bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between TNF-receptors (TNFR1 and TNFR2) and mortality as well as kidney function decline in patients with chronic kidney disease
Authors: Wändell Per , Feldreich Tobias , Larsson Anders , Kalra Philip A. , Ärnlöv Johan , Ruge Toralph , Carlsson Axel C. 
Published: November 2024

Background: Higher circulating levels of tumor necrosis factor (TNF) alpha receptors 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function.
Aim: To study associations between levels of TNFR1 and TNFR2 and all-cause mortality as well as estimated glomerular filtration rate (eGFR) decline.
Population and methods: Patients with chronic kidney disease (CKD) stages 3–5 in the Salford Kidney Study were included. Associations between one standard deviation increase in plasma TNFR1 and TNFR2 and mortality were estimated by Cox regression models with hazard ratios (HRs) and 95% confidence intervals adjusted for age, sex, eGFR based on creatinine and cystatin C, urine-protein, C-reactive protin, cardiovascular comorbidity, smoking habits, and diabetes. Differences in eGFR decline in relation to plasma TNFR1 and TNFR2 were estimated by both linear and logistic regression models, with regression coefficients and odds ratios (ORs).
Results: Univariate models showed significant associations between TNFR1 (n = 985) and TNFR2 (n = 988) and all-cause mortality based on 7424 person-years at risk, but in the fully adjusted models with continuous variables significant only for TNFR2 HR 1.17 (1.03–1.34), but with a borderline value for TNFR1 HR 1.15 (1.00–1.31). For rapid decliners, that is, eGFR decline in highest TNFR-receptor quartile versus quartiles 1–3, the decline was 1.60% per month (interval 0.78–10.99). For eGFR decline in continuous models, the fully adjusted ORs were for TNFR1 1.29 (0.92–1.81) and for TNFR2 1.33 (0.90–1.98).
Conclusions: TNFR2 was associated with mortality, but TNFR1 was not, although showing a borderline value. Neither TNFR1 nor TNFR2 predicted decline in kidney function. TNFR1 and TNFR2 portray interesting aspects in patients with CKD, but the clinical utility seems limited.
Talbotiella couteronii (Leguminosae: Detarioideae), a new gregarious tree species from Cameroon
Authors: Sonké Bonaventure , Simo-Droissart Murielle , Bidault Ehoarn , Ngoula Fernandez , van der Burgt Xander M 
Published: November 2024

Background and aims – For some time now, the forests of the Sanaga basin in Cameroon have been threatened by the construction of numerous hydroelectric dams. In anticipation to this construction work, botanical surveys were carried out, resulting in the discovery of many species new to science. One of these certainly belongs to the genus Talbotiella in Leguminosae.
Material and methods – This study is based on morphological observations on herbarium specimens, through detailed examination of 28 specimens of the new tree species as well as specimens of existing species of Talbotiella.
Key results – Talbotiella couteronii is described and illustrated. The new species resembles Talbotiella batesii but has fewer leaflets, 5–10 pairs; an inflorescence usually with fewer flowers, 5–12; and flowers with longer pedicels, 10–20 mm long. Talbotiella couteronii is endemic to Cameroon, where it is restricted to the middle Sanaga basin in the Central Region and the Littoral Region. It occurs gregariously in periodically flooded riverine forests. Talbotiella couteronii is preliminarily assessed as Endangered following the IUCN Red List categories and criteria. The genus Talbotiella now consists of 10 species; of which six species are endemic to Cameroon. A comparative table summarizes the main vegetative characteristics of the 10 species. This treatment also includes an update of the description of T. bakossiensis.
EIXO INTESTINO-PELE: A INFLUÊNCIA DA MICROBIOTA INTESTINAL NO ENVELHECIMENTO CUTÂNEO
Authors: Martins Thailaine Scotti , Andrade Mariana Moreira 
Published: November 2024

Introdução: A ligação bidirecional entre a homeostase cutânea e a disbiose, bem como a influência da microbiota intestinal e seu potencial imunomodulador em órgãos distantes como a pele, tornou-se um campo de pesquisa em expansão, acompanhando o fenômeno do envelhecimento populacional juntamente com o desenvolvimento de estratégias prevenir o envelhecimento prematuro e retardar o envelhecimento cronológico de forma saudável. Materiais e Métodos: Trata-se de uma revisão narrativa da literatura, utilizando descritores como envelhecimento cutâneo, disbiose intestinal, microbiota intestinal, eixo intestino-pele, probióticos e prebióticos. As bases de dados eletrônicas pesquisadas foram NCBI, PubMed, Scielo e Google Scholar. A pesquisa foi realizada entre março e novembro de 2024, nos idiomas inglês e português. Um total de 25 artigos foram utilizados como base para o estudo em questão. Referencial Teórico: Desequilíbrios na microbiota, conhecidos como disbiose, podem comprometer a função imunológica e a saúde da pele, contribuindo para o envelhecimento cutâneo. Fatores como dieta e medicamentos influenciam a disbiose e sua relação com o envelhecimento. Estudos recentes confirmam a existência do eixo intestino-pele, onde a modulação dessa interação por prebióticos e probióticos pode promover benefícios à saúde da pele. Consideraçoes finais: este trabalho contribui para pesquisas futuras, a fim de elucidar os mecanismos subjacentes às interações microbianas intestino-pele, especialmente para a formulação de novas estratégias e intervenções para prevenir envelhecimento prematuro da pele, retardar o envelhecimento cronológico de forma saudável e preservar a saúde da pele.
A IMPORTÂNCIA DA TECNOLOGIA NA FORMAÇÃO DE PROFESSORES NO SÉCULO XXI
Authors: Mota Maria Fabrícia Alves , Lopes Ana Gleice Rocha , Gomes Antonio José Ferreira , Miorando Carine Juliane Priebe , Sousa Ingraça Ferreira de , Lopes Maria Inês Coradini 
Published: November 2024

Este estudo investigou a importância da tecnologia na formação de professores no século XXI, destacando os desafios, as estratégias de capacitação e os impactos dessa transformação no processo educacional. O objetivo geral foi analisar como as tecnologias influenciam a formação docente e como os professores têm se adaptado às novas demandas educacionais. A pesquisa foi conduzida por meio de uma revisão bibliográfica, utilizando fontes acadêmicas, livros e artigos especializados. A análise indicou que as tecnologias, como plataformas de e-learning, MOOCs e Ambientes Virtuais de Aprendizagem (AVAs), têm contribuído para a personalização do ensino, o desenvolvimento de habilidades tecnológicas e o aprimoramento das práticas pedagógicas. No entanto, identificaram-se barreiras, como a falta de infraestrutura, a resistência dos professores e a escassez de formação específica, que dificultam a plena integração das tecnologias na formação docente. As considerações finais apontaram que a tecnologia desempenha uma função primordial na formação de professores, mas exige planejamento adequado, suporte contínuo e uma infraestrutura eficiente para ser implementada. A pesquisa também sugeriu a necessidade de estudos futuros que explorem as realidades educacionais diversas e como as tecnologias podem ser integradas aos currículos de formação de professores.
The return to 1980 stratospheric halogen levels: a moving target in ozone assessments from 2006 to 2022
Authors: Lickley Megan J. , Daniel John S. , McBride Laura A. , Salawitch Ross J. , Velders Guus J. M. 
Published: November 2024

Abstract. The international scientific assessment of ozone depletion is prepared every 4 years to support decisions made by the parties to the Montreal Protocol. In each assessment an outlook of ozone recovery time is provided. The year when equivalent effective stratospheric chlorine (EESC) returns to the level found in 1980 is an important metric for the recovery of the ozone layer. Over the past five assessments, the expected date for the return of EESC to the 1980 level, for mid-latitudes, was delayed, from the year 2049 in the 2006 assessment to 2066 in the 2022 assessment, which represents a delay of 17 years over a 16-year assessment period. Here, we quantify the primary drivers that have delayed the expected EESC recovery date between each of these assessments. We find that by using identical EESC formulations, the delay between the 2006 and 2022 assessments' expected return of EESC to 1980 levels is shortened to 12.6 years. Of this delay, bank calculation methods account for ∼ 4 years, changes in the assumed atmospheric lifetime for certain ozone-depleting substances (ODSs) account for ∼ 3.5 years, an underestimate of the emission of carbon tetrachloride accounts for ∼ 3 years, and updated historical mole fraction estimates of ODSs account for ∼ 1 year. Since some of the underlying causes of these delays are amenable to future controls (e.g., capture of ODSs from banks and limitations on future feedstock emissions), it is important to understand the reasons for the delays in the expected recovery date of stratospheric halogens.
Precise dating of deglacial Laptev Sea sediments via 14C and authigenic 10Be∕9Be – assessing local 14C reservoir ages
Authors: Nicolas Arnaud , Mollenhauer Gesine , Lachner Johannes , Stübner Konstanze , Malter Maylin , Wollenburg Jutta , Grotheer Hendrik , Adolphi Florian 
Published: November 2024

Abstract. Establishing accurate chronological frameworks is imperative for reliably identifying lead–lag dynamics within the climate system and enabling meaningful intercomparisons across diverse paleoclimate proxy records over long time periods. Robust age models provide a solid temporal foundation for establishing correlations between paleoclimate records. One of the primary challenges in constructing reliable radiocarbon-based chronologies in the marine environment is to determine the regional marine radiocarbon reservoir age correction. Calculations of the local marine reservoir effect (ΔR) can be acquired using independent 14C dating methods, such as synchronization with other well-dated archives. The cosmogenic radionuclide 10Be offers such a synchronization tool. Its atmospheric production rate is controlled by the global changes in the cosmic ray influx, caused by variations in solar activity and geomagnetic field strength. The resulting fluctuations in the meteoric deposition of 10Be are preserved in sediments and ice cores and can thus be utilized for their synchronization. In this study, for the first time, we use the authigenic 10Be/9Be record of a Laptev Sea sediment core for the period 8–14 kyr BP and synchronize it with the 10Be records from absolutely dated ice cores. Based on the resulting absolute chronology, a benthic ΔR value of +345 ± 60 14C years was estimated for the Laptev Sea, which corresponds to a marine reservoir age of 848 ± 90 14C years. The ΔR value was used to refine the age–depth model for core PS2458-4, establishing it as a potential reference chronology for the Laptev Sea. We also compare the calculated ΔR value with modern estimates from the literature and discuss its implications for the age–depth model.
Topographic stresses affect stress changes caused by megathrust earthquakes and condition aftershock seismicity in forearcs: Insights from mechanical models and the Tohoku-Oki and Maule earthquakes
Authors: Dielforder Armin , Bocchini Gian Maria , Hampel Andrea 
Published: November 2024

Abstract. Aftershocks of megathrust earthquakes at subduction zones may be driven by stresses arising from the topography of the forearc. However, the effect of topographic stresses on aftershock triggering is quantitatively not well understood and has been neglected in Coulomb failure stress models that assess whether the stress change caused by an earthquake promotes or inhibits failure on nearby faults. Here we use analytical and numerical models to examine the importance of topographic stresses on stress changes caused by megathrust earthquakes in the forearc. We show that the superposition of topographic and tectonic stresses leads to a dependence of the stress change on the stress state of the forearc. The dependence on the forearc stress state largely determines the coseismic stress change induced by a megathrust earthquake and must be considered when calculating Coulomb failure stress changes. We further show that increases in Coulomb failure stress promoting widespread failure in the forearc are only possible if topographic stresses dominate the regional stress field after the megathrust earthquake. Applying our modelling approach to the 2011 Mw 9.0 Tohoku-Oki and 2010 Mw 8.8 Maule megathrust earthquakes shows that the effect of topographic stresses caused Coulomb failure stress changes of up to ~40 MPa, which promoted the majority of aftershocks in the Japanese and Chilean forearcs. The model results further reveal that the spatial distribution of aftershocks was influenced by local differences in pre-earthquake stress states, fault strength and megathrust stress drop. Our analysis highlights the significance of topographic stresses in Coulomb failure stress calculations, enabling a better estimation of seismic hazard at subduction zones.
Understanding the impact of data gaps on long-term offshore wind resource estimates
Authors: Jonietz Alvarez Martin Georg , Watson Warren , Gottschall Julia 
Published: November 2024

Abstract. In the context of a wind farm project, the wind resource is assessed to predict the power output and the optimal positioning of wind turbines. This requires taking wind measurements on the site of interest and extrapolating these to the long term using so-called “measure, correlate, and predict” (MCP) methods. Sensor, power supply, and software failures are common phenomena. These disruptions cause gaps in the measured data, which can especially be long in offshore measurement campaigns due to harsh weather conditions causing system failures and preventing servicing and redeployment. The present study investigates the effect of measurement data gaps on long-term offshore wind estimates by analyzing the bias they introduce in the parameters commonly used for wind resource assessment. Furthermore, it aims to show how filling the gaps can mitigate their effect. To achieve this, we perform investigations for three offshore sites in Europe with 2 years of concurrent measurements. We use reanalysis data and various MCP methods to fill gaps in the measured data and extrapolate these data to the long term. Current standards demand high data availability (80 % or 90 %) for wind measurement campaigns, so we expect that the effect of missing data on the uncertainty in long-term extrapolations is of the same order of magnitude as other uncertainty components such as the measurement uncertainty or the inter-annual variability. Nevertheless, our results show that the effects of gaps are considerably smaller than the other uncertainty components. For instance, gaps of 180 d cause an average deviation of the long-term mean wind speed of less than 0.04 m s−1 and a 95th percentile deviation of less than 0.075 m s−1 for all tested sites. Due to the low impact of gaps, gap filling does not have the potential to significantly reduce the uncertainty in the long-term extrapolation.
La transición infinita. La “insurrección oligárquica” contra el Estado Plurinacional
Authors: Bautista S. Rafael 
Published: November 2024

El golpe que se dio en Bolivia en octubre de 2019 no puede ser abordado como si se tratara de un “golpe clásico”, sino que se inscribe en la nueva definición conceptual de lo que significa un “golpe suave”, al interior de la terminología que usa el “smart power” imperial. Fue planificado como una “revolución de colores” pensada para implosionar procesos democráticos desde adentro. Precisamente la novedad de esta modalidad golpista es uno de los factores que descolocó a muchos analistas, pues si lo que se tiene es una idea clásica de “golpe”, mal se puede entender este tipo de modalidad que el Imperio ha desarrollado para ejercer un nuevo tipo de control y dominación de su ámbito periférico. En ese sentido, la definición de “transición infinita” quiere señalar el carácter embaucador que usó el gobierno golpista para autodefinirse como “de transición” cuando, en los hechos, se atribuyó un comportamiento estatal que desdecía su pretendido carácter transitorio.
Does Tranexamic Acid Improve Early Postoperative Shoulder Motion After Total Shoulder Arthroplasty?
Authors: Wright Logan T. , Cueto Robert J. , Hao Kevin A. , Popp Reed , Hartman Joseph B. , Hones Keegan M. , Wright Jonathan O. , Wright Thomas W. , Farmer Kevin W. , LaMonica Tyler J. , Schoch Bradley S. , King Joseph J. 
Published: November 2024

Purpose:
Although the hematologic benefits of tranexamic acid (TXA) have been thoroughly evaluated, an additional value demonstrated in knee arthroplasty and rotator cuff repair is improved early postoperative range of motion (ROM). This study aims to evaluate whether TXA given during total shoulder arthroplasty (TSA) confers improved early postoperative ROM or pain.

Methods:
We did retrospective review of 653 TSAs (223 anatomic TSA [aTSA] and 430 reverse TSA [rTSA]) performed in 596 patients at a single institution from 2007 to 2022. Intraoperative TXA use was implemented on a case-by-case basis starting in 2014 then became standard practice in 2016. Pre- to postoperative improvement in ROM was evaluated at 6 weeks, 3 months, 6 months, 1 year, and 2-years of follow-up. Mixed-effects models were used to evaluate whether administration of TXA intraoperatively improved ROM or pain at each follow-up time point.

Results:
TXA was administered to 26% (n = 58) of aTSAs and 43% (n = 179) of rTSAs. Patients with a history of hypertension received TXA at a higher rate for both aTSA (P = 0.009) and rTSA (P = 0.005). Intraoperative TXA was not associated with improved ROM or pain for aTSA or rTSA at any time point investigated. Average estimated intraoperative blood loss was markedly less in the TXA group for both aTSA [250 to 300 mL] (P < 0.001) and rTSA [200 to 300 mL] (P < 0.001) when compared with the non-TXA groups [300 to 400 mL for both].

Conclusion:
Intraoperative TXA does not improve ROM or pain after TSA. However, intraoperative blood loss was reduced, further supporting the routine use of TXA to reduce hematologic complications and improve intraoperative visibility.
Descriptores de la precipitación de la cuenca del río cachi de Ayacucho
Authors: Pereda Alex , Jiménez Julio , Ramírez Denlis , Tairo Ruth 
Published: November 2024

El estudio, expone los descriptores de la precipitación observados en la cuenca del río Cachi, durante 1991 al 2008, por la naturaleza de su desarrollo, es cuantitativa descriptiva, no experimental, longitudinal, actuada sobre una serie cronológica de 3016 registros de la precipitación mensual en 22 estaciones hidrometeorológicas administradas por el Gobierno Regional de Ayacucho. Los datos fueron organizados en Excel y procesados en SPSS, luego se realizó el análisis de varianza, aplicando la estadística descriptiva y las comparaciones múltiples de Duncan, observándose que al menos uno de los promedios de la precipitación mensual es diferente de los otros. Los resultados revelaron que, de 1991 al 1999, la precipitación mensual promedio en la cuenca presentó pequeñas variaciones cíclicas que denota fluctuación de un nivel muy bajo a uno ligeramente alto, a excepción del año 1993 con una precipitación acentuada en un nivel alto. En los demás años del periodo, la precipitación muestra mayor variación con picos pronunciados ubicados en un nivel alto y muy alto; además, en los meses de verano la precipitación mensual media es la más alta del año, en los demás meses es muy baja, en especial en los meses de mayo a julio; asimismo, se determinó que la precipitación en la Cuenca Alta varía de 18.97 a 98.00 mm y en la Cuenca Media oscila de 43.92 a 97.90 mm. Con estas estimaciones no se cumple la relación inversa entre la precipitación y la altitud de estación.
Impact of anxiety symptoms on dialysis adherence and complication rates: A longitudinal observational study
Authors: Huang Peng , Huang Hai-Ting , Ma Jing , Pang Jun , Zhang Yu-Yuan , Ma Chun-Hui , Wang Si-Dan , Liang Xiong-Zhuang , Wang Jie 
Published: November 2024

BACKGROUND
Anxiety is a common psychological comorbidity in patients undergoing dialysis, yet its impact on treatment adherence and complication rates remains understudied. We designed a longitudinal observational study to investigate these relationships, based on the hypothesis that higher anxiety symptoms would be associated with increased complication rates and negatively associated with adherence to the dialysis regimen.
AIM
To investigate the relationship between anxiety symptoms, dialysis adherence, and complication rates in patients undergoing dialysis over a 24-month period.
METHODS
This observational study analyzed data from 250 adult patients who underwent hemodialysis or peritoneal dialysis at three Affiliated Hospitals of Youjiang Medical University for Nationalities over a period of 24 months. Anxiety symptoms were assessed using the Hospital Anxiety and Depression Scale-Anxiety subscale at baseline and every 6 months. Dialysis adherence was evaluated through attendance records, interdialytic weight gain, and patient-reported medication adherence. We recorded complications (infections, cardiovascular events, and hospitalizations) and used mixed-effects models and survival analyses to infer associations between anxiety symptoms, adherence measures, and complication rates.
RESULTS
Higher anxiety symptoms were significantly associated with poorer dialysis adherence, including increased missed sessions [incidence rate ratio = 1.32, 95% confidence interval (CI): 1.18-1.47, P < 0.001], greater interdialytic weight gain (β = 0.24, 95%CI: 0.15-0.33, P < 0.001), and lower medication adherence (odds ratio = 0.85, 95%CI: 0.78-0.93, P < 0.001). Patients with clinically significant anxiety (Hospital Anxiety and Depression Scale-Anxiety subscale ≥ 8) had a higher risk of complications [hazard ratio (HR) = 1.68, 95%CI: 1.32-2.14, P < 0.001], particularly infections (HR = 1.89, 95%CI: 1.41-2.53, P < 0.001) and cardiovascular events (HR = 1.57, 95%CI: 1.18-2.09, P = 0.002). The relationship between anxiety and complications was partially mediated by adherence measures.
CONCLUSION
Anxiety symptoms in patients undergoing dialysis are associated with poorer treatment adherence and increased complication rates. Regular screening and targeted interventions to address symptoms may improve adherence and clinical outcomes.