bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multicenter Prospective Phase II Trial of Neoadjuvant Dose-Dense Gemcitabine Plus Cisplatin in Patients With Muscle-Invasive Bladder Cancer
Authors: Iyer Gopa , Balar Arjun V. , Milowsky Matthew I. , Bochner Bernard H. , Dalbagni Guido , Donat S. Machele , Herr Harry W. , Huang William C. , Taneja Samir S. , Woods Michael , Ostrovnaya Irina , Al-Ahmadie Hikmat , Arcila Maria E. , Riches Jamie C. , Meier Andreas , Bourque Caitlin , Shady Maha , Won Helen , Rose Tracy L. , Kim William Y. , Kania Brooke E. , Boyd Mariel E. , Cipolla Catharine K. , Regazzi Ashley M. , Delbeau Daniela , McCoy Asia S. , Vargas Hebert Alberto , Berger Michael F. , Solit David B. , Rosenberg Jonathan E. , Bajorin Dean F. 
Published: May 2018

Purpose Neoadjuvant chemotherapy followed by radical cystectomy (RC) is a standard of care for the management of muscle-invasive bladder cancer (MIBC). Dose-dense cisplatin-based regimens have yielded favorable outcomes compared with standard-dose chemotherapy, yet the optimal neoadjuvant regimen remains undefined. We assessed the efficacy and tolerability of six cycles of neoadjuvant dose-dense gemcitabine and cisplatin (ddGC) in patients with MIBC. Patients and Methods In this prospective, multicenter phase II study, patients received ddGC (gemcitabine 2,500 mg/m2 on day 1 and cisplatin 35 mg/m2 on days 1 and 2) every 2 weeks for 6 cycles followed by RC. The primary end point was pathologic downstaging to non–muscle-invasive disease (< pT2N0). Patients who did not undergo RC were deemed nonresponders. Pretreatment tumors underwent next-generation sequencing to identify predictors of chemosensitivity. Results Forty-nine patients were enrolled from three institutions. The primary end point was met, with 57% of 46 evaluable patients downstaged to < pT2N0. Pathologic response correlated with improved recurrence-free survival and overall survival. Nineteen patients (39%) required toxicity-related dose modifications. Sixty-seven percent of patients completed all six planned cycles. No patient failed to undergo RC as a result of chemotherapy-associated toxicities. The most frequent treatment-related toxicity was anemia (12%; grade 3). The presence of a presumed deleterious DNA damage response (DDR) gene alteration was associated with chemosensitivity (positive predictive value for < pT2N0 [89%]). No patient with a deleterious DDR gene alteration has experienced recurrence at a median follow-up of 2 years. Conclusion Six cycles of ddGC is an active, well-tolerated neoadjuvant regimen for the treatment of patients with MIBC. The presence of a putative deleterious DDR gene alteration in pretreatment tumor tissue strongly predicted for chemosensitivity, durable response, and superior long-term survival.
Enhancing Performances of Hybrid Perovskite Light Emitting Diodes with Thickness Controlled PMMA Interlayer
Authors: Kumar Gundam Sandeep , Pradhan Bapi , Kamilya Tapas , Acharya Somobrata 
Published: May 2018

Abstract
Solution processed organic-inorganic halide perovskites emerged as efficient materials for the fabrication of light-emitting diodes (LEDs). Spin coating of perovskites on solid support for device integration leads to poor morphology with pinholes and leakage current through electrical shunt paths thereby decreasing the device efficiency. Here, we report a facile route to improve the performance of MAPbBr3 perovskite based LEDs by incorporating a poly(methyl methacrylate) (PMMA) interlayer in the device structure at the interface of ZnO and MAPbBr3 layer. The thickness of PMMA interlayer was varied to achieve optimal device performance by overcoming the leakage current and reduced non-radiative recombination pathways. LEDs with optimal PMMA thickness showed a significant enhancement in device performance comparison to the devices without PMMA interlayer. The perovskite LEDs with ∼7 nm PMMA interlayer exhibit a maximum luminance of ∼3450 cdm−2, current efficiency of ∼11.88 cdA−1, external quantum efficiency of ∼2.82% and power efficiency of ∼4.4 lmW−1 showing robust LED properties with ∼6-fold enhancement compared to a device without PMMA. Our route provides a convenient way to improve the efficiency of perovskite LEDs by controlling device structure with planar PMMA interlayer, which can be extended to other perovskite LEDs.
Molecular systematics of Caryopteris (Lamiaceae) and its allies with reference to the molecular phylogeny of subfamily Ajugoideae
Authors: Xiang Chun-Lei , Zhao Fei , Cantino Philip D. , Drew Bryan T. , Li Bo , Liu En-De , Soltis Douglas E. , Soltis Pamela S. , Peng Hua 
Published: May 2018

AbstractAjugoideae, the third–largest subfamily of Lamiaceae with 23 genera and about 760 species, is distributed worldwide, but is primarily found in tropical regions. During the past two decades, substantial progress has been made towards discerning phylogenetic relationships and generic boundaries in Ajugoideae, but major questions still remain. This phylogenetic study was conducted using 422 DNA sequences from seven DNA regions (nrITS, ETS, and matK, rbcL, rps16, trnL–trnF, trnH–psbA) representing 50 species from 22 of 23 genera in Ajugoideae, to reconstruct the backbone phylogeny of the subfamily, with emphasis on phylogenetic relationships among Caryopteris, Schnabelia and their closest allies. Key results: (1) Ajugoideae is monophyletic and can be divided into four main clades. (2) Discretitheca and Glossocarya, which have not been included in any previous molecular analysis, are members of Ajugoideae and closely related to Karomia and Rotheca. (3) Expanded Schnabelia is monophyletic, sister to Rubiteucris, and consists of two morphologically distinct clades, recognized here as sect. Cylindricaulis and sect. Schnabelia. (4) Traditionally defined Caryopteris is confirmed to be polyphyletic, with several segregate genera. (5) Recircumscribed Caryopteris was found to be monophyletic, but intrageneric relationships were not fully resolved. Synapomorphies of Caryopteris include boat–shaped nutlets that are winged along the edge, fimbriate anterior corolla lobes, and suprareticulate pollen sculpturing. Caryopteris forrestii var. minor was elevated to species rank based on molecular and morphological evidence.
Uncemented short stems in primary total hip arthroplasty
Authors: Loppini Mattia , Grappiolo Guido 
Published: May 2018

Over the last two decades, several conservative femoral prostheses have been designed. The goals of conservative stems include: the spearing of the trochanteric bone stock; a more physiological loading in the proximal femur reducing the risk of stress shielding; and to avoid a long stem into the diaphysis preventing impingement with the femoral cortex and thigh pain. All stems designed to be less invasive than conventional uncemented stems are commonly named ‘short stems’. However, this term is misleading because it refers to a heterogeneous group of stems deeply different in terms of design, biomechanics and bearing. In the short-term follow-up, all conservative stems provided excellent survivorship. However, variable rates of complications were reported, including stem malalignment, incorrect stem sizing and intra-operative fracture. Radiostereometric analysis (RSA) studies demonstrated that some conservative stems were affected by an early slight migration and rotation within the first months after surgery, followed by a secondary stable fixation. Dual-energy x-ray absorptiometry (DEXA) studies demonstrated an implant-specific pattern of bone remodelling. Although the vast majority of stems demonstrated a good osseointegration, some prostheses transferred loads particularly to the lateral and distal-medial regions, favouring proximal stress shielding and bone atrophy in the great trochanter and calcar regions. Cite this article: EFORT Open Rev 2018;3:149-159. DOI: 10.1302/2058-5241.3.170052
On local integration of Lie brackets
Authors: Cabrera Alejandro , Mărcuţ Ioan , Salazar María Amelia 
Published: May 2018

Abstract
We give a direct, explicit and self-contained construction of a local Lie groupoid integrating a given Lie algebroid which only depends on the choice of a spray vector field lifting the underlying anchor map. This construction leads to a complete account of local Lie theory and, in particular, to a finite-dimensional proof of the fact that the category of germs of local Lie groupoids is equivalent to that of Lie algebroids.
On mixed norm Bergman–Orlicz–Morrey spaces
Authors: Karapetyants Alexey N. , Samko Stefan G. 
Published: May 2018

Abstract
Following the ideas of our previous research, in this paper we continue the study of new Bergman-type spaces on the unit disc with mixed norm in terms of Fourier coefficients. Here we deal with the case where the sequence of norms of Fourier coefficients in the Orlicz–Morrey space in radial variable belongs to

l
q

{l^{q}}

. We study the boundedness of the Bergman projection and provide a description of functions in these spaces via the behavior of their Taylor coefficients.
Microwave-assisted synthesis and biological evaluation of thiazole-substituted dibenzofurans
Authors: Kumar Baba N.H. , Ashok D. , Rao Boddu Ananda , Madderla Sarasija , Murthy N.Y.S. 
Published: May 2018

Abstract
New thiazole-substituted dibenzofurans 7a–j were synthesized from dibenzofuran derivatives 5a–b and substituted thiosemicarbazones 6a–h under conventional and microwave irradiation conditions. The structures of all products were established on the basis of analytical and spectral data. The synthesized compounds were evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative strains. Compounds 7b, 7d and 7h are active against Bacillus subtilis (+ve), and compound 7i displays good activity against Pseudomonas aeruginosa (-ve) strain. Compounds 7a–j were also evaluated for their in vitro antimycobacterial activity, and compound 7b shows antimycobacterial activity against Mycobacterium bovis strain.
A non-smooth and non-convex regularization method for limited-angle CT image reconstruction
Authors: Zhang Lingli , Zeng Li , Wang Chengxiang , Guo Yumeng 
Published: May 2018

Abstract
Restricted by the practical applications and radiation exposure of computed tomography (CT), the obtained projection data is usually incomplete, which may lead to a limited-angle reconstruction problem. Whereas reconstructing an object from limited-angle projection views is a challenging and ill-posed inverse problem. Fortunately, the regularization methods offer an effective way to deal with that. Recently, several researchers are absorbed in

ℓ
1

{\ell_{1}}

regularization to address such problem, but it has some problems for suppressing the limited-angle slope artifacts around edges due to incomplete projection data. In this paper, in order to surmount the ill-posedness, a non-smooth and non-convex method that is based on

ℓ
0

{\ell_{0}}

and

ℓ
1

{\ell_{1}}

regularization is presented to better deal with the limited-angle problem. Firstly, the splitting technique is utilized to deal with the presented approach called LWPC-ST-IHT. Afterwards, some propositions and convergence analysis of the presented approach are established. Numerical implementations show that our approach is more capable of suppressing the slope artifacts compared with the classical and state of the art iterative reconstruction algorithms.
Language policy and practice in multilingual production workplaces
Authors: Lønsmann Dorte , Kraft Kamilla 
Published: May 2018

AbstractTransnational mobility results in a diversification of languages and cultures in the workplace. A common means of managing this diversity is to introduce language policies that often privilege English or the locally dominant language(s). In contrast, managing their everyday working lives may require employees to draw on a range of multilingual and non-verbal resources. Such tensions between policy and practice in multilingual workplaces may impact structures and processes of inequality and power in the workplace. By looking at two sites within logistics and construction, this article offers a critical look at multilingual policies and practices and their consequences for speakers within the workplace. The article investigates how language is conceptualised in language policies and enacted in language practice. From this point of departure we discuss how the tensions between policies and practices impact on the daily working life and professional opportunities of the workers. Our findings suggest that even though multilingual practices are crucial for the flow of everyday work interactions on the floor, the language requirements within the workplace mirror the repertoires and practices of high-status employees, and therefore their competence is valued more highly than the more multilingual repertoires of their subordinates. A consequence of this unequal valorisation of the different linguistic repertoires is the maintenance of existing hierarchies in the workplace and the creation of new ones.
Tax or social security contribution, a world of difference?
Authors: Weerepas Marjon 
Published: May 2018

Abstract
Cross-border employees and self-employed workers are confronted with the regulations of at least two states when it comes to taxation and social security. Without delving into the specifics of national regulations, this article examines the applicable rules concerning the levy of taxes and social security contributions in the context of cross-border employment. Regulations aimed at avoiding double taxation are different from those aimed at avoiding the double payment of social security contributions. Because social security in the Member States can be financed in different ways, the levying of so-called economic double taxation is possible. This is true in particular where states use a large part of the tax revenues to finance their social security system. Cross-border workers that are required to pay taxes in these states and also pay social security contributions in another state can feel that they are paying double social security contributions. This contributes to a sense of injustice and is undesirable. The conclusion is that possible double economic contributions must be studied in a broader European context. First, the problem must be identified and then solutions formulated in order to prevent double levying.
Organizational Culture and Scale Development: Methodological Challenges and Future Directions
Authors: Bavik Ali , Duncan Tara 
Published: May 2018

Abstract
Defining and measuring organizational culture (OC) is of paramount importance to organizations because a strong culture could potentially increase service quality and yield sustainable competitive advantages. However, such process could be challenging to managers because the scope of OC has been defined differently across disciplines and industries, which has led to the development of various scales for measuring OC. In addition, previously developed OC scales may also not be fully applicable in the hospitality and tourism context. Therefore, by highlighting the key factors affecting the business environment and the unique characteristics of hospitality industry, this paper aims to align the scope of OC closely with the industry and to put forth the need for a new OC scale that accurately responds to the context of the hospitality industry.
Autoregressive Integrated Moving Average Model to Predict Graduate Unemployment in Indonesia
Authors: Mahmudah Umi 
Published: May 2018

Abstract
Nowadays it is getting harder for higher education graduates in finding a decent job. This study aims to predict the graduate unemployment in Indonesia by using autoregressive integrated moving average (ARIMA) model. A time series data of the graduate unemployment from 2005 to 2016 is analyzed. The results suggest that ARIMA (1,2,0) is the best model for forecasting analysis, where there is a tendency of increasing number for the next ten periods. Furthermore, the average of point forecast for the next 10 periods is about 1,266,179 while its minimum value is 1,012,861 the maximum values is 1,523,156. Overall, ARIMA (1,2,0) provides an adequate forecasting model so that there is no potential for improvement.
Der Wandel des italienischen Sozialstaats in Zeiten politischer Umbrüche
Authors: Kramer Nicole 
Published: May 2018

Riassunto:
La storia dello Stato sociale italiano affonda le sue radici nel XIX secolo e comprende un periodo di radicali cambiamenti politici. Introducendo la sezione tematica „Le molte facce dello Stato sociale. Prospettive sulla storia della protezione sociale in Italia tra dittatura e democrazia“, il contributo offre una panoramica della ricerca e discute, in particolare, i risultati a cui sono giunti nuovi studi. A partire dai primordi delle assicurazioni sociali nel nuovo Regno d’Italia si seguono le fasi dell’ampliamento e della trasformazione dei sistemi di sicurezza sociale con particolare riguardo alle innovazioni realizzate durante la guerra e nel dopoguerra, nonché al quadro ideologico e alle idee guida su cui si basano. Da ciò emerge che la forma dello Stato sociale italiano è stata influenzata sia dalla monarchia che dalla dittatura e la democrazia. Si discute in quale misura i passaggi da un regime all’altro, come pure le conseguenze prodotte dalla guerra, abbiano innescato dinamiche trasformative.
Das faschistische System der sozialen Vorsorge im Spannungsverhältnis zwischen autoritären Maßnahmen und sozialer Integration
Authors: Giorgi Chiara 
Published: May 2018

Riassunto:
Il saggio ripercorre alcuni passaggi fondamentali inerenti lo sviluppo dello Stato sociale italiano durante gli anni del fascismo, inquadrandoli tanto nel dibattito storiografico più recente, quanto nell’ambito di alcune issues nazionali e internazionali. In questo senso le politiche assicurative e previdenziali fasciste verranno prese in esame sia nel contesto più complessivo della crescita delle politiche sociali degli anni Trenta (europee e non solo), sia in riferimento alle principali istituzioni italiane (in primis l’INFPS, l’Istituto nazionale fascista di previdenza sociale). In particolare il testo è teso a mettere in evidenza la centralità dell’esperienza fascista rispetto al consolidamento storico del welfare nazionale, i cui connotati originali si collocano proprio negli anni di costruzione del regime. Il periodo fascista pose infatti le basi di quel sistema cosiddetto „particolaristico-clientelare“ che si sarebbe poi sviluppato e intensificato nel secondo dopoguerra e che rappresenta, secondo varie voci storiografiche, il tratto più distintivo della vicenda italiana. I dati conclusivi che emergono sono che, in relazione ad una media europea, l’Italia riuscì a recuperare sotto il profilo quantitativo, aumentando la spesa per la sicurezza sociale e il grado di copertura assicurativa. Tuttavia, la cifra impressa dal regime al welfare nazionale ne avrebbe segnato gli sviluppi successivi, facendo emergere la centralità dell’esperienza fascista in ordine alle caratteristiche (e alle dimensioni) di quest’ultimo. Secondariamente, la riorganizzazione avvenuta sotto il fascismo dell’ambito assicurativo e previdenziale – in ordine all’estensione delle forme di tutela, del numero degli assistiti e soprattutto in materia di sistematizzazione – riguardò per lo più gli aspetti gestionali. Invariata restò una politica di differenziazione delle spettanze che anzi venne accentuata e utilizzata dal regime ai fini del controllo sociale. Il fascismo infatti moltiplicò forme e regimi assicurativi diversi e differenziati, nella misura, nella qualità e nel tempo. La ricostruzione delle vicende previdenziali italiane nel periodo tra le due guerre è così inserita in un più ampio contesto sia geografico (europeo e d’Oltreoceano), sia economico, politico e sociale.
La santa di Casa: Benedetto XIV e la beata Imelda Lambertini
Authors: Fattori Maria Teresa 
Published: May 2018

Zusammenfassung:
Papst Benedikt XIV. leitete keinen auf die Kanonisierung zielenden Seligsprechungsprozess Imelda Lambertinis ein, obgleich er als Prälat die junge, 1333 verstorbene Nonne schätzte. Die Überlieferung weist in diesem Fall viele Lücken und kaum zuverlässiges Quellenmaterial auf, während die Literatur des 18. Jh. aus dem Umfeld Muratoris dem Seligenkult Imeldas eher abträglich war. Der Beitrag analysiert in drei Schritten die Gründe für die Weigerungshaltung Benedikts XIV. (1675–1758). Zunächst werden die Fakten und Dokumente zusammengestellt, über die sich der Papst die entsprechenden Informationen zu verschaffen versuchte. In einem zweiten Schritt wird die Entwicklung des Imelda-Kultes im 17. und 18. Jh. skizziert, wobei der potentiell heilige Wesenszug dieser Figur aufscheint und das Thema der eucharistischen Devotion, die für ihr Leben kennzeichnend ist, in den Zusammenhang der Debatten über die Eucharistie eingeordnet wird. Schließlich sollen die Zweifel erörtert werden, mit denen die Kultur des 18. Jh. auf die hagiographische Tradition blickte; vor dem Hintergrund des innigen, aber auch höchst kritischen Verhältnisses zwischen dem Bologneser Papst einerseits und seiner Familie bzw. seiner Geburtsstadt andererseits lassen sich auf diese Weise die Beweggründe herausarbeiten, die ihm nahelegten, auf eine Selig- und Heiligsprechung zu verzichten.
Das epistolarische Werk von Ferdinand Gregorovius. Eine Bestandsaufnahme
Authors: Steinsiek Angela 
Published: May 2018

Riassunto:
Quello di Ferdinand Gregorovius è uno dei più importanti carteggi del XIX secolo. Nonostante gli sforzi dell’autore di sottrarre questa parte delle sue carte al pubblico, si sono conservate diverse migliaia di lettere che, accanto alla sua opera complessiva, rivestono un valore straordinario anche dal punto di vista letterario. Indispensabili sono le lettere per ricostruire la genesi dei suoi lavori, per comprenderne la qualità nella dialettica tra letteratura e scienza, per identificare i suoi scritti anonimi. Le sue corrispondenze con studiosi, nobili, politici, scrittori, artisti ed editori rappresentano nell’insieme un documento unico della storia politica e sociale, culturale e delle scienze nel XIX secolo e permettono di farsi un’idea concreta sulle vaste reti di contatto transnazionali non solo epistolari, ma anche personali, e sulle condizioni di lavoro di uno storico che svolgeva le sue attività liberamente e in modo indipendente. Le sue corrispondenze, coprendo diversi decenni, mettono infine in luce i rapidi sviluppi che nella loro interazione contrassegnarono la storia italiana e tedesca dell’epoca.
Hat Papstgeschichte Zukunft?
Authors: Reinhard Wolfgang 
Published: May 2018

Riassunto:
Sembra che almeno in Germania si stia esaurendo l’attività editoriale che riguarda i rapporti mandati dai nunzi alla segreteria di Stato. Nella digitalizzazione delle fonti si può ravvisare una valida alternativa compensatoria, tanto più che essa consentirebbe di creare una vasta banca dati che, raccogliendo i dati di tutte le persone e tutti gli uffici della curia, offrirebbe un’ottima base per ulteriori ricerche. In ogni caso è possibile raccordare la storia dei papi al nuovo approccio decostruttivista della storia politica e culturale, se si pone al centro dell’attenzione il papato nella sua qualità di singolare potenza culturale che coltiva una sua singolare cultura del potere. Decisiva è la constatazione che la chiesa papale non solo funse da modello per la formazione degli Stati europei, ma sarebbe diventata Stato essa stessa. In questo senso sarebbero auspicabili studi a lungo termine sul personale e sulle istituzioni. Accanto a questa storia materiale sarebbero utili sia l’indagine della devozione personale dei papi, e in particolare del culto mariano, che l’esplorazione del culto del papa e di altre pratiche premoderne, ma tuttora vive, nei credenti.