bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Hydrographic Measurements of the Upper Arctic Western Eurasian Basin in 2017 Reveal Fresher Mixed Layer and Shallower Warm Layer Than 2005–2012 Climatology
Authors: Athanase Marylou , Sennéchael Nathalie , Garric Gilles , Koenig Zoé , Boles Elisabeth , Provost Christine 
Published: January 2019

AbstractIn 2017, Ice Atmosphere Ocean Observing System autonomous drifting platforms provided extensive physical and biogeochemical data in the upper 350 m of the western Eurasian Basin through their 8‐month drift across the Amundsen Basin, the Gakkel Ridge, the Nansen Basin and western Fram Strait. Comparison with WOA13 climatology indicates a fresher surface layer and shallower warm layer in 2017 than in 2005–2012. The Ice Atmosphere Ocean Observing System 2017 data feature two halocline eddies in the Amundsen Basin and two Atlantic Water (AW) mesoscale structures in the Nansen Basin. Analysis of the global (1/12)° Mercator Ocean operational system suggests that the halocline eddies resulted from instabilities in the frontal zone between fresher Makarov waters and saltier Eurasian waters. This frontal region appears to have shifted further southeast in 2017 (near 88°N, 10°E) compared to 2005–2012. The operational system depicts the large AW structure in the Nansen Basin (140 km crossed as far as 83.7°N, 34.5°E) as an AW meander from the Arctic Circumpolar Boundary Current, which turned into an anticyclonic eddy about a month after the platforms drifted away. The AW structure at 82.8°N, 3°W, northwest of the Yermak Plateau, corresponds to an AW recirculating branch detaching from the Yermak Plateau slope back toward Fram Strait.
Improving Land Surface Temperature Simulation in CoLM Over the Tibetan Plateau Through Fractional Vegetation Cover Derived From a Remotely Sensed Clumping Index and Model‐Simulated Leaf Area Index
Authors: Li Chengwei , Lu Hui , Leung L. Ruby , Yang Kun , Li Hongyi , Wang Wei , Han Menglei , Chen Yingying 
Published: January 2019

AbstractParameterizations of fractional vegetation cover (FVC) in land surface models have important effects on simulations of surface energy budget, especially in arid and semiarid regions. This study uses a FVC scheme in which FVC is derived from leaf area index and a remotely sensed clumping index. The performance of the new scheme (SMFVC) is evaluated against Moderate Resolution Imaging Spectroradiometer (MODIS) land surface temperature (LST) and in situ soil temperature observations, together with two other FVC schemes, a general FVC scheme (CTL) based on land cover map and a climatology‐based FVC scheme (RSFVC) that uses long‐term remotely sensed Normalized Difference Vegetation Index of MODIS. The three FVC schemes were implemented in the Common Land Model (CoLM) and applied in the Tibetan Plateau using the same forcing data and default parameters. Our results demonstrate that FVC schemes have significant influence on the CoLM performance: (1) the RSFVC and SMFVC schemes significantly reduce the LST biases found in CTL, particularly in grassland and during summer; (2) soil temperature evaluation by in situ observations from three networks on the Tibetan Plateau corroborates the LST results; and (3) the improvements are mainly related to representing temporal (seasonal) variability and subgrid heterogeneity of FVC, which improves surface albedo and surface energy balance. In other words, by including more vegetation characteristics, such as using a clumping index, land surface models may better simulate surface vegetation condition and further better represent the land surface energy budget over the Tibetan Plateau.
Scaling, Anisotropy, and Complexity in Near‐Surface Atmospheric Turbulence
Authors: Stiperski Ivana , Calaf Marc , Rotach Mathias W. 
Published: January 2019

AbstractThe development of a unified similarity scaling has so far failed over complex surfaces, as scaling studies show large deviations from the empirical formulations developed over flat and horizontally homogeneous terrain as well as large deviations between the different complex terrain data sets. However, a recent study of turbulence anisotropy for flat and horizontally homogeneous terrain has shown that separating the data according to the limiting states of anisotropy (isotropic, two‐component axisymmetric and one‐component turbulence) improves near‐surface scaling. In this paper we explore whether this finding can be extended to turbulence over inclined and horizontally heterogeneous surfaces by examining near‐surface scaling for 12 different data sets obtained over terrain ranging from flat to mountainous. Although these data sets show large deviations in scaling when all anisotropy types are examined together, the separation according to the limiting states of anisotropy significantly improves the collapse of data onto common scaling relations, indicating the possibility of a unified framework for turbulence scaling. A measure of turbulence complexity is developed, and the causes for the breakdown of scaling and the physical mechanisms behind the turbulence complexity encountered over complex terrain are identified and shown to be related to the distance to the isotropic state, prevalence of directional shear with height in mountainous terrain, and the deviations from isotropy in the inertial subrange.
T6SS contributes to gut microbiome invasion and killing of an herbivorous pest insect by plant-beneficial Pseudomonas protegens
Authors: Vacheron Jordan , Péchy-Tarr Maria , Brochet Silvia , Heiman Clara Margot , Stojiljkovic Marina , Maurhofer Monika , Keel Christoph 
Published: January 2019

Abstract
Pseudomonas protegens are multi-talented plant-colonizing bacteria that suppress plant pathogens and stimulate plant defenses. In addition, they are capable of invading and killing agriculturally important plant pest insects that makes them promising candidates for biocontrol applications. Here we assessed the role of type VI secretion system (T6SS) components of type strain CHA0 during interaction with larvae of the cabbage pest Pieris brassicae. We show that the T6SS core apparatus and two VgrG modules, encompassing the respective T6SS spikes (VgrG1a and VgrG1b) and associated effectors (RhsA and Ghh1), contribute significantly to insect pathogenicity of P. protegens in oral infection assays but not when bacteria are injected directly into the hemolymph. Monitoring of the colonization levels of P. protegens in the gut, hemolymph, and excrements of the insect larvae revealed that the invader relies on T6SS and VgrG1a module function to promote hemocoel invasion. A 16S metagenomic analysis demonstrated that T6SS-supported invasion by P. protegens induces significant changes in the insect gut microbiome affecting notably Enterobacteriaceae, a dominant group of the commensal gut bacteria. Our study supports the concept that pathogens deploy T6SS-based strategies to disrupt the commensal microbiota in order to promote host colonization and pathogenesis.
LINC01939 inhibits the metastasis of gastric cancer by acting as a molecular sponge of miR-17-5p to regulate EGR2 expression
Authors: Chen Mi , Fan Li , Zhang Si-Min , Li Yong , Chen Peng , Peng Xin , Liu Dong-Bo , Ma Charlie , Zhang Wen-Jie , Zou Zhen-Wei , Li Pin-Dong 
Published: January 2019

AbstractAccumulating evidence have suggested that long noncoding RNAs (lncRNAs) are known to regulate diverse tumorigenic processes. Recently, a novel lncRNA LINC01939 was underexpressed and emerged as a tumor suppressive lncRNA in gastric cancer (GC). In this study, we aimed to investigate the biological function and molecular mechanism of LINC01939 in GC. We found that LINC01939 expression was significantly downregulated in GC tissues and cell lines. Low expression of LINC01939 was correlated with tumor metastasis and shorter survival in GC patients. Functionally, LINC01939 overexpression remarkably inhibited the invasion and migration of GC cells in vitro and in vivo. Mechanistically, LINC01939 regulated the expression of early growth response 2 (EGR2) protein by competitively binding to miR-17-5p. Upregulation of miR-17-5p reversed GC metastasis and EMT process caused by LINC01939 by rescue analysis. Taken together, these results suggested that LINC01939 repressed GC invasion and migration by functioning as a ceRNA for miR-17-5p to regulate EGR2 expression. Our findings provided a novel prognostic marker and therapeutic target for GC patients.
RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer
Authors: Zheng Xulei , Zhao Xu , Zhang Yingying , Tan Hao , Qiu Bojun , Ma Tengjiao , Zeng Jiarong , Tao Dachang , Liu Yunqiang , Lu Yilu , Ma Yongxin 
Published: January 2019

AbstractCircadian rhythm is an autoregulatory rhythm, which is sustained by various mechanisms. The nucleocytoplasmic shuttling of BMAL1 is essential for CLOCK translocation between cytoplasm and nucleus and maintenance of the correct pace of the circadian clock. Here we showed that RAE1 and NUP98 can promote the degradation of BMAL1 and CLOCK. Knockdown of RAE1 and NUP98 suppressed BMAL1 shuttling, leading to cytoplasm accumulation of CLOCK. Furthermore, Chip assay showed that knockdown of RAE1 and NUP98 can enhance the interaction between CLOCK: BMAL1 and E-box region in the promoters of Per2 and Cry1 while reducing its transcription activation activity. Our present study firstly revealed that RAE1 and NUP98 are critical regulators for BMAL1 shuttling.
Involvement of serum amyloid A1 in the rupture of fetal membranes through induction of collagen I degradation
Authors: Wang Wang-sheng , Li Wen-jiao , Wang Ya-wei , Wang Lu-yao , Mi Ya-bing , Lu Jiang-wen , Lu Yi , Zhang Chu-yue , Sun Kang 
Published: January 2019

AbstractThe de novo synthesis of serum amyloid A1 (SAA1) is augmented in human fetal membranes at parturition. However, its role in parturition remains largely unknown. Here, we investigated whether SAA1 was involved in the rupture of fetal membranes, a crucial event in parturition accompanied with extensive degradation of collagens. Results showed that SAA1 decreased both intracellular and extracellular COL1A1 and COL1A2 abundance, the two subunits of collagen I, without affecting their mRNA levels in human amnion fibroblasts. These reductions were completely blocked only with inhibition of both matrix metalloproteases (MMPs) and autophagy. Consistently, SAA1 increased MMP-2/9 abundance and the markers for autophagic activation including autophagy related (ATG) 7 (ATG7) and the microtubule-associated protein light chain 3 β (LC3B) II/I ratio with the formation of LC3 punctas and autophagic vacuoles in the fibroblasts. Moreover, the autophagic degradation of COL1A1/COL1A2 and activation of MMP-2/9 by SAA1 were blocked by inhibitors for the toll-like receptors 2/4 (TLR2/4) or NF-κB. Finally, reciprocal corresponding changes of SAA1 and collagen I were observed in the amnion following spontaneous rupture of membranes (ROM) at parturition. Conclusively, SAA1 may participate in membrane rupture at parturition by degradating collagen I via both autophagic and MMP pathways. These effects of SAA1 appear to be mediated by the TLR2/4 receptors and the NF-κB pathway.
Principle of Fredholm image reconstruction in the vignetting zone of an externally occulted solar coronagraph
Authors: Aime C. , Theys C. , Rougeot R. , Lantéri H. 
Published: January 2019

Aims.This study is carried out in the context of data processing of the solar coronagraph ASPIICS of the future formation-flying mission Proba-3, which is expected to provide images of the corona very close to the limb. There will be a transition zone of the order of 100 arcsec close to the limb, where the telescope aperture suffers a strong vignetting by the external occulter (a disc of 1.42 m at 144 m). The instrument response in this region will vary rapidly both in shape and in integrated intensity, the latter being particular to the external occultation. The aim of this paper is to propose a technique to recover as much as possible of the image of the corona very close to the limb in the vignetting zone.Methods.The object image relationship in this zone is not defined by the usual convolution but by the more general Fredholm integral of the first kind. Theoretical aspects of the problem are detailed in the context of a matrix formalism for the inversion of the Fredholm integral, formalism that we maintain up to the end of the numerical simulations, which is specific to the present work. The iterative Richardson-Lucy algorithm, specially written for the non-constant integrated intensity of the responses is used here for reconstruction. A study of the effect of noise on a photodetected image is made.Results.An important part of the work consisted in calculating the elements of the transfer matrix between the object and the image for a simulation on a small region of size 100 × 100 arcsec sampled over 128 × 128 pixels. This is obtained propagating the light through the system using a previously published approach. On a toy object, the reconstruction is excellent down to about 60 arcsec from the limb, corresponding to a vignetting of 50%. The drawback is that the recovery of aN × Nobject requires the handling of aN2 × N2matrix, i.e. a 16384 × 16384 transfer matrix here. However, taking into account radial symmetries of the experiment, we propose the use of a transformation from Cartesian to polar coordinates which allows to apply the same procedure all around the sun as for a small region.
Evidence for diffuse molecular gas and dust in the hearts of gamma-ray burst host galaxies
Authors: Bolmer J. , Ledoux C. , Wiseman P. , De Cia A. , Selsing J. , Schady P. , Greiner J. , Savaglio S. , Burgess J. M. , D’Elia V. , Fynbo J. P. U. , Goldoni P. , Hartmann D. H. , Heintz K. E. , Jakobsson P. , Japelj J. , Kaper L. , Tanvir N. R. , Vreeswijk P. M. , Zafar T. 
Published: January 2019

Context. Damped Lyman-α (DLA) absorption-line systems at the redshifts of gamma-ray burst (GRB) afterglows offer a unique way to probe the physical conditions within star-forming galaxies in the early Universe.
Aims. Here we built up a large sample of 22 GRBs at redshifts z > 2 observed with VLT/X-shooter in order to determine the abundances of hydrogen, metals, dust, and molecular species. This allows us to study the metallicity and dust depletion effects in the neutral interstellar medium at high redshift and to answer the question of whether (and why) there might be a lack of H2 in GRB-DLAs.
Methods. We developed new methods based on the Bayesian inference package, PyMC, to FIT absorption lines and measure the column densities of different metal species as well as atomic and molecular hydrogen. The derived relative abundances are used to FIT dust depletion sequences and determine the dust-to-metals ratio and the host-galaxy intrinsic visual extinction. Additionally, we searched for the absorption signatures of vibrationally-excited H2 and carbon monoxide.
Results. We find that there is no lack of H2-bearing GRB-DLAs. We detect absorption lines from molecular hydrogen in 6 out of 22 GRB afterglow spectra, with molecular fractions ranging between f ≃ 5 × 10−5 and f ≃ 0.04, and claim tentative detections in three additional cases. For the remainder of the sample, we measure, depending on S/N, spectral coverage and instrumental resolution, more or less stringent upper limits. The GRB-DLAs in our sample have on average low metallicities, [X/H]¯ ≈ −1.3, comparable to the population of extremely-strong QSO-DLAs (log N(H I) > 21.5). Furthermore, H2-bearing GRB-DLAs are found to be associated with significant dust extinction, AV > 0.1 mag, and dust-to-metals ratios DTM > 0.4, confirming the importance of dust grains for the production of molecules. All these systems exhibit neutral hydrogen column densities log N(H I) > 21.7. The overall fraction of H2 detections in GRB-DLAs is ≥ 27% (41% including tentative detections), which is three to four times larger than in the general QSO-DLA population. For 2 < z < 4, and considering column densities log N(H I) > 21.7, the H2 detection fraction is 60–80% in GRB-DLAs and in extremely strong QSO-DLAs. This is likely due to the fact that both GRB- and QSO-DLAs with high neutral hydrogen column densities are probed by sight-lines with small impact parameters, indicating that the absorbing gas is associated with the inner regions of the absorbing galaxy, where the gas pressure is higher and the conversion of H I to H2 takes place. In the case of GRB hosts, this diffuse molecular gas is located at distances ≳ 500 pc from the GRB and hence is unrelated to the star-forming region where the event occurred.
The effect of laterite stone as filler on marshall stability hot mix asphalt AC-WC
Authors: Istiar  , Adi Tri Joko Wahyu , Sutikno  , Rahmat  , Kencanawati Martheana , Siara Ilham 
Published: January 2019

The highway is the main transportation infrastructure in Indonesia. Most of the highway pavement construction in Indonesia is flexible pavement. The filler commonly used in hot mixture asphalt is Portland Cement. Along with the issue of sustainable development and utilization of local materials, fillers are often replaced with cheaper and easily available materials. One material that can be used as a filler, cheaper and easily available is Laterite.
The experiment was proposed to find out whether laterite could be used as filler material on Asphalt Concrete Wearing Course (AC-WC). The method and technical specification of experiment referred to Asphalt Pavement Specification, that published by Public Work Ministry of Indonesia. The experiment had another objective. The experiment would be examine whether laterite percentage variation on filler material that mixed with Portland Cement, would effect on Marshall Stability value. The filler material was a mixture of laterite and Portland Cement, which the proportion of each were 0:100, 50:50, and 100:0. Each proportion of filler material compacted with 75 and 400 blows. There were 3 samples of each combination of the proportions of the filler material. The total number of specimens were 18. Furthermore, the Marshall stability value of each specimen would be tested using ANOVA test. And ANOVA test used Software Minitab 16.
The experiment result showed, Marshall Stability was greater than 800 kilograms as asphalt concrete wearing course (AC-WC) specification requirement. Analysis of Variance (ANOVA) test results using Minitab 16 software showed no difference in Marshall stability value on all specimens. Because, P-value of Laterite and compaction combination were less than 0.05.
Palliative Care for Neurologically Injured Patients: Why and How?
Authors: Bindu Barkha , Rath Girija P. 
Published: January 2019

AbstractThe role of palliative care in patients with cancer is widely acknowledged and practiced. Though its role in chronic, progressive, and incurable neurological conditions is being recognized now, it is not widely practiced. Lack of awareness and training are important factors contributing to this. Neurological patients differ from oncological patients with respect to their symptoms, fluctuating disease course, varied prognoses, and difficulty in identifying end-of-life stage. Knowledge of different neurological conditions is important to practice neuropalliative care appropriately. Growth of neuropalliative care services must begin with the neurologist at the center of the multidisciplinary team. Neurologists need to be trained in communication skills and advance care planning, and must be aware of end-of-life care, do-not-resuscitate policies, and withdrawal of life support measures. This article elaborates on these aspects of neuropalliative care and discusses its role in various neurological conditions.
Anesthetic Challenges of a Child with Sturge–Weber Syndrome for Epilepsy Surgery: A Case Report
Authors: Kurian Roshan , Lionel Karen R. , Mariappan Ramamani 
Published: January 2019

AbstractSturge–Weber syndrome is a rare congenital disease, also called encephalotrigeminal angiomatosis, caused by persistence of transitory primordial arteriovenous connections of the fetal intracranial vasculature. It is characterized by vascular malformations with capillary venous angiomas that involve the face, choroid of the eye, and leptomeninges. The main clinical features of this syndrome are port-wine stains, glaucoma, convulsions, and angiomas of the airway. Anesthesia management is directed toward anticipating a difficult airway, avoiding trauma to the hemangioma during airway manipulation, preventing the rise in the intracranial and intraocular pressures, anticipating and managing massive blood loss and the complications associated with massive blood transfusion, and avoiding factors that might trigger a seizure such as hypoxia, hypercarbia, hypotension, hypoglycemia, and hyperthermia.
Trazodone: A New Antiepileptic Drug for Dravet Syndrome?
Authors: Azevedo Kauppila Linda , Amorim Isabel , Bentes Carla , Peralta Ana Rita 
Published: January 2019

AbstractDravet syndrome (DS) is associated with severely refractory seizures. Recent studies suggest possible antiepileptic effects of serotonergic drugs. We report the case of a 25-year-old woman with DS-related epilepsy (SCN1A mutation), with daily seizures since childhood, associated with developmental delay. Several antiepileptic drug regimens were tested, without clear benefit. Over the years, she maintained a pattern of diurnal and nocturnal seizures, with a nocturnal predominance averaging two tonic–clonic seizures per night, with periods of seizure clusters. On routine electroencephalography (EEG), frequent, subtle myoclonic seizures during sleep were detected. A seizure-free period or significant reduction in seizure frequency was never attained. Trazodone was started due to insomnia. This led to a remarkable as well as long-standing clinical and neurophysiological improvement: less than one reported tonic–clonic seizure per month during the next 18 months, reduction in interictal epileptiform activity (170/h vs. 30/h of sleep), myoclonic seizures (90/h vs. 0.7/h of sleep), and tonic–clonic seizures (2/night to 0) on video-EEG. Serotonergic pathway modulation effects on DS-related epilepsy were observed in animal studies, in addition to small case series using lorcaserin and fenfluramine. To the best of our knowledge, no clinical data exist showing that trazodone may be an efficacious agent in patients with DS. Despite limitation of an isolated case with possible chance factors, our data, given the striking effect, provide this clinical evidence for the first time, and may have important clinical implications in patients with DS, reinforcing the need for further research on this subject.