bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Novel Macromolecular Coupling Agent and its Application in Nano-Copper Lubricating Oil
Authors: Luo Juhua , Yu Ning , Cheng Mingliang , Yao Wei , Xu Jianguang 
Published: September 2019

Background:
Due to temperature-insensitive and limited tribochemical reaction,
nanolubricants have received tremendous focus over the past few years. The addition of nanoparticles
in lubricant has been demonstrated to reduce the coefficient of friction and increase the loadcarrying
capability of lubricant in coupled surfaces. Much attention has been paid to copper nanoparticles
for their perfect friction reduction and wear resistance performances. However, it is difficult to
maintain stable dispersion in lubricant oil for the aggregation of copper nanoparticles.

Methods:
A novel macromolecular coupling agent copolymer, styrene-butyl methacrylate-3-
methoxyacryloyl-propyltrimethoxyl silicon was successfully prepared by free radical polymerization.
The structure and composition of the copolymer were characterized through X-ray diffractometer,
Fourier-transform infrared spectrometer, and nuclear magnetic resonance spectrometer. The loadcarrying
capacities and anti-wear properties of the base oil were evaluated on four-ball tester.

Results:
The average size of the nano-Cu particle was around 40 nm. The modifier, St-MMA-(KH-
570) macromolecular copolymer could improve the dispersibility of nano-Cu particles. The introduction
of the nano-Cu particles helped to improve the tribological properties of base oil.

Conclusion:
The macromolecular coupling agent was synthesized by free radical solution polymerization
method. The modifier was able to bond to the nano-Cu via chemical interaction. The modified
Cu nanoparticles as the additive were able to greatly improve the anti-wear and extreme pressure
properties of base oil. The optimum concentration of modified Cu nanoparticles in base oil was 0.25
wt.%.
Development and Characterization of Solid Dispersion System for Enhancing the Solubility and Dissolution Rate of Dietary Capsaicin
Authors: Bera Sumit , Maity Subhasis , Ghosh Balaram , Ghosh Animesh , Giri Tapan K. 
Published: September 2019

Background:Capsaicin is a pungent component of chili peppers that suppresses the growth of various cancer cell lines including breast cancer. However, it shows extremely low oral bioavailability due to its poor water solubility.Objective:The objective of the present work was to improve the solubility and dissolution rate of capsaicin.Methods:Solid dispersions were prepared by the solvent evaporation method using different molar ratios of capsaicin and urea (1:1, 1:2, and 1:3). Differential Scanning Calorimetry (DSC) and X-Ray Diffraction (XRD) study were used to characterize the solid dispersion. Solid dispersions were evaluated for solubility, dissolution rate and in vitro cytotoxicity in breast cancer cell lines.Results:XRD and DSC studies exhibited the reduced crystallinity of a drug in solid dispersion. Phase solubility study shows that the drug solubility increased by increasing carrier concentration. In vitro release study of the solid dispersion showed the faster dissolution of a drug with increasing carrier concentration. Solid dispersion formulation effectively inhibited the growth of MCF-7 human breast cancer and MDA-MB-231 triple negative human breast cancer cells in an MTT assay that measures metabolic activity, but only slightly decreased cell viability when compared to capsaicin alone.Conclusion:The present study demonstrated that solid dispersion of capsaicin in PEG 6000 overcomes the problems related to the poor aqueous solubility of this drug and improving its dissolution rate.
Prolonged Adrenal Insufficiency After the Discontinuation of Mitotane Therapy
Authors: Muratori Leonardo , Pia Anna , Reimondo Giuseppe , Pisano Chiara , La Salvia Anna , Puglisi Soraya , Scagliotti Giorgio Vittorio , Sperone Paola 
Published: September 2019

Introduction::
Adrenocortical carcinoma (ACC) is a rare neoplasm characterized by a high
risk of recurrence after radical resection. The role of adjuvant systemic therapy in radically resected
patients is unclear. Mitotane, a steroidogenesis inhibitor, is the only drug approved for the systemic
treatment of advanced ACC. In 2007, a retrospective case-control study provided the evidence that
mitotane, administered for two years after successful surgery, could prolong recurrence-free survival.
Adrenal insufficiency (AI), which occurs in almost all patients during the first 12 months of treatment,
is an expected side effect of mitotane and requires steroid replacement therapy. Due to its long halflife,
mitotane-induced AI persists several months after treatment discontinuation and is managed by
cautious tapering of glucocorticoid replacement therapy.

Results::
We report a case of symptomatic AI diagnosed after a severe allergic reaction occurring three
years after the discontinuation of adjuvant mitotane therapy.

Conclusions::
The case suggests that mitotane-induced AI should be monitored for a long time to asses
full recovery of adrenal function, in order to prevent adrenal crises.
A New Method for Static Measurement of Two Axles Vehicle Centroid Height
Authors: Fan Xiaobin , Zhang Mingyue 
Published: September 2019

Background:
Vehicle centroid height is an important parameter in vehicle control systems.
It plays an important role in vehicle roll stability and handling stability. At present, there are
mainly static and dynamic measurement methods such as swing method, mass reaction method,
marking method and so on. These static measurement methods often require a fixed suspension to
make the measurement process time-consuming and laborious, and measurement errors will occur
when the suspension is not fixed firmly, and it is impossible to measure the mass center position of
spring-loaded mass and non-spring-loaded mass.

Objective:
Therefore, it is of great practical significance to study a high accuracy, low cost and fast
measurement method of vehicle centroid height. We revised and summarized all patents relating to
methods for estimating vehicle centroid height. And a new method of centroid measurement is designed
in this paper.

Methods:
According to the change of tire flattening radius and suspension, the change of spring
and non-spring mass center height when vehicle axle load changes, the method of delineation is
used to calculate the change of tire flattening radius and suspension; According to the relationship
between vehicle tilt angle and front and rear axle load, the principle of moment balance and the
principle of mass balance, it determines the geometric relationship between the variables, and to
take the moment of the contact point between the front wheel and the ground, the moment balance
equation is established, and the height of the vehicle mass center, spring load and non-spring load
mass center in the horizontal position of the vehicle are obtained.

Results:
This measurement method is different from the existing static measurement of vehicle
centroid height, it does not need the fixed suspension, only need to measure several dimensions, we
can avoid heavy labor and safety accidents brought by the fixed suspension, it can also reduce the
measurement error caused by fixation, but also can draw the centroid location of the sprung mass
and unsprung mass. The measurement method is simple, economical and accurate, and is widely
applicable on two-axle vehicles.

Conclusion:
The purpose of this paper is to provide a static and accurate measurement method of
vehicle centroid height, so as to solve the problem that the current static measurement method of
vehicle centroid height needs fixed suspension, and measurement errors will occur when the suspension
is not fixed properly, so it is impossible to measure the centroid position of spring-loaded
mass and non-spring-loaded mass.
Prioritizing the Restoration of Out of Service Transformers in a Transmission System
Authors: Gupta Madhvi , Gupta Ashwani K. , Sharma Nikhlesh K. 
Published: September 2019

Aim:
The purpose of the study is to use Fast Voltage Stability Index to find out the
weakest line of the system so that the weakest transformer of the system can be find out.

Methods:
In this paper, a technique is proposed to decide the priority selecting the out of service
transformer for repair/replacement. Based on voltage stability, priority is assigned for repairing or
replacing the particular transformer.

Results:
By using this method, a number of out of service transformers in the transmission line can
be determined and then replaced or repaired. The technique has been implemented in MATLAB
software, which is used to rank all the out of service transformer in the system. This MATLAB program
has been developed to conduct load-flow studies including Voltage Stability Index. The FVSI
proposed by Musirin et al. has been used in this work to rank the transformers which needs repair/
replacement. Transformer located at weakest line should be repaired first technically.

Conclusion:
The proposed method in this paper aims to improve the reliability and to manage the
congestion of the transmission system by repairing or replacing out of service transformer.
Analytical Modeling of D.C. Parameters of Double Gate Junctionless MOSFET in Near and Subthreshold Regime for RF Circuit Application
Authors: Sen Dipanjan , Sengupta Savio J. , Roy Swarnil , Chanda Manash , Sarkar Subir K. 
Published: September 2019

Aims::
In this work, a Junction-Less Double Gate MOSFET (JLDG MOSFET) based
CMOS inverter circuit is proposed for ultra-low power applications in the near and sub-threshold
regime operations.

Background::
D.C. performances like power, delay and voltage swing of the proposed Inverter
have been modeled analytically and analyzed in depth. JLDG MOSFET has promising features to
reduce the short-channel effects compared to the planner MOSFET because of better gate control
mechanism. So, proposed Inverter would be efficacious to offer less power dissipation and higher
speed.

Objective::
Impact of supply voltage, temperature, High-k gate oxide, TOX, TSI on the power,
delay and voltage swing of the Inverter circuits have been detailed here.

Methods:
Extensive simulations using SILVACO ATLAS have been done to validate the proposed
logic based digital circuits. Besides, the optimum supply voltage has been modelled and verified
through simulation for low voltage operations. In depth analysis of voltage swing is added to
measure the noise immunity of the proposed logic based circuits in Sub & Near-threshold operations.
For ultra-low power operation, JLDG MOSFET can be an alternative compared to conventional
planar MOSFET.

Result::
Hence, the analytical model of delay, power dissipation and voltage swing have been proposed
of the proposed logic based circuits. Besides, the ultra-low power JLDG CMOS inverter can
be an alternative in saving energy, reduction of power consumption for RFID circuit design where
the frequency range is a dominant factor.

Conclusion::
The power consumption can be lowered in case of UHF, HF etc. RF circuits using the
Double Gate Junction-less MOSFET as a device for circuit design.
Metformin Treatment Sensitizes Human Laryngeal Cancer Cell Line Hep- 2 to 5-Fluorouracil
Authors: Barlak Neslisah , Sanli Fatma , Capik Ozel , Tuysuz Elanur , Aydın Karatas Elanur , Turkez Hasan , Karatas Omer Faruk 
Published: September 2019

Background:
Larynx cancer (LCa) is the most common head and neck cancer and accounts
for 1-2.5% of all human cancers worldwide. Metformin, an oral anti-diabetic drug, has been recently
shown to have anti-cancer activity in various cancer types, and there are several studies in the literature
pointing to its potential to sensitize cancer cells to chemotherapeutic drugs.

Objective:
This study was aimed at exploring the anti-cancer effects of metformin alone or in combination
with 5-fluorouracil (5-FU) on Hep-2 cells.

Methods:
The effects of metformin and/or 5-FU on the proliferative, clonogenic, and apoptotic potential
of Hep-2 cells were evaluated with Cell Viability Detection Kit-8, soft agar assay and Annexin VFITC
Apoptosis assay, respectively. Migratory and invasive potential of cells was tested using
scratch, transwell migration and Matrigel invasion assays. Gene expression of cells exposed to metformin
and/or 5-FU was profiled using RT2 mRNA PCR Array plates.

Results:
Treatment of Hep-2 cells with metformin inhibited cell proliferation by inducing apoptosis, and
suppressed cell migration. Besides, treatment of metformin along with 5-FU improved the antiproliferative
and anti-migratory effects of 5-FU. However, unexpectedly, metformin was found to enhance
cellular invasion and reverse the inhibitory effect of 5-FU on the invasive potential of Hep-2 cells.

Conclusion:
Our findings suggest that metformin might be used as an adjuvant agent in the treatment
of LCa. However, the potential of metformin to promote the invasion of cancer cells should not be
neglected.
Performance of Natural Coagulants on Greywater Treatment
Authors: Chitra D. , Muruganandam L. 
Published: September 2019

Background:Reusing waste water by appropriate treatment is an effective method for substantiating the ever increasing water demand for construction, irrigation, domestic and industrial purposes. The greywater is the domestic waste water that does not contain the toilet effluent and it is converted and used for non-potable purpose through coagulation and flocculation by using natural coagulant.Objective:The main objective of this work is to evaluate the coagulating efficiencies of various natural coagulants on synthetic greywater by varying pH, mixing speed, mixing time and coagulant dosage.Methods:Powdered coagulants obtained from tamarind seeds, moringa oleifera, banana peels and fly ash were compared with conventional commercial coagulants like alum for synthetic and real greywater.Results:The natural coagulants have shown significant performance compared to chemicals like alum.Conclusion:The turbidity removal efficiency for tamarind seeds, moringa oleifera, banana peels and fly ash were found to be 61.33%, 85.75%, 90.42%, 94.27% against 96.49% obtained from alum on treating with synthetic grey water under identical conditions.
An Efficient Speculative Task Detection Algorithm for MapReduce Schedulers
Authors: Upadhyay Utsav , Sikka Geeta 
Published: September 2019

Background:
The MapReduce programming model was developed and designed for Google
File System to efficiently process large distributed datasets. The open source implementation of the
Google project was called Apache Hadoop. Hadoop architecture comprises of Hadoop Distributed File
System (HDFS) and Hadoop MapReduce. HDFS provides support to Hadoop for effectively managing
large datasets over the cluster and MapReduce helps in efficient large-scale distributed datasets
processing. MapReduce incorporates strategies to re-executes speculative task on some other node in
order to finish computation quickly, enhancing the overall Quality of Service (QoS). Several
mechanisms were suggested over default Hadoop’s Scheduler, such as Longest Approximate Time to
End (LATE), Self-Adaptive MapReduce scheduler (SAMR) and Enhanced Self-Adaptive MapReduce
scheduler (ESAMR), to improve speculative re-execution of tasks over the cluster.

Objective:
The aim of this research is to develop an efficient speculative task detection mechanism to
improve the overall QoS offered over Hadoop cluster.

Methods:
Our studies suggest the importance of keeping a regular track of node’s performance in order
to re-execute speculative tasks more efficiently.

Results:
We have successfully reduced the detection time of speculative tasks (~ 15%) and improved
accuracy of correct speculative task detection (~10%) as compared to existing mechanisms.

Conclusion:
This paper presents an efficient speculative task detection algorithm for MapReduce
schedulers to improve the QoS offered by Hadoop clusters.
Peningkatan Kreativitas Siswa SMP Wisata Sanur Melalui Penerapan Model Pembelajaran Group Investigation (GI) Berbasis Media Mind Mapping
Authors: Ratnani Dewa Ayu Sri 
Published: September 2019

This study aims to analyze whether the application of Group Investigation (GI) learning model Based on Mind Mapping media can improve creativities of the student of SMP Wisata Sanur. The research type is Pre-Exprimental Design with One-group Pretest-Postest Designs research design conducted at SMP Wisata Sanur from April to May. Data collection using creativity assessment rubrics with 7 aspects. The result showed that there was an increase of creativity score from 75,3 to 169,2 with significance level of each aspect of creativity, ie Design aspect (p = 0,017), Color (p = 0,017), Idea and Context (p = 0,017), Kata Key (p = 0.018), Combining ideas (p = 0.018), Hierarchy Level (p = 0.017), Presentation Concept (p = 0.017). Based on the data obtained after being tested with Wilcoxon Match Pairs there was a significant difference (p = 0,018> 0,05) on student creativity in making Mind Mapping before and after apply the learning model. The conclusion of this research is the application of cooperative learning model of Group Investigation based on Mind Mapping has an effect on to the creativity of junior high school students of Sanur Tourism.
Keywords: Group Investigation, Creativity, Mind Mapping

Abstrak. Penelitian ini bertujuan untuk menganalisis apakah penerapan model pembelajaran Group Investigation (GI) Berbasis media Mind Mapping dapat meningkatkan kreativitas siswa SMP Kerta Wisata Sanur. Jenis penelitian adalah Pre-Exprimental Design dengan rancangan penelitian One-group Pretest-Postest Designs yang dilaksanakan di SMP Wisata Sanur . Data didapatkan menggunakan rubrik penilaian kreativitas dengan 7 aspek. Hasil penelitian menunjukkan terdapat peningkatan jumlah skor kreativitas dari 75,3 menjadi 169,2 dengan taraf signifikansi masing-masing aspek kreativitas yaitu aspek Rancangan (p=0,017), Warna (p=0,017), Ide dan Konteks (p=0,017), Kata Kunci (p=0,018), Menggabungkan ide-ide (p=0,018), Tingkat Hirarki (p=0,017), Konsep Presentasi (p=0,017). Hasil uji dengan Wilcoxon Match Pairs terdapat perbedaan yang signifikan (p= 0,018 > 0,05) pada kreativitas siswa dalam membuat Mind Mapping sebelum dan sesudah menerapkan model pembelajaran kooperatif tipe Group Investigation. Kesimpulan dari penelitian ini adalah penerapan model pembelajaran kooperatif tipe Group Investigation berbasis Mind Mapping mampu meningkatkan kreativitas siswa SMP Wisata Sanur.

Kata kunci : Group Investigation, Kreativitas, Mind Mapping
Pengembangan E-modul Interaktif Berbasis Proyek Pada Mata Pelajaran Simulasi Digital Kelas X di SMK TI Bali Global Singaraja
Authors: . KOMANG REDY WINATHA , . PROF.DR. NASWAN SUHARSONO, M.Pd. , . Dr. KETUT AGUSTINI, S.Si, M.Si. 
Published: September 2019

Penelitian ini bertujuan untuk menghasilkan produk pembelajaran berupa e-modul berbasis proyek yang valid, praktis, dan efektif bagi siswa kelas X semester ganjil mata pelajaran simulasi digital. Penelitian pengembangan ini didasari oleh belum tersedianya bahan ajar inovatif yang sesuai dengan tuntutan Kurikulum 2013 pada mata pelajaran simulasi digital di SMK TI Bali Global Singaraja. Prosedur pengembangan menggunakan model ADDIE yang terdiri dari lima tahap yaitu: analysis, design, development, implementation dan evaluation.
Hasil penelitian terkait bahan ajar yang dikembangkan, telah memenuhi aspek validitas, kepraktisan, dan efektivitas. Hasil uji validitas menunjukkan bahwa e-modul berbasis proyek beserta buku panduan berada pada kategori sangat baik berdasarkan uji coba para ahli. E-modul juga telah memenuhi aspek kepraktisan dilihat dari respon guru dan siswa terkait kemudahan penggunaan dan kemenarikan desain antarmuka. Hasil uji-t menunjukkan, terdapat perbedaan yang signifikan antara nilai rata-rata hasil belajar siswa sebelum dan setelah menggunakan e-modul interaktif berbasis proyek. Di mana nilai rata-rata posttest lebih lebih besar dari nilai rata-rata pretest dan telah memenuhi kriteria ketuntasan minimal yang telah ditetapkan. Berdasarkan hal tersebut, e-modul interaktif berbasis proyek telah memenuhi aspek efektivitas.Kata Kunci : pengembangan,e-modul,simulasi digital,pembelajaran berbasis proyek This research aims to develop learning product such as valid, practical and effective interactive e-module based on project for student grade X first semester simulation digital lesson. This development research based by unavailable innovation education material which suitable with Curriculum 2013 on digital simulation subject in SMK TI Bali Global Singaraja. The development procedure use ADDIE model, it consist of five steps are analysis, design, development, implementation and evaluation.
Results of research related teaching materials developed, fulfills the validity, practicality, and effectiveness. Validity test results indicate that the interactive e-module based on project with guide books that are in the very good category based on testing experts. E-module also fulfills the practicality on the response of teachers and students related to ease of use and attractiveness of the interface design. The results of t-test showed a significant difference between the average value of student learning outcomes before and after using the interactive e-module based on project. Where the average value posttest is greater than the average pretest and have met the minimum completeness criteria that have been set. Based on this, interactive e-module based on project fulfills the effectiveness.keyword : development,e-module,digital simulation,project-based learning
Penyuluhan tentang Aktifitas Fisik dalam Peningkatan Status Kesehatan
Authors: Rosidin Udin , Sumarni Nina , Suhendar Iwan 
Published: September 2019

Melakukan aktifitas fisik merupakan salah satu indikator dalam pelaksanaan PHBS. Dalam survey awal yang dilakukan penulis menunjukkan bahwa di Desa Jayaraga sebesar 36,8 tidak melakukan aktifitas fisik. Padahal apabila dilihat dari letak geografisnya sangat dekat dengan sarana olah raga. Indikator lain ditemukan sebesar 3,8 % pertolongan persalinan tidak oleh nakes, 5,8 % balita tidak ditimbang di posyandu. Rendahnya aktifitas fisik akan berdampak pada meningkatnya prevalensi penyakit degeneratif yang akibatnya pada penurunan status kesehatan. Melakukan aktifitas fisik adalah cara untuk meningkatkan status kesehatan. Hambatan yang menyebabkan rendahnya pelaksanaan aktifitas fisik diantaranya adalah pengetahuan, motivasi dan ketersediaan sarana. Upaya yang dapat dilaksanakan untuk meningkatkan pengetahuan adalah penyuluhan. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan masyarakat tentang pentingnya aktifitas fisik bagi kesehatan. Metoda pelaksanaannya adalah melakukan penyuluhan. Melalui program ini masyarakat diberi pemahaman tentang pentingnya melaksanakan aktiifitas fisik bagi kesehatan. Jumlah peserta penyuluhan sebanyak 41 orang. Kegiatan dimulai dari tahapan perencanaan, pelaksanaan, evaluasi, hingga penyusunan laporan. Hasil kegiatan menunjukan bahwa rata rata nilai pengetahuan masyarakat sebelum dilaksanakan penyuluhan dari range 0 sampai dengan 100 sebesar 61,6. Sedangkan setelah dilaksanakan penyuluhan sebesar 69. Dari hasil tersebut dibuktikan bahwa ada peningkatan pengetahuan masyarakat tentang pentingnya aktifitas fisik setelah dilakukan penyuluhan. Kesimpulan. Pelaksanaan kegiatan ini dapat meningkatkan pengetahuan masyarakat tentang pentingnya aktifitas fisik bagi kesehatan. Rencana tidak lajut dari kegiatan ini adalah melaksanakan kerjasama dengan petugas kesehatan untuk melakukan pembinaan dan bimbingan kepada masyarakat tentang hidup sehat.Kata kunci : Aktifitas fisik, penyuluhan, PHBS.