bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbapenem-Sparing Antibiotic Treatment Options in Children with Extended-Spectrum β-Lactamase (ESBL) Producing Bacteria
Authors: Fernandez Marisol , Quick Rachel D. , Merkel Kathryn G. , Casey Sarah , Boswell Patrick , Bailey Ann , Hauger Sarmistha B. 
Published: April 2018

Introduction:
This is a single-site retrospective chart review study that sought to assess risk factors associated with antibiotic resistance and the likelihood of susceptibility to non-carbapenem antibiotics in ESBL-producing bacteria in positive cultures in pediatric patients.

Materials and methods:
ESBL-producing bacteria were present in 222 culture-positive cases. Among 177 isolates tested, 85.9% had susceptible breakpoint to piperacillin-tazobactam. Aminoglycoside susceptibility varied with low percentages among tobramycin and gentamicin (36.9% and 50.9%, respectively), but high susceptibility for amikacin (95.5%). Most isolates (77%) were susceptible to at least one oral option, but individual susceptibilities were low. Risk factors associated with ESBL acquisition were not independently associated with antibiotic resistance to amikacin, piperacillin-tazobactam, or combined oral options, sulfamethoxazole-trimethoprim, ciprofloxacin, and amoxicillin-clavulanate.

Conclusion:
When determining empiric treatment, for an isolate identified as ESBL prior to finalized susceptibilities, piperacillin-tazobactam may be a carbapenem-sparing antibiotic option to consider based on local resistance data. Oral antibiotic options may be appropriate in non-critical patients.
ÇALIŞMAYA TUTKUNLUK DÜZEYİNİN HASTANE TÜRÜ, HASTANE LOKASYONU VE BAZI SOSYO-DEMOGRAFİK-MESLEKİ ÖZELLİKLERE GÖRE İNCELENMESİ
Authors: ŞAHİN Safiye , YOZGAT Uğur , YAKŞİ Esra 
Published: April 2018

Amaç: Çalışmanın
amacı, sağlık personelinin çalışmaya tutkunluk düzeyinin hastane türüne,
hastane lokasyonuna ve çalışanların bazı sosyo-demografik ve mesleki
özelliklere göre farklılaşıp farklılaşmadığını incelemektir.Yöntem: Araştırmanın
örneklemini İstanbul’da bulunan üç eğitim ve araştırma hastanesi, iki devlet
hastanesi, bir özel dal hastanesi ve Kırklareli’de bulunan bir devlet
hastanesinde görev yapan hekim dışındaki 659 çalışan oluşturmaktadır. Çalışmaya
tutkunluk boyutunu ölçmek amacıyla Schaufeli ve arkadaşları (2002) tarafından
geliştirilen UWES-17 ölçeği kullanılmıştır. Ölçeğin faktör yapısı Açımlayıcı
Faktör Analizi ve Doğrulayıcı Faktör Analizi ile incelenmiştir. Araştırma verilerinin
analizi SPSS 23 ve AMOS 23 programları ile yapılmıştır. Bulgular: Çalışanların sosyo-demografik
ve mesleki özellikleri ile hastane lokasyonuna göre çalışmaya tutkunluk
düzeyleri anlamlı farklıllık göstermesine karşılık; hastane türüne göre anlamlı
farklılık göstermemektedir.

Sonuç: Hasta
yoğunluğunun daha az olduğu ve trafik vb. büyükşehir problemlerinin daha az
yaşandığı küçük yerleşim yerinde bulunan bir hastanede görev yapan sağlık
personeli İstanbul’daki hastanelerde görev yapan sağlık personelinden anlamlı
olarak daha yüksek çalışmaya tutkunluk düzeyine sahiptir.
THE INFLUENCE OF ORGANIZATIONAL CULTURE AND WORK MANAGEMENT SYSTEM TO ORGANIZATIONAL COMMITMENT
Authors: Edward Edward , Rafar Rio Lesmana , Putra Adi 
Published: April 2018

The purpose of this research are: (1) To know the description of organizational culture, management system to Employees commitment at Jambi Provincial Transportation Department. (2) To know the influence of organizational culture on Organization commitment to Jambi Provincial Transportation Department. (3) work management system to Organization commitment to Jambi Provincial Transportation Department (4) To know the influence between organizational culture and management system to Organization commitment at Jambi Provincial Transportation Department. The method of analysis of this research is descriptive and quantitative. The population in the study were the employees of Jambi Provincial Transportation Department. Technique of sampling research using technique of Stratified Sampling. The total sample in this study was 123 respondents. The data were analyzed using 2 (two) ways, namely (1) Using multiple linear regression to find out the factors that influence Organization commitment with t test and F test at significance level (α = 0,05). The result of the research shows that average level of respondent's answer for organizational culture variable (X1) is 60,94 and average level of respondent answer for work management system variable (X2) is 66,41, it shows highest level. The magnitude of influence of organizational culture variable and work management system on Organization commitment at Jambi Provincial Transportation Department is 6,333 (X1) and 3,685 (X2). From the test results simultaneously can be seen that the organizational culture variables and management systems work together have a significant influence on organizational commitment. Meanwhile, it is also known that work management system variables are more dominant in influencing Employees commitment to Jambi Provincial Transportation Department.
Keywords: organizational culture, work management system, Organization commitment
Control del estrés, ira y ansiedad en pacientes con hipertensión arterial mediante TREC
Authors: Holst-Schumacher Federico , Quirós-Morales Diego 
Published: April 2018

La hipertensión Arterial constituye uno de los trastornos de mayor incidencia a nivel internacional, se recomienda el manejo de los factores psicosociales que influyen en la enfermedad. Se valoró la implementación de la Terapia Racional Emotiva Conductual (TREC) sobre los niveles de hipertensión arterial, estrés, ira y ansiedad en cuatro sujetos hipertensos de la comunidad de San Miguel de Sarapiquí. Se presentó una disminución en los niveles de tensión arterial, estrés, ira y ansiedad posterior a la aplicación de la TREC en los pacientes hipertensos.
Exploring Students’ Use of the Social Networking Site WhatsApp to foster connectedness in the online learning experience
Authors: Stone Suzanne , Logan Anna 
Published: April 2018

In recent years, increasing attention has been paid to the use of social networking tools in higher education teaching and learning. Drawing on data from a larger study focusing on student engagement in the online virtual classroom, this paper is based on research conducted with three separate cohorts of students from the Masters in Special Educational Needs (MSEN) at St. Patrick’s College now the Institute of Education, Dublin City University (DCU). Emerging from the first two phases of the research was the use of the WhatsApp social media tool by students as an informal learning space and a means of building connectedness. We explored this finding in more detail in phase three by inviting respondents to comment specifically on their use of social media throughout the programme. It emerged that the use of WhatsApp was widespread, offering students an opportunity to forge a sense of connection and the basis for developing a learning community. This paper will present findings around the use of WhatsApp with reference to literature in three areas connected to the online learning experience: Online learning as a second class learning experience, fostering connectedness within online learning contexts and social media and learning.
Efficacy of coupling gamma irradiation with calcium chloride and lemongrass oil in maintaining guava fruit quality and inhibiting fungal growth during cold storage
Authors: Hassanein Ramadan A. , Salem Ehab A. , Zahran Ahmed A. 
Published: April 2018

Abstract
This study was performed to explore the efficacy of combining more than one postharvest treatment in maintaining some quality attributes and reducing fungal pathogenicity in cold-stored guava fruits. The investigated postharvest treatments included the control, CaCl2 (4%), lemongrass oil (2 dm3 kg−1), gamma (γ) irradiation (0.2, 0.4 and 0.6 kGy), 0.4 kGy γ irradiation + CaCl2 (4%), and 0.4 kGy γ irradiation + lemongrass oil (2 dm3 kg−1). The studied physiochemical attributes included weight loss, decay percentage, fruit firmness, total soluble solids (TSS), titratable acidity (TA), and vitamin C content. Different fungal species were also isolated from decayed fruits and were identified as Alternaria alternata, Alternaria solani, Aspergillus niger, Botrytis cinerea, Fusarium solani and Rhizopus stolonifer. The severity of infection for the different fungi was determined, and an in vitro antifungal assay was conducted for lemongrass oil. All the investigated treatments generally reduced decay and water loss percentages, and controlled TSS, TA and vitamin C decrements that occurred during cold storage. On the other hand, higher irradiation doses generally increased fruit softness, and the 0.4 kGy γ dose did not contribute to the overall fruit quality when coupled with CaCl2 and lemongrass oil, compared to CaCl2 and lemongrass oil treatments alone.
Infection in central venous catheter led by parenteral nutrition of tumor patients
Authors: Wang Dan 
Published: April 2018

Abstract
With the wide application of parenteral nutrition (PN) and central venous catheter (CVC) in tumor patients, the relative infection led by CVC has become a common and troublesome hospital infection in clinics. During infusion, PN fluid forms a high-sugar and high-fat microenvironment around CVC, facilitating the adhesion, growth, and diffusion of pathogenic bacteria. This condition forms a bacterial biofilm (BF) consisting of one or several kinds of pathogenic bacteria. Upon formation of the film, pathogens in the BF can resist antibacterial drugs and immune cells, causing repeated infections of bacteria or fungi and endangering the lives of patients. In this article, we summarize the applications of PN, characteristics of CVC infection in tumor patients, mixed BF, and related research methods to provide reference for studies of mixed BF infection of CVC.
Research progress of follicular cytotoxic T cells in HIV infection
Authors: Guo Ming 
Published: April 2018

Abstract
Recently, a new type of CD8+ T-cell subset, namely, the chemokine (C-X-C motif) receptor 5 (CXCR5+) cluster of differentiation (CD8+) T-cell subset (also called the follicular cytotoxic T-cell (TFC) subgroup), has been discovered around B-cell follicles. The discovery has aroused widespread interest. However, the processes and mechanisms of TFCs taking part in the immune response of the germinal center and their specific roles must still be clearly identified. This article reviews domestic and foreign studies on factors regulating the phenotype, physiological functions, maturity, and differentiation of TFCs and roles and clinical significance of these cells in HIV infection. This review has shown good application prospects for TFCs. The author believes that further studies on TFCs can provide another tool for cytotherapy to control or cure chronic viral infections or tumors.
Research progress on the correlation between gestational vaginal microecology and vaginal infectious diseases
Authors: Dong Haiwei , Yang Xiaohui 
Published: April 2018

Abstract
The health status of the vaginal microenvironment, a complicated system, is an important indicator of female reproductive health. The vaginal flora is in a state of balance, and the microorganisms coexist and are interdependent to maintain the vaginal microecological balance, which is a kind of dynamic balance influenced by endogenous and exogenous factors. Vaginal infections are traditionally treated by killing microbes in the vagina. Given the extensive study of the internal vaginal environment, people have become gradually aware of the significance of maintaining the vaginal microecological balance rather than blindly using antimicrobial agents. The balance in the vaginal internal environment is disrupted during the gestation period as the secretion of progesterone increases. The imbalanced vaginal microecological environment may lead to vaginal infectious diseases. This article provides a review of the relationship between the vaginal microecology and infectious diseases during the gestation period.
The Oocyte’s Nucleolus Precursor Body: The Globe for Life
Authors: Benc Michal , Pendovski Lazo , Murin Matej , Strejcek Frantisek , Morovic Martin , Prochazka Radek , Laurincik Jozef 
Published: April 2018

Abstract
The nucleolus is the cell organelle responsible for ribosome synthesis and, hence, for protein synthesis. In the mammalian oocyte, the nucleolus compacts into a dense sphere with no ribosome synthesis well in advance of ovulation. It seems, that this body is of utmost importance for the development of the embryo. It is unknown, however, how it exerts this essential function. During the last two decades, great attention has been paid to the study of nucleogenesis in oocytes and early embryos, with transcription of ribosomal DNA being evaluated as one of the criteria of normal development. In this review, we summarize some aspects of nucleolus transformation during oocyte growth, as well as during early embryonic development with possible impact on the quality of the embryos used in biomedical research. This knowledge in connection with further observations will substantially contribute to the development of new criteria suitable for evaluation of oocytes and embryos used in biomedical application.
Experimental analysis of gas hold-up for gas-liquid system agitated in a vessel equipped with two impellers and vertical tubular baffles
Authors: Major-Godlewska Marta , Radecki Dawid 
Published: April 2018

Abstract
The influence of impellers system and type of liquid on the gas hold-up in the vessel has been presented in this paper. The analysis of gas hold-up was conducted on the basis of the data obtained in the vessel of the diameter D = 0.288 m, where the vessel was filled by a liquid up to the height H = 2D. The vessel was equipped in 24 vertical tubular baffles located on the circuit and two high-speed impellers situated on a shaft. Five different configurations of high-speed impellers were employed. The experiments in the gas-liquid system were conducted for setups which differed in capability of gas bubbles coalescence. The results of the experiment of the gas holdup for the five impellers configurations and four gas-liquid systems were presented in the graphic form and they were described mathematically.
Biodegradable polylactide and thermoplastic starch blends as drug release device – mass transfer study
Authors: Labus Karolina , Trusek-Holownia Anna , Semba Damian , Ostrowska Justyna , Tynski Piotr , Bogusz Jakub 
Published: April 2018

Abstract
Four different compositions of polylactide/thermoplastic starch blends (PLA/TPS blends) for application as drug carriers were examined. Initially, using cyanocobalamin (1.355 kDa) as a model compound, the blend with the highest starch content (wt. 60%) was selected for further research of mass transfer phenomenon. In this case, different concentrations of acetaminophen (0.151 kDa), doxorubicin hydrochloride (0.580 kDa) and cyanocobalamin (1.355 kDa) were used for determination of particular releasing profiles. Besides from the comparative analysis of obtained results, the values of the overall mass transfer coefficient (K) were calculated for each of tested drug molecules. Depending on the size and properties of used compound, determined values of the coefficient range from 10−11 to 10−13 m/s. Based on these outcomes, it could be stated that PLA/TPS blend selected in preliminary research, seems to be preferred material for fabrication of long-term drug delivery systems, which could be successfully applied for example in anti-cancer therapy.
Electrooxidation of phenol on carbon fibre-based anodes through continuous electrolysis of synthetic wastewater
Authors: Piotrowska Grazyna , Pierozynski Boguslaw 
Published: April 2018

Abstract
This work reports on the process of phenol electrooxidation, which is carried-out through continuous electrolysis of synthetic, sodium sulphate-based wastewater. Phenol electrodegradation is examined by means of a laboratory size (ca. 700 cm3 of working volume), poly (methyl methacrylate)-made electrolyser unit for various, carbon fibre and graphite-based anode configurations, and stainless steel cathodes, two different current-densities and concentrations of phenol in synthetically prepared wastewater solution. Proper monitoring of phenol degradation (including quantitative identification of reaction products and calculation of specific energy consumption) in wastewater is performed by means of instrumental, combined HPLC and MS technique in function of electrolysis time.
Clinical Proteomics in Kidney Disease: From Discovery to Clinical Application
Authors: Pejchinovski Martin , Mischak Harald 
Published: April 2018

Abstract
Proteome analysis has been applied in multiple studies in the context of chronic kidney disease, aiming at improving our knowledge on the molecular pathophysiology of the disease. The approach is generally based on the hypothesis that proteins are key in maintaining kidney function, and disease is a clinical consequence of a significant change of the protein level. Knowledge on critical proteins and their alteration in disease should in turn enable identification of ideal biomarkers that could guide patient management. In addition, all drugs currently employed target proteins. Hence, proteome analysis also promises to enable identifying the best suited therapeutic target, and, in combination with biomarkers, could be used as the rationale basis for personalized intervention. To assess the current status of proteome analysis in the context of CKD, we present the results of a systematic review, of up-to-date scientific research, and give an outlook on the developments that can be expected in near future. Based on the current literature, proteome analysis has already seen implementation in the management of CKD patients, and it is expected that this approach, also supported by the positive results generated to date, will see advanced high-throughput application.
Mobile Application “Neurogame” for Assessment the Attention, Focus and Concentration
Authors: Loleski Mario , Loleska Sofija , Pop-Jordanova Nada 
Published: April 2018

Abstract
Smartphones are ubiquitous, but it is still unknown what physiological functions can be monitored at clinical quality. In medicine their use is cited in many fields (cardiology, pulmology, endocrinology, rheumatology, pediatrics as well as in the field of mental health).
The aim of this paper is to explain how the use of mobile application can help clients to improve the index of their focus, concentration and motor skills. Our original developed application on Android operating system, named “neurogame” is based on an open source platform to enable assessment and therapeutic stimulation, focus and concentration with the ability to monitor the progress of the results obtained in a larger number of participants (normal subjects as well as patients with different disorders) over a period of time.
Whilst nowadays the predominant focus is on the pharmacological treatments, there is a rapidly growing interest in research on alternative options that will offer help in many cases of disorder management in terms of mobile application games.
In order to have some kind of “norms”, we evaluated a group of healthy population. Obtained results will serve as a database for comparison the future results. This article displays the results obtained as database.
Obesity in Childhood and Adolescence, Genetic Factors
Authors: Kostovski Marko , Tasic Velibor , Laban Nevena , Polenakovic Momir , Danilovski Dragan , Gucev Zoran 
Published: April 2018

Abstract
Obesity and excess weight are a pandemic phenomenon in the modern world. Childhood and adolescent obesity often ends up in obesity in adults. The costs of obesity and its consequences are staggering for any society, crippling for countries in development. Childhood obesity is also widespread in Macedonia. Metabolic syndrome, dyslipidemia and carbohydrate intolerance are found in significant numbers. Parents and grandparents are often obese. Some of the children are either dysmorphic, or slightly retarded. We have already described patients with Prader-Willi syndrome, Bardet-Biedl syndrome or WAGR syndrome. A genetic screening for mutations in monogenic obesity in children with early, rapid-onset or severe obesity, severe hyperphagia, hypogonadism, intestinal dysfunction, hypopigmentation of hair and skin, postprandial hypoglycaemia, diabetes insipidus, abnormal leptin level and coexistence of lean and obese siblings in the family discovers many genetic forms of obesity. There are about 30 monogenic forms of obesity. In addition, obesity is different in ethnic groups, and the types of monogenic obesity differ. In brief, an increasing number of genes and genetic mechanisms in children continue to be discovered. This sheds new light on the molecular mechanisms of obesity and potentially gives a target for new forms of treatment.
Moleculary Confirmed, Cytogenetic Remission in a Case with Myelodysplastic Syndrome Treated with Azacitidne
Authors: Panovska-Stavridis Irina , Ivanovski Martin , Trajkova Sanja , Pivkova-Veljanovska Aleksandra , Popova-Labaceska Marija , Matevska-Geshovska Nadica , Noveski Predrag , Plaseska-Karanfilska Dijana , Cevreska Lidija , Dimovski Aleksandar J. 
Published: April 2018

Abstract
Myelodysplastic syndrome (MDS) is a diverse group of clonal hematologic neoplasms. The only curative treatment for MDS is allogeneic stem cell transplantation (SCT). Epigenetic changes play an important role in the pathogenesis of MDS and treatment with DNA methyl transferase inhibitors, Azacitidine, significantly prolong the survival of high-risk MDS patients. Here we report a case of a 58-year-old male presented with pancytopenia, macrocytosis, and hyperplastic bone marrow with 3-lineage dysplasia with ~14% of myeloid blasts. Cytogenetic studies with G banding showed normal karyotype. Multiplex ligation-dependent probe amplification (MLPA) screening for most predictive cytogenetic abnormalities of MDS showed loss of the Y chromosome. Those findings later were confirmed with Quantitative Fluorescent (QF)-PCR and specific MLPA for Y chromosome, showing loss of the Y chromosome in >80% of cells. He was diagnosed with MDS-RAEB2 according to 2008 WHO classification and stratified into high risk group (IPSS score 5). Unrelated allogeneic SCT was planed and bridging treatment with Azacitidine at a dose of 75mg/m2/daily subcutaneously for 7 days every 28 days was initiated. Hematologic improvements, according to the International Working Group 2006 criteria, were observed after 4 cycles of Azacitidine treatment. After 6 cycles, complete hematological remission was achieved. Interestingly, molecular analysis performed after the 8th cycle showed normal presence of Y chromosome indicating a cytogenetic remission, molecularly confirmed. Maintenance treatment with Azacitidine was assigned, and the scheduled SCT was postponed. Experience from our case showed that the loss of the Y chromosome was related to the disease onset, and indicated that Azacitidine might be consider as effective treatment for MDS cases associated with good cytogenetic
The Dematel Method in the Analysis of the Residential Real Estate Market in Bialystok
Authors: Gołąbeska Elżbieta 
Published: April 2018

Abstract1
The article is of a dual character. On the one hand, it concerns the analysis of the real estate market in terms of investment attractiveness and the influence of particular attributes of property on attractiveness itself. On the other hand, it proposes the use as a research tool selected using one of the multicriteria methods (DEMATEL), which is an alternative to commonly used statistical methods. The theoretical part of the work is completed by a brief computational example which deals with the analysis of factors affecting the prices of residential real estate on a local scale.