bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlinear relations between post‐traumatic stress symptoms and electrocortical reactivity during emotional face processing in combat‐exposed veterans
Authors: Macatee Richard J. , Burkhouse Katie L. , Afshar Kaveh , Schroth Christopher , Aase Darren M. , Greenstein Justin E. , Proescher Eric , Phan K. Luan 
Published: June 2019

AbstractCombat‐related post‐traumatic stress symptoms (PTSS) are prevalent among recently deployed veterans, making identification of biomarkers of PTSS in this population a public health priority. Given the link between threat processing neurobiology and PTSS, the threat‐related late positive potential (LPP), an ERP reflective of attentional processing sensitive to emotion and its regulation, may have utility as a cost‐effective biomarker. Existing PTSS/threat‐related LPP findings are mixed, possibly due to variability in PTSS across samples, but this has never been explicitly tested. To address this gap, LPP amplitudes to angry, fearful, and happy emotional face stimuli were recorded among 81 combat‐exposed veterans at a VA hospital. A quadratic relationship between self‐reported PTSS and LPP amplitude modulation by angry faces emerged such that greater PTSS was related to a decreased LPP response to angry faces among veterans with subthreshold PTSD and an enhanced LPP response to angry faces among veterans with probable PTSD. These results suggest that prior mixed findings may be due to variability in PTSS severity. In addition, exploratory moderation analysis revealed that PTSS was positively associated with late LPP modulation for veterans reporting low cognitive reappraisal use and negatively associated with late LPP modulation for veterans reporting high cognitive reappraisal use. All results were specific to the 1,000–3,000 ms LPP time window. Thus, the functional nature of LPP modulation by direct threat cues may depend upon PTSS severity and/or related variables (e.g., cognitive reappraisal utilization).
Hemolytic anemia, spherocytosis, and thrombocytopenia associated with honey bee envenomation in a dog
Authors: Nair Rajeev , Riddle Emily A. , Thrall Mary Anna 
Published: June 2019

AbstractThis case report describes a massive honey bee envenomation in a 14‐month‐old male Belgian Malinois dog from St. Kitts, West Indies. Acute and delayed onsets of hemolytic anemia, echinocytosis, spherocytosis, thrombocytopenia, hemoglobinemia, and hemoglobinuria developed following envenomation. The dog recovered after treatment with glucocorticoids and supportive therapy. Spherocytosis, hemolysis, and thrombocytopenia in patients with massive bee envenomation are likely due to the direct toxic effects of the primary components of bee venom, melittin and phospholipase A2(PLA2). Mellitin causes hemolysis by forming large pores in erythrocytes resulting in leakage of hemoglobin and also causes spectrin stiffening and resultant echinocyte and spherocyte formation. Melittin also stimulates PLA2, a hydrolase that causes echinocytosis and spherocytosis, in vivo and in vitro, and mitochondrial breakdown in platelets. However, delayed manifestations could be attributed to immune‐mediated mechanisms from the generation of antibodies against damaged erythrocytes and platelet membrane proteins.
Methadone, Pierre Robin sequence and other congenital anomalies: case–control study
Authors: Cleary Brian , Loane Maria , Addor Marie-Claude , Barisic Ingeborg , de Walle Hermien E K , Matias Dias Carlos , Gatt Miriam , Klungsoyr Kari , McDonnell Bob , Neville Amanda , Pierini Anna , Rissmann Anke , Tucker David F , Zurriaga Oscar , Dolk Helen 
Published: June 2019

ObjectiveMethadone is a vital treatment for women with opioid use disorder in pregnancy. Previous reports suggested an association between methadone exposure and Pierre Robin sequence (PRS), a rare craniofacial anomaly. We assessed the association between gestational methadone exposure and PRS.Design/settingThis case-malformed control study used European Surveillance of Congenital Anomalies population-based registries in Ireland, the Netherlands, Italy, Switzerland, Croatia, Malta, Portugal, Germany, Wales, Norway and Spain, 1995–2011.PatientsCases included PRS based on International Classification of Disease (ICD), Ninth Edition-British Paediatric Association (BPA) code 75 603 or ICD, Tenth Edition-BPA code Q8708. Malformed controls were all non-PRS anomalies, excluding genetic conditions, among live births, fetal deaths from 20 weeks’ gestation and terminations of pregnancy for fetal anomalies. An exploratory analysis assessed the association between methadone exposure and other congenital anomalies (CAs) excluding PRS. Methadone exposure was ascertained from medical records and maternal interview.ResultsAmong 87 979 CA registrations, there were 127 methadone-exposed pregnancies and 336 PRS cases. There was an association between methadone exposure and PRS (OR adjusted for registry 12.3, 95% CI 5.7 to 26.8). In absolute terms, this association reflects a risk increase from approximately 1–12 cases per 10 000 births. A raised OR was found for cleft palate (adjusted OR 5.0, 95% CI 2.7 to 9.2).ConclusionsThese findings suggest that gestational methadone exposure is associated with PRS. The association may be explained by unmeasured confounding factors. The small increased risk of PRS in itself does not alter the risk–benefit balance for gestational methadone use. The association with cleft palate, a more common CA, should be assessed with independent data.
Antihyperalgesia effect of AMP-activated protein kinase (AMPK) activators in a mouse model of postoperative pain
Authors: Das Vaskar , Kroin Jeffrey S , Moric Mario , McCarthy Robert J , Buvanendran Asokumar 
Published: June 2019

Background and objectivesAMP-activated protein kinase (AMPK) activator drugs decrease hypersensitivity in mice with pain. This study examines if postsurgery treatment with the prototype AMPK activator metformin and a new mechanism-specific AMPK activator, O304, after plantar hindpaw incision in mice, would reduce mechanical hypersensitivity and produce changes in the AMPK pathway in the dorsal root ganglion (DRG).MethodsTo create postoperative pain, an incision was made in the left plantar hindpaw. Animals were randomized into four oral gavage drug treatment groups (n=8/group): (1) vehicle, (2) metformin 200 mg/kg, (3) O304 200 mg/kg and (4) O304 200 mg/kg plus metformin 200 mg/kg. Drug gavages were performed 4 hours postsurgery and were repeated for 3 days. Mechanical hypersensitivity was measured with von Frey filaments. Changes in phosphorylated AMP-activated protein kinase alpha subunit, phosphorylated mechanistic target of rapamycin and phosphorylated eukaryotic initiation factor 2 alpha in DRG neurons were examined by immunohistochemistry.ResultsO304 or metformin increased von Frey thresholds (reduced mechanical hypersensitivity) in plantar incision mice versus vehicle-treated incision mice between days 1 and 4 (difference of mean area under the curve, O304: 2.24 g*day; 95% CI of the difference 0.28 to 4.21, p=0.011; metformin: 2.56 g*day; 95% CI of the difference 1.71 to 3.41, p<0.001). The drug combination further elevated von Frey thresholds. In the vehicle-treated group, the AMP-activated protein kinase alpha subunit was downregulated and mechanistic target of rapamycin and eukaryotic initiation factor 2 alpha were upregulated in DRG neurons; these deficits were reversed by the AMPK activator treatments.ConclusionsEarly treatment with the mechanism-specific AMPK activator O304 or the prototype AMPK activator metformin reduces mechanical hypersensitivity in a postoperative pain model in mice. These drugs also normalize the AMPK pathway in the DRG.
Cost‐Effectiveness of Left Atrial Appendage Closure for Stroke Reduction in Atrial Fibrillation: Analysis of Pooled, 5‐Year, Long‐Term Data
Authors: Reddy Vivek Y. , Akehurst Ronald L. , Gavaghan Meghan B. , Amorosi Stacey L. , Holmes David R. 
Published: June 2019

Background
Recent publications reached conflicting conclusions about the cost‐effectiveness of left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, Marlborough, MA) for stroke risk reduction in nonvalvular atrial fibrillation (AF). This analysis sought to assess the cost‐effectiveness of LAAC relative to both warfarin and nonwarfarin oral anticoagulants (NOACs) using pooled, long‐term data from the randomized PROTECT AF (Watchman Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillation) and PREVAIL (Prospective Randomized Evaluation of the Watchman LAA Closure Device in Patients With Atrial Fibrillation Versus Long‐Term Warfarin) trials.

Methods and Results
A Markov model was constructed from a US payer perspective with a lifetime (20‐year) horizon. LAAC clinical event rates and stroke outcomes were from pooled PROTECT AF and PREVAIL trial 5‐year data. Warfarin and NOAC inputs were derived from published meta‐analyses. The model was populated with a cohort of 10 000 patients, aged 70 years, at moderate stroke and bleeding risk. Sensitivity analyses were performed. LAAC was cost‐effective relative to warfarin by year 7 ($48 674/quality‐adjusted life‐year) and dominant (more effective and less costly) by year 10. LAAC became cost‐effective and dominant compared with NOACs by year 5. Over a lifetime, LAAC provided 0.60 more quality‐adjusted life‐years than warfarin and 0.29 more than NOACs. In sensitivity analyses, LAAC was cost‐effective relative to warfarin and NOACs in 98% and 95% of simulations, respectively.

Conclusions
Using pooled, 5‐year PROTECT AF and PREVAIL trial data, LAAC proved to be not only cost‐effective, but cost saving relative to warfarin and NOACs. LAAC with the Watchman device is an economically viable stroke risk reduction strategy for patients with AF seeking an alternative to lifelong anticoagulation.
Impact of Sex on Ventricular‐Vascular Stiffness and Long‐Term Outcomes in Heart Failure With Preserved Ejection Fraction: TOPCAT Trial Substudy
Authors: Beale Anna L. , Nanayakkara Shane , Kaye David M. 
Published: June 2019

Background
Women have higher vascular stiffness with aging. The aim of this study was to characterize sex differences in vascular and ventricular structure and function, and to investigate the impact on the primary outcome in the TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial).

Methods and Results

Data from the Americas cohort of the
TOPCAT
trial were analyzed. Patients with echocardiography (n=654) were compared according to sex, and achievement of the primary end point (a composite of death from cardiovascular causes and heart failure hospitalization) assessed. Echocardiography revealed higher arterial, systolic, and diastolic ventricular elastance and worse ventricular‐vascular coupling in women. Women had better overall survival and heart failure hospitalization outcomes (hazard ratio 0.74, 95%
CI
0.57–0.98,
P
=0.034), however, determinants of achievement of the primary outcome differed between the sexes. Pulse pressure was a key determinant of outcome in women (hazard ratio 1.04, 95%
CI
1–1.09,
P
=0.034) whereas in men heart rate (hazard ratio 1.61, 95%
CI
1.02–2.52 per 10 mm Hg increase,
P
=0.04) and B‐type natriuretic peptide (hazard ratio 1.01, 95%
CI
1–1.02 per 10 ng/mL increase
P
=0.02) were associated with poorer outcome.

Conclusions
Outcomes in patients with heart failure with preserved ejection fraction appear to be differentially influenced by key physiological factors that vary according to sex. In women, ventricular‐vascular stiffening was the most significant determinant of outcome, whereas in men overall survival was influenced by heart rate and B‐type natriuretic peptide; this highlights key sex differences in the pathophysiology and outcomes of heart failure with preserved ejection fraction and warrants further exploration.

Clinical Trial Registration

URL:
https://clinicaltrials.gov
. Unique identifier: NCT00094302.
Who will benefit more from low-dose alteplase in acute ischemic stroke?
Authors: Wang Xia , Lee Keon-Joo , Moullaali Tom J , Kim Beom Joon , Li Qiang , Bae Hee-Joon , Carcel Cheryl , Delcourt Candice , Arima Hisatomi , Sato Shoichiro , Robinson Thompson G , Song Lili , Chen Guofang , Yang Jie , Chalmers John , Anderson Craig S , Lindley Richard , Woodward Mark ,   for the ENCHANTED Investigators
Published: June 2019

Objectives Controversy persists over the benefits of low-dose versus standard-dose intravenous alteplase for the treatment of acute ischemic stroke. We sought to determine individual patient factors that contribute to the risk–benefit balance of low-dose alteplase treatment. Methods Observational study using data from the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED), an international, randomized, open-label, blinded-endpoint trial that assessed low-dose (0.6 mg/kg) versus standard-dose (0.9 mg/kg) intravenous alteplase in acute ischemic stroke patients. Logistic regression models were used to estimate the benefit of good functional outcome (scores 0 or 1 on the modified Rankin scale at 90 days) and risk (symptomatic intracerebral hemorrhage), under both regimens for individual patients. The net advantage for low-dose, relative to standard-dose, alteplase was calculated by dividing excess benefit by excess risk according to a combination of patient characteristics. The algorithms were externally validated in a nationwide acute stroke registry database in South Korea. Results Patients with an estimated net advantage from low-dose alteplase, compared with without, were younger (mean age of 66 vs. 75 years), had lower systolic blood pressure (148 vs. 160 mm Hg), lower National Institute of Health Stroke Scale score (median of 8 vs. 16), and no atrial fibrillation (10.3% vs. 97.4%), diabetes mellitus (19.2% vs. 22.4%), or premorbid symptoms (defined by modified Rankin scale = 1) (16.3% vs. 37.8%). Conclusion Use of low-dose alteplase may be preferable in acute ischemic stroke patients with a combination of favorable characteristics, including younger age, lower systolic blood pressure, mild neurological impairment, and no atrial fibrillation, diabetes mellitus, or premorbid symptoms.
Endoscopic Removal of Migrated Intrauterine Device: Case Report and Review of Literature and Technique
Authors: Lei Yang , Iablakov Vadim , Karmali Riaz J. , Forbes Nauzer 
Published: June 2019

ABSTRACT
Intrauterine devices (IUDs) are commonly used contraceptive methods. Uterine perforation and device migration are rare but have been/are previously described as adverse events. Migration of the perforated IUD into the bowel is rare and generally requires surgical removal. We describe the endoscopic removal of an IUD embedded in the rectal wall in an otherwise healthy patient. Extraction of the IUD was uncomplicated, well tolerated, and followed by same-day hospital discharge. No prophylactic hemostasis or antimicrobial coverage was needed. We also present a comprehensive review of the reported endoscopic IUD removal. We recommend close investigation and follow-up when pregnancy or other potential signs of IUD migration occur. Endoscopic removal appears to be a safe and cost-effective technique for the extraction of IUDs that migrate into the bowel lumen.
Celiac Artery Portal Vein Fistula After Transjugular Intrahepatic Portosystemic Shunt Presenting as Heart Failure
Authors: Kathi Pradeep Reddy , Thammineni Nikhila , Dhillon Kunwardeep , Kundumadam Shankerdas , Goyal Sachin 
Published: June 2019

ABSTRACT
Transjugular intrahepatic portosystemic shunt (TIPS) is an important therapeutic tool available to decrease portal vein pressure in patients with cirrhosis and portal hypertension. TIPS is associated with various complications, and fistula formation is an important one to be noted. We present an unusual and interesting case of a patient who developed right-sided heart failure 5 months after TIPS placement. Diagnostic workup revealed an uncommon fistula between the celiac artery trunk and portal vein that was successfully treated with angiography-guided embolization, resulting in clinical improvement.
On mixed Lp
John ellipsoids
Authors: Hu Jiaqi , Xiong Ge , Zou Du 
Published: June 2019

Abstract
A new family of ellipsoids associated with a pair of convex bodies in ℝ
n
is introduced, which extends the classical John ellipsoids and the evolved Lp
John ellipsoids in a distinctive way. Analogues of John’s inclusion and Ball’s volume-ratio inequality are established for these new ellipsoids.
Image Milnor number and 𝒜
e
-codimension for maps between weighted homogeneous irreducible curves
Authors: Ament D. A. H. , Nuño-Ballesteros J. J. , Tomazella J. N. 
Published: June 2019

Abstract
Let (X, 0) ⊂ (ℂ
n
, 0) be an irreducible weighted homogeneous singularity curve and let f : (X, 0) → (ℂ2, 0) be a finite map germ, one-to-one and weighted homogeneous with the same weights of (X, 0). We show that 𝒜
e
-codim(X, f) = μI
(f), where the 𝒜
e
-codimension 𝒜
e
-codim(X, f) is the minimum number of parameters in a versal deformation and μI
(f) is the image Milnor number, i.e. the number of vanishing cycles in the image of a stabilization of f.
Comparison of geotourism assessment models: and experiment in Bakony–Balaton UNSECO Global Geopark, Hungary
Authors: Pál Márton , Albert Gáspár 
Published: June 2019

Abstract
Geological and scenic values of locations are the non-living curiosities that can be preserved and popularized a lot easier using the institutional background of geotourism, such as geoparks. UNESCO Global Geoparks Network is responsible for protecting and fostering natural, scenic and cultural values and especially geosites that are the exciting visible physical elements. Our goal was to quantify the geotourism potential around Csopak, a scenic village in the Balaton Uplands giving home for the headquarter of the Bakony-Balaton UNESCO Global Geopark. After designating 216 potential geosites using topographic and geological maps, we applied two assessment models: the Geosite Assessment Model (GAM) and the Modified Geosite Assessment Model (M-GAM). GAM has been applied with good results in Hungary on different areas, but M-GAM has not been used before. As M-GAM involves tourists into the process counting with their opinion, it may give a more realistic view of the geosites. The two methods produced different but comparable final values of geotourism potential counted from the Main Value and Additional Value scores. We discovered that the proportion of the difference of these values carries major information. The ratio of ΔAV/ΔMV used as linear functions and depicted on diagrams can derive which values are more important for the visitors. From this result we can draw conclusions about the future development trends: scientific or infrastructural values should be more effectively fostered. Using our results, geosites can be handled and developed as visitors expect it.
Notes on the impact of cycling infrastructure on tourist destination management
Authors: Šebešová Adriana , Kršák Branislav 
Published: June 2019

Abstract
There has been a large support given to building of cycling routes in Slovakia for last few years at all levels and many aspects. Not just legislative, strategic and technical point of view but also financial support is necessary to take in account. According to this big effort is necessary to be more focused on a question of evaluation of impacts on local communities. This article deals with analysis of cycling infrastructure impact on destination performance.
An Exploratory Cross-Country Analysis of Female Entrepreneurial Activity: The Roles of Gendered Institutions
Authors: Wu Juan , Li Yaokuang 
Published: June 2019

AbstractThe use of a gender-neutral approach to explore the contextual determinants of female entrepreneurship may preclude us from unraveling the complex institutions that tend to treat men and women asymmetrically, namely gendered institutions. This paper uses institutional theory to highlight different institutional patterns from a gendered perspective. In particular, drawing upon Scott’s well-known formulation of three institutional categories, we examine how three pillars of gendered institutions—regulative, normative and cognitive gendered institutions—shape both the absolute and the relative levels of female entrepreneurial activity, that is, female total early-stage entrepreneurial activity (TEA) rate and female/male TEA ratio. Using cross-sectional data for 63 countries in 2013, we employ exploratory factor analysis, confirmatory factor analysis and multiple linear regression analysis and find that all three dimensions of gendered institutions have significant influences on the relative levels of female entrepreneurial activity, while only regulative and cognitive gendered institutions are significantly related to the absolute level of female entrepreneurship. Specifically, regulative gendered institutions have negative impacts, while cognitive gendered institutions have positive impacts. In addition, among the three distinct dimensions of gendered institutions, cognitive gendered institutions have the most important effect on both levels of female entrepreneurship. Implications for research and policy are discussed.
Implicit Causality in younger and older adults
Authors: Bittner Dagmar 
Published: June 2019

Abstract
The study asked whether there are age-related differences in the Implicit Causality values (IC-values) of transitive verbs in younger and older adults. The results are expected to support either linguistic accounts or world-knowledge accounts of the origin of Implicit Causality. Using the traditional sentence-completion task (John VERBs Mary, because …) 124 verbs were investigated in a group of students around age 23 and in a group of older people around age 81. Compared to the students, the older people produced higher proportions of Object-reference with verbs showing Subject-reference in general and higher Subject-reference with verbs showing Object-reference in general. Verb-class analysis in terms of semantic role patterns showed that the IC-values of SE-verbs and ES-verbs were less different in the two groups than those of SE-AP-verbs, AP-verbs, and APpres-verbs. The differences in the two latter classes are significant. The relatively broad similarity in the IC-values of the two age groups supports linguistic accounts of the origin of IC-values. The observed differences, however, point to variation in the perspective on interpersonal events in younger and older adults. It is hypothesized that the latter observation reflects an impact of world knowledge on IC-values in that the social life situations of younger and older adults shape expectations regarding who is causing an interpersonal event somewhat differently in the two age groups.
Language and aging research: new insights and perspectives
Authors: Gerstenberg Annette , Lindholm Camilla 
Published: June 2019

Abstract
Our introduction to the special collection gives an overview of the research projects which were originally presented at the third CLARe network conference. We group the research under four cross-sectional topics that unite the different contributions: the data used in the research, the theoretical frameworks, the languages and varieties which are represented and the situational contexts which are examined. These projects represent the current state of research in this field and allows the reader to orient themselves within this diverse field but also leaves many questions open and provides impetus for future lines of research. The interaction and collaboration between diverse disciplines is the central aspect which unites all contributions to the special collection.
Crystal structure of dihydrazinium 1H-pyrazole-3,5-dicarboxylate, C5H12N6O4
Authors: Latinović Nedeljko , Novaković Sladjana B. , Bogdanović Goran A. , Kastratović Vlatko , Giester Gerald , Jaćimović Željko K. 
Published: June 2019

Abstract
C5H12N6O4, monoclinic, P21/n (no. 14), a = 4.3368(6) Å, b = 15.483(2) Å, c = 13.8852(19) Å, β = 97.714(3)°, V = 923.9(2) Å3, Z = 4, R
gt(F) = 0.0411, wR
ref(F
2) = 0.1109, T = 200(2) K.