bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Pemberian Minuman Sopi Mayang Beralkohol terhadap Jumlah Spermatozoid, Pada Tikus Putih (Rattus norvegicus) Jantan
Authors: Sanaky Marliyati , Idris Irfan , Rafiah Siti , Arsyad Aryadi 
Published: October 2024

ABSTRACT The alcoholic Sopi drink comes from palm trees (Arenga pinnata MERR), a type of palm tree spread throughout almost all of Indonesia. The alcohol in the traditional Sopi drink is ethanol (CH3CH2-OH) from fermented sap. This study aimed to examine the effect of Sopi Mayang drink on the increase in cytochrome P450 mRNA expression, increase in CYP2E1 protein levels and decrease in the number of spermatozoids using male white rats. This research is laboratory experimental, using the Randomized Post-test Only Control Group Design. Giving Sopi Mayang with a dose of 2.7 ml decreased the number of spermatozoids, namely 33,815,000, compared to the control group without giving Sopi Mayang, namely 56,680,000 (p = 0.0001). Sopi Mayang, with a dose of 4.05 ml, decreased sperm count from 33,815,000 to 22,334,775 (p= 0.0001). Sopi Mayang, with a dose of 5.4 ml, decreased sperm count from 22,865,000 to 18,250,309 (p=0.0001). There was a decrease in the number of spermatozoids in mice given Sopi Mayang. Keywords: Alcohol, Sopi Mayang, Spermatozoid, white rats ABSTRAK Minuman Sopi beralkohol berasal dari pohon Enau/Aren (Arenga pinnata MERR) termasuk salah satu jenis tanaman palma, yang tersebar hampir di seluruh wilayah Indonesia. Alkohol yang terkandung dalam minuman tradisional Sopi adalah etanol (CH2CH3-OH) dari fermentasi nira. Penelitian ini ditujukan untuk melihat pengaruh minuman Sopi Mayang terhadap jumlah peningkatan ekspresi mRNA sitokrom P450, peningkatan kadar protein CYP2E1dan penurunan jumlah spermatozoid dengan menggunakan tikus putih jantan. Penelitian ini adalah eksperimental laboratoris, dengan menggunakan rancangan The Randomized Post-test Only Control Group Design. Pemberian Sopi Mayang dengan dosis 2,7 ml terjadi penurunan jumlah spermatozoid yaitu 33.815.000 dibandingkan dengan kelompok kontrol tanpa pemberian Sopi Mayang yaitu 56.680.000 (p = 0,0001). Sopi Mayang dengan dosis 4,05 ml terjadi penurunan jumlah sperma dari 33.815.000 menjadi 22.334.775 (p= 0,0001). Sopi Mayang dengan dosis 5,4 ml terjadi penurunan jumlah sperma dari 22.865.000 menjadi 18.250.309 (p=0,0001). Terjadi penurunan jumlah spermatozoid, pada tikus yang diberikan Sopi Mayang. Kata Kunci: Alkohol, Sopi Mayang, Spermatozoid, Tikus Putih
Analisis Faktor yang Berhubungan dengan Hipotermi Pasca General Anestesi di Instalasi Bedah Sentral
Authors: Hadariah Hadariah , Najihah Najihah , Ose Maria Imaculata , Wijayanti Dewi , Pujianto Ahmat 
Published: October 2024

ABSTRACT More than 80% of operations use general anesthesia techniques. and it was found that 2.5% of patients experienced complications after undergoing anesthesia. Nearly 30% of post-anesthesia patients experience hypothermia. The negative impacts of hypothermia on patients include increased risk of bleeding, myocardial ischemia, longer recovery after anesthesia, impaired wound healing, and increased risk of infection. The aim of this study was to analyze factors associated with hypothermia after general anesthesia at IBS RSUD dr. H. Jusuf SK Tarakan. This research is a quantitative research with 60 respondents. Respondents in this study were post-general anesthesia patients using consecutive sampling technique. The statistical test used is the Chi-Square test. The results of the study showed that factors associated with hypothermia after general anesthesia were age, BMI, gender, type of operation and duration of operation in a central surgical installation. So it can be concluded that there is a relationship between the factors age, BMI, gender, length of operation and type of operation with hypothermia after general anesthesia at IBS RSUD dr. H. Jusuf SK. Therefore, it is hoped that the hospital can create an SOP regarding the management of preventing hypothermia in post-surgical patients. Keywords: Factor, Hypothermia, General Anesthesia ABSTRAK Lebih dari 80% operasi menggunakan teknik general anastesi. dan ditemukan 2,5% pasien mengalami komplikasi setelah menjalani anestesi. Pasien pasca anestesi hampir 30% mengalami kejadian hipotermi. Dampak negatif hipotermi terhadap pasien, antara lain risiko perdarahan meningkat, iskemia miokardium, pemulihan pasca anestesi yang lebih lama, gangguan penyembuhan luka, serta meningkatnya risiko infeksi. Tujuan penelitian ini untuk menganalisis faktor yang berhubungan dengan hipotermi pasca general anestesi di IBS RSUD dr. H. Jusuf SK Tarakan. Penelitian ini merupakan penelitian kuantitatif dengan 60 responden. Responden dalam penelitian ini merupakan pesien pasca general anestesi dengan teknik pengambilan sample consecutive sampling. Uji statistik yang digunakan adalah uji Chi-Square. Hasil penelitian menunjukkan bahwa faktor yang berhubungan dengan hipotermi pasca general anestesi adalah usia, IMT, jenis kelamin, jenis operasi dan lama operasi di instalasi bedah sentral. Sehingga dapat disimpulkan bahwa terdapat hubungan antara faktor usia, IMT, jenis kelamin, lama operasi dan jenis operasi dengan hipotermi pasca general anestesi di IBS RSUD dr. H. Jusuf SK. Oleh karena itu, diharapkan pihak rumah sakit dapat membuat SOP terkait manajemen pencegahan hipotermi pada pasien pasca bedah Kata Kunci: Faktor, Hipotermi, General Anastesi
Intensitas Penggunaan Gadget pada Siswa SMP Swasta di Lubuk Pakam
Authors: Sitanggang Lipan Yohana Beatry , Nasution Siti Saidah , Daulay Wardiyah 
Published: October 2024

ABSTRACT Intensity of gadget use is the level of gadget use in humans which is thought to be influenced by several characteristics, namely characteristics related to self Alone and the environment. This research was conducted on junior high school children. Intensity of gadget use among junior high school children in Lubuk Pakam school students This research method use is descriptive. The research results show the of the 48 respondents who used gadgets the highest was in the medium category as much as 89.6% (43 respondents). After conducting research, the results showed that the intensity of gadget use in teenagers (junior high school) was highest in the moderate category, so it was suggested that parents need to monitor the duration of gadget use in children to prevent addiction and reduce other negative impacts. Keywords: Intensity Of Gadget Use, Adolescent ABSTRAK Intensitas penggunaan gadget merupakan tingkat penggunaan gadget pada manusia yang diduga dipengaruhi oleh beberapa karakteristik yaitu karakteristik yang berkaitan dengan diri sendiri dan lingkungan. Penelitian ini dilakukan pada anak SMP. Intensitas penggunaan gadget pada siswa SMP di sekolah Lubuk Pakam. Penggunaan metode penelitian ini bersifat deskriptif. Hasil penelitian menunjukkan dari 48 responden yang menggunakan gadget paling tinggi berada pada kategori sedang sebanyak 89,6% (43 responden). Setelah dilakukan penelitian, diperoleh hasil bahwa intensitas penggunaan gadget pada remaja (SMP) paling tinggi berada pada kategori sedang, sehingga disarankan agar orang tua perlu memantau durasi penggunaan gadget pada anak untuk mencegah kecanduan dan mengurangi dampak negatif lainnya. Kata Kunci: Intensitas Penggunaan Gadget, Remaja
Hubungan Tingkat Stress dengan Pola Tidur pada Anak Usia Sekolah Kelas 4 dan 5 yang Akan Melaksanakan Ujian Akhir Semester di MI Al Ikhlas Depok
Authors: Bringgandini Lusy , Risdiana Rani 
Published: October 2024

ABSTRACT Stress is the body's response to situations that cause emotional tension, pressure, changes, and others. Stress can also be caused by individual factors, psychological factors, and there are several types of psychological stressors such as frustration, conflict, and pressure. Students who are about to face final semester exams will certainly experience stress that affects their sleep patterns. To determine the relationship between stress levels and sleep patterns in 4th and 5th grade school children who will be taking final semester exams at MI Al-Ikhlas Depok. This study is a quasi-analytic type with a cross-sectional research design involving total sampling of 60 respondents from MI Al-Ikhlas Depok. Data were collected using questionnaires. Data analysis was conducted using univariate and bivariate analysis with chi-square test using SPSS software. The research found a p-value of 0.042, indicating a significant relationship between stress levels and sleep patterns in 4th and 5th grade school children who will be taking final semester exams. There is a significant relationship between stress levels and sleep patterns in 4th and 5th grade school children who will be taking final semester exams at MI Al-Ikhlas Depok. Students can create a well-regulated study and rest schedule to reduce stress and improve sleep quality when facing final semester exams. Keywords: Sleep Patterns, Academic Stress, Stress Levels ABSTRAK Stress merupakan respon tubuh terhadap situasi yang menimbulkan ketegangan emosi, tekanan, perubahan dan lain-lain. Stress juga dapat disebabkan oleh faktor individu, psikologis, serta ada beberapa jenis stressor psikologis yaitu frustasi, konflik dan tekanan. Siswa yang akan menghadapi ujian semester akhir tentunya akan mengalami stress yang berpengaruh terhadap pola tidur. Tujuan dari penelitian ini untuk mengetahui hubungan tingkat stress dengan pola tidur pada anak usia sekolah kelas 4 dan 5 yang akan melaksanakan ujian akhir semester di MI Al-Ikhlas Depok”. Jenis penelitian ini adalah quasi analitik dengan desain penelitian cross sectional dengan total sampling pada 60 responden MI Al-Ikhlas Depok, data diambil melalui kuesioner. Analisa data dilakukan dengan analisis univariat dan analisis bivariat menggunakan uji chi-square program SPSS. Hasil penelitian didapatkan nilai p-value sebesar 0,042 hal ini menunjukan bahwa adanya hubungan yang signifikan antara tingkat stress dengan pola tidur pada anak usia sekolah kelas 4 dan 5 yang akan melaksanakan ujian akhir semester. Kesimpulan dari penelitian ini yaitu adanya hubungan antara tingkat stress dengan pola tidur pada anak usia sekolah kelas 4 dan 5 yang akan melaksanakan ujian akhir semester di MI Al-Ikhlas Depok. Siswa/siswi dapat membuat jadwal belajar dan istirahat yang teratur dengan baik untuk mengurangi stres dan meningkatkan kualitas tidur pada saat akan melaksanakan ujian akhir semester. Kata Kunci: Pola Tidur, Stress Akademik, Tingkat Stress
The effects of assessment instruction and test anxiety on divergent components of creative problem-solving tasks
Authors: Prokofieva Victoria , Fenouillet Fabien , Romero Margarida 
Published: October 2024

IntroductionThis study looked at how an assessment instruction and test anxiety (TA) can influence divergent thinking (DT) components of creativity in a playful robotic problem-solving task.MethodsWe measured TA and creative performance (TD) under assessment and non-assessment conditions in 122 secondary students engaged in creative problem solving (CPS).ResultThe aspects of DT (fluidity and originality) showed a tendency to be impacted by assessment instruction. Thus, under non-assessment conditions, the learners show higher fluidity and better originality in the first occurrence of the CPS task. In the second occurrence, time spent on CPS decreases. Moreover, the originality turns to be impaired in the second trial and only student under assessment maintain their engagement in the activity. No correlation was found between TA and DT, and no gender or age differences were observed. The results suggest that TA does not influence the performance of the students involved in creative problem-solving processes.DiscussionWe discuss the findings in relation to game-based learning specificities. The assessment instruction in playful activities can be perceived as a positive challenge and even the students showing higher levels of test anxiety do not perceive it as a threat. Furthermore, if time constraints are minimized, the impact of assessment instruction on creative performance might be further reduced. The finding of this study opens promising perspectives to the research on innovative forms of school assessment and creative problem solving.
Direct Preparation of Alginate Oligosaccharides from Brown Algae by an Algae-Decomposing Alginate Lyase AlyP18 from the Marine Bacterium Pseudoalteromonas agarivorans A3
Authors: Sun Xiao-Hui , Zhang Xiao-Dong , Zhang Xin-Ru , Wang Xiao-Fei , Zhang Xi-Ying , Zhang Yu-Zhong , Zhang Yu-Qiang , Xu Fei 
Published: October 2024

Alginate oligosaccharides (AOs), derived from alginate degradation, exhibit diverse biological activities and hold significant promise in various fields. The enzymatic preparation of AOs relies on alginate lyases, which offers distinct advantages. In contrast to the conventional use of sodium alginate derived from brown algae as the substrate for the enzymatic preparation of AOs, AO preparation directly from brown algae is more appealing due to its time and energy efficiency. Thus, the identification of potent alginate lyases and cost-effective brown algae substrates is crucial for optimizing AO production. Herein, we identified and characterized an alginate lyase, AlyP18, capable of efficiently decomposing algae, from a marine bacterium Pseudoalteromonas agarivorans A3 based on secretome analysis. AlyP18 is a mesothermal, endo-type and bifunctional alginate lyase with high enzymatic activity. Two brown algae substrates, Laminaria japonica roots and Macrocystis pyrifera, were used for the AO preparation by AlyP18. Upon optimization of AlyP18 hydrolysis parameters, the substrate degradation efficiency and AO production reached 53% and ~32% for L. japonica roots, respectively, and 77% and ~46.5% for M. pyrifera. The generated AOs primarily consisted of dimers to pentamers, with trimers and tetramers being dominant. This study provides an efficient alginate lyase and alternative brown algal feedstock for the bioconversion of high-value AOs from brown algae.
Innovative Solutions for Sustainable Logistics in Food Manufacturing Industries overcome Barriers and Challenges
Authors: Anisha A , Chandrasekar K 
Published: October 2024

This paper explores innovative solutions for sustainable logistics in the food manufacturing industry, focusing on how these strategies address key challenges. It examines how advancements in technology, logistics strategies, and eco-friendly practices contribute to sustainability while maintaining efficiency and profitability. The study analyzes data from companies that have adopted modern logistics solutions, such as AI-driven optimization, renewable energy, and circular supply chain models, supplemented by expert interviews to gain practical insights. The findings reveal that these solutions help reduce carbon emissions, minimize food waste, and optimize resource use. Companies that have implemented these strategies have successfully overcome common barriers such as high costs, infrastructure complexity, and regulatory challenges. While the research focuses on large-scale manufacturers, smaller companies remain under explored, suggesting the need for future studies on scalability and policy frameworks to support wider adoption. This paper offers a unique contribution by combining current innovations in sustainable logistics with practical industry challenges, providing actionable insights for food manufacturers and laying the foundation for further research into overcoming financial and technological barriers.
OBJECTIVIZATION OF SURGICAL TACTICS IN CASE OF COVERING TISSUE GUNSHOT DEFECTS RESTORATION
Authors: І.А. Lurin , І.P. Khomenko , M.A. Kashtalyan , V.V. Nehoduiko , R.S. Vastyanov , S.V. Tertyshnyi , G.F. Stepanov , O.I. Solodyanikova , N.V. Tanasichuk-Gazhieva 
Published: October 2024

The article presents the results of the objectification of surgical tactics in the restoration of defects in the integumentary tissue due to gunshot wounds in 126 soldiers. For this purpose, all the wounded were divided into 2 groups: Group I included 68 wounded, in whom 75 reconstructive operations were performed under dynamic angiographic multimodal control. Group II consisted of 58 wounded patients who underwent 96 surgical operations using conventional tactics. Rapid restoration of damaged anatomical structures and their aesthetic appearance, reduction of scars showed good results of operations in group I of patients. The results of the work show that dynamic monitoring improves the quality of surgical reconstructive operations and can be recommended at all stages of medical care.
В статье представлены результаты объективизации хирургической тактики восстановления дефектов покровной ткани вследствие огнестрельных ранений у 126 военнослужащих. Для этого все раненые были разделены на 2 группы: в I группу вошли 68 раненых, у которых под динамическим ангиографическим мультимодальным контролем было выполнено 75 реконструктивных операций. II группу составили 58 раненых, которым выполнено 96 хирургических операций с использованием общепринятой тактики. Быстрое восстановление поврежденных анатомических структур и ихesthetic изгляда, уменьшение рубцов показали хорошие результаты операций у больных I группы. Результаты работы показывают, что динамический мониторинг повышает качество хирургических реконструктивных операций и может быть рекомендован на всех этапах оказания медицинской помощи.
Məqalədə odlu silahla yaralanmış 126 döyüşçüdə örtük toxuma defektlərinin bərpasında cərrahi taktikanın obyektivləşməsinin nəticələri təqdim edilib. Bu məqsədlə yaralılar 2 qrupa bölünüblər: I qrupa 68 yaralı daxil edilib; dinamik angioqrafik multimodal nəzarət altında 75 rekonstruktiv-bərpaedici əməliyyat yerinə yetirilib; II qrupa daxil edilmiş 58 yaralıda isə adi taktika ilə 96 cərrahi əməliyyat aparılıb. Zədələnmiş anatomik strukturların tez bərpası və onların estetik görünüşü, çapıqların kiçilməsi I qrupdakı xəstələrdə əməliyyatın nəticələrinin yaxşı olduğunu göstərib. Aparılan işin nəticələri göstərir ki, dinamik monitorinq cərrahi rekonstruktiv-bərpa əməliyyatlarının keyfiyyətini yaxşılaşdırır və tibbi yardımın bütün mərhələlərində tətbiq edilə bilər.
Penyuluhan Hormon Paratiroid, Kalsitonin, dan Obat yang Bekerja pada Tulang di SMAN 1 Karawang
Authors: Mulki Munir Alinu , Putra Rizki Rava Dwi , Saputri Jasmine Rahma , Marisa Siti Rosilfa , Alfiandri Ihsan 
Published: October 2024

Kalsium merupakan mineral yang paling penting bagi berbagai fungsi di dalam tubuh. Kelenjar paratiroid dan tiroid bertanggung jawab mengatur kadar kalsium dalam tubuh dengan cermat. Penyusunan jurnal ini ditujukan untuk mengamati pengetahuan siswa SMAN 1 Karawang terkait pengetahuan tentang hormon paratiroid, kalsitonin beserta obat yang bekerja pada tulang, karena berdasarkan survei yang telah dilakukan diketahui bahwa siswa-siswa SMAN 1 Karawang kurang memahami mengenai pengetahuan hormon paratiroid, kalsitonin beserta obatx yang bekerja pada tulang. Metode yang diterapkan adalah metode tes untuk menguji kemampuan responden berupa pemberian Pre-Test dan Post-Test, data tes tersebut diolah menggunakan aplikasi SPSS. Hasil Post-Test menggambarkan bahwa terdapat kenaikan nilai sebanyak 18,4% setelah dilakukan kegiatan penyampaian materi. Hal ini dapat diketahui dari nilai hasil rata-rata Pre-test 5,58 dan setelah dilakukan penyuluhan terdapat peningkatan nilai rata-rata Post-test menjadi 7,42. Dengan demikian, dapat disimpulkan bahwa penyuluhan kesehatan memiliki dampak signifikan terhadap pengetahuan siswa-siswi di SMAN 1 Karawang mengenai hormon paratiroid, kalsitonin beserta obat yang bekerja pada tulang.
Gebyar Safari KB “Pemasangan dan Pencabutan Alat Kontrasepsi Implan dan IUD di Puskesmas Rengasdengklok Kabupaten Karawang”
Authors: Setiawati Riska , Wariah Uway , Yanti Irma 
Published: October 2024

Program KB yang dilaksanakan dengan baik dapat mencegah angka kelahiran yang tinggi. Penggunaan kontrasepsi jangka panjang seperti IUD dan Implan sangat efektif digunakan untuk mencegah kehamilan, akan tetapi penggunaannya masih sanagat rendah. Tujuan pengabdian masyarakat ini diharapkan dapat meningkatkan pengetahuan dan minat Pasangan Usia Subur (PUS) dalam mengambil keputusan dan menentukan pilihan dalam pengunaan alat kontrasepsi khususnya metode jangka panjang yaitu IUD dan Implat. Metode yang digunakan adalah penyuluhan kepada WUS dan PUS yang berdomisili di wilayah Kecamatan Rengasdengklok tentang IUD dan implant, yang selanjutnya dilakukan safari KB bagi peserta penyuluhan yang memutuskan menggunakan alat kontrasepsi IUD atau implant. Hasil dari kegiatan pengabdian masyarakat ini adalah WUS dapat mengetahui macam-macam alat kontrasepsi serta dapat menambah pengetahuan tentang ketepatan penggunaan alat kontrasepsi sesuai kondisi kesehatanya. Dari hasil penyuluhan, WUS yang bersedia dan hadir pada saat kegiatan pemasangan dan pencabutan alat kontrasepsi IUD dan implant adalah 34 orang dengan 6 orang memilih IUD dan 28 orang memilih implan.
Costs of Potential Medication Wastage Due to Switching Treatment Among People With Multiple Sclerosis
Authors: Okuda Darin T. , Patel Achal , Schuldt Robert , Abioye Ibraheem , Bonine Nicole G. 
Published: October 2024

Background: Unused medications negatively impact healthcare resource utilization and environmental safety, contribute substantially to annual healthcare expenditures, and may ultimately affect patient health outcomes. People with multiple sclerosis (PwMS) commonly switch disease-modifying therapies (DMTs), leading to medication wastage and substantial costs for insurers and patients. Objectives: To estimate the cost associated with potential medication wastage (PMW) in a subcohort of PwMS receiving oral or self-injectable US Food and Drug Administration–approved DMTs who switched DMTs in a calendar year in the United States. Methods: This retrospective cohort study included adults with MS and used PharMetrics® Plus claims data from 2017 to 2021. PwMS were required to have 12 months of continuous eligibility for the entire year and a claim for at least 2 unique DMTs during the same calendar year. The PMW cohort was defined as those who had an aggregate overlap in days’ supply across DMT switches within the year; those in the non-PMW cohort did not. The cost of PMW for insurers and PwMS due to overlap was calculated only at the point of switch to the new DMT and defined as the cost of the remaining days’ supply of the prior DMT. Results: The number of PwMS meeting the inclusion criteria was 1762 in 2017, 1947 in 2018, 1679 in 2019, 1461 in 2020, and 1782 in 2021. Approximately 95% of PwMS switched DMTs once within single calendar years, and 25% (n = 381-464) contributed to PMW. For those who had overlapping DMT supply, it was estimated that 34% to 38% of the DMT being switched from was potentially wasted. The total cost of PMW paid by the insurer and PwMS ranged from $1 200 866 to $1 489 859. While most of the total cost ($1 172 140-$1 450 328) was paid by the insurer, PwMS still owed substantial amounts ($28 726-$74 578). Across all PwMS, the per person per year cost ranged from $716 to $846. The estimated wastage and associated costs were consistent across all study years. Conclusions: DMT switching is common among PwMS, resulting in PMW and high costs to patients and insurers.