bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current status of stroke in Qatar: Including data from the BRAINS study
Authors: Jallow Ebrima , Al Hail Hassan , Han Thang S , Sharma Sapna , Deleu Dirk , Ali Musab , Al Hussein Hassan , Abuzaid Hassan O , Sharif Khalid , Khan Fahmi Y , Sharma Pankaj 
Published: August 2019

Background Qatar is located on the north-eastern coast of the Arabian Peninsula. Qatari natives account for less than 15% of the population while the largest migrant group comprising 60% derives from South Asia. Despite projections that stroke burden in Qatar will increase with population ageing, epidemiological studies focusing on stroke in Qatar are relatively scarce. Method We reviewed the available epidemiological publications relating to Qatar. In addition, we have added to this knowledge by incorporating Qatari data from the on-going Bio-Repository of DNA in Stroke, an independent multinational database of stroke patients. Results Qatar has low reported incidence and mortality rates of 58 and 9.17 per 100,000 per year, respectively, which may be explained by its middle-aged migrant worker majority population. Correspondingly, South Asian migrants in Qatar suffered younger strokes than Qatari natives (48.7 vs 63.4 years, P < 0.001). Among the most common risk factors identified in stroke patients were hypertension (77.9%), diabetes (43.8%) and hypercholesterolemia (28.5%). Ischaemic stroke was the most frequent subtype amongst migrant South Asians (71.1%). The majority of stroke cases had computed tomography and/or magnetic resonance imaging scans, but only 11.1% of ischaemic strokes were thrombolysed. Qataris on one-year follow up were more often found to have died (6.5% vs 0.3%) and had further stroke/transient ischaemic attack events (17.4% vs 6.4%, P = 0.009) compared to South Asians. Conclusion The burden of stroke is increasing in Qatar, and considerable disparities are observed between the native and migrant populations which likely will require different approaches to management by its healthcare system.
Public knowledge and attitude toward lumbar puncture among adults in Riyadh, Saudi Arabia: A cross-sectional study
Authors: Aldayel Abdulrahman Yousef , Alharbi Muteb Mousa , Almasri Mohammed Saud , Alkhonezan Saleh Mansoor 
Published: August 2019

Objective: The aim of this study is to evaluate knowledge of and attitudes toward the lumbar puncture procedure among adults in Riyadh region, Saudi Arabia, 2018. Methods: This study used a quantitative cross-sectional evaluation of the responses of adults aged ⩾18 years from the Saudi Telecom Company database in the Riyadh region of Saudi Arabia to an online survey between October and December 2018. The questionnaire included questions on knowledge, attitudes, and demography. The questionnaire was pretested and validated (Cronbach’s alpha = 0.701). Results: Of 1500 questionnaires, 1223 (81.5%) were returned and included in the analysis. In the study, 57.7% of the participants were aged 18–25 years, and 58.5% of the participants were females. Only 235 (19.2%) participants had an accepted knowledge level of lumbar puncture. The attitudes of the majority of the participants ( n = 1151, 94%) to lumbar puncture were acceptable. A multivariate logistic regression test revealed a significant association between an acceptable knowledge level and acceptable attitude level (odds ratio = 2.30, 95% confidence interval = 1.06–5.66). A significant association was also found with ages over 46 years old (odds ratio = 12.99, 95% confidence interval = 4.45–37.9). The attitudes level toward lumbar puncture had a significant negative association among the participants who had a fear of injections in the lumbar region (odds ratio = 0.46, 95% confidence interval = 0.3–0.68). Conclusion: There is a lack of appropriate knowledge of the lumbar puncture procedure among the public which predict an unacceptable attitude toward lumbar puncture. Improvements in public education could improve public awareness of the clinical importance/value and complications of lumbar puncture.
The modified anterolateral approach to the humerus
Authors: Chang Angela Christine , Ha Ngoc Buu , Sagar Christopher , Bain Gregory Ian , Leonello Domenic Thomas 
Published: August 2019

Introduction: The anterior and anterolateral approaches to the humerus describe splitting brachialis longitudinally, assuming its fibres run parallel to the shaft. Recent improvements in the understanding of brachialis anatomy however have demonstrated it has two distinct heads, with the bulk of its fibres running oblique relative to the humerus. Attempting to split brachialis longitudinally to the extent required for plate osteosynthesis invariably leads to transection of a significant number of muscle fibres. The authors present a less muscle destructive modification to the anterolateral approach (ALA) based on a bicipital brachialis muscle. Method: In order to preserve brachialis muscle fibres, the modified ALA elevates the superficial head from the underlying humerus and longitudinally splits the deep head to allow a fixation device to be tunnelled. Case notes of patients with a humeral shaft fracture fixed via the modified ALA were retrospectively reviewed. Results: Ninteen humeral shaft fractures were fixed via the modified ALA. No post-operative nerve palsies were reported. Of the 19 patients, 14 (73.7%) received clinical and radiological follow-up. All reported being satisfied with their outcome. One developed a superficial wound infection and one (previous diagnosis of spondyloepiphyseal dysplasia tarda) developed a non-union requiring revision surgery. Of the five patients lost to follow-up, two died, and three reported no ongoing orthopaedic issues via telephone. Conclusions: Improved anatomical understanding of brachialis has resulted in the described modification to the ALA which is less muscle destructive and follows a truer inter-nervous plane. This small series demonstrates satisfactory outcomes using this approach.
Nonmyeloablative TLI-ATG conditioning for allogeneic transplantation: mature follow-up from a large single-center cohort
Authors: Spinner Michael A. , Kennedy Vanessa E. , Tamaresis John S. , Lavori Philip W. , Arai Sally , Johnston Laura J. , Meyer Everett H. , Miklos David B. , Muffly Lori S. , Negrin Robert S. , Rezvani Andrew R. , Shizuru Judith A. , Weng Wen-Kai , Hoppe Richard T. , Strober Samuel , Lowsky Robert 
Published: August 2019

AbstractNonmyeloablative total lymphoid irradiation and antithymocyte globulin (TLI-ATG) conditioning is protective against graft-versus-host disease (GVHD), while retaining graft-versus-tumor activity across various hematologic malignancies. We report our comprehensive experience using TLI-ATG conditioning in 612 patients with hematologic malignancies who underwent allogeneic transplantation at Stanford University from 2001 to 2016. All patients received granulocyte colony-stimulating factor–mobilized peripheral blood grafts and cyclosporine and mycophenolate mofetil for GVHD prophylaxis. The median age was 60 years (range, 21-78), with a median follow-up of 6.0 years (range, 1.0-16.4). Common diagnoses included acute myeloid leukemia (AML; n = 193), myelodysplastic syndrome (MDS; n = 94), chronic lymphocytic leukemia (CLL; n = 80), non-Hodgkin lymphoma (NHL; n = 175), and Hodgkin lymphoma (HL; n = 35). Thirty-four percent of patients had a comorbidity index ≥3, 30% had a high to very high disease risk index, and 56% received unrelated donor grafts, including 15% with HLA-mismatched donors. Ninety-eight percent underwent transplant in the outpatient setting, and 57% were never hospitalized from days 0 through 100. The 1-year rates of nonrelapse mortality (NRM), grade II-IV acute GVHD, and extensive chronic GVHD were 9%, 14%, and 22%, respectively. The 4-year estimates for overall and progression-free survival were 42% and 32% for AML, 30% and 21% for MDS, 67% and 43% for CLL, 68% and 45% for NHL, and 78% and 49% for HL. Mixed chimerism correlated with the risk of relapse. TLI-ATG conditioning was well tolerated, with low rates of GVHD and NRM. Durable remissions were observed across hematologic malignancies, with particularly favorable outcomes for heavily pretreated lymphomas. Several efforts are underway to augment donor chimerism and reduce relapse rates while maintaining the favorable safety and tolerability profile of this regimen.
Normal peripheral blood neutrophil numbers accompanying ELANE whole gene deletion mutation
Authors: Horwitz Marshall S. , Laurino Mercy Y. , Keel Siobán B. 
Published: August 2019

Key Points
The patient reported here, along with collective observations in the literature, suggest that ELANE deletion does not cause neutropenia. Potential therapeutic genome editing involving knockout of the mutant ELANE allele is therefore not expected to produce neutropenia.
Identification and Confirmation of Potentially Actionable Germline Mutations in Tumor-Only Genomic Sequencing
Authors: Clark Dana Farengo , Maxwell Kara N. , Powers Jacquelyn , Lieberman David B. , Ebrahimzadeh Jessica , Long Jessica M. , McKenna Danielle , Shah Payal , Bradbury Angela , Morrissette Jennifer J.D. , Nathanson Katherine L. , Domchek Susan M. 
Published: August 2019

PURPOSE Tumor-only genomic profiling (TGP) is increasingly advocated for all patients with cancer given the possible therapeutic implications. It is critical to develop clinical algorithms to identify and address potentially actionable germline findings identified by TGP. METHODS A multidisciplinary team analyzed publicly available data for genes in which mutations are implicated in germline cancer susceptibility and established a pipeline to automate clinical referral for evaluation of TGP findings. RESULTS A total of 2,308 patients underwent TGP, with 81 patients (3.5%) identified by the automatic referral pipeline; 37 patients (1.6%) were referred outside the pipeline based on concerns by the molecular geneticist, pathologist, or oncologist regarding genotype-phenotype correlation. Thirty-one patients (38%) and 17 patients (46%) underwent germline testing from the automatic pipeline and other referrals, respectively, and of these patients, 23 (72%) and four (24%) had confirmed germline pathogenic variants (GPVs), respectively. The majority of confirmed GPVs were in automatic referral genes, with BRCA2 being most common (confirmed GPVs in 11 [85%] of 13 patients tested), followed by PALB2 (five [67%] of six patients), BRCA1 (two [40%] of five patients), MSH6 (two of three patients), and MLH1 (two of two patients). Forty-eight percent of confirmed GPVs were found in tumors known to be associated with germline mutations in the gene. Germline testing was not performed in 50 (62%) of 81 patients identified by automatic referral as a result of poor patient health or death (30%), lack of follow-up (30%), and patient refusal (30%). CONCLUSION Of patients undergoing TGP, 5% had somatic findings triggering referral, and implementation of an automatic referral pipeline based solely on gene versus other clinical or molecular features resulted in a 74% germline confirmation. However, only 41% of referred patients underwent germline testing. Systems-based approaches are needed to identify carriers of actionable germline cancer susceptibility mutations identified by TGP.
Heinrich Reichert (1949-2019)
Authors: Sen Sonia , VijayRaghavan K. 
Published: August 2019

ABSTRACT
Heinrich Reichert, Professor Emeritus at the University of Basel, Switzerland, passed away on the 13th of June 2019 after a prolonged illness. Heinrich described himself as ‘a hedonist when it came to science’ because he said it gave him great pleasure. It was this quality that made working with Heinrich thrilling and deeply fulfilling. Heinrich's long and versatile career spanned the breadth of neuroscience – from development, to evolution and behaviour. In his passing we have lost not just an astute scientist, but also an impassioned educator and an adventurer of science.
Phosphorylation of connexin 43 at MAPK, PKC or CK1 sites each distinctly alter the kinetics of epidermal wound repair
Authors: Lastwika Kristin J. , Dunn Clarence A. , Solan Joell L. , Lampe Paul D. 
Published: August 2019

ABSTRACT
The gap junction protein connexin 43 (Cx43) is a key player in wound healing, and inhibitors of Cx43, which speed epidermal wound healing, are currently in clinical trials. Here, we provide direct in vivo evidence that specific phosphorylation events on Cx43 change the physiological response during wound healing. Blocking phosphorylation, through mutation of serine residues in Cx43 at the protein kinase C (PKC) or casein kinase 1 (CK1) sites, significantly slowed the rate of wound closure in vivo and in vitro and resulted in a thicker epidermal layer after reepithelialization. Conversely, preventing Cx43 phosphorylation by mitogen-activated protein kinases (MAPKs) through mutation significantly increased the rate of wound closure in vivo. Defects in migration, but not proliferation, in all mutants were partially rescued in vitro by changing serine residues to aspartic or glutamic acid. These data prove that specific Cx43 phosphorylation events play an important role at different stages of wound healing. Thus, a clear physiological understanding of the spatiotemporal regulation of kinase activation and consequent effects on gap junctions could lead to a more targeted approach to modulating Cx43 expression during wound healing.
Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia
Authors: MOTIANI KUMAIL K. , COLLADO M. CARMEN , ESKELINEN JARI-JOONAS , VIRTANEN KIRSI A. , LÖYTTYNIEMI ELIISA , SALMINEN SEPPO , NUUTILA PIRJO , KALLIOKOSKI KARI K. , HANNUKAINEN JARNA C. 
Published: August 2019

ABSTRACT

Introduction
Intestinal metabolism and microbiota profiles are impaired in obesity and insulin resistance. Moreover, dysbiotic gut microbiota has been suggested to promote systemic low-grade inflammation and insulin resistance through the release of endotoxins particularly lipopolysaccharides. We have previously shown that exercise training improves intestinal metabolism in healthy men. To understand whether changes in intestinal metabolism interact with gut microbiota and its release of inflammatory markers, we studied the effects of sprint interval (SIT) and moderate-intensity continuous training (MICT) on intestinal metabolism and microbiota in subjects with insulin resistance.

Methods
Twenty-six, sedentary subjects (prediabetic, n = 9; type 2 diabetes, n = 17; age, 49 [SD, 4] yr; body mass index, 30.5 [SD, 3]) were randomized into SIT or MICT. Intestinal insulin-stimulated glucose uptake (GU) and fatty acid uptake (FAU) from circulation were measured using positron emission tomography. Gut microbiota composition was analyzed by 16S rRNA gene sequencing and serum inflammatory markers with multiplex assays and enzyme-linked immunoassay kit.

Results
V˙O2peak improved only after SIT (P = 0.01). Both training modes reduced systematic and intestinal inflammatory markers (tumor necrosis factor-α, lipopolysaccharide binding protein) (time P < 0.05). Training modified microbiota profile by increasing Bacteroidetes phylum (time P = 0.03) and decreasing Firmicutes/Bacteroidetes ratio (time P = 0.04). Moreover, there was a decrease in Clostridium genus (time P = 0.04) and Blautia (time P = 0.051). Only MICT decreased jejunal FAU (P = 0.02). Training had no significant effect on intestinal GU. Colonic GU associated positively with Bacteroidetes and inversely with Firmicutes phylum, ratio Firmicutes/Bacteroidetes and Blautia genus.

Conclusions
Intestinal substrate uptake associates with gut microbiota composition and whole-body insulin sensitivity. Exercise training improves gut microbiota profiles and reduces endotoxemia.
Augmented-Feedback Training Improves Cognitive Motor Performance of Soccer Players
Authors: HICHEUR HALIM , CHAUVIN ALAN , CAVIN VINCENT , FUCHSLOCHER JOERG , TSCHOPP MARKUS , TAUBE WOLFGANG 
Published: August 2019

ABSTRACTPurposeIn this study, we tested the hypothesis that augmented feedback (AF) training can improve both perceptual–cognitive and/or motor skills specific to soccer.MethodsThree groups of young elite players (U14–U15 categories) performed a test consisting in passing the ball as accurately and as quickly as possible toward a visual target moving briefly across a large screen located at 6 m from the player. The performed task required players to correctly perceive the target, anticipate its future location, and to adequately adjust the pass direction and power. The control group (CON) performed normal soccer training and was compared with two visuomotor training groups (AF and no-feedback [NF]) that followed the same training regime but integrated series of 32 passes three times per week over a 17-d period into their normal soccer training. Objective measurements of the passing performance were provided using a high-technology system (COGNIFOOT) before, during, and after training. During training, only players of the AF group received visuoauditory feedback immediately after each trial informing them about the accuracy of their passes.ResultsThe results show that only players of the AF group significantly improved passing accuracy, reactiveness, and global passing performance (+22%), whereas the NF group only improved passing accuracy. None of these parameters was improved in the CON group. The objectively measured changes in passing performance were compared with the more subjectively judged passing performance provided by coaches and players. Coaches’ judgments were more reliable than players’ judgments and exhibited a training group effect comparable to the ones objectively measured by COGNIFOOT.ConclusionsThis study provides evidence that the training of cognitive motor performance in soccer players highly benefits from the use of augmented feedback.
Curation of an intensive care research dataset from routinely collected patient data in an NHS trust.
Authors: McWilliams Chris , Inoue Joshua , Wadey Philip , Palmer Graeme , Santos-Rodriguez Raul , Bourdeaux Christopher 
Published: August 2019

In this data note we provide the details of a research database of 4831 adult intensive care patients who were treated in the Bristol Royal Infirmary, UK between 2015 and 2019. The purposes of this publication are to describe the dataset for external researchers who may be interested in making use of it, and to detail the methods used to curate the dataset in order to help other intensive care units make secondary use of their routinely collected data. The curation involves linkage between two critical care datasets within our hospital and the accompanying code is available online. For reasons of data privacy the data cannot be shared without researchers obtaining appropriate ethical consents. In the future we hope to obtain a data sharing agreement in order to publicly share the de-identified data, and to link our data with other intensive care units who use a Philips clinical information system.
Opinión de futuros equipos docentes de educación primaria sobre la implementación del mobile learning en el aula
Authors: Hinojo Lucena Francisco Javier , Aznar-Díaz Inmaculada , Cáceres-Reche María Pilar , Romero-Rodríguez José María 
Published: August 2019

Las tecnologías de la información y comunicación (TIC) son una tendencia a implementar en el ámbito educativo. En concreto, la universalización en el uso de los dispositivos móviles ha posibilitado su aplicación en diferentes etapas educativas. El objetivo de este trabajo ha sido conocer la opinión de futuros equipos docentes de educación primaria sobre la implementación del mobile learning en el aula. La metodología empleada es de corte cuantitativo, con la finalidad de describir la realidad observada en una muestra de estudiantado universitario del grado en Educación Primaria de la Universidad de Granada. Así mismo, se utilizó como instrumento de recogida de datos un cuestionario elaborado ad hoc, con base en una escala Likert de 4 niveles. El análisis de los datos se ha realizado mediante el software de análisis estadístico SPSS y AMOS. Entre los resultados se resalta la percepción positiva del estudiantado sobre la incorporación de la metodología mobile learning en educación primaria, así como la adecuación en el uso de tecnologías móviles emergentes como la realidad aumentada y realidad virtual. Por último, se discuten distintas implicaciones y recomendaciones sobre la aplicación de los dispositivos móviles en el aula, entre ellas la generalización de estos recursos en este espacio, reticencias que todavía existen por parte del personal docente (maestros y maestras) y la mejora del aprendizaje estudiantil.
Mental Health, Drug, and Violence Interventions for Sexual/Gender Minorities: A Systematic Review
Authors: Coulter Robert W. S. , Egan James E. , Kinsky Suzanne , Friedman M. Reuel , Eckstrand Kristen L. , Frankeberger Jessica , Folb Barbara L. , Mair Christina , Markovic Nina , Silvestre Anthony , Stall Ron , Miller Elizabeth 
Published: August 2019

CONTEXT:
Compared with cisgender (nontransgender), heterosexual youth, sexual and gender minority youth (SGMY) experience great inequities in substance use, mental health problems, and violence victimization, thereby making them a priority population for interventions.

OBJECTIVE:
To systematically review interventions and their effectiveness in preventing or reducing substance use, mental health problems, and violence victimization among SGMY.

DATA SOURCES:
PubMed, PsycINFO, and Education Resources Information Center.

STUDY SELECTION:
Selected studies were published from January 2000 to 2019, included randomized and nonrandomized designs with pretest and posttest data, and assessed substance use, mental health problems, or violence victimization outcomes among SGMY.

DATA EXTRACTION:
Data extracted were intervention descriptions, sample details, measurements, results, and methodologic rigor.

RESULTS:
With this review, we identified 9 interventions for mental health, 2 for substance use, and 1 for violence victimization. One SGMY-inclusive intervention examined coordinated mental health services. Five sexual minority–specific interventions included multiple state-level policy interventions, a therapist-administered family-based intervention, a computer-based intervention, and an online intervention. Three gender minority–specific interventions included transition-related gender-affirming care interventions. All interventions improved mental health outcomes, 2 reduced substance use, and 1 reduced bullying victimization. One study had strong methodologic quality, but the remaining studies’ results must be interpreted cautiously because of suboptimal methodologic quality.

LIMITATIONS:
There exists a small collection of diverse interventions for reducing substance use, mental health problems, and violence victimization among SGMY.

CONCLUSIONS:
The dearth of interventions identified in this review is likely insufficient to mitigate the substantial inequities in substance use, mental health problems, and violence among SGMY.
A glomus vagale tumorok kivizsgálása és ellátása
Authors: Iszlai Zoltán , Szövördi Éva , Karosi Tamás 
Published: August 2019

Abstract: Introducing the diagnostic protocol and therapy of a rare disease reviewing the worldwide literature named as vagal paraganglioma is our main target. This type is specific for women of middle age, and it is appearing as a unilateral neck mass, with or without Fontaine’s sign. Giving a heavy aspect on the ear, nose and throat examination, the most important diagnostic tool is CT-angiography. Carefully looking at the size and relationship with the narrowing arteries, veins, nerves, muscles and bony structures (skull base, cervical spine), in most of the cases we choose the surgical procedure. Orv Hetil. 2019; 160(34): 1358–1362.