bluuebunny/crossref_metadata_2025_split huggingface dataset:
18F-AV1451 PET imaging and white matter changes in progressive supranuclear palsy
Authors: Nicastro Nicolas , Vazquez Rodriguez Patricia , Malpetti Maura , Bevan-Jones William Richard , Jones P. Simon , Passamonti Luca , Aigbirhio Franklin I. , O’brien John T. , Rowe James B. 
Published: June 2019

ABSTRACTIntroductionProgressive supranuclear palsy (PSP) is characterized by deposition of straight filament tau aggregates in the grey matter of deep nuclei and cerebellum. White matter changes are increasingly documented as a feature of degenerative parkinsonism. We therefore examined the relationship between tau pathology (assessed via 18F-AV1451 positron emission tomography) and white matter integrity (using diffusion tensor imaging, DTI) in PSP.MethodsTwenty-three people with clinically probable PSP-Richardson’s syndrome (age 68.8 ± 5.8 years, 39% female) and 23 controls underwent structural 3T brain MRI including DTI. Twenty-one patients also underwent 18F-AV145 PET imaging. DTI group comparisons were performed using Fractional Anisotropy (FA), Mean Diffusivity (MD) and Radial Diffusivity (RD). Voxel-wise white matter integrity was correlated with 18F-AV1451 binding in typical subcortical PSP regions of interest (i.e. putamen, pallidum, thalamus and midbrain). DTI and 18F-AV1451 imaging measures were correlated with clinical impairment.ResultsWidespread DTI changes in PSP subjects relative to controls (family-wise error FWE p<0.01) were observed. In PSP, higher 18F-AV1451 binding correlated with reduced white matter integrity in the bilateral internal capsule, corona radiata, and superior longitudinal fasciculus (FWE p<0.05). Association between cognitive impairment (ACER score) and white matter deficits were found in the genu of corpus callosum and cingulum (p<0.005).ConclusionThis cross-sectional study demonstrates an association between in vivo proxy measures of tau pathology and white matter degeneration in PSP. Longitudinal studies and more specific PET probes for non-Alzheimer tauopathies are warranted to assess the complex interplay between microstructural changes and protein deposition in PSP.
Transfer of Statistical Innovations of the 1990s-2000s in Oncology to the Biomedical Literature
Authors: Vivot Alexandre , Lévy Vincent , Chevret Sylvie 
Published: June 2019

ABSTRACTIntroductionInnovations in the fields of clinical studies require time to generate and disseminate new knowledge. We aimed to specifically explore lag times between the introduction and widespread use of innovative statistical methods in oncology using the competing risks and phase I model-based clinical trials settings as examples.MethodsFirst, we defined a set of closed articles for each setting based on two princeps papers (Gray, Annals of Statistics 1998 for the competing risks setting and O’Quigley et al., Biometrics 1990 for the phase I setting). Secondly, we retrieved from the web of science all citations of the papers included in these sets. Each journal was classified as applied, semi-applied or methodological.ResultsA total of 6,727 citations for the competing risks setting and 2,639 citations for the phase I setting were found. Time to reach 25 citations was 6.2 years for the Gray’s paper and 4.5 years for the Fine and Gray paper, while it ranged from 3.4 years up to at least 20.1 years and not reached for 6 papers from the competing risks setting. The vast majority (91%) of the citing papers for the competing risks setting originated from applied journals. In contrast, less than half (44%) of the citing papers for the phase I setting were published in applied journals.ConclusionStatistical innovations in the competing risks setting have been widely diffused in the medical literature unlike the model-based designs for phase I trials, which are still seldom used 30 years after publication.
Pain Reduction by Inducing Sensory-Motor Adaptation in Complex Regional Pain Syndrome (CRPS PRISMA): Protocol for a Double-blind Randomized Controlled Trial
Authors: Halicka Monika , Vittersø Axel D , Proulx Michael J , Bultitude Janet H 
Published: June 2019

AbstractBackgroundComplex Regional Pain Syndrome (CRPS) presents as chronic, continuous pain and sensory, autonomic, and motor abnormalities affecting one or more extremities. People with CRPS can also show changes in their perception of and attention to the affected body part and sensory information in the affected side of space. Prism Adaptation (PA) is a behavioural intervention targeted at reducing attention deficits in post-stroke hemispatial neglect. PA also appears to reduce pain and other CRPS symptoms; however, these therapeutic effects have been demonstrated only in small unblinded studies. This paper describes the protocol for an ongoing double-blind, randomized, sham-controlled clinical trial that will evaluate the efficacy of PA treatment for CRPS. The secondary aims of the study are to examine the relationships between neuropsychological changes (such as spatial attention, space and body representation, and motor spatial performance) and clinical manifestations of CRPS, as well as symptom improvement.MethodsForty-two participants with upper-limb CRPS type I will undergo two weeks of twice-daily PA treatment or sham treatment. The primary outcome measures are current pain intensity and CRPS severity score, measured immediately before and after the treatment period. Secondary outcome measures include the results of self-report questionnaires about pain, movement, symptoms interference, and body representation; clinical assessments of sensory, motor, and autonomic functions; and computer-based psychophysical tests of neuropsychological functions. Data are collected in four research visits: four weeks and one day before treatment, and one day and four weeks after the end of treatment. Additional follow-up through postal questionnaires is conducted three and six months post-treatment.DiscussionIt is hypothesised that participants undergoing PA treatment, compared to those receiving sham treatment, will show greater reduction in pain and CRPS severity score, and improvements on other clinical and neuropsychological measures. Also, more pronounced neuropsychological symptoms are predicted to correlate with more severe clinical CRPS symptoms. This study will provide the first randomized double-blind evaluation of the therapeutic effects of PA that could be implemented as a rehabilitation method for CRPS, and will contribute to the understanding of how neuropsychological changes in body representation and attention pertain to the manifestation and treatment of CRPS.
Arabidopsis HY1-Modulated Stomatal Movement: An Integrative Hub Is Functionally Associated with ABI4 in Dehydration-Induced ABA Responsiveness
Authors: Xie Yanjie , Mao Yu , Duan Xingliang , Zhou Heng , Lai Diwen , Zhang Yihua , Shen Wenbiao 
Published: June 2019

Abstract
Heme oxygenase (HO; EC 1.14.99.3) has recently been proposed as a novel component in mediating wide ranges of the plant adaptive signaling processes. However, the physiological significance and molecular basis underlying Arabidopsis (Arabidopsis thaliana) HO1 (HY1) functioning in drought tolerance remained unclear. Here, we report that mutation of HY1 promoted, but overexpression of this gene impaired, Arabidopsis drought tolerance. This was attributed to the abscisic acid (ABA)-hypersensitive or -hyposensitive phenotypes, with the regulation of stomatal closure in particular. However, comparative transcriptomic profile analysis showed that the induction of numerous ABA/stress-dependent genes in dehydrated wild-type plants was differentially impaired in the hy1 mutant. In agreement, ABA-induced ABSCISIC ACID-INSENSITIVE4 (ABI4) transcript accumulation was strengthened in the hy1 mutant. Genetic analysis further identified that the hy1-associated ABA hypersensitivity and drought tolerance were arrested in the abi4 background. Moreover, the promotion of ABA-triggered up-regulation of RbohD abundance and reactive oxygen species (ROS) levels in the hy1 mutant was almost fully blocked by the mutation of ABI4, suggesting that the HY1-ABI4 signaling in the wild type involved in stomatal closure was dependent on the RbohD-derived ROS production. However, hy1-promoted stomatal closure was not affected by a nitric oxide scavenger. Correspondingly, ABA-insensitive behaviors in rbohD stomata were not affected by either the mutation of HY1 or its ectopic expression in the rbohD background, both of which responded significantly to exogenous ROS. These data indicate that HY1 functioned negatively and acted upstream of ABI4 in drought signaling, which was casually dependent on the RbohD-derived ROS in the regulation of stomatal closure.
The effects of flow separation on a lambda wing aerodynamics
Authors: Dadkhah Mehdi , Masdari Mehran , Vaziri Mohammad Ali , Tahani Mojtaba 
Published: June 2019

Purpose
In this paper, experimental and numerical results of a lambda wing have been compared. The purpose of this paper is to study the behaviour of lambda wings using a CFD tool and to consider different numerical models to obtain the most accurate results. As far as the consideration of numerical methods is concerned, the main focus is on the evaluation of computational methods for an accurate prediction of contingent leading edge vortices’ path and the flow separation occurring because of the burst of these vortices on the wing.

Design/methodology/approach
Experimental tests are performed in a closed-circuit wind tunnel at the Reynolds number of 6 × 105 and angles of attack (AOA) ranging from 0 to 10 degrees. Investigated turbulence models in this study are Reynolds Averaged Navior–Stokes (RANS) models in a steady state. To compare the accuracy of the turbulence models with respect to experimental results, sensitivity study of these models has been plotted in bar charts.

Findings
The results illustrate that the leading edge vortex on this lambda wing is unstable and disappears soon. The effect of this disappearance is obvious by an increase in local drag coefficient in the junction of inner and outer wings. Streamlines on the upper surface of the wing show that at AOA higher than 8 degrees, the absence of an intense leading edge vortex leads to a local flow separation on the outer wing and a reverse in the flow.

Research limitations/implications
Results obtained from the behaviour study of transition (TSS) turbulence model are more compatible with experimental findings. This model predicts the drag coefficient of the wing with the highest accuracy. Of all considered turbulence models, the Spalart model was not able to accurately predict the non-linearity of drag and pitching moment coefficients. Except for the TSS turbulence model, all other models are unable to predict the aerodynamic coefficients corresponding to AOA higher than 10 degrees.

Practical implications
The presented results in this paper include lift, drag and pitching moment coefficients in various AOA and also the distribution of aerodynamic coefficients along the span.

Originality/value
The presented results include lift, drag and pitching moment coefficients in various AOA and also aerodynamic coefficients distribution along the span.
On-farm food safety knowledge, attitudes and self-reported practices of layer hen farmers
Authors: Thongpalad Kwanhatai , Kuwornu John K.M. , Datta Avishek , Chulakasian Songkhla , Anal Anil Kumar 
Published: June 2019

PurposeThe purpose of this paper is to assess the knowledge, attitudes and practices (KAP) of farmers regarding the on-farm food safety measures in the commercial layer farms in Thailand prior the implementation of the mandatory Good Agricultural Practices (GAP) standard.Design/methodology/approachThe cross-sectional study was conducted through the face-to-face interview with a questionnaire in 143 GAP certified and 59 non-GAP certified farms. The levels of safety and quality measures implemented in farms were evaluated using a self-reported approach. Scoring system was applied to investigate the relationship between level of practices and its determining factors using the correlation test.FindingsThe layer hen farmers appeared to have an adequate level of knowledge on safety and quality measures; however, some misconception on recommended practices was still observed. The significant differences (p<0.001) in the regularity of practices adopted in farms were noticed between GAP and non-GAP groups. The GAP farmers have higher level of knowledge, and positive attitudes toward implementation. Only the weak positive relationships were found between all KAP variables which implied that there are other factors influencing the translation of knowledge and favorable attitudes into practices.Originality/valueNone of the on-farm food safety KAP report has been published in Thailand. This study highlights the gaps in the practices and issues needed to be focused by standard promoters for developing the knowledge translation programs aimed at enhancing the standard of layer farming.
The wide range of output frequency regulation method for the inverter using the combination of PWM and DDS
Authors: Pietrowski Wojciech , Ludowicz Wojciech , Wojciechowski Rafal Marek 
Published: June 2019

Purpose
The specific modulation methods are used to control different kind of single-phase, as well as three-phase, inverters to ensure flexibility and high quality of the output waveform. This paper aims to present a combination of two classical methods, namely, pulse width modulation method and direct digital synthesis modulation method.

Design/methodology/approach
The total harmonic distortion of output waveforms of single-phase inverter based on elaborated modulation method has been determined by means of fast Fourier transform analysis. Tests have been carried out by using standard low-frequency application and also a wireless resonant energy link system.

Findings
Applying appropriate timer parameters of microcontroller enables to obtain a waveform for given output parameters (amplitude, frequency, frequency modulation index, etc.). The only limitation is the computing power of a microcontroller.

Originality/value
The elaborated method can be successfully used in both low- and high-frequency application ensuring high level of output waveform quality. Additional signal generators and the control of amplitude modulation ratio are no longer indispensable, what simplify immensely a control system.
Nature of communication performance in non-traditional procurements in South Africa
Authors: Kwofie Titus Ebenezer , Aigbavboa Clinton Ohis , Machethe Seja Olgah 
Published: June 2019

Purpose
Non-traditional procurement is thought to offer enhanced benefits over traditional contracts. However, several factors significantly impacting the optimization of the benefits have been suggested. Even though effective communication is ranked high among these factors, not enough empirical insights have been given to the nature of communication performance in non-traditional procurements in construction project delivery. The purpose of this paper is to focus on understanding the taxonomy of communication performance in non-traditional procurements in the South African Construction Industry, given the centrality of communication to team effectiveness, performance, project success and managerial efficiency.

Design/methodology/approach
Adopting a deductive research approach, an empirical questionnaire survey was conducted drawing on the practical communication experience of project teams engaged in projects using non-traditional procurement systems.

Findings
Using aggregated mean scores and inter-rater agreement index and Mann‒Whitney tests, the results revealed inaccuracies, barriers and procedural challenges as frequently occurring in the interpersonal and organizational communication in the adopted non-traditional procurement systems. Additionally, untimeliness and distorted information were noted to be occurring occasionally, whereas incomplete communication, misunderstood information and gatekeeping rarely occurred. Lastly, protocol-related communication challenges were deemed to have never occurred in their interpersonal and organizational communication in their project delivery. In the assessment of communication performance, the less frequently occurring assessment indicator is a testament to good communication performance, whereas the frequently occurring indicator represents a poor performance in the communication.

Originality/value
This systematic approach toward understanding the taxonomy of the interpersonal and organizational communication performance in non-traditional procurement is very significant toward communication performance improvement in the industry. The insight given by the findings may help construction project practitioners to focus their attention on the necessary aspects of communication in non-traditional procurements to optimize their benefits over traditional procurement models.
Neuroscientism, the neuroscience of learning
Authors: Lim Doo Hun , Chai Dae Seok , Park Sunyoung , Doo Min Young 
Published: June 2019

Purpose
Although the field of neuroscience has evolved dramatically, little research has attempted to conceptualize the impact of neuroscience on the field of human resource development (HRD). The purpose of this study is an integrative review of the influential relationship between neuroscience and workplace learning including applicable implications for HRD research and practice.

Design/methodology/approach
By reviewing 93 studies on neuroscience and brain-based learning published between 1995 and 2017, the authors synthesized their findings.

Findings
This study discusses the basic concepts of neuroscience such as the structure and functions of the brain, neuroscientific findings about memory and cognition, the effect of neural transmitters on memory and cognition and the neuroscience of learning. This study also illustrates brain-based learning styles affecting learning and describes various neuroscientific learning principles and models that can be applied to practical planning and the delivery of workplace learning and HRD activities.

Originality/value
This study concludes with brain-based learning principles called neuroscientism compared with traditional learning theories. It also includes several brain-based learning cases from workplace settings and implications for future research and further HRD practices.
Numerical investigation of the effect of water/Al2O3 nanofluid on heat transfer in trapezoidal, sinusoidal and stepped microchannels
Authors: Jaferian Vahid , Toghraie Davood , Pourfattah Farzad , Akbari Omid Ali , Talebizadehsardari Pouyan 
Published: June 2019

Purpose
The purpose of this study is three-dimensional flow and heat transfer investigation of water/Al2O3 nanofluid inside a microchannel with different cross-sections in two-phase mode.

Design/methodology/approach
The effect of microchannel walls geometry (trapezoidal, sinusoidal and stepped microchannels) on flow characteristics and also changing circular cross section to trapezoidal cross section in laminar flow at Reynolds numbers of 50, 100, 300 and 600 were investigated. In this study, two-phase water/Al2O3 nanofluid is simulated by the mixture model, and the effect of volume fraction of nanoparticles on performance evaluation criterion (PEC) is studied. The accuracy of obtained results was compared with the experimental and numerical results of other similar papers.

Findings
Results show that in flow at lower Reynolds numbers, sinusoidal walls create a pressure drop in pure water flow which improves heat transfer to obtain PEC < 1. However, in sinusoidal and stepped microchannel with higher Reynolds numbers, PEC > 1. Results showed that the stepped microchannel had higher pressure drop, better thermal performance and higher PEC than other microchannels.

Originality/value
Review of previous studies showed that existing papers have not compared and investigated nanofluid in a two-phase mode in inhomogeneous circular, stepped and sinusoidal cross and trapezoidal cross-sections by considering the effect of changing channel shape, which is the aim of the present paper.
Contemporary ethnic minority entrepreneurship in the UK
Authors: Daniel Elizabeth , Henley Andrew , Anwar Muhammad Naveed 
Published: June 2019

Purpose
Ethnic minority entrepreneurs (EMEs) are traditionally associated with lower growth industry sectors. The purpose of this paper is to draw on the theory of mixed embeddedness to determine if more recent EMEs have been able to break out of lower growth sectors and if break out varies across ethnic minority groups. It also compares entrepreneurial quality in terms of weekly hours worked, weekly earnings and job satisfaction.

Design/methodology/approach
Quantitative inferential statistical analysis is undertaken on data drawn from the large scale, social sciences data set for the UK, Understanding Society.

Findings
The study finds that break out is not associated with being a recent EME but does vary across ethnic minority groups. Break out is found to be associated with gender, education, English language proficiency and occupational status. Some variation in entrepreneurial quality is found for both recent EMEs and across ethnic minority groups.

Practical implications
Understanding the nature and quality of ethnic minority entrepreneurship is important since it informs public debate about migration, informs policy and shapes activities of future EMEs.

Originality/value
The study provides a theoretically grounded interpretation of the explanatory variables associated with EME break out and entrepreneurial quality. Second, it provides a large confirmatory study of break out and finally, it also finds an important empirical nuance to the concept of opportunity structure by identifying a variation over time in both external and socio-demographic factors.
Paradoxical influence of family ownership on innovation-focused organizational change
Authors: Szymanska Izabela , Blanchard Anita , Kuhns Kaleigh 
Published: June 2019

PurposeThe purpose of this paper is to focus on efforts of a large department store to increase its business advantage by boosting innovation. The first broad research question of this study investigated how the family and non-family members influence the process of organizational change aimed at greater innovativeness in a successful retail family business. The second research question was how the family enterprise handles the tension between change stemming from innovation and progress and the need for stability continuity tradition and maintenance of family control.Design/methodology/approachThis study is an in-depth inductive analysis (Glaser and Strauss, 1967) of an important and unique case (Yin, 1994).FindingsThe results of the study indicate that the push toward innovation was initiated by family members and that it was focused largely on creating structural support for the innovation activity keeping this activity tightly under monitoring and control by upper management. The attempts at equipping employees with innovation-relevant decision-making authority or consulting the clients in designing novel projects were absent, while the move to change the organizational culture was measured.Originality/valueThis study makes several contributions to the academic literature. It offers an empirical assessment of the effects of emotional attachment and ownership concentration on innovation management, a phenomenon postulated by Kotlaret al.(2016). These two characteristics pulled innovation-boosting initiative in opposite directions creating a unique dynamics. This research also provides an example of organizational identity that hinders the innovation process in the context of a family business that survived and developed over generations.