bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra Minimally Invasive Surgical Stabilization of Rib Fractures (uMI-SSRF): Reduction and Fixation techniques to minimize the surgical wound
Authors: LO HON LOK , Lee Jui-Ying , Lu Chun Kuan , Lo On-Yee , Lu Cheng-Chang , Tsai Dong-Lin 
Published: November 2024

Abstract

Background:
Rib fractures are common in trauma patients, often leading to complications such as pneumonia and prolonged hospitalization. Surgical Stabilization of Rib Fractures (SSRF) has become increasingly prevalent in treating severe cases. However, traditional approaches, like posterolateral thoracotomy, are invasive and cause significant muscle damage. Recently, muscle-sparing minimally invasive techniques have been introduced, yet they still require advanced reduction and fixation techniques to avoid complications. This study presents an "ultra" minimally invasive SSRF (uMI-SSRF) technique designed to minimize surgical wounds and soft tissue damage while maintaining the benefits of rib fixation.
Methods:
This study involved 76 patients with multiple rib fractures treated using the uMI-SSRF technique between August 2021 and December 2023. Preoperative chest tomography with 3D reconstruction was used for surgical planning. The technique employed small incisions (3-5 cm), muscle-sparing approaches, and advanced fixation techniques. Data on patient demographics, intraoperative details, and postoperative outcomes were collected.
Results:
The mean patient age was 58 years, with 66% being male. On average, patients had 6.4 fractured ribs, and 4 ribs were fixed per surgery, achieving a fixation ratio of 59%. The average wound length was 4.2 cm, with a mean operation time of 122 minutes. Most patients required one incision (74%). Median hospital length of stay was 7 days, with a pneumonia rate of 5%. No wound infections or implant-related complications were observed.
Conclusions:
The uMI-SSRF technique effectively reduces wound size and soft tissue damage in rib fracture stabilization while maintaining high fixation quality. This method shows promise for improving patient outcomes, reducing recovery time, and minimizing complications. Further studies with larger sample sizes and comparisons with other methods are warranted to verify the advantages of uMI-SSRF.
Bromatological Analysis of Marine Macroalgae Present in the Central Coast of Manabí, Ecuador
Authors: ESPAÑA JUAN NAPA , SORNOZA KESHIA PICO , MENDOZA JESÚS BRIONES , ALIÓ JOSÉ JAVER , QUIJIJE LUBER 
Published: November 2024

Abstract

Macroalgae play an important role in maintaining the overall balance of the planet, not only through oxygen production but also due to their importance as the foundation of food webs, climate regulation, habitats, nutrient cycles, and their commercial value to humans. The purpose of this study was to determine the richness of marine macroalgae species along the coastal profile of the central zone of Manabí, Ecuador, their bromatology, and presence of heavy metals, as a contribution to the knowledge of the nutritional potential of these species. Three zones were selected for their composition: Punta Blanca-Jaramijó, Barbasquillo-Manta and Puerto Cayo, where algal species samples were collected according to established protocols. Monthly bromatological analyses of three species, Ulva Lactuca, Padina pavonica and Caulerpa racemosa, were performed from August 2018-July 2019. A total of 18 macroalgae species were identified, belonging to three phyla: Chlorophyta, Ochrophyta, and Rhodophyta, with Lobophora variegata (Ochrophyta: Phaeophyta) being the most frequently recorded species. Regarding the bromatological analyses, humidity and ash contents varied in a cyclical and inverse way, with higher humidity values from August to December. Lipid content was ≤ 3% while protein content in Ulva lactucavaried in the range 17.5 – 0.6%, while the other species between 5 – 0.33%. A high concentration of Mn was observed among minerals, providing guidelines for future beneficial research. The ecotoxicological tests (heavy metals) showed values above the permissible normal indices, highlighting the need to consider these results for the conservation and recovery of contaminated areas.
Different Findings in Neonate Carbamyl-Phosphate Synthetase I Deficiency Disease
Authors: Jiang Shou-Liang , He Qi , Zhang Li , Tang Jun 
Published: November 2024

Abstract

Background
Carbamyl-Phosphate Synthetase I Deficiency Disease (CPS1) is a rare condition that is a disorder of the urea cycle. It often results in severe hyperammonaemia with poor prognosis due to inappropriate feeding.
Case presentation:
We report a case of a patient admitted with poor response and jaundice, with initial metabolic screening suggestive of hyperammonemia, refinement of blood and urine metabolic screening and second-generation sequencing clarifying CPS1, who was discharged from the hospital cured after a synergistic course of peritoneal dialysis, haemoexchange therapy, haemodialysis and oral ammonia-lowering medications. The patient was neurologically assessed for only mild brain damage and recovered.
Conclusion
Severe forms of CPS1 can also have excellent outcomes if early detection and treatment are achieved. Blood exchange therapy combined with peritoneal dialysis might be a less invasive treatment for patients in the acute phase.
The clinical trial number:
not applicable.
What is behind high turnover intention among hospital nurses during the full liberalization of COVID-19 and post-pandemic era in China: a 2-wave repeated multicenter survey
Authors: Xiao Julan , Liu Lili , Peng Yueming , Lv Xia , Xing Chunfeng , Tao Yanling , Zhu Shening , Mai Aihuan , Liang Lijun , Hu Hongying , Fan Yi , Peng Weisi , Xie Haishan , Ren Jun , Luo Weixiang 
Published: November 2024

Abstract

Background
The COVID−19 pandemic was a major public health crisis, which has exacerbated the difficulties nurses face, resulting in higher turnover rates and workforce shortages. While many early studies that have examined factors contributing to turnover intention, surprisingly, as yet, no studies have compared the turnover intention of Chinese hospital nurses during the full liberalization of COVID−19 period and post-pandemic era, and it is unclear which potential factors may be associated with turnover intention of nurses at the different periods. This 2-wave repeated survey purposed to explore the prevalence and correlates of turnover intention at different stages of the full liberalization of COVID−19 and post-pandemic era in a large sample of nurses in China.
Method
Using a repeated cross-sectional survey design, we conducted two online surveys at 25 hospitals in Guandong, China. The 2 surveys were conducted during the full liberalization of COVID−19 period (T1: 27 December 2022 to 7 January 2023, N = 1,766), and post-pandemic era (T2: 11 May to 23 May 2023, N = 2,643). Turnover intention was measured by the six-item Turnover Intention Scale (TIS). A range of turnover intention-related factors was assessed, including sociodemographic characteristics, preceived stress, anxiety, depression, insomnia, job burnout, intolerance of uncertainty, satisfaction with life, and work-related factors.
Results
The prevalence of turnover intention were 73.33% and 72.34% at T1 and T2, respectively. Dissatisfaction with nursing work (aOR: 2.160–6.536, Ps < 0.001), lack of interest in nursing (aOR: 2.513–2.802, Ps < 0.001) and job burnout (aOR: 1.360–4.096, Ps < 0.01) were associated with an increased risk of turnover intention. And satisfaction with life (aOR: 0.343–0.683, Ps < 0.05) was associated with a reduced risk of turnover intention.
Conclusions
Turnover intention were particularly higher both in the full liberalization of COVID−19 period and the post-pandemic era. Multiple factors, especially dissatisfaction with nursing work, lack of interest in nursing, job burnout and satisfaction with life are associated with turnover intention. Early detection of turnover intention among hospital nurses and preventive and promotive interventions should be implemented during the full liberalization of COVID−19 and the post-pandemic era to reduce turnover intention among nurses.
Pollen–pistil interactions in divergent wide crosses lead to spatial and temporal pre-fertilization reproductive barrier in flax (Linum usitatissimum L.)
Authors: Raut Vijaykumar Kailasrao , Yadav Aneeta , Kaur Vikender , Rao Mahesh , Pathania Pooja , Wankhede Dhammaprakash , Singh Mamta , Singh Gyanendra Pratap 
Published: November 2024

Abstract

Linseed, has been a source of natural fiber for terxtile industries since its domestication. However, despite being the potential source of trait reservoir, the use of Linum wild genetic resources for the improvement of economic traits are not exploited widely. This is mainly due to the degree of genetic divergence that exists among the interspecific ecotypes causing crossability issues. Self-incompatibility due to the occurrence of heterostyly is very well reported in distantly related crop wild relatives of Linum and, the mechanism of self-incompatibility between different floral morphs is also studied. However, pollen germination and tube growth responses in the interspecific crosses are rarely studied. Thus, the present study was exclusively carried out to assess the major pre-zygotic barriers and their effect on pollen germination on foreign stigma using fluorescent microscopy of aniline blue stain-aided technology, to understand how the species barriers operate on pollen germination and pollen tube growth. The study revealed that the pollen-pistil interaction in the wide crosses among L. usitatissimum X L. grandiflorum was regulated by both temporal and spatial pre-fertilization barriers. Callose deposition within 2 hours after pollination (HAP) at the stigma surface, was the major cause inhibiting pollen germination. Various kinds of aberrations started appearing during the 2-4HAP. The complexity of interspecific hybridization was observed in terms of arrest of pollen tube (PT) growth in the ovary, ruptured, twisted and swollen pollen tube tip, tube growth in reverse direction, convoluted and terminated growth patterns. The results suggest that although, distant hybridization is usually less efficient, hybridization success can be improved by advanced techniques such as embryo rescue and in vitro culture of isolated immature embryos that will undoubtedly yield crucial information on selecting the ideal culture conditions and medium, paving the way for groundbreaking discoveries in this field.
Long-term impact of pregnancy on mortality and graft outcomes in kidney transplant recipients: a systematic review and meta-analysis
Authors: Kanbay Mehmet , Brinza Crischentian , Ozbek Lasin , Unlu Selen , Abdel-Rahman Sama Mahmoud , Guldan Mustafa , Aktas Ozgur , Covic Andreea , Burlacu Alexandru , Covic Adrian 
Published: November 2024

Abstract

Background and aim: Pregnancy in kidney transplant recipients involves complex physiological changes that could potentially impact long-term graft function and survival. Despite some evidence suggesting minimal long-term effects on graft survival, conflicting results on graft function and timing-related risks highlight the need for a comprehensive review. This systematic review and meta-analysis aim to evaluate the long-term impact of pregnancy on patient survival, graft failure, serum creatinine levels, estimated glomerular filtration rate (eGFR), and proteinuria in kidney transplant recipients.
Materials and methods: We conducted a systematic review and meta-analysis adhering to PRISMA guidelines and registered with PROSPERO (CRD42024569702). We searched PubMed, Scopus, Web of Science, Cochrane Library, and Ovid MEDLINE. Studies were eligible if they provided data on adult kidney transplant recipients (>18 years) who became pregnant post-transplant and included a control group of non-pregnant or non-conceived individuals.
Results: Among the 6,118 results screened, 19 studies met the eligibility criteria and were included in the meta-analysis. The risk of allograft failure or graft loss was similar between pregnant and non-pregnant controls (OR 1.13, 95% CI: 0.83–1.53, p = 0.43), with a slightly higher adverse outcome rate in pregnant patients (25.4% vs. 19.8%). All-cause mortality risk was also comparable (OR 0.63, 95% CI: 0.38–1.07, p = 0.09), with low heterogeneity (I² = 12%). Creatinine levels were significantly lower before pregnancy compared to after delivery (SMD -0.33, 95% CI: -0.52 to -0.14, p = 0.0008).
Conclusion: Pregnancy in kidney transplant recipients leads to increased creatinine levels in postpartum but does not significantly affect long-term graft survival. While creatinine levels generally decrease during pregnancy, they show variability by trimester. The risk of allograft failure and mortality is similar between pregnant and non-pregnant recipients, though adverse outcomes are slightly more frequent in pregnant patients, emphasizing the need for careful monitoring and individualized management.
Disclosing the potential mechanisms of Amomi Fructus phenolic compounds inducing ferroptosis in SGC-7901 gastric cancer cells: a joint network pharmacology-based analysis
Authors: Lv Yana , Xia Bin , Shi Wei , Mou Yan , Su Jing , Ding Xuan , Zhang Lixia , Li Guang , Chen Xi 
Published: November 2024

Abstract

Objectives
This study aimed to elucidate the mechanisms by which Amomi Fructus phenolic compounds (AFPC) induce ferroptosis in gastric cancer (GC) using a combination of network pharmacology and experimental validation.
Methods
Targets associated with AFPC, ferroptosis, and GC were compiled, and a component-target network was constructed to identify key compounds. Hub targets of AFPC-induced ferroptosis in GC were determined through protein-protein interaction (PPI) network analysis. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses were conducted to assess these hub targets. The hub targets' mRNA and protein expression levels were evaluated using UALCAN, GEPIA, Kaplan-Meier Plotter, HPA, and TISCH1. Molecular docking and molecular dynamics (MD) simulations were performed to determine the binding affinity and stability between hub targets and active compounds. Finally, in vitro cell experiments validated the network pharmacology findings. Finally, in vitro cell experiments validated the network pharmacology findings.
Results
Two main active compounds, gallic acid and quercetin, and five hub targets—TP53, HIF1A, IL6, STAT3, and EGFR—were identified. GO and KEGG analyses indicated that AFPC treatment in GC primarily involves oxidative stress, nuclear localization, p53 binding, and cancer-associated pathways. Molecular docking and simulations suggested that gallic acid and quercetin inhibit GC through modulating hub targets. Experimental results demonstrated that gallic acid and quercetin suppress GC cell viability and induce ferroptosis in SGC7901 cells by elevating Fe2+, MDA, and reducing GSH levels. The expressions of p-STAT3, STAT3, and IL-6 were significantly downregulated.
Conclusions
This study suggests that AFPC inhibits GC cell proliferation and induces ferroptosis by blocking the IL-6/STAT3 pathway.
Climate seasonality and predictability during the Middle Stone Age and implications for technological diversification in early Homo sapiens
Authors: Timbrell Lucy , Clark James , Linares-Matás Gonzalo , Boisard Solène , Arous Eslem Ben , Blinkhorn James , Grove Matt , Scerri Eleanor M. L. 
Published: November 2024

Abstract

Regionalisation is considered to be a hallmark of the Middle Stone Age (MSA) compared to the Early Stone Age. Yet what drove diversification around a shared technological substrate that persisted across Africa for hundreds of thousands of years remains debated. Non-mutually exclusive hypotheses include region-specific styles in manufacture, social signalling, cultural drift between geographically isolated populations,, and diverse environmental adaptations, as well as the impacts of unequal research histories and intensities. We explore the potential ecological bases of behavioural diversity during the MSA between two well-studied and diverse areas: eastern and northwestern Africa. We utilise a set of standardised bioclimatic simulations, as well as a time series decomposition algorithm, to determine the nature and extent of regional differences in terms of environmental productivity, seasonality and predictability at MSA sites through time. Our results highlight that, compared to human occupations of eastern Africa, northwestern African MSA occupations are associated with colder, drier and less productive environments, albeit wetter, colder, and more productive compared to surrounding areas, with higher temperature seasonality and more predictable climates across millennia. We then theoretically consider the implications of our results for technological diversification between these two regions during the Middle to Late Pleistocene, such as for the investment in specific risk mitigation strategies for dealing with seasonally mobile resources in northern localities, and the diversification of flexible MSA toolkits in tropical eastern Africa.
The Impact of Intra-tumoral and Sera Matrix Metalloproteinase 9 Levels on Glioblastoma and Brain Metastases Patients' Survival
Authors: Kaisman-Elbaz Tehila , Haddad-Shlaifshtein Snir , Eskira Yael , Merkin Vladimir , Dumanis Guy , Turiel Sivan , Atar-Vardi Maya , Bari Romi , Alt Adi , Zamed Tali , Rotem-Dai Noa , Lavrenkov Konstantin , Kezerle Yarden , Dyomin Victor , Razon Ronit , Chakraborty Moumita , Asraf Hila , Hershfinkel Michal , Melamed Israel 
Published: November 2024

Abstract

Purpose: Matrix metalloproteinase 9 (MMP-9) has been shown to induce glioblastoma and brain metastases (BM) development and spread. However, its clinical significance for monitoring disease progression has yet to be established. This study evaluates intra-tumoral and sera MMP-9 levels and their influence on glioblastoma and BM patients' overall survival (OS).
Methods: 92 tumor and pre-operative sera samples were obtained from the brain tumor bank of the neurosurgery department at Soroka University Medical Center from patients who underwent tumor resection between 2015 and 2021. Clinical and imaging data from 27 glioblastoma and 30 BM patients were analyzed, and their MMP-9 levels and activity were measured and compared with meningioma patients and healthy subjects. Survival analyses were performed to examine the impact of MMP-9 level, activity, and clinical parameters on patients' OS.
Results: Glioblastoma and BM patients demonstrated increased median intra-tumoral MMP-9 levels (8ng/ml and 4ng/ml, respectively, p<0.001), activity, and pre-operative sera levels (2.8ng/ml and 1.8ng/ml, respectively, p<0.001). MMP-9 was specifically detected within and between glioblastoma cells and tumor endothelia. High intra-tumoral and sera MMP-9 levels, but not its activity, were linked to decreased OS in glioblastoma and BM patients (15.8 versus 8.4 months, p=0.022). Sera MMP-9 was readily measured in patient sera.
Conclusions: This study suggests that intra-tumoral and sera MMP-9 can assist in identifying glioblastoma and BM recurrence/progression and that high intra-tumoral and/or sera MMP-9 levels at diagnosis correlate with significantly shorter patient OS. Importantly, sera MMP-9 could be longitudinally and non-invasively monitored in those patients and, once rising, may indicate tumor progression.
Lying mirror
Authors: Ozcan Aydogan , Li Yuhang , Chen Shiqi , Bai Bijie 
Published: November 2024

Abstract

We introduce an all-optical system, termed the “lying mirror”, to hide input information by transforming it into misleading, ordinary-looking patterns that effectively camouflage the underlying image data and deceive the observers. This misleading transformation is achieved through passive light-matter interactions of the incident light with an optimized structured diffractive surface, enabling the optical concealment of any form of secret input data without any digital computing. These lying mirror designs were shown to camouflage different types of input image data, exhibiting robustness against a range of adversarial manipulations, including random image noise as well as unknown, random rotations, shifts, and scaling of the object features. The feasibility of the lying mirror concept was also validated experimentally using a structured micro-mirror array along with multi-wavelength illumination at 480, 550 and 600 nm, covering the blue, green and red image channels. This framework showcases the power of structured diffractive surfaces for visual information processing and might find various applications in defense, security and entertainment.
Incidence and Predictors of Secondary Transmission of Ebola among Contacts in Central Uganda in 2022: A Retrospective Cohort Study
Authors: Mulongo Muhamed , Matovu Joseph K. B. , Lubaale Yovani A. M. , Olupot-Olupot Peter 
Published: November 2024

Abstract

Background
Ebola virus disease (EVD) is a highly lethal zoonotic viral hemorrhagic fever that is responsible for 41 outbreaks. In 2022, Uganda experienced its sixth EVD outbreak, with 164 cases and a case fatality rate of 39%. Secondary transmission is a key driver of the magnitude and complexity of Ebola outbreaks. This study aimed to determine the incidence, predictors, and survival outcomes associated with secondary transmission during the 2022 Ebola outbreak in Uganda.
Methods
We conducted a retrospective cohort study leveraging surveillance data collected during the 2022 EVD outbreak in Uganda. The study population comprised individuals identified as Ebola cases or contacts. Data were extracted and subjected to rigorous statistical analysis via STATA version 15. This analysis involved calculating incidence rates and survival outcomes and assessing predictors of secondary transmission through appropriate multivariable regression models, ensuring robustness in the findings and controlling for potential confounders. The study protocol was approved by the Busitema University Research Ethics Committee (BUFHS-2023-145) and the Uganda National Council of Science and Technology (HS3947ES). Individual informed consent was waived, and all the data were anonymized.
Results
A total of 3,140 contacts were included in the study, with 50.64% being female and a mean age of 24 years. The incidence rate of EVD was 1.6 cases per 1,000 person-days of follow-up. Survival rates for those diagnosed with Ebola significantly declined between the 10th and 28th days postexposure. The incidence of Ebola in secondary transmission settings was 1.8 times higher than that in primary transmission settings (IRR = 1.81, 95% CI = 1.202–2.735; P < 0.001). Significant predictors of Ebola transmission included high-risk contact status (aHR = 2.5, 95% CI: 1.68–3.72; P < 0.001) and male sex in secondary transmission settings (aHR = 2.14, 95% CI = 1.15–4.01; P = 0.02).
Conclusions
This study revealed a high incidence of Ebola among contacts, with cases emerging beyond the standard 21-day follow-up period. The incidence was notably higher in secondary transmission settings, with high-risk contacts and males being particularly vulnerable. These findings suggest the need to extend the contact follow-up period beyond 21 days and to prioritize follow-up on the basis of risk stratification. Further research is warranted to explore sex-related differences in secondary transmission dynamics.