bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of postoperative complications in bladder cancer patients
Authors: Shi Tianli , Yu Dongdong , Xu Yang , Huang Xiaohui 
Published: November 2024

Abstract

Background
Bladder cancer, a significant health concern worldwide, often necessitates diverse surgical interventions and postoperative treatments. Understanding the complications arising from these procedures is vital for enhancing patient outcomes and quality of life.

Methods
This study encompassed 80 bladder cancer patients, evaluating their demographic characteristics, systemic conditions, cancer stages, tumor diameter, surgical procedures, and postoperative treatments. The occurrences and types of complications were meticulously documented, alongside the duration and clinical outcomes of these complications. Different surgical procedures were analyzed to discern their respective complication rates.

Results
In all 80 patients, infections (43.75%) emerged as the most common, followed by bladder spasms (16.25%). Notably, complications varied among different surgical procedures, with infection, bladder spasms, and bleeding being prominent in various cases. The correlation analysis did not demonstrate correlation (r = 0.13, p = 0.26) between bladder cancer stage and duration of complication. Post-treatment interventions, especially anti-infection therapies, showcased positive results, with the majority of patients maintaining or improving their condition after specific treatments.

Conclusion
Our study underscores the diverse landscape of postoperative complications in bladder cancer patients. The findings emphasize the importance of tailored interventions based on specific complications, cancer stages, and surgical procedures.
In situ growth of carbon nanotubes on fly ash substrates
Authors: Liu Song , Wang Tianhao , Wang Hongchang , Hui David , Li Haitao , Gong Minghui , Cai Bianyue , Zhang Duanyang , Xu Kechun , Tang Aoyu 
Published: November 2024

Abstract
Carbon nanotubes (CNTs) are one-dimensional nanomaterials exhibiting specialized structures and exceptional mechanical, electrical, and chemical properties. CNTs find application in the fabrication of composite materials, material modification, and hydrogen storage. However, their widespread adoption in material modification is challenging due to their expensive manufacturing and proclivity toward agglomeration. This review expounds the evolution and future directions of in situ growth of CNTs on fly ash substrates through chemical vapor deposition or microwave heating methods. The unique structure and composition of fly ash engenders low-carbon and environmentally friendly properties while facilitating the self-growth of CNTs on its substrate. This paper delves into the characteristics and growth mechanism of the in situ-grown CNTs, with an analysis of mechanical properties, wave absorption, friction, applications, and innovations of fly ash in situ-grown CNTs as modifiers, adsorbents, and additives. The prepared fly ash in situ-grown CNTs have various advantages such as better dispersion properties, lower carbon emissions, and reduced preparation cost, enhancing their applicability in material modification and creation.
Bioinspired neuromelanin-like Pt(iv) polymeric nanoparticles for cancer treatment
Authors: Gómez-Herrera Roger , Alfonso-Triguero Paula , Mao Xiaoman , Mancebo-Aracil Juan , Montpeyó David , Novio Fernando , Lorenzo Julia , Ruiz-Molina Daniel 
Published: November 2024

Abstract
To expand the chemotherapeutic potential of platinum complexes, different approaches have been followed, two of the most relevant being their administration as the prodrug Pt(iv) and encapsulation in nanocarriers. Herein, we demonstrate how neuromelanin may become a good bioinspiration for the synthesis of nanoparticles (NPs), combining both approaches. For this, complex PtBC reacts with sodium periodate, inducing a melanization process and the formation of nanoparticles. In vitro results on non-malignant human fibroblast cells (1Br3G), human cervical cancer, murine glioma (GL261), and human ovarian cancer confirmed its therapeutic efficacy. The role of the Pt(iv) ion on the cytotoxicity effects was confirmed by comparison with the results obtained for a family of nanoparticles obtained with nordihydroguaiaretic acid under the same experimental conditions. Finally, intranasal administration of the NPs in orthotopic glioblastoma multiforme murine models in female C57BL/6 mice showed excellent in vivo biodistribution and tolerability. Overall, this innovative approach represents a step toward more specific and less toxic therapies in the field of cancer chemotherapy.
Motivations for farmers’ participation in agri-environmental scheme in the EU, literature review
Authors: Podruzsik Szilárd , Fertő Imre 
Published: November 2024

Abstract
Agri-environmental schemes (AESs) play a pivotal role in aligning agricultural practices with environmental objectives, promoting sustainable land management, and conserving biodiversity. This article presents a comprehensive synthesis of recent advancements in AES research within the European Union context, focusing on ecological, economic, and socio-political dimensions. Through a systematic review of literature published since 2013, we identify emerging trends, gaps, and research priorities, providing novel insights into AES effectiveness. We examine the factors that influence participation in AES such as biodiversity, habitat fragmentation, and agricultural ecosystem services. We also explore the economic factors influencing farmer participation, including financial incentives, income stability, and cost–benefit analysis. Furthermore, we investigate the socio-political dimensions of AES, including institutional frameworks, stakeholder engagement, and the role of trust in programme implementation. Key findings highlight the need for adaptive management strategies, incentive structures aligned with environmental objectives, and inclusive governance mechanisms to enhance AES effectiveness. Our research underscores the importance of context-specific approaches that account for farm characteristics, socio-economic factors, and institutional arrangements. Practical implications for policymakers, practitioners, and stakeholders are discussed, emphasizing the importance of evidence-based policymaking and iterative learning in promoting sustainable agriculture and environmental conservation.
DECADÊNCIA, VALOR E ESGOTAMENTO EM NIETZSCHE: DA DINÂMICA DA VONTADE DE PODER À TRANSVALORAÇÃO DE TODOS OS VALORES
Authors: Silveira Rafael Gonçalves , Da Silveira Rafael Gonçalves 
Published: November 2024

Resumo: Neste artigo pretendemos abordar a relação entre os conceitos de decadência (décadence), valor (verth), esgotamento (Erschöpfung) e vontade de poder (Wille zur Macht) na obra de Friedrich Nietzsche. O principal objetivo é demonstrar que estes conceitos se relacionam a partir de 1888, em vistas ao projeto nietzschiano de transvaloração de todos os valores (Umwerthung aller werthe) em O Anticristo. Por fim, ressalto que não é possível compreender a transvaloração sem uma análise da ligação entre estes conceitos.
VIRTUDE, TELEOLOGIA E DEONTOLOGIA: O UTILITARISMO DE MILL, SUAS CRÍTICAS E SUAS DEFESAS
Authors: De Souza Grégori 
Published: November 2024

Temos por ideia geral de que o que se segue de uma boa intenção é uma boa ação e, por conseguinte, um bom resultado. Para identificar o locusprimário do valor moral utilizamos as teorias éticas, sejam elas pautadas na intenção, na ação produzida ou no resultado da ação. O escopo geral desse trabalho é identificar e analisar um dos principais pontos de vista éticos da filosofia moral, a saber, o utilitarismo. Para tanto, partiremos de uma diferenciação básica entre ética da virtude, ética deontológica e ética teleológica. Apresentaremos os fundamentos do utilitarismo, sobretudo aquele citado por John Stuart Mill, os argumentos de crítica e os argumentos de defesa deste como teoria ética capaz de identificar aquele locus primário.
РАБОЧИЕ ЗАПИСИ А.А. ЖДАНОВА: ИСТОЧНИКОВЕДЧЕСКИЙ АНАЛИЗ
Authors: Т.Ю. ТОЛСТИКОВ 
Published: November 2024

В статье анализируются черновые записи секретаря ЦК ВКП(б), первого секретаря Ленинградского горкома и обкома ВКП(б) А.А. Жданова. В настоящее время историки все чаще обращаются к рабочим записям руководителей СССР, но заметки А.А. Жданова по-прежнему остаются практически не введенными в научный оборот. В источниках этого типа могут содержаться ценные сведения по различным вопросам советской истории, однако при исследовании записей необходимо учитывать их характерные особенности. В данной работе воссоздается история формирования личного фонда А.А. Жданова, выделяются основные виды записей, рассматриваются особенности этого источника. В заключении определены проблемы, возникающие при изучении заметок партийного руководителя, и намечены перспективы их дальнейшего исследования.
Modern researchers of the political history of the USSR are actively studying the working notes of Soviet leaders. These documents provide a unique insight into various aspects of Soviet history and can be a valuable source of information. In this article, the notebooks of the Secretary of the Central Committee of the CPSU(b), the first secretary of the Leningrad Regional Committee Andrei Zhdanov, are considered from a source study perspective. The records contain important information about the history of party building in the 1930s and 1940s, the development of ideology, the situation in Leningrad, and the relationship between the USSR and Finland. The working notes of the party leader are known in historical literature. During the period from 1990 to 2010, several works were published that quoted Zhdanov’s notes, but those references were fragmentary. The features of the source, types of records, characteristics of handwriting and writing materials have not been studied. The author examines the history of the receipt of these documents in the Russian State Archive of Socio-Political History (RGASPI) and identifies their distinctive features. In the article, the entries are divided into categories according to various types, including lists of current tasks, summaries of reports, draft resolutions, decisions, letters, quotations, and brief descriptions of speeches by various figures. The author shows the development of records from 1924 to 1948, describing changes in handwriting, writing materials and the contents of documents. In conclusion, the main problems encountered during the analysis of these records are presented, and the potential for future research on this source is identified.
Feasibility of Using Harvested Rainwater and Stormwater in Concrete Mixtures
Authors: Raju Vidya B. , Puttaswamaiah Shivashankara G. 
Published: November 2024

Freshwater preservation and conservation are becoming more and more imperative as worldwide populations increase. Nowadays, making concrete needs huge quantities of freshwater. The present research shows research findings on the feasibility of substituting freshwater in concrete mixing with surface runoff water, RCC rooftop harvested rainwater and conventional water. RCC rooftop harvested water(HRW), surface runoff water(SW), bore well (BW) water, and potable water (PW) were the four sources from which samples were collected. Physical and chemical analysis was carried out on four various sources as per standard methods [APHA]. The performance of four different sources of water on physical properties i.e., setting time, workability, and mechanical properties of ordinary Portable cement (OPC) were examined and compared with conventional concrete specimens. According to the findings, all of the water's qualities from the various sources satisfy the recommended IS 456 (2012) and other standards for concrete-quality water. No significant change was observed in the mechanical properties of four different sources of water samples that were superior to those of conventional concrete. utilizing HRW and SW as alternatives to freshwater could save a lot of freshwater while also protecting the environment.
Keywords: Freshwater, stormwater, harvested rainwater, Setting time, Compressive strength.
Treatment of Elbow Ulnar Collateral Ligament Injury in a 9-Year-Old Acrobatic Dancer Using Platelet-Rich Plasma
Authors: Haile Henok , Whitney Kristin , Bauer Andrea 
Published: November 2024

Case:
We present the case of a 9-year-old female acrobatic dancer who sustained left elbow dislocation during a routine. Advanced imaging revealed proximal ulnar collateral ligament (UCL) tear. A significant limitation in elbow range of motion (ROM) after initial treatment with an elbow brace and physical therapy prompted a dynamic bedside ultrasound (US) test, which demonstrated persistent instability of the UCL. US-guided injection of platelet-rich plasma (PRP) to the UCL was performed. After PRP treatment, the patient regained complete elbow ROM and a full return to her activity.

Conclusion:
Platelet-rich plasma can be used as a nonoperative treatment of pediatric elbow UCL injuries.
Double Popliteus Sign in Multiligament Knee Injury
Authors: Whicker Emily , Afetse Eddie K. , Abouhaif Taylor M. , Knezic Noah , Hackett Thomas R. 
Published: November 2024

Case:
We report 2 rare cases of lateral bucket-handle meniscus tears that had displaced into the popliteal space within the context of multiligament knee injuries. In combination with a lateral meniscal root repair, an arthroscopic inside-out repair and an all-inside repair were successfully performed.

Conclusion:
When a double popliteus sign appears on magnetic resonance imaging, the surgeon should anticipate using advanced and unconventional techniques to reduce the meniscus into the joint. In addition, readiness for a meniscal root repair is crucial.
WITHDRAWN: Characterized raw Leucaena leucocephala pod (LLP) as biosorbent produced high adsorption of Pb(II) ions in a synthetic aqueous solution
Authors: Razak Noor Harliza Abd , Idris Juferi , Musa Mohibah , Jaapar Jepri , Puasa Siti Wahidah , Mukhelas Nazmi 
Published: November 2024

Abstract

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
The role of GABA in semantic memory and its neuroplasticity
Authors: Jung JeYoung , Williams Stephen , Ralph Matthew Lambon 
Published: November 2024

Abstract

A fundamental aspect of neuroscience is understanding neural functioning and plasticity of the brain. The anterior temporal lobe (ATL) is a hub for semantic memory, which generates coherent semantic representations about the world. GABAergic inhibition plays a crucial role in shaping human cognition and plasticity, but it is unclear how this inhibition relates to human semantic memory and its plasticity. Here, we employed a combination of continuous theta burst stimulation (cTBS), MR spectroscopy and fMRI to investigate the role of GABA in semantic memory and its neuroplasticity. Our results demonstrated that the inhibitory cTBS increased regional GABA levels in the ATL and decreased ATL blood-oxygen level-dependent (BOLD) activity during semantic processing. Importantly, changes in GABA levels were strongly associated with changes in regional activity induced by cTBS. These results suggest that GABAergic activity may be the mechanism by which cTBS induces after effects on cortical excitability. Furthermore, individuals with better semantic performance exhibited selective activity in the ATL, attributable to higher concentrations of inhibitory GABA, which can sharpen distributed semantic representations, leading to more precise semantic processing. Our results revealed a non-linear, inverted-U-shape relationship between GABA levels in the ATL and semantic performance, thus offering an explanation for the individual differences in the cTBS effect on task performance. These results provide neurochemical and anatomical specificity in shaping task-related cortical activity and behaviour. Understanding the link between neurochemistry and semantic memory has important implications for understanding individual differences in semantic behaviour and developing therapeutic interventions for patients with semantic impairments.
Design of a metaheuristic artificial intelligence (AI) model for an optimal photovoltaic module cooling system
Authors: Kenfack Armel Zambou , kemle Symphorien Tchimoe , Nematchoua Modeste Kameni , Chara-Dackou Venant Sorel , Simo Elie , Temene Hermann Djeudjo 
Published: November 2024

Abstract

The absorption and heat management processes of the PV module are very diverse and in constant development. The advantages and disadvantages of each process imply an effective method of optimal choice. This paper therefore aims to design a multi-objective particle swarm optimization (MOPSO) model to search for a better configuration of cooled PV/T. Seven objective functions were implemented. The Cost of Energy (COE), Net Present Value (NPV), Internal Rate of Return (IRR, Ergonomic Factor (EF) and Payback Time (CPBT) revealed that photovoltaic /thermal systems (PV/T) with hybrid cooling (Passive/Active) with forced convection PCM/Air (phase change materials) are better. Likewise, the evaluation of the total annual cost (TAC) shows that air cooling systems are more economical. On the other hand, the evaluation of the \(\:{\text{C}\text{O}}_{2}\) cost shows that hybrid cooling systems with NanoPCM /TNF (Ternary Nanofluids) are less polluting. However, the return on investment time of the cooled PV module unit is less than 4 years and the sensitivity of savings of more than $20 in just 5 years of life. The MOPSO method deduced that PV/T systems with hybrid PCM/Air cooling are optimal compared to hybrid TEG/NF (thermoelectric / Nanofluid) systems which are the least efficient. The developed algorithm is very precise for choosing an optimal solar system.
Therapeutic effects of Lycopene loaded Exosomes alleviates on Deoxynivalenol induced testicular injury in mice via the Cyt-c/Caspase-3/Bax/Bcl-2 signaling pathway modulation
Authors: Ru Feng , Velmurugan Ramaiyan , Li Chunfeng , Mu Ying , Tian Haiyan , Zhou Lina , Cao Xiaoming 
Published: November 2024

Abstract

Background
Deoxynivalenol (Dex), a nonsteroidal estrogenic mycotoxin found in grains, has estrogen-like effects on the reproductive system. Lycopene (Lyc), a carotenoid found in tomatoes, have significant antioxidant and anti-inflammatory potential. Unfortunately, Dex-induced testicular spermatogenic dysfunction therapies are scarce and the underlying molecular pathways are unclear. The purpose of this study was to examine the mechanism and protective impact of Lycopene-loaded adipose stem cells derived exosomes (Lyc-Exo) against mice testicular damage caused by Dex.
Methods
ADSC-Exo were separated via ultracentrifugation in which followed by Lyc was loaded into exosomes through electroporation method and characterized via TEM, NTA and western blotting. In vivo studies, the effect of Lyc-Exo on Dex induced testicular injury in mice model was examined with various biochemical indexes such as testicular sperm motility, antioxidant status, pro-inflammatory cytokines and apoptosis, histopathology were studied. In addition, the in vitro GC-1 spg cell line were assessed by MTT, CCK-8-cell counting, cytometry, Cell migration and DCF-ROS assay. Lastly, the influence of Lyc-Exo on Dex-induced alterations in signaling transcription factor and apoptotic marker gene expression were assessed by RT-PCR analysis
Results
Lyc-Exo-Dex induced changes in testicular and epidydimal weights, and normalized serum testosterone levels. Moreover, Lyc-Exo enhanced testicular oxidative stress (TBARS, NO, GSH, CAT activity), inflammatory mediators (IL-1β, TNF-α, NF-κβ p65 gene expression), and reduced proapoptotic proteins by activating the Cyt-c/Caspase-3/Bax/Bcl-2 signaling pathway. In vitro tests revealed that Lyc-Exo-Dex therapy decreased the cell proliferation which augmented anticancer efficiency, gene expression, and apoptotic effect in GC-1 spg cells.
Conclusion
Our findings indicate that Lyc-Exo protects against Dex-induced testicular damage and oxidative stress, suggesting a possible therapy for spermatogenic dysfunction.
Anti-fibrillation Effect of Gold Nanoparticles Conjugated with Boswellic Acid on α-synuclein
Authors: Gharb Masoumeh , Mozafari Farima , Arghavani Payam , Saboury Ali Akbar , Riazi Gholamhossein 
Published: November 2024

Abstract

Neurodegenerative diseases such as Alzheimer’s and Parkinson’s are characterized by the death of neurons in specific brains. α-synuclein (α-Syn) is a key factor in Parkinson’s disease (PD), forming toxic fibrils when misfolded. Natural products, such as Boswellia serrata, have shown promise in treating neurodegenerative diseases. However, the poor pharmacological performance of Boswellia acids (BAs) limits their effectiveness. Enhancing the bioavailability of BAs through nanocarriers could be a solution. This study explores the potential of β-Boswellic acid conjugated to gold nanoparticles (GNPs) as a novel PD treatment. Covalent and noncovalent conjugations of β-Boswellic acid to GNPs (GNP-BA) were developed to study their impact on α-Syn fibrillation in vitro. The successful synthesis of spherical GNPs (< 32 nm) was confirmed using high-resolution transmission electron microscopy (HR-TEM) and field emission scanning electron microscopy (FESEM). UV-visible and Fourier-transform infrared (FTIR) spectroscopies confirmed the conjugation of BA to GNPs. Specific interactions between α-Syn and GNP-BA conjugates were observed, with GNPs noncovalently bound to BA effectively inhibiting fibril formation. Thioflavin T (ThT) assay and atomic force microscopy (AFM) further supported the inhibitory effect of designed GNPs on α-Syn fibrillation, suggesting a potential therapeutic approach for PD treatment.
Space-Safeguarding vs Space-Management: Agent Based Modelling to Assess the Role and Effectiveness of Non-Pharmaceutical Interventions in COVID-19 Mitigation
Authors: He Vivian , Simeoni Shelly , Yiannakoulias Niko 
Published: November 2024

Abstract

Background:
During the COVID-19 pandemic, school closures may have deprived students of crucial opportunities for growth and development. This study is motivated by the challenge of responding to future infectious disease pandemics while minimising the educational and social impacts school closures may have. Specifically, we investigated the efficacy of capacity limits and mandated masking protocols as non-pharmaceutical interventions (NPIs) in mitigating the transmission of COVID-19 in a post-secondary setting.
Methods
We developed an agent-based model (ABM) parameterized with demographic and COVID-19 epidemiological characteristics to simulate the spread of disease within a university community. Model parameters account for the spatiotemporal distribution and movement patterns of the agent population, the exogenous rate of infection, and the nature of agent interactions at specific locations.
Results
Overall infection rates were reduced when on-campus masking (between − 275% and − 330%) or on-campus capacity limits (between − 40% and − 43%) were implemented. Off-campus capacity limits were ineffective as a sole intervention. The combination of masking and on-campus capacity limits resulted in infection levels higher than when only masking was implemented but lower than when only capacity limits were implemented and in the absence of all restrictions. Among the interventions studied, masking alone was the most effective in reducing the spread of COVID-19.
Conclusions
The individual implementation of both campus capacity limits and mandated masking influenced the nature of COVID-19 transmission within the university setting, with the latter proving to be much more effective as a sole non-pharmaceutical intervention than the former. Their combined use led to worse outcomes in all modelled scenarios, highlighting the potential benefits of ensuring that lower risk environments remain open. Further research is needed to identify the optimal combination of interventions to strike a balance between alleviating pressure on the healthcare system and ensuring societal well-being.