bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of selective molecularly imprinted sorbent for the optimized solid‐phase extraction of S‐pramipexole from the model multicomponent sample of human urine
Authors: Woźnica Marcin , Luliński Piotr 
Published: January 2019

AbstractThe objective of this article was to design the selective molecularly imprinted sorbent dedicated to the solid‐phase extraction of S‐pramipexole from the complex matrix such as human urine. For that purpose, S‐2,6‐diamino‐4,5,6,7‐tetrahydrobenzothiazole was used as the template acting as the structural analog of S‐pramipexole and five various monomers were employed in the presence of ethylene glycol dimethacrylate to produce molecularly imprinted polymers. The binding capabilities of resulted polymers revealed that the highest imprinting effect was noted for polymer prepared from the itaconic acid. The comprehensive analysis of morphology and the characterization of binding sites showed not only negligible differences in the extension of surfaces of imprinted and nonimprinted polymers but also higher heterogeneity of binding sites in the imprinted material. Comprehensive optimization of the molecularly imprinted solid‐phase extraction allowed to select the most appropriate solvents for loading, washing, and elution steps. Subsequent optimization of mass of sorbent and volumes of solvents allowed to achieve satisfactory total recoveries of S‐pramipexole from the model multicomponent real sample of human urine that equals to 91.8 ± 3.2% for imprinted sorbent with comparison to only 37.1 ± 1.1% for Oasis MCX.
Value of Real‐Time Shear Wave Elastography Versus Acoustic Radiation Force Impulse Imaging in the Diagnosis of Female Bladder Neck Obstruction
Authors: Qian Mingqin , Jiang Dianyu , Su Chang , Wang Xuesong , Zhao Xia , Yang Shida 
Published: January 2019

ObjectiveTo investigate the application value of shear wave elastography (SWE) and acoustic radiation force impulse imaging (ARFI) in the diagnosis of female bladder neck obstruction (FBNO), we compared the advantages of these 2 methods to provide a more accurate reference for clinical work.MethodsFrom April 2016 to February 2018, 27 patients who were diagnosed with FBNO by cystoscopy and/or urine dynamics testing were selected for the study, together with 24 healthy adults in a case‐control study at Liaoning Province People's Hospital. We collected general information from 27 patients with FBNO, and using transperineal 2‐dimensional ultrasound detection, shear wave elastography (SWE) and ARFI were used, respectively, to detect the Young's modulus and shear wave velocity (SWV) of the bladder necks. Cystoscopy results were considered to be the gold standard, and receiver operating characteristic (ROC) curves were drawn for ARFI, SWE, and the combined diagnosis of the two. The efficacy of the diagnosis was determined by comparing the areas under the ROC curves and calculating the sensitivity, specificity, and accuracy.ResultsThe areas under the ROC curve for the Q‐box mean and max value detected by SWE for FBNO patients were 88.4% and 89.9%, respectively, and the sensitivity, specificity, and accuracy were 81.5%, 79.2%, and 80.4%, respectively. The area under the ROC curve detected by ARFI for FBNO patients was 93.7%, and the sensitivity, specificity, and accuracy were 88.9%, 79.2%, and 84.3%, respectively. The sensitivity, specificity, and accuracy of the combined detection of ARFI and SWE were 92.5%, 87.5%, and 90.2%, respectively. The best diagnostic cutoff point of the SWV or the Q‐box mean and max value of SWE in FBNO obtained with the ROC curve was SWV = 2.38 m/s (sensitivity, 71.4%; specificity, 82.5%), Q‐box mean = 20.2 kPa, Q‐box max = 39.8 kPa (sensitivity, 67.5%; specificity, 76.2%). The average shear wave velocity of ARFI, Q‐box mean, and Q‐box max value of SWE in the control group were 1.89 ± 0.35 m/s, 15.3 ± 3.6 kPa, and 29.2 ± 8.7 kPa, respectively. In the FBNO group, these values were 2.81 ± 0.63) m/s, 27.2 ± 8.6 kPa, and 51.2 ± 12.3 kPa, respectively. The differences were statistically significant (P < .05).ConclusionThe value of the ARFI in the diagnosis of FBNO is a little greater than that of SWE in terms of sensitivity and accuracy, and the combined detection of ARFI and SWE performs better than ARFI or SWE employed separately.
Changes in rhizosphere bacterial and fungal community composition with vegetation restoration in planted forests
Authors: Liu Gui‐yao , Chen Li‐li , Shi Xin‐rong , Yuan Zhi‐you , Yuan Lois Y. , Lock T. Ryan , Kallenbach Robert L. 
Published: January 2019

AbstractSoil microbial communities affect nutrient cycling and ecosystem functioning. However, the variations in microbial diversity and community composition within degraded landscapes remain unclear. Using high‐throughput sequencing of bacterial 16S ribosomal RNA genes and internal transcribed spacer fungal sequences, we investigated the rhizosphere microbial diversity and community of coniferous Pinus tabulaeformis Carr. forests in degraded lands across a chronosequence that spanned over 60 years (10, 25, 40, and 60 years since restoration, four forest stands). We found significant differences in soil bacterial and fungal communities among stand ages. Actinobacteria, Proteobacteria, and Acidobacteria dominated the rhizosphere, whereas Basidiomycota, Ascomycota, and Zygomycota prevailed as fungal components. With stand development, bacterial diversity decreased, but fungal diversity increased. Nonmetric multidimensional scaling analysis separated bacterial community clusters well by stands. Fungal community clusters of 25‐ and 60‐year‐old stands overlapped. The dominant bacteria Acidobacteria showed the highest relative abundance at the 40‐year‐old stands. Soil microbial communities correlated significantly with the macro‐nutrients (soil organic carbon, total nitrogen, and total phosphorous). Additionally, the relative abundance of Acidobacteria at the phylum level correlated positively with soil total phosphorous; Deltaproteobacteria at the class level correlated positively with soil organic carbon and total nitrogen. Thus, restoring vegetation in degraded temperate forests enhanced some macronutrients and influenced microbial communities. Our results revealed that restoring vegetation in degraded lands decreased the diversity of bacterial communities over time. In contrast, the soil fungal diversity increased after restoration, and fungal communities in the 25‐ and 60‐year‐old forest stands overlapped on degraded soils.
Diacylglycerol in Cationic Nanoparticles Stimulates Oxidative Stress‐Mediated Death of Cancer Cells
Authors: Bae Chun‐Sik , Ahn Taeho 
Published: January 2019

AbstractPrevious reports have suggested that cargo‐free cationic nanoparticles (cNP) consisting of cationic monovalent lipids, such as 1,2‐oleoyl‐3‐trimethylammonium‐propane (DOTAP), induce reactive oxygen species (ROS) generation and toxicity in cells. In addition, cNP containing six lysine residues (6K) and cargo (6K‐cNP) exerted synergistic effects on ROS production and cell death in cancer cells. In this study, we investigated the effect of diacylglycerol (DAG) derived from egg phosphatidylcholine in nanoparticles (NP) on ROS‐mediated cellular toxicity. When DAG was incorporated into cNP (D‐cNP) or 6K‐cNP (6K‐D‐cNP) up to 7.8 mol% at the expense of DOTAP, and treated with cells, ROS generation in cancer cells increased further in a DAG concentration‐dependent manner compared with those of both cNP without DAG. Concomitantly, cancer cell viability was more decreased upon the treatment with DAG‐containing cNP. Moreover, D‐cNP or 6K‐D‐cNP exhibited enhanced uptake into cells under endocytosis‐inhibited conditions. Taken together, these results suggested that the presence of DAG in NP stimulated the interaction of NP with cancer cells and the resulting ROS‐mediated cytotoxicity.
Comparison of 311‐nm Titanium:Sapphire laser and 308‐nm excimer laser treatment for vitiligo: A randomized controlled non‐inferiority trial
Authors: Bae Jung Min , Eun Sung Hye , Lee Han Na , Kim Gyong Moon , Grimes Pearl E. , Lee Ji Hae 
Published: January 2019

ObjectivesThe 308‐nm excimer laser (EL) has been widely used for localized vitiligo. The recently developed Titanium:Sapphire laser, emits a wavelength of 311 nm, would be expected to be as effective as excimer laser in treatment of vitiligo but few controlled trials have been reported. We sought to compare the efficacy and safety of the TSL and EL as vitiligo treatments.MethodsA randomized controlled non‐inferiority trial based on split‐body was conducted. Patients with stable vitiligo between June 2016 and May 2017 were enrolled. Paired symmetrical vitiligo lesions were randomized to either the EL or TSL treatment group, and treated with a 308‐nm EL or a 311‐nm TSL twice weekly for 12 weeks. The extent of repigmentation was assessed every 4 weeks, and the non‐inferiority margin was set to 10%. We also recorded any adverse events.ResultsSeventy‐four paired lesions in 21 patients were assigned to both the EL group or TSL group. The mean difference between two groups (EL minus TSL) was −2.862%, and the 95% confidence interval (−6.531% to 0.807%) was lower than the non‐inferiority margin. No serious adverse events were noted in either group.ConclusionsThe Titanium:Sapphire laser showed similar therapeutic effect to excimer laser in localized vitiligo with good safety profiles in this non‐inferiority randomized controlled trial. The Titanium: Sapphire laser can serve as an alternative treatment option for localized vitiligo. Lasers Surg. Med. 51:239–244, 2019. © 2019 Wiley Periodicals, Inc.
Efficacy and safety of intense pulsed light with a KTP filter for the treatment of solar lentigines
Authors: Friedmann Daniel P. , Peterson Jennifer D. 
Published: January 2019

BackgroundOptical energy‐based devices, including intense pulsed light (IPL) and potassium titanyl phosphate (KTP) lasers achieve reduction of pigmented and vascular lesions in a relatively similar number of treatments. This study aimed to evaluate the efficacy and safety of an IPL with a “KTP‐like” filter emitting a wavelength of 525–585 nm for the treatment of solar lentigines on the hands and face.MethodsThis was a single center, prospective, open‐label clinical trial including 16 healthy Caucasian subjects (15 females, mean age, 55 years; skin types II and III) with hand and facial solar lentigines. Subjects were treated with three IPL treatment sessions with a KTP‐like filter conducted at monthly intervals. Follow‐up evaluations were performed 1, 3, and 6 months after the last treatment session. Overall pigmentation improvement, pigmentation clearance per lesion, adverse events, and subject tolerability to treatment were evaluated.ResultsSignificant improvements in facial and hand pigmentation were noted at all follow‐up visits (P < 0.0001). One month after the last treatment session, good to excellent outcomes were noted in 74.6% of treated facial areas and 90% of treated hand regions. Although the effect of treatment gradually declined in both treatment regions over the 6‐month follow‐up period, over 60% of subjects demonstrated good to excellent results at the study end. Clinical effectiveness was further confirmed by the reduction in Melanin Index (MI) following each treatment as compared to baseline. Downtime and complications were minimal.ConclusionsIPL treatment with a KTP‐like filter is a well‐tolerated and effective method for reducing facial and hand pigmentation. Lasers Surg. Med. 51:500–508, 2019. © 2019 Wiley Periodicals, Inc.
Photo‐Crosslinked Elastomeric Bimodal Poly(trimethylene carbonate) Networks
Authors: van Bochove Bas , Schüller‐Ravoo Sigrid , Grijpma Dirk W. 
Published: January 2019

AbstractUsing methacrylated poly(trimethylene carbonate) oligomers unimodal (prepared from one macromer) and bimodal (prepared from two macromers with different molecular weights) photo‐crosslinked networks and structures are prepared by stereolithography. The obtained biodegradable networks are flexible and elastic. Compared to the corresponding unimodal networks, the tensile properties of bimodal poly(trimethylene carbonate) (PTMC) network films are significantly enhanced. Resilient materials with increased toughness and suture retention strengths are obtained. The mechanical properties of the bimodal networks compare favorably with those of unimodal networks prepared previously from PTMC macromers with much higher molecular weights. Tough porous PTMC structures with designed diamond pore network architectures can also be readily prepared by stereolithography. Upon swelling of these PTMC structures in a solvent, the pore sizes and pore size distribution increases while the porosity decreases.
Sulfonyl‐Containing Polyimide Dielectrics with Advanced Heat Resistance and Dielectric Properties for High‐Temperature Capacitor Applications
Authors: Tong Hui , Fu Jing , Ahmad Aftab , Fan Tao , Hou Yudong , Xu Ju 
Published: January 2019

AbstractPolymer dielectrics, with advanced dielectric properties and heat resistance, are critical for high‐temperature capacitors in various applications. However, the high performance of heat resistance and dielectric properties are quite difficult to achieve all together due to their mutual implication. Here, by intensively investigating the correlation between molecular structure and properties, polyimide dielectrics with i) enhanced dielectric constant by introducing sulfonyl group, ii) low dissipation factor by introducing flexible linkage, and iii) highTg(glass transition temperature) by retaining an aromatic structure, are obtained. The sulfonyl‐containing polyimides with different flexible linkages exhibit simultaneously a high dielectric constant (4.50–5.98), low dissipation factor (0.00298–0.00426), and outstanding breakdown strength (most above 500 MV m−1), as well as superior heat resistance (Tg: 244–304 °C). Specifically, the polyimide (SPI‐1) with sulfonyl group in diamine moiety and para‐para linkage shows stable dielectric properties up to 150 °C, and the discharged energy density and charge–discharge efficiency can be as high as 7.04 J cm−3and 91.3% at 500 MV m−1, respectively.
The myotonic dystrophy health index: Japanese adaption and validity testing
Authors: Mori Itsuki , Fujino Haruo , Matsumura Tsuyoshi , Takada Hiroto , Ogata Katsuhisa , Nakamori Masayuki , Innami Keisuke , Shingaki Honoka , Imura Osamu , Takahashi Masanori P. , Heatwole Chad 
Published: January 2019

ABSTRACTIntroductionThe Myotonic Dystrophy Health Index (MDHI) is a disease‐specific, patient‐reported outcome measure. The objective of this study was to translate, evaluate, and validate a Japanese version of the MDHI (MDHI‐J).MethodsWe utilized forward and backward translations and qualitative interviews with 11 myotonic dystrophy type 1 (DM1) participants. We subsequently tested the internal consistency, test–retest reliability, concurrent validity against muscle strength, and 3 quality‐of‐life measures, and the known‐groups validity of the MDHI‐J with 60 adult patients.ResultsThe MDHI‐J was found to be culturally appropriate, comprehensive, and clinically relevant. The MDHI‐J and its subscales had high internal consistency (mean Cronbach's α = 0.91), test–retest reliability (intraclass coefficient 0.678–0.915), and concurrent validity (Spearman's ρ − 0.869 to 0.904). MDHI‐J scores were strongly associated with employment, duration of symptoms, and modified Rankin Scale.DiscussionThe MDHI‐J is suitable and valid to measure patient‐reported disease burden in adult Japanese patients with DM1. Muscle Nerve 59:577–577, 2019
The International Continence Society (ICS) report on the terminology for adult male lower urinary tract and pelvic floor symptoms and dysfunction
Authors: D'Ancona Carlos , Haylen Bernard , Oelke Matthias , Abranches‐Monteiro Luis , Arnold Edwin , Goldman Howard , Hamid Rizwan , Homma Yukio , Marcelissen Tom , Rademakers Kevin , Schizas Alexis , Singla Ajay , Soto Irela , Tse Vincent , de Wachter Stefan , Herschorn Sender ,   On behalf of the Standardisation Steering Committee ICS and the ICS Working Group on Terminology for Male Lower Urinary Tract & Pelvic Floor Symptoms and Dysfunction
Published: January 2019

IntroductionIn the development of terminology of the lower urinary tract, due to its increasing complexity, the terminology for male lower urinary tract and pelvic floor symptoms and dysfunction needs to be updated using a male‐specific approach and via a clinically‐based consensus report.MethodsThis report combines the input of members of the Standardisation Committee of the International Continence Society (ICS) in a Working Group with recognized experts in the field, assisted by many external referees. Appropriate core clinical categories and a subclassification were developed to give a numeric coding to each definition. An extensive process of 22 rounds of internal and external review was developed to exhaustively examine each definition, with decision‐making by collective opinion (consensus).ResultsA Terminology Report for male lower urinary tract and pelvic floor symptoms and dysfunction, encompassing around 390 separate definitions/descriptors, has been developed. It is clinically‐based with the most common diagnoses defined. Clarity and user‐friendliness have been key aims to make it interpretable by practitioners and trainees in all the different specialty groups involved in male lower urinary tract and pelvic floor dysfunction. Male‐specific imaging (ultrasound, radiology, CT, and MRI) has been a major addition whilst appropriate figures have been included to supplement and help clarify the text.ConclusionsA consensus‐based Terminology Report for male lower urinary tract and pelvic floor symptoms and dysfunction has been produced aimed at being a significant aid to clinical practice and a stimulus for research.
Health‐related quality of life, psychosocial functioning, and unmet health needs in patients with sarcoma: A systematic review
Authors: McDonough Joshua , Eliott Jaklin , Neuhaus Susan , Reid Jessica , Butow Phyllis 
Published: January 2019

AbstractObjectiveHealth‐related quality of life (HRQoL), psychosocial distress, and unmet health needs are important patient‐reported outcomes (PROs) for patients with sarcoma treated with curative intent. Syntheses of data on these PROs in patients with sarcoma are limited.MethodsA systematic review of peer‐reviewed literature published between 2007 and 2017 was conducted using five databases, guided by the PRISMA and Cochrane reporting guidelines.ResultsOf 7240 articles identified, 31 were included in this review. Compared with healthy individuals, patients with sarcoma frequently scored lower in physical and psychological HRQoL domains and experienced higher rates of self‐image issues, depression, and suicide. However, outcomes for patients with sarcoma were relatively comparable to those with other malignancies. Anxiety symptoms were more common in the diagnosis phase, while depressive symptoms were more common in the treatment phase. Patients who are older, female, and socially isolated often reported lower HRQoL. As a sarcoma‐specific HRQoL instrument is not available, and all studies have used generic instruments, key issues may have been omitted.ConclusionThere are few studies reporting data for HRQoL, psychosocial issues, or unmet health needs in this population. A sarcoma‐specific HRQoL instrument is needed to accurately describe outcomes in this population. There is a need for further qualitative research to conceptualise the HRQoL issues relevant to this population, against which to map existing HRQoL instruments and guide adaptation or creation of a new instrument.
The interconversion of δ2H values of collagen between thermal conversion reactor configurations
Authors: Reynard Linda M. , Ryan Saskia E. , Tuross Noreen 
Published: January 2019

RationaleDifferent thermal conversion reactor packings result in distinct δ2H values in nitrogen‐containing materials, such as bone collagen. An older ‘traditional’ glassy carbon packing method causes incomplete conversion of N‐containing samples into H2 gas, resulting in altered δ2H values compared with the complete conversion of hydrogen obtained with a chromium‐packed reactor. Given that δ2H values from collagen are gaining importance in palaeoecological and archaeological studies, a determination of the relationship between δ2H values produced with a glassy‐carbon‐packed and a chromium‐packed reactor is needed.MethodsWe obtained δ2H values (normalized on the VSMOW‐SLAP scale) from both glassy‐carbon‐packed (GP) and chromium‐packed (Cr) reactor configurations from bone collagen (n = 231) from a variety of archaeological sites, using a High‐Temperature Conversion Elemental Analyzer (TC/EA) coupled to a Delta Plus XP isotope ratio mass spectrometer.Resultsδ2H values from both methods are linearly correlated (r2 = 0.934) and yield the following interconversion equation, δ2H(Cr) = 1.054 δ2H(GP) + 11.6‰ (95% conf. slope 1.020–1.090, intercept 10.6–12.6), and a mean difference of δ2H(Cr) – δ2H(GP) = 10.1‰ (1 sd 5.2, 1 se 0.3, n = 231).ConclusionsWe recommend adopting this interconversion between δ2H values produced with a glassy‐carbon‐packed and chromium‐packed reactor for bone collagen only, with appropriate propagation of uncertainty.
Highly Efficient, Combinatorial and Catalyst‐Free Approach for the Synthesis of 2‐Benzylidenehydrazono‐3‐phenyl‐4‐thiazolidinone‐5‐acetates in Ethanol
Authors: Jangale Asha D. , Dalal Dipak S. 
Published: January 2019

AbstractWe have designed a sustainable, catalyst‐free, combinatorial protocol for the synthesis of highly functionalized thiazolidinone acetate derivatives via multicomponent reaction of aromatic aldehydes, N‐phenylhydrazinecarbothioamide and dimethoxyacetylenedicarboxylate in the ethanol. A consecutive one pot two step environmentally benign procedure has been developed for the synthesis of 2‐Benzylidenehydrazono‐3‐Phenyl‐4‐Thiazolidinone‐5‐Acetate derivatives by adopting regioselective thermal annulation with the operational simplicity with isolation of pure products without using chromatographic purification.
A Quantitative and Rapid Knoevenagel Condensation Catalyzed by Recyclable Zeolite Imidazole Frameworks
Authors: Kumar Nandigama Satish , Reddy Marri Sameer , Kumar S. Tirumala Santosh , Bheeram Vema Reddy , Mukkamala Saratchandra Babu , Rao L. Chandrasekhara 
Published: January 2019

AbstractWe here report a comparative study on catalytic application of ZIF‐8 and ZIF‐67 for the Knoevenagel condensation of diverse isatins/indeno[1,2‐b]quinoxalin‐11‐nones with malononitrile, quantitatively. Good to excellent yields of product in analytically pure form were isolated without using column chromatography. The presented method was successfully scaled up to gram scale and the catalyst was reused up to 4 successive cycles without considerable loss in its catalytic efficiency.
pH‐Dependent Interaction of Four Different Bile Salts with POPG Liposomes Studied by Dynamic Light Scattering and Second Harmonic Spectroscopy
Authors: Kintali Srinivasarao , Varshney Gopal Kishor , Das Kaustuv 
Published: January 2019

AbstractIn recent years the role of bile salts in colorectal cancer has been gaining importance. In addition, it has been observed that for diseases associated with gastrointestinal tract, the pH becomes slightly acidic. In this report we have investigated the pH dependent bile acid – bile salt transformation on the integrity and permeability of phosphatidyl glycerol (POPG) liposomes by dynamic light scattering and interfacial second harmonic generation spectroscopy. Using four different bile salts whose chemical properties vary widely we have observed that in their neutral form (i.e bile acids) they are able to alter the POPG membrane properties significantly higher compared to their ionic (i. e. bile salts) form. Our results indicate that out of the four bile salts, Sodium Deoxycholate and Sodium Cholate have the potential to damage membranes in the colon as their pKa is closer to the pH measured in the gastrointestinal tract. Therefore, one of the pathways of bile salt induced cytotoxicity in the gastrointestinal tract, may occur due to the potential membrane damaging action of these bile salts at acidic pH.