bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-6 increase in CSF as additional diagnostic criteria for definite neuro-behcet disease
Authors: Kchaou Mariem , Bahrini Khadija , Belghith Meriam , Cherif Aroua , Maghrebi Olfa , Belal Samir , Barbouche Mohamed Ridha 
Published: February 2019

Abstract
Background: When the central nervous system (CNS) is the primary affected site in an initial attack of Behcet’s disease (BD), the differential diagnosis is particularly challenging. Some cases remain unclassified or qualified as probable Neuro-Behçet disease (NBD). Moreover, it was demonstrated that cytokines play a crucial role in the pathogenesis of NBD. We therefore studied peripheral and cerebrospinal inflammatory profile of these patients.
Methods: Twenty two parenchymal NBD patients diagnosed according to the international consensus recommendation criteria and classified into definite (d-NBD; n= 13) and probable (p-NBD ; n=9) were sampled at their first neurological symptoms and compared with healthy control subjects (n=10). Oligoclonal bands of IgG were detected by isoelectric focusing on agarose and immunoblotting of matched serum and Cerebrospinal fluid (CSF) sample pairs. Cytokines and transcription factors related to TH1, TH2, TH17 and T regulatory populations were studied by quantitative RT-PCR in the CSF.
Results: Oligoclonal bands (OCB) were present in only 1/22 patients. Two d-NBD patients had OCB in the CSF showing pattern 4. In NBD CSF samples, INF gamma, IL-17 and IL-10 expressions were significantly elevated compared with controls, however no difference in those cytokine expressions was observed between d-NBD compared to p-NBD. The most stricking finding was the significant increase of CSF IL-6 in d-NBD compared to p-NBD.
Conclusion:These results indicate the rare presence of OCB in parenchymal NBD patients. Additionally, CSF IL-6 could help us to identify definite NBD.
Keywords: Behçet’s disease, central nervous system, cerebrospinal fluid, cytokine.
An ethnography of policy: water reuse policy in Kenya
Authors: Wakhungu M. J. 
Published: February 2019

Abstract
Water scarcity and inadequate infrastructure for sanitation are two challenges that are emblematic to Kenya and other developing nations in Sub-Saharan Africa. Under such circumstances, water reuse has the potential to address these challenges but only under a favourable policy environment. In this paper, policy documents were considered as the ethnographic object to understand how people talk about water reuse in Kenya through policies, plans, regulations and guidelines. Using a general inductive approach to content analysis, the findings suggest that Kenya's policy on water reuse has progressed, especially in the recognition of the potential of reused water for addressing water scarcity, pollution, cleaner industrial production, food production, and climate change adaptation and mitigation. While many of the water reuse issues have been discussed under water and irrigation, environment and industrialization, other key sectors such as food and agriculture, housing, urban development and health remain silent on water reuse. Therefore, there is a need to take water reuse conversations beyond the water, environment, and industrialisation sectors if we are to address the water supply and wastewater management issues. Likewise, the study reminds us of the importance of foregrounding public perception and harmonized institutional arrangements in the success of water reuse in the country.
Representações sobre o patrimônio na imprensa escrita de Joinville – o caso do Bar Tigre e da Casa Amarela
Authors: Marques Dias Maria Cristina , Guedes Sandra P. L. Camargo 
Published: February 2019

Neste artigo propomos uma refl exão sobre representações sociais e imprensa, com base nas pesquisas sobre representações sociais de Serge Moscovici (2003), Roger Chartier (1988) e Sandra Jovchelovitch (2000) e sobre comunicação social de Pedrinho Guareschi (1991). A metodologia utilizada constou de pesquisa e análise das inserções publicadas nos jornais sobre o caso denominado popularmente de Bar Tigre e Casa Amarela, assim como de revisão bibliográfica, revisão da documentação oficial sobre o processo e realização de seis entrevistas orais com profissionais de imprensa e gestores do patrimônio. Observou-se como, com seu discurso, os veículos de comunicação contribuíram para a formação e a disseminação de representações sobre os imóveis. Nessas representações, patrimônio e história estavam relacionados, e as edificações foram apresentadas como sem valor histórico, “velharias” e obstáculos ao desenvolvimento proporcionado pelo supermercado que seria construído no local. Tal debate possibilitou a reflexão sobre temas amplos, como o que é patrimônio, sua ligação com a cidade e a necessidade de estabelecer novas regras para mediar essa relação.
Bosque Schmalz: uma herança contestada na cidade de Joinville (SC)
Authors: Radun Denis Fernando , Coelho Ilanil 
Published: February 2019

Buscando uma aproximação interdisciplinar entre os campos do Direito e do patrimônio cultural, o artigo discute o jogo de atribuição de valores que sustenta e legitima, do ponto de vista cultural e jurídico, alguns patrimônios culturais edificados em nossas cidades contemporâneas. Para tanto, procura refletir e problematizar o caso da patrimonialização do Bosque Schmalz, localizado na cidade de Joinville, Santa Catarina, e os pedidos pela sua despatrimonialização, dirigidos em momentos diversos ao Órgão Federal de Preservação. Além da bibliografia pertinente, utilizamos como principal fonte de investigação o processo administrativo do tombamento do bosque como patrimônio nacional, aberto em 1965. A nossa análise busca apontar para alguns dos desafios colocados pelas e para as políticas de proteção do patrimônio cultural na contemporaneidade brasileira, especialmente no que diz respeito ao instituto do tombamento.
Fomento à literatura: a formação do eu – práticas literárias em sistema prisional brasileiro
Authors: Giostri Alex 
Published: February 2019

Este artigo tem por finalidade apresentar ao leitor as atividades literáriasacontecidas na Penitenciária Industrial de Joinville pela óptica de seu idealizador e realizador. A prática acontece desde o ano de 2014 e já está em sua quinta publicação, sendo o foco principal dar voz aos apenados por meio das atividades de leitura e escrita. O artigo apresenta um panorama sobre o sistema carcerário nacional, além de falar sobre a redução de danos e mostrar em números e porcentagens as possíveis maneiras de fazer com que haja menos reincidências criminais por intermédio da formação de multiplicadores egressos do sistema e que diminua a criminalidade entre os jovens por meio de atividades de formação. Por fim, o artigo traz a pedagogia aplicada e expõe ao leitor uma experiência estadual que já foi premiada nacionalmente em 2017 e que se quer ampliar país afora.
Linear dimensional stability of irreversible hydrocolloids with and without disinfection at different storage times
Authors: Pinheiro Lidia Olga Bach , Ayala Alfonso Sanchez , Pomini Marcos Cezar , Cruz Vanessa Taborda da , Farias Ingrid Viel del , Samra Adriana Postiglione Buhrer 
Published: February 2019

Irreversible hydrocolloids have been used in dental practice for decades and their pouring time has been suggested to be as short as possible; however the latest generation of alginates exhibit better properties, which could influence the fidelity of the casts. Objective: To evaluate the linear dimensional stability of stone casts obtained using two irreversible hydrocolloid brands (Cavex ColorChange and Jeltrate) after disinfection. Material and methods: Samples were divided into 16 groups (n = 10) according to brand, storage time and disinfection. Impressions were taken of a metallic master model made of stainless steel with two abutments. Cast models were obtained using type IV gypsum, after disinfection with sodium hypochlorite at 1% or without any disinfection followed by storage for four different times (immediate pouring, and after 24, 72 or 120 hours storage after obtaining the impressions) and the models were measured with a digital caliper. Data were submitted to ANOVA 3-way followed by Tukey’s test (α < 0.05). Results: A statistically significant difference was detected with Jeltrate Plus after 72 and 120 hours in storage (with and without disinfection), as well as Cavex without disinfection. Differences were found for Cavex with disinfection/24 hours storage, when compared to immediate pouring (P < 0.05). The alginates presented similar behavior regarding disinfection for the same time (P > 0.05). Conclusion: Storage longer than 24 hours affects the fidelity of casts. Disinfection does not promote significant alteration at any of the experimental times with either material.
Noncoding RNAs and Intracerebral Hemorrhage
Authors: Li Lingzhi , Wang Pingping , Zhao Haiping , Luo Yumin 
Published: February 2019

Background & Objective:Intracerebral hemorrhage (ICH) is the most devastating subtype of stroke, for which there are few effective interventions. Computed tomography is accepted as the gold standard for diagnosis, whereas surgical evacuation is the main treatment for ICH. However, in emergency rooms, time is limited and information regarding a patient’s clinical status or tolerance is typically not available. Many studies over the last decade have investigated the fundamental mechanisms of ICH and especially hematoma, which not only cause physical damage but also release toxins that have detrimental effects. However, there remain many gaps in our understanding of ICH. Compared to ischemic stroke, there is little known about the ICH pathogenesis and treatment options, and few specific biomarkers are available for monitoring disease progression, which include hematoma enlargement and perihematoma edema. Noncoding RNAs (ncRNAs) are involved in various biological processes and are potential biomarkers and therapeutic tools in central nervous system diseases. Recent studies have examined the role of ncRNAs including microRNAs, long noncoding RNAs, and circular RNAs—the three main subgroups associated with stroke—in ICH models. A deeper understanding of the functions of ncRNAs in different biological processes can provide a basis for developing more effective therapeutic strategies to prevent neuronal damage following ICH. In clinical settings, ncRNAs can serve as biomarkers for predicting the degree of injury resulting from ICH.Conclusion:In this review, we discuss the current state of knowledge of the role of ncRNAs in ICH.
Exploring the Patent Landscape of RNAi-based Innovation for Plant Breeding
Authors: Frisio Dario Gianfranco , Ventura Vera 
Published: February 2019

Background:
RNA interference (RNAi) is an innovative technique for plant improvement
based on naturally occurring mechanisms which show great potential because of their high
specificity and possibility to be applied through innovative methods of topical application in
plants. This specific innovation sector is worth analysing from the economic perspective given the
great potentiality of RNAi-based plants and products to support modern agriculture in reaching the
goals for the improvement of agri-food chains global sustainability. This paper aims to evaluate
the global landscape of RNAi innovation by analysing patent data as indicators of innovation output.

Methods:
We revised all patents relating to RNAi in plants based on a dataset of roughly seven
thousand patent families. The analysis classified inventions according to a set of variables able to
characterise the dynamics of innovation (i.e. public/private ownership, type of plants involved,
main traits) while the use of concentration indices provided insights into the evolution of this sector.

Results:
Results revealed that RNAi is a technique with promising future applications, able to
provide solutions to a great variety of agricultural issues and principally developed by the US and
Chinese applicants, whereas European innovation capacity in this field appears to be limited.

Conclusion:
The innovation landscape of plant breeding is rapidly evolving and RNAi technique
is probably going to play a major role in this field.
O estado do conhecimento sobre estágio supervisionado nas licenciaturas
Authors: Gabriel Fábio Antonio , Pereira Ana Lúcia , De Jesuz Danilo Augusto Ferreira 
Published: February 2019

O Estágio Supervisionado compõe uma das etapas na formação inicial do professor, como um momento único e importante, uma vez que enseja ao futuro professor o contato com a realidade escolar a fim de que o estagiário, futuro professor, perceba como serão suas atividades como docente. O presente artigo, portanto, tem como objetivo realizar um levantamento do estado do conhecimento sobre Estágio Supervisionado nos cursos de licenciaturas. A metodologia da pesquisa utilizada foi a pesquisa bibliográfica e do tipo estado do conhecimento. Os resultados permitem apontar que o Estágio Supervisionado é o momento oportuno do acadêmico assimilar saberes da experiência para, paulatinamente, construir sua identidade profissional e, desse modo, poder ter condições de ser um bom professor quando chegar seu momento de atuar profissionalmente.
Ensino de História e pensamento decolonial em processos de identificação quilombola
Authors: Lucini Marizete , Santos Andréia Teixeira dos 
Published: February 2019

Este artigo propõe refletir sobre o Ensino de História e o pensamento decolonial na análise de processos de identificação étnico-racial em comunidades quilombolas, aqui compreendidos como espaços políticos de resistência às práticas sociais colonizadoras da memória ancestral. A discussão origina-se de pesquisa com abordagem qualitativa, do tipo estudo de caso, em desenvolvimento na Escola Estadual Quilombola Gilberto Amado, sobre os processos de identificação quilombola em comunidade remanescente de quilombo urbano Porto D’Areia – Estância/Sergipe. O aporte teórico ancora-se no pensamento decolonial ao questionar todas as formas de colonização do saber, do poder e do ser. Espera-se contribuir para a superação do olhar colonizador que inferioriza o negro e interfere no processo de reconhecimento da identidade quilombola.
ANEMIA FERROPRIVA ASSOCIADA À INFECÇÃO POR ANCILOSTOMÍDEO
Authors: Teles Marcelo Felipe Pereira , Gomes Sandra Lima Rosa 
Published: February 2019

Anemia ferropriva é um dos distúrbios mais frequentes em países desenvolvidos e em desenvolvimento, classificada pela Organização Mundial de Saúde (OMS) como uma condição na qual o conteúdo de hemoglobina do sangue apresenta-se abaixo dos valores de referência considerados normais para a idade, sexo e estado fisiológico. A anemia por deficiência de ferro é considerada um transtorno nutricional que atinge principalmente o desenvolvimento de crianças entre 0 e 5 anos, idosos e mulheres, principalmente gestantes, causada por vários fatores, entre eles alguns parasitas intestinais como os ancilostomídeos. Esses parasitas podem reduzir em até 20% do ferro ingerido na dieta, o que pode resultar em anemia por deficiência de ferro caracterizando um problema de saúde pública que afeta as comunidades mais pobres e desfavorecidas, especialmente em áreas rurais em que as pessoas possuem o hábito de andar descalças. Diante disso, este estudo tem como objetivo descrever os principais fatores associados à infecção por ancilostomídeo, que contribuem para a instalação do quadro de anemia ferropriva. Foi possível observar que a infecção por ancilostomídeo está diretamente relacionada à anemia ferropriva devido à lesão intestinal causada por esse parasita. Sendo assim, a adoção de medidas preventivas e o diagnóstico precoce da infecção são importantes para o controle, tratamento e redução da incidência da doença.
Can Simple Metaphors Be Used as Decision Aids to Promote Professional Skepticism?
Authors: Durkin Mary P. , Rose Jacob M. , Thibodeau Jay C. 
Published: February 2019

ABSTRACT
This study examines the potential for metaphorical priming to promote professional skepticism. Results of an experiment with 99 senior auditors from two Big 4 audit firms indicate that reading metaphors that are entirely unrelated to audit evidence can promote professional skepticism and influence auditors' judgments. Relative to auditor participants who did not read a metaphor, participants who read a metaphor related to concerns about the honesty of the sources of information (client-skeptical metaphor) or concerns about one's own ability to detect problems (self-skeptical metaphor) assessed higher levels of fraud risk. These auditors also perceived that fraud-based explanations were more likely to cause fluctuations in client ratios. Importantly, metaphorical primes improved auditors' fraud-related actions and caused them to focus on issues that were the most likely explanations for the audit evidence. Results suggest that metaphorical priming may represent a powerful and efficient tool for promoting high-quality and professionally skeptical judgments.
Occlusion of the corpus cavernosum penis in bulls intended for estrus detection: 18 cases (2002–2016)
Authors: Davern Alec J. , Baird Aubrey N. , Koziol Jennifer H. 
Published: February 2019

Abstract
OBJECTIVE To report surgical and long-term postoperative outcomes of bulls undergoing surgical occlusion of the corpus cavernosum penis (CCP) by acrylic injection and epididymectomy with or without penile fixation as preparation for use in estrus detection.
DESIGN Retrospective case series.
ANIMALS 18 client-owned bulls.
PROCEDURES Medical records of bulls that underwent CCP occlusion between December 2002 and March 2016 were identified. Signalment, surgical data, and reported complications were recorded. Long-term (> 6 months after surgery) follow-up data were obtained from medical records or by telephone interview of bull owners with a questionnaire focused on postoperative outcome, use of the bull for estrus detection, and overall satisfaction with the procedure.
RESULTS Intraoperative complications included difficulty isolating the penis, polymerization of the acrylic prior to injection, incomplete anesthesia of the surgical site, and fecal contamination of the site. Deposition of acrylic in an improper location led to urethral obstruction and euthanasia of 1 bull; another developed an abscess that was treated successfully. One bull was euthanized because of orchitis. Most (15/18) bulls were used for estrus detection (mean duration, 17.9 months). Libido was considered good or very good for 14 of 15 bulls; 1 was culled for loss of libido after 14 months. Ten of 12 bulls were reportedly unable to protrude the penis; 2 had or developed partial protrusion ability. Overall client satisfaction was high.
CONCLUSIONS AND CLINICAL RELEVANCE In this population of healthy young bulls, CCP occlusion was generally well tolerated. Most bulls that underwent CCP occlusion (and epididymectomy with or without penile fixation) had adequate libido, and none were reported able to achieve intromission.
Behavioral health of US military veterinary personnel deployed to Afghanistan
Authors: Penix Elizabeth A. , Whitmer Deborah L. , Thomas Jeffrey L. , Wilk Joshua E. , Adler Amy B. 
Published: February 2019

Abstract
OBJECTIVE To compare symptoms of compromised behavioral health (BH symptoms) and factors protecting against those symptoms (protective factors) in military veterinary and nonveterinary health-care personnel deployed to Afghanistan.
DESIGN Cross-sectional survey.
SAMPLE 237 deployed military health-care personnel (21 veterinary and 216 nonveterinary).
PROCEDURES Surveys were administered to participants during combat deployment in Afghanistan in 2013 to collect information on BH symptoms and protective factors. Data were compared between veterinary and nonveterinary health-care personnel by use of regression models controlling for demographic characteristics and deployment experiences. Partial correlations were computed to assess relationships between protective factors and BH symptoms, controlling for personnel type.
RESULTS Less than 15% of veterinary and nonveterinary health-care personnel were at risk for suicidal ideation, major depressive disorder, generalized anxiety disorder, and posttraumatic stress disorder. After adjusting for covariates, both personnel types had similar levels of depression, posttraumatic stress disorder, and anxiety symptoms; however, veterinary personnel reported more distressing secondary traumatic stress symptoms and a greater number of anger reactions. Self-care, team support, and perceived supportive leadership were inversely associated with BH symptoms regardless of personnel type. Veterinary personnel engaged in less self-care, provided less team care, and rated leadership behaviors less positively than nonveterinary health-care personnel.
CONCLUSIONS AND CLINICAL RELEVANCE Compared with nonveterinary health-care personnel, deployed veterinary personnel were at greater risk of generalized anxiety disorder and reported more secondary traumatic stress and anger reactions, but were less likely to be engaged in and exposed to protective factors. Interventions designed to promote self-care and team support for veterinary personnel and their leaders may reduce the occupational risk of BH symptoms in deployment and perhaps other settings.
The level of moral competences of pre-service PE teachers – a reason to worry?
Authors: Bronikowska Małgorzata , Korcz Agata 
Published: February 2019

Summary
Study aim: The main purpose of this study was to examine the level of moral competences of 437 pre-service physical educa­tion (PE) university students. It was also designed to evaluate the level of moral competency and the correlations with factors (i.e. Parents, Religion, School education, PE teacher, Sport coach, Studies, Media and Peers) potentially influencing moral development in pre-service PE teachers. Material and methods: The study included data collected in 2017 from 216 male and 221 female students aged 21.5 ± 1.85 from the faculty of Physical Education in Poznań, Poland. The students were categorised into three levels of moral competences, after which possible correlations between the factors influencing moral development were examined. The Moral Competence Test (MCT) survey was used to measure the ability to rate arguments by their moral quality. Participants were requested to confront two moral dilemmas and agree or disagree with the statements which were presented to them. Results: The results suggest that a vast majority of students (78.7%) present a very low level of moral competences, and with regard to the factors influencing moral development, the lowest value was attributed to PE teachers. Moderate positive correla­tions were found between School education and PE teacher, and between Sport coach and PE teacher. Conclusions: The findings indicate the need for more attention to be paid to moral education in teacher training in PE.