bluuebunny/crossref_metadata_2025_split huggingface dataset:
Most elderly patients hospitalized for heart failure lack the abilities needed to perform the tasks required for self‐care: impact on outcomes
Authors: Vidán María T. , Martín Sánchez Francisco‐Javier , Sánchez Elísabet , Ortiz Francisco‐Javier , Serra‐Rexach José A. , Martínez‐Sellés Manuel , Bueno Héctor 
Published: August 2019

AbstractAimTo evaluate the abilities to perform essential tasks for heart failure (HF) self‐management in elderly patients, and its influence on post‐discharge prognosis.Methods and resultsOverall, 415 patients ≥70 years old hospitalized for HF were included and followed during 1 year. The ability to perform six specific tasks (use of a scale, weight registration, diuretic identification, knowledge of salted foods, oedema identification, and treatment adjustment) was tested and distributed on terciles (T) of performance. Correlation with the self‐administered questionnaire European HF Self‐care Behaviour Scale (EHFScBS) was evaluated. The independent influence of self‐care on 1‐year mortality and readmission risks was calculated by Cox proportional hazards regression analysis. Mean age was 80.1 years. On average, patients could perform 2.9 ± 1.6 of self‐care tasks, and only 5.3% could perform the six tasks correctly. Patients with previous HF self‐care education had slight better performance (3.2 ± 1.6 vs 2.8 ± 1.6, P < 0.02). A weak correlation was found between EHFScBS and number of tasks correctly performed (r = −0.135; P = 0.006). One‐year mortality in T1, T2, and T3 patients was 33.0%, 20.7%, and 14.1%, respectively (P = 0.002). Multivariable analysis showed T2 and T3 groups having a lower adjusted mortality risk compared with T1 [hazard ratio (HR) 0.58; 95% confidence interval (CI) 0.32–1.03; and HR 0.40; 95% CI 0.21–0.77, respectively], without differences in readmissions.ConclusionMost elderly patients admitted for HF are unable to perform several essential tasks needed for HF self‐care. Self‐perception of care was poorly correlated with real ability, and poor self‐care ability was associated with higher 1‐year mortality risk.
Mitochondrial functionality and metabolism in T cells from progressive multiple sclerosis patients
Authors: De Biasi Sara , Simone Anna Maria , Bianchini Elena , Lo Tartaro Domenico , Pecorini Simone , Nasi Milena , Patergnani Simone , Carnevale Gianluca , Gibellini Lara , Ferraro Diana , Vitetta Francesca , Pinton Paolo , Sola Patrizia , Cossarizza Andrea , Pinti Marcello 
Published: August 2019

AbstractPatients with primary progressive (PP) and secondary progressive (SP) forms of multiple sclerosis (MS) exhibit a sustained increase in the number of Th1, T cytotoxic type‐1 and Th17 cells in peripheral blood, suggesting that the progressive phase is characterized by a permanent peripheral immune activation. As T cell functionality and activation are strictly connected to their metabolic profile, we investigated the mitochondrial functionality and metabolic changes of T cell subpopulations in a cohort of progressive MS patients. T cells from progressive patients were characterized by low proliferation and increase of terminally differentiated/exhausted cells. T cells from PP patients showed lower Oxygen Consumption Rate and Extracellular Acidification Rate, lower mitochondrial mass, membrane potential and respiration than those of SP patients, a downregulation of transcription factors supporting respiration and higher tendency to shift towards glycolysis upon stimulation. Furthermore, PP effector memory T cells were characterized by higher Glucose transporter ‐1 levels and a higher expression of glycolytic‐supporting genes if compared to SP patients. Overall, our data suggest that profound differences exist in the phenotypic and metabolic features of T cells from PP and SP patients, even though the two clinical phenotypes are considered part of the same disease spectrum.
Recent advances and challenges in the recovery and purification of cellular exosomes
Authors: Ayala‐Mar Sergio , Donoso‐Quezada Javier , Gallo‐Villanueva Roberto C. , Perez‐Gonzalez Victor H. , González‐Valdez José 
Published: August 2019

AbstractExosomes are nanovesicles secreted by most cellular types that carry important biochemical compounds throughout the body with different purposes, playing a preponderant role in cellular communication. Because of their structure, physicochemical properties and stability, recent studies are focusing in their use as nanocarriers for different therapeutic compounds for the treatment of different diseases ranging from cancer to Parkinson's disease. However, current bioseparation protocols and methodologies are selected based on the final exosome application or intended use and present both advantages and disadvantages when compared among them. In this context, this review aims to present the most important technologies available for exosome isolation while discussing their advantages and disadvantages and the possibilities of being combined with other strategies. This is critical since the development of novel exosome‐based therapeutic strategies will be constrained to the effectiveness and yield of the selected downstream purification methodologies for which a thorough understanding of the available technological resources is needed.
Preparation of porous aromatic framework modified graphene oxide for pipette‐tip solid‐phase extraction of theophylline in tea
Authors: Deng Qilin , Sun Liping , Zhu Tao 
Published: August 2019

AbstractA new material called as porous aromatic frameworks modified graphene oxide (PAFs‐GO) was synthesized, and it was used as an adsorbent in pipette‐tip SPE for the effective purification and enrichment of theophylline in tea sample by HPLC. The properties of PAFs‐GO were characterized by field emission SEM, FTIR, thermogravimetry analysis and Brunauer Emmett Teller N2 adsorption‐desorption analysis. The results of static adsorption and dynamic adsorption test showed PAFs‐GO had higher adsorption ability (93.25 mg/g) than graphene oxide. The LOD and LOQ of the method were 0.0141 and 0.0471 µg/mL, respectively. The acceptable method reproducibility was found as intra‐ and inter‐day precisions, yielding the RSDs <4.62%. By introducing PAFs as support skeleton, the specific surface area of GO was effectively increased, and the penetrability was improved. Studies showed that the proposed method had been successfully applied for purification and enrichment of theophylline in complex tea matrix.
Heat propagation in thermally conductive polymers of PA6 and hexagonal boron nitride
Authors: Fischer Andreas J. , Zhong Yuhua , Zhang Luchong , Wu Wei , Drummer Dietmar 
Published: August 2019

SummaryThermally conductive polymers offer new possibilities for the heat dissipation in electric and electronic components, for example, by a three‐dimensional shaping of the heat sinks. To face safety regulations, improved fire performance of those components is required. In contrast to unfilled polymers, those materials exhibit an entirely different thermal behavior. To investigate the flammability, a phosphorus flame retardant was incorporated into thermally conductive composites of polyamide 6 and hexagonal boron nitride. The flame retardant decreased the thermal conductivity only slightly. However, the burning behavior changed significantly, due to a different heat propagation, which was investigated using a thermographic camera. An optimum content of hexagonal boron nitride for a sufficient thermal conductivity and fire performance was found between 20 and 30 vol%. The improvement of the fire performance was due to a faster heat release out of the pyrolysis zone and an earlier decomposition of the flame retardant. For higher contents of hexagonal boron nitride, the heat was spread faster within the part, promoting an earlier ignition and increasing the decomposition rate of the flame retardant.
Meat quality, fatty acids, volatile compounds, and antioxidant properties of lambs fed pasture versus mixed diet
Authors: Luo Yulong , Wang Bohui , Liu Chang , Su Rina , Hou Yanru , Yao Duo , Zhao Lihua , Su Lin , Jin Ye 
Published: August 2019

AbstractThe aim of the present work was to investigate the effects of feeding regimens (pasture vs. mixed diet) on meat quality, fatty acids, volatile compounds, and antioxidant properties in lamb meat. In total, 24 lambs were allotted into two feeding regimens at 10.23 kg live weight. Lambs were fed on pasture grass (PG group, n = 12) or mixed diet (M group, n = 12). Longissimus thoracis (LT) muscle samples from the M group had a higher intramuscular fat (IMF) (p < 0.05), pH45minvalue (p < 0.01), and ash (p < 0.05) than the PG group. In contrast, the shear force (p < 0.05), L*(p < 0.05), and b* (p < 0.001) in M group were lower than in PG group. Analyses indicated that PG group contained higher linolenic acid (C18:3n3) and docosatrienoic acid (C22:3n6) (p < 0.05) than the M group. Major volatile compounds in the muscles included hexanal, heptanal, nonanal, octanal, 1‐pentanol, 1‐hexanol, 1‐octen‐3‐ol, and 2,3‐octanedione. The levels of hexanal, nonanal, and 2,3‐octanedione were significantly lower in PG lamb muscle (p < 0.01). In contrast, 1‐pentanol and 1‐hexanol levels were higher in M lamb muscle (p < 0.01). Muscle from PG lamb exhibited higher catalase (CAT) and glutathione peroxidase (GPx) activity (p < 0.05). PG muscle also contained a higher radical‐scavenging ability (RSA; p < 0.001) and cupric‐reducing antioxidant capacity (CUPRAC; p < 0.05). Overall, the improved antioxidant status in PG muscle inhibited lipid peroxidation (aldehydes and ketones), thereby improving the meat quality.
Neural activity during working memory encoding, maintenance, and retrieval: A network‐based model and meta‐analysis
Authors: Kim Hongkeun 
Published: August 2019

AbstractIt remains unclear whether and to what extent working memory (WM) temporal subprocesses (i.e., encoding, maintenance, and retrieval) involve shared or distinct intrinsic networks. To address this issue, I constructed a model of intrinsic network contributions to different WM phases and then evaluated the validity of the model by performing a quantitative meta‐analysis of relevant functional neuroimaging data. The model suggests that the transition from the encoding to maintenance and to retrieval stages involves progressively decreasing involvement of the dorsal attention network (DAN), but progressively increasing involvement of the frontoparietal control network (FPCN). Separate meta‐analysis of each phase effect and direct comparisons between them yielded results that were largely consistent with the model. This evidence included between‐phase double dissociations that were consistent with the model, such as encoding > maintenance contrast showing some DAN, but no FPCN, regions, and maintenance > encoding contrast showing the reverse, that is, some FPCN, but no DAN, regions. Two closely juxtaposed regions that are members of the DAN and FPCN, such as inferior frontal junction versus caudal prefrontal cortex and superior versus inferior intraparietal sulcus, showed a high degree of functional differentiation. Although all regions identified in the present study were already identified in previous WM studies, this study uniquely enhances our understating of their roles by clarifying their network membership and specific associations with different WM phases.
Informal workplace learning: Development and validation of a measure
Authors: Decius Julian , Schaper Niclas , Seifert Andreas 
Published: August 2019

AbstractInformal workplace learning (IWL) is an important part of work‐related continuing education, especially in the case of blue‐collar workers. The current article presents a new measure of IWL, which we developed based on the already existing Dynamic Model of Informal Learning by Tannenbaum et al. (2010). We extended the model to eight components by theoretical considerations, introducing a second‐order structure. Each component is represented on the IWL scale with three items, the subscales have sound internal consistencies (α range between .76 and .92). The article also presents a short version of the scale comprising eight items (α = .79). Study 1 describes the process of item selection, while Study 2 deals with different theoretically conceivable models comparing their model fits. The predicted model with eight factors in a second‐order structure achieves the best model fit. In addition, convergent, discriminant, and criterion validity are demonstrated. Medium‐sized relationships of IWL components to conscientiousness and learning outcomes confirm the nomological network we developed previously in our study. The discussion provides limitations and possible scientific and practical applications of the IWL scale, for example, the transfer of the measure to other contexts and target groups.
Secondary immune thrombocytopenic purpura with renal cell carcinoma
Authors: Nakazawa Shigeaki , Kawamura Masataka , Nakano Kosuke , Ueda Norichika , Kishikawa Hidefumi , Kashiwagi Hirokazu , Uemura Motohide , Imamura Ryoichi , Nishimura Kenji , Nonomura Norio 
Published: August 2019

IntroductionSeveral types of cancers are reported to induce secondary immune thrombocytopenia resembling immune thrombocytopenic purpura‐like syndrome. However, renal cell carcinoma‐induced immune thrombocytopenic purpura is an extremely rare phenomenon.Case presentationA 73‐year‐old male with right renal tumor and multiple enlarged lymph nodes presented severe thrombocytopenia, without bone or hepatic metastasis. Although platelet transfusion and high‐dose immunoglobulin treatment were refractory, surgical resection of the tumor and lymph nodes promptly improved thrombocytopenia. After recurrence, he presented thrombocytopenia again. Tyrosine kinase inhibitor treatment was ceased due to uncontrollable hemorrhagic gastric ulcer. The patient eventually died of cancer 4 months after surgery. Flow cytometry analysis revealed the presence of integrin glycoprotein IIb/IIIa, which is a fibronectin/fibrinogen receptor on platelets and as an antigen in immune thrombocytopenic purpura.ConclusionTo the best of our knowledge, this is the first reported case of renal cell carcinoma‐induced immune thrombocytopenic purpura that demonstrates the presence of platelet‐autoantibody glycoprotein IIb/IIIa.
The two sides of Islamophobia and the perception of threat from Islamic terrorists
Authors: Tartaglia Stefano , Rollero Chiara , Bergagna Elisa 
Published: August 2019

AbstractThere is a heightened interest concerning the understanding of prejudice toward Muslims in Europe, steadily increasing since 2001. This study aimed at investigating whether the phenomenon of Islamophobia could have two different manifestations (i.e., Islamoprejudice and Secular Critique of Islam). In particular, we assessed whether two social attitudes, Right‐Wing Authoritarianism (RWA, i.e., authoritarian aggression, and conservatism) and Social Dominance Orientation (SDO), could predict differently the two dimensions. Moreover, we wanted to investigate the different influence of the two dimensions in relation to the perceived threat from terrorism. A sample of 366 Italian adults participated in the study completing a self‐report questionnaire. Data were analyzed by means of a structural equation model. Results showed that RWA and SDO were differently related to Islamoprejudice and Secular Critique of Islam, suggesting that certain forms of critique of Islam should not be associated with individual prejudice, because motivated only by secular, democratic, and universalistic convictions, denoting the traces of cultural biases. However, the nonprejudicial and apparently less problematic dimension of Islamophobia, that is, Secular Critique, does not preserve people from perceiving the threat from terrorism, in the same way as Islamoprejudice. Implications are discussed.
Assessment of tumor volume and density as a measure of the response of advanced hepatocellular carcinoma to sorafenib: Application of automated measurements on computed tomography scans
Authors: Yamamichi Junta , Kawaguchi Yasunori , Otsuka Taiga , Nakashita Shunya , Mizobe Hideaki , Eguchi Yuichiro , Kimura Shinya 
Published: August 2019

Background and AimTo better predict patient survival, we used automated tumor volume and density measurements to make an objective radiological assessment of the response of advanced hepatocellular carcinoma (HCC) to treatment with sorafenib.MethodsPatients treated with sorafenib were identified retrospectively. Those who were diagnosed with Child‐Pugh class A liver function, Barcelona‐Clinic Liver Cancer stage C, and Eastern Cooperative Oncology Group performance status grade 0/1 were enrolled (n = 22). Reviews of contrast‐enhanced computed tomography images were supported by the automated measurement of lesions using computer software. Treatment responses were assessed using volume and density criteria. Kaplan–Meier methods and multivariate Cox regression analysis were used to evaluate treatment responses and identify the most significant prognostic factors for overall survival (OS).ResultsAfter patients were dichotomized according to volume and density criteria, the median OS for those with an objective response (OR) (complete response + partial response) was 20.4 months and that for those with a non‐OR (stable disease + progressive disease) was 9.3 months (P = 0.009). The best multivariate regression model for survival identified volume and density criteria (OR or non‐OR) as a significant variable, along with baseline alpha‐fetoprotein levels (log‐rank test, P = 0.01). No other conventional criteria were identified as significant.ConclusionsTumor volume and density assessment using automated lesion measurements may be an objective method of evaluating responses of advanced HCC to treatment with sorafenib.
Molecular toxicity of nanoplastics involving in oxidative stress and desoxyribonucleic acid damage
Authors: Zheng Tongtong , Yuan Dong , Liu Chunguang 
Published: August 2019

AbstractMicroplastic pollution attracted extensive attention because of its global presence and adverse effects on ecosystem. However, it is insufficient to clear the effects of nanoplastics on organisms at the molecular level. Herein, a nanopolystyrene (50 nm) was used to examine molecular responses of superoxide dismutase (SOD) and desoxyribonucleic acid (DNA) using spectroscopy (UV‐vis, circular dichroism spectra, and fluorescence measurements) and single cell gel electrophoresis methods. Results showed that nanopolystyrene induced oxidative stress, involving in the increase of SOD activity and malondialdehide (MDA) content, and DNA damage because of the significant increase of olive tail moment, head optical density, and tail DNA percentage in the groups at exposure concentrations above 5 × 10−6 mol/L. The second structural and microenvironment of aromatic amino acids of SOD were changed with nanopolystyrene exposure. The fluorescence of SOD was quenched by nanopolystyrene at exposure concentration above 1 × 10−5 mol/L, and the quenching mode could be ascribed to the static type. The results and the combined methods are favorable to explore the molecular toxicity of other nanoplastics and the interaction mechanism.
Screening high‐risk populations for esophageal and gastric cancer
Authors: Li Selena , Chung Daniel C. , Mullen John T. 
Published: August 2019

AbstractCancers of the esophagus and stomach remain important causes of mortality worldwide, in large part because they are most often diagnosed at advanced stages. Thus, it is imperative that we identify and treat these cancers in earlier stages. Due to significant heterogeneity in incidence and risk factors for these cancers, it has been challenging to develop standardized screening recommendations. This review summarizes the current recommendations for screening populations at high risk of developing esophagogastric cancers.
Resource availability affects temporal variation of phytoplankton size structure in the Kuroshio east of Taiwan
Authors: Lin Fan‐Sian , Ho Pei‐Chi , Sastri Akash R. , Chen Chung‐Chi , Gong Gwo‐Ching , Jan Sen , Hsieh Chih‐hao 
Published: August 2019

AbstractThe on‐going discussion concerning how environmental factors determine phytoplankton size structure has centered around two hypotheses: (H1) The resource‐size relationship predicts that normalized biovolume size spectrum (NBSS) slopes for phytoplankton are progressively shallower with increasing resource availability and (H2) The temperature‐size relationship predicts that phytoplankton NBSS slopes steepen with increasing water temperature. To test these hypotheses, we examined 72 phytoplankton assemblage collections in the Kuroshio east of Taiwan. Total phytoplankton biomass was used as a proxy for resource availability instead of nutrients because nutrients are depleted and do not represent resource availability for oligotrophic seas. We found no significant relationship between NBSS slopes with temperature, providing little support for the temperature‐size rule. In contrast, a positive relationship between NBSS slopes and total biomass for most of the year lends general support to the resource‐size relationship, except during the winter and early spring. To explain this exception, we hypothesize that resource pulses occurring during the cold seasons are used more efficiently by small cells and promote faster growth of small relative to large phytoplankton because these pulses take place after a long period of resource depletion in oligotrophic seas; thus, the NBSS slopes become much steeper than would be expected from a positive resource‐size relationship. This deviation can be considered as nonsteady state in terms of phytoplankton size structure relative to resources. Nevertheless, we cannot rule out the possibility that grazing effects also play an important role in controlling phytoplankton size structure.
The mechanism by which social media influencers persuade consumers: The role of consumers’ desire to mimic
Authors: Ki Chung‐Wha ‘Chloe’ , Kim Youn‐Kyung 
Published: August 2019

AbstractWe explore the mechanism through which social media influencers (SMIs) persuade consumers to adopt brands. Guided by the influence framework, we propose and test empirically SMIs’ influence mechanism, which occurs in four principal stages: (a) a SMI's influence attempts (showcasing H1: attractive; H2: prestigious; H3 and H4: expert; H5: informative; and H6: interactive Instagram contents); (b) target consumers’ attitudinal response to the influence exercised (evaluating the SMI as a H7: taste and H8: opinion leader); which, in turn, affects (c) the targets’ desire to comply (the desire to mimic); and ultimately (d) their favorable behavioral outcomes (H9: social media word‐of‐mouth and H10: purchase intentions). On the basis of the survey data from 395 respondents, we used structural equation modeling to test our hypotheses and proposed model. We verified the robustness of our results using an ordered probit regression model and analyzed the mediating role of consumers’ desire to mimic SMIs in the influence mechanism. Our results confirm that the five aspects of influencing posts affect consumers’ attitudes positively and significantly, which in turn leads to positive behavioral outcomes through their desire to mimic SMIs. We discuss the results’ important implications for both scholars and practitioners.