bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controlled Synthesis of the FeB Nanometallic Glasses with Stronger Electron Donating Capability to Activate Molecular Oxygen for the Enhanced Ferroptosis Therapy
Authors: Shi Gongyu , Zhang Yongxuan , Wang Wenting , Xiang Wanxuan , Zhang Feng , Zhu Xiaojiao , Zhou Hongping 
Published: December 2024

AbstractConsidering the strong electron‐donating ability and the superior biocompatibility, the integration of zero‐valent iron nanostructure Fe0 (electron‐reservoir) and zero‐valent boron nanostructure B0 offers great promise for fabricating novel ferroptosis nanoagents. Nevertheless, the controlled and facile synthesis of alloyed Fe0 and B0 nanostructure‐FeB nanometallic glasses (NMGs) has remained a long‐standing challenge. Herein, a complexion‐reduction strategy is proposed for the controlled synthesis of FeB NMGs with greater electron donating capacity to activate the molecular oxygen for improved ferroptosis therapy. In‐depth mechanism reveales that the complexion‐reduction strategy effectively prevent the long‐range diffusion of Fe0, resulting in the amorphous alloyed Fe0 and B0 nanostructure‐FeB nanoparticles (FeB NPs). The FeB NPs display stronger electron donating capability and electron transfer rate 9.4 times higher than that of the Fe0 NPs, which effectively activate the molecular oxygen to produce ∙O2
−, H2O2 and ∙OH. The in vitro cellular experiments confirm the FeB‐ss‐SiO₂ NPs (encapsulation with SiO2 outlayer containing ‐S‐S‐ bonds) demonstrates the enhanced ferroptosis. The tumor‐bearing mice models shows that FeB‐ss‐SiO₂ NPs exhibited superior biocompatibility and tumor inhibition effect (inhibition rate of 73%), which improve the overall survival rate for 30 days post‐treatment. This study will provide an innovative way to design therapeutic nanoagents for cancer treatments.
Sulfasalazine‐Loaded Copper‐Tannic Acid Coordination Nanozyme Enables ROS Scavenging and Immunomodulation for Inflammatory Bowel Disease Therapy
Authors: Yan Jian‐Hua , Liang Chun‐Xiao , Ma Ran‐Ran , Li Bo‐Jia , Chen Qi‐Wen , Li Wen , Zeng Xuan , Zhang Xian‐Zheng 
Published: December 2024

AbstractInflammatory bowel disease (IBD) is associated with elevated levels of reactive oxygen species (ROS) and an increased expression of proinflammatory cytokines. Anti‐inflammatory drugs, monoclonal antibodies, and immunomodulators are commonly employed to control the inflammatory response in the management of IBD. Here, a copper and tannic acid (TA) coordination nanozyme (CuTA) loaded with sulfasalazine (SSZ‐CuTA) is synthesized for the treatment of IBD by simultaneous scavenging ROS and immunosuppression. The CuTA exhibits both dismutase‐like activity and catalase‐like activity, making it efficient at scavenging ROS. These nanozymes can efficiently traverse gastric acid and subsequently exert their effects within the intestinal tract. It is verified that SSZ‐CuTA can restore intestinal mucosal and goblet cells to a healthy state by effectively eliminating ROS and reducing the pro‐inflammatory factors in a mouse IBD model. Overall, the SSZ‐CuTA will offer a promising alternative treatment for patients suffering from IBD where excessive ROS and high inflammation coexist.
Integrating 3D Bioprinting and Organoids to Better Recapitulate the Complexity of Cellular Microenvironments for Tissue Engineering
Authors: Hu Yan , Zhu Tong , Cui Haitao , Cui Haijun 
Published: December 2024

AbstractOrganoids, with their capacity to mimic the structures and functions of human organs, have gained significant attention for simulating human pathophysiology and have been extensively investigated in the recent past. Additionally, 3D bioprinting, as an emerging bio‐additive manufacturing technology, offers the potential for constructing heterogeneous cellular microenvironments, thereby promoting advancements in organoid research. In this review, the latest developments in 3D bioprinting technologies aimed at enhancing organoid engineering are introduced. The commonly used bioprinting methods and materials for organoids, with a particular emphasis on the potential advantages of combining 3D bioprinting with organoids are summarized. These advantages include achieving high cell concentrations to form large cellular aggregates, precise deposition of building blocks to create organoids with complex structures and functions, and automation and high throughput to ensure reproducibility and standardization in organoid culture. Furthermore, this review provides an overview of relevant studies from recent years and discusses the current limitations and prospects for future development.
Ba/Ti MOF: A Versatile Heterogeneous Photoredox Catalyst for Visible‐Light Metallaphotocatalysis
Authors: Muralirajan Krishnamoorthy , Khan Il Son , Garzon‐Tovar Luis , Kancherla Rajesh , Kolobov Nikita , Dikhtiarenko Alla , Almalki Maram , Shkurenko Aleksander , Rendón‐Patiño Alejandra , Guillerm Vincent , Le Khoa N. , Shterk Genrikh , Zhang Huabin , Hendon Christopher H. , Eddaoudi Mohamed , Gascon Jorge , Rueping Magnus 
Published: December 2024

AbstractThe field of sustainable heterogeneous catalysis is evolving rapidly, with a strong emphasis on developing catalysts that enhance efficiency. Among various heterogeneous photocatalysts, metal‐organic frameworks (MOFs) have gained significant attention for their exceptional performance in photocatalytic reactions. In this context, contrary to the conventional homogeneous iridium or ruthenium‐based photocatalysts, which face significant challenges in terms of availability, cost, scalability, and recyclability, a new Ba/Ti MOF (ACM‐4) is developed as a heterogeneous catalyst that can mimic/outperform the conventional photocatalysts, offering a more sustainable solution for efficient chemical processes. Its redox potential and triplet energy are comparable to or higher than the conventional catalysts, organic dyes, and metal semiconductors, enabling its use in both electron transfer and energy transfer applications. It facilitates a broad range of coupling reactions involving pharmaceuticals, agrochemicals, and natural products, and is compatible with various transition metals such as nickel, copper, cobalt, and palladium as co‐catalysts. The effectiveness of the ACM‐4 as a photocatalyst is supported by comprehensive material studies, photophysical, and recycling experiments. These significant findings underscore the potential of ACM‐4 as a highly versatile and cost‐effective photoredox catalyst, providing a sustainable, one‐material solution for efficient chemical processes.
Sustainable Silk Fibroin Ionic Touch Screens for Flexible Biodegradable Electronics with Integrated AI and IoT Functionality
Authors: Ye Chao , Zhang Hao , Yang Yunhao , Shan Yicheng , Fu Junhao , Gao Wenli , Ren Jing , Cao Leitao , Ling Shengjie 
Published: December 2024

AbstractThe increasing prevalence of electronic devices has led to a significant rise in electronic waste (e‐waste), necessitating the development of sustainable materials for flexible electronics. In this study, silk fibroin ionic touch screen (SFITS) is introduced, a new platform integrating natural silk fibroin (SF) with ionic conductors to create highly elastic, environmentally stable, and multifunctional touch interfaces. Through a humidity‐induced crystallization strategy, the molecular structure of SF is precisely controlled to achieve a balanced combination of mechanical strength, electrical conductivity, and biodegradability. The assembly and operational reliability of SFITS are demonstrated under various environmental conditions, along with their reusability through green recycling methods. Additionally, the intelligent design and application of SFITS are explored by incorporating Internet of Things (IoT) and artificial intelligence (AI) technologies. This integration enables real‐time touch sensing, handwriting recognition, and advanced human‐computer interactions. The versatility of SFITS is further exemplified through applications in remote control systems, molecular model generation, and virtual reality interfaces. The findings highlight the potential of sustainable ionic conductors in next‐generation flexible electronics, offering a path toward greener and more intelligent device designs.
Temperature‐Controlled Dearomative [5+1] Spiroannulation and Formal [5+2] Cyclization of Indoles with Enynones: Divergent Synthesis of Spiro‐Indolenines and Dihydrocyclohepta[b]Indolones
Authors: Dong Bin , Li Zhiming , Li Wei , Deng Jiang , Yan Junyuan , Guo Yihan , Wang Kai‐Kai , Qian Shan , Wang Zhouyu , He Xiao‐Long 
Published: December 2024

AbstractWe developed a temperature‐controlled intermolecular dearomative [5+1] spiroannulation and [5+2] cyclization of indoles with enynones, smoothly delivering a variety of spiroindolenines and dihydrocyclohepta[b]indolones under 40 °C and 80 °C, respectively. A three‐step cascade reaction was also realized by using OTBS or NHBoc containing enynones in the reaction with the indole under the identical condition. And a novel valuable highly‐oriented three‐dimensional indole‐based tetracyclic scaffold was produced in high yields with excellent diastereoselectivities. Additionally, various spiroindolines and spirooxindoles were facilely produced through simple operations. This highly efficient domino‐reaction represents an emblematic method for the preparation of indole‐based polycycles through the intermolecular pathway.
Solar‐Driven Hydrogen Peroxide Production via BiVO4‐Based Photocatalysts
Authors: Tan Hui Ling , Chai Casandra Hui Teng , Heng Jerry Zhi Xiong , Thi Quyen Vu , Wu Xuelian , Ng Yun Hau , Ye Enyi 
Published: December 2024

AbstractSolar hydrogen peroxide (H2O2) production has garnered increased research interest owing to its safety, cost‐effectiveness, environmental friendliness, and sustainability. The synthesis of H2O2 relies mainly on renewable resources such as water, oxygen, and solar energy, resulting in minimal waste. Bismuth vanadate (BiVO4) stands out among various oxide semiconductors for selective H2O2 production under visible light via direct two‐electron oxygen reduction reaction (ORR) and two‐electron water oxidation reaction (WOR) pathways. Significant advancements have been achieved using BiVO4‐based materials in solar H2O2 production over the last decade. This review explores advancements in BiVO4‐based photocatalysts for H2O2 production, focusing on photocatalytic powder suspension (PS) and photoelectrochemical (PEC) systems, representing the main approaches for heterogenous artificial photosynthesis. An overview of fundamental principles, performance assessment methodologies, photocatalyst and photoelectrode development, and optimization of reaction conditions is provided. While diverse strategies, such as heterojunction, doping, crystal facet engineering, cocatalyst loading, and surface passivation, have proven effective in enhancing H2O2 generation, this review offers insights into their similar and distinct implementations within the PS and PEC systems. The challenges and future prospects in this field are also discussed to facilitate the rational design of high‐performing BiVO4‐based photocatalysts and photoelectrodes for H2O2 generation under visible light.
Orbitronics: Mechanisms, Materials and Devices
Authors: Wang Ping , Chen Feng , Yang Yuhe , Hu Shuai , Li Yue , Wang Wenhong , Zhang Delin , Jiang Yong 
Published: December 2024

AbstractSpintronics has been extensively explored over the past decades, focusing primarily on the spin characteristic of the electron, while the orbital feature of the electron has been conventionally assumed to be quenched by the crystal field effect. Recently, studies have unveiled a fascinating discovery that orbital current, originating from orbital effects, can be generated in materials with weak spin‐orbit coupling by applying electric fields, enabling the manipulation of the ferromagnetic magnetization and induction of terahertz emission. This review highlights recent achievements in orbital effects, materials, and devices, beginning by discussing the mechanisms underlying orbital effects, e.g. the orbital Hall effect, orbital Rashba‐Edelstein effect, inverse orbital Hall effect, and inverse orbital Rashba‐Edelstein effect. Subsequently, a wide range of materials exhibiting orbital effects are classified and the orbital sources in them are identified. Furthermore, the review introduces the orbital torque devices and the orbital terahertz emitters, summarizing the in‐depth mechanisms of the orbital torque, orbital torque efficiency, and orbital diffusion length across various material structures. Additionally, the review presents strategies for enhancing orbital torque efficiency and driving magnetization switching. These efforts aim to explore the potential applications for orbitronic memory devices, computing components, and terahertz emitters.
Extension Doping with Low‐Resistance Contacts for P‐Type Monolayer WSe2 Field‐Effect Transistors
Authors: Chen Sihan , Zhang Yue , King William P. , Bashir Rashid , van der Zande Arend M. 
Published: December 2024

AbstractSource/Drain extension doping is crucial for minimizing the series resistance of the ungated channel and reducing the contact resistance of field‐effect transistors (FETs) in complementary metal–oxide–semiconductor (CMOS) technology. 2D semiconductors, such as MoS2 and WSe2, are promising channel materials for beyond‐silicon CMOS. A key challenge is to achieve extension doping for 2D monolayer FETs without damaging the atomically thin material. This work demonstrates extension doping with low‐resistance contacts for monolayer WSe2 p‐FETs. Self‐limiting oxidation transforms a bilayer WSe2 into a hetero‐bilayer of a high‐work‐function WOxSey on a monolayer WSe2. Then, damage‐free nanolithography defines an undoped nano‐channel, preserving the high on‐current of WOxSey‐doped FETs while significantly improving their on/off ratio. The insertion of an amorphous WOxSey interlayer under the contacts achieves record‐low contact resistances for monolayer WSe2 over a hole density range of 1012 to 1013 cm−2 (1.2 ± 0.3 kΩ µm at 1013 cm−2). The WOxSey‐doped extension exhibits a sheet resistance as low as 10 ± 1 kΩ □−1. Monolayer WSe2 p‐FETs with sub‐50 nm channel lengths reach a maximum drain current of 154 µA µm−1 with an on/off ratio of 107–108. These results define strategies for nanometer‐scale selective‐area doping in 2D FETs and other 2D architectures.
Stable Hydrogen‐Bonded Cobalt‐porphyrin Framework for High‐Performance Electrochemical Detection of Carcinoembryonic Antigen
Authors: Wang Youfa , Han Jie , Waterhouse Geoffrey I. N. , Gu Huiwen , Wang Rui , Wu Shuang , Dong Pengfei , Raghavan Vijaya , Wang Jin 
Published: December 2024

ABSTRACTThe accurate and sensitive detection of low‐abundance cancer‐related biomarkers in blood remains a key technical challenge in clinical applications. Herein, a simple and accurate sandwich‐type electrochemical immunosensor based on a stable hydrogen‐bonded cobalt‐porphyrin framework (Co‐HOF) was successfully developed for the ultrasensitive detection of the cancer‐related biomarker, carcinoembryonic antigen (CEA). The antibody‐modified Co‐HOF forms a sandwich structure with the CEA aptamer electrode exclusively in the presence of CEA, enabling the specific electrochemical detection of CEA. The electrochemical signal increased linearly with the concentration of CEA, demonstrating a wide linear range (0.001–50 ng mL−1) and a low detection limit (0.22 pg mL−1), surpassing the performance of commercial ELISA kits and most reported detection methods. The sensor was successfully employed for CEA detection in spiked human serum, with recoveries ranging from 85.04% to 105.20%. Additionally, we collected blood samples from colorectal cancer patients and healthy individuals to clinically validate the sensor, observing that CEA levels increased with cancer progression. The sensor detection results showed strong consistency (R2 = 0.995) with those obtained from commercial ELISA kits, demonstrating the proposed sensor's practicality for clinical detection of CEA and related cancer biomarkers.
On the Stability of Metastable Monomers to Bias the Supramolecular Polymerization of Naphthalendiimides
Authors: Rey‐Tarrío Francisco , Sánchez Luis 
Published: December 2024

AbstractHerein, we report the synthesis of the naphthalendiimides (NDIs) 1–3 endowed with peripheral 3,4,5‐trialkoxybenzamide units and a variable number of 1,2,3‐triazole rings. Both the benzamide units and the triazole rings are able to form six‐ or seven‐membered intramolecularly H‐bonded pseudocycles that behave as metastable monomeric units. Whilst freshly prepared solutions of 1–3 afford H‐type aggregates, the presence or lack of the 1,2,3‐triazole rings strongly conditions the kinetics and stability of the resulting aggregated species. These structural features result in highly stable metastable monomeric species M* for the symmetric 2 that can be trapped for long periods of time when the sample is subject to a heating/cooling cycle. Contrary to NDI 2, the M* species formed by 1 and 3 evolve to the final supramolecular polymers in shorter times. A detailed experimental and theoretical study display the different non‐covalent supramolecular forces operating in the stabilization of such M* species. In all cases, but especially in those NDIs endowed with the triazoles rings (NDIs 2 and 3), a number of conformers for the metastable monomeric units can be modelled. The high stability of such monomeric species justifies the delay in the formation of the H‐type aggregates.
Coulombic Condensation of Liquefied Gas Electrolytes for Li Metal Batteries at Ambient Pressure
Authors: Yin Yijie , Holoubek John , Kim Kangwoon , Liu Alex , Bhamwala Bhargav , Wang Shen , Lu Bingyu , Yu Kunpeng , Gao Hongpeng , Li Mingqian , Raghavendran Ganesh , Cai Guorui , Li Weikang , Liu Ping , Meng Ying Shirley , Chen Zheng 
Published: December 2024

AbstractThe concept of employing highly concentrated electrolytes has been widely incorporated into electrolyte design, due to their enhanced Li‐metal passivation and oxidative stability compared to their diluted counterparts. However, issues such as high viscosity and sub‐optimal wettability, compromise their suitability for commercialization. In this study, we present a highly concentrated dimethyl ether‐based electrolyte that appears as a liquid phase at ambient conditions via Li+ ‐ solvents ion‐dipole interactions (Coulombic condensation). Unlike conventional high salt concentration ether‐based electrolytes, it demonstrates enhanced transport properties and fluidity. The anion‐rich solvation structure also contributes to the formation of a LiF‐rich salt‐derived solid electrolyte interphase, facilitating stable Li metal cycling for over 1000 cycles at 0.5 mA cm−2, 1 mAh cm−2 condition. When combined with a sulfurized polyacrylonitrile (SPAN) electrode, the electrolyte effectively reduces the polysulfide shuttling effect and ensures stable performance across a range of charging currents, up to 6 mA cm−2. This research underscores a promising strategy for developing an anion‐rich, high concentration ether electrolyte with decreased viscosity, which supports a Li metal anode with exceptional temperature durability and rapid charging capabilities.
Evolution of Interfacial Hydration Structure Induced by Ion Condensation and Correlation Effects
Authors: Li Han , Xu Zhi , Li Jiacheng , Siria Alessandro , Ma Ming 
Published: December 2024

AbstractInterfacial hydration structures are crucial in wide‐ranging applications, including battery, colloid, lubrication. Multivalent ions like Mg2+ and La3+ show irreplaceable roles in these applications, which are hypothesized due to their unique interfacial hydration structures. However, this hypothesis lacks experimental supports. Here, we provide the first observation for their interfacial hydration structures with molecular resolution using atomic force microscopy. We observed the evolution of layered hydration structures at La(NO3)3 solution‐mica interfaces. As concentration increases from 25 mM to 2 M, the layer number varies from 2 to 1 and back to 2, and the interlayer thickness rises from 0.25±0.05 to 0.34±0.03 nm, with hydration force increasing from 0.27±0.07 to 1.04±0.24 nN. Theory and molecular simulation reveal that the cations form inner‐sphere complexes. Multivalence induces concentration‐dependent ion condensation and correlation effects, resulting in compositional and structural evolution within interfacial hydration structures. Additional experiments at seven different solid–liquid interfaces together with literature comparison confirm the universality of this mechanism for both multivalent and monovalent ions. New factors affecting interfacial hydration structures are revealed, including concentration and solvent dielectric constant. This insight provides guidance for designing interfacial hydration structures to optimize solid–liquid‐interphase for battery life extension, modulate colloid stability and develop efficient lubricants.
High‑Temperature Image Pre‐Processing Based on ε‐Ga2O3 Photo‐Synapses
Authors: Lin Yingtong , Zhu Yuhan , Wang Feng , Cai Yuchen , Li Zhengqiao , Li Shuhui , Zhan Xueying , He Jun , Jiang Chao , Wang Zhenxing 
Published: December 2024

AbstractThe era of big data has brought about substantial challenges in terms of power consumption and communication bandwidth. Edge‐based neuromorphic computing with data pre‐processing can help alleviate these burdens and enhance overall system efficiency. However, existing neuromorphic devices are typically limited to operation at room temperature, restricting their applications in extreme environments. Here, the use of wide‐bandgap ε‐Ga2O3 photo‐synapses as image pre‐processors is demonstrated, even at temperatures as high as 650 K. This is possible because of the high‐quality ε‐Ga2O3 epitaxial films, which exhibit angstrom‐level surface roughness, as evidenced by the highly uniform 152 photodetector devices. These devices show enhanced photo‐synaptic behavior at elevated temperatures, enabling high‐temperature image compression capability. The 4 × 4‐pixel images are compresed into 4 × 1 vectors, achieving an image recognition accuracy of 100% at 650 K. This work demonstrates the potential of ε‐Ga2O3 artificial synapses for extremely high‐temperature computing.
Considering Present‐Day Communities in Archaeological Remote Sensing of Burial Spaces: Introduction to Special Issue
Authors: Sturm Jennie O. , Herrmann Jason T. 
Published: December 2024

ABSTRACTIn this editorial, we introduce the Special Issue, ‘Considering Present‐Day Communities in Archaeological Remote Sensing of Burial Spaces’. What does it mean to consider present‐day communities when we do geophysical surveys in burial spaces? This is the conversation we hoped to spark through this Special Issue, and the authors who contributed manuscripts to this Special Issue rose to this challenge. Within this Special Issue, readers will find thoughtful and thought‐provoking insights into many aspects of this work. While many of the authors present technical information on methods, approaches, and analyses of data from specific cemeteries, it is their engagement with these higher‐level questions that AP readers who engage in this type of work are likely to find most stimulating.