bluuebunny/crossref_metadata_2025_split huggingface dataset:
A grounded theory of inspirational coach leadership
Authors: Figgins Sean G. , Smith Matthew J. , Knight Camilla J. , Greenlees Iain A. 
Published: July 2019

The purpose of this study was to develop a grounded theory of the process of inspirational coach leadership in sport. A Straussian grounded theory methodology was used. Semi‐structured interviews and focus groups were conducted with athletes (n = 22) and coaches (n = 15). Data were analyzed through a process of open and axial coding, and theoretical integration. Through the process of analysis, data were broken down into smaller units (concepts), relationships between concepts were identified, and a substantive grounded theory was developed. The grounded theory of inspirational coach leadership was built around the core category of “athlete(s) inspired through changed awareness of their capabilities.” The core category was underpinned by three categories: (a) establishment of mutual trust and respect with athletes, whereby coaches need to establish trust with athletes in order to inspire athletes; (b) conditions under which inspiration has the potential to occur, which highlighted that athletes are inspired in situations where they are vulnerable or ignorant regarding their potential; and (c) coach acts to change athlete's awareness of their capabilities, which denotes the specific behaviors coaches should display to inspire athletes in such conditions. The theory also highlights that a range of contextual factors relating to the coach, athletes, and performance‐environment interact to impact upon the process. The theory predicts that consistency between coach behavior and the conditions in which inspiration can occur will lead to athlete inspiration, but only if the coach has established a foundation of trust and respect with the athlete.
The role of antenatal and postnatal maternal bonding in infant development: A systematic review and meta‐analysis
Authors: Le Bas Genevieve A. , Youssef George J. , Macdonald Jacqui A. , Rossen Larissa , Teague Samantha J. , Kothe Emily J. , McIntosh Jennifer E. , Olsson Craig A. , Hutchinson Delyse M. 
Published: July 2019

AbstractThe purpose of this study was to systematically review the empirical literature on maternal bonding and associations with infant physical, psychological, and social development. Nineteen articles met inclusion criteria and were included in a qualitative synthesis (79 effect sizes); 15 articles were suitable for aggregation in a series of 14 meta‐analyses (51 effect sizes). All mean effects were in the expected direction, with higher maternal bonding contributing to infant developmental outcomes, including higher attachment quality (r = .35) and parent‐reported lower colic rating (r = .22), easier temperament (r = .19), and positive infant mood (r = .27). Consistent with theoretical explanatory models, the review provides support for the hypothesis that maternal bonding plays a role in fostering more optimal infant development. The review also identifies a paucity of empirical work on this topic and provides directions for future research.
Solidarities from Below in the Making of Emancipatory Rural Politics: Insights from Food Sovereignty Struggles in the Basque Country
Authors: Calvário Rita , Desmarais Annette Aurélie , Azkarraga Joseba 
Published: July 2019

AbstractExclusionary and regressive politics are on the rise globally. How do food sovereignty struggles help counter these forces? We ground our analysis on how EHNE‐Bizkaia, a Vía Campesina member organisation in the Basque Country, conceptualises and practices food sovereignty. Inspired by Massey’s ‘politics of place beyond place’ and Featherstone’s work on left politics and solidarity, we shed light on the ways that this organisation mobilises food sovereignty to establish political bonds between those marginalised by neo‐liberalism, helping to construct political identities and enact forms of subaltern agency that challenge uneven power relations and geographies. We argue that ‘solidarity from below’ is key in building an emancipatory rural politics rooted in class‐based alliances, intersectionality, and internationalism as well as non‐exclusionary notions of sovereignty. The article provides theoretical and empirical insights on what constitutes an emancipatory politics of food sovereignty that has the potential to act as a counterforce to right‐wing populism.
High incidence of drug‐resistant Mycobacterium tuberculosis in Hainan Island, China
Authors: Lin Mingguan , Zhong Yeteng , Chen Zhuolin , Lin Chong , Pei Hua , Shu Wei , Pang Yu 
Published: July 2019

AbstractObjectivesTo assess the proportion of drug‐resistant tuberculosis (TB) cases and to identify independent risk factors associated with drug‐resistant TB in Hainan.MethodsDescriptive analysis of demographic and clinical data of culture‐positive TB patients to assess the trends in drug‐resistant TB at the Provincial Clinical Center on Tuberculosis of Hainan between 2014 and 2017.Results994 patients were recruited into the study. Overall, the proportion of patients resistant to at least one TB drug tested was 36.1% (359/994). The most frequent resistance was to isoniazid (INH, 29.8%), followed by rifampin (RIF, 29.3%), streptomycin (19.3%), ofloxacin (OFX, 17.4%), ethambutol (9.5%) and kanamycin (KAN, 3.2%). Of 291 RIF‐resistant isolates, 228 (78.4%) were also resistant to INH, while the remaining 63 (21.6%) were susceptible to INH. Among those with multidrug‐resistant tuberculosis (MDR‐TB), 41.2% had additional resistance to OFX and 3.9% to KAN. 8.8% of MDR‐TB patients were affected by extensively drug‐resistant (XDR‐TB). Females were more likely to infected with MDR‐TB than males, and young people (<20 years old) were more likely to have MDR‐TB; patients exhibited decreasing MDR‐TB risk with increasing age.ConclusionsOur data provide the first primary understanding of the drug‐resistant TB epidemic in Hainan. The high incidence of drug resistance, especially RIF and FQ resistance, highlight the importance of interventions for preventing epidemics of drug‐resistant TB. Younger age is an independent predictor of MDR‐TB, reflecting the potential transmission in this population.
The mitochondrial NAD+ transporter (NDT1) plays important roles in cellular NAD+ homeostasis in Arabidopsis thaliana
Authors: de Souza Chaves Izabel , Feitosa-Araújo Elias , Florian Alexandra , Medeiros David B. , da Fonseca‐Pereira Paula , Charton Lennart , Heyneke Elmien , Apfata Jorge A.C. , Pires Marcel V. , Mettler‐Altmann Tabea , Araújo Wagner L. , Neuhaus H. Ekkehard , Palmieri Ferdinando , Obata Toshihiro , Weber Andreas P.M. , Linka Nicole , Fernie Alisdair R. , Nunes‐Nesi Adriano 
Published: July 2019

SummaryNicotinamide adenine dinucleotide (NAD+) is an essential coenzyme required for all living organisms. In eukaryotic cells, the final step of NAD+ biosynthesis is exclusively cytosolic. Hence, NAD+ must be imported into organelles to support their metabolic functions. Three NAD+ transporters belonging to the mitochondrial carrier family (MCF) have been biochemically characterized in plants. AtNDT1 (At2g47490), focus of the current study, AtNDT2 (At1g25380), targeted to the inner mitochondrial membrane, and AtPXN (At2g39970), located in the peroxisomal membrane. Although AtNDT1 was presumed to reside in the chloroplast membrane, subcellular localization experiments with green fluorescent protein (GFP) fusions revealed that AtNDT1 locates exclusively in the mitochondrial membrane in stably transformed Arabidopsis plants. To understand the biological function of AtNDT1 in Arabidopsis, three transgenic lines containing an antisense construct of AtNDT1 under the control of the 35S promoter alongside a T‐DNA insertional line were evaluated. Plants with reduced AtNDT1 expression displayed lower pollen viability, silique length, and higher rate of seed abortion. Furthermore, these plants also exhibited an increased leaf number and leaf area concomitant with higher photosynthetic rates and higher levels of sucrose and starch. Therefore, lower expression of AtNDT1 was associated with enhanced vegetative growth but severe impairment of the reproductive stage. These results are discussed in the context of the mitochondrial localization of AtNDT1 and its important role in the cellular NAD+ homeostasis for both metabolic and developmental processes in plants.
Toxoplasma gondii in edible fishes captured in the Mediterranean basin
Authors: Marino Anna Maria Fausta , Giunta Renato Paolo , Salvaggio Antonio , Castello Annamaria , Alfonzetti Tiziana , Barbagallo Antonio , Aparo Alessandra , Scalzo Fabrizio , Reale Stefano , Buffolano Wilma , Percipalle Maurizio 
Published: July 2019

AbstractThe issue of whether market fish can be involved in the transmission of Toxoplasma gondii in the marine environment is highly debated since toxoplasmosis has been diagnosed frequently in cetaceans stranded along the Mediterranean coastlines in recent times. To support the hypothesis that fishes can harbour and effectively transmit the parasite to top‐of‐the‐food‐chain marine organisms and to human consumers of fishery products, a total of 1,293 fishes from 17 species obtained from wholesale and local fish markets were examined for T. gondii DNA. Real‐time PCR was performed in samples obtained by separately pooling intestines, gills and skin/muscles collected from each fish species. Thirty‐two out of 147 pooled samples from 12 different fish species were found contaminated with T. gondii DNA that was detected in 16 samples of skin/muscle and in 11 samples of both intestine and gills. Quantitative analysis of amplified DNA performed by both real‐time PCR and digital PCR (dPCR) confirmed that positive fish samples were contaminated with Toxoplasma genomic DNA to an extent of 6.10 × 10−2 to 2.77 × 104 copies/ml (quantitative PCR) and of 1 to 5.7 × 104 copies/ml (dPCR). Fishes are not considered competent biological hosts for T. gondii; nonetheless, they can be contaminated with T. gondii oocysts flowing via freshwater run‐offs (untreated sewage discharges, soil flooding) into the marine environment, thus acting as mechanical carriers. Although the detection of viable and infective T. gondii oocysts was not the objective of this investigation, the results here reported suggest that fish species sold for human consumption can be accidentally involved in the transmission route of the parasite in the marine environment and that the risk of foodborne transmission of toxoplasmosis to fish consumers should be further investigated.
Mechanisms underlying the cross‐talk between heart and cancer
Authors: Brancaccio Mara , Pirozzi Flora , Hirsch Emilio , Ghigo Alessandra 
Published: July 2019

AbstractCardiovascular diseases and cancer remain the leading cause of death worldwide. Despite the fact that these two conditions have long been considered as distinct clinical entities, recent epidemiological and experimental studies suggest that they should be contemplated and treated as co‐morbidities. Heart failure represents nowadays a well‐established complication of cancer, primarily as a consequence of the aggressive use of cardiotoxic anti‐cancer treatments. On the other hand, the provocative idea that heart failure can prime carcinogenesis has started to emerge, though the molecular basis is still to be fully elucidated. This review summarizes the current knowledge on the mechanisms underlying the bidirectional communication between the failing heart and the cancer. We will discuss and/or speculate on the role of molecular mediators released by either the tumour or the heart that can potentially link heart failure and cancer.
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A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources
Authors: Kernik Divya C. , Morotti Stefano , Wu HaoDi , Garg Priyanka , Duff Henry J. , Kurokawa Junko , Jalife José , Wu Joseph C. , Grandi Eleonora , Clancy Colleen E. 
Published: July 2019

Key points
Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) capture patient‐specific genotype–phenotype relationships, as well as cell‐to‐cell variability of cardiac electrical activity
Computational modelling and simulation provide a high throughput approach to reconcile multiple datasets describing physiological variability, and also identify vulnerable parameter regimes
We have developed a whole‐cell model of iPSC‐CMs, composed of single exponential voltage‐dependent gating variable rate constants, parameterized to fit experimental iPSC‐CM outputs
We have utilized experimental data across multiple laboratories to model experimental variability and investigate subcellular phenotypic mechanisms in iPSC‐CMs
This framework links molecular mechanisms to cellular‐level outputs by revealing unique subsets of model parameters linked to known iPSC‐CM phenotypesAbstractThere is a profound need to develop a strategy for predicting patient‐to‐patient vulnerability in the emergence of cardiac arrhythmia. A promising in vitro method to address patient‐specific proclivity to cardiac disease utilizes induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs). A major strength of this approach is that iPSC‐CMs contain donor genetic information and therefore capture patient‐specific genotype–phenotype relationships. A cited detriment of iPSC‐CMs is the cell‐to‐cell variability observed in electrical activity. We postulated, however, that cell‐to‐cell variability may constitute a strength when appropriately utilized in a computational framework to build cell populations that can be employed to identify phenotypic mechanisms and pinpoint key sensitive parameters. Thus, we have exploited variation in experimental data across multiple laboratories to develop a computational framework for investigating subcellular phenotypic mechanisms. We have developed a whole‐cell model of iPSC‐CMs composed of simple model components comprising ion channel models with single exponential voltage‐dependent gating variable rate constants, parameterized to fit experimental iPSC‐CM data for all major ionic currents. By optimizing ionic current model parameters to multiple experimental datasets, we incorporate experimentally‐observed variability in the ionic currents. The resulting population of cellular models predicts robust inter‐subject variability in iPSC‐CMs. This approach links molecular mechanisms to known cellular‐level iPSC‐CM phenotypes, as shown by comparing immature and mature subpopulations of models to analyse the contributing factors underlying each phenotype. In the future, the presented models can be readily expanded to include genetic mutations and pharmacological interventions for studying the mechanisms of rare events, such as arrhythmia triggers.
Liver sympathetic denervation reverses obesity‐induced hepatic steatosis
Authors: Hurr Chansol , Simonyan Hayk , Morgan Donald A. , Rahmouni Kamal , Young Colin N. 
Published: July 2019

Key points
Non‐alcoholic fatty liver disease, characterized in part by elevated liver triglycerides (i.e. hepatic steatosis), is a growing health problem.
In this study, we found that hepatic steatosis is associated with robust hepatic sympathetic overactivity.
Removal of hepatic sympathetic nerves reduced obesity‐induced hepatic steatosis.
Liver sympathetic innervation modulated hepatic lipid acquisition pathways during obesity.
AbstractNon‐alcoholic fatty liver disease (NAFLD) affects 1 in 3 Americans and is a significant risk factor for type II diabetes mellitus, insulin resistance and hepatic carcinoma. Characterized in part by excessive hepatic triglyceride accumulation (i.e. hepatic steatosis), the incidence of NAFLD is increasing – in line with the growing obesity epidemic. The role of the autonomic nervous system in NAFLD remains unclear. Here, we show that chronic hepatic sympathetic overactivity mediates hepatic steatosis. Direct multiunit recordings of hepatic sympathetic nerve activity were obtained in high fat diet and normal chow fed male C57BL/6J mice. To reduce hepatic sympathetic nerve activity we utilized two approaches including pharmacological ablation of the sympathetic nerves and phenol‐based hepatic sympathetic nerve denervation. Diet‐induced NAFLD was associated with a nearly doubled firing rate of the hepatic sympathetic nerves, which was largely due to an increase in efferent nerve traffic. Furthermore, established high fat diet‐induced hepatic steatosis was effectively reduced with pharmacological or phenol‐based removal of the hepatic sympathetic nerves, independent of changes in body weight, caloric intake or adiposity. Ablation of liver sympathetic nerves was also associated with improvements in liver triglyceride accumulation pathways including free fatty acid uptake and de novo lipogenesis. These findings highlight an unrecognized pathogenic link between liver sympathetic outflow and hepatic steatosis and suggest that manipulation of the liver sympathetic nerves may represent a novel therapeutic strategy for NAFLD.
The Early Arabic Liar: The Liar Paradox in the Islamic World from the Mid-Ninth to the Mid-Thirteenth Centuries CE
Authors: Alwishah Ahmed , Sanson David 
Published: July 2019

AbstractWe describe the earliest occurrences of the Liar Paradox in the Arabic
tradition. The early Mutakallimūn claim the Liar Sentence is both true and
false; they also associate the Liar with problems concerning plural
subjects, which is somewhat puzzling. Abharī (1200-1265) ascribes an
unsatisﬁable truth condition to the Liar Sentence—as he puts it, its being
true is the conjunction of its being true and false—and so concludes that
the sentence is not true. Tūsī (1201-1274) argues that self-referential
sen-tences, like the Liar, are not truth-apt, and defends this claim by
appealing to a correspondence theory of truth. Translations of the texts are
provided as an appendix.
How to Understand ʿal yede? Title Pages of Hebrew Private Library Catalogues Printed in the Dutch Republic during the Long 18th Century
Authors: de Wilde Anna E. 
Published: July 2019

Abstract
As a first step towards more research in the field of Jewish private libraries and Hebrew auction catalogues, this zuta focuses on the understudied corpus of 18th-century Hebrew book sales catalogues printed in the Dutch Republic. It is not always clear if these 18th-century catalogues contain collections from private libraries or retail stocks of publishers, printers, or booksellers. In this article I will analyse and compare the title pages of several catalogues, in order to understand the meaning of the phrase ʿal yede in relation to ownership of the catalogued collections.
Thoughts on the Future of Teaching
Authors: Schleicher Andreas 
Published: July 2019

Top school systems select and educate their teaching staff carefully, they provide an environment in which teachers work together to frame good practice, they encourage teachers to grow in their careers; and they have moved on from administrative control and accountability to professional forms of work organisation.
Still, the laws, regulations, structures and institutions on which education policy tends to focus are just like the small visible tip of an iceberg. The reason why it is so hard to move school systems is that there is a much larger invisible part under the waterline. This invisible part is about the interests, beliefs, motivations and fears of the people who are involved in education, parents and teachers included. This is where unexpected collisions occur, because this part of educational reform tends to evade the radar screen of public policy. That is why educational leaders are rarely successful with reform unless they build a shared understanding and collective ownership for change, and unless they build teacher capacity and create the right policy climate, with accountability measures designed to encourage innovation rather than compliance.
The most essential reason why teachers’ ownership of the profession is a must-have rather than an optional extra lies in the pace of change in 21st century school systems. Even the most effective attempts to translate a central curriculum into local classroom practice will drag out over a decade, because it takes so much time to communicate the goals and methods through the different layers of the system and to build them into traditional methods of teacher education. In a fast-changing world, when what and how students need to learn changes so rapidly, such a slow process leads to a widening gap between what students need to learn and what and how teachers teach. The only way to shorten that pipeline is to professionalise teaching, that is to ensure that teachers not only have a deep understanding of the curriculum as a product, but equally with the process of curriculum and instructional design and the pedagogies to enact and enable the ideas behind the curriculum. The challenge is to build on the expertise of the teachers and school leaders and to enlist them in the design of superior policies and practices. Where systems fail to engage teachers in the design of change, teachers will rarely help systems in the implementation of change.
Successful application of CytoSorb® hemadsorption in an immunocompromised teenager with collapsing glomerulopathy, acute respiratory distress syndrome, and sepsis
Authors: Keles Elif , Fidan Kibriya , Yenicesu Idil , Kalkan Gokhan 
Published: July 2019

Objective: CytoSorb® hemadsorption is an adjunctive therapy in order to reduce elevated cytokine levels of interleukin-6, interleukin-1, and tumor necrosis factor alpha. Here we present a successful administration of CytoSorb® hemadsorption in an immunocompromised pediatric patient with collapsing glomerulopathy, acute respiratory distress syndrome, and sepsis. Data sources: Clinical observations of one patient. Study selection: Case report. Data extraction: Data sources are clinical observation during patient management and patient’s medical records if needed. The patient’s consent was obtained prior to the study. Data synthesis: A 17-year-old male with diarrhea was admitted to the hospital and was later found to have elevated creatinine levels and proteinuria. The renal biopsy was consistent with collapsing glomerulopathy and treatment with multi immunosuppressive agents including corticosteroids, mycophenolate mofetil, and rituximab coupled with several courses of hemodialysis and plasmapheresis were administered. During the hospital stay, Stenotrophomonas maltophilia bacteremia from the blood and the catheter cultures were identified. No clinical response was achieved, and patient developed severe sepsis despite antibiotics, intravenous immunoglobulin, and supportive management including albumin, platelet and erythrocyte concentrations, and fresh frozen plasma. CytoSorb® hemadsorption was then added to the ongoing treatment for three consecutive days. Subsequent to CytoSorb® hemadsorption, immediate laboratory and clinical response were observed. Conclusion: This is the successful clinical report of an immunocompromised teenager with collapsing nephropathy, sepsis, and multi-organ dysfunction syndrome treated with a combination of renal replacement therapy and CytoSorb® hemadsorption. The usage of CytoSorb® hemadsorption represents a novel approach to improve survival of the patients with multiple organ dysfunction and sepsis.