bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pneumonectomy for non-tumoral diseases: etiologies and follow-up in 38 cases
Authors: Harmouchi Hicham , Sani Rabiou , Belliraj Layla , Ammor Fatimazahra , Issoufou Ibrahim , Lakranbi Marouane , Ouadnouni Yassine , Smahi Mohammed 
Published: February 2019

Introduction Pneumonectomy is a surgical procedure associated with high rates of morbidity and mortality. Chronic inflammatory pathologies increase these rates, depending on the degree of pleural symphysis and the underlying pulmonary pathology. The occurrence of a bronchopleural fistula after pneumonectomy remains of great concern to the thoracic surgeon, because it leads to empyema in the pneumonectomy cavity, which requires protracted and difficult management. Methods A retrospective single-center study was carried out on 38 patients who underwent pneumonectomy for non-tumoral pathologies between 2010 and 2017. Of the 38 patients, 22 (57.8%) men and 16 (42.2%) women, the average age was 40.3 years, and 30 (79%) patients were treated for tuberculosis. Results The symptoms were predominantly hemoptysis with bronchorrhea in 22 (57.9%) cases. Chest computed tomography showed right-sided involvement in 15 (39.5%) patients, with destroyed lung in 31 (81.5%). Early postoperative complications included bleeding in 11 (28.9%) patients, postpneumonectomy empyema in 4 (10.5%), and death in 2 (5.2%). The average duration of follow-up was 2 years, without any recurrence. Conclusion The endemicity of tuberculosis in our context, and the absence of screening for lung cancer, explain the frequency of pneumonectomy for chronic inflammatory diseases, and the rate of complications after this surgical procedure.
Pharmaco-epidemiology of antidepressant exposure in a UK cohort record-linkage study
Authors: Hafferty Jonathan D , Wigmore Eleanor M , Howard David M , Adams Mark J , Clarke Toni-Kim , Campbell Archie I , MacIntyre Donald J , Nicodemus Kristin K , Lawrie Stephen M , Porteous David J , McIntosh Andrew M 
Published: February 2019

Objectives: Antidepressants are the most commonly prescribed psychiatric medication but concern has been raised about significant increases in their usage in high income countries. We aimed to quantify antidepressant prevalence, incidence, adherence and predictors of use in the adult population. Methods: The study record-linked administrative prescribing and morbidity data to the Generation Scotland cohort ( N = 11,052), between 2009 and 2016. Prevalence and incidence of any antidepressant use was determined. Antidepressant adherence was measured using Proportion of Days Covered and Medication Possession Ratio. Time-to-event analysis for incident antidepressant use within 5 years of Generation Scotland: Scottish Family Health Study (GS:SFHS) recruitment was performed to reveal patient-level predictors of use. Results: Almost one-third (28.0%, 95%CI 26.9–29.1) of the adults in our sample were prescribed at least one antidepressant in the 5-year period 2012–2016. There was a 36.2% increase in annual prevalence between 2010 and 2016. Incidence was 2.4(2.1–2.7)% per year. The majority of antidepressant episodes (57.6%) were greater than 9 months duration and adherence was generally high (69.0% with Proportion of Days Covered >80%). Predictors of new antidepressant use included history of affective disorder, being female, physical comorbidities, higher neuroticism scores, and lower cognitive function scores. Conclusions: Antidepressant prevalence is greater than previously reported but incidence remains relatively stable. We found the majority of antidepressant episodes to be of relatively long duration with good estimated adherence. Our study supports the hypothesis that increased long-term use among existing (and returning) users, along with wider ranges of indications for antidepressants, has significantly increased the prevalence of these medications.
Reduced artifacts and improved diagnostic value of 640-slice computed tomography in patients with cardiac pacemakers
Authors: Cao Guoquan , Chen Weijian , Pan Kehua , Sun Houchang , Wang Zhen 
Published: February 2019

Objective The aim of this study was to compare the feasibility of 640-slice with 64-slice computed tomography (CT) coronary angiography for diagnosing coronary lesions in patients with pacemakers. Methods Forty-five and 50 patients with pacemakers and with suspected or known coronary artery disease underwent 64-slice (64 group) and 640-slice (640 group) CT scans, respectively. All segments of the vessels were evaluated according to the 15-segment model recommended by the American Heart Association. Results The incidence of moderate or severe artifacts was significantly lower (7.27% vs. 32.17%) and the diagnosable rate for coronary lesions was higher (98.91% vs. 94.19%) in the 640 compared with the 64 group. In the 64 group, the incidence of artifacts in patients with a heart rate >65 bpm (20.98%) was higher than in those with a heart rate <65 bpm (15.67%), although the difference was not significant, while the incidence of artifacts was significantly higher in patients with heart arrhythmia (21.40%) compared with in those with normal heart rhythm (15.09%). Conclusions Among patients with pacemakers and a higher heart rate or heart arrhythmia, 640-slice CT may be more effective than 64-slice CT for diagnosing coronary lesions, by reducing moderate and severe artifacts.
Estimating Resting Energy Expenditure by Different Methods as Compared With Indirect Calorimetry for Patients With Pulmonary Hypertension
Authors: Zanella Priscila Berti , Ávila Camila Coutinho , de Souza Carolina Guerini 
Published: February 2019

AbstractBackground: For patients with pulmonary hypertension, nutrition status is an independent predictor of morbidity and mortality, and energy expenditure can be strongly influenced by lung disease. Indirect calorimetry (IC) is the gold standard for measuring resting energy expenditure (REE), this study aimed to compare the results of REE estimated by different methods with those obtained by IC for patients with pulmonary hypertension. Methods: In this cross‐sectional study (n = 34), REE was estimated by bioelectrical impedance analysis and the predictive equations of Harris‐Benedict, Food and Agriculture Organization / World Health Organization, Institute of Medicine, Cunningham, Katch‐McArdle, and Mifflin‐St Jeor. Results: Mean patient age was 47.0 ± 14.5 years, and 76.5% were women. REE obtained with IC was strongly correlated with all other estimation methods but showed higher mean values: IC 1750.8 ± 434.3 kcal vs bioelectrical impedance analysis, 1549.0 ± 417.8 kcal; Harris‐Benedict, 1493.1 ± 337.0 kcal; FAO/WHO, 1536.1 ± 345.0 kcal; Institute of Medicine, 1457.1 ± 293.2 kcal; Cunningham, 1597.3 ± 292.3 kcal; Katch‐McArdle, 1447.7 ± 287.0 kcal; and Mifflin‐St Jeor, 1388.7 ± 303.9 kcal. The analysis of agreement showed a clinically significant bias of approximately −255 kcal in all estimation methods when compared with IC. Conclusion: Although there was a strong correlation between REE estimation methods and IC, there was no agreement between them. All estimation methods underestimated energy needs by about 255 kcal for patients with pulmonary hypertension, and the Cunningham equation had the smallest difference in relation to IC.
Patient-reported outcomes of adults with congenital heart disease from eight European countries: scrutinising the association with healthcare system performance
Authors: Van Bulck Liesbet , Luyckx Koen , Goossens Eva , Apers Silke , Kovacs Adrienne H , Thomet Corina , Budts Werner , Sluman Maayke A , Eriksen Katrine , Dellborg Mikael , Berghammer Malin , Johansson Bengt , Caruana Maryanne , Soufi Alexandra , Callus Edward , Moons Philip 
Published: February 2019

Background: Inter-country variation in patient-reported outcomes of adults with congenital heart disease has been observed. Country-specific characteristics may play a role. A previous study found an association between healthcare system performance and patient-reported outcomes. However, it remains unknown which specific components of the countries’ healthcare system performance are of importance for patient-reported outcomes. Aims: The aim of this study was to investigate the relationship between components of healthcare system performance and patient-reported outcomes in a large sample of adults with congenital heart disease. Methods: A total of 1591 adults with congenital heart disease (median age 34 years; 51% men; 32% simple, 48% moderate and 20% complex defects) from eight European countries were included in this cross-sectional study. The following patient-reported outcomes were measured: perceived physical and mental health, psychological distress, health behaviours and quality of life. The Euro Health Consumer Index 2015 and the Euro Heart Index 2016 were used as measures of healthcare system performance. General linear mixed models were conducted, adjusting for patient-specific variables and unmeasured country differences. Results: Health risk behaviours were associated with the Euro Health Consumer Index subdomains about patient rights and information, health outcomes and financing and access to pharmaceuticals. Perceived physical health was associated with the Euro Health Consumer Index subdomain about prevention of chronic diseases. Subscales of the Euro Heart Index were not associated with patient-reported outcomes. Conclusion: Several features of healthcare system performance are associated with perceived physical health and health risk behaviour in adults with congenital heart disease. Before recommendations for policy-makers and clinicians can be conducted, future research ought to investigate the impact of the healthcare system performance on outcomes further.
Minimally Invasive Versus Open Transforaminal Lumbar Interbody Fusion Surgery: An Analysis of Opioids, Nonopioid Analgesics, and Perioperative Characteristics
Authors: Hockley Aaron , Ge David , Vasquez-Montes Dennis , Moawad Mohamed A. , Passias Peter Gust , Errico Thomas J. , Buckland Aaron J. , Protopsaltis Themistocles S. , Fischer Charla R. 
Published: February 2019

Study Design: Retrospective study of consecutive patients at a single institution.Objective: Examine the effect of minimally invasive surgery (MIS) versus open transforaminal lumbar interbody fusion (TLIF) surgery on long-term postoperative narcotic consumption. Objective: Examine the effect of minimally invasive versus open TLIF on short-term postoperative narcotic consumption. Methods: Differences between MIS and open TLIF, including inpatient opioid and nonopioid analgesic use, discharge opioid use, and postdischarge duration of narcotic usage were compared using appropriate statistical methods. Results: A total of 172 patients (109 open; 63 MIS) underwent primary TLIF. There was no difference in baseline characteristics. The MIS TLIF cohort had a significantly shorter operative time (223 vs 251 min, P = .006) and length of stay (2.7 vs 3.7 days, P < .001) as well as less estimated blood loss (184 vs 648 mL, P < .001). MIS TLIF had significantly less total inpatient opioid usage (167 vs 255 morphine milligram equivalent [MME], P = .006) and inpatient oxycodone usage (71 vs 105 mg, P = .049). Open TLIF cases required more ongoing opiate usage at 3-month follow-up (36% open vs 21% MIS, P = .041). A subanalysis found that patients who underwent an open TLIF with a history of preoperative opioid use are significantly more likely to remain on opioids at 6-week follow-up (87% vs 65%, P = .027), 3-month follow-up (63% vs 31%, P = .008), and 6-month follow-up (50% vs 21%, P = .018) compared with MIS TLIF. Conclusion: Patients undergoing MIS TLIF required less inpatient opioids and had a decreased incidence of opioid dependence at 3-month follow-up. Patients with preoperative opioid use undergoing MIS TLIF are less likely to require long-term opioids.
Cervical Lymph Node Schwannoma—An Unexpected Diagnosis
Authors: Silvestre Catarina Falcão , Tavares Joana Almeida , López-Presa Dolores , dos Santos Vanessa Rebelo , Rocha José , João Bugalho Maria 
Published: February 2019

Introduction: Schwannomas—Schwann cells–originating tumors—may develop in many locations. However, primary schwannomas arising within lymph nodes are extremely rare, with only a few cases described to this date in the English literature. For the intranodal location, most of the cases are described in the abdominal cavity. In these cases, clinicians may consider and check for familial disorders, such as neurofibromatosis type 2 (NF2) and schwannomatosis also called neurofibromatosis type 3. Schwannomas are benign neoplasms. Histologically, differential diagnosis for spindle-cell lesions in lymph nodes is important and must be done carefully, mainly because they may be attributable to metastatic disease. We report a case of a primary schwannoma arising in a cervical lymph node. Background: Primary schwannomas arising within lymph nodes are extremely rare, with only a few cases reported. Since they are benign neoplasms, the differential diagnosis with other intranodal spindle cell lesions, mostly malignant, is important. Methods: An asymptomatic 69-year-old woman, previously submitted to left hemithyroidectomy for a benign folicular nodule, underwent thyroidectomy totalization following the identification of a large thyroid nodule in routine evaluation. Results: Gross and microscopic examination and ancillary studies were consistent with the diagnosis of intranodal schwannoma. The patient had acquired bilateral hypoacusia. Therefore, type 2 neurofibromatosis was considered and vestibular schwannomas ruled out. Conclusion: Herein, we present the second case of a primary schwannoma in a cervical lymph node reported so far. The relevance of the differential diagnosis is highlighted.
Blood group genotyping
Authors: Westhoff Connie M. 
Published: February 2019

AbstractGenomics is affecting all areas of medicine. In transfusion medicine, DNA-based genotyping is being used as an alternative to serological antibody-based methods to determine blood groups for matching donor to recipient. Most antigenic polymorphisms are due to single nucleotide polymorphism changes in the respective genes, and DNA arrays that target these changes have been validated by comparison with antibody-based typing. Importantly, the ability to test for antigens for which there are no serologic reagents is a major medical advance to identify antibodies and find compatible donor units, and can be life-saving. This review summarizes the evolving use and applications of genotyping for red cell and platelet blood group antigens affecting several areas of medicine. These include prenatal medicine for evaluating risk of fetal or neonatal disease and candidates for Rh-immune globulin; transplantation for bone marrow donor selection and transfusion support for highly alloimmunized patients and for confirmation of A2 status of kidney donors; hematology for comprehensive typing for patients with anemia requiring chronic transfusion; and oncology for patients receiving monoclonal antibody therapies that interfere with pretransfusion testing. A genomics approach allows, for the first time, the ability to routinely select donor units antigen matched to recipients for more than ABO/RhD to reduce complications. Of relevance, the growth of whole-genome sequencing in chronic disease and for general health will provide patients’ comprehensive extended blood group profile as part of their medical record to be used to inform selection of the optimal transfusion therapy.
Generation of synthetic dielectric dispersion logs in organic-rich shale formations using neural-network models
Authors: He Jiabo , Misra Siddharth 
Published: February 2019

Dielectric dispersion (DD) logs acquired in subsurface geologic formations generally are composed of conductivity ([Formula: see text]) and relative permittivity ([Formula: see text]) measurements at four discrete frequencies in the range of 10 MHz to 1 GHz. Acquisition of DD logs in subsurface formations is operationally challenging, and it requires a hard-to-deploy infrastructure. We developed three supervised neural-network-based predictive methods to process conventional, easy-to-acquire subsurface logs for generating the eight DD logs acquired at four frequencies. These predictive methods will improve reservoir characterization in the absence of a DD logging tool. The predictive methods are tested in three wells intersecting organic-rich shale formations of the Permian Basin and the Bakken Shale. The first method predicts the eight dispersion logs simultaneously using a single artificial neural network (ANN) model, whereas the second method simultaneously predicts the four conductivity dispersion logs using one ANN model, followed by simultaneous prediction of four permittivity dispersion logs using a second ANN model. The third method sequentially predicts the eight dispersion logs, one at a time using eight sequential ANN models, based on a predetermined ranking of the prediction accuracy for each of the eight DD logs when simultaneously generated. Considering that the conventional and DD logs are recorded more than 10,000 ft deep in the subsurface using logging tools that are run at different times in rugose boreholes for sensing the near-wellbore geologic formation, the data used in this predictive work is prone to noise and biases that tend to adversely affect the prediction performances of the proposed methods. In terms of normalized root-mean square error (Nrms error), the prediction performances of the second predictive method are 8.5% worse and 6.2% better for the conductivity and permittivity dispersion logs, respectively, as compared with those of the first predictive method. The third method has best prediction performance for permittivity dispersion logs, which is 0.089 in terms of the Nrms error.
Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma
Authors: Merchant Thomas E. , Bendel Anne E. , Sabin Noah D. , Burger Peter C. , Shaw Dennis W. , Chang Eric , Wu Shengjie , Zhou Tianni , Eisenstat David D. , Foreman Nicholas K. , Fuller Christine E. , Anderson Edwina Templeton , Hukin Juliette , Lau Ching C. , Pollack Ian F. , Laningham Fred H. , Lustig Robert H. , Armstrong Floyd D. , Handler Michael H. , Williams-Hughes Chris , Kessel Sandra , Kocak Mehmet , Ellison David W. , Ramaswamy Vijay 
Published: February 2019

PURPOSE The Children’s Oncology Group trial ACNS0121 estimated event-free survival (EFS) and overall survival for children with intracranial ependymoma treated with surgery, radiation therapy, and—selectively—with chemotherapy. Treatment was administered according to tumor location, histologic grade, and extent of resection. The impacts of histologic grade, focal copy number gain on chromosome 1q, and DNA methylation profiles were studied for those undergoing surgery and immediate postoperative conformal radiation therapy (CRT). METHODS ACNS0121 included 356 newly diagnosed patients (ages 1 to 21 years). Patients with classic supratentorial ependymoma were observed after gross total resection (GTR). Those undergoing subtotal resection received chemotherapy, second surgery, and CRT. The remaining patients received immediate postoperative CRT after near-total resection or GTR. CRT was administered with a 1.0-cm clinical target volume margin. The cumulative total dose was 59.4 Gy, except for patients who underwent GTR and were younger than age 18 months (who received 54 Gy). Patients were enrolled between October 2003 and September 2007 and were observed for 5 years. Supratentorial tumors were evaluated for RELA fusion; infratentorial tumors, for chromosome 1q gain. Classification of posterior fossa groups A and B was made by methylation profiles. RESULTS The 5-year EFS rates were 61.4% (95% CI, 34.5% to 89.6%), 37.2% (95% CI, 24.8% to 49.6%), and 68.5% (95% CI, 62.8% to 74.2%) for observation, subtotal resection, and near-total resection/GTR groups given immediate postoperative CRT, respectively. The 5-year EFS rates differed significantly by tumor grade ( P = .0044) but not by age, location, RELA fusion status, or posterior fossa A/posterior fossa B grouping. EFS was higher for patients with infratentorial tumors without 1q gain than with 1q gain (82.8% [95% CI, 74.4% to 91.2%] v 47.4% [95% CI, 26.0% to 68.8%]; P = .0013). CONCLUSION The EFS for patients with ependymoma younger than 3 years of age who received immediate postoperative CRT and for older patients is similar. Irradiation should remain the mainstay of care for most subtypes.
Theoretical Study on Hydrogen-Tritium Exchange Reactions between Several Organic and HTO Molecules: A Multicomponent QM Study
Authors: Ishibashi Rina , Tachikawa Masanori , Udagawa Taro 
Published: February 2019

Abstract
Hydrogen-tritium (H-T) exchange reactions between several organic and HTO molecules have been investigated using multicomponent M06-2X (MC_M06-2X)/6-311++G(d,p) method, which can directly take account of the nuclear quantum effect (NQE) of hydrogen nuclei. Transition state (TS) structures on the MC_M06-2X effective potential energy hypersurface are found with the aid of MC_M06-2X-climing image-nudged elastic band method. The relative energies of hydrogen-bonded complexes and the TS structures in hydrogen transfer reactions are clearly lowered by including NQE of proton or triton, while NQE of hydrogen nuclei hardly affects the potential energy profile along C-C or C-O rotational isomerization. Such difference arises from the different behaviors of the changes in spatial distribution of nuclear wavefunctions during reactions. Our present study clearly demonstrates that including NQE of hydrogen nuclei is indispensable to adequately analyze H-T exchange reactions between several organic and HTO molecules, or some reaction energy profiles cannot be represented even qualitatively.
A Special Connection between Nanofabrication and Analytical Devices: Chemical Lift-Off Lithography
Authors: Chen Chong-You , Wang Chang-Ming , Liao Wei-Ssu 
Published: February 2019

Abstract
Chemical lift-off lithography (CLL) is a chemo-topographical nanopatterning technique developed in 2012 which provides not only precise geometry control with sub-20 nm resolution, but also sharp material interface environment adjustments. Unlike most fabrication techniques, this approach builds a straightforward bridge between structure generation and analytical device designs. This property lies on a direct molecular pattern creation on a metal surface, where the produced unique interface environment acts as a supporting matrix for diverse analytical tools. Operation of CLL includes stamp activation, self-assembled monolayer formation, conformal sealing, and finally interface molecule lift-off. Creation of molecular patterns is achieved by using stamps casting with structures, and a featureless master generates active surfaces capable of arbitrary functionalization. The post lift-off areas present an environment distributed with residual molecules, and its composition can be well-tuned by interface reaction conditions and monolayer selection. Connections between CLL and analytical devices initiate from this point, where tools such as functional probe anchoring, microscopy, high-throughput microfluidics, and spectroscopy can all be integrated. This paper outlines the ideas behind CLL and connections to analytical devices, where invention background introduction, unique molecular environment discussion, modern platform demonstration, challenges in the future, and exciting perspective work in coming years are all included.