bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isopod distribution and climate change
Authors: Sfenthourakis Spyros , Hornung Elisabeth 
Published: December 2018

The unique properties of terrestrial isopods regarding responses to limiting factors such as drought and temperature have led to interesting distributional patterns along climatic and other environmental gradients at both species and community level. This paper will focus on the exploration of isopod distributions in evaluating climate change effects on biodiversity at different scales, geographical regions, and environments, in view of isopods’ tolerances to environmental factors, mostly humidity and temperature.
Isopod distribution is tightly connected to available habitats and habitat features at a fine spatial scale, even though different species may exhibit a variety of responses to environmental heterogeneity, reflecting the large interspecific variation within the group.
Furthermore, isopod distributions show some notable deviations from common global patterns, mainly as a result of their ecological features and evolutionary origins. Responses to human disturbance are not always traceable, but a trend towards community homogenisation is often found under strong global urbanisation processes.
In general, even though it is still not clear how predicted climate change will affect isopod distribution, there is evidence that mixed effects are to be expected, depending on the region under study.
We still lack robust and extensive analyses of isopod distributions at different scales and at different biomes, as well as applications of distribution models that might help evaluate future trends.
Cytomegaloviral or Pneumocystis Jiroveci Pneumonia Increases Mortality in Systemic Lupus Erythematosus Patients with Pulmonary Hemorrhage: Evidence from Bronchoalveolar Lavage Fluid
Authors: Sun Yi-Syuan , Huang De-Feng , Lin Fang-Chi , Hsu Chih-Kai , Sun I-Ting , Chang Shi-Chuan , Tsai Chang-Youh , Lai Chien-Chih 
Published: December 2018

Objective.To evaluate the role of cytomegaloviral or Pneumocystis jiroveci pneumonia (CMV/PJP) in systemic lupus erythematosus (SLE) patients with pulmonary hemorrhage (PH).Methods.We retrospectively examined hospital records for 27 SLE patients with PH who received bronchoalveolar lavage fluid (BALF) analyses. Clinical profile and mortality rates were compared between groups with and without CMV/PJP. Risk factors for PH-related mortality were analyzed.Results.Among 27 SLE patients with PH, 15 had pathogens from BALF samples, and 8 had CMV/PJP. Although CMV/PJP was treated, the RR for 90- and 180-day mortality rates of SLE patients with CMV/PJP were higher than those without these infections (5.94, 95% CI 1.44–24.48; 7.13, 95% CI 1.81–28.06, respectively). Risk factors for 90- and 180-day mortality were presence of CMV/PJP (OR 14.2, 95% CI 1.83–109.9; OR 25.5, 95% CI 2.91–223.3, respectively) and use of pulse methylprednisolone for PH treatment (OR 12.0, 95% CI 1.48–97.2; OR 8.5, 95% CI 1.13–63.9, respectively). Factors increasing the 90-day mortality rate were duration of mechanical ventilation exceeding 14 days (OR 11.1, 95% CI 1.11–112.0) and use of aggressive immunosuppression close to PH onset (OR 7.56, 95% CI 1.09–52.4). Three of the 7 patients receiving aggressive immunosuppression died with the presence of CMV/PJP.Conclusion.Owing to the high prevalence of CMV/PJP and its association with mortality, routine BALF analysis is recommended for all suitable SLE patients with PH. Use of aggressive immunosuppression does not benefit SLE patients with opportunistic infections during PH attack.
Smoking Is Associated with Higher Disease Activity in Rheumatoid Arthritis: A Longitudinal Study Controlling for Time-varying Covariates
Authors: Gianfrancesco Milena A. , Trupin Laura , Shiboski Stephen , van der Laan Mark , Graf Jonathan , Imboden John , Yazdany Jinoos , Schmajuk Gabriela 
Published: December 2018

Objective.Prior studies around the relationship between smoking and rheumatoid arthritis (RA) disease activity have reported inconsistent findings, which may be ascribed to heterogeneous study designs or biases in statistical analyses. We examined the association between smoking and RA outcomes using statistical methods that account for time-varying confounding and loss to followup.Methods.We included 282 individuals with an RA diagnosis using electronic health record data collected at a public hospital between 2013 and 2017. Current smoking status and disease activity were assessed at each visit; covariates included sex, race/ethnicity, age, obesity, and medication use. We used longitudinal targeted maximum likelihood estimation to estimate the causal effect of smoking on disease activity measures at 27 months, and compared results to conventional longitudinal methods.Results.Smoking was associated with an increase of 0.64 units in the patient global score compared to nonsmoking (p = 0.01), and with 2.58 more swollen joints (p < 0.001). While smoking was associated with a higher clinical disease activity score (2.11), the difference was not statistically significant (p = 0.22). We found no association between smoking and physician global score, or C-reactive protein levels, and an inverse association between smoking and tender joint count (p = 0.05). Analyses using conventional methods showed a null relationship for all outcomes.Conclusion.Smoking is associated with higher levels of disease activity in RA. Causal methods may be useful for investigations of additional exposures on longitudinal outcome measures in rheumatologic disease.
Les plateformes numériques
Authors: Perrot Anne 
Published: December 2018

Les technologies numériques, présentes depuis des décennies, ont pris un virage décisif avec la combinaison de la géolocalisation et du big data . L’intelligence artificielle, nouveau développement des avancées du numérique, est en passe de pouvoir se substituer à la créativité humaine dans bon nombre de cas. Cette révolution pose de nombreuses questions pour le développement économique et social : les robots vont-ils remplacer les emplois humains, ou bien sont-ils complémentaires à ceux-ci ? Faut-il réguler les grandes plateformes numériques ? Comment protéger les données personnelles ? Cet article tente d’éclairer certaines des questions de politiques publiques posées par la transformation numérique.
Facebook, Twitter, Youtube
Authors: Theviot Anaïs 
Published: December 2018

À l’ère du big data et de la télévision numérique, les candidats ne peuvent plus communiquer de la même façon qu’ils le faisaient en 1965, quand n’existait qu’une seule chaîne de télévision. En cinquante ans, les campagnes pour l’élection présidentielle française, inspirées du modèle américain, se sont clairement industrialisées, technicisées, médiatisées et numérisées. Pourtant, peut-on réellement parler d’une révolution numérique dans la participation et l’engagement politique ?
Ce que les techniques numériques font aux loisirs
Authors: Coavoux Samuel 
Published: December 2018

Le « tournant numérique » des pratiques culturelles suscite espoirs et craintes. Cet article passe en revue des travaux empiriques récents pour replacer ces évolutions dans la longue durée. Il examine les fluctuations limitées de la diversité des consommations culturelles, et met en évidence des enjeux souvent inaperçus, notamment la manière dont le numérique équipe d’autres mondes de loisirs, apparemment peu susceptibles d’être virtualisés, comme le tricot.
Les Algériens à Montluc. Militarisation de la répression en France durant la guerre d’indépendance algérienne (1954-1962)
Authors: André Marc 
Published: December 2018

La guerre d’indépendance algérienne est la seule guerre de décolonisation qui a eu lieu à la fois dans la colonie et sur le territoire métropolitain. Or, jusqu’à présent, les études historiques se sont principalement concentrées sur Paris et la répression policière de l’activisme algérien, laquelle culmine avec le massacre du 17 octobre 1961. La publication, depuis 1962, de plusieurs écrits autobiographiques rédigés par d’anciens militants du FLN, condamnés à mort par le Tribunal permanent des forces armées de Lyon, invite à réorienter les analyses sur la province et notamment sur Lyon. Au carrefour d’une histoire de la justice, du carcéral et du militaire, cet article propose alors, à partir du cas Montluc (une caserne, un tribunal militaire, une prison), une histoire sociale de la justice militaire et de l’incarcération des Algériens en métropole durant la guerre d’indépendance algérienne, une histoire de ceux qui la pratiquent comme de ceux qui la subissent. Il repose sur des sources très variées dont les dossiers de procédures judiciaires conservés aux archives de la justice militaire, les actes de jugements ordonnés dans des séries statistiques, des entretiens oraux menés auprès d’avocats ou d’anciens condamnés à mort algériens, des rapports ministériels conservés aux archives nationales ou départementales, des dossiers d’inhumations conservés dans les archives des cimetières lyonnais. Au fil des lectures, il apparaît que le militaire a aussi joué sa partie en métropole.
La parenté par les femmes : bâtards et affins de maîtresses royales ( xvii e - xviii e siècles)
Authors: Leroux Flavie 
Published: December 2018

Lorsqu’ils retiennent l’attention des historiens, les bâtards des rois de France sont étudiés dans une perspective politique, pour éclairer la construction, le fonctionnement voire les failles de la monarchie. Ils sont ainsi regardés au travers de leur rattachement à la branche royale – donc paternelle. Cet article se propose de retourner l’approche, en examinant les bâtards royaux dans les rapports qu’ils peuvent entretenir avec leurs affins du côté maternel, sur une période s’étendant du début du XVII e siècle à la seconde moitié du XVIII e siècle. Sans pour autant négliger les aspects politiques qu’implique le positionnement particulier de ces individus dans la famille royale, l’enjeu est surtout d’interroger la manière dont ils peuvent faire parenté, malgré leur rang différencié et l’illégitimité de leurs liens. Il s’agit donc, plus généralement, d’observer des dynamiques familiales inédites, dont les fondements sont à l’opposé de ceux sur lesquels s’appuie ordinairement la noblesse lignagère. Pour les appréhender, plusieurs approches sur les liens interpersonnels, tels que l’étude du clientélisme, l’histoire sociale ou l’anthropologie, peuvent être appelées et éprouvées. À cette fin, une documentation variée a été mobilisée, en premier lieu les minutes de notaires, mais également les actes issus de la chancellerie royale et les écrits produits par les contemporains.
Repenser la Glorieuse Révolution de 1688
Authors: Ghorbal Karim 
Published: December 2018

1688. The First Modern Revolution , ouvrage de Steven Pincus paru en 2009, réinterprète d’une manière nouvelle et ambitieuse les évènements qui constituèrent la Glorieuse Révolution anglaise de 1688-1689. Ouvrage remarqué et commenté par les historiens anglo-saxons, il est néanmoins passé inaperçu au sein de la communauté historique française, alors même que la thèse qu’il présente rapproche l’histoire révolutionnaire de l’Angleterre de celle de la France. Selon lui, loin d’être pacifique, raisonnable ou conservatrice, la Glorieuse Révolution fut violente, populaire et radicale, et le conflit entre Jacques II et Guillaume d’Orange opposa non pas les réactionnaires aux progressistes ou les catholiques aux protestants, mais bien plutôt deux projets modernisateurs antagonistes. Celui de Jacques II épousait celui des tories, et souhaitait créer un État absolutiste catholique moderne, fondé sur un empire terrestre étendu, un armée forte, une administration efficace et une agriculture développée. Celui de Guillaume d’Orange et de ses partisans whigs préconisait au contraire la création d’un empire commercial et maritime s’appuyant sur la production manufacturière. S. Pincus rompt dès lors avec la vision exceptionnaliste de la Glorieuse Révolution qui a longtemps prévalu en Angleterre et aux États-Unis. Pour lui, cette révolution doit être en réalité comprise comme la première révolution moderne, comparable à bien des égards aux révolutions ultérieures, française, russe, chinoise ou iranienne.
NLRP10 Affects the Stability of Abin-1 To Control Inflammatory Responses
Authors: Mirza Nora , Sowa Anna S. , Lautz Katja , Kufer Thomas A. 
Published: December 2018

Abstract
NOD-like receptors (NLR) are critical regulators of innate immune signaling. The NLR family consists of 22 human proteins with a conserved structure containing a central oligomerization NACHT domain, an N-terminal interaction domain, and a variable number of C-terminal leucine-rich repeats. Most NLR proteins function as cytosolic pattern recognition receptors with activation of downstream inflammasome signaling, NF-κB, or MAPK activation. Although NLRP10 is the only NLR protein lacking the leucine rich repeats, it has been implicated in multiple immune pathways, including the regulation of inflammatory responses toward Leishmania major and Shigella flexneri infection. In this study, we identify Abin-1, a negative regulator of NF-κB, as an interaction partner of NLRP10 that binds to the NACHT domain of NLRP10. Using S. flexneri as an infection model in human epithelial cells, our work reveals a novel function of NLRP10 in destabilizing Abin-1, resulting in enhanced proinflammatory signaling. Our data give insight into the molecular mechanism underlying the function of NLRP10 in innate immune responses.
Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues
Authors: Sorrelle Noah , Ganguly Debolina , Dominguez Adrian T. A. , Zhang Yuqing , Huang Huocong , Dahal Lekh N. , Burton Natalie , Ziemys Arturas , Brekken Rolf A. 
Published: December 2018

Abstract
Immune profiling of tissue through multiplex immunohistochemistry is important for the investigation of immune cell dynamics, and it can contribute to disease prognosis and evaluation of treatment response in cancer patients. However, protocols for mouse formalin-fixed, paraffin-embedded tissue have been less successful. Given that formalin fixation and paraffin embedding remains the most common preparation method for processing mouse tissue, this has limited the options to study the immune system and the impact of novel therapeutics in preclinical models. In an attempt to address this, we developed an improved immunohistochemistry protocol with a more effective Ag-retrieval buffer. We also validated 22 Abs specific for mouse immune cell markers to distinguish B cells, T cells, NK cells, macrophages, dendritic cells, and neutrophils. In addition, we designed and tested novel strategies to identify immune cells for which unique Abs are currently not available. Last, in the 4T1 model of breast cancer, we demonstrate the utility of our protocol and Ab panels in the quantitation and spatial distribution of immune cells.
Model Kepemimpinan Servant Paling Dominan Berhubungan dengan Kinerja
Authors: Rayatin Lilis 
Published: December 2018

Model kepemimpinan kepala ruangan dapat meningkatkan kinerja perawat pelaksana dalam memberikan asuhan keperawatan. Tujuan penelitian ini adalah untuk mengidentifikasi hubungan antara model kepemimpinan kepala ruangan dengan kinerja perawat pelaksana. Metode penelitian menggunakan cross sectional, dengan melibatkan 141 responden di sebuah RS. Instrumen yang digunakan adalah instrumen model kepemimpinan yang pernah digunakan sebelumnya. Model kepemimpinan yang berhubungan dengan kinerja adalah servant, visioner, dan transaksional. Model kepemimpinan yang paling dominan berhubungan dengan kinerja adalah servant (p= 0,0001; α= 0,05; CI: 2,733–11,853; Odd Ratio: 5,691). Kepala ruangan yang dipersepsikan oleh perawat pelaksana menggunakan model kepemimpinan servant berpeluang meningkatkan kinerja perawat pelaksana sebesar 5 kali lebih tinggi dibandingkan dengan yang tidak dipersepsikan menggunakan model kepemimpinan servant. Hasil penelitian ini merekomendasikan kepada pimpinan Rumah sakit khususnya untuk kepala ruangan dapat menggunakan model kepemimpinan servant dalam peran dan fungsinya untuk meningkatkan kinerja perawat pelaksana. Kata kunci: Kinerja perawat pelaksana, Model kepemimpinan servant. Abstract Head Nurse Leadership Model Can Improve The Performance of Nurses in Providing Nursing Care. The purpose of this study was to identify the correlation between the head nurse leadership model and the nurses’ performance. This study applied a cross-sectional method and involved 141 nurses at a Hospital. This study used the instruments was developed in the other studies. The results showed that the leadership model related to the performance was a servant, visionary, and transactional. The most dominant leadership model related to the performance was servant (p= 0.0001; α= 0.05, CI: 2.733 to 11.853; odds ratio: 5.691). Head nurses that were perceived by nurses as using the servant leadership model had an opportunity to improve the nurses’ performance five times higher than those who were not perceived as using the servant leadership model. It is recommended that the head of Hospitals, especially the head nurses, to apply the servant leadership model in their roles and functions to improve the nurses’ performance. Keywords: Nurses’ performance, Servant Leadership model
PENGARUH PERLUASAN MEREK TERHADAP CITRA MEREK (STUDI PADA FRESTEA-FRESTEA GREEN)
Authors: Santoso Radityo Kusumo , Grataridarga Niko 
Published: December 2018

Dengan berkembangnya trend masyarakat mengenai kebutuhan akan minimum yang menyehatkan, mendorong produsen minuman menjawab trend tersebut dengan mengeluarkan produk baru, dimana didalam peluncuran produk baru tersebut selain mengenalkan produk baru produsen juga sekaligus ingin menciptakan ekuitas merek yang kuat. Oleh sebab itu, produsen menggunakan perluasan merek. Tujuan dari penelitian ini untuk menganalisis pengaruh perluasan merek terhadap citra merek. Penelitian ini merupakan penelitian dengan pendekatan kuantitatif dengan analisis eksplanasi dan regresi linier berganda, instrumen yang peneliti gunakan adalah kuesioner. Berdasarkan hasil penelitian menyatakan bahwa satu dari lima dimensi yaitu : perceived quality, secara signifikan mempengaruhi citra merek, sedangkan keempat dimensi lainnya tidak mempengaruhi secara signifikan. Hasil analisa menunjukkan bahwa perluasan merek mempengaruhi citra merek sebesar 59.7%, sedangkan sisanya sebesar 40.3% dipengaruhi oleh variabel lain. Kata kunci : Perluasan merek, Citra merek, regresi berganda
Implementasi Sosialisasi Peraturan Pemerintah No. 23 Tahun 2018 Bagi Pelaku Usaha Mikro, Kecil Dan Menengah (UMKM)
Authors: - Hendri 
Published: December 2018

Usaha Mikro, Kecil dan Menengah (UMKM) yang berkembang begitu pesat dari tahun ke tahun telah menimbulkan kewajiban perpajakan bagi pelaku usaha tersebut. Untuk membantu Wajib Pajak UMKM pemerintah pada tahun 2013 telah mengeluarkan Peraturan Pemerintah (PP) nomor 46. Setelah beberapa tahun dilaksanakan kini pemerintah telah mengeluarkan penyempurnaan dari peraturan tersebut yakni dengan mengeluarkan PP No. 23 Tahun 2018. Peraturan ini dikeluarkan untuk memberikan keringanan tarif bagi para pelaku usaha UMKM. Namun PP yang disahkan pada pertengahan tahun 2018 ini dirasakan masih kurang sosialisasi kepada para wajib pajak. Penelitian ini berfokus pada pemahaman para wajib pajak terkait implementasi aturan tersebut.Kata kunci: Pajak, UMKM, Peraturan Pemerintah, Implementasi dan Sosialisasi
Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2
Authors: Ruiz Mario , Bodhicharla Rakesh , Svensk Emma , Devkota Ranjan , Busayavalasa Kiran , Palmgren Henrik , Ståhlman Marcus , Boren Jan , Pilon Marc 
Published: December 2018

Dietary fatty acids are the main building blocks for cell membranes in animals, and mechanisms must therefore exist that compensate for dietary variations. We isolated C. elegans mutants that improved tolerance to dietary saturated fat in a sensitized genetic background, including eight alleles of the novel gene fld-1 that encodes a homolog of the human TLCD1 and TLCD2 transmembrane proteins. FLD-1 is localized on plasma membranes and acts by limiting the levels of highly membrane-fluidizing long-chain polyunsaturated fatty acid-containing phospholipids. Human TLCD1/2 also regulate membrane fluidity by limiting the levels of polyunsaturated fatty acid-containing membrane phospholipids. FLD-1 and TLCD1/2 do not regulate the synthesis of long-chain polyunsaturated fatty acids but rather limit their incorporation into phospholipids. We conclude that inhibition of FLD-1 or TLCD1/2 prevents lipotoxicity by allowing increased levels of membrane phospholipids that contain fluidizing long-chain polyunsaturated fatty acids.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (<xref ref-type="decision-letter" rid="SA1">see decision letter</xref>).
NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients
Authors: Thiam Alassane , Baaklini Sabrina , Mbengue Babacar , Nisar Samia , Diarra Maryam , Marquet Sandrine , Fall Mouhamadou Mansour , Sanka Michel , Thiam Fatou , Diallo Rokhaya Ndiaye , Torres Magali , Dieye Alioune , Rihet Pascal 
Published: December 2018

Background
Host factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 polymorphism (rs2736191) lying within this region was found to be associated with mild malaria.

Methods
Blood samples were taken from 188 Plasmodium falciparum malaria patients (76 mild malaria patients, 85 cerebral malaria patients, and 27 severe non-cerebral malaria patients). NCR3-412 (rs2736191) was analysed by sequencing, and haematological parameters were measured. Finally, their association with clinical phenotypes was assessed.

Results
We evidenced an association of thrombocytopenia with both cerebral malaria and severe non-cerebral malaria, and of an association of high leukocyte count with cerebral malaria. Additionally, we found no association of NCR3-412 with either cerebral malaria, severe non-cerebral malaria, or severe malaria after grouping cerebral malaria and severe non-cerebral malaria patients.

Conclusions
Our results suggest that NCR3 genetic variation has no effect, or only a small effect on the occurrence of severe malaria, although it has been strongly associated with mild malaria. We discuss the biological meaning of these results. Besides, we confirmed the association of thrombocytopenia and high leukocyte count with severe malaria phenotypes.