bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunometabolic function of cholesterol in cardiovascular disease and beyond
Authors: Yvan-Charvet Laurent , Bonacina Fabrizia , Guinamard Rodolphe Renè , Norata Giuseppe Danilo 
Published: May 2019

AbstractInflammation represents the driving feature of many diseases, including atherosclerosis, cancer, autoimmunity and infections. It is now established that metabolic processes shape a proper immune response and within this context the alteration in cellular cholesterol homeostasis has emerged as a culprit of many metabolic abnormalities observed in chronic inflammatory diseases. Cholesterol accumulation supports the inflammatory response of myeloid cells (i.e. augmentation of toll-like receptor signalling, inflammasome activation, and production of monocytes and neutrophils) which is beneficial in the response to infections, but worsens diseases associated with chronic metabolic inflammation including atherosclerosis. In addition to the innate immune system, cells of adaptive immunity, upon activation, have also been shown to undergo a reprogramming of cellular cholesterol metabolism, which results in the amplification of inflammatory responses. Aim of this review is to discuss (i) the molecular mechanisms linking cellular cholesterol metabolism to specific immune functions; (ii) how cellular cholesterol accumulation sustains chronic inflammatory diseases such as atherosclerosis; (iii) the immunometabolic profile of patients with defects of genes affecting cholesterol metabolism including familial hypercholesterolaemia, cholesteryl ester storage disease, Niemann–Pick type C, and immunoglobulin D syndrome/mevalonate kinase deficiency. Available data indicate that cholesterol immunometabolism plays a key role in directing immune cells function and set the stage for investigating the repurposing of existing ‘metabolic’ drugs to modulate the immune response.
Separating different individual effects in a panel data model
Authors: Amsler Christine , Schmidt Peter 
Published: May 2019

SummaryIn this paper we consider a panel data model with individual effects that are arbitrarily correlated with the explanatory variables. The effects are composed as the sum of two different interpretable components, such as inefficiency versus heterogeneity in a production frontier setting, or ability versus socioeconomic background in an earnings function, or genetics versus environment in an epidemiological analysis. We wish to predict the two components separately. This is made possible by assuming that there are observables that are correlated with the first component but not with the second, and other observables that are correlated with the second component but not with the first. This can be true in terms of either simple correlations or partial correlations.
Species co-occurrence and environmental factors and their effect on the distribution of forest birds in mature forests
Authors: Andradas Mikel Xabier , Arizaga Juan , Rodríguez-Pérez Javier 
Published: May 2019

Abstract
Measures of species co-occurrence, as a proxy of biotic interactions, may be as important as environmental factors when explaining the distribution of many species. We assessed the relative effect of both species co-occurrence and environmental factors in predicting the occurrence (presence/absence) of woodpeckers and passerines in mature forests of the Northern Iberian Peninsula. We hypothesized that woodpecker occurrence would affect the occurrence of passerines. We calculated the occurrence of woodpecker species using models that included environmental factors aggregated at three spatial scales (200, 500 and 1,000-m2). The occurrence of passerine species was then modelled by using either species co-occurrence (including the occurrence of woodpecker species) or environmental factors at the 200-m2 cell scale. The occurrence of five out of nine passerine species was best explained by the co-occurrence of woodpeckers alone, whereas the occurrence of the remaining passerines was best explained using a combination of species co-occurrence (i.e. woodpeckers and/or other passerines) and environmental factors. In Southern Europe, woodpeckers are expanding their distribution in line with forest maturation, and this could increase the diversity of bird communities in forest systems.
Persistent Salmonella enterica Serovar Typhimurium Infection Induces Protease Expression During Intestinal Fibrosis
Authors: Ehrhardt Katrin , Steck Natalie , Kappelhoff Reinhild , Stein Stephanie , Rieder Florian , Gordon Ilyssa O , Boyle Erin C , Braubach Peter , Overall Christopher M , Finlay B Brett , Grassl Guntram A 
Published: May 2019

AbstractBackgroundIntestinal fibrosis is a common and serious complication of Crohn’s disease characterized by the accumulation of fibroblasts, deposition of extracellular matrix, and formation of scar tissue. Although many factors including cytokines and proteases contribute to the development of intestinal fibrosis, the initiating mechanisms and the complex interplay between these factors remain unclear.MethodsChronic infection of mice with Salmonella enterica serovar Typhimurium was used to induce intestinal fibrosis. A murine protease-specific CLIP-CHIP microarray analysis was employed to assess regulation of proteases and protease inhibitors. To confirm up- or downregulation during fibrosis, we performed quantitative real-time polymerase chain reaction (PCR) and immunohistochemical stainings in mouse tissue and tissue from patients with inflammatory bowel disease. In vitro infections were used to demonstrate a direct effect of bacterial infection in the regulation of proteases.ResultsMice develop severe and persistent intestinal fibrosis upon chronic infection with Salmonella enterica serovar Typhimurium, mimicking the pathology of human disease. Microarray analyses revealed 56 up- and 40 downregulated proteases and protease inhibitors in fibrotic cecal tissue. Various matrix metalloproteases, serine proteases, cysteine proteases, and protease inhibitors were regulated in the fibrotic tissue, 22 of which were confirmed by quantitative real-time PCR. Proteases demonstrated site-specific staining patterns in intestinal fibrotic tissue from mice and in tissue from human inflammatory bowel disease patients. Finally, we show in vitro that Salmonella infection directly induces protease expression in macrophages and epithelial cells but not in fibroblasts.ConclusionsIn summary, we show that chronic Salmonella infection regulates proteases and protease inhibitors during tissue fibrosis in vivo and in vitro, and therefore this model is well suited to investigating the role of proteases in intestinal fibrosis.
Endocrine Disruption Alters Developmental Energy Allocation and Performance in Rana temporaria
Authors: Ruthsatz Katharina , Dausmann Kathrin H , Reinhardt Steffen , Robinson Tom , Sabatino Nikita M , Peck Myron A , Glos Julian 
Published: May 2019

AbstractEnvironmental change exposes wildlife to a wide array of environmental stressors that arise from both anthropogenic and natural sources. Many environmental stressors with the ability to alter endocrine function are known as endocrine disruptors, which may impair the hypothalamus–pituitary–thyroid axis resulting in physiological consequences to wildlife. In this study, we investigated how the alteration of thyroid hormone (TH) levels due to exposure to the environmentally relevant endocrine disruptor sodium perchlorate (SP; inhibitory) and exogenous L-thyroxin (T4; stimulatory) affects metabolic costs and energy allocation during and after metamorphosis in a common amphibian (Rana temporaria). We further tested for possible carry-over effects of endocrine disruption during larval stage on juvenile performance. Energy allocated to development was negatively related to metabolic rate and thus, tadpoles exposed to T4 could allocate 24% less energy to development during metamorphic climax than control animals. Therefore, the energy available for metamorphosis was reduced in tadpoles with increased TH level by exposure to T4. We suggest that differences in metabolic rate caused by altered TH levels during metamorphic climax and energy allocation to maintenance costs might have contributed to a reduced energetic efficiency in tadpoles with high TH levels. Differences in size and energetics persisted beyond the metamorphic boundary and impacted on juvenile performance. Performance differences are mainly related to strong size-effects, as altered TH levels by exposure to T4 and SP significantly affected growth and developmental rate. Nevertheless, we assume that juvenile performance is influenced by a size-independent effect of achieved TH. Energetic efficiency varied between treatments due to differences in size allocation of internal macronutrient stores. Altered TH levels as caused by several environmental stressors lead to persisting effects on metamorphic traits and energetics and, thus, caused carry-over effects on performance of froglets. We demonstrate the mechanisms through which alterations in abiotic and biotic environmental factors can alter phenotypes at metamorphosis and reduce lifetime fitness in these and likely other amphibians.
Rights and Relationships: Rhetorics of Religious Freedom among English Evangelicals
Authors: McIvor Méadhbh 
Published: May 2019

AbstractThis paper uses evangelical reflections on the meaning of “rights” to explore the juridification of religion in contemporary England. Drawing on sixteen months of participatory fieldwork with evangelicals in London, I argue that English evangelicals’ critiques of Christian-interest litigation reflect the interaction of local theologies with developments in the law’s regulation of religion, developments that have contributed to the relativization of Protestant Christianity even as historic church establishment is maintained. Through an exploration of the tension between the goals of (rights-based) individualism and (Christian) relationalism as they concern the law, I show how litigation can affect religious subjectivity even in the absence of a personal experience with the pageantry of the court.
Penalizing cartels—a spectrum of regimes
Authors: Katsoulacos Yannis , Motchenkova Evgenia , Ulph David 
Published: May 2019

Abstract
There has been much discussion by both academics and policymakers of the most appropriate way of penalizing cartels taking account of both the effects of different penalty regimes on welfare as well as various implementation considerations such as ease/cost of implementation and transparency/legal certainty. Consequently there now exists a range of proposed penalty regimes—including two put forward by ourselves. While these can all seem like very distinct regimes, in this article we show that they can usefully be thought of as lying along a spectrum, inter-connected by the idea of trying to penalize cartels in relation to the damage they cause. They differ in their informational requirements, and in particular whether some key factors needed to calculate the penalty are case-specific or an average across a wide range of cases. Subtle differences in what information is required and how it is used can sometimes cause significant changes in either the welfare or implementation properties of regimes. This new perspective may provide a helpful way of organizing the discussion about the pros and cons of the different proposals.
The Relationship of Level of Education to Social Reintegration after Burn Injury: A LIBRE Study
Authors: Schulz John T , Shapiro Gabriel D , Acton Amy , Fidler Philip , Marino Molly E , Jette Allen , Schneider Jeffrey E , Kazis Lewis E , Ryan Colleen M 
Published: May 2019

Abstract
Social and emotional recovery from burn injury is a complex process impacted by both clinical and social factors. Because level of education (LOE) has been correlated to overall health, health outcomes, and life expectancy, we questioned whether LOE might be associated with successful social recovery after burn injury. The Life Impact Burn Recovery Evaluation (LIBRE) data set served as a novel tool to explore this question. The LIBRE project is a collaborative effort designed to provide a clinical yardstick for social reintegration among burn survivors. After institutional review board approval, 601 burn survivor respondents, aged 18 or over with >5% TBSA burn were surveyed and a six-scale, 126-item LIBRE Profile was derived from their responses. LOE was collapsed into four categories ranging from less than high school equivalency certificate to graduate degree. Impact of burn injury on subsequent LOE was examined by splitting the sample into those burned at age 30 years or less and those burned at greater than 30 years of age. Regression models were run to estimate associations between education and scale scores with adjustment for age at injury, sex, marital status, work status, TBSA, and time since burn. Regression models were run on the entire cohort and then stratified by age at burn injury (≤30 vs >30). Among all subjects, we found an association between LOE and social recovery as measured by LIBRE scale scores. This association was contributed entirely from the cohort burned at age 30 or less: for those burned at greater than age 30, there was no association between LOE and social recovery. Of particular interest, the distribution of LOE among those burned at ≤ 30 was very similar to LOE distribution in both millennials and in the U.S. population at large. LOE appears to be associated with social recovery for those burned at younger ages but not for those burned at over age 30. More importantly, burn injury during schooling may have no impact on a survivor’s educational trajectory since distribution of LOE in our ≤30 cohort mirrors that of the general population. LOE and age at burn injury may provide a quick screen for survivors at risk of difficult social reintegration, allowing providers to target those at risk with additional peer support and counseling.
Up All Night Out of Love for the Prophet: Devotion, Sanctity, and Ritual Innovation in the Ottoman Arab Lands, 1500–1620
Authors: Allen Jonathan Parkes 
Published: May 2019

Abstract
Devotion to the Prophet Muḥammad was a major feature of late medieval and early modern Islamic religious life across much of the Islamic world. The history of this devotion remains understudied in relation to its importance and pervasiveness. This study takes as its locus of analysis a particular instance of early modern devotion: a weekly, public all-night session of ṣalawāt upon the Prophet that would become known as the maḥyā. Developed by the peasant-turned-shaykh Nūr al-Dīn al-Shūnī in late Mamluk Egypt, performance of the maḥyā would spread over the following century throughout the Arab Ottoman world, undergoing changes, provoking controversy, and becoming embedded in the sacred spaces and ritual life of one city after another. I approach the history of the maḥyā as a discrete and legible instance of ritual change in an Islamic context, exploring this instance of communal devotion to the Prophet through such lenses as ritual studies and the spatial turn, examining the intersection of this devotional ritual with practices of subjectivity, the use and contestation of ritual space, and the meaning, regulation, and experience of the night.
Is Genetic Continuity Between Anopheles sinensis (Diptera: Culicidae) and its Sibling Species Due to Gene Introgression or Incomplete Speciation?
Authors: Wang Gang , Guo Xiaoxia , Song Fenglin , Zheng Wei , Tan Weilong , Huang Enjiong , Wu Jiahong , Wang Chongcai , Yang Qinggui , Li Chunxiao , Zhao Tongyan 
Published: May 2019

AbstractThe Anopheles mosquito Hyrcanus Group is widely distributed geographically across both Palearctic and Oriental regions and comprises 26 valid species. Although the species Anopheles sinensis Wiedemann (1828) is the most common in China and has a low potential vector rank, it has nevertheless long been thought to be an important natural malaria vector within the middle and lower reaches of the Yangtze River. A number of previous research studies have found evidence to support the occurrence of natural hybridization between An. sinensis and Anopheles kleini Rueda, 2005 (a competent malaria vector). We, therefore, collected a sample series of An. sinensis and morphologically similar species across China and undertook ribosomal and mitochondrial DNA analyses in order to assess genetic differentiation (Fst) and gene flow (Nm) amongst different groups. This enabled us to evaluate divergence times between morphologically similar species using the cytochrome oxidase I (COI) gene. The results of this study reveal significant genetic similarities between An. sinensis, An. kleini, and Anopheles belenrae Rueda, 2005 and therefore imply that correct molecular identifications will require additional molecular markers. As results also reveal the presence of gene flow between these three species, their taxonomic status will require further work. Data suggest that An. kleini is the most basal of the three species, while An. sinensis and An. belenrae share the closest genetic relationship.
Effect of a Responsiveness-Based Support Intervention on Smokeless Tobacco Cessation: The UCare-ChewFree Randomized Clinical Trial
Authors: Akers Laura , Andrews Judy A , Lichtenstein Edward , Severson Herbert H , Gordon Judith S 
Published: May 2019

Abstract

Introduction
Partner behaviors and attitudes can motivate or undermine a tobacco user’s cessation efforts. We developed a multimedia intervention, UCare (Understanding-CAring-REspect) for women who wanted their male partner to quit smokeless tobacco (ST), based on perceived partner responsiveness—the empirically based theory that support is best received when the supporter conveys respect, understanding, and caring.

Methods
One thousand one hundred three women were randomized to receive either immediate access to the UCare website and printed booklet (Intervention; N = 552), or a Delayed Treatment control (N = 551). We assessed supportive behaviors and attitudes at baseline and 6-week follow-up, and the ST-using partner’s abstinence at 6 weeks and 7.5 months (surrogate report).

Results
For partners of women assigned to Intervention, 7.0% had quit all tobacco at 7.5 months, compared with 6.6% for control (χ2 (1, n = 1088) = .058, p = .810). For partners of women completing the intervention, 12.4% had quit all tobacco at 7.5 months, compared with 6.6% for Delayed Treatment (χ2 (1, n = 753) = 6.775, p = .009). A previously reported change in responsiveness-based behaviors and instrumental behaviors at 6 weeks mediated 7.5-month cessation, and change in responsiveness-based attitudes mediated the change in responsiveness-based behaviors, indirectly increasing cessation.

Conclusions
A responsiveness-based intervention with female partners of male ST users improved supportive attitudes and behaviors, leading to higher cessation rates among tobacco users not actively seeking to quit. The study demonstrates the potential for responsiveness as a basis for effective intervention with supporters. This approach may reach tobacco users who would not directly seek help.

Implications
This study demonstrates the value of a responsiveness-based intervention (showing respect, understanding, and caring) in training partners to provide support for a loved one to quit ST. In a randomized clinical trial, 1,103 women married to or living with a ST user were randomized to receive the UCare-ChewFree intervention (website + booklet) or a Delayed Treatment control. Women completing the intervention were more likely to improve their behaviors and attitudes, and change in behaviors and attitudes mediated cessation outcomes for their partners, who had not enrolled in the study and may not have been seeking to quit.

Trial Registration
ClinicalTrials.gov NCT01885221
Risk Factors for Failure of Primary (Val)ganciclovir Prophylaxis Against Cytomegalovirus Infection and Disease in Solid Organ Transplant Recipients
Authors: Khurana Mark P , Lodding Isabelle P , Mocroft Amanda , Sørensen Søren S , Perch Michael , Rasmussen Allan , Gustafsson Finn , Lundgren Jens D 
Published: May 2019

Abstract

Background
Rates and risk factors for cytomegalovirus (CMV) prophylaxis breakthrough and discontinuation were investigated, given uncertainty regarding optimal dosing for CMV primary (val)ganciclovir prophylaxis after solid organ transplantation (SOT).

Methods
Recipients transplanted from 2012 to 2016 and initiated on primary prophylaxis were followed until 90 days post-transplantation. A (val)ganciclovir prophylaxis score for each patient per day was calculated during the follow-up time (FUT; score of 100 corresponding to manufacturers’ recommended dose for a given estimated glomerular filtration rate [eGFR]). Cox models were used to estimate hazard ratios (HRs), adjusted for relevant risk factors.

Results
Of 585 SOTs (311 kidney, 117 liver, 106 lung, 51 heart) included, 38/585 (6.5%) experienced prophylaxis breakthrough and 35/585 (6.0%) discontinued prophylaxis for other reasons. CMV IgG donor+/receipient- mismatch (adjusted HR [aHR], 5.37; 95% confidence interval [CI], 2.63 to 10.98; P &lt; 0.001) and increasing % FUT with a prophylaxis score &lt;90 (aHR, 1.16; 95% CI, 1.04 to 1.29; P = .01 per 10% longer FUT w/ score &lt;90) were associated with an increased risk of breakthrough. Lung recipients were at a significantly increased risk of premature prophylaxis discontinuation (aHR, 20.2 vs kidney; 95% CI, 3.34 to 121.9; P = .001), mainly due to liver or myelotoxicity.

Conclusions
Recipients of eGFR-adjusted prophylaxis doses below those recommended by manufacturers were at an increased risk of prophylaxis breakthrough, emphasizing the importance of accurate dose adjustment according to the latest eGFR and the need for novel, less toxic agents.
Giant Choroid Plexus Papilloma Resection Utilizing a Transcollation System
Authors: Asmaro Karam , Pawloski Jacob , Skoch Jesse 
Published: May 2019

Abstract

BACKGROUND
Large vascular brain tumors pose an exceptional challenge in young children. Choroid plexus papilloma (CPP) is an example of a rare, often large and especially vascular neuroepithelial tumor that most commonly arises in children under 5 yr old. Although patients may be cured by total resection, this tumor poses significant surgical risks and challenges related to intraoperative hemostasis.

OBJECTIVE
To describe our experience using a transcollation system during brain tumor surgery in a child to achieve hemostasis and minimize blood loss while preserving normal brain tissue.

METHODS
A 3-yr-old girl presented following a fall and was found to have a giant CPP growing from the right lateral ventricle. Given the vascularity of the tumor and the low intravascular reserve in a small child, a transcollation device was used to reduce blood loss intraoperatively.

RESULTS
Gross total resection was achieved with approximately 300 mL of blood loss without complications. The patient did well postoperatively. Imaging performed at 3 mo after resection revealed return of normal brain architecture.

CONCLUSION
Transcollation devices appear to be an effective and safe addition to the armamentarium of neurosurgical hemostatic options in intracranial tumor resection in which there is a high risk of intraoperative hemorrhage.