bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gestão Pública Estadual e suas Nuances Lesbianas no Contexto Amazônico
Authors: Silva Sebastiana 
Published: July 2018

<p><span>A palestra "Gestão Pública Estadual e suas Nuances Lesbianas no Contexto Amazônico" foi realizada em 11 de novembro de 2017 na Universidade Federal da Bahia, em Salvador. Essa escrita é resultado de uma apresentação na jornada "Pensamento Lésbico Contemporâneo", uma atividade de extensão do GIRA - Grupo de Estudos Feministas em Política e Educação, em parceria com o Coletivo Lesbibahia. Nesse relato, busco visibilizar a construção da política pública de gênero e sexualidade na Gerência Diversidade e Gênero da </span>Secretaria de Estado de Justiça, Direitos Humanos e Cidadania (SEJUSC) do estado do Amazonas, na perspectiva de uma equipe coordenada por uma lésbica negra, ativista, mãe, militante, feminista, servidora pública e filha da floresta amazônica.</p>
Graphene‐Based Smart Platforms for Combined Cancer Therapy
Authors: Gu Zhanjun , Zhu Shuang , Yan Liang , Zhao Feng , Zhao Yuliang 
Published: July 2018

AbstractThe extensive research of graphene and its derivatives in biomedical applications during the past few years has witnessed its significance in the field of nanomedicine. Starting from simple drug delivery systems, the application of graphene and its derivatives has been extended to a versatile platform of multiple therapeutic modalities, including photothermal therapy, photodynamic therapy, magnetic hyperthermia therapy, and sonodynamic therapy. In addition to monotherapy, graphene‐based materials are widely applied in combined therapies for enhanced anticancer activity and reduced side effects. In particular, graphene‐based materials are often designed and fabricated as “smart” platforms for stimuli‐responsive nanocarriers, whose therapeutic effects can be activated by the tumor microenvironment, such as acidic pH and elevated glutathione (termed as “endogenous stimuli”), or light, magnetic, or ultrasonic stimuli (termed as “exogenous stimuli”). Herein, the recent advances of smart graphene platforms for combined therapy applications are presented, starting with the principle for the design of graphene‐based smart platforms in combined therapy applications. Next, recent advances of combined therapies contributed by graphene‐based materials, including chemotherapy‐based, photothermal‐therapy‐based, and ultrasound‐therapy‐based synergistic therapy, are outlined. In addition, current challenges and future prospects regarding this promising field are discussed.
Mild Access to N‐Formylation of Primary Amines using Ethers as C1 Synthons under Metal‐Free Conditions
Authors: Mutra Mohana Reddy , Dhandabani Ganesh Kumar , Wang Jeh‐Jeng 
Published: July 2018

AbstractA new synthetic protocol has been developed for the synthesis of N‐formamide derivatives using ethers as a C1 synthon under metal‐free reaction conditions. The reaction is proposed to proceed through C−H functionalization, C−O cleavage, and C−N bond formation. This protocol is applicable to a variety of primary amines resulting in N‐formamides in moderate to good yields. 1,4‐dioxane was chosen as best C1 synthon after screening with various ethers. Mechanistic studies disclosed that the reaction proceeds through a radical pathway. While using α‐amino ketones a α‐alkylation product was formed rather than formylation. By replacing dioxane with Tetramethylethylenediamine (TMEDA) under standard conditions also gave the N‐formamide derivatives in moderate yields.magnified image
Synthesis of Cyclopropane Fatty Acids by C(sp3)−C(sp3) Cross‐Coupling Reaction and Formal Synthesis of α‐Mycolic Acid
Authors: Iwasaki Takanori , Terahigashi Shohei , Wang Yufei , Tanaka Arisa , Zhao Hanqing , Fujimoto Yukari , Fukase Koichi , Kambe Nobuaki 
Published: July 2018

AbstractAn iterative Ni‐catalyzed C(sp3)−C(sp3) cross‐coupling reaction of a novel cis‐cyclopropane containing bifunctional building blocks with alkyl halides and alkyl Grignard reagents enabled the introduction of a cyclopropane ring into the desired position(s) of saturated carbon frameworks, providing a straightforward synthetic route to cyclopropane fatty acids. The present method creates a direct route for the construction of saturated carbon frameworks, and can avoid the tedious multistep operations based on unsaturated functional group manipulations that are often employed in conventional synthetic routes. This method could be applicable to the synthesis of trans‐cyclopropane fatty acids and enantioenriched cyclopropane fatty acids. Formal synthesis of α‐mycolic acid was achieved by the C(sp3)−C(sp3) cross‐coupling reaction of cyclopropane‐containing bifunctional building blocks.magnified image
Pulmonary edema caused by inhalation of vapors from water‐soluble paint
Authors: Nakano Takaaki , Ito Toshitaka , Kanazawa Masashi , Kohno Hirotsugu , Imamura Tomonori , Takemoto Masaaki 
Published: July 2018

AimTo report the effects of inhaling vapor from water‐soluble paint after a recent encounter with 16 patients treated in our emergency department.MethodsWe examined a series of chest computed tomography (CT) images from the 16 affected patients. Computed tomography was carried out on days 1, 2, 5, and 19 after the inhalation event.ResultsTwelve of the patients were found to have pulmonary edema, based on their CT findings. Patients with pulmonary edema were classified as its persisted period. In the severe group, its pulmonary edema persisted over 5 days include, exacerbated edema, delayed‐onset edema (during the follow‐up), or edema amelioration. One patient had exacerbated edema, three patients had delayed‐onset edema, and one patient experienced amelioration of their edema in the severe group. In all cases, the pulmonary edema had disappeared from the CT images by day 19 after the inhalation event. Thirteen of the 16 patients had a fever of ≥37°C. Three kinds of solutes (ethylene glycol, titanium dioxide, and silicon oxide) had been blended in the water‐soluble paint. The titanium dioxide was considered the probable cause of the pulmonary edema.ConclusionInhalation of vapors from water‐soluble paints is considered relatively safe. However, our observations suggest that new lesions might develop and existing lesions could worsen, even if the edema is not severe immediately after the exposure. Thus, follow‐up imaging is needed for approximately 2 weeks in such cases.
Eine Calixaren‐basierte Metall‐organische Gerüstverbindung für den hoch selektiven NO2‐Nachweis
Authors: Schulz Marcel , Gehl Adrian , Schlenkrich Jakob , Schulze Hendrik A. , Zimmermann Stefan , Schaate Andreas 
Published: July 2018

AbstractEine Calixaren‐basierte Metall‐organische Gerüstverbindung (Zr‐cal, [Zr6O4(OH)4(FA)6]2(cal)3], FA=Formiat, cal=1,3‐alt‐25,26,27,28‐Tetrakis‐[(carboxy)methoxy]‐calixaren) wurde synthetisiert und ihre Struktur über Einkristallröntgendiffraktometrie bestimmt. Das dreidimensionale Gerüst kristallisiert in einem 4,6‐verbundenen Netzwerk in der gar‐Topologie und weist zwei identische, nicht miteinander verbundene Porensysteme auf. Die spezifische BET‐Oberfläche beträgt 670 m2 g−1 und die Kavitäten der Calixarene sind über das Porensystem zugänglich. Bei der Exposition mit NO2 bilden die Calixarene stark gefärbte Charge‐Transfer‐Komplexe im MOF, wodurch das Material zur visuellen Detektion und zur Einlagerung von NO2 genutzt werden kann. Die hohe Selektivität dieser Komplexierung wurde mittels IR‐ und UV/Vis‐Spektroskopie und die Stabilität des Materials mit Röntgenpulverdiffraktometrie und 1H‐NMR‐Spektroskopie überprüft. Schließlich wurde das MOF als Sensormaterial in einer selbstgebauten Messzelle verwendet, wo es eine hohe Sensitivität gegenüber NO2 aufwies.
Urban innovation policy in the postdevelopmental era: Lessons from Singapore and Seoul
Authors: Hartley Kris , Woo Jun Jie , Chung Sun Kyo 
Published: July 2018

AbstractThis article examines the impact of policies for start‐up and entrepreneurship on the developmental model that remains a policy legacy in many Asian countries. The main argument is that the influence of central planning is deeply embedded in the institutions of the Four Asian Tigers, but globalisation and economic liberalisation are disrupting the old developmentalism by incentivising innovation and structural adaptability. In practice, although developmentalism once focused on infrastructure and industrial policy, softer strategies such as attracting educated millennials through urban amenities and creative clustering mimic those of the postindustrial West. Either this trend represents the end of developmentalism or top‐down industrial policy is being rebranded to embrace knowledge and service industries. This article examines this issue at the urban scale, examining policies used by Singapore and Seoul to encourage start‐ups and entrepreneurship in the context of innovation. Government documents are examined and findings compared.
Human Urinary Kallidinogenase decreases recurrence risk and promotes good recovery
Authors: Han Dong , Chen Xin , Li Dongmei , Liu Shuang , Lyu Yi , Feng Juan 
Published: July 2018

AbstractObjectivesTo evaluate the efficacy of Human Urinary Kallidinogenase (HUK) for secondary stroke prevention in the treatment of acute ischemic stroke (AIS) patients.Materials and MethodsIn this retrospective study, from October 2016 to June 2017, 300 consecutive AIS patients were registered in our database. Among them, 145 patients received HUK treatment (HUK group), and 155 patients received basic treatment (control group). Basic treatment was administrated on all patients. 0.15 PNA unit of HUK injection plus 100 ml saline in intravenous infusion was performed in the HUK group, with once a day for 14 consecutive days. The rate of recurrent stroke and modified Rankin Scale (mRS) scores in two groups were analyzed 12 months after the treatment.ResultsNo difference was found in the age, gender, comorbidities, smoking history, and NIHSS scores between two groups before treatment (p > 0.05). 12 months after treatment, 10 patients in the HUK group (10.3%) and 26 patients in the control group (16.8%) got stroke recurrence at 12 months (p = 0.009). The mRS score of HUK group was significantly lower than that in the control group (2.3 ± 1.2 vs. 3.5 ± 1.4, p = 0.011).ConclusionHuman Urinary Kallidinogenase is able to reduce the risk of stroke recurrence and promote good recovery for AIS patients within 12 months.
Limb‐sparing surgery plus radiotherapy results in superior survival: an analysis of patients with high‐grade, extremity soft‐tissue sarcoma from the NCDB and SEER
Authors: Ramey Stephen J. , Yechieli Raphael , Zhao Wei , Kodiyan Joyson , Asher David , Chinea Felix M. , Patel Vivek , Reis Isildinha M. , Wang Lily , Wilky Breelyn A. , Subhawong Ty , Trent Jonathan C. 
Published: July 2018

AbstractSmall randomized trials have not shown an overall survival (OS) difference among local treatment modalities for patients with extremity soft‐tissue sarcomas (E‐STS) but were underpowered for OS. We examine the impact of local treatment modalities on OS and sarcoma mortality (SM) using two national registries. The National Cancer Database (NCDB) and the Surveillance, Epidemiology, and End Results (SEER) Program were analyzed separately to identify patients with stage II‐III, high‐grade E‐STS diagnosed between 2004 and 2013 and treated with (1) amputation alone, (2) limb‐sparing surgery (LSS) alone, (3) preoperative radiation therapy (RT) and LSS, or (4) LSS and postoperative RT. Multivariable analyses (MVAs) and 1:1 matched pair analyses (MPAs) examined treatment impacts on OS (both databases) and SM (SEER only). From the NCDB and SEER, 7828 and 2937 patients were included. On MVAs, amputation was associated with inferior OS and SM. Relative to LSS alone, both preoperative RT and LSS (HR, 0.70; 95% CI: 0.62‐0.78) and LSS and postoperative RT (HR, 0.69; 95% CI: 0.63‐0.75) improved OS in NCDB analyses with confirmation by SEER. Estimated median survivals from MPA utilizing NCDB data were 7.2 years with LSS alone (95% CI: 6.5‐8.9 years) vs 9.8 years (95% CI: 9.0‐11.2 years) with LSS and postoperative RT. A MPA comparing preoperative RT and LSS to LSS alone found median survivals of 8.9 years (95% CI: 7.9‐not estimable) and 6.6 years (95% CI: 5.4‐7.8 years). Optimal high‐grade E‐STS management includes LSS with preoperative or postoperative RT as evidenced by superior OS and SM.
TRIM65 is a potential oncogenic protein via ERK1/2 on Jurkat and Raji cells: A therapeutic target in human lymphoma malignancies
Authors: Wang Jin , Liang Xue , Yu Tao , Xu Yu‐Lin , Xu Li‐Hua , Zhang Xiao‐Jing , Ma Jie , Wang Yan‐Ru , He Shuang‐Li 
Published: July 2018

AbstractIn human lung cancer, Tripartite motif 65 (TRIM65) is documented as an important regulator in carcinogenesis. Knockdown of TRIM65 prevents the tumorigenesis of lung cancer cells, while TRIM65 overexpression presents the opposite effect. However, the roles of TRIM65 in human lymphocyte malignancies have reported little. Herein, we found that Jurkat (T‐lymphocyte) and Raji (B‐lymphocyte) expressed TRIM65. We aimed to investigate whether TRIM65 was a potential oncogenic protein that regulated the tumorigenesis of Jurkat and Raji cells. In our present study, cells were transfected with siRNA‐TRIM65 or TRIM65 overexpression vector, Cell counting kit‐8 (CCK‐8), Flow cytometry and Annexin V‐FITC/propidium iodide (PI) staining was carried out to detect cell viability, cell cycle profile and cell apoptosis, respectively. Extracellular signal‐regulated kinases 1/2 (ERK1/2) pathway‐associated proteins, such as Bcl2, cleaved‐caspase 3, vascular endothelial growth factor (VEGF), and phosphorylated ERK1/2 (p‐ERK1/2) were assessed. Our data indicated that knockdown of TRIM65 prevented the tumorigenesis of Jurkat and Raji cells. TRIM65 silencing inhibited cell proliferation, promoted cell apoptosis and arrested cell cycle, highly like through blocking ERK1/2 pathway. However, TRIM65 overexpression enhanced cell viability, increased the protein levels of Bcl2, VEGF, p‐ERK1/2 while decreased cleaved‐caspase 3 expression, suggesting the promoted effect of TRIM65 overexpression in the tumorigenesis of those two lymphoma cells. To validate the involvement of ERK1/2 pathway, ERK1/2 inhibitor AZD8330 (1 µmol/L) was introduced. We found that AZD8330 significantly prevented TRIM65 overexpression‐induced tumorigenesis. We concluded that TRIM65 served as a potential oncogenic protein on Jurkat and Raji cells, and ERK1/2 pathway was the underlying mechanism. Approaches targeting TRIM65 provided a novel strategy for the treatment of lymphoma.
Two transplant renal arteries: One important lesson
Authors: Koratala Abhilash , Mena Gutierrez Alejandra , Chamarthi Gajapathiraju , Zeng Xu , Alquadan Kawther F. 
Published: July 2018

Key Clinical MessageHigh index of suspicion is required for ischemic nephropathy in renal transplant recipients presenting with unexplained acute kidney injury, as it is potentially reversible. Carbon dioxide (CO2) angiogram is a good alternative to evaluate vasculature in patients with renal dysfunction where iodinated contrast is relatively contraindicated.
Hyperplastic gastric polyp with foci of ossification
Authors: Tsoucalas Gregory , Fiska Aliki 
Published: July 2018

Key Clinical MessageStromal ossification has been reported in relation with gastrointestinal (GI) cancers. Heterotopic ossification of benign gastric polyps with bone formation is rarely documented and sometimes associated with calcification. Thus, the presence of foci of metaplastic bone (FMB) does not always imply GI cancer.
Ultralow Overpotential of Hydrogen Evolution Reaction using Fe‐Doped Defective Graphene: A Density Functional Study
Authors: Lim Juhyung , Back Seoin , Choi Changhyeok , Jung Yousung 
Published: July 2018

AbstractWe report great promises of single (transition metal) atom catalysts (SACs) anchored to single‐ and double‐ vacancy sites of the defective graphene structures for hydrogen evolution reaction (HER). Among 120 candidates with all 3d, 4d, and 5d‐block transition metals considered, the inexpensive Fe‐based SAC catalyst shows a theoretical overpotential of 5 mV, the lowest value reported to date theoretically or experimentally. With the help of various electronic structural analysis, we reveal that the key to the observed superior HER activity of Fe‐based SAC is the enhanced ionicity of bonding between hydrogen and the corresponding SAC and the lack of ensemble effect that causes the *H binding weaker to be nearly at the top of the HER activity volcano.
Crystalline‐Water/Coordination Induced Formation of 3D Highly Porous Heteroatom‐Doped Ultrathin Carbon Nanosheet Networks for Oxygen Reduction Reaction
Authors: Liu Tingting , Feng Shi , Huo Jia , Li Qiling , Xie Chao , Wang Shuangyin 
Published: July 2018

AbstractDevelopment of highly efficient electrocatalysts with low cost for oxygen reduction reaction (ORR) is crucial for their application in fuel cells and metal‐air batteries. In this work, we report a synthesis of 3D heteroatom‐doped ultrathin carbon nanosheet networks directly starting from solid raw materials. This method represents an operationally simple, general, and sustainable strategy to various ultrathin carbon nanosheet networks. Evaporation of crystalline water and coordination interaction are proposed to be responsible for the formation of the 3D carbon nanosheet networks. The carbon nanosheet networks possess high surface area with micro‐ and macropores, large pore volume, ultrathin nanosheet structure, and effective N/S‐co‐doping. The as‐prepared materials show outstanding electrocatalytic ORR performance with more positive onset potential and half‐wave potential, good methanol tolerance, and excellent stability, compared with those of the porous carbons derived from the ZIF counterpart and commercial Pt/C. This work not only provides highly active ORR electrocatalysts via an operationally simple and green process and also demonstrates a general method to prepare 3D ultrathin carbon nanosheet networks without any additional template and solvent.
Recent Progress in Two‐Dimensional Antimicrobial Nanomaterials
Authors: Miao Hui , Teng Zhenyuan , Wang Chengyin , Chong Hui , Wang Guoxiu 
Published: July 2018

AbstractNowadays, microorganisms, including bacteria and viruses, are regarded as new environmental pollutants and pose serious threats to public health. Yet, traditional disinfection approaches for bacteria and viruses are generally ineffective. Furthermore, they exhibit the disadvantages of high‐energy consumption, environmental pollution, high cost, and toxic byproduct generation. In this respect, nanomaterials display promising antimicrobial capabilities due to their unique properties and provide solutions to the abovementioned issues. Herein, recent progress in the development of 2D nanomaterials displaying antimicrobial capabilities is highlighted. The structures, morphologies, and performances of essential metal, graphene, and nitride‐based 2D antibacterial nanomaterials are summarized in detail. In addition, possible antimicrobial mechanisms and the relationship between structure and antimicrobial efficiency are elaborated.
Synthesis, Nematicidal Activity, and 3D‐QSAR of Novel 1,3,4‐Oxadiazole/ Thiadiazole Thioether Derivatives
Authors: Chen Jixiang , Gan Xiuhai , Yi Chongfen , Wang Shaobo , Yang Yuyuan , He Fangcheng , Hu Deyu , Song Baoan 
Published: July 2018

AbstractForty one novel 1,3,4‐oxadiazole/thiadiazole thioether derivatives containing phenoxy moiety were designed and synthesized. Bioassay demonstrated that some of them showed remarkable activities against Tylenchulus semipenetrans in vitro and in vivo. Compounds 20, 21, 35 and 39 showed excellent lethal activities after treatment for 48 h in vitro, with LC50 values of 13.4 ± 1.8, 11.7 ± 2.5, 13.7 ± 2.4 and 13.3 ± 1.1 mg·L–1, respectively, which were obviously superior to fosthiazate (49.1 ± 2.8 mg·L–1) and avermectin (26.6 ± 2.3 mg·L–1). Compound 21 can effectively control the citrus nematode disease caused by T. semipenetrans at 200 mg·L–1 in vivo with (68 ± 3)% inhibitory effect, which was even better than that of avermectin ((63 ± 2)%). The CoMFA and CoMSIA models of three‐dimensional quantitative structure‐activity relationships (3D‐QSARs) were established. The compound 33 was designed based on the 3D‐QSAR models with more vigorous nematicidal activities in vitro (LC50 = 9.8 ± 1.4 mg·L–1) and in vivo ((70 ± 5)%). These results demonstrated that compound 33 can be considered as a potential nematicide.
Lattice Engineering on Metal Cocatalysts for Enhanced Photocatalytic Reduction of CO2 into CH4
Authors: Zhao Leihong , Ye Fan , Wang Dongmei , Cai Xiaotong , Meng Chenchen , Xie Hanshi , Zhang Jiali , Bai Song 
Published: July 2018

AbstractPhotocatalytic conversion of CO2 into CH4 represents an appealing approach to alleviate the world's continued reliance on fossil fuels and global warming resulting from increasing CO2 concentrations in the atmosphere. However, its practical application is greatly limited by serious electron–hole recombination in the photocatalysts and the production of CO and H2 as side reactions. Herein, for the first time, it is demonstrated that the photocatalytic reduction of CO2 to CH4 can be significantly improved through the simultaneous alloying and hydriding of metal cocatalysts. The isolation of Cu and H atoms in Pd lattices play three roles in the enhancement of CO2 to CH4 conversion: 1) Cu atoms provide catalytic sites to reduce CO2 into CO and then to CH4 to suppress H2 evolution; 2) H atoms improve the electron‐trapping ability of cocatalysts; and 3) H atoms accelerate the reduction of CO to CH4, which is the rate‐limiting procedure in the conversion of CO2 into CH4. Arising from the synergistic interplay between Pd−H and Cu−CO sites, C3N4−Pd9Cu1Hx (15 mg) achieves 100 % selectivity for CH4 production with an average rate of 0.018 μmol h−1 under visible‐light irradiation. This work provides insights into the design of a cocatalyst for highly selective CO2 conversion through lattice engineering at atomic precision.
Spawning behavior of Arctic charr (Salvelinus alpinus): Spawning synchrony, vibrational communication, and mate guarding
Authors: Brattli Magnus B. , Egeland Torvald B. , Nordeide Jarle T. , Folstad Ivar 
Published: July 2018

AbstractA mismatch in synchrony between male and female gamete release in external fertilizers can result in reduced or failed fertilization, sperm competition, and reduced paternity. In Arctic charr (Salvelinus alpinus), males can adopt either a guard or sneak tactic resulting in both pre‐ and postcopulatory competition between males with alternative reproduction tactics. Here, spawning behavior of free‐living Arctic charr was video‐recorded, and their reproductive behavior was analyzed. From evaluating 157 spawning events, we observed that females mainly spawned with a guarding male and that the female and the guarding male synchronized timing of gamete release under sperm competition. Although sneakers spawned with higher synchrony than the guarding male in single‐male spawning events, the average sneaker released his milt less synchronized with the female than the guarding male under sperm competition. Approximately 50% of the recorded spawning events occurred under sperm competition, where each event included an average of 2.7 males. Additionally, sneakers were more exposed to sperm competition than guarding males. An influx of males, in close proximity to the female, occurred during the behavioral sequences leading up to egg release, but this influx seemed not dependent on egg release, suggesting that something else than gonadal product attracts sneaker males to the spawning female. Just before and during the actual release of gametes, the spawning couple vibrates their bodies in close contact and it seems likely that this vibrational communication between the spawning couple, which results in a larger amplitude sound wave than seen under regular courting, reveals time of gamete release to sneaker males. Thus, vibrational communication may enable synchrony between the guarding male and the female, and this might be traded against the cost of higher detectability from surrounding sneaker males, eavesdropping in close proximity.