bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corps combattant, corps sportif, corps traumatisé
Authors: Augé Axel 
Published: November 2024

L’état de stress post-traumatique des militaires revenant des opérations extérieures de l’armée française a, depuis vingt ans, durablement marqué les combattants. Ces blessures diminuent les avoirs guerriers rendant inapte au combat le corps physique du soldat. L’armée, ses organes et les associations spécialisées dans l’accompagnement post-traumatique proposent des activités sportives pour aider le blessé à retrouver sa place dans la société militaire et civile. Or, la pratique d’un sport pour se reconstruire relève de dynamiques sociales hétérogènes. Les manières d’exercer une activité sportive font ressortir des motivations différenciées qui discriminent les militaires entre « pur utilisateur » en reconstruction physique dans un continuum thérapeutique, « ultra sportif » en quête d’adrénaline dans une morale de l’endurance et du dépassement, et « pratiquant individualiste » voulant se réaccorder avec soi dans une recherche de confiance. Basée sur une méthodologie compréhensive et qualitative, cette recherche revient sur les usages sociaux du sport dans la reconstruction post-traumatique du militaire blessé en opération.
Unsupervised learning analysis on the proteomes of Zika virus
Authors: Lara-Ramírez Edgar E. , Rivera Gildardo , Oliva-Hernández Amanda Alejandra , Bocanegra-Garcia Virgilio , López Jesús Adrián , Guo Xianwu 
Published: November 2024

Background
The Zika virus (ZIKV), which is transmitted by mosquito vectors to nonhuman primates and humans, causes devastating outbreaks in the poorest tropical regions of the world. Molecular epidemiology, supported by clustering phylogenetic gold standard studies using sequence data, has provided valuable information for tracking and controlling the spread of ZIKV. Unsupervised learning (UL), a form of machine learning algorithm, can be applied on the datasets without the need of known information for training.

Methods
In this work, unsupervised Random Forest (URF), followed by the application of dimensional reduction algorithms such as principal component analysis (PCA), Uniform Manifold Approximation and Projection (UMAP), t-distributed stochastic neighbor embedding (t-SNE), and autoencoders were used to uncover hidden patterns from polymorphic amino acid sites extracted on the proteome ZIKV multi-alignments, without the need of an underlying evolutionary model.

Results
The four UL algorithms revealed specific host and geographical clustering patterns for ZIKV. Among the four dimensionality reduction (DR) algorithms, the performance was better for UMAP. The four algorithms allowed the identification of imported viruses for specific geographical clusters. The UL dimension coordinates showed a significant correlation with phylogenetic tree branch lengths and significant phylogenetic dependence in Abouheif’s Cmean and Pagel’s Lambda tests (p value < 0.01) that showed comparable performance with the phylogenetic method. This analytical strategy was generalizable to an external large dengue type 2 dataset.

Conclusion
These UL algorithms could be practical evolutionary analytical techniques to track the dispersal of viral pathogens.
Performance Studies of Ridge Gourd (Luffa acutangula (L.) Roxb.) Genotypes for Growth and Yield Parameters
Authors: H T Amulya , K H Yashavantakumar , Hadimani H P , Chittapur Rekha Bheemappa , Ryavalad Shivayogi Y , Kavya  
Published: November 2024

Ridge gourd [Luffa acutangula (L.)] commonly known as kalitori, angled gourd, angled loofah, silky gourd and ribbed gourd, belongs to Cucurbitaceae family with chromosome number 2n = 26. The current experiment was conducted at the College of Horticulture, Bagalkot, Karnataka during the Rabi- Summer season of 2023–2024 to evaluate thirty-eight different genotypes of ridge gourd. The experiment had two replications and was set up using a randomized complete block design. Analysis of variance showed that existence of high degree of variability among the genotypes. On the basis of mean performance, Hireharukuni local performed better for parameters like vine length (501.25 cm), number of primary branches per vine (4.08), node at first female flower (7.17), days to first harvest (55.18) and yield parameters with highest yield of 3.86kg/vine.
The effect of layout and pacing on learning from diagrams with unnecessary text
Authors: Rop Gertjan , Schüler Anne , Verkoeijen Peter P.J.L. , Scheiter Katharina , Gog Tamara Van 
Published: August 2018

SummaryAlthough the presentation of extraneous (i.e., irrelevant or unnecessary) information hinders learning, it is unclear whether and how layout and pacing influence this effect. In two experiments, participants learned how the heart functions using four different layouts: a diagram presented without unnecessary text (diagram only), with unnecessary text separated from the diagram (separated) or integrated into the diagram (integrated), or with separated unnecessary text and the instruction to integrate (integration instruction). In Experiment 1, study time was self‐paced for half of the participants and system paced for the other half. There were no effects of layout and of pacing on learning, although system pacing was more effortful than self‐pacing. In Experiment 2, which was system paced and employed eye tracking, the integrated condition showed worse learning outcomes than the separated condition. Moreover, in the integrated condition, participants made more integration attempts between the unnecessary text and the diagram than in the separated condition.
Mussel‐Inspired Defect Engineering of Graphene Liquid Crystalline Fibers for Synergistic Enhancement of Mechanical Strength and Electrical Conductivity
Authors: Kim In Ho , Yun Taeyeong , Kim Jae‐Eun , Yu Hayoung , Sasikala Suchithra Padmajan , Lee Kyung Eun , Koo Sung Hwan , Hwang Hoseong , Jung Hong Ju , Park Jeong Young , Jeong Hyeon Su , Kim Sang Ouk 
Published: August 2018

AbstractInspired by mussel adhesive polydopamine (PDA), effective reinforcement of graphene‐based liquid crystalline fibers to attain high mechanical and electrical properties simultaneously is presented. The two‐step defect engineering, relying on bioinspired surface polymerization and subsequent solution infiltration of PDA, addresses the intrinsic limitation of graphene fibers arising from the folding and wrinkling of graphene layers during the fiber‐spinning process. For a clear understanding of the mechanism of PDA‐induced defect engineering, interfacial adhesion between graphene oxide sheets is straightforwardly analyzed by the atomic force microscopy pull‐off test. Subsequently, PDA could be converted into an N‐doped graphitic layer within the fiber structure by a mild thermal treatment such that mechanically strong fibers could be obtained without sacrificing electrical conductivity. Bioinspired graphene‐based fiber holds great promise for a wide range of applications, including flexible electronics, multifunctional textiles, and wearable sensors.
Functionalization of Hybrid 1D SnO2–ZnO Nanofibers for Formaldehyde Detection
Authors: Zhang Rui , Zhou Tingting , Zhang Tong 
Published: August 2018

AbstractFunctionalization of nanomaterials is widely utilized in the design of sensing layer of gas sensors, whose high sensing performances largely depend on the design of the materials component and structure. Here, an advanced 1D hierarchical nanofibers consisting of 1D backbone with well‐defined p‐type NiO nanosheets built porous shells is reported. The backbone is filled with SnO2 and ZnO nanoparticles to form a 1D heterostructure nanofiber that enables accelerated reaction rate between target gas and sensing layer. In the outer nanosheets shell of 1D hybrid nanofiber, NiO is a p‐type semiconductor with high catalytic activity to create extra rich heterocatalytic reactions active site within interface layers. Importantly, the NiO nanosheets shell exhibit a highly porous but robust architecture that could enhance the utilization ratio of the sensing layer upon target gases. Taken together, these results highlight the merits of employing novel functionalized SnO2–ZnO nanofiber as active components to achieve a high sensitivity of 12.2, excellent selectivity to formaldehyde at a low temperature range of 120–150 °C, which are superior over the SnO2 nanofiber, SnO2–ZnO nanofiber, and NiO nanosheets.
Bioinspired Microstructured Pressure Sensor Based on a Janus Graphene Film for Monitoring Vital Signs and Cardiovascular Assessment
Authors: Song Zhongqian , Li Weiyan , Bao Yu , Wang Wei , Liu Zhenbang , Han Fangjie , Han Dongxue , Niu Li 
Published: August 2018

AbstractThe rational structural design of materials is an efficient strategy for optimizing the sensing properties of pressure sensors for electronic skins. Here, inspired by the arches of the foot, a novel Janus graphene film (JGF) with concave‐convex arch‐shaped microstructures on both surfaces is presented. Then, a polymer‐substrate‐free pressure sensor with a wide sensing range, fast response time, and good stability is fabricated using a face‐to‐face assembly method. Its special microstructures can effectively hinder the full contact of two face‐to‐face JGF electrodes and lead to a tunable pressure‐dependent contact area. Subtle pressure variations can be captured due to these special arch‐shaped microstructures. Hence, the JGF‐based pressure sensor could be used to monitor the vital signs of the human body such as human‐body motion, breathing, and arterial pulse. Stable epidermal pulse wave signals are detected, and a series of indices are extracted to assess arterial stiffness and vascular aging. Thanks to its low‐cost, simplified fabrication process, the pressure sensor exhibits great potential for monitoring health in real time and screening for arteriosclerotic disease.
Anellierte Cyclobutane durch Fe‐katalysierte Cycloisomerisierung von Eninacetaten
Authors: Kramm Frederik , Teske Johannes , Ullwer Franziska , Frey Wolfgang , Plietker Bernd 
Published: August 2018

AbstractKationische Fe‐Komplexe des allgemeinen Typs [(Ph3P)2Fe(CO)(NO)]X (X=BF4, BArF4) katalyiseren die redox‐neutrale Cycloisomerisierung von 1,6‐ und 1,7‐Eninacetaten in guten Ausbeuten und Diastereoselektivitäten zu bicyclischen Cyclobutanen unter milden Bedingungen.
Stable Expanded Porphycene‐Based Diradicaloid and Tetraradicaloid
Authors: Rana Anup , Hong Yongseok , Gopalakrishna Tullimilli Y. , Phan Hoa , Herng Tun Seng , Yadav Priya , Ding Jun , Kim Dongho , Wu Jishan 
Published: August 2018

AbstractThe synthesis of a bithiophene‐bridged 34π conjugated aromatic expanded porphycene 1 and a cyclopentabithiophene bridged 32π conjugated anti‐aromatic expanded porphycene 2 by a McMurry coupling strategy is presented. Magnetic measurements and theoretical calculations reveal that both 1 and 2 exhibit an open‐shell singlet ground state with significant radical character (y0=0.63 for 1; y0=0.68, y1=0.18 for 2; y0: diradical character, y1: tetraradical character) and a small singlet–triplet energy gap (ΔES‐T=−3.25 kcal mol−1 for 1 and ΔES‐T=−0.92 kcal mol−1 for 2). Despite the open‐shell radical character, both compounds display exceptional stability under ambient air and light conditions owing to effective delocalization of unpaired electrons in the extended cyclic π‐conjugation pathway.
Struktur, Totalsynthese und Biosynthese der Chloromyxamide: Myxobakterielle Tetrapeptide mit einem ungewöhnlichen 6‐Chloromethyl‐5‐methoxypipecolinsäure‐Baustein
Authors: Gorges Jan , Panter Fabian , Kjaerulff Louise , Hoffmann Thomas , Kazmaier Uli , Müller Rolf 
Published: August 2018

AbstractBodenbakterien stellen eine wichtige Quelle zur Entdeckung neuer Naturstoffe großer struktureller Diversität dar, die die zugrundeliegenden Biosynthesewege sowie den Einbau einer Vielzahl verschiedener kleiner Molekülbaueinheiten widerspiegelt. In dieser Arbeit wird die vollständige Strukturaufklärung, Totalsynthese sowie Biosynthese der Chloromyxamide vorgestellt, einer neuen Klasse von Tetrapeptiden, die eine ungewöhnliche 6‐Chloromethyl‐5‐methoxypipecolinsäure(CMPA)‐Einheit enthalten. Die chemische Synthese, die einen synthetischen Zugang zur CMPA‐Einheit beinhaltet, wurde genutzt, um die Chloromyxamidstruktur zu verifizieren und ermöglichte die Bestimmung der Konfiguration der CMPA‐Einheit. Ein Modell der nichtribosomalen Biosynthese der Chloromyxamide wurde auf Basis der Evaluierung des Biosynthesegenclusters und aus Fütterungsexperimenten mit isotopenmarkierten Vorläufermolekülen erstellt. Dies ergab einen tiefen Einblick in die Biosynthese der verschiedenen Chloromyxamidderivate sowie in die Biogenese der CMPA‐Einheit.
Sulfur Spillover on Carbon Materials and Possible Impacts on Metal–Sulfur Batteries
Authors: Medenbach Lukas , Escher Ines , Köwitsch Nicolas , Armbrüster Marc , Zedler Linda , Dietzek Benjamin , Adelhelm Philipp 
Published: August 2018

AbstractThere is currently intense research on sulfur/carbon composite materials as positive electrodes for rechargeable batteries. Such composites are commonly prepared by ball milling or (melt/solution) impregnation to achieve intimate contact between both elements with the hope to improve battery performance. Herein, we report that sulfur shows an unexpected “spillover” effect when in contact with porous carbon materials under ambient conditions. When sulfur and porous carbon are gently mixed in a 1:1 mass ratio, complete surface coverage takes place within just a few days along with the loss of the sulfur bulk properties (crystallinity, melting point, Raman signals). Sulfur spillover also occurs in the presence of a liquid phase. Consequences of this phenomenon are discussed by considering a sodium–sulfur cell with a solid electrolyte membrane.
Structure, Total Synthesis, and Biosynthesis of Chloromyxamides: Myxobacterial Tetrapeptides Featuring an Uncommon 6‐Chloromethyl‐5‐methoxypipecolic Acid Building Block
Authors: Gorges Jan , Panter Fabian , Kjaerulff Louise , Hoffmann Thomas , Kazmaier Uli , Müller Rolf 
Published: August 2018

AbstractSoil‐living microbes are an important resource for the discovery of new natural products featuring great structural diversity that are reflective of the underlying biosynthetic pathways as well as incorporating a wide range of intriguing small‐molecule building blocks. We report here the full structural elucidation, total synthesis, and biosynthesis of chloromyxamides, a new class of tetrapeptides that display an unprecedented 6‐chloromethyl‐5‐methoxypipecolic acid (CMPA) substructure. Chemical synthesis—including an approach to access the CMPA unit—was pursued to confirm the structure of the chloromyxamides and enabled determination of the absolute configuration in the CMPA ring. A model for the nonribosomal assembly of chloromyxamides was devised on the basis of the combined evaluation of the biosynthetic gene cluster sequence and the feeding of stable isotope‐labeled precursors. This provided insight into the formation of the various chloromyxamide derivatives and the biogenesis of the CMPA unit.
Supported benzimidazole‐salen Cu(II) complex: An efficient, versatile and highly reusable nanocatalyst for one‐pot synthesis of hybrid molecules
Authors: Sharghi Hashem , Aberi Mahdi , Shiri Pezhman 
Published: August 2018

A novel and efficient nanocatalyst consisting of benzimidazole‐salen Cu(II) complex on surface‐modified silica (BS‐Cu(II)@SiO2) was prepared. The heterogeneous nanocatalyst was characterized by FESEM, TEM, EDX, FT‐IR, XRD, ICP, and TGA. The nanocatalyst was used for the one‐pot synthesis of some target hybrid molecules. An efficient four component C–H bond activation/[3 + 2] cycloaddition and condensation/cyclization/aromatization sequence toward triazole‐benzimidazole derivatives is disclosed. This methodology provides a general and rapid synthetic route to some new triazole‐benzimidazole hybrids under mild reaction conditions. In addition, the heterogeneous nanocatalyst can be easily separated from the reaction mixture and used several times without noticeable leaching or loss of its catalytic activity. We believe this interesting one‐pot reaction as well as benzimidazole‐salen Cu(II) complex pave the way to the design and synthesis of other new hybrid molecules and metal catalysts, respectively.
Preoperative oral care and effect on postoperative complications after major cancer surgery
Authors: Ishimaru M , Matsui H , Ono S , Hagiwara Y , Morita K , Yasunaga H 
Published: August 2018

Abstract

Background
Improving patients' oral hygiene is an option for preventing postoperative pneumonia that may be caused by aspiration of oral and pharyngeal secretions. Whether preoperative oral care by a dentist can decrease postoperative complications remains controversial. A retrospective cohort study was undertaken to assess the association between preoperative oral care and postoperative complications among patients who underwent major cancer surgery.

Methods
The nationwide administrative claims database in Japan was analysed. Patients were identified who underwent resection of head and neck, oesophageal, gastric, colorectal, lung or liver cancer between May 2012 and December 2015. The primary outcomes were postoperative pneumonia and all-cause mortality within 30 days of surgery. Patient background was adjusted for with inverse probability of treatment weighting using propensity scoring.

Results
Of 509 179 patients studied, 81 632 (16·0 per cent) received preoperative oral care from a dentist. A total of 15 724 patients (3·09 per cent) had postoperative pneumonia and 1734 (0·34 per cent) died within 30 days of surgery. After adjustment for potential confounding factors, preoperative oral care by a dentist was significantly associated with a decrease in postoperative pneumonia (3·28 versus 3·76 per cent; risk difference − 0·48 (95 per cent c.i. −0·64 to−0·32) per cent) and all-cause mortality within 30 days of surgery (0·30 versus 0·42 per cent; risk difference − 0·12 (−0·17 to −0·07) per cent).

Conclusion
Preoperative oral care by a dentist significantly reduced postoperative complications in patients who underwent cancer surgery.
Mechanistic Investigation into DNA Modification by a RuII,RhIII Bimetallic Complex
Authors: Rodríguez‐Corrales José Á. , Wang Jing , Winkel Brenda S. J. , Brewer Karen J. 
Published: August 2018

AbstractDespite significant progress in the treatment of cancer, there remains an urgent need for more effective therapies that also have less impact on patient wellbeing. Photodynamic therapy employs targeted light activation of a photosensitizer in selected tissues, thereby reducing off‐target toxicity. Our group previously reported a RuII,RhIII bimetallic architecture that displays multifunctional covalent photomodification of DNA in the therapeutic window in an oxygen‐independent manner, features that are essential for treating deep and hypoxic tumors. Herein, we explore the mechanism by which a new analogue, [(phen)2Ru(dpp)Rh(phen)Cl2]3+, or RuII‐RhIII, interacts with DNA. We established that RuII‐RhIII exhibits “light switch” behavior in the presence of DNA, undergoing strong electrostatic interactions that might involve groove binding. Furthermore, these noncovalent interactions play a major role in the covalent photobinding and photocleavage of DNA, which occur according to an oxygen‐independent mechanism. Polymerase chain reaction (PCR) revealed that covalent modification of DNA by RuII‐RhIII, especially photobinding, is critical to inhibiting amplification, thus suggesting that the complex could exert its toxic activity by interfering with DNA replication in cells. This new structural motif, with phenanthroline at all three terminal ligand positions, has a number of properties that are promising for the continued refinement of photodynamic‐therapy strategies.
From General to Specific: Can Pseudomonas Primary Metabolism Be Exploited for Narrow‐Spectrum Antibiotics?
Authors: Shapiro Justin A. , Kaplan Anna R. , Wuest William M. 
Published: August 2018

AbstractThe spread of antimicrobial resistance is a major threat to human health, and patients requiring prolonged antibiotic exposure are in desperate need of new therapeutic strategies. It has been hypothesized that tailoring our antibiotics to inhibit molecular targets specific to pathogens might stem the spread of resistance. A prime candidate for such a strategy is Pseudomonas aeruginosa, which can be found in the lungs of nearly all adult cystic fibrosis patients and, due to chronic exposure to antibiotics, has a high rate of multidrug‐resistant strains. Although much research has been done on P. aeruginosa virulence factors as narrow‐spectrum targets, less attention has been paid to primary carbon metabolism being leveraged for pathogen‐specific mechanisms. However, early studies show that primary metabolic pathways, although shared amongst all organisms, contain intricacies specific to Pseudomonas species that have potential for antibiotic exploitation. Here we lay out some of this work in the hopes that it inspires researchers to continue developing a knowledge base for future antibiotic discovery to build upon and include a case study of a Pseudomonas primary metabolic pathway that has been targeted by small molecules in a species‐specific manner.
Controllable Homogeneity/Heterogeneity Switch of Imidazolium Ionic Liquids for CO2 Utilization
Authors: Byun Jeehye , Zhang Kai A. I. 
Published: August 2018

AbstractImidazolium ionic liquids (IL) have been recognized as a promising platform for CO2 capture and conversion owing to the structural designability through molecular combination of cationic substituents and counter anions. However, the conventional homogeneous catalysis with ILs accompanies a laborious work‐up procedure to recycle the catalyst and purify product after the reaction, limiting the applicability of ILs. Herein, we optimize the molecular structure of imidazolium ILs to mediate the cycloaddition of CO2 upon epoxides, in which the IL functions as a homogeneous catalyst but exhibits heterogeneous separation capability. By varying the length of alkyl substituent on the imidazolium ring, the conversion efficiency of the epoxide into cyclic carbonate could be accelerated owing to higher reactivity of anions with longer aliphatic chains. The conversion efficiency was further optimized by having a proper type of counter anions with suitable level of nucleophilicity. The long‐chain IL exhibited temperature‐responsive phase transition behavior, allowing a facile isolation of IL and products after the reaction. In addition, with the high purity of obtained cyclic carbonates, non‐isocyanate poly(hydroxylurethane)s could be produced by polyaddition of diamines, promoting the utilization of CO2 as a chemical building block.