bluuebunny/crossref_metadata_2025_split huggingface dataset:
A dinâmica Panhi dos temas contextuais
Authors: Apinajé Sheila Baxy Pereira de Castro 
Published: August 2019

Este texto busca apresentar alguns estágios docência (1, 2 e 3), realizados na Escola EstadualIndígena Tekator, aldeia Mariazinha e na Escola Estadual Indígena Pepkror, aldeia Boutica,Território Apinajé. Estas atividades têm relação direta com a proposta do Núcleo Takinahaky de Formação Superior Indígena (NTFSI), que busca se apropriar e experimentar o uso dos temas contextuais (TC) para uma reformulação radical de nossas matrizes curriculares colonialistas. Foco-me em mostrar como a problematização é fundamental para o desenvolvimento dos TCs, como a articulação entre atividades de problematização, atividades práticas e atividades comunitárias potencializam as aulas e como, claramente, passo a compreender melhor, ao longo dos estágios, a importância do fluxo de tempo para a prática deum saber transdisciplinar.
Relação entre o potencial esportivo de jovens alunos-atletas e coping
Authors: Sobreira Diana Izaias , Werneck Francisco Zacaron , Coelho Emerson Filipino , Simim Mário Antônio de Moura , Penna Eduardo Macedo , Miranda Luciano , Ferreira Renato Melo 
Published: August 2019

O objetivo foi analisar as diferenças nas habilidades de coping entre alunos-atletas de um Colégio Militar em função do sexo e do seu potencial esportivo avaliado pelo treinador. 385 alunos-atletas, de ambos os sexos (11 a 18 anos) responderam o Athletic Coping Skills Inventory-28, versão em português. O potencial esportivo foi quantificado a partir da expectativa que os treinadores depositavam em cada um dos alunos-atletas, em escala de 1 a 5, onde notas ≤ 3 os classificam como baixo potencial e notas 4 e 5, alto potencial. Verificamos que alunos-atletas de alto potencial apresentam escores maiores em todas as subescalas, indicando melhor gestão do estresse. Conclui-se que as habilidades psicológicas podem ser fator discriminante do potencial esportivo de jovens alunos-atletas.
Atributos de fertilidade dos solos as margens do Rio Paraguai, Pantanal de Cáceres/MT
Authors: Rocha Geilson Xavier , Pierangeli Maria Aparecida Pereira , Marques Mayara Cristina Santos 
Published: August 2019

A natureza do material de origem e os processos de deposição/sedimentação, decorrente do ciclo natural de inundação e seca, conferem aos solos do Pantanal características diferenciadas. O objetivo deste trabalho foi avaliar os atributos de fertilidade em áreas de vegetação nativa as margens do rio Paraguai, Pantanal de Cáceres – Mato Grosso. Foram coletadas amostras de solos deformadas na profundidade de 0,0 a 0,20 m para análises química e granulométrica, e amostras indeformadas na profundidade de 0,0 a 0,10 m para análise da densidade do solo (Ds), em doze áreas entre o município de Cáceres-MT e a Estação Ecológica de Taiamã, apresentando as seguintes classes de solo: Argissolo, Gleissolo, Neossolo e Planossolo. As análises químicas de fertilidade dos solos foram realizadas em todas as amostras coletadas, constando: pH em H2O, pH SMP, teores de P, K+, Ca2+, Mg2+, acidez trocável (Al3+), acidez potencial (H+Al) e matéria orgânica (M.O), sendo calculado a soma de bases (SB), a capacidade de troca de cátions (CTC pH 7,0 e CTC efetiva), a saturação por bases do solo (V) e a saturação por alumínio (m). Na análise física, foram determinadas a granulometria e a densidade do solo (Ds). Através da análise de regressão foram estabelecidas equações entre a acidez potencial (H+Al) determinada por acetato de cálcio tamponado a pH 7,0 e os valores do pH SMP visando obter uma equação que melhor descreva a relação entre essas duas variáveis, para estimar a acidez potencial. Entre as áreas amostradas, a área com presença de Neossolo apresentou as melhores características em relação a fertilidade natural do solo, entretanto a elevada acidez trocável foi verificada na maioria dos solos, pode causar restrições ao crescimento e desenvolvimento das plantas nas margens do rio Paraguai. A acidez potencial desses solos poderá ser estimada pelo método do pH SMP através da equação H + Al = 24,1861 - 3,3144 x pH SMP.
Plasma‐activated media selectively induces apoptotic death via an orchestrated oxidative stress pathway in high‐grade serous ovarian cancer cells
Authors: Davies Lorena T. , Ganesen Raja , Toubia John , Hong Sung‐Ha , Kumar KC Sushil , Oehler Martin K. , Ricciardelli Carmela , Szili Endre J. , Robinson Nirmal , Pitman Melissa R. 
Published: December 2024

High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer. Due to a lack of an early detection test and overt symptoms, many patients are diagnosed at a late stage where metastasis makes treatment very challenging. Furthermore, the current standard treatment for HGSOC patients, consisting of debulking surgery and platinum‐taxane chemotherapy, reduces quality of life due to debilitating side‐effects. Sadly, 80–90% of patients diagnosed with advanced stage ovarian cancer will die due to treatment resistance. As such, novel therapeutic strategies for HGSOC that are both more effective and less toxic are urgently required. Here we describe the assessment of cold atmospheric pressure (CAP) gas discharge technology as a novel treatment strategy in pre‐clinical models of HGSOC. Plasma‐activated media (PAM) was generated using cell growth media. HGSOC cell lines, patient ascites cells and primary tissue explants were tested for their response to PAM via analysis of cell viability, cell death and oxidative stress assays. Our data show that PAM treatment can be more effective than standard carboplatin chemotherapy at selectively targeting ovarian cancer cells in primary patient samples. Further, we also observed PAM to induce apoptosis in HGSOC cancer cell lines via induction of oxidative stress and mitochondrial‐mediated apoptosis. These findings suggest that PAM is a viable therapeutic strategy to test in in vivo models of ovarian cancer, with a view to develop an intraperitoneal PAM‐based therapy for HGSOC patients. Our studies validate the ability of PAM to selectively target tumour tissue and ascites cells. This work supports the development of PAM towards in vivo validation and translation into clinical practice.
Modified Oxygen Metabolism Toward “Sunlight‐Friendly” Photodynamic Therapy
Authors: Zhang Haiyang , Li Jipeng , Li Yongqiang , Tan Kexin , Wang Hang , Yang Muyue , Ju Yahan , Liu Yan , Wang Gang , Song Xuefei , Gu Ping , Xie Xiaoming , Yang Siwei , Ding Guqiao , Zhou Huifang , Fan Xianqun 
Published: December 2024

AbstractPhototoxicity poses a substantial challenge in photodynamic therapy, resulting in intolerable skin damage, visual impairment, and reduced quality of life. Current coping strategies, primarily focus on avoiding inappropriate photoactivation and developing targeted photosensitizers, have not effectively addressed this problem. Hence, this study aims to develop a “sunlight‐friendly” photodynamic therapy strategy. Here, 1‐methoxyphenazine methosulfate (MPMS) is innovatively identified as a key substance in achieving modified oxygen metabolism. MPMS demonstrates efficient catalytic shuttling under abnormal intracellular H2O2 levels, introducing a novel protective approach for oxygen metabolism and numerous life processes. By controlling MPMS administration, the switch of the photosensitizer states between “ON” (killing tumor cells) and “OFF” (safeguarding normal cells) can be achieved. This approach effectively mitigated phototoxicity and holds the potential for widespread clinical application.
3D Printing and Biocementation of Hierarchical Porous Ceramics
Authors: Dutto Alessandro , Bianda Eleonora , Melo Joshua G. , Saraw Zoubeir , Tervoort Elena , Studart André R. 
Published: December 2024

AbstractCeramics with controlled porosity are used as bio‐scaffolds, insulators, electrodes and lightweight materials. While their high surface area and low weight are attractive functionalities, such porous ceramics often suffer from poor mechanical properties and need energy‐intensive, high‐temperature sintering for manufacturing. The present work reports a low‐temperature approach for the manufacturing of mechanically efficient porous ceramics. The process relies on the 3D printing of inks loaded with ceramic hollow spheres, which are biocemented by the precipitation of calcium carbonate induced by ureolytic bacteria. Electron microscopy, thermogravimetric analysis and mechanical tests are performed to study the kinetics of the biocementation process and its effect on the calcification and mechanical properties of extruded and printed samples. Hierarchical porous ceramics with a grid‐like architecture and filament sizes in the order of one millimeter are effectively biocemented at ambient temperature after 2 days of calcification. The calcified structures display higher mechanical efficiency than previously reported monoliths of comparable porosity, thus demonstrating the potential of 3D printing and bacteria‐driven biocementation for the low‐temperature fabrication of hierarchical porous ceramics.
Profiling Pro‐Inflammatory Proteases as Biomolecular Signatures of Material‐Induced Subcutaneous Host Response in Immuno‐Competent Mice
Authors: Tran Nam M.P. , Truong Anh T.H. , Nguyen Dang T. , Dang Tram T. 
Published: December 2024

AbstractProteases are important modulators of inflammation, but they remain understudied in material‐induced immune response, which is critical to clinical success of biomedical implants. Herein, molecular expression and proteolytic activity of three distinct proteases, namely neutrophil elastase, matrix metalloproteinases, cysteine cathepsins (cathepsin‐K and cathepsin‐B) are comprehensively profiled, in the subcutaneous host response of immuno‐competent mice against different biomaterial implants. Quantitative non‐invasive monitoring with activatable fluorescent probes reveals that different microparticulate materials induce distinct levels of protease activity with degradable poly(lactic‐co‐glycolic) acid inducing the strongest signal compared to nondegradable materials such as polystyrene and silica oxide. Furthermore, protein expression of selected proteases, attributable to both their inactive and active forms, notably deviates from their activities associated only with their active forms. Protease activity exhibits positive correlations with protein expression of pro‐inflammatory cytokines tumor necrosis factor α and interleukin 6 but negative correlation with pro‐fibrotic cytokine transforming growth factor β1. This study also demonstrates the predictive utility of protease activity as a non‐invasive, pro‐inflammatory parameter for evaluation of the anti‐inflammatory effects of model bioactive compounds on material‐induced host response. Overall, the findings provide new insights into protease presence in material‐induced immune responses, facilitating future biomaterial assessment to evoke appropriate host responses for implant applications.
Immune Dysregulation in a Child With SOD1‐Related Neurological Disease
Authors: Boutin Rozlyn Claire Thomas , Shobeirian Farzaneh , Adam Shelin , Lehman Anna , Salvarinova Ramona , Friedman Jan M 
Published: December 2024

ABSTRACTSpastic tetraplegia and axial hypotonia (STAHP) associated with biallelic SOD1 deficiency is a recently described neurological disorder affecting children. Five studies have described a total of nine cases thus far, all characterized by the onset of progressive spastic tetraplegia beginning before 2 years of age. All but two of these cases are associated with homozygosity for the same genetic variant (NM_000454.4:c.335dupG; NP_000445.1:p.Cys112Trpfs*11) that leads to a non‐functional enzyme product. More recently, a homozygous 3‐base pair in‐frame deletion (NM_000454.5: c.357_357+2delGGT) and a truncating frameshift variant (NM_000454.5: c.52_56del5ins154) in SOD1 have been described in similarly affected patients lacking SOD1 activity. Here we expand on the neurological and extra‐neuronal phenotypes of STAHP in a patient with a novel homozygous SOD1 variant predicted to result in disrupted calcium‐ and zinc‐binding activity of the encoded enzyme. We describe a 19‐year‐old male born to consanguineous parents who is homozygous for an NM_000454.4:c.369_371del SOD1 variant. The patient had progressive neuromuscular degeneration with onset before 1 year of age, consistent with a diagnosis of STAHP. Brain MRI at 7 years of age showed cerebellar atrophy, as has previously been described in this condition, as well as small optic nerves and a hypoplastic optic chiasm, which have not been reported previously. Our patient also exhibited clinical features of immune dysregulation with treatment‐refractory inflammatory bowel disease, asthma, recurrent infections, and dermatitis. Overall, the early‐onset progressive neurological disorder in our patient, found in association with homozygosity for an SOD1 variant that is predicted to result in impaired function of the transcribed protein, is consistent with a diagnosis of STAHP. Our patient also demonstrates optic atrophy and disrupted immune homeostasis, which have not been previously described as part of this condition. Taken together with previous case studies in children carrying loss‐of‐function variants of SOD1, this case highlights a possible role for antioxidant therapy in slowing disease progression in patients lacking SOD1 activity. These cases also draw attention to the need for careful consideration of possible harmful neuronal and extra‐neuronal complications of proposed SOD1 knockdown therapies against ALS.
Telehealth Is Effective in the Evaluation of Individuals With Undiagnosed Rare Disorders: An Undiagnosed Diseases Network Study
Authors: Tan Queenie K.‐G. , McConkie‐Rosell Allyn , Mahoney Rachel , Spillmann Rebecca C. , Schoch Kelly , Chanprasert Sirisak , Acosta Maria T. , Toro Camilo , Rosenfeld Jill A. , Orengo James P. , Scott Daryl A. , Granadillo Jorge L. , Sisco Kathleen , Wegner Daniel J. , Tekin Mustafa , Bivona Stephanie , Peart LéShon , Rodan Lance , Bonner Devon , Wheeler Matthew T. , Bernstein Jonathan A. , Ruzhnikov Maura ,   Undiagnosed Diseases Network, Adams David R. , Hisama Fuki M. , Shashi Vandana 
Published: December 2024

ABSTRACTPatients with undiagnosed and/or rare disorders frequently manifest dysmorphic and neurological features. There is a lack of information on the effectiveness of telehealth in the evaluation of these disorders. We thus compared an unassisted virtual physical examination (PE) with an in‐person PE in undiagnosed individuals and also assessed participant telehealth satisfaction. Twenty‐six individuals enrolled in the Undiagnosed Diseases Network study underwent an in‐home synchronous virtual PE, and a subsequent in‐person PE, by the same clinician. The participants completed surveys on telehealth usability and provider empathy. On PE, general appearance and craniofacial features showed near perfect agreement (κ = 0.81–1.00) between the telehealth and in‐person evaluations. Specific components of the neurological examination demonstrated substantial agreement (speech, gait, coordination; κ > 0.61), whereas others had moderate agreement (muscle tone, strength; κ = 0.41–0.60), and a few had none to slight agreement (skin; κ < 0.20). Some systems could not be examined in the virtual PE. Importantly, features relevant to diagnosis or management were missed on the virtual PE in only 2/26 individuals. The participants were satisfied with the quality of the telehealth interaction, as well as empathy demonstrated by providers in the virtual interface. Telehealth is effective for PEs in undiagnosed diseases and is acceptable to affected individuals.
Bound States in the Continuum in Photonics and Metasurfaces: From Phenomena to Applications
Authors: Zhou Wenjie , Sun Guangcheng , Yuan Yueyi , Wang Yuxiang , Burokur Shah Nawaz , Wang Yue , Zhang Kuang 
Published: December 2024

AbstractBound states in the continuum (BICs) refer to nonradiative eigenmodes located within the radiation continuum, possessing infinitely high Q‐factor and enabling exceptionally strong light–matter interactions. BICs have found applications across various domains in photonics and metasurfaces, including nonlinear optical enhancement, vortex beam generation, sensor technology, microlasers, and other related areas. This work starts by classifying the phenomena of BICs and introducing the theoretical formation mechanisms and topological characteristics. Then, the current and advanced applications based on BIC‐devices are highlighted. Lastly, this work discusses the current challenges in studies related to BICs, such as structural precision, material selection, and measurement difficulties, and prospect the possible potentials in future developments. This review provides a theoretical background and application prospects of BIC‐engineered devices in optical and photonics fields, laying a solid foundation for future industrial applications.
A Molecular Engineering Approach to Conformationally Regulated Conductance Dualism in a Molecular Junction
Authors: Nau Moritz , Bro‐Jørgensen William , Linseis Michael , Bodensteiner Michael , Winter Rainer F. , Solomon Gemma C. 
Published: December 2024

AbstractOne key aspect for the development of functional molecular electronic devices is the ability to precisely tune and reversibly switch the conductance of individual molecules in electrode‐molecule‐electrode junctions in response to external stimuli. In this work, we present a new approach to access molecular switches by deliberately controlling the flexibility in the molecular backbone. We here describe two new conductance switches based on bis(triarylamines) that rely on the reversible toggling between two conformers, each associated with vastly different conductances. By molecular design, we were able to realize an on/off ratio Ghigh/Glow of ~103, which is one of the largest values reported to date. Flicker noise analysis and molecular transport calculations indicate that on/off switching relies on a change of the conduction pathway and vast differences in molecule‐electrode coupling. We thereby provide a new scaffold for further development of molecular conductance switches that are both efficient and easily refined.
A Conductive Cu‐Based Metal–Organic Framework Ribbon with High‐Density Redox‐Active Centers as Cathode for Stable High‐Capacity Lithium‐Ion Batteries
Authors: Yang Menghua , Wang Ying , Huang Yan‐Fang , Xiao Ji‐Miao , Zhu Guo‐Yu , Fang Ying , Zhou Xian‐Chao , Long Jian‐Hua , Xie Mo , Bin De‐Shan , Li Dan 
Published: December 2024

AbstractConductive Cu‐based metal–organic framework (Cu‐MOF) materials hold significant potential as cathodes for lithium‐ion batteries (LIBs) due to their flexible structural design, high electronic conductivity, and independence from costly resources. However, their practical application is often limited by their capacity and cyclability. In this study, we report a one‐dimensional Cu‐MOF (DDA−Cu, DDA=1, 5‐Diamino‐4, 8‐dihydroxy‐9, 10‐anthraceneedione) featuring extended π‐d conjugated coordination ribbon and high‐density redox‐active centers, making it a stable, high‐capacity cathode for LIBs. The π‐d conjugated Cu−O3N motifs embedded within the ribbon not only serve as redox‐active centers for enhanced lithium‐ion storage capacity but also contribute to structural robustness, enabling resistance against electrode solubility in organic electrolytes, thus ensuring superior cyclability. Furthermore, these π‐d conjugated Cu−O3N units promote efficient charge transfer, leading to high electronic conductivity at room temperature. These advantageous properties allow the Cu‐MOF cathode to deliver a remarkable capacity (353 mAh g−1 at 0.05 A g−1) and exceptional cyclability, achieving capacity retention of 78 % after 1000 cycles, surpassing state‐of‐the‐art MOF electrodes. Additionally, this DDA−Cu demonstrates considerable wettability with the electrolyte, achieving outstanding performance even when tested in a lean electrolyte environment (2 μL mg−1) with a high mass loading of the MOF (6.8 mg cm−2).
Industry‐Level Electrocatalytic CO2 to CO Enabled by 2D Mesoporous Ni Single Atom Catalysts
Authors: Ma Yao , Xiao Taishi , Zhu Kerun , Zhang Wei , Yin Ziqing , Dong Angang , Sun Zhengzong , Zhao Dongyuan , Li Wei 
Published: December 2024

AbstractElectrocatalytic CO2 reduction reaction (eCO2RR) has captivated widespread attentions, yet achieving the requisite efficiency, selectivity and stability for industrial applications poses a persistent challenge. Here, we report the synthesis of 2D mesoporous Ni single atom catalysts in N‐doped carbon framework via a bottom‐up interfacial assembly strategy. The 2D mesoporous Ni−N−C catalyst showcases an ultrathin thickness (~6.7 nm) with well‐distributed 5 to 40 nm‐width mesopores in plane and a high surface area. As a result, the Ni single atom sites with a high density (~6.0 wt %) are almost completely exposed and can be accessible, and the mass transfer can be greatly promoted even at high current densities. Thus, a high current density of 446 mA cm−2 with >95 % CO selectivity in a flow cell can be obtained. Concurrently, the catalyst demonstrates an impressive stability, maintaining a 50‐hours continuous electrolysis in the membrane electrode assembly test and achieving an energy efficiency of 42 %. Finite element analysis reveals that the 2D mesoporous design enhances CO2 diffusion, ensuring efficient adsorption and swift CO desorption at high current densities. Our study paves a way for the fabrication of 2D mesoporous single atom catalysts with nearly 100 % accessibility and expedited mass transport.
Metal–Organic Coordination Enhanced Metallopolymer Electrolytes for Wide‐Temperature Solid‐State Lithium Metal Batteries
Authors: Zhao Pei‐Chen , Wang Yaoda , Huang Qi‐Sheng , Jin Zhong , Li Cheng‐Hui 
Published: December 2024

AbstractThe practical application of polymer electrolytes is seriously hindered by the inferior Li+ ionic conductivity, low Li+ transference number (tLi+), and poor interfacial stability. Herein, a structurally novel metallopolymer is designed and synthesized by exploiting a molybdenum (Mo) paddle‐wheel complex as a tetratopic linker to bridge organic and inorganic moieties at molecular level. The prepared metallopolymer possesses combined merits of outstanding mechanical and thermal stability, as well as a low glass transition temperature (Tg <−50 °C). Based on this metallopolymer, an advanced metal–organic coordination enhanced metallopolymer electrolyte (MPE) is developed for constructing high‐performance solid‐state lithium metal batteries (LMBs). Due to the unsaturated coordination of Mo atoms, the uniformly distributed Mo‐polyoxometalates (Mo‐POMs) in metallopolymer skeleton can effectively immobilize anions (bis(fluorosulfonyl)imide anions, FSI−) and promote the dissociation of Li salts. Moreover, dynamic metal–organic coordination bonds endow the MPE with re‐processability and self‐healing, enabling it to accommodate electrode volume changes and maintain good interfacial contact. Consequently, the MPE achieves a competitive ionic conductivity of 0.712 mS cm−1 (25 °C), a high tLi+ (0.625), and a wide electrochemical stability window (>5.0 V). This study presents a unique MPE design based on metal–organic coordination enhanced strategy, providing a promising solution for developing wide‐temperature solid‐state LMBs.