bluuebunny/crossref_metadata_2025_split huggingface dataset:
Het vernieuwde toezicht in het onderwijs
Authors: Honingh Marlies , Ehren Melanie , van Montfort Cor 
Published: December 2018

The renewed work approach of the Netherlands Inspectorate of education
This paper presents the policy theory of the Dutch Inspectorate of Education’s 2017 framework. The framework includes a set of indicators and working methods for the inspections of school boards which are expected to lead to improved quality and organizational learning of the schools and colleges within each board’s portfolio. Inspection feedback, quality assurance, stakeholder involvement and governance are the key mechanisms through which customized inspections are assumed to affect change. These customized inspections start from a set of legal requirements schools and colleges have to meet, but add inspections modules which are agreed on with each school board at the start of an inspection visit. As these inspections are currently being implemented, there is no evidence yet on the validity of these assumptions.
Diversiteit in bestuurskundig perspectief
Authors: Çelik Saniye 
Published: December 2018

Diversity from the perspectve of public adminstration
In practice, diversity interventions do not always appear to be effective. One argument is that there is little or no match between the perspectives of public organizations on diversity and the interventions used. This article provides an overview of the underlying rationales for diversity policy and discusses the perspectives on diversity from the diversity literature, HRM, and management literature and how these overlap, complement each other and differ from each other. What these perspectives have in common is that they all emphasize the added value of diversity. In the diversity literature, the emphasis is on the four perspectives equality, legitimacy, creativity, and the labour market. HRM literature focusses on managing differences. In public administration, there is a shift from active representation by individuals to connecting by all employees. Furthermore, the binding perspective is gaining more and more importance in the public domain because it may be possible to close the gap between the government and its citizen. This perspective emphasizes the importance of the long-term relationship with citizens to strengthen the trust of citizens in the government for realizing social tasks and responsibilities. It makes diversity an issue for all employees. For Hassan and Havva, and also for Hans and Hanna.
De tweeconclusieregel en beginselen van burgerlijk procesrecht
Authors: Kroes Frank 
Published: December 2018

De tweeconclusieregel en beginselen van burgerlijk procesrecht
Beginselen van behoorlijk procesrecht nemens sinds de dagen van Van Boneval Faure een plaats in in het burgerlijk procesrecht en winnen nog steeds aan belang. Aan de tweeconclusieregel, die de mogelijkheden om de rechtsstrijd in hoger beroep te wijzigen of uit te breiden aan banden legt, liggen met name de beginselen ten grondslag van toegang tot de rechter, hoor en wederhoor, berechting binnen een redelijke termijn en de partijautonomie. Ook de uitzonderingen op de regel laten zich goed verklaren uit beginselen van behoorlijk procesrecht.
Home-based service for enzyme replacement therapy in lysosomal storage disorders: patient reported outcomes
Authors: Tirelli Paolo , Giona Fiorina , Di Rocco Maja , Cassinerio Elena , Pisani Antonio , Pieruzzi Federico , Veroux Massimiliano , Giudici Gino Alberto , Cipriani Filippo 
Published: December 2018

Background: Lysosomal storage diseases (LSDs) are a heterogeneous group of rare chronic genetic conditions. The standard-of-care treatment for LSDs is hospital-based infusion of enzyme replacement therapy (ERT), however, over time this can be stressful and inconvenient. The Italian TuTor program, established in 2011 by Sanofi Genzyme, is a professional nursing service providing home-based ERT to patients with LSDs.Objectives: The current questionnaire-based study was conducted to investigate the level of patient satisfaction with theTuTor program and to shed light on disease perception.Methods: Patients were enrolled in the TuTor program from 2011 onwards. The first 100 patients enrolled were interviewed at baseline with follow-up interviews conducted at 6, 12 and 18 months.Results: Overall, 52 patients were female; 46 had Gaucher’s disease, 46 had Fabry disease and 8 had mucopolysaccharidosis type 1. Patients took on average >2 hours to receive hospital-based ERT, plus time associated with the infusion; 2 out of 3 patients needed a caregiver to travel to the hospital. After receiving home-based ERT for 6 months, 37% of patients considered their quality of life ‘greatly improved’ (60% at 18 months). Overall, 99% to 100% of patients rated the home-based nursing service as ‘positive’ or ‘very positive’ and reported that they would recommend the service to other patients with their condition.Conclusions: For patients with LSDs eligible for ERT, a disease-specific home-based nursing service increased their perception of quality of life over a hospital-based service and was advantageous in terms of their time and expenditure.
Učitelská self-efficacy při práci s dětmi-cizinci v širších souvislostech
Authors: Záleská Klára , Leix Alicja 
Published: December 2018

Předkládaná studie se zabývá tématem self-efficacy učitelů českých základních škol v práci s dětmi-cizinci a faktory, které ji ovlivňují. Odpověď na výzkumnou otázku, jaká je self-efficacy učitelů v této oblasti, jsme získávaly pomocí analýzy polostrukturovaných rozhovorů s učiteli s různě velkou zkušeností s výukou dětí-cizinců. Výpovědi učitelů jsme analyzovaly mj. s přihlédnutím k základním bodům charakterizujícím chování učitele s vysokým self-efficacy, které jsme sestavily na základě rešerše odborné literatury. Šetření ukázalo řadu faktorů, které hrají roli v tom, jak učitel vnímá svou schopnost práce s dětmi-cizinci, mj. to, že důležitou roli hraje míra zkušeností učitelů s výukou cizinců. Self-efficacy učitelů negativně ovlivňují jejich obavy, a to především obavy z práce s dětmi s nulovou znalostí českého jazyka a s dětmi pocházejícími ze vzdálených kultur. Dotazovaní sami poukazují na možné způsoby, jak zvýšit svou self-efficacy v diskutovaných oblastech. Mezi návrhy jsou např. přípravné třídy pro děti-cizince bez znalosti češtiny či posílení vzdělávání učitelů v několika konkrétních oblastech týkajících se praktických aspektů práce v kulturně nehomogenní třídě.
“One Belt One Road” and Central Asia: A New Trend in Internationalization of Higher Education?
Authors: Li Aisi 
Published: December 2018

China’s One Belt One Road (OBOR) strategy is the latest trend in international relations, and it is making a real impact on higher education in Central Asia. This article discusses the impact of three aspects of the plan: Chinese funding for study abroad, the Confucius Institutes, and the role of Xinjiang, China’s northwestern frontier.
Creating National Champions in France: A Little Less Égalité, a Little More Sélectivité?
Authors: Highman Ludovic 
Published: December 2018

The merger between Paris–Sorbonne University (Paris IV) and Pierre and Marie Curie University (Paris VI) will create a single, multidisciplinary institution in the heart of Paris. This merger needs to be contextualized within the national and European contexts, in order to shed light on the drivers, opportunities, and challenges behind a trend that has become increasingly visible among European nations, which seek torationalize and consolidate their higher education systems.
Higher Education Leadership Training: Global Maps and Gaps
Authors: Rumbley Laura , Van't Land Hilligje , Becker Juliette 
Published: December 2018

Globally, most higher education leaders, managers, and policymakers receive no formal/specialized training for their work. Compared to the need, there is a relatively small number of structured training opportunities that exist to build leadership and management capacity in higher education around the world. These training programs are almost universally small in scale and largely unable to offer systematic accounts ofthe long-term impact of their efforts. This is a critical concern in the face of the myriad opportunities and imperatives facing higher education institutions and systems worldwide—particularly in low-income and emerging economy contexts—now and into the foreseeable future.
Predatory Conferences: A Case of Academic Cannibalism
Authors: McCrostie James 
Published: December 2018

The number of questionable conferences continues to increase around the world. Questionable conference organizers are companies that aim to profit as much as possible from the event by preying on researchers’ need to present research findings. They fail to perform any real peer review and deceive researchers to maximize profits. This essay outlines argues that the term questionable conference serves better than the more established predatory conference, criticizes complicit researchers, lists common red flags to identify questionable conferences and explains what might be done to solve the problem.
Gender and Higher Education: Increasing Exposure of Harassment and Pay Gaps
Authors: Hazelkorn Ellen 
Published: December 2018

In Ireland and the United Kingdom, public discourse around issues of sexual harassment and promotion and pay gaps is increasing. A lack of research, combined with a lack of understanding, means the full scale is unknown, and universities lack basic guidelines. Narrow definitions of excellence also shape academic culture. But action is slowly taking hold. The take-away is that nothing moves institutions fasterthan compliance and money.
An Agenda in Motion: Women’s Issues in Latin American Higher Education
Authors: Maldonado-Maldonado Alma , Acosta Felicitas 
Published: December 2018

Women in Latin America have experienced physical and psychological violence; discrimination; lack of equal opportunities; less recognition for their work, abilities, and capacities. The #MeToo and Time's Up movements (2017) are dealing with the issue of women's role in present-day society and highlight cases of male power towards women. This article offers a reflection on this discussion at universities in the region.
Stages et réalité des professionnelles et professionnels en santé et services sociaux dans un contexte francophone minoritaire à Iqaluit, au Nunavut
Authors: Mercure Dominique , Rivard Sylvie , Bélanger Roxanne , Charrier Marie-Josée 
Published: December 2018

Cet article présente la démarche d’analyse et les résultats d’une recherche sur les stages et la réalité des professionnelles et professionnels en santé et services sociaux dans un contexte francophone minoritaire en région arctique. Une démarche méthodologique d’étude de cas à multiples niveaux a été choisie pour permettre de comprendre le vécu des différents acteurs et actrices de la communauté francophone vivant à Iqaluit, au Nunavut. Douze entretiens ont été effectués auprès de stagiaires et de professionnelles et professionnels oeuvrant dans les services de santé et les services sociaux pour mieux saisir leur contexte de pratique, les défis rencontrés, les compétences développées dans ce milieu et les obstacles quant à l’organisation des stages. Les résultats illustrent les perceptions de participantes et participants non autochtones sur une réalité complexe composée de nombreux défis.
Des stages en français pour se préparer à travailler auprès des communautés francophones en situation minoritaire
Authors: Savard Jacinthe , Benoît Josée , Dubouloz Claire-Jehanne , Breau-Godwin Stéphanie 
Published: December 2018

Dans l’objectif d’augmenter le nombre de professionnelles et professionnels pouvant offrir des services sociaux et de santé en français dans les communautés francophones en situation minoritaire (CFSM), des stages en français ont été offerts à des étudiantes et étudiants bilingues de programmes de formation professionnelle offerts en anglais au sein d’universités canadiennes. L’expérience a été positive pour l’ensemble des parties prenantes : stagiaires, éducatrices-cliniciennes et responsables de la formation clinique. Après cette expérience, les stagiaires ont mentionné avoir une meilleure connaissance des défis d’accès aux services rencontrés par les CFSM et se sentir plus en mesure d’offrir des services en français à ces communautés.
Retrospective Analysis of Plantar Fascia by Ultrasound Imaging in Patients with Plantar Fasciitis
Authors: Slayton Michael Henry , Amodei Richard C. , Compton Keegan B. , Cicchinelli Luke D. 
Published: December 2018

Background:We compared diagnostic ultrasound images of the plantar fascia with available patient histories for symptomatic patients previously diagnosed as having plantar fasciitis. Plantar fascia thickness and depth, the prevalence of perifascial hypoechoic lesions, and injury timelines in patients were reviewed.Methods:Images and histories for 126 symptomatic patients were collected from a patient database. We documented plantar fascia depth and thickness and the visualization of hypoechoic perifascial lesions. After image analysis, the obtained plantar fascia thickness measurements were compared with various patient attributes for possible relationships, including age, weight, and body mass index. In addition, plantar fascia thickness measurements were separated based on injury timeline as well as symptomatic/asymptomatic foot for patients with unilateral conditions to check for significant differences between subgroups. These were, in turn, compared with a control group of 71 individuals with no heel pain or diagnosis of plantar fasciitis.Results:Overall, mean ± SD symptomatic thickness (n = 148) was 6.53 ± 1.56 mm. Mean ± SD symptomatic depth (n = 136) was 13.36 ± 2.14 mm. For the control group, mean ± SD thickness was 3.20 ± 0.66 mm and depth was 10.30 ± 2.00 mm. Comparison of thickness based on injury timeline showed two significant differences: acute injuries (≤3 months) are significantly thicker than chronic injuries (&gt;3 months), and only acute symptomatic thicknesses are significantly different from their asymptomatic thickness counterparts. Age, weight, and body mass index did not show significant correlations to thickness. Analysis of ultrasound images showed that 93% of symptomatic feet had hypoechoic lesions.Conclusions:Injury timeline and the presence of hypoechoic lesions may play important roles in patient discomfort, diagnosis, and treatment of plantar fasciitis.
Diversity of NC10 bacteria associated with sediments of submergedPotamogeton crispus(Alismatales: Potmogetonaceae)
Authors: Wang Binghan , Huang Shanshan , Zhang Liangmao , Zhao Jianwei , Liu Guanglong , Hua Yumei , Zhou Wenbing , Zhu Duanwei 
Published: December 2018

BackgroundThe nitrite-dependent anaerobic methane oxidation (N-DAMO) pathway, which plays an important role in carbon and nitrogen cycling in aquatic ecosystems, is mediated by “CandidatusMethylomirabilis oxyfera” (M. oxyfera) of the NC10 phylum.M. oxyfera-like bacteria are widespread in nature, however, the presence, spatial heterogeneity and genetic diversity ofM. oxyferain the rhizosphere of aquatic plants has not been widely reported.MethodIn order to simulate the rhizosphere microenvironment of submerged plants,Potamogeton crispuswas cultivated using the rhizobox approach. Sediments from three compartments of the rhizobox: root (R), near-rhizosphere (including five sub-compartments of one mm width, N1–N5) and non-rhizosphere (>5 mm, Non), were sampled. The 16S rRNA gene library was used to investigate the diversity ofM. oxyfera-like bacteria in these sediments.ResultsMethylomirabilis oxyfera-like bacteria were found in all three sections, with all 16S rRNA gene sequences belonging to 16 operational taxonomic units (OTUs). A maximum of six OTUs was found in the N1 sub-compartment of the near-rhizosphere compartment and a minimum of four in the root compartment (R) and N5 near-rhizosphere sub-compartment. Indices of bacterial community diversity (Shannon) and richness (Chao1) were 0.73–1.16 and 4–9, respectively. Phylogenetic analysis showed that OTU1-11 were classified into group b, while OTU12 was in a new cluster of NC10.DiscussionOur results confirmed the existence ofM. oxyfera-like bacteria in the rhizosphere microenvironment of the submerged plantP. crispus. Group b ofM. oxyfera-like bacteria was the dominant group in this study as opposed to previous findings that both group a and b coexist in most other environments. Our results indicate that understanding the ecophysiology ofM. oxyfera-like bacteria group b may help to explain their existence in the rhizosphere sediment of aquatic plant.
Genetic landscape and novel disease mechanisms from a large LGMD cohort of 4656 patients
Authors: Nallamilli Babi Ramesh Reddy , Chakravorty Samya , Kesari Akanchha , Tanner Alice , Ankala Arunkanth , Schneider Thomas , da Silva Cristina , Beadling Randall , Alexander John J. , Askree Syed Hussain , Whitt Zachary , Bean Lora , Collins Christin , Khadilkar Satish , Gaitonde Pradnya , Dastur Rashna , Wicklund Matthew , Mozaffar Tahseen , Harms Matthew , Rufibach Laura , Mittal Plavi , Hegde Madhuri 
Published: December 2018

AbstractObjectiveLimb‐girdle muscular dystrophies (LGMDs), one of the most heterogeneous neuromuscular disorders (NMDs), involves predominantly proximal‐muscle weakness with >30 genes associated with different subtypes. The clinical‐genetic overlap among subtypes and with other NMDs complicate disease‐subtype identification lengthening diagnostic process, increases overall costs hindering treatment/clinical‐trial recruitment. Currently seven LGMD clinical trials are active but still no gene‐therapy‐related treatment is available. Till‐date no nation‐wide large‐scale LGMD sequencing program was performed. Our objectives were to understand LGMD genetic basis, different subtypes’ relative prevalence across US and investigate underlying disease mechanisms.MethodsA total of 4656 patients with clinically suspected‐LGMD across US were recruited to conduct next‐generation sequencing (NGS)‐based gene‐panel testing during June‐2015 to June‐2017 in CLIA‐CAP‐certified Emory‐Genetics‐Laboratory. Thirty‐five LGMD‐subtypes‐associated or LGMD‐like other NMD‐associated genes were investigated. Main outcomes were diagnostic yield, gene‐variant spectrum, and LGMD subtypes’ prevalence in a large US LGMD‐suspected population.ResultsMolecular diagnosis was established in 27% (1259 cases; 95% CI, 26–29%) of the patients with major contributing genes to LGMD phenotypes being: CAPN3(17%), DYSF(16%), FKRP(9%) and ANO5(7%). We observed an increased prevalence of genetically confirmed late‐onset Pompe disease, DNAJB6‐associated LGMD subtype1E and CAPN3‐associated autosomal‐dominant LGMDs. Interestingly, we identified a high prevalence of patients with pathogenic variants in more than one LGMD gene suggesting possible synergistic heterozygosity/digenic/multigenic contribution to disease presentation/progression that needs consideration as a part of diagnostic modality.InterpretationOverall, this study has improved our understanding of the relative prevalence of different LGMD subtypes, their respective genetic etiology, and the changing paradigm of their inheritance modes and novel mechanisms that will allow for improved timely treatment, management, and enrolment of molecularly diagnosed individuals in clinical trials.
Micro/Nanometer‐Structured Scaffolds for Regeneration of Both Cartilage and Subchondral Bone
Authors: Deng Cuijun , Lin Rongcai , Zhang Meng , Qin Chen , Yao Qingqiang , Wang Liming , Chang Jiang , Wu Chengtie 
Published: December 2018

AbstractTreatment of osteochondral defects remains a great challenge in clinical practice because cartilage and subchondral bone possess significantly different physiological properties. In this study, the controlled surface micro/nanometer structure of bioactive scaffolds in a combination of biomaterial chemistry is harnessed to address this issue. Model bioactive biomaterials, bredigite (BRT) scaffolds, with controlled surface micro/nanostructure are successfully fabricated by combining 3D printing with a hydrothermal process. It is found that the growth of micro/nano–calcium phosphate crystals on the surface of BRT scaffolds notably enhances their compressive strength by healing the microcracks on the strut surface. The micro/nanostructured surface distinctly facilitates the spread and differentiation of chondrocytes by activating integrin αvb1 and α5b1 heterodimers, regulates cell morphology, and promotes osteogenic differentiation of rabbit bone marrow stromal cells (rBMSCs) through the synergetic effect of integrin α5b1 and RhoA, in which the microrod surface demonstrates the highest stimulatory effect on the differentiation of chondrocytes and rBMSCs. The in vivo study shows that the micro/nanostructured surface of the 3D printed scaffolds obviously promotes the regeneration of both cartilage and subchondral bone tissues. This study suggests that the construction of controlled micro/nanostructured surface in porous 3D scaffolds offers a smart strategy to induce bilineage bioactivities for osteochondral regeneration.
Supramolecular Antibacterial Materials for Combatting Antibiotic Resistance
Authors: Li Xingshu , Bai Haotian , Yang Yuchong , Yoon Juyoung , Wang Shu , Zhang Xi 
Published: December 2018

AbstractAntibiotic‐resistant bacteria have emerged as a severe threat to human health. As effective antibacterial therapies, supramolecular materials display unprecedented advantages because of the flexible and tunable nature of their noncovalent interactions with biomolecules and the ability to incorporate various active agents in their platforms. Herein, supramolecular antibacterial materials are discussed using a format that focuses on their fundamental active elements and on recent advances including material selection, fabrication methods, structural characterization, and activity performance.
Repurposed Leather with Sensing Capabilities for Multifunctional Electronic Skin
Authors: Zou Binghua , Chen Yuanyuan , Liu Yihan , Xie Ruijie , Du Qinjie , Zhang Tao , Shen Yu , Zheng Bing , Li Sheng , Wu Jiansheng , Zhang Weina , Huang Wei , Huang Xin , Huo Fengwei 
Published: December 2018

AbstractElectronic skin (e‐skin), an important part toward the realization of artificial intelligence, has been developing through comprehending, mimicking, and eventually outperforming skin in some aspects. Most of the e‐skin substrates are flexible polymers, such as polydimethylsiloxane (PDMS). Although PDMS was found to be biocompatible, it is not suitable for long‐time wearing due to its air impermeability. This study reports a simple and designable leather based e‐skin by merging the natural sophisticated structure and wearing comfort of leather with the multifunctional properties of nanomaterials. The leather based e‐skin could make leather, “the dead skin,” repurposed for its sensing capabilities. This e‐skin can be applied in flexible pressure sensors, displays, user‐interactive devices, etc. It provides a new class of materials for the development of multifunctional e‐skin to mimic or even outshine the functions of real skin.