bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a management support tool for stricto sensu graduate programs
Authors: Câmara Ricardo Antônio , Maccari Emerson Antonio , Ferraz Renato Ribeiro Nogueira 
Published: April 2019

Purpose
The purpose of this paper is to investigate the contribution of a project management approach to develop a tool to support the management of Brazilian stricto sensu graduate programs (SS-GP). The Adaptive approach was chosen by applying the Project Management Life Cycle (PMLC) method.

Design/methodology/approach
The study corresponds to the concept of applied research. The qualitative approach was used. The research strategy was the action research, where participants cooperate to understand their environment, identify problems and seek a solution, simultaneously producing and using the knowledge produced.

Findings
The results showed one possible way to apply a contingency project management approach to develop the tool. In addition, indicated that its application facilitated the project work, especially when finding a solution for the project’s development and when dealing with the changes inherent to the uncertainties about the problem.

Research limitations/implications
The lack of more updated information and the limitation of time and resources led to the reduction of the environment scope and of the number of functionalities developed.

Practical implications
To contribute to the generation of knowledge and expertise to support the management of SS-GP in activities such as providing information to the CAPES evaluation system, academic production analysis, collaborative researcher network analysis and post-graduation program monitoring and evaluation.

Originality/value
To fill a gap pointed out by several studies, that it is not possible to automatically generate input lists to be processed by ScriptSucupira tool, based on filtered criteria, comprising the entire universe of the Brazilian SS-PG. The creators of ScriptSucupira also declared to ignore the existence of an artifact similar to that.
AI: the HR revolution
Authors: Gulliford Fred , Parker Dixon Amy 
Published: April 2019

Purpose
Artificial intelligence (AI) and robotics are already here, influencing almost every single industry in one way or another. Organisational scientists at Qlearsite use AI and machine learning to unleash the business potential languishing in workforce data – something previously unusable because of its format. This paper aims to track the initial implementation of AI up to present day, based on Qlearsite’s corporate experience.

Design/methodology/approach
Using actual experiences, Qlearsite were tasked with demonstrating how businesses can better understand their workforce, identify performance hurdles and develop strategies to clear them, ultimately improving productivity.

Findings
While initial implementation strategies may have faced challenges by senior human resources (HR) members across industries, the multiple benefits are evident and measurable against corporate success and productivity levels today.

Originality/value
Where HR leaders and senior decision-makers struggle to solve ongoing issues, such as absenteeism, an acute problem for the financial services industry. This paper demonstrates the true value of AI, with complex issues solved by data analysis – a monumental and expensive task for any employee to carry out.
Reduction in components using modified topology for asymmetrical multilevel inverter
Authors: Mohanty Kanungo Barada , Thakre Kishor , Chatterjee Aditi , Nayak Ashwini Kumar , Kommukuri Vinaya Sagar 
Published: April 2019

PurposeThis study aims to propose a modified topology for an asymmetric multilevel inverter as a basic module that generates 13-level output voltage waveform. The basic module consists of eight switches (unidirectional and bidirectional switch) and four DC voltage sources with unequal magnitudes. The proposed topology reduces the number of switches, isolated DC sources, cost and size of the circuit significantly as compared to other topologies. In addition, the proposed circuit provides a modular structure for a multilevel inverter.Design/methodology/approachThe proposed configuration is implemented through simulation and hardware development of a single-phase 13-level inverter prototype. A multicarrier-based pulse width modulation scheme is adopted for generating switching signals by using dSPACE real-time controller.FindingsTo demonstrate the advantages of the proposed configuration, a comparative analysis is carried out with other multilevel topologies in terms of number of switches, gate driver circuits, on-state switches and blocking voltage on the switches. The comparison results confirmed that the proposed configuration requires less number of components for the same number of voltage levels. Moreover, the peak inverse voltage on switches and losses is lower in the proposed configuration.Originality/valueIn the available literature, numerous topologies are presented with main emphasis on the reduced components count. In this study, the authors proposed a new topology for an asymmetrical source configuration. The performance of the proposed topology under steady-state and dynamic conditions is evaluated using simulation and experimental implementation.
Asymmetric cyclic deformation behavior of SA 333 steel at elevated temperatures
Authors: Kumar Girendra , Kumar Ashok , Bar H.N. 
Published: April 2019

Purpose
The purpose of this paper is to study the effect of mean stress and stress amplitude on the asymmetric cyclic deformation behavior of SA333 Gr-6 C-Mn steel. Such type of loading may arise during the service period because of the load fluctuations, thermal gradients and sudden loading like seismic events. Tests were also carried out at different temperatures to understand the effect of it on sensitiveness of the materials deformation behavior.

Design/methodology/approach
Cylindrical specimen of 8-mm gauge diameter and 15-mm gauge length was fabricated from the pipe section along its axis. Stress controlled ratcheting tests were carried out by using triangular waveform for cyclic loading. The strain accumulations were measured using 12.5-mm gauge length extensometer. Ratcheting tests were carried out at fixed stress amplitude of 400 MPa and mean stress varying from 0 to 75 MPa, whereas at the fixed mean stress of 100 MPa and stress amplitude varies from 300 to 400 MPa at 300°C. To study the effect of temperature on ratcheting behavior, tests were carried out at a load of 100 MPa mean stress and 350 MPa stress amplitude, with a varying temperature between room temperature and 350°C. The stress rate of 115 MPas-1 was kept constant for all the tests.

Findings
Increase in mean stress and stress amplitude, ratcheting strain and plastic strain amplitude increases, whereas ratcheting life decreases. With an increase in temperature, ratcheting life increases and strain accumulation decreases up to 300°C, whereas on further increase in temperature, strain accumulation increases with reduction in ratcheting life. Minimum ratcheting rate was observed at 250°C and 300°C. The dynamic strain aging (DSA) phenomena lead to the hardening of the material. The investigated steel shows DSA temperature regime lies between 250°C and 300°C. The failure modes at 250°C and 300°C temperature was transgranular, whereas at 350°C complete ductile.

Research limitations/implications
The stress rate and loading condition may vary to study the ratcheting behavior.

Practical implications
From this study, the critical cyclic load may be determined. The DSA temperature regime of this material is determined at this stress rate. This could help to evaluate the cyclic deformation behavior of the material with temperature changes.

Originality/value
In this investigation, the DSA temperature regime has been determined where maximum ratcheting life, minimum strain accumulation and ratcheting rate were observed. The critical load where the minimum life of the material occurred at elevated temperature is 100 MPa mean stress and 400 MPa stress amplitude.
University Tuition Fees and High School Students’ Educational Intentions
Authors: Bahrs Michael , Siedler Thomas 
Published: April 2019

AbstractThis paper studies whether higher education tuition fees influence the intention to acquire a university degree among high school students and, if so, whether the effect on individuals from low‐income households is particularly strong. We analyse the introduction and subsequent elimination of university tuition fees in Germany across states and over time in a difference‐in‐differences setting. Using data from the Youth Questionnaire of the German Socio‐Economic Panel (SOEP), we find a large negative effect of tuition fees on the intentions of 17‐year‐olds to acquire a higher educational degree, with a decrease of around 8 percentage points (10 per cent). Individuals from low‐income households mainly drive the results. This study documents that the introduction of relatively low university tuition fees of €1,000 per academic year can considerably lower young people's educational intentions.
Physician network position and patient outcomes following implantable cardioverter defibrillator therapy
Authors: Moen Erika L. , Bynum Julie P. , Skinner Jonathan S. , O'Malley Alistair J. 
Published: April 2019

ObjectiveTo evaluate two novel measures of physician network centrality and their associations with implantable cardioverter defibrillator (ICD) procedure volume and health outcomes.Data SourcesMedicare claims and the National Cardiovascular Data Registry data from 2007 to 2011.Study DesignWe constructed a national cardiovascular disease patient‐sharing physician network and used network analysis to characterize physician network centrality with two measures: within‐hospital degree centrality (number of connections within a hospital) and across‐hospital degree centrality (number of connections across hospitals). The primary outcome was risk‐adjusted 2‐year case fatality. Hierarchical logistic regression estimated the effects of physician's within‐hospital and across‐hospital degree centrality on case fatality. We included 105 109 ICD therapy patients and 3474 ICD implanting physicians in our analyses.Principal FindingsAfter controlling for other physician and hospital characteristics, we observed greater risk‐adjusted case fatality among patients treated by physicians in the highest across‐hospital degree tertile compared to lowest tertile (OR [95% CI] = 1.10 [1.04‐1.16], P = 0.001) and lowest tertile volume physicians compared with highest volume (OR [95% CI] = 0.90 [0.84‐0.95], P < 0.001). Physician's within‐hospital degree tertile was inversely associated with case fatality but not statistically significant.ConclusionsDegree centrality measures capture information independent of procedure volume and raise questions about the quality of physicians with networks that predict worse health outcomes.
Abatacept suppresses the telomerase activity of lymphocytes in patients with rheumatoid arthritis
Authors: Otani Kazuhiro , Kurosaka Daitaro 
Published: April 2019

AbstractAimTelomere is a component of chromosomes that protects their ends from various stresses. The telomeres shorten during cell division, and their length is maintained by telomerase. The telomerase activity of lymphocytes was shown to be upregulated on lymphocyte activation, and abatacept was found to suppress the activation of T lymphocytes involved in pathogenesis of rheumatoid arthritis. Therefore, we investigated the effect of abatacept on lymphocyte telomerase activity in patients with rheumatoid arthritis.MethodThis study included 11 patients diagnosed with rheumatoid arthritis based on American College of Rheumatology 2010 criteria, who received abatacept treatment from August 2012 to August 2013. We collected their clinical data and obtained peripheral blood samples before starting abatacept, and 1, 3, 6, and 12 months after treatment. Peripheral blood mononuclear cells were extracted using Ficoll density gradient centrifugation, and T and B lymphocytes were sorted by magnetic beads. The telomerase activity of lymphocytes was determined using the telomeric repeat amplification protocol.ResultsThe telomerase activity of T lymphocytes declined from 0.357 to 0.161 (P < 0.01) at 12 months after abatacept treatment, and that of B lymphocytes declined from 0.554 to 0.202 (P < 0.01). The telomerase activity of B lymphocytes, but not that of T lymphocytes, was also significantly downregulated 1 month after treatment.ConclusionAbatacept suppressed the telomerase activity of both T and B lymphocytes, although that of B lymphocytes was downregulated before T lymphocytes. These findings imply that the clinical efficacy of abatacept during the early phase depends on the suppression of B lymphocytes.
Factors associated with patient‐physician discordance in a prospective cohort of patients with psoriatic arthritis: An Asian perspective
Authors: Wang Charmaine Tze May , Kwan Yu Heng , Fong Warren , Xiong Shu Qin , Leung Ying Ying 
Published: April 2019

AbstractObjectivesTo evaluate factors associated with patient‐physician discordance in a multiethnic Asian cohort of psoriatic arthritis (PsA) patients.MethodsWe used data from a prospective cohort of consecutive patients with PsA fulfilling the Classification Criteria for Psoriatic Arthritis, recruited from a single center in Singapore. Sociodemographic, clinical data and patient‐reported outcomes were collected using a standardized protocol at baseline, 4 months, 8 months, 1 year, 2 years and 5 years. patient‐physician discordance was defined as patient global assessment minus physician global assessment (PGA‐PhGA). We evaluated variables associated with patient‐physician discordance using generalized linear regression to control for within‐subject effect.ResultsOne hundred and fortytwo patients (51.4% male, 66.2% Chinese, mean [SD] age and duration of illness 51.1 [13.8] years and 27.5 [98.3] months) were recruited at baseline. Paired results for PGA and PhGA were available for 291 visits with median (interquartile range) follow‐up time of 11.6 (17) months. In univariable analysis, duration of illness, fatigue, pain, tender and swollen joint count, dactylitis count, and health‐related quality of life (Short Form‐36) domains were significantly correlated with patient‐physician discordance. In multivariable analysis, age, fatigue level, pain score were positively associated with patient‐physician discordance, while swollen joint count and mental health were negatively associated with patient physician discordance.ConclusionsIncreased age, higher fatigue levels, higher pain score and poorer mental health may explain underestimation of disease activity by physicians. Physicians’ overestimation of disease activity may be explained by higher swollen joint counts.
Venovenous extracorporeal membrane oxygenation treatment in a low‐volume and geographically isolated cardiothoracic centre
Authors: Ingvarsdottir Inga L. , Vidarsdottir Halla , Valsson Felix , Simonardottir Liney , Sigurdsson Martin I. , Myrdal Gunnar , Geirsson Arnar , Gudbjartsson Tomas 
Published: April 2019

BackgroundExtracorporeal membrane oxygenation (ECMO) treatment is generally offered in large tertiary cardiothoracic referral centres. Here we present the indications and outcome of venovenous‐ECMO (VV‐ECMO) treatment in a low‐volume, geographically isolated single‐centre in Iceland, a country of 350 000 inhabitants. Our hypothesis was that patient survival in such a centre can be similar to that at high‐volume centres.MethodsA retrospective study that included all patients treated with VV‐ECMO in Iceland from 1991‐2016 (n = 17). Information on demographics, indications and in‐hospital survival was collected from patient charts and APACHE II and Murray scores were calculated. Information on long‐term survival was collected from a centralized registry.ResultsSeventeen patients were treated with VV‐ECMO (nine males, median age 33 years, range 14‐74), the indication for 16 patients was severe acute respiratory distress syndrome, most often following pneumonia (n = 6), H1N1‐infection (n = 3) or drowning (n = 2). Median APACHE‐II and Murray‐scores were 20 and 3.5, respectively, and median duration of VV‐ECMO treatment was 9 days (range 2‐40 days). In total 11 patients (64,7%) survived the treatment, with 10 patients (58,8%) surviving hospital discharge, all of who were still alive at long‐term follow‐up, with a median follow‐up time of 9 years (August 15th, 2017).ConclusionVenovenous‐ECMO service can be provided in a low‐volume and geographically isolated centre, like Iceland, with short‐ and long‐term outcomes comparable to larger centres.
Hyperadrenocorticism of calorie restriction contributes to its anti‐inflammatory action in mice
Authors: Allen Brian D. , Liao Chen‐Yu , Shu Jianhua , Muglia Louis J. , Majzoub Joseph A. , Diaz Vivian , Nelson James F. 
Published: April 2019

AbstractCalorie restriction (CR), which lengthens lifespan in many species, is associated with moderate hyperadrenocorticism and attenuated inflammation. Given the anti‐inflammatory action of glucocorticoids, we tested the hypothesis that the hyperadrenocorticism of CR contributes to its attenuated inflammatory response. We used a corticotropin‐releasing‐hormone knockout (CRHKO) mouse, which is glucocorticoid insufficient. There were four controls groups: CRHKO mice and wild‐type (WT) littermates fed either ad libitum (AL) or CR (60% of AL food intake), and three experimental groups: (a) AL‐fed CRHKO mice given corticosterone (CORT) in their drinking water titrated to match the integrated 24‐hr plasma CORT levels of AL‐fed WT mice, (b) CR‐fed CRHKO mice given CORT to match the 24‐hr CORT levels of AL‐fed WT mice, and (c) CR‐fed CHRKO mice given CORT to match the 24‐hr CORT levels of CR‐fed WT mice. Inflammation was measured volumetrically as footpad edema induced by carrageenan injection. As previously observed, CR attenuated footpad edema in WT mice. This attenuation was significantly blocked in CORT‐deficient CR‐fed CRHKO mice. Replacement of CORT in CR‐fed CRHKO mice to the elevated levels observed in CR‐fed WT mice, but not to the levels observed in AL‐fed WT mice, restored the anti‐inflammatory effect of CR. These results indicate that the hyperadrenocorticism of CR contributes to the anti‐inflammatory action of CR, which may in turn contribute to its life‐extending actions.
Effect of short‐term fasting on electrocardiographic parameters
Authors: van der Stuijt Willeke , Gal Pim , Kemme Michiel J. B. , Burggraaf Jacobus 
Published: April 2019

AbstractIntroductionDuring early drug development trials, electrocardiograms (ECGs) in healthy volunteers who are in a fasting state are evaluated to screen for possible adverse cardiac effects. However, the effect of the duration of fasting on electrocardiographic parameters is largely unknown. We compared the effects of fasting on standard 12‐lead electrocardiographic recordings.MethodsElectrocardiograms were available for 432 healthy subjects (mean age 28.5 ± 12.5; 88.9% male) who participated in early drug development studies after 4‐ and 10‐hr fasting. All ECGs were automatically analyzed for conduction intervals and wave amplitudes with the Marquette 12SL algorithm and compared among fasting duration. Mixed model analyses were used to identify confounding variables.ResultsAfter 10 hr of fasting, compared to after 4 hr of fasting, mean P‐wave duration and amplitude were reduced by 1.95 ± 1.48 ms and 2.18 ± 2.75 μV, mean R wave and S wave amplitude were decreased by 25.83 ± 31.16 μV and 55.39 ± 78.72 μV, mean QRS duration was decreased by 1.84 ± 6.61 ms, and mean T‐wave duration and amplitude were decreased by 2.06 ± 0.72 ms and 9.36 ± 17.21 μV (lead II). The mean PR interval was prolonged by 4.26 ± 17.67 ms, the ventricular rate was reduced by 3.64 ± 8.61 min, and QTcF was reduced by 3.87 ± 14.50 ms. These observations persisted after correction for demographics, electrolytes, blood pressure, heart rate variability, and diurnal variation.ConclusionThe present analysis showed that 10‐hr fasting compared to 4‐hr fasting resulted in changes to the surface ECG, consisting of a reduced wave amplitude and duration and increased isoelectric interval duration.
A study on the school violence experience of children with attention‐deficit hyperactivity disorder in the context of bullying
Authors: Huh Sung‐Young , Kim Sung‐Gon , Lee Jin‐Sung , Jung Woo‐Young , Choi Bum‐Sung , Kim Ji‐Hoon 
Published: April 2019

AbstractIntroductionSchool violence causes harmful effects to victims. Harmful effects are likely to persist into adulthood. There are many studies about the relationship between attention‐deficit hyperactivity disorder (ADHD) and school violence. But, there are few comparative studies dividing groups by the context of bullying and by the school grade. Therefore, this study will identify the differences between general students and patients with ADHD under treatment, creating two groups (one with experience of the perpetration of violence and one with victimization).MethodsThis study was conducted by questionnaires that dealt with experiences of being a bully and being bulled at school in the past year as six items each. A 5‐point Likert scale was used. The ADHD group was 49, and the general students group was 245. The data were compared using the chi‐squared test. Statistical analysis was performed using SPSS version 24, with statistical significance at P < 0.05.ResultsThe ADHD group was significantly high who reported severely beating other people than the general group. Likewise, ADHD group who reported threatening other people was significantly higher than in the general group. However, for the remaining items, there was no significant difference between the ADHD group and the general student group.DiscussionPrevious studies suggested that ADHD symptoms are major causes of both bullying and being the victim of bullying. However, in this study, ADHD patients have more being the victim of bullying experiences than general students. Further, a well‐designed study will be needed to accurately evaluate the relationship between school violence and ADHD.
New therapies in development for the management of non‐infectious uveitis: A review
Authors: Hassan Muhammad , Karkhur Samendra , Bae Jeong H. , Halim Muhammad S. , Ormaechea Maria S. , Onghanseng Neil , Nguyen Nam V. , Afridi Rubbia , Sepah Yasir J. , Do Diana V. , Nguyen Quan D. 
Published: April 2019

AbstractUveitis is a spectrum of inflammatory disorders characterized by ocular inflammation and is one of the leading causes of preventable visual loss. The main aim of the treatment of uveitis is to control the inflammation, prevent recurrences of the disease and preserve vision while minimizing the adverse effects associated with the therapeutic agents. Initial management of uveitis relies heavily on the use of corticosteroids. However, monotherapy with high‐dose corticosteroids is associated with side effects and cannot be maintained long term. Therefore, steroid‐sparing agents are needed to decrease the burden of steroid therapy. Currently, the therapeutic approach for non‐infectious uveitis (NIU) consists of a step‐ladder strategy with the first‐line option being corticosteroids in various formulations followed by the use of first‐, second‐ and third‐line agents in cases with suboptimal steroid response. Unfortunately, the agents currently at our disposal have limitations such as having a narrow therapeutic window along with their own individual potential side‐effect profiles. Therefore, research has been targeted to identify newer drugs as well as new uses for older drugs that target specific pathways in the inflammatory response. Such efforts are made in order to provide targeted and safer therapy with reduced side effects and greater efficacy. Several specially designed molecular antibodies are currently in various phases of investigations that can potentially halt the inflammation in patients with NIU. In the review, we have provided a comprehensive overview of the current and upcoming therapeutic options for patients with NIU.