bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendations for the quantitative basic evaluation of mind-body medicine courses for university students – results of a consensus-based, systematic decision-making process by experts
Authors: Adam Daniela , Vogelsänger Peter , Brinkhaus Benno , Stöckigt Barbara 
Published: November 2024

Abstract
Background
There is an increasing range of mind–body medicine (MBM) courses in Germany to support university students in dealing with stress. The evaluation of these varies and often only has a small number of participants due to the limited group size of the courses. The aim of this project was the development of a quantitative basic evaluation that can be used across all sites that conduct MBM courses.

Methods
In a consensus-based and systematic decision-making process, the learning objectives and various questionnaires for the evaluation of MBM courses were discussed and evaluated by experts according to defined criteria. The process was iterative, in which the reflection and definition of the learning objectives and the questionnaires were conditional and adapted if necessary. The recommendations for the basic evaluation of students’ MBM courses were developed by consensus among the experts.

Results
For the experts, the most important learning objectives of the MBM courses were stress reduction and self-experience with the exercises. A total of 21 questionnaires were evaluated from nine topics: mindfulness, empathy, self-reflection, self-efficacy, resilience, stress, sense of coherence, quality of life, and well-being. Finally, eight questionnaires were recommended by the expert group for use in a basic evaluation: stress (PSS-10), quality of life (WHOQOL-Bref), mindfulness (MAAS), self-efficacy (GSE), self-compassion (SCS), empathy (SPF), self-reflection (GRAS) and sense of coherence (SOC-13). Further questionnaires were recommended as "optional". An additional qualitative evaluation is recommended for a broader and deeper understanding of the quantitative results.

Conclusions
The proposed basic evaluation is the central result of the iterative consensus-based decision-making process, which reflects the learning objectives of the underlying MBM courses. We hope that the basic evaluation will be integrated into other MBM courses so that results of various courses can be pooled and compared across sites in the future. This could increase the informative value of the evaluations. Furthermore, researchers could consider the use of the basic evaluation in clinically controlled trials on MBM.

Trial registration
The project was not registered in a clinical trial registry because no results from health care interventions on human participants have been analyzed or reported.
Creating a sense of place when implementing a new emergency department in Denmark: a qualitative study
Authors: Kirk Jeanette Wassar , Nilsen Per , Andersen Ove , Stefánsdóttir Nina Thórný , Lindstrøm Mette Bendtz , Powell Byron J. , Tjørnhøj-Thomsen Tine 
Published: November 2024

Abstract
Background
Physical locations play an essential yet often overlooked role in healthcare implementation processes. Implementation Science frameworks such as the Theoretical Domains Framework, the Consolidated Framework for Implementation Research, and the Implementation in Context framework acknowledge the importance of the physical environment, but they often treat it as a passive backdrop for change. However, from a cultural geographic perspective, spaces and places are dynamic, influencing behavior, social structures, and the acceptance of new practices. This study aims to explore how managers and emloyees develop a sense of place in a new emergency department (ED) and how these spatial dynamics influence the implementation process.

Methods
This study used a multi-sited ethnographic design, tracking the implementation process across multiple hospital locations from 2019 to 2023. Fieldwork was conducted in settings such as management meetings, micro-simulation training, and tours of the new ED construction site. A total of 53 participants, including managers, nurses, and physicians from 12 specialized departments, were purposively selected. Data were collected through ethnographic field notes (750 single-spaced pages) and semi-structured interviews averaging 39 min. Analysis was guided by situational analysis and cultural geography, integrating human and nonhuman elements. An overall inductive approach was used to develop theory from observations through analysis, applying a coding system to identify key themes related to spaces, places, traces, and sense of place.

Results
Five themes emerged regarding the development of a sense of place: (1) comfort, influenced by physical elements such as daylight and indoor climate; (2) spatial organization, affecting collaboration, workflow, and professional identity; (3) familiarity, highlighting cultural practices and equipment in fostering belonging; (4) time, where construction delays enabled deeper emotional engagement; and (5) involvement, showing that initial criticism transformed into stronger ownership through increased engagement.

Conclusion
This study highlights the importance of a sense of place during pre-implementation of new physical locations in healthcare. Factors such as comfort, spatial organization, familiarity, time, and involvement are key to participants’ development of a strong sense of place in the new ED. These insights are crucial for designing implementation processes that address both physical and emotional needs, influencing outcomes such as acceptability, adoption, and sustainability.
Chronic disease diagnoses and health service use among people who died of illicit drug toxicity in British Columbia, Canada
Authors: Palis Heather , Hu Kevin , Tu Andrew , Scheuermeyer Frank , Staples John A. , Moe Jessica , Haywood Beth , Desai Roshni , Xavier Chloé G. , Xavier Jessica C. , Crabtree Alexis , Slaunwhite Amanda 
Published: November 2024

Abstract
Background
Illicit drug toxicity (i.e., overdose) is the leading cause of death in British Columbia (BC) for people aged 10–59. Stimulants are increasingly detected among drug toxicity deaths. As stimulant use and detection in deaths rises, it is important to understand how people who die of stimulant toxicity differ from people who die of opioid toxicity.

Methods
BC Coroners Service records were retrieved for all people who died of unintentional illicit drug toxicity (accidental or undetermined) between January 1, 2015, and December 31, 2019, whose coroner investigation had concluded and who had an opioid and/or stimulant detected in post-mortem toxicology and identified by the coroner as relevant to the death (N = 3788). BC Chronic Disease Registry definitions were used to identify people with chronic disease. Multinomial regression models were used to examine the relationship between chronic disease diagnoses and drug toxicity death type.

Results
Of the 3788 deaths, 11.1% (N = 422) had stimulants but not opioids deemed relevant to the cause of death (stimulant group), 26.8% (N = 1014) had opioids but not stimulants deemed relevant (opioid group), and 62.1% (N = 2352) had both opioids and stimulants deemed relevant (opioid/stimulant group). People with ischemic heart disease (1.80 (1.14–2.85)) and people with heart failure (2.29 (1.25–4.20)) had approximately twice the odds of being in the stimulant group as compared to the opioid group.

Conclusions
Findings suggest that people with heart disease who use illicit stimulants face an elevated risk of drug toxicity death. Future research should explore this association and should identify opportunities for targeted interventions to reduce drug toxicity deaths among people with medical comorbidities.
Is the diagnosis and treatment of depression gender-biased? Evidence from a population-based aging cohort in Sweden
Authors: Bacigalupe Amaia , Martín Unai , Triolo Federico , Sjöberg Linnea , Sterner Therese Rydberg , Dekhtyar Serhiy , Fratiglioni Laura , Calderón-Larrañaga Amaia 
Published: November 2024

Abstract
Background
As compared to men, older women´s higher rates of depression diagnosis and antidepressant use are widely reported. We aimed to: a) explore whether there is a potential gender bias in the clinical diagnosis of depression and antidepressant prescription in an older population from Stockholm; and 2) analyze if such gender bias differs by patients’ age and socioeconomic status.

Methods
We used data from the Swedish National Study on Aging and Care in Kungsholmen, SNAC-K (N = 2,941). We compared gender differences in: (a) clinical diagnosis of depression according to the Swedish National Patient Register (ICD-10 codes F32-F34; F412) (“register-based diagnosis”); (b) SNAC-K-based diagnosis of depression, partially gender-blind, using the Comprehensive Psychopathological Rating Scale (CPRS) and the DSM-IV-TR (“SNAC-K based diagnosis); and (c) antidepressant use (ATC code N06A). To analyze the magnitude of the gender bias in the register-based diagnosis of depression and in antidepressant use, and the role of potential moderating factors, prevalence ratios (PR) were calculated using Poisson regression models. Models were run separately by age and social class.

Results
Women had a 63% higher probability of having a register-based diagnosis of depression (PR = 1.63[1.23–2.15]) and a 79% higher probability of using antidepressants (PR = 1.79[1.34–2.40]). No gender differences were observed in the SNAC-K-based diagnosis of depression. The gender differences in the register-based diagnosis were narrowed, although remained significant, after considering age, depressive symptoms, and health services use (PR = 1.44[1.10–1.88]), as well as the register-based diagnosis in the case of antidepressant use (PR = 1.31[1.04–1.64]). This gender bias was larger among the younger-old and the most advantaged social class.

Conclusion
A gender-bias was identified in the diagnosis and treatment of depression in older adults within the Swedish healthcare setting, which could imply that health services may be contributing to the medicalization of women’s mental health. Gender-sensitive clinical and public health interventions are essential to reduce gender disparities in mental healthcare, also in old age.
Predictors of care home resident conveyance to hospital or referral to community pathways by a regional ambulance service attending medical emergencies: a retrospective cross sectional study
Authors: Siriwardena Aloysius Niroshan , Botan Vanessa , Law Graham , Laparidou Despina , Phung Viet-Hai , Curtis Ffion , Whitley Gregory Adam , Akanuwe Joseph , Rowan Elise , Fothergill Rachael , Bowler Susan , Kordowicz Maria , Palastanga Nicoya , Wilkins Lissie , Spaight Robert , Miller Elizabeth , Gordon Adam 
Published: November 2024

Abstract
Background
Care home residents are at higher risk compared with community dwelling elders for medical emergencies, often resulting in ambulance attendance and conveyance to hospital. We aimed to determine the factors predicting care home resident conveyance to hospital or referral to community pathways by an ambulance service.

Methods
We used a retrospective cross-sectional study design analysing routine data from electronic clinical records from East Midlands Ambulance Service NHS Trust (EMAS). Data comprised all patients including care home residents attended by ambulance from 2018 to 2021. A multivariable logistic regression model was used to identify the main predictors of conveyance to hospital or referral to community services.

Results
Data included 170,612 attendances to care homes representing 7.5% of the total number of EMAS attendances between 2018 and 2021. The main predictors of conveyance to hospital were being male (Relative Risk Ratio [RRR] 1.07, 95% Confidence Interval [CI] 1.03–1.10, p < 0.001), aged 70–79 years (RRR 1.09, 95%CI 1.03–1.17, p < 0.001) or 80–89 years (RRR 1.10, 95%CI 1.03–1.17, p < 0.001), situated in an area of higher deprivation (RRR 1.06, 95%CI 1.03–1.09, p < 0.001), or having dispatch categories which included cardiovascular (RRR 11.29, 95%CI 10.43–12.22, p < 0,001), trauma such as falls (RRR 9.50, 95%CI 8.97–10.05, p < 0,001) or neurological conditions (RRR 9.06, 95%CI 8.42–9.75, p < 0,001). Calls made by health care professionals (HCPs) (RRR 15.37, 95%CI 13.41–17.62, p < 0,001) or where patients had a higher National Early Warning Score (NEWS2) (RRR 1.23, 95%CI 1.22–1.24, p < 0,001) resulted in significantly increased conveyance.

Conclusions
Various factors significantly predicted conveyance of care home residents to hospital by ambulance. These included HCP referral and a higher NEWS2 score confirming that severity of clinical condition of the patient significantly increased conveyance. Future interventions to prevent or address certain conditions such as falls or provide enhanced care in care homes may prevent some emergencies or reduce the likelihood of conveyance to hospital.
BeetRepeats: reference sequences for genome and polymorphism annotation in sugar beet and wild relatives
Authors: Schmidt Nicola , Maiwald Sophie , Mann Ludwig , Weber Beatrice , Seibt Kathrin M. , Breitenbach Sarah , Liedtke Susan , Menzel Gerhard , Weisshaar Bernd , Holtgräwe Daniela , Heitkam Tony 
Published: November 2024

Abstract
Objectives
Despite the advances in genomics, repetitive DNAs (repeats) are still difficult to sequence, assemble, and identify. This is due to their high abundance and diversity, with many repeat families being unique to the organisms in which they were described. In sugar beet, repeats make up a significant portion of the genome (at least 53%), with many repeats being restricted to the beet genera, Beta and Patellifolia. Over the course of over 30 years and many repeat-based studies, over a thousand reference repeat sequences for beet genomes have been identified and many experimentally characterized (e.g. physically located on the chromosomes). Here, we present the collection of these reference repeat sequences for beets.

Data description
The BeetRepeats_v1.0 resource is a comprehensive compilation of all characterized repeat families, including satellite DNAs, ribosomal DNAs, transposable elements and endogenous viruses. The genomes covered are those of sugar beet and closely related wild beets (genera Beta and Patellifolia) as well as Chenopodium quinoa and Spinacia oleracea (all belonging to the Amaranthaceae). The reference sequences are in fasta format and comprise well-characterized repeats from both repeat categories (dispersed/mobile as well as tandemly arranged). The database is suitable for the RepeatMasker and RepeatExplorer2 pipelines and can be used directly for any repeat annotation and repeat polymorphism detection purposes.
Genome-wide identification of root colonization fitness genes in plant growth promoting Pseudomonas asiatica employing transposon-insertion sequencing
Authors: Pranav Parameswaran Sree , Sivakumar Ramamoorthy , Suvekbala Vemparthan , Rajendhran Jeyaprakash 
Published: November 2024

Abstract
Background
Pseudomonas spp. are well-studied plant growth promoters, particularly in the context of root colonization. However, the specific genetic factors that determine its fitness in the rhizosphere remain largely unexplored. This study breaks new ground by employing transposon insertion sequencing (Tn-Seq) to identify the genetic factors in Pseudomonas asiatica JR11 that are crucial for colonizing corn roots.

Results
We created a transposon mutant library of P. asiatica JR11 with 91,884 insertion sites and subjected it to three consecutive enrichment cycles within the corn root system. A total of 79 genes were identified as essential for root colonization (negatively-selected), while 22 genes were found to counteract root colonization efficiency (positively-selected), with both sets being commonly present across all three cycles. These genes involve amino acid metabolism, cell wall biosynthesis, and protein functions. Additionally, we found four negatively-selected and four positively-selected hypothetical proteins that consistently influenced root colonization fitness.

Conclusions
The identification of these molecular determinants opens up exciting possibilities for further research. Understanding these pathways could lead to the development of novel strategies for enhancing the fitness of P. asiatica JR11 during corn root colonization, with potential implications for plant growth promotion and agricultural practices.
The closure of microcracks under pressure: inference from elastic wave velocity and electrical conductivity in granitic rocks
Authors: Watanabe Tohru , Tomioka Arina , Yoshida Kenta 
Published: November 2024

AbstractMeasurements of elastic wave velocity and electrical conductivity were conducted on brine-saturated granitic rocks under confining pressure to quantitatively characterize the closure of cracks. The number of contacting asperities and radius ratio of contact over crack were estimated. Contacting asperities were assumed to deform elastically and/or plastically. The number of contacts increases steeply at low pressure (< 10 MPa) and decreases gradually at higher pressure, while the radius ratio of contact over crack linearly increases. Though the area fraction of contacts increases to no more than 30% even at the highest confining pressure (150 MPa), the stiffness of the solid phase is recovered, and the connectivity of fluid is maintained in a crack. Cracks under pressure are closed for elastic properties, but open for transport properties. The effective aperture is of the order of 100 nm at atmospheric pressure, and steeply decreases at low pressure (< 10 MPa) and then gradually at higher pressure. Observed seismic velocity and electrical conductivity in the crust should be interpreted by considering contacts in cracks. Microstructures of closing cracks should be further investigated to seek relationships between structural parameters and effective pressure.
Graphical abstract
Effect of feed rate during induction hardening on the hardening depth, microstructure, and wear properties of tool-grade steel work roll
Authors: Šapek A. , Kalin M. , Godec M. , Donik Č. , Markoli B. 
Published: November 2024

AbstractRolls are the most critical yet vulnerable parts of cold rolling mills. It is crucial for them to withstand long rolling campaigns without losing surface roughness or incurring damage. Newly developed rolls are made from tool-grade steel with high roughness, lower wear, and high damage resistance. One of the most important advantages is the elimination of the need for chrome plating, which is currently widely used on standard steel rolls but is ecologically harmful. We investigated a type of steel with 8% chromium for use in cold rolling using light optical microscopy (LOM), X-ray crystallography (XRD), scanning electron microscopy (SEM), electron backscatter diffraction (EBSD), hardness measurements, and tribological tests. In this study, a roll with a diameter of 325 mm was electro-slag remelted and forged, machined to a diameter of 305 mm, and quenched and tempered to simulate industrial roll production. A forged roll was induction heated and hardened at four different feed rates (i.e., 24 mm/min, 30 mm/min, 36 mm/min, and 42 mm/min), tempered at 515℃ for 24h and again at 480℃ for 24h, and dissected for in-depth analysis. We identified a clear relationship between the feed rate of the roll during induction hardening and the depth of hardness, the sizes of carbides, and the wear properties of the roll. By reducing the feed rate of the roll through the inductor, we increased the depth of the hardened layer from 16 mm (at a feed rate of 36 mm/min) to 25 mm (at a feed rate of 24 mm/min), which is a 56.25% increase. Such an increase is expected to extend the lifespan of the working roll without having negative effects on the wear resistance and other important parameters. XRD analysis showed that the sample had a 0.4% residual austenite, which means it had a significantly lower risk of roll damage during operation than standard steel grades
Educational design insights for interprofessional immersive simulation to prepare allied health students for clinical placements
Authors: Brentnall Jennie , Rossiter Laura , Judd Belinda , Cowley Emma , McCormick Keith , Turk Ruth , Thackray Debbie 
Published: November 2024

Abstract
Background
Positive outcomes of simulation programmes to prepare students for placement are widely noted. However, few studies adequately describe considerations for designing allied health placement simulations. There exists a conceptual framework to guide such simulation design, which draws on theory and educational expertise but to date lacks varied stakeholder perspectives. This study aimed to identify implications for the design of allied health placement simulation from participants’ experiences of a simulation-based, interprofessional, novice placement preparation programme.

Methods
Occupational therapy, physiotherapy and podiatry students finishing their first year of study were offered a 1-week intensive interprofessional simulation immediately before their first placement. Focus groups in the following weeks allowed participants to discuss their experiences of the programme, preparation for student placements, and recommendations. These were transcribed and interpreted using reflexive thematic analysis and then abductively related to the conceptual framework.

Results
In total, 22 participants broadly representative of the simulation programme participants contributed to separate focus groups with domestic-enrolled students (n = 7), international students (n = 5), external practice educators (n = 6), and simulated participants (n = 4). Inductive reflexive thematic analysis generated six themes: (i) engaging learning environment, (ii) realism and relevance, (iii) student confidence and communication, (iv) international students’ needs, (v) recommendations to facilitate further preparation for placement, and (vi) importance of preparation to engage in simulation.
All participant groups were invested in the programme and highlighted learning opportunities. An immersive and relatable experience with active participation contributed to confidence and communication skill development. International students noted needs pertaining to cultural and language expectations. Other participant recommendations related to the equity of opportunities and specific preparation for placement student-educator interactions. Finally, every participant group noted features of effective preparation for simulation-based education.

Conclusions
Relating these findings abductively to the literature and conceptual frameworks, this study highlights simulation design considerations for learner needs assessment, engagement, realism, psychological safety, and challenge to prepare learners for their first clinical placement. Specific implications for adequately preparing all participant groups, design considerations for the needs of culturally diverse students, and balancing interprofessional and discipline-specific learning are highlighted from a lived experience viewpoint. Future research may engage greater stakeholder co-design in simulation-based education.