bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Faktor Risiko dengan Kejadian Hipertensi di Wilayah Kerja Puskesmas Takalala Kecamatan Marioriwawo Kabupaten Soppeng
Authors: Musfirah Musfirah , Masriadi Masriadi 
Published: September 2019

Hipertensi atau tekanan darah tinggi merupakan kondisi ketika seseorang mengalami kenaikan tekanan darah baik secara lambat atau mendadak. Menurut WHO penyakit tidak menulartelah menjadi penyebab kematian terbesardi dunia. disebutkan bahwa hampir 17 jutaorang meninggal lebih awal tiap tahunnyasebagai akibat epidemik penyakit tidak menular. Pada tahun 2025 nanti, angka ini kemungkinan akan meningkat menjadi 29,2%. Dari 972 juta penderita hipertensi, 639 juta berada di negara sedang berkembang, termasuk Indonesia dan 333 sisanya berada di negara majuJenis penelitian ini adalah jenis penelitian observasional dengan rancangan Case Control Study (studi kasus kontrol). Penelitian ini dilakukan di wilayah kerja Puskesmas Takalala Kabupaten Soppeng tahun 2018. Besar sampel yang digunakan dalam penelitian ini, kasus sebanyak 68 responden dan kontrol sebanyak 68 responden dengan menggunakan Case Control. Analisis data yang digunakan univariat, dan bivariat.Kesimpulan dari hasil penelitian ini yaitu riwayat keluarga 5,5 kali lebih besar berisiko Hipertensi di wilayah kerja Puskesmas Takalala Kabupaten Soppeng.Saran dari hasil penelitian ini yaitu masyarakat harus menerapkan pola hidup sehat, olahraga teratur minimal tiga kali minggu selama 30 menit setiap sesinya, tidak merokok atau minum alkohol, menghindari makanan tinggi garam dan lemak, tidur cukup minimal 7 sampai 8 jam dalam hari, dan menghindari stres.
Comparison of Propranolol and Amitriptyline as Monotherapy for Migraine Prophylaxis
Authors: Islam Mohammad Ariful , Sultana Dahlia , Shahi Mohammad Selim , Hassan Mohammad Sayeed 
Published: September 2019

Background: Several drugs are used individually for migraine prophylaxis.
Objective: The purpose of the present study was to compare the propranolol and amitriptyline as monotherapy for the prophylaxis of migraine.
Methodology: This randomized control trial was conducted in headache clinic at Banghabandhu Sheikh Medical University (BSMMU), Dhaka, Bangladesh from July 2012 to June 2014 for a period of two (02) years. Migraine patients with or without aura of 16 to 50 years of age, patients not on any prophylactic medication were included for this study. Patients meeting all the criteria was randomized group A who were treated with Amitriptyline and group B who were treated with propranolol. Patients was followed for a three months period during which they was instructed to maintain a headache diary. The primary outcome evaluated was the proportion of patients in each group that achieved a 50% reduction in the number of days with headache.
Result: A total 80 adult patients were selected. During 1st visit among the patients duration of pain 1 to 4 hours (2.5.0%), 5 to 8 hours (13.3%) 9 to 12 hours (35.0%) and above 13 hours (22.5%) in group A were recorded; however, in group B, duration of pain 1 to 4 hours 1(2.5), 5-8 hours 16(13.3%), 9-12 hours 19(47.5) and above 13 hours 4(10.0) (p>0.05). In group A, no adverse effect was found 26(65.0%), drowsiness 6 (15.0%), dryness of mouth 6(15.0%), constipation 2(5.0%), fatigue and bradycardia were not found. In group B, no adverse effect was found 29(72.5%), drowsiness, dryness of mouth and constipation were not found, fatigue and bradycardia were 7(17.5%) and 4(10.0%).
Conclusion: In conclusion number of attack and headache before treatment gradually decrease in subsequent follow up in both groups.
Journal of Current and Advance Medical Research 2019;6(2):77-82
Relationship of Haemoglobin and C Reactive Protein level with Different Types of Heart Failure Patients
Authors: Morshed Mahboob , Islam Md Joynul , Haseen Fariha , Haque Mohammad Ahtashamul , Amin ABM Ruhul 
Published: September 2019

Background: Initial level of haemoglobin and CRP level is important issue among the different type of heart failure patients for their in-hospital outcomes.
Objective: The purpose of the present study was to see the relationship of haemoglobin (Hb) and CRP level with different types of heart failure patients.
Methodology: This cross-sectional study was conducted in the Department of Cardiology at Mymensingh Medical College, Mymensingh, Bangladesh from December 2010 to November 2011 for a period of two (2) years. Patients of ACS who were presented within 12 hours of chest pain were included as study population. Study population were categorized in four groups according to the level of hemoglobin and C-reactive protein. Blood sample was collected for baseline laboratory investigations like Troponin-I, random blood sugar (RBS), blood urea, serum creatinine, lipid profile, Hemoglobin and CRP level. Sample were then send to standard laboratory/Biochemistry department of MMCH.
Result: The mean age of the population was 52.18±8.88 years. Statistically non-significant mean age difference among the groups. Significant difference of mean left ventricular (LV) ejection fraction was found among the groups (p=0.005). Maximum patient in group 1 (48.5%) had ejection fraction in the range of 40 to 50%, compare to group 2(32.0%), group 3 (11.1%) and group 4 (5.8%). The heart failure was statistically significant in Killip class I (p=0.000) and Killip class II (p=0.000).
Conclusion: In conclusion haemoglobin and CRP level of acute coronary syndrome patients is statistically significantly associated with different types of heart failure
Journal of Current and Advance Medical Research 2019;6(2):101-105
A Comparative Parallel Study of Pharmacokinetics and Immunogenicity Following Single Intravenous Administration of Bevacizumab Biosimilar RPH-001 (Manufactured by R-Pharm Group, Russia) and Avastin® (Manufactured by F. Hoffmann-La Roche Ltd., Switzerland) in Healthy Male Volunteers
Authors: Kolganova M. A. , Bagaeva N. S. , Medvedev YuV. , Shohin I. E. , Demchinskaya A. V. , Palkina T. N. , Salazanov D. A. , Konopleva G. E. , Sheremeteva M. S. , Archuadze Sh. Z. , Lavrovsky Ya. V. , Savchenko A. Yu. , Samsonov M. Yu. 
Published: September 2019

Introduction. Bevacizumab is a monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). Bevacizumab is used as a targeted mono- or combination therapy for different solid tumors. Phase I clinical trial was performed to assess pharmacokinetics (PK) and immunogenicity of bevacizumab drugs. For this study 80 healthy male volunteers were recruited and randomized to either Avastin or RPH-001 group.Aim. To assess and compare pharmacokinetics and immunogenicity (safety) following single intravenous administration of Avastin® (manufactured by F. Hoffmann-La Roche Ltd.,Switzerland) and bevacizumab biosimilar RPH-001 (manufactured by R-Pharm Group,Russia).Materials and methods. Bevacizumab quantitation and quasi-quantitative anti-bevacizumab antibodies detection in human blood serum were carried out using photometric ELISA. Two different methods were successfully validated.Results and discussion. Bevacizumab quantitation method was validated for selectivity and specificity, calibration curve, sensitivity, accuracy and precision, minimal required dilution, dilution linearity and stability. The anti-bevacizumab antibodies detection method was validated for cut-point (with normalization factor calculation), selectivity, sensitivity, precision, drug tolerance, dilution linearity, matrix effect (in case of serum hemolysis), and stability. The validated methods were successfully applied to pharmacokinetic and immunogenicity assessment of bevacizumab drugs. Conclusion. The results of the PK-study showed that test and reference bevacizumab drugs were equivalent. Immunogenicity study did not show any evidence of anti-bevacizumab antibodies in blood serum samples.
Study of Lercanidipine Drug Release from Medicine in Combination with Ramipril <i>in vitro</i> and <i>in vivo
Authors: Shadrin A. A. , Ivkin D. Y. , Flisyuk E. V. , Smekhova I. E. , Plisko G. A. , Karpov A. A. , Semivelichenko E. D. 
Published: September 2019

Introduction. Hypertension is the most common non-infectious disease in the world. New clinical recommendations for the diagnosis and management of patients with arterial hypertension are considering the issue of prescribing combination therapy and prefer fixed combinations of drugs in a single pill. The study of the pharmacokinetics of medicinal substances and the consideration of their pharmacokinetic parameters today is a necessary step in the complex of work, both in the creation of new original medicines and in the application of known generic drugs, and this is primarily due to obtaining objective characteristics of all processes occur in the body of the animal (human) with the drug. Pharmacokinetics is assessed in individual studies or as part of efficacy, safety, and tolerability studies.Aim. The study of the release of lercanidipine from bilayer tablets containing two API (ramipril and lercanidipine) in the dissolution medium used for quality control in vitro and release in vivo, after oral administration of the drug to rabbits.Materials and methods. Studies have been conducted on the release of lercanidipine from the combined drug in vitro and in vivo. As a test system were used laboratory rabbits Soviet chinchilla breed. Pharmacokinetic parameters were determined.Results and discussion. A graph of the release of lercanidipine from the combined drug was constructed and the dependence of the concentration of this substance in the blood plasma of rabbits on time was revealed. Calculated pharmacokinetic parameters. An in vivo release study shows that the pharmacokinetics of lercanidipine are consistent with literature data.Conclusion. The test drug has all the advantages of a rational fixed combination of antihypertensive drugs and simplifies therapy, meets the requirements of the latest clinical guidelines.
Actual Aspects of Medical Application of Black Nut – Juglans Nigra L. (Review)
Authors: Korochinsky A. V. , Daironas Ja. V. , Vernikovsky V. V. , Zilfikarov I. N. , Stepanova E. F. , Chernikov M. V. 
Published: September 2019

Introduction. Herbal drugs of black walnut (Juglans nigra L.) are not registered on the territory of the Russian Federation at the present time. However, the State Register of Medicinal Products includes an extract of unripe fruits of a related species walnut (Juglans regia L.) «Yuglanex» (made in Russia) and the complex herbal drug «Tonsilgon» (made in Germany). A number of biologically active food supplements from black walnut raw materials have been registered by Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. They are an additional source of phenolic compounds as tannins and flavonoids. The purpose of the article is to study and systematize up-to-date information on the chemical composition of the medicinal plant raw material of black walnut and the pharmacological properties of its main biologically active compounds.Text. All parts of the black walnut are used in the ethnomedicine of the indigenous population of North America according to indications similar to the walnut in Asia and the Manchurian nut in the Far East: snake bites, fever and disorders of the gastrointestinal tract.The chemical composition of the medicinal plant raw material of black walnut is dencently walnut by its qualitative composition. Fruits, bark and leaves of black walnut contain a rich polyphenol complex (naphthoquinones, in particular, juglon and its derivatives, tannins, flavonoids, phenolic acids), vitamins, essential oil, organic acids. However, the quantitative analysis revealed a higher content of biologically active substances in the raw black walnut, especially in relation to polyphenolic compounds.The scientific literature describes the results of experiments on animals, confirming antioxidant, antimicrobial, antifungal, antiviral, antiparasitic, hypoglycemic, antispasmodic, and anti-tumor effect on certain cell lines.Conclusion. As a result of studying the literature and systematizing the current information on the chemical composition of the medicinal plant raw material of the black nut and the pharmacological properties of its main biologically active compounds, it has been established that the main properties are related to the presence of the phenol complex. However, a deeper study of the chemical composition is required. Both the total extracts of the black walnut from plant raw materials and individual compounds show predominantly antimicrobial, antifungal, antioxidant, antiviral, hypotensive, immunomodulatory, antitumor and antispasmodic activities in preclinical trials.
Evaluation of Pharmacokinetical Parameters of Phenol, a Component of Antiseptic Dorogov's stimulator 3 Fraction Paste
Authors: Nozdrin V. I. , Piavchenko G. A. , Ivanova M. E. , Guzev K. S. , Kuznetsov S. L. 
Published: September 2019

Introduction. Antiseptic Dorogov's stimulator 3rd fraction (ASD-3) is a multicomponent substance, which is obtained by the thermal processing of cattle-origin tissues, which contains more than 120 substances, including biologically active substances. Among the components of ASD-3, necessary for quantitative analysis, pyrrole, phenol, cresol and its derivatives, and indole are distinguished as components. Despite the fact that antiseptic Dorogov's stimulator 3rd fraction was discovered more than half a century ago, there is no information about the pharmacokinetics of the drug components to date. Phenol is one of the preferred substances for research because that is a substance applied in the pharmaceutical technology for the manufacture of medicines.Aim. Study of pharmacokinetic parameters of phenol as a component of a drug containing an antiseptic Dorogov's stimulator 3rd fraction in a dose of 0.5 g/kg, with a single use in a blood serum of 84 female rats weighing 100–120 g.Materials and methods. In the blood serum of the 84 female Wistar rats weighing 100–120 g a study of a phenol pharmacokinetics as a component of ASD-3 drug in a dose of 0.5 g/kg was performed by a single skin application. The first group of animals was intraperitoneally injected with an aqueous emulsion containing 5% ASD-3, while the second one received zinc paste containing 5% ASD-3 on a skin surface. After the application of the emulsion or paste, the animals were euthanized after 0.25; 0.5; 1; 1.5; 2; 6 and 8 hours with further collection of blood from the abdominal aorta into centrifuge tubes. The study was carried out by high performance liquid chromatography.Results and discussion. The elimination rate constant for intraperitoneal drug emulsion injection is 0,0968 h-1, and when the drug paste is applied, 0.0581 h-1. As a result, the half-life of phenol in the first case is 7.2 hours, and in the second case – 11.9 hours. The relative bioavailability of the phenol from the paste containing 5% of the ASD-3 is 14.38% to the 5% emulsion injected into the rats body intraperitoneally.Conclusion. Comparison of the phenol concentration in the blood serum of experimental animals in two ways of application showed that the skin application of a drug paste containing 5% of ASD-3 provides a 10 times lower content of phenol in the blood serum compared to the intraperitoneal application of an emulsion with 5% ASD-3. 15 minutes after the skin application, the components of the drug start to be detected in the blood serum, reaching its maximum concentration in 1.5–2 hours, subsequently gradually decreasing.
Influence of the Method of Treatment of Samples of Biological Nature on the Results of Determination of Heavy Metals by Atomic Emission Spectroscopy
Authors: Blokhina E. N. , Kelus N. V. , Chuchalin V. S. 
Published: September 2019

Introduction. The article is devoted to the relevance of choosing sample preparation method for heavy metals concentration determination in biological sample by using atomic emission spectrometry. Much attention is given to compare 2 methods of sample preparation: solid-phase extraction and microwave decomposition. As the result of analysis of heavy metals Fe, Zn, Rb, Cu, Ni, Al, Mn content using these sample preparation methods the following conclusions are drawn: maximum extraction of heavy metals is achieved by using microwave decomposition method.Aim. The purpose of this work was to compare the methods and conditions for the sample preparation of biological samples for the determination of the content of heavy metals using atomic emission spectrometry.Materials and methods. The object of the study to determine the content of heavy metals (Zn, Rb, Cu, Ni, Al, Mn) was the liver of golden hamsters of both sexes weighing 60–145 g of the type Golden Syrian SPF category, obtained from the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (Novosibirsk). Quantitative determination of heavy metals in biological samples was carried out on an Agilent 4100 atomic emission spectrometer with a microwave plasma (Agilent Technologies, USA).Results and discussion. Comparison of the content of elements in the sample using the sample preparations under study showed that the maximum extraction of heavy metals from biological samples is achieved when using the method of microwave decomposition. The most complete extraction of heavy metals from biological samples is achieved by extraction within 30 minutes.Conclusion. This method warrants the maximum metal extraction, is more accurate, rapid and less labor intensive compared to other methods considered, and is suitable for determining most heavy metals.
DETERMINAN KEBIJAKAN DIVIDEN PADA PERUSAHAAN TELEKOMUNIKASI DI INDONESIA
Authors: Ismawati Linna 
Published: September 2019

Abstract. The purpose of this research is to identify the determinants of corporate dividend policy At The Telecommuniactions in Indonesian. The Study uses a firm-level panel data set of four publicly traded the telecommunications on Indonesian Stock Exchange between 2010-2015. The Study develops four research hypotheses, which are used to represent the main theories of corporate dividends. The design of analysis used is multiple regression analysis, correlation coefficient analysis, and coefficient of determination analysis, while hypothesis testing using T test and F test. The Result in partial effect Return On Equity gives significantly positive effect on Dividend Payout Ratio (DPR), while Current Ratio and Debt To Equity Ratio are not significant effect on Dividend Payout Ratio. In simultaneously Effect Return On Equity, Current Ratio, Debt To Equity Ratio have effect to Dividend Payout Ratio.Keywords. current ratio; debt to equity ratio; dividend payout ratio; return on equity. Abstrak. Penelitian ini bertujuan untuk mengidentifikasi determinan kebijakan dividen pada perusahaan telekomunikasi di Indonesia. Penelitian menggunakan data panel empat perusahaan telekomunikasi yang terdaftar di Bursa Efek Indonesia tahun 2010-2015. Dalam penelitian ini disusun empat hipotesis penelitian, yang digunakan untuk mewakili teori utama kebijakan dividen. Rancangan analisis yang digunakan adalah analisis regresi berganda, analisis koefisien korelasi, dan analisis koefisien determinasi, sedangkan pengujian hipotesis menggunakan uji T dan uji F. Hasil penelitian menunjukkan bahwa secara parsial tingkat pengembalian modal berpengaruh terhadap kebijakan dividen, tetapi rasio lancar dan rasio hutang tidak berpengaruh signifikan terhadap kebijakan dividen. Secara simultan tingkat pengembalian modal, rasio lancar, dan rasio hutang berpengaruh terhadap kebijakan dividen.Katakunci. rasio hutang; rasio lancar; rasio pembayaran dividen; tingkat pengembalian modal.
ANALISIS PERBANDINGAN KINERJA KEUANGAN PERUSAHAAN FARMASI MILIK BUMN DAN SWASTA
Authors: Mardiyani Mardiyani 
Published: September 2019

Abstract. This research as a purpose to comparative analysis of financial performance in the pharmacy state owned corporation with private corporation listed in Indonesian Stock Exchange during 2010-2014 periods. The methodologies of Reseach is descriptive compatative, sampling used was 8 companies listed in ISE for 5 periods. Analysis technique used was Independen sample T-test. The Result of analysis show that comparative of financial performance in the pharmacy state owned corporation with private corporation base on ROE is be found significantly differentiation because the private corporation ROE is safe position on 15%, where as state owned corporation ROE is under safe position. If looked base on EPS is be found significantly differentiation between pharmacy state owned corporation with private corporation because private corporate EPS better than state owned corporate. For EVA value the pharmacy state owned corporation with private corporation not be found significantly differentiation because the second corporate have EVA negative.Keywords. financial performance; ROE; EPS; EVA Abstrak. Penelitian ini bertujuan untuk menganalisis perbandingan kinerja keuangan perusahaan farmasi milik BUMN dan Swasta yang terdaftar di Bursa Efek Indonesia dari tahun 2010 – 2014. Metode penelitian yang digunakan deskriptif komparatif, dengan sampel 8 perusahaan farmasi yang terdaftar di BEI selama 5 tahun. Sementara teknik pengolahan data menggunakan Independen sample T-test. Hasil penelitian menunjukkan bahwa Perbandingan kinerja keuangan perusahaan farmasi milik BUMN dan Swasta berdasarkan ROE terdapat perbedaan yang signifikan karena ROE milik swasta ada di posisi aman dengan persentase diatas 15%, sementara persentase ROE perusahaan farmasi BUMN masih dibawah posisi aman. Apabila dilihat berdasarkan EPS terdapat perbedaan signifikan antara EPS perusahaan farmasi milik BUMN dan swasta karena laba per lembar saham milik perusahaan farmasi Swasta rata-ratanya jauh lebih tinggi dari perusahaan BUMN. Namun untuk nilai EVA perusahaan farmasi BUMN dan swasta tidak terdapat perbedaan yang signifikan karena kedua jenis perusahaan ini sama-sama memiliki nilai EVA negatif.Katakunci. kinerja keuangan; ROE; EPS; EVA