bluuebunny/crossref_metadata_2025_split huggingface dataset:
PSI-5 Effects of fat-soluble vitamin injection on plasma and tissue vitamin concentrations in nursery pigs
Authors: Isensee Paige , Rotering Mikayla , Rinholen Kirsten , Kelley Paige , Boston-Denton Carli , Stuart Robert , Jang Young Dal 
Published: July 2019

Abstract
An experiment was conducted to investigate distribution of injected fat-soluble vitamins in plasma and tissue of nursery pigs. A total of 16 pigs were allotted to 2 treatments at d 7 post-weaning and fed a corn-soybean meal-based diet with no supplemental vitamin A. Treatments were control (no vitamins) and intramuscular injection with 3 mL VITAL E-A+D (STUARTPRODUCTS, Inc.) containing retinyl palmitate (RP; 300,000 IU), d-α-tocopherol (900 IU), and vitamin D3 (30,000 IU). All pigs were bled at d 0, 3, 7, and 14 post-injection and tissue samples were collected at d 7 and 14 post-injection (3 pigs/treatment). Data were analyzed by MIXED procedure of SAS. Plasma 25-hydroxycholecalciferol (3.44 vs. 71.00 ng/mL at d 3 post-injection) and retinol (0.09 vs. 0.18 µg/mL at d 3 post-injection) concentrations increased from d 3 to 14 post-injection (P < 0.05). Plasma RP was detected only in the vitamin treatment at d 3 and 7 post-injection (115.51 and 4.97 µg/mL, respectively). Liver retinol (0.63 vs. 19.10 µg/g at d 7 post-injection) and RP (43.33 vs. 199.13 µg/g at d 7 post-injection) concentrations increased at d 7 and 14 post-injection (P < 0.05) whereas those were not detected in the other tissues. The α-tocopherol concentrations increased in plasma (P < 0.05) at d 3 (0.99 vs. 17.14 µg/mL) and 7 post-injection and in liver (4.30 vs. 11.17 µg/g; P < 0.10), heart (4.60 vs. 24.80 µg/g; P < 0.10), and muscle (3.07 vs. 8.30 µg/g; P < 0.05) at d 7 post-injection. In conclusion, fat-soluble vitamin injection to nursery pigs increased plasma and liver status of α-tocopherol, retinol, and RP, and plasma 25-hydroxycholecalciferol concentrations. The α-tocopherol found in plasma post-injection was distributed to various tissues but RP only to the liver. Although plasma levels decreased post-injection, levels in liver increased for vitamins A and E, and vitamin E status was increased in all other tissues except brain.
Can Feeding of Silkworm on Different Mulberry Variety Affect Its Performance?
Authors: Khamenei-Tabrizi Ali Sadeghi , Sendi Jalal Jalali , Imaani Sohrab , Shojaee Mahmood 
Published: July 2019

AbstractThis study attempted to identify a suitable host plant for rearing hybrid 31*32 silkworms. Four varieties of mulberry leaves including Ichinose, Kenmochi, Kines, and local were supplied to hybrid 31*32 of silkworm and their performance was assessed. Variables measured included nutrition, biochemistry, and economic parameters of silkworm. Number of cocoons, individual and total cocoon weight, cocoon shell weight, and cocoon yield/10,000 per larvae were significantly greater on the Kines variety compared with the others. Similarly, nutritional indices including efficiency of conversion of ingested food (ECI), efficiency of conversion of digested food (ECD), relative growth rate (RGR), and consumption index (CI) were greater for the larvae fed on Kines. Digestive and antioxidant enzyme activity of the larvae differed with variety. Our results suggest that Kines could be considered as an appropriate host plant for rearing of silkworms based on the study parameters.
The eclipsing accreting white dwarf Z chameleontis as seen with TESS
Authors: Court J M C , Scaringi S , Rappaport S , Zhan Z , Littlefield C , Castro Segura N , Knigge C , Maccarone T , Kennedy M , Szkody P , Garnavich P 
Published: July 2019

ABSTRACT
We present results from a study of TESS observations of the eclipsing dwarf nova system Z Cha, covering both an outburst and a superoutburst. We discover that Z Cha undergoes hysteretic loops in eclipse depth – out-of-eclipse flux space in both the outburst and the superoutburst. The direction that these loops are executed in indicates that the disc size increases during an outburst before the mass transfer rate through the disc increases, placing constraints on the physics behind the triggering of outbursts and superoutbursts. By fitting the signature of the superhump period in a flux-phase diagram, we find the rate at which this period decreases in this system during a superoutburst for the first time. We find that the superhumps in this source skip evolutionary stage ‘A’ seen during most dwarf nova superoutbursts, even though this evolutionary stage has been seen during previous superoutbursts of the same object. Finally, O–C values of eclipses in our sample are used to calculate new ephemerides for the system, strengthening the case for a third body in Z Cha and placing new constraints on its orbit.
Classifying exoplanet candidates with convolutional neural networks: application to the Next Generation Transit Survey
Authors: Chaushev Alexander , Raynard Liam , Goad Michael R , Eigmüller Philipp , Armstrong David J , Briegal Joshua T , Burleigh Matthew R , Casewell Sarah L , Gill Samuel , Jenkins James S , Nielsen Louise D , Watson Christopher A , West Richard G , Wheatley Peter J , Udry Stéphane , Vines Jose I 
Published: July 2019

ABSTRACT
Vetting of exoplanet candidates in transit surveys is a manual process, which suffers from a large number of false positives and a lack of consistency. Previous work has shown that convolutional neural networks (CNN) provide an efficient solution to these problems. Here, we apply a CNN to classify planet candidates from the Next Generation Transit Survey (NGTS). For training data sets we compare both real data with injected planetary transits and fully simulated data, as well as how their different compositions affect network performance. We show that fewer hand labelled light curves can be utilized, while still achieving competitive results. With our best model, we achieve an area under the curve (AUC) score of $(95.6\pm {0.2}){{\ \rm per\ cent}}$ and an accuracy of $(88.5\pm {0.3}){{\ \rm per\ cent}}$ on our unseen test data, as well as $(76.5\pm {0.4}){{\ \rm per\ cent}}$ and $(74.6\pm {1.1}){{\ \rm per\ cent}}$ in comparison to our existing manual classifications. The neural network recovers 13 out of 14 confirmed planets observed by NGTS, with high probability. We use simulated data to show that the overall network performance is resilient to mislabelling of the training data set, a problem that might arise due to unidentified, low signal-to-noise transits. Using a CNN, the time required for vetting can be reduced by half, while still recovering the vast majority of manually flagged candidates. In addition, we identify many new candidates with high probabilities which were not flagged by human vetters.
The stellar initial mass function of the solar neighbourhood revealed by Gaia
Authors: Sollima A 
Published: July 2019

Abstract
I use a sample of more than 120 000 stars in the solar neighbourhood, with parallaxes, magnitudes and colours estimated with unprecedented accuracy by the second data release of the Gaia mission, to derive the initial mass function of the Galactic disc. A full-forward technique is used to take into account, for the population of unresolved binaries, the metallicity distribution and the star formation history, including their variation across the Galactic disc, as well as all the observational effects. The shape of the initial mass function is well represented by a segmented power law with two breaks at characteristic masses. It has a maximum at M ∼ 0.15 M⊙ with significant flattening (possibly a depletion) at lower masses and a slope of α = −1.34 ± 0.07 in the range 0.25 < M/M⊙ < 1. Above 1 M⊙, the initial mass function shows an abrupt decline with a slope ranging from α = −2.68 ± 0.09 to α = −2.41 ± 0.11, depending on the adopted resolution of the star formation history.
Is there a fundamental upper limit to the mass of a star cluster?
Authors: Norris Mark A , van de Ven Glenn , Kannappan Sheila J , Schinnerer Eva , Leaman Ryan 
Published: July 2019

Abstract
The discovery around the turn of the millennium of a population of very massive (M⋆ > 2 × 106 M⊙) compact stellar systems (CSS) with physical properties (radius, velocity dispersion, stellar mass etc.) that are intermediate between those of the classical globular cluster (GC) population and galaxies led to questions about their exact nature. Recently a consensus has emerged that these objects, usually called ultracompact dwarfs (UCDs), are a mass-dependent mixture of high-mass star clusters and remnant nuclei of tidally disrupted galaxies. The existence of genuine star clusters with stellar masses >107 M⊙ naturally leads to questions about the upper mass limit of the star cluster formation process. In this work we compile a comprehensive catalogue of CSS, and reinforce the evidence that the true ancient star cluster population has a maximum mass of M⋆ ∼ 5 × 107 M⊙, corresponding to a stellar mass at birth of close to 108 M⊙. We then discuss several physical and statistical mechanisms potentially responsible for creating this limiting mass.
Radio–optical galaxy shape and shear correlations in the COSMOS field using 3 GHz VLA observations
Authors: Hillier Tom , Brown Michael L , Harrison Ian , Whittaker Lee 
Published: July 2019

Abstract
We present a weak-lensing analysis of the 3 GHz Very Large Array radio survey of the COSMOS field, which we correlate with overlapping Hubble Space Telescope-Advanced Camera for Survey optical observations using both intrinsic galaxy shape and cosmic shear correlation statistics. After cross-matching sources between the two catalogues, we measure the correlations of galaxy position angles and find a Pearson correlation coefficient of 0.14 ± 0.03. This is a marked improvement from previous studies which found very weak, or non-existent correlations, and gives insight into the emission processes of radio and optical galaxies. We also extract power spectra of averaged galaxy ellipticities (the primary observable for cosmic shear) from the two catalogues, and produce optical–optical, radio–optical, and radio–radio spectra. The optical–optical autopower spectrum was measured to a detection significance of 9.80σ and is consistent with previous observations of the same field. For radio spectra (which we do not calibrate, given the unknown nature of their systematics), although we do not detect significant radio–optical (1.50σ) or radio–radio (1.45σ) E-mode power spectra, we do find the E-mode spectra to be more consistent with the shear signal expected from previous studies than with a null signal, and vice versa for B-mode and EB cross-correlation spectra. Our results give promise that future radio weak-lensing surveys with larger source number densities over larger areas will have the capability to measure significant weak-lensing signals.
Postsurgical Electrical Stimulation Enhances Recovery Following Surgery for Severe Cubital Tunnel Syndrome: A Double-Blind Randomized Controlled Trial
Authors: Power Hollie A , Morhart Michael J , Olson Jaret L , Chan K Ming 
Published: July 2019

Abstract

BACKGROUND
Patients with severe cubital tunnel syndrome often have poor functional recovery with conventional surgical treatment. Postsurgical electrical stimulation (PES) has been shown to enhance axonal regeneration in animal and human studies.

OBJECTIVE
To determine if PES following surgery for severe cubital tunnel syndrome would result in better outcomes compared to surgery alone.

METHODS
Patients with severe cubital tunnel syndrome in this randomized, double-blind, placebo-controlled trial were randomized in a 1:2 ratio to the control or stimulation groups. Control patients received cubital tunnel surgery and sham stimulation, whereas patients in the stimulation group received 1-h of 20 Hz PES following surgery. Patients were assessed by a blinded evaluator annually for 3 yr. The primary outcome was motor unit number estimation (MUNE) and secondary outcomes were grip and key pinch strength and McGowan grade and compound muscle action potential.

RESULTS
A total of 31 patients were enrolled: 11 received surgery alone and 20 received surgery and PES. Three years following surgery, MUNE was significantly higher in the PES group (176 ± 23, mean + SE) compared to controls (88 ± 11, P < .05). The mean gain in key pinch strength in the PES group was almost 3 times greater than in the controls (P < .05). Similarly, other functional and physiological outcomes showed significantly greater improvements in the PES group.

CONCLUSION
PES enhanced muscle reinnervation and functional recovery following surgery for severe cubital tunnel syndrome. It may be a clinically useful adjunct to surgery for severe ulnar neuropathy, in which functional recovery with conventional treatment is often suboptimal.
The Changing Confidence Relationship Between the UK Executive and Parliament in Comparative Context
Authors: Schleiter Petra , Evans Georgina 
Published: July 2019

Abstract
Executive–legislative relations in the UK are undergoing a process of transformation, and the confidence relationship is part of that change. The confidence relationship not only ensures that the executive is responsible to the legislature, but it also structures bargaining between government and the legislature via the parliament-initiated vote of no confidence and the executive-invoked vote of confidence. The Fixed-term Parliaments Act 2011 changes this relationship by removing from the prime minister the power to call an early election should confidence be lost, and by introducing one formal way of wording no-confidence and confidence motions. We place these changes in comparative context, showing that they strengthen parliament vis-à-vis the government, and discuss their implications against the background of contemporary constitutional practice in developed parliamentary democracies, medium-term electoral and political trends in the UK, and the 2019 Brexit deadlock.
Spatial links of phytoplankton abundance and community structure between shelf and slope waters off Oregon, USA
Authors: Du Xiuning , Peterson William 
Published: July 2019

Abstract
Coastal upwelling is known for inducing nearshore primary production, which can be advected to the offshore environment through offshore Ekman transport. However, this nearshore−offshore phytoplankton link has been less characterized at the community level. This study focuses on two shelf and slope sites off Oregon during years of 2013−2017 to examine the shelf−slope covariations in diatom and dinoflagellate abundance and community structure at seasonal and annual timescales. In general, the temporal changes of diatom and dinoflagellate abundance were coherent between shelf and slope. However, some differences were also noticeable. For example, diatom and dinoflagellate bloom magnitudes were higher in 2017 and 2014 on the shelf, but were higher in 2014−2016 at the slope. Diatom abundance had a stronger shelf−slope correlation than dinoflagellate correlation particularly in spring. The community structure was significantly correlated between shelf and slope during the annual upwelling period and in spring season. Ekman transport and nutrients played a significant role in shaping the diatom abundance and community structure temporal patterns at the slope. This shelf−slope correlation study infers that the benefits of nearshore upwelling blooms to the offshore food chains are season dependent and under high interannual variability.
The Historical Ontology of Art
Authors: De Clercq Rafael 
Published: July 2019

AbstractIn this article, I argue that our ontology of art has undergone a major change in the course of modern history. While we currently think of artworks as parts arranged in a certain way, there was a time when artworks were thought of as metaphysically more akin to ordinary artefacts such as tables and chairs; that is, as wholes having replaceable parts. This change in our ontology of art is reflected in our approach to art restoration. But what explains the change? I will suggest that the change took place because of a change in our conception of the function of art. More specifically, I will suggest that we have started to think of artworks as parts arranged in a certain way, because we have started to think of artworks as having, primarily, an aesthetic function.
Oxytocin Enhances an Amygdala Circuit Associated With Negative Symptoms in Schizophrenia: A Single-Dose, Placebo-Controlled, Crossover, Randomized Control Trial
Authors: Abram Samantha V , De Coster Lize , Roach Brian J , Mueller Bryon A , van Erp Theo G M , Calhoun Vince D , Preda Adrian , Lim Kelvin O , Turner Jessica A , Ford Judith M , Mathalon Daniel H , Woolley Joshua D 
Published: July 2019

AbstractNegative symptoms are core contributors to vocational and social deficits in schizophrenia (SZ). Available antipsychotic medications typically fail to reduce these symptoms. The neurohormone oxytocin (OT) is a promising treatment for negative symptoms, given its role in complex social behaviors mediated by the amygdala. In sample 1, we used a double-blind, placebo-controlled, crossover design to test the effects of a single dose of intranasal OT on amygdala resting-state functional connectivity (rsFC) in SZ (n = 22) and healthy controls (HC, n = 24) using a whole-brain corrected approach: we identified regions for which OT modulated SZ amygdala rsFC, assessed whether OT-modulated circuits were abnormal in SZ relative to HC on placebo, and evaluated whether connectivity on placebo and OT-induced connectivity changes correlated with baseline negative symptoms in SZ. Given our modest sample size, we used a second SZ (n = 183) and HC (n = 178) sample to replicate any symptom correlations. In sample 1, OT increased rsFC between the amygdala and left middle temporal gyrus, superior temporal sulcus, and angular gyrus (MTG/STS/AngG) in SZ compared to HC. Further, SZ had hypo-connectivity in this circuit compared to HC on placebo. More severe negative symptoms correlated with less amygdala-to-left-MTG/STS/AngG connectivity on placebo and with greater OT-induced connectivity increases. In sample 2, we replicated the correlation between amygdala-left-MTG/STS/AngG hypo-connectivity and negative symptoms, finding a specific association with expressive negative symptoms. These data suggest intranasal OT can normalize functional connectivity in an amygdala-to-left-MTG/STS/AngG circuit that contributes to negative symptoms in SZ.
Identification of subgroups of chemotherapy patients with distinct sleep disturbance profiles and associated co-occurring symptoms
Authors: Tejada Maria , Viele Carol , Kober Kord M , Cooper Bruce A , Paul Steven M , Dunn Laura B , Hammer Marilyn J , Wright Fay , Conley Yvette P , Levine Jon D , Miaskowski Christine 
Published: July 2019

AbstractStudy ObjectivesPurposes of this study were to identify subgroups of patients with distinct sleep disturbance profiles and to evaluate for differences in demographic, clinical, and various sleep characteristics, as well for differences in the severity of co-occurring symptoms among these subgroups.MethodsOutpatients with breast, gynecological, gastrointestinal, or lung cancer (n = 1331) completed questionnaires six times over two chemotherapy cycles. Self-reported sleep disturbance was evaluated using the General Sleep Disturbance Scale (GSDS). Latent profile analysis was used to identify distinct subgroups.ResultsThree latent classes with distinct sleep disturbance profiles were identified (Low [25.5%], High [50.8%], Very High [24.0%]) across the six assessments. Approximately 75% of the patients had a mean total GSDS score that was above the clinically meaningful cutoff score of at least 43 across all six assessments. Compared to the Low class, patients in High and Very High classes were significantly younger, had a lower functional status, had higher levels of comorbidity, and were more likely to be female, more likely to have childcare responsibilities, less likely to be employed, and less likely to have gastrointestinal cancer. For all of the GSDS subscale and total scores, significant differences among the latent classes followed the expected pattern (Low < High < Very High). For trait and state anxiety, depressive symptoms, morning and evening fatigue, decrements in attentional function, and decrements in morning and evening energy, significant differences among the latent classes followed the expected pattern (Low < High < Very High).ConclusionsClinicians need to perform in-depth assessments of sleep disturbance and co-occurring symptoms to identify high-risk patients and recommend appropriate interventions.
Engineered Cardiac Tissues Generated in the Biowire II: A Platform for Human-Based Drug Discovery
Authors: Feric Nicole T , Pallotta Isabella , Singh Rishabh , Bogdanowicz Danielle R , Gustilo Marietta M , Chaudhary Khuram W , Willette Robert N , Chendrimada Tim P , Xu Xiaoping , Graziano Michael P , Aschar-Sobbi Roozbeh 
Published: July 2019

AbstractRecent advances in techniques to differentiate human induced pluripotent stem cells (hiPSCs) hold the promise of an unlimited supply of human derived cardiac cells from both healthy and disease populations. That promise has been tempered by the observation that hiPSC-derived cardiomyocytes (hiPSC-CMs) typically retain a fetal-like phenotype, raising concern about the translatability of the in vitro data obtained to drug safety, discovery, and development studies. The Biowire II platform was used to generate 3D engineered cardiac tissues (ECTs) from hiPSC-CMs and cardiac fibroblasts. Long term electrical stimulation was employed to obtain ECTs that possess a phenotype like that of adult human myocardium including a lack of spontaneous beating, the presence of a positive force-frequency response from 1 to 4 Hz and prominent postrest potentiation. Pharmacology studies were performed in the ECTs to confirm the presence and functionality of pathways that modulate cardiac contractility in humans. Canonical responses were observed for compounds that act via the β-adrenergic/cAMP-mediated pathway, eg, isoproterenol and milrinone; the L-type calcium channel, eg, FPL64176 and nifedipine; and indirectly effect intracellular Ca2+ concentrations, eg, digoxin. Expected positive inotropic responses were observed for compounds that modulate proteins of the cardiac sarcomere, eg, omecamtiv mecarbil and levosimendan. ECTs generated in the Biowire II platform display adult-like properties and have canonical responses to cardiotherapeutic and cardiotoxic agents that affect contractility in humans via a variety of mechanisms. These data demonstrate that this human-based model can be used to assess the effects of novel compounds on contractility early in the drug discovery and development process.