bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of a Pharmacy-Initiated Inpatient Diabetes Patient Education Program on 30-Day Readmission Rates
Authors: Murphy Julie A. , Schroeder Michelle N. , Ridner Anita T. , Gregory Megan E. , Whitner Jangus B. , Hackett Sean G. 
Published: February 2019

Background: In October 2012, a pharmacy-driven Inpatient Diabetes Patient Education (IDPE) program was implemented at the University of Toledo Medical Center (UTMC). Objective: To determine the difference in 30-day hospital readmission rates for patients who receive IDPE compared to those who do not. Methods: This retrospective cohort was completed at UTMC. Patients admitted between October 1, 2012, and September 30, 2013, were included if they were ≥18 years and had one of the following: (1) diagnosis of diabetes mellitus, (2) blood glucose >200 mg/dL (>11.11 mmol/L) on admission, or (3) hemoglobin A1C of >6.5% (>48 mmol/mol). Patients who received IDPE from a pharmacist or student pharmacist (intervention group) were compared to patients who did not receive IDPE (control group). Results: The 30-day readmission rate was 13.2% for the intervention group (n = 364) and 21.5% for the control group (n = 149) ( P = .023). Average time to 30-day readmission was 13.1 (±8.3) days for the IDPE group and 11.9 (±7.9) days for the control group. There was no significant difference in diabetes-related readmission between the intervention and control groups (25.5% vs 21.9%). Conclusions: An IDPE program delivered primarily by pharmacists and student pharmacists significantly reduced 30-day readmission rates among patients with diabetes.
Corneoscleral xanthogranuloma treated with chemotherapy: The room for nonsurgical management
Authors: Mustafa Osama M , Daoud Yassine J 
Published: February 2019

Purpose: To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy. Methods: Interventional case report and literature search. Results: A 9-year-old female patient with a disseminated disease showed complete regression of her corneoscleral xanthogranuloma with methotrexate and azathioprine therapy. Conclusion: Since they are potentially blinding, corneoscleral xanthogranulomas are commonly surgically excised. While surgical resection has been widely advocated in the literature, immunosuppressive therapy alone may be a pertinent management line of corneoscleral xanthogranuloma, especially with systemic involvement.
Bio-Field Array: The Influence of Junction Mediating and Regulatory Protein Expression on Cytoskeletal Filament Behavior During Apoptosis in Triple-Negative Breast Cancer
Authors: Purnell Marcy C 
Published: February 2019

Introduction: The Bio-Field Array (BFA) is a device that generates a dielectrophoretic electromagnetic field (DEP-EMF) when placed in a hypotonic saline solution and a direct current (dc) of ~3 amperes is applied. Human triple-negative breast cancer (MDA-MB-231 cells) is known to have a high percentage of apoptotic ( P53) deficient cells and some patients can have poor outcomes with current treatments. Objectives: Previously, we reported a strong upregulation of the apoptotic arm of the unfolded protein response, via reverse transcription–quantitative polymerase chain reaction (RT-qPCR), as well as positive annexin staining in this human breast carcinoma, when grown in media prepared with BFA’s dc DEP-EMF treated saline. Here we will examine and discuss cytoskeletal microtubule changes that were noted in the treated breast carcinoma that are strongly suggestive of apoptosis and the possible correlation of these microtubule changes to the upregulation of Junction Mediating and Regulatory Protein ( JMY, a P53/TP53 cofactor) that is known to drive cytoskeleton microfilaments (actin) function. Methods: In addition to microarray and RT-qPCR analyses, we conducted 7 days of fluorescent microscopic analyses of tubulin assays in these treated versus control MDA-MB-231 cells. Results: These data suggest 2 possible forms of apoptosis, rounded and irregular, may be occurring and possibly facilitated by the significant upregulation (via microarray and RT-qPCR) of an important but poorly understood Nucleation-Promoting Factor (NPF), JMY. Conclusions: The ability of the BFA dc DEP-EMF to significantly upregulate JMY and possibly influence the regulation of unbranched (nucleation-microtubule spikes) and branched forms (autophagy) of actin in the cytoplasmic domains may facilitate a “two coffins” or round and irregular necrosis-like apoptosis for this highly aggressive and often apoptotic-deficient breast cancer cell line.
Madelung’s deformity: capitate-related versus ulna-related measurement methods
Authors: Hegazy Galal , Mansour Tarek , Alshal Ehab , Abdelaziz Mohammed , Alnahas Mohammed , El-Sebaey Ibrahem 
Published: February 2019

Several investigators have defined measurements for Madelung’s deformity based on the distal radius or on the longitudinal ulnar axis to avoid the distorted distal radius and its lunate fossa. However, errors may occur in severe cases because of ulnar deformity and displacement. We quantified seven established measurements for Madelung’s deformity relying on the central axis of the capitate. The inter- and intrarater reliability of the capitate-related and the ulna-related techniques were compared. We observed a higher inter- and intrarater reliability for the capitate-related method than for the ulna-related method. Better agreement was also observed for measurements of distance than for measurements of angles. However, the palmar tilt angle measurement method was neither reliable nor reproducible. The capitate-related technique can help to accurately determine the severity of Madelung’s deformity, assist in surgical planning and identify the prognosis. Level of evidence: III
Accuracy of the new rapid test for monitoring adalimumab levels
Authors: Rocha Cátia , Afonso Joana , Lago Paula , Arroja Bruno , Vieira Ana I. , Dias Claudia C. , Magro Fernando 
Published: February 2019

Background: The loss of response to adalimumab (ADL) has been related to low serum concentrations at trough. Currently, most methods commercially available for the quantification of ADL are enzyme-linked immunosorbent assay (ELISA) based, with a turnaround time of approximately 8 h, delaying the target dosage adjustment to the subsequent infusion. In this study, we aimed to evaluate the performance of the newly available rapid-test ADL quantification assay by comparing it with three established ELISA methods, using spiked samples and a set of clinical samples. Methods: Spiked samples from control donors and 120 serum samples from inflammatory bowel disease (IBD) patients undergoing ADL therapy were quantified using lateral flow Quantum Blue® Adalimumab and, the ELISA formats from Immundiagnostik, R-Biopharm and an in-house assay. Results: The rapid-test assay had intraclass correlation coefficients of 0.590, 0.864 and 0.761 when comparing with the Immundiagnostik, R-Biopharm and in-house assays, respectively. For the five therapeutic windows, the accuracy was high: ADL rapid test compared with the Immundiagnostik (58–88%); R-Biopharm, 68–89%; and in house, 60–88%; and kappa statistics revealed 0.492–0.602, 0.531–0.659 and 0.545–0.682, respectively. Conclusions: The Quantum Blue® Adalimumab assay can replace the commonly used ELISA-based ADL quantification kits and it is a reliable alternative to these methods. This rapid-test assay enables the quantitative determination of ADL serum trough level in only 15 min. The developed assay allows measurement of ADL over a wide range. Hence, it represents a valuable tool for the clinician to assess the ADL trough level.
The revised Atlanta criteria more accurately reflect severity of post‐ERCP pancreatitis compared to the consensus criteria
Authors: Smeets XJNM , Bouhouch N , Buxbaum J , Zhang H , Cho J , Verdonk RC , Römkens TEH , Venneman NG , Kats I , Vrolijk JM , Hemmink GJM , Otten A , Tan ACITL , Elmunzer BJ , Cotton PB , Drenth JPH , van Geenen EJM 
Published: February 2019

Background and objectivePost‐endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is the most prevalent complication after ERCP with an incidence of 3.5%. PEP severity is classified according to either the consensus criteria or the revised Atlanta criteria. In this international cohort study we investigated which classification is the strongest predictor of PEP‐related mortality.MethodsWe reviewed 13,384 consecutive ERCPs performed between 2012 and 2017 in eight hospitals. We gathered data on all pancreatitis‐related adverse events and compared the predictive capabilities of both classifications. Furthermore, we investigated the correlation between the two classifications and identified reasons underlying length of stay.ResultsThe total sample consisted of 387 patients. The revised Atlanta criteria have a higher sensitivity (100 vs. 55%), specificity (98 vs. 72%) and positive predictive value (58 vs. 5%). There is a significant difference (p < 0.001) between the two classifications. In 124 patients (32%), the length of stay was influenced by concomitant diseases.ConclusionThe revised Atlanta classification is superior in predicting mortality and better reflects PEP severity. This has important implications for researchers, clinicians and patients. For the diagnosis of PEP pancreatitis, the consensus criteria remain the golden standard. However, the revised Atlanta criteria are preferable for defining PEP severity.
Extra-articular, Intraepiphyseal Drilling for Osteochondritis Dissecans of the Knee: Characterization of a Safe and Reproducible Surgical Approach
Authors: Lee Cody S. , Larsen Christopher G. , Marchwiany Daniel A. , Chudik Steven C. 
Published: February 2019

Background: Osteochondritis dissecans (OCD) is an idiopathic focal condition affecting the subchondral bone of joints, and it is increasingly prevalent among the active young adult population. For lesions that have failed nonoperative management, transarticular drilling and extra-articular drilling are surgical options. Although the extra-articular approach preserves the articular cartilage, it is technically challenging and could benefit from a study of surgical approach. Purpose: To use 3-dimensional modeling of magnetic resonance imaging (MRI) scans from skeletally immature individuals to characterize safe tunnel entry points, trajectories, and distances from the physeal and articular cartilage along the course of the distal femoral epiphysis to the OCD target in their most common location of the medial femoral condyle (MFC). Study Design: Descriptive laboratory study. Methods: A total of 17 MRI scans from skeletally immature patients were used to create 3-dimensional models of the knee joint. Virtual representations of an OCD lesion were placed in the lateral aspect of the MFC; cylinders simulating tunnel length, diameter, and trajectory were superimposed onto the models; and measurements were taken. Results: Two safe tunnels were identified, 1 anterior and 1 posterior to the medial collateral ligament (MCL). The anterior tunnel had a diameter of 10.3 ± 1.4 mm, skin entry point of 16.9 ± 12.1 mm anterior and 7.1 ± 5.9 mm superior to the medial epicondyle, bony entry point of 12.1 ± 3.5 mm anterior and 2.4 ± 3.5 mm inferior to the medial epicondyle, and tunnel length of 31.8 ± 3.7 mm. The posterior tunnel had a diameter of 7.8 ± 1.8 mm, skin entry point of 9.4 ± 5.1 mm posterior and 26.0 ± 14.0 mm superior to the medial epicondyle, bony entry point of 8.6 ± 2.6 mm posterior and 5.1 ± 4.2 mm superior to the medial epicondyle, and tunnel length of 33.5 ± 4.5 mm. Conclusion: This anatomic characterization study identifies and defines 2 safe and reproducible tunnel approaches, 1 anterior and 1 posterior to the MCL, for drilling or creating tunnels to OCD lesions of the MFC in an extra-articular fashion. Clinical Relevance: The study findings provide valuable anatomic references for surgeons performing extra-articular drilling or tunneling of OCD lesions.
Carfilzomib or bortezomib with melphalan-prednisone for transplant-ineligible patients with newly diagnosed multiple myeloma
Authors: Facon Thierry , Lee Jae Hoon , Moreau Philippe , Niesvizky Ruben , Dimopoulos Meletios , Hajek Roman , Pour Ludek , Jurczyszyn Artur , Qiu Lugui , Klippel Zandra , Zahlten-Kumeli Anita , Osman Muhtarjan , Paiva Bruno , San-Miguel Jesus 
Published: February 2019

Abstract
The phase 3 CLARION study compared carfilzomib-melphalan-prednisone (KMP) with bortezomib-melphalan-prednisone (VMP) in transplant-ineligible newly diagnosed multiple myeloma (NDMM) patients. Patients were randomized 1:1 to KMP or VMP for nine 42-day cycles (C). Patients received carfilzomib on days (D) 1, 2, 8, 9, 22, 23, 29, 30 (20 mg/m2: C1D1, C1D2; 36 mg/m2 thereafter) or bortezomib on D1, 4, 8, 11, 22, 25, 29, 32 (1.3 mg/m2; D4, 11, 25, 32 omitted for C5-9). Melphalan (9 mg/m2) and prednisone (60 mg/m2) were administered on D1-4. The primary endpoint was progression-free survival (PFS). Nine hundred fifty-five patients were randomized (intention-to-treat population: KMP, n = 478; VMP, n = 477). Median PFS was 22.3 months with KMP vs 22.1 months with VMP (hazard ratio [HR], 0.906; 95% confidence interval [CI], 0.746-1.101; P = .159). Median overall survival was similar and not reached in either group (HR, 1.08; 95% CI, 0.82-1.43). Overall response rate was 84.3% for KMP and 78.8% for VMP. Complete response rate was 25.9% for KMP and 23.1% for VMP. Minimal residual disease–negative rates were 15.7% (KMP) and 15.5% (VMP). Adverse events (AEs) of interest (any grade) occurring with a ≥5% higher patient incidence in the KMP arm were acute renal failure (13.9% [KMP] vs 6.2% [VMP]) and cardiac failure (10.8% vs 4.3%). Grade ≥3 AE rates were 74.7% (KMP) and 76.2% (VMP). Grade ≥2 peripheral neuropathy was lower for KMP vs VMP (2.5% vs 35.1%). Treatment with KMP in CLARION did not yield a statistically significant difference in PFS vs VMP. This trial was registered at www.clinicaltrials.gov as #NCT01818752.
Centrally located lung cancer and risk of occult nodal disease: an objective evaluation of multiple definitions of tumour centrality with dedicated imaging software
Authors: Casal Roberto F. , Sepesi Boris , Sagar Ala-Eddin S. , Tschirren Juerg , Chen Minxing , Li Liang , Sunny Jennifer , Williams Joyce , Grosu Horiana B. , Eapen George A. , Jimenez Carlos A. , Ost David E. 
Published: February 2019

IntroductionCurrent guidelines recommend invasive mediastinal staging in patients with centrally located radiographic stage T1N0M0 nonsmall cell lung cancer (NSCLC). The lack of a specific definition of a central tumour has resulted in discrepancies among guidelines and heterogeneity in practice patterns.MethodsOur objective was to study specific definitions of tumour centrality and their association with occult nodal disease. Pre-operative chest computed tomography scans from patients with clinical (c) T1N0M0 NSCLC were processed with a dedicated software system that divides the lungs in thirds following vertical and concentric lines. This software accurately assigns tumours to a specific third based both on the location of the centre of the tumour and its most medial aspect, creating eight possible definitions of central tumours.Results607 patients were included in our study. Surgery was performed for 596 tumours (98%). The overall pathological (p) N disease was: 504 (83%) N0, 56 (9%) N1, 47 (8%) N2 and no N3. The prevalence of N2 disease remained relatively low regardless of tumour location. Central tumours were associated with upstaging from cN0 to any N (pN1/pN2). Two definitions were associated with upstaging to any N: concentric lines, inner one-third, centre of the tumour (OR 3.91, 95% CI 1.85–8.26; p<0.001) and concentric lines, inner two-thirds, most medial aspect of the tumour (OR 1.91, 95% CI 1.23–2.97; p=0.004).ConclusionsWe objectively identified two specific definitions of central tumours. While the rate of occult mediastinal disease was relatively low regardless of tumour location, central tumours were associated with upstaging from cN0 to any N.
High content screening for drug discovery from traditional Chinese medicine
Authors: Wang Jing , Wu Ming-Yue , Tan Jie-Qiong , Li Min , Lu Jia-Hong 
Published: February 2019

AbstractTraditional Chinese medicine (TCM) represents the crystallization of Chinese wisdom and civilization. It has been valued as the renewable source for the discovery of novel drugs, owing to its long-term proved efficacy in human diseases and abundant biologically active components pools. To dissect the mystery of TCM, modern technologies such as omics approaches (proteomics, genomics, metabolomics) and drug screening technologies (high through-put screening, high content screening and virtual screening) have been widely applied to either identify the drug target of TCM or identify the active component with certain bio-activity. The advent of high content screening technology has absolutely contributed to a breakthrough in compounds discovery and influenced the evolution of technology in screening field. The review introduces the concept and principle of high content screening, lists and compares the currently used HCS instruments, and summarizes the examples from ours and others research work which applied HCS in TCM-derived compounds screening. Meanwhile, this article also discusses the advantages and limitations of HSC technology in drug discovery from TCM libraries.
TRPM7 promotes the epithelial–mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling
Authors: Liu Lu , Wu Nayiyuan , Wang Ying , Zhang Xiaoyun , Xia Bing , Tang Jie , Cai Jingting , Zhao Zitong , Liao Qianjin , Wang Jing 
Published: February 2019

Abstract
Background
The epithelial-mesenchymal transition (EMT) is crucial for metastasis and positively regulated by calcium-related signaling. The melastatin-related transient receptor potential 7 (TRPM7) regulates a non-selective cation channel and promotes cancer metastasis. However, the mechanisms underlying the action of TRPM7 in ovarian cancer are unclear.

Methods
The expression of TRPM7 and EMT markers (Vimentin, N-cadherin, Twist and E-cadherin) in ovarian cancer samples was detected. TRPM7was knockdown by shRNA in Ovarian cancer cell lines to examine calcium [Ca2+]i, EMT markers and PI3K/AKT markers. Various cellular assays, such as invasion and migration, were performed in vitro, and further confirmed in vivo.

Results
TRPM7 expression is negatively correlated with E-cadherin, but positively with N-cadherin, Vimentin and Twist expression in ovarian cancer samples. TRPM7 depletion inhibited the migration and invasion in SKOV3 and OVCAR3 cells. In addition, TRPM7 silencing decreased the lung metastasis of SKOV3 tumors and prolonged the survival of tumor-bearing mice. Similar to that of TRPM7 silencing, treatment with MK886, a potent 5-lipoxygenase inhibitor to reduce TRPM7 expression, and/or BAPTA-AM, an intracellular calcium chelator, significantly mitigated the Epidermal growth factor (EGF) or Insulin-like growth factors (IGF)-stimulated migration, invasion, and the EMT in ovarian cancer cells by decreasing the levels of intracellular calcium [Ca2+]i. Furthermore, treatment with LY2904002, a PI3K inhibitor, also inhibited the migration, invasion, and treatment with both LY2904002 and BAPTA-AM further enhanced their inhibition in ovarian cancer cells. Moreover, treatment with BAPTA-AM mitigated the IGF-stimulated migration, invasion, particularly in TRPM7-silenced ovarian cancer cells. Finally, TRPM7 silencing attenuated the PI3K/AKT activation, which was enhanced by BAPTA-AM, MK886 or LY2904002 treatment in ovarian cancer cells.

Conclusions
TRPM7 silencing inhibited the EMT and metastasis of ovarian cancer by attenuating the calcium-related PI3k/AKT activation. Our findings suggest that TRPM7 may be a therapeutic target for intervention of ovarian cancer.
MIGHT PLIGHT: THE SOCIAL ANXIETY FELT BY MEN IN THE WEIGHTLIFTING ENVIRONMENT
Authors: Cyr Alex , Munroe-Chandler Krista , Gammage Kimberley 
Published: February 2019

Apply It!
Be aware of the specific elements and scenarios in your fitness facility that may elicit anxiety in men and work to improve the environment to eliminate or alleviate those feelings of anxiety. Be especially aware of these scenarios in gyms where there might be a number of clients who are bodybuilders.
Consider the development of all-male fitness classes to alleviate perceived anxiety and encourage physical activity in men.
Consider the physical space and the addition of equipment in your fitness facility to eliminate conflicts over resources.
O conselheiro do mercado
Authors: Wilner Adriana , Dos Santos Aline Lilian 
Published: February 2019

Desde os anos 1980, Guilherme Affonso Ferreira é um importante investidor de longo prazo no mercado de ações no Brasil. Compra participações relevantes o suficiente para ter direito a uma cadeira no conselho de administração de grandes empresas. Foi assim em dezenas de casos, como Pão de Açúcar, Metal Leve, Eternit, Manah, Gafisa e Unibanco.Nesta entrevista exclusiva à GV-executivo, Guilherme compartilha sua trajetória, experiência, desafios e aprendizados nomercado de ações brasileiro. Ele também fala sobre seus melhores investimentos e quais setores considera promissores para se apostar nos próximos anos.
Comparison of Weight-for-Height Z-score and mid-upper arm circumference to diagnose moderate and severe acute malnutrition in children aged 6-59 months
Authors: Bari Attia , Nazar Mubeen , Iftikhar Aisha , Mehreen Sana 
Published: February 2019

Objective: To compare weight for height (WHZ) and mid upper arm circumference (MUAC) to diagnose malnutrition in children aged 6–59 months and to determine the association of various risk factors with the nutritional status of the children.
Methods: Descriptive study conducted at the Department of Paediatric Medicine of The Children’s Hospital Lahore from May 2017 to April 2018. A total of 257 children 6 to 59 months of age having MUAC of <125mm were included. WHZ scoring was done and compared with MUAC.
Results: There was slight male predominance 135 (52.5%). Mean age of children was 13.43 + 8.81 months (95% CI: 12.34-14.51). Mean MUAC was 103±13.5 mm (95%CI: 101-105mm). Exclusive breast feeding was present in 82 (32%). Maternal illiteracy was common in SAM (p = was 0.001). More children (73.2%) were identified as SAM by MUAC of <115 mm as compared to WHZ of <-3SD (70%). The ROC curve analysis for MUAC (cut-off value:103, 95%CI; AUC: 101-107 mm) showed it as an excellent predictor (p=<0.001) for children having SAM and WHZ <-3SD, with (AUC= 0.786 [95%CI; 0.725-0.848]).
Conclusion: Both MUAC and WHZ showed fair degree of agreement to diagnose moderate and severe acute malnutrition among children aged 6–59 months. At the community level of resource limited countries, MUAC can be used as an appropriate rapid diagnostic method to identify malnourished children to be managed in nutritional rehabilitation programs.
How to cite this:Bari A, Nazar M, Iftikhar A, Mehreen S. Comparison of Weight-for-Height Z-score and mid-upper arm circumference to diagnose moderate and severe acute malnutrition in children aged 6-59 months. Pak J Med Sci. 2019;35(2):337-341. doi: https://doi.org/10.12669/pjms.35.2.45
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