bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meeting the Need: Developing Certification for Advanced Water Treatment Operators
Authors: Garner Steven 
Published: September 2019

Key TakeawaysThe California–Nevada Section of AWWA and California Water Environment Association sought a new industry certification for operators working with advanced water treatment (AWT) processes.A diverse set of stakeholders and experts added their perspectives on the development of the new certification.The AWTO Grade 3 exam was released in July 2019.
Phosphorylated Hsp27 prevents LPS‐induced excessive inflammation in THP‐1 cells via suppressing ROS‐mediated upregulation of CBP
Authors: Bi Xiaowen , Jiang Baolin , Zhou Jinyi , Luo Lan , Yin Zhimin 
Published: September 2019

AbstractHeat shock protein 27 (Hsp27) is a member of the small heat shock protein family expressed at high levels to protect cells against heat shock and other conditions of stress. Hsp27 has been indicated in the regulation of inflammation signaling pathway, and Hsp27 phosphorylation is vital for efficient control of host‐defense response in early stages of lipopolysaccharide (LPS)‐stimulated inflammation. The notion that CREB‐binding protein (CBP) is involved in the regulation of two major transcription factors, nuclear factor‐κB (NF‐κB) and AP‐1, suggests that CBP, as a coactivator protein, may also play an important role in the cellular response to inflammation. Here, we explored the mechanism underlying the regulatory relationships between Hsp27 and CBP in THP‐1 cells, and found that phosphorylated Hsp27 was critical to the protein level of CBP. Furthermore, in exploring the signaling mechanisms underlying its action, we found that p38MAPK‐MK2‐Hsp27 regulated NF‐κB via CBP, which acted as a multi‐protein complex assembly scaffold. Finally, we demonstrated that phosphorylated Hsp27 reduced reactive oxygen species accumulation thereby significantly repressed LPS‐induced excessive increase of CBP. Taken together, our data demonstrated that Hsp27, in its phosphorylation state, plays a critical role in controlling LPS‐induced inflammatory response by modulating CBP.
Extended suicide, or homicide followed by suicide
Authors: Gunn John C. 
Published: September 2019

AbstractBackgroundSuicide with accompanying homicide is frightening and ill understood.AimsTo raise professional awareness of its complexities and difficulties and identify areas for developing research.MethodA Crime in Mind seminar was held in London in December 2018, with four expert presentations and discussion. This paper draws on that seminar and supplementary literature.FindingsHomicide/suicide is very difficult to predict and thus prevent. Victims and perpetrators may have a dependency relationship. Better training, especially of general practitioners, may increase the likelihood of detecting signs of despair and delusional ideas. Psychiatrists should be more alert to fixed delusions and homicidal thoughts. Individual assessment and management alone is unlikely to be sufficient. Public health strategies are likely to be important too. Weapons control is vital. Employers of people with great personal responsibility and special access to potentially lethal tools, such as airline pilots, and perhaps clinicians, should have regular, compulsory, mental health checks.ConclusionsSix points of clinical importance emerged, including lowering the threshold for diagnosing delusional disorder and the establishment of anti‐violence clinics.
Mid‐term outcome in patients with bicuspid aortic valve stenosis following transcatheter aortic valve replacement with a current generation device: A multicenter study
Authors: Attinger‐Toller Adrian , Bhindi Rahul , Perlman Gidon Y. , Murdoch Dale , Weir‐McCall Jonathan , Blanke Philipp , Barbanti Marco , Sathananthan Janarthanan , Ruile Philipp , Gandolfo Caterina , Saia Francesco , Nietlispach Fabian , Wood David , Leipsic Jonathon , Webb John G. 
Published: September 2019

AbstractObjectivesTo perform clinical and echocardiographic follow‐up beyond 1 year in consecutive patients with severe bicuspid aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) with a current generation balloon‐expandable valve.BackgroundTreatment of bicuspid aortic valve disease with TAVR remains controversial and late follow‐up data is still scarce.MethodsWe collected baseline characteristics, procedural data, 30‐day and mid‐term clinical follow‐up findings from six centers in Europe and Canada from patients with bicuspid AS treated with TAVR using the SAPIEN 3 valve.ResultsSeventy‐nine patients underwent TAVR. Mean age was 76 ± 9 years; median STS risk score for mortality was 3.8% (interquartile range 2.3–5.5%). Median follow‐up was 390 days (interquartile range 138–739 days). Device success was achieved in 95% of patients. Postimplantation mean aortic gradient decreased from 50.2 ± 16.2 to 8.8 ± 4.4 mmHg and no patient had more than mild aortic regurgitation. At last follow‐up, there was persistent good valve performance. At 30 days and 1 year, the rates of all‐cause mortality were 3.8 and 7.7%, stroke 1.2 and 1.2%, and the rate of new pacemakers 18 and 18%.ConclusionsOur data confirm that treating patients with stenotic bicuspid aortic valves is safe, effective, and has favorable valve performance over time.
Temporal patterns and predictors of receiving no active treatment among older patients with acute myeloid leukemia in the United States: A population‐level analysis
Authors: Zeidan Amer M. , Podoltsev Nikolai A. , Wang Xiaoyi , Bewersdorf Jan Philipp , Shallis Rory M. , Huntington Scott F. , Gore Steven D. , Davidoff Amy J. , Ma Xiaomei , Wang Rong 
Published: September 2019

BackgroundThe majority of patients with acute myeloid leukemia (AML) are aged >65 years at the time of diagnosis and are not actively treated. The objective of the current study was to determine the prevalence, temporal trends, and factors associated with no active treatment (NAT) among older patients with AML in the United States.MethodsA retrospective analysis was performed of Surveillance, Epidemiology, and End Results (SEER)–Medicare data from 14,089 patients with AML residing in the United States who were diagnosed with AML at age ≥66 years during 2001 through 2013. NAT was defined as not receiving any chemotherapy, including hypomethylating agents. Multivariable logistic regression models were used to analyze sociodemographic, clinical, and provider characteristics associated with NAT.ResultsThe percentage of patients with NAT decreased over time from 59.7% among patients diagnosed in 2001 to 42.8% among those diagnosed in 2013. The median overall survival for the entire cohort was 82 days from the time of diagnosis. Patients treated with NAT had worse survival compared with those receiving active treatment. Variables found to be associated with higher odds of NAT included older age, certain sociodemographic characteristics (household income within the lowest quartile, residence outside the Northeast region of the United States, and being unmarried), and clinical factors (≥3 comorbidities, the presence of mental disorders, recent hospitalization, and disability).ConclusionsGreater than one‐half of older patients with AML residing in the United States do not receive any active leukemia‐directed therapy despite the availability of lower intensity therapies such as hypomethylating agents. Lack of active therapy receipt is associated with inferior survival. Identifying predictors of NAT might improve the quality of care and survival in this patient population, especially as novel therapeutic options with lower toxicity are becoming available.
Current clinical management of patients with glioblastoma
Authors: Lowe Stephen , Bhat Krishna P. , Olar Adriana 
Published: September 2019

AbstractBackgroundGlioblastoma (GB) is the most aggressive primary brain tumor, historically resistant to treatment, and with overall fatal outcome.Recent findingsRecently, several molecular subgroups and rare genetic alterations have been described in GB. In this review article, we will describe the current clinical management of patients with GB in the United States, discuss selected next‐generation molecular‐targeted therapies in GB, and present ongoing clinical trials for patients with GB. This review is intended for clinical and preclinical researchers who conduct work on GB and would like to understand more about the current standard of treatment of GB patients, historical perspectives, current challenges, and ongoing and upcoming clinical trials.ConclusionsGB is an extremely complex disease, and despite recent progress and advanced therapeutic strategies, the overall patient's prognosis remains dismal. Innovative strategies and integrative ways of approach to disease are urgently needed.
Min‐Oo Conjecture for Fully Nonlinear Conformally Invariant Equations
Authors: Barbosa Ezequiel , Cavalcante Marcos Petrúcio , Espinar José María 
Published: September 2019

AbstractIn this paper we show rigidity results for supersolutions to fully nonlinear, elliptic, conformally invariant equations on subdomains of the standard n‐sphere under suitable conditions along the boundary. We emphasize that our results do not assume concavity on the fully nonlinear equations we will work with.This proves rigidity for compact, connected, locally conformally flat manifolds (M, g) with boundary such that the eigenvalues of the Schouten tensor satisfy a fully nonlinear elliptic inequality and whose boundary is isometric to a geodesic sphere ∂D(r), where D(r) denotes a geodesic ball of radius r ∈ (0, π/2] in , and totally umbilical with mean curvature bounded below by the mean curvature of this geodesic sphere. Under the above conditions, (M, g) must be isometric to the closed geodesic ball .As a side product, in dimension 2 our methods provide a new proof to Toponogov's theorem about rigidity of compact surfaces carrying a shortest simple geodesic. Roughly speaking, Toponogov's theorem is equivalent to a rigidity theorem for spherical caps in the hyperbolic three‐space ℍ3. In fact, we extend it to obtain rigidity for supersolutions to certain Monge‐Ampère equations. © 2019 Wiley Periodicals, Inc.
Load balancing in cloud computing using water wave algorithm
Authors: V Arulkumar , Bhalaji N. 
Published: September 2019

SummaryCloud computing as of late is a rising innovation for giving various administrations through internet to fulfil the requisites of clients dependent on needs with minimal expense. The client can benefit all kind of administration without building, observing, and keeping up the assets. Researchers developed distinctive asset planning calculation to satisfy the client requisites as per their condition. This article proposes a Water Wave Algorithm (WWA) for resource scheduling in cloud environment. The results for throughput, Response time, Turnaround time, Migration time, Resource utilization, Fault tolerance, and scalability over FCFS, MCT, MET, and OLB algorithms and the results prove that WWA provides better results for throughput, response time, resource utilization, and scalability.
Characterization of Thermal and Electronic Conductivities of Catalyst Layers of Polymer Electrolyte Membrane Fuel Cells
Authors: Ahadi M. , Jankovic J. , Tam M. , Zahiri B. , Saha M. S. , Stumper J. , Bahrami M. 
Published: September 2019

AbstractThis work proposes new and accurate systematic methodologies for ex situ measurements of through‐plane thermal and in‐plane electronic conductivities of catalyst layers (CLs) of polymer electrolyte membrane fuel cells (PEMFC). The developed methods are based on measurements of different thicknesses/lengths of a CL on different substrates. Suitability of the proposed methods is confirmed through a set of microstructural properties measurements on a typical CL design to ensure the measured CLs would be representative of CLs in a real fuel cell product. Conductivity measurements of two CL designs with different compositions and microstructures confirm capability of the developed procedures to track structural changes in CLs. The present characterization platform is not limited to CLs and may be used for other composite porous materials with similar structures.
Meteorological observations for Eversleigh Station, near Armidale, New South Wales, Australia: 1877–1922
Authors: Bridgman Howard , Ashcroft Linden , Thornton Ken , Di Gravio Gionni , Oates William 
Published: September 2019

AbstractHistorical weather observations on the daily scale are vital for the improvement of reanalysis products and the analysis of long‐term variability of extreme events. While daily datasets extend for several centuries in parts of the Northern Hemisphere, the majority of historical data for the Southern Hemisphere are monthly averages or totals. In this paper, we describe a newly recovered dataset of ten daily meteorological variables for 1877 to 1922 from Eversleigh, a property in the New England region of New South Wales in Australia. Here, we present the full process of data rescue, from digitization to quality control and an assessment of homogeneity. We show that the majority of variables were recorded to a high standard and that the data are of general use for climate analysis. Forty years of daily temperature, cloud cover, wind, and pressure observations are now available for the New England Plateau, offering data that are more complete than any other records for the region in the Australian Bureau of Meteorology dataset. The Eversleigh dataset now provides an opportunity to gain more insight into the 19th century weather and climate of eastern Australia during a time of large interannual climate variability before the dominant impact of an anthropogenic warming signal.
Forearc tectonic evolution in the middle of the Bangong–Nujiang Tethys Ocean: New geochemical evidence of the Lanong ophiolites from the Zangbei lakes region
Authors: Yang Peng , Huang Qiangtai , Xia Bin , Ren Zhanli , Cai Zhourong , Zheng Hao , Lu Xingxin 
Published: September 2019

The middle of the Bangong–Nujiang Suture (BNS) in the central Tibetan Plateau hosts a series of dismembered ophiolitic fragments that document the evolution of part of the Tethys Ocean. However, the origin of these ophiolitic fragments in the Zangbei lakes region remains debated. Using new and existing field observations and petrographic, geochronologic, isotopic, and whole‐rock chemical data from ophiolitic rocks in the Zangbei lakes region, we evaluate their origins and constrain the tectonic evolution of the Bangong–Nujiang Tethys Ocean (BNTO). The Lanong peridotites have low rare‐earth element (REE) concentrations and typically exhibit U‐shaped REE patterns that are similar to those of forearc peridotites from South Sandwich and Xigaze. Lanong basalts and others mafic rocks from the Zangbei lakes region show enrichment in large‐ion lithophile elements and depletion in high‐field‐strength elements, and they have clear forearc and boninitic affinities in various tectonic discrimination diagrams. In addition, the Lanong basalts have initial 143Nd/144Nd ratios of 0.512307 to 0.512773, and εNd(t) values of −2.7 to +6.3. Considering the regional geology, previous geochronologic data from the ophiolitic fragments (147.6 ± 2.3 Ma to 189.8 ± 3.3 Ma) and the Darutso high‐Mg andesites (161.5 ± 0.9 Ma to 164.2 ± 1.4 Ma), and the lack of Jurassic arc‐related rocks in the northern Lhasa terrane, we conclude that the Jurassic ophiolitic fragments of the Zangbei lakes region were derived from a depleted mantle source and formed in a forearc basin in response to north‐directed subduction of the BNTO.
Seal of Biliteracy Graduates Get Critical: Incorporating Critical Biliteracies in Dual‐Language Programs and Beyond
Authors: Colomer Soria E. , Chang‐Bacon Chris K. 
Published: September 2019

AbstractResearch has suggested that U.S. K–12 dual‐language and Seal of Biliteracy programs do not benefit all students equally in their recognition of students’ multilingual competencies. The authors explored the perspectives of high school Seal of Biliteracy graduates: how they conceptualized the seal and the benefits that they had or had not derived from attaining it. Through a framework of critical biliteracies, the authors drew on interview data with Seal of Biliteracy graduates to highlight the dynamics of culture, race, and power inherent to both biliteracy and bilingualism. Attention was given to how biliteracy was defined, curricular framing, and who benefited from having received the seal. Findings revealed that Seal of Biliteracy benefits were often unevenly distributed across Latinx and white participants, yet also demonstrated community building among dual‐language graduates and beyond. The authors provide recommendations for engaging a critical biliteracies approach across district, program, and classroom levels.
Population Pharmacokinetics of Galcanezumab, an Anti‐CGRP Antibody, Following Subcutaneous Dosing to Healthy Individuals and Patients With Migraine
Authors: Kielbasa William , Quinlan Tonya 
Published: September 2019

AbstractGalcanezumab is a humanized immunoglobulin G (IgG) monoclonal antibody (mAb) indicated for the prevention of migraine that binds to calcitonin gene‐related peptide. A population pharmacokinetic (PK) analysis was performed to characterize galcanezumab PK using data pooled from 7 clinical studies. Clinical studies included healthy individuals and patients with episodic or chronic migraine who were administered between 5 and 300 mg galcanezumab. The PK data were analyzed using nonlinear mixed‐effects modeling. Galcanezumab concentration‐time data were described with a 1‐compartment model with first‐order absorption following subcutaneous administration and linear elimination. At the median body weight of 74 kg, the estimated population apparent clearance (CL/F) was 0.00785 L/h (34% IIV), the apparent volume of distribution was 7.33 L (34% IIV), and half‐life was 27 days. Patient body weight was found to have a modest effect of CL/F, with median galcanezumab concentrations being lower in the heaviest patients compared to the lightest patients, but this outcome was determined not to be clinically relevant in the context of model‐estimated random variability. Dosing adjusted for body weight is not warranted in adults. Age, sex, race/ethnicity, immunogenicity, renal/hepatic markers, and injection‐site location did not affect galcanezumab PK. In conclusion, galcanezumab exhibits PK parameters typical for an IgG mAb administered subcutaneously. The population PK model developed in this study demonstrates that galcanezumab exhibits linear PK that was not influenced in a clinically relevant manner by the patient factors evaluated.
TMPO‐AS1 promotes cervical cancer progression by upregulating RAB14 via sponging miR‐577
Authors: Yang Jian , Liang Baoquan , Hou Shunyu 
Published: September 2019

AbstractBackgroundAccumulating evidence has shown that long non‐coding RNAs play a key role in cancer initiation and development. However, the effect of TMPO antisense RNA 1 (TMPO‐AS1) on the progression of cervical cancer (CC) remains to be determined.MethodsThe mRNA expression of TMPO‐AS1, miR‐577 and RAB14 was measured by a quantitative reverse transcriptase‐polymerase chain reaction. The protein level of RAB14 was detected by western blotting. The function of TMPO‐AS1 in CC was measured via Cell Counting Kit‐8, 5‐ethynyl‐2′‐deoxyuridine and transwell assays, as well as by flow cytometry analysis. Nuclear‐cytoplasmic fractionation and RNA‐fluorescence in situ hybridization validated the subcellular position of TMPO‐AS1. An interaction between miR‐577 and TMPO‐AS1 or RAB14 was confirmed by luciferase reporter, RNA pull‐down and RNA immunoprecipitation assays.ResultsTMPO‐AS1 was highly expressed in CC. In addition, TMPO‐AS1 knockdown inhibited proliferation and migration, and also induced apoptosis. TMPO‐AS1 located in the cytoplasm and promoted RAB14 expression by absorbing miR‐577. RAB14 overexpression or miR‐577 knockdown restored the suppressing effect of TMPO‐AS1 knockdown on the biological behavior of CC cells.ConclusionsThe present study has revealed a novel TMPO‐AS1/miR‐577/RAB14 regulatory axis in the pathogenesis of CC, highlighting TMPO‐AS1 as a promising therapeutic target for CC patients.
Evidence of low‐temperature phase transition in BaTiO3‐modified NaNbO3: Raman spectroscopy study
Authors: Jauhari Mrinal , Mishra Sanjay Kumar , Poswal Himanashu Kumar , Mittal Ranjan , Chaplot Samrath Lal 
Published: September 2019

AbstractThe solid solution of NaNbO3 modified by 5% BaTiO3 (NNBT05) is investigated by Raman spectroscopic technique as a function of temperature from 83 to 298 K. Detailed mode analysis revealed that the Raman bands at ~112.8 and 277.1 cm−1 (at 298 K) disappear due to change in the symmetry of the structure at low temperature of 83 K. Further, rapid changes in the position of the Raman bands at 58.7 and 606.4 cm−1 (at 298 K) as a function of temperature provide evidence for the structural phase transition. These changes in the Raman spectra occur at different temperatures in the cooling and heating cycles as in a hysteresis loop, which provide evidence of the first‐order nature of the phase transition at low temperature.
QUANTIS: Data quality assessment tool by clustering analysis
Authors: Symoens Steffen H. , Aravindakshan Syam Ukkandath , Vermeire Florence H. , De Ras Kevin , Djokic Marko R. , Marin Guy B. , Reyniers Marie‐Françoise , Van Geem Kevin M. 
Published: September 2019

AbstractAutomatically generated kinetic networks are ideally validated against a large set of accurate, reproducible, and easy‐to‐model experimental data. However, although this might seem simple, it proves to be quite challenging. QUANTIS, a publicly available Python package, is specifically developed to evaluate both the precision and accuracy of experimental data and to ensure a uniform, quick processing, and storage strategy that enables automated comparison of developed kinetic models. The precision is investigated with two clustering techniques, PCA and t‐SNE, whereas the accuracy is probed with checks for the conservation laws. First, the developed tool processes, evaluates, and stores experimental yield data automatically. All data belonging to a given experiment, both unprocessed and processed, are stored in the form of an HDF5 container. The demonstration of QUANTIS on three different pyrolysis cases showed that it can help in identifying and overcoming instabilities in experimental datasets, reduce mass and molar balance closure discrepancies, and, by evaluating the visualized correlation matrices, increase understanding in the underlying reaction pathways. Inclusion of all experimental data in the HDF5 file makes it possible to automate simulating the experiment with CHEMKIN. Because of the employed InChI string identifiers for molecules, it is possible to automate the comparison experiment/simulation. QUANTIS and the concepts demonstrated therein is a potentially useful tool for data quality assessment, kinetic model validation, and refinement.