bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic utility of linked color imaging in the evaluation of colonic mucosal inflammation in ulcerative colitis: a pilot study
Authors: Kanmura Shuji , Hamamoto Hitomi , Tanaka Akihito , Arima Shiho , Sasaki Fumisato , Tanoue Shiroh , Nasu Yuichiro , Hashimoto Shinichi , Higashi Michiyo , Ido Akio 
Published: July 2019

Abstract
Background and aims Recent studies recommend histological mucosal healing of intestinal tissue as a treatment goal in ulcerative colitis (UC). Linked-color imaging (LCI) is a new endoscopy system that enhances the color differences of the gastrointestinal mucosa. We investigated the efficacy of LCI in the evaluation of intestinal activity, including the histological activity in UC.
Method A total of 21 UC patients who were evaluated by the LASEREO system (FUJIFILM Co., Tokyo, Japan) were enrolled from August to December in 2016. All of the target points were observed by conventional white-light imaging (WLI) and LCI and biopsied from the region of interest in each view. We quantified the color tones of 73 biopsied points on WLI and LCI using the L*a*b* color value (WLI-L, WLI-a, WLI-b, and LCI-L, LCI-a, LCI-b). We then investigated the relationships among the L*a*b* color values, endoscopic findings, and histological healing.
Results The average LCI-a and LCI-b values of patients with high mucosal activity disease were significantly higher than in those with mucosal healing (P < 0.01), and only LCI-a was significantly correlated with the score for histological healing. With regard to the other color values (LCI-L and all WLI values), there were no statistically significant differences in terms of average color value and correlation between patients with high mucosal activity and those with mucosal healing. In addition, the difference in the average color values with LCI and WLI was 7.1 and 3.1, respectively.
Conclusion LCI is more useful than WLI for the visualization and evaluation of mucosal inflammation in UC.
A novel non-thermal resection tool in endoscopic management of scarred polyps
Authors: Kandiah Kesavan , Subramaniam Sharmila , Chedgy Fergus , Thayalasekaran Sreedhari , Venetz Daniel , Aepli Patrick , Bhandari Pradeep 
Published: July 2019

Abstract
Background and study aims Scarred polyps are challenging to resect using conventional endoscopic mucosal resection (EMR) techniques. The aim of this pilot study was to assess the feasibility of the EndoRotor device in resecting scarred polyps arising from previous endoscopic resection attempts.
Patients and methods This was a prospective pilot study of patients with scarred colonic polyps treated using EndoRotor carried out in two centers.
Results A total of 19 patients were included in this study. The overall cure rate using EndoRotor was 84 %; 10 patients (52.6 %) achieved cure after one attempt and six patients (31.5 %) achieved cure after two attempts. A total of three patients who had polyp recurrence after the first EndoRotor resection were referred for either endoscopic submucosal dissection (2 patients) or surgery (1 patient) due to difficult access. There were no perforations, delayed bleeding, post-polypectomy syndrome or complications requiring surgery.
Conclusions In this pilot study, the novel non-thermal device (EndoRotor) has been demonstrated to be a safe and effective technique in challenging management of scarred polyps. Further randomized controlled trials comparing this technique with APC, hot avulsion, ESD and endoscopic full-thickness resection are required to ascertain the utility of EndoRotor in the hands of non-expert endoscopists.
Einfache autologe Shuntrevision 1
Authors: Krönung Gerhard 
Published: July 2019

ZUSAMMENFASSUNGKnickstenosen sind ein häufiger Befund bei maturierten Shuntvenen. Die Indikation zur Revision ist funktionell (Rezirkulation, Armschwellung, parietale Thrombose etc.). Die Stenoseresektion mit venovenöser Patch-Reanastomose bietet sich als einfaches und effektives, autologes Standardverfahren an.
Medizinische Betreuung von jungen Frauen mit Ullrich-Turner-Syndrom in Deutschland
Authors: Dörr Helmuth-Günther , Bettendorf Markus , Binder Gerhard , Brämswig Jürgen , Hauffa Berthold P. , Holterhus Paul-Martin , Mohnike Klaus , Schmidt Heinrich , Stalla Günter K. , Wabitsch Martin , Wölfle Joachim ,   und die Turner-Syndrom-Vereinigung Deutschland e. V.
Published: July 2019

Zusammenfassung
Hintergrund Für die medizinische Betreuung von Frauen mit Ullrich-Turner-Syndrom (UTS) nach dem Ende der kinderärztlichen Betreuung liegen zahlreiche Empfehlungen vor. Es gibt bisher keine Untersuchung, die die Betreuungssituation der Frauen in Deutschland analysiert hat.
Methoden Die Untersuchung wurde bei Frauen mit UTS (Alter ≥ 18 Jahre; Median 25 Jahre) im Jahr 2015 mit einem Fragebogen durchgeführt, der von einer französischen Arbeitsgruppe entwickelt und mit deren Erlaubnis verwendet wurde. Alle Frauen wurden im Kindesalter mit Wachstumshormonen behandelt. Die Frauen wurden über 11 kooperierende Zentren und über die Selbsthilfegruppe UTS identifiziert und von dort angeschrieben. Insgesamt konnten 130 Fragebögen ausgewertet werden.
Ergebnisse Von den 130 Frauen gaben 79 Frauen (61 %) gesundheitliche Probleme an. Bei einem einzigen Facharzt waren 38 % und bei 2 Fachärzten 42 % der Frauen in Dauerbetreuung. Am häufigsten wurde der Gynäkologe mit 80,3 %, gefolgt vom Allgemein-/Hausarzt mit 53,8 % genannt. Der HNO-Bereich wurde von 35 % als Problembereich angegeben, aber nur 3 % der Frauen waren bei einem HNO-Arzt. Die Frage, ob in einem Zeitraum von 4 Jahren mindestens eine der folgenden Untersuchungen (Blutdruckmessung, Blutzucker, Blutfette, Leberwerte, Schilddrüsenhormone, Herz-Ultraschall und Audiogramm) erfolgt sei, wurde wie folgt beantwortet: Blutdruckmessung (85 %), Blutzucker (47 %), Blutfette (41 %), Leberwerte (46 %), Schilddrüsenhormone (44 %), Echokardiografie (57 %) und Audiogramm (35 %). Eine Untersuchung mit allen 7 Parametern wurde bei 9,8 % der Frauen durchgeführt. Bei 103 Frauen (80,5 %) wurde eine Hormonersatztherapie mit Sexualsteroiden durchgeführt. Weitere Medikamente nahmen 76 Frauen ein, wobei Schilddrüsenhormone (44 %) und Antihypertensiva (11 %) am häufigsten genannt wurden.
Schlussfolgerungen In der Studie wird erstmals die medizinische Versorgungssituation von jungen Frauen mit UTS analysiert. Die Ergebnisse zeigen, dass die Betreuung der Frauen nicht immer optimal ist, die Gründe dafür bleiben nach dieser Studie offen. Aufgrund der zahlreichen und unterschiedlichen Komorbiditäten ist die Betreuung der Frauen komplex und sollte daher multidisziplinär von verschiedenen Fachärzten unter der Leitung eines Arztes erbracht werden.
Detection of minimal mucosal esophageal lesions in non-erosive gastroesophageal reflux disease using optical enhancement plus optical magnification
Authors: Robles-Medranda Carlos , Valero Manuel , Soria-Alcívar Miguel , Puga-Tejada Miguel , Oleas Roberto , Ospina Jesenia , Alvarado-Escobar Haydee , Baquerizo-Burgos Jorge , Pitanga-Lukashok Hannah 
Published: July 2019

Abstract
Background and study aims The aim of this study was to evaluate the diagnostic yield of endoscopy using optical enhancement (OE system) with optical magnification to predict reflux in non-erosive reflux disease (NERD) patients.
Patients and methods A prospective, non-randomized, single-blind study was performed from September 2015 to January 2016. Participants suffered from gastroesophageal reflux disease (GERD) symptoms and were assigned to the NERD group or the non-reflux disease control group based on endoscopic findings and a 24-hour pH-impedance-monitoring test. Endoscopy using the OE system with optical magnification was performed in all patients to detect minimal mucosal esophageal lesions (MMEL), specifically abnormalities in the numbers, dilation, and tortuosity of intrapapillary capillary loops (IPCLs). Biopsies were obtained from each esophageal segment, and diagnoses from images were compared to diagnoses of reflux and inflammation using 24-hour pH-impedance monitoring and histology, respectively.
Results Fifty-seven patients were included (36 in the NERD group, 21 in the control group). IPCLs were observed in 94.4 % of cases in the NERD group and 38 % of cases in the control group (P  < 0.05). There were significant differences in IPCL abnormalities between groups that were associated with histologically identified inflammation. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 94.4 %, 61.9 %, 80.9 %, 86.6 %, and 82.4 %, respectively. The 24-hour pH-impedance-monitoring test was used as the gold standard. The Kappa interobserver and intraobserver values were 0.85 and 0.90, respectively.
Conclusion The OE system with optical magnification can detect MMEL and predict NERD with high sensitivity, accuracy, and interobserver and intraobserver agreement. Presence of IPCLs highly correlates with histologically identified inflammation.
Improvement in Glycemic Control in Mice of Different Age Groups
Authors: Gamage Suhadinie , Peddibhotla Swetha , Reddy P. Hemachandra , Dhurandhar Nikhil V. , Hegde Vijay 
Published: July 2019

Abstract
Aims and Methods The declining ability to control blood glucose with advancement of age is an important health risk factor and may lead to insulin resistance, type-2-diabetes and Alzheimer’s disease. Adenovirus 36(Ad36) improves glycemic control independent of insulin signaling(insulin sparing effect) as evidenced by cell, animal and observational human studies. This property of Ad36 may be useful in correcting aging-related glucose intolerance and related health conditions. Therefore, we determined the effect of Ad36 on glycemic control in older mice, to identify the age group that best responds to Ad36. Six, 12 or 20-month old C57Bl/6 mice on chow diet were each divided into weight-matched groups(mock-infected or Ad36-infected). Body weight was recorded weekly post infection (p.i.) and fasting glucose measured(week 0, 4, 8 and 20 p.i.). Blood glucose and serum insulin were measured during glucose tolerance test(week 0 and 16 p.i.). At week 20 p.i., animals were sacrificed, blood and tissues collected.
Results Mice from all age groups showed improvement in glucose clearance post Ad36 infection, but a more profound effect was observed in 6-month old mice compared with mock-infected mice. Under fed conditions though there was no difference in blood glucose at 20 wk p.i., interestingly, Ad36 reduced serum insulin in age groups old mice, compared with control mice.
Conclusions These findings suggest Ad36 infected animals improve glycemic control and clear post-prandial gluco00000se increase without increasing insulin secretion in an insulin sparing manner. These beneficial effects provide strong evidence for developing Ad36-based approaches as a novel tool to attenuate age associated glucose intolerance.
Genetische Untersuchungen bei Kindern und Jugendlichen mit Entwicklungsstörung, Behinderung und Epilepsien – was erwarten Eltern von der Aufklärung
Authors: Mey Marie , Jenke Andreas C.W. , Borusiak Peter 
Published: July 2019

Zusammenfassung
Hintergrund Die informierte Zustimmung des Patienten bzw. seiner Sorgeberechtigten ist unabdingbare Voraussetzung für genetische Diagnostik. Die Aufklärung über derartige genetische Diagnostik stellt den beratenden Arzt vor besondere Herausforderungen bzgl. laienverständlicher Vermittlung komplexer Zusammenhänge, Empathie in die Situation der Familie, Berücksichtigung des elterlichen Rechtes auf Wissen ebenso wie auf Nichtwissen. Die Erwartungen von Eltern an eine solche Aufklärung sind bisher allerdings kaum untersucht.
Methode In einem stufenweisen Vorgehen wurden zunächst freie Interviews mit 5 Elternpaaren geführt, auf deren Basis ein halbstandardisierter Fragebogen entwickelt wurde. Dieser wurde dann in einer Befragung von 30 Eltern von Kindern mit Intelligenzminderung, Autismus und/oder Epilepsien, bei denen eine molekulargenetische Untersuchung in der Vergangenheit durchgeführt wurde, eingesetzt.
Ergebnisse Die Aufklärungsgespräche bedeuten für die Eltern eine Herausforderung und emotionale Anspannung. Einen hohen Stellenwert haben hier v. a. die Bereiche „Diagnose“ und „Therapie“. Die Eigeneinschätzung der Vorkenntnisse ist sehr unterschiedlich, wobei viele Eltern Verständnisprobleme im Gespräch angaben. Überwiegend als „sehr wichtig“ oder „wichtig“ wurden folgende Themenbereiche eingeordnet: Befunde unklarer Zuordnung bzgl. der Pathogenität, Zufallsbefunde, Recht auf Nichtwissen, psychische Folgen, weiterer Verlauf, mögliche Therapien. 10 Eltern hatten entweder keinen oder einen Sonderschulabschluss, 20 Eltern waren im Deutschen Nichtmuttersprachler.
Diskussion Eltern haben einen hohen Informationsbedarf, der fast alle Bereiche der Aufklärung umfasst. Kommunikative Hürden erschweren auch aus Elternsicht die Aufklärung. Hier besteht klares Verbesserungspotenzial. Internet-basierte Angebote in mehreren Sprachen und in leichter Sprache könnten eine Hilfestellung bieten.
Der Einfluss der Alltagsrelevanz von
APHABu-Fragen auf deren Beantwortung
Authors: Storz Stephanie , Wollenberg Barbara , Schönweiler Rainer , Löhler Jan 
Published: July 2019

Zusammenfassung
Einleitung Der APHAB-Fragebogen ist eine Möglichkeit, das subjektive
Hörvermögen in verschiedenen Situationen zu ermitteln. Eine Voruntersuchung
zeigte, dass die APHAB-Fragen eine unterschiedliche Relevanz im Alltag der
Befragten haben. Mit dieser Studie sollte ermittelt werden, ob die
Alltagsrelevanz der einzelnen APHAB-Fragen auch einen Einfluss auf die Bewertung
der Fragen hat.
Methoden Von Juni 2017 bis November 2017 wurde bei 517 schwerhörenden
Probanden aus 11 verschiedenen HNO-Praxen in Schleswig-Holstein im Rahmen der
Befragung mittels des APHAB-Fragebogens parallel die Alltagsrelevanz der
einzelnen Fragen für die Befragten auf einer weiteren, vierstufigen Antwortskala
(häufig – manchmal – selten – nie) ermittelt. Die Antworten wurden in einer
Kreuztabelle den APHAB-Fragen zugeordnet und mittels
Kreuztabellen/χ2-Test und Cramérs V als Zusammenhangsmaß
ausgewertet.
Ergebnisse Der Mittelwert des Probandenalters lag bei 67,4 Jahren
(± 14,0 Jahre); 45,3 % der Teilnehmer waren weiblichen, 54,7 % männlichen
Geschlechts. Vier Fragen der EC-Subskala, drei der BN-Skala und zwei der
RV-Skala wiesen einen mittleren Zusammenhang zwischen der Alltagsrelevanz und
der APHAB-Bewertung auf, hinsichtlich eines schwachen Zusammenhangs ist es genau
umgekehrt. Eine besondere Häufung hinsichtlich der mit einem schwachen
Zusammenhang bewerteten findet sich bei allen invers formulierten APHAB-Fragen
(p < 0,001).
Diskussion Es ließ sich nachweisen, dass ein Zusammenhang zwischen der
Alltagsrelevanz der APHAB-Frage und ihrer Beantwortung besteht, allerdings
unterschiedlich ausgeprägt für die einzelnen Fragen. Insgesamt ist dieser
Zusammenhang bei der einen Hälfte der APHAB-Fragen in einem schwachen, bei der
anderen Hälfte in einem mittleren Ausmaß vorhanden (Cramérs V). Die Gründe
hierfür sind unklar und bedürfen einer weiteren Untersuchung.
The Petroclinoid Ligament: Its Morphometrics, Relationships, Variations, and Suggestion for New Terminology
Authors: Iwanaga Joe , Altafulla Juan J. , Gutierrez Santiago , Dupont Graham , Watanabe Koichi , Litvack Zachary , Tubbs R. Shane 
Published: July 2019

AbstractThe anatomy and definition of the petroclinoid ligament (PCL) and its relationship with the abducens nerve are variably described. The goal of this study was to clarify the anatomy of the PCL and better elucidate its relationship with the abducens nerve. Thirty-six sides from 18 fresh-frozen adult cadaveric heads were used in this study. Specimens were all Caucasian and derived from 10 males and 8 females. The mean age at death was 79 years. Dissection of the PCL and abducens nerve was performed using a surgical microscope. The anterior and posterior attachments of the PCL, and position of the abducens nerve were noted. Subsequently, the width, thickness, and length of the ligament, and diameter of the abducens nerve were measured. Thirty-one sides (86.1%) were found to have a PCL, on two sides (5.6%), the PCL was ossified, and on three sides (8.3%), the PCL was absent. The width, thickness, and length of the PCL ranged from 0.54 to 3.39, 0.07 to 0.49, and 3.27 to 17.85 mm, respectively. No PCL had an anterior attachment onto the posterior clinoid process but rather, the clivus. Therefore, based on our findings, the PCL would be better described as the petroclival ligament.
Knowledge of Pregnant Women about Pregnancy Gingivitis and Children Oral Health
Authors: Togoo Rafi A. , Al-Almai Balsam , Al-Hamdi Fatimah , Huaylah Salha H. , Althobati Mashael , Alqarni Safeyah 
Published: July 2019

Abstract
Objective A cross-sectional questionnaire-based study was carried out among 251 pregnant women to assess their level of knowledge and perception regarding pregnancy gingivitis and the oral health of new born children.
Materials and Methods A self-administered validated questionnaire was distributed among pregnant women visiting the Child and Maternity Hospital, Ministry of Health, Aseer, Saudi Arabia. The questionnaire included the questions related to their knowledge/awareness about cause, treatment, preventive measures, and the adverse effects of gingivitis on oral health of a woman.
Statistical Analysis The data was entered into Microsoft excel sheet and put to statistical analysis using SPSS (version 17). Descriptive analysis and also chi-squared test was used for comparison.
Results Majority of pregnant women were found unaware about developing of pregnancy gingivitis as well as the cause, effects, treatment, and preventive measures for the same. Most of the subjects agreed that it was essentially required to have oral health education before their pregnancy term would start.
Conclusion Most of the pregnant women said that they were unaware about pregnancy gingivitis, though few reported of being aware about it. It is inferred that the collaborative efforts between general dentists, pediatric dentists, public health dentists, and medical professionals are needed to raise awareness among pregnant women regarding timely dental care to avoid the adverse pregnancy related outcomes due to gingivitis and periodontitis.
Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network
Authors: Cagnan Hayriye , Mallet Nicolas , Moll Christian K. E. , Gulberti Alessandro , Holt Abbey B. , Westphal Manfred , Gerloff Christian , Engel Andreas K. , Hamel Wolfgang , Magill Peter J. , Brown Peter , Sharott Andrew 
Published: July 2019

Significance
Prevalence and temporal dynamics of transient oscillations in the beta frequency band (15 to 35 Hz), referred to as β bursts, are correlated with motor performance. Disturbance of these activities is a candidate mechanism for motor impairment in Parkinson’s disease (PD), where the excessively long bursts correlate with symptom severity and are reduced by pharmacological and surgical treatments. Here we describe the changes in action potential firing that take place across multiple nodes of the cortical and basal ganglia circuit as these transient oscillations evolve. These analyses provide fresh insights into the network dynamics of β bursts that can guide novel strategies to interfere with their generation and maintenance in PD.
Intrinsic expression of viperin regulates thermogenesis in adipose tissues
Authors: Eom John , Kim Jeong Jin , Yoon Seul Gi , Jeong Haengdueng , Son Soojin , Lee Jae Bong , Yoo Jihye , Seo Hyun Ju , Cho Yejin , Kim Ku Sul , Choi Kyung Mi , Kim Il Yong , Lee Hui-Young , Nam Ki Taek , Cresswell Peter , Seong Je Kyung , Seo Jun-Young 
Published: July 2019

Significance
The expression of numerous interferon (IFN)-inducible proteins is triggered by IFN or stimuli that activate IFN signaling pathways in innate immune responses. However, many of these proteins are expressed without stimulation in specific tissues, suggesting that their intrinsic expression may have novel functions. We show here that viperin, an IFN-inducible protein, regulates fatty acid β-oxidation–mediated thermogenesis in adipose tissues. Viperin deficiency up-regulates the expression of thermogenesis- and fatty acid β-oxidation–related genes, which in turn increases heat production, reduces fat mass, improves high-fat diet–induced glucose tolerance, and enhances cold tolerance. Thus, the intrinsic expression of viperin plays a novel, pivotal role in thermoregulation.
Exploring the learning potential of models with secondary school EFL
learners
Authors: Montealegre Ramón Félix 
Published: July 2019

Abstract
The role of Corrective Feedback (CF) in the process of acquiring
a second language (L2) has been deemed an issue of controversy among theorists
and researchers alike. In this empirical study, the objective is to investigate
the quality of EFL learners’ processing of feedback employing models and
different types of noticing (perfunctory or substantive [Qi & Lapkin, 2001]). The study was carried out with
13- and 14-year-old learners placed in two groups and engaged in a three-stage
writing task that included composing a picture-based story (Stage 1), comparing
their texts with a model (Stage 2), and rewriting the story (Stage 3). The
groups differed in the way they were prompted to process the model text. The
findings indicate that there are no differences between the two feedback groups
within stages. All the participants increased the number of features reported
across stages regardless of the feedback condition. The employment of a model
text provided the students with alternative features related to lexis, form, and
ideas. The potential effects of model texts and types of noticing on L2
learners’ language development are discussed.
Using learner corpus methods in L2 acquisition
research
Authors: Lozano Cristóbal , Díaz-Negrillo Ana 
Published: July 2019

Abstract
Since the 1970s, findings from Morpheme Order Studies (MOS) have
suggested that the emergence of morphemes follows a predictable order in L2
English. In this paper we show how the tools and practices in Learner Corpus
Research (LCR) offer a richer descriptive basis, which is achieved with
Interlanguage Annotation (ILA), a manual, fined-grained, purpose-oriented type
of annotation. Additionally, we use a standardised placement test, since
proficiency level has been overlooked in most previous MOS. Both of these
practices provide a more detailed description of morpheme accuracy order across
different levels. We analyse four proficiency levels (A1-B2) in a subcorpus of
L1 Spanish-L2 English secondary-school learners from the CORpus of English as a
Foreign Language (COREFL). Our results partially confirm findings from previous
MOS, but also reveal key findings that had gone previously unnoticed regarding
the role of proficiency level and the subtype of errors, which are relevant
factors for SLA research.
Quantity of target language contact in study abroad and knowledge of multiword expressions
Authors: Arvidsson Klara 
Published: July 2019

AbstractThis study takes a Usage-Based approach to the learning of French multiword expressions (MWEs) in Study Abroad (SA). MWEs are conventionalized form-meaning mappings, for exampledu coup(‘and so’) anden fait(‘actually’), and are assumed to be learned through repeated exposure. Based on this assumption, the study adopted a pretest/posttest design to explore how quantity of out-of-class target-language (TL) contact predicted the development of MWE knowledge among 41 Swedish students during a semester in France. MWE knowledge was assessed by a modified cloze test based on transcriptions of informal language use (www.clapi.fr) and TL contact information was obtained through the Language Engagement Questionnaire (McManus, Mitchell, & Tracy-Ventura, 2014). Contrary to expectations, the findings showed that quantity of out-of-class TL contact did not predict gains in MWE knowledge and add further counterevidence for the role of sheer quantity of TL contact for linguistic development in SA.