bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proactive personality and its impact on online learning engagement through positive emotions and learning motivation
Authors: Fu Pingting , Gao Chengjin , Chen Xueyi , Zhang Zihao , Chen Jufeng , Yang Dong 
Published: November 2024

AbstractThe rapid change in information technology has made online or blended learning a new norm in higher education. However, the problem of low student engagement in online learning is becoming more prominent. This study explores how college students’ proactive personality affects their online learning engagement through the mediating effects of positive emotions and learning motivation. A survey was conducted on college students (N = 1049), and the interrelationships among these variables were analyzed using structural equation modeling. The findings unveiled that: proactive personality positively predicts online learning engagement, positive emotions and learning motivation. Positive emotions and learning motivation significantly positively influence online learning engagement. Moreover, Positive emotions also exert a significant positive impact on learning motivation. In addition, the mediation of positive emotions and learning motivation further strengthened a significant positive correlation between proactive personality and online learning engagement. Implications for theory and practice, including the limitations, were discussed accordingly.
Linguistic Markers of Subtle Cognitive Impairment in Connected Speech: A Systematic Review
Authors: Richard Amélie B. , Lelandais Manon , Reilly Karen T. , Jacquin-Courtois Sophie 
Published: November 2024

Purpose:
This systematic review covers the current stage of research on subtle cognitive impairment with connected speech. It aims at surveying the linguistic features in use to single out those that can best identify patients with mild neurocognitive disorders (mNCDs), whose cognitive changes remain underdiagnosed.

Method:
We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines and proposed a full definition of features for the analysis of speech features. Fifty-one studies met the inclusion criteria. Most of them focused on age-related progressive diseases and included fewer than 30 subjects.

Results:
A total of 384 features labeled with 335 different names was retrieved, yielding various results in discriminating individuals with mNCDs from controls.

Conclusions:
This finding highlights the need for harmonized labels to further investigate mNCDs with linguistic markers. We suggest two different ways of assessing a feature's reliability. We also point out potential methodological issues that remain to be resolved, along with recommendations for reproducible research in the field.
Anorexia Somato-Encephalica
Authors: Golder Werner Albert 
Published: November 2024

ZUSAMMENFASSUNGDie Anorexie war den Ärzten der Antike sowohl als Symptom als auch als eigenständige Erkrankung geläufig. Hippokrates sah in ihr noch ein ausschließlich somatisches Krankheitszeichen, das vor allem im Zusammenhang mit Dysenterie und Fieber beobachtet wurde. Rund 500 Jahre später hat Galen von Pergamon die Inappetenz und deren Ursachen und Folgen in 18 seiner Schriften zum Thema gemacht. Er betrachtete sie als potenziell multikausales Phänomen. Über Erkrankungen des Magens und der Leber und die Schwindsucht hinaus sah er auch in psychischen Störungen einen Grund für die Verweigerung der Nahrungsaufnahme. Das weibliche Geschlecht war dabei seiner Erfahrung nach viel häufiger betroffen als die Männer. In eindrucksvollen Kasuistiken schildert der Pergamener die dramatischen Symptome der Patientinnen und bezeichnet dabei die Kombination von Inappetenz und Amenorrhoe als charakteristisch für die mentale Variante der Anorexie.
Elektronische Befunddokumentation in der Sehbehindertenberatung mittels FIDUS-Software
Authors: Hornig Kerstin , Schiefer Ulrich , Ungewiss Judith 
Published: November 2024

Zusammenfassung
Hintergrund Der zunehmende Einsatz elektronischer Befunddokumentationen macht auch vor dem Bereich der Sehbehindertenberatung nicht Halt. Ziel des hier beschriebenen Vorhabens war es, ein Formularsystem und eine elektronische Patientenakte für den „Low-Vision“-Bereich zu entwickeln, die gleichermaßen im augenärztlichen, orthoptischen und auch augenoptisch-optometrischen Umfeld sowie in der studentischen Lehre genutzt werden können.
Patienten und Methoden Auf der Basis der in ophthalmologischen Praxen und Kliniken etablierten Software FIDUS (FIDUS Arztservice Wente GmbH, Darmstadt/D) wurden digitale Eingabemasken für die Sehbehinderten-Sprechstunde entwickelt – mit der Maßgabe möglichst großer Übersichtlichkeit, hohem Bedienkomfort (einschl. „Auto-fill-in“-Funktionalität, Auswahlempfehlungen und Bestandsmanagement vorhandener Sehhilfen) bei zusätzlich größtmöglicher Zeitersparnis.
Ergebnisse Dieser Beitrag stellt die Umsetzung dieser Kriterien anhand der elektronischen FIDUS-Karteikarte und der Sehbehindertenberatungs-Dokumentation mit den entsprechenden elektronischen Formularen dar. Hierbei visualisiert die Karteikarte auf den ersten Blick die wichtigsten Daten/Befunde des Patienten. Das speziell für die Sehbehindertenberatung gestaltete Untersuchungsformular erlaubt es, die Hilfsmittelversorgung ausführlich und dennoch zeitsparend zu dokumentieren. Weitere Formulare ermöglichen den direkten Ausdruck von Verordnungsempfehlungen, Testberichten oder Bescheinigungen. Die Eingabemasken können – in gedruckter Form – auch für eine konventionelle, handschriftliche Erfassung derartiger Daten genutzt werden.
Schlussfolgerungen Eine elektronische Dokumentation speziell für die Belange der ophthalmologisch-optischen Versorgung sehbehinderter Menschen, unter Berücksichtigung des lokalen Bestandsangebots, ist realisiert. Folgestudien sind erforderlich, um die untersucher-, patienten- und studierendenseitige Akzeptanz zu eruieren und die Software zu optimieren.
Strukturelle Hürden der Vergütung der kinderchirurgischen Behandlung
komplexer Fehlbildungen im Deutschen G-DRG System
Authors: Wilms Miriam , Schuster Horst , Krause Franz , Wolff Johannes , Boettcher Michael , Knoefel Wolfram Trudo , Jenetzky Ekkehart 
Published: November 2024

Zusammenfassung
Hintergrund  Komplexe Fehlbildungen erfordern eine ressourcenintensive
Versorgung. Vergütungsmuster der korrektiven Fehlbildungschirurgie wurden vor
dem Hintergrund der Versorgungslandschaft bisher nicht analysiert.
Methoden  Krankenhausabrechnungsdaten zu Korrekturoperationen von zehn
ausgewählten komplexen Fehlbildungen von 2020–2022 wurden analysiert. Nach dem
jährlichen Durchschnitt der Fallzahlen wurden Standorte in
Hochvolumenkrankenhäuser (HVK; mindestens 10 Fälle), Mittelvolumenkrankenhäuser
(MVK; mindestens 5 aber weniger als 10 Fälle), Niedrigvolumenkrankenhäuser (NVK;
mindestens 1 aber weniger als 5 Fälle) und in extreme
Niedrigvolumenkrankenhäuser (eNVK; mehr als 0 aber weniger als 1 Fall)
kategorisiert.
Ergebnisse  Von 2020–2022 wurden jährlich durchschnittlich 1429
Korrekturoperationen für die zehn komplexen Fehlbildungen in Deutschland an 158
Standorten erbracht. Der Case Mix Index (CMI) für diese Leistungen betrug 7,057.
Die Leistungserbringung war dezentral. Es gab vier HVK für anorektale
Malformation, drei HVK für Spina bifida, zwei HVK für kongenitale
Zwerchfellhernie und jeweils eines für Blasenekstrophie, Epispadie,
Gallengangsatresie und Morbus Hirschsprung. Es gab kein HVK für Gastrochisis,
Omphalozele oder Ösophagusatresie. 127 Standorte (80%) erreichten für keine der
Leistungen eine Mindestfallzahl von 5 Korrekturoperationen pro Jahr.
Fazit  Der CMI der korrektiven Fehlbildungschirurgie ist weit höher als
der CMI der allgemeinen „Kinder- und Jugendchirurgie“. Die Versorgungslandschaft
ist dezentral. Gelegenheitsversorgung stellt für Krankenhausstandorte ein
finanzielles Risiko dar.
ABC Family Gene Polymorphisms and Cognitive Functions Interact to
Influence Antidepressant Efficacy
Authors: Jin Meijiang , Ji Lei , Ran Maojia , Wang Zhujun , Bi Yan , Zhang Hang , Tao Yuanmei , Xu Hanmei , Zou Shoukang , Zhang Hong , Yu Tao , Yin Li 
Published: November 2024

Abstract
Introduction The importance of identifying relevant indicators of
antidepressant efficacy is highlighted by the low response rates to
antidepressant treatment for depression. The ABC gene family, encoding
ATP-dependent transport proteins facilitating the transport of psychotropic
drugs, has drawn attention. This study delved into the relationship between
antidepressant efficacy and seven single nucleotide polymorphisms of ABCB1 and
ABCB6 genes.
Methods A total of 549 depressed patients participated in the study, and
all completed a 6-week course of antidepressant treatment. Cognitive function
was assessed at baseline and post-treatment. Patients were categorized based on
post-treatment HAMD-17 scores (with HAMD≤7 indicating remission), and
comparisons were made between different groups in terms of allelic gene
frequencies and genotypes. Logistic regression was used to explore the
interaction between cognitive function and genotype on efficacy. Dual-luciferase
reporter assays were performed to compare the regulatory effects of rs1109866
allele variants on the ABCB6 promoter.
Results There were no notable differences in allelic gene frequencies and
genotypes between the remission and non-remission groups. Nonetheless, a
significant interaction was identified between the rs1109866 genotype and
language fluency-related indicators concerning efficacy (p=0.029) before
correction. The dual-luciferase reporter assays demonstrated markedly higher
fluorescence intensity of rs1109866-C compared to that of rs1109866-T
(p<0.001).
Discussion Relying solely on genetic polymorphisms of ABC family genes as
predictors of antidepressant treatment response may not be sufficient. However,
the interaction between the rs1109866 and cognition plays a pivotal role. The
potentially enhanced transcriptional activity of rs1109866-C might offer insight
into its impact on antidepressant efficacy.
Leaving the Patella Unresurfaced Does Not Increase the Risk of Short-Term Revision Following Total Knee Arthroplasty: An Analysis from the American Joint Replacement Registry
Authors: García Vélez Dencel A. , Buddhiraju Anirudh , Kagan Ryland , Zaniletti Isabella , De Ayushmita , Khanuja Harpal S. , Pelt Christopher E. , Hegde Vishal 
Published: November 2024

AbstractThe benefit of patellar resurfacing in total knee arthroplasty (TKA) remains uncertain, with conflicting evidence regarding associated revision rates and clinical outcomes. Although initial studies have reported higher revision rates associated with unresurfaced patellae, recent evidence questions the necessity of routine patellar resurfacing. This study aimed to evaluate the risk of revision following TKA performed with and without patellar resurfacing using data from the American Joint Replacement Registry (AJRR).The AJRR was queried for all patients aged 65 years and older undergoing elective TKA between January 2012 and March 2020 with a minimum 2-year follow-up. Cases were linked using supplemental Centers for Medicare and Medicaid data. Cases with hybrid fixation, highly constrained implants, and revision components were excluded. Patients were categorized into two groups: those with a resurfaced patella and those without. Cumulative incidence function (CIF) curves and cause-specific Cox models were utilized to assess all-cause revision risk, adjusting for sex, age, femoral design (cruciate retaining vs. posterior stabilized), fixation type (cemented vs. cementless), and Charlson Comorbidity Index.Of the 390,304 TKAs with minimum 2-year follow-up in our cohort, 22,829 had no patellar resurfacing performed. Adjusted hazard ratios (HRs) revealed no significant difference in all-cause revision (HR = 0.96, 95% confidence interval [CI]: 0.81–1.13, p = 0.656), revision for mechanical loosening (HR = 1.61 [0.88, 2.93], p = 0.122), or revision for infection (HR = 1.02 [0.79, 1.33], p = 0.860) associated with patellar resurfacing status.Our study found that patients with an unresurfaced patella do not face an increased short-term revision risk following TKA. These findings challenge the necessity of routine patellar resurfacing and underscore the importance of considering other factors, such as femoral design, patient comorbidities, and implant-related variables in revision risk stratification.
Services in Minoritized Autistic Adolescents and Adults Varying in Language Skills
Authors: Girolamo Teresa , Escobedo Alicia , Ghali Samantha , Greene-Pendelton Kyle , Campos Iván , Ram-Kiran Poornima 
Published: November 2024

AbstractRacially and ethnically minoritized (minoritized) autistic individuals face intersectional disparities in service access in the transition to adulthood. Our understanding of disparities is limited by systematic exclusion from research and inadequate approaches to characterizing services. To address these gaps and effect advocacy, this study (1) examined services received, unmet service needs, and barriers in minoritized autistic adolescents and adults and (2) determined if language, NVIQ, and autism traits predict services when deployed as binary or continuous variables. Academic and community partners tailored community-based participatory research (CBPR) to a local context. Participants (N = 73, ages 13–30) completed a behavioral assessment protocol. Participants and caregivers provided information on services received, unmet service needs, and barriers to services. Data were analyzed using descriptive and regression. Participants received multiple services yet had multiple unmet service needs and barriers. Effects of services differed by approach. Language impairment, but not language scores, predicted receiving more services. High levels of autism traits and autism trait scores predicted more unmet service needs. While the number of services and unmet service needs was similar to prior work, differences in individual service variables and effects support attention to heterogeneity. Findings support intersectional approaches to CBPR and autism research.
Cybercrime as an industry: examining the organisational structure of Chinese cybercrime
Authors: Luo Qiaoyu 
Published: November 2024

AbstractIn an age of advancing information technology, widespread internet access has facilitated a rise in profit-driven cybercrime. Empirical research has found that cybercrime is now highly industrialised. Cybercrime operations have evolved into an assembly of various malicious acts, some of which do not require advanced technical abilities. While extensive research on cybercrime has been conducted globally, there is a lack of detailed investigation into the cybercrime landscape in China, despite it being a vast economic entity with a significant number of cybercrime incidents. Drawing on interviews and secondary data from China collected between 2020 and 2022, this paper seeks to address this gap by offering a comprehensive examination of Chinese cybercrime. It explores the degree of industrialisation within Chinese cybercrime and discusses its impact on the work performed by Chinese cybercriminals. Echoing findings from previous studies on the industrialisation of cybercrime, the current study reveals an elaborate industry built around cyber fraud, populated by various market players working on diverse tasks to support the successful operation of cyber fraud. The research also uncovers the existence of cybercriminal firms that closely mimic the structural and operational approaches of legitimate companies. Similar to how the Industrial Revolution reshaped traditional manufacturing, the industrialisation of cybercrime has transformed it into an assembly line operation, where each cybercriminal carries out basic, tedious, and repetitive tasks on a daily basis.
H3Se in the

I
m

3
¯

m

Phase: High-Pressure Superconductor with Tc Reaching 200 K at 64 GPa Mediated by Anharmonic Phonons
Authors: Ma 马 Yao 遥 , Li 李 Mingqi 明奇 , Shi 史 Wenjia 文佳 , Wang 王 Vei 伟 , Hou 侯 Pugeng 朴赓 , Pang 庞 Mi 蜜 
Published: November 2024

Abstract
Hydrogen-based compounds have attracted significant attention in recent years due to the discovery of conventional superconductivity with high critical temperature under high pressure, rekindling hopes for finding room-temperature superconductors. In this study, we investigated the vibrational and superconducting properties of H3Se in the

I
m

3
¯

m

phase under pressures of 50–200 GPa. Our approach combines the stochastic self-consistent harmonic approximation and first-principles calculations to account for the quantum and anharmonic effects of ions. According to the results, these effects significantly modify the crystal structure, increasing the inner pressure by approximately 8 GPa compared to situations in which they are ignored. The phonon spectra suggest that when these effects are considered, the crystal stabilizes at pressures as low as approximately 61 GPa, which is significantly lower than the previously predicted value of over 100 GPa. Our calculations also highlight the critical role of quantum and anharmonic effects on the electron–phonon coupling properties. Neglecting these factors can result in a significant overestimation of the superconducting critical temperature (T
c) by approximately 4 K (200 GPa) to 25 K (125 GPa). With anharmonic phonons, the T
c calculated from the Migdal–Eliashberg equations reaches 200 K (μ* = 0.1, λ = 4.1) as the pressure decreases to 64 GPa, indicating that the crystal is a rare high-T
c superconductor at moderate pressures.
Pentameric Assembly Architecture of the Tail Tube Protein in SPR Phages
Authors: Wang Lin , He Yuhang , Zhu Kaixiang , Cui Sheng , Gao Xiaopan , Shang Kun , Zhu Hongtao 
Published: November 2024

Abstract
Most phages—viruses infecting prokaryotes—inject their genomes via a tail structure. The central tail tube, composed of tail tube protein (TTP), typically forms conserved hexameric or trimeric rings. In this paper, we report a novel pentameric TTP assembly, solved by cryo-electron microscopy (cryo-EM) at 3.5 Å and 3.7 Å resolution. Structural analysis reveals a highly negatively charged inner surface of this pentameric tube. Key residues in the loop connecting β3 and β4 strands are crucial for pentameric ring formation. Mismatches in interactions between stacked layers can induce curvature in the tube. The cryo-EM structure of the TTP polymer at the tube’s end shows that β-strands spanning amino acids 27–65 shift toward the central tunnel, potentially obstructing the passage of the phage genome. This study provides new structural insights into a unique TTP assembly, enhancing our understanding of phage assembly processes.
Antitumoral action of carvedilol–a repositioning study of the drug incorporated into mesoporous silica MCM-41
Authors: Braz Wilson Rodrigues , de Souza Maria Gabriela Martins , da Silva Liziane Marçal , de Azevedo Caroline Borges , Ribeiro Arthur Barcelos , Barbosa Denise Crispim Tavares , Molina Eduardo Ferreira , de Faria Emerson Henrique , Ciuffi Katia Jorge , Rocha Lucas Alonso , Martins Carlos Henrique Gomes , Santiago Mariana Brentini , Santos Anna Lívia Oliveira , Nassar Eduardo José 
Published: November 2024

Abstract
We have studied repositioning of carvedilol (an antihypertensive drug) incorporated into MCM-41 mesoporous silica. The repositioning proposes a reduction in the slow pace of discovery of new drugs, as well as toxicological safety and a significant reduction in high research costs, making it an attractive strategy for researchers and large pharmaceutical companies. We obtained MCM-41 by template synthesis and functionalized it by post-synthesis grafting with aminopropyltriethoxysilane (APTES) only or with folic acid (FA), which gave MCM-41-APTES and MCM-41-APTES-FA, respectively. We characterized the materials by scanning and transmission electron microscopy, zeta potential (ZP) measurements, Fourier transform infrared absorption spectroscopy, x-ray diffractometry, nitrogen gas adsorption, and CHNS elemental analysis. We quantified the percentage of drug that was incorporated into the MCM-41 materials by thermogravimetric analysis and evaluated their cytotoxic activity in non-tumor human lung fibroblasts and the tumor human melanoma and human cervical adenocarcinoma cell lines by XTT salt reduction (2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-arboxanilide). The x-ray diffractograms of the MCM-41 materials displayed low-angle peaks in the 2θ range between 2° and 3°, and the materials presented type IV nitrogen adsorption isotherms and H2 hysteresis typical of the MCM-41hexagonal network. The infrared spectra, the charge changes revealed by ZP measurements, and the CHN ratios obtained from elemental analysis showed that MCM-41 was amino-functionalized, and that carvedilol was incorporated into it. MCM-41-APTES incorporated 23.80% carvedilol, whereas MCM-41 and MCM-41-APTES-FA incorporated 18.69% and 12.71% carvedilol, respectively. Incorporated carvedilol was less cytotoxic to tumor and non-tumor cells than the pure drug. Carvedilol repositioning proved favorable and encourages further studies aimed at reducing its cytotoxicity to non-tumor cells. Such studies may allow for larger carvedilol incorporation into drug carriers or motivate the search for a new drug nanocarrier to optimize the carvedilol antitumoral activity.
Gain sensitivity of the Mach–Zehnder interferometer by photon subtraction
Authors: Podoshvedov Mikhail S , Podoshvedov Sergey A 
Published: November 2024

Abstract
The phase sensitivity of a Mach–Zehnder (MZ) interferometer with a two-mode squeezed vacuum (TMSV) probe state is studied. At the initial stage, the TMSV state is deterministically converted into two single-mode squeezed vacuum (SMSV) states, from each of which photons are subtracted via photon-number resolving measurement in auxiliary measurement modes. The new probe state can already demonstrate gain sensitivity of more than 20 dB with input squeezing of 5 dB and follow Heisenberg scaling. The phase sensitivity of the MZ interferometer, estimated by measuring the intensity difference of two measurement-induced continuous variable states, can surpass the ultimate one with SMSV probe states, at least, with squeezing less than 5 dB. In general, the strategy with preliminary subtraction of photons significantly increases the estimate potential of weakly squeezed states as the probe in MZ phase-dependent interferometry; in particular, it is more effective compared to generating highly squeezed TMSV states or SMSV states.
Interparticle-friction-induced anomalous colloid structure
Authors: Liu 刘 Fuzhou 福洲 , Ding 丁 Yu 宇 , Li 黎 Longfei 龙飞 , Cheng 程 Ke 可 , Ye 叶 Fangfu 方富 , Yang 杨 Mingcheng 明成 
Published: November 2024

Abstract
Interparticle frictional interactions are ubiquitous in colloidal systems, exerting a profound influence on their structural and physical attributes. In this study, we employed Brownian dynamics simulations to explore the non-equilibrium dynamics in colloidal systems, focusing particularly on the role of tangential friction and its influence on the macroscopic physical properties of colloids. We found that the disruption of instantaneous time-reversal symmetry by tangential frictional interactions can trigger the self-assembly of colloidal systems into intricate network configurations, and these novel structures exhibit unique depletion force and rheological properties that set them apart from traditional colloidal gel systems. These findings not only help deepen our comprehension of the self-assembly phenomena in non-equilibrium colloidal systems but also offer fresh insights for the development of colloidal materials with tailored characteristics.