bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the dynamic influences and interaction effects of signals on backers’ investment in the crowdfunding market
Authors: Song Yang , Wu Hong , Ma Jingdong , Lu Naiji 
Published: October 2019

Purpose
As a standard source of capital for entrepreneurs, crowdfunding has recently gained wide attention in business and academia. With scientific endorsement, some research is conducted to explore the antecedents of online crowdfunding success. The factors that can influence the backers’ investment which is the key to success are information from prior backers’ and creators’ behaviors. Based on the signaling theory, the purpose of this paper is to systematically investigate the dynamic influences and interaction effects of signals with different forms (action-based or opinion-based signals) and sources (creator-sourced or backer-sourced signals) on backers’ investment behaviors over a project-funding cycle.

Design/methodology/approach
A panel data set of 3,010 projects with 640,625 transaction records from April 28, 2013 to September 31, 2017 is collected from a famous online crowdfunding platform – Zhongchou.cn in China and the negative binomial panel data model with fixed effect is used to obtain our empirical results.

Findings
The findings demonstrate that the work of different signals is significantly effective at the early stage of a project and decreases with time. Furthermore, our results show that there are both synergistic effect and substitution effect among different signals. Specifically, the direction of interaction effect depends on the forms of signals and the backers’ sensitivity toward that signal, and the interaction effects are also dynamic.

Originality/value
This paper has shed light on the roles of different signal types and their interactions in influencing funding behavior over a project-funding cycle, enriched the literature on crowdfunding and provided both theoretical and practical implications.
Learn to build an error management culture
Authors: van Steenbergen Elianne , van Dijk Danny , Christensen Céline , Coffeng Tessa , Ellemers Naomi 
Published: October 2019

PurposeEmphasizing that errors are unacceptable and will be sanctioned does not prevent that errors are made – but can cause workers to cover up mistakes. Making an effort to identify things that go wrong to learn from them and prevent errors in the future offers a more fruitful approach. By sharing an applicable LEARN framework, this paper aims to inspire and give direction to financial corporations in building an error management culture within their organizations.Design/methodology/approachThe behavior and culture team of the Dutch Authority for the Financial Markets (AFM) collaborated closely with social and organizational psychologists from Utrecht University to study error management. The results of a literature study were combined with the findings obtained from a survey (N = 436) and in-depth interviews (N = 15) among employees of 13 Dutch financial corporations that are active within the infrastructure of the capital markets.FindingsTone at the top and direct managers’ behavior were positively related to error management culture, which in turn related to more learning. Combining these findings with relevant psychological literature resulted in the LEARN framework, which can guide organizations in developing actions and interventions to build an effective error management culture:Let the board take ownership,Engage employees,Align structure and culture,Refocus from person to system andNarrate the best examples.Originality/valueStimulating financial corporations to start building a healthier corporate culture by offering the LEARN framework – and recruiting insights from social and organizational psychology to do so – extends traditional supervisory approaches.
Does Egyptian universities’ disclosure on social responsibility enhance sustainable development?
Authors: Ismail Tariq H. 
Published: October 2019

Purpose
This study aims at investigating the extent to which Egyptian universities disclose information on social responsibility to different stakeholders, which leads to the enhancement of sustainable development.

Design/methodology/approach
An index of social responsibility that fits the Egyptian universities is established, comprising four dimensions: organizational governance, energy and environment resource sustainability, human resource development and community participation and community development. This index has been used to score the disclosure level of social responsibility of Egyptian universities. This study uses information available on websites of Egyptian universities as of the end of December 2018. Frequencies provide the basis for discussion.

Findings
The results reveal that the level of disclosure of universities on social responsibility is low, but, in favor of private universities vs public universities. At the university level, only a few numbers of public universities disclosed high volume of information on social responsibility, such as Cairo University, Ain Shams University, Alexandria University and Assiut University. Furthermore, the results manifest that public universities disclose higher level of information related to organizational governance, energy and environment resource sustainability and community participation and community development, whereas, private universities disclose higher level of information related to human resource development.

Research limitations/implications
The results are constrained with the social responsibility dimensions and attributes used to establish a disclosure index that fits Egyptian universities, as well as the information disclosed on universities websites.

Originality/value
This study provides insights to Egyptian higher education regulators and the rectors of Egyptian universities that may help in planning and monitoring social responsibility activities in a way that could lead to sustainable development.
The impact of sustainable board capital on sustainability reporting
Authors: Ngu Sie Bing , Amran Azlan 
Published: October 2019

Purpose
This aim of this paper is to prove that the diversity of board capital is a significant driver of corporate governance. Board capital has increasingly been identified as a key part of governance mechanism that assists businesses to improve their sustainability reporting practices and sustainability performance. In addition, board capital has been recognized as being key to the development of good corporate governance in the private and public sectors.

Design/methodology/approach
The paper discusses whether the diversity of board capital is a significant driver of corporate governance.

Findings
This paper suggests that the best mixture of board capital for an individual company should be varied between industries and business models. Effective corporate governance assists in the attainment of high-level sustainability and financial performance, which, in turn, bolsters corporate reputation.

Practical implications
This paper presents new strategic insights into diversity of board capital that is pivotal to global leading companies in preparing their sustainability reports.

Originality/value
This paper justifies the need of diversity in board capital because it is one of the means to build strong corporate governance based on the stakeholders’ expectations and interests, and to create greater public trust and the prospects of the respective business.
A hybrid framework for ranking the knowledge management solutions adoption in supply chains
Authors: Golghamat Raad Nima , Akbarpour Shirazi Mohsen 
Published: October 2019

Purpose
This paper aims to select and rank the solutions of knowledge management and apply them to the supply chain for boosting its performance. Therefore, organizations can focus on the high-priority solutions and assign the resources to the strategies related to these solutions.

Design/methodology/approach
A decision making trial and evaluation laboratory-based analytic network process method is first used to rank the barriers of implementing the knowledge solutions and preference ranking organization method for enrichment evaluations technique is then used to rank the knowledge-based solutions which improve the overall performance of the supply chain. Then, a mathematical model is proposed to select the best solutions where the effectiveness and fairness are maximized while the cost and risk are minimized. The proposed model is implemented over a dairy supply chain in Iran. The solutions are obtained using the literature and the experts’ panel of the supply chain.

Findings
Lack of trust and commitment of supply chain members, besides different interests, values and cultures of the supply chain members, is the most challenging barrier to knowledge management solution. Strengthening the cooperation culture in the chain, setting up a transparent workflow or open-door policy, setting up enough incentives and reward and punishment and setting up positive leadership toward knowledge management are the most important strategies for removing the existing barriers or decreasing their impact on the supply chain.

Originality/value
Solutions with the highest priority are not necessarily the best solutions for implementation; the requirements of organizations must also be considered. Mathematical model in this study helped to select solutions based on their cost and risk, as well as their priority level.
Development of a double‐antibody sandwich ELISA for sensitive detection of Yersinia pestis
Authors: Choi Sang‐Yoon , Rhie Gi‐eun , Jeon Jun Ho 
Published: October 2019

AbstractWe developed a biotin–streptavidin‐based sandwich ELISA for the sensitive and specific detection of Yersinia pestis. In this assay, the F1 capsular protein and Y. pestis were captured by anti‐F1 mouse monoclonal antibody followed by detection with biotinylated‐anti‐F1 rabbit polyclonal antibody and HRP‐conjugated streptavidin. The developed F1 ELISA could detect not only the F1 protein up to 29 and 17 pg/ml but also Y. pestis up to 177.8 and 129.2 CFU/ml in PBS buffer and human serum, respectively. In addition, the F1 ELISA did not show any cross‐reactivity with various proteins and bacterial strains.
An optimal Savitzky–Golay derivative filter with geophysical applications: an example of self‐potential data
Authors: Roy Indrajit G. 
Published: October 2019

ABSTRACTWe propose a strategy in designing an optimal set of filter parameters, such as the order of interpolating polynomial and the filter length for a Savitzky–Golay derivative filter. The proposed strategy is based on the ‘principle of parsimony’ while satisfying the optimality conditions. The optimality conditions are based on the Durbin–Watson lag‐1 test statistic and the Derringer–Suich desirability function. While the former checks for an appropriate data fitting, the latter, on the other hand, ensures minimal shape distortion of the reconstructed response. The proposed strategy of designing filter parameters is developed and validated through numerical experiments using Gaussian pulse as a test function which is contaminated with additive white Gaussian noise. In the numerical tests, the polynomial orders used were 3, 5 and 7, but the filter length for each polynomial was varying until the optimality conditions were satisfied. The Savitzky–Golay derivative filtering is used in obtaining the robust reconstruction of noisy geophysical anomaly and the robust estimation of its first‐ and second‐order derivatives. We validated the proposed technique on the published self‐potential anomaly data using a data‐based interpretation technique where the reconstructed anomaly and its first‐ and second‐order derivatives were used in estimating model parameters. The data‐based interpretation using the proposed technique of Savitzky–Golay derivative filtering provides a close agreement with the published results.
Intergenerational Differences in Income and Wealth: Evidence from Britain
Authors: Cribb Jonathan 
Published: October 2019

AbstractHow do average levels of income and wealth differ in Britain for those born between the 1930s and 1980s? Those in the 1980s cohort are the first post‐war generation not to have higher median incomes in their early 30s than those born a decade earlier, though they have much higher incomes than those born in the 1960s and earlier. Median wealth for those in the 1980s cohort is 20 per cent lower in their early 30s than it was for those born in the 1970s. This is driven by lower property wealth and homeownership: 40 per cent at age 30 for the 1980s cohort, compared with 55 per cent for the 1970s cohort.
Prevalence of undifferentiated inflammatory arthropathy in patients with Hashimoto's thyroiditis in an endocrinology clinic
Authors: Valderrama‐Hinds Luis M. , García‐Carrión Eliangel , Hernández Evelyn , Agostini María I. , Reyes‐Morales Omar R. , Fung Liliana , Al Snih Soham , Rodríguez Martin A. 
Published: October 2019

AbstractAimRheumatic manifestations are common in patients with Hashimoto's thyroiditis (HT). Since previous reports on the prevalence of arthritis in this disease may have a rheumatology referral bias, we sought to establish the prevalence of undifferentiated inflammatory arthropathy (UIA) in unselected HT patients as seen in an endocrinology clinic.MethodsCross‐sectional study of 92 consecutive HT patients and no definite rheumatic disease from the Endocrinology Division, Hospital Universitario de Caracas diagnosed by the presence of anti‐thyroid peroxidase antibodies (n = 68) or typical ultrasonographic findings (n = 24). Undifferentiated inflammatory arthropathy was defined as combination of morning stiffness and joint pain with ≥2 characteristics of inflammatory joint pain. The study was revised and approved by the Ethics Committee of our hospital and all patients signed an informed consent form.ResultsTwenty‐three patients (25%; 95% CI 16‐34) met the criteria for UIA. Joints most commonly affected were the knees, hands and ankles and the most common pattern was oligoarticular (82.6%). In the multivariate analysis, variables associated to the presence of UIA were the presence of myalgia (odds ratio [OR] = 19.41; 95% CI = 2.38‐158.38) and Raynaud's phenomenon (OR = 4.32; 95% CI = 1.01‐18.60). No association was found with demographics, duration of disease, comorbidities or thyroid function status.ConclusionsAlmost 1 in 4 patients with HT had no definite rheumatic disease present with UIA. An early identification of concurrent arthritis in HT patients is necessary for thorough differential diagnosis and prompt treatment initiation to halt potential joint damage and disability.
Declining hospitalisation and surgical intervention rates in patients with Crohn's disease: a population‐based cohort
Authors: Rahman Adam , Jairath Vipul , Feagan Brian G. , Khanna Reena , Shariff Salimah Z. , Allen Britney N. , Jenkyn Krista Bray , Vinden Christopher , Jeyarajah Jenny , Mosli Mahmoud , Benchimol Eric 
Published: October 2019

SummaryBackgroundLifetime risk of surgery in patients with Crohn's disease remains high.AimTo assess population‐level markers of Crohn's disease (CD) in the era of biological therapy.MethodsPopulation‐based cohort study using administrative data from Ontario, Canada including 45 235 prevalent patients in the Ontario Crohn's and Colitis Cohort (OCCC) from 1 April 2003 to 31 March 2014.ResultsCD‐related hospitalisations declined 32.4% from 2003 to 2014 from 154/1000 (95% confidence interval (CI) [150, 159]) patients to 104/1000 (95% CI [101, 107]) (P < .001). There was a 39.6% decline in in‐patient surgeries from 53/1000 (95% CI [50, 55]) to 32/1000 (95% CI [30, 34]) from 2003 to 2014 (P < .001). In‐patient surgeries were mostly bowel resections. Out‐patient surgeries increased from 8/1000 (95% CI [7, 9]) patients to 12/1000 (95% CI [10, 13]) (P < .001). Out‐patient surgeries were largely related to fistulas and perianal disease and for stricture dilations/stricturoplasty. CD‐related emergency department (ED) visits declined 28.4% from 141/1000 (95% CI [137, 146]) cases to 101/1000 (95% CI [99, 104]) from 2003 to 2014 (P < .001). Over the same time, patients receiving government drug benefits received infliximab or adalimumab at a combined rate of 2.2% in 2003 which increased to 18.8% of eligible patients by 2014.ConclusionsRates of hospitalisations, ED visits and in‐patient surgeries markedly declined in Ontario over the study period, while rates of biologic medication use increased markedly for those receiving public drug benefits.
Natural history of autoimmune atrophic gastritis: a prospective, single centre, long‐term experience
Authors: Miceli Emanuela , Vanoli Alessandro , Lenti Marco Vincenzo , Klersy Catherine , Di Stefano Michele , Luinetti Ombretta , Caccia Dominioni Costanza , Pisati Martina , Staiani Martina , Gentile Antonella , Capuano Francesca , Arpa Giovanni , Paulli Marco , Corazza Gino Roberto , Di Sabatino Antonio 
Published: October 2019

SummaryBackgroundAutoimmune atrophic gastritis (AAG) is an immune‐mediated disorder characterised by destruction of gastric oxyntic mucosaAimTo explore gastric histopathological evolution in a cohort of AAG patients over a prolonged follow‐upMethodsSingle centre prospective study enrolling consecutive patients with histologically confirmed AAG between 2000 and 2018. All AAG patients undergoing endoscopic follow‐up every 1‐3 years were classified as having stages 1, 2 or 3 according to atrophy severity (mild, moderate and severe). AAG patients with either glandular or neuroendocrine dysplasia/neoplasia were classified as having stage 4. Disease stage progression, and changes in serum anti‐parietal cell antibody (PCA), chromogranin A and gastrin‐17 were assessed.ResultsIn total, 282 AAG patients (mean age 60.3 years; F:M ratio 2.4:1; median follow‐up 3 years, interquartile range 1‐7) were enrolled. All patients with stages 1 or 2 progressed to stage 2 or 3 over time with a steady trend (P = .243) and regression from a severe to a milder stage was never noticed. Disease progression of patients with stages 1 or 2 occurred within the first 3 years. PCA positivity rate did not change over time. Stage 3 patients had higher gastrin‐17 levels compared to patients with stages 1 and 2 (median 606 vs 295 pg/mL; P < .001). In stage 3, the hazard ratio for the risk of developing stage 4 was 6.6 (95% CI 1.5‐29; P = .001).ConclusionsAAG is a steadily progressive disease, in which stages 1 and 2 always progress to stage 3. The risk of developing a complicated disease stage is greater in patients with more severe gastric lesions.
Spanish Guidelines for the use of targeted deep sequencing in myelodysplastic syndromes and chronic myelomonocytic leukaemia
Authors: Palomo Laura , Ibáñez Mariam , Abáigar María , Vázquez Iria , Álvarez Sara , Cabezón Marta , Tazón‐Vega Bárbara , Rapado Inmaculada , Fuster‐Tormo Francisco , Cervera José , Benito Rocío , Larrayoz María J. , Cigudosa Juan C. , Zamora Lurdes , Valcárcel David , Cedena María T. , Acha Pamela , Hernández‐Sánchez Jesús M. , Fernández‐Mercado Marta , Sanz Guillermo , Hernández‐Rivas Jesús M. , Calasanz María J. , Solé Francesc , Such Esperanza ,   On behalf of the Spanish Group of MDS (GESMD)
Published: October 2019

SummaryThe landscape of medical sequencing has rapidly changed with the evolution of next generation sequencing (NGS). These technologies have contributed to the molecular characterization of the myelodysplastic syndromes (MDS) and chronic myelomonocytic leukaemia (CMML), through the identification of recurrent gene mutations, which are present in >80% of patients. These mutations contribute to a better classification and risk stratification of the patients. Currently, clinical laboratories include NGS genomic analyses in their routine clinical practice, in an effort to personalize the diagnosis, prognosis and treatment of MDS and CMML. NGS technologies have reduced the cost of large‐scale sequencing, but there are additional challenges involving the clinical validation of these technologies, as continuous advances are constantly being made. In this context, it is of major importance to standardize the generation, analysis, clinical interpretation and reporting of NGS data. To that end, the Spanish MDS Group (GESMD) has expanded the present set of guidelines, aiming to establish common quality standards for the adequate implementation of NGS and clinical interpretation of the results, hoping that this effort will ultimately contribute to the benefit of patients with myeloid malignancies.
Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT/β‐catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide
Authors: Huang Peixian , Zhou Qiuping , Lin Qiongyu , Lin Lanfen , Wang Huifang , Chen Xuan , Jiang Shuqi , Fu Hui , Deng Yiyu 
Published: October 2019

AbstractNeuroinflammation is thought to play a pivotal role in the pathogenesis of periventricular white matter (PWM) damage (PWMD) induced by neonatal sepsis. Because the complement cascade is implicated in inflammatory response, this study was carried out to determine whether C3a is involved in PWMD, and, if so, whether it would induce axonal hypomyelination. Furthermore, we explored if C3a would act through its C3a receptor (C3aR) and thence inhibit maturation of oligodendrocyte precursor cells (OPCs) via the WNT/β‐catenin signal pathway. Sprague Dawley (SD) rats aged 1 day were intraperitoneally injected with lipopolysaccharide (LPS) (1 mg/kg). C3a was upregulated in activated microglia and astrocytes in the PWM up to 7 days after LPS injection. Concomitantly, enhanced C3aR expression was observed in NG2+ oligodendrocytes (OLs). Myelin proteins including CNPase, PLP, MBP and MAG were significantly reduced in the PWM of 28‐day septic rats. The number of PLP+ and MBP+ cells was markedly decreased. By electron microscopy, myelin sheath thickness was thinner and the average g‐ratios were higher. This was coupled with an increase in number of NG2+ cells and decreased number of CC1+ cells. Olig1, Olig2 and SOX10 protein expression was significantly reduced in the PWM after LPS injection. Very strikingly, C3aRa administration for the first 7 days could reverse the above‐mentioned pathological alterations in the PWM of septic rats. When incubated with C3a, expression of MBP, CNPase, PLP, MAG, Olig1, Olig2, SOX10 and CC1 in primary cultured OPCs was significantly downregulated as opposed to increased NG2. Moreover, WNT/β‐catenin signaling pathway was found to be implicated in inhibition of OPCs maturation and differentiation induced by C3a in vitro. As a corollary, it is speculated that C3a in the PWM of septic rats is closely associated with the disorder of OPCs differentiation and maturation through WNT/β‐catenin signaling pathway, which would contribute ultimately to axonal hypomyelination.