bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inferring Meaning From Meaningful Parts: The Contributions of Morphological Skills to the Development of Children's Reading Comprehension
Authors: Levesque Kyle C. , Kieffer Michael J. , Deacon S. Hélène 
Published: June 2018

AbstractSkilled reading comprehension is an important goal of educational instruction and models of reading development. In this study, the authors investigated how core skills surrounding morphemes, that is, the minimal units of meaning in language, support the development of reading comprehension. The authors specifically contrast the roles of morphological awareness and morphological analysis; the first refers to the awareness of and ability to manipulate morphemes in language, and the second refers to the use of morphemes in inferring the meaning of unfamiliar morphologically complex (multimorphemic) words. The authors evaluated these morphological skills in 197 English‐speaking students who were followed from grade 3 to grade 4; the analyses used stringent autoregressor controls to home in on predictors of gains over time. In addition to morphological awareness and morphological analysis, the authors assessed students' reading comprehension and controls for word reading, vocabulary, phonological awareness, nonverbal ability, and age. Multivariate autoregressive path analysis revealed that morphological analysis, but not morphological awareness, predicted gains in reading comprehension. Morphological awareness, for its part, predicted gains in morphological analysis. Taken together, the findings allude to a developmental trajectory whereby students' use of morphemes to infer the meanings of unfamiliar complex words supports the development of reading comprehension over time. The development of this skill, in turn, appears to be supported by a more general awareness of morphemes in language. These findings contribute to theory and reading instruction by clarifying the ways in which morphological skills support the development of students' reading comprehension.
Social Bonds for Sustainable Development: A Human Rights Perspective on Impact Investing
Authors: PARK Stephen Kim 
Published: June 2018

AbstractThis article analyses the human rights implications of impact investing, which aims to create positive social and environmental impacts in addition to financial returns. Reflecting growing awareness of the capacity of the global capital markets to advance sustainable development, companies and institutional investors are seeking new financial instruments and strategies. This article focuses on social bonds, a prominent and illuminating example of this phenomenon. Social bonds are debt securities sold to investors whose proceeds are used to finance projects with a defined social benefit such as affordable housing, education, food security, and access to healthcare. To analyse social bonds in the context of human rights, this article proposes a framework for evaluating human rights factors in impact investing and applies it to the social bond market. It finds that current standards and practices do not adequately account for the human rights implications of social bonds. In light of these observations, this article suggests reforms to the social bond market that enhance investor assessment, external assurance, and impact-maximizing leverage.
FRONTIER, FORTIFICATION, AND FORESTATION: DEFENSIVE WOODLAND ON THE SONG–LIAO BORDER IN THE LONG ELEVENTH CENTURY
Authors: Chen Yuan Julian 
Published: June 2018

ABSTRACTThis article examines the creation, preservation, and destruction of the defensive forest that the Northern Song built in Hebei along the Song–Liao border. Created as a landscape barrier against the Kitan attacks, this forest established the necessary strategic depth between the capital city and the northern frontline of the Song empire to compensate for Kaifeng's geographical vulnerability. While the Song government painstakingly maintained this forest throughout most of the dynasty, Liao troops, Hebei borderland residents, and many Song officials had nonetheless posed incessant challenges to this military forestation project. In 1122/23, at the onset of the war on the Liao to retrieve the Sixteen Prefectures, the Song army removed this borderland forest that blocked their northern expedition. The destruction of this defensive forest, which could have had thwarted attacks from the north, dismantled the strategic depth between Kaifeng and the Hebei borderland and henceforth presaged the fall of Kaifeng to the Jin, the Liao's successor, in a few years. I argue that this strategic depth was not only a physical distance, but also a diplomatic, sociopolitical, and military link that connected the ecology of the Song's northernmost periphery and the fate of the entire empire.
Cricopharyngeal achalasia associated with laryngomalacia as a cause of failure to thrive
Authors: Givens V , Brent K , Dunham M , Kanotra S P 
Published: June 2018

AbstractObjectiveTo describe a case of concurrent cricopharyngeal achalasia with laryngomalacia as a cause of failure to thrive, and to review the literature and management options of cricopharyngeal achalasia in the paediatric population.MethodsA chart review was performed on a four-month-old male, referred for failure to thrive, and diagnosed with cricopharyngeal achalasia and laryngomalacia. A PubMed and Embase search for ‘cricopharyngeal achalasia’ and ‘laryngomalacia’ was conducted. A review of reported paediatric cricopharyngeal achalasia patients, with emphasis on management options, was undertaken.ResultsA flexible laryngoscopic examination confirmed the laryngomalacia diagnosis, and videofluoroscopic evaluation of swallowing demonstrated cricopharyngeal achalasia via a cricopharyngeal bar. Supraglottoplasty was performed, with botulinum toxin injection into the cricopharyngeus muscle, with resultant improvement in oral intake and resolution of failure to thrive. The literature review revealed no reported case of the combined pathologies as a cause of failure to thrive.ConclusionFunctional endoscopic evaluation of swallowing and videofluoroscopic evaluation of swallowing are complimentary in the evaluation of paediatric patients with failure to thrive and suspected oropharyngeal dysphagia. Both supraglottoplasty and botulinum toxin injection are effective for definitive management in cases of combined pathology, and can be safely performed in a single surgical setting.
Public Authority and Local Resistance: Abdur Rehman and the industrial workers of Lahore, 1969–1974
Authors: MALIK ANUSHAY 
Published: June 2018

AbstractIn 1968 a popular movement emerged on the streets of Pakistan which toppled the regime of General Muhammad Ayub Khan and ushered in the Pakistan People's Party (PPP). After a decade of military rule this movement was heralded as a turning point in the country's political fortunes. However, the war in 1971, the failure of the PPP to live up to its radical slogans, and Pakistan's eventual return to military rule in 1977 were seen as clear indications of the failure of both the movement and the PPP. This article focuses on the area of Kot Lakhpat in Lahore and the emergence of a worker-led court under Abdur Rehman to argue that this narrative of the failure of the movement does not leave space for local success stories which, while temporary, had an important impact on the role that the working classes imagined for themselves within the state. The Kot Lakhpat movement was part of a longer history of labour politics, and its story challenges the centrality of the PPP and shows how local structures of authority can be formed in response to the greater space for radical action opened up by a wider national resistance movement.
Good job, good pension? The influence of the workplace on saving for retirement
Authors: Robertson-Rose Lynne 
Published: June 2018

AbstractMost private-sector employees in the United Kingdom (UK) are automatically enrolled into individualised defined contribution (DC) pension accounts. In a DC environment, income adequacy in retirement is highly dependent on the decisions that individuals make earlier in their lives. The ease with which they move into employment, and the pension support that they then receive from their employer, can be critical in determining outcomes. This paper discusses how employees respond to workplace pension schemes and the circumstances under which they assess the suitability of their contributions. The findings are based on an embedded case study comprising qualitative interviews with 25 employees of a large UK utility company. Participants were selected on the basis of socio-economic similarity. The research concluded that fixed-term employment negatively impacted on saving for retirement, both with respect to scheme membership and to the level of saving. Furthermore, it was found that the employment context had an influence upon retirement savings behaviour. The proactive approach of the employer in providing retirement benefits, and the trust that employees had in their employer, positively influenced membership and contribution levels. In addition to employer endorsement effects, both the encouragement of older work colleagues and workplace norms had a role to play in influencing how successfully individuals prepared for retirement.
Dermatofibrosarcoma protruberans of the scalp treated with customised surface mould high-dose-rate (HDR) brachytherapy: a case report
Authors: Bandyopadhyay Anis , Basu Poulami , Biswas Somrita , Ghosh Sandip 
Published: June 2018

AbstractDermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive soft tissue tumor commonly occurring in the trunk or extremities, lesser than 5% being located on the scalp. Surgery is the mainstay of management of this locally infiltrative cutaneous soft tissue sarcoma, with a high probability of recurrence if margin remains positive or inadequate. Adjuvant radiotherapy to a dose of 40–60 Gy decreases this chance of recurrence considerably. Radiotherapy is generally delivered by interstitial HDR brachytherapy, opposed photon or electron beam. We report a case of a 24 year old female, presenting with a small, painless nodule over right frontal area of scalp, diagnosed as DFSP post surgery with close margin that was treated with adjuvant radiation customized HDR surface mould brachytherapy with good local control and cosmesis.
The design of pension contracts: on the perspective of customers
Authors: Mei Zhaoxun 
Published: June 2018

AbstractThis paper introduces a new pension contract which provides a smoothed return for the customer. The new contract protects customers from adverse asset price movements while keeping the potential of positive returns. It has a transparent structure and clear distribution rule, which can be easily understood by the customer. We compare the new contract to two other contracts under Cumulative Prospect Theory (CPT); one has a similar product structure but without guarantees and the other provides the same guarantee rate but with a different structure. The results show that the new contract is the most attractive contract for a CPT-maximising customer. Yet, we find different results if we let the customer be an Expected Utility Theory-maximising one. Moreover, this paper presents the static optimal portfolio for an individual customer. The results conform to the traditional pension advice that young people should invest more of their money in risky assets while older people should put more money in less risky assets.
Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success
Authors: Kelleher Andrew M. , Milano-Foster Jessica , Behura Susanta K. , Spencer Thomas E. 
Published: June 2018

AbstractUterine glands are essential for pregnancy establishment. By employing forkhead box A2 (FOXA2)-deficient mouse models coupled with leukemia inhibitory factor (LIF) repletion, we reveal definitive roles of uterine glands in embryo implantation and stromal cell decidualization. Here we report that LIF from the uterine glands initiates embryo-uterine communication, leading to embryo attachment and stromal cell decidualization. Detailed histological and molecular analyses discovered that implantation crypt formation does not involve uterine glands, but removal of the luminal epithelium is delayed and subsequent decidualization fails in LIF-replaced glandless but not gland-containing FOXA2-deficient mice. Adverse ripple effects of those dysregulated events in the glandless uterus result in embryo resorption and pregnancy failure. These studies provide evidence that uterine glands synchronize embryo-endometrial interactions, coordinate on-time embryo implantation, and impact stromal cell decidualization, thereby ensuring embryo viability, placental growth, and pregnancy success.
Formal enantioconvergent substitution of alkyl halides via catalytic asymmetric photoredox radical coupling
Authors: Li Jiangtao , Kong Manman , Qiao Baokun , Lee Richmond , Zhao Xiaowei , Jiang Zhiyong 
Published: June 2018

AbstractClassic nucleophilic substitution reactions (SN1 and SN2) are not generally amenable to the enantioselective variants that use simple and racemic alkyl halide electrophiles. The merging of transition metal catalysis and radical chemistry with organometallic nucleophiles is a versatile method for addressing this limitation. Here, we report that visible light-driven catalytic asymmetric photoredox radical coupling can act as a complementary and generic strategy for the enantioconvergent formal substitution of alkyl haldies with readily available and bench-stable organic molecules. Single-electron reductive debrominations of racemic α-bromoketones generate achiral alkyl radicals that can participate in asymmetric Csp3–Csp3 bonds forming cross-coupling reactions with α-amino radicals derived from N-aryl amino acids. A wide range of valuable enantiomerically pure β2- and β2,2-amino ketones were obtained in satisfactory yields with good-to-excellent enantioselectivities by using chiral phosphoric acid catalysts to control the stereochemistry and chemoselectivity. Fluoro-hetero-quaternary and full-carbon quaternary stereocenters that are challenging to prepare were successfully constructed.
Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP
Authors: Subramanian Hariharan , Froese Alexander , Jönsson Peter , Schmidt Hannes , Gorelik Julia , Nikolaev Viacheslav O. 
Published: June 2018

AbstractNatriuretic peptides (NPs) are important hormones that regulate multiple cellular functions including cardiovascular physiology. In the heart, two natriuretic peptide receptors NPR1 and NPR2 act as membrane guanylyl cyclases to produce 3′,5′-cyclic guanosine monophosphate (cGMP). Although both receptors protect from cardiac hypertrophy, their effects on contractility are markedly different, from little effect (NPR1) to pronounced negative inotropic and positive lusitropic responses (NPR2) with unclear underlying mechanisms. Here we use a scanning ion conductance microscopy (SICM) approach combined with Förster resonance energy transfer (FRET)-based cGMP biosensors to show that whereas NPR2 is uniformly localised on the cardiomyocyte membrane, functional NPR1 receptors are found exclusively in membrane invaginations called transverse (T)-tubules. This leads to far-reaching CNP/NPR2/cGMP signals, whereas ANP/NPR1/cGMP signals are highly confined to T-tubular microdomains by local pools of phosphodiesterase 2. This provides a previously unrecognised molecular basis for clearly distinct functional effects engaged by different cGMP producing membrane receptors.
Cracking effects in squashable and stretchable thin metal films on PDMS for flexible microsystems and electronics
Authors: Baëtens Tiffany , Pallecchi Emiliano , Thomy Vincent , Arscott Steve 
Published: June 2018

AbstractHere, we study cracking of nanometre and sub-nanometre-thick metal lines (titanium, nickel, chromium, and gold) evaporated onto commercial polydimethylsiloxane (PDMS) substrates. Mechanical and electromechanical testing reveals potentially technologically useful effects by harnessing cracking. When the thin film metal lines are subjected to uniaxial longitudinal stretching, strain-induced cracks develop in the film. The regularity of the cracking is seen to depend on the applied longitudinal strain and film thickness—the findings suggest ordering and the possibility of creating metal mesas on flexible substrates without the necessity of lithography and etching. When the metal lines are aligned transversally to the direction of the applied strain, a Poisson effect-induced electrical ‘self-healing’ can be observed in the films. The Poisson effect causes process-induced cracks to short circuit, resulting in the lines being electrically conducting up to very high strains (~40%). Finally, cracking results in the observation of an enhanced transversal gauge factor which is ~50 times larger than the geometric gauge factor for continuous metal films—suggesting the possibility of high-sensitivity thin-film metal strain gauge flexible technology working up to high strains.
Function of Thelenota ananas saponin desulfated holothurin A in modulating cholesterol metabolism
Authors: Han Qi-an , Li Kaifeng , Dong Xiuping , Luo Yongkang , Zhu Beiwei 
Published: June 2018

AbstractThis work was designed to separate and purify the saponin from Thelenota ananas with the highest anti-cholesterol ability using multiple chromatography and mass spectrometry analyses, and to systematically investigate the effect of the Thelenota ananas saponin on cholesterol metabolism in oxidized low-density lipoprotein (ox-LDL) induced macrophage foam cells. Desulfated holothurin A (desHA), which was finally identified as the targeted saponin with the highest activity in decreasing low-density lipoprotein-cholesterol (LDL-C), markedly inhibited the formation of foam cells derived from macrophages based on Oil Red O staining. In addition, desHA significantly blocked the synthesis of fatty acid synthetase while promoted intracellular cholesterol efflux. Furthermore, desHA inhibited the effects of ox-LDL on macrophage mRNA expression, which enhanced the level of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoAR) and suppressed the expression of SR-BI, ABCA1 and ABCG1, which further increased the levels of extracellular cholesterol and triglyceride. Blocking AKT and AMPK pathway and LXR synthesis revealed that desHA also regulated the contents of HMG-CoAR and eNOS via LXR/AKT/AMPK pathway. Thus, desHA played an essential role in cholesterol efflux and synthesis, which indicated desHA and Thelenota ananas are valuable resources to exploit new functional food and nutraceuticals.
Moderate fabrication and characterization of the microcrystalline Sr2CuO3 glass films with effective nonlinearities
Authors: Xu Tao , Hu Guangcai , Jiang Jutao , Yin Congfei , Xiang Run , Liang Xiaojuan , Xiang Weidong 
Published: June 2018

AbstractSince nonlinear optical materials used in the ultrafast all-optical switching is an important part for the modern optical technology, cuprates have been widely investigated for their specific Cu-O chain structure and intriguing optical properties. We present a new preparation method of microcrystalline Sr2CuO3 glass films on glass substrates combining spin-coating and co-sintering techniques. Then, the as-prepared samples were polished for different times to obtain microcrystalline Sr2CuO3 glass films with varying thickness. The influence of polishing time on the structure, the valence state and the nonlinear optical response were discussed, respectively. The purity of the Sr2CuO3 phase, surface morphology and the chemical composites of these synthesized glass films were given with scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). Importantly, optical absorption spectroscopy and Z-scan technique were used to measure linear absorption and third-order optical nonlinearity of the films. The experiments showed that third-order nonlinear susceptibility of the 140 min polished film sample with a thickness of 18 μm was up to 1.23 × 10−12 esu, indicating its potential application in the nonlinear field.
Hemostasis in the Very Young
Authors: Barg Assaf , Nowak-Göttl Ulrike , Kenet Gili 
Published: June 2018

AbstractHemostasis is a dynamic process that starts in utero. The coagulation system evolves with age, as evidenced by marked physiological differences in the concentration of the majority of hemostatic proteins in early life compared with adulthood. This concept, known as “developmental hemostasis,” has important biological and clinical implications. Overall, impaired platelet function, along with physiologically reduced levels of vitamin K–dependent and contact coagulation factors, may cause poorer clot firmness even in healthy neonates. However, increased activity of von Willebrand factor and low levels of coagulation inhibitors that promote hemostasis counterbalance the delicate and immature hemostatic system. Since this hemostatic system has little reserve capacity, preterm neonates or sick infants are extremely vulnerable and predisposed to either hemorrhagic or thrombotic complications. This review will address the concept and manifestations of developmental hemostasis with respect to clinical disease phenotypes. It will discuss bleeding diagnosis in neonates, dealing especially with the devastating complications of intracerebral and pulmonary hemorrhage in preterm infants. Neonates, especially the sickest preterm ones, are also extremely susceptible to thrombotic complications; thus, thrombosis in neonates will be reviewed, with special focus on arterial ischemic perinatal stroke. Based on the concept of developmental hemostasis, the phenotypes of clinically relevant bleeding or thrombotic disorders among neonates may differ from those of older infants and children. Treatment options for these conditions will be suggested and reviewed.
The future of the philosophy of religion is the philosophy of culture—and vice versa
Authors: Grimshaw Mike 
Published: June 2018

AbstractThis paper reads the future of the Philosophy of Religion via a critical engagement with the thought of Paul Tillich and diversions into other thinkers to support the main thrust of the argument. It takes as a starting point Tillich’s discussion of the relationship between religion and culture inOn the Boundary(1967), in particular his statement “As religion is the substance of culture, culture is the form of religion” (69–70). With (unlikely) diversions via TS Eliot and Karl Barth, the argument is developed through a re-reading of Tillich’s work on a theology of culture and in particular the statement fromSystematic Theology III(1964b) that “…religion cannot express itself even in a meaningful silence without culture, from which it takes all forms of meaningful expression. And we must restate that culture loses its depth and inexhaustibility without the ultimacy of the ultimate” (264). Central to the rethinking of this paper is then the reworking of Tillich’s statement inOn the Boundarythat “My philosophy of religion …consciously remains on the boundary between theology and philosophy, taking care not to lose the one in the other. It attempts to express the experience of the abyss in philosophical concepts and the idea of justification as the limitation of philosophy” (52). While this can be seen as expressing the basis of continental philosophy and its creative tension between theology and philosophy, this paper inserts culture as the meeting point that holds theology and philosophy in tension and not opposition. That is, a theology of culture also engages with a philosophy of culture; just as a philosophy of religion must engage with a philosophy of culture; for it is culture that gives rise to both theology and philosophy, being the place where they both meet and distinguish themselves. The final part of this paper articulates a rethought Philosophy of Culture as the boundary space from which the future of the Philosophy of Religion can be thought, in creative tension with a Tillich-derived radical theology.