bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodale Therapie der kaninen Osteoarthritis – aktueller Stand und neue Optionen
Authors: Tünsmeyer Julia , Diehm Marius 
Published: December 2018

ZusammenfassungDie Osteoarthritis des Hundes ist eine sehr oft vorkommende Erkrankung und die häufigste Ursache für chronische Schmerzen beim Hund. Durch eine progressive Degeneration des Gelenkknorpels sowie weiterer Gelenkstrukturen kommt es zur konsekutiven Entwicklung osteophytärer Zubildungen sowie Entzündungsreaktionen und Schmerz. Eine vollständige Heilung ist nicht möglich. Ein multimodales Behandlungsschema zielt darauf ab, das Fortschreiten der Erkrankung zu verlangsamen und die Lebensqualität des Hundes zu steigern. Der Artikel gibt einen Überblick zu den verschiedenen Therapieoptionen. Derzeit wird eine Vielzahl von Analgetika zur pharmazeutischen Therapie der Osteoarthritis eingesetzt. Für eine effektive Behandlung dieser Erkrankung ist eine antientzündliche Wirkung sehr wichtig, doch geht insbesondere die langfristige Anwendung antiinflammatorisch wirksamer Medikamente mit erheblichen Nebenwirkungen einher. Durch eine für den Hund neu zugelassene Wirkstoffklasse, die sogenannten Piprante, besteht die Hoffnung auf ein verbessertes Sicherheitsprofil bei der medikamentösen Therapie chronisch entzündlicher Gelenkerkrankungen.
BRCA1/2 Functional Loss Defines a Targetable Subset in Leiomyosarcoma
Authors: Seligson Nathan D. , Kautto Esko A. , Passen Edward N. , Stets Colin , Toland Amanda E. , Millis Sherri Z. , Meyer Christian F. , Hays John L. , Chen James L. 
Published: December 2018

Abstract

Background
Soft-tissue sarcomas (STS) describe a heterogeneous group of mesenchymal tumors with limited treatment options. Targeted therapies exist for BRCA1/2 gene alterations, but their prevalence and role have not been fully described in STS. Here, we present the largest effort to characterize the frequency of homologous recombination (HR) DNA repair pathway alterations in STS subtypes and highlight the unique nature of leiomyosarcoma (LMS).

Materials and Methods
DNA sequencing data were analyzed for HR pathway alterations for 1,236 patients with STS. DNA sequencing data from an additional 1,312 patients were used to confirm the prevalence of HR pathway alterations in LMS. Four uterine LMS (uLMS) patients with functional BRCA2 loss were evaluated for response to poly (ADP-ribose) polymerase (PARP) inhibition.

Results
In an unselected STS study population, BRCA2 alterations were identified in 15 (1%) patients, and homozygous BRCA2 loss was detected in 9 (&lt;1%). However, subset analysis revealed that these BRCA2 alterations were concentrated in uLMS as compared with any other STS subtype. Notably, 10% of uLMS tumors had a BRCA2 alteration. We further report that PARP inhibitors had demonstrated durable clinical benefit in four uLMS patients with BRCA2 loss.

Conclusion
HR pathway alterations are rare in most STS. However, we identify uLMS to be enriched for BRCA2 loss and report the positive outcomes of a series of patients treated with PARP inhibitors. Our data suggest that patients with uLMS should be considered for somatic BRCA2 profiling. Prospective trials are necessary to confirm the efficacy of PARP inhibition in uLMS.
Biomarkers for Programmed Death-1 Inhibition in Prostate Cancer
Authors: Manogue Charlotte , Cotogno Patrick , Ledet Elisa , Lewis Brian , Wyatt Alexander W. , Sartor Oliver 
Published: December 2018

Abstract

Prostate cancer is the second leading cause of cancer death in American men. Despite the common nature of this disease, there is a poor understanding of biomarkers that predict responsiveness to immunotherapeutic agents such as the programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) inhibitors. Herein we describe a case of complete remission with pembrolizumab therapy in a metastatic castrate-resistant prostate cancer patient with a complex germline MSH2 alteration (Boland inversion) in association with a tumor demonstrating high microsatellite instability. Potential utility of high mutational burden assessed by an experimental circulating tumor DNA assay is also shown. The literature concerning biomarkers for PD-1 inhibition is reviewed, including data for various mismatch repair gene deficiencies, microsatellite instability, tumor mutational burden, PD-L1 3' untranslated region mutations, selected POLE mutations, and biallelic CDK12 mutations. Taken together, although prostate cancer is generally believed to be a tumor unresponsive to PD-1 inhibition, careful dissection of tumor biology is able to provide an approach toward predictive biomarkers that has the potential for expanded clinical utility.

Key Points
Biomarkers for anti-PD1 and anti-PDL1 therapy are poorly defined in prostate cancer. Recent advances are defining new important classes of responsive patients.
Luces y sombras del derecho fundamental al olvido
Authors: Garcete Juan Marcelino González 
Published: December 2018

La humanidad ha avanzado en diversas áreas del saber, y ello genera, lógicamente el advenimiento de nuevos escenarios de ineludible interactuar. Somos conscientes, empero, que si bien es cierto que mayormente podríamos decir que son en beneficio de la humanidad, ello no es óbice para que se configure también, inconvenientes, situaciones no deseables, perjudiciales, etc.
Así, bajo el título de luces y sombras del derecho fundamental al olvido, analizaremos sucintamente este tema; puesto que el Derecho fiel a su naturaleza de ser sombra que sigue la realidad, para hacer posible la convivencia del ser humano en sociedad; advierte situaciones acontecidas en y como producto de la cada vez más masificada utilización de la Internet. Nos referimos, a la problemática —según nuestro modesto entender—que sobreviene a los efectos del incorrecto tratamiento de la información personal contenida en ella.
Florisztikai felmérések hibaforrásai I. „Jószándékú” flórahamisítások: „kakukk” a Medvesen
Authors: Csiky János , Lantos István 
Published: December 2018

A tervezett cikksorozat a florisztikai térképezések, illetve az így keletkezett adatbázi­sok hibaforrásaira szeretné felhívni a figyelmet. E dolgozatban elsőként a „jószándékú” flórahamisítás esetét mutatjuk be egy kistáj, a Medves vidék példáján. Az adatok forrását azok a 2005-ben postázott levelek képezik, amelyeket Varga Ferenc az elsőszerző kérésére fogalmazott meg. A dolgozatban 10, a tájegység és/vagy a Pannonicum szempontjából növényföldrajzilag is jelentős faj (Adonis vernalis, Arum orientale, Asarum europaeum, Genista germanica, Phragmites australis, Pulsatilla grandis, P. nigricans, Salvia aethiopis, Viola alba, Xeranthemum annuum) átültetésének körülményeit listáz­zuk. A levelezésekből kiderül, hogy amatőr botanikusként milyen módon szólhatunk bele egy terület flórájának alakulásába. A fajok döntő részét Varga Ferenc déli irányból észak felé mozdította el, átlago­san mintegy 10 km-nyire az eredeti termőhelyüktől. Az Adonis vernalis és a Genista germanica kivételé­vel legalább egy áttelepítés sikeresen, meghonosodással végződött. A Salvia aethiopis esetében az új állomány csupán 1,25 km-nyire található Szlovákiától, ahol a faj már kifejezetten ritka, veszélyeztetett (EN) taxon.
Catheter-associated urinary tract infections in patients of TSBHI “Altai territory hospital for war veterans” urological unit
Authors: Sursyakova K. I. , Safyanova T. V. 
Published: December 2018

Aim. To assess manifestations and risk factors of epidemiological process of catheter-associated urinary tract infections (UTI) in patients of the urological unit of “Altai Territory Hospital for War Veterans” (ATHWV).
Materials and methods. One hundred medical records of UTI patients, treated in this urological unit were analyzed to determine the association between the UTI sickness rate and the insertion of catheters among patients, treated in the urological unit of “Altai Territory Hospital for War Veterans” during 2017.
Results. Assessment of epidemiological process in catheter-associated UTI patients of “ATHWV” urological unit resulted in the following: UTI sickness rate in “ATHWV” is associated with urinary bladder catheterization and can be interpreted as health care-associated infections since all the observed patients underwent urinary tract catheterization procedure in conditions of “ATHWV” urological unit.
Conclusions. Microbiological urine analysis with determination of antibiotic-resistance and disinfectant-resistance of the excreted pathogens should be conducted in all the patients, who undergo urinary bladder catheterization procedure since there is a high percentage of microbiologically-evidenced symptomatic UTI (35.9 %).
ULUSLARARASI TİCARETİN GELECEĞİ İNSANSIZ GEMİLER: GZFT ANALİZİ VE HUKUKİ BOYUTLARI
Authors: ECE Nur Jale 
Published: December 2018

Denizcilik taşımacılığında yakıt tüketimi, çevre
kirliliği ve insan hatasından kaynaklanan deniz kazalarını azaltmak ve yeşil
taşımacılık sağlamak amacıyla insansız gemiler denizcilik sektörünün
gündemindedir. İnsansız gemilerin; gemi sahipleri, daha fazla enerji
tasarrufu, seyir emniyeti ve çevre güvenliği açısından denizcilik sektörüne
birçok yararı olacaktır. Ancak insansız gemilerin; siber saldırılar, iş kayıpları, gemi adamlarının becerilerine olumsuz
etkileri, yüke ilişkin kazaların artması vb. yeni riskleri de beraberinde
getireceği düşünülmektedir. Çalışmanın amacı uluslararası ticaretin geleceği insansız
gemilerin güçlü ve zayıf taraflarını, fırsat ve tehditleri (GZFT) ortaya koymak, insansız gemilerin
hukuki boyutlarını inceleyerek yapılması gereken hukuki ve teknik düzenlemelere
ilişkin önerilerde bulunmaktır. Çalışmada, dünyada insansız gemilere ilişkin
çalışmalar, sorunlar veriskler incelenmiş, insansız gemilerin Güçlü ve Zayıf
Yönler, Fırsatlar ve Tehditler (GZFT) Analizi yapılmış, 1982 Uluslararası Birleşmiş Milletler Deniz Hukuku Sözleşmesi,
Uluslararası Denizcilik Örgütü Sözleşmeleri, diğer uluslararası denizcilik
sözleşmeleri ve ulusal mevzuatta insansız gemiler ile ilgili düzenlemeler
gözden geçirilmiş olup, söz konusu mevzuatta yapılması gereken düzenlemelere
ilişkin öneriler verilmiştir.
Avaliação histopatológica dos órgãos de camundongos com carcinoma de ehrlich tratados com cisplatina, acupuntura e euphorbia tirucalli l.
Authors: Dias Mirella , Nascimento Tamires Saches Santos do , Souza Ivone Antônia de , Lima Evilda Rodrigues de 
Published: December 2018

Introdução: O câncer é uma das maiores causas de morte do mundo sendo considerado um problema de saúde pública. Objetivo: Objetivou-se realizar a avaliação histopatológica de órgãos de camundongos com carcinoma de Erhlich tratados com cisplatina, acupuntura e a planta Euphorbia tirucalli L. Metodologia: Utilizou-se 25 camundongos, fêmeas, com 60 dias de idade, 25 e 35 g de peso corpóreo sendo divididos em Grupo 1 – Controle negativo - 1ml de Soro Fisiológico 0,9% (VO); Grupo 2 – Controle positivo - 2,5mg/kg de Cisplatina (VO); Grupo 3 - Pré-tratamento com acupuntura + 2mg/kg da Euphorbia tirucalli (VO); Grupo 4 – Acupuntura; Grupo 5 - Acupuntura + 2mg/kg Euphorbia tirucalli (VO). Inoculou-se células do carcinoma em todos os animais e durante 8 dias foi realizado os protocolos terapêuticos. No nono dia os camundongos foram pesados, eutanasiados por deslocamento cervical, necropsiados para avaliação macroscópica e histológica dos órgãos e do tumor. Os acupontos utilizados foram B10, VB30 e F3. Resultados: Houve variação significativa no peso dos órgãos (Rins, Baço, Fígado) e do Tumor. As principais alterações histopatológicas foram pneumonia, hepatite, necrose hepática, degeneração gordurosa e hiperplasia da polpa branca do baço. Conclusão: A cisplatina demonstrou ser o tratamento mais eficaz em camundongos com carcinoma de Erhlich quanto a redução do tumor. A dose utilizada na pesquisa do látex da Euphorbia tirucalli L. demonstrou ser hepatotóxica, no entanto os tratamentos com acupuntura e a planta proporcionaram uma resposta imunológica. Assim, sugere-se a associação da acupuntura e da Euphorbia tirucalli como tratamentos coadjuvantes em pacientes com carcinoma.Palavras-chaves: Câncer. Etnobotânica. Fitoterapia. Medicina Tradicional Chinesa.
The Flipped Classroom in 21st Century Learning for Development of learning skills Algorithm Analysis of Basic Programming C Language
Authors: Kunpitak Piyamart 
Published: December 2018

Learning management of flipped classroom is a learning style that brings technology to the flipped classroom. The concept is "Study at home - homework at school" to develop the 21st century education which is a new paradigm learning style considered as a basic technology education. Learning with advanced technology will improve the development of learning skills Algorithm analysis of basic programming C language Throughout the course. The students will be encouraged to create a learning conducive environment. The objectives of this study were 1) to evaluate the achievement of flipped classroom concept learning, 2) to evaluate students' satisfaction with the management of flipped classroom concept learning. The sample was 22 undergraduate students majoring in Computer Science. The statistics used for data analysis included mean, standard deviation for the comparison of teaching achievement. The results showed that the students' achievement through flipped classroom concept learning was higher, interpreted from the pre-test ( = 4.41, S.D. = 0.94) and the post-test ( =6.64, S.D. = 1.16). It can be said that the students' achievement grades after learning were obviously more higher than the pre-test. The evaluation of students' satisfaction on learning and teaching activities based on the concepts of flipped classroom was overall at a high level ( = 4.47, S.D. = 0.39).
First Cross-Dipole Shear Wave Imaging Application for Intersecting a Mother Open-Hole from a Near-Parallel Side-Track Wellbore
Authors: Franquet Javier Alejandro , Singh Rudra Pratap , Diaz Nerwing , Anurag Atul , Balooshi Mohamed Ali , Jefri Ghassan Al , Hosany Khalid Ibrahim , Cesetti Mauricio , Kindi Rashid Khudaim , Zhunussova Gulzira , Bradley Tom , Kirby Cliff 
Published: December 2018

Abstract
An injector well drilled from an artificial island in UAE left a non-magnetic fish during well control operations across lower Cretaceous reservoirs below the 9⅝-in. casing shoe, exposing all upper Jurassic reservoirs flow units. The situation was a serious concern to field developing and reservoir integrity as aquifer, gas and many layers of oil reservoirs were connected through the borehole below the fish. It was decided to sidetrack around the fish to intersect the original 8½-in. open-hole section. The sidetrack was accomplished, but the first attempt to intersect the mother hole was unsuccessful. Therefore, an innovative solution was needed for detecting the mother hole to intersect it.
A combination of cross-dipole deep shear acoustic, high-resolution induction and orientation wireline measurements were advised. These measurements would be used to update the wellbore survey and to detect acoustic reflections from the mother hole for identifying its relative orientation with respect to the sidetrack hole. Detailed measurement-while-drilling (MWD) wellbore survey analyses were conducted for the original and sidetrack holes beside typical corrections, such as Sag and drillstring interference. The deep shear wave imaging data recorded in the side-track hole was processed at multiple X-dipole polarization directions to detect shear reflection from the mother-hole and back calculate its relative position.
The high-resolution induction data could not detect the fish from the sidetrack, but few dipole reflections of the mother hole were detected in two locations. The orientation of the reflectors was consistent with the revised wellbore survey analysis, and this information was used to make the directional drilling corrections required to intersect the mother hole. The use of deep shear wave imaging data to identify a nearby open hole was a non-conventional application of this technology, but it definitely facilitated directional drilling operations to successfully intersect a mother hole that cannot be left uncompleted. After the openhole intersection, a good borehole condition was encountered due to the non-damaging fluid system, allowing the well to be completed as per original plan. Achieving this challenging directional drilling objective was critical for the field development plan of these offshore UAE reservoirs.
This case study represents the first documented field experience of using deep shear wave imaging data in the petroleum industry for assisting directional drillers to intersect an open hole mother wellbore after sidetracking a fish.
The role of PKCγ subunit of rACC neurons in the development of bone cancer pain in rats
Authors: Feng Hao , Feng Zequn , She Meng , Wang Gongming , Cheng Guanghui , Li Kailin , Wang Ruoyi , Li Xiaohui 
Published: December 2018

Abstract
Background: To explore the role of PKCγ subunit of rACC neurons in the development of bone cancer pain in rats.
Methods: 32 adult female SD rats were divided into four groups: blank control group (Naive group), sham operation group (Sham group), bone cancer pain group (BCP group) and PKCγ/shRNA recombinant lentiviral vector group (PKCγ group). 10μl MADB-106 rat mammary cancer cells suspension, 10μl saline was inoculated into the proximal tibia bone marrow cavity of rats in BCP group and Sham group respectively. In the PKCγ group, the rats were taken the same treatment as the BCP group, and then 10μl shRNA/NR2B recombinant lentivirus was injected into the bilateral rACC on the 7th day. The mechanical withdrawal threshold and thermal withdrawal latency were measured every 3 days to assess the rat pain behavior. Immunohistochemistry and Western blotting technology were used to detect the expression of PKCγ subunits in rat rACC neurons after operation.
Results: There was no significant difference in the mechanical withdrawal threshold and thermal withdrawal latency between the four groups (P>0.05). From the 3rd day after operation, the mechanical withdrawal thresholds in BCP group and PKCγ group were significantly decreased than those in Naive group and Sham group (P<0.05). Compared with the BCP group, the mechanical withdrawal threshold in the PKCγ group increased significantly (P<0.05). On the 3rd postoperative day, the thermal withdrawal latency in BCP and PKCγ groups was significantly longer than those in Naive and Sham groups（P＜0.05). From the 10th postoperative day, the thermal withdrawal latency in PKCγ group was shorter than that in BCP group (P<0.05). Western blot analysis showed that the expression of PKCγ in rACC neurons on the 14th day after operation in rats of BCP group was significantly higher than that in Naive group and Sham group. (P<0.05) However, in the PKCγ group, the expression of PKCγ in rACC neurons was significantly lower than that in BCP group (P<0.05).
Conclusion: Up-regulation of PKC subunit of rACC neurons in bone cancer pain rats may be involved in the development of pain sensitivity in bone cancer.
Key words: Bone cancer pain; rat; rACC; PKCγ; gene silencing
The Effects of Epidural Anesthesia and Analgesia on Cluster of Differentiation and Cytokines in Patients after Gastric Cancer Resection
Authors: Liang Si , Wang MD Liping , Chen MD Hong , Xu MD Yang , Wang MD Yu 
Published: December 2018

Abstract
Background: Epidural use can prevent peri-operative neuro-endocrine stress responses, improve pain after surgery, and reduce opioid volume which lead to immunosuppression.
Methods: Forty cases of patients with gastric cancer were finally enrolled into the study. Patients who received general anesthesia (GA group, n=20), a combination of general anesthesia and peri-operative epidural use (EGA group, n=20), were given intravenous analgesia or epidural analgesia, respectively. We collected visual analogue scale (VAS) scores, length of hospital stay, the first passage of flatus time and incidence of postoperative nausea and vomiting (PONV). We also collected the Cluster of Differentiation (CD)3+, CD4+, CD8+, CD4+/CD8+, Interleukin (IL)-4, IL-6, Interferon (IFN)-γ before surgery, as well as the postoperative days 1, 3 ,7.
Results: VAS scores and PONV in GA group were higher than EGA group in the postoperative 3 days. CD3+, CD4+, CD4+/CD8+ were declined in the postoperative 3 days, and nearly recovered to the baseline in the seventh days after surgery in both of the two groups. CD3+ in the GA group decreased more than EGA group. IL-4, IL-6, IFN-γ were increased in the postoperative 3 days, and nearly recovered to the baseline in the seventh days after surgery in both of the two groups, IL-4, IL-6 in the GA group increased more than EGA group. IFN-γ in the EGA group increased more than GA group.
Conclusions: A combination of general anesthesia and peri-operative epidural use can relieve postoperative pain and PONV. A combination of general anesthesia and peri-operative epidural use decreases immunosuppression in gastric cancer resection.
Diagnostic Test Accuracy of Diabetic Retinopathy Screening by Physician Graders Using a Hand Held Non-Mydriatic Retinal Camera at a Tertiary Level Medical Clinic in a Lower-Middle Income Country Setting
Authors: Piyasena Mapa Mudiyanselage Prabhath Nishantha , Yip Jennifer L.Y. , MacLeod David , Kim Min , Gudlavalleti Venkata S. Murthy 
Published: December 2018

Abstract
Background
We identified that there was less evidence on diagnostic test accuracy (DTA) of diabetic retinopathy (DR) screening photographic studies that have used non-ophthalmologist human resources in low and middle-income country (LMIC) settings. This study is the first to assess the DTA of physician graders using hand held digital imaging in Sri Lanka. We aimed to assess DTA of DR screening using a nonmydriatic hand-held digital camera by trained general physicians in a non-ophthalmic setting. This modality will be useful for adaptation in similar settings.
Methods
This study is a validation of a screening intervention. We selected people with diabetes (PwDM) not previously screened or treated for DR, presenting at a tertiary medical clinic in Sri Lanka. Two-field retinal imaging was used to capture fundus images before and after pupil dilatation. The images were captured and graded by two trained, masked independent physician graders. The DTA of different levels of DR was assessed comparing physician’s grading with a retinologist’s clinical examination according to a locally adopted guideline.
Results
Seven hundred eligible PwDM were screened by physician graders. Their mean age was 60.8 years (SD ±10.08) and mean duration of DM was 9.9 years (SD ±8.09). Ungradable image proportion in non-mydriatic imaging was 43.4% (either eye-31.3%, both eyes 12.1%). This decreased to 12.8% (either eye-11.6%, both eyes-1.2%) following pupil dilatation. In comparison to detection of any level of DR, a referable level DR (moderate non-proliferative DR and levels above) showed a higher level of DTA. The sensitivity of the defined referable DR was 88.7% (95% CI 81.7-93.8%) for grader 1 (positive predictive value [PPV] 59.1%) and 92.5% (95% CI 86.4-96.5%) for grader 2 (PPV 68%), using mydriatic imaging, after including ungradable images as screen positives. The specificity was 94.9% (95% CI 93.6-96.0%) for grader 1 (negative predictive value [NPV] 99%) and 96.4% (95% CI 95.3-97.3%) for grader 2 (NPV 99.4%).
Conclusions
The Physicians grading of images from a digital hand-held nonmydriatic camera was effective in identifying referable DR, following pupil dilatation. This could be a feasible alternative modality to the existing opportunistic screening to improve the access and coverage.