bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant Therapies in the Treatment of Aminoglycoside‐Induced Ototoxicity: A Meta‐Analysis
Authors: Gaffney Patrick J. , Shetty Kunal R. , Yuksel Sancak , Kaul Vivian F. 
Published: November 2024

ObjectiveA feared complication of aminoglycoside treatment is ototoxicity, which is theorized to be attributed to the production of aminoglycoside‐induced reactive oxygen species. Previous studies using animal models have suggested that numerous therapies targeting reducing oxidative stress may prevent ototoxicity from aminoglycosides. However, few clinical studies have been conducted on these antioxidants. This systematic review and meta‐analysis examines the effectiveness of antioxidant therapies in the treatment of aminoglycoside‐induced ototoxicity.Data SourcesPubMed, Embase, Web of Science, and ClinicalTrials.gov.Review MethodA literature search was conducted in August 2024. This review sought randomized controlled trials to be conducted on humans to examining otologic outcomes in aminoglycoside‐induced ototoxicity following administration of medications intended to reduce oxidative stress.ResultsA systematic review yielded 2037 results, of which seven studies met inclusion criteria. N‐acetylcysteine (NAC) was investigated in four studies, aspirin in two studies, and vitamin E in one study. Six studies examined the benefit of antioxidant treatments for up to 8 weeks after administration while one study tested subjects' hearing after 1 year. In pooled analysis, two studies assessing NAC showed the greatest reduction in ototoxicity (RR 0.112, 95% CI, 0.032–0.395; p = 0.0007; I2 = 18%), followed by two studies examining aspirin (RR 0.229, 95% CI, 0.080–0.650; p = 0.0057; I2 = 0%). One study performed with vitamin E did not find a reduction in ototoxicity compared to the placebo (RR 0.841, 95% CI, 0.153–4.617; p = 0.8416).ConclusionsMultiple studies have shown that NAC and aspirin are effective in reducing ototoxicity from treatment with aminoglycosides. However, there is a lack of high‐quality evidence. Additional studies should examine whether aspirin and N‐acetylcysteine provide long‐term benefit, and which of the other promising antioxidants translate from animal models.Level of EvidenceN/A Laryngoscope, 2024
Quantifying farmers' Livelihood Efficiency, Regional Indicators and Its Influencing Factors: Implementing an Improved Sustainable Livelihood Framework
Authors: Su Fang , Fan Bingjie , Song Nini , Fahad Shah 
Published: November 2024

ABSTRACTResearch on sustainable livelihoods tend to emphasis on objective and macroregional aspects. However, there is space to expand research on the farmers' livelihoods in the context of poverty alleviation and rural revitalization development. This paper uses a field survey on farmers' livelihood efficiency, influencing factors and mechanisms of farmers' livelihood efficiency in the Qinba mountainous areas of southern Shaanxi China. Based on DEA and Tobit approaches, the authors investigate farmer livelihood efficiency and analyze the disparities according to the farm households' socio‐demographics descriptions. Findings of this study show that, livelihood efficiency is a new entry point of sustainable livelihoods for farmers, and currently, the overall livelihood efficiency of farmers in the study area is low, which needs to be further improved. The results also show that the willingness of environmental protection activities, village busses and government financial expenditure have a significant positive impact on the livelihood efficiency, while the abandonment has a significant negative impact on the livelihood efficiency of farmers. These factors have significant differences in the impact of farmers' technical efficiency and scale efficiency. The results further indicate that, utilization and conversion rate of the existing livelihood capital of farmers is low. Livelihood diversification should be stimulated to enhance “livelihood export” and its operation ability of livelihood capital accumulation. The study findings also propose that, there is a need of reform of dual paths to improve the efficiency of farmers' livelihood, and promote farmers' livelihood development with “wide path” and “wide choice.”
The Great Lakes Winter Grab: Limnological data from a multi‐institutional winter sampling campaign on the Laurentian Great Lakes
Authors: Pu Ge , Shchapov Kirill , Pearce Nolan J. T. , Bowen Kelly , Bramburger Andrew , Camilleri Andrew , Carrick Hunter , Chaffin Justin D. , Cody William , Coleman Maureen L. , Currie Warren J. S. , Depew David C. , Doubek Jonathan P. , Eveleth Rachel , Fitzpatrick Mark , Glyshaw Paul W. , Godwin Casey M. , McKay R. Michael , Munawar Mohiuddin , Niblock Heather , Quintanilla Maci , Rennie Michael , Sand Matthew W. , Schraitle Kimberly J. , Twiss Michael R. , Uzarski Donald G. , Vanderploeg Henry A. , Vick‐Majors Trista J. , Westrick Judy A. , Wheelock Bridget A. , Xenopoulos Marguerite A. , Zastepa Arthur , Ozersky Ted 
Published: November 2024

AbstractInterest in winter limnology is growing rapidly, but progress is hindered by a shortage of standardized multivariate datasets on winter conditions. Addressing the winter data gap will enhance our understanding of winter ecosystem function and of lake response to environmental change. Here, we describe a dataset generated by a multi‐institutional winter sampling campaign across all five Laurentian Great Lakes and some of their connecting waters (the Great Lakes Winter Grab). The objective of Winter Grab was to characterize mid‐winter limnological conditions in the Great Lakes using standard sample collection and analysis methods. Nineteen research groups sampled 49 locations varying widely in depth and trophic status, collecting a range of limnological data. This dataset includes physical, chemical, and biological measurements. These data can be used to examine diverse aspects of Great Lakes ecosystems or integrated with winter observations from other lakes to improve understanding of winter limnology across different aquatic systems.
Atypical Attack of the Dissimilar Metal Welds of a Water–Water Energetic Reactor Nuclear Power Plant Secondary Circuit: Possible Mechanisms of Failure
Authors: Návoj Aleš 
Published: November 2024

ABSTRACTDissimilar metal welds are utilized in the energy industry to connect two materials with different material characteristics. In the case of nuclear power plants, the connected materials tend to be low‐alloyed steel and high‐alloyed material. Despite different material and corrosion properties, under the proper environmental conditions, the used construction materials and weld metals are protected either by a passive layer or by a high‐temperature oxide. Although dissimilar metal welds are used in both primary and secondary circuits, the most frequently documented damage is in the secondary circuit, where, in addition to material heterogeneities, local environmental heterogeneities may form. For dissimilar metal welds in WWER nuclear power plants, a water–water energetic reactor, a subtype of pressure water reactor, we note two main types of attack near the dissimilar fusion boundary: on the carbon steel side or on the high‐alloyed weld metal side (X10CrNiMoN16‐25‐6). The possible causes of the latter “atypical” corrosion attack are debated and can be generalized as a consequence of change of the grain boundary condition.
Study on the Effect of Dry and Wet Cycle Time Ratio on the Corrosion Behavior of 2198 Aluminum–Lithium Alloy
Authors: Liu Yingyan , Deng Zhibin , Zhang Qian , Hu Xiao , Yue Hang , Tang Haiping , Li Guotao 
Published: November 2024

ABSTRACTThe corrosion of 2198 aluminum–lithium alloy in a marine atmospheric environment was simulated using a wet–dry alternating experimental setup. Weight‐loss measurement methods, electrochemical impedance spectroscopy (EIS), scanning electron microscopy/energy‐dispersive spectroscopy (SEM/EDS), macroscopic morphology testing, three‐dimensional morphology testing, and X‐ray photoelectron spectroscopy (XPS) were used to study the wet–dry alternating corrosion behaviors and mechanisms of 2198 aluminum–lithium alloys under simulated marine atmospheric environment. The results indicate that corrosion weight loss increases with decreasing wet‐to‐dry ratios, accompanied by an increase in the corrosion rate. Various data suggest that the primary corrosion products are composed of Al2O3, AlO(OH), and AlCl3. The reduction in the wet‐to‐dry ratio leads to the enrichment of Cl⁻ within the corrosion products, extending the contact time between the substrate and the medium, thereby intensifying the hydrolysis of Al³⁺. This exacerbates the dissolution at pitting sites, which in turn erodes and breaks down the corrosion product film, accelerating the overall corrosion process.
LINC01764 promotes colorectal cancer cells proliferation, metastasis, and 5‐fluorouracil resistance by regulating glucose and glutamine metabolism via promoting c‐MYC translation
Authors: Duan Ran , Zhai Yujia , Wang Qiushuang , Zhao Liqin , Wang Yixuan , Yu Nuoya , Zhang Jieyun , Guo Weijian 
Published: November 2024

AbstractFew biomarkers are available for predicting chemotherapeutic response and prognosis in colorectal cancer (CRC). Long‐noncoding RNAs (lncRNAs) are essential for CRC development and growth. Therefore, studying lncRNAs may reveal potential predictors of chemotherapy response and prognosis in CRC. LINC01764 was analyzed using datasets from Fudan University Shanghai Cancer Center's advanced CRC patients’ RNA‐seq and The Cancer Genome Atlas datasets. Gene set enrichment analysis was employed to detect related pathways. Cotransfection experiments, RNA pulldown assays, RNA‐binding protein immunoprecipitation, protein synthesis activity, and dual‐luciferase reporter assays were performed to determine interactions among LINC01764, hnRNPK, and c‐MYC. High LINC01764 expression correlates with metastasis, a poor response to FOLFOX/XELOX chemotherapy, and a poor prognosis in CRC. LINC01764 enhance glycolysis and glutamine metabolism to promote CRC cells proliferation, metastasis, and 5‐fluorouracil (5‐FU) resistance. LINC01764 specifically binds to hnRNPK, facilitating its interaction with c‐MYC mRNA and promoting internal ribosome entry site (IRES)‐dependent translation of c‐MYC, thereby exerting oncogenic effects. LINC01764 induced 5‐FU chemoresistance by upregulating the c‐MYC, glucose, and glutamine metabolism pathways, which downregulated UPP1, crucial for activating 5‐FU. Conclusively, LINC01764 promotes CRC progression and 5‐FU resistance through hnRNPK‐mediated‐c‐MYC IRES‐dependent translational regulation, which suggests its potential as a predictor of CRC chemotherapy response and prognosis.
Repeatability of diffusion kurtosis tensor parameters in muscles of the lower legs
Authors: Mathew Ethan , Dortch Richard , Damon Bruce , Ragunathan Sudarshan , Quarles C. Chad 
Published: November 2024

AbstractPurposeThe aim of this study was to provide measurements from and investigate the repeatability of diffusion kurtosis tensor parameters in the muscles of the lower legs.MethodsTest–retest acquisition of a kurtosis tensor sequence was performed in 13 healthy volunteers. Quantitative kurtosis tensor parameters were derived, and repeatability of each parameter was evaluated by muscle group and over the whole muscle through intraclass correlation coefficient (ICC) and within‐subject coefficient of variation (wsCV). Bland–Altman analysis was also conducted. Differences in parameter values by muscle group were investigated through an analysis of variance.ResultsAxial kurtosis and radial kurtosis values from the test data were 0.63 ± 0.04 and 0.70 ± 0.05, respectively. Kurtosis tensor parameters from all muscle groups and over the whole muscle had wsCV below 15%. ICC for the parameters from most muscle groups was above 85%, with the lowest ICC over the whole muscle being 88.39%. The medial gastrocnemius and extensor digitorum longus showed highest repeatability. Mean, axial, and radial diffusivity had higher wsCV despite being lower‐order terms than kurtosis.ConclusionThis study sought to examine the repeatability of diffusion kurtosis tensor–derived parameters in the legs and verify that they could potentially be used as longitudinal imaging metrics. wsCV values from test–retest data indicated high repeatability throughout all examined muscle groups. There were minimal differences in kurtosis and diffusivity parameters between muscle groups in this healthy volunteer cohort.
Reproducibility of liver ADC measurements using first moment optimized diffusion imaging
Authors: Allen Timothy J. , van der Heijden Rianne A. , Simchick Gregory , Hernando Diego 
Published: November 2024

AbstractPurposeCardiac‐induced liver motion can bias liver ADC measurements and compromise reproducibility. The purpose of this work was to enable motion‐robust DWI on multiple MR scanners and assess reproducibility of the resulting liver ADC measurements.MethodsFirst moment‐optimized diffusion imaging (MODI) was implemented on three MR scanners with various gradient performances and field strengths. MODI‐DWI and conventional Stejskal‐Tanner monopolar (MONO) DWI were acquired in eight (N = 8) healthy volunteers on each scanner, and DWI repetitions were combined using three different averaging methods. For each combination of scanner, acquisition, and averaging method, ADC measurements from each liver segment were collected. Systematic differences in ADC values between scanners and methods were assessed with linear mixed effects modeling, and reproducibility was quantified via reproducibility coefficients.ResultsMODI reduced left–right liver lobe ADC bias from 0.43 × 10−3 mm2/s (MONO) to 0.19 × 10−3 mm2/s (MODI) when simple (unweighted) repetition averaging was used. The bias was reduced from 0.23 × 10−3 mm2/s to 0.06 × 10−3 mm2/s using weighted averaging, and 0.14 × 10−3 mm2/s to 0.01 × 10−3 mm2/s using squared weighted averaging. There was no significant difference in ADC measurements between field strengths or scanner gradient performance. MODI improved reproducibility coefficients compared to MONO: 0.84 × 10−3 mm2/s vs. 0.63 × 10−3 mm2/s (MODI vs. MONO) for simple averaging, 0.66 × 10−3 mm2/s vs. 0.50 × 10−3 mm2/s for weighted averaging, and 0.61 × 10−3 mm2/s vs. 0.47 × 10−3 mm2/s for squared weighted averaging.ConclusionThe feasibility of motion‐robust liver DWI using MODI was demonstrated on multiple MR scanners. MODI improved interlobar agreement and reproducibility of ADC measurements in a healthy cohort.
The epidermal growth factor receptor inhibitor gefitinib enhances in vitro and in vivo sensory axon regeneration and functional recovery following transection in a mouse median nerve injury model
Authors: Topley Maxwell , Sparks Payton , Crotty Anne‐Marie , Kawaja Michael , Hendry J. Michael 
Published: November 2024

AbstractIntroductionThe epidermal growth factor receptor (EGFR; ErbB1), a membrane bound receptor tyrosine kinase, is hypothesized to have an inhibitory influence on peripheral nerve regeneration. This study examines the impact of EGFR inhibition on nerve regeneration using the commercially available small molecule inhibitor gefitinib.MethodIn vitro assays included neurite outgrowth of cultured dorsal root ganglion (DRG) neurons from adult C57Bl/6 wildtype mice on immobilized chondroitin sulfate proteoglycans (CSPG). Following forelimb median nerve injury, EGFR expression, number of regenerated neurons (using retrograde labeling) and myelination of motor and sensory neurons were compared between mice that received either gefitinib or vehicle. Functional recovery was assessed using grip strength.ResultsEGFR expression on DRG and spinal motor neurons was confirmed. Gefitinib significantly increased neurite outgrowth in medium sized (30–50 μm) DRG neurons, resulting in longer neurites (183 ± 36 μm) compared with CSPG alone (49 ± 9 μm). After median nerve injury, significantly greater numbers of sensory neurons (638 ± 112 vs. 301 ± 81), but not motor neurons (31 ± 12 vs. 42 ± 13) regenerated in animals treated with gefitinib compared with controls. Regenerated axons in gefitinib treated animals displayed significantly greater diameter and increased g‐ratio compared with controls. Grip strength recovered more quickly in animals receiving gefitinib compared with controls (27.6 vs. 19.1 g 18 days post‐injury).DiscussionThis study provides data supporting the role of EGFR as a negative regulator of sensory but not motor neuron regeneration. Further, it demonstrates versatile potential uses of existing pharmaceuticals.
Sketched and Truncated Polynomial Krylov Methods: Evaluation of Matrix Functions
Authors: Palitta Davide , Schweitzer Marcel , Simoncini Valeria 
Published: November 2024

ABSTRACTAmong randomized numerical linear algebra strategies, so‐called sketching procedures are emerging as effective reduction means to accelerate the computation of Krylov subspace methods for, for example, the solution of linear systems, eigenvalue computations, and the approximation of matrix functions. While there is plenty of experimental evidence showing that sketched Krylov solvers may dramatically improve performance over standard Krylov methods, especially when combined with a truncated orthogonalization step, many features of these schemes are still unexplored. We derive a new sketched Arnoldi‐type relation that allows us to obtain several different new theoretical results. These lead to an improvement of our understanding of sketched Krylov methods, in particular by explaining why the frequently occurring sketched Ritz values far outside the spectral region of do not negatively influence the convergence of sketched Krylov methods for . Our findings also help to identify, among several possible equivalent formulations, the most suitable sketched approximations according to their numerical stability properties. These results are also employed to analyze the error of sketched Krylov methods in the approximation of the action of matrix functions, significantly contributing to the theory available in the current literature.
Clinical Control and Quality of Life in Patients With Chronic Rhinosinusitis With Asthma: A Study on the Effects of Endoscopic Sinus Surgery
Authors: Ma Rongfeng 
Published: November 2024

AbstractObjectiveTo determine the impact of endoscopic sinus surgery (ESS) on chronic rhinosinusitis with asthma (CRSwA) patients' clinical control and quality of life.Study DesignA randomized controlled trial involving 150 CRSwA patients, equally divided into surgical and control groups.SettingParticipants were matched for age, gender, illness duration, and computed tomography (CT) grading of the sinuses.MethodsRandom allocation was conducted using a computer‐generated table.ResultsThe surgical group exhibited significant symptom score improvements across all metrics (P < .001). Lung function parameters showed substantial gains, with forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratios significantly higher than the control group (P < .001). Quality of life scores, measured by RQLQ and AQLQ, improved significantly in the surgical group (P < .001). At 6 months, correlations between lung function and CT grading of the sinuses were evident, with negative and positive correlations, respectively (P < .05). Inflammatory markers and medication usage were notably reduced (P < .001, P < .05), with low adverse event rates (1%).ConclusionESS is effective in enhancing clinical outcomes and quality of life for CRSwA patients, reducing inflammation and medication needs, thus supporting its use as a beneficial treatment.
Corporate Social Responsibility Programs and Employee Retention: The Mediating Effects of Employee Trust in Organization
Authors: Ta'amneh Mohammad Mahmoud , Ta'amneh Abdallah Mohammad , Eid Ali Ibrahim Abu 
Published: November 2024

ABSTRACTThis study aims to examine the impact of corporate social responsibility initiatives on employee retention rates in private hospitals in Jordan. Additionally, this study investigates the mediator function of employee trust in private hospitals regarding the relationship between CSR initiatives and employee retention. A stratified sample of 363 personnel from private hospitals in northern Jordan is used, representing four distinct groups: physicians, nurses, technicians, and administrators. The data analysis uses the structural equation modeling (SEM) technique. The results indicate that corporate social responsibility (CSR) measures and trust in private hospitals in Jordan benefit employee retention. Furthermore, the level of trust in hospitals plays a crucial role in mediating the connection between corporate social responsibility (CSR) initiatives and the ability to retain employees. These findings hold promise for the healthcare sector in Jordan, offering potential solutions to the pressing issue of employee retention and the potential to improve patient care quality significantly.
Shape design optimization of a flat endmill tool
Authors: Kalu‐Uka Abraham , Moerman Kevin , Eberhard Peter 
Published: November 2024

AbstractAmong the many possible metal‐cutting processes, milling is regarded as one of the most widely applied processes to machine different engineering materials productively. During the milling process, there is relative motion between the endmill tool and the workpiece. Energy is required to drive the cutting force used by the tool in separating the chips from the workpiece. Several studies have focused on the effects of milling process parameters on the cutting force, for instance by varying the cutting parameters, machining properties and the extent of cooling/lubrication. Other studies have explored the influence of tool geometry and material properties on the cutting force. Results from these studies have brought about improvements in the design of milling machinery and tools. The current study presents a novel automated approach for tool geometry optimization which is fully coded in Matlab. An automated and parametrized endmill design procedure was created featuring input parameters such as rake angle, relief angle, clearance angle and helix angle, all of which have been shown, through numerous studies, to influence cutting forces. The parameters were here used to generate the shape profile for one cutting edge of a flat endmill. This cutting edge profile is next copied and rotated, as per the design's pitch angle, to form the complete set of cutting flutes for the flat endmill. Next, the surface defined by the completed profile is meshed using quadrilateral elements. The 3D endmill design is then formed by extruding, and twisting as per the helix angle, this quadrilateral mesh to form a solid hexahedral mesh. Finally, an automated iterative optimization process was defined, featuring the above parametrized design process coupled with Abaqus‐based finite element simulation of the milling process. The expected result is that the proposed optimization procedure will be able to identify the endmill design parameters which minimize the cutting force. At the completion of the optimization, a minimized maximum resultant cutting force value is obtained from using the newly optimized endmill. The resultant cutting force was reduced by 17.6%. It is anticipated that the automated design, meshing and simulation‐driven optimization approach is generalizable to other tool design variations.