bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolution of hyperinsulinemic hypoglycemia following partial pancreatectomy in a dog with nesidioblastosis
Authors: Polansky Benjamin J. , Martinez Stephen A. , Chalkley Mark D. 
Published: September 2018

Abstract
CASE DESCRIPTION A 6-year-old castrated male Australian Shepherd was evaluated because of a recent onset of persistent hypoglycemia.
CLINICAL FINDINGS Physical examination results were generally unremarkable. No abnormalities were detected on thoracic radiographs, and abdominal ultrasonography revealed no obvious pancreatic lesion. Hematologic analysis revealed hypoglycemia with a high serum insulin-to-glucose concentration ratio.
TREATMENT AND OUTCOME Insulinoma was suspected; medical treatment with prednisone was initiated, and exploratory laparotomy was performed. No pancreatic lesions or masses were observed. Partial left pancreatectomy and hepatic and local lymph node biopsies were performed. Histologic examination revealed islet cell hypertrophy and hyperplasia, with no evidence of neoplasia. Results of a PCR assay of the pancreatic tissue for Bartonella infection were negative. Clinical, biochemical, and histopathologic findings were compatible with nesidioblastosis. The clinical signs, including hypoglycemia, resolved after surgery. On follow-up examination 8 months later, the dog was apparently healthy and results of a CBC and serum biochemical analysis, including blood glucose concentration, were within respective reference ranges.
CLINICAL RELEVANCE To our knowledge, this is the first report of nesidioblastosis in a dog for which clinical signs and clinicopathologic abnormalities resolved after partial pancreatectomy. Although extremely rare, nesidioblastosis should be considered a differential diagnosis in dogs with signs suggestive of insulinoma.
Minimally invasive, compartmentalized, modified open castration technique with primary closure in equids
Authors: Crosa Albert Torrent , Desjardins Marc R. 
Published: September 2018

Abstract
OBJECTIVE To describe use of a modified open castration technique with a scrotal approach and primary closure in equids.
DESIGN Prospective case series.
ANIMALS 38 client-owned, sexually intact male equids.
PROCEDURES With owner consent, elective castration was performed with a modified open technique on patients (1 pony, 1 miniature horse, and 36 horses of other breeds) under general anesthesia. The procedure included minimal dissection into the scrotal region for removal of testes, with cremaster muscles left intact and the parietal vaginal tunic closed in place. Primary closure of surgical wounds was performed. Patients were monitored for signs of complications. Signalment, surgery-related variables, results of ultrasonographic imaging, postoperative treatments, and outcomes were recorded. Follow-up information was obtained from owners ≥ 6 months after surgery. Medical records were reviewed, and descriptive data were reported.
RESULTS Median anesthesia and surgery times were 113.5 and 60 minutes, respectively. Duration of hospitalization ranged from 1 to 3 days. No intraoperative complications were observed. Postoperative complications (moderate swelling in the scrotal region) developed in 2 of 38 (5%) patients. Mild scrotal swelling (n = 5) and transient pyrexia (typically mild; 9) also occurred; no patients had signs of postoperative bleeding, infection, or colic. All equids gradually returned to exercise beginning 10 days after the procedure. Cosmetic results were considered excellent.
CONCLUSIONS AND CLINICAL RELEVANCE The modified castration technique was considered simple to perform and advantageous because of the low complication rate, excellent cosmetic results, and prompt return to intended use after surgery.
Effect of different treatment on the proximate and antinutritional content of Nigerian cashew apple residue
Authors: Akinnibosun Faith Iguodala , Oyetayo Adedayo Michael 
Published: September 2018

Abstract
In this study, cashew apple residue (CAR) was subjected to various treatments (boiling, soaking and fermentation), thereafter, proximate composition and anti-nutrient content were determined. Fermentation significantly (p < 0.05) increased the protein content of the CAR by 56.07% and reduced the carbohydrate content to 42.49%. Moreover, soaking and fermentation significantly reduced phytate content of the CAR from 0.4123% to 0.2504% and 0.1106% respectively; all the treatments significantly reduced the oxalate content while boiling and soaking had a significant reducing effect on the tannin content of the CAR. These suggest that pre-treated cashew apple residue may be used for animal feed formulation.
Isolation and characterization of hydrocarbon-degrading fungi from Ogbe-Ijoh oil creek, Warri, Delta State, Nigeria
Authors: Akinnibosun Faith Iguodala , Ashegbare Abigail 
Published: September 2018

Abstract
This study was aimed at isolating and characterizing hydrocarbon-degrading fungi from hydrocarbon-contaminated soil in Ogbe-Ijoh oil creek in Warri, Delta State, Nigeria. Isolation and characterization were carried out using standard methods. Biodegradation assay was carried out over 25 days and monitored using the following parameters; pH, total organic carbon, and total hydrocarbon content. The fungi isolated were: Penicillium sp., Aspergillus niger and Fusarium sp., and these were used for the biodegradation study. Physico-chemical analysis of the crude oil contaminated soil during degradation showed that there was significant decrease in pH during degradation from day 10 - 25 (p ≥ 0.05). This showed the ability of the fungal isolates to utilize crude oil as carbon source, producing acid during its metabolism. The highest pH value during degradation by the fungal isolates was recorded in Fusarium sp. and the lowest was recorded in Aspergillus sp. The fungal isolates were able to reduce the total carbon and hydrocarbon content during degradation. This was probably due to the utilization of the nutrients in the soil sample as energy source. The results from this study indicate the potential of the isolated fungi for hydrocarbon bioremediation activity.
Synthesis and density-functional-theory calculations of electronic band structure of hollow sphere WS2
Authors: Akple Maxwell Selase , Apevienyeku Holali Kwami 
Published: September 2018

Abstract
A novel and low-cost synthesis of tungsten disulfide (WS2) transition metal dichalcogenide was carried out via gas-solid reaction in a horizontal quartz reactor. In this process, the prepared hollow WO3 precursor was sulfided with CS2 at 550 °C at different durations under N2 gas atmosphere. The as-prepared WS2 samples were formed by substitution of O by S during the sulfidation process. The characterization of these samples was performed employing X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray (EDX), Brunauer-Emmett-Teller (BET) specific surface area, X-ray photoelectron spectroscopy (XPS) and UV-Vis absorption spectroscopy. The characterization results showed that the as-prepared WS2 samples were of high quality and purity. No significant differences were observed in various WS2 samples synthesized during different sulfidation periods. The calculated results obtained from the density functional theory (DFT) indicate that WS2 has an indirect band gap of ca. 1.56 eV, which is in agreement with experimental band gap of ca. 1.50 eV. Combining the experimental and DFT results suggests that the novel method used in the synthesis of WS2 has a potential application for large scale production. The obtained WS2 are of high quality and can be implemented in photocatalysis, catalysis, photovoltaics, optoelectronic devices and photosensor devices.
Induction chemotherapy, chemoradiotherapy and consolidation chemotherapy in preoperative treatment of rectal cancer - long-term results of phase II OIGIT-01 Trial
Authors: Golo Danijela , But-Hadzic Jasna , Anderluh Franc , Brecelj Erik , Edhemovic Ibrahim , Jeromen Ana , Omejc Mirko , Oblak Irena , Secerov-Ermenc Ajra , Velenik Vaneja 
Published: September 2018

Abstract

Background
The purpose of the study was to improve treatment efficacy for locally advanced rectal cancer (LARC) by shifting half of adjuvant chemotherapy preoperatively to one induction and two consolidation cycles.

Patients and methods
Between October 2011 and April 2013, 66 patients with LARC were treated with one induction chemotherapy cycle followed by chemoradiotherapy (CRT), two consolidation cycles, surgery and three adjuvant capecitabine cycles. Radiation doses were 50.4 Gy for T2-3 and 54 Gy for T4 tumours in 1.8 Gy daily fraction. The doses of concomitant and neo/adjuvant capecitabine were 825 mg/m2/12h and 1250mg/m2/12h, respectively. The primary endpoint was pathologic complete response (pCR).

Results
Forty-three (65.1%) patients were treated according to protocol. The compliance rates for induction, consolidation, and adjuvant chemotherapy were 98.5%, 93.8% and 87.3%, respectively. CRT was completed by 65/66 patients, with G ≥ 3 non-hematologic toxicity at 13.6%. The rate of pCR (17.5%) was not increased, but N and the total-down staging rates were 77.7% and 79.3%, respectively. In a median follow-up of 55 months, we recorded one local relapse (LR) (1.6%). The 5-year disease-free survival (DFS) and overall survival (OS) rates were 64.0% (95% CI 63.89–64.11) and 69.5% (95% CI 69.39–69.61), respectively.

Conclusions
In LARC preoperative treatment intensification with capecitabine before and after radiotherapy is well tolerated, with a high compliance rate and acceptable toxicity. Though it does not improve the local effect, it achieves a high LR rate, DFS, and OS.
Epidemiology of oral mucosal lesions in Slovenia
Authors: Kansky Andrej Aleksander , Didanovic Vojko , Dovsak Tadej , Brzak Bozana Loncar , Pelivan Ivica , Terlevic Diana 
Published: September 2018

Abstract

Background
Among the diseases of oral mucosa, malignant tumors are the most dangerous, but not the most common lesions that might appear in the oral cavity. Since most of the studies are focused on the detection of cancer in the oral cavity, we were interested in detecting the frequency of benign changes of the oral mucosa in Slovene population. Oral mucosal lesions are important pointer of oral health and quality of life, especially in elderly. The prevalence of oral mucosal lesions, together with information on the risk habits associated with oral health, such as tobacco and alcohol use, can help in planning future oral health studies and screening programs.

Patients and methods
Survey upon oral mucosal lesions was conducted during the national project for oral cancer screening in spring 2017 in the Slovenia in which more than 50% of dentists participated and 2395 patients (904 men and 1491 women) were included.

Results
Clinical examination, which was conducted according to the WHO standards revealed that 645 patients (27%) had oral mucosal lesions. The ten most common oral lesions detected were fibroma, gingivitis, Fordyce spots, white coated tongue, cheek biting, linea alba, denture stomatitis, geographic tongue, recurrent aphthous ulcerations and lichen planus.

Conclusions
Overall, these epidemiological data suggest need for specific health policies for prevention, diagnosis and treatment of oral mucosal lesions.
Three-dimensional ultrasound evaluation of tongue posture and its impact on articulation disorders in preschool children with anterior open bite
Authors: Kravanja Sanda Lah , Hocevar-Boltezar Irena , Music Maja Marolt , Jarc Ana , Verdenik Ivan , Ovsenik Maja 
Published: September 2018

Abstract

Background
Tongue posture plays an important role in the etiology of anterior open bite (AOB) and articulation disorders, and is crucial for AOB treatment planning and posttreatment stability. Clinical assessment of tongue posture in children is unreliable due to anatomical limitations. The aim of the study was to present functional diagnostics using three-dimensional ultrasound (3DUS) assessment of resting tongue posture in comparison to clinical assessment, and the associations between the improper tongue posture, otorhinolaryngological characteristics, and articulation disorders in preschool children with AOB.

Patients and methods
A cross-sectional study included 446 children, aged 3–7 years, 236 boys and 210 girls, examined by an orthodontist to detect the prevalence of AOB. The AOB was present in 32 children. The control group consisted of 43 children randomly selected from the participants with normocclusion. An orthodontist, an ear, nose and throat (ENT) specialist and a speech therapist assessed orofacial and ENT conditions, oral habits, and articulation disorders in the AOB group and control group. Tongue posture was also assessed by an experienced radiologist, using 3DUS. The 3DUS assessment of tongue posture was compared to the clinical assessment of orthodontist and ENT specialist.

Results
The prevalence of AOB was 7.2%. The AOB group and the control group significantly differed regarding improper tongue posture (p < 0.001), and articulation disorders (p < 0.001). In children without articulation disorders from both groups, the improper tongue posture occured less frequently than in children with articulation disorders (p < 0.001). After age adjustment, a statistical regression model showed that the children with the improper tongue posture had higher odds ratios for the presence of AOB (OR 14.63; p < 0.001) than the others. When articulation disorders were included in the model, these odds ratios for the AOB became insignificant (p = 0.177). There was a strong association between the improper tongue posture and articulation disorders (p = 0.002). The 3DUS detected the highest number of children with improper resting tongue posture, though there was no significant difference between the 3DUS and clinical assessments done by orthodontist and ENT specialist.

Conclusions
The 3DUS has proved to be an objective, non-invasive, radiation free method for the assessment of tongue posture and could become an important tool in functional diagnostics and early rehabilitation in preschool children with speech irregularities and irregular tongue posture and malocclusion in order to enable optimal conditions for articulation development.
Case report: Life-saving pulmonary endarterectomy for a young female with primary antiphospholipid syndrome complicated by severe chronic thromboembolic pulmonary hypertension
Authors: Palevičiūtė Eglė , Malickaitė Radvilė , Matačiūnas Mindaugas , Šileikienė Virginija , Kryžauskaitė Lina , Širmenis Raimundas , Karalius Rimantas , Gumbienė Lina 
Published: September 2018

Abstract
Background: Prothrombotic state and impaired clot dissolution can contribute to the occurrence of chronic thromboembolic pulmonary hypertension in primary antiphospholipid syndrome. Pulmonary endarterectomy - the surgical removal of the organized thromboembolic material from the proximal pulmonary arteries - is the procedure of choice and potentially a curative option for patients with chronic thromboembolic pulmonary hypertension, including patients with antiphospholipid syndrome. We report an exceptionally severe and complicated case with favourable outcome. Case presentation: We present a case of a successful high risk pulmonary endarterectomy in a 29-year-old female with primary antiphospholipid syndrome and end-stage chronic thromboembolic pulmonary hypertension. Despite highly complicated perioperative course an impressive improvement in symptoms and functional status was achieved. Conclusion: We hope that this complicated but successfully managed case of a combination of two rare diseases will arouse earlier suspicion and timely diagnosis for such patients and will encourage physicians to promptly refer the suitable patients to a pulmonary endarterectomy team. It is important to remember that severe thrombocytopenia may occur in patients with antiphospholipid syndrome
Review: The choice and cardiovascular safety of particular nonsteroidal anti-inflammatory drugs
Authors: Černeckis Jonas , Samuolytė Austėja , Baltušytė Greta , Ivanickaitė Rugilė , Puteikis Kristijonas 
Published: September 2018

Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are authorized for the relief of pain and inflammation in a wide range of conditions including the discomfort associated with headaches, osteoarthritis, rheumatoid arthritis, and menstrual pain and are available by prescription or over-the-counter (OTC). We reviewed common adverse effects of NSAIDs (especially those related to cardiovascular [CV] system) along with NICE (National Institute for Health and Care Excellence), EMA (European Medicines Agency), and the FDA (U.S. Food and Drug Administration) guidelines for safe and effective use of particular NSAIDs. Furthermore, we examined the NSAIDs market in Lithuania in a period between June 2016 and May 2017 and discussed how well recommendations mentioned above were followed. We emphasized that there was a high percentage of diclofenac prescribed in Lithuania while international guidelines encourage prescribing ibuprofen or naproxen for their relatively lower CV risk. Reviewing past trials, we observed that despite existing guidelines no single NSAID could be considered to be the safest one due to a lack of superiority trials
Nonradiographic Measurement of Hallux Valgus Angle Using Self-photography
Authors: Yamaguchi Satoshi , Sadamasu Aya , Kimura Seiji , Akagi Ryuichiro , Yamamoto Yohei , Sato Yasunori , Sasho Takahisa , Ohtori Seiji 
Published: September 2018

Background Radiographs of the feet are the reference standard for measuring the hallux valgus angle. However, the availability and use of radiographs are constrained due to cost and radiation exposure. Less invasive, nonradiographic assessments have been proposed, although measurement using self-photography has not been reported. Objectives To determine (1) reliability of photographic hallux valgus angle (pHVA) measurement using the same photographs of the feet, (2) reliability of repeated self-photography trials, and (3) measurement error when the radiographic hallux valgus angle (rHVA) is estimated using the pHVA. Methods In this reliability study, participants took photographs of their own feet using a digital camera. The intrarater and interrater reliability of pHVA measurements were then assessed using the intraclass correlation coefficient (ICC) and 95% minimum detectable change (MDC). The participants took photographs twice, and the reliability of repeated self-photography trials was examined. Participants also received radiographs of their feet, from which the rHVA was measured. The measurement error was assessed using the mean difference and 95% limits of agreement. Results The intrarater and interrater ICC of pHVA measurement was 0.99, with MDCs less than 2°. The ICC of pHVA measurement for repeated self-photography was 0.96, and the MDC was 6.9°. The pHVA was systematically lower than the rHVA, by 5.3°. Conclusion Measurement of the pHVA using self-photography was reproducible, although pHVA measurement underestimated the rHVA. The pHVA can be a useful nonradiographic method to quantify hallux valgus deformity. J Orthop Sports Phys Ther 2019;49(2):80–86. Epub 12 Sep 2018. doi: 10.2519/jospt.2019.8280
Exploratory Study of 6-Month Pain Trajectories in Individuals With Predominant Patellofemoral Osteoarthritis: A Cohort Study
Authors: Mills Kathryn , Eyles Jillian P. , Martin Michael A. , Hancock Mark J. , Hunter David J. 
Published: September 2018

Background Knowledge of patellofemoral osteoarthritis (OA) pain trajectories is vital to helping clinicians and patients make shared disease-specific decisions regarding treatment options and coping strategies. Objectives To describe the pain trajectories of people living with patellofemoral OA who present to a chronic care management program, and to explore baseline characteristics associated with different trajectories. Methods In this prospective longitudinal cohort study, 88 participants who presented to a chronic care management program reported their worst pain over the previous week at baseline and at 6, 12, 18, and 26 weeks using a 10-cm visual analog scale. Trajectories (classes) were identified using latent class growth analysis. Demographics, pain, physical performance, strength, quality of life, mental health, and lower limb/foot structural measures obtained at baseline were assessed for association with trajectory class membership. Results Individuals in class 1 (28%) exhibited high, persistent pain from baseline (7.8 ± 1.7 cm), which continued over time (P = .52). Class 2 (57%) displayed moderate baseline pain (4.8 ± 1.8 cm), which also remained persistent (P = .97). Individuals in class 3 (15%) showed low, improving pain (baseline pain, 2.6 ± 1.2 cm) over time (P = .017). At baseline, poor Knee injury and Osteoarthritis Outcome Score (KOOS) scores, local and proximal sensitivity to pressure, and lower knee extensor strength were associated with increased odds of following the high-pain trajectory (range [95% confidence interval], 1.03 [1.00, 1.07] to 16.24 [2.53, 104.34]). Conclusion Distinct pain trajectories appear to exist in people with patellofemoral OA presenting to a chronic care management program. Baseline variables may be useful for identifying individuals at risk of poorer prognosis. Larger studies are needed to confirm the efficacy of this finding. Level of Evidence Prognosis, level 2b. J Orthop Sports Phys Ther 2019;49(1):5–16. Epub 12 Sep 2018. doi:10.2519/jospt.2019.8354
PENGEMBANGAN BUKU CERITA BERBASIS PENDIDIKAN KARAKTER UNTUK MENINGKATKAN KREATIVITAS AUD
Authors: Miranda Dian 
Published: September 2018

Anak merupakan pembelajar yang penuh kejujuran dalam mengekspresikan perasaan dan imajinasinya. Terkait dengan imajinasi, pada dasarnya semua anak kreatif dimana menurut George & Zhou (dalam Ashkanasy & Rowe, 2008) kreativitas adalah suatu produk ide atau solusi yang bersifat baru dan berguna. Menurut munandar (2002) salah satu manfaat kreativitas ilah dapat meningkatkan kulitas hidup dan memecahkan masalah dari berbagai sudut pandang, oleh sebab itu kreativitas penting untuk diasah sejak dini, agar menjadi karakter yang melekat dalam diri anak. Namun perlu difahami bahwa kreativitas tidak hanya terkait dengan kebaruan, tetapi juga harus berguna. Oleh sebab itu, kreativititas tidak boleh semaunya dan harus dibatasi dengan kemampuan memilih hal yang baik dan buruk, bermanfaat atau tidak bermanfaat, atau bahkan berdampak negatif. Oleh sebab itu anak perlu untuk diarahkan mengenai cara mengekspresikan perasaan dan imajinasinya dengan benar sesuai dengan nilai dan norma yang diterima di masyarakat maupun agama. Dalam rangka upaya meningkatkan kemampuan kreativitas dan menanamkan nilai karakter anak, maka penelitian ini berusaha untuk merancang dan membuat sebuah media pembelajaran yang sesuai bagi anak yaitu sebuah buku cerita bergambar bermuatan pendidikan karakter dan juga dapat meningkatkan kreativitas anak. Metode yang digunakan dalam penelitian ini adalah metode research and development (R&D) dengan model prosedural, yaitu model yang bersifat deskriptif, yaitu menggariskan langkah-langkah yang harus diikuti untuk menghasilkan produk. Hasil yang didapat dari penelitian ini ialah buku cerita bergambar dinilai baik sebagai media penanaman karakter religius, toleransi, bersahabat, peduli sosial, disiplin, dan cinta damai serta baik digunakan sebagai media pengembang kreativitas anak usia dini khususnya anak usia 5-6 tahun.