bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis on seeking medical treatment delay and influencing factors of tuberculosis patients among students in Wuhan,China during 2012－2023
Authors: Zhang Zhengbin , Quan Chao , Chen Jun , Yu Aiping , Zhang Zefang , Hu Jing , Liao Wanjun , Lu Zhouqin , Chen Guoxi , Zhou Meilan , Wang Xiaojun , Zhang Wei , Wu Gang , Li Yuehua , Wang Jianjie 
Published: November 2024

Abstract

Background
Tuberculosis (TB) treatment delay is one of the major challenges to end tuberculosis in many developing countries. Such cases may contribute to an increased TB transmission and severity of illness.Timely detection and treatment of tuberculosis is an effective means to control tuberculosis especially in school where is a place with dense crowds and strong mobility.This study aims to assess the magnitude of student patient delay in seeking medical treatment and associated factors in Wuhan,China.
Methods
We used the medical record information of PTB patients of students in Wuhan recorded by the National Tuberculosis Management Information System(TBIMS) in 2012-2023,then exported to the Statistical Package for Social Science (SPSS) version 25 to analyze the delay and change trend of seeking medical treatment of student tuberculosis patients, and took Multi-variable logistic regression method to ascertain the factors affecting the delay of seeking medical treatment of students.
Results
The median time of student TB patients in seeking medical treatment was 11 (5,21) days in Wuhan, and 38.54% of involved student TB patients in seeking medical treatment for more than 14 days after onset of their TB symptoms. From 2012 to 2023, except for the year of COVID-19, there was little fluctuation in the delay of students seeking medical treatment for tuberculosis in other years. during COVID།19, the time from symptoms onset to seeking medical treatment was significantly shorter due to the strengthening of school morning and afternoon examinations and symptom screening,the proportion of students aged ≥ 18 seeking medical treatment for tuberculosis is the highest among age groups.The results of multivariate analysis showed that near urban area, female, 13–18years old, ethnic minorities, and follow-up patients were at higher risk of delay in seeking medical treatment, and different ethnic groups and patient sources were the main influencing factors of delay in treatment.
Conclusion
There was a high prevalence of delay in seeking medical treatment among pulmonary tuberculosis (PTB) student patients in Wuhan, nearly 1/4 of student patients experienced the delay of seeking medical treatment. Students from ethnic minorities or abroad, as well as patients from the tracking group were factors associated with delay in seeking medical treatment. Providing health education to the community and more active case tracking by staff in grassroots community health service centers would minimize the delay.
Nitrogen Interaction with Other Nutrients in Sour orange Seedling
Authors: Kargar Farnaz , Mirsoleimani Abbas , Najafi-Ghiri Mahdi 
Published: November 2024

Abstract

Nitrogen is one of the main elements in plant nutrition and its deficiency or toxicity can affect plant performance and the uptake and translocation of other nutrients. In this research, we investigated the effect of different nitrogen (N) concentrations in nutrient solution on morphological, and biochemical characteristics, as well as the absorption and translocation of other nutrients in sour orange seedlings. The results showed that the optimal N concentration to achieve the highest growth is 16 mM, lower concentrations have no significant effect on this, but at 32 mM N it is greatly reduced. By increasing the N concentration in the culture medium from 2 to 16, there was an increase in root dry weight (46%), shoot dry weight (46%), leaf area (24%), root length (27%), total chlorophyll (56%), and Fv/Fm (22%). In 16 mM N, concentration of potassium, calcium, magnesium, iron, manganese, zinc, and copper in the shoot and root calcium concentration increased, while the concentration of magnesium, manganese, zinc, and copper in the shoot decreased. Nitrate toxicity occurred at 32 mM, and caused a decrease in plant dry weight (57%) and nitrate reductase enzyme activity in the root (45%) and shoot (41%), as well as a decrease in translocation of N, potassium, calcium, iron, and copper from roots to shoots. With the increase of N concentration in the growth medium, ratio of calcium to potassium in the plant increased, which should be considered in calcareous soils where the high amount of dissolved calcium prevents the uptake of potassium.
Genome-wide identification, characterization, and expression analysis of BZR transcription factor family in Gerbera hybrida
Authors: Luo Qishan , Huang Gan , Lin Xiaohui , Wang Xiaojing , Wang Yaqin 
Published: November 2024

Abstract

Background: The BZR family genes encode plant-specific transcription factors that serve as pivotal regulators of plant BR signaling pathway, critically influencing plant growth and development.
Results: In this study, we performed a genome-wide investigation of BZR family gene in gerbera in order to identify the key components of BR pathway that may function in petal growth. The identified BZR genes, named GhBEH1-7 (GhBEH1, GhBEH2, GhBEH3, GhBEH4, GhBEH5, GhBEH6, GhBEH7), are distributed across chromosomes 3, 5, 10, 11, 12, 14 and 15. These genes exhibit similar exon-intron structures and possess typical BZR family structure. Phylogenetic analysis clustered these genes into two distinct subgroups. Analysis of cis-acting elementsrevealed their involvement in hormone response, stress response and growth regulation. Subcellular localization analysis indicated nuclear localization for GhBEH1 and GhBEH2, while the remainingfive genes exhibited dual localization in the nucleus and cytoplasm. Transactivation assay indicated GhBEH1 and GhBEH2 may function as transcriptional repressors, contrasting with the transcriptional activation observed for the other five genes. Notably, seven GhBEHs exhibits various expression patterns under different growth stages of ray florets and BR treatment conditions. While, GhBEH1 and GhBEH2showed pronounced responsiveness to BR stimulation.
Conclusion: Our work explains genome-wide identification, characterization, and expression analysis of BZR transcription factor family in gerbera, and hinted these seven GhBEHs is involved in regulating petal growth and development. These findings provide a basis for further studies on further research on the biological function of the BZR gene family in petal growth and a theoretical basis for future horticultural application in gerbera.
Effect of differences in precision vascular anatomy on surgical outcomes of distal pancreatectomy: a retrospective study
Authors: Fukada Masahiro , Mitsui Noriki , Horaguchi Takeshi , Hatanaka Yuji , Yasufuku Itaru , Sato Yuta , Tajima Jesse Yu , Kiyama Shigeru , Tanaka Yoshihiro , Murase Katsutoshi , Matsuhashi Nobuhisa 
Published: November 2024

Abstract

Background
Minimally invasive distal pancreatectomy (MIDP) is increasingly performed worldwide; therefore, a better understanding of precision vascular anatomy during surgery is important. However, the effect of differences in precision vascular anatomy on surgical outcomes remains unclear. This study aimed to evaluate the effect of precision vascular anatomical variations on surgical outcomes and identify factors that influence open and minimally invasive surgery (MIS) outcomes.
Methods
This was a single-center retrospective study involving 123 patients who underwent distal pancreatectomy (DP). We analyzed the correlation between precision anatomical variations, namely, (i) the root of the splenic artery (SpA; type 1 and type 2), (ii) the parent artery of the dorsal pancreatic artery, (iii) confluence patterns of the left gastric vein, and (iv) the inferior mesenteric vein and surgical outcomes. We also performed a risk analysis of prolonged operation time, considering surgery-related factors.
Results
SpA type 2 was only significantly associated with longer operation time (p < 0.01) in DP procedures. In all DP cases, the pancreatic resection line (above the portal vein: odds ratio [OR] 3.47; 95% confidence interval [CI] 1.69–11.18; p < 0.01), SpA type (type 2; OR 2.77; 95% CI 1.16–6.94; p = 0.02), and surgery type (MIS; OR 5.24; 95% CI 2.17–14.00; p < 0.001) were independently associated with prolonged operation times. In open-DP cases, high body mass index (> 24; OR 7.24; 95% CI 1.89–36.34; p < 0.01), tumor location (pancreatic body; OR 6.89; 95% CI 1.79–33.79; p < 0.01), and SpA type (type 2; OR 5.86; 95% CI 1.72–24.65; p < 0.01) showed significant association with prolonged operations. In MIDP cases, sex (male; OR 9.07; 95% CI 2.61–38.65; p < 0.001) and the pancreatic resection line (above the portal vein; OR 4.12; 95% CI 1.18–17.08; p = 0.03) showed significant associations.
Conclusions
SpA type 2 may affect surgical outcomes negatively. Therefore, recognizing and approaching precision vascular anatomy appropriately are important. MIS may be effective in mitigating the negative effects of variations in precision vascular anatomy.
All-optical Loss-tolerant Distributed Quantum Sensing
Authors: Nehra Rajveer , Oh Changhun , Jiang Liang , Marandi Alireza 
Published: November 2024

Abstract

Distributed quantum sensing (DQS) leverages quantum resources to estimate an unknown global property of a networked quantum sensor beyond the classical limit. We propose and analyze an all-optical resource-efficient scheme for the next-generation DQS systems.
Our method utilizes phase-sensitive optical parametric amplifiers (OPAs) and linear interferometers and achieves the sensitivity close to the optimal limit, as determined by the quantum Fisher information of the entangled resource state. Furthermore, it utilizes high-gain OPA-assisted detection, offering critical advantages of increased bandwidth and loss tolerance, in contrast to conventional methods employing balanced homodyne detection (BHD). We show the efficacy of our proposal for displacement sensing and show its loss tolerance against high levels of photon loss, thus circumventing the major obstacle in current BHD-based approaches. Our architectural analysis shows that our scheme can be realized with current quantum photonic technology.
Toxicological evaluation of some antidepressant drugs on carbonic anhydrase isoenzymes (hCA I, hCA II), acetylcholinesterase and butyrylcholinesterase enzymes activitiy: an in vitro and in slico study
Authors: İşgör Mehmet Mustafa , Turkan Fikret , Huyut Zübeyir , Karaman Muhammet 
Published: November 2024

Abstract

Depression is a common and serious medical illness that adversely affects the person how they feel, how they think and behave. Some common antidepressant drugs were investigated in the study. The effects of these drugs on carbonic anhydrases 1 and 2 enzymes, glutathione S-transferase, acetylcholine esterase and butyrylcholine esterase enzymes were investigated. The study was carried out in in vitro conditions. The toxicological effects of drugs were interpreted as inhibition values of enzymes. IC50 values were calculated first by inhibition studies. Then Ki values were calculated for all enzymes. hCA I, h CA II enzymes Ki value was found in Maprotiline as 6.57 ± 0.5 and 4.15 ± 0.11. It was found in Imipramine for AChE and BChE enzymes 0.8 ± 0.14, 3.58 ± 0.21 with values of Ki. Binding affinities were calculated as -7.624kcal/mol and − 5.850kcal/mol for best-poses of Maprotiline hCA I and hCA II and as -9.864 kcal/mol and − 9.317 kcal/mol for best-poses of Imipramine-AChE and BChE, respectively. 2 N-methyl- propylamine and N, N-dimethyl- propylamine moieties have played an essential role for inhibition of the enzymes.
Enabling solid sample analysis in liquid spectrophotometers with a 3d-printed cuvette
Authors: Kono Junichiro , Doumani Jacques , Mansfield Henry , Baydin Andrey , Sasmal Somesh , Tahchi Mario El , Gao Weilu 
Published: November 2024

Abstract

Most commercial systems for ultraviolet-visible (UV-VIS), Fourier-transform infrared, circular dichroism (CD), and fluorescence spectroscopies are designed for measurement of liquid samples. Moreover, adapters enabling the measurement of solid samples are expensive or unavailable for most commercial instruments. Consequently, there is a significant need for solid sample adapters that enable measurement of both liquid and solid samples with a single system. Here, we report two versions of a solid sample adapter cuvette that can be used in most commercial spectroscopy instruments designed for liquid samples. One version is designed for techniques that do not require changing the sample orientation, and the other allows easy sample rotation. We successfully fabricated these cuvettes by 3D printing with both fused deposition modeling and stereolithography and demonstrated how they enable us to study the optical properties of macroscopic films of aligned carbon nanotubes by performing UV-VIS and CD spectroscopy measurements with the cuvettes. These 3D printed cuvettes and their implementation will help enable a wide range of experiments at a low cost.
ANCA-Negative Eosinophilic Granulomatosis And Polyangiitis With An Underlying CMV Enteritis Leading To Small Bowel Perforation- A Case Report and Literature Review
Authors: Barjas Haidar , Alkhatib Mohammed , Alqalalwah Adalah , Obiedat Sarah , Eldean Mouhammad Sharaf , Elzouki Abdel-Nasser 
Published: November 2024

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a form of vasculitis that involves the small to medium-sized blood vessels. It can be an ANCA positive or negative disease. EPGA can affect virtually any organ system with the most predominant system being the respiratory system, however, gastrointestinal tract involvement has been reported in a minority of patients. We report a young pleasant gentleman who initially presented with a bout of gastroenteritis and eosinophilia where further investigations showed evidence of vasculitis and the hospital course was complicated by cardiac ischemic event and small bowel perforation mandated resecting a segment of the small bowel surgically. Histopathology of the resected small bowel showed evidence of vasculitis with eosinophilic infiltration and extensive Cytomegalovirus (CMV) infection which could be the main underlying culprit behind bowel perforation.
Effects of seedling nursery lifespan and pot size on growth and survival rate of Grevillea robusta,in .Eastern Amhara
Authors: Alemu Andualem Ayalew , Ayalew Gezahagn Getachew , Mengistie Hodaddis Kassahun , Sisay Derbie Wudu , Menber Gebeyehu Alamrie , Alle Tigabu Redae , Ayene Muluken Wudu 
Published: November 2024

Abstract

Gravellia robusta is selected for study due to a prominent priority and potential species for plantation, rehabilitation of degraded lands and agroforestry purposes, given its ecological and economic significance. The research aimed to investigate the effect of different seedling nursery life span (4, 5, and 6 months) and different pot size (8cm, 10cm, and 12cm) influence growth parameters of G.robusta. Root length, shoot length, and the ratio of root length to shoot length were measured in the nursery, whereas root collar diameter, diameter at breast height, height, and survival rate, volume and MAI were encompassed in the field. The experiment was conducted using a randomized complete block design in both nursery and field. The data were analyzed using R software version 4.3.2. Results revealed significant effects of pot size and nursery life span at p < 0.05 in terms of shoot length in the nursery which has implication for the presence of large root length in the nursery. The study concludes that, for mid-altitude regions, pot sizes and nursery life spans do not significantly affect the growth and survival of G.robusta. It would be beneficial to study further how longer months affect the growth and survival rate of G.robusta seedlings in order to clarify the effects of longer months.
Moral Distress and Compassion Fatigue Among Healthcare Workers During the COVID-19 Pandemic: The Moderating Role of Organizational Support
Authors: Quan Xin , Li Pei-Fen , Burnett Christopher 
Published: November 2024

Abstract

The COVID-19 pandemic has put healthcare workers in various morally distressful situations while undertaking demanding tasks of providing needed care for patients. Research has shown that moral distress could lead to long-lasting negative physiological and psychological consequences among healthcare workers and worsened job retention among healthcare organizations (Corley et al., 2001, Morley, 2018). Studies have reported mental health outcomes such as anxiety, depression, burnout, posttraumatic stress disorder, and compassion fatigue that resulted from moral distress during the COVID-19 pandemic (Norman et al., 2021, Whitehead et al., 2021). This study filled the gap in the literature by employing Lazarus and Folkman’s (1984) transactional theory of stress and coping to investigate how moral distressful events create stressful outcomes and how coping resources mitigate the negative impacts. Structural equation modeling was used to perform a moderated mediation analysis of study variables. The result of this study supported the mediating role of moral distress in the relationship between morally distressful event and compassion fatigue, and the moderating role of organizational support in the relationship between morally distressful event and moral distress. These findings suggested developing effective interventions to mitigate the negative impacts of moral distressful events for healthcare workers during and after the COVID-19 pandemic.
Effect of bariatric surgery on TSH levels and levothyroxine dosage in patients with thyroid disease
Authors: Camastra Stefania , Patrizio Armando , Palumbo Maria Anna , Astiarraga Brenno , Redi Giacomo , Moretto Carlo , Bellini Rosario , Antonelli Alessandro 
Published: November 2024

Abstract

Objectives
Bariatric surgery might impact on the thyroid function test and, in hypothyroid patients, the dose of levothyroxine (LT4), but data are not univocal. We examined the change of thyroid function in the first year after bariatric surgery in euthyroid patients and in patients with thyroid disease on LT4 comparing the effects of Roux-en-Y gastric bypass (RYGB) vs sleeve gastrectomy (SG).
Methods
The data was collected from medical records of hospitalization of 235 patients (104 SG and 131 RYGB) who underwent pre-surgical work-up and from outpatient medical records of the same patients at 45 days, 3–6 months and 1-year visits after surgery. In the final analysis we included 69 patients on LT4 therapy (43 Tr-RYGB and 26 Tr-SG) and 85 patients without thyroid diseases with normal thyroid function (48 Ct-RYGB and 37 Ct-SG), who served as matched controls.
Results
The mean body weight reduction for al cohort was in 31.4 ± 0.7% after 1 year from the surgery. In the two Nt groups, TSH levels remained stable throughout the observation period, without differences for type of surgery and without relationship with body weight. After bariatric surgery, the patients treated with LT4, belonging to both Tr-RYGB and Tr-SG, needed to increase the dosage per body weight to achieve stable TSH. At 1 year, the increase of LT4/kg/die was higher in the Tr-RYGB group than Tr-SG group (0.44 vs 0.30 mcg/kg/die, p = 0.032).
Conclusions
In patients with severe obesity and normal thyroid function, TSH levels are not related to body weight change. Patients treated with LT4, after bariatric surgery need to increase the dosage pro kg of body weight of the LT4 and the increase is higher after surgery with malabsorptive component (RYGB) compared to restrictive surgery (SG).
Comparison of Different Maintenance Treatments Options for Newly Diagnosed BRCAwt Advanced Ovarian Cancer: A Retrospective Cohort Analysis
Authors: Chen Xi , Fang Chenyan , Guo Yanglong , Zhang Yingli 
Published: November 2024

Abstract

Introduction:
Niraparib and bevacizumab are the two major maintenance treatment options for newly diagnosed advanced ovarian cancer (AOC) cases with BRCA wild-type (BRCAwt), irrespective of HRD status. Furthermore, there are a considerable number of BRCAwt ovarian cancer patients with unknown HRD status in China. The goal of this study was to compare niraparib and bevacizumab for maintenance therapy.
Methods
Retrospective data were collected for newly diagnosed BRCAwt AOC patients who underwent niraparib or bevacizumab maintenance treatment. Progression free survival (PFS) was examined and propensity score matching (PSM) to adjust for potential differences in baseline patient characteristics in both cohorts.
Results
Overall, 103 patients were enrolled, with 60 administered niraparib and 43 treated with bevacizumab. Patients administered bevacizumab showed a slightly higher risk of relapse than niraparib group, with higher proportion of stage IV (53.49% vs. 30.00%) and partial response rate after chemotherapy (40.48% vs. 13.33%). Median PFS (mPFS) was not reached [NR (95% CI 26.94-NR)] after niraparib treatment, vs. 13.77 months (95% CI 8.51–24.44) in the bevacizumab group (HR = 0.247, p < 0.0001). After adjustment for baseline patient characteristics by PSM, 33 patients were analyzed in each cohort. mPFS after PSM was still longer with niraparib [NR (95% CI 19.55-NR)] than bevacizumab [18.30 months (HR = 0.360, 95% CI 8.90-25.26; p = 0.005).
Conclusion
This analysis showed that niraparib confers enhanced survival benefits than bevacizumab in BRCAwt AOC with or without baseline modification. Both therapeutic regimens were well-tolerated in the real-world setting. This work provides an important reference for maintenance treatment in BRCAwt AOC patients with unknown HRD status.
Management And outcome of prosthetic valve obstruction: A Single-Center Experience
Authors: Tolah Majed , Alharbi Ibraheem H , Sandogj Hasan , abdelrehim Ayman , Lami Nouf , Alkhalaf Thekra , Fallatah Baraa , Utuanis Shyelene , shabaan Ahmed 
Published: November 2024

Abstract

Background
Obstructive prosthetic valve thrombosis is a life-threatening complication associated with high morbidity and mortality. Evaluation of outcomes of surgical management and identification of the perioperative variables associated with poor prognosis is necessary to provide appropriate interventions.
Results
We conducted a retrospective analysis of 39 patients who underwent redo surgery for obstructive prosthetic valve at the Madinah Cardiac Center, Saudi Arabia. Between January 2017 to October 2023 Preoperative, intraoperative, and postoperative factors that influenced the outcome were analyzed. The nature of the obstructed valve was commonly mechanical (32/39, 82.1%) located in the mitral position (30/39, 76.9%). Occurred due to thrombosis and the size of the thrombus was more than 1 cm in 27 (69.2%) patients. A high percentage (25/39, 64.1%) of the patients had a suboptimal INR (less than 2). The major postoperative complications were respiratory failure (6/39, 15.4%) and dysrhythmias (20/39, 51.3%). The 30-day post operative mortality was 7.7% (3/39). Patients who underwent surgery after failed thrombolysis had significantly higher mortality than those who underwent direct surgery (p = 0.018).
Conclusion
Prosthetic valve thrombosis is primarily associated with suboptimal anticoagulant therapy and can occur years after valve replacement surgery. The prognosis for redo valve replacement is favorable .with a 30-day operative mortality rate of 7.7%. For patients with prosthetic valve thrombosis, Direct surgical intervention without prior fibrinolysis may be safe and effective for patients with prosthetic valve thrombosis .