bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward New Classification Criteria for Juvenile Idiopathic Arthritis: First Steps, Pediatric Rheumatology International Trials Organization International Consensus
Authors: Martini Alberto , Ravelli Angelo , Avcin Tadej , Beresford Michael W. , Burgos-Vargas Ruben , Cuttica Ruben , Ilowite Norman T. , Khubchandani Raju , Laxer Ronald M. , Lovell Daniel J. , Petty Ross E. , Wallace Carol A. , Wulffraat Nico M. , Pistorio Angela , Ruperto Nicolino ,   for the Pediatric Rheumatology International Trials Organization (PRINTO)
Published: October 2018

Objective.To revise the current juvenile idiopathic arthritis (JIA) International League of Associations for Rheumatology (ILAR) classification criteria with an evidence-based approach, using clinical and routine laboratory measures available worldwide, to identify homogeneous clinical groups and to distinguish those forms of chronic arthritis typically seen only in children from the childhood counterpart of adult diseases.Methods.The overall project consists of 4 steps. This work represents Step 1, a Delphi Web-based consensus and Step 2, an international nominal group technique (NGT) consensus conference for the new provisional Pediatric Rheumatology International Trials Organization JIA classification criteria. A future large data collection of at least 1000 new-onset JIA patients (Step 3) followed by analysis and NGT consensus (Step 4) will provide data for the evidence-based validation of the JIA classification criteria.Results.In Step 1, three Delphi rounds of interactions were implemented to revise the 7 ILAR JIA categories. In Step 2, forty-seven questions with electronic voting were implemented to derive the new proposed criteria. Four disorders were proposed: (a) systemic JIA; (b) rheumatoid factor–positive JIA; (c) enthesitis/spondylitis-related JIA; and (d) early-onset antinuclear antibody–positive JIA. The other forms were gathered under the term “others.” These will be analyzed during the prospective data collection using a list of descriptors to see whether the clustering of some of them could identify homogeneous entities.Conclusion.An international consensus was reached to identify different proposed homogeneous chronic disorders that fall under the historical termJIA. These preliminary criteria will be formally validated with a dedicated project.
Longterm Data on Sirolimus Treatment in Patients with Lupus Nephritis
Authors: Yap Desmond Y.H. , Tang Colin , Chan Gary C.W. , Kwan Lorraine P.Y. , Ma Maggie K.M. , Mok Maggie M.Y. , Chan Tak Mao 
Published: October 2018

Objective.To expand the limited longterm data on sirolimus treatment in patients with lupus nephritis (LN). Our pilot short-term data suggested efficacy of sirolimus treatment in these patients.Methods.We retrospectively reviewed 16 class III/IV/V patients with LN who have received prednisolone (PSL) and sirolimus either as initial or maintenance treatment.Results.Sixteen patients received sirolimus treatment (9 because of intolerance to standard immunosuppressants and 7 because of a history of malignancy) for 45.3 ± 36.5 months. In 5 patients, sirolimus and PSL were given as induction for active nephritis, and they showed improvements in proteinuria (2.8 ± 1.9 g/day at baseline, 0.1 ± 0.1 g/day after 36 mos, p = 0.011), anti-dsDNA (107.7 ± 91.9 IU/ml and 37.0 ± 55.4 IU/ml, respectively, p = 0.178), and C3 (54.8 ± 26.1 mg/dl and 86.3 ± 18.6 mg/dl, respectively, p = 0.081). Eleven patients received sirolimus and low-dose PSL as longterm maintenance, and they showed continued improvement in C3 (90.4 ± 18.1 mg/dl and 117.7 ± 25.1 mg/dl at commencement and after 36 mos, respectively, p = 0.025), stable renal function (estimated glomerular filtration rate 58.6 ± 25.8 ml/min and 63.0 ± 29.6 ml/min, respectively, p = 0.239), and proteinuria (0.8 ± 0.7 g/day and 0.7 ± 0.7 g/day respectively, p = 0.252). Renal flare occurred in 1 patient, and another patient who had stage 4 chronic kidney disease when sirolimus was started developed endstage renal failure after 27 months. Sirolimus was discontinued in 5 patients, in 4 cases related to drug side effects. Deterioration of dyslipidemia occurred in 4 patients, but was adequately controlled with statin therapy.Conclusion.The preliminary evidence suggests that sirolimus may serve as an alternative treatment for patients with LN who do not tolerate standard treatment or who had a history of malignancy, and it has an acceptable longterm safety profile.
Information Processing and Data Management Technology in Wireless Sensor Networks
Authors: Liu Yong , Liang Baohua , Jiang Jiabao 
Published: October 2018

The wireless sensor network is essentially a data-centric network that processes the continuous stream of data, which is collected by different sensors. Therefore, the existing data management technologies regard the wireless sensor network, which is named WSN as a distributed database, and it is composed of continuous data streams from the physical world. Wireless sensor networks are emerging next-generation sensor networks, but their transmission of information is highly dependent. The wireless sensor network processes the continuous stream of data collected by the sensor. Based on the features of wireless sensor networks, this paper presents a topology-dependent model of cluster evolution with fault tolerance. Through the limited data management, resources have reasonably configured, while also saving energy. The model is based on the energy-aware routing protocol in its network layer protocols. The key point is the energy routing principle. According to its own local view, the cluster head node builds the inter-cluster topology to achieve fault-tolerant and energy-saving goals. Simulation results show that the model has good fault tolerance and energy efficiency.
A Social Robotic Obesity Management and Awareness System for Children in Saudi Arabia
Authors: Alotaibi Mohammed 
Published: October 2018

The prevalence of obesity and overweight among children has increased significantly during last two decades in Saudi Arabia with overwhelming consequences to public health. Most recommended approaches to reduce obesity have paying attention on healthier diet and physical Activity (PA). The recent research shows that the use of social robots can contribute in fulfilling all the needs to encourage children to improve their skills in self-management. As children need to be surprised and feel a sense of enjoyment when involving in any activity where they can spend time, effort and be dedicated to. Hereby, this paper presents an innovation social Robotic system to offer a set of activities to help obese children in improving their capabilities to manage their selves properly and increase their obesity knowledge. The proposed system presented in this paper will be tested and evaluated extensively in a random controlled trial in Saudi Arabia.
Implementation of a Clinical Pathway to Reduce Rates of Postextubation Stridor
Authors: Lange Megan , Badjatia Neeraj , Chang Wan-Tsu 
Published: October 2018

Background
Unsuccessful extubation is associated with increased intensive care unit and hospital length of stays, hospital costs, morbidity, and mortality. The most common cause of reintubation is laryngeal edema, often evidenced by postextubation stridor.

Objective
To reduce the rates of postextubation stridor and reintubation in the neurocritical care unit at a large urban academic medical center.

Methods
A clinical pathway was created to aid in detecting patients expected to experience postextubation stridor and to guide prophylactic treatment. During the 12-week implementation phase, the pathway was completed on all intubated patients daily.

Results
The 12-week trial included a total of 606 days of mechanical ventilation. Checklists were completed for 531 days, a compliance rate of 88% for use of the clinical pathway. Of the 56 patients who were extubated during the trial, 54 had a checklist completed, for 96% compliance on the day of extubation. Outcomes after all nonpalliative extubations (n = 43) during the 12 weeks before and after implementation of the pathway (n = 56 periods) were evaluated by using χ2 tests. Implementation of the pathway was associated with a significant reduction in rates of postextubation stridor (χ2 = 6.2; P = .01), reintubation (χ2 = 5.5; P = .02), and reintubation due to postextubation stridor (χ2 = 8.3; P = .004).

Conclusion
The clinical pathway implemented in the neurocritical care unit was safe and effective in reducing rates of reintubation and reintubation due to postextubation stridor.
Lysyl–Transfer RNA Synthetase Induces the Maturation of Dendritic Cells through MAPK and NF-κB Pathways, Strongly Contributing to Enhanced Th1 Cell Responses
Authors: Lim Hui Xuan , Jung Hak-Jun , Lee Arim , Park Si Hoon , Han Byung Woo , Cho Daeho , Kim Tae Sung 
Published: October 2018

Abstract
In addition to essential roles in protein synthesis, lysyl–tRNA synthetase (KRS) is secreted to trigger a proinflammatory function that induces macrophage activation and TNF-α secretion. KRS has been associated with autoimmune diseases such as polymyositis and dermatomyositis. In this study, we investigated the immunomodulatory effects of KRS on bone marrow–derived dendritic cells (DCs) of C57BL/6 mice and subsequent polarization of Th cells and analyzed the underlying mechanisms. KRS-treated DCs increased the expression of cell surface molecules and proinflammatory cytokines associated with DC maturation and activation. Especially, KRS treatment significantly increased production of IL-12, a Th1-polarizing cytokine, in DCs. KRS triggered the nuclear translocation of the NF-κB p65 subunit along with the degradation of IκB proteins and the phosphorylation of MAPKs in DCs. Additionally, JNK, p38, and ERK inhibitors markedly recovered the degradation of IκB proteins, suggesting the involvement of MAPKs as the upstream regulators of NF-κB in the KRS-induced DC maturation and activation. Importantly, KRS-treated DCs strongly increased the differentiation of Th1 cells when cocultured with CD4+ T cells. The addition of anti–IL-12–neutralizing Ab abolished the secretion of IFN-γ in the coculture, indicating that KRS induces Th1 cell response via DC-derived IL-12. Moreover, KRS enhanced the OVA-specific Th1 cell polarization in vivo following the adoptive transfer of OVA-pulsed DCs. Taken together, these results indicated that KRS effectively induced the maturation and activation of DCs through MAPKs/NF-κB–signaling pathways and favored DC-mediated Th1 cell response.
Cutting Edge: Local Proliferation of Uterine Tissue-Resident NK Cells during Decidualization in Mice
Authors: Sojka Dorothy K. , Yang Liping , Plougastel-Douglas Beatrice , Higuchi Darryl A. , Croy B. Anne , Yokoyama Wayne M. 
Published: October 2018

Abstract
NK cells accumulate in adult murine and human uteri during decidualization induced physiologically, pathologically, or experimentally. Adoptive transfer studies indicate that uterine NK (uNK) cells arise from circulating progenitors. However, virgin uteri contain few circulating NK1.1+CD49a− conventional NK cells, whereas NK1.1+CD49a+ tissue-resident NK (trNK) cells are abundant. In this study, we employed a novel, immune-competent NK cell–specific reporter mouse to track accumulation of uNK cells during unmanipulated pregnancies. We identified conventional NK and trNK cells accumulating in both decidua basalis and myometrium. Only trNK cells showed evidence of proliferation. In parabiosis studies using experimentally induced deciduomata, the accumulated uNK cells were proliferating trNK cells; migrating NK cells made no contribution. Together, these data suggest proliferating trNK cells are the source of uNK cells during endometrial decidualization.
Perceived organisational support and well-being: The role of psychological capital as a mediator
Authors: Roemer Anja , Harris Chantel 
Published: October 2018

Orientation: Today’s competitive work environment requires organisations and employees to successfully cope with challenges to maintain healthy levels of well-being. It is, therefore, imperative to investigate which organisational and psychological factors contribute to well-being in employees.Research purpose: This study served to analyse whether psychological capital (PsyCap) mediates the relationship between perceived organisational support (POS) and well-being.Motivation for the study: In light of the positive psychology movement, this study aimed to investigate how positive constructs actively contribute to employee well-being. Knowledge of organisational and psychological factors that enhance well-being in employees will be of great benefit to organisations that aim to create positivity in the workplace in order to avoid the negative consequences of work-related stress and a toxic work environment.Research approach/design and method: A cross-sectional, non-experimental design, applying convenience and snowball sampling, was used to recruit 159 South African employees who completed an online survey that assessed the constructs under investigation.Main findings: It was found that POS, PsyCap and well-being are positively correlated to one another. Moreover, hierarchical regression analyses revealed that PsyCap fully mediates the relationship between POS and well-being.Practical/managerial implications: These findings imply that organisations should be committed to target their employees’ PsyCap to enhance well-being in their workforce.Contribution/value-add: The findings show that it is not sufficient just to provide organisational support to enhance well-being. Organisations also need to acknowledge the important role of their employees’ PsyCap to ensure that they are well equipped to deal with challenges in the workplace while maintaining healthy levels of well-being.
Combined impacts of ENSO and MJO on the 2015 growing season drought on the Canadian Prairies
Authors: Li Zhenhua , Li Yanping , Bonsal Barrie , Manson Alan H. , Scaff Lucia 
Published: October 2018

Abstract. Warm-season precipitation on the Canadian Prairies plays a crucial role in
agricultural production. This research investigates how the early summer 2015
drought across the Canadian Prairies is related to the tropical Pacific
forcing. The significant deficit of precipitation in May and June 2015
coincided with a warm phase of the El Niño–Southern Oscillation (ENSO) and a
negative phase of Madden–Julian Oscillation (MJO)-4 index, which favour a
positive geopotential height (GPH) anomaly in western Canada. Our further
investigation during the instrumental record (1979–2016) shows that
warm-season precipitation in the Canadian Prairies and the corresponding
atmospheric circulation anomalies over western Canada teleconnected with the
lower boundary conditions in the tropical western Pacific. Our results
indicate that MJO can play a crucial role in determining the summer
precipitation anomaly in the western Canadian Prairies when the equatorial
central Pacific is warmer than normal (NINO4 > 0) and MJO is more
active. This teleconnection is due to the propagation of a stationary Rossby
wave that is generated in the MJO-4 index region. When the tropical
convection around MJO-4 index region (western tropical Pacific, centred over
140∘ E) is more active than normal (NINO4 > 0), Rossby
wave trains originate from the western Pacific with wavenumbers determined by
the background mean wind and meridional absolute vorticity gradient. Under
warm NINO4 conditions waves are generated with smaller wavenumbers compared
to cold NINO4 conditions. These waves under warm NINO4 can propagate into the
mid-latitudes over North America, causing a persistent anomalous ridge in the
upper level over western Canada, which favours dry conditions over the
region.
Representation of basal melting at the grounding line in ice flow models
Authors: Seroussi Hélène , Morlighem Mathieu 
Published: October 2018

Abstract. While a lot of attention has been given to the numerical implementation of
grounding lines and basal friction in the grounding zone, little has been
done about the impact of the numerical treatment of ocean-induced basal
melting in this region. Several strategies are currently being employed in
the ice sheet modeling community, and the resulting grounding line dynamics
may differ strongly, which ultimately adds significant uncertainty to the
projected contribution of marine ice sheets to sea level rise. We investigate
here several implementations of basal melt parameterization on partially
floating elements in a finite-element framework, based on the Marine Ice
Sheet–Ocean Model Intercomparison Project (MISOMIP) setup: (1) melt applied
only to entirely floating elements, (2) melt applied over all elements that
are crossed by the grounding line, and (3) melt integrated partially over the
floating portion of a finite element using two different sub-element
integration methods. All methods converge towards the same state when the
mesh resolution is fine enough. However, (2) and (3) will systematically
overestimate the rate of grounding line retreat in coarser resolutions, while
(1) converges faster to the solution in most cases. The differences between
sub-element parameterizations are exacerbated for experiments with high
melting rates in the vicinity of the grounding line and for a Weertman
sliding law. As most real-world simulations use horizontal mesh resolutions
of several hundreds of meters at best, and high melt rates are generally
present close to the grounding lines, we recommend not using (3) to avoid
overestimating the rate of grounding line retreat and to carefully assess the
impact of mesh resolution and sub-element melt parameterizations on all
simulation results.
Assessing the Efficacy of Maropitant Versus Ondansetron in the Treatment of Dogs with Parvoviral Enteritis
Authors: Sullivan Lauren A. , Lenberg Jamie P. , Boscan Pedro , Hackett Timothy B. , Twedt David C. 
Published: October 2018

ABSTRACT
Antiemetics are commonly prescribed during the treatment of canine parvoviral enteritis. This blinded, randomized prospective study compared the quality of clinical recovery and duration of hospitalization in canine parvoviral dogs receiving either maropitant (1 mg/kg [0.45 mg/lb] IV q 24 hr, n = 11) or ondansetron (0.5 mg/kg [0.23 mg/lb] IV q 8 hr, n = 11). All dogs were treated with IV fluids, cefoxitin, and enteral nutrition. Frequency of vomiting and pain scoring were recorded twice daily. Rescue analgesics and antiemetics were administered as dictated by specific pain and vomiting criteria. Clinical severity scoring, body weight, and caloric intake were monitored daily. When comparing dogs receiving maropitant versus ondansetron, respectively, there were no differences in duration of hospitalization (3.36 ± 0.56 versus 2.73 ± 0.38 days, P = .36), requirement of rescue antiemetic (3/11 versus 5/11 dogs, P = .66), duration of vomiting (5 versus 4 days, P = .65), or days to voluntary food intake (2 versus 1.5 days, P = 1.0). Results of this study suggest that maropitant and ondansetron are equally effective in controlling clinical signs associated with parvoviral enteritis.
Online Behavior Recognition: Can We Consider It Biometric Data under GDPR?
Authors: Krausová Alžběta 
Published: October 2018

Our everyday use of electronic devices and search for various contents online provides valuable insights into our functioning and preferences. Companies usually extract and analyze this data in order to predict our future behavior and to tailor their marketing accordingly. In terms of the General Data Protection Regulation such practice is called profiling and is subject to specific rules. However, the behavior analysis can be used also for unique identification or verification of identity of a person. Therefore, this paper claims that under certain conditions data about online behavior of an individual fall into the category of biometric data within the meaning defined by the GDPR. Moreover, this paper claims that profiling of a person can not only be done upon existing biometric data as biometric profiling but it can also lead to creation of new biometric data by constituting a new biometric template. This claim is based both on legal interpretation of the concepts of biometric data, unique identification, and profiling as well as analysis of existing technologies. This article also explains under which conditions online behavior can be considered biometric data under the GDPR, at which point profiling results in creation of new biometric data and what are the consequences for a controller and data subjects.
Comunidades, racionalidad y mercados: una crítica institucional a la defensa emancipadora de la economía colaborativa
Authors: Laín Escandell Bru 
Published: October 2018

Este artículo discute la llamada economía colaborativa para señalar, en primer y segundo lugar, algunas dificultades que aparecen (o pueden aparecer) a la hora de comprenderla tanto en términos analíticos como conceptuales. En tercer lugar, expone dos de las interpretaciones más extendidas actualmente para, en cuarto lugar, centrarse en aquella que atribuye a la economía colaborativa un carácter emancipador. En particular, se discuten tres importantes limitaciones a las que usualmente debe hacer frente dicha perspectiva: el excesivo protagonismo que otorga a las comunidades colaborativas y al principio de paraigualdad; su modo de entender la racionalidad humana; y su visión a-institucional y meramente psicológica de la naturaleza y el funcionamiento de los mercados. El artículo concluye sugiriendo que, para lograr que la economía colaborativa despliegue su potencial emancipador, se requieren instituciones sociales y políticas que pongan a funcionar dicha colaboración en beneficio de todas y todos.This paper discusses the so-called collaborative economy, first and second, by pointing out some difficulties that appear (or can appear) in its understanding, both in conceptual and analytical terms. In the third section, two of its most currently widespread interpretations are analysed, while the fourth section focusses in the one that imputes to it an emancipatory character. In particular, three of this interpretation’s most usual boundaries are analysed: the excessive prominence that it confers to collaborative communities and to the principle of egalitarianism; its understanding of the human rationality; and its a-institutional and its mere psychologic approach to the nature and the functioning of markets. The paper concludes by suggesting that, in order to collaborative economy deploy its emancipatory potential, social and political institutions that turns collaboration in benefiting everyone are required.