bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bandlimited Multipliers on Matrix-Weighted $$L^p$$-Spaces
Authors: Nielsen Morten 
Published: December 2024

Abstract
We extend a classical result by Triebel on boundedness of bandlimited multipliers on

$$L^p({\mathbb R}^n)$$

L
p

(

R

n

)

,

$$0<p\le 1$$

0
<
p
≤
1

, to a vector-valued and matrix-weighted setting with boundedness of the bandlimited multipliers obtained on

$$L^p(W)$$

L
p

(
W
)

,

$$0<p\le 1$$

0
<
p
≤
1

, for matrix-weights

$$W:{\mathbb R}^n\rightarrow \mathbb {C}^{N\times N}$$

W
:

R

n

→

C

N
×
N

that satisfy a matrix Muckenhoupt

$$A_p$$

A
p

-condition.
The multisensory control of sequential actions
Authors: Säfström Daniel 
Published: December 2024

Abstract
Many motor tasks are comprised of sequentially linked action phases, as when reaching for, lifting, transporting, and replacing a cup of coffee. During such tasks, discrete visual, auditory and/or haptic feedback are typically associated with mechanical events at the completion of each action phase, as when breaking and subsequently making contact between the cup and the table. An emerging concept is that important sensorimotor control operations, that affect subsequent action phases, are centred on these discrete multisensory events. By predicting sensory feedback at the completion of action phases, and comparing with the actual feedback that arises, task performance can be continuously monitored. If errors are detected, the sensorimotor system can quickly respond with task-protective corrective actions. The aim of this study was to investigate how discrete multisensory feedback at the completion of action phases are used in these control operations. To investigate this question, 42 healthy human participants (both male and female) performed a visually guided sequential reaching task where auxiliary discrete visual, auditory and/or haptic feedback was associated with the completion of action phases. Occasionally however, this feedback was removed in one or two modalities. The results show that although the task was visually guided, its control was critically influenced by discrete auditory and haptic feedback. Multisensory integration effects occurred, that enhanced the corrective actions, when auditory feedback was unexpectedly removed along with haptic or visual feedback. This multisensory enhancement may facilitate the ability to detect errors during sequential actions and amplify task-protective corrective actions.
Optimum blue light exposure: a means to increase cell-specific productivity in Chinese hamster ovary cells
Authors: Föller Stefanie , Regett Niklas , Lataster Levin , Radziwill Gerald , Takors Ralf 
Published: December 2024

Abstract
Research for biopharmaceutical production processes with mammalian cells steadily aims to enhance the cell-specific productivity as a means for optimizing total productivities of bioreactors. Whereas current technologies such as pH, temperature, and osmolality shift require modifications of the cultivation medium, the use of optogenetic switches in recombinant producer cells might be a promising contact-free alternative. However, the proper application of optogenetically engineered cells requires a detailed understanding of basic cellular responses of cells that do not yet contain the optogenetic switches. The knowhow of ideal light exposure to enable the optimum use of related approaches is missing so far. Consequently, the current study set out to find optimum conditions for IgG1 producing Chinese hamster ovary (CHO) cells which were exposed to blue LED light. Growth characteristics, cell-specific productivity using enzyme-linked immunosorbent assay, as well as cell cycle distribution using flow cytometry were analyzed. Whereas too harsh light exposure causes detrimental growth effects that could be compensated with antioxidants, a surprising boost of cell-specific productivity by 57% occurred at optimum high light doses. The increase coincided with an increased number of cells in the G1 phase of the cell cycle after 72 h of illumination. The results present a promising new approach to boost biopharmaceutical productivity of mammalian cells simply by proper light exposure without any further optogenetic engineering.

Key points
• Blue LED light hinders growth in CHO DP-12 cells
• Antioxidants protect to a certain degree from blue light effects
• Illumination with blue LED light raises cell-specific productivity
Magnetization-transfer flow-independent dark-blood delayed enhancement cardiac MRI optimizes discrimination of ST-elevation myocardial infarct borders
Authors: Poskaite Paulina , Kremser Christian , Pamminger Mathias , Troger Felix , Reiter Gert , Reinstadler Sebastian J. , Metzler Bernhard , Rehwald Wolfgang G. , Kim Raymond J. , Mayr Agnes 
Published: December 2024

Abstract
Objectives
To prospectively compare image quality and infarct sizing methods between magnetization-transfer “flow-independent dark-blood delayed enhancement” (MT-FIDDLE) and standard “bright-blood”-late gadolinium enhancement (LGE) cardiac-magnetic-resonance (CMR) sequence.

Methods
“Bright-blood”-LGE and MT-FIDDLE sequence were acquired in 110 patients at 4 days (n = 33), 4 months (n = 39) and 12 months (n = 38) after acute ST-elevation myocardial infarction (STEMI). Subjective image quality, including confidence in infarct segmentation and blood-pool bordering, were each rated on a 4-point Likert scale. Objective image quality was assessed by the detectability index (DI). Infarct volumes derived via full-width at half-maximum (FWHM) and different number of standard deviations (“n-SD”) methods on MT-FIDDLE images were compared with FWHM and reference 5-SD results from “bright-blood-LGE images.

Results
Overall subjective median image quality was excellent for both LGE sequences. Qualitative analysis revealed a significantly higher confidence in infarct segmentation and in blood-pool bordering for MT-FIDDLE as compared to “bright-blood”-LGE (all p < 0.001). Infarct volumes assessed by the FWHM technique on MT-FIDDLE and “bright-blood”-LGE showed excellent agreement overall (Concordance correlation coefficient, CCC = 0.96). The 3-SD technique for MT-FIDDLE showed the best agreement with the 5-SD method for “bright-blood”-LGE overall (CCC = 0.94), as well as in the subgroup with excellent confidence in infarct segmentation on “bright-blood”-LGE (CCC = 0.96). DI of scar versus LV blood-pool was higher for MT-FIDDLE (8.9 ± 5.5) compared to “bright-blood”-LGE sequence (2.0 ± 1.5; p < 0.001).

Conclusion
MT-FIDDLE significantly optimizes the discrimination between myocardial infarction and adjacent blood-pool in STEMI patients. As compared to the established 5-SD technique on “bright-blood”-LGE, the 3-SD method on MT-FIDDLE results in consistent infarct volumes.

Key Points
QuestionDoes magnetization-transfer “flow-independent dark-blood delayed enhancement” (MT-FIDDLE) offer any benefits over standard “bright-blood”-late gadolinium enhancement (LGE) cardiac-magnetic-resonance (CMR) for identifying STEMI infarct borders?
FindingsMT-FIDDLE image quality was higher than LGE CMR and measured infarct volume comparability to the standard 5-SD-threshold-technique.
Clinical relevanceMT-FIDDLE facilitates the assessment of myocardial infarctions at the subendocardial border, improving the discrimination between myocardial infarction and adjacent blood-pool in STEMI patients.
Predictors of outcomes in infants with gastroschisis treated with a preformed silo
Authors: Lee Rebecca , Dassios Theodore , Ade-Ajayi Niyi , Davenport Mark , Hickey Ann , Greenough Anne 
Published: December 2024

Abstract
Purpose
To describe the outcomes of infants with gastroschisis treated with a preformed silo (PFS) and determine whether routinely measured early physiological parameters, sepsis (blood culture positive), gastroschisis complexity or location of birth influenced the length of stay (LOS) and duration of parenteral nutrition (PN).

Methods
Infants cared for in a tertiary surgical neonatal intensive care unit during a 10-year period were identified.

Results
Seventy-seven infants were assessed [median gestational age 36 + 6 (IQR 35 + 3 to 38 + 0)] weeks. All survived; 82% were inborn. The median LOS was 37 (IQR 28–76.5) days and duration of PN was 28 (IQR 21–53) days. In the first 72 h, the worst median lactate, base excess and ‘toe-core’ gap were 4.2 (IQR 3.0–5.8) mmol/l, -7.0 (IQR − 5.55 to − 9.35), 3.4 (IQR 3.0–4.2) °C respectively. There were no significant correlations between early physiological parameters or place of birth and LOS or PN days, but sepsis (n = 18 infants) and complex gastroschisis (n = 13 infants) were associated with an increased LOS and PN duration (both p < 0.001).

Conclusions
Survival was 100% in infants with gastroschisis who were managed with PFS, sepsis and gastroschisis complexity were associated with a longer hospital stay and duration of parenteral nutrition.
Level of Evidence (I-V): IV.
Exercise training-induced speeding of $${\dot{\text{V}}\text{O}}_{{2}}$$ kinetics is not intensity domain-specific or correlated with indices of exercise performance
Authors: Inglis Erin Calaine , Rasica Letizia , Iannetta Danilo , Sales Kate M. , Keir Daniel A. , MacInnis Martin J. , Murias Juan M. 
Published: December 2024

Abstract
Purpose
This study examined the effect of 3 and 6 weeks of intensity domain-based exercise training on $${\dot{\text{V}}\text{O}}_{{2}}$$

V
˙

O

2

kinetics changes and their relationship with indices of performance.

Methods
Eighty-four young healthy participants (42 M, 42 F) were randomly assigned to six groups (14 participants each, age and sex-matched) consisting of: continuous cycling in the (1) moderate (MOD)-, (2) lower heavy (HVY1)-, and (3) upper heavy-intensity (HVY2)- domain; interval cycling in the (4) severe-intensity domain (i.e., high-intensity interval training (HIIT), or (5) extreme-intensity domain (i.e., sprint-interval training (SIT)); or (6) control (CON). Training participants completed two three-week phases of three supervised sessions per week, with physiological evaluations performed at PRE, MID and POST intervention. All training protocols, except SIT, were work-matched.

Results
There was a significant time effect for the time constant ($$\tau {\dot{\text{V}}\text{O}}_{{2}}$$

τ

V
˙

O

2

) between PRE (31.6 ± 10.4 s) and MID (22.6 ± 6.9 s) (p < 0.05) and PRE and POST (21.8 ± 6.3 s) (p < 0.05), but no difference between MID and POST (p > 0.05) and no group or interaction effects (p > 0.05). There were no PRE to POST differences for CON (p < 0.05) in any variables. Despite significant increases in maximal $${\dot{\text{V}}\text{O}}_{{2}}$$

V
˙

O

2

($${\dot{\text{V}}\text{O}}_{{{\text{2max}}}}$$

V
˙

O

2max

), estimated lactate threshold (θLT), maximal metabolic steady state (MMSS), and peak power output (PPO) for the intervention groups (p < 0.05), there were no significant correlations from PRE to MID or MID to POST between $$\Delta \tau {\dot{\text{V}}\text{O}}_{{2}}$$

Δ
τ

V
˙

O

2

and $$\Delta {\dot{\text{V}}\text{O}}_{{{\text{2max}}}}$$

Δ

V
˙

O

2max

(r = – 0.221, r = 0.119), ΔPPO (r = – 0.112, r = – 0.017), ΔθLT (r = 0.083, r = 0.142) and ΔMMSS (r = – 0.213, r = 0.049)(p > 0.05).

Conclusion
This study demonstrated that (i) the rapid speeding of $${\dot{\text{V}}\text{O}}_{{2}}$$

V
˙

O

2

kinetics was not intensity-dependent; and (ii) changes in indices of performance were not significantly correlated with $$\Delta \tau {\dot{\text{V}}\text{O}}_{{2}}$$

Δ
τ

V
˙

O

2

.
Reappraisal of soft tissue myoepithelial tumors by DNA methylation profiling reveals an epigenetically distinct group of mostly fusion-driven neoplasms
Authors: Malik Faizan , Koo Selene C. , Din Nasir Ud , Tran Quynh T. , Lopez-Nunez Oscar , Barresi Sabina , Vallese Silvia , Milano Giuseppe , Miele Evelina , Clay Michael R. , Alaggio Rita , Orr Brent A. 
Published: December 2024

AbstractSoft tissue myoepithelial tumors (METs) are diagnostically challenging tumors that require careful histologic and immunohistochemical characterization for accurate classification. Nearly half of METs show recurrent EWSR1 or FUS gene rearrangements with a diverse set of fusion partners. The diversity of fusion partners and lack of known driver abnormalities in many cases raises the question of whether METs represent a uniformly distinct tumor entity. To address this question, we performed careful histopathologic and molecular analysis, including DNA methylation profiling (DNA-MP) and fusion testing, on a cohort of 30 institutionally diagnosed METs from 29 patients. On histologic and immunophenotypic evaluation, 22 of 30 tumors diagnosed as MET fulfilled strict histologic and immunophenotypic criteria. Among those failing to meet criteria, most were reclassified as another tumor entity by DNA-MP. Seven tumors meeting criteria grouped with another sarcoma reference type by DNA-MP, with confirmation of the characteristic driver abnormality of that tumor in selected cases. The remaining tumors histologically “consistent” with METs (n = 15) formed a distinct epigenetic cluster, independent of other reference entities. Recurrent gene fusions were identified in 11 of 15 tumors in this epigenetically distinct group, including EWSR1::KLF15 (n = 4), EWSR1::PBX3 (n = 2), and EWSR1::POU5F1 (n = 1) rearrangements. Clinicopathologic correlation suggests that EWSR1::KLF15 tumors are enriched in pediatric patients with aggressive histology. Our work shows that at least a subset of METs falls within an epigenetically distinct but heterogenous group. Furthermore, DNA-MP provides a useful adjunct to other molecular testing to help distinguish METs from histologic mimics.
Transcriptional analysis of C. elegans fmos at different life stages and their roles in ageing
Authors: Said Mohamed , Ferrara Bill T. , Aprodu Andreea , Cabreiro Filipe , Thompson Elinor P. , Everett Jeremy 
Published: December 2024

AbstractFlavin-containing monooxygenases (FMOs) are present in most organisms including plants, fungi, bacteria, invertebrates and vertebrates, where they catalyse the oxidative metabolism of a range of xenobiotics and endogenous metabolites. FMOs have been associated with ageing and longevity in the mouse and in C. elegans. As all five FMOs of C. elegans share an evolutionary root with mouse and human FMO5, it was of interest to discover if effects on ageing and longevity persisted across the whole group. We therefore investigated the impact of fmo gene knockout (KO) in C. elegans. We found that fmo-1, fmo-3 and fmo-4 KO significantly extended C. elegans lifespan relative to wild type and, as previously reported, FMO-2 over-expression did likewise. The transcription levels of C. elegans fmo genes were determined throughout the life cycle (embryo, larva and adult) in wild type and in each mutant to discover if their expression was related to stages in ageing, and expression levels were compared to those in human and mouse. In wild type worms, fmo-1 and fmo-4 were the mostly highly transcribed genes (especially at the larval stage), whereas fmo-2 and fmo-3 were the least transcribed, at all stages. Notably, the knockout of fmo-4 led to a 17- to 30-fold up-regulation of fmo-2, along with significantly increased levels of the other fmos. This parallels recent findings in the long-lived C. elegans tald-1 mutant where fmo-2 was also significantly up-regulated and reinforces its importance in lifespan extension.
Hyperspectral imaging reveals that sapropelic mud therapy may improve local tissue oxygenation in elderly
Authors: Calin Mihaela Antonina , Manea Dragos , Parasca Sorin Viorel , Popescu Cristina , Ionescu Elena-Valentina , Munteanu Constantin 
Published: December 2024

Abstract
Sapropelic muds have been used for centuries to treat various illnesses, but their effects and mechanisms are still under research. In this study the effects of Techirghiol sapropelic mud on tissue oxygenation in elderly patients diagnosed with neuromuscular disorders were investigated using spatial and spectral information provided by hyperspectral imaging technique. A group of 38 elderly patients with neuromuscular disorders for which they received mud therapy was studied. Sapropelic mud was applied to the lumbar region of each patient for 30 min, directly on the skin in a thick layer, while a symmetrical area of ​​15 × 10 cm in the same region was covered with a medical patch to serve as the control area. The mud is typically heated to a temperature of 40–45 °C before application. Hyperspectral images were taken before, after the first day of therapy, and at day seven. Oxyhemoglobin and deoxyhemoglobin concentrations and oxygen saturation values were calculated from the hyperspectral images and compared to control areas. The results revealed that, in the treated area, the mean oxyhemoglobin concentration increased with + 0.2127 ± 0.1096 mol cm∕L, while deoxyhemoglobin concentration decreased by -0.0509 ± 0.0558 mol cm∕L. Local tissue oxygen saturation raised to over 98% in all patients. Lesser improvements were recorded for the control areas: oxyhemoglobin increased with + 0.1673 ± 0.1059 mol cm∕L, and deoxyhemoglobin decreased with − 0.0525 ± 0.0578 mol cm∕L. A good level of agreement was found between values of oxygen saturation measured with hyperspectral imaging method and the classical pulse oximetry method. Thus, improvement in local circulation was demonstrated after mud therapy. In conclusion, therapy with Techirghiol sapropelic mud improved local tissue oxygenation, hyperspectral imaging being a reliable and non-invasive tool for monitoring these changes.
Sea level rise threatens Florida’s insular vertebrate biodiversity
Authors: Koen Erin L. , Barichivich William J. , Braun de Torrez Elizabeth C. , Walls Susan C. 
Published: December 2024

Abstract
Islands are some of the most biodiverse places on earth, but they are also hotspots of biodiversity loss. The coastline of Florida, U.S.A., is surrounded by thousands of islands, many of which are home to species that occur nowhere else. A rapidly emerging threat to these low-lying islands is inundation as sea levels rise. The capacity of island-dwelling species to adapt to climate change and sea level rise may be limited because many species do not have the ability to shift their distribution off the island to track favorable conditions. We assessed the vulnerability of Florida’s islands to inundation from sea level rise and estimated the terrestrial biodiversity on Florida’s islands that could be lost. Our models predicted that by 2100, over 80% and up to 90% of Florida’s islands could be completely inundated from sea level rise, depending on the sea level rise projection (1.2 m or 2.2 m). Of the 85 mammalian, reptilian, and amphibian species on our subset list of Florida’s Species of Greatest Conservation Need, over half occur on Florida’s islands for at least part of their range, highlighting the importance of these islands for housing Florida’s rich biodiversity. Notably, at least 12 mammal species and 7 reptile species have their entire distribution on Florida’s islands, and this count is likely an underestimate. Projections of future sea level rise mean that these island-endemic species face the threat of extinction in the wild if their island habitat is submerged.
The size of myocardial infarction and peri-infarction edema are not major determinants of diastolic impairment after acute myocardial infarction
Authors: Sundqvist Martin G. , Verouhis Dinos , Sörensson Peder , Henareh Loghman , Persson Jonas , Saleh Nawzad , Settergren Magnus , Witt Nils , Böhm Felix , Pernow John , Tornvall Per , Ugander Martin 
Published: December 2024

Abstract
To study the relationship between myocardial infarction size (IS), myocardial edema, and diastolic dysfunction after acute myocardial infarction (MI) both in the acute phase, and in the development of diastolic dysfunction in the follow-up setting. A further purpose is to study diastolic function using a mechanistic model as well as conventional parameters. Patients underwent cardiovascular magnetic resonance (CMR) imaging and echocardiography including mechanistic analysis using the parameterized diastolic filling method within 4–7 days (acute) and 6 months after a first acute anterior MI (n = 74). Linear regression modeling of echocardiographic diastolic parameters using CMR IS with and without inclusion of the myocardium at risk (MAR) and model comparisons with likelihood ratio tests were performed. Diastolic parameters at 6 months follow-up were modelled using final IS. For most parameters there was no association with acute IS, except for deceleration time (R2 = 0.24, p < 0.001), left atrial volume index (R2 = 0.13, p = 0.01) and the mechanistic stiffness parameter (R2 = 0.21, p < 0.001). Adding MAR improved only the e′ model (adjusted R2 increase: 0.08, p = 0.02). At 6 months follow-up, final IS was only associated with viscoelastic energy loss (R2 = 0.22, p = 0.001). In acute MI, both IS and MAR are related to diastolic function but only to a limited extent. At 6 months after infarction, increasing IS is related to less viscoelastic energy loss, albeit also to a limited extent. The relationship between IS and diastolic dysfunction seems to be mediated by mechanisms beyond simply the spatial extent of ischemia or infarction.
Some results and questions on r-amenability
Authors: Blanco A. 
Published: December 2024

Abstract
The notion of an r-amenable Banach lattice algebra was introduced by M. Roelands as an order counterpart to the well-known notion of amenability for Banach algebras. In this note, we consider the implications of r-amenability for various classes of Banach lattice algebras, and in particular, the question of whether r-amenability implies amenability. We also pose some questions arising from this research.
Comparative analysis of accuracy and computational complexity across 21 swarm intelligence algorithms
Authors: Warnakulasooriya Kolitha , Segev Aviv 
Published: December 2024

Abstract
Nonlinear, complex optimization problems are prevalent in many scientific and engineering fields. Traditional algorithms often struggle with these problems due to their high dimensionality and intricate nature, making them time-consuming. Many researchers have proposed new metaheuristic algorithms inspired by biological behaviors in nature, which comparatively show higher performance and accuracy than traditional optimization algorithms. Nature-inspired algorithms, particularly those based on swarm intelligence, offer adaptable and efficient solutions to these challenges. In recent years, swarm intelligence algorithms have made significant advancements. Classical and CEC benchmark suits are immersively useful for studying the performance of optimization algorithms. According to our literature survey, we identified that many algorithms were evaluated based on accuracy. Currently, swarm intelligence algorithms are used in many applications, and efficiency and computational complexity need to be evaluated. A broad-level study of the computational complexity and accuracy of popular swarm intelligence algorithms has not been done recently. Therefore this study we comprehensively evaluate and compare 21 bio-inspired swarm intelligence algorithms on eight non-separable unimodal, eight separable unimodal, five non-separable multimodal, seven separable multimodal functions, and two CEC 2018 many objective functions. We study the structure and mathematical model of the selected algorithms. Then we categorized selected algorithms into six different behavioral groups. We calculated the root mean square error between expected and actual values. Then we performed an RMSE cross-validation statistical test to understand how accurately an algorithm resolves an average problem. We found that Artificial Lizard Search Optimization (ALSO) is the most prominent algorithm in accuracy and efficiency. Besides that, Cat Swarm Optimization (CSO), Squirrel Search Algorithm (SSA), and Chimp Optimization Algorithm (CHOA-B) are also considered more universal algorithms. The Squirrel Search Algorithm (SSA) is ALSO’s second-best algorithm in time complexity. Wasp Swarm Algorithm (WSO), and Bat-Inspired Algorithm (BA) presented the lowest time complexity. Finally, several important issues and research directions are discussed.