bluuebunny/crossref_metadata_2025_split huggingface dataset:
FEATURES OF USING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN DENTAL PRACTICE
Authors: Iordanishvili A. K. , Dyagilev A. I. , Risovannaya O. N. , Skorikov V. Yu. , Popkov V. L. 
Published: October 2018

Aim. This study was conducted to assess the awareness of dentists about the questions of pharmacokinetics and pharmacodynamics of nonsteroidal anti-inflammatory drugs as well as to study the features of their use for the relief of pain syndrome in dental practice.Materials and methods. By means of the questionnaires were studied 107 dentists working in dental clinics and dental departments of General hospitals, especially their use of the nonsteroidal anti-inflammatory drugs for pain relief.Results. It was determined that 85% of doctors use non-selective and moderately selective cyclooxygenase inhibitors (COX), 15%-prefer Cox-2 inhibitor with the pronounced selectivity for pain relief. The highest number of correct answers was given by a group of doctors with work experience from 5 to 10 years (40.3%), the lowest – by doctors with work experience more than 20 years, respectively 40.3% and 36.1% of the total number of doctors from the studied groups.Conclusion. There was noted that it is necessary to pay attention to the peculiarities of pain relief for the improvement of dentists’ work as well as to involve clinical pharmacologists for these purposes.
MICROSTRUCTURE OF STOMATOLOGICAL MATERIAL "RESTAVRIN" BEFORE AND AFTER BACTERIAL COLONIZATION IN THE EXPERIMENT
Authors: Kolodkina V. I. , Arutyunov A. A. , Ovsyannikova A. A. , Babichev S. A. 
Published: October 2018

Aim. This research was conducted to study the electron microscopic microstructure of the surface of the filling material «Restavrin» coated with the «Easy Glaze» sealant and without it before and after bacterial adhesion by scanning electron microscopy.Materials and methods. There was studied the microrelief of the plates preliminarily made from a polymeric nano-hybrid filling material («Restavrin», Technodent, Russia) with and without the sealant «Easy Glaze» and without it both in the initial state and after being placed in a medium with microorganisms. The material for microbiological examination (the contents of the gingival sulcus) was taken from 23 patients with a diagnosis of «dentine caries» by sterile turundas. The test material was directly placed near the patient's chair in a Petri dish with enriched blood agar. Nutrient media with inoculations were delivered to the laboratory for further research. After selecting the necessary area for scanning at the same magnification (×200) (the size of the scanned section is 50x68 μm2) at a certain vertical interval, 6-8 horizontal lines for scanning were selected.Results. Scanning electron microscopy at the end of the 45-day experiment showed that used S.oralis and S.mutans strains (strains isolated from dental patients’ contents of the gingival joint) have a pronounced ability to adhere what indirectly confirms the formation of glucans by them and, accordingly, their cariogenicity. The destructive effect of oral streptococci (S.mutans + S.oralis) on the surface of the filling materials «Restavrin» and «Restavrin» + sealant «Easy Glaze» was experimentally confirmed that clearly manifests itself after 45 days of joining streptococci and filling materials. It should be noted that the restorative material «Restavrin» under the sealant «Easy Glaze» remained nearly intact during the 45-day in vitro experiment.Conclusion. We consider it advisable to recommend the compulsory covering of the restoration with a sealant because it serves as a kind of barrier protecting the filling material from the effect of oral streptococci. Accordingly, this procedure extends the life of the filling and also ensures the preservation of the aesthetic and mechanical properties of the composite restorations.
THE USE OF PREDICTIVE CYTOLOGICAL FEATURES FOR THE SELECTION OF THE METHODOLOGY OF REGENERATIVE TREATMENT OF PATIENTS WITH PERIODONTITIS
Authors: Perova M. D. , Gaivoronskaya T. V. , Karpyuk V. B. , Sevostyanov I. A. , Shipieva U. A. 
Published: October 2018

Aim. This study was conducted to assess the outcome of the results obtained in the treatment of patients with longterm current periodontitis with individual characteristics of the cytological picture of the microenvironment of damaged periodontal tissues.Materials and methods. The main study group included 40 patients with chronical periodontitis of the moderate degree (Mo 56, 7 years). The selection of the regenerative treatment in the main group was carried out in accordance with the preliminary express assessment of the cytological picture of the damaged periodontal tissues. The control group, whose indicators were compared with the main clinical indicators, included 43 patients with randomly selected regenerative treatment.Results. The cell-potential surgical approach statistically induces the growth of new dentogingival junction in patients with critically small amount of morphologically altered neutrophil granulocytes and small cell forms with intense basophilic coloring (≤20%) in cytological samples in comparison with the control decreasing the amount of residual loss of teeth supporting tissues by 2 times.Conclusion. The preliminary express assessment of the cytological picture of the microenvironment of periodontal pockets indirectly indicates the potential of the patient with periodontitis to restore the missing structures of the periodontal membrane. The choice of the surgical tactics of regenerative treatment, taking into account the characteristics of cellular behavior in cytological samples of patients with periodontitis, is advisable to use as a prognostic test to improve the final results.
RESULTS OF CELL-POTENTIATED SURGICAL TREATMENT OF CHRONIC PERIODONTITIS (10 years of observations)
Authors: Perova M. D. , Karpyuk V. B. , Gaivoronskaya T. V. , Sevostyanov I. A. , Fomichiva E. A. , Shipieva U. A. 
Published: October 2018

Aim. The aim of this study is to systematize the scientific knowledge and reconstructed periodontium reliability degree by means of cell-potentiated surgical treatment of patients with the chronic periodontitis.Materials and methods. All 76 patients included in the study (aged 23 to 68 years, Mo 55.3 years) underwent a surgery for directed regeneration of periodontal tissues which was supplemented by transplantation of vascular stromal cell fraction isolated from the patient's adipose tissue (VSF AT). The evaluation of the results of the main periodontal parameters, processed by means of variation statistics in 690 periodontal defects of different topography, was carried out within 10 years.Results. The use of the VSF AT demonstrated the advantage of the method expressed by the formation of a new timeresistant dentogingival junction with the reconstruction of the alveolar bone with a minimum amount of the marginal recession and the probing depth.Conclusion. The percentage of positive results in the representative statistical sample was 90.3% in the main group, 75.6% in the control group within 10 years.
ASPECTS OF DIAGNOSTIC ACTIVITIES IN PATIENTS WITH DYSFUNCTION OF TEMPOROMANDIBULAR JOINTS AND SIGNS OF BRUXISM
Authors: Rubnikovich S. P. , Borodin D. M. , Denisova Yu. L. , Baradina I. N. 
Published: October 2018

Aim. The research was conducted to develop and implement the complex of diagnostic activities in patients with dysfunction of temporomandibular joints with signs of bruxism.Materials and methods. To achieve this aim we conducted a comprehensive diagnosis of 61 patients aged 20-29 years with bruxism and temporomandibular joints dysfunction (TMJD), the patients were divided into two groups. To diagnose and analyze the results of the disease treatment in patients we used a computer analysis with visualization of changes of the osteoarticular surface and parameters of the joint gap in the TMJ. Depending on the ratio of prognostic risk criteria and the development of bruxism, we distinguished the area of low, medium and high level of risk of disease progression.Results. Comparison of the treatment results of patients with bruxism from two groups in 12-24 months showed that patients from the second group had good treatment results. Patients of the second group underwent a complex of diagnostic activities and its data increased the treatment effectiveness. The results obtained from the treatment of patients from the first group indicate the lack of data from the standard examination of patients with bruxism.Conclusion. The developed complex diagnostic activities in patients with bruxism in combination with dysfunction of the TMJ and occlusive attrition of teeth allow to assess not only the local status but also to determine the functional state of dentoalveolar system and the cerebral cortex which affects the amount of therapeutic activities in the patient.
USING MESENCHYMAL STEM CELLS FOR TREATING GINGIVAL RECESSION IN THE EXPERIMENT
Authors: Rubnikovich S. P. , Denisova Yu. L. , Andreeva V. A. , Panasenkova G. Yu. , Khomich I. S. 
Published: October 2018

Aim. This research was conducted to study the type of clinical changes in the diseased periodontal tissues by means of using mesenchymal stem cells for treating gingival recession in the experiment.Materials and methods. Adipose tissue in a volume of 1-2 ml was sampled from one specimen in sterile conditions in order to obtain allogeneic mesenchymal stem cells before the beginning of the experimental studies. Random-bred female white rats (60 specimens) were used as a model in the experiment. The surgical intervention was performed in the area of incisors on the upper and lower jaws of rats. All animals were divided into 5 groups (10 rats in each group) depending on the planned method of the treatment. The control group, intact rats, consisted of 10 laboratory animals with a healthy gingiva. The creation of a model of the experimental gingival recession was carried out by the mechanical V-shaped excision of periodontal tissues.Results. The experimental studies showed the possibility of complete regeneration of the dentogingival papillae as well as periodontal tissues regeneration in the area of the experimental gingival recession during the first 28 days. Meanwhile, there is a complete absence of inflammatory signs in the 5th group (hyperemia, edema, gingival bleeding), along with their significant decrease in the 3rd and the 4th groups that confirms the pronounced therapeutic effect of mesenchymal stem cells and sterile bioplastic collagen material «Collost» (7% gel).The conclusion. While studying the type of clinical changes in diseased periodontal tissues using mesenchymal stem cells in the treatment of gingival recession, we established the positive dynamics in the experiment. The decrease in the intensity and prevalence of gingival inflammation starts from the 14th day. On the 28th day there was noted a complete absence of inflammatory signs in the animals after injecting the transplant consisting of the cell suspension on the sterile bioplastic material Collost (7% gel). Furthermore, the significant increase in the regeneration of the gingival margin was observed on the 24th day from the moment of creating the gingival recession model. The complete regeneration of the dentogingival papillae and the absence of the gingival recession were noted on the 38th day of general observation.
COMPARATIVE CHARACTERISTICS OF THE MEANS PREVENTING THE APPEARANCE OF THE INHIBITED LAYER ON THE SURFACE OF THE COMPOSITE
Authors: Tairov V. V. , Arutunova A. A. , Egunyan K. K. , Kamyshnikova I. O. , Ivashchenko V. A. , Risovannyj S. I. 
Published: October 2018

Aim. This study was designed to evaluate the effectiveness of preventing the formation of a layer inhibited by oxygen or reducing its amount using various means.Materials and methods. The study was performed at the Department of Therapeutic Dentistry of the FSBEI HE KubSMU of the Ministry of Health care of Russia and the laboratory instrument factory "Cascade", Krasnodar. The composite Filtek Ultimate (3M ESPE, USA) was used for the production of model samples by placing the composite material in clean plastic molds with a diameter of 13.5 mm, thickness of 4 mm and polymerization, the following materials were selected to prevent contact of oxygen with the surface of the composite: glycerin solution, lavsan plate, Teflon tape. For the comparison with the standard method of elimination of the layer inhibited by oxygen we used the finishing of the surface of the composite. The surface hardness of the samples of each group and subgroup was measured using the apparatus-hardness tester PMT-3 by the Vickers method. The multivariate analysis of variance (ANOVA) was conducted in Statistica software 13. The samples were stained separately with a solution of "Lipton" tea from 2015 for 3 years. The degree of pigment deposition was evaluated.Results. The determining factor in the long-term functioning of the composite restoration is the stability of the surface layer. The results of the study showed the lowest microhardness of the samples from the group without any blockers of oxygen penetration without finishing (56HV), the highest microhardness was in samples from the group covered with Teflon tape with finishing (107HV). The probability value p<0.05 was obtained for all study groups. The results of the color change of the restoration were evaluated in the coloring medium. The assessment of changes in the coloring was carried out for 3 years. The results of staining allowed to confirm the obtained data of the study: 1) the intensity of staining of all samples increases over time, 2) the samples from the groups without glycerin coating were stained to a greater extent before the polymerization, without finishing in comparison with the samples from the groups without glycerin but with finishing, 3) the sample with glycerin coating and finishing was stained the least.Conclusion. Thus, the results of the study allow us to recommend using the means preventing the formation of the oxygeninhibited later to improve the efficiency of the restoration of the composite and increase the duration of its functioning. Depending on the clinical situation, glycerin, lavsan plate or Teflon tape can be used as oxygen blockers.
Two-dimensional system of strongly interacting electrons in silicon (100) structures
Authors: Dolgopolov V T 
Published: October 2018

Abstract
Studies of various experimental groups that explore the properties of a two-dimensional electron gas in silicon semiconductor systems ((100) Si-MOSFET and (100) SiGe/Si/SiGe quantum wells) in the vicinity of the metal–insulator transition are described and critically analyzed. Results are identified that are common to all research: (i) the effective mass of electrons measured at the Fermi level in the metallic region increases as the electron density decreases and, if extrapolated, tends to diverge; (ii) the behavior of the energy-averaged mass in the metallic region is quite different in the two systems: in Si-MOSFETs, it also exhibits a tendency to diverge, while in the SiGe/Si/SiGe quantum wells it saturates in the limit of low electron densities; (iii) there is a small number (depending on the sample quality) of localized electrons in the metallic phase; (iv) the properties that the electron system exhibits in the insulating phase in the vicinity of the metal–insulator transition are typical of amorphous media with a strong coupling between particles.
Morphological expression of the extrahepatic bile duct. A study in a sample of Colombian mestizo population
Authors: Saldarriaga Tellez Bladimir , Corzo Gomez Edgar Giovanni , Forero Porras Pedro Luis , Ballesteros Acuña Luis Ernesto 
Published: October 2018

Background: The great variability of the extrahepatic bile duct (EBD) has clinical-surgical implications. The objective of this study was to characterize the morphological expressions of EBD.
Methods and findings
This descriptive study, done by injecting a semi-synthetic (Palatal GP40L 85%; styrene 15%) impregnated with mineral green dye into the gallbladder, to determine the anatomical characteristics and the biometrics of EBD in 33 blocks formed from the supra-mesocolic floor.The gallbladder presented a length of 66.9 ± 1.7 mm. The Hartmann´s Pouch was observed in 16 specimens (50%). The lengths of the cystic duct (CD), common hepatic duct (CHD) and common bile duct (choledoch duct) were 27.8 ± 1.6 mm, 28.6 ± 11.39 mm and 60.6 ± 11.6 mm respectively.
The presence of accessory hepatic ducts (AHD) was found in three samples (9.1%). In 29 specimens (87.9%) the cystic duct presented medium length, while in 4 cases (12.1%) the CD was long (P < 0, 05). The trajectory of the lateral oblique of CD was present in 23 cases (69.7%), with statistically significant differences in relation to the other trajectories of the CD (P <0, 05). In 18 samples (55%) the cystic-hepatic union appeared at the level of the middle third of the EBD, while in 15 (45%) cases the union of the CD was low (P<0,05).
Conclusions
The mathematical distribution of the segments of the EBD, carried out in this study, provides reliability to the assessment of the cystic-hepatic junction level. The presence of CHA and the level of the cysto-hepatic junction are important anatomical references, especially in emergency room procedures.
Some Spawning Performance Parameters of Cultured Nile Tilapia Oreochromis niloticus, under Brackish Water
Authors: Mashaii Nassrin , Rajabipour Farhad , Jafari Mohamad , Mohammadi Mohammad , Sarsangi Habib , Hosein-Zadeh Homayun , Matinfar Abbas 
Published: October 2018

Tilapia is one of the most important cultured fish in the world. However, the gap between seed supplies and farmers' demand is one of the serious limitations for tilapia culturists. Notice about different effective agents on tilapia reproduction might be useful for increasing of production and better management of tilapia hatcheries. In the present study, higher efficiency of tilapia Oreochromis niloticus hatchery was considered based on the impact of sex ratio, stocking density, photoperiod, water salinity and replacement period on spawning performance. Sex ratios 1:1, 1:4 and 1:7 (Male: Female), stocking densities 2, 3.5 and 5 fish/m3, photoperiods 6:18, 12:12 and 18:6 (Light:Dark), water salinities 12, 8, 4 and 0 ppt, also10 and 15 days replacement of breeders were studied. Fecundity,breeder and egg per day,spawning intervals, egg diameter and weight were investigated. Results showed stocking density 5 fish/m3, photoperiod 12:12, 8 ppt water salinity and 10 days replacement had better performance. Sex ratio treatments had similar performance.
Cost‐effectiveness of immune checkpoint inhibitors for microsatellite instability–high/mismatch repair–deficient metastatic colorectal cancer
Authors: Chu Jacqueline N. , Choi Jin , Ostvar Sassan , Torchia James A. , Reynolds Kerry Lynn , Tramontano Angela , Gainor Justin F. , Chung Daniel C. , Clark Jeffrey W. , Hur Chin 
Published: October 2018

BackgroundPatients with microsatellite instability–high (MSI‐H)/mismatch repair–deficient (dMMR) metastatic colorectal cancer (mCRC) show a significant response to checkpoint inhibitor therapies, but the economic impact of these therapies is unknown. A decision analytic model was used to explore the effectiveness and cost burden of MSI‐H/dMMR mCRC treatment.MethodsThe treatment of hypothetical patients with MSI‐H/dMMR mCRC was simulated in 2 treatment scenarios: a third‐line treatment and an exploratory first‐line treatment. The treatments compared were nivolumab, ipilimumab and nivolumab, trifluridine and tipiracil (third‐line treatment), and mFOLFOX6 and cetuximab (first‐line treatment). Disease progression, drug toxicity, and survival rates were based on the CheckMate 142, study of TAS‐102 in patients with metastatic colorectal cancer refractory to standard chemotherapies (RECOURSE), and Cancer and Leukemia Group B/Southwest Oncology Group 80405 trials. The analyzed outcomes included survival (life‐years), quality‐adjusted life‐years (QALYs), and incremental cost‐effectiveness ratios (ICERs).ResultsIpilimumab with nivolumab was the most effective strategy (10.69 life‐years and 9.25 QALYs for the third line; 10.69 life‐years and 9.44 QALYs for the first line) in comparison with nivolumab (8.21 life‐years and 6.76 QALYs for the third line; 8.21 life‐years and 7.00 QALYs for the first line), trifluridine and tipiracil (0.74 life‐years and 0.07 QALYs), and mFOLFOX6 and cetuximab (2.72 life‐years and 1.63 QALYs). However, neither checkpoint inhibitor therapy was cost‐effective in comparison with trifluridine and tipiracil (nivolumab ICER, $153,000; ipilimumab and nivolumab ICER, $162,700) or mFOLFOX6 and cetuximab (nivolumab ICER, $150,700; ipilimumab and nivolumab ICER, $158,700).ConclusionsThis modeling analysis found that both single and dual checkpoint blockade could be significantly more effective for MSI‐H/dMMR mCRC than chemotherapy, but they were not cost‐effective, largely because of drug costs. Decreases in drug pricing and/or the duration of maintenance nivolumab could make ipilimumab and nivolumab cost‐effective. Prospective clinical trials should be performed to explore the optimal duration of maintenance nivolumab.
Unstimulated Adult Human B Cells Include an IL‐10+ Population with Suppressive Properties and an Activated Phenotype
Authors: Šunina Marina , Kaleviste Epp , Uibo Raivo , Kisand Kai 
Published: October 2018

AbstractB cells with regulatory properties have been recently identified and described in different immune disorders, including autoimmunity, infection, cancer, and allergy. in vitro studies of regulatory B cells are usually performed following prolonged cell culture and stimulation in order to obtain B cells capable of IL‐10 secretion. We describe the isolation of viable IL‐10‐positive B cells directly from ex vivo unstimulated samples using the IL‐10 secretion assay from Miltenyi Biotec, which was originally designed for IL‐10‐positive T cell analysis and isolation. IL‐10‐positive B cells from unstimulated samples represented approximately 2% of all B cells in healthy individuals, suppressed T cell proliferation and were enriched for surface markers of B cell activation. This tool has a potential to boost functional studies of IL‐10‐secreting B cells in health and disease. © 2018 International Society for Advancement of Cytometry
A brief appraisal of computational modeling of antimicrobial peptides’ activity
Authors: Mondal Jagannath 
Published: October 2018

AbstractWe present a brief overview of computer simulations over the span of last two decades that have made some serious attempts in providing key insights toward the mechanistic aspects of antimicrobial peptides and biomimetic peptides. We review some of the success stories of computational modeling of antimicrobial activity and also point toward the present shortcomings of the current approaches. Finally, we shed light upon the future potential directions that computational approach can adopt toward direct and closer comparisons with experiments on antimicrobial activity.