bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introducing nurse‐led heart failure clinics in Swedish primary care settings
Authors: Liljeroos Maria , Strömberg Anna 
Published: October 2018

AimAccording to clinical guidelines, it is recommended that patients with heart failure (HF) receive structured multidisciplinary care at nurse‐led HF clinics in order to optimise treatment and avoid preventable readmissions. Today, there are HF clinics with specialist‐trained nurses at almost all Swedish hospitals, but HF clinics remain scarce in primary care (PC). The aim of this study was two‐fold: firstly, to evaluate the effects of systematically implementing nurse‐led HF clinics in PC settings with regard to hospital healthcare utilisation and evidence‐based HF treatment, and secondly to explore patients' experiences of HF clinics in PC.Methods and resultsThe study had a pre‐post design. Annual measurement were done between 2010–2017 regarding in‐hospital healthcare consumption and medical treatment. Data from 2011–2017 after the implementation of HF clinics in PC in one county council Sweden were compared with baseline data collected before the implementation in 2010. The implementation of HF clinics in PC significantly reduced the number of HF‐related hospital admissions by 27% (P < 0.001), HF hospital days by 27.3% (P < 0.001) and HF emergency room visits by 24% (P < 0.001). Further, patients were to a higher extent medically treated according to guidelines and satisfied with the care they received at the PC HF clinic.ConclusionNurse‐led HF clinics in PC seem to be effective in reducing the need for in‐hospital care and provide high quality person‐centred care.
Time‐domain electromagnetic imaging of a clayey confining bed in a brackish environment: A case study in the Kairouan Plain Aquifer (Kelbia salt lake, Tunisia)
Authors: Finco Cécile , Pontoreau Coralie , Schamper Cyril , Massuel Sylvain , Hovhannissian Gaghik , Rejiba Fayçal 
Published: October 2018

AbstractThe semi‐arid Plio‐Quaternary aquifer of the Kairouan Plain is located in the central part of Tunisia. In this region, the main form of human activity is extensive agriculture. The few lithological logs in this area indicate that the aquifer is divided into two groundwater reservoirs separated by a confining clay layer. In the shallower groundwater reservoir, the electrical conductivity of the water is close to 1,200 mS/m, that is, 3 to 4 times higher than that of the deeper aquifer, which is currently used for irrigation. Recently, an increase in salinity has been observed, which is producing significant difficulties with irrigation. In order to determine the geometry of the confining clay layer and assess the potential connectivity between both reservoirs, time‐domain electromagnetic (TDEM) and vertical electrical soundings surveys were carried out. In the extremely conductive environment (electrical resistivities <10 Ωm) of the Sebkha Kelbia, the TDEM survey produced the first geophysical map of this near‐surface aquifer system.
Assessing sustainability of agricultural water saving in an arid area with shallow groundwater
Authors: Xue Jingyuan , Huo Zailin , Huang Quanzhong , Wang Fengxin , Boll Jan , Huang Guanhua , Qu Zhongyi 
Published: October 2018

AbstractAgricultural water‐saving practices are important in order to cope with the increasing shortage of water resources in arid and semi‐arid areas. With water use efficiency and productivity being improved, however, more intense regional agricultural water‐saving practices may induce the reduction of vegetation coverage and also groundwater decline. We assess the sustainability of regional agricultural water‐saving practices in an arid area based on the analytic hierarchy process (APH). By calculating water use efficiency, economic benefit, social benefit and eco‐environmental effect, the sustainability of regional agricultural water savings can be comprehensively evaluated and classified using different sustainability evaluation scoring standards. As a case study, the method was used in the Jiefangzha irrigation district (JFID), and the sustainability of agricultural water saving was assessed from 1990 to 2009. The results indicate that economic benefit and social water‐saving awareness have increased dramatically since 1998. Water use efficiency and productivity have increased continuously, while the declining groundwater has had negative effects on vegetation coverage. Since 1998, the sustainability state shows an increasing trend with its all values above the alert line (0.4), and most of the sustainability values above the good line (0.6), which reveals a good condition of the sustainability of agricultural water savings in the JFID. © 2018 John Wiley & Sons, Ltd.
Long noncoding RNA HOTAIR silencing inhibits invasion and proliferation of human colon cancer LoVo cells via regulating IGF2BP2
Authors: Wu Xue‐Liang , Lu Rui‐Yun , Wang Li‐Kun , Wang Yuan‐Yuan , Dai Yong‐Jun , Wang Chen‐Yu , Yang Yong‐Jiang , Guo Fei , Xue Jun , Yang Dong‐Dong 
Published: October 2018

AbstractColon cancer is one of the most life‐threatening malignancies worldwide. Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) is a cancer‐associated biomarker involved in the metastasis and prognosis of several cancers. However, whether and how HOTAIR affects colon cancer progression is still unclear. Consequently, we used RNA interference to knock down HOTAIR to explore its effects on human colon cancer cells. The dual luciferase reporter gene assay was initially used for testify the regulating relationship between lncRNA HOTAIR and insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2). We determined the expressions of HOTAIR, IGF2BP2, E‐cadherin, and vimentin. Meanwhile, cell growth, cycle and apoptosis, migration, and invasion were assayed. LoVo cells were transplanted into nude mice, and tumor formation and microvessel density were evaluated. LncRNA HOTAIR positively regulated IGF2BP2. Besides, the expressions of HOTAIR and E‐cadherin and the apoptosis were increased, while the expressions of IGF2BP2 and vimentin, the growth, invasion and migration of LoVo cells, the average tumor weight, and microvessel density value were decreased. Of importance, overexpressed IGF2BP2 could reverse the above impacts. Taken together, the current study indicates that silencing of HOTAIR could inhibit the invasion, proliferation, and migration, and promote apoptosis of colon cancer LoVo cells through suppressing IGF2BP2 and the epithelial‐mesenchymal transition.
Low expression of NCOA5 predicts poor prognosis in human cervical cancer and promotes proliferation, migration, and invasion of cervical cancer cell lines by regulating notch3 signaling pathway
Authors: Liang Ying , Zhang Tianli , Shi Mengdie , Zhang Shuo , Guo Yaxing , Gao Jiwei , Yang Xingsheng 
Published: October 2018

AbstractNuclear receptor coactivator 5 (NCOA5) specifically enhances estrogen receptor α–modulated transcriptional activity. As a novel tumor suppressor, depletion of NCOA5 is associated with the development of a variety of tumors, but its function in cervical cancer is currently unclear. In this study, we addressed how expression of NCOA5 changed in the development of human cervical cancer and its association with clinicopathological features, prognosis, and biology characteristics of cervical cancer. Analysis of the microarrays in the Oncomine database indicated that NCOA5 expression was lower in human cervical squamous cell carcinoma tissues than that in normal cervical tissues. That was corroborated by our experiments using fresh tissues: the expression levels of NCOA5 messenger RNA and protein were both significantly decreased in cervical cancer tissues compared with paired adjacent nontumor tissues (P < 0.01). Low expression of NCOA5 is associated with the International Federation of Gynecology and Obstetrics stage (
P = 0.043) and histological grade (
P = 0.018) of human cervical cancer. In addition, patients possessing low NCOA5 expression had poorer prognosis. Univariate and multivariate Cox regression analyses indicated that low NCOA5 expression may be an independent prognostic factor for poorer overall survival in cervical cancer. Further, downregulation of NCOA5 expression results in a significant increase in proliferation, migration, and invasion of HeLa cells. Data of xenograft tumor on BALB/c nude mice manifested that HeLa cells with low NCOA5 expression tend to form larger tumors than negative control ones. In contrast, overexpression of NCOA5 expression leads to the opposite results. Finally, we found that NCOA5 might affect the biological function of human cervical cancer cells by mediating the notch3 signaling pathway. These findings suggest that NCOA5 acts as a tumor suppressor to inhibit tumorigenicity, migration, and invasion, and thus represents a potential novel prognostic marker for overall survival in cervical cancer.
Influenza A virus neuraminidase protein interacts with Hsp90, to stabilize itself and enhance cell survival
Authors: Kumar Purnima , Gaur Pratibha , Kumari Rashmi , Lal Sunil K 
Published: October 2018

AbstractNeuraminidase protein (NA) of influenza A virus (IAV) is popularly known for its sialidase function to assist in the release of progeny virus. However, involvement of NA in other stages of the IAV life cycle also indicates its multifunctional nature and necessity to interact with other host proteins. Here, we report a host protein—heat shock protein 90 (Hsp90), as a novel interacting partner of IAV NA. A classical yeast two‐hybrid screen was conducted to identify a new host interacting partner for NA and the interaction was further validated by coimmunoprecipitation from cells, transiently expressing both proteins and also from IAV‐infected cells. Confocal imaging showed that both proteins colocalized in the cytoplasm in transfected host cells. Interestingly, increased levels of NA in the presence of Hsp90 was observed, which tends to decrease if adenosine triphosphatase activity of Hsp90 is inhibited using 17‐N‐allylamino‐17‐demethoxygeldanamycin (17AAG). This establishes viral NA as a client protein of host chaperone Hsp90 contributing toward NA's stability via the NA‐Hsp90 interaction. This is the first report showing the interaction of NA with Hsp90 and its role in stabilizing viral NA thus preventing it from degradation. Enhanced cell survival in the presence of this interaction was also observed, thus suggesting the requirement of stable viral NA, post‐IAV infection, for efficient virus production in infected mammalian cells.
A new therapy for each patient: Evidence‐based relationships and responsiveness
Authors: Norcross John C. , Wampold Bruce E. 
Published: October 2018

AbstractIn this study, we introduce the journal issue devoted to evidence‐based responsiveness and frame it within the work of the third interdivisional APA Task Force on Evidence‐Based Relationships and Responsiveness. We summarize the meta‐analytic results and clinical practices on the adaptations of psychotherapy to multiple transdiagnostic characteristics of the patient, including attachment style, culture (race/ethnicity), gender identity, coping style, therapy preferences, reactance level, religion and spirituality, sexual orientation, and stages of change. We then discuss the clinical and research process of determining what works, and what does not work, for whom. The limitations of the Task Force’s work are outlined and frequently asked questions are addressed. The article closes with the Task Force’s formal conclusions and 28 recommendations and with some reflections on fitting psychotherapy to the individual client.
Combination therapy for the treatment of pancreatic cancer through hyaluronic acid‐decorated nanoparticles loaded with quercetin and gemcitabine: A preliminary in vitro study
Authors: Serri Carla , Quagliariello Vincenzo , Iaffaioli Rosario Vincenzo , Fusco Sabato , Botti Gerardo , Mayol Laura , Biondi Marco 
Published: October 2018

AbstractCombination chemotherapy by means of two or more drugs is prone to suppressing or discouraging the inception of multidrug resistance, exploiting the fact that diverse drugs act in different points of the cellular cycle of amplifying tumor cells. For example, the combination of gemcitabine (GMC) with quercetin (QCT) showed a synergistic effect in inhibiting the migration of pancreatic cancer cells. Consequently, herein GMC and QCT have been loaded within biodegradable nanoparticles (NPs) based on poly(lactic‐co‐glycolic acid), externally decorated with hyaluronic acid (HA; viz., PPHA NPs), which plays a major role in drug targeting to tumors due to its ability to specifically interact with CD44 receptor, that is overexpressed in many tumors. The produced HA‐decorated NPs loaded with GMC and QCT showed an improved cytotoxicity and cellular uptake toward two cell lines of pancreatic ductal adenocarcinoma, namely Mia‐PaCa‐2 and PANC‐1, compared with both the bare drugs and the drugs loaded in NPs which do not expose HA on the surface. HA‐decorated NPs were also able to improve the anti‐inflammatory properties of QCT, therefore leading to a decrease of interleukin cellular levels in both cell lines, preliminarily stimulated with lipopolysaccharides. This result is of special interest also considering the crucial role of interleukins in progression, metastatic processes, and drug resistance of human pancreas cancer cells.
Population Pharmacokinetics and Exposure — Safety Analyses of Nivolumab in Patients With Relapsed or Refractory Classical Hodgkin Lymphoma
Authors: Wang Xiaoli , Ludwig Elizabeth A. , Passarell Julie , Bello Akintunde , Roy Amit , Hruska Matthew W. 
Published: October 2018

AbstractNivolumab, a fully human immunoglobulin G4 monoclonal anti‐programmed death‐1 antibody, has demonstrated clinical benefits in multiple tumors, including classical Hodgkin lymphoma. The aim of this study was to characterize the pharmacokinetics (PK) of nivolumab in patients with classical Hodgkin lymphoma using a population approach and to assess the exposure‐response (E‐R) relationship for safety, thereby supporting the dose recommendation in patients with classical Hodgkin lymphoma. Nivolumab PK and the effect of covariates were consistent with that observed in solid tumors, except that baseline clearance of nivolumab was lower in patients with classical Hodgkin lymphoma by 28%. The E‐R analysis for safety, characterized by a Cox proportional hazards model, indicated that the resulting increased nivolumab exposure (average concentration after the first dose) was not a significant predictor of the risk of grade ≥3 drug‐related adverse events. Given the acceptable safety profile and observed benefit (65% objective response rate) with the nivolumab 3 mg/kg every 2 week dosing regimen for classical Hodgkin lymphoma, together with the flat E‐R safety relationship, nivolumab demonstrated a favorable benefit‐risk profile across the range of exposures of 3 mg/kg every 2 weeks in patients with classical Hodgkin lymphoma. Additional model‐based simulation suggested that a flat dose of 240 mg every 2 weeks was predicted to produce similar exposures to that of 3 mg/kg every 2 weeks. Therefore, nivolumab 240 mg every 2 weeks is the recommended dosing regimen in the classical Hodgkin lymphoma population.
Ginkgo biloba sarcotesta polysaccharide inhibits inflammatory responses through suppressing both NF‐κB and MAPK signaling pathway
Authors: Ye Jing , Ye Changqing , Huang Yayan , Zhang Na , Zhang Xueqin , Xiao Meitian 
Published: October 2018

AbstractBACKGROUNDPolysaccharides, common components of natural products extensively studied as dietary supplements and functional foods, have been found to have various activities. In the present study, a water‐soluble polysaccharide, namely GBSP3a, was isolated and purified from G. biloba sarcotesta. The anti‐inflammatory activity of GBSP3a in lipopolysaccharide (LPS)‐induced RAW264.7 macrophages and the potential underlying molecular mechanisms were then assessed.RESULTSGBSP3a exerted its anti‐inflammatory effect by remarkably inhibiting the secretion of pro‐inflammatory mediators and cytokines, including nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6) and interleukin‐1β (IL‐1β) in LPS‐stimulated RAW264.7 macrophages. Excessive mRNA and protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) were dose‐dependently inhibited by GBSP3a in LPS‐stimulated RAW264.7 cells. Further research suggested that the anti‐inflammatory effect of GBSP3a can be attributed to the modulation of the NF‐κB and MAPK signaling pathways.CONCLUSIONGBSP3a exhibits anti‐inflammatory activity and exerts its anti‐inflammatory effect probably through suppressing both NF‐κB and MAPK signaling pathway, indicating that GBSP3a could be used for the development of anti‐inflammatory agent or nutraceuticals. © 2018 Society of Chemical Industry
Influence of microbial and chemical contaminants on the yield and quality of ethanol from wheat grains
Authors: Bartkiene Elena , Juodeikiene Grazina , Zadeike Daiva , Baliukoniene Violeta , Bakutis Bronius , Cizeikiene Dalia 
Published: October 2018

AbstractBACKGROUNDHigher alcohols and esters have a negative impact on ethanol quality; therefore, to analyze the influence of mycotoxins and pesticides on higher alcohols and esters formation during ethanol production from contaminated cereal grains is of outstanding importance.RESULTSIn this study, the yield of ethanol and the composition of volatile by‐products (acetaldehyde, methyl acetate, ethyl acetate, methanol, propanol, isobutanol, amyl and isoamyl alcohols) after fermentation of wheat grains artificially contaminated with Fusarium sporotrichioides and pesticides (triasulfuron and sulfosulfuron) were analyzed. Wheat grains contamination with triasulfuron significantly reduced ethanol yield and increased isobutanol and ethyl acetate content. Moreover, wheat grains infection with F. sporotrichioides significantly increased methyl acetate, ethyl acetate, isobutanol, and amyl and isoamyl alcohols content. Significant differences between pesticides and wheat variety on volatile compounds formation in ethanol has been estimated.CONCLUSIONThe results showed that grains contaminated with F. sporotrichioides and pesticides significantly influenced the process of alcoholic fermentation that leads to variation of by‐products in ethanol, including higher alcohols, esters, and aldehydes. © 2018 Society of Chemical Industry
Differential expression analysis of meat tenderness governing genes in different skeletal muscles of bovines
Authors: Temizkan Mehmet C , Bayraktaroglu Alev G , Kahraman Tolga 
Published: October 2018

AbstractBACKGROUNDThe aim of this study was to compare 12 different skeletal muscles of bovine (n = 15) with each other in terms of tenderness and meat‐quality‐related gene expressions. Tenderness values were evaluated by shear force, and ANK1, CAPN1, CAST, HSPB1, HSPA1A gene expressions were analyzed by using quantitative real‐time polymerase chain reaction.RESULTSANK1 gene showed significant differences between tender and tough muscles (P < 0.001) and was found to be more closely related to meat quality than CAPN1. No difference was found for CAST, HSPB1, and HSPA1A gene expressions between different parts of skeletal muscles (P > 0.05). The results also showed that the most convenient skeletal muscle for the meat quality studies is musculus psoas major. Furthermore, comparative use of musculus longissimus thoracis and musculus extensor digitorum muscles may give the most accurate results, rather than using other muscle groups in comparative studies between tender and tough muscles.CONCLUSIONANK1 gene is a preferable biomarker for the determination of meat quality, and CAPN1 needs further studies. However, CAST, HSPB1, and HSPA1A genes may not be suitable biomarkers for the determination of meat quality based on this study. © 2018 Society of Chemical Industry
An Examination of the Role of Difficulties Regulating Positive Emotions in Posttraumatic Stress Disorder
Authors: Weiss Nicole H. , Dixon‐Gordon Katherine L. , Peasant Courtney , Sullivan Tami P. 
Published: October 2018

AbstractEmotion regulation difficulties have been theoretically and empirically linked to posttraumatic stress disorder (PTSD). Previous research, however, has focused almost exclusively on difficulties regulating negative emotions. In this study, we explored the nature of difficulties regulating positive emotions in PTSD. Participants were women who had experienced domestic violence (N = 210; 48.6% African American; Mage = 36.14 years). Higher levels of nonacceptance of positive emotions, difficulties engaging in goal‐directed behaviors when experiencing positive emotions, and difficulties controlling impulsive behaviors when experiencing positive emotions were related to a higher level of PTSD symptom severity overall and for the intrusion, avoidance/emotional numbing, and hyperarousal clusters, rs = .24–.37. The presence (vs. absence) of a probable PTSD diagnosis was related to greater difficulties engaging in goal‐directed behaviors, d = 0.54, and controlling impulsive behaviors, d = 0.34, when experiencing positive emotions. Results suggest the potential utility of assessing and treating difficulties regulating positive emotions among domestic violence–victimized women with PTSD.
Neurophysiological Correlates of Collective Trauma Recall in 2009 L'Aquila Earthquake Survivors
Authors: Massaro Giuseppe , Altavilla Daniela , Aceto Paola , Pellicano Gaia Romana , Lucarelli Giada , Luciani Massimiliano , Lai Carlo 
Published: October 2018

AbstractIn the present study, we aimed to explore neural correlates of survivors of the 2009 L'Aquila, Italy earthquake in response to being shown pictures featuring their own city before and after an earthquake as well as those of an unfamiliar city. Moreover, we explored the associations among psychological variables and brain responses to the pictures of L'Aquila after the earthquake. Our final sample (N = 30 adults) comprised 15 survivors (M age = 31.40 years, SD = 9.42) and 15 controls (M age = 30.53 years, SD = 10.01). Participants’ electroencephalographic (EEG) data were recorded during a visual task that included earthquake‐related stimuli. Participants were assessed for posttraumatic and dissociation symptoms and event‐related potential components, and low‐resolution electromagnetic tomography (sLORETA) were analyzed. Compared to the control group, source localization in survivors indicated a lower intensity of the amygdala, hippocampal, parahippocampal, and temporopolar areas in response to visual stimuli concerning the earthquake, p < .001 to p < .0001. Results indicated a reduced limbic activation in response to visual stimuli that evoked the recall of earthquake in survivors. This finding suggests that survivors likely adopted a distancing strategy toward stimuli that may have elicited an emotional activation related to collective trauma.