bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unilateral temporal interictal epileptiform discharges correctly predict the epileptogenic zone in lesional temporal lobe epilepsy
Authors: Vollmar Christian , Stredl Iris , Heinig Matthias , Noachtar Soheyl , Rémi Jan 
Published: July 2018

SummaryObjectiveTo evaluate the necessity of recording ictal electroencephalography (EEG) in patients with temporal lobe epilepsy (TLE) considered for resective surgery who have unilateral temporal interictal epileptiform discharges (IEDs) and concordant ipsitemporal magnetic resonance imaging (MRI) pathology. To calculate the necessary number of recorded EEG seizure patterns (ESPs) to achieve adequate lateralization probability.MethodsIn a retrospective analysis, the localization and lateralization of interictal and ictal EEG of 304 patients with lesional TLE were analyzed. The probability of further contralateral ESPs was calculated based on a total of 1967 recorded ESPs, using Bayes’ theorem.ResultsTwo hundred seventy‐one patients had unilateral TLE, and in 98% of them (265 of 271), IEDs were recorded during video‐EEG monitoring. Purely unilateral temporal IEDs were present in 61% (166 of 271 patients). Ipsilateral temporal MRI pathology was found in 83% (138 of 166). Ictal EEG was concordant with the clinical side of TLE in 99% (136 of 138) of these patients. Two patients had discordant ictal EEG with both ipsilateral and contralateral ESPs. Epilepsy surgery with resection in the lesioned temporal lobe was still performed, and both patients remain seizure‐free. Probability calculations demonstrate that at least 6 recorded unilateral ESPs result in a >95% probability for a concordance of >0.9 of any further ESPs.SignificanceThe combination of purely unilateral temporal IED with ipsitemporal MRI pathology is sufficient to identify the epileptogenic zone, and the recording of ictal ESP did not add any surgically relevant information in these 138 patients. Rarely, discordant ESPs might be recorded, but the surgical outcome remains excellent after surgery on the lesioned side.
Seizure duration and latency of hypermotor manifestations distinguish frontal from extrafrontal onset in sleep‐related hypermotor epilepsy
Authors: Gibbs Steve A. , Proserpio Paola , Francione Stefano , Mai Roberto , Cossu Massimo , Tassi Laura , Nobili Lino 
Published: July 2018

SummarySleep‐related hypermotor epilepsy (SHE) is an epilepsy syndrome that is characterized by the occurrence of sleep‐related hypermotor seizures of variable complexity and duration. Seizures usually arise in the frontal lobe, but extrafrontal seizure onset zones are well described. To identify clinically relevant ictal features of SHE that could distinguish a frontal from an extrafrontal onset zone, we conducted a retrospective analysis of seizure characteristics in 58 patients with drug‐resistant SHE (43 frontal and 15 extrafrontal) who underwent video‐stereo‐electroencephalographic recordings and became seizure‐free after epilepsy surgery. We found that the mean duration of electrographic seizures and clinically observable ictal manifestations were significantly shorter in frontal SHE compared to extrafrontal SHE. The mean latency between electrographic seizure onset and the onset of hypermotor manifestations was also shorter in frontal SHE. Accordingly, a latency > 5 seconds between the first video‐detectable movement (eg, eye opening or a minor motor event) and the onset of hypermotor manifestations yielded a sensitivity of 75% and a specificity of 90% for an extrafrontal onset, thereby indicating that specific ictal features in SHE can provide clinically useful clues to increase diagnostic accuracy in this syndrome.
National Culture and Takeover Contest Outcomes
Authors: Blomkvist Magnus , Felixson Karl , Korkeamäki Timo 
Published: July 2018

AbstractWe examine the effects of cultural differences on the outcome of takeover contests. Our main focus is on individuality, which we posit to have an effect on firm behavior in international takeover contests. In a sample of international acquisitions with bidders from multiple countries, we find that individuality positively relates to the probability of placing the winning bid. We further find that takeover contest winners with high individuality scores experience lower announcement returns. Our results are consistent with the literature that links individuality to overconfidence. Our evidence suggests that firms should control culture‐related behavioral biases in their mergers and acquisitions activity.
A Dynamic Model of Firm Valuation
Authors: Lazzati Natalia , Menichini Amilcar A. 
Published: July 2018

AbstractWe propose a dynamic version of the dividend discount model, solve it in closed form, and assess its empirical validity. The valuation method is tractable and can be easily implemented. We find that our model produces equity value forecasts that are very close to market prices, and explains a large proportion of the observed variation in share prices. Moreover, we show that a simple portfolio strategy based on the difference between market and estimated values earns considerably positive returns. These returns cannot be simply explained either by the Fama‐French three‐factor model (even after adding a momentum factor) or the Fama‐French five‐factor model.
Investor Recognition and Post‐Acquisition Performance of Acquirers
Authors: Cui Di 
Published: July 2018

AbstractThe literature has documented a negative relation between investor recognition and expected returns. This negative relation is consistent with the prediction in Merton (1987, Journal of Finance 42, 483–510). This paper investigates whether the changes in investor recognition of acquirers around the time of the acquisitions can explain the post‐acquisition underperformance of acquirer stocks. Using a large sample of U.S. acquisitions from 1980 to 2010, this paper finds that investor recognition, proxied by the number of institutional investors and the number of common shareholders, increases significantly during acquisitions. Once the increases in investor recognition are controlled for, the “puzzling” long‐run underperformances of acquirers disappears.
The Wealth Effects of Fairness Opinions in Takeovers
Authors: Liu Tingting 
Published: July 2018

AbstractThis paper explores the wealth effects associated with a bidder's decision to solicit a fairness opinion in a takeover transaction. Using a hand‐collected sample with bidders’ filing proxy statements, this paper finds that the use of fairness opinions does not negatively affect bidder shareholders’ wealth, a finding that contradicts prior studies’ findings. In addition, I find a positive wealth effect associated with bidder use of fairness opinions in the post‐Rule 2290 period. Collectively, these results are consistent with a fairness opinion being used by bidder management as a means to facilitate transactions rather than a mechanism to entrench management.
Reasons for Manuscript Rejection After Peer Review From the Journal Headache
Authors: Hesterman Chelsea M. , Szperka Christina L. , Turner Dana P. 
Published: July 2018

ObjectiveTo identify and characterize the reasons manuscripts are rejected after peer review from the journal Headache.BackgroundNumerous editorials, reviews, and research manuscripts have been published on the topic of manuscript rejection. However, few of these papers evaluate the reasons for rejection after peer review systematically. None are specific to the field of neurology or headache medicine.MethodsA retrospective analysis of all submissions to Headache from January 1, 2014 through December 31, 2016 was performed. Peer reviewer and editor comments for each manuscript were reviewed, and unlimited reasons for rejection were coded for each manuscript. Detailed reasons for rejection were then grouped into 9 broader categories.ResultsA total of 784 submissions were received from January 1, 2014 through December 31, 2016. Of those, 336 were immediately rejected and 434 went on to peer review. During this period, the overall rejection rate was 62.6% and the rejection rate after peer review was 35.7%. The 6 most common reasons for rejection after peer review were: flaws in methodology and study design, poor reporting of methodology, poor statistical analysis, overstatement of conclusions, problems with covariates or outcomes, and problems with the control or case group.ConclusionFlaws in methodology and study design were the most common reasons for rejection after peer review from Headache between 2014‐2016.
Diet of Neotropical parrots is independent of phylogeny but correlates with body size and geographical range
Authors: Benavidez Analia , Palacio Facundo Xavier , Rivera Luis Osvaldo , Echevarria Ada Lilian , Politi Natalia 
Published: July 2018

Body mass and geographical range are two main drivers of diet in animals, yet how these factors influence diet in the morphologically and ecologically diverse avian group of Psittaciformes is little known. We reviewed current knowledge of the diet of Neotropical parrots and assessed the relation between diet (breadth and composition), phylogeny, body mass and geographical range. Diet has been documented for 98 of 165 species, but information is available only for 34 of 59 threatened species, and countries with high species diversity (> 20 species) had few studies (one to seven). Neotropical parrot species consumed 1293 plant species of 125 families. When assessing the relative frequency of different food items in the diet (seed, fruits, flowers, leaves, nectar, bark and stems), we found that parrots mostly exploited seeds (41.9%) and fruits (38.3%) of native species. Diet overlap was very low among genera (0.006–0.321). At the species level, geographical range and body size explained the variation in diet composition. In particular, small parrots of restricted distribution had a distinct diet composition relative to either large or widely distributed species. Although body size and geographical range showed phylogenetic inertia, diet was independent of phylogenetic history. Our review not only reveals ecological factors explaining diet in a generalist group but also exposes information gaps across the Neotropical region.
Pemphigus herpetiformis in South Tunisia: a clinical expression of pemphigus foliaceus?
Authors: Jerbi Ameni , Hachicha Hend , Feki Sawsan , Bahloul Emna , Sellami Khadija , Abida Olfa , Charfi Slim , Bouzid Amina , Sellami Boudawara Tahia , Turki Hamida , Masmoudi Abderrahmen , Masmoudi Hatem 
Published: July 2018

AbstractBackgroundPemphigus herpetiformis (PH) is a rare subtype of pemphigus combining clinical features of dermatitis herpetiformis and the immunopathologic characteristics of pemphigus. We aimed to analyze the epidemiological, clinical, and immunological presentation and management of the disease in a cohort of south Tunisian patients with a long‐term follow‐up.MethodsWe included all patients with confirmed PH followed from January 1987 to December 2015 in the dermatology department.ResultsWe included 24 south Tunisian female patients with a mean age of 36 years (20–63), mainly from rural origin (84%). All patients had exclusive skin lesions. Clinical features combined erythematous, vesicular, or bullous lesions, with circinate borders mainly on the trunk and limbs associated with severe pruritus (91%). Peripheral hypereosinophilia was noted in 31% of cases. Histological examination demonstrated no intraepithelial (50%), suprabasal (35%), or subcorneal cleavage (15%). Eosinophilic spongiosis was seen in 42% of cases. On direct immunofluorescence, there was an intercellular staining in 96% of cases composed mainly of IgG and C3 (79%). Indirect immunofluorescence was positive in 71% of cases. Reactivity was mainly directed against Dsg1. Dapsone alone was inefficient. All patients received systemic corticosteroids. Most patients (64%) relapsed. Iatrogenic complications and cutaneous infections were noted in 40% and 16% of cases, respectively.ConclusionPH is characterized by the occurrence of exclusive skin lesions in young women with a good response to corticosteroids but not to Dapsone. Reactivity mainly against Dsg1 suggests that PH in south Tunisia is a particular variant of nonendemic pemphigus foliaceus.
Current strategies exploiting NK‐cell therapy to treat haematologic malignancies
Authors: Johnson Jenna K. , Miller Jeffrey S. 
Published: July 2018

AbstractNatural killer (NK) cells recognize targets that have been changed via malignant transformation or infection. Previously, NK cells were thought to be short‐lived, but we now know that NK cells can be long‐lived and remember past exposures in response to CMV. NK cells use a plethora of activating and inhibitory receptors to recognize these changes and attack targets, but tumour cells often evade NK cells. Therefore, major efforts are being made to hone in on NK cell antitumour properties in immunotherapy. In the clinical setting, haploidentical NK cells can be adoptively transferred to help treat cancer. To expand NK cells in vivo and enhance tumour targeting, IL‐15 is being tested in combination with a glycogen synthase kinase (GSK) 3 inhibitor (CHIR99021), an inhibitor that has been shown to expand mature, highly functional NK cells capable of killing multiple tumour targets. One major limitation to NK cell therapy is lack of specificity. To address this concern, bispecific or trispecific engagers that target NK cells to the tumour and an ADAM17 inhibitor that prevents CD16 shedding after NK cell activation are being tested. Additionally, monoclonal antibodies are being designed to redirect the inhibitory signals that limit NK cell functionality. Further understanding of the biology of NK cells will inform strategies to exploit NK cells for therapeutic purposes.
The POMONA‐ESP project methodology: Collecting data on health indicators for people with intellectual developmental disorders
Authors: Folch Annabel , Martínez‐Leal Rafael , Vicens Paloma , Irazábal Marcia , Muñoz Silvia , Salvador‐Carulla Luis , Rovira Lluís , Orejuela Carmen , Cortés Maria José 
Published: July 2018

AbstractBackgroundPeople with intellectual developmental disorders have significant health disparities and a lack of proper attention to their health needs. They have been underrepresented in scientific research, and very few studies have been carried out using a representative randomized sample. The aim of this study was to describe the methods used in the POMONA‐ESP project to recruit a representative and randomized sample of participants with intellectual developmental disorders.MethodsThe POMONA‐ESP project is an observational cross‐sectional study. It aims to explore the health status of people with intellectual developmental disorders across Spain and the use they make of health services.Results and conclusionsThe results of the POMONA‐ESP project may have a major impact on people with intellectual developmental disorders and society in general. It is the first study to obtain geographically representative epidemiological data from a large sample, information that is fundamental to improving care and healthcare planning for people with intellectual developmental disorders.
Dipalmitoylphosphatidic acid inhibits breast cancer growth by suppressing angiogenesis via inhibition of the CUX1/FGF1/HGF signalling pathway
Authors: Chen Jian , Zhou Zijun , Yao Yuying , Dai Jianwei , Zhou Dalei , Wang Lijing , Zhang Qian‐Qian 
Published: July 2018

AbstractTumour growth depends on a continual supply of the nutrients and oxygen, which are offered by tumour angiogenesis. Our previous study showed that dipalmitoylphosphatidic acid (DPPA), a bioactive phospholipid, inhibits the growth of triple‐negative breast cancer cells. However, its direct effect on angiogenesis remains unknown. Our work showed that DPPA significantly suppressed vascular growth in the chick embryo chorioallantoic membrane (CAM) and yolk sac membrane (YSM) models. Meanwhile, tumour angiogenesis and tumour growth were inhibited by DPPA in the tumour tissues of an experimental breast cancer model, a subcutaneous xenograft mouse model and a genetically engineered spontaneous breast cancer mouse model (MMTV‐PyMT). Furthermore, DPPA directly inhibited the proliferation, migration and tube formation of vascular endothelial cells. The anti‐angiogenic effect of DPPA was regulated by the inhibition of Cut‐like homeobox1 (CUX1), which transcriptionally inhibited fibroblast growth factor 1 (FGF1), leading to the downregulation of hepatocyte growth factor (HGF). This work first demonstrates that DPPA directly inhibits angiogenesis in cancer development. Our previous work along with this study suggest that DPPA functions as an anti‐tumour therapeutic drug that inhibits angiogenesis.
The evolution of GRADE (part 1): Is there a theoretical and/or empirical basis for the GRADE framework?
Authors: Mercuri Mathew , Gafni Amiram 
Published: July 2018

AbstractRationale, aims, and objectivesThe Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) framework has been presented as the best method available for developing clinical recommendations. GRADE has undergone a series of modifications. Here, we present the first part of a three article series examining the evolution of GRADE. Our purpose is to explore if (and if so, how) GRADE provides: (1) a justification (ie, theoretical and/or empirical) for why the criteria/components under consideration in the system are included (and other factors excluded), as well as why some criteria/components where added/modified in the evolution process, (2) clear and functional (ie, how to operationalize them) definitions of the included criteria/components, and (3) instruction and justification for how all the criteria/components are to be integrated when determining a recommendation. In part 1 of the series, we examine the first two versions of GRADE.MethodsNarrative review.ResultsThe justification scheme that sustains GRADE is not articulated in the first two versions of the framework. Why some criteria/components were included, and others excluded, is not justified theoretically nor is empirical support provided to suggest that the framework as presented includes that which is needed to produce valid recommendations. The first two versions of GRADE show a lack of clear instruction on how to operationalize the criteria for assessing the quality of evidence and the components for making a recommendation (including how to integrate the criteria/components at each step), which leaves substantial room for judgement on the part of the user of GRADE for guideline development.ConclusionsThis article revealed an absence of a justification (theoretical and/or empirical) to support important aspects of the GRADE framework, as well as a lack of clear instruction on how to operationalize the criteria and components in the framework. These issues limit one's ability to scientifically assess the appropriateness of GRADE for determining clinical recommendations.
Interplay Between Sensation Seeking and Parental Rules in the Emergence of Heavy Episodic Drinking
Authors: Percy Andrew , McKay Michael T. , Cole Jon C. 
Published: July 2018

This study examined the parallel mediational processes between sensation seeking and parental rules on alcohol, in the emergence of heavy episodic drinking (HED) in adolescents. Data were drawn from a U.K. clustered randomized control trial (control arm only, N ≈ 6,300, Mage at baseline = 12.5). Using parallel process latent growth curve analysis, stricter parental rules at baseline were found to be associated with greater declines in sensation seeking over time and a lower risk of HED at follow‐up (+33 months). Higher initial levels of sensation seeking predicted a faster relaxation of parental rules and a greater risk of HED. By maintaining strict rules about alcohol, parents may promote a positive reduction in sensation seeking and a lower risk of HED.
Peel meals as feed ingredients in poultry diets: Chemical composition, dietary recommendations and prospects
Authors: Diarra Siaka S. 
Published: July 2018

AbstractThe increase demand for poultry products has had direct effect on the supply and price of feed. This has increased research interest into the potential of locally available, less competed and low cost materials as feed ingredients. Several peels from roots/tubers and fruits have been evaluated in poultry diets but recommendations have not been consistent. High fibre, low nutrient density and likely presence of antinutritional factors limit the efficient utilisation of peel meal by poultry. Plant cultivar, age, agronomic practices, method of peel processing, breed and age of poultry all affect the inclusion level of peel meal in poultry diets. The increase interest in breeding crops for low antinutrients, knowledge in processing technologies and availability of several additives such as enzyme products, amino acids and antinutrients binding agents in the feed market could improve the usefulness of peel meal in on‐farm poultry rations. This study reviews the potential of selected root/tuber and fruit peels as feed ingredients for poultry with regards their composition, dietary recommendation and prospects.
Clinical characteristics of self‐reported nocturia in patients with interstitial cystitis, and effects of bladder hydrodistention (with fulguration of Hunner lesions) on nocturia
Authors: Otsuka Atsushi , Suzuki Takahisa , Aki Ryota , Matsushita Yuto , Tamura Keita , Motoyama Daisuke , Ito Toshiki , Sugiyama Takayuki , Miyake Hideaki 
Published: July 2018

ObjectiveThe aim of this study was to investigate the clinical characteristics of nocturia in patients with interstitial cystitis (IC), and the effects of bladder hydrodistention (with fulguration of Hunner lesions) on nocturia.MethodsThe records of 81 patients who were diagnosed with IC were reviewed. Clinical characteristics were evaluated using the Interstitial Cystitis Symptom Index (ICSI), a visual analogue scale (VAS), and bladder diary data. Differences in characteristics between Hunner‐ and non‐Hunner‐type IC were compared. Correlations between nocturia and other clinical variables were assessed. Stepwise multiple regression analysis was performed to identify factors associated with nocturia. Further, changes in nocturia before and after hydrodistention (with fulguration of Hunner lesions) were analyzed.ResultsThe mean (± SD) age of patients was 62.2 ± 15.3 years. Significant differences in nocturia were observed between Hunner‐ and non‐Hunner‐type IC. Nocturia was positively correlated with age, urgency score (ICSI and VAS), mean number of urgency episodes per 24 hours and the nocturnal polyuria (NP) index, and negatively correlated with average voided volume. Age, NP index, average voided volume, and the presence of Hunner lesions were independent factors associated with nocturia. Bladder hydrodistention significantly decreased nocturia in non‐Hunner type IC without NP. In addition, regardless of the presence or absence of NP, bladder hydrodistention with fulguration of Hunner lesions significantly decreased nocturia in Hunner‐type IC.ConclusionsThe severity of nocturia is associated with age, NP, average voided volume, and the presence of Hunner lesions in IC patients. Bladder hydrodistention (with fulguration of Hunner lesions) has the potential to decrease nocturia.