bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Antibiotic Use Among Sepsis Patients in an Intensive Care Unit: A cross-sectional study at a referral hospital in Indonesia
Authors: Dewi Ratna S. , Radji Maksum , Andalusia Rizka 
Published: December 2018

Objectives: This study aimed to evaluate the appropriateness of antibiotic use and factors associated with outcomes among sepsis patients in an ntensive care unit (ICU). Methods: This cross-sectional study was carried out from February to May 2017 and included all adult patients with sepsis or septic shock admitted to the ICU of Dharmais Cancer Hospital, Jakarta, Indonesia. Data were collected from the patients’ medical records. Results: A total of 60 patients with sepsis or septic shock were admitted to the ICU during the study period. The most common source of infection was hospital-acquired pneumonia (61.7%) and the majority had two or more comorbidities (93.3%). There were 115 antibiotic regimens prescribed. Overall, 33.3% of patients were prescribed inappropriate types of antibiotics and 51.7% were given an inappropriate dosage. The mortality rate was 68.3%. There was a statistically significant association between patient outcome and inappropriate doses of antibiotics (P = 0.034), although not inappropriate types of antibiotics (P = 0.050). A multivariate analysis indicated that the main factors influencing patient outcome were septic shock and the presence of at least two comorbidities (P <0.050 each). Conclusion: Inappropriate doses of antibiotics, a diagnosis of septic shock and the presence of at least two comorbidities were found to significantly increase the mortality rate of sepsis patients admitted to an ICU in Indonesia.Keywords: Drug Prescription, trends; Antibiotics; Sepsis; Septic Shock; Intensive Care Units; Indonesia.
Nodular Pulmonary Amyloidosis Mimicking Metastatic Pulmonary Nodules: A case report and review of the literature
Authors: Al-Umairi Rashid S. , Al-Lawati Fatma , Al-Busaidi Fadhila M. 
Published: December 2018

Amyloidosis is a disorder characterised by the extracellular deposition of amyloid, a fibrillary protein, in various organs such as the lungs. Pulmonary nodular amyloidosis can mimic other lung conditions that present with pulmonary nodules, such as metastasis, sarcoidosis and hyalinising granuloma. We report a 60-year-old man who presented to the Royal Hospital, Muscat, Oman, in 2017 with a history of shortness of breath upon exertion, orthopnoea and bilateral lower limb swelling. A chest X-ray showed bilateral nodular opacities. Enhanced chest computed tomography revealed bilateral pulmonary nodules with a predominantly perilymphatic and subpleural distribution, giving the impression of a neoplastic nodule. A histopathological examination of biopsied lung tissue confirmed a diagnosis of nodular pulmonary amyloidosis.Keywords: Multiple Pulmonary Nodules; Amyloidosis; Computed Tomography; Case Report; Oman.
Medidas de prevenção para acidentes domésticos por envenenamento em crianças: revisão integrativa da literatura
Authors: Andrade Amanda Aparecida Ramos de , Nascimento Amanda Carvalho do , Barbosa Bianca De Paula , Rosa Gustavo José Camargos , Silva Aline Teixeira , Alves Mateus Goulart Alves 
Published: December 2018

Descrever medidas efetivas de prevenção de acidentes domésticos por envenenamento em crianças. Trata-se de uma revisão integrativa da literatura por meio da questão norteadora ‘Em crianças vítimas de acidentes domésticos por envenenamento, quais são as efetivas medidas de prevenção?’. Utilizado os bancos de dados da Literatura Latino Americana e do Caribe em Ciências da Saúde (LILACS), Literatura Internacional em Ciências da Saúde (MEDLINE) e Banco de dados em enfermagem (BDENF), realizada em abril de 2018 nos. Foram selecionados os estudos em português, disponibilidade do texto completo e artigos publicados entre 2009 a 2017, selecionados a partir dos descritores: saúde da criança, envenenamento, acidentes domésticos e prevenção de acidentes. Cinco estudos foram selecionados para uma análise aprofundada. As intoxicações são urgências clínicas e o principal objetivo da intervenção precoce é a manutenção da vida. Na infância, os acidentes domésticos por envenenamento têm sido cada vez mais responsáveis por lesões e óbitos infantis no Brasil e no mundo. É de extrema importância que o profissional de enfermagem exerça seu papel na participação de atividades direcionadas para a prevenção desse tipo de evento, adotando uma posição de educador na comunidade e, assim, atuando na promoção da saúde, na vigilância epidemiológica e na saúde coletiva. Atividades de prevenção, os casos podem ser evitados em até 90% pela combinação de fatores como educação, modificações no meio ambiente, desenvolvimento de produtos mais seguros, mais rigor no empenho da legislação existente e necessidade de criação de uma regulamentação específica.
Biodegradable Mineralized Collagen Plug for the Reconstruction of Craniotomy Burr-Holes: A Report of Three Cases
Authors: Qiu Zhiye , Zhang Yuqi , Zhang Ziqiang , Song Tianxi , Cui Fuzhai 
Published: December 2018

Objectives In this case report, we describe the design, fabrication and clinical outcomes of a novel bioresorbable, mineralized collagen burr-hole plug for the reconstruction of craniotomy burr-holes. Methods Mineralized collagen burr-hole plugs were fabricated via a biomimetic mineralization process. The biomimetic mineralized collagen has a similar chemical composition and microstructure to natural bone tissue, thereby possessing good biocompatibility and osteoconductivity. The mineralized collagen burr-hole plugs were implanted into three patients, and clinical outcomes were evaluated at one-year follow-ups. Results All bone defects healed very well using the mineralized collagen burr-hole plugs, and there were no adverse reactions at the surgical sites. Conclusions The clinical outcomes indicated that the mineralized collagen was effective for reconstructing burr-holes in the skull after craniotomy.
Rare Bilateral C3 Cervical Spondylolysis: Report of Four Cases and a Literature Review
Authors: Tong Huaiyu , Jiang Hongzhen , Yu Xinguang , Zhang Yuanzheng 
Published: December 2018

Objective To review and discuss the etiology, diagnosis and treatment C3 of bilateral cervical spondylolysis. Methods This was a retrospective review of the clinical features, imaginge findings, and treatment of 4 cases of bilateral C3 cervical spondylolysis, with a review of the literature. Results A 21-year-old woman, a 26-year-old man, a 14-year-old boy, and a 46-year-old man were diagnosed with bilateral C3 cervical spondylolysis. The patients had characteristic bilateral clefts between the articular pillar and the facets of C3, as well as spina bifida on CT. Although spondylolisthesis was not observed, spinal cord compression was definitive. All patients underwent posterior decompression with satisfactory results. Conclusions C3 cervical spondylolysis is rare condition. The cause is most likely congenital. Diagnosis is dependent on characteristic radiological features. Surgical treatment is the first choice.
Regulations and Ethical Codes for Clinical Cell Therapy Trials in Iran
Authors: Saberi Hooshang , Derakhshanrad Nazi , Arjmand Babak , Ai Jafar , Soleymani Masoud , Hamidieh Amir Ali , Joghataei Mohammad Taghi , Khan Zahid Hussain , Razavi Seyed Hassan Emami 
Published: December 2018

Objective The local regulations for conducting experimental and clinical cell therapy studies are dependent on the national and cultural approach to the issue, and may have many common aspects as well as differences with the regulations in other countries. The study reflects the latest national aspects of cell therapy in Iran and relevant regulations. Methods The following topics are discussed in the article including sources of cell harvest, regulations for cell disposal, stem cell manufacturing, and economic aspects of stem cell, based on current practice in Iran. Results All cell therapy trials in Iran are required to strictly abide with the ethical codes, national and local regulations, and safety requirements, as well as considering human rights and respect. Adherence to these standards has facilitated the conduct of human cell therapy trials for research, academic advancement, and therapy. Conclusions The cell therapy trials based on the aforementioned regulations may be assumed to be ethical and they are candidates for clinical translations based on safety and efficacy issues.
Malignant Transformation and Treatment of Cystic Mixed Germ Cell Tumor
Authors: Zhao Yapeng , Duan Hongyu , Zhang Qinghui , Shi Bingxin , Liang Hui , Zhang Yuqi 
Published: December 2018

Objective The authors report an extremely unusual presentation and management of a children pineal mixed germ cell tumor mainly composed of immature teratoma, aiming to summarize main theraptic points by literature review. Methods A cystic lesion located in the rear of third ventricle in a child was detected 3 years ago with no other therapy performed except for a ventriculo-peritoneal shunt. During the following 3 years, intermitted regular brain MRI demonstrated no evidence of lesion aggrandizement. However from 20 days before admission to our institute the patient began to present acutely with exacerbating clinical symptoms meanwhile brain MRI showed signs of abrupt revulsions of initial lesion without any incentive cause. Neurological examination revealed a significant rising of serum tumor marker level. Then surgical resection was performed immediately after admission which was followed by correlative two-course chemotherapy. Results Postoperative brain MRI demonstrated totally removing of the lesion in rear of third ventricle. Serum tumor marker level decreased remarkably after surgery and declined to normal level after two-course chemotherapy. No obvious neurological deficit occurred except for short-term memory difficulty which gradually recovered within two weeks. Soon after the second course chemotherapy the patient was currently asymptomatic and returned to school. Conclusions (1) To ensure definitive diagnosis and proper therapecutic protocols benefit from grasping clinical features of mixed germ cell tumor. (2) Overall preoperative investigation including serum tumor marker level is as critical as neurological imaging examination. (3) Surgical excision is confirmed to be the key modality of treatment. With the regarding of mixed germ cell tumor, never highlight total resection too much. (4) Postoperative adjuvant chemotherapy is recommended as further intensive treatment to improve the prognosis of mix germ cell tumor.
Repairing Skull Defects in Children with Nano-Hap/Collagen Composites: A Clinical Report of Thirteen Cases
Authors: Chen Tuoyu , Zhang Yuqi , Zuo Huancong , Zhao Yapeng , Xue Chaoqiang , Luo Bin , Zhang Qinglin , Zhu Jin , Wang Xiumei , Cui Fuzhai 
Published: December 2018

Objective To evaluate the clinical results of repairing skull defects with biomimetic bone (nano-hap/collagen composites, NHACs) in children. Methods Thirteen children with skull defects were treated with NHACs in our hospital. The NHACs molded with the help of a 3D printer were used in the operations. Results All 13 operations were successful, and patients recovered without infection. Only one patient suffered from subcutaneous hydrops post-operation. The implanted NHACs remained fixed well after 1 year, and their CT HU values raised gradually. Skull shapes of children developed normally. Recovery of neurological and cognitive function was significant. Conclusions NHAC, chosen to repair skull defects in children, can coexist with normal skull and reduce the negative effects on growth and development. NHAC could be a good choice for children with skull defects.
Post-Traumatic Cerebrospinal Fluid Rhinorrhea Associated with Craniofacial Fibrous Dysplasia: Case Report and Literature Review
Authors: Li Peng , Zhou Qiangyi , Yang Zhijun , Wang Zhenmin , Li Shiwei , Wang Xingchao , Wang Bo , Zhao Fu , Liu Pinan 
Published: December 2018

Objective Fibrous dysplasia (FD) is an unusual developmental abnormality of the skeleton. When facial and cranial bones are involved in FD, it is termed craniofacial fibrous dysplasia (CFD). Although several reports have reported that CFD has a tendency for spontaneous cerebrospinal fluid (CSF) leakage, there have been no related English-language case reports. We present the first case of post-traumatic CSF rhinorrhea associated with CFD. Methods A 30-year-old man presented with CSF rhinorrhea after a mild head trauma. Computed tomography cisternogram located a defect in the posterior wall of the right frontal sinus. Imaging examination also showed the evident expansion of multiple skull bones, spinal scoliosis, and multiple local enlargements of ribs. Without café-au-lait cutaneous spots and endocrine abnormalities, polyostotic FD was diagnosed instead of McCune-Albright syndrome (MAS). The patient underwent craniotomy fistula repair surgery. The excised bone was contoured to be thinner to increase the cranial cavity. The patient recovered well and CSF leakage did not recur. But during a nineteen-month follow up, sight in the patient's left eye was decreased. MAS was suspected. Unfortunately the patient refused to take the proposed decompression surgery and laboratory tests of serum hormones. Conclusions CFD, if the wall of the paranasal sinus is involved and the cranial cavity is decreased, may increase the risk of CSF rhinorrhea after head trauma. Expectant management is recommended in asymptomatic CFD patients even in the presence of optic nerve compression. As MAS may cause more problems, it should be precluded before polyostotic FD is diagnosed.
Complete Resection of Cavernous Malformations in the Hypothalamus: A Case Report and Review of the Literature
Authors: Wang Xingchao , Wang Zhenmin , Gao Zhixian , Liu Pinan 
Published: December 2018

Objective Cavernous malformation (CM) originating from the hypothalamus is extremely rare and the deep location presents a challenge for its neurosurgical management. We report such a case to better understand its clinical features. Methods and Results A 40-year-old male patient presented with impaired vision in the left eye. Magnetic resonance imaging (MRI) revealed a regularly shaped round lesion located in the suprasellar cistern, and a clinical diagnosis of hypothalamic CM was made. Complete microsurgical excision was performed via a right pterional craniotomy. The patient showed good recovery with no further visual acuity or field deficits postoperatively. No CM recurrence or rebleeding was seen on follow-up MRI scans performed over the course of two years. Conclusions For patients with cavernous malformation in the hypothalamus, accurate preoperative diagnosis with complete surgical removal by an appropriate surgical approach can contribute to satisfactory outcomes.
Effect of Heparin on the Expressions of Serum Intercellular Adhesion Molecule-1 and Hippocampus S100β Protein after Cardiopulmonary Resuscitation in Rabbits
Authors: Liu Wenxun , Wang Yun , Zhou Xiaohong , Cheng Wenjuan , Ye Qingshan 
Published: December 2018

Objective Use heparin during cardiac arrest (CA) in rabbits and observe the serum intercellular adhesion molecule-1 (ICAM-1) and hippocampal S100β protein expressions after cardiopulmonary resuscitation (CPR). Methods Thirty-two New Zealand rabbits were randomly divided into, Group I, control group; Group II, saline group; Group III, heparin group. Each animal underwent continuous hemodynamic monitoring including mean arterial pressure (MBP), heart rate (HR), and the end-tidal carbon dioxide partial pressure (PetCO2). Twenty-four hours after resuscitation, serum and hippocampal neurons were collected from all animals. Enzyme linked immunosorbent assay was used to detect serum ICAM-1 and immunohistochemistry to detect the S100β protein in hippocampal neurons. According to the rate of positive cells, each hippocampal specimen was categorized into four expression levels. Results The differences in the serum ICAM-1 concentration in the three groups were statistically significant. The expression of S100β protein in the hippocampus showed eight cases in group I at level 1 and none in groups II and III. There was 1 case in group II and 7 cases in group III at level 2; five cases in group II and 2 cases in group III at level 3; 2 cases in group II and 1 case in group III at level 4. The expression strength of S100β protein in the three groups differed significantly (P < 0.05). Conclusions Heparin therapy can reduce the expression of serum ICAM-1 and S100β protein in hippocampal neurons during CPR. It is possible that heparin can have a positive effect on brain protection during CPR.
Spinal Capillary Hemangioma: Report of Five Surgical Cases and Literature Review
Authors: Zhang Liang , Zhang Zhifeng , Shang Jifeng , Jia Wenqing , Yang Jun , Xu Yulun 
Published: December 2018

Objective Capillary hemangioma is a benign vascular malformation that is usually encountered in soft-tissue. Rarely, it may occur in the neuraxis, and spinal capillary hemangioma (SCH) is a rare variant of it. Existing literature on SCH is limited because of its rarity. As a result, epidemiological and clinical characteristics as well as management strategy for SCH are still lacking. Here, we present a report on five patients with pathologically proven SCH, treated in Beijing Tiantan Hospital between 2013 and 2015. Methods Patients' age, gender, clinical manifestations, radiological features, operative methods, and surgical outcomes were retrospectively reviewed, and an updated review of the literature was also provided. Results Four patients were men and one was a woman, with a median age at presentation of 43 years (range: 15–66 years). Two lesions were intramedullary, two epidural, and one intradural extramedullary. The thoracic segment was most commonly affected (n = 3, 60%), followed by the cervical (n = 1, 20%) and lumbar (n = 1, 20%) segments. Common symptoms, in descending order, were numbness and paresthesia, limb weakness, and pain. The surgical procedure was successfully performed with total resection of the tumor achieved in 4 patients and subtotal in 1 patient. During an average follow-up period of 32 months (range: 27–43 months), recovery of the clinical symptoms was observed in all five patients. Conclusions SCH is a rare benign vascular disease, for which surgical resection of the lesion, by the en bloc method, is recommended. Clinically, it usually manifests with progressive myelopathy, but early surgical intervention usually produces good results and may prevent permanent neurological deficits.
Consumo de carne bovina en el distrito de Guadalupe, San José: Un modelo econométrico para explicar el comportamiento de este. Año 2017
Authors: Brenes Granados Cristina , Chaves Moya Andrés , Flores Peralta Jorge , Monge Vargas Marilyn , Moreira Delgado Francini , Padilla Chacón Kristal 
Published: December 2018

Se determinó un modelo econométrico que pretende explicar la demanda de carne bovina para el distrito de Guadalupe; con la finalidad de brindar una propuesta econométrica que logre dar una visión acerca del comportamiento del consumidor con respecto a su consumo de carne de res, incluyendo diversos factores y una ubicación en tiempo y espacio específica.
Debido a que la demanda de carne es variable de un período a otro, se optó por utilizar datos de corte transversal, los cuales fueron generados a través encuestas (n=106), que se aplicaron en este lugar de forma aleatoria. El objetivo de la aplicación de entrevistas personales fue obtener información sobre las variables: motivaciones de consumo, frecuencia de compra, consumo según frecuencia, limitaciones de consumo, educación, ocupación, ingreso mensual y productos sustitutos.
A partir de la información obtenida de las encuestas, se corrieron diferentes modelos econométricos. Se concluyó finalmente, que el modelo econométrico que mejor se ajustaba con la demanda de carne bovina para el distrito de Guadalupe era el siguiente:
Ln Q=β1+β2lnEducación+β3lnIngreso+β4Precios+β5Gustos+β6Qt-1+β7Precio-1
El modelo presentó signos positivos y probabilidades bajas, además se logró aplicar el intercepto. Además, se logró determinar que no todas las variables consultadas en la encuesta funcionaron para estimar la demanda, tal es el caso de los sustitutos y ocupación.
Al mismo se le aplicó las pruebas de autocorrelación, multicolinealidad y heterocedasticidad, de las cuales solamente autocorrelación dio positiva.
The account of water activity in the calculation of the rate of food product shrinkage
Authors: Erlikhman V. N. , Fatykhov Yu. A. 
Published: December 2018

Refrigiration treatment and storing of the food product involves its mass loss due to its drying. The loss of mass and quality of food products is determined by ambient temperature and moisture parameters and water activity of the product itself. The use of existing formulas for calculating heat and mass exchange processes of refrigeration treatment and storage of food product is limited, because they don’t lake into account water activity and its temperature dependence on this parameter. A formula has been obtained for calculating the rate of food product shrinkage, considering the hygrothermal and thermophysical properties of the product and the environment, as well as the conditions for heat and mass transfer. The technological parameter of "water activity", with the increase of which the rate of evaporation of moisture from the product surface increases linearly, has been account in this formula. For determining dependence of food product water activity on temperature range within negative meaning it is suggested to use an analogue of tissue moisture possessing properties of diluted molecular solution. A criterion adequacy behavior of tissue moisture of food product and its analogue may be the share of frozen water. As analogue of tissue juice of food products the water solution of ethyl alcohol with mass concentration of 0.025 and temperature of freezing beginning 1(C is taken. Satisfactory results of comparing calculated and experimental data for temperature range of (1…34)(C have been obtained, which corresponds to industrial modes of buck food products refrigeration processes. Within this temperature range the water activity of water solution of ethyl alcohol drops with the temperature lowering from 0.990 to 0.748, in average amounts to water activity decrease of 0.007 to each degree of temperature drop.