bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic performance of the replaceable steel links with different short length ratios
Authors: Xiong Liquan , Guo Zhengchao , Cai Jun , Jiang Kaiyu , Li Linyan 
Published: December 2024

AbstractCompared with the traditional frame structures, the novel composite frame with replaceable steel links can realize the rapid recovery of building occupancy after seismic actions to provide the capacity of reducing structural damage and ensure the reuse of a structure. In this system, plastic deformation and damage mainly concentrated in the steel links serving as the structural fuses and other structural members still remained elastic or minor plastic, and then the damaged steel links can be easy for replace. In order to study the seismic performance of the replaceable steel links, a total of four test specimens with different short length ratios were designed. A low-cycle reversed loading test was carried out in terms of failure characteristic, hysteretic response and shear strength. The results indicated that all tested specimens presented a stable and full hysteretic response while the steel links especially exhibited a large inelastic deformation capacity and fully developed shear strength as the structural fuses. Besides, failure modes of steel links included two types of shear failure and bending-shear failure, followed by two types of damage features, including web-to-stiffener weld tear, web buckling, flange-to-end plate weld tear and flange buckling, respectively. Finally, nonlinear finite element models (FEMs) of test specimens were implemented by the Abaqus software. The numerical results were in good agreement with the experimental results in terms of load-deformation curves, initial stiffness, the development of Von Mises stress and cumulative plastic equivalent strain (PEEQ) indexes to facilitate design practice.
Gating-spring stiffness increases outer-hair-cell bundle stiffness, damping, and receptor current
Authors: Zhu Zenghao , Reid Wisam , Ó Maoiléidigh Dáibhid 
Published: December 2024

AbstractIn our ears, outer-hair-cell bundles (OHBs) convert sound-induced forces into receptor currents that drive cochlear amplification, the process responsible for the micropascal-scale threshold and million-fold dynamic range of hearing. OHBs rely on gating springs to open mechanoelectrical-transduction (MET) ion channels, through which the receptor current flows. OHBs have larger gating-spring stiffnesses than other types of hair bundles, but we have a poor understanding of how gating-spring stiffness contributes to OHB mechanics and receptor-current regulation. Using experimentally-constrained mathematical models of the OHB, we show that the increased gating-spring stiffness in an OHB increases its stiffness and damping. The OHB’s 3D morphology reduces the contribution of gating-spring stiffness to OHB stiffness, reduces the contribution of MET-channel gating to OHB stiffness and damping, but causes additional OHB damping that rises with gating-spring stiffness. Gating-spring stiffness increases the OHB’s receptor current but decreases its displacement-current dynamic range. Strikingly, the OHB’s 3D morphology causes its force-current dynamic range to decrease with gating-spring stiffness. Our results suggest a trade-off between threshold and dynamic range regulated by OHB gating-spring stiffness.
Intratumoral heterogeneity drives acquired therapy resistance in a patient with metastatic prostate cancer
Authors: Rhinehart Dena P. , Lai Jiaying , Sanin David E. , Vakkala Varsha , Mendes Adrianna , Bailey Christopher , Antonarakis Emmanuel S. , Paller Channing J. , Wu Xiaojun , Lotan Tamara L. , Karchin Rachel , Sena Laura A. 
Published: December 2024

AbstractMetastatic prostate cancer (PCa) is not curable due to its ability to acquire therapy resistance. Theoretically, acquired therapy resistance can be driven by changes to previously sensitive cancer cells or their environment and/or by outgrowth of a subpopulation of cancer cells with primary resistance. Direct demonstration of the latter mechanism in patients with PCa is lacking. Here we present a case report as proof-of-principle that outgrowth of a subpopulation of cancer cells lacking the genomic target and present prior to therapy initiation can drive acquired resistance to targeted therapy and threaten survival in patients with PCa.
Identification of responsible sequences which mutations cause maternal H19-ICR hypermethylation with Beckwith–Wiedemann syndrome-like overgrowth
Authors: Hara Satoshi , Matsuhisa Fumikazu , Kitajima Shuji , Yatsuki Hitomi , Kubiura-Ichimaru Musashi , Higashimoto Ken , Soejima Hidenobu 
Published: December 2024

AbstractBeckwith-Wiedemann syndrome (BWS) is caused by a gain of methylation (GOM) at the imprinting control region within the Igf2-H19 domain on the maternal allele (H19-ICR GOM). Mutations in the binding sites of several transcription factors are involved in H19-ICR GOM and BWS. However, the responsible sequence(s) for H19-ICR GOM with BWS-like overgrowth has not been identified in mice. Here, we report that a mutation in the SOX-OCT binding site (SOBS) causes partial H19-ICR GOM, which does not extend beyond CTCF binding site 3 (CTS3). Moreover, simultaneously mutating both SOBS and CTS3 causes complete GOM of the entire H19-ICR, leading to the misexpression of the imprinted genes, and frequent BWS-like overgrowth. In addition, CTS3 is critical for CTCF/cohesin-mediated chromatin conformation. These results indicate that SOBS and CTS3 are the sequences in which mutations cause H19-ICR GOM leading to BWS-like overgrowth and are essential for maintaining the unmethylated state of maternal H19-ICR.
Mechanisms of axoneme and centriole elimination in Naegleria gruberi
Authors: Woglar Alexander , Busso Coralie , Garcia-Rodriguez Gabriela , Douma Friso , Croisier Marie , Knott Graham , Gönczy Pierre 
Published: December 2024

Abstract
The early branching eukaryote Naegleria gruberi can transform transiently from an amoeboid life form lacking centrioles and flagella to a flagellate life form where these elements are present, followed by reversion to the amoeboid state. The mechanisms imparting elimination of axonemes and centrioles during this reversion process are not known. Here, we uncover that flagella primarily fold onto the cell surface and fuse within milliseconds with the plasma membrane. Once internalized, axonemes are severed by Spastin into similarly-sized fragments that are then enclosed by membranes, before their contents are eliminated through the lysosomal pathway. Moreover, we discovered that centrioles undergo progressive K63 autophagy-linked poly-ubiquitination and K48 proteasome-promoting poly-ubiquitination, and that such ubiquitination occurs next to centriolar microtubules. Most centrioles are eliminated in either lysosomes or the cytoplasm in a lysosomal- and proteasome-dependent manner. Strikingly, we uncover in addition that centrioles can be shed in the extracellular milieu and taken up by other cells. Collectively, these findings reveal fundamental mechanisms governing the elimination of essential cellular constituents in Naegleria that may operate broadly in eukaryotic systems.
Coordination of cytochrome bc1 complex assembly at MICOS
Authors: Zerbes Ralf M , Colina-Tenorio Lilia , Bohnert Maria , von der Malsburg Karina , Peikert Christian D , Mehnert Carola S , Perschil Inge , Klar Rhena F U , de Boer Rinse , Kram Anita , van der Klei Ida , Oeljeklaus Silke , Warscheid Bettina , Rampelt Heike , van der Laan Martin 
Published: December 2024

Abstract
The boundary and cristae domains of the mitochondrial inner membrane are connected by crista junctions. Most cristae membrane proteins are nuclear-encoded and inserted by the mitochondrial protein import machinery into the inner boundary membrane. Thus, they must overcome the diffusion barrier imposed by crista junctions to reach their final location. Here, we show that respiratory chain complexes and assembly intermediates are physically connected to the mitochondrial contact site and cristae organizing system (MICOS) that is essential for the formation and stability of crista junctions. We identify the inner membrane protein Mar26 (Fmp10) as a determinant in the biogenesis of the cytochrome bc
1 complex (complex III). Mar26 couples a Rieske Fe/S protein-containing assembly intermediate to MICOS. Our data indicate that Mar26 maintains an assembly-competent Rip1 pool at crista junctions where complex III maturation likely occurs. MICOS facilitates efficient Rip1 assembly by recruiting complex III assembly intermediates to crista junctions. We propose that MICOS, via interaction with assembly factors such as Mar26, contributes to the spatial and temporal coordination of respiratory chain biogenesis.
Integrated modelling and simulation method of hybrid systems based on X language
Authors: Xie Kunyu , Zhang Lin , Wang Xiaohan , Wang Kunyu , Li Yingjie 
Published: December 2024

AbstractModel‐based systems engineering is now leading the way in supporting the design of complex products or systems. The integration of modelling and simulation of continuous‐discrete hybrid systems is the key of model‐based systems engineering. But the existing languages, formalisms and tools cannot support the unified modelling and simulation of hybrid systems and therefore reduces the efficiency of complex system development. To address this issue, this paper develops a design method of complex hybrid systems, which integrates modelling and simulation of the continuous‐discrete hybrid behaviour. Specifically, the authors provided a modelling method of hybrid systems based on the X language, a simulation method based on XDEVS, and a compilation algorithm to transform the hybrid model constructed with X language into XDEVS simulation files. In this way, the X language hybrid model can be automatically translated into XDEVS simulation files by a compiler. The simulation files can then be simulated by the XDEVS simulation engine. The obtained simulation results will be used to verify whether the design scheme meets the design requirements of the hybrid system. Finally, the correctness and feasibility of the proposed method are verified using a car‐driving model.
Training improvement methods of ANN trajectory predictors in power systems
Authors: Kim Sangwon 
Published: December 2024

AbstractThis paper proposes training improvement methods of artificial neural networks (ANN) trajectory predictors. First, a dynamic power system time‐series trajectory is split into several different segments to simplify the original ANN training problem. Moreover, the time‐derivative of the trajectory is included to obtain an augmented loss function. Compared to previous studies which mainly focused on increasing the prediction accuracy, the aim of these novel techniques is to reduce the computational burden where the ANN output performance is still acceptable. The effectiveness of the developed methods is validated based on the WSCC three‐machine nine‐bus and IEEE 39‐bus system models. The mean absolute error (MAE) and trajectory prediction results are analysed, in which the numbers of neurons, hidden layers, and training epochs are constrained during the ANN training process. Rotor‐angle difference between generators and the system frequency are investigated as the dynamic trajectories of the power system models. The approaches are revealed to be effective when the ANN architecture and epochs are constrained. The MAE results can be reduced by up to 65% in the power system models depending on the ANN hyperparameters and training epochs. The ANN training results can better reflect the original trajectory as well.
Automated surgical skill assessment in endoscopic pituitary surgery using real‐time instrument tracking on a high‐fidelity bench‐top phantom
Authors: Das Adrito , Sidiqi Bilal , Mennillo Laurent , Mao Zhehua , Brudfors Mikael , Xochicale Miguel , Khan Danyal Z. , Newall Nicola , Hanrahan John G. , Clarkson Matthew J. , Stoyanov Danail , Marcus Hani J. , Bano Sophia 
Published: December 2024

AbstractImproved surgical skill is generally associated with improved patient outcomes, although assessment is subjective, labour intensive, and requires domain‐specific expertise. Automated data‐driven metrics can alleviate these difficulties, as demonstrated by existing machine learning instrument tracking models. However, these models are tested on limited datasets of laparoscopic surgery, with a focus on isolated tasks and robotic surgery. Here, a new public dataset is introduced: the nasal phase of simulated endoscopic pituitary surgery. Simulated surgery allows for a realistic yet repeatable environment, meaning the insights gained from automated assessment can be used by novice surgeons to hone their skills on the simulator before moving to real surgery. Pituitary Real‐time INstrument Tracking Network (PRINTNet) has been created as a baseline model for this automated assessment. Consisting of DeepLabV3 for classification and segmentation, StrongSORT for tracking, and the NVIDIA Holoscan for real‐time performance, PRINTNet achieved 71.9% multiple object tracking precision running at 22 frames per second. Using this tracking output, a multilayer perceptron achieved 87% accuracy in predicting surgical skill level (novice or expert), with the ‘ratio of total procedure time to instrument visible time’ correlated with higher surgical skill. The new publicly available dataset can be found at https://doi.org/10.5522/04/26511049.
Die Hemisektion unterer zweiter Milchmolaren bei Unterzahl der
zweiten Prämolaren – Geschichte, Anwendung und klinisches
Vorgehen
Authors: Langer Lisa Josefine , Finke Christian , Becker Kathrin 
Published: December 2024

ZusammenfassungDer Umgang mit Nicht-Anlagen bleibender Zähne ist eine anspruchsvolle Aufgabe im
Praxisalltag. Die weltweite Prävalenz der Nicht-Anlage eines oder mehrerer Zähne
variiert stark und liegt unter Ausschluss der 3. Molaren bei 0,15% – 16,18%
1
2.
Die zweiten Prämolaren im Unterkiefer sind hierbei die häufigsten nicht
angelegten Zähne 3
4
5
6
7
8. Die Prävalenz der Nicht-Anlage der unteren
zweiten Prämolaren beträgt je nach Studie und untersuchter Population zwischen
1,02% – 3,5% 9
10
11. Patientinnen sind in der
Regel häufiger betroffen als Patienten 9
11
12. Insofern es indiziert und erwünscht ist einen
kieferorthopädischen Lückenschluss in dieser Region anzustreben, sollte bei
Extraktion der Zähne 75 und 85 eine übermäßige Atrophie des Alveolarfortsatzes
verhindert werden, da diese einen Lückenschluss erschwert beziehungsweise
verlangsamt 13. Bereits sechs Monate nach
erfolgter Extraktion kann sich der Alveolarfortsatz bis zu 1,87 mm in der Breite
und zwischen 1,24–2,03 mm in der Höhe reduzieren 14
15.Die Hemisektion unterer Milchmolaren bei Nicht-Anlage der unteren zweiten
Prämolaren schafft es durch den Verbleib eines Zahnanteils, die Knochenatrophie
zu vermindern und stellt außerdem eine nebenwirkungsarme und effektive
Alternative einer kieferorthopädischen Verankerungsmöglichkeit dar.Ziel dieses Artikels ist es, auf die Geschichte der Hemisektion in der
Kieferorthopädie einzugehen, Anwendungsbereiche aufzuzeigen und Indikationen zu
erläutern.
Indirektes Kleben unter Anwendung von
CAD/CAM-Technologie
Authors: Sabbagh Hisham , Becker Kathrin , Jungbauer Rebecca 
Published: December 2024

ZusammenfassungDigitale Technologien haben zur Entwicklung neuer Ansätze in der indirekten
Bracketplatzierung geführt. Dabei kann die Bracketplatzierung virtuell in
Softwareprogrammen durchgeführt werden, wobei verschiedene Simulations- und
Individualisierungmöglichkeiten angewendet werden können. Anschließend ist eine
modellfreie Herstellung der Bracketübertragungsschienen mithilfe von 3D-Druck
Verfahren möglich.Dieser Artikel fasst den Hintergrund und aktuelle Literatur zum
CAD/CAM-Indirect-Bonding zusammen und stellt den Arbeitsprozess anhand eines
Fallbeispiels dar.
3D-Druck palatinal verankerter Apparaturen: eine
Übersicht
Authors: Mücke Katharina , Küffer Maximilian , Wilmes Benedict , Becker Kathrin 
Published: December 2024

ZusammenfassungDer 3D-Druck, oder auch additive Fertigung genannt, hat die Kieferorthopädie
erheblich verändert. Indem er die Herstellung präziser, individuell angepasster
Apparaturen ermöglicht, verbessert der 3D-Druck sowohl die Effizienz der
Behandlung als auch den Patientenkomfort. In den letzten Jahren haben sich
insbesondere der Einsatz von Computer-Aided Design (CAD)/Computer-Aided
Manufacturing (CAM)-Systemen und Metall-3D-Druckverfahren, wie das selektive
Laserschmelzen (SLM), durchgesetzt. In der Kieferorthopädie ermöglichen diese
Technologien, festsitzende Apparaturen (Brackets[1], Lingualretainer [2],
Hyrax-Expander[3], skelettal verankerte Apparaturen[4]), herausnehmbare
Apparaturen [5] und komplexe, individualisierte Apparaturen (multipurpose
Apparaturen) digital zu planen und direkt zu drucken, teilweise sogar bereits
ohne die Notwendigkeit physischer Modelle [6].
Pilotierung und Evaluation einer partizipativen, digitalen Akte für gerontopsychiatrische Patienten und ihre Care-Partner
Authors: Meier-Diedrich Eva , Dahling Volker , Esch Tobias , Hägglund Maria , Heinze Martin , Hochwarter Stefan , Wagener Marie , Schwarz Julian 
Published: December 2024

ZUSAMMENFASSUNG
Hintergrund Ältere Patienten sind in ihrer Gesundheitsversorgung häufig auf Angehörige, sog. „Care-Partner” (CP), angewiesen. Diese erhalten oft nur erschwert Zugang zu relevanten Gesundheitsdaten der Patienten und können deshalb nur begrenzt unterstützen. CP einen digitalen Zugang zur elektronischen Akte und zur klinischen Behandlungsdokumentation der Patienten zu geben, stellt einen innovativen Beitrag zur Lösung dieses Problems dar. Es werden die Barrieren und Chancen des Lösungsansatzes untersucht.
Methoden Ältere Patienten (n = 8) und deren CP (n = 8) erhalten online Zugang zur ärztlichen Behandlungsdokumentation via eines webbasierten Patientenportals. Es werden qualitative Interviews (n = 16) zu den Erfahrungen mit dem Zugang für CP geführt.
Ergebnisse Sowohl Patienten als auch CP erleben bei der Nutzung Barrieren und Chancen. Der Kontakt zu den Behandlern verbessert und vereinfacht sich. Patienten stehen in Arztgesprächen weniger unter Druck, da sie via Online-Zugang die Arztkontakte nach- und vorbereiten können. CP fühlen sich besser in die Gesundheitsversorgung einbezogen und entlastet. Einige Patienten gelang es aufgrund von technischen Schwierigkeiten und/oder fehlender digitaler Gesundheitskompetenz nicht, den Online-Zugang selbstständig zu nutzen, sodass Verantwortung an die CP abgegeben wurde.
Diskussion CP nehmen eine zentrale Rolle in der digitalen Gesundheitsversorgung von Patienten ein. Damit auch ältere Patienten als gleichberechtigte Partner an ihrem digitalen Gesundheitsmanagement teilhaben, ist es erforderlich, spezifische Angebote zu entwickeln, die sie in der Entwicklung digitaler Kompetenzen unterstützen.
Frequency agile photonic integrated external cavity laser
Authors: Lihachev Grigory , Bancora Andrea , Snigirev Viacheslav , Tian Hao , Riemensberger Johann , Shadymov Vladimir , Siddharth Anat , Attanasio Alaina , Wang Rui Ning , Visani Diego A. , Voloshin Andrey , Bhave Sunil A. , Kippenberg Tobias J. 
Published: December 2024

Recent advances in the development of ultra-low loss silicon nitride integrated photonic circuits have heralded a new generation of integrated lasers capable of reaching fiber laser coherence. However, these devices are presently based on self-injection locking of distributed feedback laser diodes, increasing both the cost and requiring tuning of laser setpoints for their operation. In contrast, turn-key legacy laser systems use reflective semiconductor optical amplifiers (RSOAs). While this scheme has been utilized for integrated photonics-based lasers, so far, no cost-effective RSOA-based integrated lasers exist that are low noise and simultaneously feature fast, mode-hop-free, and linear frequency tuning as required for frequency modulated continuous wave (FMCW) LiDAR or for laser locking in frequency metrology. Here we overcome this challenge and demonstrate a RSOA-based, frequency agile integrated laser, that can be tuned with high speed, with high linearity at low power. This is achieved using monolithic integration of piezoelectrical actuators on ultra-low loss silicon nitride photonic integrated circuits in a Vernier filter-based laser scheme. The laser operates at 1550 nm, features a 6 mW output power and a 400 Hz intrinsic laser linewidth, and allows ultrafast wavelength switching within 7 ns rise time and 75 nW power consumption. In addition, we demonstrate the suitability for FMCW LiDAR by showing laser frequency tuning over 1.5 GHz at 100 kHz triangular chirp rate with a nonlinearity of 0.25% after linearization and use the source for measuring a target scene 10 m away with a 8.5 cm distance resolution.
Inferring fusion nuclear burnwidths with low gain photomultiplier impulse response functions
Authors: Meaney K. D. , Jeet J. , Carrera J. , Mariscal E. , Schlossberg D. , Moore A. , Eckart M. , Milnes J. , Hink P. , Hillyard P. , Holdener D. , Herrmann H. , Geppert-Kleinrath H. , Kim Y. 
Published: December 2024

When an inertial confinement fusion implosion is compressed, it maintains thermonuclear density and temperatures for a very short time scale, about 100 ps. The Gamma Reaction History diagnostic measures the time evolution of the fusion burn, but its temporal resolution is limited by the use of a photomultiplier tube (PMT) to amplify the photon signal. Multichannel plate-based PMTs have a fast (∼120 ps) full-width at half-max impulse response function (IRF), but the time scale is similar to the incoming physics signal. An analysis routine is used to remove the effect of the PMT IRF and infer the incident fusion burnwidth. With the National Ignition Facility achieving ignition and creating much brighter signals, the PMTs are run at gains three orders of magnitude lower than nominal operation. Calibration at these settings shows the PMT IRFs get ∼15% wider. Taking the gain-dependent IRF can affect the inferred nuclear burnwidths by up to ∼15%.
Development of a diagnostic system for atomic processes in the whole divertor region of HL-3
Authors: Ma Huicong , Cai Laizhong , Gao Jinming , Fan Dongmei , He Zongyuhui , Du Hailong , Wang Dezhen 
Published: December 2024

The atomic processes are important for understanding the mechanisms of divertor detachment physics. The developed diagnostic system for atomic processes aims to present the atomic process distributions of ionization and recombination in the whole divertor region of HL-3, which is equipped with the multi-channel visible imaging optics, two SCMOS cameras having identical parameters, and bandpass filters. This configuration enables high spatiotemporal resolution measurements of Balmer lines across the entire divertor region. The maximum frequency of the cameras is 400 fps (512 pixel × 512 pixel), and the field of view covers the entire 1100 × 650 cm2 area of the divertor with the spatial resolution of 1 × 1 cm2. The intensity ratio of experimental measurements of Balmer lines can be used to assess the leading region of ionization, transition from ionization to recombination, and recombination from the Atomic Data and Analysis Structure database. The preliminary results show that ionization is primarily distributed near the last closed flux surface (LCFS), while the transition from ionization to recombination and recombination predominate within a limited region distant from the LCFS. Through the corresponding S/XB, the numbers of ionization and recombination per unit time within the divertor region are obtained. With the evolution of time, the electron density gradually increases, and the ionization region and ionization rate gradually increase. This holds immense significance in advancing our comprehension of the detachment mechanism, facilitating real-time control of divertor detachment and steady-state control technology of heat load in the future.