bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of e-learning at higher educational institutions in Bangladesh
Authors: Sarker Md Fouad Hossain , Mahmud Rafi Al , Islam M. Saiful , Islam Md Kabirul 
Published: January 2019

Purpose
Although e-learning has already been accepted globally as an effective medium of delivery of quality education and ensure optimum student participation, Bangladeshi higher educational institutions are still at a very early stage of adopting such technologies. Therefore, the purpose of this paper is to critically examine the suitability of implementing effective e-learning through learning management system (LMS) at the tertiary educational institutions in Bangladesh, and how both students and teachers experience and respond to this new learning platform. Following mixed-methods techniques, data for this study were collected from students and respective course teachers of a private university in Bangladesh by administering questionnaires and in-depth interviews. The findings of this paper reveal that e-learning has been well accepted by most of the students as they are found routinely spending time on the LMS on a regular basis for watching lecture videos, viewing course information, reading postings of the fellow students in the forum. However, there are constraints as well, since the learning materials are poorly designed that do not allow much interaction between students and lecturers. There are also some technical problems such as poor internet connection which restrict access to e-learning platforms. To harness the optimum benefit of e-learning, this paper recommends a concerted effort by all stakeholders, such as students, lecturers, administrators and policy makers so that each of their priorities and expectations are reflected in the designing and implementing e-learning platforms.

Design/methodology/approach
This paper is based on the qualitative evaluation of Education 3.0 platform. Primary data were collected from the students using a well-structured survey questionnaire, and the findings of the survey have subsequently been cross-referred and supplemented by non-participatory observations with semi-structured interviews which allowed a better in-depth understanding of the issue at hand.

Findings
The findings of the study suggest that a majority of the students are found to be highly enthusiastic about the online courses. They are eager to participate and interact in the online platforms, which are somehow limited in the traditional classroom settings. However, there are several institutional, administrative and technical limitations of implementing e-learning in Bangladesh. It is recommended that better orientation of the users, quality content distribution though user-friendly systems and enhanced asynchronous interaction between the lecturers and students are the key pre-requisites to harness the optimum benefit from e-learning technologies in Bangladesh.

Originality/value
The data have been analyzed and discussed using qualitative framework which allows an in-depth understanding of the opportunities and challenges of the use of e-learning technologies at the higher educational institutions in Bangladesh.
Feasibility and initial efficacy of project‐based treatment for people with ABI
Authors: Behn Nicholas , Marshall Jane , Togher Leanne , Cruice Madeline 
Published: January 2019

AbstractBackgroundCommunication impairments are common and pervasive for people a long time following acquired brain injury (ABI). These impairments have a significant impact on a person's quality of life (QOL) post‐injury. Project‐based treatment is a treatment approach that could have an impact on communication skills and QOL for people with ABI a long‐term post‐injury. This treatment is embedded in a context of meaningful activities chosen by people with ABI, whereby, as a group, they work collaboratively to achieve a tangible end product.AimsTo evaluate the feasibility and initial efficacy of project‐based treatment on improving the communication skills and QOL for people with ABI.Methods & ProceduresAn exploratory controlled trial with alternate allocation of groups, and follow‐up at 6–8 weeks, was completed. Twenty‐one people with chronic ABI were recruited in groups of two to three from community settings, allocated to either a TREATMENT (n = 11) or WAITLIST group (n = 10). Participants attended a 20‐h group‐based treatment over 6 weeks where they worked towards achieving a project that helped others. To determine feasibility, four criteria were used: demand, implementation, practicality and acceptability. A range of communication and QOL outcomes was used to determine a fifth feasibility criterion, initial efficacy. Some of these criteria were additionally used to evaluate the feasibility of the outcomes.Outcomes & ResultsAll participants received the treatment as allocated with high attendance and no dropouts. The treatment was feasible to deliver as intended and was highly acceptable to participants. Medium and large effect sizes were found from pre‐ to post‐treatment, and from pre‐treatment to follow‐up for measures of conversation, perceived communicative ability and QOL.Conclusions & ImplicationsProject‐based treatment is feasible with indications of initial efficacy for both communication skills and QOL. The treatment provides a promising new approach for improving communication skills and QOL in people with chronic acquired brain injuries in the community setting.
Rule of Law and Rules‐Lawyering: Legal Corruption and ‘Reprivatization Business’ in Warsaw
Authors: Kusiak Joanna 
Published: January 2019

AbstractDelving into the nexus between the state and informality, this paper discusses the informality of the legal and judicial systems. Produced by structurally powerful actors, this kind of informality is not so much legitimized by the law, but concealed within the very process of legitimization. To capture how legal engineering welds formalized laws with informal translations, I look at judicial outcomes that, while formally legal, are socially delegitimized and perceived as legal corruption. After analysing the contested judicial outcomes of Warsaw's ‘reprivatization’ process (property restitution), I define the mechanism of legal corruption as rules‐lawyering, by which I mean an attempt to gain legal advantage by obsessively sticking to the written laws, while deliberately desecrating its spirit. I describe three of its mechanisms: appropriation, redefinition and fraud laundering. Finally, in my preliminary vivisection of the recent and ongoing process of delegalizing the legal corruption that has been part of the reprivatization process, all the allied concepts of this forum come together to demonstrate the essential inseparability of informality and state.
Interlocking Lives: Employment Mobility and Family Fixity in Three Gentrifying Neighbourhoods of Montreal
Authors: High Steven , Goulet Lysiane Gervais , Duchesneau Michelle , Guay‐Bélanger Dany 
Published: January 2019

AbstractThis article explores the relationship between employment mobility, family fixity, and gentrification in the lives of 36 residents in and extended commuters to Montreal's southwest borough. Once described as the birthplace of industry in Canada, the neighbourhoods of Saint‐Henri, Little Burgundy and Point Saint‐Charles have undergone sweeping changes in recent decades. Inner‐city areas are not necessarily where one expects to find mobile workers, but this is changing due to shifting gender roles, the rise of dual‐income households and gentrification. Michael Savage's concept of ‘elective belonging’ proved particularly useful in understanding this connection. With its proximity to childcare, schools, stores and workplaces, the central city permits a more equitable division of labour within the household. Our place‐based approach to mobile work enables us to capture a wide spectrum of experience, ranging from people with extended daily commutes to those whose work takes them away from home for days, weeks or months at a time. Our interviews reveal a connection between employment mobility and family gentrification, as upwardly mobile families find ways to localize other aspects of their lives. The simultaneity of mobility and immobility are often essential, especially in dual‐income households. One parent's mobility often leads to the relative immobility of other family members.
Personal genomic testing for nutrition and wellness in Australia: A content analysis of online information
Authors: Tutty Erin , Hickerton Chriselle , Adamski Melissa M. , Metcalfe Sylvia A. 
Published: January 2019

AimPersonal genomic testing for nutrition and wellness (PGT‐NG) offers a new service delivery model to nutritionists and dietitians. However, research indicates that this type of testing currently lacks sufficient clinical validity and utility to be commercially available. Despite Australian guidelines to the contrary, healthcare professionals are currently offering testing to clients, and promoting these services online. Thus, it is important to understand how PGT‐NG is currently framed online to the public.MethodsA mixed methods content analysis was conducted to assess the content, quality and marketing approaches of websites offering PGT‐NG to Australians. Websites were identified using popular search engines to mimic the behaviour of a consumer. A novel framework was developed for the purposes of the analysis.ResultsThirty‐nine websites were analysed, comprising four nutritional genomic testing company websites and 35 healthcare provider websites. Healthcare providers relied on information from the testing companies. The content was emotive, and little attention was given to the scientific and ethical aspects of personal genomic testing. Websites appealed to consumer empowerment and framed testing as an essential and superior tool for optimising health.ConclusionsWebsites lacked the transparency necessary for informed consent. A basic checklist of key information was developed to aid healthcare providers when informing potential clients of PGT‐NG online.
Brettanomyces Spoilage in Albanian Wines Assessed by Culture‐Dependent and Culture‐Independent Methods
Authors: Lloha Ilir , Peçuli Anisa , Basha Elton , Zejnelhoxha Sanije , Mamoci Erjon , Milanović Vesna , Sabbatini Riccardo , Osimani Andrea , Garofalo Cristiana , Clementi Francesca , Agarbati Alice , Ciani Maurizio , Aquilanti Lucia 
Published: January 2019

AbstractIn the Albanian winemaking industry, there is little awareness of the potential detrimental effect of Brettanomyces in wines. The aim of this study was to detect and quantify Brettanomyces cells in 22 Albanian bottled wines, representing all the viticultural areas of Albania. A combined approach, including culture‐dependent (viable plate counting) and culture‐independent (qPCR) methods, was applied. Spoilage indicators (ethylphenols and total and volatile acidity), as well as the primary factors known to influence the growth of Brettanomyces in wine (pH, SO2, and ethanol concentration), were also investigated. Brettanomyces was detected in only five (one Merlot, four Sheshi i Zi) out of 22 samples analyzed using viable counting, with loads ranging from 1.30 ± 0.03 log CFU/mL to 3.99 ± 0.00 log CFU/mL, whereas it was never detected in the Kallmet samples. When qPCR was applied, Brettanomyces cells were detected and quantified in all of the samples with a generally low load ranging from 0.47 ± 0.13 to 3.99 ± 0.01 log cells/mL. As a general trend, the loads of spoilage by this yeast were low (≤1.92 log cells/mL), with the exception of five samples that were also positive by plate counting. A positive correlation between the growth of this spoilage yeast on Dekkera/Brettanomyces differential media and its detection at high levels by qPCR was observed. A significant positive correlation between Brettanomyces and the concentration of ethylphenols and volatile acidity was also found. In summary, the results of this study demonstrated the low incidence of Brettanomyces spoilage yeasts in Albanian red wines.Practical ApplicationThe awareness of Brettanomyces spoilage in the Albanian winemaking industry is very low. This study represents the first contribution to understand the extent of this spoilage yeast in Albanian autochthonous cultivars, which tend to have high economic value, to ensure product quality and safety. qPCR is confirmed to be a very sensitive method to rapidly detect Brettanomyces spoilage in wine samples.
Predictive performance of a new pharmacokinetic model for propofol in underweight patients during target‐controlled infusion
Authors: Yi Jung‐Min , Doh Il , Lee Seok‐Hwan , Kim Soo‐Young , Lee Yong‐Hun , Lee Eun‐Kyung , Lee Soo‐Han , Choi Byung‐Moon , Noh Gyu‐Jeong 
Published: January 2019

BackgroundIn a previous study, the modified Marsh and Schnider models respectively showed negatively‐ and positively‐biased predictions in underweight patients. To overcome this drawback, we developed a new pharmacokinetic propofol model‐the Choi model‐for use in underweight patients. In the present study, we evaluated the predictive performance of the Choi model.MethodsTwenty underweight patients undergoing elective surgery received propofol via TCI using the Choi model. The target effect‐site concentrations (Ces) of propofol were 2.5, 3, 3.5, 4, 4.5, and 2 μg/mL. Arterial blood samples were obtained at least 10 minutes after achieving pseudo‐steady‐state. Predicted propofol concentrations with the modified Marsh, Schnider, and Eleveld pharmacokinetic models were obtained by simulation (Asan pump, version 2.1.3; Bionet Co. Ltd., Seoul, Korea). The predictive performance of each model was assessed by calculation of four parameters: inaccuracy, divergence, bias, and wobble.ResultsA total of 119 plasma samples were used to determine the predictive performance of the Choi model. Our evaluation showed that the pooled median (95% CI) bias and inaccuracy were 4.0 (−4.2 to 12.2) and 23.9 (17.6‐30.3), respectively. The pooled biases and inaccuracies of the modified Marsh, Schnider, and Eleveld models were clinically acceptable. However, the modified Marsh and Eleveld models consistently produced negatively biased predictions in underweight patients. In particular, the Schnider model showed greater inaccuracy at a target Ce ≥ 3 µg/mL.ConclusionThe new propofol pharmacokinetic model (the Choi model) developed for underweight patient showed adequate performance for clinical use.
Outcome of chemotherapy with or without targeted agents in metastatic colorectal cancer patients with deficient DNA mismatch repair: A single center, cohort study
Authors: Yu Yue , Ying Jianming , Zhang Wen , Li Weihua , Sun Yongkun , Yang Lin , Cui Chengxu , Zeng Yixin , Zhou Aiping 
Published: January 2019

AbstractAimsMetastatic colorectal cancer (mCRC) with deficient DNA mismatch repair (dMMR) is a rare disease accounting only for 4–5% of the whole mCRC and its optimal treatment still remains unclear. We conducted a retrospective study to evaluate the outcome of chemotherapy with or without bevacizumab or cetuximab in this setting.MethodsA total of 729 colorectal cancer patients with dMMR status were screened for eligibility. The Kaplan–Meier method, the log‐rank test and Cox analysis were utilized for survival analyses.ResultsA total of 43 patients met the inclusion criteria and enrolled in the study. The median overall survival (OS) of entire cohort was 21.7 months. Chemotherapy plus bevacizumab group exhibited a tendency of substantially higher overall response rate (ORR) than chemotherapy alone group (63.6% vs. 23.8%, P = 0.053), whereas the ORR between chemotherapy plus cetuximab group and chemotherapy alone group were similar (28.6% vs. 23.8%, P = 1.000). Compared with chemotherapy alone group, bevacizumab combined group achieved a significantly longer progression‐free survival (10.0 months vs. 4.8 months, P = 0.028), whereas cetuximab combined group was not (6.8 months vs. 4.8 months, P = 0.158). Although the median OS seemed to favor bevacizumab combined group, no significant differences were detected between the three arms (33.7, 21.7 and 15.3 months, respectively; P = 0.345). Prognostic analysis showed that primary tumor resection was the positive prognostic factor of OS (hazards ratio: 0.438; P = 0.041).ConclusiondMMR mCRC seems resistant to chemotherapy and cetuximab. Bevacizumab combined therapy shows a sign of potentially favorable outcome in this subtype.
Predictors of survival outcome following radical gastrectomy for gastric cancer
Authors: Lui Su‐Ann , Tan Wee Boon , Tai Bee Choo , Yong Wei Peng , Mu Yar Soe , Ti Thiow Kong , Shabbir Asim , So Jimmy 
Published: January 2019

BackgroundRadical surgery with adjuvant therapy is now the standard treatment for locally advanced gastric cancer. However, the best regimen for adjuvant therapy remains controversial. We aim to determine the predictors of survival outcome of gastric cancer patients who underwent curative surgery with or without adjuvant therapy in our institution.MethodsAll patients who received surgery for gastric cancer from years 2000 to 2015 were studied using a prospective gastric cancer database at the National University Hospital, Singapore.ResultsA total of 405 patients underwent radical gastrectomy with curative intent. Seventy‐eight percent received extended lymphadenectomy (≥D1). R0 resection was achieved in 377 patients (93%) with 30‐day mortality rate of 1.7%. There was no significant difference in the complication rate between D1 and extended lymphadenectomy group. One hundred and forty‐five patients (36%) received adjuvant therapy. With a median follow‐up of 5.9 years, the 5‐year disease‐free survival for stage I to IV patients were 78%, 58%, 27% and 9%, respectively. Among the 141 patients with known recurrences, the first site of recurrence was 38% distant, 24% locoregional, 20% peritoneal and the rest were multiple sites. Stage of disease, adjuvant therapy, extent of lymphadenectomy, post‐operative complication and approach of surgery were independent risk factors for long‐term survival.ConclusionsStage of disease, adjuvant therapy, extent of lymphadenectomy, post‐operative complication and approach of surgery are significant predictors for long‐term survival. Adequate and safe surgery to allow adjuvant therapy should be the goal of all surgeons for our gastric cancer patients.
Myopic shift and lens turbidity following hyperbaric oxygen therapy – a prospective, longitudinal, observational cohort study
Authors: Riedl Philip , Škiljić Dragana , Arnell Per , Wannholt Roger , Zetterberg Madeleine , Andersson Grönlund Marita 
Published: January 2019

AbstractPurposeTo examine visual acuity, refraction and ocular status before, during and after hyperbaric oxygen therapy (HBOT).MethodsTwenty‐nine patients underwent 40 standard protocol HBOT treatments. In all subjects, refraction and best corrected visual acuity were measured at baseline and after ten, 20, 30 and 40 treatments, and at a 12‐week follow‐up. A subgroup (n = 19) were given additional examinations at baseline, after 40 treatments and at follow‐up including measuring central corneal thickness (CCT), corneal curvature, anterior chamber depth, lens thickness, axial length, fundus morphology, blood pressure and intraocular pressure (IOP). Lens colour and opalescence were graded using the Lens Opacities Classification System III (LOCS III).ResultsMyopic shifts [≥0.5 dioptre (D) spherical equivalent (SE)] occurred in 45 (77.6%) eyes. Median refractive changes of −0.75 D SE (right eye; p < 0.001) and −0.66 D SE (left eye; p < 0.001) were observed between pretreatment and treatment end (Wilcoxon signed rank test). Refraction returned to baseline at follow‐up, except for a small persisting change towards myopia, median –0.25 D SE (left eye; p = 0.01). Using the LOCS III, median increases in lens nuclear colour, of 0.6 (right eye; p < 0.001) and 0.7 (left eye; p < 0.001), and opalescence of 0.7 (both eyes; p = 0.01) were found at the last examination. Small reductions were noted in CCT of −6.00 μm (right eye; p = 0.03) and −4.00 μm (left eye; p = 0.03), and IOP of −1.50 mmHg (left eye; p = 0.01).ConclusionsThe transient myopic shift may have been due to lenticular refractive index changes. Reduced lens transparency is a potential consequence of HBOT.
Association of chronic hepatitis B virus infection with age‐related macular degeneration
Authors: Wu Chia‐Min , Su Fu‐Hsiung , Wang Wen‐Chang , Lin Chang‐Ping , Kamiza Abram Bunya , Chang Shih‐Ni , Yeh Chih‐Ching 
Published: January 2019

AbstractPurposeTo study the association between chronic hepatitis B virus (HBV) and age‐related macular degeneration (AMD).MethodsData used in this retrospective, frequency‐matched cohort study were acquired from the Longitudinal Health Insurance Database 2000, which includes medical claims and registration files for 1 000 000 enrolees in the Taiwan National Health Insurance programme. The HBV cohort contained 17 796 patients who received a diagnosis of chronic HBV infection between January 1, 2000 and December 31, 2012. The non‐HBV cohort contained 71 184 participants who were frequency‐matched by age, sex and year of index date for comparison. Participants were followed until the end of 2013, and those who developed AMD during the study period were identified. A Cox proportional hazards regression model was used to compare the risk of AMD between cohorts.ResultsThe incidence of any type of AMD in all participants was 3.88 per 1000 person‐years (PY; 2.27 per 1000 PY in the HBV cohort; 1.61 per 1000 PY in the non‐HBV cohort). Compared with the non‐HBV cohort, the adjusted hazard ratio (HR) for any type of AMD in the HBV cohort was 1.41 [95% confidence interval (CI) 1.23–1.63; p < 0.001]. This significant positive association was stronger among patients who exhibited disease progression from nonexudative to exudative AMD (adjusted HR = 1.74, 95% CI: 1.01–2.99).ConclusionOur results suggest that patients with chronic HBV infection in Taiwan have a significantly elevated risk of developing any type of AMD and that HBV infection may accelerate the progression of AMD.
A Cluster-Adjusted Rank-Based Test for a Clinical Trial Concerning Multiple Endpoints With Application to Dietary Intervention Assessment
Authors: Zhang Wei , Liu Aiyi , Tang Larry L. , Li Qizhai 
Published: January 2019

Abstract
Multiple endpoints are often naturally clustered based on their scientific interpretations. Tests that compare these clustered outcomes between independent groups may lose efficiency if the cluster structures are not properly accounted for. For the two-sample generalized Behrens-Fisher hypothesis concerning multiple endpoints we propose a cluster-adjusted multivariate test procedure for the comparison and demonstrate its gain in efficiency over test procedures that ignore the clusters. Data from a dietary intervention trial are used to illustrate the methods.