bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imperfect Linkage Disequilibrium Generates Phantom Epistasis (& Perils of Big Data)
Authors: de los Campos Gustavo , Sorensen Daniel Alberto , Toro Miguel Angel 
Published: March 2019

Abstract
The genetic architecture of complex human traits and diseases is affected by large number of possibly interacting genes, but detecting epistatic interactions can be challenging. In the last decade, several studies have alluded to problems that linkage disequilibrium can create when testing for epistatic interactions between DNA markers. However, these problems have not been formalized nor have their consequences been quantified in a precise manner. Here we use a conceptually simple three locus model involving a causal locus and two markers to show that imperfect LD can generate the illusion of epistasis, even when the underlying genetic architecture is purely additive. We describe necessary conditions for such “phantom epistasis” to emerge and quantify its relevance using simulations. Our empirical results demonstrate that phantom epistasis can be a very serious problem in GWAS studies (with rejection rates against the additive model greater than 0.28 for nominal p-values of 0.05, even when the model is purely additive). Some studies have sought to avoid this problem by only testing interactions between SNPs with R-sq. &lt;0.1. We show that this threshold is not appropriate and demonstrate that the magnitude of the problem is even greater with large sample size, intermediate allele frequencies, and when the causal locus explains a large amount of phenotypic variance. We conclude that caution must be exercised when interpreting GWAS results derived from very large data sets showing strong evidence in support of epistatic interactions between markers.
A jobb pitvari fülcse echokardiográfiás vizsgálata és annak klinikai jelentősége
Authors: Nemes Attila , Havasi Kálmán , Sághy László , Kohári Mária , Forster Tamás 
Published: March 2019

Abstract: In case of atrial fibrillation, there is a higher risk of thrombus formation, which could affect the right heart as well. Visualization of the right atrial appendage is difficult; the aim of the present review was to demonstrate the role of routine echocardiographic techniques and to show related clinical data. Orv Hetil. 2019; 160(12): 443–447.
Pszichoszomatikus tünetek előfordulási gyakorisága 8–17 éves magyar gyermekek körében
Authors: Fehér Piroska , Annár Dorina , Zsákai Annamária , Bodzsár Éva 
Published: March 2019

Abstract: Introduction: Subjective health complaints are common among children as well. Age, gender, health status, etc. can modify the prevalence, intensity, frequency and the dimensions of the psychosomatic complaints. Aim: The main purposes were to analyse the frequency pattern of psychosomatic complaints in children as well as to study the influence of physical status and lifestyle factors on psychosomatic status. Method: The subjects of the present analysis represented a random sample of the Hungarian National Growth Study (n = 13 331; 8–17-year-old). The three clusters of the health complaints were somatic, psychological and sleeping disorders. The psychosomatic status of 8–17-year-old children was analysed by dividing them into subgroups of experiencing the subjective health complaints often (weekly or more often), on an average level or rarely. Frequency distributions were examined for each subjective health complaint. Multinomial logistic regression analysis was applied to reveal the relationship between the frequency pattern of psychosomatic complaints and the hypothesized predictive factors. Results: The prevalence of the psychosomatic complaints increased by age, and girls reported more symptoms than boys. Subjective health status, nutritional status, body image, academic achievement, stature, body mass and socioeconomic status influenced the frequency pattern of psychosomatic complaints in girls, while physical activity, self-esteem, socioeconomic status and subjective health status in boys. Conclusions: Age, gender, socioeconomic status and psychosocial status can affect the frequency pattern of the psychosomatic complaints. Orv Hetil. 2019; 160(12): 464–472.
Pesquisa-ação na Superação de Dificuldades de Acompanhamento de Curso de Pós-graduação a “Lato Sensu” a Distância por Meio de Apoio da Tutoria
Authors: Shitsuka Ricardo , Shitsuka Dorlivete Moreira , Boghi Claudio 
Published: March 2019

Resumen
En la enseñanza regular, hay casos de estudiantes presentar algún grado de analfabetismo funcional en relación a la lectura. Hay también estudiantes que, después de concluir la graduación, ya no leen libros ni frecuentan cursos durante años. Actualmente, hay una gran cantidad de cursos de postgrado, y estos contribuyen trayendo de vuelta al graduado para el aula, la lectura y la actualización de contenidos, o incluso la inserción en nuevas tecnologías; sin embargo, no siempre todos acompañan y, en casos extremos, puede ocurrir la evasión escolar. El objetivo del presente estudio es presentar una investigación-acción en un foro de educación a distancia en la cual hay cambio de actitud de un alumno con dificultades en la participación forense por medio de la acción de la tutoría. Se realiza una investigación social, cualitativa, del fenómeno de la dificultad de aprendizaje de un alumno de curso de postgrado EaD con dificultades en la lectura de textos y elaboración de actividades y que, por medio del apoyo de la tutora, que actuó de forma dialógica , hizo la indicación de vídeos, enseñó el empleo de mapas conceptuales, de modo que el alumno logró superar las dificultades, evitando la evasión.

Palabras clave: Foro; Tecnologías Digitales de Información y Comunicación; aprendizaje; afecto; Motivación
Audiodescrição: Acessibilidade para Cursos EaD
Authors: Oliveira Brisa Teixeira de , Silva Andreza Regina Lopes da 
Published: March 2019

Considerando a importância dos recursos educacionais para a formação na modalidade a distância, questiona-se: Como torná-los acessíveis para pessoas com deficiência visual? Com base nessa problemática, o objetivo neste artigo é apresentar um conjunto de diretrizes para recursos educacionais comumente utilizados na modalidade a distância, de modo que estes sejam acessíveis às pessoas com deficiência visual. Para atender esse objetivo, os procedimentos metodológicos utilizados para esta pesquisa teórico-prática foi a busca exploratória e descritiva da literatura sob a abordagem qualitativa intersectada ao estudo de caso do Instituto de Pesquisa e Desenvolvimento Acadêmico Andreza Lopes. Como resultados, definiu-se um conjunto de diretrizes acessíveis, a partir do conceito e prática da audiodescrição, para orientar o desenvolvimento de diferentes recursos educacionais comumente utilizados em cursos EaD. Apesar de o resultado emergir de um estudo de caso, considera-se que tais diretrizes podem ser aplicadas a outras instituições, ampliando a oferta de cursos para pessoas com deficiência visual, potencializando o compromisso de incluir maior número de indivíduos que buscam o desenvolvimento continuado na sociedade atual, uma sociedade baseada no conhecimento.
Palavras chave: Educação a Distância. Acessibilidade. Inclusão. Audiodescrição.
Computadoras en la Educación: Problemas y Precauciones
Authors: Chadwick Clifton 
Published: March 2019

PortuguêsSão apresentadas duas grandes preocupações em relação ao uso de computadores em educação. A primeira é o baixo nível de processamento mental envolvido no uso de meios de massa. A segunda é a relação ecológica entre a pessoa e seu ambiente quando usando o computador, particularmente sob o ponto de vista de atribuição do controle. São dadas sugestões sobre como os professores podem resolver estes problemas. EnglishTwo principal worries are presented in relation to the use of computers in education. The first is the low level of mental processing involved in the use of mass media, a certain mindlessness. The second is the ecological relation between the person and his environment when using the computer, particularly the problem of external locus of control. Suggestions are made about how teachers may try to resolve these problems. EspanholSe presenta dos principales preocupaciones en relación con las computadoras y la educación. La primera es el bajo grado de procesamiento involucrado en el manejo de la información proveniente de los medios masivos. La segunda es la relación ecológica que se engendra entre la persona y su entorno cuando esta manejando la computadora, particularmente desde el punto de vista de atribución de control. Se ofrece sugerencias de cómo los profesores pueden resolver estos problemas.
Comunicação Estrutural: Uma Introdução
Authors: Romiszowski Alexander 
Published: March 2019

Material de Consulta (“Job-Aid”) baseado em textos originais de J.G. Bennett, A.M.Hodgson e K.Egan. A presente ajuda de trabalho é um pouco diferente da maioria das ajudas que foram publicadas nas edições anteriores da Revista. Na realidade é uma ajuda à compreensão de um conjunto específico de conceitos e princípios, ao invés de uma ajuda de execução de um conjunto específico de tarefas ou procedimentos. A primeira seção apresenta um resumo das orígens da metodologia de Comunicação Estrutural, dos seus princípios básicos como foram concebidos e apresentados em trabalhos originais de J.G. Bennett e A.M. Hodgson. A segunda seção apresenta uma amostra de uma unidade de estudo sobre Comunicação Estrutural, organizada segundo os princípios de design instrucional da Comunicação Estrutural. Esta “simulação” de uma experiência de aprendizagem foi adaptada de uma versão mais completa do exercício originalmente apresentada por K. Egan (1972) no seu livro, apropriadamente entitulado “Comunicação Estrutural”. Referências completas aos trabalhos citados são encontradas no artigo da autoria de Robinson Vida Noronha, também publicado nesta edição da Revista. O artigo examina a pesquisa sobre Comunicação Estruturada, e sua relevância no contexto de E-Learning.
Exploring the Impact of Individualized Research Consultations Using Pre and Posttesting in an Academic Library: A Mixed Methods Study
Authors: Sikora Lindsey , Fournier Karine , Rebner Jamie 
Published: March 2019

Abstract
Objective – Academic librarians consistently offer individualized help to students and researchers. Few studies have empirically examined the impact of individualized research consultations (IRCs). For many librarians, IRCs are an integral part of their teaching repertoire. However, without any evidence of an IRC’s effectiveness or value, one might ask if it’s worth investing so much time and effort. Our study explored the impact of IRCs on students' search techniques and self-perceived confidence levels. We attempted to answer the following questions: 1) Do IRCs improve students’ information searching techniques, including the proper use of keywords and/or subject headings, the accurate use of Boolean operators, and the appropriate selection of specialized resources/databases? 2) Do IRCs influence students’ confidence level in performing effective search strategies?
Methods – Our study used a mixed-methods approach. Our participants were students from the Faculties of Health Sciences and Medicine at the University of Ottawa, completing an undergraduate or graduate degree, and undertaking a research or thesis project. Participants were invited to complete two questionnaires, one before and one after meeting with a librarian. The questionnaires consisted of open-ended and multiple choice questions, which assessed students' search techniques, their self-perceived search techniques proficiency and their confidence level. A rubric was used to score students' open-ended questions, and self-reflective questions were coded and analyzed for content using the software QSR NVivo.
Results – Twenty-nine completed pre and posttests were gathered from February to September 2016. After coding the answers using the rubric, two paired-samples t-tests were conducted. The first t-test shows that students’ ability to use appropriate keywords was approaching statistical significance. The second t-test showed a statistically significant increase in students’ ability to use appropriate search strings from the pretest to the posttest. We performed a last paired-samples t-test to measure students’ confidence level before and after the appointment, and a statistically significant increase in confidence level was found.
Conclusion – Out of three paired t-tests performed, two showed a statistically significant difference from the pretest to the posttest, with one t-test approaching statistical significance. The analysis of our qualitative results also supports the statement that IRCs have a positive real impact on students’ search techniques and their confidence levels. Future research may explore specific techniques to improve search strategies across various disciplines, tips to improve confidence levels, and exploring the viewpoint of librarians.
DAKWAH AKOMODATIF: SOLUSI DAKWAH APLIKATIF FUNGSIONAL PADA MASYARAKAT MULTIKULTURAL
Authors: Fahrurrozi Fahrurrozi 
Published: March 2019

Da’wah in the reality of the society Indonesia multiple and plural gives a very wide space by The 1945 Constitution Article 29 paragraph 2 ensures the freedom of every citizen to embrace religion and trust and worship in accordance with his religion and his belief that. However, in practice, activities Da’wah in Indonesia still faces obstacles. Propagation is done by an individual or institutional basis, it still showed the selfishness and personal groups. With on behalf of truth and religion, their assault against another group or congregation. Problem calling other important enough is concerned the difference understand that often makes social relations with the dominant religion is compromised, even in certain levels could cause social insecurity. This article gives the concept of charity donations that is considered relevant to the context of the present model is the Da’wah accommodating, the focus was more on point accommodation to reality empirical sociological even theological society that multicultural. With this approach could be tested that Islam Rahman li al Alamein, and harmonization of the people in the midst of global challenges and technologies.
Peningkatan kapasitas manajemen usaha bagi pelaku usaha sektor industri UKM roti sebagai upaya peningkatan daya saing usaha menuju industri mandiri
Authors: Nasution Dewi Sartika 
Published: March 2019

[Bahasa]: Mayoritas masyarakat Babakan memiliki mata pencaharian sebagai pengusaha roti. Akan tetapi pengelolaan usaha roti masih sangat sederhana dan tidak dikelola dengan sistematis dan terencana dengan baik. Di sisi lain kunci utama keberhasilan dalam mengembangkan usaha adalah pada manajemen pengelolaan usaha. Kemampuan dalam manajemen usaha yang dimiliki produsen roti di Babakan tergolong kategori kurang. Mereka masih menjalankan usaha sebagai pekerjaan sampingan sebagai ibu rumah tangga. Mayoritas usaha roti belum memiliki ijin edar, kemasan roti yang digunakan masih sangat sederhana dan pemasaran juga masih dalam skala lokal atau hanya di pulau Lombok saja sedangkan potensi yang dimiliki para pengusaha roti sangat besar untuk dapat memasarkan rotinya hingga ke pulau lain. Pengabdian ini bertujuan untuk meningkatkan kemampuan manajemen usaha bagi para pelaku usaha industri kecil rumah tangga di kelurahan Babakan yang terdiri dari 25 produsen roti. Pelatihan dan pendampingan melibatkan dinas kesehatan, motivator dari area capacity to grow Bank BTPN, pemuka agama, dan UIN Mataram. Pelatihan dan pendampingan adalah berkaitan dengan cara pengurusan SPP-PIRT, manajemen keuangan usaha mikro, produk halal, dan cara berbisnis islami.
Kata Kunci: UMKM, PIRT, keuangan UMKM, produk halal, produsen, bisnis islami
[English]: The majority of the Babakan residents make a living as bread entrepreneurs. However, the management of bread business is still very simple and not managed systematically and well planned. On the other hand, the main key to success in developing a business is the ability of management. The ability in business management by bread producers in Babakan is categorized as low. They still run businesses as a side job. The majority of bread businesses do not yet have marketing licenses, bread packaging used is still very simple and marketing is also still on a local scale or only on the island of Lombok while the potential of bakers is very large to be able to market their bread to other islands. This community service program aims to improve business management ability for small-scale household industry in the Babakan sub-district consisting of 25 bread producers. Training and mentoring involved the health office, a motivator BTPN Banks, religious leaders, and UIN Mataram team. Training and mentoring are related to the way of arranging SPP-PIRT, micro business financial management, halal products, and ways of doing Islamic business.
Keywords: UMKM, PIRT, UMKM finance, halal products, producers and Islamic businesses
Upgrading sistem pengelolaan keuangan desa berbasis standar akuntansi keuangan (SAK) di Desa Nyurlembang Narmada Lombok Barat
Authors: Rosyidah Umu 
Published: March 2019

[Bahasa]: Pemerintah Desa sebagai pengelola dan pemangku kebijakan di desa harus dapat menyelenggarakan pengelolaan secara profesional, efektif, efisien, dan akuntabel. Pengelolaan juga harus didasarkan pada prinsip-prinsip manajemen publik yang baik agar terhindar dari tindakan yang kurang bermoral seperti penyimpangan, penggelapan, penyelewengan, dan tindakan korup lainnya. Pengelolaan keuangan meliputi kegiatan perencanaan, pelaksanaan, penatausahaan, pelaporan, dan pertanggungjawaban keuangan desa. Secara regulatif semua keuangan desa ini akan terdokumentasi dalam bentuk APBDes yang pengelolaannya mengikuti berbagai petunjuk peraturan perundang-undangan. Ini artinya, pemerintah desa tidak lagi sembarangan mengelola keuangan desa sekalipun otoritas sebagai kuasa pengguna anggaran dan pengguna anggaran ada pada seorang kepala desa. Pengabdian ini bertujuan untuk meningkatkan pengetahuan dan pelaksanaan pembinaan bagi kepala desa dan aparatnya sehingga dapat menambah referensi aparat tentang manajemen atau pengelolaan keuangan desa yang sesuai dengan peraturan yang berlaku yang berstandar akuntansi keuangan. Hasil pengabdian ini adalah pelatihan yang diberikan memberikan manfaat dan kontribusi bagi peningkatan pemahaman dan pengetahuan dalam manajemen pengelolaan dan pelaporan keuangan desa baik secara manual maupun dengan aplikasi TIK dengan aplikasi SIKUDes.
Kata Kunci: Sistem Pengelolaan Desa, Standar Akuntansi Keuangan (SAK), SisKeuDes
[English]: Administrative village as the manager and stakeholder in the village must be able to carry out management in a professional, effective, efficient and accountable manner. Management must also be based on the principles of good public management to avoid immoral actions such as irregularities, embezzlement, fraud, and other corrupt actions. Financial management includes activities in planning, implementing, administering, reporting, and responsible for village finance. Refering to the law, the finances will be documented in the form of APBDes whose management follows various legislative guidelines. This means that the village government is no longer carelessly managing village finance even though the authority as the power of budget users and budget users is with a village head. This community service program aims to increase the knowledge and implementation of guidance for the village head and his apparatus so that they can add apparatus references about village financial management or management in accordance with applicable regulations that have financial accounting standards. The result of this service is that the training provides benefits and contributes to the improvement of understanding and knowledge in village financial management and reporting management both manually and SIKUDes application.
Keywords: Village Management System, Financial Accounting Standards (SAK), SisKeuDes
Pemanfaatan media gambar berseri untuk memperkaya kemampuan menulis naratif bahasa inggris siswa kelas IX MTS NW Nurul Wathon Pengembur Lombok Tengah
Authors: Suhandra Ika Rama 
Published: March 2019

[Bahasa]: Penguasaan bahasa Inggris sebagai bahasa resmi internasional merupakan tuntutan bagi siswa agar mampu bersaing di era globalisasi. Masyarakat di daerah destinasi wisata seperti Lombok membutuhkan penguasaan Bahasa Inggris yang baik agar memudahkan mereka untuk mencari lapangan pekerjaan. Oleh karenanya siswa di sekolah harus mendapatkan pembelajaran Bahasa Inggris yang baik agar memiliki kompetensi yang memadai. Tujuan pengabdian ini adalah untuk meningkatkan kemampuan menulis narasi bahasa Inggris bagi siswa kelas IX melalui pemanfaatan gambar berseri. Metode pengabdian yang digunakan adalah dengan pengabdian tindakan kelas (PTK) dengan partisipan sebanyak 24 siswa kelas IX. Hasil pengabdian menunjukkan bahwa pemanfaatan media gambar berseri dalam pembelajaran bahasa Inggris dapat meningkatkan kemampuan menulis naratif dalam Bahasa Inggris.
Kata kunci: gambar berseri, bahasa Inggris, kemampuan menulis
[English]: Mastery of English as an official international language is a demand for students to be able to compete in the era of globalization. The residents in tourist destination areas such as Lombok need to master good English in order to be easier in finding jobs. Therefore students in schools must get good English learning in order to have adequate competence. The purpose of this community service activity is to improve the ability to write English narratives for students of class IX through the use of serial images. The method used was classroom action research with 24 students as participants in IX grade. The results show that the use of serial image media in learning English can improve the ability to write narratives in English.
Keywords: picture series, English, writing skill