bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections
Authors: Hoogerwerf Marie-Astrid , Coffeng Luc E , Brienen Eric A T , Janse Jacqueline J , Langenberg Marijke C C , Kruize Yvonne C M , Gootjes Chelsea , Manurung Mikhael D , Dekker Mark , Becker Luke , Erkens Marianne A A , van der Beek Martha T , Ganesh Munisha S , Feijt Carola , Winkel Beatrice M F , Westra Inge M , Meij Pauline , Loukas Alex , Visser Leo G , de Vlas Sake J , Yazdanbakhsh Maria , van Lieshout Lisette , Roestenberg Meta 
Published: May 2019

AbstractFour healthy volunteers were infected with 50 Necator americanus infective larvae (L3) in a controlled human hookworm infection trial and followed for 52 weeks. The kinetics of fecal egg counts in volunteers was assessed with Bayesian multilevel analysis, which revealed an increase between weeks 7 and 13, followed by an egg density plateau of about 1000 eggs/g of feces. Variation in egg counts was minimal between same-day measurements but varied considerably between days, particularly during the plateau phase. These analyses pave the way for the controlled human hookworm model to accelerate drug and vaccine efficacy studies.
Anti-Inflammatory Interleukin 10 Inversely Relates to Coronary Atherosclerosis in Persons With Human Immunodeficiency Virus
Authors: Fourman Lindsay T , Saylor Charles F , Cheru Lediya , Fitch Kathleen , Looby Sara , Keller Kiana , Robinson Jake A , Hoffmann Udo , Lu Michael T , Burdo Tricia , Lo Janet 
Published: May 2019

Abstract
Interleukin 10 (IL-10) is an anti-inflammatory cytokine that may be protective against coronary atherosclerosis. In an observational study of persons with human immunodeficiency virus (PWH) and uninfected controls, IL-10 was measured in serum samples by means of enzyme-linked immunosorbent assay, and coronary atherosclerosis was assessed using computed tomographic angiography. Among PWH, a 10-fold decrease in IL-10 was associated with a 2.6-fold increase in the odds of coronary plaque (P = .01), after controlling for traditional and nontraditional cardiovascular risk factors. IL-10 was also inversely associated with total coronary plaque (ρ = −0.19; P = .02) and noncalcified coronary plaque (ρ = −0.24; P = .004). Our findings suggest a role for IL-10 in mitigating atherosclerosis in PWH.
Clinical Trials Registration. NCT00455793
BEEF SPECIES–RUMINANT NUTRITION CACTUS BEEF SYMPOSIUM: Energy and roughage levels in cattle receiving diets and impacts on health, performance, and immune responses1
Authors: Richeson John T , Samuelson Kendall L , Tomczak Dexter J 
Published: May 2019

AbstractTransition of newly received feedlot cattle from a forage- to grain-based diet is challenging, and the appropriate roughage level in receiving diets is debatable. Nutritionists must consider the paradox of dietary transition and roughage level to mitigate ruminal acidosis, yet concomitantly low feed intake presents difficulty in achieving nutrient requirements when metabolic demand is increased due to inherent stress and disease challenge during the receiving period. Previous research suggests that performance is improved at the expense of increased morbidity for newly received cattle consuming diets with less roughage and greater starch concentration. The clinical signs of bovine respiratory disease (BRD) and acute acidosis are analogous; therefore, it is probable that acidotic cattle are incorrectly diagnosed with BRD in both research and production settings. Additional research efforts have attempted to elucidate alterations in microbial populations and digestion, physiological response to inflammatory challenge, and immunological response to infectious bovine rhinotracheitis virus challenge in cattle consuming diets of various roughage levels. Furthermore, our understanding of the rumen microbiome is improving rapidly with culture-independent assays, products such as direct-fed microbials are available, and increased availability and use of fibrous byproduct ingredients requires further attention. Beef cattle nutritionists and producers should consider that the health benefit of receiving diets containing greater levels of roughage and lower energy may not compensate for the reduction in performance compared with feeding receiving diets with lower roughage and greater energy.
Sublethal Effects of Four Insecticides on the Seven-Spotted Lady Beetle (Coleoptera: Coccinellidae)
Authors: Tengfei Liu , Yao Wang , Lixia Zhang , Yongyu Xu , Zhengqun Zhang , Wei Mu 
Published: May 2019

Abstract
To further develop integrated pest management (IPM) strategies against two sucking insect pests, Aleurocanthus spiniferus (Quaintanca) (Hemiptera: Aleyrodidae) and Toxoptera aurantii Boyer (Hemiptera: Aphididae), in Chinese tea plantations, it is important to evaluate the effects of insecticides on biological control agents, such as the seven-spot lady beetle, Coccinella septempunctata L. (Coleoptera: Coccinellidae). Therefore, we tested the toxicity and sublethal effects of spirotetramat, clothianidin, lambda-cyhalothrin, and bifenthrin on C. septempunctata. The side effects of the active ingredients of the insecticides were evaluated with residual contact tests on the larvae of C. septempunctata in the laboratory. Spirotetramat and clothianidin exhibited lower lethality to C. septempunctata as shown by the higher LC50 values and had higher selectivity for A. spiniferus and T. aurantii based on the selective toxicity ratios being superior to other tested insecticides. Spirotetramat also did not affect survival, longevity, fecundity, and egg hatching of C. septempunctata. Clothianidin and bifenthrin prolonged the duration of larval development stages of C. septempunctata obviously. Clothianidin at >2.5 mg/liter, lambda-cyhalothrin at >0.03 mg/liter, and bifenthrin at >0.125 mg/liter significantly reduced the survival and pupation rates of C. septempunctata larvae. Furthermore, spirotetramat at 3.125 mg/liter was harmless (IOBC class 1) to larvae of this coccinellid species. Based on the results, spirotetramat was innocuous to C. septempunctata larvae compared with clothianidin, lambda-cyhalothrin, and bifenthrin. Therefore, spirotetramat might be incorporated into IPM programs in combination with C. septempunctata for control of A. spiniferus and T. aurantii in the tea plantations.
Effect of Bark Application With Beauveria bassiana and Permethrin Insecticide on the Walnut Twig Beetle (Coleoptera: Curculionidae) in Black Walnut Bolts
Authors: Mayfield Albert E , Juzwik Jennifer , Scholer Jamison , Vandenberg John D , Taylor Adam 
Published: May 2019

Abstract
Formulations of entomopathogenic (insect-killing) fungi represent alternatives to synthetic insecticides in the management of forest and shade tree insects. We evaluated bark spray applications of the entomopathogen Beauveria bassiana (Balsamo) Vuillemin (Hypocreales: Cordycipitaceae) strain GHA (BotaniGardES), permethrin insecticide (Astro), and water (control) on colonization of black walnut (Juglans nigra L.) (Fagales: Juglandaceae) bolts by the walnut twig beetle (Pityophthorus juglandis Blackman) (Coleoptera: Curculionidae), vector of the fungus that causes thousand cankers disease. Treated bolts were baited with a P. juglandis aggregation pheromone lure and deployed in infested walnut trees. Bark application of permethrin prevented P. juglandis colonization of the phloem. Although treatment of bolts with the B. bassiana suspension did not reduce P. juglandis colonization or short-term emergence relative to the control treatment, it increased the B. bassiana infection rate from 25 to 62% of emerged adults. Results suggest that commercial applications of B. bassiana strain GHA may help augment natural levels of infection by this entomopathogen in the eastern United States, and support continued exploration of entomopathogens for biological control of the walnut twig beetle.
Immunotherapy for Colorectal Cancer: A Review of Current and Novel Therapeutic Approaches
Authors: Franke Aaron J , Skelton William Paul , Starr Jason S , Parekh Hiral , Lee James J , Overman Michael J , Allegra Carmen , George Thomas J 
Published: May 2019

Abstract
Colorectal cancer (CRC) remains a leading cause of cancer-related deaths in the United States. Although immunotherapy has dramatically changed the landscape of treatment for many advanced cancers, the benefit in CRC has thus far been limited to patients with microsatellite instability high (MSI-H):DNA mismatch repair–deficient (dMMR) tumors. Recent studies in the refractory CRC setting have led to US Food and Drug Administration approvals for pembrolizumab as well as nivolumab (with or without ipilimumab) for tumors harboring an MSI-H:dMMR molecular profile. Several randomized controlled trials are underway to move immunotherapy into the frontline for metastatic cancer (with or without chemotherapy) and the adjuvant setting. Awareness of these studies is critical given the relatively low incidence (approximately 3%–5%) of MSI-H:dMMR in advanced or metastatic CRC to support study completion, because the results could be potentially practice changing. The real challenge in this disease is related to demonstrating the benefit of immunotherapy for the vast majority of patients with CRC not harboring MSI-H:dMMR. Given the rapid pace of scientific changes, this article provides a narrative review regarding the current landscape of immunotherapy for CRC. Particular attention is paid to the currently available data that inform today’s clinical practice along with upcoming randomized controlled trials that may soon dramatically change the treatment landscape for CRC.
Combined Effects of Hemlock Woolly Adelgid (Adelges tsugae) Infestation and Treatment with Imidacloprid on Eastern Hemlock (Tsuga canadensis) Leaf Radiometry
Authors: Garris Heath W , Settle Thomas H , Crossman Jonathan E , Grider Stephen J , Michaels Shawnté L 
Published: May 2019

Abstract
The neonicotinoid systemic insecticide imidacloprid has proven to be an effective treatment for the prevention and control of hemlock woolly adelgid (Adelges tsugae Annand) in southeastern populations of eastern hemlock (Tsuga canadensis L.). Recent studies have demonstrated that imidacloprid and A. tsugae both stimulate salicylic acid-dependent physiological responses in plant tissues responsible for plant defenses against pathogens, timing of developmental outcomes including flowering and leaf senescence, and resilience to abiotic stressors. We evaluated the interacting effects of A. tsugae presence/absence and treatment with imidacloprid on leaf optical properties indicative of photosynthetic potential, photosynthetic efficiency, and tissue senescence. Our results indicated that A. tsugae changes lower canopy leaf optical properties indicative of reduced photosynthetic potential/efficiency and accelerated senescence in mature leaves. Imidacloprid was associated with declines in photosynthetic potential and showed a largely similar, though less pronounced, effect on leaf spectral properties to that of A. tsugae.
Computing three-point correlation function randoms counts without the randoms catalogue
Authors: Pearson David W , Samushia Lado 
Published: May 2019

ABSTRACT
As we move towards future galaxy surveys, the three-point statistics will be increasingly leveraged to enhance the constraining power of the data on cosmological parameters. An essential part of the three-point function estimation is performing triplet counts of synthetic data points in random catalogues. Since triplet counting algorithms scale at best as $\mathcal {O}(N^2\log N)$ with the number of particles and the random catalogues are typically at least 50 times denser than the data; this tends to be by far the most time-consuming part of the measurements. Here, we present a simple method of computing the necessary triplet counts involving uniform random distributions through simple one-dimensional integrals. The method speeds up the computation of the three-point function by orders of magnitude, eliminating the need for random catalogues, with the simultaneous pair and triplet counting of the data points alone being sufficient.
ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma
Authors: Tsvankin Vadim , Hashizume Rintaro , Katagi Hiroaki , Herndon James E , Lascola Christopher , Venkatraman Talaignair N , Picard Daniel , Burrus Brainard , Becher Oren J , Thompson Eric M 
Published: May 2019

Abstract

BACKGROUND
An impermeable blood–brain barrier and drug efflux via ATP-binding cassette (ABC) transporters such as p-glycoprotein may contribute to underwhelming efficacy of peripherally delivered agents to treat diffuse intrinsic pontine glioma (DIPG).

OBJECTIVE
To explore the pharmacological augmentation of convection-enhanced delivery (CED) infusate for DIPG.

METHODS
The efficacy of CED dasatinib, a tyrosine kinase inhibitor, in a transgenic H3.3K27M mutant murine model was assessed. mRNA expression of ABCB1 (p-glycoprotein) was analyzed in 14 tumor types in 274 children. In Vitro viability studies of dasatinib, the p-glycoprotein inhibitor, tariquidar, and dexamethasone were performed in 2 H3.3K27M mutant cell lines. Magnetic resonance imaging (MRI) was used to evaluate CED infusate (gadolinium/dasatinib) distribution in animals pretreated with tariquidar and dexamethasone. Histological assessment of apoptosis was performed.

RESULTS
Continuous delivery CED dasatinib improved median overall survival (OS) of animals harboring DIPG in comparison to vehicle (39.5 and 28.5 d, respectively; P = .0139). Mean ABCB1 expression was highest in K27M gliomas. In Vitro, the addition of tariquidar and dexamethasone further enhanced the efficacy of dasatinib (P < .001). In Vivo, MRI demonstrated no difference in infusion dispersion between animals pretreated with dexamethasone plus tariquidar prior to CED dasatinib compared to the CED dasatinib. However, tumor apoptosis was the highest in the pretreatment group (P < .001). Correspondingly, median OS was longer in the pretreatment group (49 d) than the dasatinib alone group (39 d) and no treatment controls (31.5 d, P = .0305).

CONCLUSION
ABC transporter inhibition plus dexamethasone enhances the efficacy of CED dasatinib, resulting in enhanced tumor cellular apoptosis and improved survival in H3.3K27M mutant DIPG.
Observation of acoustic spin
Authors: Shi Chengzhi , Zhao Rongkuo , Long Yang , Yang Sui , Wang Yuan , Chen Hong , Ren Jie , Zhang Xiang 
Published: May 2019

ABSTRACT
Unlike optical waves, acoustic waves in fluids are described by scalar pressure fields, and therefore are considered spinless. Here, we demonstrate experimentally the existence of spin in acoustics. In the interference of two acoustic waves propagating perpendicularly to each other, we observed the spin angular momentum in free space as a result of the rotation of local particle velocity. We successfully measured the acoustic spin, and spin-induced torque acting on a designed lossy acoustic probe that results from absorption of the spin angular momentum. The acoustic spin is also observed in the evanescent field of a guided mode traveling along a metamaterial waveguide. We found spin–momentum locking in acoustic waves whose propagation direction is determined by the sign of spin. The observed acoustic spin could open a new door in acoustics and its applications for the control of wave propagation and particle rotation.
Impact of Availability of Telehealth Programs on Documented HIV Viral Suppression: A Cluster-Randomized Program Evaluation in the Veterans Health Administration
Authors: Ohl Michael E , Richardson Kelly , Rodriguez-Barradas Maria C , Bedimo Roger , Marconi Vincent , Morano Jamie P , Jones Michael P , Vaughan-Sarrazin Mary 
Published: May 2019

Abstract

Background
Telehealth may improve care for people with HIV who live far from HIV specialty clinics. We conducted a cluster-randomized evaluation to determine the impact of availability of HIV telehealth programs on documented viral suppression in Veterans Administration clinics.

Methods
In 2015–2016, people who previously traveled to HIV specialty clinics were offered telehealth visits in nearby primary care clinics. Patients were cluster-randomized to immediate telehealth availability (n = 925 patients in service areas of 13 primary care clinics offering telehealth) or availability 1 year later (n = 745 patients in 12 clinics). Measures during the evaluation year included telehealth use among patients in areas where telehealth was available and documented HIV viral suppression (viral load performed and &lt;200 copies/mL). Impact of telehealth availability was determined using intention-to-treat (ITT) analyses that compared outcomes for patients in areas where telehealth was available with outcomes for patients where telehealth was not available, regardless of telehealth use. Complier average causal effects (CACEs) compared outcomes for telehealth users with outcomes for control patients with equal propensity to use telehealth, when available.

Results
Overall, 120 (13.0%) patients utilized telehealth when it was available. Availability of telehealth programs led to small improvements in viral suppression in ITT analyses (78.3% vs 74.1%; relative risk [RR], 1.06; 95% confidence interval [CI], 1.01 to 1.11) and large improvements among telehealth users in CACE analyses (91.5% vs 80.0%; RR, 1.14; 95% CI, 1.01 to 1.30).

Conclusions
Availability of telehealth programs improved documented viral suppression. HIV clinics should offer telehealth visits for patients facing travel burdens.
Assessing Endogenous Pain Inhibition: Test–Retest Reliability of Exercise-Induced Hypoalgesia in Local and Remote Body Parts After Aerobic Cycling
Authors: Gomolka Stefan , Vaegter Henrik Bjarke , Nijs Jo , Meeus Mira , Gajsar Hannah , Hasenbring Monika I , Titze Christina 
Published: May 2019

AbstractObjectiveAcute exercise can trigger a hypoalgesic response (exercise-induced hypoalgesia [EIH]) in healthy subjects. Despite promising application possibilities of EIH in the clinical context, its reliability has not been sufficiently examined. This study therefore investigated the between-session and within-subject test–retest reliability of EIH at local and remote body parts after aerobic cycling at a heart rate–controlled intensity.MethodsThirty healthy adults (15 women) performed 15 minutes of aerobic cycling in two sessions. Pressure pain thresholds (PPTs) were assessed at the leg (local), the back (semilocal), and the hand (remote) before, immediately after, and 15 minutes after exercise. Intraclass correlation coefficients (ICCs) were calculated for absolute and percent changes in PPT from baseline to immediately postexercise, and between-session agreement of EIH responders was examined.ResultsPPTs significantly increased at the leg during both sessions (all P < 0.001) and at the back during session 2 (P < 0.001), indicating EIH. Fair between-session reliability was shown for absolute changes at the leg (ICC = 0.54) and the back (ICC = 0.40), whereas the reliability of percent changes was poor (ICC < 0.33). Reliability at the hand was poor for both absolute and percent changes (ICC < 0.33). Agreement in EIH responders was not significant for EIH at the leg or the back (all P > 0.05).ConclusionsOur results suggest fair test–retest reliability of EIH after aerobic cycling for local and semilocal body parts, but only in men, demonstrating the need for more standardized methodological approaches to improve EIH as a clinical parameter.
Disease activity and patient reported outcome measures in Sjögren’s – what are the best tools to evaluate?
Authors: Seror Raphaèle , Rauz Saaeha , Gosset Marjolaine , Bowman Simon J 
Published: May 2019

Abstract
In primary SS (pSS), clinical features in SS can be divided into two facets: the patient perceived manifestations such as dryness, pain and fatigue, and the systemic manifestations. In the past decades, with efforts made by an international collaboration, consensual clinical indexes were developed for assessing both facets: one patient reported outcome, the EULAR SS Patients Reported Index (ESSPRI), and one activity index for systemic manifestations, the EULAR SS Disease Activity Index (ESSDAI). In addition, objective measures were developed to quantify the importance and consequence of ocular and oral dryness, few being specific of pSS. Work is ongoing to develop indexes combining all these approaches. Recent changes in the assessment of pSS patients, and the emergence of new targeted therapies, have put a greater emphasis on the design of clinical trials in pSS, and led for the first time to a positive randomized clinical trial.
Drug retention of biological DMARD in rheumatoid arthritis patients: the role of baseline characteristics and disease evolution
Authors: Lauper Kim , Mongin Denis , Alpizar-Rodriguez Deshire , Codreanu Catalin , Iannone Florenzo , Kristianslund Eirik K , Kvien Tore K , Pavelka Karel , Pombo-Suarez Manuel , Santos Maria J , Gabay Cem , Finckh Axel , Courvoisier Delphine S 
Published: May 2019

Abstract

Objective
To examine the association of the evolution in physician-reported and patient-reported outcomes with decision to stop biological DMARDs (bDMARDs) in RA. The contribution of baseline characteristics is well established, but little is known about how the disease evolution influences the decision to discontinue therapy.

Methods
RA patients who initiated a bDMARD treatment from 2009 and with information on date of visit were pooled from seven European RA registers. Each outcome was divided into baseline assessments (capturing the inter-individual differences at drug initiation) and changes from baseline at subsequent visits (capturing the individual evolution). Cox regression models were used to examine their association with drug discontinuation, adjusting for baseline patient and co-therapy characteristics and stratifying by register and calendar year of drug initiation.

Results
A total of 25 077 patients initiated a bDMARDs (18 507 a TNF-inhibitor, 3863 tocilizumab and 2707 abatacept) contributing an amount of 46 456.8 patient-years. Overall, drug discontinuation was most strongly associated with a poor evolution of the DAS28, with a hazard ratio of 1.34 (95% CI 1.29, 1.40), followed by its baseline value. A change of Physician Global Assessment was the next strongest predictor of discontinuation, then the Patient Global Assessment.

Conclusions
The decision to discontinue treatments appears to be mostly influenced by DAS28 and particularly its evolution over time, followed by Physician Global Assessment evolution, suggesting that the decision to stop bDMARDs relies more on the physician’s than on the patient’s global assessment.