bluuebunny/crossref_metadata_2025_split huggingface dataset:
Questionnaire survey on association between preeclampsia and incontinentia pigmenti
Authors: Sun Xiaoyan , Huang Yu , Si Dayong , Gao Shichao , Wang Peichang 
Published: May 2019

AbstractAimIn this study, a questionnaire survey was conducted to find the relationship between preeclampsia (PE) and incontinentia pigmenti (IP).MethodsUsing a questionnaire survey of 147 women whose children were diagnosed with IP, this study first investigated their clinical manifestations and complications during pregnancy. The manifestations included high blood pressure, proteinuria and edema after 20 weeks of gestation. Women with and without IP were separated into two groups, then analyzed accordingly.ResultsThere were 45 mothers with IP in the case group and 102 mothers without IP in the control group. IP mothers who were pregnant with an IP fetus were at higher risk for hypertension, proteinuria, and edema during pregnancy as compared with non‐IP mothers that carried an IP fetus. Out of these 147 mothers, 8 mothers with IP and 6 mothers without IP presented with new‐onset hypertension during pregnancy (P = 0.024)，7 mothers with IP and 4 mothers without IP presented with new‐onset proteinuria during pregnancy (P = 0.013)，and 21 IP mothers and 27 non‐IP mothers presented with edema during pregnancy (P = 0.016). Although no statistical difference was observed, mothers in the case group were more likely to develop the above three symptoms concurrently (6.7% vs 2.0%; P = 0.168), and were more likely to be diagnosed with PE (8.9% vs 3.9%; P = 0.249).ConclusionOur study revealed that the simultaneous occurrence of IP in the mother and fetus increased the likelihood of clinical manifestations associated with PE during pregnancy.
Pulse granuloma presenting as a complex pelvic cyst
Authors: Maeda Yuto , Uematsu Kazuhiko , Matsubayashi Aya , Yoshioka Shinya 
Published: May 2019

AbstractPulse granuloma, a benign granulomatous lesion, develops due to foreign body reactions to food particles. This rare entity occurs occasionally in the abdominal cavity. However, it has never been reported as a pelvic mass or a recurrent case. A 37‐year‐old woman with a medical history of pelvic granulomatous lesions treated in Thailand, was admitted for abdominal pain. Imaging study revealed a pelvic complex cyst and disseminated nodules. Ovarian cancer or tuberculous peritonitis was suspected. The appearance at laparotomy was an inflammatory mass encased in adhesions; therefore, only biopsy was performed. The pathology diagnosis was pulse granuloma. The pathology report from Thailand was obtained only after her discharge, suggesting that the previous granulomatous lesion contained vegetable matter. This report demonstrates that pulse granuloma can present as a pelvic mass and may relapse. For complex cystic lesions with solid components in the pelvis, pulse granuloma should be considered as a differential diagnosis.
Effects of a blend of thyme, peppermint and eucalyptus essential oils on growth performance, serum lipid and hepatic enzyme indices, immune response and ileal morphology and microflora in broilers
Authors: Hesabi Nameghi Alireza , Edalatian Ommolbanin , Bakhshalinejad Reza 
Published: May 2019

AbstractThis study was conducted to evaluate the effect of a blend of essential oils (EOB) derived from thyme (Thymus vulgaris), peppermint (Mentha piperita) and eucalyptus (Eucalyptus globules) as a natural growth promoter. Five dosages (0 (CON), 50, 100, 150 and 200 ppm) of EOB were added daily to the drinking water to determine its effect on growth performance, carcass quality, blood biochemistry, immune response and ileal morphology in Ross 308 broiler chicks. A total of 500, 10‐day‐old male Ross 308 broilers were allocated into five treatments with four replicates each. Inclusion of EOB at 150 ppm improved (p < 0.05) body weight gain, feed conversion ratio and production index by 11.73, 10.81 and 24.13% compared to CON respectively. The inclusion of EOB at 100, 150 and 200 ppm increased (p < 0.05) carcass yield and thigh muscle compared to CON. Serum concentration of hepatic enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) was decreased while the ileal villus height and ratio of villus height to crypt depth were improved (p < 0.05) in response to inclusion of 150 and 200 ppm of EOB compared to CON. The ileal Escherichia coli count was lower and Lactobacillus count was higher in EOB‐200 and EOB‐150, respectively, compared to CON at 21 and 42 days of age (p < 0.05). Antibody titre of Newcastle, bronchitis and infectious bursal disease was linearly increased (p < 0.05) by increasing supplemental level of EOB at day 4 post‐inoculation. Our results suggested that supplementation of EOB at the 150 ppm into drinking water during day 11–42 could improve growth performance, humoral immunity and ileal morphology and microflora in broilers, and thus, EOB has merit to be used as an alternative to antibiotic growth promoters.
Male and female cats have different regional body compositions and energy requirements for weight loss and weight maintenance
Authors: Vasconcellos Ricardo Souza , Gonçalves Karina Nogueira Venturelli , Borges Naida Cristina , de Paula Francisco José Albuquerque , Canola Júlio Carlos , de Oliveira Sampaio Gomes Márcia , Miltenburg Tânia Zóia , Carciofi Aulus Cavalieri 
Published: May 2019

AbstractBody composition and energy requirements are different between males and females in several species, and both interfere with weight loss. The aim of this study was to compare the total and regional body composition and energy requirements in obese male (n = 8) and female (n = 8) cats, during weight loss and weight maintenance over 17 subsequent weeks after regimen. The total and regional (thoracic and pelvic limbs, and trunk) body composition was assessed by dual‐energy X‐ray absorptiometry (DXA). Females exhibited a higher fat mass (FM) than males (p < 0.05), and the trunk was the site with greater fat accumulation regardless of gender. A 23.0 ± 2.8% reduction in body weight was followed by a 50.3 ± 9.4% and a 37.0 ± 8.9% reduction in fat in the trunk region in males and females respectively. Lean mass (LM) mobilization was also increased in the trunk (p < 0.05), and the loss of LM was associated with a reduction in bone mass. The energy intake to achieve the same rate of weight loss was 12.9 ± 3.4% higher in males (p < 0.05). The cats exhibited a gradual increase in energy requirements to maintain their body weight after weight loss (p < 0.05). It was concluded that obese cats mainly accumulate fat in the trunk. The reduction in lean mass after the regimen also occurred in the trunk, with no modifications in the skeletal muscle mass of the limbs. Neutered male cats have higher energy requirements than neutered females, and gender should be considered during obesity management in cats.
Efficacy and safety of a two‐drug direct‐acting antiviral agent regimen ruzasvir 180 mg and uprifosbuvir 450 mg for 12 weeks in adults with chronic hepatitis C virus genotype 1, 2, 3, 4, 5 or 6
Authors: Lawitz Eric , Gane Edward , Feld Jordan J. , Buti Maria , Foster Graham R. , Rabinovitz Mordechai , Burnevich Eduard , Katchman Helena , Tomasiewicz Krzysztof , Lahser Fred , Jackson Beth , Shaughnessy Melissa , Klopfer Stephanie , Yeh Wendy W. , Robertson Michael N. , Hanna George J. , Barr Eliav , Platt Heather L. ,   the C‐BREEZE‐2 Study Investigators
Published: May 2019

AbstractRuzasvir (MK‐8408, an NS5A inhibitor) and uprifosbuvir (MK‐3682, a nonstructural protein 5B nucleotide inhibitor) are highly potent direct‐acting antiviral agents for the treatment of hepatitis C virus (HCV) infection. A phase III clinical trial evaluating the two‐drug combination of ruzasvir 60 mg plus  uprifosbuvir 450 mg suggested suboptimal efficacy in certain HCV genotypes (C‐BREEZE 1; NCT02759315). The aim of the present study was to evaluate the efficacy and safety of ruzasvir in combination with uprifosbuvir administered at a higher dose than that assessed in the earlier study (C‐BREEZE 2: NCT02956629/Merck protocol PN041). Treatment‐naïve or interferon (with or without ribavirin)‐experienced participants with or without compensated cirrhosis were enrolled. All participants received ruzasvir 180 mg plus uprifosbuvir 450 mg once daily for 12 weeks. The primary objectives were the proportion of participants with HCV RNA <15 lU/mL at 12 weeks after the end of study therapy (SVR12), and safety and tolerability of the study drug. Overall, 282 participants were enrolled. SVR12 (n/N) was 91.3% (42/46) in participants infected with HCV genotype (GT) 1a; GT1b, 96.7% (29/30); GT2, 91.5% (43/47); GT3, 73.8% (45/61); GT4, 98.2% (55/56); GT5, 100.0% (18/18); and GT6, 90.9% (20/22). Adverse events (AEs) were reported by 61.3% of participants; drug‐related AEs were reported by 33.3%. The most frequent (≥5% of participants) drug‐related AEs in all participants were fatigue (7.8%) and headache (7.4%). In conclusion, the two‐drug combination of ruzasvir 180 mg plus uprifosbuvir 450 mg for 12 weeks was highly effective and well tolerated in participants infected with HCV GT1, GT2, GT4, GT5 and GT6, with a lower efficacy in GT3‐infected persons.
Haematobia irritans parasitism of F1 yak × beef cattle (Bos grunniens × Bos taurus) hybrids
Authors: Calkins C. M. , Scasta J. D. , Smith T. , Stayton M. M. , Lake S. L. 
Published: May 2019

AbstractThe horn fly Haematobia irritans (Diptera: Muscidae) is a blood obligate ectoparasite of bovids that causes annual losses to the U.S. beef cattle industry of over US$1.75 billion. Climate warming, the anthropogenic dispersion of bovids and the cross‐breeding of beef cattle with other bovid species may facilitate novel horn fly–host interactions. In particular, hybridizing yaks [Bos grunniens (Artiodactyla: Bovidae)] with beef cows (Bos taurus) for heterosis and carcass improvements may increase the exposure of yak × beef hybrids to horn flies. The present paper reports on the collection of digital images of commingled beef heifers (n = 12) and F1 yak × beef hybrid bovids (heifers, n = 7; steers, n = 5) near Laramie, Wyoming (∼ 2200 m a.s.l.) in 2018. The total numbers of horn flies on beef heifers and F1 yak × beef heifers [mean ± standard error (SE): 88 ± 13 and 70 ± 17, respectively] did not differ significantly; however, F1 yak × beef steers had greater total horn fly abundance (mean ± SE: 159 ± 39) than female bovids. The present report of this experiment is the first such report in the literature and suggests that F1 yak × beef bovids are as susceptible as cattle to horn fly parasitism. Therefore, similar monitoring and treatment practices should be adopted by veterinarians, entomologists and producers.
Comparative pathogenicity of opportunistic black yeasts in Aureobasidium
Authors: Wang Meizhu , Danesi Patrizia , James Timothy Y. , Al‐Hatmi Abdullah M. S. , Najafzadeh Mohammad Javad , Dolatabadi Somayeh , Ming Chunyan , Liou Guey‐Yuh , Kang Yingqian , de Hoog Sybren 
Published: May 2019

SummaryAureobasidium pullulans and A. melanogenum are black‐yeast‐like surface colonisers and are commonly encountered as contaminants in the hospital. The species are able to produce melanin which play a role in protection against environmental stress and irradiation. Aureobasidium melanogenum shows higher frequency in opportunistic infections compared to A. pullulans. Comparative pathogenicity of opportunistic black yeasts between Aureobasidium pullulans and A. melanogenum to explain the observed differences in frequency in infection. Degrees of melanisation and thermotolerance were measured, and virulence of strains from different sources was examined in Galleria mellonela and murine infection models. Aureobasidium melanogenum responds with increased melanisation to temperature stress and generally survives at 37°C, A. pullulans on average scored less on these parameters. In the murine model, differences between species were not significant, but the melanised A. melanogenum group showed the highest virulence. This result was not reproducible in Galleria mellonella larvae at 25°C. The A. melanogenum black group showed higher pathogenicity in murine model, indicating that the combination of melanisation and thermotolerance rather than species affiliation is instrumental. Galleria larvae did not survive very well at 37°C, and hence, this model is judged insufficient to detect the small virulence differences observed in Aureobasidium.
The safety and efficacy of electroanatomical mapping (EAM)‐guided device implantation
Authors: Patel Hardik , Hiner Evan , Naqvi Amir , Wrobel Jessica , Machado Christian 
Published: May 2019

AbstractBackgroundThe conventional method of device implantation requires fluoroscopic guidance. With the guidance of three‐dimensional (3‐D) navigation systems, devices can be implanted with minimal use of fluoroscopy. To date, this technique has been reported in several case reports in young, pregnant patients. However, this technique has not been widely utilized by electrophysiologists, despite offering several benefits, including reduced radiation exposure for the patient and the operator.MethodsIn this study, we evaluated 18 patients who successfully underwent device implantation with limited use of fluoroscopy under the guidance of the EnSite Precision 3‐D mapping navigation system (Abbott, St. Paul, MN, USA). In most of the patients, the total fluoroscopy time was 1 s, accounted by a single postprocedural frame to insure appropriate lead placement.ResultsA total of 19 leads were implanted in 18 patients (14 male, four female) using the electroanatomical mapping (EAM)‐guided technique. A total of 19 leads were implanted in 15 patients (10 male, five female) using the conventional method. The average length of stay was 1.20 days in the EAM group compared to 1.47 days in the conventional group (P = .10). Majority of the devices implanted in both groups were single‐chamber implantable cardiac defibrillators (VVI ICD, Abbott) implanted for cardiomyopathy with left ventricular ejection fraction persistently below 35%, including 88% (16/18) in the EAM group compared to 73% (11/15) in the conventional group. No periprocedural or immediate postprocedure complications were reported in either group. Device parameters, including impedance, capture time, and capture voltage, showed no significant difference in either group. Total radiation time and radiation dose were markedly lower in the EAM‐guided implantation group.ConclusionsIn patients who meet appropriate criteria for device implantation, the use of EAM system offers a safe, practical, efficacious alternative method to device implantation, with significant reduction in radiation time and dose.
Ultrasound‐guided combined pectoral nerve block and axillary venipuncture for the implantation of cardiac implantable electronic devices
Authors: Bozyel Serdar , Yalnız Ahmet , Aksu Tolga , Guler Tumer Erdem , Genez Samet 
Published: May 2019

AbstractBackgroundCombined ultrasound (US)‐guided pectoral nerves (PECS) block and axillary vein (AV) puncture for cardiac implantable electronic devices can be effective to achieve optimal perioperative pain management and prevent access‐related complications.MethodsA total of 36 patients who underwent combined US‐guided PECS block and AV puncture were included. All routinely recorded parameters, including clinical and demographic characteristics, periprocedural medical administrations, the time taken for both PECS block and AV puncture, procedure time, postprocedural pain score, and procedure‐related complications, were collected and analyzed.ResultsIn total, 54 leads were placed in 36 patients. The combined US‐guided PECS block and AV puncture was performed successfully in 35 (97.2%) patients without the need for fluoroscopy or venography. AV access for each lead was achieved in a single attempt in 80.6% of cases. The time for both PECS block and AV puncture was 223.6 ± 52.1 s, including the time to apply incision site anesthesia. Additional sedatives and/or local anesthetics were required in two patients during procedure. Visual analog scale average of the patients in the 1st, 6th, and 24th h was 3.7 ± 1.14. 1.61 ± 1.29, and 0.08 ± 0.28, respectively. After the procedure, four patients (three of them woman) needed analgesics. There were no venous access‐related complications.ConclusionsThis new combined technique maintains both surgical and postoperative analgesia and prevents vascular access‐related complications without significant increase on procedure time.
Risk of severe maternal morbidity in relation to prepregnancy body mass index: Roles of maternal co‐morbidities and caesarean birth
Authors: Leonard Stephanie A. , Carmichael Suzan L. , Main Elliott K. , Lyell Deirdre J. , Abrams Barbara 
Published: May 2019

AbstractBackgroundAn association between prepregnancy body mass index (BMI) and severe maternal morbidity (SMM) has been reported, but evidence has been mixed and potential explanations have not been examined.ObjectiveTo evaluate the association between prepregnancy BMI and SMM in a large, diverse birth cohort and assess potential mediation by obesity‐related co‐morbidities and caesarean birth.MethodsThis cohort study used linked birth certificate and hospitalisation discharge records from Californian births during 2007‐2012. We assessed associations between prepregnancy BMI and SMM, and used inverse probability weighting for multiple mediators to estimate relative and absolute natural direct and indirect effects accounting for mediation by co‐morbidities (hypertensive conditions, diabetes, asthma) and caesarean birth.ResultsAmong 2 650 182 births, the prevalence of SMM was 1.42%. Adjusted risk ratios for the total association between prepregnancy BMI category and SMM were 1.12 (95% confidence interval [CI] 1.07, 1.18) for underweight, 1.02 (95% CI 0.99, 1.04) for overweight, 1.04 (95% CI 1.00, 1.07) for obesity class 1, 1.14 (95% CI 1.09, 1.20) for obesity class 2, and 1.28 (95% CI 1.22, 1.36) for obesity class 3 compared to women with normal weight. After accounting for mediation by co‐morbidity and caesarean birth, the risk ratios were 1.19 (95% CI 1.14, 1.26) for underweight, 0.91 (95% CI 0.89, 0.94) for overweight, 0.86 (95% CI 0.84, 0.89) for obesity class 1, 0.88 (95% CI 0.84, 0.92) for obesity class 2, and 0.89 (95% CI 0.83, 0.95) for obesity class 3.ConclusionsCo‐morbidities and caesarean birth explained an association between high prepregnancy BMI and SMM. These findings suggest that promotion of healthy prepregnancy weight, along with management of co‐morbidities and support of vaginal birth in pregnant women with high BMI, could reduce the risk of SMM. However, these mediators did not reduce the elevated risk of SMM observed in women with low BMI.
Distorted Input Ratios in Vertical Relationships*
Authors: Peitz Martin , Shin Dongsoo 
Published: May 2019

AbstractA project leader sources an input from a supporter and combines it with an input produced in‐house. The leader has private information about the project's cost environment. We show that if the leader can commit to the in‐house input level, the input ratio is distorted upward when the in‐house input is not too costly – the in‐house input is produced in excess and thus partly wasted. By contrast, without the leader's commitment to the in‐house input level, the input ratio is distorted downward when the in‐house input is sufficiently costly – the outsourced input is produced in excess and thus partly wasted.
Bioimaging of multiple elements by high‐resolution LA‐ICP‐MS reveals altered distribution of mineral elements in the nodes of rice mutants
Authors: Yamaji Naoki , Ma Jian Feng 
Published: May 2019

SummaryInter‐vascular transfer in rice (Oryza sativa) nodes is required for delivering mineral elements to developing tissues, which is mediated by various transporters in the nodes. However, the effect of these transporters on distribution of mineral elements in the nodes at a cellular level is still unknown. Here, we established a protocol for bioimaging of multiple elements at a cellular level in rice node by laser ablation‐inductively coupled plasma‐mass spectrometry (LA‐ICP‐MS), and compared the mineral distribution profile between wild‐type (WT) rice and mutants. Both relative comparison of mineral distribution normalized by endogenous 13C and quantitative analysis using spiked standards combined with soft ablation gave valid results. Overall, macro‐nutrients such as K and Mg were accumulated more in the phloem region, while micro‐nutrients such as Fe and Zn were highly accumulated at the inter‐vascular tissues of the node. In mutants of nodal Zn transporter OsHMA2, Zn localization pattern in the node tissues did not differ from that of WT; however, Zn accumulation in the inter‐vascular tissues was lower in uppermost node I but higher in the third upper node III compared with the WT. In contrast, Si deposition in the mutants of three nodal Si transporters Lsi2, Lsi3 and Lsi6 showed different patterns, which are consistent with the localization of these transporters. This improved LA‐ICP‐MS analysis combined with functional characterization of transporters will provide further insight into mineral element distribution mechanisms in rice and other plant species.
Exome sequences and multi‐environment field trials elucidate the genetic basis of adaptation in barley
Authors: Bustos‐Korts Daniela , Dawson Ian K. , Russell Joanne , Tondelli Alessandro , Guerra Davide , Ferrandi Chiara , Strozzi Francesco , Nicolazzi Ezequiel L. , Molnar‐Lang Marta , Ozkan Hakan , Megyeri Maria , Miko Peter , Çakır Esra , Yakışır Enes , Trabanco Noemi , Delbono Stefano , Kyriakidis Stylianos , Booth Allan , Cammarano Davide , Mascher Martin , Werner Peter , Cattivelli Luigi , Rossini Laura , Stein Nils , Kilian Benjamin , Waugh Robbie , van Eeuwijk Fred A. 
Published: May 2019

SummaryBroadening the genetic base of crops is crucial for developing varieties to respond to global agricultural challenges such as climate change. Here, we analysed a diverse panel of 371 domesticated lines of the model crop barley to explore the genetics of crop adaptation. We first collected exome sequence data and phenotypes of key life history traits from contrasting multi‐environment common garden trials. Then we applied refined statistical methods, including some based on exomic haplotype states, for genotype‐by‐environment (G×E) modelling. Sub‐populations defined from exomic profiles were coincident with barley's biology, geography and history, and explained a high proportion of trial phenotypic variance. Clear G×E interactions indicated adaptation profiles that varied for landraces and cultivars. Exploration of circadian clock‐related genes, associated with the environmentally adaptive days to heading trait (crucial for the crop's spread from the Fertile Crescent), illustrated complexities in G×E effect directions, and the importance of latitudinally based genic context in the expression of large‐effect alleles. Our analysis supports a gene‐level scientific understanding of crop adaption and leads to practical opportunities for crop improvement, allowing the prioritisation of genomic regions and particular sets of lines for breeding efforts seeking to cope with climate change and other stresses.