bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of time series using periodic gamma autoregressive models
Authors: Leite de Almeida Duca Victor Eduardo , Castro Souza Reinaldo , Costa Ferreira Pedro Guilherme , Cyrino Oliveira Fernando Luiz 
Published: September 2018

AbstractPeriodic autoregressive models are frequently used to model hydrologic series. In the literature, annual streamflow series are approximated by normal distribution. However, for short periods (daily, weekly, monthly) this is no longer the case, particularly due to the data skewness. A new class of first‐order model was, therefore, studied in an attempt to overcome this problem. The model has an autoregressive structure and can be additive, multiplicative, or hybrid, but with gamma marginal distribution. Furthermore, the classical model assumes that the method of moments is effective for parameters estimation. For the first time, this paper undertakes a complete analysis of the hybrid model for this context and the novelty lies in the parameter estimation via maximization of the likelihood function. For an application in the Brazilian case, the additive model proved to be more effective than previously reported and the method allows high orders and skewed distributions.
Role of interfaces in damage process of irradiated lithium aluminate nanocrystals
Authors: Setyawan Wahyu , Senor David J. , Devanathan Ram 
Published: September 2018

AbstractMolecular dynamics simulations were performed to understand the differences in the response of single crystal and nanocrystalline γ‐LiAlO2 to energy deposition by 10 keV Li recoils. The simulations are performed at 573 K and focus on the damage production in the absence of thermal annealing. The grain boundaries in the nanocrystals are found to be amorphous. Analyses of the fate of the beam ions show that the amorphous grain boundaries and differently oriented nanograins increase the number of backscattered ions and decrease the number of transmitted ions. Damaged regions protruding from the grain boundaries provide a direct evidence of the role of the grain boundaries as scattering centers in collision cascades. The simulations show that the defect density produced in the nanocrystals is about twice that in the single crystals. In both samples, Li defects account for 70% of the defects, demonstrating that LiO4 tetrahedra are much more susceptible to damage than AlO4 tetrahedra. Furthermore, Li defects occur preferentially near grain boundaries. Diffusion simulations confirm the limited thermal diffusion of defects at 573 K, effectively separating the damage production from thermal annealing in the irradiation simulations. Nevertheless, the mean square displacements of grain‐boundary defects are found to be larger than lattice defects and surface defects.
Complex impedance spectroscopy of perovskite microwave dielectric ceramics with high dielectric constant
Authors: Wang Zixing , Yuan Changlai , Zhu Baohua , Feng Qin , Liu Fei , Xu Jiwen , Zhou Changrong , Chen Guohua 
Published: September 2018

AbstractThe AC impedance of SrTiO3, Ca0.9Sr0.1TiO3, Ca0.7Sm0.2TiO3, and Ca0.7Sm0.3Ti0.7Al0.3O3 microwave dielectric ceramics with perovskite structures has been analyzed. The impedance spectroscopy results reveal the electrical properties of this series of samples vary significantly with the ceramic microstructure and electrical homogeneity. The εr values of grains for SrTiO3 and Ca0.9Sr0.1TiO3 ceramics are 193.8 and 138.1, respectively, confirming that dielectric response of the high‐εr microwave ceramics is contributed to the grains, at microwave frequencies. Impedance spectroscopy of Ca0.7Sm0.2TiO3 ceramic illustrates that electrical heterogeneous microstructures include interior grains and grain shells. The secondary phase existing in Ca0.7Sm0.2TiO3 ceramic causes deviation in bulk permittivity, resulting in a higher εr ~ 148 of grains than εr ~ 112 of bulk permittivity, measured at microwave frequencies. Grain and grain‐boundary impedance of Ca0.7Sm0.3Ti0.7Al0.3O3 ceramic cannot be separated completely. The permittivities of grains and grain boundaries in Ca0.7Sm0.3Ti0.7Al0.3O3 ceramic are εg ~ 17.8 and εgb ~ 20.8, and the combination of them is close to εr ~ 40 at microwave frequencies. The LogI−LogU curves of the ceramic system indicate that the conducting mechanism of grains and grain boundaries follows ohmic behavior.
Job satisfaction, job stress and nurses’ turnover intentions: The moderating roles of on‐the‐job and off‐the‐job embeddedness
Authors: Fasbender Ulrike , Van der Heijden Beatrice I. J. M. , Grimshaw Sophie 
Published: September 2018

AbstractAimUsing an interactionist perspective to test on‐the‐job embeddedness and off‐the‐job embeddedness as possible moderators for the predictive effects of job satisfaction and job stress on nurses’ turnover intentions.BackgroundAs turnover worsens nurse shortages across the globe, researchers needs to find ways to work out and reduce nurses’ turnover intentions. By exploring contributory factors, namely on‐the‐job and off‐the‐job embeddedness as two distinctive forms that both act as moderators, we add to the literature on effective nurse retention and highlight that incorporating off‐the‐job factors can provide a more realistic understanding of why people consider leaving their organization.DesignSurvey of 361 nurses of the United Kingdom's (UK's) National Health Service, in 2016.MethodWe conducted hierarchical multiple regression and simple slope analyses.ResultsJob satisfaction was negatively associated with turnover intentions, and this negative relationship was stronger when off‐the‐job embeddedness was high (vs. low). Job stress was positively related to turnover intentions, yet high (vs. low) off‐the‐job embeddedness buffered this relationship. In contrast, when on‐the‐job embeddedness was high (vs. low), the relationship between job stress and turnover intentions were even stronger.ConclusionResults showed that using an interactionist perspective is useful in predicting nurse turnover. Nursing management should be made aware of the importance of being embedded off‐the‐job to prevent nurse turnover. This paper issues guidelines to form a more comprehensive staff retention programme for the healthcare sector.
Marital functioning and treatment outcome in couples undergoing assisted reproduction
Authors: Martínez‐Pampliega Ana , Cormenzana Susana , Martín Sagrario , Navarro Lucía 
Published: September 2018

AbstractAimTo investigate the relationship between the quality of marital functioning and communication, individual psychological symptomatology, and pregnancy achievement in couples undergoing assisted reproduction.BackgroundThe results concerning marital functioning and the feasibility of pregnancy yield contradictory outcomes and the quality of the relationship of the couple undergoing assisted reproduction has not been analysed from systemic models. Our hypothesis is that when undergoing assisted reproduction treatment (ART), the couple's functioning and communication will be related to the pregnancy rate.DesignThis study employs a cross‐sectional design with couples receiving ART.MethodsSpanish heterosexual couples (N = 185) completed the self‐report instruments. The data were collected from 2010 ‐ 2015. All the couples completed at least one treatment process, or at least 1 year had gone by since beginning the treatment.ResultsThe association between couple relationship quality and the individual psychological symptomatology experienced during the assisted reproduction process was confirmed in men and women. Although both members of the couple experienced an increase of symptomatology, only men's symptomatology was statistically significantly linked to pregnancy achievement.ConclusionIt is necessary to support the couple from the assisted reproduction centres, promoting cohesion, flexibility, and communication in the relationship. The intervention process should also be understood from a systemic perspective; that is, considering dyadic transactions as a systemic unit. Two aspects seem to be especially relevant for clinical nurses in ART: (a) the man's role is crucial for treatment success; (b) the woman's communication is crucial to the process.
Plectin protects podocytes from adriamycin‐induced apoptosis and F‐actin cytoskeletal disruption through the integrin α6β4/FAK/p38 MAPK pathway
Authors: Ni Yongliang , Wang Xin , Yin Xiaoxuan , Li Yan , Liu Xigao , Wang Haixin , Liu Xiangjv , Zhang Jun , Gao Haiqing , Shi Benkang , Zhao Shaohua 
Published: September 2018

AbstractPodocyte injury is an early pathological change characteristic of various glomerular diseases, and apoptosis and F‐actin cytoskeletal disruption are typical features of podocyte injury. In this study, we found that adriamycin (ADR) treatment resulted in typical podocyte injury and repressed plectin expression. Restoring plectin expression protected against ADR‐induced podocyte injury whereas siRNA‐mediated plectin silencing produced similar effects as ADR‐induced podocyte injury, suggesting that plectin plays a key role in preventing podocyte injury. Further analysis showed that plectin repression induced significant integrin α6β4, focal adhesion kinase (FAK) and p38 MAPK phosphorylation. Mutating Y1494, a key tyrosine residue in the integrin β4 subunit, blocked FAK and p38 phosphorylation, thereby alleviating podocyte injury. Inhibitor studies demonstrated that FAK Y397 phosphorylation promoted p38 activation, resulting in podocyte apoptosis and F‐actin cytoskeletal disruption. In vivo studies showed that administration of ADR to rats resulted in significantly increased 24‐hour urine protein levels along with decreased plectin expression and activated integrin α6β4, FAK, and p38. Taken together, these findings indicated that plectin protects podocytes from ADR‐induced apoptosis and F‐actin cytoskeletal disruption by inhibiting integrin α6β4/FAK/p38 pathway activation and that plectin may be a therapeutic target for podocyte injury‐related glomerular diseases.
An exceptional uterine inversion in a virgo patient affected by submucosal leiomyoma: Case report and review of the literature
Authors: Della Corte Luigi , Giampaolino Pierluigi , Fabozzi Annamaria , Di Spiezio Sardo Attilio , Bifulco Giuseppe 
Published: September 2018

AbstractInversion of the uterus is quite a rare obstetric (puerperal) or gynecological (non‐puerperal) condition. Non‐puerperal type may be benign or malign mass induced or idiopathic. To the best of our knowledge, this is the first case with a large review of literature of uterine inversion in a patient without sexual experience. We report the case of a 52‐year‐old, unmarried virgo woman, affected by schizophrenia, was referred to our emergency room for evidence of a mass outside of the vaginal introitus, combined with vaginal bleeding and abdominal pain. The patient underwent vaginal myoma resection and abdominal hysterectomy with bilateral adnexectomy. The diagnosis of uterine inversion was confirmed during operation. Diagnosis of uterine inversion is often not easy and imaging studies might be helpful. Despite the rarity, uterine non‐puerperal inversion is possible: for this reason, it is necessary to perform appropriate, conservative treatment, especially in women affected by benign myomas and with a desire for pregnancy.
Improvement of LVEF in patients with HFrEF with coronary heart disease after revascularization—A real‐world study
Authors: Peng Ding , Liu Jing‐hua 
Published: September 2018

ObjectiveThis study aimed to explore the predictive factors for left ventricular ejection fraction (LVEF) improvement after revascularization.MethodsThis real‐world study examined 993 patients with ischemic HFrEF who had received revascularization (PCI or CABG), had survived at least 90 days and had undergone an echocardiography review. Based on the change in the LVEF, we divided the patients into two groups.ResultWe obtained 454 patients with ≥10% improvement and 539 with <10% improvement or deterioration. By Cox regression analysis, we obtained five independent factors for LVEF improvement, including female (P = 0.018, OR 0.726, 95% CI 0.557‐0.947), prior MI (P = 0.000, OR 0.590, 95% CI 0.476‐0.732), LVEF (P = 0.008, OR 0.967, 95% CI 0.943‐0.991), digoxin (P = 0.027, OR 0.708, 95% CI 0.521‐0.961), loop diuretic (P = 0.000, OR 1.515, 95% CI 1.208‐1.901), and triple‐vessel disease (P = 0.000, OR 1.462, 95% CI 1.192‐1.792). By multivariate generalized estimation, we obtained seven factors associated with the degree of improvement, namely, low LVEF, short LVESD, short LVEDD, no prior MI, no hyperuricemia, clopidogrel use and triple‐vessel disease.ConclusionsThe method of revascularization (PCI vs CABG) had no effect on LVEF improvement. Patients with severely impaired baseline LVEFs, triple‐vessel disease, or no history of MI tended to exhibit marked LVEF improvement (≥10%) after revascularization. In addition, LVESD, LVEDD, hyperuricemia, clopidogrel use and loop diuretic affected the degree of improvement.
Bioinformatics analysis of microarray profiling identifies the mechanism of focal adhesion kinase signalling pathway in proliferation and apoptosis of breast cancer cells modulated by green tea polyphenol epigallocatechin 3-gallate
Authors: Luo Xiao , Guo Lihua , Zhang Lirong , Hu Yu , Shang Dongmei , Ji Degang 
Published: September 2018

Abstract

Objectives
This study aimed to investigate potential gene and signal pathway associated with tumour progression.

Methods
Related microarray data set of breast cancer was obtained from Gene Expression Omnibus database, and differential-expressed genes (DEGs) between two control samples and two treated samples were analysed using statistical software R. We collected 50 epigallocatechin-3-gallate(EGCG)-related genes and 119 breast cancer-related genes to create a knowledge base for following pathway analysis.

Key findings
A total of 502 mRNAs were identified as DEGs based on microarray analysis. Upregulated DEGs mainly enriched in nuclear nucleosome, cell adhesion, DNA packaging complex, Wnt-activated receptor activity, etc., while the downregulated DEGs significantly enriched in ncRNA processing, mitotic nuclear division, DNA helicase activity, etc. DEGs mostly enriched in gap junction, cell cycle, oxidative phosphorylation, focal adhesion, etc. EGCG suppressed FAK signalling pathway. Furthermore, EGCG could inhibit breast cancer cell proliferation and promote apoptosis by modulating CCND1.

Conclusions
Epigallocatechin 3-gallate might exert influence on breast cancer progression through inhibiting focal adhesion kinase (FAK) signalling pathway.
Synergistic interactions between konjac‐mannan and xanthan/tragacanth gums in tomato ketchup: Physical, rheological, and textural properties
Authors: Mirzaei Massume , Alimi Mazdak , Shokoohi Shirin , Golchoobi Laleh 
Published: September 2018

AbstractIn this research, simultaneous contribution of konjac‐mannan (0.3%), xanthan (0.3%), and tragacanth (0.3%) gums in tomato ketchup was investigated comparing the physicochemical, rheological, texture, and sensory properties with the control sample containing 0.3% xanthan gum. Samples selected through viscosity and syneresis evaluation of the nine prepared samples were analyzed by color, flow behavior, frequency sweep, particle size, texture, and sensory experiments. Results indicated that increasing xanthan concentration did not have any significant effect on the apparent viscosity while considerable improvement was observed in the physical stability of ketchups containing konjac‐mannan/xanthan ascribed to smaller particles with larger contact surfaces encouraging gel network formation. Highest a* and a*/b* was observed for konjac‐mannan/xanthan (0.075%/0.225%) in which formation of hydrated gel granules of gums intensifies light diffraction due to the decreased particle size. This synergistically formed viscous three‐dimensional gel network is responsible for the highest cohesiveness and gumminess of the same sample between the ketchup formulations containing two gums. Organoleptic properties of ketchup samples containing konjac‐mannan/xanthan showed no significant difference with the control sample.Practical applicationsDevelopment of modern food technologies along with the lifestyle changes over the past few decades and grown public awareness of the relevance between health and nutrition have considerably increased the consumption of ready meals containing low‐fat and fiber‐rich functional condiments. Ketchup is a popular sauce thickened with tomato pulp powder, potato or corn starch, modified starch, and severally available hydrocolloids such as carboxymethyl cellulose, xanthan, guar, and locust bean gum. In this research work, mixtures of konjac‐mannan and xanthan/tragacanth hydrocolloids are used to produce new ketchups with improved physical and rheological properties and lower prices.
Early modern women in the English courts of law
Authors: Fikkers Lotte 
Published: September 2018

AbstractThe recent publication of The Oxford handbook of English law and literature, 1500–1700 (2017) has put the field of early modern law and literature firmly on the map. Despite the growing attention to the importance of these intersecting fields in early modern England, however, working with legal records is still a daunting task for many literary scholars. The early modern legal system with its various, sometimes competing jurisdictions and numerous law courts presents, to many scholars, a difficulty to navigate maze. Particularly for those working on early modern women's literature, and women's studies more generally, this is unfortunate: The legal archives offer a wealth of records in manuscript form pertaining to the lives and narratives of early modern women from all ranks of society, including the poor and the illiterate. This article aims to offer a comprehensive overview of the early modern law courts and their records, outlining the way the law restrained women as well as the possibilities it offered them, alongside the ways women were able to navigate these restrictions and opportunities. In doing so, this article provides tools for scholars working with early modern legal records for the first time.
Trimethoprim‐sulfamethoxazole‐induced drug reaction with eosinophilia and systemic symptoms in a child with congenital renal disease
Authors: Maarouf Melody , Wickenheiser Marilyn , Krase Jeffrey M. , Wolter Sierra , Shi Vivian Y. 
Published: September 2018

AbstractWe present a special case of an 8‐year‐old girl diagnosed with severe drug reaction with eosinophilia and systemic symptoms due to trimethoprim‐sulfamethoxazole for urinary tract infection prophylaxis for congenital vesicoureteral reflux. The patient is believed to have developed drug reaction with eosinophilia and systemic symptoms because of her underlying renal disease.
Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature
Authors: Stefanko Nicole S. , Drolet Beth A. 
Published: September 2018

AbstractSubcutaneous fat necrosis of the newborn is an uncommon disorder, and although usually benign, associated hypercalcemia can lead to complications such as failure to thrive and renal failure. Many sources suggest screening for hypercalcemia for 6 months following resolution of skin lesions, but little data are available to support this recommendation. This study examines existing published literature to better guide practitioners regarding screening evaluations of asymptomatic patients with subcutaneous fat necrosis. A systematic review of the literature was conducted using a PubMed English literature search. Data from case reports and case series were collected regarding the presence of hypercalcemia and associated complications, birth history, and age of onset/resolution of skin lesions and laboratory abnormalities. Approximately half (51%) of infants reported had hypercalcemia. Most (77%) developed detectable hypercalcemia within 30 days of skin lesion onset, and 95% developed detectable hypercalcemia within 60 days of skin lesion onset. Hypercalcemia was detected in only 4% of patients > 70 days following onset of skin lesions. Seventy‐six percent had resolution of hypercalcemia within 4 weeks of detection. Hypercalcemia was more prevalent in full‐term vs pre‐term infants (P‐value = 0.054), and higher birthweight was significantly associated with an increased risk of developing hypercalcemia (P‐value = 0.022). Although gestational age trended toward significance, the only statistically significant clinical feature predicting the development of hypercalcemia was higher birthweight. Current recommendations for laboratory monitoring are not evidence‐based, and this study provides interim data to guide practitioners until prospective, randomized controlled trials are conducted.
FIRST‐ORDER LOGICAL VALIDITY AND THE HILBERT‐BERNAYS THEOREM
Authors: Ebbs Gary , Goldfarb Warren 
Published: September 2018

AbstractWhat we call the Hilbert‐Bernays (HB) Theorem establishes that for any satisfiable first‐order quantificational schemaS, there are expressions of elementary arithmetic that yield a true sentence of arithmetic when they are substituted for the predicate letters inS. Our goals here are, first, to explain and defend W. V. Quine's claim that the HB theorem licenses us to define the first‐order logical validity of a schema in terms of predicate substitution; second, to clarify the theorem by sketching an accessible and illuminating new proof of it; and, third, to explain how Quine's substitutional definition of logical notions can be modified and extended in ways that make it more attractive to contemporary logicians.
Retracted:Leishmania infection activates host mTOR for its survival by M2 macrophage polarization
Authors: Kumar Ajay , Das Sushmita , Mandal Abhishek , Verma Sudha , Abhishek Kumar , Kumar Ashish , Kumar Vinod , Ghosh Ayan Kumar , Das Pradeep 
Published: September 2018

SummaryMammalian target of rapamycin (mTOR) is a central regulator of growth and immunity of host cells. It's involvement in cancer and tuberculosis is well documented but least explored in Leishmania donovani invasion of host cells. Therefore, in the present study, we aimed to investigate the role of mTOR in M2 macrophage polarization for Leishmania survival. We observed that Leishmania infection activated host mTOR pathway characterized by phosphorylation of mTOR, 70S6K and 4‐EBP1. Inhibition of mTOR resulted in decreased parasite load and percent infectivity. Moreover, Leishmania infection triggered cell proliferation as was evidenced by increased expression of cyclin A and p‐RPS6. mTOR activation during Leishmania infection resulted in reduced expression of M1 macrophage markers (eg, ROS, NO, iNOS, NOX‐1, IL‐12, IL‐1β and TNF‐α), and increased expression of M2 macrophage markers (eg, arginase‐1, IL‐10, TGF‐β, CD206 and CD163). Furthermore, we observed that in case of Leishmania infection, mTOR inhibition increased the translocation of NF‐κB to nucleus and deactivation of STAT‐3. Eventually, we observed that inhibition of M2 macrophage polarization reduced Leishmania survival inside macrophages. Therefore, our findings suggest that mTOR plays a crucial role in regulation of M2 macrophage polarization and direct the innate immune homeostasis towards parasite survival inside host.