bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a Saffron and Withania Supplement on Mood in Women With Mild‐to‐Moderate Anxiety During the COVID‐19 Lockdown
Authors: Pages-García Cristina , De Almagro M. Cristina , Ruiz-Moreno Jorge , De Castellar Roser 
Published: November 2024

Background: A nutritional supplement based on medicinal plants (saffron and ashwagandha), tryptophan, and vitamin B6 could contribute to alleviating/improving mood and associated disorders. The aim of this study was to evaluate the potential benefits of this combination supplement. During the study period, participants underwent a period of forced home confinement due to the COVID‐19 pandemic, which represented an unexpected impact factor.Methods: This open‐label prospective trial enrolled a cohort of female employees who reported mild to moderate anxiety. The primary objective was to evaluate changes in the level of anxiety using the adapted Hamilton Anxiety Rating Scale (HARS) after 12 weeks of regular supplementation with Safromotive (two tablets daily, for 12 weeks). The secondary objectives were to evaluate health‐related quality of life (HRQoL) and tolerability.Results: In total, 46 women with a mean age of 45.0 (6.5) years were included. A statistically significant improvement in HARS was observed, with a 7.5‐unit decrease from baseline to 12 weeks (p  < 0.0001) and from 4 to 12 weeks of supplement intake (p = 0.0058). However, no significant changes were found during the lockdown period (between weeks 8 and 12 of the study). No relationship was found between women’s sociodemographic characteristics and the HARS total score. A significant reduction in the HRQoL questionnaire score of 1.2 units was observed between baselines and 12 weeks of treatment (p = 0.0273). At the end of the study, 78.6% of the women reported consistency the supplement intake during the study course.Conclusion: This nutritional supplement composed of saffron, ashwagandha, tryptophan, and vitamin B6 appears to improve anxiety and HRQoL, but confinement could have impacted the evolution of the outcome.
Does Fever Caused by the COVID‐19 Virus Before Labor Increase the Rate of MSAF and Affect Maternal and Fetal Outcomes?
Authors: Feng Runrun , Tao Yu , Sun Haiyan , Cao Cen , Gu Hairong , Hu Junmei , Chang Wenwen , Li Xia , Jiang Ziyan 
Published: November 2024

Objective: The main objective of this study is to investigate whether there is a difference in the occurrence of MSAF between fever and nonfever–pregnant women during the COVID‐19 pandemic.Study Design: We conducted a multicenter retrospective study including pregnant women during the COVID‐19 pandemic. Among the 400 pregnant women included in the final data analysis, 238 had fever during delivery, while 162 nonfever–pregnant women met the inclusion and exclusion criteria and served as controls. We collected various obstetric and neonatal parameters for both groups of patients, compared, and statistically tested the significance of these parameters. For parameters with significant statistical differences and clinical significance, we performed logistic regression analysis to explore potential risk factors for MSAF.Result: In a sample of 400 parturients, a total of 69 individuals (17.25%) were discovered to have MSAF with the prevalence increasing to 21.85% in the fever population. A statistically significant association was observed between fever during pregnancy and MSAF, with a higher risk of development observed in fever–pregnant women compared to nonfever ones. Specifically, the odds of developing MSAF increased by a factor of 0.979 in fever‐pregnant women compared to nonfever ones, as determined by a logistic regression model (OR = 1.979, 95% CI = 1.061∼3.693, p = 0.032). Moreover, pregnant women with COVID‐19 infection had a significantly higher risk of developing MSAF, with the odds increasing by a factor of 2.567 compared to uninfected pregnant women (OR = 3.567, 95% CI = 1.622∼7.845, p = 0.002). In addition, the study also identified abnormal fetal heart monitoring (p < 0.05) and gestational age (p < 0.05) as independent risk factors for the occurrence of MSAF.Conclusion: For pregnant women infected with COVID‐19, the rate of MSAF disturbance significantly increases, therefore, it is necessary to pay more attention to fetal heart changes and amniotic fluid conditions, and actively managing labor is beneficial for improving delivery outcomes.
Risk Factors for Refractory Anaphylaxis in the Emergency Department
Authors: Yazıcı Ramiz , Mutlu Hüseyin , Sert Ekrem Taha , Kokulu Kamil , Turan Ömer Faruk 
Published: November 2024

Background: Anaphylaxis is a serious allergic reaction that has a rapid onset and can result in death. Identifying the factors that trigger anaphylaxis and increase its severity is important for preventing refractory anaphylaxis (RA). In this study, we aimed to determine the factors associated with an increased risk of developing RA. Preventive measures to reduce the frequency and intensity of anaphylactic events are essential to provide the best care for allergic patients. Aggravating factors can trigger or increase the severity of anaphylaxis and therefore need to be recognized and avoided.Methods: We retrospectively analyzed the data of 1378 patients over the age of 18 who were diagnosed with anaphylaxis in our clinic between January 1, 2020, and December 31, 2024. We divided the patients into two groups: anaphylaxis and RA. We evaluated the patients’ clinical characteristics in the ED, demographic information, and elicitors that caused anaphylaxis.Results: Of the 1384 anaphylaxis patients included in the study, 46 (3.3%) were diagnosed as RA. We determined that having a history of anaphylaxis is the most important determinant of the increased risk of RA. Having a history of anaphylaxis (OR: 2.87, 95% CI: 1.71–5.72), beta‐blockers/ACEI use (OR: 2.47, 95% CI: 1.71–5.42), IV contrast agent (OR: 2.33, 95% CI: 1.64–5.39), and low blood pressure or related symptoms (OR: 2.34, 95% CI: 1.67–5.43) were more frequently associated with severe reactions.Conclusion: We found that having low blood pressure or related symptoms, a known history of anaphylaxis, beta‐blockers/ACEI, and IV contrast agent are risk factors for RA. To prevent mortality and morbidity in patients with this risk factor, early interventions such as rapidly repeating epinephrine doses and rapid fluid resuscitation should not be avoided.
Alcohol and Cannabis Use Associated with Cardiometabolic Biomarkers among “All of Us” Cancer Survivors
Authors: Arizpe Angel , Chapman Tiffany M. , Rodriguez Claudia , Carvajal Alberto , Queen Katelyn J. , Navarro Stephanie , Ochoa-Dominguez Carol Y. , Kim Sue E. , Toledo-Corral Claudia M. , Farias Albert J. 
Published: November 2024

Abstract

Background:
Cancer survivors are at increased risk for cardiometabolic comorbidities following cancer treatment, which may be further exacerbated by cannabis and alcohol use. We aimed to examine the direct relationships of cannabis, alcohol, and the co-use of both substances with cardiometabolic risk factors and to explore disparities by race/ethnicity and sex.

Methods:
Cross-sectional data were extracted from adult cancer survivors in the “All of Us” from 2018 to 2022. Cannabis use was defined as occasional or frequent/regular cannabis use (vs. never) in the past 3 months and hazardous alcohol intake (AUDIT-C &gt;3 for females; AUDIT-C &gt;4 for males) versus nonhazardous in the past year, respectively. Co-use was defined as participants who engaged in regular cannabis and hazardous alcohol intake. We identified binary cardiovascular, immune, and metabolic system biomarkers, with high values defined by clinically established cutoffs or &gt;75th percentile. We used multivariable logistic regression adjusting for sociodemographic and clinical factors.

Results:
In our sample (N = 7,054), 7.6% were Hispanic, 6.2% were Black, and 86.2% were White cancer survivors. Less than 5% of Hispanic and White survivors reported substance co-use compared with 7% of Black survivors. Compared with never-users, co-users were 1.58 (95% confidence interval, 1.14–2.19) more likely to have high blood pressure. No significant associations were found between co-use and immune biomarkers or sex differences.

Conclusions:
Co-use of cannabis and hazardous alcohol may worsen high blood pressure in survivors, who are at higher risk for cardiometabolic comorbidities.

Impact:
The study investigates substance use and cardiometabolic biomarkers, urging much research on their effects on cancer survivors.
Neuropathological Correlates of White Matter Hyperintensities in Cerebral Amyloid Angiopathy
Authors: Makkinejad Nazanin , Zanon Zotin Maria Clara , van den Brink Hilde , Auger Corinne A. , vom Eigen Kali A. , Iglesias Juan Eugenio , Greenberg Steven M. , Perosa Valentina , van Veluw Susanne J. 
Published: November 2024

Background
White matter hyperintensities (WMHs) are frequently observed on magnetic resonance imaging (MRI) in patients with cerebral amyloid angiopathy (CAA). The neuropathological substrates that underlie WMHs in CAA are unclear, and it remains largely unexplored whether the different WMH distribution patterns associated with CAA (posterior confluent and subcortical multispot) reflect alternative pathophysiological mechanisms.

Methods and Results

We performed a combined in vivo MRI—ex vivo MRI—neuropathological study in patients with definite CAA. Formalin‐fixed hemispheres from 19 patients with CAA, most of whom also had in vivo MRI available, underwent 3T MRI, followed by standard neuropathological examination of the hemispheres and targeted neuropathological assessment of WMH patterns. Ex vivo WMH volume was independently associated with CAA severity (
P
=0.046) but not with arteriolosclerosis (
P
=0.743). In targeted neuropathological examination, compared with normal‐appearing white matter, posterior confluent WMHs were associated with activated microglia (
P
=0.043) and clasmatodendrosis (
P
=0.031), a form of astrocytic injury. Trends were found for an association with white matter rarefaction (
P
=0.074) and arteriolosclerosis (
P
=0.094). An exploratory descriptive analysis suggested that the histopathological correlates of WMH multispots were similar to those underlying posterior confluent WMHs.

Conclusions
This study confirmed that vascular amyloid β severity in the cortex is significantly associated with WMH volume in patients with definite CAA. The histopathological substrates of both posterior confluent and WMH multispots were comparable, suggesting overlapping pathophysiological mechanisms, although these exploratory observations require confirmation in larger studies.
Eight‐Year Outcomes of Cardiosphere‐Derived Cells in Single Ventricle Congenital Heart Disease
Authors: Hirai Kenta , Sawada Ryusuke , Hayashi Tomohiro , Araki Toru , Nakagawa Naomi , Kondo Maiko , Yasuda Kenji , Hirata Takuya , Sato Tomoyuki , Nakatsuka Yuki , Yoshida Michihiro , Kasahara Shingo , Baba Kenji , Oh Hidemasa ,   the TICAP/PERSEUS Study Group
Published: November 2024

Background
Cardiosphere‐derived cell (CDC) infusion was associated with better clinical outcomes at 2 years in patients with single ventricle heart disease. The current study investigates time‐to‐event outcomes at 8 years.

Methods and Results

This cohort enrolled patients with single ventricles who underwent stage 2 or stage 3 palliation from January 2011 to January 2015 at 8 centers in Japan. The primary outcomes were time‐dependent CDC treatment effects on death and late complications during 8 years of follow‐up, assessed by restricted mean survival time. Among 93 patients enrolled (mean age, 2.3±1.3 years; 56% men), 40 received CDC infusion. Overall survival for CDC‐treated versus control patients did not differ at 8 years (hazard ratio [HR], 0.60 [95% CI, 0.21–1.77];
P
=0.35). Treatment effect had nonproportional hazards for death favoring CDCs at 4 years (restricted mean survival time difference +0.33 years [95% CI, 0.01–0.66];
P
=0.043). In patients with heart failure with reduced ejection fraction, CDC treatment effect on survival was greater over 8 years (restricted mean survival time difference +1.58 years [95% CI, 0.05–3.12];
P
=0.043). Compared with control participants, CDC‐treated patients showed lower incidences of late failure (HR, 0.45 [95% CI, 0.21–0.93];
P
=0.027) and adverse events (subdistribution HR, 0.50 [95% CI, 0.27–0.94];
P
=0.036) at 8 years.

Conclusions
By 8 years, CDC infusion was associated with lower hazards of late failure and adverse events in single ventricle heart disease. CDC treatment effect on survival was notable by 4 years and showed a durable clinical benefit in patients with heart failure with reduced ejection fraction over 8 years.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifiers: NCT01273857 and NCT01829750.
Speak So I May See You: Doing Public Theology in an Arab-Muslim Context
Authors: Estafanos Eshak 
Published: November 2024

Abstract
Public theology is a contemporary field that transcends mere trendiness; it stands as a vital imperative for the Arab Church. This imperative arises not only from the need for effective communication with its counterparts but also as a means to bridge the cultural chasm between the East and the West. Rooted in historical legacies and lived realities, Arab Christian theology boasts rich wellsprings of wisdom, yet it also confronts distinct challenges. While it shares commonalities with global public theology, the Arab Church’s presence in this pivotal region renders its public theology distinctive and profoundly significant.
The Rise of Catholic Thought on Social Communication in the Pontificate of Paul VI
Authors: Sánchez-Camacho Jesús 
Published: November 2024

Abstract
In a period of mass media emergence and renewal of Catholicism after Vatican II, the church initiated into a profound approach to its Social Doctrine on the media. With a theology of communication as a cornerstone, numerous ecclesial documents published during the Papacy of Paul VI explored the implications of the media for society and the internal life of the church. This study aims to analyse the contents on the media addressed in official documents of the Catholic Church during the Pontificate of Paul VI. The conclusions of the research show to what extent communication is a significant issue for public theology and delve into the meaning of the right to information and public opinion, the place of the media in education, the training of communicators and recipients, the importance of the media for the church, and the involvement of Catholics in the media.
2. 1st-person wayyiqṭol Morphology
Authors: Hornkohl Aaron D. 
Published: November 2024

The study of 1st-person wayyiqṭol morphology in Biblical Hebrew (BH) reveals three distinct patterns—short, long, and augmented forms—each linked to different historical phases and sources. In Late Biblical Hebrew (LBH) and other post-exilic biblical traditions and extrabiblical sources texts there is a marked preference for long and augmented forms. Bn contrast, Classical Biblical Hebrew (CBH), particularly the Torah, shows a conservative retention of shorter wayyiqṭol forms, reflecting an earlier linguistic stage, as confirmed by comparative data from the Meshaʿ Stele. For their part, non-Pentateuchal CBH texts, i.e., in the Prophets Writings, appear to display a transitional phase, where long forms are common, but augmented forms are rare. Though the historical development of the three patterns is variously explained, the chapter argues that internal diversity within CBH is most compellingly explained as an organic linguistic difference between CBH sub-chronolects. The study raises questions about the conventional dichotomy between CBH and LBH, suggesting the need for finer distinctions within the diachronic framework of Biblical Hebrew. It also weighs implications for the Documentary Hypothesis.
State, Market and Development: Private Sector Participation in Public Services
Authors: Sapra Ipsita , Prakash Aseem 
Published: November 2024

K. B. Saxena, Private Sector Participation in Public Services—Health (Aakar Books, 2022), 296 pp., ₹995, ISBN: 978-9350027615 (Hardback). K. B. Saxena, Private Sector Participation in Public Services—Education (Aakar Books, 2022), 348 pp., ₹995, ISBN: 978-9350027622 (Hardback). K. B. Saxena, Private Sector Participation in Public Services—Civic Amenities (Aakar Books, 2023), 492 pp., ₹1,200, ISBN: 978-9350028070 (Hardback).
Single Center Experience With Sodium-Glucose Co-Transporter-2 Inhibitors (SGLT2i) in Kidney Transplant Recipients With Diabetes
Authors: Angjeli Albi , Montada-Atin Tess , Nisenbaum Rosane , Dacouris Niki , Nash Michelle , Prasad G.V. Ramesh , Zaltzman Jeffrey 
Published: November 2024

Background: Sodium-glucose co-tranporter-2 inhibitors have been shown to be safe and effective in patients with type 2 diabetes for improving glycemia. Furthermore large, randomized control trials have shown cardiovascular and renal benefits. However, limited safety and efficacy data is available in kidney transplant patients with diabetes. Objective: To investigate the safety and efficacy of SGLT2i use on stability of renal function in adult kidney transplant recipients (KTR) with type 2 diabetes mellitus (DM2) or New Onset Diabetes After Transplantation (NODAT). Design: We performed a single center, retrospective cohort study pre- and post-SGLT2i exposure. Patients: Adults with DM2 or NODAT who received a living or deceased kidney transplant (Tx) and started on an SGLT2i post-Tx were reviewed. Patients who had type 1 diabetes were excluded. Measurements and Methods: The baseline was the SGLT2i start date. We reviewed available data from 24 months (M) before and after SGLT2i initiation. The primary endpoints were the effects of SGLT2i use on stability of renal function using serum creatinine and eGFR, change in urine albumin excretion(uACR), and glycosylated hemoglobin (A1C). Secondary endpoints compared blood pressure, body mass index and adverse reactions at baseline and quarterly after SGLT2i initiation. Results: 125 KTRs were included in cohort: NODAT (52, 42%), DM2 (73, 58%); female (33, 27%); mean age at Tx 55 years (25-75); LD (56, 45%), DD (69, 55%); mean duration of Tx (6.8 years, 0.1-42.5); study follow-up (1.8 years, 0.3-4.9). The mean eGFR remained stable pre-SGLT2i at 64.6 mL/min/1.73m2, vs post at 64.3 mL/min/1.73m2. There was no difference in mean A1C after SGLT2i initiation. The slope of uACR using natural log transformation pre-SGLT2i compared with post-SGLT2i slope reduced from +0.7 (0.03, 0.11) to -0.04 (-0.01, -0.35) mg/mmol/3mths ( P = .002). The risk of developing new genital mycotic infections among all patients was 4% (95% CI 1.3%-9.1%) While there was no significant difference in UTI before (13.6%) and after (12%) SGLT2i use ( P = .68), there was a higher risk of UTI seen in patients with a previous history of UTI (23.5%) vs no previous history (10.2%) post initiation. There was no significant increase in AKI pre 8%, post 10.4%, P = .51. There was a single DKA event pre- and post-SGLT2. Limitations: The limitations of this study include its retrospective nonrandomized nature. Conclusion: In this retrospective analysis, SGLT2i use in KTR appears to be safe and efficacious with stable renal function and glycemic control, alongside improvements in uACR. There was a low risk of new genital yeast infections after SGLT2i start. UTI occurrence was higher in patients with a previous history of UTI compared with those with no previous history.
CerviXpert: A multi-structural convolutional neural network for predicting cervix type and cervical cell abnormalities
Authors: Akash Rashik Shahriar , Islam Radiful , Badhon SM Saiful Islam , Hossain KSM Tozammel 
Published: November 2024

Objectives Cervical cancer, a leading cause of cancer-related deaths among women globally, has a significantly higher survival rate when diagnosed early. Traditional diagnostic methods like Pap smears and cervical biopsies rely heavily on the skills of cytologists, making the process prone to errors. This study aims to develop CerviXpert, a multi-structural convolutional neural network designed to classify cervix types and detect cervical cell abnormalities efficiently. Methods We introduced CerviXpert, a computationally efficient convolutional neural network model that classifies cervical cancer using images from the publicly available SiPaKMeD dataset. Our approach emphasizes simplicity, using a limited number of convolutional layers followed by max-pooling and dense layers, trained from scratch. We compared CerviXpert’s performance against other state-of-the-art convolutional neural network models, including ResNet50, VGG16, MobileNetV2, and InceptionV3, evaluating them on accuracy, computational efficiency, and robustness using five-fold cross-validation. Results CerviXpert achieved an accuracy of 98.04% in classifying cervical cell abnormalities into three classes (normal, abnormal, and benign) and 98.60% for five-class cervix type classification, outperforming MobileNetV2 and InceptionV3 in both accuracy and computational demands. It demonstrated comparable results to ResNet50 and VGG16, with significantly reduced computational complexity and resource usage. Conclusion CerviXpert offers a promising solution for efficient cervical cancer screening and diagnosis, striking a balance between accuracy and computational feasibility. Its streamlined architecture makes it suitable for deployment in resource-constrained environments, potentially improving early detection and management of cervical cancer.
Early and late phases of liver sinusoidal endothelial cell (LSEC) defenestration in mouse model of systemic inflammation
Authors: Czyzynska-Cichon Izabela , Kotlinowski Jerzy , Blacharczyk Oliwia , Giergiel Magdalena , Szymanowski Konrad , Metwally Sara , Wojnar-Lason Kamila , Dobosz Ewelina , Koziel Joanna , Lekka Malgorzata , Chlopicki Stefan , Zapotoczny Bartlomiej 
Published: November 2024

Abstract
Background
Liver sinusoidal endothelial cells (LSECs) have transcellular pores, called fenestrations, participating in the bidirectional transport between the vascular system and liver parenchyma. Fenestrated LSECs indicate a healthy phenotype of liver while loss of fenestrations (defenestration) in LSECs is associated with liver pathologies.

Methods
We introduce a unique model of systemic inflammation triggered by the deletion of Mcpip1 in myeloid leukocytes (Mcpip1fl/flLysMCre) characterised by progressive alterations in LSEC phenotype. We implement multiparametric characterisation of LSECs by using novel real-time atomic force microscopy supported with scanning electron microscopy and quantitative fluorescence microscopy. In addition, we provide genetic profiling, searching for characteristic genes encoding proteins that might be connected with the structure of fenestrations.

Results
We demonstrate that LSECs in Mcpip1fl/flLysMCre display two phases of defenestration: the early phase, with modest defenestration that was fully reversible using cytochalasin B and the late phase, with severe defenestration that is mostly irreversible. By thorough analysis of LSEC porosity, elastic modulus and actin abundance in Mcpip1fl/flLysMCre and in response to cytochalasin B, we demonstrate that proteins other than actin must be additionally responsible for inducing open fenestrations. We highlight several genes that were severely affected in the late but not in the early phase of LSEC defenestration shedding a light on complex structure of individual fenestrations.

Conclusions
The presented model of LSEC derived from Mcpip1fl/flLysMCre provides a valuable reference for developing novel strategies for LSEC refenestration in the early and late phases of liver pathology.