bluuebunny/crossref_metadata_2025_split huggingface dataset:
A PROSPECTIVE STUDY ON DRUG UTILIZATION IN OBSTETRIC PROCEDURES WITH EMPHASIS ON ANTIBIOTIC USAGE AT A TERTIARY CARE HOSPITAL
Authors: Sachdeva Shikha , Chaudhary Aarti , Nain Parminder , Santpur Unmesh 
Published: September 2019

Background: Antibiotics are largely prescribed drugs in all major surgical procedures due to high prevalence of infections that has been increase in expenditure and increases antibacterial resistance. Drug utilization studies help to identify and overcome the misuse of antibacterial in prescribing pattern. Hence, the aim of this study was to evaluate the antibiotics utilization patterns in obstetric procedures.
Methods: It is a prospective observational study carried out in department of obstetrics and gynecology, of a multi-specialty teaching hospital (Haryana) after obtaining permission from the IEC. The prescriptions were assessed for patient’s demographic data, antimicrobial preference, dose, duration, and route of administration. Categorization of drugs according to Food and Drug Administration (FDA), and rationality score as per the World Health Organization (WHO).
Results: During six month study period 120 patients were included into study. The mean age of women undergoing C-section procedure was 27.79±2.78 years. The maximum (90.83%) length of hospital stay was 2 week by women under C-section procedure. The single antibiotic therapy (ceftriaxone - 53.33%) was the most commonly prescribed antibiotic as prophylaxis but in post- operative prescription orders, triple antibiotic combination therapy (ceftriaxone, metronidazole with gentamycin) was maximum (62.50%) prescribed antibiotic. Parenteral route (96.09% in pre-operative and 59.40% in post-operative) was most common route for antibiotic administration. Out of 2216 drugs, branded drugs were 1893 (85.42%) and generic drugs were 323 (14.58%).
Conclusion: The present study facilitates the rational use of ceftriaxone as prophylaxis in C-section and triple antibiotic combination therapy as post-operative by the gynaecologists. These antibiotics are most effective without any adverse effect on mother and fetus when use in recommended dose and frequency during obstetric procedures.
Keywords: Antibiotics, Caesarean section delivery, Drug utilization study
Microbiological substantiation of application of phytopreparations in treatment of inflammatory periodontal diseases
Authors: Abdurakhmanova S. A. , Runova G. S. , Podporin M. S. , Tsareva E. V. , Ippolitov E. V. , Tsarev V. N. 
Published: September 2019

Relevance:Inﬂammatory-destructive periodontal diseases are the most complicated and became the main cause of tooth loss in adult population. Herbal medicines have a variety of pharmacological properties, so the development and introduction of new forms for the treatment of inﬂammatory periodontal diseases is an urgent task today.Purpose– experimental evaluation of eﬀectiveness of the use of herbal medicines “Tonzinal” and “CM-1” in relation to the priority periodontal pathogenes.Materials and methods:in experimental studies, the basis for the experiment was the system for the cultivation of microorganisms in real time – the Revers-Spinner RTS-1 bioreactor. With the priority strains of periodontitis pathogens, the study of the growth dynamics of the culture was carried out in several parallels.Results:herbal medicines “CM-1” and “Tonsinal” has a multilateral therapeutic eﬀect, exerting a diverse inﬂuence on the key stages of development of such bacterial populations as Aggregatibacter actinomycetemcomitans, Streptococcus constellatus, Candida albicans.Conclusion:tan integrated approach in the treatment of patients with inﬂammatory periodontal diseases is promising and will contribute to a more prolonged remission and increase the eﬀectiveness of treatment.
Study of the distribution of internal stresses in prototype dentures supported by isoelastic dental implants and teeth
Authors: Dubova L. V. , Zolkina Yu. S. , Tagiltsev D. I. , Majidova E. R. 
Published: September 2019

Relevance: the aim of the research was to optimize the choice of material for fabrication of temporary dentures on isoelastic implants by ﬁnite element method.Materials and methods: four models were constructed of supporting element (basal PEEK implant, crestal PEEK implant and natural tooth in diﬀerent combination) and in prototype dentures from three diﬀerent materials. Areas of the maximum voltage in constructions have been revealed and possible loads have been calculated by ﬁnal element method.Results: the areas of maximum stress occur in the intraosseous part of implants in all studued cases.Conclusions: analysis of the data shows that the stresses in crowns is practically independent of the properties of the studied temporary bridges materials. Models 1 and 3 were the strongest. Model 4 was less strong.
Evaluation of the effectiveness of the main systemic antibiotics at the first stage of treatment of generalized aggressive periodontitis
Authors: Zakirov T. V. , Voroshilina E. S. , Brusnitsyna E. V. , Ioshchenko E. S. , Ozhgikhina N. V. 
Published: September 2019

Relevance: the aims of the study was to compare the eﬀectiveness of the use of various systemic antibiotics in patients with aggressive generalized periodontitis. A comparative study of systemic antibiotic therapy using modern molecular biological methods is important in modern periodontology.Materials and methods: a prospective, randomized, controlled study of 112 patients with generalized aggressive periodontitis before and after using systemic antibiotics with real-time PCR (GE/ml) of major periodontal pathogens. The median was chosen as a quantitative measure of central tendency. Upper and lower quartiles were used for interval estimation.Results: moxiﬂoxacin is most eﬀective against Porphyromonas gingivalis (median 102,1 GE/ml) and Tannerella forsythensis (median 103,7 GE/ml). Also eﬀective and reliably suppressed Porphyromonas gingivalis and Treponema denticola when lincomycin was used (medians 103,2, 102,7 GE/ml).Conclusion: the most eﬀective systemic antibiotics are moxiﬂoxacin and lincomycin, which signiﬁcantly reduced the number of Porphyromonas gingivalis, Tannerella forsythensis, and Treponema denticola in periodontal pockets.
Oral application of probiotics in the treatment of peri-implant mucositis
Authors: Ahmedbeyli C. R. 
Published: September 2019

Relevance: to evaluate the clinical eﬀectiveness of probiotic as an adjunct to professionally administered plaque removal (PAPR) in the treatment of peri-implant mucositis.Materials and methods: 42 patients with at least 2 implants with peri-implant mucositis and probing depth (PD) of 3-4 mm were selected and randomly divided into two groups. Test group received PAPR plus probiotic powder (Enteﬂavin® 4 g), whereas control group received PAPR only. Plaque index (PI), Gingival Index (GI), Bleeding on Probing (BoP), PD were measured at baseline and at days 21, 90, 180 and 360 after treatment.Results: TEST and control groups involved 21 patients with 61 implants and 21 patients with 59 implants, respectively. All clinical parameters were improved in both groups. Inter-group diﬀerences for PI, GI, BoP & PD were found to be statistically signiﬁcant at all time periods after the treatment in favor of test group (p < 0.05).Conclusion: PAPR alone or in combination with probiotic powder revealed clinical improvements in peri-implant mucositis patients. Better results were obtained with the adjunctive administration of probiotic. Probiotic therapy may be useful for the prevention and treatment of peri-implant mucositis.
Prophylaxis of inflammatory complications after an immediate dental implant surgery
Authors: Lepilin A. V. , Zakharova N. B. , Shalina M. Y. , Fishchev S. B. , Sevastyanov A. V. 
Published: September 2019

Relevance: among the directions of modern medicine dental implantology is currently experiencing rapid development. To predict the long-term positive result of surgical treatment, it is important to study the content of Pro- and anti-inﬂammatory cytokines (IL-8, MCP-1, RAIL, TNF) in the gingival ﬂuid and the validity of the use of immunomodulatory drugs after the installation of dental implants.Purpose – studying the features of changes in the immunoregulatory processes of the mouth cavity when using Imudon medication after dental implantation operation directly into the hole of the removed tooth.Materials and methods: materials, received during the examination of 83 patients, were used for work (42 menand 41 women), with partial secondary adentia, ages 20 to 50, who were treated in dental clinics of “Medstom”, “Masterdent”, and “Tari” (Saratov city).Results: received changes of pro inﬂammatory and anti-inﬂammatory levels of cytokines of the gingival sulcus in each examined group, with or without the use of Imudon medication, after implant installation, give the base to believe that after the operation in tissues, surrounding implants, form local changes of immunoregulatory processes.Conclusion: the possibility of early postoperative complications after dental implantation directly into the hole of the removed tooth decreases when prescribing Imudon medication in the ﬁrst 10 days of the postoperative period.
Evaluation of efficiency of complex treatment of patients with generalized chronic parodontitis and bruxism
Authors: Khaybullina R. R. , Gerasimova L. P. , Kabirova M. F. , Rakhmatullina R. Z. , Tkachenko E. D. , Galetti K. 
Published: September 2019

Relevance: the purpose of this work was to study the eﬀectiveness of proposed treatment and rehabilitation complex for patients with generalized chronic periodontitis and bruxism.Materials and methods: we examined 73 patients aged 30 to 45 years diagnosed with generalized chronic periodontitis of moderate severity and bruxism. Control group included 15 healthy individuals of the same age for clarify normal functional parameters. Clinical, Doppler ﬂowmetry and electromyographic methods were used for evaluation of the eﬀectiveness of proposed treatment and rehabilitation complex.Results: the course of treatment resulted in the increase in blood ﬂow perfusion volume by 37.7% (p < 0.05), of blood ﬂow perfusion rate by 58.2% (p<0.05) from baseline values. At the same time, the decrease in bioelectric activity of temporal muscle at rest by 51.82% (p >< 0.05), at voluntary contraction – by 40.4% (p<0.05), the decrease in bioelectric activity of masseter muscle at rest – by 47.4% (p><0.05), at voluntary contraction - by 35.12% (p >< 0.05) from values before treatment, were observed.Conclusion: data obtained on the basis of electromyography and laser Doppler ﬂowmetry showed that developed treatment and rehabilitation complex is an eﬀective method for correcting the microcirculation in periodontal vessels and the functional activity of the muscles of maxillofacial area.
The role of odontogenic infection role as a medical justification of planning the individual prevention programs in childbearing age women
Authors: Ulitovskiy S. B. , Kalinina O. V. , Spiridonova A. A. , Domorad A. A. 
Published: September 2019

Relevance:odontogenic infection plays an important role in the development of pregnancy complications, often causing premature birth of the child, as well as limiting its growth and development. According to studies Figueiredo C., Rosalem C., Cantanhede A. found that during pregnancy, women’s organs undergo various physiological, neurological and hormonal changes that occur gradually. In the process of such a restructuring of the body changes the dental status, which determines the correction stages of individual oral hygiene. According to the study Trigolos N. N., Firsova I. V., Makedonova Y. A. and others determined that dental health improves dental status, eliminates the possibility of exacerbation of chronic odontogenic foci of infection, reduces the risk of fetal infection and development of prenatal and postnatal complications, as well as a positive eﬀect on antenatal prevention of dental diseases of the child.Materials and methods:a total of 216 pregnant women were examined and monitored for a month. To study the hygienic status of women during pregnancy with the pathology of hard tissues of teeth, the hygienic index of green-Vermillion was used. Assessment of the acid-base state of the oral ﬂuid was carried out using the pH meter of the company “Hanna” with a replaceable pH electrode HI 1270. Antimicrobial activity of the hygiene of the mouth was studied with the use of diﬀerent means of oral hygiene in the process of carrying out hygienic measures to identify maximum eﬃciency in the selection of funds and the development of “personal hygiene prevention programme”.Results:the assessment showed an increase in the cleansing eﬀect for the entire period of the study in group 1 from 16.90 ± 3.53% to 49.77 ± 5.62%, in group 2 – from 28.19 ± 3.85% to 64.21 ± 6.32%, in contrast to the control – from 16.14 ± 3.21% to 35.87 ± 5.07%. Indicators of changes in acid-base eﬃciency of oral ﬂuid were in the 1st group 2.50 ± 0.20, in the 2nd group - 3.21 ± 0.20, and in the 3rd group was 2.38 ± 0.20.Conclusion:during pregnancy, it is necessary to choose the right hygiene products to ensure oral health and maintain odontogenic infectious status, which eliminates the risk of preterm birth, which threatens a pregnant woman. The importance of odontogenic infection and ways of prevention in women of childbearing age is determined by the development of measures to strengthen dental health and plays a leading role in the planning of individual programs for the prevention of major dental diseases in women of childbearing age.
Dynamics of indicators of reparative regeneration of the oral mucosa in patients with lichen planus
Authors: Firsova I. V. , Poroiskiy S. V. , Makedonova Yu. A. , Fedotova Yu. M. 
Published: September 2019

Relevance: red lichen planus refers to a long, protracted disease with a chronic course. There are a lot of root causes, it is quite diﬃcult to diﬀerentiate them. Therefore, pharmacotherapy of this pathology is reduced to the appointment of local drugs that have only symptomatic eﬀects that help accelerate the healing of the oral mucosa.Purpose – to study reparative regeneration based on the analysis of clinical and cytological examination on the background of the appointment of various methods of pharmacotherapy.Materials and methods: all patients were divided into two groups using simple randomization: in patients of the ﬁrst group, betamethasone B was used to treat erosive-ulcerative lesions, which were delivered to the lesion using Tisol, which has conductive transcutaneous activity, using the sandwich technique. The second group of patients used the drug delivery system in the form of a ﬁlm, which ﬁxed betamethasone B in the lesion area.Results: were evaluated before treatment, on day 7 and 14. The area and intensity of healing of the oral mucosa were determined, a qualitative and quantitative analysis of cytograms was carried out, which characterizes the dynamics of reparative regeneration of erosions and ulcers.Conclusion: based on the obtained clinical and laboratory data, it can be concluded that it is advisable to include betamethasone applications in the pharmacotherapy of patients with erosive and ulcerative forms of lichen planus. However, preference should be given to the method of layer-by-layer application of betamethasone B in combination with Tezol.
Hygienic assessment of the oral cavity in individuals with excess body mass index during orthopedic rehabilitation with removable dentures
Authors: Chesnokov V. A. , Chesnokova M. G. , Nesterova K. I. , Musienko A. I. 
Published: September 2019

Relevance: the search for ways to improve the eﬃciency of dental orthopedic rehabilitation of patients with dentition defects is relevant. Most people with overweight and obesity over 45 years old with a high incidence of pathology in the form of partial absence of teeth. Reducing the eﬀectiveness of chewing, taking highly carbohydrate foods contribute to an increase in the growth of plaque, the intensity of the carious process and the deterioration of hygienic indicators of the mouth.Purpose – to assess the hygienic condition of the oral cavity in patients with an excess of body mass index after orthopedic treatment with removable prostheses.Materials and methods: the survey was conducted to 57 individuals with excess body mass index (BMI): overweight and obesity at various times after the manufacture of partial removable laminar dentures after 1 month, 3 and 6 months after prosthetics. The dental formula, dentition classiﬁcation in Kennedy’s modiﬁcation and mucosa according to Supple, the presence of periodontal diseases, dental indexes were determined by the simpliﬁed hygiene index of the oral cavity ОНJ-S (Oral Hygiene Index Simple) and the gingivitis index GI (Gingivitis Index).Results: When using removable dentures, indicators of oral hygiene indices sharply deteriorated. After the ﬁrst month of wearing prostheses, the ONJ-S Green index increased by one third, after 3 months and 6 months, it worsened over the period of observation of patients. The Silnes–Low Index increased 1.5 times after a month of wearing a prosthesis, after 3 months – almost 2 times, after 6 months – 3.7 times, which corresponded to moderate gingivitis.Conclusion: studies have shown that overweight, obese people using removable dentures after prosthetics showed a deterioration in the index indicators – OHJ-S and Silnes–Low in the dynamics during the observation period for patients.
Correction of antioxidant protection of the oral mucosa in chronic pancreatitis
Authors: Lavrovskaya Ya. A. , Romanenko I. G. , Lavrovskaya O. M. 
Published: September 2019

Relevance:inﬂammatory processes in the oral mucosa are often found in diseases of the gastrointestinal tract, which is explained by the common functions and unity of all parts of the digestive system.Purpose– to study the eﬀect of the studied drugs on the state of antioxidant-prooxidant systems of the oral mucosa in patients with chronic pancreatitis.Materials and methods:we examined 118 patients, of whom 62 were men (mean age 39.6 ± 16.4 years) and 56 women (mean age 40.3 ± 15.7 years); of these, 34 patients (control group) are practically healthy people without somatic pathology and 84 patients with chronic pancreatitis who were divided into two groups. The ﬁrst (main) group - 46 people who, in addition to the drug therapy prescribed by the gastroenterologist, were prescribed the drug “Multiﬂora” 1 tablet 1 time per day with meals for 30 days. Also, the patients of the main group, after each meal, rinsed their mouths with “Enoant” food concentrate at a dilution of 1: 5 and applied it inside with 1 tablespoon 2 times a day, diluted with water in a ratio of 1: 5. The second (comparison group) - 38 people who, in addition to treatment of chronic pancreatitis, were treated with the oral mucosa according to the generally accepted method - prescribed ﬂuconazole 150 mg 1 time a day, rinsing with 2% borax solution in glycerol after eating for 14 days. Unstimulated oral ﬂuid of the examined patients served as the material for the study. In all groups, the activity of the catalase enzyme was determined by the method of S.V. Girina (1999), the level of malonic dialdehyde (MDA activity by reaction with thiobarbiturate acid to form a trimethine complex) and antioxidant-prooxidant index of unstimulated oral ﬂuid by the method of А.P. Levitsky (2010). Laboratory research was carried out at the time of the initial examination before the start and on the 30th day of treatment.Results:in the comparison group after treatment, an increased concentration of malondialdehyde in the oral ﬂuid, as well as reduced indicators of the API index and catalase activity conﬁrm the presence of inﬂammatory processes in the oral mucosa. The application of the proposed therapeutic complex to patients of the main group signiﬁcantly reduces the concentration of malondialdehyde in the oral ﬂuid, proving its anti-inﬂammatory eﬀect on the oral mucosa. An increase in the antioxidant-prooxidant index and an increase in catalase activity indicates an increase in the body’s defenses in patients of the main group.Conclusion:the use of the proposed therapeutic complex in patients with inﬂammatory diseases of the oral mucosa suﬀering from chronic pancreatitis contributes to the elimination of inﬂammatory and degenerative processes and the restoration of the normal level of protective systems in the oral mucosa.
Intravitreal Bevacizumab In Diabetic Macular Edema At RSUP Cipto Mangunkusumo in 2017
Authors: Victor Andi Arus , Masniah Masniah , Djatikusumo Ari , Elvioza Elvioza , Adriono Gitalisa Andayani , Yudantha Anggun Rama , Hutapea Mario Marbungaran 
Published: September 2019

Introduction: Diabetic Macular Edema (DME) is a manifestation of diabetic retinopathy and is the most common cause of vision loss in diabetics. The incidence of DME has a tendency to increase, concomitant with the prevalence of diabetes globally by more than 50% from 2000 to 2030. This study aims to evaluate the proportion of central macular thickness (CMT) improvement and visual acuity in DME patients treated with intravitreal bevacizumab (IVB) injection.
Methods: This study is a retrospective descriptive study. The study was conducted in the Department of Ophthalmology at RSUP Cipto Mangunkusumo (RSCM) Jakarta. Data were obtained from the medical records of all diabetic retinopathy patients with macular edema who were treated with IVB at RSCM Kirana Vitreoretina Polyclinic on January – December 2017.
Results: Of the 44 subjects, improvement in best corrected visual acuity (BCVA) occurred in 24 (54.54%) subjects at the first-month evaluation and 19 (43.18%) subjects at the third-month evaluation. CMT decreased in 37 (84.41%) subjects at the first-month evaluation and 35 (81.81%) subjects at the third-month evaluation.
Conclusion: Visual acuity improvement and central macular thickness reduction 3 months after IVB injection. These results strengthen IVB injection to be an alternative to adjuvant therapy in DME.

Keywords: Diabetic Macular Edema, Intravitreal Bevacizumab Injection
Nucleus Drop or Intraocular Lens Drop Underwent Pars Plana Vitrectomy due to Complication of Cataract Surgery
Authors: Vivin Noviana Kurniasari , Djatikusumo Ari , Elvioza Elvioza , Andayani Gitalisa , Yudantha Anggun Rama , Hutapea Mario Marbungaran , Victor Andi Arus 
Published: September 2019

Abstract
Background: The incidence of nucleus drop or intraocular lens (IOL) drop as the complication of phacoemulsification increases due to the increased frequency of phacoemulsification. Pars plana vitrectomy (PPV) followed by endofragmentation and secondary IOL implantation is the choice of procedure for management. This study aims to determine the frequency, outcomes, and complication of PPV in the case of nucleus drop or IOL drop in the Department of Ophthalmology, Fakultas Kedokteran Universitas Indonesia – Rumah Sakit Cipto Mangunkusumo (FKUI-RSCM)
Methods: This study is a retrospective descriptive study conducted in the Vitreoretinal Division of the Department of Ophthalmology, FKUI - RSCM. Research data was taken from the medical records of all nucleus drop or IOL drop patients underwent PPV in January 2017-December 2017.
Results: There were 19 cases studied. The incidence of nucleus drop occurred in phacoemulsification surgery techniques (94.7%) and ECCE techniques (5.3%). Vitrectomy surgery was performed ≤2 weeks in 31.6% and >2 weeks in 68.4% after the patient first arrived at the vitreoretinal clinic. Most pre-PPV visual acuity was 1/60-6/60 (47.1%). In the final follow-up, visual acuity improved from 6/45 to 6/6 occurred in 42.2% of cases. Complication after PPV and secondary IOL implantation include elevated IOP (10.5%), IOL decentration (5.3%), corneal decompensation (5.3%), macular edema (5.3%), and retinal detachment (5.3%).
Conclusion: Nucleus drop or IOL drop generally occurs in phacoemulsification cataract surgery techniques. Improved visual acuity was achieved after PPV and secondary IOL implantation at the end of the follow-up period. Most common post-PPV complication is elevated IOP.