bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study protocol for a randomized controlled trial to adapt a posttraumatic stress disorder intervention of patients with opioid-stimulant polysubstance use receiving methadone maintenance treatment
Authors: Renn Tanya , Griffin Brittany , Kumaravelu Vinodini , Ventuneac Ana , Santacatterina Michele , Bunting Amanda M. 
Published: December 2024

Abstract
Background
The purpose of the Treatment for Harnessing Resiliency, Improving emotional regulation, and empowering indiViduals for a brighter future (THRIVE) study is to adapt an evidence-based posttraumatic stress disorder (PTSD) treatment for use among a polysubstance population receiving methadone maintenance treatment (MMT) at an opioid treatment program. Polysubstance use of high-risk combinations, such as illicit opioids and stimulants, is a critical public health issue. Individuals who engage in these high-risk combinations are more likely to have histories of childhood trauma, multiple traumas, PTSD, and greater PTSD severity as compared to mono-substance using individuals. Trauma, co-morbid mental health disorders such as PTSD, and polysubstance use complicate treatment outcomes. This study will use eight study phases to adapt an existing evidence-based PTSD intervention, Skills Training in Affective and Interpersonal Regulation with Narrative Therapy (STAIR-NT), via a massed treatment model (i.e., condensed treatment schedule) for patients in MMT who are engaged in sustained opioid-stimulant polysubstance use.

Methods and analysis
The intervention is an adapted version of the STAIR-NT protocol. The massed version created includes four 60-min sessions of skill building and two weeks of four 60-min sessions of narrative therapy. A preliminary randomized controlled trial (RCT) with 80 participants, randomized 1:1, will be conducted to assess the intervention's implementation and impact on primary short-term outcomes of polysubstance use and PTSD symptoms.

Ethics and dissemination
The results of this study will inform a fully-powered effectiveness trial for individuals with PTSD and polysubstance use receiving MMT. The findings are expected to provide valuable insights into improving both PTSD and substance use outcomes, and real-world implementation insights to integrating trauma-informed care in treatment settings for vulnerable populations.

Registration
This study is registered at ClinicalTrials.Gov as NCT06307340. Registration date 03/2024.
Challenged by patients: a qualitative study of clinical supervisions of endocrinologists conducted by psychiatric liaison clinicians
Authors: Mazouni Nedjma , Stiefel Friedrich , Bourquin Céline , Ludwig Gundula , Michaud Laurent 
Published: December 2024

Abstract
Background
Clinical supervision by psychiatric liaison clinicians is frequently provided in medical settings such as oncology and palliative care, but rarely in endocrinology. Consequently, the specific psychosocial issues faced by endocrinologists in their daily clinical practice and how they deal with them remain largely unknown. We aimed to explore individual supervisions of endocrinologists to gain insight into what kind of clinical situations they present, how they react to them and how this is worked through in supervision.

Methods
The data set consisted of eight audio-recorded first supervision sessions of endocrinologists conducted by liaison psychiatry clinicians, which were transformed into written core stories accounting for key components of each session. A secondary analysis of these core stories was conducted using an interpretative approach, focusing on (i) the types of clinical situations and (ii) the supervisees’ counter-attitudes towards patients. Additionally, particular attention was given to how the supervisors worked through these elements.

Results
Endocrinologists presented patients who did not adhere to treatment, behaved inexplicably, or held moral values that differed from their own. Challenged by these situations, supervisees experienced negative emotions (e.g., anxiety, irritation, guilt), associated with behavioral reactions (e.g., avoidance) and/or defensive stances (e.g., denial, rationalization). In half of the supervisions, addressing these difficulties allowed supervisees to link key characteristics of the patient interaction with their own unresolved issues; in the other half, supervisees were less inclined to confront themselves with their own contributions to the patient interaction and the supervisor adopted a more active stance, making specific contributions (e.g. support, advise).

Conclusions
The findings call for training programs addressing “difficult” patients and advocate for closer collaboration between endocrinologists and liaison psychiatry clinicians.
Paratuberculosis in South American camelids: two independent cases in alpacas in Germany
Authors: Köhler Heike , Müller Jana , Kloß Elena , Möbius Petra , Barth Stefanie A. , Sickinger Marlene , Gies Nicole , Heydel Carsten , Peters Martin 
Published: December 2024

Abstract
Background
Paratuberculosis, caused by Mycobacterium avium subspecies paratuberculosis (MAP), is a chronic granulomatous enteritis that affects domestic and wild ruminants and camelids. The disease has rarely been reported in alpacas in Germany. This publication describes epidemiologically independent cases of paratuberculosis in two alpacas in Germany.

Case presentation
Two alpacas, a 26-year-old female zoo animal (case 1) and a 2.5-year-old breeding stallion from a private owner (case 2), presented with progressive emaciation, leading to death (case 2) or euthanasia (case 1) because of deteriorating general condition. In both cases typical granulomatous lesions in the intestinal mucosa and mesenteric lymph nodes were found. In case 2, other lymph nodes were severely enlarged and MAP was detected in the mandibular lymph node, lung, and liver by qPCR. The MAP isolates differed between the alpacas, with two distinct phylogenetic clades (Clade 1 and 8) within Subgroup A of the MAP-C type group and two distinct INMV profiles (INMV 2 and 1) found. These genotypes have been identified in cattle and goats in different regions in Germany. The genotype isolated from case 1 has been detected in goats from the zoo since 2011, indicating transmission between these species.

Conclusions
MAP can cause severe clinical disease in alpacas of variable age and under different husbandry conditions. Therefore, paratuberculosis should be considered for differential diagnosis in alpacas with emaciation and poor general condition. Although not definitely shown, cross-species infection between ruminant species and camelids is exceedingly likely.
Lung function in adult patients with osteogenesis imperfecta: a cohort study
Authors: Lenoir Alexandra , Aubry-Rozier Bérengère , Bregou Aline , Gonzalez Rodriguez Elena , Paquier Célia , Tanniger Joëlle , Faouzi Mohamed , Lazor Romain 
Published: December 2024

Abstract
Background
Osteogenesis imperfecta (OI) is a rare hereditary bone disease resulting from a defect in collagen synthesis or processing, leading to bone fragility, frequent fractures and skeletal deformities. OI is associated with increased respiratory morbidity and mortality, but the mechanisms of lung involvement are poorly understood, and there are no data on the natural history of lung function. We studied lung function over time in a cohort of adult OI patients at one center.

Methods
We used data from OI patients aged 15 and above followed up at the Lausanne university hospital between 2012 and 2023 with available pre-bronchodilator spirometry. Associations between spirometric measurements at first visit and clinical characteristics were studied through linear regression. Changes of spirometric variables over time were analysed through mixed linear regression. Models were adjusted for age, sex, height and OI type (Sillence classification).

Results
Among 46 subjects, 24% had impaired spirometry at baseline, with similar distribution between restrictive (8.7%), obstructive (8.7%) and mixed (6.5%) ventilatory patterns. At first visit, higher age was associated with lower FEV1 (β = −0.019 l, p = 0.014) and lower FEV1/FVC (β = −0.175%, p = 0.012). A history of asthma was associated with higher FEV1 (β = 0.636 l, p = 0.028) and FVC (β = 0.834 l, p = 0.010). At first visit, FEV1 (β = −0.750 l, p = 0.006) and FVC (β = −0.859 l, p = 0.004) was lower in individuals with OI Sillence types 3, 4 or 5 compared to type 1. Over a mean follow-up of 3.4 years, smokers had a greater decline of FEV1/FVC compared to non-smokers (β = −6.592%, p = 0.007). Individuals with a mutation in the gene COL1A2 had 740 ml lower FVC compared to those with a mutation in COL1A1 (p = 0.037). After adjustment for sex, age, height and OI type, FEV1 increased by 26 ml (95% CI 8; 45) or 1.28%pred (0.51; 2.05) and FVC increased by 25 ml (95% CI 8; 43) or 0.93%pred (0.31; 1.55) per year of follow-up.

Conclusions
An increase of FEV1 and FVC over time was observed in OI patients after adjustment for other variables, suggesting that the defective collagen synthesis may impact the pulmonary interstitium and lead to increased lung compliance and hyperinflation, in contrast to skeletal deformities, which reduce the thoracic volume. Lung function changes in OI thus result from the interplay of several mechanisms.
First detection of Culex tritaeniorhynchus in Western Australia using molecular diagnostics and morphological identification
Authors: Evasco Kimberly L. , Brockway Craig , Falkingham Tamara , Hall Margaret , Wilson Nerida G. , Potter Abbey 
Published: December 2024

Abstract

Background

Culex tritaeniorhynchus has long been considered the primary vector of Japanese encephalitis virus (JEV), but until recently, it was considered exotic to Australia. When the species was detected in the country’s Northern Territory (NT) for the first time, the Western Australia (WA) Department of Health was cognisant of the risk it posed to the State because of the shared border and continuous mosquito habitat adjoining the two jurisdictions. The aim of this study was to undertake intensive mosquito surveillance in the Kimberley region to ascertain whether Cx. tritaeniorhynchus was present in WA, define the extent of its distribution and undertake phylogenetic analysis of select specimens to support hypothesized routes of entry into the state.

Methods
Carbon dioxide (CO2)-baited encephalitis virus surveillance (EVS) mosquito traps were deployed at various sites throughout the Kimberley region by surveillance officers within the Medical Entomology unit of the Western Australia (WA) Department of Health. Mosquitoes were then morphologically identified, and a subset of four specimens were confirmed as Cx. tritaeniorhynchus by molecular identification using Cytochrome Oxidase I (COI) DNA data and phylogenetic analysis.

Results
From 31 March 2021 to 30 May 2024, a total of 211 female Cx. tritaeniorhynchus specimens were collected from 21 unique trap sites in the Kimberley’s Shire of Wyndham-East Kimberley (SWEK). Four COI DNA barcode regions were amplified and successfully sequenced for analysis. These sequences fell within a clade recognised as Cx. tritaeniorhynchus and specifically all sequences were in a clade with other specimens from the NT and Timor-Leste.

Conclusions
This study represents the first detection of Cx. tritaeniorhynchus in WA. Given the widespread nature of trap sites that yielded the species and consecutive seasons over which it was observed, the authors surmise that Cx. tritaeniorhynchus is now established within the northeast Kimberley region. The findings are significant given the detection of the species coincides with the first significant outbreak of JEV activity on mainland Australia involving an estimated 45 human cases of Japanese encephalitis, 80 impacted commercial piggeries and widespread feral pig activity. Although the role that Cx. tritaeniorhynchus may play in JEV transmission into the future is not yet understood, it presents a potential risk to public health in the region.

Graphical abstract
The relative risk of clinically relevant cholelithiasis among glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus, real-world study
Authors: Gameil Mohammed Ali , Yousef Elshahat Ali Ahmed Mohamed , Marzouk Rehab Elsayed , Emara Mohamed H. , Abdelkader Abeer H. , Salama Rasha Ibrahim 
Published: December 2024

Abstract
Background and Aim
The association between biliary disorders with weight reduction enhanced by GLP-1RAs was observed frequently, nevertheless, the relative risk of the clinically relevant cholelithiasis was not specified clearly among different GLP-1RAs.

Methods
308 patients with type 2 diabetes mellitus (T2D) were recruited and divided into 4 groups; liraglutide, dulaglutide, semaglutide, versus control group; comprised of 69, 76, 71, and 92, respectively. Clinical history, examination, laboratory, and radiology tests were implemented.

Results
Cholelithiasis significantly associates GLP1-RAs (p = 0.033). Overall cholelithiasis was evident in 31.2% of our participants. Symptomatic cholelithiasis prevails in 60.4% of patients with cholelithiasis. Symptomatic complicated cholelithiasis prevailed in 33.3%; distributed in 28.1%, 28.1%, 21.9%, and 21.9% in liraglutide, semaglutide, dulaglutide, and control groups, respectively. Meanwhile, symptomatic uncomplicated cholelithiasis was observed in 27.1%; distributed in 34.6%, 30.8%, 15.4%, and 19.2% in Liraglutide, semaglutide, dulaglutide, and control groups, respectively. Asymptomatic cholelithiasis was noted in 36.8%, 21.1%, 10.5%, and 31.6% of patients with dulaglutide, semaglutide, liraglutide, and control groups, respectively. Specifically, 81.1%, 68%, and 44% of patients with liraglutide, semaglutide, and dulaglutide experienced symptomatic cholelithiasis. The relative risk of cholelithiasis was 1.2, 1.3, and 1.4 in liraglutide, dulaglutide, and semaglutide with number needed to harm of 17.25, 14.69, and 10.96, respectively. The relative risk of symptomatic cholelithiasis was 1.6, 0.9, and 1.4 in liraglutide, dulaglutide, and semaglutide with number needed to harm of 3.14, 16.67, and 5.56, respectively.

Conclusion
Liraglutide was associated with the highest risk of clinically relevant cholelithiasis than semaglutide, and dulaglutide in patients with T2D.
Effect of fluid and driving pressure on cyclical “on–off” flow of pulmonary microcirculation during mechanical ventilation
Authors: Yuan Siyi , Chen Xiangyu , Mi Liangyu , Chi Yi , Huang Haoping , Liu Bo , Yue Chaofu , Zhao Zeming , Su Longxiang , Long Yun , Akin Şakir , Ince Can , He Huaiwu 
Published: December 2024

Abstract
Objectives
This study aimed to identify the cyclical “on–off” flow of pulmonary microcirculation during inspiration and expiration by sidestream dark field imaging (SDF) technology in vivo and investigate the effects of volume status and driving pressure on cyclical “on–off” flow of microcirculation.

Methods
24 ARDS-modeled rabbits were randomly divided into high-driving pressure group (HDP group) and low-driving pressure group (LDP group). Lung microcirculation measurements were performed using the SDF microscope at two timepoints (T1 CVP 2–4 mmHg, T2 CVP 8–10 mmHg). From T1 to T2, 10 ml/kg saline was infused to increase CVP. The cyclical “on–off” pulmonary microcirculation was quantitatively assessed by the change of microcirculation between expiration and inspiration.

Results
Proportion of perfused vessels (PPV), microvascular flow index (MFI), perfused vessel density (PVD), and total vessel density (TVD) at expiration were significantly higher than inspiration in the HDP group. The HDP group has a higher ΔPPV and ΔPVD. After fluid loading, ΔPPV and ΔMFI decreased. TNF-α, IL-6, Ang-2, and vWF levels in the HDP group were higher. The HDP group also has a higher lung wet-weight/body weight ratio, lung wet-to-dry weight ratio, and more severe damage of pulmonary capillaries than the LDP group.

Conclusions
The difference in alveolar perfused microcirculation between inspiration and expiration defined as cyclical “on–off flow” can be detected. High driving pressure can enhance the cyclical “on–off” flow, and fluid loading can relieve it. High driving pressure can potentially cause injury to pulmonary capillaries due to the phenomenon of “on–off” flow, thereby exacerbating ARDS.
Diversity of Indonesian Lebaran dishes: from history to recent business perspectives
Authors: Prastowo Indro , Moro Hendro Kusumo Eko Prasetyo , Nurusman Arief Abdillah , Khoirunnisa Rikha Muftia , Dewi Cyntia , Sari Wahyu Wido , Yunita Ika Surya 
Published: December 2024

AbstractEid al-Fitr is one of the Islamic holidays celebrated by Muslims all over the world, including in Indonesia (Eid al-Fitr is popularly known as lebaran in Indonesia). Indonesia has long been recognized as a multicultural country with many cultural traditions, such as culinary traditions associated with particular religious holidays. This article aims to explore around 165 Indonesian Lebaran Dishes (ILDs) discussed from different points of view such as history, cultural traditions, geographical distribution, health and economic benefits of the preparation ILDs. Briefly, the research is a literature study in which data were collected from online and offline sources, triangulated with mini-interview (with open ended questions) before synthesized into a manuscript. The result of research was family dining banquets and nationwide tradition of Halal bi-halal often includes several ubiquitous ILDs such as ketupat, opor ayam, and lontong. Meanwhile, ILDs such as sie reuboh, nasi tutug oncom, and nasi jaha are usually served in makmeugang (Aceh), ngabotram (West Java), and binarundak (Gorontalo and North Sulawesi) traditions during lebaran, respectively. In the term of diversity, the 165 ILDs are discovered and widely distributed in 26 provinces, exhibiting a confluence of the Islamic faith with local and foreign culinary traditions. The ILDs are dominated by rice cakes (31 dishes), curries (26 dishes), stews (18 dishes), and cookies (18 dishes)—for example, ketupat kandangan (South Kalimantan), lontong sayur (West Sumatra), semur daging (Jakarta), and kue semprit (Nationwide), respectively. Additionally, IDLs offer a diverse array of nutritional components, including carbohydrates, fibers, proteins, and fats, while also exhibiting specific functional properties. For example, fermented foods like tape ketan (Nationalwide) have been shown to enhance digestion by introducing probiotic microbes into digestive system. Notably, the ILDs industry holds significant economic prospect as contributing up to US$ 348 billion to the national revenue by 2023, with an annual growth rate of 20–30%.This high profitable business can further socio-culturally facilitate the promotion of particular specialties to other people in different regions, enabling a cross-cultural exchange between regions.
Childhood risk factors and clinical and service outcomes in adulthood in people with intellectual disabilities
Authors: Perera B. , Mufti S. , Norris-Grey C. , Baksh A. , Totsika V. , Hassiotis A. , Hurks P. , van Amelsvoort T. 
Published: December 2024

Background
Adults with intellectual disability experience increased rates of mental health disorders and adverse mental health outcomes.

Aim
Explore childhood risk factors associated with adverse mental health outcomes during adulthood as defined by high cost of care, use of psychotropic medication without a severe mental illness and psychiatric hospital admissions.

Method
Data on 137 adults with intellectual disability were collected through an intellectual disability community service in an inner London borough. Childhood modifiable and non-modifiable risk factors were extracted from records to map onto variables identified as potential risk factors. Logistic and linear regression models were employed to analyse their associations with adverse outcomes.

Results
We showed that the co-occurrence of intellectual disability with autism spectrum disorder and/or attention-deficit hyperactivity disorder (ADHD) were associated with psychotropic medication use and high-cost care packages. However, when challenging behaviour during childhood was added, ADHD and autism spectrum disorder were no longer significant and challenging behaviour better explained medication prescribing and higher cost care. In addition, the severity of intellectual disability was associated with higher cost care packages. Ethnicity (Black and mixed) also predicted higher cost of care.

Conclusions
Challenging behaviour during childhood emerged as a critical variable affecting outcomes in young adulthood and mediated the association between adult adverse mental health outcomes and co-occurring neurodevelopmental conditions, that is, ADHD and autism. These findings emphasise the need for effective early intervention strategies to address challenging behaviour during childhood. Such interventions for challenging behaviour will need to take into consideration autism and ADHD.
Accelerometer-derived movement behaviours and risk of mortality among individuals with pre-existing depression: prospective cohort study
Authors: Duan Tingshan , Cao Zhi , Wang Xuemei , Min Jiahao , Sun Tao , Luo Hong , Xu Chenjie 
Published: December 2024

Background
Evidence is largely limited regarding the extent to which abnormal behavioural profiles, including physical inactivity, sedentary behaviour and inadequate sleep duration, impact long-term health conditions in individuals with pre-existing depression.

Aims
To investigate the associations between accelerometer-derived daily movement behaviours and mortality in individuals with pre-existing depression.

Method
Between 2013 and 2015, a total of 10 914 individuals with pre-existing depression were identified from the UK Biobank through multiple sources including self-reported symptoms, records of antidepressant usage and diagnostic recording based on the 10th Revision of the International Classification of Diseases (ICD-10) codes F32–F33. These participants were subsequently followed up until 2021. Wrist-worn accelerometers were used for objective measurement of sleep duration, sedentary behaviour, moderate-to-vigorous physical activity (MVPA) and light physical activity (LPA) over a span of seven consecutive days.

Results
During a median follow-up of 6.9 years, 434 deaths occurred among individuals with pre-existing depression. We observed a U-shaped association between sleep duration and mortality in individuals with pre-existing depression, with the lowest risk occurring at approximately 9 h/day. Both MVPA and LPA exhibited an L-shaped pattern in relation to mortality, indicating that engaging in higher levels of physical activity was associated with lower risk of mortality in individuals with pre-existing depression, but the beneficial effect reached a plateau after 50 min/day for MVPA and 350 min/day for LPA. We found a positive association between sedentary time and mortality, and the risk apparently increased above 8 h/day. Moreover, substituting 1 hour/day of sedentary time with LPA or MVPA was significantly associated with a 12% (hazard ratio: 0.88, 95% CI: 0.83–0.94) and 24% (hazard ratio: 0.76, 95% CI: 0.61–0.94) lower risk of mortality, respectively.

Conclusions
Our study found the beneficial effect of adequate sleep duration, high levels of physical activity and short sedentary time on risk of mortality among individuals with pre-existing depression.