bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phonetic interactions in the bilingual production of Galician and Spanish /e/ and /o/
Authors: de la Fuente Iglesias Monica , Perez Castillejo Susana 
Published: February 2019

Aims and objectives/purpose/research questions: This study investigates the cross-linguistic phonetic interactions in the production of closed mid vowels of Galician-Spanish bilinguals in a semi-urban area in Galicia. The research questions were: (1) Do Galician-Spanish bilinguals produce /e/ and /o/ similarly in their two languages? (2) Does language dominance influence whether these sounds are produced more like Spanish or more like Galician? (3) Do age and gender influence the bilingual production of Galician and Spanish /e/ and /o/? Design/methodology/approach: Thirty Galician-Spanish bilinguals from the western coast of Galicia completed a sociolinguistic questionnaire and two reading tasks in both Galician and Spanish. Data and analysis: 4,728 vowels were acoustically analyzed and submitted to several mixed effect statistical models. Findings/conclusions: Bilinguals in this study produce distinct phonetic categories for their four Galician mid vowels, and additionally have created new phonetic categories to accommodate their L2 (Spanish) vowels, resulting in a more crowded mid-vowel phonetic space. Originality: This is the first study to examine closed mid vowel realizations in both Spanish and Galician by bilinguals who maintain a Galician four mid-vowel contrast, and to investigate their complex L1-L2 phonetic interactions. Significance/implications: This study offers new data to examine how early bilinguals organize their phonetic system(s) through cross-linguistic assimilation and dissimilation.
The Roles of Sufi Teachings in Social Movements: An HRD Perspective
Authors: Budhwani Nadir N. , McLean Gary N. 
Published: February 2019

The Problem There is a growing need to explore the role of the centuries-old tradition of Sufism and its teachings which, through social movements, have contributed to, and continue to influence, human resource development (HRD) at various levels—individual, group, organization, community, nation, and international. The Solution To address this need, we present cases of social movements inspired by Sufi teachings in selected parts of the world. We discuss, using literature and personal experiences, links among Sufi teachings, social movements, and HRD, and provide a framework for understanding Sufi teachings within the context of the social movement phenomenon. We end with recommendations for practice and research. The Stakeholders We target broadening the horizons of HRD researchers, practitioners, civil society members, and social movement activists, encouraging them to address long-term changes and collective learning through the quest for unconditional love and liberation, which represent the core of Sufi teachings.
Phagocytosis of monosodium urate crystals by human synoviocytes induces inflammation
Authors: Zamudio-Cuevas Yessica , Fernández-Torres Javier , Martínez-Nava Gabriela Angélica , Martínez-Flores Karina , Ramírez Olvera Adriana , Medina-Luna Daniel , Hernández Pérez Alma Delia , Landa-Solís Carlos , López-Reyes Alberto 
Published: February 2019

Synovial cells play a crucial part in gouty arthritis, with different features for the inflammation within the joint. However, there is no information about how the synoviocytes can mediate the activation of inflammation. We hypothesized that the process of monosodium urate (MSU) crystal uptake alters the inflammatory response of synoviocytes through regulation of unknown mechanisms. Synoviocytes were stimulated with MSU crystals, and the phagocytosis index (PhIx) was evaluated by counting of cells with MSU ingested using polarized light microscopy. Additionally, transmission electron microscopy and flow cytometry were performed. Secretion of cytokines was measured by a panel of immunoassays. Changes in gene expression of hypoxia-inducible factor-1 ( HIF1A), von Hippel-Lindau ( VHL), and vascular endothelial growth factor ( VEGF) were evaluated by quantitative real-time PCR (qRT-PCR). Protein levels were detected by ELISA. MSU crystals induced a time-dependent increase in PhIx and the formation of numerous secretory vesicles and cavities located in the cytoplasm. Culture supernatants of MSU-treated cells had high levels of the cytokines IL-1β, IL-6, IL-8, TNF-α, and MCP-1, and the growth factors NGF and HGF. The decrease in HIF1A gene expression was 0.58-fold, and overexpression of VHL and VEGF genes was 1.98- and 4-fold, respectively, in MSU-treated synoviocytes compared to untreated cells. Additionally, VEGF levels were increased. The identification of phagocytosis of MSU crystals triggering an inflammatory cellular state in synoviocytes suggests a possible mechanism of synovial activation in the pathogenesis of crystal-induced arthritis. Impact statement Gout is distinguished by an inflammatory process that is mediated by phagocytosis of monosodium urate (MSU) crystals in synoviocytes by regulation of unknown mechanisms. Here we suggest that the synovial cells play a crucial role in gouty arthritis by activating inflammation by MSU uptake and increasing the secretion of pro-inflammatory cytokines IL-1β, IL-6, IL-8, TNF-α, MCP-1, and the growth factors NGF and HGF. We discuss some co-existing features in synoviocytes, including anomalous morphologies of the cells, and microvesicle formation, dysregulation in VEGF gene expression. We provide evidence that phagocytosis of MSU crystals triggers an inflammatory cellular state in synoviocytes in the pathogenesis of crystal-induced arthritis.
The great choke, Ovation® aortic body graft stenosis
Authors: Alsheekh Ahmad , Aurshina Afsha , Chait Jesse , Hingorani Anil , Ascher Enrico 
Published: February 2019

Introduction Abdominal endovascular aneurysm repair is a minimally invasive alternative to major open surgery for the repair of abdominal aortic aneurysms that results in reduced recovery times and early survival rates. Methods The TriVascular Ovation® Abdominal Stent Graft System is a low-profile endovascular device with active fixation used for endovascular aneurysm repair. The stent graft is designed to reline the diseased vasculature, providing an endovascular blood conduit for isolating the aneurysm from the high-pressure flow of blood, thereby reducing the risk of rupture. The stent graft is a modular configuration comprised of an aortic body section, iliac limbs, and iliac extensions as required. Results and Conclusion: We present a case of symptomatic aortic body graft stenosis in the unsupported segment below the O-rings, 26 months after the treatment of abdominal aortic aneurysm with Ovation® Abdominal Stent Graft System. The successful repair was performed by ballooning the stenotic area which resulted in complete resolution of the symptoms.
Burden of large vessel occlusion stroke and the service gap of thrombectomy: A population-based study using a territory-wide public hospital system registry
Authors: Tsang Anderson C.O. , You Jia , Li Lai Fung , Tsang Frederick C.P. , Woo Pauline P.S. , Tsui Eva L.H. , Yu Philip , Leung Gilberto K. K. 
Published: February 2019

Background Ischemic stroke due to large vessel occlusion can be effectively treated with thrombectomy but access to this treatment is limited in many parts of the world. Local incidence of large vessel occlusion is critical in determining the development of thrombectomy service, but reliable data from Asian countries are lacking. Aims We performed a population-based study to estimate the burden of large vessel occlusion and the service gap for thrombectomy in Hong Kong. Methods All acute ischemic stroke patients admitted in 2016 to the public healthcare system, which provided 90% of the emergency healthcare in the city, was identified from the Hong Kong Hospital Authority’s central electronic database. The diagnosis of large vessel occlusion was retrospectively verified by two independent cerebrovascular specialists in a randomly sampled cohort based on clinical and neuroimaging data. The incidence of large vessel occlusion in the population was estimated through weighting the sample results and compared with the thrombectomy data in the same period. Results There were 6859 acute ischemic stroke patients treated in the public health system in 2016. Amongst the 300 patients randomly sampled according to diagnosis coding, 130 suffered from anterior circulation large vessel occlusion. This translated to 918 patients (95% CI 653–1180) and 13.3% of all ischemic stroke patients. The estimated incidence of anterior circulation large vessel occlusion was 12.5 per 100,000 persons per year (95% CI 11.7–13.4). Large vessel occlusion stroke patients were more commonly female than male (67.4% vs. 31.6%, p = 0.003), and were older than non-large vessel occlusion stroke patients (mean of 80.5 years vs. 71.4 years, p = < 0.001). They also had higher 30-day mortality rate (31.1% vs. 4.6%, p = < 0.001), and longer hospital stay (mean 38.6 vs. 21.1 days, p = 0.003) than non-large vessel occlusion stroke. In the same period, 83 thrombectomies for large vessel occlusion were performed, representing 9.1% of the estimated large vessel occlusion incidence. Conclusion The estimated incidence of anterior circulation large vessel occlusion in the Hong Kong Chinese population is lower than that in the West. There is however a substantial service gap for endovascular thrombectomy with less than 10% of large vessel occlusion patients receiving thrombectomy.
Impact of calcification and infrapopliteal outflow on the outcome of endovascular treatment of femoropopliteal occlusive disease
Authors: Athayde Soares Rafael de , Matielo Marcelo Fernando , Brochado Neto Francisco Cardoso , Pires Ana Paula Maia , de Almeida Rogério Duque , de Jesus Martins Murilo , Sacilotto Roberto 
Published: February 2019

Objectives In this paper, we report the long-term outcomes of the endovascular treatment of femoropopliteal occlusive disease, focusing on the importance of calcification and runoff outflow on limb salvage and patency, and the factors associated with these outcomes at a single center. Methods This retrospective cohort study included consecutive patients with femoropopliteal occlusive who underwent femoropopliteal angioplasty at the Division of Vascular and Endovascular Surgery, Hospital do Servidor Público Estadual, São Paulo, Brazil, between January 2015 and July 2017. Results In total, 86 femoropopliteal occlusive angioplasties were performed in 86 patients, with an initial technical success rate of 95.34%. The mean ± standard deviation follow-up time was 880 ± 68.84 days. The analysis was performed at 720 days. Technical failure occurred in four patients, who were excluded from the analysis, leaving 82 patients and 82 femoropopliteal occlusive angioplasties. The estimated primary patency, secondary patency, limb salvage, and overall survival rates at 720 days were 60%, 96%, 90%, and 82.5%, respectively. In univariate and multivariate analyses, Cox regression showed worse primary patency rates in patients with one tibial vessel or isolated popliteal artery runoff ( p = 0.005), calcification grade 4 ( p = 0.019), calcification grade > 2 ( p = 0.017), small vessel diameter < 4 mm ( p = 0.03) or primary angioplasty without stenting ( p = 0.021). A univariate analysis showed worse limb salvage in patients with one tibial vessel or isolated popliteal artery runoff ( p = 0.039). Conclusions In this study, the main factors associated with worse outcomes in the endovascular treatment of femoropopliteal occlusive in terms of loss of primary patency were one tibial vessel or isolated popliteal artery runoff, calcification grade 4, or calcification grade > 2, small vessel diameter < 4 mm, and no stents use. One tibial vessel or isolated popliteal artery runoff was also associated with limb loss in a univariate Cox regression analysis.
Involvement of Patient and Family Representatives in Health-Care Job Interview Panels
Authors: Thomsen Thora Grothe , Hølge-Hazelton Bibi 
Published: February 2019

Objectives: The involvement of patient and family representatives in job interview panels is sparsely documented. This study was conducted at a newly established university hospital in Denmark. The aim was to identify different perspectives on attitudes and experiences associated with involving patient and family representatives in the recruitment process for senior staff. Furthermore, the aim was to highlight considerations and reservations related to the subsequent implementation process. Methods: Inspiration was drawn from formative evaluation research. Data Sources: Seventeen telephone interviews with applicants, 49 e-mail responses from staff, and unsolicited e-mails to the researcher. Analysis Strategy: Interpretive description. Results: Learnings from the study showed among other things that the participating staff experienced widespread skepticism before participation in the job interview panels, but their experience in the panels led them to consider the patients’ and families’ input to be beneficial to the entire recruitment process. The considerations and reservations raised were divided into 5 themes. Conclusions: The results provide a relevant starting point to negotiate and refine the aims of collective patient involvement related to a given situation—such as health-care recruitment processes.
Anti-CD117 antibody depletes normal and myelodysplastic syndrome human hematopoietic stem cells in xenografted mice
Authors: Pang Wendy W. , Czechowicz Agnieszka , Logan Aaron C. , Bhardwaj Rashmi , Poyser Jessica , Park Christopher Y. , Weissman Irving L. , Shizuru Judith A. 
Published: February 2019

Abstract
The myelodysplastic syndromes (MDS) represent a group of clonal disorders that result in ineffective hematopoiesis and are associated with an increased risk of transformation into acute leukemia. MDS arises from hematopoietic stem cells (HSCs); therefore, successful elimination of MDS HSCs is an important part of any curative therapy. However, current treatment options, including allogeneic hematopoietic cell transplantation (HCT), often fail to ablate disease-initiating MDS HSCs, and thus have low curative potential and high relapse rates. Here, we demonstrate that human HSCs can be targeted and eliminated by monoclonal antibodies (mAbs) that bind cell-surface CD117 (c-Kit). We show that an anti-human CD117 mAb, SR-1, inhibits normal cord blood and bone marrow HSCs in vitro. Furthermore, SR-1 and clinical-grade humanized anti-human CD117 mAb, AMG 191, deplete normal and MDS HSCs in vivo in xenograft mouse models. Anti-CD117 mAbs also facilitate the engraftment of normal donor human HSCs in MDS xenograft mouse models, restoring normal human hematopoiesis and eradicating aggressive pathologic MDS cells. This study is the first to demonstrate that anti-human CD117 mAbs have potential as novel therapeutics to eradicate MDS HSCs and augment the curative effect of allogeneic HCT for this disease. Moreover, we establish the foundation for use of these antibody agents not only in the treatment of MDS but also for the multitude of other HSC-driven blood and immune disorders for which transplant can be disease-altering.
Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E
Authors: Ma Xuhui , Li Boya , Liu Jie , Fu Yan , Luo Yongzhang 
Published: February 2019

Abstract
Background
Pancreatic cancer is one of the most malignant cancers. The overall 5-year survival rate of its patients is 8%, the lowest among major cancer types. It is very urgent to study the development mechanisms of this cancer and provide potential targets for therapeutics design. Glucose, one of the most essential nutrients, is highly exploited for aerobic glycolysis in tumor cells to provide building blocks. However, the glucose consumption manner in pancreatic cancer cells is unclear. And the mechanism of the substantial metabolic pathway promoting pancreatic cancer development is also unrevealed.

Methods
13C6 glucose was used to trace the glucose carbon flux and detected by mass spectrum. The expressions of PHGDH were determined in cells and pancreatic adenocarcinomas. Knockdown and overexpression were performed to investigate the roles of PHGDH on pancreatic cancer cell proliferation, colony formation and tumor growth. The mechanisms of PHGDH promoting pancreatic cancer development were studied by identifying the interacting proteins and detecting the regulatory functions on translation initiations.

Results
Pancreatic cancer cells PANC-1 consumed large amounts of glucose in the serine and glycine de novo synthesis. Phosphoglycerate dehydrogenase (PHGDH) highly expressed and controlled this pathway. Knockdown of PHGDH significantly attenuated the tumor growth and prolonged the survival of tumor bearing mice. The pancreatic adenocarcinoma patients with low PHGDH expression had better overall survival. Mechanistically, knockdown of PHGDH inhibited cell proliferation and tumorigenesis through disrupting the cell-cell tight junctions and the related proteins expression. Besides catalyzing serine synthesis to activate AKT pathway, PHGDH was found to interact with the translation initiation factors eIF4A1 and eIF4E and facilitated the assembly of the complex eIF4F on 5’ mRNA structure to promote the relevant proteins expression.

Conclusion
Besides catalyzing serine synthesis, PHGDH promotes pancreatic cancer development through enhancing the translation initiations by interacting with eIF4A1 and eIF4E. Inhibiting the interactions of PHGDH/eIF4A1 and PHGDH/eIF4E will provide potential targets for anti-tumor therapeutics development.
RETRACTED ARTICLE: Research on professional talent training technology based on multimedia remote image analysis
Authors: Xu Bin , Li Xiyuan , Liang Hao , Li Yuan 
Published: February 2019

AbstractIn distance vocational education, teachers need to analyze according to the expression status of different students, so as to make corresponding training in training to improve training efficiency. At present, there are certain problems in the remote expression recognition of professional personnel. Based on this, this study analyzes the facial expression image and uses the wavelet transform algorithm to process the face image in complex lighting environment, thus improving the online transmission effect of the image. After that, this study uses orthogonal projection algorithm for face recognition. In addition, this paper enhances LBP features by dividing the original image into four images by wavelet decomposition. At the same time, in order to prevent the over-characteristics from reducing the classification accuracy and real-time calculation, this paper uses the PCA principal component analysis method to select the feature subset with the largest discrimination. Finally, through SVM, this article has done experiments on JAFFE facial expression database. The experimental results show that the proposed method has a significant improvement in the correct rate compared with the traditional LBP feature classification method and can improve the theoretical reference for subsequent related research.
3D finite element coupled analysis model for geotechnical and complex structural problems of historic masonry structures: conservation of Abu Serga church, Cairo, Egypt
Authors: Hemeda Sayed 
Published: February 2019

Abstract
This research presents the damage mechanism of a historical masonry architecture induced by differential settlement based on 3D FE analysis. The purpose of the study was to investigate the behavior fully-saturated soft clays subjected to self-weight loading from an old masonry structure of Abu Serga church which is the oldest church in Egypt dating back to the fifth century A.D and located in old Cairo area in Cairo city. The church gains its high prestige to having been constructed upon the Holy crypt of the Holy Family where they stayed during their sojourn in Egypt. The main objective of the present study is too accurately record and analysis the geotechnical problems and induced structural failure mechanisms observed and calculated in the field, experimental and numerical studies. The land area is also susceptible to floods. Numerical analysis for such geotechnical problems is largely expected to contribute to the conservation of cultural heritages. The present research presents an attempt and pilot study to design the PLAXIS 3D FE model to simulate ground problems, and to distort and analyze the stress of the complex structure of the Abu Serga church, which is loaded on plane level. Plastic modeling or Mohr–Coulomb model in advanced soil was used during the various stages of numerical analysis. Results are recorded and discussed with respect to stress and volumetric behavior of soil. Finally, the study represents the design studies and implementation of the inter-organizational retrofitting intervention and strengthening project for the oldest Coptic church in Egypt.
Understanding and managing cognitive impairment in bipolar disorder in older people
Authors: Rubinsztein Judy S. , Sahakian Barbara J. , O'Brien John T. 
Published: February 2019

SUMMARYBipolar disorder is less prevalent in older people but accounts for 8–10% of psychiatric admissions. Treating and managing bipolar disorder in older people is challenging because of medical comorbidity. We review the cognitive problems observed in older people, explore why these are important and consider current treatment options. There are very few studies examining the cognitive profiles of older people with bipolar disorder and symptomatic depression and mania, and these show significant impairments in executive function. Most studies have focused on cognitive impairment in euthymic older people: as in euthymic adults of working age, significant impairments are observed in tests of attention, memory and executive function/processing speeds. Screening tests are not always helpful in euthymic older people as the impairment can be relatively subtle, and more in-depth neuropsychological testing may be needed to show impairments. Cognitive impairment may be more pronounced in older people with ‘late-onset’ bipolar disorder than in those with ‘early-onset’ disorder. Strategies to address symptomatic cognitive impairment in older people include assertive treatment of the mood disorder, minimising drugs that can adversely affect cognition, optimising physical healthcare and reducing relapse rates.LEARNING OBJECTIVESAfter reading this article you will be able to:
•understand that cognitive impairment in euthymic older people with bipolar disorder is similar to that in working-age adults with the disorder, affecting attention, memory and executive function/processing speeds•recognise that cognitive impairment in older people is likely to be a major determinant of functional outcomes•Implement approaches to treat cognitive impairment in bipolar disorder.DECLARATION OF INTERESTB.J.S. consults for Cambridge Cognition, PEAK (www.peak.net) and Mundipharma.
De-imperializing Gender
Authors: Wedeven Segall Kimberly 
Published: February 2019

Abstract
In Hope and Other Dangerous Pursuits Laila Lalami writes about a clandestine crossing from Morocco to Spain. Within this story she reveals the effects of this crossing on the changing religious beliefs of her two central female characters. While a probing critique notes how she tends to an analysis of the agency of these immigrants, there is little reference by Lalami to their religious identifiers. This is not an omission but a literary strategy suggesting that religious liaisons form venues of challenge and agency in Islamist revivals. Since faith practices are viewed differently by the women, and by the characters that surround them, these gaps illuminate the contradictions between how women view themselves and how others perceive them. Given how stereotypes of religion have emerged out of a history of colonization, these women’s personal journeys reject structures of entrapment and reductionism, resisting essentialist representations of women and Islam in unexpected ways.