bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors associated with loss of hepatitis B virus surface antibody in patients with HBV surface-antigen negative/surface antibody positive serostatus receiving biologic DMARDs to treat rheumatic diseases – a nested case-control study
Authors: Hung Ming-Hui , Tien Ya-Chih , Chiu Ying-Ming 
Published: June 2019

ABSTRACTObjectivesTo elucidate risk factors for loss of hepatitis B virus (HBV) surface antibody (anti-HBs) in patients with rheumatic diseases and HBV surface-antigen negative/anti-HBs positive (HBsAg−/anti-HBs+) serostatus during biologic disease-modifying anti-rheumatic drug (DMARD) treatment.MethodsThis nested case-control study prospectively enrolled patients with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis/psoriasis, and juvenile idiopathic arthritis, who were treated with biologic DMARDs from January 2013 to September 2017. The analytic sample included patients with HBsAg−/anti-HBs+ serostatus. Anti-HBs titers were monitored, and cases defined as anti-HBs <10 mIU/mL during follow-up. Cases were matched one-to-all with controls with anti-HBs ≥10 mIU/mL on the same event date and equivalent durations of biologic DMARDs treatment. Between-group characteristics were compared and risk factors for anti-HBs loss elucidated by conditional logistic regression analyses.ResultsAmong 189 enrolled patients, 15 cases were matched with 211 controls. Risk factors associated with anti-HBs loss in multivariate analysis were low baseline anti-HBs titer (adjusted risk ratio = 0.96, 95% CI 0.93–0.99) and chronic kidney disease (adjusted risk ratio = 26.25, 95% CI 1.85–372.35). All cases had baseline anti-HBs titer <100 mIU/mL, and none developed HBV reactivation upon losing anti-HBs.ConclusionsIn addition to low baseline anti-HBs titer, chronic kidney disease is also an independent risk factors associated with loss of anti-HBs in patients with HBsAg−/anti-HBs+ serostatus who receive biologic DMARDs to treat rheumatic diseases.SignificanceGiven that loss of anti-HBs precedes HBV reactivation and that the use of biologic DMARDs is increasingly widespread nowadays, understanding those who are at risk of loss of anti-HBs is an important and practical clinical issue.InnovationIn addition to low baseline anti-HBs titer, chronic kidney disease is also an independent risk factors associated with loss of anti-HBs in patients with HBsAg−/anti-HBs+ serostatus who receive biologic DMARDs to treat rheumatic diseases.
Vector competence of Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus mosquitoes for Mayaro virus
Authors: Pereira Thiago Nunes , Carvalho Fabiano Duarte , De Mendonça Silvana Faria , Rocha Marcele Neves , Moreira Luciano Andrade 
Published: June 2019

AbstractNewly emerging or re-emerging arthropod-borne viruses (arboviruses) are important causes of human morbidity and mortality nearly worldwide. Arboviruses such as Dengue (DENV), Zika (ZIKV), Chikungunya (CHIKV) and West Nile virus (WNV) underwent an extensive geographic expansion in the tropical and sub-tropical regions of the world. In the Americas the main vectors, for DENV, ZIKV and CHIKV, are mosquito species adapted to urban environments namely Aedes aegypti and Aedes albopictus, whereas the main vector for WNV is the Culex quinquefasciatus. Given the widespread distribution in the Americas and high permissiveness to arbovirus infection, theses mosquito species might pose an important role in the epidemiology of other arboviruses normally associated to sylvatic vectors. Here, we test this hypothesis by determining the vector competence of Ae. aegypti, Ae. albopictus and Cx. quinquefasciatus to Mayaro (MAYV) virus, a sylvatic arbovirus transmitted mainly by Haemagogus janthinomys that have been causing an increasing number of outbreaks in South America namely in Brazil. Using field mosquitoes from Brazil, female mosquitoes were experimentally infected and their competence for dissemination and transmission for MAYV was evaluated. We found high dissemination rate for MAYV in Ae. aegypti (57.5%) and Ae. albopictus (61.6%), whereas very low rates were obtained for Cx. quinquefasciatus (2.5%). Concordantly, we observed that Ae. aegypti and Ae. albopictus have high transmission ability (69.5% and 71.1% respectively), conversely to Cx. quinquefasciatus that is not able to transmit the MAYV. Notably, we found that very low quantities of virus present in the saliva (undetectable by RT-qPCR) were sufficient and virulent enough to guarantee transmission. Although Ae. aegypti and Ae. albopictus mosquitoes are not the main vectors for MAYV, our studies suggest that these vectors may play a significant role in the transmission of this arbovirus, since both species showed high vector competence in laboratory conditions.Author summaryThe present study showed that Ae. aegypti and Ae. albopictus mosquitoes have high vector competence for MAYV, in laboratory. In contrast, Cx. quinquefasciatus mosquitoes were shown to be refractory to MAYV. Regarding the viral dilution and nanoinjection, higher detection sensitivity was observed after virus nanoinjection into naïve mosquitoes, indicating that only a few viral particles are required to infect mosquitoes, and these particles may not be detected by RT-qPCR before the nanoinjection procedure.
Development of a potent and protective germline-like antibody lineage against Zika virus in a convalescent human
Authors: Gao Fei , Lin Xiaohe , He Linling , Wang Ruoke , Wang Han , Shi Xuanling , Zhang Fuchun , Yin Chibiao , Zhang Linqi , Zhu Jiang , Yu Lei 
Published: June 2019

AbstractZika virus (ZIKV) specific neutralizing antibodies hold a great promise for antibody-based interventions and vaccine design against ZIKV infection. However, their development in infected patients remain unknown. Here, we report on the dynamic development of a potent and protective ZIKV-specific human antibody ZK2B10 initially isolated from a ZIKV convalescent individual using next-generation sequencing (NGS). The unbiased repertoire analysis showed dramatic changes in many families of heavy and light chain variable regions. However, lineage tracing of ZK2B10 revealed limited somatic hypermutation throughout the 12 months since the onset of symptom. In particular, NGS-derived germline-like somatic variants neutralized and protected mice from lethal challenge of ZIKV without detectable cross-reactivity with Dengue virus (DENV). Site-directed mutagenesis identified two residues within λ chain, N31 and S91 that are essential to the functional maturation. The dynamic features unveiled here will assist us to better understand the pathogenesis of ZIKV infection and inform rational design of vaccines.Author summaryRecently emerged ZIKV is associated with severe neurological complications such as Guillain–Barré syndrome in adults and congenital microcephaly in newborns. No ZIKV-specific therapeutics or vaccines are currently available. We and others have identified a number of neutralizing antibodies capable of protecting experimental animals from ZIKV infection. However, the development of these potent antibodies during ZIKV natural infection remains unknown. Here, we report on the longitudinal analysis of one such antibody ZK2B10 using next-generation sequencing (NGS), bioinformatics and functional analysis. We found that the ZK2B10 germline-like antibodies possess strong neutralizing activity in vitro and impressive protectivity against lethal ZIKV infection in vivo. These findings suggest that the potent and protective antibody response against ZIKV can be generated within relative short term with high germline identity which provide great hope and promise for successful vaccine development against ZIKV.
Unknown geometrical constraints estimation and trajectory planning for robotic door-opening task with visual teleoperation assists
Authors: Xing Hongjun , Xia Kerui , Ding Liang , Gao Haibo , Liu Guangjun , Deng Zongquan 
Published: June 2019

Purpose
The purpose of this paper is to enable autonomous door-opening with unknown geometrical constraints. Door-opening is a common action needed for mobile manipulators to perform rescue operation. However, it remains difficult for them to handle it in real rescue environments. The major difficulties of rescue manipulation involve contradiction between unknown geometrical constraints and limited sensors because of extreme physical constraints.

Design/methodology/approach
A method for estimating the unknown door geometrical parameters using coordinate transformation of the end-effector with visual teleoperation assists is proposed. A trajectory planning algorithm is developed using geometrical parameters from the proposed method.

Findings
The relevant experiments are also conducted using a manipulator suited to extreme physical constraints to open a real door with a locked latch and unknown geometrical parameters, which demonstrates the validity and efficiency of the proposed approach.

Originality/value
This is a novel method for estimating the unknown door geometrical parameters with coordinate transformation of the end-effector through visual teleoperation assists.
A novel active balance assistive control strategy based on virtual stiffness model of XCoM
Authors: Guo Wei , Qiu Shiyin , Zha Fusheng , Deng Jing , Wang Xin , Chen Fei 
Published: June 2019

PurposeThis paper aims to propose a novel balance-assistive control strategy for hip exoskeleton robot.Design/methodology/approachA hierarchical balance assistive controller based on the virtual stiffness model of extrapolated center of mass (XCoM) is proposed and tested by exoskeleton balance assistive control experiments.FindingsExperiment results show that the proposed controller can accelerate the swing foot chasing XCoM and enlarge the margin of stability.Originality/valueAs a proof of concept, this paper shows the potential for exoskeleton to actively assist human regain balance in sagittal plane when human suffers from a forward or backward disturbing force.
Efficiency evaluation of structural nonlinear analysis method based on the Woodbury formula
Authors: Li Gang , Jia Shuo , Li Hong-Nan 
Published: June 2019

Purpose
The purpose of this paper is to make a theoretical comprehensive efficiency evaluation of a nonlinear analysis method based on the Woodbury formula from the efficiency of the solution of linear equations in each incremental step and the selected iterative algorithms.

Design/methodology/approach
First, this study employs the time complexity theory to quantitatively compare the efficiency of the Woodbury formula and the LDLT factorization method which is a commonly used method to solve linear equations. Moreover, the performance of iterative algorithms also significantly effects the efficiency of the analysis. Thus, the three-point method with a convergence order of eight is employed to solve the equilibrium equations of the nonlinear analysis method based on the Woodbury formula, aiming to improve the iterative performance of the Newton–Raphson (N–R) method.

Findings
First, the result shows that the asymptotic time complexity of the Woodbury formula is much lower than that of the LDLT factorization method when the number of inelastic degrees of freedom (IDOFs) is much less than that of DOFs, indicating that the Woodbury formula is more efficient for local nonlinear problems. Moreover, the time complexity comparison of the N–R method and the three-point method indicates that the three-point method is more efficient than the N–R method for local nonlinear problems with large-scale structures or a larger ratio of IDOFs number to the DOFs number.

Originality/value
This study theoretically evaluates the efficiency of nonlinear analysis method based on the Woodbury formula, and quantitatively shows the application condition of the comparative methods. The comparison result provides a theoretical basis for the selection of algorithms for different nonlinear problems.
Managing “a little bit unsafe”: complexity, construction safety and situational self-organising
Authors: Sherratt Fred , Ivory Chris 
Published: June 2019

Purpose
The purpose of this paper is to unpack the shared understandings of safety held by workers on large UK construction sites using a complexity lens, and so provide empirical support for the inclusion of situational self-organising within construction site safety management systems (SMS).

Design/methodology/approach
A social constructionist epistemology supports the discourse analysis of talk (semi-structured interview and conversational), text (SMS and documentation) and visual (safety related signage) data collection from five large (+£20 m) UK construction sites.

Findings
Construction workers readily understand safety to be an emergent phenomenon with the complex system that is the construction site. Contemporary safety management approaches struggle with this complexity, yet there is the potential to mobilise situational self-organising on sites to improve safety in practice.

Research limitations/implications
Epistemological foundations mean no claim is made to generalisability as perceived by traditional positivistic parameters. The data are limited to large (+£20 m) UK construction sites; however, underlying construction management systems are common to the industry as a whole and can find fit with practitioner experiences and other empirical academic work from both the UK and other countries.

Practical implications
Situational self-organising of safety management within the construction workforce is proposed as a key contribution to a relevant, dynamic and effective SMS.

Originality/value
Data are analysed from a social constructionist perspective and considered through a complexity lens. This approach unpacks these data in an original way to seek synergy with existing adaptive safety approaches, specifically situational self-organising and make recommendations for practice.
Designing a framework of power procurement for a power distribution utility: a case study
Authors: Das Debadyuti , Kumar Virander , Bardhan Amit Kumar , Kumar Rahul 
Published: June 2019

Purpose
The study aims to find out an appropriate volume of power to be procured through long-term power purchase agreements (PPAs), the volume to be sourced from the power exchange through day-ahead and term-ahead options and also a suitable volume to be sold at different points of time within a day, which would finally lead to the optimum cost of power procurement.

Design/methodology/approach
The study has considered a Delhi-based power distribution utility and has collected all relevant data from its archival sources. A stochastic optimization model has been developed to capture the problem of power procurement faced by the distribution utility, which is modelled as a mixed integer linear programming problem. Sensitivity analyses were carried out on the important parameters including hourly demand of power, unit variable cost of power available through PPAs, maximum back-down percentage allowed under PPAs, etc., to investigate their impact on daily cost of power under PPAs, daily cost of power under day-ahead and term-ahead options, daily sales revenue and also the net total daily cost of power procurement.

Findings
The findings include the appropriate volume of power procured from different suppliers through PPAs and from the power exchange under day-ahead and term-ahead options and also the surplus volume of power sold under the day-ahead arrangement. It has also computed the total cost of power purchased under PPAs, the cost of power purchased from the power exchange under day-ahead and term-ahead options and also the revenue generated out of the sale of surplus power under the day-ahead arrangement. In addition, it has also presented the results of sensitivity analyses, which provide rich managerial insights.

Originality/value
The paper makes two significant contributions to the existing body of power procurement literature. First, the stochastic mixed-integer linear programming model helps decision makers in determining the right volume of power to be purchased from different sources. Second, based on the findings of the procurement model, a power procurement framework is developed considering the dimensions of uncertainty in power supply and the cost of power procurement. This power procurement framework would aid managers in making procurement decisions under different scenarios.
Overcoming the social problems faced by contemporary Acehnese through the social political role of Acehnese clerics (Muslim scholars)
Authors: Jamil Tengku Muhammad 
Published: June 2019

Purpose
The purpose of this study is to critically understand and find out the socio-political role of the Acehnese ulamas (Muslim scholars) in solving and coping with social issues faced by contemporary Acehnese society.

Design/methodology/approach
This study was conducted in the province of Nanggroe Aceh Darussalam, especially in the districts of Aceh Utara, Pidie, Aceh Besar, Aceh Selatan and Aceh Timur. The locations were chosen based on the consideration of the objective conditions that many ulamas were dwelling and could easily be found in these areas. Besides, the locations are historically believed as the origins of the Acehnese that are so diverse. In addition, a large number of social problems frequently arose within those regions. The subjects of this research study were a number of community determined by purposive sampling technique. The instruments used for the data collection in this research were observation, in-depth interview and library study; and interpretative understanding was also used to analyze the data.

Findings
The existence of the Acehnese ulamas represents the government’s recognition to word the traditional institutional in Aceh. However, some people think that institutions are used by the government to exploit ulama as the mediator between the government and the society. For the Acehnese ulamas, the institution could be used to consolidate their power for the benefit of the people.

Originality/value
The various theories discussed are considered the framework and guidance for this study, especially in terms of data collection and data analysis. The new theories and relevant references will also possibly be added to the following study.
UAE Islamic banking promotional strategies: an empirical review
Authors: Muhammad Abid Mahmood , Basha Mohamed Bilal , AlHafidh Gail 
Published: June 2019

PurposeThe purpose of this paper is to develop, measure and empirically validate the promotional techniques adopted by Islamic banks and the effect of these methods on consumer interest in Islamic banking products and services in the UAE (United Arab Emirates).Design/methodology/approachData were collected through 250 questionnaires distributed randomly to customers of five leading UAE Islamic banks and, following outlier analysis, the final sample size was reduced to 205, representing a sample of 82% of polled respondents. Multiple regression analysis was used on four key factor determinants that contributed towards the customers’ attitude in determining the most influential promotional strategies adopted by the Islamic banks.FindingsThe study found that the promotional strategies adopted by the UAE Islamic banking sector are having a significant impact on customer attitude towards Islamic banking products and services. The use of mass media has been partially successful, while the use of social media as a promotional tool is predicted to further enhance competitiveness for the UAE Islamic banking industry.Research limitations/implicationsThis paper is limited to five leading UAE Islamic banks and a specified set of promotional techniques nevertheless its findings have potential implications and can be extended and validated through studying the customers’ attitude towards promotion techniques used by Islamic banks in the GCC and MENA regions.Originality/valueThis paper adds value to the limited research on modern marketing and promotional strategies adopted by UAE-based Islamic banks and while regionally specific, it is valuable in its potential application to the Islamic banking sector in the entire GCC and MENA region.
Managing new and remanufactured products with remanufacturing degree under patent protection
Authors: Cao Xiaogang , Wang Xianjia , Wen Hui 
Published: June 2019

PurposeThis paper aims to propose a two-period model, including an original manufacturer, a retailer and a third-party remanufacturer, in which the products manufactured by the original manufacturer are patent-protected and the remanufacturing degree of remanufactured products influences the purchasing decisions of consumers.Design/methodology/approachThis paper analyzes the decisions of the original manufacturer, the retailer and the third-party remanufacturer of two periods, using Stackelberg game and obtains the equilibrium solutions of the three parties.FindingsThe study finds that consumers’ focus degree to the remanufacturing degree has a negative correlation with the equilibrium unit patent-licensing fee, the retail price of remanufactured products, the remanufacturing degree of remanufactured products and the wholesale price of new products in the first period, but has a positive correlation with the retail price of new products in the second period.Originality/value(1) Consumers’ focus degree to the remanufacturing degree has a negative correlation with the equilibrium unit patent-licensing fee, the retail price of remanufactured products, the remanufacturing degree of remanufactured products and the wholesale price of new products in the first period, but has a positive correlation with the retail price of new products in the second period. (2) The remanufacturing action efficiency of the third-party remanufacturer has a positive correlation with the equilibrium unit patent-licensing fee, the retail price of remanufactured products, the remanufacturing degree of remanufactured products and the wholesale and retail prices of new products in the second period.
GEP-based predictive modeling of breathing resistances of wearing respirators on human body via sEMG and RSP sensors
Authors: Chen Yumiao , Yang Zhongliang 
Published: June 2019

PurposeBreathing resistance is the main factor that influences the wearing comfort of respirators. This paper aims to demonstrate the feasibility of using the gene expression programming (GEP) for the purpose of predicting subjective perceptions of breathing resistances of wearing respirators via surface electromyography (sEMG) and respiratory signals (RSP) sensors.Design/methodology/approachThe authors developed a physiological signal monitoring system with a specific garment. The inputs included seven physical measures extracted from (RSP) and (sEMG) signals. The output was the subjective index of breathing resistances of wearing respirators derived from the category partitioning-100 scale with proven levels of reliability and validity. The prediction model was developed and validated using data collected from 30 subjects and 24 test combinations (12 respirator conditions × 2 motion conditions). The subjects evaluated 24 conditions of breathing resistances in repeated measures fashion.FindingsThe results show that the GEP model can provide good prediction performance (R2= 0.71, RMSE = 0.11). This study demonstrates that subjective perceptions of breathing resistance of wearing respirators on the human body can be predicted using the GEP via sEMG and RSP in real-time, at little cost, non-invasively and automatically.Originality/valueThis is the first paper suggesting that subjective perceptions of subjective breathing resistances can be predicted from sEMG and RSP sensors using a GEP model, which will remain helpful to the scientific community to start further human-centered research work and product development using wearable biosensors and evolutionary algorithms.