bluuebunny/crossref_metadata_2025_split huggingface dataset:
The COSMIC/FORMOSAT-3 Radio Occultation Mission after 12 Years: Accomplishments, Remaining Challenges, and Potential Impacts of COSMIC-2
Authors: Ho Shu-peng , Anthes Richard A. , Ao Chi O. , Healy Sean , Horanyi Andras , Hunt Douglas , Mannucci Anthony J. , Pedatella Nicholas , Randel William J. , Simmons Adrian , Steiner Andrea , Xie Feiqin , Yue Xinan , Zeng Zhen 
Published: September 2019

AbstractLaunched in 2006, the Formosa Satellite Mission 3–Constellation Observing System for Meteorology, Ionosphere and Climate (FORMOSAT-3/COSMIC) was the first constellation of microsatellites carrying global positioning system (GPS) radio occultation (RO) receivers. Radio occultation is an active remote sensing technique that provides valuable information on the vertical variations of electron density in the ionosphere, and temperature, pressure, and water vapor in the stratosphere and troposphere. COSMIC has demonstrated the great value of RO data in ionosphere, climate, and meteorological research and operational weather forecasting. However, there are still challenges using RO data, particularly in the moist lower troposphere and upper stratosphere. A COSMIC follow-on constellation, COSMIC-2, was launched into equatorial orbit in 2019. With increased signal-to-noise ratio (SNR) from improved receivers and digital beam steering antennas, COSMIC-2 will produce at least 5,000 high-quality RO profiles daily in the tropics and subtropics. In this paper, we summarize 1) recent (since 2011 when the last review was published) contributions of COSMIC and other RO observations to weather, climate, and space weather science; 2) the remaining challenges in RO applications; and 3) potential contributions to research and operations of COSMIC-2.
Enhancing ACIS Maps: Increasing Usability through a GIS Portal
Authors: Umphlett Natalie A. , Pettee Warren , Sorensen William , Stiles Crystal J. 
Published: September 2019

AbstractSince 2003, the High Plains Regional Climate Center (HPRCC) has been producing the Applied Climate Information System (ACIS) Climate Summary Maps for users all across the country. The maps allow users to quickly and easily assess climate conditions for various time scales that range from weeks to months to years, as well as spatial scales varying from state to regional and national levels. Although popular among the climate and drought monitoring community, the maps are utilized by a number of sectors, including academia, agriculture, government, resource management, and utilities. Over the years, the HPRCC has received a number of requests from users looking to customize and enhance the ACIS Climate Summary Maps. With funding provided by the National Integrated Drought Information System (NIDIS), the Center is now able to produce and distribute GIS versions of the ACIS Climate Summary Maps. Maps in GIS formats help to meet user needs by allowing them the opportunity to create custom color scales, choose specific regions, and combine information from various sources with the data available in the mapped products. The GIS data are available via a GIS Portal and GeoServer, which are accessible from the HPRCC website.
Epidemiology of alcohol-related accidental death in Tokyo Metropolitan area (2015)
Authors: Suzuki Hideto , Tanifuji Takanobu , Kimura Satoko , Fukunaga Tatsushige 
Published: September 2019

Background Alcohol consumption may be a risk factor for accidental deaths; however, characteristics of alcohol-related deaths are unclear. We investigated characteristics of alcohol-related accidental deaths to facilitate target strategies. Methods In this article, 1060 cases of accidental deaths examined by the Tokyo Medical Examiner’s Office (2015) were divided into two groups: deceased individuals who drank alcohol (alcohol; n = 212) and those who did not (control; n = 848). Age, sex, alcohol consumption patterns, and manners/causes of deaths were compared. Places where individuals in the alcohol group met with an accident, and their blood alcohol concentration was assessed. Results Lower mean age (60.5 vs. 73.7 years) and a higher male ratio (75.9% vs. 58.5%) were observed in the alcohol group. Daily alcohol consumption was more common in the alcohol group (70.8% vs. 13.4%). Falling was the leading cause of death in the alcohol group, but without a significant difference (alcohol: 31.6%, control: 30.4%). Incidence rates of drowning (22.2% vs. 7.9%) and poisoning (11.3% vs. 2.0%) were significantly higher in the alcohol group. The mean blood alcohol concentration was 1.6 mg/mL. Of the total alcohol-related accidents, 60.8% occurred at home. Falling down the stairs was the primary type of falling, and majority of drownings occurred in a bathtub. Conclusion Male habitual drinkers (middle-aged to older adults) should be targeted to prevent alcohol-related accidental deaths. More than 50% of deaths occurred at home and care should be taken when performing daily activities, including using stairs and while bathing.
Validity and reliability of Food–Mood Questionnaire (FMQ)
Authors: Begdache Lina , Marhaba Rani , Chaar Maher 
Published: September 2019

Background: The need for short and validated questionnaires to evaluate dietary patterns (DPs) and mental distress in clinical and research settings is increasing. Aim: The purpose of this study was to develop and validate a Food–Mood Questionnaire (FMQ) to assess DPs in relation to mental distress. Method: A standard validation protocol that included item development, pilot–testing, test–retesting, and a series of statistical validation analyses was used. Content, face, internal, construct and external validity as well as reliability were confirmed. Content and face validity were evaluated qualitatively. Results: Principal component analysis (PCA) for construct validity generated five sub-scales which reflected internal consistency (Cronbach’s α > 0.70) and internal reliability (intraclass correlation coefficient ranged between 0.619 and 0.884; p < 0.01; confidence interval 95%). External validity was also confirmed. A total of 563 participants from four different continents completed the survey online. PCA generated five different subscales. Mental distress was associated with regular consumption of fast-food, a DP known to induce anxiety and depression. Conclusion: The FMQ is a validated and a reliable tool with many potential applications that could be used with prophylactic and therapeutic approaches.
Novel surgical technique and efficacy analysis of donor pancreas preparation without vascular reconstruction in pancreas transplantation
Authors: Liao Wen-wei , Ling Xiang-chao , Zhang Cheng , Liu Fu-rong , Zhu Xiao-feng , He Xiao-shun , Hu An-bin 
Published: September 2019

Objective Because of the complicated blood supply and vascular structure of the pancreas, blood vessel reconstruction and reshaping are generally required during pancreas transplantation. We modified the vascular preparation procedure for the donor pancreas (i.e., no vascular reconstruction was performed) based on experiences in our department and in other domestic and international transplantation centers. Methods Twelve donor pancreas preparations without vascular reconstruction were performed. The patch (Carrel patch), celiac trunk, and superior mesenteric artery were preserved as arterial inflow channels for the donor pancreas. The common hepatic artery and the gastroduodenal artery were transected at a site 0.5 cm away from the bifurcation. The bifurcated portion was preserved for the donor liver. The stumps of the gastroduodenal artery and common hepatic artery were then ligated. The portal vein was transected in the middle of the hepatoduodenal ligament during separation of the liver and pancreas. The partial portal vein preserved with the pancreas was used as the outflow channel of the donor pancreas. Results The transplanted pancreas functioned well in the recipients, and no vascular complications were reported. Conclusion The overall efficacy of pancreas transplantation without vascular reconstruction has been improved.
Surgical treatment of trapezius palsy: A systematic review
Authors: Elsawi Rawaan S , Vancolen Seline Y , Horner Nolan S , Khan Moin , Alolabi Bashar 
Published: September 2019

Background Trapezius palsy results from injury to the spinal accessory nerve. The condition presents with loss of shoulder abduction, pain, and winging of the scapula. Surgical treatment may improve functional outcomes and quality of life. Purpose The purpose of this study was to report and evaluate the clinical outcomes following surgical management of trapezius palsy. Study design Systematic review. Methods The electronic databases EMBASE, MEDLINE, and PubMed were searched for studies and relevant data were abstracted. Only studies reporting on outcomes after the surgical treatments of trapezius palsy were included. Results A total of 10 studies including 192 patients were included in this review. All surgical interventions resulted in improved function and pain reduction. Patients reported high satisfaction (90–92%) following nerve reconstruction or the Eden–Lange procedure, in comparison to neurolysis. The most common procedure reported was the Eden–Lange muscle transfer (32% reported cases) demonstrating the highest patient satisfaction rates with low complication rate of 7.7%. Conclusion Patients failing conservative treatment report good outcomes following surgical treatment of trapezius palsy. All reported surgical procedures demonstrate reduction in pain the best results from the Eden–Lange muscle transfer. Further high-quality comparative studies are required to make definitive conclusions regarding the comparative efficacy of each surgical procedure.
Mitigation of T-cell dependent immunogenicity by reengineering factor VIIa analogue
Authors: Jankowski Wojciech , McGill Joseph , Lagassé H. A. Daniel , Surov Stepan , Bembridge Gary , Bunce Campbell , Cloake Edward , Fogg Mark H. , Jankowska Katarzyna I. , Khan Abdul , Marcotrigiano Joseph , Ovanesov Mikhail V. , Sauna Zuben E. 
Published: September 2019

AbstractVatreptacog alfa (VA), a recombinant activated human factor VII (rFVIIa) variant with 3 amino acid substitutions, was developed to provide increased procoagulant activity in hemophilia patients with inhibitors to factor VIII or factor IX. In phase 3 clinical trials, changes introduced during the bioengineering of VA resulted in the development of undesired anti-drug antibodies in some patients, leading to the termination of a potentially promising therapeutic protein product. Here, we use preclinical biomarkers associated with clinical immunogenicity to validate our deimmunization strategy applied to this bioengineered rFVIIa analog. The reengineered rFVIIa analog variants retained increased intrinsic thrombin generation activity but did not elicit T-cell responses in peripheral blood mononuclear cells isolated from 50 HLA typed subjects representing the human population. Our algorithm, rational immunogenicity determination, offers a broadly applicable deimmunizing strategy for bioengineered proteins.
Immunoadsorption and autologous transplantation for life-threatening primary antiphospholipid syndrome
Authors: Angelillo-Scherrer Anne , Mansouri Taleghani Behrouz , Förger Frauke , Baerlocher Gabriela M. , Pabst Thomas , Pöllinger Alexander , Banz Yara , Geiser Thomas , Kremer Hovinga Johanna A. , Rovó Alicia 
Published: September 2019

Key Points
Reduction of APL antibodies by immunoadsorption may be a lifesaving therapy for the management of DAH with high titer of APL antibodies. Autologous HSCT may be a valid treatment option in patients with primary APS and no response to standard immunosuppressive therapy.
Reduction in the utilization of prednisone or methotrexate in Canadian claims data following initiation of etanercept in pediatric patients with juvenile idiopathic arthritis
Authors: Khraishi Majed , Millson Brad , Woolcott John , Jones Heather , Marshall Lisa , Ruperto Nicolino 
Published: September 2019

Abstract

Background
In adult patients with arthritis, use of the tumor necrosis factor (TNF) inhibitor etanercept (ETN) is often associated with a reduction in the utilization of co-medications, particularly steroids. Comparatively little is known about the utilization of co-medications when ETN is initiated in pediatric patients with juvenile idiopathic arthritis (JIA).

Methods
This study analyzed Canadian longitudinal claims level data spanning January 2007 to April 2017. Data were collated from the IQVIA Private Drug Plan, Ontario Public Drug Plan, and the Quebec Public Drug Plan (Régie de l’assurance maladie du Québec) databases. Patients < 18 years of age were indexed when filling a prescription for ETN between January 2008 and January 2016. Those who met the inclusion and exclusion criteria were assessed for methotrexate (MTX), and prednisone (PRD) use in the 6 months prior to and 12 months following initiation of ETN.

Results
Longitudinal claims data for 330 biologic-naive pediatric patients initiating ETN therapy were included. The majority of patients were female (67%), aged 10–17 years (64%), and with a drug history consistent with JIA (96%). Most patients were from Quebec (36%) or Ontario (33%). Dosing of ETN was weight-based with a mean dosage over the first year of 31 mg per week. ETN dosing was relatively consistent over the first year. In total, 222 (67%) patients did not use MTX and 223 (68%) did not use PRD before or after starting ETN. A total of 17% (18/103) of MTX-treated and 50% (46/92) of PRD-treated patients discontinued use of those medications upon initiation of ETN treatment. In patients continuing MTX or PRD, significant reductions in the weekly dosage from 14.3 to 6.8 mg per week for MTX and from 56 to 23 mg per week for PRD were observed (P < 0.01).

Conclusions
This study of Canadian claims-level data is the first large prespecified analysis of co-medication utilization following the initiation of ETN therapy in pediatric patients. A decline in both MTX and PRD use and dosage was observed and may be associated with benefits related to safety, tolerability, and overall healthcare costs.
Postpartum depression and associated factors among mothers in Bahir Dar Town, Northwest Ethiopia
Authors: Abebe Amsale , Tesfaw Getachew , Mulat Haregewoine , Hibdye Getahun , Yohannes kalkidan 
Published: September 2019

Abstract

Background
Postpartum depressive symptoms are the occurrence of major depressive episode within 4 weeks following delivery. Globally, 10%–20% of mothers suffer from depressive symptoms during their postpartum course. Therefore, assessing postpartum depressive symptoms has a pivotal role in ensuring that their mental health needs are met.

Methods
An institution-based cross-sectional study was conducted including 511 mothers coming for postnatal care service in public health centers in Bahir Dar Town. Data were collected using a pre-tested, structured, and interviewer-administered questionnaire, while the Edinburgh Postnatal Depression Scale (EPDS) was used to assess individuals’ depressive symptoms. The systematic random sampling technique was employed to recruit the study participants. Adjusted odds ratio with a 95% confidence interval (CI) was used to declare the statistical significance of the factors.

Results
Postpartum depressive symptoms among mothers were found to be 22.1 (95%, CI 18.6%, 25.8%). In multivariate logistic regression, stressful life events (AOR = 4.46, 95% CI 2.64, 7.54), domestic decision making (AOR = 4.26, 95% CI 2.54, 7.14), unplanned pregnancy (AOR = 1.86, 95% CI 1.02, 3.41), partner violence (AOR = 3.16, 95% CI 1.76, 5.67), and hospitalization of their babies (AOR = 2.24, 95% CI 1.17, 4.310) were factors significantly associated with postpartum depressive symptoms.

Conclusions
Postpartum depressive symptoms among mothers were common in the study area. Stressful life events, lack of empowerment in domestic decision making, intimate partner violence, unplanned pregnancy, and hospitalization of their baby were factors significantly associated with postpartum depression. The Ministry of Health needs to give training on how to screen postpartum depressive symptoms among mothers, and interventions that would address the above factors would benefit in tackling further complications.
Mental health problems of children and adolescents, with and without migration background, living in Vienna, Austria
Authors: Gutmann Maria Teresa , Aysel Metin , Özlü-Erkilic Zeliha , Popow Christian , Akkaya-Kalayci Türkan 
Published: September 2019

Abstract

Background
Compared to their indigenous peers, migrant children and adolescents are at increased risk for mental health problems. The aim of our study was to compare psychological disorders of children and adolescents with Turkish migration background and their native Austrian peers.

Methods
We analysed 302 children and adolescents aged between 7 and 18 years. The sample consisted of 100 Austrian and 100 Turkish outpatients with mental health problems, and 102 healthy controls, 52 with Austrian and 50 with Turkish background, recruited from various Viennese local child and youth centres.

Results
Native patients had more frequently externalizing problems (42.1%) compared to the Turkish-speaking sample (28%). However, in the control group, Turkish-speaking children and adolescents had higher levels of internalizing, depressive and anxiety symptoms compared to their native peers.

Conclusions
We found noticeable differences in psychological problems among children and adolescents with and without migration background. We assume that migration-related stress factors are responsible for these differences. Also, children and adolescents with migration background seek for psychological help less frequently than their indigenous peers.
Chemical modification of Bombyx mori silk fibers with vinyl groups for thiol-ene click chemistry
Authors: Zhang Xiaoning , Liang Jianwei , Chen Zhenyu , Donley Carrie , Liu Yuling , Cheng Guotao 
Published: September 2019

Abstract
Natural Bombyx mori silk fibroin (SF) fibers were modified with 2-methacryloyloxyethyl isocyanate (MOI) first for the introduction of vinyl groups. Then, 1H,1H,2H,2H-perfluorodecanethiol was grafted onto the SF fibers via thiol-ene click chemistry using ultraviolet light. The formations of MOI-modified and PFDT-grafted SF fibers were analyzed using Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, respectively. The morphology of samples was also revealed by a scanning electron microscope. In addition, differential scanning calorimetry results demonstrated that SF fibers did not show significant change in thermal behavior, regardless of the chemical modification. To confirm the cytotoxicity of the prepared SF fibers, MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay was performed, and no toxicity was observed with PFDT-grafted SF fibers. The results also showed that PFDT-grafted SF fibers exhibited good antifouling properties when Chlorella vulgaris (C. vulgaris) was selected as a model for algal cells adhesion experiment.
Preventive efficacy of oral moxidectin at various doses and dosage regimens against macrocyclic lactone-resistant heartworm (Dirofilaria immitis) strains in dogs
Authors: McTier Tom L. , Six Robert H. , Pullins Aleah , Chapin Sara , Kryda Kristina , Mahabir Sean P. , Woods Debra J. , Maeder Steven J. 
Published: September 2019

Abstract

Background
Moxidectin has previously shown limited efficacy (≤ 44.4%) against confirmed macrocyclic lactone (ML)-resistant Dirofilaria immitis strains at 3 µg/kg after single and multiple oral dosages. Three studies were conducted to evaluate higher oral moxidectin doses for efficacy against confirmed ML-resistant D. immitis strains.

Methods
Dogs were inoculated with 50 D. immitis L3 and randomly allocated to treatments. Study 1: 6 groups of dogs (n = 8) were inoculated with JYD-34 (Day − 30) and treated as follows: T01, negative control; T02–T05, moxidectin at 3, 6, 12 or 24 µg/kg, respectively, on Day 0 only; T06, moxidectin at 3 µg/kg on Days 0, 30 and 60. Study 2: 10 groups of dogs (n = 5) were inoculated (Day − 30) with either JYD-34 (T01, T03–05) or ZoeLA (T02, T06–T10) and treated as follows: T01 and T02, negative controls; T03–T05, moxidectin at 24, 40 or 60 µg/kg, respectively, on Days 0, 28 and 56; T06 and T09, moxidectin at 3 or 60 µg/kg on Day 0 only; T07, T08 and T10, moxidectin at 24, 40 or 60 µg/kg, respectively, on Days 0, 28 and 56. Study 3: 5 groups of dogs (n = 5) were inoculated with ZoeMO (Day − 28) and treated as follows: T01, negative control; T02, moxidectin at 3 µg/kg moxidectin on Day 0 only; T03–T05, moxidectin at 24, 40 or 60 µg/kg, respectively, on Days 0, 28 and 56. All dogs were necropsied for adult heartworm recovery ~ 4–5 months post-inoculation.

Results
All moxidectin-treated dogs showed significantly lower worm counts than controls. The efficacy of moxidectin administered once at 3 µg/kg was 19% (JYD-34), 44.4% (ZoeLA) and 82.1% (ZoeMO). Increasing both the dose and the number of dosages of moxidectin improved efficacy, with 100% protection obtained using three dosages of moxidectin at either 40 µg/kg (JYD-34, ZoeMO) or 60 µg/kg (ZoeLA). Three dosages of 24 µg/kg were also highly effective, providing ≥ 98.8% efficacy for all three strains.

Conclusions
Increasing both the dose and number of consecutive monthly dosages of moxidectin improved the efficacy against ML-resistant heartworms. Based on these data and other technical considerations, the 24 µg/kg dose was considered the optimal dose for further commercial development.
The balance model for teaching linear equations: a systematic literature review
Authors: Otten Mara , Van den Heuvel-Panhuizen Marja , Veldhuis Michiel 
Published: September 2019

AbstractThis paper reports a systematic literature review of the balance model, an often-used aid to teach linear equations. The purpose of the review was to reportwhysuch a model is used,whattypes of models are used, andwhenthey are used. In total, 34 peer-reviewed journal articles were analyzed, resulting in a comprehensive overview of described rationales for using the balance model, its appearances, situations in which it was used, and the gained learning outcomes. Some trends appeared about how rationales, appearances, situations, and learning outcomes are related. However, a clear pattern could not be identified. Our study shows that this seemingly simple model actually is a rather complex didactic tool of which in-depth knowledge is lacking. Further systematic research is needed for making informed instructional decisions on when and how balance models can be used effectively for teaching linear equation solving.