bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Prepectoral Implant Placement and Complete Coverage with TiLoop Bra Mesh for Breast Reconstruction: A Prospective Study on Long-Term and Patient-Reported BREAST-Q Outcomes
Authors: Casella Donato , Di Taranto Giuseppe , Marcasciano Marco , Sordi Silvia , Kothari Ashutosh , Kovacs Tibor , Lo Torto Federico , Cigna Emanuele , Calabrese Claudio , Ribuffo Diego 
Published: October 2018

Background:
Breast reconstruction is rapidly evolving, because of the changing face of cancer surgery and the growing acceptance of acellular dermal matrices and synthetic meshes. Although some early reports showed encouraging results after prepectoral breast reconstruction, there is a paucity of data on long-term outcomes.

Methods:
Between January of 2012 and March of 2015, 179 patients undergoing mastectomy were enrolled at the authors’ institution. Patients underwent mastectomy and immediate prepectoral breast reconstruction with the definitive implant entirely wrapped in a titanium-coated polypropylene mesh (TiLoop). The BREAST-Q questionnaire was administered before surgery and after 2 years. Capsular contracture was evaluated using the Baker scale. Oncologic, surgical, and aesthetic outcomes and changes in BREAST-Q score were analyzed over time.

Results:
Average follow-up was 38.5 months. A total of 250 mastectomies were performed. The locoregional recurrence rate was 2.1 percent. Complications requiring reoperation were recorded in six patients (2.4 percent) and implant removal was necessary in three cases (1.2 percent), followed by reconstruction with submuscular expanders. Grade IV capsular contracture was detected in five breasts (2 percent), whereas 212 breasts were evaluated as grade I (84.8 percent), 28 breasts as grade II (11.2 percent), and five breasts as grade III (2 percent). Patients reported significant high rates in the BREAST-Q overall Satisfaction with Outcome (73.8), overall Satisfaction with Breasts (72.5), Psychosocial Well-being (77.7), and Sexual Well-being (57.9), scoring a significant increase in these domains from the preoperative period to the postoperative period (p < 0.05).

Conclusion:
The authors report encouraging results of a prepectoral direct-to-implant reconstruction technique using a synthetic mesh, supporting the evaluation of the muscle-sparing subcutaneous approach as a valid alternative to traditional submuscular reconstruction.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.
Single-incision Laparoscopy Versus Multiport Laparoscopy for Colonic Surgery
Authors: Maggiori Léon , Tuech Jean Jacques , Cotte Eddy , Lelong Bernard , Denost Quentin , Karoui Mehdi , Vicaut Eric , Panis Yves 
Published: October 2018

Objective:
To compare outcome of single-port laparoscopy (SPL) and multiport laparoscopy (MPL) laparoscopy for colonic surgery.

Summary of Background Data:
Benefits of SPL over MPL are yet to be demonstrated in large randomized trials.

Methods:
In this prospective, double-blinded, superiority trial, patients undergoing laparoscopic colonic resection for benign or malignant disease were randomly assigned to SPL or MPL (NCT01959087). Primary outcome was length of theoretical hospital stay (LHS).

Results:
One hundred twenty-eight patients were randomized and 125 analyzed: 62 SPL and 63 MPL, including 91 right (SPL: n = 44, 71%; MPL: n = 47, 75%) and 34 left (SPL: n = 18, 29%; MPL: n = 16, 25%) colectomies, performed for Crohn disease (n = 53, 42%), cancer (n = 36, 29%), diverticulitis (n = 21, 17%), or benign neoplasia (n = 15, 12%). Additional port insertion was required in 5 (8%) SPL patients and conversion to laparotomy occurred in 7 patients (SPL: n = 3, 5%; MPL: n = 4, 7%; P = 1.000). Total length of skin incision was significantly shorter in the SPL group [SPL: 56 ± 41 (range, 30–300) mm; MPL: 87 ± 40 (50–250) mm; P < 0.001]. Procedure duration, intraoperative complication rate, postoperative 30-day morbidity, postoperative pain, and time to first bowel movement were similar between the groups, leading to similar theoretical LHS (SPL: 6 ± 3 days; MPL: 6 ± 2; P = 0.298). At 6 months, quality of life was similar between groups, but patients from the SPL group were significantly more satisfied with their scar aspect than patients from the MPL group (P = 0.003).

Conclusion:
SPL colectomy does not confer any additional benefit other than cosmetic result, as compared to MPL.
Clinical Validation of the Comprehensive Complication Index as a Measure of Postoperative Morbidity at a Surgical Department
Authors: de la Plaza Llamas Roberto , Ramia Ángel José M. , Bellón Juan M. , Arteaga Peralta Vladimir , García Amador Cristina , López Marcano Aylhín J. , Medina Velasco Aníbal A. , González Sierra Begoña , Manuel Vázquez Alba 
Published: October 2018

Objective:
Using clinical outcomes, to validate the comprehensive complication index (CCI) as a measure of postoperative morbidity in all patients undergoing surgery at a general surgery department.

Background:
The Clavien-Dindo classification (CDC) is the most widely used system to assess postoperative morbidity. The CCI is a numerical scale based on the CDC. Once validated, it could be used universally to establish and compare the real postoperative complications of each surgical procedure.

Methods:
Observational prospective cohort study. All patients who underwent surgery during the 1-year study period were included. All the complications graded with the CDC and related to the initial admission, or until discharge if the patient was readmitted within 90 days of surgery, were included. Surgical procedures were classified according to the operative severity score (OSS) as minor, moderate, major, or major+. The clinical validation of the CCI was performed by assessing its correlation with 4 different clinical outcomes.

Results:
A total of 1850 patients were included: 513 (27.7%) presented complications and 101 (5.46%) were readmitted. In the multivariate analysis, the CCI and CDC were associated with postoperative stay, prolongation of postoperative stay, readmission, and disability in all OSS groups (P < 0.001). The CCI was superior to the CDC in all models except for prolongation of stay for OSS moderate and major+.

Conclusions:
The CCI can be applied in all the procedures carried out at general surgery departments. It is able to determine the morbidity and allows the comparison of the outcomes at different services.
Altered orbitofrontal sulcogyral patterns in gambling disorder: a multicenter study
Authors: Li Yansong , Wang Zixiang , Boileau Isabelle , Dreher Jean-Claude , Gelskov Sofie , Genauck Alexander , Joutsa Juho , Kaasinen Valtteri , Perales José , Romanczuk-Seiferth Nina , de Lara Cristian M Ruiz , Siebner Hartwig R , van Holst Ruth J , van Timmeren Tim , Sescousse Guillaume 
Published: October 2018

AbstractGambling disorder is a serious psychiatric condition characterized by decision-making and reward processing impairments that are associated with dysfunctional brain activity in the orbitofrontal cortex (OFC). However, it remains unclear whether OFC functional abnormalities in gambling disorder are accompanied by structural abnormalities. We addressed this question by examining the organization of sulci and gyri in the OFC. This organization is in place very early and stable across life, such that OFC sulcogyral patterns (classified into Type I, II and III) can be regarded as potential pre-morbid markers of pathological conditions. We gathered structural brain data from nine existing studies, reaching a total of 165 individuals with gambling disorder and 159 healthy controls. Our results, supported by both frequentist and Bayesian statistics, show that the distribution of OFC sulcogyral patterns is skewed in individuals with gambling disorder, with an increased prevalence of Type II pattern compared with healthy controls. Examination of gambling severity did not reveal any significant relationship between OFC sulcogyral patterns and disease severity. Altogether, our results provide evidence for a skewed distribution of OFC sulcogyral patterns in gambling disorder, and suggest that pattern Type II might represent a pre-morbid structural brain marker of the disease. It will be important to investigate more closely the functional implications of these structural abnormalities in future work.
Lateral Asymmetry in Weekly Reproducibility of Resting State Amygdala Functional Connectivity
Authors: Tetereva Alina , Balaev Vladislav , Kartashov Sergey , Ushakov Vadim , Ivanitsky Alexey , Martynova Olga 
Published: October 2018

AbstractAbnormal functional connectivity of the amygdala with several other brain regions has been observed in patients with higher anxiety or post-traumatic stress disorder, both in a resting state and threatening conditions. However, findings on the specific connections of the amygdala might be varied due to temporal and individual fluctuations in the resting state functional connectivity (rsFC) of the amygdala and its lateral asymmetry, as well as possible variability in anxiety among healthy subjects. We studied reproducibility of rsFC data for the right and left amygdala, obtained by functional magnetic resonance imaging twice in a one-week interval in 20 healthy volunteers with low to moderate anxiety. We found resting-state amygdala network, which included not only areas involved in the emotion circuit, but regions of the default mode network (DMN) associated with memory and other brain areas involved in motor inhibition and emotion suppression. The amygdala network was stable in time and within subjects, but between-session reproducibility was asymmetrical for the right and left amygdala rsFC. The right amygdala had more significant connections with DMN regions and the right ventrolateral prefrontal cortex. The rsFC values of the right amygdala were more sustained across the week than the left amygdala rsFC. Our results support a hypothesis of functional lateralization of the amygdala. The left amygdala is more responsible for the conscious processing of threats, which may produce more variable rsFC; the right amygdala rsFC is more stable due to its greater engagement in continuous automatic evaluation of stimuli.HighlightsAmygdala resting state network included areas of emotion circuit and motor controlDuring rest amygdala was functionally connected with areas of default mode networkFunctional connectivity of the right amygdala was more sustained across the weekFunctional connections of amygdala network were more stable in the right hemisphere
Thalamic state influences timing precision in the thalamocortical circuit
Authors: Whitmire Clarissa J , Liew Yi Juin , Stanley Garrett B 
Published: October 2018

AbstractSensory signals from the outside world are transduced at the periphery, passing through thalamus before reaching cortex, ultimately giving rise to the sensory representations that enable us to perceive the world. The thalamocortical circuit is particularly sensitive to the temporal precision of thalamic spiking due to highly convergent synaptic connectivity. Thalamic neurons can exhibit burst and tonic modes of firing that strongly influence timing within the thalamus. The impact of these changes in thalamic state on sensory encoding in the cortex, however, remains unclear. Here, we investigated the role of thalamic state on timing in the thalamocortical circuit of the vibrissa pathway in the anesthetized rat. We optogenetically hyperpolarized thalamus while recording single unit activity in both thalamus and cortex. Tonic spike triggered analysis revealed temporally precise thalamic spiking that was locked to white-noise sensory stimuli, while thalamic burst spiking was associated with a loss in stimulus-locked temporal precision. These thalamic state dependent changes propagated to cortex such that the cortical timing precision was diminished during the hyperpolarized (burst biased) thalamic state. While still sensory driven, the cortical neurons became significantly less precisely locked to the white-noise stimulus. The results here suggest that tonic thalamic spiking is more temporally precise than burst firing, which leads to distinct differences in sensory information representation at the level of both the thalamus and the cortex, as assessed using spike triggered analysis. This difference in spike timing precision enables a dynamic encoding scheme for sensory information as a function of thalamic state.New and NoteworthyThe majority of sensory signals are transmitted through the thalamus. There is growing evidence of complex thalamic gating through coordinated firing modes that have a strong impact on cortical sensory representations. Optogenetic hyperpolarization of thalamus pushed it into burst firing that disrupted precise time-locked sensory signaling, with a direct impact on the downstream cortical encoding, setting the stage for a timing-based thalamic gate of sensory signaling.
Difference equation−based transient-state and steady-state analysis of flyback converter circuit
Authors: Yener Namik , Yildiz Ali Bekir 
Published: October 2018

Purpose
This paper aims to present how to use the difference equations for analysis of flyback converter circuit.

Design/methodology/approach
Switching circuits have variable structural topologies. In every switched-mode, they have different dynamics and different equations. First, the exact equivalent circuit of flyback converter, then, set of difference equations are obtained. The flyback converter has a nonlinear structure; however, the presented technique allows the circuit equations to be linear. The transient-state and steady-state analysis of flyback converter, one of popular switching circuits, are carried out by using difference-equations.

Findings
The proposed analysis method does not contain any numerical approximation and the results are in the form of exact solution. Another superiority of the method is that the desired instantaneous values can be obtained directly, the simulation does not need to be started from the beginning. Numerical results agree well with the theoretical results of flyback converter. The simulation results obtained by using the proposed method and Matlab-based results are compared.

Originality/value
This paper contributes a different mathematical background for analysis of switching converters to the literature.
Quality of teachers in technical higher education institutions in India
Authors: Sharma Payal , Pandher Jagwinder Singh 
Published: October 2018

Purpose
The quality of education depends upon the quality of teachers, i.e. professional competence. The purpose of this paper is to empirically identify the state of faculty’s quality in technical higher education institutions of Punjab (India) in terms of their competences. Later, differences in the quality of the faculty of both public (government funded) and private (partially or not funded by government) technical institutions were examined.

Design/methodology/approach
In total, 35 technical institutes were selected to conduct a field survey and total 594 respondents including teachers, students and administrators had responded to the present study from different departments of engineering and management. The state of faculty’s quality in terms of their competences has been examined through confirmatory factor analysis in AMOS 20.0. Discriminant analysis in SPSS 20.0 has been performed to find the differences in faculty of both the public and private sectors.

Findings
This paper provides a broader picture of the poor quality of teachers in technical institutions of Punjab (India) in terms of lacking most of the competencies. The study also reveals significant differences in the faculty of both public and private sector institutes in terms of select competences.

Originality/value
This paper demonstrates an alarming stage of poor-quality state of teachers. Therefore, educational administrators and policy makers need to show their concern for the improvement of teachers’ quality in technical higher education institutions of Punjab (India).
Knowledge sharing serves as a mediator between collaborative culture and innovation capability: an empirical research
Authors: Yang Zhi , Nguyen Van Thithuy , Le Phong Ba 
Published: October 2018

PurposeThis paper aims to investigate the correlation between collaborative culture, knowledge sharing and innovation capabilities in Chinese firms.Design/methodology/approachThis paper used structural equation modeling to examine the level of how collaborative culture and knowledge sharing impact on two types of innovation capabilities (product innovation and process innovation) based on using data collected from 77 Chinese firms.FindingsThe research findings show that knowledge sharing plays a mediating role between collaborative culture and two specific types of innovation, namely, product innovation and process innovation. The paper first confirms the moderating role of ownership form in the relationships between knowledge sharing and innovation capabilities. The results underline the necessity of building a collaborative culture to stimulate employees’ knowledge sharing behavior, which in turn positively promotes innovation capabilities in an organization.Research limitations/implicationsThe paper has not evaluated the relationship between latent variables under the condition of moderating variables of individual characteristics (such as optimism and self-efficacy) or firm characteristics (such as industry type, firm size and firm age). Further research should examine the moderating effects of these variables to have clearer relationship between the constructs.Practical implicationsThis paper offers leaders a deeper understanding of the effects of ownership forms and potential factors to promote innovation capabilities in their firms.Originality/valueThe paper has contributed to theoretical and practical initiatives on the theory of innovation management which enable firms to identify the necessary factors and mechanism to enhance firm capabilities for innovation.
A psychoacoustical approach to resolving office noise distraction
Authors: Oseland Nigel , Hodsman Paige 
Published: October 2018

Purpose
The purpose of this paper is to determine whether noise is affected by psychological factors rather than simply by physical metrics. For example, personality type, age, perceived control and screening ability were explored, as well as the choice of primary workplace.

Design/methodology/approach
An online survey was conducted which resulted in 517 valid responses. The survey included the personality profiling along with questions related to noise and personal circumstances. The key noise metrics were perceived performance, ability to work, well-being and stress plus three noise indices: concentration, distraction and speech interference.

Findings
The survey revealed that personality type does affect noise perception, in particular extroversion and neuroticism. Perceived control, screening ability, age, workplace, design and focused work are also factors. Personal variables accounted for 25 per cent of the variance in the ability to carry out work, and for 40 per cent of the variance in concentration and speech interference.

Research limitations/implications
Whilst statistically significant differences were found for most of the psychological and personal variables, the size of effect was smaller than anticipated. This is likely because the survey was carried out across a range or workplaces, rather than in a laboratory, with a number of uncontrolled extraneous factors.

Practical implications
The research has resulted in the development of a design guidance document for controlling noise distractions based on more psychoacoustic, people-centred, principles than purely physical ones.

Originality value
Most acoustics research is conducted in the laboratory and focuses on the physical sound properties. This research took a psychoacoustic approach focusing more on psychological and personal factors, and was carried out in the real world.
Key factors in the engineering process for systems for aging in place contributing to low usability and success
Authors: Hallewell Haslwanter Jean D. , Fitzpatrick Geraldine , Miesenberger Klaus 
Published: October 2018

Purpose
Digital systems for independent aging, support and care are not being adopted as hoped. The purpose of this paper is to examine the results of three studies to derive key factors during the development and engineering process of care and support systems for older people that can impact acceptance and uptake to provide support to future projects.

Design/methodology/approach
The paper analyzed the results of three qualitative studies, including two detailed case studies and a further study with 35 participants, to derive key factors. Methods for deriving factors are based on thematic analysis to identify common factors across cases and participants.

Findings
The findings point to a broad set of interconnected factors that give developers of these types of systems specific recommendations. These highlight what makes these projects complex and identify implications for the development process. Furthermore, they show way the needed user-centered and iterative methods may be in conflict with funding processes.

Originality/value
While others have reported on single projects or looked at acceptance, these studies were the first to explore aspects of the development process that may contribute to the lack of success to date of these types of systems. The results here support more successful outcomes in the future, both by helping people involved in the development of these systems to avoid some of the issues others face and providing input to improve the performance of the engineering process.
Biological properties in relation to health promotion effects of Garcinia mangostana (queen of fruit)
Authors: Karim Naymul , Tangpong Jitbanjong 
Published: October 2018

Purpose
For the prevention and cure of disease, patient use various types of chemical and drug agents. Along with their curative effect, almost all drugs have some destructive effects and side-effects. Due to the minimal and/or none of unwanted side-effect, recently, the use of herbal remedy as the drug of choice becomes the preference choice. The mangosteen, Garcinia mangostana, contains various types of polyphenols. It has been used as a traditional medicine from the ancient times till present days. The purpose of this paper is to investigate the biological properties of mangosteen in relation to health promotion effects.

Design/methodology/approach
Several research papers from well-known database (such as PubMed, Google scholar, Scopus and Sciencedirect) were reviewed without considering publication-times to understand the biological properties of mangosteen.

Findings
Mangosteen and its xanthone exerted diverse biological activities such as anti-oxidant, anti-inflammatory, anti-allergy, anti-bacteria, anti-fungal, anti-malaria, anticancer and anti-diabetes.

Originality/value
Based on these studies, mangosteen is beneficial dietary supplement of overall human health.