bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrogenic effects of fluorinated diiodine alkanes in MCF‐7 cells, H295R cells and zebrafish embryo assays
Authors: Lu Liang , Chang Jia , Qiu Yunliang , Chang Yan , Ma Jing 
Published: March 2019

AbstractFluorinated diiodine alkanes (FDIAs), important industrial intermediates in the synthesis of various perfluorinated compounds, which are distributed widely in wildlife and humans. Recent studies showed that FDIAs had in vitro estrogenic effects. However, to date, little information is available regarding the in vivo estrogenic effects of FDIAs and the mechanisms are unclear. In this study, a combination of in vitro and in vivo assays was used to investigate the estrogenic effects of FDIAs. We tested the in vitro estrogenic effects and estrogen receptor‐related gene expression via MCF‐7 cell assay. The hormone level of estradiol and the expression of estrogenic synthesis genes were measured in the H295R cell assay. Finally, the in vivo effects of FDIAs on development and estrogen‐related gene expression were assessed in the zebrafish embryos assay. The results demonstrated that FDIAs could exhibit estrogenic activity through inducing cell proliferation (1.6‐6.7‐fold of the control) and estrogen receptor alpha gene expression (1.07‐1.39‐fold of the control), altering estradiol production (1.14‐1.22‐fold of the control) and the major estrogenic synthesis gene expression of CYP19 (1.22‐1.31‐fold of the control), disrupting the estrogen‐related genes (esr1 and cyp19b) levels in zebrafish (1.52‐2.99‐fold and 2.95‐5.00‐fold of the control for esr1 and cyp19b, respectively). The current findings indicated the potential estrogenic effects of FDIAs and provided novel information for human risk assessment.
In vitro oxidative stability of high strength siloxane poly(urethane‐urea) elastomers based on linked‐macrodiol
Authors: Dandeniyage Loshini S. , Knower Warren , Adhikari Raju , Bown Mark , Shanks Robert , Adhikari Benu , Gunatillake Pathiraja A. 
Published: March 2019

AbstractIn vitro oxidative stability of two siloxane poly(urethane urea)s synthesized using 4,4′‐methylenediphenyl diisocyanate (in SiPUU‐1) and Isophorone diisocyanate (in SiPUU‐2) linked soft segment was evaluated using 20% H2O2 and 0.1 mol/L CoCl2 solution at 37°C under 150% strain. Commercially available siloxane polyurethane (Elast‐Eon™ 2A) and polyether polyurethane (ChronoThane P™ 80A) were used as negative and positive controls, respectively. ChronoSil™ 80A was included as another commercially available polycarbonate polyurethane. Scanning electron microscopic (SEM) examinations, attenuated total reflectance‐Fourier transform infrared (ATR‐FTIR) spectroscopy, and molecular weight reduction revealed the extensive degradation of ChronoThane P™ 80A after 90 days while SiPUU‐1, SiPUU‐2 and Elast‐Eon™ 2A showed no noticeable surface degradation. ChronoSil™ 80A showed degradation in both soft and hard segments. Tensile testing was carried out only on unstrained polyurethanes for 90 days. ChronoThane P™ 80A showed 35% loss in ultimate tensile strength and it was only 13–14% for SiPUU‐1 and Elast‐Eon™ 2A. However, the tensile strength of ChronoSil™ 80A was not significantly affected. The results of this study proved that SiPUU‐1 possess oxidative stability comparable with Elast‐Eon™ 2A. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2557–2565, 2019.
ANRIL and ANRASSF1 long noncoding RNAs are upregulated in gastric cancer
Authors: Kangarlouei Roghayeh , Irani Shiva , Noormohammadi Zahra , Memari Fereidoon , Mirfakhraie Reza 
Published: March 2019

AbstractGastric cancer (GC) is the fifth most frequent cancer and the third‐leading cause of cancer‐related death worldwide. It is a highly heterogeneous disease regarding the morphological and molecular viewpoints. Since it is curable in primary stages, early detection could improve the survival rate. Long noncoding RNAs contribute to a variety of cellular mechanisms, and their dysregulation is reported in various diseases such as cancer. Thus, they have a great potential to be used as diagnostic and prognostic biomarkers and therapeutic targets as well. In the current study, ANRIL and
ANRASSF1 expression levels were compared between GC tumors and the adjacent normal tissues collected from 39 Iranian patients using the quantitative real‐time polymerase chain reaction method. Correlation between
ANRIL and
ANRASSF1 expression levels and other clinical parameters was also evaluated.
ANRIL and
ANRASSF1 were significantly overexpressed in GC tumors compared with adjacent tissues (
P < 0.0001 and
P = 0.001, respectively). No significant correlation between
ANRIL and
ANRASSF1 expression levels and demographic information was found. This study suggests that
ANRIL and
ANRASSF1 may play a critical role in GC progression and can be considered as a potential diagnostic or therapeutics biomarkers.
New necessary conditions on Paley‐type partial difference sets in abelian groups
Authors: Wang Zeying 
Published: March 2019

AbstractLet be an abelian group of order , where are distinct odd prime numbers. In this paper, we prove that if contains a regular Paley‐type partial difference set (PDS), then for any is congruent to 3 modulo 4 whenever is odd. These new necessary conditions further limit the specific order of an abelian group in which there can exist a Paley‐type PDS. Our result is similar to a result on abelian Hadamard (Menon) difference sets proved by Ray‐Chaudhuri and Xiang in 1997.
Latino parents' links to deportees are associated with developmental disorders in their children
Authors: Vargas Edward D. , Benitez Viridiana L. 
Published: March 2019

AbstractAimsTo examine how Latino parent's personal connection to immigrants is linked to their children's risk of being referred/diagnosed with a developmental disorder.MethodsUsing the 2015 Latino National Health and Immigration Survey (n = 548), we asked adults about their connections to immigrants. We also asked if their child has been referred/diagnosed with a developmental disorder. We estimated a series of regressions to predict increases in the probability of a child being referred/diagnosed for a developmental disorder.ResultsRespondents who know a deportee are 2.4 times more likely (p = 0.009) to report that their child has been referred or diagnosed with a developmental disorder. Additionally, knowing more deportees, and having a closer family tie with deportees, are all statistically associated with developmental problems.ConclusionsThis study adds to the emerging research on stress and child health, by examining the intersections of immigration policy, mental health, and child development.
Long noncoding RNAs biomarker‐based cancer assessment
Authors: Sarfi Mohammad , Abbastabar Maryam , Khalili Ehsan 
Published: March 2019

AbstractCancer diagnosis have mainly relied on the incorporation of molecular biomarkers as part of routine diagnostic tool. The molecular alteration ranges from those involving DNA, RNA, noncoding RNAs (microRNAs and long noncoding RNAs [lncRNAs]) and proteins. lncRNAs are recently discovered noncoding endogenous RNAs that critically regulates the development, invasion, and metastasis of cancer cells. They are dysregulated in different types of malignancies and have the potential to serve as diagnostic markers for cancer. The expression of noncoding RNAs is altered following many diseases, and besides, some of them can be secreted from the cells into the circulation following the apoptotic and necrotic cell death. These secreted noncoding RNAs are known as cell free RNA. These RNAs can be secreted from the cell through the apoptotic body, extracellular vesicles including microvesicle and exosome, and bind to proteins. Since, lncRNAs display high organ and cell specificity, can be found in the blood, urine, tumor tissue, or other tissues or bodily fluids of some patients with cancer, this review summarizes the most significant and up‐to‐date findings of research on lncRNAs involvement in different cancers, focusing on the potential of cancer‐related lncRNAs as biomarkers for diagnosis, prognosis, and therapy.
miR‐144‐3p facilitates nasopharyngeal carcinoma via crosstalk with PTEN
Authors: Song Li , Chen Lijie , Luan Qiang , Kong Qingdong 
Published: March 2019

AbstractAimsThis study aims to investigate the role of miR‐144‐3p and phosphatase and tensin homolog (PTEN) in nasopharyngeal carcinoma (NPC), along with their crosstalk with the phosphoinositide 3‐kinase (PI3K)–protein kinase B (Akt) pathway.MethodsQuantitative reverse transcription polymerase chain reaction and western blot were used to measure the gene expression at the transcriptional and translational levels. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay and colony formation assay were used to examine cell proliferation via standard protocol. Transwell assay was conducted to examine cell invasiveness. A flow cytometer was used to determine cell apoptosis. Dual‐Luciferase Reporter Gene Assay (SLDL‐100) was used to confirm the target relationship between miR‐144‐3p and PTEN. Xenografts were used to detect the in vivo effects of the molecules of interest.ResultsmiR‐144‐3p was significantly overexpressed, whereas PTEN was more underexpressed in tumor tissues than in adjacent tissues. miR‐144‐3p promoted the proliferation and invasion of NPC cells and inhibited apoptosis by directly targeting
PTEN, which improves PI3K–Akt signaling. miR‐144‐3p forced epithelial–mesenchymal transition in NPC.ConclusionmiR‐144‐3p promotes the progression of NPC by directly targeting PTEN via crosstalk with PI3K–Akt signaling.
The concept of load ratio applied to bioelectrochemical systems for ammonia recovery
Authors: Rodríguez Arredondo Mariana , Kuntke Philipp , ter Heijne Annemiek , Buisman Cees JN 
Published: March 2019

AbstractBACKGROUNDThe load ratio is a crucial parameter to optimize the current driven recovery of total ammonia nitrogen (TAN) from urine. The load ratio is the ratio between the current density and the TAN loading rate. It is currently not known if the load ratio concept applies to a bioelectrochemical system (BES) because the current density and TAN loading rate cannot be controlled independently.RESULTSWe found a clear increasing trend in TAN removal efficiency with respect to load ratio in the BES for both human and synthetic urine. The maximum TAN removal efficiency was 60.9% at a load ratio of 0.7, corresponding to a TAN transport rate of 119 gN m−2 day−1 at an electrical energy input of 1.9 kWh kgN−1 (synthetic urine). Low load ratios (<1) were obtained, indicating that the current was not enough to transport all the TAN across the membrane.CONCLUSIONSBES and ES show the same general relationship between TAN removal efficiency and load ratio. Therefore, given a stable current density, the concept of load ratio can also predict the TAN removal efficiency in BES. Higher current densities, and insights into the factors limiting current, are needed to increase the load ratio and therefore the TAN removal efficiency. © 2019 The Authors. Journal of Chemical Technology & Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Changes in Size and Sonographic Characteristics of the Adrenal Glands During the First Year of Life and the Sonographic Diagnosis of Adrenal Hyperplasia in Infants with 21‐Hydroxylase Deficiency
Authors: Menzel Daria , Hauffa Berthold P. 
Published: March 2019

The sonographic representation of developmental changes occurring in the normal adrenal gland during the first year of life was examined in 84 healthy newborns and infants. As a measure of adrenal size we chose a defined part of standardized adrenal sections, the adrenal size index (ASI). In newborns, ASI was high and decreased during the first year of life. Three different echo types were delineated, each one being predominant in a defined age group.ASI was markedly elevated in 5 patients with the salt‐wasting variety of 21‐hydroxylase deficiency, whereas in 3 patients without a severe salt loss, ASI was in the upper normal range. Although adrenal enlargement due to salt‐wasting 21‐hydroxylase deficiency can be recognized by determining ASI, other forms of 21‐hydroxylase deficiency do exist in which adrenal enlargement, detectable by ASI measurements, may not be present.
Ultrasonographic Difficulties and Pitfalls in Diagnosing Primary Carcinoma of the Gallbladder
Authors: Kuo Yow-Chii , Liu Jeng-Yaw , Sheen I-Shyan , Yang Chaur-Young , Lin Deng-Yn , ChangChein Chi-Sin 
Published: March 2019

In order to more specifically define gallbladder carcinoma with real‐time ultrasonography, a retrospective study was performed involving 29 sonographically false‐negative and 22 sonographically false‐positive cases of gallbladder carcinoma. Among the false negative cases, 18 (62.1%) were diagnosed as gallbladder stone only, 6 cases (20.7%) were incorrectly diagnosed as either acute or chronic cholecystitis, 2 cases (6.9%) were diagnosed as bile sludge, 2 cases (6.9%) were diagnosed as polyps, and 1 case (3.4%) was diagnosed as liver tumor. In false‐positive cases, 8 (31.8%) were erroneously diagnosed as liver tumor. In false‐positive cases, 7 (31.8%) were erroneously diagnosed as a mass projecting from the gallbladder wall but were pathologically proven to be polyps (4 cases) or bile sludge (3 cases); 8 cases (36.4%) were incorrectly diagnosed due to irregular thickening of the gallbladder wall but histology revealed them to be acute (3 cases) or chronic (5 cases) cholecystitis. Seven cases (31.8%) had a solid mass in porta hepatis, indicating gallbladder carcinoma; of these, 2 cases were lumps of bile sludge and 5 cases were acute cholecystitis with empyema.The differentiation of gallbladder carcinoma from cholecystitis (acute or chronic), polyps, and bile sludge is sometimes very difficult. With an understanding of the sanagraphic pitfalls and difficulties in the diagnosis of gallbaldder carcinoma, a more specific diagnosis may be made.
Ultrasonography of Carcinoma of the Gallbladder: An Analysis of 80 Cases
Authors: Kumar Alka , Aggarwal Shashi , Berry Manorama , Sawhney Sukhpal , Kapur Brij M.L. , Bhargava Sneh 
Published: March 2019

Eighty patients with primary carcinoma of the gallbladder were studied by ultrasonography. Two broad groups were defined. In group I (72.5%), the gallbladder lumen was identified along with a mass lesion, and in group II (27.5%), a large mass totally replacing the gallbladder was seen. Group I was further categorized into three subtypes according to the morphology of the lesion: type 1—a mass almost filling the lumen; type 2—a polypoidal mass projecting into the lumen; and type 3—an infiltrating mass. Associated findings of infiltration of the liver, presence of calculi, biliary tree obstruction, liver metastasis, and lymphadenopathy further supported the diagnosis.Ultrasonography was found to be highly reliable in the diagnosis of carcinoma of the gallbladder. In addition, it provided guidance for biopsy/aspiration of nonpalpable tumors. Its shortcomings appear to be its inability to assess peritoneal and bowel involvement, as well as that of the omentum and posterior rectus sheath.
Much ado about nothing: A qualitative study of the experiences of an average‐risk population receiving results of exome sequencing
Authors: Rego Shannon , Dagan‐Rosenfeld Orit , Bivona Stephanie A. , Snyder Michael P. , Ormond Kelly E. 
Published: March 2019

AbstractThe increasing availability of exome sequencing to the general (“healthy”) population raises questions about the implications of genomic testing for individuals without suspected Mendelian diseases. Little is known about this population's motivations for undergoing exome sequencing, their expectations, reactions, and perceptions of utility. In order to address these questions, we conducted in‐depth semi‐structured interviews with 12 participants recruited from a longitudinal multi‐omics profiling study that included exome sequencing. Participants were interviewed after receiving exome results, which included Mendelian disease‐associated pathogenic and likely pathogenic variants, pharmacogenetic variants, and risk assessments for multifactorial diseases such as type 2 diabetes. The primary motivation driving participation in exome sequencing was personal curiosity. While they reported feeling validation and relief, participants were frequently underwhelmed by the results and described having expected more from exome sequencing. All participants reported discussing the results with at least some family, friends, and healthcare providers. Participants’ recollection of the results returned to them was sometimes incorrect or incomplete, in many cases aligning with their perceptions of their health risks when entering the study. These results underscore the need for different genetic counseling approaches for generally healthy patients undergoing exome sequencing, in particular the need to provide anticipatory guidance to moderate participants’ expectations. They also provide a preview of potential challenges clinicians may face as genomic sequencing continues to scale‐up in the general population despite a lack of full understanding of its impact.
Retracted: Design, Synthesis and Molecular Modeling of Nonsteroidal Anti‐inflammatory Drugs Tagged Substituted 1,2,3‐Triazole Derivatives and Evaluation of Their Biological Activities
Authors: Dasari Srinivasa Rao , Tondepu Subbaiah , Vadali Lakshmana Rao , Seelam Nareshvarma 
Published: March 2019

A novel series of 1,4‐disubstituted‐1,2,3‐triazole derivatives 3a–l and 5a–i were one‐pot synthesized via CuAAC‐alkyne click chemistry and evaluated for their antibacterial activity against four organisms and screened for their anticancer activity against human colon cancer cell line HT‐29 and human lung cancer cell line HTB‐29. These hybrid molecules structure elucidation has been performed by IR, 1H‐NMR, 13C‐NMR, and mass spectral analysis. Synthesized nonsteroidal anti‐inflammatory drugs‐triazoles evaluated for their antibacterial activities against bacterial microorganisms Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Klebsiella pneumonia. Final compounds 3i, 3c, and 5b showed magnificent broad spectrum activity against P. aeruginosa, K. pneumonia, E. coli, and S. aureus with zone of inhibition values of 20, 15, 17, and 16 mm, respectively. Among the series of compound, 3j showed the best antibacterial activity against all the strains. Further, the compounds 3i and 5a were more cytotoxic than cisplatin against all tested two human cancer cell lines, with 50.8%, and 52.3% and 73.4% and 75.3% of growth, respectively. The synthesized compounds were tested for kinase inhibitory activity against glycogen synthase kinase‐3 protein kinases, in addition, for cytotoxic activity against two different human cancer cell lines.
Pegunigalsidase alfa, a novel PEGylated enzyme replacement therapy for Fabry disease, provides sustained plasma concentrations and favorable pharmacodynamics: A 1‐year Phase 1/2 clinical trial
Authors: Schiffmann Raphael , Goker‐Alpan Ozlem , Holida Myrl , Giraldo Pilar , Barisoni Laura , Colvin Robert B. , Jennette Charles J. , Maegawa Gustavo , Boyadjiev Simeon A. , Gonzalez Derlis , Nicholls Kathy , Tuffaha Ahmad , Atta Mohamed G. , Rup Bonita , Charney Martha R. , Paz Alona , Szlaifer Mali , Alon Sari , Brill‐Almon Einat , Chertkoff Raul , Hughes Derralynn 
Published: March 2019

AbstractPegunigalsidase alfa, a novel PEGylated, covalently crosslinked form of α‐galactosidase A developed as enzyme replacement therapy (ERT) for Fabry disease (FD), was designed to increase plasma half‐life and reduce immunogenicity, thereby enhancing efficacy compared with available products. Symptomatic adults with FD participated in this open‐label, 3‐month dose‐ranging study, followed by a 9‐month extension. Three cohorts were enrolled in a stepwise manner, each receiving increased doses of pegunigalsidase alfa: 0.2, 1.0, 2.0 mg/kg, via intravenous infusion every other week. Pharmacokinetic analysis occurred on Day 1 and Months 3, 6, and 12. Kidney biopsies at baseline and Month 6 assessed peritubular capillary globotriaosylceramide (Gb3) content. Renal function, cardiac parameters, and other clinical endpoints were assessed throughout. Treatment‐emergent adverse events (AEs) and presence of immunoglobulin G (IgG) antidrug antibodies (ADAs) were assessed. Sixteen patients completed 1 year's treatment. Mean terminal plasma half‐life (each cohort) ranged from 53 to 121 hours. All 11 male and 1 of 7 female patients presented with classic FD phenotype, in whom renal peritubular capillary Gb3 inclusions were reduced by 84%. Mean estimated glomerular filtration rate was 111 mL/min/1.73 m2 at baseline, remaining stable throughout treatment. Three patients developed treatment‐induced IgG ADAs; following 1 year's treatment, all became ADA‐negative. Nearly all treatment‐emergent AEs were mild or moderate. One patient withdrew from the study following a serious related AE. Pegunigalsidase alfa may represent an advance in ERT for FD, based on its unique pharmacokinetics and apparent low immunogenicity.
Retrospective evaluation of exposure indicators: a pilot study of exposure technique in digital radiography
Authors: Lewis Shantel , Pieterse Tracey , Lawrence Heather 
Published: March 2019

AbstractIntroductionDigital radiography lacks visual clues of exposure techniques used to obtain radiographs, therefore manufacturers have included exposure indicators (EIs). EIs provides feedback about exposure techniques used and evaluating EIs will yield much needed information about exposure trends used in digital radiography.MethodsA retrospective explorative quantitative study was conducted at nine randomly selected imaging departments in Gauteng, South Africa. Data pertaining to EI was retrospectively collected using quota sampling and compared to manufacturer recommended (MR) standards.ResultsA total of 1422 EIs were collected. 50% of these were within the MR standard. 27% of EI indicated overexposure and 23% indicated underexposure.ConclusionsGreater evidence of overexposure was noted in the retrospective analysis of the EI. This pilot study shows the need for further investigation into exposure technique practices in digital radiography and the need for measures to halt the evidenced overexposure.
Gait signals classification and comparison
Authors: Barua Arnab , Yang Xiaodong , Ren Aifeng , Fan Dou , Guan Lei , Zhao Nan , Haider Daniyal 
Published: March 2019

AbstractUse of wireless signal technology in sensing of human gait activity is a satisfactory example of device‐free sensing and effective in medical science to detect human motion–related diseases. Some prior research showed some potential detecting process of human walking gait from wireless channel information (WCI) using wireless signals. In this paper, we present comparison of three popular features reduction methods such as principal component analysis (PCA), kernel principal component analysis (KPCA), and linear discriminant analysis (LDA) using three classifications methods, support vector machine (SVM), k‐nearest neighbor (k‐NN), and decision tree (DT) in an absolutely equivalent situation for identifying walking gait signals. The analysis was carried out on the WCI‐based dataset where dataset was divided into four classes (normal gait, small gait, fast gait, and turn gait). Using dataset with the combination of methods (features reduction and classification), experimental results shows that all the combinations of PCA, KPCA, and LDA with three classifications achieve an average accuracy of gait identification is accordingly 86%, 79%, and 95%.