bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of integrated disease management in high-risk COPD patients in primary care
Authors: Ferrone Madonna , Masciantonio Marcello G. , Malus Natalie , Stitt Larry , O’Callahan Tim , Roberts Zofe , Johnson Laura , Samson Jim , Durocher Lisa , Ferrari Mark , Reilly Margo , Griffiths Kelly , Licskai Christopher J. ,   The Primary Care Innovation Collaborative, Atkins Andrew , Baker Bill , Dalo Sara , Piccinato Jean , Waddick Denise , Wong Brice 
Published: March 2019

AbstractPatients with chronic obstructive pulmonary disease (COPD) have a reduced quality of life (QoL) and exacerbations that drive health service utilization (HSU). A majority of patients with COPD are managed in primary care. Our objective was to evaluate an integrated disease management, self-management, and structured follow-up intervention (IDM) for high-risk patients with COPD in primary care. This was a one-year multi-center randomized controlled trial. High-risk, exacerbation-prone COPD patients were randomized to IDM provided by a certified respiratory educator and physician, or usual physician care. IDM received case management, self-management education, and skills training. The primary outcome, COPD-related QoL, was measured using the COPD Assessment Test (CAT). Of 180 patients randomized from 8 sites, 81.1% completed the study. Patients were 53.6% women, mean age 68.2 years, post-bronchodilator FEV1 52.8% predicted, and 77.4% were Global Initiative for Obstructive Lung Disease Stage D. QoL-CAT scores improved in IDM patients, 22.6 to 14.8, and worsened in usual care, 19.3 to 22.0, adjusted difference 9.3 (p < 0.001). Secondary outcomes including the Clinical COPD Questionnaire, Bristol Knowledge Questionnaire, and FEV1 demonstrated differential improvements in favor of IDM of 1.29 (p < 0.001), 29.6% (p < 0.001), and 100 mL, respectively (p = 0.016). Compared to usual care, significantly fewer IDM patients had a severe exacerbation, −48.9% (p < 0.001), required an urgent primary care visit for COPD, −30.2% (p < 0.001), or had an emergency department visit, −23.6% (p = 0.001). We conclude that IDM self-management and structured follow-up substantially improved QoL, knowledge, FEV1, reduced severe exacerbations, and HSU, in a high-risk primary care COPD population. Clinicaltrials.gov NCT02343055.
Dogs demonstrate the existence of an epileptic seizure odour in humans
Authors: Catala Amélie , Grandgeorge Marine , Schaff Jean-Luc , Cousillas Hugo , Hausberger Martine , Cattet Jennifer 
Published: March 2019

AbstractAlthough different studies have shown that diseases such as breast or lung cancer are associated with specific bodily odours, no study has yet tested the possibility that epileptic seizures may be reflected in an olfactory profile, probably because there is a large variety of seizure types. The question is whether a “seizure-odour”, that would be transversal to individuals and types of seizures, exists. This would be a pre requisite for potential anticipation, either by electronic systems (e.g., e-noses) or trained dogs. The aim of the present study therefore was to test whether trained dogs, as demonstrated for cancer or diabetes, may discriminate a general epileptic seizure odor (different from body odours of the same person in other contexts and common to different persons). The results were very clear: all dogs discriminated the seizure odour. The sensitivity and specificity obtained were amongst the highest shown up to now for discrimination of diseases. This constitutes a first proof that, despite the variety of seizures and individual odours, seizures are associated with olfactory characteristics. These results open a large field of research on the odour signature of seizures. Further studies will aim to look at potential applications in terms of anticipation of seizures.
A novel flow-based geometrical upscaling method to represent three-dimensional complex sub-seismic fault zone structures into a dynamic reservoir model
Authors: Islam Md Saiful , Manzocchi Tom 
Published: March 2019

AbstractMost hydrocarbon reservoirs contain faults, which are highly complex heterogeneous and anisotropic three-dimensional (3D) volumes of deformed rock. A major technical challenge in full-field flow simulation is to represent the effects of 3D fault zone structure within the two-dimensional (2D) fault planar surfaces using the industry standard commercial reservoir flow simulator due to its limited functionality. Therefore, a new flow-based geometrical upscaling (FBGU) method has been developed for capturing the effects of 3D fault zone structures in conventional low-resolution upscaled flow simulation models. Geometrical upscaling (GU) is the process of calculating across-fault and up-fault transmissibility arising from 3D flow paths through fault zones, and expressing these transmissibilities as implicit connections in a low-resolution upscaled flow simulation model. The high accuracy of the method is demonstrated by comparing the flow responses of high-resolution (referred as truth model in this paper) simulation models in which the 3D fault zone structure is represented explicitly in the grid geometry, with that of conventional resolution models in which it is upscaled using FBGU method. The flow results show that the newly developed FBGU method is extremely accurate and geometrically flexible.
Breast cancer occurrence after low dose radiotherapy of non-malignant disorders of the shoulder
Authors: Zwicker Felix , Kirchner Corinna , Huber Peter E. , Debus Jürgen , Zwicker Hansjörg , Klepper Rudolf 
Published: March 2019

AbstractStochastic long-term damages at relatively low doses have the potential for cancer induction. For the first time we investigated the occurrence of breast cancer in female patients after radiotherapy of non-malignant disorders of the shoulder and made a comparison with the estimated spontaneous incidence of mammary carcinoma for this cohort. In a geographically defined district with a population of approximately 100.000 inhabitants, comprehensive data of radiological diagnostics and radiotherapy were registered nearly completely for 41 years; data included mammography and radiotherapy of breast cancer patients as well as of non-malignant disorders. Within this population a collective of 158 women with radiotherapy of the shoulder was investigated. Radiotherapy was performed with cobalt-60 photons (Gammatron) with an average cumulative-dose of 6 Gy. The average follow-up time was 21.3 years. Patients were 55 years old (median) when radiotherapy of the shoulder was performed. Seven patients (4.4%) developed breast cancer after a median of 21 years. According to the incidence statistics, 9.4 +/− 1.8 (95%CI) cases (5.9%) would be expected. In regard to the irradiated shoulder neither the ipsilateral nor the contralateral breasts showed increased rates of breast cancer. An induction of additional breast cancer caused by radiation of non-malignant disorders of the shoulder wasn’t detected in the investigated cohort.
Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation
Authors: Jiang Yi , Luo Yongfeng , Tang Yang , Moats Rex , Warburton David , Zhou Shengmei , Lou Jianlin , Pryhuber Gloria S. , Shi Wei , Wang Larry L. 
Published: March 2019

AbstractCongenital pulmonary airway malformation (CPAM) is the most common congenital lesion detected in the neonatal lung, which may lead to respiratory distress, infection, and pneumothorax. CPAM is thought to result from abnormal branching morphogenesis during fetal lung development, arising from different locations within the developing respiratory tract. However, the pathogenic mechanisms are unknown, and previous studies have focused on abnormalities in airway epithelial cells. We have analyzed 13 excised lung specimens from infants (age < 1 year) with a confirmed diagnosis of type 2 CPAM, which is supposed to be derived from abnormal growth of intrapulmonary distal airways. By examining the mesenchymal components including smooth muscle cells, laminin, and elastin in airway and cystic walls using immunofluorescence staining, we found that the thickness and area of the smooth muscle layer underlining the airway cysts in these CPAM tissue sections were significantly decreased compared with those in bronchiolar walls of normal controls. Extracellular elastin fibers were also visually reduced or absent in airway cystic walls. In particular, a layer of elastin fibers seen in normal lung between airway epithelia and underlying smooth muscle cells was missing in type 2 CPAM samples. Thus, our data demonstrate for the first time that airway cystic lesions in type 2 CPAM occur not only in airway epithelial cells, but also in adjacent mesenchymal tissues, including airway smooth muscle cells and their extracellular protein products. This provides a new direction to study the molecular and cellular mechanisms of CPAM pathogenesis in human.
Single-cell assessment of transcriptome alterations induced by Scriptaid in early differentiated human haematopoietic progenitors during ex vivo expansion
Authors: Hua Peng , Kronsteiner Barbara , van der Garde Mark , Ashley Neil , Hernandez Diana , Tarunina Marina , Hook Lilian , Choo Yen , Roberts Irene , Mead Adam , Watt Suzanne M. 
Published: March 2019

AbstractPriming haematopoietic stem/progenitor cells (HSPCs) in vitro with specific chromatin modifying agents and cytokines under serum-free-conditions significantly enhances engraftable HSC numbers. We extend these studies by culturing human CD133+ HSPCs on nanofibre scaffolds to mimic the niche for 5-days with the HDAC inhibitor Scriptaid and cytokines. Scriptaid increases absolute Lin−CD34+CD38−CD45RA−CD90+CD49f+ HSPC numbers, while concomitantly decreasing the Lin−CD38−CD34+CD45RA−CD90− subset. Hypothesising that Scriptaid plus cytokines expands the CD90+ subset without differentiation and upregulates CD90 on CD90− cells, we sorted, then cultured Lin−CD34+CD38−CD45RA−CD90− cells with Scriptaid and cytokines. Within 2-days and for at least 5-days, most CD90− cells became CD90+. There was no significant difference in the transcriptomic profile, by RNAsequencing, between cytokine-expanded and purified Lin−CD34+CD38−CD45RA−CD49f+CD90+ cells in the presence or absence of Scriptaid, suggesting that Scriptaid maintains stem cell gene expression programs despite expansion in HSC numbers. Supporting this, 50 genes were significantly differentially expressed between CD90+ and CD90− Lin−CD34+CD38−CD45RA−CD49f+ subsets in Scriptaid-cytokine- and cytokine only-expansion conditions. Thus, Scriptaid treatment of CD133+ cells may be a useful approach to expanding the absolute number of CD90+ HSC, without losing their stem cell characteristics, both through direct effects on HSC and potentially also conversion of their immediate CD90− progeny into CD90+ HSC.
Automated classification platform for the identification of otitis media using optical coherence tomography
Authors: Monroy Guillermo L. , Won Jungeun , Dsouza Roshan , Pande Paritosh , Hill Malcolm C. , Porter Ryan G. , Novak Michael A. , Spillman Darold R. , Boppart Stephen A. 
Published: March 2019

AbstractThe diagnosis and treatment of otitis media (OM), a common childhood infection, is a significant burden on the healthcare system. Diagnosis relies on observer experience via otoscopy, although for non-specialists or inexperienced users, accurate diagnosis can be difficult. In past studies, optical coherence tomography (OCT) has been used to quantitatively characterize disease states of OM, although with the involvement of experts to interpret and correlate image-based indicators of infection with clinical information. In this paper, a flexible and comprehensive framework is presented that automatically extracts features from OCT images, classifies data, and presents clinically relevant results in a user-friendly platform suitable for point-of-care and primary care settings. This framework was used to test the discrimination between OCT images of normal controls, ears with biofilms, and ears with biofilms and middle ear fluid (effusion). Predicted future performance of this classification platform returned promising results (90%+ accuracy) in various initial tests. With integration into patient healthcare workflow, users of all levels of medical experience may be able to collect OCT data and accurately identify the presence of middle ear fluid and/or biofilms.
Changes in hepatic metabolic profile during the evolution of STZ-induced diabetic rats via an 1H NMR-based metabonomic investigation
Authors: Chen Minjiang , Zheng Hong , Xu Min , Zhao Liangcai , Zhang Qianqian , Song Jingjing , Zhao Zhongwei , Lu Siming , Weng Qiaoyou , Wu Xulu , Yang Weibin , Fan Xiaoxi , Gao Hongchang , Ji Jiansong 
Published: March 2019

Abstract
Background: The present study aimed to explore the changes in the hepatic metabolic profile during the evolution of diabetes mellitus (DM) and verify the key metabolic pathways. Methods: Liver samples were collected from diabetic rats induced by streptozotocin (STZ) and rats in the control group at 1, 5, and 9 weeks after STZ administration. Proton nuclear magnetic resonance spectroscopy (1H NMR)-based metabolomics was used to examine the metabolic changes during the evolution of DM, and partial least squares-discriminate analysis (PLS-DA) was performed to identify the key metabolites. Results: We identified 40 metabolites in the 1H NMR spectra, and 11 metabolites were further selected by PLS-DA model. The levels of α-glucose and β-glucose, which are two energy-related metabolites, gradually increased over time in the DM rats, and were significantly greater than those of the control rats at the three-time points. The levels of choline, betaine, and methionine decreased in the DM livers, indicating that the protective function in response to liver injury may be undermined by hyperglycemia. The levels of the other amino acids (leucine, alanine, glycine, tyrosine, and phenylalanine) were significantly less than those of the control group during DM development. Conclusions: Our results suggested that the hepatic metabolic pathways of glucose, choline-betaine-methionine, and amino acids were disturbed during the evolution of diabetes, and that choline-betaine-methionine metabolism may play a key role.
P66Shc and vascular endothelial function
Authors: Kumar Santosh 
Published: March 2019

Abstract
Dysfunctional endothelium is an early change in vasculature known to be associated with atherosclerosis. Among many regulators of vascular endothelial function, p66Shc has consistently been shown to mediate endothelial dysfunction. Over more than three decades of active research in the field of the physiological function of p66Shc, regulation of vascular endothelial functions has emerged as one of the most robust effects in a broad range of pathological conditions including hyperlipidemia, diabetes, and aging. A significant understanding has been developed with respect to the molecular signaling regulating the oxidative function of p66Shc in endothelial cells and its targets and regulators. In addition, novel regulatory modifications of p66Shc controlling its oxidative function, subcellular distribution, and stability have also been reported. This review will focus on summarizing the molecular signaling regulating the oxidative function of p66Shc and its role in vascular endothelium.
Linguistic Contributions to Word-Level Spelling Accuracy in Elementary School Children With and Without Specific Language Impairment
Authors: Werfel Krystal L. , Melanie Schuele C. , Reed Paul 
Published: March 2019

Purpose
Children with specific language impairment (SLI) are more likely than children with typical language (TL) to exhibit difficulties in word-level spelling accuracy. More research is needed to elucidate the contribution of linguistic knowledge to word-level spelling accuracy in this population. The purpose of this study was to explore the contributions of linguistic knowledge to spelling accuracy in a group of 2nd- to 4th-grade children with SLI and a group of 2nd- to 4th-grade children with TL.

Method
Participants were 32 children with SLI and 32 children with TL in Grades 2 through 4. Five areas of linguistic knowledge were assessed: phonological awareness, morphological knowledge, orthographic pattern knowledge, mental grapheme representation knowledge, and vocabulary knowledge. Mixed-effects logistic regression models were utilized to address the research aim.

Results
Mental grapheme representation knowledge was selected as a significant predictor in both models; however, phonological awareness was the only additional significant predictor in the model for children with SLI, whereas morphological knowledge was the only other significant predictor in the model for children with TL. Orthographic pattern knowledge and vocabulary knowledge were not significant for either group.

Conclusions
The results suggest that spelling instruction and intervention for children with SLI should take linguistic knowledge into account and explicitly relate linguistic knowledge to spelling. Additionally, future research should consider if instructional targets for children with SLI should differ from targets for children with TL and if these findings represent a delay or a disorder in spelling acquisition for children with SLI.
Mapping the stellar age of the Milky Way bulge with the VVV
Authors: Surot F. , Valenti E. , Hidalgo S. L. , Zoccali M. , Sökmen E. , Rejkuba M. , Minniti D. , Gonzalez O. A. , Cassisi S. , Renzini A. , Weiss A. 
Published: March 2019

Context. Recent observational programs are providing a global view of the Milky Way bulge that serves as a template for detailed comparison with models and extragalactic bulges. A number of surveys (VVV, GIBS, GES, ARGOS, BRAVA, APOGEE) are producing comprehensive and detailed extinction, metallicity, kinematics, and stellar density maps of the Galactic bulge with unprecedented accuracy. However, the still missing key ingredient is the distribution of stellar ages across the bulge.
Aims. To overcome this limitation, we aim to age-date the stellar population in several bulge fields with the ultimate goal of deriving an age map of the bulge. This paper presents the methodology and the first results obtained for a field along the bulge minor axis, at b = −6°.
Methods. We use a new PSF-fitting photometry of the VISTA Variables in the Vía Láctea (VVV) survey data to construct deep color–magnitude diagrams of the bulge stellar population down to ∼2 mag below the main sequence turnoff. To address the contamination by foreground disk stars we adopt a statistical approach by using control-disk fields located at different latitudes (spanning approximately the bulge’s range) and longitudes −30° and +20°. We generate synthetic photometric catalogs of complex stellar populations with different age and metallicity distributions, including the observational errors and completeness. The comparison between the color–magnitude diagrams of synthetic and observed disk-decontaminated bulge populations provides constraints on the stellar ages in the observed field.
Results. We find the bulk of the bulge stellar population in the observed field along the minor axis to be older than ∼7.5 Gyr. In particular, when the metallicity distribution function spectroscopically derived by GIBS is used, the best fit to the data is obtained with a combination of synthetic populations with ages in between ∼7.5 Gyr and 11 Gyr. However, the fraction of stars younger than ∼10 Gyr strongly depends upon the number of blue straggler stars present in the bulge. Simulations show that the observed color–magnitude diagram of the bulge in the field along the minor axis is incompatible with the presence of a conspicuous population of intermediate-age and young (≲5 Gyr) stars.
Hint of curvature in the orbital motion of the exoplanet 51 Eridani b using 3 yr of VLT/SPHERE monitoring
Authors: Maire A.-L. , Rodet L. , Cantalloube F. , Galicher R. , Brandner W. , Messina S. , Lazzoni C. , Mesa D. , Melnick D. , Carson J. , Samland M. , Biller B. A. , Boccaletti A. , Wahhaj Z. , Beust H. , Bonnefoy M. , Chauvin G. , Desidera S. , Langlois M. , Henning T. , Janson M. , Olofsson J. , Rouan D. , Ménard F. , Lagrange A.-M. , Gratton R. , Vigan A. , Meyer M. R. , Cheetham A. , Beuzit J.-L. , Dohlen K. , Avenhaus H. , Bonavita M. , Claudi R. , Cudel M. , Daemgen S. , D’Orazi V. , Fontanive C. , Hagelberg J. , Le Coroller H. , Perrot C. , Rickman E. , Schmidt T. , Sissa E. , Udry S. , Zurlo A. , Abe L. , Origné A. , Rigal F. , Rousset G. , Roux A. , Weber L. 
Published: March 2019

Context. The 51 Eridani system harbors a complex architecture with its primary star forming a hierarchical system with the binary GJ 3305AB at a projected separation of 2000 au, a giant planet orbiting the primary star at 13 au, and a low-mass debris disk around the primary star with possible cold and warm components inferred from the spectral energy distribution.
Aims. We aim to better constrain the orbital parameters of the known giant planet.
Methods. We monitored the system over three years from 2015 to 2018 with the Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) instrument at the Very Large Telescope (VLT).
Results. We measure an orbital motion for the planet of ~130 mas with a slightly decreasing separation (~10 mas) and find a hint of curvature. This potential curvature is further supported at 3σ significance when including literature Gemini Planet Imager (GPI) astrometry corrected for calibration systematics. Fits of the SPHERE and GPI data using three complementary approaches provide broadly similar results. The data suggest an orbital period of 32−9+17 yr (i.e., 12−2+4 au in semi-major axis), an inclination of 133−7+14 deg, an eccentricity of 0.45−0.15+0.10, and an argument of periastron passage of 87−30+34 deg [mod 180°]. The time at periastron passage and the longitude of node exhibit bimodal distributions because we do not yet detect whether the planet is accelerating or decelerating along its orbit. Given the inclinations of the orbit and of the stellar rotation axis (134–144°), we infer alignment or misalignment within 18° for the star–planet spin-orbit. Further astrometric monitoring in the next 3–4 yr is required to confirm at a higher significance the curvature in the motion of the planet, determine if the planet is accelerating or decelerating on its orbit, and further constrain its orbital parameters and the star–planet spin-orbit.