bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valuation of the Quality Attributes of Online Banking Services by Small and Medium Enterprises Engaged in International Trade
Authors: Shahnoori Parvaneh , Jenkins Glenn P. 
Published: March 2019

AbstractThis study investigates the important attributes of online banking system for Small and Medium Enterprises (SMEs) and their willingness to pay for each attribute. Zero travel and waiting time, high security, and 24/7 accessibility are the key attributes for this service. The results show that SMEs engaged in international trade value online banking services significantly more than the others. Domestically focused firms value high‐quality service at about $163 a month, while import‐focused businesses value such a service at approximately US$646 per month. Export‐intensive SMEs value high‐quality online services 14% further, for an average of $736 per month.
Cardiovascular adaptations associated with exercise in patients on hemodialysis
Authors: Graham‐Brown Matthew P.M. , Jardine Meg J. , Burton James O. 
Published: March 2019

AbstractPatients on hemodialysis are physically inactive. Less than 50% of hemodialysis patients undertake exercise once a week and such patients have increased mortality compared to patients who undertake regular exercise. The reasons for physical inactivity and reduced functional capacity are complex and inter‐related, with skeletal muscle catabolism, chronic inflammation, anemia, malnutrition, uremia, the burden of co‐morbid diseases, and “enforced” sedentary time during hemodialysis all contributing. Many of these factors drive cardiovascular disease (CVD) processes in this cohort of patients and in the general population, exercise interventions have been shown to modify many of these risk factors. Whilst there is increasing evidence about the beneficial effects of exercise interventions on quality of life, functional capacity, aerobic fitness, and muscular strength, there are few compelling data on the effects of such programs on cardiovascular outcome measures. The reasons for this are manifold and include: limitations in study size; inconsistencies in study design; the heterogeneous nature of exercise interventions; assessment of nonstandardized outcome measures and; a lack of understanding of what changes in certain traditional measures of CVD (such as blood pressure or lipid profile) mean for patients on hemodialysis. This review summarizes the current evidence base for the effects of exercise on traditional and nontraditional cardiovascular risk factors and the effects of exercise interventions on cardiovascular structure and function, including a review of study limitations and future research priorities.
Psychometric properties of the Internet Gaming Disorder Test (IGDT‐10) and problematic gaming behavior among Finnish vocational school students
Authors: Männikkö Niko , Ruotsalainen Heidi , Tolvanen Asko , Kääriäinen Maria 
Published: March 2019

This study was conducted to investigate the psychometric properties of the Finnish version of the Internet Gaming Disorder Test (IGDT‐10), identify the proportion displaying problematic gaming behavior (PGB) among Finnish vocational school students, and characterize the relationships between sociodemographic factors and gaming characteristics predicting PGB in this population. This cross‐sectional study involving 773 students (mean age 17.5 years). Socio‐demographic and gaming behavior characteristics were established using a web‐based survey. A confirmatory factor analysis (CFA) showed that the IGDT‐10 test has appropriate psychometric properties. The proportion of students exhibiting PGB based on the DSM‐5 cut‐off threshold was 1.3%. Regression analysis showed that male gender, preference for gaming on a personal computer, gaming time, poor self‐perceived health status, and a preference for the solo and multiplayer online battle arenas (MOBA) game genres related positively to PGB scores. These findings demonstrate the appropriateness of the IGDT‐10 test for the assessment of problematic gaming among adults, and support further research on PGB in Finland.
Elementary teachers’ mathematical beliefs and mathematics anxiety: How do they shape instructional practices?
Authors: Hughes Pamela , Swars Auslander Susan , Stinson David W. , Fortner C. Kevin 
Published: March 2019

AbstractThis quantitative study investigated the relationships among practicing elementary teachers’ (N = 153) beliefs about mathematics and its teaching and learning, mathematics anxiety, and instructional practices in mathematics. When viewed singly, the findings reveal the teachers with higher levels of mathematics anxiety tend to use less standards‐based instruction and those with beliefs oriented toward a problem‐solving view of mathematics reported more standards‐based teaching. A combined analysis shows that after controlling for mathematical beliefs, teaching longevity, and educational degree attainment, there is no relationship between teachers’ mathematics anxiety and instructional practices. These findings suggest a spurious relationship between anxiety and practices, with beliefs having the strongest relationship with practices. Several suggestions for positively influencing the mathematical beliefs and affect in general of elementary teachers while learning mathematics are offered.
Enhanced activity of multiple TRIC‐B channels: an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents
Authors: O'Brien Fiona , Eberhardt David , Witschas Katja , El‐Ajouz Sam , Iida Tsunaki , Nishi Miyuki , Takeshima Hiroshi , Sitsapesan Rebecca , Venturi Elisa 
Published: March 2019

Key points
There are two subtypes of trimeric intracellular cation (TRIC) channels but their distinct single‐channel properties and physiological regulation have not been characterized. We examined the differences in function between native skeletal muscle sarcoplasmic reticulum (SR) K+‐channels from wild‐type (WT) mice (where TRIC‐A is the principal subtype) and from Tric‐a knockout (KO) mice that only express TRIC‐B.
We find that lone SR K+‐channels from Tric‐a KO mice have a lower open probability and gate more frequently in subconducting states than channels from WT mice but, unlike channels from WT mice, multiple channels gate with high open probability with a more than six‐fold increase in activity when four channels are present in the bilayer.
No evidence was found for a direct gating interaction between ryanodine receptor and SR K+‐channels in Tric‐a KO SR, suggesting that TRIC‐B–TRIC‐B interactions are highly specific and may be important for meeting counterion requirements during excitation–contraction coupling in tissues where TRIC‐A is sparse or absent.
AbstractThe trimeric intracellular cation channels, TRIC‐A and TRIC‐B, represent two subtypes of sarcoplasmic reticulum (SR) K+‐channel but their individual functional roles are unknown. We therefore compared the biophysical properties of SR K+‐channels derived from the skeletal muscle of wild‐type (WT) or Tric‐a knockout (KO) mice. Because TRIC‐A is the major TRIC‐subtype in skeletal muscle, WT SR will predominantly contain TRIC‐A channels, whereas Tric‐a KO SR will only contain TRIC‐B channels. When lone SR K+‐channels were incorporated into bilayers, the open probability (Po) of channels from Tric‐a KO mice was markedly lower than that of channels from WT mice; gating was characterized by shorter opening bursts and more frequent brief subconductance openings. However, unlike channels from WT mice, the Po of SR K+‐channels from Tric‐a KO mice increased as increasing channel numbers were present in the bilayer, driving the channels into long sojourns in the fully open state. When co‐incorporated into bilayers, ryanodine receptor channels did not directly affect the gating of SR K+‐channels, nor did the presence or absence of SR K+‐channels influence ryanodine receptor activity. We suggest that because of high expression levels in striated muscle, TRIC‐A produces most of the counterion flux required during excitation‐contraction coupling. TRIC‐B, in contrast, is sparsely expressed in most cells and, although lone TRIC‐B channels exhibit low Po, the high Po levels reached by multiple TRIC‐B channels may provide a compensatory mechanism to rapidly restore K+ gradients and charge differences across the SR of tissues containing few TRIC‐A channels.
Neurons of the inferior olive respond to broad classes of sensory input while subject to homeostatic control
Authors: Ju Chiheng , Bosman Laurens W.J. , Hoogland Tycho M. , Velauthapillai Arthiha , Murugesan Pavithra , Warnaar Pascal , van Genderen Romano M. , Negrello Mario , De Zeeuw Chris I. 
Published: March 2019

Key points
Purkinje cells in the cerebellum integrate input from sensory organs with that from premotor centres.
Purkinje cells use a variety of sensory inputs relaying information from the environment to modify motor control.
Here we investigated to what extent the climbing fibre inputs to Purkinje cells signal mono‐ or multi‐sensory information, and to what extent this signalling is subject to recent history of activity.
We show that individual climbing fibres convey multiple types of sensory information, together providing a rich mosaic projection pattern of sensory signals across the cerebellar cortex.
Moreover, firing probability of climbing fibres following sensory stimulation depends strongly on the recent history of activity, showing a tendency to homeostatic dampening.
AbstractCerebellar Purkinje cells integrate sensory information with motor efference copies to adapt movements to behavioural and environmental requirements. They produce complex spikes that are triggered by the activity of climbing fibres originating in neurons of the inferior olive. These complex spikes can shape the onset, amplitude and direction of movements and the adaptation of such movements to sensory feedback. Clusters of nearby inferior olive neurons project to parasagittally aligned stripes of Purkinje cells, referred to as ‘microzones’. It is currently unclear to what extent individual Purkinje cells within a single microzone integrate climbing fibre inputs from multiple sources of different sensory origins, and to what extent sensory‐evoked climbing fibre responses depend on the strength and recent history of activation. Here we imaged complex spike responses in cerebellar lobule crus 1 to various types of sensory stimulation in awake mice. We find that different sensory modalities and receptive fields have a mild, but consistent, tendency to converge on individual Purkinje cells, with climbing fibres showing some degree of input‐specificity. Purkinje cells encoding the same stimulus show increased events with coherent complex spike firing and tend to lie close together. Moreover, whereas complex spike firing is only mildly affected by variations in stimulus strength, it depends strongly on the recent history of climbing fibre activity. Our data point towards a mechanism in the olivo‐cerebellar system that regulates complex spike firing during mono‐ or multi‐sensory stimulation around a relatively low set‐point, highlighting an integrative coding scheme of complex spike firing under homeostatic control.
Causes and consequences of unintended pregnancies in the Gaza Strip: a qualitative study
Authors: Böttcher Bettina , Abu-El-Noor Mysoon Abdelaziz , Abu-El-Noor Nasser Ibrahim 
Published: March 2019

BackgroundLittle is known about unintended pregnancies in the Gaza Strip. This study explored causes and consequences of unintended pregnancies among women in the Gaza Strip.MethodsThis was a qualitative study, and included 21 women who had experienced unintended pregnancies previously. Data collection took place in three focus groups of 5–12 participants, which were facilitated by one female researcher. Structured questions on reasons for, causes and impact of unintended pregnancies were answered by all participants. Sessions were audiotaped and responses were transcribed and read by all the researchers to extract themes.ResultsThe mean age of participants was 34.2±6.0 years, parity was 2.7±0.6 and 16 participants (76.2%) had benefitted from secondary level education or above.Five main themes were identified: (1) economic hardship was the main reason for pregnancies to be unwanted; (2) high pressure was exerted on women for male babies, exposing women to gender-based violence; (3) advanced maternal age was perceived as a social stigma; (4) complete lack of support for women facing unintended pregnancy led to self-management of terminations including attempts of unsafe methods; and (5) changes of methods and incorrect use leading to contraceptive failure was the most frequent cause.ConclusionsUnintended pregnancies in the Gaza Strip are a common cause of distress for women. The most effective way of preventing unintended pregnancies remains access to reliable contraception. However, a service designated to support women facing unintended pregnancies is needed in the Gaza Strip. Local policymakers have to address this when planning healthcare services.
Prevalence of heart failure and other risk factors among first-degree relatives of women with peripartum cardiomyopathy
Authors: Christiansen Mia Nielsen , Køber Lars , Torp-Pedersen Christian , Smith J Gustav , Gustafsson Finn , Vejlstrup Niels G , Damm Peter , Johansen Marianne , Andersson Charlotte , Ersbøll Anne S 
Published: March 2019

ObjectivesPeripartum cardiomyopathy (PPCM) is a rare disease carrying a risk of death and chronic heart failure.It is unknown if women with PPCM have a family history of heart failure. We investigated the prevalence of heart failure and hypertension in first-degree relatives to women with PPCM.MethodsA cohort of 61 women with PPCM was identified through the nationwide Danish registers from 2005 to 2014, and each individual diagnosis of PPCM was validated through review of patient records. We excluded 13 women due to lack of data on relatives. In a case–control design, the 48 remaining women were matched (on age, year of childbirth, parity and number of siblings) to 477 birth-giving Danish women without heart failure. We obtained information on first-degree relatives (parents and siblings) through the National Danish Registers.ResultsThe cohort of 48 women with PPCM had a mean age of 31 years (SD 6). The prevalence of heart failure in any first-degree relative was higher in women with PPCM, compared with controls (23% vs 10%, p=0.011). A first-degree relative with any cardiovascular diagnosis was not more frequent in women with PPCM versus controls (77% vs 70%, p=0.280), but for siblings only, any cardiovascular diagnosis was more frequent in siblings to women with PPCM (29% vs 16%, p=0.026).ConclusionHaving a first-degree relative with heart failure was significantly more frequent in a cohort of validated PPCM cases than in controls, supporting the notion of shared aetiology between PPCM and other forms of heart failure.
Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling
Authors: Lakshmanachetty Senthilnath , Balaiya Velmurugan , High Whitney A. , Koster Maranke I. 
Published: March 2019

Abstract

TP63 is frequently amplified or overexpressed in primary head and neck squamous cell carcinomas (HNSCC). Nevertheless, the role of TP63 in the initiation and progression of HNSCCs is not known. Using archival HNSCC tissue sections, we found that TP63 expression is often downregulated in late-stage human HNSCCs. To establish a causal link between TP63 loss and HNSCC tumorigenesis, we developed a genetically engineered mouse model in which Trp63 (the mouse homolog of human TP63) was ablated from head and neck epithelia. Upon exposure of the mice to a chemical carcinogen, we found that Trp63 ablation accelerated HNSCC initiation and progression. To determine whether these findings are relevant for human HNSCCs, we generated TP63 knockdown HNSCC cell lines. These cells were implanted into the tongue of athymic nude mice to generate orthotopic xenografts. We found that loss of TP63 promoted HNSCC progression and metastasis. Furthermore, we determined that tumor metastasis is dependent on MAPK activation in TP63 knockdown HNSCCs. The significance of these findings is underscored by our finding that pharmacologic inhibition of MAPK activity by trametinib drastically impaired HNSCC metastasis mediated by TP63 loss. In conclusion, our data provide novel mechanistic insights into the role of TP63 loss in HNSCC initiation and progression, and provide a rationale for the development of new therapeutic approaches specifically targeting TP63-dependent tumor pathways.

Implications:
Our findings uncover a novel functional role for TP63 loss in HNSCC metastasis and identify MAPK signaling as a potential therapeutic target for treating HNSCCs with low TP63 expression.
Аналіз хірургічного лікування хворих на первинну та післяопераційну вентральні грижі в період із 2001 до 2017 року
Authors: Piatnochka V. P. 
Published: March 2019

Мета роботи: проаналізувати та оцінити результати хірургічного лікування хворих на первинні та післяопераційні вентральні грижі для підвищення ефективності операційного лікування даної групи пацієнтів.
Матеріали і методи. У період із 2001 до 2017 р. проведено комплексне клініко-інструментальне та лабораторне обстеження 1419 хворих на первинну вентральну грижу (ПВГ) та післяопераційну вентральну грижу (ПОВГ). Пацієнтів розподілено на групи відповідно до періодів хірургічного лікування хворих, сформовано два періоди: з 2001 до 2009 р. та з 2010 до 2017 р. Протягом першого періоду обстежено та прооперовано 597 (42,07 %) хворих. Дані пацієнти склали групу порівняння. Основна група – пацієнти, проліковані в період з 2010 до 2017 р. – 822 (57,93 %) особи.
Результати дослідження та їх обговорення. Протягом двох періодів дослідження спостерігали переважання числа післяопераційних вентральних гриж порівняно з первинними вентральними грижами. При оцінці розмірів та поширення грижового дефекту в обох групах спостерігали переважання за локалізацією серединних із поширенням на інші анатомічні ділянки передньої черевної стінки великих за розмірами гриж, переважно серед осіб з післяопераційними вентральними грижами. Прослідковується тенденція зміни техніки операційних методів лікування вентральних гриж – від натяжних (власне тканинні, «on lay») до ненатяжних («sub lay», «in lay», «CST»), а також від використання «важких» до «легких» поліпропіленових сіток. Врахування особливостей модифікації проведених операційних втручань та вибору типу сітчастого імпланту знайшли своє відображення в значному зменшенні числа ранніх як місцевих, так і загальних, та пізніх післяопераційних ускладнень, що, у свою чергу, покращило ефективність хірургічного лікування хворих із первинними та післяопераційними вентральними грижами.
Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell
Authors: Sun Chiao-Wang , Yang Jiangning , Kleschyov Andrei L. , Zhuge Zhengbing , Carlström Mattias , Pernow John , Wajih Nadeem , Isbell T. Scott , Oh Joo-Yeun , Cabrales Pedro , Tsai Amy G. , Townes Tim , Kim-Shapiro Daniel B. , Patel Rakesh P. , Lundberg Jon O. 
Published: March 2019

Background:
Nitrosation of a conserved cysteine residue at position 93 in the hemoglobin β chain (β93C) to form S-nitroso (SNO) hemoglobin (Hb) is claimed to be essential for export of nitric oxide (NO) bioactivity by the red blood cell (RBC) to mediate hypoxic vasodilation and cardioprotection.

Methods:
To test this hypothesis, we used RBCs from mice in which the β93 cysteine had been replaced with alanine (β93A) in a number of ex vivo and in vivo models suitable for studying export of NO bioactivity.

Results:
In an ex vivo model of cardiac ischemia/reperfusion injury, perfusion of a mouse heart with control RBCs (β93C) pretreated with an arginase inhibitor to facilitate export of RBC NO bioactivity improved cardiac recovery after ischemia/reperfusion injury, and the response was similar with β93A RBCs. Next, when human platelets were coincubated with RBCs and then deoxygenated in the presence of nitrite, export of NO bioactivity was detected as inhibition of ADP-induced platelet activation. This effect was the same in β93C and β93A RBCs. Moreover, vascular reactivity was tested in rodent aortas in the presence of RBCs pretreated with S-nitrosocysteine or with hemolysates or purified Hb treated with authentic NO to form nitrosyl(FeII)-Hb, the proposed precursor of SNO-Hb. SNO-RBCs or NO-treated Hb induced vasorelaxation, with no differences between β93C and β93A RBCs. Finally, hypoxic microvascular vasodilation was studied in vivo with a murine dorsal skin-fold window model. Exposure to acute systemic hypoxia caused vasodilatation, and the response was similar in β93C and β93A mice.

Conclusions:
RBCs clearly have the fascinating ability to export NO bioactivity, but this occurs independently of SNO formation at the β93 cysteine of Hb.
Response of Southern China Winter Rainfall to El Niño Diversity and Its Relevance to Projected Southern China Rainfall Change
Authors: Wang Qiang , Cai Wenju , Zhong Wenxiu , Zeng Lili , Wu Lixin , Wang Dongxiao 
Published: March 2019

AbstractResponding to El Niño diversity, greater winter southern China (SC) rainfall is associated with an anomalous warming in the eastern tropical Pacific, but less rainfall with an anomalous warming in the central tropical Pacific. Compared with other widely used indices, the first two principal components of sea surface temperature anomalies in the tropical Pacific better represent the influences of the different El Niño anomaly patterns on winter SC rainfall. This is because these two indices can distinguish a zonal shift of the west North Pacific anticyclone, which conveys the tropical Pacific influence on SC rainfall. At a positive phase, the first principal component features a pattern similar to that of a canonical El Niño, whereas the second component is characterized by a warming in the central Pacific. Based on these two indices, performance of phase 5 of the Coupled Model Intercomparison Project models in simulating the SC rainfall response to El Niño is evaluated. About half of the models cannot reproduce the response to either principal component. The majority of the remaining models can only simulate the response to one principal component, and only five models produce a reasonable response to both principal components. Importantly, changes to SC rainfall in the future depend on the simulation of the SC rainfall response. Models that simulate the teleconnection of SC rainfall with only the first (second) principal component project an increase (decrease) in SC rainfall. Projection of a rainfall change in models that simulate the teleconnection with both principal components, that is, a moderate increase in SC winter rainfall, is more credible.