bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health impact and cost-effectiveness of vaccination using potential next-generation influenza vaccines in Thailand: a modelling study
Authors: Procter Simon R , Waterlow Naomi R , Radhakrishnan Sreejith , van Leeuwen Edwin , Meeyai Aronrag , Cooper Ben S , Chuenkitmongkol Sunate , Teerawattananon Yot , Eggo Rosalind M , Jit Mark 
Published: November 2024

IntroductionThailand was one of the first low- and middle-income countries to publicly fund seasonal influenza vaccines, but the lack of predictability in the timing of epidemics and difficulty in predicting the dominant influenza subtypes present a challenge for existing vaccines. Next-generation influenza vaccines (NGIVs) are being developed with the dual aims of broadening the strain coverage and conferring longer-lasting immunity. However, there are no economic evaluations of NGIVs in Thailand.MethodsWe estimated the health impact and cost-effectiveness of NGIVs in Thailand between 2005 and 2009 using a combined epidemiological and economic model. We fitted the model to data on laboratory-confirmed influenza cases and then simulated the number of influenza infections, symptomatic cases, hospitalisations and deaths under different vaccination scenarios based on WHO-preferred product characteristics for NGIVs. We used previous estimates of costs and disability adjusted life years (DALYs) for influenza health outcomes to estimate incremental net monetary benefit, vaccine threshold prices and budget impact.ResultsWith the current vaccine programme, there were an estimated 61 million influenza infections. Increasing coverage to 50% using improved vaccines reduced infections to between 23 and 57 million, and with universal vaccines to between 21 and 49 million, depending on the age groups targeted. Depending on the comparator, threshold prices for NGIVs ranged from US$2.80 to US$12.90 per dose for minimally improved vaccines and US$24.60 to US$69.90 for universal vaccines.ConclusionInfluenza immunisation programmes using NGIVs are anticipated to provide considerable health benefits and be cost-effective in Thailand. However, although NGIVs might even be cost-saving in the long run, there could be significant budget implications for the Thai government even if the vaccines can be procured at a substantial discount to the maximum threshold price.
Immunogenicity of adalimumab reference product and adalimumab-adbm in patients with rheumatoid arthritis, Crohn’s disease and chronic plaque psoriasis: a pooled analysis of the VOLTAIRE trials
Authors: Strand Vibeke , McCabe Dorothy , Bender Shaun 
Published: November 2024

ObjectiveThis post hoc analysis compared the immunogenicity of the biosimilar adalimumab-adbm (Cyltezo) with the adalimumab reference product (RP; Humira) across indications, including rheumatoid arthritis (RA), Crohn’s disease (CD) and plaque psoriasis (PsO), and by patient sex in the VOLTAIRE trials programme.MethodsIn each active-comparator randomised controlled trial (RCT), immunogenicity was assessed at various time points by the proportion of patients with antidrug antibodies (ADAs) and neutralising antibodies (nAbs), using acid dissociation followed by electrochemiluminescence assay. Assay sensitivity was 50 ng/mL, and drug tolerance was ≥30 µg/mL (free drug) at the low positive control level.ResultsMinor differences in immunogenicity parameters (ADAs, ADA titres and nAbs) were evident between adalimumab-adbm and adalimumab RP across these three immune-mediated inflammatory diseases (IMIDs). The proportion of ADA-positive and nAb-positive patients increased from baseline over time in all three RCTs, as expected, and was similar in the RA and CD RCTs but with higher numbers of ADA-positive and nAb-positive patients reported in the PsO trial. Subgroup analysis by patient sex showed the same trend.ConclusionsDifferences among the RCTs may partially be explained by concomitant background therapy (methotrexate) in the RA trial, stable doses of azathioprine, 6-mercaptopurine or methotrexate in 36% of patients with CD and absence of background therapy in the PsO RCT. The analyses further confirm the biosimilarity of adalimumab-adbm with the adalimumab RP across IMIDs and provide supporting evidence that adalimumab-adbm is an interchangeable biosimilar with consistent clinical results in patients originally treated with the RP.Trial registration numbersVOLTAIRE-RA (NCT02137226; EudraCT 2012-002945-40); VOLTAIRE-CD (NCT02871635; EudraCT 2016-000612-14); VOLTAIRE-PsO (NCT02850965; EudraCT 2016-000613-79).
Which reference groups matter for Taiwanese high school adolescent smoking? A card sorting study
Authors: Tsai Han-Yi , Shih Shu-Fang , Tsai Tzu-I 
Published: November 2024

BackgroundAdolescence represents a pivotal period for the initiation of smoking behaviours. While family, peer and social groups serve as significant reference groups influencing adolescents’ decision-making process, there remains a paucity of research that examines how diversified reference groups influence their smoking decisions.ObjectiveThe objective is to compare normative and informative influences given by different reference groups on adolescents’ smoking decision-making.DesignThis study applied reference group theory and used the card sorting technique. Adolescents were presented with 16 cards portraying various reference groups and 27 cards portraying different types of reference group influences. They were asked to construct sentences as smoking-elicited and smoking-inhibited cues and ranked these influences based on their relevance to their smoking decision-making.ParticipantsThe participants were recruited from four cities in the North, Central, South and East regions of Taiwan. The study sample consisted of 297 Taiwanese 11th graders drawn from high schools, vocational high schools and night schools.Primary outcome measuresThe most influential reference group among smokers, former smokers and never smokers.ResultsOur results of multivariable logistic regression show that for current smokers, having a smoking best friend (aOR=7.58,p<0.01), having a smoking colleague (aOR=3.83,p<0.01) and participating in ceremonial dance performances (aOR=4.62,p<0.01) are more likely to smoke. Peers play an important role in providing smoking-elicited cues for current smokers. Families provided the most smoking-inhibited cues for former and never smokers. Normative influences such as encouraging adolescent smoking provided more cues for adolescents than informative influences such as releasing stress by smoking.ConclusionsAdolescent smoking behaviour was influenced by peer norms, while former and non-smoking behaviours are associated with family norms. Therefore, tobacco prevention efforts should focus more on family-level interventions to discourage smoking initiation. Smoking cessation programmes for current smokers should address the reduction of peer pressure to smoke. Moreover, schools and community partners should collaborate to develop effective smoking cessation strategies, particularly for high-risk groups such as adolescents who involved in ceremonial dance performance.
Inappropriate antibiotic prescription for acute tonsillitis in low- and middle-income countries (LMICs): a systematic review and meta-analysis protocol
Authors: Bola Siafa Antoine , Choffor-Nchinda Emmanuel , Andjock-Nkouo Yves Christian 
Published: November 2024

IntroductionTonsillitis is a self-limiting inflammatory process of the tonsils. In high-income countries, guidelines have been developed to decide if a patient needs an antibiotic or not. These guidelines help to reduce unnecessary antibiotic prescriptions and prevent the development of antimicrobial resistance (AMR). In low- and middle-income countries (LMICs), medical practitioners have the tendency to prescribe antibiotics in all cases of tonsillitis; there is an overprescription of antibiotics. These prescriptions are probably unjustified and seem to be responsible for the increased AMR seen in developing countries. The aim of this review will be to estimate the proportion of unjustified antibiotic prescriptions in LMICs.Methods and analysisWe will conduct a systematic review of all observational studies on the diagnosis and treatment of tonsillitis in LMICs. The selected database will include PubMed, Web of Sciences Global Index Medicus and the Grey literature. The search will include studies published from January 2012 until December 2024. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and bias will be assessed by a Risk of Bias Assessment Tool for observational studies by Hoyet al. A meta-analysis will be conducted for homogeneous studies, eventually using the random effect model. Subgroup analysis will include a period of study, study quality, countries and/or subregions of LMICs involved, study setting, age of participants, tools and definition used.Ethics and disseminationFormal ethical approval is not required, as primary data will not be collected. The results will be disseminated through peer-reviewed publications and presented at scientific conferences.PROSPERO registration numberCRD 42022384957
Development and validation of a clinical prediction tool to estimate survival in community-dwelling adults living with dementia: a protocol
Authors: Bonares Michael , Fisher Stacey , Clarke Anna , Dover Katie , Quinn Kieran , Stall Nathan , Isenberg Sarina , Tanuseputro Peter , Li Wenshan 
Published: November 2024

IntroductionA clinical prediction tool to estimate life expectancy in community-dwelling individuals living with dementia could inform healthcare decision-making and prompt future planning. An existing Ontario-based tool for community-dwelling elderly individuals does not perform well in people living with dementia specifically. This study seeks to develop and validate a clinical prediction tool to estimate survival in community-dwelling individuals living with dementia receiving home care in Ontario, Canada.Methods and analysisThis will be a population-level retrospective cohort study that will use data in linked healthcare administrative databases at ICES. Specifically, data that are routinely collected from regularly administered assessments for home care will be used. Community-dwelling individuals living with dementia receiving home care at any point between April 2010 and March 2020 will be included (N≈200 000). The model will be developed in the derivation cohort (N≈140 000), which includes individuals with a randomly selected home care assessment between 2010 and 2017. The outcome variable will be survival time from index assessment. The selection of predictor variables will be fully prespecified and literature/expert-informed. The model will be estimated using a Cox proportional hazards model. The model’s performance will be assessed in a temporally distinct validation cohort (N≈60 000), which includes individuals with an assessment between 2018 and 2020. Overall performance will be assessed using Nagelkerke’s R2, discrimination using the concordance statistic and calibration using the calibration curve. Overfitting will be assessed visually and statistically. Model performance will be assessed in the validation cohort and in prespecified subgroups.Ethics and disseminationThe study received research ethics board approval from the Sunnybrook Health Sciences Centre (SUN-6138). Abstracts of the project will be submitted to academic conferences, and a manuscript thereof will be submitted to a peer-reviewed journal for publication. The model will be disseminated on a publicly accessible website (www.projectbiglife.com).Trial registration numberNCT06266325(clinicaltrials.gov).
Post-traumatic growth, moral sensitivity and service behaviour among healthcare workers in the post-pandemic era of COVID-19 in mainland China: a cross-sectional study
Authors: Wei Liwen , Li Dianjiang , Hu Longjun , Wang Kuanlei , Wang Qin , Zhao Haijing , Wang Miaomiao , Chai Xuejiao , Wei Haibin , Yu Fenglan , Qian Mingping , Liu Xuechun , Hou Lengchen , Fan Hong , Xiaoxu Zhi , Zhang Youran 
Published: November 2024

ObjectivesTo investigate how post-traumatic growth (PTG) and moral sensitivity influence service behaviour among healthcare workers (HCWs) in mainland China post-COVID-19, with a focus on the mediating role of moral sensitivity.DesignCross- sectional survey design.SettingThis study was conducted in 27 provinces across mainland China, from 16 March to 2 April 2023.Participants1,193 HCWs, including 378 physicians and 815 nurses, were selected using convenience and snowball sampling methods.MethodsThe survey included the Post-traumatic Growth Inventory-Chinese version (PTGI-C), the Moral Sensitivity Questionnaire-Revised Chinese Version (MSQ-R-CV) and a service behaviour scale. Structural equation modelling was employed to analyse the data, focusing on the associations between PTG, moral sensitivity, and service behaviours.ResultsThe study found significant associations between PTG and moral sensitivity (r=0.49, p<0.01), with both factors positively influencing HCWs’ service behaviours. Specifically, PTG had a direct effect on service behaviours (β=0.172, p<0.01) and an indirect effect through moral sensitivity (β=0.333, p<0.01), with moral sensitivity mediating 65.8% of PTG’s impact on service behaviours. The model explained 56.0% of the variance in service behaviours, indicating a substantial influence of these psychological factors on professional conduct.ConclusionsThe findings highlight the significant role of PTG and moral sensitivity in shaping the service behaviours of HCWs in the aftermath of the COVID-19 pandemic. The study suggests that enhancing PTG and moral sensitivity through targeted interventions could improve HCWs’ service delivery and resilience, emphasising the importance of incorporating psychological and ethical training into healthcare practices to prepare for future public health crises.
Determinants of inpatient satisfaction and hospital recommendation: experiences from a cross-sectional study of a tertiary general hospital in China
Authors: Liu Xuedong , Lai Chenghong , Ye Mengliang , Xie Jiali 
Published: November 2024

ObjectivesThis study aims to investigate the satisfaction levels of inpatients and identify the determinants of inpatient satisfaction and hospital recommendations.DesignA cross-sectional study was conducted in 2022.SettingA tertiary general hospital in Sichuan Province, China.Participants271 inpatients were randomly selected and studied.Primary and secondary outcome measuresA tailored questionnaire was developed to measure inpatient satisfaction and hospital recommendation. T-test and analysis of variance were employed to compare the differences in inpatients’ demographic characteristics across five satisfaction domains. Multivariate binary logistic regression was performed to identify determinants associated with inpatient satisfaction and hospital recommendation.ResultsThe mean inpatient satisfaction score was 4.27 and the mean hospital recommendation score was 3.96. Inpatients showed the highest satisfaction with the physician care domain and the lowest satisfaction with the hospital environment domain. Statistically significant differences were observed in inpatient demographic characteristics among specific satisfaction domains. Older inpatients, those with Urban Employees and Residents Medical Insurance, from the internal medicine department, and inpatients from the hospital’s older region reported the highest levels of satisfaction. Multivariate binary logistic regression revealed that the nursing care domain was the strongest positive predictor of both inpatient overall satisfaction and hospital recommendation. Additionally, the medical procedure and hospital environment domains were strong positive predictors for hospital recommendation and inpatient overall satisfaction respectively. The hospital region domain was a strong negative predictor for inpatient overall satisfaction.ConclusionsHigher satisfaction levels do not necessarily correlate with an increased likelihood of hospital recommendation. Inpatient satisfaction levels vary significantly based on factors such as age, gender, insurance type, hospital clinical department and region. The domains of nursing care and medical procedure are the influencing factors associated with inpatient overall satisfaction. The domains of nursing care, hospital environment and hospital region are the influencing factors of inpatient hospital recommendation.
Economic effects of priority setting in healthcare: a scoping review of current evidence
Authors: Leskelä Riikka-Leena , Vanhala Antero , Gehrmann Katariina , Haapatalo Erik , Ranta Jussi , Patja Kristiina , Kousa Ilona , Tapanainen Pasi , Mika Pantzar , Tikkinen K , Ignatius Eveliina , Ojanen Tuomas , Torkki Paulus 
Published: November 2024

ObjectivesStudy objective was to map the current literature on the economic effects of priority setting at the system level in healthcare.DesignThe study was conducted as a scoping review.Data sourcesScopus electronic database was searched in June 2023.Eligibility criteriaWe included peer-reviewed articles published 1 January 2020–1 January 2023. All study designs that contained empirical evidence on the financial effects or opportunity costs of healthcare priority setting were included excluding disease, condition, treatment, or patient group-specific studies.Data extraction and synthesisTwo independent researchers screened the articles, and two additional researchers reviewed the full texts and extracted data. We used Joanna Briggs Institute checklists to assess the quality of qualitative, quasi-experimental and economic evaluations and the mixed methods appraisal tool for the mixed method studies. Synthesis was done qualitatively and through descriptive statistics.Results8869 articles were screened and 15 fulfilled the inclusion criteria. The most common study focus was health technology assessment (7/15). Other contexts were opportunity costs, effects of programme budgeting and marginal analysis, and disinvestment initiatives. Priority setting activities analysed in the studies did not achieve cost savings or cost containment (4/15) or have mixed findings at best (8/15). Only five studies found some indication of cost savings, cost containment or increased efficiency. Also, many of the studies consider costs only indirectly or qualitatively.ConclusionsAll in all, there is very little research addressing the pressing question of whether explicit priority setting and priority-setting methods can support cost containment on a health service system level (regional or national). There is limited evidence of the economic effects of priority setting.
Factors influencing blood donation among university students in Vojvodina, Serbia: cross-sectional study
Authors: Kocic Neda , Bujandric Nevenka , Budakov Obradovic Zorana , Grujic Jasmina , Bezanovic Milomir , Kolarovic Jovanka 
Published: November 2024

Background and objectivesThe aim of the present study was to assess the effect of sociodemographic factors on knowledge, attitudes, motivation and potential barriers of university students towards blood donation in the order to more effective donation promotion.DesignThe cross-sectional study was conducted on 1000 participants (500 non-blood donors—NBD, 276 first time blood donors—FTBD and 224 regular blood donors—RBD) from the 14 faculties of the University of Novi Sad, Serbia. The measurement tool used was a pretested survey questionnaire that included 22 questions focused on the factors influencing blood donation.ResultsMales accounted for 61.5% of participants. Average age of participants was 23.19 years, and over 80% were pursuing basic academic studies. University students: (1) correctly answered 65% of the questions about blood donation (NBD 59.2%, FTBD 59.7%, RBD 84.3%); (2) expressed 70.5% positive attitude towards donating blood (NBD 58.6%, FTBD 76.9%, RBD 89.1%), in both cases statistically significantly higher in RBD. Helping others who need blood (47.5%) was the main reason for donating blood and fear of needles (41.4%) was the most common potential barrier, with a significant statistical difference among the other factors.ConclusionsThe study demonstrates that university students show good knowledge and philanthropic attitude towards blood donation. Donation promotion should be focused on addressing potential barriers.
Health economic value of postacute oral nutritional supplementation in older adult medical patients at risk for malnutrition: a US-based modelling approach
Authors: Wang Shanshan , Shafrin Jason , Kerr Kirk W. , Schuetz Philipp 
Published: November 2024

ObjectiveTo estimate the health economic value of postdischarge oral nutrition supplement (ONS) consumption among elderly adults who were malnourished during hospitalisation.DesignA cost-effectiveness model was developed from a US payer perspective based on a recent meta-analysis of randomised trials of nutritional support following hospital discharge and studies of US hospital mortality, readmission rates and costs.Participants and settingThe target population of this study was postacute care US patients aged ≥65 years who were identified as malnourished during hospitalisation.Intervention and outcome measuresA decision-tree model was used to evaluate the impact of postacute care daily consumption of ONS compared with no ONS. Outcomes were evaluated over a 1-year time interval. Clinical outcomes of interest included readmission and mortality rates. Economic value of ONS was quantified using three different metrics: cost per death averted, cost per readmission avoided and direct cost savings resulting from changes in postacute mortality and readmission rates. The economic value of ONS was also measured by gains in quality-adjusted life-years.ResultsCompared with patients not receiving ONS after hospital discharge, use of ONS during the postacute phase reduced mortality by 36.3% and readmissions by 11.0%. Reductions in readmissions resulted in annual savings of US$1113 per person. When extrapolating the results to the estimated 1 693 034 hospitalised elderly US adults at risk of malnutrition, the use of ONS after hospital discharge would prevent 67 747 deaths and 116 570 hospital readmissions per year. With the estimated cost of nutritional support at US$175 per patient per month corresponding to two servings ONS per day, the ONS cost per death and readmission avoided was estimated at US$4380 and US$2546, respectively.ConclusionsPostdischarge use of ONS among patients at risk for malnutrition is highly cost-effective with important reductions in mortality and readmission rates.
Exploring the photoproduction of $$\rho $$ and $$\phi $$ in hadronic heavy-ion collisions
Authors: Shen Kaifeng , Wu Xin , Tang Zebo , Zha Wangmei 
Published: November 2024

AbstractSignificant enhancements of J/$$\psi $$
ψ
production have been observed by various experiments at RHIC and LHC for very low transverse momenta in peripheral heavy-ion collisions, which has ignited a surge of investigations into photon-induced processes in hadronic heavy-ion collisions (HHICs). Within this wave of research enthusiasm, the search for more photon induced products in HHICs becomes paramount. In this paper, we perform the calculation of the $$\rho $$
ρ
and $$\phi $$
ϕ
production resulting from photon-nucleus interactions in HHICs, which are crucial probes for studying the properties of quark-gluon plasma (QGP) in HHICs. Our study reveals that, in comparison to hadronic production, the photon-induced production of $$\rho $$
ρ
and $$\phi $$
ϕ
does not reach the same level of significance as that observed in J/$$\psi $$
ψ
production. Nevertheless, it remains substantial, especially in peripheral collisions, holding great promise for experimental verification in the imminent future.