bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol-responsive genes identified in human iPSC-derived neural cultures
Authors: Jensen Kevin P. , Lieberman Richard , Kranzler Henry R. , Gelernter Joel , Covault Jonathan 
Published: July 2018

AbstractAlcohol use contributes to numerous diseases and injuries. The nervous system is affected by alcohol in diverse ways, though the molecular mechanisms of these effects are not clearly understood. Using human-induced pluripotent stem cells (iPSCs), we developed a neural cell culture model to identify the mechanisms of alcohol’s effects. iPSCs were generated from fibroblasts and differentiated into forebrain neural cells cultures that were treated with 50 mM alcohol or sham conditions (same media lacking alcohol) for 7 days. We analyzed gene expression using total RNA sequencing (RNA-seq) for 34 samples derived from 11 subjects and for 10 samples from 5 subjects in an independent experiment that had intermittent exposure to the same dose of alcohol. We also analyzed genetic effects on gene expression and conducted a weighted correlation network analysis. We found that differentiated neural cell cultures have the capacity to recapitulate gene regulatory effects previously observed in specific primary neural tissues and identified 226 genes that were differentially expressed (FDR< 0.1) after alcohol treatment. The effects on expression included decreases inINSIG1andLDLR,two genes involved in cholesterol homeostasis. We also identified a module of 58 co-expressed genes that were uniformly decreased following alcohol exposure. The majority of these effects were supported in the independent alcohol exposure experiment. Enrichment analysis linked the alcohol responsive genes to cell cycle, notch signaling, and cholesterol biosynthesis pathways, which are disrupted in several neurological disorders. Our findings suggest that there is convergence between these disorders and the effects of alcohol exposure.
Architecture of parallel adaptation to freshwater in multiple populations of threespine stickleback
Authors: Terekhanova Nadezhda V. , Barmintseva Anna E. , Kondrashov Alexey S. , Bazykin Georgii A. , Mugue Nikolai S. 
Published: July 2018

AbstractThreespine sticklebacks adapted to freshwater environments all over the Northern Hemisphere. This adaptation involved parallel recruitment of freshwater alleles in clusters of closely linked sites, or divergence islands (DIs). However, it is unclear to what extent the DIs involved in adaptation and the alleles within them coincide between populations adapting to similar environments. Here, we examine 10 freshwater populations of similar ages from the White Sea basin, and study the repeatability of patterns of adaptation in them. Overall, the 65 detected DIs tend to reside in regions of low recombination, underlining the role of reduced recombination in their establishment. Moreover, the DIs are clustered in the genome to the extent that is not explainable by the recombination rate alone, consistent with the divergence hitchhiking model. 21 out of the 65 DIs are universal; i.e., the frequency of freshwater alleles in them is increased in all analyzed populations. Universal DIs tend to have longer core region shared between populations, and the divergence between the marine and the freshwater haplotypes in them is higher, implying that they are older, also consistently with divergence hitchhiking. Within most DIs, the same set of sites distinguished the marine and the freshwater haplotypes in all populations; however, in some of the DIs, the genetic architecture of the freshwater haplotype differed between populations, suggesting that they could have been established by soft selective sweeps.
Lesion Attributes Segmentation for Melanoma Detection with Deep Learning
Authors: Chen Eric Z. , Dong Xu , Wu Junyan , Jiang Hongda , Li Xiaoxiao , Rong Ruichen 
Published: July 2018

ABSTRACTMelanoma is the most deadly form of skin cancer world-wide. Many efforts have been made for early detection of melanoma. The International Skin Imaging Collaboration (ISIC) hosted the 2018 Challenges to improve the diagnosis of melanoma based on dermoscopic images. In this paper, we describe our solution for the task 2 of ISIC 2018 Challenges. We present a multi-task U-Net model to automatically detect lesion attributes of melanoma. Our multi-task U-Net deep learning model achieves a Jaccard index of 0.433 on official test data, which ranks the 5th place on the final leaderboard.
Monetary model of exchange rate determination under floating and non-floating regimes
Authors: Ibhagui Oyakhilome Wallace 
Published: July 2018

Purpose
The purpose of this paper is to empirically analyse how different exchange rate regimes affect the links between monetary fundamentals and exchange rates in Sub-Saharan Africa.

Design/methodology/approach
Using the Pedroni method for panel cointegration, mean group and pooled mean group and the panel vector autoregressive technique, this study empirically investigates whether monetary fundamentals impact exchange rates similarly in both regimes. Thus, the author acquires needed and credible empirical data.

Findings
The result suggests that the impact is dissimilar. In the floating regime, an increase in relative money supply and relative real output depreciates and appreciates the nominal exchange rate in the long run whereas in the non-floating regime, the evidence is mixed. Thus, exchange rates bear a theoretically consistent relationship with monetary fundamentals across SSA countries with floating regimes but fails under non-floating regimes. This provides evidence that regime choice is important if the relationship between monetary fundamentals and exchange rates in SSA are to be theoretically consistent.

Originality/value
This study empirically incorporates the dissimilarities in exchange rate regimes in a panel framework and study the links between exchange rates and monetary fundamentals. The focus on how exchange rate regimes might alter the equilibrium relationships between exchange rates and monetary fundamentals in SSA is a pioneering experiment.
Addressing free riders in collaborative group work
Authors: El Massah Suzanna Sobhy 
Published: July 2018

Purpose
Free-riding behaviour may threaten the success of teamwork, when one or more group members receive the benefits of other members’ achievements with little effort or cost of their own. The purpose of this paper is to investigate students’ collaborative behaviour to address the problem of free riders (FRs) in university settings.

Design/methodology/approach
The research is an 11-week field study of three senior finance classes and incorporates mobile learning employing Quip and Google Docs applications to facilitate group work. A comprehensive set of quantitative and qualitative methods analysing students’ perceptions, instructors’ reflections, peer reflections and mobile learning methods are used to answer questions pertaining to group work, the work experience, FRs and ways to minimise the last.

Findings
In this paper, the author shows that students at the university level have positive views of group work despite the presence of FRs. Students like to form their own groups; consequently, peer evaluation appears to be unreliable. The study points to free riding as a serious threat to academic productivity and calls for actions and strategies from institutions and instructors to eradicate this behaviour. Mobile applications enable instructors to track FRs and to some extent discourage their behaviour.

Originality/value
There are limited studies that focus on FRs in higher education and, to the researcher’s knowledge, no such investigation has been applied in the Middle East and North Africa. Likewise, there is little research available on incorporating mobile learning to assess group work in higher education. This study aims at exploring the existence and associated experiences of free riding, along with methods to curtail the problem. The findings of this study provide a good platform for inquiry into the FR phenomenon in higher education and its impact on student learning, as well as the possible roles of instructors and mobile applications. The findings of this study could be developed further through more research with a view to providing a broader perspective of the situation in Middle Eastern and North African cultures.
Academics’ experience of contradicting institutional logics of publishing
Authors: Aksom Herman 
Published: July 2018

PurposeThe purpose of this paper is to explore whether and how Ukrainian scholars recognize and react to a situation of an absence of two major institutional logics of academic writing and publishing, namely the logics of science advancement and personal career promotion and the dominance of the logic of coercive pressures to publish regardless of quality and resonance and with no material and reputational rewards. Two fundamental and essential logics that drive research activity at any university in western societies seem to be almost absent in Ukrainian context, where symbolic publishing for accountability only is taken-for-granted.Design/methodology/approachThe study adopts qualitative interpretative research methodology. The scholars from seven universities were interviewed, including 16 senior scholars and 15 PhD students.FindingsThe study shows the dominance of a single logic of accountability which is persisted due to coercive pressures exerted on scholars. Despite the absence of instrumental value behind publishing requirements in Ukrainian higher education system, most academics do not question this policy and largely take it for granted as the only possible system.Originality/valueResearch conducted in this study contributes to institutional logics and institutional complexity literature by highlighting a unique situation of institutional complexity when logic that offers neither economic nor social benefits dominates the field. It is shown how actors recognize, interpret and respond to this situation, identifying three types of responses that range from blind adherence to taken-for-granted institutional definitions to strategic balance between coercive pressures and desired logics.
School business managers in England: negotiating identity
Authors: Armstrong Paul Wilfred 
Published: July 2018

Purpose
The purpose of this paper is to explore the concept of group identity formation amongst school business managers in the English school system.

Design/methodology/approach
Data were generated via a research project that employed semi-structured interviews with school business managers as a means of exploring their experiences as a relatively nascent group, carving out their own territory within a school system traditionally led and managed by trained educationalists.

Findings
The findings provide insight into the enabling and inhibiting factors encountered by school business managers in establishing and negotiating a distinguishable group identity within the wider school workforce including their variable career trajectories and motives, the suitability of their qualifications and the diverse composition of their roles.

Originality/value
The paper throws light on the identity formation of a cohort of the school workforce in England who are not directly involved in educational leadership or classroom practice but nevertheless play a crucial role in the ecosystem of the school. While the research reported is situated within England, the issues raised can be applied to education systems in other contexts given the universal importance of financial and organizational management in schools.
Course leadership in small specialist UK higher education – a review
Authors: van Veggel Nieky , Howlett Philip 
Published: July 2018

Purpose
The purpose of this paper is to review the literature with regard to the course leader in small and specialist higher education in the UK.

Design/methodology/approach
First, the role of the course leader is explored, followed by an evaluation of the barriers to effective course management. This is then followed by a discussion of mitigating solutions to the barriers identified. Course leadership is then reviewed in the context of small and specialist higher education. Finally, areas for future research are suggested.

Findings
Course leadership in the UK is a role with wide ranging responsibilities, but is under-appreciated by the higher education sector. Various barriers have been identified, and some solutions proposed, in the literature, but problems remain.

Originality/value
Course leadership is an underappreciated area with little academic literature available, even though issues have been reported since the 1990s. This paper critically evaluates and summarises the issues, and shows that they are still current. It also proposes solutions and areas of further research so that issues can be resolved for betterment of the higher education sector.
How ethical leadership stimulates academics’ retention in universities
Authors: Ahmad Saima , Fazal-E-Hasan Syed Muhammad , Kaleem Ahmad 
Published: July 2018

PurposeThe purpose of this paper is to investigate the relationship between ethical leadership and academics’ retention in universities. It draws on the conservation of resources theory to deepen the understanding of a process underlying this relationship whereby academics are more likely to stay in universities through the practice of ethical leadership. Specifically, it advances academics’ job-related affective well-being as a potential mediating mechanism, fostered by ethical leadership, which lowers their intention to leave.Design/methodology/approachThis study is conducted through a cross-sectional survey of 303 academics in Australian universities. Univariate, bivariate and multivariate analysis procedures are deployed to analyse academics’ data. The research hypotheses are tested through a bootstrapped regression analysis of academics’ perceived ethical leadership, affective well-being and intention to leave.FindingsThe findings lend support to the hypothesised relations, indicating a significant role of ethical leadership on enhanced intentions of academics to stay in universities by directly conserving their job-related affective well-being.Research limitations/implicationsThis paper contributes to knowledge of the relationship between ethical leadership and academics’ retention by identifying job-related affective well-being as an underlying mechanism in the university sector.Practical implicationsThis paper has practical implications for higher educational institutes seeking to retain their academic staff. Its findings show that the practice of ethical leadership in universities matters, because it lowers academics’ intentions to leave by nurturing their well-being at work.Originality/valueThis is the first study to examine the impact of ethical leadership on academics’ well-being and intentions to leave in the context of universities in Australia. It is one of the first studies to explore the mediating role of affective well-being in the ethical leadership and leadership and intention to leave relationship.
Impact of investment in intangible assets on corporate performance in India
Authors: Bhatia Aparna , Aggarwal Khushboo 
Published: July 2018

Purpose
The purpose of this paper is to evaluate the impact of investment in Intangible Assets on the corporate performance of Indian companies for a period of twelve years from 2001 to 2012.

Design/methodology/approach
Intangible assets have been measured using the “Intangible Assets Monitor” method developed by Sveiby (1997).

Findings
The results of panel data regression model reveal that Intangible Assets affect performance of companies positively after controlling for firm size, age, leverage, physical capital intensity, market share, risk, industries and dummy year.

Practical implications
The study is of immense importance to corporate managers in improving managerial insight into the significance of investment in Intangible Assets. The results direct Indian managers to understand and realize the importance of Intangible Assets and keenly invest in research and development, technology, software, advertising, customer relationship management and human resources to further augment their performance.

Originality/value
Specifically considering India, the research related to the association between Intangible Assets and performance is undersized. Thus, the present study would contribute to the existing literature comprehensively.
Scope for alternative avenues to promote financial access to MSMEs in developing nation evidence from India
Authors: Maiti Moinak 
Published: July 2018

Purpose
The purpose of this study is to highlight the key challenges and opportunities that lie with some of the alternative avenues/tools to promote financial access to MSME in India.

Design/methodology/approach
Initially, the study discusses the scope of various alternative avenues/tools for MSME financing along with traditional bank SME credits, highlighting some of the factors that will boost the high performance and growth of MSME in future.

Findings
There is a dominance of domestic banks in the MSME financing over cross-border banks in India. The study finds several opportunities lie in the MSME financing for the banks and other alternative avenues/tools: friendly government policies and improving the legal system make the business environment suitable for MSME financing business. There are several obstacles like discrete presence of clients, high operating cost and low profitability, lack of proper risk management and low literacy rate that make MSME financing difficult for the SME finance business. Active government initiatives and other supporting factors will act as the game changer and promoter for the banks and other alternative avenues/tools for MSME financing.

Originality/value
The paper is original and brings out some valuable findings that will help the SME business clients to choose alternative access to finance.
Student internships within an information consulting practice: a case study of taxonomy design
Authors: Tucker Virginia M. , Dale Jonathan , Egge Vaughn , Fullman Ellie 
Published: July 2018

Purpose
This paper reports on a taxonomy design project involving graduate students in information science (MLIS degree) working as intern-consultants under the guidance of an information science faculty member. The consulting team developed a taxonomy that would reflect current academic departmental structures and be used to optimise publisher tools for generating metrics and interpretive assessment.

Design/methodology/approach
In this case study, three students worked under the direction of a faculty member on a consulting team for a Silicon Valley company that provides business analytics to academic publishers. Tasked with designing a taxonomy of disciplinary knowledge to support the company’s analytical software tools, the students developed methods for environmental scans, vocabulary design, validation and taxonomy management for the project objectives.

Findings
The consulting experience proved to be highly beneficial for the students as an opportunity to take concepts learned in their coursework and apply them in practice. The project team delivered to the company the most detailed taxonomy of academic disciplines in the marketplace, along with recommendations for its maintenance and management for ongoing support of business objectives. The company was supportive throughout the internship programme, generating collaborative contributions from all stakeholders.

Originality/value
As more students earning an Master of Library and Information Science (MLIS) or similar degree move into a wide array of careers within business environments, internship experience through consulting can be an essential advantage to their preparation.
Case studies in humanitarian logistics research
Authors: Vega Diego 
Published: July 2018

PurposeConsidered a strong method for exploratory investigations, case study research has become part of the mainstream approach, particularly in the field of humanitarian logistics (HL) and supply chain management. Nevertheless, similar to other logistics and SCM-related fields, rigor is not at its best. The purpose of this paper is to propose a framework for crafting case study research in HL, based on an analysis of published case study-based research.Design/methodology/approachThe study classifies and compares the use of case studies in HL research, based on criteria developed from the methodology literature including purpose, type and volume of data, and type of analysis.FindingsWhile case studies become more frequent, the results point out a lack of rigor, particularly regarding chain of evidence and the use of frameworks for case study rationale and analysis.Research limitations/implicationsThe study proposes a framework for case study design, based on four “check questions” that can help researchers to go through the process of crafting a case study.Practical implicationsThe study provides practitioners with more understanding of case studies in HL research, which they can use when calling for or evaluating such studies in their organizations.Originality/valueThis paper offers an initial framework for conducting case studies in HL.
Identifying Industry 4.0 IoT enablers by integrated PCA-ISM-DEMATEL approach
Authors: Rajput Shubhangini , Singh Surya Prakash 
Published: July 2018

Purpose
The purpose of this paper is to identify, analyze and model Internet of Things (IoT) enablers essential for the success of Industry 4.0.

Design/methodology/approach
IoT enablers for Industry 4.0 are identified from literature and inferable discussions with industry experts. Three different techniques namely, principal component analysis (PCA), interpretive structural modeling (ISM) and decision making trial and evaluation laboratory (DEMATEL) are applied to model IoT enablers. In addition to this, DEMATEL is also applied under two different situations representing the behavioral characteristic of experts involved. These are termed as optimistic (maximum) and pessimistic (minimum).

Findings
The integrated approach of PCA-ISM-DEMATEL shows that IoT ecosystem and IoT Big Data are the most influential or driving IoT enablers. These two enablers have been identified as the pillars for Industry 4.0. On the other side, IoT interchangeability, consumer IoT, IoT robustness and IoT interface and network capability have also been identified as the most dependent enablers for Industry 4.0.

Practical implications
The findings enable the industry practitioners to select the most appropriate driving enablers for an effective implementation of Industry 4.0.

Originality/value
The integrated approach-based hierarchical model and cause-effect relationship among IoT enablers are proposed which is a novel initiative for Industry 4.0. Moreover, two different variants of DEMATEL namely, pessimistic and optimistic are applied first time.