bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and Outcomes of Retinal Detachment Associated With Atopic Dermatitis: A Retrospective Case Series
Authors: Grewal Parampal S. , Rubin Uriel , Greve Mark D.J. , Somani Rizwan , Baker Chad F. , Ehmann David , Tennant Matthew T.S. 
Published: February 2019

Purpose: The purpose of this article is to describe the characteristics and outcomes of retinal detachment (RD) repair associated with atopic dermatitis (AD). Methods: A single-center, retrospective review of all patients with RD associated with AD between January 2007 and December 2017 was conducted. Results: Ten patients (13 eyes) were included with a mean age of 23.5 ± 6.4 years; 6 of the patients were male (60%). The average follow-up was 41.3 ± 34.8 months. Seven eyes developed proliferative vitreoretinopathy (PVR) and recurrent RD (53.8%). The mean number of retinal surgeries was 2.3 ± 1.3. Three eyes had a scleral buckle alone (23.1%), 4 eyes had vitrectomy only (30.8%), and 6 eyes had both scleral buckle and vitrectomy (46.2%). Five eyes had prior cataract surgery (38.5%), 5 eyes had cataract at presentation (38.5%), and 5 eyes developed lens subluxation (38.5%). The mean presenting best-corrected visual acuity (BCVA) was 1.14 logarithm of the minimum angle of resolution (Snellen equivalent, 20/276) and the mean final BCVA was 1.06 (Snellen, 20/230; P = .83). The retina was successfully reattached at final follow-up in all 13 eyes (100%). Conclusions: RD is a challenging complication of AD with a high rate of PVR, recurrent RD, cataract, and lens subluxation. Patient education and physician awareness are necessary for timely diagnosis, appropriate counseling, and optimal surgical planning.
Frequent germline mutations of HAVCR2 in sporadic subcutaneous panniculitis-like T-cell lymphoma
Authors: Polprasert Chantana , Takeuchi Yasuhide , Kakiuchi Nobuyuki , Yoshida Kenichi , Assanasen Thamathorn , Sitthi Wimonmas , Bunworasate Udomsak , Pirunsarn Arunrat , Wudhikarn Kitsada , Lawasut Panisinee , Uaprasert Noppacharn , Kongkiatkamon Sunisa , Moonla Chatphatai , Sanada Masashi , Akita Nobuhiro , Takeda June , Fujii Yoichi , Suzuki Hiromichi , Nannya Yasuhito , Shiraishi Yuichi , Chiba Kenichi , Tanaka Hiroko , Miyano Satoru , Rojnuckarin Ponlapat , Ogawa Seishi , Makishima Hideki 
Published: February 2019

Abstract
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare subtype of peripheral T-cell lymphoma affecting younger patients and associated with hemophagocytic lymphohistiocytosis. To clarify the molecular pathogenesis of SPTCL, we analyzed paired tumor and germline DNAs from 13 patients by whole-exome sequencing. All cases were Asians and were phenotypically sporadic with no family history of SPTCL. Consistent with a recent report, germline mutations in HAVCR2, encoding T-cell immunoglobulin mucin 3 (TIM3), were identified in 11 of 13 (85%) cases. All mutated cases were primary SPTCL, whereas the 2 cases without mutation were secondary SPTCL associated with underlying diseases, including viral infection and autoimmune disease. Ten patients harbored homozygous p.Y82C mutations, and 1 showed compound heterozygous mutations (p.Y82C and p.T101I). Both missense mutations altered highly conserved residues located in the extracellular immunoglobulin variable–like domain. According to the Genome Aggregation Database of &gt;138 500 general individuals, both mutations were documented with minor allele frequencies &lt; 0.007, indicating remarkable enrichment of these HAVCR2 alleles in SPTCL. SPTCL cells also harbored somatic mutations (6.2 per patient) that are frequently identified in genes associated with epigenetic regulation and signal transduction. In conclusion, individuals harboring biallelic HAVCR2 (TIM3) germline mutations were highly susceptible to sporadic SPTCL, which was also associated with clonal somatic mutations.
RETRACTED ARTICLE: Long non-coding RNA LINC00968 attenuates drug resistance of breast cancer cells through inhibiting the Wnt2/β-catenin signaling pathway by regulating WNT2
Authors: Xiu Dian-Hui , Liu Gui-Feng , Yu Shao-Nan , Li Long-Yun , Zhao Guo-Qing , Liu Lin , Li Xue-Feng 
Published: February 2019

Abstract
Background
Breast cancer is one the most common cancers, making it the second leading cause of cancer-related death among women. Long non-coding RNAs (lncRNAs), with tightly regulated expression patterns, also serve as tumor suppressor during tumorigenesis. The present study aimed to elucidate the role of LINC00968 in breast cancer via WNT2-mediated Wnt2/β-catenin signaling pathway.

Methods
Breast cancer chip GSE26910 was utilized to identify differential expression in LINC00968 and WNT2. The possible relationship among LINC00968, transcriptional repressor HEY and WNT2 was analyzed and then verified. Effects of LINC00968 on activation of the Wnt2/β-catenin signaling pathway was also tested. Drug resistance, colony formation, cell migration, invasion ability and cell apoptosis after transfection were also determined. Furthermore, tumor xenograft in nude mice was performed to test tumor growth and weight in vivo.

Results
WNT2 expression exhibited at a high level, whereas LINC00968 at a low expression in breast cancer which was also associated with poor prognosis in patients. LINC00968 targeted and negatively regulated WNT2 potentially via HEY1. Either overexpressed LINC00968 or silenced inhibited activation of the Wnt2/β-catenin signaling pathway, thereby reducing drug resistance, decreasing colony formation ability, as well as suppressing migration and invasion abilities of breast cancer cells in addition to inducing apoptosis. Lastly, in vivo experiment suggested that LINC00968 overexpression also suppressed transplanted tumor growth in nude mice.

Conclusion
Collectively, overexpressed LINC00968 contributes to reduced drug resistance in breast cancer cells by inhibiting the activation of the Wnt2/β-catenin signaling pathway through silencing WNT2. This study offers a new target for the development of breast cancer treatment.
Evidence of the impacts of metal mining and the effectiveness of mining mitigation measures on social–ecological systems in Arctic and boreal regions: a systematic map protocol
Authors: Haddaway Neal R. , Cooke Steven J. , Lesser Pamela , Macura Biljana , Nilsson Annika E. , Taylor Jessica J. , Raito Kaisa 
Published: February 2019

Abstract
Background
Mining activities, including prospecting, exploration, construction, operation, maintenance, expansion, abandonment, decommissioning and repurposing of a mine can impact social and environmental systems in a range of positive and negative, and direct and indirect ways. Mining can yield a range of benefits to societies, but it may also cause conflict, not least in relation to above-ground and sub-surface land use. Similarly, mining can alter environments, but remediation and mitigation can restore systems. Boreal and Arctic regions are sensitive to impacts from development, both on social and environmental systems. Native ecosystems and aboriginal human communities are typically affected by multiple stressors, including climate change and pollution, for example.

Methods
We will search a suite of bibliographic databases, online search engines and organisational websites for relevant research literature using a tested search strategy. We will also make a call for evidence to stakeholders that have been identified in the wider 3MK project (https://osf.io/cvh3u/). We will screen identified and retrieved articles at two distinct stages (title and abstract, and full text) according to a predetermined set of inclusion criteria, with consistency checks at each level to ensure criteria can be made operational. We will then extract detailed information relating to causal linkages between actions or impacts and measured outcomes, along with descriptive information about the articles and studies and enter data into an interactive systematic map database. We will visualise this database on an Evidence Atlas (an interactive, cartographic map) and identify knowledge gaps and clusters using Heat Maps (cross-tabulations of important variables, such as mineral type and studied impacts). We will identify good research practices that may support researchers in selecting the best study designs where these are clear in the evidence base.
Adaptive waveform inversion: Practice
Authors: Guasch Lluís , Warner Michael , Ravaut Céline 
Published: February 2019

Adaptive waveform inversion (AWI) reformulates the misfit function used to perform full-waveform inversion (FWI), so that it no longer contains local minima related to cycle skipping. It does this by finding a model that drives the ratio of the predicted and observed data sets to unity rather than driving the difference between these two data sets to zero as is the case for conventional FWI. We apply AWI to a 3D field data set acquired over a pervasive gas cloud in the North Sea, comparing its performance with that of conventional FWI in a variety of circumstances. When starting inversion from 3 Hz, and using a good starting model obtained from reflection tomography, FWI and AWI generate similar models although the FWI result contains edge artifacts that are not produced by AWI. However, when the starting frequency is increased to approximately 6 Hz, or when the starting model is less accurate, FWI fails to recover a good model whereas AWI continues to converge. When both of these conditions apply, FWI fails comprehensively, leading to a model that is significantly worse than the starting model, whereas the AWI result remains largely unaffected. We applied Kirchhoff depth migration to the fully-processed data using the FWI result obtained following reflection tomography, and using the AWI result obtained from a simple one-dimensional starting model. We use the resulting migrated volumes, together with measures of residual moveout throughout the volume, to show that the AWI result from a simple starting model is at least as good as the FWI result obtained following tomography. We conclude that AWI is robust in the presence of cycle skipping on this 3D field data set, and can proceed successfully from a less-accurate starting model, and from a higher starting frequency, in circumstances in which FWI fails completely.
Delivering the Transforming Care programme: a case of smoke and mirrors?
Authors: Taylor John L. 
Published: February 2019

SummaryThe Transforming Care national plan for England to develop community services and close hospital beds for people with intellectual disabilities and/or autism was published in October 2015 and is due to finish in March 2019. In this editorial the key plan objectives are evaluated, with particular reference to people with intellectual disabilities and/or autism who offend or are at risk of offending. The conclusion is that, to date, the plan has failed to meet its targets to reduce the number of in-patients with intellectual disabilities and/or autism and to invest in community services, and the number of patients in independent sector beds is increasing.
Self-harm in older adults: systematic review
Authors: Troya M. Isabela , Babatunde Opeyemi , Polidano Kay , Bartlam Bernadette , McCloskey Erin , Dikomitis Lisa , Chew-Graham Carolyn A. 
Published: February 2019

BackgroundSelf-harm is a major public health concern. Increasing ageing populations and high risk of suicide in later life highlight the importance of identification of the particular characteristics of self-harm in older adults.AimTo systematically review characteristics of self-harm in older adults.MethodsA comprehensive search for primary studies on self-harm in older adults was conducted in e-databases (AgeLine, CINAHL, PsycINFO, MEDLINE, Web of Science) from their inception to February 2018. Using predefined criteria, articles were independently screened and assessed for methodological quality. Data were synthesised following a narrative approach. A patient advisory group advised on the design, conduct and interpretation of findings.ResultsA total of 40 articles (n = 62 755 older adults) were included. Yearly self-harm rates were 19 to 65 per 100 000 people. Self-poisoning was the most commonly reported method. Comorbid physical problems were common. Increased risk repetition was reported among older adults with self-harm history and previous and current psychiatric treatment. Loss of control, increased loneliness and perceived burdensome ageing were reported self-harm motivations.ConclusionsSelf-harm in older adults has distinct characteristics that should be explored to improve management and care. Although risk of further self-harm and suicide is high in all age cohorts, risk of suicide is higher in older adults. Given the frequent contact with health services, an opportunity exists for detection and prevention of self-harm and suicide in this population. These results are limited to research in hospital-based settings and community-based studies are needed to fully understand self-harm among older adults.Declaration of interestNone.
Adrenal Steroids in Female Hypothyroid Neonates: Unraveling an Association Between Thyroid Hormones and Adrenal Remodeling
Authors: Galanou Sofia , Chouliaras Giorgos , Girginoudis Panagiotis , Mengreli Chryssanthi , Sertedaki Amalia , Dracopoulou Maria , Farakla Ioanna , Platis Dimitris , Iliadi Alexandra , Chrousos George P , Dacou-Voutetakis Catherine , Zoumakis Emanuil , Magiakou Alexandra-Maria , Kanaka-Gantenbein Christina , Voutetakis Antonis 
Published: February 2019

Abstract

Context
The adrenal gland undergoes substantial remodeling during the neonatal period, an essential developmental process that remains incompletely understood. With respect to control over the remodeling process and, specifically, the role of thyroid hormones (THs), no human studies have been published. The effects of both hypo- and hyperthyroidism have only been evaluated in adults, focusing on the mature adrenal. Recent studies have identified expression of the TH receptor β1 in the mouse adrenal X-zone and have demonstrated that TH administration could alter the postnatal adrenal remodeling process.

Objective
To address whether THs influence adrenal steroid profiles and adrenal remodeling during the neonatal period.

Methods
We compared the adrenal steroid profile of a naturally occurring prototype, female neonates with severe congenital hypothyroidism (CH) (n = 22, upon diagnosis of CH), with that of euthyroid neonates (n = 20).

Results
Significantly higher levels of adrenal steroids (17-OH-progesterone, dehydroepiandrosterone sulfate, Δ4-androstenedione, and testosterone) were measured in neonates with severe CH compared with euthyroid neonates and returned to within normal range after euthyroid state had been established on l-thyroxine replacement therapy, whereas cortisol levels did not differ. TSH values in the CH group were positively correlated with circulating adrenal steroids, whereas free T4 levels were negatively correlated with circulating adrenal steroids.

Conclusions
The hormonal profile of female neonates with severe CH suggests a more active adrenal fetal zone compared with control subjects. These data indirectly associate THs with the adrenal remodeling and maturation process in humans. Based on our results, we suggest that severe hypothyroidism decelerates the involution of the adrenal fetal zone that normally occurs postnatally.
Stimulated Thyroglobulin and Thyroglobulin Reduction Index Predict Excellent Response in Differentiated Thyroid Cancers
Authors: Barres Bertrand , Kelly Antony , Kwiatkowski Fabrice , Batisse-Lignier Marie , Fouilhoux Geneviève , Aubert Bernadette , Dutheil Frédéric , Tauveron Igor , Cachin Florent , Maqdasy Salwan 
Published: February 2019

AbstractContextDespite its good prognosis, differentiated thyroid cancer (DTC) is characterized by high rates of disease persistence and recurrence. Estimation of long-term remission (excellent response) thanks to specific parameters could help to individualize the active surveillance schedule.ObjectiveEvaluation of the ability of stimulated thyroglobulin (Tg) and Tg reduction index (TRI) to predict long-term remission in patients with DTC managed by thyroidectomy and radioactive iodine (RAI) remnant ablation.Patients and InterventionsObservational retrospective study of 1093 patients treated for DTC between 1995 and 2010. Preablation stimulated thyroglobulin (presTg) was measured under thyroid hormone withdrawal just before RAI. Recombinant human TSH–stimulated thyroglobulin (sTg) was measured at first evaluation of the initial management 6 to 12 months after RAI. TRI was calculated based on pre-Tg and sTg.ResultsAfter univariate and multivariate analyses, lymph node invasion (N1, OR = 2.08; 95% CI, 1.19 to 3.64), presTg (OR = 4.04; 95% CI, 2.56 to 6.38), sTg (OR = 2.62; 95% CI, 2.05 to 3.34), and TRI (OR = 0.43; 95% CI, 0.21 to 0.88) were identified as independent prognostic factors influencing the rate of disease persistence or recurrence after the initial management. Receiver operating characteristic analysis identified presTg cutoff (&lt;10 µg/L) to predict excellent response, with a negative predictive value of 94%, and validated for higher stages (T3/T4, N1). Furthermore, sTg &lt;1 µg/L predicts excellent response. TRI &gt;60% for the entire cohort and 62.5% for locally advanced disease (T3/T4, N1) was sensitive predictor for excellent response.ConclusionThis study identifies presTg, sTg, and TRI as highly sensitive predictors of excellent response in patients with DTC and subsequently disease-free status. The cutoff of such parameters is also adapted for patients with higher tumor stages (T3/T4, N1).
Intersectionality, Depression, and Voter Turnout
Authors: Ojeda Christopher , Slaughter Christine M. 
Published: February 2019

AbstractContext: This article untangles the effects of depression on voter turnout among blacks and whites and among women and men and considers several factors—income, health insurance, church attendance, group consciousness, and empowerment—that may mitigate the negative effects of depression on turnout.Methods: The authors estimated regression models of voter turnout on depression across race and gender groups using data from the Panel Study of Income Dynamics and the National Longitudinal Study of Adolescent to Adult Health. They used interaction terms to assess whether the effect of depression is conditional on the potential mitigating factors.Findings: Reporting increased depressive symptoms was associated with a lower probability of voting across electoral contexts for all respondents, and few factors mitigated this negative effect. Only in the case of black men did the authors find that a coethnic candidate mitigated the negative effect of depression, while a higher level of group consciousness did the opposite.Conclusions: The effect of depression was strong, cut across racial and gender groups, and was generally robust to the effects of income, health insurance, church attendance, group consciousness, and empowerment. More research is required to understand how to reduce depression and improve turnout among those who experience it.
Acute Exercise Prevents Angry Mood Induction but Does Not Change Angry Emotions
Authors: THOM NATHANIEL J. , O’CONNOR PATRICK J. , CLEMENTZ BRETT A. , DISHMAN ROD K. 
Published: February 2019

ABSTRACT

Introduction
Exercise is well known to enhance a variety of mood states, but few studies have been specifically designed to investigate whether acute aerobic exercise alters feelings of anger. The goal of this study was to determine the magnitude of the effects of acute exercise on both angry mood and angry emotions.

Methods
Angry mood and angry emotions were assessed in 16 men with elevated trait anger who viewed a variety of emotionally evocative scenic pictures before and after 30 min of moderate- to vigorous-intensity aerobic exercise. Angry mood, captured by self-reports of state anger, angry emotions, as indexed by event-related brain activity (e.g., early posterior negativity and late positive potential), and self-reports of anger intensity were measured.

Results
The results indicate that acute exercise both 1) reduces angry mood and 2) mitigates angry mood induction but does not change the intensity of angry emotions or the associated event-related potential responses to anger-inducing pictures in college-age men who have elevated trait anger.

Conclusion
Future studies should explore the mechanisms underlying the effect of exercise on preventing angry mood induction, consider alternative anger induction methods that might induce higher levels of angry emotions, and test the effects of chronic exercise training on anger and its expression.
Cerebral Blood Flow during Interval and Continuous Exercise in Young and Old Men
Authors: KLEIN TIMO , BAILEY TOM G. , ABELN VERA , SCHNEIDER STEFAN , ASKEW CHRISTOPHER D. 
Published: February 2019

ABSTRACT

Purpose
Aging is associated with impaired cerebral blood flow (CBF) and increased risk of cerebrovascular disease. Acute increases in CBF during exercise may initiate improvements in cerebrovascular health, but the CBF response is diminished during continuous exercise in older adults. The effect of interval exercise for promoting increases in CBF in young and old adults is unknown.

Methods
We compared middle cerebral artery blood velocity (MCAv), end-tidal CO2 (PETCO2) and blood pressure (mean arterial pressure [MAP]) during intensity- and work-matched bouts of continuous (10-min 60%W
max, followed by 10-min rest) and interval cycling (10 × 1-min 60%W
max, separated by 1-min rest) in 11 young (25 ± 3 yr) and 10 old (69 ± 3 yr) men.

Results
Middle cerebral artery velocity was higher during continuous compared with interval exercise in the young (P < 0.001), but not in the old. This trend was also seen for changes in PETCO2. Although absolute MAP was higher in the old, the relative rise (%∆) in MAP was similar between age groups and was greater during continuous exercise than interval. When we assessed the total accumulated change in MCAv (area under curve: exercise + recovery), it was higher with interval compared with continuous exercise in both groups (P = 0.018).

Conclusion
These findings suggest that interval exercise may be an effective alternative for promoting acute increases in CBF velocity, particularly in those older adults who may have difficulty sustaining continuous exercise.