bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel multiplex assay for profiling influenza antibodies in breast milk and serum of mother-infant pairs
Authors: Järvinen Kirsi M. , Wang Jiong , Seppo Antti E. , Zand Martin 
Published: March 2019

Background: During early life, systemic protection to influenza is passively provided by transplacental transfer of IgG antibodies and oral and gastrointestinal mucosal protection via breast milk (BM) containing predominantly IgA. Immune imprinting, influenced by initial exposure of the infant immune system to influenza, has recently been recognized as an important determinant of future influenza immune responses. Methods: We utilized stored frozen BM from a prospective birth cohort to assess immune factors in human milk. The earliest available BM and a paired, timed serum sample was assessed from each of 7 mothers. Paired infant serum samples were assayed at up to three time points during the first 12 months of life, one prior to assumed disappearance of transplacentally transferred IgG, and one after. We utilized a novel multiplex assay to assess mothers’ and infants’ IgG and IgA antibodies in serum to a panel of 30 individual recombinant hemagglutinin (rHA) proteins of influenza virus strains and chimeric rHAs. We also characterized IgA and IgG antibody levels in breast milk which provide mucosal protection. Results: Our pilot results, analyzing a small number of samples demonstrate the feasibility of this method for studying paired maternal-infant IgG and IgA anti-influenza immunity patterns. Unlike IgG antibodies, breast milk influenza virus HA-specific IgA antibody levels and patterns were mostly discordant compared to serum. As expected, there was a steady decay of infant influenza specific IgG levels by 6 to 8 months of age, which was not, however, comparable in all infants. In contrast, most of the infants showed an increase in IgA responses throughout the first year of life Conclusions: This new analytical method can be applied in a larger study to understand the impact of maternal imprinting on influenza immunity.
Safe investigation of isolated change in bowel habit with a flexible sigmoidoscopy? A systematic review and meta-analysis
Authors: Herrod PJJ , Boyd-Carson H , Doleman B , Blackwell JEM , Hardy EJO , Harper F , Lund JN 
Published: March 2019

Introduction Public awareness campaigns have led to increasing referrals of patients to colorectal surgery for possible cancer. Change in bowel habit, is traditionally described as a symptom of a left sided bowel cancer. If this is the case in practice, it raises the potentially attractive option of investigating such patients with flexible sigmoidoscopy only. This study sought to systematically review the literature describing tumour location of patients with bowel cancer presenting with left-sided symptoms to establish the safety of potential investigation of these patients with flexible sigmoidoscopy alone. Methods A systematic review of studies reporting both the presenting symptoms of patients with bowel cancer and the location of their cancer in the bowel was prospectively registered (CRD42017072492). MEDLINE, EMBASE and CENTRAL were searched with no date or language restriction. Results Seven studies were included. Isolated change in bowel habit (with or without rectal bleeding) was a presenting symptom of 73% (95% CI 41–96%, I2 = 99%) of left-sided cancers but also in 13% (95% CI 2–30%, I2 = 96%) of right-sided cancers. In all patients with cancer who presented with isolated change in bowel habit (with or without rectal bleeding), the cancer was right sided in 8% (95% CI 4–12%, I2 = 69%). Conclusions There is a higher than expected risk that if a cancer is diagnosed in a patient presenting with either an isolated change in bowel habit or a combination of change in bowel habit with rectal bleeding, the cancer may be right sided.
Commutability of a Whole-Blood External Quality Assessment Material for Point-of-Care C-Reactive Protein, Glucose, and Hemoglobin Testing
Authors: Bukve Tone , Sandberg Sverre , Vie Wenche S , Sølvik Una , Christensen Nina G , Stavelin Anne 
Published: March 2019

AbstractBACKGROUNDThe optimal situation in external quality assessment (EQA) is to use commutable materials. No previous study has examined the commutability of a whole-blood material for point-of-care (POC) testing. The aim of this study was to determine the commutability of the Norwegian Quality Improvement of Laboratory Examinations (Noklus) organization's “in-house” whole-blood EQA material for C-reactive protein (CRP), glucose, and hemoglobin for frequently used POC instruments in Norway and to determine the possibility of using a common target value for each analyte.METHODSThe study was performed according to the Clinical and Laboratory Standards Institute guidelines. The EQA material was pooled stabilized EDTA venous whole-blood containing different concentrations of the analytes. The EQA material and native routine patient samples were analyzed using 17 POC and 3 hospital instruments. The commutability was assessed using Deming regression analysis with 95% prediction intervals for each instrument comparison.RESULTSThe EQA material was commutable for all CRP and hemoglobin POC instruments, whereas for glucose the material was commutable for all POC instruments at the lowest concentration analyzed [126.0 mg/dL (7.0 mmol/L)] and for 3 POC instruments at all of the concentrations analyzed.CONCLUSIONSNoklus EQA participants using CRP and hemoglobin POC instruments now receive results that are compared with a reference target value, whereas the results for participants using glucose POC instruments are still compared with method-specific target values. Systematic deviations from a reference target value for the commutable glucose POC instruments can be calculated, and this additional information can now be offered to these participants and to the manufacturers.
Managing Neglected Burn Wound with Exposed Upper Tibia Using Multiple Modalities
Authors: Kalangi Cherry G , Hariyanto Agus , Oley Mendy Hatibie 
Published: March 2019

Background: Deep burn wound with exposed underlying structures such as muscle or moreover in this case, bone, may increase morbidity in the terms of infection. Therefore careful planning of reconstruction is needed.
Patient and Method: We report one case of neglected burn wound with exposed tibia and muscle contracture on bilateral knee joint that was reconstructed in our Plastic Surgery Division of Prof RD Kandou Hospital. Data was taken from medical and surgery record.
Result: We managed the muscle contracture of the left knee joint by sedated gradual stretching and splinting. We also utilized hyperbaric treatment in order to maximize granulation process. A medial gastrocnemius muscle flap followed by split thickness skin graft is used to reconstruct the missing tissue at upper tibia, and another split thickness skin graft to cover another wound at opposite upper leg. The result was satisfying without any complication.
Conclusion: In managing a neglected burn wound with bone exposed and muscle contracture, it is compulsory to have a careful reconstruction planning. Our objectives are to release the muscle contracture and to provide an adequate coverage to the bone-exposed wound by using many modalities we have.
Antimicrobial effect of methylene blue formulations with oxygen carrier at different pHs: preliminary study
Authors: Knorst Jessica Klöckner , Barriquello Gabriela Scarton , Villetti Marcos Antônio , Santos Roberto Christ Vianna , Kantorski Karla Zanini 
Published: March 2019

Objective: Evaluate methylene blue (MB) formulations containing oxygen carrier at different pHs in antimicrobial photodynamic therapy (aPDT). Material and Methods: Biofilms of Pseudomonas aeruginosa PA01 formed over acrylics specimens during five days were treated with aPDT using different formulations: MB/pH 7.4; MB/pH 5.6; MB/carrier pH 7.4; MB/carrier pH 5.6. Biofilms not exposed to treatment were used as a control. Blind examiner for the experimental groups performed the counting of colonies per ml suspension (CFU/ml). Two-way ANOVA was used to determine the effect of factors solvent (carrier vs water) and pH (7.4 vs 5.6). One-way ANOVA and post-hoc Tukey’s test was used to evaluate differences among the five groups (control; MB/carrier pH 7.4; MB pH 7.4; MB/carrier pH 5.6; MB pH 5.6). The Statistics 8.0 software was used (P<0.05). Results: All of photodynamic therapy groups showed significant reduction in P. aeruginosa compared to the control group. The solvent factor was not significant (P=0.18), while the pH factor presented statistical significance (P=0.01). When the carrier was used, MB formulation at pH 7.4 presented a statistically greater reduction of P. aeruginosa than the formulation with pH 5.6. Conclusion: The PDT using methylene blue formulations with oxygen carrier demonstrated potential for the treatment of localized infections by P. aeruginosa. MB formulations with oxygen carrier and pH 7.4 resulted in higher antimicrobial effect and should be considered for future studies with multispecies biofilms. KeywordsAntimicrobial photodynamic therapy; biofilm; laser; Pseudomonas aeruginosa.
Minimally invasive aesthetic rehabilitation in composite resin: report of two clinical cases
Authors: Pedreira Priscila Regis Matos , Damasceno Janaina , Pierote Josué , Dressano Diogo , Marchi Giselle Maria 
Published: March 2019

Patient demand looking for the perfect smile has been steadily growing in the last few years. Thus, these two case reports discuss some ultra-conservatives approach to achieve good esthetic results. In the first case the clinical protocol of a restorative approach is described, the cosmetic remodeling of the teeth and in the second case, the replacement of extensive unsatisfactory composite restorations. The treatment planning was based on diagnostic waxing and the making of mock-up in both cases. Teeth bleaching were also performed before restoration. To conclude, these conservative relative therapies with composite resin restorations provide an ultra-minimally invasive protocol with excellent esthetic appearances and fuction, especially for young people. KeywordsDental esthetics; Composite resins; Smiling; Restoration.
Use of Cone Beam Computed Tomography to Identify the Morphology of Maxillary and Mandibular Premolars in Chennai Population
Authors: Rajakeerthi Rajamohan , Nivedhitha Malli Suresh Babu 
Published: March 2019

Objective: The complex root canal anatomy is inherently colonised by microbial flora. Endodontic treatment success is always related to adequate disinfection of the root canal space, which ultimately affects the treatment outcome. A thorough understanding of the external and internal root canal anatomy by using adequately imaging modalities is essential before planning any treatment. The aim of this study was to investigate the number and morphology of the root canals of maxillary and mandibular premolars in Chennai population. Material and Methods: Full-size cone-beam computed tomographic images were randomly collected from 100 patients, resulting in a total of 200 first and 200 second maxillary premolars as well as 200 first and 200 second mandibular premolars. All the eight premolars were analysed in single patients, who underwent cone-beam computed tomography scanning during pre-operative assessment (before implant surgery, orthodontic treatment, diagnosis of dental-alveolar trauma or difficult root canal treatment). Total number of roots and root canals, frequency and correlations between men and women were recorded and statistically analysed by using chi-square tests. The root canal configurations were rated according to the Vertucci’s classification. Results: In the maxillary first premolar group (n = 200), 36.3% had 1 root, 56.7% had 2 roots and 7.0% had 3 roots, with most exhibiting a type IV canal configuration. In the maxillary second premolar group (n = 200), 60% had 1 root, 29.8% had 2 roots and 10.2% had 3 roots, with the majority of single-rooted second premolars exhibiting a type I canal configuration. In the mandibular first premolar group (n = 200), 80.5% had 1 root, 9.8% had 2 roots and 5% had 3 roots. In the mandibular second premolar group (n=200), 90.1% had 1 root, 6.4% had 2 roots and 3.5 % had 3 roots, with most exhibiting a type I canal configuration. No statistical correlation was found between number of roots, gender and tooth position. Conclusion: This cone-beam computed tomographic study confirmed previous anatomical and morphological investigations. Therefore, the possibility of additional root canals should be considered when treating premolars. Keywords: Cone-beam computed tomography; Mandibular; Maxillary; Premolar; Root canal; Morphology.
Uma reverência à Meta-história e a Hayden White: o passado como sátira irônica e liberal em Sérgio Buarque de Holanda
Authors: Bentivoglio Julio 
Published: March 2019

Este texto se destina a analisar a poética e o estilo historiográfico presente em Raízes do Brasil, obra clássica de Sérgio Buarque de Holanda, em particular no capítulo “Trabalho & aventura”, à luz da tropologia proposta por Hayden White em seu Meta-história. Ele discute o acento satírico, liberal e irônico da narrativa de Holanda em sua representação histórica do passado colonial brasileiro. Trata-se de um artigo que se integra um projeto maior focado na imaginação histórica brasileira nos anos 1930 e 1940, do qual já foi produzido um primeiro ensaio sobre Caio Prado Júnior, publicado em 2005 na revista Storia della Storiografia.
palavras-chave: Historiografia brasileira; Sérgio Buarque de Holanda; Meta-história.
El mundo natural real y mítico en la antigua Grecia: ¿un sentido medioambiental secundario?
Authors: Saco Julio López 
Published: March 2019

La presencia de elementos naturales y su valoración en la literatura y las representaciones plásticas (relieves, pintura vascular) no es abundante en un ámbito, el de la Grecia de la antigüedad, en el que la figura humana y la antropomorfización se configuraron como regla fundamental. Sin embargo, a pesar de la relativa escasez de motivos naturales, su significación en el marco de la imaginación mítica helena es relevante, y no solamente como motivo subyacente o complementario. En este trabajo intentaremos revelar, a través del comentario de fuentes textuales y el análisis de algunas representaciones, sobre todo vasculares, la especial interdependencia entre el ser humano y el medioambiente, así como el valor mítico-simbólico de paisajes naturales, agrestes o cultivados, además de los elementos propios del mismo, como el agua, la vegetación, sobre todo árboles, o accidentes del relieve, como las montañas.
palabras clave: mito; arte; naturaleza.
Clube da Esquina versus Tropicalismo: conflitos simbólicos na MPB
Authors: Diniz Sheyla Castro 
Published: March 2019

Em 2018, o antológico álbum Clube da Esquina completou 46 anos. Seus autores, Milton Nascimento e Lô Borges, não imaginavam que o disco duplo lançado pela EMI-Odeon em 1972 se tornaria nome de um movimento musical, tal como a crítica jornalística e parte da crítica acadêmica trataram de assim legitimar a ampla turma de compositores, músicos e amigos reunida em torno de Milton. Uma das mais criativas e versáteis “formações culturais” atuantes na década de 1970, o Clube da Esquina ocupa hoje um lugar de destaque na MPB – para não falar do já conquistado prestígio internacional. Em meio aos processos que conduziram ao seu reconhecimento, um assunto geralmente ignorado pela bibliografia consistiu no fato de que o Tropicalismo foi vetor de alguns conflitos simbólicos que, neste artigo, busco trazer à tona e problematizar.
palavras-chave: Clube da Esquina; Tropicalismo; conflitos simbólicos.
Versão portuguesa do Cyber Dating Abuse Questionaire (CDAQ) – Questionário sobre Ciberabuso no Namoro (CibAN): Adaptação e propriedades psicométricas
Authors: Caridade Sónia Maria , Braga Teresa 
Published: March 2019

Algumas manifestações de violência no namoro ocorrem através do uso das novas tecnologias, pelo que importa investigar esta tipologia de abuso apelidada internacionalmente de cyber dating abuse. O presente estudo procurou traduzir e adaptar, para a população portuguesa, o Cyber Dating Abuse Questionaire (CDAQ; Borrajo, Gámez-Guadix, Pereda, & Calvete, 2015), estudando as suas propriedades psicométricas. A versão portuguesa foi administrada a uma amostra de 272 estudantes, a grande maioria (87%) de sexo feminino e com uma média de idades de 28.41 (DP=7.02). A análise fatorial confirmatória revelou bons índices de ajustamento, permitindo confirmar o modelo fatorial do instrumento original constituído por quatro fatores correlacionados, dois relativos à vitimação por agressão direta e controlo e dois à perpetração dessas mesmas tipologias de violência. Adicionalmente, todos os fatores revelaram boa consistência interna. Ainda que os indicadores de prevalência de vitimação e perpetração por controlo (58.8% vs. 63.2%, respetivamente) se tenham revelado mais preponderantes comparativamente aos de vitimação e perpetração por agressão direta (18% vs. 14.7%), foi possível confirmar que estes dois tipos de ciberabuso íntimo constituem comportamentos entre os jovens portugueses estudantes universitários envolvidos/as em relações íntimas. As implicações práticas e empíricas futuras deste estudo são objeto de discussão neste trabalho.
A pilot study of the Portuguese version of the Voices Acceptance and Action Scale: Psychometric properties in a clinical sample with psychosis-spectrum disorders
Authors: Martins Maria João , Castilho Paula , Macedo António , Pereira Ana Telma , Vagos Paula , Carvalho Diana , Pascoal Ana Carolina , Carvalho Célia Barreto 
Published: March 2019

Tendo em conta o interesse recente nas intervenções baseadas na aceitação para a psicose, tem sido recomendado que os mecanismos de coping com as vozes, nomeadamente a aceitação experiencial, sejam avaliados no contexto clínico e de investigação. A Escala de Aceitação e Ação em relação às Vozes (VAAS-12) é um instrumento de autorresposta especificamente desenvolvido para avaliar as crenças baseadas na aceitação ou na ação em relação às alucinações auditivo-verbais. O presente estudo tem como objetivo a tradução, adaptação e estudo das propriedades psicométricas da versão portuguesa da VAAS-12 numa amostra clínica dentro do espectro das perturbações psicóticas. A VAAS-12 foi traduzida e adaptada para Português. As suas propriedades psicométricas foram posteriormente estudadas numa amostra de cinquenta e quatro participantes do sexo masculino, maioritariamente solteiros, desempregados e com uma experiência de ouvir vozes na última semana. Foram realizadas análises fatoriais confirmatórias para as estruturas de um e dois fatores sugeridas em estudos prévios, sendo que ambas apresentaram índices de ajustamento inaceitáveis. A análise fatorial exploratória realizada posteriormente revelou uma estrutura alternativa de dois fatores (“Não interferência e ação” e “Aceitação e Funcionamento”) que obteve ajustamento adequado. Foi encontrada adequada consistência interna e validade de constructo, tendo sido encontradas associações negativas com a perceção das vozes como hostis-dominantes e resistência em relação às vozes. A VAAS-12 parece ser adequada para uso em contexto clínico e de investigação, embora mais estudos sejam necessários particularmente no que diz respeito à subescala “Aceitação e Funcionamento”.
Associações entre o uso do script de base segura e o conhecimento das emoções em crianças de idade pré-escolar
Authors: Fernandes Carla , Verissimo Manuela , Fernandes Marilia , Antunes Marta , Santos António J. , Vaughn Brian E. 
Published: March 2019

As associações entre a segurança da vinculação e múltiplos aspetos do desenvolvimento emocional têm sido estudadas durante várias décadas. Embora estes estudos sejam válidos, algumas respostas relacionadas com as representações de vinculação e o conhecimento emocional continuam em aberto. Participaram neste estudo crianças de idade pré-escolar (N=40). Utilizámos o Attachment Story Completion Task como medida de vinculação das crianças, com as representações a serem avaliadas enquanto acesso e uso do script de base segura (SBS) para organizar as narrativas de vinculação das crianças. O conhecimento emocional foi avaliado com recurso ao Teste do Conhecimento das Emoções. O nosso principal objetivo era demonstrar que o SBS se comporta como uma típica medida das representações de vinculação, no que diz respeito à sua associação com a compreensão das emoções por parte das crianças. Os resultados sugerem que as crianças com histórias de vinculação segura tendem a ter uma maior base de conhecimento emocional. A medida de SBS comportou-se de forma semelhante a outras medidas de segurança de vinculação, sugerindo a sua validade enquanto medida de representações de vinculação durante a infância.
A contemporary vision of project success criteria
Authors: Castro Marcela Souto , Bahli Bouchaib , Farias Filho José Rodrigues , Barcaui Andre 
Published: March 2019

Goal: The objective of this research is to provide researchers and project management professionals with a contemporary view of the measurement of project success.
Design/Methodology/Approach: After a dense literature review, a research-based study analyzes the project success criteria perspectives of 264 Brazilian project managers and provides a ranking of the most widely used measures in practice in Brazilian organizations.
Results: The study analyzes contemporary literature on project success criteria and discusses overlaps and trends. One of the important findings of this research is the identification of mismatches between academic perspectives and those of project managers in regard to project success as well as real success criteria used in organizations.
Limitations of the investigation: As the sample covered was comprised exclusively of Brazilian project managers, cross-cultural success criteria research is, therefore, encouraged.
Practical implications: The proposed performance criteria can be used in future research and for professional proposes in success criteria assessment.
Originality/Value: Given the diversity of success criteria measures, authors can have difficulty in finding the one that better fits their needs; alternatively, they can create their own scale. The reliability of several studies can be questioned due to their subjectivity and, in some cases, weakly defined measures. The present study can therefore provide project professionals with guidelines for success assessment that make measuring and comparing different projects possible.
Insurance-markets Equilibrium with Sequential Non-convex Straight-time and Over-time Labor Supply
Authors: VASILEV Aleksander 
Published: March 2019

This note describes the lottery - and insurance-market equilibrium in an economy with non-convex straight-time and overtime employment. In contrast to Hansen and Sargent (1988), the overtime-decision is a sequential one. This requires two separate insurance market to operate, one for straight-time work, and one for overtime. In addition, given that the labor choice for regular and overtime hours is made in succession, the insurance market for overtime needs to open once the insurance market has closed. This segmentation and sequentiality of insurance markets operation is a new result in the literature and a direct consequence of the sequential nature of the overtime labor decision.