bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Cost-Effectiveness of specialized Nursing Interventions for people with Parkinson’s Disease: the NICE-PD study protocol for a randomized controlled clinical trial
Authors: Radder Danique LM , Lennaerts Herma H , Vermeulen Hester , Asseldonk Thies van , Delnooz Cathérine CS , Hagen Rob H , Munneke Marten , Bloem Bastiaan R , de Vries Nienke M 
Published: April 2019

Abstract
Background

Current guidelines recommend that every person with Parkinson’s disease (PD) should have access to Parkinson’s Disease Nurse Specialist (PDNS) care. However, there is little scientific evidence on the cost-effectiveness of PDNS care. This hampers wider implementation, creates unequal access to care and possibly leads to avoidable disability and costs. Therefore, we aim to study the (cost-)effectiveness of specialized nursing care provided by a PDNS compared to usual care (without PDNS) for people with PD in all disease stages. To gain more insight into the deployed interventions and their effects, a pre-planned subgroup analysis will be performed based on disease duration (diagnosis <5, 5-10, or >10 years ago).

Methods

We will perform an 18-month, single-blind, randomized controlled clinical trial in eight community hospitals in the Netherlands. A total of 240 people with PD that have not been treated by a PDNS over the past two years will be included, independent of disease severity or duration. In each hospital, 30 patients will randomly be allocated in a 1:1 ratio to either care by a PDNS (who works according to a recent guideline on PDNS care) or usual care. We will use two co-primary outcomes: quality of life (measured with the Parkinson’s Disease Questionnaire-39) and motor symptoms (measured with the MDS-UPDRS part III). Secondary outcomes include non-motor symptoms, health-related quality of life, experienced quality of care, self-management, medication adherence, caregiver burden and coping skills. Data will be collected after 12 months and 18 months by a blinded researcher. A healthcare utilization and productivity loss questionnaire will be completed every 3 months.

Discussion

The results of this trial will have an immediate impact on the current care of people with PD. We hypothesize that, by offering more patients access to PDNS care, quality of life will increase. We also expect healthcare costs to remain equal, as increases in direct medical costs (funding additional nurses) will be offset by a reduced number of consultations with the general practitioner and neurologist. If these outcomes are reached, wide implementation of PDNS care is warranted.

Trial registration

ClinicalTrials.gov: NCT03830190. Registered February 5, 2019 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03830190.
Comparison of Pressure-Controlled Ventilation with Volume Guarantee and Volume-Controlled Ventilation mode in Patients under Laparoscopic Surgery: A Meta-Analysis of Randomized Controlled Trials
Authors: Li Xiaoxiao , Lv Xueli , Jiang Zhenfei , Nie Xinrui , Liu Su 
Published: April 2019

Abstract
Background：In traditional Volume-Controlled Ventilation (VCV) mode, the creation of pneumoperitoneum during laparoscopic surgery may lead to Ventilator-Associated Lung Injury (VALI). Pressure-Controlled Ventilation with Volume Guarantee (PCV-VG) mode ensures providing adequate oxygen supply to patients while reducing the risk of lung injury. Methods：Eligible randomized clinical trials (RCTs) were searched in Medline, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Sino Med, China National Knowledge Infrastructure (CNKI) and Wan-Fang MED without language restriction up to March 2019. The primary outcome of this meta-analysis was airway peak pressure (Ppeak) at 30, 60 or 90 mins after complete CO2 insufflation. This meta-analysis was followed the recommendations of the PRISMA statement. Results：Finally, 9 articles were included. The Ppeak in the PCV-VG group was lower than that in the VCV group, and the difference was statistically significant at 30mins [Mean Difference (MD)= -3.55, 95% Confidence Interval (CI)= -5.13 to -1.98, I2=83%], 60mins [MD= -5.76, 95%CI= -8.15-3.36, I2=93%], 90 mins [MD= -4.59, 95%CI= -5.43-3.74, I2=30%] after complete CO2 insufflation. Meanwhile, PCV-VG mode could effectively reduce airway mean pressure (Pmean) and improve dynamic compliance (Cdyn) of patients after complete CO2 insufflation in laparoscopic surgery compared to VCV mode. However, no significant difference was found in PetCO2, HR, MAP, PH, PaO2, and PaCO2 between the two-ventilation modes. Conclusions: PCV-VG mode are superior to VCV mode in providing adequate oxygenation at lower airway peak pressure and greater dynamic compliance in patients under laparoscopic surgery.
Description of Rotylenchus rhomboides n. sp. and a Belgian population of Rotylenchus buxophilus (Tylenchomorpha: Hoplolaimidae)
Authors: Nguyen Huu Tien , Trinh Quang Phap , Couvreur Marjolein , Singh Phougeishangbam Rolish , Decraemer Wilfrida , Bert Wim 
Published: April 2019

Abstract
During a survey in the Botanical garden of Ghent University, a new species Rotylenchus rhomboides n. sp. and a population of Rotylenchus buxophilus were found. Rotylenchus rhomboides n. sp. is characterized by the presence of a rhomboid-like widening of the mid-ridge of lateral field at the level of vulva, a feature previously unknown within the genus. The population of the new species, composed only by females, has a rounded labial region with 4 to 5 annuli, robust stylet (31–37 μm long), short dorsal esophageal gland (9–19 μm) overlap of the intestine, vulva located slightly posterior to mid-body, and hemispherical or rounded tail shape with large phasmids located 3 to 5 annuli anterior to the level of anus. The hierarchical cluster analysis based on morphological features indicated that the new species closely resembles R. corsicus, R. gracilidens, and R. rugatocuticulatus. The DNA analyses of the D2-D3 of 28S rDNA, ITS rDNA, and COI mtDNA sequences of Rotylenchus rhomboides n. sp. show a close relationship with R. buxophilus, R. goodeyi, R. laurentinus, R. pumilus, and R. incultus, all of which can also be differentiated from the new species by morphological features. The combination of morphological, morphometric, and molecular characteristics confirmed the new species and the first report of R. buxophilus on yam (Dioscorea tokoro) in Belgium.
Development of Single Nucleotide Polymorphism Markers for the Wheat Curl Mite Resistance Gene Cmc4
Authors: Zhao Jixin , Abdelsalam Nader R. , Khalaf Luaay , Chuang Wen‐Po , Zhao Lanfei , Smith C. Michael , Carver Brett , Bai Guihua 
Published: April 2019

ABSTRACTWheat curl mite (Aceria tosichella Keifer) is an important wheat (Triticum aestivum L. em. Thell.) pest in many wheat‐growing regions worldwide. Mite feeding damage not only directly affects wheat yield, but A. tosichella also transmits Wheat streak mosaic virus (WSMV). Wheat resistance to A. tosichella, therefore, helps control WSMV. OK05312 (PI 670019) is an advanced breeding line released from Oklahoma that shows a high level of A. tosichella resistance. To map the gene(s) conditioning wheat resistance to A. tosichella in OK05312, a genetic linkage map was constructed using single nucleotide polymorphism (SNP) markers derived from genotyping‐by‐sequencing (GBS) and a population of 186 recombinant inbred lines (RILs) from the cross ‘Jerry’ (PI 632433)/OK05312. Seedlings of both parents and the RIL population were infested by A. tosichella Biotype 1 in greenhouse experiments. One major quantitative trait locus was identified on the short arm of chromosome 6D, which corresponds to the previously reported gene Cmc4 for A. tosichella resistance. This gene explained up to 71% of the phenotypic variation and was delimited in a 1.7‐Mb (∼3.3‐cM) region by SNPs 370SNP7523 and 370SNP1639. We successfully converted 12 GBS‐SNPs into Kompetitive allele specific polymerase chain reaction (KASP) markers. Two of them tightly linked to Cmc4 were validated to be highly diagnostic in a US winter wheat population and can be used for marker‐assisted breeding for incorporation of Cmc4 into new wheat cultivars.
Wykorzystanie publikacji francuskich przy realizacji nagrobków na cmentarzach Warszawy w latach 1840-1860. Wzornik Josepha Marty'ego
Authors: Wiraszka Marta 
Published: April 2019

The article in question is a continuity of the subject brought up in the magazine ”Artifex Novus” published in October 2017. Its first part referred to the tombstones created on the ground of works printed in Paris in 1832 on the pages of two illustrated magazines whose authors were Ferdinando Quaglia and Louis-Marie Normand respectively. The other part was dedicated to the pattern book by Joseph Mart and the objects performed on its ground. Collected pieces of information enable us to conclude that between 1840 and 1860 on the premises of the necropoleis of Warsaw a minimum of 20 tombstones, with the forms following those published in the above mentioned magazines, were raised. The vast majority of preserved examples, as many as 14, can be found on the premises of the Powązki Cemetery, another three were discovered at the Evangelical Augsburg Cemetery and two at the Evangelical Reformed Cemetery. Moreover, it has been stated that such tombstones happen to be funded on the premises of necropolies located outside the boundaries of the capital e.g. in Lublin, Pułtusk, Radom etc. Even though none of the tombstones was signed, it can be concluded the center of production and distribution was Warsaw and the stonework manufactures in operation in the city. Among others, attention was drawn to two manufactures: the one of Jan Ścisłowski (1805-1847) located at 6 Powązkowska Street, inherited and led by his two sons-in-law: Antoni Messing (1821-1867) and Jan Bernard Sikorski (1832-1906), and the other belonging to the Mantzl family, Jan Józef senior – the father (1806-1875) and Józef Jan junior, – the son (1834-1906), the manufacture previously located at 19 Chłodna Street. The tombstones funded and co-funded by relatives and friends were copings to graves of the wealthy, high officials, militaries, real estate and factory owners, entrepreneurs, merchants as well as craftsmen. The offer of the stonework manufactures in Warsaw reflected the taste of the elite, in the vast majority of Catholics of aristocratic descendance willing to show pro-French likeness and respect to the culture in question, having it as more sophisticated than the one dating back to the monarchy of Louis the XIV, and in particular, forming bonds with the empire of Napoleon Bonaparte the I.
1,4-Dihydropyridine: A Dependable Heterocyclic Ring with the Promising and the Most Anticipable Therapeutic Effects
Authors: Mishra Abhinav Prasoon , Bajpai Ankit , Rai Awani Kumar 
Published: April 2019

:
Nowadays, heterocyclic compounds act as a scaffold and are the backbone of medicinal
chemistry. Among all of the heterocyclic scaffolds, 1,4-Dihydropyridine (1,4-DHP) is one of the most
important heterocyclic rings that possess prominent therapeutic effects in a very versatile manner and
plays an important role in synthetic, medicinal, and bioorganic chemistry. The main aim of the study is
to review and encompass relevant studies related to 1,4-DHP and excellent therapeutic benefits of its
derivatives. An extensive review of Pubmed-Medline, Embase and Lancet’s published articles was
done to find all relevant studies on the activity of 1,4-DHP and its derivatives. 1,4-DHP is a potent
Voltage-Gated Calcium Channel (VGCC) antagonist derivative which acts as an anti-hypertensive, anti-
anginal, anti-tumor, anti-inflammatory, anti-tubercular, anti-cancer, anti-hyperplasia, anti-mutagenic,
anti-dyslipidemic, and anti-ulcer agent. From the inferences of the study, it can be concluded that the
basic nucleus, 1,4-DHP which is a voltage-gated calcium ion channel blocker, acts as a base for its derivatives
that possess different important therapeutic effects. There is a need of further research of this
basic nucleus as it is a multifunctional moiety, on which addition of different groups can yield a better
drug for its other activities such as anti-convulsant, anti-oxidant, anti-mutagenic, and anti-microbial.
This review would be significant for further researches in the development of several kinds of drugs by
representing successful matrix for the medicinal agents.
Inhibition of Experimental Age-Related Macular Degeneration by ZQMT in Mice
Authors: Yang Liu , Meng Huan , Luo Dan , Deng Tingting , Miao Li , Zou Bin , Ge Xiaofei , Hu Xiao , Liu Yu , Li Xifang , Deng Xiuli , Guo Shixin , Liang Juanran , Chen Tingting , Wen Xiaofeng , Li Jing Jing , Wei Lai , Jin Ming 
Published: April 2019

Background:
Age-related macular degeneration (AMD) is a progressive and
irreversible eye disease. The anti-vascular endothelial growth factor (VEGF) therapy has
revolutionized the treatment of neovascular AMD. However, the expense for such
treatment is quite high.

Methods:
We used a traditional Chinese medicine ZQMT as an alternative therapeutic
regimen for AMD. We employed two in vivo animal models mimicking dry and wet AMD
respectively to assess the therapeutic efficacy of ZQMT on treating AMD-related
retinopathy. AMD-related retinopathy in Crb1rd8 mice was evaluated from week 1 to 8 by
fundus photography. Laser-induced choroidal neovascularization (CNV) was evaluated
by fluorescein angiography and histopathology.

Results:
ZQMT increased CX3CR1 expression in murine CD4+ T cells either cultured in
vitro or directly isolated from animals treated with ZQMT. We also performed both in
vitro and in vivo studies to confirm that ZQMT has no apparent toxic effects. ZQMT
alleviated AMD-related retinopathy in both Crb1rd8 and CNV models. Depletion of CCL2
and CX3CR1 in Crb1rd8 mice abolished the efficacy of ZQMT, suggesting that CCL2
and/or CX3CR1 may underlie the mechanisms of ZQMT in treating AMD-related
retinopathy in mice.

Conclusion:
In summary, our study supports the protective roles of a traditional
Chinese medicine ZQMT in AMD.
Understanding Family Connections and Help Seeking Behavior in Chinese American Immigrant Adults who Attempt Suicide
Authors: Wong Rose , Hou Dong Li , Wong-Kim Evaon 
Published: April 2019

Aim:
This study explores the influence of beliefs, values and norms in Chinese family culture as they relate to
attitudes and beliefs about mental health and mental health services. It examines family and acculturative stressors
occurring in the immigrant’s social context on attitudes about suicidal distress and help-seeking behaviors, and focuses on
appropriate forms of services for suicidal behaviors among adult immigrants experiencing suicidal behaviors.

Methods:
The study design is descriptive, using a qualitative approach. Six Chinese American immigrant adults who had
attempted suicide participated in semi-structured interviews in Mandarin or Cantonese. The content was analyzed using a
constant comparative approach.

Results:
Study participants exhibited various reactions to suicidal distress, attitudes about needing help and usefulness and
relevance of existing intervention strategies and services that reflected influences of Chinese family culture. Interactions
with family members negatively impacted study participants’ attitudes about using services and hindered pathways to
care. Acculturative stressors, along with weak family ties and the absence of strong community networks exacerbated the
strategies for effective services.

Conclusion:
This study raises the question of the efficacy of several Western-culture based service delivery models on
help-seeking behaviors on such populations. Furthermore, the study discusses ethnic sensitive approaches with core roles
for family, peers and community for supporting those at risk of attempting suicide and linking them to appropriate
community-based services.
Buenas prácticas en el área de idiomas como herramienta para el logro de competencias
Authors: Helguera Colonia M.E. Marisela 
Published: April 2019

<p>La educación a distancia está en continuo crecimiento y los miembros de este proceso virtual constantemente están en búsqueda de estrategias que favorezcan el proceso enseñanza aprendizaje. En el presente artículo se aborda el empleo de la buena práctica como medio para fomentar las competencias en el área de idiomas del Bachillerato en Línea de la Universidad Autónoma de Yucatán. </p><p>Asimismo, se detalla la metodología utilizada para la realización del análisis, los resultados y las conclusiones del mismo.</p>
La introducción de asesores en el bachillerato de modalidad mixta (BGAI)
Authors: Pérez Márquez Delia Patricia 
Published: April 2019

<p>El Bachillerato General por Áreas Interdisciplinarias (BGAI) de la Universidad de Guadalajara se oferta, en modalidad mixta, en más de 25 escuelas en el estado de Jalisco, lo que implica una amplia plantilla de docentes que continuamente se incorporan al programa. </p><p>El cambio de paradigma en una educación formal que emplea el aula física como espacio combinado con el aula virtual, enfatiza la importancia de un programa de formación para aquellos interesados en fungir como asesores dentro de la modalidad; en dicho proceso, el primer acercamiento lo constituye el “Curso de Inducción para Asesores” que además de aproximación al funcionamiento y la experiencia de la modalidad mixta, su sustento teórico y normativo, pretende conformar asesores capaces de mostrar una presencia sólida dentro del aula (ya sea física o virtual) y de dominar las tecnologías necesarias para el logro de las competencias en sus estudiantes.</p>
O fazer cientí­fico na produção textual de Muraro: transgressão e militância
Authors: Gomes Tânia Maria Oliveira 
Published: April 2019

Neste trabalho, pretende-se efetuar uma célere análise discursiva de alguns excertos da obra Sexualidade da mulher brasileira: corpo e classe social no Brasil (MURARO, 1983). Perfilhando a análise do discurso a estudos que se debruçam sobre os gêneros textuais, tais como aqueles desenvolvidos por Bakhtin (2003), Maingueneau (2004), Lara (2008), Mari e Silveira (2004) e Rastier (1998), objetiva-se examinar como as produções genéricas, das quais Muraro (1983) se vale, contribuem para a construção de sentidos, na leitura e na escrita, de textos cientí­ficos. Salienta-se que as respostas preliminares í s questões elaboradas, neste artigo, parecem apontar para um fazer cientí­fico pautado no vanguardismo e no engajamento social. Como conclusão principal, atesta-se a importância do legado de Muraro (1983), imortal, antes e depois do seu falecimento, ocorrido este ano.
Notí­cia e editorial: procedimentos de análise linguí­stica e sua relação com a construção de sentido nos gêneros jornalí­sticos
Authors: Segato Maiara Cristina 
Published: April 2019

O ensino de lí­ngua portuguesa, pautado nos gêneros discursivos, passou a ter como objetivo conceber a prática pedagógica em três eixos interligados e ligados í s práticas sociais, ou seja, a leitura, a análise linguí­stica e a produção de texto oral e escrito. A partir do quadro teórico da análise dialógica do discurso, o qual se coaduna aos objetivos do ensino de Lí­ngua Portuguesa preconizados nas propostas pedagógico-curriculares nacionais, este artigo descreve uma possibilidade de prática de análise linguí­stica, que visa a contribuir com o desenvolvimento das competências linguí­sticas e discursivas dos alunos, numa visada reflexiva sobre o estilo verbal concretizado nos gêneros jornalí­sticos notí­cia e editorial.
A constituição teórica, metodológica e prática sobre revisão e reescrita na formação docente inicial-PIBID
Authors: Beloti Adriana , Menegassi Renilson José 
Published: April 2019

Neste trabalho, tratamos sobre a relação entre a formação teórico-metodológica e a prática de professores em formação docente inicial participantes do PIBID, a fim de compreender de quais conceitos relativos í s etapas de revisão e de reescrita esses sujeitos apropriam-se e como refletem-se em suas atuações no momento de fazer intervenções em textos de estudantes do Ensino Fundamental. Para tanto, sustentamo-nos na perspectiva enunciativo discursiva e na concepção dialógica de linguagem, oriunda do Cí­rculo de Bakhtin (BAKHTIN, 2003; BAKHTIN/VOLOCHÍNOV, 2006); no conceito de escrita como trabalho (FIAD; MAYRINK-SABINSON, 1991; MENEGASSI, 2016); nas reflexões sobre revisão e reescrita, a partir de estudos de Menegassi (1998) e Ruiz (2010). A metodologia advém do aporte da Linguí­stica Aplicada (MOITA-LOPES, 2006) e da pesquisa-ação (THIOLLENT, 2005; TRIPP, 2005), já que possibilitamos a formação teórico-metodológica e a relacionamos à análise da prática de revisão e reescrita de textos, em situação de ensino. Nossas análises consideram, portanto: a) a formação proporcionada pelo PIBID; b) a atuação dos professores no processo de revisão e reescrita. Dos registros da pesquisa, observamos como os conceitos de revisão e de reescrita são apropriados pelos professores e revelados em suas atuações no processo de produção textual no Ensino Fundamental, chegando à conclusão de que os professores apropriam-se dos seguintes conceitos: a) revisão e reescrita como etapas processuais, recursivas e dialógicas; b) vários tipos de correção e suas respectivas funções; c) reescrita como etapa que se materializa por meio das operações linguí­stico-discursivas.
Initial Evidence of U.S. Audit Partner Identification in Form AP Shows Limited Impact on Audit Quality
Authors: Cunningham Lauren M. , Stein Sarah E. , Wright Nicole S. 
Published: April 2019

SUMMARY
This article summarizes a study (Cunningham, Li, Stein, and Wright 2019) in which we examine the initial impact of Form AP partner disclosure on audit quality. One difficulty with studying the effect of Form AP is that general time trends likely occurred even in the absence of partner disclosure. Our study addresses this concern by comparing two groups of audits: those experiencing partner name disclosure for the first time (treatment) and those not subject to the same shock (control). If Form AP was effective at driving immediate improvement in audit quality, any change for the treatment group should be greater than the control group. We conclude that audit quality appears to improve year-over-year; however, significant differences do not exist between these two groups in most of our tests, suggesting that partner disclosure does not explain these general trends. Further research is necessary to evaluate other potential impacts of Form AP.
Reengineering the Audit with Blockchain and Smart Contracts
Authors: Rozario Andrea M. , Thomas Chanta 
Published: April 2019

ABSTRACT
Blockchain and smart contracts are evolving business practices by enhancing efficiencies and transparency in the value chain. The fusion of these innovations is also likely to transform auditing by automating workflows but more importantly, by enhancing audit effectiveness and reporting. This paper envisions the future financial statement audit by proposing an external audit blockchain that supports smart audit procedures. The external audit blockchain has the potential to improve audit quality and narrow the expectation gap between auditors, financial statement users, and regulatory bodies.