bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supply chain issues in SME food sector: a systematic review
Authors: Jose Arun , Shanmugam PrasannaVenkatesan 
Published: September 2019

PurposeThe purpose of this paper is to investigate the significant supply chain issues in the small and medium-sized enterprise (SME) food industry. The objectives are to identify the major themes and the dynamic evolution of SME food supply chain (FSC) issues, the current research trends, the different modelling approaches used in SME FSC, and the most addressed SME food sector.Design/methodology/approachIn all, 3,733 published articles from 2002 to 2018 in the Clarivate Analytics Web of Science database were collected, from which 1,091 articles were shortlisted for the review. The authors used bibliographic coupling combined with co-word analysis to identify the historical relations of the research themes that emerged during the periods 2002–2014 and 2002–2018.FindingsThis research identified five major research themes such as production and distribution in alternative food networks, relationship, safety and standards in the FSC, greenhouse gas (GHG) emission impact of the farm food system, traceability and product quality in FSC and asymmetric price transmission in the FSC. Among the identified themes, GHG emission impact of the farm food system and traceability and product quality in the FSC have received increasing attention in recent years. The dairy sector is the most addressed sector (36 per cent), followed by fruits and vegetables (27 per cent), meat and poultry (18 per cent), seafood (10 per cent) and grains and oilseed (8 per cent). It is also identified that the dairy sector has received significant attention in the “GHG Emission impact of farm food system” theme. Similarly, meat and poultry sectors have received much attention in the “Traceability and product quality in the food supply chain” theme. Also, the authors identified that the empirical modelling approaches are the most commonly used solution methodology, followed by the conceptual/qualitative methods in the SME FSC.Originality/valueThis study maps and summarizes the existing knowledge base of supply chain issues in the SME food sector. The results of this review provide the major research areas, most commonly used approaches and food sectors addressed. This study also highlights the research gaps and potential future research direction.
Influence of eWOM information on consumers’ behavioral intentions in mobile social networks
Authors: Abedi Ehsan , Ghorbanzadeh Davood , Rahehagh Atena 
Published: September 2019

Purpose
Today, consumers play an active role in creating, generating and distributing the electronic word of mouth (eWOM) independent of marketers. Customer acquisition through referrals and word of mouth (WOM) has thus become an important goal for firms. In addition, mobile social networks have created valuable opportunities for eWOM. People are now able to discuss products and services of brands with their friends and acquaintances. The purpose of this paper is to examine the influence of eWOM information on consumers’ behavioral intentions in mobile social networks.

Design/methodology/approach
This study employed the information adoption model (IAM), theory of reasoned action and social exchange theory to investigate the influence of eWOM information on consumers’ behavioral intentions in mobile social networks. The study used 394 respondents to evaluate the proposed model using SmartPLS software.

Findings
Results show that the quality and credibility of eWOM information has a positive direct effect on perceived information usefulness. Attitude toward eWOM information mediates the influence of perceived information usefulness on information adoption. Also, attitude toward eWOM information has a significant positive influence on behavioral intentions, such as purchase intention and forwarding of eWOM information. However, information adoption does not have any significant relationship with the forwarding of eWOM information.

Research limitations/implications
This study seeks to address the dearth of research in the field of mobile social networks, especially regarding eWOM information. The study proposes a new model and empirically validates the hypothesized relationships. This research can serve as a stepping-stone for future research in this field.

Practical implications
This research is one of the first studies focusing on the influence of eWOM information, especially in mobile social networks. The research offers comprehensive and empirically validated factors pertaining to eWOM information in mobile social networks. The results of this study may be useful also for practitioners and managers of online companies.

Originality/value
A new eWOM IAM in mobile social networks is proposed based on information characteristics and consumer behavior. The model is validated afterward.
Growing entrepreneurial ecosystems
Authors: Bramwell Allison , Hepburn Nicola , Wolfe David A. 
Published: September 2019

PurposeThe purpose of this paper is to illustrate experimentation over time in Ontario, Canada with place-based innovation policies to support the development and coordination of entrepreneurial ecosystems on a regional basis across the province.Design/methodology/approachTracing the policy learning process and successive adaptations in program design over time, the authors provide a detailed case study of the evolution of the Ontario Network of Entrepreneurs (ONE) from 2003 to the present.FindingsThe authors find that the program has evolved in response to regular program reviews that include broad input from ecosystem actors operating at multiple levels within the network, and that intermediaries are key facilitators of inter- and intra-ecosystem linkages. However, program complexity and coordination challenges suggest that place-based innovation policies, such as the ONE, should focus specifically on innovation-intensive entrepreneurship.Research limitations/implicationsThese findings make three contributions to the theory and practice of place-based innovation policy. First, these policies are by nature experimental because they must be able to flexibly adapt according to policy learning and practitioner input from a wide variety of local contexts. Second, multilevel interactions between provincial policymakers and regional ecosystem actors indicate that place-based innovation policy is neither entirely driven by “top down” policy, nor “bottom up” networks but is rather a complex and variable “hybrid” blend of the two. Finally, publicly funded intermediaries perform essential inter- and intra-ecosystem connective functions but system fragmentation and “mission creep” remain enduring policy challenges.Originality/valueThe paper makes an original contribution to the literature by analyzing the development of entrepreneurial policy support framework and situating the case study in the context of the policy learning process involved in place-based innovation policymaking in North America.
Solving two-dimensional non-linear quadratic integral equations of fractional order via operational matrix method
Authors: Mirzaee Farshid , Alipour Sahar 
Published: September 2019

Purpose
The purpose of this paper is to develop a new method based on operational matrices of two-dimensional delta functions for solving two-dimensional nonlinear quadratic integral equations (2D-QIEs) of fractional order, numerically.

Design/methodology/approach
For this aim, two-dimensional delta functions are introduced, and their properties are expressed. Then, the fractional operational matrix of integration based on two-dimensional delta functions is calculated for the first time.

Findings
By applying the operational matrices, the main problem would be transformed into a nonlinear system of algebraic equations which can be solved by using Newton's iterative method. Also, a few results related to error estimate and convergence analysis of the proposed method are investigated.

Originality/value
Two numerical examples are presented to show the validity and applicability of the suggested approach. All of the numerical calculation is performed on a personal computer by running some codes written in MATLAB software.
Fabrication and characterization of TiO2 particulate filled agave Americana fiber-reinforced polyester resin composites
Authors: D. Vivekanandan , M. Sakthivel , S. Srinivasa Moorthy , S. Ajith Arul Daniel 
Published: September 2019

Purpose
In this study, TiO2 is used to enhance the mechanical properties of the composite material containing agave Americana fiber and polyester resin.

Design/methodology/approach
Agave Americana fiber was first treated with 5% of NaOH, and the composition of treated and untreated fiber was kept constant, whereas the particulate and resin were alternatively used. The handlay method is used to fabricate the composite plates. The morphology of the composites was studied using scanning electron microscopy (SEM).

Findings
The composite was composed of 30% treated agave Americana, 10% of TiO2 particulates and 60% of a polyester resin for better and enhanced mechanical properties.

Practical implications
The composite can be used for aero-structural components, automobile components and other areas where light-weight components are required.

Originality/value
A new type of agave Americana fiber with TiO2 and polyester resin composite was fabricated and investigated.
Characterization of Aroma‐Active Compounds, Phenolics, and Antioxidant Properties in Fresh and Fermented Capers (Capparis spinosa) by GC‐MS‐Olfactometry and LC‐DAD‐ESI‐MS/MS
Authors: Sonmezdag Ahmet Salih , Kelebek Hasim , Selli Serkan 
Published: September 2019

AbstractCaper (Capparis spinosa) is an important food ingredient whose fresh parts, particularly the flower buds, are consumed as a starter with olives, cheese, and nuts, or are used as a component in other foods. It is one of the most popular species of aromatic plants grown in the Mediterranean zone. Fermentation makes the caper edible and affects the overall aroma as well as sensory and nutritional characteristics. This study aimed to evaluate the changes in aroma, aroma‐active, and phenolic compounds of caper as affected by fermentation. Purge and trap method was used for the extraction of the aroma compounds, while gas chromatography‐mass spectrometry olfactometry and Liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry (LC‐DAD‐ESI‐MS/MS) were employed for the detection of aroma‐active compounds and phenolics, respectively. The results showed that the total amount of aroma compounds decreased drastically (62,616 to 21,471 µg/kg) in fermented sample. Twelve and 10 aroma‐active compounds were detected in fresh and fermented caper buds, respectively, for the first time by the application of aroma extract dilution analysis. Among these compounds, methyl isothiocyanate (flavor dilution [FD] factor = 512) in fresh caper and acetic acid (FD factor = 128) in the fermented caper had the highest FD factor. With regard to the phenolic compounds, a total of 16 components were identified in fresh and fermented capers. As observed in aroma compounds, the total phenolic concentration decreased as a result of fermentation. Two phenolic compounds being kaempferol‐3‐O‐glucosyl‐rhamnosyl‐glucoside and isorhamnetin hexoside were newly identified in caper.Practical ApplicationsCapparis spinosa is one of the most popular sources of different secondary metabolites of interest to consumers. The results of the present study showed that the fermentation process of the capers is highly influential on the neutral composition of the sample. The total concentrations of aroma and phenolic compounds were reduced by 66% and 78%, respectively, in response to fermentation process.
Alcohol control policy and changes in alcohol‐related traffic harm
Authors: Rehm Jürgen , Manthey Jakob , Lange Shannon , Badaras Robertas , Zurlyte Ingrida , Passmore Jonathon , Breda João , Ferreira‐Borges Carina , Štelemėkas Mindaugas 
Published: September 2019

AbstractAimsTo study the impact of alcohol control policy measures (i.e. increases in taxation, restrictions on availability, including minimum purchasing age regulations, legislation on drink driving and advertisement bans) on alcohol‐related traffic harm in Lithuania between January 2004 and February 2019.DesignAnalyses of trend data on the proportion of alcohol‐related collisions and crashes, injury and mortality, adjusting for secular trends, seasonality, periods of alcohol control measure implementation and economic development. Generalized additive mixed models were used. Multiple sensitivity analyses were conducted.SettingLithuania.CasesMonthly number of alcohol‐related cases of traffic collisions and crashes, injuries and deaths.Interventions and comparatorsPeriods of time during which new alcohol control measures were implemented and/or augmented compared to periods when they were not.MeasurementsMonthly data for 2004 to 2019 from routine statistics of the Lithuanian Road Police Service.FindingsAll indicators decreased consistently and significantly after the implementation of alcohol control measures, including increased taxation, reduction of availability and a ban on advertisement, starting in 2014. On average, each implemented policy measure permanently reduced the proportion of alcohol‐attributable crashes by 0.55% [95% confidence interval (CI) = 0.21–0.90%; P = 0.002], the proportion of alcohol‐attributable injuries by 0.60% (95% CI = 0.24–0.97%; P = 0.001) and the proportion of alcohol‐attributable deaths by 0.13% (95% CI = 0.10–0.15%; P < 0.001).ConclusionsAlcohol control policy measures, including measures to reduce overall level of alcohol consumption, were associated with a marked decrease in alcohol‐related traffic harm.
Analysis of testosterone pathway genes in dogs (78,XY;SRY‐positive) with ambiguous external genitalia revealed a homozygous animal for 2‐bp deletion causing premature stop codon in HSD17B3
Authors: Krzeminska P. , Nizanski W. , Nowacka‐Woszuk J. , Switonski M. 
Published: September 2019

SummaryThe genetic background of disorders of sex development (DSD) in dogs with a normal male sex chromosome set (78,XY) is poorly described. In this study, we present for the first time, an analysis of six genes of the testosterone pathway, encoding enzymes (CYP17A1, HSD3B2, HSD17B3, SRD5A2) and transcription factors (NR5A1, AR). The entire coding sequence and flanking regions of the introns, 5′‐UTR and 3′‐UTR were analyzed in five DSD dogs (78,XY, SRY‐positive) with ambiguous external genitalia and in 15 control dogs. A homozygous deletion of 2 bp in exon 2 of HSD17B3 (hydroxysteroid 17‐beta dehydrogenase 3) was found in a Dachshund dog with enlarged clitoris, vulva and abdominal gonads and decreased serum testosterone level. In silico analysis revealed that this deleterious variant causes truncation of the encoded polypeptide (from 306 to 65 amino acids) and deprivation of the active site of the encoded enzyme. Genotyping of 23 control Dachshund dogs showed a normal homozygous genotype. Thus, we assumed that the 2‐bp deletion is the causative variant. Moreover, 24 SNPs (four in CYP17A1, three in HSD3B2, six in HSD17B3, five in SRD5A2, one in AR and five in NR5A1), two intronic indels (one in HSD3B2 and one in SRD5A2) and two microsatellite polymorphisms in exon 1 of AR were found. Six SNPs appeared to be novel. No association with DSD phenotype was observed. Identification of the first case of DSD in domestic animals caused by a deleterious variant of a gene involved in testosterone synthesis showed that these genes are important candidates in such studies.
Characteristics, aetiologies and trends of hepatocellular carcinoma in patients without cirrhosis: a United States multicentre study
Authors: Gawrieh Samer , Dakhoul Lara , Miller Ethan , Scanga Andrew , deLemos Andrew , Kettler Carla , Burney Heather , Liu Hao , Abu‐Sbeih Hamzah , Chalasani Naga , Wattacheril Julia 
Published: September 2019

SummaryBackgroundLimited data exist on the burden and features of non‐cirrhotic hepatocellular carcinoma (HCC) in the United States.AimTo evaluate characteristics, aetiologies, trends and outcomes of non‐cirrhotic HCC from 2000 to 2014 at five large US centresMethodsPatient, tumour and liver disease aetiology data were collected. The presence of underlying cirrhosis was assessed based on published criteria.ResultsOf 5144 eligible patients with HCC, 11.7% had no underlying cirrhosis. Non‐cirrhotic patients were older (64.1 vs 61.2 years), more frequently females (33.9% vs 20.8%) and less frequently black (8.3% vs 12.4%) (P < .001 for all). Among non‐cirrhotic patients, non‐alcoholic fatty liver disease (NAFLD) was the most common liver disease (26.3%), followed by hepatitis C virus (HCV) (12.1%) and hepatitis B virus (HBV) (10%) infections. As of 2014, there was increased percentage of cirrhotic HCC and a decline in non‐cirrhotic HCC mainly due to significant annual increases in cirrhotic HCC due to HCV (0.96% [P < .0001]) and NAFLD (0.66% [P = .003]). Patients with non‐cirrhotic HCC had larger tumours (8.9 vs 5.3 cm), were less frequently within Milan criteria (15% vs 39%), more frequently underwent resection (43.6% vs 8%) (P < .001 for all) and had better overall survival than cirrhotic HCC patients (median 1.8 vs 1.3 years, P = .004).ConclusionsNearly 12% of HCCs occurred in patients without underlying cirrhosis. NAFLD was the most common liver disease in these patients. During the study, the frequency of non‐cirrhotic HCC decreased, whereas that of cirrhotic HCC increased. Although non‐cirrhotic patients presented with more advanced HCC, their survival was better.
Bronchodilation induced by PGE2 is impaired in Group III pulmonary hypertension
Authors: Ozen Gulsev , Benyahia Chabha , Mani Salma , Boukais Kamel , Silverstein Adam M. , Bayles Richard , Nelsen Andrew C. , Castier Yves , Danel Claire , Mal Hervé , Clapp Lucie H. , Longrois Dan , Norel Xavier 
Published: September 2019

Background and PurposeIn patients with pulmonary hypertension (PH) associated with lung disease and/or hypoxia (Group III), decreased pulmonary vascular tone and tissue hypoxia is therapeutically beneficial. PGE2 and PGI2 induce potent relaxation of human bronchi from non‐PH (control) patients via EP4 and IP receptors, respectively. However, the effects of PGE2/PGI2 and their mimetics on human bronchi from PH patients are unknown. Here, we have compared relaxant effects of several PGI2–mimetics approved for treating PH Group I with several PGE2–mimetics, in bronchial preparations derived from PH Group III and control patients.Experimental ApproachRelaxation of bronchial muscle was assessed in samples isolated from control and PH Group III patients. Expression of prostanoid receptors was analysed by western blot and real‐time PCR, and endogenous PGE2, PGI2, and cAMP levels were determined by ELISA.Key ResultsMaximal relaxations induced by different EP4 receptor agonists (PGE2, L‐902688, and ONO‐AE1‐329) were decreased in human bronchi from PH patients, compared with controls. However, maximal relaxations produced by PGI2–mimetics (iloprost, treprostinil, and beraprost) were similar for both groups of patients. Both EP4 and IP receptor protein and mRNA expressions were significantly lower in human bronchi from PH patients. cAMP levels significantly correlated with PGI2 but not with PGE2 levels.Conclusion and ImplicationsThe PGI2–mimetics retained maximal bronchodilation in PH Group III patients, whereas bronchodilation induced by EP4 receptor agonists was decreased. Restoration of EP4 receptor expression in airways of PH Group III patients with respiratory diseases could bring additional therapeutic benefit.
Burden of dental caries and periodontal disease in South Korea: An analysis using the national health insurance claims database
Authors: Radnaabaatar Munkhzul , Kim Young‐Eun , Go Dun‐Sol , Jung Yunsun , Jung Jaehun , Yoon Seok‐Jun 
Published: September 2019

AbstractObjectivesIt is essential to measure and monitor the burden of dental caries and periodontal disease (PD) in Korea's ageing population due to their potential impact on morbidity, quality of life and economic condition. This study aimed to quantify the size of burden of dental caries and PD using the disability‐adjusted life years (DALYs), and their trends.MethodsDALYs were estimated using incidence‐based approaches to calculate the burden of dental caries and PD from 2013 to 2015 in Korea. Incidence and prevalence were estimated using medical claim data by specific algorithms. Additionally, sensitivity analysis was conducted to investigate possible weakness in the study methodology. To conduct the sensitivity analysis, we modified the algorithms to estimate prevalence and incidence.ResultsThe burden of dental caries and PD increased by 39.2% and 57.0%, respectively, between 2013 and 2015. In 2015, dental caries and PD ranked 11th and 25th, respectively, in terms of the leading causes of DALYs. The burden of dental caries was the most substantial in children aged 0‐9 years, while that of PD was the most substantial among those in their ages of 40 and 50 (per 100 000 population). After sensitivity analysis with a modified disease algorithm, the magnitude of disease burden changed considerably.ConclusionsDental caries and PD constitute substantial burdens in South Korea. Despite the known limitations, medical claims data can be a powerful resource for conducting timely and cost‐effective measurements of oral health. In countries, where universal dental schemes are available, there is need to estimate the burden of oral disease using claims data, for methodical advances in the research field.
Current climate, isolation and history drive global patterns of tree phylogenetic endemism
Authors: Sandel Brody , Weigelt Patrick , Kreft Holger , Keppel Gunnar , van der Sande Masha T. , Levin Sam , Smith Stephen , Craven Dylan , Knight Tiffany M. 
Published: September 2019

AbstractAimWe mapped global patterns of tree phylogenetic endemism (PE) to identify hotspots and test hypotheses about possible drivers. Specifically, we tested hypotheses related to current climate, geographical characteristics and historical conditions and assessed their relative importance in shaping PE patterns.LocationGlobal.Time periodWe used the present distribution of trees, and predictors covering conditions from the mid‐Miocene to present.Major taxa studiedAll seed‐bearing trees.MethodsWe compiled distributions for 58,542 tree species across 463 regions worldwide, matched these to a recent phylogeny of seed plants and calculated PE for each region. We used a suite of predictor variables describing current climate (e.g., mean annual temperature), geographical characteristics (e.g., isolation) and historical conditions (e.g., tree cover at the Last Glacial Maximum) in a spatial regression model to explain variation in PE.ResultsTree PE was highest on islands, and was higher closer to the equator. All three groups of predictor variables contributed substantially to the PE pattern. Isolation and topographic heterogeneity promoted high PE, as did high current tree cover. Among mainland regions, temperature seasonality was strongly negatively related to PE, while mean annual temperature was positively related to PE on islands. Some relationships differed among the major floristic regions. For example, tree cover at the Last Glacial Maximum was a positive predictor of PE in the Palaeotropics, while tree cover at the Miocene was a negative predictor of PE in the Neotropics.Main conclusionsGlobally, PE can be explained by a combination of geographical, historical and current factors. Some geographical variables appear to be key predictors of PE. However, the impact of historic and current climate variables differs considerably among the major floristic regions, reflecting their unique histories. Hence, the current distribution of trees is the result of globally relevant geographical drivers and regional climatic histories.