bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global research hotspots and trends in anti-inflammatory studies in dry eye: a bibliometric analysis (2004–2024)
Authors: Wang Shan , Zheng Wei , Li Ting , Yu Dongxu , Zhang Qi , Ju Yuan , Wei Lijuan 
Published: November 2024

BackgroundInflammation plays a crucial role in the pathophysiology of dry eye (DE). This study aims to provide a comprehensive overview of the current status, hotspots and trends in DE anti-inflammatory research through bibliometric analysis.MethodAll publications were searched using the Web of Science Core Collection (WoSCC) database from 2004 to 2024. Bibliometric analyses were performed using VOSviewer, R-bibliometrix, and CiteSpace, and data were managed using Microsoft Office Excel 2019.ResultsThere were 603 papers published between 2004 and 2024 included in this study, with the number of papers increasing each year. The United States was the major contributor, with the largest number of publications and the greatest impact. Baylor College of Medicine was the most influential research institution. Pflugfelder, Stephen C. and Tsubota, Kazuo were the most prolific authors in this area of research, while Dana, Reza was the most cited author in the field with the highest impact. The Journal with the highest number of publications was Investigative Ophthalmology &amp; Visual Science, while the highest impact journal was Ocular Surface. Research hotspots were focused on the mechanisms of inflammation in DE and interventions for anti-inflammatory therapy. Future studies would favor more inflammation-related targeted therapies and physical therapies.ConclusionThis study is the first bibliometric analysis to comprehensively summarize research trends and developments in DE anti-inflammatory treatments, pointing out recent research frontiers and hot directions for scholars studying DE anti-inflammatory treatments.
Exploring the role of aging in the relationship between obstructive sleep apnea syndrome and osteoarthritis: Insights from NHANES data
Authors: Luo Xin , Chen Minghong , Xu Jinghong 
Published: November 2024

BackgroundOsteoarthritis (OA) is characterized by high morbidity and disability. While studies have demonstrated that OA is correlated with age-related diseases, few have shown the potential relationship between OA and obstructive sleep apnea syndrome (OSAS). OSAS is characterized by intermittent hypoxia and hypercapnia. We hypothesize that these stressors induce aging and increase the prevalence of OA.MethodsThe study included 10,641 participants drawn from the National Health and Nutrition Examination Survey (NHANES) dataset during 2005–2008 and 2015–2018. The correlation between OSAS and OA was analyzed using multivariable logistic regression, aging-related biomarkers were calculated, and the role of aging was explored through mediation analysis.ResultsOSAS was associated with an elevated risk of OA (for quartile 4 vs. quartile 1, odds ratio (OR) 2.31, 95% confidence interval (CI) 1.34 to 3.99; p-value for the trend = 0.004) after adjusting covariates. In the 20–59 years and &gt; 60 years subgroup, the OSAS patients showed a similar trend (for quartile 4 vs. quartile 1, OR 5.69, 95% CI 2.75 to 11.8; p-value for the trend &lt;0.001; OR 2.42, 95% CI 1.23 to 4.76; p-value for the trend = 0.004, respectively). Further mediation analysis revealed that aging acted as a mediator between OA and OSAS. The mediation proportions for biological age (BA) and phenotypic age (PA) were 13.82 and 52.94%, respectively, both with p &lt; 0.001.ConclusionThese findings suggest that individuals with OSAS may have an increased prevalence of OA, with aging also being involved in the association.
Characteristics of open globe injury in children under six
Authors: Li Rui , Qi Shounan , Zhang Ying , Wang Chenguang 
Published: November 2024

IntroductionThis study aimed to analyse the clinical characteristics of open globe injury (OGI) in children under six.MethodsA retrospective analysis was conducted on the medical data of children with OGI admitted to the Eye Center of the Second Hospital of Jilin University, China, between 1 January 2012 and 31 December 2020.ResultsThe study included 106 children, with 61 males (57.5%) and 45 females (42.5%), and the mean age was 4.14 ± 1.58 years. Injuries predominantly affected the right eye (53.8%). Sharp objects were the leading cause of injuries (56.6%). Most wounds (91.5%) occurred in zone I, and penetrating trauma was the most common injury type (64.2%). The concomitant OGI findings included traumatic cataracts (47.2%), iris prolapse (53.8%), endophthalmitis (22.4%), vitreous prolapse (17.0%), retinal detachment (5.7%), eyelid laceration (7.5%), and orbital fractures (1.9%). Univariate analysis showed that wooden materials (p = 0.045), needles (p = 0.045), postinjury admission time (p &lt; 0.001), injury zone (p = 0.025), and iris prolapse (p = 0.022) were significantly associated with endophthalmitis. Multivariate logistic regression analysis revealed that delayed admission for ≥24 h was an independent risk factor for endophthalmitis (p = 0.007). Preoperative and postoperative visual acuities were significantly correlated (p &lt; 0.001).ConclusionsOGIs are more common in males under six years old, with sharp objects being the primary cause. Prompt surgical intervention can lower the risk of endophthalmitis. Increased awareness of the severity of OGI and understanding the risk factors for endophthalmitis will aid in developing effective strategies to minimise ocular complications.
Epilepsy is associated with the accelerated aging of brain activity in sleep
Authors: Hadar Peter N. , Westmeijer Mike , Sun Haoqi , Meulenbrugge Erik-Jan , Jing Jin , Paixao Luis , Tesh Ryan A. , Da Silva Cardoso Madalena , Arnal Pierrick , Au Rhoda , Shin Chol , Kim Soriul , Thomas Robert J. , Cash Sydney S. , Westover M. Brandon 
Published: November 2024

ObjectiveAlthough seizures are the cardinal feature, epilepsy is associated with other forms of brain dysfunction including impaired cognition, abnormal sleep, and increased risk of developing dementia. We hypothesized that, given the widespread neurologic dysfunction caused by epilepsy, accelerated brain aging would be seen. We measured the sleep-based brain age index (BAI) in a diverse group of patients with epilepsy. The BAI is a machine learning-based biomarker that measures how much the brain activity of a person during overnight sleep deviates from chronological age-based norms.MethodsThis case–control study drew information of age-matched controls without epilepsy from home sleep monitoring volunteers and from non-epilepsy patients with Sleep Lab testing. Patients with epilepsy underwent in-patient monitoring and were classified by epilepsy type and seizure burden. The primary outcomes measured were BAI, processed from electroencephalograms, and epilepsy severity metrics (years with epilepsy, seizure frequency standardized by year, and seizure burden [number of seizures in life]). Subanalyses were conducted on a subset with NIH Toolbox cognitive testing for total, fluid, and crystallized composite cognition.Results138 patients with epilepsy (32 exclusively focal and 106 generalizable [focal seizures with secondary generalization]) underwent in-patient monitoring, and age-matched, non-epilepsy controls were analyzed. The mean BAI was higher in epilepsy patients vs controls and differed by epilepsy type: −0.05 years (controls) versus 5.02 years (all epilepsy, p &lt; 0.001), 5.53 years (generalizable, p &lt; 0.001), and 3.34 years (focal, p = 0.03). Sleep architecture was disrupted in epilepsy, especially in generalizable epilepsy. A higher BAI was positively associated with increased lifetime seizure burden in focal and generalizable epilepsies and associated with lower crystallized cognition. Lifetime seizure burden was inversely correlated with fluid, crystallized, and composite cognition.SignificanceEpilepsy is associated with accelerated brain aging. Higher brain age indices are associated with poorer cognition and more severe epilepsy, specifically generalizability and higher seizure burden. These findings strengthen the use of the sleep-derived, electroencephalography-based BAI as a biomarker for cognitive dysfunction in epilepsy.
Effects of dual-task paradigm on the injury potential during landing among individuals with chronic ankle instability
Authors: Zhong Cheng , Luo Xin , Gao He , Zhang Teng , Zhu Xiaoxue , Huang Xueke , Shen Peixin 
Published: November 2024

PurposeChronic ankle instability (CAI) causes maladaptive neuroplastic changes in the central nervous system, which may lead to high injury potential under dual-task conditions. This study aims to explore the effects of dual-task paradigm on the injury potential during landing among individuals with CAI.MethodsTwenty participants with CAI (4 female and 16 male, 12 were affected with their right limbs and 8 were affected with their left limbs, 20.4 ± 1.7 years, 176.9 ± 5.0 cm, and 72.0 ± 11.1 kg) and eighteen without CAI (6 female and 12 male, 20.2 ± 1.5 years, 173.5 ± 7.0 cm, and 70.3 ± 10.8 kg) were recruited. They drop-landed on a trap-door device, with their affected or matched limbs on a flippable platform, under single- (drop-landing only) and dual-task (drop-landing while subtracting of serial threes) conditions. A twelve-camera motion capture system was used to capture the kinematic data. Two-way ANOVA with mixed design (CAI vs non-CAI groups by single-vs dual-task conditions) was used to analyze the data.ResultsSignificant group-by-condition interactions were detected in the ankle inversion angle (P = 0.040, η2p = 0.012) and ankle inversion angular velocity (P = 0.038, η2p = 0.114). Both indicators decreased among individuals without CAI from single-to dual-task conditions, while remained unchanged among those with CAI; and they were higher among individuals with CAI under both single- and dual-task conditions, compared to those without CAI.ConclusionIndividuals with CAI have a reduced ability to limit ankle inversion compared to those without CAI. Under dual-task conditions, individuals without CAI limited their ankle inversion, while those with CAI did not. Drop-landing, especially under dual-task conditions, poses a high risk of excessive ankle inversion for individuals with CAI.
Women football observers’ experiences: a perspective from system justification and glass ceiling
Authors: Eratli Şirin Yeliz , ÖZ Günseli 
Published: November 2024

IntroductionThe legitimization theory of the system explains that despite people’s inherent drive towards personal and group interests, they tend to support social systems. Understanding the sources of social pressure and the glass ceiling perceptions of female football observers is the main aim of this study in terms of examining attitudes within the legitimized system. To this end, the study sought to answer how female football observers are constructed in a marginalized position within the male-dominated football culture through sources of social pressure, and how they accommodate the acceptance of legitimizing the system despite encountering glass ceiling barriers in the context of Turkey.MethodData for the research were collected through in-depth individual interviews (9 female observers) using qualitative research methods. The collected data were analyzed using thematic analysis. After a comprehensive analysis of the interview transcripts, four themes emerged:FindingsGender-based positive and negative experiences; Glass Ceiling: Organizational Factors; Legitimization of Hierarchy-Reducing Myths; and Hope for Future Intragroup Progress within the Current System.RecommendationsOur analysis reveals that female football observers, identified as match officials, indicate changes in authoritarian attitudes within recent institutional policies during their stadium experiences, characterized towards a more rational, female observer, and referee-focused stance. Additionally, entrenched stereotypes and legitimizing myths reducing hierarchy appear to generally establish legitimacy for female match officiating within the legitimization process. The research results suggest the importance for policymakers in the central referee committee in Turkey to consider the dimensions of legitimization both verbally and in writing when creating policies regarding women.
The paradox of convenience: how information overload in mHealth apps leads to medical service overuse
Authors: Zhong Lingling , Cao Junwei , Xue Fengtao 
Published: November 2024

BackgroundMobile health applications (mHealth) have become an indispensable tool in the healthcare industry to provide users with efficient and convenient health services. However, information overload has led to significant information overload problems in mHealth applications, which may further lead to overuse of medical services.MethodsThe purpose of this study was to explore the relationship between information overload and overuse of medical services in mHealth applications through health belief model (HBM). Data were collected from 1,494 respondents who were sampled through a simple random approach. A structured questionnaire was used as the instrument for data collection from mobile APP users in Guangdong Province between February 4, 2024, and February 20, 2024. Structural equation modeling (SEM) was used to analyze the data to investigate the effects of information overload on users’ perceived severity, susceptibility, treatment benefits, barriers, self-efficacy, and action cues, which further influence the overuse of health care services.ResultsThe study found that information overload significantly affected users’ perceived severity, susceptibility, treatment benefits, barriers, self-efficacy, and action cues, and subsequently affected overuse of health care services. These results provide valuable insights for mHealth application developers, healthcare providers, and policy makers.ConclusionThis study highlights the importance of effectively managing information delivery in mHealth applications to reduce the risk of overuse of healthcare services. The study not only highlights the dark side of information overload in mHealth applications, but also provides a framework to understand and address the challenges associated with information overload and service overuse in the mHealth context.
Social participation and cognitive activities as explanation factor for the association between income and self-rated health for older adults
Authors: Buß A. M. , Wittmann F. G. , Pabst A. , Luppa M. , Oey A. , Blotenberg I. , Cardona M. I. , Weise S. , Bauer A. , Kosilek R. P. , Bader F. , Brettschneider C. , Wiese B. , Hoffmann W. , Frese T. , Gensichen J. S. , König H.-H. , Thyrian J. R. , Riedel-Heller S. G. 
Published: November 2024

IntroductionHealth disparities pose a considerable challenge for older adults individuals, particularly those with a heightened risk of developing dementia. Discrepancies in health status among various income brackets are only partially attributable to structural factors such as working and living conditions or the quality of food. The aim of this study was therefore to explore whether and to what extent various health-promoting behaviors can explain the association between household income and self-rated health among older people at risk of dementia.MethodsThe sample consisted of 845 participants (average age 68.9 years; 52.6% female) from the AgeWell.de study, an intervention trial aiming to preserve cognitive function. The participants exhibited an increased risk of dementia, defined by a CAIDE (Cardiovascular Risk Factors, Aging and Dementia) score of at least nine points. To explore the relationship between household income and self-rated health, measured using the EQ-5D-VAS, a regression analysis was conducted. This association was then examined using four mediation analyses that included health-promoting behaviors such as fruit and vegetable consumption, social participation, physical activities, and cognitive activities.ResultsThe results reveal a positive association between higher income and self-rated health. This relationship is mediated by social participation. Additionally, cognitive activities were found to partially mediate this correlation. Neither physical activities nor fruit and vegetable consumption could account for the association between income and self-rated health.ConclusionThe findings have the potential to advance research on the correlation between income and health among older age cohorts at risk of developing dementia. They highlight the potential significance of social engagement and cognitive activities for health and may inspire the development of strategies aimed at enhancing accessibility to activities such as cultural events, educational institutions, and participation in courses for a wider audience.
The relationship between sleep duration and physical activity level among Norwegian adolescents: a cross-sectional study
Authors: Grasaas Erik , Hysing Mari , Sandbakk Øyvind 
Published: November 2024

BackgroundFailure to adhere to sleep and physical activity recommendations among adolescents constitutes a public health problem. However, the associations between sleep duration and adolescents’ physical activity levels remain less explored. The aims of this paper were twofold: (1) to describe sleep and physical activity levels among Norwegian school-based adolescents, stratified by school level and sex and (2) to explore the association between sleep and physical activity levels.MethodsData were derived from the 2022 Norwegian Ungdata Survey, totaling 63,113 adolescents from lower (aged 13 to 16 years) and upper (aged 16 to 19 years) secondary schools. Study variables were measured using single-item questions from the Ungdata survey and collected through an electronic questionnaire administered during school hours. Logistic regressions were performed using crude analysis and adjusted for Socioeconomic status (SES) and grade level (age).ResultsIn lower secondary school, 57.0% of girls and 44.7% of boys reported sleeping less than the recommended 8 h, whereas in upper secondary school, the rate was 74.9% among girls and 74.3% among boys. Girls consistently reported more sleep problems, feeling more tired at school or during activities, and less physical activity than boys across school levels. Sleep duration was a significant predictor for all levels of weekly physical activity among girls across school levels, with the highest odds revealed in upper secondary school among those being active 5 times a week (B = 1.32; 95% CI [1.24 to 1.40]). Sleep duration was a predictor for being active 5 times a week for boys across school levels (B = 1.22; 95% CI [1.17 to 1.27]).ConclusionAbout half of younger adolescents and three-quarters of older adolescents do not adhere to the sleep recommendation. Lower levels of physical activity were consistently reported by girls than boys. Sleep duration consistently predicted a 20 to 30% higher likelihood of being active at least 5 days a week across sex and school levels. These findings underscore the critical role of sleep duration relations to higher physical activity levels among Norwegian adolescents. Government and policymakers should encourage healthy sleep and PA habits by explicitly incorporating guidelines into the curriculum.
Patient-informed exploration of the aftermath of a diagnostic problem or mistake based on results of a national survey
Authors: Gleason Kelly T. , Yuan Christina T. , Haskell Helen , Anderson Michelle A. , Evered Jane A. , McDonald Kathryn M. 
Published: November 2024

IntroductionDespite the prevalence and devastating consequences of diagnostic breakdowns, there have been minimal efforts to systematically collect patient insight into diagnostic problems and mistakes. Collaborating with patient advocates to guide how patient-derived insights are interpreted and used is a critical, yet often overlooked, approach to identifying actionable solutions that speak to patients' priorities.ObjectiveWe collaborated with patient advocate co-authors to guide our understanding of findings from a mixed methods survey on diagnostic problems and mistakes, and report implications for patient engagement at three levels of action: (1) individual level before, during, after encounters (micro); (2) within health service delivery systems (meso); and (3) policy advocacy (macro).MethodsOur research team applied narrative elicitation methods to conduct a novel survey about Americans' diagnostic experiences in a national, population-based survey. We shared early results with patient co-authors who highlighted the importance of further exploring how health systems and clinicians address the aftermath of diagnostic mishaps. Based on their input, we summarized the quantitative and qualitative survey results about the aftermath and worked with our patient co-authors to explore how findings might inform actionable next steps, including efforts to catalyze patient action, quality improvement efforts, and policy reform.ResultsOf the 3,684 survey respondents, about a third (33.0%, 1,216/3,684) of screened households reported diagnostic problems and mistakes in the past four years involving either themselves (18.9%, 697/3,684) or someone close to them (14.1%, 519/3,684). In the aftermath of a diagnostic mishap, over a third reported that someone in the healthcare setting where the mistake occurred acknowledged the mistake (35.9%, 432/1,204). In qualitative findings, reports that the health system “did nothing” surfacing as the most common response. Patient co-authors confirmed the results resonated with their experiences and emphasized the need for health systems to take accountability when a mishap occurs and to take follow-up actions to prevent future mishaps.DiscussionPatients and care partners not only want and deserve acknowledgement of diagnostic problems or mistakes in their own care, they also want assurance that steps are being taken to prevent similar events from happening to others. Across micro-, meso-, and macro-levels of action, working with patients to understand and act on contributors to diagnostic breakdowns is aligned with high-reliability organizing principles.
Comparative perceptions of sexual harassment among athletes across different competitive levels
Authors: Zach Sima , Davidovitz Maayan , Cohen Rona 
Published: November 2024

PurposeDespite evidence that sports arenas are grooming ground for sexual harassment, consensus is still lacking what this term constitutes. The aim of this study is to examine how athletes of different levels and non-athletes perceive sexual harassment in sports through the lens of the Institutional Theory.MethodHundred and thirty pre-service physical education teachers (competitive and non-competitive athletes) and 53 Olympic athletes, rated 27 items divided into four levels of sexual harassment regarding men coaches' behaviors towards women athletes, on a scale of 1 (does not constitute sexual harassment) to 4 (constitutes sexual harassment to a great extent).FindingsNon-Olympic athletes rated the behaviors as constituting sexual harassment to a greater degree than Olympic athletes, in all categories, as did women participants compared to man. Both genders rated sexual harassment and exploitation as the most severe factor followed by Sexist behavior, yet the more competitive the athletes, the less they perceived such behaviors as disturbing. The Professional contact factor was rated as the least disturbing, with women rating it as less disturbing than men.ConclusionsThe study underscores the ambiguity surrounding the definition of sexual harassment in sports, emphasizing the necessity for clear boundaries to establish acceptable behavior. Such clarity is essential to ensure that all athletes feel safe within the sporting environment. It emphasizes the importance of zero tolerance for all harassing behaviors, regardless of severity, and the implementation of comprehensive policies and training programs in sport organizations. Moving forward, promoting respect, safety, and awareness, along with ongoing research and evaluation, are crucial for creating inclusive and safe sporting environments.