bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERBANDINGAN KINERJA PEMERINTAH DAERAH DI INDONESIA
Authors: Nurhayati Netty , Rizani Fahmi , - Kadir 
Published: July 2019

<p><em>This study aims to compare the performance of district / city governments in Indonesia that obtain WTP and Non-WTP opinion from BPK RI for 2014-2016 period. The financial performance variables are measured by financial ratios (decentralization degree ratio, independence ratio, effectiveness ratio , growth ratio) and performance of local government administration are measured by performance evaluation score of local government administration (EKPPD score). Sampling method using purposive sampling with judgment sampling technique. The sample in this study 216 districts / cities, consisting of 108 districts / cities that obtain WTP opinion and 108 districts / cities that obtain Non-WTP opinion. Hypothesis testing using nonparametric test ‘Mann-Whitney U Test’. The results of this study, state that the financial performance of local government and performance of local government administration on district / city governments in Indonesia that obtain WTP opinion is significantly different and better than district / city governments in Indonesia that obtained Non-WTP opinion</em>. <em>This difference shows that district / city government that obtain WTP opinion has proven to be better in terms of financial management and local government administration compared to those who obtain Non WTP opinions.</em><em></em></p>
An Integrated Approach To Optimize Bottomhole-Pressure-Drawdown Management for a Hydraulically Fractured Well Using a Transient Inflow Performance Relationship
Authors: Wang Junlei , Luo Wanjing , Chen Zhiming 
Published: July 2019

SummaryThe purpose of this paper is to determine the optimal strategy of bottomhole-pressure (BHP) drawdown management in a hydraulically fractured well with pressure-sensitive conductivity to remain conductive while maintaining a high enough drawdown to maximize the estimated ultimate recovery (EUR). In this work, a novel permeability-decay coefficient accounting for dynamic conductivity effect (DCE) is proposed to represent the pressure sensitivity in a fracture on the basis of experimental results. Using an existing method, the constant/variable BHP conditions and the hydraulic fractures with DCE are considered in the model. Model verification is performed by comparing with the solutions from the numerical method. Then, the mechanism of fracture closure and its effect on production performance are investigated using the semianalytical solution, and the interplay between pressure drawdown and productivity loss is captured by generating a set of type curves for the transient inflow performance relationship (TIPR).Next, an easy-to-use approach is developed to find the optimal path of BHP decline vs. time, and the practical optimal drawdown is calibrated by capturing the time-lapse behavior, with consideration of the effect of production history on TIPR. It is found that if the relation of decay coefficient and pressure is a linear function, there will be a reversal behavior on TIPR as BHP drawdown increases. That is to say, an operating point exists on the TIPR curves, beyond which the production rate decreases; otherwise, the production rate increases. The operating point is defined as the optimal BHP drawdown at a given time, and the optimal profile of BHP drawdown is achieved by integrating operating points on TIPR curves corresponding to different times. Subsequently, a synthetic case generated by a coupled-geomechanical/reservoir simulator is defined to demonstrate that an optimal BHP-drawdown schedule developed by the semianalytical approach has the ability to enhance ultimate recovery by reducing the effective stress on the stress-sensitive fracture while maintaining the well productivity.
Determinants of Birth Asphyxia among Newborns in Amhara National Regional State Referral Hospitals, Ethiopia
Authors: Meshesha Alemwork Desta , Azage Muluken , Worku Endalkachew , Bogale Getahun Gebre 
Published: July 2019

Abstract
Background

Globally, every year, 2.5 million infants die within their first month of life. Neonatal asphyxia is the leading specific cause of neonatal mortality in low- and middle-income countries, including Ethiopia. Therefore, the aim of this study was to identify the determinants of birth asphyxia among newborns admitted in Amhara region referral hospitals, Ethiopia.

Methods

Facility-based unmatched case-control study was employed among 193 cases and 193 controls of newborns. Newborns admitted to neonatal intensive care units with admission criteria of birth asphyxia and without birth asphyxia were considered as cases (Apgar score<7) and controls (Apgar score>=7) respectively. Data were collected using a structured questionnaire by systematic random sampling technique with proportional allocation, and entered in to Epi-Info version 7 and exported to SPSS version 20 for statistical analysis. Bivariate and multivariable logistic regression models were fitted to identify determinants of birth asphyxia.

Results

Newborns with low birth weight (<2.5kg) had 8.94 higher odds of birth asphyxia than those whose weight at birth was >=2.5kg at birth (AOR: 8.94, 95% CI: 4.08, 19.56). Newborns born at health centers were 7.36 times more likely to develop birth asphyxia than those born at hospitals (AOR: 7.36, 95% CI: 2.44, 22.13). Newborns born using instrumental delivery were 3.03 times more likely to develop birth asphyxia than those delivered by vaginally (AOR: 3.03, 95% CI: 1.41, 6.49). Newborns from mothers with prolonged labor were 2 times more likely to suffer from birth asphyxia as compared to their counterparts (AOR: 2.00, 95% CI: 1.20, 3.36).

Conclusion

This study identified prolonged labor, instrumental delivery, delivered at health centers, and low birth weight were identified as determinants of birth asphyxia. Thus, intervention planning towards the identified determinants may be needed to reduce neonatal birth asphyxia.
Isolation and Identification of Streptococcus suis from sick pigs in Bali, Indonesia
Authors: Besung Nengah I. K. , Suarjana Gusti Ketut , Agustina Karang Kadek , Winaya Oka Ida Bagus , Soeharsono Hamong , Suwiti Ketut Ni , Mahardika Gusti Ngurah 
Published: July 2019

Abstract
Background
Streptococcus suis (S. suis) is a causative agent for various syndromes in pigs. It can be transmitted to humans with typical symptoms of meningitis and death. Data in Bali Referral Hospital showed more than 40 confirmed human cases of S. suis meningitis in 2014. Cases of S. suis infection in pigs have never been confirmed in the province. Here we provide evidence of the bacteria in sick pigs in that world tourist destination province.
Results
The S. suis was confirmed in eight out of 30 cases. Prominent histopathological lesions of confirmed cases were meningitis, endocarditis, pericarditis, bronchopneumonia, enteritis, and glomerulonephritis. The dominant inflammatory cells were neutrophils and macrophages.
Conclusions
Streptococcus suis has been confirmed in sick pig in Bali, Indonesia. Further research is needed to understand the risk factor of human infection. Awareness of the community on the risk of contracting S. suis is needed to prevent human infections.
Does the shoe really fit? Characterising ill-fitting footwear among community dwelling older adults: an observational cross-sectional study
Authors: O'Rourke Brian , Walsh Mary E , Brophy Rachael , Vallely Shanice , Murphy Niamh , Conroy Bronagh , Cunningham Conal , Horgan Frances 
Published: July 2019

Abstract
Background

Falls in older people are common and can result in loss of confidence, fear of falling, restriction in activity and loss of independence. Causes of falls are multi-factorial and include extrinsic factors such as unsafe footwear. Inappropriate footwear may increase the risk of falls. There is a paucity of research assessing the footwear characteristics among older people who are at high risk of falls, internationally and in the Irish setting. The aim of this study was to examine the proportion of older adults attending a geriatric day hospital in Ireland who were wearing incorrectly sized shoes.

Methods

A consecutive sample of 111 older adults aged 60 years and over attending a geriatric day hospital in a large Irish teaching hospital was recruited. Demographic data including age, mobility, medications, use of glasses, social support, footwear worn at home and falls history were recorded. Shoe size and foot length were measured in millimetres using an internal shoe gauge and SATRA shoe size stick, respectively. Subjects’ self-reported shoe size was recorded. Footwear was assessed using the Footwear Assessment Form (FAF). A Timed Up and Go (TUG) score was recorded. Participation was assessed using the Nottingham Extended Activities of Daily Living (NEADL) Scale. Those with shoes fitting on at least one foot were compared to those with ill-fitting footwear on both feet using Chi-square tests, T-tests or Mann–Whitney U tests.

Results

72% of participants were wearing footwear that did not fit correctly on both feet according to our definition based on previous literature. Only 6% were wearing footwear that fitted correctly on both feet. 67% wore slippers at home. 90% had shoes with smooth, partly worn or fully worn sole treading. Participant age, TUG score and NEADL score were not associated with ill-fitting footwear.

Conclusions

Wearing incorrectly fitting shoes and shoes with unsafe features is common among older adults attending geriatric day services. The large number of participants who reported wearing slippers at home is also an important finding. Ill-fitting footwear and slippers are risk factors for falls thus warranting further investigation to help guide future falls prevention services at day hospitals.
Does GRASP affect DCE-MRI for assessing response to neoadjuvant chemotherapy in patients with esophageal cancer?
Authors: Lu Yanan , Ma Ling , QIN Jianjun , Wang Zhaoqi , Guo Jia , Zhao Yan , Zhang Hongkai , Yan Xu , Liu Hui , Li Hailiang , Qu Jinrong 
Published: July 2019

Abstract
Purpose
To compare the value of two dynamic contrast-enhanced Magnetic Resonance Images (DCE-MRI) reconstruction approaches, namely golden-angle radial sparse parallel (GRASP) and view-sharing with golden-angle radial profile (VS-GR) reconstruction, and explore their values in assessing response to neoadjuvant chemotherapy (nCT) in esophageal cancer (EC).
Methods
The study prospectively enrolled EC patients receiving nCT before surgery. DCE-MRI scanning was performed after nCT and within 1 week before surgery. Chemotherapy response was assessed according to Tumor Regression Grade (TRG), and patients were stratified into a responsive group (TRG1+2) and a non-responsive group (TRG3+4+5). Wilcoxon test was utilized for comparing GRASP and VS-GR reconstruction, and Kruskal-Wallis and Mann-Whitney test was performed for each parameter to assess response, and Spearman test was performed for analyzing correlation between parameters and TRGs, as well as responder and non-responder.
Results
Among the 64 patients included in this cohort (52 male, 12 female; average age of 59.1±7.9 years), 4 patients showed TRG1, 4 patients were TRG2, 7 patients were TRG3, 11 patients were TRG4, and 38 patients were TRG5. They were stratified into 8 responders and 56 non-responders.
A total of 15 parameters were calculated from each tumor. With VSGR, 10/15 parameters significantly correlated with TRG and response groups. Of these, only AUCmax showed moderate correlation with TRG, 7 showed low correlation and 2 showed negligible correlation with TRG. 8 showed low correlation and 2 showed negligible correlation with response groups. With GRASP, 13/15 parameters significantly correlated with TRG and response groups. Of these, 10 showed low correlation and 3 showed negligible correlation with TRG. 11 showed low correlation and 2 showed negligible correlation with TRG.

Conclusion
In patients with esophageal cancer on neoadjuvant chemotherapy, several parameters can differentiate responders from non-responders, using both GRASP and VS-GR techniques. GRASP may be able to better differentiate these two groups compared to VS-GR.
Factors affecting weight and body composition in childhood cancer survivors – cross sectional study
Authors: Sawicka-Zukowska Malgorzata , Łuczyński Włodzimierz , Dobroch Jakub , Krawczuk-Rybak Maryna 
Published: July 2019

Abstract
Background

Due to improved efficacy of antitumour treatment in the general population, there are increasingly more childhood cancer survivors. However, some of these survivors are at risk of distant complications including cardiovascular disease. We aimed to examine the risk of overweight/obesity and abnormal body composition in a large group of patients from our paediatric oncology centre.

Method

We used anthropometric methods and electrical bioimpedance to assess these features, and then determined their association with disease and treatment.

Results

We found patients treated for leukaemia/lymphoma (especially boys) had significantly higher rates of overweight/obesity compared to the other patient groups. In contrast, overweight/obesity was more common in girls among patients treated for solid tumours. Patients treated for leukaemia/lymphoma were characterized by a higher body fat content compared to those treated for solid tumours and controls. During treatment for cancer patients had a higher percentage of muscle mass deficiency compared to those in the control group. Our regression analysis showed time from completion of treatment, gender, and type of therapy (radiotherapy, megachemotherapy) were associated with body weight and body composition including fat and muscle content.

Conclusions

We recommend pediatricians and general practitioners should actively try to detect and prevent cardiovascular disease among childhood cancer survivors.
VOPP1 promotes hepatocellular carcinoma proliferation through MAPK14 and RPS6KB1
Authors: Dai Haojiang , Hu Peng , Wang Binfeng , Han Qiuyue , Xu Yongfu , Lv Shangdong , Zhu Yu , Gan Meifu , Zhou Weijie , Fang Zheping , Zhang Wenlong 
Published: July 2019

Abstract
Background: The present study aimed to investigate the role of VOPP1 in hepatocellular carcinoma (HCC).
Methods: Immunohistochemistry(IHC), Western blot and Reverse-transcription polymerase chain reaction (RT-PCR) were used to analyze the expression of VOPP1 protein, the expression of VOPP1, MAPK14, RPS6KB1, CYLD and TWIST1 and the mRNA expression of VOPP1, MAPK14, RPS6KB1, CYLD and TWIST1. The cell proliferation and apoptosis were tested using Celigo cell imaging analyzer and annexin V-APC apoptosis detection kit respectively. Colony formation and tumor xenograft assays was performed to understand their roles in tumorigenicity.
Results: The expression of VOPP1 in HCC samples was higher than that in adjacent noncancerous tissues by immunohistochemistry. In addition, the deletion of VOPP1 using shRNA inhibited cell proliferation and tumour growth, and induced cell apoptosis in vitro and in vivo. Furthermore, VOPP1 silencing decreased the expression of MAPK14 and RPS6KB1, indicating that the MAPK and mTOR signalling pathways might be involved in VOPP1-mediated cancer cell proliferation.
Conclusion: The present data indicates that VOPP1 may play an important role in the progression of HCC by targeting the MAPK and mTOR signalling pathways, and that VOPP1 may potentially be a candidate as a novel molecular target for HCC therapy.
PREST: Pain REduction with bone metastases STereotactic radiotherapy: A phase III randomized multicentric trial
Authors: Cellini Francesco , Manfrida Stefania , Deodato Francesco , Cilla Savino , Maranzano Ernesto , Pergolizzi Stefano , Arcidiacono Fabio , Franco Rossella Di , Pastore Francesco , Muto Matteo , Borzillo Valentina , Donati Costanza , Siepe Giambattista , Parisi Salvatore , Salatino Antonia , D'Agostino Antonino , Montesi Giampaolo , Santacaterina Anna , Fusco Vincenzo , Santarelli Mario , Gambacorta Maria Antonietta , Corvò Renzo , Morganti Alessio Giuseppe , Masiello Valeria , Muto Paolo , Valentini Vincenzo 
Published: July 2019

Abstract
Background

Palliative antalgic treatments represent an issue for clinical management and a challenge for scientific research. Radiotherapy (RT) plays a central role. Techniques such as stereotactic body radiotherapy (SBRT) were largely investigated in several phase 2 studies with good symptom response, becoming widely adopted. Still is lacking evidence from randomized, direct comparison of RT and SBRT.

Methods/Design

The PREST trial was designed as an interventional study without medicinal, randomized 1:1, open-label, multicentric, phase 3. Inclusion criteria: painful spinal bone metastases presenting pain level >4 (or >1 if assuming analgesic) at numeric rating scale (NRS); expected intermediate/high prognosis (superior to 6 months) according to the Mizumoto prognostic score; low spine instability neoplastic score (SINS) sores (<7); magnetic resonance imaging (MRI) assessment of the bulky lesion. Patients will be assigned to either standard conventional radiotherapy administering 4 Gy x5 fractions (fx) to whole involved vertebra or SBRT by intensity modulated radiotherapy with simultaneous integrated boost (IMRT-SIB) administering 7 Gy x3 fx (to the whole involved vertebra) + 10 Gy x3 fx on the macroscopic disease (Gross Tumor Volume -GTV). In the experimental arm, the GTV will be contoured by registration with baseline MRI.

Discussion

Primary endpoint is overall pain reduction, defined in term of variation between baseline and 3-month evaluation; pain will be measured by Numeric Rating Scale (NRS) score. Secondary endpoints include: pain control duration; retreatment rates (after a minimum interval of 1 month); local control assessed with RECIST Criteria; symptom progression free survival; progression free survival; overall survival and quality of life (at 0, 30 and 90 days). Accrual of 330 lesions is planned. Experimental arm is expected to improve overall pain response rates of 15% respect to standard arm (60% according to Chow et al 2012).
Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography
Authors: Peng Jingyi , Zhong Liuxueying , Ma Li , Jin Jiayi , Zheng Yongxin , Jin Chenjin 
Published: July 2019

Abstract
Background: The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods: 12 normal adult cynomolgus macaques with a mean age of 4.91±0.43 years were studied for data collection. The macula of 28 adult healthy humans (14 males and 14 females), with a mean age of 25.11±6.21 years and the optic discs of 9 adult healthy humans (4 males and 5 females) with a mean age of 28.56±6.78 years were measured. The vessel density (VD) was measured using an RTVue XR with AngioVue. The scan sizes of the macular and optic discs were 3×3 mm and 4.5×4.5 mm, respectively. Results: OCT-A can image the superficial and deep capillary plexuses and radial peripapillary capillary network. In RPC layer of the optic disc, the VD in the nasal quadrant was lower than the VD in the inferior temporal quadrant. Similarities and significant differences in VD between healthy humans and cynomolgus macaques were obtained using OCT-A. Conclusions: This study provides normal vascular parameters for adult cynomolgus macaques using OCT-A to help establish an optical parameter database for cynomolgus macaques and compare VD between healthy humans and cynomolgus macaques to promote choroid-retinopathy research. Trial registration: Current Controlled Trials NCT03692169
Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression
Authors: Reimer Michael J , Pulakanti Kirthi , Shi Linzheng , Abel Alex , Liang Mingyu , Malarkannan Subramaniam , Rao Sridhar 
Published: July 2019

Abstract
Background: The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical role during early mammalian development and pluripotency¬. While multiple groups have generated knockouts combining loss of different Tet proteins in murine embryonic stem cells (ESCs), differences in genetic background and approaches has made it difficult to directly compare results and discern the direct mechanism by which Tet proteins regulate the transcriptome. To address this concern, we utilized genomic editing in an isogenic pluripotent background which permitted a quantitative, flow-cytometry based measurement of pluripotency in combination with genome-wide assessment of gene expression and DNA methylation changes. Our ultimate goal was to generate a resource of large-scale datasets to permit hypothesis-generating experiments.
Results: We demonstrate a quantitative disparity in the differentiation ability among Tet protein deletions, with Tet2 single knockout exhibiting the most severe defect, while loss of Tet1 ¬alone or combinations of Tet genes showed a quantitatively intermediate phenotype. Using a combination of transcriptomic and epigenomic approaches we demonstrate an increase in DNA hypermethylation and a divergence of transcriptional profiles in pluripotency among Tet deletions, with loss of Tet2 having the most profound effect in undifferentiated ESCs.
Conclusions: We conclude that loss of Tet2 has the most dramatic effect both on the phenotype of ESCs and the transcriptome compared to other genotypes. While loss of Tet proteins increased DNA hypermethylation, especially in gene promoters, these changes in DNA methylation did not correlate with gene expression changes. Thus, while loss of different Tet proteins alters DNA methylation, this change does not appear to be directly responsible for transcriptome changes. Thus, loss of Tet proteins likely regulates the transcriptome epigenetically both through altering 5mC but also through additional mechanisms. Nonetheless, the transcriptome changes in pluripotent Tet2-/- ESCs compared to wild-type implies that the disparities in differentiation can be partially attributed to baseline alterations in gene expression.