bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microstructure and flexural strength of the Y:TZP/BG composite
Authors: de Paula Miranda Ranulfo Benedito , Borges Roger , Marchi Juliana , de Lima Nelson Batista , Cesar Paulo Francisco 
Published: June 2019

AbstractThe addition of bioactive glasses to a Y:TZP matrix represents a feasible alternative to provide bioactivity to this material and optimize osseointegration. This work evaluated the effect of the BG concentration (0 and 10 wt%) and the sintering temperature (1200°C and 1300°C) on the microstructure, relative density, and flexural strength of the composite Y:TZP/BG. The Y:TZP and Y:TZP/BG powders were uniaxially pressed and sintered at 1200°C or 1300°C for 1 h. The microstructure was characterized by X‐ray diffraction analysis, scanning electron microscopy, and energy‐dispersive X‐ray Spectroscopy. Relative density was calculated from density values obtained using the Archimedes’ principle. For the flexural strength, specimens (n = 6) were fractured in a biaxial flexural setup using a piston‐on‐three‐balls fixture in a universal testing machine. Bioactivity test was performed in simulated body fluid solution. The results suggested that BG addition decreased the grain size of the composite, increased porosity and caused a significant decrease in the relative density and flexural strength. Crystalline phases of calcium stabilized cubic zirconia and sodium zirconium silicate were formed after the addition of BG. Finally, it was concluded that composite specimens sintered at 1300°C showed the highest density values and larger grains compared to those sintered at 1200°C.
Are new variants of psoriasis therapy (IL‐17 inhibitors) safe?
Authors: Wcisło‐Dziadecka Dominika , Kaźmierczak Agata , Grabarek Beniamin , Zbiciak‐Nylec Martyna , Brzezińska‐Wcisło Ligia 
Published: June 2019

AbstractPsoriasis is a chronic, recurrent, inflammatory, and proliferative skin disease. Its etiology has not yet been fully assessed, but undoubtedly it is a multifaceted disease. The key role in its pathomechanism is played by genetic, immunologic, and environmental factors and stress. If traditional methods of psoriasis treatment (phototherapy, methotrexate, retinoids, cyclosporine A) fail, we reach for the following biopharmaceuticals – infliximab, etanercept, adalimumab, or ustekinumab. However, genetic engineering progress discovers new possibilities – the pending clinical trials involve IL‐17, IL‐23 antagonists, PDE4 and ‐3 and ‐1. Psoriasis etiopathogenesis mainly involves the IL‐17A, IL‐17F, and IL‐17A/F subtypes, which affect the keratinocytes. The biological therapy molecularly oriented with the antagonists of interleukin 17 is based mainly on the influence onto the cytokine in the manner that prevents it from binding with the receptor. Three biopharmaceuticals are currently under third phase studies: two fully humanized antibodies neutralizing IL‐17 – ixekizumab and secukinumab, and one human monoclonal antibody, brodalumab. The below work will be devoted to the analysis of possible undesirable symptoms, which were observed during the studies. We will try to review the latest literature concerning the most important clinical trials conducted in many centers.
14‐Month‐olds anticipate others’ actions based on their belief about an object's identity
Authors: Buttelmann Frances , Kovács Ágnes Melinda 
Published: June 2019

AbstractPast research has accumulated evidence regarding infants’ false‐belief understanding, measuring their gaze patterns or active helping behaviors. However, the underlying mechanisms are still debated, specifically, whether young infants can compute that others represent the world under a certain aspect. Such performance requires holding in mind two representations about the same object simultaneously and attributing only one to another person. While 14‐month‐olds can encode an object under different aspects when forming first‐person representations, it is unclear whether infants at this very age could also predict others’ behavior based on their beliefs about an object's identity. Here, we investigate this question in a novel eye‐tracking‐based unexpected‐identity task. We measured 14‐month‐olds’ anticipatory looks combined with their looking time, using a violation‐of‐expectation paradigm. Results show that 14‐month‐olds look longer to an actor's reach that is incongruent with her false belief about the identity of an object compared to a congruent reach. Furthermore, infants correctly anticipated the actor's reach based on her false belief. Thus, as soon as infants represent dual identities they can integrate them in belief attributions and use them for consequent behavioral predictions. Such data provide evidence for the flexibility of false‐belief attributions and support proposals arguing for infants’ rich theory‐of‐mind abilities.
An overview of a biopsychosocial model of epigenetics and pain catastrophizing
Authors: Brecht Danielle M. , Gatchel Robert J. 
Published: June 2019

AbstractIn an earlier Special Issue in the Journal of Applied Biobehavioral Research (JABR), Gatchel (Journal of Applied Biobehavioral Research, 2017, 22[1], e12088) addressed the construct of pain catastrophizing (PC). The present article is meant to extend those reviews within a biopsychosocial context, as well as update recent research on PC with a specific concentration on genetic factors. An overview of biological factors as they relate to PC and epigenetics are reviewed first (brain areas associated with pain and how they adapt neurochemically to chronic noxious stimuli, polymorphism of various genes, etc.), proceeded by the discussion of psychological (depression, anxiety, and the genomic link to neuroticism) and social influences (reason people engage in PC, age's impact on neuronal restructuring) as they corroborate the argument of PC's link to genetic factors. Finally, this article concludes by providing future directions for research concerning PC such as examining the efficacy of Pain Neurobiology Education, as well as gene therapy.
Predictors of freedom from atrial arrhythmia recurrence after cryoballoon ablation for persistent atrial fibrillation: A multicenter study
Authors: Reissmann Bruno , Plenge Tobias , Heeger Christian‐Hendrik , Schlüter Michael , Wohlmuth Peter , Fink Thomas , Rottner Laura , Tilz Roland Richard , Mathew Shibu , Lemeš Christine , Maurer Tilman , Lüker Jakob , Sultan Arian , Bellmann Barbara , Goldmann Britta , Ouyang Feifan , Kuck Karl‐Heinz , Metzner Andreas , Steven Daniel , Rillig Andreas 
Published: June 2019

AbstractAimsWe sought to assess (1) clinical outcomes of second‐generation cryoballoon (CB) ablation for persistent atrial fibrillation (AF), and (2) the association of baseline and procedural covariates with atrial arrhythmia recurrence (AAR) after ablation.MethodsA total of 135 patients (63 ± 11 years, 96 men [71%]) with persistent AF underwent CB ablation at three experienced electrophysiology centers. Freedom from AAR was estimated with the Kaplan‐Meier method. A Cox proportional‐hazards model was used to estimate the effects of baseline and procedural covariates on the likelihood of AAR.ResultsFreedom from AAR at 6, 12, and 18 months was estimated at 91% (95% confidence interval [CI] 86%‐96%), 75% (95% CI, 67%‐83%), and 53% (95% CI, 43%‐65%), respectively. The presence of an implantable cardiac device (Hazard ratio [HR] 3.09; 95% CI, 1.37‐7.00; P = .007), a left atrial (LA) diameter > 50 mm (HR 1.69; 95% CI, 1.02‐2.79; P = .043), and absence of antiarrhythmic drug (AAD) therapy before the ablation procedure (HR 3.12; 95% CI, 1.72‐5.64; P < .001) were associated with AAR. A trend toward an increased risk of AAR was revealed for women (HR 1.73; 95% CI, 0.96‐3.11; P = .069).ConclusionsCB ablation for persistent AF resulted in freedom from AAR about that reported for RF ablation. The presence of an implantable cardiac device, LA size, and absence of AAD therapy at baseline were associated with the risk of AAR.
Use of a novel bipolar sealer device in pocket infections: A case series
Authors: Schaller Robert D. , Santangeli Pasquale , Tomczuk Liza , Frankel David S. 
Published: June 2019

AbstractBackgroundCardiac implantable electronic device pocket infections require complete system removal. However, postoperative bleeding and hematoma can occur after extensive debridement and an optimal management strategy has yet to be defined.MethodsFollowing system removal and debridement, all pockets were treated with the Aquamantys bipolar sealer until hemostasis of the underlying tissue was achieved. Clinical characteristics, sealer application time, and postoperative outcomes were analyzed.ResultsThirteen consecutive patients were included with an average age of 61.6 years and 8/13 were male. One patient had both pocket infection and systemic bacteremia. Explanted devices included three pacemakers, nine transvenous implantable cardioverter‐defibrillators (ICD), and one subcutaneous ICD. The average number of leads extracted was 2.08 ± 1.04 with a median lead dwell time of 75 months (range, 1‐265). Pocket tissue culture yielded Streptococcus anginosus (1), Pseudomonas aeruginosa (2), Staphylococcus epidermidis (1), Staphylococcus aureus (1), and no growth (8). Average time using the Aquamantys was 5.6 ± 2.75 minutes per patient. Twelve out of thirteen pockets were closed by primary intention with one pocket packed and left to heal via secondary intention. A Jackson‐Pratt drain was used in three patients and removed within 3 days. There were no hematomas noted during the acute hospitalization or during follow up and all of the wounds healed completely.ConclusionsUse of a novel bipolar sealing device in lieu of traditional electrocautery provided rapid and durable hemostasis with the ability to close almost all of the pockets via primary intention.
Supra‐alveolar attachment gain in the treatment of combined intra‐suprabony periodontal defects by non‐incised papillae surgical approach
Authors: Moreno Rodríguez Jose A. , Ortiz Ruiz Antonio J. , Caffesse Raúl G. 
Published: June 2019

AbstractAimTo assess the effectiveness of non‐incised papillae surgical approach (NIPSA) in periodontal reconstructive surgery of combined intra‐suprabony defects.Materials and MethodsPatients with deep periodontal defects treated with NIPSA (n = 20) were analysed. Defects were treated with enamel matrix derivative plus xenograft. Clinical outcomes were assessed before surgery and at 12 months. Wound closure was assessed one week post‐surgery. Supra‐alveolar attachment gain (SUPRA‐AG) was recorded at 12 months post‐surgery.ResultsNon‐incised papillae surgical approach showed significant improvements in clinical attachment gain (5.9 ± 2.38 mm; p < 0.001), recession reduction (0.25 ± 0.44; p < 0.05) and tip of the papillae coronal displacement (0.4 ± 0.5; p < 0.05). It also showed complete wound closure of the apical mucosal incision in the 85% of the cases, with no interproximal tissue necrosis. SUPRA‐AG (1.9 ± 1.74) showed a positive tendency, associated with complete intrabony defect resolution.ConclusionsNon‐incised papillae surgical approach promoted primary intention healing, wound stability and space provision for optimal periodontal reconstruction, preserving supra‐alveolar soft tissue integrity.
Effects of electronic medical records on patient safety culture: The perspective of nurses
Authors: Özer Özlem , Şantaş Fatih 
Published: June 2019

AbstractObjectivesThis study investigates the effects of nurses' views regarding electronic medical records on patient safety culture.MethodsThe implementation part of the study was conducted with nurses working in seven state hospitals in the Burdur province of Turkey. The data were collected between 15 March and 20 April 2018. Correlation and multiple regression analyses were performed to evaluate the relationships among the variables in the study. In addition, descriptive analyses (mean, standard deviation) and Cronbach α coefficients of reliability of the scales were also used.ResultsThe results of the analyses revealed that control variables (gender, educational level, age, etc) and all dimensions of electronic medical records affected all three dimensions of patient safety culture. The control variables and all dimensions of electronic medical records explained 41% of the total variance in perceptions of process, 42.5% of the total variance in management support for patient safety, and 27.9% of the total variance in perceptions of safety.DiscussionThis study provides insight concerning the effects of nurses' views of electronic medical records on patient safety culture. The results of the study reveal that nurses' views of electronic medical records affect the perception of patient safety culture positively.ConclusionsIt is recommended that further studies be conducted on topics such as the use of medical records and the development of patient safety. Health care managers should encourage nurses to undergo training and educational efforts on electronic medical records and patient safety.
Fish photobacteriosis—The importance of rapid and accurate identification of Photobacterium damselae subsp. piscicida
Authors: Pečur Kazazić Snježana , Topić Popović Natalija , Strunjak‐Perović Ivančica , Florio Daniela , Fioravanti Maria , Babić Sanja , Čož‐Rakovac Rozelindra 
Published: June 2019

AbstractMALDI‐TOF MS was tested for the identification of Photobacterium damselae subsp. piscicida on isolates grown on two media, cultured at three incubation times and applied on the target plate by the direct sample spotting (DS), by the on‐target extraction (OTE) and by the full extraction (FE) method, in triplicates. The identification of samples grown on blood agar (BA) outperformed identification on tryptic soya agar (TSA) by 0.64% for DS and OTE. The OTE gave the highest scores in both culture media, all incubation times and replicates. Reliable 24‐hr species identification was 61.54%, 84.61% and 53.85% for samples grown on TSA and identified by DS, OTE and FE, respectively. For isolates grown on BA, they were 76.92%, 96.15% and 30.77%, respectively. When identified by OTE, the 48‐hr identification was 93.58%, but for 72 hr declined to 71.79%. The reliable identification with the highest score from the first measurement was 100% only for OTE from BA (24 hr), whereas OTE from TSA gave 84.61% (24 hr), 76.92% (48 hr) and 84.61% (72 hr). The reliable MALDI‐TOF MS identification of Ph. damselae subsp. piscicida is incubation time, media, target plate preparation and replicate‐dependent.
From the urban metabolism to the urban immune system
Authors: Bristow David N. , Mohareb Eugene A. 
Published: June 2019

AbstractUrban areas face mounting risks from many sources. Cities pursue myriad tactics to resist, recover from and adapt to shocks and stresses, but little is known about how these approaches relate across the scales of a city nor how cities compare in their abilities. Part of the challenge in addressing these gaps is that the risk to cities is typically studied with an emphasis on one or a few hazards or through the lens of a singular sector. This paper proposes a framework, dubbed the Urban Immune System (UIS) to coalesce and expand industrial ecology research on urban risk management. In the same way that Urban Metabolism (UM) is a unifying framework for urban environmental sustainability, UIS can be a unifying framework for urban resilience, especially related to climate change. Herein, UIS is defined, its many capabilities are dissected and linked to disparate studies; and opportunities for application of the concept are provided. The paper concludes by examining the relationship between UIS and climate change and by identifying those attributes of the UIS that are expected to be of increasing importance under climate change.
Cardiac autonomic dynamics during sleep are lost in patients with TIA and stroke
Authors: Tobaldini Eleonora , Proserpio Paola , Oppo Valentina , Figorilli Michela , Fiorelli Elisa M. , Manconi Mauro , Agostoni Elio C. , Nobili Lino , Montano Nicola , Horvath Thomas , Bassetti Claudio L. 
Published: June 2019

AbstractIschaemic stroke is accompanied by important alterations of cardiac autonomic control, which have an impact on stroke outcome. In sleep, cardiac autonomic control oscillates with a predominant sympathetic modulation during REM sleep. We aimed to assess cardiac autonomic control in different sleep stages in patients with ischaemic stroke. Forty‐five patients enrolled in the prospective, multicentre SAS‐CARE study but without significant sleep‐disordered breathing (apnea–hypopnea index < 15/hr) and without atrial fibrillation were included in this analysis. The mean age was 56 years, 68% were male, 76% had a stroke (n = 34, mean National Institutes of Health Stroke Scale [NIHSS] score of 5, 11 involving the insula) and 24% (n = 11) had a transitory ischaemic attack. Cardiac autonomic control was evaluated using three different tools (spectral, symbolic and entropy analysis) according to sleep stages on short segments of 250 beats in all patients. Polysomnographic studies were performed within 7 days and 3 months after the ischaemic event. No significant differences in cardiac autonomic control between sleep stages were observed in the acute phase and after 3 months. Predominant vagal modulation and decreased sympathetic modulation were observed across all sleep stages in ischaemic stroke involving the insula. Patients with ischaemic stroke and transitory ischaemic attack present a loss of cardiac autonomic dynamics during sleep in the first 3 months after the ischaemic event. This change could represent an adaptive phenomenon, protecting the cardiovascular system from the instabilities of autonomic control, or a risk factor for stroke, which precedes the ischaemic event.
Understanding the effect of repeated administration of meloxicam on feline renal cortex and medulla: A lipidomics and metabolomics approach
Authors: Rivera‐Velez Sol M. , Broughton‐Neiswanger Liam E. , Suarez Martin A. , Slovak Jennifer E. , Hwang Julianne K. , Navas Jinna , Leung Amy W. S. , Piñeyro Pablo E. , Villarino Nicolas F. 
Published: June 2019

AbstractRepeated administration of meloxicam can cause kidney damage in cats by mechanisms that remain unclear. Metabolomics and lipidomics are powerful, noninvasive approaches used to investigate tissue response to drug exposure. Thus, the objective of this study was to assess the effects of meloxicam on the feline kidney using untargeted metabolomics and lipidomics approaches. Female young‐adult purpose‐breed cats were allocated into the control (n = 4) and meloxicam (n = 4) groups. Cats in the control and meloxicam groups were treated daily with saline and meloxicam at 0.3 mg/kg subcutaneously for 17 days, respectively. Renal cortices and medullas were collected at the end of the treatment period. Random forest and metabolic pathway analyses were used to identify metabolites that discriminate meloxicam‐treated from saline‐treated cats and to identify disturbed metabolic pathways in renal tissue. Our results revealed that the repeated administration of meloxicam to cats altered the kidney metabolome and lipidome and suggest that at least 40 metabolic pathways were altered in the renal cortex and medulla. These metabolic pathways included lipid, amino acid, carbohydrate, nucleotide and energy metabolisms, and metabolism of cofactors and vitamins. This is the first study using a pharmacometabonomics approach for studying the molecular effects of meloxicam on feline kidneys.
U‐Pb SIMS ages of Apollo 14 zircon: Identifying distinct magmatic episodes
Authors: Thiessen F. , Nemchin A. A. , Snape J. F. , Whitehouse M. J. 
Published: June 2019

AbstractU‐Pb ages of zircon in four different Apollo 14 breccias (14305, 14306, 14314, and 14321) were obtained by secondary ion mass spectrometry. Some of the analyzed grains occur as cogenetic, poikilitic zircon grains in lithic clasts, revealing magmatic events at ~4286 Ma, ~4200–4220 Ma, and ~4150 Ma. The age distribution of the crystal clasts in the breccias exhibits a minor peak at ~4210 Ma, which can be attributed to a magmatic event, as recorded in zircon grains located in noritic clasts. An age peak at ~4335 Ma is present in all four breccias, as well as zircon grains from different Apollo landing sites, enhancing the confidence that these grains recorded a global zircon‐forming event. The overall age distribution among the four breccias exhibits minor differences between the breccias collected farther away from the Cone Crater and the ones collected within the continuous ejecta blanket of the Cone Crater. A granular zircon grain yielded a 207Pb/206Pb age of 3936 ± 8 Ma, which is interpreted as an impact event. A similar age of 3941 ± 5 Ma (n = 17, MSWD = 0.89, P = 0.58) was obtained for a large zircon grain (~430 × 340 μm in size). This grain might have crystallized in the same impact melt sheet which formed the granular zircon or the age is representative of the final extrusion of KREEP magma. The majority of zircon grains, however, occur as isolated crystal clasts within the matrix and their ages cannot be correlated with any real events (impact or magmatic) nor can the possibility be excluded that these ages represent partial resetting of the U‐Pb system.
Are there sex differences in visceral sensitivity in young healthy men and women?
Authors: Icenhour Adriane , Labrenz Franziska , Roderigo Till , Siebert Carsten , Elsenbruch Sigrid , Benson Sven 
Published: June 2019

AbstractBackgroundVisceral hypersensitivity plays a key role in the pathophysiology of chronic visceral pain like irritable bowel syndrome (IBS), which is significantly more prevalent in women. Possible sex differences in visceral sensitivity remain poorly studied. We assessed sex differences in visceral sensitivity and their association with subclinical symptoms, trait anxiety, and chronic stress in a large sample of healthy men and women.MethodsIn 280 young healthy volunteers (50% female), visceral sensory and pain thresholds were determined using rectal balloon distensions. Gastrointestinal (GI) symptoms, chronic stress, and trait anxiety as IBS‐related risk factors were assessed with questionnaires. Men and women were compared regarding visceral sensitivity and multiple regression analyses were conducted to evaluate the predictive value of sex and risk factors for visceral sensitivity. Subgroups with high, intermediate, and low sensitivity were compared regarding psychological and biological characteristics.Key ResultsMen and women did not differ in sensory or pain thresholds or in IBS‐related risk factors. In multiple regression analyses, no predictor of visceral sensitivity could be identified. While sensitivity subgroups differed in sensory and pain thresholds, the proportions of men and women were comparable, and groups did not differ in IBS‐related risk factors.Conclusions and InferencesDespite the large sample size, we found no evidence supporting sex differences in visceral sensitivity. At least in healthy young volunteers, our findings suggest that sex, GI symptoms, anxiety, or chronic stress do not contribute to altered visceral sensitivity.
Varieties of regional integration, international trade networks and risk
Authors: Seno‐Alday Sandra 
Published: June 2019

AbstractThis paper explores the relationship between regional integration models and trade network structures. The paper further investigates the implications of these trade relationship configurations on risk. The exploratory study models the European Union and the Association of Southeast Asian Nations as networks: countries in each region are nodes connected by lines representing commodity trade flows. The study compares the evolution of the two regional networks over a 25‐year period (1990–2014). The results confirm that different regional integration models lead to differently structured economic relationships. The findings show that loosely coupled networks are vulnerable to the failure of a few connected nodes (concentrated vulnerability), but that tightly coupled regional networks are vulnerable to the failure of any of its nodes (random vulnerability). These unique differences in vulnerability have critical implications for managing economic risk.