bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study
Authors: Melcangi Roberto Cosimo , Casarini Livio , Marino Marco , Santi Daniele , Sperduti Samantha , Giatti Silvia , Diviccaro Silvia , Grimoldi Maria , Caruso Donatella , Cavaletti Guido , Simoni Manuela 
Published: July 2019

Context
Post-finasteride syndrome (PFS) occurs in patients with androgenic alopecia after suspension of the finasteride treatment, leading to a large variety of persistent side effects. Despite the severity of the clinical picture, the mechanism underlying the PFS symptoms onset and persistence is still unclear.

Objective
To study whether epigenetic modifications occur in PFS patients.

Methods
Retrospective analysis of a multicentric, prospective, longitudinal, case–control clinical trial, enrolling 16 PFS patients, compared to 20 age-matched healthy men. Main outcomes were methylation pattern of SRD5A1 and SRD5A2 promoters and concentration of 11 neuroactive steroids, measured by liquid chromatography-tandem mass spectrometry, in blood and cerebrospinal fluid (CSF) samples.

Results
SRD5A1 and SRD5A2 methylation analysis was performed in all blood samples (n = 16 PFS patients and n = 20 controls), in 16 CSF samples from PFS patients and in 13 CSF samples from controls. The SRD5A2 promoter was more frequently methylated in CSF of PFS patients compared to controls (56.3 vs 7.7%). No promoter methylation was detected in blood samples in both groups. No methylation occurred in the SRD5A1 promoter of both groups. Unmethylated controls compared to unmethylated SRD5A2 patients showed higher pregnenolone, dihydrotestosterone and dihydroprogesterone, together with lower testosterone CSF levels. Andrological and neurological assessments did not differ between methylated and unmethylated subjects.

Conclusions
For the first time, we demonstrate a tissue-specific methylation pattern of SRD5A2 promoter in PFS patients. Although we cannot conclude whether this pattern is prenatally established or induced by finasteride treatment, it could represent an important mechanism of neuroactive steroid levels and behavioural disturbances previously described in PFS.
Effect of acidic environment and intracanal medicament on push-out bond strength of biodentine and mineral trioxide aggregate plus: an in vitro study
Authors: Jain Priyanka , Nanda Zinnie , Deore Rahul , Gandhi Amit 
Published: July 2019

Introduction. This in-vitro study aims to evaluate the effect of acidic environment and intracanal medicament on push out bond strength of Biodentine and Mineral Trioxide Aggregate Plus (MTA Plus)
Method. Forty extracted single rooted teeth were sectioned below the cement-enamel junction. The root canals were instrumented using rotary files and then peeso reamer was used to obtain standardized root canal dimension. Specimens were randomly classified into following groups- Group 1: calcium hydroxide in the absence of acidic environment; Group 2: calcium hydroxide in the presence of acidic environment; Group 3: no intracanal medicament in the absence of acidic environment; Group 4: no intracanal medicament in the presence of acidic environment. Specimens were kept for 7 days at room temperature. Thereafter, specimens of each group were transversely sectioned into 1 mm thick slices and divided into 2 sub-groups according to the use of biodentine and MTA Plus. Using Universal Testing Machine, push out bond strength test was carried out and the data were analyzed statistically.
Results. There was no statistically significant difference in the bond strength of biodentine and MTA Plus (P>0.05). For both MTA Plus and biodentine, with or without calcium hydroxide, the push out bond strength was less in acidic environment and this difference was more pronounced without calcium hydroxide. In all the four groups, MTA plus showed comparable bond strength to biodentine.
Conclusion. MTA Plus is a viable option for apexification. The push out bond strength of Biodentine and MTA Plus is impaired by acidic environment. Prior application of calcium hydroxide slightly increased the bond strength, though the difference was statistically insignificant.
Comparing patient safety culture in Bulgarian, Croatian and American hospitals – preliminary results
Authors: Stoyanova Rumyana , Dimova Rositsa , Tarnovska Miglena , Boeva Tatyana , Dimov Rosen , Doykov Ilian 
Published: July 2019

Background and aims. Patient safety culture (PSC) is an essential component of the quality of healthcare. Improving PSC is considered a priority in many developed countries. A specialized software platform for registration and evaluation of hospital patient safety culture has been developed with the support of the Medical University Plovdiv Project №11/2017.
The aim of the study is to assess the status of PSC in Bulgarian hospitals and to compare it to that in USA and Croatian hospitals.
Methods. The study was conducted from June 01 to July 31, 2018 using the web-based Bulgarian Version of the Hospital Survey on Patient Safety Culture Questionnaire (B-HSOPSC). Two hundred and forty-eight medical professionals from different hospitals in Bulgaria participated in the study. In order to quantify the differences of positive scores distributions for each of the 42 HSOPSC items between Bulgarian, Croatian and USA samples, the χ2-test was applied. The research hypothesis assumed that there were no significant differences between the Bulgarian, Croatian and US PSCs.
Results. The results revealed 14 significant differences in the positive scores between the Bulgarian and Croatian PSCs and 15 between the Bulgarian and the USA PSC, respectively. Bulgarian medical professionals provided less positive responses to 12 items compared with Croatian and USA respondents. The Bulgarian respondents were more positive compared to Croatians on the feedback and communication of medical errors (Items - C1, C4, C5) as well as on the employment of locum staff (A7) and the frequency of reported mistakes (D1). Bulgarian medical professionals were more positive compared with their USA colleagues on the communication of information at shift handover and across hospital units (F5, F7). The distribution of positive scores on items: “Staff worry that their mistakes are kept in their personnel file” (RA16), “Things ‘fall between the cracks’ when transferring patients from one unit to another” (RF3) and “Shift handovers are problematic for patients in this hospital” (RF11) were significantly higher among Bulgarian respondents compared with Croatian and US respondents.
Conclusions. Significant differences of positive scores distribution were found between Bulgarian and USA PSC on one hand and between Bulgarian and Croatian on the other. The study reveals that distribution of positive responses could be explained by the cultural, organizational and healthcare system differences.
Advanced glycation end products in isoproterenol-induced acute myocardial infarction
Authors: Timercan Tatiana , Șveț Inna , Pantea Valeriana , Ambros Ala , Lîsîi Leonid 
Published: July 2019

Background. Isoproterenol is a synthetic catecholamine that can produce diffuse myocardial necrosis at high doses. Advanced glycation end products (AGEs) are involved in the development and progression of cardiovascular disease, including acute coronary syndrome. The purpose of the study was to determine the changes of serum and tissue AGE content in isoproterenol-induced acute myocardial infarction and to assess their informational character in the early diagnosis, risk stratification and prognosis of disease.
Methods. Forty adult male rats were divided into 5 groups: sham (L1=11), control 0.9% NaCl (L2=11), and with experimental myocardial infarction (L3=6, L4=6; L5=6), induced by the subcutaneous injection of Isoproterenol Hydrochloride solution 100 mg/kg, and sacrificed over 6 hours, 24 hours and 7 days post infarction. The results were presented by median and interquartile range. The groups were compared using Kruskal-Wallis and Mann-Whitney nonparametric tests, and the Spearman correlation coefficient was calculated (SPSS 23.0).
Results. A decrease of AGE serum levels in L3 were identified, followed by a significant increase in L4, the trend maintained in L5, which significantly exceeded the values in sham and control groups. In the homogenate, AGEs presented an elevation in L3, with a relevant decrease in L4, and an inconsistent increase in L5 compared to sham and control groups.
Conclusion. The collected data suggest the utility of AGE assessment in early diagnosis and risk stratification in acute myocardial infarction.
Preclinical dosimetric evaluation of Ixolaris labeled with 99mTc and Translacional Model
Authors: Soriano Figueiredo Sarah , Lopes Sérgio , Barboza Thiago , De Sá Lidia 
Published: July 2019

ABSTRACT This study aimed to determine the biokinetic model for Ixolaris labelled with 99mTc radiotracer in mice by means of an imaging dosimetry method to estimate the absorbed and effective doses resulting from the diagnosis of melanoma and metastases in humans. C57BL6 mice induced animals with cell line B16-F10 murine melanoma were tested. It was determined by Single Photon Emission Tomography Computed (SPECT) images a latency period of 15 to 21 days for the development of lung metastasis in mice. The 99mTc-Ixolaris radiopharmaceutical was intravenously administered in a caudal vein, and SPECT images were acquired approximately at 0.5 h, 1.5 h, 2.5 h, 3.5 h and 24 h post-administration for analysis and biodistribution quantification. The biokinetic model was determined and cumulative activity to estimate the absorbed dose in each organ was calculated. The mass and metabolic differences between mice and humans were considered and used to extrapolate the data for different scales. Absorbed doses in irradiated target organs were calculated for the source organs based on dose factors provided by the software MIRDOSE and Olinda/EXM (S factor). Afterwards, the effective doses were estimated. The metabolic differences were 7,02 in this study. The dosimetric results indicated an estimated effective dose of 4.3 mSv for diagnostic exams conducted in human melanoma patients for an administered activity of 25.7 MBq. Comparing with effective doses resulting from other 99mTc diagnostic techniques, effective dose ranging from 0.6 to 4.8 mSv it was concluded that the procedure should proceed into a Clinical Phase in humans.
Legalizing Unofficial (Sirri) Marriage For Indonesian Migrant Workers In Malaysia
Authors: Faizin Afwan , Alfitra Alfitra , Mansur Ali 
Published: July 2019

Abstracts:In recent decades, there has been a massive influx of Indonesian migrant workers or TKI (Tenaga Kerja Indonesia) in Malaysia, both legally and illegally. Unfortunately, both the legal and illegal migrant workers faced unofficial (sirri) marriage problems and their children. This study will analyze the legalization process for the Indonesian migrant worker marriage in Malaysia. The research was done in the region of Peninsular Malaysia, using qualitative research method. The result shows that the legalization process faced some obstacles such as; (1) Malaysian regulation which forbid marriage while under working contract for migrant workers; (2) The difficulty to fulfill the requirements for itsbat nikah (legalizing marriage) because of the distance factor to the Indonesian embassy, hard to get the leaving permit from the employer, and the strict administration for the itsbat nikah program such as the requirements of reference that the applicant has not been married yet in their place of origin.The sirri marriage that is performed by TKI in Malaysia caused many problems such as the one regarding the status of their children’s nationality. They can not be documented by giving them birth certificates, passport, and other documents. Also, their rights are unprotected by the law. This study will have implications on Indonesian government’s policy regarding the protection of TKI’s rights and his family.Keywords: Sirri Marriage, chidren status, Indonesian migrant workers, itsbat nikah Abstrak:Dalam beberapa dekade terakhir, telah terjadi gelombang besar pekerja migran Indonesia atau TKI (Tenaga Kerja Indonesia) di Malaysia, baik secara legal maupun ilegal. Sayangnya, baik pekerja migran legal maupun ilegal menghadapi masalah perkawinan tidak resmi (sirri) dan anak-anak mereka. Studi ini akan menganalisis proses legalisasi perkawinan pekerja migran Indonesia di Malaysia. Penelitian ini dilakukan di wilayah Semenanjung Malaysia, menggunakan metode penelitian kualitatif. Hasil penelitian menunjukkan bahwa proses legalisasi menghadapi beberapa kendala seperti; (1) Peraturan Malaysia yang melarang pernikahan saat berada di bawah kontrak kerja untuk pekerja migran; (2) Kesulitan untuk memenuhi persyaratan untuk itsbat nikah (melegalkan pernikahan) karena faktor jarak ke kedutaan Indonesia, sulit untuk mendapatkan izin cuti dari majikan, dan administrasi yang ketat untuk program itsbat nikah seperti persyaratan referensi bahwa pelamar belum menikah di tempat asal mereka. Pernikahan sirri yang dilakukan oleh TKI di Malaysia menyebabkan banyak masalah seperti yang menyangkut status kewarganegaraan anak-anak mereka. Mereka tidak dapat didokumentasikan dengan memberi mereka akta kelahiran, paspor, dan dokumen lainnya. Juga, hak-hak mereka tidak dilindungi oleh hukum. Studi ini akan memiliki implikasi pada kebijakan pemerintah Indonesia mengenai perlindungan hak TKI dan keluarganya.Kata kunci: Pernikahan Sirri, status anak, pekerja migran Indonesia, itsbat nikah
The Implementation of Supreme Court Regulation Number 2 of 2012 concerning Limitation Adjustment of Mild Criminal Offenses and Amount of Fines in the Criminal Code Towards Handling of Minor Crime Cases
Authors: Fajar Abbas Sofwan Matlail , Rambe Mara Sutan 
Published: July 2019

Abstract:The case of theft with a small value of goods which is now being tried in court is quite under public’s spotlight, public are generally considering that it is very unfair if the cases are threatened with a penalty of 5 (five) years as determined in article 362 of the Criminal Code. Since the punishment is not comparable to the value of the stolen goods, these cases have also encumbered the court, both in terms of the budget and public perceptions of the court. After analyzing the problem, the authors concluded that the application of PERMA Number 2 of 2012 as for Adjustment of Light Crime Limits and the Amount of Mulcts in the Criminal Code has not been used as a Court or Judge as a material consideration or a reference to decide criminal acts whose goods value is below IDR 2,500,000.00 (two million five hundred thousand rupiah).Keywords: Supreme Court Regulations, Mild Crimes, Fines Abstrak:Banyaknya perkara-perkara pencurian dengan nilai barang yang kecil yang kini diadili di pengadilan cukup mendapat sorotan masyarakat, masyarakat umumnya menilai bahwa sangatlah tidak adil jika perkara-perkara tersebut diancam dengan ancaman hukuman 5 (lima) tahun sebagaimana diatur dalam pasal 362 KUHP. Oleh karena tidak sebanding dengan nilai barang yang dicurinya, perkara-perkara tersebut juga telah membebani pengadilan, baik dari segi anggaran maupun dari segi persepsi publik terhadap pengadilan. Setelah menganalisa permasalahan penulis berkesimpulan bahwa penerapan PERMA Nomor 2 Tahun 2012 Tentang Penyesuaian Batasan Tindak Pidana Ringan dan Jumlah Denda dalam KUHP belum dijadikan Pengadilan/Hakim sebagai bahan pertimbangan ataupun acuan untuk memutus tindak pidana yang nilai barangnya di bawah Rp. 2.500.000,00 (dua juta lima ratus ribu rupiah).Kata Kunci: Peraturan Mahkamah Agung, Tindak Pidana Ringan, Denda
Al-Qur’an dan Relasi Antar Umat Beragama; Diskursus Tentang Pendidikan Pluralisme Agama di Indonesia
Authors: Kamarusdiana Kamarusdiana 
Published: July 2019

Abstract:The issue of diversity in religion is a social fact that has continued to experience conflict shocks lately. Not without reason, the conflict occurred on the grounds of sentiment towards other religions. This has an impact on the disruption of the stability of relations between religious groups. The discourse of religious pluralism is an alternative in overcoming this problem. Grounding religious pluralism is the right effort by not injuring religious values. Islam actually provides a clear explanation in the Koran about building a tolerant relationship in religion. This article will explain and provide an explanation of Islamic values in the Qur'an as an effort to develop religious pluralism that needs to be represented in a plural social context. It is hoped that with this, the harmony between religious people will be realized. Besides that, as a concrete follow-up, an education process is needed about the importance of tolerance in religion.Keywords: Qur'an, Tolerance, Religious Pluralism, Harmony AbstrakIsu keberagaman dalam beragama menjadi fakta sosial yang terus mengalami guncangan konflik belakangan ini. Bukan tanpa alasan, konflik tersebut terjadidengan alasan sentimen terhadap agama lain. Hal ini berdampak pada terganggunya stabilitas hubungan antar umat beragama. Wacana pluralisme agama menjadi alternatif dalam mengatasi masalah tersebut. Membumikan pluralisme agama merupakan upaya yang tepat dengan tidak menciderai nilai-nilai agama. Islam sejatinya hadir memberikan penjelasan yang gamblang didalam Alquran tentang membangun hubungan yang toleran dalam beragama. Tulisan ini akan memaparkan sekaligus memberikan penjelasan nilai-nilai keislaman yang ada dalam Alquran sebagai upaya mengembangkan pluralisme agama yang perlu direpresentasikan dalam konteks sosial yang plural. Diharapkan dengannya, akan terwujud kerukunan antar umat beragama.Selain itu, sebagai tindak lanjut yang konkrit dibutuhkan proses edukasi tentang pentingnya toleransi dalam beragama. Kata Kunci: Alquran, Toleransi, Pluralisme Agama, Kerukunan
Humanisme Waris Dalam Islam
Authors: Wahyuni Afidah 
Published: July 2019

Abstract:The inheritance system in Islam reaps several differences of opinion, especially when faced with the values of religious humanism such as the value of brotherhood, freedom and equality. Differences of opinion are more visible in the concept of inheritance between men and women, 2: 1. However, in terms of humanism, justice cannot be separated from human life. Whereas Islam itself has its own meaning about justice; that fair does not always have to be the same. Therefore, the concept of 2: 1 between male and female heirs in Islamic law is not a form of injustice. This is due to the factors behind the development. One of them is the difference in the roles of men and women in family life. Where women get a living, while getting inheritance rights. Whereas men get inheritance rights, but still have to support the women who are in their dependents.Keywords: Inheritance Law, Inheritance Humanism, Islamic Law Abstrak:Sistem waris dalam Islam memang menuai beberapa perbedaan pendapat, apalagi bila dihadapkan pada nilai-nilai humanisme religius seperti nilai persaudaraan, kebebasan, dan persamaan. Perbedaan pendapat lebih terlihat pada konsep pembagian waris antara laki-laki dan perempuan, 2:1. Namun demikian, dalam paham humanisme, keadilan tidak bisa dipisahkan dari kehidupan manusia. Sedangkan Islam sendiri memiliki makna tersendiri tentang keadilan; bahwa adil tidak selalu harus sama. Oleh karena itu, konsep 2:1 antara ahli waris laki-laki dan perempuan dalam syariat Islam, bukan suatu bentuk ketidakadilan. Hal ini disebabkan karena adanya faktor yang melatarbelakangi pembangian tersebut. Salah satunya ialah perbedaan peran laki-laki dan perempuan dalam kehidupan keluarga. Dimana perempuan mendapat nafkah, sekaligus mendapat hak warisan. Sedangkan laki-laki mendapat hak warisan, namun masih harus menafkahi kaum perempuan yang berada di dalam tanggungannya.Kata Kunci: hukum waris, humanisme waris, hukum Islam
Perspektif Ibnu Khaldun Tentang Perubahan Sosial
Authors: Fajar Abbas Sofwan Matlail 
Published: July 2019

Abstract.According to Ibn Khaldun, the paradigm of social change starts from people who have been forged with a hard life, poverty and full of struggle. Nomadic society (badawah, badui, wanderer, rural, village) is the initial social organization. They are sufficient to fulfill their primary needs. If these basic needs have been met, then they seek luxury, live well. Then there is urbanization (civilization), urbanization. Ethically the nomadic group is bolder, better than the city population. Urban social conditions form a tendency to act corruptly. From an ethical perspective, the process of urbanization is degradative. The desire to live with prosperity and be free from the hardships of life coupled with ‘Ashabiyyah among them makes them strive to realize their dreams with a hard struggle. The dream that was achieved then gave rise to a new civilization. The emergence of this new civilization is also usually followed by the decline of another civilization. These stages are then repeated again, and so on until this theory is known as the Cycle Theory.Keywords: Social Change, Ibn Khaldun, Society AbstrakMenurut Ibn Khaldun, paradigma perubahan sosial dimulai dari masyarakat yang telah ditempa dengan kehidupan keras, kemiskinan dan penuh perjuangan. Masyarakat nomadik (badawah, badui, pengembara, rural, desa) adalah organisasi sosial awal. Mereka mencukupkan diri memenuhi kebutuhan primer mereka. Jika kebutuhan mendasar ini sudah terpenuhi, barulah mereka mencari kemewahan, hidup enak. Kemudian berlangsunglah urbanisasi (tamadun), peng-kotaan. Secara etis golongan pengembara lebih berani, lebih baik dibandingkan penduduk kota. Kondisi sosial perkotaan membentuk kecenderungan untuk bertindak korup. Dari sisi etis, proses urbanisasi adalah degradatif. Keinginan hidup dengan makmur dan terbebas dari kesusahan hidup ditambah dengan ‘Ashabiyyah di antara mereka membuat mereka berusaha keras untuk mewujudkan cita-cita mereka dengan perjuangan yang keras. Impian yang tercapai kemudian memunculkan sebuah peradaban baru. Kemunculan peradaban baru ini pula biasanya diikuti dengan kemunduran suatu peradaban lain. Tahapan-tahapan tersebut kemudian terulang lagi, dan begitulah seterusnya hingga teori ini dikenal dengan Teori Siklus.Kata Kunci: Perubahan Sosial, Ibn Khaldun, Masyarakat
Studi Etnografi Dalam Kerangka Masyarakat Dan Budaya
Authors: Kamarusdiana Kamarusdiana 
Published: July 2019

AbstractCommunities with all their cultures have quite strong sociological roots. Culture that results from social interaction makes a distinctive value in that society. The forerunner of culture is an important aspect in the social framework. Research on this aspect of culture uses ethnographic studies. In its implementation ethnography emphasizes the existing aspects of culture. This is an important feature of ethnographic studies. As ethnographic qualitative research conducts in-depth analysis of the culture under study. On the other hand, there is a fairly close link between ethnography and society and culture as a result of their creativity. Therefore, this linkage needs to be applied positively, where it is necessary to use ethnographic studies as an alternative form of conducting research on culture in the community.Keywords: Ethnography, Culture, Society AbstrakMasyarakat dengan segala kebudayaannya memiliki akar sosiologis yang cukup mengakar kuat. Kebudayaan yang dihasilkan dari interaksi sosial menjadikan nilai distingsi tersendiri dalam masyarakat tersebut. Cikal bakal kebudayaan merupakan aspek penting dalam kerangka sosial kemasyarakatan. Penelitian akan aspek kebudayaan ini menggunakan studi etnografi. Dalam implementasinya etnografi menekankan pada aspek kebudayaan yang ada. Hal inilah menjadi ciri penting dari studi etnografi. Sebagai penelitian kualitatif etnografi melakukan analisa secara mendalam terhadap kebudayaan yang diteliti. Disisi lain, terdapat keterkaitan yang cukup erat antara etnografi dengan masyarakat dan kebudayaan sebagai hasil kreatifitasnya. Oleh sebab itu, keterkaitan tersebut perlu diaplikasikan secara positif, di mana perlunya menggunakan studi etnografi sebagai bentuk alternatif dalam melaksanakan penelitian tentang kebudayaan di masyarakat. Kata Kunci: Etnografi, Kebudayaan, Masyarakat