bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of lidocaine on subacute thyroiditis via restraining inflammatory factor expression and inhibiting pyroptosis pathway
Authors: Yang Xi , Yang Liu‐Xue , Wu Ji , Guo Man‐Li , Zhang Yong , Ma Shao‐Gang 
Published: April 2019

AbstractBackground: To explore the role of lidocaine on subacute thyroiditis (SAT) and the molecular mechanism.Methods: SAT models were constructed by infecting adenovirus to thyroid follicular epithelial cells. Cells were randomly divided into five groups: model group, low lidocaine, middle lidocaine, high lidocaine, and a control group. Thyroid secretion related factors TG and TPO, T3 and T4 were separately determined by reverse transcription‐polymerase chain reaction (RT‐PCR) and radioimmunoassay. Flow cytometry was used to determine thyroid follicular epithelial cell apoptosis situation. RT‐PCR and Western blot analysis were used to determine the expression of inflammatory cytokines and pyroptosis related factors interleukin (IL)‐1α, IL‐6, THF‐α, ELAVL1, NLR family pyrin domain containing 3 (NLRP3), caspase‐1, and IL‐1β.Results: Lidocaine decreased the relative level of TG, TPO, T3, and T4 in adenovirus‐infected thyroid follicular epithelial cells. All levels of concentrations, including low, middle, and high, of lidocaine, significantly decreased the apoptosis rate of adenovirus‐infected cells. Lidocaine dramatically reduced the protein expression of IL‐1α, IL‐6, THF‐α, ELAVL1, NLRP3, caspase‐1, and IL‐1β in adenovirus‐infected thyroid follicular epithelial cells.Conclusion: Lidocaine can improve SAT through inhibiting expression of inflammatory factors and the pyroptosis pathway.
Human cytomegalovirus IL-10 augments NK cell cytotoxicity
Authors: Holder Kayla A , Grant Michael D 
Published: April 2019

Abstract
Human cytomegalovirus (HCMV) persistently infects most of the adult population with periods of productive and latent infection differentially orchestrated by multiple HCMV-encoded gene products. One HCMV gene (UL111a) encodes cmvIL-10, a virokine homologous to human IL (hIL)-10. Although the effects of cmvIL-10 on most human lymphocyte subsets have been extensively studied, its impact on NK cell function was unreported prior to this study. We investigated effects of short-term cmvIL-10 exposure on human NK cells and found it substantially enhanced NK cell cytotoxicity through natural cytotoxicity receptors NKp30 and NKp46 as well as through C-type lectin-like receptors NKG2C and NKG2D. Antibody-dependent cell-mediated cytotoxicity triggered through CD16 also increased significantly with short-term cmvIL-10 exposure. These effects of cmvIL-10 on NK cell cytotoxicity were rapid, dose dependent, neutralized by polyclonal anti-cmvIL-10 or monoclonal anti-IL-10 receptor (IL-10R) antibodies and independent of increased perforin synthesis or up-regulation of activating receptors. A low percentage (0.5–5.4%; n = 12) of NK cells expressed IL-10R and the impact of cmvIL-10 on NK cells degranulation following CD16 stimulation directly correlated with this percentage (P = 0.0218). Short-term exposure of human NK cells to cmvIL-10 did not introduce phenotypic changes reminiscent of NK adaptation to HCMV infection in vivo. Determining how expression of a viral protein that activates NK cells contributes to their function in vivo will increase understanding of HCMV infection and NK cell biology.
Comparative evaluation of the new GRPR‐antagonist 111In‐SB9 and 111In‐AMBA in prostate cancer models: Implications of in vivo stability
Authors: Lymperis Emmanouil , Kaloudi Aikaterini , Kanellopoulos Panagiotis , Krenning Eric P. , de Jong Marion , Maina Theodosia , Nock Berthold A. 
Published: April 2019

Gastrin‐releasing peptide receptors (GRPRs) are overexpressed in prostate cancer, representing attractive targets for diagnosis and therapy with bombesin (BBN)‐like radioligands. GRPR‐antagonists have lately attracted much attention owing to inherent biosafety and favorable pharmacokinetics. We herein present the GRPR‐antagonist SB9 structurally resembling the known BBN‐based agonist AMBA (SB9 = [Leu13NHEt‐desMet14]AMBA). The profiles of 111In‐SB9 and 111In‐AMBA were directly compared in PC‐3 cells and tumor‐bearing mice. SB9 and AMBA displayed high GRPR affinities. 111In‐AMBA strongly internalized in PC‐3 cells, while 111In‐SB9 remained bound on the cell surface showing a typical GRPR‐radioantagonist profile. 111In‐SB9 was more stable than 111In‐AMBA, but coinjection of the neprilysin (NEP) inhibitor phosphoramidon (PA) stabilized both in vivo. The radioligands displayed high tumor uptake (20.23 ± 3.41 %ID/g and 18.53 ± 1.54 %ID/g, respectively, at 4 hours pi), but 111In‐SB9 washed faster from background. PA coinjection led to significant increase of tumor uptake, combined with better clearance for 111In‐SB9. In short, this study has revealed superior pharmacokinetics and higher stability for the GRPR‐antagonist 111In‐SB9 vs the corresponding agonist 111In‐AMBA consolidating previous evidence that GRPR antagonists are preferable to agonists for tumor imaging and therapy. It has also demonstrated that further pharmacokinetic improvements were feasible by in situ metabolic radioligand stabilization using PA.
From hydroxyurethane methacrylates to hybrid nonisocyanate polyurethanes
Authors: Decostanzi Mélanie , Bonneaud Céline , Caillol Sylvain 
Published: April 2019

ABSTRACTNew hybrid polyhydroxyurethane networks were quantitatively synthesized by radical polymerization of new hydroxyurethane methacrylate (HUMA) prepolymers. These HUMAs were synthesized in several steps. First, bis(cyclic carbonate) poly(propylene oxide) was reacted with two different diamines (ethylene diamine and 2,2′‐(ethylenedioxy)diethylamine) in excess. Then, these end‐functionalized hydroxyurethane prepolymers were converted into end‐functionalized hydroxyl prepolymers by ring opening of ethylene carbonate. Finally, a methacrylate function was grafted to the hydroxyl functions. All these steps were performed at room temperature. These prepolymers were thermally either homopolymerized or copolymerized using benzylmethacrylate or poly(ethylene oxide) bisphenol A dimethacrylate as comonomers, leading to new hybrid nonisocyanate polyurethane networks with various properties. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019
Stability and water wetting behavior of superhydrophobic polyurethane films created by hot embossing and plasma etching and coating
Authors: Barz Jakob , Haupt Michael , Oehr Christian , Hirth Thomas , Grimmer Philipp 
Published: April 2019

AbstractThe surface characteristics, the stability against erosion, and the water wetting behavior of superhydrophobic polyurethane (PU) films are described. Hot embossing is used to imprint conical microstructures in PU films. Afterwards, about 200‐nm thick hydrophobic plasma polymers are deposited by PECVD, using different fluorocarbons (CHF3, C3F6, or C4F8) or hexamethyldisiloxane as precursors. Ar or O2 plasma etching is used to increase the surface nanoroughness. The plasma coatings show stability against sand abrasion and in a long‐term outdoor test but are completely degraded by an industrial UV/water weathering test. Superhydrophobicity is achieved on the coated microstructures with base diameters between 35 µm and 50 µm, top diameters between 14 µm and 20 µm, and distances between 50 µm and 70 µm.
Comparing the functional recognition of aesthetics, hydrology, and quality in urban stream restoration through the framework of environmental perception
Authors: Hong Chang‐Yu , Chang Heejun , Chung Eun‐Sung 
Published: April 2019

AbstractThis study explores the application of a civic perception analysis in the context of stream restoration as a social‐ecological system (SES). Analysing such a SES is useful for understanding correlations between civic interests and environmental conditions in river restoration. An analytic hierarchy process (AHP) analysis was used to quantify the demand for restoration objectives. Additionally, an image‐based survey was used to precisely capture residents' perceptions of urban stream restoration by comparing aesthetic images, hydrologic functions, and environmental quality. Based on the AHP results, a hierarchical multiple regression was derived. A total of 181 participants responded to our survey, and the results were summarized by each subwatershed in the An'Yang watershed. The results demonstrated that the perceptions of residents who live in various environmental and regional conditions may manifoldly reflect their personal visual and aesthetic preferences by subwatershed. The upstream subwatershed values (SW1 = 7.86 and SW2 = 7.39) were higher than those in the downstream areas (SW5 = 5.28 and SW6 = 5.15). Consequently, this hierarchical multilevel model showed that individual environmental perception was highly associated with visual preference regarding stream restoration at the subwatershed level (p < 0.001). Urban environmental and spatial planners could use such information when restoring and designing waterfront spaces.
Recent Advances in Growth and Modification of Graphene‐Based Energy Materials: From Chemical Vapor Deposition to Reduction of Graphene Oxide
Authors: Cai Le , Yu Gui 
Published: April 2019

AbstractGraphene is recognized as the next generation of energy materials due to its spectacular physical properties. Meanwhile, there are diverse synthetic methods toward graphene, and these methods have unique advantages to impel graphene to be suitable for different energy devices. Chemical vapor deposition and reduction of graphene oxide are classical methods for preparing graphene with various lattice structures and layer numbers, resulting in the tunability of graphene properties, whereby the synthetic methods have significant effects on energy device performances. Therefore, this review pays close attention to the discrepancies of graphene‐based materials prepared by these two methods for use in solar cells, rechargeable batteries, and electrocatalysis for hydrogen evolution. Furthermore, the modifications of graphene are introduced to offset the weaknesses of synthetic methods. Then, the review introduces graphene‐based flexible energy devices because graphene prepared by these two methods shows similarity in their mechanical stability. Finally, other synthetic methods are shortly highlighted to explain the importance of these two methods. The analyses for the discrepancies and similarity of graphene‐based materials in classical energy devices from the aspect of synthesis are beneficial to guide the preparation and modifications of graphene for maximizing its application and promote practical usage in the future.
A new VIKOR-based in-sample-out-of-sample classifier with application in bankruptcy prediction
Authors: Ouenniche Jamal , Bouslah Kais , Perez-Gladish Blanca , Xu Bing 
Published: April 2019

AbstractNowadays, business analytics has become a common buzzword in a range of industries, as companies are increasingly aware of the importance of high quality predictions to guide their pro-active planning exercises. The financial industry is amongst those industries where predictive analytics techniques are widely used to predict both continuous and discrete variables. Conceptually, the prediction of discrete variables comes down to addressing sorting problems, classification problems, or clustering problems. The focus of this paper is on classification problems as they are the most relevant in risk-class prediction in the financial industry. The contribution of this paper lies in proposing a new classifier that performs both in-sample and out-of-sample predictions, where in-sample predictions are devised with a new VIKOR-based classifier and out-of-sample predictions are devised with a CBR-based classifier trained on the risk class predictions provided by the proposed VIKOR-based classifier. The performance of this new non-parametric classification framework is tested on a dataset of firms in predicting bankruptcy. Our findings conclude that the proposed new classifier can deliver a very high predictive performance, which makes it a real contender in industry applications in finance and investment.
RETRACTED ARTICLE: The effects of a recruitment manoeuvre with positive end-expiratory pressure on lung compliance in patients undergoing robot-assisted laparoscopic radical prostatectomy
Authors: Kudoh Osamu , Satoh Daizoh , Hori Naosuke , Kawagoe Izumi , Inada Eiichi 
Published: April 2019

AbstractThe effects of a recruitment manoeuvre (RM) with positive end-expiratory pressure (PEEP) on lung compliance (CLUNG) are not well characterised in robot-assisted laparoscopic radical prostatectomy (RARP). Patients were allocated to group R (n = 10; with an RM) or C (n = 9; without an RM). An RM involved sustained inflation of 30 cmH2O for 30 s. The lungs were ventilated with volume-controlled ventilation with tidal volume of 7 mL kg−1 of predicted body weight and fraction of inspired oxygen of 0.5. End-tidal carbon dioxide pressure was maintained at normocapnia. Patients were in the horizontal lithotomy position (pre-op). After pneumoperitoneum, patients underwent RARP in a steep Trendelenburg lithotomy position at a PEEP level of 0 cmH2O (RARP0). An RM was used in the R group but not in the C group. Patients were then ventilated with 5 cmH2O PEEP for 1 h after RARP0 (RARP5.1) and 2 h after RARP0 (RARP5.2). Oesophageal pressure and airway pressure were measured for calculating CLUNG and chest wall compliance. CLUNG significantly decreased from pre-op to RARP0 and did not significantly increase from RARP0 to RARP5.1 and RARP5.2 in either group. CLUNG differed significantly between groups at RARP5.1 and RARP5.2 (103 ± 30 vs. 68 ± 11 mL cm−1 H2O and 106 ± 35 vs. 72 ± 9 mL cm−1 H2O; P < 0.05). In patients undergoing RARP, with the addition of RM, the CLUNG was effectively increased from the horizontal lithotomy position to the steep Trendelenburg lithotomy position under pneumoperitoneum.
Ski-Everest (8848 m) Expedition: Digit Skin Temperature Responses to Cold Immersion May Reflect Susceptibility to Cold Injury
Authors: Gorjanc Jurij , Morrison Shawnda A. , McDonnell Adam C. , Mekjavic Polona Jaki , Blagus Rok , Mekjavic Igor B. 
Published: April 2019

Introduction We tested the hypothesis that individual susceptibility to freezing cold injury might be reflected in an attenuated cold-induced vasodilatation (CIVD) response by comparing the CIVD responses of an elite alpinist with a history of freezing cold injury in the feet (case alpinist) with those of an age- and ability- matched noninjured alpinists control group (controls). According to this hypothesis, the vasomotor responses to a CIVD test of the case alpinist would represent a pathophysiological response when compared with the normal physiological response of a noninjured cohort. Methods The case alpinist and the controls in the cohort group conducted a cold water immersion test comprising sequential immersion of a hand and foot for 5 min in 35°C water, followed by a 30-min immersion in 8°C water and a 10-min recovery period in room air. During this test we monitored the finger and toe skin temperatures. Results The case alpinist had a significantly attenuated CIVD response and a lower skin temperature in all injured and noninjured digits during immersion (∼2°C lower than in the control group) and an attenuated recovery of finger skin temperatures (∼6°C lower than in the control group). Conclusions The attenuated CIVD response of the case alpinist may reflect a previously unrecognized enhanced susceptibility to frostbite. In addition to the poor vasomotor response observed in the injured toes, he also exhibited a poor vasomotor response in his noninjured fingers. The results of the present study indicate that a test of vasomotor activity during thermal stress may identify individuals predisposed to cold injury.
Cost-effectiveness of new drugs: A systematic review of published evidence for new chemical entity drugs introduced on the Swedish market 1987–2000
Authors: Lundkvist Jonas , Jönsson Bengt , Rehnberg Clas 
Published: April 2019

Objectives: The number of published economic evaluations has increased dramatically during the past decades, but the number of studies performed for different drugs varies substantially. The objective of this study was to analyze the amount of cost-effectiveness evidence for new drugs, by systematically reviewing the published evidence of cost-effectiveness.Methods: The study included 442 new chemical entities, approved in Sweden between 1987 and 2000. The amount of cost-effectiveness evidence was rated and analyzed together with information about sales and the therapeutic benefit of the drugs. Information about cost-effectiveness was obtained from the Health Economic Evaluation Database.Results: The results showed that most cost-effectiveness evidence was published approximately 1 to 5 years after the approval year and that very few articles were published before or during the approval year. More than half of the drugs did not have any evidence of their cost-effectiveness. A total of 51 of the evaluated drugs were considered having much evidence of cost-effectiveness, 84 drugs were considered having some evidence, and the remaining 307 drugs had little evidence. The analyses indicated that drugs with improved effectiveness or safety compared with other marked drugs had more evidence of cost-effectiveness and that drugs with low sale were likely to have less evidence of cost-effectiveness than drugs with high sale.Conclusions: The study indicated that the publication of cost-effectiveness information for new drugs introduced between 1987 and 2000 may be considered rather rational, that is, the economic evaluations were performed for drugs for which this information was most important.
International comparison and review of a health technology assessment skills program
Authors: Wanke Margaret I. , Juzwishin Don 
Published: April 2019

Objectives: A review of the Alberta Heritage Foundation for Medical Research's (AHFMR) 6-month Health Technology Skills Development Program was undertaken within an international context with the purpose of describing and assessing the current program, further formalizing the program based on identified opportunities for improvement, and enhancing collaborative linkages with other agencies. The objectives of the review were to (i) compare the AHFMR program with similar programs in other health technology assessment (HTA) agencies internationally; (ii) assess the value of the program; (iii) identify program strengths and opportunities for improvement; and (iv) review, critique, and recommend enhancements to the program model and role description.Methods: The review involved a qualitative study design that included a survey of the Skills Development Program participants' experience and perceptions; semistructured interviews with program stakeholders, and a written survey of HTA agencies/programs in other Canadian and international jurisdictions.Conclusions: The review concluded that the program was successful and valued by participants, the Foundation, and stakeholders in the policy and research communities. Findings suggest participant products have a potential for broad influence, including impact on funding decisions related to technology diffusion, influence through publications and presentations, and knowledge transfer in the participants' disciplines and employment settings. The main opportunity for enhancement was to differentiate the program into two streams according to different needs of participants, specifically between those who desire to be HTA producers and/or make HTA their careers, and those who desire to apply HTA in their employment capacity as policy or clinical decision-makers.
More on a friend of Philippe de Vitry: Johannes Rufi de CrucealiasJean de Savoie
Authors: WATHEY ANDREW 
Published: April 2019

AbstractWho was Jean de Savoie, the clerk with whom the composers Jean Campion and Philippe de Vitry penned the jeu-partiUlixea fulgensin 1350? This article uses Jean's hitherto unnoticed will and foundations at the church of Saint-Benoît-le-Bestourné, Paris, with other documentation, to bring together Jean's two identities in a unified biography (including a new date for his death, in 1354); to illustrate the close parallels between his own career and that of Philippe de Vitry, and to map the scope of opportunities for contact between them in and around the French royal court from the early 1320s onwards. Jean was also an artist and illustrator, and his career as one of the more prominent cartoonists of Philippe VI, king of France, throws light on potential contact with Vitry via the adoption by Louis I de Bourbon of the hitherto largely royal practice of charter illustration. In addition the properties acquired to support two chaplaincies endowed by Jean at Saint-Benoît demonstrate the extent to which he was professionally embedded in a network of royal councillors working in and around the Parlement in the 1330–50s, in which Vitry was also active. Also identified is a house acquired at Saint-Benoît by Gervès du Bus, author of the Roman de Fauvel.
Cantus figuratusand monastic re-figuration in the late medieval Veneto
Authors: REULAND JAMIE 
Published: April 2019

AbstractIn 1409 Ludovico Barbo arrived at the monastery of Santa Giustina in Padua, intent on its reformation. Since the late fourteenth century, the scriptorium at Santa Giustina had produced some of the most significant collections of polyphonic music to survive from the period, specialising in copying the avant-garde repertories of the Ars nova. Yet the reforms Barbo sought to introduce – reforms based on ideals he and a cohort of Venetians had been living out on the island of S. Giorgio in Alga – eschewed outward ostentation, and centred on prayerful engagement with the scene of Christ's Passion. Barbo's initiatives would seem at odds with the tradition of secular polyphony cultivated at the monastery in the years before his arrival. Official documents from the reform prohibit the practice of cantus figuratus and paint a picture of a uniformly spare music aesthetic.Manuscript and material evidence from Santa Giustina and dependent houses tells a different story, and suggests that communities found use for the monastery's musical past within the reformed practice of prayer and meditation. Vestiges of this past appear in the most unlikely of places: the Good Friday rituals that Barbo himself worked to strip of polyphonic accoutrement. The efforts of individual monks, musicians and scribes – here Rolando da Casale, whose musical expertise Barbo enlisted in the copying of new liturgical manuscripts, and Johannes Preottonus – emerge as telling examples of the ways in which institutional histories come under the pressure of their individual actors.