bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in the frequency of restorer-of-fertility 1 haplotype are associated with crop history of garden beet and sugar beet (Beta vulgaris L.)
Authors: Taniguchi Eigo , Kanomata Yohei , Tanaka Haruto , Oishi Mion , Hayakawa Ryo , Matsuhira Hiroaki , Narihiro Tsubasa , Kuroda Yosuke , Kagami-Katsuyama Hiroyo , Kubo Tomohiko , Kitazaki Kazuyoshi 
Published: December 2024

Abstract

Cytoplasmic male sterility (CMS) is used in breeding to facilitate hybrid seed production. Restorer of fertility (Rf), the suppressor of CMS, consists of a gene cluster with multiple haplotypes. Selection of restoring or non-restoring alleles depends on the discrimination of Rf haplotypes using DNA markers. The efficacy of this system is decreased if the Rf haplotype differs within the population of interest, which can occur during the crop evolution. In sugar beet, the Rf1gene has multiple haplotypes that are grouped by a linked polymorphic region (s17), with one group, termed p4, uniquely linked to the recessive rf1haplotype. Garden beet is the predecessor cultivar group of the sugar beet group. We questioned whether Rf1 haplotypes differ between these two cultivar groups to assess the utility of marker-assisted selection. We analyzed 48 garden beet landraces and observed differences in the s17 polymorphism compared to sugar beet, suggesting that the Rf1 haplotype frequency has changed during evolution of the crop. We next selected non-restoring genotypes from the garden beet landraces through test crosses and identified three recessive rf1 haplotypes: one is identical to the p4 haplotype and the others are novel haplotypes. The p4 haplotype occurs in a few accessions and its frequency in garden beet is approximately 0.01. We analyzed the s17 polymorphism in modern garden beet hybrids and their constituents. We identified the p4 haplotype and suggest the presence of other recessive rf1 haplotypes. Selection of p4 haplotype was efficient on the identification of non-restoring genotype in garden beet.
Recovery of saltmarsh macroinfauna after the Deepwater Horizon Oil Spill
Authors: Pant Manisha , Fleeger John , Johnson David , Riggio Rita , Hou Aixin , Deis Donald 
Published: December 2024

Abstract

To examine invertebrate resiliency after the 2010 Deepwater Horizon oil spill, we monitored the recovery of macroinfauna in replicated reference, moderately and heavily oiled salt marshes in Barataria Bay Louisiana for 8.5 y after the spill. Plants suffered near 100% mortality in heavily oiled marshes, profoundly altering the sedimentary environment. Plants in moderately oiled marshes did not suffer extensive mortality but experienced reduced above- and belowground plant biomass. A community analysis based on 40 macroinfaunal taxa was conducted during early, 2011–2012, middle, 2013–2017 and late, 2017–2018, stages of recovery. The early stage was marked by very low taxonomic diversity and low total macroinfaunal abundance in all marshes, while the middle stage was denoted by relatively high diversity and very high abundances in heavily oiled marshes where densities far exceeded reference and regional means. The community in the heavily oiled marshes diverged from reference and moderately oiled marshes during the middle recovery period when the crustaceans Apocorophium louisianum and Leptochelia rapax, the polychaete Alitta succinea, and oligochaetes dramatically increased in abundance, while at the same time, abundance increases of the polychaetes Manayunkia aestuarina, Streblospio gynobrachiata, and Capitellidae sp. lagged behind increasing trends at reference and moderately oiled sites. Macroinfaunal community similarity in moderately oiled marshes differed from reference and heavily oiled marshes in all three recovery stages but did not differ from reference sites on the last collection date. Heavily oiled community similarity not only differed from moderately oiled and reference marshes in all three recovery stages but remained different from reference sites on the last collection date. These observations indicate that moderately oiled marshes recovered by about 8 years, but that heavily oiled marshes require more than a decade to achieve resiliency.
Quantum Bioinformatics: A Novel Approach to Understanding Diabetes Mellitus
Authors: Andrade Luis Jesuino de Oliveira , de Oliveira Gabriela Correia Matos , Andrade João Cláudio Nunes Carneiro , Bittencourt Alcina Maria Vinhaes , de Oliveira Luisa Correia Matos , de Oliveira Luís Matos 
Published: December 2024

Abstract

Introduction: Diabetes mellitus (DM) is a complex metabolic disorder posing a significant global health concern. While classical biochemical models have provided valuable insights, the underlying molecular mechanisms of this disease remain incompletely understood. Recent advancements in quantum mechanics and bioinformatics have opened new avenues for exploring the quantum nature of biological processes, including those involved in DM.
Objective: To investigate the potential role of quantum mechanics in the pathophysiology of DM by employing a multidisciplinary approach that integrates quantum mechanical calculations with bioinformatics analysis.
Methods: A comprehensive dataset of proteins implicated in DM was curated from the Protein Data Bank. Quantum mechanical calculations, including Density Functional Theory and Time-Dependent Density Functional Theory, were performed to elucidate the electronic structure, vibrational properties, and potential quantum effects in key amino acid residues and active sites of these proteins. Bioinformatics tools were used to analyze protein-protein interaction networks, identify allosteric sites, and predict the impact of mutations on protein structure and function.
Results: Our findings provide strong evidence that quantum effects, particularly vibrational coherence and electronic tunneling, may play a crucial role in regulating enzymatic activity, protein-ligand interactions, and energy transfer processes involved in glucose metabolism and insulin signaling. Key findings include the identification of quantum tunneling pathways in key enzymes, evidence for quantum coherence in protein-protein interactions, and the role of vibronic coupling in modulating protein function.
Conclusion: This study offers a novel perspective on the molecular mechanisms underlying diabetes mellitus by integrating quantum mechanics and bioinformatics. Our findings suggest that quantum effects may contribute to the pathogenesis of DM, opening new avenues for the development of innovative diagnostic and therapeutic strategies.
High Prevalence of cognitive impairment in patients with Parkinson’s disease presenting to hospital
Authors: Tsui David S 
Published: December 2024

Abstract
The Parkinson’s passport is a compact document consisting facts and tips about managing PD. The aim of the study was to examine the impact of ‘The Parkinson’s Passport booklet’ on the care and management of patients with Parkinson’s admitted to an Australian hospital. The results suggest the implementation of the Parkinson’s passport booklet does not improve the care and the management of a patient with PD who present to hospital which in turn challenges the efficacy of the document. However, the major unexpected finding during the course of the study was a high incidence of cognitive impairment in PD patients (85%) presenting to hospital.
A literature review of Patient care in the management of agitation leading to violence and aggression in neuroscience nursing
Authors: Woon Caroline , Kivunja Stephen , Jameson Chantelle 
Published: December 2024

Abstract

Background
A correlation exists between staff retention, staff and patient safety and effective prevention of violence and aggression in neuroscience nursing. Workplace violence leads to a lack of productivity amongst nurses and legally a hospital is required to provide a safe working environment. This literature review aims to determine the themes within the literature and effective patient management of agitation leading to violence and aggression.

Aim
A literature review of articles was conducted using CINAHL, PubMed, Cochrane database and Google Scholar between 2007-2022.

Discussion
The common themes within the literature included assessment of the patient to identify an unmet need, early referrals to members of the interdisciplinary team, effective communication, verbal de-escalation techniques and an understanding of restraint and pharmaceutical management, even though these should be the last resort. Education for staff is fundamental and should include effective communication, warning signs, triggers for aggression, simulation in the clinical context, and verbal de-escalation techniques. Debriefing should take place after an incidence of violence and aggression and effective hospital management should be considered with guidelines and systems in place to support and protect staff and patients.
2022 Annual Demographic Survey of Parkinson's Disease and Movement Disorder Nurse Specialists
Authors: Williams Susan , Tsui David , Zeppel Melanie 
Published: December 2024

Abstract

Background
Parkinson's disease (PD) is a neurodegenerative condition that is the most common form of movement disorder. Caring for people with Parkinson's requires the skills and expertise of a Parkinson's disease and movement disorders nurse specialist (PDMDNS) (Bramble, Carroll, & Rossiter, 2018). The World Health Organisation has identified the importance of monitoring health workforce demographics and distribution trends in order to effectively plan for health care needs (WHO 2016). This is the third publication of an annual series reviewing the longitudinal trends of the PDMDNS workforce in Australia (Williams et al. 2021, Williams et al. 2023).
Spine Surgery and Home Again: The Nurse's Role in the Patient Journey
Authors: Foxall Kim , Hardman Catherine 
Published: December 2024

Abstract
Enhanced recovery after surgery (ERAS) programs – also referred to as fast-track programs - are multidisciplinary, evidence-based perioperative pathways, designed to achieve early recovery for patients undergoing major surgery (Ali et al., 2018). ERAS utilises strategies to optimise the patient's condition for surgery and recovery. In particular, the aim is to achieve an earlier discharge from hospital for the patient and a more rapid resumption of normal activities after surgery, without an increase in complications or readmissions (Dietz et al., 2019). An essential element of ERAS programs is multidisciplinary collaboration between surgical, anaesthetic, nursing and allied health teams. While elements of ERAS may vary between surgical units and hospitals, there are many common features in the preoperative, intraoperative and postoperative phases.
Minimally invasive spine surgery techniques and instrumentation have evolved rapidly over the past decade, and there is now a worldwide interest in ERAS programs for spine surgeries, including lumbar and cervical decompression and fusion procedures (Li et al., 2021). Nurses have a pivotal role in the successful implementation and sustainability of ERAS protocols because of their specialised knowledge and skill, and their constant presence throughout the patient care pathway (Wainwright et al., 2022). This publication presents learnings from the implementation of an ERAS program for minimally invasive spine surgery at Westmead Hospital, NSW.
Surgical site infections in neurosurgical patients following cranial surgery: An integrative review
Authors: Kivunja Stephen 
Published: December 2024

Abstract

Aim
To synthesise the literature pertaining to surgical site infections (SSIs) in neurosurgical patients following cranial surgery.

Background
SSIs in neurosurgical patients following cranial surgery present a major healthcare problem for healthcare providers worldwide. The most widely reported outcomes following SSIs include increased length of inpatient stay, morbidity, mortality, higher treatment costs and increased care burden for families and caregivers.

Design
Integrative review.

Methods
Using an integrative review framework, electronic database searches were conducted in CINAHL, Embase, Medline and ProQuest from 2012 – 2022. The search was limited to peer reviewed full text publications. Reference lists of identified studies were reviewed, and additional articles were accessed. Methodological rigour for included studies was evaluated using Critical Appraisal Skills Program tools.

Results
Twenty articles were reviewed, and four themes emerged relating to: preoperative patient preparatory practices and SSIs; risk factors for developing SSIs post cranial surgery; patient-reported outcomes and healthcare implications; and strategies for preventing SSIs within hospital settings.

Conclusion
Surgical site infections post cranial surgery among neurosurgical patients can be contained through administration of pre-surgical prophylactic antibiotics, adhering to aseptic hand hygiene, utilising evidence based infection control protocols, educating neurosurgical nurse clinicians in post cranial surgical wound care, and providing tailored education for patients and families in postoperative cranial surgical wound care.
Climate change and its impacts in extreme events in Morocco (observation, monitoring, and forecasting)
Authors: Hammoudy Wahib , Ilmen Rachid , Sinan Mohamed 
Published: December 2024

ABSTRACT
Rising extreme weather events in Morocco pose a growing threat to various socioeconomic sectors. These events, including heatwaves and cold spells, are exhibiting an alarming increase in intensity, frequency, and duration. To understand this trend and its future implications, a comprehensive study is essential. So, this research investigates the link between climate change and extreme weather events. It specifically focuses on how climate change influences the occurrence and intensity of these extremes. The study employs two main phases: Phase 1 is about the historical analysis (1984–2018). This phase uses robust methods like Sen's slope test for trend estimation and Mann–Kendall test for significance to evaluate observed changes in climatic extremes. Phase 2 is about future projections (2041–2060). This phase utilizes four climate models to project future changes in thermal and rainfall extremes under the RCP 4.5 scenario. Five climate indices (Tmm, Tx90p, WSDI, PRCPTOT, and SPI) are employed for analysis. Historical analysis reveals a significant increase in hot extremes across Morocco. Rainfall extremes, however, show no significant changes in trends. Future projections for all four climate models agree on significant warming in Morocco. They also project a decrease in annual precipitation across most of the country.
Towards phosphorus circularity: biofilm EBPR with subsequent struvite production at the Hias WWTP: insights from full-scale and laboratory testing
Authors: Eikås Sondre , Glestad Hans Emil , Marsteng Jansen Katrine , Sørensen Gjermund 
Published: December 2024

ABSTRACT
With the objective of reducing its CO2 footprint and moving towards circularity by recovering influent phosphorus, Hias wastewater treatment plant (WWTP) has developed a novel biological removal process (the Hias Process) which combines enhanced biological phosphorus removal (EBPR) and moving bed biofilm reactor and is now operating at full scale. Additionally, a struvite reactor is installed to capture phosphorus from the resulting sludge. In this work, the performance of the WWTP and particularly the biological phosphorus removal process and struvite reactor is assessed with regards to circularity and recovery of phosphorus. The Hias Process demonstrates stability and effectiveness even in cold climates and during stormwater events. Introducing the Hias Process reduced the use of precipitation chemicals, leading to a lower carbon footprint. The combination of the Hias Process with subsequent struvite reactor contributes to increased phosphorus circularity. That is achieved through improved plant availability of phosphorus in biosolids and the production of struvite. Main factors affecting recovery of phosphorus are identified and include the use of precipitation metals, bypass of the EBPR, and temperature's impact on PO4 release from EBPR sludge. This study aligns with Sustainable Development Goals and emphasizes efficient phosphorus recovery through the Hias Process and struvite reactor.
Influence of aqueous constituents on hexafluoropropylene oxide trimer acid (HFPO-TA) defluorination by UV/sulfite/iodide system
Authors: Gao Jie , Zhang Chaojie , Chu Liquan , Zhao Yunmeng , Zhai Zhenyu , Zhou Xuefei , Zhang Yalei 
Published: December 2024

ABSTRACT

Hexafluoropropylene oxide trimer acid (HFPO-TA) is an emerging alternative to traditional perfluoroalkyl substances (PFASs), which is characterized by its biotoxicity and persistence. The UV/sulfite/iodide photo-induced hydrated electrons system can effectively degrade HFPO-TA under mild conditions. However, the effects of water quality on this system need to be urgently investigated. This study explored the impact of common aqueous constituents, such as Cl-, HCO3-, PO43- and humic acid (HA) on the defluorination efficiency of HFPO-TA by the UV/sulfite/iodide system. Results indicated that low concentrations of Cl- (&lt;1.0 mM), PO43- (&lt;0.01 mM), and HA (&lt;1.0 mg/L) have little effect on defluorination efficiency. However, as concentrations increase, these constituents can interact with photosensitizers or reactive species within the system, leading to a decrease in defluorination efficiency. HCO3-, in their various solution states, can compete with HFPO-TA for the hydrated electron (eaq-) or engage directly with the photosensitizer, resulting in a hindrance to the defluorination capabilities of the system. Furthermore, it was identified that the components in Xiaoqing River, especially Cl- and HCO3-, could greatly inhibit the defluorination and degradation efficiency of HFPO-TA by the system. Pretreatment such as nanofiltration would effectively mitigate this problem.
Capsaicin: Unveiling its Therapeutic Potential and Pharmacological Actions
Authors: Sinha Sonal , Gupta Sanjay Kumar , Sahu Pankaj , Gupta Aakash , Ajazuddin  
Published: December 2024

Abstract:
This article offers in-depth information on the pharmacological effects, historical
background, and chemical makeup of capsaicin, the primary ingredient in chili peppers. Capsaicin
was first discovered in Mexico about 5000 BC, and it has since changed from being a culinary
spice to a substance with substantial medicinal potential. It covers the chemical characteristics of
capsaicin, how it activates the sympathetic nervous system, and how to measure the heat level of
capsaicin using the Scoville Heat Unit (SHU) scale. The production of capsaicin in plants, its
connection to substance P and CGRP, and the TRPV1 receptor are all explained in further depth.
The article discusses capsaicin's many pharmacological impacts, such as painkilling, antiinflammatory,
antioxidant, antibacterial, cardiovascular, and anti-obesity properties; the article
also discusses the spice's pharmacokinetics and mechanisms of action. A summary of current
clinical trials indicates continued interest in the possible medical applications of capsaicin. The
wealth of data that this analysis concludes highlights capsaicin as a viable topic for more research
and development in medicine and healthcare.
Evaluation of the Hypoglycemic Activity of Methanolic Extract of Foeniculum vulgare in Streptozotocin-induced Diabetic Wistar Rats
Authors: Bougrine Soukaina , Abouyaala Oumaima , Elgui Radia , El Brouzi Mohamed Yassine , Sow Brahim , Elmotia Khadija , El hessni Aboubaker , Mesfioui Abdelhalem , Ouahidi Moulay Laarbi 
Published: December 2024

Objective:
This study aimed to assess the hypoglycemic effects of methanolic extract
of Foeniculum vulgare in male Wistar rats that were diabetic due to streptozotocin.

Methods:
Experimental diabetes was initially induced in male Wistar rats by intravenous injection
of streptozotocin (55 mg/kg). Subsequently, the rats received daily oral administration of the
methanolic extract of Foeniculum vulgare (250 mg/kg) and the standard drug metformin (300
mg/kg) for 28 days. Furthermore, a tolerance test was carried out.

Results:
The study findings suggest that the diabetic rats in the untreated control group showed
hyperglycemia and significant weight loss, as well as polydipsia, polyphagia, and polyuria.
However, rats treated with methanolic extract of Foeniculum vulgare for 28 days showed a significant
reduction in blood glucose levels and a marked improvement in body weight. Additionally,
there was a notable decrease in the daily rate of food consumption and water intake and a
significant reduction in serum glucose level, triglycerides, total cholesterol, creatinine, urea,
AST, and ALT levels compared to the untreated diabetic control group. Histopathological examination
revealed that after 28 days of treatment with 250 mg/kg of methanolic extract of the Foeniculum
vulgare, the size of the islets of Langerhans in the pancreas tissue was decreased. Moreover,
liver tissue demonstrated normalization with a normal central lobular structure, and kidney
tissue showed normalization with a normal Bowman's capsule.

Conclusion:
These findings suggest that the methanolic extract of Foeniculum vulgare can potentially
treat diabetes and should be evaluated further for drug development.
Exploring Fuzzy Logic as an Alternative Approach in Psychological Scoring
Authors: Kyriazos Theodoros , Poga Mary 
Published: December 2024

Introduction
Accurate measurement is foundational to psychological assessments, influencing research validity, clinical practice, and societal applications. While extensively utilized, traditional scoring methods suffer from limitations in granularity, sensitivity, and adaptability, potentially impacting the precision and utility of these assessments. This study aims to explore the efficacy of fuzzy logic as an alternative scoring method for the Satisfaction with Life Scale (SWLS), addressing these limitations.

Methods
A cross-sectional design involving 1,230 Greek adults was employed to compare traditional scoring methods with fuzzy logic. Data were collected online and analyzed using descriptive statistics, Pearson correlation, paired t-tests, regression analysis, and sensitivity analysis to evaluate the robustness and reliability of fuzzy logic scoring.

Results
Results indicated that fuzzy logic scoring provides enhanced granularity and sensitivity, effectively capturing subtle variations in life satisfaction and mitigating ceiling and floor effects. The strong positive correlation (r = .9505) between traditional and fuzzy logic scores suggests high consistency. Significant mean differences highlighted the increased sensitivity of fuzzy logic scoring. The Bland-Altman plot confirmed good agreement between the methods, and sensitivity analysis demonstrated the robustness of fuzzy logic scoring across different parameter settings.

Conclusion
In conclusion, fuzzy logic offers a reliable and nuanced alternative to traditional scoring methods, significantly improving the accuracy and applicability of psychological assessments. Integrating fuzzy logic with advanced technologies could further enhance the precision and inclusivity of psychological evaluations, making it a promising tool for future psychological measurement.