bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEDICAMENTOS SUJEITOS A CONTROLE ESPECIAL MAIS UTILIZADOS EM CENTROS DE ATENÇÃO PSICOSSOCIAL EM UMA CIDADE DO PARANÁ
Authors: BOGER Beatriz , FEDERHEN Chayanne , BRAND Mayara , SZPAK Renata , PATRIOTA Beatriz , MORISHITA Linda , GOMES Eliane Carneiro 
Published: March 2018

O objetivo do trabalho foi identificar os medicamentos sujeitos a controle especial mais utilizados em Centros de Atenção Psicossocial (CAPS) no município de Curitiba, Paraná-BR. Estudo retrospectivo, por meio de pesquisa documental em Livros de Registro Específico de medicamentos controlados dos CAPS, referente aos anos de 2013 a 2016. Constatou-se a saída de 10.897 medicamentos, sendo as dispensações para uso emergencial. Foi considerada a denominação comum brasileira (DCB), a forma farmacêutica e as concentrações que eram dispensadas das seguintes classes terapêuticas: antidepressivos, ansiolíticos, antiepiléticos, antipsicóticos, anticolinérgicos e hipnóticos/sedativos. Os mais utilizados foram os antipsicóticos, em específico o Cloridrato de Clorpromazina em comprimido de 100mg (23,41%) e 25mg (18,54%), seguido do ansiolítico Diazepam em comprimido de 5mg (11,86%). O padrão de consumo de psicotrópicos aqui identificados não diferem muito dos estudos semelhantes em outras regiões do Brasil, além de evidenciar o consumo em caráter emergencial de algumas classes terapêuticas.
The Role of Hope and Self-efficacy on Nurses’ Subjective Well-being
Authors: Liu Ruiming , Zeng Pan , Quan Peng 
Published: March 2018

Although subjective well-being is considered important for nurses, the relationship between hope, self-efficacy, and subjective well-being among nurses has rarely been assessed. This study purposes to explore the relationships between hope, self-efficacy, and subjective well-being. The analysis relies on data from 1757 female nurses in 3 hospitals in China. Nurses completed a demographic form, General Self-efficacy Scale, Hope Scale, General Well-Being Schedule. A mediate model of the hypothesized relationships between the constructs was tested. Significant direct relationships of hope, self-efficacy, and subjective well-being were displayed. Mediation analyses reveal that the impact of self-efficacy on subjective well-being is partially mediated by two components of hope, agency and pathways. Hope was shown to be a key mediator for the relationships between self-efficacy and subjective well-being. These findings advance current understandings on the hopeful thinking in nurses.
Pasini ve Pierini'nin İdyopatik Atrofoderması ile Morfeanın Birlikteliği
Authors: KEMERİZ Funda , GÖNÜL Müzeyyen , GÖKÇE Aysun , ALPER Murat 
Published: March 2018

Pasini ve Pierini’nin İdiyopatik Atrofoderması (PPİA) nadir
görülen etyolojisi bilinmeyen bir dermal atrofi tipidir. Lezyonlar tek ya da
birden fazla oval ya da yuvarlak, simetrik , deriden hafif çökük, keskin
sınırlı plaklar şeklindedir. Çoğunlukla sırtta lokalize olan lezyonlar
sonrasında göğüs ve abdominal bölgede de ortaya çıkabilmektedir. Lezyonların
boyutu 1-20 cm arasında değişebilmektedir ve lezyonlar zaman içerisinde yavaşça
genişler. Hastaların çoğu kadın olup, genelde ikinci-üçüncü dekatlarda
görülmektedir. Nadiren PPİA ve morfea bir arada görülebilir.

Bu makalede sırtında asemptomatik çökük kahverengi leke ile
polikliniğimize başvuran, klinik ve histopatolojik bulgularla PPİA ve morfea
tanısı konulan 27 yaşında bayan hasta sunulmaktadır.
La désignation officielle de Vanier comme « le quartier francophone d’Ottawa » : sujet de discorde au sein de la minorité linguistique de la capitale canadienne
Authors: Benali Kenza 
Published: March 2018

La nomination des lieux ou les refontes toponymiques, de par leur dimension éminemment politique, sont souvent source de controverses. Les contextes multiculturels et multilingues, où les tensions identitaires sont souvent exacerbées, se présentent comme des terrains d’observation privilégiés. C’est le cas du Canada, où le champ toponymique est fortement marqué par la rivalité entre trois communautés linguistiques (anglaise, française, autochtone). Si ces conflits toponymiques intercommunautaires ont largement été investis par la recherche, on compte, en revanche, très peu d’études sur les tensions intracommunautaires. Cet article propose d’explorer ce type de conflit inhabituel à travers la controverse qu’a suscité le projet de désignation officielle d’un « quartier francophone » à Ottawa et qui a largement polarisé la minorité linguistique de la capitale.
Medición de la experiencia del turista en Quito
Authors: Matovelle Pablo Aníbal Torres , Baez Simone 
Published: March 2018

Aunque la experiencia del turista ha sido un tema profundamente estudiado, aún permanece latente la necesidad de aplicar nuevos métodos para su medición desde una perspectiva holística. Esta investigación tiene por objetivo medir la experiencia del turista en Quito mediante el método de evaluaciones sumarias a partir de un set integral de dimensiones e indicadores propuestos en la literatura especializada y su disposición gráfica mediante la matriz de análisis de importancia - desempeño. Para ello se realiza un análisis tanto a nivel descriptivo como inferencial, por medio de los cuales se valida una propuesta teórica de dimensiones e indicadores de la experiencia turística, a la vez que se determina la importancia de las dimensiones y el desempeño percibido en ellas por la demanda, identificando los factores influyentes en la satisfacción del turista. El estudio valida el modelo teórico sometido a contraste empírico y demuestra que la experiencia del turista en Quito es altamente satisfactoria e influenciada por veintiún aspectos clave. Finalmente, la investigación determina que en las dimensiones: unicidad, multisensorialidad, calidad racional y desarrollo personal se equilibran las expectativas de los turistas con lo obtenido durante su viaje; mientras que las dimensiones: desarrollo relacional y responsabilidad se perciben por debajo de sus expectativas.
European Psychiatric Association (EPA) guidance on forensic psychiatry: Evidence based assessment and treatment of mentally disordered offenders
Authors: Völlm Birgit A. , Clarke Martin , Herrando Vicenç Tort , Seppänen Allan O. , Gosek Paweł , Heitzman Janusz , Bulten Erik 
Published: March 2018

AbstractForensic psychiatry in Europe is a specialty primarily concerned with individuals who have either offended or present a risk of doing so, and who also suffer from a psychiatric condition. These mentally disordered offenders (MDOs) are often cared for in secure psychiatric environments or prisons. In this guidance paper we first present an overview of the field of forensic psychiatry from a European perspective. We then present a review of the literature summarising the evidence on the assessment and treatment of MDOs under the following headings: The forensic psychiatrist as expert witness, risk, treatment settings for mentally disordered offenders, and what works for MDOs. We undertook a rapid review of the literature with search terms related to: forensic psychiatry, review articles, randomised controlled trials and best practice. We searched the Medline, Embase, PsycINFO, and Cochrane library databases from 2000 onwards for adult groups only. We scrutinised publications for additional relevant literature, and searched the websites of relevant professional organisations for policies, statements or guidance of interest. We present the findings of the scientific literature as well as recommendations for best practice drawing additionally from the guidance documents identified. We found that the evidence base for forensic-psychiatric practice is weak though there is some evidence to suggest that psychiatric care produces better outcomes than criminal justice detention only. Practitioners need to follow general psychiatric guidance as well as that for offenders, adapted for the complex needs of this patient group, paying particular attention to long-term detention and ethical issues.
Mind the prevalence rate: overestimating the clinical utility of psychiatric diagnostic classifiers
Authors: Abu-Akel Ahmad , Bousman Chad , Skafidas Efstratios , Pantelis Christos 
Published: March 2018

AbstractCurrently, there is an intense pursuit of pathognomonic markers and diagnostic (‘risk-based’) classifiers of psychiatric conditions. Commonly, the epidemiological prevalence of the condition is not factored into the development of these classifiers. By not adjusting for prevalence, classifiers overestimate the potential of their clinical utility. As valid predictive values have critical implications in public health and allocation of resources, development of clinical classifiers should account for the prevalence of psychiatric conditions in both general and high-risk populations. We suggest that classifiers are most likely to be useful when targeting enriched populations.
Politics a “Chilly” Environment for Undergraduate Women in Norway
Authors: Ballen Cissy J. , Lee Dahsol , Rakner Lise , Cotner Sehoya 
Published: March 2018

ABSTRACTGender differences in academic performance and attitudes are widespread in male-stereotyped disciplines but rarely are studied in the social sciences. To assess the extent that gender influences the behavior of undergraduate women in political science, participation was analyzed in a large (N = 130) introductory comparative-politics class at the University of Bergen—a large public university in Norway. In the 2016 fall semester, observers documented classroom behaviors of men and women using a protocol that characterizes types of in-class participation. Findings showed that women participate less than expected given their observed numbers in the classroom. After the semester ended, we provided an opportunity for students to describe why they chose to participate and whether they felt that barriers existed in the classroom that prevented them from expressing their opinions. This article characterizes those responses and presents the first study to draw conclusions about the gendered educational experience in political science by integrating these qualitative and quantitative results.
How can we improve the customers’ experience of our life products?
Authors: Barnard C. R. , Francis K. , Hussain T. , Jumanca C. , Zhang A. 
Published: March 2018

AbstractIn the last three decades the life insurance industry was rocked by a series of mis-selling scandals such as endowment mortgage, personal pension and payment protection insurance mis-selling. Regulators have stepped in to try to address the underlying causes and improve customer protection by introducing more stringent regulation targeted at sales practices and remuneration, product design, disclosure and ongoing monitoring together with significantly larger financial penalties for non-compliance. Against this background, the paper considers whether customers understanding of risks and outcomes associated with life insurance products can be further improved and how poor customer outcomes can be avoided in the future. We acknowledge the complexity of these issues, which involve many stakeholders, covering all stages of the product lifecycle and customer journey and being impacted by a constantly changing regulatory landscape. We first review the current regulatory landscape across both the United Kingdom and other jurisdictions, concluding that whilst regulators have acted to improve customer protection, gaps still remain, particularly around the areas of disclosure and consideration of changing customers’ needs throughout product lifetimes. The paper then considers how the current situation could be improved for customers in a cost effective manner. We focus on improvements in disclosure, needs-based selling, ongoing assessment and communication as a means of ensuring that products continue to meet the customers’ needs and risk profile, and on introducing a duty of care which would force financial services firms to act in the best interests of their customers. In this paper we present our preliminary thoughts and recommendations. Some of the recommendations will cost something to implement, and should therefore be supported by cost-benefit analyses that would weigh these costs against the potentially larger benefits to both customers and the insurance industry.
Hierarchical thermal network analysis of axial‐flux permanent‐magnet synchronous machine for electric motorcycle
Authors: Chen Qixu , Liang Deliang , Gao Lin , Wang Qingshan , Liu Yibin 
Published: March 2018

A novel 24 kW 12‐slots/10‐poles axial‐flux permanent‐magnet synchronous machine (AFPMSM) with external rotor motor applied to the large electric motorcycle is introduced in this study, which has the characteristics of the yokeless and segmented armature for power density improvement. The hierarchical method is used for calculation of stator iron core loss based on the analytical solution of air‐gap flux density, which cuts the prototype into many equivalent linear motor slices in the circumferential direction. A major advantage of hierarchical methods over traditional iron core loss calculation is its higher accuracy and rapidity. Then a lumped parameter T‐type thermal network model is presented for AFPMSM temperature rise calculation. A 3D liquid–solid coupling model is compared with the 2D T‐type lumped parameter thermal network. Finally, a temperature rise measurement platform is established to verify the above‐mentioned methods. Testing result shows that the hierarchical method and T‐type thermal network have a higher accuracy to predict each part temperature.
Die dentolabiale Ästhetik
Authors: Mansour Sonia , Pospiech Peter 
Published: March 2018

ZusammenfassungIn einer Welt, in der Ästhetik und äußeres Aussehen immer bedeutender werden, spielt insbesondere die Schönheit der Zähne in den Vorstellungen der Patienten eine dominante Rolle, was sich als Leistungsangebot und auch wesentlicher Bestandteil der meisten Praxishomepages widerspiegelt. Gutes Aussehen steht in direktem Zusammenhang mit einem attraktiven Lächeln und schönen Zähnen und damit einer gesteigerten Lebensqualität.
Effects of (Pre-)analytical Variables on Activated Protein C Resistance Determined Via a Thrombin Generation-based Assay
Authors: Curvers Joyce , Christella M. , Thomassen G. D. L. , de Ronde Hans , Bertina Rogier , Rosendaal Frits , Tans Guido , Rosing Jan 
Published: March 2018

SummaryThe normalized activated protein C sensitivity ratio (nAPC-sr) determined with an assay that quantifies the effect of APC on thrombin formation initiated via the extrinsic coagulation pathway identifies hereditary and acquired defects of the protein C system. We investigated the influence of assay conditions (analytical variables) and plasma handling (pre-analytical variables) on nAPC-sr obtained with this APC resistance test. The effect of the analytical variables (CaCl2, phospholipid and APC concentrations and the concentration and source of tissue factor) was determined in pooled normal plasma. Inhibition of thrombin formation by APC was dependent on the APC concentration and was also affected by the tissue factor, Ca2+ and phospholipid concentrations. Thus, strict standardization of reactant concentrations is required to obtain reproducible nAPC-sr. Three different tissue factor preparations were compared by determining nAPCsr in plasma samples obtained from 90 healthy individuals. nAPC-sr were similar for all three tissue factor preparations although, compared with the noncommercially available tissue factor used in earlier studies, values determined with commercial tissue factor preparations showed larger variation. Pre-analytical variables, investigated in plasma of nine volunteers (3 normal individuals and 6 individuals with an APCresistant phenotype) were: concentration of anticoagulant (3.2% vs. 3.8% trisodiumcitrate), time before processing of blood (0, 4 and 24 h), centrifugation speed, storage temperature of plasma (–20° C vs. –80° C) and sample thawing. Multiple linear regression analysis showed that only the citrate concentration affected the nAPC-sr, which was higher in samples collected in 3.2% trisodiumcitrate than in samples collected in 3.8% trisodiumcitrate.
A Prospective Evaluation of the Heat Shock Protein 70 Gene Polymorphisms and the Risk of Stroke
Authors: Bates David , Ridker Paul , Zee Robert 
Published: March 2018

SummaryGenetic polymorphisms of heat shock protein 70-kD (HSP70) gene family have recently been hypothesized to be risk factors for cerebral ischemia. However, no prospective epidemiological data evaluating this gene family are available. The present investigation was conducted to examine the possible associations between the HSP70-1 nucleotide 190, HSP70-2 nucleotide 1267, and HSP70-hom nucleotide 2437 polymorphisms and the incidence of stroke in a large cohort of initially healthy men. 14916 apparently healthy men were followed over a 12-year period for incident stroke. Employing a nested case-control study design, 338 study participants who developed stroke (cases) and 338 ageand smoking-matched study participants who remained healthy during follow-up (controls) were evaluated. All observed genotype frequencies were in Hardy-Weinberg equilibrium. The allele and genotype distributions of the polymorphisms tested were similar among cases and controls, such that the relative risk of future stroke was 0.89 for HSP70-1 nucleotide 190 (95%CI = 0.70–1.12; p = 0.31), 1.13 for HSP70-2 nucleotide 1267 (95%CI = 0.90–1.42; p = 0.29); and 0.89 for HSP70-hom nucleotide 2437 (95%CI = 0.65–1.21; p = 0.45), assuming an additive model. No evidence of association was observed assuming dominant or recessive mode of inheritance. In this large, prospective study, genetic polymorphisms in the HSP70 genes were not associated with risks of future stroke. Screening for these polymorphisms is unlikely to be a useful tool for risk assessment.
Fibrinogen Assembly and Crosslinking on a Fibrin Fragment E Template
Authors: Siebenlist Kevin , Hernandez Irene , Wall Joseph , Hainfeld James , Mosesson Michael 
Published: March 2018

SummaryThere is an ongoing controversy concerning whether crosslinked γ chains in fibrin are oriented “transversely” between fibril strands or “end-to-end” along fibril strands. From the latter viewpoint, Veklich et al. [Proc Natl Acad Sci (USA) 95: 1438, 1998] observed that fibrinogen fibrils that had been assembled on a fibrin fragment E template, crosslinked with factor XIIIa, and then dissociated in acetic acid solution, were aligned end-to-end. This led to the conclusion that crosslinked γ chains in fibrin under physiological conditions were also aligned endto-end. To assess its validity we studied the assembly and organization of fibrinogen molecules on a des AB-fibrin fragment E (E-des AB) or a des A-fibrin fragment E (E-des A) template.We evaluated the roles of E polymerization sites EA and EB, and D association sites γXL, Da, Db, βC, and αC in this process. EA:Da interactions caused fibrinogen: E “DED” complexes to form, and markedly enhanced the γ chain crosslinking rates of fibrinogen or des αC-fibrinogen. Fibrinogen crosslinking without added fibrin E was slower, and that of des αC-fibrinogen was still slower. These events showed that although αC domains promote fibrinogen fibril assembly and crosslinking, they contribute little to increasing the EA:Da-dependent crosslinking rate. Electron microscopic (STEM) images of E-des AB and fibrinogen plus factor XIIIa showed single-, double-, and multistranded fibrils with interstrand DED complexes aligned side-to-side. This alignment was due to βC:βC contacts resulting from D subdomain rearrangements initiated by the EB:Db interactions, and also occurred in mixtures of des αC-fibrinogen with E-des AB.In contrast, a mixture of fibrinogen and E-des A plus XIIIa revealed double-stranded fibrils with interstrand DED complexes in a halfstaggered arrangement, an alignment that we attribute to crosslinking of γXL sites bridging between fibrils strands. These and other features of E-des A-based fibrinogen fibrils, including interstrand γ chain bridges and early and extensive lateral fibril strand associations concomitant with accelerated γ chain crosslinking, indicate that crosslinking of fibrin fibril strands takes place preferentially on transversely positioned γ chains.
Long-term Persistence of Anti-factor VIII Antibody-secreting Cells in Hemophilic Mice after Treatment with Human Factor VIII
Authors: Hausl Christina , Maier Elisabeth , Ahmad Rafi , Turecek Peter , Dorner Friedrich , Reipert Birgit , Schwarz Hans 
Published: March 2018

SummaryThe analysis of anti-factor VIII (FVIII) antibody-secreting cells (ASC) at different anatomic sites provides valuable information about the nature of the anti-FVIII immune response in hemophilic mice after treatment with human FVIII. An Elispot system is described that is suitable for analyzing frequencies and IgG subclasses of anti-FVIII ASC at the single-cell level. Hemophilic mice were treated with four doses of FVIII. Anti-FVIII antibodies in blood as well as anti-FVIII ASC in spleen and bone marrow were analyzed after each dose of FVIII and subsequently up to 22 weeks after termination of the FVIII treatment. Anti-FVIII ASC first appeared in the spleen where they were detectable after two intravenous doses of FVIII. Their appearance correlated with that of anti-FVIII antibodies in blood plasma. Anti- FVIII ASC in bone marrow were detectable after three doses of FVIII and were probably cells that initially formed in the spleen and subsequently migrated to the bone marrow. Whereas the frequency of anti- FVIII ASC in the spleen increased up to the fourth dose of FVIII and declined thereafter, in the bone marrow it remained constant for up to at least 22 weeks after the termination of the FVIII treatment. Titers of anti-FVIII antibodies in blood plasma increased up to the fourth dose of FVIII, then remained high constantly for 14 weeks and decreased but the antibodies were still detectable for up to at least 22 weeks after the fourth dose of FVIII. The IgG-subclass distribution of anti-FVIII ASC was similar in spleen and bone marrow and matched the subclasses of anti-FVIII antibodies in blood plasma indicating that both organs contribute to circulating antibodies in the blood.
Differential Regulation of Human Platelet Responses by cGMP Inhibited and Stimulated cAMP Phosphodiesterases
Authors: Manns J. M. , Brennan K. J. , Sheth S. B. , Colman R. W. 
Published: March 2018

SummaryPlatelets contain two cAMP phosphodiesterases (PDEs) which regulate intracellular cAMP levels, cGMP-inhibited cAMP PDE (PDE3A) and cGMP-stimulated PDE (PDE2A). Using the PDE3 inhibitor, milrinone and the PDE2 inhibitor, erythro-9-(2-hydroxyl-3-nonyl)adenine (EHNA), we have explored the contribution of each PDE to the regulation of platelet function. Inhibition of PDE2 resulted in higher levels of intracellular cAMP than inhibition of PDE3A suggesting this PDE may be the more important regulator of cAMP in human platelets. However, a concentration-dependent inhibition of agonist-induced aggregation was observed with milrinone while little effect was seen with EHNA. In addition, we observed a concentration-dependent inhibition in the increase of intracellular Ca2+ with PDE3 inhibition and significantly less with PDE2 inhibition. PDE3 inhibition also resulted in a concentration-dependent increase in cAMP-mediated phosphorylation of the vasodilator-stimulated phospho-protein (VASP) whereas there was no significant increase with PDE2 inhibition. In each of these experiments, synergism was noted with the combination of milrinone and EHNA. These results suggest that cAMP pools may be localized and the various PDEs regulate specific pools. These data also suggest that inhibitors of PDE3A may be more effective antiplatelet agents.