bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reproductive Health Education Study Materials for Junior High School Students
Authors: Rochmayani Dewi Sari , Zulaekha Chusnul 
Published: August 2019

Background: Some indicators of reproductive health education in schools have not reached the expected level. A preliminary study on junior high school students shows that 90% of students have poor reproductive health knowledge. This situation is an indicator of the weak reproductive health education in junior high schools.
Methods: The design of this study is research and development. The study continued with field tests on 30 junior high school teachers in the Mijen sub-district of Semarang City.
Results: The study succeeded in formulating 5 materials and 18 study materials on reproductive health education for junior high school students. The material includes: 1) Male and female reproductive organs, 2) Personal protection from sexual abuse, 3) Problems related to reproductive health behavior, 4) Sexually transmitted diseases and HIV-AIDS, 5) Environmental care for reproductive health. The mapping results show that 50% of teachers have never learned the materials : the structure and function of reproductive organs, the types of sexually transmitted diseases, and the health effects of sexually transmitted diseases. The level of teacher knowledge about reproductive health education was 26.7% including the excellent category, 33.3% good and 36.7% sufficient.
Conclusion: Materials health education for junior high school students need to be implemented through various forms of intra and extracurricular learning in junior high school.
Indústria 4.0: O Papel das Federações Empresariais
Authors: Klippel Rodrigo Zillig , Pitassi Claudio 
Published: August 2019

A adoção das tecnologias digitais que fizeram emergir a 4ª Revolução Industrial tornou-se crítica no ambiente de negócios da economia pós-industrial, trazendo para economias emergentes pressões ainda maiores no processo de globalização de suas empresas. O objetivo principal deste artigo foi entender como, na percepção dos empresários, a estratégia do Sistema FIRJAN pode colaborar para o desenvolvimento de políticas de estímulo à inovação e à inserção das empresas fluminenses na Indústria 4.0. O estudo adota uma abordagem qualitativa com finalidade exploratória, as evidências coletadas foram tratadas por um processo de codificação auxiliado pelo software ATLAS.ti. Os resultados obtidos indicaram que embora a rede de institutos de inovação contribuísse para a inovação localizada, ficou evidente a falta de políticas orientadas para inovação que promovam a real transformação da indústria fluminense. As narrativas obtidas indicam que grande parte dos empresários considera as tecnologias digitais ou virtuais um luxo dispensável. Esta resistência fortalece a percepção de que a indústria 4.0 é considerada uma realidade muito distante. De modo a superar uma visão míope e autocentrada de segredo industrial, a FIRJAN, deve criar um senso de urgência nos empresários e estimular, ainda que indiretamente, a troca de conhecimentos tecnológicos entre as empresas do estado.
From Somatic Variants Toward Precision Oncology: An Investigation of Reporting Practice for Next-Generation Sequencing-Based Circulating Tumor DNA Analysis
Authors: Peng Rongxue , Zhang Rui , Horan Martin P. , Zhou Li , Chai Sze Yee , Pillay Nalishia , Tay Kwang Hong , Badrick Tony , Li Jinming 
Published: August 2019

Abstract

Background
With the accelerated development of next-generation sequencing (NGS), identified variants, and targeted therapies, clinicians who confront the complicated and multifarious genetic information may not effectively incorporate NGS-based circulating tumor DNA (ctDNA) analysis into routine patient care. Consequently, standardized ctDNA testing reports are of vital importance. In an effort to guarantee high-quality reporting performance, we conducted an investigation of the current detection and reporting practices for NGS-based ctDNA analysis.

Materials and Methods
A set of simulated ctDNA samples with known variants at known allelic frequencies and a corresponding case scenario were distributed to 66 genetic testing laboratories for ctDNA analysis. Written reports were collected to evaluate the detection accuracy, reporting integrity, and information sufficiency using 21 predefined criteria.

Results
Current reporting practices for NGS-based ctDNA analysis were found to be far from satisfactory, especially regarding testing interpretation and methodological details. Only 42.4% of laboratories reported the results in complete concordance with the expected results. Moreover, 74.2% of reports only listed aberrations with direct and well-known treatment consequences for the tumor type in question. Genetic aberrations for which experimental agents and/or drug access programs are available may thus be overlooked. Furthermore, methodological details for the interpretation of results were missing from the majority of reports (87.9%).

Conclusion
This proof-of-principle study suggests that the capacity for accurate identification of variants, rational interpretation of genotypes, comprehensive recommendation of potential medications, and detailed description of methodologies need to be further improved before ctDNA analysis can be formally implemented in the clinic.
Ruh Sağlığında Mobil Uygulamalar: Etkinliğe Yönelik Sistematik Bir Gözden Geçirme
Authors: DURDU AKGÜN Başak , AKTAÇ Ayça , YORULMAZ Orçun 
Published: August 2019

Son yıllarda fiziksel ve ruhsal sağlığa yönelik geliştirilen akıllı telefon uygulamalarının sayısı hızla artmaktadır. Kullanımı hızla yaygınlaşan uygulamalar ruhsal rahatsızlıkların tedavisine alternatif ve destekleyici bir seçenek sunmaktadır. Bu derlemenin amacı, ruh sağlığı ile ilgili mobil uygulamaların etkinliğini randomize kontrollü çalışmalar (RKÇ) ile değerlendiren alanyazındaki çalışmaları sistematik olarak gözden geçirerek incelemektir. Çalışma kapsamında çeşitli veritabanlarında yayınlanan İngilizce makaleler belirlenen anahtar kelimeler kullanılarak taranmıştır. Yapılan tarama sonucunda dahil etme kriterlerine uygun 12 araştırma bu çalışmaya dahil edilmiştir; bu çalışmalar ise uygulamaların içeriği, örneklem, çalışma yöntemi ve bulgular açısından değerlendirilmiştir. Çalışmalardan elde edilen bulgular ışığında mobil uygulamaların genel olarak hedeflenen ruhsal bozukluk belirtilerini azaltmada etkili olduğu ve katılımcılar tarafından uygulamaların benimsendiği ve kullanımının kolay olduğunu rapor ettikleri görülmüştür.
PENGEMBANGAN BAHAN AJAR MATERI LOGIKA MATEMATIKA DENGAN PENDEKATAN PMRI UNTUK SISWA SMA KELAS X
Authors: Muslimahayati Muslimahayati 
Published: August 2019

Penelitian ini bertujuan menghasilkan bahan ajar materi logika matematika dengan pendekatan Pembelajaran Matematika Realistik Indonesia pada materi logika matematika untuk siswa SMA kelas X yang memenuhi kriteria valid dan praktis untuk digunakan dalam pembelajaran matematika. Metode yang digunakan dalam penelitian ini adalah metode Research and Development (R and D). Subjek dalam penelitian ini adalah 33 siswa kelas X.1 SMA Islam Al Falah Kota Jambi. Teknik pengumpulan data yang digunakan pada penelitian ini adalah lembar validasi, angket kepraktisan dan observasi. Bahan ajar matematika tersebut divalidasi oleh dua ahli materi dan ahli desain media pembelajaran dengan nilai baik. Kemudian dilakukan ujicoba produk terbatas, meminta tanggapan pada 5 orang siswa non subjek dan 2 orang guru matematika. Selanjutnya bahan ajar matematika tersebut diujicoba pemakaian pada siswa kelas X.1 di SMA Islam Al Falah Kota Jambi. Dari hasil analisis yang dilakukan terhadap tes akhir lembar penilaian kognitif (post test), diperoleh 72,72% nilai siswa mencapai kriteria ketuntasan minimum yaitu sebanyak 29 dari 33 siswa. Dan hasil observasi aktivitas siswa dalam proses pembelajaran rerata penilaian afektif siswa adalah 74,65 % dengan kategori ”baik” dan rerata hasil penilaian psikomotorik adalah 74, 81 % dengan kategori ”baik”. Hal ini berarti bahan ajar matematika yang dibuat telah sesuai dan efektif untuk pembelajaran matematika.
O PAPEL DAS COOPERATIVAS NO DESENVOLVIMENTO ECONÔMICO LOCAL: UM ESTUDO DE CASO NA COOPERATIVA COOPERNORTE.
Authors: Silva Josivaldo Alves da 
Published: August 2019

Este artigo tem como objetivo comparar as práticas cooperativistas da Cooperativa Agropecuária Tocantinense “Coopernorte” com os componentes teóricos da Nova Economia Institucional (NEI). A pesquisa foi realizada por meio de um estudo qualitativo das práticas de governança com base na percepção dos diretores da cooperativa, com relação às estratégias gerenciais adotadas para o controle dos custos das transações e o estabelecimento dos modos alternativos de organização e de produção, da influência dos arranjos institucionais externos no processamento e comercialização dos produtos, e do ambiente institucional onde ocorrem as relações contratuais da Coopernorte com seus fornecedores de matéria prima e compradores de produtos manufaturados. O método empregado foi investigação bibliográfica e documental, além do estudo de caso. A pesquisa é classificada como qualitativa e o instrumento utilizado foi um questionário com questões abertas, aplicado pessoalmente. Os principais resultados da investigação foram: A Coopernorte processa diariamente um volume aproximado de 8 mil litros de leite e conta atualmente em seus quadros com 445 associados e 22 colaboradores. Os custos de produção representam 20% do produto final. A comercialização representa um custo de 5% a 10%. O desperdício de matéria prima e produtos acabados chegam a 3%. A matéria prima é comprada do produtor associado com o prazo de pagamento de 30 dias.
Relasi Tasawuf dan Sains: Studi terhadap Pemikiran Osman Nuri Topbaş
Authors: Sulaiman Sulaiman 
Published: August 2019

<p class="06IsiAbstrak"><span lang="IN">A </span><span lang="EN-GB">Studi </span><span lang="IN">about </span><span lang="EN-GB">Osman Nuri Topbaş</span><span lang="IN"> idea. </span><span lang="EN-GB">The article will present the Osman Nuri Topbaş sufism ideas and his positive response to science, particularly </span><span lang="IN">in </span><span lang="EN-GB">the natural science. </span><span lang="IN">This study is using library research. The result of this study shows that Osman Nuri Topbas integrated the meaning of sufism in reading universe. For him first, </span><span lang="EN-GB"> that all God's creation </span><span lang="IN">from</span><span lang="EN-GB"> the micro level to the macro level is a remarkable manifestation of Divine</span><span lang="EN-GB">art. Secondly, he recalled the importance of capturing wisdoms in tangible physical world. And third, the consequences to catch wisdoms of the physical world </span><span lang="IN">are</span><span lang="EN-GB"> a necessity for us to develop a more sophisticated methodology than the bid </span><span lang="IN">from</span><span lang="EN-GB"> natural science</span><span lang="IN"> recently</span><span lang="EN-GB">. He realized that science has indeed marginalized religion, but it does not mean that Osman is anti-West science. </span><span lang="IN">The </span><span lang="EN-GB">important</span><span lang="IN"> is</span><span lang="EN-GB"> that science must be inspired by the values </span><span lang="EN-GB">of Sufism.</span></p>
Early Mobilization and Physiotherapy Vs. Late Mobilization and Home Exercises After ORIF of Distal Radial Fractures
Authors: Clementsen Ståle Ørstavik , Hammer Ola-Lars , Šaltytė Benth Jūratė , Jakobsen Rune Bruhn , Randsborg Per-Henrik 
Published: August 2019

Background:
Volar locking plates have permitted early mobilization, omitting the need for prolonged cast immobilization, after distal radial fractures (DRFs). However, the type of rehabilitation following plate fixation of DRFs remains an unresolved issue. The purpose of this study was to evaluate the effect of physiotherapy after volar plate fixation of DRFs. At a 2-year follow-up, we compared the results of immediate physiotherapy (early mobilization) with those of home exercises following 2 weeks in a dorsal plaster splint (late mobilization).

Methods:
Patients with an extra-articular DRF scheduled for open reduction and internal fixation (ORIF) with a volar locking plate were evaluated for eligibility for enrollment in the study. The patients were randomized into 2 groups: (1) early mobilization and physiotherapy and (1) late mobilization and home exercise. In the early mobilization group, the plaster splint was removed after 2 to 3 days. During the first 3 months, the patients met with the institution’s physiotherapist every other week. The late mobilization group wore the dorsal splint for 2 weeks and only met with our physiotherapist once, when the splint was removed. This group was provided with a home physiotherapy program and instructed to perform home exercises on their own.

Results:
One hundred and nineteen patients were included in the study. The 2 groups had similar demographics with respect to age, sex, and baseline values. Seven patients were lost to follow-up. No clinically relevant difference in scores on the shortened version of the Disabilities of the Arm, Shoulder and Hand (QuickDASH) questionnaire was found between the 2 groups at any of the follow-up evaluations. The largest difference in the QuickDASH score was found at 6 weeks, when the early mobilization group had a mean score of 30 compared with a mean of 37 in the late mobilization group (p = 0.05).

Conclusions:
Early mobilization and multiple physiotherapy visits did not improve wrist function compared with standard treatment of 2 weeks in a dorsal plaster splint, a single physiotherapy visit, and home exercises. Early mobilization following ORIF of an extra-articular DRF is safe.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
PLURALITAS DAN RELASI ANTAR AGAMA Analisis Struktural Relasi Kelompok Agama Antara Islam Dan Katolik Di Desa Caluk Kecamatan Slahung Kabupaten Ponorogo
Authors: Musyafa AB 
Published: August 2019

Penelitian ini diawali dari kegelisahan akademik penulis adalah bagaimana bisa agama yang pada asalnya mempunyai klaim kebenaran yang sifatnya primordial menjadi kebenaran yang sifatya universal. Berangkat dari kegelisahan akademik tersebut maka penelitian ini dilakukan dengan memfokuskan pada norma dan lembaga sosial yang mengikat mereka, dimana hal tersebut menjadikan harmonisasi kehidupan beragama. Dari fokus penelitian ini maka ada beberapa masalah yang dibahas; pertama, bentuk norma-norma yang ada yang menjadikan pemahaman agama masyarakat menjadi universal dan sekaligus juga primordial di desa Caluk tersebut. Kedua, bentuk lembaga sosial yang mewadahi norma-norma universalitas dan primordialitas agama masyarakat desa Caluk. Untuk membahas ini kami menggunakan pendekatan sosiologi dengan memanfaatkan teori fakta sosial Emile Durkheim. Tujuan dari masalah yang pertama adalah mendeskripsikan norma dan tujuan dari masalah yang kedua adalah mendeskripsikan lembaga sosial. Dari dua pembahasan tersebut disimpulkan bahwa norma yang mengubah sifat primordialitas agama ada tiga, yakni norma susila, kesopanan, dan agama. Sedangkan wadah norma tersebut adalah lembaga pemerintah dan agama.
Serum fibroblast growth factor 19 as a predictor for early stage of gastrointestinal-liver dysfunction in pediatric patients with sepsis
Authors: Tang Xiaomeng , Ren Yuqian , Wang Chunxia , Cui Yun , Xiong Xi , Miao Huijie , Sun Ting , Lu Ye , Shao Lujing , Zhang Yucai 
Published: August 2019

Abstract
Background: Fibroblast growth factor 19 (FGF19) secrets from intestinal epithelial cells and proved to be associated with functioning ileum in Crohn’s disease and alcoholic steatohepatitis. In the present study, we aimed to explore the potential value of FGF19 as a biomarker for assessment of gastrointestinal (GI) dysfunction in pediatric patients with sepsis.Methods: We performed a prospective study to enroll pediatric patients with sepsis admitted to the pediatric intensive care unit (PICU) at Shanghai Children’s Hospital from January 2018 to December 2018. Serum FGF19 levels at PICU admission were determined, and the clinical and laboratory parameters were collected.Results: Significantly decreased serum FGF19 levels were found in patients with sepsis-associated GI dysfunction. Lower serum FGF19 levels than 60 μg/mL on PICU admission is predictive for GI dysfunction. Correlation analyses revealed significant correlations of serum FGF19 with hemoglobin, and low FGF19 serum concentration less than 52 μg/mL on PICU admission is related to GI dysfunction-associated liver injury. Conclusion: Serum FGF19 is a novel predictor for GI dysfunction or GI-liver dysfunction in pediatric patients with sepsis.
Time To Recovery And Its Predictors Among Severe Community Acquired Pneumonia Patients Admitted To Pediatric Ward, Debre-markos Referral Hospital, North West Ethiopia, Retrospective Follow-up Study, 2019
Authors: Mitiku Belayneh Mengist 
Published: August 2019

Abstract
Background

- Globally, pneumonia is a major cause of morbidity and mortality among children which affects 151.8 million each year. It leads over 156 million episodes and 14.9 million hospitalizations per year. Besides this fact, the recovery time and predictors of children’s hospitalization related to severe community acquired pneumonia is not well known.

Objective

-The aim of this study was to estimate the median time to recovery and its predictors among severe community acquired pneumonia patients admitted to pediatric ward, Debre Markos Referral Hospital, North West Ethiopia.

Methods

- An institution based retrospective follow up study was employed among 352 records of children who were admitted starting from January 2016 to December, 2018. Patients chart were retrieved using a structured data extraction tool. Data was entered using Epi-Data version 3.02 and analyzed using STATA version 14 statistical software. The Kaplan Meier survival curve and log rank tests were used. Cox proportional hazard model assumption and model fitness were checked. Stratified Cox regression was fitted as a final model. Hazard ratio with its 95% confidence interval was used and P-value < 0.05 was considered as statistically significant association.

Result-

The overall median recovery time was 4 days IQR (3-7). Recovery rate from severe community acquired pneumonia was 16.25 (95% CI: 14.54–18.15) per 100 person day observation. Age (AHR; 0.94 95% CI (0.90-0.98)), being stunted (AHR; 0.62 95% CI (0.43-0.91)), presence of danger sign at admission (AHR; 0.61 95% CI ((0.40-0.94)), late presentation to seek care (AHR; 0.64 95% CI (0.47-0.88)) and co-morbidity (AHR; 0.45 95% CI ((0.45(0.35-0.58)) were significant predictors of recovery time.
Conclusion: The median recovery time from severe community acquired pneumonia was long. Measures to reduce recovery time should be strengthened.
Key words:-pediatrics, predictors, severe community acquired pneumonia and time to recovery.
CAIX is a predictor of pathological complete response and is associated with higher survival in locally advanced breast cancer submitted to neoadjuvant chemotherapy
Authors: Alves Wilson Eduardo Furlan Matos , Bonatelli Murilo , Dufloth Rozany , Kerr Lígia Maria , Carrara Guilherme Freire Angotti , Costa Ricardo Filipe Alves da , Scapulatempo-Neto Cristovam , Tiezzi Daniel , Vieira René Aloísio da Costa , Pinheiro Céline 
Published: August 2019

Abstract
Background

Locally advanced breast cancer often undergoes neoadjuvant chemotherapy (NAC), which allows in vivo evaluation of the therapeutic response. The determination of the pathological complete response (pCR) is one way to evaluate the response to neoadjuvant chemotherapy. However, the rate of pCR differs significantly between molecular subtypes and the cause is not yet determined. Recently, the metabolic reprogramming of cancer cells and its implications for tumor growth and dissemination has gained increasing prominence and could contribute to a better understanding of NAC. Thus, this study proposed to evaluate the expression of metabolism-related proteins and its association with pCR and survival rates.

Methods

The expression of monocarboxylate transporters 1 and 4 (MCT1 and MCT4, respectively), cluster of differentiation 147 (CD147), glucose transporter-1 (GLUT1) and carbonic anhydrase IX (CAIX) was analyzed in 196 locally advanced breast cancer samples prior to NAC. The results were associated with clinical-pathological characteristics, occurrence of pCR, disease-free survival (DFS), disease-specific survival (DSS) and overall survival (OS).

Results

The occurrence of pCR was higher in the group of patients whith tumors expressing GLUT1 and CAIX than in the group without expression (27.8% versus 13.1%, p = 0.030 and 46.2% versus 13.5%, p = 0.007, respectively). Together with regional lymph nodes staging and mitotic staging, CAIX expression was considered an independent predictor of pCR. In addition, CAIX expression was associated with DFS and DSS (p = 0.005 and p = 0.012, respectively).

Conclusions

CAIX expression was a predictor of pCR and was associated with higher DFS and DSS in locally advanced breast cancer patients subjected to NAC.
In silico prediction of structural and functional effects of the E71G mutation on GARS and its role in CMT2D and HMN5A pathogenesis
Authors: Garcia Ericka Mae , Mea Angelica , Frio Enrique Jose , Endriga Marla 
Published: August 2019

Abstract
Background The E71G mutation in GARS results in Charcot-Marie-Tooth disease type 2D (CMT2D) with overlapping distal hereditary motor neuropathy type 5A (HMN5A) phenotype, but the pathogenesis is unclear. This study aimed to predict the structural and functional effects of this mutation on GARS’ interaction with some of its putative or actual ligands in relation to CMT2D and HMN5A manifestation. Methods Putative or actual ligands of GARS were identified from 10 protein databases using Cytoscape 3.4.0. Thirty-one (31) ligands met our criteria and were selected for the study. GRAMM-X was utilized for docking simulations. The RMSD value difference between wild-type and docked ligands, change in binding free energy, and changes in interface between wild type and native GARS were analyzed. Results Our in silico analysis showed that GARS interaction with 19 distinct putative or actual ligands increased in stability, 10 decreased in stability, and two (2) were unchanged energetically. Data mining and network analysis showed that the ligands are involved in apoptosis, autophagy, and immune response, as well as the ubiquitin proteasome system and NGF/TrkA signaling. Conclusions These findings indicate that several biological processes (apoptosis, autophagy, and immune response) and pathways (ubiquitin proteasome system and NGF/TrkA signaling) may be affected by the E71G mutation. This suggests that GARS is a key molecule in CMT2D and HMN5A pathogenesis and shows promise as a target for novel drugs. Further experimentation is needed to verify these findings.