bluuebunny/crossref_metadata_2025_split huggingface dataset:
The TrkB‐T1 receptor mediates BDNF‐induced migration of aged cardiac microvascular endothelial cells by recruiting Willin
Authors: Wang Zhefeng , Chen Yilin , Chen Xuwei , Zheng Xin , Xu Ganlin , Yuan Ziqiang , Zhao Hui , Chen Wensheng , Li Lilin , Zheng Nianjue , Shen Xiaotao , Li Yanmei , Qi Xufeng , Cai Dongqing 
Published: January 2019

AbstractThe mechanism of age‐related decline in the angiogenic potential of the myocardium is not yet fully understood. Our previous report revealed that the aging of cardiac microvascular endothelial cells (CMECs) led to changes in their expression of receptor Trk isoforms: among the three isoforms (TrkB‐FL, TrkB‐T1 and TrkB‐T2), only the truncated TrkB‐T1 isoform continued to be expressed in aged CMECs, which led to decreased migration of CMECs in aging hearts. Thus far, how BDNF induces signalling through the truncated TrkB‐T1 isoform in aged CMECs remains unclear. Here, we first demonstrated that aged CMECs utilize BDNF–TrkB‐T1 signalling to recruit Willin as a downstream effector to further activate the Hippo pathway, which then promotes migration. These findings suggest that the aging process shifts the phenotype of aged CMECs that express TrkB‐T1 receptors by transducing BDNF signals via the BDNF–TrkB‐T1–Willin–Hippo pathway and that this change might be an important mechanism and therapeutic target of the dysfunctional cardiac angiogenesis observed in aged hearts.
Eicosanoid mediator profiles in different phenotypes of nonsteroidal anti‐inflammatory drug‐induced urticaria
Authors: Doña Inmaculada , Jurado‐Escobar Raquel , Perkins James R. , Ayuso Pedro , Plaza‐Serón María Carmen , Pérez‐Sánchez Natalia , Campo Paloma , Bogas‐Herrera Gador , Bartra Joan , Torres María José , Sanak Marek , Cornejo‐García José Antonio 
Published: January 2019

AbstractBackgroundThe role of arachidonic acid metabolites in NSAID‐induced hypersensitivity has been studied in depth for NSAID‐exacerbated respiratory disease (NERD) and NSAID‐exacerbated cutaneous disease (NECD). However, no information is available for NSAID‐induced urticarial/angioedema (NIUA), despite it being the most frequent clinical entity induced by NSAID hypersensitivity. We evaluated changes in leukotriene and prostaglandin metabolites for NIUA patients, using patients with NECD and single‐NSAID‐induced urticaria/angioedema or anaphylaxis (SNIUAA) for comparison.MethodsUrine samples were taken from patients with confirmed NSAID‐induced urticaria and healthy controls, at baseline and at various time intervals after ASA administration. Eicosanoid measurement was performed using high‐performance liquid chromatography‐tandem mass spectrometry and gas chromatography‐mass spectrometry.ResultsNo differences were found between groups at baseline. Following ASA administration, LTE4 and 9α,11β‐PGF2 levels were increased in both NIUA and NECD patients compared to baseline, rising initially, before decreasing toward initial levels. In addition, the levels of these metabolites were higher in NIUA and NECD when compared with the SNIUAA and control groups after ASA administration. No changes were found with respect to baseline values for SNIUAA and control groups.ConclusionsWe present for the first time data regarding the role of COX‐1 inhibition in NIUA. Patients with this entity show a similar pattern eicosanoid levels following ASA challenge to those with NECD. Further studies will help ascertain the cell populations involved and the underlying molecular mechanisms.
Effects of the nitric oxide synthase inhibitor ronopterin (VAS203) on renal function in healthy volunteers
Authors: Ott Christian , Bosch Agnes , Winzer Nicole , Friedrich Stephanie , Schinzel Reinhard , Tegtmeier Frank , Schmieder Roland E. 
Published: January 2019

AimsReduced nitric oxide (NO) availability may adversely affect renal perfusion and glomerular filtration. The aim of the present study was to characterize in detail the pharmacological effects of VAS203, an inhibitor of NO synthase, on renal haemodynamics in humans.MethodsThis double‐blind, randomized, placebo‐controlled, cross‐over phase‐I‐study comprised 18 healthy men. Renal haemodynamics were assessed with constant‐infusion input‐clearance technique with p‐aminohippurate and inulin for renal plasma flow (RPF) and glomerular filtration rate (GFR), respectively. After baseline measurement, a constant infusion of the tetrahydrobiopterin analogue ronopterin (VAS203, total 10 mg/kg body weight) or placebo was administered at random order for 6 hours additionally. After a wash‐out phase of 28 days, the second course was applied. In parallel, markers of early kidney injury and renal function were assessed repeatedly up to 48 hours after starting VAS203/placebo‐infusion.ResultsVAS203‐infusion resulted in a significant decrease of RPF (P < .0001) and GFR (P < .001) compared to placebo, but magnitude was within the physiological range. RPF and GFR recovered partly 2 hours after end of VAS203‐infusion and was normal at beginning of the second infusion period. Compared to placebo, preglomerular resistance (P < .0001), and to lesser extent postglomerular resistance (P < .0001) increased, resulting in a decrease of intraglomerular pressure (P < .01). No treatment related effect on markers of early kidney injury, and on renal function (P for all >.20) have been observed.ConclusionsOur phase‐I‐study in healthy humans indicates that VAS203 (10 mg/kg body weight) reduces renal perfusion and glomerular function within the physiological range mainly due to vasoconstriction at the preglomerular site.
Combined comparative molecular field analysis, comparative molecular similarity indices analysis, molecular docking and molecular dynamics studies of histone deacetylase 6 inhibitors
Authors: Sharma Monika , Jha Prakash , Verma Priyanka , Chopra Madhu 
Published: January 2019

AbstractHuman histone deacetylase isoform 6 (HDAC6) has been shown to have an immense role in cell motility and aggresome formation and is being an attractive selective target for the treatment of multiple tumour types and neurodegenerative conditions. The discovery of selective HDAC6 inhibitors with new chemical functionalities is therefore of utmost interest to researchers. In order to examine the structural requirements for HDAC6‐specific inhibitors and to derive predictive model which can be used for designing new selective HDAC6 inhibitors, a three‐dimensional quantitative structure–activity relationship study was carried out on a diverse set of ligands using common feature‐based pharmacophore alignment followed by employing comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) techniques. The models displayed high correlation of 0.978 and 0.991 for best CoMFA and CoMSIA models, respectively, and a good statistical significance. The model could be used for predicting activities of the test set compounds as well as for deriving useful information regarding steric, electrostatic, hydrophobic properties of the molecules used in this study. Further, the training and test set molecules were docked into the HDAC6 binding site and molecular dynamics was carried out to suggest structural requirements for design of new inhibitors.
Design, synthesis, and biological evaluation of 4‐aminopyrimidine or 4,6‐diaminopyrimidine derivatives as beta amyloid cleaving enzyme‐1 inhibitors
Authors: Xu Xiufeng , Lü Peng , Wang Junjie , Xu Fengrong , Liang Lei , Wang Chao , Niu Yan , Xu Ping 
Published: January 2019

AbstractA series of novel aminopyrimidine and diaminopyrimidine derivatives were designed and optimized to improve their potency and permeability relative to lead compound 1 (IC50 = 37.4 μM), which was discovered in a previous virtual screening. The potency of the optimized compound, 13g (IC50 = 1.4 μM), was 26‐fold greater than that of 1 based on a fluorescence resonance energy transfer assay, and a parallel artificial membrane permeability assay suggested that it could pass through the blood‐brain barrier. Additionally, several compounds containing selenium showed good potencies and deserve further investigation as anti‐Alzheimer's agents.
Distinguishing pustular psoriasis and acute generalized exanthematous pustulosis on the basis of plasmacytoid dendritic cells and MxA protein
Authors: Vyas Nikki S. , Charifa Ahmad , Desman Garrett T. , McNiff Jennifer M. 
Published: January 2019

BackgroundDistinguishing acute generalized exanthematous pustulosis (AGEP) and pustular psoriasis (PS) can be challenging. Staining for plasmacytoid dendritic cells, or PDCs (producer of IFN‐α/β), and MxA (an IFN‐α/β inducible protein) may help discriminate these entities.MethodsForty‐three cases of AGEP and PS were compiled from two academic institutions. All cases were examined for CD123+ PDCs, eosinophils, acanthosis, papillomatosis, suprapapillary plate thinning, tortuous dilated capillaries, single necrotic keratinocytes, papillary dermal edema, vasculitis, eosinophil exocytosis, intraepidermal pustules, and subcorneal pustules. A subset of cases (n = 26) was stained for MxA.ResultsPerivascular and intraepidermal PDCs, dilated tortuous vessels, and MxA expression in the dermal inflammatory infiltrate were significantly (P < 0.05) in favor of a diagnosis of PS. The absence of PDCs and presence of eosinophils favored a diagnosis of AGEP (P < 0.05).ConclusionsWe found compelling evidence for the use of CD123 to highlight PDCs in these cases. The presence of PDCs and expression of MxA in dermal inflammatory infiltrate, as well as absence of eosinophils and presence of tortuous dilated capillaries favored a diagnosis of PS. Expression of MxA in the dermal infiltrate corresponds with a Th1 pathway in PS and may indicate a Th1 component in the early initial phase of AGEP.
Positive Parenting and Parental Conflict: Contributions to Resilient Coparenting During Divorce
Authors: Becher Emily H. , Kim Hyunjun , Cronin Sarah E. , Deenanath Veronica , McGuire Jenifer K. , McCann Ellie M. , Powell Sharon 
Published: January 2019

ObjectiveTo examine the influence of positive parenting and parental conflict on the coparenting alliance.BackgroundResearch indicates that child and family outcomes after divorce are affected by the quality of the coparenting relationship between parents, with many divorce education programs focusing on coparenting as a core programmatic component. Less is known about how positive parenting and parental conflict affect the coparenting alliance.MethodThis study collected online survey data from a convenience sample of divorcing parents (N = 430). Participants completed measures of parenting, parental conflict, and coparenting alliance. Regression and simple slope analyses were performed with parental conflict and positive parenting as predictors of coparenting alliance.ResultsPositive parenting and parenting conflict both predicted the coparenting alliance. Low levels of conflict predicted high levels of coparenting when positive parenting was high and moderate; however, conflict did not predict alliance when positive parenting was low.ConclusionParents who engaged in moderate to high positive parenting had the anticipated negative relationship between conflict and coparenting alliance, but this did not hold true for parents who engaged in below average positive parenting, suggesting that both parenting and conflict play a role in a resilient coparenting alliance.ImplicationsDivorcing parents' parenting skills may be important to consider when deciding on prevention and intervention efforts aimed at supporting their coparenting alliance. Therefore, divorce education programs may benefit from incorporating content related to positive parenting and parents with weaker parenting practices may need different types of intervention.
Headaches Attributed to Ischemic Stroke and Transient Ischemic Attack
Authors: Oliveira Felipe Araujo Andrade , Sampaio Rocha‐Filho Pedro Augusto 
Published: January 2019

IntroductionAlthough headaches attributed to ischemic strokes and transient ischemic attack occur frequently, they are often overlooked and underdiagnosed as manifestations of cerebrovascular disease.MethodThis is a narrative review.ResultsThe prevalence of headache attributed to ischemic stroke varies between 7.4% and 34% of cases and of headache attributed to transient ischemic attack, from 26% to 36%. Headache attributed to ischemic stroke is more frequent in younger patients, in migraineurs, in those who have suffered a larger stroke, a posterior circulation infarction, or a cortical infarction, and is less frequent in lacunar infarctions. The most common pattern of headache attributed to ischemic stroke is a mild to moderate bilateral pain, not associated with nausea, vomiting, photophobia, or phonophobia. This headache usually has a concomitant onset with focal neurologic deficit and improves over time. The few studies that have assessed the value of headache for a prognosis of ischemic strokes have demonstrated conflicting results. There are no clinical trials on pain management or prophylactic treatment of persistent headache attributed to ischemic stroke.ConclusionHeadache attributed to ischemic stroke is frequent and usually has a tension‐type headache pattern. Its frequency varies according to the stroke’s etiology. Further studies are required on pain management, prophylactic treatment, and characteristics of this headache.
FISCAL STIMULUS WITH LEARNING‐BY‐DOING
Authors: D'Alessandro Antonello , Fella Giulio , Melosi Leonardo 
Published: January 2019

AbstractUsing a Bayesian structural vector autoregression analysis, we document that an increase in government purchases raises private consumption, the real wage, and total factor productivity (TFP) while reducing inflation. These three facts are hard to reconcile with both neoclassical and New Keynesian models. We extend a standard New Keynesian model to allow for skill accumulation through past work experience. An increase in government spending increases hours and induces skill accumulation and higher measured TFP and real wages in subsequent periods. Future marginal costs fall lowering expected inflation and, through the monetary policy rule, the real interest rate. Consumption increases as a result.
Cross‐National Solidarity and Political Sustainability in the EU after the Crisis
Authors: Ferrera Maurizio , Burelli Carlo 
Published: January 2019

AbstractThe recent economic shocks have severely tested the EU's political sustainability. The deep‐rooted and unending succession of existential crises demonstrates the sharp misalignment between the high degree of integration reached by the EU, its authority structure, and the absence of solidarity to sustain this structure. The contribution unfolds as follows: first, we claim that the Union has become a complex adaptive system and that attempts to restore thestatus quo anteare unrealistic. Section II shows that its authority structure is ill‐suited to steering the complex system because it lacks adequate instruments for addressing common risks and democratic externalities. Section III argues that contemporary EU leaders are failing to promote the principles of solidarity which, according to its founding father are required to disarm centrifugal tendencies. Section IV presents empirical evidence which signals the existence of considerable popular support for these pan‐European forms of solidarity.
Perceived HIV‐related physical fatigue, sociodemographic characteristics and physical activity: A cross‐sectional study
Authors: Bergamaschi Alessandro , d'Arripe‐Longueville Fabienne , Gray Laura L. , Colson Serge S. , Goujard Cecile , Ferez Sylvain , Rouanet Isabelle , Durant Jacques , Rosenthal Eric , Pradier Christian , Duracinsky Martin , Schuft Laura 
Published: January 2019

AbstractAims and objectivesTo get a deeper understanding of correlates of perceived HIV‐related fatigue by exploring its associations with sociodemographic characteristics and physical activity level of HIV‐infected people.BackgroundPrevious studies on HIV‐related fatigue have mainly focused on physiological and psychological characteristics, but few have considered its associations with sociodemographic variables. In addition, while physical activity has been found to reduce acute fatigue among HIV‐infected people, its links with chronic HIV‐related fatigue remain to be explored.DesignThe study employed an observational and cross‐sectional survey design. The manuscript was organised according to STROBE guidelines.MethodA total of 560 people living with HIV in France completed a measure of perceived physical fatigue using the Fatigue Intensity Scale. The predictors targeted sociodemographic characteristics and two measures of individuals' reported level of physical activity. Data were analysed by a stepwise multiple regression model.ResultsThe results showed that lower age, higher physical activity level and socio‐economic status were significantly associated with reduced perceived physical fatigue, explaining 25% of the variance.ConclusionsThe results highlighted the importance of considering sociodemographic and lifestyle characteristics to better characterise HIV‐related fatigue, in particular in an era where HIV as a chronic illness challenges questions of quality of life throughout increasingly longer lifespans.Relevance to clinical practiceThe results of this study have implications for HIV care professionals in terms of improving strategies for managing chronic fatigue or promoting physical activity according to more specific profiles of HIV‐infected people.
Patients’ experience with heart failure treatment and self‐care—A qualitative study exploring the burden of treatment
Authors: Nordfonn Oda Karin , Morken Ingvild Margreta , Bru Lars Edvin , Husebø Anne Marie Lunde 
Published: January 2019

AbstractAims and objectivesTo explore chronic heart failure patients’ perceptions of the burden related to treatment and self‐care.BackgroundLiving with chronic heart failure entails following a demanding treatment regimen, with daily self‐care, which could make patients vulnerable to experiencing treatment burden. Burden of treatment is defined as the “work” the healthcare system passes on to the patients with respect to self‐care at home, and the impact this has on well‐being and quality of life. However, the burden of treatment is an emergent framework, and further research exploring burden among heart failure patients is required.DesignQualitative study employing semi‐structured interviews and content analysis. The study complied with the Consolidated Criteria for Reporting Qualitative Research (COREQ).MethodsA sample of 17 heart failure patients recruited from an outpatient clinic in Norway. Interview transcripts were coded in Nvivo 11 and analysed using Malterud's systematic text condensation.ResultsTwo main themes “emotional challenge” and “troublesome self‐care” emerged from the analysis. The first theme contained the following subthemes: “a new life situation,” “monitoring body signals,” “difficult transitions” and “feelings of guilt.” The second theme consisted of the subthemes “poor care coordination,” “lack of information and education” and “troublesome medication.”ConclusionHeart failure treatment constitutes challenges related both to self‐care and to emotional burden. The latter not previously clearly articulated in the concept of burden of treatment. Many patients are struggling emotionally, and this affects their self‐care ability in addition to affecting their well‐being and quality of life.Relevance to Clinical PracticeNurses are in a strategic position to play a pivotal role in identifying and responding to the emotional burden of treatment in heart failure patients, furthermore to guide and support in discharge planning and in outpatient setting to reduce the patients’ emotional distress and fear of failing.
Self‐Control, Effort Procrastination, and Competitive Equilibrium in Insurance Markets
Authors: Ai Jing , Zhao Lin , Zhu Wei 
Published: January 2019

AbstractThis article studies consumers’ self‐control problems in precautionary activities, their contract choices, and the welfare implications in a competitive insurance market. Present bias and consumer naivete both induce consumers to procrastinate or eventually give up precautionary efforts. In consequence, self‐control problems disrupt the monotonicity of consumers’ indifference curve on contract choices, leading to a pooling equilibrium or an absence of risk–coverage correlation, in addition to the classic result of adverse selection. Compulsory insurance raises all consumers’ welfare only in adverse selection, but not in other equilibrium patterns.
Origin and evolution of sex‐determination systems in the brown algae
Authors: Coelho Susana M. , Mignerot Laure , Cock J. Mark 
Published: January 2019

SummarySexual reproduction is a nearly universal feature of eukaryotic organisms. Meiosis appears to have had a single ancient origin, but the mechanisms underlying male or female sex determination are diverse and have emerged repeatedly and independently in the different eukaryotic groups. The brown algae are a group of multicellular photosynthetic eukaryotes that have a distinct evolutionary history compared with animals and plants, as they have been evolving independently for over 1 billion yr. Here, we review recent work using the brown alga Ectocarpus as a model organism to study haploid sex chromosomes, and highlight how the diversity of reproductive and life cycle features of the brown algae offer unique opportunities to characterize the evolutionary forces and the mechanisms underlying the evolution of sex determination.
Influence of Porphyromonas gingivalis in gut microbiota of streptozotocin‐induced diabetic mice
Authors: Ohtsu Anri , Takeuchi Yasuo , Katagiri Sayaka , Suda Wataru , Maekawa Shogo , Shiba Takahiko , Komazaki Rina , Udagawa Sayuri , Sasaki Naoki , Hattori Masahira , Izumi Yuichi 
Published: January 2019

AbstractObjectivesIncreasing evidence suggests that periodontitis can exacerbate diabetes, and gut bacterial dysbiosis appears to be linked with the diabetic condition. The present study examined the effects of oral administration of the periodontopathic bacterium, Porphyromonas gingivalis, on the gut microbiota and systemic conditions in streptozotocin‐induced diabetic mice.Materials and MethodsDiabetes was induced by streptozotocin injection in C57BL/6J male mice (STZ). STZ and wild‐type (WT) mice were orally administered P. gingivalis (STZPg, WTPg) or saline (STZco, WTco). Feces were collected, and the gut microbiome was examined by 16S rRNA gene sequencing. The expression of genes related to inflammation, epithelial tight junctions, and glucose/fatty acid metabolism in the ileum or liver were examined by quantitative PCR.ResultsThe relative abundance of several genera, including Brevibacterium, Corynebacterium, and Facklamia, was significantly increased in STZco mice compared to WTco mice. The relative abundances of Staphylococcus and Turicibacter in the gut microbiome were altered by oral administration of P. gingivalis in STZ mice. STZPg mice showed higher concentrations of fasting blood glucose and inflammatory genes levels in the ileum, compared to STZco mice.ConclusionsOral administration of P. gingivalis altered the gut microbiota and aggravated glycemic control in streptozotocin‐induced diabetic mice.