bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Timely Prenatal Care Initiation and Adequate Utilization in a Sample of Late Adolescent Texas Latinas
Authors: Torres Rosamar , Kehoe Priscilla , Heilemann MarySue V. 
Published: April 2018

Introduction: Little is known of late adolescent Texas Latinas’ prenatal care perceptions or how these perceptions predict timely prenatal care initiation or adequate utilization. Hence, the purpose of this study is to describe and compare these perceptions between participants with timely versus late prenatal care initiation and adequate, intermediate, and inadequate prenatal care utilization; and to determine predictors of timely prenatal care initiation and adequate utilization. Methods: Fifty-four postpartum Latinas were recruited through social media. Eligibility criteria were 18 to 21 years old, Texas-born, primiparous, uncomplicated pregnancy/delivery, and English literate. Prenatal care perceptions were measured with the Revised Better Babies Survey and Access Barriers to Care Index. Results: Participants had favorable views of prenatal care benefits; however, not living with the baby’s father predicted inadequate prenatal care, Wald χ2(1) = 4.93, p = .026. Perceived benefits of timely and adequate prenatal care predicted timely prenatal care initiation, χ2(1) = 7.47, p = .006. Self-reported depression during pregnancy predicted timely entry into prenatal care, χ2(1) = 4.73, p = .03. Conclusion: Participants’ positive prenatal care perceptions did not predict adequate prenatal care utilization, indicating that barriers serve as powerful obstacles in late adolescent Texas Latinas.
Cancer Storytelling: A Study of Well-Being Expressions Made by Patients
Authors: Brown Gregory , de Jong Jim (J.W.) 
Published: April 2018

Many cancer patients tell their story to help others. This paper reports a study of 160 such stories, which were processed using a grounded theory methodology. The stories were rich in emotional words and in metaphors and these, along with self-talk and meaning-for-life, provided the commonest indications of the patients’ well-being. Cancer patients, through the process of telling their story, help themselves and enhance their well-being. The method of active listening is described, with associated risks for professionals.
Two Novel MicroRNA Biomarkers Related to β-Cell Damage and Their Potential Values for Early Diagnosis of Type 1 Diabetes
Authors: Liu Li , Yan Jinhua , Xu Haixia , Zhu Yunxia , Liang Hua , Pan Wen , Yao Bin , Han Xiao , Ye Jianping , Weng Jianping 
Published: April 2018

Abstract

Context
New strategies and biomarkers are needed in the early detection of β-cell damage in the progress of type 1 diabetes mellitus (T1DM).

Objective
To explore whether serum microRNAs (miRNA) should be served as biomarkers for T1DM.

Design, Settings, and Patients
The miRNA profile was established with miRNA microarray in discovery phase (six T1DM, six controls). A miRNA-based model for T1DM diagnosis was developed using logistic regression analysis in the training dataset (40 T1DM, 56 controls) and then validated with leave-one-out cross validation and another independent validation dataset (33 T1DM, 29 controls).

Main Outcome Measures
Quantitative reverse transcription polymerase chain reaction was applied to confirm the differences of candidate miRNAs between T1DM and controls. Area under the receiver-operating characteristic (ROC) curve (AUC) was used to evaluate diagnostic accuracy. INS-1 cells, streptozotocin-treated mice (n = 4), and nonobese diabetic (NOD) mice (n = 12) were used to evaluate the association of miRNAs with β-cell damage.

Results
A miRNA -based model was established in the training dataset with high diagnostic accuracy for T1DM (AUC = 0.817) based on six candidate differential expressed miRNAs identified in discovery phase. The validation dataset showed the model’s satisfactory diagnostic performance (AUC = 0.804). Secretions of miR-1225-5p and miR-320c were significantly increased in streptozotocin-treated mice and INS-1 cells. Noteworthy, the elevation of these two miRNAs was observed before glucose elevation in the progress of diabetes in NOD mice.

Conclusions
Two miRNA biomarkers (miR-1225-5p and miR-320c) related to β-cell damage were identified in patients with recent-onset T1DM. The miRNA-based model established in this study exhibited a good performance in diagnosis of T1DM.
Homeostasis Model Assessment of Insulin Resistance and Survival in Patients With Diabetes and Acute Coronary Syndrome
Authors: Stähli Barbara E , Nozza Anna , Schrieks Ilse C , Buse John B , Malmberg Klas , Mellbin Linda , Neal Bruce , Nicholls Stephen J , Rydén Lars , Svensson Anders , Wedel Hans , Weichert Arlette , Lincoff A Michael , Grobbee Diederick E , Tardif Jean-Claude , Schwartz Gregory G 
Published: April 2018

Abstract

Objective
Insulin resistance has been linked to development and progression of atherosclerosis and is present in most patients with type 2 diabetes. Whether the degree of insulin resistance predicts adverse outcomes in patients with type 2 diabetes and acute coronary syndrome (ACS) is uncertain.

Design
The Effect of Aleglitazar on Cardiovascular Outcomes after Acute Coronary Syndrome in Patients with Type 2 Diabetes Mellitus trial compared the peroxisome proliferator-activated receptor-α/γ agonist aleglitazar with placebo in patients with type 2 diabetes and recent ACS. In participants not treated with insulin, we determined whether baseline homeostasis model assessment of insulin resistance (HOMA-IR; n = 4303) or the change in HOMA-IR on assigned study treatment (n = 3568) was related to the risk of death or major adverse cardiovascular events (cardiovascular death, myocardial infarction, and stroke) in unadjusted and adjusted models. Because an inverse association of HOMA-IR with N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been described, we specifically examined effects of adjustment for the latter.

Results
In unadjusted analysis, twofold higher baseline HOMA-IR was associated with lower risk of death [hazard ratio (HR): 0.79, 95% CI: 0.68 to 0.91, P = 0.002]. Adjustment for 24 standard demographic and clinical variables had minimal effect on this association. However, after further adjustment for NT-proBNP, the association of HOMA-IR with death was no longer present (adjusted HR: 0.99, 95% CI: 0.83 to 1.19, P = 0.94). Baseline HOMA-IR was not associated with major adverse cardiovascular events, nor was the change in HOMA-IR on study treatment associated with death or major adverse cardiovascular events.

Conclusions
After accounting for levels of NT-proBNP, insulin resistance assessed by HOMA-IR is not related to the risk of death or major adverse cardiovascular events in patients with type 2 diabetes and ACS.
Archiveology
Authors: Russell Catherine 
Published: April 2018

In Archiveology Catherine Russell uses the work of Walter Benjamin to explore how the practice of archiveology—the reuse, recycling, appropriation, and borrowing of archival sounds and images by filmmakers—provides ways to imagine the past and the future. Noting how the film archive does not function simply as a place where moving images are preserved, Russell examines a range of films alongside Benjamin's conceptions of memory, document, excavation, and historiography. She shows how city films such as Nicole Védrès's Paris 1900 (1947) and Thom Andersen's Los Angeles Plays Itself (2003) reconstruct notions of urban life and uses Christian Marclay's The Clock (2010) to draw parallels between critical cinephilia and Benjamin's theory of the phantasmagoria. Russell also discusses practices of collecting in archiveological film and rereads films by Joseph Cornell and Rania Stephan to explore an archival practice that dislocates and relocates the female image in film. In so doing, she not only shows how Benjamin's work is as relevant to film theory as ever; she shows how archiveology can awaken artists and audiences to critical forms of history and memory.
Dust of the Zulu
Authors: Meintjes Louise 
Published: April 2018

In Dust of the Zulu Louise Meintjes traces the political and aesthetic significance of ngoma, a competitive form of dance and music that emerged out of the legacies of colonialism and apartheid in South Africa. Contextualizing ngoma within South Africa's history of violence, migrant labor, the HIV epidemic, and the world music market, Meintjes follows a community ngoma team and its professional subgroup during the twenty years after apartheid's end. She intricately ties aesthetics to politics, embodiment to the voice, and masculine anger to eloquence and virtuosity, relating the visceral experience of ngoma performances as they embody the expanse of South African history. Meintjes also shows how ngoma helps build community, cultivate responsible manhood, and provide its participants with a means to reconcile South Africa's past with its postapartheid future. Dust of the Zulu includes over one hundred photographs of ngoma performances, the majority taken by award-winning photojournalist TJ Lemon.
Phosphorylation hotspot in the C-terminal domain of occludin regulates the dynamics of epithelial junctional complexes
Authors: Manda Bhargavi , Mir Hina , Gangwar Ruchika , Meena Avtar S. , Amin Shrunali , Shukla Pradeep K. , Dalal Kesha , Suzuki Takuya , Rao RadhaKrishna 
Published: April 2018

ABSTRACT
The apical junctional complex (AJC), which includes tight junctions (TJs) and adherens junctions (AJs), determines the epithelial polarity, cell-cell adhesion and permeability barrier. An intriguing characteristic of a TJ is the dynamic nature of its multiprotein complex. Occludin is the most mobile TJ protein, but its significance in TJ dynamics is poorly understood. On the basis of phosphorylation sites, we distinguished a sequence in the C-terminal domain of occludin as a regulatory motif (ORM). Deletion of ORM and expression of a deletion mutant of occludin in renal and intestinal epithelia reduced the mobility of occludin at the TJs. ORM deletion attenuated Ca2+ depletion, osmotic stress and hydrogen peroxide-induced disruption of TJs, AJs and the cytoskeleton. The double point mutations T403A/T404A, but not T403D/T404D, in occludin mimicked the effects of ORM deletion on occludin mobility and AJC disruption by Ca2+ depletion. Both Y398A/Y402A and Y398D/Y402D double point mutations partially blocked AJC disruption. Expression of a deletion mutant of occludin attenuated collective cell migration in the renal and intestinal epithelia. Overall, this study reveals the role of ORM and its phosphorylation in occludin mobility, AJC dynamics and epithelial cell migration.
The Arf-GDP-regulated recruitment of GBF1 to Golgi membranes requires domains HDS1 and HDS2 and a Golgi-localized protein receptor
Authors: Quilty Douglas , Chan Calvin J. , Yurkiw Katherine , Bain Alexandra , Babolmorad Ghazal , Melançon Paul 
Published: April 2018

ABSTRACT
We previously proposed a novel mechanism by which the enzyme Golgi-specific Brefeldin A resistance factor 1 (GBF1) is recruited to the membranes of the cis-Golgi, based on in vivo experiments. Here, we extended our in vivo analysis on the production of regulatory Arf-GDP and observed that ArfGAP2 and ArfGAP3 do not play a role in GBF1 recruitment. We confirm that Arf-GDP localization is critical, as a TGN-localized Arf-GDP mutant protein fails to promote GBF1 recruitment. We also reported the establishment of an in vitro GBF1 recruitment assay that supports the regulation of GBF1 recruitment by Arf-GDP. This in vitro assay yielded further evidence for the requirement of a Golgi-localized protein because heat denaturation or protease treatment of Golgi membranes abrogated GBF1 recruitment. Finally, combined in vivo and in vitro measurements indicated that the recruitment to Golgi membranes via a putative receptor requires only the HDS1 and HDS2 domains in the C-terminal half of GBF1.
The enhancement in comprehension for the younger generation of school age in conserving coastal biodiversity in Kepulauan Seribu, Indonesia
Authors: HANDAYANI TUTY , WIDIARTI RIANI , SOEPARDJO A. HARSONO , ARIYANI FIKA , BURHANUDDIN EKO 
Published: April 2018

Handayani T, Widiarti R, Soepardjo AH, Afriyani F, Burhanuddin E. 2017. The enhancement in comprehension for the younger generation of school age in conserving coastal biodiversity in Kepulauan Seribu, Indonesia. Ocean Life 1: 20-25. The exploration and exploitation can lead to the ecosystem and natural resources degradation. Kepulauan Seribu of Special Area of Jakarta has been extensively utilized and developed for tourism area, which could lead to the decreasing of environmental conditions. The awareness for keeping the ecosystem and marine life should be developed since early age. The objective of this research is to determine the level of understanding and ability in conserving the marine environment in their neighborhood for school-age generation. The method used in this study was quantitative with descriptive analysis. Two groups of the Junior High School students of Pulau Tidung and Pulau Harapan of the Kepulauan Seribu were provided training on conservation on coastal ecosystems. The education and training encompass the observation activity for coral reef using the Coral Health Chart method, seagrass condition observation through SeagrassWatch method, and introduction in the mangrove ecosystem. Based on the study, it can be inferred that the resulting activity indicated the level of understanding of cognitive abilities of two groups of the Junior High School in those two locations has increased. In addition, they affective ability increased sharply toward the students from Pulau Tidung whereas in Pulau Harapan an occurred a large increase in psychomotor abilities. The conclusion of this program is managed to improve the understanding and ability to act for the younger generation in conserving marine and coastal environments.
Graphs and metric 2-step nilpotent Lie algebras
Authors: DeCoste Rachelle C. , DeMeyer Lisa , Mainkar Meera G. 
Published: April 2018

Abstract
Dani and Mainkar introduced a method for constructing a 2-step nilpotent Lie algebra 𝔫
G
from a simple directed graph G in 2005. There is a natural inner product on 𝔫
G
arising from the construction. We study geometric properties of the associated simply connected 2-step nilpotent Lie group N with Lie algebra 𝔫
g
. We classify singularity properties of the Lie algebra 𝔫
g
in terms of the graph G. A comprehensive description is given of graphs G which give rise to Heisenberg-like Lie algebras. Conditions are given on the graph G and on a lattice Γ ⊆ N for which the quotient Γ \ N, a compact nilmanifold, has a dense set of smoothly closed geodesics. This paper provides the first investigation connecting graph theory, 2-step nilpotent Lie algebras, and the density of closed geodesics property.
Assessment of variance & distribution in data for effective use of statistical methods for product quality prediction
Authors: Weiß Iris , Vogel-Heuser Birgit 
Published: April 2018

Abstract
Data mining in automated production systems provide high potential to increase the Overall Equipment Effectiveness. Nevertheless, data of such machines/plants include specific characteristics regarding the variance and distribution of the dataset. For modelling product quality prediction, these characteristics have to be analysed to interpret the results correctly. Therefore, an approach for the analysis of variance and distribution of datasets is proposed. The evaluation of this approach validates the developed guidelines, which identify the reasons for inconsistent prediction results based on two different datasets of the same production system.
Interpretable machine learning with reject option
Authors: Brinkrolf Johannes , Hammer Barbara 
Published: April 2018

Abstract
Classification by means of machine learning models constitutes one relevant technology in process automation and predictive maintenance. However, common techniques such as deep networks or random forests suffer from their black box characteristics and possible adversarial examples. In this contribution, we give an overview about a popular alternative technology from machine learning, namely modern variants of learning vector quantization, which, due to their combined discriminative and generative nature, incorporate interpretability and the possibility of explicit reject options for irregular samples. We give an explicit bound on minimum changes required for a change of the classification in case of LVQ networks with reject option, and we demonstrate the efficiency of reject options in two examples.
Simulation and optimization of industrial production lines
Authors: Longo Claudio Santo , Fantuzzi Cesare 
Published: April 2018

Abstract
Simulation and optimization techniques are the pillars of for the Virtual Commissioning of modern digital factories. In particular, industrial production lines are complex systems formed by a set of machines that have several cross-dependencies (i. e., the production efficiency of a machine impact deeply performance figures of the others and affects the whole line productivity). The simulation and optimization of production lines is an integrated approach that allows finding efficiently optimized production parameters. This paper presents an example of application of the simulation to the virtual design and optimization of an industrial production line.
Homocysteine is the confounding factor of metabolic syndrome-confirmed by siMS score
Authors: Srećković Branko , Soldatovic Ivan , Colak Emina , Mrdovic Igor , Sumarac-Dumanovic Mirjana , Janeski Hristina , Janeski Nenad , Gacic Jasna , Dimitrijevic-Sreckovic Vesna 
Published: April 2018

Abstract

Background:
Abdominal adiposity has a central role in developing insulin resistance (IR) by releasing pro-inflammatory cytokines. Patients with metabolic syndrome (MS) have higher values of homocysteine. Hyperhomocysteinemia correlates with IR, increasing the oxidative stress. Oxidative stress causes endothelial dysfunction, hypertension and atherosclerosis. The objective of the study was to examine the correlation of homocysteine with siMS score and siMS risk score and with other MS co-founding factors.

Methods:
The study included 69 obese individuals (age over 30, body mass index [BMI] >25 kg/m2), classified into two groups: I-with MS (33 patients); II-without MS (36 patients). Measurements included: anthropometric parameters, lipids, glucose regulation parameters and inflammation parameters. IR was determined by homeostatic model assessment for insulin resistance (HOMA-IR). ATP III classification was applied for diagnosing MS. SiMS score was used as continuous measure of metabolic syndrome.

Results:
A significant difference between groups was found for C-reactive protein (CRP) (p<0.01) apolipoprotein (Apo) B, HOMA-IR and acidum uricum (p<0.05). siMS risk score showed a positive correlation with homocysteine (p=0.023), while siMS score correlated positively with fibrinogen (p=0.013), CRP and acidum uricum (p=0.000) and homocysteine (p=0.08). Homocysteine correlated positively with ApoB (p=0.036), HbA1c (p=0.047), HOMA-IR (p=0.008) and negatively with ApoE (p=0.042).

Conclusions:
Correlation of siMS score with homocysteine, fibrinogen, CRP and acidum uricum indicates that they are co-founding factors of MS. siMS risk score correlation with homocysteine indicates that hyperhomocysteinemia increases with age. Hyperhomocysteinemia is linked with genetic factors and family nutritional scheme, increasing the risk for atherosclerosis.
Templet Web: the use of volunteer computing approach in PaaS-style cloud
Authors: Vostokin Sergei , Artamonov Yuriy , Tsarev Daniil 
Published: April 2018

Abstract
This article presents the Templet Web cloud service. The service is designed for high-performance scientific computing automation. The use of high-performance technology is specifically required by new fields of computational science such as data mining, artificial intelligence, machine learning, and others. Cloud technologies provide a significant cost reduction for high-performance scientific applications. The main objectives to achieve this cost reduction in the Templet Web service design are: (a) the implementation of “on-demand” access; (b) source code deployment management; (c) high-performance computing programs development automation. The distinctive feature of the service is the approach mainly used in the field of volunteer computing, when a person who has access to a computer system delegates his access rights to the requesting user. We developed an access procedure, algorithms, and software for utilization of free computational resources of the academic cluster system in line with the methods of volunteer computing. The Templet Web service has been in operation for five years. It has been successfully used for conducting laboratory workshops and solving research problems, some of which are considered in this article. The article also provides an overview of research directions related to service development.
Twenty-seven mutations with three novel pathologenic variants causing biotinidase deficiency: a report of 203 patients from the southeastern part of Turkey
Authors: Seker Yilmaz Berna , Mungan Neslihan Onenli , Kor Deniz , Bulut Derya , Seydaoglu Gülşah , Öktem Murat , Ceylaner Serdar 
Published: April 2018

Abstract

Background:
Biotinidase deficiency (BD) is an autosomal recessive inborn error of metabolism characterized by neurologic and cutaneous symptoms and can be detected by newborn screening. Newborn screening for BD was implemented in Turkey at the end of 2008.

Methods:
In total, 203 patients who were identified among the infants detected by the newborn screening were later confirmed to have BD through measurement of serum biotinidase activity. We also performed BTD mutation analysis to characterize the genetic profile.

Results:
Twenty-seven mutations were identified. The most commonly found variants were c.1330G>C (p.D444H), c.1595C>T (p.T532M), c.470G>A (p.R157H), and c.198_104delGCGGCTGinsTCC (p.C33Ffs ) with allele frequencies of 0.387, 0.175, 0.165 and 0.049, respectively. Three novel pathogenic and likely pathogenic variants were identified: p.W140* (c.419G>A), p.S319F (c.956C>T) and p.L69Hfs*24 (c.192_193insCATC). We also identified three mutations reported in just one patient in the past (p.V442Sfs*59 [c.1324delG], p.H447R [c.1340A>G] and p.198delV [c.592_594delGTC]). Although all of the patients were asymptomatic under the treatment of biotin, only one patient, who had the novel c.419G>A homozygous mutation became symptomatic during an episode of acute gastroenteritis with a presentation of ketosis and metabolic acidosis. Among the screened patients, 156 had partial and 47 had profound BD.

Conclusions:
We determined the mutation spectra of BD from the southeastern part of Turkey. The results of this study add three more mutations to the total number of mutations described as causing BD.