bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoting mental health in out of home care in Australia
Authors: Monson Katherine , Moeller-Saxone Kristen , Humphreys Cathy , Harvey Carol , Herrman Helen 
Published: August 2019

AbstractYoung people in out of home care (OoHC) typically have worse mental health outcomes than peers who grow up within a family of origin. Innovations to improve the mental health of this group have tended to focus on pathology rather than mental health promotion and prevention of mental illnesses, and are often costly and challenging to implement. This qualitative study explored perspectives from young people with experience of OoHC in Melbourne, Australia regarding the promotion of mental health in OoHC. The study informed the subsequent development of a system-level intervention to support workers and carers in OoHC and evaluation of its implementation, the Ripple study. We conducted thematic analysis of data from interviews and focus groups with 14 young people aged 18–24 years with diverse identities and experiences of foster, kinship and residential care. We identified four key themes. These were providing a home-like environment; having someone to talk to; connecting to the wider community and having opportunities to become an active citizen. There is a need for both mental health promotion and treatment approaches in interventions to support workers and carers and young people in OoHC. Mental health promotion strategies should include a focus on enhancing existing capacities of carers and workers. Mental health promotion for young people in OoHC depends on strong intersectoral collaboration and youth participation.
A hypomorphic allele of SLC35D1 results in Schneckenbecken-like dysplasia
Authors: Rautengarten Carsten , Quarrell Oliver W , Stals Karen , Caswell Richard C , De Franco Elisa , Baple Emma , Burgess Nadia , Jokhi Roobin , Heazlewood Joshua L , Offiah Amaka C , Ebert Berit , Ellard Sian 
Published: August 2019

Abstract
We report the case of a consanguineous couple who lost four pregnancies associated with skeletal dysplasia. Radiological examination of one fetus was inconclusive. Parental exome sequencing showed that both parents were heterozygous for a novel missense variant, p.(Pro133Leu), in the SLC35D1 gene encoding a nucleotide sugar transporter. The affected fetus was homozygous for the variant. The radiological features were reviewed, and being similar, but atypical, the phenotype was classified as a ‘Schneckenbecken-like dysplasia.’ The effect of the missense change was assessed using protein modelling techniques and indicated alterations in the mouth of the solute channel. A detailed biochemical investigation of SLC35D1 transport function and that of the missense variant p.(Pro133Leu) revealed that SLC35D1 acts as a general UDP-sugar transporter and that the p.(Pro133Leu) mutation resulted in a significant decrease in transport activity. The reduced transport activity observed for p.(Pro133Leu) was contrasted with in vitro activity for SLC35D1 p.(Thr65Pro), the loss-of-function mutation was associated with Schneckenbecken dysplasia. The functional classification of SLC35D1 as a general nucleotide sugar transporter of the endoplasmic reticulum suggests an expanded role for this transporter beyond chondroitin sulfate biosynthesis to a variety of important glycosylation reactions occurring in the endoplasmic reticulum.
Exome sequencing identifies variants in FKBP4 that are associated with recurrent fetal loss in humans
Authors: Demetriou Charalambos , Chanudet Estelle ,   GOSgene, Joseph Agnel , Topf Maya , Thomas Anna C , Bitner-Glindzicz Maria , Regan Lesley , Stanier Philip , Moore Gudrun E 
Published: August 2019

Abstract
Recurrent pregnancy loss (RPL) is defined as two or more consecutive miscarriages and affects an estimated 1.5% of couples trying to conceive. RPL has been attributed to genetic, endocrine, immune and thrombophilic disorders, but many cases remain unexplained. We investigated a Bangladeshi family where the proband experienced 29 consecutive pregnancy losses with no successful pregnancies from three different marriages. Whole exome sequencing identified rare genetic variants in several candidate genes. These were further investigated in Asian and white European RPL cohorts, and in Bangladeshi controls. FKBP4, encoding the immunophilin FK506-binding protein 4, was identified as a plausible candidate, with three further novel variants identified in Asian patients. None were found in European patients or controls. In silico structural studies predicted damaging effects of the variants in the structure-function properties of the FKBP52 protein. These were located within domains reported to be involved in Hsp90 binding and peptidyl-prolyl cis-trans isomerase (PPIase) activity. Profound effects on PPIase activity were demonstrated in transiently transfected HEK293 cells comparing wild-type and mutant FKBP4 constructs. Mice lacking FKBP4 have been previously reported as infertile through implantation failure. This study therefore strongly implicates FKBP4 as associated with fetal losses in humans, particularly in the Asian population.
Fear of Crime, Racial Bias, and Gun Ownership
Authors: Gearhart Michael C , Berg Kristen A , Jones Courtney , Johnson Sharon D 
Published: August 2019

AbstractFirearm-related violence is a significant threat to public health and safety in America. However, research highlights a critical disparity in firearm-related deaths by race. Researchers often cite racial bias as a contributing factor for the racial disparity in firearm-related deaths. To provide a foundation for potential social work interventions, the present article discusses the results of an assessment of whether explicit racial biases toward four racial and ethnic groups (white, black, Asian, Hispanic/Latino), fear of crime, and the quantity and quality of interactions with neighbors of a different race are predictors of gun ownership. Findings suggest that explicit racial bias toward black, Asian, and Hispanic/Latino individuals is a significant predictor of gun ownership. Fear of crime and more frequent interactions with neighbors of a different race are also significant predictors of gun ownership. Taken as a whole, findings suggest that gun owners are more likely to be more vigilant toward people of color because of stereotypical assumptions that racial and ethnic minorities are more likely to be involved with crime. Social work practice and policy implications include developing interventions aimed at reducing implicit bias and identifying policies that are associated with lower levels of implicit bias among gun owners.
Framing Community-Based Interventions for Gun Violence: A Review of the Literature
Authors: Richardson Monte-Angel 
Published: August 2019

AbstractSocial workers are uniquely situated to lead community-based efforts to reduce gun violence, which has been identified as a prevalent and pressing public health concern. The current literature, however, has not addressed the frameworks guiding community-based interventions for gun violence. In the present article, a systematic literature review examines frameworks used to support community-based interventions for gun violence and to evaluate their outcomes. The search found 13 articles—unique to gun violence interventions—organized by the frameworks shaping perceptions of gun violence and community-based research. The review assessed frameworks based on their relationship to intervention stage and study outcomes. Findings suggest that these community-based gun violence interventions are shaped by systems, public health, and community mobilization frameworks. The article discusses frameworks found to be associated with successful community-based interventions and explains how the findings are relevant to future social work practice and research.
Incomplete expansion of transcatheter aortic valves is associated with propensity for valve thrombosis
Authors: Khodaee Farhan , Barakat Mohammed , Abbasi Mostafa , Dvir Danny , Azadani Ali N 
Published: August 2019

Abstract

OBJECTIVES
Clinical and subclinical leaflet thromboses are increasingly recognized complications following transcatheter aortic valve replacement. Identification of the risk factors is important to mitigate the occurrence of leaflet thrombosis in transcatheter aortic valves (TAVs) and ensure their long-term function. The goal of this study was to determine the effect of incomplete expansion of TAVs on the likelihood of leaflet thrombosis following transcatheter aortic valve replacement.

METHODS
Using experimental and computational methods, 3-dimensional unsteady flow fields of 26-mm SAPIEN 3 valves expanded to 3 different diameters (i.e. 26.0 mm, 23.4 mm and 20.8 mm) were determined in patient-specific geometries. The diameters corresponded to 100%, 90% and 80% stent expansion, respectively. To address the potential difference in the likelihood of leaflet thrombosis, blood residence time (i.e. stasis) and viscous shear stress on the surface of TAV leaflets were quantified and compared.

RESULTS
The results indicated that TAV underexpansion increased blood stasis on the TAV leaflets. Blood residence time on the surface of the leaflets after 80% and 90% TAV expansion on average was 9.4% and 4.1% more than that of the fully expanded TAV, respectively. In addition, areas of blood stasis time of more than 0.5 s, which are highly prone to platelet activation, increased linearly as the degree of TAV underexpansion increased.

CONCLUSIONS
Incomplete expansion of TAVs increases blood stasis on the surface of TAV leaflets. Regions of blood stasis promote platelet activation and thrombotic events. TAV underexpansion can therefore increase the risk of leaflet thrombosis in patients with transcatheter aortic valve replacement.
Chest wall reconstruction with a novel titanium mesh after partial sternectomy for chondrosarcoma
Authors: Aprile Vittorio , Korasidis Stylianos , Crisci Roberto , Ambrogi Marcello Carlo 
Published: August 2019

Abstract
Primitive malignant sternal tumours are extremely rare and represent less than 1% of all chest wall tumours. A combination of radical surgery and accurate reconstruction is mandatory to ensure adequate stability and to reduce paradoxical movement. To date, this is one of the few reports on a successful sternal reconstruction using a rigid titanium mesh to restore the skeletal integrity, which was then covered by bilateral muscular flaps.
On the Pronunciation Dictionaries of Contemporary German: Principles of Selection and Lemmatization of Lexical Material
Authors: Nycz Krzysztof , Tęcza Zygmunt 
Published: August 2019

Abstract
The aim of the present paper is to discuss some specific differences between four modern pronunciation dictionaries of the German language: the Großes Wörterbuch der deutschen Aussprache of 1982, DUDEN Aussprachewörterbuch of 2000, Deutsches Aussprachewörterbuch of 2009, and DUDEN Aussprachewörterbuch of 2015. This paper focuses on the principles of entry selection and lemmatization in diverse vocabulary groups (such as compounds, prefixed verbs, female noun forms denoting persons and professions, multiword expressions, foreign words, and inflected forms of individual word classes). Furthermore, sources used by the dictionaries’ authors in order to obtain entries are briefly discussed.
The potential of phase change materials in mitigating cooling load of buildings in UAE
Authors: Rashid Yasir , Ziauddin Mohammed , Mathew Bobby , Alnaimat Fadi 
Published: August 2019

Abstract
Integration of phase change materials (PCM) into building elements is explored extensively in the last decade to reduce air-conditioning demand for indoor thermal comfort. The PCM could absorb and release thermal energy as latent heat in a narrow temperature range. Several experimental studies reported energy saving and indoor temperature drop in summer conditions. However, the matter is sparsely researched in the environment of the United Arab Emirates (UAE), a region of high heat flux throughout the year. The current research provides an overview of the integration of PCM in buildings for indoor thermal comfort and energy saving in the UAE. The research highlights the problems of building-integrated photovoltaics (BIPV), e.g. efficiency drop. The significance of the PCM application in the built environment and its research gap is highlighted by reporting all the previous findings on the topic including the application of PCM in glazing, concrete and BIPV.
Widespread Changes in Positive Allosteric Modulation of the Muscarinic M1 Receptor in Some Participants With Schizophrenia
Authors: Hopper Shaun , Pavey Geoffrey Mark , Gogos Andrea , Dean Brian 
Published: August 2019

Abstract

Background
Preclinical and some human data suggest allosteric modulation of the muscarinic M1 receptor (CHRM1) is a promising approach for the treatment of schizophrenia. However, it is suggested there is a subgroup of participants with schizophrenia who have profound loss of cortical CHRM1 (MRDS). This raises the possibility that some participants with schizophrenia may not respond optimally to CHRM1 allosteric modulation. Here we describe a novel methodology to measure positive allosteric modulation of CHRM1 in human CNS and the measurement of that response in the cortex, hippocampus, and striatum from participants with MRDS, non-MRDS and controls.

Methods
The cortex (Brodmann’s area 6), hippocampus, and striatum from 40 participants with schizophrenia (20 MRDS and 20 non-MRDS) and 20 controls were used to measure benzyl quinolone carboxylic acid-mediated shift in acetylcholine displacement of [3H]N-methylscopolamine using a novel in situ radioligand binding with autoradiography methodology.

Results
Compared with controls, participants with schizophrenia had lower levels of specific [3H]N-methylscopolamine binding in all CNS regions, whilst benzyl quinolone carboxylic acid-modulated binding was less in the striatum, Brodmann’s area 6, dentate gyrus, and subiculum. When divided by subgroup, only in MRDS was there lower specific [3H]N-methylscopolamine binding and less benzyl quinolone carboxylic acid-modulated binding in all cortical and subcortical regions studied.

Conclusions
In a subgroup of participants with schizophrenia, there is a widespread decreased responsiveness to a positive allosteric modulator at the CHRM1. This finding may have ramifications it positive allosteric modulators of the CHRM1 are used in clinical trials to treat schizophrenia as some participants may not have an optimal response.
Status of the Rollout of the Meningococcal Serogroup A Conjugate Vaccine in African Meningitis Belt Countries in 2018
Authors: Bwaka Ado , Bita André , Lingani Clément , Fernandez Katya , Durupt Antoine , Mwenda Jason M , Mihigo Richard , Djingarey Mamoudou H , Ronveaux Olivier , Preziosi Marie-Pierre 
Published: August 2019

Abstract

Background
A novel meningococcal serogroup A conjugate vaccine (MACV [MenAfriVac]) was developed as part of efforts to prevent frequent meningitis outbreaks in the African meningitis belt. The MACV was first used widely and with great success, beginning in December 2010, during initial deployment in Burkina Faso, Mali, and Niger. Since then, MACV rollout has continued in other countries in the meningitis belt through mass preventive campaigns and, more recently, introduction into routine childhood immunization programs associated with extended catch-up vaccinations.

Methods
We reviewed country reports on MACV campaigns and routine immunization data reported to the World Health Organization (WHO) Regional Office for Africa from 2010 to 2018, as well as country plans for MACV introduction into routine immunization programs.

Results
By the end of 2018, 304 894 726 persons in 22 of 26 meningitis belt countries had received MACV through mass preventive campaigns targeting individuals aged 1–29 years. Eight of these countries have introduced MACV into their national routine immunization programs, including 7 with catch-up vaccinations for birth cohorts born after the initial rollout. The Central African Republic introduced MACV into its routine immunization program immediately after the mass 1- to 29-year-old vaccinations in 2017 so no catch-up was needed.

Conclusions
From 2010 to 2018, successful rollout of MACV has been recorded in 22 countries through mass preventive campaigns followed by introduction into routine immunization programs in 8 of these countries. Efforts continue to complete MACV introduction in the remaining meningitis belt countries to ensure long-term herd protection.
Childhood familial environment and adulthood depression: evidence from a Chinese population-based study
Authors: Zhou Qin , Yin Zhichao , Wu Wei , Li Ning 
Published: August 2019

Abstract

Background
Mental disorders have become an important public health issue and evidence is lacking on the impact of childhood experience on adulthood mental health in regions of low and middle income. Using national representative data from the China Health and Retirement Longitudinal Study, we aimed to explore the impact of childhood familial environment on adulthood depression.

Methods
A total of 19 485 subjects were interviewed. The survey collected information on demographic variables, variables of childhood familial environment and potential pathway variables, including childhood health status, adulthood physical health status, adulthood social support and adulthood socio-economic status (SES). Depressive symptoms were measured by the 10-item version of the Center for Epidemiological Studies Depression Scale.

Results
Parents’ physical and mental health during the subjects’ childhood were significantly associated with adulthood mental health. Mothers’ smoking, unfair treatment and low family SES were associated with higher depressive symptoms in adulthood. Childhood physical and mental health status, adulthood physical health and adulthood SES might be important mediators in the pathways of childhood familial environment affecting adulthood depressive symptoms.

Conclusions
This study is the first to explore the relationship of childhood familial environment and adulthood depression in China. The results indicate that parents’ physical and mental health, health behaviour and treatment equity among children a important predictors for adult depression.
In vitro bactericidal activity of amoxicillin combined with different cephalosporins against endocarditis-associated Enterococcus faecalis clinical isolates
Authors: Peiffer-Smadja Nathan , Guillotel Elena , Luque-Paz David , Maataoui Naouale , Lescure F -Xavier , Cattoir Vincent 
Published: August 2019

AbstractBackgroundThe combination of amoxicillin with cefazolin could be an interesting regimen for the empirical therapy of severe infective endocarditis, but its activity against enterococci is unknown.ObjectivesTo evaluate in vitro the bactericidal activity of the combination of amoxicillin with different cephalosporins including cefazolin.MethodsCombinations of amoxicillin (at MIC×¼) with cefazolin, cefotaxime, ceftriaxone, cefepime, ceftaroline or ceftobiprole (at the mean free plasma concentration) were studied using time–kill experiments for 10 endocarditis-associated Enterococcus faecalis strains and 2 reference strains.ResultsThe combinations amoxicillin/cefazolin, amoxicillin/cefotaxime, amoxicillin/ceftriaxone and amoxicillin/cefepime were synergistic at 12 and 24 h against 12/12 strains and amoxicillin/ceftobiprole and amoxicillin/ceftaroline against 10/12 strains. The combination amoxicillin/cefepime was bactericidal at 24 h against 9/12 strains, the combination amoxicillin/cefazolin against 8/12 strains, the combinations amoxicillin/ceftaroline, amoxicillin/cefotaxime and amoxicillin/ceftobiprole against 7/12 strains and the combination amoxicillin/ceftriaxone against 6/12 strains.ConclusionsThe combination amoxicillin/cefazolin is as synergistic and bactericidal in vitro as amoxicillin/cefotaxime or amoxicillin/ceftriaxone against E. faecalis.
Deep neural networks ensemble for detecting medication mentions in tweets
Authors: Weissenbacher Davy , Sarker Abeed , Klein Ari , O’Connor Karen , Magge Arjun , Gonzalez-Hernandez Graciela 
Published: August 2019

AbstractObjectiveTwitter posts are now recognized as an important source of patient-generated data, providing unique insights into population health. A fundamental step toward incorporating Twitter data in pharmacoepidemiologic research is to automatically recognize medication mentions in tweets. Given that lexical searches for medication names suffer from low recall due to misspellings or ambiguity with common words, we propose a more advanced method to recognize them.Materials and MethodsWe present Kusuri, an Ensemble Learning classifier able to identify tweets mentioning drug products and dietary supplements. Kusuri (薬, “medication” in Japanese) is composed of 2 modules: first, 4 different classifiers (lexicon based, spelling variant based, pattern based, and a weakly trained neural network) are applied in parallel to discover tweets potentially containing medication names; second, an ensemble of deep neural networks encoding morphological, semantic, and long-range dependencies of important words in the tweets makes the final decision.ResultsOn a class-balanced (50-50) corpus of 15 005 tweets, Kusuri demonstrated performances close to human annotators with an F1 score of 93.7%, the best score achieved thus far on this corpus. On a corpus made of all tweets posted by 112 Twitter users (98 959 tweets, with only 0.26% mentioning medications), Kusuri obtained an F1 score of 78.8%. To the best of our knowledge, Kusuri is the first system to achieve this score on such an extremely imbalanced dataset.ConclusionsThe system identifies tweets mentioning drug names with performance high enough to ensure its usefulness, and is ready to be integrated in pharmacovigilance, toxicovigilance, or more generally, public health pipelines that depend on medication name mentions.