bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report
Authors: Cook Lucy B. , Fuji Shigeo , Hermine Olivier , Bazarbachi Ali , Ramos Juan Carlos , Ratner Lee , Horwitz Steve , Fields Paul , Tanase Alina , Bumbea Horia , Cwynarski Kate , Taylor Graham , Waldmann Thomas A. , Bittencourt Achilea , Marcais Ambroise , Suarez Felipe , Sibon David , Phillips Adrienne , Lunning Matthew , Farid Reza , Imaizumi Yoshitaka , Choi Ilseung , Ishida Takashi , Ishitsuka Kenji , Fukushima Takuya , Uchimaru Kaoru , Takaori-Kondo Akifumi , Tokura Yoshiki , Utsunomiya Atae , Matsuoka Masao , Tsukasaki Kunihiro , Watanabe Toshiki 
Published: January 2019

Purpose Adult T-cell leukemia-lymphoma (ATL) is a distinct mature T-cell malignancy caused by chronic infection with human T-lymphotropic virus type 1 with diverse clinical features and prognosis. ATL remains a challenging disease as a result of its diverse clinical features, multidrug resistance of malignant cells, frequent large tumor burden, hypercalcemia, and/or frequent opportunistic infection. In 2009, we published a consensus report to define prognostic factors, clinical subclassifications, treatment strategies, and response criteria. The 2009 consensus report has become the standard reference for clinical trials in ATL and a guide for clinical management. Since the last consensus there has been progress in the understanding of the molecular pathophysiology of ATL and risk-adapted treatment approaches. Methods Reflecting these advances, ATL researchers and clinicians joined together at the 18th International Conference on Human Retrovirology—Human T-Lymphotropic Virus and Related Retroviruses—in Tokyo, Japan, March, 2017, to review evidence for current clinical practice and to update the consensus with a new focus on the subtype classification of cutaneous ATL, CNS lesions in aggressive ATL, management of elderly or transplantation-ineligible patients, and treatment strategies that incorporate up-front allogeneic hematopoietic stem-cell transplantation and novel agents. Results As a result of lower-quality clinical evidence, a best practice approach was adopted and consensus statements agreed on by coauthors (> 90% agreement). Conclusion This expert consensus highlights the need for additional clinical trials to develop novel standard therapies for the treatment of ATL
Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Retrospective Multinational Study
Authors: Pui Ching-Hon , Rebora Paola , Schrappe Martin , Attarbaschi Andishe , Baruchel Andre , Basso Giuseppe , Cavé Hélène , Elitzur Sarah , Koh Katsuyoshi , Liu Hsi-Che , Paulsson Kajsa , Pieters Rob , Silverman Lewis B. , Stary Jan , Vora Ajay , Yeoh Allen , Harrison Christine J. , Valsecchi Maria Grazia ,   on behalf of the Ponte di Legno Childhood ALL Working Group
Published: January 2019

PURPOSE We determined the prognostic factors and utility of allogeneic hematopoietic cell transplantation among children with newly diagnosed hypodiploid acute lymphoblastic leukemia (ALL) treated in contemporary clinical trials. PATIENTS AND METHODS This retrospective study collected data on 306 patients with hypodiploid ALL who were enrolled in the protocols of 16 cooperative study groups or institutions between 1997 and 2013. The clinical and biologic characteristics, early therapeutic responses as determined by minimal residual disease (MRD) assessment, treatment with or without MRD-stratified protocols, and allogeneic transplantation were analyzed for their impact on outcome. RESULTS With a median follow-up of 6.6 years, the 5-year event-free survival rate was 55.1% (95% CI, 49.3% to 61.5%), and the 5-year overall survival rate was 61.2% (95% CI, 55.5% to 67.4%) for the 272 evaluable patients. Negative MRD at the end of remission induction, high hypodiploidy with 44 chromosomes, and treatment in MRD-stratified protocols were associated with a favorable prognosis, with a 5-year event-free survival rate of 75% (95% CI, 66.0% to 85.0%), 74% (95% CI, 61.0% to 89.0%), and 62% (95% CI, 55.0% to 69.0%), respectively. After exclusion of patients with high hypodiploidy with 44 chromosomes and adjustment for waiting time to transplantation and for covariables in a Poisson model, disease-free survival did not differ significantly ( P = .16) between the 42 patients who underwent transplantation and the 186 patients who received chemotherapy only, with an estimated 5-year survival rate of 59% (95% CI, 46.5% to 75.0%) versus 51.5% (95% CI, 44.7% to 59.4%), respectively. Transplantation produced no significant impact on outcome compared with chemotherapy alone, especially among the subgroup of patients who achieved a negative MRD status upon completion of remission induction. CONCLUSION MRD-stratified treatments improved the outcome for children with hypodiploid ALL. Allogeneic transplantation did not significantly improve outcome overall and, in particular, for patients who achieved MRD-negative status after induction.
From Korea to Vietnam
Authors: Chung Patrick 
Published: January 2019

AbstractThis article provides a prehistory of the “container revolution” that occurred during the Vietnam War. It situates containerization in Vietnam within the broader history of US military-led capitalist globalization, demonstrating how US military contracting influenced the development of labor relations and business practices around the globe. Starting in Korea, US military leaders implemented a range of policies to promote cost savings and efficiencies in the construction and operation of its supply chains. Of most consequence was its promotion of racialized labor practices and privatization. These distinct but interrelated processes spoke to the US military’s complicity in the exploitation of workers in the pursuit of cost savings. Further, they ultimately led to the US military’s embrace of containerization. Though the negative impact for workers was abundantly clear even at the time of Vietnam, the US military rigorously promoted the technology and helped make the “box” the standard in the shipping industry.
The Military Grammar of Agrarian Reform in Peru
Authors: Puente Javier 
Published: January 2019

AbstractThis article places the 1969 Peruvian agrarian reform as a defining moment in the history of Latin American militarism and rural capitalism. By unpacking agrarian reform and the rhetorical transformation of indios into campesinos, this article reveals how General Juan Velasco’s military government (1968–75) enforced economic, ideological, and social discipline through a seemingly empowering language of revolution. Capitalizing on enduring radical demands for land redistribution, Velasco’s military-controlled state co-opted claims for land and social justice promoting a revolutionary message against imperial and oligarchic domination while drawing rural populations into more exploitative social relations. The same social and economic reforms meant to benefit thousands of campesinos through access to land facilitated an unprecedented scenario of rural and agrarian capitalism. Once the military garnered social consent, lands and lives fell under state surveillance, decimating communal autonomies, threatening family subsistence, and unleashing mounting degrees of violence against campesino dissidence and resistance.
Indigenous Resistance in an Era of Climate Change Crisis
Authors: Niheu Kalamaoka’aina 
Published: January 2019

Abstract
In an era of climate change crisis precipitated by global extraction of resources and defended by a military-industrial complex, Kanaka Maoli, or the First Peoples of Hawai’i, have struggled over the decades to resist the militarization of our homeland. The struggle for return of land is intrinsically tied to the resistance to military and the capitalistic exploitation via the development, occupation, and sale of our homelands. By exploring the key struggles of the Kalama Valley and Wai’ahole/Waikane resistance, the reawakening of culture reveals how indigenous systems of sustainability, based on traditional technology and science, provide a pathway forward during these troublesome times.
Comparison of three heterochromatin protein 1 homologs in Drosophila
Authors: Lee Dong Hoon , Ryu Hyun Wook , Kim Go Woon , Kwon So Hee 
Published: January 2019

ABSTRACT
Heterochromatin protein 1 (HP1) is an epigenetic regulator of chromatin structure and genome function in eukaryotes. Despite shared features, most eukaryotes have a minimum of three HP1 homologs with differential localization patterns and functions. Most studies focus on Drosophila HP1a [also known as Su(var)205], and little is known about the properties of HP1b and HP1c. To determine the features of the three HP1 homologs, we performed the first comprehensive comparative analysis of Drosophila HP1 homologs. HP1 differentially homodimerizes and heterodimerizes in vivo and in vitro. HP1b and HP1c, but not HP1a, are localized to both the nucleus and cytoplasm. The C-terminal extension region (CTE) targets HP1c and HP1b to the cytoplasm. Biochemical approaches show that HP1 binds to various interacting partners with different binding affinities. Each HP1 associates differently with RNA polymerase II; a gene reporter assay revealed that HP1a and HP1b, but not HP1c, inhibit transcriptional activity, suggesting that HP1c serves as a positive regulator in transcription. Thus, these studies provide the basic clues pertaining to the molecular mechanism by which HP1 might control cellular processes in a homolog-specific manner.
The clinicopathologic features and response to treatment of patients with Nonhodgkin Lymphoma: A single-center experiment in Turkey
Authors: Yildirim Rahsan , Sincan Gulden 
Published: January 2019

Objective: We aimed to compare laboratory features, histopathological types, response to treatment of patients with non hodgkin lymphoma in our department and other regions.
Methods: A total of 80 patients nonhodgkin lymphoma were evaluated. Because we had only 80 patients with complete data, we used T test for comparison of groups. We evaluated the parameters affecting surveillance with cox regression analysis.
Results: The most common histological types of nonhodgkins lymphoma was diffuse large b cell lymphoma (n: 63, 78.75%). Thirty-nine percent of all patients had anemia, 32% had hypoalbunemia, 71.25% had elevated serum LDH, 32.5% had elevated serum ß2 microglobulin value. Advanced age, the presence of bulky disease, elevated Ki-67 level, IPI score, refractory to first line treatment were found to be correlated with shorter survival time. We treated 77 (96.25%) patients with doxorubicin containing regimen. Complete and partial remission rates of first line treatment were 77.5% and 10%, respectively. Seven (8.75%) patients died because of disease progression and 1 (1.25%) patient died due to sepsis.
Conclusion: The frequency of lymphoma subtypes, clinical characteristics, treatment outcomes and survival rate vary from region to region. Therefore it is important to determine dissimilarity of these parameters for improve of survey.
How to cite this:Yildirim R, Sincan G. The clinicopathologic features and response to treatment of patients with Nonhodgkin Lymphoma; A single-center experiment in Turkey. Pak J Med Sci. 2019;35(1):82-85. doi: https://doi.org/10.12669/pjms.35.1.415
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Oberflächliche Phlebitis und Venenthrombose der oberen Extremität – banal oder nicht?
Authors: Recke A. L. , Kahle B. 
Published: January 2019

Zusammenfassung
Hintergrund: Armvenenthrombosen (AVT) und oberflächliche Phlebitiden der oberen Extremität spielen in der phlebologischen Literatur eher eine Nebenrolle.
Fragestellung: Werden AVT und oberflächliche Phlebitiden der Armvenen im klinischen Alltag unterschätzt?
Methodik: Literaturrecherche in medizinischen Datenbanken unter Verwendung folgender Stichworte: venous thrombosis, upper extremity, venous catheter, pulmonary embolism, thoracic outlet, varicose veins in upper limbs, superficial phlebitis upper extremity/ limb
Ergebnisse: AVT treten bevorzugt nach Anlage von Venenkathetern oder Venenverweilkanülen auf. Malignome sind an zweiter Stelle als ätiologisch relevant zu nennen. Neurovaskuläre Kompressionssyndrome spielen eine untergeordnete Rolle. Oberflächliche Phlebitiden der Armvenen finden in der Literatur wenig Erwähnung, die Erkenntnisse sind heterogen.
Zusammenfassung: AVT sind häufiger als erwartet und oft klinisch stumm. Phlebitiden, die in Verbindung mit einer Venenverweilkanüle auftreten, sollten duplexsonographisch abgeklärt werden. Weitere Studien, insbesondere zur Rolle der oberflächlichen, katheterassoziierten Phlebitiden, wären wünschenswert.
Relação entre a violência e a saúde mental das mulheres no Brasil: análise das políticas públicas
Authors: Medeiros Mariana Pedrosa de , Zanello Valeska 
Published: January 2019

A violência de gênero tem sido fortemente associada a prejuízos na saúde mental das mulheres, tais como a configuração de quadros de depressão, ansiedade, fobias, transtorno pós-traumático, suicídio, problemas alimentares, etc. O presente artigo teve como escopo analisar se, e como, as políticas públicas desenvolvidas para as mulheres e aquelas resultantes da Reforma Psiquiátrica dialogam entre si no que tange ao tema dos impactos da violência na saúde mental das mulheres. Para isto, foi realizada uma análise dos três Planos Nacionais de Políticas para as Mulheres (2004-2013), da Lei Maria da Penha (2006) e da Política Nacional de Enfrentamento à Violência contra as Mulheres (2011), das quatro Conferências Nacionais de Saúde Mental (1987-2004) e da Lei da Reforma Psiquiátrica (2001) buscando-se evidenciar as interseccionalidades (in)existentes entre ambas as políticas. A análise demonstrou que o diálogo entre estes documentos ainda é incipiente e a violência de gênero contra as mulheres não tem sido tratada claramente como um fator de risco para a saúde mental. Faz-se mister visibilizar esta relação e propor aos serviços de saúde intervenções mais eficazes para lidar com mulheres que foram ou estão sendo vítimas de violência.
Cemento-Osseous dysplasia-related jaw necrosis − a case report and literature review
Authors: Atiea Tasnim , Henien Marianne , Sproat Chris , Thavaraj Selvam , Patel Vinod 
Published: January 2019

Abstract: Osteonecrosis of the jaw (ONJ) is most commonly related to medications such as anti-resorptives and anti-angiogenics or head and neck radiotherapy. However, in addition to these, alternative causes of ONJ have also been reported including; infection, chemical toxicity, trauma and vascular ischaemia, but this list is not exhaustive. It is well accepted that cemento-osseous dysplasia (COD) can increase the risk of infection, poor healing and osteomyelitis due to the reduced vascularity. However, necrotic and exposed COD has not been widely reported. This case report describes a patient with COD-related necrosis in the anterior mandible and hence provides an additional member to the ever growing list of potential predisposing factors for jaw necrosis CPD/Clinical Relevance: Cemento-osseous dysplasia is a well recognized and benign condition commonly diagnosed from radiographs. The condition carries an increased risk of osteomyelitis and slow healing following oral surgery and, at its extreme, can cause osteonecrosis of the jaw, which remains an important condition of which the general dental practitioner (GDP) should be aware.
Loss of vitality in an unrestored, caries-free, lower premolar
Authors: Sangar Taranjit , Bateman Geoff 
Published: January 2019

An apical abscess associated with a caries free and unrestored tooth (virgin tooth) is uncommon. This may present diagnostic challenges and risk in general dental practice. The following report illustrates the diagnostic challenges and the initial management of pain in the case described. CPD/Clinical Relevance: Patients presenting with endodontic pain should be examined carefully, with particular reference to radiographic exposure of suspect teeth. Dentists should come to a presumptive diagnosis only after such careful examination and not make assumptions based on either a tooth of apparent integrity or, alternatively, heavily restored in nature.
An instrument to identify computerised primary care research networks, genetic and disease registries prepared to conduct linked research: TRANSFoRm International Research Readiness (TIRRE) survey
Authors: Jennings Emily , de Lusignan Simon , Michalakidis Georgios , Krause Paul , Sullivan Frank , Liyanage Harshana , Delaney Brendan C. 
Published: January 2019

PurposeThe Translational Research and Patients safety in Europe (TRANSFoRm) project aims to integrate primary care with clinical research whilst improving patient safety. The TRANSFoRm International Research Readiness survey (TIRRE) aims to demonstrate data use through two linked data studies and by identifying clinical data repositories and genetic databases or disease registries prepared to participate in linked research.MethodThe TIRRE survey collects data at micro-, meso- and macro-levels of granularity; to fulfil data, study specific, business, geographical and readiness requirements of potential data providers for the TRANSFoRm demonstration studies. We used descriptive statistics to differentiate between demonstration-study compliant and non-compliant repositories. We only included surveys with >70% of questions answered in our final analysis, reporting the odds ratio (OR) of positive responses associated with a demonstration-study compliant data provider.ResultsWe contacted 531 organisations within the Eurpean Union (EU). Two declined to supply information; 56 made a valid response and a further 26 made a partial response. Of the 56 valid responses, 29 were databases of primary care data, 12 were genetic databases and 15 were cancer registries. The demonstration compliant primary care sites made 2098 positive responses compared with 268 in non-use-case compliant data sources [OR: 4.59, 95% confidence interval (CI): 3.93–5.35, p < 0.008]; for genetic databases: 380:44 (OR: 6.13, 95% CI: 4.25–8.85, p < 0.008) and cancer registries: 553:44 (OR: 5.87, 95% CI: 4.13–8.34, p < 0.008).ConclusionsTIRRE comprehensively assesses the preparedness of data repositories to participate in specific research projects. Multiple contacts about hypothetical participation in research identified few potential sites.
Investigation of Mechanical and Anti-Corrosion Properties of Flame Sprayed Coatings
Authors: Musztyfaga-Staszuk M. , Czupryński A. , Kciuk M. 
Published: January 2019

Abstract
This article presents the results of an examination of the properties of thermal flame sprayed coatings produced by material in the form of four powders (two polymers: PA11 and PA12 CastoPlast, and two high purity: tin and aluminum) on the substrate of the unalloyed structural steel of S235JR grade. Investigations of coating properties are based on metallography tests (SEM and CLSM), measurement of microhardness (acc. to PN-EN ISO 6507-1:2007), anticorrosive (acc. to PN-EN ISO 9227:2017-06) and bend testing. Results demonstrate properties of flame sprayed coatings that are especially promising in the industrial applications where corrosion-resistant coating properties are required. Consequently, performed experiments show that the highest corrosion resistance is demonstrated by steel samples with a polyamide anti-corrosion system. Accelerated corrosion tests showed the lowest corrosion resistance of the tin coating system, however, they do not fully correspond to the corrosion processes in operating conditions.
Estimation of Endostatin level in pulmonary arterial hypertension patients and its relation with some parameters
Authors: Al-Khafaji Khama’al Hussein Abod , Al-Dujaili Mohammed Noori , Al-Dujaili Arshad Noori 
Published: January 2019

Abstract
Biomarkers are attractive non-invasive tools for estimating and monitoring pulmonary arterial hypertension (PAH) disease and for predicting survival in patients with PAH; therefore, many studies encouraged the investigation of new biomarkers to facilitate the diagnosis of PAH. Endostatin (ES) is an endogenous inhibitor of angiogenesis. It is produced by proteolytic cleavage of the collagen XVIII that is present in both normal and cancerous tissue. In vitro examination shows that ES can manage endothelial cells (EC) physiology in ways that could influence angiogenesis. For example, solvent ES hinders EC movement and prompts improvements of the cytoskeleton that incorporate the loss of Actin stretch strands and central grips. This effect embraces restrictions on the α5β1integrins, Tropomyosin, and putative heparan sulfate proteoglycans. Consequences for the human EC cytoskeleton include Es-induced down-regulation of Mitogen-actuated Protein Kinase (MAPK), Focal Adhesion Kinase (FAK), the Urokinase Plasminogen Activator (uPA) System, and the RhoA GTPase. Human ES has likewise been shown in a few investigations to repress EC multiplication. Moreover, ES-instigated cell cycle capture in the G1 stage is joined by Cyclin D1 down-regulation. Of note, ES blocks the proliferation and organization of endothelial cells into new blood vessels, and in animal studies, ES also inhibits angiogenesis and the growth of both primary tumors and secondary metastasis. ES was initially identified by its capacity to inhibit tumor angiogenesis in vitro and also in vivo. It can also be found in both healthy and patient’ serum, and has been detected in peripheral circulation. ES could be an attractive, non-invasive prognostic marker for some diseases, notably PAH. Therefore, the presented work is aimed at investigating the ES level in blood serum as a biomarker for detection, diagnosis and early treatment of PAH patients. In doing so, the association is ascertained between gender, age, body mass index (BMI), waist circumferences, smoking, types of PAH (primary and secondary) and this potential biomarker is assessed in PAH patients.
A comparative study of phenolic compound antioxidant activity by the polarography method, using microsomal lipid peroxidation in vitro
Authors: Gordiienko Anatolii , Blazheyevskyi Mykola , Iurchenko Ivan 
Published: January 2019

Abstract
For comparative purposes, a quantitative estimation of antioxidant activity of phenolic compounds of different classes was conducted by way of the polarography method, via the ADP-Fe2+ model of the induced ascorbate-dependent lipid peroxidation of rat liver micro-somes within an in-vitro system. As a result, it was recognized that the antioxidant properties of phenolic compounds depend on the nature and chemical structure of several substances. In respect of such activity, leaders in the classes of investigated polyphenolic compounds are: Propyl gallate = Gallotannin (Phenolcarboxylic acids and their derivatives) > Quercetin = Myricetin (Flavonols) > Luteolin (Flavo n) = Mangiferin (Xanthones) > Kaempferol (Flavonols) = Catechin (Flavans). Thus, the assessment of the inhibition ability of the lipid peroxidation of microsomes by phenolic compounds can be used as an accessible test for the preliminary quantitative estimation of their antioxidant properties.
Gastric lipomatosis
Authors: Cieszczyk Katarzyna , Pasnik Iwona , Wronecki Lech , Ostrowska Anna , Bojar Pawel , Marzec-Kotarska Barbara , Szumilo Justyna 
Published: January 2019

Abstract
Gastric lipomatosis is a condition characterized by the presence of multiple lipomas or diffuse mature adipose tissue infiltration within the gastric wall. The diffuse form is thought to be an extremely rare, with only few described cases. The lesion may be asymptomatic or associated with symptoms and signs depending on location and size. Treatment depends on clinical presentation, range and complications. In a symptomatic disease, it should be surgical, but conservative treatment is preferred for asymptomatic and solitary lesions. Among diagnostic methods, computed tomography and magnetic resonance imaging are thought to be the most valuable.