bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kaempferide prevents cognitive decline via attenuation of oxidative stress and enhancement of brain‐derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element‐binding signaling pathway
Authors: Yan Tingxu , He Bosai , Xu Mengjie , Wu Bo , Xiao Feng , Bi Kaishun , Jia Ying 
Published: January 2019

Kaempferide (KF) is a compound of flavonoids from Alpinae oxyphylla Miq, and the herb itself is used as a classical tonic agent. This paper aims to investigate the effects of KF on cognitive function impairment and neurodegeneration in the mouse model of Alzheimer's disease induced by intracerebroventricular (ICV) injection of Aβ1–42. The mice were treated with KF at doses of 0.02 and 0.2 mg/kg/day (ICV) for five consecutive days after Aβ1–42 exposures. The behavioral test results showed that KF could prevent cognitive decline in mice induced by Aβ1–42 as assessed by the locomotor activity test, Y‐maze test, and Morris water maze test. Furthermore, the activities of superoxide dismutase and malondialdehyde in the hippocampus and cerebral cortex were elevated by KF administration. Results of hippocampus slices showed that neurons were integrated and regularly arranged in the groups, which were administered along with KF. In addition, we found KF could boost brain‐derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element‐binding (CREB) protein signal in the hippocampus. All results illustrated that KF could exert neuroprotective effects at least partly through alleviating oxidative stress and enhancing the BDNF/TrkB/CREB pathway in Aβ1–42‐induced mice.
Systematic decomposition of the MJO and its Northern Hemispheric extratropical response into Rossby and inertio‐gravity components
Authors: Franzke Christian L. E. , Jelic Damjan , Lee Sukyoung , Feldstein Steven B. 
Published: January 2019

The Madden–Julian Oscillation (MJO) is the dominant form of intraseasonal variability in the Tropics. The MJO is a complex convectively coupled phenomenon, which is still poorly represented in the current generation of climate models, and our understanding of its essential dynamics and its influence on the midlatitude circulation is still incomplete. Here, we use a normal‐mode decomposition method to decompose the MJO systematically into Kelvin, inertio‐gravity (IG), and Rossby‐wave components in the ERA‐Interim reanalysis data for the period 1980–2015 to provide a climatology of the eight MJO phases for the Kelvin, IG, and Rossby‐wave components.Our analysis shows that the Rossby modes provide a larger contribution to the magnitude of the MJO in terms of geopotential height and winds than the Kelvin wave and IG modes. Moreover, the kinetic energy associated with the Rossby modes of the MJO accounts for about 93% of the kinetic energy. Our decomposition also shows that the Kelvin wave is the dominant mode in the unbalanced wave part, which is flanked by Rossby waves on both sides of the Equator, consistent with previous studies. The extratropical response to the MJO also consists of both IG and Rossby‐wave components in the Northern Hemisphere (NH). The midlatitude MJO response is also linked to well‐known teleconnection patterns like the North Atlantic Oscillation and the Pacific–North American pattern. The transient NH atmospheric response is fast, of the order of 5–7 days. While the extratropical response is dominated by Rossby waves, IG waves also show a prominent response in the NH.
Comparison of data‐acquisition methods for the identification and quantification of histone post‐translational modifications on a Q Exactive HF hybrid quadrupole Orbitrap mass spectrometer
Authors: Cole Joby , Hanson Eleanor J. , James David C. , Dockrell David H. , Dickman Mark J. 
Published: January 2019

RationaleHistone post‐translational modifications (PTMs) play key roles in regulating eukaryotic gene expression. Mass spectrometry (MS) has emerged as a powerful method to characterize and quantify histone PTMs as it allows unbiased identification and quantification of multiple histone PTMs including combinations of the modifications present.MethodsIn this study we compared a range of data‐acquisition methods for the identification and quantification of the histone PTMs using a Q Exactive HF Orbitrap. We compared three different data‐dependent analysis (DDA) methods with MS2 resolutions of 120K, 60K, 30K. We also compared a range of data‐independent analysis (DIA) methods using MS2 isolation windows of 20 m/z and DIAvw to identify and quantify histone PTMs in Chinese hamster ovary (CHO) cells.ResultsThe increased number of MS2 scans afforded by the lower resolution methods resulted in a higher number of queries, peptide sequence matches (PSMs) and a higher number of peptide proteoforms identified with a Mascot Ion score greater than 46. No difference in the proportion of peptide proteoforms with Delta scores >17 was observed. Lower coefficients of variation (CVs) were obtained in the DIA MS1 60 K MS2 30 K 20 m/z isolation windows compared with the other data‐acquisition methods.ConclusionsWe observed that DIA which offers advantages in flexibility and identification of isobaric peptide proteoforms performs as well as DDA in the analysis of histone PTMs. We were able to identify 71 modified histone peptides for histone H3 and H4 and quantified 64 across each of the different acquisition methods.
FOXD3 Suppresses Tumor-Initiating Features in Lung Cancer via Transcriptional Repression of WDR5
Authors: Xu Wei , Li Jialin , Li Lei , Hou Tianhui , Cai Xiaopan , Liu Tielong , Yang Xinghai , Wei Haifeng , Jiang Cong , Xiao Jianru 
Published: January 2019

Abstract
The tumor-initiating cells (TICs) are a cell population that can initiate tumor occurrence, mediate drug resistance, and give rise to metastasis. FOXD3 is a forkhead box (Fox) transcription factor family that regulates the pluripotency of embryonic stem cell and tumorigenicity. However, it is unclear whether FOXD3 plays any role in TIC and tumor metastasis. The functional analysis of FOXD3 was performed by oncospheres formation and redifferentiation, drug resistance assay, and cell migration. Global genomic RNA-Seq and ChIP-Seq analysis were used to identify the direct target of FOXD3 in lung cancer. We demonstrated that downregulation of FOXD3 in TICs was positively correlated with higher histologic grades and positive lymph node metastasis. FOXD3 repressed TIC expansion and cell migration, drug resistance, and osteoclasts in vitro and in vivo. Mechanically, we found that FOXD3 represses WDR5, which regulates TIC-related signaling pathway. Moreover, WDR5 were positively correlated with the TIC abundance and tumor progression. Besides, patients with high expression of WDR5 presented a poorer overall survival. FOXD3 may suppress TIC accumulation by repressing the expression of WDR5 in lung cancer. Stem Cells 2019;37:582–592
Impact of wall roughness and turbulence level on the performance of a horizontal axis wind turbine with the U‐RANS solver THETA
Authors: Länger‐Möller Annika 
Published: January 2019

AbstractThe presented work investigates the impact of different sheared velocity profiles in the atmospheric boundary layer on the characteristics of a wind turbine by modifying the wall roughness coefficients in the logarithmic velocity profile. Moreover, the rotor and wake characteristics in dependence of the turbulence boundary conditions are investigated. In variant I, the turbulence boundary conditions are defined in accordance to the logarithmic velocity profile with different wall roughness lengths. In variant II, the turbulent kinetic energy and turbulent viscosity remain independent of the velocity profile and represent the free‐stream turbulence level.With an increase of the shear in the velocity profile, the amplitudes in the 3/rev characteristics of rotor thrust and rotor torque, induction factors, and effective angles of attack are increased. In variant I, the overall levels of thrust coefficient are hardly affected by the velocity profiles resulting from different wall roughness length values. The power coefficient is reduced about 1%. Conversely, compared with variant II, a difference of 2% in the power coefficient has been detected. Moreover, the wake recovery process strongly depends on the turbulence boundary condition. Simulations are carried out on an industrial 900‐kW wind turbine with the incompressible U‐RANS solver THETA.
Using Local Rural Knowledge to Enhance STEM Learning for Gifted and Talented Students in Australia
Authors: Morris Julia , Slater Eileen , Fitzgerald Michael T. , Lummis Geoffrey W. , van Etten Eddie 
Published: January 2019

AbstractIn order to supply a future Science, Technology, Engineering, and Mathematics (STEM) workforce, Australia needs to engage its most capable and gifted secondary students in quality STEM learning, either within school or through extra-curricular opportunities, so that they will continue into STEM-based tertiary degrees. High-achieving students in rural communities may face additional barriers to STEM learning that can limit their ability to pursue advanced STEM studies and occupations. This small-scale research project sought to explore a group of gifted lower secondary students’ engagement and experiences in a STEM programme designed around a local rural knowledge model as reported by Avery (2013), which uses local knowledge as a vehicle for science learning. This multi-method study was conducted with 26 students years 7 and 8 in a rural school. Information about students’ general science class experiences were collected quantitatively. These experiences contrasted the local rural knowledge programme, where the students worked with an ecologist and experienced science educators to rehabilitate small plots of damaged land close to the school site. Qualitative data were collected throughout the programme to determine its influence on students’ engagement and learning in STEM. The research found that the local rural knowledge model enhanced students’ engagement in STEM learning and they felt that they retained knowledge better as a result of the authentic learning experience. Students also engaged the wider community in the process, leading to broader translation of the STEM learning.
Air-temperature control on diurnal variations in microseismicity at Laohugou Glacier No. 12, Qilian Mountains
Authors: Zhang Tao , Chen Yuqiao , Ding Min , Shen Zhongyan , Yang Yuande , Guan Qingsheng 
Published: January 2019

ABSTRACTWe conducted a 9-d seismic experiment in October 2015 at Laohugou Glacier No. 12. We identified microseismic signals using the short-term/long-term average trigger algorithm at four stations and classified them as long and short-duration events based on waveform, frequency, duration and magnitude characteristics. Both categories show systematical diurnal trends. The long-duration events are low-frequency tremor-like events that mainly occurred during the daytime with only several events per day. These events lasted tens of seconds to tens of minutes and are likely related to resonance of daytime meltwater. The dominant short-duration events mostly occurred during the night time with a peak occurrence frequency of ~360 h−1. Their short-duration (<0.2 s), high frequency (20–100 Hz) and dominance of Rayleigh waves are typical of events for near-surface crack opening. A strong negative correlation between the hourly event number and temperature change rate suggests that the occurrence of night-time events is controlled by the rate of night-time cooling. We estimated the near-surface tensile stress due to thermal contraction at night to be tens of kilopascals, which is enough to induce opening of surface cracks with pre-existing local stress concentrations, although we cannot exclude the effect of refreezing of meltwater produced during the day.
Delayed transplanting reduced grain yield due to low temperature stress at anthesis in machine-transplanted late-season rice
Authors: Huang Min , Fang Shengliang , Shan Shuanglü , Zou Yingbin 
Published: January 2019

AbstractThe development of mechanised large-scale farming has led to changes in rice production systems. Increases in time of farming operations often occur under large-scale farming conditions, which can lead to delayed transplanting (DTP). In this study, field experiments were conducted in the late rice-growing season in 2016 and 2017 to compare the growth stages, growing-season temperature and yield attributes between normal transplanting with 15- to 20-day-old seedlings and DTP with 30-day-old seedlings of two rice cultivars. DTP resulted in 6- and 12-day delays in heading stage for both cultivars in 2016 and 2017, respectively. As a consequence, low temperature stress occurred at anthesis under DTP in both years, which led to significantly reduced spikelet filling and grain yield under DTP for both cultivars. These results confirm that DTP can reduce spikelet filling and grain yield due to low temperature stress at anthesis in machine-transplanted late-season rice. This finding highlights that greater efforts should be made to develop high-yielding short-duration rice cultivars to meet the development of mechanised large-scale rice farming.
Against a Continental Threat: Transnational Anti-Communist Networks of the Chilean Right Wing in the 1950s
Authors: Casals Marcelo 
Published: January 2019

AbstractDrawing on minutes, publications, diplomatic documents and the written press, I explore the transnational networks of the Chilean right wing within Latin America in the 1950s, especially around the four Congresses against Soviet Intervention in Latin America held in Mexico City, Rio de Janeiro, Lima and Antigua between 1954 and 1958. I argue that the Chilean right wing's participation in those networks alongside other Latin American like-minded actors was based on both its long local experience in fighting communism and its attachment to Cold War anti-communism. In these transnational spaces, some Chilean right-wingers gained recognition and prestige, as was the case with the conservative leader Sergio Fernández Larraín, largely thanks to his systematic denunciation of supposed Soviet penetration in the Movimiento Nacionalista Revolucionario (MNR), then the ruling party in Bolivia.
Interrupted Sovereignties in the North-East Frontier of British India, 1787–1870
Authors: RAY REEJU 
Published: January 2019

AbstractThe Khasi, Jaintia, and Garo Hills in the North East Frontier of British India were subject to shifting and differentiated forms of colonial governance. Defying notions of coexistence with or autonomy from colonial rule, the colonial history of this region was bound up with specific spatio-temporal constructions. By examining the nature of jurisdictional and political encounters in the Khasi, Jaintia, and Garo Hills, this article addresses the interruptions to imperial sovereignty in the Frontier. Imperial sovereignty moved in juridical forms, affecting and being affected by classificatory challenges such as hills and plains, hill tribal, and settler. The relationship between jurisdictional boundaries, plural authority, and imperial sovereignty appears in judicial and revenue files of different levels of the English East India Company government and the British government. Recurrent boundary disputes between the spatio-temporal units of hills and plains during the late eighteenth and late nineteenth centuries point towards contingent strategies of governance. The unfolding of these disputes over the course of the nineteenth century also show that law and jurisdiction as carriers of imperial sovereignty were spatially and temporally uneven. The historical processes highlighted in this article concern the sub-region of Khasi, Jaintia, and Garo Hills and parts of the Sylhet district of British Bengal, which, at present, constitute the Indian state of Meghalaya and parts of northern Bangladesh, respectively.
The Problem of Periodization in the History of International Law
Authors: de la Rasilla Ignacio 
Published: January 2019

The first part of the article presents a six-tiered typology of conventional approaches to historical periodization in international law. The “hegemonic” approach, the “Eurocentric universalist” approach, the “state-centric” approach, the “intellectual doctrinal” approach, the “institutional” approach, and the “normative” approach to the question of periodization of the history of international law are surveyed in turn in the light of contemporary literature. The second part examines how in the wake of the recent “historical turn” in international law a new critical historiographical wave has problematized the question of periodization because of the homogenizing effects and the “teleology of progress” to which periodization is interpreted to contribute in international legal history. The third part tackles the notion of “alternative periodization” illustrating, with examples from contemporary literature in the history of international law, its value as a launching pad for the “formation of new, formerly unknown periods,” a task that is considered “an essential part of historiographical innovation.” The conclusion elaborates on the heuristic potential of a multiperspectival approach to the study of periodization in the history of international law.Saepe stilum vertas,iterum quae digna legi sunt scripturusHor., Sat. 1, 10, 72
HOHFELD VS. THE LEGAL REALISTS
Authors: Frydrych David 
Published: January 2019

ABSTRACT2018 marked the centenary of Wesley Hohfeld's untimely passing. Curiously, in recent years quite a few legal historians and philosophers have identified him as a Legal Realist. This article argues that Hohfeld was no such thing, that his work need not be understood in such lights either, and that he in fact made a smaller contribution to jurisprudence than is generally believed. He has nothing to do with theories of official decision-making that identify, among other things, “extra-legal” factors as the real drivers of judicial decision-making, nor must his schema of jural relations advance a “Realist” political agenda. Distinguishing Hohfeld from the Realists will help to correct some misunderstandings about his work and point to its utility in many more contexts than a Realist reading of it allows.
DF-Fit: A Robust Algorithm for Detection of Crystallographic Information in Atom Probe Tomography Data
Authors: Haley Daniel , Bagot Paul A. J. , Moody Michael P. 
Published: January 2019

AbstractWe report on a new algorithm for the detection of crystallographic information in three-dimensional, as retained in atom probe tomography (APT), with improved robustness and signal detection performance. The algorithm is underpinned by one-dimensional distribution functions (DFs), as per existing algorithms, but eliminates an unnecessary parameter as compared to current methods.By examining traditional DFs in an automated fashion in real space, rather than using Fourier transform approaches, we utilize an error metric based upon the expected value for a spatially random distribution for detecting crystallography. We show cases where the metric is able to successfully obtain orientation information, and show that it can function with high levels of additive and displacive background noise. We additionally compare this metric to Fourier transform methods, showing fewer artifacts when examining simulated datasets. An extension of the approach is used to aid the automatic detection of high-quality data regions within an entire dataset, albeit with a large increase in computational cost.This extension is demonstrated on acquired aluminum and tungsten APT datasets, and shown to be able to discern regions of the data which have relatively improved spatial data quality. Finally, this program has been made available for use in other laboratories undertaking their own analyses.
Effects of maize residue and mineral nitrogen applications on maize yield in conservation-agriculture-based cropping systems of Southern Africa
Authors: Mupangwa W. , Thierfelder C. , Cheesman S. , Nyagumbo I. , Muoni T. , Mhlanga B. , Mwila M. , Sida T. S. , Ngwira A. 
Published: January 2019

AbstractConservation agriculture (CA) and no-till (NT)-based cropping systems could address soil degradation and fertility decline in southern Africa. A multi-location and multi-year experiment was carried out between 2008 and 2014 to assess the effects of different levels of maize residue biomass (0, 2, 4, 6 and 8 t ha−1) and nitrogen (N) fertilizer (0, 30, 90 kg ha−1) on maize performance under no-tillage. In some sites, different (N) fertilizer levels were superimposed to test their effects on maize grain yield and leaf chlorophyll content under different maize residue biomass levels. The different residue levels had no significant effect on maize yield in most growing seasons. Maize residue cover increased grain yield in eight out of 39 site-years across the sites used. However, in some sites, maize yield decreased with increases in residue level in cropping seasons that had average to above average rainfall. At a few sites maize yield increased with increase in residue level. Seasonal rainfall pattern influenced the effect of different residue levels on grain yield at most sites. Nitrogen fertilizer increased maize yield regardless of the residue level applied. This study demonstrates that mulching with maize residues in CA/NT systems results in limited maize yield gains – at least within the first 6 years in different agro-ecological conditions of southern Africa.
Developing Daily Cloud‐Free Snow Composite Products From MODIS and IMS for the Tienshan Mountains
Authors: Li Y. , Chen Y. , Li Z. 
Published: January 2019

AbstractDaily cloud‐free snow cover products are important premise and foundation for hydrological simulation, climate system research, and snow disaster monitoring in the Tienshan Mountains, Central Asia. In this study, partial clouds appearing in the Moderate Resolution Imaging Spectroradiometer (MODIS) were removed by temporal and spatial filtering, and the remaining cloud pixels were replaced by Interactive Multisensor Snow and Ice Mapping System (IMS). The results show that the retrieved annual mean snow cover obtained from the improved MODIS product data is 31.5% higher than the original MODIS product. Through validation performed via in situ observations, the overall accuracy, land accuracy, and snow accuracy also increased to 88.2%, 91.9%, and 81.9%, respectively. However, the overall accuracy shows a lower accuracy in transitional months compared to other months, which derives mainly from the difference in spatial scales between IMS and in situ observations.