bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN TATA CARA PENCABUTAN PENGUKUHAN PKP SESUAI PERATURAN DIITJEN PAJAK NOMOR 12 TAHUN 2014 PADA KPP PRATAMA MANADO
Authors: Mangare Virgie 
Published: August 2018

Tax is playing important role in economy of the country. Today, number of firms from big to small many have not been listed to KPP Pratama Manado. Directorate General of Taxation Issues rule No.12 Tahun 2014 in order to grouping the sales limit and simplified the administration and controlling. Many business sector listed but have not been revocation and have sales under Rp. 4,8 Billion. The purpose if this research is to knowing that the application of rules Directorate General of Taxation No.12 Tahun 2014. Data analysis method uses is descriptive. To know the limit of the sales it need income statement. Tax fare and calculation method of income tax. The difference of tax which is deposited is quite large. The application of PP No.46 Tahun 2013 is really profitable because income tax which must be deposited is much smaller. Meaning the new rules is much simpler, and to make the government more easier to grouping the sales limit and the revocation of taxable enterprise. To improve service and improve administratif simplification as well as controling. KPP Pratama Manado should be more sosializing the new regulations.
Weak-lensing Power Spectrum Reconstruction by Counting Galaxies. II. Improving the ABS Method with the Shift Parameter
Authors: Zhang Pengjie , Yang Xinjuan , Zhang Jun , Yu Yu 
Published: August 2018

Abstract
In Paper I of this series, we proposed an analytical method of blind separation (ABS) to extract the cosmic magnification signal in galaxy number distribution and reconstruct the weak-lensing power spectrum. Here, we report a new version of the ABS method with significantly improved performance. This version is characterized by a shift parameter,

, with the special case of

corresponding to the original ABS method. We have tested this new version, compared it with the previous one, and confirmed its superior performance in all investigated situations. Therefore, it supercedes the previous version. The proof of concept studies presented in this paper demonstrate that it may enable surveys such as LSST and SKA to reconstruct the lensing power spectrum at z ≃ 1 with 1% accuracy. We will test the new ABS method in more realistic simulations to verify its applicability to real data.
Limits on the Contribution of Endogenic Radiolysis to the Presence of Molecular Oxygen in Comet 67P/Churyumov–Gerasimenko
Authors: Bouquet Alexis , Mousis Olivier , Teolis Benjamin , Nicolaou Georgios , Ozgurel Ozge , Pauzat Francoise , Ellinger Yves , Ronnet Thomas , Waite J. Hunter 
Published: August 2018

Abstract
Radiolytic production has been proposed as a potential source for the molecular oxygen observed in comet 67P/Churyumov–Gerasimenko. Radiolysis can be exogenic or endogenic, the latter due to radionuclides present in the dust constitutive of the comet nucleus. We investigated the possibility of forming a significant amount of molecular oxygen through endogenic radiolysis. We applied a model of radiolytic production, developed for an Earth rock–water mixture, and improved it to account for the effect of the size of a radionuclide-bearing grain on the net radiation deposited in its ice mantle. We calculated the possible production of molecular oxygen considering the available experimental values of radiolytic yields. We found that endogenic radiolysis cannot account for the totality of the 3.8% (relative to water) O2 abundance derived from the ROSINA observations, with an end member case of our model producing at most a 1% abundance. By contrast, we predict H2O2 production leads to an abundance up to two orders of magnitude above observed values.
Active Galactic Nucleus Feedback in an Elliptical Galaxy with the Most Updated AGN Physics. II. High Angular Momentum Case
Authors: Yoon Doosoo , Yuan Feng , Gan Zhao-Ming , Ostriker Jeremiah P. , Li Ya-Ping , Ciotti Luca 
Published: August 2018

Abstract
This is the second paper of our series of works of studying the effects of active galactic nuclei (AGNs) feedback on the cosmological evolution of an isolated elliptical galaxy by performing two-dimensional hydrodynamical simulations. Compared to previous works, the main improvement here is that we adopt the most up-to-date AGN physics, which is described in detail in the first paper, including the discrimination of the two accretion modes and the most up-to-date descriptions of the wind and radiation in the two modes. In Paper I, we consider the case that the specific angular momentum of the gas in the galaxy is very low. In this paper, we consider the case that the specific angular momentum of the gas is high. At the galactic scale, we adopt the gravitational torques raised due to non-axisymmetric structure in the galaxy as the mechanism of the transfer of angular momentum of gas, as proposed in some recent works. Because our simulations are axisymmetric, we make use of a parameterized prescription to mimic this mechanism. Special attention is paid to the effects of specific angular momentum of the galaxy on the AGN light curve, growth of the black hole mass, AGN duty-cycle, star formation, and the X-ray surface brightness. We find that some results are qualitatively similar to those shown in Paper I, while other results, such as star formation and black hole growth, show a significant difference due to the mass concentration in the galactic disk as a consequence of galactic rotation.
Determining the Kappa Distributions of Space Plasmas from Observations in a Limited Energy Range
Authors: Nicolaou G. , Livadiotis G. , Owen C. J. , Verscharen D. , Wicks R. T. 
Published: August 2018

Abstract
Spacecraft observations allow us to reconstruct the velocity distributions of space plasmas, which fully describe the kinetic state of the plasma. Space plasmas often exist in stationary states out of equilibrium, which are typically described by kappa distributions. Thus, the kappa index and temperature that govern these distributions are parameters that need to be determined for a full and accurate description of these plasmas. In this study, we demonstrate a novel and reliable way to determine the kappa index and temperature of plasma distribution functions constructed from counts observed in a narrow energy range by typical electrostatic sensors. Our method applies to cases in which the high-energy tail of the plasma is observed with significant uncertainty, or not observed at all. For the validation of our method, we produce pseudo-observations for typical input plasma parameters, specifically considering the design of the ion plasma instrument SWA-PAS on board the Solar Orbiter mission. Our method reliably estimates the relevant plasma parameters by fitting the angular spread of the distribution in a narrow energy range around the core bulk energy. We compare the output of our technique with the input parameters used to generate artificial data for a selected range of the kappa index and the temperature, and for a bulk energy typical for the solar wind. In addition, we study the effects of Poisson errors on the instrument’s counting statistics, test our method against Helios 2 measurements, and discuss its potential applications and limitations.
Après la pluie, une éclaircie ? L’enfant orphelin confronté à la recomposition familiale en littérature jeunesse
Authors: Mietkiewicz Marie-Claude , Lemoine Lise , Schneider Benoît 
Published: August 2018

Dans le cadre d’une recherche sur la littérature jeunesse dans l’accompagnement de l’enfant orphelin, ce travail porte sur les livres dans lesquels la recomposition familiale est abordée. En l’absence irréversible du parent décédé, la recomposition familiale confronte l’enfant orphelin à une nouvelle rupture dans la trajectoire familiale et oblige à penser la place du nouveau partenaire sans mettre en péril la pérennité du lien avec le parent définitivement manquant. Vingt-deux livres, destinés à des enfants de 3 à 11 ans, publiés en langue française au xxi e siècle, rendent compte des interrogations des jeunes héros, du rejet initial de l’intrus à l’acceptation conditionnelle. Miroir, mais aussi filtre, la littérature jeunesse semble être un médiateur capable d’aider l’enfant orphelin lors de l’entrée en scène d’un peut-être (futur) beau-parent.
Effect of pitfall trap depth on epigaeic beetle sampling (Coleoptera: Carabidae and Staphylinidae) in wet forested ecosites in Alberta, Canada
Authors: Hammond H.E. James , Langor David W. , Hartley Dustin J. 
Published: August 2018

AbstractThe depth at which pitfall traps were sunk into the ground and the resulting catches of epigaeic Carabidae (Coleoptera) and Staphylinidae (Coleoptera) assemblages in subhygric to hydric ecosites with very deep organic soil layers was investigated in the upper foothills ecoregion of Alberta, Canada. Traps were installed at seven sites, with six surface traps (the pitfall trap lip <5 cm below soil surface) and six deep traps (the pitfall trap lip >20 cm below soil surface) at each site. A total of 5289 beetles representing 75 taxa were collected. There were no significant effects of trap depth on catch. Rarefaction estimates of species diversity were higher in surface pitfall traps for both taxa. The similarity of pooled catches between deep and surface traps was on average 75%, suggesting that both trap types were collecting similar faunas. We found no advantage to using deep pitfall traps in addition to surface traps to sample the epigaeic fauna of wet forest stands and peatlands.
PPARγ Deficiency Suppresses the Release of IL-1β and IL-1α in Macrophages via a Type 1 IFN–Dependent Mechanism
Authors: Weber Kassandra J. , Sauer Madeline , He Li , Tycksen Eric , Kalugotla Gowri , Razani Babak , Schilling Joel D. 
Published: August 2018

Abstract
Obesity and diabetes modulate macrophage activation, often leading to prolonged inflammation and dysfunctional tissue repair. Increasing evidence suggests that the NLRP3 inflammasome plays an important role in obesity-associated inflammation. We have previously shown that activation of the lipotoxic inflammasome by excess fatty acids in macrophages occurs via a lysosome-dependent pathway. However, the mechanisms that link cellular lipid metabolism to altered inflammation remain poorly understood. PPARγ is a nuclear receptor transcription factor expressed by macrophages that is known to alter lipid handling, mitochondrial function, and inflammatory cytokine expression. To undercover novel links between metabolic signaling and lipotoxic inflammasome activation, we investigated mouse primary macrophages deficient in PPARγ. Contrary to our expectation, PPARγ knockout (KO) macrophages released significantly less IL-1β and IL-1α in response to lipotoxic stimulation. The suppression occurred at the transcriptional level and was apparent for multiple activators of the NLRP3 inflammasome. RNA sequencing revealed upregulation of IFN-β in activated PPARγKO macrophages, and this was confirmed at the protein level. A blocking Ab against the type 1 IFNR restored the release of IL-1β to wild type levels in PPARγKO cells, confirming the mechanistic link between these events. Conversely, PPARγ activation with rosiglitazone selectively suppressed IFN-β expression in activated macrophages. Loss of PPARγ also resulted in diminished expression of genes involved in sterol biosynthesis, a pathway known to influence IFN production. Together, these findings demonstrate a cross-talk pathway that influences the interplay between metabolism and inflammation in macrophages.
Collateral Damage: What Effect Does Anti-CD4 and Anti-CD8α Antibody–Mediated Depletion Have on Leukocyte Populations?
Authors: Jung So Ri , Suprunenko Tamara , Ashhurst Thomas M. , King Nicholas J. C. , Hofer Markus J. 
Published: August 2018

Abstract
Anti-CD4 or anti-CD8α Ab–mediated depletion strategies are widely used to determine the role of T cell subsets. However, surface expression of CD4 and CD8α is not limited to T cells and occurs on other leukocyte populations as well. Using both unbiased t-distributed stochastic neighbor embedding of flow cytometry data and conventional gating strategies, we assessed the impact of anti-CD4 and anti-CD8α Ab–mediated depletion on non–T cell populations in mice. Our results show that anti-CD4 and anti-CD8α Ab injections not only resulted in depletion of T cells but also led to depletion of specific dendritic cell subsets in a dose-dependent manner. Importantly, the extent of this effect varied between mock- and virus-infected mice. We also demonstrate the importance of using a second, noncompeting Ab (clone CT-CD8α) to detect CD8α+ cells following depletion with anti-CD8α Ab clone 2.43. Our study provides a necessary caution to carefully consider the effects on nontarget cells when using Ab injections for leukocyte depletion in all experimental conditions.
Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation inIGHDHaploinsufficient Humans
Authors: Nechvatalova Jana , Bartol Sophinus J. W. , Chovancova Zita , Boon Louis , Vlkova Marcela , van Zelm Menno C. 
Published: August 2018

AbstractSurface IgD is coexpressed with IgM on naive mature B cells. Still, the role of surface IgD remains enigmatic even 50 y after its initial discovery. In this study, we examined the in vivo role of surface IgD in human B cell homeostasis and Ab responses in four individuals with heterozygous nonsense mutations in IGHD. All IGHD heterozygous individuals had normal numbers of B cells and serum Igs and did not show signs of immunodeficiency or immune dysregulation. IgD+ and IgD− naive mature B cells were present in equal numbers and showed similar immunophenotypes, except for decreased expression of CD79b in the IgD− subset. Furthermore, both IgD+ and IgD− naive mature B cells had normal replication histories and similar capacities to differentiate into plasma cells upon in vitro stimulation, and Ig class–switched memory B cells showed similar levels of somatic hypermutations. Thus, human B cells lacking IgD expression develop normally and generate immunological memory in vivo, suggesting that surface IgD might function more restrictedly in regulating of B cell activation to specific antigenic structures.
Effectiveness of ammonia reduction on control of fine particle nitrate
Authors: Guo Hongyu , Otjes Rene , Schlag Patrick , Kiendler-Scharr Astrid , Nenes Athanasios , Weber Rodney J. 
Published: August 2018

Abstract. In some regions, reducing aerosol ammonium nitrate
(NH4NO3) concentrations may substantially improve air quality.
This can be accomplished by reductions in precursor emissions, such as
nitrogen oxides (NOx) to lower nitric acid (HNO3)
that partitions to the aerosol, or reductions in ammonia (NH3) to
lower particle pH and keep HNO3 in the gas phase. Using the
ISORROPIA-II thermodynamic aerosol model and detailed observational data sets,
we explore the sensitivity of aerosol NH4NO3 to gas-phase
NH3 and NOx controls for a number of contrasting
locations, including Europe, the United States, and China. NOx control
is always effective, whereas the aerosol response to NH3 control is
highly nonlinear and only becomes effective at a thermodynamic sweet
spot. The analysis provides a conceptual framework and fundamental
evaluation on the relative value of NOx versus NH3
control and demonstrates the relevance of pH as an air quality parameter. We
find that, regardless of the locations examined, it is only when ambient
particle pH drops below an approximate critical value of 3 (slightly higher
in warm and slightly lower in cold seasons) that NH3 reduction
leads to an effective response in PM2.5 mass. The required amount of
NH3 reduction to reach the critical pH and efficiently decrease
NH4NO3 at different sites is assessed. Owing to the linkage
between NH3 emissions and agricultural productivity, the substantial
NH3 reduction required in some locations may not be feasible.
Finally, controlling NH3 emissions to increase aerosol acidity and
evaporate NH4NO3 will have other effects, beyond reduction of
PM2.5 NH4NO3, such as increasing aerosol toxicity and
potentially altering the deposition patterns of nitrogen and trace nutrients.
Ensemble variational assimilation as a probabilistic estimator – Part 1: The linear and weak non-linear case
Authors: Jardak Mohamed , Talagrand Olivier 
Published: August 2018

Abstract. Data assimilation is considered as a problem in Bayesian estimation, viz. determine the probability distribution for the state of the observed system, conditioned by the available data. In the linear and additive Gaussian case, a Monte Carlo sample of the Bayesian probability distribution (which is Gaussian and known explicitly) can be obtained by a simple procedure: perturb the data according to the probability distribution of their own errors, and perform an assimilation on the perturbed data. The performance of that approach, called here ensemble variational assimilation (EnsVAR), also known as ensemble of data assimilations (EDA), is studied in this two-part paper on the non-linear low-dimensional Lorenz-96 chaotic system, with the assimilation being performed by the standard variational procedure. In this first part, EnsVAR is implemented first, for reference, in a linear and Gaussian case, and then in a weakly non-linear case (assimilation over 5 days of the system). The performances of the algorithm, considered either as a probabilistic or a deterministic estimator, are very similar in the two cases. Additional comparison shows that the performance of EnsVAR is better, both in the assimilation and forecast phases, than that of standard algorithms for the ensemble Kalman filter (EnKF) and particle filter (PF), although at a higher cost. Globally similar results are obtained with the Kuramoto–Sivashinsky (K–S) equation.
A new prognostic model using the NCCN-IPI and neutrophil-to-lymphocyte ratio in diffuse large B-cell lymphoma
Authors: Go Se-Il , Park Sungwoo , Kim Jung Hoon , Kim Hye Ree , Kim Minyoung , Moon Kyunglan , Seo Jangho , Lee Gyeong-Won 
Published: August 2018

Background: The neutrophil-to-lymphocyte ratio (NLR) has been known to predict the prognosis in diffuse large B-cell lymphoma (DLBCL). We planned to design a new prognostic model in DLBCL using well-known prognostic index and NLR. Methods: The data of 232 DLBCL patients treated with first-line R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) from 2004 to 2017 were retrospectively reviewed. Patients with NLR ≥6 and <6 were determined as the high and low NLR groups, respectively. Treatment response and survival were compared according to NLR status. Nomograms for predicting 5-year progression-free survival (PFS) and overall survival (OS) rates were constructed using NLR and other prognostic factors based on the National Comprehensive Cancer Network-International Prognostic Index (NCCN-IPI) NCCN-IPI. Results: The high NLR group had a low complete response (CR) rate compared to low NLR group (51.6% vs. 83.5%; p<0.001). The 5-year PFS and OS rates were 27.4% and 30% in the high NLR group and 61.1% and 63.7% in the low NLR group, respectively (both p<0.001). Multivariate analyses confirmed that NLR is one of the independent risk factors for failure to achieve CR and for worse PFS and OS. The nomogram showed superior discrimination ability for predicting 5-year PFS and OS rates compared with NCCN-IPI (c index 0.78 vs. 0.75 and 0.79 vs. 0.75, respectively). Conclusions: High NLR was associated with poor treatment response and worse PFS and OS in DLBCL. The nomogram developed from NCCN-IPI-based variables and NLR may help the clinicians to predict the prognosis individually in DLBCL patients, although it needs to be validated in the independent cohort.
Stable knockdown of ZBTB7A promotes cell proliferation and progression in nasopharyngeal carcinoma
Authors: Liu Fei , Tang Fengzhu , Lan Jiao , Jiao Wei , Si Yongfeng , Lu Wensheng , Mo Mingzheng , Li Bing , Lu Jinlong , Wei Jiazhang , Qin Ying , Xiao Ruiping , Zhang Benjian , Wang Yongli , Xiong Weiming 
Published: August 2018

Aims: Although high expression of ZBTB7A is positively relative to metastasis in nasopharyngeal carcinoma (NPC) patients, the association between its low expression and metastasis of NPC remains unclear. The present study aimed to definitely identify the association. Methods: The level of ZBTB7A was effectively knocked down by stable transfection of short hair RNA plasmid in NPC cell lines CNE2 and 5-8F (shRNA-CNE2 and shRNA-5-8F), compared with the cells that stably transfected empty plasmid (NC-CNE2 and NC-5-8F). The levels of ZBTB7A were assessed by real-time polymerase chain reaction and Western blot in the cell lines. MTT assay, colorimetric focus-formation assay, flow cytometry, wound healing assay, transwell assays, and xenograft model were performed to analyze cell vitality, proliferation, cell cycle, migration, invasion, and tumorigenicity. Results: The levels of ZBTB7A were effectively reduced in shRNA-CNE2 and shRNA-5-8F. Their carcinogenicity was stronger separately than the abilities of NC-CNE2 and NC-5-8F. NC-CNE2 and shRNA-CNE2 were selected to establish the xenograft model because of their stronger tumorigenicity than NC-6-10B and shRNA-5-8F. The assay showed that shRNA-CNE2 had stronger tumorigenicity than NC-CNE2. Conclusions: The results demonstrated the reverse association between the expression of ZBTB7A and the tumorigenicity of NPC. We postulate that some oncogenic pathways, which are suppressed by ZBTB7A, will vicariously promote the proliferation and progression of NPC when ZBTB7A is decreased.
Incidence rates of brain cancer following an outbreak of Chronic Fatigue Syndrome
Authors: Lin Cheng-Te Major , Younes Naji , Levine Paul H. 
Published: August 2018

Previous studies utilizing data from the Nevada Cancer Registry suggested a transient increase in non-Hodgkin’s lymphoma (NHL) and brain cancer in northern Nevada following an outbreak of Chronic Fatigue Syndrome (CFS) in that area which was not seen in southern Nevada which had no reported CFS outbreaks. A subsequent study from the National Cancer Institute (NCI) using data from the NCI’s Surveillance, Epidemiology and End Results (SEER) Program and Medicare documented the association between CFS and NHL on a national basis but no other cancer association was seen. Since brain cancer has a younger age distribution than NHL, we returned to the Nevada Cancer Registry and used ten more years of data and additional analyses to determine if there was an association between CFS and brain cancer by age. This study confirmed the increased incidence of brain cancer following the outbreak in northern Nevada but not southern Nevada with the increase limited to the under 65 age group, thus explaining why the SEER-Medicare analysis only analyzing data in the 65 and above age group did not detect this association.