bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glyphosate-Resistant Junglerice (Echinochloa colona) from Mississippi and Tennessee: Magnitude and Resistance Mechanisms
Authors: Nandula Vijay K. , Montgomery Garret B. , Vennapusa Amaranatha R. , Jugulam Mithila , Giacomini Darci A. , Ray Jeffery D. , Bond Jason A. , Steckel Lawrence E. , Tranel Patrick J. 
Published: September 2018

AbstractRecently, several incidents of glyphosate failure on junglerice [Echinochloa colona(L.) Link] have been reported in the midsouthern United States, specifically in Mississippi and Tennessee. Research was conducted to measure the magnitude of glyphosate resistance and to determine the mechanism(s) of resistance to glyphosate inE. colonapopulations from Mississippi and Tennessee. ED50(dose required to reduce plant growth by 50%) values for a resistant MSGR4 biotype, a resistant TNGR population, and a known susceptible MSGS population were 0.8, 1.62, and 0.23 kg ae ha−1of glyphosate, respectively. The resistance index calculated from the these ED50values indicated that the MSGR4 biotype and TNGR population were 4- and 7-fold, respectively, resistant to glyphosate relative to the MSGS population. The absorption patterns of [14C]glyphosate in the TNGR and MSGS populations were similar. However, the MSGS population translocated 13% more [14C]glyphosate out of the treated leaf compared with the TNGR population at 48 h after treatment.EPSPSgene sequence analyses of TNGRE. colonaindicated no evidence of any point mutations, but several resistant biotypes, including MSGR4, possessed a single-nucleotide substitution of T for C at codon 106 position, resulting in a proline-to-serine substitution (CCA to TCA). Results from quantitative polymerase chain reaction analyses suggested that there was no amplification of theEPSPSgene in the resistant populations and biotypes. Thus, the mechanism of resistance in the MSGR population (and associated biotypes) is, in part, due to a target-site mutation at the 106 loci of theEPSPSgene, while reduced translocation of glyphosate was found to confer glyphosate resistance in the TNGR population.
Seismic Evidence for Tectonically Dominated Seafloor Spreading in the Southwest Sub‐basin of the South China Sea
Authors: Yu Junhui , Yan Pin , Wang Yanlin , Zhang Jinchang , Qiu Yan , Pubellier Manuel , Delescluse Matthias 
Published: September 2018

AbstractSeafloor spreading can be explained by different dynamic mechanisms, magmatically or tectonically dominated. The Southwest Sub‐basin, located at the southwest tip of the propagating seafloor spreading of the South China Sea, remains unclear for its spreading regime owing to poor and debated knowledge of the crustal structures. Here two multichannel seismic lines and one oceanic bottom seismometer line across this subbasin are reprocessed and analyzed with focus on crustal imaging. The sediments are usually 0.5–1.0 km thick over the abyssal basin and slightly thicker in the few grabens. The thickest (3.3 km) sediments are found in the fossil spreading center. The basement is fairly rough and highly faulted by ubiquitous crustal faults. The fossil spreading center is characterized by a deep median valley, similar to that of magma‐poor spreading cases. Both multichannel seismic lines show a few intermittent and diffusive reflectors at 1.5‐ to 3.6‐km depth below the fragmented basement. These reflectors, correlating well with the velocities of 6.8–7.2 km/s obtained from velocity inversion of oceanic bottom seismometer data, are interpreted as Moho reflections. Thus, the inferred crustal thickness is only 1.5–3.6 km excluding the sediments, which is much thinner than usual. The underlying mantle with velocities lower than 8.0 km/s might be serpentinized with water infiltration along these crustal faults. Therefore, it is proposed that the spreading of the Southwest Sub‐basin was tectonically dominated.
Data Constraints on Glacial Atlantic Water Mass Geometry and Properties
Authors: Oppo Delia W. , Gebbie Geoffrey , Huang Kuo‐Fang , Curry William B. , Marchitto Thomas M. , Pietro Kathryn R. 
Published: September 2018

AbstractThe chemical composition of benthic foraminifera from marine sediment cores provides information on how glacial subsurface water properties differed from modern, but separating the influence of changes in the origin and end‐member properties of subsurface water from changes in flows and mixing is challenging. Spatial gaps in coverage of glacial data add to the uncertainty. Here we present new data from cores collected from the Demerara Rise in the western tropical North Atlantic, including cores from the modern tropical phosphate maximum at Antarctic Intermediate Water (AAIW) depths. The results suggest lower phosphate concentration and higher carbonate saturation state within the phosphate maximum than modern despite similar carbon isotope values, consistent with less accumulation of respired nutrients and carbon, and reduced air‐sea gas exchange in source waters to the region. An inversion of new and published glacial data confirms these inferences and further suggests that lower preformed nutrients in AAIW, and partial replacement of this still relatively high‐nutrient AAIW with nutrient‐depleted, carbonate‐rich waters sourced from the region of the modern‐day northern subtropics, also contributed to the observed changes. The results suggest that glacial preformed and remineralized phosphate were lower throughout the upper Atlantic, but deep phosphate concentration was higher. The inversion, which relies on the fidelity of the paleoceanographic data, suggests that the partial replacement of North Atlantic sourced deep water by Southern Ocean Water was largely responsible for the apparent deep North Atlantic phosphate increase, rather than greater remineralization.
Quantifying single plasmonic nanostructure far-fields with interferometric and polarimetric k-space microscopy
Authors: Röhrich Ruslan , Hoekmeijer Chris , Osorio Clara I. , Koenderink A. Femius 
Published: September 2018

AbstractOptically resonant nanoantennae are key building blocks for metasurfaces, nanosensors, and nanophotonic light sources due to their ability to control the amplitude, phase, directivity, and polarization of scattered light. Here, we report an experimental technique for the full recovery of all degrees of freedom encoded in the far-field radiated by a single nanostructure using a high-NA Fourier microscope equipped with digital off-axis holography. This method enables full decomposition of antenna-physics in its multipole contributions and gives full access to the orbital and spin angular momentum properties of light scattered by single nano-objects. Our results demonstrate these capabilities through a quantitative assessment of the purity of the “selection rules” for orbital angular momentum transfer by plasmonic spiral nanostructures.
Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation
Authors: Cai Helen Q. , Catts Vibeke S. , Webster Maree J. , Galletly Cherrie , Liu Dennis , O’Donnell Maryanne , Weickert Thomas W , Weickert Cynthia Shannon 
Published: September 2018

AbstractElevated pro-inflammatory cytokines exist in both blood and brain of people with schizophrenia but how this affects molecular indices of the blood–brain barrier (BBB) is unclear. Eight mRNAs relating to BBB function, a microglia and three immune cell markers were measured by qPCR in the prefrontal cortex from 37 people with schizophrenia/schizoaffective disorder and 37 matched controls. This cohort was previously grouped into “high inflammation” and “low inflammation” subgroups based on cortical inflammatory-related transcripts. Soluble intercellular adhesion molecule-1 (sICAM1) was measured in the plasma of 78 patients with schizophrenia/schizoaffective disorder and 73 healthy controls. We found that sICAM1 was significantly elevated in schizophrenia. An efflux transporter, ABCG2, was lower, while mRNAs encoding VE-cadherin and ICAM1 were higher in schizophrenia brain. The “high inflammation” schizophrenia subgroup had lower ABCG2 and higher ICAM1, VE-cadherin, occludin and interferon-induced transmembrane protein mRNAs compared to both “low inflammation” schizophrenia and “low inflammation” control subgroups. ICAM1 immunohistochemistry showed enrichment in brain endothelium regardless of diagnosis and was localised to astrocytes in some brains. Microglia mRNA was not altered in schizophrenia nor did it correlate with ICAM1 expression. Immune cell mRNAs were elevated in “high inflammation” schizophrenia compared to both “low inflammation” schizophrenia and controls. CD163+ perivascular macrophages were identified by immunohistochemistry in brain parenchyma in over 40% of “high inflammation” schizophrenia brains. People with high levels of cytokine expression and schizophrenia display changes consistent with greater immune cell transmigration into brain via increased ICAM1, which could contribute to other neuropathological changes found in this subgroup of people.
γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential
Authors: Alvarado-Kristensson Maria 
Published: September 2018

AbstractKnowledge of γ-tubulin is increasing with regard to the cellular functions of this protein beyond its participation in microtubule nucleation. γ-Tubulin expression is altered in various malignancies, and changes in theTUBG1gene have been found in patients suffering from brain malformations. This review recapitulates the known functions of γ-tubulin in cellular homeostasis and discusses the possible influence of the protein on disease development and cancer.
The MYB/miR-130a/NDRG2 axis modulates tumor proliferation and metastatic potential in salivary adenoid cystic carcinoma
Authors: Wang Yu , Zhang Chun-ye , Xia Rong-hui , Han Jing , Sun Bao , Sun Shu-yang , Li Jiang 
Published: September 2018

AbstractIncreasing evidence has emerged to suggest that N-myc downstream-regulated gene 2 (NDRG2) dysregulation participates in a number of tumor biological processes. However, the role of NDRG2 and miRNA-mediated NDRG2 regulation in salivary adenoid cystic carcinoma (SACC) progression remain unknown. Here, we determined that SACC tissues exhibited decreased level of NDRG2, which was associated with poorer rates of overall survival and distant metastasis-free survival. Silencing NDRG2 promoted SACC cell proliferation and metastasis both in vitro and in vivo. MiRNAs have been reported as vital regulators of NDRG2 expression. Based on micronome sequencing of three paired samples of SACC and normal salivary gland tissue and on an online database analysis, miR-130a was identified as a candidate miRNA that potentially regulates NDRG2. We demonstrated that the expression level of NDRG2 was dramatically reduced by exogenous miR-130a. Moreover, a luciferase assay further validated that miR-130a could degrade NDRG2 mRNA by targeting sites in the NDRG2 3′UTR. A rescue experiment suggested that NDRG2 expression could reverse the miR-130a-mediated promotion of cell proliferation and invasion. The expression of miR-130a has been reported to be regulated by certain transcription factors. In the preset study, we verified that the transcription factor MYB acted as the critical driver in SACC-upregulated miR-130a expression directly and induced NDRG2 downregulation in SACC tissues. Additionally, MYB/miR-130a activated the STAT3 and AKT pathways by downregulating NDRG2. These observations suggest that the MYB/miR-130a/NDRG2 axis, which modulates proliferation and metastasis in SACC, provides promising targets for the treatment of SACC.
CDK4 inhibition diminishes p53 activation by MDM2 antagonists
Authors: Sriraman Anusha , Dickmanns Antje , Najafova Zeynab , Johnsen Steven A. , Dobbelstein Matthias 
Published: September 2018

AbstractThe genes encoding MDM2 and CDK4 are frequently co-amplified in sarcomas, and inhibitors to both targets are approved or clinically tested for therapy. However, we show that inhibitors of MDM2 and CDK4 antagonize each other in their cytotoxicity towards sarcoma cells. CDK4 inhibition attenuates the induction of p53-responsive genes upon MDM2 inhibition. Moreover, the p53 response was also attenuated when co-depleting MDM2 and CDK4 with siRNA, compared to MDM2 single knockdown. The complexes of p53 and MDM2, as well as CDK4 and Cyclin D1, physically associated with each other, suggesting direct regulation of p53 by CDK4. Interestingly, CDK4 inhibition did not reduce p53 binding or histone acetylation at promoters, but rather attenuated the subsequent recruitment of RNA Polymerase II. Taken together, our results suggest that caution must be used when considering combined CDK4 and MDM2 inhibition for patient treatment. Moreover, they uncover a hitherto unknown role for CDK4 and Cyclin D1 in sustaining p53 activity.
Anterior-posterior gradient of plasticity in primate prefrontal cortex
Authors: Riley Mitchell R. , Qi Xue-Lian , Zhou Xin , Constantinidis Christos 
Published: September 2018

AbstractThe functional organization of the primate prefrontal cortex has been a matter of debate with some models speculating dorso-ventral and rostro-caudal specialization while others suggesting that information is represented dynamically by virtue of plasticity across the entire prefrontal cortex. To address functional properties and capacity for plasticity, we recorded from different prefrontal sub-regions and analyzed changes in responses following training in a spatial working memory task. This training induces more pronounced changes in anterior prefrontal regions, including increased firing rate during the delay period, selectivity, reliability, information for stimuli, representation of whether a test stimulus matched the remembered cue or not, and variability and correlation between neurons. Similar results are obtained for discrete subdivisions or when treating position along the anterior-posterior axis as a continuous variable. Our results reveal that anterior aspects of the lateral prefrontal cortex of non-human primates possess greater plasticity based on task demands.
A zeolitic vanadotungstate family with structural diversity and ultrahigh porosity for catalysis
Authors: Zhang Zhenxin , Zhu Qianqian , Sadakane Masahiro , Murayama Toru , Hiyoshi Norihito , Yamamoto Akira , Hata Shinichi , Yoshida Hisao , Ishikawa Satoshi , Hara Michikazu , Ueda Wataru 
Published: September 2018

AbstractDesign of the structure and composition of crystalline microporous inorganic oxides is of great importance in catalysis. Developing new zeolites is one approach towards this design because of the tunable pore system and high thermal stability. Zeolites are limited to main group elements, which limits their applications in redox catalysis. Another promising choice is zeolitic transition metal oxides providing both porosity and redox activity, thereby further expanding the diversity of porous materials. However, the examples of zeolitic transition metal oxides are rare. Here, we report a new class of zeolitic vanadotungstates with tunable frameworks exhibiting a large porosity and redox activity. The assembly of [W4O16]8− units with VO2+ forms two isomeric porous frameworks. Owing to the complex redox properties and open porosity, the vanadotungstates efficiently catalyse the selective reduction of NO by NH3. This finding provides an opportunity for design and synthesis of inorganic multifunctional materials for future catalytic applications.
Effectiveness of mesenchymal stem cells for treating patients with knee osteoarthritis: a meta-analysis toward the establishment of effective regenerative rehabilitation
Authors: Iijima Hirotaka , Isho Takuya , Kuroki Hiroshi , Takahashi Masaki , Aoyama Tomoki 
Published: September 2018

AbstractThis systematic review with a meta-analysis aimed to summarize the current evidence of the effectiveness of mesenchymal stem cell (MSC) treatment for knee osteoarthritis (OA) and to examine whether rehabilitation is an effect modifier of the effect estimate of MSC treatment. A literature search yielded 659 studies, of which 35 studies met the inclusion criteria (n = 2385 patients; mean age: 36.0–74.5 years). The meta-analysis results suggested that MSC treatment through intra-articular injection or arthroscopic implantation significantly improved knee pain (standardized mean difference [SMD]: −1.45, 95% confidence interval [CI]: −1.94, −0.96), self-reported physical function (SMD: 1.50, 95% CI: 1.09, 1.92), and cartilage quality (SMD: −1.99; 95% CI: −3.51, −0.47). However, the MSC treatment efficacy on cartilage volume was limited (SMD: 0.49; 95% CI: −0.19, 1.16). Minor adverse events (knee pain or swelling) were reported with a wide-ranging prevalence of 2–60%; however, no severe adverse events occurred. The evidence for these outcomes was “very low” to “low” according to the Grades of Recommendation, Assessment, Development and Evaluation system because of the poor study design, high risk of bias, large heterogeneity, and wide 95% CI of the effects estimate. Performing rehabilitation was significantly associated with better SMD for self-reported physical function (regression coefficient: 0.881, 95% CI: 0.049, 1.712; P = 0.039). We suggest that more high quality randomized controlled trials with consideration of the potential rehabilitation-driven clinical benefit would be needed to facilitate the foundation of effective MSC treatment and regenerative rehabilitation for patients with knee OA.
Context-dependent prediction of protein complexes by SiComPre
Authors: Rizzetto Simone , Moyseos Petros , Baldacci Bianca , Priami Corrado , Csikász-Nagy Attila 
Published: September 2018

AbstractMost cellular processes are regulated by groups of proteins interacting together to form protein complexes. Protein compositions vary between different tissues or disease conditions enabling or preventing certain protein−protein interactions and resulting in variations in the complexome. Quantitative and qualitative characterization of context-specific protein complexes will help to better understand context-dependent variations in the physiological behavior of cells. Here, we present SiComPre 1.0, a computational tool that predicts context-specific protein complexes by integrating multi-omics sources. SiComPre outperforms other protein complex prediction tools in qualitative predictions and is unique in giving quantitative predictions on the complexome depending on the specific interactions and protein abundances defined by the user. We provide tutorials and examples on the complexome prediction of common model organisms, various human tissues and how the complexome is affected by drug treatment.
Pepper mild mottle virus as a water quality indicator
Authors: Kitajima Masaaki , Sassi Hannah P. , Torrey Jason R. 
Published: September 2018

AbstractPepper mild mottle virus (PMMoV) was recently found to be the most abundant RNA virus in human feces, and is a plant virus belonging to the genus Tobamovirus in the family Virgoviridae. When in human feces, it is of dietary origin from peppers and their processed products, and is excreted from a large proportion of healthy human populations, but rarely found in animal feces. Over the past decade, this virus has been increasingly attracting research attention as a potential viral indicator for human fecal pollution in aquatic environments and water treatment systems. Results presented in the literature reveal that PMMoV is globally distributed and present in various water sources in greater abundance than human pathogenic viruses, without substantial seasonal fluctuations. Several studies report that increased concentrations of PMMoV tend to be correlated with increased fecal contamination in general, along with more frequent detection of pathogenic enteric viruses. PMMoV also exhibits remarkable stability in water under various environmental conditions. Here, we review recent advancements in our understanding of the occurrence and persistence of PMMoV in natural and engineered water systems and discuss its advantages and limitations as a viral indicator for improved microbial water quality management.
The gastric mucosal-associated microbiome in patients with gastric polyposis
Authors: Ren Rongrong , Wang Zikai , Sun Huaibo , Gao Xuefeng , Sun Gang , Peng Lihua , Yan Bin , Yang Yunsheng 
Published: September 2018

AbstractThe characteristics of the gastric microbiota in patients with gastric polyposis (GP) remain unclear. Given this we collected gastric antrum and gastric body biopsies from healthy controls (HC.A and HC.B group) and gastric antrum, gastric body and polyp biopsies from patients with multiple gastric polyps (GP.A, GP.B and GP.P group) for 16S rDNA sequencing. The results showed that the diversity of the gastric flora in the GP group was significantly lower than that of the HC group. The gastric flora composition of the GP group was significantly different from the HC group. However, flora diversity and compositions in different parts of the stomach (gastric antrum, gastric body or polyp tissue) were not significantly different. H. pylori abundance could influence the composition of gastric microbiota. Meanwhile, patients with fundic gland polyps (FGPs) and those with hyperplastic polyps (HPs) had considerably similar gastric bacterial compositions. We constructed a microbial dysbiosis index (MDI) based on the gastric microbiota at the genus level as a predictive model, and it was able to distinguish between individuals in the GP and HC groups. These findings showed that intragastric flora dysbiosis may be closely related to the occurrence and development of gastric polyps.
Low fasting plasma glucose level as a predictor of new-onset diabetes mellitus on a large cohort from a Japanese general population
Authors: Ogata Emi , Asahi Koichi , Yamaguchi Satoshi , Iseki Kunitoshi , Sato Hiroaki , Moriyama Toshiki , Yamagata Kunihiro , Tsuruya Kazuhiko , Fujimoto Shouichi , Narita Ichiei , Konta Tsuneo , Kondo Masahide , Shibagaki Yugo , Kasahara Masato , Watanabe Tsuyoshi , Shimabukuro Michio 
Published: September 2018

AbstractAlthough fasting plasma glucose levels <70 mg/dL are associated with a high incidence of cardiovascular disease (CVD), whether there is any risk of new-onset diabetes mellitus owing to fasting plasma glucose at this range has not been clarified. We measured the odds ratio (OR) of new-onset diabetes mellitus relative to fasting plasma glucose levels at various ranges in a nation-wide Japanese population with and without CVD history. Of 186,749 participants without diabetes in 2008, 171,408 had no history of CVD, while 15,341 did. Participants were classified into 8 categories according to their fasting plasma glucose levels. Unadjusted and multivariable-adjusted logistic regression models were used to measure the OR of new-onset diabetes mellitus in the 3-year follow up. In all participants, multivariable-adjusted OR increased when fasting plasma glucose levels were <70 mg/dL or 90–125 mg/dL. Participants without CVD showed increased OR when glucose levels were <70 mg/dL or 90–125 mg/dL. Participants with a history of CVD showed increased OR with glucose levels of 95–125 mg/dL. The risk of new-onset diabetes mellitus is higher when fasting glucose levels are <70 mg/dL, indicating that the paradox of fasting glucose seeks a new risk stratification for new-onset diabetes mellitus.