bluuebunny/crossref_metadata_2025_split huggingface dataset:
Swedish Design
Authors: Brunnström Lasse 
Published: April 2019

Swedish Design: A History provides a fascinating and comprehensive introduction to the development of design in Sweden from the mid-nineteenth century to the early twenty-first.
Leading design historian Lasse Brunnström traces the move from artisanal crafts production to the mass production and consumption of designed objects, a process by which the role and profile of the designer became increasingly important. His survey, richly illustrated with images of the designed objects discussed, takes in forms of design traditionally associated with Sweden, such as household objects and textiles, while also considering some less-written about genres such as industrial and graphic design. Brunnström questions many established ideas about design in Sweden, notably its aesthetics and its relationship to Sweden's national and political culture. He argues that the history of design in Sweden has been far more complex and less straightforwardly ‘blond’ than hitherto understood.
Changing Things
Authors: Redström Johan , Wiltse Heather 
Published: April 2019

Many of the things we now live with do not take a purely physical form. Objects such as smart phones, laptops and wearable fitness trackers are different from our things of the past. These new digital forms are networked, dynamic and contextually configured. They can be changeable and unpredictable, even inscrutable when it comes to understanding what they actually do and whom they really serve.
In this compelling new volume, Johan Redström and Heather Wiltse address critical questions that have assumed a fresh urgency in the context of these rapidly-developing forms. Drawing on critical traditions from a range of disciplines that have been used to understand the nature of things, they develop a new vocabulary and a theoretical approach that allows us to account for and address the multi-faceted, dynamic, constantly evolving forms and functions of contemporary things. In doing so, the book prototypes a new design discourse around everyday things, and describes them as fluid assemblages.
Redström and Wiltse explore how a new theoretical framework could enable a richer understanding of things as fluid and networked, with a case study of the evolution of music players culminating in an in-depth discussion of Spotify. Other contemporary ‘things’ touched on in their analysis include smart phones and watches, as well as digital platforms and applications such as Google, Facebook and Twitter.
Soviet Critical Design
Authors: Cubbin Tom 
Published: April 2019

Soviet Critical Design is the first monograph to explore the socialist design practice of ‘artistic projecteering’, which was developed by the USSR’s Senezh Experimental Studio in the 1960s.
Tom Cubbin first examines the studio as a site for the development of the design discipline in the optimistic environment of the Soviet Thaw of the 1960s. He then explores how designers adapted to new realities of the Soviet Union of the 1970s and 80s. Over two decades, designers at the studio worked on critical projects that highlighted how the Soviet state’s treatment of citizens, urban heritage and the environment was manifest in daily life.
Drawing on previously unpublished visual material from private archives and also extensive interviews, this book presents a new history of the late socialist period in the USSR, which gives insight into the creative strategies of designers who engaged their practice as a contribution to broader discussions on alternative models for socialist existence. Overall, it argues that artistic projecteering must be read as a utopian activity which privileged the political and ideological over the functional.
The Power and Influence of Illustration
Authors: Male Alan 
Published: April 2019

Delving into the rationale behind influential communication, The Power and Influence of Illustration helps you understand how to work with a message to create convincing illustrations for your audience.
Alan Male explains how illustrative imagery can lampoon, shock, insult, threaten, subvert, ridicule, express discontent and proclaim political and religious allegiance. He explores how its tools have been used in the past, and looks at how contemporary illustrators can use their own work to persuade – and discusses where the line between persuasion and propaganda lies. These issues are explored using hundreds of full colour images from international artists, both contemporary and historical.
Writing For the Design Mind
Authors: Ilyin Natalia 
Published: April 2019

“Becoming a designer takes a huge amount of time and education. With so many skills to learn, many people never get the chance to master the one skill that can give them a real advantage in business or academia: They never learn to write well.”
In Writing for the Design Mind author, designer and educator Natalia Ilyin offers clear, concise, and humorous writing tips, techniques and strategies to people who have spent their lives mastering design rather than learning to write.
Ilyin's book helps designers approach writing in the same ways they approach designing – teaching skills and methods through encouragement, practical exercises and visual advice.
Writing well is a skill, like any other, and with this book you can learn to do it with confidence.
Designing for Society
Authors: Tromp Nynke , Hekkert Paul 
Published: April 2019

Our globalized world is encountering problems on an unprecedented scale. Many of the issues we face as societies extend beyond the borders of our nations. Phenomena such as terrorism, climate change, immigration, cybercrime and poverty can no longer be understood without considering the complex socio-technical systems that support our way of living. It is widely acknowledged that to contend with any of the pressing issues of our time, we have to substantially adapt our lifestyles. To adequately counteract the problems of our time, we need interventions that help us actually adopt the behaviours that lead us toward a more sustainable and ethically just future.
In Designing for Society, Paul Hekkert and Nynke Tromp provide a hands-on tool for design professionals and students who wish to use design to counteract social issues. Viewing the artefact as a unique means of facilitating behavioural change to realise social impact, this book goes beyond the current trend of applying design thinking to enhancing public services, and beyond the idea of the designer as a facilitator of localized social change.
Modern Asian Design
Authors: Huppatz D. J. 
Published: April 2019

Modern Asian Design provides a comprehensive introduction to the development of Asian design in the modern period, both tracing historical threads and offering a theoretical framework within which to chart the history of design in Asia.
Rather than a singular “Asian history”, this book presents a series of studies centred on trade routes, colonial relationships, regional networks and cross-cultural exchanges. Modern Asian Design builds on existing resources beyond design history in an effort to map the field, focusing particularly on relations between Asia and the West and also across Asian design cultures.
Opening with a brief overview of trade and exchange networks in the 17th and 18th centuries, the bulk of this study comprises analysis of the development of modern design in Asia during the later 19th and early 20th centuries, a period of rapid modernisation. The book’s final two chapters bring these central ideas into a contemporary and highly relevant context.
Reproductive biology of Hybopsis amblops, the Bigeye Chub, in the Flint River of Alabama
Authors: Tarver Crissy L , Stallsmith Bruce W 
Published: April 2019

Background. The purpose of this study was to establish a reproductive schedule and examine reproductive traits that shape fecundity of the Bigeye Chub, Hybopsis amblops Cyprinidae, in the Flint River system of north Alabama.
Methods. Life history traits associated with reproduction, growth, and maturation were assessed. Fish collections were made monthly from August, 2013, through July, 2014.
Results. The Bigeye Chub in Alabama primarily spawns in April and May as indicated by gonadosomatic index (GSI), ovarian condition and clutch size. Average GSI values began to rise in February, peaked in April and May at over 13% for females and 1.6% for males, and showed a steep decline from May to June for both sexes. Average clutch size was highest in April at 812. Diameter of the most mature oocyte stage averaged 0.74 mm, relatively small compared to other cyprinids found in the Flint River.
Discussion. The Bigeye Chub’s relatively large clutch size as a measure of fecundity places the species intermediate between opportunistic and periodic in the trilateral life history scheme of Winemiller and Rose. The species is apparently responding to a flow regime with a defined seasonality as well as predictability of flow and resources.
Artificial Synapses Based on Multiterminal Memtransistors for Neuromorphic Application
Authors: Wang Lin , Liao Wugang , Wong Swee Liang , Yu Zhi Gen , Li Sifan , Lim Yee‐Fun , Feng Xuewei , Tan Wee Chong , Huang Xin , Chen Li , Liu Liang , Chen Jingsheng , Gong Xiao , Zhu Chunxiang , Liu Xinke , Zhang Yong‐Wei , Chi Dongzhi , Ang Kah‐Wee 
Published: April 2019

AbstractNeuromorphic computing, which emulates the biological neural systems could overcome the high‐power consumption issue of conventional von‐Neumann computing. State‐of‐the‐art artificial synapses made of two‐terminal memristors, however, show variability in filament formation and limited capacity due to their inherent single presynaptic input design. Here, a memtransistor‐based artiﬁcial synapse is realized by integrating a memristor and selector transistor into a multiterminal device using monolayer polycrys‐talline‐MoS2 grown by a scalable chemical vapor deposition (CVD) process. Notably, the memtransistor offers both drain‐ and gate‐tunable nonvolatile memory functions, which efficiently emulates the long‐term potentiation/depression, spike‐amplitude, and spike‐timing‐dependent plasticity of biological synapses. Moreover, the gate tunability function that is not achievable in two‐terminal memristors, enables significant bipolar resistive states switching up to four orders‐of‐magnitude and high cycling endurance. First‐principles calculations reveal a new resistive switching mechanism driven by the diffusion of double sulfur vacancy perpendicular to the MoS2 grain boundary, leading to a conducting switching path without the need for a filament forming process. The seamless integration of multiterminal memtransistors may offer another degree‐of‐freedom to tune the synaptic plasticity by a third gate terminal for enabling complex neuromorphic learning.
High‐Performance Hierarchical Black‐Phosphorous‐Based Soft Electrochemical Actuators in Bioinspired Applications
Authors: Wu Guan , Wu Xingjiang , Xu Yijun , Cheng Hengyang , Meng Jinku , Yu Qiang , Shi Xinyiao , Zhang Kai , Chen Wei , Chen Su 
Published: April 2019

AbstractBioinspired methods allowing artificial actuators to perform controllably are potentially important for various principles and may offer fundamental insight into chemistry and engineering. To date, the main challenges persist regarding the achievement of large deformation in fast response‐time and potential‐engineering applications in which electrode materials and structures limit ion diffusion and accumulation processes. Herein, a novel electrochemical actuator is developed that presents both higher electromechanical performances and biomimetic applications based on hierachically structured covalently bridged black phosphorous/carbon nanotubes. The new actuator demonstrates astonishing actuation properties, including low power consumption/strain (0.04 W cm−2 %−1), a large peak‐to‐peak strain (1.67%), a controlled frequency response (0.1–20 Hz), faster strain and stress rates (11.57% s−1; 28.48 MPa s−1), high power (29.11 kW m−3), and energy (8.48 kJ m−3) densities, and excellent cycling stability (500 000 cycles). More importantly, bioinspired applications such as artificial‐claw, wings‐vibrating, bionic‐flower, and hand actuators have been realized. The key to high performances stems from hierachically structured materials with an ordered lamellar structure, large redox activity, and electrochemical capacitance (321.4 F g−1) for ions with smooth diffusion and flooding accommodation, which will guide substantial progress of next‐generation electrochemical actuators.
Light‐Triggered In Situ Gelation to Enable Robust Photodynamic‐Immunotherapy by Repeated Stimulations
Authors: Meng Zhouqi , Zhou Xuanfang , Xu Jun , Han Xiao , Dong Ziliang , Wang Hairong , Zhang Yaojia , She Jialin , Xu Ligeng , Wang Chao , Liu Zhuang 
Published: April 2019

AbstractPhotodynamic therapy (PDT) has shown the potential of triggering systemic antitumor immune responses. However, while the oxygen‐deficient hypoxic tumor microenvironment is a factor that limits the PDT efficacy, the immune responses after conventional PDT usually are not strong enough to eliminate metastatic tumors. Herein, a light‐triggered in situ gelation system containing photosensitizer‐modified catalase together with poly(ethylene glycol) double acrylate (PEGDA) as the polymeric matrix is designed. Immune adjuvant nanoparticles are further introduced into this system to trigger robust antitumor immune responses after PDT. Following local injection of the mixed precursor solution into tumors and the subsequent light exposure, polymerization of PEGDA can be initiated to induce in situ gelation. Such hybrid hydrogel with long‐term tumor retention of various agents and the ability to enable persistent tumor hypoxia relief can enable multiple rounds of PDT, which results in significantly enhanced immune responses by multiround stimulation. Further combination of such gel‐based multiround PDT with anticytotoxic T‐lymphocyte antigen‐4 checkpoint blockade offers not only the abscopal effect to inhibit growth of distant tumors but also effective long‐term immune memory protection from rechallenged tumors. Therefore, such a light‐triggered in situ gelation system by a single‐dose injection can enable greatly enhanced photoimmunotherapy by means of repeated stimulations.
Chemical, Structural, and Electronic Aspects of Formation and Degradation Behavior on Different Length Scales of Ni‐Rich NCM and Li‐Rich HE‐NCM Cathode Materials in Li‐Ion Batteries
Authors: de Biasi Lea , Schwarz Björn , Brezesinski Torsten , Hartmann Pascal , Janek Jürgen , Ehrenberg Helmut 
Published: April 2019

AbstractIn order to satisfy the energy demands of the electromobility market, both Ni‐rich and Li‐rich layered oxides of NCM type are receiving much attention as high‐energy‐density cathode materials for application in Li‐ion batteries. However, due to different stability issues, their longevity is limited. During formation and continuous cycling, especially the electronic and crystal structure suffers from various changes, eventually leading to fatigue and mechanical degradation. In recent years, comprehensive battery research has been conducted at Karlsruhe Institute of Technology, mainly aiming at better understanding the primary degradation processes occurring in these layered transition metal oxides. The characteristic process of formation and mechanisms of fatigue are fundamentally characterized and the effect of chemical composition on cell chemistry, electrochemistry, and cycling stability is addressed on different length scales by use of state‐of‐the‐art analytical techniques, ranging from “standard” characterization tools to combinations of advanced in situ and operando methods. Here, the results are presented and discussed within a broader scientific context.
POEMS Syndrome: 2019 Update on diagnosis, risk‐stratification, and management
Authors: Dispenzieri Angela 
Published: April 2019

AbstractDisease OverviewPolyneuropathy, organomegaly, endocrinopathy, M‐protein, skin changes (POEMS) syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Diagnoses are often delayed because the syndrome is rare and can be mistaken for other neurologic disorders, most commonly chronic inflammatory demyelinating polyradiculoneuropathy. POEMS syndrome should be distinguished from the Castleman disease variant of POEMS syndrome, which has no clonal PCD and typically little to no peripheral neuropathy but has several of the minor diagnostic criteria for POEMS syndrome.DiagnosisThe diagnosis of POEMS syndrome is made with three of the major criteria, two of which must include polyradiculoneuropathy and clonal PCD, and at least one of the minor criteria.Risk StratificationBecause the pathogenesis of the syndrome is not well understood, risk stratification is limited to clinical phenotype rather than specific molecular markers. Risk factors include low serum albumin, age, pleural effusion, pulmonary hypertension, and reduced eGFR.Risk‐Adapted TherapyFor those patients with a dominant sclerotic plasmacytoma, first line therapy is irradiation. Patients with diffuse sclerotic lesions or disseminated bone marrow involvement and for those who have progression of their disease 3 to 6 months after completing radiation therapy should receive systemic therapy. Corticosteroids are temporizing, but alkylators are the mainstay of treatment, either in the form of low dose conventional therapy or high dose with stem cell transplantation. Lenalidomide shows promise with manageable toxicity. Thalidomide and bortezomib also have activity, but their benefit needs to be weighed against their risk of exacerbating the peripheral neuropathy. Prompt recognition and institution of both supportive care measures and therapy directed against the plasma cell result in the best outcomes.
A novel missense mutation in TFAP2B associated with Char syndrome and central diabetes insipidus
Authors: Edward Heather L. , D'Gama Alissa M. , Wojcik Monica H. , Brownstein Catherine A. , Kenna Margaret A. , Grant P. Ellen , Majzoub Joseph A. , Agrawal Pankaj B. 
Published: April 2019

AbstractChar syndrome is characterized by persistent patent ductus arteriosus (PDA) associated with hand‐skeletal abnormalities and distinctive facial dysmorphism. Pathogenic variants in the transcription factor gene TFAP2B have been shown to cause Char syndrome; however, there is significant phenotypic variability linked to variant location. Here, we report a pediatric patient with a novel de novo variant in the fifth exon of TFAP2B, c.917C > T (p.Thr306Met), who presented with PDA, patent foramen ovale, postaxial polydactyly of the left fifth toe and clinodactyly of the left fourth toe, sensorineural hearing loss, scoliosis, dental anomalies, and central diabetes insipidus (CDI). CDI, scoliosis, and hearing loss have not previously been reported in a patient with Char syndrome, and while the association may be coincidental, this report expands the genotypes and potentially phenotypes associated with this syndrome.
In situ erzeugte Goldnanopartikel auf Aktivkohle als wiederverwendbare hocheffiziente Katalysatoren für eine C‐C‐Stille‐Kupplung
Authors: Holz Julia , Pfeffer Camilla , Zuo Hualiang , Beierlein Dennis , Richter Gunther , Klemm Elias , Peters René 
Published: April 2019

AbstractGoldnanopartikel sind für viele industrielle Prozesse wichtige Katalysatoren. In traditionellen C‐C‐Kreuzkupplungen wurden sie jedoch selten eingesetzt, da Pd‐Katalysatoren in der Regel überlegen sind. Hier beschreiben wir in situ gebildete Goldmetallnanopartikel als hochaktive Katalysatoren für die Kreuzkupplung von Allylstannanen und aktivierten Alkylbromiden zur Bildung von C‐C‐Bindungen. In Gegenwart von Aktivkohle als Trägermaterial, was eine einfache Katalysatorrückgewinnung und ‐wiederverwendung ermöglichte, konnten Umsatzzahlen von bis zu 29.000 erreicht werden. Die vorliegende Studie ist ein seltenes Beispiel für eine Kreuzkupplungsreaktion eines organischen Halogenids mit einem metallorganischen Reagens, bei der ein Goldmetallkatalysator Pd‐Katalysatoren überlegen ist.
The Role of Organic Synthesis in the Emergence and Development of Antibody–Drug Conjugates as Targeted Cancer Therapies
Authors: Nicolaou K. C. , Rigol Stephan 
Published: April 2019

AbstractWith a number of antibody–drug conjugates (ADCs) approved for clinical use as targeted cancer therapies and numerous candidates in clinical trials, the field of ADCs is emerging as one of the frontiers in biomedical research, particularly in the area of cancer treatment. Chemists, biologists and clinicians, among other scientists, are partnering their expertise to improve their design, synthesis, efficacy and precision as they strive to advance this paradigm of personalized and targeted medicine to treat cancer patients more effectively and to expand its scope to other indications. Just as Alexander Fleming's penicillin, and the myriad other bioactive natural products that followed its discovery and success in the clinic, ignited a revolution in medicine after the Second World War, so did calicheamicin γ1I, and other highly potent naturally occurring antitumor agents, play a pivotal role in enabling the advent of this new paradigm of “biological‐small molecule hybrid” medical intervention. Today there are four clinically approved drugs from the ADC paradigm, Mylotarg, Adcetris, Kadcyla and Besponsa, in order of approval, the first and the last of which carry the same calicheamicin γ1I‐derived payload. Covering oncological applications, and after a brief history of the emergence of the field of antibody–drug conjugates triggered more than a century ago by Paul Ehrlich's “magic bullet” concept, this Review is primarily focusing on the chemical synthesis aspects of the ADCs multidisciplinary research enterprise.
Antileismanial activity, mechanism of action study and molecular docking of 1,4‐bis(substituted benzalhydrazino)phthalazines
Authors: Romero Angel H. , Rodríguez Noris , Oviedo Henry , Lopez Simón E. 
Published: April 2019

AbstractTo identify new agents for the treatment of American cutaneous leishmaniasis, a series of eight 1,4‐bis(substituted benzalhydrazino)phthalazines was evaluated against Leishmania braziliensis and Leishmania mexicana parasites. These compounds represent a disubstituted version of the 1‐chloro‐4‐(monoaryl/heteroarylhydranizyl)phthalazine that exhibited a significant response against L. braziliensis according to our previous findings. Two disubstituted phthalazines 3b and 3f were identified as potential antileishmanial agents against L. braziliensis parasites, exhibiting a submicromolar IC50 response of 2.37 and 7.90 µM on the promastigote form, and of 1.82 and 4.56 µM against intracellular amastigotes, respectively. In particular, compound 3b showed interesting responses against amastigote isolates from reference, glucantime‐resistant and clinical human strains, which were by far superior to the biological response found for the glucantime drug. With regard to the toxicity results, both 3b and 3f exhibited moderate LD50 values against murine macrophages (BMDM), with good selectivity indexes on promastigotes and intracellular amastigotes of L. braziliensis. A comparison of biological response was established between the monosubstituted and disubstituted versions of these benzalhydrazino‐phthalazines. Easy synthetic procedure and significant response against amastigote strains including against resistant lines made compound 3b a potential candidate for further pharmacokinetic and in vivo experiments as antileishmanial agent, and as a platform for further structural optimization. Mechanism‐of‐action studies and molecular docking simulations discarded to inhibition of superoxide dismutase as possible mode of action.