bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Systemic Inflammation in Cancer‐Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention
Authors: Cole Calvin L. , Kleckner Ian R. , Jatoi Aminah , Schwarz Edward M. , Dunne Richard F. 
Published: September 2018

AbstractProgressive skeletal muscle wasting in cancer cachexia involves a process of dysregulated protein synthesis and breakdown. This catabolism may be the result of mal‐nutrition, and an upregulation of both pro‐inflammatory cytokines and the ubiquitin proteasome pathway (UPP), which can subsequently increase myostatin and activin A release. The skeletal muscle wasting associated with cancer cachexia is clinically significant, it can contribute to treatment toxicity or the premature discontinuation of treatments resulting in increases in morbidity and mortality. Thus, there is a need for further investigation into the pathophysiology of muscle wasting in cancer cachexia to develop effective prophylactic and therapeutic interventions. Several studies have identified a central role for chronic‐systemic inflammation in initiating and perpetuating muscle wasting in patients with cancer. Interestingly, while exercise has shown efficacy in improving muscle quality, only recently have investigators begun to assess the impact that exercise has on chronic‐systemic inflammation. To put this new information into context with established paradigms, here we review several biological pathways (e.g. dysfunctional inflammatory response, hypothalamus pituitary adrenal axis, and increased myostatin/activin A activity) that may be responsible for the muscle wasting in patients with cancer. Additionally, we discuss the potential impact that exercise has on these pathways in the treatment of cancer‐related muscle wasting. Exercise is an attractive intervention for muscle wasting in this population, partially because it disrupts chronic‐systemic inflammation mediated catabolism. Most importantly, exercise is a potent stimulator of muscle synthesis, and therefore this therapy may reverse muscle damage caused by cancer cachexia.
Alteraciones y calidad del sueño en la población pediátrica entre los 4 a 16 años con diagnóstico de epilepsia versus niños sanos. Barranquilla, marzo-abril de 2015
Authors: Guerrero Karen , Redondo Katerinny , Álvarez Adolfo , Varela Lourdes 
Published: September 2018

Objetivo: Determinar las alteraciones y calidad del sueño en la población pediátrica entre los 4 a 16 años con diagnóstico de epilepsia versus niños sanos. Barranquilla marzo-abril de 2015.
Materiales y Métodos: Estudio analítico de casos y controles con aplicación de encuesta SDSC en 25 pacientes con diagnóstico de epilepsia, en consulta externa neuropediatría; estos fueron incluidos como casos. Igualmente se tomó un número pareado en cuanto a sexo y edad de la misma institución educativa de cada caso, y se le aplicó junto a sus padres encuesta SDSC.
Resultados: Trastornos de inicio y mantenimiento del sueño presentes en el 32 % de los casos frente al 12 % en controles, síndrome de piernas inquietas 24 % en los casos contra 16 % en controles, trastornos respiratorios del sueño 32 % en casos contra 12 % en controles, excesiva somnolencia diurna fue el principal trastorno en los casos con un 44 % frente a 16 % en los controles.
Conclusiones: Los pacientes pediátricos con epilepsia, presentan un riesgo seis veces mayor de presentar algún tipo de trastorno del sueño que la población pediátrica sin epilepsia.
Comportamiento clínico de pacientes con nefropatía lúpica y síndrome metabólico versus nefropatía lúpica sin síndrome metabólico. Clínica de la Costa, Barranquilla
Authors: Navarro Gabriel , Pardo Gerardo , Aroca Gustavo , Varela Lourdes 
Published: September 2018

Objetivo: Determinar el comportamiento clínico de pacientes con nefropatía lúpica y síndrome metabólico versus nefropatía lúpica sin síndrome metabólico. Clínica de la Costa, Barranquilla, periodo enero-mayo de 2015.
Materiales y Métodos: Estudio analítico de casos y controles en 40 pacientes con asociación de nefropatía lúpica + síndrome metabólico (grupo casos) seleccionándose igual número de controles de pacientes con nefropatía lúpica sin síndrome metabólico.
Resultados: Prevalencia de síndrome metabólico del 44,1 %; la proteinuria en 24 horas media de los casos fue de 1,2 ± 1,1 gr/24 hr contra 0,6 ± 0,3 gr/24 hr en los controles, la creatinina media de los casos se observó en 1,3 ± 0,6 mg/dl y de 0,8 ± 0,3 mg/dl en los controles, en los casos la depuración de creatinina fue de 71,2 ± 38,4 ml/min contra 92,7 ± 23,8 ml/min en los controles.
Conclusiones: Existe un mayor compromiso clínico en pacientes con nefropatía lúpica + síndrome metabólico, comparado con los pacientes con nefropatía lúpica sin síndrome metabólico.
KLASİK TÜRK ŞİİRİNE KLASİK OLMAYAN YAKLAŞIMLAR: BÂKÎ, YAHYÂ, NEDÎM ÖRNEĞİNDE KLİŞELERİN SORGULANMASI
Authors: Kuzu Fettah 
Published: September 2018

Günümüzde klasik Türk şiiri sahasındaki çalışmaların
temel problemlerinden biri, belli şairler ve şiirleri hakkında verilmiş
birtakım hükümlerin zaman içerisinde kesinlik kazanarak araştırmacıların ortak
görüşü hâline gelmesidir. İlk örnekleri tezkirelerde görülmeye başlanan şair ve
şiir eleştirisi zaman içerisinde edebiyat tarihlerinin yazılmasıyla gelişimini
sürdürmüş ve belli dönemlerin usta şairleri ve onların şiirleri hakkında önemli
değerlendirmeler yapılmıştır. Ancak edebî eleştiri sahasındaki bu çalışmalarda
şairler ve şiirleri ile ilgili ortaya koyulan değerlendirmeler zaman içerisinde
mutlak gerçekler olarak kabul edilmek suretiyle sorgulanması güç doğrulara
dönüşmüşlerdir. Bu çalışmada genelde sosyal bilimlerin özelde de edebiyat
araştırmalarının özüne aykırı biçimde dogmatik bir anlayışla mutlak doğrular
veya gerçekler olarak kabul edilen birtakım mülahazalar, klasik Türk
edebiyatının usta şairlerinden Bâkî, Şeyhülislam Yahyâ ve Nedîm hakkında ileri
sürülmüş birtakım hükümler çerçevesinde ele alınmaya çalışılacaktır.
Assessment of Multilingual Collections in Public Libraries: A Case Study of the Toronto Public Library
Authors: Ly Valentina 
Published: September 2018

Abstract
Objective – The Toronto Public Library has been frequently identified as having an exemplary multilingual collection to serve the information needs of the most diverse population in Canada; however, there is no evidence or collection assessment information available in the literature to validate those claims. This research sought to gain an understanding of the current state of their multilingual collection and compare it to the most recent multicultural population demographics.
Methods – This was a case study of the Toronto Public Library multilingual collection using data collected from their online public access catalogue in November 2017. Data was collected about all languages available, with English, French, and the 17 most spoken mother tongues explored in more detail. Language results from the Statistics Canada 2016 Census of Population were also collected. Data was used to calculate and compare the English, French, and language collections to the population of reported mother tongues spoken in Toronto.
Results – It was found that the Toronto Public Library has items in 307 languages. While the collection comprises many languages, there is far more focus on official language items than any other language compared to the population in terms of number of items and variety of formats. All 17 non-official languages that were studied had fewer items proportionally available in the catalogue than the proportion of speakers with that mother tongue.
Conclusion – The high circulation rates of the Toronto Public Library’s multilingual collection indicate that it has had some success in meeting the needs of its community. However, as the largest library system in Canada with a highly regarded multilingual collection and with many resources for collection development, the Toronto Public Library falls short of having a language collection that is proportional to the languages spoken within the community. While it may not be possible to have a multilingual collection that is entirely representative of the community, this study shows that libraries can use census data to monitor population shifts in order to be responsive to the information needs of their changing communities.
A re-examination of online journal quality and investigation of the possible impact of poor electronic surrogate quality on researchers
Authors: Ladd Ken 
Published: September 2018

Objective – This study re-examines the findings of a paper (Ladd, 2010) that investigated whether evidence indicated print equivalent journal collections needed to be preserved, based on the quality of their electronic surrogates. The current study investigates whether: 1) electronic surrogate articles that failed (i.e., the print equivalent article needed to be consulted to view all the content/information) in the first study had improved in quality; and 2) there was evidence that poor-quality electronic surrogates could impact on research if the print equivalent articles did not exist.
Methods – Each of the 198 PDF documents identified in the 2010 study as failing were re-examined to assess whether any change in quality had occurred. To assess the possible impact for researchers if they needed to rely solely on poor-quality electronic journal surrogates, citation data were collected for each of the failed scholarly PDFs using Web of Science and Scopus, and usage count data were collected from Web of Science.
Results – Across the electronic journal backfiles/archives examined, there were 13.6% fewer failures of electronic surrogates for all PDF documents than in the original study, while for scholarly PDF documents (e.g., research papers) there were 13.8% fewer failures. One electronic journal archive accounted for 91.7% of the improvement for scholarly PDF documents. A second archive accounted for all the observed improvement for non-scholarly PDF documents. The study found that for the failed scholarly PDF documents from the original study, 58.7% had been cited or had Web of Science usage counts from 2010 onward.
Conclusion – The study demonstrates a continued need for retaining print equivalent journal titles for the foreseeable future, while poor-quality electronic surrogates are being replaced and digitally preserved. There are still poor-quality images, poor-quality scans of text-only articles, missing pages, and even content of PDF documents that could not be explained (e.g., incorrect text for images when compared to the print). While it is known that not all researchers will consult each of the papers that they cite, although it is best practice to do so, the extent of citations of the failed scholarly PDF documents indicate that having to rely solely on electronic surrogates could pose a problem for researchers.
Molecular Dynamics and Inhibition of MERS CoV Papain-like Protease by Small Molecule Imidazole and Aminopurine Derivatives
Authors: Kandeel Mahmoud , Altaher Abdallah , Alnazawi Mohamed 
Published: September 2018

Background:
Middle East Respiratory Syndrome coronavirus (MERS CoV) is a newly
emerged viral disease with a fatal outcome.

Method:
During the search for new antiviral drugs, MERS CoV papain-like protease (Plpro) was
identified as a possible target. In this work, MERS CoV Plpro was investigated by virtual
screening, enzyme inhibition and molecular dynamics to find new inhibitors. After the virtual
screening of a dataset of small molecules, 5 compounds were selected for inhibitory studies.

Results:
Purine and imidazole-pyridine derivatives were identified as MERS CoV Plpro inhibitors
with Ki values of 73 and 68 µM, respectively. The binding of inhibitors showed marked changes
in both the fingers subdomain and Ubl domain, with negligible changes in the catalytic domain.
The binding of inhibitors was associated with the formation of favorable hydrogen bonds with the
side chains of Plpro S1648 or Y1760.

Conclusion:
Further optimization of the present set can lead to more potent inhibitors through the
design of small molecules with improved binding affinity.
Cloud Provider's Response to Multiple Models of Attack Behaviors
Authors: Liu Xu , Di Xiaoqiang , Li Jinqing , Yang Huamin , Cong Ligang , Zhao Jianping 
Published: September 2018

Background:
User behavior models have been widely used to simulate attack behaviors
in the security domain. We revised all patents related to response to attack behavior models. How to
decide the protected target against multiple models of attack behaviors is studied.

Methods:
We utilize one perfect rational and three bounded rational behavior models to simulate attack
behaviors in cloud computing, and then investigate cloud provider’s response based on
Stackelberg game. The cloud provider plays the role of defender and it is assumed to be intelligent
enough to predict the attack behavior model. Based on the prediction accuracy, two schemes are
built in two situations.

Results:
If the defender can predict the attack behavior model accurately, a single-objective game
model is built to find the optimal protection strategy; otherwise, a multi-objective game model is
built to find the optimal protection strategy.

Conclusion:
The numerical results prove that the game theoretic model performs better in the corresponding
situation.
Identification of Essential Proteins in Yeast Using Mean Weighted Average and Recursive Feature Elimination
Authors: Mani Sekhar Sivagnanam Rajamanickam , Matt Siddesh Gaddadevara , Manvi Sunilkumar S. , Gopalalyengar Srinivasa Krishnarajanagar 
Published: September 2018

Background:Essential proteins are significant for drug design, cell development, and for living organism survival. A different method has been developed to predict essential proteins by using topological feature, and biological features.Objective:Still it is a challenging task to predict essential proteins effectively and timely, as the availability of protein protein interaction data depends on network correctness.Methods:In the proposed solution, two approaches Mean Weighted Average and Recursive Feature Elimination is been used to predict essential proteins and compared to select the best one. In Mean Weighted Average consecutive slot data to be taken into aggregated count, to get the nearest value which considered as prescription for the best proteins for the slot, where as in Recursive Feature Elimination method whole data is spilt into different slots and essential protein for each slot is determined.Results:The result shows that the accuracy using Recursive Feature Elimination is at-least nine percentages superior when compared to Mean Weighted Average and Betweenness centrality.Conclusion:Essential proteins are made of genes which are essential for living being survival and drug design. Different approaches have been proposed to anticipate essential proteins using either experimental or computation methods. The experimental result show that the proposed work performs better than other approaches.
The Common Science Misconceptions in Indonesia Junior High School Students
Authors: Anjarsari Putri 
Published: September 2018

Identifying and correcting the mistake that students make about science concept is very important. The main purpose of this article is to analyse some publications about common science misconceptions in some science topics in junior high schools. Misconceptions are erroneous perceptions of what is universally accepted. The misconception identification in this research is based on the descriptive research using some journal publications in Indonesia university which is held science education study program. Study found that : the concept of photosynthesis, respirations, the relationship of photosynthesis and respirations, force (action and reaction forces) , and Newton laws are most frequently investigated as misconceptions of science. Students’ interest and learning environments are some reasons of students’ misconceptions.
Vascular Dysfunction, Oxidative Stress, and Inflammation in Autosomal Dominant Polycystic Kidney Disease
Authors: Nowak Kristen L. , Wang Wei , Farmer-Bailey Heather , Gitomer Berenice , Malaczewski Mikaela , Klawitter Jelena , Jovanovich Anna , Chonchol Michel 
Published: September 2018

Background and objectives
Both increased arterial stiffness and vascular endothelial dysfunction are evident in patients with autosomal dominant polycystic kidney disease, even early in the course of the disease when kidney function in preserved. Vascular dysfunction in autosomal dominant polycystic kidney disease is thought to be related to vascular oxidative stress and inflammation, but direct evidence is lacking.

Design, setting, participants, & measurements
We assessed carotid-femoral pulse-wave velocity (arterial stiffness) and brachial artery flow-mediated dilation (vascular endothelial function) in participants with early-stage autosomal dominant polycystic kidney disease (eGFR≥60 ml/min per 1.73 m2) and a history of controlled hypertension and in healthy controls. Brachial artery flow-mediated dilation was also assessed after infusion of ascorbic acid to inhibit vascular oxidative stress compared with saline. Vascular endothelial cells were collected from a peripheral vein to measure expression of proteins, and circulating markers were also assessed by ELISA or liquid chromatography-tandem mass spectrometry.

Results
In total, 61 participants with autosomal dominant polycystic kidney disease (34±9 years old [mean±SD]) and 19 healthy controls (30±5 years old) were studied. Carotid-femoral pulse-wave velocity was higher in participants with autosomal dominant polycystic kidney disease compared with healthy controls (650±131 versus 562±81 cm/s; P=0.007). Brachial artery flow-mediated dilation was 8.2%±5.8% in participants with autosomal dominant polycystic kidney disease and 10.8%±4.7% in controls (P=0.08). Among participants with autosomal dominant polycystic kidney disease, flow-mediated dilation increased from 7.7%±4.5% to 9.4%±5.2% with ascorbic acid, a difference of 1.72 (95% confidence interval, 0.80 to 2.63), whereas in control participants, flow-mediated dilation decreased nonsignificantly from 10.8%±4.7% to 10.6%±5.4%, a difference of −0.20 (95% confidence interval, −1.24 to 0.84; P interaction =0.02). Endothelial cell protein expression of NF-κB was greater in participants with autosomal dominant polycystic kidney disease (0.48±0.12 versus 0.41±0.10 [intensity versus human umbilical vein endothelial cell control]; P=0.03). However, circulating oxidative stress markers and bioactive lipid mediators did not significantly differ according to the autosomal dominant polycystic kidney disease diagnosis.

Conclusions
These results provide support for the hypothesis that vascular oxidative stress and inflammation develop with autosomal dominant polycystic kidney disease.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2018_09_18_CJASNPodcast_18_10_.mp3
Optimizing Period of Pre-Packaging and Pre-Planting of
Somatic Embryogenesis Cocoa Plantlets
Authors: Man santoso Teguh , Soedarsianto Soedarsianto , Bachri Syamsul 
Published: September 2018

AbstractPratylenchus coffeae is a parasitic nematoda that infected the roots of some plants, one of them is coffee. The Infection of Pratylenchus coffeae cause root tissue damage that led to root lession and make root become rotten, it will interfere the ability of roots to absorb water and nutrients in the soil which resulted in the growth of plants. At the moment, control of Pratylenchus coffeae are following integrated pests management (IPM) program, which integrated between the use of coffee resistant clone and application of biological agents. Research on biological control was conducted more intensive, at the moment; due to it is friendlier save against environment and cheaper then using chemical nematicides. The research was conducted to know the effects of Micorrhiza Helper Bacteria (MHB),Pseudomonas diminuta and Bacillus subtilis in suppressing the population of P. coffeaeas well as their effect on growth of coffee seedling. Coffee arabica (Coffea arabica L.) seedling one moth old were used in the experiment. The experiment prepared with eight treatments and five replications, as follows: A (Pseudomonas diminuta with density of 108 cfu / ml), B (Pseudomonas diminuta with density of 2x108 cfu / ml), C (Bacillus subtilis with density of 108 cfu / ml ), D (Bacillus subtilis with density 2x108 cfu / ml), E (Carbofuran nematicide 5 g formulation / pot), F (Pseudomonas diminuta and Bacillus subtilis with each density of 108 cfu / ml), K- (Nematoda inoculation but without bacteria and nematicide), K+ (coffee seedling without any additional treatment). The experiment was conducted for sixteen weeks or about four months. The results of the experiment showed that application of MHB could suppress population of P. coffeae and increase coffee seedling growth significantly. Inoculation of B. subtilis at 108 cfu per seedling suppressed significantly nematoda population of 71.3% compared with untreated seedling but inoculated with nematoda. It was not significant different with carbofuran treatment which could suppress nematoda population by 89.7%. The same result also occur on the treatment of P. diminuta at density level 2.108 cfu/seedling, which could suppress nematoda population by 64.2%. Seedling growth were treated with MHB also significantly increase compared with seedling without treatment and inoculation of nematodas, especially on the treatment of B.subtilis at density level 108 cfu and P.diminuta at density level of 108 cfu, with increasing level of 35.4% and 34.2 %, respectively.Keywords: MHB (Mycorrhiza Helper Bacteria), Arabica coffee (Coffea arabica L.), Pratylenchus coffeae, Bacillus subtilis, Pseudomonas diminuta.
Carbon stock in different ages and plantation system
of cocoa: allometric approach
Authors: Yuliasmara Fitria , Wibawa Aris , Prawoto Adi 
Published: September 2018

Cocoa (Theobroma cacao L.) like most tropical trees is recalcitrant in tissue culture. Somatic embryogenesis is generally efficient micropropagation technique to multiply elite material. However, Somatic embryogenesis in cocoa is difficult and this species is considered as recalcitrant. One of the factors often considered as a component of in vitro recalsitrance is a high phenolic content and oxidation of these compounds. In cocoa tissue culture accumulate large amounts of poliphenolics compounds which probably impair further development. This study was conducted to investigate the composition of phenolic compounds in cocoa flower and leaves, and their changes troughout the somatic embryogenesis process. Calli were induced in cacao floral and leaves explants on a half-strenght Murashige and Skoog medium containing 30 g/L Glucose and combination of 2,4 dichlorophenoxyacetic acid (2,4 D) with kinetin (kin). Total polyphenol content was observed on Sulawesi 1 cocoa clone. Embryogenic and non-embryogenic callus were also compared. The percentage of callus production from flower tissue is 85%, percentage of embryogenic callus 40 %, although the percentage of somatic embryo production from embryogenic callus callus is 70%. The conservation of callus into somatic embryos followed by decline in phenol content and an increase in peroxidase. The synthesis kinetics for these compounds in calli, under different somatic embryogenesis conditions, revealed a higher concentration under non-embryogenic conditions. So that, phenolic compound can influence the production of calli and an absence the phenolic compound can enhance production of somatic embryo.Kata kunci: Theobroma cacao L., polifenol, embrio somatik, kalus, flavonoid, katekin, in vitro recalcitance