bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the Accuracy of Papanicolaou Test Cytology, Visual Inspection With Acetic Acid, and Visual Inspection With Lugol Iodine in Screening for Cervical Neoplasia in Southeast Nigeria
Authors: Egede John , Ajah Leonard , Ibekwe Perpetus , Agwu Uzoma , Nwizu Emmanuel , Iyare Festus 
Published: February 2018

Purpose This study aimed to compare the accuracy of Papanicolaou test cytology, visual inspection with 5% acetic acid (VIA), and visual inspection with Lugol iodine (VILI) in the detection of premalignant and malignant lesions of the cervix. Materials and Methods This was a cross-sectional comparative study of 200 consenting participants at the Federal Teaching Hospital, Abakaliki over a 6-month period. All the participants had Papanicolaou test cytology. Subsequently, they were classified into two groups of 100 each through systematic random sampling: group 1 had VIA and group 2 had VILI. Thereafter, all the participants had cervical punch biopsy at the 6 and 12 o’clock cervical positions. Cervical punch biopsy was also done on the suspicious lesions of the cervix irrespective of their positions. The tests of validity of the three methods were calculated using the histology of the biopsy specimen as the gold standard. P value ≤ .05 was considered to be statistically significant. Results Among the VIA group, 19 (19%) had cervical epithelial abnormalities on Papanicolaou test cytology, and VIA was positive in 14 (14%). Histology results showed cervical neoplasia in 15 (15%) of the participants. Among the VILI group, 15 (15%) had cervical epithelial abnormalities on Papanicolaou test cytology, and VILI was positive in 19 (19%). Histology results showed cervical neoplasia in 15 (15%) of the participants. There was no significant difference in overall accuracy of Papanicolaou test cytology, VIA, and VILI. The overall accuracy of the Papanicolaou test cytology plus VIA was significantly more than Papanicolaou test cytology alone. Conclusion VIA or VILI can be used as a stand-alone cervical cancer screening test when compared with Papanicolaou test cytology, particularly in resource-limited settings. VIA can also complement Papanicolaou test cytology.
Cytokinin signaling in plant development
Authors: Kieber Joseph J. , Schaller G. Eric 
Published: February 2018

ABSTRACT
The phytohormone cytokinin plays diverse roles in plant development, influencing many agriculturally important processes, including growth, nutrient responses and the response to biotic and abiotic stresses. Cytokinin levels in plants are regulated by biosynthesis and inactivation pathways. Cytokinins are perceived by membrane-localized histidine-kinase receptors and are transduced through a His-Asp phosphorelay to activate a family of transcription factors in the nucleus. Here, and in the accompanying poster, we summarize the current understanding of cytokinin metabolism, transport and signaling, and discuss how this phytohormone regulates changes in gene expression to mediate its pleiotropic effects.
Alternative miRNAs? Human sequences misidentified as plant miRNAs in plant studies and in human plasma
Authors: Witwer Kenneth W. 
Published: February 2018

Background: A 2017 study reported that “Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi”. Analysis of two human blood plasma sequencing datasets was said to provide evidence for uptake of plant miRNAs into human plasma. The results were also purportedly inconsistent with contamination. Methods: Sequences from public datasets and miRNA databases were compared with results downloaded from the website of the reporting journal. Results: Only one putative plant miRNA (“peu-MIR2910) mapped consistently above background, and this sequence is found with 100% identity in a human rRNA. Several other rarer but consistently mapped putative plant miRNAs also have 100% or near 100% matches to human transcripts or genomic sequences, and some do not appear to map to plant genomes at all. Conclusions: Reanalysis of public data suggests that dietary plant xenomiR uptake is not supported, but instead confirms previous findings that detection of rare plant miRNAs in mammalian sequencing datasets is artifactual. Some putative plant miRNAs, including MIR2910 and MIR2911, may represent human sequence contamination or other artifacts in plant studies, emphasizing the need for rigorous controls and data filtering strategies when assessing possible xenomiRNAs.
Embedding a user-centred approach in the development of complex behaviour change intervention to improve outcomes for young adults living with type 1 diabetes: The D1 Now Study
Authors: Walsh Deirdre M.J. , Hynes Lisa , O'Hara Mary Clare , McSharry Jenny ,   D1 Now Young Adult Panel, Dinneen Séan F. , Byrne Molly 
Published: February 2018

Background: Type 1 diabetes (T1D) is an auto-immune condition which requires intensive self-management. Diabetes self-management is challenging, especially during young adulthood. Effective interventions to improve outcomes for young adults with T1D are needed. This paper describes the development of the D1 Now intervention, employing a user-centred approach to engage with stakeholders in parallel with the application of theory. Methods: Intervention development consisted of 4 phases: 1) the formation of a public and patient involvement (PPI) Young Adult Panel (YAP); 2) a systematic review to synthesise evidence regarding the effectiveness of interventions aimed at improving outcomes for young adults with T1D; 3) understand young adults’ diabetes self-management behaviour through engagement with key stakeholders; and 4) an expert consensus meeting to discuss self-management strategies identified in Phase 1 and 3 that would form the core components of the D1 Now intervention. Results: The YAP resulted in meaningful involvement between young adults, researchers and service providers. The systematic review highlighted a lack of quality intervention studies. Qualitative findings highlighted how young adult self-management is driven by complex interactions between external resources, which influence capability, and motivation. The expert panel in Phase 4 highlighted focus areas to improve outcomes for young adults and implementation strategies. Subsequent to these 4 phases, 3 intervention components have been identified: 1) a key worker to liaise with the young adult; 2) an online portal to facilitate relationship building between staff and young adults; and 3) an agenda setting tool to facilitate joint decision-making. Conclusions: This study described the systematic development of an intervention underpinned by theoretical frameworks and PPI, and has identified components for the D1 Now intervention. The resulting intervention content will now be subject to an intervention optimisation process.
Stock Market Predictability and Industrial Metal Returns
Authors: Jacobsen Ben , Marshall Ben R. , Visaltanachoti Nuttawat 
Published: February 2018

Price movements in industrial metals such as copper and aluminum predict stock returns. Increasing industrial metal prices are good news for equity markets in recessions and bad news in expansions. A one-standard-deviation increase in industrial metal returns predicts a price drop of one and a half percent in monthly stock market returns in expansions and an increase of around a half percent during recessions. The predictability is distinct to and compares favorably with that from more established predictors. This paper was accepted by Lauren Cohen, finance.
Reverse total shoulder arthroplasty
Authors: Familiari Filippo , Rojas Jorge , Nedim Doral Mahmut , Huri Gazi , McFarland Edward G. 
Published: February 2018

Since the introduction of reverse total shoulder arthroplasty (RTSA) in 1987 (in Europe) and 2004 (in the United States), the number of RTSAs performed annually has increased. Although the main indication for RTSA has been rotator cuff tears, indications have expanded to include several shoulder conditions, many of which involve dysfunction of the rotator cuff. RTSA complications have been reported to affect 19% to 68% of patients and include acromial fracture, haematoma, infection, instability, mechanical baseplate failure, neurological injury, periprosthetic fracture and scapular notching. Current controversies in RTSA include optimal baseplate positioning, humeral neck-shaft angle (135° versus 155°), glenosphere placement (medial, lateral or bony increased offset RTSA) and subscapularis repair. Improvements in prosthesis design, surgeon experience and clinical results will need to occur to optimize this treatment for many shoulder conditions. Cite this article: EFORT Open Rev 2018;3:58–69 DOI: 10.1302/2058-5241.3.170044
Metaphorical and metonymical equality: From a rhetoric of society to an aesthetics of politics
Authors: Benčin Rok 
Published: February 2018

Abstract
The notion of the division of the sensible allows Jacques Rancière to suspend and redraw the lines between the politics of aesthetics and the aesthetics of politics, as well as between forms of political and aesthetic equality. The essay discusses Rancière’s work from a different angle, namely the distinction of two rhetorical figures, metaphor and metonymy, following Ernesto Laclau’s use of Gérard Genette’s reading of Proust as a model for his political theory. Outlining Rancière’s own use of the two figures as political models as well as his readings of Proust, the essay traces the differences between the rhetoric of society (Laclau) and the aesthetics of politics (Rancière).
The refugee issue at the heart of political film
Authors: Šprah Andrej 
Published: February 2018

Abstract
The article addresses the issue of the refugee crisis through the perspective of the film opus of Portuguese director Pedro Costa and especially French documentarist Sylvain George in the light of Rancière’s analyses of their works. It focuses on the radical actions of depersonalization by which refugees revolt against the intolerable regulations of the migrant and asylum policy of the European Community. It draws from the analysis of the dialogue between Rancière and George to point out aspects of political film that strive to let individuals who are excluded from economic and social trajectories take charge of their own destinies: to reclaim the possibility of their own voice and a common space. This process of transcending the intolerable is established in the relationship between politics and aesthetics, which is simultaneously the relationship between the forms of (self-) articulation of the underprivileged and the form of art utilized by the filmmaker.
Novel Scoring System for Prediction of Cardiac Syndrome X in Women with Typical Angina and a Positive Exercise Tolerance Test
Authors: Masoudkabir Farzad , Vasheghani-Farahani Ali , Hakki Elham , Poorhosseini Hamidreza , Sadeghian Saeed , Abbasi Seyed Hesameddin , Bahmanyar Shahram , Kassaian Seyed Ebrahim 
Published: February 2018

A major diagnostic challenge for cardiologists is to distinguish cardiac syndrome X (CSX) from obstructive coronary artery disease in women with typical angina and a positive exercise tolerance test (ETT). We performed this study to develop a scoring system that more accurately predicts CSX in this patient population.
Data on 976 women with typical angina and a positive ETT who underwent coronary angiography at our center were randomly divided into derivation and validation datasets. We developed a backward stepwise logistic regression model that predicted the presence of CSX, and a scoring system was derived from it.
The derivation dataset (809 patients) was calibrated by uing a Hosmer-Lemeshow goodness-of-fit test (8 degrees of freedom; χ2=12.9; P=0.115), and the area under the curve was 0.758. The validation dataset (167 patients) was calibrated in the same way (8 degrees of freedom; χ2=9.0; P=0.339), and the area under the curve was 0.782. Independent predictors of CSX were age <55 years; negative histories of smoking, diabetes mellitus, hyperlipidemia, hypertension, or familial premature coronary artery disease; and highly positive ETTs. A total score >9.5 was the optimal cutoff point for differentiating CSX from obstructive coronary artery disease.
Our proposed scoring system is a simple, objective, and accurate system for distinguishing CSX from obstructive coronary artery disease in women with typical angina and positive ETTs. It may help determine which of these patients need invasive coronary angiograms or noninvasive tests like computed tomographic coronary angiography.
Atrial Septal Defect as Unexpected Cause of Pulmonary Artery Hypertension
Authors: Parikh Rushi V. , Boyd Jack , Lee David P. , Witteles Ronald 
Published: February 2018

Methamphetamine abuse is an increasingly prevalent cause of pulmonary artery hypertension in the United States. Conversely, an atrial septal defect rarely presents late as pulmonary artery hypertension.
We present the case of a 44-year-old methamphetamine abuser who had a 3-month history of worsening fatigue and near-syncope. She had elevated cardiac enzyme levels and right-sided heart strain. Angiographic findings suggested methamphetamine-induced pulmonary artery hypertension; however, we later heard S2 irregularities that raised suspicion of an atrial septal defect. Ultimately, the diagnosis was pulmonary artery hypertension and a large secundum atrial septal defect with left-to-right flow. One year after defect closure, the patient was asymptomatic.
In addition to discussing this unexpected case of a secundum atrial septal defect masquerading as methamphetamine-induced pulmonary artery hypertension, we briefly review the natural history of atrial septal defects and emphasize the importance of thorough examination in avoiding diagnostic anchoring bias.
Cardiac Rehabilitation Improves Cardiometabolic Health in Young Patients with Nonischemic Dilated Cardiomyopathy
Authors: Wittekind Samuel G. , Gerdes Yvette , Mays Wayne , Chin Clifford , Jefferies John L. 
Published: February 2018

Nonischemic dilated cardiomyopathy is deadly and costly, and treatment options are limited. Cardiac rehabilitation has proved safe and beneficial for adults with various types of heart failure. Therefore, we retrospectively evaluated the hypothesis that rehabilitation is safe and improves cardiometabolic health in young patients with nonischemic dilated cardiomypathy.
From 2011 through 2015, 8 patients (4 males) (mean age, 20.6 ± 6.6 yr; range, 10–31 yr) underwent rehabilitation at our institution. They were in American Heart Association class C or D heart failure and were on maximal medical therapy. Their mean left ventricular ejection fraction at baseline was 0.26 ± 0.15. Two patients had a left ventricular assist device, and 2 were inpatients. To evaluate safety, we documented adverse events during rehabilitation sessions. Clinical endpoints were measured at baseline, immediately after completing rehabilitation, and after one year.
Patients attended 120 of 141 possible sessions (85%), with no adverse events. There were no marked changes in mean left ventricular ejection fraction or body mass index. The patients' mean waist circumference decreased by 1.37 ± 0.6 in (n=5; 95% CI, −2.1 to −0.63). Their 6-minute walk distance increased by a mean of 111 ± 75 m (n=5; 95% CI, 18–205).
In our small sample of young patients with nonischemic dilated cardiomyopathy, cardiac rehabilitation was feasible and was associated with minimal risk. Our findings suggest that prospective studies in this population are warranted.
Long-term recording performance and biocompatibility of chronically implanted cylindrically-shaped, polymer-based neural interfaces
Authors: Fiáth Richárd , Hofer Katharina T. , Csikós Vivien , Horváth Domonkos , Nánási Tibor , Tóth Kinga , Pothof Frederick , Böhler Christian , Asplund Maria , Ruther Patrick , Ulbert István 
Published: February 2018

AbstractStereo-electroencephalography depth electrodes, regularly implanted into drug-resistant patients with focal epilepsy to localize the epileptic focus, have a low channel count (6–12 macro- or microelectrodes), limited spatial resolution (0.5–1 cm) and large contact area of the recording sites (~mm2). Thus, they are not suited for high-density local field potential and multiunit recordings. In this paper, we evaluated the long-term electrophysiological recording performance and histocompatibility of a neural interface consisting of 32 microelectrodes providing a physical shape similar to clinical devices. The cylindrically-shaped depth probes made of polyimide (PI) were chronically implanted for 13 weeks into the brain of rats, while cortical or thalamic activity (local field potentials, single-unit and multi-unit activity) was recorded regularly to monitor the temporal change of several features of the electrophysiological performance. To examine the tissue reaction around the probe, neuron-selective and astroglia-selective immunostaining methods were applied. Stable single-unit and multi-unit activity were recorded for several weeks with the implanted depth probes and a weak or moderate tissue reaction was found around the probe track. Our data on biocompatibility presented here andin vivoexperiments in non-human primates provide a strong indication that this type of neural probe can be applied in stereo-electroencephalography recordings of up to 2 weeks in humans targeting the localization of epileptic foci providing an increased spatial resolution and the ability to monitor local field potentials and neuronal spiking activity.
Synthesis and antiproliferative activity of flavonoid triazolyl glycosides
Authors: Wang Gang-qiang , Yan Li-li , Wang Qiu-an 
Published: February 2018

Abstract
Sixteen flavonoid triazolyl glycosides 4–19 were synthesized in good yields via Cu(I)-catalyzed azide-alkyne cycloadditions of terminal alkynes of flavonoids 1–3 with acetylated sugar azides followed by deacetylation with sodium methoxide in anhydrous methanol. The antiproliferative activity of the synthesized compounds against three human cancer cell lines (Hela, HCC1954 and SK-OV-3) in vitro was evaluated. Flavonoids 1, 2 and flavonoid triazolyl glycosides 7, 12, 17 exhibit potent antiproliferative activity against these cancer cell lines.
The effect of high voltage electrostatic field (HVEF) treatment on bonding interphase characteristics among different wood sections of Masson pine (Pinus massoniana Lamb.)
Authors: He Qian , Zhan Tianyi , Zhang Haiyang , Ju Zehui , Dai Chunping , Lu Xiaoning 
Published: February 2018

Abstract
High voltage electrostatic field (HVEF) treatment has been investigated as an optimization method for enhancing the bonding performance of wood via increasing its polarization degree and improvement of the penetration of phenol formaldehyde (PF) adhesive. As the wood surfaces from cross cut (C), radial cut (R) and tangential cut (T) behave differently, five cut combinations formed the samples to be tested, namely C-C, R-R, R-T, T-T (always parallel to grain) and T-T⊥, where the grains were perpendicular to each other. The gluing and HVEF treatments were performed simultaneously. The sample surfaces were characterized by electron spin resonance (ESR) spectroscopy, dynamic contact angle (CAdyn) measurements, X-ray densitometry, fluorescence microscopy, Fourier-transform infrared (FTIR) spectroscopy and measurements of compression shear bonding strength (CSBS). An increased surface energy led to decreased CAdynS in the following order: cross section<tangential section<radial section. Obviously, the triggered free electrons of the HVEF treatments changed the wood surfaces. The penetration depth of PF into wood cell decreased significantly and the maximal density increased after the HVEF treatment. The lower CAdyns also contributed to the better reaction of the wood surface with the PF resin. The CSBS of the five sample combinations was enhanced owing to a better performance of adhesive aggregation, which was increased by 18% (C-C), 24% (T-T), 26% (T-T⊥), 31% (R-T) and 42% (R-R), respectively. Pore size and pore size distribution contributed a lot to the bonding properties of HVEF-treated wood sections.
Aromatase in normal and diseased liver
Authors: Murakami Keigo , Hata Shuko , Miki Yasuhiro , Sasano Hironobu 
Published: February 2018

Abstract

Background
A potential correlation between sex hormones, such as androgens and estrogens, and the development and progression of hepatocellular carcinoma (HCC) has been proposed. However, its details, in particular, aromatase status in diseased human liver has remained largely unknown.

Materials and methods
We immunolocalized aromatase, 17β-hydroxysteroid dehydrogenase (17β-HSD) type 1 and 17β-HSD type 2 in a total of 155 cases, consisting of normal liver (n = 10), nonalcoholic steatohepatitis (NASH) (n = 18), primary sclerosing cholangitis (PSC) (n = 6), primary biliary cholangitis (PBC) (n = 13), biliary atresia (n = 18), alcoholic hepatitis (n = 11), hepatitis C virus (HCV) (n = 31), HCV sustained virologic response (HCV-SVR) (n = 10), hepatitis B virus (HBV) (n = 20), HBV sustained virologic response (HBV-SVR) (n = 8) and infants (n = 10).

Results
Immunoreactivity scores of aromatase in HBV (59.5 ± 30.9), HBV-SVR (68.1 ± 33.5) and infants (100.5 ± 36.6) were significantly higher than those in normal liver (26.0 ± 17.1). Scores of 17β-HSD type 1 in any etiology other than HBV (116.3 ± 23.7) and infants (120.0 ± 28.5) were significantly lower than those in normal liver (122.5 ± 8.6). Scores of 17β-HSD type 2 in NASH (74.4 ± 36.6) were significantly lower than those in normal liver (128.0 ± 29.7).

Conclusion
High immunoreactivity scores of aromatase and 17β-HSD type 1 in the patients with HBV suggest a correlation between HBV infection and in situ estrogen synthesis in hepatocytes.
Design and implementation of a platform for the citizen science project migraine radar
Authors: Wogenstein Florian , Gaul Charly , Kropp Peter , Scheidt Jörg , Siebenhaar Yannic , Drescher Johannes 
Published: February 2018

Abstract
In this paper we introduce the design and technical implementation of the citizen science project Migraine Radar. The goal of the project is to establish a large collection of migraine attack data in order to explore the trigger factors of migraine attacks. A main focus is the investigation of the influence of environmental factors like weather or changes in the geomagnetic activity on the frequency of migraine attacks.
After registering with the project, participants report their migraine attack data using a web app or one of the smartphone apps implemented for Android and iOS. As a benefit, the system serves as a personal headache calendar and participants have access to statistics and individualized reports about their attacks.
For scientific analysis the data are pre-processed and provided to the researchers in an anonymized way.
Mobile learning in environmental citizen science: An initial survey of current practice in Germany
Authors: Sturm Ulrike , Moormann Alexandra , Faber Astrid 
Published: February 2018

Abstract
Citizen science is a growing approach in science and the opportunities of new technologies and learning are considered more and more. We give an overview of the current practice of mobile learning in Germany by conducting an explorative survey among environmental citizen science projects using mobile apps. This study supports the idea that education is relevant in citizen science, and apps affect the learning experience of participants. However, several obstacles were identified that need to be considered, to be able to fully exploit the benefits of mobile learning in citizen science.