bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technical challenges in generalizing calibration techniques for breast density measurements
Authors: Fowler Erin E. E. , Smallwood Autumn M. , Khan Nadia Z. , Kilpatrick Kaitlyn , Sellers Thomas A. , Heine John 
Published: December 2018

PurposeWe are developing a calibration methodology for full‐field digital mammography (FFDM). Calibration compensates for image acquisition technique influences on the pixel representation, ideally producing improved inter‐image breast density estimates. This approach relies on establishing references with rigid breast tissue‐equivalent phantoms (BTEs) and requires an accurate estimate of the compressed breast thickness because the system readout is nominal. There is also an attenuation mismatch between adipose breast tissue and the adipose BTE that was noted in our previous work. It is referred to as the “attenuation anomaly” and addressed in this report. The objectives are to evaluate methods to correct for the compressed breast thickness and compensate for the attenuation anomaly.MethodsThickness correction surfaces were established with a deformable phantom (DP) using both image and physical measurements for three direct x‐ray conversion FFDM units. The Cumulative Sum serial quality control procedure was established to ensure the thickness correction measurements were stable over time by imaging and calibrating DPs biweekly in lieu of physical measurements. The attenuation anomaly was addressed by evaluating adipose image regions coupled with an optimization technique to adjust the adipose calibration data. We compared calibration consistency across matched left and right cranial caudal (CC) mammographic views (n = 199) with and without corrections using Bland–Altman plots. These plots were complemented by comparing the right and left breast calibrated average (μa) and population distribution mean (ma) with 95% confidence intervals and difference distribution variances with the F‐test for uncorrected and corrected data.ResultsThickness correction surfaces were well approximated as tilted planes and were dependent upon compression force. A correction was developed for the attenuation anomaly. All paddles (large and small paddles for all units) exhibited similar tilt as a function of force. Without correction, ma = 0.92 (−1.77, 3.62) was not significantly different from zero with many negative μa samples. The thickness correction produced a significant shift in the μa distribution in the positive direction with ma = 13.99 (11.17, 16.80) and reduced the difference distribution variance significantly (P < 0.0001). Applying both corrections in tandem gave ma = 22.83 (20.32, 25.34), representing another significant positive shift in comparison with the thickness correction in isolation. Thickness corrections were stable over approximately a 2‐year timeframe for all units.ConclusionThese correction techniques are valid approaches for addressing technical problems with calibration that relies on reference phantoms. The efficacy of the calibration methodology will require validation with clinical endpoints in future studies.
Systematic review of fertility preservation patient decision aids for cancer patients
Authors: Wang Yifan , Anazodo Antoinette , Logan Shanna 
Published: December 2018

AbstractObjectiveDespite recommendations internationally for the timely provision of fertility information, cancer patients report unmet information needs, with poor provision and inadequate written information to assist in fertility preservation decision‐making. Patient decision aids (PtDAs) may be a useful resource in this setting to inform patients and guide decision‐making. A systematic review of the literature on decision aids for fertility preservation in cancer patients would determine the effectiveness of these tools in supporting decision‐making about fertility preservation and indicate their current use in clinical care.MethodsA systematic review was conducted in March 2018, within electronic search databases Medline, EMBASE, PSYCH Info, PubMed, and Web of Science. An initial search identified 718 potentially relevant articles from databases and screening of relevant reference lists.ResultsA total of 12 papers, detailing 11 studies with a total of 772 participants, evaluating nine decision aids, were included within the review. PtDAs were shown to significantly increase fertility preservation knowledge and decrease decisional conflict. Overall satisfaction with decision aids was high. Currently, only two reviewed decision aids are available for cancer patients. Another tool has been integrated into a web page, and one implementation study has been completed.ConclusionsPtDAs can serve as effective complements to current fertility counselling practices by increasing information satisfaction and decision‐making outcomes. More research is needed into the appropriateness of these resources for patients across the reproductive age range. Future implementation studies may assist in aiding dissemination of these tools into clinical practice.
Direct Synthesis of Gold Nanoparticle‐Over‐Nanosheet for Sensitive SERS Detection
Authors: Chen Yu , Shen Jin , Zhu Peng , Wang Jie , Wang Guoqi , Yuan Mengdi , Ouyang Fangping , Tong Lianming , Xiong Xiang 
Published: December 2018

AbstractA simple ethanol sol‐based method for the synthesis of gold nanosheets (AuNSs) and gold nanoparticle‐over‐nanosheet (AuNP/NS) is developed. Gold nanoparticles (AuNPs) with average sizes of ≈8 nm are grown in situ on the surface of the AuNS, which forms a NP/NS structure that obtains strong, significantly improved, surface‐enhanced Raman spectroscopy activity with the magnitude ≈2 and ≈6 orders higher than the simplex AuNP and AuNS, respectively. This performance is mainly attributed to uniform AuNPs that are closely packed over AuNS and coupled with NP–NS and NP–NP interactions. The NP–NS–GP (the gap between NP–NS) is narrower than NP–NP–GP in which much stronger and steadier plasmon resonance is obtained that can significantly enhance the Raman signal. The results show that single‐crystalline AuNS is an ideal substrate, which can be further coated with other metallic NPs to form a new flexible, high‐activity and AuNS‐based nanocomposite for a wide variety of applications.
Charge‐Induced Shifts in Chiral Surface Plasmon Modes in Gold Nanorod Assemblies
Authors: Kumar Jatish , López‐Martínez Elena , Cortajarena Aitziber L. , Solís Diego M. , Taboada José M. , Díez‐Buitrago Beatriz , Pavlov Valeri , Liz‐Marzán Luis M. 
Published: December 2018

AbstractA detailed investigation of the effect of electron injection on the chiral plasmon modes of helical nanorod assemblies is presented. An increased surface plasmon frequency of the electron gas due to the addition of electrons leads to a blue‐shift in the corresponding chiral surface plasmon modes. The mechanism behind the shift in plasmonic chirality due to nanorod charging is investigated using theoretical simulations. Charging of the nanorods alters the surface electron density, thereby modifying the plasma frequency and causing a change in the dielectric function. The nature of the plasmon shift and the intensity of chiral surface plasmons are found to be largely dependent on the extent of electron addition. At extended periods of time, the blue shifted band slowly shifts back toward the red, due to transfer of electrons back to the medium, leading to discharging of the nanorods.
Synthesis of Longer‐Wavelength‐Emissive Carbon Quantum Dots for WLEDs and Investigation of Their Photoluminescence Properties
Authors: Kumari Rinki , Kumar Sahu Sumanta 
Published: December 2018

AbstractThe synthesis of highly fluorescent longer wavelength emissive carbon quantum dots (CQDs) is still a great challenge as well as an important issue, hindering its application in white light emitting diode (WLED). Herein, we have demonstrated a simple one‐pot solvothermal route for the synthesis of nitrogen and sulphur co‐doped CQDs using pyromellitic acid (PA), diethylenetriamine (DETA) and thiourea. At the specific molar ratio of the precursors, the orange color emissive CQDs (O‐CQDs) are synthesized and possess longer wavelength emission (611 nm). Additionally, O‐CQDs exhibits temperature and pH dependent photoluminescence (PL) properties. The O‐CQDs shows color correlated temperature (CCT) of 1745 K with high color purity of 98%. Simultaneously, as‐synthesized nitrogen and sulphur co‐doped CQDs shows concentration‐dependent PL properties, which display not only the brightness with stable orange color but also possess range of multicolour emission at different PL excitation. Solid host matrix of O‐CQDs is fabricated with poly‐(methyl methacrylate) (PMMA) chloroform solution and orange emissive property is investigated by wrapping the film over LED (InGaN) bulb. These studies will open up new opportunities to explore the tunable optical properties of carbon quantum dots and its applications in WLED devices.
DBU‐Mediated Intermolecular 5‐exo‐dig Cyclization of PropargylAlcohols and Carbon Disulfide to [1,3]‐Oxathiole‐2‐thiones
Authors: Savarimuthu Sebastian Antony , Prakash Devarajan Gnanaprakasi Leo , Thomas Selvaraj Augustine , Gandhi Thirumanavelan 
Published: December 2018

Abstract5‐exo‐dig is a versatile Baldwin tool to predict and make useful heterocyclic compounds from nucleophiles and electrophiles. In order to aid this, a novel metal‐free method is proposed to produce [1,3]‐oxathiole‐2‐thiones from a readily synthesized propargyl alcohols and easily accessible carbon disulfide, where both secondary and primary propargyl alcohols are compatible to this methodology. This procedure is simple, versatile, atom economy and functional group tolerance resulting in moderate to excellent yields. Finally, the process was screened on different mode of reaction operation.
Ratiometric Fluorescence Sensing of Cu(II): Elucidation of FRET Mechanism and Bio‐Imaging Application
Authors: Sikdar Anindita , Roy Swapnadip , Mahto Ram B. , Mukhopadhyay Sudit S. , Haldar Kakali , Panja Sujit S. 
Published: December 2018

AbstractRhodamine‐formylaniline conjugateRFAhas been developed as a Cu2+‐selective ratiometric fluorescent probe. The probe shows high selectivity towards Cu2+ion through both its absorption and emission properties; and has been characterized by1H NMR, FTIR, ESI‐MS spectroscopy. Sensing of Cu2+proceed through FRET process which is nicely depicted from steady‐state and fluorescence lifetime studies. From the measurement of fluorescence lifetime, the FRET mechanism has been established undoubtedly. The important parameters regarding FRET, namely the energy transfer efficiency (ΦEt) and the Förster distance (R0) have also been calculated by fluorescence measurement. The origin of different emission bands has been distinguished by recording excitation spectra. The lowest detection limit (DL) for Cu2+ion was 4.2 ×10−7 M in Tris‐HCl buffered MeCN: H2O (10 mM, 1:1 v/v).
Decarboxylative Coupling of Cyclic α‐Amino Acid with Aldehyde and Kojic Acid: Direct Access to 2‐Pyrrolidinyl and 2‐Piperidinyl Kojic Acid Derivatives
Authors: Krishna Rao Medikonda V. , Reddy K. Nagarjuna , Sridhar B. , Subba Reddy B. V. 
Published: December 2018

AbstractA novel class of kojic acid derivatives have been synthesized by a three component decarboxylative coupling of amino acid, aldehyde and kojic acid under thermal conditions. It is an entirely new strategy for the synthesis of 2‐pyrrolidinyl and 2‐piperidinyl kojic acid derivatives.
Boosting the Stability of Perovskite Solar Cells through a Dopant‐Free Tetraphenylbenzidine‐Based Hole Transporting Material
Authors: Xiang Junyan , Liu Xicheng , Sun Mengna , Li Xianggao , Wang Shirong , Xiao Yin , Zhang Jinli , Zhang Fei 
Published: December 2018

AbstractDeveloping high‐performance hole transporting materials (HTMs) is one of the hottest topics to enhance both efficiency and stability in perovskite solar cells (PSCs). One tetraphenylbenzidine (TPB) based HTM, XY1, was designed and synthesized. XY1 exhibits suitable thermal stability, film‐forming property, and hole mobility. Notably, a power conversion efficiency (PCE) of 13.23 % under 100 mW cm−2 AM 1.5G illumination is obtained from cells by using XY1 as HTM. Moreover, the unsealed device based on XY1 maintains its initial PCE for 600 h when aged under ambient air of 40% relative humidity in the dark and dropped by 30.2% after 480 h under continuous operation at 1‐sun illumination in ambient air, respectively, which is much better than devices based on Spiro‐OMeTAD. The results demonstrate a simple molecular engineering strategy to design TPB based hole‐transporting materials for highly stable perovskite solar cells, which is important for commercial application.
A Computational Scrutiny on the Stability, Structure, and Electronic Features of Alkanesulfonate Based Zincate Salts with Varying Countercations
Authors: Singh Rohit , Singh Kaman , Pandey Sarvesh Kumar 
Published: December 2018

AbstractA systematic computational study has been carried out to investigate the effect of variation of countercations on the structures, stability, and electronic properties of six zincate salts,R2ZM[whereZM=[Zn(OSO2Me)4]2−;R=Et4N+(EZM), Et3MeN+(E3MZM), Et2Me2N+(E2 M2ZM), EtMe3N+(EM3ZM), Me4N+(MZM), and H4N+(HZM)], based on weakly‐coordinating alkanesulfonate ligand. The Computational exploration compared the binding energies (BEs), change in Gibb's free energies (▵Gform), HOMO‐LUMO energy gaps (HLEGs) and other derived parameters, using B97‐D/cc‐pVDZ level of study, to investigate the stability pattern, structures, and electronic properties of the cation‐anion set of models. The comparative analyses of model salts reveal the stability order asHZM>MZM>EM3ZM>E3MZM>E2 M2ZM>EZMon account of the involved primary and secondary interactions, BEs, and the ▵Gform. Few other important electronic parameters that are closely associated with the chemical reactivity, chemical hardness, chemical potential, and electrophilicity index are highest forHZMsalt (most stable), whereas, lowest (least reactive) value was found in case of its dipole moment. The present study on salts based on less explored weakly‐coordinating alkanesulfonate ligand would assist in predicting the rational synthesis and design of new metal‐containing salts with properties for desired applications.
Neue Lagerhalle im Kontext eines denkmalgeschützten Industrieareals – Neubau Radsatzlager des SBB‐Reparaturcenters in Zürich‐Altstetten
Authors: Haffter Andreas 
Published: December 2018

AbstractAuf dem Areal des Reparaturcenters der SBB in Zürich‐Altstetten entstand 2016–2017 eine neue Lagerhalle für Radsätze. Die eingeschossige Halle liegt in einem historischen Industrieareal und soll neben ihrer Funktionalität auch dem standortspezifischen Kontext Rechnung tragen. Die Halle weist Grundrissabmessungen von 24,1 m × 53,5 m auf. Eine kleine, an die Haupthalle angeschlossene Nebenhalle ist ebenfalls Teil des Neubauprojekts. Die Dachbinder der Haupthalle überspannen die gesamte Hallenbreite und werden an deren Längsfassade von Abfangfachwerken gestützt. Diese Strebenfachwerke spannen rd. 26,5 m weit und ruhen auf sechs bis zu 9 m hohen Ortbetonstützen. Ausgesteift wird die Halle primär über die Rahmenwirkung der in Einzelfundamenten eingespannten Ortbetonstützen. Die Fassade der unbeheizten und teilweise offenen Halle wird durch eine Schürze aus Lochblechen gebildet. Das Stahl‐ und Betontragwerk der Halle ist integraler Bestandteil der sichtbaren Fassade, eine künstlerisch gestaltete Dachlandschaft bildet einen einzigartigen Abschluss zu dessen Umgebung.
Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer's disease
Authors: Wang Guoqiao , Xiong Chengjie , McDade Eric M. , Hassenstab Jason , Aschenbrenner Andrew J. , Fagan Anne M. , Benzinger Tammie L.S. , Gordon Brian A. , Morris John C. , Li Yan , Bateman Randall J. ,   Dominantly Inherited Alzheimer Network (DIAN)
Published: December 2018

AbstractIntroductionAs the role of biomarkers is increasing in Alzheimer's disease (AD) clinical trials, it is critical to use a comprehensive temporal biomarker profile that reflects both baseline and longitudinal assessments to establish a more precise association between the change in biomarkers and change in cognition. Because age of onset of dementia symptoms is highly predictable, and there are relatively few age‐related comorbidities, the Dominantly Inherited Alzheimer Network autosomal dominant AD population affords a unique opportunity to investigate these relationships in a well‐characterized population.MethodsA novel joint statistical model was used to simultaneously evaluate how a comprehensive AD biomarker profile predicts change in cognition using amyloid positron emission tomography (PET), CSF Aβ42, CSF total tau and Ptau181, cortical metabolism using [F‐18] fluorodeoxyglucose–PET, and hippocampal volume from participants enrolled in the Dominantly Inherited Alzheimer Network (n = 262) with mean (SD) duration of follow‐up of 2.7 (1.2) years.ResultsBaseline amyloid PET levels and CSF biomarkers were associated with change in cognition in contrast to the rate of change of brain metabolism and hippocampal volume, which predicted change in cognition.ConclusionsThis study suggests that the baseline value of amyloid PET and CSF Aβ42 measures may be useful for screening participants for AD trials; however, brain hippocampus atrophy and hypometabolism are only useful as repeated longitudinal assessments for tracking cognition and disease progression. This suggests that measures of amyloid plaques predict future cognitive decline, but only longitudinal measures of neurodegeneration correlate with cognitive decline. The novel statistical model used in this study can be easily applied to any pair of outcomes and has potential to be widely used by the AD research community.
Drainage evolution in the Polish Sudeten Foreland in the context of European fluvial archives
Authors: Krzyszkowski Dariusz , Bridgland David R. , Allen Peter , Westaway Rob , Wachecka-Kotkowska Lucyna , Czerwonka Jerzy A. 
Published: December 2018

AbstractDetailed study of subsurface deposits in the Polish Sudeten Foreland, particularly with reference to provenance data, has revealed that an extensive preglacial drainage system developed there in the Pliocene–Early Pleistocene, with both similarities and differences in comparison with the present-day Odra (Oder) system. This foreland is at the northern edge of an intensely deformed upland, metamorphosed during the Variscan orogeny, with faulted horsts and grabens reactivated in the Late Cenozoic. The main arm of preglacial drainage of this area, at least until the early Middle Pleistocene, was the Palaeo–Nysa Kłodzka, precursor of the Odra left-bank tributary of that name. Significant preglacial evolution of this drainage system can be demonstrated, including incision into the landscape, prior to its disruption by glaciation in the Elsterian (Sanian) and again in the early Saalian (Odranian), which resulted in burial of the preglacial fluvial archives by glacial and fluvioglacial deposits. No later ice sheets reached the area, in which the modern drainage pattern became established, the rivers incising afresh into the landscape and forming post-Saalian terrace systems. Issues of compatibility of this record with the progressive uplift implicit in the formation of conventional terrace systems are examined, with particular reference to crustal properties, which are shown to have had an important influence on landscape and drainage evolution in the region.
Recent hydrological variability of the Moroccan Middle Atlas Mountains inferred from microscale sedimentological and geochemical analyses of lake sediments
Authors: Jouve Guillaume , Vidal Laurence , Adallal Rachid , Rhoujjati Ali , Benkaddour Abdelfattah , Chapron Emmanuel , Tachikawa Kazuyo , Bard Edouard , Courp Thierry , Dezileau Laurent , Hebert Bertil , Rapuc William , Simonneau Anaëlle , Sonzogni Corinne , Sylvestre Florence 
Published: December 2018

AbstractStudy of the hydro-sedimentary dynamics of lakes provides key information on hydrological changes. In this work, we investigate Lake Azigza in the Moroccan Middle Atlas, a region that suffers from a scarcity of observational hydrological data necessary for a coherent management of water resources. Sedimentary deposits of Lake Azigza (32°58′N, 5°26′W, 1,550 m above sea level) were dated and analyzed by combining geochemical and mineralogical measurements coupled with microfacies characterization for the last 134 yr. The detrital component derived from X-ray fluorescence elemental composition and microstructures analysis of the lake sediments provided proxies of runoff activity and lake-level changes, respectively. These proxies were calibrated with regional hydro-climatic and instrumental measurements available over the last 50 yr and used to reconstruct past hydrological changes on inter-annual to decadal time scales between 1879 and 2013. Since 1879, lake level and runoff proxies responded in phase to regional inter-annual precipitation variations. We also show that after the major lake-level drop observed in 2008, the response of the runoff proxy to variable precipitation regime is enhanced. Such an approach emphasizes the potential of these hydro-climate-sensitive sedimentary archives to assess the impact of climate change in the Mediterranean region.
Considering Age-Related Hearing Loss in Neuropsychological Practice: Findings from a Feasibility Study
Authors: Dupuis Kate , Yusupov Iris , Vandermorris Susan , Murphy Kelly L. , Rewilak Dmytro , Stokes Kathryn A. , Reed Marilyn 
Published: December 2018

RÉSUMÉLa perte auditive représente une problématique répandue chez la population âgée. Cela peut poser des défis pour les neuropsychologues, étant donné que les méthodes d’intervention doivent être présentées oralement et donc entendues avec précision. Dans cette étude, le statut auditif de 20 clients (âge moyen= 71 ans) a été évalué au sein d’une clinique de neuropsychologie en milieu hospitalier et l’impact de cette évaluation sur la pratique des neuropsychologues a été étudié. Un assistant de recherche a administré un bref test de dépistage des troubles auditifs à chacun des clients. Nous avons demandé à quatre neuropsychologues de commenter le statut auditif de leurs clients avant et après leur avoir présenté les résultats des tests de dépistage. Le dépistage a révélé que la majorité des clients présentait au moins une perte auditive légère et que les neuropsychologues étaient relativement précis (60 %) dans leur estimation du statut auditif de leurs clients. Enfin, les neuropsychologues ont utilisé l’information sur le statut auditif de leurs clients en vue de les diriger vers des services en audiologie, ainsi que pour renseigner les clients et les familles sur la perte auditive et la communication.