bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic sleeve gastroplasty versus intragastric balloon insertion: efficacy, durability, and safety
Authors: Fayad Lea , Cheskin Lawrence J. , Adam Atif , Badurdeen Dilhana S. , Hill Christine , Agnihotri Abhishek , Dunlap Margo , Simsek Cem , Khashab Mouen A. , Kalloo Anthony N. , Kumbhari Vivek 
Published: March 2019

Abstract
Background Intragastric balloon (IGB) placement and endoscopic sleeve gastroplasty (ESG) are reported to be safe and effective endoscopic bariatric therapies. This study aimed to compare the patient demographics and therapeutic outcomes between the IGB and ESG procedures.
Methods: This was a retrospective review of prospectively collected data from consecutive patients between December 2015 and October 2017 who underwent IGB or ESG at a single academic center. Fluid-filled IGBs implanted for a 6-month duration were used. IGB and ESG patients were subjected to identical post-procedure dietary instructions and follow-up protocols. Body weight was recorded at 1, 3, 6, and 12 months post-procedure.
Results A total of 47 patients underwent IGB insertion and 58 underwent ESG. The IGB cohort had a lower baseline body mass index (BMI) than the ESG (34.5 vs. 41.5 kg/m2; P < 0.001) and a significantly lower proportion of men (2.1 % vs. 41.4 %; P < 0.001). IGB patients showed a mean (standard deviation [SD]) percentage total body weight loss (%TBWL) that was significantly lower than ESG patients at 1 month (6.6 % [2.6 %] vs. 9.9 % [2.4 %]; P < 0.001), 3 months (11.1 % [4.4 %] vs. 14.3 % [4.6 %]; P = 0.004), 6 months (15.0 % [7.6 %] vs. 19.5 % [5.7 %]; P = 0.01), and 12 months (13.9 % [9.0 %] vs. 21.3 % [6.6 %]; P = 0.005). The IGB cohort also experienced significantly more adverse events compared with the ESG (17 % vs. 5.2 %; P = 0.048).
Conclusions IGB placement and ESG result in clinically meaningful weight loss. However, ESG appears to provide clinically superior and more enduring weight loss with fewer adverse events compared with an IGB.
YaskoT 7OKM EL3aSKaR
Authors: Raish Michael 
Published: March 2019

AbstractThis paper presents an analysis of the linguistic contents of political protest signs that were erected at sit-in sites in Cairo and Alexandria, Egypt, during the summer of 2011. Sign authors employed a wide variety of linguistic codes and symbolic visual resources to subvert state authority, urge fellow citizens to action, and advocate a number of other political goals. Drawing on the methodology of Linguistic Landscape (LL) studies, the current effort investigates the relationship between linguistic code and factors such as sign location, medium, length, and thematic content. Multinomial logistic regression analysis reveals a significant relationship between sign code and medium, for example, as handwritten signs show more linguistic diversity than printed signs. Qualitative analysis focuses on sign authors, use of the symbolic and semiotic resources associated with these codes. This study of the ephemeral, transitory LL of Egyptian sit-in sites demonstrates the many and varied ways in which citizen sign authors manipulate concepts of formality, code choice, and imagery to encourage audiences to take up their messages as resources for social action in their own worlds.
Critical window variable selection: estimating the impact of air pollution on very preterm birth
Authors: Warren Joshua L , Kong Wenjing , Luben Thomas J , Chang Howard H 
Published: March 2019

Summary
Understanding the impact that environmental exposure during different stages of pregnancy has on the risk of adverse birth outcomes is vital for protection of the fetus and for the development of mechanistic explanations of exposure–disease relationships. As a result, statistical models to estimate critical windows of susceptibility have been developed for several different reproductive outcomes and pollutants. However, these current methods fail to adequately address the primary objective of this line of research; how to statistically identify a critical window of susceptibility. In this article, we introduce critical window variable selection (CWVS), a hierarchical Bayesian framework that directly addresses this question while simultaneously providing improved estimation of the risk parameters. Through simulation, we show that CWVS outperforms existing competing techniques in the setting of highly temporally correlated exposures in terms of (i) correctly identifying critical windows and (ii) accurately estimating risk parameters. We apply all competing methods to a case/control analysis of pregnant women in North Carolina, 2005–2008, with respect to the development of very preterm birth and exposure to ambient ozone and particulate matter $&lt;$ 2.5 $\mu$m in aerodynamic diameter, and identify/estimate the critical windows of susceptibility. The newly developed method is implemented in the R package CWVS.
Revisiting Reinhart and Rogoff after the crisis: a time series perspective
Authors: Amann Juergen , Middleditch Paul 
Published: March 2019

AbstractThis paper offers a straightforward and descriptive contribution to the recent and busy debate on fiscal discipline made popular by the seminal Reinhart and Rogoff (2010; Growth in a time of debt. American Economic Review, vol. 100, no. 2, 573–78) paper, after policymakers have sought foundation and justification for a policy known as austerity measures, following on from the sovereign debt crisis of 2010. We revisit the debate on whether or not higher debt levels impede growth rates and offer a time series perspective of a corrected data set and a more recent higher-frequency source. We find that with further hindsight, and from a time series perspective, there is little to no support for the view that higher levels of debt cause reductions in economic activity. In contrast to Reinhart and Rogoff (2010), we suggest that economic slumps tend to cause debt build-ups rather than vice versa.
Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction
Authors: Vinchi Francesca , Porto Graca , Simmelbauer Andreas , Altamura Sandro , Passos Sara T , Garbowski Maciej , Silva André M N , Spaich Sebastian , Seide Svenja E , Sparla Richard , Hentze Matthias W , Muckenthaler Martina U 
Published: March 2019

Abstract

Aims
Whether and how iron affects the progression of atherosclerosis remains highly debated. Here, we investigate susceptibility to atherosclerosis in a mouse model (ApoE−/− FPNwt/C326S), which develops the disease in the context of elevated non-transferrin bound serum iron (NTBI).

Methods and results
Compared with normo-ferremic ApoE−/− mice, atherosclerosis is profoundly aggravated in iron-loaded ApoE−/− FPNwt/C326S mice, suggesting a pro-atherogenic role for iron. Iron heavily deposits in the arterial media layer, which correlates with plaque formation, vascular oxidative stress and dysfunction. Atherosclerosis is exacerbated by iron-triggered lipid profile alterations, vascular permeabilization, sustained endothelial activation, elevated pro-atherogenic inflammatory mediators, and reduced nitric oxide availability. NTBI causes iron overload, induces reactive oxygen species production and apoptosis in cultured vascular cells, and stimulates massive MCP-1-mediated monocyte recruitment, well-established mechanisms contributing to atherosclerosis. NTBI-mediated toxicity is prevented by transferrin- or chelator-mediated iron scavenging. Consistently, a low-iron diet and iron chelation therapy strongly improved the course of the disease in ApoE−/− FPNwt/C326S mice. Our results are corroborated by analyses of serum samples of haemochromatosis patients, which show an inverse correlation between the degree of iron depletion and hallmarks of endothelial dysfunction and inflammation.

Conclusion
Our data demonstrate that NTBI-triggered iron overload aggravates atherosclerosis and unravel a causal link between NTBI and the progression of atherosclerotic lesions. Our findings support clinical applications of iron restriction in iron-loaded individuals to counteract iron-aggravated vascular dysfunction and atherosclerosis.
Biological diversity of carbon assimilation among isolates of the yeastDekkera bruxellensisfrom wine and fuel-ethanol industrial processes
Authors: da Silva Jackeline Maria , da Silva Gilberto Henrique Teles Gomes , Parente Denise Castro , Leite Fernanda Cristina Bezerra , Silva Carolina Santos , Valente Patrícia , Ganga Angélica Maria , Simões Diogo Ardaillon , de Morais Jr Marcos Antonio 
Published: March 2019

ABSTRACTDekkera bruxellensis is considered a spoilage yeast in winemaking, brewing and fuel-ethanol production. However, there is growing evidence in the literature of its biotechnological potential. In this work, we surveyed 29 D. bruxellensis isolates from three countries and two different industrial origins (winemaking and fuel-ethanol production) for the metabolization of industrially relevant sugars. The isolates were characterized by the determination of their maximum specific growth rates, and by testing their ability to grow in the presence of 2-deoxy-d-glucose and antimycin A. Great diversity was observed among the isolates, with fuel-ethanol isolates showing overall higher specific growth rates than wine isolates. Preferences for galactose (three wine isolates) and for cellobiose or lactose (some fuel-ethanol isolates) were observed. Fuel-ethanol isolates were less sensitive than wine isolates to glucose catabolite repression (GCR) induction by 2-deoxy-d-glucose. In strictly anaerobic conditions, isolates selected for having high aerobic growth rates were able to ferment glucose, sucrose and cellobiose at fairly high rates without supplementation of casamino acids or yeast extract in the culture medium. The phenotypic diversity found among wine and fuel-ethanol isolates suggests adaptation to these environments. A possible application of some of the GCR-insensitive, fast-growing isolates in industrial processes requiring co-assimilation of different sugars is considered.
Associated Form Morphism
Authors: Fedorchuk Maksym , Isaev Alexander 
Published: March 2019

AbstractWe study the geometry of the morphism that sends a smooth hypersurface of degree $d+1$ in ${\mathbb{P}}^{n-1}$ to its associated hypersurface of degree $n(d-1)$ in the dual space $\bigl ({\mathbb{P}}^{n-1}\bigr )^\vee $.
The SAMI Galaxy Survey: Bayesian inference for gas disc kinematics using a hierarchical Gaussian mixture model
Authors: Varidel Mathew R , Croom Scott M , Lewis Geraint F , Brewer Brendon J , Di Teodoro Enrico M , Bland-Hawthorn Joss , Bryant Julia J , Federrath Christoph , Foster Caroline , Glazebrook Karl , Goodwin Michael , Groves Brent , Hopkins Andrew M , Lawrence Jon S , López-Sánchez Ángel R , Medling Anne M , Owers Matt S , Richards Samuel N , Scalzo Richard , Scott Nicholas , Sweet Sarah M , Taranu Dan S , van de Sande Jesse 
Published: March 2019

Abstract
We present a novel Bayesian method, referred to as blobby3d, to infer gas kinematics that mitigates the effects of beam smearing for observations using integral field spectroscopy. The method is robust for regularly rotating galaxies despite substructure in the gas distribution. Modelling the gas substructure within the disc is achieved by using a hierarchical Gaussian mixture model. To account for beam smearing effects, we construct a modelled cube that is then convolved per wavelength slice by the seeing, before calculating the likelihood function. We show that our method can model complex gas substructure including clumps and spiral arms. We also show that kinematic asymmetries can be observed after beam smearing for regularly rotating galaxies with asymmetries only introduced in the spatial distribution of the gas. We present findings for our method applied to a sample of 20 star-forming galaxies from the SAMI Galaxy Survey. We estimate the global H α gas velocity dispersion for our sample to be in the range $\bar{\sigma }_v \sim$[7, 30] km s−1. The relative difference between our approach and estimates using the single Gaussian component fits per spaxel is $\Delta \bar{\sigma }_v / \bar{\sigma }_v = - 0.29 \pm 0.18$ for the H α flux-weighted mean velocity dispersion.
The Gaia ultracool dwarf sample – II. Structure at the end of the main sequence
Authors: Smart R L , Marocco F , Sarro L M , Barrado D , Beamín J C , Caballero J A , Jones H R A 
Published: March 2019

ABSTRACT
We identify and investigate known late M, L, and T dwarfs in the Gaia second data release. This sample is being used as a training set in the Gaia data processing chain of the ultracool dwarfs work package. We find 695 objects in the optical spectral range M8–T6 with accurate Gaia coordinates, proper motions, and parallaxes which we combine with published spectral types and photometry from large area optical and infrared sky surveys. We find that 100 objects are in 47 multiple systems, of which 27 systems are published and 20 are new. These will be useful benchmark systems and we discuss the requirements to produce a complete catalogue of multiple systems with an ultracool dwarf component. We examine the magnitudes in the Gaia passbands and find that the GBP magnitudes are unreliable and should not be used for these objects. We examine progressively redder colour–magnitude diagrams and see a notable increase in the main-sequence scatter and a bivariate main sequence for old and young objects. We provide an absolute magnitude – spectral subtype calibration for G and GRP passbands along with linear fits over the range M8–L8 for other passbands.
Urine Metabolites for Estimating Daily Intake of Nicotine From Cigarette Smoking
Authors: Benowitz Neal L , St. Helen Gideon , Nardone Natalie , Cox Lisa Sanderson , Jacob Peyton 
Published: March 2019

Abstract

Introduction
Accurate measurement of nicotine exposure from cigarette smoke is important in studying disease risk and level of dependence. Urine total nicotine equivalents, the molar sum of nicotine and six metabolites (NE7), accounts for more than 90% of a nicotine dose and is independent of individual metabolic differences. However, measuring NE7 is technically difficult and costly. We compared NE7, the gold standard of nicotine intake, with different combinations of fewer urinary nicotine metabolites. We also examined the impact of individual differences in nicotine metabolic rate, sex, and race on strength of association with NE7.

Methods
Urine samples from 796 daily smokers, who participated across five clinical studies, were assayed for nicotine and/or metabolites. Associations with NE7 were assessed by regression and Bland–Altman analyses.

Results
Overall, the molar sum of urine [cotinine + 3′-hydroxycotinine (3HC)] (NE2) and [nicotine + &#x2028;cotinine + 3HC] (NE3) were strongly correlated with NE7 (r = .97 and .99, respectively). However, in slow metabolizers NE2 was less predictive of NE7, whereas NE3 was equally robust. Urine total cotinine was also strongly correlated with NE7 (r = .87).

Conclusions
Urine NE3 is a robust biomarker of daily nicotine intake, independently of individual metabolic differences, whereas NE2 is less accurate in slow metabolizers. Our findings inform the selection of more rigorous and cost-effective measures to assess nicotine exposure in tobacco research studies.

Implications
The molar sum of urine total nicotine, cotinine and 3HC (NE3) is a robust biomarker of daily nicotine intake, independently of individual metabolic differences, and performs as well as measuring seven nicotine metabolites (NE7). The sum of cotinine and 3HC (NE2) is less accurate in slow metabolizers. Our findings inform the selection of more rigorous and cost-effective measures to assess nicotine exposure in tobacco research studies.
Adding value to real-world data: the role of biomarkers
Authors: Plant Darren , Barton Anne 
Published: March 2019

Abstract
Adding biomarker information to real world datasets (e.g. biomarker data collected into disease/drug registries) can enhance mechanistic understanding of intra-patient differences in disease trajectories and differences in important clinical outcomes. Biomarkers can detect pathologies present early in disease potentially paving the way for preventative intervention strategies, which may help patients to avoid disability, poor treatment outcome, disease sequelae and premature mortality. However, adding biomarker data to real world datasets comes with a number of important challenges including sample collection and storage, study design and data analysis and interpretation. In this narrative review we will consider the benefits and challenges of adding biomarker data to real world datasets and discuss how biomarker data have added to our understanding of complex diseases, focusing on rheumatoid arthritis.
Accuracy and Safety in Screw Placement in the High Cervical Spine
Authors: Hur Jung-Woo , Kim Jin-Sung , Ryu Kyeong-Sik , Shin Myeong-Hoon 
Published: March 2019

Study Design:
This study was a retrospective analysis.

Objective:
The purpose of present study was to evaluate accuracy, efficiency, and safety of intraoperative O-arm–based navigation system for the placement of C1 lateral mass screw (C1LMS) and C2 pedicle screws (C2PSs) in high cervical spine operations.

Summary of Background Data:
High screw misplacement rates, various pedicle morphometry and vertebral body size variations have led to a search of image-guided systems to improve the surgical accuracy of screw insertion in high cervical spine. The use of O-arm has been proposed for more accurate and efficient spinal instrumentation.

Materials and Methods:
Between June 2009 and August 2016, a total of 48 patients with atlantoaxial instability were surgically treated using the image-guidance system. To reconstruct atlantoaxial instability, we have been using Harm’s technique of C1LMS and C2PS fixations. A frameless, stereotactic O-arm–based image-guidance system was used for correct screw placement. Postoperative computed tomographic scan with multiplanar reconstructions were used to determine the accuracy of the screw placement.

Results:
A total of 182 screws, including 90 C1LMS and 92 C2PSs were inserted using image-guidance system. In total, 4.4% (4/90) of C1LMS and 7.6% (10/92) of C2PS had cortex violation over 2 mm and considered as “significant.” Among the significant cortex violations, “unexpected breech” was 3.3% of all the screws inserted. Two (2.1%) screws inserted had perforated the vertebral artery canal and iatrogenic vertebral artery stenosis was proved with postoperative computed tomography angiography. When divided into time periods, 60% of significant breech occurred during the beginning stage, 40% during adaptation stage and none during expert stage.

Conclusions:
In this study, the authors demonstrated that use of image-guidance system seems to be beneficial for high cervical instrumentation which requires much experience and steep learning curves. However, incidence of cortex violation does not disappear completely due to the close proximity to spinal canal and surrounding vessels.
Heritability of Corneal Curvature and Pentacam Topometric Indices: A Population-Based Study
Authors: Heydarian Samira , Hashemi Hassan , Yekta Abbasali , Ostadimoghaddam Hadi , Derakhshan Akbar , Aghamirsalim Mohammadreza , Khabazkhoob Mehdi 
Published: March 2019

Purpose:
To investigate familial aggregation of anterior and posterior corneal curvature, corneal astigmatism, and some corneal topometric indices using the Pentacam.

Methods:
Of 3,851 eligible individuals who resided in the selected areas, 2,779 met the conditions for analysis. However, analysis was limited to families whose Pentacam measures were available for at least 2 family members (father or mother and a child), resulting in 1,383 individuals in 382 families. All selected subjects underwent a set of examinations, including refraction, uncorrected and corrected visual acuity measurement, slitlamp biomicroscopy, and Pentacam imaging. Heritability estimation was used to calculate familial aggregation.

Results:
The results of our study showed a fairly high corneal curvature heritability. The heritability of K2 and K1 in the anterior surface was 58.61% (95% confidence interval [CI], 54.99–62.23) and 55.82% (95% CI, 52.66–58.98), respectively. The heritability of posterior corneal curvature was slightly higher than that of the anterior corneal curvature. The heritability of K2 and K1 in the posterior surface was 63.42% (95% CI, 60.07–66.77) and 59.67% (95% CI, 55.85–63.49), respectively. Investigation of the quantitative topographic corneal indices showed that index of surface variance (ISV), central keratoconus index, and index of vertical asymmetry (IVA) had the highest levels of heritability (81.2% [95% CI, 73.64–88.76], 75.21% [95% CI, 67.19–82.28], and 66.46% [95% CI, 61.99–70.93], respectively). However, keratometric power deviation and index of height asymmetry had the lowest heritability levels (7.48% 95% CI, [4.94–10.02] and 18.31% [95% CI, 16.07–20.55], respectively).

Conclusion:
The familial aggregation and relatively high heritability of the corneal curvature and some keratoconus-related indices, such as ISV and IVA, confirm a high correlation between these phenotypes and genetic factors and warrant further investigation of the genetic mechanisms in keratoconus.
Cultural Insensitivity Pervasive in Spanish Online Cosmetic Surgery Resources
Authors: Johnson Anna Rose , Bravo Miguel G. , Granoff Melisa D. , Lee Bernard T. 
Published: March 2019

Background
Hispanics are the second largest demographic that underwent cosmetic surgery in 2017. The popularity of cosmetic surgeries among this group has increased significantly within the past decade and is projected to continue rising. Patient-directed websites that provide educational materials addressing these procedures should include information that is accurate, comprehensible, and sensitive to the demographic's diverse cultural and ethnic needs. Online health resources have been shown to vary significantly in their quality and reliability. This can be inimical for patients, as misinformation has been associated with poor health outcomes. The aim of this study is to evaluate online Spanish patient-directed materials for the top 5 cosmetic surgeries performed in 2017 using validated metrics.

Methods
The top 5 cosmetic surgeries performed in 2017 according to the American Society of Plastic Surgeons were identified, and a Google search was performed using the following terms: “breast augmentation,” “liposuction,” “rhinoplasty,” “blepharoplasty,” and “abdominoplasty.” The top 10 websites providing relevant information in Spanish were identified for each procedure. Fifty unique web links were analyzed by 2 independent bilingual raters using the Cultural Sensitivity Assessment Tool, and mean reading grade level was determined. Interrater reliability was computed using a Cohen κ.

Results
Online information in Spanish was difficult to encounter, with an average of 130 websites evaluated to identify 10 websites for each surgery. The mean reading grade level of all evaluated pages was 10.19, appropriate for a high school sophomore. There were no statistically significant differences between cosmetic surgery procedures (P = 0.69). The mean cultural sensitivity score was 2.20 (2.08–2.38). No subgroup met the threshold score for acceptable cultural sensitivity of >2.5.

Conclusion
This study demonstrates that US websites do not offer appropriate-level Spanish materials for patients seeking information on cosmetic surgeries. Websites providing information in Spanish were often inaccurate automatic translations and further compromised reader understanding. In our search, we frequently encountered organizational statements expressing a commitment to diversity. Increased awareness and development of more culturally appropriate materials is paramount to effectively communicate with patients and begin to close the gap in cultural disparities in health literacy.