bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-dimensional distributed semantic spaces for utterances
Authors: Karlgren Jussi , Kanerva Pentti 
Published: July 2019

AbstractHigh-dimensional distributed semantic spaces have proven useful and effective for aggregating and processing visual, auditory and lexical information for many tasks related to human-generated data. Human language makes use of a large and varying number of features, lexical and constructional items as well as contextual and discourse-specific data of various types, which all interact to represent various aspects of communicative information. Some of these features are mostly local and useful for the organisation of, for example, argument structure of a predication; others are persistent over the course of a discourse and necessary for achieving a reasonable level of understanding of the content.This paper describes a model for high-dimensional representation for utterance and text-level data including features such as constructions or contextual data, based on a mathematically principled and behaviourally plausible approach to representing linguistic information. The implementation of the representation is a straightforward extension of Random Indexing models previously used for lexical linguistic items. The paper shows how the implementedmodel is able to represent a broad range of linguistic features in a common integral framework of fixed dimensionality, which is computationally habitable, and which is suitable as a bridge between symbolic representations such as dependency analysis and continuous representations used, for example, in classifiers or further machine-learning approaches. This is achieved with operations on vectors that constitute a powerful computational algebra, accompanied with an associative memory for the vectors. The paper provides a technical overview of the framework and a worked through implemented example of how it can be applied to various types of linguistic features.
Internal Energy Dissipation in Enceladus's Subsurface Ocean From Tides and Libration and the Role of Inertial Waves
Authors: Rekier J. , Trinh A. , Triana S. A. , Dehant V. 
Published: July 2019

AbstractEnceladus is characterized by a south polar hot spot associated with a large outflow of heat, the source of which remains unclear. We compute the heat generated via viscous dissipation resulting from tidal and (longitudinal) libration forcing in the moon's subsurface ocean using the linearized Navier‐Stokes equation in a three‐dimensional spherical model. We conclude that libration is the dominant cause of dissipation at the linear order, providing up to ∼0.001 GW of heat to the ocean, which remains insufficient to explain the ∼10 GW observed by Cassini. We also illustrate how resonances with inertial modes can significantly augment the dissipation. Our work is an extension to Rovira‐Navarro et al. (2019, https://doi.org/10.1016/j.icarus.2018.11.010) to include the effects of libration and the presence of the icy crust. The model developed here is readily applicable to the study of other moons with a subsurface ocean and planets with a liquid core.
Overlooked electrolyte destabilization by manganese (II) in lithium-ion batteries
Authors: Wang Cun , Xing Lidan , Vatamanu Jenel , Chen Zhi , Lan Guangyuan , Li Weishan , Xu Kang 
Published: July 2019

AbstractTransition-metal dissolution from cathode materials, manganese in particular, has been held responsible for severe capacity fading in lithium-ion batteries, with the deposition of the transition-metal cations on anode surface, in elemental form or as chelated-complexes, as the main contributor for such degradations. In this work we demonstrate with diverse experiments and calculations that, besides interfacial manganese species on anode, manganese(II) in bulk electrolyte also significantly destabilizes electrolyte components with its unique solvation-sheath structure, where the decompositions of carbonate molecules and hexafluorophosphate anion are catalyzed via their interactions with manganese(II). The manganese(II)-species eventually deposited on anode surface resists reduction to its elemental form because of its lower electrophilicity than carbonate molecule or anion, whose destabilization leads to sustained consumption. The reveal understanding of the once-overlooked role of manganese-dissolution in electrolytes provides fresh insight into the failure mechanism of manganese-based cathode chemistries, which serves as better guideline to electrolyte design for future batteries.
Development of high-resolution daily gridded temperature datasets for the central north region of Egypt
Authors: Nashwan Mohamed Salem , Shahid Shamsuddin , Chung Eun-Sung 
Published: July 2019

AbstractThis study developed 0.05° × 0.05° land-only datasets of daily maximum and minimum temperatures in the densely populated Central North region of Egypt (CNE) for the period 1981–2017. Existing coarse-resolution datasets were evaluated to find the best dataset for the study area to use as a base of the new datasets. The Climate Prediction Centre (CPC) global temperature dataset was found to be the best. The CPC data were interpolated to a spatial resolution of 0.05° latitude/longitude using linear interpolation technique considering the flat topography of the study area. The robust kernel density distribution mapping method was used to correct the bias using observations, and WorldClim v.2 temperature climatology was used to adjust the spatial variability in temperature. The validation of CNE datasets using probability density function skill score and hot and cold extremes tail skill scores showed remarkable improvement in replicating the spatial and temporal variability in observed temperature. Because CNE datasets are the best available high-resolution estimate of daily temperatures, they will be beneficial for climatic and hydrological studies.
The posterior Cerebellum is involved in constructing Social Action Sequences: An fMRI Study
Authors: Heleven Elien , van Dun Kim , Van Overwalle Frank 
Published: July 2019

AbstractSocial neuroscience largely ignored the role of the cerebellum, despite its implications in a broad range of tasks and neurological disorders related to social functioning and inferences on others’ mental state such as beliefs. One hypothesis states that during human evolution, the cerebellum’s function evolved from a mere coordinator of fluent sequences of motions and actions, to an interpreter of action sequences without overt movements that are important for social understanding. The present study introduces new tasks to investigate the role of the cerebellum in sequencing, in which participants generated the correct chronological order of new or well-known event stories with or without social elements during functional neuroimaging (fMRI). Results showed strong cerebellar activation during order generation for all event types compared to passive viewing or reading events. More importantly, new social events involving true or false beliefs showed stronger activation in the bilateral posterior cerebellum (Crus 1 and Crus 2) compared to routine social and non-social (mechanical) events. This confirms the critical role of the posterior cerebellum in the understanding and construction of the correct order of action sequences relevant for social understanding. The present tasks and results may facilitate diagnoses and treatments of cerebellar dysfunctions in the future.
Enterovirus 71 targets the cardiopulmonary system in a robust oral infection mouse model
Authors: Chang Chih-Shin , Liao Chun-Che , Liou An-Ting , Chang Ya-Shu , Chang Ya-Ting , Tzeng Bing-Hsiean , Chen Chien-Chang , Shih Chiaho 
Published: July 2019

AbstractSevere infection with the re-emerging enterovirus 71 (EV71 or EV-A71) can cause cardiopulmonary failure. However, in patients’ heart and lung, viral protein has not been detected. In mouse models, heart disease has not been reported. EV71-infected brainstem is generally believed to be responsible for the cardiopulmonary collapse. One major limitation in EV71 research is the lack of an efficient oral infection system using non-mouse-adapted clinical isolates. In a robust oral infection NOD/SCID mouse model, we detected EV71 protein at multiple organs, including heart and lung, in 100% of moribund mice with limb paralysis. Infiltrating leukocytes were always detected in heart and muscle, and VP1-positive M2 macrophages were abundant in the lung. Functional dissection on the pathogenesis mechanism revealed severe apoptosis, inflammatory cytokines, and abnormal electrocardiogram (EKG) in orally infected hearts. Therefore, cardiopulmonary disease could be one plausible cause of death in this mouse model. Inoculation of EV71 through an oral route resulted in viral infection in the intestine, viremia, and EV71 appeared to spread to peripheral tissues via blood circulation. Infectious virus was no longer detected in the blood on day 5 post-infection by the plaque formation assay. We demonstrated that both EV71 clinical isolate and cloned virus can target the cardiopulmonary system via a natural infection-like oral route.
Defibrotide enhances fibrinolysis in human endotoxemia – a randomized, double blind, crossover trial in healthy volunteers
Authors: Schoergenhofer Christian , Buchtele Nina , Gelbenegger Georg , Derhaschnig Ulla , Firbas Christa , Kovacevic Katarina D. , Schwameis Michael , Wohlfarth Philipp , Rabitsch Werner , Jilma Bernd 
Published: July 2019

AbstractDefibrotide is approved for the treatment of sinusoidal obstruction syndrome after allogeneic stem cell transplantation. The exact mode of action of defibrotide is unclear and humanin vivodata are scarce. In this randomized, double blind, crossover trial we included 20 healthy volunteers. Four were randomized to receive placebo, while 16 received a 2 ng/kg bodyweight bolus of lipopolysaccharide (LPS). Infusion of 6.25 mg/kg defibrotide or placebo was started one hour before the injection of the LPS bolus. Plasma levels of prothrombin fragments F1 + 2, thrombin-antithrombin complexes, von Willebrand factor, E-selectin, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), plasmin-antiplasmin complexes (PAP), tumor necrosis factor-α, interleukin 6, and C-reactive protein were measured. Thromboelastometry was performed. Infusion of defibrotide did not reduce the LPS-induced activation of coagulation, the endothelium or the release of pro-inflammatory cytokines. However, defibrotide increased t-PA antigen levels by 31% (Quartiles: 2–49%, p = 0.026) and PAP concentrations by 13% (−4–41%, p = 0.039), while PAI-1 levels remained unaffected. Moreover, defibrotide reduced C-reactive protein levels by 13% (0–17%, p = 0.002). A transient increase in the clotting time in thromboelastometry and a decrease in F1 + 2 prothrombin fragments suggests modest anticoagulant properties. In conclusion, defibrotide infusion enhanced fibrinolysis and reduced C-reactive protein levels during experimental endotoxemia.
Structural basis of glycogen metabolism in bacteria
Authors: Cifuente Javier O. , Comino Natalia , Trastoy Beatriz , D'Angelo Cecilia , Guerin Marcelo E. 
Published: July 2019

Abstract
The evolution of metabolic pathways is a major force behind natural selection. In the spotlight of such process lies the structural evolution of the enzymatic machinery responsible for the central energy metabolism. Specifically, glycogen metabolism has emerged to allow organisms to save available environmental surplus of carbon and energy, using dedicated glucose polymers as a storage compartment that can be mobilized at future demand. The origins of such adaptive advantage rely on the acquisition of an enzymatic system for the biosynthesis and degradation of glycogen, along with mechanisms to balance the assembly and disassembly rate of this polysaccharide, in order to store and recover glucose according to cell energy needs. The first step in the classical bacterial glycogen biosynthetic pathway is carried out by the adenosine 5′-diphosphate (ADP)-glucose pyrophosphorylase. This allosteric enzyme synthesizes ADP-glucose and acts as a point of regulation. The second step is carried out by the glycogen synthase, an enzyme that generates linear α-(1→4)-linked glucose chains, whereas the third step catalyzed by the branching enzyme produces α-(1→6)-linked glucan branches in the polymer. Two enzymes facilitate glycogen degradation: glycogen phosphorylase, which functions as an α-(1→4)-depolymerizing enzyme, and the debranching enzyme that catalyzes the removal of α-(1→6)-linked ramifications. In this work, we rationalize the structural basis of glycogen metabolism in bacteria to the light of the current knowledge. We describe and discuss the remarkable progress made in the understanding of the molecular mechanisms of substrate recognition and product release, allosteric regulation and catalysis of all those enzymes.
Artificial intelligence for microscopy: what you should know
Authors: von Chamier Lucas , Laine Romain F. , Henriques Ricardo 
Published: July 2019

Abstract
Artificial Intelligence based on Deep Learning (DL) is opening new horizons in biomedical research and promises to revolutionize the microscopy field. It is now transitioning from the hands of experts in computer sciences to biomedical researchers. Here, we introduce recent developments in DL applied to microscopy, in a manner accessible to non-experts. We give an overview of its concepts, capabilities and limitations, presenting applications in image segmentation, classification and restoration. We discuss how DL shows an outstanding potential to push the limits of microscopy, enhancing resolution, signal and information content in acquired data. Its pitfalls are discussed, along with the future directions expected in this field.
Short-Term Complications following Single-Session versus Staged Bilateral Tibial Plateau Levelling Osteotomies Stabilized with Locking Plates for Treatment of Bilateral Cranial Cruciate Ligament Disease: A Retrospective Study
Authors: Cappelle Kelsey K. , Barnhart Matthew D. 
Published: July 2019

Objective The aim of this study was to compare complications between dogs with bilateral cranial cruciate ligament disease treated with single-session bilateral tibial plateau levelling osteotomies (BSSTPLO) versus staged bilateral TPLO (STPLO) procedures stabilized with locking plates.
Study Design Medical records of client-owned dogs treated with BSSTPLO or STPLO stabilized with locking plates between March 2017 and July 2018 at two associated institutions were reviewed. Patient data and complications from 37 dogs with BSSTPLO and 18 with STPLO were compared between groups. Major complications were defined as any complication that required further surgical or medical treatment whereas minor complications did not.
Results Incidence for major complications for BSSTPLO and STPLO was 7/37 and 6/18 respectively. Incidence for minor complications for BSSTPLO and STPLO was 3/37 and 2/18 respectively. No significant differences in minor or major complication rates existed between study groups (p = 0.2). Mean body weight was significantly higher in the STPLO group (p = 0.001); however, no correlation between weight or BCS and complication rate existed within either group. Increasing age was the only significant risk factor for major complications (p = 0.01) in either group.
Conclusion Our findings support the claim that BSSTPLO and STPLO performed with locking implants have similar complication rates. The decision to perform BSSTPLO or STPLO in dogs with bilateral cranial cruciate ligament disease should be based on other considerations rather than just complication rates.
Study of Bernard–Soulier Syndrome Megakaryocytes and Platelets Using Patient-Derived Induced Pluripotent Stem Cells
Authors: Mekchay Ponthip , Ingrungruanglert Praewphan , Suphapeetiporn Kanya , Sosothikul Darintr , Ji-au Wilawan , Maneesri Le Grand Supang , Israsena Nipan , Rojnuckarin Ponlapat 
Published: July 2019

AbstractBernard–Soulier syndrome (BSS) is a hereditary macrothrombocytopenia caused by defects in the glycoprotein (GP) Ib-IX-V complex. The mechanism of giant platelet formation remains undefined. Currently, megakaryocytes (MKs) can be generated from induced pluripotent stem cells (iPSCs) to study platelet production under pharmacological or genetic manipulations. Here, we generated iPSC lines from two BSS patients with mutations in different genes (GP1BA and GP1BB: termed BSS-A and BSS-B, respectively). The iPSC-derived MKs and platelets were examined under electron microscopy and stained by immunofluorescence to observe proplatelet formation and measure platelet diameters which were defined by circumferential tubulin. BSS-iPSCs produced abnormal proplatelets with thick shafts and tips. In addition, compared with the normal iPSCs, the diameters were larger in platelets derived from BSS-A and BSS-B with the means ± standard deviations of 4.34 ± 0.043 and 3.88 ± 0.045 µm, respectively (wild-type iPSCs 2.61 ± 0.025 µm, p < 0.001). Electron microscopy revealed giant platelets with the abnormal demarcation membrane system. Correction of BSS-A and BSS-B-iPSCs using lentiviral vectors containing respective GP1BA and GP1BB genes improved proplatelet structures and platelet ultrastructures as well as reduced platelets sizes. In conclusion, the iPSC model can be used to explore molecular mechanisms and potential therapy for BSS.
A Multisite Examination of Everyday Discrimination and the Prevalence of Spontaneous Preterm Birth in African American and Latina Women in the United States
Authors: Fryer Kimberly E. , Vines Anissa I. , Stuebe Alison M. 
Published: July 2019

Abstract
Objective African American women have a higher risk of spontaneous preterm birth than White and Latina women. Although Latina women are exposed to similar social determinants of health, they have lower rates of spontaneous preterm birth. One theory for this difference is the maternal stress biological pathway, whereby lifetime stressors, such as racial discrimination, lead to a premature activation of parturition. We investigated the prevalence of self-reported discrimination and its association with the prevalence of spontaneous preterm birth.
Study Design Using data from the Community Child Health Research Network Study, a multisite cohort study from 2008 to 2012, we conducted a cross-sectional analysis of 1,154 African American women and 578 Latina women.
Results Adjusting for multiple risk factors, African American and Latina women who experienced the highest tertile of discrimination had a higher prevalence of preterm birth compared with those who experienced discrimination less than once per year, adjusted hazard ratio (aHR) = 1.5 (0.7–3.1) and 3.6 (0.9–14.4), respectively.
Conclusion In our cohort, we found a statistically significant association only in the medium discrimination group in Latina women, but we did not find a statistically significant association in African American women. Reduction in experienced discrimination may be an important intervention for reducing adverse pregnancy outcomes.
Team Stress and Adverse Events during Neonatal Tracheal Intubations: A Report from NEAR4NEOS
Authors: Umoren Rachel A. , Sawyer Taylor L. , Ades Anne , DeMeo Stephen , Foglia Elizabeth E. , Glass Kristen , Gray Megan M. , Barry James , Johnston Lindsay , Jung Philipp , Kim Jae H. , Krick Jeanne , Moussa Ahmed , Mulvey Christine , Nadkarni Vinay , Napolitano Natalie , Quek Bin Huey , Singh Neetu , Zenge Jeanne P. , Shults Justine , Nishisaki Akira ,   for the National Emergency Airway Registry for Neonates (NEAR4NEOS) Investigators
Published: July 2019

Objective This study aimed to examine the association between team stress level and adverse tracheal intubation (TI)-associated events during neonatal intubations.
Study Design TIs from 10 academic neonatal intensive care units were analyzed. Team stress level was rated immediately after TI using a 7-point Likert scale (1 = high stress). Associations among team stress, adverse TI-associated events, and TI characteristics were evaluated.
Result In this study, 208 of 2,009 TIs (10%) had high stress levels (score < 4). Oxygenation failure, hemodynamic instability, and family presence were associated with high stress level. Video laryngoscopy and premedication were associated with lower stress levels. High stress level TIs were associated with adverse TI-associated event rates (31 vs. 16%, p < 0.001), which remained significant after adjusting for potential confounders including patient, provider, and practice factors associated with high stress (odds ratio: 1.90, 96% confidence interval: 1.36–2.67, p < 0.001).
Conclusion High team stress levels during TI were more frequently reported among TIs with adverse events.
Methods of Glycemic Control and Neonatal Outcomes after Antenatal Corticosteroid Administration among Women with Pregestational Diabetes
Authors: Battarbee Ashley N. , Anderson Sarah B. , Tita Alan T.N. , Harper Lorie M. 
Published: July 2019

AbstractObjective The objective of this study was to evaluate the association between the method of maternal glycemic control after antenatal corticosteroid, administration and maternal hyperglycemia and neonatal morbidity among women with diabetes.Study Design This was a retrospective cohort study of women with pregestational diabetes who received antenatal corticosteroids and delivered in <34 weeks. The primary maternal outcome was adequate glycemic control, defined as <50% of glucose values above goal (fasting <100 mg/dL, 2-hour postprandial <120 mg/dL, or <115 mg/dL on insulin infusion). The primary neonatal outcome was composite morbidity (continuous positive airway pressure, mechanical ventilation, intraventricular hemorrhage, or death). Demographic characteristics and outcomes were compared by the method of glycemic control and neonatal morbidity using chi-square test, Fisher's exact test, Mann–Whitney U-test, and Student's t-test, as appropriate.Results Of 52 eligible women, only 1 (1.9%) had adequate maternal glycemic control. There was no significant association between the method of glycemic control and maternal hyperglycemia or neonatal morbidity. There was no association between maternal glucose and neonatal morbidity; however, neonates with composite morbidity were more likely to be born to women who received less insulin.Conclusion Maternal glycemic control among women with diabetes was poor after the antenatal corticosteroid administration, regardless of glycemic control method. Neither the method of maternal glycemic control nor the degree of control was associated with neonatal morbidity.