bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing bird avoidance of high-contrast lights using a choice test approach: implications for reducing human-induced avian mortality
Authors: Goller Benjamin , Blackwell Bradley F. , DeVault Travis L. , Baumhardt Patrice E. , Fernández-Juricic Esteban 
Published: September 2018

BackgroundAvian collisions with man-made objects and vehicles (e.g., buildings, cars, airplanes, power lines) have increased recently. Lights have been proposed to alert birds and minimize the chances of collisions, but it is challenging to choose lights that are tuned to the avian eye and can also lead to avoidance given the differences between human and avian vision. We propose a choice test to address this problem by first identifying wavelengths of light that would over-stimulate the retina using species-specific perceptual models and by then assessing the avoidance/attraction responses of brown-headed cowbirds to these lights during daytime using a behavioral assay.MethodsWe used perceptual models to estimate wavelength-specific light emitting diode (LED) lights with high chromatic contrast. The behavioral assay consisted of an arena where the bird moved in a single direction and was forced to make a choice (right/left) using a single-choice design (one side with the light on, the other with the light off) under diurnal light conditions.ResultsFirst, we identified lights with high saliency from the cowbird visual perspective: LED lights with peaks at 380 nm (ultraviolet), 470 nm (blue), 525 nm (green), 630 nm (red), and broad-spectrum (white) LED lights. Second, we found that cowbirds significantly avoided LED lights with peaks at 470 and 630 nm, but did not avoid or prefer LED lights with peaks at 380 and 525 nm or white lights.DiscussionThe two lights avoided had the highest chromatic contrast but relatively lower levels of achromatic contrast. Our approach can optimize limited resources to narrow down wavelengths of light with high visual saliency for a target species leading to avoidance. These lights can be used as candidates for visual deterrents to reduce collisions with man-made objects and vehicles.
Variably protease‐sensitive prionopathy presenting within ALS/FTD spectrum
Authors: Vicente‐Pascual Mikel , Rossi Marcello , Gámez Josep , Lladó Albert , Valls Josep , Grau‐Rivera Oriol , Ávila Polo Rainiero , Llorens Franc , Zerr Inga , Ferrer Isidre , Nos Carlos , Parchi Piero , Sánchez‐Valle Raquel , Gelpí Ellen 
Published: September 2018

AbstractWe report clinico‐pathological features of a 65‐year‐old woman and a 56‐year‐old man with a 5‐year clinical history who had clinical and neuropathological characteristics of upper and lower motor neuron disease consistent with amyotrophic lateral sclerosis, and a frontotemporal atrophy pattern in case 2 without TDP‐43 pathology. Instead, spongiform change and pathological prion protein deposits were observed in several brain regions. No prion protein gene mutations were found. Western blot analysis showed a five‐band profile compatible with variably protease‐sensitive prionopathy. We conclude that this disease can display prolonged disease duration and clinico‐pathological features within the ALS/FTLD spectrum.
Anti–RNPC‐3 (U11/U12) Antibodies in Systemic Sclerosis in Patients With Moderate‐to‐Severe Gastrointestinal Dysmotility
Authors: McMahan Zsuzsanna H. , Domsic Robyn T. , Zhu Lei , Medsger Thomas A. , Casciola‐Rosen Livia , Shah Ami A. 
Published: September 2018

ObjectiveTo examine the association of anti–RNPC‐3 antibodies in patients with systemic sclerosis (scleroderma or SSc) with selected gastrointestinal (GI) tract complications.MethodsSera from patients with SSc with or without severe GI dysfunction (total parenteral nutrition dependence) from the Johns Hopkins Scleroderma Center were screened for anti–RNPC‐3 antibodies. We then examined anti–RNPC‐3–positive cases and negative SSc controls from the University of Pittsburgh and the University of Pittsburgh Medical Center (UPMC) scleroderma cohort to confirm our findings and to examine whether specific GI features were associated with anti–RNPC‐3 antibodies.ResultsIn the discovery cohort, patients with SSc with severe GI dysfunction (n = 37) and without GI dysfunction (n = 38) were screened for anti–RNPC‐3 antibodies. The former were more likely to have anti–RNPC‐3 antibodies (14% versus 3%; P = 0.11). In the Pittsburgh cohort, moderate‐to‐severe GI dysfunction (Medsger GI score ≥2) was present in 36% of anti–RNPC‐3–positive patients versus 15% of anti–RNPC‐3–negative patients (P ≤ 0.01). Anti–RNPC‐3–positive patients were more likely to be male (31% versus 15%; P = 0.04), African American (18% versus 6%; P = 0.02), have esophageal dysmotility (93% versus 62%; P < 0.01), and interstitial lung disease (ILD) (77% versus 35%; P < 0.01). After adjusting for relevant covariates and potential confounders, moderate‐to‐severe GI disease was associated with anti–RNPC‐3 antibodies (odds ratio [OR] 3.8 [95% confidence interval (95% CI) 1.0–14.3]), and ILD trended toward significance (OR 2.8 [95% CI 1.0–8.2]).ConclusionPatients with SSc and anti–RNPC‐3 antibodies are more likely to be male and African American and to have moderate‐to‐severe GI disease and ILD. Further studies on larger patient cohorts may be helpful in further defining subsets of patients with SSc at risk for severe GI involvement.
SERS Nanoprobes in Biologically Raman Silent Region for Tumor Cell Imaging and In Vivo Tumor Spectral Detection in Mice
Authors: Liang Duanwei , Jin Qingqing , Yan Ning , Feng Jie , Wang Jing , Tang Xinjing 
Published: September 2018

AbstractSurface enhanced Raman scattering (SERS) is widely used in biological applications due to its high sensitivity and deep tissue penetration. Most SERS nanoprobes with fluorophore attachments have Raman signals between 1400 and 1700 cm−1. Here, a series of SERS nanoprobes anchored with alkyne moieties in the biologically Raman‐silent region through CAu bond formation is prepared. To achieve target‐specific recognition, two nucleic acid aptamers (AS1411 and MUC1) and two control oligonucleotides (C‐con and T‐con) with the same alkyne moiety are also attached on the Au surface, respectively. Both aptamer‐charged SERS nanoprobes successfully target MCF‐7 cells, which could possibly achieve cross‐check of target cells and overcome the possible false positive results. And the limit of detection reaches up to five cancer cells, which has great potential in circulating tumor cells detection. Further in vivo studies indicate that both SERS nanoprobes are successfully employed to target tumors in living mice with an obvious signal (≈2205 cm−1) at the Raman silent region after tail intravenous injection for the first time.
Printing of Responsive Photonic Cellulose Nanocrystal Microfilm Arrays
Authors: Zhao Tianheng H. , Parker Richard M. , Williams Cyan A. , Lim Kevin T. P. , Frka‐Petesic Bruno , Vignolini Silvia 
Published: September 2018

AbstractInteractive materials capable of changing appearance upon exposure to external stimuli, such as photonic inks, are generally difficult to achieve on a large scale as they often require self‐assembly processes that are difficult to control macroscopically. Here this problem is overcome by preparing arrays of cellulose nanocrystal (CNC) microfilms from discrete nanoliter sessile droplets. The obtained microfilms show extremely uniform and intense color, enabling exceptional consistency in optical appearance across the entire array. The color can be controlled through the initial ink formulation, enabling the printing of polychromatic dot‐matrix images. Moreover, the high surface‐to‐volume ratio of the microfilms and the intrinsic hydrophilicity of the natural building block allow for a dramatic real‐time colorimetric response to changes in relative humidity. The printed CNC microfilm arrays overcome the existing issues of scalability, optical uniformity, and material efficiency, which have held back the adoption of CNC‐based photonic materials in cosmetics, interactive‐pigments, or anticounterfeit applications.
The Interaction between Quantum Dots and Graphene: The Applications in Graphene‐Based Solar Cells and Photodetectors
Authors: Wu Jianghong , Lu Yanghua , Feng Sirui , Wu Zhiqian , Lin Shuyuan , Hao Zhenzhen , Yao Tianyi , Li Xinming , Zhu Hongwei , Lin Shisheng 
Published: September 2018

AbstractGraphene with a series of neoteric electronic and optical properties is an intriguing building block for optoelectronic devices. Over the past decade, graphene‐based solar cells (SCs) and photodetectors (PDs) which can convert light signals to electrical signals have received burgeoning exploration. However, limited light absorption hampers the performance of these devices. Quantum dots (QDs) possess a strong confinement effect, a large exciton energy, and long exciton lifetime, enhancing the interaction between incident light and graphene. Especially, as the density of states near the Dirac point of graphene is ultralow, it is easy to modify the Fermi level of graphene by inserting quantum dots at the interface between graphene and light, thereby enhancing the performance of graphene‐based optoelectronic devices. The characteristics of QDs and crucial physical mechanisms of the interaction and energy transfer in QDs/graphene nanohybrids are systematically addressed. The factors influencing the efficiency of energy transfer are also analyzed quantitatively. Moreover, the experimental process of QD‐enhanced technologies for SCs, photoconductors, phototransistors, and photodiode PDs is reviewed. Eventually, a conclusion is given and the remaining challenges and future development for QDs/2D materials hybrid systems is discussed. Possible steps toward large‐scale commercial applications and integration into optoelectronic networks are suggested.
Free‐Standing Electrodes Derived from Metal–Organic Frameworks/ Nanofibers Hybrids for Membrane Capacitive Deionization
Authors: Ding Meng , Bannuru Kranthi K. R. , Wang Ye , Guo Lu , Baji Avinash , Yang Hui Ying 
Published: September 2018

AbstractMembrane capacitive deionization is considered as a promising technology for water treatment with their high efficiency, low capital cost, and environmental friendliness. However, the complex fabrication process of membrane capacitive deionization electrodes mainly hinders its viability in large‐scale applications. In this study, a facile and general method to prepare free‐standing electrodes for membrane capacitive deionization with an excellent electrosorption performance is presented. Electrospun nanofibers enclosing zinc‐based nanoparticles are fabricated as the templates. After pyrolysis, the nitrogen‐doped carbon nanofiber hybrids with high conductivity and a high surface area can be obtained readily. The carbon electrode material is able to achieve a salt adsorption capacity of 43.3 mg g−1 at 1.4 V in 1000 mg L−1 NaCl aqueous solution. Overall, the carbon nanofiber hybrids electrode prepared by electrospinning and pyrolysis shows a great potential in membrane capacitive deionization for industrial applications.
Stereolithography for Personalized Left Atrial Appendage Occluders
Authors: Robinson Sanlin S. , Aubin Cameron A. , Wallin Thomas J. , Gharaie Saleh , Xu Patricia A. , Wang Kaiyang , Dunham Simon N. , Mosadegh Bobak , Shepherd Robert F. 
Published: September 2018

AbstractAdvancements in 3D additive manufacturing have spurred the development of effective patient‐specific medical devices. Prior applications are limited to hard materials, however, with few implementations of soft devices that better match the properties of natural tissue. This paper introduces a rapid, low cost, and scalable process for fabricating soft, personalized medical implants via stereolithography of elastomeric polyurethane resin. The effectiveness of this approach is demonstrated by designing and manufacturing patient‐specific endocardial implants. These devices occlude the left atrial appendage, a complex structure within the heart prone to blood clot formation in patients with atrial fibrillation. Existing occluders permit residual blood flow and can damage neighboring tissues. Here, the robust mechanical properties of the hollow, printed geometries are characterized and stable device anchoring through in vitro benchtop testing is confirmed. The soft, patient‐specific devices outperform non‐patient‐specific devices in embolism and occlusion experiments, as well as in computational fluid dynamics simulations.
Development of Biocompatible HA Hydrogels Embedded with a New Synthetic Peptide Promoting Cellular Migration for Advanced Wound Care Management
Authors: Wang Sun Young , Kim Hyosuk , Kwak Gijung , Yoon Hong Yeol , Jo Sung Duk , Lee Ji Eun , Cho Daeho , Kwon Ick Chan , Kim Sun Hwa 
Published: September 2018

AbstractIn the past few years, there have been many efforts underway to develop effective wound healing treatments for traumatic injuries. In particular, wound‐healing peptides (WHPs) and peptide‐grafted dressings hold great promise for novel therapeutic strategies for wound management. This study reports a topical formulation of a new synthetic WHP (REGRT, REG) embedded in a hyaluronic acid (HA)‐based hydrogel dressing for the enhancement of acute excisional wound repair. The copper‐free click chemistry is utilized to form biocompatible HA hydrogels by cross‐linking dibenzocyclooctyl‐functionalized HA with 4‐arm poly(ethylene glycol) (PEG) azide. The HA hydrogels are grafted with the REG peptide, a functional derivative of erythroid differentiation regulator1, displaying potent cell motility‐stimulating ability, thus sustainably releasing physiologically active peptides for a prolonged period. Combined with the traditional wound healing benefits of HA, the HA hydrogel embedded REG (REG‐HAgel) accelerates re‐epithelialization in skin wound healing, particularly by promoting migration of fibroblasts, keratinocytes, and endothelial cells. REG‐HAgels improve not only rate, but quality of wound healing with higher collagen deposition and more microvascular formation while being nontoxic. The peptide‐grafted HA hydrogel system can be considered as a promising new wound dressing formulation strategy for the treatment of different types of wounds with combinations of various natural and synthetic WHPs.
All‐Inorganic Perovskite Quantum Dot‐Monolayer MoS2 Mixed‐Dimensional van der Waals Heterostructure for Ultrasensitive Photodetector
Authors: Wu Hualin , Si Haonan , Zhang Zihan , Kang Zhuo , Wu Pingwei , Zhou Lixin , Zhang Suicai , Zhang Zheng , Liao Qingliang , Zhang Yue 
Published: September 2018

Abstract2D transition metal dichalcogenide (2D‐TMD) materials and their van der Waals heterostructures (vdWHs) have inspired worldwide efforts in the fields of electronics and optoelectronics. However, photodetectors based on 2D/2D vdWHs suffer from performance limitations due to the weak optical absorption of their atomically thin nature. In this work, taking advantage of an excellent light absorption coefficient, low‐temperature solution‐processability, and long charge carrier diffusion length, all‐inorganic halides perovskite CsPbI3−xBrx quantum dots are integrated with monolayer MoS2 for high‐performance and low‐cost photodetectors. A favorable energy band alignment facilitating interfacial photocarrier separation and efficient carrier injection into the MoS2 layer inside the 0D–2D mixed‐dimensional vdWHs are confirmed by a series of optical characterizations. Owing to the synergistic effect of the photogating mechanism and the modulation of Schottky barriers, the corresponding phototransistor exhibits a high photoresponsivity of 7.7 × 104 A W−1, a specific detectivity of ≈5.6 × 1011 Jones, and an external quantum efficiency exceeding 107%. The demonstration of such 0D–2D mixed‐dimensional heterostructures proposed here would open up a wide realm of opportunities for designing low‐cost, flexible transparent, and high‐performance optoelectronics.
Toward Programmable Materials for Wearable Electronics: Electrical Welding Turns Sensors into Conductors
Authors: Chellattoan Ragesh , Lube Vinicius , Lubineau Gilles 
Published: September 2018

AbstractStretchable electrical conductors and stretchable strain sensors are two key components in applications such as soft robotics, artificial soft skins, and wearable electronics. Very different approaches are usually implemented to design either conductors or sensors. Here, transformation of an electrically conductive material from a sensor to a conductor using electrical welding (e‐welding) is proposed. This method is demonstrated in the case of a thermoplastic polymer sponge decorated with silver nanowires. The sensor‐like behavior of the sponge is programmed by e‐welding into conductor‐like behavior, i.e., suppressing the gauge factor by 86%, without varying the density of the silver nanowires. An application of e‐welding in the fabrication of a sensor‐conductor hybrid material that may be applied as soft artificial skin in robotics is demonstrated.
Enhancing Squeezing and Nonclassicality of Light in Atom–Optomechanical Systems
Authors: Guo Yanqiang , Guo Xiaomin , Li Pu , Shen Heng , Zhang Jing , Zhang Tiancai 
Published: September 2018

AbstractQuadrature squeezing of light is investigated in a hybrid atom–optomechanical system comprising a cloud of two‐level atoms and a movable mirror mediated by a single‐mode cavity field. When the system is at high temperatures with quadrature fluctuations of light much above the standard quantum limit (SQL), excitation counting on the collective atomic state can effectively reduce the light noise close to the SQL. When the system is at low temperatures, considerable squeezing of light below the SQL is found at steady state. The squeezing is enhanced by simply increasing the atom–light coupling strength with the laser power optimized close to the unstable regime, and further noise reduction is achieved by decreasing the various losses in the system. The presence of atoms and excitation counting on the atoms lessen the limitation of thermal noise, and the squeezing can be achieved at an environment temperature of the order K. The nonclassicality of the light, embodied by the negative distributions of the Wigner function, is also studied by making non‐Gaussian measurements on the atoms. It is shown that with feasible parameters, excitation counting on the atoms is effective in inducing strongly optical nonclassicality.
Design of a Multicompartment Hydrogel that Facilitates Time‐Resolved Delivery of Combination Therapy and Synergized Killing of Glioblastoma
Authors: Majumder Poulami , Baxa Ulrich , Walsh Scott T. R. , Schneider Joel P. 
Published: September 2018

AbstractThere is significant current interest in identifying new combination therapies that synergize to treat disease, and it is becoming increasingly clear that the temporal resolution of their administration greatly impacts efficacy. To facilitate effective delivery, a multicompartment hydrogel material was developed that is composed of spherical vesicles interlaced within a self‐assembled peptide‐based network of physically crosslinked fibrils that allows time‐resolved independent co‐delivery of small molecules. This material architecture effectively delivers the EGFR kinase inhibitor Erlotinib (ERL) and Doxorubicin (DOX, DNA intercalator) in an ERL→DOX sequential manner to synergistically kill glioblastoma, the most aggressive form of brain cancer.
Intercalation‐enhanced “Click” Crosslinking of DNA
Authors: Tera Masayuki , Harati Taji Zahra , Luedtke Nathan W. 
Published: September 2018

AbstractDNA–DNA cross‐linking agents constitute an important family of chemotherapeutics that non‐specifically react with endogenous nucleophiles and therefore exhibit undesirable side effects. Here we report a cationic Sondheimer diyne derivative “DiMOC” that exhibits weak, reversible intercalation into duplex DNA (Kd=15 μm) where it undergoes tandem strain‐promoted cross‐linking of azide‐containing DNA to give DNA‐DNA interstrand crosslinks (ICLs) with an exceptionally high apparent rate constant kapp=2.1×105 m−1 s−1. This represents a 21 000‐fold rate enhancement as compared the reaction between DIMOC and 5‐(azidomethyl)‐2′‐deoxyuridine (AmdU) nucleoside. As single agents, 5′‐bispivaloyloxymethyl (POM)‐AmdU and DiMOC exhibited low cytotoxicity, but highly toxic DNA‐DNA ICLs were generated by metabolic incorporation of AmdU groups into cellular DNA, followed by treatment of the cells with DiMOC. These results provide the first examples of intercalation‐enhanced bioorthogonal chemical reactions on DNA, and furthermore, the first strain‐promoted double click (SPDC) reactions inside of living cells.
Biomimetic Synthesis of (+)‐Aspergillin PZ
Authors: Reyes Julius R. , Winter Nils , Spessert Lukas , Trauner Dirk 
Published: September 2018

AbstractThe cytochalasans are a large family of polyketide natural products with potent bioactivities. Amongst them, the aspochalasins show particularly intricate and fascinating structures. To gain insight into their structural diversity and innate reactivity, we have developed a rapid synthesis of aspochalasin D, the central member of the family. It proceeded in 13 steps starting from divinyl carbinol and utilized a high pressure Diels–Alder reaction that features high regio‐ and stereoselectivity. So far, our work has culminated in a biomimetic synthesis of aspergillin PZ, an intricate pentacyclic aspochalasan.
Modulating Self‐Assembly of DNA Crystals with Rationally Designed Agents
Authors: Zhao Jiemin , Zhao Yue , Li Zhe , Wang Yong , Sha Ruojie , Seeman Nadrian C. , Mao Chengde 
Published: September 2018

AbstractThis manuscript reports a strategy for controlling the crystallization kinetics and improving the quality of engineered self‐assembled 3D DNA crystals. Growing large, high‐quality biomacromolecule crystals is critically important for determining the 3D structures of biomacromolecules. It often presents a great challenge to structural biologists. Herein, we introduce a rationally designed agent to modulate the crystallization process. Under such conditions, fewer, but larger, crystals that yield diffraction patterns of modestly higher resolution are produced compared with the crystals from conditions without the modulating agent. We attribute the improvement to a smaller number of nuclei and slow growth rate of crystallization. This strategy is expected to be generally applicable for crystallization of other biomacromolecules.
Characterizing the degradation behavior of calcium alginate fibers wound dressings fabricated by needle‐punching process
Authors: Gao Yingjun , Jin Xiangyu 
Published: September 2018

ABSTRACTCalcium alginate fibers (CAFs) needle‐punched nonwovens are natural polysaccharide biological dressings. Wound exudates cause salt degradation of CA macromolecules. Herein, degradation process, degradation mechanism, and performance variations of degraded dressings were investigated. The functional group structures changed slightly, while the aggregation structure degraded remarkably. CAF turned into composite containing fiber and sodium alginate (SA) gels, finally degraded to SA gels. The initial degraded dressings maintained stable three‐dimensional (3D) interconnected porous structure. As the degradation and re‐entanglement of CAFs, the dressings changed from volatile composite constituted by degraded CAFs and SA gels to steady foam‐like structure bonded by SA gels with independent pores. Degradation caused significant changes in the interaction between CAFs, altering the stretching and compressing processes of the dressings. SA gels and CAFs formed a stable 3D structure with certain mechanical properties. The bonded SA gels improved the absorption, diffusion, and storage of the wound exudates in the degraded dressings. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46670.