bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiyear microgrid data from a research building in Tsukuba, Japan
Authors: Vink Karina , Ankyu Eriko , Koyama Michihisa 
Published: February 2019

AbstractMicrogrids comprising renewable energy technologies are often modelled and optimised from a theoretical point of view. Verification of theoretical systems with data of actually implemented systems in the field rarely occurs in an open manner, especially on the intermediate scale of research buildings. To enable modelling of the actual microgrid performance of a research environment, we present a multiyear dataset of a microgrid with solar arrays and a battery. The main energy datasets comprise data per second supplemented by hourly solar irradiation data. These may be combined with data concerning the hourly electricity prices from the main grid and the low-electricity-price periods of national holidays. The level of detail of the data per second in combination with the hourly data in these datasets allows for a comparison to the efficiency and weather-parameter correlation of other renewable energy technologies, as well as forecasting future energy generation and consumption.
Structure of SPH (self-incompatibility protein homologue) proteins: a widespread family of small, highly stable, secreted proteins
Authors: Rajasekar Karthik V. , Ji Shuangxi , Coulthard Rachel J. , Ride Jon P. , Reynolds Gillian L. , Winn Peter J. , Wheeler Michael J. , Hyde Eva I. , Smith Lorna J. 
Published: February 2019

Abstract
SPH (self-incompatibility protein homologue) proteins are a large family of small, disulfide-bonded, secreted proteins, initially found in the self-incompatibility response in the field poppy (Papaver rhoeas), but now known to be widely distributed in plants, many containing multiple members of this protein family. Using the Origami strain of Escherichia coli, we expressed one member of this family, SPH15 from Arabidopsis thaliana, as a folded thioredoxin fusion protein and purified it from the cytosol. The fusion protein was cleaved and characterised by analytical ultracentrifugation, circular dichroism and nuclear magnetic resonance (NMR) spectroscopy. This showed that SPH15 is monomeric and temperature stable, with a β-sandwich structure. The four strands in each sheet have the same topology as the unrelated proteins: human transthyretin, bacterial TssJ and pneumolysin, with no discernible sequence similarity. The NMR-derived structure was compared with a de novo model, made using a new deep learning algorithm based on co-evolution/correlated mutations, DeepCDPred, validating the method. The DeepCDPred de novo method and homology modelling to SPH15 were then both used to derive models of the 3D structure of the three known PrsS proteins from P. rhoeas, which have only 15–18% sequence homology to SPH15. The DeepCDPred method gave models with lower discreet optimised protein energy scores than the homology models. Three loops at one end of the poppy structures are postulated to interact with their respective pollen receptors to instigate programmed cell death in pollen tubes.
The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma
Authors: Sun Xiaoyang , Xie Yu , Sun Xiaoshen , Yao Yao , Li Hujun , Li Zhenyu , Yao Ruosi , Xu Kailin 
Published: February 2019

Abstract
Multiple myeloma (MM) is a hematological malignancy of plasma cells that produce a monoclonal immunoglobulin protein. Despite significant advances in the treatment of MM, challenges such as resistance to therapy remain. Currently, inhibition of histone deacetylases (HDACs) is emerging as a potential method for treating cancers. Numerous HDAC inhibitors are being studied for the use in monotherapy or in conjunction with other agents for MM. In the present study, we investigated the anti-myeloma effect of Nexturastat A (NexA), a novel selective HDAC6 inhibitor. We found that NexA impaired MM cells viability in a dose- and time-dependent manner. NexA also provoked a cell cycle arrest at the G1 phase in MM cells. Furthermore, NexA promoted apoptosis of MM cells via transcriptional activation of the p21 promoter, which may through its ability to up-regulate the H3Ac and H4Ac levels. Additionally, NexA could overcome bortezomib (BTZ) resistance in MM cells, and NexA in combination with BTZ had stronger efficacy. We also confirmed that NexA inhibited tumor growth in murine xenograft models of MM. These interesting findings provided the rationale for the future advancement of this novel HDAC6 inhibitor as a potential therapeutic anti-myeloma agent.
Antibiotic resistance in grass and soil
Authors: Tyrrell Ciara , Burgess Catherine M. , Brennan Fiona P. , Walsh Fiona 
Published: February 2019

Abstract
Antibiotic resistance is currently one of the greatest threats to human health. The global overuse of antibiotics in human medicine and in agriculture has resulted in the proliferation and dissemination of a multitude of antibiotic resistance genes (ARGs). Despite a large proportion of antibiotics being used in agriculture, little is understood about how this may contribute to the overall antibiotic resistance crisis. The use of manure in agriculture is a traditional and widespread practice and is essential for returning nutrients to the soil; however, the impact of continuous manure application on the environmental microbiome and resistome is unknown. The use of antibiotics in animal husbandry in therapeutic and sub-therapeutic doses creates a selective pressure for ARGs in the gut microbiome of the animal, which is then excreted in the faeces. Therefore, the application of manure to agricultural land is a potential route for the transmission of antibiotic-resistant bacteria from livestock to crops, animals and humans. It is of vital importance to understand the mechanisms behind ARG enrichment and its maintenance both on the plant and within the soil microbiome to mitigate the spread of this resistance to animals and humans. Understanding this link between human health, animal health, plant health and the environment is crucial to inform implementation of new regulations and practice regarding antibiotic use in agriculture and manure application, aimed at ensuring the antibiotic resistance crisis is not aggravated.
Detection of Airway Invasion During Flexible Endoscopic Evaluations of Swallowing: Comparing Barium, Blue Dye, and Green Dye
Authors: Curtis James , Perry Sarah , Troche Michelle S. 
Published: February 2019

Purpose
The aim of this study was to assess the effects of barium, blue dye, and green dye on the frequency and reliability of detecting airway invasion (penetration and aspiration) seen during flexible endoscopic evaluations of swallowing (FEES).

Method

Thirty patients with neurodegenerative disease and suspected dysphagia underwent an FEES. Patients were presented with 10-cc boluses of water colored with blue dye, green dye, and barium, within the same examination, in a randomized order. Airway protection outcomes were blindly analyzed by a panel of expert raters. Outcomes included the presence of residue on airway structures (epiglottis, laryngeal vestibule, vocal folds, subglottis) and abnormal Penetration–Aspiration Scale (PAS;
Rosenbek, Robbins, Roecker, Coyle, & Wood, 1996
) scores (PAS ≥ 3). Statistical analyses were performed to determine group differences in the frequency of airway residue and abnormal PAS scores, as well as reliability.

Results

Airway residue was observed most frequently with barium when compared to blue dye (
p
< .05) or green dye (
p
< .05). Abnormal PAS scores were also observed most frequently with barium when compared to blue dye (
p
< .0005) and green dye (
p
< .0005). There were no significant differences in the observed frequency of airway residue nor abnormal PAS scores when comparing blue and green dye (
p
> .05). Intrapanel reliability scores for airway residue and PAS scores, respectively, were very good (
k
= .83) and good (
k
= .67) for barium, very good (
k
= 1.00) and moderate (
k
= .50) for green dye, and moderate (
k
= .47) and fair (
k
= .33) for blue dye.

Conclusion
Airway invasion was detected significantly more frequently and with greater reliability with barium when compared to blue and green dye. Given these findings, standardized use of barium is recommended at some point during FEES, especially when attempting to detect subtle signs of airway invasion.
Single‐image super‐resolution using online kernel adaptive filters
Authors: Anver Jesna , Parambil Abdulla 
Published: February 2019

The online kernel adaptive filters are non‐linear filters which provide impulse response and are more efficient compared to other kernel algorithms. The performance of kernel adaptive filters depends on dictionary size. Here the single‐image super‐resolution using online kernel adaptive filters is a learning‐based method. The algorithm generates a sparser solution for obtaining high‐resolution image from a low‐resolution image. It finds out a dictionary with most significant set of basis vectors using the spatial similarity among the dictionaries created from the low‐resolution and high‐resolution image patches in the training set. The dictionary is utilised to generate the high‐resolution image. The algorithm is analysed on three different kernel adaptive filters, extended kernel recursive least squares, kernel recursive least squares tracker and naive online regularised risk minimisation algorithm. The performance of the super‐resolution method is evaluated on a large number of images and is compared with the state‐of‐the art non‐linear solutions to the super‐resolution. The results show a better progress in peak signal‐to‐noise ratio up to 1.2 dB.
Performance improvement of dynamic PV array under partial shade conditions using M2 algorithm
Authors: Manjunath Matam , Venugopal Reddy Barry , Lehman Brad 
Published: February 2019

Photovoltaic (PV) plants operating under the partial shade condition show an imbalance in the array irradiance and produce less output power. To counteract this problem, reconfigurable PV array or dynamic PV array (DPVA) for changing the inter‐connections of PV modules to balance the irradiance distribution has been proposed previously. This study introduces a new strategy, the maximum and minimum (M2) algorithm, to identify global maximum irradiance configuration with a minimal number of interchanges among the PV modules. For the implementation of DPVA, this study introduces a double pole double throw (DPDT) switch network (SN) with less switch‐count compared to a conventional SN. Simulations of PV array have been carried out on a 9 × 9 size PV array. Results are compared with the previously reported algorithms. Further, cost–benefit analysis of a 10 kWP grid‐tied DPVA plant has been presented. Experimental tests on 4 × 2 size DPVA under different shade conditions are conducted to validate the proposed algorithm and DPDT SN.
Quo vadis non-targeted wine analysis?
Authors: Fauhl-Hassek C. 
Published: February 2019

Important challenges of wine authentication - for example the proof of wine varieties, the determination of the vintage or the geographical origin, the determination of certain practices (e.g. differentiation of barrel/chips storage) become more and more successfully investigated by non-targeted analytical approaches. Not only in relation to these open questions in wine authentication non-targeted approaches such as nuclear magnetic resonance and mass spectrometry offer enormous potential also in wine authentication due to their typical abilities as high-through put and screening technique.
The adaptation from research into routine applications takes actually place in some instances (e.g. NMR) including wine analysis. In addition the combination of non-targeted and targeted approaches within the same run of analysis provides possibilities complementing or even substituting classical methodologies.
Some examples, the general workflow and typical evaluation strategies will be presented and their possibilities and limits discussed. First results of a recent study on the NMR analysis with focus on variety verification and reproducibility of spectral data will be presented. Particular emphasis will be put on general open questions such as exchangeability of data, validation, standardisation options.
los factores de desempeño comercial de los grandes países exportadores en los mercados vitivinícolas de granel y embotellado en el siglo XXI
Authors: Ferrer R.C. López y F.J. Cervera 
Published: February 2019

La economía mundial del vino en el siglo XXI está dominada por el comercio exterior. El aumento de los flujos comerciales ha provocado cambios sustanciales en la industria de la mayor parte de países productores, superando los patrones clásicos “viejo” frente a “nuevo” mundo. En este marco reviste un especial interés el análisis de los factores de evolución de las exportaciones. Esta Comunicación analiza el desempeño de las exportaciones de vino embotellado y a granel de los tres principales exportadores mundiales – España, Italia y Francia – utilizando un conjunto de indicadores formado por su grado de diversificación, su adaptación a los cambios en los mercados de importación y su competitividad según mercados de destino. Los resultados muestran que, en graneles, España, quien más crece en volumen y en valor, tiene el mejor comportamiento en diversificación y competitividad, y el segundo en adaptación, aunque el comportamiento de sus precios haya sido pobre. En embotellados, España también domina el crecimiento de las exportaciones, de forma más clara en volumen que en valor, aunque tiene nuevamente el peor comportamiento en precios y presenta resultados intermedios, obteniendo el mejor resultado en diversificación, el tercero en adaptación y el segundo en competitividad.
Platelet Microtubule Subunit Proteins
Authors: Castle A G , Crawford N 
Published: February 2019

SummaryBlood platelets contain microtubule proteins (tubulin and HMWs) which can be polymerised “in vitro” to form structures which resemble the microtubules seen in the intact platelet. Platelet tubulin is composed of two non-identical subunits a and p tubulin which have molecular weights around 55,000 but can be resolved in alkaline SDS-polyacrylamide gel electrophoresis. These subunits associate as dimers with sedimentation coefficients of about 5.7 S although it is not known whether the dimer protein is a homo- or hetero-dimer. The dimer tubulin binds the anti-mitotic drug colchicine and the kinetics of this binding are similar to those reported for neurotubulins. Platelet microtubules also contain two HMW proteins which appear to be essential and integral components of the fully assembled microtubule. These proteins have molecular weights greater than 200,000 daltons. Fluorescent labelled antibodies to platelet and brain tubulins stain long filamentous microtubular structures in bovine lens epithelial cells and this pattern of staining is prevented by exposing the cells to conditions known to cause depolymerisation of cell microtubules.
Maternal and Infant Adverse Outcomes Associated with Mild and Severe Preeclampsia during the First Year after Delivery in the United States
Authors: Ton Thanh G.N. , Bennett Mihoko V. , Incerti Devin , Peneva Desi , Druzin Maurice , Stevens Warren , Butwick Alexander J. , Lee Henry C. 
Published: February 2019

Objective The burden of preeclampsia severity on the health of mothers and infants during the first year after delivery is unclear, given the lack of population-based longitudinal studies in the United States.
Study design We assessed maternal and infant adverse outcomes during the first year after delivery using population-based hospital discharge information merged with vital statistics and birth certificates of 2,021,013 linked maternal–infant births in California. We calculated sampling weights using the National Center for Health Statistics data to adjust for observed differences in maternal characteristics between California and the rest of the United States. Separately, we estimated the association between preeclampsia and gestational age and examined collider bias in models of preeclampsia and maternal and infant adverse outcomes.
Results Compared with women without preeclampsia, women with mild and severe preeclampsia delivered 0.66 weeks (95% confidence interval [CI]: 0.64, 0.68) and 2.74 weeks (95% CI: 2.72, 2.77) earlier, respectively. Mild preeclampsia was associated with an increased risk of having any maternal adverse outcome (relative risk [RR] = 1.95; 95% CI: 1.93, 1.97), as was severe preeclampsia (RR = 2.80; 95% CI: 2.78, 2.82). The risk of an infant adverse outcome was increased for severe preeclampsia (RR = 2.15; 95% CI: 2.14, 2.17) but only marginally for mild preeclampsia (RR = 0.99; 95% CI: 0.98, 1). Collider bias produced an inverse association for mild preeclampsia and attenuated the association for severe preeclampsia in models for any infant adverse outcome.
Conclusion Using multiple datasets, we estimated that severe preeclampsia is associated with a higher risk of maternal and infant adverse outcomes compared with mild preeclampsia, including an earlier preterm delivery.
Use of Point-of-Care Gastric pH Testing to Assess the Efficacy of Acid Suppression Therapy in the Neonatal Intensive Care Unit
Authors: Ekhaguere Osayame A. , Padula Michael A. , Jensen Erik A. 
Published: February 2019

Objective The use of acid suppression therapies in newborns lacks efficacy and is associated with adverse effects. Point-of-care (POC) assessment of gastric aspirate pH may provide an objective, noninvasive measure of gastric acidity in tube fed infants. We conducted the present study to characterize the POC gastric pH levels in gastric tube fed infants before and after initiation of enteral omeprazole or ranitidine.
Study Design Retrospective cohort study of infants with gastric aspirate pH levels determined by POC pH strips. Gastric pH levels recorded during 7 days before and 14 days after medication initiation were compared using Wilcoxon's sign-rank tests.
Results Among 307 evaluated infants, 284 (92%) had a median gastric pH level ≥4 in 7 days prior to ranitidine or omeprazole. In 14 days after medication initiation, the median gastric pH of infants with pretreatment median gastric pH < 4 increased to 4.5 and 5 (p < 0.01) in the ranitidine and omeprazole groups, respectively. There was no change in infants with pretreatment median gastric pH ≥4.
Conclusion Among infants receiving gastric tube feedings and enteral omeprazole or ranitidine, only those with a pretreatment gastric pH level <4 demonstrated a significant increase in gastric pH. Validation of our findings against esophageal pH multichannel intraluminal impedance testing is needed.
Changes in Platelet Functions, Coagulation and Fibrinolysis in Uncomplicated Cases of Acute Myocardial Infarction
Authors: Bjerre Knudsen J , Gormsen J , Skagen K , Amtorp O 
Published: February 2019

SummaryPlatelet aggregation and serotonin-release in vitro and some coagulation and fibrinolysis parameters were studied closely in 12 patients with non-complicated acute transmural myocardial infarction from the very beginning, for 3 weeks.The aggregability with ADP, epinephrine and collagen and the serotonin-release was significantly reduced the first days. Significantly increased aggregability and serotonin-release developed after a week, with peak activity on days 14–16. Most patients still exhibited increased activity at the discharge on days 21–22.Positive ethanol gelation tests developed after day 1 in most patients with a peak at day 5, contemporary with peak activities of factor VIII and negatively correlated to factor XIII activity, quantitated biologically. These values were normalized on discharge. Antithrombin III (Xa) remained unchanged, normal to slightly elevated.The fibrinolytic activity decreased after day 1 with lowest activity on day 5, contemporary with peak activity of antiplasmin. Around 50% of the patients showed decreased activity on discharge.
Varieties and effects of emotional content in public deliberation
Authors: Lukianova Ekaterina , Tolochin Igor , Fuji Johnson Genevieve , Knobloch Katherine R. 
Published: February 2019

Abstract
The Citizens’ Initiative Review (CIR) is a deliberative process that has been used in the United States to involve panels of citizens in producing balanced and easily understandable accounts of proposed ballot measures and their potential effects. The goal of this paper is to demonstrate how the CIR process is shaped by evaluative framing in which the rational component cannot be clearly separated from the emotive base of assigning responsibility. We analyze the argumentative dynamic of advocates’ presentations during the 2010 CIR on Measure 73 and discuss emotional claims as products of narrative structures that define problem situations. We explore how the distinction between manipulative and valid emotional claims within the context of public deliberation can be made with the help of three categories of analysis: Themes, Ideals, and Scenarios.
Negative Discourse Analysis and utopias of the political
Authors: Graham Phil 
Published: February 2019

Abstract
This paper puts forward an argument about the relation between utopian thought and political discourse. It demonstrates how utopias frame normative discourse in general and political discourse in particular. The argument is informed by Kenneth Burke’s theory of the negative command and its place at the basis of all human language. I argue that utopias are necessarily based in the hortatory negative and are, in literary terms, like religious texts in general being ‘words about words’ designed to coordinate “the tribe”. Burke calls such texts ‘logological’. The argument I put forward here points to a rapidly crumbling utopia that has beset much of the world and all of the West since at least the Reagan-Thatcher era in which a new corporatist political economy was given global impetus.
Crítica en simpatía
Authors: García Miguel Ángel 
Published: February 2019

Abstract
For the first time, we analyze in detail the reading that Pedro Salinas makes of a series of relevant
anthologies for the history of contemporary Spanish poetry: the two anthologies of Gerardo Diego (1932–1934) and the anthologie of
Federico de Onís (1934), among others. Also, we study his theoretical reflection about this genre, which is always supported in
these “criticism with simpathy” that he claims.