bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of chronic aortic regurgitation by 2D and 3D echocardiography and cardiac MRI
Authors: Stoebe Stephan , Metze Michael , Jurisch Daniel , Tayal Bhupendar , BoA Kilian Solty , Laufs Ulrich , Pfeiffer Dietrich , Hagendorff Andreas 
Published: March 2018

Abstract

Purpose: The study compares the feasibility of the quantitative volumetric and semi-quantitative approach for quantification of chronic aortic regurgitation (AR) using different imaging modalities.

Methods: Left ventricular (LV) volumes, regurgitant volumes (RVol) and regurgitant fractions (RF) were assessed retrospectively by 2D, 3D echocardiography and cMRI in 55 chronic AR patients. Semi-quantitative parameters were assessed by 2D echocardiography.

Results: 22 (40%) patients had mild, 25 (46%) moderate and 8 (14%) severe AR. The quantitative volumetric approach was feasible using 2D, 3D echocardiography and cMRI, whereas the feasibility of semi-quantitative parameters varied considerably. LV volume (LVEDV, LVESV, SVtot) analyses showed good correlations between the different imaging modalities, although significantly increased LV volumes were assessed by cMRI. RVol was significantly different between 2D/3D echocardiography and 2D echocardiography/cMRI but was not significantly different between 3D echocardiography/cMRI. RF was not statistically different between 2D echocardiography/cMRI and 3D echocardiography/cMRI showing poor correlations (r < 0.5) between the different imaging modalities. For AR grading by RF, moderate agreement was observed between 2D/3D echocardiography and 2D echocardiography/cMRI and good agreement was observed between 3D echocardiography/cMRI.

Conclusion: Semi-quantitative parameters are difficult to determine by 2D echocardiography in clinical routine. The quantitative volumetric RF assessment seems to be feasible and can be discussed as an alternative approach in chronic AR. However, RVol and RF did not correlate well between the different imaging modalities. The best agreement for grading of AR severity by RF was observed between 3D echocardiography and cMRI. LV volumes can be verified by different approaches and different imaging modalities.
Improved Genome Assembly and Annotation for the Rock Pigeon (Columba livia)
Authors: Holt Carson , Campbell Michael , Keays David A , Edelman Nathaniel , Kapusta Aurélie , Maclary Emily , T. Domyan Eric , Suh Alexander , Warren Wesley C , Yandell Mark , Gilbert M Thomas P , Shapiro Michael D 
Published: March 2018

Abstract
The domestic rock pigeon (Columba livia) is among the most widely distributed and phenotypically diverse avian species. C. livia is broadly studied in ecology, genetics, physiology, behavior, and evolutionary biology, and has recently emerged as a model for understanding the molecular basis of anatomical diversity, the magnetic sense, and other key aspects of avian biology. Here we report an update to the C. livia genome reference assembly and gene annotation dataset. Greatly increased scaffold lengths in the updated reference assembly, along with an updated annotation set, provide improved tools for evolutionary and functional genetic studies of the pigeon, and for comparative avian genomics in general.
El narcotráfico en la historia de las relaciones internacionales contemporáneas
Authors: CARDINALE María Eugenia 
Published: March 2018

El artículo pretende comprender la evolución del consumo y tráfico de drogas a lo largo de la historia de las relaciones internacionales contemporáneas —1789-1991—, es decir, el contexto que posibilitó su surgimiento y expansión, identificando actores, canales utilizados y principales beneficiaros. Se consideran tres subperíodos dentro del largo plazo: 1) desde el Siglo XVIII a la Tercera Guerra del Opio —1860—; 2) Desde mediados del s. XIX hasta la Segunda Guerra Mundial y 3) Desde la posguerra —1945— hasta el fin de la Guerra Fría —1991—.

Las “drogas” son tan antiguas como las civilizaciones. Sin embargo, el circuito económico productivo de las mismas irrumpe como hecho internacional en un momento específico de la historia; cuyas claves serían: la expansión colonial/imperialista occidental, el crecimiento del comercio internacional, el desarrollo de la industrialización y la consolidación de un mercado mundial. Dichas sustancias transitarán de productos tradicionales de sociedades específicas a mercancías globales de consumo masivo en el siglo XIX.
Repensar la historia diplomática: diálogos, ausencias y retos para el entendimiento de la alteridad histórica mundial
Authors: ARÉVALO ROBLES Gabriel Andrés 
Published: March 2018

El presente artículo pretende señalar las limitaciones de las teorías dominantes de las Relaciones Internacionales sobre el entendimiento histórico de la diplomacia, y la normalización hecha de las bases categoriales sobre las que es interpretada la alteridad histórica mundial, la cual invisibilizó actores, saberes y prácticas diplomáticas que perviven en la exterioridad del sistema mundial. Para respaldar las afirmaciones del texto, se aportan hechos históricos de la actividad diplomática que dan cuenta tanto de la resistencia histórica como del entendimiento político y diplomático mundial. En su conjunto, se suma a la promoción de las agendas de investigación sobre diplomacia, interesadas en comprender mejor la alteridad planetaria y su preocupación por la transformación de la violencia y la dominación global.
What’s in Metabolomics for Alcoholic Liver Disease?
Authors: Suciu Alina M , Crisan Dana A , Procopet Bogdan D , Radu Corina I , Socaciu Carmen , Tantau Marcel V , Stefanescu Horia O , Grigorescu Mircea 
Published: March 2018

Background & Aims: Current management of alcoholic liver disease (ALD), especially for alcoholic hepatitis (AH) is still driven by liver biopsy. Therefore, the identification of novel and accurate noninvasive biomarkers for the diagnosis and assessment of severity is important. Metabolomics, because it unravels changes closest to the phenotype, may represent the key for novel biomarkers. The aim of this study was to identify and characterize potential metabolomic biomarkers for diagnosis, staging and severity assessment of ALD.Methods: 30 consecutive ALD patients and 10 healthy controls were included in this proof-of-concept crosssectional study. Baseline assessment consisted in evaluation of Maddrey’s Discriminant Function, Model for End-Stage Liver Disease (MELD) and ABIC scores as well as ASH-Test (Fibromax) as a surrogate for the confirmatory diagnosis of AH in suggestive clinical and biologic settings. Additionally, SOP metabolomics and lipidomics were performed from serum samples by liquid chromatography mass-spectrometry analysis.Results: From the 127 and 135 serum/urine candidate metabolites initially identified, only 11/5 metabolites were characteristic for ALD patients. None of them correlated with alcohol intake, and only 5/1 metabolites could differentiate cirrhotic from non-cirrhotic patients. Of those, N-Lauroglycine (NLG) was the best for identifying cirrhosis (100% sensitivity and 90% negative predictive value, NPV) and decatrienoic acid (DTEA) was the best for assessing disease severity (evaluated by ABIC score) with 100% sensitivity and 100% NPV.Conclusion: Due to their high NPV, NLG and DTEA could be used in conjunction in ALD patients to exclude cirrhosis or a severe disease. If further validated, they could become biomarkers for better management and risk assessment in ALD.
Distinct Effects of two Almond Cultivars on Agreeability and Gastrointestinal Motility in Healthy Subjects: more than mere Nutraceuticals
Authors: Diella Giusy , Di Ciaula Agostino , Lorusso Michele Pio , Summo Carmine , Caggiano Giuseppina , Caponio Francesco , Montagna Maria Teresa , Portincasa Piero 
Published: March 2018

Background: Almonds are healthy nutraceuticals, which vary across different cultivars. We compared the composition, agreeability and gastrointestinal effects of two almond cultivars from different areas.Methods: Californian Carmel (CAcv) and local Apulian Filippo Cea (FCcv) cultivars were compared for the chemical composition and sensory evaluation according to visual analogue and semiquantitative scales in 60 volunteers. Gallbladder/gastric motility (ultrasonography) and orocecal transit time (H2-breath test) were studied in another 24 subjects by comparing the effects of a standard liquid test meal with isovolumetric almond test meals (24 g of CAcv or FCcv almonds).Results: Proteins prevailed in CAcv, while FCcv contained more lipids and 10-times more total phenol content than CAcv. For agreeability, CAcv scored higher than FCcv for smell, texture and appearance, although different perceptions existed in lean (scores for smell, taste, texture, appearance higher for CAcv than FCcv), obese (CAcv better than FCcv only for appearance) and elderly subjects (CAcv better than FCcv only for texture). Gallbladder emptying was stronger with FCcv than CAcv. Antral dilatation after ingestion of both cultivars was greater than the dilatation observed after the test meal. Gastric emptying, however, was similar after FCcv, CAcv and the test meal. The orocecal transit time in response to both cultivars was shorter than after the test meal.Conclusions: Differences in composition and effects of FCcv and CAcv cultivars support their potential use as valuable nutraceutical tools, to be confirmed in further clinical studies.
Cholangiocarcinoma Prognosis Varies over Time Depending on Tumor Site and Pathology
Authors: Kaneko Rena , Sato Yuzuru , Kobayashi Yasuki 
Published: March 2018

Background: Cholangiocarcinoma is a relatively rare cancer that is difficult to diagnose and has a poor prognosis. Currently, knowledge concerning its etiology, tumor localization, and pathological features remains limited. The present study aimed to clarify the clinico-epidemiologic nature of cholangiocarcinoma with its clinical subtypes using the largest regional cancer registry in Japan.Methods: Using a regional cancer registry in Kanagawa prefecture, Japan, we estimated three-year and five-year survival rates of cholangiocarcinoma patients, who were classified into two groups: intrahepatic (i-CCA) and extrahepatic cholangiocarcinoma (e-CCA) cases. The hazard ratio for each subtype, including pathological tissue type and tumor site, was calculated.Results: During the period from 1976 to 2013, 14,287 cases of cholangiocarcinoma were identified. The prognosis markedly improved after 2006, when a new type of chemotherapy for cholangiocarcinoma was introduced in Japan. Patients with i-CCA were more likely to be younger, and less likely to undergo surgery than those with e-CCA. The prognosis of cases with i-CCA was poor compared to that of patients with e-CCA.Conclusion: In Japan, i-CCA was more likely to develop in younger people and to have a poor prognosis. The prognosis of both i-CCA and e-CCA cases markedly improved after 2006. The present study describes clinico-epidemiological features of cholangiocarcinoma that may be useful for determining therapeutic strategies for this disease.
A Multi-strain Probiotic Reduces the Fatty Liver Index, Cytokines and Aminotransferase levels in NAFLD Patients: Evidence from a Randomized Clinical Trial
Authors: Kobyliak Nazarii , Abenavoli Ludovico , Mykhalchyshyn Galyna , Kononenko Liudmyla , Boccuto Luigi , Kyriienko Dmytro , Dynnyk Oleg 
Published: March 2018

Background: Probiotics have a beneficial effect on nonalcoholic fatty liver disease (NAFLD) in animal models. Randomized placebo-controlled trials (RCTs) in NAFLD are still lacking in humans despite a large number of data from animal research.Aim: We performed a double-blind single center RCT of live multi-strain probiotic vs. placebo in type 2 diabetes patients with NAFLD.Methods: A total of 58 patients met the criteria for inclusion. They were randomly assigned to receive the multiprobiotic “Symbiter” (concentrated biomass of 14 probiotic bacteria genera Bifidobacterium, Lactobacillus, Lactococcus, Propionibacterium) or placebo for 8-weeks administered as a sachet formulation in double-blind treatment. The primary main outcomes were the changes in fatty liver index (FLI) and liver stiffness (LS) measured by Shear Wave Elastography (SWE). Secondary outcomes were the changes in aminotransferase activity, serum lipids and cytokines (TNF-α, IL-1β, IL-6, IL-8, and IFN-γ) levels. Analysis of covariance was used to assess the difference between groups.Results: In the probiotic group, FLI significantly decreased from 84.33±2.23 to 78.73±2.58 (p<0.001) but it did not change in the placebo group (82.57±2.45 to 81.6 ±2.36; p=0.367). In both groups a slight but not significant reduction of LS measured by SWE was detected. Analysis of the secondary outcomes showed that probiotics reduced the level of serum AST and GGT. Among the markers of chronic systemic inflammatory state, only TNF-α and IL-6 levels changed significantly after the treatment with the probiotic.Conclusion: The probiotic “Symbiter” reduces liver fat, aminotransferase activity, and the TNF-α and IL-6 levels in NAFLD patients. Modulation of the gut microbiota might represent a new therapy for NAFLD, which should be tested in larger studies.
The Variant rs145204276 of GAS5 is Associated with the Development and Prognosis of Gastric Cancer
Authors: Li Qianjun , Ma Gang , Guo Huimin , Sun Suhua , Xu Ying , Wang Bingjian 
Published: March 2018

Background & Aims: Down-regulation of the growth arrest specific transcript 5 (GAS5) (long non-coding RNA) is associated with cell proliferation of gastric cancer (GC) and a poor prognosis. We aimed to investigate whether the variant rs145204276 of GAS5 is associated with the prognosis of GC in the Chinese population, and to unveil the regulatory mechanism underlying the GAS5 expression in GC tissues.Method: 1,253 GC patients and 1,354 healthy controls were included. The frequency of the genotype del/del and the allele del of rs145204276 were compared between the patients and the controls and between different subgroups of patients classified by clinicopathological variables. The overall survival rate was analyzed according to the Kaplan-Meier method using the log-rank test.Results: The frequency of genotype del/del was significantly lower in patients than in the controls (7.0% vs. 9.1%, p = 0.001). Kaplan-Meier analysis showed that genotype del/del was significantly associated with a higher survival rate (p = 0.01). Patients with late tumor stage were found to have a significantly lower rate of genotype del/del than those with an early tumor stage (4.9% vs. 8.8%, p = 0.01). Patients with UICC III and IV were found to have a significantly lower rate of genotype del/del than those with UICC I and II (5.3% vs. 8.1%, p = 0.02).Conclusion: The variant rs145204276 of GAS5 is associated with the development and prognosis of GC. The allele del of rs145204276 is associated with a remarkably lower incidence of cancer progression and metastasis.
Los determinantes de las exportaciones manufactureras de la economía colombiana. El papel de la Inversión Extranjera Directa en el sector. 2000-2014
Authors: Gómez Cadavid Santiago , Segura Paz Ana María 
Published: March 2018

El objetivo del artículo es capturar los determinantes que explican en el largo plazo el desempeño de las exportaciones manufactureras colombianas durante el período 2000-2014 usando un modelo de series de tiempo multivariado. Los resultados muestran que el PIB de la Comunidad Andina, PIB de Estados Unidos, tipo de cambio real, términos de intercambio, productividad laboral, índice de producción manufacturero e índice de salario real cointegran en el largo plazo con las exportaciones manufactureras. Además, el VAR demuestra que la IED dirigida al sector manufacturero impacta indirectamente a este tipo de exportaciones a través de mejoras en la productividad laboral.
Prácticas escénicas y escenarios pedagógicos alternativos: una mirada a la posibilidad de pensar el cuerpo-sujeto femenino a través de la memoria en los Montes de María
Authors: Mora Manrique Andrea Del Pilar 
Published: March 2018

En este artículo se retoma parte del entramado teórico de la investigación titulada “Cuerpos con memoria: nociones y movilizaciones del cuerpo femenino dentro de la práctica escénica en los Montes de María”. Este trabajo se realizó con siete mujeres de la vereda Villa Colombia, ubicada en Ovejas (Sucre), municipio perteneciente a la subregión de los Montes de María en la Costa Caribe colombiana. A partir de allí, se pretende ahondar en la construcción de cuerpo-sujeto como lugar de enunciación y reconstrucción de memoria, teniendo en cuenta que gran parte de los postulados de la Modernidad, como la división del cuerpo y la razón y el desconocimiento del papel activo, consiente y reflexivo del sujeto se encuentran naturalizados e interiorizados sin mayor cuestionamiento. Así mismo, la construcción del cuerpo femenino, en un contexto rural y afectado por el conflicto armado colombiano, se ha encargado de elaborar una serie de cuerpos-sujetos determinados.Pensar las prácticas escénicas como posibles lugares pedagógicos que invitan a preguntarse y reflexionar por la construcción del cuerpo-sujeto, por sus memorias y, sobre todo, por la construcción de futuro, son algunos de los argumentos que se desglosarán a continuación. Palabras clave: cuerpo-sujeto, cuerpo femenino, corporeidad, memoria, prácticas escénicas.
WITTGENSTEIN Y BOURDIEU A PROPÓSITO DEL TRABAJO DE CAMPO Y LA INVESTIGACIÓN
Authors: Arenas Monsalve Eliécer 
Published: March 2018

Este trabajo apunta a asimilar el aporte crítico de algunas corrientes filosóficas que han asumido como central el problema de la investigación de las prácticas humanas. Tomando aspectos de la obra de Ludwing Wittgenstein y de Pierre Bourdieu, el texto llama la atención sobre la necesidad de contar con un marco conceptual esclarecedor, capaz de dar luces sobre cómo pensar una indagación que esté a la altura de las dificultades reales de nuestro trabajo como investigadores. Este trabajo surge de la necesidad de ir construyendo un dispositivo conceptual más personal, riguroso, complejo y sugerente para poder sacar mejor provecho y lograr dinamizar el ineludible y central ";trabajo de campo"; que implica la investigación de las prácticas artísticas, culturales y pedagógicas de nuestro medio.
El secreto.
Authors: Torres Beltrán Victor Ricardo 
Published: March 2018

En el proceso evolutivo, la experiencia ha demostrado que lo que en un momento inicial se acepta como verdad única, con el transcurrir del tiempo y después de repetirlo muchas veces, empieza a vislumbrarse con otras posibilidades que en el principio fueron consideradas erróneas. En su proceso evolutivo, la guitarra no ha alcanzado aún su madurez, en cuanto a su plenitud sonora, tal como la tienen el violín o el piano, entre otros instrumentos. Aquella posee un universo sonoro particular, el cual -con algunas excepciones- no se ha explotado en su totalidad, pues muchos compositores e intérpretes evitan los así llamados ";sonidos parásitos";, a los que los consideran desagradables, inútiles, o no musicales. Esto es relativo, dependiendo de cómo estén integrados en la obra y de cuál sea su intención expresiva, pues presentan una riqueza de posibilidades tímbricas, creando nuevos espacios de expresión -tanto en el ámbito tonal como en el atonal- son evocadores, e invitan a la creación.
REPARAÇÃO EM RESINA COMPOSTA: REVISÃO SISTEMÁTICA
Authors: De Alencar Vilson Rocha Cortez Teles , Cavalcante Micael , Firmino Rodrigo , Santos Jackceane , De Lima João Paulo Martins 
Published: March 2018

Introdução: A substituição total de restaurações de resina composta é uma das técnicas mais utilizadas por cirurgiões dentistas quando estas restaurações apresentam alguma falha. Essa técnica amplia o preparo cavitário, removendo tecido dentário sadio, podendo gerar danos pulpares. A reparação de resina composta substitui parcialmente a restauração preservando estrutura dental e o substrato remanescente de resina composta. Objetivo: Realizar uma revisão sistemática por meio de estudos que descrevessem a eficácia clínica e laboratorial da reparação em restaurações de resina composta defeituosas. Método: Como base para a pesquisa, foram acessados os bancos de dados PubMed, Scopus, BVS e SciELO, os descritores selecionados através do DesC e MeSH foram, Resinas compostas, Desgaste de restauração dentária, Falha de restauração dentária, Reparação de restauração dentária. Resultados: Foram incluídos todos os artigos que abordassem sobre a técnica de reparação. Conclusão: Existem poucas evidências cientificas que mostrem o sucesso e vantagens desse método sobre a substituição total, porém os estudos analisados já apresentam bons resultados.
CORRELAÇÃO ENTRE FACETAS DE DESGASTE E A OCORRÊNCIA DE LESÕES CERVICAIS NÃO CARIOSAS: UMA REVISÃO DE LITERATURA
Authors: Lemos Junior Francisco Amaro , Alves Narezze Gomes , Figueiredo Viviane 
Published: March 2018

A elevada prevalência de facetas de desgaste na população jovem é um alerta para que estas alterações sejam observadas e ferramentas sejam criadas para agilizar o processo de diagnóstico. Objetivou-se revisar a literatura sobre a influência das facetas de desgaste no surgimento de lesões cervicais não cariosas. Pesquisou-se sobre facetas de desgaste e lesões cervicais não cariosas, nas bases de dados Bireme, Lilacs, Pubmed e Bibliotecas Virtuais, em estudos in vitro, in silico (elementos finitos), ensaios clínicos e revisões sistemáticas com metanálise. Incluindo artigos em português, inglês e espanhol, sendo excluídos os de revisão de literatura, caso clínico, carta ao editor, e os estudos que não abordarem as variáveis em questão. A literatura apresenta-se escassa, assim são necessários novos estudos longitudinais para melhor entendimento dessa associação, bem como, para definir os parâmetros universais para a avaliação de desgaste dental e estabelecimento do seu diagnóstico, com a finalidade de obter a melhor forma de tratamento desses problemas cada vez mais frequentes na clínica diária.
Competencia judicial internacional en supuestos de responsabilidad extracontractual en internet: nuevos criterios interpretativos en la determinación del lugar de producción del daño. A propósito de la STJUE Concurrence vs. Samsung y Amazon, de 21 de diciembre de 2016 = International jurisdiction in matter of noncontractual liabillity on the internet: new criteria in determining the place where the harmful event ocurred. Analyzing the STJUE Concurrence vs. Samsung y Amazon, of 21 de december 2016
Authors: Villamarín López María Luisa 
Published: March 2018

Resumen: En el presente artículo se analiza el nuevo criterio jurisprudencial sentado en diciembre de 2016 por el TJUE en materia de responsabilidad extracontractual en Internet a propósito de una infracción de un contrato de distribución en exclusiva. La especial naturaleza de las relaciones jurídicas en juego sirvió en este caso para descartar los criterios de conexión empleados hasta entonces como el de accesibilidad o el de las actividades dirigidas y para fijar como foro especial el del sitio donde se sufrió efectivamente la reducción de las ventas, garantizándose el cumplimiento de los fines que persiguen estas normas así como la reducción del riesgo de forum shopping.Palabras clave: Reglamento 44/2001 (y 1215/2012), responsabilidad civil extracontractual, lugar de producción del daño, contrato de distribución exclusiva. Abstract: This article analyzes the new jurisprudential criterion established in December 2016 by the CJEU in the field of torts on the Internet in connection with an infringement of an exclusive distribution contract. The special nature of the legal relationships at stake served in this case to reject the connection criteria used until then as the accessibility and to set as a special forum the place where the reduction in sales was effectively suffered, thus guaranteeing the fulfillment of the purposes pursued by these european rules as well as reducing the risk of forum shopping.Keywords: Regulation 44/2001 (and 1215/2012), non-contractual liability, place where the harmful event occurred, exclusive distribution contract.