bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic, Transcriptomic, Epigenetic, and Immune Profiling of Mucinous Breast Cancer
Authors: Nguyen Bastien , Veys Isabelle , Leduc Sophia , Bareche Yacine , Majjaj Samira , Brown David N , Boeckx Bram , Lambrechts Diether , Sotiriou Christos , Larsimont Denis , Desmedt Christine 
Published: February 2019

Abstract
Although invasive ductal breast cancer (IDC) represents the most common histological type of breast cancer, minor subtypes exist such as mucinous breast cancer (MuBC). MuBC are distinguished by tumor cells floating in extracellular mucin. MuBC patients are generally older and associated with a favorable prognosis. To unravel the molecular architecture of MuBC, we applied low-pass whole-genome sequencing and microscopic evaluation of stromal tumor infiltrating lymphocytes to 30 MuBC from a retrospective institutional cohort. We further analyzed two independent datasets from the International Cancer Genomics Consortium and The Cancer Genome Atlas. Genomic data (n = 26 MuBC, n = 535 estrogen receptor [ER] positive/HER2-negative IDC), methylation data (n = 28 MuBC, n = 529 ER-positive/HER2-negative IDC), and transcriptomic data (n = 27 MuBC, n = 467 ER-positive/HER2-negative IDC) were analyzed. MuBC was characterized by low tumor infiltrating lymphocyte levels (median = 0.0%, average = 3.4%, 95% confidence interval = 1.9% to 4.9%). Compared with IDC, MuBC had a lower genomic instability (P = .01, two-sided Mann-Whitney U test) and a decreased prevalence of PIK3CA mutations (39.7% in IDC vs 6.7% in MuBC, P = .01 in the International Cancer Genomics Consortium; and 34.8% vs 0.0%, P = .02 in The Cancer Genome Atlas, two-sided Fisher’s exact test). Finally, our report identifies aberrant DNA methylation of MUC2 as a possible cause of extracellular production of mucin in MuBC.
Modular Survey Design: Experimental Manipulation of Survey Length and Monetary Incentive Structure
Authors: Peytchev Andy , Peytcheva Emilia , Conzelmann Johnathan G , Wilson Ashley , Wine Jennifer 
Published: February 2019

Abstract
Survey length and monetary incentives are design features that have been found to affect survey participation in opposing ways. Declining response rates make these key design features even more important. However, survey length has received surprisingly little attention, possibly being viewed as a static survey attribute rather than an alterable design feature. In addition, experimental tests of the interaction between survey length and monetary incentives could not be found, despite calls for the need for such research and theories that support such an interaction.
Leverage-salience theory leads to opposing expectations, depending on the relative importance people give to different factors affecting survey participation. Making the survey request in parts, to reduce burden, may increase participation. Yet, it may instead decrease participation relative to the status quo of offering the full incentive for the entire survey if incentives play a larger role than survey length. When factoring both burden and motivation, the results for survey length could likely depend on the structure of monetary incentives. We designed an experiment to test a modularized survey, ending one part of the survey with a request to complete another part. Respondents in the modular survey design were also assigned to proportionate or disproportionate incentives—offering a larger proportion of the incentive for the initial survey request. Surprisingly, the two-part survey request led to not lower but greater nonresponse. There was increased potential for nonresponse bias attributable to nonresponse to the second request, without reduction in item nonresponse and measurement error. Disproportionate allocation of incentives across modules seemed to increase overall participation compared with proportionate allocation. The lack of a beneficial effect of a request for a shorter survey and the results on incentive allocation have important implications for survey practitioners. Furthermore, the inconsistency in findings on survey length requires further research to identify mediating factors.
A Profile of Point of Care Coordinators: Roles, Responsibilities and Attitudes
Authors: Gledhill Tyler R , White Sandra K , Lewis Jamie E , Schmidt Robert L 
Published: February 2019

Abstract

Background
Point of care (POC) testing is rapidly evolving. POC testing is often managed by POC coordinators (POCC), but this role is relatively new and has not been characterized.

Objectives
To characterize the background, responsibilities, and job satisfaction of POCCs.

Methods
Structured interviews were conducted with 15 POCCs. On the basis of these interviews, a 38-item questionnaire was developed and administered as a web-based survey.

Results
The respondents (N = 98) were mostly female (87%) and had a bachelor’s degree (79%). About half the respondents were older than 55 years and were in supervisory positions. Overall, respondents indicated high job satisfaction, but women were significantly less satisfied than men. POCCs were infrequently involved in decisions regarding the implementation of new tests. The number of tests managed by each POCC varied widely (median, 6.0; range, 1–30).

Conclusions
The POCC role is in flux. There is consensus regarding some aspects of the job, but there are significant differences in the way that hospitals organize the POCC function.
Urgent Delivery - Validation and Operational Implementation of Urgent Blood Delivery by Modern High Speed Hospital Pneumatic Tube System to Support Bleeding Emergencies Within a Hospital Massive Transfusion Protocol
Authors: Chay Jason Wai Mun , Kim Ji Hyun , B M Taha Nur Shahirah , Chiew Siew Hong , Chin Kwong Weng , Lim Shu Hong , Ho Liam Pock 
Published: February 2019

Abstract

Background
Timely blood delivery to patients with critical bleeding poses logistic challenges. A modern, high speed hospital pneumatic tube system (PTS) is one solution, but blood units may be subjected to high-speed torque and acceleration/deceleration forces.

Objective
To validate a new PTS system for potential use at our 1,400-bed hospital in Singapore.

Method
Our validation included red blood cells, platelets, thawed plasma, and cryoprecipitate units transported from the blood bank for a distance of 820 meters (PTS track), at a velocity of 3–6 meters per second. Transit time, temperature, bag integrity, and blood quality were assessed visually and through analytical testing on pre- and post-PTS specimens.

Results
Blood units arrived physically intact in less than 8 minutes. The temperature for each was within the acceptable range. Comparative testing of pre-PTS and post-PTS specimens showed no significant difference in physical quality and analyzed parameters (P> .05).

Conclusions
High speed PTS transportation of blood components has satisfactory fidelity and speed, without significant impact on quality. As a result, we incorporated PTS blood delivery into the hospital massive-transfusion protocol and successfully operationalized that new system.
Analysis of mystical concepts in Khaghani’s Divan
Authors: Yin Ming-Ming , Mahmoudi Mohammad Reza , Abbasalizadeh Ali 
Published: February 2019

Abstract
Text analysis provides an exciting approach for extracting knowledge from text data. Recently, text analysis has been applied in many research fields. In this study, it was demonstrated that how text analysis can be applied to literary researches. All the lines of Khaghani’s Divan have been considered using different text analysis methods. Then the accuracy of the applied methods is compared.
Comparing immunochromatography with latex antigen agglutination testing for the diagnosis of cryptococcosis in cats, dogs and koalas
Authors: Krockenberger Mark B , Marschner Caroline , Martin Patricia , Reppas George , Halliday Catriona , Schmertmann Laura J , Harvey Andrea M , Malik Richard 
Published: February 2019

AbstractAlthough the point-of-care cryptococcal antigen lateral flow assay (LFA) has revolutionized the diagnosis of cryptococcosis in human patients, to date there has been no large-scale examination of this test in animals. We therefore assessed the LFA in cats, dogs and koalas suspected of having cryptococcosis. In sum, 528 serum specimens (129 from cats, 108 from dogs, 291 from koalas) were tested using the LFA and one of two commercially available latex cryptococcal antigen agglutination test (LCAT) kits. The LCAT is a proven and well-accepted method in veterinary patients and therefore taken as the “gold standard” against which the LFA was compared. The LFA achieved a sensitivity of 92%, 100%, and 98% in cats, dogs, and koalas, respectively, with corresponding negative predictive values of 94%, 100%, and 98%. The specificity of the LFA was 81%, 84%, and 62% for cats, dogs, and koalas, respectively, with corresponding positive predictive values of 76%, 48%, and 69%. These findings suggest the most appropriate role for the LFA is as a screening test to rule out a diagnosis of cryptococcosis in cats, dogs, and koalas. Point-of-care accessibility makes it equally suited for use in the field and as a cage-side test in veterinary hospitals. The suboptimal specificity of the LFA makes it less suited to definitive confirmation of cryptococcosis in animals; therefore, all LFA-positive test results should be confirmed by LCAT testing. The discrepancy between these observations and the high specificity of the LFA in humans may reflect differences in the host-pathogen interactions amongst the species.
Clinical and microbiological characteristics of paracoccidioidomycosis in patients with AIDS in Buenos Aires, Argentina
Authors: Messina F , Romero M , Benchetrit A , Marin E , Arechavala A , Depardo R , Negroni R , Santiso G 
Published: February 2019

Abstract
Paracoccidioidomycosis (Pm) is a systemic disease, endemic in the American continent. There are two different clinical forms, the infant-juvenile or subacute form (PmS) and the chronic adult form (PmC). The human immunodeficiency virus (HIV) associated paracoccidioidomycosis (PmHIV) shares characteristics with both of the previously mentioned forms. The objective of this work was to describe the epidemiological, clinical and laboratory features of the PmHIV and to compare them with the ones of PmS and the PmC. A retrospective analysis of 119 patients with paracoccidioidomycosis was performed. Ninety four suffered the chronic form, 11 the subacute one and 14 were coinfected with HIV. Patients with PmHIV presented a CD4+ T lymphocytes median of 70.5 cells/μl, 71.4% had fever, 64.3% had a miliary pattern on the chest radiography, 64.3% had hepatosplenomegaly, 64.3% had mucosal lesions and 50% had skin lesions. One patient died during his hospitalization. The clinical presentation of Pm in patients with HIV resembled the subacute form with fever, hepatomegaly and skin lesions. However, they also tended to present mucosal lesions, positive serology for Pm and pulmonary parenchyma lesions as usually seen in PmC (9/14 PmHIV patients had overlapping features, while 4/14 PmHIV patients clinically resembled PmS and 1/14 PmC). The incidence of Pm has not changed with the burden of AIDS as it has happened with other fungal infections but it appears clinically different from the classic clinical forms of the disease.
Serendipitous discoveries of kilonovae in the LSST main survey: maximizing detections of sub-threshold gravitational wave events
Authors: Setzer Christian N , Biswas Rahul , Peiris Hiranya V , Rosswog Stephan , Korobkin Oleg , Wollaeger Ryan T ,   (The LSST Dark Energy Science Collaboration)
Published: February 2019

AbstractWe investigate the ability of the Large Synoptic Survey Telescope (LSST) to discover kilonovae (kNe) from binary neutron star (BNS) and neutron star–black hole (NSBH) mergers, focusing on serendipitous detections in the Wide-Fast-Deep (WFD) survey. We simulate observations of kNe with proposed LSST survey strategies, focusing on cadence choices that are compatible with the broader LSST cosmology programme. If all kNe are identical to GW170817, we find the baseline survey strategy will yield 58 kNe over the survey lifetime. If we instead assume a representative population model of BNS kNe, we expect to detect only 27 kNe. However, we find the choice of survey strategy significantly impacts these numbers and can increase them to 254 and 82 kNe over the survey lifetime, respectively. This improvement arises from an increased cadence of observations between different filters with respect to the baseline. We then consider the detectability of these BNS mergers by the Advanced LIGO/Virgo (ALV) detector network. If the optimal survey strategy is adopted, 202 of the GW170817-like kNe and 56 of the BNS population model kNe are detected with LSST but are below the threshold for detection by the ALV network. This represents, for both models, an increase by a factor greater than 4.5 in the number of detected sub-threshold events over the baseline strategy. These sub-threshold events would provide an opportunity to conduct electromagnetic-triggered searches for signals in gravitational-wave data and assess selection effects in measurements of the Hubble constant from standard sirens, e.g. viewing angle effects.
Initial Emergency Room Triage of Acute Ischemic Stroke
Authors: Waqas Muhammad , Vakharia Kunal , Munich Stephan A , Morrison John F , Mokin Maxim , Levy Elad I , Siddiqui Adnan H 
Published: February 2019

Abstract
Early recognition and differentiation of acute ischemic stroke from intracranial hemorrhage and stroke mimics and the identification of large vessel occlusion (LVO) are critical to the appropriate management of stroke patients. In this review, we discuss the current evidence and practices surrounding safe and efficient triage in the emergency room. As the indications of stroke intervention are evolving to further improve stroke care, focus has begun to revolve around recognition of LVO and provision of endovascular thrombectomy with or without the administration of tissue plasminogen activator. Systems of stroke care are being organized to achieve this goal without delay. Clinical history is important in determining time of onset or last known well time, but, alone or along with an examination, it cannot reliably predict an LVO or exclude intracranial hemorrhage and stroke mimics. The choice of imaging is influenced mainly by the duration of symptoms. On the basis of recent trials, patients presenting after the 6-h therapeutic window can be considered for endovascular thrombectomy if the computed tomographic or magnetic resonance perfusion imaging shows favorable findings. The Society of NeuroInterventional Surgery has established time metrics for each step of triage and initial management. Hospitals are required to develop multidisciplinary stroke teams and emergency protocols to meet these goals. There also needs to be coordination of the emergency medical services with the emergency facility of an appropriate stroke center (a primary stroke center, comprehensive stroke care center, or a thrombectomy-capable stroke center).
Functional Outcomes After Revascularization Procedures in Patients With Hemorrhagic Moyamoya Disease
Authors: Abhinav Kumar , Furtado Sunil V , Nielsen Troels H , Iyer Aditya , Gooderham Peter A , Teo Mario , Lee Justin , Han Summer S , Steinberg Gary K 
Published: February 2019

Abstract

BACKGROUND
Poor natural history of hemorrhagic Moyamoya disease (MMD) is related to high rehemorrhage rates between 32% and 61%. Postrevascularization, rehemorrhage rates reportedly decrease to 12% to 17%.

OBJECTIVE
To evaluate long-term functional outcomes and rehemorrhage rates of hemorrhagic MMD patients treated with surgical revascularization and examine these in relation to clinical and radiological factors.

METHODS
Patients treated surgically for hemorrhagic MMD over a 26-yr period were identified. Modified Rankin scale (mRS) was used to assess clinical status at presentation and functional outcomes. Multivariable regression analyses were performed to evaluate the risk factors associated with rehemorrhage rates and functional outcomes.

RESULTS
A total of 104 patients (mean age: 38.04 yr) were identified. The mean mRS score at baseline was 1.3. Of 172 revascularized hemispheres, 157 (91.3%) were direct superficial temporal artery (STA)-middle cerebral artery (MCA) bypasses and the rest indirect. Over the mean follow-up of 61.4 mo, 8 of 104 patients (7.7%) experienced rehemorrhage with rehemorrhage rate per person-years of 1.9%. A total of 4 patients died with 1 related to rehemorrhage. At the last follow-up, mean mRS score improved to 1.1. No significant risk factors were identified in relation to the rehemorrhage rates (P < .05). The patients’ initial mRS score was positively associated with mRS scores at the final follow-up (P < .001). STA-MCA direct bypass was associated with better performance status (P = .033).

CONCLUSION
Rehemorrhage rate following surgical revascularization of the hemorrhagic MMD patients at 7.7% is lower compared with much higher natural history rates. Surgical revascularization improved patients' performance status. These outcomes support performing revascularization procedure with a preference for direct STA-MCA bypasses.
Management of Subdural Hematohygromas in Abusive Head Trauma
Authors: Nguyen Vincent N , Wallace David , Ajmera Sonia , Akinduro Oluwatomi , Smith Lydia J , Giles Kim , Vaughn Brandy , Klimo Paul 
Published: February 2019

Abstract

BACKGROUND
The optimal management of nonacute subdural fluid collections in infantile abusive head trauma (AHT) remains controversial.

OBJECTIVE
To review the outcomes and costs of the various treatments for symptomatic subdural fluid collections in children with AHT at a single center.

METHODS
Our AHT database was queried to identify children requiring any intervention for hematohygromas. Demographic, hospital course, radiologic, cost, readmission, and follow-up information were collected.

RESULTS
From January 2009 to March 2018, the authors identified 318 children with AHT, of whom 210 (66%) had a subdural collection of any type (blood or cerebrospinal fluid). A total of 50 required some form of intervention specifically for chronic hematohygromas. The initial management consisted of transfontanelle percutaneous aspiration (n = 31), burr holes with (n = 12) or without (n = 3) external subdural drainage, and mini-craniotomy (n = 4). Of those who were initially managed with 1 or more needle aspiration, 23 (74%) required further intervention—12 subduroperitoneal shunts and 11 nonshunt procedures. No patient who underwent burr holes/external drainage required further intervention (n = 16). Overall, the average number of interventions needed in these 50 children for definitive treatment was 1.8 (range, 1-4). A total of 15 children ultimately required a subduroperitoneal shunt. Complications (infectious, hemorrhagic, and thrombotic) were significant and occurred in all treatment groups except burr holes without drainage (n = 3). The average hospital charge for the entire cohort was $166 300.25 (range, $19 126-$739 248).

CONCLUSION
Based on our experience to date, burr hole with controlled external subdural drainage is an effective and preferred treatment for traumatic hematohygromas; complications and need for additional intervention is low.
Prevalence and severity of sleep difficulty in patients with a CNS cancer receiving palliative care in Australia
Authors: Jeon Megan S , Dhillon Haryana M , Descallar Joseph , Lam Lawrence , Allingham Samuel , Koh Eng-Siew , Currow David C , Agar Meera R 
Published: February 2019

Abstract

Background
The literature describing the incidence of sleep difficulty in CNS cancers is very limited, with exploration of a sleep difficulty symptom trajectory particularly sparse in people with advanced disease. We aimed to establish the prevalence and longitudinal trajectory of sleep difficulty in populations with CNS cancers receiving palliative care nationally, and to identify clinically modifiable predictors of sleep difficulty.

Methods
A consecutive cohort of 2406 patients with CNS cancers receiving palliative care from sites participating in the Australian national Palliative Care Outcomes Collaboration were evaluated longitudinally on patient-reported sleep difficulty from point-of-care data collection, comorbid symptoms, and clinician-rated problems. Multilevel models were used to analyze patient-reported sleep difficulty.

Results
Reporting of mild to severe sleep difficulties ranged from 10% to 43%. Sleep scores fluctuated greatly over the course of palliative care. While improvement in patients’ clinical status was associated with less sleep difficulty, the relationship was not clear when patients deteriorated. Worsening of sleep difficulty was associated with higher psychological distress (P &lt; .0001), greater breathing problems (P &lt; .05) and pain (P &lt; .05), and higher functional status (P &lt; .001) at the beginning of care.

Conclusions
Sleep difficulty is prevalent but fluctuates widely in patients with CNS cancers receiving palliative care. A better-tailored sleep symptom assessment may be needed for this patient population. Early interventions targeting psychological distress, breathing symptoms, and pain for more functional patients should be explored to see whether it reduces sleep difficulties late in life.
A molecular line survey toward the nearby galaxies NGC 1068, NGC 253, and IC 342 at 3 mm with the Nobeyama 45 m radio telescope: The data
Authors: Takano Shuro , Nakajima Taku , Kohno Kotaro 
Published: February 2019

Abstract
We present observational data of a molecular line survey toward the nearby galaxies NGC 1068, NGC 253, and IC 342 at wavelengths of 3 mm (∼85–116 GHz) obtained with the Nobeyama 45 m radio telescope. Regarding IC 342, a line survey with high spectral resolution in the 3 mm region was reported for the first time. NGC 1068 is a nearby gas-rich galaxy with X-rays from an active galactic nucleus (AGN), and NGC 253 and IC 342 are nearby gas-rich galaxies with prototypical starbursts. These galaxies are useful for studying the impacts of X-rays and ultraviolet radiation on molecular abundances. The survey was carried out with a resulting rms noise level of a few mK ($T\rm {_A^*}$). As a result we could obtain almost complete data of these galaxies in the 3 mm region: we detected 19–23 molecular species, depending on the galaxies, including several new detections (e.g., cyclic-C3H2 in IC 342). We found that the intensities of HCN, CN, and HC3N relative to 13CO are significantly strong in NGC 1068 compared with those in NGC 253 and IC 342. On the other hand, CH3CCH was not detected in NGC 1068. We obtained these results with the narrow beam (${15{^{\prime\prime}_{.}}2}$–${19{^{\prime\prime}_{.}}1}$) of the 45 m telescope, among single-dish telescopes, and in particular selectively observed molecular gas close to the circumnuclear disk (CND) in NGC 1068. The present line intensities in NGC 1068 were compared with those obtained with the IRAM 30 m radio telescope already reported. As a result, the intensity ratio of each line was found to have information on the spatial distribution. Our observations revealed the line intensities and stringent constraints on the upper limit for the three galaxies with such a narrow beam; consequently, the present data will be a basis for further observations with high spatial resolution.