bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Trial of Autologous Filgrastim-Primed Bone Marrow Transplantation Versus Filgrastim-Mobilized Peripheral Blood Stem Cell Transplantation in Lymphoma Patients
Authors: Damiani Daniela , Fanin Renato , Silvestri Federico , Grimaz Stefania , Infanti Laura , Geromin Antonella , Cerno Michela , Michieli Mariagrazia , Rinaldi Cristina , Savignano Chiara , Trani Gabriella , Fiacchini Mauro , Baccarani Michele 
Published: October 2019

Abstract
Although a large amount of data is available on the effects of filgrastim (granulocyte colony-stimulating factor [G-CSF]) on the mobilization of stem cells in the circulation, data concerning its effects on bone marrow (BM) harvesting is scarce and controversial. We have designed a randomized trial comparing filgrastim-mobilized peripheral blood stem cell (PBSC) transplantation with filgrastim-primed autologous bone marrow transplantation (ABMT). Fifty-five patients affected by non-Hodgkin's (n = 38) or Hodgkin's (n = 17) lymphoma, selected for autologous transplantation over a 12-month period in a single institution, were randomized 2:1 to undergo BM or PB harvest/collection after priming for 3 days with filgrastim, 16 μg/kg body weight daily subcutaneously. BM priming with G-CSF allowed the harvest of a significantly higher number of mononuclear cells (MNC) (0.53 × 108/kg, range, 0.32 to 1.40), as compared with a historical control of unprimed BM harvests (0.43 × 108 MNC/kg, range, 0.15 to 0.72, P = .001). After high-dose ablative therapy, median time to neutrophil recovery above 0.5 × 109/L was 12 days for BM and 11 days for PB (P = .219); median time to platelet recovery above 20 × 109/L was 13 days for BM and 11 days for PB (P = .242). The same number of red blood cells, platelet transfusions, and posttransplant G-CSF doses were required in the two groups of patients. Less patients (50% v 70%) became febrile in the group transplanted with mobilized PB, but days of fever/patient and days on antibiotics were overlapping. The median time spent in the hospital after reinfusion was 16.5 and 15.5 days after primed BM and primed PB, respectively (P = .134). These data suggest that in patients with lymphoma submitted to autologous transplantation, the reinfusion of filgrastim-primed BM or filgrastim-mobilized PB leads to similar results, with an advantage of only 1 day in the neutrophil recovery and 1 day on the time spent in the hospital in favor of primed PB. Either option can be chosen on the basis of the availability of a surgery room or cell separator facilities and considering the patients' characteristics and wishes.
Inhibition of Human Breast Carcinoma Growth by a Soluble Recombinant Human CD40 Ligand
Authors: Hirano Akio , Longo Dan L. , Taub Dennis D. , Ferris Douglas K. , Young Lawrence S. , Eliopoulos Arisitides G. , Agathanggelou Angelo , Cullen Nicky , Macartney James , Fanslow William C. , Murphy William J. 
Published: October 2019

Abstract
CD40 is present on B cells, monocytes, dendritic cells, and endothelial cells, as well as a variety of neoplastic cell types, including carcinomas. CD40 stimulation by an antibody has previously been demonstrated to induce activation-induced cell death in aggressive histology human B-cell lymphoma cell lines. Therefore, we wanted to assess the effects of a recombinant soluble human CD40 ligand (srhCD40L) on human breast carcinoma cell lines. Human breast carcinoma cell lines were examined for CD40 expression by flow cytometry. CD40 expression could be detected on several human breast cancer cell lines and this could be augmented with interferon-γ. The cell lines were then incubated with a srhCD40L to assess effects on in vitro growth. srhCD40L significantly inhibited the proliferation of the CD40+ human breast cancer cell lines. This inhibition could also be augmented with interferon-γ. Viability was also affected and this was shown to be due to increased apoptosis of the cell lines in response to the ligand. Treatment of tumor-bearing mice was then performed to assess the in vivo efficacy of the ligand. Treatment of tumor-bearing SCID mice with the ligand resulted in significant increases in survival. Thus, CD40 stimulation by its ligand directly inhibits human breast carcinoma cells in vitro and in vivo. These results suggest that srhCD40L may be of clinical use to inhibit human breast carcinoma growth.
Low-protein diets supplemented with casein hydrolysate favor the microbiota and enhance the mucosal humoral immunity in the colon of pigs
Authors: Wang Huisong , Shen Junhua , Pi Yu , Gao Kan , Zhu Weiyun 
Published: October 2019

Abstract

Background
High-protein diets can increase the colonic health risks. A moderate reduction of dietary crude-protein (CP) level can improve the colonic bacterial community and mucosal immunity of pigs. However, greatly reducing the dietary CP level, even supplemented with all amino acids (AAs), detrimentally affects the colonic health, which may be due to the lack of protein-derived peptides. Therefore, this study evaluated the effects of supplementation of casein hydrolysate (peptide source) in low-protein (LP) diets, in comparison with AAs supplementation, on the colonic microbiota, microbial metabolites and mucosal immunity in pigs, aiming to determine whether a supplementation of casein hydrolysate can improve colonic health under very LP level. Twenty-one pigs (initial BW 19.90 ± 1.00 kg, 63 ± 1 days of age) were assigned to three groups and fed with control diet (16% CP), LP diets (13% CP) supplemented with free AAs (LPA) or casein hydrolysate (LPC) for 4 weeks.

Results
Compared with control diet, LPA and LPC diet decreased the relative abundance of Streptococcus and Escherichia coli, and LPC diet further decreased the relative abundance of Proteobacteria. LPC diet also increased the relative abundance of Lactobacillus reuteri. Both LP diets decreased concentrations of ammonia and cadaverine, and LPC diet also reduced concentrations of putrescine, phenol and indole. Moreover, LPC diet increased total short-chain fatty acid concentration. In comparison with control diet, both LP diets decreased protein expressions of Toll-like receptor-4, nuclear factor-κB, interleukin-1β and tumor necrosis factor-α, and LPC diet further decreased protein expressions of nucleotide-binding oligomerization domain protein-1 and interferon-γ. LPC diet also increased protein expressions of G-protein coupled receptor-43, interleukin-4, transforming growth factor-β, immunoglobulin A and mucin-4, which are indicators for mucosal defense activity.

Conclusions
The results showed that supplementing casein hydrolysate showed beneficial effects on the colonic microbiota and mucosal immunity and barrier function in comparison with supplementing free AAs in LP diets. These findings may provide new framework for future nutritional interventions for colon health in pigs.
First report of the entomopathogenic nematode, Steinernema carpocapsae, from Moghan region of Iran and its efficacy against the turnip moth, Agrotis segetum Denis and Schiffermuller (Lepidoptera: Noctuidae), larvae
Authors: Ebrahimi Laleh , TanhaMaafi Zahra , Sharifi Parviz 
Published: October 2019

Abstract
During a survey of entomopathogenic nematodes (EPNs) in Moghan region of Iran in 2015, a steinernematid species was isolated, using the Galleria-baiting method. Based on its morphological and phylogenetic analysis of molecular data, the isolate was identified as Steinernema carpocapsae. The ITS rDNA sequence was deposited in NCBI (National Center for Biotechnology Information) with accession number of MF187616.1. Nucleotide row data was edited, using MEGA 6.0 software, and homologous sequences were involved in analysis, using Blast software. Sequences were aligned using Clustal W. Bootstrap analysis. The phylogenetic tree was constructed by the maximum likelihood method, using MEGA 6.0 software, and Steinernema feltiae was used as out-group. The turnip moth, Agrotis segetum Denis and Schiffermuller (Lepidoptera: Noctuidae), is one of the most important and destructive cutworm pests in Moghan. Therefore, the lethal effect of S. carpocapsae isolate Moghan (IRMoghan) was evaluated in a soil assay against the last instar larvae of A. segetum under laboratory conditions. The bioassay results showed high susceptibility of the larvae to S. carpocapsae. The LC10, LC50, and LC90 values were 9.9, 54.13, and 246.2 IJs (infective juveniles) per larva of the pest, respectively (χ2 = 7.36; df = 3, P value = 0.061). Reproduction of the EPNs within the dissected cadavers was observed. The bioassay results indicated that the new isolate is a promising biocontrol agent against A. segetum larvae with success recycling through them.
Intraparenchymal supratentorial arachnoid cyst: a case report
Authors: Dlaka Domagoj , Raguž Marina , Muller Danko , Romić Dominik , Almahariq Fadi , Dlaka Jelena , Kaštelančić Anđelo , Chudy Darko 
Published: October 2019

Abstract

Background
Intracranial arachnoid cysts are collections of cerebrospinal fluid within the arachnoid membrane and subarachnoid space of the cisterns and major cerebral fissures that account for about 1% of all intracranial lesions. Expansion of the cyst and compression on surrounding structures may became symptomatic, which reflects its size and anatomic distribution.

Case presentation
Here, we present a very rare case of patient with supratentorial intraparenchymal arachnoid cyst placed in the left frontal lobe without any communication with the subarachnoid space and ventricle and presented with clinical symptoms. The patient underwent fenestration of the lesion and was clinically improved.

Conclusions
Although the etiology and the enlargement mechanism of arachnoid cysts remain unclear, both conservative and surgical treatments are optional. According to size, anatomical location, neuroimaging, and clinical symptoms, an arachnoid cyst should be included in the differential diagnosis of primary intracerebral cysts.
Building an Infrastructure and Standard Methodology for Actively Engaging Patients in Advance Care Planning
Authors: Stepan Karen , Bashoura Lara , George Marina , Griffith Wendy , Meyer Margaret , Nortjé Nico , Price Kristen , Zhukovsky Donna S. , Rodriguez Maria Alma 
Published: October 2019

PURPOSE: With little to no infrastructure or standardized methodology in place to actively engage patients in advance care planning (ACP), The University of Texas MD Anderson Cancer Center set out to identify needed resources, develop an intervention to improve ACP, and evaluate the intervention’s effects. METHODS: With the support of executive leadership, a multidisciplinary workgroup enlisted the support of ACP champions, performed a root-cause analysis, developed a detailed ACP process flow by provider role, developed patient and family education resources, and developed faculty and staff training materials. The workgroup also implemented two Plan-Do-Study-Act intervention cycles, which identified difficulty using the ACP note function in our electronic health record (EHR) as a barrier to ACP adoption. By educating patients, families, and providers and improving the EHR’s functionality, the workgroup aimed to increase the percentage of ambulatory patients with a diagnosis of advanced or metastatic cancer who had a documented ACP conversation with a provider by their third office visit. Our goal was to improve this percentage from 20% at baseline to 50% after the intervention. Data were obtained from our institution’s EHRs. RESULTS: The percentage of patients who had documented ACP conversations increased from 20% at baseline to 34% at the end of fiscal year 2017 and 54% at the end of fiscal year 2018. CONCLUSION: Owing to the dedicated efforts of many individuals across the institution, the postintervention goal was surpassed. Additional efforts to facilitate ACP conversations are ongoing.
Spine Injuries in Soccer
Authors: Plais Nicolas , Salzmann Stephan N. , Shue Jennifer , Sanchez Carlos Diez , Urraza Fabian J. , Girardi Federico P. 
Published: October 2019

Abstract
Soccer is the most popular sport in the world, with more than 270 million participants. It is characterized by repetition of short and intense actions that require high-coordination capacity. It is a sport where interactions with other players put the athletes at risk for traumatic injuries. Lower-limb injuries are the most prevalent injuries in soccer. Spine injuries are less frequent; however, they can impose serious and debilitating sequelae on the athlete. These injuries can be associated with long recovery periods preventing return to play. Moreover, specific repetitive activities (heading, kicking, etc.) can lead to chronic injuries. The cervical spine is particularly at risk for degenerative changes. Considerations for when an athlete should undergo spinal surgery and the timing of return to play present a difficult challenge to spine specialists. The objective of this article is to review the epidemiology, diagnosis, treatment, and prevention of spinal injuries in soccer.
MRI evaluation of extramural vascular invasion by inexperienced radiologists
Authors: Wang Shuai , Li Xiao-Ting , Zhang Xiao-Yan , Sun Rui-Jia , Qu Yu-Hong , Zhu Hui-Ci , Guan Zhen , Sun Ying-Shi 
Published: October 2019

Objective:
We proposed to determine whether the performance of inexperienced radiologists in determining extramural vascular invasion (EMVI) in rectal cancer on MRI can be promoted by means of targeted training.

Methods:
230 rectal cancer patients who underwent pre-operative chemoradiotherapy were included. Pre-therapy and post-therapy MR images and pathology EMVI evaluation were available for cases. 230 cases were randomly divided into 150 training cases and 80 testing cases, including 40 testing case A and 40 testing case B. Four radiologists were included for MRI EMVI evaluation, who were divided into targeted training group and non-targeted training group. The two groups evaluated testing case A at baseline, 3 month and 6 month, evaluated testing case B at 6 month. The main outcome was agreement with expert-reference for pre-therapy and post-therapy evaluation, the other outcome was accuracy with pathology for post-therapy evaluation.

Results:
After 6 months of training, targeted training group showed statistically higher agreement with expert-reference than non-targeted training group for both pre-therapy and post-therapy MRI EMVI evaluation of testing case A and testing case B, all p &lt; 0.05. Targeted training group also showed significantly higher accuracy with pathology than non-targeted training group for post-therapy evaluation of testing case A and testing case B after 6 months of training, all p &lt; 0.05.

Conclusion:
The diagnostic performance for MRI EMVI evaluation could be promoted by targeted training for inexperienced radiologist.

Advances in knowledge:
This study provided the first evidence that after 6 month targeted training, inexperienced radiologists demonstrated improved diagnostic performance, with a 20% increase in agreement with expert-reference for both pre-therapy and post-therapy MRI EMVI evaluation and also a 20% increase in or accuracy with pathology for post-therapy evaluation, while inexperienced radiologists could not gain obvious improvement in MRI EMVI evaluation through the same period of regular clinical practice. It indicated that targeted training may be necessary for helping inexperienced radiologist to acquire adequate experience for the MRI EMVI evaluation of rectal cancer, especially for radiologist who works in a medical unit where MRI EMVI diagnosis is uncommon.
Business Models for Technology-Intensive Supply Chains
Authors: Lee Junghee , Krishnan Vish , Shin Hyoduk 
Published: October 2019

Technology and intellectual property play increasingly critical roles in emerging supply chains by endowing products with sought-after capabilities. In such technology-intensive supply chains, the technology invented by an upstream firm must be embedded in a subsystem that is then integrated into a full system. The technology providers’ prevalent royalty-driven business model has gotten complicated in this multilateral supply chain, prompting formal research attention. Moreover, providers also consider forward integration into manufacturing to monetize their intellectual property. We characterize the appropriateness of different business model decisions for markets, which may have varying levels of consumer diversity and competitive intensity at intermediate layers. For the technology provider, our key results show that a subsystem base royalty approach is the optimal business model when dealing with monopolistic intermediaries or having a low degree of consumer diversity. However, a full-system base royalty business model becomes increasingly optimal when the intermediate supply chains face competition and consumer diversity increases. We present conditions under which the technology provider may want to forward integrate. Our formulation and results are relevant to technology providers, policy makers, and industry groups engaged in the prevailing heated global discussion on royalty base. This paper was accepted by Serguei Netessine, operations management.
Do Director Networks Matter for Financial Reporting Quality? Evidence from Audit Committee Connectedness and Restatements
Authors: Omer Thomas C. , Shelley Marjorie K. , Tice Frances M. 
Published: October 2019

This study examines the effect of audit committee connectedness through director networks on financial reporting quality, specifically the misstatement of annual financial statements. Using network analysis, we examine multiple dimensions of connectedness and find that after controlling for operating performance and corporate governance characteristics, firms with well-connected audit committees are less likely to misstate annual financial statements. In addition, our study demonstrates that audit committee connectedness through director networks moderates the negative effect of board interlocks to misstating firms on financial reporting quality. We conduct several tests to address identification concerns and find similar results. Our findings suggest that firms with better-connected audit committees are less likely to adopt reporting practices that reduce financial reporting quality. This paper was accepted by Suraj Srinivasan, accounting.
Reflexões sobre a (des) inserção da mineração de areia no Plano Diretor do município de Campinas-SP: há como mudar esta realidade?
Authors: Fulfule Elaine Cristina , Longo Regina Marcia , Mastrodi Josué 
Published: October 2019

Trata este trabalho de analisar a legislação minerária relativa a areia, trazendo a discussão da carência de diplomas legais nesta área no Brasil, no Estado de São Paulo e no município de Campinas, SP. O tema é analisado a partir das questões relativas ao equacionamento do uso e ocupação do solo, haja vista que a mineração compete principalmente com a construção civil e a agropecuária pelo uso do solo. Para subsidiar a argumentação, foi analisado o Plano Diretor do município de Campinas, bem como foi realizada uma revisão bibliográfica sobre os temas na base de periódicos da Capes, e uma revisão da normatização existente sobre os temas mineração de areia e ocupação do solo. Identificou-se uma acentuada deficiência do Plano Diretor do município analisado no que toca à previsão de ocupação do solo pela mineração de areia, posto não haver, no referido Plano, nenhuma priorização no que diz respeito ao manejo sustentável da mineração de areia, que é minério de largo uso na construção civil. A proposta feita para equacionar esta deficiência é envolver os demais municípios da região metropolitana de Campinas na produção deste minério.
The daily rhythm of secretion of adrenocorticotropic hormone in assessing the adequacy of replacement therapy for primary chronic adrenal insufficiency
Authors: Fadeev V. V. , Gitel E. P. , Melnichenko G. A. 
Published: October 2019

Plasma level о] АС 1Н was radioimmunoassayed every 4 hours for 24 h in three groups of patients in order to evaluate the possibility of using circadian rhythm of ACTH secretion for assessment of the efficacy of substitute glucocorticoid therapy for primary chronic adrenal insufficiency (CAI-1, Addison’s disease). In group 1 (n = 14) patients with CAI-1 were treated with prednisolone (5 mg at 9.00 and 2.5 mg at 14.00), in group 2 dexamethasone (0.5 mg at 23.00) and prednisolone (2.5 mg at 14.00). In addition, all patients with CAI-1 were administered 9a-fluorocortisol in a daily dose of0.005-0.01 mg. Control group consisted of 14 healthy volunteers.
The level of A CTH varied within a wide range in both variants of substitute therapy in comparison with the norm. The areas under the curve reflecting ACTH concentrations within 24h differed negligibly in groups 1 and 2 and in group 2 and control. The area under ACTH curve in group 1 was significantly larger than in the control. The mean concentrations of ACTH in group I at 7.00 and 11.00 were significantly higher than in the two other groups. In general, circadian rhythms of ACTH secretion were closer to the norm in the patients treated with dexamethasone. According to our clinical experience, dexamethasone had to be discontinued because of the overdosage syndrome (body weight excess, high appetite and insomnia) in at least 2/3 of patients initially prescribed this agent, and therefore we conclude that the clinical picture and data on the 24-h rhythm of A CTH secretion disagree. Evaluating the results of substitute therapy for CAI-1, one should remember that normal rhythm of ACTH secretion during 24 h does not rule out overdosage of glucocorticoids, and therefore the results of laboratory tests should be interpreted with due consideration for the clinical picture.
La « carte d’Artémidore » ? Le delta des Ptolémées!
Authors: Carrez-Maratray Jean-Yves 
Published: October 2019

Abstract
As some scholars have already suggested, the « Artemidorus map » does not depict a Spanish landscape, but a huge river delta. This article argues in favour of the Nile delta in Ptolemaic times. The three main river courses at the centre of the map correspond exactly to what Ps.Skylax (340 BC) called the « Sebennytic », « Mendesian » and « Phatnitic » mouths (stomata). Some peculiarities, like the Bubastis island and the Red Sea canal, seem to confirm this identification.
Two Coptic Prayers on Ostracon (P.Berol. 709 and 9444+4790)
Authors: Mihálykó Ágnes T. 
Published: October 2019

Abstract
Edition, with philological and liturgical commentary, of two Theban 7th/8th century liturgical prayers in Sahidic Coptic from the Berlin Papyrus Collection. The first prayer is an unattested redaction of the intercession for peace, related to the wording of the anaphora of St. Mark. The second is a long and elaborate prayer of thanksgiving, asking for protection. It parallels the first prayer of the morning of the present-day Coptic rite.
Whence Diyār Bakr? An Inquiry into Early Jazīran Administrative Geography
Authors: Hagemann Hannah-Lena 
Published: October 2019

Abstract
This article discusses the emergence of Diyār Bakr as the northern subdivision of the Jazīra in the early Islamic period. It shows that this sub-province is a product of the 10th century CE and not, as has hitherto been assumed, of the conquest or Umayyad period. As a first step, the paper traces the appearance of the name Diyār Bakr in the Arabic sources to the mid-10th century. It then turns to the ʿAbbāsid geographical tradition and gives an overview of the various portrayals of the region of the Jazīran north up to al-Muqaddasī (d. after 990), who is the first to provide a rudimentary depiction of the Jazīran north as ‘Diyār Bakr’. The article then turns to the history of the Banū Shaybān of Bakr/Rabīʿa in the Jazīran north to offer a tentative explanation for the origin of the term and administrative district of Diyār Bakr. It concludes with a brief discussion of the need to re-evaluate the political and administrative history of the Jazīra before the 10th century.