bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiographic management of percutaneous renal procedure‐related bleeding: A single‐center experience
Authors: Choi Min Jeong , Kim Pyeong Hwa , Shin Ji Hoon , Kim Jong Woo , Gwon Dong Il , Kim Jin Hyoung , Ko Gi‐Young , Yoon Hyun‐Ki , Ohm Joon Young 
Published: December 2018

ObjectivesTo present the radiological and clinical results of transcatheter arterial embolization in patients with active bleeding after percutaneous renal procedures.MethodsA total of 79 consecutive patients who underwent angiography for percutaneous renal procedure‐related bleeding were included in the present retrospective analysis. Patient characteristics, angiographic management and clinical outcomes were analyzed.ResultsOn angiography, bleeding foci were observed in 81.0% of the patients (64/79), all of whom underwent transcatheter arterial embolization. Among the 15 patients (19.0%) with negative angiographic findings, empirical transcatheter arterial embolization was carried out in six patients (40.0%). The technical success rate in 64 patients with positive angiographic findings was 100%, and the clinical success rate in 70 patients who underwent transcatheter arterial embolization was 85.7% (60/70). A total of 14.3% (10/70) of patients with clinical failure underwent repeat transcatheter arterial embolization and all achieved clinical recovery. There were no major complications. There was no statistical difference in estimated glomerular filtration rate values before the percutaneous renal procedure and those measured 7 days after transcatheter arterial embolization (43.4 ± 24.4 to 44.6 ± 25.1 mL/min/1.73 m2; P = 0.189). Clinical failure was not associated with age, sex, type of renal procedures, bleeding tendency, presence of active bleeding on angiography, latency time and embolic agents used (P > 0.05).ConclusionsTranscatheter arterial embolization is a safe and effective method of treating percutaneous renal procedure‐related bleeding without renal function deterioration.
Experiences of self‐stigmatization and parenting in Chinese mothers with severe mental illness
Authors: Chan Sonia Ying Yin , Ho Grace W.K. , Bressington Daniel 
Published: December 2018

AbstractMental health stigma has serious ramifications on people with a severe mental illness (SMI). Stigma damages self‐esteem, recovery outcomes, family relationships, socialization abilities, access to housing, and career prospects. The cultural tendencies of Chinese people have been shown to be associated with particularly high levels of stigmatization. These cultural tenets can result in high levels of self‐stigma due to experiencing shame and a perceived need to keep mental illness a secret. Although there is a lack of existing evidence, it is possible that such experiences present unique challenges to Chinese mothers diagnosed with SMI when they parent their children. Therefore, this qualitative study explored the experiences of parenting and self‐stigmatization of Chinese mothers with SMI. Individual semi‐structured interviews were conducted with 15 mothers who were direct carers of their children aged under 18 and who were receiving community‐based care in Hong Kong. Manual inductive thematic analysis was used to analyse the interview data. Three main themes related to self‐stigmatization emerged from the interviews: (i) distancing and being distanced; (ii) doubting myself; and (iii) struggling for control. The experiences of self‐stigmatization appeared to damage these mothers’ self‐efficacy, which may negatively affect their parenting self‐esteem, tendency to seek professional help, and ability to manage their own mental health. Strategies to improve self‐efficacy, including psychoeducation, and additional childcare support/resources are required for mothers with SMI so they can better manage and balance the demands of motherhood and their mental healthcare needs.
Influenza B associated paediatric acute respiratory infection hospitalization in central vietnam
Authors: Yoshihara Keisuke , Le Minh Nhat , Toizumi Michiko , Nguyen Hien Anh , Vo Hien Minh , Odagiri Takato , Fujisaki Seiichiro , Ariyoshi Koya , Moriuchi Hiroyuki , Hashizume Masahiro , Dang Duc Anh , Yoshida Lay‐Myint 
Published: December 2018

AbstractBackgroundInfluenza B is one of the major etiologies for acute respiratory infections (ARI) among children worldwide; however, its clinical‐epidemiological information is limited. We aimed to investigate the hospitalization incidence and clinical‐epidemiological characteristics of influenza B‐associated paediatric ARIs in central Vietnam.MethodsWe collected clinical‐epidemiological information and nasopharyngeal swabs from ARI children hospitalized at Khanh Hoa General Hospital, Nha Trang, Vietnam from February 2007 through June 2013. Nasopharyngeal samples were screened for 13 respiratory viruses using Multiplex‐PCRs. Influenza B‐confirmed cases were genotyped by Haemagglutinin gene sequencing. We analyzed the clinical‐epidemiological characteristics of influenza B Lineages (Victoria/Yamagata) and WHO Groups.ResultsIn the pre‐A/H1N1pdm09 period, influenza B‐associated ARI hospitalization incidence among children under five was low, ranging between 14.7 and 80.7 per 100 000 population. The incidence increased to between 51.4 and 330 in the post‐A/H1N1pdm09. Influenza B ARI cases were slightly older with milder symptoms. Both Victoria and Yamagata lineages were detected before the A/H1N1pdm09 outbreak; however, Victoria lineage became predominant in 2010‐2013 (84% Victoria vs 16% Yamagata). Victoria and Yamagata lineages did not differ in demographic and clinical characteristics. In Victoria lineage, Group1 ARI cases were clinically more severe compared to Group5, presenting a greater proportion of wheeze, tachypnea, and lower respiratory tract infection.ConclusionsThe current results highlight the increased incidence of influenza B‐related ARI hospitalization among children in central Vietnam in the post‐A/H1N1pdm09 era. Furthermore, the difference in clinical severity between Victoria lineage Group1 and 5 implies the importance of influenza B genetic variation on clinical presentation.
The modulating role of gender and aggression in emotional reactions of nursing students: A cross‐sectional study
Authors: Fino Edita , Di Campli Serena , Patrignani Giulia , Mazzetti Michela 
Published: December 2018

AbstractAimsTo examine whether and to what extent emotion reactions of nursing students are affected by emotional features inherent in nursing care situations, focusing on gender and aggression.BackgroundHow individual characteristics of nurse students interact with emotional demands inherent in nursing practice and modulate the way they are perceived and acted upon may have an impact on quality of patient care.DesignCross‐sectional study, conducted from May to September 2013.MethodsNursing students (N = 157) of the Nursing Degree Course of School of Medicine, Bologna University, completed self‐report questionnaires assessing individual differences (i.e. aggression, personality traits, empathy) and evaluated emotion‐inducing pictures of pleasant, unpleasant and neutral content.ResultsGender and verbal aggression level modulate emotional responses of nursing students: females rated negative picture categories as significantly less pleasant than male students; those with high compared to low verbal aggression levels rated negative stimuli as less arousing and more pleasant. Verbal aggression level is positively related to physical aggression and anger and negatively related to emotional stability and empathy in both males and females.ConclusionHigh verbal aggression scores seem to be associated with attenuated arousal in response to emotional stimuli and decreased aversive reaction towards negative content pictures, indicating a potential facilitation of approach and management of adverse events strictly connected to nursing practice. Nonetheless, aggression can represent a risk factor in nursing practice. Negative implications of verbal aggression are highlighted together with the need for tailoring education programs aimed at enhancing emotion regulation and aggression management skills in nursing context.
Self‐management of health by people with intellectual and developmental disabilities
Authors: Friedman Carli , Rizzolo Mary C. , Spassiani Natasha A. 
Published: December 2018

AbstractBackgroundSelf‐management of health includes people with intellectual and developmental disabilities (IDD) playing a key role in health management in collaborating with healthcare professionals.MethodsThis study analysed data from Personal Outcome Measures® surveys (n = 1,341) to explore self‐management of health. We had the following research questions: Who is most likely to be supported to self‐manage their health? How does being supported to self‐manage impact different areas of health? and How does being supported to self‐manage impact other health‐related organizational supports?ResultsFindings revealed the impact of self‐management of health can be wide‐ranging, regardless of impairment severity. When supported to self‐manage their health, healthcare professionals were more likely to address healthcare issues, and interventions were more likely to be effective.ConclusionsSelf‐management represents a paradigm shift for people with IDD because it transforms people from passive recipients to active directors of their health.
Factors that affect the physical and mental health of caregivers of school‐age children and transitioning young adults with autism spectrum disorder
Authors: Lee Gloria K. , Shivers Carolyn M. 
Published: December 2018

AbstractBackgroundAlthough studies have examined quality of life (QOL) among family caregivers of individuals with autism spectrum disorder (ASD), little is known about potential differences in QOL based on the age of the individual with ASD, particularly in relation to caregivers’ needs, beliefs and coping mechanisms.MethodThis study investigated 132 caregivers of school‐age children and 61 caregivers of transitioning young adults with ASD on measures of caregiving, strain, coping, family needs and QOL.ResultsThe results indicated that there were no significant differences in QOL based on the age of the individuals with ASD, although parents of children reported significantly more caregiving behaviours, with coping, internalized strain and health information needs predicted mental health QOL.DiscussionAge of the individual with ASD was not significantly related to caregivers’ QOL. More research is needed to determine independent predictors of caregiver QOL across the lifespan.
Recognition versus disclosure of finance leases: Evidence from Japan
Authors: Kusano Masaki 
Published: December 2018

AbstractThis study examines whether credit market participants—bond investors and credit rating agencies—treat recognized and disclosed finance leases differently when assessing firms’ credit risk in Japan. I use firms’ credit risk, measured by bond spreads and credit ratings, to investigate the relations between recognized versus disclosed finance lease obligations and firms’ credit risk following the adoption of Statement No. 13, Accounting Standard for Lease Transactions. For a sample of firms issuing new bonds, I find that, unlike recognized finance leases, disclosed finance leases are not associated with bond spreads. Moreover, the associations between recognized versus disclosed finance leases and bond spreads are substantially different. Conversely, recognized and disclosed finance leases are associated with credit ratings and are processed similarly when credit ratings are determined. Taken together, my results suggest that the sophistication of capital market participants influences their credit risk assessments of recognized versus disclosed finance leases.
Utility of ripple mapping for identification of slow conduction channels during ventricular tachycardia ablation in the setting of arrhythmogenic right ventricular cardiomyopathy
Authors: Xie Shuanglun , Kubala Maciej , Liang Jackson J. , Yang Jiandu , Desjardins Benoit , Santangeli Pasquale , van der Geest Rob J. , Schaller Robert , Riley Michael , Supple Gregory , Frankel David S. , Callans David , PAC Erica Zado , Marchlinski Francis , Nazarian Saman 
Published: December 2018

AbstractBackgroundRipple mapping displays every deflection of a bipolar electrogram and enables the visualization of conduction channels (RMCC) within postinfarction ventricular scar to guide ventricular tachycardia (VT) ablation. The utility of RMCC identification for facilitation of VT ablation in the setting of arrhythmogenic right ventricular cardiomyopathy (ARVC) has not been described.ObjectiveWe sought to (a) identify the slow conduction channels in the endocardial/epicardial scar by ripple mapping and (b) retrospectively analyze whether the elimination of RMCC is associated with improved VT‐free survival, in ARVC patients.MethodsHigh‐density right ventricular endocardial and epicardial electrograms were collected using the CARTO 3 system in sinus rhythm or ventricular pacing and reviewed for RMCC. Low‐voltage zones and abnormal myocardium in the epicardium were identified by using standardized late‐gadolinium–enhanced (LGE) magnetic resonance imaging (MRI) signal intensity (SI) z‐scores.ResultsA cohort of 20 ARVC patients that had undergone simultaneous high‐density right ventricular endocardial and epicardial electrogram mapping was identified (age 44 ± 13 years). Epicardial scar, defined as bipolar voltage less than 1.0 mV, occupied 47.6% (interquartile range [IQR], 30.9‐63.7) of the total epicardial surface area and was larger than endocardial scar, defined as bipolar voltage less than 1.5 mV, which occupied 11.2% (IQR, 4.2 ± 17.8) of the endocardium (P < 0.01). A median 1.5 RMCC, defined as continuous corridors of sequential late activation within scar, were identified per patient (IQR, 1‐3), most of which were epicardial. The median ratio of RMCC ablated was 1 (IQR, 0.6‐1). During a median follow‐up of 44 months (IQR, 11‐49), the ratio of RMCC ablated was associated with freedom from recurrent VT (hazard ratio, 0.01; P = 0.049). Among nine patients with adequate MRI, 73% of RMCC were localized in LGE regions, 24% were adjacent to an area with LGE, and 3% were in regions without LGE.ConclusionSlow conduction channels within endocardial or epicardial ARVC scar were delineated clearly by ripple mapping and corresponded to critical isthmus sites during entrainment. Complete elimination of RMCC was associated with freedom from VT.
Anticoagulation after catheter ablation of atrial fibrillation: An unnecessary evil? A systematic review and meta‐analysis
Authors: Proietti Riccardo , AlTurki Ahmed , Di Biase Luigi , China Paolo , Forleo Giovanni , Corrado Andrea , Marras Elena , Natale Andrea , Themistoclakis Sakis 
Published: December 2018

AbstractBackgroundAnticoagulation in patients with atrial fibrillation (AF) is currently based on clinical parameters (CHA2DS
2‐VASc score) that have been shown to predict cerebrovascular events (CVE). Controversy exists as to whether CVE risk persists unmodified after successful catheter ablation, as observational studies suggest a lower risk of CVE. Current guidelines recommend continued oral anticoagulation (OAC) based on the CHA
2DS
2‐VASc score risk profile.MethodsWe conducted a systematic literature review of all studies published up to July 31, 2018, that reported CVE after catheter ablation of AF and compared patients on or off OAC. Random‐effects models were used to demonstrate the risk of CVE and major bleeding in on‐OAC vs off‐OAC patients. This analysis was further stratified by CHADS2 and CHA
2DS
2‐VASc score.ResultsWe retained 16 studies, 10 prospective cohort and 6 retrospective cohort, that met inclusion criteria, and which enrolled 25 177 patients: 13 166 off‐OAC and 12 011 on‐OAC. No significant difference in the incidence of CVE emerged between on‐OAC and off‐OAC patients after AF ablation (risk ratio, 0.66; confidence interval [CI], 0.38, 1.15). Similar results were found after stratification by CHADS2 and CHA
2DS
2‐VASc score. Off‐OAC patients suffered significantly less bleeding than those on OAC (RR, 0.17; CI, 0.09, 0.34). Of note, the percentage of patients with AF recurrence impacts the treatment effect in the two groups (
P = 0.001).ConclusionsIn this metanalysis, the risk‐benefit ratio favored the suspension of OAT after successful AF ablation even in patients at moderate‐high risk. Whether the reported results can be extended also to non‐vitamin K antagonist oral anticoagulants warrants further investigations.
Oncogenic comparison of human papillomavirus type 58 E7 variants
Authors: Law Priscilla TY , Boon Siaw Shi , Hu Chenghua , Lung Raymond WM , Cheung Grace PY , Ho Wendy CS , Chen Zigui , Massimi Paola , Thomas Miranda , Pim David , Banks Lawrence , Chan Paul KS 
Published: December 2018

AbstractHuman papillomavirus 58 (HPV58) ranks the second or third in East Asian cervical cancers. Current studies on HPV58 are scarce and focus on the prototype. Previously, we identified the three most common circulating HPV58 E7 strains contained amino acid alterations: G41R/G63D (51%), T20I/G63S (22%) and T74A/D76E (14%) respectively. Among them, the T20I/G63S variant (V1) had a stronger epidemiological association with cervical cancer. We therefore suggested that V1 possessed stronger oncogenicity than the other two variants. Here, we performed phenotypic assays to characterize and compare their oncogenicities with HPV58 E7 prototype. Our results showed that overexpression of V1 conferred a higher colony‐forming ability to primary murine epithelial cells than prototype (P < 0.05) and other variants, implicating its higher immortalising potential. Further experiments showed that both V1 and prototype enhanced the anchorage‐independent growth of NIH/3T3 cells (P < 0.001), implicating their stronger transforming power than the two other variants. Moreover, they possessed an increased ability to degrade pRb (P < 0.001), which is a major effector pathway of E7‐driven oncogenesis. Our work represents the first study to compare the oncogenicities of HPV58 E7 prototype and variants. These findings deepened our understanding of HPV58 and might inform clinical screening and follow‐up strategy.
How Chronic Is Polypharmacy in Old Age? A Longitudinal Nationwide Cohort Study
Authors: Wastesson Jonas W. , Morin Lucas , Laroche Marie‐Laure , Johnell Kristina 
Published: December 2018

OBJECTIVETo evaluate the chronicity of polypharmacy among older adults and to identify factors associated with chronic polypharmacy.DESIGNLongitudinal cohort study using register data.SETTINGNationwide, Sweden.PARTICIPANTSAll 711,432 older adults (aged 65 years and older) living in Sweden with five or more prescription drugs in October 2010 were included and followed up until December 2013. Mean age at baseline was 77 (SD = 7.8) years, 59% were women, and 7% lived in nursing homes.MEASUREMENTMonthly changes in the exposure to polypharmacy. Data regarding prescription drug use were extracted from the Swedish Prescribed Drugs Register.RESULTSOverall, 82% were continuously exposed to polypharmacy for 6 months or longer, and 74% for 12 months or longer. The proportion of individuals who remained exposed until the end of the study was 55%. Among the 21,361 individuals who had not been exposed to polypharmacy during the 6‐month period before baseline (ie, with a new episode of polypharmacy), only 30% remained exposed for 6 months or longer. The proportion of older adults who spent at least 80% of their follow‐up time with polypharmacy was substantially higher among prevalent polypharmacy users at baseline than among those with a new polypharmacy episode (80% vs 24%; P < .01). Factors associated with chronic polypharmacy included higher age, female sex, living in an institution, chronic multimorbidity, and multidose dispensing.CONCLUSIONPolypharmacy is most often chronic, although a substantial share of older adults experience short, recurring episodes of polypharmacy and are thus exposed to its potential harms in a transient rather than persistent manner. J Am Geriatr Soc 67:455–462, 2019.
Effect of Bisphosphonates on Fracture Outcomes Among Frail Older Adults
Authors: Zullo Andrew R. , Zhang Tingting , Lee Yoojin , McConeghy Kevin W. , Daiello Lori A. , Kiel Douglas P. , Mor Vincent , Berry Sarah D. 
Published: December 2018

BACKGROUNDBisphosphonates are seldom used in frail, older adults, in part due to lack of direct evidence of efficacy in this population and increasing concerns about safety.OBJECTIVEWe estimated the effects of bisphosphonates on hip fractures, nonvertebral fractures, and severe esophagitis among frail, older adults.DESIGNPopulation‐based retrospective cohort using 2008 to 2013 linked national Minimum Data Set assessments; Online Survey Certification and Reporting System records; and Medicare claims.SETTINGUS nursing homes (NHs).PARTICIPANTSLong‐stay NH residents 65 years and older without recent osteoporosis medication use (N = 24,571). Bisphosphonate initiators were 1:1 propensity score matched to calcitonin initiators (active comparator).MEASUREMENTSHospitalized hip fracture, nonvertebral fracture, and esophagitis outcomes were measured using part A claims. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated, controlling for over 100 baseline characteristics.RESULTSThe matched cohort included 5209 new bisphosphonate users and an equal number of calcitonin users (mean age [SD] = 85 [8] years; 87% female; 52% moderate‐severe cognitive impairment). Over a mean follow‐up of 2.5 (SD = 1.7) years, 568 residents (5.5%) had a hip fracture, 874 (8.4%) had a nonvertebral fracture, and 199 (1.9%) had a hospitalized esophagitis event. Users of bisphosphonates were less likely than calcitonin users to experience hip fracture (HR = 0.83; 95% CI = 0.71‐0.98), with an average gain in time without fracture of 28.4 days (95% CI = 6.0‐50.8 days). Bisphosphonate and calcitonin users had similar rates of nonvertebral fracture (HR = 0.91; 95% CI = 0.80‐1.03) and esophagitis events (HR = 1.11; 95% CI = 0.84‐1.47). The effects of bisphosphonates on fractures and esophagitis were generally homogeneous across subgroups, including those defined by age, sex, history of prior fracture, and baseline fracture risk.CONCLUSIONSUse of bisphosphonates is associated with a meaningful reduction in hip fracture among frail, older adults, but little difference in nonvertebral fracture or severe esophagitis. J Am Geriatr Soc 67:768–776, 2019.
Using all‐payer claims data for health surveillance of people with intellectual and developmental disabilities
Authors: Phillips K. G. , Houtenville A. J. , Reichard A. 
Published: December 2018

AbstractBackgroundTo address limitations and challenges associated with current health surveillance of people with intellectual and developmental disabilities (IDD), this study investigates the use of all‐payer claims data to identify and characterise this population.MethodAll‐payer claims data from 2010 to 2014 were used to study people with IDD in New Hampshire. Starting with the Centers for Medicare and Medicaid Services' algorithm, IDD was defined using ICD‐9 diagnosis codes. Additional ICD‐9 codes for developmental disabilities were included to build the knowledge base begun by recent research conducted on Medicaid claimants in five other states.ResultsFindings showed the enhanced algorithm offers a replicable and feasible way to conduct health surveillance of people with IDD at the state level.ConclusionSubstantive and significant differences between Medicaid and commercial claimants suggest that using all‐payer claims provides a richer and more complete method for health surveillance of people with IDD.