bluuebunny/crossref_metadata_2025_split huggingface dataset:
РАЗВИТИЕ ПРАКТИЧЕСКИХ УМЕНИЙ БЕЗОПАСНОСТИ ЖИЗНЕДЕЯТЕЛЬНОСТИ У ШКОЛЬНИКОВ В СОВРЕМЕННЫХ УСЛОВИЯХ
Authors: И.С. Минбулатова , З.Р. Рамазанова 
Published: November 2024

в статье рассматривается подход к навыкам и умениям учащихся в сфере безопасности жизнедеятельности в рабочих программах общеобразовательной организации. Обозначены основные педагогические проблемы, которые препятствуют совершенствованию навыков безопасного поведения учащихся в повседневной жизни. Предлагается существенно изменить педагогический подход к учебному процессу в пользу ориентации на практические занятия и отведения теоретического материала на самостоятельное изучение учащимися в качестве домашнего задания. Перечислены преимущества от перехода на практико-ориентированный образовательный процесс в сфере безопасности жизнедеятельности и обеспечения соответствия учебного процесса задачам рабочих программ безопасности жизнедеятельности начальной, средней и старшей школы.
the article considers an approach to the skills and abilities of students in the field of life safety in the work programs of a general education organization. The main pedagogical problems that hinder the improvement of the skills of safe behavior of students in everyday life are identified. It is proposed to significantly change the pedagogical approach to the educational process in favor of focusing on practical exercises and allocating theoretical material for independent study by students as homework. The advantages of switching to a practice-oriented educational process in the field of life safety and ensuring that the educational process meets the objectives of the work programs of life safety of primary, secondary and high schools are listed.
PENINGKATAN PERILAKU ASI EKSKLUSIF PADA IBU POSTPARTUM DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO
Authors: Wiyahya Anton , Dharmawan Aditya Dhimas , Yaniseh Anggi Sri , Divanti Eva , Khusnaini Hasna , Nurrohwinahyu Kholifatun , Fadhillah Septa Rahmah , Septyan Novita Tri , Septyarini Yesika , Sari Iis Purnama , Abdullah Effendi Mishbah , Riyanti Eka 
Published: November 2024

Air susu ibu atau ASI adalah makanan yang diproduksi secara alami dan memberikan suplai nutrisi yang lengkap bagi bayi baru lahir, dan mempunyai komponen anti inflamasi sehingga dapat memberi perlindungan bagi ibu dan anak dari penyakit. Tujuan dilakukan kegiatan ini adalah untuk meningkatkan tingkat pengetahuan dan perilaku ibu postpartum tentang ASI eksklusif. Metode yang sudah digunakan berbentuk ceramah, diskusi dan tanya jawab. Penyuluhan ini diikuti oleh 10 ibu post partum. Pengetahuan peserta diukur sebelum dan sesudah edukasi dilakukan. Didapatkan hasil bahwa tingkat pengetahuan ibu post partum sebelum diberikan edukasi breast feeding paling tinggi sejumlah 4 orang (40%) dan paling rendah sejumlah 6 orang (60%). Setelah diberikan edukasi breast feeding tingkat pengetahuan paling tinggi sejumlah 7 orang (70%) dan paling rendah sejumlah 3 orang (30%). Didapatkan hasil bahwa tingkat perilaku ibu post partum sebelum diberikan edukasi breast feeding paling tinggi sejumlah 5 orang (50%) dan paling rendah sejumlah 5 orang (50%). Setelah diberikan edukasi breast feeding tingkat pengetahuan paling tinggi sejumlah 8 orang (80%) dan paling rendah sejumlah 2 orang (20%).
Financial Framework for Non-Resource Exports to Foster the Dynamic Growth of the Russian Economy
Authors: Mamedov T. N. 
Published: November 2024

The relevance of the article is rooted in the critical role of the non-resource sector in the Russian economy, particularly in the face of increasing sanctions.The purpose of the article is to propose a comprehensive framework for ﬁnancial assistance to non-resource exports, fostering the sustained growth of the Russian economy in the current context.Methods: the research methodology is based on general and special methods of cognition; analysis of reports of international organizations, ofﬁcial databases of statistical data, normative documents, monographs and scientiﬁc publications.Scientiﬁc novelty: Drawing on the analysis of successful international approaches, we have developed a holistic framework for ﬁnancial assistance to non-traditional exports in Russia. This framework is designed to complement the national project “International Cooperation and Export”, which is focused on implementing the Strategy for the Development of Foreign Economic Activity of the Russian Federation until 2030.Research results: The article explores the global experience of comprehensive export support systems and suggests ﬁnancial measures to help Russian manufacturers of industrial products.Practical signiﬁcance of the article lies in the fact that the ﬁnancial instruments developed for non-primary non-energy exports can be used in the implementation of the Federal National Project “International Cooperation and Export”.
The content of TBA-positive products in embryos of loach Misgurnus fossilis L. at different stages of development under the influence of amino acid derivatives of 1,4-naphthoquinone
Authors:   Ivan Franko Lviv National University, Heneha A. , Tarnovska A. ,   Ivan Franko Lviv National University, Yaremchuk M. ,   Ivan Franko Lviv National University, Budevych A. ,   Ivan Franko Lviv National University, Semochko O. ,   Danylo Halytsky Lviv National Medical University
Published: November 2024

Naphthoquinones play an important role among natural substances and their synthetic derivatives, as they have a wide range of biological activity. Amino acid derivatives of 1,4-naphthoquinone have prospects for practical use in medicine and pharmacology. To clarify the possible mechanism of action of amino acid derivatives of 1,4-naphthoquinone, the content of TBA-positive products in embryonic cells of the loach Misgurnus fossilis L. during embryogenesis was investigated. Embryos of the freshwater fish loach Misgurnus fossilis L. are a convenient and adequate system for elucidating the mechanisms of action of physical and chemical factors. It has been established that the glutamine derivative of 1,4-naphthoquinone has the most pronounced biological effects and caused significant changes in TBK-positive products during embryogenesis relative to the control at stages 2 and 256 blastomeres (60 and 270 minutes of embryo development) by 47 % and 43 %, respectively (p≥0.99). At stages 16 and 64 blastomeres, there is a tendency to increase the content of MDA under the action of the glutamine derivative of 1,4-naphthoquinone at a concentration of 10-5 M compared to the control. Also, at the 10th division stage under the influence of the glutamine derivative of 1,4-naphthoquinone, the MDA content decreases by 2 % compared to the control sample, possibly due to the activation of enzymatic systems of antioxidant protection. Increasing the intensity of lipid peroxidation processes stimulates the activation of antioxidant system enzymes. Therefore, to analyze the prooxidant-antioxidant state of loach embryos, it is necessary to study the activity of enzymes that provide antioxidant protection. The obtained results allow us to suggest that under the action of the derivative of 1,4-naphthoquinone, activation of lipid peroxidation processes occurs in embryonic cells of the loach Misgurnus fossilis L. during embryogenesis.
Effect of a thiazole derivative on the activity of antioxidant enzymes in murine lymphoma cells
Authors:   Ivan Franko National University of Lviv, Shalai Ya. , Koberenko V. ,   Ivan Franko National University of Lviv, Ilkiv M. ,   Ivan Boberskyi Lviv State University of Physical Culture, Ostapiuk Yu. ,   Ivan Franko National University of Lviv, Babsky A. ,   Ivan Franko National University of Lviv
Published: November 2024

Previous in vitro studies have demonstrated a pronounced cytotoxic effect of the thiazole derivative N-(5-Benzyl-13-thiazole-2-yl)-35-dimethyl-1-benzofuran-2-carboxami­de (BF1) on tumor cells. Additionally, it has been determined that scavengers of reactive Oxygen species (ROS) significantly reduce the cytotoxic effect of BF1. In this study, the influence of BF1 on the activity of superoxide dismutase (SOD) and catalase (CAT), both normally and in the presence of ascorbic acid, in mouse Nemeth-Kellner lymphoma (NK/Ly) cells has been studied to evaluate the possible role of antioxidant activity during the action of this substance. The experiments were performed using nonlinear male mice weighing 20–30 g. Intraperitoneal inoculation of 10–15 million cancer cells into the mice induced the ascites form of lymphoma. The thiazole derivative (BF1) was dissolved in dimethyl sulfoxide and added to the test samples at 1, 10, and 50 μM final concentrations. Superoxide dismutase (SOD) and catalase (CAT) activities were determined spectrophotometrically in a homogenate of the lymphoma cells after incubation with the drug for 30 minutes. The baseline level of SOD in the lymphoma of the mice was 0.33±0.02 activity units/min×mg protein. BF1 significantly increased the enzyme activity by 35 % and 29 % at concentrations of 10 (p<0.01) and 50 μM (p<0.05), respectively. The baseline level of CAT activity was 4.61±0.17 nmoles H2O2/min×mg protein, and this significantly decreased by 15 % (p<0.05) and 20 % (p<0.01) following the action of the thiazole derivative at a concentration of 10 and 20 μM, respectively. The increase of SOD activity, coupled with a decrease or absence of changes in CAT activity, may be cytotoxic to cancer cells. Simultaneously, upon the addition of ascorbic acid as a scavenger of ROS to the environment, the activities of SOD and CAT did not change under the action of BF1 at any of the investigated concentrations. Therefore, the effect of the thiazole derivative BF1 has been canceled in the presence of ROS scavengers in the environment. This may indicate the dependence of the cytotoxic effect of BF1 on the presence of ROS in tumor cells.
Assessment of Physocarpus opulifolius (L.) Maxim. and Stachys palustris L. extracts influence against Candida parapsilosis
Authors:   Ivan Franko National University of Lviv, Yavorska H. , Vorobets N. ,   Danylo Halytsky Lviv National Medical University, Moroz O. ,   Ivan Franko National University of Lviv
Published: November 2024

The opportunistic fungi Candida parapsillosis are increasingly causing various diseases. They can be commensals, but, having unique properties of invasiveness, virulence and antifungal sensitivity, which is characteristic of fungi of this genus in general, in newborns and people with weakened immunity or those who use catheters, they become destroyers of body tissues. These fungi are capable of forming strong biofilms on catheters and other implanted medical devices, threatening the lives of patients undergoing invasive medical procedures. In the era of the spread of antibiotic resistance, the search for auxiliary and alternative means to avoid dissemination or treatment of the disease after the detection of the causative agent is urgent. These can be substances of plant origin, in particular, little-studied, from the point of view of antifungal properties, Stachys palustris and Physocarpus opulifolius. Aqueous-ethanol (AE) extracts from these species have been found to have potential anti-candidal properties against Candida parapsilosis, which were determined by agar diffusion and media addition methods. AE extracts of these species inhibited the growth of Candida parapsilosis more than aqueous extracts. Stachys palustris extracts made with 70 % and 95 % AE and Physocarpus opulifolius extracts made with 60 % and 95 % AE caused diameter of inhibition zone (IZ) greater than 13 mm, but their effect was half that of fluconazole and slightly more, compared to tinctures of sage and eucalyptus. An extract of Stachys palustris made with 95 % aqueous ethanol was most effective, causing IZ, of up to 20 mm. The extract of S. palustris prepared with 95 % ethanol suppresses the growth of the culture when present in the medium in ratios of 1:2, 1:4 and 1:6, and the similarly prepared extract of Physocarpus opulifolius – 1:2 and 1:4. The rapid microplate method for determining the effect of plant extracts on microorganisms with resazurin can be used only after additional confirmation, since the extracts themselves are able to regenerate the indicator.
Зобов’язання гейткіперів, закріплені в Акті про цифрові ринки
Authors: МАЗАРАКІ Наталія , ЖИБАК Андрій 
Published: November 2024

Зловживання цифровими гігантами своєю економічною владою окреслило проблематику спотворення конкуренції на ринку онлайн-послуг та виявило неефективність традиційного конку­рентного права. Це стало поштовхом до прий­няття Акта про цифрові ринки, спрямованого на специфічне регулювання цифрового сектору шляхом встановлення правил, що забезпечують конкуренто­спроможність та справедливість на внутрішньому ринку ЄС. Гіпотеза дослідження полягає у під­твердженні переваг зобовʼязань ex ante, які DMA накладає на онлайн-платформи зі статусом гейт­кіпер, щодо зміцнення справедливості та конку­рентності, а також забезпечення прав бізнес-користувачів і споживачів у цифровому секторі економіки. Метою дослідження є функціональна характеристика зобовʼязань онлайн-платформ зі статусом гейткіпер та визначення перспектив їх реалізації. Для досягнення мети використано методику доктринального аналізу, яка допомогла розкрити правову природу й особливості Акта про цифрові ринки в цілому, а також зобовʼязань гейткіперів зокрема. Зобовʼязання ex ante, як пове­дінкові засоби правової охорони ринку ЄС від нега­тивної ділової практики, спрямовані на недо­пу­щення потенційно небажаної поведінки гейткіперів, а також сприяють внутрішньо- і міжплатформній конкуренції та захищають її. Доведено, що асимет­ричність регулювання ex ante, конкурентність і справедливість цифрових ринків як ціль регулю­вання, самовиконуваний характер зобовʼязань свідчать про новизну регуляторного режиму, запровадженого Актом про цифрові ринки. Надання Європейській комісії широкого кола повно­важень щодо контролю за виконанням онлайн-платформами зобовʼязань додає гнучкості регуля­торному інстру­менту, який водночас потребує подальшого розвитку для того, щоб суттєво відрізнятися від тради­ційного конкурентного права.
Middle fossa approach for a petrous apex bony spur causing trigeminal neuralgia: illustrative case
Authors: Hamrick Forrest , Colby Samantha , Couldwell William T. , Rahimpour Shervin 
Published: November 2024

BACKGROUND
Trigeminal neuralgia (TN) can arise from trigeminal nerve compression at the root entry zone due to neurovascular conflict, which most often presents in the 6th decade of life. The authors report the case of a young patient with TN with a petrous apex bony spur near the entrance of Meckel’s cave, causing compression of the proximal trigeminal nerve.

OBSERVATIONS
A 21-year-old woman presented with a 5-year history of progressive right-sided TN. Axial T2 sampling perfection with application optimized contrast using different flip angle evolution magnetic resonance imaging (MRI) did not reveal vascular compression of the trigeminal nerve. However, sagittal reformats demonstrated a prominent bony ridge along the petrous apex, causing compression of the right trigeminal nerve at the porus trigeminus. Removal of the bony spur via a middle fossa approach completely resolved the patient’s symptoms.

LESSONS
Although TN is most frequently caused by neurovascular compression, it is vital to examine the entire course of the trigeminal nerve on MRI to identify alternative causes of nerve compression in the absence of neurovascular conflict. Bony compression is a rare cause of TN that should be considered, particularly in younger patients. The presence of prominent osseous structures along the course of the trigeminal nerve can be evaluated reliably on sagittal MRI.
https://thejns.org/doi/10.3171/CASE24321
Revascularization with superficial temporal artery–middle cerebral artery anastomosis in spontaneous intracranial internal carotid artery dissection: illustrative case
Authors: Nounaka Yohei , Matano Fumihiro , Fujita Hiroaki , Isayama Koshiro , Ideguchi Minoru , Murai Yasuo 
Published: November 2024

BACKGROUND
Because of ischemic symptoms, intracranial internal carotid artery (IICA) dissection has no established treatment guidelines. The authors report a case of IICA dissection in which an emergency superficial temporal artery–middle cerebral artery (STA-MCA) bypass was performed.

OBSERVATIONS
A 46-year-old woman presented with a headache and left hemiplegia. Her cortical symptoms appeared on day 10, and an STA-MCA bypass was performed because of cerebral hypoperfusion. Her postoperative patency was good, and cortical symptoms improved. Contrast-enhanced magnetic resonance imaging (MRI) was performed in the acute phase with wall contrast. From day 18, the internal carotid artery delineation improved, and the patient was transferred for rehabilitation without worsening symptoms. A literature review of spontaneous IICA dissection with revascularization procedures was conducted to discuss the indications, timing, treatment modalities, and surgical outcomes.

LESSONS
The STA-MCA bypass provides supplemental cerebral blood flow and can prevent critical complications. Contrast-enhanced MRI in the acute phase of dissection can show a wall contrast effect and assist in predicting disease progression.
https://thejns.org/doi/10.3171/CASE24332
Perioperative management of patients with glioblastoma copresenting with pheochromocytoma: illustrative case
Authors: Guo Eddie , Keough Michael B. , Henderson Amanda M. , Hagen Evan M. , Levine Max A. , Arnason Terra , Au Karolyn 
Published: November 2024

BACKGROUND
Undiagnosed pheochromocytoma can present with hemodynamic instability during surgical procedures. Here, the authors discuss a 69-year-old male with isocitrate dehydrogenase (IDH)–wildtype glioblastoma copresenting with undiagnosed pheochromocytoma, which, to the authors’ knowledge, is the second reported case in the literature.

OBSERVATIONS
The patient presented to the emergency department with a 1-month history of coordination difficulties, progressive morning headache, and mild left-side weakness. Imaging showed a 5-cm peripherally enhancing intra-axial right parietal mass with surrounding vasogenic edema. Intraoperatively, the patient had significant uncontrollable hypertension up to 240/120 mm Hg, and the operation was promptly aborted. Contrast-enhanced computed tomography imaging of the chest, abdomen, and pelvis identified a 4.9-cm left adrenal mass of indeterminant etiology. Endocrinology diagnosed the incidentaloma as a pheochromocytoma, initiating alpha blockade followed by beta blockade, and the urology service performed a laparoscopic adrenalectomy after patient stabilization. The neurosurgery service removed the intra-axial brain lesion 2 days after adrenalectomy, which was diagnosed as IDH-wildtype glioblastoma. The patient was discharged home after 6 days in stable condition.

LESSONS
This case highlights the importance of preoperative screening for pheochromocytoma in neurosurgical patients with adrenal incidentalomas, especially in incidentalomas > 4 cm, even without high clinical suspicion.
https://thejns.org/doi/10.3171/CASE24374
Progressive headache and neck pain associated with neck rotation due to a congenital external carotid–jugular arteriovenous fistula: illustrative case
Authors: Yokochi Yasunori , Ikeda Hiroyuki , Hayashi Tomoko , Uezato Minami , Kinosada Masanori , Kurosaki Yoshitaka , Chin Masaki 
Published: November 2024

BACKGROUND
Congenital external carotid–jugular arteriovenous fistulas (AVFs) are often diagnosed based on a pulsatile neck mass. Patients rarely complain of headaches or neck pain.

OBSERVATIONS
A 45-year-old woman with no history of trauma had been diagnosed with a congenital cervical external carotid AVF 10 years earlier. At that time, only a pulsatile neck mass in the right neck had been observed, and she had been managed conservatively. Over the next 10 years, the right neck mass had enlarged, and she started experiencing unbearable headaches and neck pain when she turned her head. Angiography images showed that the outflow veins, including the external and internal jugular veins, were more dilated and tortuous than they had been 10 years earlier. During neck rotation, the internal jugular vein constricted, causing intracranial venous reflux. Complete occlusion of the shunt was achieved with coils and n-butyl-2-cyanoacrylate. Immediately after surgery, the pulsation in the right neck, the unbearable headaches, and neck pain on neck rotation resolved.

LESSONS
Even in adults with congenital cervical external carotid AVFs that have been managed as simple neck masses, progressive dilatation and tortuosity of the outflow veins can, over time, lead to venous reflux during neck rotation and can cause unbearable headaches and neck pain.
https://thejns.org/doi/10.3171/CASE24407
Convexity dural hemangioma: illustrative case
Authors: Hayden Ellery A. , Leoni Jack A. , Culicchia Frank 
Published: November 2024

BACKGROUND
Dural hemangiomas are a relatively rare form of intracranial mass, as hemangiomas tend to present in bone or as intraparenchymal lesions and only around 5%–13% have been reported to originate from the dura mater. Here, the authors present the case of a 46-year-old female who underwent craniotomy for a suspected convexity meningioma resection, which was unexpectedly found to be a dural capillary hemangioma.

OBSERVATIONS
The patient was a 46-year-old female who presented with a left frontal intracranial mass found incidentally and showed significant growth over 4 years. The mass was suspected to be a meningioma as it was homogeneously enhancing, extra-axial, and exhibited findings of a broad base with a dural tail along the dura of the superior frontal lobe. This was excised en bloc and found to be a purplish-red mass firmly attached to the dura, which was diagnosed as a capillary hemangioma on histopathology.

LESSONS
Dural hemangiomas, particularly at the convexity, are quite rare and can mimic meningiomas on imaging, sometimes even demonstrating homogeneous enhancement with a broad base and dural tail. These are an important part of the differential diagnosis when diagnosing dural-based masses and should be considered when planning operative or radiation treatment.
https://thejns.org/doi/10.3171/CASE24476
Failed ulnar nerve surgery due to persistent unrecognized snapping triceps from cubitus varus due to a distal humeral malunion in an adult: illustrative case
Authors: O’Driscoll Christopher J. L. , Spinner Robert J. 
Published: November 2024

BACKGROUND
Snapping triceps is a dynamic condition in which a portion of the medial head of the triceps dislocates over the medial epicondyle during flexion or extension. Pushed by the triceps, the ulnar nerve typically also dislocates over the medial epicondyle, causing neuropathy. Posttraumatic cubitus varus deformities resulting from pediatric supracondylar fractures have been associated with snapping triceps. This is the first case of snapping triceps associated with cubitus varus due to distal humeral malunion, which occurred in an adult.

OBSERVATIONS
A 23-year-old man sustained a left distal humeral fracture from arm wrestling, which was treated nonoperatively, healing in a varus malunion. Within several months, he developed ulnar neuropathy and snapping at the medial elbow, which was diagnosed as a dislocating ulnar nerve and was treated with ulnar nerve transposition. He presented 8 years later with continued ulnar neuritis symptoms and snapping and was found to have snapping medial triceps. He chose nonoperative treatment.

LESSONS
Snapping triceps, presenting as snapping at the elbow with ulnar nerve symptoms, can be incorrectly diagnosed as isolated ulnar nerve dislocation. Unrecognized snapping triceps leads to persistent symptoms after ulnar nerve transposition. The patient in this case demonstrated that an altered triceps line of pull can cause snapping triceps regardless of how the cubitus varus originated.
https://thejns.org/doi/10.3171/CASE24596