bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular determinants of homo- and heteromeric interactions of Junctophilin-1 at triads in adult skeletal muscle fibers
Authors: Rossi Daniela , Scarcella Angela Maria , Liguori Enea , Lorenzini Stefania , Pierantozzi Enrico , Kutchukian Candice , Jacquemond Vincent , Messa Mirko , De Camilli Pietro , Sorrentino Vincenzo 
Published: July 2019

SignificanceTriads are specialized stable membrane contact sites present in skeletal muscles fibers, where 2 junctophilin isoforms (JPH1 and JPH2) tether the sarcoplasmic reticulum to the transverse tubules (T-tubules), which are infoldings of the sarcolemma. Several muscle-specific proteins are localized at triads, where they participate in the excitation–contraction (e-c) coupling process, which consists of a series of functional events resulting in muscle fibers’ contraction in response to electrical stimulation. Many reports have shown that JPH1, in addition to mediating the assembly of triads, can also interact with several proteins of the e-c coupling machinery. We report here that JPH1 and JPH2 can form homo- and heterodimers and that the transmembrane domain promotes the localization of JPH1, likely via interactions with endogenous JPHs.
Harnessing the interface mechanics of hard films and soft substrates for 3D assembly by controlled buckling
Authors: Liu Yuan , Wang Xueju , Xu Yameng , Xue Zhaoguo , Zhang Yi , Ning Xin , Cheng Xu , Xue Yeguang , Lu Di , Zhang Qihui , Zhang Fan , Liu Jianxing , Guo Xiaogang , Hwang Keh-Chih , Huang Yonggang , Rogers John A. , Zhang Yihui 
Published: July 2019

Significance
The 3D micro and nanostructures in advanced materials serve as the basis for emerging classes of 3D microsystems that have unusual function and/or enhanced performance, with potential applications in biomedical devices, energy storage systems, and elsewhere. The results presented here establish a fundamental understanding of various aspects of interface mechanics associated with routes to such 3D systems that exploit concepts similar to those in pop-up books, thereby allowing the construction of general design diagrams. Findings also indicate that these principles in interface mechanics can provide the basis for 3D mesostructures with reconfigurable geometries of relevance to morphing microdevices, such as micromechanical resonators, antennas, and optical modulators.
Through-thickness microstructure and mechanical properties in stationary shoulder friction stir processed AA7075
Authors: Patel Vivek , Li Wenya , Liu Xichang , Wen Quan , Su Yu 
Published: July 2019

Stationary shoulder friction stir processing of high strength thick AA7075 aluminium alloy demonstrated tiny gradient in the microstructure refinement across the thickness, which was attributed to the less heat input and small temperature gradient by the stationary shoulder. Stationary shoulder produced a very smooth surface finish with a little amount of flash throughout the processing area. Probe-dominated stir zone (SZ) resulted in uniform grain refinement as well as hardness distribution across the SZ thickness. The ductility in SZ increased by 48% in comparison to the unprocessed material without costing tensile strength. This tensile behaviour trend maintained throughout the thickness in SZ. GRAPHICAL ABSTRACT
Different Characteristics and Heritabilities of Alcohol Use Disorder Classes: A Population-Based Swedish Study
Authors: Long E C , Ohlsson H , Sundquist J , Sundquist K , Kendler K S 
Published: July 2019

Abstract

Aims
The aims of the present study are to identify alcohol use disorder (AUD) classes among a population-based Swedish sample, determine if these classes differ by variables known to be associated with AUD and determine whether some AUD classes have stronger genetic influences than others.

Methods
A latent class analysis (LCA), based on types of registrations, was conducted on Swedish individuals with an AUD registration born between 1960 and 1990 (N = 184,770). These classes were then validated using demographics; patterns of comorbidity with drug abuse, psychiatric disorders and criminal behavior; and neighborhood-level factors, i.e. peer AUD and neighborhood deprivation. The degree of genetic and environmental influence was also investigated.

Results
The best-fit LCA had four classes: (a) outpatient/prescription, characterized by a mix of outpatient medical and prescription registrations, (b) low-frequency inpatient, characterized entirely by inpatient medical registrations, with the majority of individuals having one AUD registration, (c) high-frequency mixed, characterized by a mix of all four registration types, with the majority having four or more registrations and (d) crime, characterized almost entirely by criminal registrations. The highest heritability for both males and females was found for Class 3 (61% and 65%, respectively) and the lowest for Class 1 (20% for both), with shared environmental influences accounting for 10% or less of the variance in all Classes.

Conclusions
Using comprehensive, nationwide registry data, we showed evidence for four distinct, meaningful classes of AUD with varying degrees of heritability.
Off-target capture data, endosymbiont genes and morphology reveal a relict lineage that is sister to all other singing cicadas
Authors: Simon Chris , Gordon Eric R L , Moulds M S , Cole Jeffrey A , Haji Diler , Lemmon Alan R , Lemmon Emily Moriarty , Kortyna Michelle , Nazario Katherine , Wade Elizabeth J , Meister Russell C , Goemans Geert , Chiswell Stephen M , Pessacq Pablo , Veloso Claudio , McCutcheon John P , Łukasik Piotr 
Published: July 2019

AbstractPhylogenetic asymmetry is common throughout the tree of life and results from contrasting patterns of speciation and extinction in the paired descendant lineages of ancestral nodes. On the depauperate side of a node, we find extant ‘relict’ taxa that sit atop long, unbranched lineages. Here, we show that a tiny, pale green, inconspicuous and poorly known cicada in the genus Derotettix, endemic to degraded salt-plain habitats in arid regions of central Argentina, is a relict lineage that is sister to all other modern cicadas. Nuclear and mitochondrial phylogenies of cicadas inferred from probe-based genomic hybrid capture data of both target and non-target loci and a morphological cladogram support this hypothesis. We strengthen this conclusion with genomic data from one of the cicada nutritional bacterial endosymbionts, Sulcia, an ancient and obligate endosymbiont of the larger plant-sucking bugs (Auchenorrhyncha) and an important source of maternally inherited phylogenetic data. We establish Derotettiginae subfam. nov. as a new, monogeneric, fifth cicada subfamily, and compile existing and new data on the distribution, ecology and diet of Derotettix. Our consideration of the palaeoenvironmental literature and host-plant phylogenetics allows us to predict what might have led to the relict status of Derotettix over 100 Myr of habitat change in South America.
Circulating human papillomavirus DNA detection in Barrett's dysplasia and esophageal adenocarcinoma
Authors: Parameshwaran K , Sharma P , Rajendra S , Stelzer-Braid S , Xuan W , Rawlinson W D 
Published: July 2019

SUMMARY
There is evidence to suggest that human papillomaviruses (HPV) are associated with Barrett's dysplasia and esophageal adenocarcinoma. In other HPV-linked cancers such as cervical and oropharyngeal cancer, circulating HPV DNA is a potential biomarker to assist in tumor diagnosis and management. This study aimed to determine whether circulating HPV DNA was detectable in patients with Barrett's dysplasia and esophageal adenocarcinoma, and if so, whether there is any correlation with esophageal tissue HPV status. Plasma from 138 patients representing esophageal adenocarcinoma (N = 41), Barrett's dysplasia (N = 48) and hospital controls (N = 49) were analyzed for the presence of circulating HPV DNA using droplet-digital PCR targeting the E7 gene of HPV types 16 and 18. Circulating HPV DNA was detected in 11/138 (8.0%) study subjects including 1/49 (2.0%) hospital controls, 4/48 (8.3%) Barrett's dysplasia patients, and 6/41 (14.6%) esophageal adenocarcinoma patients. Detection of circulating HPV DNA was higher in patients with HPV-positive esophageal tissue (6/35, 17.1%) compared to those with HPV-negative specimens (5/103; 4.9%) (OR = 4.06; 95% CI 1.15–14.25; P = 0.020). The highest rates of detection occurred in esophageal adenocarcinoma patients, particularly those with invasive tumors that had breached the esophageal submucosa, had regional lymph node involvement or metastatic disease. Circulating HPV DNA was detectable in a subset of Barrett's dysplasia and esophageal adenocarcinoma patients. Detection was associated with tissue HPV positivity and possibly disease severity.
A hydrocarbon-contaminated aquifer reveals a Piggyback-the-Persistent viral strategy
Authors: Paterson James S , Smith Renee J , McKerral Jody C , Dann Lisa M , Launer Elise , Goonan Peter , Kleinig Tavis , Fuhrman Jed A , Mitchell James G 
Published: July 2019

ABSTRACTSubsurface environments hold the largest reservoir of microbes in the biosphere. They play essential roles in transforming nutrients, degrading contaminants and recycling organic matter. Here, we propose a previously unrecognised fundamental microbial process that influences aquifer bioremediation dynamics and that applies to all microbial communities. In contrast to previous models, our proposed Piggyback-the-Persistent (PtP) mechanism occurs when viruses become more dominated by those exhibiting temperate rather than lytic lifestyles driven by persistent chemicals (in our case chlorinated-hydrocarbon pollutants) that provide long-term carbon sources and that refocus the aquifer carbon cycle, thus altering the microbial community. In this ultra-oligotrophic system, the virus:microbial ratio (VMR) ranges from below the detection limit of 0.0001 to 0.6, well below the common aquatic range of 3–10. Shortest-average-path network analysis revealed VMR and trichlorethene (TCE) as nodes through which ecosystem information and biomass most efficiently pass. Novel network rearrangement revealed a hierarchy of Kill-the-Winner (KtW), Piggyback-the-Winner (PtW) and PtP nodes. We propose that KtW, PtW and PtP occur simultaneously as competing strategies, with their relative importance depending on conditions at a particular time and location with unusual nutrient sources, such as TCE, appearing to contribute to a shift in this balance between viral mechanisms.
Comparison of malachite green adsorption by two yeast strains using Raman microspectroscopy
Authors: Liu Jinghua , Zha Dongchen , Chen Xinyi , Wang Yin , Wang Zihang , Li Zhengpeng 
Published: July 2019

ABSTRACT
Malachite green (MG), as a triarylmethane compound, poses a health hazard and causes considerable environmental concern. In this work, batch biosorption experiments were conducted under different operational conditions such as pH, contact time and adsorption dose to assess the optimal parameters of MG dye removal by yeast biomass from aqueous solutions. Then, the conventional biochemical assay was used to evaluate MG removal efficiency (75.18 and 95.85%) by Saccharomyces cerevisiae and Candida utilis. In addition, Fourier-transform infrared spectroscopy in combination with Raman microspectroscopy was employed to scrutinize the differences of dye removal between two types of yeast strains. This study demonstrates that Raman microspectroscopy may serve as a useful and powerful tool to quantitatively measure the content of MG dye on yeast cell surfaces in situ, and even offer an alternative new technique to seek potentially proper adsorbents for the removal of toxic dyes from industrial effluents.
Salience and Skewness Preferences
Authors: Dertwinkel-Kalt Markus , Köster Mats 
Published: July 2019

Abstract
Whether people seek or avoid risks on gambling, insurance, asset, or labor markets crucially depends on the skewness of the underlying probability distribution. In fact, people typically seek positively skewed risks and avoid negatively skewed risks. We show that salience theory of choice under risk can explain this preference for positive skewness, because unlikely, but outstanding payoffs attract attention. In contrast to alternative models, however, salience theory predicts that choices under risk not only depend on the absolute skewness of the available options, but also on how skewed these options appear to be relative to each other. We exploit this fact to derive novel, experimentally testable predictions that are unique to the salience model and that we find support for in two laboratory experiments. We thereby argue that skewness preferences—typically attributed to cumulative prospect theory—are more naturally accommodated by salience theory.
Alive After Academia
Authors: Zeiger Spencer J. 
Published: July 2019

Abstract
Social work educators have lived through unique experiences and possess knowledge of lifespan development, which may enable them to navigate the vicissitudes of aging and envision a rich life beyond the traditional limits of a career. This book explores what becomes of these professionals after they depart from the academy and what trials, tribulations, and adventures await them. What can today’s social work educators learn from veterans who are either approaching or have transitioned to life after academia? Grounded in 39 in-depth interviews, study participants tell engaging and inspirational stories—stories that will benefit social work educators and academicians from other disciplines who are poised to embrace life beyond the academy and who wish to critically evaluate their life’s work. The term The Next Chapter is introduced as a positive alternative to the traditional moniker “retirement.” Fruits of The Next Chapter include post-academic freedom, new (and renewed) life appreciations, and an opportunity to integrate components of one’s life. This book provides a valuable guide that enables social work educators to determine the optimal time to depart from academia and advance to the next chapter of life.
Introduction
Authors: Bezzant Rhys S. 
Published: July 2019

Abstract
Taking up correspondence between Edwards’s closest associates, Samuel Hopkins and Joseph Bellamy, we begin our investigation of the concept of mentoring in Edwards’s ministry. This chapter highlights the challenges involved in writing on the mentoring of an historical figure, for example the difficulty of exploring a ministry, which is often private and without documentation, as well as the method adopted to capture the pastoral and theological insights that animate Edwards’s practice. Feminist historians have provided a lead in this kind of method. The content of the book is outlined as a case study in cultural engagement, and the potential readership among academics and pastor-theologians is acknowledged.
The Traditioned Self
Authors: Bezzant Rhys S. 
Published: July 2019

Abstract
Edwards did not invent the practice of mentoring. In the premodern world, identity was received rather than created, and mentoring served this traditional means of personal formation. This chapter investigates the significance of the cultivation of virtue for a flourishing life, and the ways in which discipline functioned as a strategy for virtue formation in the post-Reformation world. The examples of Richard Baxter and Cotton Mather are presented as significant landmarks in that story. Edwards’s own upbringing in New England, with its Puritan expectations of life and ministry, is unpacked as a way of understanding the innovation Edwards would ultimately pursue in a ministry of mentoring.
The Mimetic Way
Authors: Bezzant Rhys S. 
Published: July 2019

Abstract
Edwards’s chief theological justification for mentoring arises from the doctrine of the beatific vision, or the significance for our present life, ministry, and spirituality of meeting Christ face to face at the end of the age. Visual imagery is a constant feature of Edwards’s teaching, which is here combined with his approach to the image of God in human beings, the Christological nature of imitation, and the pressure points of modernity. The first things, near things, and last things are signposts to Edwards’s understanding of the power of mentoring in human experience. We see how integrative the mentoring project is for him, in as far as it obviates the fragmenting narrative of the Enlightenment. Edwards’s theological and cultural reflex is both to resist and appropriate modern categories of thought.
Coda
Authors: Bezzant Rhys S. 
Published: July 2019

Abstract
This brief coda positions Edwards’s insights into mentoring as valuable contributions to the pursuit of integrative learning in a postmodern and fragmented world. Given the value of the medium and message being mutually reinforcing, a Christian educational agenda should no less conform to this pedagogical assumption. This is supported theologically by appeal to Christ’s incarnation and to the expectation of meeting him face-to-face in the coming age, and calls us to resist pragmatic pressures which prize efficiency over embodiment. The long-term pursuit of wisdom, best acquired through direct encounter, personal negotiation, and contextually driven decision-making, becomes more pressing than ever in an age which encourages rage and unreflective reaction through social media.
Introduction
Authors: Raychaudhuri Anindya 
Published: July 2019

Abstract
This chapter provides a brief historical outline of the events of partition, and an introduction to the theoretical framework that underpins the book’s central themes. The historical context is read through the lens of the politics of memory and representation—in particular focusing on the ways in which state-endorsed narratives of history are used to reinforce contemporary domestic and foreign policy. The chapter begins to outline the ways in the narratives that are the focus of this book engage with and challenge such “official” views of partition. This introductory chapter also sets out the current scholarship of partition—concentrating on memory and oral history—and marks out the space in existing scholarship where this book sits.
“All trains stop there”
Authors: Raychaudhuri Anindya 
Published: July 2019

Abstract
This chapter focuses on what is probably the most popular icon of partition narratives—that of refugee trains being attacked and turned into “death trains.” There is hardly a single partition narrative in any genre that does not mention trains in some form or another. This chapter charts the ways in which train journeys have been represented in literature, cinema, and oral history testimonies in an attempt to explain the reason for this predominance. If we see partition as a violent re-inscribing of social hierarchies, then the icon of the “death train” becomes a space within which individual and collective agency can be expressed, as the dynamic between state and non-state forces is played out in this microcosm of the nation.
From Socialist Realism to the Prague Spring
Authors: Hagen Trever 
Published: July 2019

Abstract
Chapter 2 explores aesthetic models, forms, and materials of creative practices in Czechoslovakia from the 1940s to the 1960s. It centers on how people made available aesthetic resources: the practice of furnishing an ecology. I examine the historical conditions of artistic production of post–World War II Stalinism’s “socialist realism” to the Czechoslovak Prague Spring and its political direction of “socialism with a human face” beginning with Egon Bondy’s work. I focus particularly on his biography as a producer and early poetry works after the 1948 coup, emphasizing two styles he developed with Ivo Vodseďálek from 1950 and 1951: Total Realism (Totalní Realismus) and Poetry of Embarrassment (Trapná Poezie). These poetic styles and content served as a response to the perceived absurdity of post-1948 Stalinist culture felt by Bondy and Vodseďálek. By examining this body of work, I investigate what Total Realism and Poetry of Embarrassment afforded, solved, and transmitted. On the heels of Stalin’s death and Khrushchev’s secret speech in 1956, I continue onto the boom and popularity of rock ’n’ roll during the 1960s and the initial, inchoate formation of the Underground following the Prague Spring of 1968. I analyze people’s engagement with circulating cultural media during this period that contributed to a cosmopolitan music scene in Prague, detailing the proto-underground rock bands of the 1960s and the emergence of psychedelic music in Prague.
Creativity, Establishment, and the Self
Authors: Hagen Trever 
Published: July 2019

Abstract
This chapter outlines how acts of state oppression repressed environmental conditions that contradictorily enabled the expressive practice of “truth to self.” This repression heightened forms of collective awareness of an Underground “way of life” and points to how the politics of music-making is an emergent and embodied phenomenon. I trace how musicking came to be crafted within the Merry Ghetto, showing how practices (composing to lyrics, listening to records, playing with spirit, adapting poems as lyrics, writing and thinking about music) were linked to aesthetic phenomena (out-of-tune, rough and ragged sounds, sing-song recitation, heavy bass lines, screamed vocals, raw, unmusical sounds) that provided models, through contrast and comparison structures, for learning dispositions (how to feel and know “establishment,” “truth to self,” historical commitment, rejection) in the Merry Ghetto. This chapter considers some of the core building blocks of cultural ecologies by asking how music mediates knowledge production, commitment-making, and ontological security. I explore the “life sustaining” qualities of a habitat built through music that in fact have more to do with well-being, mental health, and protection than with protest and revolution. In short, it addresses music as a material of “cocooning,” as a form of protection.
Generating New Waves
Authors: Hagen Trever 
Published: July 2019

Abstract
This chapter engages the broader parallel non-official culture that emerged in Czechoslovak late socialism and moves the timeline forward to address some of the characteristics of the Merry Ghetto, and more generally non-official musicking, in the 1980s. Cases of musicking during the 1980s problematize “generation” by exposing it not necessarily in terms of only age gap but also in how new arenas of being and thinking were generated from cultural resources that were crafted in the 1970s. I explore the mechanisms of “generation” through convergence zones between non-official cultural ecologies by discussing a further core group of musicians and musicking practices during 1970s Czechoslovakia, the Alternatives.
Communities Making a Difference
Authors: Kral Michael J. 
Published: July 2019

Abstract
This chapter discusses how health and well-being have been delivered and managed in the Canadian Arctic, and how delivery and management have moved from the federal to territorial government. The chapter presents what two Inuit communities have done themselves for suicide prevention. Rather than employing evidence-based, Western approaches to suicide prevention in the Arctic that have not worked, when Inuit communities design and operate their own suicide prevention activities and programs, they are effective. Indigenous community control over health and mental health activities and programs has been central to their success. This is a form of collective agency and efficacy. In the primary community of focus, it was youth who designed and managed suicide prevention. These youth are examined in detail.