bluuebunny/crossref_metadata_2025_split huggingface dataset:
Terremoto 19S: un recordatorio para los sistemas de salud
Authors: Fajardo-Dolci Germán 
Published: March 2018

Los desastres sucedidos recientemente en el mundo y en nuestro país nos obligan a recuperar temas dejados en el desván. El terremoto del no tan lejano 1985 dejó huella, lecciones y aprendizajes que nos llevaron a organizarnos y a configurar una sociedad dirigida a la prevención y a la acción. Lo menciono en estos términos porque el temblor del 19 de septiembre de 2017 nos hizo un marcado recordatorio. Si bien como sociedad hemos implementado acciones de prevención –como los simulacros– e incorporado nuevas técnicas de construcción –como el uso de losas nervadas en las casas habitación o el diseño de estructuras dinámicas como la Torre Mayor–, aún somos susceptibles de sufrir daños considerables en caso de sismos.
Bacterial Bioreporter‐Based Mercury and Phenanthrene Assessment in Yangtze River Delta Soils of China
Authors: He Wei , Hu Zong‐Hao , Yuan Sheng , Zhong Wen‐Hui , Mei Yan‐Zhen , Dai Chuan‐Chao 
Published: March 2018

Genetically engineered bacterial whole‐cell bioreporters were deployed to investigate bioavailable mercury (b‐Hg) and phenanthrene (b‐PHE). Characterized by high sensitivity and specificity in aqueous solutions, the bioreporter system could detect in amended soils the concentrations of b‐Hg and b‐PHE in the ranges of 19.6 to 111.6 and 21.5 to 110.9 μg kg−1, respectively. The sensitivity of the system allowed for the combined analysis of b‐Hg and b‐PHE from real environmental samples. Therefore, soil samples from three large refinery facilities were tested, and the results from the instrumental analysis strongly correlated with the ones obtained with the bioreporter method. Large‐scale and fast screening of soil contamination across the Yangtze River Delta in Eastern China was conducted. More than 36% of the samples contained b‐Hg, whereas the fractions of b‐PHE were below the detection limit for all the samples. These results indicated a higher toxicity and more hazardous condition for Hg contamination than for PHE. Population densities and airborne 10‐μm particulate matter (PM10) concentrations were used as parameters for comparison with the spatial distribution of the b‐Hg and b‐PHE fractions. The results revealed that the bioreporters could offer a rapid and cost‐efficient method to test soil samples from contaminated areas and provide a screening tool for environmental risk assessment.Core Ideas
Bacterial biosensor exposure allows the assessment of bioavailable Hg/PHE in soil.
Bacterial biosensors were effective in wide‐range soil screening across the YRD.
Oil refineries and air pollution affect distribution of bioavailable Hg/PHE in YRD soil.
Serum Albumin Level Adjusted Progesterone Level on the Trigger Day is Not a Significant Predictor of Clinical Pregnancy
Authors: Yayla Abide Cigdem , Ozkaya Enis , Kayatas Eser Semra , Devranoğlu Belgin , Bilgic Bulent Emre , Kutlu Tayfun 
Published: March 2018

Objective: We aimed to assess the effect of serum albumin level adjusted progesterone levels on the trigger day on clinical pregnancy rate in ICSI cycles.Study Design: A total of 100 women undergoing ICSI cycles due to poor ovarian reserve or tubal factor infertility were included in this study. Serum progesterone and albumin levels on the trigger day were utilized to predict clinical pregnancy among normal and poor responders.Results: There were significant differences between groups with and without successful clinical pregnancy in terms of serum albumin (4.6 vs. 4.3 g/dl), progesterone levels (0.5 ng/mL vs. 0.7 ng/mL) on the trigger day and endometrial thickness (11.5 mm vs. 9.3 mm) (p<0.05, p<0.05 and p<0.05, respectively). In ROC analyses, progesterone level on the trigger day was found to be a significant predictor of clinical pregnancy (AUC=0.652, p=0.015). An optimal cut-off value of 0.55 ng/mL was obtained with 65% sensitivity and 57% specificity. Albumin level adjusted progesterone concentrations on the trigger day were 0.67 ng/mL versus 0.64 ng/mL, but this difference was not statistically significant (p>0.05). Conclusion: Albumin adjusted progesterone concentrations may be utilized to determine cases for a freeze-all policy.
Osteoclastogenesis in Periodontitis: Signaling Pathway, Synthetic and Natural Inhibitors
Authors: Ketherin Ketherin , Sandra Ferry 
Published: March 2018

Osteoclast activities are responsible for the resorption of bone cells found in several bone diseases, one of which is periodontitis and arthritis. The downregulating signals of Receptor Activator of Nuclear Factor kB (RANK)-RANK Ligand and Tumor Necrosis Factor (TNF)-a are the major cause of the bone destruction. Studies and experiments have been performed to overcome this matter. Various medications are now available to treat bone-related diseases, targeting the specific aspect of the signaling. Synthetic drugs such as denosumab and bisphosphonates have complex pharmacological action and have been the leading choice in treatment. Evidence in studies proved that natural resources including herbal products have potential application to therapy for bone loss, with caffeic acid and Caffeic Acid Phenethyl Ester (CAPE) showing significant inhibitory results and Chinese herbs such as Herba epimedii (Yín Yáng Huò) and Fructus psoraleae(Bǔ Gǔ Zhī) proved to contain components that give similar effects to estrogen. The purpose of this review is to discuss the therapy value of available synthetic and natural therapeutic agents. Understanding the mechanisms of both agents will not only clarify their function as therapeutic agents, but can also be the key to the treatment of diseases caused by bone resorption by targeting specific aspects of osteoclastogenesis.Keywords: osteoclastogenesis, TNF, RANKL, bone resorption, natural resource, signaling, treatment
Angiogenesis Intensity within Benign and Malignant Oral Mucosa Epithelial Tumor
Authors: Sudiono Janti , Thalib Sofia 
Published: March 2018

Background: Angiogenesis is an important and fundamental process for new blood vessels to provide nutrients and oxygen needed by tumor cells to grow, develop, and in case of cancer also to metastasize into other organs. This study aims to evaluate the intensity of angiogenesis within benign (papillomas) and malignant (squamous cell carcinoma) epithelial tumors.Materials and methods: This analytic observational study with cross-sectional design using histopathology slide sample that were clinically diagnosed as squamous cell carcinoma (n=3) and papilloma (n=3). Microscopically, the angiogenesis characterized with lumen lined by endothelial cells with or without red blood cells inside within sub epithelial connective tissue of papilloma and squamous cell carcinoma by Hematoxylin Eosin stain. Angiogenesis intensity was counted from four areas under magnification of (10x10), each area was scored under (10x40) magnification.Results: Angiogenesis intensity of papilloma and squamous cell carcinoma are (45.17±14.573) and (55.18±6.26041) respectively. T-test analysis showed there was no significant difference (p=0.336>0.05).Conclusions: Angiogenesis intensity of papilloma is less than those of squamous cell carcinoma.Keywords: angiogenesis, oral epithelial tumor, benign, malignant
Virtual Combinatorial Library Design, Synthesis and In vitro Anticancer Assessment of -2-Amino-3-Cyanopyridine Derivatives
Authors: Dev Sanal , Dhaneshwar Sunil. R. , Mathew Bijo 
Published: March 2018

Aim and Objective:
For the development of new class of anticancer agents, a series of
novel 2-amino-3-cyanopyridine derivatives were designed from virtual screening with Glide
program by setting Topoisomerase II as the target.

Materials and Methods:
The top ranked ten molecules from the virtual screening were synthesized
by microwave assisted technique and investigated for their cytotoxic activity against MCF-7 and A-
549 cell lines by using sulforhodamine B assay method.

Results:
The most active compound 2-amino-4-(3,5-dibromo-4-hydroxyphenyl)-6-(2,4-
dichlorophenyl) nicotinonitrile (CG-5) showed significant cytotoxic profile with (LC50 = 97.1, TGI =
29.9 and GI50 = <0.1 µM) in MCF-7 and (LC50= 93.0, TGI= 50.0 and GI50= <7 µM) in A-549 cell
lines. A molecular docking study was performed to explore the binding interaction of CG-5with the
active site of Topoisomerase II.

Conclusion:
It can be concluded that halogen substituent pyridine ring was benefit for cytotoxicity.
The Analysis of Geospatial Information for Validating Some Numbers of Islands in Indonesia
Authors: Martha Sukendra - 
Published: March 2018

This article discusses a comparison of various numbers of islands in Indonesia; and it addresses a valid method of accounting or enumerating numbers of islands in Indonesia. Methodology used is an analysis to compare the different number of islands from various sources. First, some numbers of Indonesian islands were derived from: (i) Centre for Survey and Mapping- Indonesian Arm Forces (Pussurta ABRI) recorded as 17,508 islands; (ii) Agency for Geospatial Information (BIG) previously known as National Coordinating Agency for Surveys and Mapping (Bakosurtanal) as national mapping authority reported with 17,506 islands (after loosing islands of Sipadan and Ligitan); (iii) Ministry of Internal Affair published 17,504 islands. Many parties have referred the number of 17,504 islands even though it has not yet been supported by back-up documents; (iv) Hidrographic Office of Indonesian Navy has released with numbers of 17,499; (v) Other sources indicated different numbers of islands, and indeed will imply to people confusion. In the other hand, the number of 13,466 named islands has a strong document (Gazetteer). Second, enumerating the total number of islands in Indonesia can be proposed by three ways: (i) island census through toponimic survey, (ii) using map, and (iii) applying remote sensing images. Third, the procedures of searching valid result in number of islands is by remote sensing approach - high resolution satellite images. The result of this work implies the needs of one geospatial data source (including total numbers of islands) in the form of ‘One Map Policy’ that will impact in the improvement of Indonesian geographic data administration.
Performance on the Nephrology In-Training Examination and ABIM Nephrology Certification Examination Outcomes
Authors: Jurich Daniel , Duhigg Lauren M. , Plumb Troy J. , Haist Steven A. , Hawley Janine L. , Lipner Rebecca S. , Smith Laurel , Norby Suzanne M. 
Published: March 2018

Background and objectives
Medical specialty and subspecialty fellowship programs administer subject-specific in-training examinations to provide feedback about level of medical knowledge to fellows preparing for subsequent board certification. This study evaluated the association between the American Society of Nephrology In-Training Examination and the American Board of Internal Medicine Nephrology Certification Examination in terms of scores and passing status.

Design, setting, participants, & measurements
The study included 1684 nephrology fellows who completed the American Society of Nephrology In-Training Examination in their second year of fellowship training between 2009 and 2014. Regression analysis examined the association between In-Training Examination and first-time Nephrology Certification Examination scores as well as passing status relative to other standardized assessments.

Results
This cohort included primarily men (62%) and international medical school graduates (62%), and fellows had an average age of 32 years old at the time of first completing the Nephrology Certification Examination. An overwhelming majority (89%) passed the Nephrology Certification on their first attempt. In-Training Examination scores showed the strongest association with first-time Nephrology Certification Examination scores, accounting for approximately 50% of the total explained variance in the model. Each SD increase in In-Training Examination scores was associated with a difference of 30 U (95% confidence interval, 27 to 33) in certification performance. In-Training Examination scores also were significantly associated with passing status on the Nephrology Certification Examination on the first attempt (odds ratio, 3.46 per SD difference in the In-Training Examination; 95% confidence interval, 2.68 to 4.54). An In-Training Examination threshold of 375, approximately 1 SD below the mean, yielded a positive predictive value of 0.92 and a negative predictive value of 0.50.

Conclusions
American Society of Nephrology In-Training Examination performance is significantly associated with American Board of Internal Medicine Nephrology Certification Examination score and passing status.
Muižu kultūras vērtību aizsardzība Cēsu apriņķī 1919. un 1920. gadā
Authors: Zaļuma Kristīne 
Published: March 2018

Rakstā aplūkots muižu kultūras vērtību aizsardzības pasākumu komplekss Cēsu apriņķī 1919. un 1920. gadā, to galvenokārt realizēja Latvijas Pagaidu valdības Izglītības ministrijas deleģētie kultūras vērtību aizsardzības pilnvarnieki divos apriņķa apgabalos. Raksta mērķis ir atspoguļot muižu kultūras vērtību aizsardzības organizēšanas apstākļus Cēsu apriņķī, uzsverot šo procesu nozīmīgumu Latvijas atbrīvotajā daļā, kas vēl nesen bija atradusies tiešā frontes līnijā. Sarežģītos apstākļos Latvijas Pagaidu valdība bez rūpēm par pārtiku un saimnieciskās dzīves problēmām uzdrošinājās atrast līdzekļus un deleģēt pienākumus cilvēkiem, kuru uzdevums bija apzināt saglabājušās muižu kultūras vērtības un organizēt to aizsardzību.
Mainoties ģeopolitiskajai situācijai un veidojot valstī stabilus pamatus, Latvijas pārvaldes institūcijas lēma kustamās kultūras vērtības pārvietot, uzkrāt un saglabāt, par nozīmīgu kultūras mantojuma daļu atzīstot arī kultūras vērtības, kas vēsturiski bija koncentrējušās muižās. Rakstā kā avoti galvenokārt izmantoti Latvijas Nacionālā arhīva un Latvijas Nacionālās bibliotēkas materiāli.
UM POUCO DE RESISTÊNCIA E LUTA NÃO FAZ MAL À NINGUÉM: INTERFACES PEDAGÓGICAS E MOVIMENTO INTERFACES COMO ESPAÇO DE FORMAÇÃO CONTRA HEGEMÔNICO
Authors: Bresolin Felipe Treviso , Ferreira Samuel Crissandro Tavares , Chaigar Vânia Alves Martins 
Published: March 2018

O presente trabalho tenta organizar e sistematizar uma relação do evento Interfaces Pedagógicas e de seu desdobramento chamado Movimento Interfaces, com as atividades e participações de movimentos de resistência e de luta na cidade. É importante ressaltar que o Interfaces Pedagógicas desde o ano de 2013 se coloca na perspectiva de fortalecer as licenciaturas e o diálogo das mesmas na universidade e seus espaços, ao mesmo tempo que propõem uma interlocução com os espaços para além da universidade. O Movimento Interfaces aparece como complemento a partir do ano de 2016, para dar continuidade as discussões e reflexões demandadas. Dito isso, o trabalho tenta abordar de forma crítica às contribuições que foram trazidas aos eventos pelos movimentos sociais inseridos na cidade e que podem nos alertar quanto a epistemologia de resistências e que em tempos de retrocessos políticos e sociais aparecem como alternativas contra hegemônicas. Palavras-Chave: Cidade, Interfaces Pedagógicas, Movimento Interfaces, Movimentos Sociais, Resistência.
Escuta aos estudantes: Principio pedagógico na educação de jovens e adultos
Authors: Rodrigues madeira Cristiane , Oliveira Everton Fêrrêr de Oliveira 
Published: March 2018

Resumo O presente trabalho tem como objetivo investigar os motivos sobre o retorno dos sujeitos não alfabetizados para as salas de Educação de Jovens e Adultos, bem como aquilo que pensam, e esperam ao estarem nesta modalidade de ensino. Para tanto realizei uma pesquisa na escola EMEF - Escola Municipal de Ensino Fundamental (Escola Pública Municipal) da cidade de Jaguarão - RS a fim de conhecer esses indivíduos e assim compreender, as causas que eles apontam para a volta a escola, depois da ausência de muitos anos do estudo. Como forma de reunir dados acerca da temática, lancei uso de um roteiro de entrevista semiestruturada e roda de conversa com os estudantes. Quanto à fundamentação teórica tratei de reunir estudos sobre o ensino e aprendizagem, seus modelos pedagógicos, suas concepções epistemológicas ligadas a Alfabetização e Educação de Jovens e Adultos. A iniciativa não possui dimensões grandes, mas espero auxiliar em minimizar a dúvida que move meu trabalho, e assim trazer alguma contribuição para outros educadores e educandos sobre a necessidade de conhecimento, acerca das motivações deste público trabalhador, que vence anos de preconceito e dependência de outras pessoas, no mundo letrado em que vivemos.
Smart Devices Threats, Vulnerabilities and Malware Detection Approaches: A Survey
Authors: D BalaGanesh , Chakrabarti Amlan , Midhunchakkaravarthy Divya 
Published: March 2018

In recent times, malware detection mechanism systems of mobile smart devices are getting growing concentration from researchers. With the quick expansion of malwares found in mobile devices, preventing the secrecy of mobile users is incredibly imperative and necessary. Intrusion detection systems are programming devices that consequently assemble information, dissect it and recognize such occurrences. These systems advanced to intrusion aversion systems (IPS) including extra counteractive action capacities. In Intrusion detection systems, accuracy rate plays a significant role in measuring the effectiveness of an approach. One of the motivations of this study is to increase the true positive as well as reducing the false-positive rates beyond other studies.
A Comprehensive Review of the Diagnostic and Treatment Methods for Ovarian Cancer
Authors: Davis Michelle 
Published: March 2018

Ovarian cancer is amongst the most life-threatening malignancy of the female reproductive system, whereas 90% of those ovarian cancers are epithelial with an overall poor five-year survival rate of 44% across all stages and all races [1]–[2], [31]. This paper aims to review the current treatment and diagnostic strategies for ovarian cancer [3]. Using grounded substantial research, multiple figures were developed to show the relations of ovarian cancer diagnostics and ovarian cancer therapeutics. It is a great start to look into what may be causing most patients to become resistant to the current standard of care, platinum-based chemotherapeutics, for ovarian cancer [4]. A comprehensive literature review will be used to understand the genetic basis of the disease and possible cancer growth patterns, so we could possibly introduce better diagnostics and therapeutics [5]. The findings show that there are a variety of treatments options other than the standard of care, platinum-based therapy [6]. Nanoparticle encapsulation therapy is one way that has been approved by the FDA to therapeutically treat ovarian cancer without the platinum resistant side effects [7]. Also, the discovery of different diagnostics for ovarian cancer can help with better individualized treatments for patients with different forms of ovarian cancer [8]. Currently, the only serous diagnostic test for the detection of ovarian cancer is high levels of Cancer Antigen 125 (CA-125), which is only shown in 50% of early staged ovarian cancers [16]. The main treatment option for ovarian cancer is platinum-based drugs, in which most cases of patients with ovarian cancer will become resistant. Detecting and treating ovarian cancer while the cells are small, contained, and still in the early stages in vivo still remains to be a challenge [9]. Here, we will demonstrate the bioelectrical interactions of the ovarian cancer cells fused with the magnetic iron oxide nanoparticles with the use of an MRI. The findings demonstrate that the diagnostic method for the early detection of epithelial ovarian cancer requires the use of magnetic iron oxide nanoparticles with specific ligand external profiles as a contrast reagent to make the small-sized ovarian cancer cells appear more visible under MRI.
Variación y normalización de la lengua maya.
Authors: Lehmann Christian 
Published: March 2018

Se definen los conceptos de variación, estandarización y normalización, aduciéndose ejemplos de varias lenguas. Los conceptos se aplican al maya yucateco, tomándose como caso concreto y actual la obra editada por Briceño Chel y Can Tec, Normas de escritura para la lengua maya (2014). En la discusióncrítica, se muestra de qué sirve la estandarización, cual es su base teórica, a cuales aspectos de la lengua se aplica y como se hace en concreto. La discusión concluye con recomendaciones para la próxima edición de esas Normas. Original recibido: 2016/05/24Dictamen entregado al autor: 2017/06/03Aceptado: 2017/07/06
La importancia de la gestualidad en el estudio del maya yucateco actual.
Authors: Le Guen Olivier 
Published: March 2018

Durante siglos, la descripción lingüística estuvo muy limitada debido a que no se contaba con la posibilidad de grabar en audio y video. Por esta razón, se dejó de lado la naturaleza intrínsecamente multimodal del lenguaje humano, la cual incluye varios tipos de información tanto prosódica como visual. En este trabajo se discuten las formas en que los gestos complementan el habla, lo que incluye varios niveles de análisis: pragmático, semántico y sintáctico, para finalizar con el estudio de gestos que fungen como signos lingüísticos. Para lograr este objetivo, se toma como ejemplo la lengua maya yucateca hablada en la actualidad y se exponen ejemplos de producciones espontáneas. Si bien ciertos procesos descritos en este trabajo son específicos del maya yucateco, la mayor parte no se limita a esta lengua. Se comienza con la definición de lenguaje, habla y gestos; y cómo se puede estudiar la forma en que se integran el habla y los gestos en una oración compuesta. Posteriormente se analizan ejemplos de diferentes tipos de gestos en varias áreas de la comunicación en maya yucateco, como son los gestos deícticos, el uso de los gestos con expresivos, en las metáforas y en la integración de los gestos al nivel pragmático. Finalmente, se explica cómo los gestos pueden llegar a ser signos lingüísticos en maya yucateco. Original recibido: 2016/09/15Dictamen enviado al autor: 2017/03/25Aceptado: 2017/11/07
PEWARISAN PADA MASYARAKAT ADAT BALI TERKAIT AHLI WARIS YANG BERALIH AGAMA
Authors: Jayantiari I G. A. Mas Rwa , Atmadja Ida Bagus Putra , Sukerti Ni Nyoman , Dewi I G. A. Tirta Sari , Agastya Pradnyana I G. A Bagus 
Published: March 2018

Penelitian ini bertujuan untuk menggali dan menganlisis tentang kedudukan ahli waris yang beralih agama dalam hal hak dan kewajibannya baik dalam keluarga maupun dalam masyarakat adat serta akibat hukum yang timbul terkait ahli waris yang beralih agama tersebut. Penelitian ini merupakan penelitian hukum empiris, dengan pendekatan non doktrinal (socio legal reseach). Data digali dengan metode wawancara, selanjutnya dianalisis secara kualitatif. Hasil penelitian menunjukan bahwa ahli waris yang beralih agama tidak lagi berkedudukan ahli waris. Akibatnya ahli waris yang bersangkutan gugur hak warisnya dari orang tuanya. Gugurnya hak mewaris berakibat tidak ada kewajiban-kewajiban yang harus dipikulnya baik kewajiban terhadap keluarga maupun terhadap masyarakat adat. Ahli waris yang beralih agama dikaji dari teorinya Lawrence M. Friedman tentang sistem hukum terdiri dari tiga unsur yaitu struktur hukum, substansi hukum dan budaya hukum, dimana dari ketiga unsur itu tidak mengalami perkembangan. Dengan demikian hukum adat waris Bali masih dipertahankan secara utuh.