bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of peptide nanotubes for fabricating a new type of bio-functional textiles
Authors: Shakeri Mina , Hemmatinejad Nahid , Bashari Azadeh 
Published: March 2018

Peptides are one of the most important biological molecules which can be used in drug delivery applications. Peptides are composed of amino acids and are connected together by a peptide bond. These biomaterials have drawn lots of attention in recent years because of their biocompatibility, antibacterial effect, and medical and clinical applications. In this paper, phenylalanine amino acid is used to synthesize peptide nanotubes. The method used for synthesis of peptide nanotubes was self-assembly which is efficient and spontaneous. According to the experimental evaluations of peptide nanotubes, the best concentration of amino acid solution for peptide nanotubes synthesis was 0.005 mg/ml. In this concentration, the tubes show their hollow, long structure. The average diameter of the tubes is 120 nanometer and they have an aspect ratio of 45. To investigate the drug releasing ability of nanotubes, ascorbic acid solution was loaded on them. The solution was applied on cotton fabric to examine the possibility of producing cosmetotextiles. The ability of cotton fabrics to release ascorbic acid in different temperatures and mediums were examined using different conditions. UV-Visible spectroscopy was also used to measure the amount of ascorbic acid release from peptide nanotubes. The antibacterial test was also carried out to determine the antibacterial activity of amino acid molecules on cotton fabric.
Myo- and cardiotoxic effects of the wild winter mushroom (Flammulina velutipes) on mice
Authors: Mustonen Anne-Mari , Määttänen Maija , Kärjä Vesa , Puukka Katri , Aho Jari , Saarela Seppo , Nieminen Petteri 
Published: March 2018

Rhabdomyolysis (destruction of striated muscle) is a novel form of mushroom poisoning in Europe and Asia indicated by increased circulating creatine kinase levels. Particular wild fungi have also been reported to induce elevated creatine kinase activities in mice. Flammulina velutipes (enokitake or winter mushroom) is one of the most actively cultivated mushroom species globally. As it is marketed as a medicinal mushroom and functional food, it is important to examine whether it could induce potentially harmful health effects similar to some previously studied edible fungi. The present study examined the effects of F. velutipes consumption on the plasma clinical chemistry, hematology, and organ histology of laboratory mice. Wild F. velutipes were dried, pulverized, mixed with a regular laboratory rodent diet, and fed to the animals at 0, 3, 6, or 9 g/kg body mass/day for five days ( n = 6/group). F. velutipes consumption caused increased activities of plasma creatine kinase and the MB-fraction of creatine kinase at 6–9 g/kg/d, indicating potentially deleterious effects on both skeletal and cardiac muscle. The plasma total and high-density lipoprotein cholesterol concentrations (at 9 g/kg/d) and white blood cell and lymphocyte counts (at 6–9 g/kg/d) decreased. Although the cholesterol-lowering properties of F. velutipes can be beneficial, the previously unexamined, potentially hazardous side effects of mushroom consumption (myo- and cardiotoxicity) should be thoroughly investigated before recommending this mushroom species as a health-promoting food item. Impact statement This work is important to the field of functional foods, as it provides novel information about the potential myo- and cardiotoxic properties of an edible mushroom, Flammulina velutipes. The results are useful and of importance because F. velutipes is an actively cultivated mushroom and marketed as a health-promoting food item. The findings contribute to the understanding of the complexity of the balance between the beneficial and potentially harmful effects of mushroom consumption.
Biology of classical Hodgkin lymphoma: implications for prognosis and novel therapies
Authors: Mottok Anja , Steidl Christian 
Published: March 2018

AbstractHodgkin lymphoma is considered a prime example of treatment success, with cure rates exceeding 80% using modern combined modality therapies. However, especially in adolescents and young adults, treatment-related toxicity and long-term morbidity still represent persistent challenges. Moreover, outcomes in patients with relapsed or refractory disease remain unfavorable in the era of high-dose chemotherapy and stem-cell transplantation. Hence, there is a high demand for novel and innovative alternative treatment approaches. In recent years, many new therapeutic agents have emerged from preclinical and clinical studies that target molecular hallmarks of Hodgkin lymphoma, including the aberrant phenotype of the tumor cells, deregulated oncogenic pathways, and immune escape. The antibody-drug conjugate brentuximab vedotin and immune checkpoint inhibitors have already shown great success in patients with relapsed/refractory disease, leading to US Food and Drug Administration approval and new trials testing these agents in various clinical settings. The expanding knowledge and understanding of Hodgkin lymphoma biology and disease progression, as well as the development of robust tools for biomarker-driven risk stratification and therapeutic decision making, continue to be fundamentally important for the success of these and other novel agents. We anticipate that the availability and clinical implementation of novel molecular assays will be instrumental in an era of rapid shifts in the treatment landscape of this disease. Here, we review the current knowledge of Hodgkin lymphoma pathobiology, highlighting the related development of novel treatment strategies and prognostic models that hold the promise to continually challenge and change the current standard of care in classical Hodgkin lymphoma.
Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium
Authors: Sacharidou Anastasia , Chambliss Ken L. , Ulrich Victoria , Salmon Jane E. , Shen Yu-Min , Herz Joachim , Hui David Y. , Terada Lance S. , Shaul Philip W. , Mineo Chieko 
Published: March 2018

Key PointsThe activation of PP2A in endothelium underlies thrombus formation induced by aPL in mice. Endothelial apoER2 serves as a scaffold for aPL-induced assembly of a Dab2 and SHC1- containing complex that assembles and activates PP2A.
Next-generation sequencing of idiopathic multicentric and unicentric Castleman disease and follicular dendritic cell sarcomas
Authors: Nagy Alexandra , Bhaduri Aparna , Shahmarvand Nahid , Shahryari Jahanbanoo , Zehnder James L. , Warnke Roger A. , Mughal Tariq , Ali Siraj , Ohgami Robert S. 
Published: March 2018

Key PointsA single rare DNMT3A mutation and recurrent amplification of ETS1, PTPN6, and TGFBR2 are identified in iMCD and UCD. Genetic alterations in oncogenes, tumor suppressors, and chromatin-remodeling genes are seen in FDCS.
RETRACTED ARTICLE: The suppressing role of miR-622 in renal cell carcinoma progression by down-regulation of CCL18/MAPK signal pathway
Authors: Li Tian , Sun Xiangzhou , Xu Kewei 
Published: March 2018

Abstract
Background
MicroRNAs have emerged as critical modulators of carcinogenesis and tumor progression including renal cell carcinoma (RCC). MiR-622 plays as a tumor inhibitor in some types of cancer, however, its role in kidney cancer is unknown. The purpose of the present work is to investigate the functional behaviors and regulatory mechanism of miR-622 in RCC.

Results
We examined the expression of miR-622 in RCC and adjacent normal tissues and then explored the roles of miR-622. The results of this analysis indicated that miR-622 activity was significantly downregulated in RCC tissues compared with the corresponding normal tissues, so did in RCC cell lines. MiR-622 was associated with RCC aggressiveness. MiR-622 in RCC cells decreased CCL18 expression and suppressed CCL18 activated MAPK signal pathway. Using Western blot and luciferase reporter assays, it was verified that CCL18 was a direct target of miR-622. A specific and inverse correlation between miR-622 and CCL18 expression was found in human RCC samples.

Conclusions
The results demonstrated that miR-622 acted as a tumor-promoting miRNA by targeting CCL18 in RCC.
Patient perspectives on repeated MRI and PET/CT examinations during neoadjuvant treatment of esophageal cancer
Authors: Goense Lucas , Borggreve Alicia S , Heethuis Sophie E , van Lier Astrid LHMW , van Hillegersberg Richard , Mook Stella , Meijer Gert J , van Rossum Peter SN , Ruurda Jelle P 
Published: March 2018

Objective:
The perceived burden of diagnostic tests by patients during the assessment of esophageal cancer warrants attention with the current increase in repeated imaging for purposes of disease monitoring during and after treatment. The purpose of this prospective study was to evaluate the experienced burden associated with repeated MRI and positron emission tomography with integrated CT (PET/CT) examinations during neoadjuvant treatment for esophageal cancer from the perspective of the patient.

Methods:
In 27 patients receiving neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer MRI and PET/CT examinations were performed before nCRT, during nCRT and before surgery. The experienced burden during repeated MRI and PET/CT examinations was evaluated with a self-report questionnaire addressing discomfort, pain, anxiety and embarrassment, each measured on a 5-point Likert scale (1 = none; up to 5 = very much). In addition, a comparative assessment was used to rank MRI, PET/CT and baseline endoscopy.

Results:
All scans were performed without the occurrence of an adverse event. Few patients experienced discomfort (mean score ±SD: 1.9 ± 1.0 for MRI v s 2.0 ± 1.0 for PET/CT, p = 0.586), pain (1.1 ± 0.4 for MRI v s 1.3 ± 0.7 for PET/CT, p = 0.059), anxiety (1.0 ± 0.2 for MRI v s 1.0 ± 0.2 for PET/CT, p = 1.000) and embarrassment (1.0 ± 0 for MRI v s 1.0 ± 0.2 for PET/CT, p = 0.317) during both MRI and PET/CT. Patients preferred MRI over PET/CT (67% vs 22%, respectively, p = 0.023), and MRI over endoscopy (59% vs 19%, respectively, p = 0.027). In the comparison between PET/CT and endoscopy, 59% of patients preferred PET/CT and 26% preferred endoscopy (p = 0.093).

Conclusion:
Repeated imaging with both MRI and PET/CT is generally well-tolerated for the assessment of response to treatment in esophageal cancer patients. Shorter acquisition times and altered body positioning during scanning will likely improve patient experience.

﻿Advances in knowledge:
This paper demonstrates that MRI and PET/CT are generally well-tolerated imaging procedures for the assessment of response to treatment in esophageal cancer patients. When asked to rank different tests, patients preferred MRI over PET/CT and endoscopy.
18F-FDG PET/CT in the management of patients with malignant pleural mesothelioma being considered for multimodality therapy: experience of a tertiary referral center
Authors: Elliott Hugh S , Metser Ur , de Perrot Marc , Cho John , Bradbury Penelope , Veit-Haibach Patrick , Hussey Douglas , Noam Tau 
Published: March 2018

Objective:
To compare the N- and M-staging accuracy of PET v s CT, as per the American Joint Committee on Cancer (AJCC) eighth edition in patients with malignant pleural mesothelioma (MPM) being considered for multimodality therapy in a tertiary referral center. A secondary aim was to assess survival outcome of patients chosen for surgical management after PET.

Methods:
A retrospective, single institution comparison of PET and CT was performed in patients with histologically proven MPM being considered for multimodality therapy. Performance of each modality in identifying nodal category and presence or absence of distant metastases was abstracted from electronic patient records. The standard of reference was surgical histopathology for nodal stage and histopathology or clinical and imaging follow-up of &gt;3 months for distant metastases.

Results:
There were 101 eligible patients with complete data sets; 82 males, 19 females with a mean age of 66.6 years (range: 39–85). Most patients (n = 68) had epithelioid histology. Surgery was performed in 61/101 patients (60.4%), most of whom had multimodality therapy. Nodal category was concordant to surgical histopathology in 38/60 patients (63.3%) on PET, compared to 27/60 (45%) on CT (p = 0.001). For detection of ≥N1 disease only, PET and CT correctly staged 15/37 patients (40.5%) and 8/37 (21.6%), respectively (p = 0.023). Distant metastases were identified uniquely on PET in eight patients and on CT only in one patient. Overall, PET and CT correctly identified 11/12 (91.6%) and 4/12 (33.3%) patients with distant metastases, respectively (p = 0.0391).

Conclusion:
PET identifies significantly more patients with nodal or distant metastatic disease than CT and may contribute to more appropriate selection of patients with MPM for surgery or multimodality therapy.

Advances in knowledge:
In patients with MPM, fludeoxyglucose-PET/CT detects significantly more patients with distant metastases than CT. PET/CT can help in the selection of patients with MPM who would benefit from surgery or multimodality therapy.
Quantifying changes in nigrosomes using quantitative susceptibility mapping and neuromelanin imaging for the diagnosis of early-stage Parkinson’s disease
Authors: Takahashi Hiroto , Watanabe Yoshiyuki , Tanaka Hisashi , Mihara Masahito , Mochizuki Hideki , Liu Tian , Wang Yi , Tomiyama Noriyuki 
Published: March 2018

Objective:
To quantify nigral changes with a focus on their spatial variation within the substantia nigra pars compacta (SNpc) for diagnosing early-stage Parkinson’s disease (PD).

Methods:
The study participants were 18 patients with early-stage PD (PD group) and 18 healthy controls (HC group) who underwent quantitative susceptibility mapping (QSM) and neuromelanin imaging. The QSM and neuromelanin values in each whole SNpc containing the entire nigrosome and dorsolateral SNpc containing nigrosome 1 were calculated. The neuromelanin area was defined as the volume with a signal-to-noise ratio higher than that of the background region. The significance of intergroup differences in the QSM value and neuromelanin area in each SNpc region was tested. Logit (p) was used to estimate the probability of PD in relation to the QSM value and the neuromelanin area, and receiver operating characteristic analyses were performed for each value.

Results:
In both SNpc, QSM values were significantly higher and neuromelanin areas were significantly lower in the PD group compared with the HC group (p &lt; 0.05). The respective areas under the receiver operating characteristic curve for the two groups were 0.70/0.73 for the QSM value, 0.81/0.78 for the neuromelanin area in the whole/dorsolateral SNpc, and 0.86 for logit (p) in relation to the QSM value of the dorsolateral SNpc and the neuromelanin area of the whole SNpc.

Conclusion:
Comprehensive MRI assessment of the abnormality involving the nigrosomes can yield a high diagnostic performance for early-stage PD.

Advances in knowledge:
Focusing on spatial differences in nigral changes within the SNpc can increase the sensitivity of the detection of PD-related neurodegenerative changes.
On Direct vs. Indirect Peer Influence in Large Social Networks
Authors: Zhang Bin , Pavlou Paul A. , Krishnan Ramayya 
Published: March 2018

With the availability of large-scale network data, peer influence in social networks can be more rigorously examined and understood than before. Peer influence can arise from immediate neighbors in the network (formally defined as cohesion or direct ties with one-hop neighbors) and from indirect peers who share common neighbors (formally defined as structural equivalence or indirect ties with two-hop neighbors). While the literature examined the role of each peer influence (direct or indirect) separately, the study of both peer network effects acting simultaneously was ignored, largely because of methodological constraints. This paper attempts to fill this gap by evaluating the simultaneous effect of both direct and indirect peer influences in technology adoption in the context of caller ringback tone (CRBT) in a cellular telephone network, using data from 200 million calls by 1.4 million users. Given that such a large-scale network makes traditional social network analysis intractable, we extract many densely connected and self-contained subpopulations from the network. We find a regularity in these subpopulations in that they consist either of about 200 nodes or about 500 nodes. Using these subpopulations and panel data, we analyze direct and indirect peer influences using a novel autoprobit model with multiple network terms (direct and indirect peer influence, with homophily as a control variable). Our identification strategy relies on a newly designed spatial autoregressive model, allowing us to identify the direct and indirect peer influences on each of the extracted subpopulations. We use meta-analysis to summarize the estimated parameters from all subpopulations. The results show CRBT adoption to be simultaneously determined by both direct and indirect peer influence (while controlling for homophily and centrality). Robustness checks show model fit to improve when both peer influences are included. The size and direction of the two peer influences, however, differ by group size. Interestingly, indirect peer influence (structural equivalence) plays a negative role in diffusion when group size is about 200, but a positive role when group size is about 500. The role of direct peer influence (cohesion), on the other hand, is always positive, irrespective of group size. Our findings imply that businesses must design different target strategies for large versus small groups: for large groups, businesses should focus on consumers with both multiple one-hop and two-hop neighbors; for small groups, businesses should only focus on consumers with multiple one-hop neighbors. The online appendix is available at https://doi.org/10.1287/isre.2017.0753 .
Differential Firm Commitment to Industries Supported by Social Movement Organizations
Authors: Durand Rodolphe , Georgallis Panayiotis (Panikos) 
Published: March 2018

This article theorizes about and tests the conditions under which firms’ commitment to an industry is influenced by social movement organizations (SMOs) that favor the industry. We argue that the more prominent SMOs are within an industry, the more a firm increases its commitment to that industry by expanding its operations; yet, this main effect should be moderated substantially by a firm’s idiosyncratic characteristics. The current research predicts that a firm’s location, its sensitivity to information about the industry’s potential, and its history of associations with activists determine the magnitude of the effect of SMO prominence on its strategic commitment to the industry. We test and find support for these hypotheses using a longitudinal data set of European manufacturers of solar photovoltaic cells between 1990 and 2011. The findings offer new insights for literature on social movements and organizations, as well as strategic management research. The online appendix is available at https://doi.org/10.1287/orsc.2017.1170 .
Analysis of the catfish (clarias sp.) value chain and its problems in Bogor, Indonesia
Authors: Bulkini Asep , Satria Arif , Mulyati Heti 
Published: March 2018

Catfish is one of the leading freshwater commodities stipulated by the Ministry of Marine Affairs and Fisheries (KKP) of the Republic of Indonesia. The annual production target of catfish continues to increase every year. This study aims to analyze the actors and the value chain map of catfish, problems in the value chain of catfish, and the strategies to improve the value chain. This research was conducted by survey method using questionnaire instrument. The survey was done by using purposive sampling technique to 23 catfish farmers, 7 catfish wholesalers, 5 catfish retailers, and 5 catfish processors in Bogor Regency. In this study, there are 4 channels of the value chain of catfish from the production to the consumer. The four actors who are involved in the value chain, namely farmer, wholesaler, retailer, and processor. The constraints along the value chain consist of three aspects: pre-production, production, and post-harvest. Pre-production problems include thequality of seeds, high price of feed, and lack of capital. Problems on production are the weather, fish mortality, and social security. Problems facing post-production cover price instability and lack of bargaining power of farmers. Proposed up-grading strategies to improve the competitiveness are strengthening partnership among farmers, strengthening partnerships between farmers and other strategic partners (traders, and feed companies).
Investigating the impact of ceo’s social network on sme performance and access to external resources in the moroccan textile industry
Authors: Adama Tahirou Younoussi Meda , Nadif Mohammed 
Published: March 2018

This paper analyses the relationship between the social network dimensions, the performance of Moroccan SMEs of the textile industry and their access to external resources. As these companies face a fierce competition in recent years, their CEOs’ social networks are playing a significant role in their success and survival. Through a sample of 112 SMEs and a quantitative method, our results show that the more the network is important, the more it promotes SME performance and access to information resources, that having closer tie with the bankers allows a better access to financial resources, that knowing and having links with people in high places is a privilege and contributes effectively to an organizational performance.
Identification of Bacillus spp. colonizing the nasal mucosa of healthy adults living in the suburban area using the matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) system
Authors: Kosikowska Urszula , Stepien-Pysniak Dagmara , Ozga Dorota , Wernicki Andrzej , Malm Anna 
Published: March 2018

ABSTRACT
Bacillus spp. can be regarded as a rare component of the nasal mucosa microflora. The aim of this study was to identify Bacillus spp. from the nasal mucosa of healthy adults living in the suburban area near Lublin using the matrix-assisted laser desorptionionization time-of-flight mass spectrometry (MALDI-TOF MS) system.
A total of 11 bacterial isolates from the nasal specimens were cultured. The following species were identified using the routine microbiological methods: Staphylococcus aureus (3 isolates), S. epidermidis (1 isolate), S. intermedius (1 isolate) and Staphylococcus spp. (1 isolate). Moreover, 2 strains of Escherichia coli were isolated. Besides, 3 isolates of Bacillus spp. were found. These isolates were characterized by means of MALDI-TOF MS, resulting in highly specific mass spectral fingerprints and these were identified as B. pumilus, B. safenis and B. licheniformis. It was observed that all studied Bacillus spp. isolates only had the masses in common at 3864 ± 2, 7727 ± 2, and 14301 ± 4. The spectra of B. safensis and B. pumilus showed peaks at m/z 4914 ± 3, 6621 ± 3 and 14291 ± 2, which were absent in the spectrum of B. licheniformis. For B. safenis and B. pumilus, other potential biomarkers could be found at m/z 12620 and 16668, respectively.