bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macro-qualitative Comparisons: Grounded Theory and the Comparative Case of Norwegian and Danish Food Industries since the 1990s Transformations
Authors: Klimek Bjørn 
Published: July 2019

Abstract
This article examines macro-qualitative methodology specified for studies in comparative economic sociology. It elaborates a qualitative approach to comparative theory development. An examination of the socio-philosophical roots of social science theory is given, grounded theory methodology is reconstructed and research designs for macro-qualitative studies are discussed. It is argued that grounded theory methodology is able to contribute to macro-comparative studies as knowledge accumulation in case-specific research projects enables researchers to develop empirically grounded and plural notions of comparative theory. The research design presented for macro-qualitative inquiry builds on a middle-range attempt to accumulate knowledge in a micro-meso-macro procedure, including the productive examination of empirically grounded theoretical concepts at each analytical level. A previous macro-qualitative case study on Norwegian and Danish food industries since the 1990s turn is reconstructed to demonstrate how qualitative sociology is able to contribute to research frontiers that usually are dominated by quantitative economics.
A Functional Approach to Garshunography
Authors: Kiraz George A. 
Published: July 2019

Abstract
It is argued here that functionalism lies at the heart of garshunographic writing systems (where one language is written in a script that is sociolinguistically associated with another language). Giving historical accounts of such systems that began as early as the eighth century, it will be demonstrated that garshunographic systems grew organically because of necessity and that they offered a certain degree of simplicity rather than complexity. While the paper discusses mostly Syriac-based systems, its arguments can probably be expanded to other garshunographic systems.
Some Remarks on the Use of Garšūnī and Other Allographic Writing Systems by the Melkites
Authors: Pahlitzsch Johannes 
Published: July 2019

Abstract
The aim of this paper is to address the question to what extent and for what reasons the Melkites, especially of Southern Syria and Egypt, resorted to allographic writing systems, of which garšūnī, the writing of Arabic with Syriac letters, was only one mode. Indeed, various languages such as Greek, Arabic, Syriac and Christian Palestinian Aramaic (CPA) coexisted in the Melkite community, which is characterized by its linguistic diversity. Melkite garšūnī texts can be dated to between the 11th and the late 13th centuries. While the Melkites were not the first to use garšūnī, this mode of writing was in this period far more widespread among them than in the other oriental Christian communities and not limited to notes and colophons, also including liturgical texts and probably a poem on the Mamluk conquest of Tripoli. Other allographic writing systems were also used by the Melkites, such as writing Arabic in Greek characters, Greek in CPA script or Greek in Syriac script. Consequently a rich, very versatile corpus of allographic writing modes was employed by the Melkites between the 9th and 13th centuries for different kinds of texts. Thus the idea that the use of a specific allographic mode can be attributed to the desire to express a sense of group identity or to the reverence for a specific sacred language seems not generally applicable for the Melkites. At different times and places various Melkite groups had different preferences, because there was no single Melkite prestige language. Therefore it is necessary to establish for each case the respective reasons for the application of a certain allographic writing system.
Attending to the Chemical Senses
Authors: Spence Charles 
Published: July 2019

Abstract
Theorizing around the topic of attention and its role in human information processing largely emerged out of research on the so-called spatial senses: vision, audition, and to a lesser extent, touch. Thus far, the chemical senses have received far less research interest (or should that be attention) from those experimental psychologists and cognitive neuroscientists interested in the topic. Nevertheless, this review highlights the key role that attentional selection also plays in chemosensory information processing and awareness. Indeed, many of the same theoretical approaches/experimental paradigms that were originally developed in the context of the spatial senses, can be (and in some cases already have been) extended to provide a useful framework for thinking about the perception of taste/flavour. Furthermore, a number of those creative individuals interested in modifying the perception of taste/flavour by manipulating product-extrinsic cues (such as, for example, music in the case of sonic seasoning) are increasingly looking to attentional accounts in order to help explain the empirical phenomena that they are starting to uncover. However, separate from its role in explaining sonic seasoning, gaining a better understanding of the role of attentional distraction in modulating our eating/drinking behaviours really ought to be a topic of growing societal concern. This is because distracted diners (e.g., those who eat while watching TV, fiddling with a mobile device or smartphone, or even while driving) consume significantly more than those who mindfully pay attention to the sensations associated with eating and drinking.
The Linear Sensitivity of the North Atlantic Oscillation and Eddy-Driven Jet to SSTs
Authors: Baker Hugh S. , Woollings Tim , Forest Chris E. , Allen Myles R. 
Published: July 2019

Abstract
The North Atlantic Oscillation (NAO) and eddy-driven jet contain a forced component arising from sea surface temperature (SST) variations. Due to large amounts of internal variability, it is not trivial to determine where and to what extent SSTs force the NAO and jet. A linear statistical–dynamic method is employed with a large climate ensemble to compute the sensitivities of the winter and summer NAO and jet speed and latitude to the SSTs. Key regions of sensitivity are identified in the Indian and Pacific basins, and the North Atlantic tripole. Using the sensitivity maps and a long observational SST dataset, skillful reconstructions of the NAO and jet time series are made. The ability to skillfully forecast both the winter and summer NAO using only SST anomalies is also demonstrated. The linear approach used here allows precise attribution of model forecast signals to SSTs in particular regions. Skill comes from the Atlantic and Pacific basins on short lead times, while the Indian Ocean SSTs may contribute to the longer-term NAO trend. However, despite the region of high sensitivity in the Indian Ocean, SSTs here do not provide significant skill on interannual time scales, which highlights the limitations of the imposed SST approach. Given the impact of the NAO and jet on Northern Hemisphere weather and climate, these results provide useful information that could be used for improved attribution and forecasting.
Simulating Future Runoff in a Complex Terrain Alpine Catchment with EURO-CORDEX Data
Authors: Smiatek Gerhard , Kunstmann Harald 
Published: July 2019

AbstractWith large elevation gradients and high hydrometeorological variability, Alpine catchments pose special challenges to hydrological climate change impact assessment. Data from seven regional climate models run within the Coordinated Regional Climate Downscaling Experiments (CORDEX), each driven with a different boundary forcing, are used to exemplarily evaluate the reproduction of observed flow duration curves and access the future discharge of the Ammer River located in Alpine southern Germany applying the hydrological simulation model called the Water Flow and Balance Simulation Model (WaSiM). The results show that WaSiM reasonably reproduces the observed runoff for the entire catchment when driven with observed precipitation. When applied with CORDEX evaluation data (1989–2008) forced by ERA-Interim, the simulations underestimate the extreme runoff and reproduce the high percentile values with errors in the range from −37% to 55% with an ensemble mean of around 15%. Runs with historical data 1975–2005 reveal larger errors, up to 120%, with an ensemble mean of around 50% overestimation. Also, the results show a large spread between the simulations, primarily resulting from deficiencies in the precipitation data. Results indicate future changes for 2071–2100 in the 99.5th percentile runoff value of up to 9% compared to 1975–2005. An increase in high flows is also supported by flow return periods obtained from a larger sample of highest flows over 50 years, which reveals for 2051–2100 lower return periods for high runoff values compared to 1956–2005. Obtained results are associated with substantial uncertainties leading to the conclusion that CORDEX data at 0.11° resolution are likely inadequate for driving hydrologic analyses in mesoscale catchments that require a high standard of fidelity for hydrologic simulation performance.
The Ocean Mesoscale Regime of the Reduced-Gravity Quasigeostrophic Model
Authors: Samelson R. M. , Chelton D. B. , Schlax M. G. 
Published: July 2019

AbstractA statistical-equilibrium, geostrophic-turbulence regime of the stochastically forced, one-layer, reduced-gravity, quasigeostrophic model is identified in which the numerical solutions are representative of global mean, midlatitude, open-ocean mesoscale variability. Solutions are forced near the internal deformation wavenumber and damped linearly and by high-wavenumber enstrophy dissipation. The results partially rationalize a recent semiempirical stochastic field model of mesoscale variability motivated by a global eddy identification and tracking analysis of two decades of satellite altimeter sea surface height (SSH) observations. Comparisons of model results with observed SSH variance, autocorrelation, eddy, and spectral statistics place constraints on the model parameters. A nominal best fit is obtained for a dimensional SSH stochastic-forcing variance production rate of 1/4 cm2 day−1, an SSH damping rate of 1/62 week−1, and a stochastic forcing autocorrelation time scale near or greater than 1 week. This ocean mesoscale regime is nonlinear and appears to fall near the stochastic limit, at which wave-mean interaction is just strong enough to begin to reduce the local mesoscale variance production, but is still weak relative to the overall nonlinearity. Comparison of linearly inverted wavenumber–frequency spectra shows that a strong effect of nonlinearity, the removal of energy from the resonant linear wave field, is resolved by the gridded altimeter SSH data. These inversions further suggest a possible signature in the merged altimeter SSH dataset of signal propagation characteristics from the objective analysis procedure.
Orthotopic continent urinary reservoir (Indiana Pouch) in children after cystectomy for bladder exstrophy
Authors: Caione P. , De Gennaro M. , Capozza N. , Nappo S. 
Published: July 2019

In cases of failed exstrophic closure, total cystectomy is sometimes performed combined with external urinary diversion or ureterosigmoidostomy. Prolonged life expectation and the request for a high quality of life, characteristic of pediatric and juvenile age, make it mandatory to look for different surgical solutions. Among 44 patients (26 males and 18 females) born with “exstrophy-epispadias complex”, the creation of a new orthotopic urinary reservoir, according to the “Indiana Pouch” technique, was chosen in 2 children, 4 and 9 years of age respectively, who had previously undergone a total cystectomy elsewhere. The reservoir is made of a ceco-colic segment 35 cm long detubularized on one tenia and remodelled. Ureters are reimplanted with an antireflux technique on the second tenia. Continence is assured by the ileo-cecal valve opportunely reinforced. Both patients are now perfectly continent day and night and voiding is assured by transurethral intermittent catheterization.
Antiemetic effect of oral maropitant treatment before the administration of brimonidine ophthalmic solution in healthy cats
Authors: Kanda Teppei , Toda Chisato , Morimoto Haruka , Shimizu Yuki , Itoi Takamasa , Furumoto Kayo , Okamura Yasuhiko , Iwata Eri 
Published: July 2019

Objectives The aim of this study was to investigate the antiemetic, behavioural and physiological effects of oral maropitant treatment before the administration of brimonidine ophthalmic solution in healthy cats. Methods Five cats received oral maropitant 8 mg or no treatment (control) 18 h before the administration of one drop of brimonidine solution in both eyes. Each cat was administered each of the two treatments, with a washout period of 1 week. The incidence of emesis, retching, sialorrhoea and lip-licking after brimonidine administration was recorded, while behavioural and physiological parameters, including heart rate, mean blood pressure, respiratory frequency and rectal temperature, were recorded before and 0, 30, 60, 90, 120, 180 and 240 mins after brimonidine administration. Results Emesis and retching were not observed when maropitant was administered. However, 4/5 cats exhibited vomiting and retching in the absence of maropitant pretreatment. The incidence of emesis and retching after brimonidine administration was significantly lower in the treatment group than in the control group. Sialorrhoea occurred in one cat in the control group, while all cats showed lip-licking after brimonidine administration. There were no significant differences in the incidence of sialorrhoea and lip-licking between the two groups. Although behaviour scores were comparable between the two groups, those obtained during heart rate, mean blood pressure and respiratory frequency measurements were significantly lower than the baseline scores; this indicated a sedative effect after brimonidine administration. The heart rate and mean blood pressure significantly decreased after brimonidine administration in both groups, while there were no intergroup differences in the heart rate, mean blood pressure, respiratory frequency and rectal temperature. Conclusions and relevance Oral maropitant treatment before the administration of brimonidine ophthalmic solution in cats can alleviate emesis and retching without affecting the sedative effects of brimonidine and important physiological parameters.
A Review and Clinical Perspective of the Impact of Osteoporosis on the Spine
Authors: Carlson Bayard C. , Robinson William A. , Wanderman Nathan R. , Sebastian Arjun S. , Nassr Ahmad , Freedman Brett A. , Anderson Paul A. 
Published: July 2019

Introduction: Osteopenia and osteoporosis are common conditions in the United States. The health consequences of low bone density can be dire, from poor surgical outcomes to increased mortality rates following a fracture. Significance: This article highlights the impact low bone density has on spine health in terms of vertebral fragility fractures and its adverse effects on elective spine surgery. It also reviews the clinical importance of bone health assessment and optimization. Results: Vertebral fractures are the most common fragility fractures with significant consequences related to patient morbidity and mortality. Additionally, a vertebral fracture is the best predictor of a subsequent fracture. These fractures constitute sentinel events in osteoporosis that require further evaluation and treatment of the patient’s underlying bone disease. In addition to fractures, osteopenia and osteoporosis have deleterious effects on elective spine surgery from screw pullout to fusion rates. Adequate evaluation and treatment of a patient’s underlying bone disease in these situations have been shown to improve patient outcomes. Conclusion: With an increased understanding of the prevalence of low bone mass and its consequences as well an understanding of how to identify these patients and appropriately intervene, spine surgeons can effectively decrease the rates of adverse health outcomes related to low bone mass.
Analyzing Upward Deviation of Actual vs Predicted Drug Sales in Japan for a Reasonable Drug-Pricing Policy
Authors: Shibata Shoyo , Fukumoto Daigo , Suzuki Takeshi , Ozaki Koken 
Published: July 2019

Background:Predictions of drug sales play an important role in setting drug prices in Japan, where drug prices are highly regulated. One of 2 primary Japanese drug-pricing methodologies—the cost calculation method— refers extensively to the prediction of drug sales in establishing drug prices. Deviations from predicted sales can induce disproportionate drug prices and unexpected pharmaceutical expenditures. This study aimed to estimate the upward deviation of actual sales from predicted sales and to explore the predictors of such upward deviation.Methods:Estimates of upward deviation in 2015 were produced for new molecular entities (NMEs) approved in 2006-2015. To identify the predictors associated with upward deviation through binary logistic regression analyses, sales within 3 years of launch and in the predicted year in which peak sales would be reached were used.Results:Estimated upward deviation was more than 1220 billion yen in 2015 for the targeted drugs. Drugs priced by the cost calculation method or by obtaining additional indications were significantly more likely to show an upward deviation from predicted peak sales.Conclusion:There is substantial upward deviation between actual and predicted drug sales in Japan. So long as drug sales predictions are used in drug price calculations, a flexible repricing system is needed to buffer unexpected pharmaceutical expenditures.
TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging
Authors: Davizon-Castillo Pavel , McMahon Brandon , Aguila Sonia , Bark David , Ashworth Katrina , Allawzi Ayed , Campbell Robert A. , Montenont Emilie , Nemkov Travis , D’Alessandro Angelo , Clendenen Nathan , Shih Lauren , Sanders Natalie A. , Higa Kelly , Cox Allaura , Padilla-Romo Zavelia , Hernandez Giovanni , Wartchow Eric , Trahan George D. , Nozik-Grayck Eva , Jones Kenneth , Pietras Eric M. , DeGregori James , Rondina Matthew T. , Di Paola Jorge 
Published: July 2019

AbstractAging and chronic inflammation are independent risk factors for the development of atherothrombosis and cardiovascular disease. We hypothesized that aging-associated inflammation promotes the development of platelet hyperreactivity and increases thrombotic risk during aging. Functional platelet studies in aged-frail adults and old mice demonstrated that their platelets are hyperreactive and form larger thrombi. We identified tumor necrosis factor α (TNF-α) as the key aging-associated proinflammatory cytokine responsible for platelet hyperreactivity. We further showed that platelet hyperreactivity is neutralized by abrogating signaling through TNF-α receptors in vivo in a mouse model of aging. Analysis of the bone marrow compartments showed significant platelet-biased hematopoiesis in old mice reflected by increased megakaryocyte-committed progenitor cells, megakaryocyte ploidy status, and thrombocytosis. Single-cell RNA-sequencing analysis of native mouse megakaryocytes showed significant reprogramming of inflammatory, metabolic, and mitochondrial gene pathways in old mice that appeared to play a significant role in determining platelet hyperreactivity. Platelets from old mice (where TNF-α was endogenously increased) and from young mice exposed to exogenous TNF-α exhibited significant mitochondrial changes characterized by elevated mitochondrial mass and increased oxygen consumption during activation. These mitochondrial changes were mitigated upon TNF-α blockade. Similar increases in platelet mitochondrial mass were seen in platelets from patients with myeloproliferative neoplasms, where TNF-α levels are also increased. Furthermore, metabolomics studies of platelets from young and old mice demonstrated age-dependent metabolic profiles that may differentially poise platelets for activation. Altogether, we present previously unrecognized evidence that TNF-α critically regulates megakaryocytes resident in the bone marrow niche and aging-associated platelet hyperreactivity and thrombosis.
Preparation and properties of a coniferin enantiomer
Authors: Maeda Haruka , Tsuyama Taku , Takabe Keiji , Kamitakahara Hiroshi , Takano Toshiyuki 
Published: July 2019

Abstract

l-Coniferin (1L), which is an enantiomer of natural coniferin (d-coniferin (1D)), was prepared from l-glucose according to the conventional method for compound 1D. The reactivity of l-glucose and its derivatives was found to be almost same as that of the corresponding d-glucose and its derivatives during the preparation for compound 1L. Compound 1L showed resistance toward enzymatic hydrolysis by commercial β-glucosidase from Almond. However, unlike compound 1D, compound 1L was not transported across the membrane obtained from differentiating xylem of a hybrid poplar in the present assay. The result suggested for the first time that the d-/l-configuration of the glucose moiety of coniferin is an important factor affecting coniferin transport across the membrane.
Performance and working mechanism of tension–compression composite anchorage system for earthen heritage sites
Authors: Wang Donghua , Cui Kai , Wu Guopeng , Feng Fei , Yu Xiangpeng 
Published: July 2019

Abstract
Although the fully grouted tension anchorage system (T-anchorage system) has been widely used in the field of anchoring of earthen heritage sites, it has always suffered from the failure of the bolt–slurry interface debonding and the strong attenuation of the shear stress of the bolt–slurry interface along the embedment length. In this article, a new type of fully grouted tension–compression composite anchorage system (TC-anchorage system) is proposed, which is made up of a pressure bearing system with the same diameter of the anchor hole at the end of the tension bolt. The in situ anchorage, pull-out test and interfacial stress–strain monitoring were carried out for the T-anchorage systems and the TC-anchorage systems. This was based on the preliminary analysis and comparison of the structure and working mechanism of the two anchorage systems. The test results show that: the average ultimate load of the TC-anchorage system is about 40% higher than that of the T-anchorage system. TC-anchorage systems have the characteristics of small elastic deformation and large plastic deformation. The strain at the bolt–slurry interface varies progressively along the embedded length with the increase of load in a positive skewness–bimodal–negative skewness curve. The working mechanism of TC-anchorage systems includes three progressive stages: bolt–slurry interface debonding, conical slurry formation and slurry extrusion. The research conclusion provides a reference for the application of TC-anchorage systems in the protection and reinforcement of earthen heritage sites.