bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in gene expression in chronic allergy mouse model exposed to natural environmental PM2.5-rich ambient air pollution
Authors: Ouyang Yuhui , Xu Zhaojun , Fan Erzhong , Li Ying , Miyake Kunio , Xu Xianyan , Zhang Luo 
Published: April 2018

AbstractParticulate matter (PM) air pollution has been associated with an increase in the incidence of chronic allergic diseases; however, the mechanisms underlying the effect of exposure to natural ambient air pollution in chronic allergic diseases have not been fully elucidated. In the present study, we aimed to investigate the cellular responses induced by exposure to natural ambient air pollution, employing a mouse model of chronic allergy. The results indicated that exposure to ambient air pollution significantly increased the number of eosinophils in the nasal mucosa. The modulation of gene expression profile identified a set of regulated genes, and the Triggering Receptor Expressed on Myeloid cells1(TREM1) signaling canonical pathway was increased after exposure to ambient air pollution. In vitro, PM2.5 increased Nucleotide-binding oligomerization domain-containing protein 1 (Nod1) and nuclear factor (NF)-κB signaling pathway activation in A549 and HEK293 cell cultures. These results suggest a novel mechanism by which, PM2.5 in ambient air pollution may stimulate the innate immune system through the PM2.5-Nod1-NF-κB axis in chronic allergic disease.
Combining electrical stimulation and tissue engineering to treat large bone defects in a rat model
Authors: Leppik Liudmila , Zhihua Han , Mobini Sahba , Thottakkattumana Parameswaran Vishnu , Eischen-Loges Maria , Slavici Andrei , Helbing Judith , Pindur Lukas , Oliveira Karla M. C. , Bhavsar Mit B. , Hudak Lukasz , Henrich Dirk , Barker John H. 
Published: April 2018

AbstractBone Tissue engineering (BTE) has recently been introduced as an alternative to conventional treatments for large non-healing bone defects. BTE approaches mimic autologous bone grafts, by combining cells, scaffold, and growth factors, and have the added benefit of being able to manipulate these constituents to optimize healing. Electrical stimulation (ES) has long been used to successfully treat non-healing fractures and has recently been shown to stimulate bone cells to migrate, proliferate, align, differentiate, and adhere to bio compatible scaffolds, all cell behaviors that could improve BTE treatment outcomes. With the above in mind we performed in vitro experiments and demonstrated that exposing Mesenchymal Stem Cells (MSC) + scaffold to ES for 3 weeks resulted in significant increases in osteogenic differentiation. Then in in vivo experiments, for the first time, we demonstrated that exposing BTE treated rat femur large defects to ES for 8 weeks, caused improved healing, as indicated by increased bone formation, strength, vessel density, and osteogenic gene expression. Our results demonstrate that ES significantly increases osteogenic differentiation in vitro and that this effect is translated into improved healing in vivo. These findings support the use of ES to help BTE treatments achieve their full therapeutic potential.
The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization
Authors: Lindström Lisa , Li Tongbin , Malycheva Darina , Kancharla Arun , Nilsson Helén , Vishnu Neelanjan , Mulder Hindrik , Johansson Martin , Rosselló Catalina Ana , Alvarado-Kristensson Maria 
Published: April 2018

AbstractIn the cell, γ-tubulin establishes a cellular network of threads named the γ-string meshwork. However, the functions of this meshwork remain to be determined. We investigated the traits of the meshwork and show that γ-strings have the ability to connect the cytoplasm and the mitochondrial DNA together. We also show that γ-tubulin has a role in the maintenance of the mitochondrial network and functions as reduced levels of γ-tubulin or impairment of its GTPase domain disrupts the mitochondrial network and alters both their respiratory capacity and the expression of mitochondrial-related genes. By contrast, reduced mitochondrial number or increased protein levels of γ-tubulin DNA-binding domain enhanced the association of γ-tubulin with mitochondria. Our results demonstrate that γ-tubulin is an important mitochondrial structural component that maintains the mitochondrial network, providing mitochondria with a cellular infrastructure. We propose that γ-tubulin provides a cytoskeletal element that gives form to the mitochondrial network.
The CFHQSIR survey: a Y-band extension of the CFHTLS-Wide survey
Authors: Pipien S. , Basa S. , Cuby J.-G. , Cuillandre J.-C. , Willott C. , Moutard T. , Chatron J. , Arnouts S. , Hudelot P. 
Published: April 2018

Context. The Canada–France–Hawaii Telescope Legacy Survey (CFHTLS) has been conducted over a 5-yr period at the CFHT with the MegaCam instrument, totaling 450 nights of observations. The Wide Synoptic Survey is one component of the CFHTLS, covering 155 square degrees in four patches of 23 to 65 square degrees through the whole MegaCam filter set (u*, g’, r’, i’, z’) down to i’AB = 24.5.
Aims. With the motivation of searching for high-redshift quasars at redshifts above 6.5, we extend the multi-wavelength CFHTLS-Wide data in the Y -band down to magnitudes of ~22.5 for point sources (5σ).
Methods. We observed the four CFHTLS-Wide fields (except one quarter of the W3 field) in the Y -band with the Wide-field InfraRed Camera (WIRCam) at the CFHT. Each field was visited twice, at least three weeks apart. Each visit consisted of two dithered exposures. The images are reduced with the Elixir software used for the CFHTLS and modified to account for the properties of near-InfraRed (IR) data. Two series of image stacks are subsequently produced: four-image stacks for each WIRCam pointing, and one-square-degree tiles matched to the format of the CFHTLS data release. Photometric calibration is performed on stars by fitting stellar spectra to their CFHTLS photometric data and extrapolating their Y -band magnitudes.
Results. After corrections accounting for correlated noise, we measure a limiting magnitude of YAB ≃ 22.4 for point sources (5σ) in an aperture diameter of 0.′′93, over 130 square degrees. We produce a multi-wavelength catalogue combining the CFHTLS-Wide optical data with our CFHQSIR (Canada–France High-z quasar survey in the near-InfraRed) Y -band data. We derive the Y -band number counts and compare them to the Vista Deep Extragalactic Observations survey (VIDEO). We find that the addition of the CFHQSIR Y -band data to the CFHTLS optical data increases the accuracy of photometric redshifts and reduces the outlier rate from 13.8% to 8.8% in the redshift range 1.05 ≲ z ≲ 1.2.
Mit Vollwert-Ernährung die Lebensqualität steigern
Authors: Männle Thomas 
Published: April 2018

ZusammenfassungSich vollwertig zu ernähren, bedeutet schmackhaft, gesund und nachhaltig zu essen. Sieben einfache Grundsätze bieten Handlungshilfen, mit denen sich dieses Konzept im Alltag umsetzen lässt. Dazu gehört es: genussvolle und bekömmliche Speisen zu essen sowie pflanzliche, möglichst gering verarbeitete, fair gehandelte und ökologisch erzeugte Lebensmittel zu bevorzugen sowie auf regionale und saisonale Erzeugnisse zu setzen und ressourcenschonend zu haushalten.
Ernährung in der chinesischen Medizin
Authors: Siedentopp Uwe 
Published: April 2018

SummaryDie chinesische Ernährung und Diätetik bietet Arzt und Patienten die Möglichkeit, aktiv für die Gesunderhaltung zu wirken, Befindlichkeitsstörungen zu beseitigen und Krankheitsprozesse auf dem Weg der Heilung wirksam zu unterstützen. Es wird nicht unterschieden zwischen gesunden und ungesunden Lebensmitteln, da die Auswahl, Zubereitung und Kombination immer nach individuellen Bedürfnissen erfolgt. Die therapeutische Wirkung beruht auf den spezifischen, qualitativen Eigenschaften der Lebensmittel. Die Prinzipien der chinesischen Ernährung und Diätetik werden flexibel und undogmatisch angewandt. Sie lassen sich problemlos mit den in Deutschland heimischen Nahrungsmitteln und Getränken im Alltag umsetzen.
Die ketogene Diät – was sie kann, wie sie wirkt und wie sie gelingt
Authors: Bahr Lina , Bellmann-Strobl Judith , Michalsen Andreas 
Published: April 2018

ZusammenfassungKetogene Diät bedeutet Kohlenhydratverzicht. Bei Epilepsie ist sie seit 100 Jahren etabliert. Bei Diabetes Typ 2 kann sie eine echte Alternative sein, da sie schnell zur Gewichtsreduktion führt, der Blutzucker konstant bleibt und Insulinspitzen vermieden werden. Vielversprechende Ergebnisse haben aktuelle Forschungsarbeiten ergeben bei Multipler Sklerose, Alzheimer und Krebs als begleitende Therapiemaßnahme.Die Autoren geben einen überblick zu den möglichen Wirkmechanismen, den Indikationen sowie zur Umsetzung in der Praxis.
Ernährung nach F.X. Mayr
Authors: Sartor Henning 
Published: April 2018

SummaryBei der Ernährung nach F.X. Mayr handelt es sich um ein umfassendes, individuelles Therapiekonzept zur Vorbeugung und Behandlung von chronischen Erkrankungen. Dabei werden nach differenzierter, klinischer und heutzutage auch labortechnischer Diagnostik die Prinzipien der Schonung, Säuberung, Schulung und Substitution angewandt. Ernährung nach F.X. Mayr bedeutet eine dauerhafte Änderung des Einkaufs- und Essverhaltens und ist dann zur lebenslangen Prävention bzw. Sekundär-Prävention geeignet.
„Im Zentrum ein Feuer“
Authors: Stapelfeldt Elmar 
Published: April 2018

SummaryAnders als die westliche Ernährungstherapie unterscheidet die Ernährungstherapie der Ayurveda-Medizin nicht zwischen gesund – ungesund, sondern geeignet – ungeeignet. Der Ayurveda-Ansatz richtet sich nach der individuellen Situation, der Symptomatik sowie weiteren Faktoren wie Resorbierbarkeit von Nahrungsmitteln, Ausscheidbarkeit ihrer Rückstände und ihrem spezifischen Bezug zu einzelnen Geweben. Im Zentrum steht das Verdauungsfeuer agni – die Gesamtheit von Substanzen und Prozessen, die für die Digestion und Verstoffwechselung der Nahrung zuständig sind. In der Praxis bedeutet dies, im ersten Schritt agni zu entlasten und erst im zweiten Schritt eine spezielle Ernährungstherapie durchzuführen.Besonders bei gastrointestinalen Beschwerden zeigt die ayurvedische Ernährungstherapie sehr gute und mitunter sehr rasche Erfolge. Das Vorgehen in der Praxis wird am Beispiel des Reizdarmsyndroms vorgestellt.
Evaluating Stiffness of Fibreglass and Thermoplastic Splint Materials and Inter-fragmentary Motion in a Canine Tibial Fracture Model
Authors: Wagoner Amanda , Allen Matthew , Zindl Claudia , Litsky Alan , Orsher Robert , Ben-Amotz Ron 
Published: April 2018

Objectives Various materials are used to construct splints for mid-diaphyseal tibial fracture stabilization. The objective of this study was to compare construct stiffness and inter-fragmentary bone motion when fibreglass (FG) or thermoplastic (TP) splints are applied to either the lateral or cranial aspect of the tibia in a mid-diaphyseal fracture model.
Methods A coaptation bandage was applied to eight cadaveric canine pelvic limbs, with a custom-formed splint made of either FG or TP material applied to either the lateral or cranial aspect of the osteotomized tibia. Four-point bending tests were performed to evaluate construct stiffness and inter-fragmentary motion in both frontal and sagittal planes.
Results For a given material, FG or TP, construct stiffness was not affected by splint location. Construct stiffness was significantly greater with cranial FG splints than with cranial TP splints (p < 0.05), but this difference was not significant when comparing splints applied laterally (p = 0.15). Inter-fragmentary motions in the sagittal and frontal planes were similar across splint types for cranial splints, but for lateral splints there was a 64% reduction in frontal plane motion when FG was used as the splint material (p = 0.03).
Clinical Significance FG produces a stiffer construct, but the difference is not reflected in a reduction in inter-fragmentary motion. For lateral splints, FG splints are associated with reduced inter-fragmentary motion as compared with TP and may therefore have slight superiority for this application.
Reparación del tendón extensor pollicis longus, mediante la técnica del lazo con el extensor pollicis brevis
Authors: Abad Morenilla José , Sutil Blanco Ángel , Varillas Delgado David , García de Lucas Fernando 
Published: April 2018

Introducción Se presenta una alternativa quirúrgica a las técnicas convencionales para reparación de lesiones por herida o por mecanismo cerrado del tendón EPL, denominada lazo transfixiante y contínuo; el cual emplea el tendón de anclaje motor procedente del músculo EPB (Extensor Pollicis Brevis). El objetivo fundamental del estudio fue explicar el desarrollo de esa técnica y los resultados satisfactorios que muestra en la reparación de las lesiones completas del EPL.
Material y método  Se describe un nuevo nudo, conocido como lazo transfixiante y continuo, el cual emplea el tendón de anclaje motor procedente del músculo EPB (Extensor Pollicis Brevis), uniendo el tendón EPL lesionado con el tendón EPB, envolviendo a éste, sin desinsertar la unidad motora del EPB, recuperando con ello la función extensora del primer dedo de la mano. Se seleccionó una serie de 10 casos de rotura del EPL reparados con esa técnica, en contexto de accidente laboral. Se tomaron como variables; edad, profesión, sexo, lateralidad, dominancia, mecanismo lesional, momento de la intervención y presencia de lesiones asociadas. Seis de los casos se produjeron por mecanismo lesional cerrado (60%), y los 4 casos restantes mediante herida (40%).
Resultados. Al finalizar el proceso, 9 pacientes presentaron como resultado curado (90%), mientras que sólo 1 de ellos resultado baremo (10%). No se observaron diferencias entre la extremidad sana y la extremidad operada en movilidad y en cuanto a resultados funcionales mediante tres mediciones; prensión, pinza terminoterminal y pinza lateral.
Discusión el lazo continuo transfixiante para la reparación de lesiones del tendón EPL empleando el tendón EPB es un procedimiento que genera un rango funcional efectivo. Aporta unos resultados satisfactorios, en cuanto a la funcionalidad objetivada a través de test biomecánicos, alcanzando adecuada tasa de reincorporación laboral.
Transatlantic Air Travel in the Third Trimester of Pregnancy: Does It Affect the Fetus?
Authors: Petrikovsky B. , Terrani M. , Sichinava L. 
Published: April 2018

AbstractMost commercial airlines allow pregnant women to fly up to 36 weeks of gestation. Available information suggests that noise, vibration, and cosmic radiation present a small risk for the pregnant air traveler. The goal of the study was to assess the possible effect of transatlantic flights on the condition of the third-trimester fetus. In total, 112 patients were recruited into the study between January 2005 and June 2016. All underwent a transatlantic flight in the third trimester of pregnancy. All underwent nonstress test before and within 12 hours after the transatlantic flight, and 24 hours later. Patients were asked to report changes in fetal movements (FMs), if any, during takeoff, flight itself, and landing. The time of flight varied from 8 to 15 hours; average flight time was 9 ± 3.8 hours. Ninety-eight patients were the passengers of first or business class, and the rest were of economy class. Increased FM during takeoff was reported by 17 patients (15%), no change in FM by 62 (35%), decreased FM by 4 (3.6%). During flight itself, increased FM was reported by 6 pregnant passengers (5.4%), no change in FM by 70 (63%), decreased FM by 8 (7%).
Omental Vascularized Lymph Node Flap: A Radiographic Analysis
Authors: Sasor Sarah , Tholpady Sunil , Chu Michael , Cook Julia 
Published: April 2018

Background Vascularized lymph node transfer is an increasingly popular option for the treatment of lymphedema. The omental donor site is advantageous for its copious soft tissue, well-defined collateral circulation, and large number of available nodes, without the risk of iatrogenic lymphedema. The purpose of this study is to define the anatomy of the omental flap in the context of vascularized lymph node harvest.
Methods Consecutive abdominal computed tomography angiography (CTA) images performed at a single institution over a 1-year period were reviewed. Right gastroepiploic artery (RGEA) length, artery caliber, lymph node size, and lymph node location in relation to the artery were recorded. A two-tailed Z-test was used to compare means. A Gaussian Mixture Model confirmed by normalized entropy criterion was used to calculate three-dimensional lymph node cluster locations along the RGEA.
Results In total, 156 CTA images met inclusion criteria. The RGEA caliber at its origin was significantly larger in males compared with females (p < 0.001). An average of 3.1 (1.7) lymph nodes were present per patient. There was no significant gender difference in the number of lymph nodes identified. Average lymph node size was significantly larger in males (4.9 [1.9] × 3.3 [0.6] mm in males vs. 4.5 [1.5] × 3.1 [0.5] mm in females; p < 0.001). Three distinct anatomical variations of the RGEA course were noted, each with a distinct lymph node clustering pattern. Total lymph node number and size did not differ among anatomical subgroups.
Conclusion The omentum is a reliable lymph node donor site with consistent anatomy. This study serves as an aid in preoperative planning for vascularized lymph node transfer using the omental flap.
Re-assessing the ‘weight’ of translations within the context of translated soap operas
Authors: Okyayuz Şirin 
Published: April 2018

Abstract
In translation studies, investigating translations beyond the implications, realities and difficulties of single texts and single
language combinations, viewing the larger picture surrounding translations and following the translations through to the impacts
they produce wherever they are received, is an integral part of the discipline. The study discussed in this article is an effort
to present food for thought for audiovisual translators of soap operas. Turkish soap operas have been aired in 90 countries around
the world, reaching over 400 million viewers, according to 2014 statistics from the sector. The aim of the study is to indicate
the type of translated soap operas preferred in different regions of the world; to explain, on the basis of feedback from experts,
the public and local and international media, why these are watched; and to investigate the translation modes and strategies used
to market the translations successfully in the receiver markets.
Lugares comunes de la traducción en la Edad Media y Moderna
Authors: García Gavín Santiago 
Published: April 2018

Résumé
L’objectif de cet article est d'examiner le rôle littéraire de la traduction dans la mesure où elle se réfère à un changement dans
le concept de littérature. Ce paradigme remonte à la légitimité des sources anciennes et s’étend jusqu’à l’exigence de
l’originalité de la création littéraire, qui s’échelonne entre l'époque médiévale et les Temps modernes. Alors qu'à l’époque
médiévale, la traduction était considérée comme un processus productif qui soutenait « l’auctoritas » et faisait partie de la
vérité symbolique, pendant les Temps modernes, son rôle était de préserver la fiction d’authenticité demandée par un auteur.
L’introduction de l’innovation culturelle et littéraire joue également un rôle ici, de même que la distanciation de la fable et la
figure rhétorique paradoxale.
Lost in translation
Authors: Wook-Dong Kim 
Published: April 2018

Abstract
This paper explores how translation of foreign film titles has been carried out in South Korea since foreign films first arrived in
Korea following its emancipation from Japanese colonial rule. With reference to audiovisual translation in general and film or
screen translation in particular, this paper discusses the extent of the mistakes made by Korean translators due to a lack of
thorough contextual knowledge of the source language and culture. Most Korean translations of foreign films result in strange,
surreal, and at best funny adaptations. Discussion regarding “bad,” total, or almost total mistranslations focuses on (1) words
with multiple meanings (homonyms and heteronyms); (2) slang and colloquial expressions; (3) words with culturally specific
features; and (4) proper nouns and common nouns. This paper concludes that in an era of globalization, film title translation in
Korea increasingly shows a trend towards transliteration rather than translation – either literal or liberal.
Neardone;awfulstable;reallychanging
Authors: Tagliamonte Sali A. 
Published: April 2018

AbstractThis paper examines adverb formation with-ly, e.g.,slow/slowly, and uses a large archive of synchronic dialects to uncover the current state and historical trajectory of this process. The results reveal that English adverbs are a variegated system. The intensifying adverbreallyis a frequent form while sentential adverbs appear to be a newer layer in the system. In contrast, manner adverbs are constrained by the semantic interpretation of the adverb as abstract or concrete. These results expose the complexity of the English adverb system and demonstrate that adverb formation is an ideal site for uncovering historical processes in synchronic data.
Irony in a theory of textual meaning
Authors: Jeffries Lesley 
Published: April 2018

Abstract
This chapter attempts to map out different types of irony, using a model of communication which encompasses a range of potential meaning including linguistic, textual, interpersonal and situational meaning. It is argued that the resulting description of potentially ironic examples can help to show where apparently different types have overlap. It also attempts to demonstrate the boundaries of irony in relation to linguistic humour more generally and to articulate some of the distinctions between irony and other forms of apparent clash such as paradox and hypocrisy. The chapter concludes that irony can occur without intention and despite, not because of, an audience, though both intentionality and addressee(s) are needed for the most recognisable forms of verbal irony.
Verbal irony, politeness… and three ironic types
Authors: Simonin Olivier 
Published: April 2018

Abstract
This paper critically examines Leech’s (2014) view that verbal or conversational irony is subsumed by politeness considerations, and proposes a new, threefold account of verbal irony. Although Leech’s pragmatic model of irony is inadequate as a whole, it highlights crucial aspects of irony relating to (im)politeness theory. I propose an alternative account of verbal irony that first recognizes two major types, polar irony and impersonation irony, which have been referred to in the literature under various denominations, including oppositional irony and echoic irony (Simpson 2011). In polar irony, a desirable state of affairs is evoked that is blatantly contradicted by facts; in impersonation irony, the speaker takes up someone else’s viewpoint or an assumed identity to ridicule targets or victims of the irony. Building on Leech’s observations, I argue that a last type should be added,
mock politeness irony, noting that the three types of verbal irony can combine. In the course of the discussion I review psycholinguistic data, other conceptions of irony, and the connection between politeness, irony and banter.