bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avalição da viabilidade de esporos de Bacillus clausii em simulação do trato gastrointestinal humano
Authors: Delgado Junior Manoel Armando , Marques Vilela Danielle , Cristina da Silva Brabes Kelly 
Published: October 2024

O uso de bactérias probióticas formadoras de esporos como Bacillus spp., tem aumentado devido a capacidade de formar esporos resultando em maior resistência durante os processos de produção, armazenamento e comercialização. O Bacillus clausii está no mercado há mais de 55 anos e é caracterizado pela presença de quatro cepas probióticas (O/C, SIN, N/R e T). Neste estudo o Bacillus clausii, proveniente do produto comercial Enterogermina®, foi obtido em Farmácias e Drogarias do município de Dourados-MS. Para caracterizar Bacillus clausii para uso como probiótico foi realizado a análise de pH 2 e 3, teste de tolerância e hidrolise de sais biliares a 0,3%, teste de tolerância a pepsina e pancreatina, teste de adesão e atividade de hemólise. Nas análises de tolerância ao pH ácido, aos sais biliares, a pepsina e pancreatina, não apresentaram diferenças significativas se comparados com o log de UFC/mL-1 de células iniciais. 67% de se aderir a chapa de aço inox. Apresentou atividade de hidrólise sais biliares e de γ-hemolítica em ágar com sangue. Dessa forma indicando grande potencial probiótico.
المقاربة النصية في سياق سورة المؤمنون
Authors: فضل الدوسري عدنان خالد , جاسم ولاء وليد 
Published: October 2024

سورة المؤمنون، هي السورة الثالثة والعشرون في القرآن الكريم، تتميز بأسلوبها الفريد الذي يجمع بين سرد قصص الأنبياء، والتشريعات، والمواعظ الإيمانية. تبدأ السورة بتحديد صفات المؤمنين الحقيقيين، ثم تنتقل بمرونة إلى قصص الأنبياء مثل نوح، وإبراهيم، وموسى، وعيسى، موضحة وحدة الرسالة السماوية عبر التاريخ. تقدم المقاربة النصية تحليلاً لغويًا لهذه السورة بهدف استكشاف محتواها الغني عن طريق فحص بنيتها اللفظية ، بما في ذلك التشابه في الأصوات، والأفعال، والأسماء، والتراكيب النحوية في السياقات المختلفة، مما يكشف عن دقة التعبير القرآني ومعانيه العميقة.
تعتمد السورة على لغة واضحة عند تناول التشريعات، وتستعمل القصص بفعالية؛ لإيصال المعاني العميقة، وتسهم هذه المقاربة في فهم الروابط بين الآيات وكيفية تكاملها؛ لتشكيل رسالة موحدة، وذلك عن طريق المستويات اللغوية الأربعة: الصوتية، والصرفية، والنحوية (التركيبية)، والدلالية. كما تكشف عن الرموز المستعملة في السورة، مثل الماء الذي يمثل الحياة والنقاء؛ مما يضيف عمقًا إضافيًا لفهم النص القرآني. وتعزز هذه العناصر مجتمعة التأثير الروحي والتشريعي للسورة على القارئ، وتبرز أهمية الرسائل الإيمانية والتوجيهات الأخلاقية التي تقدمها.
Resiliensi Ibu Penderita Postpartum Syndrome di Desa Laut Dendang
Authors: Nafilah Husna , Metia Cut 
Published: October 2024

This study aims to analyze the phenomenon related to the analysis of resilience in mothers with postpartum syndrome in Dusun V Cempaka Laut Dendang. In this study, data were taken from interviews with informants totaling 5 people and had varying levels of education starting from S-1, SMA, and SMK. This research uses qualitative methods with a phenomenological approach, with data collection techniques through observation, interviews, and documentation. The data obtained was then analyzed by data reduction, data display, and determining conclusions. The results showed that the five informants interviewed had experienced Postpartum syndrome that occurred after giving birth. Postpartum syndrome occurs due to the inability to manage emotional control and lack of knowledge when giving birth in the first child phase. The resilience built by mothers in Dusun V Cempaka Laut Dendang are: 1) acceptance of conditions and self-education; 2) self-acceptance and awareness of the natural postpartum process; 3) emotional support from husband; 4) full support from husband and family; and 5) support from husband and in-laws. The results of this study as a reference for information in dealing with postpartumsyndrome that occurs in mothers who have just given birth.
Effectiveness of Experiential Learning Approaches (ELA) in enhancing students’ active participation in physical education
Authors: Buen Ralph Julius , Carcahente Carlito , Chu Paula Danielle , Limbo-Rivera Charis 
Published: October 2024

Background: Active participation in physical education (PE) is essential for students’ development yet remains challenging in many schools. Research Objectives: This study aimed to assess the effectiveness of experiential learning approaches, including role-playing and interactive simulations, in enhancing students’ willingness and ability to actively participate in PE at Gabas Integrated School (GIS). Methods: This study utilised a one-group pretest-posttest design in which 34 Grade 9 GIS students participated. A researcher-made survey questionnaire patterned from the Students’ Participation Survey and the Motivation in Physical Education Survey and a checklist tool were used to gather data. Education experts reviewed the survey questionnaire to ensure content validity and conducted a pilot test. The collected data were analysed using Jeffrey’s Amazing Statistics Program (JASP). Findings/Results: The study revealed that the students’s willingness to participate was initially moderately willing, which increased to extremely willing after the intervention. The student’s ability to participate improved from a participative rating to a highly participative rating after the intervention. The Wilcoxon signed-rank test further revealed significant differences between the students’ willingness and ability to participate before and after the intervention. Conclusion: These findings concluded that an experiential learning approach effectively enhances students’ active participation in terms of their willingness and ability to participate in PE classes. Thus, the Department of Education must encourage teachers to use ELA to transform students from passive spectators to active participants. Physical education teachers must also consider incorporating performance-based learning and real-life scenarios that allow students to apply their skills in meaningful contexts to their physical education teaching.
Классификация гистологических препаратов хряща коленного сустава по степени тяжести гонартроза с помощью глубокого обучения на основе YOLOv8
Authors: А.А. Бромберг 
Published: October 2024

Целью исследования было разработать модель машинного обучения классификации гонартроза по степени тяжести на основании изображений костно-хрящевых образцов, окрашенных Сафранином О+FastGreen (SafO) и гематоксилин-эозином (HE). Материалы и методы. Использована предобученная нейросеть YOLOv8m-cls пакета Ultralytics. Работа выполнена на языке Python 3.9. Машинное обучение проводилось на наборе гистологических данных Исследования хряща коленного сустава. Результаты. Разработаны модели машинного обучения для классификации костно-хрящевых образцов по степени тяжести гонартроза. Достигнуты целевые метрики accuracy_top1 соответственно 95,7% для модели, обученной на HE-окрашенных изображениях и 94,3% – на SafO-окрашенных изображениях. Заключение. YOLOv8 обладает достаточной предиктивной способностью в решении задач патоморфологии. Разработанные модели для классификации гонартроза могут быть применены в клинической практике для автоматизации и ускорения работы патологоанатомов и гистологов. Необходимо дальнейшее повышение качества моделей.
This study aims to classify the histopathological HE- and SafO-stained images of bone-cartilage specimens automatically, using YOLOv8 by severity. Materials and methods. The pre-trained YOLOv8m-cls neural network of the Ultralytics package was used. Python 3.9. was used. Models were trained on a Human Knee Cartilage Histopathology Assessment Dataset. Results. Machine learning models were built to score the severity levels of knee oasteoarthritis using the histopathological images of the bone-cartilage specimens. The accuracy_top1 performance was 95.7% for the model trained on HE-images and 94.3% - on SafO images. Conclusion. YOLOv8 can be used in histopathology with high performance. Models can be used by researchers to automate the histopathology severity scoring of knee osteoarthritis. The dataset upscaling and the model modifying could help to improve the quality of predictions.
Ventricular arrhythmias occurring in myocardial infarction patients with acute ST-segment elevation within the first 24 hours after primary percutaneous coronary intervention and their prognostic value
Authors: Bahan U.R. , Kovalchuk R.A. , Svitlyk H.V. 
Published: October 2024

Reperfusion therapy in myocardial infarction patients with acute ST-segment elevation significantly reduced the frequency of ventricular tachycardia and ventricular fibrillation, however, such arrhythmias still occur in 6-8% of patients, posing a threat to their lives.The aim of the study was to determine the nature of ventricular arrhythmias occurring in myocardial infarction patients with acute ST-segment elevation within the first 24 hours after primary percutaneous coronary intervention, and their prognostic value regarding the development of complications during the inpatient treatment phase. The study involved 82 individuals (mean age: 62,4±10,2 years; male: 69,23 (58,6-78,92)%, female: 30,77 (21,08-41,4)%). Within 24 hours after the infarct-related artery stenting, all patients underwent a 24-hour Holter ECG monitoring. The course of the disease was analyzed based on the presence of risk factors such as hypertension, diabetes mellitus, past COVID-19, and obesity. Ventricular rhythm disturbances were represented mainly by premature contractions. They occurred significantly more frequently in patients with arterial hypertension (883,71 (96,0; 986.0); p=0,02; p=0,03; p=0,02, compared to patients with a history of COVID-19, diabetes, and obesity, respectively) and in those with past COVID-19 (711,3 (125,0; 846,5); p=0,01; p=0,04, compared to indi­viduals with diabetes and obesity, respectively). Isolated premature ventricular complexes, pairs, triplets were recorded, and in individuals with arterial hypertension and past COVID-19 “runs” of ventricular extrasystoles and episodes of nonsustained monomorphic and even polymorphic ventricular tachycardia, such as Torsades de Pointes, (under the condition of combined risk factors) were noted; predominantly in these patients during the hospital phase such сom­plications as ventricular fibrillation and asystole,with sudden cardiac arrest developed. The obtained results is an evidence of electrical myocardial instability and indicate that myocardial infarction patients with acute ST-segment elevation, in addition to myocardial revascularization, require optimization of pharmacological treatment. The use of intravenous beta-blockers as part of complex treatment prevented the occurrence of life-threatening ventricular arrhythmias during the inpatient treatment phase.
Comorbidity in in patients with relapsing-remitting multiple sclerosis
Authors: Somilo O.V. , Makarov S.O. , Kalbus O.I. 
Published: October 2024

Multiple sclerosis is a chronic autoimmune inflammatory disease that affects the brain and spinal cord. The most common form of this disease according to the type of its course is relapsing-remitting multiple sclerosis. Comorbidity in multiple sclerosis is an urgent problem of modern neurology, since it can influence such factors as the time of diagnosis, the rate of disease progression and the rate of patient disability, the number of exacerbations and the patient’s quality of life. The purpose of the work was to study and characterize comorbidity in patients with relapsing multiple sclerosis. To conduct this study 105 patients with a diagnosis of relapsing-remitting multiple sclerosis were enrolled. All patients were assessed using the Multiple Sclerosis Neurological Disability Severity Scale (EDSS). Study participants were divided into two groups – Group 1 and Group 2 – based on EDSS scores. Separately, study participants were divided into groups based on the principle of receiving pain-modifying therapy. In the 1st study group, concomitant diseases were in 57 (78.1%) patients, in the 2nd group – in 100% (p=0.010). In patients who did not receive pain-modifying therapy, 57 (98.3%) of those examined had concomitant diseases, in those who received such treatment – in 32 (68.1%), which was statistically significantly less (p<0.001). In the first place in terms of the frequency of concomitant pathology among all examined patients were diseases of the gastrointestinal tract, which also dominated in the 1st and 2nd observation groups, in the second place – diseases of the urinary system, in the third place – eye diseases, and in the last place, by the frequency of concomitant diseases – cardiovascular diseases. Comorbidity in multiple sclerosis is an extremely relevant problem in modern neurology due to its significant impact on the clinical picture of the disease, its course and the degree of disability of the patient. Digestive system disease is one of the most common comorbid conditions in multiple sclerosis. The number of patients with comorbid conditions is higher among patients with a moderate degree of disability and among patients not taking disease-modifying therapy, but the relationship between the degree of disability, treatment and comorbid conditions requires further study.
Toxicological characterization of the insecticide metofluthrin and assessment of the carcinogenic risk to human health due to its chronic inhalation effect
Authors: Yastrub T.O. , Kravchuk O.P. , Basanets A.V. , Yastrub A.M. , Shabalkov D.O. 
Published: October 2024

The aim of the investigation is the toxicological characterization and analysis of the danger criteria of the insecticide metofluthrin with an assessment of the carcinogenic risk to health caused by chronic inhalation exposure to the substance at the level of the maximum possible concentrations in the air environment of human life. The analysis of scientific reports of the US Environmental Protection Agency (US EPA) and the European Chemicals Agency (ECHA) on the toxicological properties of metofluthrin was carried out. The assessment of the risk of the development of carcinogenic effects due to chronic inhalation exposure to metofluthrin was carried out taking into account the average daily dose of the substance that can enter the human body during the natural life span (LADD) and the carcinogenic potential factor (SF) in accordance with domestic guidelines. Classification of levels of carcinogenic risk was carried out using domestic and international approaches. It was established that the limiting criteria for the danger of metofluthrin are the average lethal concentration in air (LC50 =1080 mg/m³) and the size of the zone of chronic action (Zch=7.46), which characterizes the danger of occurrence of chronic intoxication due to long-term inhalation exposure. According to these indicators, metofluthrin is classified as a dangerous substance (hazard class 2). The key effects of the toxic action of metofluthrin are determined – neurotoxicity, hepatotoxicity and nephrotoxicity. The threshold non-genotoxic oncogenic potential of metofluthrin according to the phenobarbital type was established. Individual carcinogenic risk under different scenarios of chronic inhalation exposure to metofluthrin was calculated. The substance concentration of 3.54 mg/m³ leads to a high level of risk (1.5×10-3), which is considered unacceptable for production conditions and the population. At concentrations of 0.28 mg/m³ and 1.0 mg/m³, the risk is estimated as average and acceptable for production conditions (1.1-4.1×10-4). The risk of exposure to a concentration of 0.14 mg/m³ is classified as low and acceptable for the population (5.7×10-5). Thus, the results obtained in the study indicate that such concentrations of metofluthrin in the air as 0.14 – 0.28 – 1.0 mg/m³ are safe for human health, subject to compliance with medical and sanitary regulations at the stage of production and application of insecticides based on metofluthrin as prescribed.
From triage to treatment
Authors: Picard Christopher , Montgomery Carmel L , Violato Efrem M , Douma Matthew J , Norris Colleen M 
Published: October 2024

Background: The COVID-19 pandemic has had a significant impact on healthcare systems worldwide, leading to changes in presentation types, service utilization, and admission rates to emergency departments (ED). This study examines changes in ED visit patterns and triage misclassifications during the pandemic in Alberta, Canada.
Methods: We conducted a retrospective population-level time-series analysis of all patients who presented to 12 EDs in the Edmonton Alberta Zone between March 3, 2019, and March 3, 2022. Routinely collected electronic health record data were analyzed and with primary categories of reporting including Canadian Triage Acuity Scale (CTAS), age, Canadian Emergency Department Information System (CEDIS) presenting complaint, admission status, triage misclassifications, and time markers for patient care.
Results: 1.24 million cases from 12 hospitals were included. When we compare the patterns of presentation to the pre-pandemic period, we found a relative increase of 12.5% in EMS volumes, a 43.2% relative reduction in the proportion of patients presenting to tertiary EDs, 17.2% relative reduction in the number of patients under the age of 18, and a global increase in acuity with the highest relative increase 19.7% coming from patients in the highest acuity level: CTAS 1. Complaint distributions during these periods demonstrated that mental health, substance use, and environmental complaints experienced 15.5%, 22.4%, and 26.7% relative increases in volume, respectively; pediatric specific complaints experienced a 56.5% relative reduction. By the end of the study period, patients spent an average of 59 minutes longer in the ED compared to the pre-pandemic period. The proportion of patients triaged using Epic increased from 7.8% of all patients triaged in the pre-pandemic period to over 66.1% during the pandemic, and there was a 22.9% and 24.2% relative reduction in high-risk triage misclassifications (22.9%) and pain related triage misclassifications (24.2%) by the end of the period compared to the before the pandemic.
Conclusion: Our study adds to the pandemic-related emergency care knowledge base by describing ED visit trends, changes in presenting complaint categories and time markers for patient care over a big-data pre and post pandemic dataset. Nursing-specific ED quality indicators that have not been previously described over a three-year duration between March 3rd 2019 and March 3rd 2022. are also presented. Our study findings have significant implications for healthcare professionals and policymakers in understanding both the impact of the pandemic on ED care delivery as well as future pandemic and post-pandemic ED operations.
Studi Readmisi Pasien Gagal Jantung Kongestif di RSUD Kota Tangerang
Authors: Rahmawati Danisa Ocha , Nurmalasari Mieke , Hosizah Hosizah , Qomarania Witri Zuama 
Published: October 2024

Gagal jantung kongestif termasuk penyakit yang sering terjadi readmisi di rumah sakit meskipun pengobatan rawat jalan telah diberikan secara optimal. Pasien gagal jantung kongestif mengalami readmisi pada saat tidak patuh terhadap tindak lanjut medis, ketidakpahaman pasien dan keluarga mengenai cara perawatan di rumah yang menyebabkan komplikasi dan terjadinya rawat inap ulang (readmisi). Tujuan penelitian adalah mengetahui faktor – faktor yang mempengaruhi readmisi pada pasien gagal jantung kongestif di RSUD Kota Tangerang. Penelitian ini adalah penelitian kuantitatif dengan desain cross-sectional. Sampel terdiri dari 117 rekam medis menggunakan teknik sampling jenuh. Analisis menggunakan Analisis Regresi Logistik Berganda. Hasil penelitian ini diperoleh bahwa distribusi frekuensi faktor demografi pasien yang paling banyak terjadi readmisi pada pasien berusia < 65 tahun sebanyak 52 responden (83,1%), dan berjenis kelamin perempuan sebanyak 34 responden (53,1%). Faktor lainnya adalah LOS < 4 hari sebanyak 41 responden (64,1%) dengan komorbiditas yang dimiliki pasien gagal jantung kongestif adalah pasien dengan komorbiditas kardiovaskular sebanyak 47 responden (73,4%). Terdapat pengaruh yang signifikan antara Length of Stay (LOS) dan komorbiditas terhadap kejadian readmisi pada pasien gagal jantung kongestif. Pasien dengan dengan Length of Stay (LOS) ≥4 hari berpeluang untuk readmisi sebesar 3,105 kali dibandingkan dengan pasien yang LOS nya <4 hari. Pasien dengan komorbid kardiovaskular berpeluang mengalami readmisi sebesar 4,3 kali dibandingkan pasien gagal jantung kongestif dengan komorbid non kardiovaskular. Kata kunci : Readmisi, Gagal Jantung Kongestif, LOS, Komorbiditas
Pengaruh Perubahan Tutupan Lahan Terhadap Debit Banjir di Kawasan Inti Pusat Pemerintahan (KIPP) Ibu Kota Nusantara
Authors: Dimas Harya Wisanggeni  , Jessica Elisabeth Sitorus  , Kahar Halim Prima Putra  , M. Bagus Adityawan  
Published: October 2024

Pembangunan Ibu Kota Nusantara (IKN) dimulai tahun 2022 melalui Penetapan Undang-Undang Republik Indonesia Nomor 3 Tahun 2022 tentang Ibu Kota Negara , menjadikan Kota Nusantara di Penajam Paser Utara, Kecamatan Sepaku, Provinsi Kalimantan Timur sebagai Ibu Kota Negara (IKN) yang baru untuk menggantikan Daerah Khusus Ibu Kota Jakarta. IKN dibangun dengan konsep Sponge City dengan ide dasar mengubah kota menjadi seperti spons yang mampu menyerap, menyimpan, dan mengelola air hujan secara efektif , sedangkan dalam beberapa tahun kedepan akan terjadi perubahan tata guna lahan pada Dearah Aliran Sungai (DAS) sehingga akan meningkatkan potensi banjir. Studi ini merupakan suatu upaya untuk memprediksi dampak perubahan tutupan lahan yang awalnya Kawasan kehutananan menjadi Kawasan Perkotaan. Lokasi studi berada di Kawasan Inti Pusat Pemerintahan (KIPP) dengan luas 5960 hektar terdiri dari kawasan hunian, perkantoran, pemerintahan, ruang terbuka hijau. KIPP berada di 3 SubDas yaitu SubDas Sanggai, SubDas Trunen, SubDas Sanggai yang memiliki Sungai Utama Sanggai, Trunen, dan Semuntai. Penelitian ini terbagi dalam 3 bagian yaitu pengumpulan data, permodelan hidrologi, dan analisis sensitivitas banjir terhadap perubahan tutupan lahan. Metode perhitungan debit banjir menggunakan Hidrograf Satuan Sintetis SCS CN untuk mendapatkan peningkatan debit dan volume limpasan. Analisis Hidrologi menunjukkan terjadi perubahan nilai Curve Number sebesar 10-15% dalam rentang waktu tahun 2020 dan 2035, serta terjadi peningkatan debit puncak dan volume limpasan pada tahun 2035 sebesar 10% dibandingkan pada tahun 2020.
Agribusiness System and Maize Agriculture Development Strategy in Palolo District Sigi Regency
Authors: Rasyid Sofya A. , Antara Made , Anshary Alam , Effendy  , Hadayani  
Published: October 2024

Maize productivity in Palolo District only reaches 4.8 tons/ha, far below the national average. Suboptimal cultivation techniques, limited access to superior seeds, and the use of fertilizers and pesticides that are not in accordance with the recommendations. Farmers' limited knowledge of modern agricultural practices and lack of access to technology and training also affect production yields. A synergistic agribusiness system ensures integration between the upstream and downstream sectors. The purpose of this study is to analyze the success of the maize agribusiness system and formulate a strategy for the development of the maize agribusiness system. The sampling technique is purposive sampling. The analysis method uses agribusiness index, SWOT analysis and AHP. As a result of the calculation of the agribusiness system index, the value obtained is 11.4 from the maximum value of 17.4 or 65.5%. It shows that the maize agribusiness system is running well, in a good value interval (8.71-17.40). As a result of the SWOT and AHP analysis, there are four main strategies for the development of maize agribusiness: Improving farmers' skills through training and mentoring the latest agricultural technology (weight 0.225), optimizing land use and maximizing production (weight 0.219), increasing maize productivity with active extension and technological innovation (weight 0.137), increasing productivity and availability of facilities through the adoption of sustainable agricultural practices and environmentally friendly technology (weight 0.106).