bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship Between the U.S. State Alcohol Policy Environment and Individuals’ Experience of Secondhand Effects: Alcohol Harms Due to Others’ Drinking
Authors: Greenfield Thomas K. , Cook Won K. , Karriker‐Jaffe Katherine J. , Patterson Deidre , Kerr William C. , Xuan Ziming , Naimi Timothy S. 
Published: June 2019

BackgroundAlthough restrictive state alcohol policy environments are protective for individuals’ binge drinking, research is sparse on the effect of alcohol policies on alcohol's harms to others (AHTO). We examined the lagged associations between efficacy of U.S. state alcohol policies and number of harms from others’ drinking 1 year later.MethodsIndividuals with AHTO data in a nationally representative sample of U.S. adults (analytic sample n = 26,744) that pooled the 2000, 2005, 2010, and 2015 National Alcohol Surveys and a 2015 National Alcohol's Harm to Others Survey were linked with prior‐year state policy measures. We used 2 measures from the Alcohol Policy Scale (APS)—effectiveness in reducing (i) binge drinking and (ii) impaired driving, based on experts’ efficacy judgments regarding 29 state alcohol policies. Three 12‐month AHTO measures (due to another drinker) were experiencing: (i) either family/marriage difficulties or financial troubles; (ii) being assaulted or vandalized; and (iii) passenger with drunk driver or traffic accident. Multilevel models accounting for clustering within states and stratified by age‐groups (<40 vs. ≥40) examined associations between the APS and AHTO measures, controlling for individual covariates (gender, race, education, employment and marital status, family problem‐drinking history) of the victim.ResultsOnly for those aged <40, the lagged APS‐Binge drinking and APS‐Impaired driving scores were each inversely associated with aggression‐related harms and, separately, with drunk driving‐related harm from someone else's drinking (ps < 0.05 to < 0.01). Family/financial harms were not associated with APS scores for either age‐group. Composite AHTO measures (any of 3 harm‐types) also were inversely associated with stronger state alcohol policy environments (ps < 0.05 to <0.01).ConclusionsState alcohol policies may be effective in reducing, to a meaningful degree, aggression‐related harms and vehicular hazards due to other drinkers, but mainly in those under 40.
The plant product quinic acid activates Ca2+‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells
Authors: Heikkilä Eija , Hermant Aurelie , Thevenet Jonathan , Bermont Flavien , Kulkarni Sameer S. , Ratajczak Joanna , Santo‐Domingo Jaime , Dioum El Hadji , Canto Carles , Barron Denis , Wiederkehr Andreas , De Marchi Umberto 
Published: June 2019

Background and PurposeQuinic acid (QA) is an abundant natural compound from plant sources which may improve metabolic health. However, little attention has been paid to its effects on pancreatic beta‐cell functions, which contribute to the control of metabolic health by lowering blood glucose. Strategies targeting beta‐cell signal transduction are a new approach for diabetes treatment. This study investigated the efficacy of QA to stimulate beta‐cell function by targeting the basic molecular machinery of metabolism–secretion coupling.Experimental ApproachWe measured bioenergetic parameters and insulin exocytosis in a model of insulin‐secreting beta‐cells (INS‐1E), together with Ca2+ homeostasis, using genetically encoded sensors, targeted to different subcellular compartments. Islets from mice chronically infused with QA were also assessed.Key ResultsQA triggered transient cytosolic Ca2+ increases in insulin‐secreting cells by mobilizing Ca2+ from intracellular stores, such as endoplasmic reticulum. Following glucose stimulation, QA increased glucose‐induced mitochondrial Ca2+ transients. We also observed a QA‐induced rise of the NAD(P)H/NAD(P)+ ratio, augmented ATP synthase‐dependent respiration, and enhanced glucose‐stimulated insulin secretion. QA promoted beta‐cell function in vivo as islets from mice infused with QA displayed improved glucose‐induced insulin secretion. A diet containing QA improved glucose tolerance in mice.Conclusions and ImplicationsQA modulated intracellular Ca2+ homeostasis, enhancing glucose‐stimulated insulin secretion in both INS‐1E cells and mouse islets. By increasing mitochondrial Ca2+, QA activated the coordinated stimulation of oxidative metabolism, mitochondrial ATP synthase‐dependent respiration, and therefore insulin secretion. Bioactive agents raising mitochondrial Ca2+ in pancreatic beta‐cells could be used to treat diabetes.
Interleukin-17 and -22 synergy linking inflammation and EMT-dependent fibrosis in Sjögren’s syndrome
Authors: Sisto M , Lorusso L , Tamma R , Ingravallo G , Ribatti D , Lisi S 
Published: June 2019

Summary
Primary Sjögren’s syndrome (pSS) is a chronic inflammatory, autoimmune and systemic disorder commonly associated with dry eyes and a dry mouth. Recently, the hypothetical link between epithelial–mesenchymal transition (EMT)-dependent salivary gland (SG) fibrosis and chronic inflammatory conditions has been suggested. In this study, we present data demonstrating a negative correlation of the epithelial marker E-cadherin expression and a positive correlation of mesenchymal vimentin and collagen type I expression with increasing degrees of tissue inflammation in pSS SG specimens. In addition, as it is not clear whether dysregulated cytokines in pSS, interleukin (IL)-17 and IL-22 may also contribute to the EMT-dependent fibrosis process, the effect of IL-17 and IL-22 treatment on EMT-dependent SG fibrosis was evaluated in primary human salivary gland epithelial cells (SGEC) isolated from healthy subjects. Here we present data demonstrating that IL-17 and IL-22 can induce SGEC to undergo a morphological and phenotypical transition to a mesenchymal phenotype. In support of this, vimentin and collagen type I were up-regulated while a decreased expression of E-cadherin occurs after interleukin treatment, and co-operation between IL-17 and Il-22 was required to induce the EMT.
School Meals and Food Poverty: Children’s Views, Parents’ Perspectives and the Role of School
Authors: Cardoso Sónia Goulart , Truninger Mónica , Ramos Vasco , Augusto Fábio Rafael 
Published: June 2019

This paper addresses the importance of school meals in balancing food budgets and diets among 45 low‐income families in Portugal. Drawing on interviews with both parents and children (aged 11–15 years) we found that children’s views on the quality of school meals affect their willingness to eat at school and heighten parental concerns with health, food and resources. For parents, school meals are crucial to ensure children’s dietary variety and balancing tight food budgets. Schools’ role in food poverty alleviation is also critically addressed, contributing to current and future sociological studies of children, school meals and food poverty.
Do social ties matter for corporate bond yield spreads? Evidence from China
Authors: Qiu Xuemei , Su Zhong‐qin , Xiao Zuoping 
Published: June 2019

AbstractResearch Question/IssueThis paper studies the effect of top management team (TMT) network centrality on corporate bond yield spreads. In additional analyses, we examine the hierarchical structures of TMT and study which parts contribute to the decrease in bond yield spreads. We also examine the mediating roles (including informed trading probability, media coverage, political ties, financial ties, and bond ratings) and the moderating roles (including marketization and analysts following) in the correlation between TMT network centrality and corporate bond yield spreads.Research Findings/InsightsThis paper finds that firms with high TMT network centrality are significantly negatively correlated with lower bond yield spreads. The findings are robust after controlling for a series of sensitivity checks and endogenous concerns. The results of the hierarchical structures show that the decrease of bond spreads is accounted for CFOs' networks and board members' networks, whereas the role of CEOs' networks is not apparent. More importantly, after controlling CEOs' networks, CFOs' networks, and board members' networks, the centrality of all TMT members' networks remains statistically significant, indicating that firms can benefit from the interlocking of all TMT members (not just the senior members). From the mediating effect results, we find that high TMT network centrality increases the value of a firm's probability of informed trading and its bond ratings while also increasing a firm's access to media coverage, political ties, and financial ties, which in turn can help lower bondholder' risk premiums. The moderating effect results show that the higher the marketization index and the more analysts following a firm, the higher the benefit of TMT network centrality to bond spreads.Theoretical/Academic ImplicationsThe results provide strong evidence that bondholders require lower bond yield spreads for firms with higher TMT network centrality, which suggests that TMT network centrality is critically essential for firms to obtain resources and to build a good corporate image and reputation; TMT network centrality can also lead to better information flow.Practitioner/Policy ImplicationsThis paper can inform various stakeholders about the impact of high TMT network centrality on bond yield spreads. It would be helpful to ensure the reasonable pricing of corporate bonds and to promote healthy and sound development of the bond market.
Endoscopic ultrasound‐guided versus endoscopic retrograde cholangiopancreatography‐guided biliary drainage for primary treatment of distal malignant biliary obstruction: A systematic review and meta‐analysis
Authors: Jin Zheng , Wei Yaping , Lin Huapeng , Yang Jing , Jin Hangbin , Shen Sisi , Zhang Xiaofeng 
Published: June 2019

ObjectivesCurrent evidence supporting the utility of endoscopic ultrasound‐guided biliary drainage (EUS‐BD) as primary treatment for distal malignant biliary obstruction (MBO) is limited. We conducted a meta‐analysis to compare the performance of EUS‐BD and endoscopic retrograde cholangiopancreatography‐guided biliary drainage (ERCP‐BD) as primary palliation of distal MBO.MethodsWe searched several databases for comparative studies evaluating EUS‐BD vs. ERCP‐BD in primary drainage of distal MBO up to 28 February 2019. Primary outcomes were technical success and clinical success. Secondary outcomes included adverse events, stent patency, stent dysfunction, tumor in/overgrowth, reinterventions, procedure duration, and overall survival.ResultsFour studies involving 302 patients were qualified for the final analysis. There was no difference in technical success (risk ratio [RR] 1.00; 95% confidence interval [95% CI] 0.93–1.08), clinical success (RR 1.00; 95% CI 0.94–1.06) and total adverse events (RR 0.68; 95% CI: 0.31–1.48) between the two procedures. EUS‐BD was associated with lower rates of post‐procedure pancreatitis (RR 0.12; 95% CI 0.02–0.62), stent dysfunction (RR 0.54; 95% CI 0.32–0.91), and tumor in/overgrowth (RR 0.22; 95% CI 0.07–0.76). No differences were noted in reinterventions (RR 0.59; 95% CI 0.21–1.69), procedure duration (weighted mean difference −2.11; 95% CI −9.51 to 5.29), stent patency (hazard ratio [HR] 0.61; 95% CI 0.34–1.11), and overall survival (HR 1.00; 95% CI 0.66–1.51).ConclusionsWith adequate endoscopy expertise, EUS‐BD could show similar efficacy and safety when compared with ERCP‐BD for primary palliation of distal MBO and exhibits several clinical advantages.
Structural abnormalities in hypertrophic cardiomyopathy beyond left ventricular hypertrophy by multimodality imaging evaluation
Authors: Urbano‐Moral Jose Angel , Gutierrez‐Garcia‐Moreno Laura , Rodriguez‐Palomares Jose Fernando , Matabuena‐Gomez‐Limon Javier , Niella Natalia , Maldonado Giuliana , Valle‐Racero Juan Ignacio , Niella Marcela , Teixido‐Tura Gisela , Garcia‐Dorado David , Ferrazzi Paolo , Pandian Natesa G. , Evangelista‐Masip Arturo 
Published: June 2019

AbstractBackgroundEchocardiography‐ and cardiovascular magnetic resonance (CMR)‐based studies have revealed a wide range of phenotypic manifestations in hypertrophic cardiomyopathy (HCM) apart from hypertrophy. This study sought to comprehensively describe a number of structural abnormalities in HCM beyond hypertrophy, by multimodality imaging.MethodsA total of 100 HCM patients were prospectively enrolled, undergoing standard and contrast echocardiography, and CMR. Morphological characteristics involving mitral valve leaflets (MVL), subvalvular apparatus, and left ventricular cavity and wall were investigated. Seventy healthy volunteers served as control population.ResultsAs assessed by echo, MVLs were longer in HCM patients than in controls (anterior method 1: 24[22,28] vs 19[18,20] mm, P < 0.01; anterior method 2: 27[24, 29] vs 21[19, 23] mm, P < 0.01; posterior: 15[12,19] vs 14[13,15] mm, P < 0.01). Abnormal chordal attachment to anterior MVL, anterior papillary muscle displacement, and accessory apical‐basal muscle bundle were present in 42 (42%), 61 (61%), and 35 (35%) patients, respectively (P values vs controls <0.01); direct papillary muscle insertion into MVL and hypertrabeculation were found in two and five patients, respectively. Contrast echocardiography (n = 94) detected myocardial crypts in 15 patients (16%). Overall, 83% of HCM subjects had at least one of these phenotypic manifestations. Echocardiography and CMR agreement for MVL length was poor, while for structural characteristics was moderate to substantial (Cohen's Kappa: 0.53‐1.00). Except for posterior MVL length and hypertrabeculation, the phenotypic characteristics studied had acceptable reproducibility by echocardiography and CMR.ConclusionsStructural abnormalities in HCM beyond hypertrophy are significantly common. Multimodality imaging approach to these HCM facets by echocardiography and CMR is feasible and desirable.
Hippocampal diffusion abnormality after febrile status epilepticus is related to subsequent epilepsy
Authors: Yokoi Setsuri , Kidokoro Hiroyuki , Yamamoto Hiroyuki , Ohno Atsuko , Nakata Tomohiko , Kubota Tetsuo , Tsuji Takeshi , Morishita Masashi , Kawabe Takashi , Naiki Misako , Maruyama Koichi , Itomi Kazuya , Kato Toru , Ito Komei , Natsume Jun 
Published: June 2019

AbstractObjectiveTo assess hippocampal signal changes on diffusion‐weighted imaging (DWI) during the acute period after febrile status epilepticus (FSE) and to examine the relationship between DWI and subsequent epilepsy.MethodsA prospective, multicenter study of children with a first episode of FSE was performed. The patients underwent magnetic resonance imaging (MRI) within 3 days of FSE, and signal intensity was evaluated on DWI. Electroencephalography studies within 3 days of FSE were also assessed. Nine to 13 years after FSE, information on subsequent epilepsy was obtained.ResultsTwenty‐two children with FSE were evaluated. DWI showed unilateral hippocampal hyperintensity in six patients (27%). Three of six patients with hippocampal hyperintensity had ipsilateral thalamic hyperintensity. On EEG within 3 days of FSE, five of six patients with hippocampal hyperintensity had ipsilateral focal slowing, spikes, or attenuation. Nine to 13 years later, the outcomes could be determined in five patients with hippocampal hyperintensity and in 10 without. All 5 patients with hippocampal hyperintensity had hippocampal atrophy and developed focal epilepsy, whereas only 1 of 10 patients without hippocampal hyperintensity developed epilepsy (P = 0.002). Ictal semiology was concordant with temporal lobe seizures in all patients. Ipsilateral temporal epileptiform abnormalities were seen on EEG in four of five at last follow‐up.SignificanceAcute DWI hippocampal hyperintensity was seen in 27% of patients with FSE. Acute DWI hyperintensity suggests cytotoxic edema caused by prolonged seizure activity. Hippocampal DWI hyperintensity is related to mesial temporal lobe epilepsy and can be a target of neuroprotective treatments to prevent the onset of epilepsy.
Diagnosis, management and prognosis of large colon impactions
Authors: Hanson R. Reid , Schumacher J. 
Published: June 2019

SummaryThe majority of large colon feed impactions occur in the left ventral colon at the pelvic flexure. Sand and enterolith impactions most commonly occur in the left ventral colon at the pelvic flexure or in the right dorsal colon; however, sand can accumulate anywhere along the gastrointestinal tract. Enteral fluid therapy can, in most cases, supplement or even replace i.v. administration of fluids and it appears effective and safe to soften large colon contents and resolve simple large colon impactions. Surgical intervention is indicated when a concurrent displacement is suspected, as lengthy medical treatment of large colon impaction secondary to large colon displacements would not be indicated and may increase the risk of colonic rupture. Other indications for surgical intervention include uncontrollable pain, when cardiovascular parameters deteriorate, or when there is evidence of intestinal devitalisation. The prognosis for horses undergoing large colon enterotomy is dependent on the extent and type of impaction, but is generally excellent.
The climatic drivers of primary Picea forest growth along the Carpathian arc are changing under rising temperatures
Authors: Schurman Jonathan S. , Babst Flurin , Björklund Jesper , Rydval Miloš , Bače Radek , Čada Vojtěch , Janda Pavel , Mikolas Martin , Saulnier Mélanie , Trotsiuk Volodymyr , Svoboda Miroslav 
Published: June 2019

AbstractClimatic constraints on tree growth mediate an important link between terrestrial and atmospheric carbon pools. Tree rings provide valuable information on climate‐driven growth patterns, but existing data tend to be biased toward older trees on climatically extreme sites. Understanding climate change responses of biogeographic regions requires data that integrate spatial variability in growing conditions and forest structure. We analyzed both temporal (c. 1901–2010) and spatial variation in radial growth patterns in 9,876 trees from fragments of primary Picea abies forests spanning the latitudinal and altitudinal extent of the Carpathian arc. Growth was positively correlated with summer temperatures and spring moisture availability throughout the entire region. However, important seasonal variation in climate responses occurred along geospatial gradients. At northern sites, winter precipitation and October temperatures of the year preceding ring formation were positively correlated with ring width. In contrast, trees at the southern extent of the Carpathians responded negatively to warm and dry conditions in autumn of the year preceding ring formation. An assessment of regional synchronization in radial growth variability showed temporal fluctuations throughout the 20th century linked to the onset of moisture limitation in southern landscapes. Since the beginning of the study period, differences between high and low elevations in the temperature sensitivity of tree growth generally declined, while moisture sensitivity increased at lower elevations. Growth trend analyses demonstrated changes in absolute tree growth rates linked to climatic change, with basal area increments in northern landscapes and lower altitudes responding positively to recent warming. Tree growth has predominantly increased with rising temperatures in the Carpathians, accompanied by early indicators that portions of the mountain range are transitioning from temperature to moisture limitation. Continued warming will alleviate large‐scale temperature constraints on tree growth, giving increasing weight to local drivers that are more challenging to predict.
Response of maize biomass and soil water fluxes on elevated CO2 and drought—From field experiments to process‐based simulations
Authors: Kellner Juliane , Houska Tobias , Manderscheid Remy , Weigel Hans‐Joachim , Breuer Lutz , Kraft Philipp 
Published: June 2019

AbstractThe rising concentration of atmospheric carbon dioxide (CO2) is known to increase the total aboveground biomass of several C3 crops, whereas C4 crops are reported to be hardly affected when water supply is sufficient. However, a free‐air carbon enrichment (FACE) experiment in Braunschweig, Germany, in 2007 and 2008 resulted in a 25% increased biomass of the C4 crop maize under restricted water conditions and elevated CO2 (550 ppm). To project future yields of maize under climate change, an accurate representation of the effects of eCO2 and drought on biomass and soil water conditions is essential. Current crop growth models reveal limitations in simulations of maize biomass under eCO2 and limited water supply. We use the coupled process‐based hydrological‐plant growth model Catchment Modeling Framework‐Plant growth Modeling Framework to overcome this limitation. We apply the coupled model to the maize‐based FACE experiment in Braunschweig that provides robust data for the investigation of combined CO2 and drought effects. We approve hypothesis I that CO2 enrichment has a small direct‐fertilizing effect with regard to the total aboveground biomass of maize and hypothesis II that CO2 enrichment decreases water stress and leads to higher yields of maize under restricted water conditions. Hypothesis III could partly be approved showing that CO2 enrichment decreases the transpiration of maize, but does not raise soil moisture, while increasing evaporation. We emphasize the importance of plant‐specific CO2 response factors derived by use of comprehensive FACE data. By now, only one FACE experiment on maize is accomplished applying different water levels. For the rigorous testing of plant growth models and their applicability in climate change studies, we call for datasets that go beyond single criteria (only yield response) and single effects (only elevated CO2).