bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERAN SERTA MASYARAKAT DALAM MENINGKATKAN STATUS KESEHATAN IBU DI KABUPATEN TIMOR TENGAH SELATAN
Authors: Pawitaningtyas Indah , Puspasari Herti Windya 
Published: October 2018

Over the past few years, Timor Tengah Selatan donated the highest number of maternal mortality and infant mortality rates for NTT Province compared to other districts/ cities. In 2012, in Timor Tengah Selatan 25 mother died and as many as 93 children, including infants died. This study is a qualitative study aimed to determine community’s role in attemp to improve maternal health status at Timor Tengah Selatan. Data collection was conducted during March-November 2012 through in-depth interviews and focus group discussions. The result showed that there is community participation of cadres and community leaders as a motivator in improving maternal health status in South Central Timor district. They have also been doing their role in formulating policy in their village such as the agreement that no more birth process is done at home especially by the only help of traditional birth attendant. Their efforts did not mean without the support of health care facilities and good infrastructure. We need a facilitation from health personnel as facilitator for cadres and community leaders and development for better infrastructure.

ABSTRAK
Selama beberapa tahun terakhir, Kabupaten Timor Tengah Selatan menyumbang angka tertinggi kematian ibu dan kematian bayi bagi Provinsi NTT dibandingkan dengan kabupaten/ kota yang lain. Pada tahun 2012, di Kabupaten Timor Tengah Selatan 25 ibu meninggal dunia dan sebanyak 93 anak termasuk bayi meninggal dunia. Penelitian ini merupakan penelitian kualitatif yang bertujuan untuk mengetahui peran serta masyarakat dalam meningkatkan status kesehatan maternal di kabupaten Timor Tengah Selatan. Pengumpulan data dilakukan selama bulan Maret–November 2012 dengan cara melakukan wawancara mendalam dan focus group discussion. Penelitian menunjukkan bahwa ada peran serta masyarakat yaitu kader dan tokoh masyarakat sebagai motivator dalam meningkatkan status kesehatan maternal di kabupaten Timor Tengah Selatan. Selain itu kader dan tokoh masyarakat mempunyai peran dalam menyusun kebijakan tingkat desa dalam hal ini yaitu adanya kesepakatan bahwa tidak ada lagi proses kelahiran yang dilakukan di rumah apalagi hanya dengan bantuan dukun bersalin. Upaya mereka tidaklah berarti tanpa dukungan fasilitas pelayanan kesehatan dan infrastruktur wilayah yang baik. Perlu pendampingan yang berkesinambungan dari tenaga kesehatan sebagai fasilitator bagi kader dan tokoh masyarakat serta pembangunan infrastruktur yang lebih baik.
Racial and Ethnic Differences in Anthropometric Measures as Risk Factors for Diabetes
Authors: Luo Juhua , Hendryx Michael , Laddu Deepika , Phillips Lawrence S. , Chlebowski Rowan , LeBlanc Erin S. , Allison David B. , Nelson Dorothy A. , Li Yueyao , Rosal Milagros C. , Stefanick Marcia L. , Manson JoAnn E. 
Published: October 2018

OBJECTIVE
The study objective was to examine the impact of race/ethnicity on associations between anthropometric measures and diabetes risk.

RESEARCH DESIGN AND METHODS
A total of 136,112 postmenopausal women aged 50–79 years participating in the Women’s Health Initiative without baseline cancer or diabetes were followed for 14.6 years. BMI, waist circumference (WC), and waist-to-hip ratio (WHR) were measured in all participants, and a subset of 9,695 had assessment of whole-body fat mass, whole-body percent fat, trunk fat mass, and leg fat mass by DXA. Incident diabetes was assessed via self-report. Multivariate Cox proportional hazards regression models were used to assess associations between anthropometrics and diabetes incidence.

RESULTS
During follow-up, 18,706 cases of incident diabetes were identified. BMI, WC, and WHR were all positively associated with diabetes risk in each racial and ethnic group. WC had the strongest association with risk of diabetes across all racial and ethnic groups. Compared with non-Hispanic whites, associations with WC were weaker in black women (P &lt; 0.0001) and stronger in Asian women (P &lt; 0.0001). Among women with DXA determinations, black women had a weaker association with whole-body fat (P = 0.02) but a stronger association with trunk-to-leg fat ratio (P = 0.03) compared with white women.

CONCLUSIONS
In postmenopausal women across all racial/ethnic groups, WC was a better predictor of diabetes risk, especially for Asian women. Better anthropometric measures that reflect trunk-to-leg fat ratio may improve diabetes risk assessment for black women.
Validation of Time in Range as an Outcome Measure for Diabetes Clinical Trials
Authors: Beck Roy W. , Bergenstal Richard M. , Riddlesworth Tonya D. , Kollman Craig , Li Zhaomian , Brown Adam S. , Close Kelly L. 
Published: October 2018

OBJECTIVE
This study evaluated the association of time in range (TIR) of 70–180 mg/dL (3.9–10 mmol/L) with the development or progression of retinopathy and development of microalbuminuria using the Diabetes Control and Complications Trial (DCCT) data set in order to validate the use of TIR as an outcome measure for clinical trials.

RESEARCH DESIGN AND METHODS
In the DCCT, blood glucose concentrations were measured at a central laboratory from seven fingerstick samples (seven-point testing: pre- and 90-min postmeals and at bedtime) collected during 1 day every 3 months. Retinopathy progression was assessed every 6 months and urinary microalbuminuria development every 12 months. Proportional hazards models were used to assess the association of TIR and other glycemic metrics, computed from the seven-point fingerstick data, with the rate of development of microvascular complications.

RESULTS
Mean TIR of seven-point profiles for the 1,440 participants was 41 ± 16%. The hazard rate of development of retinopathy progression was increased by 64% (95% CI 51–78), and development of the microalbuminuria outcome was increased by 40% (95% CI 25–56), for each 10 percentage points lower TIR (P &lt; 0.001 for each). Results were similar for mean glucose and hyperglycemia metrics.

CONCLUSIONS
Based on these results, a compelling case can be made that TIR is strongly associated with the risk of microvascular complications and should be an acceptable end point for clinical trials. Although hemoglobin A1c remains a valuable outcome metric in clinical trials, TIR and other glycemic metrics—especially when measured with continuous glucose monitoring—add value as outcome measures in many studies.
Genetic structure of populations of several endangered and endemic Dianthus species revealed by microsatellite markers
Authors: Butiuc-Keul Anca , Crăciunaș Cornelia , Goia Irina , Farkas Anca , Jarda Liliana , Cristea Victoria 
Published: October 2018

Abstract
In order to develop a proper conservation programme for several endangered, rare or endemic species of Dianhtus from Romania, molecular characterization by simple sequence repeat (SSR) markers has been accomplished. Amplification of SSR loci in individuals belonging to different populations of D. callizonus, D. glacialis ssp. gelidus, D. henteri, D. nardiformis and D. tenuifolius revealed 23 polymorphic alleles. D. callizonus and D. tenuifolius showed particular sets of SSR alleles. D. glacialis ssp. gelidus, D. henteri and D. nardiformis proved to share almost the same alleles in most of the loci. The highest genetic diversity was observed in D. glacialis ssp. gelidus and D. tenuifolius in locus MS-DINMADSBOX. Allelic patterns across Dianthus species indicate that the mean number of different alleles was highest in D. glacialis ssp. gelidus, while the number of effective alleles was highest in D. tenuifolius. There are no particular differences in individuals belonging to the same species. Genetic diversity is generally low, ranging from 0.18 (D. callizonus) to 0.44 (D. henteri). Regarding the genetic diversity within populations of the same species, no differences were revealed by the use of the SSR markers tested in the present study.
Adding Bricks to Clicks: On the Role of Physical Stores in a World of Online Shopping
Authors: Avery Jill , Steenburgh Thomas J. , Deighton John , Caravella Mary 
Published: October 2018

Abstract
E-commerce is gaining ground and leaving the role of traditional brick-and-mortar stores open to question. With this in mind, a team of researchers performed a case study to determine what effects the store openings of one multichannel retailer of fashion, home furnishings and high-end accessories would have on its catalog and online sales. The opening of brick-and-mortar stores had positive and negative effects for the retailer, but complementary consequences clearly outweighed sales drops in individual channels: In the short term, only catalog sales declined slightly. But over time, both the catalog and online channels increasingly benefited from the presence of the new brick-and-mortar stores. Within 79 months, catalog sales recovered to a level that would have been expected had the store never opened and subsequently continued growing more than in a sample without new stores. An enhanced understanding of both positive and negative cross-channel effects helps retailers better anticipate and respond to changes in sales in existing channels when a new one is added. It is the basis for strategically managing a company’s channels as a portfolio rather than as separate entities.
Assessment of phytoaccumulation of trace elements in medicinal plants from natural habitats
Authors: Tomaszewska-Sowa Magdalena , Kobierski Mirosław , Sawilska Anna Katarzyna , Figas Anna 
Published: October 2018

Summary

Introduction: The high concentration of some trace elements in medicinal plants may lowering the value of herbal material, and may cause poisoning effects.

Objective: The aim of this research was to evaluate the content of trace elements in the organs of: sandy everlasting, yarrow and stinging nettle.

Methods: In the soil samples, the grain size composition, pH, the content of carbon and nitrogen were determined. In the plant material and for the soil samples, the total contents of Zn, Cu, Mn, Fe, Pb were assayed. The values of the bioconcentration factor and translocation factor were also calculated.

Results: The concentration of metals in plant tissues followed in order: Fe>Mn>Zn>Pb>Cu>Hg. The studied species of medicinal plants accumulated mainly Zn, Pb and Hg. It was also shown a high Hg mobility and a low Pb mobility which mainly accumulated in the roots.

Conclusions: As our research shows the plants used in phytotherapy, should come from plantations monitored for toxic heavy metals in soil.
Expression of genes modulated by epigallocatechin-3-gallate in breast cancer cells
Authors: Bogacz Anna , Wolek Marlena , Juskowiak Bogna , Karasiewicz Monika , Kamiński Adam , Uzar Izabela , Polaszewska Anna , Kostrzewa Zofia , Czerny Bogusław 
Published: October 2018

Summary

Introduction: Breast cancer is the most common malignant cancer among women. Both drug resistance and metastasis are major problems in the treatment of breast cancer. Therefore, adjuvant therapy may improve patients’ survival and affect their quality of life. It is suggested that epigallocatechin gallate (EGCG) which is well known for its chemopreventive activity and acts on numerous molecular targets may inhibit the growth and metastasis of some cancers. Hence, discovering the metastatic molecular mechanisms for breast cancer may be useful for therapy.

Objective: The aim of the study was to determine the effect of EGGC on the mRNA expression level of genes such as ZEB1, ABCB1, MDM2, TWIST1 and PTEN in MCF-7 breast cancer cells.

Methods: MCF7/DOX were cultured in the presence of 0.2 μM DOX and EGCG (20-50 μM). The mRNA expression level was determined by real-time quantitative PCR using RealTime ready Custom Panel 96 kit.

Results: Our results showed an important increase (about 2-fold for 20 μM EGCG + 0.2 μM DOX and 2.5-fold for 50 μM EGCG + 0.2 μM DOX, p<0.05) in ZEB1 expression levels. In case of ABCB1 gene lack of influence on the mRNA level was observed (p>0.05). We also observed significant decrease of ZEB1 expression in MCF7 cells with 20 μM and 50 μM EGCG (p<0.05). In addition, EGCG (20 μM) caused an increase of MDM2 and PTEN mRNA levels in almost 100% (p<0.05) and 40% (p>0.05), respectively. Lack of the influence of EGCG was noted for the TWIST1 gene expression. In case of MCF7/DOX we showed an increase of mRNA level of PTEN gene about 50% (p<0.05).

Conclusions: These results suggest that EGCG may be potentially used in adjuvant therapy in the breast cancer treatment.
Febrile Syndrome in the Diabetic Adult, A Diagnostic Trap
Authors: Florentina-Mirela Stan , Benea Loredana , Forminte Marian , Vasilescu Razvan , Caraiola Simona 
Published: October 2018

Abstract

Introduction. Diabetes mellitus is one the most frequent pathologies that affect the general population in the modern era, infections being one of the main reasons why the diabetic patient will present to an emergency room. The diabetic patient can develop infections with various germs and locations, that have a tendency to reoccur and have an unfavourable evolution compared to the general population.

Case report. A 71 year old female patient, diabetic and with significant cardiovascular pathology is admitted with a persistent febrile syndrome after 7 days on antibiotic treatment for respiratory infection. She had recently had a neurosurgical evaluation for lumbar pain; radiology had shown a compression of the T12-L1 vertebral bodies, the neurosurgeon stating that surgery was not recommended because of the associated pathologies. Clinical examination reveals a poor general state, fever, pulmonary: bilateral basal subcrepitant rales, BP = 100/60 mmHg, AV = 100 BPM irregular. Blood work showed: leucocytosis with neutrophilia, inflammatory syndrome with high procalcitonin levels, hyperglycinaemia, nitrogen retention; chest X-ray shows stasis and the echocardiography EF 25%. The complete clinical examination detected a right inguinal abscess, that had a slow, favourable evolution after drainage and antibiotic therapy according to the antimicrobial susceptibility testing (AST) (blood culture with staph, wound culture with E.Coli). After 2 weeks, the antibiotic therapy was discontinued because of the favourable clinical and lab work evolution; after 24 hours the patient is febrile again, the leucocytosis and inflammatory syndrome reappear without any other clinical changes. The infectious assessment was redone: sterile wound cultures, sterile urine cultures, no valvular vegetation on echocardiography, a CT of the chest, abdomen and pelvic area suggestive for T12-L1 spondylodiscitis.

Conclusions. The etiological diagnosis of the febrile syndrome in a diabetic patient can be extremely difficult in practice. In our case, the patient had not noticed the inguinal abscess and the lumbar pain (that restrained her to bed) represented an important sign, easily ignored in the obvious infectious context.
Ultrasonographic changes in the liver tumors as indicators of adequate tumor coverage with electric field for effective electrochemotherapy
Authors: Boc Nina , Edhemovic Ibrahim , Kos Bor , Music Maja M. , Brecelj Erik , Trotovsek Blaz , Bosnjak Masa , Djokic Mihajlo , Miklavcic Damijan , Cemazar Maja , Sersa Gregor 
Published: October 2018

Abstract

Background
The aim of the study was to characterize ultrasonographic (US) findings during and after electrochem-otherapy of liver tumors to determine the actual ablation zone and to verify the coverage of the treated tumor with a sufficiently strong electric field for effective electrochemotherapy.

Patients and methods
US findings from two representative patients that describe immediate and delayed tumor changes after electrochemotherapy of colorectal liver metastases are presented.

Results
The US findings were interrelated with magnetic resonance imaging (MRI). Electrochemotherapy-treated tumors were exposed to electric pulses based on computational treatment planning. The US findings indicate immediate appearance of hyperechogenic microbubbles along the electrode tracks. Within minutes, the tumors became evenly hyperechogenic, and simultaneously, an oedematous rim was formed presenting as a hypoechogenic formation which persisted for several hours after treatment. The US findings overlapped with computed electric field distribution in the treated tissue, indicating adequate coverage of tumors with sufficiently strong electric field, which may predict an effective treatment outcome.

Conclusions
US provides a tool for assessment of appropriate electrode insertion for intraoperative electrochemo-therapy of liver tumors and assessment of the appropriate coverage of a tumor with a sufficiently strong electric field and can serve as predictor of the response of tumors.
Procedencia del recurso de queja en contra de ministros de Corte de Apelaciones que se pronunciaron respecto de otro recurso de queja: la "queja de queja"
Authors: Allende Pérez de Arce José Alberto 
Published: October 2018

El presente trabajo tiene por objeto abordar uno de los aspectos menos desarrollados del recurso de queja, que dice relación con la procedencia de su interposición ante la Corte Suprema, en contra de los ministros de Cortes de Apelaciones que pudieran haber incurrido en faltas o abusos graves al pronunciarse respecto de otro recurso de queja del cual les tocó conocer. Tal como se expondrá, existen distintas posturas al respecto, siendo múltiples los argumentos tanto a favor como en contra de su procedencia. No obstante, dicha divergencia de opiniones, en el último tiempo la Corte Suprema ha adoptado una postura constante en favor de la improcedencia de interponer el recurso de queja en contra de los ministros de Cortes de Apelaciones que fallaron un recurso de queja.
A Residency Professional Identity Curriculum and a Longitudinal Measure of Empathy
Authors: Crump William J. , Ziegler Craig H. , Fricker R. Steve 
Published: October 2018

BACKGROUND AND OBJECTIVES
Empathy measures were used before and after implementation of a structured professional identity curriculum to determine the effect among a group of family medicine residents.
METHODS
The Jefferson Scale of Empathy was completed by 18 residents at all three years of training before, immediately after a six month professional identity curriculum intervention, and six months after the curriculum was completed. The curriculum included one hour luncheon sessions on concepts of profession, burnout, and cynicism as well as thoughtful use of electronic medical records, prevention and management of burnout, mindfulness techniques and reflective writing and drawing. The Baptist Health Madisonville IRB approved the protocol as exempt and the authors have no conflicts of interests.
RESULTS
Similar to previous publications, a decline in empathy across the academic year was found, with a significant decline six months after the end of the curriculum. Residents who attended more sessions showed a non-significant smaller decline, and there were large standard deviations among each training level with some individual residents showing little change across the year. Evaluations of the curriculum were largely positive.
CONCLUSIONS
This professional identity curriculum in this group of residents may have temporarily mitigated the decline in measured empathy that has been described among residents. Results support some aspects of empathy as a trait in some residents rather than a state that is amenable to a training effect. Further study in this residency including longitudinal empathy measurements and focus groups is ongoing. Other programs’ experience with these issues is needed to add to sample size and diversity of training environments to discern which changes are significant and generalizable.
Динаміка ендотеліальної дисфункції після прямих методів реваскуляризації з приводу хронічної ішемії нижніх кінцівок
Authors: Rusyn V. I. , Korsak V. V. , Horlenko F. V. , Kenidra A. Yu. 
Published: October 2018

Мета. Вивчити динаміку ендотеліальної дисфункції у хворих з дистальними формами ураження артеріального русла до та після відновлення плину крові.
Матеріали і методи. Вивчено та проаналізовано результати комплексного обстеження 30 хворих, прооперованих у відділенні судинної хірургії Закарпатської обласної клінічної лікарні імені Андрія Новака з 2012 по 2018 р. з приводу хронічної ішемії нижніх кінцівок (НК): ІІБ ступінь ішемії був у 17 (56,7%) пацієнтів, ІІІА - у 13 (43,3%). Усім хворим виконано стегново-підколінне шунтування. У всіх хворих до та через 30 днів після оперативного втручання забирали венозну кров з подальшим визначенням кількості десквамованих ендотеліоцитів (ДЕТ), за якою судили про ступінь ендотеліальної дисфункції.
Результати. Зменшення кількості ДЕТ з (6,12 ± 0,21) до (3,9 ± 0,08) × 105 в 1 л плазми після виконання прямих методів реваскуляризації з приводу хронічної ішемії НК свідчить про достовірне зниження ступеня ендотеліальної дисфункцїї (р < 0,001).
Висновки. Переважання процесів регенерації над виявленням апоптозних ендотеліоцитів в інтимі судин та кількості ДЕТ свідчить про зниження ступеня ураження судин, позитивний динамічний ангіогенез та ефективність проведеного лікування.
Класифікація місцевих ускладнень гострого панкреатиту як підґрунтя для вибору оптимального методу їх хірургічної корекції
Authors: Andriushchenko V. V. , Andriushchenko D. V. , Mahlovanyi V. A. 
Published: October 2018

Мета. З’ясувати особливості місцевих укладнень (МУ) гострого панкреатиту (ГП), оцінивши їх топографо-анатомічні, патоморфологічні і кількісні характеристики, та опрацювати кваліфікаційну систематизацію МУ ГП.
Матеріали і методи. Проаналізовано результати лікування 460 хворих із МУ ГП при помірно тяжкому – 350 (76%) пацієнтів - і тяжкому – 110 (24%) пацієнтів -клінічному перебігу захворювання із застосуванням щодо МУ термінів «одиночні», «множинні» і «поєднані».
Результати. Одиночні МУ ГП виявлено у 285 (62%) хворих, переважно у сальниковій сумці (46%), паренхімі підшлункової залози (ПЗ) і заочеревинному просторі (33%). Множинні і поєднані МУ констатовано у 175 (38%) хворих, зокрема, множинні - у 42 (24%), поєднані – у 133 (76%). При тяжкому клінічному перебігу ГП домінували поєднані МУ – 41% спостережень порівняно з 25% спостережень при помірно тяжкому перебігу захворювання (χ2 = 6,564; р=0,01) та множинні - відповідно 18 і 7% спостережень (χ2 = 86,451; p < 0,0001). При помірно тяжкому перебігу ГП переважали одиночні МУ – 68% спостережень.
Висновки. МУ ГП вирізняються своїми топографо-анатомічними, патоморфологічними та кількісними характеристиками, а їх класифікація є основою для вибору методу хірургічної корекції.
Нові аспекти застосування глісонового методу мобілізації воріт печінки в хірургічному лікуванні метастатичного колоректального раку
Authors: Kolesnik O. O. , Burlaka A. A. 
Published: October 2018

Мета. Покращити безпосередні результати хірургічного лікування хворих із метастатичним колоректальним раком (мКРР) шляхом удосконалення Глісонового методу резекції печінки.
Матеріали і методи. Проведено ретроспективний аналіз (із січня 2014 по листопад 2017 р.) клінічних даних 62 хворих із МКРР, яким виконували мобілізацію воріт печінки Глісоновим методом.
Результати. Інтраопераційна крововтрата становила (382 ± 221) мл, тривалість резекції – (254 ± 63,7) хв, періопераційна гемотрансфузія – (380 ± 120) мл, теплова ішемія (селективний маневр Прінгла – СМП) – (25,1 ± 13,6) хв. Хірургічні ускладнення ІІІ і більше ступеня за класифікацією Clavien-Dindo зареєстровані у 5 (8,06%) хворих. Померлих не було.
Висновки. Оптимізація Глісонового методу мобілізації воріт печінки продемонструвала його доцільність та ефективність у хірургічному лікуванні МКРР. Основною перевагою цього методу вважаємо можливість визначення варіантної анатомії печінки, зменшення тривалості та об’єму теплової ішемії паренхіми.