bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lateral ventricle volume trajectories predict response inhibition in older age - a longitudinal brain imaging and machine learning approach
Authors: Lundervold Astri J. , Vik Alexandra , Lundervold Arvid 
Published: November 2018

AbstractObjective:In a three-wave ~6 yrs longitudinal study we investigated if expansion of lateral ventricle (LV) volumes (regarded as a proxy for brain parenchyma loss) predicts performance on a test of response inhibition.Participants and Methods:Anatomical trajectories of left (LH) and right (RH) lateral ventricle volumes across the three study-waves were quantified using the Longitudinal Stream in Freesurfer 5.3 and modelled using a linear mixed-effects (LME) algorithm. All participants (N = 74, mean age 60.7 yrs at inclusion, 48 females) performed the Color-Word Interference Test (CWIT). Response time on the third condition was used as a measure of response inhibition (RI) and divided into three classes (fast, medium and slow). The Extreme Gradient Boosting (XGBoost) algorithm was used for calculating the relative importance of selected LV volume features from the LME model in predicting RI class. Finally, the two most important extracted features were fed into a 10-fold cross-validation framework, estimating the accuracy, precision and recall of the RI class prediction.Results:Four LME based features were selected to characterize LV volume trajectories: steepness of LV volume change and the LV volume at the time of inclusion, each from the right and left hemisphere. The XGBoost procedure selected the steepness measure from the right and the volume at inclusion from the left hemisphere as the two most important features to predict RI performance. The 10-fold cross validation procedure showed a recall, precision and accuracy score (.40 - .50) that were clearly above chance level.Conclusion:Measures of the LV volume trajectories gave a fairly good prediction of response inhibition performance, confirming the role of LV volume as a biomarker of cognitive function in older adults. Future studies should investigate the value of the lateral ventricle volume trajectories as predictors of cognitive preservation or decline into older age.
Associations between impulsivity, risk behavior and HIV, HBV, HCV and syphilis seroprevalence among female prisoners in Indonesia: A cross-sectional study
Authors: Arends Rachel M. , Nelwan Erni J. , Soediro Ratna , van Crevel Reinout , Alisjahbana Bachti , Pohan Herdiman T. , von Borries A. Katinka L. , Schene Aart H. , van der Ven André J. A. M. , Schellekens Arnt F. A. 
Published: November 2018

AbstractHIV, hepatitis B and C, and syphilis share common transmission routes of which primarily unsafe sexual contact and injecting drug use are important. Impulsivity is a major factor contributing to this transmission risk behavior, however comprehensive studies within female, prison, and Asian populations are scarce. This cross-sectional study aims to delineate the contributions of different aspects of impulsivity to transmission risk behavior, among female inmates living in a prison in Jakarta (N=214). The relationships between various aspects of impulsivity, risky behavior and seropositivity were tested using analyses of variance and logistic regression analyses. Motor impulsivity was related to alcohol use, reward-related impulsivity to drug use, and cognitive/goal-directed impulsivity to sexual risk behavior. Finally, goal-directed impulsivity was also directly associated with seropositivity. Specific aspects of impulsivity are associated with different types of risky behaviors in Indonesian female prisoners, what can be relevant for future studies on infection prevention strategies for such a population.
Hashimoto’s Thyroiditis-associated Thyroid Swelling among Adolescents Presenting with Benign Goiter in Lahore, Pakistan
Authors: Shan Saira , Aslam Shumaila , Elahi Shan , Rizvi Nayab Batool , Saleem Nazish 
Published: November 2018

AbstractBackgroundThe aim of this study was to determine frequency of Hashimoto’s thyroiditis (HT), by determination of serum TPO-Ab titer in goitrous adolescents attending Centre for Nuclear Medicine (CENUM), Mayo Hospital, Lahore, Pakistan.MethodSerum TPO-Ab was determined in 277 local goitrous adolescents (female 194, male 83) with euthyroidism or subclinical hypothyroidism. Their mean (±SD) age was 15.8 + ***2.5 years with age range 10 to 19 year. Female and male adolescents were comparable in age, goiter size and serum thyroid hormone levels.ResultsMean TSH and percentage of TSH levels > 3.0 mIU/L was significantly higher in male adolescents. High serum TPO-Ab titer (> 20.0 IU/ml) or HT was detected in 38 (13.7%) patients. The incidence of HT in female (16.5%) was higher than male adolescents (7.2%) but the difference was not statistically significant (p=0.120). Similarly goiter size (palpable or visible) or patient age (below or above 16 year) has no significant effect on HT frequency. However, compared to adolescents with TSH within normal laboratory range those with TSH level above the upper normal limit (4.0 mIU/L) had significantly more frequency of HT (10.4% versus 30.4%; p=0.001).ConclusionThus this study reports 13.7% prevalence of HT-associated goiter among local adolescents presenting with benign goiter, in Lahore Pakistan.
ICT-based innovation and its competitive outcome: the role of information intensity
Authors: Neirotti Paolo , Pesce Danilo 
Published: November 2018

PurposePrior research highlights the vital role of Information and Communication Technologies (ICT) for innovation in response to environmental conditions. However, there is a lack of studies that analyse the determinants of ICT investments on the innovation activities of firms in relation with their impacts on the industrial and competitive dynamics using large data sets. The paper aims to discuss these issues.Design/methodology/approachIn this paper, the authors investigate the effects of ICT investments on the industrial and competitive dynamics for a large and representative panel data set. All the industries are included, and lagged effects of ICT investments are studied. The model is tested on a seven-year panel (2008–2014) of 231 Italian industries using two-stage least squares instrumental-variables estimators with industry time and fixed effects.FindingsThe results indicate that munificent industries and higher ICT spending are interrelated facts, showing that in sectors with more growth opportunities firms invest more in ICT and this leads to higher industry concentration, greater profit dispersion and higher competitive turbulence in the sector. Also, the paper shows that SMEs can rarely take advantage of their ICT-based innovation to start high-growth phenomena.Practical implicationsThe results suggest that ICT-based innovation may create competitive advantages that are hard to sustain over the long-term raising important implications for managers involved in ICT-enabled innovations and policy-makers involved in building programs to foster innovation.Originality/valueAgainst the backdrop of today’s digital transformation, the paper enriches our understanding on the disruptive effects exerted by the digitalization of the innovation process and provides a base to continue the investigation of industrial changes and competitive dynamics.
Global identity, perceptions of luxury value and consumer purchase intention: a cross-cultural examination
Authors: Yang Jie , Ma Jieqiong , Arnold Mark , Nuttavuthisit Krittinee 
Published: November 2018

Purpose
In today’s highly globalized marketplace, it is increasingly important to understand why some consumers prefer luxury goods. This study aims to further explore the relationship between consumers’ global identity, their perceived functional, individual and social value of luxury and their intentions to purchase luxury.

Design/methodology/approach
Samples from two substantially different cultures, the USA and China, were used to explore the proposed relationships in an intercultural context. Established scales were adapted to measure each of the constructs of interest. The final sample includes 295 US and 247 Chinese participants.

Findings
By using samples from the USA and China, this study finds that global identity is positively related to purchase intention of luxury products, mediated by perceived functional, individual and social value of luxury.

Originality/value
Drawing insights from self-verification theory, this research provides a three-path framework to expand the knowledge of consumers’ motivation to purchase luxury.
Evidence of leverage effects and volatility spillover among exchange rates of selected emerging and growth leading economies
Authors: Panda Ajaya Kumar , Nanda Swagatika , Singh Vipul Kumar , Kumar Satish 
Published: November 2018

Purpose
The purpose of this study is to examine the evidences of leverage effects on the conditional volatility of exchange rates because of asymmetric innovations and its spillover effects among the exchange rates of selected emerging and growth-leading economies.

Design/methodology/approach
The empirical analysis uses the sign bias test and asymmetric generalized autoregressive conditional heteroskedasticity (GARCH) models to capture the leverage effects on conditional volatility of exchange rates and also uses multivariate GARCH (MGARCH) model to address volatility spillovers among the studied exchange rates.

Findings
The study finds substantial impact of asymmetric innovations (news) on the conditional volatility of exchange rates, where Russian Ruble is showing significant leverage effect followed by Indian Rupee. The exchange rates depict significant mean spillover effects, where Rupee, Peso and Ruble are strongly connected; Real, Rupiah and Lira are moderately connected; and Yuan is the least connected exchange rate within the sample. The study also finds the assimilation of information in foreign exchanges and increased spillover effects in the post 2008 periods.

Practical implications
The results probably have the implications for international investment and asset management. Portfolio managers could use this research to optimize their international portfolio. Policymakers such as central banks may find the study useful to monitor and design interventions strategies in foreign exchange markets keeping an eye on the nature of movements among these exchange rates.

Originality/value
This is one of the few empirical research studies that aim to explore the leverage effects on exchange rates and their volatility spillovers among seven emerging and growth-leading economies using advanced econometric methodologies.
Publishing speed and acceptance rates of open access megajournals
Authors: Björk Bo-Christer 
Published: November 2018

PurposeThe purpose of this paper is to look at two particular aspects of open access megajournals, a new type of scholarly journals. Such journals only review for scientific soundness and leave the judgment of scientific impact to the readers. The two leading journals currently each publish more than 20,000 articles per year. The publishing speed of such journals and acceptance rates of such journals are the topics of the study.Design/methodology/approachSubmission, acceptance and publication dates for a sample of articles in 12 megajournals were manually extracted from the articles. Information about acceptance rates was obtained using web searches of journal home pages, editorials, blogs, etc.FindingsThe time from submission to publication varies a lot, with engineering megajournals publishing much more rapidly. But on average it takes almost half a year to get published, particularly in the high-volume biomedical journals. As some of the journals have grown in publication volume, the average review time has increased by almost two months. Acceptance rates have slightly decreased over the past five years, and are now in the range of 50–55 percent.Originality/valueThis is the first empirical study of how long it takes to get published in megajournals and it highlights a clear increase of around two months in publishing. Currently, the review process in the biomedical megajournals takes as long as in regular more selective journals in the same fields. Possible explanations could be increasing difficulties in finding willing and motivated reviewers and in a higher share of submissions from developing countries.
Money as a social relation beyond the state: a contribution to the institutionalist approach based on the Argentinian trueque
Authors: Saiag Hadrien 
Published: November 2018

AbstractThis paper provides a contribution to the institutionalist approach to money through ethnographic research carried out in two local currency systems in Argentina (known as trueque). It argues that Argentinian local currencies must be considered as monies in their own right even if they differ from state and bank issued currencies, because they can be understood as systems of evaluation and settlement of debts denominated in a specific unit of account (the crédito). Money is said to be an ambivalent social relation because in the two cases studied it mediates very different dynamics, exacerbating inequality in one context and promoting collective emancipation in another. This difference is due to the kind of political communities that the crédito tends to forge. In both Rosario and Poriajhu, the political community is defined by a set of values that legitimizes ongoing monetary practices and institutions rather than the State’s coercion.
Rebound pain following peripheral nerve block anaesthesia in acute ankle fracture surgery: An exploratory pilot study
Authors: Sort Rune , Brorson Stig , Gögenur Ismail , Nielsen Jesper K. , Møller Ann M. 
Published: November 2018

BackgroundPeripheral nerve blocks (PNB) are increasingly used for anaesthesia and postoperative pain control in acute orthopaedic limb surgery but rebound pain upon cessation of PNBs may challenge the benefits on the pain profile. We aimed to explore the pain profile following acute ankle fracture surgery under PNB anaesthesia and investigate if rebound pain could pose a clinical problem.MethodsExploratory, observational study of adults scheduled for acute primary internal fixation of an ankle fracture under ultrasound‐guided popliteal sciatic and saphenous ropivacaine block anaesthesia. Postoperatively, patients regularly registered pain scores while receiving a fixed analgesics regimen and patient controlled morphine on‐demand. We analysed morphine consumption and depicted the detailed pain profiles as graphs allowing for visual analysis of pain courses, including rebound pain. Secondly, we compared the area under the curve and peak pain between relevant age‐subgroups.ResultsWe included 21 patients aged 20‐83. Depicted pain profiles reveal that PNB supplied effective and long lasting postoperative pain control, but cessation of the PNB led to intense rises in pain scores with six out of nine 20‐60‐year‐olds reaching severe pain levels. The rebound was less pronounced in patients >60 years old, but nearly all reached moderate pain levels. Morphine consumption rates were high during the rebound.ConclusionsThis study thoroughly analyses the post‐PNB pain profile and suggests rebound pain is a clinically relevant and problematic issue with the potential to outweigh the PNB benefits, especially for younger patients. The conclusions are tentative, and a randomised study is pending.
Supervised exercise training with multimodal pre‐habilitation leads to earlier functional recovery following colorectal cancer resection
Authors: Awasthi Rashami , Minnella Enrico M. , Ferreira Vanessa , Ramanakumar Agnihotram V. , Scheede‐Bergdahl Celena , Carli Francesco 
Published: November 2018

BackgroundExercise training is a component of the pre‐habilitation program. While in one previous study the training was home‐based, in a subsequent investigation it was supervised in hospital. The hypothesis of this secondary analysis of the two studies was to determine whether supervised exercise further accelerates the return to baseline walking ability.MethodsData from two consecutive randomized control trials (RCT) comparing pre‐habilitation to the rehabilitation of cancer patients scheduled for colorectal surgery were pooled for analysis. The interventions were similar and included home‐based exercise training, nutritional counseling and protein supplementation, and relaxation techniques administered either before surgery (pre‐habilitation) or after surgery (rehabilitation). Patients in the second RCT received additional supervised exercise sessions. Functional capacity was assessed with the 6‐minute walk test (6 MWT) at baseline, before surgery, and at 4 and 8 weeks after surgery. Adjusted logistic regression was used to determine the improvement of the 6‐minute walk distance (6MWD).ResultsBaseline mean 6MWD of 63 patients in the supervised group was 465.1 m (SD, 115), and that of 77 patients in the nonsupervised group was 407.8 m (SD, 109) (P < 0.01). Perioperative supervised exercise training enhanced further functional capacity and muscle strength when compared with the nonsupervised group (P < 0.01). Those receiving exercise supervision had over two times higher chances to return to baseline after surgery. Supervised pre‐habilitation was the best combination (4 weeks OR = 7.71, and at 8 weeks OR = 8.62).ConclusionSupervised exercise training leads to meaningful changes in functional capacity thus accelerating the postoperative return to baseline activities.
Use of acronyms in anaesthetic and associated investigations: appropriate or unnecessary? – the UOAIAAAIAOU Study
Authors: Weale J. , Soysa R. , Yentis S. M. 
Published: November 2018

SummaryWe examined the prevalence of novel acronyms in the titles of anaesthetic and related studies and the response of anaesthetists to them. We separately analysed trainee‐led research projects in the UK supported by the Research and Audit Federation of Trainees (RAFT), and a 10‐year cohort of papers identified using the PubMed literature search tool. We also conducted a survey of 20 anaesthetists within our institution regarding the utility and impact of titles containing acronyms, and their recall of the associated topics. Finally, we developed a scoring system for acronym accuracy and complexity, the ORigin of AcroNym letterinG Used Term AppropriateNess (ORANGUTAN) score, and measured the progression of acronym usage over the 10‐year period studied. Our results show that while acronyms themselves are sometimes considered memorable, they do not aid recall of topics and are, in general, not considered helpful. There has been an increase in the prevalence of acronymic titles over 10 years, and in the complexity of acronyms used, suggesting that there is currently a selective pressure favouring the use of acronyms even if they are of limited benefit.
Elevated fetal haemoglobin levels are associated with decreased incidence of retinopathy in adults with sickle cell disease
Authors: Mian Umar K. , Tang Joyce , Allende Ana P. M. , Heo Moonseong , Bernstein Nicole , Vattappally Leena , Schoenfeld Daniel , Minniti Caterina P. 
Published: November 2018

SummaryAmong the many vascular complications of sickle cell disease (SCD), retinopathy is the most prevalent and represents a leading cause of blindness. Hydroxycarbamide therapy ameliorates many symptoms of SCD, and high fetal haemoglobin (HbF) levels have been shown to protect against the development of retinopathy in children with HbSS. Its effect on adults with SCD, who are at a much higher risk of developing retinopathy, has not been studied. We aimed to investigate the effect of hydroxycarbamide use and HbF level on sickle cell retinopathy development in adults. We performed a retrospective cross‐sectional study and collected demographics, comorbidities, and ocular and haematological data from 300 adult sickle cell subjects examined at the Henkind Eye Institute at Montefiore Medical Center during a 5‐year period, from October 2012 to November 2017. The cohort was comprised mainly of Black and Hispanic subjects with all SCD genotypes, aged 18–71 years. Results show that in HbSS patients treated with hydroxycarbamide, those with retinopathy had significantly lower HbF levels compared to patients without retinopathy (P = 0·018). Our study identified the optimal HbF cut‐off point for retinopathy protection to be 14·87%. Thus, a HbF level of 15% appears to be the threshold above which the odds for developing retinopathy in SS patients are reduced by 50%.
Prognostic impact of trisomy 21 in follicular lymphoma
Authors: Mitsui Takeki , Yokohama Akihiko , Koiso Hiromi , Saito Akio , Toyama Kohtaro , Shimizu Hiroaki , Ishizaki Takuma , Irisawa Hiroyuki , Takizawa Makiko , Saitoh Takayuki , Murayama Kayoko , Matsumoto Morio , Handa Hiroshi , Hirato Junko , Kojima Masaru , Murakami Hirokazu , Tsukamoto Norifumi 
Published: November 2018

SummaryThe chromosomal abnormalities associated with follicular lymphoma (FL) prognosis are not fully elucidated. Here, we evaluated the pattern of chromosomal abnormalities in FL, and clarified the correlations between the cytogenetic features and clinical outcome. Cytogenetic analysis was performed using standard methods of Giemsa‐banding at diagnosis for 201 FL patients admitted to our hospitals between 2001 and 2013. The identified chromosomal abnormalities were: t(14;18)(q32;q21) (59·2%), +X (17·9%), del(6)(q)/‐6 (16·9%), +7 (14·4%), abnormality of 1q12‐21/1q (12·9%), del(13)(q)/‐13 (11·9%), abnormality of 3q27 (10·4%), abnormality of 10q22‐24 (10·0%), +12/dup(12)(q) (10·0%), abnormality of 1p21‐22/1p (9·0%), +18 (9·0%), del(17)(p)/‐17 (5·0%), and a complex karyotype (54·7%). Patients with trisomy 21 had a significantly shorter progression‐free survival (P = 0·00171) and overall survival (OS) (P < 0·001) than those without trisomy 21; additionally, patients with trisomy 21 in the rituximab‐treated cohort also had a significantly shorter OS (P = 0·000428). Multivariate analysis identified trisomy 21 as an independent risk factor in our cohorts with or without t(14;18) (P = 0·015). In conclusion, the presence of trisomy 21 was an independent risk factor for in FL. Chromosomal analysis of FL patients at diagnosis can provide useful information about their expected survival.