bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic tension‐type headache and coping strategies in adolescents: A qualitative interview study
Authors: Skogvold Lars , Magnussen Liv Heide 
Published: April 2019

AbstractObjectiveHeadache is the most common cause of chronic pain in children and adolescents and may influence on several of the life's arenas such as high absence from school and inability to maintain leisure time activities. Adolescents with chronic headache also report co‐morbidities such as anxiety, depression, insomnia, and reduced quality of life. This study aimed to explore which strategies adolescents use to cope with chronic tension‐type headache in everyday life.MethodsA qualitative design with semistructured individual interviews was used. A strategic sample of 17 adolescents aged 14–19 with tension‐type headache participated in the study. The interviews were audiotaped and transcribed verbatim. Transcripts were analysed using systematic text condensation.ResultsTo deal with the headache in everyday life, the adolescence expressed that it is important to have a good structure during the day, especially regarding regular meals and enough sleep. Sufficient rest and relaxation were also highlighted as crucial. Some of the adolescence had tried different therapies to help ease the pain but with varying effect. All of the adolescents had used or were using pain relievers, but they were ambivalent to the benefits. Low‐intensity physical activity was perceived as beneficial and gave increased overall well‐being. Such activity also gave release and distraction from the headache.ConclusionThe adolescents used both problem‐focused active strategies and emotion‐focused passive strategies to deal with their headache in daily life. Through exploration and awareness of the types of behaviour that worked and did not work, they had arrived at strategies that helped them cope with their headache and its consequences.
Pentapnictogen heterocyclic monoanions: Structure, stability, and aromaticity
Authors: Chen Jiatian , Yang Le , Li Ying , Hou Qinghua , Li Lanlan , Jin Peng 
Published: April 2019

AbstractInorganic planar ring‐shape molecules with 4n + 2 π electrons are always the focus of experimental synthesis and theoretical research due to their potential aromaticity and stability. In this work, the whole series of five‐membered heterocycle monoanions X
nY5‐n− (X, Y = group 15 elements; n = 1‐4) were thoroughly investigated by means of density functional theory calculations. They all have large formation energies and HOMO‐LUMO gap energies, suggesting the potential thermodynamic and kinetic stability. Their aromaticities are comparable to that of typical aromatic hydrocarbons. Their thermal stabilities were firmly established by the ab initio molecular dynamics simulations. As most of them are predicted for the first time, their various spectra were simulated for experimental characterization. Furthermore, we demonstrate that these five‐membered cyclic anions can be employed as η5‐ligand to construct novel all‐inorganic metallocenes, which may serve as the building blocks of low‐dimensional nanomaterials.
Cobalt‐Catalyzed Three‐Component Synthesis of Propargylamine Derivatives and Sonogashira Reaction: A Comparative Study between Co‐NPs and Co‐NHC@MWCNTs
Authors: Hajipour Abdol R. , Khorsandi Zahra , Mohammadi Bahareh 
Published: April 2019

AbstractComplex of cobalt N‐heterocyclic ligands supported on multi‐walled carbon nanotube (Co‐NHC@MWCNTs) and pure cobalt nanoparticles (Co‐NPs) were synthesized. Their catalytic activities for synthesis of propargylamine derivatives and Sonogashira reaction was explored and compared. All reactions resulted in moderate to excellent yields using these inexpensive and efficient catalysts in green media and mild reaction conditions. Our investigation displayed that the efficiency and reusability of the Co‐NHC@MWCNTs is superior to other (Co‐NPs).
1,1,1,4,4,4‐Hexafluorobut‐2‐yne (HFB) as a Versatile Dipolarophile for [3+2] Cycloaddition with 1,3‐Dipoles toward Azoles with Adjacent CF3 Groups
Authors: Yagupolskii Yurii L. , Pavlenko Natalia V. , Gerus Igor I. , Peng Sheng , Nappa Mario 
Published: April 2019

AbstractThis project involves the syntheses of novel pyrazoles, pyrazolines and isoxazoles with two CF3 groups via 1,3‐dipolar cycloaddition reaction of 1,1,1,4,4,4‐hexafluorobut‐2‐yne (HFB) with diazocompounds, azomethine imines and nitrile oxides, respectively. Conditions for these azoles preparation differ in catalyst‐free mild manners and are applicable to a wide range of substrates, while demonstraiting a high functional group tolerance with yields of target heterocycles from moderate to excellent. Indeed, pyrazolines bearing two adjacent CF3 groups are practically unknown up to date.
3D Bioprinting in Skeletal Muscle Tissue Engineering
Authors: Ostrovidov Serge , Salehi Sahar , Costantini Marco , Suthiwanich Kasinan , Ebrahimi Majid , Sadeghian Ramin Banan , Fujie Toshinori , Shi Xuetao , Cannata Stefano , Gargioli Cesare , Tamayol Ali , Dokmeci Mehmet Remzi , Orive Gorka , Swieszkowski Wojciech , Khademhosseini Ali 
Published: April 2019

AbstractSkeletal muscle tissue engineering (SMTE) aims at repairing defective skeletal muscles. Until now, numerous developments are made in SMTE; however, it is still challenging to recapitulate the complexity of muscles with current methods of fabrication. Here, after a brief description of the anatomy of skeletal muscle and a short state‐of‐the‐art on developments made in SMTE with “conventional methods,” the use of 3D bioprinting as a new tool for SMTE is in focus. The current bioprinting methods are discussed, and an overview of the bioink formulations and properties used in 3D bioprinting is provided. Finally, different advances made in SMTE by 3D bioprinting are highlighted, and future needs and a short perspective are provided.
Quantum Sensing in a Physiological‐Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers
Authors: Price Joshua C. , Levett Simon J. , Radu Valentin , Simpson David A. , Barcons Aina Mogas , Adams Christopher F. , Mather Melissa L. 
Published: April 2019

AbstractFluorescent nanodiamonds (fNDs) containing nitrogen vacancy (NV) centers are promising candidates for quantum sensing in biological environments. This work describes the fabrication and implementation of electrospun poly lactic‐co‐glycolic acid (PLGA) nanofibers embedded with fNDs for optical quantum sensing in an environment, which recapitulates the nanoscale architecture and topography of the cell niche. A protocol that produces uniformly dispersed fNDs within electrospun nanofibers is demonstrated and the resulting fibers are characterized using fluorescent microscopy and scanning electron microscopy (SEM). Optically detected magnetic resonance (ODMR) and longitudinal spin relaxometry results for fNDs and embedded fNDs are compared. A new approach for fast detection of time varying magnetic fields external to the fND embedded nanofibers is demonstrated. ODMR spectra are successfully acquired from a culture of live differentiated neural stem cells functioning as a connected neural network grown on fND embedded nanofibers. This work advances the current state of the art in quantum sensing by providing a versatile sensing platform that can be tailored to produce physiological‐like cell niches to replicate biologically relevant growth environments and fast measurement protocols for the detection of co‐ordinated endogenous signals from clinically relevant populations of electrically active neuronal circuits.
The impact of cultural appropriation on destination image, tourism, and hospitality
Authors: Gertner Rosane K. 
Published: April 2019

AbstractHarsh critics have relentless exposed myriad instances of misuse, exploitation, and misrepresentation of values, customs, rituals, and religious objects, for example, by different actors, such as designers and artists, and in myriad contexts, such as in art, entertainment, and tourism. Instead of being perceived as the appreciation or preservation of cultures, as claimed, they have been condemned as cultural appropriation. Occasionally, they are deemed offensive by members of the culture of origin. In the context of destination image, tourism, and hospitality, the matter can be even more problematic as many places are economically dependent on tourism and hospitality services. A growing number of critics believe place brands in general and tourist destinations in particular have exploited indigenous groups for the commercial purpose of entertaining visitors. This article represents a pioneer effort to build awareness among place marketing scholars and practitioners, particularly in the context of tourism, of the importance, implications, and risks of cultural appropriation to the future of destination image, reputation, attractiveness, and sustainability and advances suggestions for future research.
Treatment Patterns and Economic Burden by Lines of Therapy Among Patients with Advanced Hepatocellular Carcinoma Treated with Systemic Cancer Therapy
Authors: Bonafede Machaon M. , Korytowsky Beata , Singh Prianka , Cai Qian , Cappell Katherine , Jariwala-Parikh Krutika , Sill Bruce , Parikh Neehar D. 
Published: April 2019

Abstract
Purpose
This study examined clinical and economic outcomes among patients with advanced hepatocellular carcinoma (HCC) treated with systemic agents by line of therapy.

Methods
Adults with ≥ 2 medical claims for primary diagnosed HCC (from January 1, 2008, through September 30, 2015) and ≥ 1 claim for systemic HCC-related therapy were identified in the IBM MarketScan® Research Databases. Continuous enrollment was required 6 months before and 1 month after diagnosis. Patients were categorized into first- (1L) and second-line (2L) treatment cohorts; those receiving sorafenib as 1L were evaluated. Treatment patterns, healthcare resource utilization, costs, and survival during 1L and 2L therapy were measured. Survival was assessed for patients linked to the Social Security Administration Master Death File.

Results
1459 patients, 758 with death data, met the 1L cohort criteria; 163 patients, 87 with death data, later received 2L therapy. 77.1% had 1L sorafenib, alone or in combination. Median 1L treatment duration was 3.0 months; median survival time from start of 1L to death or censor was 6.8 months. There was no predominant 2L agent. Median 2L treatment duration was 3.0 months; median survival time from start of 2L was 9.3 months. Median total healthcare costs per patient per month were $13,297 for 1L (all), $13,471 for 1L (sorafenib), and $11,786 for 2L.

Conclusions
Findings confirm high 1-year mortality for advanced HCC, suggesting a high cost burden. While no 2L therapy was available during this analysis, recently approved 2L agents have the potential to improve survival after sorafenib failure or intolerance.
Stereotypes About Enterotype: The Old and New Ideas
Authors: Cheng Mingyue , Ning Kang 
Published: April 2019

Abstract
In 2011, the term “enterotype” first appeared to the general public in Nature, which refers to stratification of human gut microbiota. However, with more studies on enterotypes conducted nowadays, doubts about the existence and robustness of enterotypes have also emerged. Here we reviewed current opinions about enterotypes from both conceptual and analytical points of view. We firstly illustrated the definition of the enterotype and various factors influencing enterotypes, such as diet, administration of antibiotics, and age. Then we summarized lines of evidence that pose the concept against the enterotype, and described the current methods for enterotype analysis. Finally, we showed that the concept of enterotype has been extended to other ecological niches. Based on current studies on enterotypes, it has been clear that more studies with larger sample sizes are needed to characterize the enterotypes. Improved computational methods are also required to build sophisticated models, reflecting the dynamics and resilience of enterotypes.
Antibiotic Treatment Drives the Diversification of the Human Gut Resistome
Authors: Li Jun , Rettedal Elizabeth A. , van der Helm Eric , Ellabaan Mostafa , Panagiotou Gianni , Sommer Morten O.A. 
Published: April 2019

Abstract
Despite the documented antibiotic-induced disruption of the gut microbiota, the impact of antibiotic intake on strain-level dynamics, evolution of resistance genes, and factors influencing resistance dissemination potential remains poorly understood. To address this gap we analyzed public metagenomic datasets from 24 antibiotic treated subjects and controls, combined with an in-depth prospective functional study with two subjects investigating the bacterial community dynamics based on cultivation-dependent and independent methods. We observed that short-term antibiotic treatment shifted and diversified the resistome composition, increased the average copy number of antibiotic resistance genes, and altered the dominant strain genotypes in an individual-specific manner. More than 30% of the resistance genes underwent strong differentiation at the single nucleotide level during antibiotic treatment. We found that the increased potential for horizontal gene transfer, due to antibiotic administration, was ∼3-fold stronger in the differentiated resistance genes than the non-differentiated ones. This study highlights how antibiotic treatment has individualized impacts on the resistome and strain level composition, and drives the adaptive evolution of the gut microbiota.
Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment
Authors: Li Ning , Yang Junjie , Zhang Jiaming , Liang Cheng , Wang Ying , Chen Bin , Zhao Changying , Wang Jingwen , Zhang Guangye , Zhao Dongmei , Liu Yi , Zhang Lehai , Yang Jun , Li Guimei , Gai Zhongtao , Zhang Lei , Zhao Guoping 
Published: April 2019

Abstract
Variation of maternal gut microbiota may increase the risk of autism spectrum disorders (ASDs) in offspring. Animal studies have indicated that maternal gut microbiota is related to neurodevelopmental abnormalities in mouse offspring, while it is unclear whether there is a correlation between gut microbiota of ASD children and their mothers. We examined the relationships between gut microbiome profiles of ASD children and those of their mothers, and evaluated the clinical discriminatory power of discovered bacterial biomarkers. Gut microbiome was profiled and evaluated by 16S ribosomal RNA gene sequencing in stool samples of 59 mother–child pairs of ASD children and 30 matched mother–child pairs of healthy children. Significant differences were observed in the gut microbiome composition between ASD and healthy children in our Chinese cohort. Several unique bacterial biomarkers, such as Alcaligenaceae and Acinetobacter, were identified. Mothers of ASD children had more Proteobacteria, Alphaproteobacteria, Moraxellaceae, and Acinetobacter than mothers of healthy children. There was a clear correlation between gut microbiome profiles of children and their mothers; however, children with ASD still had unique bacterial biomarkers, such as Alcaligenaceae, Enterobacteriaceae, and Clostridium. Candidate biomarkers discovered in this study had remarkable discriminatory power. The identified patterns of mother–child gut microbiome profiles may be important for assessing risks during the early stage and planning of personalized treatment and prevention of ASD via microbiota modulation.
Integration of genomic and clinical data augments surveillance of healthcare-acquired infections
Authors: Ward Doyle V. , Hoss Andrew G. , Kolde Raivo , van Aggelen Helen C. , Loving Joshua , Smith Stephen A. , Mack Deborah A. , Kathirvel Raja , Halperin Jeffery A. , Buell Douglas J. , Wong Brian E. , Ashworth Judy L. , Fortunato-Habib Mary M. , Xu Liyi , Barton Bruce A. , Lazar Peter , Carmona Juan J. , Mathew Jomol , Salgo Ivan S. , Gross Brian D. , Ellison Richard T. 
Published: April 2019

AbstractBackground:Determining infectious cross-transmission events in healthcare settings involves manual surveillance of case clusters by infection control personnel, followed by strain typing of clinical/environmental isolates suspected in said clusters. Recent advances in genomic sequencing and cloud computing now allow for the rapid molecular typing of infecting isolates.Objective:To facilitate rapid recognition of transmission clusters, we aimed to assess infection control surveillance using whole-genome sequencing (WGS) of microbial pathogens to identify cross-transmission events for epidemiologic review.Methods:Clinical isolates ofStaphylococcus aureus,Enterococcus faecium,Pseudomonas aeruginosa, andKlebsiella pneumoniaewere obtained prospectively at an academic medical center, from September 1, 2016, to September 30, 2017. Isolate genomes were sequenced, followed by single-nucleotide variant analysis; a cloud-computing platform was used for whole-genome sequence analysis and cluster identification.Results:Most strains of the 4 studied pathogens were unrelated, and 34 potential transmission clusters were present. The characteristics of the potential clusters were complex and likely not identifiable by traditional surveillance alone. Notably, only 1 cluster had been suspected by routine manual surveillance.Conclusions:Our work supports the assertion that integration of genomic and clinical epidemiologic data can augment infection control surveillance for both the identification of cross-transmission events and the inclusion of missed and exclusion of misidentified outbreaks (ie, false alarms). The integration of clinical data is essential to prioritize suspect clusters for investigation, and for existing infections, a timely review of both the clinical and WGS results can hold promise to reduce HAIs. A richer understanding of cross-transmission events within healthcare settings will require the expansion of current surveillance approaches.
Surface groups, infinite generating sets, and stable commutator length
Authors: Margalit Dan , Putman Andrew 
Published: April 2019

AbstractWe give a new proof of a theorem of D. Calegari that says that the Cayley graph of a surface group with respect to any generating set lying in finitely many mapping class group orbits has infinite diameter. This applies, for instance, to the generating set consisting of all simple closed curves.
A Context-Appropriate Approach to Marine 14C Calibration: Δr and Bayesian Framework for the Nuvuk Cemetery, Point Barrow, Alaska
Authors: Krus Anthony M , Jensen Anne M , Hamilton W Derek , Sayle Kerry 
Published: April 2019

ABSTRACTThis study provides an assessment of the temporal changes in ΔR, which is the local deviation from the global surface water marine reservoir effect (MRE), in the Point Barrow area of the Alaskan Arctic, a coastal archaeological area that has experienced severe erosion accelerated by global warming. A total of 26 samples were submitted for radiocarbon (14C) dating from eight secure Thule (AD 1000–1750) archaeological contexts, and specifically from archaeological features with paired processed seal and caribou bones that had been frozenin situ. This new approach towards ΔR estimation provides a best-fit local correction for the14C dating of human populations by focusing on the marine mammal (seals) predominantly consumed by the Thule (Coltrain et al. 2016). The weighted-mean ΔR value on these pairs is 450 ± 84 yr, which is about 50 years less than the weighted-mean (506 ± 69 yr) for the Point Barrow area calculated through14C measurements from four known-age bivalves collected in AD 1913 (McNeely et al. 2006). The effects of using this new ΔR value for calibration was assessed through the Bayesian chronological modeling of 5414C measurements from samples of human skeletons interred in the Nuvuk cemetery at Point Barrow, the largest ancient cemetery in northwest Alaska and traditionally thought to date to the Thule and earlier Birnirk (AD 500–1000) periods.
Faces of the Self
Authors: Seth Vanita 
Published: April 2019

AbstractThis paper traces the centrality of the human face in the construction of modern individuality. It argues that the face of individuality no less than that of typology, is mired in and born of historical and political conditions that are subsequently disavowed in order that the individual (and the face she bears) is rendered a product of nature, an instantiation of the universal. Attempting to denaturalize and defamiliarize the authority invested in the face, this paper maps out three interrelated arguments: that the human face is historically produced; that its history is closely tethered to the production of modern subjectivity, and that its status as a purveyor of meaning relies upon the reiteration of preexisting norms through which it can be “read.” And yet, while this paper turns to the nineteenth century to trace the novel privileging of the face as an extension of selfhood, interwoven through this history is the figure of the “effaced” Muslim woman and the Muslim terrorist type.
UNDERSTANDING THE MINIMUM WAGE: POLITICAL ECONOMY AND LEGAL FORM
Authors: Adams Zoe 
Published: April 2019

AbstractThis article explores how the legal system has constructed, over time, the concept of the “wage”. Drawing on insights from classical political economy it contrasts a conception of the wage as the cost of social reproduction (a “social wage”), with the neoclassical notion of the wage as the price of a commodity (a “market wage”) that we see embedded in legal and political discourse today. Drawing on historical sources, it explores how these competing ideas of the wage have been reconstructed in juridical language in case law and legislation over time, exploring at the same time the impact of this process on the relationship between minimum wages and tax credits. This analysis is then used to shed light on the conception of the wage embedded in the National Minimum Wage Act 1998, providing a critical re-evaluation of the “National Living Wage” introduced in 2016.
TOWARDS A TAXONOMY FOR PUBLIC AND COMMON PROPERTY
Authors: Rodgers Christopher 
Published: April 2019

AbstractThis article argues that public property rights should be recognised as a separate category of property interest, different and distinct from private and common property interests and conferring distinctive rights and obligations on both “owners” and members of the public. It develops a taxonomy to differentiate private, public and common property rights. The article concludes that it is a mistake to think in terms of “private property”, “common property” or “public property”. The division and allocation of resource entitlements in land can result in private, common and public property rights subsisting over the same land simultaneously, in different combinations and at different times. The categorisation of property interests in land (as private, common or public) may also shift and change from time to time. The article considers the importance of distinguishing between private, common and public property interests for developing new strategies for environmental governance, and for implementing the effective protection of natural resources.