bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data-Driven Design of Control Strategies for Distributed Energy Systems
Authors: Odonkor Philip , Lewis Kemper 
Published: June 2019

Abstract
The flexibility afforded by distributed energy resources in terms of energy generation and storage has the potential to disrupt the way we currently access and manage electricity. But as the energy grid moves to fully embrace this technology, grid designers and operators are having to come to terms with managing its adverse effects, exhibited through electricity price volatility, caused in part by the intermittency of renewable energy. With this concern however comes interest in exploiting this price volatility using arbitrage—the buying and selling of electricity to profit from a price imbalance—for energy cost savings for consumers. To this end, this paper aims to maximize arbitrage value through the data-driven design of optimal operational strategies for distributed energy resources (DERs). Formulated as an arbitrage maximization problem using design optimization principles and solved using reinforcement learning, the proposed approach is applied toward shared DERs within multi-building residential clusters. We demonstrate its feasibility across three unique building clusters, observing notable energy cost reductions over baseline values. This highlights a capability for generalized learning across multiple building clusters and the ability to design efficient arbitrage policies for energy cost minimization. The scalability of this approach is studied using two test cases, with results demonstrating an ability to scale with relatively minimal additional computational cost, and an ability to leverage system flexibility toward cost savings.
Monopodal Postural Stability Assessment by Wireless Inertial Measurement Units Through the Fast Fourier Transform
Authors: Pino-Ortega José , Hernández-Belmonte Alejandro , Gómez-Carmona Carlos D. , Bastida-Castillo Alejandro , García-Rubio Javier , Ibáñez Sergio J. 
Published: June 2019

Objectives: (1) To describe the fast Fourier transform (FFT) multijoint as monopodal postural stability measurement in well-trained athletes, (2) to compare the within-subject FFT between laterality, joints, and body segments, and (3) to establish the within- and between-subject relationship between joints. Methods: Twelve national-level basketball players participated voluntarily in this investigation. The participants performed two 60-second repetitions of a monopodal stability test (1 repetition with each lower limb), separated by 3 minutes of active recovery. All tests were recorded by 4 WIMU PRO™ inertial devices located on the ankle, knee, lumbar spine, and thoracic spine. The main variable was total acceleration, where the FFT was applied. Results: The higher instability results were found in the ankle and in the nondominant lower limb (dominant = 1.131 [0.122] a.u. (arbitrary units); nondominant = 1.141 [0.172] a.u). In the body segment analysis, the greater percentage of differences (%diff) were shown between lumbar spine and knee in the dominant (%diff = −2.989%; d = 0.87) and nondominant (%diff = −3.243%; d = 0.90) lower limb. Finally, very large between-subjects variability was found in all joints and body segments. Conclusions: The described protocol is proposed for monopodal postural stability assessment, being useful to provide information about the stability of joints and the body segment between joints. Besides, a within-subject analysis is recommended, and the FFT calculation will enable a linear analysis of each test.
Is an Elastic Ankle Support Effective in Improving Jump Landing Performance, and Static and Dynamic Balance in Young Adults With and Without Chronic Ankle Instability?
Authors: John Cornelius , Stotz Andreas , Gmachowski Julian , Rahlf Anna Lina , Hamacher Daniel , Hollander Karsten , Zech Astrid 
Published: June 2019

Context: In some patients, ankle sprains lead to chronic symptoms like pain or muscular weakness called chronic ankle instability (CAI). External ankle supports have shown to be effective in preventing sprains and reducing recurrence, but the underlying mechanisms are unclear. As sensorimotor variables are associated with injury incidence, an influence of external ankle support on landing performance and balance seems plausible. Objective: To analyze the effects of an elastic ankle support on jump landing performance and static and dynamic balance in patients with CAI and healthy controls. Design: Crossover study. Setting: Functional tests in a laboratory setting. Patients or Other Participants: Twenty healthy students and 20 patients with CAI were included for study participation based on their scores in ankle stability and function questionnaires. Intervention: Healthy and CAI participants performed each test with and without an elastic ankle support. Main Outcome Measures: (1) Jump landing performance was measured with the Landing Error Scoring System, (2) static balance was assessed with the Balance Error Scoring System, and (3) dynamic balance was assessed using the Y Balance Test. Linear mixed models were used to analyze the effects of the elastic ankle support on sensorimotor parameters. Results: Healthy controls performed significantly better in the Landing Error Scoring System (P = .01) and Y Balance Test anterior direction (P = .01). No significant effects of elastic ankle support on Landing Error Scoring System, Balance Error Scoring System, or Y Balance Test performance were observed in the CAI or control group. There were no significant group-by-ankle support interactions. Conclusions: In the current study, the acute use of elastic ankle support was ineffective for enhancing jump landing performance, and static and dynamic balance. Further research is needed to identify the underlying mechanisms of the preventive effects of elastic ankle support.
Clot permeability and histopathology: is a clot’s perviousness on CT imaging correlated with its histologic composition?
Authors: Benson John Charles , Fitzgerald Sean T , Kadirvel Ramanathan , Johnson Collin , Dai Daying , Karen Doyle , Kallmes David F , Brinjikji Waleed 
Published: June 2019

BackgroundClot perviousness in large vessel occlusion has been shown to be associated with improved recanalization outcomes with mechanical thrombectomy and intravenous thrombolysis.ObjectiveTo evaluate the association between clot perviousness based on thrombus attenuation increase (TAI) on CT, and histologic composition of clots in acute ischemic stroke (AIS).MethodsA retrospective review was completed of patients with AIS secondary to large vessel occlusion, non-contrast CT (NCCT) and CT angiography (CTA) images, and histologic analysis of the retrieved clot. TAI was measured by subtracting clot attenuation on NCCT from the attenuation on CTA. Up to 3 regions of interest (ROIs) were evaluated on each clot; the average attenuation was used for analysis if multiple ROIs were assessed. Pervious clots were defined as TAI ≥10 Hounsfield units (HUs); impervious clots had TAI <10 HU. Histopathologic analyses of clots were assessed for relative compositions of red blood cells (RBCs), white blood cells (WBCs), fibrin, and platelets/other.Results57 patients were included. Pervious clots were more likely to be RBC rich (p=0.04); impervious clots were more likely to be fibrin and WBC rich (p=0.01 for both). Pervious clots also had greater RBC density than impervious clots (49.8% and 33.0%, respectively; p=0.006); fibrin density of pervious clots was lower than that of impervious clots (17.8% and 23.2%, respectively; p=0.02).ConclusionClot perviousness, assessed on NCCT and CTA imaging, is associated with higher RBC density and lower fibrin density, offering a possible explanation for the higher rates of successful thrombectomy and favorable clinical outcome seen in such patients.
A high-salt meal does not augment blood pressure responses during maximal exercise
Authors: Migdal Kamila U. , Robinson Austin T. , Watso Joseph C. , Babcock Matthew C. , Serrador Jorge M. , Farquhar William B. 
Published: June 2019

Augmented blood pressure (BP) responses during exercise are predictive of future cardiovascular disease. High dietary sodium (Na+) increases BP responses during static exercise. It remains unclear if high dietary Na+ augments BP responses during dynamic exercise. The purpose of this study was to test the hypothesis that an acute high-Na+ meal would augment BP responses during dynamic exercise. Twenty adults (10 male/10 female; age, 26 ± 5 years; BP, 105 ± 10/57 ± 6 mm Hg) were given a high-Na+ meal (HSM; 1495 mg Na+) and a low-Na+ meal (LSM; 138 mg Na+) separated by at least 1 week, in random order. Serum Na+ and plasma osmolality were measured. Eighty minutes following the meal, participants completed a graded-maximal exercise protocol on a cycle ergometer. Heart rate, beat-by-beat BP, cardiac output, total peripheral resistance, and manual BP were measured at rest and during exercise. Both serum Na+ (HSM: Δ1.6 ± 2.0 vs LSM: Δ1.1 ± 1.8 mmol/L, P = 0.0002) and plasma osmolality (HSM: Δ3.0 ± 4.5 vs LSM: Δ2.0 ± 4.2 mOsm/(kg·H2O), P = 0.01) were higher following the HSM. However, the HSM did not augment BP during peak exercise (systolic BP: HSM: 170 ± 23 vs LSM: 171 ± 21 mm Hg, P = 0.81). These findings suggest that an acute high-salt meal does not augment BP responses during dynamic exercise in adults. Novelty The high-salt meal increased serum sodium and plasma osmolality compared with the low-salt meal. The high-salt meal did not augment blood pressure responses during maximal dynamic exercise. This is important as augmented blood pressure responses during exercise put individuals at greater risk for development of cardiovascular disease.
A Build System for Software Development in Robotic Academic Collaborative Environments
Authors: Domenichelli Daniele E. , Traversaro Silvio , Muratore Luca , Rocchi Alessio , Nori Francesco , Natale Lorenzo 
Published: June 2019

The software development cycle in the robotic research environment is hectic and heavily driven by project or paper deadlines. Developers have only little time available for packaging the C/C++ code they write, develop and maintain the build system and continuous integration tools. Research projects are joint efforts of different groups working remotely and asynchronously. The typical solution is to rely on binary distributions and/or large repositories that compile all software and dependencies. This approach hinders code sharing and reuse and often leads to repositories whose inter-dependencies are difficult to manage. Following many years of experience leading software integration in research projects, we developed YCM, a tool that supports our best practices addressing these issues. YCM is a set of CMake scripts that provides (1) build system support: to develop and package software libraries and components, and (2) superbuild deployment: to prepare and distribute sets of packages in source form as a single meta build. In this paper, we describe YCM and report on our experience adopting it as a tool for managing software repositories in large research projects.
Comparison of TwoGinkgo bilobaL. Extracts on Oxidative Stress and Inflammation Markers in Human Endothelial Cells
Authors: Piazza Stefano , Pacchetti Barbara , Fumagalli Marco , Bonacina Fabrizia , Dell’Agli Mario , Sangiovanni Enrico 
Published: June 2019

Atherosclerosis is characterized by interaction between immune and vascular endothelial cells which is mediated by adhesion molecules occurring on the surface of the vascular endothelium leading to massive release of proinflammatory mediators.Ginkgo bilobaL.(Ginkgoaceae) standardized extracts showing beneficial effects are commonly prepared by solvent extraction, and acetone is used according to the European Pharmacopoeia recommendations; the well-knownGinkgo bilobaacetone extract EGb761® is the most clinically investigated. However, in some countries, the allowed amount of solvent is limited to ethanol, thus implying that the usage of a standardizedGinkgo bilobaethanol extract may be preferred in all those cases, such as for food supplements. The present paper investigates if ethanol and acetone extracts, with comparable standardization, may be considered comparable in terms of biological activity, focusing on the radical scavenging and anti-inflammatory activities. Both the extracts showed high inhibition of TNFα-induced VCAM-1 release (41.1-43.9 μg/mL), which was partly due to the NF-κB pathway impairment. Besides ROS decrease, cAMP increase following treatment with ginkgo extracts was addressed and proposed as further molecular mechanism responsible for the inhibition of endothelial E-selectin. No statistical difference was observed between the extracts. The present study demonstrates for the first time that ethanol and acetone extracts show comparable biological activities in human endothelial cell, thus providing new insights into the usage of ethanol extracts in those countries where restrictions in amount of acetone are present.
Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling
Authors: D'Agostino Luca , Nie Yingchao , Goswami Sayantani , Tong Kevin , Yu Shiyan , Bandyopadhyay Sheila , Flores Juan , Zhang Xiao , Balasubramanian Iyshwarya , Joseph Ivor , Sakamori Ryotaro , Farrell Victoria , Li Qi , Yang Chung S. , Gao Bin , Ferraris Ronaldo P. , Yehia Ghassan , Bonder Edward M. , Goldenring James R. , Verzi Michael P. , Zhang Lanjing , Ip Y. Tony , Gao Nan 
Published: June 2019

AbstractThe effects of polarized membrane trafficking in mature epithelial tissue on cell growth and cancer progression have not been fully explored in vivo. A majority of colorectal cancers have reduced and mislocalized Rab11, a small GTPase dedicated to trafficking of recycling endosomes. Patients with low Rab11 protein expression have poor survival rates. Using genetic models across species, we show that intact recycling endosome function restrains aberrant epithelial growth elicited by APC or RAS mutations. Loss of Rab11 protein led to epithelial dysplasia in early animal development and synergized with oncogenic pathways to accelerate tumor progression initiated by carcinogen, genetic mutation, or aging. Transcriptomic analysis uncovered an immediate expansion of the intestinal stem cell pool along with cell-autonomous Yki/Yap activation following disruption of Rab11a-mediated recycling endosomes. Intestinal tumors lacking Rab11a traffic exhibited marked elevation of nuclear Yap, upd3/IL6-Stat3, and amphiregulin-MAPK signaling, whereas suppression of Yki/Yap or upd3/IL6 reduced gut epithelial dysplasia and hyperplasia. Examination of Rab11a function in enteroids or cultured cell lines suggested that this endosome unit is required for suppression of the Yap pathway by Hippo kinases. Thus, recycling endosomes in mature epithelia constitute key tumor suppressors, loss of which accelerates carcinogenesis.Significance:Recycling endosome traffic in mature epithelia constitutes a novel tumor suppressing mechanism.
A new generic name for the Cuban Bare-legged Owl Gymnoglaux lawrencii Sclater and Salvin
Authors: OLSON STORRS L. , SUÁREZ WILLIAM 
Published: June 2019

The two species of Antillean "screech" owls, notable for having unfeathered tarsi and lacking erectile "ear" tufts, have a rather complicated early history because specimens were at first very rare in collections so that for a long time no investigator was able to compare the two side by side. The first to be described was Strix nudipes Daudin (1800), now known as the Puerto Rican Screech-Owl Otus nudipes (American Ornithologists' Union [AOU] 1983, 1998). Bonaparte (1854) proposed the monotypic genus Gymnasio for the Puerto Rican bird with Strix nudipes Daudin as the type.
Sensitivity of Simulated GMI Brightness Temperatures to Variations in Particle Size Distributions in a Severe Hailstorm
Authors: Leppert II Kenneth D. , Cecil Daniel J. 
Published: June 2019

AbstractGlobal Precipitation Measurement (GPM) Microwave Imager (GMI) brightness temperatures (BTs) were simulated over a case of severe convection in Texas using ground-based S-band radar and the Atmospheric Radiative Transfer Simulator. The median particle diameter Do of a normalized gamma distribution was varied for different hydrometeor types under the constraint of fixed radar reflectivity to better understand how simulated GMI BTs respond to changing particle size distribution parameters. In addition, simulations were conducted to assess how low BTs may be expected to reach from realistic (although extreme) particle sizes or concentrations. Results indicate that increasing Do for cloud ice, graupel, and/or hail leads to warmer BTs (i.e., weaker scattering signature) at various frequencies. Channels at 166.0 and 183.31 ± 7 GHz are most sensitive to changing Do of cloud ice, channels at ≥89.0 GHz are most sensitive to changing Do of graupel, and at 18.7 and 36.5 GHz they show the greatest sensitivity to hail Do. Simulations contrasting BTs above high concentrations of small (0.5-cm diameter) and low concentrations of large (20-cm diameter) hailstones distributed evenly across a satellite pixel showed much greater scattering using the higher concentration of smaller hailstones with BTs as low as ~110, ~33, ~22, ~46, ~100, and ~106 K at 10.65, 18.7, 36.5, 89.0, 166.0, and 183.31 ± 7 GHz, respectively. These results suggest that number concentration is more important for scattering than particle size given a constant S-band radar reflectivity.
Systematic review: Do commercial tourniquets have potential to be a life-saving intervention for ambulance services?
Authors: Wongtongkam Nualnong 
Published: June 2019

Background:Globally, terrorist attacks have major impact because of high rates of mortality and severe injury. Compression with direct pressure may be time-consuming in limb exsanguination and accelerate onset of haemorrhagic shock. Tourniquet applications have undergone scrutiny over a long period, but recently tourniquets have been developed and modified for effective and efficient use in prehospital settings to mitigate adverse effects.Objectives:This systematic review aimed at examining commercial tourniquets that demonstrated efficacy for use in prehospital services.Methods:Six search engines (ScienceDirect, Ovid, PubMed, SAGE, SpringerLink, Taylor & Francis) were used and articles of which 14 were selected for data analysis.Results:The findings were not sufficiently conclusive to pinpoint whether one tourniquet application was superior overall; however, Combat Application Tourniquet appeared to be better than other commercial tourniquets in terms of occlusion of distal blood flow, easy and quick self-application and fewer complications.Conclusion:In prehospital settings, ambulance personnel should not hesitate to apply tourniquets when encountering critical circumstances in which they must choose between saving life and potential complications.
1,25-Dihydroxyvitamin D Maintains Brush Border Membrane NaPi2a and Attenuates Phosphaturia in Hyp Mice
Authors: Martins Janaina S , Liu Eva S , Sneddon W Bruce , Friedman Peter A , Demay Marie B 
Published: June 2019

AbstractPhosphate homeostasis is critical for many cellular processes and is tightly regulated. The sodium-dependent phosphate cotransporter, NaPi2a, is the major regulator of urinary phosphate reabsorption in the renal proximal tubule. Its activity is dependent upon its brush border localization that is regulated by fibroblast growth factor 23 (FGF23) and PTH. High levels of FGF23, as are seen in the Hyp mouse model of human X-linked hypophosphatemia, lead to renal phosphate wasting. Long-term treatment of Hyp mice with 1,25-dihydroxyvitamin D (1,25D) or 1,25D analogues has been shown to improve renal phosphate wasting in the setting of increased FGF23 mRNA expression. Studies were undertaken to define the cellular and molecular basis for this apparent FGF23 resistance. 1,25D increased FGF23 protein levels in the cortical bone and circulation of Hyp mice but did not impair FGF23 cleavage. 1,25D attenuated urinary phosphate wasting as early as one hour postadministration, without suppressing FGF23 receptor/coreceptor expression. Although 1,25D treatment induced expression of early growth response 1, an early FGF23 responsive gene required for its phosphaturic effects, it paradoxically enhanced renal phosphate reabsorption and NaPi2a protein expression in renal brush border membranes (BBMs) within one hour. The Na-H+ exchange regulatory factor 1 (NHERF1) is a scaffolding protein thought to anchor NaPi2a to the BBM. Although 1,25D did not alter NHERF1 protein levels acutely, it enhanced NHERF1-NaPi2a interactions in Hyp mice. 1,25D also prevented the decrease in NHERF1/NaPi2a interactions in PTH-treated wild-type mice. Thus, these investigations identify a novel role for 1,25D in the hormonal regulation of renal phosphate handling.
Association Between Urinary Triclosan With Bone Mass Density and Osteoporosis in US Adult Women, 2005‒2010
Authors: Cai Shaofang , Zhu Jiahao , Sun Lingling , Fan Chunhong , Zhong Yaohong , Shen Qing , Li Yingjun 
Published: June 2019

Abstract

Context
Laboratory studies have demonstrated that triclosan (TCS) can cause significant interstitial collagen accumulation and an increase in trabecular bone. However, little is known about the relationship between TCS exposure and human bone health.

Methods
We used 2005 to 2010 National Health and Nutrition Examination Survey data to examine the association between urinary TCS concentration and bone mineral density (BMD) and osteoporosis in US adult women aged ≥20 years. After inclusion and exclusion, 1848 women were analyzed.

Results
After adjustment for other covariates, we observed significant associations between tertile 3 of TCS concentration and lower BMD in regions of the total femur (β = −0.016; 95% CI = −0.032, −0.000), intertrochanteric region (β = −0.022; 95% CI = −0.042, −0.002), and lumbar spine (β = −0.014; 95% CI = −0.029, 0.001), respectively, relative to tertile 1. Compared with women at tertile 1, those at tertile 3 were more likely to have increased prevalence of osteoporosis in the intertrochanteric region (OR = 2.464; 95% CI = 1.190, 5.105).

Conclusion
This epidemiological study investigated the association between urinary TCS concentration and BMD and osteoporosis in US adult women. We found urinary TCS concentration was negatively associated with BMD and was positively associated with the prevalence of osteoporosis. The evidence was stronger in postmenopausal women than in premenopausal women. Future prospective studies are needed to validate these findings.
The Effect of In Vitro Hemolysis on Measurement of Cell-Free DNA
Authors: Nishimura Fumitaka , Uno Naoki , Chiang Ping-Chia , Kaku Norihito , Morinaga Yoshitomo , Hasegawa Hiroo , Yanagihara Katsunori 
Published: June 2019

Abstract

Background
Hemolysis during blood drawing is a common cause of laboratory artifacts. Although circulating cell-free tumor DNA and fetal DNA are currently measured in routine practice, the effect of in vitro hemolysis on the measurement of cell-free DNA (cfDNA) has not been investigated. When in vitro hemolysis occurs, cellular DNA could be released from damaged white blood cells and reduce the fraction of circulating tumor DNA and fetal DNA.

Methods
Blood from healthy individuals was collected and passed through a narrow needle to cause in vitro hemolysis. Plasma was separated before and after mechanical damage, and concentrations of free hemoglobin and cfDNA of 2 reference genes were measured.

Results
cfDNA of 2 reference genes and free hemoglobin increased after mechanical damage. A clear correlation between cfDNA and free hemoglobin was observed.

Conclusion
cfDNA concentrations are higher in hemolyzed plasma. Therefore, the fraction of circulating tumor DNA and fetal DNA can be underestimated in plasma hemolyzed by inappropriate blood collection techniques.