bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Са2+,Мg2+-ATPase of blood lymphocytes in women with ovarian cancer
Authors: Barylyak R. V. , Iefremova U. P. , Onufrovych O. K. , Melnyk O. V. , Vorobets D. Z. , Vorobets Z. D. 
Published: April 2018

Ionized Ca2+ is crucial for regulation of practically all intracellular processes, including tumor growth, cell proliferation, apoptosis, etc. The plasma membrane Ca2+,Mg2+-ATPase plays an important role in maintaining intracellular Ca2+ homeostasis. The function of this enzyme is to reduce the Ca2+ concentration in the cytosol, namely its transport against a concentration gradient in the extracellular medium. We have investigated the activity of plasma membrane Ca2+,Mg2+-ATPase of lymphocytes of practically (clinically) healthy women of different age groups and also patients with ovarian cancer stage III and IV. It was found that the enzyme activity in women of the older age group was not significantly reduced in relation to the activity of the younger age group. Thus, the value of the maximum rate of ATP hydrolysis by plasma membrane Ca2+,Mg2+-ATPase of blood lymphocytes in practically healthy women under the conditions of physiological norm was 1.1 times higher than under of pre-nosological state. In patients with ovarian cancer (stages III and IV), plasma membrane Ca2+,Mg2+-ATPase activity of blood lymphocytes significantly differed from the physiological norm and decreased by 1.6 and 1.8 times, compared with the physiological norm. The decrease of the plasma membrane Ca2+,Mg2+-ATPase activity of blood lymphocytes in patients with ovarian cancer indicates an increase of Ca2+ in the cytosol of lymphocytes. Determination of affinity constants showed that these values were in the submillimolar range of concentration, corresponding to the physiological concentration in the cell cytoplasm (0.5–5.0 mM). In healthy persons, under the condition of physiological norm, the affinity constant of plasma membrane Сa2+,Mg2+-ATPase to the ATP was 0.16 ± 0.02 mM and at pre-nosological state – 0.19 ± 0.02 mM. The affinity constant of plasma membrane Сa2+,Mg2+-ATPase of lymphocytes to ATP in patients with ovarian cancer (stage ІІІ) was 0.32 ± 0.03 mM and with ovarian cancer (stage IV) 0.35 ± 0.03 mM. That is, the affinity constant of plasma membrane Ca2+,Mg2+-ATPase of lymphocytes to ATP in patients with ovarian cancer was 2.0–2.1 times higher than this value for the blood lymphocytes in the control group (physiological norm). The kinetic analysis of Ca2+-activated, Mg2+-dependent hydrolysis of ATP in blood lymphocytes in women showed that the decrease in the activity of Ca2+,Mg2+-ATPase was due to a decrease in the affinity of the enzyme to the substrate (KATP increases 2-fold).
Serum paraoxonase activity in patients with rheumatoid arthritis, its relationship with the clinical course and cardiovascular compications
Authors: Shevchuk S. V. , Seheda Y. S. , Galyutina O. Y. , Masik N. P. , Shevchuk O. V. 
Published: April 2018

Nowadays low paraoxonase activity is generally recognized as an independent risk factor of cardiovascular diseases involved in pathologic remodeling of the heart and vessels as well as thrombosis in the general population. But the role of paraoxonase activity in RA patients is unknown. Based on the above, the aim of the work was to study serum paraoxonase activity in patients with rheumatoid arthritis, to evaluate its association with clinical course and structural and functional status of the cardiovascular system. 67 patients with RA, 18 males and 49 females were studied. The control group consisted of 25 apparently healthy individuals. Rheumatoid arthritis was diagnosed according to international classification criteria ACR 2012. The indices of total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and triglycerides (TG) in blood serum were determined by standard conventional methods. Low density lipoprotein cholesterol (LDLC) values were calculated by Friedwald formula. Serum paraoxonase activity was measured by spectrophotometric method. High resolution ultrasound and Doppler ultrasonography of the brachial artery were performed to study endothelium function. Sonographic B-mode scanning and pulsed Doppler ultrasound of heart and blood flow spectra were done on ultrasound scanner. Serum paraoxonase activity was found to be about 18.8% lower in the patients with RA than in the control group. Serum paraoxonase activity was shown to decrease proportionally to the increase of the age in RA patients. In the group of patients over 45, the level of the enzyme was 13.0% lower than in the patients over 30. The study established that the increase of systolic and diastolic arterial pressure is associated with decrease of serum paraoxonase activity in RA patients. The patients with RA combined with arterial hypertension had significantly (by 10.9%) lower activity of the studied enzyme than those with no arterial hypertension. However, no significant relationship between paraoxonase activity and duration of the disease, obesity and smoking was revealed. Paraoxonase activity in RA patients was demonstrated to be dependent on lipid levels. The lowest paraoxonase activity was recorded in individuals with the highest levels of TC, LDLC and the lowest HDLC indices. Paraoxonase activity in RA patients is associated not only with atherosclerotic vascular damage (IMT, decreased FMDBA) but also with structural and functional heart status (systolic and diastolic functions, left ventricular myocardial hypertrophy). Decreased serum paraoxonase level is suggested to be the predictor of early development of cardiovascular complications in RA patients.
The impact of certain flavourings and preservatives on the survivability of larvae of nematodes of Ruminantia
Authors: Boyko O. O. , Brygadyrenko V. V. 
Published: April 2018

Annualy, helminthic diseases are one of the causes of economic losses in agriculture. Ruminantia are most often observed to be infected with nematodes of the gastrointestinal tract, including Strongyloides papillosus and the representatives of the Strongylida order. Identifying factors which could cause a decrease in the level of infection of agricultural animals with helminthiases would allow stock-raising facilities to regularly achieve high quality dairy and meat production in sufficient quantity. On the basis of this study, we determined the impact of flavourings and source materials approved for use in and on foods (isoamyl alcohol, isoamyl acetate, raspberry ketone, trilon B, methylparaben) on the survivability of larvae of Strongyloides papillosus and Haemonchus contortus, parasitic nematodes of Ruminantia animals. Among these substances, the lowest efficiency against the nematode larvae was found in isoamyl alcohol, isoamyl acetate and trilon B. A stronger effect was caused by methylparaben (for L3 S. papillosus LD50 = 0.67 ± 0.04%, L1 and L2 S. papillosus – LD50 = 0.0038 ± 0.0008%, L3 H. contortus – LD50 = 0.89 ± 0.15%). Minimum efficient dosage of the solutions was 10 g/l. Significant antihelminthic properties were manifested by raspberry ketone (for L3 S. papillosus LD50 = 1.00 ± 0.72%, L1 and L2 S. papillosus – LD50 = 0.07 ± 0.06%, L3 H. contortus – LD50 = 0.39 ± 0.26%). The results show that there is considerable potential for further studies on the antiparasitic properties of these substances against nematodes in the conditions of farming enterprises and agricultural complexes.
Лісівничо-таксаційна оцінка лісів Горган
Authors: Lavnyy V. , Dychkevych V. 
Published: April 2018

Проаналізовано картографічний матеріал підприємств та встановлено межі регіону досліджень. Проаналізовано розподіл лісових насаджень досліджуваної території за типами лісу, запасом, часткою і продуктивністю ялинових лісів, класами бонітету, групами віку, відносними повнотами і категоріями лісових земель.
Площа лісів регіону досліджень становить 262242,3 га. Серед типів лісу переважає волога буково-ялицева сусмеречина, яка займає 27,9% лісової території Горган. На другому місці за площею серед типів лісу знаходиться волога буково-смерекова суяличина, частка якої становить 13,4%. Частка вологої смереково-ялицева субучини становить 10,4% та вологої чистої сусмеречини – 10,3%.
Найбільший середній запас деревостанів спостережено у Карпатському НПП – 372 м3/га, а найменший – у ДП "Солотвинське ЛГ" (228 м3/га). У Горганах переважають високобонітетні насадження першого і вищих класів бонітету. Найбільше їх є в Українському НДІ гірського лісівництва (91,9%), Карпатському НПП (77,1%) та ДП "Делятинське ЛГ" (72,7%), а найменше – у ПЗ "Горгани" (26,0 %) і ДП "Мокрянське ЛМГ" (30,2%).
На території Горган переважають середньовікові деревостани, які займають 32,7% ділянок, вкритих лісовою рослинністю. Серед відносних повнот насаджень у регіоні досліджень переважають середньо- і високоповнотні деревостани, які займають відповідно 44,5% і 40,5% лісів. Низькоповнотні насадження становлять 13,9%, а рідколісся – 1,0%.
У Горганах 51,3% лісової площі становлять ліси природного походження, частка лісових культур становить 38%, незімкнутих лісових культур – 2,4% і зрубів – 2,1%.
Oligo- és poliszacharidok, proteoglikánok
Authors: Jakab Lajos 
Published: April 2018

Abstract: After clearing up the confusion in the previously used nomenclature, the paper discusses the family of small-leucin-rich glycoproteins. After mentioning the family and its role in the organisation of the ground substance and in the regulation of inflammation, one unique molecule of proteoglycans is presented. This molecule is the inter-α-trypsin inhibitor. It has turned out that this peculiar molecule originally contains glycosaminoglycan beside the neutral carbohydrates. After summarizing the numerous connections of the proteoglycan molecule, the “self-sacrificing” nature of the molecule is presented. It is noted that the functions of the ovaries are also controlled by this molecule. The unique structure and fundamental function of the CD44 is also analysed. The CD44 is a transmembrane proteoglycan receptor with diverse functions and actions. The organisation has intramolecular, transmembrane sections, a stalk and one globular part and contains glycosaminoglycan and oligosacharids, too. The construction contains sialic acid residues at end positions of the molecular chains, which hinder it from joining other sialic acid structures in terminal positions. Therefore, this molecule has to be separated to open up a way for the sequencing neutral molecule (e.g., hyaluronan) to be attached. CD44 is the most important, but not the only receptor of hyaluronan. It can form connections with a lot of constructions, e.g., blood cells, the human endothelial, adventitial and mesenchymal. Human extracellular matrix proteinases can change the receptor’s structures. Both the molecular and the supramolecular complexes boast unique features. The giant hyaluronan chains can connect to hyaluronan-binding proteoglycans – particularly hyaladherins to hyaluronectins – to create supramolecular connections and networks. The molecular mass of the fragments of hyaluronan is in the range of some kDs, while the whole molecule weighs up to several million Ds. The fragments are independent masses and can form attachments by themselves. The fragments have important inflammatory effects. Previously unidentified proteoglycan fragments have also been identified. Five of the ten identified fragments are secreted after synthetizing and stored in the granula of human cells. These strange characteristics are connected to the features of chromogranins/secretogranins. Nevertheless, this is another system of the organism, the functional, molecular structures of which are synthetized in neuroendocrine cells. Orv Hetil. 2018; 159(16): 620–627.
Metasztatikus progresszió kezelése primer cutan és ocularis melanoma szinkrón előfordulását követően
Authors: Imrédi Eleonóra , Plótár Vanda , Szavcsur Péter , Pánczél Gitta , Melegh Krisztina , Schlachter Krisztina , Liszkay Gabriella 
Published: April 2018

Abstract: The incidence rates of cutaneous melanoma in non-Hispanic whites show an increasing tendency with age. While uveal melanoma in general is a rare disease, representing only 4% of all melanomas with an incidence rate of 0.6 per 100 000, it is still the most frequent malignancy of the eye. Synchronous occurrence of ocular and cutaneous melanoma is an exceptional rarity, due to the distinct genetic background of the diseases. We report the case of a 80-year-old man who underwent total excision of a cutaneous melanoma in 2008. In 2013, he was diagnosed with uveal melanoma as part of a routine work-up for reduced vision. The uveal melanoma was treated by brachytherapy. In 2015, liver metastases were suspected by routine ultrasonography. Core biopsy was carried out, and the histology confirmed melanoma metastases. The molecular analysis of the cutaneous lesion showed gain of function mutation of the BRAF V600 K gene, while we found a wild-type BRAF gene in the metastatic lesion. Based on the recommendation of the oncoteam, hepatic intra-arterial Epirubicin-Platidiam therapy was introduced. He received 11 doses of intra-arterial chemotherapy (IAC), in 21 cycles. IAC was well tolerated without any catheter-related complications or toxicities. Partial regression of the hepatic metastases were documented in February 2016. After completing the eleventh cycle of intrahepatic chemotherapy, the disease remained in complete remission for over a year. The parallel occurrence of cutaneous and ocular melanoma is rare, however, the metastatic progression in such cases make the selection of optimal medical therapy challenging. The distinct genetic background of two melanoma types may help the identification of the source of the metastatic lesions, in order to guide the treatment decisions. Orv Hetil. 2018; 159(16): 642–647.
Raynaud-szindrómás betegek életminőségének jellemzői
Authors: Fábián Balázs , Csiki Zoltán , Bugán Antal 
Published: April 2018

Abstract: Introduction: Raynaud’s disease is characterized by episodic vasospastic attacks and digital ischemia usually followed by pain, numbness and cold. Despite the severity of the symptoms, the investigation of the quality of life in this disease received less attention yet. Aim: The aim of the study was to examine how the disease affects the patients’ quality of life. Method: Semi-structured interviews were made with 28 patients diagnosed with Raynaud’s disease. Results: Almost every domain of quality of life is negatively affected. The somatic symptoms cause significant suffering, they are accompanied by loss of functionality; frequent preventive actions are needed; furthermore they affect job performance, commuting and sleep quality. Emotional and cognitive burdens and negative changes in interpersonal relationships were found. Conclusion: The findings of this study show that the disease is present as significant hardship in every aspect of daily life. Because of the decrease in the quality of life and the psychological burdens caused by this chronic disease, not only the basic medical care, but psychological treatment is also indicated. Orv Hetil. 2018; 159(16): 636–641.
Antihyperglykaemiás kezelés hatékonyságát megítélő randomizált, kontrollált klinikai tanulmányok obszervációs jellegű utánkövetései. II. Az utánkövetés sajátosságai és diabetológiai tanulságai
Authors: Jermendy György 
Published: April 2018

Abstract: Although the outcomes of the follow-up investigation period of the randomized clinical studies for evaluating the efficacy of a treatment or an antidiabetic drug may be confounded or potentially biased by several factors, the results are widely accepted by the diabetes community. In line with the theory of metabolic memory or metabolic legacy, early and intensive antihyperglycaemic treatment should be provided for all diabetic patients as this strategy can result in beneficial effects even in the long run. The recent cardiovascular safety trials with new, innovative antidiabetic drugs differ in several aspects from the former efficacy studies. Ten cardiovascular safety trials were completed so far enabling to define their unique and common features. It can be anticipated that the era of randomized, controlled efficacy studies with observational follow-up investigations came to an end in diabetes research. Nowadays, cardiovascular safety trials are in the focus of clinical research in diabetology and results of several ongoing studies are expected with interest in the near future. Orv Hetil. 2018; 159(16): 615–619.
A III. szintű neonatális intenzív centrumokban dolgozó orvosok szakmai és családi jellemzői, nehézségei, elégedettsége, erőforrásai. Magyarországi helyzetkép
Authors: Soósné Kiss Zsuzsanna , Feith Helga Judit , Szabó Miklós , Gradvohl Edina 
Published: April 2018

Abstract: Introduction: A survey that investigates the situation of physicians working at neonatal intensive care (NIC) centres has not been made since 1997. Aim: To give an overview of the sociodemographic characteristics; personal and professional problems; the satisfaction with their job and family roles; their levels of healthy lifestyle; resources in the families of physicians working at NIC. Method: We have made an examination in Hungary at NIC among physicians from April 2015 till January 2016, with an anonym self-fill-in questionnaire. Results: The physicians involved in the research (n = 111) are representatively middle-aged people. They are well-qualified and hold a subordinate post. Most of them have second jobs. The manager and deputy-manager positions are characteristic for the men. Most of them live in family. The main problems for them are financial and professional difficulties, not the family or personal problems. They have conflicts in families because of finding partners and having children as well as job problems. They are satisfied with their parenting, partnership and professional roles but they are not contented with their family role as a financial safety provider person and as a person living a healthy life. In difficult situations in their life, they can count on friends and family members, furthermore they can rely on their workmates and superiors. Conclusion: It is the first research that focuses on the general situation of physicians working at level 3 NIC centres. This is the first time when a survey investigates their professional-personal-family life. Orv Hetil. 2018; 159(16): 628–635.
O papa e as questões da família: às voltas com gênero e orientação sexual
Authors: Lima Luís Corrêa 
Published: April 2018

As transformações na família nas últimas décadas, com a emergência de novas configurações, são um desafio para a Igreja Católica e sua missão de evangelizar. A mensagem cristã no campo sexual e familiar tem um valor inegável, mas também problemas e questionamentos inevitáveis. Em alguns pontos, há uma notável disparidade entre a doutrina e a vida da maioria dos fiéis. Em 2013, o papa Francisco convocou o Sínodo dos Bispos voltado para o tema da família, lançando na Igreja um amplo debate sobre estes temas, como nunca se viu nas últimas décadas. Um resultado deste processo foi a publicação do documento normativo pelo papa em 2016, a Exortação Pós-sinodal Amoris Laetitia sobre o amor na família. Questões de gênero, orientação sexual e união homossexual tem sido foco de conflitos entre religiosos e outros segmentos da sociedade, incidindo no Estado e nas políticas públicas. Entretanto, muitas ideias surgidas no contexto do Sínodo, bem como alguns conteúdos da Exortação, podem contribuir consideravelmente para abrir novos caminhos.
The relationship between psychopathology, psychosocial adjustment, social support and quality of life in multiple sclerosis
Authors: KOTAN Vahap Ozan , KOTAN Zeynep , AYDIN Birgül , TAŞKAPILIOĞLU Özlem , ALKAN Berna , ÖZKAYA Güven , SARANDÖL Aslı , TURAN Ömer Faruk , Kırlı Selçuk 
Published: April 2018

Objectives: Multiple
Sclerosis (MS) is a chronic disease which affects physical,psychological and
social functioning of patients. In this study we aim to indicate psychiatric
comorbidity, some psychosocial factors and their associations with quality of
life in patients with MS. Methods: A total of 227 patients
underwent psychiatric examination and the following scales were applied:
Socio-demographic data form, Hospital Anxiety and Depression Scale (HADS),
Multiple Sclerosis Quality of Life-54 (MSQOL-54), Psychosocial Adjustment to
Illness Scale-Self report (PAIS-SR) and Multidimensional Scale of Perceived
Social Support (MSPSS). Results: Among 227 patients with MS,
67.8% (n = 154) had psychiatric diagnosis; 24.2% (n = 55) had depression,19.8%
(n = 45) had adjustment disorder, 14.9% (n = 34) had anxiety disorder, 7.1%
(n=16) had dysthymic disorder and 1.8% (n = 4) had bipolar disorder. Patients
with a psychiatric diagnosis had lower scores in role limitations due to
emotional problems, emotional well-being, health perceptions, social function,
cognitive function, health distress and mental health composite of MSQOL-54.
PAIS-SR and MSPSS scores were significantly lower in MS patients with a
psychiatric diagnosis. PAIS-SR scores were negatively
correlated with role limitations-emotional, emotional well-being, social
function, sexual function, satisfaction with sexual function, physical health
composite and mental health composite scores of MSQOL-54. MSPSS total score was
positively correlated with emotional well-being score of MSQOL-54. Conclusions: In MS patients, there is a high prevalence of psychopathology and it is
associated with quality of life, perceived social support and psychosocial
adjustment of the patients. Quality of life is reduced especially in emotional
and mental aspects in patients with a psychiatric diagnosis. Diagnosis and
treatment of psychopathology in MS patients seems crucial to decrease disease
burden.
How to Survive in a Declining Industry? A study of the clothing industry in Southern Italy
Authors: Carbonara Nunzia 
Published: April 2018

<p>The aim of this paper is to identify possible competitive strategies that guarantee the survival of a declining industry. To reach this aim an explorative empirical research based on a multiple case study design has been developed. The research focuses on the textile and clothing industry and studies seven target companies operating in different textile and clothing subsectors. Empirical results allow to define a strategic business framework consisting of three competitive strategies each one characterized by a strategic goal and implemented by three macro-strategic actions: deindustrialization, internationalization, and leverage networking.</p>
The Influence Factors and International Comparison of Currency Crises under Abnormal Flow of Capital
Authors: He Yan 
Published: April 2018

<p class="16" align="justify"><span>The paper</span><span> </span><span>focused on improving</span><span> </span><span>the measurement methods about the scale of international capital flow and </span><span>put</span><span>ting</span><span> forward the </span><span>C</span><em><span>omprehensive </span></em><em><span>M</span></em><em><span>easuring </span></em><em><span>M</span></em><em><span>ethod</span></em><span> </span><span>by which to</span><span> </span><span>analyze</span><span> </span><span>and compare the </span><span>abnormal flow</span><span>s</span><span> of international capital of 11 countries in which currency crises occurred</span><span> by</span><span> the empirical test</span><span>s. In addition, t</span><span>he </span><span>author</span><span> </span><span>studied the influence factors and ways of abnormal flow of capital from three aspects, and tried to provide scientific early-warning tool and countermeasures for preventing currency crises.</span></p>