bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement
Authors: Bennett Jonathan , Thornton George D. , Nitsche Christian , Gama Francisco F. , Aziminia Nikoo , Gul Uzma , Shetye Abhishek , Kellman Peter , Davies Rhodri H. , Moon James C. , Treibel Thomas A. , Adams Benjamin , Ambekar Shirish , Aktuerk Dincer , Awad Wael , Baumbach Andreas , Bhattacharyya Sanjeev , Di Salvo Carmelo , Kolvekar Shyamsunder , Lall Kulvinder , Lawrence David , Lopez-Marco Miss Ana , Lloyd Guy , Kennon Simon , Manisty Charlotte , Mathur Anthony , Mravljak Rok , Mullen Michael , Oo Aung , Ozkor Mick , Pierce Iain , Roberts Neil , Sheikh Amir , Shipolini Alex , Uppal Rakesh , Wong Phooi Kit , Yates Martin , Yap John 
Published: December 2024

BACKGROUND:
In aortic stenosis, the myocardium responds with left ventricular hypertrophy, which is characterized by increased left ventricular mass due to cellular hypertrophy and extracellular matrix expansion. Following aortic valve replacement (AVR), left ventricular hypertrophy regression occurs, but early cellular and extracellular dynamics are unknown.

METHODS:
Patients with severe symptomatic aortic stenosis undergoing surgical or transcatheter AVR were prospectively recruited. Pre- and early post-AVR cardiac magnetic resonance imaging assessed left ventricular remodeling, global longitudinal strain, and T1 mapping to determine extracellular volume fraction and volume of cellular and extracellular compartments.

RESULTS:

In all, 39 patients (aged 71.4±9.8 years, male 79%, aortic valve peak velocity 4.4±0.5 m/s) underwent cardiac magnetic resonance before and at median 7.7 weeks post-AVR. Left ventricular mass index reduced significantly by 15.4% (
P
<0.001*), primarily driven by cellular compartment regression (18.7%,
P
<0.001*), with a smaller reduction in the extracellular compartment (7.2%,
P
<0.001*). This unbalanced regression led to an apparent increase in extracellular volume fraction (27.4±3.1% to 30.2±2.8%;
P
<0.001*). Although there was no significant change in global longitudinal strain post-AVR, an increase in extracellular volume fraction was associated with worsening of global longitudinal strain (Pearson r=0.41,
P
=0.01). Mode of intervention (transcatheter versus surgical) did not influence the above myocardial parameters post-AVR (all
P
>0.05). The asterisk in
P
values indicates a statistical significance of <0.05.

CONCLUSIONS:
Within 8 weeks of AVR for aortic stenosis, substantial left ventricular hypertrophy regression occurs involving both cellular and extracellular compartments, demonstrating the early myocardial adaptability to afterload relief. Cellular compartment regression is greater than extracellular regression, leading to an apparent increase in extracellular volume fraction. Mode of intervention did not affect degree of reverse remodeling, indicating that both are effective at resulting beneficial changes post-AVR.

REGISTRATION:

URL:
https://www.isrctn.com
; Unique identifier: NCT04627987.
Picking Up a Friend along the Way: A′-Movement through the v/VP Region in Avatime
Authors: Major Travis , Torrence Harold 
Published: December 2024

Abstract
This paper investigates the nature of successive cyclicity. Based on novel data from Avatime, this paper provides further evidence that successive cyclic A′-movement obligatorily transits through the vP region of all clauses between the extraction site and the landing site of the wh-expression. Evidence comes from pied-piping patterns related to wh-movement and pieces of complex verbal idioms.
The Uncanny: New Directions
Authors: Ataria Yochai 
Published: December 2024

Abstract
This paper delves into the concept of the uncanny, a theme that has fascinated scholars across multiple disciplines, including psychology, philosophy, literature, and film studies. The study’s primary goal is twofold: to examine the theoretical foundations of the uncanny as explored by Jentsch, Freud, and Heidegger, and to propose a new perspective on the uncanny within the context of modern technological and urban developments. The paper argues that urban, technologically advanced environments foster conditions in which the uncanny can easily emerge, and suggests that the adoption of a techno-scientific worldview plays a central role in the rise of uncanny experiences. Through an analysis of Hoffmann’s The Sandman, this paper revisits classical theories of the uncanny and connects them with contemporary realities. Jentsch’s emphasis on cognitive uncertainty, Freud’s exploration of repressed traumatic memories, and Heidegger’s focus on the broader atmospheric conditions of the uncanny are all examined. The paper concludes by reflecting on how urbanization, technological dependency, and scientific reductionism contribute to a profound sense of alienation, increasing the likelihood of uncanny experiences in the modern world.
Searching for the identity of Podisus Herrich-Schäffer, 1851 (Hemiptera: Pentatomidae): examination of type specimens leads to taxonomic updates and description of five new species
Authors: Brugnera Ricardo , Sampaio Vinícius , Campos Luiz Alexandre , Grazia Jocelia 
Published: December 2024

Abstract
The Asopinae are a group of stink bugs (Pentatomidae) distinctive by having predatory feeding habits, preying on other insects, especially larvae of butterflies, moths, and beetles. Many species are common, and due to their alimentary strategies, some are objects for application in biological control programs. Podisus Herrich-Schäffer is the most diverse genus of Asopinae, distributed in the Neotropical and Nearctic regions, and their species have received attention in applied studies since the second half of the 20th century. However, the systematics of Podisus is still overlooked, and the lack of robust taxonomic information and poor species delimitation lead to misidentifications. We searched for the type specimens of Podisus deposited in the NHMUK, NHRS, MNHN, and RBINS collections in order to validate the taxonomic status of the species, and to proceed with the necessary taxonomic updates. We propose four new synonymies: Podisus volxemi Distant new junior synonym of Podisus crassimargo (Stål); Ornithosoma rivierei Kormilev and monotypic genus Ornithosoma Kormilev as new junior synonyms of Podisus semialbus Walker and genus Podisus respectively. Podisus dufouri Bergroth and Podisus punctiger Stål are revalidated, and Podisus cornutus (Dallas) is treated as species inquirenda. Five new species are described and fully illustrated: Podisus amboroensis Brugnera, sp. nov., Podisus awajun Brugnera, sp. nov., Podisus bororo Brugnera Grazia, sp. nov., Podisus guarani Brugnera & Grazia, sp. nov., and Podisus quechua Brugnera & Sampaio, sp. nov.. We highlight the importance of the examination of type material, historical specimens, and descriptions in the taxonomy of Podisus, and suggest caution in the identification of species due to the expressive number of incongruences found in previous studies.
Imagining Closure as a Proprioceptive Problem
Authors: Rossmanith Kate 
Published: December 2024

Abstract
This essay aims to advance theorisations of ‘closure’ as an emotion concept, and to offer new understandings of the relationship between emotion and imagination, including how such a dynamic might be studied. In justice contexts, ‘closure’ operates clumsily as both a legal outcome and an emotional expectation, an imagined affective state. Drawing on ethnographic fieldwork and interviews with people who work in, and who are caught up in, the justice system, the essay deploys approaches from phenomenological anthropology and creative writing to show how people’s imagining of ‘closure’ is often experienced proprioceptively, not narratively. It also shows the entanglement of form and method: how the essay form can be deployed in research as a critical imaginative tool.
From Migration Legends to Regional Identity: the Formation of the Ming-Qing State
Authors: Zhao Shiyu , Lu Jenny 
Published: December 2024

Abstract
Recent years have seen extensive discussions on identity issues across various disciplines. Within the field of history, particularly significant are the debates concerning the “New Qing History” in American Sinology and the special issue on James Watson in the American journal Modern China. These discussions are closely tied to the emphasis on diversity and the exploration of the grand unification mechanism in Chinese studies, both domestically and internationally. Migration legends offer a critical lens for examining regional identity, encapsulating the dynamic shifts in regional identities and the historical processes of state formation during the Ming and Qing dynasties, from the 16th to the 18th centuries. Such discussions of identity and state formation should be contextualized within specific historical and spatio-temporal frameworks.
Model-Based Study of Near-Surface Transport in and around Cape Cod Bay, Its Seasonal Variability, and Response to Wind
Authors: Gregory Margaret , Rypina Irina I. , Yoshida Sachiko , Macdonald Alison M. 
Published: December 2024

Abstract
Output from a high-resolution numerical model is used to study near-surface transport in and around Cape Cod Bay using a Lagrangian approach. Key questions include the following: What are the dominant transport pathways? How do they vary in time on seasonal-to-interannual scales? What is the role of wind in driving this variability? Application to a possible release of wastewater into Cape Cod Bay from the recently closed Pilgrim Nuclear Power Station is discussed. Analysis reveals a seasonality in Cape Cod Bay transport patterns, with shorter residence times throughout the bay and an increased probability of outflow waters exiting the bay during spring and summer. Wind-induced Ekman currents are identified as a dominant driver of this variability.

Significance Statement
This study is motivated by a possible release of radioisotope-contaminated wastewater into Cape Cod Bay, a region important to fishing, aquaculture, and tourist industries. The specific aim is to better understand near-surface transport patterns and mechanisms in Cape Cod Bay both in general and within the context of a wastewater release from Pilgrim Nuclear Power Station.
Research progress on influencing factors and intervention measures of pre-hospital delays in acute ischemic stroke
Authors: Shi Liming , Xu Muqun , Su Qingjie 
Published: December 2024

Background Stroke, a leading cause of health impairment globally, sees intravenous thrombolysis as the primary treatment during the acute phase, yet delays persist due to pre-hospital and in-hospital factors. While research has reduced in-hospital delays significantly, pre-hospital delays remain a concern both domestically and internationally. Objective This article aims to provide a comprehensive review of the research progress on the influencing factors and intervention measures of pre-hospital delays in acute ischemic stroke. Methods By analyzing the literature, summarize the risk factors leading to treatment delay in acute ischemic stroke (AIS), and provide a review of potential improvement methods. Results Pre-hospital delay in acute ischemic stroke (AIS) is influenced by both objective factors like age, gender, and regional economic status, as well as subjective factors such as stroke awareness. The introduction of “Stroke 120,” a stroke education slogan tailored to Chinese language habits, aims to improve stroke awareness and address delayed treatment and low AIS venous thrombolysis utilization among the Chinese public Conclusion In conclusion, collaborative efforts from the government, society, and hospitals are essential to enhance stroke education comprehensively. This will ensure widespread awareness of stroke knowledge, facilitating timely and effective treatment for AIS patients.
Elevated IL-10 serum levels are associated with slower serological response following syphilis treatment during pregnancy
Authors: Kiolbasa Martyna , Kotlarz Agnieszka , Kaminiów Konrad , Pastuszczak Maciej 
Published: December 2024

Background Approximately 50% of pregnant individuals treated for syphilis do not achieve a decline in non-treponemal titers by delivery. The serological response in pregnant persons is significantly slower compared to non-pregnant individuals, with unclear pathogenesis and clinical significance. This study aimed to determine the association between the host immune response and serological outcome in pregnant individuals with syphilis. Methods Twenty-four females with early syphilis, including 14 pregnant individuals, were included. Pro-inflammatory and regulatory cytokines (IFN-γ, TNF-α, IL-4, IL-1β, IL-10, TGF-β) were measured before treatment and 6 months after penicillin injection. Results The median time to serological cure was 5 months for pregnant individuals and 2 months for non-pregnant females. Pregnant individuals had significantly higher serum levels of IL-10 and TGF-β at baseline and at 6 months post-treatment compared to non-pregnant individuals ( p < .05). Conclusions A robust regulatory immune response to syphilis may be associated with a slower serological response to therapy during pregnancy.
Identification of IFITM3 as a diagnostic biomarker of systemic lupus erythematosus and its association with disease activity based on multi-omics and experimental verification
Authors: Li Yan , Zhang Jimin , Liu Xiaomei , Zhang Xinwei , Shi Guixiu 
Published: December 2024

Background Systemic lupus erythematosus is a clinically heterogeneous autoimmune disease that lacks reliable diagnostic biomarkers. In our study, we aimed to identify a novel biomarker for the diagnosis and disease activity monitoring of SLE. Methods Bulk RNA and scRNA-seq datasets were obtained from the Gene Expression Omnibus database. In this study, differential analysis, cell-cell communication algorithm, functional enrichment analysis, human protein map database analysis, protein-protein interaction analysis and immune cell infiltration analysis were utilized to identify the hub genes between SLE and healthy groups. Furthermore, clinical data from 68 SLE patients and 31 healthy controls were collected for verification. Changes in IFITM3 levels were confirmed through quantitative real-time polymerase chain reaction, western blotting, and flow cytometry analyses. Result Bioinformatic analyses showed that IFITM3 expression was significantly upregulated in peripheral monocytes from patients with SLE. IFITM3 mRNA levels showed a significant diagnostic value for SLE, with an AUC value of 87.14%. IFITM3 expression was associated with the systemic lupus erythematosus disease activity index, as well as C3, C4, and IgG levels. The results of Chi-square test showed that those in the IFITM3-positive group had a higher percentage of several clinical manifestations such as thrombocytopenia, leukopenia, low complement, and fever. Conclusions These findings indicated an obviously increased expression of IFITM3 in peripheral blood monocytes of patients with SLE and verified IFITM3 as a promising diagnostic marker for SLE and associated with disease activity.
The effectiveness of microfracture augmentation on the wall of femoral condyle in meniscal healing among patients with meniscus tears after sports injury
Authors: Sakti Muhammad , Singjie Leonard Christianto , Horas Notinas , Nelwan Dario Agustino 
Published: December 2024

Background Meniscus injuries are familiar sources of knee pain, with meniscus repair sometimes yielding unsatisfactory results. Microfracture is a standard procedure for treating articular cartilage damage in the knee that promotes the formation of fibrocartilage over damaged cartilage. Microfracture enhanced the healing rate of meniscus repair in animal models. Objective Investigate the effectiveness of microfracture augmentation on the wall of femoral condyle in meniscus healing among patients with meniscus repair. Methods The current study, conducted in a single center, involved patients with red-white zone meniscal tears due to sports injury who underwent arthroscopic meniscus repair between January 2018 and December 2023. Meniscal repair was performed without microfracture in the control group but with microfracture augmentation in the intervention group. Results Functional outcomes, assessed using the Lysholm score, were significantly better in the microfracture group ( p = 0.000). Both groups showed significant reductions in tear size according to its intensity on magnetic resonance imaging (MRI) ( p = 0.002 in the control group and p = 0.001 in the microfracture group), with a notably better meniscus healing rate (35.7%) in the microfracture group compared to the control group. Conclusion This initial study highlights substantial effectiveness between meniscus repair augmented with microfracture and enhanced healing compared to repair without microfracture. Functional scores were notably higher, and MRI signal intensity decreased to grade 1 in a significant portion of patients in the microfracture group.
Evaluating the Implementation and Impact of BRAF Reflex Mutation Testing in Melanoma, Lung, and Colorectal Cancers
Authors: Guerra Ordaz Daniel Josué , Whitelaw Sera , Kaouache Mohammed , Moustaqim-Barrette Amina , Gresham Louise , Ramchatesingh Brandon , Redpath Margaret , Chergui May , Litvinov Ivan V. 
Published: December 2024

Background: Reflex molecular testing, the process of profiling specimens at diagnosis, is emerging in oncology, allowing for prompt therapy initiation, and potentially improving outcomes. This study evaluates the impact of reflex BRAF testing on treatment timelines and outcomes in melanoma, lung and colorectal cancers at the McGill University Health Center (MUHC). Methods: A retrospective chart review was conducted at the MUHC. The study included patients with melanoma, lung, and colorectal cancers who underwent BRAF testing from 2017 to 2022. Data on demographics, cancer type, stage, test ordering specialist, testing method, and treatment outcomes were extracted. Statistical analyses included descriptive and multivariate regression analyses. Results: 518 BRAF molecular tests were performed, with 173 patients meeting the inclusion criteria [median age 72 (IQR 60-80 years), 46.2% female]. Of these, 75.7% had melanoma, 23.7% colorectal cancer and 0.58% lung cancer. Pathologists ordered 71.1% of BRAF tests, primarily relying on immunohistochemistry. By 2022, all BRAF results were available before oncology consultations. Patients with pre-consultation BRAF results were more likely to receive targeted therapy (59.4% vs 36.4%). The availability of BRAF test results was associated with quicker treatment initiation and better alignment of therapy with mutation status. Conclusion: This study underscores the success of the pathology team at MUHC in implementing reflex BRAF mutation testing, enhancing clinical care by ensuring the timely availability of test results. Delays in testing may adversely affect clinical decision-making and therapy selection, highlighting the need for standardized reflex testing protocols across Canada to optimize patient outcomes in melanoma, lung, and colorectal cancers.
World Stroke Organization (WSO): Global intracerebral hemorrhage factsheet 2025
Authors: Parry-Jones Adrian R , Krishnamurthi Rita , Ziai Wendy C , Shoamanesh Ashkan , Wu Simiao , Martins Sheila O , Anderson Craig S 
Published: December 2024

Background: Intracerebral hemorrhage (ICH) is stroke caused by non-traumatic bleeding into the brain. Aim: This factsheet provides summary statistics for ICH from the 2021 Global of Burden of Diseases Study. Methods: Data were downloaded from the GBD results platform using “intracerebral hemorrhage” as a Level 4 cause of death or injury, extracting key metrics (number, percent, rate) for measures (incidence, disabilty adjusted life years [DALYs], deaths) described in this factsheet. Results: Globally, stroke was the third leading cause of death in 2021, and ICH accounted for 28.8% of incident strokes. There were estimated to be 7,252,678 deaths due to stroke in 2021 of which ICH accounted for 3,308,367 (45.6%). When considering the burden of ICH in terms of DALYs, ICH accounts for nearly half of the burden of stroke at 49.5%, compared to 43.8% caused by ischemic stroke. ICH must therefore be considered on an equal footing with ischemic stroke, so that efforts can be made to reduce its burden through public health, research, and healthcare provision. Although the overall age-standardized incidence of ICH has been decreasing since 1990, the rate of reduction has been much slower in regions with lower socio-demographic index (SDI). Most of the burden of ICH lies in areas with lower SDI, with 94.2% of DALYs lost to ICH outside areas of high SDI. Geographically, the majority of DALYs due to ICH occur in Southeast Asia, East Asia, and Oceania, with 53.3% of global DALYs lost in these regions alone. The risk factors for ICH are dominated by high systolic blood pressure, which accounts for at least 50% of the burden of ICH, regardless of SDI. Areas with middle or high-middle SDI have a greater proportion of the burden of ICH accounted for by ambient particulate pollution, smoking, and diets high in sodium, whereas household air pollution from solid fuels accounts for much more of the risk of ICH in low SDI regions. Conclusion: This World Stroke Organization (WSO) Global ICH Fact Sheet 2025 provides the most updated information on ICH that can be used to support communication with all internal and external stakeholders, inform healthcare policy, and raise public awareness. All statistics have been reviewed and approved for use by the WSO Executive Committee.
New strategies for enhancing enrollment of underrepresented minorities in lymphoma clinical trials
Authors: Nze Chijioke , Herrera Alex F. 
Published: December 2024

Abstract
New lymphoma treatments, including chimeric antigen receptor T cells, bispecific antibodies, and immune checkpoint inhibitors, have significantly improved patient outcomes. Despite these therapeutic advances, only 2% to 3% of adult patients with cancer participate in clinical trials. This participation is even lower among certain groups, including ethnic and racial minorities, individuals with low socioeconomic status, rural residents, older adults, and young adults. Underrepresentation of these groups in clinical trials limits the generalizability of trial results and is detrimental to those populations that do not receive equal access to novel therapies. Although racial and ethnic minorities constitute &gt;40% of the US population, they make up only ∼15% of clinical trial participants. The US Food and Drug Administration now requires sponsors seeking regulatory approval for therapies via registrational clinical trials to submit a plan to ensure diversity among trial participants. This article addresses strategies for enhancing enrollment of underrepresented minorities in lymphoma clinical trials.