bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review on window-glazing technologies and future prospects
Authors: Aguilar-Santana Jorge Luis , Jarimi Hasila , Velasco-Carrasco Mariana , Riffat Saffa 
Published: May 2019

Abstract
Windows are one of the significant indicators of the energy efficiency of a building and have undergone extensive research since the last decades. This paper reviews the performance of various window technologies covering the physical and optical properties of traditional windows and advanced window technologies. In window technologies, one of the most critical parameters is its thermal transmittance value or also known as U-value. In this paper, we discuss the relationship between the physical and optical parameters of the different types of windows and its U-value. Additionally, this paper will also provide interested readers with a wide range of information, including the research gaps in window technologies. Among the main conclusions, we found that, although several advancements have been achieved in this field in the last decade, further research is needed to develop window technologies that not only have high insulating properties but also can generate power.
Pure Viral Sepsis Secondary to Community-Acquired Pneumonia in Adults: Risk and Prognostic Factors
Authors: Cillóniz Catia , Dominedò Cristina , Magdaleno Daniel , Ferrer Miquel , Gabarrús Albert , Torres Antoni 
Published: May 2019

AbstractWe investigated the risk and prognostic factors of pure viral sepsis in adult patients with community-acquired pneumonia (CAP), using the Sepsis-3 definition. Pure viral sepsis was found in 3% of all patients (138 of 4028) admitted to the emergency department with a diagnosis of CAP, 19% of those with CAP (138 of 722) admitted to the intensive care unit, and 61% of those (138 of 225) with a diagnosis of viral CAP. Our data indicate that males and patients aged ≥65 years are at increased risk of viral sepsis.
Once-Weekly Oral Dosing of MK-8591 Protects Male Rhesus Macaques From Intrarectal Challenge With SHIV109CP3
Authors: Markowitz Martin , Gettie Agegnehu , St. Bernard Leslie , Andrews Chasity D , Mohri Hiroshi , Horowitz Amir , Grasperge Brooke F , Blanchard James L , Niu Tao , Sun Li , Fillgrove Kerry , Hazuda Daria J , Grobler Jay A 
Published: May 2019

Abstract

Background
MK-8591 (4′-ethynyl-2-fluoro-2′-deoxyadenosine [EFdA]) is a novel reverse transcriptase–translocation inhibitor.

Methods
We assessed MK-8591 as preexposure prophylaxis in the rhesus macaque model of intrarectal challenge with simian/human immunodeficiency virus (SHIV). In study 1, 8 rhesus macaques received 3.9 mg/kg of MK-8591 orally on day 0 and once weekly for the next 14 weeks. Eight controls were treated with vehicle. All rhesus macaques were challenged with SHIV109CP3 on day 6 and weekly for up to 12 challenges or until infection was confirmed. The dose of MK-8591 was reduced to 1.3 and 0.43 mg/kg/week in study 2 and further to 0.1 and 0.025 mg/kg/week in study 3. In studies 2 and 3, each dose was given up to 6 times once weekly, and animals were challenged 4 times once weekly with SHIV109CP3.

Results
Control macaques were infected after a median of 1 challenge (range, 1–4 challenges). All treated animals in studies 1 and 2 were protected, consistent with a 41.5-fold lower risk of infection (P &lt; .0001, by the log-rank test). In study 3, at a 0.1-mg/kg dose, 2 rhesus macaques became infected, consistent with a 7.2-fold lower risk of infection (P = .0003, by the log-rank test). The 0.025-mg/kg dose offered no protection.

Conclusions
These data support MK-8591’s potential as a preexposure prophylaxis agent.
Medication safety alert fatigue may be reduced via interaction design and clinical role tailoring: a systematic review
Authors: Hussain Mustafa I , Reynolds Tera L , Zheng Kai 
Published: May 2019

AbstractObjectiveAlert fatigue limits the effectiveness of medication safety alerts, a type of computerized clinical decision support (CDS). Researchers have suggested alternative interactive designs, as well as tailoring alerts to clinical roles. As examples, alerts may be tiered to convey risk, and certain alerts may be sent to pharmacists. We aimed to evaluate which variants elicit less alert fatigue.Materials and MethodsWe searched for articles published between 2007 and 2017 using the PubMed, Embase, CINAHL, and Cochrane databases. We included articles documenting peer-reviewed empirical research that described the interactive design of a CDS system, to which clinical role it was presented, and how often prescribers accepted the resultant advice. Next, we compared the acceptance rates of conventional CDS—presenting prescribers with interruptive modal dialogs (ie, “pop-ups”)—with alternative designs, such as role-tailored alerts.ResultsOf 1011 articles returned by the search, we included 39. We found different methods for measuring acceptance rates; these produced incomparable results. The most common type of CDS—in which modals interrupted prescribers—was accepted the least often. Tiering by risk, providing shortcuts for common corrections, requiring a reason to override, and tailoring CDS to match the roles of pharmacists and prescribers were the most common alternatives. Only 1 alternative appeared to increase prescriber acceptance: role tailoring. Possible reasons include the importance of etiquette in delivering advice, the cognitive benefits of delegation, and the difficulties of computing “relevance.”ConclusionsAlert fatigue may be mitigated by redesigning the interactive behavior of CDS and tailoring CDS to clinical roles. Further research is needed to develop alternative designs, and to standardize measurement methods to enable meta-analyses.
Reconstruction of Deep Burn Wounds Around the Ankle With Free Fascia Flaps Transfer and Split-Thickness Skin Graft
Authors: Yang Xuekang , Fang Zhuoqun , Liu Mengdong , Zhang Yue , Chen Qiaohua , Tao Ke , Han Juntao , Hu Dahai 
Published: May 2019

Abstract
We aimed to introduce a technique by combining free fascia flaps transfer with split-thickness skin graft for the reconstruction of deep burn wounds at the ankle. Fifteen patients from 2009 to 2016 were enrolled in this study. Patients in this series suffered from a deep burn injury around the ankle, which was accompanied with exposure of tendon and medial or lateral malleolus exposure due to severe soft-tissue defects (N = 15). All the 15 wounds were repaired combining free fascia flaps with split-thickness skin graft operations, including nine anterolateral thigh fascia lata flaps (ATFL flaps) and six superficial temporal fascia flaps (STF flaps). All the fascia flaps completely survived. Two patients showed partial grafting skin necrosis due to either wound infection or subcutaneous hematoma infection, and this was eventually healed satisfactorily after conventional dressing change. All patients achieved esthetic outcome and acceptable functionality without further revisions needed. Our present study reports a useful method that involves using free fascia flaps in combination with split-thickness skin graft to repair deep burn wounds around the ankle. This method provided reliable and durable soft-tissue coverage with good outcomes.
Comparative analysis of the mine pressure at non-pillar longwall mining by roof cutting and traditional longwall mining
Authors: Zhou Peng , Wang Yajun , Zhu Guolong , Gao Yubing 
Published: May 2019

Abstract
Non-pillar coal mining has been developed and implemented in the recent decades in China's coal mining industry. The non-pillar longwall mining by roof cutting without pre-excavated entry (N00 mining method) is one of the latest non-pillar mining methods and this method has the advantages of reduced roadway drivage ratio and increased resource recovery ratio. Previous studies show that the mining pressure during the working face advancing is one of the main factors that affect the stability of underground structures and the safety production. However, there is no evaluation or analysis of the mining pressure at the mining face using entry retaining with roof pre-cutting and an absence of pre-excavated tail entry. In this paper, both field monitoring and numerical simulation approaches are employed in the analysis of the mining pressure distribution characteristics within a range of the whole working face during the face advancing. The results are compared with the field data and simulation results from the traditional mining method performed in the same coal mine. Results supported the idea that the N00 mining method can generate a low-stress area for the retained entry. The stability of the working face and retained entry can be well maintained due to the mine pressure optimization. This paper can aid in the understanding of structural mechanic modeling and mine pressure distribution features, structural mechanic analysis and mine pressure distribution features of the N00 mining method.
Assessing Children’s Eudaimonic Well-Being: The PROMIS Pediatric Meaning and Purpose Item Banks
Authors: Forrest Christopher B , Bevans Katherine B , Filus Ania , Devine Janine , Becker Brandon D , Carle Adam C , Teneralli Rachel E , Moon JeanHee , Ravens-Sieberer Ulrike 
Published: May 2019

Abstract

Objective
To describe the development of the Patient-Reported Outcome Measurement Information System (PROMIS) Pediatric Meaning and Purpose item banks, child-report and parent-proxy editions.

Methods
Data were collected from two samples. The first comprised 1,895 children (8–17 years old) and 927 parents of children 5–17 years old recruited from an Internet panel, medical clinics, and schools. The second comprised a nationally representative sample of 990 children 8–17 years old and 1,292 parents of children 5–17 years old recruited from a different Internet panel. Item pool evaluation was done with Sample 1 and analyses were used to support decisions about item retention. The combined sample was used for item response theory (IRT) calibration of the item bank. Both samples were used in validation studies.

Results
Eleven items were deleted from the item pool because of poor psychometric performance. The final versions of the scales showed excellent reliability (>0.90). Short form scales (4 or 8 items) had a high degree of precision across over 4 SD units of the latent variable. The item bank positively correlated with extant measures of positive psychological functioning, and negatively correlated with measures of emotional distress, pessimism, and pain. Lower meaning and purpose scores were associated with adolescence and presence of a special healthcare need.

Conclusion
The PROMIS Pediatric Meaning and Purpose item banks and their short forms are ready for use in clinical research and practice. They are measures of children’s eudaimonic well-being and indicative of children’s hopefulness, optimism, goal-directedness, and feelings that life is worth living.
Impact of delivery characteristics on dose delivery accuracy of volumetric modulated arc therapy for different treatment sites
Authors: Li Jiaqi , Zhang Xile , Li Jun , Jiang Rongtao , Sui Jing , Chan Maria F , Yang Ruijie 
Published: May 2019

Abstract
This study aimed to investigate the impact of delivery characteristics on the dose delivery accuracy of volumetric modulated arc therapy (VMAT) for different treatment sites. The pretreatment quality assurance (QA) results of 344 VMAT patients diagnosed with gynecological (GYN), head and neck (H&N), rectal or prostate cancer were randomly chosen in this study. Ten metrics reflecting VMAT delivery characteristics were extracted from the QA plans. Compared with GYN and rectal plans, H&N and prostate plans had higher aperture complexity and monitor units (MU), and smaller aperture area. Prostate plans had the smallest aperture area and lowest leaf speed compared with other plans (P < 0.001). No differences in gantry speed were found among the four sites. The gamma passing rates (GPRs) of GYN, rectal and H&N plans were inversely associated with union aperture area (UAA) and leaf speed (Pearson’s r: −0.39 to −0.68). GPRs of prostate plans were inversely correlated with aperture complexity, MU and small aperture score (SAS) (absolute Pearson’s r: 0.34 to 0.49). Significant differences in GPR between high SAS and low SAS subgroups were found only when leaf speed was <0.42 cm s–1 (P < 0.001). No association of GPR with gantry speed was found in four sites. Leaf speed was more strongly associated with UAA. Aperture complexity and MU were more strongly associated with SAS. VMAT plans from different sites have distinct delivery characteristics. Affecting dose delivery accuracy, leaf speed is the key factor for GYN, rectal and H&N plans, while aperture complexity, MU and small apertures have a higher influence on prostate plans.
Proton therapy for non-squamous cell carcinoma of the head and neck: planning comparison and toxicity
Authors: Iwata Hiromitsu , Toshito Toshiyuki , Hayashi Kensuke , Yamada Maho , Omachi Chihiro , Nakajima Koichiro , Hattori Yukiko , Hashimoto Shingo , Kuroda Yo , Okumura Yoshihide , Mizoe Jun-etsu , Ogino Hiroyuki , Shibamoto Yuta 
Published: May 2019

AbstractTo investigate optimal treatment planning using proton beams for non-squamous cell carcinoma of the head and neck (NSCHN), the dose distributions of plans involving pencil beam scanning (PBS) with or without a patient-specific aperture system (PSAS), passive-scattering proton therapy (PSPT) and X-ray intensity-modulated radiotherapy (IMRT) were compared. As clinical results, toxicities of PBS with PSAS, including changes in quality of life, were reported. Between April 2014 and August 2016, a total of 30 patients were treated using PBS with PSAS. In 20 patients selected at random, the dose distributions of PBS with or without the PSAS, PSPT and IMRT plans were compared. Neutron exposure by proton therapy was calculated using a Monte Carlo simulation. Toxicities were scored according to CTCAE ver. 4.0. Patients completed EORTC quality of life survey forms (QLQ-C30 and QLQ-HN35) before and 0–12 months after proton therapy. The 95% conformity number of PBS with the PSAS plan was the best, and significant differences were detected among the four plans (P < 0.05, Bonferroni tests). Neutron generation by PSAS was ~1.1-fold higher, but was within an acceptable level. No grade 3 or higher acute dermatitis was observed. Pain, appetite loss and increased weight loss were more likely at the end of treatment, but recovered by the 3 month follow-up and returned to the pretreatment level at the 12 month follow-up. PBS with PSAS reduced the penumbra and improved dose conformity in the planning target volume. PBS with PSAS was tolerated well for NSCHN.
Application of laser capture microdissection and polymerase chain reaction in the diagnosis of Trichoderma longibrachiatum infection: a promising diagnostic tool for ‘fungal contaminants’ infection
Authors: Zhou Ya Bin , Zhang Gong Jie , Song Ying Gai , Sun Li Na , Chen Ya Hong , Sun Ting Ting , Li Ruo Yu , Liu Wei , Li Dong Ming 
Published: May 2019

Abstract
Although Trichoderma species are usually considered to be culture contaminants, an increasing number of case reports have demonstrated their pathogenicity. Current diagnostic tools, including fungal culture, radiology, histopathology, and direct microscopy examination, are often unable to differentiate the pathogenicity of ‘fungal contaminants’ such as Trichoderma species in patients. Accurate diagnostic tools for ‘fungal contaminants’ infection have become the urgent needs. To that end, we applicated laser capture microdissection (LCM) and polymerase chain reaction (PCR) to confirm T. longibrachiatum infection for the first time. A 57-year-old man presented with a cough and hemoptysis lasting for more than 40 days. Computed tomography scan revealed a mass at the left hilum. In addition to pulmonary spindle cell carcinoma, fungal hyphae were also detected in histopathological examination. The cultured fungus was identified as T. longibrachiatum using molecular procedures. The results from DNA sequencing of DNA obtained by LCM revealed the identical result. Antifungal susceptibility testing revealed resistance to itraconazole, fluconazole and flucytosine. The patient was managed with oral voriconazole for 4 months. No relapse of Trichoderma infection was observed at a year follow-up visit. Although there are potential disadvantages, LCM-based molecular biology technology is a promising diagnostic tool for ‘fungal contaminants’ infection.
False negative diagnostic errors with polymerase chain reaction for the detection of cryptococcal meningoencephalitis
Authors: Lewis Paul O , Lanier Cameron G , Patel Paras D , Krolikowski Whitney D , Krolikowski Matthew A 
Published: May 2019

Abstract
The accuracy of the BioFire FilmArray Meningitis/Encephalitis (ME) panel for the identification of Cryptococcus has recently been called into question. The primary objective of this study was to assess the agreement between the BioFire ME polymerase chain reaction (PCR) and other markers of cryptococcal infection. This retrospective review identified five patients with cryptococcal meningoencephalitis, 4 of whom had a negative ME panel for Cryptococcus. All five cases had positive serum cryptococcal antigens, and three of five had a positive cerebrospinal fluid (CSF) culture for Cryptococcus. The BioFire ME panel does not appear to be reliable for ruling out Cryptococcus meningoencephalitis; multiple testing methods are recommended.
Superluminous supernovae from the Dark Energy Survey
Authors: Angus C R , Smith M , Sullivan M , Inserra C , Wiseman P , D’Andrea C B , Thomas B P , Nichol R C , Galbany L , Childress M , Asorey J , Brown P J , Casas R , Castander F J , Curtin C , Frohmaier C , Glazebrook K , Gruen D , Gutierrez C , Kessler R , Kim A G , Lidman C , Macaulay E , Nugent P , Pursiainen M , Sako M , Soares-Santos M , Thomas R C , Abbott T M C , Avila S , Bertin E , Brooks D , Buckley-Geer E , Burke D L , Carnero Rosell A , Carretero J , da Costa L N , De Vicente J , Desai S , Diehl H T , Doel P , Eifler T F , Flaugher B , Fosalba P , Frieman J , García-Bellido J , Gruendl R A , Gschwend J , Hartley W G , Hollowood D L , Honscheid K , Hoyle B , James D J , Kuehn K , Kuropatkin N , Lahav O , Lima M , Maia M A G , March M , Marshall J L , Menanteau F , Miller C J , Miquel R , Ogando R L C , Plazas A A , Romer A K , Sanchez E , Schindler R , Schubnell M , Sobreira F , Suchyta E , Swanson M E C , Tarle G , Thomas D , Tucker D L ,   (DES Collaboration)
Published: May 2019

ABSTRACT
We present a sample of 21 hydrogen-free superluminous supernovae (SLSNe-I) and one hydrogen-rich SLSN (SLSN-II) detected during the five-year Dark Energy Survey (DES). These SNe, located in the redshift range 0.220 &lt; z &lt; 1.998, represent the largest homogeneously selected sample of SLSN events at high redshift. We present the observed g, r, i, z light curves for these SNe, which we interpolate using Gaussian processes. The resulting light curves are analysed to determine the luminosity function of SLSNe-I, and their evolutionary time-scales. The DES SLSN-I sample significantly broadens the distribution of SLSN-I light-curve properties when combined with existing samples from the literature. We fit a magnetar model to our SLSNe, and find that this model alone is unable to replicate the behaviour of many of the bolometric light curves. We search the DES SLSN-I light curves for the presence of initial peaks prior to the main light-curve peak. Using a shock breakout model, our Monte Carlo search finds that 3 of our 14 events with pre-max data display such initial peaks. However, 10 events show no evidence for such peaks, in some cases down to an absolute magnitude of &lt;−16, suggesting that such features are not ubiquitous to all SLSN-I events. We also identify a red pre-peak feature within the light curve of one SLSN, which is comparable to that observed within SN2018bsz.
The GALAH survey: unresolved triple Sun-like stars discovered by the Gaia mission
Authors: Čotar Klemen , Zwitter Tomaž , Traven Gregor , Kos Janez , Asplund Martin , Bland-Hawthorn Joss , Buder Sven , D’Orazi Valentina , De Silva Gayandhi M , Lin Jane , Martell Sarah L , Sharma Sanjib , Simpson Jeffrey D , Zucker Daniel B , Horner Jonathan , Lewis Geraint F , Nordlander Thomas , Ting Yuan-Sen , Wittenmyer Rob A , GALAH collaboration  
Published: May 2019

Abstract
The latest Gaia data release enables us to accurately identify stars that are more luminous than would be expected on the basis of their spectral type and distance. During an investigation of the 329 best solar twin candidates uncovered among the spectra acquired by the GALAH survey, we identified 64 such overluminous stars. In order to investigate their exact composition, we developed a data-driven methodology that can generate a synthetic photometric signature and spectrum of a single star. By combining multiple such synthetic stars into an unresolved binary or triple system and comparing the results to the actual photometric and spectroscopic observations, we uncovered 6 definitive triple stellar system candidates and an additional 14 potential candidates whose combined spectrum mimics the solar spectrum. Considering the volume correction factor for a magnitude-limited survey, the fraction of probable unresolved triple stars with long orbital periods is ∼2 per cent. Possible orbital configurations of the candidates were investigated using the selection and observational limits. To validate the discovered multiplicity fraction, the same procedure was used to evaluate the multiplicity fraction of other stellar types.
mCSM-PPI2: predicting the effects of mutations on protein–protein interactions
Authors: Rodrigues Carlos H M , Myung Yoochan , Pires Douglas E V , Ascher David B 
Published: May 2019

AbstractProtein–protein Interactions are involved in most fundamental biological processes, with disease causing mutations enriched at their interfaces. Here we present mCSM-PPI2, a novel machine learning computational tool designed to more accurately predict the effects of missense mutations on protein–protein interaction binding affinity. mCSM-PPI2 uses graph-based structural signatures to model effects of variations on the inter-residue interaction network, evolutionary information, complex network metrics and energetic terms to generate an optimised predictor. We demonstrate that our method outperforms previous methods, ranking first among 26 others on CAPRI blind tests. mCSM-PPI2 is freely available as a user friendly webserver at http://biosig.unimelb.edu.au/mcsm_ppi2/.
Simple ClinVar: an interactive web server to explore and retrieve gene and disease variants aggregated in ClinVar database
Authors: Pérez-Palma Eduardo , Gramm Marie , Nürnberg Peter , May Patrick , Lal Dennis 
Published: May 2019

Abstract
Clinical genetic testing has exponentially expanded in recent years, leading to an overwhelming amount of patient variants with high variability in pathogenicity and heterogeneous phenotypes. A large part of the variant level data is aggregated in public databases such as ClinVar. However, the ability to explore this rich resource and answer general questions such as ‘How many genes inside ClinVar are associated with a specific disease? or ‘In which part of the protein are patient variants located?’ is limited and requires advanced bioinformatics processing. Here, we present Simple ClinVar (http://simple-clinvar.broadinstitute.org/) a web server application that is able to provide variant, gene and disease level summary statistics based on the entire ClinVar database in a dynamic and user-friendly web-interface. Overall, our web application is able to interactively answer basic questions regarding genetic variation and its known relationships to disease. By typing a disease term of interest, the user can identify in seconds the genes and phenotypes most frequently reported to ClinVar. Subsets of variants can then be further explored, filtered or mapped and visualized in the corresponding protein sequences. Our website will follow ClinVar monthly releases and provide easy access to ClinVar resources to a broader audience including basic and clinical scientists.