bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abscisic acid enhances SmAPK1‐mediated phosphorylation of SmbZIP4 to positively regulate tanshinone biosynthesis in Salvia miltiorrhiza
Authors: Zhu Ruiyan , Peng Lulu , Xu Ying , Liu Changle , Shao Lili , Liu Tingyao , Shou Minyu , Lin Qinzhe , Wang Biao , Shi Min , Kai Guoyin 
Published: November 2024

Summary
Tanshinones, isolated from Salvia miltiorrhiza, is efficient to treat cardiovascular and cerebrovascular diseases. Abscisic acid (ABA) treatment is found to promote tanshinone biosynthesis; however, the underlying mechanism has not been fully elucidated.
A protein kinase namely SmAPK1 was identified as an important positive regulator of ABA‐induced tanshinone accumulation in S. miltiorrhiza. Using SmAPK1 as bait, a basic region leucine zipper (bZIP) family transcription factor SmbZIP4 was screened from the cDNA library. Functional identification reveals that SmbZIP4 negatively regulates tanshinone biosynthesis in hairy roots and transgenic plants through directly targeting SmGGPPS and SmCYP76AK1.
SmAPK1 phosphorylates the Ser97 and Thr99 site of SmbZIP4, leading to its degradation via the 26S proteasome pathway, which is promoted by ABA‐induced enhancement of SmAPK1 kinase activity. Degradation of SmbZIP4 upregulates the expression levels of SmGGPPS and SmCYP76AK1, resulting in increased tanshinone content.
Taken together, our results reveal new molecular mechanism by which SmAPK1‐SmbZIP4 module plays a crucial role in ABA‐induced tanshinone accumulation. This study sheds new insights in the biosynthesis of bioactive compounds in medicinal plants.
Effect of Tea Waste Extract Volume on Synthesis of TiO2 for Photodegradation of 2,4-dichlorophenol
Authors: Adnan Nadiatul Asma , Jaafar Nur Farhana , Tri Wahyuni Endang , Abdul Mutalib Auni Afifah , Mahmuelee Torlaema Tasnim Aisya 
Published: November 2024

The volume effect of tea waste extract was studied in synthesis of titanium dioxide (TiO2) namely TiO2-1 (1 mL), TiO2-3 (3 mL) and TiO2-5 (5 mL). The catalysts were characterized by XRD, FTIR, BET, UV-Vis DRS and FESEM. The role of tea waste extract in formation of TiO2 was tested to degrade 2,4-dichlorophenol (2,4-DCP) under visible light irradiation. The best photocatalytic degradation of 2,4-DCP was achieved using TiO2-1 (85%) compared with TiO2-3 (80%), TiO2-5 (77%) and P25 (71%). Furthermore, the optimum volume of tea waste extract was 1 mL and the results show that increasing volume of tea extract increased the band gap and crystallite size, while the surface area was decreased. The role of tea waste extract as capping agent in synthesis of TiO2 contributed significantly to the good photocatalytic degradation of 2,4-DCP.
Assessing Psychological Explanations for Jesus’ Post-Resurrection Appearances: A Response to Stephen H. Smith
Authors: Loke Andrew Ter Ern , Meader Nick 
Published: November 2024

Abstract
In a recent article published in this journal, Stephen Smith acknowledges that bereavement hallucination is an unlikely explanation for Jesus’ post-resurrection appearances, and suggests supplementing it with theories concerning collective delusion, distorted memory, and cognitive dissonance. Our response contributes to the discussion by bringing our expertise in psychology and New Testament studies together to advance interdisciplinary study on this important topic. We show that Smith’s discussion confounds real-life cases and laboratory experiments on memory, and mass psychogenic illness with illusions. Moreover, Smith fails to consider a number of important differences between the case concerning Jesus’ post-resurrection appearances and cases of cognitive dissonance and other psychological theories, which indicate that these theories are not plausible explanations concerning Jesus’ post-resurrection appearances.
Technology, Modernity, and the Possibility of Historical Understanding
Authors: Ashcroft Caroline 
Published: November 2024

Abstract
This paper traces the meaning of technology in Arendt and Foucault’s work, their historical analyses of technology, and the way that their notions of technology’s role in modernity influence their historical methods. I argue that whilst the two political thinkers approach the idea of technology from different perspectives, there is also substantial overlap in the way that they conceive of technology – often critically – as a wide-ranging set of practices of power interlocked with particular modes of knowledge. This helps to properly situate some aspects of their work that converge, for instance their analyses of what Foucault calls ‘biopolitics’. But their different conceptions of the historical character of technology, and its relationship to modernity, also create divergence: their concepts of ‘technology’ suggest different ways of thinking through the nature of historical continuity and discontinuity and the degree of access that we have to meaningful histories.
SLE inflammatory musculoskeletal abnormalities, confirmed by MRI, show a specific profile with a worse health-related quality of life
Authors: Corzo Patricia , Agustí Claramunt Anna , Garcia-Duitama Ivan , Carrión-Barberá Irene , Marsico Salvatore , Duran Jordà Xavier , Monfort Faure Jordi , Salman-Monte Tarek-Carlos 
Published: November 2024

Objectives To determine if there is a clinicodemographic or serological profile associated with MRI-confirmed inflammatory musculoskeletal abnormalities in SLE patients. To investigate the relationship between these alterations and HRQoL. Methods patients with SLE from our previous study in whom a wrist and hand MRI with contrast was performed were included. Sociodemographic, clinical, therapeutic, serological data and PROs were collected and correlated with MRI findings. Results 83 patients were analysed. Erosions and synovitis were more common in older patients (55 ± 12.61 vs 45.06 ± 12.18 years, p .001, 52.78 ± 12.99 vs 44.95 ± 12.49 years, p .011). Synovitis was less frequent in patients with nephritis (6.7% vs 24.3%, p .031). Treatment received showed some associations: patients with bone edema received more methotrexate (25% vs 6.3%, p .033), those with erosions and peritendonitis received less mycophenolic acid (5.6% vs 22.9%, p .034; 0% vs 12.8%, p .026). Peritendonitis correlated with higher SLEDAI-2K (7 ± 2.45 vs 3.64 ± 3.34, p .018). Worse HAQ Patients with synovitis, tenosynovitis, peritendonitis and bone edema reported higher pain (6.03 ± 2.57 vs 4.26 ± 2.49, p .005; 6.56 ± 1.95 vs 4.76 ± 2.75, p .017; 8.80 ± 1.30 vs 4.95 ± 2.55, p .001; 6.47 ± 2.62 vs 4.83 ± 2.58, p .026, respectively). Patients with synovitis reported higher fatigue numerical values (2.32 ± 0.82 vs 1.91 ± 0.84, p .035), with tenosynovitis worse FSS-9 (61.50 ± 1.73 vs 45.70 ± 16.80, p .015), and with both synovitis and peritendonitis worse HAQ (1.14 ± 0.69 vs 0.75 ± 0.65, p .031; 1.69 ± 0.07 vs 0.90 ± 0.69, p .018). Conclusion SLE patients with confirmed musculoskeletal alterations on MRI were generally older, less likely to have lupus nephritis, and received different treatments. They reported a worse HRQoL in terms of pain, fatigue and functional disability.
Impact of Nutritional Status on Chemotherapy Related Digestive Toxicity in Women With Breast Cancer
Authors: Olfa Berriche , Salma Mohsen , Othman Rym Ben , Mansour Hajer Ben , Houyem Khiari , Henda Jamoussi , Amel Mezlini 
Published: November 2024

Introduction: Any alteration in nutritional status can compromise the progression of breast cancer, as well as the tolerance and efficacy of chemotherapy. The aims of our study were to assess the nutritional status of breast cancer patients treated with chemotherapy and to identify nutritional factors that may exacerbate chemo-induced digestive toxicity. Methods: This descriptive cross-sectional study was conducted within the medical oncology department of the National Institute of Salah Azaiez. A Mediterranean Diet Score (MDS) was used to evaluate the level of adherence to the Mediterranean Diet. Nutritional status was assessed using 2 methods; body composition evaluation utilising the TANITA BC 601 impedance metre and High authority of health (HAS) criteria of malnutrition. Digestive effects were assessed with World Health Organization (WHO) grades ranging from 0 to 4. High grades 3 and 4 signified toxic grades. Results: We enrolled 107 adult women diagnosed with breast cancer undergoing the same chemotherapy protocol. The participants had an average age of 52.56 ± 9.75 years and an average BMI of 29.85 ± 5.72 kg/m2 with 78.5% classified as overweight. Malnutrition was observed in 41% of patients, while sarcopenia was present in 12%. Chemotherapy-related adverse effects were predominantly constipation (80%), diarrhea (73%), nausea (70%) and vomiting (63.4%) with one-third experiencing high-grade toxicity. Strong adherence to Mediterranean Diet was observed in 48.6% of cases and higher MDS scores were inversely correlated with the severity of nausea ( P = .01) and constipation ( P = .02). Malnutrition was significantly associated with all digestive toxicities except with constipation. Sarcopenia was associated only with vomiting ( P = .005). Conclusion: There is a relationship between nutritional status and digestive toxicity, justifying early nutritional treatment to improve the tolerance and efficacy of chemotherapy.
Thoracic Endovascular Aortic Repair For The Management of Aorto-Esophageal Fistulae: A Systematic Review
Authors: Wang Changtian , Xi Zhilong , von Segesser Ludwig K. , Pozzoli Alberto , Ferrari Enrico 
Published: November 2024

Objective: Aorto-esophageal fistula (AEF) is a rare condition consisting in a fistula between the aorta and the esophagus. The thoracic endovascular aortic repair (TEVAR) has become an accepted treatment for initial AEF management, but large series are not available and outcomes are questionable. This study aims at evaluating the current evidence of TEVAR in AEF. Methods: A search on PubMed/MEDLINE and EMBASE was conducted up to June 2023. Data on article type, patients’ demographics, cause and type of AEF, clinical presentation, time from clinical presentation to TEVAR, strategies, mortality, and follow-up were analyzed. Results: 106 reports published between 1997 and 2023 were deemed eligible for this study (92 case reports; 14 case-series). A total of 163 patients (mean age: 58.9±16.5 years), diagnosed with AEF and treated with TEVAR (with or without staged surgical repair of the esophagus or the aorta) were included. A thoracic aortic aneurysm (34.4%) was the most common cause of AEF, followed by esophageal cancer (25.2%), foreign body in esophagus (13.5%) and post-TEVAR complication (9.8%). Primary AEF were 129 (79.1%), and secondary AEF were 34 (20.9%). TEVAR alone was performed 80 times (49.1%), while TEVAR with staged esophageal or aortic surgery 83 times (50.9%). The overall 30-day mortality was 11.7% (n=19): 18.8% in TEVAR alone and 4.8% in TEVAR with staged surgery, respectively (p=0.006). Mean follow-up time was 12.3±14.7 months. The overall 6-month mortality was 34.4% (n=56): 48.8% in TEVAR alone and 20.5% in TEVAR with staged surgery (p<0.001). Bleeding for recurrence of AEF and sepsis were the main causes of death. Conclusions: In case of AEF, TEVAR can be urgently performed for bleeding management and hemodynamic control. TEVAR alone is a valuable yet not definitive procedure. Instead, TEVAR followed by surgical repair may provide better outcomes and should be recommended, when possible. Clinical Impact This review summarizes the published papers on endovascular aortic repair for the treatment of aorto-esophageal fistulae. The clinicians can find several important details on how to manage the presence of an esophageal fistulae wich represents a potential life-threatening problem for the patients. The implantation of a thoracic endovascular aortic prosthesis represents a fast and reliable procedure in case of emergency but a second step surgical repair provides better outcomes and should be recommended in suitable patients.
The Super-Turbocharged End-to-Side Abductor Digiti Minimi and Anterior Interosseous Double Nerve Transfer Is Associated With Improved Ulnar Intrinsic Function
Authors: Chi David , Orr Jonah , Johnson Anna Rose , Llaneras Noah , Jacobson Lauren , Peters Blair R. , Patterson Megan M. , Mackinnon Susan E. 
Published: November 2024

Background: Nerve transfers to reinnervate ulnar intrinsic musculature can restore function in severe ulnar neuropathy, and supercharged end-to-side (SETS) nerve transfers have garnered early adoption. Given the relative expendability of the abductor digiti minimi (ADM), redirecting its axons to more critical components of the ulnar motor nerve (UMN) in a turbocharged end-to-side (TETS) nerve transfer with concomitant anterior interosseous SETS nerve transfer (AIN) as a super-turbocharged end-to-side (STETS) or twin-charged double nerve transfer may improve functional recovery. Methods: A retrospective study of patients undergoing the STETS AIN/ADM to UMN double nerve transfer or TETS ADM to UMN nerve transfer for severe ulnar neuropathy between 2020 and 2022 was performed. Primary outcomes were improvement in first dorsal interosseous (FDI) strength and Disabilities of the Arm, Shoulder, and Hand (DASH) scores. Dichotomous and continuous variables were compared with χ2 and t tests, respectively. Results: Fifty patients with severe ulnar nerve injuries were identified with at least 1-year surgical follow-up. Preoperative symptom duration was an average of 11.3 months. The STETS cohort (n = 42) reported significantly decreased DASH scores from 58 to 28 ( P < .001) and improved FDI Medical Research Council (MRC) score from 0.7 to 3.3 ( P < .001). The TETS cohort (n = 8) reported significantly decreased DASH scores from 54 to 23 ( P = .016) and improved FDI MRC score from 2.0 to 3.6 ( P = .008). Conclusions: Distal transfer of the ADM nerve to the ulnar deep motor branch in a turbocharged fashion is reported. The findings suggest that the STETS double nerve transfer may improve patient outcomes and warrants further investigation with prospective cohort studies.
Short-term effectiveness and safety of ustekinumab and vedolizumab in elderly and non-elderly patients with Crohn’s disease: a comparative study
Authors: Dar Lior , Shani Uria , Dotan Arad , Ukashi Offir , Ben-Horin Shomron , Kopylov Uri , Levartovsky Asaf 
Published: November 2024

Background: Inflammatory bowel disease (IBD) presents unique challenges in elderly patients due to comorbidities and treatment-related risks. Objectives: This study evaluates ustekinumab (UST) and vedolizumab (VDZ) efficacy and safety in elderly Crohn’s disease (CD) patients. Design: A retrospective cohort study at a tertiary medical center. Methods: CD patients aged ⩾60 years (elderly) treated with UST, compared to non-elderly (<60 years) patients treated with UST and elderly patients treated with VDZ. Clinical response was evaluated using the Harvey–Bradshaw index (HBI) and clinical biomarkers, alongside monitoring steroid use, hospitalization rates, treatment persistence, and surgical interventions. Results: The study included 166 CD patients: 32 elderly and 65 non-elderly patients treated with UST, and 69 elderly patients treated with VDZ. The mean duration of follow-up was 10.8 ± 2.8 months in the non-elderly group, 9.97 ± 3.28 months in the elderly UST group, and 10.0 ± 3.29 months in the VDZ group. Elderly UST patients were more likely to receive corticosteroids at initiation than non-elderly UST patients (44% vs 14%, p = 0.001). At 12 months, clinical response rates did not significantly differ between elderly and non-elderly UST groups, respectively (48% vs 40%, p = 0.5). However, elderly UST patients exhibited higher hospitalization rates over time compared to non-elderly UST patients (6-month: 19% vs 6.2%, p = 0.077; 12-month: 19% vs 4.6%, p = 0.055; log-rank p = 0.004). No significant differences were observed in clinical response and remission rates between elderly UST and elderly VDZ patients at 6 and 12 months. At 6 months, a higher hospitalization rate was observed in the UST group (19% vs 4.3% p = 0.027), but this difference did not persist over time. Conclusion: UST and VDZ are effective and safe treatments for elderly CD patients, despite higher hospitalization rates compared to non-elderly patients, likely due to age-related complications.
Trends in Ulnar Collateral Ligament Injuries and Surgery From 2010 to 2019: An Analysis of a National Medical Claims Database
Authors: Solomito Matthew J. , Kostyun Regina O. , Sabitsky Joshua T. , Nissen Carl W. 
Published: November 2024

Background: Ulnar collateral ligament (UCL) injuries have been on the rise for the past 3 decades. Current epidemiological studies on the incidence of UCL injuries have been limited to state or regional data. Purpose: To utilize a large national claims database to determine the rates of UCL injuries and UCL surgical procedures over the past decade (2010-2019) and whether there has been a change in UCL surgical procedure patterns in the United States. Study Design: Descriptive epidemiology study. Methods: The PearlDiver patient claims database was used to identify UCL injuries occurring from 2010 and 2019 that were sustained by male patients between 10 and 34 years of age. The study cohort was divided into 5 age groups (10-14, 15-19, 20-24, 25-29, and 30-34 years). Primary outcomes included the number of patients in each age group who sustained a UCL injury, the number of patients in each age group who underwent surgery, and the mean time from injury to surgery. Results: A total of 19,348 UCL injuries occurred between 2010 and 2019, and 13% required a surgical intervention. Most of the injuries (54%) occurred in the 15- to 19-year group. Patients in the 20- to 24-year group were more likely to undergo surgery versus the 15- to 19-year group. Results demonstrated a trend toward delayed surgical interventions in patients in the 20- to 24-year group in the latter part of the decade. Conclusion: Data suggested that male patients <20 years account for the majority of UCL injuries, while male patients aged between 20 and 24 years are most likely to undergo surgery. Despite a number of targeted injury-prevention strategies and rule changes in sports, the UCL injury rate remained high. Therefore, there is a clear and present need to continue to develop UCL injury-prevention strategies for the younger population.
FUT8 upregulates CD36 and its core fucosylation to accelerate pericyte-myofibroblast transition through the mitochondrial-dependent apoptosis pathway during AKI-CKD
Authors: Shang Yaxi , Wang Ziran , Yang Fan , Wang Weidong , Tang Qingzhu , Guo Xianan , Du Xiangning , Zhang Xu , Hao Jiaojiao , Lin Hongli 
Published: November 2024

Abstract
Background
Activation of pericytes leads to renal interstitial fibrosis, but the regulatory mechanism of pericytes in the progression from AKI to CKD remains poorly understood. CD36 activation plays a role in the progression of CKD. However, the significance of CD36 during AKI-CKD, especially in pericyte, remains to be fully defined.

Methods
GEO and DISCO database were used to analyze the expression of CD36 in pericyte during AKI-CKD; IRI to conduct AKI-CKD mouse model; Hypoxia/Reoxygenation (H/R) to induce the cell model; RT-qPCR and Western blotting to detect gene expression; IP and confocal-IF to determine the core fucosylation (CF) level of CD36. Flow cytometry (AV/PI staining) to detect the cell apoptosis and JC-1 staining to react to the change of mitochondrial membrane potential.

Results
During AKI to CKD progression, CD36 expression in pericytes is higher and may be influenced by CF. Moreover, we confirmed the positive association of CD36 expression with pericyte-myofibroblast transition and the progression of AKI-CKD in an IRI mouse model and hypoxia/reoxygenation (H/R) pericytes. Notably, we discovered that FUT8 upregulates both CD36 expression and its CF level, contributing to the activation of the mitochondrial-dependent apoptosis signaling pathway in pericytes, ultimately leading to the progression of AKI-CKD.

Conclusion
These results further identify FUT8 and CD36 as potential targets for the treatment in the progression of AKI-CKD.
Chromosome-level genome assemblies and genetic maps reveal heterochiasmy and macrosynteny in endangered Atlantic Acropora
Authors: Locatelli Nicolas S. , Kitchen Sheila A. , Stankiewicz Kathryn H. , Osborne C. Cornelia , Dellaert Zoe , Elder Holland , Kamel Bishoy , Koch Hanna R. , Fogarty Nicole D. , Baums Iliana B. 
Published: November 2024

Abstract
Background
Over their evolutionary history, corals have adapted to sea level rise and increasing ocean temperatures, however, it is unclear how quickly they may respond to rapid change. Genome structure and genetic diversity contained within may highlight their adaptive potential.

Results
We present chromosome-scale genome assemblies and linkage maps of the critically endangered Atlantic acroporids, Acropora palmata and A. cervicornis. Both assemblies and linkage maps were resolved into 14 chromosomes with their gene content and colinearity. Repeats and chromosome arrangements were largely preserved between the species. The family Acroporidae and the genus Acropora exhibited many phylogenetically significant gene family expansions. Macrosynteny decreased with phylogenetic distance. Nevertheless, scleractinians shared six of the 21 cnidarian ancestral linkage groups as well as numerous fission and fusion events compared to other distantly related cnidarians. Genetic linkage maps were constructed from one A. palmata family and 16 A. cervicornis families using a genotyping array. The consensus maps span 1,013.42 cM and 927.36 cM for A. palmata and A. cervicornis, respectively. Both species exhibited high genome-wide recombination rates (3.04 to 3.53 cM/Mb) and pronounced sex-based differences, known as heterochiasmy, with 2 to 2.5X higher recombination rates estimated in the female maps.

Conclusions
Together, the chromosome-scale assemblies and genetic maps we present here are the first detailed look at the genomic landscapes of the critically endangered Atlantic acroporids. These data sets revealed that adaptive capacity of Atlantic acroporids is not limited by their recombination rates. The sister species maintain macrosynteny with few genes with high sequence divergence that may act as reproductive barriers between them. In the Atlantic Acropora, hybridization between the two sister species yields an F1 hybrid with limited fertility despite the high levels of macrosynteny and gene colinearity of their genomes. Together, these resources now enable genome-wide association studies and discovery of quantitative trait loci, two tools that can aid in the conservation of these species.