bluuebunny/crossref_metadata_2025_split huggingface dataset:
H3.3K4M destabilizes enhancer epigenomic writers MLL3/4 and impairs adipose tissue development
Authors: Jang Younghoon , Wang Chaochen , Broun Aaron , Park Young-Kwon , Zhuang Lenan , Lee Ji-Eun , Froimchuk Eugene , Liu Chengyu , Ge Kai 
Published: April 2018

AbstractHistone H3K4 mono-methyltransferases MLL3 and MLL4 (MLL3/4) are required for enhancer activation during cell differentiation, though the mechanism is incompletely understood. To address MLL3/4 enzymatic activity in enhancer regulation, we have generated two mouse lines: one expressing H3.3K4M, a lysine-4-to-methionine (K4M) mutation of histone H3.3 that inhibits H3K4 methylation, and the other carrying conditional double knockout of MLL3/4 enzymatic SET domains. Expression of H3.3K4M in lineage-specific precursor cells depletes H3K4 methylation and prevents adipogenesis and adipose tissue development. Mechanistically, H3.3K4M prevents enhancer activation in adipogenesis by destabilizing MLL3/4 proteins but not other Set1-like H3K4 methyltransferases. Notably, deletion of the enzymatic SET domain of MLL3/4 in lineage-specific precursor cells mimics H3.3K4M expression and prevents adipose tissue development. Interestingly, destabilization of MLL3/4 by H3.3K4M in adipocytes does not affect adipose tissue maintenance and function. Together, our findings indicate that H3.3K4M destabilizes enhancer epigenomic writers MLL3/4 and impairs adipose tissue development.
NDUFAB1 Protects Heart by Coordinating Mitochondrial Respiratory Complex and Supercomplex Assembly
Authors: Hou Tingting , Zhang Rufeng , Jian Chongshu , Ding Wanqiu , Wang Yanru , Ma Qi , Hu Xinli , Cheng Heping , Wang Xianhua 
Published: April 2018

AbstractThe impairment of mitochondrial bioenergetics, often coupled with exaggerated reactive oxygen species (ROS) production, is emerging as a common mechanism in diseases of organs with a high demand for energy, such as the heart. Building a more robust cellular powerhouse holds promise for protecting these organs in stressful conditions. Here, we demonstrate that NDUFAB1 (NADH:ubiquinone oxidoreductase subunit AB1), acts as a powerful cardio-protector by enhancing mitochondrial energy biogenesis. In particular, NDUFAB1 coordinates the assembly of respiratory complexes I, II, and III and supercomplexes, conferring greater capacity and efficiency of mitochondrial energy metabolism. Cardiac-specific deletion of Ndufab1 in mice caused progressive dilated cardiomyopathy associated with defective bioenergetics and elevated ROS levels, leading to heart failure and sudden death. In contrast, transgenic overexpression of Ndufab1 effectively enhanced mitochondrial bioenergetics and protected the heart against ischemia-reperfusion injury. Our findings identify NDUFAB1 as a central endogenous regulator of mitochondrial energy and ROS metabolism and thus provide a potential therapeutic target for the treatment of heart failure and other mitochondrial bioenergetics-centered diseases.
Scheduling multiple servers to facilitate just-in-time part-supply in automobile assembly lines
Authors: Peng Tao , Zhou Binghai 
Published: April 2018

Purpose
With regard to product variety and cost competition, just-in-time (JIT) part-supply has become a critical issue in automobile assembly lines (AALs). This paper aims to investigate a multiple server scheduling problem (MSSP) encountered in the JIT part-supply process of AALs. Parts are stored in boxes and allotted from the JIT-supermarket to consumptive stations with a multiple server system. The schedule is to dispatch and sequence material boxes on each server for minimizing line-side inventory levels.

Design/methodology/approach
A mixed integer linear programming (MILP) model is established to formulate the proposed MSSP to pave the way for CPLEX procedure. Considering the high complexity of MSSP, a hybrid ant colony optimization (HACO) approach is developed by integrating basic ant colony optimization (ACO) with local optimizers that comprise of a fast local search and a tailored breadth-first tree search method.

Findings
Both CPLEX and HACO approach are capable of solving small-scale instances to optimality within reasonable computation time. The proposed HACO has been well enhanced with the embedded fast local search and tailored breadth-first tree search, and it performs robustly in a statistically significant manner when applied to real-world scale instances.

Originality/value
No stock-outs constraints and weighted line-side inventory level are considered in this paper, and the MSSP is solved satisfactorily to facilitate an efficient JIT part-supply of the AAL. In terms of the algorithm design, a tree search-based local optimizer is embedded into ACO to combine the mechanisms of ACO and problem-specific optimization.
Melting heat transfer analysis of non-Newtonian Casson fluid due to moving plate
Authors: Nandeppanavar Mahantesh M. 
Published: April 2018

Purpose
This paper aims to investigate laminar boundary layer flow and heat transfer from a warm laminar Casson liquid to a melting sheet moving parallel to a melting stream. The governing equations, i.e. continuity, momentum and heat transfer, are coupled non-linear partial differential equations. These equations are reduced to non-linear ordinary differential equations by means of similarity transformations, converted into first-order differential equations, and are solved numerically using the Runge–Kutta–Felhberg method with an efficient shooting technique. The velocity and temperature profiles are plotted for various values of the governing parameters, such as the moving parameter, Prandlt number, melting parameter and Casson parameter. It is found that the problem admits multiple solutions. The results of this study are validated by comparing them with the earlier published studies’ results. Thus, a good agreement is obtained.

Design/methodology/approach
This study carries out numerical solution of melting heat transfer analysis.

Findings
The findings of this study show the analysis of flow and melting heat transfer characteristics.

Research limitations/implications
In this study, analysis of dual solution is carried out.

Originality/value
In this paper, the melting heat transfer analysis on Blasius flow of a Casson fluid is taken into consideration. To the best of the author’s knowledge, no investigations have been reported on this topic.
Experimental and numerical studies on flow behavior of surface defects in the heavy rail rolling
Authors: Pan Chenggang , Ding Zizheng , Chang Qingming , Zhou Jialin 
Published: April 2018

Purpose
Surface defects are often present on the surface of continuous casting slabs and rolled products. A lot of surface defects of hot rolled products are inherited from initial defects on continuous casting slabs. This work aims to trace the original surface defect during the whole heavy rail rolling and avoid black line surface defect that appears on the surface of heavy rail finial product.

Design/methodology/approach
Artificial round hole-shaped surface defects on the surface of continuous casting slab during the hot rolling of 60 kg/m heavy rail are analyzed experimentally and by means of explicit dynamic finite element method (FEM) and modified model rebuilding method.

Findings
The calculated results of surface defect locations of heavy rail finial product are in good agreement with the experimental ones. It is shown that the explicit dynamic FEM and modified model rebuilding method can be used effectively to predict the flow behavior of surface defects in the hot rolling of 60 kg/m heavy rail.

Originality/value
The three-dimensional finite element model for whole heavy rail rolling is built using explicit dynamic code and modified model rebuilding method. Flow behavior of black lines is studied in the 60-kg/m heavy rail rolling. The simulation results of six typical points are in good agreement with the experimental results.
Analysis of consolidation behavior of PVD-improved ground considering a varied discharge capacity
Authors: Kim Yun Tae , Nguyen Ba-Phu , Yun Dae-Ho 
Published: April 2018

PurposeIt is well-known that consolidation rate of prefabricated vertical drain (PVD)-installed ground is closely related to the discharge capacity of PVD, which decreases with an increase in effective stress. This paper aims to present consolidation behaviors of PVD-improved ground considering a varied discharge capacity of PVD.Design/methodology/approachA simple equivalent vertical hydraulic conductivity (k′vemethod) was proposed in plane strain numerical analysis, in which the effect of decreased discharge capacity with depth was considered. Numerical analysis was applied to analyze field behaviors of test embankment of soft mucky deposit.FindingsFinite element method results indicated that consolidation behaviors of PVD-improved soil with a nonlinear distribution of discharge capacity with depth were in a good agreement with the observed field behaviors, compared with those with a constant discharge capacity and a linear distribution of discharge capacity. At a given time and depth, the consolidation rate in the case of discharge capacity with a nonlinear distribution is lower than that of a linear or constant distribution.Practical implicationsA geotechnical engineer could use the proposed method to predict consolidation behaviors of drainage-installed ground.Originality/valueConsolidation behaviors of PVD-installed ground could be reasonably predicted by using the proposed method with considering effect of discharge capacity reduction.
Modeling soil-plant-water interaction
Authors: Gadi Vinay , Singh Shivam , Singhariya Manish , Garg Ankit , S. Sreedeep , K. Ravi 
Published: April 2018

PurposeThe purpose of this paper is to numerically investigate the combined effects of canopy (leaf area index [LAI]) and root properties (root distribution function [Rdf] and root area index [RAI]) on a suction induced in soil-root composite under three different scenarios.Design/methodology/approachRichards equation coupled with sink term was solved using a commercial finite element package “HYDRUS” to investigate suction induced in soil-root composite.FindingsScenario 1 unveiled that soil-root composite induces 1 to 20 per cent higher suction than bare soil under the absence of transpiration. From Scenario 2, value of suction at depth of maximum RAI in case of linearly decreasing Rdf was found to be higher than that of other Rdfs. However, depth of suction influence zone (SIZ) for uniform Rdf and non-linear Rdf was found to be 10 and 11 per cent higher than that of linearly decreasing Rdf. Depth of evaporation dominant zone (EDZ) for uniformly decreasing Rdf and non-linear Rdf was found to be 1.08 to 3 times higher than that of linearly decreasing Rdf. From Scenario 3, influence of LAI on depth of SIZ is minimal. Depth of EDZ was found to decrease with the increase in LAI. Based on simple calculation on infinite slope stability, influence of variation in root and shoot properties was found to be significant on its factor of safety.Research limitations/implicationsNumerical constitutive model has limitations that it does not consider aging of plant. This model is only applicable for a particular set of soil conditions. A long-term study is required in this field to further quantify parameters for improving calibration and modeling performance.Practical implicationsFollowing are the practical implication: consideration of vegetation properties into engineered design of green infrastructure (slopes in this case) and selection of vegetation with appropriate characteristics in design for enhancement of stability of green infrastructure.Originality/valueContents of this paper are original, and they have not been submitted to any other journal.
Effect of corrugated skins on the aerodynamic performance of the cambered airfoils
Authors: Kharati-koopaee Masoud , Fallahzadeh-abarghooee Mahmood 
Published: April 2018

Purpose
This paper aims to study the effect of corrugated skins on the aerodynamic performance of the cambered NACA 0012 airfoils at different corrugations parameters, maximum cambers, Reynolds numbers and maximum camber locations.

Design/methodology/approach
In this work, numerical approach is concerned, and results are obtained based on the finite volume approach. To characterize the effect of corrugated skins, the NACA 0012-corrugated airfoil section is chosen as the base airfoil, and different cambered corrugated airfoil sections are obtained by inclusion the camber to the base airfoil. In this research, the corrugation shape is a sinusoidal wave and corrugated skins are in the aft 30 per cent of airfoil chord. To investigate the effect of corrugations on the cambered sections, the drag coefficient and averaged lift curve slope for the corrugated airfoils are compared to those of the corresponding smooth sections.

Findings
Results indicate that the effect of increase in the maximum camber and also Reynolds number on the relative zero-incidence drag coefficient is of little importance at low corrugation amplitudes, whereas at high corrugation, amplitude results in different behaviors. It is found that as the maximum camber increases, the deterioration in the relative curve slope introduced by corrugated skins is reduced, and reduction in this deterioration is significant for high corrugation amplitudes airfoils. It is shown that an increase in the maximum camber location has nearly no effect on the relative zero-incidence drag coefficient and also relative lift curve slope.

Originality/value
The outcome of the present research provides the clues for better understanding of the effect of different corrugations parameters on the aerodynamic performance of the unmanned air vehicles to have as high aerodynamic performance as possible in different mission profiles of such vehicles.
Healthcare systems: typologies, framework models, and South Africa’s health sector
Authors: Katuu Shadrack 
Published: April 2018

Purpose
A healthcare system in any country is rarely the product of one logical policy-making experience, but rather a manifestation of many years of historical development. The purpose of this paper is to examine the characteristics, components, and variables of South Africa’s healthcare system in the context of global patterns. It leverages a dynamic period in South Africa since 1994, and applies a comparative health systems analysis to explain where the country’s healthcare system is, and where it is potentially going.

Design/methodology/approach
This paper reviews literature related to South Africa’s healthcare system, outlines its historical development, and discusses three fundamental challenges experienced in the country. This paper also reviews the literature on healthcare system typologies and identifies three framework models that have been used to categorise national healthcare systems since the 1970s. This paper then discusses the categorisation of South Africa’s healthcare system in these models, in comparison to Canada and the USA.

Findings
This paper finds that the framework models are useful tools for comparative analysis of healthcare systems. However, any use of such typologies should be done with the awareness that national healthcare systems are not isolated entities because they function within a larger context. They are not static, since they are constantly evolving with many nuances, even with very similar healthcare system categorisations.

Originality/value
This paper charts the trajectory of change in the South African healthcare system, and demonstrates that the change process must keep internal conditions in mind if the outcome is to be successful. Imitating policies of countries with well-functioning systems, without regard to local realities, may not work, as the government attempts to usher in changes within a short span of time.
Developing generic competencies for infrastructure managers in India
Authors: Shah Mona N. , Prakash Anand 
Published: April 2018

Purpose
The purpose of this paper is to develop a model for generic competencies based on lifecycle orientation of projects to support infrastructure managers (IMs) in India.

Design/methodology/approach
This study has reviewed literature on competency theories and their advancement of knowledge in management, construction and engineering projects. This study has applied exploratory factor analysis (EFA) to structure generic competencies founded on infrastructure practices in India. Further this study has applied confirmatory factor analysis (CFA) to test for confirmation on emerged dimensionality of the competence construct for IMs in India.

Findings
Using data collected from 175 usable questionnaires of managers serving in infrastructure firms in India for EFA followed by CFA, six generic competencies have been established in the domains of strategic, analytical, personal, managerial, professional and leadership dimensions significantly impacting competent performance.

Research limitations/implications
This study has applied plausibility sampling and it presents only generic competencies for executives working in the infrastructure sector alone.

Practical implications
Due to the growth in number of executives to be employed in infrastructure firms in India, academic institutions in this subcontinent have gained momentum in offering programmes covering the field of infrastructure management. These institutions are believed to be covering domains of strategic, analytical, personal, managerial, professional and leadership dimensions for assuring competent performance of IMs in India.

Social implications
Attention to these generic competencies can help IMs to contribute towards better performance, academic institutions to design curriculum, recruiters to acquire talent and executives to advance professionally.

Originality/value
Extant academic studies relating to generic competencies are available mostly in project and construction domains. There is a paucity of such academic studies in the domain of infrastructure.
Making sense of interactions between mental health and criminal justice services: the utility of cultural historical activity systems theory
Authors: Hean Sarah , Willumsen Elisabeth , Ødegård Atle 
Published: April 2018

Purpose
Effective collaboration between mental health services (MHS) and criminal justice services (CJS) impacts on mental illness and reduces reoffending rates. This paper proposes the change laboratory model (CLM) of workplace transformation as a potential tool to support interagency collaborative practice that has potential to complement current integration tools used in this context. The purpose of this paper is to focus specifically on the theoretical dimension of the model: the cultural historical activity systems theory (CHAT) as a theoretical perspective that offers a framework with which interactions between the MHS and CJS can be better understood.

Design/methodology/approach
The structure and rationale behind future piloting of the change laboratory in this context is made. Then CHAT theory is briefly introduced and then its utility illustrated in the presentation of the findings of a qualitative study of leaders from MHS and CJS that explored their perspectives of the characteristics of collaborative working between MHS and prison/probation services in a Norwegian context and using CHAT as an analytical framework.

Findings
Leaders suggested that interactions between the two services, within the Norwegian system at least, are most salient when professionals engage in the reintegration and rehabilitation of the offender. Achieving effective communication within the boundary space between the two systems is a focus for professionals engaging in interagency working and this is mediated by a range of integration tools such as coordination plans and interagency meetings. Formalised interagency agreements and informal, unspoken norms of interaction governed this activity. Key challenges limiting the collaboration between the two systems included resource limitations, logistical issues and differences in professional judgments on referral and confidentiality.

Originality/value
Current tools with which MHS/CJS interactions are understood and managed, fail to make explicit the dimensions and nature of these complex interactions. The CLM, and CHAT as its theoretical underpinning, has been highly successful internationally and in other clinical contexts, as a means of exploring and developing interagency working. It is a new idea in prison development, none as yet being applied to the challenges facing the MHS and CJS. This paper addresses this by illustrating the use of CHAT as an analytical framework with which to articulate MHS/CJS collaborations and the potential of the CLM more widely to address current challenges in a context specific, bottom-up and fluid approach to interagency working in this environment.
Creating, reinforcing, and resisting the gender binary: a qualitative study of transgender women’s healthcare experiences in sex-segregated jails and prisons
Authors: White Hughto Jaclyn M. , Clark Kirsty A. , Altice Frederick L. , Reisner Sari L. , Kershaw Trace S. , Pachankis John E. 
Published: April 2018

Purpose
Incarcerated transgender women often require healthcare to meet their physical-, mental-, and gender transition-related health needs; however, their healthcare experiences in prisons and jails and interactions with correctional healthcare providers are understudied. The paper aims to discuss these issues.

Design/methodology/approach
In 2015, 20 transgender women who had been incarcerated in the USA within the past five years participated in semi-structured interviews about their healthcare experiences while incarcerated.

Findings
Participants described an institutional culture in which their feminine identity was not recognized and the ways in which institutional policies acted as a form of structural stigma that created and reinforced the gender binary and restricted access to healthcare. While some participants attributed healthcare barriers to providers’ transgender bias, others attributed barriers to providers’ limited knowledge or inexperience caring for transgender patients. Whether due to institutional (e.g. sex-segregated prisons, biased culture) or interpersonal factors (e.g. biased or inexperienced providers), insufficient access to physical-, mental-, and gender transition-related healthcare negatively impacted participants’ health while incarcerated.

Research limitations/implications
Findings highlight the need for interventions that target multi-level barriers to care in order to improve incarcerated transgender women’s access to quality, gender-affirmative healthcare.

Originality/value
This study provides first-hand accounts of how multi-level forces serve to reinforce the gender binary and negatively impact the health of incarcerated transgender women. Findings also describe incarcerated transgender women’s acts of resistance against institutional and interpersonal efforts to maintain the gender binary and present participant-derived recommendations to improve access to gender affirmative healthcare for incarcerated transgender women.