bluuebunny/crossref_metadata_2025_split huggingface dataset:
Globalisation: Recent traits and challenges
Authors: Cuadros Ana , Ordóñez Javier 
Published: October 2019

AbstractThis special issue gathers together twelve papers that revisit a range of core topics in the field of international economics. These papers were presented at the XIX Conference on International Economics (CIE) held in Vila‐Real (Spain) on 28th–29th June 2018. The Conference was co‐organized by researchers from the Spanish Association of International Economics and Finance (AEEFI) and the Institute of International Economics (IEI). The selected papers are stimulating pieces that shed new light on recent trends in globalization as well as some of the main challenges that need to be faced in the presence of the multiple yield curves that emerged after the credit crunch. The CIE also included two keynote lectures by Laura Alfaro (Harvard Business School) and Gabriel Quirós (IMF) as well as 64 selected contributions.
Dermatological topical products used in the US population and their toxicity to dogs and cats
Authors: Tater Kathy Chu , Gwaltney‐Brant Sharon , Wismer Tina 
Published: October 2019

BackgroundMany dermatological topicals are available for human use and may be toxic to dogs and cats. No epidemiological studies have been performed in the US population on the use of dermatological topical prescription drugs, and their toxicosis to dogs and cats.ObjectivesSummarize the variety of dermatological topical prescriptions potentially used by pet owners in the United States (US), and describe the epidemiology of dog and cat exposures and toxicities.Animals/SubjectsA dataset of 10,170 individuals from the National Health and Nutrition Examination Survey (NHANES) representative of 311,065,381 US residents. There were 61,169 dog and cat cases with exposure to dermatological topicals from the American Society for the Prevention of Cruelty to Animals (ASPCA) Animal Poison Control Center (APCC) database.Methods and materialsPrescription medication data were analyzed from NHANES 2011–2014 survey respondents. The APCC database was searched for records of dermatological topical drug cases between January 2001 and January 2018.ResultsPrescription dermatological topical medications were used by 1.33 ± 0.21% of the US population. Dermatological topical products (177, veterinary and human) resulted in 61,169 exposure calls to the APCC. Clinical signs developed in 38% (22,910). A human‐labelled product was involved in 15% (3,463) with 74% (2,545) involving a prescription product.Conclusions and clinical significancePets in households with humans receiving dermatological prescription topicals may be at risk for toxicosis. Multiple human‐labelled dermatological topicals can cause death or major illness to dogs and cats at low dosages. Increased public awareness, especially attention to home storage practices for human‐labelled dermatological topicals, may reduce the risk of exposure and toxicosis to dogs and cats.
Dynamic Multi-Sensor Platform for Efficient Three-Dimensional-Digitalization of Cities
Authors: García-Moreno Angel-Iván 
Published: October 2019

Abstract
Three-dimensional urban reconstruction requires the combination of data from different sensors, such as cameras, inertial systems, GPS, and laser sensors. In this technical report, a complete system for the generation of textured volumetric global maps (deep vision) is presented. Our acquisition platform is terrestrial and moves through different urban environments digitizing them. The report is focused on describing the three main problems identified in this type of works. (1) The acquisition of three-dimensional data with high precision, (2) the extraction of the texture and its correlation with the 3D data, and (3) the generation of the surfaces that describe the components of the urban environment. It also describes the methods implemented to extrinsically calibrate the acquisition platform, as well as the methods developed to eliminate the radial and tangential image distortion; and the subsequent generation of a panoramic image. Procedures are developed for the sampling of 3D data and its smoothing. Subsequently, the process to generate textured global maps with a negligible uncertainty is developed and the results are presented. Finally, the process of surface generation and the post-process of eliminating certain holes/occlusions in the meshes are reported. In each section, results obtained are shown. Using the methods presented here for geometric and photorealistic reconstruction of urban environments, high-quality 3D models are generated. The results achieved the following objectives: generate global textured models that preserve the geometry of the scanned scenes.
Scale and Pose-Invariant Feature Quality Inspection for Freeform Geometries in Additive Manufacturing
Authors: Jin Yu , Pierson Harry , Liao Haitao 
Published: October 2019

Abstract
Additive manufacturing (AM) has the unprecedented ability to create customized, complex, and nonparametric geometry, and it has made this ability accessible to individuals outside of traditional production environments. Geometric inspection technology, however, has yet to adapt to take full advantage of AM’s abilities. Coordinate measuring machines are accurate, but they are also slow, expensive to operate, and inaccessible to many AM users. On the other hand, 3D-scanners provide fast, high-density measurements, but there is a lack of feature-based analysis techniques for point cloud data. There exists a need for developing fast, feature-based geometric inspection techniques that can be implemented by users without specialized training in inspection according to geometric dimensioning and tolerancing conventions. This research proposes a new scale- and pose-invariant quality inspection method based on a novel location-orientation-shape (LOS) distribution derived from point cloud data. The key technique of the new method is to describe the shape and pose of key features via kernel density estimation and detect nonconformities based on statistical divergence. Numerical examples are provided and tests on physical AM builds are conducted to validate the method. The results show that the proposed inspection scheme is able to identify form, position, and orientation defects. The results also demonstrate how datum features can be incorporated into point cloud inspection, that datum features can be complex, nonparametric surfaces, and how the specification of datums can be more intuitive and meaningful, particularly for users without special training.
Resource Allocation for System Reliability Assessment Using Accelerated Life Testing
Authors: Moustafa Kassem , Hu Zhen , Mourelatos Zissimos P. , Baseski Igor , Majcher Monica 
Published: October 2019

Abstract
Accelerated life test (ALT) has been widely used to accelerate the product reliability assessment process by testing a product at higher than nominal stress conditions. For a system with multiple components, the tests can be performed at component-level or system-level. The data at these two levels require different amount of resources to collect and carry different values of information for system reliability assessment. Even though component-level tests are cheap to perform, they cannot account for the correlations between the failure time distributions of different components. While system-level tests can naturally account for the complicated dependence between component failure time distributions, the required testing efforts are much higher than that of component-level tests. This research proposes a novel resource allocation framework for ALT-based system reliability assessment. A physics-informed load model is first employed to bridge the gap between component-level tests and system-level tests. An optimization framework is then developed to effectively allocate testing resources to different types of tests. The information fusion of component-level and system-level tests allows us to accurately estimate the system reliability with a minimized requirement on the testing resources. Results of two numerical examples demonstrate the effectiveness of the proposed framework.
Initiation and evolution of forearc basins in the Central Myanmar Depression
Authors: Cai Fulong , Ding Lin , Zhang Qinghai , Orme Devon A. , Wei Honghong , Li Jinxiang , Zhang Ji’en , Zaw Than , Sein Kyaing 
Published: October 2019

AbstractThe forearc basin in Myanmar is significant in understanding the development of continental forearc basins. We present stratigraphic, sandstone petrographic, and U-Pb detrital data from Upper Cretaceous–Eocene strata of Chindwin and Minbu sub-basins in the Central Myanmar Depression. The Upper Cretaceous lower Kabaw Formation consists of turbiditic conglomerate, sandstone, and mudstone in the Minbu sub-basin. The composition of conglomerates are mainly schist and subordinate quartz. Prominent detrital zircon age probability peaks are between 260 and 223 Ma, similar with that of Upper Triassic Pane Chaung turbidites and Kanpetlet schist on the West Burma plate. In the upper Kabaw Formation, turbiditic volcanic-rich sandstones have major age populations ranging from 103 to 70 Ma in both Minbu and Chindwin sub-basins. The Paleocene slope environment Paunggyi Formation, which overlies the Kabaw Formation, mainly consists of conglomerate, sandstone, mudstone, and tuff beds in the Minbu sub-basin. In contrast, the Paunggyi Formation in the Chindwin sub-basin is composed of sandstone and mudstone; major detrital zircon age populations from the Paunggyi Formation are between 100 and 60 Ma. Eocene strata in both basins are composed mainly of shallow marine to delta sandstone and mudstone. Major detrital zircon age populations are 100–36 Ma and 600–500 Ma. The Late Cretaceous–Eocene ages from Upper Cretaceous–Eocene strata overlap with igneous crystallization ages from the Western Myanmar Arc. We propose that the Chindwin and Minbu sub-basins developed as parts of a forearc basin along the west flank of Western Myanmar Arc (present coordinate). The forearc basin initiated in Albian time atop the continental West Burma plate due to the formation of a structural high along the western margin of West Burma plate.
Low total cholesterol is associated with increased major adverse cardiovascular events in men aged ≥70 years not taking statins
Authors: Gnanenthiran Sonali Rukshana , Ng Austin C C , Cumming Robert , Brieger David B , Le Couteur David , Waite Louise , Handelsman David , Naganathan Vasi , Kritharides Leonard , Blyth Fiona 
Published: October 2019

ObjectiveLow levels of total cholesterol (TC) are associated with adverse outcomes in older populations. Whether this phenomenon is independent of statin use is unknown. We investigated the association between low TC levels and long-term major adverse cardiovascular events (MACE) in a prospective study of men aged ≥70 years without ischaemic heart disease (IHD) and whether this was influenced by statin use.MethodsThe CHAMP (Concord Health and Ageing in Men Project) cohort is a prospective cohort study of community-dwelling men aged ≥70 years. The relationship between TC and long-term MACE was analysed using Cox-regression modelling adjusted for comorbidities and stratified by statin use.ResultsThe study cohort comprised 1289 men (mean (±SD) age, 77.0±5.5 years; mean follow-up, 6.4±2.7 years). Decreasing TC level was associated with increased comorbidity burden, frailty and MACE (linear trend p<0.001). In men not on statin therapy (n=731), each 1 mmol/L decrease in TC was associated with increased MACE (HR 1.27, 95% CI 1.10 to 1.45, p=0.001) and mortality (HR 1.22, 95% CI 1.03 to 1.44, p=0.02) adjusted for comorbidities. In contrast, low TC in men on statins (n=558) was not associated with MACE (HR 0.91, 95% CI 0.74 to 1.11) or mortality (HR 0.86, 95% CI 0.68 to 1.09).ConclusionLow TC is associated with increased risk of MACE in older men without IHD who are not taking statin therapy but not in those on statins.
Postanaesthetic effects of ketamine–midazolam and ketamine–medetomidine on gastrointestinal transit time in rabbits anaesthetised with isoflurane
Authors: Botman Julie , Hontoir Fanny , Gustin Pascal , Cambier Carole , Gabriel Fabien , Dugdale Alex , Vandeweerd Jean‐Michel 
Published: October 2019

BackgroundGastrointestinal stasis is a common perianaesthetic complication in rabbits. The objective of this study was to assess the impact on gastrointestinal transit time of ketamine–midazolam (KMZ) versus ketamine–medetomidine (later antagonised by atipamezole) (KMT‐A) in rabbits anaesthetised with isoflurane.MethodsThis was a cross‐over, randomised, single‐blinded, controlled, experimental trial. Seven healthy adult New Zealand White rabbits were used. Gastrointestinal transit time was assessed by contrast radiography in awake rabbits. Presence of contrast medium in the small intestine (gastric transit time), in the caecum (small intestinal transit time) and in faeces in the colon was assessed. One week later, 55 minutes isoflurane anaesthesia was induced with ketamine (15 mg/kg) and either midazolam (3 mg/kg) or medetomidine (0.25 mg/kg) by intramuscular injection. Thirty minutes after discontinuation of isoflurane, atipamezole (0.5 mg/kg) was administered only to rabbits in KMT‐A treatment. Gastrointestinal transit time was then assessed in both treatment groups, beginning 30 minutes after cessation of isoflurane administration. Two weeks later, the treatment groups were interchanged.ResultsGastric and small intestinal transit times were significantly longer with KMT‐A (92±109 minutes and 214±119 minutes, respectively) than with KMZ (1±0 minutes and 103±6 minutes, respectively) and in the awake state (7±7 minutes and 94±32 minutes, respectively).ConclusionClinicians should therefore be aware of the potential gastrointestinal side effects of KMT‐A, particularly in rabbits at risk for gastrointestinal stasis.
Headache Outcomes After Treatment of Unruptured Intracranial Aneurysm
Authors: Dandurand Charlotte , Parhar Harman S. , Naji Faysal , Prakash Swetha , Redekop Gary , Haw Charles S. , Prisman Eitan , Gooderham Peter A. 
Published: October 2019

Background and Purpose—
While unruptured intracranial aneurysms may be discovered incidentally in the workup of chronic headache, it remains unclear whether their treatment ultimately impacts headache severity. We aim to conduct a systematic review and meta-analysis assessing headache severity after treatment of unruptured intracranial aneurysm.

Methods—
MEDLINE and EMBASE were systematically reviewed.

Results—
Data from 7 studies met inclusion criteria (309 nonduplicated patients). The standard mean difference in pre- and post-intervention headache severity was estimated at −0.448 (95% CI, −0.566 to −0.329) under a random effects model. No significant heterogeneity was noted nor was any significant publication bias demonstrated.

Conclusions—
This is the first systematic review assessing postoperative headache severity following treatment of unruptured intracranial aneurysm. While a significant reduction in headache severity was observed, further investigation into this phenomenon is recommended before it influences clinical practice. Future study should stratify headache outcomes by aneurysm size, location, and treatment modality.
GENDER INEQUALITY IN LABOR FORCE PARTICIPATION IN TURKEY: CLOSING THE GENDER GAP?
Authors: İNCE YENİLMEZ Meltem 
Published: October 2019

The roles and status of women have been discovered to be lagging behind in developing countries, especially when it comes to distribution of resources. Why? You may ask. The answer is not far-fetched. The cultural and demographic values developed overtime, as well as the practice of having a social system that is run by males rather than females, are a few reasons for this. Owing to the fact that the existing socio-cultural environment goes a long way to determine how things are accorded to both genders both in the home front, as well as in the labor market, it is not surprising to find women in Turkey lagging behind in many aspects. The purpose of this study is to observe and understand the inherent relationship between female unemployment and economic inequality with regards to the social and demographic norms surrounding the female gender in Turkey. In addition, reducing informal employment, promoting high quality and productive jobs are crucial for addressing the problems of female unemployment.
Social and Economic Impact Analysis of Vadinar Refinery of Essar Oil: The Case of a Mega Refinery
Authors: Chaudhuri Sumana , Ray Shovan 
Published: October 2019

The article is a case study on Essar Oil’s Vadinar Refinery in Gujarat. In the wake of the decision to divest the stake to Rosneft group of Russia, the Ruia’s-led Essar Group were interested to present a portrayal of the financial profitability and socio-economic importance of their refinery project at Vadinar. The project was assigned to the authors towards evaluation. The analysis assumes significance as refinery is a strategic sector, and there lies immense potential for Indian refiners to attain sustainable competitive advantage through economies of scale and adoption of most advanced technologies to process sour crude of the highest complexity, thus, producing the cleanest fuels in multiple distillates. Using a social cost–benefit approach, the article evaluates the financial viability and socio-economic contribution of the refinery at Vadinar at the local and regional level, focusing on multiplier effect of income, tax and savings generated, including other externalities. The present findings would assist in policy implications for the strategic investment in refinery operations as well as building a template for future researchers interested to explore the economic aspect of oil refineries from welfare perspective. JEL: B41, D60, D61, D62, H23, H43, L71, O22, Q43
Canal occlusion in cemented primary total hip replacement: autologous compacted bone block compared to a commercially available gelatine plug
Authors: Agrawal Pranshu , Chacko Vinay J , Divecha Hiren , Board Tim N 
Published: October 2019

Aims: To evaluate the stability of 2 canal occlusion systems; an autologous, compacted bone block and the biodegradable C-plug. We also sought to investigate any relationship between stability of the systems and the quality of cementation. A retrospective radiographic comparative review was conducted. Methods: A total of 203 consecutive patients were analysed, 89 received an autologous bone block and 114 had C-plugs. There was no significant differences between the groups in terms of age, sex and primary diagnosis. The mean cement tail length in the bone block group (6.42 mm; range 0–31) was significantly shorter than in the C-plug group (17.11 mm; range 0–65.7). Results: The proportion of patients with good quality of cementation (Barrack grade A) was significantly higher in the bone block group (80.6%) as compared to the C-plug group (56%) ( p < 0.001). There was a negative correlation between the length of the cement tail and the Barrack grade, indicating that a short cement tail is associated with better quality cementation. Conclusions: We have shown that improved cement penetration and shorter cement tails can be achieved with the cheapest of all options for canal occlusion, an autologous compacted bone block and hence recommend this technique.
Splicing Control in Normal and Aberrant Erythropoiesis
Authors: Obeng Esther 
Published: October 2019

Abstract
Alternative splicing is employed by all eukaryotic cells to increase proteome diversity and to regulate gene expression. RNA sequencing analysis of purified populations of erythroblasts at different stages of maturation has led to the identification of a dynamic alternative splicing program that directly modulates the protein isoform expression of cytoskeletal proteins and genes involved in RNA processing, heme biosynthesis, and iron transport. Regulated interactions of multiple RNA-binding proteins and cis-regulatory sequences located within exons or their flanking introns promote or inhibit functional spliceosome assembly at splice junctions, leading to altered exon inclusion or intron retention. Exon skipping regulates tissue and stage specific isoform expression of red cell membrane cytoskeletal proteins including EPB41, ankyrin, and band 3. Intron retention can lead to a frame shift during translation and introduction of a premature termination codon (PTC), that marks the transcript for degradation via the nonsense mediated decay pathway (NMD) upon export from the nucleus into the cytoplasm. Intron retention leading to posttranscriptional regulation of gene expression during terminal erythroid maturation has been identified in genes involved in RNA processing and iron transport including SF3B1, SNRNP70, SLC25A37 and SLC25A28. Mutations that alter mRNA splice sites or introduce PTCs lead to a variety of congenital anemias including beta thalassemia, hereditary pyropoikilocytosis, hereditary elliptocytosis, and hereditary spherocytosis. Aberrant mRNA splicing has subsequently been shown to lead to acquired anemias in subsets of patients with myelodysplastic syndromes (MDS). Somatic missense mutations in components of the spliceosome are the most common category of mutations in MDS. These point mutations lead to changes in the RNA binding specificity of the involved proteins and aberrant splicing of a subset of transcripts. Mutant SF3B1, the most commonly mutated splicing factor in MDS, has been shown to cause aberrant pre-mRNA splicing and an increase in transcripts predicted to undergo NMD due to use of upstream, cryptic 3' splice sites. Our group and others evaluating the strong genotype-phenotype association between SF3B1 point mutations and subtypes of MDS with ring sideroblasts have shown that the expression of the mitochondrial iron transporter, ABCB7, is decreased in samples from SF3B1-mutant MDS patients due to cryptic 3' splice site selection and introduction of a PTC between exons 8 and 9. The identification and functional validation of additional aberrantly spliced mutant-SF3B1 target genes is ongoing, with the goal of understanding how point mutations in a core component of the mRNA splicing machinery can lead to such specific effects on erythroid maturation.

Disclosures
No relevant conflicts of interest to declare.