bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell‐Sensing Analogue Nanopore for Rapid Detection of Protein‐Related Targets
Authors: Dai Jun , Hu Yuxin , Liu Weiyong , Liu Hong , Wang Shixuan , Xia Fan , Lou Xiaoding 
Published: November 2024

AbstractNanopores offer significant advantages in biosensing. Conventional nanopore sensors require probe modification within the pore, and there are two major obstacles: inhomogeneity of probe modification within the pore, and distortion of the detection signal due to the uncontrollable dynamics of the target within the pore. Here, we constructed a cell‐sensing analogue nanopore (CeSa‐nanopore), by coating the outer surface of the nanopore with cell membrane. The inhomogeneity of probe modification and the uncontrollable kinetics of target‐probe binding were also addressed. Specific cells are selected to prepare CeSa‐nanopore, for example, cells with high expression of angiotensin‐converting enzyme 2 (ACE2) are used to achieve the detection of SARS‐CoV‐2. When SARS‐CoV‐2 binds to CeSa‐nanopore the surface potential changes, causing a change in the ionic current, thus enabling its detection with a detection rate of 100 %. In addition, the detection of different proteins, such as follicle‐stimulating hormone (FSH), can be achieved by changing the cell membrane coating. The identification of cancer cells in ascites can also be achieved by utilizing homologous targeting between cancer cells. Importantly, the use of CeSa‐nanopores for the detection of these targets eliminates the need for pre‐processing and significantly reduces detection time.
Development of Benzimidazole‐Containing Thermosetting Imide Oligomers With Enhanced Thermal Stability and Adhesive Properties
Authors: Liu Caizhao , Zhang Song , Sun Mingming , Zhang Xugang , Zhao Ming , Song Caiyu , Bai Xuefeng , Liu Wenbin , Zhang Bin 
Published: November 2024

ABSTRACTIn this work, phenylethynyl‐terminated imide oligomers incorporating benzimidazole structures were synthesized and their structures were characterized using Fourier transform infrared spectroscopy (FT‐IR), X‐ray diffraction (XRD), and proton nuclear magnetic resonance (1H NMR). The solubility, curing behavior, thermal stability, thermomechanical properties, and adhesive performance were systematically evaluated. Different dianhydride structures and isomer ratios were utilized to optimize the performance of the oligomers. Thermogravimetric analysis (TGA) revealed 5% weight loss temperatures (T
5%) exceeding 520°C under both nitrogen and air atmospheres, demonstrating excellent thermal stability. Lap shear strength (LSS) testing showed that oligomers based on 4,4′‐oxydiphthalic anhydride (ODPA) exhibited superior adhesive performance, particularly at elevated temperatures. The glass transition temperature (T
g) was significantly influenced by the ratio of 3,3′,4,4′‐biphenyltetracarboxylic dianhydride (s‐BPDA) to 2,3,3′,4′‐biphenyltetracarboxylic dianhydride (a‐BPDA), with a maximum T
g of 482°C. These results underscore the potential of these oligomers for high‐performance adhesive applications in industries such as aerospace and electronics.
Science for whom? The influence of the regional academic circuit on gender inequalities in Latin America
Authors: Pradier Carolina , Kozlowski Diego , Shokida Natsumi S. , Larivière Vincent 
Published: November 2024

AbstractThe Latin‐American scientific community has achieved significant progress towards gender parity, with nearly equal representation of women and men scientists. Nevertheless, women continue to be underrepresented in scholarly communication. Throughout the 20th century, Latin America established its academic circuit, focusing on research topics of regional significance. Through an analysis of scientific publications, this article explores the relationship between gender inequalities in science and the integration of Latin‐American researchers into the regional and global academic circuits between 1993 and 2022. We find that women are more likely to engage in the regional circuit, while men are more active within the global circuit. This trend is attributed to a thematic alignment between women's research interests and issues specific to Latin America. Furthermore, our results reveal that the mechanisms contributing to gender differences in symbolic capital accumulation vary between circuits. Women's work achieves equal or greater recognition compared to men's within the regional circuit, but generally garners less attention in the global circuit. Our findings suggest that policies aimed at strengthening the regional academic circuit would encourage scientists to address locally relevant topics while simultaneously fostering gender equality in science.
Sub‐Quantum Physics and the Proton Mass
Authors: Horvath J. E. 
Published: November 2024

ABSTRACTA sub‐quantum level of elementarity, pictured as a generic thermal bath, can induce fluctuations in several measured quantities. We discuss the possible effect of the proton mass, and the connection of these fluctuations with quark states inside the proton. The quest for a substructure below quarks can be explored this way, opening a new window to the micro‐world beyond the Standard Model description.
Synthesis of MFI zeolites with hierarchical porosity by dry‐gel conversion
Authors: Kim Susung , Kim Seunghwan , Cho Hae Sung 
Published: November 2024

AbstractDry‐gel conversion (DGC), which directly converts zeolite gel into crystals by vapor, is considered a promising method for reducing amounts of zeolite precursors and easily controlling crystallization. Synthesis of MFI zeolites employing the DGC method with different amounts of tetrapropylammonium bromide (TPABr) and sodium hydroxide (NaOH) was studied to investigate the effect of TPABr and NaOH on the crystallization of MFI zeolite, with the optimal condition for synthesis found to be 0.05625 for both NaOH/SiO2 and TPABr/SiO2. Additionally, carbon black (CB) was added onto the MFI zeolite precursor gel as a hard template to generate mesopores into zeolite frameworks. The resultant MFI zeolite with CB synthesized by the DGC method showed mesoporosity, with pore size distribution similar to the particle size of CB. However, the conventional hydrothermal method could not generate mesopores in MFI zeolite due to the separation of zeolite crystals from CB templates during crystallization.
A Comprehensive Review of the Botany, Bioactive Compounds and Health Benefits of Leptospermum
Authors: Hoang Phuong Lan , Van Vuong Quan 
Published: November 2024

ABSTRACTThere is increasing interest in research and application of natural bioactive compounds due to the growing demand for functional ingredients from the pharmaceutical, cosmetic and food industries. A major challenge is finding suitable natural plant resources for the development of functional ingredients. Leptospermum, a genus of the myrtle family (Myrtaceae), is primarily native to Australia. This genus has been traditionally used for the treatment of a range of ailments, such as colds, fever, constipation, diarrhoea, skin, inflammation, stomach disorder and both internal and external pain. Manuka honey, known for its medicinal properties, is produced from the nectar of Leptospermum flowers, and the leaves of some species are used for essential oil production. Various volatiles, such as pinene, citral and citronellal, have been identified in Leptospermum essential oils. In addition, various non‐volatile compounds like leptosperin, cyanidin, quercetin, ellagic acid, delphinidin and myricetin have been isolated from Leptospermum extracts. Preliminary studies have linked Leptospermum essential oils and extracts with various health‐promoting properties, such as antimicrobial activity, antidiabetes, anticancer and anti‐Alzheimer's disease activities, revealing potential applications of Leptospermum as functional ingredients. To provide a comprehensive understanding of Leptospermum for future research and applications, this review presents an overview of its botanical features, outlines volatile and non‐volatile active molecules identified in the genus, reviews potential health benefits and finally proposes trends for future studies on Leptospermum.
Assessing Syzygium Aromaticum: From Chemical Profiling to Antioxidant, Antistaphylococcal, and Biocompatibility Attributes
Authors: Boughroud Hajar , Chgari Oumaima , Wahnou Hicham , Amrani Abdelaziz El , Faqer Othman El , Amarir Fatima , Mtairag El Mostafa , Rais Samira , Bourjilat Fatna 
Published: November 2024

ABSTRACTStaphylococcal infections challenge current treatments due to adverse effects and drug resistance, prompting the exploration of plant‐derived compounds for their promising properties. This study aimed to analyze Syzygium aromaticum essential oil (SA‐EO), aqueous (AE‐SA) and ethyl acetate (EAE‐SA) extracts for antioxidant and antistaphylococcal effects against sensitive and resistant clinical isolates. Erythrocytes were used as model cells for biocompatibility. The SA‐EO was extracted via hydrodistillation and compounds were identified using GC‐MS. The antioxidant activity was assessed using various tests, while antimicrobial activity was evaluated through disk diffusion and microdilution assays. Results showed Eugenol as the major compound in SA‐EO. The AE exhibited high phenolic and flavonoid content. SA‐EO demonstrated antioxidant activity with IC50 values of 84.63 ± 1.94 µg/mL (TAC) and 52.88 ± 1.44 µg/mL (FRAP). The AE‐SA showed scavenging effects with EC50 values of 266.52 ± 50.62 µg/mL (DPPH) and 140.67 ± 44.36 µg/mL (NO). The antistaphylococcal activity revealed significant sensitivity of SA‐EO with MIC and MBC values ranging from 0.316 to 1.266 mg/mL. SA‐EO showed low hemolytic activity even at high concentrations, indicating its safe therapeutic application. Overall, these findings highlight the potential of Syzygium aromaticum in combating multidrug‐resistant bacteria and underscore its role as a source of bioactive compounds with antioxidant properties.
When thoracic trauma does more good than harm: About an incidental finding of a gangliocytic paraganglioma of the ampulla of Vater
Authors: Rami Guizani , Ali Mseddi Mohamed , Meriem Hsairi , Sarra Saad , Alia Zehani , Mohamed Ben Slima 
Published: November 2024

Key Clinical MessageGangliocytic paragangliomas are benign neuro‐endocrine tumors of the ampulla of Vater. Their preoperative diagnosis is hampered by the low yield of biopsies and non‐specific imaging. Their management relies then on resection. But the type of resection is controversial. Radical resection is indicated in case of lymph node involvement.
Acute Myocardial Infarction in a Young 26 Years Old Patient: A Rare Sequelae of Blunt Chest Trauma
Authors: Hanif Muhammad , Malik Muhammad , Vasigh Mostafa , Shrestha Abhigan Babu , Chaudhuri Debanik 
Published: November 2024

ABSTRACTAcute myocardial infarction (AMI) is an important subset of cardiovascular disease, and a medical emergency, where timely reperfusion is needed to reduce short‐term and long‐term complications from it. AMI following blunt chest trauma is a rare but serious complication of motor vehicle accidents and should be treated promptly. We are presenting a case of 26 years‐old male, who presented to ED after a motor vehicle accident, went into cardiac arrest, and was found ST elevated MI (STEMI) on electrocardiography. Subsequently, cardiac catheterization revealed ruptured plaque in the proximal left anterior descending artery, with thrombus extending to mid‐LAD, requiring a stent placement.
Utility of Immobilized Metal Salens as Electrocatalysts: Fuel Cells and Organic Electrosynthesis
Authors: Nguyen Zachary A. , Minteer Shelley D. 
Published: November 2024

AbstractThere have been significant advancements in the electrosynthesis of fuels and organic molecules, making it an increasingly sustainable and cost‐effective alternative to traditional chemical redox reagents. Early versions of these systems faced challenges in chemoselectivity due to high applied overpotentials, which have been mitigated with the introduction of molecular electrocatalysts, like metal salens (MSalens). These MSalens reduce the required overpotentials, increase turnover numbers (TON), and have simple modularity within their ligand structure allowing for tunable selectivity. While these MSalen electrocatalysts are typically used homogeneously for engineering simplicity, downstream separations are often costly and time‐consuming. Immobilization of MSalens addresses these issues by enabling synthesis at lower potentials, achieving high selectivity, and facilitating straightforward separations. This review explores the application of MSalens in electrosynthesis and immobilized molecular electrocatalysts in organic electrosynthesis.
Describing and Mapping the Research Trend of Scientific Publications on Arrhythmogenic Right Ventricular Cardiomyopathy Across Four Decades: A Bibliometric Analysis
Authors: Mo Leitong , Sia Ching‐Hui , Lin Weiqin , Zheng Xifeng , Peng Kaiyi 
Published: November 2024

ABSTRACTObjectivesTo perform a bibliometric analysis of publications of arrhythmogenic right ventricular cardiomyopathy (ARVC) from 1981 to 2023 to summarize the current publications and explore frontiers on this topic.MethodsWe integrated the scientific publications on ARVC in the Web of Science (WOS) Core Collection database from January 1981 to September 2023, using the retrieval strategy of medical subject headings combined with keywords. We focused on articles and reviews that were published in English. Relevant information such as the journal and publisher, the title, authors, organizations, abstract, keywords, published date, and number of citations, were collected. Bibliometric analysis was performed and visualized by the R software and Microsoft Excel.ResultsThe results revealed a total of 4792 records related to ARVC from the WOS database, and 2992 original articles or reviews which were selected for bibliometric analysis. There were 79 countries and regions, 3724 research institutions, and 12 157 scholars who have published in this topic. The number of scientific publications of ARVC increased year‐by‐year, with an annual growth rate of 12.12%. We also investigated the top 10 contributing countries, organizations with affiliations, most influential researchers, highest‐cited articles, and highest‐frequency keywords. In addition, the most active areas of research on ARVC included that of fatal complications, molecular pathological mechanisms, diagnosis, therapy, and prognosis respectively according to the keywords trend analysis.ConclusionsOur study reports the publication landscape of ARVC during the past four decades based on bibliometric analysis. This study provides a deeper understanding of the published literature on ARVC.
Design and Synthesis of Unsymmetric Benzils, Quinoxalines, and Evaluations of their Anticancer Activities against Human Non‐Small Lung Cancer Cells
Authors: Hsu Ping‐Chih , Hsu Yu‐Hsin , Chang Chuan‐Hsin , Shih Tzenge‐Lien 
Published: November 2024

AbstractQuinoxaline and its derivatives exhibit a broad spectrum of biological activity, making them valuable for various therapeutic applications. However, most quinoxalines are synthetically produced due to their scarcity in nature. In this article, a series of unsymmetric benzils were synthesized and subsequently condensed with 1,2‐diaminobenzene to produce unsymmetric quinoxalines. The novel synthetic benzils and quinoxalines were evaluated for their anticancer activities against human non‐small‐cell lung cancer (NSCLC) cells harboring different gene mutations, to explore their potential as anticancer agents. Among these synthesized molecules, compound 5 g demonstrated inhibitory effects comparable to those of cisplatin.
Prediction Model for Polyneuropathy in Recent‐Onset Diabetes Based on Serum Neurofilament Light Chain, Fibroblast Growth Factor‐19 and Standard Anthropometric and Clinical Variables
Authors: Maalmi Haifa , Nguyen Phong B. H. , Strom Alexander , Bönhof Gidon J. , Rathmann Wolfgang , Ziegler Dan , Menden Michael P. , Roden Michael , Herder Christian ,   GDS Group
Published: November 2024

ABSTRACTBackgroundDiabetic sensorimotor polyneuropathy (DSPN) is often asymptomatic and remains undiagnosed. The ability of clinical and anthropometric variables to identify individuals likely to have DSPN might be limited. Here, we aimed to integrate protein biomarkers for reliably predicting present DSPN.MethodsUsing the proximity extension assay, we measured 135 neurological and protein biomarkers of inflammation in blood samples of 423 individuals with recent‐onset diabetes from the German Diabetes Study (GDS). DSPN was diagnosed based on the Toronto Consensus Criteria. We constructed (i) a protein‐based prediction model using LASSO logistic regression, (ii) an optimised traditional risk model with age, sex, waist circumference, height and diabetes type and (iii) a model combining both. All models were bootstrapped to assess the robustness, and optimism‐corrected AUCs (95% CI) were reported.ResultsDSPN was present in 16% of the study population. LASSO logistic regression selected the neurofilament light chain (NFL) and fibroblast growth factor‐19 (FGF‐19) as the most predictive protein biomarkers for detecting DSPN in individuals with recent‐onset diabetes. The protein‐based model achieved an AUC of 0.66 (0.59, 0.73), while the traditional risk model had an AUC of 0.66 (0.61, 0.74). However, combined features boosted the model performance to an AUC of 0.72 (0.67, 0.79).ConclusionWe developed a prediction model for DSPN in recent‐onset diabetes based on two protein biomarkers and five standard anthropometric, demographic and clinical variables. The model has a fair discrimination performance and might be used to inform the referral of patients for further testing.
Dyadic Psychopathology and Adjustment to Parenthood in Families With and Without Eating Disorder History—Findings From a Longitudinal Study
Authors: Throm Jana Katharina , Dörsam Annica Franziska , Micali Nadia , Preissl Hubert , Giel Katrin Elisabeth 
Published: November 2024

ABSTRACTObjectiveTransition to parenthood is a vulnerable period for individual health and partnership quality. This study investigated parental health and partnership after childbirth in families with and without maternal eating disorder (ED) history. We report longitudinal data on parental ED psychopathology, depressive symptoms, and adjustment, including dyadic associations.MethodData derived from the prospective multi‐method cohort study EMKIE. Women with (n = 24) and without (n = 33) ED history and their partners took part from late pregnancy to 10 months postpartum and completed the Eating Disorder Examination Questionnaire, the Patient Health Questionnaire, and the Maternal Adjustment and Maternal Attitudes Questionnaire or the paternal equivalent.ResultsED psychopathology increased in mothers in both groups. Mothers in the ED group had more severe ED psychopathology, higher depression scores, and lower levels of adjustment to motherhood compared to the control group across all measurement points. No group differences emerged between partners, but ED psychopathology increased in partners of women with ED history over time. A negative correlation between maternal ED severity and paternal adjustment was observed in the ED group.DiscussionAfter childbirth, mothers with ED history experienced mental health deterioration and adjustment difficulties and fathers struggled with paternal adjustment if their partner was affected by severe ED symptoms. These results emphasize the need for close monitoring and consistent care of women with ED during this vulnerable period and highlight adjustment needs of partners of severely affected women. Further qualitative approaches are needed to deepen the knowledge of paternal experiences during this period.
Network pharmacology and molecular docking study on the potential mechanism of Tongqiao–Biyan granule in treatment of allergic rhinitis
Authors: Song Zheying , Yang Yujuan , Zhai Zhaoxue , Zhang Yu , Song Xicheng 
Published: November 2024

AbstractPurposeAllergic rhinitis (AR) is a pervasive global health problem, imposing a major economic burden and causing disability worldwide. Tongqiao–Biyan granule (TBG) has gained popularity in China for the treatment of AR. This study aimed to elucidate the molecular mechanism underlying TBG's efficacy in treating AR.MethodsThe Traditional Chinese Medicine pharmacological database was utilized to identify the main ingredients in TBG and their corresponding target genes. AR‐related target genes were identified using the GeneCards, OMIM, and DrugBank databases. The Gene Ontology (GO) network, Kyoto Encyclopedia of Genes and Genomes (KEGG), and target protein–protein interaction (PPI) network were employed to analyze the molecular mechanisms. The top five hub genes were selected for molecular docking with the top five ranked compounds to confirm their interaction in TBG when used in the treatment of AR.ResultsA total of 7 active ingredients from TBG, 784 predicted targets of TBG, and 945 AR targets were obtained. Analysis via the GO and KEGG databases revealed that TBG can act on AR by modulating inflammatory responses and promoting cell migration. PPI network analysis and molecular docking results suggested that phellopterin, quercetin, luteolin, denudatin B, and cleomiscosin A in TBG may alleviate the AR symptoms by interacting with key proteins such as TNF, AKT1, STAT3, VEGFA, and EGFR.ConclusionsTBG modulates numerous targets across diverse signaling pathways in the AR therapy. Our results furnish a theoretical foundation for further exploring TBG's pharmacological mechanism in AR treatment.
Epidemiology of hospitalized heart failure in France based on national data over 10 years, 2012–2022
Authors: Olié Valérie , Isnard Richard , Pousset Françoise , Grave Clémence , Blacher Jacques , Gabet Amélie 
Published: November 2024

AbstractAimsWe aim to describe the incidence of HF hospitalization in France in the post‐pandemic era, the prevalence of HF cases and patients' characteristics, management and outcomes while focusing on sex, age and socio‐economic differences and to analyse time‐trends between 2012 and 2022.Methods and resultsBased on the French health care database providing medical information for almost the whole French population, patients hospitalized for acute decompensated HF without history of HF in the 5 years were identified by the International Classification of Diseases – 10th revision (ICD‐10) codes. In 2022, the estimated prevalence of HF was 1.7% in France and has increased until the COVID‐19 pandemic and decreased thereafter. The incidence of acute HF decompensation reached 201.4 per 100 000 inhabitants and has decreased since 2012 (−1% per year). A significant increase of the HF incidence was found in men aged <45 years. Women aged <65 years were less likely to be admitted in a cardiac rehabilitation (CR) unit and had higher probability of one‐year mortality compared with men of the same age. One‐year mortality was significantly increased in patients from the most deprived area among extreme age group only (under 65 and ≥85 years). One‐year rehospitalization rates have decreased significantly, particularly in men aged <75 years. A decrease in ACE/ARBs deliveries was observed in both men and women.ConclusionsDespite the decrease in acute HF decompensation incidence and improvements in the management, the prevalence of HF remains stable in France and prognosis remains poor.