bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiologic/histologic discrepancies in tumour identification: The case of a “basketball‐sized” mandibular tumour in a woman from 17th century West Virginia
Authors: Rothschild Bruce , Robinson Lisa , Witt Michelle , Koay Jennifer , Cline Heather 
Published: August 2018

AbstractObjectivesWhen initially discovered in 1963, techniques did not allow definitive diagnosis of the basketball‐sized mandibular tumour discovered in a woman from the Buffalo site dated to 17th century West Virginia. Her subsequent medical examiners stated that they “can only speculate as to the true nature of the tumor.” An interdisciplinary approach was pursued to assess ability of currently available techniques to resolve this conundrum.Materials and methodsMacroscopic examination, X‐ray, computed tomography (CT), micro‐CT (7‐μ resolution), and epi‐illumination microscopy (100‐μ resolution) were utilized to identify diagnostic criteria that would allow discrimination among the possible etiologies.ResultsMacroscopic examination revealed a 24 by 23 by 19‐cm tumour attached to the right mandible. X‐ray examination revealed intact trabeculae of reduced size but of uniform thickness. CT examination revealed intact trabeculae of decreased size but uniform thickness. Epi‐illumination microscopy confirmed the CT findings. Trabeculae appeared to be intact, uniform in thickness, and with intact connectivity. Micro‐CT revealed significant variation in trabecular thickness with frequent areas of resorption and loss of interconnections.DiscussionOsteosarcoma was considered macroscopically, on the basis of tumour size. However, the small, uniformly sized, intact trabeculae recognized on X‐ray, CT, and with epi‐illumination microscopy presented the pattern anticipated with an osteoblastoma. Micro‐CT, however, falsified that diagnosis, in favour of an osteosarcoma diagnosis. The final consideration is of an osteoblastic osteosarcoma, apparently the first recognized in the archaeologic record. The misleading nature of routine X‐ray, CT, and even microscopy (at 100‐μ resolution) in this case stands as a caveat.
HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS profiling of Verbascum ovalifolium Donn ex Sims and evaluation of its antioxidant and cytogenotoxic activities
Authors: Luca Simon Vlad , Miron Anca , Aprotosoaie Ana Clara , Mihai Cosmin‐Teodor , Vochita Gabriela , Gherghel Daniela , Ciocarlan Nina , Skalicka‐Woźniak Krystyna 
Published: August 2018

AbstractIntroductionPlant species of Verbascum genus have been intensively investigated in the last decades but most studies focused on evaluation of their biological activities; there are only few studies dealing with their chemical characterisation.ObjectiveDetailed investigation of the qualitative and quantitative chemical composition, antioxidant and cytogenotoxic activities of a previously non‐studied Verbascum species (V. ovalifolium Donn ex Sims).MethodsQualitative analysis of secondary metabolites was performed by HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS, whereas quantitative data were obtained through HPLC‐DAD. Antioxidant activity was evaluated using in vitro assays; cytotoxic and genotoxic effects were assessed by 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium (MTT) and comet assays, respectively.ResultsMore than 50 secondary bioactive metabolites belonging to various classes (iridoids, phenylethanoids, flavonoids, phenolic acids) were detected in the methanolic extract of V. ovalifolium and its fractions. The fragmentation pathways of acylated catalpol‐type iridoid diglycosides are thoughtfully described herein. The extracts showed good free radical scavenging and ferric ion reducing properties correlated with phenolic, flavonoid, chlorogenic acid and verbascoside contents. Moreover, 24 h treatment of SK‐MEL‐2 cells with V. ovalifolium extracts produced significant changes in terms of tumour cell viability. The crude extract and the ethyl acetate fraction showed no important signs of cytogenotoxicity in non‐tumour cells.ConclusionThe performed phytochemical and biological analyses contribute to the preclinical knowledge about V. ovalifolium and they could help exploiting it in novel herbal medicinal products.
Microarray analysis: First‐trimester maternal serum free β‐hCG and the risk of significant copy number variants
Authors: Bornstein Eran , Gulersen Moti , Krantz David , Cheung Sau W. , Maliszewski Kristen , Divon Michael Y. 
Published: August 2018

AbstractObjectiveTo determine whether abnormal levels of first‐trimester maternal serum free β‐hCG and PAPP‐A are associated with significant copy number variants (CNVs) on chromosomal microarray analysis (CMA).MethodsRetrospective cohort of singleton prenatal CMA studies (n = 2880). Cases with an abnormal karyotype, benign familial or de novo variants, and absence of heterozygosity were excluded. The prevalence of abnormal serum analytes was compared between patients with significant CNVs (n = 56) and those with normal CMA (n = 884). Odds ratios (ORs) and 95% confidence intervals (CI) were calculated using Fisher's exact test. Mantel‐Haenszel method was utilized to adjust ORs for prenatal diagnostic procedure type and indications for testing. Statistical significance was determined as P value < 0.05.ResultsAbnormally low serum free β‐hCG (≤0.45 MoM) was associated with an increased risk of significant CNVs (OR 3.53, 95% CI, 1.25‐8.66, P < 0.01). This association remained significant after adjusting for abnormal nuchal translucency and advanced maternal age (AMA) (adjusted OR 3.04, 95% CI, 1.05‐7.48, P < 0.05) or procedure type and AMA (adjusted OR 3.21, 95% CI 1.13–8.16, P < 0.05). The associations of abnormally high serum free β‐hCG, low PAPP‐A, and high PAPP‐A with significant CNVs were not statistically significant.ConclusionLow first‐trimester serum β‐hCG is associated with an increased risk of significant CNVs on CMA.
STEPPS treatment programme for borderline personality disorder: Which scale items improve? An item‐level analysis
Authors: Black Donald W. , Blum Nancee , Allen Jeff 
Published: August 2018

AbstractWe examined which items on the Borderline Evaluation of Severity Over Time and the Zanarini Rating Scale for Borderline Personality Disorder improved during participation in Systems Training for Emotional Predictability and Problem Solving (STEPPS). Data on 193 subjects from two independent sources were included: (1) a randomized controlled trial at an academic medical centre and (2) uncontrolled data from Iowa's correctional system. STEPPS effect size was estimated by contrasting effect size for those in the randomized controlled trial assigned to STEPPS + treatment as usual to effect size for those assigned to treatment as usual alone. Items from the Borderline Evaluation of Severity Over Time scale showing the greatest improvement assessed affective instability, ‘taking steps to avoid/prevent problems’, ‘choosing to use a positive activity’, identity disturbance and abandonment fears. The Zanarini Rating Scale for Borderline Personality Disorder items showing the greatest improvement assessed mood instability, chronic feelings of emptiness and identity disturbance. STEPPS effect size was significant for the Borderline Evaluation of Severity Over Time items rating paranoia and ‘taking steps to avoid/prevent problems’ and the Zanarini Rating Scale for Borderline Personality Disorder items assessing paranoia, impulsivity, chronic emptiness and unstable relationships. This, and future work, could eventually help in matching patients to particular treatment programmes that target their preponderant symptoms. © 2018 John Wiley & Sons, Ltd.
Theoretical studies on the mechanism and kinetic for CH3CH2O + HO2 and CH3CHOH + HO2 reactions
Authors: Zhang Tianlei , Wen Mingjie , Ju Yan , Kang Jiaxin , Wang Rui , Cao Jia , Roy Soumendra K. 
Published: August 2018

AbstractThe singlet and triplet reaction mechanisms and rate constants for CH3CH2O + HO2 and CH3CHOH + HO2 reactions were investigated by employing the high‐level quantum chemical calculations with CBS‐QB3 theoretical method and conventional transition state theory with the Wigner tunneling correction. For CH3CH2O + HO2 reaction, four direct hydrogen abstraction processes and five addition‐elimination channels were identified, while two direct hydrogen abstraction routes and nine addition‐elimination channels were found in CH3CHOH + HO2 reaction. The results show that the triplet addition‐elimination channels of CH3CH2OH + 3O2 and CH3COOH + H2O are, respectively, the most favorable channels for CH3CH2O + HO2 and CH3CHOH + HO2 reactions. This is because that they have lower energy barrier and their contribution to the overall rate constants are, respectively, 57% to 86% and 44% to 80%. This work may lead to a better understanding of the mechanism and the kinetic for the singlet and triplet reactions of CH3CH2O + HO2 and CH3CHOH + HO2.
“The child is our focus”: On couple issues in child oncology treatment
Authors: Hooghe An , Rosenblatt Paul C. , De Jongh Sofie , Bakker Esther , Nijkamp Marjan , Rober Peter 
Published: August 2018

AbstractObjectiveThis study explored the perspectives of child oncology professionals and parents about the attention professionals should give to the parent couple relationship during treatment of the child.MethodsWe employed a qualitative research design, framed within the approach of consensual qualitative research (CQR), gathering data from four focus groups with 20 professionals and from nine in‐depth interviews with 16 parents. Thematic analysis of the focus group and interview data was done with MaxQda software, using two coders and member checks to strengthen confidence in the analysis.FindingsBoth professionals and parents talked about an elevated tension in the partner relationship during oncology treatment of the child. However, explicit attention to the partner relationship in this context felt inappropriate to professionals and parents. All emphasized the importance of the professional helpers' openness to conversation and an attuned response to the parental couple relationship.ConclusionDuring treatment, the child is the primary focus for parents and professionals. The parents' focus on supporting their child makes talking about their own emotions or about issues in the partner relationship potentially disruptive and unhelpful. Therefore, it is crucial for professionals to support the parents in their parents' role, but with an openness to converse about issues in the partner relationship at the moments when these issues might threaten their focus on the child.
Risk factors for chronic lung disease and asthma differ among children born extremely preterm
Authors: Jackson Wesley M. , O'Shea Thomas Michael , Allred Elizabeth N. , Laughon Matthew M. , Gower William Adam , Leviton Alan 
Published: August 2018

ObjectivesTo evaluate the hypothesis that chronic lung disease of prematurity (CLD) is a risk factor for asthma in children born extremely preterm, and the hypothesis that the risk factors for CLD are similar to those for asthma.MethodsA retrospective analysis was performed using data collected prospectively from 882 children born before the 28th week of gestation between 2002 and 2004 who returned for follow‐up at ages 12 and 24 months and 10 years. We created time‐oriented logistic regression models to compare risk factors for CLD, defined as need for supplemental oxygen at 36 weeks postmenstrual age, and parent‐reported asthma at 10 years of age.ResultsCLD diagnosed during neonatal admission was associated with bronchodilator use at 12 months and 24 months (P < 0.001), but not with an asthma diagnosis at 10 years (Odds Ratio 1.3; 95% confidence interval 0.98‐1.8). While risk factors for CLD include lower gestational age (OR 2.7; 1.5‐4.7) and fetal growth restriction (OR 2.3; 1.4‐3.7), risk factors for asthma include mother's eligibility for public insurance (Medicaid) (OR 1.8; 1.1‐2.8), and higher weight gain velocity during the first year (OR 1.5; 1.02‐2.2) and between the 2nd and 10th year (OR 1.7; 1.2‐2.4).ConclusionsAmong children born extremely preterm, the diagnosis of CLD and its antecedents were associated with transient preschool wheezing, but not with asthma. Post‐NICU factors, such as growth velocity and socioeconomic disadvantage, appear to have stronger associations with asthma than exposures during NICU admission.
On ‘Orbital’ and ‘Spin’ Angular Momentum of Light in Classical and Quantum Theories – A General Framework
Authors: Arvind  , Chaturvedi S. , Mukunda N. 
Published: August 2018

AbstractWe develop a general framework to analyze two much discussed questions concerning (a) ‘orbital’ and ‘spin’ angular momentum carried by light and (b) the paraxial approximation of the free Maxwell system both in the classical as well as quantum domains. After formulating the classical free Maxwell system in the transverse gauge in terms of complex analytical signals we derive expressions for the constants of motion (COM) associated with its Poincaré symmetry. In particular, we show that the COM corresponding to the total angular momentum J naturally splits into an ‘orbital’ part L and a ‘spin’ part S each of which is a COM in its own right. We then discuss quantization of the free Maxwell system and construct the operators generating the Poincaré group and analyze their algebraic properties and find that while the quantum counterparts and of L and S go over into bona fide observables, they fail to satisfy the angular momentum algebra making their interpretation as ‘orbital’ and ‘spin’ operators untenable at the quantum level. On the other hand does satisfy the angular momentum algebra and together with generates the group E(3). We then present an analysis of single photon states, paraxial quantization both in the scalar as well as vector cases, and single photon states in the paraxial regime. All along a close connection is maintained with the Hilbert space that naturally arises in the classical context.
Assessment of sediment yield in Thailand using revised universal soil loss equation and geographic information system techniques
Authors: Rangsiwanichpong Prem , Kazama So , Gunawardhana Luminda 
Published: August 2018

AbstractSoil is one of the most important natural resources on Earth. Information on soil loss is important to support agricultural productivity and natural resource management. Therefore, this research aimed to estimate and map mean annual soil erosion and sediment deposition using a geographic information system (GIS). The soil loss in each grid cell was analysed by the revised universal soil loss equation (RUSLE) model. The parameters of the RUSLE including rainfall, soil type, and land use were calculated in each grid cell from a digital elevation model with of 1‐km2 resolution. Furthermore, sediment deposition was derived from the RUSLE model and used in GIS software to generate soil loss capacity maps. The results show that soil erosion occurred over all parts of Thailand, especially in the northern and southern parts due to the topography, geology, and land cover. The sediment was deposited in grid cells where the elevation was low, primarily near rivers. The results of this research support local land development policies that are implemented to control sediment yields during development.
Elements of socially sustainable innovation processes in Finnish urban development
Authors: Parjanen Satu , Hyypiä Mirva , Martikainen Suvi‐Jonna , Hennala Lea 
Published: August 2018

AbstractThe purpose of this article is to study socially sustainable innovation processes in urban development. Which elements can be identified to support socially sustainable innovation processes in urban development and how were the elements realized in urban innovation processes in Finland in 2013 and 2015 are the research questions. According to the literature review, socially sustainable innovation processes include an open and interactive development approach, resident and user‐driven involvement, communication, learning and feedback, and impact assessment. To track the elements in practice a qualitative approach using case‐based research was conducted. The results reveal that urban development processes in Finland could not be considered socially sustainable because the elements are realized differently. Although many current processes include resident participation, impact assessment is lacking. The study also presents a strategy for how to create more socially sustainable urban innovation processes.
Nano‐Vehicles for Drug Delivery Using Low‐Cost Cationic Surfactants: A Drug Induced Structural Transitions
Authors: Rajput Sargam M. , Gangele Krishnakant , Kumar Sugam , Aswal Vinod K , Mata Jitendra P. , Malek Naved I. , Kailasa Suresh Kumar , Poluri Krishna Mohan 
Published: August 2018

AbstractTailor‐made application of catanionic aggregates as drug delivery vehicle and as templates for organized nano‐assemblies makes them the best alternatives to liposomes and niosomes. Catanionic aggregates formed by using hydrotropic drug as one of the components pave way for the increased bioavailability thorough sustained contact time and release of the charged drug. In the present investigation, the molecular interaction between the anti‐inflammatory hydrotropic drug, diclofenac sodium (DS) with traditional low cost cationic surfactants with varying chain length is studied. A strong structural transition was observed using turbidity, viscosity, dynamic light scattering, zeta potential, 1H‐NMR, AFM, TEM and SANS techniques. The results suggested that spherically/elliptical shaped micellar aggregates are converted into vesicles through intermediate cylindrical/wormlike aggregates. We have characterized (size and shape) the drug‐surfactant system based on the concentration of the drug, and alkyl chain length of cationic surfactants. The drug loaded vesicles were tested at physiological temperature and were found to stable even at high loading. Due to low cost and high stability, present system could be used as low cost drug delivery vehicle.
Simple Schiff‐Base Cu(II) Complexes as Efficient Catalysts for Benzyl Alcohol Oxidation
Authors: Czepa Włodzimierz , Fik Marta A. , Witomska Samanta , Kubicki Maciej , Consiglio Giuseppe , Pawluć Piotr , Patroniak Violetta 
Published: August 2018

AbstractHerein, we present synthesis and characterization of new ligand with N2O‐donor moiety based on benzothiazole unit and its two complexes with Cu(II) cations. X‐ray diffraction measurements revealed solid state structures of presented compounds as mono‐ and dinuclear entities. Both complexes appeared to be highly effective catalysts in oxidation process of benzyl alcohol and its derivatives in aqueous media. Copper(II)‐(2,2,6,6‐tetramethylpiperidine‐1‐oxyl) system provides selective conversion in the presence of 0.25 mol% and 1 mol% for complex 1 and 2, respectively. Obtained results revealed that both copper complexes are highly selective towards benzyl alcohols oxidation to its carbonyl analogues. It was tested in the presence of several electron donating and accepting substituents. Consequently, presented systems can provide effective catalytic oxidation of aforementioned groups in the presence of aliphatic alcohols.
[2+2] Cycloadditions of Sorbyl Tosylate with Imines/1‐Azadienes: A One‐Pot Domino Approach for α‐Alkylidene‐β‐lactams and Their Computational Studies and Antimicrobial Evaluation
Authors: Kumar Yogesh , Bedi Preet Mohinder Singh , Singh Prabhpreet , Adeniyi Adebayo A. , Singh‐Pillay Ashona , Singh Parvesh , Bhargava Gaurav 
Published: August 2018

AbstractThe manuscript describes a straightforward and atom‐efficient method for the synthesis of α‐alkylidene‐β‐lactams using sorbyl tosylate and imines/1‐azadienes at high temperature (80 °C). The Density functional theory calculations have shown the prevalence of the first order kinetics in these [2+2] cycloadditions to produce mixture of 3‐butadienyl‐azetidin‐2ones and 3‐but‐2‐enylidene‐azetidin‐2‐ones in good yields. The 3‐but‐2‐enylidene‐azetidin‐2‐ones have also shown antimicrobial activity against the E. coli, S. aureus, P. aeruginosa, B. cereus and B. subtilis.
Phosphine‐Free Bis(Pyrrolyl)pyridine Based NNN‐Pincer Palladium(II) Complexes as Efficient Catalysts for Suzuki‐Miyaura Cross‐Coupling Reactions of Aryl Bromides in Aqueous Medium
Authors: Yadav Seema , Singh Ajeet , Rashid Nusrat , Ghotia Maheshwari , Roy Tapta Kanchan , Ingole Pravin P. , Ray Sriparna , Mobin Shaikh M. , Dash Chandrakanta 
Published: August 2018

AbstractPalladium complexes of phosphine free pincer based ligands are currently growing credence as efficient catalysts for C–C cross‐coupling reaction under environmentally benign and mild reaction conditions. A series of new palladium complexes 2 a–2 c supported by 2,6‐bis(pyrrolyl)pyridine based [NNN]‐pincer ligands have been synthesized, and their catalytic activities for Suzuki‐Miyaura cross‐coupling reaction were examined. The palladium complexes (2 a–2 c) were synthesized by the reaction of 2,6‐bis(pyrrolyl)pyridine ligands (LH2) with Pd(OAc)2 in acetonitrile as a solvent. Electrochemical studies of complexes 2 a–2 c showed two prominent oxidation peaks, which were ascribed to the dianionic pyrrolide ligand and an oxidation peak that can be ascribed to palladium metal center. There is an exhibition of well‐coordinated metal directed oxidation of the complexes which indicates a well‐established electronic network. Computational studies on complexes 2 a–2 c further supported the experimental observations. These palladium complexes 2 a–2 c can efficiently catalyze Suzuki‐Miyaura cross‐coupling reaction of aryl bromides in an aqueous medium.
Syntheses, Crystal Structures and Magnetic Properties of Heterodinuclear Nickel(II)–Manganese(II)‐Based One‐ and Two‐Dimensional Coordination Polymers: Magnetostructural Correlation
Authors: Ghosh Sagar , Hari Nairita , Mohanta Sasankasekhar 
Published: August 2018

AbstractThis investigation deals with the syntheses, crystal structures and magnetic properties of three diphenoxo‐bridged dinuclear NiIIMnII based coordination polymers of composition [NiIIL1MnII(μ1,5‐dca)2]n (1), [NiIIL2MnII(μ1,5‐dca)2]n (2) and [NiII(MeOH)2L1MnII(μ‐Htma)]n⋅nDMF (3), where H2L1=N,N′‐bis(3‐methoxysalicylidene)‐1,3‐propanediamine and H2L2=N,N′‐bis(3‐methoxysalicylidene)‐1,4‐butanediamine and H3tma=trimesic acid. The N(imine)2O(phenoxo)2 and O(phenoxo)2O(methoxy)2 compartments of [L1]2–/[L2]2– in 1–3 are occupied by, respectively, NiII and MnII ions. Dicyanamide ligands link the dinuclear units to form different types of coordination polymers in 1 and 2; two‐dimensional in the former but one‐dimensional in the latter. The MnII center in 3 is coordinated to two oxygen atoms of two carboxylate groups of two Htma, forming a zigzag one‐dimensional structure. Variable‐temperature (2‐300 K) magnetic susceptibility data of 1–3 reveal weak antiferromagnetic interaction in the dinuclear core. Taking H=–2JS1⋅S2 as the Hamiltonian for magnetic exchange, the data were nicely simulated with J=–2.80 cm–1 and zJ=–0.04 cm–1 for 1, J=–3.71 cm–1 and zJ=0.08 cm–1 for 2 and J=–3.41 cm–1 for 3, revealing weak antiferromagnetic interaction in the dinuclear core and very weak antiferromagnetic or ferromagnetic interaction among the dinuclear cores. A J versus Ni–O(phenoxo)–Mn angle magneto‐structural correlation is proposed.