bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of anhedonia, anxiety, and their impact on food consumption among postgraduate Qassim University students
Authors: Alrehaili Sarah , Afifi Abeer A. , Algheshairy Reham M. , Bushnaq Taqwa , Alharbi Talal Ali F. , Alharbi Hend F. 
Published: October 2024

ObjectivesA prevalent symptom of many mental health issues, such as depression, is anhedonia, which is the inability to feel joy or pleasure. Tension-induced sensations, anxious thoughts, and bodily alterations are the hallmarks of anxiety. One known environmental factor that affects mental health is diet. In this implication, eating appetizing meals has been proposed to reduce unpleasant feelings like worry. This study aimed to indicate whether eating habits among postgraduate students are related to symptoms of anhedonia and/or anxiety.MethodsIn a cross-sectional study, responses were collected from a total of 393 postgraduate students. Each student self-answered the General Anxiety Disorder-7, Snaith-Hamilton Pleasure Scale for Anhedonia, and the Food Consumption Questionnaire and reported the body weight.ResultsThe prevalence of anhedonia was 28%, moderate anxiety and severe anxiety were 15.7 and 10.9%, respectively. In this research, results showed that sugary foods, fast food, and fried foods were positively associated with anxiety and anhedonia. However, fruits and vegetables were negatively associated with anxiety and anhedonia. Linear regression showed that fruit and drinking water consumption was significant with the number of meals/day. There was no significance between the number of meals per day and anhedonia; however, there was statistical significance with the total GAD-7 scale score regarding the number of meals/per day.ConclusionAnhedonia and anxiety are associated with food consumption, especially foods rich in sugars, fast and fried, which help to increase positive feelings. Future studies should focus on understanding the relationship between food consumption and following a healthy diet and improving and reducing symptoms of anxiety and anhedonia in those who suffer from a stressful or task-filled lifestyle, such as students, especially postgraduate students. In addition, it focuses on the importance of awareness of the symptoms of anhedonia, which is classified as a depressive disease, and how to control anxiety to maintain better mental health.
Education and metabolic syndrome: a Mendelian randomization study
Authors: Liu Dong , Xu Zi-Xiang , Liu Xue-lian , Yang Hai-Ling , Wang Ling-ling , Li Yan 
Published: October 2024

AimsThe metabolic syndrome (MetS), a collection of conditions that heighten the risk of disease development and impose economic burdens on patients. However, the causal relationship between education and MetS was uncertain. In this study, the Mendelian randomization (MR) method was employed to elucidate the potential causal link between education and the MetS and its components.MethodSingle nucleotide polymorphisms (SNPs) associated with education, MetS, and its components were sourced from a public database, with the inverse variance-weighted (IVW) method utilized for analysis.ResultsEducation demonstrated a significant negative correlation with the risk of MetS (OR = 0.55, 95% CI = 0.48–0.63, p = 2.18E−51), waist circumference(OR = 0.80, 95% CI = 0.76–0.83, p = 4.98E-33), hypertension (OR = 0.96, 95% CI = 0.95–0.97; p = 4.54E-10), Fasting blood glucose (OR = 0.94, 95% CI = 0.91–0.97, p = 7.58E-6) and triglycerides (OR = 0.83, 95% CI = 0.79–0.87, p = 7.87E-18) while showing a positive association with high-density lipoprotein cholesterol (OR = 1.22, 95% CI = 1.18–1.25, p = 1.45E-31).ConclusionThe findings of this study suggest that education can decrease the incidence of MetS.
Modulating the gut microbiota in Crohn’s disease: a pilot study on the impact of a plant-based diet with DNA-based monitoring
Authors: Østergaard Stine Karstenskov , Cetin Zeynep , Rasmussen Henrik Højgaard , Lærke Helle Nygaard , Holst Mette , Lauridsen Charlotte , Nielsen Jeppe Lund 
Published: October 2024

IntroductionCrohn’s Disease (CD) is characterized by chronic intestinal inflammation and dysbiosis. This study aimed to investigate the effects of a plant-based diet (PBD) on gut microbiota composition and inflammation in CD patients and assess the utility of trnL gene sequencing for monitoring dietary adherence.MethodsFourteen CD patients participated in a 12-week PBD intervention. Dietary adherence was monitored through self-reported food diaries and trnL sequencing, which detects plant residues in fecal samples. Gut microbiota was analyzed using 16S rRNA sequencing, and fecal calprotectin levels were measured as an indicator of intestinal inflammation.ResultsTrnL sequencing identified 55 plant genera in fecal samples, compared to 41 reported in food diaries, highlighting its accuracy in assessing plant residue diversity. By week 4, participants demonstrated a 1.4-fold increase in plant intake, correlating with a significant increase in microbial diversity. Key genera associated with gut health, such as Faecalibacterium and Bacteroides, increased in abundance. Additionally, fecal calprotectin levels decreased from 472 mg/kg at baseline to 207 mg/kg at week 12, indicating reduced intestinal inflammation.DiscussionA PBD positively influenced gut microbiota composition and decreased intestinal inflammation in CD patients. The study also demonstrated that trnL sequencing is an effective tool for assessing dietary adherence in clinical settings, offering a more objective measure than self-reported food diaries.
LCGSC-YOLO: a lightweight apple leaf diseases detection method based on LCNet and GSConv module under YOLO framework
Authors: Wang Jianlong , Qin Congcong , Hou Beibei , Yuan Yuan , Zhang Yake , Feng Wenfeng 
Published: October 2024

IntroductionIn response to the current mainstream deep learning detection methods with a large number of learned parameters and the complexity of apple leaf disease scenarios, the paper proposes a lightweight method and names it LCGSC-YOLO. This method is based on the LCNet(A Lightweight CPU Convolutional Neural Network) and GSConv(Group Shuffle Convolution) module modified YOLO(You Only Look Once) framework.MethodsFirstly, the lightweight LCNet is utilized to reconstruct the backbone network, with the purpose of reducing the number of parameters and computations of the model. Secondly, the GSConv module and the VOVGSCSP (Slim-neck by GSConv) module are introduced in the neck network, which makes it possible to minimize the number of model parameters and computations while guaranteeing the fusion capability among the different feature layers. Finally, coordinate attention is embedded in the tail of the backbone and after each VOVGSCSP module to improve the problem of detection accuracy degradation issue caused by model lightweighting.ResultsThe experimental results show the LCGSC-YOLO can achieve an excellent detection performance with mean average precision of 95.5% and detection speed of 53 frames per second (FPS) on the mixed datasets of Plant Pathology 2021 (FGVC8) and AppleLeaf9.DiscussionThe number of parameters and Floating Point Operations (FLOPs) of the LCGSC-YOLO are much less thanother related comparative experimental algorithms.
Exploring mindfulness interventions across cultures: a comparative meta-analysis of mindfulness interventions for athletes in Western and Eastern contexts
Authors: Du Senyao , Ning Ziheng 
Published: October 2024

ObjectiveApplying mindfulness training across cultures can be challenging because its internal motivation depends on values, but there are differences between Western and Eastern contexts. This meta-analysis examines the comparative impacts of the Western Mindfulness-Acceptance-Commitment (MAC) approach and the culturally-adapted Chinese Mindfulness-Acceptance-Insight-Commitment (MAIC) mindfulness training for athletes, to explore the importance of cultural adaptation in cross-cultural psychology to psychological skills training.MethodsThis meta-analysis was registered with Prospero (ID: CRD42023474474) and adhered to the PRISMA principles. The PICO search methodology was employed to identify pertinent Chinese and English literature across six databases (Web of Science, PubMed, Scopus, CNKI, Wanfang, and VIP) from 2003 to 2023. The evidence originated from randomized controlled trials. Effect sizes were evaluated across three primary domains: athletic performance, mindfulness, and psychological flexibility, and heterogeneity and publication bias.ResultsBoth MAC and MAIC demonstrated positive effects across all outcome categories in 18 studies. MAIC exhibited substantially larger effect sizes compared to MAC. In mindfulness (MAIC: g = 1.273, p &lt; 0.001; MAC: g = 0.521, p = 0.001), sports performance (MAIC: g = 0.945, p = 0.015; MAC: g = 0.550, p &lt; 0.001), MAC did not provide evidence of improved psychological flexibility (g = 0.076, p = 0.747), while MAIC demonstrated significant benefits (g = 0.964, p &lt; 0.001).DiscussionWhile MAIC is based on MAC, it yields more significant outcomes. This may be the “Insight” component introduced by MAIC, which skillfully integrates Eastern context. The MAIC strategy not only becomes more appropriate for local athletes but also indirectly enhances their mindfulness, athletic performance, and psychological flexibility, resulting from cultural adaptation. The new idea not only solves the culture shock caused by the direct application of Western MAC approach on Chinese athletes, but also provides a new solution to the problem that there is insufficient evidence to support the effect of the MAC approach on “psychological flexibility.” Investigating differential effects between MAC and MAIC contributes to understanding the significance of culturally adapting mindfulness training and transnational movement of practices. The findings will assist practitioners in selecting evidence-based protocols tailored to athlete needs and cultural contexts.Systematic review registrationProspero (ID: CRD42023474474).
Longitudinal trajectories of the overall and regional body composition between severe acute malnourished and well-nourished children of Rohingya refugee camps
Authors: Manir Mohammad Zahidul , Huq A. K. Obidul 
Published: October 2024

ObjectivesThe present study aimed to observe how body composition differs between severe acute malnutrition (SAM) (treated with ready-to-use therapeutic food, RUTF) and well-nourished children.MethodsA longitudinal investigation was conducted among well-nourished and SAM children of 6-59 months in Rohingya refugee camps. These two groups (350 children in each group) of children were observed over 12 weeks and individual data were collected during admission, follow-up visits, and at the time of discharge. Anthropometric information was collected following standard procedures. The thicknesses of the biceps, triceps, subscapular, and supra iliac skinfolds were measured using a Herpenden-type skinfold caliper. Separate linear mixed models were conducted to assess associations of the independent variables (i.e., group and time) with each of the dependent variables (i.e., biceps, triceps, subscapular, supra-iliac skinfold thickness (ST), fat mass (FM), and fat-free mass (FFM)).ResultsBoth in well-nourished and SAM children, the mean biceps, triceps, subscapular, and supra-iliac ST, FM, and FFM increased over the 12 weeks. The increase in biceps ST was significantly faster in the SAM children compared to the well-nourished children (difference in slope = 0.366 mm every four weeks; p &lt; 0.001). The increment rate in triceps ST was also faster in the SAM children compared to the well-nourished children (difference in slope = 0.430 mm every four weeks; p &lt; 0.001). Moreover, the pace of increase in subscapular (difference in slope = 0.027 mm every four weeks; p &lt; 0.001), and supra-iliac (difference in slope = 0.211 mm every four weeks, p &lt; 0.001) ST was also significantly higher in the SAM group. Similarly, the change in FM (difference in slope = 0.065 kg every four weeks, p &lt; 0.001) and FFM (difference in slope = 0.152 kg every four weeks, p = 0.023) was also significantly faster in SAM children compared to the well-nourished children over the treatment period. Furthermore, the girls gained significantly higher triceps ST, subscapular ST, FM, and FFM compared to the boys.ConclusionThe benefit of RUTF was evident from this longitudinal study in the recovery of FM and FFM contents among the SAM children of Rohingya refugee camps.
Predicting IDH and ATRX mutations in gliomas from radiomic features with machine learning: a systematic review and meta-analysis
Authors: Chung Chor Yiu Chloe , Pigott Laura Elin 
Published: October 2024

ObjectiveThis systematic review aims to evaluate the quality and accuracy of ML algorithms in predicting ATRX and IDH mutation status in patients with glioma through the analysis of radiomic features extracted from medical imaging. The potential clinical impacts and areas for further improvement in non-invasive glioma diagnosis, classification and prognosis are also identified and discussed.MethodsThe review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Diagnostic and Test Accuracy (PRISMA-DTA) statement. Databases including PubMed, Science Direct, CINAHL, Academic Search Complete, Medline, and Google Scholar were searched from inception to April 2024. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool was used to assess the risk of bias and applicability concerns. Additionally, meta-regression identified covariates contributing to heterogeneity before a subgroup meta-analysis was conducted. Pooled sensitivities, specificities and area under the curve (AUC) values were calculated for the prediction of ATRX and IDH mutations.ResultsEleven studies involving 1,685 patients with grade I–IV glioma were included. Primary contributors to heterogeneity included the MRI modalities utilised (conventional only vs. combined) and the types of ML models employed. The meta-analysis revealed pooled sensitivities of 0.682 for prediction of ATRX loss and 0.831 for IDH mutations, specificities of 0.874 and 0.828, and AUC values of 0.842 and 0.948, respectively. Interestingly, incorporating semantics and clinical data, including patient demographics, improved the diagnostic performance of ML models.ConclusionsThe high AUC in the prediction of both mutations demonstrates an overall robust diagnostic performance of ML, indicating the potential for accurate, non-invasive diagnosis and precise prognosis. Future research should focus on integrating diverse data types, including advanced imaging, semantics and clinical data while also aiming to standardise the collection and integration of multimodal data. This approach will enhance clinical applicability and consistency.
Liver Transplantation for Intrahepatic Cholangiocarcinoma After Chemotherapy and Radioembolization: An Intention-To-Treat Study
Authors: Maspero Marianna , Sposito Carlo , Bongini Marco A. , Cascella Tommaso , Flores Maria , Maccauro Marco , Chiesa Carlo , Niger Monica , Pietrantonio Filippo , Leoncini Giuseppe , Bellia Valentina , Bhoori Sherrie , Mazzaferro Vincenzo 
Published: October 2024

Liver transplantation (LT) is a potentially curative experimental treatment for unresectable intrahepatic cholangiocarcinoma (iCC). Pre-transplant downstaging may help defining tumor aggressiveness and drive patient selection. We report the preliminary results of LT for liver-limited unresectable iCC after sequential downstaging with systemic chemotherapy and radioembolization (SYS-TARE). In case of sustained disease stability after SYS-TARE, patients underwent surgical nodal sampling and, if negative, were listed for LT. In this study, 13 patients with unresectable iCC underwent downstaging with SYS-TARE. The median age was 70 years and 77% were female. All had single bulky lesions at diagnosis. After SYS-TARE, 9 (69%) dropped out: 3 due to progressive disease after TARE with no response to second-line, 4 due to extrahepatic disease development and 2 due to positive nodal disease at pre-listing abdominal exploration. The median OS after dropout was 11.5 months. Four (31%) were successfully listed and transplanted. At pathology, viable tumor ranged from 30% to less than 5%. All four patients are alive and disease-free at 73, 40, 12, and 8 months from LT. LT for unresectable iCC after downstaging with SYS-TARE appears to select suitable patients for LT, achieving optimal oncological outcomes in case of response to therapy and no lymphnodal spread.
ТРАВМАТИЗМ СРЕДИ ПАЦИЕНТОВ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА ПО ДАННЫМ ТРАВМАТОЛОГИЧЕСКОГО ОТДЕЛЕНИЯ ПАВЛОДАРСКОЙ ГОРОДСКОЙ БОЛЬНИЦЫ № 1
Authors: К.Р. Акильжанов , А.О. Мысаев 
Published: October 2024

В статье представлены результаты рестроспективного медико-статистического и социально-гигиенического исследования госпитализаций лиц пожилого и старческого возраста с травмами по данным травматологического отделения Городской больницы №1 города Павлодар за 2012-2014 годы.
The article presents the results of a retrospective statistical and socio-hygienic study of hospital admissions of elderly and senile aged persons with injuries according to the trauma department of Pavlodar city hospital №1 for 2012-2014 year period.
innovative therapies, elderly age, trauma, trauma care, efficiency.
ИННОВАЦИОННЫЙ МЕНЕДЖМЕНТ В ГОСУДАРСТВЕННОМ МЕДИЦИНСКОМ УНИВЕРСИТЕТЕ ГОРОДА СЕМЕЙ: ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ
Authors: Д.С. Серикова-Есенгельдина , Д.К. Кусаинова , Д.С. Жумажанова , Ф.С. Рахимжанова 
Published: October 2024

Введение.Статья посвящена актуальной проблеме: переходу к инновационному менеджменту как новому взгляду на взаимоотношения в системе подготовки высших медицинских кадров нового поколения. Цель исследования. Предложить в качестве механизма эффективного применения инновационного менеджмента внедрение системы обучения менеджеров всех уровней основам управления инновациями. Методы. Проведен ситуационный анализ перехода ГМУ г. Семей к системе инновационного менеджмента, обзор имеющихся достижений, а также обозначены проблемы расширения компетенций менеджеров здравоохранения, предложены возможные пути их решения. Выводы.В качестве перспективы решения стоящих перед ВУЗом задач определена всеобъемлющая подготовка менеджеров всех уровней основам инновационного менеджмента, с целью дальнейшего обучения ими студентов, магистрантов.
12 years teaching undergraduate in the specialty of «Public health»; 2M.D., associate professor, department of Public Health Introduction. The article is devoted to the actual problem: the transition to innovation management as a new way of looking at the relationship in the training of senior medical staff of the new generation. The purpose of the study. To suggest the introduction of manager’s teaching system as the mechanism of efficient application of innovative management. Methods. Analysis of transition of Semey state medical university to innovation management system and review of existing achievements has been carried out. Problems of competence extension of health managers have been specified. Possible solution to the problems has been offered. Conclusions. Comprehensive training of managers of all levels to basis of innovative management and further teaching students and masters is determined as the solution of the problems facing the University.
Кіріспе.Мақала өзекті мәселеге арналған: инновациялық менеджментке көшу барысында жаңа буынды жоғары медициналық қызметкерлерлерді дайындау кезіндегі қарым-қатынас жүйесіне жаңа көзқарасты қолдану. Зерттеу мақсаты. Инновациялық басқарудың барлық деңгейлеріндегі негіздерді менеджерлердің оқыту жүйесін инновациялық менеджментке енгізуді тиімді қолданудың механизмдері ретінде ұсыну. Әдістер. Семей мемлекеттік медициналық университетінің инновациялық менеджмент жүйесіне көшу барысында жағдайды талдау, жетістіктерін қарау, денсаулық сақтау менеджерлерінің біліктілігін кеңейту мәселелері қарастырылып, оның ықтимал шешу жолдары ұсынылған. Қорытынды. Жоғарғы оқу орнының алдында тұрған мәселелерді шешу перспективалардың бірі инновациялық менеджмент негіздерін барлық деңгейлеріндегі менеджерлерді даярлау анықталған, одан әрі мақсатында студенттер мен магистранттарды оқыту.
ГОРМОНАЛЬНАЯ АКТИВНОСТЬ ЖИРОВОЙ ТКАНИ У БОЛЬНЫХ ОСТЕОАРТРОЗОМ И ОЖИРЕНИЕМ
Authors: Л.М. Пасиешвили , К.И. Терешкин 
Published: October 2024

Изучено содержание и роль адипокина жировой ткани – апелина – у 49 больных с деформирующим остеоартрозом (ДОА) и при его сочетании с ожирением (32 из всех обследованных). Установлено достоверное увеличение данного показателя у больных с ожирением и ДОА. Выявлена прямая корреляционная зависимость между уровнем апелина и индексом массы тела (r=0,43), апелином и инсулинорезистентностою (r=0,46) и обратная – cдлительностью анамнеза по ДОА (r=-0,61). У больных с ДОА и нормальной массой тела уровень апелина имел лишь тенденцию к повышению при сравнении с показателями контроля. Учитывая роль апелина в организме – катаболизм хрящевой ткани – данный показатели можно использовать с диагностической целью.
Studed the content and role of adipose tissue adypokin`s – apelin in patients with osteoarthritis (OA) and when it is combined with obesity (32 out of all surveyed). Determined a significant increase in this indicator in patients with obesity and OA. A direct correlation between the level of apelin and body mass index (r=0,43), apelin and insulin resistance (r=0,46) and reverse – with long history on DOA (r=-0,61). Patients with OA and normal weight level was increased insignificantly apelin compared with the control. Defining the role of apelin in the body – carries the catabolism of cartilage – this indicator can be used for diagnostic purposes.
Май тіндері адипокиндерінің - апелиннің мәні мен рөлі зерделенді – деформацияланған остеоартрозбен (ДОА) 49 науқаста және оның семіздікпен бірігуі кезіндегі (барлық тексерлігендердің 32). Семіздікпен және ДОА науқастардағы осы көрсеткіштерлің нақты өсуі анықталды. Апелиннмен және дене салмағы индексі деңгейі арасындағы тура түзету тәуелділігі анықталды (r=0,43), апелинмен және инсулиндікрезистентностілік (r=0,46) және кері – ДОА бойынша анамнездің ұзақтығымен (r=-0,61). ДОА мен науқастарда және қалыпты дене салмағымен апелиннің деңгейі бақылау көрсеткіштерімен салыстырған кезде арту тенденциясы ғана болды.ағзадағы апеллиннің рөлін ескере отырып - шеміршек тінінің катаболизмі- осы көрсеткішті диагностикалық мақсатта пайдалануға болады