bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased surfactant protein‐D levels in the airways of preterm neonates with sepsis indicated responses to infectious challenges
Authors: Mackay Rose‐Marie A. , Townsend J. Paul , Calvert Jennifer , Anthony Mark , Wilkinson Andrew R. , Postle Anthony D. , Clark Howard W. , Todd David A. 
Published: October 2018

AbstractAimSepsis is multifactorial and potentially devastating for preterm neonates. Changes in surfactant protein‐D (SP‐D), phosphatidylcholine (PC) and PC molecular species during infection may indicate innate immunity or inflammation during sepsis. We aimed to compare these important pulmonary molecules in ventilated neonates without or with sepsis.MethodsEndotracheal aspirates were collected from preterm neonates born at 23–35 weeks and admitted to the neonatal intensive care unit at the John Radcliffe Hospital, Oxford, UK, from October 2000 to March 2002. Samples were collected at one day to 30 days and analysed for SP‐D, total PC and PC molecular species concentrations using enzyme‐linked immunosorbent assay and mass spectrometry.ResultsWe found that 8/54 (14.8%) neonates developed sepsis. SP‐D (p < 0.0001), mono‐ and di‐unsaturated PC were significantly increased (p = 0.05), and polyunsaturated PC was significantly decreased (p < 0.01) during sepsis compared to controls. SP‐D:PC ratios were significantly increased during sepsis (p < 0.001), and SP‐D concentrations were directly related to gestational age in neonates with sepsis (r2 = 0.389, p < 0.01).ConclusionIncreased SP‐D levels and changes in PC molecular species during sepsis were consistent with direct or indirect pulmonary inflammatory processes. Very preterm neonates we able to mount an acute inflammatory innate immune response to infectious challenges, despite low levels of surfactant proteins at birth.
Editorial: hepatitis B, fatty liver, and metabolic syndrome—interaction or co‐existence?
Authors: Kumar Rajneesh , Tan Chee‐Kiat 
Published: October 2018

Linked ContentThis article is linked to Kuo et al and Kuo and Lu papers. To view these articles visit https://doi.org/10.1111/apt.14960 and https://doi.org/10.1111/apt.14509.
Editorial: predicting recurrence of Crohn's disease after surgical resection—Close to a crystal ball. Authors’ reply
Authors: Allez Matthieu , Auzolle Claire , Le Bourhis Lionel , Seksik Philippe 
Published: October 2018

Linked ContentThis article is linked to Auzolle et al and Allez and Auzolle papers. To view these articles visit https://doi.org/10.1111/apt.14944 and https://doi.org/10.1111/apt.14978.
Editorial: which inflammatory bowel disease patients should be screened for Epstein‐Barr virus infection? Authors’ reply
Authors: de Francisco Ruth , Castaño‐García Andrés , Riestra Sabino 
Published: October 2018

Linked ContentThis article is linked to de Francisco et al and Hans and Scott papers. To view these articles visit https://doi.org/10.1111/apt.14933 and https://doi.org/10.1111/apt.14988.
Editorial: hepatitis B, fatty liver and metabolic syndrome—Interaction or co‐existence? Authors’ reply
Authors: Kuo Yuan‐Hung , Lu Sheng‐Nan 
Published: October 2018

Linked ContentThis article is linked to Kuo et al and Kumar and Tan papers. To view these articles visit https://doi.org/10.1111/apt.14960 and https://doi.org/10.1111/apt.14992.
Letter: association between proton pump inhibitors and the risk of hepatocellular carcinoma—authors’ reply
Authors: Shao Yu‐Hsuan Joni , Wu Szu‐Yuan 
Published: October 2018

Linked ContentThis article is linked to Shao et al and Ponzetto and Figura papers. To view these articles visit https://doi.org/10.1111/apt.14835 and https://doi.org/10.1111/apt.14970.
Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (CEQUEL)
Authors: Simon Judit , Geddes John R. , Gardiner Alexandra , Rendell Jennifer , Goodwin Guy M. , Mayer Susanne 
Published: October 2018

AbstractObjectivesAlthough not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its use.MethodsCost‐utility analysis of the CEQUEL trial comparing quetiapine plus lamotrigine vs quetiapine monotherapy (and folic acid vs placebo in an add‐on factorial design) for patients with bipolar depression (n = 201) from the health and social care perspective. Differences in costs together with quality‐adjusted life years (QALYs) between the groups were assessed over 52 weeks using a regression‐based approach.ResultsHealth‐related quality of life improved substantially for all randomization groups during follow‐up with no significant difference in QALYs between any of the comparisons (mean adjusted QALY difference: lamotrigine vs placebo −0.001 (95% CI: −0.05 to 0.05), folic acid vs placebo 0.002 (95% CI: −0.05 to 0.05)). While medication costs in the lamotrigine group were higher than in the placebo group (£647, P < 0.001), mental health community/outpatient costs were significantly lower (−£670, P < 0.001). Mean total costs were similar in the groups (−£180, P = 0.913).ConclusionsLamotrigine improved clinical ratings in bipolar depression compared with placebo. This differential effect was not detected using the EQ‐5D‐3L. The additional cost of lamotrigine was balanced by significant savings in some other medical costs which made its use cost neutral to the health service. Compared to placebo, folic acid produced neither clinical nor significant health economic benefits. The study supports the use of lamotrigine in combination with other drugs to treat bipolar depression.
Delphi survey of maintenance lithium treatment in older adults with bipolar disorder: An ISBD task force report
Authors: Shulman Kenneth I. , Almeida Osvaldo P. , Herrmann Nathan , Schaffer Ayal , Strejilevich Sergio A. , Paternoster Christina , Amodeo Sean , Dols Annemiek , Sajatovic Martha 
Published: October 2018

ObjectivesDespite the growing numbers and proportion of older adults with bipolar disorder (OABD), there are very limited guidelines for the use of lithium with its double‐edged potential for effectiveness and toxicity in this population. The primary aims of this Delphi survey were: (a) To determine the place of lithium among the preferred choices for maintenance treatment of OABD. (b) To provide detailed clinical guidelines for the safe and effective use of lithium in OABD.MethodsIn the face of limited evidence, the Delphi survey method was used to achieve consensus by a group of 25 experts in OABD from nine countries. An oversight committee monitored and analyzed the results of each survey and formulated more focused questions with each subsequent iteration.ResultsA 100% response rate was achieved for all three iterations of the survey. Lithium was the preferred choice for maintenance monotherapy in OABD. Serum levels of 0.4‐0.8 mmol/L were recommended for ages 60‐79 and serum levels of 0.4‐0.7 mmol/L were recommended for ages 80 and over. Specific recommendations achieved consensus for second line monotherapy as well as for other drugs to be used in combination with lithium if necessary. Guidelines for routine monitoring of lithium in OABD were provided for laboratory investigations and clinical assessments.ConclusionsLithium remains the preferred choice for maintenance monotherapy in OABD. Laboratories should report the therapeutic range for serum levels of lithium separately for older adults.
Significant predictors of mathematical literacy for top‐tiered countries/economies, Canada, and the United States on PISA 2012: Case for the sparse regression model
Authors: Brow Mark V. 
Published: October 2018

BackgroundNational ranking from the triennial Programme of International Student Assessment (PISA) often serves as a barometer of national performance and human capital. Though excessive student‐ and school‐level covariates (n > 700) may prove intractable for traditional least‐squares estimate procedures, shrinkage methods may be more suitable for subset selection.AimsWith a focus on the United States, this paper proposes sparse regression for PISA 2012 to discover salient student‐ and school‐level predictor variables for mathematical literacy achievement.SampleThe sparse regression analysis was conducted on 10 top‐tiered OECD countries/economies, Canada, and the United States in mathematical literacy on the 2012 PISA. Two‐ and three‐level hierarchical regression analyses were performed on Canadian and US students (N = 26,522) along with five of the ten top‐tiered countries/economies (N = 58,385).MethodsUsing the ‘least absolute shrinkage and selection operator’ (LASSO) technique, the study (1) identified salient predictor variables of mathematical literacy performance for the top‐tiered countries/economies, Canada, and the United States and (2) used these salient variables to perform two‐ and three‐level hierarchical regression on data from Canada and the United States along with five top‐tiered countries/economies. Weights and replicates were used to account for complex sample design. A weighted, two‐level confirmatory factor analysis was performed to identify latent constructs. Missing data were handled through multiple imputation.ResultsSeparate two‐level hierarchical models accounted for 32–35% student‐level and 58–70% school‐level variance in Canada and the United States, respectively; three‐level models accounted for 33% of level‐one variance, 62–65% level‐two variance, and 13–44% of level‐three variance for the US/Canada and US/Canada/top‐tiered students, respectively. Following top‐tiered countries/economies, Canadian students had high levels of self‐efficacy, were more likely to encounter advanced concepts in class, were less activity/small group‐centred, and were more likely to consider truancy a learning hindrance. Factor analyses revealed a positive relation with rigour and class organization (teacher‐centred) for top‐tiered countries and Canada, though not for the United States. For all countries, there was a strong relation between rigour and self‐beliefs.ConclusionCompared to top performers, a less rigorous curriculum, coupled with class and school factors, may explain lag in US performance.
Trait interpersonal vulnerability attenuates beneficial effects of constructive criticism on failure responses
Authors: Tortoriello Gregory K. , Hart William 
Published: October 2018

The extant literature on interpersonal criticism suggests that relative to destructive criticism, constructive criticism significantly minimizes the injurious psychological aftermath people experience after failure. However, we propose the possibility that for some people, these psychological benefits of constructive criticism are less apparent. Specifically, we hypothesized that for people high in trait interpersonal vulnerability, a construct marked by maladaptive cognitive‐emotional responses in interpersonal contexts and/or by dysfunctional relational concerns, effects of constructive (vs. destructive) criticism on reduced maladaptive appraisals will diminish, and this diminution of reduced maladaptive appraisals will predict downstream effects on worsened post‐failure mood. An experiment had a college sample (N = 349) complete four instruments represented under an interpersonal vulnerability construct (IVC). Next, participants imagined failing in various domains and receiving subsequent feedback from emotionally important others. Feedback type was manipulated to typify either destructive criticism or constructive criticism. Finally, participants provided ratings of maladaptive appraisals and post‐failure mood. Latent variable path modelling supported hypotheses. Effects of constructive (vs. destructive) criticism on reduced maladaptive appraisals (namely, shame proneness) diminished as IVC increased, which predicted worsened post‐failure mood. Findings have implications for multidisciplinary theoretical perspectives relevant to interpersonal vulnerability and offer practical considerations for clinicians working with vulnerable clients.
All‐trans retinoic acid reverses epithelial‐mesenchymal transition in paclitaxel‐resistant cells by inhibiting nuclear factor kappa B and upregulating gap junctions
Authors: Shi Guiling , Zheng Xiaoli , Wu Xiaojing , Wang Siqi , Wang Yijia , Xing Fei 
Published: October 2018

Paclitaxel is a widely used chemotherapy drug, but development of resistance leads to treatment failure. Tumor cells that are treated with a sublethal dose of paclitaxel for a long period of time show the epithelial‐mesenchymal transition (EMT) phenotype, which leads to metastasis and resistance. All‐trans retinoic acid (ATRA) is always used in combination with paclitaxel and can reverse EMT in many types of cancer cells. The ability of ATRA to reverse EMT in chemoresistant cells is still unknown. In the present study, the ability of ATRA to reverse EMT in paclitaxel‐resistant cells was investigated. Three colorectal cancer cell lines, HCT116, LoVo and CT26, were treated with sublethal doses of paclitaxel to create resistant cell lines. Western blotting, immunocytochemistry, and “parachute” dye‐coupling assays showed that ATRA reverses EMT, inhibits nuclear factor kappa B (NF‐κΒ), and upregulates gap junctions in paclitaxel‐resistant cells. Scratch wound‐healing and Transwell assays showed that ATRA decreases the migration and invasion abilities of paclitaxel‐resistant cells. In addition, the CT26 cell line was used in the Balb/c pulmonary metastasis model to show that ATRA reduces metastasis of paclitaxel‐resistant cells in vivo. Given these data, ATRA may reverse EMT by inhibiting NF‐κΒ and upregulating gap junctions in paclitaxel‐resistant cells.
The Reciprocal Relations Between Female and Male Play Partners and Aggression in Early Childhood
Authors: Perry Kristin J. , Ostrov Jamie M. 
Published: October 2018

This study examined the relations between male and female play partners (PP) and relational (RA) and physical (PA) aggression in an early childhood short‐term longitudinal study (N = 164, Mage = 47.11 months, SD = 7.37 months). A cross‐lagged path analysis was used to examine these relations from Time 1 (T1) to Time 2 (T2), 4 months after T1, and a multiple group analysis was tested across gender. Results showed that T1 male PP predicted an increase in PA, T1 RA predicted an increase in female PP, and T1 PA predicted a decrease in female PP. One path was not equivalent across gender. A post hoc interaction between male and female PP at T1 on future RA was evaluated.
Quality measures for dental care: A systematic review
Authors: Righolt Amy Joyce , Sidorenkov Grigory , Faggion Clovis Mariano , Listl Stefan , Duijster Denise 
Published: October 2018

AbstractObjectivesThis systematic review aimed to (a) provide an overview of existing quality measures in the field of oral health care, and to (b) evaluate the scientific soundness and applicability of these quality measures.MethodsA systematic search was conducted in three electronic databases MEDLINE (via PubMed), EMBASE (via OVID) and LILACS (via BIREME). The search was restricted to articles published between 2002 and 2018. Publications reporting on the development process or clinimetric properties of oral health care quality measures for outpatient oral health care in dental practices were included. The identified publications reporting on oral health care quality measures were critically appraised with the Appraisal of Indicators through Research and Evaluation 2.0 (AIRE 2.0) instrument to evaluate the soundness and applicability of the measures.ResultsThe search strategy resulted in 2541 unique and potentially relevant articles. In total, 24 publications were included yielding 215 quality measures. The critical appraisal showed a large variation in the quality of the included publications (AIRE scores ranging from 38 to 78 out of 80 possible points). The majority of measures (n = 71) referred to treatment and preventive services. Comparably, few measures referred to the domain patient safety (n = 3). The development process of measures often exhibited a lack of involvement of patients and dental professionals. Few projects reported on the validity (n = 2) and reliability (n = 3) of the measures. Four projects piloted the measures for implementation in practice.ConclusionsThis systematic review provides an overview of the status quo with respect to existing quality measures in oral health care. Potential opportunities include the piloting and testing of quality measures and the establishment of suitable information systems that allow the provision of transparent routine feedback on the quality of oral health care.
Identification of significant coronary artery disease in patients with non‐ST segment elevation acute coronary syndrome by myocardial strain analyses using three‐dimensional speckle tracking echocardiography
Authors: Biswas Asim Kumar , Haque Tuhin , Banik Dhiman , Choudhury Sohel Reza , Khan Sayeedur Rahman , Malik Fazila‐Tun‐Nesa 
Published: October 2018

BackgroundSpeckle‐tracking imaging is a novel method for assessing left ventricular function and ischemic changes. This study aimed to predict the presence of significant coronary artery stenosis in patients with non‐ST‐segment elevation acute coronary syndrome (NSTE‐ACS) by 3D strain analysis using speckle tracking echocardiography (3DSTE) at rest.MethodsThis cross‐sectional study included a total 60 patients with NSTE‐ACS who underwent 3DSTE immediately prior to coronary angiography. Subsequently, patients undergone coronary angiogram (CAG) and divided into two groups; group‐ I: significant stenosis (n = 36), group‐II: non‐significant stenosis (n = 24).ResultsGlobal peak systolic longitudinal strain (GPSLS), circumferential strain (CS), area strain (AS), and radial strain (RS) were obtained successfully in 60 patients. All strain parameters were significantly reduced in patient group of significant stenosis. Receiver operating characteristic (ROC) curve analysis demonstrated that GPSLS could effectively detect patients with significant stenosis (area under ROC curve = 0.840, 95% CI = 0.735–0.945). GPSLS with a cutoff value of −13.50% showed good sensitivity and specificity for predicting significant stenosis (sensitivity 88.9% and specificity 70.8%).ConclusionGlobal peak systolic longitudinal strain using 3D speckle tracking echocardiography at rest was significantly lower in patients with significant stenosis and might be useful for identifying patients with a significant stenosis with good degree of sensitivity and specificity.
Unintended effects of the language policy on the transition of immigrant students to upper secondary education in Catalonia
Authors: Reyes Charo , Carrasco Silvia 
Published: October 2018

AbstractThis article analyses the effects of the language policy in Catalonia on the transition of immigrant students to upper secondary education in Barcelona by focusing on the language learning experiences and academic trajectories of two case‐studies of Pakistani students whose communicative resources remain invisible despite the official celebration of linguistic diversity and which are not properly fostered to ensure their successful incorporation into post‐compulsory education, despite their initial success and high aspirations. Although indicators of educational inequality show how young people born outside the EU experience an alarming disadvantage in comparison to their Spanish‐born peers, little attention has been paid to factors related to the complex bilingual context of Catalonia. This article aims to shed light on the factors involved in the early school leaving of students from immigrant backgrounds, especially critical in the periods of transition, and the role played by the language policies, beliefs and ideology that they are exposed to.
Forcing materialism upon metaphysics: Three approaches to Adorno's method
Authors: Whyman Tom 
Published: October 2018

AbstractRecent Adorno scholarship has been shaped by the idea that his critical theory cannot account coherently for its own method. Call this the Problem of Adornian Critical Theory (PACT). In this paper, I examine three recent approaches to Adorno—the “ethics of resistance” (associated with Gordon Finlayson and Brian O'Connor), “negative naturalism” (associated with Fabian Freyenhagen), and “inverse theology” (associated with Peter E. Gordon). Individually, I argue, all three approaches are subject to a key limitation that prevents them from being able to solve the PACT. But, by synthesising them, we can see how the scholarship already—effectively—possesses a solution to it. The synthesis that results is characterised in terms of “materialist metaphysics”—a position Adorno can clearly be read as articulating in the “Meditations on Metaphysics” chapter of Negative Dialectics.
Subcentimeter epilepsy surgery targets by resting state functional magnetic resonance imaging can improve outcomes in hypothalamic hamartoma
Authors: Boerwinkle Varina L. , Foldes Stephen T. , Torrisi Salvatore J. , Temkit Hamy , Gaillard William D. , Kerrigan John F. , Desai Virendra R. , Raskin Jeffrey S. , Vedantam Aditya , Jarrar Randa , Williams Korwyn , Lam Sandi , Ranjan Manish , Broderson Janna S. , Adelson David , Wilfong Angus A. , Curry Daniel J. 
Published: October 2018

SummaryObjectiveThe purpose of this study is to investigate the outcomes of epilepsy surgery targeting the subcentimeter‐sized resting state functional magnetic resonance imaging (rs‐fMRI) epileptogenic onset zone (EZ) in hypothalamic hamartoma (HH).MethodsFifty‐one children with HH‐related intractable epilepsy received anatomical MRI‐guided stereotactic laser ablation (SLA) procedures. Fifteen of these children were control subjects (CS) not guided by rs‐fMRI. Thirty‐six had been preoperatively guided by rs‐fMRI (RS) to determine EZs, which were subsequently targeted by SLA. The primary outcome measure for the study was a predetermined goal of 30% reduction in seizure frequency and improvement in class I Engel outcomes 1 year postoperatively. Quantitative and qualitative volumetric analyses of total HH and ablated tissue were also assessed.ResultsIn the RS group, the EZ target within the HH was ablated with high accuracy (>87.5% of target ablated in 83% of subjects). There was no difference between the groups in percentage of ablated hamartoma volume (P = 0.137). Overall seizure reduction was higher in the rs‐fMRI group: 85% RS versus 49% CS (P = 0.0006, adjusted). The Engel Epilepsy Surgery Outcome Scale demonstrated significant differences in those with freedom from disabling seizures (class I), 92% RS versus 47% CS, a 45% improvement (P = 0.001). Compared to prior studies, there was improvement in class I outcomes (92% vs 76%‐81%). No postoperative morbidity or mortality occurred.SignificanceFor the first time, surgical SLA targeting of subcentimeter‐sized EZs, located by rs‐fMRI, guided surgery for intractable epilepsy. Our outcomes demonstrated the highest seizure freedom rate without surgical complications and are a significant improvement over prior reports. The approach improved freedom from seizures by 45% compared to conventional ablation, regardless of hamartoma size or anatomical classification. This technique showed the same or reduced morbidity (0%) compared to recent non–rs‐fMRI‐guided SLA studies with as high as 20% permanent significant morbidity.