bluuebunny/crossref_metadata_2025_split huggingface dataset:
A gene for resistance to the Varroa mite (Acari) in honey bee (Apis mellifera) pupae
Authors: Conlon Benjamin H. , Aurori Adriana , Giurgiu Alexandru‐Ioan , Kefuss John , Dezmirean Daniel S. , Moritz Robin F. A. , Routtu Jarkko 
Published: March 2019

AbstractSocial insect colonies possess a range of defences which protect them against highly virulent parasites and colony collapse. The host–parasite interaction between honey bees (Apis mellifera) and the mite Varroa destructor is unusual, as honey bee colonies are relatively poorly defended against this parasite. The interaction has existed since the mid‐20th Century, when Varroa switched host to parasitize A. mellifera. The combination of a virulent parasite and relatively naïve host means that, without acaricides, honey bee colonies typically die within 3 years of Varroa infestation. A consequence of acaricide use has been a reduced selective pressure for the evolution of Varroa resistance in honey bee colonies. However, in the past 20 years, several natural‐selection‐based breeding programmes have resulted in the evolution of Varroa‐resistant populations. In these populations, the inhibition of Varroa's reproduction is a common trait. Using a high‐density genome‐wide association analysis in a Varroa‐resistant honey bee population, we identify an ecdysone‐induced gene significantly linked to resistance. Ecdysone both initiates metamorphosis in insects and reproduction in Varroa. Previously, using a less dense genetic map and a quantitative trait loci analysis, we have identified Ecdysone‐related genes at resistance loci in an independently evolved resistant population. Varroa cannot biosynthesize ecdysone but can acquire it from its diet. Using qPCR, we are able to link the expression of ecdysone‐linked resistance genes to Varroa's meals and reproduction. If Varroa co‐opts pupal compounds to initiate and time its own reproduction, mutations in the host's ecdysone pathway may represent a key selection tool for honey bee resistance and breeding.
Ethical and moral considerations of (patient) centredness in nursing and healthcare: Navigating uncharted waters
Authors: O'Rourke Deanne J. , Thompson Genevieve N. , McMillan Diana E. 
Published: March 2019

AbstractThis discussion paper aims to explore potential ethical and moral implications of (patient) centredness in nursing and healthcare. Healthcare is experiencing a philosophical shift from a perspective where the health professional is positioned as the expert to one that re‐centres care and service provision central to the needs and desires of the persons served. This centred approach to healthcare delivery has gained a moral authority as the right thing to do. However, little attention has been given to its moral and ethical theoretical grounding and potential implications for nurses, persons served and the healthcare system. Based upon a review of academic and grey literature, centredness is proposed as a value‐laden concept in nursing inquiry. Potential moral and ethical implications of centredness on nurses/healthcare providers, persons served and the healthcare system are discussed. These challenges are then considered within the context of normative and relational ethical theories. These perspectives may offer guidance relative to how one should act in those circumstances as well as an understanding as to how interdependency and engagement with the other person(s) can help navigate the challenges of a centred care approach. Viewing centredness through an ethical theoretical lens provides a valuable discourse to nursing in efforts to expand the knowledge base and integrate centred approaches into practice and policy.
Varying screen size for passive video distraction during induction of anesthesia in low‐risk children: A pilot randomized controlled trial
Authors: Rodriguez Samuel T. , Jang Olivia , Hernandez Jessica Maya , George Alexandria Joseph , Caruso Thomas J. , Simons Laura E. 
Published: March 2019

SummaryBackgroundPreoperative anxiety affects up to 65% of children who undergo anesthesia induction and often results in uncooperative behavior. Electronic devices have been used to distract children to reduce anxiety and create a more enjoyable preoperative experience. Few studies have compared the effects of different video delivery systems on preoperative anxiety.AimsThe primary aim was to determine if a large projection‐based video screen mounted to a patient's bed decreased anxiety when compared to a tablet during mask induction of anesthesia in children from 4‐10 years of age.MethodsWe performed a prospective, randomized trial to determine differences in our primary outcome, preoperative anxiety, between the large Bedside Entertainment and Relaxation Theater (BERT) and a smaller tablet screen. Secondary outcomes included (a) induction compliance; (b) child fear; (c) frequency of emergence delirium; and (d) satisfaction.ResultsIn examining the primary outcome for 52 patients, there was a main effect for time on mYPAS scores, f(2, 51) = 13.18, P < 0.01. mYPAS scores significantly increased across time for both groups. The interaction for time (T0, T1 or T2) × group (BERT vs Tablet) was not significant, f(2, 51) = 1.96, P = 0.15; thus changes in mYPAS scores across time did not differ by group status. There was no significant difference in induction compliance, child fear, emergence delirium, or satisfaction between the two groups.ConclusionIn a low‐risk population, preoperative anxiety was low and induction compliance was high when pairing screen‐based distraction interventions, regardless of size, with parental presence at induction of anesthesia.
Transplantation of adult‐size kidneys in small pediatric recipients: A single‐center experience
Authors: Muramatsu Masaki , Mizutani Toshihide , Hamasaki Yuko , Takahashi Yusuke , Itabashi Yoshihiro , Kubota Mai , Hashimoto Junya , Oguchi Hideyo , Sakurabayashi Kei , Hyodo Yoji , Shinoda Kazunobu , Kawamura Takeshi , Sakai Ken , Shishido Seiichiro 
Published: March 2019

AbstractRTx of adult‐size kidneys presents a size mismatch in small pediatric recipients, and there are potential surgical complications. This study reveals the outcomes of intra‐ and extraperitoneal RTx in low‐weight (less than 15 kg) pediatric recipients. We studied 51 pediatric patients weighing less than 15 kg who received a living‐related donor renal transplant between 2009 and 2017. The intraperitoneal (group A, n = 24) and extraperitoneal (group B, n = 27) approaches were compared. In group A, the mean age, Ht, and weight were 3.8 ± 1.6 years, 83.7 ± 6.5 cm, 10.5 ± 1.8 kg; in group B, 5.0 ± 1.9 years, 95.3 ± 7.3 cm, and 13.0 ± 1.4 kg. Single renal artery grafts (21 in group A and 16 in group B) and double renal artery grafts (three in group A and 11 in group B) were performed. Of the patients with double renal artery transplants, one in group A and six in group B underwent ex vivo arterial reconstruction. The eGFR (mL/min/1.73 m2) at 1‐week post‐transplant in group A was significantly higher than that in group B; the eGFRs at 4 weeks post‐transplant did not differ. One graft was lost in group B because of vascular thrombosis. Post‐transplant complications included ileus and transplant ureteral stenosis. There was no significant difference in 5‐year graft survival rate (group A 100%, group B 91.7%). Both transplant approaches are feasible to adapt to a size mismatch between the adult‐size donor kidney and low‐weight pediatric recipients.
Voters’ Partisan Responses to Politicians’ Immoral Behavior
Authors: Walter Annemarie S. , Redlawsk David P. 
Published: March 2019

Politicians’ moral behaviors affect how voters evaluate them. But existing empirical research on the effects of politicians’ violations of moral standards pays little attention to the heterogeneous moral foundations of voters in assessing responses to violations. It also pays little attention to the ways partisan preferences shape responses. We examine voters’ heterogeneous evaluative and emotional responses to presumably immoral behaviors by politicians. We make use of moral foundation theory’s argument that people vary in the extent to which they endorse, value, and use the five universally available moral intuitions: care, fairness, loyalty, authority and sanctity. We report on a 5 × 3 between‐subjects experiment asking a random sample of 2,026 U.S. respondents to respond to politicians’ violations of different moral foundations. We randomly vary which of the five foundations is violated and the partisanship of the actor (Republic/Democrat/Nonpartisan). Results suggest that partisanship rather than moral foundations drives most of U.S. voters’ responses to moral foundations violations by politicians. These foundations seem malleable when partisan actors are involved. While Democrats in this sample show stronger negative emotional response to moral violations than Republicans, partisans of both parties express significantly greater negativity when a politician of the other party violates a moral foundation.
A combination of mupirocin and acidic fibroblast growth factor for nipple fissure and nipple pain in breastfeeding women: protocol for a randomised, double-blind, controlled trial
Authors: Lv Xiaofang , Feng Rui , Zhai Jingbo 
Published: March 2019

IntroductionNipple fissure and nipple pain are common complaints among breastfeeding mothers. Studies found that mupirocin was effective in preventing and treating infections of damaged nipple and nipple pain. Acidic fibroblast growth factor (aFGF) plays an important role in wound healing. However, current evidence on the efficacy and safety of mupirocin plus aFGF for nipple fissure and nipple pain in breastfeeding women is inconclusive due to the lack of well-designed randomised controlled trials on this topic. The purpose of this study is to test the hypothesis that mupirocin plus aFGF is more effective than mupirocin alone for nipple fissure and nipple pain in breastfeeding women.Methods and analysisThis study is a randomised, double-blind, single-centre, parallel-group clinical trial. A total of 120 breastfeeding women with nipple fissure and nipple pain will be randomly assigned to either mupirocin plus aFGF group or mupirocin plus placebo group according to a computer-generated random allocation sequence. The treatment period lasts 14 days. The primary outcome is nipple pain intensity measured by the Visual Analogue Scale on day 14 during the treatment period. Secondary outcome measures include time to complete nipple pain relief, changes in the Nipple Trauma Score, time to complete healing of nipple trauma, quality of life measured by the Maternal Postpartum Quality of Life (MAPP-QOL) Questionnaire, the frequency of breast feeding, the rate of breastfeeding discontinuation, weight change in infants and adverse events.Ethics and disseminationThe study has gained approval from the Ethics Review Committee of Tianjin Central Hospital of Gynaecology Obstetrics on 22 January 2018 (approval no. 2018KY001). We plan to publish our research findings in a peer-reviewed academic journal and disseminate these findings in international conferences. This study has been registered with the Chinese Clinical Trial Registry.Trial registration numberChiCTR1800017248.
How does returning to work after retirement influence older workers’ health? A scoping review protocol
Authors: Lecours Alexandra , Lord Marie-Michèle , Negrini Alessia , Robitaille Rosalie 
Published: March 2019

IntroductionThe return to the labour market after retirement is an increasing phenomenon in the North American population. It is the subject of a growing number of studies, whose conclusions seem inconsistent. As returning to working life after retirement is not neutral for individuals, the aim of this article is to present the protocol of a scoping review about its effects on older workers’ health.Methods and analysisThe methodology of Arksey and O’Malley, including the recommendations of Levacet aland Daudtet alwill be used. The process is composed of seven steps, from the identification of the research question, to the planning of knowledge transfer activities. Documents dealing with retirees returning to work in connection with health will be explored and analysed using the International Classification of Functioning, Disability and Health.Ethics and disseminationApproval has been obtained for the consultation step of the protocol (ethics board of the Centre intégré universitaire en santé et servicessociaux de la Capitale Nationale, project #2019-1753). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols checklist will be used to support transparency and guide translation of findings. Findings will be shared with various stakeholders involved in older workers’ health. Findings will also be disseminated in workshops, peer-reviewed journals and conferences.
A Novel On-Chip Task Scheduler for Mixed-Criticality Real-Time Systems
Authors: Kohútka Lukáš , Nagy Lukáš , Stopjaková Viera 
Published: March 2019

This paper presents a novel design of a coprocessor that performs hardware-accelerated task scheduling for embedded real-time systems consisting of mixed-criticality real-time tasks. The proposed solution is based on the Robust Earliest Deadline (RED) algorithm and previously developed hardware architectures used for scheduling of real-time tasks. Thanks to the HW implementation of the scheduler in the form of a coprocessor, the scheduler operations (i.e., instructions) are always completed in two clock cycles regardless of the actual or even maximum task amount within the system. The proposed scheduler was verified using simplified version of UVM and applying billions of randomly generated instructions as inputs to the scheduler. Chip area costs are evaluated by synthesis for Intel FPGA Cyclone V and for 28-nm TSMC ASIC. Three versions of real-time task schedulers were compared: EDF-based scheduler designed for hard real-time tasks only, GED-based scheduler and the proposed RED-based scheduler, which is suitable for tasks of various criticalities. According to the synthesis results, the RED-based scheduler consumes LUTs and occupies larger chip area than the original EDF-based scheduler with equivalent parameters used. However, the RED-based scheduler handles variations of task execution times better, achieves higher CPU utilization and can be used for the scheduling of hard real-time, soft real-time and nonreal-time tasks combined in one system, which is not possible with the former algorithms.
Potential Benefits of Nitrate Supplementation on Antioxidant Defense System and Blood Pressure Responses after Exercise Performance
Authors: Menezes Eduardo F. , Peixoto Leonardo G. , Teixeira Renata R. , Justino Allisson B. , Puga Guilherme M. , Espindola Foued S. 
Published: March 2019

Nitrate (NO3−) supplementation is associated with exercise performance, oxygen uptake, blood flow, and blood pressure improvement, and it can act as an antioxidant agent. This study evaluated the effects of sodium nitrate supplementation on oxidative stress markers and blood pressure responses after aerobic exercise performance in physically active males. Fourteen subjects aged 22±3 years and with a BMI of 23±1 kg/m2 were submitted to four exercise tests in intervals of 5 days. Nitrate supplementation (NO session) and placebo supplementation (PL session) were acute (AC) and over a period of 5 days (FD) in random order with a crossover design. Saliva was collected at basal (0′); 60 min after supplementation (60′); immediately after exercise (90′); and 15, 30, and 60 min after the test (105′, 120′, and 150′). The NO session had higher concentrations (P<0.05) of salivary nitrite in both AC and FD treatments when compared with the PL session. There was a reduction in systolic blood pressure (SBP) only after FD in the NO session. Furthermore, uric acid and total antioxidant capacity (FRAP) salivary concentrations increased, while SOD activity and TBARS levels decreased after FD but not after AC in the NO session. The results suggest that nitrate supplemented over a period of 5 days reduced SBP and indirectly acted as an antioxidant in healthy nonsedentary young men.
Diagnostic Yield of Colon Capsule Endoscopy in Detection of Superficial Colorectal Lesions
Authors: Otani Ichiro , Oka Shiro , Tanaka Shinji , Iio Sumio , Tsuboi Akiyoshi , Kunihara Sayoko , Hiyama Yuichi , Chayama Kazuaki 
Published: March 2019

Background: The efficacy of second-generation PillCam ­COLON2 capsule endoscopy (CCE2) in detecting colorectal superficial lesions remains unclear. Objective: We sought to determine the diagnostic yield of CCE2 in the detection of colorectal superficial lesions. Methods: We performed CCE2 in 60 consecutive patients between April 2011 and ­December 2017. Lesions ≥6 mm in size were detected in 34 patients (25 males, average age: 60.5 years). We performed endoscopic resection and histopathological analysis of all resected lesions within 3 months after CCE2. We considered the optical colonoscopy (OC) findings as the gold standard and evaluated CCE2 sensitivity. Results: Sixty-seven lesions (≥6 mm) were detected via OC, with 27 colorectal superficial lesions and 40 protruded lesions. CCE2 sensitivity for ≥6-mm-sized, superficial, and protruded lesions was 84, 78, and 88%, respectively. No significant intergroup differences were observed. CCE2 false-negative colorectal superficial lesions accounted for 31% of right-sided colon lesions and 50% of sessile serrated adenomas/polyps (SSA/Ps). The CCE2 false-negative protruded lesions accounted for 17% of right-sided colon lesions. Conclusion: CCE2 sensitivities for colorectal superficial and protruded lesions were not significantly different. However, flat-type SSA/Ps in the right colon, especially when the transit time is fast, have a risk of demonstrating CCE2 false-negative results.
Aristotle on Musical Catharsis and the Pleasure of a Good Story
Authors: Ferrari G. R. F. 
Published: March 2019

AbstractThe pleasure attending dramatic catharsis, according to Aristotle, is a pleasure the audience feels when the tension that has been developing throughout the action of the play is released. Catharsis does not edify or improve us, whether morally or intellectually: it is an aesthetic satisfaction. Crucial to the argument is a new interpretation of Politics 8.7, where musical catharsis is taken to belong, not to the realm of ‘entertainment’, παιδιά, but to that of ‘leisurely activity’, διαγωγή. By this classification, the pleasure attending musical catharsis, too, is shown to be an aesthetic satisfaction, corresponding in this respect to dramatic catharsis.
A natural orchestra: how are anuran choruses formed in artificial ponds in southeast Brazil?
Authors: Duarte Marina H.L. , Caliari Ernesto P. , Viana Yasmin P. , Nascimento Luciana B. 
Published: March 2019

Abstract
Choruses are commonly observed phenomena in both terrestrial and aquatic environments and are the product of species vocalizing contemporaneously usually at dawn and dusk. This study analyzes the composition and temporal distribution of anuran choruses at a recently built artificial pond in Southeast Brazil. Data were collected using Passive Acoustic Monitoring devices set to record 24-hours per day, seven days a month, throughout an entire year (October 2016 to September 2017). A total of eight species participated in the studied choruses: Boana albopunctata, Boana faber, Boana lundii, Phyllomedusa burmeisteri, Physalaemus cuvieri, Rhinella ornata, Rhinella diptycha and Scinax aff. perereca. The number of species, call emission rate, temperature, and humidity were all higher before midnight and during the rainy season. The species differed significantly in mean call rate by hour at which they sang. Boana faber and B. albopunctata were the species with the greatest vocal activity in both seasons, and were predominantly responsible for initiating choruses in the rainy season, while R. diptycha and B. lundii initiated choruses in the dry season. Anuran choruses started around 18:30 h during the rainy season and varied according to the time of sunset, while they started later in the dry season and were not correlated with sunset time. There was a positive correlation between the number of species calling and the call emission rate per month in both seasons. The results show that the choruses were correlated with climatic factors and that the species distributed their vocalizations over time, thus reducing acoustic overlap.
Epistemology–Ontology Relations in Social Research: A Review
Authors: Ejnavarzala Haribabu 
Published: March 2019

Ananta Kumar Giri (Ed.), Pathways of Creative Research: Towards a Festival of Dialogues. New Delhi: Primus Books, 2017, 485 pp., ₹1,395 (hardback). ISBN: 978-93-84082-05-5. Ananta Kumar Giri (Ed.), Cultivating Pathways of Creative Research: New Horizons of Transformative Practice and collaborative Imagination. New Delhi: Primus Books, 2017, 517 pp., ₹1,495 (hardback). ISBN: 978-93-86552-19-8. Ananta Kumar Giri (Ed.), Research as Realization: Science, Spirituality and Harmony. New Delhi: Primus Books, 2017, 351 pp., ₹1,195 (hardback). ISBN: 978-93-86552-15-0.
Using the System of Least Prompts to Teach Personal Hygiene Skills to a High School Student with Comorbid Visual Impairment and Autism Spectrum Disorder
Authors: Probst Kristi M. , Walker Virginia L. 
Published: March 2019

Introduction This study evaluated the effectiveness of a workshop and follow-up coaching sessions on the implementation of the system of least prompts procedure by classroom team members and explored whether this intervention resulted in personal hygiene skill acquisition by a male high school student with comorbid visual impairment and autism spectrum disorder. Methods Implementation fidelity data were analyzed descriptively through visual analysis. A multiple baseline design across behaviors was utilized to evaluate the effectiveness of the system of least prompts procedure on student skill acquisition. Results Implementation fidelity was high and increased over the course of the study: paraeducator 1: 93.9% (range, 70 to 100%); paraeducator 2: 78.2% (range, 11 to 90%); and special education teacher: 94.1% (range, 35 to 100%). In addition, the student's independent performance improved from baseline to intervention across each targeted skill, with Tau -U scores as follows: cleaning the augmentative and alternative communication device: 0.78; washing hands: 0.76; and brushing teeth: 0.92. Classroom team members found both the training procedures and the system of least prompts intervention to be of value and effective. Discussion During intervention, classroom team members implemented the system of least prompts with fidelity and the student mastered each skill. These results are promising and add to the significantly limited literature on instructional interventions for students with comorbid visual impairment and autism spectrum disorder. Implications for practitioners Classroom team members can effectively be taught to use the system of least prompts with students with comorbid visual impairment and autism spectrum disorder. Furthermore, the intervention might be used to increase independent functioning for students with these comorbid conditions.