bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanopharmacology: in vitro techniques to advance drug discovery
Authors: Zielinski Jana L. , Lee Chiao Hwei , Gunatilaka Avanka , Gao Bryan , Stewart Alastair G. 
Published: December 2024

AbstractMechanopharmacology is an emerging interdisciplinary field that investigates drug action using biomechanically appropriate in vitro systems to the relevant (patho)physiology. This review outlines emerging technologies and techniques which aim to bridge the gap between mechanical cues influencing cellular biology and conventional pharmacology. We delve into the impact of mechanopharmacology on drug development in cancers and fibrotic diseases. Mechanical cues such as stretch, stiffness, circadian rhythms, fluid flow, intercellular signalling cascades and cytoskeletal structures can modulate drug interactions with molecular targets with implications for drug discovery and development. Models incorporating mechanopharmacological cues to investigate pharmacokinetics, pharmacodynamics and therapeutic outcomes are outlined. Furthermore, this review discusses innovations in the use of biomaterials and microfluidics to further enable the emulation of the mechanical microenvironment. We advocate for the application of mechanopharmacological considerations to improve the physiological relevance of methods used in the drug discovery pipeline.
Multi‐omics revealed that DCP1A and SPDL1 determine embryogenesis defects in postovulatory ageing oocytes
Authors: Kong Li , Gong Yutian , Wang Yongyong , Yuan Mengjiao , Liu Wenxiang , Zhou Heyang , Meng Xiangyue , Guo Xinru , Liu Yongbin , Zhou Yang , Zhang Teng 
Published: December 2024

AbstractGrowing evidence indicates that the deterioration of egg quality caused by postovulatory ageing significantly hampers embryonic development. However, the molecular mechanisms by which postovulatory ageing leads to a decline in oocyte quality have not been fully characterized. In this study, we observed an accelerated decay of maternal mRNAs through RNA‐seq analyses in postovulatory‐aged (PostOA) oocytes. We noted that these downregulated mRNAs should be degraded during the 2‐cell stage. Proteomic analyses revealed that the degradation of maternal mRNAs is associated with the accumulation of DCP1A. The injection of exogenous Dcp1a mRNA or siRNA into MII stage oocytes proved that DCP1A could accelerate the degradation of maternal mRNAs. Additionally, we also found that SPDL1 is crucial for maintaining spindle/chromosome structure and chromosome euploidy in PostOA oocytes. Spdl1‐mRNA injection remarkably recovered the meiotic defects in PostOA oocytes. Collectively, our findings provide valuable insights into the molecular mechanisms underlying postovulatory ageing.
Effect of different sintering process on mechanical properties and microstructure of TiB2‐TiN‐based cermet material
Authors: Han Zhengyi , Xiao Guangchun , Chen Hui , Yi Mingdong , Zhang Jingjie , Chen Zhaoqiang , Xu Chonghai 
Published: December 2024

AbstractTiB2‐TiN‐NiTi cermet material was prepared by spark plasma sintering technology (SPS). The effects of the sintering process on their relative density, mechanical properties, and microstructure were studied with 74TiB2‐20TiN‐6NiTi as the composition system. The results showed that TiB2‐TiN‐based cermet material with the best mechanical properties was prepared under the sintering temperature of 1650°C and the holding time of 5 min. The relative density, flexural strength, fracture toughness, and hardness are 97.7%, 762.7 MPa, 5.5 MPa·m1/2, and 18.47 GPa, respectively. However, if the holding time keeps for 3 min under the sintering temperature of 900°C and then 5 min under the sintering temperature of 1650°C, the relative density, flexural strength, fracture toughness, and hardness of TiB2‐TiN‐based cermet reach 99.1%, 931.3 MPa, 5.8 MPa·m1/2, and 19.15 GPa, respectively. In comparison, they have been greatly improved by 1.4%, 22.1%, 5.5%, and 3.7%, respectively. The final holding time can also affect the mechanical properties of TiB2‐TiN‐based cermet material. When it is higher than 5 min, it will cause irregular growth and abnormal growth of grains, which can decrease the flexural strength of TiB2‐TiN‐based cermet material.
Face‐Looking as a Real‐Time Process in Mind‐Mindedness: Timely Coordination Between Mothers' Gaze on Infants' Faces and Mind‐Related Comments
Authors: Yamamoto Hiroki , Sunahara Nagomi , Kanakogi Yasuhiro 
Published: December 2024

ABSTRACTMaternal mind‐mindedness refers to a caregiver's tendency to respond to their infants as individuals with their own thoughts, feelings, desires, and beliefs. Although previous studies have focused on maternal speech in quantifying mind‐mindedness, maternal mind‐mindedness should manifest not only as mind‐related comments but also through non‐verbal behaviors during infant‐mother interactions. In this study, we investigated the relationship between maternal gaze at the infant's face and typical verbal measurement of mind‐mindedness in free‐flowing interactions. Forty 11‐ to 13‐month‐old infants and their mothers participated in the study; the mothers were asked to wear a head‐mounted eye tracker to measure their gaze during infant‐mother free‐play interactions. We measured the proportion of time mothers looked at the infant's face when it was present in the mother's field of view and examined the relationship between the face‐looking proportion and verbal measurement of mothers' mind‐mindedness. Mothers who displayed appropriate mind‐related comments looked at the faces of their infants more frequently. Moreover, their looking was coordinated in a timely manner with appropriate mind‐related comments compared with other comments. Our findings suggest that mothers looking at infants' faces supports comments regarding infants' mental states and shed new light on real‐time behaviors underlying mothers' mentalization processes.
Contribution of childhood lead exposure to psychopathology in the US population over the past 75 years
Authors: McFarland Michael J. , Reuben Aaron , Hauer Matt 
Published: December 2024

BackgroundMore than half of the current US population was exposed to adverse lead levels in childhood as a result of lead's past use in gasoline. The total contribution of childhood lead exposures to US‐population mental health and personality has yet to be evaluated.MethodsWe combined serial, cross‐sectional blood–lead level (BLL) data from National Health and Nutrition Examination Surveys (NHANES) with historic leaded‐gasoline data to estimate US childhood BLLs from 1940 to 2015 and calculate population mental‐health symptom elevations from known lead‐psychopathology associations. We utilized five outcomes: (1) General Psychopathology “points”, reflecting an individual's liability to overall mental disorder, scaled to match IQ scores (M = 100, SD = 15); (2) Symptoms of Internalizing disorders (anxiety and depression) and Attention‐deficit/Hyperactivity Disorder (AD/HD), both z‐scored (M = 0, SD = 1); and (3) Differences in the personality traits of Neuroticism and Conscientiousness (M = 0, SD = 1).ResultsAssuming that published lead‐psychopathology associations are causal and not purely correlational: We estimate that by 2015, the US population had gained 602‐million General Psychopathology factor points because of exposure arising from leaded gasoline, reflecting a 0.13‐standard‐deviation increase in overall liability to mental illness in the population and an estimated 151 million excess mental disorders attributable to lead exposure. Investigation of specific disorder‐domain symptoms identified a 0.64‐standard‐deviation increase in population‐level Internalizing symptoms and a 0.42‐standard‐deviation increase in AD/HD symptoms. Population‐level Neuroticism increased by 0.14 standard deviations and Conscientiousness decreased by 0.20 standard deviations. Lead‐associated mental health and personality differences were most pronounced for cohorts born from 1966 through 1986 (Generation X).ConclusionsA significant burden of mental illness symptomatology and disadvantageous personality differences can be attributed to US children's exposure to lead over the past 75 years. Lead's potential contribution to psychiatry, medicine, and children's health may be larger than previously assumed.
Regulatory Capital Management to Exceed Thresholds
Authors: OROZCO LUCIANA , RUBIO SILVINA 
Published: December 2024

AbstractWe investigate whether a carrot approach, which provides benefits for regulatory compliance rather than penalties for noncompliance, incentivizes banks to reach capital levels above the minimum requirements. We document a significant discontinuity at the 10% regulatory capital threshold, where banks receive benefits for exceeding it. Banks exceed it to pay lower deposit insurance fees, access brokered deposits, and expanded financial activities. Banks often rely on equity to reach this threshold while using accounting discretion primarily when facing small capital shortfalls. Our findings suggest the carrot approach can effectively increase banks' capital positions. However, we find that using accounting discretion to exceed the threshold hurts bank stability.
Mechanical properties of bone cells studied by atomic force microscopy
Authors: Zhang Xiaoqi , Wang Zuobin , Yu Haiyue , Tao Zengren , Ji Wei 
Published: December 2024

AbstractOsteoblasts are the functional cells capable of bone formation in the bone microenvironment and play an important role in bone growth, development, and the maintenance of bone mass. The cells cultured in vitro are derived from preosteoblasts in tissues and possess the ability to divide and proliferate. Osteoblasts form the bone matrix by secreting collagen and other matrix proteins, which provides a foundation for the deposition of minerals such as calcium and phosphorus, ultimately resulting in the formation of hard bone tissue. Bone diseases affect the quality of life and the aging of the population. Bone diseases such as osteoporosis, fractures, bone tumours, and arthritis have a significant impact on quality of life, especially among the elderly population. These realities remind us that we should pay more attention to bone and joint health. Therefore, it is particularly important to study the imaging and characterisation of mechanical properties of bone cells, which provides a basis for the research of bone diseases in human beings.
Perspectives of Patients Regarding Artificial Intelligence and Its Application in Healthcare: A Qualitative Study
Authors: Tursynbek Alma , Zhaksylykova Dilnaz , Cruz Jonas Preposi , Balay‐odao Ejercito Mangawa 
Published: December 2024

ABSTRACTBackgroundArtificial intelligence integration into healthcare has gained significant attention in recent years, with its use ranging from disease diagnosis to surgical assistance. While artificial intelligence's potential to improve patient outcomes and optimise patient care is undeniable, concerns regarding privacy, transparency, and the potential for medical errors persist. To take full advantage of artificial intelligence's transformative abilities, understanding patient perceptions and attitudes towards its integration into medicine is crucial for ethical considerations and health outcomes.PurposeThis study aimed to describe patients' perceptions of medical artificial intelligence and its integration into the healthcare system, drawing attention to a crucial yet understudied aspect of artificial intelligence adoption in Kazakhstan.DesignDescriptive qualitative design.MethodFrom February to March 2024, the researchers conducted semi‐structured interviews amongst 13 patients. The interviews were audio‐recorded, transcribed, translated, and then analysed using a thematic analysis approach. The study adhered to the COREQ guidelines.ResultFive themes emerged from 13 interviews: the benefits of artificial intelligence on patient care, the importance of human factors on patient care over artificial intelligence, revolutionising patient care delivery through artificial intelligence, patient education and artificial intelligence, and balancing technology and human interaction in artificial intelligence‐driven intervention.ConclusionPatient perceptions of artificial intelligence integration into healthcare were primarily positive. Nevertheless, patients prefer artificial intelligence as a supplementary tool under human supervision due to risks such as possible medical errors and violations of patient privacy.Patient or Public ContributionPatients provided the data for this study. The researchers interviewed them about their perceptions of medical artificial intelligence and its integration into the healthcare system. The patients or the public contributed nothing to the other aspects of the study.
Beyond larks and owls: Revisiting the circadian typology using the MESSi scale and a cluster‐based approach
Authors: Gorgol Joanna , Randler Christoph , Stolarski Maciej , Kalb Nadine 
Published: December 2024

SummaryChronopsychological research typically applied the morningness‐eveningness dimension, resulting in a distinction between morning, intermediate, and evening chronotypes. However, in recent years, new measures have been developed that transcend the traditional "morning larks" vs. "night owls" dichotomy and better capture the complexity of individual differences in circadian rhythmicity. One such measure that addresses the multidimensional character of the circadian rhythm is the Morningness‐Eveningness‐Stability Scale improved (MESSi) which comprises three dimensions: morning affect, eveningness, and distinctness. However, delineating specific chronotypes using the cut‐off points, as was commonly done for other established scales, is not possible in the case of MESSi due to its multidimensionality. In the present paper, we provide a first attempt to introduce a cluster‐based approach to deal with MESSi scores. For this purpose, we determined the number of clusters to be extracted using data from our previous study conducted in Poland (N = 1106). Next, we attempted to replicate this cluster solution in another Polish sample (N = 768) and a German sample (N = 637). Finally, we also intended to illustrate how individuals assigned to the established clusters differ in terms of sleep parameters and other differential variables such as positive and negative affect, personality traits, depressive and anxiety symptoms, self‐regulation, and self‐efficacy. After segmenting MESSi scores by cluster analysis in the three samples we found support for a four‐cluster solution, including four circadian profiles which we propose to label "intermediate‐finches", "hardy larks", "night owls", and "vulnerable larks". This is the first attempt to introduce a cluster‐based, multi‐dimensional approach to dealing with MESSi scores.
The type III effector RipBB from Ralstonia pseudosolanacearum inhibits plant immunity responses and contributes to virulence on peanut
Authors: Tan Xiaodan , Tang Huiquan , Huang Jinling , Dai Xiaoqiu , Chen Fang , Yu Junyi , Chen Jiajun , Yang Ruixue , Wan Xiaorong , Yang Yong 
Published: December 2024

AbstractRalstonia solanacearum species complex (RSSC) is a serious soilborne phytopathogen affecting over 310 plant species. R. pseudosolanacearum is one clade of RSSC, which infects the important oil crop peanut. A variety of virulence factors are employed by RSSC to promote disease, among which type III effectors (T3Es) are prominent. How T3Es manipulate the interaction between R. pseudosolanacearum and peanut is unclear. A T3E RipBB was previously found specifically in a more virulent peanut R. pseudosolanacearum PeaFJ1 strain. In the present study, the function of RipBB was analysed. Loss of RipBB from PeaFJ1 strain resulted in attenuated pathogenicity to peanut, and complementation with RipBB recovered the virulence of the mutant strain. Transient expression of RipBB induced cell death and inhibited flg22‐triggered reactive oxygen species (ROS) burst in the leaves of Nicotiana benthamiana. The expression of pattern‐triggered immunity (PTI)‐related genes were also suppressed by RipBB transient expression. Among the available sequenced 639 RSSC strains, RipBB is an infrequent T3E that is only present in eight strains. Two ankyrin (ANK) repeats were identified in RipBB, which play an important role in localizing the protein to the cytomembrane and nucleus. Altogether, we verified that RipBB contributes to infecting peanut by acting as a virulence T3E, and causes cell death and suppresses immunity in N. benthamiana. These results enhance the study of ANK‐containing effectors. Further elucidation of the molecular mechanisms underlying RipBB effect on immunity may reveal ANK‐containing effector functions in host cells, helping to understanding the mechanism of R. pseudosolanacearum–peanut interaction.
The Novel HLA‐DPB1*1327:01 Allele Identified by Next‐Generation Sequencing in a Potential Haematopoietic Stem Cell Donor
Authors: Zhao He , Webster Destinie , Pearce Twyla , Elemary Mohamed , Mostafa Ahmed 
Published: December 2024

ABSTRACTThe novel allele HLA‐DPB1*1327:01 has a non‐synonymous mutation difference compared with HLA‐DPB1*04:01:01.
Polymorphism in Pseudo‐Exon 5 Defines the Novel HLA‐DQB1*02:02:01:14 Allele
Authors: Zhao He , Webster Destinie , Pelzer Lindsay , Sabry Waleed , Mostafa Ahmed 
Published: December 2024

ABSTRACTThe novel allele HLA‐DQB1*02:02:01:14 differs from HLA‐DQB1*02:02:01:01 by one nucleotide substitution in codon 233 in exon 5.
Characterisation of Four Novel HLA Alleles: ‐A*02:01:222, ‐B*07:02:104, ‐C*07:02:156 and ‐DQB1*06:03:51
Authors: Ananeva Anastasiia , Akhmetshina Gulnaz , Aksenova Liliya , Shagimardanova Elena 
Published: December 2024

ABSTRACTFour novel HLA alleles HLA‐A*02:01:222, ‐B*07:02:104, ‐C*07:02:156 and ‐DQB1*06:03:51 alleles detected during routine next generation sequencing.
Green, Alternative or Business as Usual? Critical Geographies of Sustainable Finance
Authors: Dörry Sabine , Schulz Christian 
Published: December 2024

AbstractIn recent years, a growing number of contributions on green finance have emerged, not only within economic geography but also increasingly from disciplines beyond it. With this Special Issue, we aim to engage with the ongoing debate around green and sustainable finance and its challenges, including concerns over greenwashing. Our extended editorial provides structure to this complex discussion by identifying four primary strands of literature that frame the field. Two of these strands adopt a more critical stance, combining analytical approaches and rigorous assessments that question the impact and ‘authenticity’ of green and sustainable finance schemes, approaches and policies. Most of the contributions and empirical case studies featured here align with these critical perspectives, which are introduced in greater depth in the second part of this editorial.
THE POTENTIAL OF SLIMPAC AS A MANAGEMENT INFORMATION SYSTEM SOFTWARE - AN OVERVIEW
Authors: Mohd. Yunus Mohd. Zulkifli 
Published: December 2024

The selection of GIS software applications vary with the purposes and requirements ofusing it. The two major applications for GIS software are forÂ management/information and design analysis. The surveyors Land Information Management PACkage (SLIM) is basically developed for management or monitoring purposes and some design applications. Studies on areas of applications. specifications, operations. data sources. data organisations and information presentation shows the potentials of SLIMPAC as a Management Information System Package.
Strategi Pengembangan Pelancongan Islamik di Nusantara Melalui Model Homestay Patuh Syariah (MHPS) di Sabah / Strategies for the Development of Islamic Tourism in the Archipelago Through the Shariah Compliant Homestay Model (SCHM) in Sabah
Authors: Abdul Muin Suhailah , Abdullah Mohd Nor Azan , Rusdi Mikdar , M. Ag Mardyawati , Samuni Norcikeyonn 
Published: December 2024

The strategy of developing Islamic tourism in the archipelagos through the Shariah-Compliant Homestay Model in Sabah (MHPS) requires a holistic, structured approach. Key strategies include improving homestay infrastructure, providing courses for homestay owners on Sharia compliance, effective digital marketing, local community collaboration, religiously oriented tourism packages, and active involvement of religious institutions. The use of technology, efficient management, periodic evaluation, and developing local skills are crucial aspects of this Sharia-compliant homestay model. This approach aims to create a tourism experience that aligns with Sharia principles, positioning MHPS in Sabah as an attractive destination for Islamic tourists within the archipelago and globally. The success of this model depends on stakeholder cooperation and commitment to the continuity of Islamic tourism. The research method employed includes in-depth interviews with 30 homestay operators in Sabah, literature review, and field observation. The study shows that while Islamic tourism potential in Sabah and the archipelago is high, Sharia-compliant accommodation remains limited. Therefore, a comprehensive development strategy is essential to promote MHPS as a viable accommodation option for Muslim tourists. This strategy should involve government, entrepreneurs, and local communities, ensuring elements like cleanliness, gender separation, and halal food standards. Moreover, a strong marketing strategy emphasizing Islamic values and natural beauty preservation is necessary. The findings of this study are intended to guide relevant parties in maximizing Islamic tourism potential in Sabah and the archipelago, particularly in Malaysia, Indonesia, Brunei Darussalam, and other Asian countries. MHPS development is anticipated to increase the influx of Muslim tourists from Asia and beyond, generating economic benefits for local communities.
Severe septic cholangitis and pancreatitis withClostridium perfringens: a rare but fatal complication after ERCP
Authors: Cola Rahel Vera , Schreiber Peter , Schlag Christoph , Rogler Gerhard 
Published: December 2024

This case describes a patient treated with elective repeat endoscopic retrograde cholangiopancreatography (Re-ERCP). In the subsequent postinterventional course, the patient developed severe abdominal pain, followed by a rapid deterioration in the overall condition, resulting in circulatory instability. Despite the immediate initiation of antibiotic therapy, the patient’s general condition deteriorated progressively with persisting catecholamine dependency, escalating lactic acidosis and radiologic identification of air within the pancreas parenchyma and the splenic vein as well as along the surrounding tissues, leading ultimately to the patient’s death.Postmortem,Clostridium perfringenswas detected within the pancreatic parenchyma and blood cultures, establishing the diagnosis of post-ERCP pancreatitis complicated by severeC. perfringenscholangiosepsis.One of many possible pathogens of cholangitis, a rare but serious complication of ERCP, isC. perfringens. Infections due toC. perfringensshow evidence of tissue necrosis, bacteraemia, emphysematous cholecystitis and gas gangrene, also known as clostridial myonecrosis.