bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterisation of a human antibody that potentially links cytomegalovirus infection with systemic lupus erythematosus
Authors: Neo Jie Ying Jacklyn , Wee Seng Yin Kelly , Bonne Isabelle , Tay Sen Hee , Raida Manfred , Jovanovic Vojislav , Fairhurst Anna-Marie , Lu Jinhua , Hanson Brendon J. , MacAry Paul A. 
Published: July 2019

AbstractHuman cytomegalovirus (HCMV) is a ubiquitous herpesvirus that has been linked with the development of systemic lupus erythematosus (SLE). Thus far, molecular mimicry has been implicated as the principal mechanism that explains this association. In this study, we characterise a potential alternative process whereby HCMV contributes to SLE. In a cohort of SLE patients, we show a significant association between HCMV infection and SLE through a human antibody response that targets UL44. UL44 is an obligate nuclear-resident, non-structural viral protein vital for HCMV DNA replication. The intracellular nature of this viral protein complicates its targeting by the humoral response – the mechanism remains unresolved. To characterise this response, we present a thorough molecular analysis of the first human monoclonal antibody specific for UL44 derived from a HCMV seropositive donor. This human antibody immunoprecipitates UL44 from HCMV-infected cells together with known nuclear-resident SLE autoantigens – namely, nucleolin, dsDNA and ku70. We also show that UL44 is redistributed to the cell surface during virus-induced apoptosis as part of a complex with these autoantigens. This phenomenon represents a potential mechanism for the bystander presentation of SLE autoantigens to the humoral arm of our immune system under circumstances that favour a break in peripheral tolerance.
Improving the management procedures in farms infected with the Porcine Reproductive and Respiratory Syndrome virus using PDP models
Authors: Colomer Ma Àngels , Margalida Antoni , Fraile Lorenzo 
Published: July 2019

AbstractPig meat production need to be built up in the future due to the increase of the human population worldwide. To address this challenge, there is plenty of room for improvement in terms of pig production efficiency that could be severely hampered by the presence of diseases. In this sense, Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is one of the most costly disease present in industrial pork production in Europe and North America. We have developed a model to analyze the effect of different management procedures to control this important virus in different epidemiological scenarios. Our results clearly suggest that no cross-fostering during lactation and the maintaining of litter integrity significantly decrease the number of sick and dead animals during the rearing period compared to scenarios where cross-fostering and no litter integrity are practiced. These results highlight the relevance of different management strategies to control PRRSV and quantify the effect of limiting cross-fostering and avoiding mixing animals from different litters in PRRSV positive farms to optimize animal production. Our findings will allow pig farmers to apply these management procedures to control this disease under field conditions in a very cost-effective way.
Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor
Authors: Zhang Cunyu , Creech Katrina L. , Zuercher William J. , Willson Timothy M. 
Published: July 2019

AbstractDevelopment of an efficient and scalable synthesis of 6-formylindolo[3,2-b]carbazole (FICZ), a naturally-occurring aryl hydrocarbon receptor (AhR) ligand, allowed its biological and physical properties to be studied. FICZ was shown to be the most potent among a series of 6-substituted indolo[3,2-b]carbazoles for activation of AhR in cells. Photostability studies of FICZ revealed a non-enzymatic mechanism for its conversion to a biologically active quinone. These results further support the hypothesis that FICZ is a light-dependent hormone that links sun exposure to regulation of biological pathways in peripheral tissues.
Bypassed and Preserved Stomach Resulted in Superior Glucose Control in Sprague-Dawley Rats with Streptozotocin-Induced Diabetes
Authors: Widjaja Jason , Dolo Ponnie Robertlee , Zhang Qiang , Yao Libin , Li Chao , Hong Jian , Wang Hui , Meng Song , Shao Yong , Zhu Xiaocheng 
Published: July 2019

AbstractRecent studies suggest the possibility of the stomach playing a role in diabetes remission after bariatric surgery. In this study, we investigated whether bypassing the stomach alleviates diabetes in diabetic rodent model. Eighteen moderately obese and diabetic Sprague-Dawley rats were randomly assigned to Esophagoduodenostomy with or without gastric preservation (EDG and EDNG/total gastrectomy, respectively), and SHAM groups. Bodyweight, food intake, fasting glucose level, oral glucose tolerance test result (OGTT), and hormone levels (insulin, glucagon-like peptide-1, ghrelin, gastrin and glucagon) were measured preoperative and postoperatively. Postoperatively, bodyweight and food intake did not differ significantly between the EDG and EDNG groups. Postoperative fasting blood glucose and OGTT results declined significantly in the EDG and EDNG group when compared with the respective preoperative levels. Postoperative glucose control improvements in EDNG group was significantly inferior when compared to EDG. Compared preoperatively, postoperative plasma ghrelin and gastrin levels declined significantly in EDNG group. Preoperative and postoperative plasma GLP-1 level did not differ significantly among all the groups. Postoperatively, EDG group had significantly higher insulin and lower glucagon levels when compared with SHAM. In conclusion, bypassing and preserving the stomach resulted in superior glucose control improvements than total gastrectomy.
Metabolic hormones and breast cancer risk among Mexican American Women in the Mano a Mano Cohort Study
Authors: Shen Jie , Hernandez Daphne , Ye Yuanqing , Wu Xifeng , Chow Wong-Ho , Zhao Hua 
Published: July 2019

AbstractC-peptide, insulin, leptin, and other metabolic hormones are assumed to play roles in breast cancer development; though, results are inconsistent. In this prospective case-control study nested within the Mano a Mano Cohort Study, we assessed the risk of breast cancer with regard to plasma levels of c-peptide, gastric inhibitory polypeptide, insulin, leptin, monocyte chemoattractant protein-1, pancreatic polypeptide, and peptide YY. Among women followed for a median of 8.5 years, 109 breast cancer cases were identified and frequency-matched to 327 controls at a ratio of 1:3. Overall, only c-peptide was observed significantly associated with breast cancer risk. High c-peptide levels (≥ the median level of controls) were significantly associated with increased breast cancer risk (odds ratio [OR] = 1.39, 95% confidence interval [CI]: 1.01, 2.44). In an analysis of participants stratified by age, the significant association between c-peptide levels and breast cancer risk was evident in only women age ≥51 years (OR = 1.53, 95% CI: 1.02, 3.27). Among women age <51 years, high leptin levels were significantly associated with decreased breast cancer risk (OR = 0.49, 95% CI: 0.24, 0.82). Our findings suggest that selected metabolic hormones are associated with breast cancer development in Mexican American women.
Effect of different shading materials on grain yield and quality of rice
Authors: Chen Hong , Li Qiu-Ping , Zeng Yu-Ling , Deng Fei , Ren Wan-Jun 
Published: July 2019

AbstractLight is a basic environmental factor required for plant growth and development; however, these are not only affected by light quantity, but also by light quality - light and radiation of different wavelengths and different compositions. In four different rice varieties (Oryza sativaL.), two kinds of shading materials, white cotton yarn (Shading (W)) and black nylon net (Shading (B)) were used to simulate cloudy days. Yield decreased under Shading (W) (15.3–17.7%) and Shading (B) (16.6–20.0%) compared to under sunny day (CK), and different effects on rice quality, which is mainly affected by changes in light quality, were observed. The change in light quality (Blue, Green, Red and R/FR proportions) represented under Shading (W) was significantly different from that under CK and Shading (B) conditions. Red light composition under Shading (W) was closer to that of the cloudy day condition. The proportion of blue light under Shading (W) was significantly lower than that under CK conditions; under Shading (B), it was higher than that under all conditions. The differences in light quality may affect photosynthesis in leaves and final starch synthesis, resulting in increased chalky grain rate, chalkiness, and poor rice quality. White cotton yarn as the shading material for further research used to simulate the influence of the light environment on rice growth under cloudy conditions will be better than black net.
Development of liver surface nodularity quantification program and its clinical application in nonalcoholic fatty liver disease
Authors: Kim Tae-Hoon , Kim Ji Eon , Ryu Jong-Hyun , Jeong Chang-Won 
Published: July 2019

AbstractThe liver morphological changes in relation to fibrosis stage in nonalcoholic fatty liver disease (NAFLD) have not yet been clearly understood. This study was to develop a liver surface nodularity (LSN) quantification program and to compare the fibrosis grades in simple steatosis (SS) and nonalcoholic steatohepatitis (NASH). Thirty subjects (7 normal controls [NC], 12 SS and 11 NASH) were studied. LSN quantification procedure was bias correction, boundary detection, segmentation and LSN measurement. LSN scores among three groups and fibrosis grades compared using Kruskal–Wallis H test. Diagnostic accuracy was determined by calculating the area under the receiver operating characteristics (ROC) curve. Mean LSN scores were NC 1.30 ± 0.09, SS 1.54 ± 0.21 and NASH 1.59 ± 0.23 (p = 0.008). Mean LSN scores according to fibrosis grade (F) were F0 1.30 ± 0.09, F1 1.45 ± 0.17 and F2&F3 1.67 ± 0.20 (p = 0.001). The mean LSN score in F2&F3 is significantly higher than that in F1 (p = 0.019). The AUROC curve to distinguish F1 and F2&F3 was 0.788 (95% CI 0.595–0.981, p = 0.019) at a cut-off LSN score greater than 1.48, and its diagnostic accuracy had 0.833 sensitivity and 0.727 specificity. This study developed LSN program and its clinical application demonstrated that the quantitative LSN scores can help to differentially diagnose fibrosis stage in NAFLD.
Thermophysical Fingerprinting of Probiotic-Based Products
Authors: Razafindralambo Hary , Razafindralambo Aurélie , Blecker Christophe 
Published: July 2019

AbstractVariability in efficacy and safety is a worldwide concern with commercial probiotics for their growing and inevitable use in food and health sectors. Here, we introduce a probiotic thermophysical fingerprinting methodology using a coupling thermogravimetry and differential scanning calorimetry. Qualitative and quantitative information on the material decomposition and transition phases is provided under heating conditions. By monitoring the changes in both mass and internal energy over temperature and time, a couple of thermal data at the maximum decomposition steps allow the creation of a unique and global product identity, depending on both strain and excipient components. We demonstrate that each powder formulation of monostrain and multistrain from different lots and origins have a unique thermophysical profile. Our approach also provides information on the formulation thermostability and additive/excipient composition. An original fingerprint form is proposed by converting the generated thermal data sequence into a star-like pattern for a perspective library construction.
Phonation Demonstrates Goal Dependence Under Unique Vocal Intensity and Aerobic Workload Conditions
Authors: Ziegler Aaron , VanSwearingen Jessie , Jakicic John M. , Verdolini Abbott Katherine 
Published: July 2019

Purpose
This study investigated whether metabolic respiratory requirements (treadmill workload) affected glottal valving in phonation, based on aerodynamic measures, when a sound pressure level (vocal SPL) is dictated as a target goal. Consistent with a theory of action, we hypothesized that adjustments in glottal valving as measured by laryngeal airway resistance would be dependent upon vocal SPL level, even as workload increased, and loud vocal SPL would interfere more with respiratory homeostasis than spontaneous vocal SPL.

Method
Thirty-two women enrolled who were ages 18–35 years. A repeated-measures design was used with random assignment of workload and vocal SPL conditions. Aerodynamic and acoustic data were collected during phonation, as were gas volume and concentration data. Analyses were performed with generalized estimating equations.

Results

Laryngeal airway resistance at a low workload significantly increased when vocal SPL changed from spontaneous to loud. At a loud vocal SPL, laryngeal airway resistance decreased when workload changed from rest to either low or high. Regarding the respiratory system response, minute ventilation increased at a loud vocal SPL when workload changed from rest to either low or high. End-tidal CO
2
increased under low and high workloads relative to rest at loud and spontaneous vocal SPLs.

Conclusions
Mostly consistent with a theory of action, in which motor control is goal dependent (i.e., vocal SPL targets), speakers can achieve a loud vocal SPL despite increases in workload requirements. In contrast, laryngeal airway resistance stays relatively low when vocal SPL occurs spontaneously, suggesting glottal adjustments are made to improve gas exchange as metabolic respiratory requirements become prioritized. Metabolic respiratory requirements appear to be overcome by the overlay of motor control for voicing when a loud vocal SPL is targeted. The implication of goal-dependent phonation for clinicians is that real-world conditions (i.e., loud vocal SPL) matter in vocal testing and voice therapy.
Homography‐based traffic sign localisation and pose estimation from image sequence
Authors: Cui Zhichao , Liu Yuehu , Ren Fuji 
Published: July 2019

This study proposes a vision‐based method for traffic sign attribute estimation, i.e. 3D position and pose, from image sequences by binocular or monocular cameras. The method starts with acquiring robust feature correspondences based on homography constraints from image pairs. Then the objective function is designed to integrate the feature correspondences to optimise the parameters of the traffic sign plane in the 3D coordinate. Finally, the sign plane is utilised for attribute estimation. In addition, the authors provide an extension for the raw KITTI dataset, which can be utilised for 3D tasks of traffic sign localisation and pose estimation. In the experiments, three popular methods are employed for comparisons based on the publicly available BelgiumTS and KITTI datasets. The results show that the authors’ method based on SIFT and SURF features can locate the traffic signs with a mean error of ∼0.44 and 0.51 m in the BelgiumTS and KITTI datasets, respectively, and estimate the pose with a mean error of ∼14.45° in the KITTI dataset.
One‐step solvothermal synthesis of Cu–Cu2 O composite with improved photocatalytic activity under visible light irradiation
Authors: Gao Hui , Hu Ya Wei , Xue Ying 
Published: July 2019

Microspheres‐like Cu–Cu2 O composites were successfully fabricated through a facial one‐step solvothermal method. The phase and morphology of Cu‐Cu2 O composites were characterised by X‐ray diffraction, scanning and transmission electron microscopy, and high‐resolution transmission electron microscopy. Also, the photodegradation experimental of methyl orange (MO) displayed that the as‐obtain Cu–Cu2 O composites possess excellent photocatalytic activity. After 120 min visible light irradiation, the photodegradation rate of MO on pure Cu2 O and Cu–Cu2 O was up to 11.8 and 90.6%, respectively. Moreover, the photodegradation rate of MO on Cu–Cu2 O was 19.5 times than that on pure Cu2 O. The great photocatalytic activity of Cu–Cu2 O composites might be ascribed to the appropriate amount of Cu, which could promote the transfer of photo‐generated electrons and restrain the recombination of electron–hole.
Die Steppenraute, Peganum harmala L. – eine alte Unbekannte
Authors: Baroud Bilal , Kermani Peyman , Melzig Matthias F. 
Published: July 2019

ZusammenfassungDie Steppenraute Peganum harmala L. ist eine Pflanze der Trockengebiete Zentralasiens bis in den Mittelmeerraum aus der Familie der Nitrariaceae. Besonders die Samen (Semen Harmalae) werden seit der Antike zu rituellen Zwecken als Halluzinogen und in der traditionellen Heilkunde verwendet. Inhaltsstoffe sind v. a. Indolalkaloide, wie β-Carboline und Chinazolinalkaloide mit ausgeprägten Wirkungen auf das ZNS und das Herz-Kreislauf-System. Trotz einer großen Anzahl von Berichten zu vielfältigen pharmakologischen Effekten besitzt die Droge gegenwärtig keine therapeutische Bedeutung.
Diced Cartilage bei Nasenkorrekturen
Authors: Völklein Claudia , Riechelmann Herbert 
Published: July 2019

ZusammenfassungEine ebenmäßig und ästhetisch modellierte Oberfläche des Nasenrückens und der
Nasenspitze ist das erwünschte Endergebnis septorhinoplastischer Eingriffe
sowohl für den Operateur als auch für den Patienten. Beim Einsatz von DC im
Rahmen der Septorhinoplastik und in den Variationen des DCF (Diced Cartilage
Framework) werden bevorzugt autologe Materialien mit hoher Biokompatibilität und
damit minimiertem Risiko für Infektionen und Abstoßung verwendet. Histologische
Untersuchungen postulieren für den DC und das DCF ein regeneratives Potenzial
mit Zugaben von PRF (Platelet rich Fibrin) aus dem eigenen Plasma des Patienten.
Die Herstellung des DC und des DCF aus autologem Knorpel ist leicht zu erlernen
und kann von der Operationsassistenz parallel zum Eingriff vorbereitet werden.
Die Zubereitung des PRF ist standardisiert. Form und Größe der
Diced-Cartilage-Grafts sind sehr variabel, ebenso wie der Ort der Applikation an
der Nase. Der geschnittene Knorpel kann frei unter die Haut appliziert werden
oder als DCF mit autologer Faszie, Perichondrium und aPRF (Advanced Platelet
rich Fibrin) Clot umhüllt werden. Der DCF-Graft kann einige Tage nach dem
Einsetzen noch nachmodelliert werden. Es sollte keine Überkorrektur erfolgen,
denn der Graft verbleibt in der Masse konstant und wird nicht resorbiert. DC und
DCF-Grafts sind nicht strukturverbessernd und nur zur Modellierung der Kontur
geeignet, sie können als ergänzende Komponente nach einem strukturverbessernden
Aufbau der inneren Stützstrukturen der Nase eingesetzt werden. Die Anpassung und
Anwendung des DC und des DCF erfolgt somit immer zum Ende der
septorhinoplastischen Operation. Die einfache Anwendung und die Flexibilität
dieser Technik mit dem Ziel eines modellierbaren, sich schnell in die Kontur des
Nasenrückens integrierenden Graft überzeugen sowohl bei FDC (freiem DC) als auch
beim DCF. Sie können zur routinemäßigen Anwendung für die Modellierung der
Kontur bei einer Septorhinoplastik empfohlen werden.
Therapeutische Allianz und Rehabilitationszufriedenheit von Menschen mit Migrationshintergrund in der psychosomatischen Rehabilitation – Analyse routinemäßig erhobener Daten
Authors: Kessemeier Franziska Maria , Bassler Markus , Petermann Franz , Kobelt-Pönicke Axel 
Published: July 2019

Zusammenfassung
Ziel der Studie Die therapeutische Allianz ist ein wichtiger Wirkfaktor in der psychotherapeutischen Behandlung. Der Zusammenhang von Rehabilitationszufriedenheit und therapeutischer Allianz ist gut belegt. Arbeiten zum Einfluss des Migrationshintergrundes stehen aus. Untersucht wird, ob der Migrationsstatus Einfluss auf die therapeutische Allianz und die Rehabilitationszufriedenheit von PatientInnen der psychosomatischen Rehabilitation hat.
Methodik Zunächst werden PatientInnen mit und ohne Migrationshintergrund hinsichtlich soziodemografischer Variablen und der Symptomschwere verglichen. Die gefundenen Unterschiede werden in einem Propensity Score Matching berücksichtigt. Die Patientengruppen werden vor und nach dem Matching mittels Varianzanalyse auf Unterschiede hinsichtlich ihrer Reha-Zufriedenheit und therapeutischen Allianz analysiert.
Ergebnisse PatientInnen mit Migrationshintergrund waren häufiger weiblich, hatten ein niedrigeres Bildungsniveau und berichteten eine stärkere Symptomschwere. PatientInnen mit Migrationshintergrund bewerteten sowohl die Rehabilitationszufriedenheit als auch die therapeutische Allianz negativer. Die gefundenen Effekte waren jedoch sehr klein und konnten nach dem Matching nicht repliziert werden.
Schlussfolgerungen Die negativere Bewertung der Rehabilitationszufriedenheit und der therapeutischen Allianz durch PatientInnen mit Migrationshintergrund ist auf ihre problematischere soziodemografische und psychosomatische Ausgangslage zurückzuführen. Werden diese Merkmale konstant gehalten, werden keine Unterschiede zwischen den Patientengruppen gefunden. Der hohe Zusammenhang von therapeutischer Allianz und Rehabilitationszufriedenheit unterstreicht die Bedeutung der therapeutischen Allianz für eine gelingende psychosomatische Rehabilitation.
Is There a Relationship Between Vitamin D Deficiency Status and PCOS in Infertile Women?
Authors: Arslan Emine , Gorkem Umit , Togrul Cihan 
Published: July 2019

Abstract
Introduction It is still unclear in the literature whether low vitamin D levels play a role in the pathogenesis of polycystic ovary syndrome (PCOS), especially with respect to the regulation of anti-Müllerian hormone (AMH). Therefore, we aimed to investigate whether there could be a relationship between vitamin D deficiency status and PCOS.
Materials and Methods A total of 146 infertile women were divided into two groups according to their ovarian reserve patterns: (i) normal (NOR), and (ii) high (PCOS). The participants were also categorized into two groups according to vitamin D concentrations: (i) Group A < 10 ng/mL, and (ii) Group B 10 – 20 ng/mL. Samples were obtained and analyzed for estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), 17-hydroxyprogesterone (17-OHP), dehydroepiandrosterone sulfate (DHEA-S) and AMH.
Results In the NOR group, there were significant differences between Group A and Group B in terms of anthropometric characteristics (p < 0.05, for all). The women in both Group A and Group B had similar AMH concentrations (p > 0.005). Only the NOR group showed a significant though moderate negative correlation between 25(OH)D levels and anthropometric parameters. AMH levels were not correlated with 25(OH)D levels in the NOR or the PCOS group (r = − 0.112, p = 0.008; r = 0.027, p = 0.836). Multivariate regression analysis showed no impact of 25(OH)D on other study parameters. Only AMH measurements were significant enough (p < 0.001) to differentiate between PCOS and NOR patterns.
Conclusion We found no difference in serum 25(OH)D and AMH levels between women with and women without PCOS. No correlation could be demonstrated between 25(OH)D and AMH in the PCOS group or controls.