bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periodontal treatment needs in the Medicaid patient population: a retrospective study in a US dental school
Authors: Sukalski Jennifer M. C. , McKernan Susan C. , Avila‐Ortiz Gustavo , Cunningham‐Ford Marsha A. , Qian Fang , Damiano Peter C. 
Published: December 2018

AbstractObjectivesThe aim of this study was to use electronic health records (EHRs) from a US dental school clinic to retrospectively investigate associations between periodontal treatment needs and insurance type in a newly insured adult Medicaid population. We hypothesized that newly insured Medicaid patients, covered by the Iowa Dental Wellness Plan (DWP), would display greater need for treatment than patients with other sources of financing.MethodsA retrospective chart review of EHRs of patients at the University of Iowa College of Dentistry and Dental Clinics (UI COD) from 2014 to 2016 was completed. The outcome of interest whether or not a new patient was indicated for scaling and root planing (SRP) based on clinical examination. Logistic regression models analyzed associations between treatment need and source of financing, adjusting for known periodontal disease risk indicators.ResultsA total of 1,259 patient charts were evaluated. SRP was indicated for 56 percent of all patients. Patients with DWP coverage had significantly greater unadjusted odds of being indicated for SRP than privately insured individuals (OR = 1.47, P = 0.009). However, this association did not remain significant after adjusting for known risk indicators.ConclusionsAlthough individuals enrolled in DWP were not significantly more likely to need treatment than individuals with other sources of financing when adjusting for risk indicators, their demonstrated clinical need was higher than privately insured adults. Public benefit programs could anticipate greater burden of periodontal need in low‐income populations due to increased prevalence of risk factors in this population.
Curcumin and a hemi-analogue with improved blood–brain barrier permeability protect against amyloid-beta toxicity in Caenorhabditis elegans via SKN-1/Nrf activation
Authors: Lee Elaine Hui-Chien , Lim Sherlyn Sheau-Chin , Yuen Kah-Hay , Lee Chong-Yew 
Published: December 2018

Abstract

Objectives
This study aims to investigate the blood–brain barrier (BBB) permeability of curcumin analogues with shortened linkers and their ability to protect against amyloid-beta toxicity in a whole organism model.

Method
Four curcumin analogues were synthesized. These analogues and curcumin were evaluated for their BBB permeability in the parallel artificial membrane permeability assay. The transgenic Caenorhabditis elegansGMC101 that expresses human Aβ1–42 was treated with the compounds to evaluate their ability to delay Aβ-induced paralysis. Expression of skn-1mRNA was examined on nematodes treated with selected efficacious compounds. In vitro Aβ aggregation in the presence of the compounds was performed.

Key findings
The four analogues showed improved BBB permeability vs curcumin in the PAMPA with the hemi-analogue C4 having the highest permeability coefficient. At 100 μm, analogues C1 and C4 as well as curcumin significantly prolonged the survival of the nematodes protecting against Aβ toxicity. However, only curcumin and C4 showed protection at lower concentrations. skn-1mRNA was significantly elevated in nematodes treated with curcumin and C4 indicating SKN-1/Nrf activation as a possible mode of action.

Conclusions
Analogue C4 provides a new lead for the development of a curcumin-based compound for protection against Aβ toxicity with an improved BBB permeability.
Clinical, histopathologic, cystoscopic, and fluorescence in situ hybridization analysis of proliferative urethritis in 22 dogs
Authors: Borys Moria A. , Hulsebosch Sean E. , Mohr F. Charles , Watson Katherine D. , Sykes Jane E. , Simpson Kenneth W. , Westropp Jodi L. 
Published: December 2018

BackgroundProliferative urethritis (PU) is a lower urinary tract disease of dogs characterized by frond‐like lesions in the urethra. The etiology of PU is unknown, although an association with bacterial cystitis is reported.ObjectivesDeep‐seated bacterial cystitis is associated with PU, particularly in dogs with neutrophilic or granulomatous inflammation.AnimalsTwenty‐two client‐owned dogs with PU and 5 control dogs euthanized for non‐urinary disease.MethodsIn retrospective analysis, medical records of dogs with PU from 1986 to 2016 were reviewed. Signalment, clinical signs, cystoscopic findings, antimicrobial use, and results of urine, bladder, or urethral tissue cultures, if available, were recorded. Histopathology was reviewed and classified as lymphocytic‐plasmacytic (LP), neutrophilic, LP‐neutrophilic (LPN), granulomatous, or pleocellular. Eubacterial fluorescence in situ hybridization (FISH) was performed on 18 tissue samples (13 cases, 5 controls), with subsequent evaluation of bacterial species.ResultsOf the 22 dogs, 9 had LP urethritis, 6 had LPN, 4 had pleocellular, and 3 had neutrophilic urethritis. Of note, 7 of 13 PU samples were FISH+ for adherent or invasive bacteria; 1 of 5 controls were FISH+ for adherent bacteria. Five dogs had negative urine and tissue cultures when FISH was positive. There was no association detected between the type of urethral inflammation and the results of urine and tissue culture or FISH.Conclusions and Clinical ImportanceThe type of inflammation varied widely in these 22 PU cases. Deep‐seated bacterial urethritis could be contributing to the inflammatory process in some dogs, regardless of the inflammation type. Urine and tissue cultures likely underestimate bacterial colonization of the urethra in dogs.
Some observations on models of growth and distribution with autonomous demand growth
Authors: Dutt Amitava Krishna 
Published: December 2018

AbstractThis paper offers some theoretical and methodological observations on a model of growth and distribution, recently developed by Franklin Serrano and others and called the Sraffian supermultiplier model, in which the growth of autonomous capitalist consumption demand and distribution are exogenously given and capacity utilization is at an exogenously given “normal” level in long‐run equilibrium. First, it provides a simple long‐run equilibrium version and dynamic formulation of the model, and compares it to other models of growth and distribution using a common framework and focusing on the effect of a change in income distribution on growth. Second, it shows that the model can be modified to examine other components of autonomous demand growth, including government spending, exports, consumption by workers, and investment and technical change, and to simultaneous multiple sources of autonomous demand growth. Finally, it comments on some methodological issues concerning the model, and on its implications for the notion of long‐run equilibrium.
The Queen's preferred chant and Greece's nineteenth century Orthodox‐Christian national problem
Authors: Ignatidou Artemis 
Published: December 2018

AbstractWhen in 1875 Queen Olga of Greece insisted a multi‐part chant be introduced in the Athens Cathedral, a widespread debate about the influence of Western European culture upon Greek‐Orthodox tradition was initiated in Athens. With a significant part of this debate originating in mid‐century Vienna, and Russian musical influences affecting the form of the otherwise ancient Byzantine chant, the issue of polyphony acquired cultural‐historical dimensions intimately connected to historical continuity and the Orthodox‐Christian musical tradition. The debate transformed rapidly from a musicological enquiry into a matter of national identity, and an otherwise innocent aesthetic choice showcased the musical dimensions of Greek national claims at continuity. This article examines the historical contingencies that fuelled this debate, showcases the importance of patronage for musical transference and highlights the potency of Greek national Orthodoxy as a carrier of historical continuity for the ethnic group, here seen through music.
Short‐term response to phenytoin sodium in Andersen‐Tawil syndrome‐1 with a cardiac‐dominant phenotype
Authors: Rai Maneesh K. , Pai Rohith , Prabhu Mukund A. , Pasha Syed Waleem , Kedambadi Rakshith C. , Kamath Padmanabh , Augustine Alfred J. , Bhavani Gangham SriLakshmi , Girisha Katta M. 
Published: December 2018

AbstractBackgroundAndersen‐Tawil syndrome (ATS) is a rare familial periodic paralysis that typically also affects the heart and skeletal system. Ventricular arrhythmias (VAs) are profound and difficult to control, but minimally symptomatic. In this report, we describe an atypical phenotype of ATS in two related families. We also report our experience with phenytoin sodium for the control of resistant VAs in these patients.Methods and ResultsBetween 2014 and 2018, seven siblings were diagnosed with ATS on the basis of cardiac arrhythmias and genetic evaluation. Heterozygous mutation with c.431G > C (p.G144A) in exon 2 of KCNJ2 gene was observed in all patients. Characteristic cardiac manifestations were noted in all patients but periodic paralysis or objective neurological involvement was distinctly absent. Phenytoin was considered for control of symptomatic VA in three patients. Intake of oral phenytoin (5 mg/kg/day) for 1 month completely suppressed VA (<1% in 24‐h Holter monitoring) in two patients, and significantly in the third (8% per 24 h) patient. Phenytoin was well‐tolerated in all three patients.ConclusionsWe describe a cardiac‐predominant phenotype in ATS. ATS should be suspected in patients with typical cardiac manifestations even in the absence of periodic paralysis. Our initial experience with short‐term use of phenytoin for control of resistant VAs is encouraging.
A new genomic tool for walnut (Juglans regia L.): development and validation of the high‐density Axiom™ J. regia 700K SNP genotyping array
Authors: Marrano Annarita , Martínez‐García Pedro J. , Bianco Luca , Sideli Gina M. , Di Pierro Erica A. , Leslie Charles A. , Stevens Kristian A. , Crepeau Marc W. , Troggio Michela , Langley Charles H. , Neale David B. 
Published: December 2018

SummaryOver the last 20 years, global production of Persian walnut (Juglans regia L.) has grown enormously, likely reflecting increased consumption due to its numerous benefits to human health. However, advances in genome‐wide association (GWA) studies and genomic selection (GS) for agronomically important traits in walnut remain limited due to the lack of powerful genomic tools. Here, we present the development and validation of a high‐density 700K single nucleotide polymorphism (SNP) array in Persian walnut. Over 609K high‐quality SNPs have been thoroughly selected from a set of 9.6 m genome‐wide variants, previously identified from the high‐depth re‐sequencing of 27 founders of the Walnut Improvement Program (WIP) of University of California, Davis. To validate the effectiveness of the array, we genotyped a collection of 1284 walnut trees, including 1167 progeny of 48 WIP families and 26 walnut cultivars. More than half of the SNPs (55.7%) fell in the highest quality class of ‘Poly High Resolution’ (PHR) polymorphisms, which were used to assess the WIP pedigree integrity. We identified 151 new parent‐offspring relationships, all confirmed with the Mendelian inheritance test. In addition, we explored the genetic variability among cultivars of different origin, revealing how the varieties from Europe and California were differentiated from Asian accessions. Both the reconstruction of the WIP pedigree and population structure analysis confirmed the effectiveness of the Applied Biosystems™ Axiom™ J. regia 700K SNP array, which initiates a novel genomic and advanced phase in walnut genetics and breeding.
Roles of the circadian clock and endocrine regulator in the photoperiodic response of the brown‐winged green bug Plautia stali
Authors: Tamai Takaaki , Shiga Sakiko , Goto Shin G. 
Published: December 2018

AbstractThe physiological mechanisms underlying photoperiodism in insects have been studied extensively, although the associated molecular machinery remains largely unknown. In the present study, we investigate the roles of the circadian clock gene cycle (cyc) and the endocrine regulator gene myoinhibitory peptide (Mip) in the photoperiodic response of the brown‐winged green bug Plautia stali Scott (Hemiptera, Pentatomidae). Typically, adult females of this species develop their ovaries under long‐day conditions, whereas they suppress its development under short‐day conditions. We find that RNA interference (RNAi) directed against cyc causes malfunction of the circadian clock governing the locomotor activity rhythm and yields abnormal activity profiles not only under constant darkness, but also under light/dark conditions. RNAi directed against cyc and Mip disrupts the photoperiodic response in ovarian development. cyc RNAi suppresses the ovarian development even under long‐day conditions, whereas Mip RNAi induces it even under short‐day conditions. We propose that the core circadian clock gene cyc regulates the photoperiodic response and that Mip is the causal regulator of juvenile hormone biosynthesis in the corpus allatum. Neither photoperiod, nor cyc RNAi affect Mip mRNA levels, and therefore it remains unknown how the photoperiodic information is processed and mediated by Mip.
The Jury Is Out: An Ethnographic Study of Lay Participation in the Norwegian Legal System
Authors: Offit Anna 
Published: December 2018

AbstractThe purpose of this article is to explore perceptions and assessments of lay participation in Norway during a historic time of transition away from all‐layperson juries. This study consisted of sixteen months of court observation and interviews with judges, prosecutors, former lay decision makers, defense attorneys, and other contributors to the country's longstanding jury debate. My ethnographic research demonstrates that all‐layperson juries in Norway face practical and procedural checks that differentiate them from Anglo‐American juries, among others. For this reason, legal professionals in Norway evince confidence that mixed courts of lay and professional citizens can facilitate fair case outcomes. A central finding from this research is that comparative analyses of all‐layperson juries and mixed courts require attention to the social specificity of the states that support such systems. To this end, lay participation in Norway challenges the conventional wisdom that jurors have greater independence and control over case outcomes than lay judges.
Social determinants of health and adverse maternal and birth outcomes in adolescent pregnancies: A systematic review and meta‐analysis
Authors: Amjad Sana , MacDonald Isaiah , Chambers Thane , Osornio‐Vargas Alvaro , Chandra Sujata , Voaklander Don , Ospina Maria B. 
Published: December 2018

AbstractBackgroundAdverse outcomes in adolescent pregnancies have been attributed to both biological immaturity and social determinants of health (SDOH). The present systematic review evaluated the evidence on the association between SDOH and adverse maternal and birth outcomes in adolescent mothers.MethodsComprehensive literature searches were conducted to identify observational studies evaluating the relationship between SDOH and adverse adolescent pregnancy outcomes. Study selection, risk of bias appraisal, and data extraction of study characteristics were independently performed by two reviewers. Pooled odds ratios (pOR) with 95% confidence intervals (95% CI) were calculated to assess the association between SDOH and adverse birth outcomes.ResultsThirty‐one studies met the inclusion criteria. The most frequently evaluated SDOH was race while the most commonly reported maternal and birth outcomes were caesarean section and preterm birth (PTB), respectively. The risk of bias of included studies was fair on the Newcastle‐Ottawa Scale. Meta‐analyses of retrospective cohort studies showed that, compared to White adolescent mothers, African American teens had increased odds of PTB (pOR 1.67; 95% CI 1.59, 1.75) and low birthweight (pOR 1.53; 95% CI 1.45, 1.62). Rural residence was consistently linked with PTB while low maternal socio‐economic (SES) and illiteracy were found to increase the risk of adolescent maternal mortality and LBW infants.ConclusionSocial determinants of health contribute to the risk of adverse pregnancy outcomes in adolescent mothers. African American race, rural residence, inadequate education, and low SES are markers for poor pregnancy outcomes in adolescent mothers. Further research needs to be done to understand the underlying causal pathways to inequalities in adolescent pregnancy outcomes.
Toxic Speech: Inoculations and Antidotes
Authors: Tirrell Lynne 
Published: December 2018

AbstractToxic speech inflicts individual and group harm, damaging the social fabric upon which we all depend. To understand and combat the harms of toxic speech, philosophers can learn from epidemiology, while epidemiologists can benefit from lessons of philosophy of language. In medicine and public health, research into remedies for toxins pushes in two directions: individual protections (personal actions, avoidances, preventive or reparative tonics) and collective action (specific policies or widespread “inoculations” through which we seek herd immunity). This paper is the beginning of a project of identifying potential inoculations and antidotes to toxic speech. The essay brings a social practice theory of language, with special reliance on language‐games and inferential roles, into conversation with concepts from the study of biologic toxins. Some speech harms are acute while others are chronic and insidious; they have different methods of delivery, come in variable doses, and not everyone is equally susceptible to the power to harm. I argue that of the many kinds of challenges we might issue against toxic speech, challenging its expressive commitments has the greatest potential to stop the damage. The essay explores the different sorts of protections that inoculations and antidotes might offer against discursive toxins and sketches how to imagine these in the practices that govern our speech. The paper does not make policy recommendations, but an epidemiology of discursive toxicity reveals several kinds of “more speech” that might fight against “bad speech.”
Slurs, Interpellation, and Ideology
Authors: Kukla Rebecca 
Published: December 2018

AbstractThe goal of this paper is to give an account of the pragmatic and social function of slurs, taken as speech acts. I develop a theory of the distinctive illocutionary force and pragmatic structure of slurs. I argue that slurs help to produce subjects who occupy social identities carved out by pernicious ideologies, and that they do this whether or not anyone involved intends for the slur to work that way or has any particular feelings or conscious thoughts associated with using or being targeted by the slur. I offer an Althusser‐inspired account of what an ideology is, as well as of the mechanisms by which slurs can serve to cue and strengthen ideologies. A slur, I argue, is a kind of interpellation, which reduces its target to a generic identity and derogates and subordinates its target. I explore how slurs and ideologies work in tandem to constitute and fortify one another. I end by applying my account to see how well it fits and helps illuminate three quite different, especially complex slurs.
Excerpt from Vexy Thing: On Gender and Liberation
Authors: Perry Imani 
Published: December 2018

AbstractThis article comes from three different sections from the forthcoming Vexy Thing: On Gender and Liberation, which focus on the terms: personhood, patriarchy, and feminism, and the connection to language and power. The first part of the book is a historically‐based conceptual account of the foundation of patriarchy, and the second part explores the shifts in patriarchy unfold in the hypermedia neoliberal age.
Protective legislation: The “third pillar” of the welfare state
Authors: Olsen Gregg M. 
Published: December 2018

AbstractWelfare states are built upon three central social policy pillars: (1) income programs, including an assortment of income maintenance and security benefits; (2) social services, comprising a diverse constellation of provisions, which furnish care such as health care and education, and “in kind” benefits; and (3) protective legislation, encompassing a dense web of proactive and preventative laws, rights, and entitlements, such as health and safety legislation, minimum wage laws, child protection acts, rent controls, and laws governing evictions and foreclosures. Despite its centrality to the welfare state and to our well‐being, this third pillar has received considerably less attention in comparative social policy research. The dominant welfare state typologies have focused almost exclusively upon income measures and, more recently, on social services, to construct their welfare state categories or “worlds” of welfare while largely neglecting this crucial third pillar. A greater focus on protective welfare legislation can help sharpen the distinctions among welfare states within and across the welfare worlds, which is particularly valuable in light of the ongoing erosion of the other two pillars over the past few decades.
The application of the carcinogenic hazardous property assessment to oil contaminated dredging waste
Authors: Jackson Karen , Nathanail Paul 
Published: December 2018

AbstractThe carcinogenic hazardous property assessment for oil contaminated waste is inappropriate when applied to canal and river dredgings. The presence of polyaromatic hydrocarbons (PAH) derived from non‐oil sources means that Benzo(a)Pyrene concentrations cannot be assumed to be markers for the carcinogenicity of any oil contaminants present. Canal dredgings can be suitable for use in a residential without homegrown produce land use whilst also being classified as ‘carcinogenic’ waste. A revision of the basis on which waste is classified as hazardous or non‐hazardous is needed, at least for canal and river dredgings which may contain PAH from several pyrogenic and petrogenic sources. Such a basis could simply refer to a concentration of PAH or individual congeners reflecting risk‐based assessment criteria.
Examining the effectiveness of examination at 6–8 weeks for developmental dysplasia: testing the safety net
Authors: Reidy Mike , Collins Caitlin , MacLean Jamie G B , Campbell Donald 
Published: December 2018

Objective
The ‘GP check’ at 6–8 weeks forms part of the selective surveillance system for developmental dysplasia of the hip (DDH) in the UK. It is imperative to pick up DDH within the first months of life to allow for non-invasive treatment and the avoidance of surgery. We aim to investigate the effectiveness of hip examination at 6–8 weeks.

Methods
This is a longitudinal observational study including all infants born in our region in the 5 years following 2006. Early presentation was defined as diagnosis within 14 weeks of birth and late presentation after 14 weeks. Treatment records for early and late DDH as well as referrals for ultrasound (US) following examination at 6–8 weeks were analysed. Attendance of the examination at 6–8 weeks in those patients who went on to present with a late DDH was also analysed.

Results
23 112 live births occurred during the study period. There were 141 confirmed cases of DDH. 400 referrals for US were received following examination at 6–8 weeks; 6 of these had a positive finding of DDH. 27 patients presented after 14 weeks and were classified as late presentations. 25 of these patients had attended examination at 6–8 weeks and no abnormality had been identified.

Conclusions
The sensitivity of examination at 6–8 weeks was only 19.4%, its specificity was 98% and it had a positive predictive value of 1.5%. For many years the check at 6–8 weeks has been thought of as a means to identify those children not identified as neonates; however, we found that four out of five children with DDH were not identified by the check at 6–8 weeks. Unfortunately, we conclude that the presumed safety net of the examination in its current form is not reliable.