bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of programmed death‐ligand 1 expression in response to DNA damage in cancer cells: Implications for precision medicine
Authors: Sato Hiro , Jeggo Penny A. , Shibata Atsushi 
Published: September 2019

AbstractAnti‐programmed death‐1 (PD‐1)/programmed death‐ligand 1 (PD‐L1) therapy, which is one of the most promising cancer therapies, is licensed for treating various tumors. Programmed death‐ligand 1, which is expressed on the surface of cancer cells, leads to the inhibition of T lymphocyte activation and immune evasion if it binds to the receptor PD‐1 on CTLs. Anti‐PD‐1/PD‐L1 Abs inhibit interactions between PD‐1 and PD‐L1 to restore antitumor immunity. Although certain patients achieve effective responses to anti‐PD‐1/PD‐L1 therapy, the efficacy of treatment is highly variable. Clinical trials of anti‐PD‐1/PD‐L1 therapy combined with radiotherapy/chemotherapy are underway with suggestive evidence of favorable outcome; however, the molecular mechanism is largely unknown. Among several molecular targets that can influence the efficacy of anti‐PD‐1/PD‐L1 therapy, PD‐L1 expression in tumors is considered to be a critical biomarker because there is a positive correlation between the efficacy of combined treatment protocols and PD‐L1 expression levels. Therefore, understanding the mechanisms underlying the regulation of PD‐L1 expression in cancer cells, particularly the mechanism of PD‐L1 expression following DNA damage, is important. In this review, we consider recent findings on the regulation of PD‐L1 expression in response to DNA damage signaling in cancer cells.
SERCA stimulation: A potential approach in therapeutics
Authors: Rahate Kiran , Bhatt Lokesh Kumar , Prabhavalkar Kedar S. 
Published: September 2019

Abstractsarco–endoplasmic reticulum Ca‐ATPase (SERCA) is the major transporter present in sarco–endoplasmic reticulum (SR/ER), transporting calcium back into SR/ER from cytosol. The calcium‐sequestering activity of SERCA facilitates relaxation in both cardiac and skeletal tissue. ER stress is one of the etiological factors in various diseases such as neurodegenerative diseases and diabetes. Disrupted calcium handling can cause ER stress. In the cardiac tissue, impairment of systolic and diastolic function can cause various cardiovascular diseases. SERCA ensures the proper calcium handling in cells and may act as a therapeutic target for the disease associated with dysregulation of calcium ions. This review examines the principle of calcium ion handling through SERCA and its role in various diseases.
Sanguinarine enhances cisplatin sensitivity via glutathione depletion in cisplatin‐resistant ovarian cancer (A2780) cells
Authors: Sarkhosh‐Inanlou Roya , Molaparast Morteza , Mohammadzadeh Adel , Shafiei‐Irannejad Vahid 
Published: September 2019

AbstractOvarian cancer is considered as one of the most lethal gynecological cancers, and cisplatin‐based therapy has an important role as the first‐line option for chemotherapy. Resistance to chemotherapy is the main obstacle against successful cancer chemotherapy with cisplatin. Therefore, identifying potent compositions and molecules with fewer side‐effects is a big challenge to overcome cisplatin resistance. In this study, we investigated the possible mechanism and potency of sanguinarine, a plant‐derived alkaloid, in human cisplatin‐resistant ovarian cancer (A2780/R) cells. The effect of sanguinarine on cytotoxicity of cisplatin was determined by MTT assay. Apoptosis‐inducing effect of sanguinarine alone and in combination with cisplatin was evaluated by annexin V/PI assay and DAPI staining. Intracellular glutathione (GSH) content was quantitated using GSH assay kit after treatment with sanguinarine. Results indicated that sanguinarine enhances the sensitivity of A2780/R cells to cisplatin. Apoptosis‐inducing effect of cisplatin was also enhanced when combined with sanguinarine. Furthermore, sanguinarine reduced intracellular GSH content in a dose‐dependent but not time‐dependent manner. These findings suggest that sanguinarine could reverse cisplatin resistance in A2780/R cells through GSH reduction. Therefore, sanguinarine can be used as one of the potent adjuvants for ovarian cancer chemotherapy.
Risk indicators for root caries in older adults using long‐term social care facilities in Hong Kong
Authors: Zhang Jingyang , Leung Katherine C. M. , Chu Chun H. , Lo Edward C. M. 
Published: September 2019

AbstractObjectiveTo investigate risk indicators associated with root caries among the Hong Kong older adults who attended long‐term care facilities regularly.MethodsNonfrail older adults with at least six natural teeth from 10 long‐term social or residential care facilities were examined. The clinical examinations were conducted by two calibrated dentists in the institutions. Portal dental chairs, intra‐oral LED lights, disposable mouth mirrors, periodontal probes and CPI probes were used in the examinations. Negative binomial regression analyses were performed to identify the risk indicators associated with root caries. Multilevel logistic regression analyses were conducted to detect the associations between DF‐root and D‐root, and selected person‐level and tooth surface‐level factors.ResultsA total of 353 older adults (mean age 74.9 years) were examined. The prevalence of DF‐root and D‐root was 43.1% and 30.0%, respectively. The mean DF‐root and D‐root scores were 1.3 and 0.7, respectively. Relative to participants without DF‐root, those with root caries experience were older and had more exposed root surfaces, and a higher proportion were partial denture wearers. There was a positive correlation between the DF‐root score and the age of the participant, and with the numbers of exposed root surfaces, missing teeth and teeth with coronal caries. Higher prevalence of DF‐root was observed among the older participants, and caries experience of root surfaces with greater gingival recession and visible plaque was higher. Lingual root surfaces and roots in the mandibular anterior region had the lowest rates of DF‐root.ConclusionsPeople who are older have a higher prevalence and severity of root caries. Coronal caries experience, maxillary teeth, buccal root surfaces, gingival recession and plaque on the root surface are positively associated with root caries in older adults.
Manual Movement in Sign Languages: One Hand Versus Two in Communicating Shapes
Authors: Ferrara Casey , Napoli Donna Jo 
Published: September 2019

AbstractIn sign languages, the task of communicating a shape involves drawing in the air with one moving hand (Method One) or two (Method Two). Since the movement path is iconic, method choice might be based on the shape. In the present studies we aimed to determine whether geometric properties motivate method choice. In a study of 17 deaf signers from six countries, the strongest predictors of method choice were whether the shape has any curved edges (Method One), and whether the shape is symmetrical across the Y‐axis (Method Two), where the default was Method One. In a second study of ASL dictionary entries for which the movement path of the sign is iconic of an entity's shape, the same predictors surfaced. These tendencies are captured in the Lexical Drawing Principle, which is coherent with biological constraints on movement in general. Drawing in the air with two hands, however, is costly, both cognitively and biomechanically. Furthermore, it distinguishes signers from non‐signers, who draw shapes with only one hand. Signers assume this extra cost in the lexicon because of the enhanced iconicity the possibility of two hands offers; they assume it in drawing shapes in the air because they apply the same linguistic principle they use in the lexicon. Additionally, having a choice of methods allows the signer to benefit from over‐specification in providing redundant information about the shape, enhancing comprehensibility and resolving ambiguity.
Thematic analysis of youth mental health providers' perceptions of neuropsychological assessment services
Authors: Delagneau Garance , Bowden Stephen C. , Bryce Shayden , van‐der‐EL Kristi , Hamilton Matthew , Adams Sophie , Burgat Liz , Killackey Eoin , Rickwood Debra , Allott Kelly 
Published: September 2019

AbstractAimA growing number of quantitative studies have investigated the utility of neuropsychological assessment in mental health settings. However, to the best of our knowledge, no previous study has qualitatively explored youth mental health providers' perceptions of neuropsychological assessment services. A more in‐depth understanding of the perceived advantages and barriers associated with neuropsychological assessment in youth mental health settings is critical to better inform policy, practice and service uptake. Thus, the aim of this study was to qualitatively explore clinicians' views about neuropsychological assessments for youth with mental health concerns.MethodsA single open‐ended qualitative question, included as part of an anonymous cross‐sectional online survey, was completed by clinicians (N = 206) treating or assessing adolescents and young adults within Australian primary care mental health centres (headspace). Responses were analysed using an inductive approach to thematic analysis.ResultsFive main themes were identified. Clinicians (a) identified barriers to accessing neuropsychological assessments (53%), (b) indicated a range of mixed outcomes following neuropsychological assessment (39%), (c) highlighted a need for neuropsychological assessments (22%), (d) reported a lack of awareness about this resource (10%) and (e) described practice issues associated with neuropsychological services (4%).ConclusionThis study uncovered perceived factors contributing to reduced access to neuropsychological assessment in Australian youth mental health settings. Given potential adverse outcomes resulting from this clinical service gap, efforts should be made to address factors contributing to poorer access, thereby mitigating the impact of poor access on the management of mental illness in youth. Several strategies, including funding neuropsychological assessments, are discussed.
Cytogenetic landscape in 1012 newly diagnosed chronic lymphocytic leukemia
Authors: Senouci Amel , Smol Thomas , Tricot Sabine , Bakala Jania , Moulessehoul Soraya , Quilichini Benoît , Penther Dominique , Herbaux Charles , Daudignon Agnès 
Published: September 2019

AbstractBackgroundChronic lymphocytic leukemia (CLL) stratification mainly relies on FISH markers according to Döhner's hierarchical model which includes high‐risk FISH markers, intermediate FISH, or low‐risk FISH. Recently, complex karyotype (CK) has been demonstrated as an independent negative prognostic factor in CLL.MethodsA series of 1012 untreated CLL patients have been investigated with both FISH and chromosome banding analysis (CBA) on the same pellet obtained from interleukin IL‐2‐CPG DSP30 oligonucleotide‐stimulated cultured cells.ResultsCombining both FISH and CBA has led to refine prognostic categories with identification of 30% of CK in low‐risk and intermediate FISH group. This raises the issue of switching them to a high‐risk group. While this series confirmed the significant association between CK and high‐risk FISH (P = .003), 33% of CK present no ATM or TP53 deletion. Three groups characterized by significant association between FISH markers and CBA have emerged: CK with TP53 loss and monosomy 15; CK with ATM loss and 14q32 translocation; and CK without ATM or TP53 losses but trisomies 12, 18, and 19 or t(14;18)(q32;q21).ConclusionWe have observed that in addition to FISH analysis, the CBA allows detection of many abnormalities with potential impact on patient follow‐up and treatment, mainly CK.
Estimating the mineral surface area of soils by measured water adsorption. Adjusting for the confounding effect of water adsorption by soil organic carbon
Authors: Kirschbaum Miko U.F. , Giltrap Donna L. , McNally Sam R. , Liáng Lìyǐn L. , Hedley Carolyn B. , Moinet Gabriel Y.K. , Blaschek Michael , Beare Michael H. , Theng Benny K.G. , Hunt John E. , Whitehead David 
Published: September 2019

AbstractSpecific surface area can be a strong predictor of organic carbon (SOC) contents in soils. Specific surface area can be estimated reliably and cost‐effectively from water adsorption by air‐dry soil samples, but SOC itself can also adsorb water. For estimating the mineral component of specific surface area, it is, therefore, necessary to exclude water‐adsorption by SOC. Here, we refer to “apparent specific surface area” for measurements that include water adsorption by both mineral soil and SOC. We used a mathematical approach to estimate water adsorption by SOC so that this component can be subtracted from measurements of apparent specific surface area.We used a dataset of apparent specific surface area and soil carbon at seven depths from 50 soil cores collected from a research farm in the Manawatu region in New Zealand. Both apparent specific surface area and SOC content decreased with soil depth with very high correlation (r2 = 0.98). We estimated the SOC contribution to apparent specific surface area from the slope of the relationship between changes in apparent specific surface area and SOC content. For our soils, the SOC contribution to apparent specific surface area was estimated as 0.43 ± 0.02 m2 mgC−1. This parameter allows apparent specific surface area measurements to be corrected for the water adsorption by SOC to calculate the functionally relevant mineral specific surface area.Highlights
Soil surface area can be estimated from the H2O content of air‐dry soil but SOC also adsorbs H2O.
We developed a mathematical approach to estimate water adsorption by SOC.
We estimated the contribution of SOC to apparent specific surface area as 0.43 ± 0.02 m2 mgC−1.
Mineral specific surface area can be inferred by subtracting SOC‐based H2O adsorption.
Red Sea corals under Artificial Light Pollution at Night (ALAN) undergo oxidative stress and photosynthetic impairment
Authors: Ayalon Inbal , de Barros Marangoni Laura F. , Benichou Jennifer I. C. , Avisar Dror , Levy Oren 
Published: September 2019

AbstractCoral reefs represent the most diverse marine ecosystem on the planet, yet they are undergoing an unprecedented decline due to a combination of increasing global and local stressors. Despite the wealth of research investigating these stressors, Artificial Light Pollution at Night (ALAN) or “ecological light pollution” represents an emerging threat that has received little attention in the context of coral reefs, despite the potential of disrupting the chronobiology, physiology, behavior, and other biological processes of coral reef organisms. Scleractinian corals, the framework builders of coral reefs, depend on lunar illumination cues to synchronize their biological rhythms such as behavior, reproduction and physiology. While, light pollution (POL) may mask and lead de‐synchronization of these biological rhythms process. To reveal if ALAN impacts coral physiology, we have studied two coral species, Acropora eurystoma and Pocillopora damicornis, from the Gulf of Eilat/Aqaba, Red Sea, which is undergoing urban development that has led to severe POL at night. Our two experimental design data revealed that corals exposed to ALAN face an oxidative stress condition, show lower photosynthesis performances measured by electron transport rate (ETR), as well as changes in chlorophyll and algae density parameters. Testing different lights such as Blue LED and White LED spectrum showed more extreme impact in comparison to Yellow LEDs on coral physiology. The finding of this work sheds light on the emerging threat of POL and the impacts on the biology and ecology of Scleractinian corals, and will help to formulate specific management implementations to mitigate its potentially harmful impacts.
Post‐grazing cutting management in tall fescue affects the sward structure, forage and liveweight production
Authors: Scheneiter Jorge Omar , Camarasa Jonatan Nicolás , Aperlo Daniel , Ferrari Martín Alejandro , Nalino Martín , Beribe María J. 
Published: September 2019

AbstractTall fescue is the main perennial grass of the pastures of the temperate region of Argentina. However, after flowering in spring, tall fescue loses productivity and quality. Based on this, the objective of this work was to evaluate the effects of different post‐grazing mechanical cutting managements on the forage mass, leaf proportion, stocking rate, liveweight gain and liveweight production of tall fescue pastures. The treatments were post‐grazing mechanical cutting at anthesis (FC), post‐grazing mechanical cutting throughout spring and summer (SSC), and no post‐grazing mechanical cutting (NC). The experiment was performed from 2011 to 2014 in Argentina. The greatest and lowest forage mass were determined in September–November and May–September respectively. The leaf proportion of the SSC treatment was greater than that of the NC treatment, except in September–November. NC had higher stocking rate and lower liveweight gain than SSC, and neither NC nor SSC differed from FC. The liveweight production of the treatments was characterized by a trade‐off between stocking rate and liveweight gain. We conclude that FC is an attractive management because, with a single post‐grazing cutting, swards remain productive and leafy.
Automated Analyte Separation by Ion Chromatography Using a Cobot Applied to Geological Reference Materials for Li Isotope Composition
Authors: Kuessner Marie L. , Gourgiotis Alkiviadis , Manhès Gerard , Bouchez Julien , Zhang Xu , Gaillardet Jérôme 
Published: September 2019

The demand for large and reliable data sets on isotopic composition has increased in geochemistry and environmental sciences over recent years. We present an automated ion chromatographic separation method using a robotic pipetting arm, termed ‘ChemCobOne’, to reduce sample separation time. Its performance was tested for lithium isotope separation in geological reference materials using a single‐step separation with HCl (0.2 mol l−1) and a 2 ml resin volume. This refined lithium purification method does not forfeit precision, accuracy or purity compared with manual sample processing. In addition, a δ7Li value for NASS‐6 of 30.99 ± 0.50‰ (2s) (95% CI = 0.14‰, n = 44) was determined and the first δ7Li values for the granite rock reference material GS‐N (−0.57 ± 0.25‰ (2s), 95% CI = 0.15‰, n = 15), and for the soil reference material NIST SRM 2709a (−0.37 ± 0.67‰ (2s), 95% CI = 0.15‰, n = 63) are proposed.
Development and content validation of the Telenursing Interaction and Satisfaction Questionnaire (TISQ)
Authors: Mattisson Marie , Johnson Christina , Börjeson Sussanne , Årestedt Kristofer , Lindberg Malou 
Published: September 2019

AbstractBackgroundCaller satisfaction with telephone advice nursing (TAN) is generally high, and the interaction is essential. However, a valid questionnaire exploring caller satisfaction in TAN with focus on perceived interaction is lacking.ObjectiveTo develop and assess content validity and test‐retest reliability of a theoretically anchored questionnaire, the Telenursing Interaction and Satisfaction Questionnaire (TISQ), that explores caller satisfaction in TAN by focusing on perceived interaction between the caller and the telenurse.MethodsThe study was performed in three stages. First, variables relevant for patient satisfaction in health care were identified through a literature search. Variables were then structured according to the Interaction Model of Client Health Behavior (IMCHB), which provided theoretical guidance. Items relevant for a TAN context were developed through consensus discussions. Then, evaluation and refinement were performed through cognitive interviews with callers and expert ratings of the Content Validity Index (CVI). Finally, test‐retest reliability of items was evaluated in a sample of 109 individuals using intraclass correlation coefficients (ICC).ResultsThe TISQ consists of 60 items. Twenty items cover perceived interaction in terms of health information, affective support, decisional control and professional/technical competence. Five items cover satisfaction with interaction and five items overall satisfaction. Remaining items reflect singularity of the caller and descriptive items of the call. The TISQ was found to exhibit good content validity, and test‐retest reliability was moderate to good (ICC = 0.39‐0.84).ConclusionsThe items in the TISQ form a comprehensive and theoretically anchored questionnaire with satisfactory content validity and test‐retest reliability.
Influence of surface oxide layer of SiC powder on the rheological properties of its slurry
Authors: Gao Xiaoying , Wang Ruiyu , Zhao Juan , Huang Junxiao , Gao Yuan , Liu Huitao 
Published: September 2019

AbstractIn this paper, the influence of surface oxide layer of SiC powder on the rheological behavior of its slurry was studied by acid washing, HF etching, and calcination oxidation processes. Zeta potential, particle size, inductively coupled plasma atomic emission spectrometry (ICP‐AES), energy dispersive X‐ray spectroscopy, and viscosity tests indicated the main factor that resulted in high viscosity of slurry is impure ions existing either on the powder surface or in the water phase, rather than the surface oxide layer. After the impure ions are removed, the surface oxide layer formed at a calcination temperature range of 400°C‐750°C does not cause an increase in the slurry viscosity, but contributes to an improvement in the rheological properties of SiC slurry.
Willingness to pay for family education and counselling services provided by critical care advanced practice nurses
Authors: Ko Chung Mee , Koh Chin Kang , Kwon Sangho 
Published: September 2019

AbstractAimThe aim of this study was to estimate the economic value of a family education and counselling service provided by critical care advanced practice nurses in South Korea utilizing a contingent valuation approach.MethodsA double‐bounded dichotomous choice contingent valuation method was utilized to estimate the public's willingness to pay value for an education and counselling service provided by critical care advanced practice nurses. A web‐based self‐administered survey was conducted.ResultsMedian willingness to pay was 43 112 Korean won (35 US dollars). Higher income and younger age were associated with higher willingness to pay.ConclusionThis study captured the economic value of an education and counselling service provided by critical care advanced practice nurses that is not on the benefit list under the fee‐for‐service system of the Korean National Health System. Policy makers should consider including such services in the health care system.