bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of snow cover formation and melt with publication of the output data on the web map service (on the example of Kama river basin)
Authors: Pyankov S V , Kalinin N A , Shikhov A N , Abdullin R K , Bykov A V 
Published: September 2019

Abstract
It is performed an assessment of the use of daily precipitation forecasts of global numerical weather prediction (NWP) models GFS (U.S.), GEM (Canada), SLAV (Russia) and ICON (Germany) as input data for snow accumulation and melt modelling in the Kama river basin for two cold seasons. It is shown, that maximum snow water equivalent (SWE) calculated on the basis of NWP models output has an error less than 27% of the measured values, in the conditions of 2017-2018 snow accumulation season. However, this is preliminary assessment, which requires verification by several seasons. It is rather difficult to conclude which model provides highest accuracy of SWE calculation, because each of them has its specific limitations. In 2018-2019 cold season, we additionally obtained ICON model data, which provides the most accurate forecast of precipitation. The simulated SWE and meltwater outflow data are published on the online web map service.
The role of precipitation and air temperature in the formation of summer runoff
Authors: Akmatov R T , Alamanov S K , Choduraev T M 
Published: September 2019

Abstract
This article focuses on the analysis of the formation of river flow in the summer period, in which there is the greatest need for water to meet agricultural needs and there is the maximum contribution of glacier water to the total flow. To identify the influence of air temperature and precipitation in different summer months and in general for June-August, calculated were correlation coefficients between climate elements and the water content of watercourses. The steady dependence of the runoff on air temperature, both for individual months and the summer period, is generally characteristic only of the Chon and Kichi Naryn river basins.
Formation of bottom sediments in valley reservoirs and its research methods
Authors: Koviazina I A , Kalinin V G 
Published: September 2019

Abstract
The paper presents a review of studies by Russian and foreign scientists on the formation of bottom sediments in valley reservoirs. The typing of the main factors according to the time of occurrence and the source of income was carried out. Methods for studying the processes of bottom sediments formation are identified. This is an assessment of the material collapsed volume at coastal stations, the calculation of the solid flow in the main tributaries, sampling of bottom soil, repeated depth measurements. The organization of comprehensive studies of the input and expenditure components of the sedimentation balance and modelling of spatial and temporal changes in the bottom relief using GIS-technologies is important for predicting the siltation of reservoirs.
Analysis of the dependencies of spring flood runoff from the main factors
Authors: Kalinin V G , Mekhanoshina E V 
Published: September 2019

Abstract
The article is devoted to study of the conditions of the spring flood runoff formation in high water years. The authors analysed the dependences of the runoff layer on the main factors such as the maximum water storage in the snow before the beginning snowmelt, sum of the positive air temperatures, sum of the precipitation during the spring flood and autumn moistening. It was revealed that the determining factors in the formation of the spring flood runoff layer on the rivers of the Votkinsk catchment are the maximum water reserve in snow and precipitation that fell during this period.
Formation of the hydrochemical regime of Lake Zuratkul
Authors: Zakharov S G 
Published: September 2019

Abstract
The changes in the hydrochemical state of the water masses of the lake-reservoir Zyuratkul for the period 1966 - 2018 are considered. on the concentration of the main water ions, nitrogen and phosphorus compounds, oxidability, some hydrophysical parameters (transparency, chromaticity). Conclusions about cyclical and evolutionary change of individual parameters and characteristics of water masses are made. Defined modern water quality in the reservoir.
Long-term dynamics of hydrobiont communities in Kenon Lake
Authors: Bazarova B B , Kuklin A P , Matafonov P V , Tsybekmitova G Ts , Gorlacheva E P , Afonina E Yu , Tashlykova N A 
Published: September 2019

Abstract
Long-term researches of Kenon Lake, that exploited the lake as a cooling reservoir of the Chita thermoelectric plant-1, have revealed that composition of the dominating system of hydrobiont and fish communities of the lake has no significant variations. Maintenance of the lake level at the expense of pumping water from Ingoda River leads to flatness of processes taking place in the ecosystem and possibilities for the ecosystem state regulation.
Comparative characteristic of plankton microbial community in the waterway and coastal areas of the Kama reservoirs cascade
Authors: Tarasova N G , Bykova S V , Gorbunov M Yu , Krasnova E S , Umanskaya M V 
Published: September 2019

Abstract
The comparative analysis of indicators of development of various components of plankton community in reservoirs of the Kama cascade in various hydrological seasons, and on various sites (in coastal and waterway) was carried out. The difference in the quantitative development of unicellular pro- and eukaryotes in different areas (coastal and riverbed) was more pronounced than in different hydrological seasons (spring flood and summer low water). Cyanobacteria make the greatest contribution to the formation of the total biomass of phytoplankton in the waterway. The contribution of heterotrophic component (bacteria and ciliata) is more significant in the coastal area. It was shown the significant correlation of the biomass of unicellular plankton and picodetritus particles, which was present in considerable amounts in the waters of the Kama reservoirs cascade.
Conductivity and capacitance of streamers in avalanche model for streamer propagation in dielectric liquids
Authors: Madshaven I , Hestad OL , Unge M , Hjortstam O , Åstrand PO 
Published: September 2019

Abstract
Propagation of positive streamers in dielectric liquids, modeled by the electron avalanche mechanism, is simulated in a needle–plane gap. The streamer is modeled as an RC-circuit where the channel is a resistor and the extremities of the streamer have a capacitance towards the plane. The addition of the RC-model introduces a time constant to the propagation model. Increase in capacitance as a streamer branch propagates reduces its potential, while conduction through the streamer channel increases its potential, as a function of the time constant of the RC-system. Streamer branching also increases the capacitance and decreases the potential of the branches. If the electric field within the streamer channel exceeds a threshold, a breakdown occurs in the channel, and the potential of the streamer is equalized with the needle electrode. This is interpreted as a re-illumination. According to this model, a low conductive streamer branch can propagate some distance before its potential is reduced to below the propagation threshold, and then the RC time constant controls the streamer propagation speed. Channel breakdowns, or re-illuminations, are less frequent when the channels are conductive and more frequent for more branched streamers.
Oxytocin-induced prostaglandin F2-alpha release is low in early bovine pregnancy but increases during the second month of pregnancy†
Authors: Drum Jéssica N , Wiltbank Milo C , Monteiro Pedro L J , Prata Alexandre B , Gennari Rodrigo S , Gamarra Caio A , Canavessi Aurea M O , Sartori Roberto 
Published: September 2019

Abstract
Circulating prostaglandin F2α metabolite (PGFM) after an oxytocin challenge was evaluated throughout the first 2 months of pregnancy in lactating Holstein cows. On day 11, 18, and 25 after artificial insemination (AI), and on days 32, 39, 46, 53, and 60 of pregnancy, cows were challenged with 50 IU oxytocin, i.m. Blood was collected before (0 min), 30, 60, 90, and 120 min after oxytocin for plasma PGFM concentrations. Ultrasound evaluations were performed for pregnancy diagnosis on day 32–60 post-AI. Nonpregnant (NP) cows on day 18 were designated by a lack of interferon-stimulated genes in peripheral blood leukocytes and Pregnant (P) based on day 32 ultrasound. On day 11, P and NP were similar with low PGFM and no effect of oxytocin on PGFM. On day 18, oxytocin increased PGFM (3-fold) in NP with little change in P cows. Comparing only P cows from day 11 to 60, basal circulating PGFM increased as pregnancy progressed, with day 11 and 18, lower than all days from day 25 to 60 of pregnancy. Oxytocin-induced PGFM in P cows on day 25 was greater than P cows on day 18 (2.9-fold). However, oxytocin-induced PGFM was lower on day 25 compared to day 53 and 60, with intermediate values on day 32, 39, and 46 of pregnancy. Thus, the corpus luteum (CL) of early pregnancy (day 11, 18) is maintained by suppression of PGF, as reflected by suppressed PGFM in this study. However, during the second month of pregnancy, uterine PGF secretion was not suppressed since basal PGFM and oxytocin-induced PGFM secretion were elevated. Apparently, mechanisms other than suppression of oxytocin receptors maintain CL after day 25 of pregnancy.
Combination Lorcaserin and Nicotine Patch for Smoking Cessation Without Weight Gain
Authors: Rose Jed E , Davis James M 
Published: August 2019

Abstract

Introduction
This study explored the efficacy of combination lorcaserin and nicotine patch for smoking cessation treatment and prevention of postsmoking cessation weight gain.

Methods
We conducted a trial in which 61 adult daily smokers were asked to quit smoking using a combination of lorcaserin and nicotine patch. During the first 2 weeks of treatment prior to the quit day, participants were randomized to receive either lorcaserin (10 mg twice daily) plus nicotine patch (21 mg) or placebo plus nicotine patch (21 mg). Following this 2-week period, participants received both medications for 12 weeks. Outcomes included 4-week continuous smoking abstinence at the end of treatment (weeks 7–10 postquit attempt), weight change, ad libitum smoking, withdrawal symptoms, and ratings of cigarette reward.

Results
Biochemically confirmed continuous smoking abstinence from 7 to 10 weeks postquit attempt was 31.1% (90% confidence interval, 21.4%–40.8%). Participants who quit smoking showed no weight gain; in fact, mean weight change was minus 0.16 kg (SD = 3.27) over the study period. There was an unexpected but strong association (p = .006) between a decrease in sensory enjoyment of smoking and successful quit outcome on this regimen. During the prequit randomization period, lorcaserin versus placebo reduced the impact of smoking to relieve craving for cigarettes as well as the sensory enjoyment of smoking (p = .005). Adherence and tolerability to lorcaserin and nicotine patch was good.

Conclusions
The combination of lorcaserin and nicotine patch was well tolerated, associated with a relatively high smoking abstinence rate, and effectively prevented weight gain associated with quitting smoking.

Implications
This report provides an important contribution to the literature because it details evidence of a medication combination—lorcaserin and nicotine—that is effective for smoking cessation and for ameliorating weight gain associated with smoking cessation. For many smokers, postcessation weight gain is a major obstacle to quitting, and this medication combination provides a suitable treatment option for these smokers.

Clinical Trial Registration
NCT02906644
Gastrointestinal Adverse Events Observed After Chimeric Antigen Receptor T-Cell Therapy
Authors: Abu-Sbeih Hamzah , Tang Tenglong , Ali Faisal S. , Luo Wenyi , Neelapu Sattva S. , Westin Jason R. , Okhuysen Pablo C. , Foo Wai Chin , Curry Jonathan L. , Richards David M. , Ge Phillip S. , Wang Yinghong 
Published: September 2019

Background:
Chimeric antigen receptor T-cell (CART) therapy can significantly improve outcomes for patients with certain hematologic malignancies. The most notable drawbacks of CART are cytokine release syndrome and CART-related encephalopathy syndrome. Gastrointestinal adverse events (GI-AEs) have not yet been reported in association with CART. Herein, we describe the incidence and clinical features of GI-AEs observed after CART.

Materials and Methods:
We report a case series of patients with hematologic malignancies who received CART, in a clinical trial or as the standard of care, and subsequently suffered from GI-AEs between 2012 and 2018.

Results:
In our cohort, 37 of 132 (28%) patients experienced GI-AEs. All 37 experienced diarrhea with a median onset of 7 days (interquartile range, 4 to 25 d) after CART infusion. The median age of these patients was 58 years. Most had diffuse large B-cell lymphoma (51%). Seventeen patients experienced cytokine release syndrome, and 9 experienced CART-related encephalopathy syndrome. The interleukin-6 antagonist was required in 15 patients. Overall, 49% of patients had grade 1 diarrhea, 32% had grade 2, and 15% had grade 3. Other gastrointestinal symptoms in these patients were abdominal pain (41%), nausea and vomiting (49%), fever (8%), bloody stools (3%), and abdominal distension (5%). The median duration of symptoms was 6 days (interquartile range, 3 to 9 d). In 32 patients who underwent imaging, 8 (25%) had findings suggestive of gastrointestinal tract inflammation. Nine (24%) patients experienced GI-AE recurrence after initial improvement. The symptoms were attributed to an alternative cause in 17 (13%) cases and to CART in 20 (15%) cases. One patient developed CART-related refractory colitis that eventually responded to antibiotics for pneumonia.

Conclusion:
CART-related GI-AEs occur in 15% of patients treated with CART. These symptoms are typically mild and self-limiting, requiring only symptomatic treatment. Nevertheless, CART may, in rare cases, lead to refractory colitis.
Air pollution, maternal hypertensive disorders, and preterm birth
Authors: Weber Kari A. , Yang Wei , Lurmann Frederick , Hammond S. Katharine , Shaw Gary M. , Padula Amy M. 
Published: September 2019

Background:
Air pollution has been associated with hypertension and preterm birth. We examined if prenatal exposure to air pollutants was associated with gestational hypertension and if its association with preterm birth was modified by maternal hypertension.

Methods:
Data were from birth certificates and hospital discharge records of 252,205 women in San Joaquin Valley of California from 2000 to 2006. Air quality data were assigned from 24-hour averages of nitrogen dioxide (NO2), particulate matter <10µm (PM10) and <2.5µm (PM2.5), and carbon monoxide (CO) for different averaging periods over pregnancy. We estimated odds of preterm birth and multiplicative interaction between each pollutant and hypertensive disorder.

Results:
Among normotensive women, odds of preterm birth were slightly higher for higher exposure to all pollutants over the entire pregnancy. Patterns were similar among women with a hypertensive disorder. Among 32–36 week births, there was effect modification for exposure to NO2 and CO during the first trimester with higher odds among hypertensive women, and PM2.5 and CO during the last 6 weeks with higher odds among normotensive women. For 28–31 week births, there was effect modification by hypertensive status for PM10 exposure for the entire pregnancy, first, and second trimester with hypertensive women consistently having lower odds of preterm birth than normotensive.

Conclusion:
There was some evidence of effect modification in the direction counter to our hypothesis for exposure to PM10 and early preterm birth, and CO and PM2.5 at the end of pregnancy, but overall, hypertension did not modify the relationship between pollution and preterm birth.
Residential greenness, activities of daily living, and instrumental activities of daily living
Authors: Zhu Anna , Yan Lijing L. , Wu Chih-Da , James Peter , Zeng Yi , Ji John S. 
Published: September 2019

Background:We aimed to explore whether higher levels of residential greenness were related to lower odds of disabilities in activities of daily living (ADL) and instrumental activities of daily living (IADL).Methods:We included older adults 65 years of age or older from the Chinese Longitudinal Healthy Longevity Survey. Our exposure was Normalized Difference Vegetation Index in 500 m radius around residence. Our outcome was ADL and IADL. We used binary logistic regression and mixed-effects logistic regression to estimate the odds of ADL and IADL disabilities.Results:A total of 36,803 and 32,316 participants were included for the analysis of ADL and IADL, with 71.6% free of ADL disability and 47.3% free of IADL disability. In the logistic regression model, compared with the participants living in the lowest quartile of residential greenness, those in the highest quartile had a 28% (odds ratio [OR] = 0.72; 95% confidence interval [CI] = 0.65, 0.79) lower odds of ADL disability and a 14% (OR = 0.86; 95% CI = 0.77, 0.95) lower odds of IADL disability. A similar association was found in the mixed-effects logistic regression models. During the follow-up period, 5,004 and 4,880 healthy participants developed ADL and IADL disabilities. Per 0.1-unit increase in baseline annual average Normalized Difference Vegetation Index (NDVI) was related to an OR of 0.95 of developing ADL disability (95% CI = 0.93, 0.98) and IADL disability (95% CI = 0.91, 0.98).Conclusions:Our study suggests that increasing green space is associated with lower odds of ADL and IADL disabilities, which may reduce caregiver burden of long-term care for Chinese older adults.
Limited Sampling Strategies Supporting Individualized Dose Adjustment of Intravenous Busulfan in Children and Young Adults
Authors: Teitelbaum Zvi , Nassar Laila , Scherb Inna , Fink Dorit , Ring Gil , Lurie Yael , Krivoy Norberto , Bentur Yedidia , Efrati Edna , Kurnik Daniel 
Published: September 2019

Background:
Therapeutic drug monitoring (TDM) for busulfan supports dose adjustment during conditioning for stem cell transplantation. The authors aimed to develop and validate limited sampling strategies (LSS) of 4–5 samples for a precise estimation of the area under concentration (AUC)-time curve of busulfan, in plasma as an alternative to an intensive sampling strategy (ISS) requiring 9–10 samples.

Methods:
ISS TDM data from 297 patients (≤18 years of age) were used. AUCLSS was calculated using the trapezoidal rule and multiple linear regression (MLR). Unlike more complex modeling methods, MLR does not require sophisticated software or advanced training of personnel. MLR coefficients were estimated in the development subset containing randomly selected 50% of the records and were then used to calculate the AUCLSS of the remaining records (the validation subset). The agreement between dose adjustment recommendations (DAR) based on ISS and LSS, in the validation subset, was evaluated by a Bland–Altman analysis. A DAR deviating from an ISS-based reference by <15% was deemed acceptable.

Results:
Twelve LSSs were acceptable. Sampling at 0, 120, 180, and 240 minutes after the start of the second infusion (LSS15) yielded the best performance, with DAR deviating from the reference by <10% for 95% of cases; the AUCLSS was determined as follows: AUCLSS = 74.7954 × C(0) + 81.8948 × C(120) + 38.1771 × C(180) + 138.1404 × C(240) + 54.1837. This LSS and LSS13 performed similarly well in an independent external validation.

Conclusions:
MLR-based estimates of AUCLSS provide DARs that deviate minimally from the reference. LSSs allow the reduction of patient discomfort, a ∼50% reduction of TDM-related workload for nursing staff and blood loss and a ∼25% reduction in laboratory workload. These benefits may encourage wider use of busulfan TDM, supporting safe and efficacious personalized dosing.
Long-term risk of de novo mental health conditions after hysterectomy with ovarian conservation: a cohort study
Authors: Laughlin-Tommaso Shannon K. , Satish Anisha , Khan Zaraq , Smith Carin Y. , Rocca Walter A. , Stewart Elizabeth A. 
Published: September 2019

Abstract

Objective:
The aim of this research was to study the long-term risk of de novo mental health conditions in women who underwent hysterectomy with bilateral ovarian conservation compared with age-matched referent women.

Methods:
Using the Rochester Epidemiology Project records-linkage system, we identified a historical cohort of 2,094 women who underwent hysterectomy with ovarian conservation for benign indications at age ≥18 years and with an index date between 1980 and 2002 in Olmsted County, Minnesota. Each woman was age-matched (±1 y) to a referent woman residing in the same county who had not undergone hysterectomy or any oophorectomy before the index date. These two cohorts were followed historically to identify de novo mental health conditions. We estimated hazard ratios (HRs) and 95% confidence intervals (95% CIs) using Cox proportional hazards models adjusted for 20 preexisting chronic conditions and other potential confounders. We also calculated absolute risk increases (ARIs) and reductions (ARRs) at 30 years of follow-up.

Results:
Over a median follow-up of 21.9 years, women who underwent hysterectomy at any age experienced increased risks of de novo depression (adjusted HR 1.26; 95% CI, 1.12-1.41; ARI 6.6%) and anxiety (adjusted HR 1.22; 95% CI, 1.08-1.38; ARI 4.7%). The association for depression increased significantly with younger age at hysterectomy, but did not vary significantly by indication. Interactions were not significant for anxiety.

Conclusions:
Hysterectomy, even with ovarian conservation, is associated with an increased long-term risk of de novo depression and anxiety, especially when performed in women who are younger.

Video Summary:

http://links.lww.com/MENO/A465.
The Incremental Hospitalization Cost of Significant Transport-Related Traumatic Brain Injury
Authors: Van Deynse Helena , Van Belleghem Griet , Hubloue Ives , Lauwaert Door , Moens Maarten , Pien Karen , Devos Stefanie , Putman Koen 
Published: September 2019

Aim:
This study aims to determine the incremental cost of acute hospitalization for traumatic brain injury (TBI) compared with matched controls. A second purpose is to identify the factors contributing to this hospital costs.

Methodology:
Analyses were performed on administrative data for injured patients, hospitalized in Belgium between 2009 and 2011 following a road traffic accident. Cases were matched to a control with similar injuries but without TBI. The incremental hospitalization cost of TBI and the factors contributing to the hospital costs were determined using multivariable regression modeling with gamma distribution and log link.

Results:
A descriptive comparison of cases and controls shows clear differences in healthcare utilization and costs. The presence of a TBI increases the cost by a factor between 1.66 (95% confidence interval: 1.52-1.82) and 2.08 (95% confidence interval: 1.72-2.51). Regarding healthcare utilization, the most important determinants of hospital costs are surgical complexity, use of magnetic resonance imaging, intensive care unit admission, and mechanical ventilation.

Discussion:
To our knowledge, this is the first matched-control study calculating the incremental hospitalization cost of TBI. The insights provided by this study are relevant in the context of prospective payments and can be an incentive for investments in prevention policies and extramural care.