bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demarcating Sweet Spots in Cambay Shale by Integrating Rock Eval Pyrolysis, Geomechanics and Seismic Data
Authors: Sharma Vaishali , Sircar Anirbid 
Published: November 2018

Abstract
Unconventional shale oil/gas has been envisaged as one of the most promising resources of India. India is having enormous untapped shale oil/gas potential of 96 TCF risked technically recoverable shale gas and 3.8 billion barrel risked technically recoverable shale oil. But, its development is still nascent and not very much conducive due to insufficient data availability and limited exploration and exploitation activities. The present study is an attempt to minimize the existing data gap and providing useful information pertaining to shale geochemistry, sweet spots delineation, geomechanics and fracability. Shale has an important feature of acting as both source as well as reservoir for hydrocarbon generation, expulsion and accumulation. Demarcating sweet spots are helpful in identifying these prospective hydrocarbons bearing zones in shales and hence in locating favorable drilling targets. High content of organic matter, kerogen richness, clay content, shale geomechanics are the key parameters that affect sweet spots distribution in shale and so the generation of hydrocarbons. In the present work, a link from the hydrocarbon enriched zones (i.e. Sweet Spots) of Cambay Basin to its seismic attributes has been created and parameters like - thermal maturity, organic richness, kerogen typing, shale geomechanics, fracability and brittleness index of Cambay Shale are experimentally determined using characterization techniques - Rock Eval Pyrolysis, FTIR and Geomechanical Analysis. Sweet spots were identified in the deeper formation of Cambay Basin. The shale is thermally mature, organically rich and have good potential of hydrocarbon generation. However, from the fracability point of view, the selected section is geomechanically weak and may be unfavourable for advance stimulation.
Faster and Profitable Production Optimization Decisions through Workflow Automation and Business Process Management - A Unique Concept
Authors: Khan Muhammad Navaid , Al Neaimi Ahmed Khaleefa , Al Qamzi Abdullah , Ali Yusaf Shabbeer , Shimizu Yasushi , Asghar Ali , Felix Menchaca Tania 
Published: November 2018

Abstract
Operational efficiency improvement is a fundamental requirement and the continuous effort to achieve it is the inevitable need for any organization that targets profitable throughput in today's volatile market. Based on a study for a group of North American oilfields, in a typical mature oilfield, on an average 6% to 10% production deferments are caused by the process inefficiencies. Organizations continuously look for cost effective technologies that can facilitate implementing systematic operating procedures to maximize value of available resources and to provide a controlled environment for executing defined activities efficiently.
Business process management (BPM) is a technique that brings in a governance mechanism to the efficient execution of processes. It uses various methods to discover, model, analyze, measure, improve, optimize, and automate business process to generate and track improvement actions. A typical project implementation involves a holistic review of the existing processes, identifications of the bottlenecks, mapping of the stakeholders and developing definitions for efficient corrective actions that enable closing system gaps. Early engagement with the stakeholders and an insightful management of change (MOC) are the key requisites of assuring the successful process roll out.
Despite many industries, such as, medical and financial institutions, human capital management firms and logistics tracking system providers, have exploited the use of BPM and workflow automation to enhance their operation management capabilities, oil and gas industry still lags behind in capitalizing the benefits of this useful combination. This paper demonstrates the stepwise approach of implementing effective strategies, methods, and techniques to model and roll out collaborative solutions to help multi-disciplinary teams to execute business processes efficiently and consistently, whilst ensuring adherence to standards and agreed guidelines for maximizing efficiency and profitability. A real implementation case is presented, where a complex integrated production management and optimization system is managed leveraging workflow automation and BPM that has resulted in significant efficiency gain.
Stress Field Inversion from Advanced Geomechanics Modeling and its Application to Understand Fluid Flow Behavior in Fractured Environments
Authors: Noufal Abdelwahab , Obaid Khalid , Al Blooshi Abdulla , Basioni Mahmoud , Nehaid Hani , Guerra Julian , Liu Yaxin 
Published: November 2018

Abstract
The stress field is a complex variable that affects all drilling operations, completions and reservoir performance. From the three components of a non-rotated stress field, the maximum horizontal stress is the more difficult variable to model since cannot be directly measured and involves multiple unknowns. This study presents an advanced geomechanics modeling technique to estimate the most likely horizontal stresses by integrating advanced acoustic measurements, multi-well image interpretation and geomechanics back analysis.
The study was carried out in SR wells, a new development zone in the UAE, which targets the fractured and medium porosity reservoirs rocks of Late Permian formation. The estimation of the stress field is necessary not only for well planning but also to understand the occurrence of abundant drilling induced fractures that sometimes mask the natural ones. It will help also to propose location of possible fracture treatments while analyzing possible relationships between fluid flow and the presence of critically stressed fractures.
The horizontal stress field was inverted from advanced geomechanics modeling including the elimination of the gas effect, inversion of Shmax from 3-Shear moduli analysis in stress sensitive intervals, image interpretation for stress related and intrinsic features, determination of stress regime Q-factor from Integrated Stress Analysis (ISA) and performing a failure analysis to validate the stress field and calibrating the overall geomechanical model. The calculated maximum horizontal stress from 3-Shear moduli, ISA and failure analysis proved to be consistent in both SR wells, where the Normal stress regime agreed with current structural framework and local geology. The stress direction was also consistent among measurements, although some local stress rotations were observed in specific zones. High angle features such as drilling induced and natural fractures were also consistent with the modeled stress field, where the vertical stress is the maximum principal stress. Mud losses were mainly attributed to the presence of vugs, conductive seams and fracture corridors rather than induced fracturing.
The inverted stress field was finally used as input in the Completion Advisor and Fracture Stability workflows and then compared against PLT data in. The results show a good correlation between critically stressed fractures and well productivity in SR wells. The last could lead to optimize the completion strategy in future wells by selecting best intervals for perforating and stimulation based in this integrated approach.
Duszpasterstwo lotnictwa cywilnego. Wskazania pastoralno-kanoniczne
Authors: NECEL WOJCIECH 
Published: November 2018

Omawiany dokument (Catholic Civil Aviation Pastoral Directives) jest wyrazem troski Kościoła o wiernych w ich konkretnych sytuacjach życiowych i zawodowych. Wskazania kanoniczno-duszpasterskie zawarte w Directives mają na celu określenie osób do których Duszpasterstwo Lotnictwa cywilnego jest skierowane, a Take odpowiedzialnych za tego rodzaju posługę duszpasterska oraz wskazać konieczne struktury służące tej formie działalności apostolskiej. Według wytycznych istotnym elementem działalności duszpasterskiej tak na lotniskach krajowych jak i międzynarodowych jest otwarcie się na tych, do których ta forma apostolatu jest kierowana, jak i na wszystkich potrzebujących pomocy a przebywających na terenie portu lotniczego.
Reforma papieskich instytucji do spraw komunikacji społecznej
Authors: KAMIŃSKI RAFAŁ 
Published: November 2018

Wraz z pojawieniem się nowego środka przekazu jakim stał się film i upowszechnieniem się na świecie kinematografii, w Kościele wzrastała świadomość i potrzeba zainteresowania się nowymi technologiami oraz stworzenia w ramach struktur Stolicy Apostolskiej instytucjonalnej ochrony wiernych przed szkodliwym wpływem niewłaściwych treści, a także w celu propagowania treści pożytecznych.W tym celu na przestrzeni lat tworzono specjalne instytucje, które w strukturach Kurii Rzymskiej zajmowały się wprost problematyką mediów. Początkowo zadanie to podejmowała Papieska Komisja, która przez kilkanaście lat podlegała ciągłym modyfikacjom (od 1948 roku do 1964 roku), natomiast od 1964 roku do roku 2015 mieliśmy do czynienia z działaniami Papieskiej Rady Środków Społecznego Przekazu.Ostatnim reformatorskim akcentem na tym polu, jest powołanie przez Papieża Franciszka 27 czerwca 2015 roku Sekretariatu do spraw Komunikacji. Podobnie jak poprzedzające go instytucje do spraw komunikacji społecznej, w dalszym ciągu ma on współpracować w dziedzinie środków komunikacji społecznej z Sekretariatem Stanu, jednocząc w sobie wszystkie instytucje medialne Stolicy Apostolskiej.
Cancer Biology Aspects of Computational Methods & Applications in Drug Discovery
Authors: Chien Shang-Tao , Kumar Ajay , Pandey Shifa , Yen Chung-Kun , Wang Shao-Yu , Wen Zhi-Hong , Kaushik Aman C. , Shiue Yow-Ling , Pan Cheng-Tang 
Published: November 2018

Background:
Cancer is one of the most debilitating diseases worldwide; even though advances in
molecular and cellular biology have contributed to the decline of mortality associated with cancer, the procedure
of drug discovery and development of cancer are time-consuming and expensive. However, with computer-aided
drug discovery (CADD) techniques, pharmaceutical firms can save production costs and reduce the time of introducing
effective anticancer drugs for clinical trials. CADD strategies like structure-based drug designing, ligandbased
drug designing, and combined structure-based and ligand-based approaches also have the advantage of
identifying target sites and discovering active compounds with high affinity for the target sites. In this article,
research carried out on cancer biology aspect of the computational approaches in drug discovery technology have
been reviewed.

Objective:
The main objective of the study is to identify the potential causes and the development of the cancer.
In addition to this, its recovery has been discussed briefly.

Conclusion:
Our findings indicate that only a few studies have been carried out regarding this area. Hence, it is
recommended that further researches should be conducted on the computational methods for identifying candidate
drugs for breast, pancreatic, colon, prostate, and other types of cancer.
Machine Learning Methods in Precision Medicine Targeting Epigenetic Diseases
Authors: Fan Shijie , Chen Yu , Luo Cheng , Meng Fanwang 
Published: November 2018

Background:
On a tide of big data, machine learning is coming to its day. Referring to huge amounts
of epigenetic data coming from biological experiments and clinic, machine learning can help in detecting epigenetic
features in genome, finding correlations between phenotypes and modifications in histone or genes, accelerating
the screen of lead compounds targeting epigenetics diseases and many other aspects around the study on
epigenetics, which consequently realizes the hope of precision medicine.

Methods:
In this minireview, we will focus on reviewing the fundamentals and applications of machine learning
methods which are regularly used in epigenetics filed and explain their features. Their advantages and disadvantages
will also be discussed.

Results:
Machine learning algorithms have accelerated studies in precision medicine targeting epigenetics diseases.

Conclusion:
In order to make full use of machine learning algorithms, one should get familiar with the pros and
cons of them, which will benefit from big data by choosing the most suitable method(s).
The Cytotoxicity and Synergistic Potential of Aspirin and Aspirin Analogues Towards Oesophageal and Colorectal Cancer
Authors: Kilari Rajagopal S. , Bashir Asma’u I.J. , Devitt Andreue , Perry Christopher J. , Safrany Stephen T. , Nicholl Iain D. 
Published: November 2018

Background:Oesophageal cancer (OC) is a deadly cancer because of its aggressive nature with survival rates that have barely improved in decades. Epidemiologic studies have shown that low-dose daily intake of aspirin can decrease the incidence of OC.Methods:The toxicity of aspirin and aspirin derivatives to OC and a CRC cell line were investigated in the presence and absence of platins.Results:The data in this study show the effects of a number of aspirin analogues and aspirin on OC cell lines that originally presented as squamous cell carcinoma (SSC) and adenocarcinoma (ADC). The aspirin analogues fumaryldiaspirin (PN517) and the benzoylsalicylates (PN524, PN528 and PN529), were observed to be more toxic against the OC cell lines than aspirin. Both quantitative and qualitative apoptosis experiments reveal that these compounds largely induce apoptosis, although some necrosis was evident with PN528 and PN529. Failure to recover following the treatment with these analogues emphasized that these drugs are largely cytotoxic in nature. The OE21 (SSC) and OE33 (ADC) cell lines were more sensitive to the aspirin analogues compared to the Flo-1 cell line (ADC). A non-cancerous oesophageal primary cells NOK2101, was used to determine the specificity of the aspirin analogues and cytotoxicity assays revealed that analogues PN528 and PN529 were selectively toxic to cancer cell lines, whereas PN508, PN517 and PN524 also induced cell death in NOK2101. In combination index testing synergistic interactions of the most promising compounds, including aspirin, with cisplatin, oxaliplatin and carboplatin against the OE33 cell line and the SW480 colorectal cancer (CRC) cell line were investigated. Compounds PN517 and PN524, and to a lesser extent PN528, synergised with cisplatin against OE33 cells. Cisplatin and oxaliplatin synergised with aspirin and PN517 when tested against the SW480 cell line.Conclusion:These findings indicate the potential and limitations of aspirin and aspirin analogues as chemotherapeutic agents against OC and CRC when combined with platins.
Peptide R18H from BRN2 Transcription Factor POU Domain Displays Antitumor Activity In Vitro and In Vivo and Induces Apoptosis in B16F10-Nex2 Cells
Authors: da Cunha Fernanda F.M. , Mugnol Katia C.U. , de Melo Filipe M. , Nascimento Marta V.S.Q. , de Azevedo Ricardo A. , Santos Raquel T.S. , Magalhães Jéssica A. , Miguel Danilo C. , Tada Dayane B. , Mortara Renato A. , Travassos Luiz R. , Arruda Denise C. 
Published: November 2018

Background:BRN2 transcription factor is associated with the development of malignant melanoma. The cytotoxic activities and cell death mechanism against B16F10-Nex2 cells were determined with synthetic peptide R18H derived from the POU domain of the BRN2 transcription factor.Objective:To determine the cell death mechanisms and in vivo activity of peptide R18H derived from the POU domain of the BRN2 transcription factor against B16F10-Nex2 cells.Methods:Cell viability was determined by the MTT method. C57Bl/6 mice were challenged with B16F10-Nex2 cells and treated with R18H. To identify the type of cell death, we used TUNEL assay, Annexin V and PI, Hoechst, DHE, and determination of caspase activation and cytochrome c release. Transmission electron microscopy was performed to verify morphological alterations after peptide treatment.Results:Peptide R18H displayed antitumor activity in the first hours of treatment and the EC50% was calculated for 2 and 24h, being 0.76 ± 0.045 mM and 0.559 ± 0.053 mM, respectively. After 24h apoptosis was evident, based on DNA degradation, chromatin condensation, increase of superoxide anion production, phosphatidylserine translocation, activation of caspases 3 and 8, and release of extracellular cytochrome c in B16F10-Nex2 cells. The peptide cytotoxic activity was not affected by necroptosis inhibitors and treated cells did not release LDH in the extracellular medium. Moreover, in vivo antitumor activity was observed following treatment with peptide R18H.Conclusion:Peptide R18H from BRN2 transcription factor induced apoptosis in B16F10-Nex2 and displayed antitumor activity in vivo.
Poly (ADP-Ribose) Polymerases (PARPs) and PARP Inhibitor-Targeted Therapeutics
Authors: Li Nan , Wang Yifan , Deng Weiye , Lin Steven H. 
Published: November 2018

Background:Poly-ADP-ribosylation, that is, adding ADP-ribose moieties to a protein, is a unique type of protein post-translational modification that regulates various cellular processes such as DNA repair, mitosis, transcription, and cell growth. Small-molecule inhibitors of poly-ADP-ribose polymerase 1 (PARP1) have been developed as anticancer agents because inhibition of PARP enzymes may be a synthetic lethal strategy for cancers with or BRCA2 mutations. However, there are still questions surrounding PARP inhibitors.Methods/Results:Data were collected from Pubmed, Medline, through searching of these keywords: “PARP”, “BRCA”, “Synthetic lethal” and “Tankyrase inhibitors”. We describe the current knowledge of PARP inhibition and its effects on DNA damage; mechanisms of resistance to PARP inhibitors; the evolution of PARP inhibitors; and the potential use of PARP5a/b (tankyrases) inhibitors in cancer treatment.Conclusion:PARP inhibitors are already showing promise as therapeutic tools, especially in the management of BRCA-mutated breast and ovarian cancers but also in tumors with dysfunctional BRCA genes. Small-molecule tankyrase inhibitors are important for increasing our understanding of tankyrase biology.
Gender Moderates the Partial Mediation of Impulsivity in the Relationship Between Psychiatric Distress and Problematic Online Gaming: Online Survey
Authors: Su Wenliang , Király Orsolya , Demetrovics Zsolt , Potenza Marc N 
Published: November 2018

Background
Research has shown that some individuals can develop problematic patterns of online gaming, leading to significant psychological and interpersonal problems. Psychiatric distress and impulsivity have been suggested to contribute to problematic online gaming (POG).

Objective
This study aimed to investigate the potential mediating or moderating mechanisms of impulsivity and gender-related differences in possible associations between psychiatric distress and POG.

Methods
A total of 596 matched female and male participants, ranging in age from 14 to 38 years (mean 21.4, SD 4.5), were chosen from a large cross-sectional, nationwide Hungarian online gaming sample. Participants completed online questionnaires about self-reported impulsivity, psychiatric distress, and POG.

Results
Psychiatric distress directly predicted POG, and impulsivity partially mediated the relationship between psychiatric distress and POG. However, this mediation effect was found only for the impatience factor of impulsivity. Impulsivity did not moderate the relationship between psychiatric distress and POG. A moderating effect of gender was not found in the direct relationship between psychiatric distress and POG. However, a moderated mediation analysis revealed that impatience mediated the association between psychiatric distress and POG in males, whereas the indirect effect of impatience was not significant in females.

Conclusions
The results of this work highlight gender-related difference among online gamers in the mediation effect of impulsivity between psychiatric distress and POG and provide novel insights regarding clinical implications for preventing or treating POG.
Believing Is Seeing: A Proof-of-Concept Semiexperimental Study on Using Mobile Virtual Reality to Boost the Effects of Interpretation Bias Modification for Anxiety
Authors: Otkhmezuri Boris , Boffo Marilisa , Siriaraya Panote , Matsangidou Maria , Wiers Reinout W , Mackintosh Bundy , Ang Chee Siang , Salemink Elske 
Published: November 2018

Background
Cognitive Bias Modification of Interpretations (CBM-I) is a computerized intervention designed to change negatively biased interpretations of ambiguous information, which underlie and reinforce anxiety. The repetitive and monotonous features of CBM-I can negatively impact training adherence and learning processes.

Objective
This proof-of-concept study aimed to examine whether performing a CBM-I training using mobile virtual reality technology (virtual reality Cognitive Bias Modification of Interpretations [VR-CBM-I]) improves training experience and effectiveness.

Methods
A total of 42 students high in trait anxiety completed 1 session of either VR-CBM-I or standard CBM-I training for performance anxiety. Participants’ feelings of immersion and presence, emotional reactivity to a stressor, and changes in interpretation bias and state anxiety, were assessed.

Results
The VR-CBM-I resulted in greater feelings of presence (P<.001, d=1.47) and immersion (P<.001, ηp2=0.74) in the training scenarios and outperformed the standard training in effects on state anxiety (P<.001, ηp2=0.3) and emotional reactivity to a stressor (P=.03, ηp2=0.12). Both training varieties successfully increased the endorsement of positive interpretations (P<.001, drepeated measures [drm]=0.79) and decreased negative ones. (P<.001, drm=0.72). In addition, changes in the emotional outcomes were correlated with greater feelings of immersion and presence.

Conclusions
This study provided first evidence that (1) the putative working principles underlying CBM-I trainings can be translated into a virtual environment and (2) virtual reality holds promise as a tool to boost the effects of CMB-I training for highly anxious individuals while increasing users’ experience with the training application.