bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of High-Resolution Sounding Data to Evaluate and Optimize Nonlocal PBL Schemes for Simulating the Slightly Stable Upper Convective Boundary Layer
Authors: Hu Xiao-Ming , Xue Ming , Li Xiaolan 
Published: August 2019

AbstractSince the 1950s, a countergradient flux term has been added to some K-profile-based first-order PBL schemes, allowing them to simulate the slightly statically stable upper part of the convective boundary layer (CBL) observed in a limited number of aircraft soundings. There is, however, substantial uncertainty in inferring detailed CBL structure, particularly the level of neutral stability (zn), from such a limited number of soundings. In this study, composite profiles of potential temperature are derived from multiyear early afternoon radiosonde data over Beijing, China. The CBLs become slightly stable above zn ~ 0.31–0.33zi, where zi is the CBL depth. These composite profiles are used to evaluate two K-profile PBL schemes, the Yonsei University (YSU) and Shin–Hong (SH) schemes, and to optimize the latter through parameter calibration. In one-dimensional simulations using the WRF Model, YSU simulates a stable CBL above zn ~ 0.24zi, while default SH simulates a thick superadiabatic lower CBL with zn ~ 0.45zi. Experiments with the analytic solution of a K-profile PBL model show that adjusting the countergradient flux profile leads to significant changes in the thermal structure of CBL, informing the calibration of SH. The SH scheme replaces the countergradient heat flux term in its predecessor YSU scheme with a three-layer nonlocal heating profile, with fnl specifying the peak value and specifying the height of this peak value. Increasing fnl to 1.1 lowers zn, but to too low a value, while simultaneously increasing to 0.4 leads to a more appropriate zn ~ 0.36zi. The calibrated SH scheme performs better than YSU and default SH for real CBLs.
Observations of Near-Surface Vertical Wind Profiles and Vertical Momentum Fluxes from VORTEX-SE 2017: Comparisons to Monin–Obukhov Similarity Theory
Authors: Markowski Paul M. , Lis Nathan T. , Turner David D. , Lee Temple R. , Buban Michael S. 
Published: August 2019

AbstractObservations of near-surface vertical wind profiles and vertical momentum fluxes obtained from a Doppler lidar and instrumented towers deployed during VORTEX-SE in the spring of 2017 are analyzed. In particular, departures from the predictions of Monin–Obukhov similarity theory (MOST) are documented on thunderstorm days, both in the warm air masses ahead of storms and within the cool outflow of storms, where MOST assumptions (e.g., horizontal homogeneity and a steady state) are least credible. In these regions, it is found that the nondimensional vertical wind shear near the surface commonly exceeds predictions by MOST. The departures from MOST have implications for the specification of the lower boundary condition in numerical simulations of convective storms. Documenting departures from MOST is a necessary first-step toward improving the lower boundary condition and parameterization of near-surface turbulence (“wall models”) in storm simulations.
Effects of a robot intervention on visuospatial hemineglect in postacute stroke patients: a randomized controlled trial
Authors: Karner Susanne , Stenner Hanna , Spate Melanie , Behrens Johann , Krakow Karsten 
Published: August 2019

Objective: To evaluate the effects of an intervention using the robot device PARO on visuospatial hemineglect and activities of daily living, and its acceptance during stroke rehabilitation. PARO is an interactive robotic toy with the appearance of a baby seal, which can move, produce sounds, and react to speech and touch. Design: A randomized controlled trial. Setting: Hospital for neurorehabilitation. Subjects: Patients above 60 years old who have suffered their first stroke within the previous three months with left hemineglect ( n = 39). Interventions: The PARO group ( n = 21) was exposed to PARO over a period of two weeks, three times per week. The participants of the control group ( n = 18) were read to aloud. Outcome measure: Visuospatial hemineglect was measured by a cancellation test and a Line Bisection Test, and independence in the activities of daily living was assessed by Scores of Independence Index for Neurological and Geriatric Rehabilitation (SINGER) test. The acceptance of PARO was also evaluated. Data were collected blinded at three times: baseline (T0), after two weeks of interventions (T1), and after additional two weeks as follow-up (T2). Results: Improvement of hemineglect at T1 and T2 was significantly higher in the PARO group (T1: mean (SD) = 6.23 (3.81); T2: mean (SD) = 7.85 (3.68)) compared to the control group (T1: mean (SD) = 2.66 (4.19); T2: mean (SD) = 3.33 (4.16)) (T1: P < 0.05; T2: P < 0.05). Conclusion: The study showed that the use of the PARO is well accepted and can help to improve neglect symptoms in patients with subacute stroke.
Predictors of the Clinical Course of Tourette Syndrome: A Longitudinal Study
Authors: Groth Camilla , Skov Liselotte , Lange Theis , Debes Nanette M. 
Published: August 2019

Objective: Tourette syndrome (TS) is a chronic childhood neurodevelopmental disorder characterized by motor and vocal tics and frequent comorbidities. The clinical presentation of Tourette syndrome is heterogeneous and the prognosis for each individual child is difficult to define. This large prospective longitudinal study explores predictors in childhood of the clinical course of tics and comorbidities in early adulthood. Methods: The cohort was recruited at the Danish National Tourette Clinic. Data were collected at baseline (N = 314; ages, 5-19 years) and follow-up 6 years later (n = 227; ages, 11-26 years) to examine changes in the expression of tics and comorbidities. Childhood clinical factors, represented by 4 binary clinical outcomes, were selected as possible predictors of the clinical course of tics and comorbidities in early adulthood; these were tic severity and diagnoses of obsessive compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD), and emotional disorders. Results: The strongest predictors of high tic scores, OCD, or ADHD diagnoses in early adulthood were the corresponding tic (odds ratio [OR]: 1.09), OCD (OR: 1.08), and ADHD (OR: 1.13) severity scores (per scale point) in childhood. Being female (OR: 3.94) and childhood ADHD severity (OR: 1.11) predicted future emotional disorders. Special education, genetic factors, and psychosocial factors were also predictive for the clinical course of Tourette syndrome. Conclusion: We identified strong clinical predictors of Tourette syndrome–associated outcomes in early adulthood that are directly applicable to clinical Tourette syndrome populations and may help to guide new patients, plan early interventions, and implement preventive measures.
Risk factors for bone loss in juvenile-onset systemic lupus erythematosus: a prospective study
Authors: de Sousa L F A , Paupitz J A , Aikawa N E , Takayama L , Caparbo V F , Pereira R M R 
Published: August 2019

Objective Juvenile-onset systemic lupus erythematosus (JoSLE) is associated with low bone mass for age and fractures; nevertheless, risk factors for bone impairment are poorly understood. The aim of this study was to evaluate risk factors for bone mass loss in JoSLE patients. Methods Forty-nine female JoSLE patients were evaluated at baseline and after a 3.5-year follow-up regarding clinical, laboratory (including bone turnover markers), areal bone mineral density (aBMD) and bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT). Based on the difference between final and baseline aBMD value, the patients were divided into three groups: aBMD gain (BG), aBMD loss (BL) and aBMD no change (NC). Results The mean patient age was 18.7 ± 3.3 years. Sixty-one percent of patients presented with aBMD gain, 18.4% aBMD loss, and 20.4% remained stable during this follow-up period. Comparing the BL with the BG group, there was a higher frequency of alcohol consumption ( p = 0.009), a higher frequency of inadequate calcium intake ( p = 0.047) and lower levels of baseline procollagen type 1 amino-terminal propeptide (P1NP) ( p = 0.036) in the BL group. Moreover, worsening of HR-pQCT parameters trabecular volumetric density ( p = 0.003) and cortical thickness ( p = 0.009) was observed in the BL group. In addition, a higher frequency of renal activity was observed comparing the BL + NC with the BG group ( p = 0.036). Conclusions This is the first longitudinal study that has analyzed the risk factors of bone loss in JoSLE patients. The authors emphasize the importance of evaluating lifestyle habits and renal disease activity in these young women. Furthermore, this study suggests that trabecular and cortical compartments deteriorated, and low levels of P1NP may be a predictor of bone impairment in JoSLE.
Temporally separated feline calicivirus isolates do not cluster phylogenetically and are similarly neutralised by high-titre vaccine strain FCV-F9 antisera in vitro
Authors: Smith Shirley L , Afonso Maria M , Pinchbeck Gina L , Gaskell Rosalind M , Dawson Susan , Radford Alan D 
Published: August 2019

Objectives Feline calicivirus (FCV) is a highly variable and globally important feline pathogen for which vaccination has been the mainstay of control. Here, we test whether the continued use of FCV-F9, one of the most frequently used vaccine strains globally, is driving the emergence of vaccine-resistant viruses in the field. Methods This study made use of two representative panels of field isolates previously collected from cats visiting randomly selected veterinary practices across the UK as part of separate cross-sectional studies from 2001 and 2013/2014. Phylogenetic analysis and in vitro virus neutralisation tests were used to compare the genetic and antigenic relationships between these populations and FCV-F9. Results Phylogenetic analysis showed a typically radial distribution dominated by 52 distinct strains, with strains from both 2001 and 2013/2014 intermingled. The sequence for FCV-F9 appeared to be integral to this phylogeny and there were no significant differences in the genetic distances within each studied population (intra-population distances), or between them (inter-population distances), or between each population and FCV-F9. A 1 in 8 dilution neutralised 97% and 100% of the 2001 and 2013/14 isolates, respectively, and a 1 in 16 dilution neutralised 87% and 75% of isolates, respectively. There was no significant difference either in variance between the FCV-F9 neutralising titres for the two populations, or in the distribution of neutralisation titres across the two populations. Conclusions and relevance Although FCV is a highly variable virus, we found no evidence for a progressive divergence of field virus from vaccine strain FCV-F9, either phylogenetically or antigenically, with FCV-F9 antisera remaining broadly and equally cross-reactive to two geographically representative and temporally separated FCV populations. We suggest this may be because the immunodominant region of the FCV capsid responsible for neutralisation may have structural constraints preventing its longer term progressive antigenic evolution.
Potential Impact on Lipoprotein Subfractions in Type 2 Diabetes
Authors: Kamijo Yuka , Ishii Hideto , Yamamoto Tomohiko , Kobayashi Kunihisa , Asano Hiroyuki , Miake Shunji , Kanda Eiichiro , Urata Hidenori , Yoshida Masayuki 
Published: August 2019

Introduction: Recently, the sodium-glucose cotransporter2 (SGLT2) inhibitor empagliflozin has been shown to lower cardiovascular risk among diabetic patients. It is intriguing that some SGLT2 inhibitors have been found to increase low-density lipoprotein (LDL) cholesterol levels, while the relevance to high-density lipoprotein (HDL) cholesterol is unknown. Although the inhibitory effect of SGLT2 inhibitors on glucose reabsorption may accelerate compensatory lipid metabolism and subsequently reduce body weight and affect the lipid profile, much remains unclear about this mechanism. Therefore, we conducted this study to investigate in detail how canagliflozin affects lipoprotein fractions including LDL and HDL subclasses. Materials and Methods: This study is a multicenter prospective study. The participants were patients with 22 type 2 diabetes (60.7 ± 11.6 years, 59.1% of men) who had HbA1c ⩾ 7.0% and consented to participate in the study. They were administered 100 mg canagliflozin orally once per day. Biochemistry test and cholesterol levels of 20 lipoprotein fractions (G1-G20) using high performance liquid chromatography methods were examined before and after 12 weeks of treatment period. Results: Significant decreases were observed in the participants’ body weight (69.7 to 67.9 kg, P < .001), systolic blood pressure (129.3 to 119.5 mm Hg, P < .01), and HbA1c (8.5% to 7.4%, P < .001). Cholesterol levels in the 20 lipoprotein fractions increased for very large HDL (G14, G15) and large HDL (G16) ( P < .05). Conclusions: Reduction in body weight, improvement of blood glucose levels, and increases in very large HDL and large HDL subclasses were observed after canagliflozin treatment. These beneficial changes might contribute to subsequent suppression of cardiovascular outcomes.
Outcomes of scapulothoracic fusion in facioscapulohumeral muscular dystrophy: A systematic review
Authors: Kord Dorsa , Liu Eva , Horner Nolan S , Athwal George S , Khan Moin , Alolabi Bashar 
Published: August 2019

Background Facioscapulohumeral muscular dystrophy (FSHD) is a rare condition associated with selective weakness of the muscles of the upper arm, face, and shoulder girdle, negatively affecting daily activities. Scapulothoracic arthrodesis may restore shoulder function and improve quality of life. The purpose of this review is to evaluate the outcomes and complications of scapulothoracic arthrodesis in FSHD patients. Methods Medline, Pubmed, and Embase were systematically searched. Studies were included if they described scapulothoracic arthrodesis in FSHD with follow-up, and outcomes were adequately reported. Thirteen eligible articles reported the outcomes of 199 arthrodesis in 130 patients. Results The mean gain of shoulder forward elevation and abduction were 45° (p < 0.05) and 40° (p < 0.05), respectively. There was an overall cosmetic satisfaction and improved performance of daily activities. There is limited and heterogeneous data on changes in pulmonary function, but such changes are clinically insignificant. The rate of complications was 41% of which 10% were serious, requiring an intervention or re-admission. The most common complications were hardware failure (8%), non-union (6%), and pneumothorax (5%). Discussion Scapulothoracic arthrodesis improved cosmesis, performance of daily activities and shoulder motion with no clinically significant loss of pulmonary function. The complication rate is high, and some are potentially serious.
Mid-term results of a stemless ceramic on polyethylene shoulder prosthesis – A prospective multicentre study
Authors: Jordan RW , Kelly CP , Pap G , Joudet T , Nyffeler RW , Reuther F , Irlenbusch U 
Published: August 2019

Introduction Early reports of stemless shoulder arthroplasty have shown promising clinical and radiological outcomes. The purpose of this study was to report on the mid-term results of an implant that utilises a ceramic humeral head. Methods A prospective, consecutive, multicentre study of stemless shoulder prosthesis with a minimum of four years of follow-up was conducted between August 2009 and May 2012. The adjusted Constant–Murley Score (CMS), revision rate and presence of radiolucent lines were recorded at intervals. Results A total of 207 patients were eligible for study inclusion; 62.8% were female and mean age was 64.8 years (range 30–86). Mean follow-up was 70.7 months (range 48–100), 73% underwent TSA and 27% hemiarthroplasty. The mean CMS improvement was 42.6 (p < 0.0001) at 48 months. Radiolucencies were present in 2.7% of humeral zones and 14% of glenoid zones at 48-month follow-up. The revision rate was 6.3% with rotator cuff failure (2.9%) the most common indication. Conclusions Mid-term results demonstrate that the studied stemless implant with a ceramic humeral head had clinical and radiological outcomes that are comparable to other reported studies.
Tarsal Tunnel Syndrome Secondary to Accessory Musculature: A Case Report
Authors: Neary Kaitlin C. , Chang Eric , Kreulen Christopher , Giza Eric 
Published: August 2019

Tarsal tunnel syndrome (TTS) is a relatively uncommon compression neuropathy caused by impingement of the tibial nerve or one of the terminal branches. The presence of accessory musculature at the posteromedial aspect of the ankle has been identified as a rare cause of this condition. Despite the rarity of this condition, it must be considered in patients with refractory symptoms consistent with tibial nerve dysfunction. The accurate diagnosis of this condition relies heavily on a detailed history and physical examination, adequate imaging read by both surgeon and trained musculoskeletal radiologist, as well as a high level of suspicion for such pathology. In this case report, we describe a 46-year-old male with history, examination, and imaging all consistent with TTS secondary to accessory musculature. Following excision of an accessory soleus and flexor digitorum accessorius longus, as well as simultaneous tarsal tunnel release, the patient experienced full resolution of his symptoms. This highlights the importance of considering accessory musculature as a potential cause of TTS in patients presenting with tibial compression neuropathy. Levels of Evidence: Level V: Case Report
Combined melatonin and poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and β-catenin pathway in AKI-to-CKD continuum
Authors: Chen Dan-Qian , Cao Gang , Zhao Hui , Chen Lin , Yang Tian , Wang Ming , Vaziri Nosratola D. , Guo Yan , Zhao Ying-Yong 
Published: August 2019

Background: Acute kidney injury (AKI) is one of the major risk factors for progression to chronic kidney disease (CKD) and renal fibrosis. However, effective therapies remain poorly understood. Here, we examined the renoprotective effects of melatonin and poricoic acid A (PAA) isolated from the surface layer of Poria cocos, and investigated the effects of combined therapy on the interaction of TGF-β/Smad and Wnt/β-catenin in a rat model of renal ischemia-reperfusion injury (IRI) and hypoxia/reoxygenation (H/R) or TGF-β1-induced HK-2 cells. Methods: Western blot and immunohistochemical staining were used to examine protein expression, while qRT-PCR was used to examine mRNA expression. Coimmunoprecipitation, chromatin immunoprecipitation, RNA interference, and luciferase reporter gene analysis were employed to explore the mechanisms of PAA and melatonin’s renoprotective effects. Results: PAA and combined therapy exhibited renoprotective and antifibrotic effects, but the underlying mechanisms were different during AKI-to-CKD continuum. Melatonin suppressed Smad-dependent and Smad-independent pathways, while PAA selectively inhibited Smad3 phosphorylation through distrupting the interactions of Smad3 with TGFβRI and SARA. Further studies demonstrated that the inhibitory effects of melatonin and PAA were partially depended on Smad3, especially PAA. Melatonin and PAA also inhibited the Wnt/β-catenin pathway and its profibrotic downstream targets, and PAA performed better. We further determined that IRI induced a nuclear Smad3/β-catenin complex, while melatonin and PAA disturbed the interaction of Smad3 and β-catenin, and supplementing with PAA could enhance the inhibitory effects of melatonin on the TGF-β/Smad and Wnt/β-catenin pathways. Conclusions: Combined melatonin and PAA provides a promising therapeutic strategy to treat renal fibrosis during the AKI-to-CKD continuum.
Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial
Authors: Lown E Anne , Banerjee Anu , Vittinghoff Eric , Dvorak Christopher C , Hartogensis Wendy , Melton Alexis , Mangurian Christina , Hu Hiroe , Shear Deborah , Adcock Robyn , Morgan Michael , Golden Carla , Hecht Frederick M 
Published: August 2019

Background We describe the study design and protocol of a pragmatic randomized controlled trial (RCT) Acupressure for Children in Treatment for a Childhood Cancer (ACT-CC). Objective To describe the feasibility and effectiveness of an acupressure intervention to decrease treatment-related symptoms in children in treatment for cancer or recipients of a chemotherapy-based hematopoietic stem cell transplant (HSCT). Design Two-armed RCTs with enrollment of 5 to 30 study days. Setting Two pediatric teaching hospitals. Patients Eighty-five children receiving cancer treatment or a chemotherapy-based HSCT each with 1 parent or caregiver. Intervention Patients are randomized 1:1 to receive either usual care plus daily professional acupressure and caregiver delivered acupressure versus usual care alone for symptom management. Participants receive up to 20 professional treatments. Main Outcome A composite nausea/vomiting measure for the child. Secondary Outcomes Child’s nausea, vomiting, pain, fatigue, depression, anxiety, and positive affect. Parent Outcomes Depression, anxiety, posttraumatic stress symptoms, caregiver self-efficacy, and positive affect. Feasibility of delivering the semistandardized intervention will be described. Linear mixed models will be used to compare outcomes between arms in children and parents, allowing for variability in diagnosis, treatment, and age. Discussion Trial results could help childhood cancer and HSCT treatment centers decide about the regular inclusion of trained acupressure providers to support symptom management.
An Overview and Critique of US Immigration and Asylum Policies in the Trump Era
Authors: Schmidt Paul Wickham 
Published: August 2019

Executive Summary This article provides an overview and critique of US immigration and asylum policies from the perspective of the author’s 46 years as a public servant. The article offers a taxonomy of the US immigration system by positing different categories of membership: full members of the “club” (US citizens), associate members (lawful permanent residents, refugees, and “asylees”), friends (nonimmigrants and holders of temporary status), and persons outside the club (the undocumented). It describes the legal framework that applies to these distinct populations and recent developments in federal law and policy that relate to them. It also identifies a series of cross-cutting issues that affect these populations, including immigrant detention, immigration court backlogs, state and local immigration policies, and constitutional rights that extend to noncitizens. It ends with a series of recommendations for reform of the US asylum system, and a short conclusion.