bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimensões estatal, gerencial e individual da Política Nacional de Prevenção e Controle do Câncer (de Mama): um modelo avaliativo
Authors: Roque Ferreira Daiane Medeiros , Lima Afonso Augusto Teixeira de Freitas de Carvalho , Ferreira Marco Aurélio Marques 
Published: October 2019

O objetivo desse estudo foi evidenciar a existência de três dimensões teóricas condicionantes do desempenho na Política Nacional de Prevenção e Controle do Câncer (PNPCC), a saber: a dimensão estatal, em seu aparato legal e estrutural; a dimensão gerencial, por meio da capacidade gerencial municipal; e a dimensão individual, pelo envolvimento da sociedade com comportamentos difundidos pela política. Além disso, tem-se como proposta desenvolver um modelo para avaliar a PNPCC, o qual denominou-se de Modelo Sinérgico de Avaliação de Desempenho de Política Pública em Saúde (MoSADPPS). Para cumprir os objetivos propostos, foram adotados procedimentos metodológicos quantitativos como a Regressão Linear Logística e a Análise Fatorial. Os resultados confirmam a influência dessas três dimensões no resultado da PNPCC. Também encontrou-se que o melhor desempenho com a Política não está relacionado com melhores níveis de desenvolvimento econômico e social do município, mas possivelmente pela capacidade de gerenciar as políticas públicas de saúde.
Assessment of the Potential of Low-Salinity Water Injection Technology to Increase the Oil Recovery of the Carbonate Reservoir of the Kharyaga Field
Authors: Zoshchenko Oleg , Aleshchenko Anton , Trushin Yuri 
Published: October 2019

Abstract
The development of carbonate reservoirs using peripheral and pattern water flooding typically achieves oil recovery factors ranging from 0.3 to 0.5, which is due to some complicating factors, such as, oil-wet surface of the pore space or the surface with intermediate type of wetting, unfavorable ratio of oil and water viscosities, presence of extensive structure of fractures, and significant variations of permeability down the reservoir section. In a complex geological environment, wells display abrupt fluctuations of water production that is an evidence of formation water being by no means the most efficient displacement agent. In these conditions, low-salinity water flooding can improve oil recovery.
This paper reports on SCAL results of oil recovery factor determination and spontaneous imbibition using water with different composition and total solinity for Object 2 of Kharyaga oil field. Also, report contains design of on-site determination of residual oil saturation using Single Well Chemical Tracer test technology for evaluation of EOR efficiency.
Laboratory tests showed, that low-salinity Jurassic water flooding with total salinity about 5 g/l could rase recovery factor up to 4% and also give incremental recovery due to effects of spontaneous imbibition for permability lower than 100 mD, which makes the injection of Jurassic water more preferable.
Flexible Multi-Well Interference Test Design for a Deep-Water Field
Authors: Zubarev Denis , Mardanov Ruslan , Bochkarev Vitaly A. , Khmelevskij Vyacheslav 
Published: October 2019

Abstract
Interference testing is a common tool for addressing reservoir connectivity and compartmentalization risks. Due to the high costs of deep-water and ultra-deep-water extended well testing, this type of test is rarely performed during the appraisal phase and is usually postponed until the start of the field development. With the infrastructure in place, testing can be carried out with minimum planning and at a minimum cost. This is generally acceptable for fields with a lower subsurface complexity. However, for complex turbidite fields, this information becomes critical at the appraisal and early development planning stages to reduce the risks in depletion optimization and production infrastructure planning. To make testing practical, it has to be performed in a way that minimizes rig time and de-risks collection of required data.
To optimize the interference test design for the West Africa deep-water field appraisal phase, a simulation study was carried out to assess the impact of major uncertainties. A fine-scale 3D simulation model was used due to high heterogeneity and complex connectivity between individual channels and channel complexes. Impact of the drawdown rate, flow duration, tidal effect amplitude, OWC, faults transmissibility, absolute permeability, reservoir pore volume, and zones connectivity on interference time for different selections of test and observation wells were assessed through the sensitivity runs. Results were analyzed to get a better understanding of reservoir dynamic response such as pressure travel time and potential interference between zones.
Based on this study a flexible interference test plan was defined that ensures optimal rig use and minimal risk of sub-optimal dataset collection. This plan embeds both pre-test decisions and real-time decisions that depend on early time observations. An optimal test and observation wells setup that provides a balance between the rig time and value of information will depend on the planned appraisal well results and is one of the decisions to be finalized before the test. However, decisions on flow duration adjustment and consequent data monitoring in the observation wells will be made based on a set of early time events identified from the sensitivity of pressure interference response between different zones and wells.
The proposed uncertainty driven approach provides an obvious advantage over the common test design based on the "best technical estimate" model. It also provides a better basis for test feasibility decision and cost-effective implementation.
Application of Hybrid DPDP-DFN Modeling of Fractured Carbonate Reservoirs
Authors: Shevko Nikolay , Shaislamov Vil , Savelev Oleg 
Published: October 2019

Abstract
Predicting naturally fractured carbonate reservoir behavior is associated with fluid flow modeling of two and more mediums. Presence of highly conductive faults and fractures complicates the process. These complications are generally addressed by common approaches using DPDP models and modern techniques of explicit discrete fracture networks (DFN) modeling.
Dual porosity-dual permeability (DPDP) models do not provide proper results without significant modifications and improvements. Flow simulation of the whole fracture set in discrete format on full-scale models is computationally intensive and time-consuming task thus not applicable for practical purposes.
Alternative hybrid modeling approach based on combination of individual DFN objects (faults and long fractures) with traditional DPDP modeling was created based on detailed geological static model. Full scope of available geological, geophysical and production data was used to provide background for flow simulations.
Numeric algorithms were optimized for three mediums including single porosity medium (SPM), fracture medium (DFN) and discrete objects representing irregular fault and long fracture systems.
Generalized workflows for creating static model, defining fractured zones and explicit discrete objects, followed by DPDP-DFN hybrid modeling are described in this paper.
The proposed approach was utilized to perform full-scale model history matching, optimize well locations, estimate risks and uncertainties of gas injection efficiency.
Impact of intestinal helminth infections on malnutrition and haematological indices of school-age children in Gondar town, Ethiopia.Impact of intestinal helminth infections on malnutrition and haematological indices of school-age children in Gondar town, Ethiopia.
Authors: Tarekegn Daniel , Birhanie Meseret , Lemma Wossenseged 
Published: October 2019

Abstract
Abstract
Background: In Ethiopia Stunting, underweight and wasting in school children are very common. The aim of this research was to evaluate the impact of intestinal helminthes and schistosomiasis on malnutrition, anaemia and haematological indices in the school age children of Azezo Elementary School in Gondar town.
Methods: Kato Katz technique was performed to determine infection and intensity of intestinal helminth infections. AnthroPlus software version 1.04 was used to get malnutrition indices while fully-automated haematological analyzers were used to determine haematological and biochemical parametrs.
Results: Atotal of 384 school children were recruited in this study. The overall prevalence of helminth infections was 45.8% (178/384) with the leading Ascaris lumbericoides infection (20.6%) compared to the second leading Schistosoma mansoni (17.4%) and third leading hook worm infections (13.3%). The prevalences of body mass indexes for age Z-scores (BAZ) indices were 9.6% (37) very sever thinnes, 17.2% (66) sever thinness, 38.3% (147) thinness, 34.4% (132) normal and 0.5% (2) overweight. On the other hand, the prevalences of height for age Z-scores (HAZ) indices were 12.2% (47) stunt, 87% (334) normal and 0.8% (3) over height. Of the total 384 school age children, 335 (87.2%) had normal blood glucose level (70 – 110 mg/dL) while the remaining 49 (12.8%) school age children were hypoglycemic. The number of the school children with normal total protein level (6.6 – 8 g/dL) was 259 (67.4%) while the remaining 125 (32.6%) school children were hypo-proteinaemic. The prevalence of anemia in the school age children was 33.1% (127). Intestinal helminth infections were statistically significantly associated (p = 0.000) with hypo-glycemia, hypo-proteinaemia and anemia compared with non-infected school children. The likelihood of anemia in intestinal helminth infected school children, when it was compared with uninfected was 148 times higher for both Ascaris lumbericoides-Schistosoma mansoni co-infection, 38 times for Hookworm, 20 times for Schistosoma mansoni and 3 times for Ascaris lumbericoides mono-infection.
Conclusion: Intestinal helminth infections in school age children aggravate malnutrition. Prolonged malnutrition and intestinal helminth infections could result in stunting in school-age children.
Key Words: school children; malnutrition; intestinal helminth infections; nutritional indices; Gondar town.
Short-term and long-term outcomes of robotic, laparoscopic and open radical gastrectomy in gastric cancer: A single-center retrospective study
Authors: Zhang Weifan , Zhao Xinhui , Liu Zhao , Dang Hui , Meng Lei , Xia Peng 
Published: October 2019

Abstract
Background: Few studies on the comparison among robotic, laparoscopic, and open gastrectomy had been reported in gastric cancer . The goal of this study was to evaluate the advantages of robotic-assisted gastrectomy (RAG) by comparing with laparoscopic-assisted gastrectomy(LAG) and open gastrectomy (OG). Methods: 147 gastric cancer patients who underwent gastrectomy were enrolled and retrospectively analyzed between January 2017 and July 2019. Short-term outcomes such as operation time, intraoperative estimated blood loss(EBL),number of retrieved lymph nodes, postoperative recovery, learning curve, and long-term outcome such as overall survival(OS) was compared among RAG, LAG and OG groups. Results: RAG group included 47 patients, 44 in the LAG, and 61 in the OG. Basic information such as gender, age, BMI, ASA degree were similar among three groups, and there were no statistically significances in pathological TNM staging, tumor resection extent, resection margin, methods of reconstruction( P ＞0.05). The cumulative sum(CUSUM) method showed that learning curve of RAG reached stability after 17 cases . For short-term outcomes, the RAG group had the shortest EBL( P =0.033), the shortest time to first flatus( P ＜0.001), shortest time to first intake liquid diet ( P =0.004),shortest postoperative hospital stay ( P =0.023)and the largest number of retrieved lymph nodes( P =0.044),the longest operation time( P ＜0.001), the most expensive treatment cost( P ＜0.001),however, there were no significant differences in postoperative drainage, postoperative white blood cell(WBC)count and early complications among three group( P ＞0.05). In addition to long-term outcome, similar OS was observed in three groups. Conclusion: Compared with LAG and OG, RAG has certain advantages in short-term outcomes and is a safe and reliable surgical method. But still need further prospective, multi-center research to confirm this.
Determinants of Hospital Efficiency: insights from the literature
Authors: Asbu Eyob Zere , Masri Maysoun Dimachkie 
Published: October 2019

Abstract
Background Achieving Universal Health Coverage and other health and health-related targets of the sustainable development goals entails curbing waste in health spending due to inefficiency. Inefficiency is a pervasive problem in health systems. The World Health Organization estimates that on average, 20-40% of the global total health expenditure is wasted. The proportion of total health expenditure attributed to hospitals is high, which implies that improving the efficiency of hospitals will lead to more efficient health systems. This study aims to synthetize the major determinants of hospital inefficiency and to develop a framework to identify causes of inefficiency and develop multi-factor interventions to address inefficiencies.Methods The study is based on survey of the literature on hospital efficiency and its determinants. The studies include those that employ ratio methods of efficiency analysis, data envelopment analysis and stochastic frontier models and econometric models such as the tobit regression to assess determinants of technical efficiency. Data was extracted in a table format categorized as those that are within the hospital, outside the hospital but within the health system and those that are outside the hospital and health system in the broader macroeconomic system and analyzed.Results Hospital efficiency is influenced by factors that may be internal to the hospital or external and thus could be wholly or partially out of the control of the hospital. Hospital-level characteristics that influence efficiency include ownership, size, specialization/scope economies, teaching status, membership of multihospital system and other factors such as case-mix and ratio of outpatients to inpatients. However, the effects of these variables are not definitive and consistent; all depends on the context. Factors out of the direct control of the hospital include geographic location, competition and reimbursement systems. The findings further elucidate that no single factor is effective in addressing hospital inefficiencies in isolation from others.Conclusion There is no one single magic formula or intervention that can be adopted by different hospitals and can be effective in improving hospital efficiencies. Multiple factors influence the efficiency of hospitals and to address hospital inefficiency multi-intervention packages focusing on the hospital and its environment should be developed.
Getting Around Regional Inequalities: Solidary Cooperation of the Health Professionals Relationship Network
Authors: Lama Daniela Del , Farina Milton Carlos , Oliva Eduardo de Camargo , Carvalho Antonio Aparecido de , Neto Alvaro Francisco Fernandes , Campão Andre Ciro de Lima 
Published: October 2019

Abstract
Context The Brazilian Health Care Program is formed by a complex network of public and private services that often complement each other, especially in the area of qualified Human Resources for Health (HRH). Due to social inequalities, the shortage of qualified HRH in remote regions is a reality in Brazil. The workforce imbalance associated with the socioeconomic inequality of the population in these regions reduces the access to these health maintenance services. Given this reality, this research aimed to explore and analyze the cooperation network of health professionals, a strategy used to alleviate the problems of care through social inequality, in a district of the Amazon region far from the great centers.Method A questionnaire was answered by doctors, dentists, physiotherapists and occupational therapists in the district of Rondon do Pará (Brazil). The collected data were dichotomized and analyzed using the Social Network Analysis technique using the Ucinet software.Results By means of the figures of the network of related players, it was found that cooperation between health professionals occurs in the exercise of the profession, with many strong and essential relationships for the existence of the network as well as the essential and centralized participation of medical professionals, as it reveals strong cooperative relationships with all network professionals, even if some are not reciprocal or are weak, such as relationships between physiotherapists, occupational therapists and dentists, even playing important relationship roles.Conclusions The results indicate that there is a network of health professionals cooperating in solidarity in the district of Rondon do Pará, Brazilian Amazon region. In face of difficulties in working in the profession and social inequalities, the research participants follow the principle of solidarity, cooperating with information among professional colleagues to serve the population of the district. Besides the existence of the cooperation network, being the doctors the key professionals for its execution, the collected data indicated the main difficulties faced as the lack of: opportunity for professional improvement, infrastructure to perform the work, technical support in equipment maintenance, supplies and support for people with special needs.
Examining the roles of significant others of women in the uptake of health facility delivery in Northern Uganda: perspectives from the health belief model.
Authors: Nyachwo Evelyne Baelvina , Naigino Rose , Apolot Rebecca Rachael , Wanyenze Rhoda K. , Kiguli Juliet , Bukenya Justine 
Published: October 2019

Abstract
Background: Health facility delivery improves maternal and child health outcomes but has not been fully achieved in countries with the poorest maternal health indicators. We identified and examined the roles of key influencers (significant others) of mother’s perceptions towards health facility delivery in Northern Uganda. Methods: This was an exploratory study conducted using in-depth interviews with eleven significant others in a mother’s life; who were purposively selected from four sub-counties of; Ogur, Agweng, Amach and Agali, as part of a larger study in Lira district, Northern Uganda. We also conducted seven key informant interviews with health workers involved in maternal and child health care. Data analysis using Atlas ti version.7.0 was conducted deductively following a thematic framework approach to analyse themes adapted from the health belief model. Results: The study identified husbands, biological mothers, mothers-in-law, fathers-in-law, brothers and co-wives as influencers of mother’s perceptions on uptake of health facility delivery. Other significant others included traditional birth attendants who were believed to have the ability to determine when the condition of a mother required the intervention of a medical expert. Community members such as local village leaders, village health extension workers and neighbours were also cited . Whereas husbands were regarded as ke y significant others of women, health workers emphasized that, husbands were not always available to support the mothers during pregnancy and child birth. The roles of significant others of women included: planning for birth, providing financial support, making decisions on where a mother will deliver from, continued counselling and psychosocial support. Conclusion: Programs aimed at increasing male involvement to improve maternal and child health outcomes should also target other influencers of women’s perceptions on health facility delivery including family and community members, to provide back-up support to mothers in the absence of their husbands.
Linkage disequilibrium score regression distinguishes associations between lean body mass and blood plasma proteome
Authors: Zhang Lu , Zhao Yan , Wen Yan , Ma Mei , Cheng Shiqiang , Cheng Bolun , Liu Li , Li Ping , Qi Xin , Liang Chujun , Zhang Feng 
Published: October 2019

Abstract
Background: Lean body mass (LBM) is an essential component of body composition. Recent studies observed associations between altered plasma proteins and LBM. This study aims to explore the potential genetic relationships between LBM and plasma proteome. Methods: The genome-wide association study (GWAS) summary data of LBM were driven from ~85,000 individuals of European descent. The GWAS summary data of 3,622 plasma proteins were obtained from 3,301 healthy participants. Linkage disequilibrium score regression (LDSC) analysis were conducted to evaluate the potential genetic correlation between each plasma protein and LBM using the GWAS summary statistics. Results: LDSC scan identified multiple plasma proteins for LBM, such as stabilin-1(coefficient=-0.4583, P value=0.0253) and inter-alpha-trypsin inhibitor heavy chain H1 (coefficient=-0.1716, P value=0.0314) for append LBM, and glyceraldehyde-3-phosphate dehydrogenase (coefficient=0.5997, P value=0.0315) and immunoglobulin lambda-like polypeptide 1(coefficient=0.35, P value=0.0334) for whole LBM. We also detected two common plasma proteins shared by append and whole LBM, including stabilin-1 and glyceraldehyde-3-phosphate dehydrogenase. Conclusions: This study provided an atlas of genetic correlations between LBM and plasma proteome, which are helpful for understanding the biological mechanism of LBM.
The miR-15a affected the development of sepsis and septic shock by suppression BCL-2
Authors: Wu Yunzhen , Xie Yuanli , Jiao Fangfang , Liu Xinlei 
Published: October 2019

Abstract
Background: This study aimed to investigate the mechanism of microRNA-15a (miR-15a) in the development of sepsis and septic shock. Methods: Sepsis and septic shock rat models were constructed by intraperitoneal injection of E.coli endotoxin (LPS). The real-time polymerase chain reaction (RT-PCR), Enzyme-Linked ImmunoSorbent Assay (ELISA), ematoxylin-eosin (HE) and Masson staining, TdT-mediated dUTP Nick-End Labeling (TUNEL), as well as Western blot analysis were performed to reveal the expression of microRNA-15a and changes in sepsis/septic shock myocardial cells or tissue. The rat sepsis model (sepsis group and septic shock group) was successfully established. Results: The results of HE and Mason staining showed that myocardial tissue damage gradually deepened with the progression of sepsis. Moreover, the serum levels of creatinine kinase-mb (CK-MB) and cardiac troponin I (cTnI) in model groups were significantly increased than those in control group. In addition, the RT-PCR analysis showed that miR-15a was up-regulated in model groups. Furthermore, luciferase reporter gene assay showed that 3'-UTR was the binding site of BCL-2 to miR-15a. Finally, the TUNEL and Western blot showed the cardiomyocyte apoptosis in model group. Conclusions: The overexpression of miR-15a might take part in the progression of LPS-induced sepsis and septic shock via suppressing Bcl-2 expression. Furthermore, myocardial markers such as CK-MB and cTnI might be biomarkers for sepsis progression.