bluuebunny/crossref_metadata_2025_split huggingface dataset:
I3−‐Mediated Oxygen Evolution Activities to Boost Rechargeable Zinc‐Air Battery Performance with Low Charging Voltage and Long Cycling Life
Authors: Zou Xiaohong , Lu Qian , Wu Lizhen , Zhang Kouer , Tang Mingcong , Xie Haijiao , Zhang Xiao , Shao Zongping , An Liang 
Published: November 2024

AbstractAn effective strategy to facilitate oxygen redox chemistry in metal‐air batteries is to introduce a redox mediator into the liquid electrolyte. The rational utilization of redox mediators to accelerate the charging kinetics while ensuring the long lifetime of alkaline Zn‐air batteries is challenging. Here, we apply commercial acetylene black catalysts to achieve an I3−‐mediated Zn‐air battery by using ZnI2 additives that provide I3− to accelerate the cathodic redox chemistry and regulate the uniform deposition of Zn2+ on the anode. The Zn‐air battery performs an ultra‐long cycle life of over 600 h at 5 mA cm−2 with a final charge voltage of 1.87 V. We demonstrate that I− mainly generates I3− on the surface of carbon catalysts during the electrochemically charging process, which can further chemically react with OH− to generate oxygen and further revert to I−, thus obtaining a stable electrochemical system. This work offers a strategy to simultaneously improve the cycling life and reduce the charging voltage of Zn‐air batteries through redox mediator methods.
Simultaneous Suppression of Multilayer Ion Migration via Molecular Complexation Strategy toward High‐Performance Regular Perovskite Solar Cells
Authors: Zhou Qian , Yang Yingying , He Dongmei , Yang Ke , Yu Yue , Liu Xinxing , Zhang Jiajia , Shai Xuxia , Wang Jinsong , Yi Jianhong , Li Meicheng , Chen Jiangzhao 
Published: November 2024

AbstractThe migration and diffusion of Li+, I− and Ag impedes the realization of long‐term operationally stable perovskite solar cells (PSCs). Herein, we report a multifunctional and universal molecular complexation strategy to simultaneously stabilize hole transport layer (HTL), perovskite layer and Ag electrode by the suppression of Li+, I− and Ag migration via directly incorporating bis(2,4,6‐trichlorophenyl) oxalate (TCPO) into HTL. Meanwhile, TCPO co‐doping results in enhanced hole mobility of HTL, advantageous energy band alignment and mitigated interfacial defects, thereby leading to facilitated hole extraction and minimized nonradiative recombination losses. TCPO‐doped regular device achieves a peak power conversion efficiency (PCE) of 25.68 % (certified 25.59 %). The unencapsulated TCPO doped devices maintain over 90 % of their initial efficiencies after 730 h of continuous operation under one sun illumination, 2800 h of storage at 30 % relative humidity, and 1200 h of exposure to 65 °C, which represents one of the best stabilities reported for regular PSCs. This work provides a new approach to enhance the PCE and long‐term stability of PSCs by host–guest complexation strategy via rational design of multifunctional ligand molecules.
UV ozone‐modified Fe3O4‐PDMS film for solvent‐driven soft actuators with controlled and multi‐stable deformations
Authors: Xu Haoran , Li Congwei , Lei Ming , Kang Xin , Zeng Shaofeng , Lin Junjie , Yang Kaihuai , Weng Mingcen , Guo Qiaohang 
Published: November 2024

AbstractIn recent years, solvent‐driven actuators have been capable of controlling deformations in response to external stimuli. However, a magnetic polydimethylsiloxane (PDMS) composite film with magnetic properties is traditionally developed using the micro‐electro‐mechanical system process. Although it has general actuation deformation, the composite film suffers from the problems of actuation and control. Here, this is done by co‐mixing PDMS and ferrosoferric oxide (Fe3O4) then waiting for curing and then undergoing ultraviolet‐ozone (UVO) surface treatment. By adjusting the time and orientation of the UVO treatment, a series of solvent‐driven actuators with multiform steady‐state structures (e.g., mono/bistable helix) is proposed. In addition, the deformation of the composite film under different geometrical parameters and surface constraints was visually predicted by incorporating finite element analysis methods. In addition, the controlled deformations of the composite film (such as box‐like, folded, and so on) are carried out by self‐morphing design. Finally, four bionic applications are also proposed to demonstrate the practical use of soft actuators based on Fe3O4‐PDMS films in bionic robots. This work provides new strategies for designing and fabricating programmable and controllable soft actuators and lays the foundation for a wide range of smart material applications.
FoxO1 Deficiency in Monocytic Myeloid‐Derived Suppressor Cells Exacerbates B Cell Dysfunction in Systemic Lupus Erythematosus
Authors: Tan Liping , Kong Wei , Zhou Kangxing , Wang Shuangan , Liang Jun , Hou Yayi , Dou Huan 
Published: November 2024

ObjectiveMyeloid‐derived suppressor cells (MDSCs) contribute to the pathogenesis of systemic lupus erythematosus (SLE), in part due to promoting the survival of plasma cells. FoxO1 expression in monocytic MDSCs (M‐MDSCs) exhibits a negative correlation with the SLE Disease Activity Index score. This study aimed to investigate the hypothesis that M‐MDSC–specific FoxO1 deficiency enhances aberrant B cell function in aggressive SLE.MethodsWe used GEO data sets and clinical cohorts to verify the clinical significance of FoxO1 expression and circulating M‐MDSCs. Using Cre‐LoxP technology, we generated myeloid FoxO1 deficiency mice (mFoxO1−/−) to establish murine lupus–prone models. The transcriptional stage was assessed by integrating chromatin immunoprecipitation (ChIP)–sequencing with transcriptomic analysis, luciferase reporter assay, and ChIP–quantitative polymerase chain reaction. Methylated RNA immunoprecipitation sequencing, RNA sequencing, and CRISPR‐dCas9 were used to identify N6‐adenosine methylation (m6A) modification. In vitro B cell coculture experiments, capmatinib intragastric administration, m6A‐modulated MDSCs adoptive transfer, and sample validation of patients with SLE were performed to determine the role of FoxO1 on M‐MDSCs dysregulation during B cell autoreacted with SLE.ResultsWe present evidence that low FoxO1 is predominantly expressed in M‐MDSCs in both patients with SLE and lupus mice, and mice with myeloid FoxO1 deficiency (mFoxO1−/−) are more prone to B cell dysfunction. Mechanically, FoxO1 inhibits mesenchymal‐epithelial transition factor protein (Met) transcription by binding to the promoter region. M‐MDSCs FoxO1 deficiency blocks the Met/cyclooxygenase2/prostaglandin E2 secretion pathway, promoting B cell proliferation and hyperactivation. The Met antagonist capmatinib effectively mitigates lupus exacerbation. Furthermore, alkB homolog 5 (ALKBH5) targeting catalyzes m6A modification on FoxO1 messenger RNA in coding sequences and 3' untranslated regions. The up‐regulation of FoxO1 mediated by ALKBH5 overexpression in M‐MDSCs improves lupus progression. Finally, these correlations were confirmed in untreated patients with SLE.ConclusionOur findings indicate that effective inhibition of B cells mediated by the ALKBH5/FoxO1/Met axis in M‐MDSCs could offer a novel therapeutic approach to manage SLE.image
Features and Differences in Core Symptom Clusters in Home‐Based Hospice Patients With Advanced Cancer: A Network Analysis
Authors: Wei Yitao , Cheng Wan , Lu Yuanfeng , Zhu Zheng , Xu Guiru , Wu Hong , Lin Shaowei , Xiao Huimin 
Published: November 2024

ABSTRACTIntroductionPatients with terminal‐stage cancer frequently experience multiple symptoms simultaneously. Little is known about how core symptom clusters differ in advanced‐cancer patients with different survival expectancies receiving hospice care. To identify the core symptom clusters of hospice‐care cancer patients with different survival expectancies and compare the features of their symptom networks.MethodsIn this retrospective study, secondary data analysis was conducted. Records of 6946 patients with advanced cancer who received home‐based hospice care service in a hospice center from April 2001 to December 2020 were collected and analyzed using network analysis.ResultsThis analysis included 6946 patients with advanced cancer receiving hospice care. In patients with survival expectancies of 0–6 months, loss of appetite was identified as the core symptom (rs = 4.03, rb = 5.21, rc = 2.63), and five symptom clusters were identified. Malnutrition was the core symptom in patients with survival expectancies of 6–12 months (rs = 2.83, rb = 2.43, rc = 0.93), and nine symptom clusters were identified. Wasting syndrome was the core symptom cluster in two groups. The network density of symptoms in patients with < 6 months of survival expectancy (91.99) was higher than in patients with 6–12 months (28.39).ConclusionsNutrition impact symptoms are the core symptoms for home‐hospice care cancer patients with a survival period of 1 year or below. Moreover, hospice cancer patients with short survival expectancies have greater inter‐symptom impact.
Patient‐Initiated Nationwide Survey on Testing for Actionable Oncogenic Drivers in Non‐Small Cell Lung Cancer in Japan
Authors: Ikeda Satoshi , Hasegawa Kazuo , Kachi Kenta , Yanagisawa Akihiro , Kawakami Sachiko , Hamasaki Shinsuke , Watanabe Sachiko , Yoshikawa Aki , Takahama Takayuki , Nakagawa Kazuhiko 
Published: November 2024

ABSTRACTBackgroundPrevious reports indicated still low implementation rates of multigene testing for advanced non‐small cell lung cancer (NSCLC) in Japan.MethodsThis is a retrospective study launched at the initiative of lung cancer patients. Patients with stage IV NSCLC from January 2019 to December 2022 were investigated for testing of 8 actionable oncogenic drivers with targeted therapies available as of 2022.ResultsA total of 15,719 patients were included. Between 2019 and 2022, the percentage of patients who were not tested for any actionable oncogenic drivers remained the same, ranging from 21.5% to 33.1%. However, since late 2021, the percentage of patients tested for five or more actionable oncogenic drivers has increased. Across hospital categories and regions, the number of actionable oncogenic drivers tested was similar.ConclusionsThis patient‐initiated national survey in Japan reveals the recent nationwide increase in testing rates for actionable oncogenic drivers in Advanced NSCLC.
Melanoma Metabolism: Molecular Mechanisms and Therapeutic Implications in Cutaneous Oncology
Authors: Tan Isabella J. , Parikh Aarushi K. , Cohen Bernard A. 
Published: November 2024

ABSTRACTBackgroundMelanoma, a highly aggressive skin cancer, is characterized by rapid progression and a high metastatic potential, presenting significant challenges in clinical oncology. A critical aspect of melanoma biology is its metabolic reprogramming, which supports tumor growth, survival, and therapeutic resistance.ObjectiveThis review aims to explore the key molecular mechanisms driving metabolic alterations in melanoma and their implications for developing therapeutic strategies.MethodsA Pubmed search was conducted to analyze literature discussing key mechanisms of the Warburg effect, mitochondrial dysfunction, enhanced lipid metabolism, epigenetic modifications, and the tumor microenvironment.ResultsMetabolic reprogramming supports melanoma growth, proliferation, and survival. Understanding these complex metabolic dynamics provides valuable insights for developing targeted therapeutic strategies.ConclusionPotential therapeutic interventions aimed at disrupting melanoma metabolism highlight the promise of precision medicine in improving treatment outcomes in cutaneous oncology. By targeting metabolic vulnerabilities, novel treatment approaches could significantly enhance the clinical management and prognosis of melanoma.
Tissue‐Resident Macrophages in Cancer: Friend or Foe?
Authors: Chi Jianhua , Gao Qinglei , Liu Dan 
Published: November 2024

ABSTRACTIntroductionMacrophages are essential in maintaining homeostasis, combating infections, and influencing the process of various diseases, including cancer. Macrophages originate from diverse lineages: Notably, tissue‐resident macrophages (TRMs) differ from hematopoietic stem cells and circulating monocyte‐derived macrophages based on genetics, development, and function. Therefore, understanding the recruited and TRM populations is crucial for investigating disease processes.MethodsBy searching literature databses, we summarized recent relevant studies. Research has shown that tumor‐associated macrophages (TAMs) of distinct origins accumulate in tumor microenvironment (TME), with TRM‐derived TAMs closely resembling gene signatures of normal TRMs.ResultsRecent studies have revealed that TRMs play a crucial role in cancer progression. However, organ‐specific effects complicate TRM investigations. Nonetheless, the precise involvement of TRMs in tumors is unclear. This review explores the multifaceted roles of TRMs in cancer, presenting insights into their origins, proliferation, the latest research methodologies, their impact across various tumor sites, their potential and strategies as therapeutic targets, interactions with other cells within the TME, and the internal heterogeneity of TRMs.ConclusionsWe believe that a comprehensive understanding of the multifaceted roles of TRMs will pave the way for targeted TRM therapies in the treatment of cancer.
Geriatric Oral Health and Quality of Life Among the Indigenous Irula Tribes of Tamil Nadu
Authors: Sukumar Margret Beaula Alocious , Joseph Alex , Alhalabi Baidaa 
Published: November 2024

ABSTRACTObjectivesThis study aims to assess the oral health‐related quality of life (OHRQoL) among the Irula tribes and to know the factors influencing quality of life among the elderly irula tribes of Tamil Nadu.MethodsThis cross‐sectional study was conducted in the Northern district of Tamil Nadu, including 486 Irula individuals aged 65 and above. Participants were selected using a multistage sampling method. Data were collected through a structured questionnaire, including the Geriatric Oral Health Assessment Index (GOHAI) to evaluate OHRQoL. The study tool covered demographics, medical history, and oral health issues. Data analysis was performed using SPSS version 23, with logistic regression applied to account for confounders.ResultsThe sample primarily consisted of individuals aged 65–69 years (55.6%), with a predominance of females (76.3%). The majority were Hindu (94.9%) and lived in nuclear families (88.3%). Educational levels were low, with 66.5% being illiterate. Most participants were agricultural laborers (64.6%) and had low monthly incomes. GOHAI results revealed that many respondents faced significant oral health challenges, including difficulties with eating, speaking, and discomfort. Multivariate analysis showed that educational level significantly affected OHRQoL, with higher education correlating with better quality of life. Arthritis was associated with poorer OHRQoL, while other health conditions did not show significant impacts.ConclusionThe study highlights severe oral health issues among the Irula community, with significant physical and psychological impacts. Educational attainment plays a crucial role in OHRQoL, while arthritis notably affects quality of life. The findings emphasize the need for targeted oral health interventions and increased awareness in tribal communities to improve overall health outcomes. Further research in larger populations is necessary to comprehensively understand and address geriatric oral health needs.
Enhanced High‐Gain Switched Capacitor DC–DC Converter Optimizing Renewable Energy Integration
Authors: Gaurav  , Jayaram Nakka , Halder Sukanta , Kumar Uppalapati Sudheer , Patel Mitesh Kumar Bharat bhai 
Published: November 2024

ABSTRACTA novel high‐gain switched capacitor (HGSC) DC–DC converter for carbon neutral energy applications is presented in the scientific paper. It consists of two MOSFET switches, and utilization of a simultaneous switching approach for the switches enables simplified control. The switched capacitor (SC) technique is utilized to extract high gain from the proposed HGSC topology; the basic idea is periodic charging and discharging of the capacitor. The proposed HGSC topology operational mode is carried out in Continuous Conduction Mode (CCM) along with the steady‐state analysis, and different switching stages are discussed in detail. Then, an analysis is carried out to demonstrate the proposed HGSC converter's special feature with other high‐gain converters. An averaging state‐space technique is used to determine the suggested converter's dynamics performance, and a small signal analysis is used to verify its stability. Furthermore, the HGSC topology is thoroughly analyzed in terms of power losses. For comparing the practical efficiency of the designed converter, nonidealities voltage gain is derived. The maximum efficiency of 96.7% is obtained at 150 W output power with the help of the dSPACE 1104 controller. Whenever the HGSC converter is fed with an input voltage supply of 20 V. It generates output voltages between 140 and 240 V. Extensive experimental investigation is carried out on a 200 W laboratory prototype model to verify the practicability and feasibility of HGSC DC–DC converter topology.
Differences in the Effects of Three Water Elements on Vegetation in Different Climatic Regions: Insights From the Yellow River Basin, China
Authors: Jin Xiaohui , Fan Yumiao , Hu Yawei , Duan Hao , Yan Long , Liu Chang 
Published: November 2024

ABSTRACTThe effects of water on vegetation have always been a concern. It is an important support as well as a major limiting factor with respect to vegetation growth. By analysing the spatiotemporal changes and correlations between precipitation (PRE), soil moisture (SM), vapour pressure deficit (VPD) and normalized difference vegetation index (NDVI) in the Yellow River Basin, we explored the different effects of three water elements on vegetation in different climatic regions. Our findings reveal the following: (1) NDVI and the three water elements report an increasing trend in the Yellow River Basin, with NDVI increasing most significantly. 92.1% of the Yellow River Basin showed an increase in NDVI. (2) Vegetation in the Yellow River Basin was most positively affected by PRE, followed by SM and VPD. PRE mainly affected the natural vegetation on both sides of the boundary between the arid and semi‐arid regions and the semi‐humid regions. SM mainly affected the natural vegetation in the arid and semi‐arid regions, whereas VPD mainly affected the crops in the irrigation areas, and the irrigation areas in arid regions were affected the most. These findings contribute to a deeper understanding of the relationship between water elements and vegetation.
The impact of exposure to green or bluespace on dietary intake and food choices among adults—A systematic literature review
Authors: Gilbourne Claire A. , Scarry Alan , Tierney Audrey C. , O’Connor Eibhlís M. 
Published: November 2024

AbstractExtensive research has shown that spending time in natural greenspaces has a positive impact on health. However, there is limited evidence regarding potential factors that may influence these effects. This review aimed to assess the strength of the evidence and potential impact of exposure to green and bluespaces on dietary outcomes in adults. Inclusion criteria for the review were based on the PICO criteria. Following PRISMA guidelines, an initial search of five databases was conducted: CINAHL, GreenFILE, AMED, Medline, and PubMed, accessed on 14th June 2021 and augmented by an updated rerun in January 2024. All studies used the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Analytical Cross‐Sectional Studies for quality assessment. Due to heterogeneity, a narrative synthesis was conducted to evaluate the relationships between the included studies. Four observational studies that reported diet‐related outcomes were included in the review, and participants within the studies ranged from 554 to >350,000 participants. Other health outcomes, including physical activity and obesity, were also reported. Two studies found that dietary patterns were not correlated with exposure to greenspace. Due to the small number of articles retrieved and the paucity of evidence, the findings must be interpreted cautiously. In conclusion, further research is essential to clarify the intricate mechanisms involved in greenspace‐related health benefits. Additionally, investigating the specific greenspace attributes influencing adult dietary intake and food choices is warranted. When devising public health interventions, it is crucial to account for the substantial health advantages associated with various socioeconomic groups.
A bottom‐up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors
Authors: Rodriguez‐Iglesias Noelia , Paris Iñaki , Valero Jorge , Cañas‐Zabala Lorena , Carretero Alejandro , Hatje Klas , Zhang Jitao David , Patsch Christoph , Britschgi Markus , Gutbier Simon , Sierra Amanda 
Published: November 2024

AbstractPhagocytosis is an indispensable function of microglia, the brain professional phagocytes. Microglia is particularly efficient phagocytosing cells that undergo programmed cell death (apoptosis) in physiological conditions. However, mounting evidence suggests microglial phagocytosis dysfunction in multiple brain disorders. These observations prompted us to search for phagocytosis modulators (enhancers or inhibitors) with therapeutic potential. We used a bottom‐up strategy that consisted on the identification of phagocytosis modulators using phenotypic high throughput screenings (HTSs) in cell culture and validation in organotypic cultures and in vivo. We performed two complementary HTS campagnes: at Achucarro, we used primary cultures of mouse microglia and compounds of the Prestwick Chemical Library; at Roche, we used human iPSC derived macrophage‐like cells and a proprietary chemo‐genomic library with 2200 compounds with known mechanism‐of‐action. Next, we validated the more robust compounds using hippocampal organotypic cultures and identified two phagocytosis inhibitors: trifluoperazine, a dopaminergic and adrenergic antagonist used as an antipsychotic and antineoplastic; and deoxytubercidin, a ribose derivative. Finally, we tested whether these compounds were able to modulate phagocytosis of apoptotic newborn cells in the adult hippocampal neurogenic niche in vivo by administering them into the mouse hippocampus using osmotic minipumps. We confirmed that both trifluoperazine and deoxytubercidin have anti‐phagocytic activity in vivo, and validated our bottom‐up strategy to identify novel phagocytosis modulators. These results show that chemical libraries with annotated mechanism of action are an starting point for the pharmacological modulation of microglia in drug discovery projects aiming at the therapeutic manipulation of phagocytosis in brain diseases.
Advantages of regional development—A study on poverty alleviation in contiguous destitute areas
Authors: Hongyu Du 
Published: November 2024

AbstractThe 2011–2020 period is the final stage of poverty alleviation in China, which emphasizes regional development. Using county‐level panel data from 2006 to 2015, we explore the impact of regional poverty alleviation policy on economic growth of contiguous destitute areas (CDAs) in China. The results show that since 2012, economy in CDAs has developed rapidly, that GDP per capita has significantly improved by 5.4% and that county GDP has significantly improved by 6.6%. The regional strategy enhances construction of infrastructure and ecological projects, and gives full play to exert synergy effect, which doubles economic growth. The impact of economic growth is heterogeneous in different regional scales, regional inequities, geographic locations, and population sizes, and lasting even if counties are lifted out of poverty. Our findings recommend regional collaboration and highlight the importance of ecological protection in poverty alleviation.