bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biosorption potential of two brown seaweeds in the removal of chromium
Authors: Yalçın Sibel , Özyürek Mustafa 
Published: January 2019

Abstract
The present work focused on the potential use of brown algae Cystoseira barbata and Cystoseira crinita from the Black Sea coast for removal and speciation analyses of Cr(III,VI) ions from aqueous and wastewater solutions. The biosorption process of Cr(III) and Cr(VI) was designed as a function of pH and contact time. Potentiometric titration and Fourier transform infrared spectroscopy (FT-IR) analysis techniques revealed the potential binding sites present at the surface of the algae for both oxidation states of Cr. Various chemical treatments have been used to indicate the mechanisms of binding Cr(III,VI) and bioreduction of Cr(VI) by the biosorbents. Acidic treatment was the most successful in removing and reducing total Cr(VI). Algae samples were subjected to methylation and esterification processes for modification of amino and carboxyl groups, respectively. The Langmuir model was applied to describe the biosorption of Cr(III,VI) by algae. Total Cr and Cr(VI) determinations were simultaneously made using the diphenyl carbazide spectrophotometric method and flame atomic absorption spectroscopy (FAAS). In conclusion, these algae can be used as a potentially cost-effective biosorbent for the uptake of two different oxidation states of Cr and subsequently for Cr speciation analysis.
Structure-Activity Relationships of Cytotoxic Lactones as Inhibitors and Mechanisms of Action
Authors: Torrens Francisco , Castellano Gloria 
Published: January 2019

Background:
Some lactones prevent protein Myb-dependent gene expression.

Objective:
The object is to calculate inhibitors of Myb-brought genetic manifestation.

Methods:
Linear quantitative structure–potency relations result expanded, among sesquiterpene lactones
of a variety of macrocycles (pseudoguaianolides, guaianolides, eudesmanolides and germacranolides), to
establish which part of the molecule constitutes their pharmacophore, and predict their inhibitory potency
on Myb-reliant genetic manifestation, which may result helpful as leads for antileukaemic therapies with a
new mechanism of action.

Results:
Several count indices are connected with structure–activity. The α-methylene-γ-lactone ML functional
groups increase, whereas OH groups decrease the activity. Hydrophobicity provides to increase cell
toxicity. Four counts (ML, number of α, β-unsaturated CO groups, etc.), connected with the number of
oxygens, present a positive association, owing to the partial negative charge of oxygen. The s-trans-strans-
germacranolide molecule presents maximal potency. The OH groups decrease the potency owing to
the positive charge of hydrogen. The numbers of π-systems and atoms, and polarizability increase the potency.
Following least squares, every standard error of the coefficients is satisfactory in every expression.
The most predictive linear expressions for lactones, pseudoguaianolides and germacranolides are corroborated
by leave-group-out cross-validation. Quadratic equations do not make the correlation better.

Conclusion:
Likely action mechanisms for lactones are argued with a diversity of functional groups in the
lactone annulus, including artemisinin with its uncommon macrocycle characteristic, 1,2,4-trioxane cycle
(pharmacophoric peroxide linkage -O1-O2- in endoperoxide ring), which results in the foundation for its
sole antimalarial potency.
Multi-parametric MR Imaging Biomarkers Associated to Clinical Outcomes in Gliomas: A Systematic Review
Authors: Oltra-Sastre Miquel , Fuster-Garcia Elies , Juan-Albarracin Javier , Sáez Carlos , Perez-Girbes Alexandre , Sanz-Requena Roberto , Revert-Ventura Antonio , Mocholi Antonio , Urchueguia Javier , Hervas Antonio , Reynes Gaspar , Font-de-Mora Jaime , Muñoz-Langa Jose , Botella Carlos , Aparici Fernando , Marti-Bonmati Luis , Garcia-Gomez Juan M. 
Published: January 2019

Purpose:
To systematically review evidence regarding the association of multiparametric
biomarkers with clinical outcomes and their capacity to explain relevant subcompartments
of gliomas.

Materials and Methods:
Scopus database was searched for original journal papers from January
1st, 2007 to February 20th, 2017 according to PRISMA. Four hundred forty-nine abstracts of papers
were reviewed and scored independently by two out of six authors. Based on those papers we
analyzed associations between biomarkers, subcompartments within the tumor lesion, and clinical
outcomes. From all the articles analyzed, the twenty-seven papers with the highest scores were
highlighted to represent the evidence about MR imaging biomarkers associated with clinical outcomes.
Similarly, eighteen studies defining subcompartments within the tumor region were also
highlighted to represent the evidence of MR imaging biomarkers. Their reports were critically appraised
according to the QUADAS-2 criteria.

Results:
It has been demonstrated that multi-parametric biomarkers are prepared for surrogating
diagnosis, grading, segmentation, overall survival, progression-free survival, recurrence, molecular
profiling and response to treatment in gliomas. Quantifications and radiomics features obtained
from morphological exams (T1, T2, FLAIR, T1c), PWI (including DSC and DCE), diffusion
(DWI, DTI) and chemical shift imaging (CSI) are the preferred MR biomarkers associated to
clinical outcomes. Subcompartments relative to the peritumoral region, invasion, infiltration, proliferation,
mass effect and pseudo flush, relapse compartments, gross tumor volumes, and highrisk
regions have been defined to characterize the heterogeneity. For the majority of pairwise cooccurrences,
we found no evidence to assert that observed co-occurrences were significantly different
from their expected co-occurrences (Binomial test with False Discovery Rate correction,
α=0.05). The co-occurrence among terms in the studied papers was found to be driven by their individual
prevalence and trends in the literature.

Conclusion:
Combinations of MR imaging biomarkers from morphological, PWI, DWI and CSI
exams have demonstrated their capability to predict clinical outcomes in different management
moments of gliomas. Whereas morphologic-derived compartments have been mostly studied during
the last ten years, new multi-parametric MRI approaches have also been proposed to discover
specific subcompartments of the tumors. MR biomarkers from those subcompartments show the
local behavior within the heterogeneous tumor and may quantify the prognosis and response to
treatment of gliomas.
Impact of Hybrid-polar Histone Deacetylase Inhibitor m-Carboxycinnamic Acid bis-Hydroxyamide on Human Pancreatic Adenocarcinoma Cells
Authors: Kumar Dinesh , Sarma Pranjal , Bhadra Manika P. , Tangutur Anjana D. 
Published: January 2019

Background:
Histone deacetylase inhibitors (HDACIs) have got immense importance as promising
drugs for cancer treatment as these inhibitors regulate cellular differentiation, gene expression, cell cycle arrest
and apoptosis. The current study investigates the effect of the hybrid-polar HDACI m-carboxycinnamic acid bishydroxyamide
(CBHA) on the growth of human pancreatic adenocarcinoma cells, using the cell line MIA PaCa-
2 as an in vitro model.

Methods:
Following CBHA treatment of the MIA PaCa-2 cells, we characterized the effect of CBHA by in vitro
cytotoxicity evaluation, clonogenic assay, cell cycle analysis, immunoblotting for soluble and insoluble fractions
of tubulin, immunofluorescence and caspase-3 assay.

Results:
We observed that the histone deacetylase inhibitor CBHA markedly impaired growth of the pancreatic
cancer cells by resulting in dose-dependent G2/M arrest, disruption of microtubule organization, induction of
caspase-mediated apoptosis and in vitro suppression of HDAC6. Our study also shows that inhibition of
HDAC6 by CBHA induced acetylation of α-tubulin.

Conclusion:
Together, our findings show that CBHA can be a potential plausible therapeutic that could be
exploited for pancreatic cancer therapy.
The Potential Implication of FTO rs17817449 Gene Polymorphism on BMI Mediated Risk For Type2 Diabetes Among Obese Egyptian Children And Adolescents
Authors: Barseem Naglaa Fathy , El Ella Soheir S. Abou , Tawfik Maha A. , El-Nehrawy Rasha R. 
Published: January 2019

Background:
Genetic variations of the FTO gene were associated with obesity and type 2
diabetes determinants in the European population, notably raised blood levels of insulin and glucose.

Objective:
The aim of this study was to test the association of FTOrs17817449 with obesity/BMI and
type 2 diabetes risk among obese Egyptian population.

Materials and Methods:
In this case-control study, (PCR-RFLP assay) was used for genotyping
FTOrs17817449polymorphism (SNP) in 120 obese children and 120 controls conducted from attendants
of genetic & endocrinology Unit and outpatient clinics, Pediatric Department, Faculty of Medicine,
Menoufia University Hospitals. In combination with anthropometric measurements of obesity,
predisposition to T2D risk was analyzed (fasting insulin, fasting glucose, insulin resistance).

Results:
Consanguinity was evident in 32.5% of cases. Positive family history of both obesity and T2D
was found to be significant statistically (p<0.05). FTO rs17817449G allele was positively associated
with WC (Waist Circumference) (Mean ± SD 84.1 ± 9. 3), raised BMI (Body Mass Index) (32.7 ± 3.5),
fasting glucose (114.1 ± 12.8mg/dl), fasting insulin (7.2 ± 1.2µU/ml) and insulin resistance (61.1% of
cases) (p<0.001).

:
The odds ratio of obesity was 1.75(95%CI 1.02-3.02) for GT and GG genotype. Fasting glucose and
fasting insulin showed statistically significant risk for T2D in the obese group.

Conclusion:
Genetic variation in FTOrs17817449(G allele) was definitely associated with raised BMI,
BMI z-score and fasting insulin, and lowered QUICKI values, that predicted the risk for type 2 diabetes
among obese children harboring the mutant G allele.
AUDIENCE AND PUBLIC SERVICE ADVERTISEMENT ABOUT THE DANGERS OF SMOKING
Authors: Akalili Awanis 
Published: January 2019

Public service advertisement which said “Berhentilah Menikmati Rokok Sebelum Rokok Menikmati Anda” is a warning the dangers of smoking which is aired on television. This advertisement is produced by the government to make smokers realize the dangers of smoking among young people especially students. However, this aim cannot be so easily achieved because the community nowadays is not a passive audience but it has moved into active audience. By taking four informants, this study tries to answer the question of how the student smokers among gang understand the advertising messages in public service advertisement which said “Berhentilah Menikmati Rokok Sebelum Rokok Menikmati Anda” on television. A reception analysis is chosen as the research method because this method can see how the audience understands the media messages based on the difference background they have. Based on the results of the study, it is found that four informants are able to negotiate with the advertising message on public service advertisement which said “Berhentilah Menikmati Rokok Sebelum Rokok Menikmati Anda”. The four informants are able to understand the messages from that advertising by using their own point of view. The difference of meaning is affected by two things: the family environment and the existence as a gang member. Two informants receive the advertisement, while two other informants assume that the public service advertisement does not correspond to the reality. AUDIENS DAN IKLAN LAYANAN MASYARAKAT TENTANG BAHAYA MEROKOKklan layanan masyarakat “Berhentilah Menikmati Rokok Sebelum Rokok Menikmati Anda” adalah peringatan bahaya merokok yang ditayangkan melalui televisi. Iklan ini diproduksi pemerintah dengan tujuan menyadarkan para perokok akan bahaya merokok, terutama kaum muda khususnya para pelajar. Hanya saja tujuan tersebut tidak bisa semudah itu dicapai karena saat ini masyarakat bukan kelompok penonton pasif tetapi sudah bergerak sebagai audiens aktif. Dengan mengambil empat informan, penelitian ini mencoba menjawab pertanyaan tentang bagaimana pelajar perokok di lingkungan geng meresepsi pesan iklan dalam iklan layanan masyarakat “Berhentilah Menikmati Rokok Sebelum Rokok Menikmati Anda” di media televisi. Analisis resepsi sendiri dipilih sebagai metode penelitian karena metode ini melihat bagaimana audiens memahami pesan media berdasarkan perbedaan latar belakang yang dimiliki. Berdasar dari hasil penelitian, ditemukan fakta bahwa keempat informan mampu bernegosiasi dengan pesan iklan pada tayangan iklan layanan masyarakat “Berhentilah Menikmati Rokok Sebelum Rokok Menikmati Anda”. Keempat informan mampu memahami pesan iklan yang disampaikan dengan sudut pandang mereka masing-masing. Perbedaan pemaknaan ini dipengaruhi oleh dua hal yaitu lingkungan keluarga dan keberadaan sebagai anggota geng. Dua informan menerima wacana yang di sampaikan, sementara dua informan lainnya menganggap tayangan iklan layanan masyarakat tersebut tidak sesuai dengan realitas.
Pengaruh Variasi Ukuran Butiran Pasir Merah Labuhan Batu Selatan Untuk Meningkatkan Kekuatan Beton
Authors: Lubis Fadilah Ulfa , Harahap Mukti Hamjah 
Published: January 2019

ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh penambahan pasir merah ukuran 80 mesh, 100 mesh, dan 120 mesh terhadap nilai kuat tekan dan daya serap air beton. Metode pembuatan yang dilakukan adalah SNI 03-2834-2000 yang mengacu pada pembuatan beton mutu K-175 dengan komposisi campuran semen : pasir : kerikil adalah 1 : 2 : 3 dengan FAS 0,5. Beton dibuat berbentuk kubus 15 x 15 x 15 cm. Pada penelitian ini dibuat variasi komposisi pasir merah sebesar 80 mesh, 100 mesh, dan 120 mesh. Setelah beton berumur 24 jam cetakan dibuka dan diberi nomor kode sesuai yang diinginkan dan dirawat dalam bak air. Setelah melalui masa perendaman 28 hari kemudian beton diuji dengan metode uji kuat tekan dan daya serap air. Dari hasil pengujian diperoleh sifat mekanik yaitu kuat tekan beton minimumnya yaitu pada penambahan pasir merah 120 mesh yaitu rata-rata 13.36 MPa, sedangkan kuat tekan beton maksimum pada penambahan pasir merah 80 mesh yaitu rata-rata 15,61 MPa. Dari hasil pengujian daya serap air terjadi penurunan pada beton dengan penambahan pasir merah pada ukuran 80 mesh (sampel B) dan 120 mesh (sampel D) yaitu 50%. Hal ini dapat disimpulkan bahwa variasi ukuran butir lebih efektif untuk menurunkan daya serap air.Kata kunci : Pasir merah 80 mesh, Pasir Merah 100 mesh, Pasir Merah 120 mesh, Kuat Tekan, Daya Serap Air
RECIA y su primer decenio. Una realidad que nos convoca
Authors: De La Ossa V Jaime , Montes-Vergara Donicer , Pérez-Cordero Alexander 
Published: January 2019

Hace diez años, con la alegría que producen las buenas intenciones, dábamos inicio a la vida pública de la Revista Colombiana de Ciencia Animal – RECIA, decíamos: <<Bienvenidos a este espacio de divulgación creado para los científicos, profesionales, técnicos, estudiantes, pensadores e interesados en la Ciencia Animal; bienvenidos todos independientemente de su nacionalidad, regionalidad, idioma o acento; extendemos una mano amplia, amiga y críticamente respetuosa en bien del crecimiento intelectual y de la sociedad en su conjunto. Seguir la huellas con el debido respeto, valorar la dignidad y sueños de quienes erigieron esta cultura, de quienes creyeron en ella y entregaron su vida o parte de ella para que hoy sea cierto lo que nos identifica como pueblo, es una meta que debemos orientar desde diferentes ángulos y la producción científica debe ser el eje principal desde donde proyectemos nuestros ideales de bienestar y desarrollo, desde el poblado, pasando por la nación para abrazar el mundo. La Revista Colombiana de Ciencia Animal de la Facultad de Ciencias Agropecuarias de la Universidad de Sucre nace como escenario intelectual nacional e internacional, que brinda cálida acogida a quienes con su intelecto ayudan a formar el mundo desde los sueños hasta la conclusión real>>
Context-oriented Knowledge Management in Production Networks
Authors: Sandkuhl Kurt , Smirnov Alexander 
Published: January 2019

Abstract
Production networks have been established in many industrial domains with globalized supply structures, sourcing strategies or cooperation environments. Knowledge management in such networks requires a context-oriented approach in order to accommodate for individual and organizational needs when providing relevant knowledge for complex tasks, such as value creation. The focus of this paper is on the procedure by which to determine what actually has to be taken into account as part of the ‘context’ for establishing context-oriented knowledge management, how to capture this context, and how to use it. The variability of organisational and individual tasks both at design time and at runtime is essential for understanding context in production networks. The main contribution of the present study is a context modelling method, including variability identification. The application of this method is demonstrated by using an example of a production network from automotive industries.
Geometry of Mus-Sasaki metric
Authors: Zagane Abderrahim , Djaa Mustapha 
Published: January 2019

Abstract
In this paper, we introduce the Mus-Sasaki metric on the tangent bundle T M as a new natural metric non-rigid on T M. First we investigate the geometry of the Mus-Sasakian metrics and we characterize the sectional curvature and the scalar curvature.
University’s Social Responsibility – Labor Market Perspective
Authors: Buchta Krystyna , Jakubiak Monika , Skiert Małgorzata , Wilczewski Adam 
Published: January 2019

Abstract
Changes in the socio-economic environment of universities require its tasks and social roles to be constantly reviewed and redefined. The present paper attempts to assess universities’ responsibility for the outcomes of educational process. The outcomes are measured on the basis of graduates’ preparedness for undertaking professional work. The paper’s aim was to indicate the main discrepancies between employers’ expectations regarding graduates’ occupational training and the level of competences acquired by graduates in the course of their studies. A premise was made that the comparison of the views presented by the main stakeholders will enable the level on which the individual competences match the needs of labor market to be determined, and the strengths and weaknesses of university curricula to be indicated. The analysis encompassed both hard occupational skills, which are subordinated to the content-related educational profile, and key soft competences.
Neural Network Application to Support Regression Model in Forecasting Single-Sectional Demand for Telecommunications Services
Authors: Kaczmarczyk Paweł 
Published: January 2019

Abstract
The aim of this research study is to test the effectiveness of the single-sectional integrated model, in which a neural network is applied to support a regression, as a consistent tool for short-term forecasting of hourly demand (in sec.) for telecommunications services. The theoretical part of the paper involves the idea of the single-sectional integrated model and differences between this model and a multi-sectional integrated model. Moreover, the research methodology is described, i.e. the elements used in the constructed model (the feedforward neural model and the regression with dichotomous explanatory variables), and the manner of their integration are discussed.
In the empirical part of this work, the results of the carried out experiments are included. The comparison of the obtained effectiveness (in terms of approximation and prediction) of the explored single-sectional integrated model with the effectiveness of the non-supported regression model and the multi-sectional integrated model are conducted. In this research work, it is proved that the single-sectional integrated model enables better results in comparison to the non-integrated regression and the mutli-sectional integrated model. The originality of this paper is based on: the created single-sectional integrated model in terms of the analysed phenomenon, the verification of the model effectiveness, and the comparison of the constructed model with other models and assessment.
Prevalence of Metabolic Syndrome and of Cardiovascular Risk Factors
Authors: Andrei Manta , Alexandra Maștaleru , Andra Oancea , Constantin Anghel Razvan , Mihai Roca , Magdalena Leon-Constantin Maria , Florin Mitu 
Published: January 2019

Abstract
Obesity, a component of the metabolic syndrome, is a rising public health problem, continuously increasing in the European countries. The therapeutic success of the patient with metabolic syndrome requires a multidisciplinary approach to lifestyle changes, weight loss, continuous and dynamic dietary improvement, sedentary reduction, normalization of blood pressure, glycemia and lipid parameters. We performed a retrospective study that was conducted in the Clinical Rehabilitation Hospital in Iasi, with 4627 patients that were admitted in the Cardiovascular Rehabilitation Clinic from January 2011 to December 2015 with the diagnosis of metabolic syndrome according to WHO definition (Group 1) or with other comorbidities (Group 2). In the first group were included 1064 patients diagnosed with metabolic syndrome. This group has predominantly smoking female patients. Also, in group 1 were diagnosed more patients with left ventricular hypertrophy and coronary heart disease compared to group 2. Most of the patients with inflammatory syndrome were included in the group without metabolic syndrome (group 2). The results of our study confirm that metabolic syndrome is a cluster of abnormalities whose evolution determines the development of coronary heart disease. All this would advocate for treating metabolic syndrome as the primary method of preventing cardiovascular disease.
Implications of Diabetes Mellitus in Patients with Acute Coronary Syndromes - Poorer Outcomes Among Diabetics
Authors: Priscilla Pașc , Coţe Ioana Alexandra , Popescu Mircea Ioachim 
Published: January 2019

Abstract
Cardiovascular disease is the leading cause of death in the world, causing over 17 million deaths annually, of which 7.2 million by coronary heart disease. They are a major public health problem worldwide, of which acute coronary syndromes show special attention due to increased prevalence and incidence and poor prognosis. Although advanced therapies can improve the morbidity and mortality associated with acute coronary syndromes in well-developed countries, developing countries remain exposed to the ravages of these diseases. Of the patients admitted for acute coronary syndrome, about 30% suffer from diabetes mellitus, considered a major risk factor and a predictor for unfavorable evolution regardless of the type of acute coronary syndrome.
Application of the Barkhausen effect probe with adjustable magnetic field direction for stress state determination in the P91 steel pipe
Authors: Chmielewski Marek , Piotrowski Leszek 
Published: January 2019

Abstract
The paper presents the results of application of a novel Barkhausen effect (BE) probe with adjustable magnetizing field direction for the stress level evaluation in ferromagnetic materials. The investigated sample was in a form of a pipe, made of P91 steel that was anisotropic due to the production process. The measurements were performed before and after welding, revealing the influence of welding process on the residual stress distribution. As was observed, the process introduced high tensile stresses in the normal to the weld direction (which can be interpreted as a decrease of strongly compressive residual stresses present in martensitic steels). In addition to that, the paper presents investigations of the measurement set performance corroborating its applicability for Barkhausen effect signal measurements in the magnetically anisotropic materials. The signals obtained during manual rotation of the probe (typical method of BE measurements) are very similar to those recorded during automatic field axis rotation.