bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes
Authors: Chu Yaping , Muller Scott , Tavares Adriana , Barret Olivier , Alagille David , Seibyl John , Tamagnan Gilles , Marek Ken , Luk Kelvin C , Trojanowski John Q , Lee Virginia M Y , Kordower Jeffrey H 
Published: September 2019

AbstractSeveral studies have demonstrated that intrastriatal injections of fibrillar α-synuclein in rodent brain induced a Parkinson’s disease-like propagation of Lewy body pathology with significant nigrostriatal neurodegeneration. This study evaluated the pathological features when exogenous α-synuclein preformed fibrils were injected into the putamen of non-human primates. Eight cynomolgus monkeys received unilateral intraputamen injections of α-synuclein preformed fibrils and four monkeys received sham surgery. Monkeys were assessed with 123I-PE2I single-photon emission computerized tomography scans targeting the dopamine transprter at baseline, 3, 6, 9, 12, and 15 months. Imaging revealed a robust increase in dopamine transporter binding, an effect confirmed by port-mortem immunohistochemical analyses, suggesting that upregulation of dopamine transporter occurs as part of an early pathological process. Histochemistry and immunohistochemistry revealed that α-synuclein preformed fibrils injections into the putamen induced intraneuronal inclusions positive for phosphorylated α-synuclein in ipsilateral substantia nigra and adjacent to the injection site. α-Synuclein inclusions were thioflavin-S-positive suggesting that the inclusions induced by α-synuclein preformed fibrils exhibited pathological properties similar to amyloid-like Lewy body pathology in Parkinson’s disease brains. The α-synuclein preformed fibrils resulted in Lewy pathology in the ipsilateral substantia nigra with significant reduction (−29.30%) of dopaminergic neurons as compared with controls. Nigral neurons with α-synuclein inclusions exhibited a phenotypic downregulation of the dopamine markers tyrosine hydroxylase and Nurr1. Taken together, our findings demonstrate that α-synuclein preformed fibrils induce a synucleinopathy in non-human primates with authentic Lewy pathology and nigrostriatal changes indicative of early Parkinson’s disease.
Virtual resection predicts surgical outcome for drug-resistant epilepsy
Authors: Kini Lohith G , Bernabei John M , Mikhail Fadi , Hadar Peter , Shah Preya , Khambhati Ankit N , Oechsel Kelly , Archer Ryan , Boccanfuso Jacqueline , Conrad Erin , Shinohara Russell T , Stein Joel M , Das Sandhitsu , Kheder Ammar , Lucas Timothy H , Davis Kathryn A , Bassett Danielle S , Litt Brian 
Published: September 2019

Abstract
Patients with drug-resistant epilepsy often require surgery to become seizure-free. While laser ablation and implantable stimulation devices have lowered the morbidity of these procedures, seizure-free rates have not dramatically improved, particularly for patients without focal lesions. This is in part because it is often unclear where to intervene in these cases. To address this clinical need, several research groups have published methods to map epileptic networks but applying them to improve patient care remains a challenge. In this study we advance clinical translation of these methods by: (i) presenting and sharing a robust pipeline to rigorously quantify the boundaries of the resection zone and determining which intracranial EEG electrodes lie within it; (ii) validating a brain network model on a retrospective cohort of 28 patients with drug-resistant epilepsy implanted with intracranial electrodes prior to surgical resection; and (iii) sharing all neuroimaging, annotated electrophysiology, and clinical metadata to facilitate future collaboration. Our network methods accurately forecast whether patients are likely to benefit from surgical intervention based on synchronizability of intracranial EEG (area under the receiver operating characteristic curve of 0.89) and provide novel information that traditional electrographic features do not. We further report that removing synchronizing brain regions is associated with improved clinical outcome, and postulate that sparing desynchronizing regions may further be beneficial. Our findings suggest that data-driven network-based methods can identify patients likely to benefit from resective or ablative therapy, and perhaps prevent invasive interventions in those unlikely to do so.
An 18-month comparison of clinical outcomes between continuous-flow left ventricular assist devices
Authors: Itzhaki Ben Zadok Osnat , Ben-Avraham Ben , Shaul Aviv , Hammer Yoav , Rubachevski Victor , Aravot Dan , Kornowski Ran , Ben-Gal Tuvia 
Published: September 2019

Abstract

OBJECTIVES
In this study, we aimed to determine the comparative outcomes of patients supported with continuous-flow left ventricular assist devices (LVADs): HeartMate 2 (HM2), HeartWare (HW) and HeartMate 3 (HM3) in a real-world setting.

METHODS
The study was an investigator-initiated comparative retrospective analysis of patients who underwent continuous-flow LVAD implantation at our institution between 2008 and 2017. The follow-up duration was 18 months after implantation.

RESULTS
The study included 105 continuous-flow LVAD-supported patients of whom 51% (n = 54), 24% (25) and 25% (26) underwent implantation of HM2, HW and HM3, respectively. During follow-up, patients who were supported with HM3 versus either HM2 or HW LVADs demonstrated a lower risk of stroke (0% vs 26%, P < 0.001 and 0% vs 40%, P < 0.001, respectively) and lower rates of thrombosis (0% vs 31%, P < 0.001 and 0% vs 12%, P < 0.001, respectively), findings that were consistent with their calculated haemocompatibility scores (cumulative score 5, 89 and 56 for HM3, HM2 and HW, respectively, P < 0.001). Moreover, patients supported with HM3 versus HW had fewer unplanned hospitalizations [median 1 (25th–75th interquartile range 0–2) vs 3 (interquartile range 2–4), P = 0.012]. Importantly, survival free from stroke or device exchange was higher in patients supported with HM3 compared with either the HM2 or the HW LVADs [hazard ratio (HR) 2.77, confidence interval (CI) 1.13–6.78; P = 0.026 and HR 2.70, CI 1.01–7.20; P = 0.047, respectively].

CONCLUSIONS
HM3 device currently presents better prognostic and adverse events profiles when compared with the HM2 or the HW LVADs. A larger-scale head-to-head comparison between the devices is warranted in order to confirm our findings.
Status and prospects of nutritional cooking
Authors: Yong Wang , Amin Li , Dongpo Chen 
Published: September 2019

Abstract
With the rapid development of national economic level, people’s living standards have been greatly improved, leading to people’s higher attention to their daily diet. However, there are still a great number of people who have not realized the importance of healthy diet, which could result in many health problems such as under-nutrition or over-nutrition. The cooking process has a significant impact on food nutrition, thus a fast, convenient and healthy new cooking process has a great potential to be developed and applied in our daily life.
The Medieval in the Modern: Nazi and Italian Fascist Use of the Ritual Murder Charge
Authors: Kertzer David I , Mokosch Gunnar 
Published: September 2019

Abstract
Addressing both the debate over the “modern” nature of the German and Italian fascist regimes, and the related question of the role played by the Christian churches in making the Holocaust possible, we examine the most prominent antisemitic publications aimed at the broad public in each country: Der Stürmer in Germany and La Difesa della razza in Italy. Our study traces the heavy use of the ritual murder charge in both publications, and demonstrates the direct influence of the Nazi antisemitic campaign on the subsequent Italian one. Differences between the two publications in their use of the ritual murder charge are linked to differences between the two regimes in their relations to Christianity and the Christian churches.
Preoperative VolumE Replacement therapy in DIabetic patients undergoing coronary artery bypass grafting surgery: results from an open parallel group randomized Controlled Trial (VeRDiCT)
Authors: Sarkar Kunal , Harris Rosie A , Wells Sian , Harris Tracy , Clout Madeleine , Taylor Jodi , Culliford Lucy , Angelini Gianni D , Pike Katie , Ashton Kate , Narayan Pradeep , Reeves Barney , Hillier James , Rogers Chris A , Ascione Raimondo 
Published: September 2019

Abstract

OBJECTIVES
To investigate the effect of preoperative volume replacement therapy (VRT) on renal function, health outcome and time to fitness for discharge in diabetic patients undergoing coronary artery bypass grafting (CABG).

METHODS
In 2 parallel randomized controlled trials, diabetic patients were allocated to preoperative VRT (1 ml/kg/h of Hartmann’s solution for 12 h) or usual care. Primary outcome was time to fitness for discharge. Secondary outcomes included acute kidney injury, postoperative complications, patient-reported quality of life (QoL), hospital resource use and markers of renal, cardiac and inflammatory injury.

RESULTS
In total, 169 patients were randomized (84 VRT, 85 usual care; mean age 64 years; 88% male). Time to fitness for discharge was similar between groups [median 6 days; interquartile range 5.0–9.0 in both groups; hazard ratio 0.95, 95% confidence interval (CI) 0.65–1.38; P = 0.78]. Postoperative acute kidney injury was not statistically different (VRT: 27.7% vs usual care: 18.8%, odds ratio 1.72, 95% CI 0.82–3.59; P = 0.15). Estimated glomerular filtration rate (mean difference −0.92, 95% CI −4.18 to 2.25; P = 0.56), microalbumin/creatinine ratio [geometric mean ratio (GMR) 1.16, 95% CI 0.94–1.42; P = 0.16], N-acetyl-beta-d-glucosaminidase (GMR 1.08, 95% CI 0.83–1.40; P = 0.57), C-reactive protein (GMR 1.00, 95% CI 0.88–1.13; P = 0.94), troponin T (Trop-T; GMR 1.18, 95% CI 0.78–1.79; P = 0.39) and other secondary health outcomes were similar between groups. QoL improved in both groups at 3 months with no difference observed.

CONCLUSIONS
The use of preoperative VRT is not superior to usual care in diabetic patients undergoing CABG.

Clinical trial registration number
ISRCTN02159606.
A Characterization of Some Fano 4-folds Through Conic Fibrations
Authors: Montero Pedro , Romano Eleonora Anna 
Published: September 2019

Abstract
We find a characterization for Fano 4-folds $X$ with Lefschetz defect $\delta _{X}=3$: besides the product of two del Pezzo surfaces, they correspond to varieties admitting a conic bundle structure $f\colon X\to Y$ with $\rho _{X}-\rho _{Y}=3$. Moreover, we observe that all of these varieties are rational. We give the list of all possible targets of such contractions. Combining our results with the classification of toric Fano $4$-folds due to Batyrev and Sato we provide explicit examples of Fano conic bundles from toric $4$-folds with $\delta _{X}=3$.
Imputation and characterization of uncoded self-harm in major mental illness using machine learning
Authors: Kumar Praveen , Nestsiarovich Anastasiya , Nelson Stuart J , Kerner Berit , Perkins Douglas J , Lambert Christophe G 
Published: September 2019

Abstract

Objective
We aimed to impute uncoded self-harm in administrative claims data of individuals with major mental illness (MMI), characterize self-harm incidence, and identify factors associated with coding bias.

Materials and Methods
The IBM MarketScan database (2003-2016) was used to analyze visit-level self-harm in 10 120 030 patients with ≥2 MMI codes. Five machine learning (ML) classifiers were tested on a balanced data subset, with XGBoost selected for the full dataset. Classification performance was validated via random data mislabeling and comparison with a clinician-derived “gold standard.” The incidence of coded and imputed self-harm was characterized by year, patient age, sex, U.S. state, and MMI diagnosis.

Results
Imputation identified 1 592 703 self-harm events vs 83 113 coded events, with areas under the curve &gt;0.99 for the balanced and full datasets, and 83.5% agreement with the gold standard. The overall coded and imputed self-harm incidence were 0.28% and 5.34%, respectively, varied considerably by age and sex, and was highest in individuals with multiple MMI diagnoses. Self-harm undercoding was higher in male than in female individuals and increased with age. Substance abuse, injuries, poisoning, asphyxiation, brain disorders, harmful thoughts, and psychotherapy were the main features used by ML to classify visits.

Discussion
Only 1 of 19 self-harm events was coded for individuals with MMI. ML demonstrated excellent performance in recovering self-harm visits. Male individuals and seniors with MMI are particularly vulnerable to self-harm undercoding and may be at risk of not getting appropriate psychiatric care.

Conclusions
ML can effectively recover unrecorded self-harm in claims data and inform psychiatric epidemiological and observational studies.
Glyphosate in livestock: feed residues and animal health1
Authors: Vicini John L , Reeves William R , Swarthout John T , Karberg Katherine A 
Published: September 2019

AbstractGlyphosate is a nonselective systemic herbicide used in agriculture since 1974. It inhibits 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase, an enzyme in the shikimate pathway present in cells of plants and some microorganisms but not human or other animal cells. Glyphosate-tolerant crops have been commercialized for more than 20 yr using a transgene from a resistant bacterial EPSP synthase that renders the crops insensitive to glyphosate. Much of the forage or grain from these crops are consumed by farm animals. Glyphosate protects crop yields, lowers the cost of feed production, and reduces CO2 emissions attributable to agriculture by reducing tillage and fuel usage. Despite these benefits and even though global regulatory agencies continue to reaffirm its safety, the public hears conflicting information about glyphosate's safety. The U.S. Environmental Protection Agency determines for every agricultural chemical a maximum daily allowable human exposure (called the reference dose, RfD). The RfD is based on amounts that are 1/100th (for sensitive populations) to 1/1,000th (for children) the no observed adverse effects level (NOAEL) identified through a comprehensive battery of animal toxicology studies. Recent surveys for residues have indicated that amounts of glyphosate in food/feed are at or below established tolerances and actual intakes for humans or livestock are much lower than these conservative exposure limits. While the EPSP synthase of some bacteria is sensitive to glyphosate, in vivo or in vitro dynamic culture systems with mixed bacteria and media that resembles rumen digesta have not demonstrated an impact on microbial function from adding glyphosate. Moreover, one chemical characteristic of glyphosate cited as a reason for concern is that it is a tridentate chelating ligand for divalent and trivalent metals; however, other more potent chelators are ubiquitous in livestock diets, such as certain amino acids. Regulatory testing identifies potential hazards, but risks of these hazards need to be evaluated in the context of realistic exposures and conditions. Conclusions about safety should be based on empirical results within the limitations of model systems or experimental design. This review summarizes how pesticide residues, particularly glyphosate, in food and feed are quantified, and how their safety is determined by regulatory agencies to establish safe use levels.
Promotional Games Increase Consumer Conversion Rates and Spending
Authors: Hock Stefan J , Bagchi Rajesh , Anderson Thomas M 
Published: September 2019

Abstract
Promotional games are used frequently in retail stores and online. While prior literature has focused on antecedents of promotional games, such as how individual differences induce game participation, little is known about post-winning decision making or its underlying processes. This study offers findings from seven studies to provide a detailed perspective on how promotional games increase consumer conversion rates and spending. The effect of winning a discount on conversion rates and spending is multiply determined and occurs via perceptions of luck and store affective attitude, and via perceptions of luck alone and store affective attitude alone. In order to get a more nuanced understanding of the underlying processes and to delineate theoretically driven boundary conditions for this novel effect, the authors subsequently analyze the two individual pathways through perceptions of luck and store affective attitude in isolation. Thereby, they contribute to the literature on pricing and promotions by providing a detailed understanding on how winning a promotional discount leads to a different set of consumer inferences relative to an equivalent straight discount, and to the literature on the role of luck in consumer behavior by providing a nuanced understanding of how luck operates in this common consumer context.
Characterization of Nanostructured Silica as Carrier for Insecticides Deltamethrin, Pyriproxyfen, and Chlorpyrifos and Testing the Insecticidal Efficacy Against Trogoderma granarium (Coleoptera: Dermestidae) Larvae
Authors: Ziaee Masumeh , Babamir-Satehi Asgar 
Published: September 2019

Abstract
Nanostructured silica can be used as a carrier of pesticides to enhance stability and controlled release of agrochemicals with an effective concentration on target pests. Silica nanoparticles (SNPs) were synthesized by sol–gel process and employed as a carrier of three different insecticides including deltamethrin, pyriproxyfen, and chlorpyrifos. The SNPs were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis and the insecticides-loaded in SNPs were characterized by transmission electron microscopy (TEM). The toxicity of insecticides alone and loaded in SNPs was evaluated against small and large larvae of Trogoderma granarium Everts on concrete surfaces. The immediate mortality was counted after 1, 3, and 7 d of exposure, and then surviving individuals were transferred to untreated surfaces for seven more days, with delayed mortality was recorded. Small larvae were more susceptible than large ones on all insecticide treatments. In addition, insecticides loaded in silica nanoparticles were more effective when compared with application of the insecticides alone. For immediate mortality, deltamethrin loaded in SNPs was the most efficient treatment causing 70.5% mortality on small and 55.5% mortality on large larvae after 7 d of exposure to the highest concentration. Pyriproxyfen loaded in SNPs caused low immediate mortality, but the mortality increased in delayed count indicated that the insecticide could control the larvae even after they have been removed from treated surfaces. It can be concluded that loading insecticides in SNPs could significantly increase their insecticidal efficiency, but this increase was compound-dependent.
Multi-scale time-frequency domain full waveform inversion with a weighted local correlation-phase misfit function
Authors: Hu Yong , Han Liguo , Wu Rushan , Xu Yongzhong 
Published: September 2019

Abstract
Full Waveform Inversion (FWI) is based on the least squares algorithm to minimize the difference between the synthetic and observed data, which is a promising technique for high-resolution velocity inversion. However, the FWI method is characterized by strong model dependence, because the ultra-low-frequency components in the field seismic data are usually not available. In this work, to reduce the model dependence of the FWI method, we introduce a Weighted Local Correlation-phase based FWI method (WLCFWI), which emphasizes the correlation phase between the synthetic and observed data in the time-frequency domain. The local correlation-phase misfit function combines the advantages of phase and normalized correlation function, and has an enormous potential for reducing the model dependence and improving FWI results. Besides, in the correlation-phase misfit function, the amplitude information is treated as a weighting factor, which emphasizes the phase similarity between synthetic and observed data. Numerical examples and the analysis of the misfit function show that the WLCFWI method has a strong ability to reduce model dependence, even if the seismic data are devoid of low-frequency components and contain strong Gaussian noise.
How do immigrant legalization programs play out in informal labor markets? The case of Senegalese street hawkers in Argentina
Authors: Freier Luisa Feline , Zubrzycki Bernarda 
Published: September 2019

AbstractIn this article, we take advantage of the quasi-experimental situation of the 2013 legalization program for Senegalese citizens in Argentina to study its effects on immigrant street hawkers’ incorporation into the formal labor market, their working conditions, social integration, and collective mobilization. In order to understand the impact of legalization programs, it is important to acknowledge that in informal labor markets, the effects of amnesties are likely less pronounced than in predominantly formal markets. Furthermore, the scope of socioeconomic rights granted to unauthorized migrants and migrants’ subjective expectations and aspirations need to be taken into consideration. Based on 50 in-depth interviews and a small N survey, our study suggests that the legalization effect on Senegalese street hawkers’ access to the formal sector is limited. However, legal status does benefit migrants’ subjective well-being and their disposition to engage in collective action for labor and human rights.
A study of Kepler supernova remnant: angular power spectrum estimation from radio frequency data
Authors: Saha Preetha , Bharadwaj Somnath , Roy Nirupam , Choudhuri Samir , Chattopadhyay Debatri 
Published: September 2019

ABSTRACT
Supernova remnants (SNRs) have a variety of overall morphology as well as rich structures over a wide range of scales. Quantitative study of these structures can potentially reveal fluctuations of density and magnetic field originating from the interaction with ambient medium and turbulence in the expanding ejecta. We have used 1.5 GHz (L band) and 5 GHz (C band) VLA data to estimate the angular power spectrum Cℓ of the synchrotron emission fluctuations of the Kepler SNR. This is done using the novel, visibility-based, Tapered Gridded Estimator of Cℓ. We have found that, for ℓ = (1.9–6.9) × 104, the power spectrum is a broken power law with a break at ℓ = 3.3 × 104, and power-law index of −2.84 ± 0.07 and −4.39 ± 0.04 before and after the break, respectively. The slope −2.84 is consistent with 2D Kolmogorov turbulence and earlier measurements for the Tycho SNR. We interpret the break to be related to the shell thickness of the SNR (0.35 pc) which approximately matches ℓ = 3.3 × 104 (i.e. 0.48 pc). However, for ℓ > 6.9 × 104, the estimated Cℓ of L band is likely to have dominant contribution from the foregrounds while for C band the power-law slope −3.07 ± 0.02 is roughly consistent with 3D Kolmogorov turbulence like that observed at large ℓ for Cas A and Crab SNRs.