bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Production Planning and Scheduling Method Based on Heuristic Rules for Forming-sintering Production System
Authors: Zhengmin Zhang , Zailin Guan , Lei Yue , Chuangjian Wang , Hao Wang 
Published: June 2019

Abstract
The forming-sintering process is the bottleneck of the magnetic material manufacturing system in general, which restricts the overall output of the workshop. It is hard to formulate a production plan due to the complex constraints in such production system. In current research, the production planning control framework integrated with DBR (Drum-Buffer-Rope) concept oriented for forming-sintering process is designed. Moreover, a heuristic method considering the constraints of the magnetic material production process is proposed, which standardize and optimize the preparation process of the forming-sintering production plan. The practical application indicates that the heuristic method greatly reduces the number of WIPs, shortens the order manufacturing cycle, and improves the on-time delivery rate and the utilization rate of the sintering furnace, as compared with the current planning method of the enterprise.
Collection and Storage of Assembly Quality Data of Complex Electromechanical Products
Authors: Liang Y , Zhang Q D , Zhao N , Duan H 
Published: June 2019

Abstract
In the context of made in China 2025 and intelligent manufacturing, “data-based decision” is one of the important concepts for quality management promotion, and data integrity and availability is an important aspect of data collection and data management. Combined with the characteristics of complex electromechanical products with complex structure, multiple development links and high quality requirements, this paper discusses the management category of quality big data from the perspective of manufacturing process operation management and product life cycle, studies the acquisition strategy by manual and automatic methods, acquisition process, the quality data modeling and expression specifications based on unified coding specifications and business flow and data flow framework and provides references for enterprises to carry out quality big data construction.
Research and Application of Bottleneck-based Planning and Scheduling Method for PCB Manufacturing System
Authors: Luo Dan , Guan Zailin , He Cong , Fang Weikang , Wang Chuangjian , Zeng Zhangyi 
Published: June 2019

Abstract
Researches on planning and scheduling of PCB production system are gaining more and more attention due to the complexity and uncertainty of it. Current research focused on the solving method how to make better schedule solution for PCB system based on a real case of PCB production enterprise. Firstly, for the bottleneck process of electroplating, a mixed integer programming model is proposed, moreover, a branch and bound method is employed to solve the problem. Secondly, for non-critical processes, the man-hour quota is predicted using the neural network model and the association rules, and then the data can be found using the association rules and be modified. Thirdly, the planning and scheduling method based on bottleneck is used for the order sequencing, and “pull-push” mechanism of Drum-Buffer-Rope are applied to generate the scheduling scheme for non-bottlenecks. In the end, the effectiveness of the proposed scheduling method is proved by computational experiments.
Research on Automatic Flow-shop Planning Problem Based on Data Driven Modelling Simulation and Optimization
Authors: Fang Weikang , Guan Zailin , Luo Dan , He Cong , Wang Hao , Wang Chuangjian 
Published: June 2019

Abstract
With the increasing demand for individualization, new smart manufacturing models are implemented in order to adapt to the market demands of high quality, multi-variety and fast delivery. However, new problems in production and operation are urgently needed for research. It is especially significant to study the automatic flow workshop planning based on data-driven modelling and simulation. Firstly, according to the rapid analysis of various data of the workshop, UML-based object-oriented data model is formulated. Then the application module of data-driven simulation modelling is established by using the simulation platform. The bottleneck recognition based simulation optimization module for the tabu search algorithm with guiding rules is designed. Data-driven modelling makes the model more flexible and reusable which can run a variety of different experiments by modifying the external data to drive simulation model. Finally, experiments are conducted to verify the effectiveness of the simulation optimization method proposed in current study. In addition an optimized production line configuration plan is provided.
Research on Pose Estimation of Mobile Robot Based on Convolutional Neural Network
Authors: Yue Min , Fu Guangyuan , Wu Ming 
Published: June 2019

Abstract
In this paper, we propose a new learning scheme for generating camera pose to be used for visual odometry. Pose estimation of mobile robot in unknown environment is formulated as a learning problem. We train a convolutional neural network end to end to compute the 6-dof pose of the robot from a series of images. The architecture is a kind of residual network with multiple attention resblocks, which can give features different weights in order to improve the accuracy of pose prediction. The network estimates ego-motion taking monocular image sequences as input instead of separate images. We call this novel network architecture Posenet. Compared to traditional methods, results are more accurate and in which we can see the potential of pose estimation methods with convolutional neural network.
Femtosecond Laser Double Pulses Nanofabrication on Silicon
Authors: Zhang Jin , Wang Sumei , Wang Mengmeng , Chu Zhuyuan 
Published: June 2019

Abstract
The temporal shaping femtosecond (fs) laser is realized by dividing a fs laser pulse into two identical sub-pulses. The double-pulse fs laser can be used to effectively control the initial free electron state such as electron temperature, capacity and density, etc. to improve the surface morphology quality. In this experiment, silicon was fabricated using the double-pulse fs laser. It was found that the average diameter of ablated micro-or nanoholes decreases with the increasing pulse delay (up to 1.5 ps) under the same laser fluence and the phenomenon was explained quantitatively by the plasma model. Furthermore, nanoholes were achieved using the double-pulse fs laser, which cannot be obtained by single pulse laser, and the processing size can be reduced to below 200 nm.
The functor of singular chains detects weak homotopy equivalences
Authors: Rivera Manuel , Wierstra Felix , Zeinalian Mahmoud 
Published: June 2019

The normalized singular chains of a path connected pointed space

X
X

may be considered as a connected

E

∞

E_{\infty }

-coalgebra

C

∗

(
X
)

\mathbf {C}_*(X)

with the property that the

0
0

th homology of its cobar construction, which is naturally a cocommutative bialgebra, has an antipode; i.e., it is a cocommutative Hopf algebra. We prove that a continuous map of path connected pointed spaces

f
:
X
→
Y

f: X\to Y

is a weak homotopy equivalence if and only if

C

∗

(
f
)
:

C

∗

(
X
)
→

C

∗

(
Y
)

\mathbf {C}_*(f): \mathbf {C}_*(X)\to \mathbf {C}_*(Y)

is an

Ω

\mathbf {\Omega }

-quasi-isomorphism, i.e., a quasi-isomorphism of dg algebras after applying the cobar functor

Ω

\mathbf {\Omega }

to the underlying dg coassociative coalgebras. The proof is based on combining a classical theorem of Whitehead together with the observation that the fundamental group functor and the data of a local system over a space may be described functorially from the algebraic structure of the singular chains.
On some embeddings between the cyclotomic quiver Hecke algebras
Authors: Zhou Kai , Hu Jun 
Published: June 2019

Let

I
I

be a finite index set and let

A
=
(

a

i
j

)

i
,
j
∈
I

A=(a_{ij})_{i,j\in I}

be an arbitrary indecomposable symmetrizable generalized Cartan matrix. Let

Q
+

Q^+

be the positive root lattice and

P
+

P^+

the set of dominant weights. For any

β
∈

Q
+

\beta \in Q^+

and

Λ
∈

P
+

\Lambda \in P^+

, let

R

β

Λ

\mathscr {R}_{\beta }^{\Lambda }

be the corresponding cyclotomic quiver Hecke algebra over a field

K
K

. For each

i
∈
I

i\in I

, there is a natural unital algebra homomorphism

ι

β
,
i

\iota _{\beta ,i}

from

R

β

Λ

\mathscr {R}_{\beta }^{\Lambda }

to

e
(
β
,
i
)

R

β
+

α
i

Λ

e
(
β
,
i
)

e(\beta ,i)\mathscr {R}_{\beta +\alpha _i}^{\Lambda }e(\beta ,i)

. In this paper we show that the homomorphism

ι
β

:=

⨁

i
∈
I

ι

β
,
i

:

R

β

Λ

→

⨁

i
∈
I

e
(
β
,
i
)

R

β
+

α
i

Λ

e
(
β
,
i
)

\iota _\beta :=\bigoplus _{i\in I}\iota _{\beta ,i}: \mathscr {R}_{\beta }^{\Lambda }\rightarrow \bigoplus _{i\in I}e(\beta ,i)\mathscr {R}_{\beta +\alpha _i}^{\Lambda }e(\beta ,i)

is always injective unless

β
=
0

\beta =0

and

ℓ
(
Λ
)
=
0

\ell (\Lambda )=0

or

A
A

is of finite type and

β
=
Λ
−

w
0

Λ

\beta =\Lambda -w_0\Lambda

, where

w
0

w_0

is the unique longest element in the finite Weyl group associated to the finite Cartan matrix

A
A

, and

ℓ
(
Λ
)

\ell (\Lambda )

is the level of

Λ
\Lambda

.
Breast Implant Prevalence in the Dutch Female Population Assessed by Chest Radiographs
Authors: de Boer Mintsje , van Middelkoop Michele , Hauptmann Michael , van der Bijl Noortje , Bosmans Jorn A W , Hendriks-Brouwer Narda , Schop Sijmen J , de Boer Jan Paul , Hijmering Nathalie J , Overbeek Lucy I H , Lobbes Marc B I , Klazen Caroline A H , de Jong Daphne , Rakhorst Hinne A , van der Hulst René R W J , van Leeuwen Flora E 
Published: June 2019

Abstract

Background
Breast implant-related health problems are a subject of fierce debate. Reliable population-based estimates of implant prevalence rates are not available, however, due to a lack of historical registries and incomplete sales data, precluding absolute risk assessments.

Objectives
This study aimed to describe the methodology of a novel procedure to determine Dutch breast implant prevalence based on the evaluation of routine chest radiographs.

Methods
The validity of the new method was first examined in a separate study. Eight reviewers examined a series of 180 chest radiographs with (n = 60) or without (n = 120) a breast implant confirmed by a computed tomography or magnetic resonance imaging scan. After a consensus meeting with best-performing expert reviewers, we reviewed 3000 chest radiographs of women aged 20 to 70 years in 2 large regional hospitals in the Netherlands in 2015. To calculate the national breast implant prevalence, regional prevalence variations were corrected utilizing the National Breast Cancer Screening Program.

Results
Eight reviewers scored with a median sensitivity of 71.7% (range, 41.7%-85.0%) and a median specificity of 94.6% (range, 73.4%-97.5%). After a consensus meeting and a reevaluation by best-performing expert reviewers, sensitivity was 79.9% and specificity was 99.2%. The estimated national prevalence of breast implants among women between 20 and 70 years was 3.0%, ranging from 1.7% at 21 to 30 years to 3.9% between 51 and 60 years.

Conclusions
The novel method in this study was validated with a high sensitivity and specificity, resulting in accurate prevalence estimates and providing the opportunity to conduct absolute risk assessment studies on the health consequences of breast implants.

Level of Evidence: 2
Sub-dominant principal components inform new vaccine targets for HIV Gag
Authors: Ahmed Syed Faraz , Quadeer Ahmed A , Morales-Jimenez David , McKay Matthew R 
Published: June 2019

Abstract

Motivation
Patterns of mutational correlations, learnt from patient-derived sequences of human immunodeficiency virus (HIV) proteins, are informative of biochemically linked networks of interacting sites that may enable viral escape from the host immune system. Accurate identification of these networks is important for rationally designing vaccines which can effectively block immune escape pathways. Previous computational methods have partly identified such networks by examining the principal components (PCs) of the mutational correlation matrix of HIV Gag proteins. However, driven by a conservative approach, these methods analyze the few dominant (strongest) PCs, potentially missing information embedded within the sub-dominant (relatively weaker) ones that may be important for vaccine design.

Results
By using sequence data for HIV Gag, complemented by model-based simulations, we revealed that certain networks of interacting sites that appear important for vaccine design purposes are not accurately reflected by the dominant PCs. Rather, these networks are encoded jointly by both dominant and sub-dominant PCs. By incorporating information from the sub-dominant PCs, we identified a network of interacting sites of HIV Gag that associated very strongly with viral control. Based on this network, we propose several new candidates for a potent T-cell-based HIV vaccine.

Availability and implementation
Accession numbers of all sequences used and the source code scripts for all analysis and figures reported in this work are available online at https://github.com/faraz107/HIV-Gag-Immunogens.

Supplementary information
Supplementary data are available at Bioinformatics online.
Estimating Long-term Tuberculosis Reactivation Rates in Australian Migrants
Authors: Dale Katie D , Trauer James M , Dodd Peter J , Houben Rein M G J , Denholm Justin T 
Published: June 2019

AbstractBackgroundThe risk of progression to tuberculosis (TB) disease is greatest soon after infection, yet disease may occur many years or decades later. However, rates of TB reactivation long after infection remain poorly quantified. Australia has a low incidence of TB and most cases occur among migrants. We explored how TB rates in Australian migrants varied with time from migration, age, and gender.MethodsWe combined TB notifications in census years 2006, 2011, and 2016 with time- and country-specific estimates of latent TB prevalences in migrant cohorts to quantify postmigration reactivation rates.ResultsDuring the census years, 3246 TB cases occurred among an estimated 2 084 000 migrants with latent TB. There were consistent trends in postmigration reactivation rates, which appeared to be dependent on both time from migration and age. Rates were lower in cohorts with increasing time, until at least 20 years from migration, and on this background there also appeared to be increasing rates during youth (15–24 years of age) and in those aged 70 years and above. Within 5 years of migration, annual reactivation rates were approximately 400 per 100 000 (uncertainty interval [UI] 320–480), dropping to 170 (UI 130–220) from 5 to 10 years and 110 (UI 70–160) from 10 to 20 years, then sustaining at 60–70 per 100 000 up to 60 years from migration. Rates varied depending on age at migration.ConclusionsPostmigration reactivation rates appeared to show dependency on both time from migration and age. This approach to quantifying reactivation risks will enable evaluations of the potential impacts of TB control and elimination strategies.
Pyronaridine-artesunate Efficacy and Safety in Uncomplicated Plasmodium falciparum Malaria in Areas of Artemisinin-resistant Falciparum in Viet Nam (2017–2018)
Authors: Quang Bui Phuc , Hong Huynh Quang , Thanh Tran Duong , Thanh Le Dong , Quang Nguyen Thieu , Van Truong Hanh , Khim Nimol , Witkowski Benoit , Cong Tran Dai , Bustos Maria Dorina , Ringwald Pascal , Thi Ta Tinh 
Published: June 2019

Abstract

Background
Multidrug-resistant Plasmodium falciparum undermines the efficacy of currently deployed antimalarial therapies in southern Viet Nam.

Methods
Between May 2017 and December 2018, this prospective, open-label, single-arm, observational clinical trial, conducted in Binh Phuoc, Dak Nong, Gia Lai, Khanh Hoa, and Ninh Thuan provinces, evaluated the safety and efficacy of oral pyronaridine-artesunate once daily for 3 consecutive days in adults and children with microscopically confirmed P. falciparum malaria. Patients were treated as inpatients for Days 0–3, with follow-up visits on Days 7, 14, 21, 28, 35, and 42. The primary outcome was the proportion of polymerase chain reaction (PCR)-adjusted adequate clinical and parasitological response (ACPR) at Day 42.

Results
The cumulative incidence of PCR-adjusted ACPR at Day 42 was 96.1% (95% confidence interval [CI] 91.4–98.2; Kaplan–Meier). In the per-protocol analysis, the proportion of patients with Day 42 PCR-adjusted ACPR was 96.1% (147/153; 95% CI 91.7–98.5). The proportion of patients with parasitemia at Day 3 was 24.0% (40/167; 95% CI 17.7–31.2). The prevalences of the Kelch13 (C580Y) mutation were: in Binh Phuoc, 97.7% (43/44); in Dak Nong, 96.2% (25/26); in Gia Lai, 57.8% (37/64); in Khanh Hoa, 66.6% (6/9); and in Ninh Thuan, 3.6% (1/28). The majority of artemisinin-resistant isolates also had increased plasmepsin2 copy number (75.9%; 85/112). There was 1 isolate (Binh Phuoc) that had Kelch13 (C580Y) plus increased plasmepsin2 and Pfmdr1 copy numbers. Asymptomatic transient increases in alanine transaminase and aspartate transaminase were observed at Day 7, resolving by Day 28.

Conclusions
Pyronaridine-artesunate can be used to diversify antimalarial therapy in areas of artemisinin-resistant P. falciparum in Viet Nam.

Clinical Trials Registration
ACTRN12618001274268.
Natural Clostridioides difficile Toxin Immunization in Colonized Infants
Authors: Kociolek Larry K , Espinosa Robyn O , Gerding Dale N , Hauser Alan R , Ozer Egon A , Budz Maria , Balaji Aakash , Chen Xinhua , Tanz Robert R , Yalcinkaya Nazli , Conner Margaret E , Savidge Tor , Kelly Ciaran P 
Published: June 2019

Abstract

Background
Clostridioides (Clostridium) difficile colonization is common among infants. Serological sequelae of infant C. difficile colonization are poorly understood.

Methods
In this prospective cohort study of healthy infants, stools serially collected between ages 1-2 and 9-12 months were tested for non-toxigenic and toxigenic C. difficile (TCD). Cultured isolates underwent whole-genome sequencing. Serum collected at 9–12 months underwent measurement of IgA, IgG, and IgM against TCD toxins A and B and neutralizing antibody (NAb) titers against toxin B. For comparison, antitoxin IgG and NAb were measured in cord blood from 50 mothers unrelated to study infants.

Results
Among 32 infants, 16 (50%) were colonized with TCD; 12 were first colonized &gt;1 month before serology measurements. A variety of sequence types were identified, and there was evidence of putative in-home (enrolled siblings) and outpatient clinic transmission. Infants first colonized with TCD &gt;1 month prior had significantly greater serum antitoxin IgA and IgG against toxins A (P = .02 for both) and B (P = .009 and .008, respectively) compared with non–TCD-colonized infants, and greater IgG compared with unrelated cord blood (P = .005). Five of 12 (42%) colonized infants had detectable NAb titers compared with zero non–TCD-colonized infants (P = .02). Breastfeeding was not associated with differences in serological measurements.

Conclusions
TCD colonization is associated with a humoral immune response against toxins A and B, with evidence of toxin B neutralization in vitro. The extent and duration of protection against CDI later in life afforded by natural C. difficile immunization events require further investigation.
Phased genome sequence of an interspecific hybrid flowering cherry, ‘Somei-Yoshino’ (Cerasus × yedoensis)
Authors: Shirasawa Kenta , Esumi Tomoya , Hirakawa Hideki , Tanaka Hideyuki , Itai Akihiro , Ghelfi Andrea , Nagasaki Hideki , Isobe Sachiko 
Published: June 2019

Abstract
We report the phased genome sequence of an interspecific hybrid, the flowering cherry ‘Somei-Yoshino’ (Cerasus × yedoensis). The sequence data were obtained by single-molecule real-time sequencing technology, split into two subsets based on genome information of the two probable ancestors, and assembled to obtain two haplotype phased genome sequences of the interspecific hybrid. The resultant genome assembly consisting of the two haplotype sequences spanned 690.1 Mb with 4,552 contigs and an N50 length of 1.0 Mb. We predicted 95,076 high-confidence genes, including 94.9% of the core eukaryotic genes. Based on a high-density genetic map, we established a pair of eight pseudomolecule sequences, with highly conserved structures between the two haplotype sequences with 2.4 million sequence variants. A whole genome resequencing analysis of flowering cherries suggested that ‘Somei-Yoshino’ might be derived from a cross between C. spachiana and either C. speciosa or its relatives. A time-course transcriptome analysis of floral buds and flowers suggested comprehensive changes in gene expression in floral bud development towards flowering. These genome and transcriptome data are expected to provide insights into the evolution and cultivation of flowering cherry and the molecular mechanism underlying flowering.
Lead extraction for cardiac implantable electronic device infection: comparable complication rates with or without abandoned leads
Authors: Bracke Frank , Verberkmoes Niels , van 't Veer Marcel , van Gelder Berry 
Published: June 2019

Abstract

Aims
Abandoned leads are often linked to complications during lead extraction, prompting pre-emptive extraction if leads become non-functional. We examined their influence on complications when extracted for device-related infection.

Methods and results
All patients undergoing lead extraction for device-related infection from 2006 to 2017 in our hospital were included. The primary endpoint was major complications. Out of 500 patients, 141 had abandoned leads, of whom 75% had only one abandoned lead. Median cumulative implant times were 24.2 (interquartile range 15.6–38.2) and 11.6 (5.6–17.4), respectively years with or without abandoned leads. All leads were extracted only with a femoral approach in 50.4% of patients. Mechanical rotational tools were introduced in 2014 and used in 22.2% of cases and replacing laser sheaths that were used in 5% of patients. Major complications occurred in 0.7% of patients with abandoned leads compared with 1.7% of patients with only active leads (P = 0.679). Failure to completely remove all leads was 14.9% and 6.4%, respectively with or without abandoned leads (P = 0.003), and clinical failure was 6.4% and 2.2% (P = 0.028), respectively. Procedural failure dropped to 9.2% and 5.7% (P = 0.37), respectively after the introduction of mechanical rotational tools. The only independent predictor of procedural and clinical failure in multivariate analysis was the cumulative implant duration.

Conclusion
Despite longer implant times, patients with abandoned leads did not have more major complications during lead extraction. Therefore, preventive extraction of non-functional leads to avoid complications at a later stage is not warranted.