bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinetic control of tunable multi-state switching in ferroelectric thin films
Authors: Xu R. , Liu S. , Saremi S. , Gao R. , Wang J. J. , Hong Z. , Lu H. , Ghosh A. , Pandya S. , Bonturim E. , Chen Z. H. , Chen L. Q. , Rappe A. M. , Martin L. W. 
Published: March 2019

AbstractDeterministic creation of multiple ferroelectric states with intermediate values of polarization remains challenging due to the inherent bi-stability of ferroelectric switching. Here we show the ability to select any desired intermediate polarization value via control of the switching pathway in (111)-oriented PbZr0.2Ti0.8O3 films. Such switching phenomena are driven by kinetic control of the volume fraction of two geometrically different domain structures which are generated by two distinct switching pathways: one direct, bipolar-like switching and another multi-step switching process with the formation of a thermodynamically-stable intermediate twinning structure. Such control of switching pathways is enabled by the competition between elastic and electrostatic energies which favors different types of ferroelastic switching that can occur. Overall, our work demonstrates an alternative approach that transcends the inherent bi-stability of ferroelectrics to create non-volatile, deterministic, and repeatedly obtainable multi-state polarization without compromising other important properties, and holds promise for non-volatile multi-state functional applications.
Publisher Correction: Room temperature CO2 reduction to solid carbon species on liquid metals featuring atomically thin ceria interfaces
Authors: Esrafilzadeh Dorna , Zavabeti Ali , Jalili Rouhollah , Atkin Paul , Choi Jaecheol , Carey Benjamin J. , Brkljača Robert , O’Mullane Anthony P. , Dickey Michael D. , Officer David L. , MacFarlane Douglas R. , Daeneke Torben , Kalantar-Zadeh Kourosh 
Published: March 2019

The original version of this Article contained errors in the author affiliations. Affiliation 1 incorrectly read ‘School of Chemical Engineering, University of New South Wales (UNSW), Sydney, NSW 2031, Australia’ and affiliation 4 incorrectly read ‘School of Engineering, RMIT University, Melbourne, VIC 3001, Australia.’ This has now been corrected in both the PDF and HTML versions of the Article.
Cascade anchoring strategy for general mass production of high-loading single-atomic metal-nitrogen catalysts
Authors: Zhao Lu , Zhang Yun , Huang Lin-Bo , Liu Xiao-Zhi , Zhang Qing-Hua , He Chao , Wu Ze-Yuan , Zhang Lin-Juan , Wu Jinpeng , Yang Wanli , Gu Lin , Hu Jin-Song , Wan Li-Jun 
Published: March 2019

AbstractAlthough single-atomically dispersed metal-Nx on carbon support (M-NC) has great potential in heterogeneous catalysis, the scalable synthesis of such single-atom catalysts (SACs) with high-loading metal-Nx is greatly challenging since the loading and single-atomic dispersion have to be balanced at high temperature for forming metal-Nx. Herein, we develop a general cascade anchoring strategy for the mass production of a series of M-NC SACs with a metal loading up to 12.1 wt%. Systematic investigation reveals that the chelation of metal ions, physical isolation of chelate complex upon high loading, and the binding with N-species at elevated temperature are essential to achieving high-loading M-NC SACs. As a demonstration, high-loading Fe-NC SAC shows superior electrocatalytic performance for O2 reduction and Ni-NC SAC exhibits high electrocatalytic activity for CO2 reduction. The strategy paves a universal way to produce stable M-NC SAC with high-density metal-Nx sites for diverse high-performance applications.
Colonization of the human gut by bovine bacteria present in Parmesan cheese
Authors: Milani Christian , Duranti Sabrina , Napoli Stefania , Alessandri Giulia , Mancabelli Leonardo , Anzalone Rosaria , Longhi Giulia , Viappiani Alice , Mangifesta Marta , Lugli Gabriele Andrea , Bernasconi Sergio , Ossiprandi Maria Cristina , van Sinderen Douwe , Ventura Marco , Turroni Francesca 
Published: March 2019

AbstractThe abilities of certain microorganisms to be transferred across the food production chain, persist in the final product and, potentially, colonize the human gut are poorly understood. Here, we provide strain-level evidence supporting that dairy cattle-associated bacteria can be transferred to the human gut via consumption of Parmesan cheese. We characterize the microbial communities in samples taken from five different locations across the Parmesan cheese production chain, confirming that the final product contains microorganisms derived from cattle gut, milk, and the nearby environment. In addition, we carry out a human pilot study showing that Bifidobacterium mongoliense strains from cheese can transiently colonize the human gut, a process that can be enhanced by cow milk consumption.
Estimating Natural Mortality of Atlantic Bluefin Tuna Using Acoustic Telemetry
Authors: Block Barbara A. , Whitlock Rebecca , Schallert Robert J , Wilson Steve , Stokesbury Michael J. W. , Castleton Mike , Boustany Andre 
Published: March 2019

AbstractAtlantic bluefin tuna (Thunnus thynnus) are highly migratory fish with a contemporary range spanning the North Atlantic Ocean. Bluefin tuna populations have undergone severe decline and the status of the fish within each population remains uncertain. Improved biological knowledge, particularly of natural mortality and rates of mixing of the western (GOM) and eastern (Mediterranean) populations, is key to resolving the current status of the Atlantic bluefin tuna. We evaluated the potential for acoustic tags to yield empirical estimates of mortality and migration rates for long-lived, highly migratory species such as Atlantic bluefin tuna. Bluefin tuna tagged in the Gulf of St. Lawrence (GSL) foraging ground (2009–2016) exhibited high detection rates post release, with 91% crossing receiver lines one year post tagging, 61% detected after year two at large, with detections up to ~1700 days post deployment. Acoustic detections per individual fish ranged from 3 to 4759 receptions. A spatially-structured Bayesian mark recapture model was applied to the acoustic detection data for Atlantic bluefin tuna electronically tagged in the GSL to estimate the rate of instantaneous annual natural mortality. We report a median estimate of 0.10 yr−1 for this experiment. Our results demonstrate that acoustic tags can provide vital fisheries independent estimates for life history parameters critical for improving stock assessment models.
A new approach for analyzing an adhesive bacterial protein in the mouse gastrointestinal tract using optical tissue clearing
Authors: Nishiyama Keita , Sugiyama Makoto , Yamada Hiroki , Makino Kyoko , Ishihara Sayaka , Takaki Takashi , Mukai Takao , Okada Nobuhiko 
Published: March 2019

AbstractSeveral bacterial moonlighting proteins act as adhesion factors, which are important for bacterial colonization of the gastrointestinal (GI) tract. However, little is known about the adherence properties of moonlighting proteins in the GI tract. Here, we describe a new approach for visualizing the localization of moonlighting protein-coated fluorescent microbeads in the whole GI tract by using a tissue optical clearing method, using elongation factor Tu (EF-Tu) as an example. As a bacterial cell surface-localized protein mimic, recombinant EF-Tu from Lactobacillus reuteri was immobilized on microbeads. EF-Tu-coating promoted the interaction of the microbeads with a Caco-2 cell monolayer. Next, the microbeads were orally administered to mice. GI whole tissues were cleared in aqueous fructose solutions of increasing concentrations. At 1 h after administration, the microbeads were diffused from the stomach up to the cecum, and after 3 h, they were diffused throughout the intestinal tract. In the lower digestive tract, EF-Tu-beads were significantly more abundant than non-coated control beads, suggesting that EF-Tu plays an important role in the persistence of the microbeads in the GI tract. The new approach will help in evaluating how moonlighting proteins mediate bacterial colonization.
Functional identification of alginate lyase from the brown alga Saccharina japonica
Authors: Inoue Akira , Ojima Takao 
Published: March 2019

AbstractDespite the progress in massive gene analysis of brown algal species, no alginate-degrading enzyme from brown alga has been identified, impeding the understanding of alginate metabolism in brown alga. In the current study, we identified and characterized alginate lyase from Saccharina japonica using a protein-based approach. First, cDNA library was prepared from the S. japonica sporophyte. Expression screening was then performed; the encoding gene was identified and cloned; and the recombinant enzyme was purified and characterized. Alginate lyase production in algal tissues was evaluated by western blotting. The identified alginate lyase, SjAly (359 amino acids, with a predicted N-terminal secretion signal of 27 residues), is encoded by an open reading frame comprising seven exons. Recombinant SjAly exhibited endolytic alginate lyase activity, specifically toward stretches of consecutive β-d-mannuronic acid units. The optimum temperature, pH, and NaCl concentration were 30 °C, pH 8.0, and 100 mM, respectively. SjAly exhibited pronounced activity below 20 °C, the S. japonica growth temperature. SjAly was highly expressed in the blade but not the stipe and rhizoid. The data indicate that S. japonica possesses at least one active alginate lyase. This is the first report of a functional alginate lyase from brown alga, the major natural alginate producer.
The BNT-38: Applying Rasch Analysis to Adapt the Boston Naming Test for Use With English and French Monolinguals and Bilinguals
Authors: Medvedev Oleg N. , Sheppard Christine , Monetta Laura , Taler Vanessa 
Published: March 2019

Purpose

Currently, there is no reliable instrument to measure naming abilities in bilingual speakers of English and French. The Boston Naming Test (BNT;
Kaplan, Goodglass, & Weintraub, 1983
)is a widely used scale for clinical assessments of language function, but it is not suitable to assess bilinguals. Rasch analysis provides a unique and powerful method to establish measurement invariance across language groups that improves reliability of measurement.

Method

Rasch analysis was applied to a sample (
n
= 215) of English or French monolingual and bilingual speakers completing the BNT in either language. Participants included English–French bilinguals (
n
= 83), English monolinguals (
n
= 72), and French monolinguals (
n
= 60).

Results
The best overall Rasch model fit was obtained after the removal of 22 misfitting items, resulting in a 38-item BNT solution (BNT-38), with a modification of 7 items that showed differential item functioning by language factor. To increase the clinical utility of the BNT-38 in French speakers and bilinguals, we generated ordinal-to-interval conversion tables for monolinguals and bilinguals in English and French.

Conclusions
Use of the BNT-38 and the associated conversion tables will allow valid comparisons of naming abilities across bilingual and monolingual English and French speakers of different age groups. Applying these tools increases accuracy in measurement of naming ability and higher diagnostic precision in French and English monolinguals and bilinguals.
Was benötigen LSBTI-Menschen angesichts ihrer Sexual- und Geschlechtsbiografien für eine bessere Gesundheitsversorgung?
Authors: Lampalzer Ute , Behrendt Pia , Dekker Arne , Briken Peer , Nieder Timo O. 
Published: March 2019

Zusammenfassung
Einleitung Studien deuten darauf hin, dass LSBTI-Menschen im Gesundheitssystem häufig mit Herausforderungen und Benachteiligungen konfrontiert sind, die eng mit ihren Sexual- und Geschlechtsbiografien verbunden sind. Für eine deutsche Großstadt liegt hierzu noch keine zielgruppenübergreifende Untersuchung vor.
Forschungsziele Ziel der Studie ist die Beantwortung der Frage, was behandelnde und beratende Fachkräfte über die Sexual- und Geschlechtsbiografien von LSBTI-Menschen wissen sollten und wie sie in ihrer jeweiligen Praxis mit LSBTI-Menschen umgehen sollten, um im Stadtstaat Hamburg eine bessere Gesundheitsversorgung gewährleisten zu können.
Methoden Es wurden fünf Expert_inneninterviews mit LSBTI-Menschen und drei Fokusgruppen durchgeführt und mithilfe der qualitativen Inhaltsanalyse ausgewertet.
Ergebnisse Die Ergebnisse zeigen, dass es von zentraler Bedeutung ist, dass Fachkräfte im Gesundheitswesen eigene Annahmen und Vorurteile gegenüber LSBTI-Menschen ehrlich hinterfragen. Außerdem sollten sie insbesondere mit Herausforderungen des Coming-outs vertraut sein, diverse Lebens- und Beziehungsmodelle mitdenken, unterschiedliche Phasen der sexuellen und geschlechtlichen Entwicklung sowie Einflüsse darauf kennen, sexuelles Verhalten und sexuelle Identität unterscheiden – und all dies bei der Behandlung bzw. Beratung bedarfsgerecht berücksichtigen.
Schlussfolgerung Für eine bessere Gesundheitsversorgung sollten Fachkräfte für die allgemeinen und individuellen Herausforderungen in den Sexual- und Geschlechtsbiografien von LSBTI-Menschen sensibilisiert sein und relevante Themen direkt ansprechen.
Selbstaggression als Mediator zwischen Depression und Aggressivität
Authors: Franke Irina , Shenar Riad , Nigel Stefanie , Otte Stefanie , Büsselmann Michael , Streb Judith , Dudeck Manuela 
Published: March 2019

Zusammenfassung
Ziel der Studie Überprüfung des Zusammenhangs zwischen Depression, Selbstaggression und nach außen gerichteter Aggression.
Methodik Mittels Mediatoranalyse wurde ein möglicher Mediatoreffekt der Selbstaggression auf den Zusammenhang von Depression und externalisierter Aggression an einer Stichprobe depressiver Patienten (n = 134) untersucht.
Ergebnisse Selbstaggression mediiert den Zusammenhang von Depression und externalisierter Aggression.
Schlussfolgerung Personen mit depressiver Erkrankung, die Aggression nach außen richten, richten diese auch auf sich selbst.
Mental Health Disorders Associated with Sinonasal and Skull Base Malignancies: A Large Cohort Study
Authors: Lee Ji Hyae , Zacharia Brad E. , Ba Djibril , Leslie Douglas , Liu Guodong , Goyal Neerav 
Published: March 2019

Abstract
Objective The main purpose of this article is to examine the prevalence, incidence, sociodemographic, and clinical characteristics of mental health disorders (MHDs) among patients with skull base malignancies.
Design Retrospective cohort study.
Settings/Participants Six-thousand seven-hundred sixty sinonasal/skull base cancer patients in the MarketScan database between 2005 and 2014.
Main Outcome Measures Frequency of MHDs pre- and post-diagnosis in patients harboring sinonasal/skull base malignancies.
Results A significant increase in MHDs was noted from pre- to post-cancer diagnosis (22 vs 31%, p < 0.0001). Despite an increase in the prevalence rate, the demographic profile of patients with MHDs post-diagnosis remained similar to pre-diagnosis. Those patients harboring MHDs were, however, more likely to be women (62.7 vs 47.4%), and carry a history of smoking (40.9 vs 26.3%) than those without MHDs. These comparisons were statistically significant (p < 0.0001).
Conclusion The prevalence of MHDs increases following a diagnosis of a sinonasal/skull base malignancy. Patients with MHDs were more likely to be women and smokers.
From single drug targets to synergistic network pharmacology in ischemic stroke
Authors: Casas Ana I. , Hassan Ahmed A. , Larsen Simon J. , Gomez-Rangel Vanessa , Elbatreek Mahmoud , Kleikers Pamela W. M. , Guney Emre , Egea Javier , López Manuela G. , Baumbach Jan , Schmidt Harald H. H. W. 
Published: March 2019

Significance
Current one drug–one target–one disease approaches in drug discovery have become increasingly inefficient. Network pharmacology defines disease mechanisms as networks best targeted by multiple, synergistic drugs. Using the high unmet medical need indication stroke, we here develop an integrative in silico approach based on a primary target, NADPH oxidase type 4, to identify a mechanistically related cotarget, NO synthase, for network pharmacology. Indeed, we validate both in vivo and in vitro, including humans, that both NOX4 and NOS inhibition is highly synergistic, leading to a significant reduction of infarct volume, direct neuroprotection, and blood–brain-barrier stabilization. This systems medicine approach provides a ground plan to decrease current failure in the field by being implemented in other complex indications.
Fair ways to share benefits from community forests? How commodification is associated with reduced preference for equality and poverty alleviation
Authors: Martin Adrian , Kebede Bereket , Gross-Camp Nicole , He Jun , Inturias Mirna , Rodríguez Iokiñe 
Published: March 2019

Abstract
This research is concerned with the trend towards commodification of forestry, in the context of community forest governance for sustainable development in the tropics. In these contexts, commodification takes different forms, including sales of certified timbers and sales of carbon credits. In addition to the general aim to enhance income, these market-based forestry interventions typically aim to align with sustainable development agendas, including (a) safeguarding ecological integrity and (b) promoting poverty alleviation. Our concern here is that the process of forest commodification might lead to a shift in local norms of benefit-sharing, in ways that can hinder these key components of sustainable development goals. We report the results of a survey (N = 519) conducted across sites in Bolivia, China and Tanzania that shows that switching from non-monetary to monetary benefits is associated with changes in preferences for distributional fairness in ways that may be detrimental to the poor. In particular, we show that forest commodification is associated with a lower likelihood of selecting pro-poor or egalitarian approaches to benefit sharing and higher likelihood of selecting to distribute benefits in a way that rewards individual contributions or compensates losses.
Kunneth formula for graded rings associated to 𝐾-theories of Rost motives
Authors: Yagita Nobuaki 
Published: March 2019

In this paper, we study the graded ring

g

r
∗

(
X
)

gr^*(X)

defined by

K
K

-theory of a twist flag variety

X
X

. In particular, the Kunneth map

g

r
∗

(

R
′

)
⊗
g

r
∗

(

R
′

)
→
g

r
∗

(
R
)

gr^*(R’)\otimes gr^*(R’)\to gr^*(R)

is studied explicitly for an original Rost motive

R
′

R’

and a generalized Rost motive

R
R

. Using this, we give examples

T
o
r
(
X

)
2

≠
0

Tor(X)^2\not =0

for the ideal

T
o
r
(
X
)

Tor(X)

of torsion elements in the Chow ring

C

H
∗

(
X
)

CH^*(X)

.
Association of Pneumococcal Conjugate Vaccine Coverage With Pneumococcal Meningitis: An Analysis of French Administrative Areas, 2001–2016
Authors: Alari Anna , Cheysson Félix , Le Fouler Lénaig , Lanotte Philippe ,   Observatoires Régionaux du Pneumocoque network, Varon Emmanuelle , Opatowski Lulla , Guillemot Didier , Watier Laurence 
Published: March 2019

Abstract
Geographic variations of invasive pneumococcal disease incidence and serotype distributions were observed after pneumococcal conjugate vaccine introduction at regional levels and among French administrative areas. The variations could be related to regional vaccine coverage (VC) variations that might have direct consequences for vaccination-policy impact on invasive pneumococcal disease, particularly pneumococcal meningitis (PM) incidence. We assessed vaccine impact from 2001 to 2016 in France by estimating the contribution of regional VC differences to variations of annual local PM incidence. Using a mixed-effect Poisson model, we showed that, despite some variations of VC among administrative areas, vaccine impact on vaccine-serotype PM was homogeneously confirmed among administrative areas. Compared with the prevaccine era, the cumulative VC impact on vaccine serotypes led, in 2016, to PM reductions ranging among regions from 87% (25th percentile) to 91% (75th percentile) for 7-valent pneumococcal conjugate vaccine serotypes and from 58% to 63% for the 6 additional 13-valent pneumococcal conjugate vaccine serotypes. Nonvaccine-serotype PM increases from the prevaccine era ranged among areas from 98% to 127%. By taking into account the cumulative impact of growing VC and VC differences, our analyses confirmed high vaccine impact on vaccine-serotype PM case rates and suggest that VC variations cannot explain PM administrative area differences.
Pharmacogenomic potential in advanced cancer patients
Authors: Nichols Dan , Arnold Susanne , Weiss Heidi L , Wu Jianrong , Durbin Eric B , Miller Rachel , Kolesar Jill 
Published: March 2019

Abstract

Purpose
The prevalence of pharmacogenetically actionable medications in advanced cancer patients whose therapy may be optimized with genotype data was determined.

Methods
Patients enrolled in our institutional molecular tumor board observational cohort were included in this study. Collected data included demographics, type(s) of cancer, and outpatient medications. Medications were classified as “pharmacogenetically actionable” if there are Clinical Pharmacogenetics Implementation Consortium (CPIC) therapeutic recommendations for that medication based on the presence of germline variations. The prevalence of pharmacogenetically actionable medications in the study population was determined, and the frequency of opportunities for pharmacogenetic prescribing and adverse event (AE) mitigation were estimated.

Results
In a cohort of 193 patients with advanced cancer, 65% of patients were taking a pharmacogenetically actionable medication. Approximately 10% of the outpatient medications taken by the study population had a pharmacogenetic association. The most common pharmacogenetically actionable medications being used were ondansetron (47%), capecitabine (10%), and sertraline (7%). Using published genetic variation frequencies and AE risk, we conservatively estimated that 7.1% of cancer patients would be eligible for genetic-based medication adjustment, and 101 AEs would be prevented in 10,000 patients genotyped.

Conclusion
Medications with pharmacogenetic associations are used commonly in the advanced cancer patient population. This widespread exposure supports the implementation of prospective genotyping in the treatment of these high-risk patients.
Differential proteostatic regulation of insoluble and abundant proteins
Authors: Ramakrishnan Reshmi , Houben Bert , Rousseau Frederic , Schymkowitz Joost 
Published: March 2019

Abstract

Motivation
Despite intense effort, it has been difficult to explain chaperone dependencies of proteins from sequence or structural properties.

Results
We constructed a database collecting all publicly available data of experimental chaperone interaction and dependency data for the Escherichia coli proteome, and enriched it with an extensive set of protein-specific as well as cell-context-dependent proteostatic parameters. Employing this new resource, we performed a comprehensive meta-analysis of the key determinants of chaperone interaction. Our study confirms that GroEL client proteins are biased toward insoluble proteins of low abundance, but for client proteins of the Trigger Factor/DnaK axis, we instead find that cellular parameters such as high protein abundance, translational efficiency and mRNA turnover are key determinants. We experimentally confirmed the finding that chaperone dependence is a function of translation rate and not protein-intrinsic parameters by tuning chaperone dependence of Green Fluorescent Protein (GFP) in E.coli by synonymous mutations only. The juxtaposition of both protein-intrinsic and cell-contextual chaperone triage mechanisms explains how the E.coli proteome achieves combining reliable production of abundant and conserved proteins, while also enabling the evolution of diverging metabolic functions.

Availability and implementation
The database will be made available via http://phdb.switchlab.org.

Supplementary information
Supplementary data are available at Bioinformatics online.