bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum autotaxin positively associates with hypertension in postmenopausal women: a single center study in China
Authors: Zhang Jie , Wang Jiayi , Zhou Xuefeng , Chen Shurong , Li Yu , Ke Yini , Li Youming , Yu Chaohui , Chen Yi 
Published: November 2024

Aim:
Autotaxin is an adipokine involved in metabolic disorders. The aim of the current study was to evaluate serum autotaxin levels in hypertensive postmenopausal women and establish a relationship between autotaxin and other comorbidities in this special group.

Methods:
This single-center study included postmenopausal women who received annual health examinations at the First Affiliated Hospital, College of Medicine, Zhejiang University in Zhejiang, China. The metabolic and demographic characteristics of the subjects, including age, sex, height, weight, blood pressure, and biochemical indices, were collected. The serum autotaxin level was measured via ELISA. The Kolmogorov-Smirnov test, Student's t test, Mann–Whitney U test, χ
2 test, receiver operating characteristic (ROC) curve analysis, Spearman correlation analysis and multivariate logistic regression analysis were adopted for statistical analysis.

Results:
This pilot observational study included 25 hypertensive postmenopausal women and 25 age-matched normotensive controls. Hypertensive patients presented significant metabolic disturbances with greater comorbidities such as nonalcoholic fatty liver disease, obesity, overweight, diabetes, hypertriglyceridemia and hyperuricemia (P < 0.05), impaired renal health with higher uric acid levels (P < 0.001), and slightly elevated creatinine levels (P = 0.156) with lower estimated glomerular filtration rates (eGFRs) (P = 0.195). The serum autotaxin level was markedly greater in the hypertensive group (239.0±59.6 ng/ml vs. 192.7 ± 49.0 ng/ml; P < 0.01) and was positively associated with systolic blood pressure; diastolic blood pressure; and alanine transaminase, triglycerides (TG), creatinine, and uric acid levels and inversely associated with the eGFR (P < 0.05) among postmenopausal women. Serum autotaxin levels positively predicted hypertension, with an AU-ROC of 0.750 [95% confidence interval (CI): 0.613–0.888] and a Youden index of 0.480 at a cutoff of 225 ng/ml. In the multivariate logistic regression analysis, after adjustment for demographic and metabolic parameters (including age, BMI, ALT, TB, uric acid, FBG, TG, LDL and creatinine), autotaxin (ATX) remained independently positively correlated with the risk of hypertension [odds ratio: 1.016, 95% CI 1.001–1.031; P < 0.05).

Conclusions:
Among postmenopausal women, the serum autotaxin level is significantly elevated in the hypertensive group compared with age-matched normotensive controls. ATX is related to multiple metabolic disorders and renal health, suggesting that autotaxin has potential as a multiorgan therapeutic target for cardiovascular-metabolic-renal disorders.
Predictive Factors in Asymptomatic Bacteriuria Treatment
Authors: Yazdi Mona T. , Mahatanan Rattanaporn , Ho Caroline , Rovelsky Suzette 
Published: November 2024

Background
Asymptomatic bacteriuria (ASB) can often be inappropriately treated with antibiotics. The primary objective was to identify factors associated with antibiotic treatment of ASB. The secondary objective was to identify the prevalence of ASB treatment at our institution before and after Infectious Diseases Society of America (IDSA) updated Clinical Practice Guidelines for the Management of Asymptomatic Bacteriuria in 2019.
1

Methods
This is a retrospective chart review of adults admitted to a rural Veterans Affairs Hospital in White River Junction, Vermont, with culture confirmed bacteriuria. Those who did not meet National Healthcare Safety Network criteria for diagnosis of urinary tract infection were classified as having ASB.

Results
The prevalence of ASB treatment was 58% (n = 61/106). Patients older than 80 years had 3.73 increased odds of receiving antibiotics for ASB (adjusted odds ratio 3.73, 95% confidence interval 1.43–9.71 P < 0.01). Leukocytes >5/hpf on urinalysis (adjusted odds ratio 4.45, confidence interval 1.19–16.57, P = 0.03) was significantly associated with antibiotic treatment in ASB. There was no significant difference between ASB treatment before 2019 versus after 2019.

Conclusions
Predictors of clinicians treating ASB with antibiotics were most significant in patients older than 80 years and those with leukocytes >5/hpf on urinalysis. The 2019 IDSA guidance on avoiding antibiotic treatment for ASB was not well adopted to clinical practice for hospitalized patients at our institution.
Hazardous alcohol consumption is associated with an increased occurrence of falls among people with HIV in the PROSPER-HIV Study
Authors: dos Santos Andre P. , Willig Amanda L. , Ruderman Stephanie A. , Oliveira Vitor H.F. , Horvat Davey Christine , Buford Thomas W. , Long Dustin M. , Gripshover Barbara , Katundu Mari , Cleveland John D. , Crane Heidi M. , Fleming Julia , Burkholder Greer , Saag Michael S. , Webel Allison R. 
Published: November 2024

Objective:
Falls are a significant public health concern, particularly among older adults and people with HIV (PWH). This study examines the association between alcohol consumption and falls in PWH.

Methods:
The PROSPER-HIV study recruited PWH from four US sites. Participants were categorized based on Alcohol Use Disorders Identification Test Consumption (AUDIT-C) scores: none, nonhazardous, and hazardous drinking. Data collection included demographics, medical history [i.e. comorbidities, treated hypertension, estimated glomerular filtration rate (eGFR)], alcohol consumption using AUDIT-C, daily alcohol recall in grams, and self-reported falls over the previous year. Physical performance was measured using the Short Performance Physical Battery (SPPB). Statistical analyses included Pearson's correlation and Poisson regression models to estimate fall prevalence ratios, adjusting for confounders (SPPB, comorbidities, treated hypertension, and eGFR).

Results:
The study included 315 PWH, aged 52 ± 12 years, with 78% male participants. Thirty-three percentage were classified as nondrinking, 50% nonhazardous, and 17% hazardous drinking. Poisson regression showed a significantly higher risk of falls [prevalence ratio: 2.12, 95% confidence interval (CI) 1.11–4.03] and recurrent falls (prevalence ratio 3.54, 95% CI 1.21–10.3) among hazardous drinking compared with nonhazardous drinking, even after adjusting for confounders. The prevalence ratios for falls per daily intake in grams was not statistically significant.

Conclusion:
There is a significant association between hazardous alcohol consumption and increased fall risk in PWH using AUDIT-C but not when accessing recall of alcohol consumption in grams.
Clinical Results of Percutaneous Transhepatic Biliary Drainage With Different Hepatic Access and Methods in the Treatment of Obstructive Jaundice
Authors: Şahan Mehmet Hamdi , Akşamoğlu Melih 
Published: November 2024

Background:
Percutaneous transhepatic biliary drainage (PTBD) is a common procedure for biliary obstruction jaundice caused by biliary tract obstruction. PTBD can be performed using external or external-internal methods, by the right or left lobe approach. However, differences in both the method used and the hepatic approach may affect success rates and complications. Therefore, this study aimed to examine the outcomes and complications of PTBD and compare them according to different methods and hepatic approaches.

Methods:
Patients who underwent PTBD procedures in our interventional radiology department due to benign or malignant pathologies between March 2021 and March 2024 were included in the study. The diagnoses of the patients, and total and direct bilirubin values before and after the procedure were recorded. The clinical results and the complications of PTBD were compared statistically according to the hepatic approach and method. Univariate logistic regression analysis was performed to determine significant factors associated with PTBD success and complications.

Results:
Sixty patients were included in our study (32 men, 28 women; mean age: 67.14±13.61 y). The most common indication was malignant bile duct obstruction (90%). The obstruction was mostly at the level of the common bile duct (46.7%). The success rate of PTBD was the highest with the left-side external biliary drainage approach (left-side external biliary drainage, 81.2%; right-side internal-external biliary drainage, 77.8%; right-side external biliary drainage, 69.2%; P=0.596). The complication rate was higher for right-side access (right side 15.9%, left side 12.5%, P=0.744). Univariate logistic regression analysis revealed that PTBD success in females was 5 times higher than in males [Exp(B): 5.000, β: 1.609, P<0.05]. Univariate logistic regression analysis revealed that methods used, entry lobes, and entry levels did not significantly affect PTBD success and complication incidence (P>0.05).

Conclusion:
All approaches and methods used during PTBD were associated with low complications and high success rates. Nevertheless, external biliary drainage with right hepatic access has the lowest clinical success rate and a higher complication rate than the left-lobe approach. We observed that left-sided external biliary drainage was the most successful method and had fewer complications.
Clinico-Epidemiological Profile of Type II Diabetes Mellitus in India – A Multicentric Institutional-Based Survey
Authors: Kalra Pramila , Mohan Gurinder , Tiewsoh Iadarilang , Raveendra K R , Ravi Kiran M , Kumar Sreejith N , Ghosh Sujoy , Dharmalingam Mala , Bhattacharya Prasanta Kumar , Akanth R , Chitra S , Pandit Kaushik , Lyngdoh Monaliza , Subramani Prabhu , Mukhopadhyay Pradip , Thaman Richa Ghay , Chandey Manish , Ramakrishna B S , Holigi Sivaranjani , Jain Smitha , Sundararaman R , Vedantha Srinivas J , Sreejith Veena , Jamil M D , Rahman Shafiq , Elizabeth R Mercy , Sekhar Theertha , Sreelakshmi P R , Vempadapu Monika , Sharma Aditi , Singh Reetu , Odedra Karan 
Published: November 2024

ABSTRACTBackgroundThe epidemic of diabetes mellitus is one of the leading causes of mortality globally. Therefore, the goal of the registry is to create a database on individuals with diabetes mellitus that may be utilized to provide data on the clinico-epidemiological profile of Diabetes Mellitus in the real world.MethodsData for this registry is captured at seven sites across India recognized by the Biotechnology Industry Research Assistance Council (BIRAC). This observational multi-centric study registered around 25077 Diabetic patients over three years (December 2023).ResultsOut of 25077 patients, 12793 (51%) were male and 12284 (49%) females. There were 11443 (46%) rural patients and 13575 (54%) urban patients. Most patients registered were over 50 years old (74.05±2.42). Diabetes was seen as a burden for 46% of individuals and their families. Less than 40% of patients exercised. Over half of the patients had a family history of diabetes. This explains the exponential rise of diabetes mellitus over generations and the significance of preventing it.ConclusionThis registry revealed the impact of the clinico-epidemiological aspects of Diabetes Mellitus on a larger number of samples. Future healthcare planners, researchers, and government officials will benefit from this diabetes registry in developing primary and secondary preventive initiatives that might minimize the rising healthcare burden of diabetes.
Exploratory analysis of cumulative fatigue derived from volume and intensity indicators in stage races of professional cycling
Authors: Machado AS. , De la Fuente C. , Javaloyes A. , Moya-Ramón M. , Mateo-March M. , Carpes FP. 
Published: November 2024

SummaryObjectiveHere, we discuss cumulative fatigue based on volume and power output from 12 professional male cyclists during two consecutive editions of the Giro d’Italia.MethodsVolume and power output were recorded and described according to time at different intensity zones based on power output (Z0 lower to Z7 higher). Correlations, principal component analysis (PCA), Gaussian clustering, and two-way ANOVA were performed (type error I of 5%).ResultsThe higher intensity zones elicited higher power output in those shorter stages (R2= 0.54). In contrast, the lower intensity zones were predominant in longer stages. The time spent in Z1 to Z3 (r = 0.67, 0.84, and 0.73) correlated more with stage’s volume duration than time in Z4 to Z7 (r = 0.48, 0.44, and 0.51, and 0.38). The normalized volume declined between stages 2 to 4, 8 to 10, 13 to 15, and 18 to 19. Negative slopes of time spent in Z4 and Z6 occurred one or two stages before Z1 presented negative slopes. In contrast, positive slopes of higher intensity zones were observed with a negative slope of Z1. Different clusters distributions of time volume to complete the grand tour were found (p<0.05). Finally, average power in Z1, Z2, Z3, Z4, Z5, Z6, and Z7 explained 63.62%, 18.20%, 8.12%, 5.84%, 2.98%, 1.20%, and 0.02% of the total variance in the normalized time volume, respectively. Volume and power zone data can recognize cumulative fatigue and performance recovery during a grand tour. Rest days favored the performance recovery, mostly the second rest day.
DEVELOPING NEW DUAL-ACTION ANTIVIRAL/ANTI-INFLAMMATORY SMALL MOLECULES FOR COVID-19 TREATMENT USING IN SILICO AND IN-VITRO APPROACHES
Authors: Ivanov Vladimir V. , Zakharov Anton B. , Anokhin Dmytro O. , Mykhailenko Olha O. , Kovalenko Sergiy M. , Yevsieieva Larysa V. , Georgiyants Victoriya A. , Korinek Michal , Chen Yu-Li , Fang Shu-Yen , El-Shazly Mohamed , Hwang Tsong-Long , Kalugin Oleg M. 
Published: November 2024

AbstractThis study aims to develop new molecular structures as potential therapeutic agents against COVID-19, utilizing bothin silicoandin vitrostudies. Potential targets of cepharanthine (CEP) against COVID-19 to reveal its underlying mechanism of action were evaluated usingin silicoscreening experiments. A library of new molecules was docked into the receptor binding domain of the SARS-CoV-2 spike glycoprotein complex with its receptor, human ACE2, to identify promising compounds. Receptor-oriented docking was performed using the most likely macromolecular targets, aimed at inhibiting key viral replication pathways and reducing inflammatory processes in damaged tissues. The hit molecules showed potential inhibition of Mpro and PLpro proteases of SARS-CoV-2, which are involved in viral replication. They also showed a potential inhibitory effect on Janus kinase (Jak3), which mediates intracellular signaling responsible for inflammatory processes.Thein vitrostudy examined the effects of the selected hit molecules on the generation of superoxide anions and the release of elastase in activated neutrophils, which are factors that exacerbate tissue inflammation and worsen the clinical manifestations of COVID-19. It was demonstrated that 2-((5-((4-isopropylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(3-methoxyphenyl)acetamide (Hit15) inhibited virus infection by 43.0% at 10μM using pseudovirus assay and suppressed fMLF/CB-induced superoxide anion generation and elastase release in human neutrophils with IC50values 1.43 and 1.28μM, respectively.Hit15showed promising activity against coronavirus that can be further developed into a therapeutic agent.Graphical Abstract
Aldolase B and Angiotensinogen are associated with weekly chronic multisite spinal pain in men
Authors: Ruotsalainen Hilla , Drouard Gabin , Pedersen Andreas , Ståhl Minna , Kanninen Katja M. , Kaprio Jaakko 
Published: November 2024

AbstractSpinal pain problems increase with age, but already 21% of Finnish young adults suffer from a musculoskeletal disorder. Chronic widespread pain (CWP) significantly increases one’s disability level and up to 50% of people experiencing chronic pain report symptoms of depression. Diagnosing pain is challenging, as it is a subjective feeling and current clinical pain descriptors are not accurate enough to determine pain perception. In this study, variation in the human plasma proteome was investigated with untargeted Mass Spectrometry in young adult twins with weekly chronic multisite spinal pain (n=94), twins with weekly chronic local neck pain (n=99), and healthy twin individuals (n=236). The association of depression with pain and sex-specific proteins in the studied associations was also investigated. The main data analysis approach included multiple regressions which were done with Generalized Linear Mixed Models (GLMM). Of the 411 studied proteins, Aldolase B and Angiotensinogen were negatively associated with weekly chronic concomitant neck and back pain in men. These proteins are known to relate to muscle atrophy and might thus contribute to the development of musculoskeletal pain. In addition, individuals with weekly chronic concomitant neck and back pain had more symptoms of depression than individuals with weekly chronic local neck pain. Further research is needed to identify the key proteins for clinical settings and upcoming pain proteomics research should include both women and men to examine sex differences.
Quality of life of Type II Diabetic patients
Authors: Ghimire Sulochana , Neupane Gita , Sah Chanda , Ghimire Mahesh Raj , Soti Binita 
Published: November 2024

AbstractObjectiveDiabetes mellitus poses significant challenges to individuals’ well-being, affecting various aspects of their lives beyond the physical symptoms of the disease. Understanding the multidimensional aspects of QoL among diabetic patients is crucial for providing holistic healthcare interventions and improving overall health outcomes. The study aims to evaluate the quality of life of Type II Diabetes Mellitus patients.Research Design and MethodsDescriptive cross-sectional study was conducted among 334 diagnosed cases of Type 2 Diabetes Mellitus for more than or equal to 6 months attending the outpatient department of UCMS-TH. Non-probability purposive sampling technique was used to select samples for the study. The WHOQOL-BREF questionnaire was used to measure QoL. Data were analyzed with descriptive statistics (frequency, percentage, mean, standard deviation) and inferential statistics (t-tests or one way ANOVA) to explore associations between QoL domains and sociodemographic characteristics.ResultsMore than half (56.6%) of the respondents were between the age group of 41-60 years with mean age of 58.42. Highest mean score ± SD was found in social domain (60.77 ± 13.83) followed by environmental domain (56.05 ± 10.38) and psychological domain (55.67 ±8.44) with least mean domain score in physical domain (49.99 ± 14.53). The results show that diabetic patients, particularly women and those with comorbid conditions, report lower quality of life in all domains. Additionally, no significant association was found between having a family history of diabetes and quality of life. There was high positive correlation between physical and environmental domain of quality of life (r = 0.70, p < 0.001).ConclusionComprehensive management strategies focusing on all dimensions of health is necessary to improve the quality of life of patients with Diabetes Mellitus.
The Use of Carotid Web Angioarchitecture in Stratification of Stroke Risk
Authors: Negash Bruck , Wiggan Daniel D. , Grin Eric A. , Sangwon Karl L. , Chung Charlotte , Gutstadt Eleanor , Sharashidze Vera , Raz Eytan , Shapiro Maksim , Ishida Koto , Torres Jose L , Zhang Cen , Nakatsuka Michelle A , Rostanski Sara K , Rethana Melissa J. , Kvernland Alexandra , Sanger Matthew , Lillemoe Kaitlyn , Allen Alexander , Kelly Sean , Baranoski Jacob , Rutledge Caleb , Riina Howard A. , Nelson Peter Kim , Nossek Erez 
Published: November 2024

AbstractObjectiveTo validate the carotid web (CW) risk stratification assessment described in our previous work with a larger cohort of patients with incidentally found asymptomatic CWs.MethodsA retrospective analysis of our electronic medical record database identified all patients with a diagnosis of CW from 2017-2024 at our institution. We included symptomatic patients and those with asymptomatic carotid webs, meaning patients with incidentally found webs and no history of stroke or transient ischemic attack (TIA). Patient charts were reviewed for demographics, imaging, comorbidities, hospital course, and incidence of stroke after diagnosis of an asymptomatic carotid web. All angles were measured as described in our previous work on a sagittal reconstruction of CTA imaging of the neck in which the common carotid artery (CCA), external carotid artery (ECA), and ICA could be well visualized, along with the CW itself. A standard logistic regression was performed to evaluate the association between the number of high-risk angles and stroke risk.Results26 asymptomatic and nine symptomatic patients were identified. Patients were categorized as having 0, 1, or 2+ high-risk angle values. Patients with more high-risk angles had a markedly higher risk of stroke (OR = 5.91, 95% CI: [4.25, 8.24]). The probability of stroke increased with the number of high-risk angles: patients with 2+ high-risk angles (83.4%) had the highest stroke probability compared to those with 0 (2.8%) or 1 (27.7%) high-risk angles. In the asymptomatic cohort, mean angles all fell below the high-risk threshold values. In the symptomatic cohort, mean angles were above the high-risk threshold values, whereas the mean CPT (53.6°) angle fell below the cut-off value for designation as a high-risk angle.ConclusionsGiven the successful stratification of CWs into high and low-risk groups in this study, the utilization of geometric CW parameters may play a crucial role in improvement of patient selection for intervention in patients with an incidental diagnosis of CW.
TRPV4 channel contributes to aortic root stiffening and atherosclerotic lesion development
Authors: Rahaman Suneha G. , Dutta Bidisha , Rahaman Shaik O. 
Published: November 2024

AbstractCardiovascular disease is the number one cause of death in the developed world and atherosclerosis, a chronic arterial disease, is the most dominant underlying pathology. Epidemiologic and experimental studies suggest that arterial stiffness is a risk factor for atherosclerosis. However, there has been surprisingly limited development in mechanistic understanding of the generation of arterial stiffness and little progress in understanding the mechanisms by which matrix stiffening drives the development of atherosclerosis.Various proinflammatory and fibrotic activities of macrophages and fibroblasts, such as migration, inflammatory gene expression, and myofibroblast activation, are influenced by matrix stiffness. This influence suggests that aorta stiffening may regulate atherosclerosis via a cellular stiffness sensor. Our research indicates that mechanosensitive transient receptor potential vanilloid 4 (TRPV4) channels control inflammation and fibrosis in other organs and regulate macrophage and fibroblast activation, implicating TRPV4 as a potential stiffness sensor in atherosclerosis. This suggests a cycle where inflammation, fibrosis, and tissue stiffening reinforce each other, with macrophages playing a key role. Here, we identify a cellular stiffness sensor linking matrix stiffness and atherosclerosis using human aortic tissues, a murine atherosclerosis model, and atomic force microscopy (AFM) analysis. This novel finding suggests that targeting TRPV4 could be a selective strategy to prevent or suppress atherogenesis.