bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Bukti Digital Pada Discord Browser Menggunakan Teknik Live Forensic Dengan Metode NIST SP 800-86
Authors: Hendrawan Mohammad Yan Fikri , Subektiningsih Subektiningsih , Hadinegoro Arifiyanto 
Published: November 2024

Platform komunikasi sangat beragam, sebagai contoh adalah Discord. Pengguna memanfaatkan platform Discord untuk chat dan berbagi konten. Namun, dalam platform Discord sering terindikasi distribusi konten tidak layak, konten yang tidak sesuai dengan peraturan dari Discord. Hal ini dapat memicu kasus cybercrime seperti; sexual harassment, cyber bullying, dan hacking. Dalam investigasi tindak kejahatan memerlukan bukti digital untuk dianalsis. Tantangan yang dialami berupa data digital yang telah dihapus melalui platform komunikasi yang digunakan. Tujuan dalam penelitian ini adalah untuk menganalisis bukti digital berupa pesan teks serta gambar atau foto yang telah dihapus pada room chat platform Discord berbasis website. Teknik yang digunakan adalah live forensic menggunakan Metode NIST SP 800-86. Fokus dalam penelitian ini adalah membandingkan bukti digital yang diperoleh dari berbagai browser yang digunakan untuk mengakses Discord. Eksperimen melalui penyusunan scenario dengan mengakses Discord melalui berbagai browser, antara lain; Google Chrome, Mozilla Firefox, dan Microsoft EDGE. Tahap analisis menggunakan forensic tools Chrome Cache View, MZ Cache View, FTK Imager, dan Autopsy. Bukti digital berupa pesan teks dan gambar yang telah dihapus dari Discord dengan diakses menggunakan ketiga browser tersebut dapat ditemukan menggunakan kombinasi forensic tools tersebut. Informasi lain yang dapat diperoleh adalah username dan time dari chat pada Discord. Dalam analisis bukti digital kombinasi penggunaan forensic tools dapat dilakukan mendapatkan informasi lengkap sebagai pembuktian insiden. Penelitian selanjutnya dapat dikembangkan dengan teknik yang berbeda untuk memperoleh bukti digital yang lebih bervariasi.
नाटकको चौथो चरण कथामा रसविधान
Authors: लुइटेल Luitel गोविन्दप्रसाद Govindaprasad 
Published: November 2024

प्रस्तुत आलेख रसविधानको विश्लेषणमा आधारित छ । रस पूर्वीय साहित्यशास्त्रअन्तर्गतको महŒवपूर्ण सिद्धान्त हो । साहित्यिक रचनाको पठनबाट प्राप्त आनन्द वा भावको आस्वादनलाई साहित्यमा रस भनिन्छ । साहित्यमा रसको विशिष्ट प्रयोगबाट पाठकहृदय आह्लादित हुन्छ । यस अध्ययनमा ‘नाटकको चौथो चरण’ कथामा कुन रसको प्रयोग के कसरी भएको छ भन्ने कुराको निरूपण यही रससिद्धान्तका आधारमा गरिएको छ । यस अध्ययनमा विवेच्य कथामा रस सामग्रीका रूपमा आएका विभाव, अनुभाव, सञ्चारीभाव र स्थायी भावको बेग्लाबेग्लै विश्लेषण गरी निष्कर्ष प्रस्तुत गरिएको छ । यसका लागि प्राथमिक सामग्रीका रूपमा ‘नाटकको चौथो चरण’ कथालाई लिइएको छ । सामग्री विश्लेषणमा गुणात्मक पद्धतिको अवलम्बन गरिएको छ भने विश्लेषणको ढाँचामा रसविधानका सूचक निर्माण गरी त्यसकै आधारमा विश्लेषण गरिएको छ । विवेच्य कथामा नैनबहादुरकी श्रीमतीको मृत्युको हृदयविदारक घटनाको उचित विन्यासबाट करुण रसलाई परिपाक गराइएको छ । यस कथामा करुण रसको अभिव्यक्ति पाठकहृदयलाई विदारण गर्न सक्षम भएकाले त्यो प्रबल रूपमा आएको छ । विभाव, अनुभाव सञ्चारीभावको उचित संयोजनबाट शोक स्थायीभाव उद्बुद्ध भई करुण रस परिपाक भएकाले रसविधानका दृष्टिले प्रस्तुत कथा महŒवपूर्ण र उत्कृष्ट रहेको निष्कर्ष यस अध्ययनबाट प्राप्त भएको छ
विश्वेश्वरप्रसाद कोइरालाका कथात्मक सङ्कथनको प्रकारता
Authors: न्यौपाने Neupane भुवन  Bhuwan 
Published: November 2024

नेपाली कथा लेखनको परम्परामा मनोविश्लेषणात्मक यथार्थवादको प्रवर्तन गर्ने कथाकार विश्वेश्वरप्रसाद कोइरालाले आप्mना कथामा नेपाली सामाजिक सन्दर्भलाई प्रस्तुत गर्दै पात्रको मनस्थितिको विश्लेषण गरेका छन् । उनका प्रकाशित छब्बिस ओटा कथामा उच्च, मध्यम र निम्न वर्गीय पात्रको मनोदशाको उद्घाटन गरिएको छ । उनले यौन मनोविज्ञानमा आधारित कथा लेख्दा नारी मनोदशाको विश्लेषणमा ज्यादा रुचि राखेका छन् भने यौनेतर विषयमा आधारित कथामा उनले बढी मात्रामा पुरुष पात्रको मनोदशाको उद्घाटनमा केन्द्रित भएका छन् र यस्ता कथामा नेपालको वि.सं. १९९५ देखि २०१९÷२० सम्मका सामाजिक, सांस्कृतिक, राजनैतिक विषय समेटिएका छन् । उनका कथाको आन्तर्यमा निरङ्कुश शासन व्यवस्था, सामन्तवाद, पुरातनवाद र रुढिवादमाथि विरोध तथा विद्रोहको स्वर प्रकट गर्दै स्वतन्त्रता, समानता, नागरिक अधिकार र मानवताका पक्षमा वकालत गरिएको हुँदा पाठेतर सन्दर्भको सघनता पाइन्छ । विषयवस्तुका दृष्टिकोणबाट मात्र होइन कि शिल्पशैलीका दृष्टिकोणबाट पनि परम्परागत कथा लेखनको एकरेखीयता तथा घटनाप्रधानतालाई भङ्ग गर्दै कथाको शिल्प, संरचना र प्रस्तुतीकरणमा आधुनिक ढाँचा वा पद्धतिको प्रयोग कोइरालाका कथामा गरिएको पाइन्छ ।
Detection of Traffic Anomalies Based on Their Frame Wavelet Transformations Processing
Authors: Zhdanova I. M. , Dvornikov S. S. , Dvornikov S. V. 
Published: November 2024

Relevance. The active transition to a massive digital infrastructure based on Internet of Things (IoT) technology has brought telecommunications networks to the level of dominant information resources. The one-time increase in the number of existing Internet services is inextricably linked to the growing variety of network anomalies on telecommunications equipment. In turn, existing methods of detecting network threats do not allow timely assessment of network traffic, which is characterized by a large number of parameters, and the detected anomalies from external interference do not have pronounced patterns. The purpose of the study is to increase the efficiency of detecting traffic anomalies based on the results of processing its frame wavelet transform. The scientific task is to develop scientific and methodological approaches that allow effective analysis and timely detection of anomalies in network traffic. A comparative review of search methods for detecting network traffic anomalies, algorithms for detecting uncontrolled anomalies, traffic analysis methods based on local emission factor, binary trees, optical emission spectroscopy. Decision. The results of the study of the possibility of detecting anomalies in the bitstream traffic based on the results of its multiple-variable transformation in the Haar wavelet basis are considered. The choice for further processing of the coefficients of the traffic decomposition matrix along the time shift variable is justified. It is proved that multiple-scale transformations not only increase the structural differences in traffic, but also open up the possibility of localization of anomalies that caused these differences. The scientific novelty of the work is determined by the author's approach to detecting network traffic anomalies during the transition from the direct representation of a signal in the form of its discrete samples to coefficients formed from the matrices of its wavelet transformations, and, as a result, increasing its contrast with other signals with a similar structure. Theoretical significance. The necessity and sufficiency of using wavelet coefficients instead of time samples of signals in the basis of the parent wavelet from the matrix of the generated frame is proved. The relationship between the Hurst indicators and the coefficients of the cross-correlation functions has been established. Practical significance. The results obtained in the work, in the future, can be used in the construction of models for evaluating network traffic in conditions of deliberate, as well as methods for searching and synthesizing effective methods of protection against them.
Peran Digital Marketing pada UMKM dengan Prinsip-prinsip Syariah
Authors: Awa Awa , Safari Apay , Riyanti Anti 
Published: November 2024

The rapid development of technology has greatly changed the marketing landscape in the world, where marketing methods that were previously completely traditional and conventional have now been integrated into the digital world. Understanding and awareness of the importance, role and influence of digital marketing in micro, small and medium enterprises (MSMEs) is still low. Its implementation is still considered not that important, on the grounds that the business being run is not a large business that requires digital marketing. Including its implementation of sharia principles is still very minimal. Research that explores the role of digital marketing in MSMEs with sharia principles in a comprehensive manner has never been conducted before. The aim of the research is to explore the role of digital marketing in MSMEs with sharia principles. The method used is library research, using critical analysis techniques. The results of research regarding the role or impact or influence of digital marketing in MSMEs with sharia principles are on the following 15 things: (1) facilitate access to information; (2) marketing products; (3) become a superior product; (4) healthy competition; (5) expanding target/market share; (6) expanding geographic reach; (7) building trust and reputation; (8) purchasing decisions; (9) increase in income; (10) increase in sales; (11) increasing business performance; (12) business sustainability and success; (13) application of Islamic marketing ethics; (14) development of halal label MSMEs; and (15) development of MSMEs through cooperatives.
Efficacy and safety of RC48-ADC in HER2-positive and HER2-low metastatic breast cancer: a multicenter, real-world study
Authors: Qu Fei , Lu Rongrong , Wu Xinyu , Liu Qian , Zha Mengyao , Li Huihui , Yuan Yuan , Han Zhengxiang , Cai Dongyan , Huang Xiang , Yin Yongmei , Li Wei 
Published: November 2024

BackgroundA standard treatment recommendation for third-line and subsequent treatments for advanced HER2-positive breast cancer is still missing, especially for low HER2 expression. Nevertheless, there is evidence that these patients might benefits from antibody-drug conjugates (ADCs) treatment. Therefore, this study aimed to evaluate the clinical efficacy, safety, and factors affecting efficacy of Disitamab Vedotin (RC48) for treating HER2-positive and HER2-low metastatic breast cancer (MBC) in the real-world setting.MethodsA retrospective study at five clinical sites was conducted in China, enrolling MBC patients treated with RC48 from July 01, 2021 and May 31, 2023. Patient demographics, treatment patterns, and adverse events (AEs) were recorded and analyzed.ResultsA total of 154 patients were included: 104 (67.53%) patients with HER2-positive and 50 (32.47%) patients with HER2-low MBC. The median progression-free survival (mPFS) was 5.06 months. The objective response rate (ORR) and disease control rate (DCR) were 36.36% and 68.83%, respectively. HER2-positive patients exhibited a mPFS of 5.93 and an ORR of 41.35%. In contrast, patients with low-HER2 had a mPFS of 4.28 months and an ORR of 26.00%. The most common AEs included neutropenia (54.55%), increased AST (53.25%), leukopenia (51.95%), and fatigue (43.51%), mostly graded mild to moderate (grade 1-2).ConclusionsThis extensive study in China demonstrated that RC48 has excellent therapeutic potential for both HER2-positive and HER2-low MBC with a favorable safety profile. The study also suggests that combination therapy significantly boosts efficacy beyond monotherapy, indicating a promising avenue for future ADC development.
Lactate dehydrogenase A is a diagnostic biomarker associated with immune infiltration, m6A modification and ferroptosis in endometrial cancer
Authors: Huang Yan , Tang Weichun , Chen Liping 
Published: November 2024

BackgroundLactate dehydrogenase A (LDHA) has been confirmed as a tumor promoter in various cancers, but its role in endometrial cancer remains unclear.MethodsThe Cancer Genome Atlas (TCGA), quantitative real-time polymerase chain reaction and the Human Protein Atlas were utilized to analyzed the LDHA expression in EC. The LDHA levels of patients with different clinical features were compared based on the TCGA cohort. The Genome Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis of LDHA-related genes were conducted by R language. The influence of LDHA knockdown on cell proliferation, apoptosis, migration and invasion was detected by in vitro experiment. The relationship between LDHA expression and immune infiltration was explored by Tumor Immune Estimation Resource 2.0 and Gene Expression Profiling Interactive Analysis. The association of LDHA level with N6-methyladenosine (m6A) modification and ferroptosis was investigated based on the TCGA-UCEC and the GEO cohort.ResultsThe LDHA was overexpressed in EC tissues and EC cell lines, and had high predictive accuracy for the EC diagnosis. The LDHA level was associated with age, histological type, histologic grade, and radiation therapy. LDHA-related genes participated in multiple biological functions and signaling pathways. LDHA downregulation significantly promoted cell apoptosis and inhibited the proliferation, migration, and invasion of EC cells. LDHA expression was connected to multiple tumor-infiltrating lymphocytes (TILs), m6A-related genes, and ferroptosis-related genes.ConclusionLDHA has the potential to work as an EC biomarker associated with TILs, m6A modification, and ferroptosis in EC.
Identification of immune-associated genes for the diagnosis of ulcerative colitis-associated carcinogenesis via integrated bioinformatics analysis
Authors: Cang Xueyu , Li Ning , Qi Jihan , Chen Hongliang , Xing Hui , Qiu Jiawei , Tian Yingying , Huang Shiling , Deng Pengchao , Gao Feiyang , Chaulagain Ram Prasad , Ullah Ubaid , Wang Chunjing , Liu Lina , Jin Shizhu 
Published: November 2024

BackgroundUC patients suffer more from colorectal cancer (CRC) than the general population, which increases with disease duration. Early colonoscopy is difficult because ulcerative colitis-associated colorectal cancer (UCAC) lesions are flat and multifocal. Our study aimed to identify promising UCAC biomarkers that are complementary endoscopy strategies in the early stages.MethodsThe datasets may be accessed from the Gene Expression Omnibus and The Cancer Genome Atlas databases. The co-expressed modules of UC and CRC were determined via weighted co-expression network analysis (WGCNA). The biological mechanisms of the shared genes were exported for analysis using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. To identify protein interactions and hub genes, a protein-protein interaction network and CytoHubba analysis were conducted. To evaluate gene expression, external datasets and experimental validation of human colon tissues were utilized. The diagnostic value of core genes was examined through receiver operating characteristic (ROC) curves. Immune infiltration analysis was employed to investigate the associations between immune cell populations and hub genes.ResultsThree crucial modules were identified from the WGCNA of UC and CRC tissues, and 33 coexpressed genes that were predominantly enriched in the NF-κB pathway were identified. Two biomarkers (CXCL1 and BCL6) were identified via Cytoscape and validated in external datasets and human colon tissues. CRC patients expressed CXCL1 at the highest level, whereas UC and CRC patients showed higher levels than the controls. The UC cohort expressed BCL6 at the highest level, whereas the UC and CRC cohorts expressed it more highly than the controls. The hub genes exhibited significant diagnostic potential (ROC curve &gt; 0.7). The immune infiltration results revealed a correlation among the hub genes and macrophages, neutrophils and B cells.ConclusionsThe findings of our research suggest that BCL6 and CXCL1 could serve as effective biomarkers for UCAC surveillance. Additionally, they demonstrated a robust correlation with immune cell populations within the CRC tumour microenvironment (TME). Our findings provide a valuable insight about diagnosis and therapy of UCAC.
The effect of alexithymia on self-perceived aging among community-dwelling older adults with multiple chronic conditions: the mediating role of maladaptive cognitive emotion regulation strategies
Authors: Xu Jianou , Shang Bin , Zhang Jun , Luo Caifeng , Bian Zekun , Lv Fei , Yang Zhengxia 
Published: November 2024

ObjectivesThis study investigated the mediating role of maladaptive cognitive emotion regulation strategies in the relationship between alexithymia and self-perceived aging among older adults.MethodsWe surveyed 478 Chinese community-dwelling older adults from November 2022 to May 2023. The Toronto Alexithymia Scale (TAS-20), Cognitive Emotion Regulation Questionnaire (CERQ), and Brief Aging Perceptions Questionnaire (B-APQ) were used. Correlation analyses, multiple linear regression analysis, and structural equation modeling were performed.ResultsThe average age of participants was 71.52 ± 7.80 years, and the number of chronic diseases was distributed as follows: 270 (56.49%) had 2 disease conditions, 156 (32.64%) had 3 disease conditions, and 52 (10.88%) had 4 disease conditions or more. Scores for alexithymia 57.83 ± 10.19; maladaptive cognitive emotion regulation strategies 49.63 ± 10.65; and self-perceived aging 58.74 ± 10.23. Alexithymia and maladaptive cognitive emotion regulation strategies were positively correlated with negative self-perceived aging (r=0.665 and r=0.673, respectively), explaining 51.8% of the variance in self-perceived aging. Structural equation modeling results showed that alexithymia had a direct effect (of 0.368) on self-perceived aging, accounting for 44.1% of the total effect. Maladaptive cognitive emotion regulation strategies partially mediated the relationship, with a mediation effect of 0.386, accounting for 51.8% of the total effect.ConclusionThese findings suggest that addressing maladaptive cognitive emotion regulation strategies can help reduce negative self-perceived aging in elderly individuals with multiple chronic conditions, particularly among those with alexithymia.
Knowledge, attitudes, and practices of dietary management among patients with rheumatoid arthritis in China
Authors: Li Xueyong , Liu Ju , Yu Jie , Dong Liang 
Published: November 2024

BackgroundThis study aims to assess the knowledge, attitudes, and practices (KAP) regarding dietary management among patients with rheumatoid arthritis (RA).MethodsA cross-sectional survey was conducted at JiuJiang NO.1 People’s Hospital from November 2023 to May 2024. Data were gathered using structured questionnaires that solicited demographic information and measured KAP scores related to dietary management in RA patients.ResultsThe survey yielded 504 valid questionnaires. Of the respondents, 306 (60.71%) had a Body Mass Index (BMI) within the optimal range of 18.5–23.9 kg/m2. The mean scores for knowledge, attitude, and practice were 10.13 ± 3.58 (possible range: 0–22), 31.38 ± 2.38 (possible range: 9–45), and 4.46 ± 2.30 (possible range: 0–12), respectively. Correlation analysis revealed significant relationships between knowledge and practice (r = 0.294, p &lt; 0.001) as well as between attitude and practice (r = 0.178, p &lt; 0.001). Multivariate logistic regression showed that knowledge score (OR = 1.165, 95% CI: [1.078, 1.259], p &lt; 0.001) was independently associated with proactive practice. The structural equation model (SEM) results showed that knowledge had direct effects on attitude (β = 0.291, p &lt; 0.001) and practice (β = 0.188, p &lt; 0.001). Meanwhile, attitude had a direct impact on practice (β = 0.081, p = 0.045).ConclusionThis study indicates that patients with RA generally demonstrate inadequate knowledge but hold positive attitudes toward dietary management, despite relatively inactive practices in implementing such dietary changes. Healthcare providers should prioritize educational interventions that not only enhance patient understanding but also actively support the implementation of dietary management strategies in clinical settings.
Case report: A rare case of oral sebaceous carcinoma in the upper lip
Authors: Katib Yousef , Essatari Murad 
Published: November 2024

Sebaceous carcinoma (SC) is a rare aggressive malignant tumor that originates in the adnexal epithelium of the sebaceous gland. While occurrences on the lips are extremely uncommon, there have been a few reported cases in the literature. Our case involves a 47-year-old smoker male who presented with a painless, non-mobile lesion on his upper lip that had been present for 12 months. Upon clinical examination, an ulcerated, exophytic, and irregularly shaped mass was observed on the upper lip. No other intraoral lesions were found. An incisional biopsy was performed, revealing a malignant tumor with a nodular pattern consisting of basaloid cells with obvious sebaceous differentiations and frequent mitoses. The neoplastic cells tested positive for broad-spectrum cytokeratin (AE1-AE3), epithelial membrane antigen (EMA), and P53, while testing negative for S-100 and carcinoembryonic antigen (CEA). Based on these results, a diagnosis of SC of the upper lip was made. This case report and review aimed to describe the histogenesis, unique clinicopathological features, and current treatment options for SC.
Moderating Impact of Leader’s Role in Promoting Islamic Work Ethics between the Relationship of Procedural and Distributive Justice on Employee Commitment
Authors: Malik Fozia , Waheed AJMAL 
Published: November 2024

Objective. The basic objective of this research is to study the moderating impact of leader’s role in promoting Islamic work ethics between the relationship of procedural and distributive justice on employee commitment.Method. For this purpose, employees of hospitality industry was selected as a targeted population. The survey was administered by distributing 300 questionnaires among the employees by using convenience sampling technique, 268 questionnaires were returned out of which 11 questionnaires were not properly filled, so the sample size for this research was 257 which is showing 85% response rate. For moderation analysis Preacher and Hayes method was used through Process Macros.Results. The findings have shown that these relations outcome was only originated among those with strong implementation of leader’s role in promoting Islamic work ethics. Hence, leader’s role in promoting Islamic work ethics strengthen the relationship among procedural and distributive justice on employee commitment. Results of this study opened novel, innovative and practical approach into the current debate of the leader’s role in promoting Islamic work ethics.Implications. The originality of current work is that the concept of Islamic work ethics is studied many times previously but the leader’s role in promoting Islamic work ethics is a new phenomenon. As being of Muslims the leaders must promote Islamic work ethics at their work life. Therefore, from the avenue of present research future researchers can gain new insight.