bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruhedukasi Hipertensi Dengan Media Booklet Terhadap Perilaku Self Management Pada Pasien Hipertensi Di Wilayah Puskesmas Balowerti Kediri
Authors: Wahyuni Sri 
Published: November 2018

Background :Hypertension is a disease which can damage the organ progressively and settled, disease caused diseases such as stroke, cardiovascular disorders, kidney failure, and other serious diseases that threaten a person's life. Self management can be applied to patients with hypertension in an effort to enhancing the knowledge, attitudes and behavior.Objective :This research aims to the influence of education booklets media to self management in patients hypertension in the Puskesmas Balowerti Kota Kediri. Methods :This type of research is quantitative, with pre-post test design in one group (one-group pre-post test design). The sample in this study were 30 respondents selected by accidental sampling.Results: based on the obtained paired T test p-value is 0.000 ;α = 0.05. Conclusions and recommendations :There is a significant effect of hypertension with the media giving education booklet on self management behaviors in patients with hypertension in the PuskesmasBalowerti Kediri. To improve the behavior of self-management in hypertensive patients can consider the provision of structured edukas use media interest, so that more effective education.
Does Misalignment between Magnetic Field and Angular Momentum Enhance or Suppress Circumstellar Disk Formation?
Authors: Tsukamoto Y. , Okuzumi S. , Iwasaki K. , Machida M. N. , Inutsuka S. 
Published: November 2018

Abstract
The effect of misalignment between the magnetic field

and the angular momentum

of molecular cloud cores on the angular momentum evolution during the gravitational collapse is investigated by ideal and non-ideal MHD simulations. For the non-ideal effect, we consider the ohmic and ambipolar diffusion. Previous studies that considered the misalignment reported qualitatively contradicting results. Magnetic braking was reported as being either strengthened or weakened by misalignment in different studies. We conducted simulations of cloud core collapse by varying the stability parameter α (the ratio of the thermal to gravitational energy of the core) with and without including magnetic diffusion. The non-ideal MHD simulations show the central angular momentum of the core, with θ = 0° (

) being always greater than that with θ = 90° (

), independently of α, meaning that circumstellar disks form more easily in a core with θ = 0°. The ideal MHD simulations, in contrast, show the central angular momentum of the core with θ = 90° being greater than with θ = 0° for small α and smaller for large α. Inspection of the angular momentum evolution of the fluid elements reveals three mechanisms contributing to the evolution of the angular momentum: (i) magnetic braking in the isothermal collapse phase, (ii) selective accretion of the rapidly (for θ = 90°) or slowly (for θ = 0°) rotating fluid elements to the central region, and (iii) magnetic braking in the first core and the disk. The difference between the ideal and non-ideal simulations arises from the different efficiencies of (iii).
The H0 Tension in Non-flat QCDM Cosmology
Authors: Miao Haitao , Huang Zhiqi 
Published: November 2018

Abstract
The recent local measurement of the Hubble constant leads to a more than 3σ tension with Planck + ΛCDM. In this article we study the H
0 tension in non-flat QCDM cosmology, where Q stands for a minimally coupled and slowly or moderately rolling quintessence field ϕ with a smooth potential

, and CDM refers to cold dark matter. By generalizing the QCDM one-parameter and three-parameter parameterizations in Huang et al. to a non-flat universe and using the latest cosmological data, we find that the H
0 tension remains above the 3.2σ level for this class of model.
Super-Eddington Accretion in the WISE-selected Extremely Luminous Infrared Galaxy W2246−0526
Authors: Tsai Chao-Wei , Eisenhardt Peter R. M. , Jun Hyunsung D. , Wu Jingwen , Assef Roberto J. , Blain Andrew W. , Díaz-Santos Tanio , Jones Suzy F. , Stern Daniel , Wright Edward L. , Yeh Sherry C. C. 
Published: November 2018

Abstract
We use optical and near-infrared spectroscopy to observe rest-UV emission lines and estimate the black hole mass of WISEA J224607.56−052634.9 (W2246−0526) at z = 4.601, the most luminous hot, dust-obscured galaxy yet discovered by WISE. From the broad component of the Mg ii 2799 Å emission line, we measure a black hole mass of log(M
BH/M
☉) = 9.6 ± 0.4. The broad C iv 1549 Å line is asymmetric and significantly blueshifted. The derived M
BH from the blueshift-corrected broad C iv line width agrees with the Mg ii result. From direct measurement using a well-sampled SED, the bolometric luminosity is 3.6 × 1014
L
☉. The corresponding Eddington ratio for W2246−0526 is λ
Edd = L
AGN/L
Edd = 2.8. This high Eddington ratio may reach the level where the luminosity is saturating due to photon trapping in the accretion flow and may be insensitive to the mass accretion rate. In this case, the M
BH growth rate in W2246−0526 would exceed the apparent accretion rate derived from the observed luminosity.
Bipolar Ionization Cones in the Extended Narrow-line Region of Nearby QSO2s
Authors: Storchi-Bergmann T. , Dall’Agnol de Oliveira B. , Micchi L. F. Longo , Schmitt H. R. , Fischer T. C. , Kraemer S. , Crenshaw M. , Maksym P. , Elvis M. , Fabbiano G. , Colina L. 
Published: November 2018

Abstract
We have used narrowband [O iii] λλ4959, 5007 and Hα+[N ii] λλ6548, 84 Hubble Space Telescope (HST) images of nine luminous (L[O iii] > 1042 erg s−1) type 2 QSOs with redshifts 0.1 < z < 0.5 in order to constrain the geometry of their extended narrow-line regions (ENLRs), as recent ground-based studies suggest that these regions become more spherical at high luminosities due to destruction of the torus. We instead find elongated ENLRs reaching 4–19 kpc from the nucleus and bipolar ionization cones in [O iii]/(Hα+[N ii]) excitation maps indicating that the torus survives these luminosities, allowing the escape of ≈10 times higher ionizing photon rates along the ionization axis than perpendicular to it. The exceptional HST angular resolution was key to our success in arriving at these conclusions. Combining our measurements with previous ones based on similar HST data, we have revisited the relation between the ENLR radius R
maj and L[O iii] over the range 39 < log(L[O iii]) < 43.5 (L in erg s−1): log(R
maj) = (0.51 ± 0.03) log(L[O iii])−18.12 ± 0.98. The radius of the ENLR keeps increasing with L[O iii] in our data, implying that the ENLR can extend to distances beyond the limit of the galaxy if gas is present there—e.g., from active galactic nucleus (AGN) outflows or interactions, seen in six objects of our sample. We attribute the flattening previously seen in this relation to the fact that the ENLR is matter-bounded, meaning that ionizing photons usually escape to the intergalactic medium in luminous AGNs. Estimated ionized gas masses of the ENLRs range from 0.3 to 2 × 108
M
⊙, and estimated powers for associated outflows range from <0.1% to a few percent of the QSO luminosity.
A Concordance Picture of FRB 121102 as a Flaring Magnetar Embedded in a Magnetized Ion–Electron Wind Nebula
Authors: Margalit Ben , Metzger Brian D. 
Published: November 2018

Abstract
The fast radio burst FRB 121102 has repeated multiple times, enabling the identification of its host galaxy and of a spatially coincident, compact, steady (“persistent”) radio synchrotron source. It was proposed that FRB 121102 is powered by a young flaring magnetar, embedded within a decades-old supernova remnant. Using a time-dependent one-zone model, we show that a single expanding magnetized electron–ion nebula (created by the same outbursts likely responsible for the fast radio bursts) can explain all of the basic properties of the persistent source (size, flux, self-absorption constraints) and the large but decreasing rotation measure (RM) of the bursts. The persistent emission is powered by relativistic thermal electrons heated at the termination shock of the magnetar wind, while the RM originates from non-relativistic electrons injected earlier in the nebula’s evolution and cooled through expansion and radiative losses. The model contains few free parameters, which are tightly constrained by observations: the total energy injected into the nebula over its history, ∼1050−1051 erg, agrees with the magnetic energy of a millisecond magnetar; the baryon loading of the magnetar outflow (driven by intermittent flares) is close to the neutron star escape speed; the predicted source age ∼10–40 yr is consistent with other constraints on the nebula size. For an energy input rate

following the onset of magnetar activity, we predict secular decay of the RM and persistent source flux, which approximately follow RM ∝ t
−(6+α)/2 and

, respectively.
Age-Related Changes in Corneal Spherical Aberration
Authors: Kemraz Dhanishta , Cheng Xue-Ying , Shao Xu , Zhou Kai-Jing , Pan An-Peng , Lu Fan , Yu A-Yong 
Published: November 2018

PURPOSE:
To analyze the age-related changes in corneal spherical aberration (CSA) and higher order aberrations (HOAs) and to develop a novel model to estimate the change in CSA with age.

METHODS:
This was a cross-sectional study of the right eyes of 3,769 patients. Anterior corneal spherical aberration (ASA), posterior corneal spherical aberration (PSA), total corneal spherical aberration (TSA), and the root mean square of corneal HOAs were measured using a Scheimpflug tomographer. Smoothed fitting curves were plotted as a function of age and the average change in spherical aberration was calculated for different ages.

RESULTS:

The mean magnitude of ASA, PSA, TSA, and HOAs (6 and 4 mm) were 0.270 ± 0.111, −0.144 ± 0.031, 0.228 ± 0.120, 0.453 ± 0.194, and 0.141 ± 0.075
µ
m, respectively. All parameters showed a statistically significant non-linear change with age. The age after which the aberrations increased at a faster rate, namely the turning points of age, were 39 years for ASA, PSA, TSA, and 6-mm HOAs (95% confidence interval [CI]: 35 to 42, 36 to 41, 36 to 42, and 35 to 56 years, respectively) and 46 years for 4-mm HOAs (95% CI: 36 to 56 years). There were significant increases in increment rates after the turning points. The average change of TSA was −0.013
µ
m/10 years from 18 to 39 years and 0.057
µ
m/10 years after 39 years. There were statistically significant correlations between ASA and TSA (
r
= 0.976,
P
< .001) and PSA and TSA (
r
= 0.192,
P
< .001), but not between ASA and PSA (
r
= −0.003,
P
= .835).

CONCLUSIONS:
CSA and HOAs increased non-linearly with age and became more positive after 39 and 46 years of age, respectively. Based on the increment rates and turning points of age, a novel model is provided to help calculate the value required to compensate for the increasing CSA associated with the aging cornea.

[
J Refract Surg
. 2018;34(11):760–767.]
Indole-3-Pyruvic Acid, an Aryl Hydrocarbon Receptor Activator, Suppresses Experimental Colitis in Mice
Authors: Aoki Reiji , Aoki-Yoshida Ayako , Suzuki Chise , Takayama Yoshiharu 
Published: November 2018

Abstract
Aryl hydrocarbon receptor (AHR) agonists are promising immunomodulators that potentially maintain immune tolerance. In this study, we examined the ability of indole-3-pyruvic acid (IPA), a major precursor of microbiota-derived AHR agonists and a proagonist of AHR, to activate AHR. The anti-inflammatory effects of IPA were also evaluated in a mouse model of colitis in comparison with other aromatic pyruvic acids (phenylpyruvic acid and 4-hydroxyphenylpyruvic acid). Among them, IPA showed the strongest ability to activate AHR in vitro and in vivo, and only IPA improved chronic inflammation in an experimental colitis model. IPA attenuated the expression of genes encoding Th1 cytokines and enhanced Il-10 gene expression in the colon. Oral administration of IPA decreased the frequency of IFN-γ+ IL-10− CD4+ T cells and increased that of IFN-γ− IL-10+ CD4+ T cells in the colon lamina propria in a T cell–mediated colitis model. IPA directly promoted the differentiation of type 1 regulatory T cells in vitro. Furthermore, IPA administration attenuated the ability of dendritic cells (DCs) in the mesenteric lymph nodes (MLN) to induce IFN-γ–producing T cells, increased the frequency of CD103+ CD11b− DCs, and decreased the frequency of CD103− CD11b+ DCs in the MLN. Adoptive transfer of MLN CD103+ CD11b− DCs significantly improved the severity of colon inflammation. Treatment with an AHR antagonist inhibited IPA-induced differentiation of type 1 regulatory T cells and the IPA-induced increase in CD103+ CD11b− DCs and attenuated the anti-inflammatory effect of IPA. These findings suggest that IPA potently prevents chronic inflammation in the colon by activating AHR.
Predicting Humoral Alloimmunity from Differences in Donor and Recipient HLA Surface Electrostatic Potential
Authors: Mallon Dermot H. , Kling Christiane , Robb Matthew , Ellinghaus Eva , Bradley J. Andrew , Taylor Craig J. , Kabelitz Dieter , Kosmoliaptsis Vasilis 
Published: November 2018

Abstract
In transplantation, development of humoral alloimmunity against donor HLA is a major cause of organ transplant failure, but our ability to assess the immunological risk associated with a potential donor–recipient HLA combination is limited. We hypothesized that the capacity of donor HLA to induce a specific alloantibody response depends on their structural and physicochemical dissimilarity compared with recipient HLA. To test this hypothesis, we first developed a novel computational scoring system that enables quantitative assessment of surface electrostatic potential differences between donor and recipient HLA molecules at the tertiary structure level [three-dimensional electrostatic mismatch score (EMS-3D)]. We then examined humoral alloimmune responses in healthy females subjected to a standardized injection of donor lymphocytes from their male partner. This analysis showed a strong association between the EMS-3D of donor HLA and donor-specific alloantibody development; this relationship was strongest for HLA-DQ alloantigens. In the clinical transplantation setting, the immunogenic potential of HLA-DRB1 and -DQ mismatches expressed on donor kidneys, as assessed by their EMS-3D, was an independent predictor of development of donor-specific alloantibody after graft failure. Collectively, these findings demonstrate the translational potential of our approach to improve immunological risk assessment and to decrease the burden of humoral alloimmunity in organ transplantation.
Deregulated AUF1 Assists BMP-EZH2–Mediated Delayed Wound Healing during Candida albicans Infection
Authors: Mahadik Kasturi , Yadav Preeti , Bhatt Bharat , Shah Riyaz Ahmad , Balaji Kithiganahalli Narayanaswamy 
Published: November 2018

Abstract
Tissue repair is a complex process that necessitates an interplay of cellular processes, now known to be dictated by epigenetics. Intriguingly, macrophages are testimony to a large repertoire of evolving functions in this process. We identified a role for BMP signaling in regulating macrophage responses to Candida albicans infection during wound repair in a murine model. In this study, the RNA binding protein, AU-rich element–binding factor 1, was posttranslationally destabilized to bring about ubiquitin ligase, NEDD4-directed activation of BMP signaling. Concomitantly, PI3K/PKCδ mobilized the rapid phosphorylation of BMP-responsive Smad1/5/8. Activated BMP pathway orchestrated the elevated recruitment of EZH2 at promoters of genes assisting timely wound closure. In vivo, the repressive H3K27 trimethylation was observed to persist, accompanied by a robust upregulation of BMP pathway upon infection with C. albicans, culminating in delayed wound healing. Altogether, we uncovered the signaling networks coordinated by fungal colonies that are now increasingly associated with the infected wound microbiome, resulting in altered wound fate.
The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands
Authors: Gfeller David , Guillaume Philippe , Michaux Justine , Pak Hui-Song , Daniel Roy T. , Racle Julien , Coukos George , Bassani-Sternberg Michal 
Published: November 2018

Abstract
HLA-I molecules bind short peptides and present them for recognition by CD8+ T cells. The length of HLA-I ligands typically ranges from 8 to 12 aa, but variability is observed across different HLA-I alleles. In this study we collected recent in-depth HLA peptidomics data, including 12 newly generated HLA peptidomes (31,896 unique peptides) from human meningioma samples, to analyze the peptide length distribution and multiple specificity across 84 different HLA-I alleles. We observed a clear clustering of HLA-I alleles with distinct peptide length distributions, which enabled us to study the structural basis of peptide length distributions and predict peptide length distributions from HLA-I sequences. We further identified multiple specificity in several HLA-I molecules and validated these observations with binding assays. Explicitly modeling peptide length distribution and multiple specificity improved predictions of naturally presented HLA-I ligands, as demonstrated in an independent benchmarking based on the new human meningioma samples.
Complement Inhibitor CRIg/FH Ameliorates Renal Ischemia Reperfusion Injury via Activation of PI3K/AKT Signaling
Authors: Hu Chao , Li Long , Ding Peipei , Li Ling , Ge Xiaowen , Zheng Long , Wang Xuanchuan , Wang Jina , Zhang Weitao , Wang Na , Gu Hongyu , Zhong Fan , Xu Ming , Rong Ruiming , Zhu Tongyu , Hu Weiguo 
Published: November 2018

Abstract
Complement activation is involved in the pathogenesis of ischemia reperfusion injury (IRI), which is an inevitable process during kidney transplantation. Therefore, complement-targeted therapeutics hold great potential in protecting the allografts from IRI. We observed universal deposition of C3d and membrane attack complex in human renal allografts with delayed graft function or biopsy-proved rejection, which confirmed the involvement of complement in IRI. Using FB-, C3-, C4-, C5-, C5aR1-, C5aR2-, and C6-deficient mice, we found that all components, except C5aR2 deficiency, significantly alleviated renal IRI to varying degrees. These gene deficiencies reduced local (deposition of C3d and membrane attack complex) and systemic (serum levels of C3a and C5a) complement activation, attenuated pathological damage, suppressed apoptosis, and restored the levels of multiple local cytokines (e.g., reduced IL-1β, IL-9, and IL-12p40 and increased IL-4, IL-5, IL-10, and IL-13) in various gene-deficient mice, which resulted in the eventual recovery of renal function. In addition, we demonstrated that CRIg/FH, which is a targeted complement inhibitor for the classical and primarily alternative pathways, exerted a robust renoprotective effect that was comparable to gene deficiency using similar mechanisms. Further, we revealed that PI3K/AKT activation, predominantly in glomeruli that was remarkably inhibited by IRI, played an essential role in the CRIg/FH renoprotective effect. The specific PI3K antagonist duvelisib almost completely abrogated AKT phosphorylation, thus abolishing the renoprotective role of CRIg/FH. Our findings suggested that complement activation at multiple stages induced renal IRI, and CRIg/FH and/or PI3K/AKT agonists may hold the potential in ameliorating renal IRI.
A mortality review of tuberculosis and HIV co-infected patients in Mahalapye, Botswana: Does cotrimoxazole preventive therapy and/or antiretroviral therapy protect against death?
Authors: Tshitenge Stephane , Ogunbanjo Gboyega A. , Citeya Andre 
Published: November 2018

Background: The World Health Organization aims to reduce tuberculosis (TB) mortality rate from 15% in 2015 to 6.5% by 2025.Aim: This study determined the profile of TB and human immunodeficiency virus (HIV) co-infected patients who died in Mahalapye District, Botswana, while on anti-TB medication and the factors that contributed to such outcome.Setting: The study was conducted in the Mahalapye Health District in Botswana.Methods: This was a cross-sectional study that reviewed patient records from the Mahalapye District Health Management Team Electronic Tuberculosis Register from January 2013 to December 2015.Results: The majority of the TB and HIV co-infected patients were on antiretroviral therapy (ART) (486 [81.63%]) or were initiated cotrimoxazole preventive therapy (CPT) (518 [87.2%]) while taking anti-TB treatment. Seventy-three (13.6%) TB and HIV co-infected patients died before completing anti-TB treatment. Three-quarters (54 [74.4%]) of patients who died before completing anti-TB treatment were on ART, among them two patients who were on ART at least 3 months prior to commencing anti-TB. Also, the majority (64 [87.7%]) of TB and HIV co-infected patients were commenced on CPT prior to death. There was a bimodal density curve of death occurrence in those who did not commence ART and in those who did not commence CPT.Conclusion: This study established that TB and HIV co-infected patients had a TB mortality of 13.6%. A high mortality rate was observed during the first 3 months in those who did not take ART and during the second and the fifth month in those who did not commence CPT. Further study is needed to clarify this matter.
Possible acute rejection associated with the use of the new antihepatitis C virus medications
Authors: Karkout Khaled Ar , Al Sherif Saleema , Hussein Qutaiba , Albawardi Alia , Boobes Yousef 
Published: November 2018

AbstractHepatitis C virus infection is associated with increased morbidity and mortality. It remains a major challenge for management and treatment, especially in patients with renal transplant. The new directacting antiviral agents gave big hopes to both clinicians and patients that they can overcome this challenge without major side effects. Studies recently have supported this claim; however, they are still few, limited, and may give false hopes. In the following case report, we present a case, supported by histological evidence about a possible acute rejection of kidney transplant after treatment with these new medications. This case is limited by the absence of donorspecific antibodies. This report is aimed to increase awareness about the urgent need for further studies.
Temporal evolution of flow-like landslide hazard for a road infrastructure in the municipality of Nocera Inferiore (southern Italy) under the effect of climate change
Authors: Uzielli Marco , Rianna Guido , Ciervo Fabio , Mercogliano Paola , Eidsvig Unni K. 
Published: November 2018

Abstract. In recent years, flow-like landslides have extensively affected pyroclastic
covers in the Campania region in
southern Italy, causing human suffering and conspicuous economic damages. Due to the high
criticality of the area, a proper assessment of future variations in event
occurrences due to expected climate changes is crucial. The study assesses
the temporal variation in flow-like landslide hazard for a section of the A3
“Salerno–Napoli” motorway, which runs across the toe of the Monte Albino
relief in the Nocera Inferiore municipality. Hazard is estimated spatially
depending on (1) the likelihood of rainfall-induced event occurrence within
the study area and (2) the probability that the any specific location in the
study area will be affected during the runout. The probability of
occurrence of an
event is calculated through the application of Bayesian theory. Temporal
variations due to climate change are estimated up to the year 2100
through an ensemble of high-resolution climate projections, accounting for
current uncertainties in the characterization of variations in rainfall
patterns. Reach probability, or defining the probability that a given spatial
location is affected by flow-like landslides, is calculated spatially based
on a distributed empirical model. The outputs of the study predict substantial
increases in occurrence probability over time for two different scenarios of
future socioeconomic growth and
atmospheric concentration of greenhouse gases.