bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gestational hypertension and pre‐eclampsia and risk of spontaneous premature rupture of membranes: A population‐based cohort study
Authors: Liu Lijun , Wang Linlin , Yang Wenlei , Ni Wenli , Jin Lei , Liu Jianmeng , Ren Aiguo 
Published: August 2019

AbstractObjectiveTo examine whether gestational hypertension and pre‐eclampsia are associated with spontaneous premature rupture of membranes (PROM).MethodsA retrospective, population‐based cohort study was conducted in Hebei, Zhejiang, and Jiangsu provinces in China from 1993 to 1995. After excluding women with missing data of exposure and outcome, history of chronic hypertension, multiple births, and babies with major birth defects and ambiguous sex, this study comprised 199 231 singleton live births. Logistic regression was used to evaluate the association, adjusting for potential confounders.ResultsThe incidence of PROM was 17.7% and 8.9% in women with gestational hypertension and pre‐eclampsia, respectively, and 5.9% for the normotensive group. Compared with normotension, gestational hypertension was associated with an increase in the odds of PROM of 4.21 times (95% confidence interval [CI] 3.77–4.70), while pre‐eclampsia had an increase of 2.27 times (95% CI 1.78–2.88). Additionally, women with hypertensive disorders of pregnancy had higher risks for term PROM (adjusted risk ratio [RR] 3.83, 95% CI 3.43–4.27) than preterm PROM (adjusted RR 3.10, 95% CI 2.18–4.41). Consistent results of the association were also observed in the sensitivity analyses.ConclusionGestational hypertension and pre‐eclampsia were associated with an increased risk for PROM. Increased odds were observed for term PROM compared with preterm PROM.
Anaemia is associated with an increased risk for caesarean delivery
Authors: Adam Ishag , Kheiri Sumeya , Sharif Manal E. , Ahmed Abdel B.A. , Rayis Duria A. 
Published: August 2019

AbstractObjectiveTo investigate the association between anemia and cesarean delivery.MethodsA case‐control study was conducted in Saad Abu‐Alela Hospital in Khartoum, Sudan from March 1 to November 30, 2107. The cases were women who had cesarean delivery; women who delivered vaginally were the controls. Obstetrics history was gathered using a questionnaire.ResultsThere was no significant difference in age, parity, residence, job, education, and newborn gender between women who delivered by cesarean (n=130) and women who delivered vaginally (n=260). While mean (SD) of the body mass index (29.3 (5.4) kg/m2 vs 26.3 (5.6) kg/m2, P<0.001) was significantly higher, hemoglobin level (103.0 (8.0) g/L vs 107.0 (8.0) g/L, P=0.001) was significantly lower in women who delivered by cesarean compared with women who delivered vaginally. In logistic regression analyses, age, gravidity, occupation, education, history of miscarriage, and newborn gender were not associated with cesarean delivery; overweight (adjusted odds ratio [AOR] 2.30, 95% confidence interval [CI] 1.24–4.26), obesity (AOR 7.17, 95% CI 3.64–14.13) and anemia (AOR 2.45, 95% CI 1.47–4. 11) were associated with cesarean delivery.ConclusionThe significant association between anemia and cesarean delivery has important implications for the prevention and treatment of anemia among these women.
Hsa_circ_101882 promotes migration and invasion of gastric cancer cells by regulating EMT
Authors: Yin Gui‐Hua , Gao Fu‐Cun , Tian Juan , Zhang Wen‐Bo 
Published: August 2019

AbstractBackgroundAt present, gastric cancer (GC) is a serious threat to human life and health. Non‐coding circular RNAs (circRNAs) have been found abnormal expression in multiple tumors. However, circRNAs remain largely unknown in tumor progression. In the present study, we mainly examined the expression, function, and molecular mechanisms of a new circRNAs (hsa_circ_101882) in GC.Materials and methodsThe expression of hsa_circ_101882 in GC tissue, corresponding adjacent normal tissues, and GC cell lines was examined by RT‐PCR. The function of hsa_circ_101882 in GC was evaluated by MTT assay, cell migration, and invasion assay, colony formation assay, and flow cytometric assay. The effect of hsa_circ_101882 on epithelial‐to‐mesenchymal transition (EMT)‐related gene expression was detected by RT‐PCR and Western blot.ResultsHsa_circ_101882 expression levels were significantly increased in GC tissue and GC cell lines. Functionally, low expression of hsa_circ_101882 revealed anti‐tumor effects via inhibiting cell growth, migration, and invasion and promoting cell apoptosis. Mechanically, the dysregulated expression of hsa_circ_101882 affects EMT signaling pathway, which was examined by detecting E‐cadherin, N‐cadherin, vimentin, and Snail expression levels.ConclusionsTherefore, our research reveals that hsa_circ_101882 is considered a metastasis promoter by activating EMT and may serve as a critical oncogene and potential new biomarker in GC.
An investigation of microRNA‐103 and microRNA‐107 as potential blood‐based biomarkers for disease risk and progression of Alzheimer's disease
Authors: Wang Jie , Chen Chunyan , Zhang Yun 
Published: August 2019

AbstractBackgroundThis study aimed to assess the correlation of circulating microRNA‐103 (miR‐103) and microRNA‐107 (miR‐107) with disease risk and cognitive impairment of Alzheimer's disease (AD).MethodsPlasma samples from 120 AD patients, 120 Parkinson's disease (PD) patients (served as disease control), and 120 healthy controls were collected for miR‐103 and miR‐107 detections using real‐time quantitative polymerase chain reaction. Mini‐Mental State Examination (MMSE) score was documented and was used to accordingly assess the dementia severity.ResultsmiR‐103 expression was decreased in AD patients compared with PD patients and healthy controls, and receiver operating characteristic (ROC) curve analyses illustrated that it was able to differentiate AD patients from PD patients and healthy controls. Additionally, miR‐103 positively correlated with MMSE score and negatively correlated with dementia severity in AD patients. miR‐107 expression was lower in AD patients compared with healthy controls but similar between AD patients and PD patients, and ROC curve analyses revealed that it was able to differentiate AD patients from healthy controls but not AD patients from PD patients. miR‐107 was positively correlated with MMSE score and negatively correlated with dementia severity in AD patients, while the correlation coefficient of miR‐107 with MMSE score was lower than that of miR‐103 with MMSE score. Besides, miR‐103 was positively correlated with miR‐107 in AD patients, PD patients, and healthy controls.ConclusionmiR‐103 may be a better choice than miR‐107 to serve as a potential biomarker for disease risk and disease progression of AD.
Mental health change in the transition to permanent supportive housing: The role of housing and social networks
Authors: Harris Taylor , Rhoades Harmony , Duan Lei , Wenzel Suzanne L. 
Published: August 2019

AbstractAims: Permanent Supportive Housing (PSH) may improve homeless adults’ mental health via housing stabilization and/or improved relational factors, however, the role of housing and social networks on PSH residents' mental health change is minimally understood.Methods: Interviews were conducted with a baseline sample of adults experiencing homelessness (
N = 421), across their initial year in PSH (3‐months, 6‐months, and 12‐months). Generalized linear mixed models assessed changes in positive past‐month psychiatric disability screenings (Modified‐Colorado Symptom Index [MCSI]) and probable posttraumatic stress disorder (PC‐PTSD) in controlled models, and between and within‐subject effects of time‐varying social network correlates on mental health changes.Results: Compared with baseline, positive MCSI screens continuously decreased over time (56%, 54%, and 50%) while PC‐PTSD screens declined initially (40%) with marginal decreases at remaining follow‐ups (39% and 38%). These differences remained significant in controlled models. Gaining a romantic partner was associated with a longitudinal increase in a positive MCSI screening. Between subjects, emotional health counselors and conflicting network members were associated with an increased likelihood in positive screenings, while doctors and case managers were protective.Conclusion: Housing may facilitate positive changes in PSH residents' mental health, yet positive screenings remain high. Social network interventions that increase residents’ positive interpersonal exchanges and prosocial relationships are warranted.
Structural and social determinants of inequities in violence risk: A review of indicators
Authors: Armstead Theresa L. , Wilkins Natalie , Nation Maury 
Published: August 2019

AbstractThere is disproportionate risk for violence conditioned on inequities due to race, socioeconomic status, gender, and where people live. Consequently, some communities are more vulnerable to violence and its repercussions than other communities. This study aims to share indicators that might be useful for violence prevention researchers interested in measuring structural or social determinants that position communities for differential risk of experiencing violence. An existing database of indicators identified in a previous review was reassessed for measures of factors that shape community structures and conditions, which place people at risk for violence. Indicators of 86 community constructs are reported. These indicators may help to advance the field by offering innovative metrics that can be used to investigate further the structural and social determinants that serve as root causes of inequities in violence risk.
A novel mutation (c.1010G>T; p.R337L) in TP63 as a cause of split‐hand/foot malformation with hypodontia
Authors: Jin Jie‐Yuan , Zeng Lei , Li Ke , He Ji‐Qiang , Pang Xiaoyang , Huang Hao , Xiang Rong , Tang Ju‐Yu 
Published: August 2019

AbstractBackgroundTumor protein p63 (TP63)‐related disorders can be divided into at least six categories, including ectrodactyly‐ectodermal dysplasia‐cleft lip/palate syndrome 3 (EEC syndrome 3), ankyloblepharon‐ectodermal defects‐cleft lip/palate syndrome (AEC syndrome), acro‐dermo‐ungual‐lacrimal‐tooth syndrome (ADULT syndrome), limb‐mammary syndrome (LMS), Rapp–Hodgkin syndrome (RHS) and split‐hand/foot malformation 4 (SHFM4), and are all a result of heterozygous mutations of TP63. The phenotypes of TP63‐related disorders broadly involve ectodermal dysplasias, acromelic malformation and orofacial cleft. SHFM and hypodontia are prominent clinical manifestations of TP63‐related disorders.MethodsThe present study investigated a family with SHFM and hypodontia; determined the sequences of DLX5, WNT8B, WNT10B, BHLHA9, CDH3, DYNC1I1 and FGFR1; and performed single nucleotide polymorphism‐array analysis. We detected the mutation by multiple sequence alignments and a bioinformatic prediction.ResultsWe identified a novel missense mutation of TP63 (c.1010G>T; R337L) in the family without mutations of DLX5, WNT8B, WNT10B, BHLHA9, CDH3, DYNC1I1, FGFR1 and copy number variants causing SHFM.ConclusionsA mutation of TP63 (c.1010G>T; R337L) leads to SHFM with hypodontia. The identification of this mutation expands the spectrum of known TP63 mutations and also may contribute to novel approaches for the genetic diagnosis and counseling of families with TP63‐related disorders.
Nonimmune hydrops fetalis and congenital disorders of glycosylation: A systematic literature review
Authors: Makhamreh Mona M. , Cottingham Naiga , Ferreira Carlos R. , Berger Seth , Al‐Kouatly Huda B. 
Published: August 2019

AbstractNumerous etiologies may lead to nonimmune hydrops fetalis (NIHF) including congenital disorders of glycosylation (CDG). Recognition of CDG in NIHF is challenging. This study reviews prenatal and neonatal characteristics of CDG presenting with NIHF. A systematic literature search was performed. Thirteen articles met the inclusion criteria. Twenty‐one cases with NIHF associated with a CDG were reported. There were 17 live births, three pregnancy terminations, and one fetal demise. Timing of CDG diagnosis was reported mostly postnatally (90%; 10/11). Postnatal genetic testing was reported in 18 patients; three patients were diagnosed by isoelectric focusing of serum transferrin that showed a type 1 pattern. The genes reported for CDG with NIHF for 15 distinct families include: PMM2 in 47% (7/15), ALG9 in 20% (3/15), ALG8 in 13% (2/15), ALG1 in 7% (1/15), MGAT2 in 7% (1/15), and COG6 7% (1/15). In our review, 81% (17/21) reported facial dysmorphism, 52% (11/21) reported CNS abnormalities, most commonly cerebellar atrophy (64%; 7/11), and 38% (8/21) reported cardiovascular abnormalities, most commonly hypertrophic cardiomyopathy (63%; 5/8). Among live births, 71% (12/17) infants died at a median age of 34 days (range 1‐185). Thrombocytopenia was reported in 53% (9/17) patients. Of those who survived past the neonatal period, 80% (4/5) had significant reported developmental delays. CDG should be on the differential diagnosis of NIHF in the presence of cerebellar atrophy, hypertrophic cardiomyopathy, or thrombocytopenia. Our review highlights the poor prognosis in infants with NIHF due to CDG and demonstrates the importance of identifying these disorders prenatally to guide providers in their counseling with families regarding pregnancy management.SynopsisPoor prognosis in fetuses and infants with nonimmune hydrops fetalis due to congenital disorders of glycosylation highlights the importance of prenatal diagnosis of this disorder.
Investigations into ventral prefrontal cortex using mediation models
Authors: Hu Kesong 
Published: August 2019

AbstractThe ventral prefrontal cortex (vPFC) is a major focus of investigation in neuroscience, particularly in the studies of emotion and emotion‐cognition integration. A crucial question concerning the regulatory function of vPFC is how it is recruited, especially how the function maps onto the structure and determines appropriate behavior. In social exclusion studies, mediation model analyses suggest that vPFC regulates distress by disrupting anterior cingulate cortex (ACC) activities, whereas I recently report (Hu, 2018; Neuropsychologia) that ventral medial prefrontal cortex appears to defend the organism from acute stress by activating ACC. In this review, I synthesize and highlight functional imaging research with mediation analysis that over the past decades has begun to offer new insights into the brain mechanisms underlying vPFC. Toward this end, the first section of the paper outlines a model of the processes and neural systems involved in the interaction of emotion and cognition. The second and third sections survey recent research on emotional regulation with negative and positive pathways, respectively, emanating from vPFC. The fourth section summarizes the current dynamic network findings. Functional mediation analysis helps to identify signals within vPFC and others that are common and/or specific to particular information processing. Finally, I provide a personal perspective of the adoption of mediation model analysis in the investigations into vPFC.
Enhanced mitochondrial inhibition by 3,4‐dihydroxyphenyl‐acetaldehyde (DOPAL)‐oligomerized α‐synuclein
Authors: Sarafian Theodore A. , Yacoub Amneh , Kunz Anastasia , Aranki Burkan , Serobyan Grigor , Cohn Whitaker , Whitelegge Julian P. , Watson Joseph B. 
Published: August 2019

AbstractOligomeric forms of α‐synuclein are believed to cause mitochondrial injury, which may contribute to neurotoxicity in Parkinson's disease (PD). Here oligomers of α‐synuclein were prepared using the dopamine metabolite, DOPAL (3,4‐dihydroxyphenyl‐acetaldehyde), in the presence of guanidinium hydrochloride. Electron microscopy, mass spectrometry, and Western blotting studies revealed enhanced and stable oligomerization with DOPAL compared with dopamine or CuCl2/H2O2. Using isolated mouse brain mitochondria, DOPAL‐oligomerized α‐synuclein (DOS) significantly inhibited oxygen consumption rates compared with untreated, control‐fibrillated, and dopamine‐fibrillated synuclein, or with monomeric α‐synuclein. Inhibition was greater in the presence of malate plus pyruvate than with succinate, suggesting the involvement of mitochondrial complex I. Mitochondrial membrane potential studies using fluorescent probes, JC‐1, and Safranin O also detected enhanced inhibition by DOS compared with the other aggregated forms of α‐synuclein. Testing a small customized chemical library, four compounds were identified that rescued membrane potential from DOS injury. While diverse in chemical structure and mechanism, each compound has been reported to interact with mitochondrial complex I. Western blotting studies revealed that none of the four compounds disrupted the oligomeric banding pattern of DOS, suggesting their protection involved direct mitochondrial interaction. The remaining set of chemicals also did not disrupt oligomeric banding, attesting to the high structural stability of this α‐synuclein proteoform. DOPAL and α‐synuclein are both found in dopaminergic neurons, where their levels are elevated in PD and in animal models exposed to chemical toxicants, including agricultural pesticides. The current study provides further evidence of α‐synuclein‐induced mitochondrial injury and a likely role in PD neuropathology.
How minimally interrupted direct oral anticoagulants affect intraprocedural anticoagulation during atrial fibrillation ablation? Insights from a Japanese single‐center retrospective study
Authors: Mizobuchi Masahiro , Funatsu Atsushi , Kobayashi Tomoko , Nakamura Shigeru 
Published: August 2019

AbstractBackgroundData are still lacking regarding the effects of minimally interrupted direct oral anticoagulants (MID) on the intensity of intraprocedural anticoagulation of atrial fibrillation (AF) ablation.MethodsA total of consecutive 269 patients who undergone AF ablation were eligible for the study. All oral anticoagulants (OACs) were discontinued just one dose before the procedure except warfarin. We assessed the total required dose of UFH and time‐to‐target ACT > 300 seconds (TTA) for each of direct oral anticoagulant (DOAC) groups compared with the uninterrupted warfarin group.ResultsDOACs were used in 86% of the patients in the present study (dabigatran group (DG)‐17%, rivaroxaban group (RG)‐30%, apixaban group (AG)‐29%, and edoxaban group (EG)‐10%). DG and EG used comparable dose of total UFH to WG (WG vs DG; 206 ± 53 U/kg vs 231 ± 63 U/kg; P = .664, vs EG; 239 ± 67 U/kg; P = .335), while RG and AG required higher total UFH (WG vs RG; 206 ± 53 U/kg vs 270 ± 63 U/kg; P < .001, vs AG; 263 ± 62 U/kg; P < .001). TTA was significantly longer in RG (RG:73 ± 28 minutes vs WG:51 ± 25 minutes; P = .001), AG (AG:64 ± 26 minutes vs WG:51 ± 25 minutes; P = .02), and EG (EG:67 ± 34 minutes vs WG:51 ± 25 minutes; P = .02) than WG, whereas DG was comparable to WG (DG:51 ± 29 minutes vs WG:51 ± 25 minutes; P = NS). Especially, only RG demonstrated significantly slower increase in ACT than WG (P = .013). In the multivariate analysis, warfarin or dabigatran use, age > 75 years, and body weight < 60 kg are clinical predictors for achieving TTA within 60 minutes (TTA‐60).ConclusionMID‐dabigatran was comparable to uninterrupted warfarin, whereas MID‐factor Xa inhibitors were not. MID is a feasible protocol; however, we should be aware of its effect on the intraprocedural anticoagulation and differences among DOACs in the responsiveness to heparin.
Study design and protocol for evaluating the long‐term prognosis of patients receiving his bundle pacing: A multicenter observational study
Authors: Yanagisawa Satoshi , Inden Yasuya , Kato Hiroyuki , Suzuki Hirohiko , Fujita Masaya , Ishikawa Shinji , Kanzaki Yasunori , Kamikubo Yosuke , Murase Yosuke , Murohara Toyoaki , Shibata Rei 
Published: August 2019

AbstractBackgroundHis bundle pacing (HBP) is a recently developed pacing technique that can achieve an ideal physiological pattern of ventricular activation via stimulation of the native His‐Purkinje system. Despite the widespread introduction of HBP in clinical practice, its appropriate indications are yet to be determined clearly. Moreover, the efficacy and safety of HBP and long‐term prognosis of patients undergoing such are unknown.MethodsWe conducted a multicenter observational prospective study in patients undergoing HBP in Japan. Patients with atrioventricular block or conduction delay and estimated ventricular pacing of ≥ 40% scheduled for HBP implantation are included. All patients are followed up until 3 years after the implantation. The primary endpoints are all‐cause death, heart failure‐related hospitalization, and upgrade to cardiac resynchronization therapy. The secondary endpoint is changes in cardiac function based on echocardiographic findings and laboratory data after the implantation.ResultsThe results are currently under investigation.ConclusionsThis multicenter observational study evaluates the long‐term prognosis and changes in cardiac function of patients undergoing HBP implantation in a clinical setting. Considering the large number of patients included, the cumulative results would be helpful in establishing evidence on HBP application in this area and consequently allow accurate management and treatment of patients undergoing HBP.
Evaluating antibacterial and anticancer activity of crude extracts of bacterial endophytes from Crinum macowanii Baker bulbs
Authors: Sebola Tendani E. , Uche‐Okereafor Nkemdinma C. , Tapfuma Kudzanai I. , Mekuto Lukhanyo , Green Ezekiel , Mavumengwana Vuyo 
Published: August 2019

AbstractThe results from this study revealed that crude extracts isolated from bacterial endophytes obtained from Crinum macowanii bulbs showed activity against both Gram‐positive and Gram‐negative pathogenic bacteria, while Acinetobacter guillouiae crude extracts displayed anticancer activity. This study aimed to isolate and characterize bacterial endophytes and their crude extracts from C. macowanii bulbs. Endophytes were isolated using validated surface sterilization techniques, followed by phenotypic and genotypic profiles of the isolates. Crude extracts were extracted from the endophytes using ethyl acetate, while methanol:dichloromethane (1:1) was used to obtain crude extracts from the bulbs. Antibacterial activity of crude extract from each endophyte was investigated against selected pathogenic strains using the broth microdilution method, and anticancer activity against U87MG glioblastoma and A549 lung carcinoma cells was determined by the MTS (3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxy‐phenyl)‐2‐(4‐sulfophenyl)‐2H‐tetrazolium) assay. Acinetobacter guillouiae, Pseudomonas moraviensis, Pseudomonas sp., Rahnella aquatilis, Bacillus cereus, Novosphingobium sp., Raoultella ornithinolytica, and Burkholderia tropica were successfully isolated. The crude extracts from the majority of endophytes showed antibacterial activity, ranging from 0.125 to >16.00 mg/ml against Gram‐negative and Gram‐positive pathogenic bacteria. Acinetobacter guillouiae extracts showed a high bioactive potential against U87MG glioblastoma cell lines by reducing their growth by 50% at concentrations of 12.5, 6.25, and 3.13 µg/ml. Crude extracts isolated from C. macowanii bulbs showed potential for possible drug lead against common pathogenic bacteria.