bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dehydrozingerone Exhibits Synergistic Antifungal Activities in Combination with Dodecanol against Budding Yeast via the Restriction of Multidrug Resistance
Authors: Yamawaki Chika , Yamaguchi Yoshihiro , Ogita Akira , Tanaka Toshio , Fujita Ken-ichi 
Published: October 2018

AbstractDrug resistance in fungal infections has been a more frequent occurrence with the increasing number of immunocompromised patients. In efforts to overcome the problem of fungal drug resistance, we focused on the phenolic compound dehydrozingerone, which is isolated from Zingiber officinale. The effectiveness of this compound on the model yeast Saccharomyces cerevisiae has not been reported. In our study, dehydrozingerone showed a weak antifungal activity against the yeast, but demonstrated a synergistic effect in combination with dodecanol, which typically only restricts cell growth transiently. Efflux of rhodamine 6G through the multidrug efflux pumps was significantly restricted by dehydrozingerone. The transcription level of PDR5, encoding a primary multidrug efflux pump in S. cerevisiae, was enhanced with dodecanol treatment, whereas the level was reduced by dehydrozingerone. These results suggest that dehydrozingerone may be effective for potentiating antifungal activity of other drugs that are expelled from fungi by multidrug transporters like Pdr5p.
Role of Moderate Hypothermia and Antegrade Cerebral Perfusion during Repair of Type A Aortic Dissection
Authors: McHugh Michael , Conway Brian , Nores Marcos , Stamou Sotiris 
Published: October 2018

The goal of this study was to compare early postoperative outcomes and actuarial survival between patients who underwent repair of acute type A aortic dissection with deep or moderate hypothermia.A total of 132 consecutive patients from a single academic medical center underwent repair of acute type A aortic dissection between January 2000 and June 2014. Of those, 105 patients were repaired under deep hypothermia (< 24 C°), while 27 patients were repaired under moderate hypothermia (≥24 C°). Median ages were 62 years (range: 27–86) and 59 years (range: 35–83) for patients repaired under deep hypothermia compared with patients repaired under moderate hypothermia, respectively (p = 0.451). Major morbidity, operative mortality, and 10-year actuarial survival were compared between groups.Operative mortality was 17.1 and 7.4% in the deep and moderate hypothermia groups, respectively (p = 0.208). Incidence of permanent stroke was 12.4% in the deep hypothermic circulatory arrest group and 0% in the moderate hypothermia group (p = 0.054). Actuarial 5- and 10-year survival demonstrated a trend for lower long-term mortality with moderate hypothermia compared with deep hypothermia (69% 5-year and 54% 10-year for deep hypothermia vs. 79% 5-year and 10-year for moderate hypothermia, log-rank p = 0.161).Moderate hypothermia is a safe and efficient alternative to deep hypothermia and may have protective benefits. Stroke rate was lower with moderate hypothermia.
Fibre Interplay in the Pregnant Uterus of the Frugivorous Bat Eidolon Helvum
Authors: Odukoya Samson , Odukoya Opeyemi , Adelodun Stephen 
Published: October 2018

Introduction There is currently a lack of adequate information on the mating, reproduction and the reproductive anatomy of the frugivorous bat Eidolon helvum. We, therefore, investigated their uterus during the non-pregnant and pregnant states for adequate information and comparison between the two states to ascertain what histological adaptations occur during pregnancy in relation to collagen and elastic fibers.
Materials and Methods A total of 47 female bats (E. helvum) were used, out of which 24 were pregnant and 23 were not. They were harvested on the Obafemi Awolowo University Campus. The animals were carefully screened, assumed to be presumably healthy and then sacrificed by cervical dislocation. The left and right uterine limbs with the uterine body and part of the placenta were fixed in 10% formal saline, processed for paraffin embedding and sectioned at 5 μm with a rotary microtome. The sections were stained using Verhoeff-van Gieson stain to demonstrate collagen and elastic fibers.
Results The results showed that both uterine limbs were histologically active during pregnancy. The prevalent fiber was the elastic type during the non-pregnant state, and collagen type during pregnancy.
Conclusion We conclude that elastic fibers tend to obey Hooke's law during pregnancy in the uterus of the frugivorous bat E. helvum, which signifies a form of histomorphological response or adaptation to pregnancy in the uterus of this bat species.
Fetal/Neonatal Pericardial Effusion in Down's Syndrome: Case Report and Review of Literature
Authors: Pharande Pramod , Balegar Virupakshappa Kiran , Mehta Bhavesh , Badawi Nadia 
Published: October 2018

AbstractWe report a preterm (35 4/7 weeks) male neonate with Down's syndrome (DS) diagnosed with isolated pericardial effusion (PE) at 20 weeks of gestation. He was born by precipitous delivery, needed no resuscitation and presented within first 24 hours of life with respiratory distress, anemia due to feto-maternal bleed, hypotension, hepatomegaly, and coagulopathy. Postnatal echocardiography confirmed a 5 mm rim of PE without tamponade, normal cardiac structure, and function. He was stabilized with ventilation, packed red cell, fresh frozen plasma, inotropes (dopamine, dobutamine, and adrenaline), and steroid (hydrocortisone). Subsequent evaluation confirmed hypothyroidism, transient myeloproliferative disorder (TMD), hepatic failure due to fibrosis/cirrhosis with portal hypertension, and steroid sensitive hypotension on two occasions possibly due to adrenal insufficiency. PE completely resolved over 2 weeks. In view of progressively worsening liver failure with ascites and portal hypertension, the family opted for palliation. Literature review has been discussed regarding perinatal onset of PE in DS.
Migration of Oxidized Cellulose to the Ventricle as a Complication of Endoscopic Third Ventriculostomy: A Case Report
Authors: da Silva Aldo , Fortes Thiago , Bomfim Rodrigo , Bomfim Filho Ângelo 
Published: October 2018

AbstractEndoscopic third ventriculostomy (ETV) is an increasingly common neurosurgical procedure. Hemostatic agentes (porcine gelatin and oxidized cellulose) are normally placed to plug the cortical hole after ETV to avoid cerebral spinal fluid leakage, subdural hygroma, and hemorrhage. Here we report the case of a 6-year-old boy with hydrocephalus who underwent ETV and which oxidized cellulose was placed to plug the cortical hole. Magnetic resonance imaging of the head performed 3 months after the procedure showed the presence of oxidized cellulose in the ventricle. After an unsuccessful attempt to remove the cellulose, it was decided that the patient should be kept under observation. Two years later, the child is in good health and without any complaints. Hemostatic agents (especially oxidized cellulose) used on the cortical hole after ETV can migrate to the ventricle and compromise the procedure. Follow-up should be performed for such patients, and the main focus should be on not causing further injury.
Epigenetik der Depression
Authors: Montag C. , Kiefer M. , Sanwald S. 
Published: October 2018

ZusammenfassungModerne ätiologische Theorien erklären die Entstehung der Major Depression durch eine Interaktion von Genen und Umwelt. Dabei stellt die individuelle Genetik einen Risikooder Resilienzfaktor dar, der im Zusammenspiel mit den individuellen Umweltbedingungen die Depressionsentwicklung begünstigen oder der Entstehung einer Depression vorbeugen kann. Solchen Theorien fehlte bislang das Bindeglied für das Zusammenspiel zwischen Genetik und Umwelteinflüssen. Ein solches Bindeglied ist die Epigenetik, die sich in den letzten Jahren als wegweisend in der Erforschung biologischer Marker stressbedingter Psychopathologie erwiesen hat. Der am besten erforschte epigenetische Mechanismus ist die DNA-Methylierung. Diese hat sich über viele Studien hinweg als ein möglicher Mechanismus etabliert, der dazu imstande ist, die psychopathogene Wirkung von Stress auf behaviorale, endokrine und molekulare Prozesse zu erklären. Diese Arbeit soll dazu dienen, die Grundlagen der Epigenetik und der DNA-Methylierung zu erläutern, um nachfolgend eine Übersicht über die Studienlage zu stress- und depressionsassoziierten Unterschieden in den Methylierungsmustern der bekanntesten Kandidatengene zu geben.
Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy
Authors: Wall Jonathan S. , Williams Angela D. , Foster James S. , Richey Tina , Stuckey Alan , Macy Sallie , Wooliver Craig , Campagna Shawn R. , Tague Eric D. , Farmer Abigail T. , Lands Ronald H. , Martin Emily B. , Heidel R. Eric , Kennel Stephen J. 
Published: October 2018

Significance
Amyloidosis is characterized by the deposition of pathologic protein fibrils in organs and tissues and is associated with ∼25 disorders, including Alzheimer’s disease and a systemic disease resulting from the aggregation of immunoglobulin light chains. Present treatments focus on reducing production of amyloid precursor proteins, but recent studies using amyloid-reactive antibodies have shown them capable of removing amyloid and improving organ function. To expand the utility of one such clinical antibody, designated 11-1F4, we have developed a synthetic, bifunctional peptide that binds many types of amyloid and mediates the recruitment of antibody to diverse amyloid types. This peptide approach may be used to enhance the efficacy and utility of existing antibodies, leading to broad-spectrum therapeutics and improved patient care.
Soft conductive micropillar electrode arrays for biologically relevant electrophysiological recording
Authors: Liu Yuxin , McGuire Allister F. , Lou Hsin-Ya , Li Thomas L. , Tok Jeffrey B.-H. , Cui Bianxiao , Bao Zhenan 
Published: October 2018

Significance
The large mechanical discrepancy at the cell–electrode interface (∼6 orders of magnitude difference in Young’s moduli) is known to significantly affect the cell’s behavior and its mechanotransduction pathways. To date, the Young’s moduli of the electrode materials do not match those of the cells, due to the limited availability of required electronic materials for microfabrication. Here, we present a soft micropillar electrode array made of electronically conductive hydrogel as a general tool for electrophysiological recording. The three-dimensional microelectrode provides biologically relevant mechanical microenvironment to the cells during electrophysiological recording with higher amplitude and signal-to-noise ratio compared with a state-of-the-art inorganic microelectrode.
BRI1 controls vascular cell fate in the
Arabidopsis
root through RLP44 and phytosulfokine signaling
Authors: Holzwart Eleonore , Huerta Apolonio Ignacio , Glöckner Nina , Garnelo Gómez Borja , Wanke Friederike , Augustin Sebastian , Askani Jana Christin , Schürholz Ann-Kathrin , Harter Klaus , Wolf Sebastian 
Published: October 2018

Significance
Cell-fate determination and cellular behavior in plants rely mainly on positional information and intercellular communication. A plethora of cues are perceived by surface receptors and integrated into an adequate cellular output. Here, we show that the small receptor-like protein RLP44 acts as an intermediary to connect the receptors for two well-known signaling molecules, brassinosteroid and phytosulfokine, to control cell fate in the root vasculature. Furthermore, we show that the brassinosteroid receptor has functions that are independent from the responses to its hormone ligands and reveal that phytosulfokine signaling promotes procambial cell identity. These results provide a mechanistic framework for the integration of multiple signaling pathways at the plasma membrane by shifting associations of receptors in multiprotein complexes.
Relative impacts of mild and major neurocognitive disorder on rate of verbal learning acquisition
Authors: Webber Troy A , Marceaux Janice C , Critchfield Edan A , Soble Jason R 
Published: October 2018

Abstract

Objective
The California Verbal Learning Test—second edition (CVLT-II) learning slope index may signal the presence of cognitive impairment, though the relative impacts of mild (MiND) and major (MaND) neurocognitive disorders on the rate of verbal learning acquisition remain unknown.

Methods
Latent intercept-only, linear, quadratic, and exponential models were fit to raw scores for the five CVLT-II learning trials of 197 veterans. Dummy-coded variables reflecting MiND and MaND predicted the growth factors.

Results
Quadratic growth best fit the data. MiND and MaND predicted reduced recall on each trial. MaND predicted reduced rate of learning acquisition (i.e., word gains per trial) over-and-above MiND, even after controlling for age, sex, education, race/ethnicity, and mono/bilingualism.

Conclusions
Nonlinear growth—with continuous but diminishing gains over trials—best characterized verbal learning acquisition. Reduced word recall each trial may help differentiate MiND from no neurocognitive disorder, while reduced rate of verbal learning acquisition may help differentiate MaND from MiND.
Gastrointestinal Microbiota Disruption and Risk of Colonization With Carbapenem-resistant Pseudomonas aeruginosa in Intensive Care Unit Patients
Authors: Pettigrew Melinda M , Gent Janneane F , Kong Yong , Halpin Alison Laufer , Pineles Lisa , Harris Anthony D , Johnson J Kristie 
Published: October 2018

Abstract

Background
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) colonizes the gastrointestinal tract of intensive care unit (ICU) patients, and CRPA colonization puts patients at increased risk of CRPA infection. Prior studies have not examined relationships between the microbiota, medications, and CRPA colonization acquisition.

Methods
Data and perirectal swabs were obtained from a cohort of ICU patients at the University of Maryland Medical Center. Patients (N = 109) were classified into 3 groups by CRPA colonization-acquisition status and antimicrobial exposure. We conducted 16S ribosomal RNA gene sequencing of an ICU admission swab and ≥1 additional swab and evaluated associations between patient characteristics, medications, the gastrointestinal microbiota, and CRPA colonization acquisition.

Results
ICU patients had low levels of diversity and high relative abundances of pathobionts. Piperacillin-tazobactam was prescribed more frequently to patients with CRPA colonization acquisition than those without. Piperacillin-tazobactam was associated with low abundance of potentially protective taxa (eg, Lactobacillus and Clostridiales) and increased risk of Enterococcus domination (odds ratio [OR], 5.50; 95% confidence interval [CI], 2.03–14.92). Opioids were associated with dysbiosis in patients who did not receive antibiotics; potentially protective Blautia and Lactobacillus were higher in patients who did not receive opioids. Several correlated taxa, identified at ICU admission, were associated with lower risk of CRPA colonization acquisition (OR, 0.58; 95% CI, .38–.87).

Conclusions
Antibiotics differed in their impact on the microbiota, with piperacillin-tazobactam being particularly damaging. Certain bacterial taxa (eg, Clostridiales) were negatively associated with CRPA colonization acquisition. These taxa may be markers of risk for CRPA colonization acquisition and/or serve a protective role.
Evaluation of Legendre polynomials by a three-term recurrence in floating-point arithmetic
Authors: Hrycak Tomasz , Schmutzhard Sebastian 
Published: October 2018

Abstract
We prove new error estimates for a three-term recurrence that is used to compute Legendre polynomials. To this end we derive a bilinear representation of the cross-product of Legendre functions and demonstrate estimates of the cross-product that are needed in the error analysis of the recurrence.
Recovery operators, paraconsistency and duality
Authors: Carnielli Walter , Coniglio Marcelo E , Rodrigues Abilio 
Published: October 2018

Abstract
There are two foundational, but not fully developed, ideas in paraconsistency, namely, the duality between paraconsistent and intuitionistic paradigms, and the introduction of logical operators that express metalogical notions in the object language. The aim of this paper is to show how these two ideas can be adequately accomplished by the logics of formal inconsistency (LFIs) and by the logics of formal undeterminedness (LFUs). LFIs recover the validity of the principle of explosion in a paraconsistent scenario, while LFUs recover the validity of the principle of excluded middle in a paracomplete scenario. We introduce definitions of duality between inference rules and connectives that allow comparing rules and connectives that belong to different logics. Two formal systems are studied, the logics mbC and mbD, that display the duality between paraconsistency and paracompleteness as a duality between inference rules added to a common core—in the case studied here, this common core is classical positive propositional logic. The logics mbC and mbD are equipped with recovery operators that restore classical logic for, respectively, consistent and determined propositions. These two logics are then combined obtaining a pair of LFI and undeterminedness, namely, mbCD and mbCDE. The logic mbCDE exhibits some nice duality properties. Besides, it is simultaneously paraconsistent and paracomplete, and able to recover the principles of excluded middle and explosion one at a time. The last sections offer an algebraic account for such logics by adapting the swap structures semantics framework of the LFIs the LFUs. This semantics highlights some subtle aspects of these logics, and allows us to prove decidability by means of finite nondeterministic matrices.
Music and cremation rituals in The Netherlands: A fine-grained analysis of a crematorium’s playlist
Authors: van der Smissen Doris , Steenbakker Margaret A , Hoondert Martin J M , van Zaanen Menno M 
Published: October 2018

Abstract
Although music is an important part of cremation rituals, there is hardly any research regarding music and cremations. This lack of research has inspired the authors to conduct a long-term research project, focusing on musical and linguistic aspects of music played during cremations. This article presents the analysis of a playlist consisting of twenty-five sets of music, each consisting of three tracks, used in a crematorium in the south of The Netherlands from 1986 onward. The main objective is to identify the differences and similarities of the twenty-five sets of musical tracks regarding content and musical properties. Consequently, we aim to provide insight in the history of (music played during) cremation rituals in The Netherlands. To analyze the musical properties of the sets, the authors use both a qualitative approach (close reading and musical analysis) and a computational analysis approach. The article demonstrates that a combination of a close reading and musical analysis and a computational analysis is necessary to explain the differences in properties of the sets. The presented multi-method approach may allow for comparisons against musical preferences in the context of current cremations, which makes it possible to trace the development of music and cremation rituals.
The Prognostic Significance of a Cast Fourth Ventricle in Ruptured Aneurysm Patients With Intraventricular Hemorrhage in the Barrow Ruptured Aneurysm Trial (BRAT)
Authors: Catapano Joshua S , Zabramski Joseph M , Baranoski Jacob F , Brigeman Scott , Morgan Clinton D , Hendricks Benjamin K , Mooney Michael A , Albuquerque Felipe C , Nakaji Peter , Spetzler Robert F 
Published: October 2018

Abstract

BACKGROUND
Ruptured aneurysms causing intraventricular hemorrhage (IVH) are associated with high morbidity. The presence of blood that completely fills the fourth ventricle (cast fourth ventricle, CFV) is thought to be particularly ominous, but studies documenting the outcome of such cases are lacking.

OBJECTIVE
To investigate the outcomes of patients with aneurysmal subarachnoid hemorrhage (aSAH) and CFV.

METHODS
We reviewed 406 patients enrolled in the Barrow Ruptured Aneurysm Trial (BRAT, NCT01593267, clinicaltrials.gov); 238 patients with aSAH and IVH were identified, and imaging was reviewed for the presence of CFV. Outcome was evaluated at the 1-yr follow-up. A poor outcome was defined as modified Rankin Scale score >2.

RESULTS
CFV was identified in 25 patients. Admission Glasgow Coma Score was lower in CFV patients, 7.8 versus 11.5 (P < .001). At discharge and the 1-yr follow-up, patients with CFV had a greater risk of a poor outcome (P < .001 and P = .002, respectively). In a subgroup analysis of 79 patients with IVH and initial Glasgow Coma Score ≤ 8, almost 50% of the patients with IVH but without CFV had made a good recovery versus 7% of patients with CFV (odds ratio [OR] 15, P = .002). On multivariate analysis, CFV was a greater predictor of a poor prognosis at 1 yr post-aSAH than Hunt and Hess grade >3 (6.4 OR vs 2.9 OR [P < .001], respectively).

CONCLUSION
The presence of CFV is a predictor of poor outcome in patients with aSAH. When compared to other patients with IVH and aSAH, CFV is a stronger predictor of a poor outcome than a poor Hunt and Hess Grade.
TYPE TESTING OF LiF:Mg,Cu,P (TLD-100H) WHOLE-BODY DOSEMETERS FOR THE ASSESSMENT OF Hp(10) AND Hp(0.07)
Authors: Pereira J S , Pereira M F , Rangel S , Caldeira M , Carvalhal G , Santos L M , Cardoso J V , Alves J G 
Published: October 2018

Abstract
In this work, the initial results of the type testing of the LiF:Mg,Cu,P (TLD-100H) whole-body personal dosemeters are presented. An assessment of reproducibility, linearity of the response, the residual signal as a function of the dose, energy and angular dependence of the response was performed. In general, the dosemeters show good reproducibility for different dose values and a linear behaviour for a range between 0.1 and 300 mSv. The detection limits obtained are lower than 50 μSv. The system presents a good energy and angular response for different radiation qualities.