bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunológiai eltérések kimutatása laboratóriumi módszerekkel primer immunhiányos betegségekben
Authors: Nagy Gábor 
Published: December 2018

Abstract: In primary immunodeficiencies, the malfunction of the immune system is caused by genetic alterations. The physician proposes the most probable diagnosis based on symptoms, clinical signs, the family history and the results of the pathogen identification. To confirm this clinical suspicion, it is essential that the immunological malfunction be tested using in vitro diagnostic procedures. This paper summarizes the screening, confirmatory and disease-specific laboratory methods capable of testing the antibody response, the T cells, the phagocytic function, the complement system and other components of the innate immune system. The genetic tests necessary to make the final diagnosis are beyond the scope of this publication. Orv Hetil. 2018; 159(49): 2087–2094.
Légzőszervi megbetegedések primer immundefektusokban
Authors: Nyul Zoltán 
Published: December 2018

Abstract: The respiratory infections are the most common presentations and leading cause of morbidity and mortality in primary immunodeficiencies. The pathogen or spectrum of pathogens may be characteristic for the underlying primary immunodeficiency, and that knowledge plays an important role in the empirical treatment or prevention of the infections, or, conversely, the identification of an unusual pathogen may raise the suspicion on an immunodeficiency. Apart from the acute respiratory infections, chronic lung diseases are also common complications. The recurrent infections result in bronchiectasis, an irreversible structural damage of the respiratory tract, that frequently serve as locus for subsequent infections. The other group of chronic pulmonary complications are the interstitial lung diseases, which seem to be independent from infections and can be regarded as the pulmonary manifestation of the immune dysregulation. It is important to identify those patients with immunodeficiency who are at increased risk of secondary lung complications and to regularly screen this group for the early detection of the pulmonary complications. Orv Hetil. 2018; 159(49): 2043–2049
KADIN ÇALIŞANLARIN TOPLUMSAL CİNSİYET ALGILARI VE İŞE ADANMIŞLIKLARI ARASINDAKİ İLİŞKİ
Authors: YENER Serdar , DEMİRTAŞ Özgür 
Published: December 2018

Toplumsal
cinsiyet algısı bireylerin toplumdaki görev, sorumluluk ve kendilerinden olan
beklentileri belirleyen cinsiyet
normlarına dayanır. Toplumsal cinsiyet algısı kadınların yaşamın farklı
alanlarındaki sorumluluklarını yerine getirmede kullandıkları referans olarak
tanımlanmaktadır. İş yaşamı toplumsal cinsiyet algısının etkin olarak
hissedildiği bir alan olarak kadınların yaşamında bir yer kapsamaktadır. Çalışanların adanmışlıklarının
işletmenin performansını etkilediği gözönüne alındığında işgücünün büyük bir
kısmını oluşturan kadın çalışanların adanmışlarının toplumsal cinsiyet algısı
tarafından etkilenebileceği düşünülmüştür. Yayılım kuramı (Spillover Theory)
çerçevesinde kurulan modelin araştırılması için
Sinop il ve ilçelerinde kamu ve
özel sektörde ücretli çalışan kadınlardan oluşan örneklem kullanılmıştır.
Örneklemden toplanan veriler bir istatistik programı ile analiz edilmiştir.
Regresyon sonuçlarına göre toplumsal cinsiyet algısının adanmışlığı etkilediği
görülmüştür.
HİTİT UYGARLIĞINDA BÜYÜK TAPINAK MİMARİSİ VE ETKİLERİ
Authors: SALİHOĞLU Elif Fatma , DEMİRARSLAN Deniz 
Published: December 2018

Eski
Anadolu Uygarlıklarından olan Hititler ;Anadolu’nun mimari ve sanatına yön
veren en önemli uygarlıkların başını çekmektedir. Bu uygarlık ilk kez 1834
yılında Hitit başkenti Hattuşaş ile Charles Texier tarafından Dünya’ya
tanıtılmıştır. Bir dağ kenti olan Hattuşaş yer seçimi açısından dahi kendi
dönemi içerisinde Anadolu’da özgün bir başkent konumundadır. Yüzyıllar
içerisinde yapılan arkeolojik çalışmalar ile burada taş temelleri günümüze
kadar ulaşmış olan görkemli bir kentin mimarisini ortaya çıkarmıştır. Bu
çalışma ile Hattuşaş’ta yer alan ve en önemli mimari yapıların başında gelen Büyük
Tapınak Kompleksi’nin mekân kurgusu incelenmiş olup; Anadolu Mimarlığı
üzerindeki etkileşimlerine ulaşılması amaçlanmıştır. Yapılan
araştırmalar göstermiştir ki; Büyük Tapınak bir mabet olmasının yanı sıra iş
evi, arşiv odası gibi farklı işlevlere sahip mekanlar da barındıran büyük bir
komplekstir. Dini tören ritüellerine uygun olarak tapınak alanlarında mahrem
alanların ve kutsal bölümlerin oluşturulması, özel avlu ve girişler, depolama
alanları akılcı bir tasarımın göstergesidir. Yatayda genişleyen ve işlevlerine
göre bölümlere ayrılan mekân kurgusu, işlevlik, çevreye hâkim konumu ve malzeme
seçimleri ile örnek bir mimari yapıdır. Anadolu’da Hitit mimarisinden çok daha
yakın tarihli inşa edilmiş olan Selçuklu-Osmanlı külliyeleri ve Topkapı
Sarayı’nın da Hitit mimarisinin plan özelliklerini gösterdiği görülmüştür. Sonuç
olarak Hitit Uygarlığı mimari ve sanatının Anadolu mimari kimliğinin
oluşmasında önemli bir rol oynadığı bir kez daha ortaya konmuştur.
FEN ÖĞRETİMİNDE HARMANLANMIŞ ÖĞRENME: AVANTAJLAR VE ÖĞRENCİ ALIŞKANLIKLARI
Authors: YILMAZ Özkan 
Published: December 2018

Sınıf içi yüz yüze öğretim ve uzaktan öğretimin kendine özgü avantaj ve dezavantajları bulunmaktadır. Harmanlanmış öğrenme her iki öğrenme ortamının avantajlı yönlerinin kullanımını esas almaktadır. Bu araştırma, harmanlanmış öğrenmenin öğrencilere sağladığı avantajları belirlemeye yönelik bir anket çalışmasıdır. Çalışma yükseköğretim seviyesinde, okul öncesi öğretmenliği bölümünde öğrenim gören öğrencilerle yürütülmüştür. Fen Eğitimi dersi kapsamında yapılan harmanlanmış öğrenme uygulamasına katılan 33 öğrenci hazırlanan ankete katılmıştır. Veri toplama aracı olarak kullanılan anket iki temel bölümden oluşmaktadır. Birinci bölüm harmanlanmış öğrenmenin avantajlarını belirlemeyi (11 madde), ikinci bölüm ise uzaktan öğretim uygulamalarında öğrenci alışkanlıklarını belirlemeyi (4 madde) hedeflemektedir. Yapılan betimleyici istatistiksel analiz sonucunda harmanlanmış öğrenmenin belirlenen maddeler boyutunda orta ve üzeri düzeyde avantajlarının olduğu ortaya çıkmıştır. Ayrıca öğrencilerin internet üzerinden yapılan çalışmalara günde ortalama 60 dakika ayırdığı görülmüştür.
Влияние применения внутренних механизмов корпоративного управления на стоимость компаний со стратегиями диверсификации и фокусирования
Authors: Назарова Варвара Вадимовна , Колыхалина Анжелика Владиславовна 
Published: December 2018

Проблематика корпоративного управления в России представляется актуальной на сегодня. Это обусловлено тем, что российские условия ведения бизнеса требуют особого подхода к формированию оптимальной системы корпоративного управления.
Цель исследования заключается в оценке влияния отдельных компонентов корпоративного управления на стоимость компаний с двумя стратегиями развития: диверсификации и фокусирования. Основная гипотеза исследования состоит в том, что в зависимости от выбранной стратегии развития (диверсификации или фокусирования) разные механизмы корпоративного управления оказывают различное влияние на стоимость данных компаний. Для обоснования выдвинутой гипотезы в работе построена регрессионная модель влияния основных факторов корпоративного управления на показатель экономической добавленной стоимости (EVA).
В результате проведенного исследования для компаний, использующих стратегии диверсификации и фокусирования, было выявлено влияние таких факторов корпоративного управления, как доля независимых директоров в составе совета, доля акций, принадлежащих менеджменту компании, и участие государства в акционерном капитале компании. По результатам построенной регрессионной модели для представленной выборки можно сделать следующие выводы: в зависимости от выбранной стратегии развития прослеживается различная структура корпоративного управления, в частности, для диверсифицированных компаний характерны более независимый совет директоров, а также большее участие государства в акционерном капитале компании. В условиях многообразия стратегий диверсификации в работе акцент сделан только на две стратегии. В перспективных исследованиях предполагается рассмотрения влияния прочих факторов корпоративного управления (например, корпоративного долга, формы выплаты дивидендов) на компании со стратегиями связанной и несвязанной диверсификации.
По сравнению с существующими исследованиями в представленной работе проведено комплексное исследование влияния таких факторов корпоративного управления, как доля независимых директоров в составе совета, доля акций, принадлежащих менеджменту компании, и участие государства в акционерном капитале компании на результаты российских компаний, реализующих стратегии диверсификации и фокусирования, сделаны практикоориентированные выводы.
Результаты исследования могут быть полезны менеджерам и руководителям корпоративных структур с целью оценки эффективности и результативности существующей в компании системы управления.
Public-Private Partnership as a Challenge for EAEU Cooperation
Authors: Safarov Shukhrat 
Published: December 2018

In this article the author analyzes perspectives on the Eurasian Single Economic Space’ concerning infrastructural investment projects. These perspectives are considered with a consideration of Public-Private Partnership (PPP) principles and the traditional framework of EAEU (Eurasian Economic Union) integration. The article examines national legal differences, such as the existence of regulations for PPPs, possible models for project realization and spheres where PPP could be used. The author also analyzes the characteristics of the most famous PPP projects in the EAEU.
The purpose of the article is to identify practical recommendations for the development of public-private partnerships to further cooperation between the EAEU countries.
This research stems from the study of international experiences of public-private partnerships, the adaptation thereof, and clarification of the necessary steps for the most efficient development of PPP in EAEU countries. As such, the following priority steps for EAEU countries are suggested:
1) EAEU countries should take steps to unite their respective legislative bases in terms of mutual compatibility so that public and private partners could act as inhabitants of the Union everywhere, removing not only customs barrier obstacles for them, but also additional tax restrictions;
2) EAEU countries should create an international council for problems and disputes pertaining to PPP which will include representatives of the countries of EAEU, representatives of the business and scientific communities and non-profit associations. Such a council was recommended to be set up at the United Nations during the third session of the United Nations Economic Commission for Europe on the problems of international public-private partnership, held in Geneva (Switzerland) on 18-19 April 2011;
3) EAEU countries should make use of practical experience in the implementation of interstate PPP projects. An example of a successful interstate PPP - the project for expansion and modernization of the international airport in Warsaw, through which more than 85% of all passengers of international flights have passed.
Competitive Coriolis Vibrating Gyroscope with a Metal Resonator
Authors: Raspopov V. Ya. , Ladonkin A. V. , Likhosherst V. V. 
Published: December 2018

The article deals with the design and features of manufacturing a Coriolis vibrating gyroscope (CVG, angular rate sensor) with a metal resonator. Piezoelectric elements are used to excite and detect oscillations of the resonator.The design of the resonator is very important, because the technical characteristics of the CVG mainly depend on the resonator. For the production of a high-quality metal resonator with predetermined properties, a good choice is the precision alloy of 21NKMT-VI. Elimination of defects in the manufacture of the resonator, which lead to a variety of frequencies and variability, is achieved by balancing. The basic method is balancing in the 4th form of the distribution of mass defects. Calibration of the CVG with the electronics unit is the final stage of the CVG manufacturing, which results in: providing a resonance tuning condition for the sensing element, determining the feedback coefficients of the oscillation retention loop, determining the metrological characteristics of the CVG, and obtaining the correction function of the output signal from various parameters after the test complex.When determining the correction function, the fact was taken into account that the signals for suppressing the quadrature and coriolis components are not absolutely independent. When the node signal is demodulated to quadrature and coriolis components, it is necessary to analyze the signal passed through piezoelectric elements, amplifiers and ADC. Each of these elements adds a temperature-dependent phase shift to the node signal. This phase shift can be taken into account, but not with absolute accuracy. Therefore, the output signal of the CVG should be considered as a linear combination of signals of the quadrature and coriolis components of the compensation signal. To reduce the noise of the output signal, it is possible to use various types of noise suppressing filtersThe results of tests of the CVG confirming its competitiveness in comparison with the commercial analogue. The electronic control module can be designed using the Russian element base.
Sertain Problematic Aspects of Fuzzy PID Regulation
Authors: Filimonov A. B. , Filimonov N. B. 
Published: December 2018

In recent years in view of the fact that the interest in the technologies of artificial intelligence in control systems by technical objects and technological processes are aroused, that fuzzy controllers find use more often. The given regulators carry out the process of the development of controlling actions on the basis of fuzzy logic, the application of which provides the design of control systems capable of functioning in conditions of incompleteness and fuzziness of knowledge about the dynamics of the control object. Fuzzy regulators have opened a new direction in the area of automatic control and according to many experts have a promising future. The given paper analyzes the dynamic characteristics and algorithmic singularities of fuzzy PID-regulation systems, compares the quality of clear and fuzzy regulation. The conducted analysis allows to state the absence of any real advantages of fuzzy regulators in comparison with classic clear regulators. Moreover, it is possible to distinguish a number of problematic aspects of fuzzy regulation methodology, important for practical automation:fuzzy control algorithms are much more complex than traditional clear regulation algorithms;the thesis about the advantages of fuzzy regulators seems to be reasonable, since each such regulator can be replaced by a more efficient and structurally less complex clear regulator;the thesis that on the basis of fuzzy approach it is possible to synthesize working systems of regulation without a priori knowledge and pre-project inspection of dynamic properties of objects of regulation is disputable.fuzzy approach is purely empirical and does not allow to solve the problems of stability, dynamic quality and robustness of the synthesized regulation systems at the theoretical level;fuzzy control algorithms are not applicable to complex dynamic objects. In particular, it concerns multi-connected objects of regulation and objects with delay;the methodology of fuzzy regulation does not allow to solve the important issues of optimization of regulation processes for engineering practice.
Comparison of methods for assessing the inflammatory response of the lower parts of the female reproductive tract
Authors: Budilovskaya Olga V. , Shipitsyna Elena V. , Pereverzeva Nadezhda A. , Vorobyova Nadezda E. , Spasibova Elena V. , Grigoryev Aleksey N. , Savicheva Alevtina M. 
Published: December 2018

Hypothesis/aims of study. A lack of timely diagnosis and treatment of inflammatory diseases of the lower genital tract in a woman can lead to serious reproductive disorders. The detection of inflammation is an important component of the diagnosis of these diseases. This study was undertaken to compare methods for detection of local inflammation in women with complaints of vaginal discharge.
Study design, materials, and methods. A total of 87 women having vaginal discharge were enrolled in the study. For the detection of inflammation, vaginal discharge was examined using microscopy and reverse transcriptase polymerase chain reaction (the ImmunoQuantex® test, DNA-Technology Ltd., Moscow, Russia).
Results. Vaginal infections caused by opportunistic microorganisms were detected in 27 women (31%), as follows: candidal vulvovaginitis (CVV) in 10 patients (11.5%), aerobic vaginitis (AV) in 14 patients (16.1%), and bacterial vaginosis (BV) in 14 patients (16.1%), with 8 (9.2%) of them having BV combined with CVV, AV or both infections. The results of the two methods fully agreed in the analysis of samples from women with CVV and AV as vaginal infections characterized by local inflammation. Testing samples from women with BV, which is a non-inflammatory syndrome, as well as women without vaginal infections resulted in significant discrepancies between the two methods. The sensitivity and specificity of the ImmunoQuantex® test compared to the microscopic method were 85.7% and 48.9%, respectively.
Conclusion. The new reverse transcriptase polymerase chain reaction based test for the evaluation of expression profiles of selected genes of immune response enables to assess the local immune status in the vagina. Determination of the presence or absence of inflammatory reaction in the vagina can be used as a diagnostic criterion for resolving discrepancies between laboratory data and clinical manifestations, as well as for choosing effective therapy.
Post partum headache: a case series
Authors: Bhatt Reema Kumar , Kumar Rohin , Singh L. B. 
Published: December 2018

Postpartum headache is the complaint of head, neck, or shoulder pain occurring during the first 6 weeks following delivery. Among the women who underwent neuraxial aneasthesia Post Dural puncture headache is one of the most common presentations. However, physicians should be aware that post Dural puncture headache is not the only cause of postpartum headache. Authors present a series of four cases that had varied presentation of post partum headache with varied diagnosis, the first case was of subdural haematoma where CT scan revealed an acute on chronic SDH. The second case was diagnosed as meningitis and the CSF for culture sensitivity grew Streptococcus Pneumoniae .In our third case of cortical vein thrombosis , NCCT followed by MR venogram revealed left transverse venous sinus thrombosis and our last case in the series was of posterior reversible encephalopathy syndrome where MRI confirmed the findings of typical findings are symmetric edema involving the white matter of the posterior regions of the cerebral hemispheres. The diagnostic dilemma was resolved by neuroimaging because the clinical presentation was not making us reach a satisfactory diagnosis of the cause of headache. Early resort to neuroimaging and multidisciplinary team effort paved way to early diagnosis and appropriate recovery of the patients.
Insilico Molecular Docking and Pharmacokinetic Studies of Selected Phytochemicals With Estrogen and Progesterone Receptors as Anticancer Agent for Breast Cancer
Authors: ISMAİL Sagir , UZAİRU Adamu , SAGAGİ Balarabe , SULEİMAN Muhd Sabiu 
Published: December 2018

Molecular docking and pharmacokinetic
studies were carried out on 20 selected phytochemicals with estrogen and
progesterone receptors and it was found that all the phytochemicals have strong
binding energy and high number of interactions, Gabridin has the highest
binding energy of -10.3kcal/mol and 12 numbers of various interactions when
docked with estrogen receptor, while Quercetin has the highest binding energy
of -9.6kcal/mol and about 14 numbers of various interactions when docked with
progesterone receptor. Pharmacokinetic study carried out showed that all the
leading compound (Gabridin and Quaercetin) are in agreement with lipinski′s
rule of 5 as they does not violate any of the rule, this shows that they will be readily
bioavailable. considering the high binding affinity of these compounds and
pharmacokinetic parameters, most of the phytochemicals used in this study can
be used in designing a highly pontent anti breast cancer drug.
MODIFICATION OF NOVEL ISOXAZOLINES OF FULVENE DERIVATIVES WITH 1,3-DIPOLAR CYCLOADDITION REACTION
Authors: Gunkara Omer 
Published: December 2018

In this work, 1,3-Dipolar cycloaddition
reactions were studied to synthesize fulvene derivatives containing isoxazoline groups in good yields. 1,3-Dipolar cycloaddition reactions are among the
most useful strategies for the preparation of organic compounds. All newly synthesized fulvene compounds were
structurally characterized by FTIR, 1H, 13C NMR and GC/MS
analyses.
The incidence and clinical features of meconium aspiration syndrome: a two-year neonatal intensive care experience
Authors: FEDAKAR Atiye 
Published: December 2018

Objectives: The aim of this present study was to review the clinical characteristics, risk factors, frequency of meconium aspiration syndrome (MAS), development and maternal demographic characteristics of the newborns born with meconium stained amniotic fluid (MSAF) in our neonatal intensive care unit. Methods: The files of the patients hospitalized in our neonatal intensive care unit between July 31, 2015 and July 31, 2017 and who were diagnosed with MAS or MBAS were examined retrospectively. Results: A total of 1410 patients were included during this period. Of these patients, 98 were term infants and 3 (34 weeks) were preterm infants. One hundred and one infants (7.1%) had MSAF and/or MAS. Of the patients, 63 were boys, 38 were girls. MAS developed in 61 patients (60.3%) who were hospitalized due to MBAS. No difference was detected between two groups in terms of the systemic diseases, age, pregnancy number, gestation week, delivery type, length of hospital stay of mother and birth weight of infant. The fifth minute Apgar score and need for resuscitation were found to be statistically significant in patients with MAS. We did not have any mortality. Conclusion: MAS frequency decreases in parallel with the developments in neonatal care but it is still a major cause of mortality and morbidity. We believe that chance of mortality and morbidity will decrease thanks to the close follow-up and early treatment in infants born with MSAF who are likely to develop MAS.
Blended Learning in the Study of Czech Students and Foreign Students
Authors: Hubackova Sarka 
Published: December 2018

The online courses are a very good motivation tool. They surely support all education, foreign language teaching inclusive. As for use of blended learning in foreign language teaching, it is a case of very progressive and useful way. Learning on our praxis and experience we regard blended learning as a very suitable means of teaching German and we count on its extension into other education fields. The researchers constantly enrich their created courses by using new technical possibilities. And also for this reason they are popular with our students. An anonymous evaluation of the courses takes place usually place in the end of a term. All students say that the teaching by means of supporting courses suits them. Keywords: Blended learning; Comparison; Foreign students; German language