bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased creative thinking in narcolepsy
Authors: Lacaux Célia , Izabelle Charlotte , Santantonio Giulio , De Villèle Laure , Frain Johanna , Lubart Todd , Pizza Fabio , Plazzi Giuseppe , Arnulf Isabelle , Oudiette Delphine 
Published: May 2019

Abstract
Some studies suggest a link between creativity and rapid eye movement sleep. Narcolepsy is characterized by falling asleep directly into rapid eye movement sleep, states of dissociated wakefulness and rapid eye movement sleep (cataplexy, hypnagogic hallucinations, sleep paralysis, rapid eye movement sleep behaviour disorder and lucid dreaming) and a high dream recall frequency. Lucid dreaming (the awareness of dreaming while dreaming) has been correlated with creativity. Given their life-long privileged access to rapid eye movement sleep and dreams, we hypothesized that subjects with narcolepsy may have developed high creative abilities. To test this assumption, 185 subjects with narcolepsy and 126 healthy controls were evaluated for their level of creativity with two questionnaires, the Test of Creative Profile and the Creativity Achievement Questionnaire. Creativity was also objectively tested in 30 controls and 30 subjects with narcolepsy using the Evaluation of Potential Creativity test battery, which measures divergent and convergent modes of creative thinking in the graphic and verbal domains, using concrete and abstract problems. Subjects with narcolepsy obtained higher scores than controls on the Test of Creative Profile (mean ± standard deviation: 58.9 ± 9.6 versus 55.1 ± 10, P = 0.001), in the three creative profiles (Innovative, Imaginative and Researcher) and on the Creative Achievement Questionnaire (10.4 ± 25.7 versus 6.4 ± 7.6, P = 0.047). They also performed better than controls on the objective test of creative performance (4.3 ± 1.5 versus 3.7 ± 1.4; P = 0.009). Most symptoms of narcolepsy (including sleepiness, hypnagogic hallucinations, sleep paralysis, lucid dreaming, and rapid eye movement sleep behaviour disorder, but not cataplexy) were associated with higher scores on the Test of Creative Profile. These results highlight a higher creative potential in subjects with narcolepsy and further support a role of rapid eye movement sleep in creativity.
The prognosis of functional limb weakness: a 14-year case-control study
Authors: Gelauff Jeannette M , Carson Alan , Ludwig Lea , Tijssen Marina A J , Stone Jon 
Published: May 2019

Abstract
Reliable data on the prognosis of functional motor disorder are scarce, as existing studies of the prognosis of functional motor disorder are nearly all retrospective, small and uncontrolled. In this study we used a prospectively recruited, controlled cohort design to assess misdiagnosis, mortality and symptomatic and health outcome in patients with functional limb weakness compared to neurological disease and healthy control subjects. We also carried out an exploratory analysis for baseline factors predicting outcome. One hundred and seven patients with functional limb weakness, 46 neurological and 38 healthy control subjects from our previously studied prospective cohort were traced for follow-up after an average of 14 years. Misdiagnosis was determined in a consensus meeting using information from records, patients and their GPs. Numbers and causes of death were collected via death certificates. Outcome of limb weakness, physical and psychiatric symptoms, disability/quality of life and illness perception were recorded with self-rated questionnaires. Outcome measures were compared within and between groups. Seventy-six patients (71%) with functional limb weakness, 31 (67%) neurological and 23 (61%) healthy controls were included in follow-up. Misdiagnosis was found in one patient in the functional limb weakness group (1%) and in one neurological control (2%). Eleven patients with functional limb weakness, eight neurological control subjects and one healthy control subject had died. Weakness had completely remitted in 20% of patients in the functional limb weakness group and in 18% of the neurological controls (P = 0.785) and improved in a larger proportion of functional limb weakness patients (P = 0.011). Outcomes were comparable between patient groups, and worse than the healthy control group. No baseline factors were independent predictors of outcome, although somatization disorder, general health, pain and total symptoms at baseline were univariably correlated to outcome. This study is the largest and longest follow-up study of functional limb weakness. Misdiagnosis in functional limb weakness is rare after long-term follow-up. The disorder is associated with a higher mortality rate than expected, and symptoms are persistent and disabling. It appears difficult to predict outcome based on common baseline variables. These data should help inform clinicians to provide a more realistic outlook of the outcome and emphasize the importance of active and targeted therapy.
Attribute-Based Information Flow Control
Authors: Han Jinguang , Bei Maoxuan , Chen Liqun , Xiang Yang , Cao Jie , Guo Fuchun , Meng Weizhi 
Published: May 2019

Abstract
Information flow control (IFC) regulates where information is permitted to travel within information systems. To enforce IFC, access control encryption (ACE) was proposed to support both the no read-up rule and the no write-down rule. There are some problems in existing schemes. First, the communication cost is linear with the number of receivers. Second, senders are not authenticated, namely an unauthorized sender can send a message to a receiver. To reduce communication cost and implement sender authentication, we propose an attribute-based IFC (ABIFC) scheme by introducing attribute-based systems into IFC. Our ABIFC scheme captures the following features: (i) flexible IFC policies are defined over a universal set of descriptive attributes; (ii) both the no read-up rule and the no write-down rule are supported; (iii) the communication cost is linear with the number of required attributes, instead of receivers; (iv) receivers can outsource heavy computation to a server without compromising data confidentiality; (v) authorized senders can control release their attributes when sending messages to receivers. To the best of our knowledge, it is the first IFC scheme where flexible policies are defined over descriptive attributes and outsourced computation is supported.
The impacts of warming and hypoxia on the performance of an obligate ram ventilator
Authors: Crear Daniel P , Brill Rich W , Bushnell Peter G , Latour Robert J , Schwieterman Gail D , Steffen Rachel M , Weng Kevin C 
Published: May 2019

Abstract
Climate change is causing the warming and deoxygenation of coastal habitats like Chesapeake Bay that serve as important nursery habitats for many marine fish species. As conditions continue to change, it is important to understand how these changes impact individual species’ behavioral and metabolic performance. The sandbar shark (Carcharhinus plumbeus) is an obligate ram-ventilating apex predator whose juveniles use Chesapeake Bay as a nursery ground up to 10 years of age. The objective of this study was to measure juvenile sandbar shark metabolic and behavioral performance as a proxy for overall performance (i.e. fitness or success) when exposed to warm and hypoxic water. Juvenile sandbar sharks (79.5–113.5 cm total length) were collected from an estuary along the eastern shore of Virginia and returned to lab where they were fitted with an accelerometer, placed in a respirometer and exposed to varying temperatures and oxygen levels. Juvenile sandbar shark overall performance declined substantially at 32°C or when dissolved oxygen concentration was reduced below 3.5 mg l−1 (51% oxygen saturation between 24–32°C). As the extent of warm hypoxic water increases in Chesapeake Bay, we expect that the available sandbar shark nursery habitat will be reduced, which may negatively impact the population of sandbar sharks in the western Atlantic as well as the overall health of the ecosystem within Chesapeake Bay.
A mathematical framework for determining the stability of steady states of reaction–diffusion equations with periodic source terms
Authors: Ó Náraigh Lennon , Ee Pang Khang 
Published: May 2019

Abstract
We develop a mathematical framework for determining the stability of steady states of generic nonlinear reaction–diffusion equations with periodic source terms in one spatial dimension. We formulate an a priori condition for the stability of such steady states, which relies only on the properties of the steady state itself. The mathematical framework is based on Bloch’s theorem and Poincaré’s inequality for mean-zero periodic functions. Our framework can be used for stability analysis to determine the regions in an appropriate parameter space for which steady-state solutions are stable.
Ergot alkaloid exposure during gestation alters: 3. Fetal growth, muscle fiber development, and miRNA transcriptome1
Authors: Greene Maslyn A , Britt Jessica L , Powell Rhonda R , Feltus F Alex , Bridges William C , Bruce Terri , Klotz James L , Miller Markus F , Duckett Susan K 
Published: May 2019

Abstract
The objective of this study was to assess how exposure to ergot alkaloids during 2 stages of gestation alters fetal growth, muscle fiber formation, and miRNA expression. Pregnant ewes (n = 36; BW = 83.26 ± 8.14 kg; 4/group; 9 groups) were used in a 2 × 2 factorial arrangement with 2 tall fescue seed treatments [endophyte-infected (E+) vs. endophyte-free (E−)] fed during 2 stages of gestation (MID, days 35 to 85 vs. LATE, days 86 to 133), which created 4 possible treatments (E−/E−, E+/E−, E−/E+, or E+/E+). Ewes were individually fed a total mixed ration containing E+ or E− fescue seed according to treatment assignment. Terminal surgeries were conducted on day 133 of gestation for the collection of fetal measurements and muscle samples. Data were analyzed as a 2 × 2 factorial with fescue treatment, stage of gestation, and 2-way interaction as fixed effects. Fetuses exposed to E+ seed during LATE gestation had reduced (P = 0.0020) fetal BW by 10% compared with E− fetuses; however, fetal body weight did not differ (P = 0.41) with E+ exposure during MID gestation. Fetuses from ewes fed E+ seed during MID and LATE gestation tended to have smaller (P = 0.058) kidney weights compared with E− fetuses. Liver weight was larger (P = 0.0069) in fetuses fed E− during LATE gestation compared with E+. Fetal brain weight did not differ by fescue treatment fed during MID (P = 0.36) or LATE (P = 0.40) gestation. The percentage of brain to empty body weight (EBW) was greater (P = 0.0048) in fetuses from ewes fed E+ fescue seed during LATE gestation, which is indicative of intrauterine growth restriction (IUGR). Primary muscle fiber number was lower (P = 0.0005) in semitendinosus (STN) of fetuses exposed to E+ during MID and/or LATE gestation compared with E−/E−. miRNA sequencing showed differential expression (P < 0.010) of 6 novel miRNAs including bta-miR-652_R+1, mdo-miR-22-3p, bta-miR-1277_R-1, ppy-miR-133a_L+1_1ss5TG, hsa-miR-129-1-3p, and ssc-miR-615 in fetal STN muscle. These miRNA are associated with glucose transport, insulin signaling, intracellular ATP, hypertension, or adipogenesis. This work supports the hypothesis that E+ tall fescue seed fed during late gestation reduces fetal weight and causes asymmetrical growth, which is indicative of IUGR. Changes in primary fiber number and miRNA of STN indicate that exposure to E+ fescue fed during MID and LATE gestation alters fetal muscle development that may affect postnatal muscle growth and meat quality.
An updated checklist and key to the Zambian species of freshwater crabs, with the description of a new species of Potamonautes MacLeay, 1838 (Brachyura: Potamoidea: Potamonautidae)
Authors: Cumberlidge Neil , Fastiggi Clare , Clark Paul F 
Published: May 2019

AbstractA new species of the freshwater crab genus PotamonautesMacLeay, 1838 from Mporokoso, northern Zambia, southern Africa is described. Potamonautes caputanatisn. sp. is morphologically distinct from other species of this genus found in Zambia and its neighboring countries. The new species is recognised by a unique combination of morphological characters of the carapace, thoracic sternum, major cheliped, and adult male first gonopod. Illustrations of P. caputanatisn. sp. are provided and differences with congeners found elsewhere in Zambia and southern Africa are discussed. The addition of P. caputanatis n. sp. raises the number of species of freshwater crabs known to occur in Zambia to eleven. An updated checklist and key are provided to the Zambian species of freshwater crabs.
Setal morphology of grooming appendages in blue crabs Callinectes sapidus Rathbun, 1896 and stone crabs Menippe mercenaria (Say, 1818) (Decapoda: Brachyura: Portunidae, Menippidae)
Authors: Wortham Jen L , Pascual Stephanie 
Published: May 2019

AbstractRespiration, sensory input, movement, and molting rely on crustacean body regions being free of fouling. While the grooming appendages of shrimps have been described, few studies have documented the functional morphology of grooming appendages in brachyuran crabs. Because shrimps and brachyurans have very different body morphology and grooming behaviors, their grooming setae may vary. The morphology of grooming appendages of blue (Callinectes sapidusRathbun, 1896) and stone (Menippe mercenaria (Say, 1818)) crabs were investigated to gain better insight into their efficiencies in decreasing fouling. Callinectes sapidus is an active swimmer, migrates through currents across estuaries, spends less time grooming, and is exposed to more environmental variants in contrast to M. mercenaria, which has a lower activity level and spends more time grooming. To compensate for this higher activity level and lower grooming time budget, C. sapidus was predicted to have more setal types on its grooming appendages as compared to M. mercenaria. Thirteen different body appendages/regions involved in grooming are described in both species by using scanning electron and light microscopy. We documented the morphology, presence or absence of setal patches, and types of setae in 104 different grooming appendages and groomed body regions. Of 25 types of setae, nine are unique to C. sapidus, rejecting the hypothesis that C. sapidus have more diverse grooming setae. Menippe mercenaria has denser setal patches and less fouling than C. sapidus. Nine new setal types are described. Fouling, setal diversities, and functions that correspond to grooming behaviors are discussed.
Disentangling the complexity and diversity of crosstalk between sulfur and other mineral nutrients in cultivated plants
Authors: Courbet Galatéa , Gallardo Karine , Vigani Gianpiero , Brunel-Muguet Sophie , Trouverie Jacques , Salon Christophe , Ourry Alain 
Published: May 2019

AbstractA complete understanding of ionome homeostasis requires a thorough investigation of the dynamics of the nutrient networks in plants. This review focuses on the complexity of interactions occurring between S and other nutrients, and these are addressed at the level of the whole plant, the individual tissues, and the cellular compartments. With regards to macronutrients, S deficiency mainly acts by reducing plant growth, which in turn restricts the root uptake of, for example, N, K, and Mg. Conversely, deficiencies in N, K, or Mg reduce uptake of S. TOR (target of rapamycin) protein kinase, whose involvement in the co-regulation of C/N and S metabolism has recently been unravelled, provides a clue to understanding the links between S and plant growth. In legumes, the original crosstalk between N and S can be found at the level of nodules, which show high requirements for S, and hence specifically express a number of sulfate transporters. With regards to micronutrients, except for Fe, their uptake can be increased under S deficiency through various mechanisms. One of these results from the broad specificity of root sulfate transporters that are up-regulated during S deficiency, which can also take up some molybdate and selenate. A second mechanism is linked to the large accumulation of sulfate in the leaf vacuoles, with its reduced osmotic contribution under S deficiency being compensated for by an increase in Cl uptake and accumulation. A third group of broader mechanisms that can explain at least some of the interactions between S and micronutrients concerns metabolic networks where several nutrients are essential, such as the synthesis of the Mo co-factor needed by some essential enzymes, which requires S, Fe, Zn and Cu for its synthesis, and the synthesis and regulation of Fe-S clusters. Finally, we briefly review recent developments in the modelling of S responses in crops (allocation amongst plant parts and distribution of mineral versus organic forms) in order to provide perspectives on prediction-based approaches that take into account the interactions with other minerals such as N.
Gene pyramids and the balancing act of keeping pests at bay
Authors: MacIntosh Gustavo C 
Published: May 2019

This article comments on:
Kamphuis LG, Klingler JP, Jacques S, Gao L-l, Edwards OR, Singh KB. 2019. Additive and epistatic interactions between AKR and AIN loci conferring bluegreen aphid resistance and hypersensitivity in Medicago truncatula. Journal of Experimental Botany 70, 4887-4902.
Love and Money in The Informal Empire: The British in Argentina, 1830–1930*
Authors: Cohen Deborah 
Published: May 2019

Abstract
Debates about Britain s ‘informal empire’ range from how it ought to be defined to whether it even really existed. But for all the heat these arguments have generated, we still know very little about what the people at the heart of British-owned enterprises thought they were doing in regions outside formal imperial control but where British capital and markets proved crucial. Drawing upon a recent deposit in Argentina of a substantial set of Anglo‐Argentine familial and business records, this article investigates British capitalism on the periphery. Anglo‐Argentines, even those whose families made their living from the cross-Atlantic trade for a century or more, did not think about their enterprises as building territory or extending Britain’s influence in the world. Money-making was their aim and their loyalties did not extend much beyond their own front door. There is a crucial — but often overlooked — distinction to be made here between national identity and economic interest. Just as Britain’s greater glory took a back seat to commercial success, so too did meeting the material and emotional needs of family members take precedence over money‐making. They prioritized family harmony over profits and stability over the possibility of expansion.
Physical activity goals among patients in a primary care setting
Authors: Dodge Tonya , Joshi Deepti , Abaalkhail Saud , Moore Brad 
Published: May 2019

Abstract
One approach to increasing physical activity (PA) among adults is to develop interventions targeting PA goals that could be implemented in the primary care setting. However, there is little understanding of the types of goals that individuals bring with them into the primary care setting, which is a necessary first step in building interventions. There were three objectives of the study. One was to identify the types of PA goals held by primary care patients. Another was to examine whether there were racial differences among types of PA goals held by primary care patients. A final objective was to examine the relationship between PA goals and PA behaviors (e.g., meet PA guidelines, number of breaks taken from PA routine). Adults (N = 626; Mage = 51.47, SD = 16.32) were recruited from the waiting room of a primary care clinic over a 30-day span to complete a questionnaire on PA and goals. The most commonly endorsed PA goals included, weight maintenance, overall health benefits, weight loss, well-being, body tone and/or shape, stress reduction, cardiovascular health, and energy level. Black patients were more likely than White patients to report weight loss and weight maintenance goals. Weight maintenance, overall health, and stress reduction are the goals for which the greatest percentage of individuals reported meeting aerobic PA guidelines. Finally, number of breaks taken and average length of breaks were similar across type of PA goal. A relatively small number of goals reflected a majority of the goals pursued by participants in this study. Racial differences in adoption of weight loss and weight maintenance goals highlight the need for further investigation into such differences. Finally, future research should consider the role that goal setting plays in PA adherence, paying particular attention to disparate levels of PA across racial groups.
Functional genomics of the stable fly,Stomoxys calcitrans, reveals mechanisms underlying reproduction, host interactions, and novel targets for pest control
Authors: Olafson Pia U. , Aksoy Serap , Attardo Geoffrey M. , Buckmeier Greta , Chen Xiaoting , Coates Craig J. , Davis Megan , Dykema Justin , Emrich Scott J. , Friedrich Markus , Holmes Christopher J. , Ioannidis Panagiotis , Jansen Evan N. , Jennings Emily C. , Lawson Daniel , Martinson Ellen O. , Maslen Gareth L. , Meisel Richard P. , Murphy Terence D. , Nayduch Dana , Nelson David R. , Oyen Kennan J. , Raszick Tyler J. , Ribeiro José M. C. , Robertson Hugh M. , Rosendale Andrew J. , Sackton Timothy B. , Swiger Sonja L. , Sze Sing-Hoi , Tarone Aaron M. , Taylor David B. , Warren Wesley C. , Waterhouse Robert M. , Weirauch Matthew T. , Werren John H. , Wilson Richard K. , Zdobnov Evgeny M. , Benoit Joshua B. 
Published: May 2019

AbstractBackgroundThe stable fly,Stomoxys calcitrans, is a major blood-feeding pest of livestock that has near worldwide distribution, causing an annual cost of over $2 billion for control and product loss in the United States alone. Control of these flies has been limited to increased sanitary management practices and insecticide application for suppressing larval stages. Few genetic and molecular resources are available to help in developing novel methods for controlling stable flies.ResultsThis study examines stable fly biology by utilizing a combination of high-quality genome sequencing, microbiome analyses, and RNA-seq analyses targeting multiple developmental stages and tissues. In conjunction, manual curation of over 1600 genes was used to examine gene content related to stable fly reproduction, interactions with their host, host-microbe dynamics, and putative routes for control. Most notable was establishment of reproduction-associated genes and identification of expanded vision, chemosensation, immune repertoire, and metabolic detoxification pathway gene families.ConclusionsThe combined sequencing, assembly, and curation of the male stable fly genome followed by RNA-seq and downstream analyses provide insights necessary to understand the biology of this important pest. These resources and knowledge will provide the groundwork for expanding the tools available to control stable fly infestations. The close relationship ofStomoxysto other blood-feeding (Glossina) and non-blood-feeding flies (medflies,Drosophila, house flies) will allow for understanding the evolution of blood feeding among Cyclorrhapha flies.