bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Destiny and Divine Providence in Two Byzantine Authors of the Early Eighth Century
Authors: Baranov Vladimir 
Published: July 2019

Abstract
The well-being of a person was viewed by the Byzantines as a complex interplay of divine providence, guiding a person throughout his life to salvation, and his will, freely choosing between virtue and sin. Several solutions were given to the problem of misfortunes which might befall a person, since they could not result from the actions of a good God: from ultimate non-involvement of God into the voluntary actions of humans, to pedagogical temporary “stepping aside” by God to demonstrate the futility of human actions which go against the best predestined course of life, to active divine intervention as “bitter medicine” for the correction of human wrongdoings and putting an end to uncorrected sin. These problems are discussed in the treatise On the Predestined Terms of Life by Patriarch Germanus I of Constantinople and in the Dialogue against the Manichees by John of Damascus, who thoroughly adapted and reworked the Homily That God Is Not the Author of Evil by Basil of Caesarea for the discussion of theodicy.
The Conversion of Pachomius Revisited
Authors: Barthel Christian 
Published: July 2019

Abstract
The article seeks to reassess and contextualise the conversion narrative of the Egyptian monk Pachomius, the founder of coenobitic monasticism. It thereby offers a case study into how and why the Pachomian literary tradition was shaped, altered and abridged, while also challenging the traditional views associated with Pachomius’ military career.
A Byzantine Logician’s “Image” within the Second Iconoclastic Controversy. Theodore the Studite
Authors: Goncharko Oksana Yu. , Goncharko Dmitry N. 
Published: July 2019

Abstract
The paper is devoted to the reconstruction of the “iconophilistic” logic theory built by Theodore the Studite in his pro-icon writings during the “scholastic” period of the Second Iconoclasm Christological controversy. We argue that Theodore the Studite invented the non-Aristotelian identity distinction and implemented the two types of identity (the identity of nature and the identity of hypostasis) within his Christological argumentation, demonstrating how the contradictory properties of the two natures of Christ should be accepted consistently. The main issue of the present paper is to discuss the examples of non-classical logical thinking undertaken by Theodore the Studite, which are devoted to the description of how the identity principle should work, why the icon principle is self-referential, and why the duality of the properties of Christ should be accepted by all Christians in order to be iconophiles and logically correct at the same time.
Al-Makīn ibn al-ʿAmīd on Moses of Crete
Authors: Seleznyov Nikolai N. 
Published: July 2019

Abstract
In the first, still unpublished, volume of The Blessed Compendium (al-Majmūʿ al-mu­bārak) – the historical work of the 13th-century Arabic-speaking Christian writer al-Makīn ibn al-ʿAmīd, there is a chapter on the Byzantine Emperor Theodosius II the Younger (r. 402-450). In this chapter, Ibn al-ʿAmīd retells the famous story of Moses of Crete, “who appeared among the Jews” and declared himself to be the Messiah to subsequent tragic disappointment of those who believed in him. The present article discusses this story and suggests an explanation for the discrepancies between Ibn al-ʿAmīd’s text and its Arabic source – the Book of the Heading (Kitāb al-ʿUnwān) of Agapius of Manbij (Hierapolis).
A new myrmecophilous mite species of the genus Cosmolaelaps Berlese, 1903 (Acari, Mesostigmata, Laelapidae) from Central Europe (Slovakia)
Authors: MAŠÁN PETER , BABAEIAN ESMAEIL 
Published: July 2019

A new laelapid mite of the genus Cosmolaelaps Berlese, 1903, C. ekaterinae sp. n., is described based on female and male adults found in a mixed ant colony of Lasius umbratus (Nylander, 1846) infiltrated by another congeneric species, Lasius fuliginosus (Latreille, 1798). The new species is unusual for Cosmolaelaps in having dorsal setae that are particularly elongate and tapered. In addition to the new species description, we comment on the classification of some species that were recently included in Cosmolaelaps.
The Origin of Soil Moisture Evaporation “Regimes”
Authors: Vargas Zeppetello Lucas R. , Battisti David S. , Baker Marcia B. 
Published: July 2019

Abstract
Evaporation plays an extremely important role in determining summertime surface temperature variability over land. Observations show the relationship between evaporation and soil moisture generally conforms to the Budyko “two regime” framework; namely, that evaporation is limited by available soil moisture in dry climates and by radiation in wet climates. This framework has led climate models to different parameterizations of the relationship between evaporation and soil moisture in wet and dry regions. We have developed the Simple Land–Atmosphere Model (SLAM) as a tool for studying land–atmosphere interaction in general, and summertime temperature variability in particular. We use the SLAM to show that a negative feedback between evaporation and surface temperature gives rise to the two apparent evaporation “regimes” and provide analytic solutions for evaporative cooling anomalies that demonstrate the nonlinear impact of soil moisture perturbations. Stemming from the temperature dependence of vapor pressure deficit, the feedback we identify has important implications for how transitions between wet and dry land surfaces may impact temperature variability as the climate warms. We also elucidate the impacts of surface moisture and insolation perturbations on latent and sensible heat fluxes and on surface temperature variability.
Multivariate Ensemble Sensitivity Analysis for Super Typhoon Haiyan (2013)
Authors: Ren Sijing , Lei Lili , Tan Zhe-Min , Zhang Yi 
Published: July 2019

Abstract
Ensemble sensitivity is often a diagonal approximation to the multivariate regression, leading to a simple univariate regression. Comparatively, the multivariate ensemble sensitivity retains the full covariance matrix when computing the multivariate regression. The performances of both univariate and multivariate ensemble sensitivities in multiscale flows have not been thoroughly examined, and the demonstration of the latter in realistic applications has been sparse. A high-resolution ensemble forecast of Typhoon Haiyan (2013) is used to examine the performances of the two ensemble sensitivities. Compared to the multivariate sensitivity, the univariate sensitivity overestimates the forecast metric, especially at higher levels. To increase the predicted Haiyan’s intensity, multivariate ensemble sensitivity gives initial perturbations characterized by a warming area around the center of the storm, an increased moisture area around the eyewall, a stronger primary circulation around the radius of maximum wind, and stronger inflow at low levels and stronger outflow at high levels. Perturbed initial condition experiments verify that the predicted response from the multivariate sensitivity is more accurate than that from the univariate sensitivity. Therefore, the ability of multivariate sensitivity to provide more accurate predicted responses than the univariate sensitivity has been demonstrated in a realistic multiscale flow application.
Clozapine and tardive dyskinesia in patients with schizophrenia: A systematic review
Authors: Pardis Parnian , Remington Gary , Panda Roshni , Lemez Milan , Agid Ofer 
Published: July 2019

Background: It is commonly recommended that a switch to clozapine be implemented in the face of tardive dyskinesia, even if current treatment involves another “atypical” agent. However, reports do indicate clozapine carries a liability for tardive dyskinesia. Aims: This review sought to evaluate clozapine in relation to tardive dyskinesia in the context of available evidence. Methods: Medline, Embase, and PsycINFO databases were searched for studies published in English, using the keywords: clozapine AND tardive dyskinesia OR TD. References from major review articles were searched for additional relevant publications. Studies were included if they investigated: tardive dyskinesia in clozapine-treated patients diagnosed with schizophrenia spectrum disorders, and reported on two or more assessments of tardive dyskinesia severity measured by the Abnormal Involuntary Movement Scale; or clozapine’s tardive dyskinesia liability. Results: In total, 513 unique citations were identified and 29 reports met the inclusion criteria. Thirteen studies suggest clozapine reduces dyskinetic symptoms over time ( n=905 clozapine-treated participants); however, the minimum required dose and effect of withdrawal requires further investigation. The majority of reports which address clozapine’s liability for tardive dyskinesia are case studies (11 of 14 reports, 79%), and clozapine was only the first-line treatment in one of the remaining three studies reporting treatment-emergent dyskinetic symptoms with clozapine in 12% of patients. No significant between-drug differences were identified comparing clozapine’s risk to other atypical antipsychotics. Conclusions: Research to date supports switching to clozapine for the purpose of reducing tardive dyskinesia risk and/or treating existing tardive dyskinesia, but prospective randomized controlled trials are necessary if we are to substantiate existing recommendations.
Surface characterization of nanostructured commercially pure titanium modified by sandblasting and acid-etching for implant applications
Authors: Reshadi F , Khorasani S , Faraji G 
Published: July 2019

This study investigated the surface characteristics of ultrafine-grain commercially pure titanium (UFG CP-Ti) substrates produced by equal channel angular pressing (ECAP), compared with those of coarse-grain commercially pure titanium (CG CP-Ti) and Ti–6Al–4V (Ti-64) substrates. All Ti surfaces were sandblasted and acid-etched (SLA-treated) to produce micro-rough surfaces. Tensile and microhardness tests were carried out to measure the mechanical properties of fabricated samples. Then the surface characteristics of samples including contact angle measurements, surface morphology and in vitro cell response were evaluated after polishing, sandblasting and acid etching procedures. The results showed that after applying four passes of ECAP, the average grain size of microstructure decreased from 25 µm to 170 nm, while the ultimate tensile strength increased from 545 ± 24 MPa to 971 ± 38 MPa. Investigation of surface morphologies carried out by scanning electron microscopy indicated that ECAP-processed substrate exhibits nano-topography compared with CG CP-Ti and Ti-64 substrates after applying SLA process. In addition, the contact angle of SLA-treated CG CP-Ti and UFG CP-Ti substrates decreased from 68.3° to 9.5° and 51.9° to 7.4°, respectively, indicating a significant improvement of surface wettability. The morphologies of MG63 cells cultured on the developed surfaces proved the potential superior osteoblast cell compatibility of the micro-roughened surface made of UFG CP-Ti substrates over CG CP-Ti and Ti-64 substrates.
Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remission
Authors: Haifer Craig , Lawrance Ian C. , Center Jacqueline R. , Clarke Michael W. , Hart Prue H. , Eisman John A. , Lucas Robyn , Ghaly Simon 
Published: July 2019

Background: Vitamin D deficiency is associated with active Crohn’s disease (CD). However, it remains unclear if lower 25-hydroxyvitamin D [25(OH)D] concentration is the cause, or consequence, of intestinal inflammation. Existing literature has focused on circulating 25(OH)D rather than the active metabolite 1,25(OH)2D, or its breakdown product, 24,25(OH)2D. We aimed to characterise vitamin D metabolism in a cohort of patients with active and inactive CD. Methods: Fifty-four patients with CD and not on corticosteroids or vitamin D supplements, were enrolled in a 6-month prospective cohort study. Sera were collected on enrolment and at 6 months and tested for 25(OH)D, 1,25(OH)2D, 24,25(OH)2D using liquid chromatography tandem mass spectroscopy as well as vitamin-D-binding protein. Results: There were no differences in 25(OH)D or 1,25(OH)2D levels between participants with active versus inactive disease. Levels of 24,25(OH)2D were significantly lower in those with active compared with inactive disease (mean 3.9 versus 6.0 µmol/l; p = 0.007) and therefore the ratio of 25(OH)D:24,25(OH)2D was higher (mean 17.3 versus 11.1; p = 0.001). In those patients with active disease who achieved remission, there was a mean increase in 25(OH)D of 32.3 nmol/l (i.e. to a level in the sufficient range) and 24,25(OH)2D of 2.1 µmol/l. These increases were not seen in patients with persistently active or inactive disease. Conclusion: Levels of 24,25(OH)2D, but not 25(OH)D, were lower in patients with active CD, and spontaneously increased with resolution of underlying inflammation. The utility of 24,25(OH)2D as a biomarker of disease activity and vitamin D status in CD warrants further exploration.
Exercise chronotropic incompetence phenotypes the level of cardiovascular risk and exercise gas exchange impairment in the general population. An analysis of the Euro-EX prevention trial
Authors: Laforgia Pietro , Bandera Francesco , Alfonzetti Eleonora , Guazzi Marco 
Published: July 2019

Background Chronotropic insufficiency (CI) is defined as the inability of the heart to increase its rate commensurate with increased demand. Exercise CI is an established predictor of major adverse cardiovascular events in patients with cardiovascular diseases. Aim The aim of this study was to evaluate how exercise CI phenotypes different levels of cardiovascular risk and how it may better perform in defining cardiovascular risk when analysed in the context of cardiopulmonary exercise test (CPET)-derived measures and standard echocardiography in a healthy population with variable cardiovascular risk profile. Methods Apparently healthy individuals ( N = 702, 53.8% females) with at least one major cardiovascular risk factor (MCVRF; hypertension, diabetes, tabagism, dyslipidaemia, body mass index > 25), enrolled in the Euro-EX prevention trial, underwent CPET. CI was defined as the inability to reach 80% of the chronotropic index, that is, the ratio of peak heart rate – rest heart rate/peak heart rate – age predicted maximal heart rate (AMPHR: 220 – age), they were divided into four groups according to the heart rate reserve (<80%>) and respiratory gas exchange ratio (RER; < 1.05>) as a marker of achieved maximal performance. Subjects with a RER < 1.05 ( n = 103) were excluded and the final population ( n = 599) was divided into CI group ( n = 472) and no-CI group ( n = 177). Results Compared with no-CI, CI subjects were more frequently females with a history of hypertension in a high rate. CI subjects also exhibited a significantly lower peak oxygen uptake (VO2) and circulatory power and an echocardiographic pattern indicative of higher left atrial volume index and left ventricular mass index. An inverse stepwise relationship between heart rate reserve and number of MCVRFs was observed (one MCVRF: 0.71 ± 0.23; two MCVRFs: 0.68 ± 0.24, three MCVRFs: 0.64 ± 0.20; four MCVRFs: 0.64 ± 0.23; five MCVRFs: 0.57 ± 18; p < 0.01). In multivariate analysis the only variable found predicting CI was peak VO2 ( p < 0.05; odds ratio 0.91; confidence interval 0.85–0.97). Conclusions In a population of apparently healthy subjects, exercise CI is common and phenotypes the progressive level of cardiovascular risk by a tight relationship with MCVRFs. CI patients exhibit some peculiar abnormal exercise gas exchange patterns (lower peak VO2 and exercise oscillatory ventilation) and echo-derived measures (higher left atrium size and left ventricle mass) that may well anticipate evolution toward heart failure.
Epidemiology of Clavicle Fractures Among US High School Athletes, 2008-2009 Through 2016-2017
Authors: McCarthy Meagan M. , Bihl Jonathan H. , Frank Rachel M. , Salem Hytham S. , McCarty Eric C. , Comstock R. Dawn 
Published: July 2019

Background: Little is known about the epidemiology of clavicle fractures in United States (US) high school athletes. Sports participation among high school students has increased steadily, placing increased numbers at risk of sports-related injury. Purpose: To describe the epidemiology of clavicle fractures among high school athletes, including injury rates by sex, sport, and type of play and trends in operative versus nonoperative treatment. Study Design: Descriptive epidemiology study. Methods: The study data set included all athlete-exposure (AE) and clavicle fracture data collected from 2008-2009 through 2016-2017 from a large sample of US high schools as part of the National High School Sports-Related Injury Surveillance Study for students participating in boys’ football, boys’/girls’ soccer, boys’/girls’ basketball, boys’/girls’ volleyball, boys’ wrestling, boys’ baseball, girls’ softball, girls’ field hockey, boys’ ice hockey, boys’/girls’ lacrosse, boys’/girls’ swimming and diving, boys’/girls’ track and field, girls’ gymnastics, girls’ cheerleading, boys’/girls’ tennis, and boys’/girls’ cross-country. Results: Overall, 567 clavicle fractures were reported during 31,520,765 AEs, an injury rate of 1.80 per 100,000 AEs. Injury rates varied by sport, with the highest rates in the boys’ full-contact sports of ice hockey (5.27), lacrosse (5.26), football (4.98), and wrestling (2.21). Among girls’ sports, the highest rates were in soccer (0.92), lacrosse (0.26), and basketball (0.25). In sex-comparable sports, injury rates were still significantly higher among boys (1.03) than girls (0.35) (rate ratio, 2.91; 95% CI, 1.97-4.30). Injury rates were significantly higher in competition (4.58) as compared with practice (0.87) (rate ratio, 5.27; 95% CI, 4.44-6.26). Most injuries were treated conservatively (82.7%) rather than operatively (17.3%). Time to return to sports varied, with a greater proportion of medical disqualifications among those treated operatively (40.0%) as compared with those treated conservatively (22.6%) (injury proportion ratio, 1.77; 95% CI, 1.31-2.39). Conclusion: Although clavicle fracture rates are relatively low, they vary by sport, sex, and activity. Understanding such differences should drive more effective, targeted injury prevention efforts. Increased time loss from sports with surgical versus conservative treatment may have been influenced by factors including injury severity and its timing relative to the season’s progress.
Impact of concurrent indolent lymphoma on the clinical outcome of newly diagnosed diffuse large B-cell lymphoma
Authors: Wang Yucai , Link Brian K. , Witzig Thomas E. , Maurer Matthew J. , Allmer Cristine , King Rebecca L. , Feldman Andrew L. , Habermann Thomas M. , Ansell Stephen M. , Slager Susan L. , Cerhan James R. , Nowakowski Grzegorz S. 
Published: July 2019

Abstract
In this month's CME article, an analysis of over 1300 patients with diffuse large B-cell lymphoma (DLBCL), Wang et al demonstrate that the approximately 13% of patients with concurrent indolent lymphoma at diagnosis had the same prognosis as those patients with isolated DLBCL.
Effect of Sociodemographic Variables on Patient and Diagnostic Delay of Breast Cancer at the Foremost Health Care Institution in Nigeria
Authors: Olarewaju Sunday O. , Oyekunle Emmanuel O. , Bamiro Adebukola O. 
Published: July 2019

PURPOSEBreast cancer (BC) has the highest mortality rate among women with any form of cancer in developing countries. Unfortunately, patients with BC in Nigeria commonly present with late-stage disease. The current study examined the types and magnitude of delay in BC diagnosis at the foremost hospital in Nigeria and also identified the influencing factors.MATERIALS AND METHODSThis cross-sectional study involved questionnaires given to 275 patients with BC at University College Hospital, Ibadan, Nigeria, from August to October 2018. Sociodemographic characteristics and information relevant to management of their health problem were obtained after ethical committee approval. Data collected were analyzed by SPSS (version 23; SPSS, Chicago, IL) to assess the types and magnitude of delay experienced by patients, as well as identify related determinants using the appropriate statistical test with P = .05.RESULTSThe mean age of respondents was 49 (± 11.9) years with the majority being Yoruba (n = 154; 56%), Christians (n = 211; 76.7%), married (n = 193; 70.2%), employed (n = 151; 54.9%), having tertiary education (n = 142; 51.6%) and an average income of more than 18,000 naira (n = 176; 64%). Patient delay and diagnostic delay were observed among 97 respondents (35.3%) and 84 respondents (30.5%), respectively. Although patient delay was significantly associated with age, ethnicity, and marital status, the only variable significantly associated with diagnostic delay was marital status ( P < .05). Level of income, education, employment status, and religion did not significantly ( P > .05) contribute to either of these delays.CONCLUSIONBC management at the pioneer Nigerian teaching hospital is challenged by both delays in patient presentation at clinics and delays in the process of being diagnosed. Such delays need to be addressed to achieve favorable outcome of patients with BC in Nigeria.
Awake Volunteer Pain Scores During Neuromuscular Monitoring
Authors: Nemes Réka , Nagy György , Murphy Glenn S. , Logvinov Ilana I. , Fülesdi Béla , Renew J. Ross 
Published: July 2019

BACKGROUND:
There is a need for easy to use, reliable neuromuscular monitors (NMMs). This multicenter, prospective, unblinded study compared the discomfort associated with neurostimulation in unmedicated healthy volunteers when using the new electromyography (EMG)-based TetraGraph and acceleromyography (AMG)-based TOF-Watch NMMs. The secondary aim was to compare the repeatability of the train-of-four (TOF) ratios (TOFRs) obtained with the 2 devices.

METHODS:
The TOF measurements of 135 volunteers from 3 university hospitals were analyzed (age: 38.3 ± 12 years [mean ± standard deviation [SD]]; male/female ratio = 63:72). The left or right ulnar nerve was stimulated at the wrist in TOF mode with 20, 30, 40, and 50 mA stimulating current intensities with both devices in random order. The TOF-Watch used standard electrocardiography (ECG) electrodes (Red Dot; 3M Health Care) for nerve stimulation. The stimulating surface area of 1 ECG electrode is 113 mm2. The piezoelectric probe was attached to the thumb, and a hand adapter was used to ensure consistency of AMG measurements. The TetraGraph uses proprietary surface strip electrodes for nerve stimulation and muscle action potential recording, whose stimulating surface area is roughly twice as big as that of standard ECG electrodes (228.5 mm2). The volunteers were asked to rate the discomfort associated with neurostimulation on a 0–10 verbal numerical rating scale (VNRS) score anchored with 0 (no pain) and 10 (worst pain ever experienced). A linear mixed-effects model was used to evaluate the difference in VNRS scores between devices. P <.05 was accepted as the level of significance.

RESULTS:
In the linear mixed-effects model, there were no differences in VNRS scores between devices at any of the stimulating current intensities, P = .38. The median (range) VNRS scores obtained with TOF-Watch and TetraGraph devices were 2 (0–7) vs 2 (0–8) at 20 mA, 3 (1–9) vs 3 (1–9) at 30 mA, 5 (1–10) vs 5 (1–10) at 40 mA, and 5 (1–10) vs 6 (1–10) at 50 mA stimulating current intensities. The mean of the 1469 TOFRs obtained with TetraGraph was 100.43% ± 7.74% (standard error = 0.2%). Due to technical difficulties, the repeatability of the TOFRs could not be determined.

CONCLUSIONS:
Despite the different size and design of the stimulating electrodes, the 2 NMMs caused the same level of discomfort in unmedicated healthy volunteers.