bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations
Authors: Su Shicheng 
Published: November 2024

Summary:
The conventional wisdom is that the overwhelming majority of neoantigens arise from chromosomal DNA mutations; however, recent studies show that posttranscriptional and posttranslational events can also generate neoantigens. This commentary provides an overview of known and potential sources of nonchromosomal neoantigens, emerging technologies, and clinical trials that may move this field forward to redefine immunologically “hot/cold” tumors and develop next-generation immunotherapeutic approaches.
The Far Side of Resistance to RAS Inhibitors
Authors: Marasco Michelangelo , Misale Sandra 
Published: November 2024

Summary:In this issue, four articles highlight the critical role of nongenetic mechanisms and cell plasticity in mediating resistance to different classes of RAS inhibitors in pancreatic ductal adenocarcinoma and non–small cell lung cancer.See related article by Benitz et al., p. 2162See related article by Dilly et al., p. 2135See related article by Araujo et al., p. 2183See related article by Singhal et al., p. 2122
Alternate MHC I Antigen Presentation Pathways Allow CD8+ T-cell Recognition and Killing of Cancer Cells in the Absence of β2M or TAP
Authors: Cruz Freidrich M. , Orellano Laura A. A. , Chan Amanda , Rock Kenneth L. 
Published: November 2024

Abstract
MHC I antigen presentation allows CD8+ T cells to detect and eliminate cancerous or virally infected cells. The MHC I pathway is not essential for cell growth and viability, so cancers and viruses can evade control by CD8+ T cells by inactivating antigen presentation. In cancers, two common ways for this evasion are the loss of either the MHC I light chain [β2 microglobulin (β2M)] or the transporter-associated with antigen processing (TAP). β2M-null cells are generally thought to lack the MHC I pathway because the MHC I heavy chain by itself lacks the proper conformation for peptide display. TAP-null cells are thought to have severely defective MHC I antigen presentation because they are incapable of supplying peptides from the cytosol to MHC I molecules in the endoplasmic reticulum (ER). However, we have found that highly reactive memory CD8+ T cells could still recognize cells that completely lacked β2M or TAP. This was at least in part because in TAP-null cells, the Sec62 component of the Sec61 translocon supported the transfer of cytosolic peptides into the ER. In β2M-negative cells, free MHC I heavy chains were able to bind peptides and assume a conformation that was sufficiently recognized by CD8+ T cells. This process required ER chaperones and the peptide-loading complex. We found that these mechanisms supported antigen presentation at a level that was sufficient for memory CD8+ T cells to kill melanoma cells both in vitro and in tumor-bearing mice. The implications for tumor immunotherapy are discussed.
Network Bottlenecks and Task Structure Control the Evolution of Interpretable Learning Rules in a Foraging Agent
Authors: Giannakakis Emmanouil , Khajehabdollahi Sina , Levina Anna 
Published: November 2024

Abstract
Developing reliable mechanisms for continuous local learning is a central challenge faced by biological and artificial systems. Yet, how the environmental factors and structural constraints on the learning network influence the optimal plasticity mechanisms remains obscure even for simple settings. To elucidate these dependencies, we study meta-learning via evolutionary optimization of simple reward-modulated plasticity rules in embodied agents solving a foraging task. We show that unconstrained meta-learning leads to the emergence of diverse plasticity rules. However, regularization and bottlenecks in the model help reduce this variability, resulting in interpretable rules. Our findings indicate that the meta-learning of plasticity rules is very sensitive to various parameters, with this sensitivity possibly reflected in the learning rules found in biological networks. When included in models, these dependencies can be used to discover potential objective functions and details of biological learning via comparisons with experimental observations.
Individual and Situational Characteristics of the Occurrence of Cyber Sickness in the Context of Virtually Supported Military Training
Authors: Herchenröder Ansgar J.D. , Jacobsen Thomas , Herzberg Philipp Yorck , Gorzka Robert-Jacek 
Published: November 2024

Abstract
Cyber sickness (CS) is considered a major challenge in the use of virtual reality (VR). This impacts the planned implementation of VR in the training of operational forces. The present work aimed to investigate the prevalence and onset of CS during virtually supported military training using head-mounted displays (HMDs) and explore related predictor variables. For this purpose, a quantitative cross-sectional study was conducted in which German soldiers (N = 100) were exposed to an immersive fifteen-minute VR scenario. We measured CS severity, age, heart rate (HR), and skin conductance (SC). Using newly developed categories to classify CS severity, the results showed a small prevalence (4%) of CS in the studied sample. Susceptibility to CS was the only predictor of the occurrence of CS symptoms. Accordingly, the present work provides evidence that CS may play a minor role in affecting virtually supported operational training. At the same time, the easily detectable susceptibility to CS promises rapid detection of vulnerable users. Implications and further research are discussed to detect, control, and mitigate CS.
Against #CoronaJihaad: Online Somatic Nationalism and Offline Social Distancing in India during covid-19
Authors: Roohi Sanam 
Published: November 2024

Abstract
This article examines the two waves of the covid-19 pandemic in India in 2020–2021. It disaggregates the different narratives constructed by the Hindu right-wing in online circles. It shows that by instrumentalizing the interactive and multimodal features of social media, the Hindu Right amplified the notion of Muslims as contaminants in the first wave of the breakout, accusing them of weakening the otherwise sacred, virus-resistant Indian nation. During the second wave, the Hindu Right downplayed the role of the Kumbh Mela, a major Hindu pilgrimage and festival, as a super-spreader event. Criticisms of the Hindu festival was deemed a foreign conspiracy aimed at harming India’s body politic. The article argues that the Hindu Right capitalized on the covid-19 crisis to promote religified and somatisized ideals of a ‘muscular Hindu India’ weakened by the Muslim Other from within. This narrative heightened the schism between Hindus and Muslims in India, with long-lasting effects that outlive the pandemic itself. Finally, the article problematizes the notion that digital technologies and virtual spaces necessarily overcome physical barriers and divisions, arguing instead that in the case of the right-wing Hindu Twittersphere, social media congealed intra-communal solidarities and inter-communal antagonisms online echoing divisions in the non-digital, offline world.
‘Best Mosques Near Me’: American Muslims and Online Mosque-Finding
Authors: Stanton Andrea 
Published: November 2024

Abstract
This article uses digital and lived religion perspectives to analyze the phenomenon of American Muslims using online tools to search for and rate-and-review mosques. Focusing on four mid-size U.S. cities – Boston, Indianapolis, Denver, and Seattle – it surveys three major online sources for mosque finding: the Muslim-focused Salatomatic, the review site Yelp, and Google’s location-based search. By braiding together site content and user reviews, it shows how this phenomenon connects users’ functional goal of finding a location for daily or community prayer with the goal of a high-quality user experience. User reviews’ migration toward Google echo a broader shift from computer-based website engagement to mobile engagement and suggest the integration of U.S. mosques into the broader sphere of businesses and services. Overall, they point to the central role that online platforms play in contemporary United States Muslim religious life-worlds, extending review behaviors around consumer goods and services to religious ones.
Guiding the Pious Self: Morality and Affect in Muslim Instructional YouTube Videos
Authors: Malli Gabriel 
Published: November 2024

Abstract
Based on a discourse analysis of German-language YouTube videos that attempt to instruct their audiences in Islamic practice, the article examines the interplay of moral statements and audiovisual elements in religious web videos. YouTube constitutes an affective space for the promotion of normative Islamic models of gendered subjectivity that instruct how to understand and guide oneself. Considering the tensions in the lives of young Muslims in the German context, the videos offer clear notions of gendered Muslim morality within an arrangement of discursive and affective elements that draw on both Islamic oratory and elements of secular popular culture. On a linguistic level, producers address their audiences as immoral subjects alienated from a divine order and call for a self-transformation towards piety. At the audiovisual level, discursive statements are entangled with a fluctuating stream of affective intensities that have the potential to charge moral codes with aesthetic legitimacy and attach viewers to gender norms.
Effect of temperature on growth, metabolism, and gas exchange in Hermetia illucens larvae reared under commercial and laboratory conditions
Authors: Schøn M.L. , Mikkelsen M.V.N. , Jensen K. , Poulsen J.M. , Berggreen I.E. , Schou T.M. , Nørgaard J.V. , Overgaard J. 
Published: November 2024

Abstract
The world’s socio-economic development is continuously increasing the demand for efficient production of food, feed, and energy from the agricultural sector. In this respect, the emerging production of black soldier fly larvae (BSFL) represents a promising system to upscale low-quality resources to higher-quality resources usable as feed or biodiesel. To optimize BSFL production it is critical to establish methods that are relevant to examine how rearing conditions, including temperature, affect growth, metabolism, and body composition at large scale. In a first set of experiments, we therefore compared how small-scale laboratory respirometry chambers (600 larvae) support gas exchange, growth, and metabolism in BSFL with similar measurements obtained from large-scale commercial conditions (>12 million larvae) at ∼34-35 °C. Having observed that small- and large-scale systems generated comparable measurements of growth and metabolism, we used our small-scale respirometry system to examine in detail how substrate rearing temperature ranging from 27.0 to 41.9 °C influenced growth, metabolism, and body composition in BSFL. Here we found that 7-day growth of BSFL was stable and high at 27, 35, and 39 °C, while a rearing temperature of ∼42 °C caused a severe, but sublethal, depression of growth and metabolism. Despite the general similarities in total growth at 27, 35, and 39 °C, we found considerable acceleration of metabolism and development at the two higher rearing temperatures (35 and 39 °C). In contrast, the lower rearing temperature (27 °C) resulted in reduced CO2 production per kg larvae produced and the was associated with a higher crude protein to crude lipid ratio in larvae after the 7-day growth period. Based on these findings we discuss how continued monitoring of gas exchange in production systems holds a potential to optimize production in the emerging industry of large-scale commercial insect production.
Dominant Synoptic Systems for Summer Precipitation over the Complex Terrain of Southwestern China
Authors: Zhao Yin , Li Jian 
Published: November 2024

Abstract
Understanding precipitation over complex terrain, such as southwestern China, requires the consideration of both multiscale circulation and topography. First, the dominant synoptic system must be clarified, as it determines how multiscale topography affects precipitation. Here, based on a self-organizing map, large-scale winds are categorized into anomalous-westerly types, anomalous-easterly types, and transitional types. Four synoptic-scale systems (vortex type, cold-front type, tropical-depression type, and weak-synoptic-forcing type) dominate the summer precipitation. The vortex type occurs with strengthened large-scale westerlies, and its precipitation is distributed within the moisture convergence region. The cold-front type, tropical-depression type, and weak-synoptic-forcing type exhibit large-scale easterly anomalies. For the cold-front type, a low-level northeasterly blocked by topography shapes the northwest–southeast-oriented front zone at the upper highland slope. The precipitation frequency and intensity are high within the frontal zone, while the intensity is weak on both sides. For the tropical-depression type, moist low-level easterlies uplifted by westward-rising topography anchor precipitation at the lower slope. Large precipitation for the tropical-depression type is attributed to a high frequency. Large-scale horizontal winds are the weakest for the weak-synoptic-forcing type, and the local topography influences the scattered precipitation distribution. Both the frequency and intensity are high for the weak-synoptic-forcing type. Overall, long-lasting nocturnal events dominate the precipitation of the four synoptic types, while large-scale easterlies favor precipitation events with shorter durations and earlier peaks. For obvious synoptic systems, large-scale topography influences precipitation via a dynamic blocking effect, while the thermodynamic role of local topography is important with a weak-synoptic-forcing.

Significance Statement
Clarifying dominant synoptic systems is highly important for understanding precipitation over complex terrain, as the effect of topography on precipitation varies with different synoptic backgrounds. Taking southwestern China as a representative of complex terrain, this study objectively identified the dominant synoptic systems associated with summer precipitation. The distribution and fine-scale characteristics of precipitation have been further analyzed considering the combined influence of multiscale circulation and topography. In addition to advancing our understanding of precipitation in southwestern China, this study provides a reference for analyzing precipitation in other regions with complex terrains.
Psychological distress among nurses: Exploring the role of support in the work-place in Morocco
Authors: Alahiane Latifa , Ikrou Ali , Ventriglio Antonio , Essaffani Hicham , Zaam Youssef , Abouqal Redouane , Belayachi Jihane 
Published: November 2024

Aim: This study aimed to assess the psychological distress, specifically anxiety and depression, among nurses employed at University Hospital Center of Rabat in Morocco and tested the associations between support in the workplace and nurses’ psychological well-being. Methods: A cross-sectional observational study was conducted at University Hospital Center of Rabat in Morocco, based on a prospective data collection employing an ad-hoc self-report questionnaire. 223 nurses were enrolled with a minimum of 1 year of practice in any care unit. Socio-demographic and professional characteristics of each participant were included. A validated tool was utilized to measure the support from superiors and colleagues in the workplace, while the Hospital Anxiety and Depression Scale (HADS) was employed to evaluate anxiety and depression. Univariate and multivariate analyses were conducted to explore the relationships between different independent and dependent variables. Results: Significant socio-demographic and professional factors associated with increased anxiety included female gender, age over 41 years old, Baccalaureate level of education, intention to leave the hospital, and less support from superiors. Regarding the levels of depression, the Baccalaureate level of education was significantly associated with higher levels of depressive symptoms (β 2.444; CI [1.203, 3.686]). Conclusions: Our findings suggested that ensuring support from superiors was crucial for safeguarding the psychological well-being of nurses. Therefore, hospital managers should prioritize addressing the workplace support for professionals, and the organizational enhancement.
Evaluating the mechanical behavior of carbon composites with varied ply-thicknesses using acoustic emission measurements
Authors: Tariq Muzzamil , Scheffler Sven , Anilkumar PM , Sämann Philipp , Bülow Christian , Wiedemann Martin , Rolfes Raimund 
Published: November 2024

Laminates are produced by stacking prefabricated plies composed of fiber products. Within the aerospace industry, a ply thickness of 125 μm is commonly regarded as the standard. Ply thicknesses of less than 100 μm are generally considered as thin plies. Due to their ability to provide superior mechanical properties relative to conventional laminates thin-ply (TP) laminates are gaining interest in several high-tech industries. Although the research on TP laminates increased over the past few years, a comprehensive evaluation of the mechanical behavior of TP laminates accounting for the ply-thickness is an ongoing challenge due to the intricacies of ply interactions, and experimental difficulties. The mechanical response of fiber reinforced polymer laminates is governed by damage progression during loading, with the thickness of individual plies playing a crucial role in influencing the initiation and evolution of local cracks and failures. Therefore, in this study, the effective mechanical properties of carbon fiber reinforced polymer composite with varied ply thicknesses have been experimentally evaluated and the accumulation of the damage events has been monitored using acoustic emission measurements, utilizing a contactless laser vibrometer. In this experimental study, the ply thickness is increased in a systematic manner (ranging from 50 μm to 200 μm). Experimental investigation has been carried out in quasi-static tension and compression. The results show that unnotched TP laminates subjected to tensile loading demonstrate enhanced effective strength, attributed to less premature failure. Conversely, as the thickness of the lamina increases, there is a reduction in the overall strength of the laminate. However, in the case of the notched specimen lowest strength has been observed at a ply-thickness of 100 μm in this study. Under compressive loading, unnotched and notched specimen tends to show similar mechanical behavior to unnotched specimens under tensile loading. The overall strength is raised with decreasing ply thickness. The findings from this study may be valuable for incorporating ply-thickness considerations into models for predicting the mechanical performance of laminates under dynamic loading.
A randomized controlled trial comparing carbazochrome sodium sulfonate and tranexamic acid in reducing blood loss and inflammatory response after simultaneous bilateral total hip arthroplasty
Authors: Han Guangtao , Cai Lijun , Wang Qin , Li Qianhao , Kang Pengde 
Published: November 2024

Purpose A drug known as carbazochrome sodium sulfonate (CSS) can reduce blood loss. But, it is not known how it can prevent the development of hemostatic and inflammatory conditions in patients who undergo bilateral simultaneous total hip arthroplasty (SBTHA). This study will analyze the safety and effectiveness of combining this drug with SBTHA. Methods The study was conducted on 100 patients who underwent SBTHA with simultaneous total hip replacement. They were split into two groups: group B received TXA with CSS, group A received TXA with no CSS. The main observation of the study was the total blood loss, which is the most common indication of blood loss. Other secondary indicators of the study included hidden blood loss, postoperative blood transfusion rate, level of inflammatory reactants, hip function, pain score, venous thromboembolism (VTE) and the incidence of adverse events. Results Group B had significantly lower TBL and HBL compared to Group A. Group B showed significant improvement in inflammatory biomarker levels, blood transfusion rate when compared to Group A ( p < .05). No thromboembolic complications occurred in either group. There were no significant differences between the two groups in terms of postoperative swelling rate, intraoperative blood loss, visual analog scale pain score, platelet count, discharge motion and average length of stay. Conclusions As a hemostatic agent, CSS combined with TXA can reduce postoperative blood loss in patients undergoing SBTHA, and is more effective than TXA alone in terms of blood loss and inflammation, and does not increase the incidence of thromboembolic complications.
Paradigm Shifts in Education: An Ecological Analysis
Authors: Zhao (赵勇) Yong , Zhong (仲若君) Ruojun 
Published: November 2024

Purpose The purpose of this article is to analyze educational changes, in particular transformational changes, and suggest a new approach to shift the paradigm in education using an ecological conceptual framework. Design/Approach/Methods An ecological analysis of two key factors in education: prescribed curriculum and student autonomy. Findings Paradigm shift can happen in schools, but it cannot be imposed by systems, and systems typically are unable to propose transformational changes. Such changes should happen within schools, but not affecting the entire school. Thus a “school within a school” approach is proposed with some examples. The small change could affect entire systems from the perspective of panachy theory. Originality/Value This article brings a fresh perspective on making the much needed transformational changes possible in schools. AI partnership, personalized learning, student autonomy and self-determination, self-directed learning are all fascinating and hopeful ideas that could bring the best education possible for all students. But implementing these would demand a paradigm shift in schools. Schools are the most resilient social entities, but they are also the easiest to change organizations. For over 200 years, the essence of schooling has not changed, but there have been significant changes in curriculum, textbooks, testing, and pedagogy. Today, we need schools to operate with a different education paradigm to enable students to have more autonomy and control of their learning in order to survive and thrive in the uncertain age of Artificial Intelligence. It seems apparent that the school system has successfully resisted paradigm shifts or transformational changes.