bluuebunny/crossref_metadata_2025_split huggingface dataset:
The causal relationship between negative emotions and inflammatory dermatoses: a bidirectional Mendelian randomization study
Authors: Zhang Keyi , Zeng Mingwei , Lei Li , Fu Chuhan , Huang Jiangfeng , Zhou Shu , Wen Yaqing , Huang Jinhua , Chen Jing , Zeng Qinghai 
Published: December 2024

Abstract

Purpose
Observational studies have suggested a potential link between emotions and inflammatory dermatoses. However, research on the causal relationship between different types of emotions and inflammatory dermatoses is lacking. This study is aimed to investigate the causal relationship between negative emotions and inflammatory dermatoses through Mendelian randomization (MR) analysis.

Methods
Summary data of seven negative emotions were obtained from a genome-wide association study (GWAS) conducted by the MRC-IEU consortium. Seven inflammatory dermatoses including vitiligo, psoriasis, systemic lupus erythematosus, eczema, atopic dermatitis, acne, and rosacea were obtained from published GWAS. The MR analysis primarily employed the Inverse variance weighted (IVW) method, and supplemented by MR-Egger and other three MR methods.

Results
The IVW method revealed that guilty feelings have potential to increase the risk of psoriasis (OR = 1.02, 95% CI: 1.00–1.05, P = 0.019), while worrier/anxious feelings have a potential risk effect on eczema (OR = 1.07, 95% CI: 1.00–1.13, P = 0.042). Psoriasis could increase the occurrence of miserableness (OR = 1.41, 95% CI: 1.18–1.68, P = 0.0001), worrier/anxious feelings (OR = 1.26, 95% CI: 1.02–1.57, P = 0.033), nervous feelings (OR = 1.25, 95% CI: 1.05–1.49, P = 0.012), and loneliness/isolation (OR = 1.19, 95% CI: 1.04–1.36, P = 0.009). Eczema might cause an increased incidence of worrier/anxious feelings (OR = 1.038, 95% CI: 1.007–1.070, P = 0.014).

Conclusion
This MR study revealed bidirectional causality between worrier/anxious feelings and eczema. It also found that guilty feelings may elevate the risk of psoriasis, and individuals with psoriasis may experience increased rates of miserableness, worrier/anxious feelings, nervous feelings, and loneliness/isolation.
The Effects of Ankle and Foot Exercises on Ankle Strength, Balance, and Falls in Older People: A Systematic Review and Meta-Analysis
Authors: Liang Sam Guoshi , Chow Joman Chung Man , Leung Nga Ming , Mo Yee Nok , Ng Thomas Ming Hin , Woo Christy Lok Ching , Lam Freddy Man Hin 
Published: December 2024

Abstract

Objective
Ankle-foot control is essential to maintain balance and gait stability. However, there has been limited evidence on the effect of ankle-foot exercises on balance and falls in older people. This study aimed to summarize the effects of ankle-foot exercises on ankle flexibility and strength, balance, mobility, and falls in older people and to identify determining factors for ankle-foot exercises to improve balance and mobility.

Methods
Cumulative Index to Nursing and Allied Health Literature, Embase, PubMed, and Physiotherapy Evidence Database (PEDro) were searched to identify randomized controlled trials that studied the effects of ankle-foot exercises on ankle control, balance, and falls in older people. The PEDro scale was used to evaluate the methodological quality of the studies. Meta-analyses were done for similar outcomes. The quality of evidence was rated by GRADE.

Results
Sixteen papers (n = 651) were included. Meta-analyses showed that ankle-foot exercises significantly improved ankle plantarflexion strength (SMD = 0.35, 95% CI = 0.04 to 0.65, low-quality evidence), ankle flexibility (SMD = 0.48, 95% CI = −0.01 to 0.96, low-quality evidence), and balance in an eyes-open condition (SMD = 0.41, 95% CI = 0.19 to 0.70, low-quality evidence). There was no significant change in ankle dorsiflexion strength (SMD = 0.29, 95% CI = −0.24 to 0.82, very low-quality evidence), balance under eyes-closed condition (SMD = 0.41, 95% CI = −0.1 to 0.92, very low-quality evidence), and gait speed (SMD = 0.36, 95% CI = −0.24 to 0.96, very low-quality evidence). Two studies reported insignificant findings on fear of falling, fall incidence, and risk of falls.

Conclusions
Very low– to low-quality evidence showed that ankle-foot exercises effectively improve ankle plantarflexion strength, flexibility, and balance with eyes open, whereas no effect on falls was found. Improvements in balance and gait tend to be associated with improvements in ankle strength and flexibility. Toe-strengthening exercise and training 3 times per week appear to be important for improving balance.

Impact
This review suggested that ankle-foot exercises might improve balance in older people. Determining factors leading to improvement in balance and mobility were identified. It paves the ground for further research to study the effect of ankle-foot exercises on fall prevention.

Lay Summary
Ankle and foot exercises appear to be effective in improving ankle plantarflexion strength, flexibility, and balance performance in an eye-open condition. If you are an older adult who wants to improve your balance, your physical therapist may prescribe ankle and foot exercises as a supplemental component in a fall prevention program due to the observed improvements in balance and the safety and ease of the exercise.
Association of validated patient reported outcome measures with patients’ self-reported disease status in axial spondyloarthritis
Authors: Redeker Imke , Tsiami Styliani , Klavdianou Kalliopi , Oezdemir Yaren Elif , Sewerin Philipp , Kiefer David , Andreica Ioana , Kernder Anna , Vossen Diana , Kiltz Uta , Baraliakos Xenofon 
Published: December 2024

Abstract

Objective
In axSpA, validated PROs are well-established in clinical trials, but it remains unclear whether they comprehensively reflect patients’ discomfort and disease status. We aimed to investigate how patients’ self-reported disease status compares with validated clinical trial measures during routine clinical visits.

Methods
Data from axSpA patients’ initial and last five visits were retrospectively analysed. ASDAS, BASDAI, ASAS20, ASAS40 and ASAS partial remission were assessed at each visit and compared with patients’ self-reported disease status, categorized into very good (status satisfaction), mild, severe and very severe based on patients’ self-reported opinion on the level of severity of symptom burden related to axSpA. The association of these PROs with patients’ self-reported disease status was analysed using mixed models.

Results
A total of 3,120 visits over a median follow-up of 4.7 years from 557 axSpA patients were analyzed. Very good or mild self-reported disease status was reported in 98.7% of visits with inactive and 90.9% of visits with low ASDAS compared to 67.9% with high and 39.3% with very high ASDAS. Severe or very severe self-reported disease status was reported in 15.1% of visits with ASAS20 achievement, in 7.2% with ASAS40 achievement, and in 0.6% with achievement of ASAS partial remission, compared with 26.0% without ASAS20 achievement, 25.1% without ASAS40 achievement, and 30.1% without achievement of ASAS partial remission.

Conclusions
Patients’ self-reported disease status was well captured by ASDAS and BASDAI in most clinical visits. Other investigated measures used in clinical trials failed to capture patients’ self-reported disease status in a large proportion of visits.
Synovial transcriptome-wide association study implicates novel genes underlying rheumatoid arthritis risk
Authors: Hu Shou-Ye , Jiang Feng , Song Hui-Miao , Wang Ya-Kang , Tian Wen , Wu Hao , Yao Shi , He Chang-Yi , Gao Hui-Wu , Yang Tie-Lin , Yang Zhi , Guo Yan 
Published: December 2024

Abstract

Objectives
This study aimed to address the lack of gene expression regulation data in synovial tissues and to identify genes associated with rheumatoid arthritis (RA) in the synovium, a primary target tissue for RA.

Methods
Gene expression prediction models were built for synovial tissue using matched genotype and gene expression data from 202 subjects. Using this model, we conducted a transcriptome-wide association study (TWAS), utilizing the largest rheumatoid arthritis (RA) genome-wide association study (GWAS) meta-analysis data (n = 276 020). Further analyses, including conditional and joint analysis, causal analysis, differential expression analysis and gene-set enrichment analysis, were conducted to deepen our understanding of genetic architecture and comorbidity aetiology of RA.

Results
Our analysis identified eight genes associated with rheumatoid arthritis (RA), including three novel genes: TPRA1 (PTWAS = 9.59 × 10−6), HIP1 (PTWAS = 1.47 × 10−5) and RP11-73E17.2 (PTWAS = 3.32 × 10−7). These genes differed from those identified in previous TWAS studies using alternative tissues and may play a crucial role in the target synovial tissue. We found four genes exhibited significant causal relationships with RA and were differentially expressed in RA patients. Furthermore, we explored potential drug repurposing opportunities for these genes.

Conclusions
Our study is the first to model gene expression in synovial tissue, uncovering novel genetic determinants of rheumatoid arthritis (RA). This advancement not only deepens our understanding of RA's genetic architecture, but also offers promising avenues for targeted therapies and drug repurposing.
Effects of extremely low-frequency (50 Hz) electromagnetic fields on vital organs of adult Wistar rats and viability of mouse fibroblast cells
Authors: Tekam Chandra Kant Singh , Majumdar Shreyasi , Kumari Pooja , Prajapati Santosh Kumar , Sahi Ajay Kumar , Singh Richa , Krishnamurthy Sairam , Mahto Sanjeev Kumar 
Published: December 2024

Abstract
In recent years, scientific communities have been concerned about the potential health effects of periodic electromagnetic field exposure (≤1 h/d). The objective of our study is to determine the impact of extremely low-frequency pulsed electromagnetic fields (ELF-PEMF) (1–3 mT, 50 Hz) on mouse fibroblast (red fluorescent protein (RFP)-L929) cells and adult Wistar rats to gain a comprehensive understanding of biological effects. We observed that RFP-L929 exhibits no significant changes in cell proliferation and morphology but mild elevation in aspartate aminotransferases, alanine aminotransferases, total bilirubin, serum creatinine, and creatine kinase-myocardial band levels in ELF-PEMF exposed groups under in vitro and in vivo conditions. However, the histological examination showed no significant alterations in tissue structure and morphologies. Our result suggests that 50-Hz ELF-PEMF exposure (1–3 mT, 50 Hz) with duration (&lt;1 h/d) can trigger mild changes in biochemical parameters, but it is insufficient to induce any pathological alterations.
Altered neural response to social awkwardness in schizophrenia spectrum disorders
Authors: Przysinda Emily , Shovestul Bridget , Saxena Abhishek , Dong Xiaoyu , Reda Stephanie , Dudek Emily , Lamberti J. Steven , Lalor Edmund , Dodell-Feder David 
Published: December 2024

Abstract
Individuals with a schizophrenia spectrum disorder (SSD) have difficulties with social information processing, including mental state attribution, or “theory of mind” (ToM). Prior work has shown that these difficulties are related to disruption to the neural network subserving ToM. However, few such studies utilize naturalistic stimuli that are more representative of daily social interaction. Here, SSD and non-SSD individuals underwent fMRI while watching The Office to better understand how the ToM network responds to dynamic and complex social information, such as socially awkward moments. We find that medial prefrontal cortex tracks less with moment-to-moment awkwardness in SSD individuals. We also find a broad decrease in functional connectivity in the ToM network in SSD. Furthermore, neural response during awkward moments and functional connectivity was associated with psychotic experiences and social functioning. These results suggest that during naturalistic, socially awkward moments where mental state attribution is critical, individuals with SSD fail to recruit key regions of the ToM network, possibly contributing to decreased social understanding and impaired functioning.
P023 A Longitudinal Analysis of the Sleep Health of Neurodivergent and Neurotypical Children in Aotearoa
Authors: Dore L , Signal L , Muller D , Paine S , Fletcher B , Waldie K 
Published: December 2024

Abstract

Healthy sleep promotes physical, mental and neurobehavioural well-being, however it is widely acknowledged that neurodivergent children often experience sleep difficulties. We aimed to investigate the sleep health of neurodivergent (ND) children and neurotypical (NT) children in the Growing Up in New Zealand study over time.

Methods
Sleep duration, night wakings, and maternally reported sleep problems at 45-months, 2-years and 8-years were examined. Children were categorised into four groups based on Age-8 neurotype (ND/NT) and ethnicity (Māori/non-Māori) data and analysed using one-way ANOVA and chi square.

Results
Eight-year-old ND Māori had shorter average (mean [SD] hours) sleep (9.52 [1.30]) than NT non-Māori (9.76 [1.15], p=.016). At 2- and 8-years, a smaller proportion (% [95% CI]) of ND Māori (2-years 79.5% [72.6-85.2]; 8-years 77.0% [69.8-83.2]) and NT Māori (2-years 83.2% [80.6-85.6]; 8-years 80.0% [77.2-82.8]) had recommended sleep durations compared to NT non-Māori (2-years 87.2% [86.0-88.3]; 8- years 86.1% [84.9-87.3]). Similar patterns were observed for the other sleep measures, whereby a smaller proportion of ND children had an ‘appropriate’ number of night awakenings at 45-months and 8-years (Māori and non-Māori) compared to NT non-Māori. A larger proportion of ND children (Māori and non-Māori) had problematic sleep at 45-months and 8-years than NT children (Māori and non-Māori).
This study adds to our knowledge of differences in sleep between Māori and non-Māori children, and the timeframe for the emergence of differences in sleep between ND and NT children.
Prognostic factors of preterm neonates with gastrointestinal perforation: a retrospective cohort study from a tertiary neonatal center’s 13-year experience in China
Authors: Yuan Peng , Yao Huang , Feng Wei , Wang Yi 
Published: December 2024

Abstract
This study aimed to describe the clinical features of preterm neonatal gastrointestinal perforation (GIP) and evaluate the prognostic factors. This retrospective study comprised 191 preterm neonates diagnosed with GIP, who were categorized into survival and non-survival groups. Clinical and demographic data, laboratory and imaging features, and outcomes were retrospectively collected. Univariate and multivariate logistic regression analyses were conducted to identify independent prognostic factors. The median gestational age was 34 weeks, and the median birth weight was 2000 g. The overall mortality in the study cohort was 25.1%. The median age of onset of gastric perforation was 3 days (range: 1–11 days), while it was 7.5 days (range: 1–30 days) for intestinal perforation. Abdominal distension was the most common symptom in 184/191 (96.3%) subjects. Ninety-one (47.6%) neonates were diagnosed with a complication of necrotizing enterocolitis. Finally, three independent prognostic factors were identified: severe acidosis (OR: 7.604; 95% CI: 1.424–51.910; P = .025), shock (5.131; 2.419–11.266; P &lt; .001), and coagulopathy (3.269; 1.511–7.431; P = .003). Severe acidosis, shock, and coagulopathy are independent prognostic factors in preterm neonates with GIP. Indexes of systemic status evaluation should be given more attention when treating GIP in premature infants.
Prevalence and associated factors of anaemia and iron-deficiency anaemia among adolescent Sudanese schoolchildren: a cross-sectional study
Authors: Osman Hiba M , Osman Almarwa A , Al-Nafeesah Abdullah , AlEed Ashwaq , Adam Ishag 
Published: December 2024

Abstract
Anaemia among adolescents is a worldwide health problem; however, data on anaemia among adolescents in Sudan are scarce. A cross-sectional study was conducted to investigate the prevalence and associated factors of anaemia and iron-deficiency anaemia among adolescent schoolchildren in northern Sudan. Socio-demographic information was collected using a questionnaire. A total of 309 adolescents (52.4% female and 47.6% male) were enrolled in the study. Seventy-five (24.3%) adolescents had anaemia, and none had severe anaemia. In the multivariate analysis, history of pica [adjusted odds ratio (AOR)  =  2.30, 95% confidence interval (CI) = 1.31–4.02] was associated with increased odds of anaemia, and an increased level of serum ferritin (AOR  =  0.97, 95% CI = 0.95–0.99) was associated with decreased odds of anaemia. Of the adolescents, 189 (61.2%) and 55 (17.8%) had iron deficiency and iron-deficiency anaemia, respectively. In the multivariate analysis, being female (AOR  =  3.13, 95% CI = 1.88–5.23) and having a history of pica (AOR  =  1.85, 95% CI = 1.03–3.31) were associated with increased odds of iron deficiency. This study showed a high prevalence of anaemia and iron-deficiency anaemia among adolescents in this part of Sudan, which was associated with a history of pica.
Wilms tumor and associated predisposing syndromes and conditions
Authors: Meni David 
Published: December 2024

ABSTRACT
Wilms tumor, also known as nephroblastoma, is relatively rare but is the most common renal malignancy in children, accounting for about 5% of all childhood malignancies and 90% of all childhood renal malignancies. Advances in the understanding of the underlying cause and pathophysiology of Wilms tumor have significantly improved the prognosis and survival rates for children with Wilms tumor, but cases may occur sporadically and certain affected patients face higher rates of relapse and morbidity. The most common clinical presentation involves the identification of an abdominal mass or swelling without other signs or symptoms. The nonspecific nature of symptoms that can present can delay timely diagnosis and treatment. Numerous predisposing syndromes are associated with an increased risk for the development of Wilms tumor. Clinicians who recognize these syndromes and other conditions and understand the increased risk can provide the appropriate level of anticipatory guidance and use the optimal screening plan.
Developing a Nursing Workload Intensity Staffing Model
Authors: Bacon Cynthia Thornton , McCoy Thomas P. , Jenkins Marjorie , Gontarz JoAnna , Mittal Amita 
Published: December 2024

OBJECTIVE
To explore a workload intensity staffing (WIS) model's effect on nurse and patient outcomes.

BACKGROUND
Little is known about the relationship between WIS and nurse and patient outcomes.

METHODS
A point-based workload intensity tool was developed and implemented to determine the level of care for adult inpatients. Before and after implementation, nurses provided feedback on staffing practices. Rates for catheter-associated urinary tract infections (CAUTIs), central line–associated bloodstream infections (CLABSI), and patient fall rates were collected.

RESULTS
Nurses indicated that patients were equally distributed among nurses (pre-score mean [M] = 3.7 vs post M = 3.6, P = 0.609) and that patient work intensity was incorporated into patient assignments (pre M = 3.4 vs post M = 3.5, P = 0.717). A significant negative trend was revealed for patient falls per 1000 patient-days (b = −0.063, P = 0.010) with fewer falls post-WIS implementation and a significant decrease in falls with injury (b = −0.085, P = 0.002). There was no significant difference in CAUTI and CLABSI rates for pre- versus post-WIS and WIS implementation.

CONCLUSIONS
Although these initial results are promising, more research is needed on WIS and nurse and patient outcomes.
A new universal chimeric-antigen receptor (CAR)- fragment antibody binder (FAB) split system for cancer immunotherapy
Authors: Arina Ainhoa , Arauz Edwin , Warzecha Karolina , Masoumi Elham , Saaf Annika , Widło Łukasz , Slezak Tomasz , Zieminska Aleksandra , Dudek Karolina , Schaefer Zachary P. , Lecka Maria , Usatyuk Svitlana , Weichselbaum Ralph R. , Kossiakoff Anthony A. 
Published: December 2024

AbstractChimeric antigen receptor T (CAR-T) cell therapy has shown extraordinary results in treating hematological cancer. However, many patients relapse because of heterogeneous antigen expression and outgrowth of antigen lost variants. Other problems include on-target-off-tumor toxicity and the requirement for manufacturing of complex cellular products. Universal and modular CAR constructs offer significantly improved flexibility, safety and cost-effectiveness over conventional CAR constructs. Here we present a new chimeric-antigen receptor (CAR)-fragment antibody binder (Fab) platform based on an engineered protein G variant (GA1) and Fab scaffolds that present exquisite specificity and selectivity on antibody capture. The expression of GA1CAR on human CD8+T cells leads to antigen recognition and T cell effector function that can be modulated according to the affinity of the CAR for the Fab scaffold and of the Fab for the target. GA1CAR-T cells can recognize multiple Fab-antigen pairs on breast and ovarian cancer cell lines. Adoptive transfer of GA1CAR-T cells/Fabs in breast cancer xenograft models leads to effective tumor control. Rapid re-direction of the CAR-T cells to a new target can be achieved by using different Fabs. GA1CAR expression confers favorable phenotypic properties to T cells including a higher effector function upon exposure to antigen as compared to conventional scFv CAR-T cells. This highly versatile “plug and play” CAR-T platform has potential for application in personalized therapy, preventing antigen loss variant escape, decreasing toxicity and increasing access.
Improving design and normalization of multiplex proteomics study
Authors: Fang Huaying , Shih Mei-Chiung , Jiang Lihua , da Veiga Leprevost Felipe , Jian Ruiqi , Chan Joanne , Nesvizhskii Alexey I. , Snyder Michael P. , Tang Hua 
Published: December 2024

AbstractAdvances in multiplex mass spectrometry-based technologies have enabled high-throughput, quantitative proteome profiling of large cohort. However, certain experimental design configurations can amplify sample variability and introduce systematic biases. To address these challenges, we incorporated two novel features in a recent proteogenomic investigation: (1) the inclusion of two reference samples within each mass spectrometry run to serve as internal standards, and (2) the analysis of each specimen as technical replicates across two distinct mass spectrometry runs. Building on these enhancements, we present ProMix, a flexible analytical framework designed to fully leverage these supplementary experimental components. Using both simulated and real-world datasets, we demonstrate the improved performance of ProMix and highlight the advantages conferred by these refined experimental design strategies.