bluuebunny/crossref_metadata_2025_split huggingface dataset:
“This is Not Who We Are:” Progressive Media and Post-Race in the New Era of Overt Racism
Authors: Bell Katherine M 
Published: February 2019

Abstract
This analysis explores how a liberal mainstream news outlet—MSNBC—grapples with the overt racism of the current right-wing populist presidential administration in the United States. With a plethora of “good” conservatives and its stable of liberal pundits, the cable network has painted the president as mentally ill or declining, an incompetent purveyor of chaos. In perpetuating a mantra of “this is not who we are” in coverage of overt racism, MSNBC pivots to a more comfortable mainstream space of post-race, an ideological stance that places racism as a fringe anomaly. The post-race pivot belies the country’s ongoing racist legacy, and potentially lulls viewers toward acceptance of official antiracisms that serve hegemonic interests. Thus, the news coverage of the current presidency plays a role in forestalling a meaningful reckoning with the country’s ongoing history of institutional and everyday racism.
Spatial Patterns of Brain Activity Preferentially Reflecting Transient Pain and Stimulus Intensity
Authors: Liang M , Su Q , Mouraux A , Iannetti G D 
Published: February 2019

AbstractHow pain emerges in the human brain remains an unresolved question. Neuroimaging studies have suggested that several brain areas subserve pain perception because their activation correlates with perceived pain intensity. However, painful stimuli are often intense and highly salient; therefore, using both intensity- and saliency-matched control stimuli is crucial to isolate pain-selective brain responses. Here, we used these intensity/saliency-matched painful and non-painful stimuli to test whether pain-selective information can be isolated in the functional magnetic resonance imaging responses elicited by painful stimuli. Using two independent datasets, multivariate pattern analysis was able to isolate features distinguishing the responses triggered by (1) intensity/saliency-matched painful versus non-painful stimuli, and (2) high versus low-intensity/saliency stimuli regardless of whether they elicit pain. This indicates that neural activity in the so-called “pain matrix” is functionally heterogeneous, and part of it carries information related to both painfulness and intensity/saliency. The response features distinguishing these aspects are spatially distributed and cannot be ascribed to specific brain structures.
Foxg1 Antagonizes Neocortical Stem Cell Progression to Astrogenesis
Authors: Falcone Carmen , Santo Manuela , Liuzzi Gabriele , Cannizzaro Noemi , Grudina Clara , Valencic Erica , Peruzzotti-Jametti Luca , Pluchino Stefano , Mallamaci Antonello 
Published: February 2019

AbstractNeocortical astrogenesis follows neuronogenesis and precedes oligogenesis. Among key factors dictating its temporal articulation, there are progression rates of pallial stem cells (SCs) towards astroglial lineages as well as activation rates of astrocyte differentiation programs in response to extrinsic gliogenic cues. In this study, we showed that high Foxg1 SC expression antagonizes astrocyte generation, while stimulating SC self-renewal and committing SCs to neuronogenesis. We found that mechanisms underlying this activity are mainly cell autonomous and highly pleiotropic. They include a concerted downregulation of 4 key effectors channeling neural SCs to astroglial fates, as well as defective activation of core molecular machineries implementing astroglial differentiation programs. Next, we found that SC Foxg1 levels specifically decline during the neuronogenic-to-gliogenic transition, pointing to a pivotal Foxg1 role in temporal modulation of astrogenesis. Finally, we showed that Foxg1 inhibits astrogenesis from human neocortical precursors, suggesting that this is an evolutionarily ancient trait.
Foxg1 Directly Represses Dbx1 to Confine the POA and Subsequently Regulate Ventral Telencephalic Patterning
Authors: Du Ailing , Wu Xiaojing , Chen Hanhan , Bai Qing-Ran , Han Xiao , Liu Bin , Zhang Xiaohu , Ding Zhaoying , Shen Qin , Zhao Chunjie 
Published: February 2019

AbstractDuring early development, signaling centers, such as the cortical hem and the preoptic area (POA), are critical for telencephalic patterning. However, the mechanisms underlying the maintenance of signal centers are poorly understood. Here, we report that the transcription factor Foxg1 is required to confine the POA, a resource of Sonic Hedgehog (Shh) that is pivotal for ventral telencephalic development. Cell-specific deletion of Foxg1 achieved by crossing Foxg1fl/fl with Dbx1-cre or Nestin-CreER combined with tamoxifen induction results in a dramatic expansion of the POA accompanied by the significantly increased activity of the Shh signaling pathway. Ventral pattern formation was severely impaired. Moreover, we demonstrated that Foxg1 directly represses Dbx1 to restrict the POA. Furthermore, we found that the ventral pallium was expanded, which might also contribute to the observed patterning defects. These findings will improve our understanding of the maintenance of signal centers and help to elucidate the mechanisms underlying ventral telencephalic patterning.
Premotor Cortex Provides a Substrate for the Temporal Transformation of Information During the Planning of Gait Modifications
Authors: Nakajima Toshi , Fortier-Lebel Nicolas , Drew Trevor 
Published: February 2019

Abstract
We tested the hypothesis that the premotor cortex (PMC) in the cat contributes to the planning and execution of visually guided gait modifications. We analyzed single unit activity from 136 cells localized within layer V of cytoarchitectonic areas 6iffu and that part of 4δ within the ventral bank of the cruciate sulcus while cats walked on a treadmill and stepped over an obstacle that advanced toward them. We found a rich variety of discharge patterns, ranging from limb-independent cells that discharged several steps in front of the obstacle to step-related cells that discharged either during steps over the obstacle or in the steps leading up to that step. We propose that this population of task-related cells within this region of the PMC contributes to the temporal evolution of a planning process that transforms global information of the presence of an obstacle into the precise spatio-temporal limb adjustment required to negotiate that obstacle.
The Western Sahara Cases before the Court of Justice of the European Union and International Law
Authors: Kahombo Balingene 
Published: February 2019

Abstract
This paper reviews the relevance of the Western Sahara cases brought before the Court of Justice of the European Union to international law. These cases relate to the contestations of the consistency of a number of economic agreements concluded between the European Union (EU) and the Kingdom of Morocco, as well as the EU acts that approved them, with the Treaty on the European Union (TEU) and the Treaty on the Functioning of the European Union (TFEU). The issues arising from these disputes include the legality of the Court’s jurisdiction to review the validity of a treaty which is already in force between parties and the rules of international law that the contested legal instruments have violated, perhaps entailing their invalidity under EU law. While the Court has rightly found that none of the aforementioned agreements is applicable to Western Sahara—since their territorial scope does not extend to a territory which is not subject to Moroccan sovereignty——this paper tries to answer a different question as to whether the Court’s decisions are in line with international law. It is demonstrated that though the Court’s competence to rule on the validity of EU unilateral acts is obvious, the establishment of its power to review the validity of a treaty which is in force, such as the fisheries agreement of 2006, is dubious because of the inconsistency of such power with the Vienna Convention on the Law of Treaties. In any event, the question which remains to be solved—and which was not submitted to the Court—pertains to the determination of the effects of the illegal application of the EU-Morocco agreements to Western Sahara on the rights of its people. It is concluded that such an application has violated the law of occupation and eventually international human rights law. These violations do not touch upon the validity of the contested legal instruments but relate to the question of responsibility for a wrongful act stemming from the illegal application of those agreements to occupied Western Sahara in a manner which is harmful to the interest of its people.
Implementation of the Core Elements of Antibiotic Stewardship in Nursing Homes Enrolled in the National Healthcare Safety Network
Authors: Palms Danielle L , Kabbani Sarah , Bell Jeneita M , Anttila Angela , Hicks Lauri A , Stone Nimalie D 
Published: February 2019

Abstract
In 2016, 42% of nursing homes enrolled in the National Healthcare Safety Network reported meeting all 7 of the Centers for Disease Control and Prevention’s Core Elements of Antibiotic Stewardship. Bivariate analyses suggested that implementation of all core elements differed by ownership type and amount of infection prevention staff hours.
Risk of Ectopic Pregnancy and Tubal Infertility Following Gonorrhea and Chlamydia Infections
Authors: Reekie Joanne , Donovan Basil , Guy Rebecca , Hocking Jane S , Kaldor John M , Mak Donna , Preen David , Ward James , Liu Bette ,   Chlamydia and Reproductive Health Outcome Investigators, Liu B , Preen D , Hocking J , Donovan B , Roberts C , Ward J , Mak D , Guy R , Kaldor J , Pearson S , Stewart L , Wand H , Reekie J 
Published: February 2019

AbstractGonorrhea and chlamydia are important causes of pelvic inflammatory disease. Chlamydia also causes long-term sequelae, but the role of gonorrhea is unclear. We followed 300 000 reproductive-aged women for 10 years for ectopic pregnancy and tubal infertility; our findings suggest both infections confer similar increases in risk of these outcomes.
Explaining the fame of Friedman’s Presidential Address
Authors: Forder James , Sømme Kardin 
Published: February 2019

AbstractIt is noted that although in fact it lacks the revolutionary content commonly ascribed to it, Friedman’s Presidential Address to the American Economic Association is very highly regarded as an original and formative contribution. It is argued that close attention to the literature shows that it was not initially seen as original, and only after an interval of five years did the idea of its revolutionary status retrospectively, but suddenly become widely accepted. The explanation of this change of view is considered. Four explanations are suggested: one involving terminological confusion, one involving a change in theoretical priorities, and two involving debates of the 1970s, which, although they did not in fact do so, appeared to build on Friedman’s presentation, and by this appearance gave it an undeserved stature.
Efficacy, Tolerability, and Safety of Low-Volume Bowel Preparations for Patients with Inflammatory Bowel Diseases: The French Multicentre CLEAN Study
Authors: Briot C , Faure P , Parmentier A L , Nachury M , Trang C , Viennot S , Altwegg R , Bulois P , Thomassin L , Serrero M , Ah-Soune P , Gilletta C , Plastaras L , Simon M , Dray X , Caillo L , Del Tedesco E , Abitbol V , Zallot C , Degand T , Rossi V , Bonnaud G , Colin D , Morel B , Winkfield B , Danset J B , Filippi J , Amiot A , Attar A , Levy J , Peyrin-Biroulet L , Vuitton L ,   The CLEAN Study Group, Boureille Arnaud , Blain Antoine , Gay Claire , Koch Stéphane , Ambregna Sylvain , Vaurie Fanny , François Stéphanie , Martin Bérenger , Agouzal Khadija , Boivineau Lucile , Branche Julien , Gerard Romain , Benezech Alban , Aider Belinda , Rouillon Clea , Perrod Guillaume , De Montigny Stéphanie , Aygalenq Philippe 
Published: February 2019

Abstract

Background
Standard high-volume polyethylene glycol [PEG] bowel preparations [PEG-4L] are recommended for patients with inflammatory bowel disease [IBD] undergoing colonoscopy. However, low-volume preparations [≤2 L of active volume] are often used in clinical practice. The aim of this study was to evaluate the efficacy, tolerability, and safety of the various bowel preparations for patients with IBD, including low-volume preparations.

Methods
We conducted a French prospective multicentre observational study over a period of 1 month. Patients aged 18–75 years with IBD with an indication of colonoscopy independent of the study were enrolled. The choice of the preparation was left to the investigators, as per their usual protocol. The patients’ characteristics, disease, and colonoscopy characteristics were recorded, and they were given self-reported questionnaires.

Results
Twenty-five public and private hospitals enrolled 278 patients. Among them, 46 had a disease flare and 41 had bowel stenoses. Bowel preparations for colonoscopy were as follows: 42% received PEG-2L, 29% received sodium picosulfate [Pico], 15% received PEG-4L, and 14% had other preparations. The preparation did not reach the Boston’s score efficacy outcome in the PEG-4L group in 51.2% of the patients [p = 0.0011]. The preparation intake was complete for 59.5% in the PEG-4L group, compared with 82.9% in the PEG-2L group and 93.8% in the Pico group [p &lt; 0.0001]. Tolerability, as assessed by the patients’ VAS, was significantly better for both Pico and PEG-2L compared with PEG-4L, and better for Pico compared with PEG-2L [p = 0.008; p = 0.0003]. In multivariate analyses, low-volume preparations were independent factors of efficacy and tolerability. Adverse events occurred in 4.3% of the patients.

Conclusions
Preparations with PEG-2L and Pico were equally safe, with better efficacy and tolerability outcomes compared with PEG-4L preparations. The best efficacy/tolerance/safety profile was achieved with the Pico preparation.
Thermal Tolerance and Prediction of Northern Distribution of the Crapemyrtle Bark Scale (Hemiptera: Eriococcidae)
Authors: Wang Zinan , Chen Yan , Diaz Rodrigo 
Published: February 2019

AbstractPhysiological limits of non-native species to environmental factors are critical for their establishment and spread in the adventive range. The crapemyrtle bark scale, Acanthococcus lagerstroemiae (Kuwana), is a major pest of crapemyrtles. Despite concerns on its rapid spread, there is a lack of information on potential distribution range of this scale in the United States. To understand this scale’s distribution potential, its thermal tolerance was evaluated using higher and lower thermal limits. Exposure time leading to 50 and 90% mortality (Lt50 and Lt90) at extreme low or high temperatures were measured under controlled conditions. A model was then built to fit temperature data of cold fronts from 2001 to 2016 and to calculate potential mortalities along latitudes. Isothermal lines delineated at 90% mortality were defined as the northern limits. Modeling results suggested that A. lagerstroemiae nymphs collected in summer could tolerate heat; however, they were more susceptible to cold temperatures. Laboratory assays suggested that cold tolerance of A. lagerstroemiae nymphs varied from summer to winter. For example, SCP of nymphs collected in summer was higher than those collected in fall (−21 vs. −27°C), and the exposure time leading to Lt90 at 0°C was also different, which were 8 versus 50 h comparing nymphs collected in summer versus fall. Our prediction suggested that A. lagerstroemiae is likely to be limited by cold temperatures along the 43° N latitude. Based on these results, integrated management strategies can be developed for A. lagerstroemiae within the predicted range.
Severe right ventricular dilatation after repair of Tetralogy of Fallot is associated with increased left ventricular preload and stroke volume
Authors: Gnanappa Ganesh Kumar , Celermajer David S , Zhu Danyi , Puranik Rajesh , Ayer Julian 
Published: February 2019

Abstract

Aims
Pulmonary regurgitation (PR) and right ventricular (RV) dilatation are common in repaired tetralogy of Fallot (rTOF). Left ventricular (LV) dysfunction is an important risk factor in rTOF. The effect of PR/RV dilatation on LV performance and RV-LV interactions in rTOF are incompletely understood. We examined LV responses and exercise capacity in rTOF, both before and after pulmonary valve replacement (PVR).

Methods and results
Cardiac magnetic resonance imaging scans in 126 rTOF patients (age 17.3 ± 7.6 years) were analysed, comparing subjects with indexed RV end-diastolic volume (RVEDVi) <170 mL/m2 (mild/moderate dilatation, n = 95) and RVEDVi ≥170 mL/m2 (severe dilatation, n = 31). Indexed PR volume (PRVi), RV end-systolic (RVESVi), RV end-diastolic (RVEDVi), RV stroke volume (RVSVi), net pulmonary forward flow (NPFFi), LV end-diastolic (LVEDVi), LV end-systolic (LVESVi), LV stroke volume (LVSVi), RV and LV ejection fraction (EF), and diastolic septal curvature were obtained. Peak aerobic capacity (VO2 max) was measured. In a subset (n = 30), measures were obtained pre-and-post surgical PVR. Compared to those with mild/moderate RV dilatation, patients with severe RV dilation had greater PRVi (38 ± 12 vs. 24 ± 9 mL/m2, P < 0.0001), NPFFi (53 ± 9 vs. 44 ± 11 mL/m2, P < 0.0001), LVEDVi (87 ± 14 vs. 73 ± 13 mL/m2, P < 0.0001), LVESVi (39 ± 12 vs. 30 ± 8 mL/m2, P < 0.0001), and LVSVi (48 ± 7 vs. 43  ±  8 mL/m2, P = 0.002) but lower RV ejection fraction (46 ± 8 vs. 53 ± 7%, P < 0.0001). Septal curvature and VO2 max were similar in both groups. After PVR, there was no change in LVEDVi, LVSVi, septal curvature, or VO2 max.

Conclusions
Chronic PR with severe RV dilatation is associated with increased NPFFi, LVEDVi, and LVSVi. This may potentially explain preserved exercise capacity in rTOF with severe PR and RV dilatation.
Multidisciplinary approach utilizing early, intensive physical rehabilitation to accelerate recovery from veno-venous extracorporeal membrane oxygenation
Authors: Zhu Yuanjia , Bankar Deepali , Shudo Yasuhiro , Woo Y Joseph 
Published: February 2019

Abstract
This case demonstrates the benefits of our early, intensive physical rehabilitation intervention to prevent the natural sequelae occurring from prolonged bed rest. This minimizes neuromuscular weakness and optimizes strength, endurance and cardiorespiratory function, thus accelerating recovery from a long duration of femorally cannulated veno-venous extracorporeal membrane oxygenation.
Routine intraoperative jejunostomy placement and minimally invasive oesophagectomy: an unnecessary step?†
Authors: Kroese Tiuri E , Tapias Leonidas , Olive Jacqueline K , Trager Lena E , Morse Christopher R 
Published: February 2019

AbstractOBJECTIVES:Adequate nutrition is challenging after oesophagectomy. A jejunostomy is commonly placed during oesophagectomy for nutritional support. However, some patients develop jejunostomy-related complications and the benefit over oral nutrition alone is unclear. This study aims to assess jejunostomy-related complications and the impact of intraoperative jejunostomy placement on weight loss and perioperative outcomes in patients with oesophageal cancer treated with minimally invasive Ivor Lewis oesophagectomy (MIE).METHODS:From a prospectively maintained database, patients were identified who underwent MIE with gastric reconstruction. Between 2007 and 2016, a jejunostomy was routinely placed during MIE. After 2016, a jejunostomy was not utilized. Postoperative feeding was performed according to a standardized protocol and similar for both groups. The primary outcomes were jejunostomy-related complications, relative weight loss at 3 and 6 months postoperative and perioperative outcomes, including anastomotic leak, pneumonia and length of stay, respectively.RESULTS:A total of 188 patients were included, of whom 135 patients (72%) received a jejunostomy. Ten patients (7.4%) developed jejunostomy-related complications, of whom 30% developed more than 1 complication. There was no significant difference in weight loss between groups at 3 months (P = 0.73) and 6 months postoperatively (P = 0.68) and in perioperative outcomes (P-value >0.999, P = 0.591 and P = 0.513, respectively).CONCLUSIONS:The use of a routine intraoperative jejunostomy appears to be an unnecessary step in patients undergoing MIE. Intraoperative jejunostomy placement is associated with complications without improving weight loss or perioperative outcomes. Its use should be tailored to individual patient characteristics. Early oral nutrition allows patients to maintain an adequate nutritional status.
Reduced risk of gastrointestinal bleeding associated with proton pump inhibitor therapy in patients treated with dual antiplatelet therapy after myocardial infarction
Authors: Sehested Thomas S G , Carlson Nicholas , Hansen Peter W , Gerds Thomas A , Charlot Mette G , Torp-Pedersen Christian , Køber Lars , Gislason Gunnar H , Hlatky Mark A , Fosbøl Emil L 
Published: February 2019

Abstract

Aims
Guidelines differ in their recommendations on therapy to prevent gastrointestinal bleeding for patients treated with dual antiplatelet treatment (DAPT). We sought to investigate the effectiveness of proton pump inhibitors (PPIs) to prevent upper gastrointestinal (UGI) bleeding in patients using DAPT following myocardial infarction (MI) in relation to current European Society of Cardiology guidelines recommendations.

Methods and results
We linked Danish nationwide registries to identify patients taking DAPT 7 days following hospital discharge for an acute MI, and excluded individuals on anticoagulation therapy. We used multiple Cox regression modelling, to compute average risk of UGI bleeding in relation to PPI use. The associated treatment efficacy was compared based on guideline risk assessment. We studied 46 301 patients on DAPT after MI. Only 35% of patients at higher risk of UGI bleeding received recommended treatment with a PPI based on the guideline criteria. The 1--year risk of UGI bleeding was 1.0% [95% confidence interval (CI) 0.9–1.1%] and 1.7% (CI 1.5–2.0%) for high-risk patients. Overall PPI compared with no therapy, was associated with a risk ratio for UGI bleeding of 0.62 (CI 0.48–0.77) corresponding to an absolute risk difference of 0.44% (CI 0.39–0.48%). Proton pump inhibitor therapy was associated with a similar absolute risk difference [0.47% (CI 0.43–0.51%)] for high-risk patients.

Conclusion
Proton pump inhibitor therapy is used less than suggested by guidelines in patients treated with DAPT following MI and was generally associated with reduced risk of UGI bleeding. Considering the overall low risk of bleeding, more focus should be on identifying patients benefiting the most from PPI therapy.