bluuebunny/crossref_metadata_2025_split huggingface dataset:
White lupin (Lupinus albus) variation for adaptation to severe drought stress
Authors: Annicchiarico Paolo , Romani Massimo , Pecetti Luciano 
Published: September 2018

AbstractThis study aimed to reduce the gap of knowledge on white lupin drought tolerance variation, by assessing the grain yield of 21 landraces from major historical cropping regions, one variety and two breeding lines in a large phenotyping platform that imposed controlled severely stressed or moisture‐favourable conditions after an initial stage of favourable growth. Drought stress reduced grain yield by 79%. Genetic correlation coefficients indicated moderate consistency of genotype responses across conditions for grain yield (rg = 0.76), fairly high consistency for straw yield (rg = 0.85) and harvest index (rg = 0.91), and high consistency for flowering time (rg = 0.99). However, low genetic correlation for yield (rg = 0.31) occurred among a subset of genotypes with early phenology. Specific adaptation to either condition implied significant (p = 0.05) genotype × condition interaction of crossover type between well‐performing genotypes. Early flowering was an important stress escape mechanism, but intrinsic drought tolerance could be inferred from responses of a few genotypes. Various landraces out‐yielded the improved germplasm under stressed or favourable conditions.
Bronchiectasis: Treatment decisions for pulmonary exacerbations and their prevention
Authors: Bell Scott C. , Elborn Joseph S. , Byrnes Catherine A. 
Published: September 2018

ABSTRACTInterest in bronchiectasis has increased over the past two decades, as shown by the establishment of disease‐specific registries in several countries, the publication of management guidelines and a growing number of clinical trials to address evidence gaps for treatment decisions. This review considers the evidence for defining and treating pulmonary exacerbations, the approaches for eradication of newly identified airway pathogens and the methods to prevent exacerbations through long‐term treatments from a pragmatic practice‐based perspective. Areas for future studies are also explored.Watch the video abstract
Performance Analysis of Integrated Solar Tower With a Conventional Heat and Power Co-Generation Plant
Authors: Mokheimer Esmail M. A. , Dabwan Yousef N. 
Published: September 2018

Abstract
This paper presents the results of a thermo-economic analysis of integrating solar tower (ST) with heat and power cogeneration plants that is progressively being installed to produce heat and electricity to operate absorption refrigeration systems or steam for industrial processes. The annual performance of an integrated solar-tower gas-turbine-cogeneration power plant (ISTGCPP) with different sizes of gas turbine and solar collector's area have been examined and presented. Thermoflex + PEACE software's were used to thermodynamically and economically assess different integration configurations of the ISTGCPP. The optimal integrated solar field size has been identified and the pertinent reduction in CO2 emissions due to integrating the ST system is estimated. For the considered cogeneration plant (that is required to produce 81.44 kg/s of steam at 394 °C and 45.88 bars), the study revealed that (ISTGCPP) with gas turbine of electric power generation capacity less than 50 MWe capacities have more economic feasibility for integrating solar energy. The levelized electricity cost (LEC) for the (ISTGCPP) varied between $0.067 and $0.069/kWh for gas turbine of electric power generation capacity less than 50 MWe. Moreover, the study demonstrated that (ISTGCPP) has more economic feasibility than a stand-alone ST power plant; the LEC for ISTGCPP is reduced by 50–60% relative to the stand-alone ST power plant. Moreover, a conceptual procedure to identify the optimal configuration of the ISTGCPP has been developed and presented in this paper.
Prevalence and causes of vision loss in North Africa and Middle East in 2015: magnitude, temporal trends and projections
Authors: Kahloun Rim , Khairallah Moncef , Resnikoff Serge , Cicinelli Maria Vittoria , Flaxman Seth R , Das Aditi , Jonas Jost B , Keeffe Jill E , Kempen John H , Leasher Janet , Limburg Hans , Naidoo Kovin , Pesudovs Konrad , Silvester Alexander J , Tahhan Nina , Taylor Hugh R , Wong Tien Yin , Bourne Rupert R A 
Published: September 2018

BackgroundTo assess the prevalence and causes of vision impairment in North Africa and the Middle East (NAME) from 1990 to 2015 and to forecast projections for 2020.MethodsBased on a systematic review of medical literature, the prevalence of blindness (presenting visual acuity (PVA) <3/60 in the better eye), moderate and severe vision impairment (MSVI; PVA <6/18 but ≥3/60) and mild vision impairment (PVA <6/12 but ≥6/18) was estimated for 2015 and 2020.ResultsThe age-standardised prevalence of blindness and MSVI for all ages and genders decreased from 1990 to 2015, from 1.72 (0.53–3.13) to 0.95% (0.32%–1.71%), and from 6.66 (3.09–10.69) to 4.62% (2.21%–7.33%), respectively, with slightly higher figures for women than men. Cataract was the most common cause of blindness in 1990 and 2015, followed by uncorrected refractive error. Uncorrected refractive error was the leading cause of MSVI in the NAME region in 1990 and 2015, followed by cataract. A reduction in the proportions of blindness and MSVI due to cataract, corneal opacity and trachoma is predicted by 2020. Conversely, an increase in the proportion of blindness attributable to uncorrected refractive error, glaucoma, age-related macular degeneration and diabetic retinopathy is expected.ConclusionsIn 2015 cataract and uncorrected refractive error were the major causes of vision loss in the NAME region. Proportions of vision impairment from cataract, corneal opacity and trachoma are expected to decrease by 2020, and those from uncorrected refractive error, glaucoma, diabetic retinopathy and age-related macular degeneration are predicted to increase by 2020.
Pupillary light reaction in preclinical Alzheimer’s disease subjects compared with normal ageing controls
Authors: Van Stavern Gregory P , Bei Ling , Shui Ying-Bo , Huecker Julie , Gordon Mae 
Published: September 2018

Background/aimsWe wished to determine whether the pupillary light reaction can differentiate preclinical Alzheimer’s disease (AD) subjects from normal ageing controls. We performed a prospective study evaluating the pupillary light reaction in a cohort of well-characterised subjects with preclinical AD versus normal ageing controls.MethodsWe recruited 57 subjects from our institution’s Memory and Aging Project, part of our Alzheimer’s Disease Research Center. All subjects completed PET-PiB imaging, cerebrospinal fluid analysis and at least 1 neuropsychiatric assessment after their baseline assessment. All participants were assigned a clinical dementia rating and underwent a complete neuro-ophthalmic examination. Participants were divided into a dementia biomarker+ (preclinical AD) and biomarker– (normal ageing) group based on preclinical risk for Alzheimer’s dementia. Pupillometry measurements were performed by using the NeurOptics PLR-200 Pupillometer.ResultsA total of 57 subjects were recruited with 24 dementia biomarker+ and 33 dementia biomarker- individuals. A variety of pupil flash response (PLR) parameters were assessed. Comparisons between groups were analysed using generalised estimating equations. None of the pupillary parameters showed a significant difference between groups.ConclusionsWe found no significant differences in PLR between preclinical AD subjects and normal ageing controls. This suggests that the disease effect on the PLR may be small and difficult to detect at the earliest stages of the disease. Future studies could include larger sample size and chromatic pupillometry.
Association of peripartum troponin I levels with left ventricular relaxation in women with hypertensive disorders of pregnancy
Authors: Umazume Takeshi , Yamada Satoshi , Yamada Takahiro , Ishikawa Satoshi , Furuta Itsuko , Iwano Hiroyuki , Murai Daisuke , Hayashi Taichi , Okada Kazunori , Morikawa Mamoru , Tsutsui Hiroyuki , Minakami Hisanori 
Published: September 2018

ObjectiveWomen with hypertensive disorders of pregnancy (HDP) show elevated risk of heart failure despite decreased circulating plasma volume compared with those with normotensive control pregnancies (NCP). This study was performed to better characterise the heart in women with HDP and determine whether high-sensitivity troponin I (hs-TnI) around childbirth predicts reduced left ventricular (LV) relaxation at 1 month postpartum.MethodsEchocardiography was performed longitudinally during the first, second and third trimesters and immediately postpartum within 1 week and 1 month postpartum in 24 women with HDP, with simultaneous determination of blood variables in comparison with 51 women with NCP.ResultsCompared with NCP, HDP showed greater antepartum left atrial (LA) volume, LV mass and inferior vena cava (IVC) diameter, higher peripartum brain natriuretic peptide/N-terminal pro–B-type natriuretic peptide and hs-TnI with the highest value immediately postpartum, and lower early diastolic mitral annular velocity (e') during pregnancy/postpartum. In analyses of data on HDP and NCP, hs-TnI at the third trimester as well as that immediately postpartum was negatively correlated with later e' at 1 month postpartum. The areas under the receiver operating characteristic curves were 0.82 and 0.81 for hs-TnI at the third trimester and immediately postpartum, respectively, in the prediction of reduced LV relaxation at 1 month postpartum.ConclusionReduced LV diastolic function and decreased splanchnic blood reservoir may contribute to the increased third trimester IVC diameter and LA volume in women with HDP. The rise in hs-TnI around childbirth was associated with poor LV relaxation ability at 1 month postpartum.
Devonian (
c.
388–375 Ma) Horn River Group of Mackenzie Platform (NW Canada) is an open-shelf succession recording oceanic anoxic events
Authors: Kabanov P. 
Published: September 2018

At least four horizons of enhanced anoxia (anoxic horizons; AHs) are recognized in the uppermost Eifelian–Middle Frasnian mudrock-dominated strata of the Mackenzie Valley and Peel area of NW Canada. Aluminium-normalized Mo and U logs in two cored sections reveal AH-I at the Eifelian–Givetian boundary, AH-II in basal Frasnian, and AH-III and AH-IV bundled in the Middle Frasnian interval. These four horizons are characterized by attenuated siliciclastic components. Spectral gamma-ray K + Th and U are the best tools to trace these horizons in wells and outcrops. AHs are biostratigraphically correlated with ‘black-shale events’ in several basins of the world. Depositional environment is depicted as a stratified basin where the water-column chemocline defined co-sedimentation of anoxic mudrocks in topographic lows and oxic grey shales and carbonate banks on seafloor elevations. Based on inductively coupled plasma elemental data from 1687 samples, siliciclastic-lean basinal mudrock units that host AHs are strongly enriched in Mo (median EFMo ∼ 97–172 EFMo/EFU ≈ (3–3.5) × SW, where EFMo and EFU are respectively Al-normalized Mo and U in enrichment factor notation and SW is average present-day seawater value) compared with siliciclastic-rich units (median EFMo ∼ 17–37) and show strong EFU/EFMo covariation (
r
≈ 0.8 in Canol Formation and Bluefish Member). Supported by a lack of geological evidence for an oceanographic barrier, this enrichment indicates unrestricted water exchange with Panthalassa. At the same time, development of oligotrophy is indicated by a lack of P enrichment and weak to non-existent enrichment in Zn and Cu. These features are reconciled through a model by earlier workers that involves a global shift to a warm greenhouse mode with slowed oceanic convection, expanded oxygen minimum zones and a failure of nutrient resupply from the upwelling. The onset of mass degassing in continental large igneous provinces represents a potential trigger for this mid-Devonian shift. Devonian black-shale events in this scenario represent genuine oceanic anoxic events marking hothouse episodes in their nascent form.

Supplementary material:
Details of methods, analytical protocols and data scatterplots, stratigraphic cross-sections showing traceability of anoxic horizons, and inductively coupled plasma elemental and Rock-Eval 6 data used in this study are available at:
https://doi.org/10.6084/m9.figshare.c.4212428
Timing of subduction initiation, arc formation, ophiolite obduction and India–Asia collision in the Himalaya
Authors: Searle Michael P. 
Published: September 2018

Abstract

Reconstruction of the Western Himalaya requires three subduction systems operating beneath the Spong arc, Dras–Kohistan arc and the Asian continent during the Late Cretaceous–Paleocene. The timing of the closure of the Neo-Tethys Ocean along the Indus Suture Zone (ISZ) in Ladakh and south Tibet has been proposed to be as old as
c.
65 Ma and as young as
c.
37 Ma. The definition of the India–Asia collision can span >15 myr from the first touching of Indian continental crust with Asian crust to the final marine sedimentation between the two plates. There is good geological evidence for a Late Cretaceous–Early Paleocene phase of folding, thrusting and crustal thickening of Indian Plate shelf carbonates associated with obduction of ophiolites. There is no geological evidence of any oceanic ‘Greater Indian Basin’ separating the northern Tethyan and Greater Himalaya from India. There is clear evidence to support final ending of marine sedimentation along the ISZ at 50 Ma (planktonic foraminifera zone P7–P8). There is no evidence for diachroneity of collision along the Pakistan–Ladakh–South Tibet Himalaya. The timing of ultrahigh-pressure metamorphism cannot be used to constrain India–Asia collision, and the timing of high-grade kyanite- and sillimanite-grade metamorphism along the Greater Himalaya can only give a minimum age of collision.
Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma
Authors: Kalaora Shelly , Wolf Yochai , Feferman Tali , Barnea Eilon , Greenstein Erez , Reshef Dan , Tirosh Itay , Reuben Alexandre , Patkar Sushant , Levy Ronen , Quinkhardt Juliane , Omokoko Tana , Qutob Nouar , Golani Ofra , Zhang Jianhua , Mao Xizeng , Song Xingzhi , Bernatchez Chantale , Haymaker Cara , Forget Marie-Andrée , Creasy Caitlin , Greenberg Polina , Carter Brett W. , Cooper Zachary A. , Rosenberg Steven A. , Lotem Michal , Sahin Ugur , Shakhar Guy , Ruppin Eytan , Wargo Jennifer A. , Friedman Nir , Admon Arie , Samuels Yardena 
Published: September 2018

Abstract
The quest for tumor-associated antigens (TAA) and neoantigens is a major focus of cancer immunotherapy. Here, we combine a neoantigen prediction pipeline and human leukocyte antigen (HLA) peptidomics to identify TAAs and neoantigens in 16 tumors derived from seven patients with melanoma and characterize their interactions with their tumor-infiltrating lymphocytes (TIL). Our investigation of the antigenic and T-cell landscapes encompassing the TAA and neoantigen signatures, their immune reactivity, and their corresponding T-cell identities provides the first comprehensive analysis of cancer cell T-cell cosignatures, allowing us to discover remarkable antigenic and TIL similarities between metastases from the same patient. Furthermore, we reveal that two neoantigen-specific clonotypes killed 90% of autologous melanoma cells, both in vitro and in vivo, showing that a limited set of neoantigen-specific T cells may play a central role in melanoma tumor rejection. Our findings indicate that combining HLA peptidomics with neoantigen predictions allows robust identification of targetable neoantigens, which could successfully guide personalized cancer immunotherapies.
Significance: As neoantigen targeting is becoming more established as a powerful therapeutic approach, investigating these molecules has taken center stage. Here, we show that a limited set of neoantigen-specific T cells mediates tumor rejection, suggesting that identifying just a few antigens and their corresponding T-cell clones could guide personalized immunotherapy. Cancer Discov; 8(11); 1366–75. ©2018 AACR.
This article is highlighted in the In This Issue feature, p. 1333
The Scribe of 1QS, 1QSa, 1QSb, 4Q53 (4QSamc), 4Q175 and Three Features of Orthography and Phonology
Authors: Reymond Eric D. 
Published: September 2018

Abstract
That a single scribe copied 1QS, 1QSa, 1QSb, 4Q53 (4QSamc), 4Q175 is commonly recognized. However, what has not been emphasized previously is that certain orthographic / phonological idiosyncrasies appear prominently, if not exclusively, in only one of these texts, 1QS, even though these idiosyncrasies would seem to be involuntary and, for this reason, should appear evenly distributed throughout the texts. Instead, one finds the greatest correspondence in type and concentration in 1QIsaa, though this was copied by different scribes. The three idiosyncratic features studied are the Aramaic והי- suffix on plural nouns, the he in the prefix of hiphil yiqṭol verbs, and the interchange of gutturals.
Morphometric characteristics of Alpine salamanders: a support for subspecies validation and conservation?
Authors: Šunje Emina , Van Damme Raoul , Jelić Dušan , Mueller Maria , Škrijelj Rifat , Helfer Véronique 
Published: September 2018

Abstract
The subspecies concept is not only useful to assess the evolutionary history of species and therefore describe their evolutionary potential, but it also has corollaries for defining conservation units and their management. Within Alpine salamanders, the subspecies status of Salamandra atra prenjensis, isolated in the Dinarides from its nominal subspecies Salamandra atra atra that occurs in the Alps, has been under debate. To remediate this fuzzy taxonomy, the present study investigates 14 morphological traits of Alpine salamanders originating from Austria and from Bosnia and Herzegovina (B&H). Multivariate analyses support a geographical structuring of morphological variation and the differentiation between the Dinaric (B&H) and Alpine (Austrian) populations. Within populations, a different correlation pattern among traits is registered, reflecting the distinct genetic architecture of multivariate phenotypes. This morphometric study supports recent molecular evidences of a strong differentiation between the Dinaric and Alpine populations and pleads in favour of the separate subspecies status, although a wider sampling of other populations and the inclusion of additional characters would be necessary to reinforce this conclusion. The recognition of Salamandra atra prenjensis as a distinct subspecies would highly contribute to the better conservation of this emblematic salamander.
Comparison of GPM Core Observatory and Ground-Based Radar Retrieval of Mass-Weighted Mean Raindrop Diameter at Midlatitude
Authors: D’Adderio Leo Pio , Vulpiani Gianfranco , Porcù Federico , Tokay Ali , Meneghini Robert 
Published: September 2018

Abstract
One of the main goals of the National Aeronautics and Space Administration (NASA) Global Precipitation Measurement (GPM) mission is to retrieve parameters of the raindrop size distribution (DSD) globally. As a standard product of the Dual-Frequency Precipitation Radar (DPR) on board the GPM Core Observatory satellite, the mass-weighted mean diameter Dm and the normalized intercept parameter Nw are estimated in three dimensions at the resolution of the radar. These are two parameters of the three-parameter gamma model DSD adopted by the GPM algorithms. This study investigates the accuracy of the Dm retrieval through a comparative study of C-band ground radars (GRs) and GPM products over Italy. The reliability of the ground reference is tested by using two different approaches to estimate Dm. The results show good agreement between the ground-based and spaceborne-derived Dm, with an absolute bias being generally lower than 0.5 mm over land in stratiform precipitation for the DPR algorithm and the combined DPR–GMI algorithm. For the DPR–GMI algorithm, the good agreement extends to convective precipitation as well. Estimates of Dm from the DPR high-sensitivity (HS) Ka-band data show slightly worse results. A sensitivity study indicates that the accuracy of the Dm estimation is independent of the height above surface (not shown) and the distance from the ground radar. On the other hand, a nonuniform precipitation pattern (interpreted both as high variability and as a patchy spatial distribution) within the DPR footprint is usually associated with a significant error in the DPR-derived estimate of Dm.
Contribution of 18F-FDG PET/CT in a case-mix of fever of unknown origin and inflammation of unknown origin: a meta-analysis
Authors: Kan Ying , Wang Wei , Liu Jie , Yang Jigang , Wang Zhenchang 
Published: September 2018

Background Fever of unknown origin (FUO) and inflammation of unknown origin (IUO) are challenging medical problems. Previous studies have shown that 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) plays an important role in the diagnosis of FUO, but few studies have explored this diagnostic technique in relation to IUO. Purpose To systematically review and perform a meta-analysis of published data on the diagnostic performance of PET/CT in the diagnosis of FUO and IUO. Material and Methods A comprehensive literature search was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines published in March 2018. Meta-analysis of diagnostic performance was performed using STATA 12.0 software. Subgroup analysis was performed by stratification based on study design, number of patients, geographic area, and final diagnosis based on 18F-FDG PET/CT. Meta-regression analyses were performed to recognize heterogeneity. Results Our meta-analysis included 23 studies, comprising a total sample size of 1927 patients. The pooled diagnosis performance was calculated with a per-patient-based analysis: sensitivity = 0.84 (95% confidence interval [CI] = 0.79–0.89), specificity = 0.63 (95% CI = 0.49–0.75), positive likelihood ratio = 2.3 (95% CI = 1.5–3.4), negative likelihood ratio = 0.25 (95% CI = 0.16–0.38), diagnostic odds ratio = 9 (95% CI = 4.0–20), and AUC = 0.84 (95% CI = 0.81–0.87). Conclusion In patients with non-specific symptoms and signs, 18F-FDG PET/CT is very helpful for recognizing and excluding diseases, directing further diagnostic decisions, and avoiding unnecessary invasive examinations. We recommend that 18F-FDG PET/CT should be considered among the first-line diagnostic tools for patients with FUO and IUO.