bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the Attitudes and Knowledge of Social Work and Nursing Students on Later-Life Sexuality
Authors: Gewirtz-Meydan Ateret , Even-Zohar Ahuva , Werner Shoshi 
Published: September 2018

RÉSUMÉCette étude a examiné les croyances, les attitudes et les savoirs âgistes liés à la sexualité au grand âge chez 148 étudiants en sciences infirmières et 137 étudiants en travail social de première année. Les étudiants ont complété les questionnaires Fraboni Scale of Ageism et Attitudes and Knowledge towards Older Adult’s Sexuality Scale, ainsi que des questionnaires portant sur leurs contacts avec des personnes âgées, leur éducation sexuelle et des variables sociodémographiques. Les résultats ont montré que les étudiants en sciences infirmières avaient des attitudes plus conservatrices envers la sexualité des personnes âgées. Les croyances âgistes corrélaient positivement avec des attitudes plus conservatrices envers la sexualité des personnes âgées. Les attitudes conservatrices envers la sexualité des personnes âgées étaient négativement corrélées avec les connaissances liées à la sexualité au grand âge. Les étudiants plus âgés avaient davantage de connaissances sur la sexualité des personnes âgées et des attitudes plus permissives concernant cet aspect de la sexualité. Les étudiants plus religieux avaient moins de connaissances liées à la sexualité des personnes âgées et des attitudes plus conservatrices sur ce sujet. L’éducation sexuelle reçue par les étudiants n’était pas associée avec leurs attitudes et leurs connaissances liées à la sexualité des personnes âgées. Les implications de ces résultats pour l’élaboration de programmes d’éducation continue sont discutées.
Neurophilosophical and Ethical Aspects of Virtual Reality Therapy in Neurology and Psychiatry
Authors: KELLMEYER PHILIPP 
Published: September 2018

Abstract:Highly immersive virtual reality (VR) systems have been introduced into the consumer market in recent years. The improved technological capabilities of these systems as well as the combination with biometric sensors, for example electroencephalography (EEG), in a closed-loop hybrid VR-EEG, opens up a range of new potential medical applications. This article first provides an overview of the past and current clinical applications of VR systems in neurology and psychiatry and introduces core concepts in neurophilosophy and VR research (such as agency, trust, presence, and others). Then, important adverse effects of highly immersive VR simulations and the ethical implications of standalone and hybrid VR systems for therapy in neurology and psychiatry are highlighted. These new forms of VR-based therapy may strengthen patients in exercising their autonomy. At the same time, however, these emerging systems present ethical challenges, for example in terms of moral and legal accountability in interactions involving “intelligent” hybrid VR systems. A user-centered approach that is informed by the target patients’ needs and capabilities could help to build beneficial systems for VR therapy.
Concussion in Sport: The Unheeded Evidence
Authors: GILLETT GRANT 
Published: September 2018

Abstract:Patients with repeated minor head injury are a challenge to our clinical skills of neurodiagnosis because the relevant evidence objectively demonstrating their impairment was collected in New Zealand (although published in theBMJandLancet) and, at the time, was mired in controversy. The effects of repeated closed diffuse head injury are increasingly recognized worldwide, but now suffer from the relentless advance of imaging technology as the dominant form of neurodiagnosis and the considerable financial interests that underpin the refusal to recognize that acute accelerational injury is the most subtle and insidiously damaging (especially when seen in the light of biopsychosocial medicine), and potentially one of the most financially momentous (given the large incomes impacted and needing compensation) phenomena in modern sports medicine. The vested interests in downplaying this phenomenon are considerable and concentrated in North America where diffuse head injury is a widespread feature of the dominant winter sports code: Gridiron or American Rules football. The relationship of this to shattered lives among the brightest and best of young men and the relatively dated objective evidence are a toxic mix in terms of ethical analysis and, therefore, there is a malignant confluence of social forces that tends toward minimizing the injury.
High national and sub-national coverage of iodised salt in India: evidence from the first National Iodine and Salt Intake Survey (NISI) 2014–2015
Authors: Pandav Chandrakant S , Yadav Kapil , Salve Harshal R , Kumar Rakesh , Goel Akhil D , Chakrabarty Arijit 
Published: September 2018

AbstractObjectiveThe National Iodine and Salt Intake Survey (NISI) 2014–2015 was undertaken to estimate household iodised salt coverage at national and sub-national levels in India.DesignCross-sectional survey with multistage stratified random sampling.SettingIndia was divided into six geographic zones (South, West, Central, North, East and North-East) and each zone was further stratified into rural and urban areas to yield twelve distinct survey strata.SubjectsThe target respondent from each household was selected as per predefined priority; wife of the household head, followed by women of reproductive age, followed by any adult available during the visit.ResultsHouseholds (n5717) were surveyed and salt samples (n5682) were analysed. Household coverage of iodised salt (iodine≥5 ppm) was 91·7 (95 % CI 91·0, 92·7) %. Adequately iodised salt (iodine≥15 ppm) was consumed in 77·5 (95 % CI 76·4, 78·6) % of households. Significant differences in coverage were seen across six geographic regions, with North and North-East zones on the verge of achieving the universal salt iodisation target of >90 % coverage. Coverage of households with adequately iodised salt (adjusted OR; 95 % CI) was significantly less in rural households (0·55; 0·47, 0·64), lower/backward castes (0·84; 0·72, 0·98), deprived households (0·72; 0·61, 0·85) as assessed by multidimensional poverty index, households with non-diverse diet (0·73; 0·62, 0·86) and households using non-packaged salt (0·48; 0·39, 0·59) and non-refined salt (0·17; 0·15, 0·20).ConclusionsIndia is within striking reach of achieving universal salt iodisation. However, significant differentials by rural/urban, zonal and socio-economic indicators exist, warranting accelerated efforts and targeted interventions for high-risk groups.
Short food supply chains for local food: a difficult path
Authors: Rucabado-Palomar Thais , Cuéllar-Padilla Mamen 
Published: September 2018

AbstractAgri-food globalization is having a serious adverse impact on small- and medium-sized family farms in the province of Málaga (southern Spain), 43% of which have disappeared over the last 10 years. Short food supply chains (SFSCs) are emerging as a potential option for this type of farm, but as a strategy it is apparently not being implemented strongly enough over the region as a whole. The current case study sought to explore the initiatives carried out by local producers to date in implementing SFSCs throughout the province and to examine, from the standpoint of the production sector, the constraints hindering its development and the strategies currently being adopted with a view to addressing them. The analyses carried out under local producers perspective shows us that although SFSCs are interesting for family farms, in terms of prices, economic profit and social recognition, the abilities and capacities these channels require to producers, jointly with technical, flexibility and time demands, make these channels to be not that successful and attractive. Small producers interested in SFSCs must be aware of the special importance of social linkages and the need to take care of them; as well as of the need of establishing synergies and cooperation with other producers and stakeholders, in order to facilitate the tasks associated and that not every food product suit SFSCs.
On the Time Evolution of Climate Sensitivity and Future Warming
Authors: Goodwin Philip 
Published: September 2018

AbstractThe Earth's climate sensitivity to radiative forcing remains a key source of uncertainty in future warming projections. There is a growing realization in recent literature that research must go beyond an equilibrium and CO2‐only viewpoint, toward considering how climate sensitivity will evolve over time in response to anthropogenic and natural radiative forcing from multiple sources. Here the transient behavior of climate sensitivity is explored using a modified energy balance model, in which multiple climate feedbacks evolve independently over time to multiple sources of radiative forcing, combined with constraints from observations and from the Climate Model Intercomparison Project phase 5 (CMIP5). First, a large initial ensemble of 107 simulations is generated, with a distribution of climate feedback strengths from subannual to 102‐year timescales constrained by the CMIP5 ensemble, including the Planck feedback, the combined water vapor lapse rate feedback, snow and sea ice albedo feedback, fast cloud feedbacks, and the cloud response to sea surface temperature adjustment feedback. These 107 simulations are then tested against observational metrics representing decadal trends in warming, heat and carbon uptake, leaving only 4.6 × 103 history‐matched simulations consistent with both the CMIP5 ensemble and historical observations. The results reveal an annual timescale climate sensitivity of 2.1 °C (ranging from 1.6 to 2.8 °C at 95% uncertainty), rising to 2.9 °C (from 1.9 to 4.6 °C) on century timescales. These findings provide a link between lower estimates of climate sensitivity, based on the current transient state of the climate system, and higher estimates based on long‐term behavior of complex models and palaeoclimate evidence.
The Relationship Between Extratropical Cyclone Strength and Atmospheric River Intensity and Position
Authors: Zhang Zhenhai , Ralph F. Martin , Zheng Minghua 
Published: September 2018

AbstractExtratropical cyclones (ECs) and atmospheric rivers (ARs) impact precipitation over the U.S. West Coast and other analogous regions globally. This study investigates the relationship between ECs and ARs by exploring the connections between EC strength and AR intensity and position using a new AR intensity scale. While 82% of ARs are associated with an EC, only 45% of ECs have a paired AR and the distance between the AR and EC varies greatly. Roughly 20% of ARs (defined by vertically integrated water vapor transport) occur without a nearby EC. These are usually close to a subtropical/tropical moisture source and include an anticyclone. AR intensity is only moderately proportional to EC strength. Neither the location nor intensity of an AR can be simply determined by an EC. Greater EC intensification occurs with stronger ARs, suggesting that ARs enhance EC deepening by providing more water vapor for latent heat release.
The Relationship Between Cloud Radiative Effect and Surface Temperature Variability at El Niño‐Southern Oscillation Frequencies in CMIP5 Models
Authors: Lutsko Nicholas J. 
Published: September 2018

AbstractThe relationship between the tropical cloud radiative effect (CRE) and tropical surface temperature variability on El Niño–Southern Oscillation (ENSO) time scales is investigated in preindustrial control simulations from the fifth Climate Model Intercomparison Project (CMIP5) archive. The tropical CRE is binned according to midtropospheric vertical velocities and then regressed in frequency space versus tropical mean surface temperatures. Low clouds play a leading role in the relationship between clouds and surface temperature variability, amplifying ENSO‐induced surface temperature anomalies through thermodynamically driven changes in the shortwave CRE. Changes in CRE driven by changes in the large‐scale dynamics have a minor influence on surface temperature variability. It is shown that the regression coefficients at ENSO frequencies between the CRE in regions of moderate subsidence and of weak ascent, and tropical mean surface temperatures are well correlated with models' climate sensitivities, constituting a potential emergent constraint on climate sensitivity.
Viscoelastic Tides of Mercury and the Determination of its Inner Core Size
Authors: Steinbrügge G. , Padovan S. , Hussmann H. , Steinke T. , Stark A. , Oberst J. 
Published: September 2018

AbstractWe computed interior structure models of Mercury and analyzed their viscoelastic tidal response. The models are consistent with MErcury Surface, Space Environment, GEochemistry, and Ranging mission inferences of mean density, mean moment of inertia, moment of inertia of mantle and crust, and tidal Love number k2. Based on these constraints we predict the tidal Love number h2 to be in the range from 0.77 to 0.93. Using an Andrade rheology for the mantle the tidal phase‐lag is predicted to be 4° at maximum. The corresponding tidal dissipation in Mercury's silicate mantle induces a surface heat flux smaller than 0.16 mW/m2. We show that, independent of the adopted mantle rheological model, the ratio of the tidal Love numbers h2 and k2 provides a better constraint on the maximum inner core size with respect to other geodetic parameters (e.g., libration amplitude or a single Love number), provided it responds elastically to the solar tide. For inner cores larger than 700 km, and with the expected determination of h2 from the upcoming BepiColombo mission, it may be possible to constrain the size of the inner core. The measurement of the tidal phase‐lag with an accuracy better than ≈0.5° would further allow constraining the temperature at the core‐mantle boundary for a given grain size and therefore improve our understanding of the physical structure of Mercury's core.
Long‐Term Monitoring of Macroinvertebrate Communities Over 2,300 km of the Murray River Reveals Ecological Signs of Salinity Mitigation Against a Backdrop of Climate Variability
Authors: Paul Warren L. , Cook Robert A. , Suter Phillip J. , Clarke K. Robert , Shackleton Michael E. , McInerney Paul J. , Hawking John H. 
Published: September 2018

AbstractWe investigated the ecological effects of salinity mitigation strategies in the Murray‐Darling Basin (MDB) using macroinvertebrate data collected over 2,300 km of the Murray River between 1980 and 2012. The MDB covers 1 × 106km2 and includes both temperate and semiarid climate zones. It was extensively developed to support irrigated agriculture in the early to mid‐1900s, and the secondary salinization that followed has become a major concern. During 1975–1985 daily salinity levels, measured as electrical conductivity above the Murray River off‐take points for South Australia's major urban water supplies, were above 800 μS/cm for 40% of the time, necessitating mitigation strategies that have reduced the average salinity by about 150 μS/cm since monitoring began. The MDB has also experienced several major floods and droughts during this time, and surface temperatures in the MDB have increased by 0.8 °C since 1910, mostly in the last 50 years. We hypothesized that (1) taxa richness would increase in response to floods; (2) community structure would shift toward tolerant, opportunistic taxa in response to warming; and (3) geographical ranges of species would change in response to shifting stream isotherms and reducing salinity. Our hypotheses were supported, although increases in water temperature appeared to be due principally to the 1997–2009 Millennium drought. Importantly, against a backdrop of significant climate variability, we believe we have distinguished a change in community structure along a salinity gradient and that changes over the 33 years can in part be attributed to mitigation strategies.
The Value of Using Multiple Hydrometeorological Variables to Predict Temporal Debris Flow Susceptibility in an Alpine Environment
Authors: Prenner D. , Kaitna R. , Mostbauer K. , Hrachowitz M. 
Published: September 2018

AbstractDebris flows are typically triggered by rainfall‐related weather conditions—including short‐duration storms and long‐lasting rainfall, in cold climates sometimes in connection with intensive snowmelt. Given the considerable observational uncertainties of rainfall, we tested if other hydrometeorological variables carry enough information content to compensate for these uncertainties and if the combined information of hydrologic catchment state and rainfall can be used to predict the regional temporal susceptibility for debris flow initiation. For this we carried out a probabilistic analysis of variables derived from a conceptual hydrological model for the Montafon region, Austria, where debris flows were recorded on 41 days between 1953 and 2013. Exclusively from hydrological characteristics and, importantly, neglecting precipitation itself, we quantitatively determined different trigger types for historical debris flows. Subsequently, we used four Naive Bayes classifier models, ranging from a simple rainfall‐only model to a multiparameter hydrometeorological model differentiating between trigger types, to predict days susceptible for debris flow occurrence in the region. The results suggest that debris flows were triggered by convective rainstorm events on 23 days, on 12 days due to gradual soil moisture buildup in the course of long‐lasting rainfall events and on six further days snowmelt played an important role. We find that the differences between the trigger types are statistically significant and that a susceptibility prediction differentiating between trigger types and including hydrological information can outperform simple rainfall‐only models. This study thereby contributes to an improved understanding of the hydrometeorological impact on debris flow initiation in a mountain watershed.
Inside or Outside: Quantifying Extrapolation Across River Networks
Authors: Booker Douglas J. , Whitehead Amy L. 
Published: September 2018

AbstractRegression techniques are often used to predict responses across landscapes or under scenarios describing changes in climate, management, or land cover. The ability of random forests (RFs) and multivariate adaptive regression splines (MARS) to predict flow variability, low flow, Escherichia coli, and a macroinvertebrate community index was compared. Cross validation was applied to test predictive performance across an induced spectrum of interpolation to extrapolation by splitting each data set into two geographical, environmental, and random groups. RF and MARS both represent nonlinear and interacting patterns but showed contrasting ability to interpolate and extrapolate. RF always performed better than MARS when interpolating within environmental space or extrapolating in geographical space. RF models for all four responses were transferable in geographic space but not to environmental conditions outside the training data. Neither technique was successful when extrapolating across environmental gradients, although RF out‐performed MARS, despite RF predictions being constrained by the training data. New methods to quantify interpolation versus extrapolation for predictions are demonstrated. Degree of extrapolation is calculated by transforming both the training data and new predictors in response turnover space. A decline in cross‐validation performance was related to an increase in degree of extrapolation regardless of whether extrapolating in geographical or environmental space. Degree of extrapolation is valuable. It identifies those predictions that are more reliable because they represent interpolation versus those that are more uncertain that represent extrapolation. For example, high degree of extrapolation under climate or land cover change indicates increased risk of producing misleading predictions from both RF and MARS.
RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity
Authors: Fang Hongbo , Niu Kaifeng , Mo Dongliang , Zhu Yuqi , Tan Qunsong , Wei Di , Li Yueyang , Chen Zixiang , Yang Shuchen , Balajee Adayabalam S. , Zhao Yongliang 
Published: September 2018

AbstractHuman RecQL4 helicase plays critical roles in the maintenance of genomic stability. Mutations in RecQL4 helicase results in three clinically related autosomal recessive disorders: Rothmund–Thomson syndrome (RTS), RAPADILINO, and Baller–Gerold syndrome. In addition to several premature aging features, RTS patients are characterized by aneuploidy involving either loss or gain of a single chromosome. Chromosome mosaicism and isochromosomes involving chromosomes 2, 7, and 8 have been reported in RecQL4-deficient RTS patients, but the precise role of RecQL4 in chromosome segregation/stability remains to be elucidated. Here, we demonstrate that RecQL4 physically and functionally interacts with Aurora B kinase (AURKB) and stabilizes its expression by inhibiting its ubiquitination process. Our study indicates that the N-terminus of RecQL4 interacts with the catalytic domain of AURKB. Strikingly, RecQL4 suppression reduces the expression of AURKB leading to mitotic irregularities and apoptotic cell death. RecQL4 suppression increases the proportion of cells at the G2/M phase followed by an extensive cell death, presumably owing to the accumulation of mitotic irregularities. Both these defects (accumulation of cells at G2/M phase and an improper mitotic exit to sub-G1) are complemented by the ectopic expression of AURKB. Finally, evidence is provided for the requirement of both human telomerase reverse transcriptase and RecQL4 for stable immortalization and longevity of RTS fibroblasts. Collectively, our study suggests that the RecQL4–AURKB axis is essential for cellular proliferation, cell cycle progression, and mitotic stability in human cells.
Association of schizophrenia polygenic risk score with manic and depressive psychosis in bipolar disorder
Authors: Markota Matej , Coombes Brandon J. , Larrabee Beth R. , McElroy Susan L. , Bond David J. , Veldic Marin , Colby Colin L. , Chauhan Mohit , Cuellar-Barboza Alfredo B. , Fuentes Manuel , Kung Simon , Prieto Miguel L. , Rummans Teresa A. , Bobo William V. , Frye Mark A. , Biernacka Joanna M. 
Published: September 2018

AbstractBipolar disorder (BD) is highly heterogeneous in symptomatology. Narrowing the clinical phenotype may increase the power to identify risk genes that contribute to particular BD subtypes. This study was designed to test the hypothesis that genetic overlap between schizophrenia (SZ) and BD is higher for BD with a history of manic psychosis. Analyses were conducted using a Mayo Clinic Bipolar Biobank cohort of 957 bipolar cases (including 333 with history of psychosis during mania, 64 with history of psychosis only during depression, 547 with no history of psychosis, and 13 with unknown history of psychosis) and 778 controls. Polygenic risk score (PRS) analysis was performed by calculating a SZ-PRS for the BD cases and controls, and comparing the calculated SZ risk between different psychosis subgroups and bipolar types. The SZ-PRS was significantly higher for BD-I cases with manic psychosis than BD-I cases with depressive psychosis (Nagelkerke’s R2 = 0.021; p = 0.045), BD-I cases without psychosis (R2 = 0.015; p = 0.007), BD-II cases without psychosis (R2 = 0.014; p = 0.017), and controls (R2 = 0.065; p = 2 × 10−13). No other significant differences were found. Our results show that BD-I with manic psychosis is genetically more similar to SZ than any other tested BD subgroup. Further investigations on genetics of distinct clinical phenotypes composing major psychoses may help refine the current diagnostic classification system.