bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the possibilities of classical nova identifications among historical Far Eastern guest star observations
Authors: Vogt Nikolaus , Hoffmann Susanne M. , Tappert Claus 
Published: August 2019

AbstractMore than 100 guest star observations have been obtained by Chinese, Korean, Japanese, and Vietnamese astronomers between ∼600 BCE and ∼1690 CE. Comparing the coordinates from the information given in old texts for eight supernova recoveries with modern supernova remnant positions, we estimate the typical positional accuracy of the order of 0.3–7° for these supernovae. These values could also be a start for the expected deviation angle between a classical nova observed as a guest star and its modern counterpart among known cataclysmic variables (CVs). However, there are considerable disagreements among modern authors regarding the interpretation of ancient Far Eastern texts, emphasizing the need to consult the original historic sources again in order to improve the positioning reliability. We also discuss the typical amplitudes of well‐observed classical novae and find that modern counterparts of nova guest stars should be V = 18 mag and thus easily observable. In this context, we also consider the “hibernation scenario” and conclude that it is impossible to decide from currently available observations whether hibernation is common. In addition to the limiting magnitude of around 2 mag for ancient guest star detections mentioned in the literature, we consider the possibility that fainter guest stars (4–5 mag) could also have been detected by ancient observers and provide arguments in favor of this possibility. For these limits, we compare the expected nova detection rate of ancient naked‐eye observers with that during modern times and conclude that they coincide in order of magnitude, which implies that, indeed, a considerable number of classical nova remnants should be hidden among the Far Eastern guest star reports. Finally, we present a statistical analysis of the probability of casual misidentifications based on frequency and Galactic distribution of CVs in the AAVSO‐Variable Star indeX catalog.
Direct Metal‐Free Chemical Vapor Deposition of Graphene Films on Insulating Substrates for Micro‐Supercapacitors with High Volumetric Capacitance
Authors: Wuttke Michael , Liu Zhaoyang , Lu Hao , Narita Akimitsu , Müllen Klaus 
Published: August 2019

AbstractDirect, metal‐free synthesis of graphene films on insulating substrates in a controlled manner is of great importance for applications in (opto)electronic and energy storage devices. Graphene films are fabricated on fused silica substrates without metal catalyst via chemical vapor deposition (CVD), using propionic acid as a carbon source. Film‐thickness is readily adjustable between 5 and 45 nm by changing the deposition time and flow rate of the precursor, displaying sheet resistance in the range of 0.27–1.86 kΩ□−1. The resulting graphene films are directly integrated into micro‐supercapacitors without film transfer or liquid‐phase processing, and demonstrate ultrahigh operation rates up to 1000 V s−1. Moreover, these films exhibit excellent rate capabilities, achieving a high volumetric capacitance of 131 F cm−3 at 10 mV s−1.
Targeted analysis reveals alteration in pathway in 5p minus individuals
Authors: Furtado Danielle Zildeana Sousa , Leite Fernando Brunale Vilela de Moura , Jedlicka Leticia Dias Lima , Souza Danilo Santos , Barreto Cleber Nunes , da Silva Heron Dominguez Torres , Assunção Nilson Antonio 
Published: August 2019

AbstractCri du Chat or 5p minus (5p−) syndrome is characterized by a deletion located on the chromosome 5 short (−p) arm and has an incidence rate of 1 in 50,000 individuals worldwide. This disease manifests in disturbances across a range of systems biochemicals. Therefore, a targeted metabolomics analysis was evaluated in patients with 5p− syndrome to help unravel the biochemical changes that occur in this disease. Urine samples were collected from people of both sexes aged 1–38 years old and analyzed by ultra‐performance liquid chromatography coupled to mass spectrometry. Student' statistical test, metabolomic pathway analysis and metabolite set enrichment analysis were applied to the data. Alterations of some amino acids and amine biogenics levels were found in Cri du Chat Syndrome individuals. The alteration of most of these metabolites is associated with energy recuperation and glycolysis. In general, we found the catabolism of some metabolic pathways to be affected in 5p− patients.
UPLC–MS/MS study of the effect of dandelion root extract on the plasma levels of the selected irreversible tyrosine kinase inhibitors dasatinib, imatinib and nilotinib in rats: Potential risk of pharmacokinetic interactions
Authors: Alzoman Nourah Z. , Maher Hadir M. , Shehata Shereen M. , Abanmy Norah O. 
Published: August 2019

AbstractTyrosine kinase inhibitor treatments for chronic myeloid leukaemia based on nilotinib (NIL), dasatinib (DAS) and imatinib (IMA) have improved patient quality of life and have turned chronic myeloid leukemia from a fatal disease into a chronic disease. Dandelion is a rich source of phenolic compounds with strong biological properties, and the effects of using this plant in the treatment of different illnesses can be linked to the presence of various polyphenols found in the different parts of the plant. Thus, dandelion can potentially be used as a nutraceutical (dietary antioxidant) to prevent different disorders associated with oxidative stress, i.e. cardiovascular disorders, cancer and inflammatory processes. Mutual interference between a drug and a food constituent may result in altered pharmacokinetics of the drug and undesired or even dangerous clinical situations. In the present study, a bioanalytical ultra performance liquid chromatography–tandem mass spectrometer (UPLC–MS/MS) method was developed and validated for the quantification of DAS, IMA and NIL in rat plasma. Sample preparation was carried out using solid‐phase extraction with C18 cartridges with a good extraction recovery of ≥94.37% for the three drugs. The method was fully validated as per the US Food and Drug Administration guidelines.
Blood pressure and body fat percent in women with NMOSD
Authors: Chen Xiaohong , Fan Rong , Peng Fuhua , Liu Jia , Huang Jing , Chen Zhigang , Chen Yong , Jiang Ying 
Published: August 2019

AbstractBackgroundHypertension is a prevalent and impactful comorbid condition among patients with multiple sclerosis (MS). High level of body mass index (BMI) is associated with the risk and poor outcomes of neuromyelitis optica spectrum disorder (NMOSD) in women. However, the clinical implication of blood pressure (BP) and body fat percent (BF%) based on the Clínica Universidad de Navarra‐Body Adiposity Estimator (CUN‐BAE) in NMOSD has not been investigated thus far.MethodsCase data were collected from 47 NMOSD and 28 MS patients at acute phase, 21 NMOSD and 25 MS patients at stable phase, and 68 age‐ and sex‐matched HCs. Four BP measures including systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), and mean arterial pressure (MAP); BMI; and BF% between NMOSD, MS, and healthy controls were determined.ResultsComparing NMOSD patients with MS patients, the former have significantly higher SBP (p < 0.001), DBP (p < 0.001), PP (p < 0.001), MAP (p < 0.001), BF% (p = 0.001), and BMI (p < 0.001) levels at acute phase after adjusting for age. Acute myelitis (OR 3.719, 95% CI 1.110–12.453) is more likely to occur in NMOSD patients with high BF% (≥30%) at acute phase. BF% was negatively correlated with 1/AQP4 titer in NMOSD at acute phase (r = −0.522, p = 0.004).ConclusionsWomen with NMOSD are probably more prone to have an increased BP and fat mass compared to MS.
Mothers' and fathers' joint profiles for testosterone and oxytocin in a small‐scale fishing‐farming community: Variation based on marital conflict and paternal contributions
Authors: Gettler Lee T. , Sarma Mallika S. , Lew‐Levy Sheina , Bond Angela , Trumble Benjamin C. , Boyette Adam H. 
Published: August 2019

AbstractIntroductionTestosterone and oxytocin are psychobiological mechanisms that interrelate with relationship quality between parents and the quantity and quality of parenting behaviors, thereby affecting child outcomes. Their joint production based on family dynamics has rarely been tested, particularly cross‐culturally.MethodsWe explored family function and salivary testosterone and oxytocin in mothers and fathers in a small‐scale, fishing‐farming society in Republic of the Congo. Fathers ranked one another in three domains of family life pertaining to the local cultural model of fatherhood.ResultsFathers who were viewed as better providers had relatively lower oxytocin and higher testosterone than men seen as poorer providers, who had lower testosterone and higher oxytocin. Fathers also had higher testosterone and lower oxytocin in marriages with more conflict, while those who had less marital conflict had reduced testosterone and higher oxytocin. In contrast, mothers in conflicted marriages showed the opposite profiles of relatively lower testosterone and higher oxytocin. Mothers had higher oxytocin and lower testosterone if fathers were uninvolved as direct caregivers, while mothers showed an opposing pattern for the two hormones if fathers were seen as involved with direct care.ConclusionsThese results shed new light on parents' dual oxytocin and testosterone profiles in a small‐scale society setting and highlight the flexibility of human parental psychobiology when fathers' roles and functions within families differ across cultures.
The incidence of infusion reactions associated with monoclonal antibody drugs targeting the epidermal growth factor receptor in metastatic colorectal cancer patients: A systematic literature review and meta‐analysis of patient and study characteristics
Authors: Bylsma Lauren C. , Dean Rebecca , Lowe Kimberly , Sangaré Laura , Alexander Dominik D. , Fryzek Jon P. 
Published: August 2019

AbstractBackgroundSystemic cancer therapies may induce infusion reactions (IRs) or hypersensitivities. Metastatic colorectal cancer (mCRC) patients treated with anti‐EGFR therapies, including cetuximab and panitumumab, may be subject to these reactions. We conducted a meta‐analysis to estimate the IR incidence in this population and identify variations in this incidence by patient or study characteristics.MethodsA systematic review was conducted to identify observational studies or clinical trials of mCRC patients treated with anti‐EGFR therapies that reported occurrences of IRs, hypersensitivity, or allergy/anaphylaxis. The objective of the study was to estimate the incidence of IRs. Random effects models were used to meta‐analyze the incidence of IRs overall and stratified by therapy type, study design, geographic location, RAS or KRAS mutation status, grade of reaction severity, and terminology used to describe the reaction.ResultsThe pooled estimate for IR incidence was 4.9% (95% confidence interval: 3.6%‐6.5%). Lower‐grade reactions were more common than higher‐grade reactions overall and the incidence of reactions among cetuximab patients was nearly four times that of panitumumab patients (6.1% vs 1.6%).ConclusionsIRs occur in approximately 5% of mCRC patients treated with anti‐EGFR therapies, and the incidence varies significantly by grade of severity and therapy type. Studies evaluating these outcomes should consider investigating survival outcomes by IR status to determine its prognostic relevance.
The diagnostic value of serum gastrokine 1 (GKN1) protein in gastric cancer
Authors: Yoon Jung Hwan , Park Yong Gyu , Nam Suk Woo , Park Won Sang 
Published: August 2019

AbstractEarly detection of cancer provides effective treatment and saves lives. The objective of this study was to determine whether serum gastrokine 1 (GKN1) protein is a gastric cancer‐specific diagnostic biomarker. The serum concentration of GKN1 in healthy individuals (median: 6.34 ng/μL, interquartile range (IQR): 5.66‐7.54 ng/μL) was significantly higher compared with the levels in gastric cancer patients (median: 3.48 ng/μL, IQR: 2.90‐4.11 ng/μL; P < .0001). At the optimum cutoff (4.94 ng/μL) of serum GKN1 protein, the sensitivity and specificity were 91.2% and 96.0%, respectively, for gastric cancer. Using serum GKN1 protein as the diagnostic reference, the ROC curve showed a satisfactory diagnostic efficacy with an AUC value of 0.9954 (95% CI 0.9919‐0.9988) and Youden index of 0.8740. In addition, the diagnostic accuracy of the serum GKN1 protein at the optimum cutoff was 0.9675. Interestingly, serum GKN1 concentrations in patients with advanced gastric cancer (AGC; median: 3.11 ng/μL, IQR: 2.72‐3.72 ng/μL) were lower than in patients with early gastric cancer (EGC; median: 4.31 ng/μL, IQR: 3.88‐4.88 ng/μL). The diagnostic accuracies at the optimum serum GKN1 cutoff were 0.8912 and 0.9589 for EGC and AGC, respectively. Furthermore, the serum GKN1 concentrations robustly discriminated the patients with gastric cancer from the patients with colorectal, liver, lung, breast, pancreatic, ovary, and prostatic cancers with AUC values greater than 0.94. These data suggest that serum GKN1 is a promising and highly specific diagnostic biomarker for the prompt detection of early and advanced gastric cancers.
Burkitt‐like lymphoma with 11q aberration
Authors: Collins Katrina , Mnayer Laila , Shen Peter 
Published: August 2019

AbstractBurkitt‐like lymphoma with 11q aberration is a recently recognized diagnostic entity in the Revised 4th Edition of the World Health Organization (WHO) classification of lymphoid neoplasms. This diagnosis should be considered and cytogenetic array performed in patients with high‐grade B‐cell non‐Hodgkin lymphomas without MYC rearrangement.
Laparoscopic subtotal colectomy for synchronous colon high‐grade dysplasia adenomas in intestinal malrotation: A case report and literature review
Authors: Gerosa Martino , Costanzi Andrea Tullio Mario , Brenna Francesco , Felisaz Paolo Florent , Mari Giulio Maria , Cioffi Ugo , Maggioni Dario 
Published: August 2019

AbstractIntestinal malrotation is an embryologic anomaly rarely presenting in adults especially in association with colon cancer. Fully laparoscopic colonic resection has not yet described in literature for adenomas in malrotation. Preoperative assessment of vascular anatomy by computed tomography is considered mandatory to perform safely laparoscopic surgery.
100 % Digital in der Prozessindustrie
Authors: Wilk Michael , Kockmann Norbert , Woppowa Ljuba 
Published: August 2019

AbstractDigitalisierung und Industrie 4.0 verändern komplette Geschäftsmodelle, heben neue Effizienzpotenziale und stärken die Wettbewerbsfähigkeit. Auf dem 57. Tutzing‐Symposion vom 15.–18.04.2018 wurde mit Vorträgen und Kreativworkshops erkundet, welche speziellen Anforderungen die Prozessindustrie hat, welche digitalen Innovationen bereits umgesetzt wurden und wo noch Handlungsbedarf besteht. Ein Workshop befasste sich mit der Bedeutung der Digitalisierung für Bildung und Lehre.
Gut vorbereitet auf die Krise
Authors: Rübberdt Katrin 
Published: August 2019

AbstractMontagmorgen halb zehn in Deutschland… während Sie gerade in einer Besprechung sitzen und die Optimierungspotenziale einer Produktionsanlage diskutieren, verliert im Hof ein Tankwagen‐Fahrer bei der Anlieferung die Kontrolle über sein Fahrzeug. Er rammt einen Gapelstapler, der gerade Lösungsmittelfässer transportiert. Die Fässer werden beschädigt, Lösungsmittel läuft aus. Aus dem beschädigten Tankwagen treten ebenfalls Chemikalien aus – ein lauter Knall treibt Sie und Ihre Kollegen aus dem Besprechungsraum.
Ein optimales Umfeld für Innovationen
Authors: Deutschland Sauter 
Published: August 2019

AbstractUm ein optimales Umfeld für seine Mitarbeiterinnen und Mitarbeiter zu schaffen, hat Merck das Freiburger Unternehmen Sauter damit beauftragt, seine neues Innovationszentrum in Darmstadt mit moderner Gebäudeautomation auszustatten.
Neues Stoffdatenhandling
Authors: Juschka Katja 
Published: August 2019

AbstractMit der neuen Version 3.10 der hauseigenen Software DSHplus führt Fluidon ein neues Stoffdatenhandling ein. Gegenüber der bisherigen Lösung erlaubt der neue Ansatz dem Anwender, eigene Stoffdatenbeschreibungen zu hinterlegen. Außerdem wurden der Bunsenkoeffizient (Maß für das Gaslösevermögen einer Flüssigkeit) und die Dampfdruckkurve als neue Stoffeigenschaften hinzugefügt. Mit Kenntnis des Dampfdrucks und des Bunsenkoeffizienten können das druckabhängige Wachstum und der Transport von Dampf‐ und/oder Gasblasen in flüssigkeitsgefüllten Leitungssystemen abgebildet werden.
Towards Mechanistic Understanding of Liquid‐Phase Cinnamyl Alcohol Oxidation with tert‐Butyl Hydroperoxide over Noble‐Metal‐Free LaCo1–xFexO3 Perovskites
Authors: Waffel Daniel , Alkan Baris , Fu Qi , Chen Yen‐Ting , Schmidt Stefan , Schulz Christof , Wiggers Hartmut , Muhler Martin , Peng Baoxiang 
Published: August 2019

AbstractNoble‐metal‐free perovskite oxides are promising and well‐known catalysts for high‐temperature gas‐phase oxidation reactions, but their application in selective oxidation reactions in the liquid phase has rarely been studied. We report the liquid‐phase oxidation of cinnamyl alcohol over spray‐flame synthesized LaCo1–xFexO3 perovskite nanoparticles with tert‐butyl hydroperoxide (TBHP) as the oxidizing agent under mild reaction conditions. The catalysts were characterized by XRD, BET, EDS and elemental analysis. LaCo0.8Fe0.2O3 showed the best catalytic properties indicating a synergistic effect between cobalt and iron. The catalysts were found to be stable against metal leaching as proven by hot filtration, and the observed slight deactivation is presumably due to segregation as determined by EDS. Kinetic studies revealed an apparent activation energy of 63.6 kJ mol−1. Combining kinetic findings with TBHP decomposition as well as control experiments revealed a complex reaction network.
Genomic Ancestry,CYP2D6,CYP2C9, andCYP2C19Among Latin Americans
Authors: Rodrigues‐Soares Fernanda , Peñas‐Lledó Eva M. , Tarazona‐Santos Eduardo , Sosa‐Macías Martha , Terán Enrique , López‐López Marisol , Rodeiro Idania , Moya Graciela E. , Calzadilla Luis R. , Ramírez‐Roa Ronald , Grazina Manuela , Estévez‐Carrizo Francisco E. , Barrantes Ramiro , LLerena Adrián ,   RIBEF Ibero‐American Network of Pharmacogenetics and Pharmacogenomics
Published: August 2019

We present the distribution ofCYP2D6,CYP2C9, andCYP2C19variants and predicted phenotypes in 33 native and admixed populations from Ibero‐America (n > 6,000) in the context of genetic ancestry (n = 3,387). Continental ancestries are the major determinants of frequencies of the increased‐activity alleleCYP2C19*17andCYP2C19gUMs (negatively associated with Native American ancestry), decreased‐activity allelesCYP2D6*41andCYP2C9*2(positively associated with European ancestry), and decreased‐activity allelesCYP2D6*17andCYP2D6*29(positively associated with African ancestry). For the rare alleles,CYP2C9*2andCYPC19*17, European admixture accounts for their presence in Native American populations, but rare allelesCYP2D6*5(null‐activity),CYP2D6‐multiplication alleles (increased activity), andCYP2C9*3(decreased‐activity) were present in the pre‐Columbian Americas. The study of a broad spectrum of Native American populations from different ethno‐linguistic groups show how autochthonous diversity shaped the distribution of pharmaco‐alleles and give insights on the prevalence of clinically relevant phenotypes associated with drugs, such as paroxetine, tamoxifen, warfarin, and clopidogrel.
Real‐World Rivaroxaban and Apixaban Levels in Asian Patients With Atrial Fibrillation
Authors: Lin Shin‐Yi , Kuo Ching‐Hua , Yeh Shin‐Joe , Tsai Li‐Kai , Liu Yen‐Bin , Huang Chih‐Fen , Tang Sung‐Chun , Jeng Jiann‐Shing 
Published: August 2019

This study aims to measure the plasma levels of rivaroxaban and apixaban among Asian patients with atrial fibrillation and compare the results with expected drug levels from clinical studies. A total of 73 patients taking rivaroxaban and 105 patients taking apixaban were enrolled. Peak and trough levels were measured using ultra‐high performance liquid chromatography with tandem mass spectrometry. The percentage of those with drug levels within the expected range reported in clinical studies was significantly higher in the apixaban group than in the rivaroxaban group, both for trough (84.8% vs. 64.4%; P = 0.002) and peak levels (76.9% vs. 33.8%; P < 0.001). After adjusting for age, sex, kidney function, appropriate dose, and adherence, patients taking rivaroxaban were still less likely to have peak and trough levels within the expected drug levels. Our real‐world data suggests that Asian patients taking rivaroxaban are more likely to have out‐of‐expected drug levels than those taking apixaban.
Impact of environmental policy on firm's market performance: The case of ISO 14001
Authors: Riaz Hammad , Saeed Abubakr 
Published: August 2019

AbstractEnvironmental Management System, that is, ISO 14001, helps to build corporate reputation, legitimacy, and can also be considered as firms' strategic response to institutional pressure to reduce the impact of business activity on natural environment. It arises the question: does ISO 14001 pay off financially? Unfortunately, this question remains broadly unanswered. Current studies on this issue show mixed and inconclusive findings. By employing rigorous event study approach, this paper compares ISO 14001 certified firms with their noncertified counterpart based on different matching criteria that include size, return on asset, and industry. The results indicate that the ISO 14001 is negatively evaluated by the investors in both the short and long run. This paper also suggests implications for policy makers, managers, and other nonprofit organizations.
A mathematical method to realize complex poles in a high‐order passive switched‐capacitor filter
Authors: Niaboli Guilani Mohammad , Ardeshir Gholamreza 
Published: August 2019

SummaryA high‐order discrete‐time IIR low‐pass with complex poles using charge sampling is presented in a single‐stage structure by using a mathematical strategy. In comparison with the analog complex‐poles Gm‐C filters, the proposed filter consumes lower power and has good linearity, and all of the tunings are implemented only by capacitor sizes. The proposed filter is a seventh‐order Butterworth, but this method can be generalized to implement other complex pole filters like Tchebyshev and Elliptic. Post‐layout simulation results in 130‐nm complementary metal‐oxide‐semiconductor (CMOS) show an IIP3 of +18 dBm and a noise figure of 5 dB. The filter has a rejection of more than 110 dB in its stop band and consumes 1.5 mW with a 1.6‐V supply voltage, and circuit occupies an about 0.12 mm2 of silicon.
Circuit‐based logical layer 2 bridging in software‐defined data center networking
Authors: Wang Yao‐Chun , Lin Ying‐Dar 
Published: August 2019

SummaryWith the expansion of the size of data centers, software‐defined networking (SDN) is becoming a trend for simplifying the data center network management with central and flexible flow control. To achieve L2 abstractions in a multitenant cloud, Open vSwitch (OVS) is commonly used to build overlay tunnels (eg, Virtual eXtensible Local Area Network [VXLAN]) on top of existing underlying networks. However, the poor VXLAN performance of OVS is of huge concern. Instead of solving the performance issues of OVS, in this paper, we proposed a circuit‐based logical layer 2 bridging mechanism (CBL2), which builds label‐switched circuits and performs data‐plane multicasting in a software‐defined leaf‐spine fabric to achieve scalable L2 without overlay tunneling. Our evaluations indicate that direct transmission in OVS improves throughput performance by 58% compared with VXLAN tunneling, and data‐plane multicasting for ARP reduces address resolution latency from 149 to 0.5 ms, compared with control‐plane broadcast forwarding. The evaluation results also show that CBL2 provides 0.6, 0.4, and 11‐ms protection switching time, respectively, in the presence of switch failure, link failure, and port shutdown in practical deployment.