bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of an Adrenocortical Cancer Humanized Mouse Model to Characterize Anti-PD1 Effects on Tumor Microenvironment
Authors: Lang Julie , Capasso Anna , Jordan Kimberly R , French Jena D , Kar Adwitiya , Bagby Stacey M , Barbee Jacob , Yacob Betelehem W , Head Lia S , Tompkins Kenneth D , Freed Brian M , Somerset Hilary , Clark Toshimasa J , Pitts Todd M , Messersmith Wells A , Eckhardt S Gail , Wierman Margaret E , Leong Stephen , Kiseljak-Vassiliades Katja 
Published: September 2019

Abstract

Context
Although the development of immune checkpoint inhibitors has transformed treatment strategies of several human malignancies, research models to study immunotherapy in adrenocortical carcinoma (ACC) are lacking.

Objective
To explore the effect of anti-PD1 immunotherapy on the alteration of the immune milieu in ACC in a newly generated preclinical model and correlate with the response of the matched patient.

Design, Setting, and Intervention
To characterize the CU-ACC2-M2B patient-derived xenograft in a humanized mouse model, evaluate the effect of a PD-1 inhibitor therapy, and compare it with the CU-ACC2 patient with metastatic disease.

Results
Characterization of the CU-ACC2-humanized cord blood-BALB/c-Rag2nullIl2rγnullSirpaNOD model confirmed ACC origin and match with the original human tumor. Treatment of the mice with pembrolizumab demonstrated significant tumor growth inhibition (60%) compared with controls, which correlated with increased tumor infiltrating lymphocyte activity, with an increase of human CD8+ T cells (P &lt; 0.05), HLA-DR+ T cells (P &lt; 0.05) as well as Granzyme B+ CD8+ T cells (&lt;0.001). In parallel, treatment of the CU-ACC2 patient, who had progressive disease, demonstrated a partial response with 79% to 100% reduction in the size of target lesions, and no new sites of metastasis. Pretreatment analysis of the patient's metastatic liver lesion demonstrated abundant intratumoral CD8+ T cells by immunohistochemistry.

Conclusions
Our study reports the first humanized ACC patient-derived xenograft mouse model, which may be useful to define mechanisms and biomarkers of response and resistance to immune-based therapies, to ultimately provide more personalized care for patients with ACC.
Obesity, Neuroinflammation, and Reproductive Function
Authors: Lainez Nancy M , Coss Djurdjica 
Published: September 2019

AbstractThe increasing occurrence of obesity has become a significant public health concern. Individuals with obesity have higher prevalence of heart disease, stroke, osteoarthritis, diabetes, and reproductive disorders. Reproductive problems include menstrual irregularities, pregnancy complications, and infertility due to anovulation, in women, and lower testosterone and diminished sperm count, in men. In particular, women with obesity have reduced levels of both gonadotropin hormones, and, in obese men, lower testosterone is accompanied by diminished LH. Taken together, these findings indicate central dysregulation of the hypothalamic–pituitary–gonadal axis, specifically at the level of the GnRH neuron function, which is the final brain output for the regulation of reproduction. Obesity is a state of hyperinsulinemia, hyperlipidemia, hyperleptinemia, and chronic inflammation. Herein, we review recent advances in our understanding of how these metabolic and immune changes affect hypothalamic function and regulation of GnRH neurons. In the latter part, we focus on neuroinflammation as a major consequence of obesity and discuss findings that reveal that GnRH neurons are uniquely positioned to respond to inflammatory changes.
A Novel Anti-Cd40 Monoclonal Antibody, Iscalimab, for Control of Graves’ Hyperthyroidism – A Proof-Of-Concept Trial
Authors: Kahaly G J , Stan M N , Frommer L , Gergely P , Colin L , Amer A , Schuhmann I , Espie P , Rush J S , Basson C , He Y L 
Published: September 2019

Abstract

Context
The CD40-CD154 co-stimulatory pathway plays an important role in the pathogenesis of Graves’ disease (GD) by promoting auto-reactive B cell activation.

Objective
Evaluate efficacy and safety of a human, blocking, non-depleting anti-CD40 monoclonal antibody, iscalimab, in hyperthyroid patients with GD

Design
Open label, phase II proof-of-concept study

Setting
Multicenter

Patients
Fifteen with GD

Intervention
Patients received five doses of iscalimab at 10 mg/kg intravenously over 12 weeks.

Main outcome measures
Thyroid-related hormones and autoantibodies, plasma soluble CD40, free CD40 on B cells, soluble CXCL13, pharmacokinetics, and safety were assessed.

Results
The iscalimab intervention resulted in complete CD40 engagement for up to 20 weeks. A clinical response and biochemical euthyroidism was observed in seven of 15 (47%) patients. Free and total T3 and T4 normalized in seven patients who did not receive any rescue medication with anti-thyroid drugs (ATD), and 2/15 (13.3%) showed normal TSH. Six (40%) patients required ATD. Four of seven responders relapsed after treatment completion. Serum concentrations of thyrotropin receptor autoantibodies (TSH-R-Ab) significantly declined in all patients (mean 15.3 IU/L versus 4.0 IU/L, 66% reduction, P<0.001) and TSH-R-Ab levels normalized in four (27%). Thyroperoxidase and thyroglobulin autoantibodies significantly decreased in responders. Iscalimab rapidly reduced serum CXCL13 concentrations (P<0.001). Twelve (80.0%) patients reported at least one adverse event (AE). All treatment-related AE were mild or moderate and resolved by end of the study.

Conclusion
Iscalimab was generally safe and clinically effective in a subgroup of hyperthyroid GD patients. The potential therapeutic benefit of Iscalimab should be further tested.
Opioids and their endocrine effects: A systematic review and meta-analysis
Authors: de Vries Friso , Bruin Mees , Lobatto Daniel J , Dekkers Olaf M , Schoones Jan W , van Furth Wouter R , Pereira Alberto M , Karavitaki Niki , Biermasz Nienke R , Zamanipoor Najafabadi Amir H 
Published: September 2019

Abstract

Context
The increased use of opioids has resulted in an unprecedented opioid epidemic. Chronic opioid use causes hypogonadism, but its frequency, as well as the effects of opioids on other hypothalamo-pituitary-end organ hormone axes, remains unclear.

Objective
The aim of this systematic review and meta-analysis was to assess the effects of opioid use on pituitary function.

Methods
Eight electronic databases were searched for articles published up to May 8, 2018. Fixed- or random-effects meta-analysis was performed to estimate pooled proportions with 95% confidence intervals. This study is reported following the PRISMA- and MOOSE-guidelines.

Data Synthesis
52 studies (22 low risk of bias) were included describing 18,428 subjects, consisting of patients with chronic pain (n=21 studies), or on maintenance treatment for opioid addiction (n=9) and healthy volunteers (n=4). The most frequently used opioid was methadone (n=13 studies), followed by morphine (n=12). Prevalence of hypogonadism was 63% (95% CI: 55-70%, 15 studies, 3,250 patients, 99.5% males). Prevalence of hypocortisolism relying on dynamic and non-dynamic testing was 15% (95% CI: 6-28%, 5 studies, 205 patients, 57.5% males) and including only studies using the insulin tolerance tests 24% (95% CI 16-33%, 2 studies, n=97 patients). In 5 out of 7 studies hyperprolactinemia was present. No clear effects on the somatotropic and hypothalamo-pituitary-thyroid axes were described.

Conclusions
Hypogonadism occurs in more than half of male opioid users, and hypocortisolism in approximately a fifth of all patients. Periodical evaluation of at least the gonadal and adrenal axes is therefore advisable.
Facebook Powered Measurement and Evaluation for Iron Folic Acid Health Intervention in India
Authors: Bernard Drew , McCullough Chris , Francis Sarah , Holton Avery , Diamond-Smith Nadia 
Published: September 2019

As the media landscape changes and billions of people around the world turn to Facebook, Instagram, WhatsApp, and other social media platforms for information and social interactions, the need to develop effective methods of leveraging social media for social behavior change communication (SBCC) becomes increasingly important. Yet, in order for the public health sector to embrace social media for SBCC, we must have methods for measuring the impact of social media-based SBCC. In this letter, we share a new approach for measurement and evaluation of social media-based SBCC campaigns. The approach was developed as part of an iron-folic acid health intervention targeting young women in two states in northern India; Uttar Pradesh and Maydar Pradesh.
Characteristics of people with pressure ulcers using one year's routinely collected data in a defined diverse community
Authors: Jackson Debra , Hutchinson Marie , Neville Stephen , Padula William V. , Usher Kim , Gardner Sarah , Betteridge Ria , Durrant Lisa 
Published: September 2019

Objective: To determine if meaningful patient characteristics pertaining to pressure ulcers (PU) can be derived from routinely collected community health data. Methods: A retrospective cohort analysis of records was carried out. To provide a detailed dataset on PU for the community of interest, demographic, general medical and PU data were extracted from mandatory incident reports and audit of electronic and paper medical records. This study is reported in accordance with the RECORD Guidelines from the Equator Network. Adult patients were enrolled from a district nursing service in the target region (n=1085) during 2015. The target region was based on a geographical region bounded by a single postcode district (target region) consisting of 62,000 people of whom approximately 50,000 were adults, 3000 of whom were aged >75 years. Results: The total number of recorded PUs was n=137 in 103 individuals. Data from mandatory incident reports was obtainable for nearly all variables. Electronic and paper medical records were less reliable due to missing data. Conclusion: Detailed characteristics of community-dwelling PU patients can be derived from routinely collected data, and provides various forms and levels of information which could feed into different projects. The use of mandatory reporting fields increases the level of reporting and reduces missing data. Data enriched with information from electronic and paper records could inform the addition of variables to mandatory forms to improve characterisation of community dwellers with PUs.
Predictive factors for category II pressure ulcers in older patients with hip fractures: a prospective study
Authors: Gazineo Domenica , Chiari Paolo , Chiarabelli Matteo , Morri Mattia , D'Alessandro Fabio , Sabattini Tania , Ambrosi Elisa , Forni Cristiana 
Published: September 2019

Objective: To identify the incidence of category II or higher hospital-acquired pressure ulcers (HAPU) and significantly associated factors in older patients with hip fractures. PUs are a frequent complication in hip fracture patients, negatively impacting patients' quality of life, the health-care system and society. Method: A prospective cohort study was conducted. A consecutive sample of patients with pertrochanteric, femoral neck or subtrochanteric fractures requiring surgical treatment, were included. A stepwise, multiple regression was performed to identify factors associated with PU development. Results: A total of 761 patients aged ≥65 years were sampled. The incidence of category II or higher PUs was 12%. The study identified five factors that were significantly, independently associated with category II or higher PU development, including a higher preoperative Braden score (Hazard Ratio [HR]: 0.884; 95% confidence interval [CI]: 0.806–0.969), surgical procedure with osteosynthesis (HR 1.876; 95%CI: 1.183–2.975), a higher percentage of days with the presence of foam valve before surgery (HR: 1.010; 95%CI: 1.010–1.023) and a urinary catheter (HR: 1.013; 95%CI: 1.006–1.019) and diaper (HR: 1.007; 95% CI 1.001–1.013) in the postoperative period. Conclusion: Attention should be given by clinical staff to avoiding the use of foam valves, to limiting the use of diapers and to early removal of urinary catheters.
Biofilm management using monofilament fibre debridement technology: outcomes and clinician and patient satisfaction
Authors: Roes Claas , Calladine Leanne , Morris Clare 
Published: September 2019

Objective: Best practice in wound bed preparation and biofilm-based wound management includes debridement to create a clean wound bed and to assist in minimising the redevelopment of biofilm. Biofilm that is not removed inhibits healing and redevelops if not prevented from doing so with topical antimicrobial agents. Monofilament fibre debriding technology (MFDT) is used for effective and rapid mechanical debridement of loose material, slough and biofilm. The objective of this evaluation was to determine the clinical effect and consequential levels of health professional and patient satisfaction with the results of a biofilm pathway that included MFDT to achieve debridement. Methods: This non-comparative, open label evaluation was conducted in static and non-static wounds that required debridement. MFDT was used to debride in a two-week evaluation of a biofilm pathway. Wounds were debrided three times in week one and twice in week two. Each debridement was followed by treatment with an antimicrobial dressing. Other care included secondary dressings and compression delivered according to local practice, guidelines and formularies. After the clinical evaluation, health professionals were invited to complete an online survey of the clinical outcomes and their satisfaction with the biofilm pathway. Results: There were 706 health professionals who provided answers to the survey questions. Wound types evaluated were leg ulcers (67.4%), pressure ulcers (10%), dehisced surgical wounds (1.7%), diabetic foot ulcers (7.4%) and other wounds (13.4%). Of the wounds, 9% were reported as non-static despite the eligibility criteria. Not all wounds followed the pathway. The most frequently-used antimicrobial was silver. Non-antimicrobial products used included all-in-one dressings, other secondary dressings and compression. There was a change in 77% of wounds overall after two weeks. Change was reported almost equally for both static and non-static wounds. Health professionals who did or did not follow the pathway were ‘completely satisfied’ or ‘satisfied’ with the overall clinical outcome 96% and 95%, respectively. Of the patients, 77% were ‘completely satisfied’ or ‘satisfied’ with healing after following the pathway, as reported by the treating health professional. Conclusion: The biofilm pathway that includes MFDT appears effective. Wounds managed on the pathway were debrided effectively and healing progressed to the satisfaction of both health professionals and patients.
REFLEXÕES SOBRE OS TEMAS DE GÊNERO, ETNIA E DIVERSIDADE SEXUAL NA FORMAÇÃO DOCENTE ATRAVÉS DA TEORIA DO IMAGINÁRIO SOCIAL
Authors: Machado Gabriella Eldereti , Oliveira Valeska Maria Fortes de 
Published: September 2019

Este artigo se propõe com base nos estudos de Cornelius Castoriadis sobre Imaginário Social discutir e aproximar-se da relação entre o instituído e instituinte para problematizar as questões de gênero e diversidade sexual na formação de professores. No qual serão abordados aspectos referentes à constituição da sociedade e sua dinâmica nas instituições sociais por meio do Imaginário Social, refletindo sobre as relações de representação de gênero, etnia e diversidade constituintes do modo que cada indivíduo se relaciona com o outro e com o mundo.
TOMBOY: POTENCIALIDADE PARA PROBLEMATIZAR GÊNERO E SEXUALIDADE
Authors: Silva Apolonia de J. Ferreira 
Published: September 2019

O presente trabalho busca discutir e problematizar a produção discursiva dos sujeitos e a sua relação com as subjetividades, pensando os discursos que circunscrevem as relações de gênero e as sexualidades e que organizam o filme Tomboy[1]. Apresenta como aporte teórico a perspectiva Pós-estrutulalista, os estudos Foucaltianos, assim como os estudos sobre a cultura visual. Nesse sentido consideramos importante refletir acerca dos processos de enquandramento e resistência, entendendo-os como possibilidades educativas de pensar o ser diferente.PALAVRAS-CHAVE: Cinema. Educação. Gênero. Sexualidade.[1] Tomboy, da diretora Céline Sciamma, é um longa-metragem, produzido no ano de 2012. Apresenta como atriz principal, Laure, uma criança de dez anos, biologicamente feminina, mas que parece se sentir, vestir e agir como pertencente ao gênero masculino.
Karakterisasi Lemak Sapi dan Lemak Babi dalam Bakso Menggunakan FTIR Spectroscopy
Authors: Lora Buana Dienda , Fajriati Imelda 
Published: September 2019

Karakterisasi lemak sapi dan lemak babi menggunakan spektroskopi infra merah dilakukan untuk mengetahui profil khas spektra lemak sapi dan lemak babi menggunakan FTIR Spectroscopy, sekaligus mengetahui kemungkinan cemaran lemak babi dalam bakso. Sampel bakso terlebih dahulu di ekstraksi Soxhlet menggunakan pelarut n-heksan dan petroleum eter, serta variasi waktu ekstraksi selama 2 jam, 3 jam, dan 4 jam untuk mendapatkan rendemen ekstraksi optimum. Hasil ekstraksi selanjutnya diidentifikasi profil spektranya menggunakan FTIR. Rendemen ekstraksi terbanyak didapatkan dengan waktu ekstraksi 2 jam menggunakan pelarut petroleum eter. Hasil karakterisasi dengan FTIR menunjukkan bahwa spektra lemak sapi dan lemak babi sedikit menunjukkan perbedaan pada 3000 – 3010 cm-1, 1172 cm-1 dan 1103 cm-1, dan 960 - 975 cm-1 yang diakibatkan antara lain dari asam lemak trans pada sampel lemak sapi lebih besar daripada lemak babi. Adapun dari sampel bakso yang di uji, sejauh hasil karakterisasi menggunakan pembanding spektra FTIR dari standar lemak babi, tidak didapatkan cemaran lemak babi dalam sampel bakso. Kata kunci: Ekstraksi Soxhlet, lemak sapi dan lemak babi.
PERAN TIPE GAMBAR, TAGAR, JUMLAH LIKES DAN INFORMASI HARGA PADA INSTAGRAM TERHADAP INTENSI MEMBELI
Authors: Sari Hasrini , Anggraeni Lidia 
Published: September 2019

Penelitian ini bertujuan untuk mengetahui pengaruh desain visual post Instagram dalam hal tipe gambar, tagar, jumlah likes, dan caption berupa informasi harga, terhadap tingkat atensi visual pemirsa, dan intensi pembelian. Keempat elemen tersebut dihipotesiskan akan mempengaruhi atensi visual pemirsa, dan pada akhirnya mempengaruhi intensi membeli. Metode desain eksperimen digunakan untuk menguji hipotesis dengan alat bantu eye tracker untuk mengukur atensi visual. Instagram dari sebuah perusahaan UKM yang menjual tas tangan (pouch) digunakan sebagai objek penelitian. Delapan stimulus berpasangan (gambar produk dan konsumen) yang merupakan dummy post Instagram dirancang berdasarkan hipotesis penelitian, dan satu pasang stimulus post Instagram yang ada saat ini digunakan sebagai kontrol. Empat puluh partisipan dipaparkan kesembilan stimulus menggunakan pendekatan within subject design. Dari hasil statistik deskriptif, ditemukan bahwa partisipan lebih menyukai tipe gambar produk, dan stimulus yang paling disukai yang menampilkan caption keterangan harga, hashtag serta jumlah likes yang banyak. Uji statistik inferensial menunjukkan adanya perbedaan tipe gambar (gambar produk dan gambar konsumen) dan jumlah likes mempengaruhi tingkat atensi visual pemirsa, serta tidak ada hubungan antara tingkat atensi terhadap tampilan Instagram dengan intensi membeli. Abstract[Role Of Image Type, Hashtag, Number Of Likes And Pricing Information On Instagram Against Intensi Buying] This research is intended to investigate the influence of visual design of Instagram concerning picture type, hashtag, number of likes, and price information, on intention to buy. These elements are suggested to influence visual attention of the audience, and ultimately influence the intention to buy. Experiment design method is implemented to test the hypotheses using an eye tracker device to measure visual attention. An Instagram post from an SME offering pouch is used as a research object. Eight paired of dummy Instagram posts (the product picture and the consumer picture) are designed to test the research hypotheses, and a pair of existing Instagram post acts as a control stimulus. Forty participants are exposed to all of the stimuli using a within-subject design approach. Descriptive statistic analysis shows that participants like product picture more than consumer, and stimulus containing price information, hashtag, and many likes. Inferential statistic analysis shows that picture type and likes all influence visual attention and no significant relationship between visual attention and intention to buy.Keywords: Intention to buy; visual attention; statistic inferensia; desain eksperimen
Global well-posedness for a class of fourth-order nonlinear strongly damped wave equations
Authors: Lian Wei , Rădulescu Vicenţiu D. , Xu Runzhang , Yang Yanbing , Zhao Nan 
Published: September 2019

Abstract
In this paper, we consider the initial boundary value problem for a class of fourth-order wave equations with strong damping term, nonlinear weak damping term, strain term and nonlinear source term in polynomial form.
First, the local solution is obtained by using fix point theory.
Then, by constructing the potential well structure frame, we get the global existence, asymptotic behavior and blowup of solutions for the subcritical initial energy and critical initial energy respectively.
Ultimately, we prove the blowup in finite time of solutions for the arbitrarily positive initial energy case.
Ricci almost solitons and contact geometry
Authors: Ghosh Amalendu 
Published: September 2019

Abstract
We prove that on a K-contact manifold, a Ricci almost soliton is a Ricci soliton if and only if the potential vector field V is a Jacobi field along the Reeb vector field ξ. Then we study contact metric as a Ricci almost soliton with parallel Ricci tensor. To this end, we consider Ricci almost solitons whose potential vector field is a contact vector field and prove some rigidity results.
A Simple and Procedurally Fair Game Form for Nash Implementation of the No-Envy Solution
Authors: Hagiwara Makoto 
Published: September 2019

Abstract
We consider the allocation problem of infinitely divisible resources with at least three agents. For this problem, Thomson (Games and Economic Behavior, 52: 186-200, 2005) and Doğan (Games and Economic Behavior, 98: 165-171, 2016) propose “simple” but not “procedurally fair” game forms which implement the “no-envy” solution in Nash equilibria. By contrast, Galbiati (Economics Letters, 100: 72-75, 2008) constructs a procedurally fair but not simple game form which implements the no-envy solution in Nash equilibria. In this paper, we design a both simple and procedurally fair game form which implements the no-envy solution in Nash equilibria.