bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Iddah Period as a Reason for Cancellation of Marriage
Authors: Romadoni Rahayu Mulia 
Published: September 2019

The iddah period is a waiting period that applies to a woman whose marriage is broken legally through a divorce or physically through the death of a husband. Any woman who has not had a prior marriage must observe the iddah period. As one of the legal conditions of marriage, failure to complete the iddah period can result in the cancellation of any secondary marriages. In this study, judges release a verdict in accordance with the laws and legislation of Indonesia, namely Law No. 1 of 1974 on Marriage and a compilation of Islamic law found in Al-Qur'an and Hadith. This article uses legal research based on positive laws including judicial decision. This study concluded that if a marriage is prohibited for a failure to satisfy the condition of iddah, that marriage must be canceled. This article employs statute and conceptual approaches to legal research, as well as case study methodology, with the aim of departing from the views and doctrines that develop in law in order to build a legal argument that addresses legal issues. Analyzing the Decision of the Mojokerto Religious Court Number 1365/Pdt.G/2014/PA.Mr, this study argues that prospective spouses are responsible for awareness of their prospective partners’ marriage eligibility and fulfillment of all requirements, material and formal, clearly stipulated in state and religious law.
Keywords: Iddah, Islamic Law, Marriage Cancellation
The Application of the MFN Principle into 'the Over Top Companies' in Investment Activities of Indonesia
Authors: Ansory Wachid Aditya , Widiyanti Ikarini Dani , Kumala Sari Nuzulia 
Published: September 2019

The Most-Favored-Nation (MFN) principle is one of international consensuses, especially for countries registered as members of the World Trade Organization (WTO). The principle is related to investment and international trade within the framework of economic liberalization. At its core, the MFN principle ensures equitable treatment of all parties economically active within a country. Recently, in Indonesia, the Over Top company conducted business activities without paying taxes to the government. The case of the Over Top company highlights an unfair business situation in Indonesia, enabled by the Indonesian government through a poorly established monitoring system and codification of laws. This study argues that the absence of taxation, regulation, and fraud laws for the Over Top Companies in Indonesia, and the Indonesian government is responsible for the enforcement and maintenance of tax laws and the MFN principle for all entities conducting business in the state.
Keywords: MFN Principle, Over Top Companies, Investment in Indonesia.
Law Enforcement of Criminal Defamation Through Electronic Media
Authors: Putri Septavela Gusti , Irianto Echwan , Prihatin AN Dodik 
Published: September 2019

Defamation through Electronic Media as regulated in Article 27 paragraph (3) of Law No. 19 of 2016 on amendments to Law No. 11 of 2008 on Information and Electronic Transactions does not explain in detail the elements of "insulting content and/or defamation;” therefore, the understanding of this term is subjective to the victim. Article 27 also includes the phrase "no rights," suggesting that victims' legal rights in response to defamation are limited. Even so, the Information and Electronic Transactions Law (ITE Law - Undang-Undang Informasi dan Transaksi Elektronik) itself does not provide a detailed explanation of these elements. The results found in this study are an objective criteria to assess whether electronic information or electronic documents which can be qualified as defaming. This study argues that defamation occurs if: (a) information or documents are built based on the clarity of the insulted person's identity; (b) the purpose of words is deemed insulting; (c) defamation is addressed to natural person or legal person (d) the content and context of each case, and (e) the allegations. In addition, a person is said to have the right to commit criminal defamation if carried out in the public interest and by being forced to defend himself.
Keywords: Criminal Defamation, Electronic Media, Indonesia
Análises de cumarinas em derivados de citrus utilizando cromatografia gasosa de alta resolução com sistemas de detecção por ionização de chama e espectrometria de massas
Authors: Vila Nova Paulo César Cavalcante , Vilegas Janete Harumi Yariwake , Lanças Fernando Mauro , De Arruda Eduardo José , De Oliveira Lincoln Carlos Silva 
Published: September 2019

As plantas cítricas, em especial a laranja, possuem grande importância para a economia brasileira, com destaque à região Sudeste do país. Os óleos essenciais de Citrus constituem um dos mais importantes grupos de matérias primas para várias indústrias, principalmente as de alimentos, farmacêuticas e de perfumaria. Na área de alimentos, o óleo essencial de laranja é usado para realçar o “flavor” do suco e exportado para o exterior, mais especificamente para os Estados Unidos (principal consumidor). Neste trabalho desenvolveu-se uma metodologia analítica para identificação e quantificação de cumarinas em derivados de plantas cítricas (óleos, ceras) utilizando-se técnicas cromatográficas tais como cromatografia gasosa de alta resolução com sistema de detecção por ionização de chama (HRGC-FID) e sistema de detecção por espectrometria de massas (HRGC-MS). Os resultados obtidos na análise qualitativa utilizando o sistema HRGC-MS empregando o monitoramento do íon seletivo (SIM) indicaram a presença de cumarina nas amostras de óleo essencial e na amostra de cera foi detectada a presença de cumarina e de psoraleno. As análises quantitativas empregando os métodos do padrão externo, padrão interno e adição de padrão apresentaram bons resultados, em especial o método do padrão interno, o qual apresentou maior repetibilidade.
Silêncio, eficiência e eficácia nas administrações municipais brasileiras
Authors: Corralo Giovani Da Silva 
Published: September 2019

Este trabalho científico objetiva refletir sobre a eficiência e eficácia nas administrações municipais, especialmente com a aferição de efeito ao silêncio administrativo no exercício da polícia administrativa. Utiliza-se o método hipotético-dedutivo. Para tanto, estuda-se a eficiência e eficácia na administração pública brasileira a fim de compreender a sua normatividade. Segue-se com a análise do silêncio e seus efeitos, como também da manifestação do início de atividades, com foco nas licenças para construir e de localização e funcionamento, ambas marcadas por elevada vinculação. Conclui-se pela possibilidade da aferição do efeito de deferimento tácito ao silêncio da administração para as licenças de construir e de localização e funcionamento, como também a manifestação de início de atividades no último caso, a conduzir a maior eficiência e eficácia para a administração pública, o que deve estar normatizado na legislação local.
Dynamic changes and genotypic variations of nitrogen concentration and remobilization for 20 tea plant (Camellia sinensis) cultivars throughout growing seasons
Authors: Zhang Yange , Ye Xiangsheng , Zhang Xinwan , Huang Wei , Zhao Hua , Ni Dejiang 
Published: September 2019

Abstract
Background: Tea plant ( Camellia sinensis ) is an evergreen perennial plant and characterized by a high nitrogen (N) requirement. There are roundly bud sprouting and leaves development for plucking and pruning annually, leading to continuous and substantial amount of N removal. Appropriate level of N application is closely related with high yield and top quality, therefore understanding the underlying mechanism is very crucial for development of optimized tea garden management practices according to genotypes’ requirement. Results: This study aimed to assess variation for dynamic N concentration, N remobilization efficiency (NRE) and N utilization efficiency (NUtE) changes during growing seasons among 20 tea plant cultivars at sufficient N level. The average N concentration varied between 31.05 and 44.2 g kg -1 in one bud with two leaves, between 22.67 and 29.42 g kg -1 in leaves attached to green-red stems, between 20.79 and 24.57 g kg -1 respectively. The dynamic changes of N concentration represented different profiles of ‘S’, ‘U’ and ‘S-like’-shape respectively. Specific NRE defined here is dependent on the development rounds and accompanied with N fluxes between leaves compartments. Nevertheless, the rates and order of N remobilization were inconsistent among genotypes during the entire growing seasons, which might be affected by the amount of N requirement and managed at whole plant level. The dynamic changes of average NUtE among cultivars followed an ‘S’-shape. NUtE addressed here was special for harvestable part and lower NUtE is highly associated with tea quality. Conclusions: The result revealed the annual growing rhythm and physiological character related with N indices, which was related with the amount and optimal time for N fertilization requirement dependent on tea plant genotype. An optimized NUtE should be optimized by combination of tea garden management and breeding practices to achieve economic benefit, N use efficiency and sustainable development.
Effect of core materials for core fabrication for dental Implants on in-vitro cytocompatibility of MC3T3-E1 cells
Authors: Park Jung-Hyun , Lee Hyun , Kang Seen-Young , Kim Junesun , Kim Ji-Hwan 
Published: September 2019

Abstract
Background: Despite the wide use of dental materials for CAD/CAM system in prosthetic treatment, the effect of the materials, which are used as dental implants core fabricated, on cells involved in dental implant osseointegration is uncertain. This study aimed to investigate and compare the effect of single core materials used for dental implants fabricated by the dental prostheses fabrication process and the CAD/CAM milling method on MC3T3-E1 cells. Methods: The materials used for prostheses restoration in this experiment were Porcelain Fused Gold (P.F.G), Lithium disilicate glass ceramic (LiSi 2 ), Zirconia (ZrO 2 ), Nickel-Chromium (Ni-Cr) and Cobalt-Chromium (Co-Cr). MC3T3-E1 cells were cultured and used, the cell adhesion and morphology were observed and analyzed using confocal laser scanning microscopy (CLSM). Methoxyphenyl tetrazolium salt (MTS) and alkaline phosphatase (ALP) assay were used to observe the cell proliferation and differentiation. Results: CLSM revealed irregular cell adhesion and morphology and the filopodia did not spread in the Ni-Cr specimen group. Significantly high cell proliferation was observed in the ZrO 2 specimen group. The LiSi 2 specimen group presented significantly high cell differentiation. Intergroup comparison of cell proliferation and differentiation between the Ni-Cr specimen group and all other specimen groups showed significant differences (p < .05). Conclusion: Cell proliferation and differentiation were observed from the cores, which were fabricated with all specimen groups on cytocompatibility except the Ni-Cr specimen group.
Identification of novel biomarkers and prognostic value of the location (head, body, or tail) of pancreatic cancer
Authors: Han Shuwen , Yang Xi , Xu Jiamin , Wu Wei , Liu Jin 
Published: September 2019

Abstract
Objective : This study was designed to identify the differentially expressed mRNA, microRNA (miRNA), and long non-coding RNA (lncRNA) and their functions in pancreatic cancer (PC).

Methods: The expression data of PC and normal samples were downloaded from the GEO database. The expression data of pancreatic head (H), body (B), and tail (T) were downloaded from the TCGA database. After data preprocessing, the differential analyses between PC vs. Normal, H vs. B, H vs. T, and T vs. B were performed. Overlapping genes between PC vs. Normal and the different locations (the union of genes among T vs. B, T vs. H, and B vs. H) were selected. The competing endogenous RNAs (ceRNA) network was constructed based on co-expression analysis and prediction of targets, followed by functional enrichment analysis. Construction of an mRNA prognosis risk model and screening of prognostic factors were performed using Cox univariate/multivariate regression analysis, followed by Nomogram model construction. Finally, the gene-drug interactions were predicted for the DE-mRNA.

Results: A five-mRNA prognostic model (GRHL2+CACNA1A+GRM1+UPK1B+PKHD1) was constructed, and the risk score was relatively increased with the increased expression of the GRHL2, PKHD1, and UPK1B, and the decreased expression of CACNA1A and GRM1. Compared with pancreatic body/tail cancer, the expression of GRHL2 was increased, while the expression of CACNA1A and GRM1 was decreased in pancreatic head cancer. LncRNA AC006369.2-miR-146a-5p-CACNA1A/GRM1 was a regulatory axis in the ceRNA network. Verapamil was predicted to be an antagonist of CACNA1A.

Conclusion: Our results provide a new direction for the accurate diagnosis and treatment of PC and for investigating the mechanism of PC.
Primary fallopian tube carcinoma: a single-institution retrospective study of 57 cases
Authors: Ma Zhihua , Gao Li , Li Han , Xue Yan 
Published: September 2019

Abstract
Background In order to identify the characteristics and factors affecting the treatment and prognosis of primary fallopian tube cancer(PFTC),we analyzed the clinical profile of PFTC in the past 10 years in our hospital, which is center in Western China. Methods A retrospective analysis was performed on 57 patients diagnosed as PFTC at the Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xi’an Jiaotong University from past ten years. The clinical index and a Cox proportional hazards model was used for univariate and multivariate survival analyses. Results The mean age of PFTC at diagnosis was 57.35±9.01 years. Palpable pelvic and/or abdominal mass (68.4%) was the main clinical symptom. Preoperatively, 80.7% patients were misdiagnosed with ovarian cancer, and 43.8% of patients were at stage III. 26 patients were relapsed at the median of 18.5 (3-83) months. The 5-year overall survival (OS) rate was 15.4%, and the 5-year disease-free survival (DFS) was 11.5%. Additionally, univariate analysis showed that tumor stage and size of residual tumor were both related to 5-year OS and DFS. While level of serum carbohydrate antigen 125(CA125) pre-treatment was only related to DFS. The Cox proportional hazards model demonstrated that residual tumor size was the only independent factor related to both 5-year OS and DFS. Conclusions PFTC is a more common malignancy at post-menopause stage in women. The symptoms are not typical in most case and often diagnose at late clinical stage. Tumor stage, level of CA125, and residual lesion size affected the disease-free survival or/ and overall survival. Trial registration Not applicable.
Alcohol and drug use disorders among adults with ADHD: Prevalence and associations with ADHD symptom severity and emotional dysregulation.
Authors: ANKER Espen , Haavik Jan , Heir Trond 
Published: September 2019

Abstract
Background High risk of substance use disorders (SUD) in people with ADHD calls for exploratory research. The aim of this study was to estimate the prevalence of alcohol use disorder (AUD) and drug use disorder (DUD) in a clinical sample of adults with ADHD, and to examine their association with ADHD symptom severity and emotional dysregulation (ED).Methods The study sample consisted of patients who were admitted to a private psychiatric outpatient clinic in Oslo between 2014 and 2018. Out of 612 patients diagnosed with ADHD, 585 (96.5%) agreed to participate in the study. ADHD was diagnosed according to DSM-5 criteria. AUD and DUD were diagnosed using the Mini International Neuropsychiatric Interview (M.I.N.I.). ADHD severity was assessed by the Adult ADHD Self Report Scale (ASRS). Emotional Dysregulation (ED) was assessed by the eight-item version of Barkley’s Current Behavior Scale - Self Report (CBS-SR).Results The 12-month prevalence of AUD and DUD was 5.3% and 13.7%, respectively. The lifetime prevalence was 12.0% for AUD and 27.7% for DUD. A history of DUD, but not AUD, was positively associated with hyperactivity-impulsivity ADHD core symptoms, as well as ED.Conclusions The prevalence of lifetime DUD among patients with ADHD is high and associated with higher levels of hyperactivity-impulsivity symptoms, as well as ED. It is important to consider comorbid DUD in adult ADHD patients, particularly among individuals with high levels of hyperactivity-impulsivity ADHD core symptoms or ED.
Effect of prior receipt of antibiotics on the pathogen distribution: a retrospective observational study on 27 792 patients
Authors: Li Leiqing , Xu Lingcheng , Zhu Rongsheng , Song Jiaojiao , Wang Xuanding 
Published: September 2019

Abstract
Background There have been no systematic studies of microbiological differences before and after antibiotics treatment. The aim of this study was to evaluate the effect of prior receipt of antibiotics on the microorganism distribution.Methods A retrospective, observational study patients was conducted in a 3,200-bed tertiary, referral, teaching hospital in eastern China. During a 2-year period, all hospitalized patients treated with antimicrobial agents were enrolled in this study. Among 48,692 patients evaluated, the 27,792 (57.1%) who were sampled within two days before or after administration of the first dose of antimicrobial agents were included. Distribution of clinical specimens and the microorganism were compared between before and after antibiotic drug treatment groups.Results Compared to specimens taken after antibiotics exposure, specimens taken before antibiotics exposure had a higher proportion of blood and urine specimens and a higher culture positive rate (all P <0.001). Higher percentages of Staphylococcus aureus (9.9% vs. 8.5%, P =0.041), non-fermenting bacteria (27.7% vs. 19.9%, P <0.001), and fungi (7.9% vs. 3.6%, P <0.001) were isolated from the group after antibiotics exposure, while the percentages of Streptococcus spp. (4.8% vs. 2.7%, P <0.001), Haemophilus influenzae (2.3% vs. 0.8%, P <0.001), and Moraxella catarrhalis (0.7% vs. 0.1%, P <0.001) were higher in the group before antibiotics exposure. Further analysis found significant differences or different rank orders of microbes derived from respiratory secretions, blood or urine samples, but no statistical difference was found for microbes isolated from body fluid specimens between the two groups.Conclusions The outcome revealed that antibiotic-insensitive organisms such as non-fermentative bacteria and fungi were more frequently isolated after antibiotics exposure. However, this trend might be specimen dependent and was not obvious in body fluid specimens.
Efficacy and tolerability of DAAs in HCV-monoinfected and HCV/HIV-coinfected patients with psychiatric disorders
Authors: de Gennaro Nicolò , Diella Lucia , Monno Laura , Angarano Gioacchino , Milella Michele , Saracino Annalisa 
Published: September 2019

Abstract
Background few data are available regarding use of direct antiviral agents (DAAs) for chronic hepatitis C in psychiatric patients. The aim of the study is to assess safety and outcome of DAAs in patients with psychiatric comorbidities.Methods this retrospective, observational, single-centre study enrolled patients treated with psychiatric drugs who initiated DAAs between 2015-2018. Patients were classified into two groups: A (on anxiolitycs/antidepressant) and B (on antipsychotics). Week-12 sustained virological response (SVR-12) and adverse events (AEs) were evaluated.Results 144 patients were included (A:101; B:43). Patients were 49.3% males, mean age 60 years (SD±13.5); 31.9% cirrhotic; 125 (86.8%) HCV-monoinfected and 19 (13.2%) HIV/HCV-coinfected. Twenty patients (13.8%) required a change of psychiatric therapy before DAAs-initiation. Overall, SVR-12 was achieved in 88.2% of subjects in intention-to-treat(ITT)-analysis. Lower SVR rates were observed in group B vs A (79% vs 92%, p=0.045) and in those changing psychiatric drugs vs others (30% vs 8%, p=0.015). At least one AE occurred in 60 patients (41.6%), including 10 SAEs, leading to 3 discontinuations. AEs were more frequently reported in group A (p=0.015).Conclusions the study confirms effectiveness and safety of DAA-based treatment also in this special population, even if a careful evaluation of history and drug-drug interactions is warranted.
High Prevalence of 16S rRNA methylase genes High Prevalence of 16S rRNA methylase genes Among Carbapenem-resistant Hypervirulent Klebsiella pneumoniae Isolates in China
Authors: Liao Wenjian , Li Dan , Wei Dan Dan , Du Fang-lin , Long Dan , Zhang Wei , Liu Yang 
Published: September 2019

Abstract
Background : the existence of 16S rRNA methylase genes would increase treatment difficulty of patients infected with CR-hvKP strains, this study was aimed to testify the prevalence of the 16S rRNA methylase genes genes in the CR-hvKP strains in China.Methods : Thirty-nine carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) isolates collected from a Chinese hospital during the whole year of 2018 were evaluated to characterize the prevalence of 16S rRNA methylase genes. Results : In tatal 66.7% (26/39) of the CR-hvKP isolates were found to carry 16S rRNA methylase genes, and the most frequently detected gene was armA (11,42.3%), followed by rmtB (8,30.8%),and 7 CR-hvKP strains were found to carry both armA and rmtB (26.9%). All the clinical isolates were found to carry at least one carbapenemase gene,with KPC-2 (79.5%,31/39), NDM-1 (10.3%,4/39), and cocarrying KPC-2 and NDM-1 (10.3%,4/39). A total of 89.7% (35/39) isolates carried ESBL genes, including 61.5% (24/39) blaSHV-1 ,71.8% (28/39) blaTEM-1 and 89.7% (35/39) blaCTX-M-1 4. All except four isolates (89.7%,35/39) harbored PMQR genes,with qnrS (82.1%,32/39), aac(6’)-Ib-cr (79.5%,31/39), qnrB (2.6%,1/39).All the 16S rRNA methylase genes-positive CR-hvKP strains were firstly found to cocarry carbapenemase genes, ESBL genes and PMQR genes simultaneously. The most prevalent virulence genes were rmpA2 and entB (100%, 39/39),followed by silS (97.4%, 38/39), ybtS (94.9%, 37/39), iutA (92.3%, 36/39), kpn (92.3%, 36/39), rmpA (87.2%, 34/39), terW (84.6%, 33/39), aerobactin (23.1%, 9/39), repA (17.9%, 7/39), magA (10.3%, 4/39), kfuB C (10.3%, 4/39), w ca G (10.3%, 4/39), allS (10.3%, 4/39). Multilocus sequence typing (MLST) analysis assigned the 39 CR-hvKP isolates into 4 sequence types (STs), with ST11 encompassing 79.5% of the strains. Pulsed field gel electrophoresis (PFGE) typing showed that strains closely related by MLST clustered in major PFGE clusters, of which cluster A accounts for 31 ST11 isolates.The analysis of the transconjugants showed a high-level aminoglycoside resistance and a popular cotransfer of bla KPC-2 with the 16S rRNA methylase genes.Conclusions : 16S rRNA methylase genes are highly prevalent in CR-hvKP clinical isolates especially for ST11, it is therefore critical to continuously monitor the 16S rRNA methylase-producing CR-hvKP epidemiology and minimize potential risks from aminoglycoside -resistant CR-hvKP.