bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-in-human evaluation of the Cleveland Multiport Catheter for convection-enhanced delivery of topotecan in recurrent high-grade glioma: results of pilot trial 1
Authors: Vogelbaum Michael A. , Brewer Cathy , Barnett Gene H. , Mohammadi Alireza M. , Peereboom David M. , Ahluwalia Manmeet S. , Gao Shenqiang 
Published: April 2018

OBJECTIVEProgress in management of high-grade gliomas (HGGs) has been hampered by poor access of potential therapeutics to the CNS. The Cleveland Multiport Catheter (CMC), which deploys 4 independent delivery microcatheters, was developed to be a reliable, high-volume delivery device for delivery of therapeutic agents to the brain and other solid organs. The authors undertook this first-in-human clinical trial effort to evaluate the delivery characteristics of the CMC in patients with HGGs.METHODSA series of pilot studies were launched after approval of a sponsor-investigator IND (investigational new drug) application to evaluate the delivery of topotecan and gadolinium-DTPA (Gd-DTPA) via the CMC in patients with recurrent HGG. The first pilot trial evaluated delivery into enhancing tumor and nonenhancing, tumor-infiltrated brain. Two catheters were placed with the use of a conventional frameless stereotactic technique following a biopsy to confirm tumor recurrence, and drug infusion was performed both intraoperatively and postoperatively for a total of 96 hours with the same rate for all microcatheters. Delivery was assessed by intermittent MRI.RESULTSThree patients were enrolled in the first pilot study. MRI demonstrated delivery from all 6 catheters (24 microcatheters). The volume of distribution (Vd) of Gd-DTPA was heavily dependent upon CMC location (enhancing vs nonenhancing) with an approximately 10-fold difference in Vd observed (p = 0.005). There were no hemorrhages related to catheter placement or removal, and all 3 patients completed the protocol-defined treatment.CONCLUSIONSThe CMC is capable of providing backflow-resistant drug delivery to the brain and brain tumors. The volume of distribution is heavily dependent upon the integrity of the blood-brain barrier. Assessment of delivery is essential for development of loco-regionally applied therapeutics in the CNS.Clinical trial registration no.: NCT02278510 (clinicaltrials.gov)
Failure of facet replacement system with metal-on-metal bearing surface and subsequent discovery of cobalt allergy: report of 2 cases
Authors: Goodwin Matthew L. , Spiker William Ryan , Brodke Darrel S. , Lawrence Brandon D. 
Published: April 2018

The aim of this study was to report on 2 patients in whom metal-on-metal (MOM) facet replacements failed, with subsequent positive findings on allergy testing. Motion-preserving devices have been used with limited success when instrumentation is indicated in the mobile spine. MOM-bearing surfaces in orthopedics were developed to increase implant longevity, yet have been associated with numerous adverse outcomes, including local tissue reactions, pseudotumors, metallosis, and the need for revision surgery. Five patients with spinal stenosis and low-grade spondylolisthesis were randomized to undergo facet replacement surgery with the ACADIA facet replacement system at the authors’ institution. Two patients experienced a return of neurological symptoms after a pain-free interval (< 2 years) with development of local tissue reaction and positive findings on allergy testing to cobalt, the metal in the MOM-bearing surface. Both patients underwent successful removal of the implant and revision to titanium posterior spinal fusion and interbody fusion without further complication.Motion-preserving devices have been designed and trialed for specific indications in the mobile spine. Given the adverse results from MOM devices in hip arthroplasty and now the early reports with MOM facet replacements, caution is warranted when moving forward with any MOM joint–bearing surface. Both patients presented here had an unusual tissue reaction locally and subsequent positive allergy testing results to cobalt. These 2 patients appear to have developed a delayed hypersensitivity reaction to the metal, likely from fine debris at the MOM interface.
Associations of Angiotensin Converting Enzyme-1 and Angiotensin II Blood Levels and Cognitive Function
Authors: Yasar Sevil , Varma Vijay R. , Harris Gregory C. , Carlson Michelle C. 
Published: April 2018

Background: Emerging evidence suggests a possible role of the renin angiotensin system in the pathophysiologic process of Alzheimer’s disease, of which angiotensin converting enzyme-1 (ACE-1) and angiotensin II (ANGII) are important proteins. Few studies evaluated associations between blood ACE-1 and none between ANGII levels, and cognition. Objective: Our pilot study was aimed to examine associations between blood ACE-1 and ANG II levels and cognitive function in non-demented participants at baseline and over a 1-year period. Methods: 56 participants were included from the Brain Health Substudy of the Baltimore Experience Corps Study. Linear regression analysis, adjusting for confounders, was used to determine associations between baseline ACE-1 and ANGII, and baseline and 1-year follow-up measures of psychomotor and processing speed, executive function, verbal learning memory and working memory, and whether these associations were mediated by blood pressure. Results: Participants were predominantly female (75%), African-American (93%), with mean age of 67.8 years and education of 14.3 years. There were no associations between baseline ACE-1 or ANGII levels and cognitive function; however, there were significant association between baseline ACE-1 levels and 1-year follow-up Trail Making Test, Part A (β= 0.003, p = 0.04) and Digit Span (β= –0.001, p = 0.02). Conclusions: In this cognitively intact sample, elevated ACE-1 levels were associated with worse processing speed and working memory after 1 year. Findings from this pilot study suggest that changes in the RAS are associated with alterations in cognitive function warranting further assessment of the role of RAS in neurodegenerative disorders.
Diagnostic Accuracy of Combined Use of MCV and MCH for the Detection of Thalassaemia Carrier
Authors: Haque Nazmul , Hoque Sheikh Azimul , Islam Ariful , Chowdhury Yamin Shahriar , Debnath Bithi , Saha Narayan Chandra 
Published: April 2018

Background: Determination of thalassaemia carrier is the mainstay of prevention and in this context red cell indices like mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH) provide valuable tool for determination thalassaemia carrier.Objective: The purpose of the present study was to determine the diagnostic test validity of combined use of MCV and MCH for the determination of thalassaemia carrier.Methodology: This case-control study was carried out in the Department of Pediatrics and Department of Medicine at MAG Osmani Medical College Hospital, Sylhet, Bangladesh from September 2007 to January 2009 for a period of one year and five months. Siblings and cousins of beta thalassaemia major and haemoglobin-E (Hb-E) beta thalassaemia at any age with both sexes were selected for this study. Detailed history and thorough physical examination were performed meticulously. MCV, MCH and Hb-Electrophoresis were performed in all patients.Result: A total 128 siblings and cousins of beta thalassaemia major and Hb- E -beta thalassaemia were recruited for this study. Sensitivity, specificity, positive predictive value and negative predictive value of combine MCV & MCH in determination of thalassaemia carriers are 95.2%, 93.8%, 93.7% and 95.3% respectively.Conclusion: In conclusion combined use of MCV and MCH has high diagnostic validity for the detection of thalassaemia carrier.Journal of Current and Advance Medical Research 2017;4(2):40-43
Effect of weed control on the performance of transplant BRRI Dhan 32
Authors: Islam MS , Akter H , Aktar S , Miah J , Hossain SSF 
Published: April 2018

A field experiment was carried out at the Agronomy Field Laboratory, Bangladesh Agricultural University, Mymensingh during July to December 2003 to find out the effect of weed control on the performance of transplant Aman rice cv. BRRI Dhan 32. Weed control treatments Included in the study were no weeding, one hand weeding, two hand weeding, one hand weeding+one weeding with Japanese rice weeder, Rift@ 0.5, 0.75, 1.0, and 1.25 L ha-1 and Rostar@ 1.0, 1.5, 2.0, and 2.5 L ha-1. Important weed species found to infest the crop were Angta (Panicum repens), Acidgras (Ammania bacifera L.) Nackphulee (Cyperous difformis), Khudeshama (Echinochloa crusgalli) was the least important weed species. Higher doses of Rift 1.25L ha-1 and Ronstar 2.5 L ha-1 showed the best performance in reducing weed density and weed dry weight. The highest grain yield (5.0 4ton ha-1) was obtained from Ronstar 2.0 L ha-1 which was identical with the second highest grain yield (4.93 t ha-1) obtained from Rift 1.0 L ha-1. The highest net income of tk. 38915 ha-1 was obtained from Ronstar 2.0 L ha-1 and the next highest from Rift 1.0L ha-1.Progressive Agriculture 28 (4): 271-278, 2017
Influence of phytogenic feed additives and prebiotic in vegetable protein based diet on broiler performance
Authors: Tanzim HR , Das GB , Ahmad M , Barua M , Islam K 
Published: April 2018

This study was conducted to determine the effect of phytogenic feed additive and prebiotic on vegetable protein base diet in broiler performance. A total of 90 chicks (Cobb-500) were weighted and randomly assigned to the three treatment groups (To, T1 and T2) and supplemented with either phytogenic feed additives or prebiotic and reared for 28 days. Data on live body weight, body weight gain, feed intake and feed conversion (FC) were taken at weekly interval. Results revealed that significant (P<0.05) increase in live body weight of broilers was evident in both phytogenic feed additive and prebiotic supplemented groups comparing to the control group at 4th weeks of age. No significant (P>0.05) differences were found in live weight gain among the treatment groups on weekly intervals along the whole experimental period. However, significant differences (P<0.05) were evident on cumulative weight gain at 3rd and 4th weeks of age. In case of feed intake at the age of 3rd and 4th weeks, significant (P<0.05) differences were obtained with decreased feed intake in both phytogenic feed additive and prebiotic supplemented groups comparing to the control group. In case of feed conversion (FC), there were significant (P<0.05) differences among the groups on 1st week and 4th week of age. Best FC was accounted for prebiotic supplemented group along the whole experimental period. The survivability rates were 96.67%, 100% and 100% in control group, phytogenic feed additive and prebiotic supplemented group respectively. Results finally showed that vegetable protein when supplemented with phytogenic prebiotic feed additives and prebiotic c an additive beneficial effect on performance of when compared to non-supplemented control diet. So, ration using vegetable protein mixed with phytogenic feed additives or prebiotic can be recommended for broiler.Progressive Agriculture 28 (4): 323-330, 2017
"Recognizing limits "
Authors: Levinson Mark 
Published: April 2018

Je voudrais ici essayer de traiter le problème des limites d'expression dans une langue étrangère.
Diverses discussions avec des francophones et des anglophones bilingues, voire trilingues sont à l'origine de ces réflexions.
Après avoir remarqué que certaines personnes sont satisfaites et d' autres insatisfaites de leur niveau de langue, je suis arrivé à la conclusion que l'incapacité linguistique ne gênait ni l'expression ni la compréhension, mais que les blocages venaient de l'absence de pensées. Sans pensée, pas de langage.
Reconnaître les limites et les frontières déjà traversées, ou qui ne le sont pas encore, est donc essentiel pour le professeur et 1'étudiant.
Dans l'apprentissage d'une langue étrangère, la compréhension d'une idée précède son expression. Il doit donc y avoir des idées si l'on attend une expression dans une langue. C'est le rôle du professeur de faire penser et réfléchir ses étudiants pour qu'ils puissent exprimer ce qu'ils pensent - et ce, sans négliger de tenir compte de leurs limites.
Niveaux d'énonciation, niveaux de culture
Authors: Gallais-Hamonno Janine 
Published: April 2018

Dans chaque texte, peuvent être isolés quatre niveaux d'énonciation (langage, langue, discours scientifique et discours pédagogique). Toutefois, dans une communauté nationale, la culture scientifique, technique ou spécialisée des différents individus est différente. C'est pourquoi il faut distinguer, au sein d'une langue nationale, quatre niveaux de culture spécialisée (très spécialisée, spécialisée, cultivée, générale) dont chacune a un langage, une langue et des discours qui en un temps donné sont distincts les uns des autres.
Ce que l'on entend par "langues de spécialité" correspond aux niveaux "très spécialisé" et "spécialisé" des niveaux de culture. La "langue de communication" correspond aux deux autres niveaux de culture. Entre langues de spécialité et langue de communication existe ainsi une différence de niveau de spécialisation, mais il existe également une différence de nature qui fait de la langue de communication l'héritière de la langue de spécialité, après un délai plus ou moins long, mais avec parfois une perte de précision due au fait que la langue de communication se contente d'un à peu près, là où la langue de spécialité exige des traits explicités.
Comment faire parler les étudiants
Authors: Rinvolucri Mario 
Published: April 2018

How to make all the students speak.
The following text briefly describes several games useful for getting active oral participation from all the students in a group. It is not an article, since it contains no theoretical justification or analysis of the techniques used. The author has written a short description of the games that were presented at Sevres, 30 May 1985, at the annual congress of APLIUT, partly at a plenary session, then with a smaller workshop group.
L'E.A.O. à l'Université de Paris-Dauphine : Présentation du logiciel UNMASK
Authors: Rivas Michèle 
Published: April 2018

CALL at the Université Paris Dauphine - Presentation of UNMASK, a computer programme.
In 1985-86 we organised a CALL Seminar with John Higgins (see Cahiers de l'APLIUT n°21) and introduced the students to UNMASK, a computer programme for text-deletion /reconstruction created by M. François Rivas. Written for GOUPIL III (MSDOS 2.0) in MS Basic, UNMASK is equipped with an authoring system that enables teachers to enter their own specific texts (in management, economics, law, international conferences...). Three options are given for deletion, two for word reconstruction (full words or letter by letter) ; final scores are personalized, dated and timed ; 10 help pages are available.
Computer mediated discourse and student participation at Montpellier
Authors: Carter Locke 
Published: April 2018

Médiation informatique du discours et participation étudiante à Montpellier.
La communication informatique synchronique permet d'accroître la participation des élèves. Grâce à la médiation de la machine, et à un environnement de travail différent, ils peuvent communiquer collectivement sans être inhibés par le face à face du milieu scolaire traditionnel. L'article s'appuie sur une expérience menée à l'Université Paul Valéry de Montpellier avec des étudiants de deuxième année de DEUG d'anglais.
Essai de catégorisation sémantique des adjectifs composés (2)
Authors: Boughedaoui Mourad 
Published: April 2018

Attempt at a semantic categorization of compound adjectives (2)
This article follows the first part of the analysis of compound adjectives through a corpus of computer science texts. It deals with the ability of some linguistic units to combine with each other in order to generate three-and four-word compound adjectives. The study of this combinatory function has been carried out with the aim of clearing up the various generation mechanisms and the resulting semantic dynamics. From the pedagogic standpoint it allows isolating the main categories of compound adjectives to be integrated into the framework of an ESP course.
La traduction des poèmes : l’exemple du Romancero Gitano de Federico García Lorca
Authors: Gauthier Michel 
Published: April 2018

Translating poetry : Federico Garcia Lorca’s Romancero Gitano as a case in point
The translation of a poem is not faithful if it is a mere word for word translation. Transposing into the reader’s culture may amount to betrayal. The cultural, sociological, and psychogical roots of obscure poems, whose truth is hidden for various reasons (e. g., politics, modesty, etc.), should first be unveiled. The translator can only then try to be faithful to the unveiled meaning, and, possibly, to the metre of the target culture.
La simulation par le jeu de rôles comme méthode d'apprentissage de l'espagnol
Authors: Muñoz Jean 
Published: April 2018

La simulacion en actuaciones para aprender el español.
Dar clases de español de los principiantes hasta el nivel umbral del Consejo de Europa supone antes una reflexión para saber cuales serán las ayudas pedagógicas que se tendrán que utilizar para que los estudiantes consigan elevarse hasta las conversaciones corrientes y los intercambios complejos. Entre todos estos medios existe uno que résulta muy grato para el conjunto del grupo : el juego de roi o dramatización. ¿Qué es? ¿A quién se dirige ? ¿Cómo crear la dinámica de grupo para que resuite provechoso ? La dramatización será diferente segun el grupo en que se dan las clases. Será sencilla o con una estructura elaborada según el nivel de los estudiantes y pondrá en juego discusiones entre parejas, o juicios de tribunales donde el juez, los acusados y sus abogados pleitearán.
Les publications de François Jacob
Authors: Morange Michel 
Published: April 2018

François Jacob propuso con Jacques Monod, a comienzo de los años sesenta, el primer modelo de regulación de la actividad de los genes, llamado «modelo del operón». Este modelo suscitaría el reconocimiento internacional de la Escuela francesa de biología molecular y abriría la vía para el estudio de los organismos superiores y de su desarrollo embrionario. El estudio «genético» de la obra científica de François Jacob se ve dificultada por la pérdida de muchos documentos y por el hecho de que la mayor parte de sus trabajos fueron realizados en colaboración con André Lwoff,
Elie Wollman y Jacques Monod sucesivamente. Sin embargo, el estudio del conjunto de las publicaciones de François Jacob presenta un interés excepcional : ante todo por el papel mayor que le cupo en el desarrollo de la biología molecular ; luego, porque la elaboración del modelo fue esencialmente un trabajo de recolección y síntesis, cuyas etapas se ponen de manifiesto en las publicaciones escalonadas a lo largo de varios años ; finalmente, por la personalidad misma de François Jacob, quien desarrollo al mismo tiempo su trabajo cientítifico y su obra de filosofía de las ciencias. Es posible seguir la migración de conceptos de un campo disciplinario al otro : es raro encontrar una obra científica y una obra filosófica tan estrechamente mezcladas.
Nommer la forme et l'informe. La titraison comme genèse dans l'œuvre de Jean Dubuffet
Authors: Jakobi Marianne 
Published: April 2018

Os titulos de obras de arte constituem um corpus escrito pouco estudado, mas que ilumina os processos da criaçâo artfstica. Os titulos servem de go-between entre o pensamento e a obra de arte. Este artigo propôe uma leitura das etapas de elaboração dos tftulos encontrados nos arquivos das criaçôes de Jean Dubuffet. No centro de uma triangulação entre imagem mental (no sentido de representaçâo imaginãria suscitada pelo tftulo, em articulaçâo com a visão interior do artista), imagem icônica (correspondendo ao referente) e imagem plãstica (caracterizada por forma, cor, efeitos de sombra, de luz e de textura), os tftulos permitem à
imagem ganhar forma por um processo de transposição entre linguagem, pensamento e matéria. E esse processo de intitulação como génese que extrafmos dos bastidores criativos do artista-escritor. A dinâmica da génese das formas, a partir de dois tipos de transformação, o esboço e o recuo, trava um conflito entre a atracçâo pelos fenômenos opticos e a contrario pelo mundo abstracto das ideias e a sua passagem à escrita. Os titulos revelam um processo criativo que confessa segredos de atelier e que deixa entrever a fabricação das obras.
The ordo scribarum : a study in the loss of memory
Authors: Purcell Nicholas 
Published: April 2018

The article attempts a re-evaluation of the history of the Roman public scribae.
It emphasizes the ambiguous power offered to these experts by their control of information and their proximity to the magistrates, in the age when both imperium
and the fiscal system were developing rapidly. This power was naturally expressed in the domain of social promotion and upward mobility. Anxieties arising from the opportunities open to scribae can be discerned in the anecdotal record, and in the public legislation of the late Republic. The epigraphic evidence for the scribal statussystem is examined afresh, and new proposals are offered for the working of the complex structure of grades within it : it is argued that there is an important distinction between scribae tout court and scribae librarii. The Sullan lex de XX quaestoribus is also re-examined, and new suggestions offered on the meaning of
decuria in the apparitorial context. It is argued that the Empire largely brought an end to the tensions connected with public scribae, and saw a fossilization of the system of the end of the Republic.
Les rapports institutionnels et politiques d’Ostie et de Rome de la République au IIIe siècle ap. J.-C.
Authors: Cébeillac-Gervasoni Mireille 
Published: April 2018

Au cours d’une minutieuse enquête qui a pris en compte tous les témoignages littéraires et surtout épigraphiques, on constate que malgré un fonctionnement en apparence normal des institutions autonomes de la colonie romaine d’Ostie, Rome, sous la République comme sous l’Empire, a étroitement contrôlé Ostie. Sous la République, les autorités urbaines par le biais de certains magistrats (préteur urbain et
quaestor ostiensis qui avait son siège dans la colonie) limitaient fortement la marge d’autonomie locale ; cette recherche a été l’occasion de repréciser les fonctions exactes que devait assurer le titulaire de cette magistrature très peu appréciée par les jeunes élus en début de cursus sénatorial, lors du tirage au sort. Par ailleurs, grâce à une relecture de certaines lettres de Cicéron du printemps 45, on a pu démontrer que les grandes familles aristocratiques romaines possédaient sur le territoire d’Ostie des propriétés de rapport destinées à produire des denrées vendues fraîches sur le marché de Rome. Sous l’Empire la disparition du poste de questeur d’Ostie sous Claude ne fait qu’entériner une situation de fait : désormais, c’est l’administration de l’annone qui, sous l’autorité du préfet de l’annone au Ier siècle, puis du procureur de l’annone à partir de Trajan, va avoir la haute-main sur le transit du blé à Ostie, rôle de plus en plus essentiel pour l’Urbs, confrontée désormais de manière cruciale au problème de son approvisionnement qui lui parvient par mer depuis le dispositif portuaire de Ostie et Portus.