bluuebunny/crossref_metadata_2025_split huggingface dataset:
ВРАЩЕНИЕ БЛОКОВ ЗЕМНОЙ КОРЫ МЕЖДУ СДВИГОВЫМИ ЗОНАМИ НИЖНЕГО ПРИАМУРЬЯ (ПО МОРФОСТРУКТУРНЫМ ДАННЫМ), "Геоморфология"
Authors: ОБУХОВ Ф.С. , Меркулова Т.В. 
Published: September 2018

По структурно-геоморфологическим данным в Нижнем Приамурье выделен геоблок (структурный элемент первого порядка Амурской плиты), который находится под влиянием неотектонических правосторонних сдвиговых смещений по трансрегиональным разломам северо-восточного простирания. Под воздействием напряжений внутри геоблока сформированы дуговые разломы, геоморфологически выраженные сопряженной системой речных долин, которые ограничивают четыре блока округлого габитуса, сложенных магматическими образованиями и складчатыми осадочными породами мезо-кайнозойского возраста. Вихреобразное расположение разломов внутри блоков и правосторонние латеральные смещениям по ним, согласно направлению деформаций по северо-восточным разломам, указывают на вращение этих блоков против часовой стрелки.
Bidirectional Risk Modulator and Modifier Variant of Dilated and Hypertrophic Cardiomyopathy in BAG3
Authors: Park Joseph , Levin Michael G. , Zhang David , Reza Nosheen , Mead Jonathan O. , Carruth Eric D. , Kelly Melissa A. , Winters Alex , Kripke Colleen M. , Judy Renae L. , Damrauer Scott M. , Owens Anjali T. , Bastarache Lisa , Verma Anurag , Kinnamon Daniel D. , Hershberger Ray E. , Ritchie Marylyn D. , Rader Daniel J. 
Published: November 2024

ImportanceThe genetic factors that modulate the reduced penetrance and variable expressivity of heritable dilated cardiomyopathy (DCM) are largely unknown. BAG3 genetic variants have been implicated in both DCM and hypertrophic cardiomyopathy (HCM), nominating BAG3 as a gene that harbors potential modifier variants in DCM.ObjectiveTo interrogate the clinical traits and diseases associated with BAG3 coding variation.Design, Setting, and ParticipantsThis was a cross-sectional study in the Penn Medicine BioBank (PMBB) enrolling patients of the University of Pennsylvania Health System’s clinical practice sites from 2014 to 2023. Whole-exome sequencing (WES) was linked to electronic health record (EHR) data to associate BAG3 coding variants with EHR phenotypes. This was a health care population-based study including individuals of European and African genetic ancestry in the PMBB with WES linked to EHR phenotypes, with replication studies in BioVU, UK Biobank, MyCode, and DCM Precision Medicine Study.ExposuresCarrier status for BAG3 coding variants.Main Outcomes and MeasuresAssociation of BAG3 coding variation with clinical diagnoses, echocardiographic traits, and longitudinal outcomes.ResultsIn PMBB (n = 43 731; median [IQR] age, 65 [50-76] years; 21 907 female [50.1%]), among 30 324 European and 11 198 African individuals, the common C151R variant was associated with decreased risk for DCM (odds ratio [OR], 0.85; 95% CI, 0.78-0.92) and simultaneous increased risk for HCM (OR, 1.59; 95% CI, 1.25-2.02), which was confirmed in the replication cohorts. C151R carriers exhibited improved longitudinal outcomes compared with noncarriers as assessed by age at death (hazard ratio [HR], 0.85; 95% CI, 0.74-0.96; median [IQR] age, 71.8 [63.1-80.7] in carriers and 70.3 [61.6-79.2] in noncarriers) and heart transplant (HR, 0.81; 95% CI, 0.66-0.99; median [IQR] age, 56.7 [46.1-63.1] in carriers and 55.6 [45.2-62.9] in noncarriers). C151R was associated with reduced risk of DCM (OR, 0.42; 95% CI, 0.24-0.74) and heart failure (OR, 0.27; 95% CI, 0.14-0.50) among individuals harboring truncating TTN variants in exons with high cardiac expression (n = 358).Conclusions and RelevanceBAG3 C151R was identified as a bidirectional modulator of risk along the DCM-HCM spectrum, as well as an important genetic modifier variant in TTN-mediated DCM. This work expands on the understanding of the etiology and penetrance of DCM, suggesting that BAG3 C151R is an important genetic modifier variant contributing to the variable expressivity of DCM, warranting further exploration of its mechanisms and of genetic modifiers in DCM more broadly.
Analyzing Carrier Density and Hall Mobility in Impurity‐Free Silicon Virtually Doped by External Defect Placement
Authors: Nagarajan Soundarya , Ratschinski Ingmar , Schmult Stefan , Wirth Steffen , König Dirk , Mikolajick Thomas , Hiller Daniel , Trommer Jens 
Published: November 2024

AbstractImpurity doping at the nanoscale for silicon is becoming less efficient with conventional techniques. Here, an alternative virtual doping method is presented for silicon that can achieve an equivalent carrier density while addressing the primary limitations of traditional doping methods. The doping for silicon is carried out by placing aluminum‐induced acceptor states externally in a silicon dioxide dielectric shell. This technique can be referred to as direct modulation doping. The resistivity, carrier density, and mobility are investigated by Hall effect measurements to characterize the carrier transport using the new doping method. The results thereof are compared with carrier transport analysis of conventionally doped silicon at room‐temperature, demonstrating a 100% increase in carrier mobility at equal carrier density. The sheet density of hole carriers in silicon due to modulation doping remains nearly constant, ≈4.7 × 1012 cm−2 over a wide temperature range from 300 down to 2 K, proving that modulation‐doped devices do not undergo carrier freeze‐out at cryogenic temperatures. In addition, a mobility enhancement is demonstrated with an increase from 89 cm2 Vs−1 at 300 K to 227 cm2 Vs−1 at 10 K, highlighting the benefits of the new method for creating emerging nanoscale electronic devices or peripheral cryo‐electronics to quantum computing.
The Reduced Barrier for the Photogenerated Charge Migration on Covalent Triazine‐Based Frameworks for Boosting Photocatalytic CO2 Reduction Into Syngas
Authors: Kong Ke , Zhong Hong , Zhang Fushuai , Lv Haowei , Li Xiaoju , Wang Ruihu 
Published: November 2024

AbstractPhotocatalytic CO2 reduction together with hydrogen generation is a promising approach to generate syngas, the photogenerated electron migration from photosensitizers to the catalytic active sites is the rate‐determining step. Herein, an integrative strategy is presented by covalently grafting metal complexes into donor–acceptor covalent triazine‐based frameworks. The catalytic active sites are integrated with the photosensitizer units by covalent linkages to form an extended π‐conjugated framework, which significantly reduces the energy barrier for the migration of the photogenerated charge carriers, resulting in high activity and durability in photocatalytic CO2 reduction into syngas under visible light irradiation. The CO and H2 evolution amounts in 1.5 h are 1086 and 1042 µmol g−1, respectively, which greatly surpass those in the host‐guest counterparts. Furthermore, selective adsorption for CO2 over N2 renders this photocatalytic system to be effective for syngas production from the simulated flue gas. This study provides new approaches to construct the integrative photocatalytic systems for solar‐to‐chemical energy conversion.
Hydrogel Elastic Energy: A Stressor Triggering an Adaptive Stress‐Mediated Cell Response
Authors: Lipari Sara , Sacco Pasquale , Cok Michela , Scognamiglio Francesca , Romano Maurizio , Brun Francesco , Giulianini Piero Giulio , Marsich Eleonora , Aachmann Finn L. , Donati Ivan 
Published: November 2024

AbstractThe crosstalk between the cells and the extracellular matrix (ECM) is bidirectional and consists of a pushing/pulling stretch exerted by the cells and a mechanical resistance counteracted by the surrounding microenvironment. It is widely recognized that the stiffness of the ECM, its viscoelasticity, and its overall deformation are the most important traits influencing the response of the cells. Here these three parameters are combined into a concept of elastic energy, which in biological terms represents the mechanical feedback that cells perceive when the ECM is deformed. It is shown that elastic energy is a stress factor that influences the response of cells in three‐dimensional (3D) cultures. Strikingly, the higher the elastic energy of the matrix and thus the mechanical feedback, the higher the stress state of the cells, which correlates with the formation of G3BP‐mediated stress granules. This condition is associated with an increase in alkaline phosphatase (ALP) activity but a decrease in gene expression and is mediated by the nuclear translocation of Yes‐associated protein (YAP). This work supports the importance of considering the elastic energy as mechano‐controller in regulating cellular stress state in 3D cultures.
Ultraviolet Laser Activation of Phosphorus‐Doped Polysilicon Layers for Crystalline Silicon Solar Cells
Authors: Wang Yijun , Yan Di , Michel Jesus Ibarra , Mahasivam Sanje , Bansal Vipul , Delaney Robert , Wang Jiali , Truong Thien , Zheng Peiting , Yang Jie , Zhang Xinyu , Bullock James 
Published: November 2024

AbstractIn crystalline silicon photovoltaics (c‐Si PV), a pulsed laser can be used as a substitute for a high‐temperature furnace dopant diffusion/activation step. In contrast to furnace‐based activation, lasers can be used to achieve highly localized doping with controlled dopant concentrations, useful in advanced architectures such as the interdigitated back contact (IBC) solar cell. In this study, a pulsed ultraviolet (UV) laser is utilized for phosphorus dopant activation within a low‐pressure chemical vapor deposited (LPCVD) polycrystalline silicon (poly‐Si) passivated contact layer. The highest implied open‐circuit voltage iVoc values achieved using this approach reach 726 mV. However, this comes at the expense of high specific contact resistivities ρc, which is attributed to a lower dopant concentration across the poly‐Si(n+)/SiOx/c‐Si interface. Regardless, the optimum iVoc, ρc combination is measured at a laser fluence of 0.78 J cm−2 producing values of 712 mV and 89 mΩ‐cm2, respectively. These values are still compatible with high‐efficiency solar cell designs, underscoring the feasibility and effectiveness of this approach.
Digital Etching of Molybdenum Interconnects Using Plasma Oxidation
Authors: Erofeev Ivan , Hartanto Antony Winata , Khan Muhaimin Mareum , Deng Kerong , Kumar Krishna , Aabdin Zainul , Tjiu Weng Weei , Zhang Mingsheng , Pacco Antoine , Philipsen Harold , Chowdhuri Angshuman Ray , Huynh Han Vinh , Holsteyns Frank , Mirsaidov Utkur 
Published: November 2024

AbstractMolybdenum (Mo) has a high potential of becoming the material of choice for sub‐10 nm scale metal structures in future integrated circuits (ICs). Manufacturing at this scale requires exceptional precision and consistency, so many metal processing techniques must be reconsidered. In particular, present direct wet chemical etching methods produce anisotropic etching profiles with significant surface roughness, which can be detrimental to device performance. Here, it is shown that polycrystalline Mo nanowires can be etched uniformly using a cyclic two‐step “digital” method: the metal surface is first oxidized with isotropic oxygen plasma to form a layer of MoO3, which is then selectively removed using either wet chemical or dry isotropic plasma etching. These two steps are repeated in cycles until the intended metal recess is achieved. High uniformity of plasma oxidation defines the etching uniformity, and small metal recess per cycle (typically 1–2 nm) provides precise control over the etching depth. This method can replace wet etching where high etching precision is needed, enabling the reliable manufacturing of nanoscale metal interconnects.
Titanium Dioxide: A Versatile Earth‐Abundant Optical Material for Photovoltaics
Authors: Marcelis Eloy J. , ten Elshof Johan E. , Morales‐Masis Monica 
Published: November 2024

AbstractTitanium dioxide (TiO2) has long been receiving attention as a promising material for enhancing the performance of photovoltaic devices due to its tunable optoelectronic properties. This paper reviews the utilization of TiO2 in recent photovoltaic applications, focusing primarily on its role as an optical material. The fundamental properties of TiO2 are reviewed, such as its wide bandgap and unique property of tunable refractive index. Furthermore, various strategies are discussed to harness the fundamental properties of TiO2 to improve light absorption and charge carrier generation within various photovoltaic devices. Overall, the pivotal role of TiO2 as an Earth‐abundant and non‐critical optical material is highlighted for future advances in the power conversion efficiency and viability of photovoltaic technologies, paving the way for future research and developments aimed at achieving sustainable and cost‐effective solar energy conversion.
Highly Tunable, Nanomaterial‐Functionalized Structural Templating of Intracellular Protein Structures Within Biological Species
Authors: Song Dae‐Hyeon , Song Chang Woo , Cho Seunghee H. , Kwon Tae Yoon , Jung Hoeyun , Park Ki Hyun , Kim Jiyun , Seo Junyoung , Yoo Jaeyoung , Kim Minjoon , Lee Gyu Rac , Hwang Jisung , Lee Hyuck Mo , Shin Jonghwa , Shin Jennifer H. , Jung Yeon Sik , Chang Jae‐Byum 
Published: November 2024

AbstractInside living organisms, proteins are self‐assembled into diverse 3D structures optimized for specific functions. This structure‐function relationship can be exploited to synthesize functional materials through biotemplating and depositing functional materials onto protein structures. However, conventional biotemplating faces limitations due to the predominantly intracellular existence of proteins and associated challenges in achieving tunability while preserving functionality. In this study, Conversion to Advanced Materials via labeled Biostructures (CamBio), an integrated biotemplating platform that involves labeling target protein structures with antibodies followed by the growth of functional materials, ensuring outstanding nanostructure tunability is proposed. Protein‐derived plasmonic nanostructures created by CamBio can serve as precise quantitative tools for assessing target species is demonstrated. The assessment is achieved through highly tunable and efficient surface‐enhanced Raman spectroscopy (SERS). CamBio enables the formation of dense nanogap hot spots among metal nanoparticles, templated by diverse fibrous proteins comprising densely repeated monomers. Furthermore, iterative antibody labeling strategies to adjust the antibody density surrounding targets, amplifying the number of nanogaps and consequently improving SERS performance are employed. Finally, cell‐patterned substrates and whole meat sections as SERS substrates, confirming their easily accessible, cost‐effective, scalable preparation capabilities and dimensional tunability are incorporated.
From Images to Genes: Radiogenomics Based on Artificial Intelligence to Achieve Non‐Invasive Precision Medicine in Cancer Patients
Authors: Guo Yusheng , Li Tianxiang , Gong Bingxin , Hu Yan , Wang Sichen , Yang Lian , Zheng Chuansheng 
Published: November 2024

AbstractWith the increasing demand for precision medicine in cancer patients, radiogenomics emerges as a promising frontier. Radiogenomics is originally defined as a methodology for associating gene expression information from high‐throughput technologies with imaging phenotypes. However, with advancements in medical imaging, high‐throughput omics technologies, and artificial intelligence, both the concept and application of radiogenomics have significantly broadened. In this review, the history of radiogenomics is enumerated, related omics technologies, the five basic workflows and their applications across tumors, the role of AI in radiogenomics, the opportunities and challenges from tumor heterogeneity, and the applications of radiogenomics in tumor immune microenvironment. The application of radiogenomics in positron emission tomography and the role of radiogenomics in multi‐omics studies is also discussed. Finally, the challenges faced by clinical transformation, along with future trends in this field is discussed.
Inactivation of Pseudovirus Expressing the D614G Spike Protein Mutation using Nitric Oxide‐Plasma Activated Water
Authors: Patel Paritosh , Kaushik Neha , Acharya Tirtha Raj , Lenka Sudakshya S. , Ghosh Soujanya , Wahab Rizwan , Verma Suresh K. , Choi Eun Ha , Kaushik Nagendra Kumar 
Published: November 2024

AbstractVariants of concern (VOCs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) exhibit high infectivity due to mutations, particularly in the spike protein, that facilitate enhanced binding of virus to human angiotensin‐converting enzyme 2 (hACE2). The D614G mutation, situated in S1‐domain, promotes the open conformation of spike protein, augmenting its interaction with hACE2. Activated water neutralizes pathogens by damaging biological molecules; however, its effect on mutated SARS‐CoV‐2 or VOCs requires further exploration. Here, the efficacy of nitric oxide (NOx)‐plasma activated water (PAW) in inhibiting infections by SARS‐CoV‐2 pseudovirus expressing D614G‐mutated spike protein is investigated, which serves as a model for mutated SARS‐CoV‐2. Results demonstrated high prevalence of D614G mutation in SARS‐CoV‐2 and its VOCs. NOx‐PAW is non‐toxic to cells at high concentration, inhibiting infection by 71%. Moreover, NOx‐PAW induced structural changes in S1‐domain of spike protein, reducing its binding affinity and lowering clathrin‐mediated endocytosis‐related gene expression. Additionally, in silico analysis revealed NOx species in NOx‐PAW played key role in impairing S1‐domain function of the mutated SARS‐CoV‐2 pseudovirus by interacting directly with it. Collectively, these findings reveal the potent inactivation ability of PAW against mutated SARS‐CoV‐2 and suggest its potential application in combating emerging variants of SARS‐CoV‐2 and other viral threats.
Impact of Ion Migration on the Performance and Stability of Perovskite‐Based Tandem Solar Cells
Authors: Shah Sahil , Yang Fengjiu , Köhnen Eike , Ugur Esma , Khenkin Mark , Thiesbrummel Jarla , Li Bor , Holte Lucas , Berwig Sebastian , Scherler Florian , Forozi Paria , Diekmann Jonas , Peña‐Camargo Francisco , Remec Marko , Kalasariya Nikhil , Aydin Erkan , Lang Felix , Snaith Henry , Neher Dieter , De Wolf Stefaan , Ulbrich Carolin , Albrecht Steve , Stolterfoht Martin 
Published: November 2024

AbstractThe stability of perovskite‐based tandem solar cells (TSCs) is the last major scientific/technical challenge to be overcome before commercialization. Understanding the impact of mobile ions on the TSC performance is key to minimizing degradation. Here, a comprehensive study that combines an experimental analysis of ionic losses in Si/perovskite and all‐perovskite TSCs using scan‐rate‐dependent current–voltage (J–V) measurements with drift‐diffusion simulations is presented. The findings demonstrate that mobile ions have a significant influence on the tandem cell performance lowering the ion‐freeze power conversion efficiency from >31% for Si/perovskite and >30% for all‐perovskite tandems to ≈28% in steady‐state. Moreover, the ions cause a substantial hysteresis in Si/perovskite TSCs at high scan speeds (400 s−1), and significantly influence the performance degradation of both devices through internal field screening. Additionally, for all‐perovskite tandems, subcell‐dominated J–V characterization reveals more pronounced ionic losses in the wide‐bandgap subcell during aging, which is attributed to its tendency for halide segregation. This work provides valuable insights into ionic losses in perovskite‐based TSCs which helps to separate ion migration‐related degradation modes from other degradation mechanisms and guides targeted interventions for enhanced subcell efficiency and stability.
Synthesis and Properties of Covalently Linked Fluorescent Tetrads Containing Two BODIPYs and Two 3‐Pyrrolyl BODIPYs
Authors: Chauhan Pinky , Ravikanth Mangalampalli 
Published: November 2024

AbstractTwo covalently linked fluorescent tetrads containing two BODIPY units and two 3‐pyrrolyl BODIPY units have been synthesized over a sequence of steps starting with bis(3‐pyrrolyl BODIPY) as the key precursor. Both covalently linked tetrads 6 and 7 were confirmed by HR‐MS and characterized and studied by 1D and 2D NMR, absorption, cyclic voltammetry, steady state and time‐resolved fluorescence techniques, and also by DFT and TD‐DFT methods. The tetrad 6 exhibited one strong absorption band at 680 nm whereas the tetrad 7 showed strong absorption bands at 510 nm and 648 nm corresponding to BODIPY and 3‐pyrrolyl BODIPY units respectively and the absorption band of tetrad 6 was bathochromically shifted due to effective π‐conjugation in tetrad 6 compared to tetrad 7. The electrochemical studies revealed that tetrads exhibit only two reductions indicating their electron deficient nature. The steady state and time‐resolved fluorescence studies invoked a possibility of singlet‐singlet energy transfer from BODIPY units to 3‐pyrrolyl BODIPY units in one of the tetrads upon selective excitation of BODIPY unit. In this tetrad, the BODIPY unit acts as an energy donor whereas the 3‐pyrrolyl BODIPY unit acts as an energy acceptor. The theoretical studies were corroborated with experimental results. Group webpage: https://ravikanthlab.wixsite.com/mysite/.
Pathologic dural invasion is associated with regional recurrence in olfactory neuroblastoma: A multi‐institutional study
Authors: Tang Anthony , Taori Suchet , Fung Nicholas , Almeida Joao Paulo , Champagne Pierre‐Olivier , Fernandez‐Miranda Juan C. , Gardner Paul , Hwang Peter H. , Nayak Jayakar V. , Patel Chirag , Patel Zara M. , Celda Maria Peris , Pinheiro‐Neto Carlos , Sanusi Olabisi , Snyderman Carl , Thorp Brian D. , Van Gompel Jamie J. , Zenonos Georgios A. , Zwagerman Nathan T. , Wang Eric W. , Geltzeiler Mathew , Choby Garret 
Published: November 2024

AbstractObjectiveNeck metastases are a poor prognostic factor in olfactory neuroblastoma (ONB). Pathologic dural invasion (pathDI) may increase the risk of neck metastases due to invasion of dural lymphatics. We aim to evaluate the prognostic value of pathDI in predicting rates of neck metastases and recurrence using a large, multicenter database of ONB patients.Data sourcesRetrospective review of a prospective, multicenter database of electronic health records of all patients who presented with ONB between 2005 and 2021 at nine tertiary academic care centers within North America.Review methodsClinicopathologic features including modified Kadish staging systems, margin status, treatment modalities, Hyams grading, follow‐up time, and survival.ResultsOf 258 ONB patients, 189 patients met the inclusion criteria. The 10‐year neck recurrence‐free survival (neck‐RFS) rates were 85.7% (75.6‒97.3) and 61.8% (47.9‒79.8) for patients without and with pathDI, respectively (p = 0.018). Time‐to‐event multivariable regression analysis found pathDI to have an odds ratios of 9.7 (95% confidence interval [CI] 1.2–80.4, p = 0.04) for neck‐RFS and 9.5 for RFS at any site (95% CI 1.1–83.3, p = 0.04).ConclusionIn multivariable analysis, the presence of pathDI appears to be the strongest predictor of neck recurrence and recurrence at any site. Future studies exploring the benefit of elective neck dissection or radiation for patients with pathDI may impact disease management.