bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D MR Elastography of Hepatocellular Carcinomas as a Potential Biomarker for Predicting Tumor Recurrence
Authors: Wang Jin , Shan Qungang , Liu Yong , Yang Hao , Kuang Sichi , He Bingjun , Zhang Yao , Chen Jingbiao , Zhang Tianhui , Glaser Kevin J. , Zhu Cairong , Chen Jun , Yin Meng , Venkatesh Sudhakar K. , Ehman Richard L. 
Published: September 2018

BackgroundPreoperative prediction of tumor recurrence is important in the management of patients with hepatocellular carcinoma (HCC).PurposeTo investigate whether tumor stiffness derived by magnetic resonance elastography (MRE) could predict early recurrence of HCC after hepatic resection.Study TypeRetrospective.PopulationIn all, 99 patients with pathologically confirmed HCCs after surgical resection.Field Strength/Sequence3.0T; preoperative MRE with 60‐Hz mechanical vibrations using an active acoustic driver.AssessmentRegions of interest (ROIs) were manually drawn in the tumors to measure mean tumor stiffness. Surgical specimens were reviewed for histological grade, capsule, vascular invasion, and surgical margins. The early recurrence of HCC was defined as that occurring within 2 years after resection.Statistical TestsCox proportional hazard models were used to evaluate risk factors associated with the time to early recurrence.ResultsHCCs with recurrence had higher tumor stiffness, higher rate of advanced T stage, vascular invasion, lower rate of capsule formation, larger tumor size, higher aspartate aminotransferase (AST), and hepatitis B virus (HBV)‐DNA level and aspartate aminotransferase / alanine aminotransferase ratio (P = 0.031, 0.007, 0.01, <0.001, 0.015, 0.034, 0.01, and 0.014, respectively) than HCCs without recurrence. Vascular invasion (hazard ratio [HR] = 2.922; 95% confidence interval [CI]: [1.079, 7.914], P = 0.035) and mean tumor stiffness (HR = 1.163; 95% CI: [1.055, 1.282], P = 0.002) were risk factors associated with early recurrence. Each 1‐kPa increase in tumor stiffness was associated with a 16.3% increase in the risk for tumor recurrence.Data ConclusionThe mean stiffness of HCCs may be a useful, noninvasive, quantitative biomarker for the prediction of early HCC recurrence after hepatic resection.Level of Evidence: 4Technical Efficacy: Stage 5J. Magn. Reson. Imaging 2019;49:719–730.
Radiomics Nomogram Building From Multiparametric MRI to Predict Grade in Patients With Glioma: A Cohort Study
Authors: Wang Qiuyu , Li Qingneng , Mi Rui , Ye Hai , Zhang Heye , Chen Baodong , Li Ye , Huang Guodong , Xia Jun 
Published: September 2018

BackgroundAccurate classification of gliomas is crucial for prescribing therapy and assessing the prognosis of patients.PurposeTo develop a radiomics nomogram using multiparametric MRI for predicting glioma grading.Study TypeRetrospective.PopulationThis study involved 85 patients (training cohort: n = 56; validation cohort: n = 29) with pathologically confirmed gliomas.Field Strength/Sequence1.5T MR, containing contrast‐enhanced T1‐weighted (CET1WI), axial T2‐weighted (T2WI), and apparent diffusion coefficient (ADC) sequences.AssessmentA region of interest of the tumor was delineated. A total of 652 radiomics features were extracted and were reduced using least absolute shrinkage and selection operator regression.Statistical TestingRadiomic signature, participant's age, and gender were analyzed as potential predictors to perform logistic regression analysis and develop a prediction model of glioma grading, and a radiomics nomogram was used to represent this model. The performance of the nomogram was assessed in terms of discrimination, calibration, and clinical value in glioma grading.ResultsThe radiomic signature was significantly associated with glioma grade (P < 0.001) in both the training and validation cohorts. The performance of the radiomics nomogram derived from three MRI sequences (with C‐index of 0.971 and 0.961 in the training and validation cohorts, respectively) was improved compared to those based on either CET1WI, T2WI, or ADC alone in glioma grading (with C‐index of 0.914, 0.714, 0.842 in the training cohort, and 0.941, 0.500, 0.730 in the validation cohort). The nomogram derived from three sequences showed good calibration: the calibration curve showed good agreement between the estimated and the actual probability. The decision curve demonstrated that combining three sequences had more favorable clinical predictive value than single sequence imaging.Data ConclusionWe created and assessed a multiparametric MRI‐based radiomics nomogram that may help clinicians classify gliomas more accurately.Level of Evidence: 4Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2019;49:825–833.
Measurements of Diffusion and Perfusion in Vertebral Bone Marrow Using Intravoxel Incoherent Motion (IVIM) With Multishot, Readout‐Segmented (RESOLVE) Echo‐Planar Imaging
Authors: Lasbleiz Jérémy , Le Ster Caroline , Guillin Raphaël , Saint‐Jalmes Hervé , Gambarota Giulio 
Published: September 2018

BackgroundA limited number of studies have used the intravoxel incoherent motion (IVIM) approach on bone marrow. In none of the previous studies were the effects of fat suppression on the IVIM parameters investigated.PurposeTo measure the water diffusion coefficient and the perfusion fraction in vertebral bone marrow using IVIM with multishot, readout‐segmented (RESOLVE) echo‐planar imaging and to assess the effects of different fat suppression techniques on the measurement of the IVIM parameters.Study TypeProspective.Population/SubjectsSix healthy volunteers (24.2 ± 4.3 years).Field Strength/Sequence1.5T, RESOLVE.AssessmentFour experiments were performed: 1) RESOLVE imaging without fat suppression, 2) with fat saturation (FS), 3) with spectral attenuated inversion recovery (SPAIR), and 4) with short‐tau inversion recovery (STIR). The water diffusion coefficient D, pseudo‐diffusion coefficient D*, and the perfusion fraction f were assessed in the vertebral bodies of the lumbar vertebrae.Statistical TestsOne‐way repeated‐measures analysis of variance (ANOVA) followed by Bonferroni's multiple comparison test.ResultsThe RESOLVE IVIM protocol allowed for measurement of D, D*, and f in all volunteers. The signal of lipid protons affected the quantification of the IVIM diffusion coefficient: D = 0.24 ± 0.10 (×10−3 mm2/s), no FS; D = 0.43 ± 0.07 (×10−3 mm2/s), FS; D = 0.42 ± 0.07 (×10−3 mm2/s), SPAIR; D = 0.35 ± 0.10 (×10−3 mm2/s), STIR; and IVIM perfusion fraction f = 7.5 ± 1.9% no FS, f = 14.5 ± 5.4%, FS; f = 12.5 ± 2.6%, SPAIR; f = 18.1 ± 6.1%, STIR. No significant effect (P = 0.36) was found on the quantification of D*.Data ConclusionAn IVIM‐MRI protocol using the RESOLVE sequence was implemented for measurements of vertebral bone marrow diffusion and the perfusion. The comparison between the protocols with and without fat suppression indicates that the lipid signal results in an underestimation of both D and f.Level of Evidence:Technical Efficacy Stage: 1J. Magn. Reson. Imaging 2019;49:768–776.
Emerging role of MRI in radiation therapy
Authors: Chandarana Hersh , Wang Hesheng , Tijssen R.H.N. , Das Indra J. 
Published: September 2018

Advances in multimodality imaging, providing accurate information of the irradiated target volume and the adjacent critical structures or organs at risk (OAR), has made significant improvements in delivery of the external beam radiation dose. Radiation therapy conventionally has used computed tomography (CT) imaging for treatment planning and dose delivery. However, magnetic resonance imaging (MRI) provides unique advantages: added contrast information that can improve segmentation of the areas of interest, motion information that can help to better target and deliver radiation therapy, and posttreatment outcome analysis to better understand the biologic effect of radiation. To take advantage of these and other potential advantages of MRI in radiation therapy, radiologists and MRI physicists will need to understand the current radiation therapy workflow and speak the same language as our radiation therapy colleagues. This review article highlights the emerging role of MRI in radiation dose planning and delivery, but more so for MR‐only treatment planning and delivery. Some of the areas of interest and challenges in implementing MRI in radiation therapy workflow are also briefly discussed.Level of Evidence: 5Technical Efficacy: Stage 5J. Magn. Reson. Imaging 2018;48:1468–1478
Abbreviated MRI of the Breast: Does It Provide Value?
Authors: Leithner Doris , Moy Linda , Morris Elizabeth A , Marino Maria A , Helbich Thomas H , Pinker Katja 
Published: September 2018

MRI of the breast is the most sensitive test for breast cancer detection and outperforms conventional imaging with mammography, digital breast tomosynthesis, or ultrasound. However, the long scan time and relatively high costs limit its widespread use. Hence, it is currently only routinely implemented in the screening of women at an increased risk of breast cancer. To overcome these limitations, abbreviated dynamic contrast‐enhanced (DCE)‐MRI protocols have been introduced that substantially shorten image acquisition and interpretation time while maintaining a high diagnostic accuracy. Efforts to develop abbreviated MRI protocols reflect the increasing scrutiny of the disproportionate contribution of radiology to the rising overall healthcare expenditures. Healthcare policy makers are now focusing on curbing the use of advanced imaging examinations such as MRI while continuing to promote the quality and appropriateness of imaging. An important cornerstone of value‐based healthcare defines value as the patient's outcome over costs. Therefore, the concept of a fast, abbreviated MRI exam is very appealing, given its high diagnostic accuracy coupled with the possibility of a marked reduction in the cost of an MRI examination. Given recent concerns about gadolinium‐based contrast agents, unenhanced MRI techniques such as diffusion‐weighted imaging (DWI) are also being investigated for breast cancer diagnosis. Although further larger prospective studies, standardized imaging protocol, and reproducibility studies are necessary, initial results with abbreviated MRI protocols suggest that it seems feasible to offer screening breast DCE‐MRI to a broader population. This article aims to give an overview of abbreviated and fast breast MRI protocols, their utility for breast cancer detection, and their emerging role in the new value‐based healthcare paradigm that has replaced the fee‐for‐service model.Level of Evidence: 1Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2019;49:e85–e100.
Postharvest metabolomic changes in Pyrus ussuriensis Maxim. wild accession ‘Zaoshu Shanli’
Authors: Xu Jiayu , Zhang Ying , Qi Dan , Huo Hongliang , Dong Xingguang , Tian Luming , Zhang Xiaoshuang , Liu Chao , Cao Yufen 
Published: September 2018

AbstractThere are strong economic drivers for understanding the process of fruit post‐harvest softening. In this study, liquid chromatography with electrospray ionization tandem mass spectrometry was used to analyze metabolite changes in ‘Zaoshu Shanli’ fruit after different storage periods; this wild accession of Pyrus ussuriensis presents good fruit quality and relatively low flesh firmness after fruit storage. The lipid metabolites in ‘Zaoshu Shanli’ fruit were significantly higher at 18 days of storage compared with those at 0 days of storage, and glycerophospholipid metabolism was different metabolic pathway. It was therefore speculated that lipid metabolism play an important role in pear fruit post‐harvest processes and softening. Furthermore, the abscisic acid and trans‐zeatin contents in ‘Zaoshu Shanli’ fruit at 18 days of storage were significantly greater than those at 0 days of storage. Therefore, it was speculated that the abovementioned hormones play an important role in pear fruit post‐harvest softening. Together, these results provide fundamental insight into the reasonable control of pear fruit post‐harvest softening and lay a solid foundation for additional research.
Sample preparation for the analysis of fire debris – Past and present
Authors: Kerr Tanya J. 
Published: September 2018

AbstractIdentification of ignitable liquids from fire debris is such a major part of an arson investigation that much time and effort has gone into advancing sample preparation techniques to capture complicated and unexpected hydrocarbon compounds. Advancements in sample preparation have been made in order to account for biodegradation of commonly used accelerants, rarely encountered compounds, such as vegetable oils, biodiesel, and alcohols. Improvements have also been made to manage interference from the sample matrix, particularly with regards to new materials. This paper is a review of the sample preparation techniques that are foundational to fire debris analysis as well as recent advances. Also explored are modifications to the traditional sample preparation methods to accommodate the analysis of environmental samples (soil and water), and the presence of vegetable oils and biofuels on the fire scene.
A chromatographic study on the retention behavior of the amylose tris(3‐chloro‐5‐methylphenylcarbamate) chiral stationary phase under aqueous conditions
Authors: Cirilli Roberto , Carradori Simone , Casulli Adriano , Pierini Marco 
Published: September 2018

AbstractIn this study, the retention properties of the immobilized polysaccharide‐derived Chiralpak IG‐3 chiral stationary phase under aqueous‐organic conditions were investigated. A systematic evaluation of the retention factors of the enantiomers of the chiral sulfoxide oxfendazole, endowed with anthelmintic activity and selected as test compound, was carried out changing progressively the water content in hydro‐organic eluents containing methanol, ethanol or acetonitrile. From the results obtained with acetonitrile/water mobile phases and the associated retention plots, clear U‐shape retention dependencies, indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed‐phase modes, were highlighted. A U‐turn point of retention mechanism was recorded in correspondence of the acetonitrile/water 100:40 v/v mobile phase. Retention was significantly affected by small percentages of trifluoroacetic acid or diethylamine additives incorporated in the mobile phase. It is worth emphasizing that the basic additive was more effective in reducing retention in the reversed‐phase region, while the action of acid additive was more pronounced in the hydrophilic interaction liquid chromatography region. Finally, either in the transition from hydrophilic interaction liquid chromatography to reversed‐phase conditions or after additive addition, the enantioselectivity did not vary significantly.
Zirconium(IV)‐based metal–organic frameworks (UiO‐67) as solid‐phase extraction adsorbents for extraction of phenoxyacetic acid herbicides from vegetables
Authors: Duo Huixiao , Wang Yuhuan , Wang Licheng , Lu Xiaofeng , Liang Xiaojing 
Published: September 2018

AbstractA zirconium(IV)‐based metal organic framework, composed of 4,4′‐biphenyldicarboxylic acid ligands and Zr6O4(OH)4 clusters, was successfully fabricated. Characterizations were performed on fourier transform infrared spectroscopy, scanning electron microscopy, X‐ray diffraction, Brunauer‐Emmett‐Teller, and thermogravimetric analysis, which confirmed that it possessed large specific surface area, high pore volume, and strong acid resistant stability. Furthermore, the prepared material containing biphenyl skeleton and a large number of Zr‐O bonds, can grasp acid herbicides especially phenoxyacetic acid herbicides with aromatic structures through π‐π interaction, hydrophobic interaction and Zr‐O‐H+ bonds. Based on these advantages, a method was developed for the determination of four phenoxyacetic acid herbicides from vegetable samples. Under the optimal conditions, wide linearities from 0.3 to 250 μg/L and low limits of detection from 0.1 to 0.5 μg/L were obtained. The intra‐ and interday relative standard deviations were 1.56‐3.92 and 5.01‐7.65%, respectively. The proposed method was applied to analyze phenoxyacetic acid herbicides residues in the tomato, cucumber, and white gourd samples. The satisfactory recoveries (86.12–103.44%) for the spiked samples in vegetable samples were achieved which demonstrated the method was an efficient pretreatment procedure and has a potential application for the trace determination of phenoxyacetic acids from a complex matrix.
Postoperative revisits and readmissions after facelift surgery
Authors: Lee Linda N. , Quatela Olivia , Bhattacharyya Neil 
Published: September 2018

Objectives/HypothesisTo determine 30‐day rates and reasons for revisit and readmission after rhytidectomy surgery.Study DesignCross‐sectional analysis.MethodsCross‐sectional analysis was performed of multistate ambulatory surgery and hospital databases. Ambulatory rhytidectomy cases were extracted from State Ambulatory Surgery Databases for New York, Florida, Iowa, and California for 2010 and 2011. Cases were linked to State Emergency Department and Inpatient Databases for visits occurring 1 to 30 days postoperatively.ResultsA total of 6,089 rhytidectomy cases were extracted (87.9% female). The mean age was 61.1 years, and the most common age group was 61 to 70 years (40.2%), followed by 51 to 60 years (33.2%), and 71 to 80 years (12.0%). Overall, 3.6% of patients had a revisit after surgery (42.7% to an ambulatory surgery center, 42.2% to an emergency department, and 15.1% to inpatient admission). The most common primary diagnoses at the time of the revisit were hematoma (17.0%), fever/nausea/diarrhea (4.1%), and urinary tract infection (4.1%).ConclusionsRhytidectomy is performed to treat facial aging, and can provide surgical outcomes which may not be achievable with nonsurgical alternatives. The 30‐day revisit and readmission rate for this procedure in a large multistate cohort has not previously been reported. The revisit rate is low after rhytidectomy, and the most common reason for revisit is hematoma. These data provide important insight to optimize perioperative management and decrease postoperative revisits. This study does not capture return visits to the physician's office; however, postoperative issues that require presentation to outside facilities are important to distinguish from those managed in the practitioner's office, because they may incur additional, unplanned cost to both the patient and the healthcare system.Level of EvidenceNA Laryngoscope, 128:2714–2717, 2018
Noma surgery
Authors: Shaye David A. , Winters Ryan , Rabbels Jens , Adentunji Adenyiyi Seminyu , Magee Aidan , Vo Daniel 
Published: September 2018

ObjectiveNoma is a devastating and destructive disease of the face for which there is a dearth of information regarding surgical options. Herein, we describe the facial deformities and patient characteristics in a patient population affected by noma and the surgical approaches used in treatment.MethodsRetrospective case series of a Doctors Without Borders (Médecins Sans Frontières) intervention at Sokoto Children's Noma Hospital in northern Nigeria, the highest‐volume noma hospital in the world.ResultsTwenty‐two procedures were performed on 18 patients with noma, 44% of whom were children. The majority of patients (n = 10, 55.5%) were made aware of surgical care through a Doctors Without Borders outreach program. Patients' reasons for seeking care included functional (61.1%, n = 11), appearance (61.1%, n = 11), and social stigma (66.7%, n = 12). The majority (83.3%, n = 15) had lip involvement. Four patients (22.2%) underwent staged flap procedures including prelamination, flap delay, or pedicle division. The mean duration of surgical procedure was 87 minutes (range 5–306 minutes). The minor complication rate was 16%. There were no major complications or deaths.ConclusionNoma is a mutilating disease of the face that occurs in settings of extreme malnutrition. A total of 55.5% of noma patients were made aware of surgical care through outreach programs. The majority of noma patients seek care to improve function (61.1%) and appearance (61.1%), and to address social stigma (66.7%). A total of 83.3% of noma patients had lip involvement. Facial reconstructive surgeons must rely on principles of congenital, traumatic, and oncologic deformity repair while focusing on safe, reliable procedures for low‐resource settings.Level of Evidence4 Laryngoscope, 129:96–99, 2019
Enhanced interdisciplinary communication: development of an interactive thyroid nodule/cancer disease map
Authors: Moubayed Sami P. , Machado Rosalie , Tuttle R. Michael , Orloff Lisa A. , Randolph Gregory , Hernandez‐Prera Juan C. , Griffin Martha J. , Urken Mark L. 
Published: September 2018

ObjectivesDeficits related to inadequate clinical communication can result in incorrect diagnoses, inappropriate surgery, incorrect disease stratification, pathologic reporting, and/or interpretation. There are currently no validated or defined solutions to disease‐specific communication with regard to thyroid care.MethodsWe propose a solution that could ameliorate problems arising from inadequate disease‐specific communications between physicians through the development of a thyroid disease‐specific database, the Thyroid Care Collaborative.ResultsTo improve the quality of thyroid nodule and cancer care, we have developed an imaging module for enhanced reporting of ultrasound, cytologic, surgical, and pathologic details that are obtained during the workup and treatment of a patient.ConclusionThe main advantages of this disease‐specific, dynamic, three‐dimensional, anatomic disease map are: 1) portability across institutions and disciplines, 2) disease specificity to thyroid nodule and cancer care, and 3) ability to trigger more detailed evaluation or reconciliation of any change in a patient's status regarding the nature or the extent of a patient's disease. The first and second advantages above have been identified as areas representing opportunities for quality improvement in health informatics research. Laryngoscope, 129:269–274, 2019
Totally implantable active middle ear implant: Hearing and safety results in a large series
Authors: Shohet Jack A. , Gende Deanna M. , Tanita Cheryl S. 
Published: September 2018

ObjectivesTo evaluate hearing performance and safety measures in a large group of totally implantable active middle ear implant (AMEI) wearers.MethodsRetrospective case review of 172 ears (166 patients) with sensorineural hearing loss undergoing implantation of a totally implantable AMEI. Pure‐tone air and bone thresholds, pure‐tone average, speech reception threshold (SRT), and word recognition scores (WRS) at phonetically balanced maximum and at 50 dB (WRS50) were assessed at baseline unaided, with a hearing aid (baseline aided [BLA]), with the implant at activation, and for best implant postoperative measurement. Adverse events were reviewed.ResultsMean length of follow‐up was 35.7 months. Compared to unaided, the implant provided significant gain at all frequencies through 6 kHz. Amount of gain was significantly better with the implant than BLA at 1,500 and 2,000 Hz (P ≤ .001). Implant SRT was also significantly improved compared to BLA (29.9 dB vs. 38.5 dB, P ≤ .001). At a 50‐dB presentation level, WRS was significantly better with the implant than BLA (65.6% vs. 45.5%, P ≤ .001). Bone conduction thresholds were not affected by the implant. The most common adverse event was taste disturbance, which occurred in 39.1%. In subjects with preimplant tinnitus, 56.1% experienced resolution of their tinnitus. Revision surgery was required in 15.7%, and 4% were ultimately explanted.ConclusionThe implant provided significant hearing benefit compared to unaided and to the subjects' own hearing aids in most test categories, with minimal adverse events. Many subjects experienced complete resolution of their tinnitus after implantation.Level of Evidence4 Laryngoscope, 128:2872–2878, 2018