bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized, Multiple-Dose, Multicenter, Comparative Parallel Study to Evaluate the Safety and Efficacy of Intravenous Infusion of Rituximab (Hetero) and Reference Medicinal Product (Rituximab, Roche) in Indian Patients of Non-Hodgkin's Lymphoma (HERILY)
Authors: Advani Suresh , Biswas Ghanashyam , Sinha Shubhadeep , Rayala Neetu Naidu , Chary Sreenivasa , Thakur Pankaj , Tripathi Santanu , Bandi Vamsi Krishna ,   Anushrita
Published: August 2018

Abstract
Objective: To compare the antitumor efficacy, safety, and pharmacodynamic (PD) characteristics of Hetero-rituximab (test) with reference medicinal product (rituximab, Roche) in non-Hodgkin's lymphoma. Patients and Methods: One hundred and thirty-five patients with diffuse large B-cell lymphoma (DLBCL) were randomized to receive intravenous infusion of either test or reference product. Efficacy (best overall response [BOR] rate [primary end point]), safety, PD (CD19), and immunological assessments (secondary end points) were done at the end of cycle 3 and cycle 6. Results:: At the end of 6 cycles, BOR rate was 73.47% in Hetero-rituximab test arm compared to the 69.09% in reference arm. Anti-rituximab antibodies were found to be negative at cycle 3 and cycle 6 for all patients. Patients treated with Hetero-rituximab show a significant depletion in CD19+ cell which was comparable with reference drug. Safety and immunogenic potential of the test drug was comparable to the reference drug in the patients of DLBCL. Conclusion: BOR rate at cycle 3, cycle 6, and end of the study lies within the prespecified limit for noninferiority which concludes that test product is therapeutically noninferior to reference medicinal product.
Incidence of Neuropathy with Weekly Paclitaxel and Role of Oral Glutamine Supplementation for Prevention of Paclitaxel Induced Peripheral Neuropathy Randomized Controlled Trial
Authors: Abbas Waseem , Rao Ranga Raju , Agarwal Amit , Saha Rajat , Bajpai Peush , Qureshi Suhail , Mittal Aditi 
Published: August 2018

Abstract
Background: Peripheral neuropathy is damage to the peripheral nerve. The most common cause of neuropathy is paclitaxel. Several avenues have been explored to ameliorate the neurotoxicity associated with paclitaxel. Clinical studies have assessed the efficacy of glutamine with different doses and schedules to prevent gastrointestinal toxicity (mucositis, diarrhea) and peripheral neuropathy in patients receiving a variety of chemotherapy agents or radiation therapy and found that glutamine can prevent paclitaxel-induced peripheral neuropathy. Methods: Total of 50 patients, aged 30 or more with diagnosis of cancer and fulfilling the inclusion and exclusion criteria, formed the study population. We assigned 25 patients to the glutamine group and 25 patients to no glutamine group. All patients received weekly paclitaxel. Results:: The incidence of neuropathy of all grades at 3 months was 78% and at 6 months was 80%.In this study, most common symptom reported was numbness in toes (74%). In this study, Grade 1 was the most common grade of symptom reported by the patient (40%–50%). 2nd, 3rd, and 4th most common grade of symptom reported by the patient was Grade 0, Grade 2, and Grade 3, respectively. There was no Grade 4 symptom reported by any patient. All the symptoms were statistically comparable in both groups (Myalgias: P = 0.066, Arthralgia: P = 0.93, Dysesthesia: P = 0.82, Paresthesia: P = 0.92, Numbness fingers: P = 0.97, Numbness toes: P = 0.60). In our study, there was no incidence of cranial nerve weakness or any incidence of the postural drop. The electrophysiological study is the best tool available and can detect neuropathy at the very earlier stage even when the clinical exam is negative. Apart from that nature of neuropathy can be determined but grading is not possible which makes very difficult to decide on follow-up examinations when the physician should intervene. Moreover, there are fluctuations in SNAP and CMAP, and these fluctuations are most probably related to the innate variability of serial nerve conduction study parameters, particularly motor and sensory amplitude. Glutamine did not prevent neurotoxicity induced by weekly paclitaxel.
Abrupt cold events in the North Atlantic Ocean in a transient Holocene simulation
Authors: Klus Andrea , Prange Matthias , Varma Vidya , Tremblay Louis Bruno , Schulz Michael 
Published: August 2018

Abstract. Abrupt cold events have been detected in numerous North Atlantic
climate records from the Holocene. Several mechanisms have been discussed as
possible triggers for these climate shifts persisting decades to centuries.
Here, we describe two abrupt cold events that occurred during an orbitally
forced transient Holocene simulation using the Community Climate System Model
version 3. Both events occurred during the late Holocene (4305–4267 BP and
3046–3018 BP for event 1 and event 2, respectively). They were characterized by substantial surface
cooling (−2.3 and −1.8 ∘C, respectively) and freshening (−0.6
and −0.5 PSU, respectively) as well as severe sea ice advance east of
Newfoundland and south of Greenland, reaching as far as the Iceland Basin in
the northeastern Atlantic at the climaxes of the cold events. Convection and
deep-water formation in the northwestern Atlantic collapsed during the
events, while the Atlantic Meridional Overturning Circulation was not
substantially affected (weakening by only about 10 % and 5 %,
respectively). The events were triggered by prolonged phases of a positive
North Atlantic Oscillation that caused substantial changes in the subpolar ocean
circulation and associated freshwater transports, resulting in a weakening of
the subpolar gyre. Our results suggest a possible mechanism by which abrupt
cold events in the North Atlantic region may be triggered by internal climate
variability without the need of an external (e.g., solar or volcanic) forcing.
Implementing northern peatlands in a global land surface model: description and evaluation in the ORCHIDEE high-latitude version model (ORC-HL-PEAT)
Authors: Largeron Chloé , Krinner Gerhard , Ciais Philippe , Brutel-Vuilmet Claire 
Published: August 2018

Abstract. Widely present in boreal regions, peatlands contain large carbon stocks
because of their hydrologic properties and high water content, which makes
primary productivity exceed decomposition rates. We have enhanced the global
land surface model ORCHIDEE by introducing a hydrological representation of
northern peatlands. These peatlands are represented as a new plant functional
type (PFT) in the model, with specific hydrological properties for peat soil.
In this paper, we focus on the representation of the hydrology of northern
peatlands and on the evaluation of the hydrological impact of this
implementation. A prescribed map based on the inventory of Yu et al. (2010)
defines peatlands as a fraction of a grid cell represented as a PFT
comparable to C3 grasses, with adaptations to reproduce shallow roots and
higher photosynthesis stress. The treatment of peatland hydrology differs
from that of other vegetation types by the fact that runoff from other soil
types is partially directed towards the peatlands (instead of directly to the
river network). The evaluation of this implementation was carried out at
different spatial and temporal scales, from site evaluation to larger scales
such as the watershed scale and the scale of all northern latitudes. The
simulated net ecosystem exchanges agree with observations from three FLUXNET
sites. Water table positions were generally close to observations, with some
exceptions in winter. Compared to other soils, the simulated peat soils have
a reduced seasonal variability in water storage. The seasonal cycle of the
simulated extent of inundated peatlands is compared to flooded area as
estimated from satellite observations. The model is able to represent more
than 89.5 % of the flooded areas located in peatland areas, where the
modelled extent of inundated peatlands reaches 0.83×106 km2.
However, the extent of peatlands in northern latitudes is too small to
substantially impact the large-scale terrestrial water storage north of
45∘ N. Therefore, the inclusion of peatlands has a weak impact on
the simulated river discharge rates in boreal regions.
Effects of land applications waste water of crude palm oil factory on some nutrient available in soil and nutrient content in palm oil
Authors: Banuwa Irwan Sukri , Pulung Mamat Anwar 
Published: August 2018

An experiment was aimed to study effect of waste water of crude palm oil (CPO) factory on some nutrient available in soil and nutrient content in palm oil. The experiment was conducted using a completely randomized block design with six levels of waste water treatments (0, 250, 500, 750, 1.000, and 1.250 L tree-1 palm oil) in three replications. The result showed that the level 750 L tree-1 of waste water treatment have significant effects on increased of nutrient available in soil (N, P, K, Ca, and Mg) including soil pH, but not significant with level 1000 and 1250 L tree-1 except P. On the other hand, nutrient content in palm oil (N, P, and K) were not significantly influenced by waste water treatments.
Perubahan Populasi Protozoa dan Alga Dominan pada Air Genangan Tanah Padi Sawah yang Diberi Bokashi Berkelanjutan
Authors: Niswati Ainin , Dermiyati . , Arif Mas Achmad Syamsul 
Published: August 2018

Protozoa and alga play important roles in biogeochemical nutrient cycles in freshwater environment, especially in the paddy fields. The changes from the conventional technologies to organic technologies will change the communities structures of organisms lived in the paddy fields environment. The fields experiment was conducted to study the population dynamic of protozoa and algae dominant inhabited in the floodwater of the paddy fields subjected by continues ‘bokashi’ application. The results showed that protozoa and algae inhabited in the paddy fields in present study were dominated by Euglena, Pleodorina, Volvox, and Diatom. The continued application of bokashi for 4 years significantly increased the total population of protozoa and algae, however, the significantly effect was obtained in the population of Volvox only. The population of protozoa and algae were affected by the time of flooding of paddy fields where it increases exponentially at the 20 and 30 days after flooding and stable after that, ecxept for Euglena where it increases little by little with time of flooding.
Identifikasi dan Kuantifikasi Metabolit Bakteri Pelarut Fosfat dan Pengaruhnya terhadap Aktivitas Rhizoctonia solani pada Tanaman Kedelai
Authors: Setiawati Tri Candra , Mihardja Paniman Asna 
Published: August 2018

Phosphate solubilizing bacteria (PSB) metabolites are organic acids, phosphomonoesterase enzyme (alkaline phosphatase) and antibiotic, which is able to dissolve insoluble phosphate. Phosphate solubilizing bacteria used in this study was expected to suppress Rhizoctonia solani attacks. This experiment was aimed at (1) identifiying and quantifying PSB metabolites, and (2) examining their capability as biocontrol agent for Rhizoctonia solani in vitro and hydroponics soybean. This study was conducted in three stages. The first stage of this study was culturing two PSB isolates (Pseudomonas putida 27.4B and Pseudomonas diminuta) in the Pikovskaya medium to analyze their metabolites. The second and third stage of this study was testing the antagonist of two bacteria to suppressed R. solani activity, which was conducted in vitro, and in hydroponics medium soybean as indicator plant. The results showed that P. putida 27.4B and P. diminuta produced organic acids i.e.: citrate, formic, succinic, acetic, propionate, butyrate, and oxalate. The totals of organic acids from each bacterium were 70,3 mg.kg-1 and 61,9 mg.kg-1. Production of alkaline phosphatase enzyme in Pikovskaya medium of P. Putida27.4B was 11,71 μg pNP .mL-1.h-1 and P. diminuta was 24,04 μg pNP.mL-1.h-1. Concentration of this enzyme in soil medium was higher than that in Pikovskaya medium with 26,27 μg pNP.g-1.h-1 and 39,03 μg pNP.g-1.h-1 respectively. This study also showed that total concentration of antibiotics (tetracycline, oxitetracycline and penicillin) produced by the PSB, were 3,2 μg.mL-1 (P. putida 27.4B) and 10,96 μg.m1-1 (P. diminuta), respectively. The results from second stage of this study showed that by using in vitro, the reduced growth of R. solani was observed 58,35% with P. putida 27.4B and 41,96% with P. diminuta. In addition, inoculations of PSB in hydroponics medium reduced the fungal pathogenesis from 10,71% to 21,42% of pre and post emergence damping-off. Visually, the symptom of pathogen attack appeared within the period of 2 untill 14 days after infection.
Repercussion of nonsteroidal anti-inflammatory drugs on the gene expression of human osteoblasts
Authors: Melguizo-Rodríguez Lucia , Costela-Ruiz Víctor J. , Manzano-Moreno Francisco J. , Illescas-Montes Rebeca , Ramos-Torrecillas Javier , García-Martínez Olga , Ruiz Concepción 
Published: August 2018

Background
Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used in clinical practice, which can have adverse effects on the osteoblast. The objective of this study was to determine the effect of NSAIDs on the osteoblast by analyzing the gene expression of different markers related to osteoblast maturation and function when treated in vitro with different NSAIDs.

Methods
Three human osteoblast lines from bone samples of three healthy volunteers were treated with 10 µM acetaminophen, indomethacin, ketoprofen, diclofenac, ibuprofen, ketorolac, naproxen, and piroxicam. The gene expression of different markers (run related transcription factor 2 [RUNX-2], type 1 collagen [COL-I], osterix [OSX], osteocalcin [OSC], bone morphogenetic protein 2 [BMP-2] and 7 [BMP-7], transforming growth factor β1 [TGF-β1], and TGFβ receptors [TGFβR1, TGFβR2; TGFBR3]) were analyzed by real-time PCR at 24 h of treatment.

Results
Expression of RUNX-2, COL-I, OSX, was reduced by treatment with all studied NSAIDs, OSC expression was reduced by all NSAIDs except for ketoprofen, naproxen, or piroxicam. Expression of BMP-7 was reduced by all NSAIDs; BMP-2 was reduced by all except for naproxen. In general, NSAID treatment increased the expression of TGF-β1, but not of its receptors (TGFβ-R1, TGFβ-R2, andTFGβ-R3), which was either unchanged or reduced by the treatment.

Conclusion
These data confirm that NSAIDs can affect osteoblast physiology, suggesting their possible impact on bone.
UBXN2A enhances CHIP‐mediated proteasomal degradation of oncoprotein mortalin‐2 in cancer cells
Authors: Sane Sanam , Hafner Andre , Srinivasan Rekha , Masood Daniall , Slunecka John l. , Noldner Collin J. , Hanson Alex D. , Kruisselbrink Taylor , Wang Xuejun , Wang Yiyang , Yin Jun , Rezvani Khosrow 
Published: August 2018

Overexpression of oncoproteins is a major cause of treatment failure using current chemotherapeutic drugs. Drug‐induced degradation of oncoproteins is feasible and can improve clinical outcomes in diverse types of cancers. Mortalin‐2 (mot‐2) is a dominant oncoprotein in several tumors, including colorectal cancer (CRC). In addition to inactivating the p53 tumor suppressor protein, mot‐2 enhances tumor cell invasion and migration. Thus, mot‐2 is considered a potential therapeutic target in several cancer types. The current study investigated the biological role of a ubiquitin‐like protein called UBXN2A in the regulation of mot‐2 turnover. An orthogonal ubiquitin transfer technology followed by immunoprecipitation, in vitro ubiquitination, and Magnetic Beads TUBE2 pull‐down experiments revealed that UBXN2A promotes carboxyl terminus of the HSP70‐interacting protein (CHIP)‐dependent ubiquitination of mot‐2. We subsequently showed that UBXN2A increases proteasomal degradation of mot‐2. A subcellular compartmentalization experiment revealed that induced UBXN2A decreases the level of mot‐2 and its chaperone partner, HSP60. Pharmacological upregulation of UBXN2A using a small molecule, veratridine (VTD), decreases the level of mot‐2 in cancer cells. Consistent with the in vitro results, UBXN2A+/− mice exhibited selective elevation of mot‐2 in colon tissues. An in vitro Anti‐K48 TUBE isolation approach showed that recombinant UBXN2A enhances proteasomal degradation of mot‐2 in mouse colon tissues. Finally, we observed enhanced association of CHIP with the UBXN2A‐mot‐2 complex in tumors in an azoxymethane/dextran sulfate sodium‐induced mouse CRC model. The existence of a multiprotein complex containing UBXN2A, CHIP, and mot‐2 suggests a synergistic tumor suppressor activity of UBXN2A and CHIP in mot‐2‐enriched tumors. This finding validates the UBXN2A‐CHIP axis as a novel and potential therapeutic target in CRC.
Bayesian Item Response Theory Estimation
Authors: Swaminathan Hariharan 
Published: August 2018

AbstractThe problem of fundamental importance in item response theory is the accurate estimation of the parameters that characterize the items and the trait levels of examinees. While, likelihood‐based approaches such as joint, conditional, and marginal maximum likelihood procedures provide reasonable estimates of the item parameters, more often than not these procedures yield estimates in the two‐ and three‐parameter models that are inadmissible in the sense that the estimates of the trait and item parameters fall outside acceptable ranges. Bayesian approaches, by taking into account prior and collateral information, overcome the problems encountered by likelihood‐based approaches.
Partially Ordered Sets: Partial Order Scalogram Analysis with Base Coordinates (POSAC)
Authors: di Bella Enrico 
Published: August 2018

AbstractPartial order scalogram analysis with base coordinates (POSAC) is a dimensionality reduction technique based on an iterative procedure that projects a set ofm‐dimensional partially ordered elements on a two‐dimensional space, while preserving “as well as possible” their partial ordering relations. POSAC is part of the theory of Partially Ordered Sets and Facet theory, and it is mainly used in evaluation studies seeking a ranking or a prioritization of statistical units using a noncompensatory approach. Being a dimensionality reduction technique, POSAC implies a loss of information that is compensated by an easier interpretation of partial ordering in two rather than inm‐dimensions. This makes POSAC especially useful to discuss policy strategies in front of nontechnical decision‐makers.
Integer‐Valued Autoregressive Moving‐Average (INARMA) Models
Authors: Weiß Christian H. 
Published: August 2018

AbstractThe INARMA models for count time series constitute an integer‐valued counterpart to the conventional autoregressive moving‐average (ARMA) models. They adapt the ARMA recursion to the count‐data case using an appropriate thinning operation, for example, binomial thinning. The basic INARMA models have stochastic properties being analogous to those of the stationary ARMA models, and also several extensions have been developed. In particular, there exist modifications of the INARMA approach to deal with bounded counts or multivariate counts.
INGARCH
and Regression Models for Count Time Series
Authors: Weiß Christian H. 
Published: August 2018

Abstract
Although the INGARCH models for count time series are said to be an integer‐valued counterpart to the generalized autoregressive conditional heteroskedasticity (GARCH) models, they may also be understood as an adaption of the autoregressive moving‐average (ARMA) models to the count‐data case. The stochastic properties of these models as well as some extensions are discussed. In particular, the INGARCH models that are a type of linear conditional regression model, and also nonlinear regression models have been proposed for count time series.
Resistance to coaching in forced‐choice testing
Authors: Orthey Robin , Vrij Aldert , Meijer Ewout , Leal Sharon , Blank Hartmut 
Published: August 2018

SummaryIn forced‐choice tests (FCTs), examinees are typically presented with questions with two equally plausible answer alternatives, of which only one is correct. The rationale underlying this test is that guilty examinees tend to avoid relevant crime information, producing a nonrandom response pattern. The validity of FCTs is reduced when examinees are informed about this underlying rationale, with coached guilty examinees refraining from avoiding the correct information but trying to provide a random mix of correct and incorrect answers. To detect such intentional randomization, a “runs” test—looking at the distribution of the number of alternations between correct and incorrect answers—has been suggested but with limited success. We designed a runs test based on distinguishing between patterns that look random and patterns that are random. Specifically, we alternated the horizontal presentation (i.e., presentation left or right on the screen) of the correct answer alternative between each trial. As a consequence, guilty examinees were faced with having to choose to randomize either between correct and incorrect answers—leading to chance performance—or between answers presented on the left or right, producing a pattern that “looks” random. As innocent examinees are unaware of the correct answers, they can only randomize between horizontal positions. Results showed that the number of correct items selected distinguished guilty from innocent examinees only when they were not informed about the underlying rationale. In contrast, alternations between correct and incorrect answers did distinguish informed guilty from innocent examinees. Incremental validity of the alternation criterion and theoretical implications are discussed.
Contraception Use Among Reproductive‐Age Women With Rheumatic Diseases
Authors: Birru Talabi Mehret , Clowse Megan E. B. , Blalock Susan J. , Moreland Larry , Siripong Nalyn , Borrero Sonya 
Published: August 2018

ObjectiveTo determine contraception use among a cohort of reproductive‐age women (ages 18–50 years) with rheumatic diseases.MethodsWe conducted a study of administrative data from a single, large medical center between the years 2013 and 2014. Women who had 1 of 21 possible rheumatic disease diagnoses and had at least 2 outpatient rheumatology visits were included in this analysis. We used logistic regression analyses to evaluate adjusted associations between the use of prescription contraception, use of potentially fetotoxic medications, and visits with rheumatologists, primary care providers, and gynecologists.ResultsOf 2,455 women in this sample, 32.1% received any prescription contraception, and 7.9% of women used highly effective prescription methods (intrauterine devices, implants, and surgical sterilization). More than 70% of women took ≥1 type of fetotoxic medication during the 2‐year study timeframe. Fetotoxic medication use was not associated with overall use of prescription contraception, but was associated with the use of highly effective contraceptive methods (adjusted odds ratio [OR] 2.26 [95% confidence interval (95% CI) 1.44–3.54]). Women who saw gynecologists or primary care providers were more likely to use prescription contraception overall (adjusted OR 3.35 [95% CI 2.77–4.05] and 1.43 [95% CI 1.18–1.73], respectively). Women who saw gynecologists were more likely to use highly versus moderately effective contraceptive methods (adjusted OR 2.35 [95% CI 1.41–3.94]). Rheumatology visits were not associated with use of prescription contraception in any models.ConclusionThis is the largest study to date to describe contraceptive use among reproductive‐age women with rheumatic diseases, and the findings reveal low use of prescription contraception. Urgent efforts are needed to improve contraceptive care and access for some women with rheumatic diseases.