bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactive effects of severe drought and grazing on the life history cycle of a bioindicator species
Authors: Fritts Sarah Rebecah , Grisham Blake A. , Cox Robert D. , Boal Clint W. , Haukos David A. , McDaniel Patricia , Hagen Christian A. , Greene Daniel U. 
Published: September 2018

AbstractWe used the lesser prairie‐chicken (Tympanuchus pallidicinctus), an iconic grouse species that exhibits a boom–bust life history strategy, on the Southern High Plains, USA, as a bioindicator of main and interactive effects of severe drought and grazing. This region experienced the worst drought on record in 2011. We surveyed lesser prairie‐chicken leks (i.e., communal breeding grounds) across 12 years that represented 7 years before the 2011 drought (predrought) and 4 years during and following the 2011 drought (postdrought). Grazing was annually managed with the objective of achieving ≤50% utilization of aboveground vegetation biomass. We used lek (n = 49) count data and covariates of weather and managed grazing to: (a) estimate long‐term lesser prairie‐chicken abundance and compare abundance predrought and postdrought; (b) examine the influence of annual and seasonal drought (modified Palmer drought index), temperature, and precipitation on long‐term lesser prairie‐chicken survival and recruitment; and (c) assess and compare the influence of grazing on lesser prairie‐chicken population predrought and postdrought. Lesser prairie‐chicken abundance was nearly seven times greater predrought than postdrought, and population declines were attributed to decreased survival and recruitment. The number of days with temperature >90th percentile had the greatest effect, particularly on recruitment. The population exhibited a substantial bust during 2011 and 2012 without a boom to recover in four postdrought years. Adaptive grazing positively influenced the population predrought, but had no effects postdrought. Results suggest that the severe drought in 2011 may have been beyond the range of environmental conditions to which lesser prairie‐chickens, and likely other species, have adapted. Land management practices, such as grazing, should remain adaptive to ensure potential negative influences to all species are avoided. Increasing habitat quantity and quality by reducing habitat loss and fragmentation likely will increase resiliency of the ecosystem and individual species.
Functional metabolomics approach reveals the reduced biosynthesis of fatty acids and TCA cycle is required for pectinase activity in Bacillus licheniformis
Authors: Guan Yi , Yin Di , Du Xi , Ye Xiuyun 
Published: September 2018

Abstract
Increase of pectinase activity is especially important in fermentation industry. Understanding of the metabolic mechanisms can find metabolic modulation approach to promote high yield of pectinase. Higher activity of pectinase was detected in DY1 than DY2, two strains of Bacillus licheniformis. GC–MS-based metabolomics identified differential metabolome of DY2 compared with DY1, characterizing the increased TCA cycle and biosynthesis of fatty acids. Elevated activity of pyruvate dehydrogenase (PDH), α-ketoglutaric dehydrogenase (KGDH) and succinate dehydrogenase (SDH) showed global elevation of carbon metabolism, which is consistent with the result that lowers glucose in DY2 than DY1. Inhibitors malonate, furfural and triclosan, of PDH, SDH and biosynthesis of fatty acids, promoted pectinase activity, where triclosan increased pectinase activity by 179%. These results indicate that functional metabolomics is an effective approach to understand metabolic mechanisms of fermentation production and provides clues to develop new methods for changing bacterial physiology and production.
The updated Charlson comorbidity index is a useful predictor of mortality in patients with Staphylococcus aureus bacteraemia
Authors: Ternavasio-de la Vega H. G. , Castaño-Romero F. , Ragozzino S. , Sánchez González R. , Vaquero-Herrero M. P. , Siller-Ruiz M. , Spalter-Glicberg G. , Ramírez-Baum C. , Rodríguez-Rodríguez S. , García-Sánchez J. E. , García-García I. , Marcos M. 
Published: September 2018

AbstractThe objective was to compare the performance of the updated Charlson comorbidity index (uCCI) and classical CCI (cCCI) in predicting 30-day mortality in patients with Staphylococcus aureus bacteraemia (SAB). All cases of SAB in patients aged ⩾14 years identified at the Microbiology Unit were included prospectively and followed. Comorbidity was evaluated using the cCCI and uCCI. Relevant variables associated with SAB-related mortality, along with cCCI or uCCI scores, were entered into multivariate logistic regression models. Global model fit, model calibration and predictive validity of each model were evaluated and compared. In total, 257 episodes of SAB in 239 patients were included (mean age 74 years; 65% were male). The mean cCCI and uCCI scores were 3.6 (standard deviation, 2.4) and 2.9 (2.3), respectively; 161 (63%) cases had cCCI score ⩾3 and 89 (35%) cases had uCCI score ⩾4. Sixty-five (25%) patients died within 30 days. The cCCI score was not related to mortality in any model, but uCCI score ⩾4 was an independent factor of 30-day mortality (odds ratio, 1.98; 95% confidence interval, 1.05–3.74). The uCCI is a more up-to-date, refined and parsimonious prognostic mortality score than the cCCI; it may thus serve better than the latter in the identification of patients with SAB with worse prognoses.
The Determination and Application of the Point Spread Function in the Scanning Electron Microscope
Authors: Zotta Matthew D. , Nevins Mandy C. , Hailstone Richard K. , Lifshin Eric 
Published: September 2018

AbstractA method is presented to determine the spatial distribution of electrons in the focused beam of a scanning electron microscope (SEM). Knowledge of the electron distribution is valuable for characterizing and monitoring SEM performance, as well as for modeling and simulation in computational scanning electron microscopy. Specifically, it can be used to characterize astigmatism as well as study the relationship between beam energy, beam current, working distance, and beam shape and size. In addition, knowledge of the distribution of electrons in the beam can be utilized with deconvolution methods to improve the resolution and quality of backscattered, secondary, and transmitted electron images obtained with thermionic, FEG, or Schottky source instruments. The proposed method represents an improvement over previous methods for determining the spatial distribution of electrons in an SEM beam. Several practical applications are presented.
Pakistan Developmental Origins of Health and Disease (DOHaD) Society: addressing the ‘DO’ component of DOHaD
Authors: Mohammed N. , Nuruddin R. , Shoukat Ali A. 
Published: September 2018

AbstractAdverse intrauterine environment could serve as an important stimulus for postnatal altered health status and for increased susceptibility to long-term non-communicable diseases (NCDs). The notion is now recognized as the Developmental Origins of Health and Disease (DOHaD), which was first proposed by Sir David Barker. Since then, several scientific disciplines have strived to measure the magnitude of the early fetal programming and later risk of diseases. Pakistan, with striking figures of morbidity and mortality from NCDs, is currently tackling with double burden of diseases and requires planned efforts to counteract the threat of NCDs. Considering the growing needs and available evidences, Pakistan DOHaD Society was officially instigated in September 2016. The Society aims to explicitly address the association of life in utero with future health and disease and to endorse early screening and interventions to reduce the burden of NCDs, mental health issues and learning disorders along the life course. It has shown significant progress toward investigating the influence of adverse in utero environment such as diabetes, maternal under-nutrition and pre-eclampsia on fetal programming under two major research lines, that is, cardiovascular and cerebrovascular programming. The Society has been successful in disseminating its research findings through several esteemed international scientific conferences. Pakistan DOHaD Society encourages scientific community for collaborative research aimed at improving the quality of life during early childhood, adolescence and adulthood through provision of appropriate pre-pregnancy and antenatal interventions targeted to address at-risk in utero conditions.
Emergence/Subsidence Histories Along the Carnegie and Cocos Ridges and Their Bearing Upon Biological Speciation in the Galápagos
Authors: Orellana‐Rovirosa Felipe , Richards Mark 
Published: September 2018

AbstractUsing plate motion reconstructions for the Nazca, Cocos, and South American plates in relation to the Galápagos hotspot, we find that age‐depth dependence of bathymetry, Galápagos plume dynamic topography, crustal relaxation, and magmatic production permit reasonable estimates for the subsidence of former islands along the Carnegie and Cocos Ridges. Our dynamic topography estimates are partially based upon geodynamic theory (fluid mechanics and elasticity) and also upon detailed bathymetric observations and analysis. For three different target areas over Carnegie Ridge and two over Cocos Ridge, we infer subaerial landmasses over the past ~20 Ma. We provide rough estimates of the surface areas of these paleo‐archipelagos, which were comparable to that of the present‐day Galápagos archipelago. We construct a history of emerged (paleo‐island) topography along the conjugate pair Carnegie‐Cocos hotspot tracks and infer that significant subaerial landscapes existed for at least the past ~20 Ma. The genetic ancestors of endemic faunal species in Galápagos (e.g., marine iguanas) migrated away from South America, genetically diverging from their land counterparts much earlier than the age of the present Galápagos Islands (~3 Ma). At 16.5 Ma, the total emerged landmass on the Carnegie Ridge alone may have been ~2.5 times that of the current Galápagos archipelago. (The conjugate landmass along the Cocos Ridge has been subducted.) We propose that this large landmass, at least one‐fourth the size of Iceland, be called Darwinia in recognition of its importance in the evolution of some Galápagos endemic flora and fauna made famous by Darwin's explorations.
Continuous Vocal Fry Simulated in Laboratory Subjects: A Preliminary Report on Voice Production and Listener Ratings
Authors: Venkatraman Anumitha , Sivasankar M. Preeti 
Published: September 2018

Purpose
Vocal fry is prevalent in everyday speech. However, whether the use of vocal fry is detrimental to voice production is unclear. This preliminary study assessed the effects of using continuous vocal fry on voice production measures and listener ratings.

Method

Ten healthy individuals (equal male and female, mean age = 22.4 years) completed 2 counterbalanced sessions. In each session, participants read in continuous vocal fry or habitual voice quality for 30 min at a comfortable intensity. Continuous vocal fry was simulated. Phonation threshold pressure (PTP
10
and PTP
20
), cepstral peak prominence, and vocal effort ratings were obtained before and after the production of each voice quality. Next, 10 inexperienced listeners (equal male and female, mean age = 24.1 years) used visual analog scales to rate paired samples of continuous vocal fry and habitual voice quality for naturalness, employability, and amount of listener concentration.

Results

PTP
10
and vocal effort ratings increased after 30 min of continuous vocal fry. Inexperienced listeners rated continuous vocal fry more negatively than the habitual voice quality.

Conclusions
Thirty minutes of simulated, continuous vocal fry worsened some voice measures when compared with a habitual voice quality. Samples of continuous vocal fry were rated as significantly less employable, less natural, and requiring greater listener concentration as compared with samples of habitual voice quality. Future studies should include habitual users of vocal fry to investigate speech stimulability and adaptation with cueing to further understand pathogenesis of vocal fry.
Making Applied Linguistics Applicable to Business Practice. Discourse Analysis as a Management Tool
Authors: Darics Erika , Clifton Jonathan 
Published: September 2018

AbstractThis article makes a case for increasing the discursive awareness of practitioners and developing their discourse analytical skills. Although the importance of such an awareness is being increasingly recognized by scholars and practitioners alike, the insights of fine-grained discursive analyses of talk-in-interaction have rarely been seriously considered as resources for accomplishing managerial objectives. Consequently, reflecting on naturally occurring talk as a way of managing remains rare. In this article, we provide an illustration of how the in situ practice of telling stories of organizational change could give change initiators the tools with which to make visible, and thus actionable, the seen but unnoticed underlying assumptions, unshared information, and patterns of collective thinking about change. We close the article with a call for discourse analysis to be taken more seriously in management practice and training.
Composition and the Logic of Location: An Argument for Regionalism
Authors: Gilmore Cody , Leonard Matt 
Published: September 2018

AbstractNed Markosian (2014) has recently defended a new theory of composition, which he calls regionalism: some material objects xx compose something if and only if there is a material object located at the fusion of the locations of xx. Markosian argues that regionalism follows from what he calls the subregion theory of parthood (STP). Korman and Carmichael (2016) agree. We provide countermodels to show that regionalism does not follow from (STP), even together with fourteen potentially implicit background principles. We then show that regionalism does follow from five of those background principles together with (STP) and two additional principles connecting parthood and location, which we call (Overlap) and (Strong Delegation). While the additional principles are not uncontroversial, our conjecture is that many will find them attractive. We conclude by mentioning that (Strong Delegation) fills a previously unnoticed gap in the formal theory of location presented in Parsons (2007).
Whole-plant frost hardiness of mycorrhizal (Hebeloma sp. or Suillus luteus) and non-mycorrhizal Scots pine seedlings
Authors: Korhonen Anna , Lehto Tarja , Heinonen Jaakko , Repo Tapani 
Published: September 2018

Abstract
Ectomycorrhizal trees are common in the cold regions of the world, yet the role of the mycorrhizal symbiosis in plant cold tolerance is poorly known. Moreover, the standard methods for testing plant frost hardiness may not be adequate for roots and mycorrhizas. The aims of this study were to compare the frost hardiness of mycorrhizal and non-mycorrhizal Scots pine (Pinus sylvestris L.) seedlings and to test the use of reverse-flow root hydraulic conductance (Kr) measurement for root frost hardiness determination. Mycorrhizal (Hebeloma sp. or Suillus luteus) and non-mycorrhizal seedlings were grown in controlled-environment chambers for 13 weeks. After this, half of the plants were allotted to a non-hardening treatment (long day and high temperature, same as during the preceding growing season) and the other half to a hardening (short day and low temperature) ‘autumn’ treatment for 4 weeks. The intact seedlings were exposed to whole-plant freezing tests and the needle frost hardiness was measured by relative electrolyte leakage (REL) method. The seedlings were grown for three more weeks for visual damage assessment and Kr measurements using a high-pressure flow meter (HPFM). Mycorrhizas did not affect the frost hardiness of seedlings in either hardening treatment. The effect of the hardening treatment on frost hardiness was shown by REL and visual assessment of the aboveground parts as well as Kr of roots. Non-mycorrhizal plants were larger than mycorrhizal ones while nitrogen and phosphorus contents (per unit dry mass) were similar in all mycorrhiza treatments. In plants with no frost exposure, the non-mycorrhizal treatment had higher Kr. There was no mycorrhizal effect on plant frost hardiness when nutritional effects were excluded. Further studies are needed on the role of mycorrhizas especially in the recovery of growth and nutrient uptake in cold soils in the spring. The HPFM is useful novel method for assessment of root damage.
Quality of Life in Males and Females With Idiopathic Scoliosis
Authors: Diarbakerli Elias , Grauers Anna , Danielsson Aina , Abbott Allan , Gerdhem Paul 
Published: September 2018

Study Design.
Cross-sectional.

Objective.
To describe quality of life in males and females with idiopathic scoliosis.

Summary of Background Data.
Idiopathic scoliosis is a three-dimensional deformity affecting the growing spine. The prevalence of larger curves, requiring treatment, is higher in females.

Methods.
This cross-sectional study comprised 1519 individuals with idiopathic scoliosis (211 males) with a mean (SD) age of 35.3 (14.9) years. They all answered the Scoliosis Research Society 22 revised (SRS-22r) questionnaire and EuroQol 5-dimension-index (EQ-5D). Five hundred twenty eight were surgically treated (78 males), 535 were brace treated (50 males), and 456 were untreated (83 males). The SRS-22r subscore (excluding the satisfaction domain), the SRS-22r domains and the EQ-5D index score were calculated. Subgroup analyses based on treatment and age were performed. Statistical comparisons were performed using analysis of covariance with adjustments for age and treatment. A P-value less than 0.05 was considered as statistical significant.

Results.
The mean (SD) SRS-22r subscore was 4.19 (0.61) in males and 4.05 (0.61) in females (P = 0.010). The males had higher scores on the SRS-22r domains function (4.56 vs. 4.42), pain (4.20 vs. 4.00), and mental health (4.14 vs. 3.92) (all P < 0.05). The mean (SD) EQ-5D index score was 0.85 (0.22) for males and 0.81 (0.21) for females (P = 0.10). There were minor differences when comparing males and females in treatment and age groups, but both treated and untreated groups had reduced quality of life compared with the national norms.

Conclusion.
When compared with females, males with idiopathic scoliosis tend to have slightly higher scores in the scoliosis specific SRS-22r but not in the generic quality of life measurement EQ-5D. Quality of life is overall similar between males and females in treatment and age groups, but reduced in comparison with the general population.

Level of Evidence: 3
Early Maturity as the New Normal: A Century-long Study of Bone Age
Authors: Boeyer Melanie E. , Sherwood Richard J. , Deroche Chelsea B. , Duren Dana L. 
Published: September 2018

Abstract

Background
Epiphyseal fusion (EF) marks the completion of longitudinal bone growth, a critical milestone monitored during treatment of skeletal growth and/or developmental disorders. Recently, a trend toward accelerated skeletal maturation in children has been documented. Because current methods for assessing skeletal maturation include children in their reference populations born as early as the 1930s, the timing of EF events in contemporary patients may differ substantially from those standards.

Questions/purposes
(1) Do children today initiate the process of EF in the hand and wrist earlier than past generations on which maturity standards are based? (2) Do children today complete EF in the hand and wrist earlier than past generations on which maturity standards are based?

Methods
A total of 1292 children (665 males, 627 females) participating in the Fels Longitudinal Study, born between 1915 and 2006, were included in this retrospective, observational study. Each participant had between one and 39 serial left hand-wrist radiographs during childhood obtained specifically for research purposes. Main outcomes were the chronological age at the first sign of EF initiation (EF-I) and the first chronological age when EF was complete (EF-C) in the radius and ulna, and metacarpals and phalanges of the first, third, and fifth rays according to criteria of the Fels method. EF is a reliable metric with an average κ agreement statistic of 0.91. Penalized B-splines were used to model the changes in EF-I and EF-C ages and to identify changes across continuous birth years with major comparisons between children born in 1935 and 1995.

Results
Approximately half of the epiphyses of the hand and wrist examined exhibited earlier EF-I and/or earlier EF-C in children born in 1995 compared with those born in 1935. The age at each milestone (EF-I and EF-C) decreased by as much as 6.7 and 6.8 months in males and 9.8 and 9.7 months in females, respectively. This change occurred gradually over the past century. The more proximal traits (EF of the distal radius, distal ulna, and metacarpals) were more likely to experience a shift in timing, whereas timing of EF in the phalanges remained relatively stable across birth years.

Conclusions
A trend has occurred over the past century in the timing of EF, in both initiation and completion of the process, for many of the bones of the hand and wrist. Earlier EF reflects modern population advances in both skeletal and sexual maturation. Shifts in the timing of EF have the potential to influence treatment strategies for skeletal growth and/or developmental disorders such as scoliosis or leg length inequality, moving treatment windows to earlier ages. Earlier EF-I and EF-C identified in this study signals a need to reevaluate the timing of maturational milestones and current standards for skeletal assessment.

Level of Evidence
Level II, prognostic study.