bluuebunny/crossref_metadata_2025_split huggingface dataset:
A visco-hyperelastic constitutive model of short- and long-term viscous effects on isotropic soft tissues
Authors: Matin Zahra , Moghimi Zand Mahdi , Salmani Tehrani Mehdi , Wendland Brianna Regina , Dargazany Roozbeh 
Published: September 2019

Understanding and modeling the constitutive behavior of soft tissues represents an important challenge with significant relevance in medicine and biology. In this paper, we propose a new visco-hyperelastic model to describe the constitutive behavior of soft tissues as an isotropic and homogeneous material. The model is based on the nonlinear framework of continuum mechanics. A generalized Rivlin strain energy and a short-term viscous strain energy are used to describe the elastic part and time-dependence viscous part, respectively, while a long-term viscous function is derived through an integral framework of the applied stretch. To calibrate the material parameters, a set of self-designed uniaxial compression and relaxation tests are carried out on cylindrical samples of bovine liver. Moreover, the model is also validated against the experimental data of synthetic tissues reported by Khan et al. The good agreement between the predicted results and experimental data establishes the relevance of the proposed model. To investigate the model reliability, we have developed a “user-defined materials” subroutine to implement the constitutive behavior of the liver tissue in ABAQUS. By using the model, we simulate in vitro bovine liver behavior under compression and in relaxation and study the relative effects of the hyperelastic and viscous components on liver biomechanics.
Differential response to targeted acupuncture by gender in patients with gastrointestinal cancer cachexia: secondary analysis of a randomized controlled trial
Authors: Yoon Saunjoo L , Grundmann Oliver , Williams Joseph J , Wu Samuel S , Leeuwenburgh Christiaan , Huo Zhiguang , George Thomas J 
Published: September 2019

Background: Cancer cachexia (CC) is a significant contributor to mortality and morbidity in patients with gastrointestinal (GI) cancer. Treatment options to prevent or halt the progression of CC are limited. Targeted acupuncture (TA) was used in GI patients with CC to evaluate for a potential gender effect. Patients and methods: Participants ( n = 30) were recruited from two outpatient clinics in the northern central part of Florida. All participants were diagnosed with CC and GI cancers. A randomized, single-blind, placebo-controlled clinical trial was used to compare TA to non-targeted acupuncture (NTA) over the course of 8 weeks. Primary endpoints were weight and body composition changes measured by bioelectrical impedance analysis (BIA) and biomarker analysis (tumor necrosis factor (TNF)-α and leptin). Herein, gender differences across and within TA and NTA groups were examined as a secondary analysis. Results: A significant ( p = 0.026) interaction between weight and gender was noted, which manifested in a non-significant increase in the male intervention (MI) group, while TNF-α levels significantly increased by gender ( p = 0.028) and group ( p = 0.006) over the course of the study. All other groups either lost or did not change weight. The extracellular-to-intracellular water (ECW/ICW) ratio was significantly elevated for the TA group ( p = 0.02) and for males ( p = 0.009) at completion of the study. TNF-α and leptin levels were positively correlated within the MI group at the end of the study. Conclusion: A decrease in leptin in the MI group corresponded to higher appetite and weight gain. The elevated ECW/ICW ratio indicates an inflammatory response in the MI group. This gender-specific response may be based on hormone-specific regulation of food intake. Further studies with larger sample sizes are required to support the results.
Mobile Mammography Screening as an Opportunity to Increase Access of Rural Women to Breast Cancer Research Studies
Authors: McElfish Pearl A , Su L Joseph , Lee Jeanette Y , Runnells Gail , Henry-Tillman Ronda , Kadlubar Susan A 
Published: September 2019

Objectives: Rural women are underrepresented in cancer research. We hypothesized that providing access to a research study to rural, medically underserved women who were receiving their breast cancer screening using a mobile mammography unit would increase the representation of rural women in a cancer cohort study. Design: This study is a cross-sectional study using a cohort of women who have been recruited to a breast cancer study in Arkansas. Setting: Recruiters accompanied a mobile mammography unit, the MammoVan, to implement a novel method for reaching and recruiting underrepresented rural Arkansas women into the study. Participants include 5850 women recruited from 2010 through 2012 as part of the Arkansas Rural Community Health (ARCH) study. Results: Participants recruited during their mammography screening on the MammoVan tended to be more rural, less educated, and more likely to be non-Hispanic than those recruited in other venues. A significant difference was not noted for race or age. Conclusion: Collaboration with the MammoVan greatly aided the recruitment of rural participants. These strategies can facilitate the representation of this historically underserved and understudied rural population in future research studies.
Toward universal laws of technology evolution: modeling multi-century advances in mobile direct-fire systems
Authors: Kott Alexander 
Published: September 2019

This paper explores the question of whether a single regularity of technological growth might apply to a broad range of technologies, over a period of multiple centuries. To this end, the paper investigates a collection of diverse weapon systems called here the mobile direct-fire systems. These include widely different families of technologies that span the period of 1300–2015 CE: foot soldiers armed with weapons from bows to assault rifles; horse-mounted soldiers with a variety of weapons; foot artillery and horse artillery; towed antitank guns; self-propelled antitank and assault guns; and tanks. The main contribution of this paper is that, indeed, a single, parsimonious regularity describes the historical growth of this extremely broad collection of systems. Multiple, widely different families of weapon systems—from a bowman to a tank—fall closely on the same curve, a simple function of time. This suggests a general model that unites allometric relations (such as Kleiber’s Law) and exponential growth relations (such as Moore’s Law). To this author’s knowledge, no prior research describes a regularity in the temporal growth of technology that covers such widely different technologies and over such a long period of history. This regularity is suitable for technology forecasting, as this paper illustrates with explorations of two systems that might appear 30 years in the future from this writing: a heavy infantryman and a tank. In both cases, the regularity helped lead to nonobvious conclusions, particularly regarding the power of the weapons of such future systems. Furthermore, this result suggests a possibility—and related research questions—that even broader collections of technology families might evolve historically in accordance with what might be called universal laws of technological evolution.
Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto
Authors: Hachinski Vladimir , Einhäupl Karl , Ganten Detlev , Alladi Suvarna , Brayne Carol , Stephan Blossom C. M. , Sweeney Melanie D. , Zlokovic Berislav , Iturria-Medina Yasser , Iadecola Costantino , Nishimura Nozomi , Schaffer Chris B. , Whitehead Shawn N. , Black Sandra E. , Østergaard Leif , Wardlaw Joanna , Greenberg Steven , Friberg Leif , Norrving Bo , Rowe Brian , Joanette Yves , Hacke Werner , Kuller Lewis , Dichgans Martin , Endres Matthias , Khachaturian Zaven S. 
Published: September 2019

The incidence of stroke and dementia are diverging across the world, rising for those in low-and middle-income countries and falling in those in high-income countries. This suggests that whatever factors cause these trends are potentially modifiable. At the population level, neurological disorders as a group account for the largest proportion of disability-adjusted life years globally (10%). Among neurological disorders, stroke (42%) and dementia (10%) dominate. Stroke and dementia confer risks for each other and share some of the same, largely modifiable, risk and protective factors. In principle, 90% of strokes and 35% of dementias have been estimated to be preventable. Because a stroke doubles the chance of developing dementia and stroke is more common than dementia, more than a third of dementias could be prevented by preventing stroke. Developments at the pathological, pathophysiological, and clinical level also point to new directions. Growing understanding of brain pathophysiology has unveiled the reciprocal interaction of cerebrovascular disease and neurodegeneration identifying new therapeutic targets to include protection of the endothelium, the blood-brain barrier, and other components of the neurovascular unit. In addition, targeting amyloid angiopathy aspects of inflammation and genetic manipulation hold new testable promise. In the meantime, accumulating evidence suggests that whole populations experiencing improved education, and lower vascular risk factor profiles (e.g., reduced prevalence of smoking) and vascular disease, including stroke, have better cognitive function and lower dementia rates. At the individual levels, trials have demonstrated that anticoagulation of atrial fibrillation can reduce the risk of dementia by 48% and that systolic blood pressure lower than 140 mmHg may be better for the brain. Based on these considerations, the World Stroke Organization has issued a proclamation, endorsed by all the major international organizations focused on global brain and cardiovascular health, calling for the joint prevention of stroke and dementia. This article summarizes the evidence for translation into action. © 2019 the Alzheimer’s Association and the World Stroke Organisation. Published by Elsevier Inc. All rights reserved.
Professional Quality of Life in intensive care medicine: The 2018 Faculty of Intensive Care Medicine Workforce survey
Authors: Highfield Julie , Parry-Jones Jack 
Published: September 2019

Background Critical care is widely perceived, both within and outside of the speciality, as unremitting and emotionally burdensome. There is a perception of a higher risk to medical staff of burnout than other specialities. Critical care also has considerable emotional and professional rewards. We sought to examine this balance between emotional reward and stress in UK critical care consultants registered with the Faculty of Intensive Care Medicine. Method We conducted a Wellbeing survey of the Faculty of Intensive Care Medicine consultant membership utilising the Professional Quality of Life (Pro-QOL) survey tool. The survey was conducted as part of the Annual Workforce Census. Results In sum, 799 members completed the Pro-QOL survey, making this one of the largest surveys of physician wellbeing in critical care medicine. Data were analysed in accordance with the Pro-QOL manual. Conclusions The results demonstrate moderate risk for burnout and secondary traumatic stress, but this is balanced by moderate compassion satisfaction. No association was demonstrated between age, sex, or size of critical care unit worked in. Further follow-up of this consultant group is warranted to better understand risk factors for burnout and for future mitigation of these risk factors whilst also enhancing the positive aspects of working as a consultant in critical care medicine.
Cabozantinib for patients with advanced hepatocellular carcinoma: a cost-effectiveness analysis
Authors: Shlomai Amir , Leshno Moshe , Goldstein Daniel A. 
Published: September 2019

Background and aims: The multi-kinase inhibitor sorafenib is a first-line drug for patients with advanced hepatocellular carcinoma (HCC). Treatment options for patients whose disease has progressed on sorafenib are limited. In a recent randomized controlled trial (CELESTIAL trial), patients with advanced HCC who had failed prior systemic therapy had moderate progression-free survival and overall survival advantages when treated with the multi-kinase inhibitor cabozantinib. However, since this treatment is costly and is accompanied by significant adverse events in a large proportion of patients, its cost-effectiveness in these patients should be determined. Methods: We developed a Markov model incorporating health outcomes, measured by life-years and quality-adjusted life-years (QALYs) to evaluate the cost-effectiveness of cabozantinib compared with placebo in patients who have failed prior systemic therapy. Results: Treatment with cabozantinib results in a mean gain of 11.6 weeks of life (0.22 life-years) as compared with placebo. When quality of life was incorporated, treatment with cabozantinib produced a gain of 0.16 QALYs. The total mean incremental cost of cabozantinib was US$76,406 per patient. The incremental cost-effectiveness ratio for cabozantinib compared with best supportive care was US$469,374/QALY using the recommended dose of 60 mg cabozantinib daily. Conclusion: Our results suggest that the use of cabozantinib in patients with advanced HCC who have progressed on prior treatment, results in a modest incremental benefit with high incremental costs, suggesting that it is not cost-effective at conventional willingness to pay thresholds.
Evaluation of the Endo-Uro trainer for semi-rigid ureteroscopy training
Authors: Palaneer Sharanya , Aydin Abdullatif , Janabi Hasaneen Al , Al-Jabir Ahmed , Macchione Nicola , Khan Muhammad Shamim , Dasgupta Prokar , Ahmed Kamran 
Published: September 2019

Background: The aim of this study was to evaluate the validity of evidence of the Endo-Uro Trainer (SAMED, Dresden, Germany) for semi-rigid ureteroscopy. Methods: Novice ( n = 29), intermediate-level ( n = 25), and expert ( n = 24) urological surgeons were recruited to participate in the study. Novices were allocated randomly to Groups A and B, where A performed two set procedures using the already validated Uro-Scopic Trainer (Limbs and Things, Bristol, UK), and Group B used the Endo-Uro trainer. Subsequently they were crossed over to perform the same two procedures using the other model. Intermediate and expert groups performed the same procedure on the Endo-Uro trainer only. Objective Structured Assessment of Technical Skills (OSATS) and the procedural times were collected and analyzed. All participants were invited to complete a final evaluation survey. Results: The evaluation survey revealed a realism rating in all aspects, with a mean Likert rating of 4.04/5. Significant differences were observed in performance time between novices and experts ( p = 0.0014), and between intermediates and experts ( p = 0.0113). OSATS scores differed significantly between all groups ( p < 0.0001). Group B novices showed statistically significant improvement in performance time ( p = 0.0012) and OSATS scores ( p = 0.0439) after the crossover. Significant differences in performance time ( p = 0.0025) between groups A and B were also observed post-crossover. Conclusions: This study demonstrated content validity for the Endo-Uro Trainer model. In addition, the model was shown to be capable of differentiating levels of experience, which contributes to the acceptance of the validity hypothesis. Improvement in performance using the model demonstrates its effectiveness for training.
Adverse events associated with home use of mouthrinses: a systematic review
Authors: Tartaglia Gianluca M. , Tadakamadla Santosh Kumar , Connelly Stephen Thaddeus , Sforza Chiarella , Martín Conchita 
Published: September 2019

Background: Poor oral hygiene is strongly associated with oral and systemic diseases. Alongside mechanical tooth cleaning, the adjunctive use of mouthrinses has been widely advocated. Although research on the efficacy of various mouthrinse formulations is very active, there are a lack of conclusive data regarding their adverse effects. Methods: We undertook a systematic review in accordance wih PRISMA guidelines of electronic databases of clinical trials of any duration with daily home use of mouthwashes, presenting clinical and subjective side effects (PROSPERO registration: CRD42016054037). Results: After evaluating 614 titles and abstracts, 154 studies were selected for full-text analysis; 85 final papers were included. Based on the active ingredient in the test product, nine categories were created: cetyl pyridinium chloride, essential oils, chlorhexidine, triclosan, natural products, diclofenac, fluorides, delmopinol, and miscellaneous active substances. Most of the studies were of short duration (less than 6 months) with a defective ‘methods’ description; the reporting of adverse events often being overlooked. Both local morphological (oral mucosa and dental-crown staining, mucosal lesions) and functional (taste modifications, abnormal oral sensation) alterations were reported. Tooth staining was the most commonly listed adverse event, but it was quantitatively assessed only in a very small number of papers; most studies relied on patient reports. Staining was time associated; the longer the study, the higher its reported incidence and severity. Conclusions: The reduced report of side effects may partly be due to a lack of an objective measure and lack of general guidelines that demand studies report their adverse events. The most frequently reported adverse effect was teeth staining. As in most studies, the effect was associated with trial duration; clinical trials should be of sufficient duration. New investigations meeting the suggested criteria of a minimal duration of 6 months should be planned.
Optimization of ultrasonic-assisted copper ion removal from polluted water by a natural clinoptilolite nanostructure through a central composite design
Authors: Sheydaei Mohsen , Gasemsoltanlu Ali Balanejad , Beiraghi Asadollah 
Published: September 2019

AbstractA natural clinoptilolite nanostructure (CNS) along with ultrasonic irradiation was used to remove Cu2+ ions from polluted water. In the first part of this work, natural clinoptilolite was converted to CNS by ball milling. The natural clinoptilolite and prepared CNS samples were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction, N2 adsorption/desorption and pH at the point of zero charge analyses. The SEM images showed the development of CNS from natural clinoptilolite by ball milling. The N2 adsorption/desorption and FTIR spectroscopy confirmed the greater specific surface area, pore volume and number of surface groups of the CNS compared to the natural clinoptilolite. In addition, the crystalline phase of the CNS was the same as the natural clinoptilolite. In the second part of this work, the ultrasonic-assisted sorption of Cu2+ ions from polluted water by CNS was investigated. These experiments were optimized with response surface methodology based on central composite designs. The effects of initial pH of solution, CNS dosage, sonication time and temperature on Cu2+ ion-removal efficiency were investigated. By using a CNS dosage of 500 mg L−1, an initial pH of 6, a sonication time of 12 min and a sonication temperature of 45°C as optimal conditions, 97% of Cu2+ ions were removed from contaminated water. The initial pH was the most effective variable. Ultrasonic-assisted sorption of Cu2+ was more effective than sorption alone, onto the CNS.
Machine learning for discovering missing or wrong protein function annotations
Authors: Nakano Felipe Kenji , Lietaert Mathias , Vens Celine 
Published: September 2019

Abstract

Background
A massive amount of proteomic data is generated on a daily basis, nonetheless annotating all sequences is costly and often unfeasible. As a countermeasure, machine learning methods have been used to automatically annotate new protein functions. More specifically, many studies have investigated hierarchical multi-label classification (HMC) methods to predict annotations, using the Functional Catalogue (FunCat) or Gene Ontology (GO) label hierarchies. Most of these studies employed benchmark datasets created more than a decade ago, and thus train their models on outdated information. In this work, we provide an updated version of these datasets. By querying recent versions of FunCat and GO yeast annotations, we provide 24 new datasets in total. We compare four HMC methods, providing baseline results for the new datasets. Furthermore, we also evaluate whether the predictive models are able to discover new or wrong annotations, by training them on the old data and evaluating their results against the most recent information.

Results
The results demonstrated that the method based on predictive clustering trees, Clus-Ensemble, proposed in 2008, achieved superior results compared to more recent methods on the standard evaluation task. For the discovery of new knowledge, Clus-Ensemble performed better when discovering new annotations in the FunCat taxonomy, whereas hierarchical multi-label classification with genetic algorithm (HMC-GA), a method based on genetic algorithms, was overall superior when detecting annotations that were removed. In the GO datasets, Clus-Ensemble once again had the upper hand when discovering new annotations, HMC-GA performed better for detecting removed annotations. However, in this evaluation, there were less significant differences among the methods.

Conclusions
The experiments have showed that protein function prediction is a very challenging task which should be further investigated. We believe that the baseline results associated with the updated datasets provided in this work should be considered as guidelines for future studies, nonetheless the old versions of the datasets should not be disregarded since other tasks in machine learning could benefit from them.