bluuebunny/crossref_metadata_2025_split huggingface dataset:
OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels
Authors: Murthy Swetha E. , Dubin Adrienne E. , Whitwam Tess , Jojoa-Cruz Sebastian , Cahalan Stuart M. , Mosavi Seyed Ali Reza , Ward Andrew B. , Patapoutian Ardem 
Published: September 2018

IntroductionMechanotransduction, the conversion of mechanical cues into biochemical signals, is crucial for many biological processes in plants and animals1,2. In mammals, some mechanosensory processes such as touch sensation and vascular development are mediated by the PIEZO family of mechanically activated (MA) ion channels3-5. In plants, the impact of gravity or soil properties on root development, wind on stem growth, and turgor pressure on plant-cell size and shape are proposed to involve activation of MA ion channels6,7. Homologues of the bacterial MA channel MscS (MSLs) exist in plants, and MSL8 is shown to be involved in pollen hydration8; however, the identity of the MA channels required for most mechanotransduction processes in plants have remained elusive9. Here, we identify various members of the 15 OSCA proteins from Arabidopsis thaliana (previously reported as hyperosmolarity sensors10,11) as MA ion channels. Purification and reconstitution of OSCA1.2 in liposomes induced stretch-activated currents, suggesting that OSCAs are inherently mechanosensitive, pore-forming ion channels. This conclusion is confirmed by a high-resolution electron microscopy structure of OSCA1.2 described in a companion paper12. Beyond plants, we present evidence that fruit fly, mouse, and human TMEM63 family of proteins, homologues of OSCAs, induce MA currents when expressed in naïve cells. Our results suggest that OSCA/TMEM63 proteins are the largest family of MA ion channels identified, and are conserved across eukaryotes. We anticipate that further characterization of OSCA isoforms which have diverse biophysical properties, will help gain substantial insight on the molecular mechanism of MA ion channel gating and permeation. OSCA1.1 mutant plants have impaired leaf and root growth under stress, potentially linking this ion channel to a mechanosensory role11. We expect future studies to uncover novel roles of OSCA/TMEM63 channels in mechanosensory processes across plants and animals.
Dynamic multi-attribute decision-making method with three-parameter interval grey number based on the prospect theory
Authors: Li Ye , Zhang Dongxing 
Published: September 2018

Purpose
The purpose of this paper is to propose a dynamic multi-attribute decision-making method based on the prospect theory for dealing with the dynamic multi-attribute decision-making problem with three-parameter interval grey number.

Design/methodology/approach
First, the kernel and comparison rule of three-parameter interval grey numbers are defined, which are the basis of collecting and sorting grey numbers. Next, the prospect value function is determined in view of the decision-making information with different time points as the reference points. Then, an optimal model for solving the attribute weight and time weight is constructed based on the grey entropy principle.

Findings
The paper provides a dynamic grey interrelation decision method based on the prospect theory with three-parameter interval grey number, and the example analysis shows that the method proposed in this paper has validity and rationality.

Research limitations/implications
If we have a better understanding of the weights of different reference points, it is possible to receive a more reasonable expression for the comprehensive prospect utility value function.

Practical implications
The paper provides a grey interrelation decision method based on the prospect theory, which can help the decision maker deal with the dynamic multi-attribute decision-making problems under the uncertain environment.

Originality/value
The paper proposes the kernel and ranking method of three-parameter interval grey number, and uses different time points as the reference points to define the prospect value function. Furthermore, this paper structures a dynamic grey interrelation decision method with three-parameter interval grey number based on the prospect theory.
Micropolitical Dynamics of Interlingual Translation Processes in an MNC Subsidiary
Authors: Ciuk Sylwia , James Philip , Śliwa Martyna 
Published: September 2018

AbstractDrawing on a deep single case study of a Polish subsidiary of a US‐headquartered pharmaceutical multinational company (MNC), the paper contributes to the study of power and politics in international business (IB) by advancing understanding of the interactional and processual dynamics of micropolitics in MNCs, which supplements the current dominant actor‐centred approach. The paper advances understanding of translation in IB by demonstrating how interlingual translation can be deliberately used as a management tool to pre‐empt resistance and promote managerially desired attitudes and behaviours at the subsidiary level. It highlights how hitherto largely ignored processes of interlingual translation provide an important internal forum for the exercise of power and micropolitics. The paper puts forward an emergent model of the micropolitical dynamics of interlingual translation and demonstrates how subsidiary managers can use interlingual translation to support and oppose the views of both corporate and local managerial colleagues, and thereby influence how HQ‐level decisions will be received by subsidiary‐level employees.
Circulating tumor cell levels and carcinoembryonic antigen: An improved diagnostic method for lung adenocarcinoma
Authors: Ding Cheng , Zhou Xiaofei , Xu Chun , Chen Jun , Ju Shen , Chen Tengfei , Liang Zhipan , Cui Zihan , Li Chang , Zhao Jun 
Published: September 2018

BackgroundThe aim of this study was to determine a correlation between benign and malignant lung solitary pulmonary nodules (SPN), and analyze the association between circulating tumor cell (CTC) levels and different subtypes of lung adenocarcinoma.MethodsA total of 200 patients (80 with SPNs and 120 diagnosed with lung cancer) were included in the study. The CTC levels were quantified by identifying the folate receptor on the surface of tumor cells; clinical tumor specific markers were detected by biochemical immunization. The content of peripheral blood CTCs in benign and malignant lung SPN patients was detected and the differences in preoperative CTC levels in different pathological subtypes were analyzed. Based on the collected data, receiver operating characteristic curves were calculated and the rate of lung cancer was predicted.ResultsThe peripheral blood CTC levels in patients with malignant lung SPNs were higher than in patients with benign SPNs. The maximum nodule diameter, carcinoembryonic antigen, and CTC levels were independent risk factors for malignant lung SPNs. The peripheral blood CTC levels in patients with stage III–IV lung adenocarcinoma were higher than in stage I–II patients. The peripheral blood CTC levels in patients with microinvasive and invasive adenocarcinoma were higher than in adenocarcinoma in situ patients. The CTC levels in the peripheral blood of patients with maximum tumor diameter > 2 cm were higher than in patients with tumors < 2 cm.ConclusionThe detection of CTCs can be used as a biomarker for screening SPNs and diagnosing early‐stage lung cancer. Using the combination of CTC levels and CEA significantly improves the efficacy of lung adenocarcinoma diagnosis.
Dividend payout and executive compensation: theory and evidence from New Zealand
Authors: Anderson Warwick , Bhattacharyya Nalinaksha , Morrill Cameron , Roberts Helen 
Published: September 2018

AbstractUsing a model based on Bhattacharyya (2007), we predict a positive (negative) relationship between the earnings retention ratio (dividend payout ratio) and managerial compensation. We use tobit regression to analyse data for New Zealand firms' dividend payouts over the period 1997–2015 and find results consistent with Bhattacharyya (2007). These results hold when the definition of payout is modified to incorporate both common dividends and common share repurchases. Our results indicate that corporate dividend policy among New Zealand firms is perhaps best understood by considering the dividend payout ratio, rather than the level of, or changes in, cash dividends alone.
Choroidal structural analysis and vascularity index in retinal dystrophies
Authors: Wei Xin , Mishra Chitaranjan , Kannan Naresh Babu , Holder Graham E. , Khandelwal Neha , Kim Ramasamy , Agrawal Rupesh 
Published: September 2018

AbstractPurposeTo assess choroidal structural changes in patients with retinal dystrophies using choroidal vascularity index (CVI), a novel optical coherence tomography (OCT) based tool.MethodsThis retrospective study included 26 patients with retinal dystrophies (17 with retinitis pigmentosa, four with Stargardt disease, three with cone‐rod dystrophy, one each with Best disease and Bietti crystalline dystrophy) and 32 healthy controls. Subfoveal OCT images were used for analysis. Mean CVI was compared between retinal dystrophy and control group, as well as among the retinal dystrophy subgroups.ResultsMean CVI in eyes with retinal dystrophies was 52 ± 9% and it was significantly lower compared to that in normal eyes (70 ± 3%, p < 0.001). The differences among subgroups of retinal dystrophy were not statistically significant (p = 0.084). All types of retinal dystrophy were associated with lower CVI (all p < 0.001), after adjusting for age, gender, visual acuity and duration of symptoms. Older age was also shown to be independently associated with lower CVI (p = 0.012). Gender, visual acuity (VA) and duration of symptoms did not significantly affect CVI.ConclusionDecreased choroidal vascularity was seen in eyes with retinal dystrophies. (CVI) may be a helpful tool in monitoring choroidal involvement in retinal dystrophies.
Review article: the relationship between obesity, bariatric surgery, and inflammatory bowel disease
Authors: Cañete Fiorella , Mañosa Míriam , Clos Ariadna , Cabré Eduard , Domènech Eugeni 
Published: September 2018

SummaryBackgroundThe convoluted relationship between obesity, bariatric surgery and inflammatory bowel disease (IBD) is of increasing interest.AimTo analyse evidence regarding the role of bariatric surgery in the development of de novo IBD and its impact on clinical outcomes and safety in patients with established IBD.MethodsA PubMed/Medline search was performed to identify studies reporting the development of IBD after bariatric surgery and the outcomes of IBD patients after bariatric surgery.ResultsEighty patients were reported to have developed de novo IBD after bariatric surgery (21% ulcerative colitis [UC], 75% Crohn's disease [CD]), mostly females. Roux‐en‐Y gastric bypass was the most frequent bariatric technique (80%). Symptoms related to IBD occurred within 1 month and 16 years after surgery. Regarding patients with known IBD undergoing bariatric surgery, 60 patients (35 CD, 24 UC, and 1 unclassified colitis) have been reported. Sleeve gastrectomy was the most frequent bariatric procedure, particularly in CD patients. Acute flares after surgery were observed in only four UC patients. In addition, two retrospective population‐based studies described perioperative outcomes of bariatric surgery on IBD patients, demonstrating only a significant increase in small bowel obstruction in these patients.ConclusionsBariatric surgery in carefully selected patients with established IBD is technically feasible and probably safe. Development of de novo IBD should be taken into account in individuals with previous bariatric surgery who develop diarrhoea, anaemia or excessive weight loss.
Child protection and fathering where there is domestic violence: Contradictions and consequences
Authors: Smith Joanie , Humphreys Cathy 
Published: September 2018

AbstractChildren live in different contexts of protection and vulnerability when exposed to domestic violence. The negative impacts for many children are consistent and widely acknowledged. However, the implication that this requires men who use violence to address their fathering has been slower to emerge. This article draws from 69 in‐depth qualitative interviews with men, women, and workers across four men's behaviour change programmes in rural Victoria, Australia. Particular attention is given to men's attitudes to their fathering and the formal and informal consequences they experienced as a result of their violence and its impact on their fathering. Although most men came to recognize that their violence impacted their children, they failed to make the connection that the involvement of statutory child protection services in their lives was a direct consequence of their abusive behaviour. This article explores this disconnection by fathers who use violence, their attitude to the involvement of statutory child protection services, and identifies the implications for social work practitioners in addressing this issue.
Unspoken Rules: Resolving Underdetermination With Closure Principles
Authors: Nichols Shaun , Gaus Jerry 
Published: September 2018

AbstractWhen people learn normative systems, they do so based on limited evidence. Many of the possible actions that are available to an agent have never been explicitly permitted or prohibited. But people will often need to figure out whether those unspecified actions are permitted or prohibited. How does a learner resolve this incompleteness? The learner might assume if an action‐type is not expressly forbidden, then acts of that type are permitted. This closure principle is one of Liberty. Alternatively, the learner might assume that if an action‐type is not expressly permitted, then acts of that type are prohibited. This closure principle would be one of Residual Prohibition (Mikhail, 2011). On the basis of principles of pedagogical sampling (e.g., Shafto, Goodman, & Griffiths, ), we predicted that participants would infer the Liberty Principle (LP) when trained on prohibitions, and they would infer the Residual Prohibition Principle when trained on permissions. This is exactly what we found across several experiments. We also found a bias in favor of Liberty insofar as participants trained on both a prohibition and a permission rule tended still to infer the LP. However, we also found that if an action is potentially harmful, this diminishes the tendency to infer the LP.
From understanding tooth development to bioengineering of teeth
Authors: Thesleff Irma 
Published: September 2018

Remarkable breakthroughs in the fields of developmental biology and stem cell biology during the last 15 yr have led to a new level of understanding regarding how teeth develop and how stem cells can be programmed. As a result, the possibilities of growing new teeth and of tooth bioengineering have been explored. Currently, a great deal is known about how signaling molecules and genes regulate tooth development, and modern research using transgenic mouse models has demonstrated that it is possible to induce the formation of new teeth by tinkering with the signaling networks that govern early tooth development. A breakthrough in stem cell biology in 2006 opened up the possibility that a patient′s own cells can be programmed to develop into pluripotent stem cells and used for building new tissues and organs. At present, active research in numerous laboratories around the world addresses the question of how to program the stem and progenitor cells to develop into tooth‐specific cell types. Taken together, the remarkable progress in developmental and stem cell biology is now feeding hopes of growing new teeth in the dental clinic in the not‐too‐distant future.
Pricing joint use of municipal services: Theoretical perspectives and regulatory issues
Authors: Valkama Pekka , Bailey Stephen J. 
Published: September 2018

AbstractThis paper analyses price regulation of inter‐municipal contracts in Finland to demonstrate interpretative problems of regulatory rules specifying full‐cost or market prices and, by so doing, deepen understanding of the theoretical underpinnings for pricing collaborative municipal services. It considers how to price inter‐municipal services taking into account the specific socio‐economic nature of inter‐municipal cooperation, including both financial and non‐financial objectives, through a new joint‐use pricing model of municipal services that challenges the supremacy of full‐cost pricing requirements in cases of inter‐municipal collaborative contracting. Acknowledging limitations and benefits, it concludes European Single Market rules militate against municipal discretion and localism.
Predicting fracture of solder joints with different constraint factors
Authors: Nourani Amir , Mirmehdi Sadegh , Farrahi Gholamhossein , Soroush Farid 
Published: September 2018

AbstractDouble cantilever beam (DCB) specimens of 2.5‐mm‐long SAC305 solder joints were prepared with thickness of copper adherends varying from 8 to 21 mm each. The specimens were tested under mode I loading conditions (ie, pure opening mode with no shear component of loading) with a strain rate of 0.03 second−1. The measured fracture load was used to calculate the critical strain energy release rate for crack initiation, Jci, in each case. Fracture behaviour showed a significant dependence on the adherend thickness; the Jci and plastic deformation of the solder at crack initiation decreased significantly with increase in adherend thickness. This behaviour was attributed to changes in stress distribution along the solder layer when the adherend thickness was varied. The capability of Jci as a property was then assessed to predict the fracture load of solder joints in specimens with different constraint levels caused by variations in adherend thicknesses. In light of the results obtained, a cohesive zone model (CZM) was developed to predict the fracture load of solder joints as a function of adherend thickness. Finally, a CZM with a single set of parameters was established to predict the fracture loads for all the cases. It was concluded that CZM was a better methodology to account for changes in degree of joint constraint imposed by bonding adherends.
HISTORIA MAGISTRA VITAE, INTERRUPTING: THUCYDIDES AND THE AGONISTIC TEMPORALITY OF ANTIQUITY AND MODERNITY
Authors: LIANERI ALEXANDRA 
Published: September 2018

ABSTRACTIn this essay I discuss Koselleck's thesis on the dissolution of historia magistra vitae in modernity with a view to exploring how the modern historiographical engagement with Thucydides entails qualifications of this argument. Focusing on Barthold Georg Niebuhr's contextualization of Thucydides in a new temporality of “ancient and modern history,” I examine how modernity is caught between conflicting notions of its own prehistory, and that this conflict suggests that the forward‐leaping qualities of Neuzeit were co‐articulated with other temporal notions, and particularly an idea of historical exemplarity associated with historia magistra vitae. This plurality of times highlights an agonistic temporality linking antiquity and modernity: a model of conflicting times inscribed in a dialogue through which modern historiography interrupted the “useful” history of antiquity, while simultaneously being itself interrupted by it. By following this dialogue, I seek to test two interrelated hypotheses: a) that modernity produced a multitemporal scheme in which the ideas of differential time and the future were intertwined with a notion of historia magistra vitae as meaningful and sense‐bearing time; and b) that contradictions in this scheme arising from the modern confrontation with Thucydides's poetics challenges the opposition between historia magistra vitae and modern historical sense and configures a temporality that is self‐agonistic in the sense that it confronts historical actors before and beyond the terms through which they may be able to give it meaning. Formulated as a poetics of the possible, this notion is approached as a corrective alternative to the modern consideration of the future as distanced from the space of experience, but nonetheless as grounded in actuality and therefore largely mastered by human knowledge and action.
Evaluation of durability and cleanability performances of protective treatments for lapped ceramic tiles—Part 1
Authors: Lucchese Beatrice , Rambaldi Elisa , Engels Marcel , Bignozzi Maria C. 
Published: September 2018

AbstractThe aim of this work was to evaluate the durability, in real pedestrian traffic condition, of lapped porcelain stonewares with surface protective treatments able to fill up pores opened by the lapping process. In recent years, the durability of ceramic surfaces has become a key factor during the design process. The knowledge of the material durability is important to define the behavior of tiles in use. Standard procedures for indirectly assessing durability are already available (ie, abrasion tests, staining resistance, chemical resistance), however, a standard method of aging in real condition is still lacking. In this study, a durability test was performed in real pedestrian traffic condition by fixing tiles on floors to evaluate the surface characteristics after 6 and 12 months. The surface characteristics were analyzed before and after the durability tests and in terms of microstructural observations and determination of surface porosity. In particular a durability index has been estimated as ratio of pores filled by dirtiness respect to the original surface porosity (before aging). Results of durability index showed good correlation between aging duration and kind of treatments (industrially applied and/or manually applied).
miR‐21 modification enhances the performance of adipose tissue‐derived mesenchymal stem cells for counteracting urethral stricture formation
Authors: Feng Zongcheng , Chen Hongrun , Fu Taozhu , Zhang Lianfeng , Liu Yushan 
Published: September 2018

AbstractThe treatment of complicated long segment strictures remains to a challenge, and the substitution urethroplasty treatment is often accompanied by subsequent tissue fibrosis and secondary stricture formation. In situ injection of human adipose tissue‐derived stem cells (hADSC) could potential be applied for prevention of urethral fibrosis, but the cells transplantation alone may be insufficient because of the complicated histopathological micro‐environmental changes in the injury site. This study investigated whether miR‐21 modification can improve the therapeutic efficacy of ADSCs against urethral fibrosis to limit urethral stricture recurrence. MiR‐21‐modified ADSCs (miR‐21) were constructed via lentivirus‐mediated transfer of pre‐miR‐21 and GFP reporter gene. In vitro results suggested that miR‐21 modification can increase the angiogenesis genes expression of ADSCs and enhance its anti‐oxidative effects against reactive oxygen species (ROS) damage. In vivo results showed that miR‐21 modification contributes to increased urodynamic parameters and better formation of the epithelium and the muscle layer as compared to ADSCs transplantation alone groups. The results demonstrated that miR‐21 modification in ADSCs could improve urethral wound healing microenvironment, enhance stem cell survival through ROS scavenging and promote the neovascularization via regulating angiogenic genes expression, which eventually increase the ADSCs' therapeutic potential for urethral wound healing.