bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attitudes towards health research participation: a qualitative study of US Arabs and Chaldeans
Authors: Campbell-Voytal Kimberly D , Schwartz Kendra L , Hamade Hiam , Dallo Florence J , Neale Anne Victoria 
Published: August 2018

Abstract

Background
The Arab Muslim and Chaldean Christian American community is unified by language but culturally diverse. Researchers are challenged to engage the Arab/Chaldean community to meet immigrant health needs. Arabs/Chaldeans are identified as white in clinical data sets making it difficult to identify health behaviours and patterns unique to the community.

Objectives
To explore the views of members of the Arab/Chaldean community, including researchers and the lay public, regarding health research participation and the role of clinicians, researchers and community leaders in the research process.

Methods
A qualitative study of Arab and Chaldean adults and researchers conducted in a US community with a large Arab/Chaldean population. Five semi-structured focus group discussions were triangulated with five in-depth semi-structured interviews with Arab or Chaldean primary care researchers. Responses were audio-recorded and transcribed verbatim. Transcripts were coded and thematically analysed, and findings confirmed with community representatives.

Results
Three themes were identified: (i) research expectations: risks and benefits; (ii) health care environment: clinicians as recruiters and (iii) research participations: risks and benefits. Themes captured concerns with social relationships, reputation or trust and the cost and benefit of research participation. In the Arab/Chaldean community, institutional and political fears and distrust are amplified. Respect for physicians, teachers and faith leaders connected with or recruiting for studies enhances likelihood of research participation.

Conclusion
Clinical researchers should address the cultural and immigration histories of Arab/Chaldean research participants. Studies that maximize trust will minimize participation bias and lay the groundwork for improved health. Institutional, sociocultural and personal factors require a pre-study phase to engage and educate participants.
Chronobiology and the design of marine biology experiments
Authors: Mat Audrey M 
Published: August 2018

AbstractMarine habitats are shaped by several geophysical cycles ranging from a few hours (tidal and solar cycles) to a year (seasons). These cycles have favoured the selection of endogenous biological clocks. Such a clock is a molecular time-keeping mechanism that consists of a set of core clock genes whose expression oscillates. The clocks produce biological rhythms and influence virtually all metabolic, physiological, and behavioural functions in organisms. This work highlights the importance to take chronobiology into account in experimental marine biology to avoid faulty results, misinterpretation of results, and/or to strengthen observations and conclusion. A literature survey, based on 150 articles, was conducted and showed that, despite the pervasive imprint of biological rhythms in marine species, environmental cycles such as the 24 h-light/dark cycle and the seasonality are rarely considered in experimental designs. This work emphasizes that better integrating the temporal organization and regulation of marine species within the marine biology community is essential for obtaining representative results.
Sustainable use of Baltic Sea resources
Authors: Ojaveer Henn , Neuenfeldt Stefan , Dierking Jan , Eek Liina , Haldin Jannica , Martin Georg , Märtin Kaire , Peterson Kaja , Valanko Sebastian 
Published: August 2018

Abstract
The BONUS symposium “Science delivery for sustainable use of the Baltic Sea living resources” held in Tallinn, Estonia, in October 2017 was an opportunity for the presentation and discussion of 107 papers that examined the state and dynamics of living resources of the Baltic Sea, and associated management challenges. The symposium included a half-day stakeholder panel discussion that addressed the main challenges related to sustainable management and matching research and policy/management needs. Based on the five symposium papers published in this Special Issue as well as the stakeholder panel discussion, it can be concluded that (i) new observations about the feeding ecology of clupeids supports a more complete understanding of trophic interactions in the pelagic realm and improved calibration of ecosystem models, (ii) to safequard sustainable and diverse fisheries resources, one should take into account the specific local characteristics of the fish community, (iii) to safeguard sustainable use of marine resources and mitigate cross-sectoral and transboundary conflicts, a risk-based approach should be adopted, and (iv) incorporation of scientific advice into management faces several obstacles including the reality that not all readily available knowledge is currently being incorporated into the decision-making process.
Dysregulation of immunoproteasomes in autoinflammatory syndromes
Authors: Yasutomo Koji 
Published: August 2018

Abstract
Immunoproteasomes degrade ubiquitin-coupled proteins and play a role in creating peptides for presentation by MHC class I proteins. Studies of gene-deficient mice, in which each immunoproteasomal subunit was affected, have demonstrated that dysfunction of immunoproteasomes leads to immunodeficiency, i.e. reduced expression of MHC class I and attenuation of CD8 T-cell responses. Recent studies, however, have uncovered a new type of autoinflammatory syndrome characterized by fever, nodular erythema and progressive partial lipodystrophy that is caused by genetic mutations in immunoproteasome subunits. These mutations disturbed the assembly of immunoproteasomes, which led to reduced proteasomal activity and thus accumulation of ubiquitin-coupled proteins. Those findings suggest that immunoproteasomes function as anti-inflammatory machinery in humans. The discovery of a new type of autoinflammatory syndrome caused by dysregulated immunoproteasomes provides novel insights into the important roles of immunoproteasomes in inflammation as well as the spectrum of autoinflammatory diseases.
Racializing Religion: Constructing Colonial Identities in the Syrian Provinces in the Nineteenth Century
Authors: Delatolla Andrew , Yao Joanne 
Published: August 2018

AbstractIn recent decades, international events and incisive critical voices have catapulted the concepts of race and religion to the foreground of International Relations research. In particular, scholars have sought to recover the racialized and imperial beginnings of IR as an academic discipline in the early-20th century. This article contributes to this growing body of work by analyzing both race and religion as conceptual tools of scientific imperial administration—tools that in the 19th century classified and divided the global periphery along a continuum of civilizational and developmental difference. The article then applies this framework to the case of French, and more broadly, European, relations with populations in the Ottoman Empire, particularly within the Syrian Provinces. As described throughout this article and the case study, the Europeans used the language of race to contribute to religious hierarchies in the Syrian provinces in the mid- and late-19th century, having a lasting effect on discussions of religion in IR and international politics.
Integration Processes of Syrian Refugees in Turkey: ‘Class-based Integration’
Authors: ŞİMŞEK DOĞUŞ 
Published: August 2018

Abstract
This article explores the intersections between economic resources of refugees and integration. It measures processes of adaptation of Syrians by focusing on the legal-political and socio-economic dimensions of integration. The focus of my analysis of the situations of Syrian refugees in Turkey is on class and related to financial resources that help Syrians to reach a kind of stability and security to those who lack rights. The key theoretical undertaking of this article is an attempt to develop the concept of ‘class-based integration’. The data consists of 120 semi-structured interviews conducted with Syrian refugees in Istanbul, Ankara and Gaziantep. I argue that Syrian refugees in Turkey go through ‘class-based integration’, which is in favour of refugees who do investments and who are skilled and leaves out refugees who are unskilled and do not have economic resources to invest in the receiving country from the integration processes. The article also shows that having economic resources could also support the construction of social bridges with members of the receiving society and overcoming the legal barriers to integration.
Pulsar timing constraints on the Fermi massive black hole binary blazar population
Authors: Holgado A Miguel , Sesana Alberto , Sandrinelli Angela , Covino Stefano , Treves Aldo , Liu Xin , Ricker Paul 
Published: August 2018

ABSTRACT
Blazars are a subpopulation of quasars whose jets are nearly aligned with the line of sight, which tend to exhibit multiwavelength variability on a variety of time-scales. Quasi-periodic variability on year-like time-scales has been detected in a number of bright sources, and has been connected to the orbital motion of a putative massive black hole binary. If this were indeed the case, those blazar binaries would contribute to the nanohertz gravitational-wave stochastic background. We test the binary hypothesis for the blazar population observed by the Fermi Gamma-Ray Space Telescope, which consists of BL Lacertae objects and flat-spectrum radio quasars. Using mock populations informed by the luminosity functions for BL Lacertae objects and flat-spectrum radio quasars with redshifts z ≤ 2, we calculate the expected gravitational-wave background and compare it to recent pulsar timing array upper limits. The two are consistent only if a fraction ≲10−3 of blazars hosts a binary with orbital periods &lt;5 yr. We therefore conclude that binarity cannot significantly explain year-like quasi-periodicity in blazars.
The nature of the variable millimetre–selected AGN in the brightest cluster galaxy of Abell 851
Authors: Cheale R A , Geach J E , Edge A C , Perrott Y C , Cantwell T 
Published: August 2018

ABSTRACT
We present the detection of a bright 3 mm continuum source in the brightest cluster galaxy (BCG) in Abell 0851 (z = 0.411) with the NOrthern Extended Millimeter Array (NOEMA). When this detection is compared to other multifrequency observations across 21cm–$100 {\mu {m}}$, including new Arcminute Microkelvin Imager 15 GHz observations, we find evidence for a relatively flat, variable core source associated with the BCG. The radio power and amplitude of variability observed in this galaxy is consistent with the cores in lower redshift BCGs in X-ray–selected clusters, and the flat mm–cm spectrum is suggestive of the BCG being a low-luminosity active galactic nucleus archetype. The discovery of this system could provide a basis for a long-term study of the role of low-luminosity radio mode ‘regulatory’ feedback in massive clusters.
Predicting kidney failure risk after acute kidney injury among people receiving nephrology clinic care
Authors: Sawhney Simon , Beaulieu Monica , Black Corri , Djurdjev Ognjenka , Espino-Hernandez Gabriela , Marks Angharad , McLernon David J , Sheriff Zainab , Levin Adeera 
Published: August 2018

Abstract

Background
Outcomes after acute kidney injury (AKI) are well described, but not for those already under nephrology clinic care. This is where discussions about kidney failure risk are commonplace. We evaluated whether the established kidney failure risk equation (KFRE) should account for previous AKI episodes when used in this setting.

Methods
This observational cohort study included 7491 people referred for nephrology clinic care in British Columbia in 2003–09 followed to 2016. Predictors were previous Kidney Disease: Improving Global Outcomes–based AKI, age, sex, proteinuria, estimated glomerular filtration rate (eGFR) and renal diagnosis. Outcomes were 5-year kidney failure and death. We developed cause-specific Cox models (AKI versus no AKI) for kidney failure and death, stratified by eGFR (&lt;/≥30 mL/min/1.73 m2). We also compared prediction models comparing the 5-year KFRE with two refitted models, one with and one without AKI as a predictor.

Results
AKI was associated with increased kidney failure (33.1% versus 26.3%) and death (23.8% versus 16.8%) (P  &lt; 0.001). In Cox models, AKI was independently associated with increased kidney failure in those with an eGFR ≥30 mL/min/1.73 m2 {hazard ratio [HR] 1.35 [95% confidence interval (CI) 1.07–1.70]}, no increase in those with eGFR &lt;30 mL/min/1.73 m2 ([HR 1.05 95% CI 0.91–1.21)] and increased mortality in both subgroups [respective HRs 1.89 (95% CI 1.56–2.30) and 1.43 (1.16–1.75)]. Incorporating AKI into a refitted kidney failure prediction model did not improve predictions on comparison of receiver operating characteristics (P = 0.16) or decision curve analysis. The original KFRE calibrated poorly in this setting, underpredicting risk.

Conclusions
AKI carries a poorer long-term prognosis among those already under nephrology care. AKI may not alter kidney failure risk predictions, but the use of prediction models without appreciating the full impact of AKI, including increased mortality, would be simplistic. People with kidney diseases have risks beyond simply kidney failure. This complexity and variability of outcomes of individuals is important.
Disentangling Within- and Between-Person Effects of Shared Risk Factors on E-cigarette and Cigarette Use Trajectories From Late Adolescence to Young Adulthood
Authors: Dunbar Michael S , Davis Jordan P , Rodriguez Anthony , Tucker Joan S , Seelam Rachana , D’Amico Elizabeth J 
Published: August 2018

Abstract

Background
Longitudinal studies report associations between use of electronic cigarettes (ECs) and cigarettes over time among young people, but do not distinguish within- from between-person effects, which complicates interpretation of findings. Further, the role of shared risk factors, such as substance use and mental health, in explaining longitudinal associations between EC and cigarette use remains unclear. This study used within- and between-person analyses to assess longitudinal associations between youths’ EC and cigarette use and shared risk factors.

Methods
Between 2015 and 2017, 2039 youths completed three Web-based surveys, allowing us to model EC and cigarette use from ages 16 to 20. Auto-regressive latent growth models with structured residuals (ALT-SR) examined both between-person and within-person associations between past-month frequency of EC use, cigarette use, and third variables (alcohol and marijuana use, mental health symptoms) over time.

Results
Models revealed robust reciprocal associations between EC and cigarette use, such that more frequent EC use at one time predicted more frequent cigarette use at the subsequent time, and vice versa. Between-person analyses showed associations between shared risk factors and both EC and cigarette use. However, shared risk factors did not predict frequency of subsequent EC and cigarette use in within-person analyses.

Conclusions
Findings add to a growing body of research suggesting that EC use among youth is prospectively associated with progression toward greater cigarette use. Shared risk factors may help explain differences in EC and cigarette use patterns between young people, but do not appear to influence longitudinal trajectories of EC and cigarette use within individuals.

Implications
This study examined within- and between-person associations between e-cigarette use, cigarette use, and shared risk factors (alcohol use, marijuana use, mental health symptoms) in a longitudinal cohort of youths. Within- and between-person analyses revealed reciprocal prospective associations between e-cigarette and cigarette use, suggesting a progression toward more frequent use of both products over time. The shared risk factors examined here did not affect escalations in e-cigarette or cigarette use over time within individuals, but likely influence which youths use these products. Findings add to a growing body of evidence suggesting that e-cigarette use increases subsequent cigarette use in young people.
Evaluation of a Randomized Clinical Trial Comparing the Effectiveness of a Culturally Targeted and Nontargeted Smoking Cessation Intervention for Lesbian, Gay, Bisexual, and Transgender Smokers
Authors: Matthews Alicia K , Steffen Alana D , Kuhns Lisa M , Ruiz Raymond A , Ross Nat A , Burke Larisa A , Li Chien Ching , King Andrea C 
Published: August 2018

Abstract

Purpose
To examine the benefits of a culturally targeted compared with a nontargeted smoking cessation intervention on smoking cessation outcomes among lesbian, gay, bisexual, and transgender (LGBT) smokers.

Methods
A prospective randomized design was used to evaluate the added benefits of an LGBT culturally targeted Courage to Quit (CTQ-CT) smoking cessation treatment (N = 172) compared with the standard intervention (CTQ; N = 173). The smoking cessation program consisted of six treatment sessions combined with 8 weeks of nicotine replacement therapy. The primary smoking cessation outcome was 7-day point prevalence quit rates. Secondary outcomes examined included changes in nicotine dependence, nicotine withdrawal, cigarettes per day, smoking urges, self-efficacy, and readiness to quit.

Results
Overall quit rates were 31.9% at 1 month, 21.1% at 3 months, 25.8% at 6 months, and 22.3% at 12 months. Quit rates did not differ between treatment groups [1 month OR = 0.81 (0.32, 2.09), 3 months OR = 0.65 (0.23, 1.78), 6 months OR = 0.45 (0.17, 1.21), 12 months OR = 0.70 (0.26, 1.91)]. Compared with baseline levels, all secondary smoking cessation outcomes measured were improved at 1 month and were maintained at 12-month follow-up. Compared with the CTQ, the CTQ-CT intervention was more highly rated on program effectiveness (d = 0.2, p = .011), intervention techniques (d = 0.2, p = .014), the treatment manual (d = 0.3, p < .001), and being targeted to the needs of LGBT smokers (d = 0.5, p < .0001).

Conclusions
LGBT smokers receiving the CTQ intervention achieved smoking cessation outcomes in the range reported for other demographic groups. Cultural targeting improved the acceptability of the intervention but did not confer any additional benefit for smoking cessation outcomes.

Implications
Study results have implications for understanding the benefits of culturally targeted compared with nontargeted smoking cessation interventions for improving smoking cessation outcomes among LGBT smokers. Shorter and longer term 7-day point prevalence quit rates associated with the targeted and nontargeted interventions were modest but comparable with other group-based interventions delivered in a community setting. Although cultural targeting improved the overall acceptability of the intervention, no added benefits were observed for the culturally targeted intervention on either the primary or secondary outcomes.
Metric semi-groups of normal states determine F-algebras
Authors: Lau Anthony To-Ming , Ng Chi-Keung , Wong Ngai-Ching 
Published: August 2018

Abstract
Let A be an F-algebra and S(A*) be the metric semi-group of normal states of the W*-algebra A*. We show that S(A*) determines A, when A* is of type I. In particular, when A is either the Fourier algebra A(G) or the Fourier–Stieltjes algebra B(G) of a type I locally compact group G, the metric semi-group S(A*) determines G up to opposition. A remark for the general case will also be given.
Impact of RSV Coinfection on Human Bocavirus in Children with Acute Respiratory Infections
Authors: Sun Huiming , Sun Jiyang , Ji Wei , Hao Chuangli , Yan Yongdong , Chen Zhengrong , Wang Yuqing 
Published: August 2018

Abstract

Objective
The objective of this study was to assess epidemiological and clinical features of human bocavirus (HBoV) coinfection with other viruses.

Method
Children coinfected with HBoV between January 2012 and December 2014 were enrolled and retrospectively reviewed.

Result
A total of 984 patients were stratified into five groups: HBoV infection alone (n = 249), respiratory syncytial virus (RSV) infection alone (n = 649), HBoV coinfection with RSV (n = 28), with human rhinovirus (HRV) (n = 39) and with other virus (n = 19). Length of hospitalization was longer in HBoV coinfection with RSV group than HBoV (9.0 days vs. 7.0 days, p = 0.001), RSV (9.0 days vs. 8.0 days, p = 0.016) infection alone group. Pneumonia was more common in the HBoV coinfection with RSV group compared with the HBoV, RSV infection alone group, respectively (75.0% vs. 44.2%, 31.3%, p < 0.001). HBoV DNA copy numbers (383 000 copies/ml) were positively correlated with the length of hospitalization (r = 0.334, p < 0.001).

Conclusion
HBoV coinfection with RSV increases HBoV infection severity.
Medical Student Suicide Rates: A Systematic Review of the Historical and International Literature
Authors: Blacker Caren J. , Lewis Charles P. , Swintak Cosima C. , Bostwick J. Michael , Rackley Sandra J. 
Published: August 2018

Purpose
Physician suicide rates are reportedly higher than those of the general population, but medical student suicide rates are not well studied. It is difficult to determine whether physician suicide rates can be predicted by medical student risk factors for suicide and difficult to identify those risk factors without knowing medical student suicide rates. The authors systematically reviewed the literature to collate data on medical student suicide rates.

Method
The authors searched the PubMed, Web of Science, and Library of Congress databases for papers published in any language before November 11, 2017. They identified 3,429 papers; after the initial screening process, they assessed 82 full-text articles for eligibility. Twelve ultimately met the full inclusion criteria; meta-analysis was not possible. Data regarding medical student suicide numbers and rates were extracted and compared with contemporaneous general population suicide rates using public epidemiological data, when available.

Results
Medical student suicide rates were infrequently reported in the historical and international literature, and data collection techniques were inconsistent. Generally, U.S. medical student suicide rates were lower than those of the contemporaneous general population. Proportionate mortality of medical students (number of deaths by a particular cause such as suicide divided by total number of deaths) was not reported in the literature.

Conclusions
Gaps exist in knowledge of medical student suicide rates, risk factors, and targets for intervention. Significant barriers have impeded information collection. Yet, more comprehensive data collection is needed to understand suicide risk in this population and to implement and improve effective intervention strategies.