bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inclusive Dualism
Authors: Nattrass Nicoli , Seekings Jeremy 
Published: July 2019

AbstractW. Arthur Lewis, the founding father of development economics, saw developing economies as dualist, that is, characterised by differences in earnings and productivity between and within economic sectors. His famous model of development, in which ‘surplus’ (unemployed and underemployed) labour was drawn out of subsistence activities and into manufacturing, was reflected in the subsequent East Asian development trajectory in which labour was drawn into low-wage, labour-intensive manufacturing, including in clothing production, before shifting into higher-wage work once the supply of surplus labour had dried up. This development strategy has become unfashionable, the concern being that in a globalized world, labour-intensive industry promises little more than an impoverishing ‘race to the bottom’. A strong strand in contemporary development discourse favours the promotion of decent work irrespective of whether surplus labour exists or not. We argue that ‘better work’ policies to ensure health and safety, minimum wages and worker representation are important. Decent work fundamentalism—that is, the promotion of higher wages and labour productivity at the cost of lower-wage job destruction—is a utopian vision with dystopic consequences for countries with high open unemployment, including most of Southern Africa. We show, using the South African clothing industry as a case study, that decent work fundamentalism ignores the benefits of dualism (the co-existence of high- and low-wage firms), resulting in the unnecessary destruction of labour-intensive jobs and the bifurcation of society into highly-paid, high-productivity insiders and unemployed outsiders. The South African case has broader relevance because of the growth in surplus labour—including in its extreme form, open unemployment—across a growing number of African countries. Inclusive dualism, as a development strategy, takes the trade-off between wages and employment seriously, prioritizes labour-intensive job creation and facilitates increased productivity where appropriate, so that jobs are created, not destroyed.
Introduction
Authors: Nattrass Nicoli , Seekings Jeremy 
Published: July 2019

AbstractIn this introduction to our book, Inclusive Dualism, we revisit W. Arthur Lewis’s famous model of development with surplus labour. Lewis emphasized the benefits of dualism, by which he meant economic differentiation and the coexistence of sectors (and of firms within sectors) characterized by different levels of productivity and wages. He proposed an expansion of relatively low-wage, labour-intensive jobs that would raise productivity by drawing ‘surplus’ labour out of subsistence activities. When such surplus labour dried up, wages would rise. In contrast to Lewis, post-2000 advocates of decent work fundamentalism promote wage increases as an instrument to increase labour productivity irrespective of labour market conditions. In the presence of surplus labour, this can have dystopic consequences, as the South African case shows. In South Africa, with its very high unemployment rates, strategies to promote relatively high-wage, high-productivity jobs came at the cost of labour-intensive development and even job destruction, thereby exacerbating poverty and inequality.
The Recordings of Andy Kirk and his Clouds of Joy
Authors: Burrows George 
Published: July 2019

Abstract
This is the first book-length study of the recordings of Andy Kirk and His Clouds of Joy. This all-black band found nationwide fame in the later 1930s and came to exemplify the Kansas City style of jazz through the records they made between 1929 and 1946. That body of work, however, serves to raise fundamental questions about the long-standing relationship between jazz music and the critical discourses about race that shaped it. This book considers how Kirk and his band appropriated musical styles in a way that was akin to the manipulation of masks in black forms of blackface performance: it signified race as much as it subverted racist conceptions of style. The band’s composer-pianist, Mary Lou Williams, and their singer Pha Terrell are reconceived within that context, and the band’s recordings are framed for their significance in understanding the way such black musicians influenced racial-musical negotiations over what and how they performed and recorded. The book brings together analytical tools from musicology with other perspectives that aim to show how intersecting discourses about race and musical styles are embedded in and expressed by the musical materials heard on the records. The difference between the band’s live and recorded performances establishes the place of audiences, especially dancing ones, in shaping jazz as a practice and conception, and it opens avenues for further investigation of the way practices of performance and recording have shaped understanding of what jazz music is and the racialized conceptions that underpin it.
The Oxford Guide to Middle High German
Authors: Jones Howard , Jones Martin H. 
Published: July 2019

Abstract
The Oxford Guide to Middle High German is the most comprehensive self-contained treatment of Middle High German available in English. It covers the language, literature, history, and culture of German in the period 1050–1350 and is designed for entry-level readers, advanced study, teaching, and reference. The book includes a large sample of texts, not only from Classical works such as Erec, the Nibelungenlied, Parzival, and Tristan, but also from mystical writing, chronicles, and legal documents; the selection represents all major dialects and the full time span of the period. Chapter 1 (‘Introduction’) defines Middle High German linguistically, geographically, and chronologically. In Chapter 2 (‘Grammar and Lexis’) each section begins with a summary of the main points; together, these form a stand-alone introductory grammar, and they are followed by detailed paragraphs for in-depth study and reference. Chapter 3 (‘Versification’) deals with metre, rhyme, lines of verse in context, and verse forms, and includes practical tips for scansion. Chapter 4 (‘Historical, Cultural, and Literary Background’) offers an account of the political and social structures of medieval Germany and a survey of the principal types of texts that originated in the period. Chapter 5 (‘Selection of Annotated Texts’) comprises over forty texts, each placed in context and provided with explanatory footnotes; the first two texts, to be taken together with the introductory grammar, are aimed at newcomers. A glossary provides full coverage of the vocabulary appearing in the texts and throughout the book.
Coarse Pricing Policies
Authors: Stevens Luminita 
Published: July 2019

AbstractThe muted volatility of inflation during the Great Recession and its aftermath has refocused attention on the constraints that firms face when adjusting prices. Using new empirical and theoretical results, I argue that each firm’s choice of how much information to acquire to set prices plays a central role in determining the patterns of pricing at the product level and the degree of aggregate price rigidity in response to shocks. In support of the information channel, I present product-level evidence that firms price goods using coarse pricing policies that are updated infrequently and consist of a small menu of prices. Firms are heterogeneous in the complexity and duration of their pricing policies, and this heterogeneity is reflected in differential responses to the Great Recession cycle, with firms exhibiting more complex policies responding more aggressively. I develop a theory of information-constrained price setting that generates coarse pricing endogenously, and quantitatively matches the discreteness, duration, and volatility of policies in the data. The information friction dampens the responsiveness of prices to shocks, and, coupled with heightened volatility, induces firms to keep prices relatively high, to protect against losses in an uncertain environment.
Sleep cardiac dysautonomia and EEG oscillations in amyotrophic lateral sclerosis
Authors: Congiu Patrizia , Mariani Sara , Milioli Giulia , Parrino Liborio , Tamburrino Ludovica , Borghero Giuseppe , Defazio Giovanni , Pereira Bruno , Fantini Maria L , Puligheddu Monica 
Published: July 2019

Abstract

Study Objectives
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease due to loss of motor neurons. However, the autonomic nervous system (ANS) can also be involved. The aim of this research was to assess the sleep macro- and microstructure, the cardiac ANS during sleep, and the relationships between sleep, autonomic features, and clinical parameters in a cohort of ALS patients.

Methods
Forty-two consecutive ALS patients underwent clinical evaluation and full-night video-polysomnography. Only 31 patients met inclusion criteria (absence of comorbidities, intake of cardioactive drugs, or recording artifacts) and were selected for assessment of sleep parameters, including cyclic alternating pattern (CAP) and heart rate variability (HRV). Subjective sleep quality and daytime vigilance were also assessed using specific questionnaires.

Results
Although sleep was subjectively perceived as satisfactory, compared with age- and sex-matched healthy controls, ALS patients showed significant sleep alteration: decreased total sleep time and sleep efficiency, increased nocturnal awakenings, inverted stage 1 (N1)/stage 3 (N3) ratio, reduced REM sleep, and decreased CAP rate, the latter supported by lower amounts of A phases with an inverted A1/A3 ratio. Moreover, a significant reduction in HRV parameters was observed during all sleep stages, indicative of impaired autonomic oscillations.

Conclusion
Our results indicate that sleep is significantly disrupted in ALS patients despite its subjective perception. Moreover, electroencephalogram activity and autonomic functions are less reactive, as shown by a decreased CAP rate and a reduction in HRV features, reflecting an unbalanced autonomic modulation.
Study of a hepatitis E virus outbreak involving drinking water and sewage contamination in Shimla, India, 2015–2016
Authors: Tripathy Anuradha S , Sharma Meenal , Deoshatwar Avinash R , Babar Prasad , Bharadwaj Rakesh , Bharti Omesh Kumar 
Published: July 2019

Abstract

Background
Hepatitis E, caused by hepatitis E virus (HEV), accounts for 50% of acute hepatitis cases in India. We report an outbreak of hepatitis E in Shimla, India, in 2015–2016.

Methods
ICMR-National Institute of Virology (NIV), Pune, received two batches of water samples from Shimla in January 2016 to test for the presence of enterically transmitted hepatitis viruses. Subsequently, 57 icterus patients were tested for various markers of hepatotropic viruses, i.e. anti-HEV IgM/IgG, anti-hepatitis A virus (anti-HAV) IgM/IgG antibodies and HEV RNA. Water samples were screened for HEV and HAV RNA followed by phylogenetic analysis.

Results
Overall, 48/57 patients availing municipal water had evidence of HEV infection, detected by serology and RT-PCR. All the water samples tested positive for HEV and HAV RNA, while the patients were negative for anti-HAV IgM antibody, indicating no recent HAV infection. Phylogenetic analysis confirmed the aetiological agent of the current outbreak to be HEV genotype 1.

Conclusions
Serology and RT-PCR confirmed HEV as the aetiology of the outbreak. The absence of new cases of hepatitis A, despite the presence of HAV in the water supply, could be due to previously acquired immunity. Sewage contamination of water leading to faecal-oral transmission of HEV still remains a concern, thus emphasising the need for a vaccination/control strategy.
Exceptional Responders in Oncology
Authors: Cummings Mackenzie , Lehrer Eric J. , Drabick Joseph J. , Gusani Niraj J. , Trifiletti Daniel M. , Zaorsky Nicholas G. 
Published: July 2019

Purpose:
We aim to systematically review and analyze the available literature on “exceptional responders” in oncology. We hypothesize that survival or patients with an exceptional response may be predicted based on clinical factors.

Materials and Methods:
A PICOS/PRISMA/MOOSE selection protocol was used to find studies that reported oncology patients with an exceptional response. A total of 333 initial articles were screened, and 76 articles were included, accounting for 85 patients. The primary outcome was survival after exceptional response therapy (ERT). The secondary outcome was survival since diagnosis. Univariate and multivariate analyses were conducted for both outcomes with 17 covariates.

Results:
The median age was 52 years (interquartile range, 35-66 y), 51.8% were male individuals, 18 (21.2%) had lung cancer, and 1 patient (1%) met all National Cancer Institute criteria for exceptional response. The most common treatment resulting in exceptional response was a form of chemotherapy (49.2%) followed by targeted therapy (26.8%) and radiation therapy (7.7%). The median time from diagnosis to initiation of ERT was 7.92 months (interquartile range, 0-24.72 mo). On multivariate analysis of survival after initiation of ERT, there were no predictors of exceptional response. On multivariate analysis of survival since diagnosis, predictors of prolonged survival included time between diagnosis and ERT initiation (hazard ratio, 0.52; 95% confidence interval, 0.32-0.87; P=0.0124) and single prior surgery versus none (0.08; 95% confidence interval, 0.01-0.98; P=0.04853).

Conclusions:
There were no clinically apparent patient or treatment factors that predicted favorable survival following ERT; instead, reporting of exceptional response appears to be biased.
Primary Cutaneous Clonal CD8+ T-Cell Lymphoproliferative Disorder Associated With Immunodeficiency due to RAG1 Mutation
Authors: Avitan-Hersh Emily , Stepensky Polina , Zaidman Irina , Nevet Mariela Judith , Hanna Suhair , Bergman Reuven 
Published: July 2019

Abstract:
The development of T-cell lymphomas, granulomatous reactions, and autoimmunity has been observed in immunodeficiency due to milder forms of recombination activating gene (RAG) deficiency. A few cases of cutaneous clonal papulonodular CD8+ lymphocytic infiltrates and cutaneous CD8+ granulomatous T-cell lymphoma have been described in association with common variable immunodeficiency, and with X-linked agammaglobulinemia. We describe a 15-year-old girl with several autoimmune disorders and recurrent infections that presented with several nodules on her cheek. Histopathological studies demonstrate histological, immunohistochemical, and molecular findings compatible with a primary cutaneous clonal CD8+ T-cell lymphoproliferative disorder. Vacuolar interface changes were also seen in the involved skin, reminiscent of cutaneous lupus erythematosus. Molecular genetic analysis revealed a germline novel homozygous missense mutation in RAG1 (T1003>C). The parents were heterozygous carriers. The facial cutaneous lesions recurred despite local radiation therapy. Because of recurrent life-threatening systemic infections, allogeneic bone marrow transplantation was performed. The pathogenesis of this primary cutaneous clonal CD8+ T-cell lymphoproliferative disorder may have been related to a chronic stimulation of autoreactive T cells in the involved skin paired with reduced RAG1 activity.
Generalized Necrobiotic Palisading Granulomatous Follicular Eruption: A Peculiar Pustular Variant of Perforating Granuloma Annulare or an Individualized Disease?
Authors: Deza Gustavo , Vidal Ainhoa , Gallardo Fernando , Iranzo Pilar , Canal de la Iglesia Laia , Pujol Ramon M. 
Published: July 2019

Abstract:
Herein, we report a case of an adult male patient with a chronic and recurrent papulopustular eruption mainly involving the trunk and lower extremities. A dense superficial perifollicular inflammatory infiltrate with palisading necrobiotic granuloma formation and infundibular perforation was observed at the histological examination, with no granulomatous inflammatory infiltrates in deeper areas. The possibility that this peculiar clinicopathological presentation constitutes a case of generalized perforating granuloma annulare (PGA) or an individualized skin condition is discussed. The observation of a pustular follicular generalized PGA represents an exceedingly rare phenomenon and constitutes an infrequent subtype of PGA that can mimic pustular eruptions secondary to many different etiologies. The clinicopathological features of this rare variant may represent a diagnostic challenge, often requiring multiple biopsies to establish a definite diagnosis.
Approach to ocular toxoplasmosis including pregnant women
Authors: Cortés Jorge A. , Roncancio Álvaro , Uribe Luis Guillermo , Cortés-Luna Carlos Fernando , Montoya José G. 
Published: July 2019

Purpose of reviewTo discuss available information on the effectiveness of anti-toxoplasma therapy for ocular toxoplasmosis and to provide clinicians with a practical approach to the disease.Recent findingsOnly eleven randomized studies were identified. In the three studies for acute retinitis, there was a clear trend in favor of treatment. In the two studies for the prevention of recurrences, trimethoprim–sulfamethoxazole prophylaxis was superior to placebo. In the six studies comparing different regimens, there was no statistically significant difference between the regimens. In the setting of acute posterior uveitis suspected to be caused by toxoplasma, serological testing should always be obtained, and anti-toxoplasma drug treatment, and corticosteroids should be instituted for at least 6 weeks. Toxoplasmic chorioretinitis during pregnancy represents a particular challenge.SummaryTreatment with at least two drugs and corticosteroids should be offered to patients with active toxoplasmic chorioretinitis. Pregnant women with confirmed acute infection and concomitant acute retinitis should be treated for the ocular lesion(s) and to prevent vertical transmission. Pregnant women with chronic Toxoplasma infection acquired prior to gestation and concomitant retinitis by reactivation should be treated for the retinitis and monitored for vertical transmission.
sEH Inhibitor Tppu Ameliorates Cecal Ligation and Puncture-Induced Sepsis by Regulating Macrophage Functions
Authors: Chen Zhihui , Tang Ying , Yu Jing , Dong Ruolan , Yang Yan , Fu Menglu , Luo Jinlan , Hu Shuiqing , Wang Dao Wen , Tu Ling , Xu Xizhen 
Published: July 2019

ABSTRACT

Background:
Sepsis is a life-threatening organ dysfunction initiated by a dysregulated response to infection, with imbalanced inflammation and immune homeostasis. Macrophages play a pivotal role in sepsis. N-[1-(1-oxopropyl)-4-piperidinyl]-N’-[4-(trifluoromethoxy)phenyl)-urea (TPPU) is an inhibitor of soluble epoxide hydrolase (sEH), which can rapidly hydrolyze epoxyeicosatrienoic acids (EETs) to the bio-inactive dihydroxyeicosatrienoic acids. TPPU was linked with the regulation of macrophages and inflammation. Here, we hypothesized that sEH inhibitor TPPU ameliorates cecal ligation and puncture (CLP)-induced sepsis by regulating macrophage functions.

Methods:
A polymicrobial sepsis model induced by CLP was used in our study. C57BL/6 mice were divided into four groups: sham+ phosphate buffer saline (PBS), sham+TPPU, CLP+PBS, CLP+TPPU. Mice were observed 48 h after surgery to assess the survival rate. For other histological examinations, mice were sacrificed 6 h after surgery. Macrophage cell line RAW264.7 was used for in vitro studies.

Results:
TPPU treatment, accompanied with increased EETs levels, markedly improved the survival of septic mice induced by CLP surgery, which was associated with alleviated organ damage and dysfunction triggered by systemic inflammatory response. Moreover, TPPU treatment significantly inhibited systemic inflammatory response via EETs-induced inactivation of mitogen-activated protein kinase signaling due to enhanced macrophage phagocytic ability and subsequently reduced bacterial proliferation and dissemination, and decreased inflammatory factors release.

Conclusion:
sEH inhibitor TPPU ameliorates cecal ligation and puncture-induced sepsis by regulating macrophage functions, including improved phagocytosis and reduced inflammatory response. Our data indicate that sEH inhibition has potential therapeutic effects on polymicrobial-induced sepsis.
An Aging-Related Single-Nucleotide Polymorphism is Associated With Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients
Authors: Lamparello Ashley J. , Namas Rami A. , Schimunek Lukas , Cohen Maria , El-Dehaibi Fayten , Yin Jinling , Barclay Derek , Zamora Ruben , Billiar Timothy R. , Vodovotz Yoram 
Published: July 2019

ABSTRACT
The contribution of individual genetic determinants of aging to the adverse clinical outcomes and altered inflammation mediator networks characteristic of aged trauma patients is unknown. The AA genotype of the aging-related single-nucleotide polymorphism (SNP) rs2075650 in TOMM40 has been associated with longevity, while the AG and GG genotypes are associated with an increased risk of Alzheimer disease. Here, we studied the effect of rs2075650 on clinical outcomes and dynamic biomarker patterns after traumatic injury. Genomic DNA was obtained from blunt trauma patients admitted to the ICU and examined for 551,839 SNPs using an Illumina microarray kit. Plasma was sampled from each patient three times within the first 24 h and daily from day 1 to 7 then assayed for 31 biomarkers using Luminex. Aged patients (65–90 years) were segregated into AA (n = 77) and AG/GG (n = 17) genotypes. Additional comparisons were made with matched groups of young patients (18–30 years), controlling for injury severity score (ISS) and sex ratio, and also segregated into AA (n = 56) and AG/GG (n = 19) genotypes. Aged patients with the AA genotype had a significantly lower requirement for ventilation and fewer days on mechanical ventilation, as well as significantly higher levels of one mediator and lower levels of two mediators. Dynamic Bayesian Network inference revealed IL-23 as a central node in each network regardless of age or genotype, with MIG and IP-10 also as key mediators in the networks of the aged patients. These findings suggest that an aging-related SNP, rs2075650, may influence clinical outcomes and inflammation networks in aged patients following blunt trauma, and thus may serve as a predictive outcome biomarker in the setting of polytrauma.
Automated sample preparation with SP3 for low-input clinical proteomics
Authors: Müller Torsten , Kalxdorf Mathias , Longuespée Rémi , Kazdal Daniel N. , Stenzinger Albrecht , Krijgsveld Jeroen 
Published: July 2019

SummaryHigh-throughput and streamlined workflows are essential in clinical proteomics for standardized processing of samples originating from a variety of sources, including fresh frozen tissue, FFPE tissue, or blood. To reach this goal, we have implemented single-pot solid-phase-enhanced sample preparation (SP3) on a liquid handling robot for automated processing (autoSP3) of tissue lysates in a 96-well format, performing unbiased protein purification and digestion, and delivering peptides that can be directly analyzed by LCMS. AutoSP3 eliminates hands-on time and minimizes the risk of error, reduces variability in protein quantification and improves longitudinal performance and reproducibility. We demonstrate the distinguishing ability of autoSP3 to process low-input samples, reproducibly quantifying 500-1000 proteins from 100-1000 cells (<100 ng protein). Furthermore, we applied this approach to a cohort of clinical FFPE pulmonary adenocarcinoma (ADC) samples, and recapitulate their separation into known histological growth patterns based on proteome profiles. Collectively, autoSP3 provides a generic, scalable, and cost-effective pipeline for routine and standardized proteomic sample processing that should enable reproducible proteomics in a broad range of clinical and non-clinical applications.