adjusted opiate prices covering a long period (1870–1914).
Human resource function, unions and varieties of capitalism
Authors: Cristiani Alvaro , Peiró José María 
Published: July 2018

PurposeThe purpose of this paper is to explore varieties of capitalism (VoC) as a moderator of the effect of: the strategic HR function role; and the level of union presence on the adoption of different human resource management (HRM) practices categorized as either person-centered or performance-centered.Design/methodology/approachThe authors use data on both multinationals and locally owned firms from 14 OECD countries, collected through the Cranet 2009 survey. The hypotheses of the proposed model were tested using hierarchical multiple regression analysis.FindingsEvidence shows that the strategic HR function is positively related to the adoption of both types of HRM practices, whereas higher levels of union presence inhibit the adoption of performance-centered practices and promote the adoption of person-centered practices. In addition, although VoC does not show any significant direct effects on HR practices, there is a moderating effect of VoC on the HR function role – HRM practices and union presence – HRM practices relationships.Research limitations/implicationsThe use of survey data with single respondents might produce reliability problems. Additionally, the data used are cross-sectional, which means that causality cannot be determined.Practical implicationsManagers in multinationals corporations and local firms must be aware of the distinct effects of the strategic HR function and trade union presence in different market economies. In particular, special attention must be paid when a firm expands globally, “outside the reach” of the national market economy or type of capitalism, and operates in different VoC.Originality/valueThe present paper contributes to better understanding the influence of VoC, not only on HRM practices, as in previous research, but also on the relationships between the HR function role and the level of union presence and the types of practices promoted.
The impact of school principals on implementing effective teaching and learning practices
Authors: Fourie Elsa 
Published: July 2018

PurposeThe purpose of this paper is to identify limitations in managing the implementation of effective teaching and learning in township ECD centres.Design/methodology/approachThis research was grounded in a community-based participatory research approach. A qualitative research design was utilised because phenomena could be studied in terms of the meanings of people. Elements of grounded theory, situational analysis and community-based participatory research were blended. The qualitative research design involved semi-structured face-to-face interviews with teachers in township ECD centres.FindingsThe findings from this research made it evident that principals of ECD centres were often absent; had not been trained to manage an ECD centre; had limited skills to manage finances; did not communicate with parents or teachers; and did not motivate teachers to achieve goals or to improve their qualifications.Practical implicationsChallenges that could impede the effective implementation of an intervention programme should be identified and addressed. Principals of ECD centres should be empowered to manage their centres effectively. A training programme aimed at empowering principals of ECD centres has been developed and will be implemented after consultation with the gatekeeper and principals of the ECD centres.Originality/valueThe findings of this research could be used by principals and researchers to reflect on management practices in ECD centres. A challenge for principals is to acknowledge the principles of effective management and to close the gap between current practices and effective management practices. Interventions from academics are essential to enhance the quality of teaching and learning in ECD centres.
Determinants of effectiveness in public higher education-students’ viewpoint
Authors: Kaur Harpreet , Bhalla G.S. 
Published: July 2018

PurposeThe purpose of this paper is to examine the determinants of effectiveness in public colleges of Punjab (India) from the students’ perspective and the impact of these determinants on the satisfaction level of students. The study further explores the difference in the overall satisfaction of students’ toward college effectiveness on the basis of demographic variables.Design/methodology/approachThe study uses a survey approach. The sample comprises of 369 students from 19 public/government general degree colleges of Punjab (India). Exploratory factor analysis (EFA) has been used to explore the determinants of public colleges and structural equation modeling (SEM) has been used to analyze the impact of these determinants on the satisfaction of students.t-Test and ANOVA have been used to examine the difference in students’ satisfaction on the basis of their demographic variables.FindingsThe research instrument has been tested for both reliability and validity. The findings showed that the eight determinants of the satisfaction of students toward public colleges, namely academic environment, college administration, students support services, learning material, infrastructure facilities, placement services, extracurricular activities and financial administration. These, eight independent variables have been entered into SEM. The SEM model shows that infrastructure facilities, academic environment, learning material, college administration, extracurricular activities and financial administration have a positive and significant impact on the students’ satisfaction. On the basis of demographic variables, significant differences in overall satisfaction have been found for gender and level of education.Practical implicationsPublic higher education sector in Punjab suffers from many limitations. Students are the internal customers of educational institutions and their satisfaction toward higher educational institutions will make every learner’s mind and policymakers in the field of education think seriously about bringing reforms in the higher education sector in Punjab.Originality/valuePunjab, a well-known state of northern India is a leader in providing higher education. But, it is a fact that public higher education sector in Punjab has been facing many challenges. Student satisfaction is the central goal of any institution and this research helps to develop new insight in the quality of public higher education.
Examining situational continuous mobile game play behavior from the perspectives of diversion and flow experience
Authors: Liu Yanni , Liu Dongsheng , Yuan Yufei , Archer Norm 
Published: July 2018

Purpose
The purpose of this paper is to investigate users’ continuous adoption behaviors on mobile game playing from the perspective of situational habit formation.

Design/methodology/approach
Based on the literature research, a continuous adoption model for situational mobile game is proposed. And the research model is assessed based on data gathered from a sample of 226 mobile game players by employing the structural equation model methodology.

Findings
The results show that situational cues represented by availability, perceived ease of use and diversion lead to repeated performance that can be represented by flow experience and satisfaction in the situational mobile game playing context. But only flow experience and diversion influence continuous usage directly. Additionally diversion, as a critical situational variable, not only indirectly affects continuous usage intention through flow experience, but also directly affects continuous usage intention for situational mobile game playing.

Originality/value
Mobile game adoption has been studied from different perspectives, but most research is based on the technology acceptance model. They could not explain the common fact that young people tend to be highly motivated by mobile games and can be regarded as pro-active mobile game players, but many people play mobile games only when they are bored and need a diversion. So this study attempts to illustrate the phenomena to fill the gaps.
Tourism sustainability: economic benefits and strategies for preservation and conservation of heritage sitesin Southeast Asia
Authors: Chong Kar Yee , Balasingam Ann Selvaranee 
Published: July 2018

Purpose
This paper aims to provide empirical insights about the economic benefits as well as the useful strategies to preserve and conserve heritage sites in Southeast Asia. The benefits of heritage tourism include high tourist arrivals and receipts, the multiplier effects within the industry and creation of employment opportunities for the local community.

Design/methodology/approach
This paper used systematic literature review of secondary data to discover the benefits and strategies for preserving and conserving heritage sites. The data were obtained from peer-review journals, documentary analysis, industrial report, working paper and books.

Findings
This paper provides empirical insights about the economic benefits as well as the useful strategies to preserve and conserve heritage sites in Southeast Asia. The benefits of heritage tourism include high tourist arrivals and receipts, the multiplier effects within the industry and creation of employment opportunities for the local community. The strategies proposed include stakeholder collaboration and involvement, stakeholder empowerment and the adaptive reuse approach.

Practical implications
This research is useful for sites’ managers as local stakeholders are highly motivated in participating in the decision-making process on the future development of heritage sites. Involving and empowering stakeholders in heritage management programs increase the stakeholders’ values and willingness to participate in heritage preservation program. In addition, the implementation of adaptive reuse approach enables the conservation of heritage originality and values.

Originality/value
This paper has discovered three benefits and three strategies toward positive heritage management. Stakeholders’ involvement and collaboration is the easiest way to promote heritage management programs and empower stakeholders. Finally, adaptive reuse program is the hardest approach, but the most beneficial approach in maintaining the value and rejuvenating the heritage sites.
Nitrogen fixation and foliar nitrogen do not predict phosphorus acquisition strategies in tropical trees
Authors: Soper Fiona M. , Nasto Megan K. , Osborne Brooke B. , Cleveland Cory C. 
Published: July 2018

Abstract

The mechanistic links between nitrogen (N) availability and investment in plant phosphorus (P) acquisition have important implications for plant growth, species distributions, and responses to CO2 fertilization under global change, especially in P‐poor tropical ecosystems. Currently, it is unclear whether investment in strategies that enhance plant P acquisition (arbuscular mycorrhizal, AM; colonization or root phosphatase activity, RPA) are determined primarily by phylogeny, or whether these strategies differ among N2‐fixing legumes and nonfixing plants as a result of differing N availability.

We hypothesized that plant N status, which can vary widely independent of N fixation, correlates with investment in P acquisition, because: (a) N and P concentrations scale in plant tissue indicative of coupled demand and (b) plants with more N may have more resources available to allocate to acquisition strategies.

We grew seedlings of eight tropical tree species from three families (including three N2‐fixing and one nonfixing legume) under greenhouse conditions in native forest soil for four months. Species represented almost the full range of foliar N observed in tropical trees.

Neither foliar N nor P concentrations correlated with investment in P acquisition. Across all species, we found an inverse relationship between investment in AM colonization and RPA, but this trade‐off was unrelated to foliar N or P and did not differ between functional types (i.e., N2 fixers vs. nonfixers).

Within legumes (family Fabaceae), two strategies were evident that were unrelated to fixation status. High‐fixing Inga and nonfixing Dialium displayed high foliar N and P concentrations and greater proportional investment in RPA versus AM, while lower fixing Ormosia species were characterized by lower foliar nutrient concentrations and proportionally more investment in AM.

Synthesis.Investment in P acquisition strategies in tropical trees is not dependent on foliar N or functional group, but instead may be controlled in part by resource trade‐offs. High diversity in nutrient strategies between related species cautions again the use of simple functional groupings to draw conclusions about nutrient acquisition in tropical trees.
Agency, activation and compatriots: the influence of social networks on health‐seeking behaviours among Sri Lankan migrants and Anglo‐Australians with depression
Authors: Antoniades Josefine , Mazza Danielle , Brijnath Bianca 
Published: July 2018

AbstractThe nexus between social networks and illness behaviours is important in uptake of health care, however scant research has explored this relationship in South Asian migrants living with mental illness. We explored the interplay between culture, social networks and health seeking in Sri Lankan migrants and Anglo‐Australians living with depression. Forty‐eight in‐depth interviews were conducted and data were analysed through the theoretical prism of the network episode model. Results showed that social networks were important in negotiating care. Decisions to initiate care occurred along a continuum of choice and agency; some took charge of their care, others were coerced into care, however some Sri Lankan migrants were led through various informal channels of care. Selective activation of compatriots – those perceived to understand mental illness‐became increasingly important to participants through their illness careers. Compatriots were considered of greater benefit as participants progressed through depression than otherwise meaningful social networks based on ethnicity, culture and kinship. We argue that the role of social networks is pivotal in uptake of formal care, and engaging with communities to improve responses of social networks to mental illnesses may provide a bottom‐up avenue for improving uptake of mental health services in migrant communities.