bluuebunny/crossref_metadata_2025_split huggingface dataset:
Satellite Orbital Drag During Magnetic Storms
Authors: Oliveira D. M. , Zesta E. 
Published: September 2019

AbstractWe investigate satellite orbital drag effects at low‐Earth orbit associated with thermosphere heating during magnetic storms caused by coronal mass ejections. CHAllenge Mini‐satellite Payload (CHAMP) and Gravity Recovery And Climate Experiment (GRACE) neutral density data are used to compute orbital drag. Storm‐to‐quiet density comparisons are performed with background densities obtained by the Jacchia‐Bowman 2008 (JB2008) empirical model. Our storms are grouped in different categories regarding their intensities as indicated by minimum values of the SYM‐H index. We then perform superposed epoch analyses with storm main phase onset as zero epoch time. In general, we find that orbital drag effects are larger for CHAMP (lower altitudes) in comparison to GRACE (higher altitudes). Results show that storm time drag effects manifest first at high latitudes, but for extreme storms, particularly observed by GRACE, stronger orbital drag effects occur during early main phase at low/equatorial latitudes, probably due to heating propagation from high latitudes. We find that storm time orbital decay along the satellites' path generally increases with storm intensity, being stronger and faster for the most extreme events. For these events, orbital drag effects decrease faster probably due to elevated cooling effects caused by nitric oxide, which introduce modeled density uncertainties during storm recovery phase. Errors associated with total orbit decay introduced by JB2008 are generally the largest for the strongest storms and increase during storm times, particular during recovery phases. We discuss the implication of these uncertainties for the prediction of collision between space objects at low‐Earth orbit during magnetic storms.
IFN-γ restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer
Authors: Yin Huijing , Jiang Zhengyu , Wang Shuoer , Zhang Ping 
Published: September 2019

AbstractRNase L is an essential component in interferon (IFN)-mediated antiviral signaling that showed antitumor effects in cancer. Cancer immunotherapy based on interferon has achieved encouraging results that indicate an applicable potential for cancer therapy. Here we showed that function of RNase L, though highly upregulated, was functionally impaired both in nuclear and cytoplasm in lung cancer cells. In normal lung epithelial cells, RNase L activation induced by 2–5A promoted nuclear condensation, DNA cleavage, and cell apoptosis, while in lung cancer cells, these processes were inhibited and RNase L-mediated downregulation of fibrillarin, Topo I and hnRNP A1 was also impaired in lung cancer cells. Moreover, the impairment of RNase L in lung cancer cells was due to the elevated expression of RLI. Application of IFN-γ to lung cancer cells led to enhanced expression of RNase L that compensated the RLI inhibition and restored the cytoplasmic and nuclear function of RNase L, leading to apoptosis of lung cancer cells. Thus, the present study discovered the impaired function and mechanism of RNase L in lung cancer cells and proved the efficacy of IFN-γ in restoring RNase L function and inducing apoptosis in the lung cancer cell. These results indicated the RNase L as a therapeutic target in lung cancer cells and immunotherapy of IFN-γ may serve as an adjuvant to enhance the efficacy.
Polyphenol-rich extract induces apoptosis with immunogenic markers in melanoma cells through the ER stress-associated kinase PERK
Authors: Prieto Karol , Cao Yu , Mohamed Eslam , Trillo-Tinoco Jimena , Sierra Rosa A. , Urueña Claudia , Sandoval Tito Alejandro , Fiorentino Susana , Rodriguez Paulo C. , Barreto Alfonso 
Published: September 2019

AbstractPolyphenols elicit antitumor activities, in part, through the induction of anti- or pro-oxidant effects in cancer cells which promote priming of protective anti-tumor immunity. We recently characterized a polyphenol-rich extract from Caesalpinia spinosa (P2Et) that stimulates in vivo antitumor responses against breast and melanoma tumor models via the promotion of immunogenic cancer cell death (ICD). However, the primary mediators whereby P2Et promotes ICD remained unknown. Here, we sought to elucidate the role that severe endoplasmic reticulum (ER) stress plays in mediating P2Et-induced apoptosis and ICD in murine melanoma cells. Our findings demonstrate a substantial selective induction of specific ER-stress mediators in B16-F10 melanoma cells treated with P2Et. While knockout of the ER stress-associated PKR-like ER kinase (PERK) prevented induction of apoptosis and expression of ICD markers in P2Et-treated cells, deletion of X-box binding protein 1 (Xbp1) did not. P2Et-driven activation of PERK in melanoma cells was found to promote ER-calcium release, disrupt mitochondrial membrane potential, and trigger upregulation of ICD drivers, surface calreticulin expression, and extracellular release of ATP and HMGB1. Notably, calcium release inhibition, but not targeting of PERK-driven integrated stress responses, prevented P2Et-induced apoptosis. Collectively, these results underline the central role of PERK-directed calcium release in mediating the antitumor and immunogenic actions of P2Et in melanoma cells.
G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10
Authors: Anisimov Sergei , Takahashi Masahiko , Kakihana Taichi , Katsuragi Yoshinori , Kitaura Hiroki , Zhang Lu , Kakita Akiyoshi , Fujii Masahiro 
Published: September 2019

AbstractThe aberrant accumulation of ubiquitinated protein aggregates in cells plays a critical role in the pathogenesis of several degenerative diseases, including Parkinson disease (PD) and cystic fibrosis (CF). In this study, we found that Ras GTPase-activating protein-binding protein 1 (G3BP1) inhibits ubiquitinated protein aggregations induced by p62 and USP10 in cultured cells. p62 is a ubiquitin receptor, and p62 and its binding partner USP10 have been shown to augment ubiquitinated protein aggregation. G3BP1 interacted with p62 and USP10 and inhibited p62/USP10-induced protein aggregation. The G3BP1 inhibition of protein aggregations targeted two aggregation-prone proteins, α-synuclein and CFTR-ΔF508, which are causative factors of PD and CF, respectively. G3BP1 depletion increased the amounts of ubiquitinated α-synuclein and CFTR-ΔF508 protein. A proteasome reporter indicated that G3BP1 depletion inhibits the proteasome activity. We herein present evidence that G3BP1, p62 and USP10 together control ubiquitinated protein toxicity by controlling both ubiquitination and aggregation. Taken together, these results suggest that G3BP1, p62 and USP10 could be therapeutic targets for ubiquitinated protein aggregation disorders, including PD and CF.
Excitotoxic neurodegeneration is associated with a focal decrease in metabotropic glutamate receptor type 5 availability: an in vivo PET imaging study
Authors: Crabbé Melissa , Dirkx Nina , Casteels Cindy , Laere Koen Van 
Published: September 2019

AbstractMetabotropic glutamate receptors (mGluRs) have been proposed as promising therapeutic targets to correct the dysregulated glutamate signaling, associated with neurodegenerative pathologies. Of all mGluR subtypes, especially mGluR5 acts as a modulator of glutamate-induced excitotoxicity. To study the behavior of mGluR5 following localized excitotoxicity, we utilised a pharmacological model that portrays exacerbated neuronal glutamate release, mediated by the endogenous excitotoxin quinolinic acid (QA). Using longitudinal positron emission tomography (PET) with [18F]FPEB, we investigated cerebral changes in mGluR5 following striatal QA-lesioning. Behavioral tests were executed to monitor motor and cognitive performance. Decreased mGluR5 binding potential (BPND) was found in the affected striatum and globus pallidus of QA-lesioned rats at week 3, and further decreased at week 7, as compared to sham-injected controls. mGluR5 availability in the ipsilateral nucleus accumbens was significantly decreased at 7 weeks post-injection. QA rats performed significantly worse on motor coordination and balance compared to control rats. Correlation analysis indicated a positive correlation between striatal mGluR5 BPND and rotarod performance whereas print width of the unaffected forepaws showed a positive relation with mGluR5 BPND in the contralateral motor cortex. Together, our results suggest decreased mGluR5 availability to be related to excitotoxin-induced neurodegeneration and symptomatology although late stage effects do indicate possible cortical mGluR5-mediated effects on motor behavior.
TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells
Authors: Whillock Amy L. , Mambetsariev Nurbek , Lin Wai W. , Stunz Laura L. , Bishop Gail A. 
Published: September 2019

AbstractTRAF3 is a versatile intracellular adapter protein with multiple context-specific roles. Uniquely in B cells, TRAF3 deficiency enhances survival and increases the risk of transformation, as loss of TRAF3 is observed in several types of B cell cancers. Here, we report a new mechanism for TRAF3 in the restraint of B cell survival. We found that TRAF3 deficiency was associated with induction of the pro-survival kinase Pim2 in mouse primary B cells and human malignant B cell lines. The increase in Pim2 was independent of NF-κB2 activation but was ameliorated with inhibition of STAT3 expression or function. TRAF3 deficiency also led to a Pim2-dependent increase in c-Myc protein levels and was associated with reduced c-Myc ubiquitination. TRAF3-deficient primary B cells were less sensitive to cell death induced by the Pim inhibitors SGI-1776 and TP-3654. Interestingly, human malignant B cell lines with low expression of TRAF3 were more sensitive to Pim inhibition-induced cell death. Combination treatment of TRAF3-deficient B cells and B cell tumor lines with c-Myc inhibitors enhanced their sensitivity to Pim inhibition, suggesting a possible therapeutic strategy. TRAF3 thus suppresses a Pim2-mediated B cell survival axis, which can be a potential target for treatment of B cell malignancies.
Automated tracking of level of consciousness and delirium in critical illness using deep learning
Authors: Sun Haoqi , Kimchi Eyal , Akeju Oluwaseun , Nagaraj Sunil B. , McClain Lauren M. , Zhou David W. , Boyle Emily , Zheng Wei-Long , Ge Wendong , Westover M. Brandon 
Published: September 2019

AbstractOver- and under-sedation are common in the ICU, and contribute to poor ICU outcomes including delirium. Behavioral assessments, such as Richmond Agitation-Sedation Scale (RASS) for monitoring levels of sedation and Confusion Assessment Method for the ICU (CAM-ICU) for detecting signs of delirium, are often used. As an alternative, brain monitoring with electroencephalography (EEG) has been proposed in the operating room, but is challenging to implement in ICU due to the differences between critical illness and elective surgery, as well as the duration of sedation. Here we present a deep learning model based on a combination of convolutional and recurrent neural networks that automatically tracks both the level of consciousness and delirium using frontal EEG signals in the ICU. For level of consciousness, the system achieves a median accuracy of 70% when allowing prediction to be within one RASS level difference across all patients, which is comparable or higher than the median technician–nurse agreement at 59%. For delirium, the system achieves an AUC of 0.80 with 69% sensitivity and 83% specificity at the optimal operating point. The results show it is feasible to continuously track level of consciousness and delirium in the ICU.
Circ-0000284 arouses malignant phenotype of cholangiocarcinoma cells and regulates the biological functions of peripheral cells through cellular communication
Authors: Wang Shuming , Hu Yilin , Lv Xiurui , Li Bin , Gu Dianhua , Li Yang , Sun Yong , Su Yang 
Published: September 2019

Abstract
Circular RNAs (circRNAs) play a vital role in cancers. Accumulated evidences showed that the physiological condition of cells can be reflected by the circRNAs in the exosomes they secrete, and these exosomal circRNAs can be captured by the receptor cells, thereby inducing a series of cellular responses. We performed qRT-PCR to detect the expression level of circ-0000284 in cholangiocarcinoma cell lines, tissues and plasma exosomes. Then the direct interaction between circ-0000284 and miR-637 was investigated through dual-luciferase reporter assay, RNA binding protein immunoprecipitation (RIP) assay and Fluorescent in situ hybridization (FISH) assay. Subsequently, EdU (5-ethynyl-2′-deoxyuridine), migration, invasion assay, flow cytometry and nude mouse tumorigenicity assay were adopted to evaluate the effect of circ-0000284 on migration, invasion, proliferation and apoptosis of cholangiocarcinoma cells. Additionally, TEM was conducted to investigate the shape and size of exosomes from cholangiocarcioma and 293T cell lines. Circ-0000284 was evidently elevated in cholangiocarcinoma cell lines, tumor tissues and plasma exosomes. Meanwhile, the high expression of circ-0000284 enhanced the migration, invasion and proliferation abilities of cholangiocarcinoma cells in vivo and in vitro. Besides, the levels of circ-0000284 were increased in cholangiocarcinoma cells and exosomes from them. Moreover, exosomes from cholangiocarcinoma cells enhanced circ-0000284 expression and stimulated migration and proliferation of the surrounding normal cells. Our findings suggest that on the one hand circ-0000284 functions as a competitive endogenous RNA to promote cholangiocarcinoma progression, and on the other hand, circ-0000284 can be directly transferred from cholangiocarcinoma cells to surrounding normal cells via exosomes and in this way regulate the biological functions of surrounding normal cells.
Die neue S2k Leitlinie: Medizinische Kompressionstherapie der Extremitäten mit Medizinischem Kompressionsstrumpf (MKS), Phlebologischem Kompressionsverband (PKV) und Medizinischen adaptiven Kompressionssystemen (MAK)
Authors: Stücker Markus , Rabe Eberhard 
Published: September 2019

ZusammenfassungDie neue Leitlinie zur Medizinischen Kompressionstherapie geht erstmalig zusammenfassend auf die unterschiedlichen Optionen der phlebologischen Kompressionstherapie ein. Dabei ordnet sie den PKV und die MAK primär der Entstauungsphase zu, MKS der Erhaltungsphase. Der Einsatz flach gestrickter MKS wird nicht einer bestimmten Diagnose, sondern bestimmten Befunden des Patienten zugeschrieben. Dabei ermöglicht die höhere Stiffness den Einsatz bei therapieresistenten Ödemen, die höhere Biegesteifigkeit bei Hautfalten und die Möglichkeit Maschen bei Flachstrickware individuell auf- oder abzunehmen, den Einsatz bei außergewöhnlichen Kaliberunterschieden der Beine. Zur Verbesserung der Adhärenz sollen bei MKS möglichst niedrige Kompressionsklassen verwendet werden. Beim PKV sind viele Aspekte zu berücksichtigen, woraus die Beschränkung des PKV auf die Entstauungsphase in dieser Leitlinie zurückzuführen ist. Stärker als bisher wird als Ziel der Kompressionstherapie die Verbesserung der Lebensqualität der Patienten hervorgehoben.
Cytotoxic Effects of Ferula Latisecta on Human Glioma U87 Cells
Authors: Jalili-Nik Mohammad , Sabri Hamed , Zamiri Ehsan , Soukhtanloo Mohammad , Roshan Mostafa Karimi , Hosseini Azar , Mollazadeh Hamid , Vahedi Mohammad Mahdi , Afshari Amir R. , Mousavi Seyed Hadi 
Published: September 2019

AbstractGlioblastoma multiforme (GBM) is the fatal type of astrocytic tumors with a
survival rate of 12 months. The present study, for the first time, evaluated the
cytotoxic impacts of Ferula latisecta (F. latisecta)
hydroalcoholic extract on U87 GBM cell line. The MTT assay measured the cellular
toxicity following 24- and 48 h treatment with various doses of F.
latisecta (0–800 μg/mL). Apoptosis was
evaluated by an Annexin V/propidium iodide (PI) staining 24 h
after treatment by F. latisecta. Moreover, to determine the cellular
metastasis of U87 cells, we used a gelatin zymography assay (matrix
metalloproteinase [MMP]-2/-9 enzymatic activity). The outcomes showed
that F. latisecta mitigated the viability of U87 cells in a
concentration- and time-dependent manner with IC50 values of 145.3
and 192.3 μg/mL obtained for 24- and 48 h
treatments, respectively. F. latisecta induced apoptosis in a
concentration-dependent manner after 24 h. Also, MMP-9 activity was
significantly decreased following 24 h after treatment
concentration-dependently with no change in MMP-2 enzymatic activity. This study
showed that F. latisecta induced cytotoxicity and apoptosis, and
mitigated metastasis of U87 GBM cells. Hence, F. latisecta could be
beneficial as a promising natural herb against GBM after further studies.
Epistemic governance in local policy debates: The case of entitlement to early childhood education and care in Finland
Authors: Paananen Maiju , Alasuutari Maarit , Karila Kirsti , Siippainen Anna 
Published: September 2019

ABSTRACT
In Finland, children below school age have enjoyed the right to attend subsidised full-time early childhood education and care (ECEC). However, the attendance rate in Finland is low in comparison to other Nordic countries. Furthermore, the entitlement was restricted to 20 h per week in 2016 unless the child’s parents work or study full-time or unless it is believed that the child will benefit from full-time ECEC. The debates concerning restrictions in ECEC entitlement in three municipal councils serve as the data for this study. By using the framework of epistemic governance, we identify three differing constructions of the ECEC’s societal functions in the municipal policy debates. The similarities and differences between these constructions aid us to understand recent changes in ECEC policies. This case illustrates how focusing on epistemic governance on local-level policy debates opens interesting insights in policy changes more generally.
A scalable quantum computing platform using symmetric-top molecules
Authors: Yu Phelan , Cheuk Lawrence W , Kozyryev Ivan , Doyle John M 
Published: September 2019

Abstract
We propose a new scalable platform for quantum computing (QC)—an array of optically trapped symmetric-top molecules (STMs) of the alkaline earth monomethoxide (MOCH3) family. Individual STMs form qubits, and the system is readily scalable to 100–1000 qubits. STM qubits have desirable features for QC compared to atoms and diatomic molecules. The additional rotational degree of freedom about the symmetric-top axis gives rise to closely spaced opposite parity K-doublets that allow full alignment at low electric fields, and the hyperfine structure naturally provides magnetically insensitive states with switchable electric dipole moments. These features lead to much reduced requirements for electric field control, provide minimal sensitivity to environmental perturbations, and allow for 2-qubit interactions that can be switched on at will. We examine in detail the internal structure of STMs relevant to our proposed platform, taking into account the full effective molecular Hamiltonian including hyperfine interactions, and identify useable STM qubit states. We then examine the effects of the electric dipolar interaction in STMs, which not only guide the design of high-fidelity gates, but also elucidate the nature of dipolar exchange in STMs. Under realistic experimental parameters, we estimate that the proposed QC platform could yield gate errors at the 10−3 level, approaching that required for fault-tolerant QC.
Photon-number parity of heralded single photons from a Bragg-reflection waveguide reconstructed loss-tolerantly via moment generating function
Authors: Laiho K , Schmidt M , Suchomel H , Kamp M , Höfling S , Schneider C , Beyer J , Weihs G , Reitzenstein S 
Published: September 2019

Abstract
Due to their strict photon-number correlation, the twin beams produced in parametric down-conversion (PDC) work well for heralded state generation. Often, however, this state manipulation is distorted by the optical losses in the herald and by the higher photon-number contributions inevitable in the PDC process. In order to find feasible figures of merit for characterizing the heralded states, we investigate their normalized factorial moments of the photon number that can be accessed regardless of the optical losses in the detection. We then perform a measurement of the joint photon statistics of twin beams from a semiconductor Bragg-reflection waveguide with transition-edge sensors acting as photon-number-resolving detectors. We extract the photon-number parity of heralded single photons in a loss-tolerant fashion by utilizing the moment generating function. The photon-number parity is highly practicable in quantum state characterization, since it takes into account the complete photon-number content of the target state.
Information and contact geometric description of expectation variables exactly derived from master equations
Authors: Goto Shin-itiro , Hino Hideitsu 
Published: September 2019

Abstract
In this paper a class of dynamical systems describing expectation variables exactly derived from continuous-time master equations is introduced and studied from the viewpoint of differential geometry, where such master equations consist of a set of appropriately chosen Markov kernels. To geometrize such dynamical systems for expectation variables, information geometry is used for expressing equilibrium states, and contact geometry is used for nonequilibrium states. Here time-developments of the expectation variables are identified with contact Hamiltonian vector fields on a contact manifold. Also, it is shown that the convergence rate of this dynamical system is exponential. Duality emphasized in information geometry is also addressed throughout.
Super (a, d)-H-antimagic total labeling of edge corona product on cycle with path graph and cycle with cycle graph
Authors: Permata Sari Arum , Sri Martini Titin , Yugi Kurniawan Vika 
Published: September 2019

Abstract
A simple graph G = (V(G), E(G)) admits a H-covering, where H is subgraph of G, if every edge in E(G) belongs to a subgraph of G that is isomorphic to H. An (a, d)-H-antimagic total labeling of G is a bijective function

ξ
:
V
(
G
)
∪
E
(
G
)
→

{

1
,
2
,
…
,

|

V
(
G
)

|

+

|

E
(
G
)

|

}

, such that for all subgraphs H’ isomorphic to H, the H’ weights w(H’) = ∑
v∈V(H’) ξ(v) + ∑
e∈E(H’) ξ(e) constitute an arithmetic progression a, a + d, a + 2d, …, a + (k – 1)d where a and d are positive integers and k is the number of subgraphs of G isomorphic to H. Such a labeling is called super if the smallest possible labels appear on the vertices. This research has found super (a, d)-H-antimagic total labeling of edge corona product of cycle and path denoted by Cm
◊ Pn
with H is P
2 ◊ Pn
and super (a, d)-P
2 ◊ Cn
-antimagic total labeling of Cm
◊ Cn
.
On H-supermagic labeling of friendship edge corona product with path and sun edge corona product with path
Authors: Noviati T , Martini T S , Indriati D 
Published: September 2019

Abstract
Let G be a simple, finite, connected and undirected graph with vertex set V and edge set E. Graph G admits an H-covering if every edge in E belongs to a subgraph of G isomorphic to H. Graph G is H− magic if there is a total labeling

f
:
V
(
G
)
∪
E
(
G
)
→

{

1
,
2
,
…
,

|

V
(
G
)

|

+

|

E
(
G
)

|

}

, such that each subgraph H′ = (V′, E′) of G isomorphic to H and satisfying

f

(
H
′
)

def

=

∑

υ
∈
V
(
H
′
)

f
(
υ
)

+

∑

e
∈
E
(
H
′
)

f
(
e
)
=
m
(
f
)

where m(f) is a constant magic sum. Additionaly, G admits H− supermagic if f(V ) = {1, 2, …, |V(G)|}. The edge corona product between graph G
1 and G
2 is a graph obtained by taking one copy of G
1 and |E(G
1)| copies of G
2 and then joining two end − vertices of the ith
edge of G
1 to every vertex in ith
copy of G
2. This research provides C
3 ◊ Pn
-supermagic labeling on fn
◊ Pn
and P
3 ◊ Pn
-supermagic labeling on Sn
◊ Pn
.