Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial
Authors: Chaix Marie-Laure , Charreau Isabelle , Pintado Claire , Delaugerre Constance , Mahjoub Nadia , Cotte Laurent , Capitant Catherine , Raffi François , Cua Eric , Pialoux Gilles , Tremblay Cécile , Meyer Laurence , Molina Jean-Michel ,   ANRS IPERGAY Study Group, Pintado C , Loze B , Delaugerre C , Charbonneau P , Gatey C , Ponscarme D , Penot P , Niedbalski L , Veron R , Delgado J , Dalle E , Parlier S , Madelaine I , Fonsart J , Danet M , Mahjoub N , Mezreb N , Moudachirou K , Morel S , Conort G , Lorho F , Meunier M , Rozenbaum W , Molina J M , Chas J , Monfort C , Foucoin J , Boissavy B , Cousseau S , Huon S , Danet M , Djessima A , Berrebi V , Adda A , Nagat S le , Zarka L , Berdougo J , Pialoux G , Chidiac C , Mzoughi N , Clement F , Decouty A , Chapolard C , Godinot M , Adouard-groslafeige C , Koffi J , Pansu A , Becker A , Pailhes S , Bonnet F , Jeanblanc F , Brochier C , Teruin X , Rouby S , Gilly L , Cotte L , Etienne C , Tolonin F , Breaud S , Péchenot V , Bagge S , Cepitelli T , Roger PM , Rosenthal E , Cua E , Cheret A , Cornavin P , Vandamme S , Lambec J , Dumon N , Leclanche O , Huleux T , Biekre R , Robineau O , Melliez H , Bazus H , Pasquet A , Bernaud C , Besnier M , Bonnet B , Hall N , Cavellec M , Hue H , Larmet L , Colas M , Choquet R , Raffi F , Beauvais C , Arlotto P , Fortin C , Talbot A , Chamberland A , McKenzie A , Blanchette M , Rousseau R , Montheuth K , Otis J , Thompson D , Morin M , Wainberg M , Tremblay C , Meyer L , Capitant C , Charreau I , Guillon B , Netzer E , Leturque N , Binesse J , Foubert V , Saouzanet M , Euphrasie F , Carette D , Aboulker J P , Spire B , Sagaon-Teyssier L , Suzan M , Fressard L , Demoulin B , Cattin G , Lorente N , Doré V , Marchand L , Mestre S Le , Mennecier A , Choucair E , Etien N , Diallo A , Gibowski S , Simon M-C , Delfraissy J-F , Gall J M Le , Morel S , Pechenot V , Bagge S , Taba A Djessima , Danet M , Moudachirou K , Santos B Dos , Lambec J , Rouby S , Teruin X , Dumon N , Coquelin V , Brunet P , Gilly L , Cepitelli T , Porion R , Castro D Rojas , Spire B , Molina Jean-Michel , Wainberg Mark , Trottier Benoit , Tremblay Cécile , Baril Jean-Guy , Pialoux Gilles , Cotte Laurent , Chéret Antoine , Pasquet Armelle , Cua Eric , Besnier Michel , Rozenbaum Willy , Chidiac Christian , Delaugerre Constance , Bajos Nathalie , Timsit Julie , Peytavin Gilles , Fonsart Julien , Durand-Zaleski Isabelle , Meyer Laurence , Aboulker Jean-Pierre , Spire Bruno , Suzan-Monti Marie , Girard Gabriel , Castro Daniela Rojas , Préau Marie , Morin Michel , Thompson David , Capitant Catherine , Marchand Lucie , Doré Véronique , Simon Marie-Christine , Charreau Isabelle , Otis Joanne , Lert France , Diallo Alpha , Gibowski Séverine , Rabian Cecile 
Published: November 2018

Abstract
We evaluated the impact of on-demand oral tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) for pre-exposure prophylaxis (PrEP) on herpes simplex virus (HSV)-1/2 incidence among men who have sex with men (MSM) enrolled in the ANRS IPERGAY trial. Serum samples were tested at baseline and at the last visit for HSV-1/2 antibodies. Overall HSV-1 incidence was 11.7 per 100 person-years; 16.2 and 7.8 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .19). Overall HSV-2 incidence was 7.6 per 100 person-years; 8.1 and 7.0 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .75). On-demand oral PrEP with TDF/FTC failed to reduce HSV-1/2 incidence in this population.