bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ozone and heat-related mortality in Europe in 2050 significantly affected by changes in climate, population and greenhouse gas emission
Authors: Orru Hans , Åström Christofer , Andersson Camilla , Tamm Tanel , Ebi Kristie L , Forsberg Bertil 
Published: April 2019

Abstract
Climate change is expected to increase to extreme temperatures and lead to more intense formation of near-surface ozone. Higher temperatures can cause heat stress and ozone is a highly oxidative pollutant; both increase cardiorespiratory mortality. Using greenhouse gas and ozone precursor emission scenarios, global and regional climate and chemistry-transport models, epidemiological data, and population projections, we projected ozone- and heat-related health risks under a changing climate. European near-surface temperature was modelled with the regional climate model (RCA4), forced by the greenhouse gas emission scenario RCP4.5 and the global climate model EC-EARTH, and near-surface ozone was modelled with the Multi-scale Atmospheric Transport and Chemistry (MATCH) model. Two periods were compared: recent climate in 1991–2000 and future climate in 2046–2055, projecting around a 2° increase in global temperatures by that time. Projections of premature mortality considered future climate, future population, and future emissions separately and jointly to understand the relative importance of their contributions. Ozone currently causes 55 000 premature deaths annually in Europe due to long-term exposure, including a proportion of the estimated 26 000 deaths per year due to short-term exposures. When only taking into account the impact of a changing climate, up to an 11% increase in ozone-associated mortality is expected in some countries in Central and Southern Europe in 2050. However, projected decreases in ozone precursor emissions are expected to result in a decrease in ozone-related mortality (−30% as EU average). Due to aging and increasingly susceptible populations, the decrease in 2050 would be smaller, up to −24%. During summer months, ozone risks could combine with increasing temperatures, especially during the hottest periods and in densely populated urban areas. While the heat burden is currently of the same order of magnitude as ozone, due to increasing temperatures and decreasing ozone precursor emissions, heat-related mortality could be twice as large as ozone-related mortality in 2050.
CD161 Is Expressed in a Subset of T-Cell Prolymphocytic Leukemia Cases and Is Useful for Disease Follow-up
Authors: Gilles Scott R , Yohe Sophia L , Linden Michael A , Dolan Michelle , Hirsch Betsy , Grzywacz Bartosz 
Published: April 2019

AbstractObjectivesCD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment.MethodsRetrospective review of T-PLL cases with complete flow cytometry data including CD161.ResultsWe identified 10 cases of T-PLL with flow cytometric evaluation of CD161 available. Six of these cases were positive for CD161 expression. All CD161-positive cases were positive for CD8 with variable CD4 expression, whereas all CD161-negative cases were negative for CD8. In a case with two neoplastic subsets positive and negative for CD8, only the former expressed CD161.ConclusionsThese novel results suggest that CD161 is often aberrantly expressed in a defined subset of T-PLL positive for CD8. We are showing the utility of this immunophenotype in diagnosis and follow-up.
Ten-Year Safety Data for Eurosilicone’s Round and Anatomical Silicone Gel Breast Implants
Authors: Duteille Franck , Perrot Pierre , Bacheley Marie-Hélène , Bell Erin , Stewart Sharon 
Published: April 2019

Abstract

Background
Although silicone breast implants have been available for over 60 years, their safety and efficacy continue to be assessed via long-term clinical and vigilance studies. Complications often associated with breast implant surgery include but are not limited to capsular contracture and rupture.

Objective
The authors investigate and evaluate the safety and performance of Eurosilicone’s (Eurosilicone S.A.S, Apt Cedex, France) Cristalline Paragel breast implants at least 10 years postimplantation.

Methods
Nine hundred and ninety-five of Eurosilicone’s textured mammary implants were implanted in 526 women undergoing primary (423 patients) and revision surgery (103 patients) at 17 centers throughout France. Complications were recorded at 3 months and annually thereafter for 10 years. Descriptive statistics were used and the Kaplan-Meier method was utilized to analyze key complications.

Results
Seventy-four women (98 implants) experienced capsular contracture across all cohorts. The Kaplan-Meier 10-year cumulative risk of capsular contracture (Baker Grade III/IV) per implant was 11.5% in the primary augmentation cohort and 25.2% in the primary reconstruction cohort. Sixteen implant ruptures were observed by surgeon examination giving a Kaplan-Meier risk of 3.8% per patient and 3.5% per implant. Surgical re-intervention (explantation/exchange) was reported 80 times resulting in a Kaplan-Meier cumulative risk of 13.3% and 31.6% for primary augmentation and primary reconstruction, respectively, per patient. Local complication rates including infection and seroma were low with risk rates of 0.6% and 0.2% by subject.

Conclusions
This multicenter clinical study demonstrates the long-term safety and efficacy profile through 10 years for Eurosilicone round and anatomical silicone gel breast implants.

Level of Evidence: 3
The safety and efficacy of mycophenolate mofetil in children and adolescents with steroid-dependent nephrotic syndrome: a single-centre study
Authors: Karunamoorthy Saravanakumar , Thanigachalam Dineshkumar , Jeyachandran Dhanapriya , Ramanathan Sakthirajan , Natarajan Gopalakrishnan , Thoppalan Balasubramaniam 
Published: April 2019

Abstract

Background
Steroid-dependent nephrotic syndrome (SDNS) patients experience frequent relapse or adverse effects on long-term treatment with steroids or cyclophosphamide. This study assessed the efficacy and side effect profile of mycophenolate mofetil (MMF) therapy in children with nephrotic syndrome in our population.

Methods
A retrospective study was performed on children with SDNS who were on MMF therapy for a minimum period of 1 year, and were on regular follow-up in the Department of Nephrology at the Institute of Child Health and hospital for children attached to Madras Medical College.

Results
The study included 87 patients, with a male:female ratio of 2:1. The median age at diagnosis of nephrotic syndrome was 3 years [95% confidence interval (CI): 1–8 years], which was found to be a statistically significant risk factor for MMF failure. The median duration of follow-up after initiation of MMF therapy was 3 years and 3 months (95% CI: 1 year and 3 months to 6 years and 6 months). At initial evaluation, 31 (36%) patients presented with SDNS while the remaining had frequently relapsing nephrotic syndrome progressing to SDNS. Intravenous cyclophosphamide was used as first-line therapy in 82 patients, of whom 24 patients had persistent proteinuria while the remaining 58 had attained remission for a median duration of 6 months. The median duration of treatment with MMF was 2 years and 6 months (95% CI: 1 year and 3 months to 4 years and 6 months). MMF was used at a mean dose of 28.5 mg/kg. Seventy-two (83%) patients were MMF-sensitive, and these patients had a reduction in mean prednisolone dose from 1.28 to 0.35 mg/kg (P &lt; 0.05). Among the MMF-sensitive patients, 31 had stopped MMF after a minimum period of 2 years, following which they had a median remission period of 5 months (95% CI: 1–8 months). MMF failure occurred in 15 (17%) patients. Adverse events were documented in 19 (22%) patients.

Conclusions
Continuous MMF therapy achieved remission in 83% of patients. MMF was well tolerated in the study population and discontinuation of MMF resulted in 100% relapse.
A novel human stem cell model for Coffin–Siris syndrome-like syndrome reveals the importance of SOX11 dosage for neuronal differentiation and survival
Authors: Turan Soeren , Boerstler Tom , Kavyanifar Atria , Loskarn Sandra , Reis André , Winner Beate , Lie Dieter Chichung 
Published: April 2019

AbstractThe SOXC transcription factors Sox4, Sox11 and Sox12, are critical neurodevelopmental regulators that are thought to function in a highly redundant fashion. Surprisingly, heterozygous missense mutations or deletions of SOX11 were recently detected in patients with Coffin–Siris syndrome-like syndrome (CSSLS), a neurodevelopmental disorder associated with intellectual disability, demonstrating that in humans SOX11 haploinsufficiency cannot be compensated and raising the question of the function of SOX11 in human neurodevelopment. Here, we describe the generation of SOX11+/− heterozygous human embryonic stem cell (hESC) lines by CRISPR/Cas9 genome engineering. SOX11 haploinsufficiency impaired the generation of neurons and resulted in a proliferation/differentiation imbalance of neural precursor cells and enhanced neuronal cell death. Using the SOX11+/− hESC model we provide for the first time experimental evidence that SOX11 haploinsufficiency is sufficient to impair key processes of human neurodevelopment, giving a first insight into the pathophysiology of CSSLS and SOX11 function in human neurodevelopment.
The q-Hahn PushTASEP
Authors: Corwin Ivan , Matveev Konstantin , Petrov Leonid 
Published: April 2019

Abstract
We introduce the $q$-Hahn PushTASEP—an integrable stochastic interacting particle system that is a three-parameter generalization of the PushTASEP, a well-known close relative of the TASEP (totally asymmetric simple exclusion process). The transition probabilities in the $q$-Hahn PushTASEP are expressed through the $_4\phi _3$ basic hypergeometric function. Under suitable limits, the $q$-Hahn PushTASEP degenerates to all known integrable (1+1)-dimensional stochastic systems with a pushing mechanism. One can thus view our new system as a pushing counterpart of the $q$-Hahn TASEP introduced by Povolotsky [37]. We establish Markov duality relations and contour integral formulas for the $q$-Hahn PushTASEP. In a $q\to 1$ limit of our process we arrive at a random recursion, which, in a special case, appears to be similar to the inverse-Beta polymer model. However, unlike in recursions for Beta polymer models, the weights (i.e., the coefficients of the recursion) in our model depend on the previous values of the partition function in a nontrivial manner.
Effect of Integrating the Entomopathogenic Fungus (Hypocreales: Cordycipitaceae) and the Rove Beetle (Coleoptera: Staphylinidae) in Suppressing Western Flower Thrips (Thysanoptera: Thripidae) Populations Under Greenhouse Conditions
Authors: Li Yinping , Cloyd Raymond A , Bello Nora M 
Published: April 2019

AbstractWestern flower thrips, Frankliniella occidentalis (Pergande), is a destructive insect pest in greenhouse production systems. Therefore, integrating the entomopathogenic fungus, Beauveria bassiana (Balsamo) Vuillemin, with the soil-dwelling rove beetle, Dalotia coriaria (Kraatz), targeting different aboveground and belowground life stages may help effectively manage western flower thrips populations. Two greenhouse experiments were conducted evaluating five treatments: 1) insecticides (spinosad, pyridalyl, chlorfenapyr, and abamectin), 2) B. bassiana, 3) D. coriaria, 4) B. bassiana and D. coriaria combination, and 5) water control. The estimated mean number of western flower thrips adults captured on yellow sticky cards was significantly lower for the insecticide treatment (mean range: 0–46 western flower thrips adults per yellow sticky card) than the B. bassiana and D. coriaria combination (0.3–105.1 western flower thrips per yellow card) over 8 wk. There were no significant differences in the final foliar damage ratings of chrysanthemum, Dendranthema × grandiflorum (Ramat.) Kitam., plants among the five treatments in experiment 1, but there were significant differences in experiment 2. In experiment 2, chrysanthemum plants across all treatments were not marketable due to western flower thrips feeding damage. Therefore, using B. bassiana and D. coriaria early in production should suppress population growth by targeting both foliar-feeding and soil-dwelling life stages of western flower thrips simultaneously.
Delineating caveats for (quality) education during displacement: Critiquing the impact of forced migration on access to education
Authors: Benhura Abigail Rudorwashe , Naidu Maheshvari 
Published: April 2019

Abstract
This qualitative article aims at unraveling the impact of displacement on the access to (quality) education. The article is premised on the inherent role played by education to equip displaced children with functional skills and act as a liberating force in the face of forced displacement. Using purposive homogeneous sampling from Hopley and Caledonia settlements for internally displaced people (Zimbabwe), the article attempts to evaluate effects of displacement on the quality of education or access thereof. The article uses inter-textuality as a method to complement empirical evidence with reviewed literature. The Capability Approach is applied to assess the implications of forced migration on the provision of (quality) education. In terms of the Capability Approach, quality education is measured through the actual achievements realised by any human being who has been exposed to it (education). Therefore, the Capability Approach posits that every human being has the inherent potential to be who they aspire to be when exposed to a conducive environment. In the context of this article, access to quality education is an enabling environment. The findings indicate that displacement is invariably detrimental to the provision of quality education. Moreover, this condition enhances the vulnerabilities of forced migrants as education is critical, instrumental, and of intrinsic value to the socio-economic development of its recipients. This being so, the impact of displacement on internally displaced persons’ access to quality education is a topical issue worthy of discussion so as to chart relevant solutions to the varying contexts of displacement.
Detection of extensive optical emission from the extremely radio faint Galactic supernova remnant G182.4+4.3
Authors: Fesen Robert A , Neustadt Jack M M , How Thomas G , Black Christine S 
Published: April 2019

Abstract
Wide-field H α images of the radio faint Galactic supernova remnant G182.4+4.2 reveal a surprisingly extensive and complex emission structure, with an unusual series of broad and diffuse filaments along the remnant’s south-western limb. Deep [O iii] 5007 Å images reveal no appreciable remnant emission with the exception of a single filament coincident with the westernmost of the broad south-west filaments. The near total absence of [O  iii] emission suggests the majority of the remnant’s optical emission arises from relatively slow shocks (≤70 km s−1), consistent with little or no associated X-ray emission. Low-dispersion optical spectra of several regions in the remnant’s main emission structure confirm a lack of appreciable [O iii] emission and indicate [S  ii]/Hα line ratios of 0.73–1.03, consistent with a shock-heated origin. We find G182.4+4.2 to be a relatively large (d ∼ 50 pc at 4 kpc) and much older (age ∼ 40 kyr) supernova remnant than previously estimated, whose weak radio and X-ray emissions are related to its age, low shock velocity, and location in a low-density region some 12 kpc out from the Galactic Centre.
Cosmic ray transport and radiative processes in nuclei of starburst galaxies
Authors: Peretti Enrico , Blasi Pasquale , Aharonian Felix , Morlino Giovanni 
Published: April 2019

AbstractThe high rate of star formation and supernova explosions of starburst galaxies make them interesting sources of high-energy radiation. Depending on the level of turbulence present in their interstellar medium, the bulk of cosmic rays produced inside starburst galaxies may lose most of their energy before escaping, thereby making these sources behave as calorimeters, at least up to some maximum energy. Contrary to previous studies, here we investigate in detail the conditions under which cosmic ray confinement may be effective for electrons and nuclei and we study the implications of cosmic ray confinement in terms of multifrequency emission from starburst nuclei and production of high-energy neutrinos. The general predictions are then specialized to three cases of active starbursts, namely, M82, NGC 253, and Arp220. Both primary and secondary electrons, as well as electron–positron pairs produced by gamma-ray absorption inside starburst galaxies are taken into account. Electrons and positrons produced as secondary products of hadronic interactions are found to be responsible for most of the emission of leptonic origin. In particular, synchrotron emission of very high energy secondary electrons produces an extended emission of hard X-rays that represents a very interesting signature of hadronic process in starburst galaxies, potentially accessible to current and future observations in the X-ray band. A careful understanding of both the production and absorption of gamma-rays in starburst galaxies is instrumental to the assessment of the role of these astrophysical sources as sources of high-energy astrophysical neutrinos.
Occlusion Rate and Visual Complications With Flow-Diverter Stent Placed Across the Ophthalmic Artery's Origin for Carotid-Ophthalmic Aneurysms: A Meta-Analysis
Authors: Touzé Romain , Gravellier Bastien , Rolla-Bigliani Claudia , Touitou Valérie , Shotar Eimad , Lenck Stéphanie , Boch Anne-Laure , Degos Vincent , Sourour Nader-Antoine , Clarençon Frédéric 
Published: April 2019

Abstract

BACKGROUND
Flow-diverter stents (FDSs) have recently gained acceptance for the treatment of intracranial aneurysms, especially for carotid-ophthalmic aneurysms (COAs). However, complications have been reported after coverage of side branches, especially the ophthalmic artery (OA).

OBJECTIVE
To evaluate, through a meta-analysis, the occlusion rate, and the ophthalmic complications after treatment of COA by FDS.

METHODS
We reviewed on MEDLINE via PubMed, Embase via Ovid, and Cochrane central database via CENTRAL. We included all case series with at least 15 patients and clinical trials about flow diversion of aneurysms close to the OA’s origin. Among these studies, we only included articles with aneurysm occlusion rate and rate of new ophthalmic symptoms.

RESULTS
We included 16 studies with 913 COA treated by FDSs and covering the OA with a mean follow-up of 16.4 mo. The random-effect modeling analysis concerning the overall rate of new ophthalmic complications, after FDS deployment covering the OA, was 3.0% (CI95% 1.0-6.0). There was medium-high heterogeneity in the study reports P < .01, I2 = 70.2% [50.4%; 82.1%]. We were not able to statistically explain this heterogeneity with the performed analysis, which could be related to the design of the included studies. We found an overall aneurysm occlusion rate of 85.0% (95% CI 80.0-89.0).

CONCLUSION
Our meta-analysis found a high aneurysm occlusion rate (85%) and low rate of iatrogenic visual complications, with only 3.0% of new visual symptoms, after treatment of COA by FDS.
Consumption Network Effects
Authors: De Giorgi Giacomo , Frederiksen Anders , Pistaferri Luigi 
Published: April 2019

AbstractIn this article we study consumption network effects. Does the consumption of our peers affect our own consumption? How large is such effect? What are the economic mechanisms behind it? We use administrative panel data on Danish households to construct a measure of consumption based on tax records on income and assets. We combine tax record data with matched employer–employee data to identify peer groups based on workplace, which gives us a much tighter and credible definition of networks than used in previous literature. We use the non-overlapping network structure of one’s peers group, as well as firm-level shocks, to build valid instruments for peer consumption. We estimate non-negligible and statistically significant network effects, capable of generating sizable multiplier effect at the macro-level. We also investigate what mechanisms generate such effects, distinguishing between intertemporal and intratemporal consumption effects as well as a more traditional risk sharing view.
Tracking Progress Toward Elimination of Mother to Child Transmission of HIV in Zambia: Findings from the Early Infant Diagnosis of HIV Program (2009–2017)
Authors: Mutanga Jane N , Mutembo Simon , Ezeamama Amara E , Fubisha Robert C , Sialondwe Derrick , Simuchembu Brenda , Mutukwa Macwani , Chinyonga Jelita , Thuma Philip E , Whalen Christopher C 
Published: April 2019

Abstract

Background
We carried out analyses of early infant testing results at Livingstone Central Hospital in Zambia to assess time of testing, linkages to care and availability of test results for clinical decision making.

Methods
We abstracted data from registers of HIV-exposed infants who had dried blood spots cards (DBS) collected for DNA-PCR from January 2009 to December 2017. Only those tested from 2014 to 2017 had additional data which were used to estimate risk factors for mother-to-child HIV transmission using logistic regression models.

Results
DBS were collected from 2630 children. The proportion of HIV-positive tests decreased from 21% in 2009 to 2% in 2016 and 2017. Median turnaround time for results was 9 weeks (IQR: 5, 15) for HIV-negative, 7 weeks (IQR: 5, 13) for HIV-positive children. Only 2% of infants whose mothers took antiretroviral therapy (ART) were HIV positive, while 18% of infants whose mothers took short course antiretroviral drugs (ARVs) were infected. Infants of mothers who did not take ARVs had 9 times the odds of an HIV positive test (OR = 8.9, 95% CI: 3.6, 22.6). Infants of mothers who received short course ARVs were 40% less likely to get an HIV test within the first 2 months of life (OR = 0.6, 95% CI: 0.4, 0.9) compared to infants of mothers who received ART. Only 52% had a third test at median age 52 weeks (IQR: 50, 54).

Conclusions
Long turnaround time for test results and low retention in care after the initial HIV test were critical challenges to clinical decision making.
Congenital absence of the pericardium
Authors: Elbadawi Ayman , Baig Basarat , Alotaki Erfan , Khalid Heena , Khan Muhammad 
Published: April 2019

ABSTRACT
This article describes a patient who presented to the ED after multiple episodes of syncope. His physical examination was unremarkable and an initial workup was negative. Transthoracic echocardiography and chest CT confirmed the diagnosis of congenital complete absence of the pericardium, a rare developmental abnormality most common in men.
Addressing transgender patients' barriers to access care
Authors: Rowe Denise , Ng Yeow Chye , O'Keefe Louise C. 
Published: April 2019

Abstract:
The transgender population faces several barriers to accessing quality medical care in the US healthcare system. This article examines the challenges that prevent this marginalized group from obtaining high-quality healthcare services and discusses how NP advocacy can help create a welcoming environment for transgender patients.