bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and ultrasonographic evaluation of three suture techniques for closure of the equine linea alba
Authors: Verkade M. E. , Ugahary F. , Martens A. , Wiemer P. 
Published: May 2019

SummarySurgical technique plays an important role in preventing ventral midline incisional complications. The aim of this study was to compare the clinical and ultrasonographic outcome of three suture techniques for closure of the linea alba. In this prospective case series (n = 43), horses operated for acute abdominal intestinal disease through a midline incision were randomised in three groups: closure with a conventional continuous technique (Group 1), a small stitches continuous technique (Group 2) and theUX‐technique (shoe‐lace configuration, Group 3). Age, sex, body weight, type and duration of surgery were recorded and the suture to wound length ratio was calculated. Clinical evaluation of the wound (wound discharge) was performed daily during hospitalisation. At 7 weeks post‐operatively the linea alba was evaluated clinically and ultrasonographically. The linea alba width was measured halfway along the length of the incision. One horse in Group 1 had acute incisional dehiscence, but there were no further significant differences between the groups in the short term. Seven weeks post‐operatively two horses had complete herniation in Group 1 and one horse had partial herniation in Group 2. In theUXgroup no herniation occurred. The incidence of herniation was not significantly different between the groups. On ultrasound at 7 weeks the linea alba width was significantly smaller in Group 2 (P = 0.00029) and Group 3 (P = 0.0018) compared with Group 1, even with exclusion of the acute incisional dehiscence and two herniated horses. Limitations were the small group size and relatively low incidence of incisional complications for statistical analysis. It was concluded that the use of small stitches and theUX‐technique resulted in a smaller linea alba width compared with the conventional continuous suture technique and might therefore be preferred for closure of the linea alba in equine colic surgery.
E‐cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions
Authors: Nelson Amanda M. , Cong Zhaoyuan , Gettle Samantha L. , Longenecker Amy L. , Kidacki Michal , Kirby Joslyn S. , Adams David R. , Stairs Douglas B. , Danby Frederick W. 
Published: May 2019

AbstractHidradenitis suppurativa (HS) is a chronic, inflammatory skin disease affecting the pilosebaceous units in the axilla, groin and buttocks. While the pathogenesis of HS is not clear, mechanical stress exacerbates HS. In this study, we aimed to determine whether intracellular adhesive junctions may be aberrant in HS patient skin. Strikingly, we observed loss of E‐cadherin and p120ctn protein expression, two key adherens junction proteins, in ~85% of HS severe skin lesions. Moreover, loss of protein expression was apparent in non‐lesional skin from HS patients and the degree of loss positively correlated with HS Hurley Stage of disease. E‐cadherin expression was unaltered in other inflammatory skin conditions including chronic wound epithelium, atopic dermatitis, and acne vulgaris compared with healthy skin suggesting that its loss may be uniquely relevant to HS pathogenesis. A complete loss of α‐catenin, β‐catenin and ZO‐1 was not observed; however, some cytoplasmic staining of the catenins was noted in HS epithelium. We also demonstrated diminished desmosome size in HS lesional skin. Overall, our data suggested that loss of adherens junction proteins and diminished desmosome size in HS skin contributes to the skin's inability to withstand mechanical stress and provides rationale as to why mechanical stress exacerbates HS symptoms.
Data quality and quantity for invasive species: A case study of the lionfishes
Authors: Lyons Timothy J. , Tuckett Quenton M. , Hill Jeffrey E. 
Published: May 2019

AbstractPredicting invasion risk involves inherent uncertainty when data on biological and ecological characteristics are lacking. To combat data gaps, assessors are required to use information from secondary sources, further reducing predictive accuracy. Lionfish in the subfamily Pteroinae have invasion history in the Western Atlantic Ocean and Mediterranean Sea, raising concern that other species of globally traded lionfish may pose risks similar to the invasive complex comprised of the red lionfish (Pterois volitans, Scorpaenidae) and devil firefish (Pterois miles, Scorpaenidae). We conducted a standardized literature review of 18 species in the genera Pterois, Dendrochirus, and Parapterois to (a) characterize the volume and composition of literature addressing the invasive complex pre‐establishment and pre‐spread, and compare it to the body of literature that has been generated post‐spread and impact, (b) compare the volume and composition of literature addressing other members of Pteroinae to the invasive complex, and (c) evaluate data quality addressing the Pteroinae by characterizing literature used to generate biological profile reports during a risk screening protocol. Little data were available for the invasive complex prior to introduction and focused primarily on the composition or effects of venom. Following introduction, there was a considerable time lag in research effort. Post‐spread, research effort increased rapidly. We identify similar data deficiencies for other species of lionfish that have not been reported outside of their native ranges. While proactive management is gaining support as an effective framework, it is important to understand data limitations and their resulting uncertainties, which leads to more informed proactive management.
Gait asymmetry assessment for older adults by measuring circular gait speed
Authors: Ichihashi Noriaki , Ikezoe Tome , Sato Syunsuke , Ibuki Satoko 
Published: May 2019

AimThe aim of the present study was to evaluate the effectiveness of the circular gait test as a method for detecting side‐to‐side straight‐line gait asymmetry in older adults.MethodsA total of 25 healthy older adults and 20 healthy young adults participated in this study. Walking speeds, right‐ and left‐leg step lengths, and stance durations were measured during straight‐line walking using a triaxial accelerometer (G‐walk from Bertec Japan). Step length and stance duration laterality were calculated using the side‐to‐side difference (|Left – Right|) and asymmetry index (|Left − Right| / mean right and left values × 100). For circular gait, the time required to walk twice around a 1‐m diameter circle for right and left rotations was measured, and the laterality was calculated using the same formula as that described for the straight‐line gait.ResultsThe results showed no differences in straight‐line step length or stance duration laterality between groups. However, circular gait asymmetry was significantly higher for older participants. A significant correlation was confirmed between circular gait time and straight‐line step length for older adults (r = 0.404).ConclusionsThe present study suggested that the circular gait test had better potential to detect age‐related changes in gait laterality than straight‐line gait step length or stance duration, and it might work as a simple assessment method for detecting laterality in straight‐line walking. Geriatr Gerontol Int 2019; 19: 736–739.
Crypto‐coin hierarchies: social contestation in blockchain networks
Authors: BOUSFIELD DAN 
Published: May 2019

AbstractIn this article, I discuss the role of crypto‐coins (CCs) as an explicit response to the 2008 economic crisis. Drawing on networked social movement theory, I outline the tension between blockchain based currencies promoted as horizontal markets of technological innovation and the persistence of hierarchical authority within these networks. By examining the assumptions about authority and regulation that underpin the creation of CCs I argue that the cryptographic responses to the financial crisis understate the persistence of hierarchies in their claims to upset traditional monetary authority. As global networks, blockchain technology faces political challenges from regulators, hegemonic market actors and adherents devoted to particular CCs. Consequently, I draw parallels between CCs and networked social movements to argue that the emergence and proliferation of ‘altcoins’ presents a series of political challenges to the framing of CCs as disruptive technology. The innovative character of CCs relies on tacit and explicit assumptions about politics that social movement theory can help to explain. By examining the altcoins through the concepts of resource mobilization, framing and identity formation, I argue that the dynamics of offline social hierarchies persist and are magnified in the world of CCs.
Post‐traumatic stress disorder and dementia in veterans: A scoping literature review
Authors: Ritchie Kim , Cramm Heidi , Aiken Alice , Donnelly Catherine , Goldie Katie 
Published: May 2019

AbstractEmerging research has found an association between post‐traumatic stress disorder (PTSD) and dementia in veterans, yet little is known about the nature of this association and how it is conceptualized in the literature. The purpose of this scoping review is to understand how the relationship between PTSD and dementia in veterans is recognized and described in the peer‐reviewed literature. A scoping review was conducted using Arksey and O'Malley's (International Journal of Social Research Methodology, 8, 19, 2005) framework. Articles are included if participants were veterans with a focus on PTSD and dementia. A total of six databases (CINAHL, MEDLINE, EMBASE, PsycINFO, HealthSTAR, and PubMed) were searched along with the reference lists of eligible sources in September 2018. Thematic analysis was used to summarize the data. Thirty‐six studies were included in this review. Three main themes emerged from the literature: (i) symptomatic expression of PTSD and dementia; (ii) aetiology underlying the relationship between PTSD and dementia; and (iii) implications of PTSD and dementia on healthcare providers, treatment, and resources. This study highlights the ongoing need to understand mechanisms underlying the association between PTSD and dementia, the need for definition of PTSD symptoms, and to sensitize healthcare providers to the presence of PTSD when caring for veterans with dementia.
Support of adolescents to resist peer pressure and coercion to sexual activity
Authors: Mashia E.O. , van Wyk N.C. , Leech R. 
Published: May 2019

AimThe aim of this study was to explore and describe how peer pressure and coercion to sexual activity manifested among adolescents in a district in South African and how primary healthcare nurses could support them to resist it.BackgroundWhen adolescents engage in early sexual activity, unplanned pregnancies and sexual transmitted infections become health threats. Notwithstanding the governmental health promotion programmes to improve the sexual health of the youth in South Africa, adolescents are still having unprotected sex and even multiple sex partners.MethodsA constructivist grounded theory study was done. The initial sample consisted of 10 adolescents and nine professional nurses who were selected from six primary healthcare clinics in the identified district. Constant comparative data collection and analysis were done to identify the initial codes that were theoretically saturated through another round of data collection and analysis involving five participants (four professional nurses and one health educator).FindingsThe findings of the study refer to the definition of peer pressure and coercion and the relationship between professional nurses and adolescents. Ways to optimize the relationship in order for nurses to substitute for parental shortcomings in guiding adolescents towards responsible sexual behaviour and to address the adolescents’ vulnerability regarding peer pressure were identified.ConclusionChallenging adolescent–nurse interaction incidents were identified that warranted different approaches to build on existing initiatives to improve adolescent‐friendly health services.Implications for nursing practice and policyPrimary healthcare nurses should perform complementary roles to substitute for parents who do not have the skills to guide their adolescent children towards responsible sexual behaviour. Programmes need to be developed to enable nurses to optimize their relationships with adolescents and to deliver services through mobile healthcare units to adolescents where they regular socialize. Management should provide budgets for nurses to use multimedia to interact with adolescents.
Acculturation, acculturative stress and resilience among older immigrants in United States
Authors: Serafica R. , Lekhak N. , Bhatta T. 
Published: May 2019

BackgroundPrevious studies have demonstrated a strong and consistent association between higher acculturative stress and poorer mental and physical health outcomes while acculturating to a new country. Acculturative stress is multifactorial and nurses work in variety of settings that encounter older immigrants with different levels of acculturative stress. Research on resilience among older immigrants has linked resilience to successful acculturation.PurposeThe aim of this study was to explore the interplay between acculturation, acculturative stress and resilience, and their collective impact on physical and mental health self‐evaluation among older Filipino Americans.MethodThis study employed a cross‐sectional, quantitative, descriptive design using older Filipino immigrants, 55 years and older (N = 123) who were living in the western part of the United States.FindingsOur study found that the levels of acculturation did not have a significant influence on self‐evaluation of physical and mental health; however, acculturative stress and resilience had an indirect effect on physical and mental health.ConclusionsThis study reemphasized the importance of assessing the acculturative stress and determining resiliency among older immigrants who might be undergoing acculturation‐based conflicts with their families and community. Promoting a low level of acculturative stress and high resilience is key to shaping interventions to obtain better health outcomes among this population.Implications for nursing policyNurses can support and augment the efforts of professional nursing organizations to advocate and encourage legislation and policy to improve the physical and mental well‐being of older immigrants. Policymakers should focus on additional resources for older adults from other countries to reduce their stress or enhance their resilience.
Multi‐omics integrative analysis identified SNP‐methylation‐mRNA: Interaction in peripheral blood mononuclear cells
Authors: Lu Yi‐Hua , Wang Bing‐Hua , Jiang Fei , Mo Xing‐Bo , Wu Long‐Fei , He Pei , Lu Xin , Deng Fei‐Yan , Lei Shu‐Feng 
Published: May 2019

AbstractGenetic variants have potential influence on DNA methylation and thereby regulate mRNA expression. This study aimed to comprehensively reveal the relationships among SNP, methylation and mRNA, and identify methylation‐mediated regulation patterns in human peripheral blood mononuclear cells (PBMCs). Based on in‐house multi‐omics datasets from 43 Chinese Han female subjects, genome‐wide association trios were constructed by simultaneously testing the following three association pairs: SNP‐methylation, methylation‐mRNA and SNP‐mRNA. Causal inference test (CIT) was used to identify methylation‐mediated genetic effects on mRNA. A total of 64,184 significant cis‐methylation quantitative trait loci (meQTLs) were identified (FDR < 0.05). Among the 745 constructed trios, 464 trios formed SNP‐methylation‐mRNA regulation chains (CIT). Network analysis (Cytoscape 3.3.0) constructed multiple complex regulation networks among SNP, methylation and mRNA (eg a total of 43 SNPs simultaneously connected to cg22517527 and further to PRMT2, DIP2A and YBEY). The regulation chains were supported by the evidence from 4DGenome database, relevant to immune or inflammatory related diseases/traits, and overlapped with previous eQTLs from dbGaP and GTEx. The results provide new insights into the regulation patterns among SNP, DNA methylation and mRNA expression, especially for the methylation‐mediated effects, and also increase our understanding of functional mechanisms underlying the established associations.
The exploration of mechanisms of comorbidity between migraine and depression
Authors: Zhang Qing , Shao Anwen , Jiang Zhengyan , Tsai Huitzong , Liu Weibo 
Published: May 2019

AbstractMigraine comorbid with depression is common and is often encountered in clinical practice. The comorbidity may lead to more serious conditions with other symptoms and a longer duration of treatment and it may impose heavy economic and social burdens, directly or indirectly, on patients and their families. Numerous studies have been published on the association of migraine with depression. Numerous literature have showed that the comorbidity may have a common complicated pathogenic mechanism involving biopsychosocial characteristics, including abnormal brain development and shared genetic basis, as well as neurotransmitters, sex hormones and stress. In addition, some studies have identified the multiple, bidirectional relationship between migraine and depressive disorder. We searched the literature for the possible common mechanisms between migraine and depression and classified the research results.
Toward a dynamic evaluation of mineral criticality: Introducing the framework of criticality systems
Authors: Yuan Ye , Yellishetty Mohan , Muñoz Mario A. , Northey Stephen A. 
Published: May 2019

AbstractA new methodology to quantify minerals’ criticalities is proposed—the criticality systems of minerals. In this methodology, four types of agents—mineral suppliers, consumers, regulators of the market, and others, such as the communities near mining operations—interact with each other through three types of indicators: constraints, such as the political stability in the mining regions, the mineral's substitutability and economic importance; agents’ interactions, such as buyer–seller bargaining; and interactive variables, such as the demand, supply, and price. When the criticality systems of two mineral groups are constructed, analyses that compare the indicators of these criticality systems can determine which group is more critical than the other. This methodology allows evaluation of criticality in a dynamic and systemic manner.
The role of pericytes in brain disorders: from the periphery to the brain
Authors: Hirunpattarasilp Chanawee , Attwell David , Freitas Felipe 
Published: May 2019

AbstractIt is becoming increasingly apparent that disorders of the brain microvasculature contribute to many neurological disorders. In recent years it has become clear that a major player in these events is the capillary pericyte which, in the brain, is now known to control the blood–brain barrier, regulate blood flow, influence immune cell entry and be crucial for angiogenesis. In this review we consider the under‐explored possibility that peripheral diseases which affect the microvasculature, such as hypertension, kidney disease and diabetes, produce central nervous system (CNS) dysfunction by mechanisms affecting capillary pericytes within the CNS. We highlight how cellular messengers produced peripherally can act via signalling pathways within CNS pericytes to reshape blood vessels, restrict blood flow or compromise blood–brain barrier function, thus causing neuronal dysfunction. Increased understanding of how renin–angiotensin, Rho‐kinase and PDGFRβ signalling affect CNS pericytes may suggest novel therapeutic approaches to reducing the CNS effects of peripheral disorders.
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Evaluation of physician volumetric accuracy during hyaluronic acid gel injections: An observational, proof‐of‐concept study
Authors: Enright Kaitlyn M. , Sampalis John , Nikolis Andreas 
Published: May 2019

AbstractBackgroundFindings indicate that standard injection techniques for hyaluronic acid (HA) soft tissue fillers result in considerable variations in the applied boluses. Furthermore, despite the knowledge that the varying biophysical properties of HA fillers (eg, G′, cohesivity, viscoelasticity) can affect their ease of injection, the impact of device attributes on an injector's volumetric accuracy is currently unknown.Objectives(a) Evaluate the ability of aesthetic physicians to accurately inject a specific amount of HA filler; (b) investigate the effect of physician experience on injection accuracy; and (c) investigate the impact of different HA gel properties on an injector's performance.MethodsThirteen physicians with aesthetic experience were recruited. Subjects were blindfolded and asked to deposit 0.2 cc of four HA fillers under two conditions: (a) onto a scale and (b) into a porcine membrane. The amount of gel deposited/injected was then measured. An accurate injection was defined as 0.2 cc ± 15%.ResultsSubjects were rarely able to dispense accurate amounts of injectate (42/208 injections or 20.19%) and often underestimated their injection quantities. Variations in the accuracy distributions between groups were observed. An injector's experience, the conditions under which injections were performed and the product choice were all variables found to affect the accuracy distributions.ConclusionsThe findings of this study provide evidence that the use of visual and/or audible stimuli is necessary for dispensing accurate volumes. This has clinical implications for treatment efficacy and patient satisfaction during free hand injections. To ensure more accurate and reproducible results, the investigators propose a possible modification to the standard injection technique.
Sertoli–Leydig cell tumor of the ovary: Analysis of a single institution database and review of the literature
Authors: Durmuş Yasin , Kılıç Çiğdem , Çakır Caner , Yüksel Dilek , Boran Nurettin , Karalök Alper , Boyraz Gökhan , Turan Ahmet T. 
Published: May 2019

AbstractAimTo evaluate the clinical characteristics and outcome of ovarian Sertoli–Leydig cell tumors (SLCTs) managed at a single institution.MethodsThe hospital records of 17 patients with the diagnosis of ovarian SLCT between 1994 and 2018 were reviewed retrospectively.ResultsThe median age of the patients was 30 years (range, 18–67 years). All the patients had unilateral tumors. All of the 17 were stage 1 tumors. Two (11.8%) patients were stage 1C1 and two (11.8%) patients were stage 1C2. Thirteen (76.5%) patients were stage 1A. Three (17.6%) of the tumors were well differentiated, 11 (64.7%) were intermediately differentiated, 1 (5.9%) was poorly differentiated, and the degree of the differentiation was not identified for 2 (11.8%) patients. One showed retiform pattern and one had heterologous elements at the histopathologic evaluation. Among the 17 patients, we identified structural/vascular renal and ureteral anomalies in 3 (17.6%) patients. Eight patients underwent total abdominal hysterectomy and bilateral salpingo‐oophorectomy, seven underwent unilateral salpingo‐oophorectomy or oophorectomy and two underwent cystectomy with or without additional surgical staging procedures. Four patients received adjuvant chemotherapy. All the 17 patients were alive and free of disease for 1–287 months after the diagnosis. Median follow‐up time was 78 months. None of the patients recurred.ConclusionSertoli–Leydig cell tumors are rare ovarian malignancies with low recurrence rates and have a favorable outcome compared to malignant epithelial tumors of the ovary. Main treatment is surgical resection and it is appropriate to prefer fertility sparing conservative surgeries for young patients.