bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microvascular pathology of Friedreich cardiomyopathy
Authors: Koeppen A , Sossei A , Travis A , Kleinhenz E , Mazurkiewicz J , Feustel P , Qian J 
Published: September 2019

Nikolaus Friedreich (1877) was aware of heart disease in his patients but thought it was unrelated to the neurological disorder. In 1946, Dorothy Russell considered cardiomyopathy an integral part of Friedreich ataxia (FA). In addition to sparse inflammatory infiltration, sections show fibrosis and capillary hyperplasia. We examined the left ventricular walls of 41 homozygous FA patients aged 10–87 and 21 controls aged 2–69. An antibody to CD34 enabled quantitative capillary profile counts for a comparison with cardiomyocyte counts in the same field. Mean capillary counts in normals were 1926±341/mm2, and the median ratio of capillaries to cardiomyocytes was 1.0 (interquartile range [IQR]: 0.9-1.2). In FA, however, the number of cardiomyocytes/mm2 was less, and the median ratio of capillaries to heart fibers was 2.0 (IQR 1.4-2.4). There was a significant correlation of the higher guanine-adenine-adenine trinucleotide length (shorter allele, GAA1) with the younger age of onset, shorter disease duration, and lower cardiomyocyte counts. The ratio of capillaries to heart fibers was higher in patients with long GAA1 repeat expansions (e.g., 3.31 in GAA1 of 1200). Double-label immunofluorescence for CD34 and S100A4 revealed co-expression in endothelial cells, supporting endothelial-to-mesenchymal transition in the pathogenesis of cardiac fibrosis (supported by Friedreich’s Ataxia Research Alliance).LEARNING OBJECTIVESThe presentation will enable the learner to:1.Describe endothelial-to-mesenchymal transition in the pathogenesis of cardiac fibrosis in Friedreich cardiomyopathy
Non-Perfused Brain and Retino-Dural Hemorrhage
Authors: Auer RN 
Published: September 2019

10 cases of pneumonia causing cardiac arrest and non-perfused brain occurred at ages 40 days-30 months, in a medico-legal setting. In each deceased child, both the pneumonia and non-perfused brain were verified histologically. Upper respiratory infection and mouth-breathing accompanied the pneumonia, with ongoing choking on formula or food in three cases, and vomiting in an additional five cases. In eight of the 10 cases, the pre-terminal event was a quiet respiratory arrest while sleeping, or being carried in the arms. Adrenaline was given up to 7 times during CPR lasting 44±32 minutes, with up to 2 hours CPR and fall in body temp to &lt;32°C. Mean survival was 1.9±1.5 days and heparin was given for organ donation in 3 cases. The lungs showed chronic interstitial pneumonia as described by Katzenstein, with superadded acute bronchiolo-alveolar infiltrates in two cases of aspiration. The court permitted recuts and cellular characterization of the interstitial cells in one case, revealing the infiltrate was ~40% histiocytes, 5% T or B cells, and ~50% vimentin+ mesenchymal cells. All brains showed features of non-perfused brain and retino-dural hemorrhage. The observed features of non-perfused brain were blurring of the gray-white junction, edema, gross friability, histologic pallor, closure of the microcirculation, patchy acidophilic neurons and recent demarcated pan-necrosis, and pituitary infarction in one patient where hypophysis was sampled. Normally, from birth to 30 months, cerebral blood flow increases to 55% of cardiac output, accompanying physical brain growth. Restoration of high cardiac output using adrenaline-CPR means that on resuscitation, re-routing of blood that can no longer go through the non-perfused brain detours through dura, face, scalp, eyes and optic nerve sheaths. The diversion of blood around non-perfused brain results in facial bruising and retino-dural hemorrhage that can be misinterpreted as head trauma, and a common inference of child abuse in the courts. In the present series from Australia, Canada and the USA, outcomes ranged from acquittal to life imprisonment.LEARNING OBJECTIVESThis presentation will enable the learner to:1.Investigate infant deaths including workup for interstitial pneumonia.2.Know cerebral blood flow changes in development, and cranial blood flow dynamics in non-perfused brain.
Mycobacterium chimaera encephalitis following cardiac surgery in three adult immunocompetent patients: first detailed neuropathological report
Authors: Das SK , Lau D , Cooper R , Chen J , Sim VL , McCombe JA , Tyrrell GJ , Bhargavi R , Adam B , Chapman E , Garady C , Antonation K , Ip S , Saxinger L , van Landeghem FKH 
Published: September 2019

Non-tuberculous mycobacterium encephalitis is rare. Since 2013, a global outbreak of Mycobacterium chimaera infection has been attributed to point-source contamination of heater cooler units used in cardiac surgery. Disseminated M. chimaera infection has presented many unique challenges, including non-specific clinical presentations with delays in diagnosis, and a high mortality rate among predominantly immunocompetent adults. Here, we describe three patients with fatal disseminated Mycobacterium chimaera infection showing initially non-specific, progressively worsening neurocognitive decline, including confusion, delirium, depression and apathy. Autopsy revealed widespread granulomatous encephalitis of the cerebrum, brain stem and spinal cord, along with granulomatous chorioretinitis. Cerebral involvement and differentiation between mycobacterial granulomas and microangiopathic changes can be assessed best on MRI with contrast enhancement. The prognosis of M. chimaera encephalitis appears to be very poor, but might be improved by increased awareness of this new syndrome and timely antimicrobial treatment.LEARNING OBJECTIVESThis presentation will enable the learner to:1.Describe the clinical, radiological and neuropathological findings of Mycobacterium chimaera encephalitis2.Be aware of this rare form of encephalitis, and explain its diagnosis, prognosis and management
Absence of age-related neurodegenerative changes during SIV infection and treatment in aged macaques
Authors: Wiley CA , Bissel SJ 
Published: September 2019

The advent of combined antiretroviral therapy (CART) has changed HIV infection from a lethal disease to a chronic infection. CART has substantially mitigated infection-associated immunosuppression, related opportunistic infections and HIV encephalitis, nevertheless a substantial percentage of infected individuals are afflicted with a spectrum of HIV-associated neurological disorders (HAND). As approximately 45% of HIV-infected subjects in developed countries are over the age of 50, it has been hypothesized that infection may exacerbate age related neurodegenerative processes. We used the nonhuman primate SIV infection model to test whether chronic infection of aged primates, with or without CART, is associated with accelerated age-related neurodegeneration. Two dozen aged macaques (average age 18 years at entry 20 years at the end) were divided into two groups, half infected with SICmac251 and the other half not. After 10 months, half of each of these groups were either treated or not with CART and followed for an additional 6 months. We previously reported the clinical and neurobehavioural outcome. Here we compared the molecular and histologic findings in the four groups. Using a broad spectrum of histological markers, we found no evidence in the macaques of neuropathological changes associated with aging in humans. While the number of animals is small and length of infection limited, this study does not support the hypothesis that lentiviral infection or treatment accelerates age-related neurodegenerative changes in the primate brain.LEARNING OBJECTIVESThis presentation will enable the learner to:1.Explore current theories on the pathogenesis of lentiviral-related neuropathology2.Explain limitations of nonhuman primate models of age-related human brain changes
Immunohistochemical markers of reactive skeletal muscle fibres
Authors: Gould PV 
Published: September 2019

Although most patients undergo muscle biopsies to elucidate the cause of muscle symptoms (weakess, cramping, etc.), many muscle biopsies show relatively few specific alterations on routine staining. Immunohistochemical methods for muscle fibre typing and characterisation of inflammatory cell infiltrates are now well established but the value of other markers is less well documented. A preliminary study of other potentially useful immunohistochemical markers revealed that muscle biopsies in our hospital often contain CD56 and/or D2-40 positive myofibres. This study was extended to a series of 32 biopsies from adult patients (age 21–81, 12 males 20 females), 11 of which showed only minor changes on routine examination. Most cases contained CD56 positive mature fibres; D2-40 positive muscle fibres were more common in cases of inflammatory myopathy. Five cases with minor changes on routine examination showed CD56 and D2-40 staining of otherwise unremarkable myofibres, which might represent reactive changes.LEARNING OBJECTIVESThis presentation will enable the learner to:1.Describe patterns of immunohistochemical staining in reactive muscle fibres2.Discuss the underlying physiology of reactive muscle fibres
Isolated, Subtle Neurological Abnormalities in Mild Cognitive Impairment Types
Authors: Camarda Cecilia , Camarda Rosolino , Pipia Carmela , Azzarello Delia , Grassedonio Emanuele , Sottile Gianluca , Cilluffo Giovanna , Torelli Paola 
Published: September 2019

ABSTRACT:Background:Isolated, subtle neurological abnormalities (ISNA) are commonly seen in aging and have been related to cerebral small vessel disease (SVD) and subcortical atrophy in neurologically and cognitively healthy aging subjects.Objective:To investigate the frequency of ISNA in different mild cognitive impairment (MCI) types and to evaluate for each MCI type, the cross-sectional relation between ISNA and white matter hyperintensities (WMH), lacunes, caudate atrophy, and ventricular enlargement.Methods:One thousand two hundred fifty subjects with different MCI types were included in the analysis and underwent brain magnetic resonance imaging. WMHs were assessed through two visual rating scales. Lacunes were also rated. Atrophy of the caudate nuclei and ventricular enlargement were assessed through the bicaudate ratio (BCr) and the lateral ventricles to brain ratio (LVBr), respectively. Apolipoprotein E (APOE) genotypes were also assessed. The routine neurological examination was used to evaluate ISNAs that were clustered as central-based signs, cerebellar-based signs, and primitive reflexes. The items of Part-III of the Unified Parkinson’s Disease Rating Scale were used to evaluate ISNAs that were clustered as mild parkinsonian signs. Associations of ISNAs with imaging findings were determined through logistic regression analysis.Results:The ISNAs increase with the age and are present in all MCI types, particularly in those multiple domains, and carrying the APOE ϵ4 allele, and are associated with WMH, lacunes, BCr, and LVBr.Conclusion:This study demonstrates that cortical and subcortical vascular and atrophic processes contribute to ISNAs. Long prospective population-based studies are needed to disentangle the role of ISNAs in the conversion from MCI to dementia.
The ConsuMEER study: a randomised trial towards the effectiveness of protein-rich ready-made meals and protein-rich dairy products in increasing protein intake of community-dwelling older adults after switching from self-prepared meals towards ready-made meals
Authors: Borkent Jos W. , Beelen Janne , Linschooten Joost O. , Roodenburg Annet J. C. , de van der Schueren Marian A. E. 
Published: September 2019

AbstractThe risk of undernutrition in older community-dwelling adults increases when they are no longer able to shop or cook themselves. Home-delivered products could then possibly prevent them from becoming undernourished. This single-blind randomised trial tested the effectiveness of home-delivered protein-rich ready-made meals and dairy products in reaching the recommended intake of 1·2 g protein/kg body weight (BW) per d and ≥25 g of protein per meal. Community-dwelling older adults (n 98; mean age 80·4 (sd 6·8) years) switched from self-prepared to home-delivered hot meals and dairy products for 28 d. The intervention group received ready-made meals and dairy products high in protein; the control group received products lower in protein. Dietary intake was measured at baseline, after 2 weeks (T1), and after 4 weeks (T2). Multilevel analyses (providing one combined outcome for T1 and T2) and logistic regressions were performed. Average baseline protein intake was 1·09 (se 0·05) g protein/kg BW per d in the intervention group and 0·99 (se 0·05) g protein/kg BW per d in the control group. During the trial, protein intake of the intervention group was 1·12 (se 0·05) g protein/kg BW per d compared with 0·87 (se 0·03) g protein/kg BW per d in the control group (between-group differences P &lt; 0·05). More participants of the intervention group reached the threshold of ≥25 g protein at dinner compared with the control group (intervention T1: 84·8 %, T2: 88·4 % v. control T1: 42·9 %, T2: 40·5 %; P &lt; 0·05), but not at breakfast and lunch. Our findings suggest that switching from self-prepared meals to ready-made meals carries the risk of a decreasing protein intake, unless extra attention is given to protein-rich choices.
Reanalysis of the US Geological Survey Benchmark Glaciers: long-term insight into climate forcing of glacier mass balance
Authors: O'Neel Shad , McNeil Christopher , Sass Louis C. , Florentine Caitlyn , Baker Emily H. , Peitzsch Erich , McGrath Daniel , Fountain Andrew G. , Fagre Daniel 
Published: September 2019

AbstractMountain glaciers integrate climate processes to provide an unmatched signal of regional climate forcing. However, extracting the climate signal via intercomparison of regional glacier mass-balance records can be problematic when methods for extrapolating and calibrating direct glaciological measurements are mixed or inconsistent. To address this problem, we reanalyzed and compared long-term mass-balance records from the US Geological Survey Benchmark Glaciers. These five glaciers span maritime and continental climate regimes of the western United States and Alaska. Each glacier exhibits cumulative mass loss since the mid-20th century, with average rates ranging from −0.58 to −0.30 m w.e. a−1. We produced a set of solutions using different extrapolation and calibration methods to inform uncertainty estimates, which range from 0.22 to 0.44 m w.e. a−1. Mass losses are primarily driven by increasing summer warming. Continentality exerts a stronger control on mass loss than latitude. Similar to elevation, topographic shading, snow redistribution and glacier surface features often exert important mass-balance controls. The reanalysis underscores the value of geodetic calibration to resolve mass-balance magnitude, as well as the irreplaceable value of direct measurements in contributing to the process-based understanding of glacier mass balance.
Potential flow over a submerged rectangular obstacle: Consequences for initiation of boulder motion
Authors: HERTERICH J. G. , DIAS F. 
Published: September 2019

AbstractSteady two-dimensional fluid flow over an obstacle is solved using complex variable methods. We consider the cases of rectangular obstacles, such as large boulders, submerged in a potential flow. These may arise in geophysics, marine and civil engineering. Our models are applicable to initiation of motion that may result in subsequent transport. The local flow depends on the obstacle shape, slowing down in confining corners and speeding up in expanding corners. The flow generates hydrodynamic forces, drag and lift, and their associated moments, which differ around each face. Our model replaces the need for ill-defined drag and lift coefficients with geometry-dependent functions. We predict smaller flow velocities to initiate motion. We show how a joint-bound boulder can be transported against gravity, and analyse the influence of a wake region behind an isolated boulder.
Influence of Biogenic Organics on the Chemical Composition of Arctic Aerosols
Authors: Choi J. H. , Jang E. , Yoon Y. J. , Park J. Y. , Kim T.‐W. , Becagli S. , Caiazzo L. , Cappelletti D. , Krejci R. , Eleftheriadis K. , Park K.‐T. , Jang K. S. 
Published: September 2019

AbstractWe use an ultrahigh‐resolution 15‐T Fourier transform ion cyclotron resonance mass spectrometer to elucidate the compositional changes in Arctic organic aerosols collected at Ny‐Ålesund, Svalbard, in May 2015. The Fourier transform ion cyclotron resonance mass spectrometer analysis of airborne organic matter provided information on the molecular compositions of aerosol particles collected during the Arctic spring period. The air mass transport history, combined with satellite‐derived geographical information and chlorophyll concentration data, revealed that the molecular compositions of organic aerosols drastically differed depending on the origin of the potential source region. The protein and lignin compound populations contributed more than 70% of the total intensity of assigned molecules when the air masses mainly passed over the ocean region. Interestingly, the intensity of microbe‐derived organics (protein and carbohydrate compounds) was positively correlated with the air mass exposure to phytoplankton biomass proxied as chlorophyll. Furthermore, the intensities of lignin and unsaturated hydrocarbon compounds, typically derived from terrestrial vegetation, increased with an increase in the advection time of the air mass over the ocean domain. These results suggest that the accumulation of dissolved biogenic organics in the Arctic Ocean possibly derived from both phytoplankton and terrestrial vegetation could significantly influence the chemical properties of Arctic organic aerosols during a productive spring period. The interpretation of molecular changes in organic aerosols using an ultrahigh‐resolution mass spectrometer could provide deep insight for understanding organic aerosols in the atmosphere over the Arctic and the relationship of organic aerosols with biogeochemical processes in terms of aerosol formation and environmental changes.
Warm Events Induce Loss of Resilience in Organic Carbon Production in the Northeast Pacific Ocean
Authors: Bif Mariana B. , Siqueira Leo , Hansell Dennis A. 
Published: September 2019

AbstractBetween 2013 and 2016, a series of warm events induced by ocean atmosphere oscillations negatively impacted productivity in the northeast Pacific Ocean. For two consecutive winters (2013–2014 and 2014–2015), suppressed wind stress and warm near‐surface ocean temperature anomalies restricted vertical mixing between the surface and underlying nutrient‐enriched waters. Here we assess historical data of sea surface temperature and sea level pressure, along with nearly a decade of biogeochemical float data to evaluate the impact of these warm events on organic carbon production. The first stratified winter experienced little apparent impact on the magnitude of net organic carbon production in the growing season relative to prior years, suggesting an immediate resilience from reduced new nutrients, apparently depending on recycled iron. However, the subsequent winter experienced virtually zero net production; a loss of resilience, perhaps due to net iron removal with export, was evident. We find that consistently enhanced winter stratification decreased carbon production much more so than a single warm winter. This study highlights the sensitivity of marine productivity to ocean atmosphere oscillations, reducing deep ocean carbon sequestration with prolonged ocean warming and stratification.
The Generic Mapping Tools Version 6
Authors: Wessel P. , Luis J. F. , Uieda L. , Scharroo R. , Wobbe F. , Smith W. H. F. , Tian D. 
Published: September 2019

AbstractThe Generic Mapping Tools (GMT) software is ubiquitous in the Earth and ocean sciences. As a cross‐platform tool producing high‐quality maps and figures, it is used by tens of thousands of scientists around the world. The basic syntax of GMT scripts has evolved very slowly since the 1990s, despite the fact that GMT is generally perceived to have a steep learning curve with many pitfalls for beginners and experienced users alike. Reducing these pitfalls means changing the interface, which would break compatibility with thousands of existing scripts. With the latest GMT version 6, we solve this conundrum by introducing a new “modern mode” to complement the interface used in previous versions, which GMT 6 now calls “classic mode.” GMT 6 defaults to classic mode and thus is a recommended upgrade for all GMT 5 users. Nonetheless, new users should take advantage of modern mode to make shorter scripts, quickly access commonly used global data sets, and take full advantage of the new tools to draw subplots, place insets, and create animations.
The Midlatitude Thermospheric Dynamics From an Interhemispheric Perspective
Authors: Wu Qian , Sheng Cheng , Wang Wenbin , Noto John , Kerr Robert , McCarthy Michael , Huang Cong , Zhang Xiaoxin , Sarris Theodoros 
Published: September 2019

AbstractUsing Fabry‐Perot interferometers at five midlatitude stations (Boulder, Palmer, Millstone Hill, Mount John, and Kelan) in both hemispheres, we examine the interhemispheric and seasonal variations of midlatitude thermospheric dynamics. We also use the National Center for Atmospheric Research Thermosphere Ionosphere Electrodynamics General Circulation Model (TIEGCM) to simulate the seasonal changes of winds and the effects from Sub‐Auroral Polarization Streams. The observations and TIEGCM simulations show a clear seasonal variation with more westward and equatorward summer winds. The TIEGCM runs overestimate the westward zonal winds and underestimate the electron densities in the northern summer. We believe that the underestimated TIEGCM electron density leads to a weak ion drag effect in the model, and strong westward zonal winds. TIEGCM overestimates the Sub‐Auroral Polarization Stream effects on neutral winds in most cases, probably because the empirical Sub‐Auroral Polarization Stream model used by the TIEGCM applies an unrealistic persistent electric field for a long period of time (over 3 hr) due to the low temporal resolution of the Kp index.
Comment on “A New One‐Equation Model of Fluid Drag for Irregularly Shaped Particles Valid Over a Wide Range of Reynolds Number” by F. Dioguardi et al.
Authors: Bagheri G. , Bonadonna C. 
Published: September 2019

AbstractWith this comment we want to clarify a number of aspects of the paper recently published by Dioguardi, Mele, and Dellino “A New One‐Equation Model of Fluid Drag for Irregularly Shaped Particles Valid Over a Wide Range of Reynolds Number” (hereafter referred to as DMD2018). In particular, we show that contrary to the conclusions of DMD2018, the model of Bagheri and Bonadonna (2016, https://doi.org/10.1016/j.powtec.2016.06.015), hereafter referred to as BB2016, is the best model in predicting the drag and terminal velocity of particles measured by DMD2018, as demonstrated here by comparison of estimation errors. The discrepancy is mainly due to a production error (misplaced parentheses) introduced in BB2016 during the publication process and partly due to the incorrect methodology used by DMD2018 to calculate particle terminal velocity. Here we present the correct sets of equations and methodology to show that typo‐free model of BB2016 outperforms all existing drag models including the new model suggested by DMD2018.