bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Molecular Diversity Scope of Urazole in the Synthesis of Organic Compounds
Authors: Ziarani Ghodsi M. , Mohajer Fatemeh , Moradi Razieh , Mofatehnia Parisa 
Published: September 2019

Background:
As a matter of fact, nitrogen as a hetero atom among other atoms has had an
important role in active biological compounds. Since heterocyclic molecules with nitrogen are highly
demanded due to biological properties, 4-phenylurazole as a compound containing nitrogen might be
important in the multicomponent reaction used in agrochemicals, and pharmaceuticals. Considering the case
of fused derivatives “pyrazolourazoles” which are highly applicable because of their application for analgesic,
antibacterial, anti-inflammatory and antidiabetic activities as HSP-72 induction inhibitors (I and III) and novel
microtubule assembly inhibitors. It should be mentioned that spiro-pyrazole also has biological activities like
cytotoxic, antimicrobial, anticonvulsant, antifungal, anticancer, anti-inflammatory, and cardiotonic activities.

Objective:
Urazole has been used in many heterocyclic compounds which are valuable in organic syntheses.
This review disclosed the advances in the use of urazole as the starting material in the synthesis of various
biologically active molecules from 2006 to 2019.

Conclusion:
Compounds of urazole (1,2,4-triazolidine-3,5-dione) are the most important molecules which are
highly active from the biological perspective in the pharmaceuticals as well as polymers. In summary, many
protocols for preparations of the urazole derivatives from various substrates in multi-component reactions
have been reported from different aromatic and aliphatic groups which have had carbonyl groups in their
structures. It is noted that several catalysts have been synthesized to afford applicable molecules with urazole
scaffolds. In some papers, being environmentally friendly, short time reactions and high yields are highlighted
in the protocols. There is a room to synthesize new catalysts and perform new reactions by manipulating
urazole to produce biologically active compounds, even producing chiral urazole component as many groups
of chiral urazole compounds are important from biological perspective.
A Concept of Captcha Based Dynamic Password
Authors: Haque Md. Asraful , Ahmad Tauseef 
Published: September 2019

Background:
The conventional text passwords are by far the main means of authentication
and they will continue to be popular as they are easy to deploy and to use. However, they have
been largely exposed to different kind of attacks like guessing, phishing and key-logger attacks.

Objective:
It is efficient to use both CAPTCHA and text password in a user authentication to create
an additional layer of security over the passwords. Captcha and password work side by side and independently
in such captcha-assisted systems. Captcha filters out the suspicious programs from the
human beings and password recognizes the legitimate user among the human beings.

Method:
In this paper, we have suggested a dynamic password scheme combining the traditional
text password and captcha. User authentication will be verified by different passwords at different
login session based on the captcha presentations.

Results:
Suggested method does not replace the conventional password process rather than modifying
it. Therefore, users’ current sign-in experience is largely preserved. It will be implemented in
software alone, increasing the potential for large-scale adoption on the Internet.

Conclusion:
The scheme is easy to implement and will be useful to improve the security to a great
extent.
A Behavioral Activation Mobile Health App for Smokers With Depression: Development and Pilot Evaluation in a Single-Arm Trial
Authors: Heffner Jaimee L , Watson Noreen L , Serfozo Edit , Mull Kristin E , MacPherson Laura , Gasser Melissa , Bricker Jonathan B 
Published: September 2019

Background
The integration of Behavioral Activation Treatment for Depression (BAT-D) into smoking cessation interventions is a promising approach to address depression as a barrier to quitting. However, this approach has only been tested as a face-to-face intervention, which has low reach.

Objective
The aims of the study were to develop a BAT-D mobile health app with high potential reach and determine its feasibility, acceptability, and preliminary effects on theory-based behavioral processes of behavioral activation, reduced depressive symptoms, and smoking cessation.

Methods
Following a user-centered design process consisting of competitive analysis, focus groups, and prototype testing, we conducted a single-arm pilot trial of Actify!, a BAT-D app for depressed smokers. Participants used SmokefreeTXT along with Actify! to provide cessation content that had not yet been built into the app for this initial phase of pilot testing. Participants in the trial were current, daily smokers with mild to moderate depressive symptoms. We examined use outcomes for all enrolled participants and process and cessation outcomes at 6 weeks postenrollment for study completers (16/17, 94% retention).

Results
Regarding acceptability, average number of log-ins per participant was 16.6 (SD 13.7), and 63% (10/16) reported being satisfied overall with the app. Posttreatment interviews identified some usability challenges (eg, high perceived burden of planning and scheduling values-based activities). There was a significant decrease in depressive symptoms from baseline to follow-up (mean change in Patient Health Questionnaire–9 scores was –4.5, 95% CI –7.7 to –1.3; P=.01). Additionally, carbon monoxide (CO)-confirmed, 7-day point prevalence abstinence (PPA) at 6-week follow-up was 31% (5/16), and the 30-day PPA was 19% (3/16).

Conclusions
Results demonstrate promising engagement with Actify! and potential for impact on theory-based change processes and cessation outcomes. Preliminary quit rates compare favorably to previous trials of smoking cessation apps for the general population (ie, short-term, self-reported 30-day quit rates in the 8% to 18% range) and a previous trial of face-to-face BAT-D for depressed smokers (ie, CO-confirmed, 7-day PPA rate of 17% at end of treatment).
Optimalisasi Motivasi Berprestasi Dan Pendidikan Karakter Dampaknya Terhadap Prestasi Belajar Materi Himpunan Melalui Pendekatan Konstruktivisme Pada Siswa Kelas VII D SMP Negeri 3 Teras Kabupaten Boyolali Semester Gasal Tahun Pelajaran 2014/2015
Authors: Suryana Muh. Fakhrudin 
Published: September 2019

The purpose of the study is describing the achievement motivation, charac- ter education, and learning achievement. The research subject are 30 students of VII D grade, SMP Negeri Teras Boyolali. Data collection method used observation, ques- tionnaires, documentation, and testing. Data analysis used a critical and comparative analysis. Indicators of learning success is passing grade, Research procedures and 100% class attedance used cycles. Results of research and discussion shows that: 1) Consrtruc- tivism approach, help optimising the readiness of teachers in the learning of the initial conditions to the first cycle of 17.1%, then from the first cycle to cycle II, an increase of 30% as well as from the initial condition to a second cycle of 47.1%; 2) Through consrtructivism approach can optimize the preparation class for learning from the initial conditions to the first cycle of 26%, then from the first cycle to the second cycle there is an increase of 22% as well as from the initial condition to the second cycle by 48%;3) Through consrtructivism approach can optimize the achievement motivation of the initial conditions to the first cycle there is an increase student achievement of grade of 23%, from the first cycle to cycle II, an increase of 20%, and of the initial conditions of the second cycle to an increase of 43%; 4) Consrtructivism approach can optimize the educational character of the initial conditions to the first cycle there is an increase of 13% grade achievement, from the first cycle to cycle II, an increase of 20%, and of the initial conditions of the second cycle to an increase of 33%; 5) Consrtructivism approach can optimize student achievement of the initial conditions to the first cycle there is an increase of 20% grade achievement, from the first cycle to cycle II, an increase of 20%, and of the initial conditions of the second cycle to an increase of 40%; 6) through kon- srtruktivisme approach can optimize achievement motivation, character education, and mathematics achievement assemblage material, because students are able to construct their own knowledge, although it can not be separated from the guidance of a teacher
Peningkatan Kemampuan Pemecahan Masalah Prediksi Soal-Soal Ujian Nasional Mata Pelajaran Matematika Melalui Pendekatan Jigsaw Pada Peserta Didik Kelas IX A SMP Negeri 4 Boyolali Semester Genap Tahun Pelajaran 2012/2013
Authors: Wahyuni Sri 
Published: September 2019

The purpose of this study was to describe the optimization problem solving skills predictions about national exam mathematics courses through Jigsaw approach at a ninth grade students of State Junior High School 4 Boyolali. Subject and source of research data were do students of class IX A. The methods of collecting data were questionnaires, documentation, and test. Data were analyzed using a critical and comparative analysis. Indicators of success or graduation used criteria 5.5 (scale 4) or 55 (scale 100) and a target of 100% completion. The procedure used a classroom action research study conducted in three cycles, the first cycle was as initial condition, while the second and third cycles were as action. The results of research suggest that: (1) the motivation of participants students in learning mathematics courses before cycle can be described increase in the result, namely from before cycle to the first cycle, an increase of before cycle is average of 56 to the first cycle of an average of 58 (4%), of the first cycle an average of 58 the second cycle to an average of 79 of 21 (36%). Thus, the higher motivation of learners shows an impact on learning outcomes. While the mathematics learning outcomes can be described increase in the result, namely from before cycle to the first cycle, an increase of before cycle average of 45 to the first cycle an average of 59 of 14 (31%), from the first cycle an average of 59 to the second cycle mean average 69 of 10 (17%). Finally it can be said that using jigsaw for optimization problem solving skills predictions about national exam mathematics courses is recommended.
Neutron Characterization of BNCT Water Phantom Based on Kartini Research Reactor Using PHITS
Authors: Hutaria Vika , Susilo Susilo , Sardjono Yohannes 
Published: September 2019

Boron Neutron Capture Therapy (BNCT) is a therapy that utilizes the interaction of thermal neutrons with a boron-10 core that produces alpha particles and lithium nuclei. The result of this boron reaction has high linear energy transfer (LET). BNCT has an advantage over other radiation therapy in that it has a high selectivity level. This research was run using PHITS simulation to find out the value of neutron flux spread over a water phantom. The conclusion of the research is the distribution of neutron flux in the water phantom without boron is higher the the distribution of neutron flux in the water phantom containing boron
Immunohistochemical Detection of Vasa Antigen and Apoptosis-Related DNA Fragmentation in Ovaries of Sheep Fetuses Prenatally Exposed to Vitamin D Deficiency
Authors: Mbegbu Edmund C. , Obidike Ikechukwu R. , Fouladi-Nashta Ali A. 
Published: September 2019

Abstract
The primordial germ cells (PGCs) in female animals are comprised of diplotene oocytes arrested in the first meiotic prophase. Expression of Vasa is one of the key factors required for subsequent resumption of development and recruitment of PGCs into the growing follicle class. Since vitamin D regulates recruitment of PGCs and developmental competence of ovarian follicles, this study was designed to investigate the expression of Vasa and rate of apoptosis in foetal ovaries prenatally restricted from dietary vitamin D. Nineteen sexually mature Welsh mountain ewes were randomly assigned to vitamin D deficient (VDD) and vitamin D control (VDC) diets from 17d before mating, up to 125d of gestation, when fetal ovaries were collected and fixed in formalin for immunohistochemistry and TUNEL assay. VDD ovaries had fewer healthy oocytes that could stain positive for Vasa as well as a lower integrated density value for DAB staining intensity. Conversely, TUNNEL staining in VDD animals showed a higher integrated density value and percentage of affected area (P<0.05). The present findings indicate that Vasa expression is decreased, while the rate of apoptosis increased in VDD fetal ovaries, and this may adversely affect resumption of growth and development of PGCs reserve.
Clinical and Radiological Evaluation of the Treatment of Cranial Cruciate Ligament Rupture in Cats with the Musculus Biceps Femoris Transposition Technique
Authors: Şen İlker 
Published: September 2019

Abstract
The aim of this study was to clinically and radiologically evaluate the technique of biceps femoris muscle transposition as a new extracapsular treatment technique for cranial cruciate ligament ruptures, which are often encountered in cats. In this study, eight cats diagnosed with cranial cruciate ligament rupture were treated with the biceps femoris muscle transposition technique. The postoperative standard clinical examination procedures were applied to each cat for 90 days. In the preoperative clinical and radiological examinations of the eight cats in the study, cranial cruciate ligament rupture alone was diagnosed in seven of them. Both, the cranial cruciate ligament rupture and meniscal lesions in the same stifle joint were determined in one cat. The biceps femoris muscle transposition technique operation took approximately 20 mins in each case.
The postoperative radiographs were taken on days 10, 30, 60 and 90. No complications were seen in any case during the postoperative follow-up. The Illinois University Evaluation Scale was used for a more objective evaluation. At 90 days postoperatively, there was no lameness in seven out of eight cats, and mild limping was determined in one of them due to concomitant meniscal lesion.
According to the study results, the biceps femoris muscle transposition technique was found to be extremely useful as an easily applicable technique in the treatment of cranial cruciate ligament rupture in cats.
Comparative Study of Needle Penetration Forces in Sewing Hems on Toweling Terry Fabrics: Influence of Needle Type and Size
Authors: Carvalho Manuel , Rocha Ana Maria , Carvalho Helder 
Published: September 2019

AbstractIn this paper, an industrial case study comparing the use of different needles in the production of hems in towels is presented. The study aims to assess the sewability of the fabrics, quantified by needle penetration forces. The market offers an interesting range of options for the needle, regarding the geometry of the needle point, surface finishing, and sizes. However, in practice, the choice is difficult, namely due to the lack of quantitative data that may support the empirical evaluation made by the sewing technicians. The work aims to assess how the needle type and size relate to the resulting needle penetration forces. Three terry fabric structures, produced by a home textiles manufacturer, were tested using needles of different sizes, points, and coatings. Needle penetration forces were measured on a sewability tester prototype, previously designed and developed, based on an instrumented overedge sewing machine. It was found that needle penetration forces present very significant differences with small size increments, needle coating also influences forces significantly, and different needle points produce only slight differences, significant only on some of the fabrics that were tested.
Verbalization of Main Spectral Colors in Texts of Ukrainian Charms
Authors: Shuliak S. , Bezliudnyi O. , Koval V. , Masliuk K. 
Published: September 2019

Abstract
The purpose of this article is to study the verbalization of the main spectral colors in the texts of Ukrainian charms. In order to achieve the goal, the following tasks must be realized: 1- To determine the emotional and estimated semantics of red, blue, green, yellow colors and the function performed by the above-mentioned color titles to ensure pragmatics of charms. 2- To find out the direct and associative values of the main spectral colors in the texts of Ukrainian charms. 3- To discover the most common morphological category of color titles. It is established that the titles of the main spectral colors in the charming texts are usually filled with positive emotional-estimated semantics, but sometimes they are able to acquire other semantic shades of contradictory significance. As a result, the adjective is defined as the most common morphological category of color titles. The direct and associative values of the main spectral colors in the texts of Ukrainian charms are found. In conclusion, the color epithets of red, blue, green, yellow are capable of performing an emotional and expressive function, which contribute to the pragmatic effect of charms.
Alienation and Character Typology in African American and Native American Narratives: A Jungian Reading of The Bluest Eye and Winter in the Blood
Authors: Garuba Issa Omotosho 
Published: September 2019

Abstract
Alienation is a recurring literary subject in the United States. Its peculiarity is occasioned by the phenomenon of racial segregation, among others, with which the society is characterized. Thus, considerable critical attention has been given to the causes as well as the attendant socio-political, economic and psychological imports on the victims. From a psychological perspective, specifically, this paper engages in a comparative analysis of the effects of alienation on characters of African American and Native American origins produced by the same system in two novels which have African American and Native American roots – Toni Morrison’s The Bluest Eye and James Welch’s Winter in the Blood, respectively. In order to understand the variance and/or convergence in the personality formations of the African American and Native American characters in the narratives, consequent upon the racially alienating system, the paper adopts Carl Jung’s psychological theory of personality typology, labelled introversion and extraversion, with a view to assessing how, typically, persons of these origins are more likely to react to the socio-political, cultural and economic situations affecting them as minority ethnic groups in the United States.
KRAS, NRAS, BRAF, HER2 and microsatellite instability in metastatic colorectal cancer – practical implications for the clinician
Authors: Afrăsânie Vlad-Adrian , Marinca Mihai Vasile , Alexa-Stratulat Teodora , Gafton Bogdan , Păduraru Marius , Adavidoaiei Anca Maria , Miron Lucian , Rusu Cristina 
Published: September 2019

Abstract

Background
Colorectal cancer is a successful model of genetic biomarker development in oncology. Currently, several predictive or prognostic genetic alterations have been identified and are used in clinical practice. The RAS gene family, which includes KRAS and NRAS act as predictors for anti-epithelial growth factor receptor treatment (anti-EGFR), and it has been suggested that NRAS mutations also play a role in prognosis: patients harboring NRAS alterations have a significantly shorter survival compared to those with wild type tumours. BRAF V600E mutations are rare and occur mostly in tumors located in the ascending colon in elderly female patients. BRAF is instrumental in establishing prognosis: survival is shorter by 10–16 months in BRAF-mutant patients, and BRAF may be a negative prognostic factor for patients who undergo hepatic or pulmonary metastasectomy. Moreover, this mutation is used as a negative predictive factor for anti-EGFR therapies. Two new biomarkers have recently been added to the metastatic colorectal cancer panel: HER2 and microsatellite instability. While HER2 is still being investigated in different prospective studies in order to validate its prognostic role, microsatellite instability already guides clinical decisions in substituted with advanced colorectal cancer.

Conclusions
There are current evidences that support using above mentioned genetic biomarkers to better identify the right medicine that is supposed to be used in the right patient. This approach contributes to a more individualized patient-oriented treatment in daily clinical practice.
Factors affecting the morbidity and mortality of diverting stoma closure: retrospective cohort analysis of twelve-year period
Authors: Krebs Bojan , Ivanecz Arpad , Potrc Stojan , Horvat Matjaz 
Published: September 2019

Abstract

Background
Diverting stoma is often performed in rectal cancer surgery for reducing the consequences of possible anastomotic failure. Closing of stoma follows in most cases after a few months. The aim of our study was to evaluate morbidity and mortality after diverting stoma closure and to identify risk factors for complications of this procedure.

Patients and methods
At our department, we have performed a retrospective cohort analysis of data for 260 patients with diverting stoma closure from 2003 to 2015. Age, stoma type, patient’s preoperative ASA score, surgical technique and time to stoma closure were investigated as factors which could influence the complication rate.

Results
218 patients were eligible for investigation. Postoperative complications developed in 54 patients (24.8%). Most common complications were postoperative ileus (10%) and wound infection (5%). Four patients died (1.8%). There was no effect on complication rate regarding type of stoma, closing technique, patient’s ASA status and patient age. The only factor influencing the complication rate was the time to stoma closure. We found that patients which had the stoma closed prior to 8 months after primary surgery had lower overall complication rate (p<0. 05).

Conclusions
To reduce overall complication rate, our data suggest a shorter period than 8 months after primary surgery before closure of diverting stoma. As diverting stoma closure is not a simple operation, all strategies should be taken to reduce significant morbidity and mortality rate.
Impact of Concentrate Level and Stage of Lactation on Fatty Acid Composition in Goat Milk
Authors: Novotná K. , Ptáček M. , Fantová M. , Nohejlová L. , Stádník L. , Okrouhlá M. , Peták Z. 
Published: September 2019

Abstract
The impact of different amounts of concentrate and stage of lactation on fatty acid profile in milk fat was measured in 30 lactating Nubian goats. The ration included medium-quality hay, grazed pasture and concentrate feed (mashed barley, oats and beet pulp at 1:1:1 wet weight ratios). Half of the goats (group A) received 1.2 kg whereas group B received 1.0 kg of concentrate daily. Milk samples were taken 3 times during lactation. The total amounts of saturated fatty acids (SFA) increased gradually during lactation while polyunsaturated (PUFA) and monounsaturated fatty acids (MUFA) decreased. Group A had lower SFA but higher concentrations of MUFAs and PUFAs at all 3 samplings. Nubian goats fed more concentrate had FA ratios presumably more suitable for consumers of milk and milk products.