bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the antibacterial potency of Schiff base derivatives as potential agents for urinary tract infection: DFT, solvation, molecular docking and pharmacokinetic studies
Authors: Godfrey Obinna C. , Edo Godwin , Nwoko Magnus C. , Gulack Alpha O. , Okon Gideon A. , Edim Moses M. 
Published: November 2024

Abstract
Owing to the growing prevalence of uropathogenic Escherichia coli (UPEC) strains that are more recently resistant to last-line antibiotic treatments, such as carbapenems and colistin drugs, urinary tract infections (UTIs) are a prime example of the antibiotic resistance crisis and emphasize the need for new approaches to treat and prevent bacterial infections. The antibacterial effect of 4-((5-bromo-2-hydroxybenzlidene) amino)-1,5-dimethyl1-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (BDP), a Schiff base derivative, was tested against UPEC, a bacterium responsible for urinary tract infections. This Schiff base compound was optimized in five phases at the ωB97XD/6–311++G(2d,2p) level of theory; therefore, density functional theory studies, spectroscopic analysis, molecular docking analysis, and pharmacokinetic prediction were employed. The stability of the BDP compound was predicted via geometric structural studies, natural bond orbital (NBO) theory, quantum chemical descriptors, and spectral studies such as FT-IR and UV‒vis studies. The ab initio calculation of NBO revealed greater stability of the compound despite the solvation effects of DMSO, methanol, ethanol, and water. This claim was supported by frontier molecular orbital prediction, where the energy gaps were 6.60 eV, 7.45 eV, 7.45 eV, 7.43 eV, and 7.44 eV for the BDP compound present in the gas phase, water, DMSO, ethanol and methanol, respectively. The molecular docking results revealed the antibacterial efficacy of BDP. 5C5Z + BDP and 5VQ5+BDP interactions produced −4.5 and −5.4 kcal/mol binding affinities respectively. BDP displayed stronger interaction with 5VQ5 than with 5C5Z and had better docking activities than FOS. Overall, result has shown that BDP is a potential therapeutic candidate for the treatment of UPEC caused UTIs and has the potential to mitigate the challenges associated with urinary tract infections, hence, should be considered a promising candidate for UTI treatment.
REPRODUCTIVE HEALTH IN TRANS AND GENDER-DIVERSE PATIENTS: Trauma-informed reproductive care for transgender and nonbinary people
Authors: Stroumsa Daphna , Raja Nicholas S , Russell Colin B 
Published: November 2024

In brief
There are some unique aspects to providing trauma-informed reproductive care to transgender and nonbinary people, who are affected by minority stress, stigma, and particular forms of trauma; we review the evidence and suggest strategies for the provision of trauma-informed reproductive care to gender minorities.

Abstract
Stigma and minority stress affect the health of transgender and nonbinary (TGNB) people, leading to disparities across a range of outcomes. Barriers to accessing care, including reproductive care, further complicate these health disparities. Interpersonal stigma within the healthcare system, and high rates of physical and sexual violence survivorship, make TGNB people particularly vulnerable to healthcare trauma and poor care. This is particularly true among TGNB people with multiple intersecting marginalized identities. Trauma-informed care provides a framework for medical practitioners to provide safe, holistic, and sensitive care. Scant academic literature discusses trauma-informed reproductive care for TGNB individuals. We present a narrative review of the evidence for trauma-informed reproductive care for TGNB people and suggest potential application and implementation.
Civilisation as a Sign: new perspectives in civilisation studies
Authors: Oukhvanova-Shmygova Irina F. , Ryushyna Lilia L. 
Published: November 2024

The problem of the future of the Eastern and Western civilizations has come to the fore in civilization studies. There are researchers who insist on the idea of their cooperation, which represents itself whether in a dialogue form (polilogue) or in the form of absorbing one civilization by another. There are also researchers who believe that civilizations do not have much in common, and which is why conflicts are unavoidable. As a result, there appeared four models of civilization development, namely: the Europe-centrism model, the model of the parallel development of the West and East, the model of the clash of civilizations and the model of cultural dialogue. Could they be viewed as something holistic but open to different realizations? The authors give the idea of a synthetic (or rather synergetic) approach to treating civilization development built with the help of the causal-genetic perspective.
Conjunctions in Polish sign language dictionaries and signed texts translated from Polish
Authors: Kozub Monika 
Published: November 2024

This study conducts a comparative analysis of conjunctions catalogued in Polish Sign Language (PJM) dictionaries, from historical to contemporary editions, and those used in actual PJM texts translated from Polish. The analysis includes dictionaries from the earliest known Słownik mimiczny dla głuchoniemych i osób z nimi styczność mających (1879) to the contemporary online Korpusowy słownik polskiego języka migowego UW (2016). The main focus of this article is to examine the frequency of certain PJM conjunctions in texts translated by an all-Deaf team. This is exemplified by the multimedia adaptation of the fifth-grade primary school textbook Jutro pójdę w świat 5 (2016), in which all texts are translated into PJM. The results aim to bridge the gap between lexicographical records and actual language use in the deaf community, and to highlight the dynamics of PJM development.
Deep Slip Rates Along the Fault Zones of the 1927 M 8 Gulang Earthquake Estimated from Repeating Microearthquakes
Authors: Li Le , Niu Fenglin , Chen Qi-Fu , Wang Jianjun 
Published: November 2024

Abstract
The 23 May 1927 M 8 Gulang earthquake is the largest historical earthquake along the Hexi Corridor at the northeastern edge of the Tibetan plateau. Because of few records and limited investigations, the seismogenic faults of this event and their regional deformation at depth remain unclear. The observations of repeating microearthquakes allow improved understanding of the variation in slip behavior and seismic potential around the seismogenic faults. We investigated deep slip rates along the fault zones where the devastating 1927 M 8 Gulang earthquake occurred with repeating earthquake sequences. We used waveform data recorded by three digital seismic networks from 2001 to 2019 and the second phase of the CHINArray deployment between February 2013 to March 2016. Because of the sparsity of the network in the study area, we employed an empirical method to constrain the relative distance between event pairs using S−P differential times measured at subsample precision. We identified a total of 14 sequences of repeating earthquakes and estimated fault-slip rates at seismogenic depths based on their sizes and recurrence intervals. The slip rates estimated at various parts of the fault zones vary from 0.6 to 7.5 mm/yr in the depth range of 4–15 km along the Huangcheng–Shuangta fault (HSF), ∼3.8 mm/yr at ∼10 km deep along the southern Wuwei basin fault, ∼0.4 mm/yr at a depth of ∼11 km along the Tianqiaogou–Huangyangchuan fault. The highest slip rate of 7.5 mm/yr was observed at the junction between the east end of HSF and the Wuwei–Tianzhu fault. Our results have significant implications to the understanding of the regional tectonic deformation as well as seismic risk assessment.
Hecho de la víctima como eximente de responsabilidad civil extracontractual
Authors: Córdova Vacas Emilio José , Proaño Vélez María Emilia 
Published: November 2024

En la búsqueda para la aplicación de la responsabilidad civil extracontractual uno de los elementos clave a analizar es la causalidad. Sin embargo, este requisito se dificulta ante la presencia de eximentes de responsabilidad. El presente trabajo pretende exponer las razones tanto fácticas como jurídicas por las que el hecho de la víctima, como eximente, no es eficiente. Se manifestará, entre otras razones, que el mismo incumple la función de distribución de infortunios, es inaplicable de acuerdo a las tesis de causalidad y desconoce la presunción del principio de buena fe. Además, se identifica una figura jurídica que puede sustituir su función. Para sustentar esta premisa se condensan importantes aportes doctrinarios, así como referencias a casuísticas ecuatorianas y nociones generales del derecho. Se concluye que no se contraviene, con la presente postura, a lo dispuesto en el ordenamiento ecuatoriano.
Cost Analysis of Fuzzy Discrete (s, S) Queueing Inventory System with Positive Lead Time and Optimization using Genetic Algorithm
Authors: Jain Mridula , Kumar Indeewar 
Published: November 2024

In this article, a queueing inventory model with discrete time (DQIM) FGEOM/FGEOM/1 with (s, S) replenishment policy incorporating fuzzy numbers as input parameters is considered. The system has a fuzzy pentagonal number arrival rate according to a Bernoulli process and a fuzzy pentagonal number service rate that follows a geometric distribution. Here, S represents the highest level of stock where the process of replenishment is stopped, and s represents the lowest level of stock at which replenishment is started again. Using matrix geometric method, the steady-state solution is obtained followed by derivation of various fuzzy performance measures. Further, the total cost function is defined as a two-variable function of the minimum and maximum stock level. Genetic algorithm is employed to optimize the total cost. Various examples are presented to highlight the dependence of cost on input parameters. The use of PFN in DQIS and genetic algorithm in the optimization of DQIS is introduced in this paper for the first time.
JEL Codes: C44, C61, C62, D11, D12, L89
Received: 17/07/2024. Accepted: 29/09/2024. Published: 04/10/24.
Use of a 2/3 Free Vascularized Fibula Flap for Tibiofibular Bone Defect Reconstruction
Authors: Zhang Xianfei , Yang Qiming , Luo Xu , Song Xiongbo , Fu Tianjun , Sun Li , Lei Yanwen , Chen Long 
Published: November 2024

Case:
A 40-year-old man with a tibiofibular bone defect caused by infection was treated using a 2/3 free vascularized fibula flap, which preserved 1/3 of the continuous periosteum and cortex of the fibula at the donor site, allowing for regeneration of fibular bone defect caused by bone harvesting procedure. At 16 months of follow-up, his bilateral lower limb function had recovered well.

Conclusions:
A 2/3 free vascularized fibula flap is an effective treatment approach for long-segment bone defects. This technique not only provides sufficient mechanical strength and stability at the defect site but also facilitates regeneration of the donor site fibula.
A Rapid Method for Determining Characteristics of Liquid Flow in Porous Media
Authors: Smith Frank W. 
Published: November 2024

To study the flow behavior of non-Newtonian solutions in porous media, a procedure was needed to rapidly measure solution mobility at a number of flow rates. An experimentally simple method was developed that has proved successful for obtaining data over a broad range of velocities and pressure gradients.
The only equipment required are a buret with shortened delivery tip, a holder for rock samples and an electric timer. To carry out measurements, a liquid-saturated rock sample is placed in the holder and the system (Fig. 1) is filled with a Newtonian liquid so that the rock permeability can be determined. After flow is started, measurement of elapsed time is begun the instant the falling liquid meniscus passes the uppermost buret graduation. Several volume-time readings are recorded until the liquid level in the buret has fallen to as low a value as wanted. Occasional adjustment of the outlet may be necessary to keep it level with the bottom buret graduation. The system is then flushed with the solution of interest and the foregoing procedure is repeated to obtain the solution mobility.
Rock samples such as that depicted in Fig. 1 were used in the form of thin discs mounted in epoxy resin. Ordinarily plugs 1 ¼-in. in diameter were cast in resin using a silicone-grease-coated, 2-in. diameter steel pipe as a mold. After the plug had been removed from the mold, it was cut into discs with a diamond abrasive wheel. Disc thicknesses of 1/8 in. had sufficient strength to endure normal handling. The extent of resin penetration into the edges of the discs was visible so that the area available for flow could be measured. The disc thickness was taken to be the average of several micrometer readings. This same mounting technique should be easily adapted to irregularly shaped rock samples.
Imino and benzimidazolinyl functionalized pyrano[2,3-b] quinoline as a dual-responsive probe for detection of mercury ion and phosgene
Authors: Dan Feijun , Tang qian , Chen xin , Liu liang 
Published: November 2024

Abstract

A dual-responsive probe 8-N,N-diethylamino-3-(1H-benzoimidazol-2-yl)-2H-pyrano[2,3-b]quinoline-2-imino (PQI), pyrano[2,3-b]quinoline as fluorophore, two nitrogen atoms as receptor sites, was developed for the colorimetric and fluorescence detection of Hg2+ and COCl2 in different solvents. PQI showed good recognition ability for Hg2+ via the absorbance decrease, fluorescence quenching by the formation of PQI-Hg2+ complex in MeOH/H2O (4/1, V/V). In addition, PQI could specifically react with COCl2 via intramolecular cyclization to form a cycle urea product, which exhibited absorption and fluorescence emission changes, and then realized the detection of COCl2. Moreover, the optical responses of PQI to Hg2+ and COCl2 featured high selectivity, fast response (within 30 s), and low detection limit (73 nM for Hg2+ and 25 nM for COCl2, respectively). Furthermore, PQI could detect Hg2+ in real water samples with good recoveries and small relative standard deviations, and could be prepared as a PQI-loaded test strip to monitor gaseous COCl2 in an in-site, real-time, highly sensitive manner, demonstrating the practicability of PQI in Hg2+ and gaseous COCl2 detection.
Application of low level laser therapy (Red laser 635 nm) and ultrasound therapy and a combination of (US/Laser 635 nm) therapy in patients with temporomandibular joint disorders (TMDs)
Authors: Mohammed Noor Q. , Mahdi Zainab F. , Abdulhameed Balsam S. 
Published: November 2024

Abstract

Purpose
This study aimed to compare and find out the best treatment method between Laser (635 ± 10 nm), (US) and a combination of (US/Laser 635 ± 10 nm) in treatment of Temporomandibular disorders (TMDs).
Methods
This prospective study was done at the Department of Oral and Maxillofacial Surgery, AL Imam Ali Hospital in Al-Sadr City, and the oral medicine clinic at specialized curve center in Baghdad from January to August 2024. The study was carried out on (75) TMD patients, (25) of them were treated with (Laser635 ± 10nm), (25) were treated with (US) and (25) were treated with a combination of (US/Laser 635 ± 10 nm) in four treatment sessions (two sessions every week). The average power in laser treatment was 0.3 Watts, irradiation time: 30 seconds on each tender point. The average power in US treatment was 0.5 Watts, and application time was 3 minutes. Numbers of tender points were measured by palpation, and mouth opening was measured by electronic digital caliper. Pain intensity was recorded on a scale from 1 to 10 using rating visual analog scale (VAS).
Results
The most common age group was (20–29) years among all age groups and the mean age was (28.7 ± 8.4) years, and female patients were highly dominated (85.3%) over males (14.7%). The (laser 635 ± 10 nm) group showed significantly lower pain intensity, larger mouth opening, when compared with US treated patients in all the 4 treatment sessions. As a comparison between groups at different time periods, before second session, laser (635 ± 10 nm) group had the lowest pain intensity (p = 0.000). Before third session, laser (635 ± 10 nm) group had the lowest pain intensity, followed by (US/laser635 ± 10 nm) group (p = 0.000). Mouth opening was significantly largest (P = 0.010) in laser (635 ± 10 nm) group, followed by (US/laser 635 ± 10 nm) group. Before fourth session, the same significant results regarding pain intensity and mouth opening were obtained (P = 0.000). One month later, the same previous significant results regarding pain intensity and mouth opening (P = 0.000) were achieved. Number of masseter tender points was significantly lower (P = 0.028) in (laser 635 ± 10 nm) group as compared with (US/Laser 635 ± 10 nm) group.
Conclusions
The treatment of TMD patients with (laser 635 ± 10 nm) was shown to be more effective than treatment with (US) and with a combination of (US/Laser635 ± 10 nm) in reducing pain intensity and mouth opening.
Optimum design for slip/no-slip configuration of hydrodynamic fluid film using Gradient method
Authors: Bayada Guy , Talibi Mohamed El Alaoui , HILAL Mouna 
Published: November 2024

Abstract

We study a non-convex, non-differentiable optimization problem in thin film lubrication, where the state equation is a variational inequality. The goal is to find the optimal partition of the surface of a lubricated device into slip and no-slip areas while considering cavitation. The existence of an optimal solution is proven through regularization/penalization techniques, and optimality conditions are derived. Cases of non-uniqueness are exhibited. Numerous detailed examples are presented for 1D and 2D situations. Comparisons are made between gradient methods involving computations of the adjoint problem, gradient methods using approximate gradients and genetic algorithms.
Static Scheduling Method for Aircraft Flat-tail Assembly Production Based on Improved Bi-level Genetic Algorithm
Authors: Li Tengda , Hua Min , Wang Junliang , Qin Wei 
Published: November 2024

Abstract

Aircraft flat-tail assembly is a complex process that involves multiple assembly processes, multiple parallel frames, and multi-configuration mixed flow assembly, thereby presenting a flexible flow-shop scheduling problem (FFSP), which is a typical NP-hard problem. Despite its significance, the research on FFSP in aircraft flat-tail assembly production scheduling is limited. This study proposes an improved bi-level genetic algorithm to address the two sub-problems of flat-tail assembly production scheduling: frame assignment and assembly task sequencing. The objective is to minimize the maximum delay penalty cost. A two-stage coding scheme is introduced for frame assignment and task sequencing, respectively. To address the tendency of genetic algorithms to converge to local optima and lack positive feedback, a variable neighborhood search mechanism and elite retention strategy are applied. The efficacy of the improved bi-level genetic algorithm is evaluated through experiments and case studies in enterprises, indicating a significant impact on the assembly production scheduling of flat-tail, with potential applications to similar large and complex equipment. Overall, this study contributes to FFSP research in aircraft flat-tail assembly production scheduling by offering a novel solution approach to effectively address the sub-problems of frame assignment and assembly task sequencing.
Molecular basis of attack patterns during cock fighting
Authors: Shimmura Tsuyoshi , Kurachi Takuma , Rafati Nima , Shimura Kohei , Goto Tatsuhiko , Kawakami Shin-Ichi , Maeda Rikuto , Pettersson Mats E. , Matsuda Yuki , Yamada Yohei , Nakamura Yoshiaki , Higashiura Yuki , Shimura Nonoko N. , Bendesky Andres , Tsudzuki Masaoki , Andersson Leif 
Published: November 2024

Abstract

Aggression is an essential animal behaviour for survival, particularly in situations where fighting cannot be avoided. In such situations, the choice of attack pattern (i.e. biting, charging, or defending) is critical. However, the molecular basis underlying attack pattern preferences remains unknown. Here, we utilise two subpopulations of chickens bred for cockfighting, showing markedly different attack patterns: offensive and defensive attack. Whole-genome sequencing of individuals from these populations identified 15 genes, 5 of which - including the gene for the transcription factor FOXP1 - are associated with neuronal development in the brain. Furthermore, functional genomics, including RNA sequencing and immunohistochemistry, suggested that activation of the indirect pathway of the brain motor circuit, under the control of FOXP1, resulted in a defensive attack, which was supported by behavioural pharmacology. Taken together, our results indicate that genetic mutations in neurodevelopment-related genes cause an altered motor pathway, which changes attack patterns.
Evaluation of xylose assimilation by a strain of Desmodesmus sp. and the use of sugarcane bagasse hydrolysate as a carbon source for algal biomass production.
Authors: Sartori Marina Lemos , Pantoja Lílian de Araújo , Santos Alexandre Soares 
Published: November 2024

Abstract

Desmodesmus is a fast-growing photosynthetic microalga and is considered a promising feedstock due to its potential to produce protein, polysaccharides, and unsaturated fatty acids. However, the economic viability of bio-based products from microalgae depends on reducing the cost of cultivation. Some microalgae species can utilize low-cost agro-industrial and urban wastes to grow and produce desirable bioproducts. The objective of this study was to evaluate the ability of the freshwater microalga Desmodesmus sp. strain to utilize xylose and sugarcane bagasse hydrolysate as carbon sources to grow and accumulate oil, starch, and proteins. The effects of different growth conditions, including photoautotrophic, mixotrophic, and heterotrophic growth, were investigated. The productivity data obtained with xylose indicate that Desmodesmus sp. has a industrial profile for all targeted biobased contents under mixotrophic culture conditions. When grown on dilute sugarcane bagasse hydrolysate, the Desmodesmus sp. strain produced 47.6%, 5.0%, and 10.1% of protein, starch, and oil, respectively, based on its dry cell mass. This work demonstrated that the Desmodesmus strain evaluated could utilize xylose as the sole carbon source and utilize the sugars, including xylose, glucose, and arabinose, present in sugarcane bagasse hydrolysate, a potential co-product of second-generation ethanol plants in Brazil.
Gravity with agricultural data: Estimating the impacts of deep trade agreements
Authors: Lin Xin , Li Donglin , Xie Huimin , Jia Wei 
Published: November 2024

Abstract

Modern Preferential Trade Agreements (PTAs) extend beyond simple tariff reductions, incorporating a range of provisions that emphasize deeper commitments related to non-tariff barriers and behind-the-border policies. This complexity complicates the assessment of their impacts on agricultural trade. By integrating data from the Deep Trade Agreements (DTAs) database and the UN Comtrade database, our study investigates the effects of deepening agricultural provisions in DTAs on agricultural trade. The analysis utilizes an extended three-way structural gravity model with a panel dataset covering 225 countries. Compared to ''shallow'' PTAs, DTAs with detailed provisions significantly boost agricultural trade, with the average effect varying according to the income levels of partner countries and aggregated product levels. However, the capacity of DTAs to promote trade is not fully leveraged in the post-pandemic period due to heightened market uncertainty. The findings highlight the roles of behind-the-border provisions in agricultural trade integration.
JEL Classification: F13 , F14 , Q17 , C23