bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diamond Technique: A Triple Treatment for Neck and Décolletage Rejuvenation
Authors: dos Santos Teodoro Matheus , da Fonseca Armada Barros João Henrique , da Cunha Ana Lúcia Gonzaga 
Published: December 2024

ABSTRACTBackgroundIn the pursuit of integral beauty and a harmonious overall appearance, individuals are increasingly seeking cosmetic treatments for both facial and extrafacial regions. Among these areas, the neck and décolleté have become focal points for care due to their visibility and susceptibility to postsurgical scarring and dyschromia compared with the face. Environmental stressors and sun exposure contribute to aging signs in these areas, prompting a demand for effective, minimally invasive procedures with reduced downtime and minimal risks. Biostimulators, hyaluronic acid, laser therapy, microfocused ultrasound and neurotoxins have become key players in addressing these concerns.AimsThis manuscript introduces the Diamond technique, which uses a diamond‐shaped acetate device to perform a minimally invasive protocol combining calcium hydroxyapatite, hyaluronic acid, and incobotulinumtoxinA for neck and décolleté rejuvenation.Patients/MethodsThe technique involves two steps: solution preparation and device‐guided injections. The diamond‐shaped device was developed to guide the injections, enhancing precision and reproducibility and facilitating medical training. The device's strategic markings aid in solution application, ensuring a multidimensional approach to rejuvenation. Four female patients, aged between 55 and 63 years were used to demonstrate the technique, with two categorized as grade II and two as grade III according to the Merz scale of neck laxity at rest.ResultsThe four examples demonstrate improvements in skin laxity, wrinkles, and overall skin quality. Two participants reported “good results,” and two reported results “beyond expectations.” The Diamond technique's potential lies in its ability to provide predictable outcomes, individualized treatments, and patient satisfaction.ConclusionWhile the authors assert the technique's safety and efficacy, the need for controlled studies is crucial. Rigorous, long‐term studies are warranted to validate its effectiveness and safety compared with the existing approaches.
Exploration of Effective Substance Use Relapse Prevention Programmes for the Youth: An Integrative Literature Review
Authors: Gaolaolwe Wada , Moagi Miriam Mmamphamo , Kovane Gaotswake Patience , Sehularo Leepile 
Published: December 2024

ABSTRACTIntroductionYouth substance use has been associated with recurrent episodes of substance misuse. A large body of research has shown that relapsing into substance use is still a significant obstacle that prevents people who use substances and want to stop from recovering and abstaining. The objective of this evaluation was to locate, compile and summarise the results of all pertinent research on youth substance use relapse prevention programmes.MethodAn integrative literature review (ILR) was conducted, guided by Whittemore and Knafl (Journal of Advanced Nursing, 2005, 52, 546), following a step‐by‐step guide for conducting an ILR. The PRISMA guidelines were used in the selection process.ResultsTwenty‐three papers met the eligibility criteria, and three were added from grey literature. Three themes identified in the studies included in the review: Continuing care, technology‐mediated recovery management interventions and relapse prevention through developmentally engaging activities.DiscussionThe review identified that a successful substance use relapse prevention programme for the youth requires continued care following discharge from hospital treatment. The care encompasses posttreatment check‐ups, assessments and linkages to treatment in which a suspected/potential relapse is referred back to treatment to prevent its severity or occurrence.
Macro‐ and micronutrient effects on phytoplankton in Green Bay, Lake Michigan, and the western basin of Lake Erie
Authors: Stoll Jordyn T. , Larson James H. , Bailey Sean W. , Blackwood Christopher B. , Costello David M. 
Published: December 2024

AbstractEfforts to reduce the frequency, extent, and toxicity of harmful algal blooms (HABs) require knowledge about drivers of algal growth, toxin production, and shifts in phytoplankton community composition to cyanobacterial dominance. Although labile nitrogen (N) and phosphorus (P) fuel primary production, micronutrients also play roles as the enzymatic engines that facilitate rapid and efficient growth and toxin production. Macro‐ and micronutrient availability can shape community composition and function by selecting for particular taxa. To address how phytoplankton in two Great Lakes subbasins respond to macro‐ and micronutrients, we conducted bottle incubation enrichment experiments using water collected from two blooming and two nonblooming sites in Lakes Erie and Michigan during late summer (August). Three of the four sites exhibited multi‐nutrient limitation of growth. Both blooming sites responded strongest to enrichment. Both nonblooming sites responded the strongest to enrichment, and three of the four sites responded in some way to a mix of micronutrients (Fe, Mn, Mo, Ni, and Zn). Microcystis aeruginosa relative abundance increased most with N enrichment, while P enrichment increased the abundance of diatoms and chlorophytes. At the Fox River, N‐enriched communities grew 10%–20% more than non‐N enriched communities (measured as chlorophyll a), and N‐enriched communities had, on average, over twice as much microcystin (non‐N communities average MC = 2.45 μg · L−1, +N communities MC = 5.35 μg · L−1). These overarching trends support the idea that control of HABs may not be effective with a P‐only approach.
Rising Female‐Headed Households: Shifts in Living Arrangements or Heightened Gender Symmetry?
Authors: Trias‐Prats Rita , Esteve Albert 
Published: December 2024

AbstractCensuses and surveys predominantly report men as heads of households or reference persons despite women carrying out most domestic and care work. Recent evidence, however, suggests that an increasing number of households are headed by women. Using data from the newly released CORESIDENCE database, which includes over 770 data points from 156 countries worldwide spanning from 1960 to 2021, this study presents the first global map of female headship, traces its recent evolution, and compares female‐headed households with male‐headed ones based on selected household characteristics. The results confirm the widespread increase in female headship in virtually all world regions. Nevertheless, significant cross‐national differences persist, and changes are not uniform across all regions. Spatial and temporal variations in female headship can be attributed, in part, to structural shifts in living arrangements, specifically the decreased presence of adult men in households. Female headship, however, is rising beyond the structural transformation of households. Women are increasingly likely to head households even in the presence of adult men, particularly their male partners. This might be indicative of normative changes towards gender symmetry. We discuss the potential factors behind these transformations and consider their implications for further research and gender equality.
A single nucleotide polymorphism affects protein translation and leads to post‐anthesis color change variation in closely related Lotus species
Authors: Gao Ruifang , Li Yueqing , Shan Xiaotong , Wang Yanan , Yang Siqi , Ma Saiyu , Xia Ziyi , Zheng Huibo , Wei Chao , Tong Linna , Qin Jianchun , Gao Xiang , Cronk Quentin 
Published: December 2024

SUMMARYFlower color change, a common phenomenon that is important in pollination ecology, has intrigued scientists for decades. While previous flower color studies have mainly focused on color diversity among different plant species, our focus is on unraveling the mechanism of post‐anthesis color change (PACC) and the molecular basis for its presence and absence, respectively, in two closely related species of Lotus, Lotus filicaulis and Lotus japonicus MG20. Metabolomic analysis reveals anthocyanins as the key metabolites responsible for the observed PACC. Differential expression of anthocyanin biosynthetic and transport genes causes the variation in PACC between the two Lotus species. Crucially, the significant upregulation of a functionally characterized MYB regulator, LfPAP1, is linked to the accumulation of anthocyanins and visible color alterations in L. filicaulis flowers. Notably, we uncover a nucleotide polymorphism in the initiation codon of LjPAP1. Although this mutation does not affect transcription, we show that it has a major effect in attenuating protein translation, reducing its capacity to activate anthocyanin biosynthesis, and leading to a failure of PACC in L. japonicus MG20. Our study sheds light on mechanisms of PACC phenomenon and highlights the potential for mutations in initiation sequences to generate phenotypic differences between species in evolution.
Effect of the added plasma rinseback on residual cell types in plateletpheresis leukoreduction systems
Authors: Kelly Kathleen , Finlon Jeff , Fulciniti Stefan , Lee Deborah , Jones Micaela , Marschner Susanne 
Published: December 2024

AbstractBackgroundPlatelets collected by the Trima Accel apheresis device (Terumo BCT) are automatically leukoreduced through a leukoreduction system (LRS) where WBCs are trapped in a conical‐shaped LRS chamber. The content has been used as a valuable source of mononuclear cells for research purposes. In frequent, long‐term platelet apheresis donors, lymphopenia has been associated with the use of LRS chambers, and implementation of plasma rinseback at the end of the procedure has been shown to mitigate the depletion of lymphocytes. In this report, the cellular content of the LRS chamber and remaining disposable was characterized with and without plasma rinseback.Study Design and MethodsTrima disposable sets were obtained from apheresis platelet collections in 100% plasma or 35% plasma/65% PAS with or without plasma rinseback at the end of the collections. Cellular content was drained from the LRS chamber and the disposable and was characterized using a hematology analyzer and flow cytometer to establish total cell counts and proportions of RBC, platelet, and WBC subpopulations.ResultsLRS chambers contained approximately 109 WBCs, with the majority being lymphocytes and monocytes. The addition of plasma rinseback significantly decreased the number of WBCs remaining in the disposable, thereby increasing the number of WBCs returned to the donor. However, rinseback did not impact the WBC content of the LRS chamber itself.ConclusionsBlood Centers using the Trima Accel instrument may reduce lymphopenia in regular platelet donors by implementing plasma rinseback, while ensuring the cellular content of the LRS chamber intended for research purposes remains unaffected.
Do Pre‐Treatment Biopsy Characteristics Predict Early Tumour Progression in Feline Diffuse Large B Cell Nasal Lymphoma Treated With Radiotherapy?
Authors: Poirier Valerie J. , Meier Valeria , Turek Michelle , Christensen Neil , Bowal Jacqueline , Ponzini Matthew D. , Keller Stefan M. 
Published: December 2024

ABSTRACTThe standard of care treatment for localised feline nasal lymphoma (FeNL) is radiation therapy (RT). Early local or systemic failure occurs in 17%–45% of cats treated with RT with or without chemotherapy. The aim of this study was to determine if pre‐treatment biopsy characteristics could predict early tumour progression in FeNL. Inclusion criteria consisted of histologically confirmed FeNL, available paraffin blocks of diagnostic quality, localised to the sinonasal cavity on staging pre‐RT, treated with IMRT/IGRT (10 × 4.2 Gy) without chemotherapy and at least 1 year follow‐up. All pre‐RT biopsies were reviewed and evaluated with CD3, CD20, CD79a, pan‐CK and Ki‐67 immunohistochemistry and the mitotic activity index was determined. The primary endpoint was progression‐free survival (PFS) at 1 year and hazard‐ratios (HR) with confidence interval (CI) were calculated. Twenty‐eight cats fit the inclusion criteria, and all had diffuse large B‐cell lymphoma. Seventeen cats (61%) were progression free at 1 year. Of the 11 cats that progressed in the first year, two had local progression, two had both local and systemic progression and seven had systemic progression. The mitotic index (HR: 1.03, CI 0.9–1.19, p = 0.645), Ki‐67 (HR: 1.00, CI 0.98–1.02, p = 0.845) and > 30% of tumour‐infiltrating T cells (HR: 0.38, CI 0.09–1.56, p = 0.175) were not significantly associated with PFS. In this uniformly RT treated population of FeNL, none of the evaluated pre‐RT histologic parameters could predict early treatment failure.
50% body weight loading reduces stature increases and lumbar disc expansion from 4 h hyper‐buoyancy floatation versus 15 min sitting upright
Authors: Marcos‐Lorenzo David , Lysandrou Christina , Sudres Laura , Gil‐Martinez Alfonso , Swanenburg Jaap , Clark James Edward , Green David Andrew 
Published: December 2024

AbstractMicrogravity is associated with stature increases, back pain and post‐flight intervertebral disc (IVD) herniation. This study aims to determine whether 30 s seated 50% body weight (BW) axial loading is comparable to 15 min sitting upright in 1 g upon changes in stature, anterior lumbar IVD height (via ultrasound), passive vertebral stiffness (VS), and back pain induced by 4 h hyper‐buoyancy floatation (HBF) unloading. Sixteen (seven male) healthy volunteers had stature, lumbar IVD height (L2–S1), passive VS (C1–L5) and back pain assessed before and following 4 h HBF, and immediately after participants performed a 30 s seated squat with 50% of their BW or 15 min sitting upright. Four hours of HBF unloading induced significant increments in stature (+1.6 ± 0.5 cm; P < 0.001), IVD height (L2–L3: P = 0.002; L3–L4: P < 0.001; L4–L5: P = 0.013; L5–S1: P < 0.001) and back pain (2.90 ± 1.26; P < 0.001) with no differences between 1 and 1.5 BW. Stature, IVD height increments and back pain were similarly attenuated in both reloading groups. Passive VS was unchanged by 4 h HBF or reloading. HBF‐induced back pain positively correlated with stature (P = 0.01) and lumbar IVD height changes (L2–L3: P = 0.03; L3–L4: P = 0.01; L5–S1: P = 0.02). Four hours of HBF increased stature, lumbar IVD height and induced moderate back pain that were similarly (albeit not entirely) ameliorated by both 15 min upright sitting and 30 s of 50% BW axial loading, with no changes in passive VS observed. IVD geometric changes appear key to space adaptation back pain and stature increments that can be rapidly modulated by brief periods of axial loading.
Do Large Language Models Produce Diverse Design Concepts? A Comparative Study with Human-Crowdsourced Solutions
Authors: Ma Kevin , Grandi Daniele , McComb Christopher , Goucher-Lambert Kosa 
Published: December 2024

Abstract
Access to large amounts of diverse design solutions can support designers during the early stage of the design process. In this article, we explored the efficacy of large language models (LLMs) in producing diverse design solutions, investigating the level of impact that parameter tuning and various prompt engineering techniques can have on the diversity of LLM-generated design solutions. Specifically, we used an LLM (GPT-4) to generate a total of 4000 design solutions across five distinct design topics, eight combinations of parameters, and eight different types of prompt engineering techniques, leading to 50 LLM-generated solutions for each combination of method and design topic. Those LLM-generated design solutions were compared against 100 human-crowdsourced solutions in each design topic using the same set of diversity metrics. Results indicated that, across the five design topics tested, human-generated solutions consistently have greater diversity scores. Using a post hoc logistic regression analysis, we also found that there is a meaningful semantic divide between humans and LLM-generated solutions in some design topics, but not in others. Taken together, these results contribute to the understanding of LLMs’ capabilities and limitations in generating a large volume of diverse design solutions and offer insights for future research that leverages LLMs to generate diverse design solutions for a broad range of design tasks (e.g., inspirational stimuli).
Acute Responses to Different Velocity-Loss Thresholds During Squat Training With and Without Blood-Flow Restriction
Authors: Sánchez-Valdepeñas Juan , Cornejo-Daza Pedro J. , Páez-Maldonado José , Rodiles-Guerrero Luis , Cano-Castillo Clara , Piqueras-Sanchiz Francisco , González-Badillo Juan José , Sáez de Villarreal Eduardo , Pareja-Blanco Fernando 
Published: December 2024

Purpose: To compare the acute effects on mechanical, metabolic, neuromuscular, and muscle contractile responses to different velocity-loss (VL) thresholds (20% and 40%) under distinct blood-flow conditions (free [FF] vs restricted [BFR]) in full squat (SQ). Methods: Twenty strength-trained men performed 4 SQ protocols with 60% 1-repetition maximum that differed in the VL within the set and in the blood-flow condition (FF20: FF with 20% VL; FF40: FF with 40% VL; BFR20: BFR with 20% VL; and BFR40: BFR with 40% VL). The level of BFR was 50% of the arterial occlusion pressure. Before and after the SQ protocols, the following tests were performed: (1) tensiomyography, (2) blood lactate, (3) countermovement jump, (4) maximal voluntary isometric SQ contraction, and (5) performance with the load that elicited a 1 m·s−1 at baseline measurements in SQ. Results: No “BFR × VL” interactions were observed. BFR protocols resulted in fewer repetitions and lower increases in lactate concentration than FF protocols. The 40% VL protocols completed more repetitions but resulted in lower mechanical performance and electromyography median frequency during the exercise than the 20% VL protocols. At postexercise, the 40% VL protocols also experienced greater blood lactate concentrations, higher alterations in tensiomyography-derived variables, and accentuated impairments in SQ and countermovement-jump performances. The 20% VL protocols showed an increased electromyography median frequency at postexercise maximal voluntary isometric contraction. Conclusions: Despite BFR-accelerated fatigue development during exercise, a given VL magnitude induced similar impairments in the distinct performance indicators assessed, regardless of the blood-flow condition.
Surgical pathology and sustainable development: international landscape and prospects
Authors: Vergara Rémi , Théate Ivan , Boor Peter , Gordon Ilyssa O , West Jonathan , Abdelmoula Selma , Tilmant Cyprien , Wiseman Pinto Roque Gabriel , Gaillot-Durand Lucie , Scott Sheri , Trecourt Alexis , Rullier Anne 
Published: December 2024

The healthcare sector significantly contributes to global greenhouse gas emissions, with surgical pathology (SP) playing a notable role. This review explores the ecological transformation of SP, offering a global overview of existing challenges and sustainable initiatives worldwide.While some countries, such as the UK and France, have developed national strategies to reduce the carbon footprint of healthcare, including SP, many regions remain at an early stage of implementing green practices. Several studies have assessed the carbon footprint of SP, focusing on key aspects such as laboratory operations, pathology procedures and functional units, highlighting materials and transportation as major contributors to emissions. The integration of digital pathology and artificial intelligence (AI) presents opportunities to enhance efficiency and address medical deserts but also poses challenges due to the associated energy consumption.Local initiatives such as the ‘Transformation Ecologique en Anatomie et Cytologie Pathologiques’ (Ecological transformation in SP) or TEAP collective in France, Belgium’s ‘Green Team’ and sustainable practices in Tunisia and New Zealand demonstrate the global effort to reduce the environmental impact of SP. Key strategies discussed include ecodesign of care, circular economy practices, green AI and partnerships with industry. However, achieving meaningful reductions in SP’s environmental impact requires international cooperation and support from national health policies. This review emphasises the importance of collaborative efforts to implement sustainable solutions without compromising the quality and safety of healthcare services.
$$\gamma $$-Ray spectroscopy above the 9$$^+$$ isomeric state in the N = Z nucleus $$^{66}$$As
Authors: Joukainen Henna , Ruotsalainen Panu , Sarén Jan , Srivastava Praveen C. , Patel Deepak , Julin Rauno , Auranen Kalle , Ge Zhuang , Grahn Tuomas , Greenlees Paul , Illana Andres , Jutila Henri , Leino Matti , Louko Jussi , Luoma Minna , Ojala Joonas , Pakarinen Janne , Rahkila Panu , Sandzelius Mikael , Tann Holly , Uusitalo Juha , Zimba George L. 
Published: December 2024

Abstract
Excited states above the

$$9^+$$

9
+

isomer in the odd-odd N = Z nucleus

$$^{66}$$

66

As were studied by employing the

$$^{40}$$

40

Ca(

$$^{28}$$

28

Si, pn) fusion-evaporation reaction at the Accelerator Laboratory of the University of Jyväskylä, Finland. A key method in this study was the use of conversion electrons emitted in the de-excitation of the isomeric state in

$$^{66}$$

66

As as a tag for prompt

$$\gamma $$

γ

rays. Several new states have been added to the

$$^{66}$$

66

As level scheme, which was extended up to a tentative spin of 23

$$\hbar $$

ħ

. The previously reported even-spin yrast band has been reassigned to have odd spin values. The odd-spin states above the

$$9^+$$

9
+

isomer are compared with shell-model calculations using the jj44b and JUN45 interactions. Additionally, the recoil-

$$\beta $$

β

tagging efficiency of the recently developed scintillator detector named Tuike has been determined experimentally for the first time.