bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA expression profiling of BMSCs in osteonecrosis of the femoral head associated with increased adipogenic and decreased osteogenic differentiation
Authors: Wang Qingyu , Yang Qiwei , Chen Gaoyang , Du Zhenwu , Ren Ming , Wang Ao , Zhao Haiyue , Li Zhaoyan , Zhang Guizhen , Song Yang 
Published: June 2018

AbstractLong noncoding RNAs (lncRNAs) are critical gene expression regulators and are involved in several bone diseases. To explore the potential roles of lncRNAs in osteonecrosis of the femoral head (ONFH), we investigated for the first time the lncRNA expression profile of bone marrow mesenchymal stem cells (BMSCs) from patients with steroid-induced ONFH (SONFH) with microarray and bioinformatics analysis. A total of 1878 lncRNAs and 838 mRNAs were significantly up-regulated while 1842 lncRNAs and 1937 mRNAs were statistically down-regulated in the SONFH group compared with control group. The results validated by qRT-PCR were consistent with the microarray profiling data, especially involved in upregulation and downregulation of critical lncRNAs as well as mRNAs expression related to adipogenic and osteogenic differentiation. Pathway analyses revealed 40 signaling pathways with significant differences, especially the signaling pathways to regulate stem cell pluripotency. The CNC and ceRNA network indicated that lncRNA RP1-193H18.2, MALAT1 and HOTAIR were associated with abnormal osteogenic and adipogenic differentiation of BMSCs in the patients with SONFH. Our results suggest the lncRNA expression profiles were closely associated with the abnormal adipogenic and osteogenic transdifferentiation of BMSCs during the development of SONFH and explore a new insight into the molecular mechanisms of SONFH.
Phase diagrams and multistep condensations of spin-1 bosonic gases in optical lattices
Authors: Zan Xiaolei , Liu Jing , Han Jinsen , Wu Jianhua , Li Yongqiang 
Published: June 2018

AbstractMotivated by recent experimental processes, we systemically investigate strongly correlated spin-1 ultracold bosons trapped in a three-dimensional optical lattice in the presence of an external magnetic field. Based on a recently developed bosonic dynamical mean-field theory (BDMFT), we map out complete phase diagrams of the system for both antiferromagnetic and ferromagnetic interactions, where various phases are found as a result of the interplay of spin-dependent interaction and quadratic Zeeman energy. For antiferromagnetic interactions, the system demonstrates competing magnetic orders, including nematic, spin-singlet and ferromagnetic insulating phase, depending on longitudinal magnetization, whereas, for ferromagnetic case, a ferromagnetic-to-nematic-insulating phase transition is observed for small quadratic Zeeman energy, and the insulating phase demonstrates the nematic order for large Zeeman energy. Interestingly, at low magnetic field and finite temperature, we find an abnormal multi-step condensation of the strongly correlated superfluid, i.e. the critical condensing temperature of the m
F
= −1 component with antiferromagnetic interactions demonstrates an increase with longitudinal magnetization, while, for ferromagnetic case, the Zeeman component m
F
= 0 demonstrates a local minimum for the critical condensing temperature, in contrast to weakly interacting cases.
A novel species of the marine cyanobacterium Acaryochloris with a unique pigment content and lifestyle
Authors: Partensky Frédéric , Six Christophe , Ratin Morgane , Garczarek Laurence , Vaulot Daniel , Probert Ian , Calteau Alexandra , Gourvil Priscillia , Marie Dominique , Grébert Théophile , Bouchier Christiane , Le Panse Sophie , Gachenot Martin , Rodríguez Francisco , Garrido José L. 
Published: June 2018

AbstractAll characterized members of the ubiquitous genus Acaryochloris share the unique property of containing large amounts of chlorophyll (Chl) d, a pigment exhibiting a red absorption maximum strongly shifted towards infrared compared to Chl a. Chl d is the major pigment in these organisms and is notably bound to antenna proteins structurally similar to those of Prochloron, Prochlorothrix and Prochlorococcus, the only three cyanobacteria known so far to contain mono- or divinyl-Chl a and b as major pigments and to lack phycobilisomes. Here, we describe RCC1774, a strain isolated from the foreshore near Roscoff (France). It is phylogenetically related to members of the Acaryochloris genus but completely lacks Chl d. Instead, it possesses monovinyl-Chl a and b at a b/a molar ratio of 0.16, similar to that in Prochloron and Prochlorothrix. It differs from the latter by the presence of phycocyanin and a vestigial allophycocyanin energetically coupled to photosystems. Genome sequencing confirmed the presence of phycobiliprotein and Chl b synthesis genes. Based on its phylogeny, ultrastructural characteristics and unique pigment suite, we describe RCC1774 as a novel species that we name Acaryochloris thomasi. Its very unusual pigment content compared to other Acaryochloris spp. is likely related to its specific lifestyle.
Design of a compact quad‐band antenna with independent frequency tuning
Authors: Islam Sk.N. , Kumar M. , Sen G. , Das S. 
Published: June 2018

A compact, planar, low profile microstrip line‐fed quad‐band antenna is presented with operating frequencies at 2.5/3.6/5.5/7.5 GHz. The antenna consists of a rectangular split‐ring resonator (SRR), a stepped impedance resonator (SIR) inside the ring, a slot on the SIR and a pair of SRRs either side of the matching network. Each of the resonators generates its own individual band which is independently tunable. The antenna is compact in size having dimensions 0.10λ0 × 0.13λ0. The radiation patterns are omnidirectional and bilateral in the H‐plane and the E‐plane, respectively, at all the resonance frequencies. The simulated results are observed and reported in terms of S‐parameters, gain and radiation patterns. A prototype structure is fabricated and the measured results are compared with those obtained from the simulation.
Impact of planetesimal eccentricities and material strength on the appearance of eccentric debris disks
Authors: Kim M. , Wolf S. , Löhne T. , Kirchschlager F. , Krivov A. V. 
Published: June 2018

Context. Since circumstellar dust in debris disks is short-lived, dust-replenishing requires the presence of a reservoir of planetesimals. These planetesimals in the parent belt of debris disks orbit their host star and continuously supply the disk with fine dust through their mutual collisions.
Aims. We aim to understand effects of different collisional parameters on the observational appearance of eccentric debris disks. These parameters are the eccentricity of the planetesimal belt, dynamical excitation, and the material strength.
Methods. The collisional evolution of selected debris disk configurations was simulated with the numerical code ACE. Subsequently, selected observable quantities are simulated with our newly developed code DMS. The impact of the eccentricity, dynamical excitation, and the material strength is discussed with respect to the grain size distribution, the spectral energy distribution, and spatially resolved images of debris disk systems.
Results. The most recognizable features in different collisional evolutions are as follows. First, both the increase of dynamical excitation in the eccentric belt of the debris disk system and the decrease of the material strength of dust particles result in a higher production rate of smaller particles. This reduces the surface brightness differences between the periastron and the apastron sides of the disks. For very low material strengths, the “pericenter glow” phenomenon is reduced and eventually even replaced by the opposite effect, the “apocenter glow”. In contrast, higher material strengths and lower dynamical excitation of the system result in an enhancement of asymmetries in the surface brightness distribution. Second, it is possible to constrain the level of collisional activity from the appearance of the disk, for example, the wavelength-dependent apocenter-to-pericenter flux ratio. Within the considered parameter space, the impact of the material strength on the appearance of the disk is stronger than that of dynamical excitation of the system. Finally, we find that the impact of the collisional parameters on the net spectral energy distribution is weak.
Neuropsychotherapie in der Rehabilitation erworbener Hirnschädigungen
Authors: Pischel Cornelia 
Published: June 2018

ZusammenfassungDie hohe Komorbidität psychischer Störungen bei neurologischen Patienten hat nicht nur Auswirkung auf den neurorehabilitativen Behandlungserfolg, auf das
sozialmedizinische Outcome und die Lebensqualität der Patienten, sondern auch auf die Länge des Krankenhausaufenthalts, auf Komplikationen und Kostenaspekte.
Der Artikel ist ein Plädoyer für den frühen Beginn von Interventionen, für interdisziplinäre Zusammenarbeit und Aufklärung.
Die integrierte Behandlung funktioneller neurologischer Lähmungen
Authors: Schmidt Roger , Piliavska Kateryna , Trier Charlotte , Dettmers Christian 
Published: June 2018

ZusammenfassungFunktionelle Neurologische Symptome (FNS) stellen in der Neurologie und Neurorehabilitation eine wiederkehrende Aufgabe dar. Sie bleiben ohne stimmige
neurologische Erklärung und werfen die Frage nach einer psychischen Erkrankung auf. Das klinische Vorgehen umfasst gezielte neurologische,
funktionstherapeutische und psychotherapeutische Maßnahmen. Trägt das gesamte Behandlungsteam diesen Therapieplan konsequent mit, erweisen sich FNS als
grundsätzlich gut behandelbare Gesundheitsstörungen.
Der orientierungsgestörte Patient mit Beaufsichtigungspflicht in der Neuroreha
Authors: Weiß Irene , Pohl Marcus 
Published: June 2018

ZusammenfassungIn der folgenden Arbeit werden die Orientierungsstörung und ihre Erscheinungsformen im Kontext der neurologisch-neurochirurgischen Frührehabilitation beschrieben. Die Relevanz der Orientierungsstörungen wird dargestellt und sie werden von anderen Störungsbildern abgegrenzt. Außerdem werden neben möglichen Konzepten und Maßnahmen zur Behandlung von Störungen der Orientierung auch die juristischen Grundlagen beschrieben und erläutert.
A novel technique using high energy synchronous double-wave laser in endoscopic submucosal dissection of patients with superficial esophageal neoplasm
Authors: Yao Jun , Li Jun , Wang Peng , Liu Feng , Li Zhaoshen 
Published: June 2018

Abstract
Background Endoscopic submucosal dissection (ESD) has been widely used to treat superficial esophageal neoplasms (SENs). Intraoperative bleeding is one of the main concerns that makes ESD in the esophagus more difficult and time consuming with higher complication rates. We introduced a novel laser endoknife system that enabled better intraoperative hemostasis, and preliminarily investigated its feasibility in ESD for patients with SENs.
Methods 17 consecutive patients with SENs were prospectively enrolled. The laser endoknife system was used in marking and submucosal dissection. Data on therapeutic outcomes were collected and analyzed.
Results The median diameter of the lesions was 2.5 cm and of the resected specimens was 3.0 cm. The median procedure time was 48 minutes. Histologic evaluation revealed 15 high grade intraepithelial neoplasias and two squamous cell carcinomas. No intraoperative bleeding occurred during laser cutting and no significant complications occurred postoperatively. Curative R0 resection was achieved in all patients.
Conclusions Our new laser endoknife system was feasible in the submucosal dissection of SENs and showed great prospects for future application.
Correlation Between the Responses to Growth Hormone (GH) Treatment During Childhood and Adulthood in a Monocentric Cohort of GH-Deficient Patients
Authors: Thilmany Sarah , Mchirgui Leila , Brunelle Chloé , Beauloye Véronique , Maiter Dominique , Alexopoulou Orsalia 
Published: June 2018

AbstractOur aim was to analyze a cohort of patients with childhood-onset growth hormone deficiency (GHD) to evaluate if there is some correlation between the response to GH treatment during childhood and adulthood, respectively. This was an observational retrospective monocentric cohort study of 47 patients treated with GH during childhood and adulthood. Changes in growth parameters during childhood were compared with the increase of IGF-I z-score and other indexes of GH response (body composition, lipid profile) after 1 year of treatment in adulthood. The only significant positive correlation was observed between final growth velocity during the last year of childhood GH treatment and increase in IGF-I z-score in GH-treated adults (r=0.592, p=< 0.01). No correlation was observed between growth-promoting effects of GH as child and metabolic changes induced by GH as adult. We also observed a negative correlation between weight at the end of childhood GH treatment and the IGF-I response during first year of treatment in adults (r=− 0.335, p <0.05). No significant positive correlation could be observed between the main parameters that evaluate response to GH treatment in children and adults. However, the final growth velocity, which may be considered as one of the main criteria of end of GH treatment in children, was identified as parameter that could predict future response to GH treatment in adulthood.
Short-Term and Long-Term Effects of Bisphenol A (BPA) Exposure During Breastfeeding on the Biochemical and Endocrine Profiles in Rats
Authors: Santos-Silva Ana , de Moura Egberto , Pinheiro Cintia , Oliveira Elaine , Lisboa Patricia 
Published: June 2018

AbstractNeonates can be exposed to bisphenol A (BPA) through placenta and milk, and BPA is associated with disorders such as precocious puberty and obesity. We evaluated the effects of BPA exposure during breastfeeding on the biochemical and endocrine profiles in young and adult rat progeny. From postnatal day (PND) 3 to 15 dams were divided into low-dose BPA treatment [50 μg/kg/day s.c. (BPA-LD)], high-dose BPA treatment [5 mg/kg/day s.c. (BPA-HD)], and Control (vehicle) groups. Milk was collected at PND15 and 21, which represents the end of exposure and 6 days after withdrawal, respectively. Dams were euthanized at weaning. Offspring of both genders were euthanized at PND15, 21, and 180. Milk estradiol levels were lower in the BPA-HD group than in the control group at PND 15; however, they were higher at PND21. Female rats whose mothers were BPA-exposed showed more significant differences from those in the control group, including better glycemic control and lipid profiles and higher food intake without higher adiposity, in adulthood than in the weaning period, when they presented with higher adiposity and hyperestrogenism. Conversely, male rats showed more abnormalities after BPA exposure compared to control rats, including insulin, leptin, testosterone, and thyroid hormone changes, when young but exhibited fewer alterations in adulthood, with increase only in LDLc in the BPA-HD rats. Taken together, the present findings suggest that exposure to BPA exclusively through milk affects adiposity, metabolism, and/or hormones of offspring in the short and long term, possibly compromising normal development in both sexes.
Über den Einfluß der antithrombotischen Behandlung auf die Narbenbildung nach experimentellem Myokardinfarkt
Authors: Benda L , Zischka W 
Published: June 2018

ZusammenfassungAuf Grund histologischer Untersuchungen an Hunden, bei denen durch Unterbindung des linken apikalen Astes des Ramus descendens der linken Koronararterie eine Myomalazie erzeugt worden war, konnte beim Vergleich mit unbehandelten Tieren unter der Behandlung mit Venostasin keine nachteilige Wirkung im Sinne einer Hemmung der Narbenbildung beobachtet werden. Auch wenn Venostasin überdosiert wurde, verlief die Narbenbildung ungestört.
A Description of Clot Retraction as a Visual Experience
Authors: Ballerini Giorgio , Seegers Walter H 
Published: June 2018

SummaryClot retraction is reviewed as a visual experience from the elementary considerations to more complicated and uncertain perspectives. The extent of retraction is dependent upon temperature, cell volume, surface contact, pH, fibrinogen concentration, thrombin concentration, calcium ion concentration, and platelet concentration. Platelets function in their own unique way. This quality is lost by such treatment as dialysis, ultrasonic waves, storage, and freezing. In the latter case there is some protection in glycerol solutions. Plasma contains dialyzable material concerned with clot retraction. This includes glucose and phosphorous, and perhaps other substances. Moreover, plasma contains one or more proteins of interest in clot retraction, and this protein(s) can be adsorbed on barium carbonate and eluted with sodium citrate solution. There may be clot retraction without the dialyzable material of plasma if the nondialyzable protein(s) are present and vice versa. The work is illustrated extensively with photographs and variables are considered in terms of three dimensional projection. In addition the ideas reviewed were developed in terms of information obtained with time lapse motion picture photography.
Etude clinique ”in vivo” de la Résistance du Clou hémostatique chez l’Homme
Authors: Lewalle J , Bounameaux Y , Roskam J 
Published: June 2018

Résumé et ConclusionsAprès avoir systématiquement étudié le temps de saignement moyen au niveau des avant-bras chez l’homme normal et dans divers états pathologiques, les auteurs ont éprouvé la résistance des clous hémostatiques ayant mis fin aux hémorragies en exerçant au niveau du bras une contre-pression standardisée.Furent considérés comme anormalement fragiles les clous correspondant à des reprises des saignements, comme résistants les clous s’opposant à de telles reprises.Des observations ainsi effectuées, il résulte notamment que 1º) les clous hémostatiques des thrombopéniques sont résistants, et peut-être même davantage que ceux des sujets normaux; 2º) chez des patients traités, surtout énergiquement, par des anticoagulants indirects ou souffrant d’une coagulopathie, on observe de façon générale une diminution de la résistance des clous hémostatiques.
Prothrombin as Co-Factor of the Circulating Anticoagulant in Systemic Lupus Erythematosus?
Authors: Loeliger A , Alsbach E. J. J ,   with the technical assistance of Miss
Published: June 2018

SummaryA 35-year old man with lupus erythematosus of the skin is demonstrated, who also shows signs of systemic L. E.: sometimes slightly increased ESR, varying thrombocytopenia, slightly prolonged coagulation and prothrombin time, positive cepnalin-cholesterol flocculation test, biologically false positive syphilis reactions and signs of a slightly increased haemolysis. Electrophoretic examination of the serum proteins presents practically normal values, certainly no hypergammaglobulinaemia. Analytical examination of coagulation reveals hypoprothrombinaemia and an anticoagulant most probably directed against thrombocyte factor 3, intrinsic thromboplastin and tissue thromboplastin. The anticoagulant seems to be only active in the presence of prothrombin. Prothrombin therefore, is considered a co-factor of the anticoagulant. The inactive anticoagulant is localized in the gamma globulins. The possible cause of the hypoprothrombinaemia (immune reaction?) and the data in the literature are discussed.
Urokinase Excretion in Health and its Alteration in Certain Disease States
Authors: Smyrniotis Fotios E , Fletcher Anthony P , Alkjaersig Norma , Sherry Sol 
Published: June 2018

Summary1. Urokinase excretion rates in normal subjects were found to be independent of age, sex and urine volume.2. Urokinase excretion rates were found to be raised following the onset of myocardial infarction (p < 0.001) and after an attack of coronary insufficiency (p = 0.02). Excretion rates were depressed in patients suffering from carcinomatosis (p < 0.001), congestive cardiac failure (0.05 < p < 0.1) and uremia (p < 0.001).3. These differences suggest that significant alterations in the plasma fibrinolytic system may result as a consequence of disease states.
Arthroscopic Dorsal Capsuloplasty in Scapholunate Tears EWAS 3: Preliminary Results after a Minimum Follow-up of 1 Year
Authors: Coulomb Rémy , Kouyoumdjian Pascal , Mares Olivier , Degeorge Benjamin 
Published: June 2018

Purpose We retrospectively evaluated the results of all arthroscopic dorsal scapholunate (SL) capsuloplasty without pinning in patients presenting predynamic instability and dorsal capsuloscapholunate septum lesions on arthro–computed tomography scan after failed medical treatment.
Materials and Methods Fifteen patients, mean age 34.3 years, underwent all arthroscopically assisted dorsal capsuloplasty. Patients were assessed preoperatively and postoperatively by a clinical (pain, Watson's test, range of motion, and strength), functional (quick disabilities of the arm, shoulder, and hand), patient-rated wrist evaluation, and Mayo wrist score scores), and radiological (SL gap and dorsal intercalated segmental instability [DISI]) examination. SL tears were evaluated during surgery by European Wrist Arthroscopy Society (EWAS) classification.
Results The mean follow-up period was 20.2 months (range, 12–41). Preoperatively, positive Watson's test was noted in all cases. DISI deformity was noted in three cases without any SL gap. The SL instability was graded EWAS IIIB (n = 8) or EWAS IIIC (n = 7). Postoperatively, positive Watson's test was noted in only one case. Activity pain decreased from 7.8 preoperatively to 2.4 postoperatively. Range of motion in flexion–extension increased from 92.9 degrees preoperatively to 126.2 degrees postoperatively. Grip strength increased from 24.2 preoperatively to 38.2 postoperatively. At final follow-up, range of motion in flexion–extension and grip strength were estimated at 87 and 91% compared with contralateral side, respectively. All functional scores were significantly improved at the last follow-up. No radiographic SL gapping in grip views or DISI deformity was noted.
Discussion Cadaveric studies demonstrated that the dorsal portion of SL ligament is critical for the stability of the SL complex. The entire arthroscopic SL capsuloplasty technique provides reliable results for pain relief, avoiding postoperative stiffness associated with open procedures. It is an alternative technique for patients with predynamic SL instability after failure of medical management and shall not prelude the resort to any further open procedure.
Level of Evidence This is a level IV, case series.
Percutaneous Management of Enterocutaneous Fistulae and Abscess–Fistula Complexes
Authors: Erickson Abigail , Ahuja Chaitanya , Vea Romulo , Sangster Guillermo , D'Agostino Horacio , Ballard David 
Published: June 2018

AbstractAbscess–fistula complexes and enterocutaneous fistulae are due to postoperative, spontaneous, and inflammatory etiologies. Conservative, percutaneous, endoscopic, and surgical treatment options are available options. Interventional radiologists have an array of different treatment strategies, often starting with percutaneous drainage of associated intra-abdominal abscesses. This review article details different percutaneous management strategies, focusing on percutaneous catheter strategies for abscess-fistula complexes along with tract closures strategies for enterocutaneous fistulae.