bluuebunny/crossref_metadata_2025_split huggingface dataset:
De una sospecha de neoplasia al diagnóstico de una enfermedad por almacenamiento lisosomal: enfermedad de Gaucher, un reporte de caso
Authors: Hurtado Ascanio Laura Camila , Perez Henao Paula , Quintero Vega Guillermo Enrique 
Published: December 2024

Gaucher disease is the most common Lysosomal Storage Disease, it is caused by the defective function of the Glucosylceramidase enzyme that generates the accumulation of its substrate, glucosylceramide. Given that the signs and symptoms are very variable and depend on the organ affected by glucosylceramide deposition, it is relevant to know the key aspects of this pathology to be able to give an accurate diagnosis and thus timely treatment. Clinical case: A 50-year-old female patient presents with a history of hepatosplenomegaly, thrombocytopenia, and bone pain. At first, a neoplasia was suspected, and a positon emission tomography was performed with foci of hypermetabolism and cytolytics in the axial and appendicular bone marrow, a bone marrow biopsy shows 90% involvement by histiocytes and evidence of decreased activity of Glucosylceramidase. Conclusions: Suspicion should be raisd and screening for Gaucher Disease must be done, in case of signs and symptoms such as splenomegaly, thrombocytopenia and/or bone pain. Taking in to account this is a rare disease, the only way of making a diagnosis is thinking about it, and thus initiate the appropriate treatment that helps improve the quality of life of patients.
Prediction of cardiotoxicity in breast cancer patients exposed to anthracyclines during trastuzumab treatment.
Authors: Medina Pabón Miguel Ángel , Tatis Mendez Jose Fidel , Gómez Wolff Luis Rodolfo , Lopera Arrázola Nicolás , Llamas Jiménez Alexis del Carmen , Jaramillo Gómez Nicolás Ignacio 
Published: December 2024

Trastuzumab (TRZ) improves survival in women with HER-2-positive breast cancer but is associated with significant cardiotoxicity, especially when administered after anthracyclines (AC) and cyclophosphamide. Methods: We conducted an ambispective cohort study from an oncology center to evaluate the cardiac safety of trastuzumab combined with anthracyclines in women with stage I-III HER-2-positive breast cancer who received a regimen based on AC (doxorubicin and cyclophosphamide) followed by trastuzumab between January 2017 and December 2022. Cardiovascular risk factors such as left ventricular ejection fraction (LVEF), global longitudinal strain (GLS), and treatment discontinuation were collected. Cardiac events (CE) were defined according to the new European Society of Cardiology (ESC) 2022 criteria (including reduction in LVEF and GLS). In addition, Cox regression was used to predict associations with cardiotoxic development. Results: Of 205 women, median were 52 years old (IQR 42-59). Eighty-four presented with TRZ-induced cardiotoxicity, with a median treatment duration of 9 months (IQR 8-11) (LVEF reduction ≥ 10%) and 7 months (IQR 6-8) (GLS reduction ≥ 15%), respectively. Age older than 65 years (HR:1.67; 95% CI 0.98-2.8; P=0.05), history of coronary artery disease (HR:4.67; 95% CI 1.4-14; P=0.012), and adjuvant radiotherapy to the left breast (HR:1.34; 95% CI 0.8-2.2 P=0.242) were associated with the development of early cardiotoxicity. Conclusions: The incidence of cardiotoxicity in breast cancer patients treated with AC associated with TRZ is high given the new ESC criteria with the performance of GLS as a diagnostic test. These findings suggest more intensive cardiac monitoring in patients with risk factors over 65 years of age with previous coronary artery disease, and exposed to radiotherapy in the left breast.
O IMPACTO DA IMUNIDADE OBJETIVA DO PAPEL DESTINADO À IMPRESSÃO DE LIVROS, JORNAIS E PERIÓDICOS APRESENTADA NO ART. 150, INCISO IV, ALÍNEA DA CONSTITUIÇÃO FEDERAL DE 1988
Authors: Silva Caio Vinicius Costa , Fraga Emilly Raquel de Souza , Sobrinho Osvaldo Esteves 
Published: December 2024

O presente artigo tem como principal objetivo compreender a isenção de impostos sobre o papel destinado à impressão de livros, jornais e periódicos, com o intuito de elucidar se é possível mensurar o impacto na arrecadação da União. A Constituição Federal Brasileira, de 1988, veda a tributação a livros, jornais, periódicos e papéis destinados a sua impressão - impedindo a arrecadação por meio dos objetos mencionados. A norma - considerada uma Imunidade - é originária de textos constitucionais anteriores, possui interpretação do judiciário para sua existência, e gera impacto econômico pela não-arrecadação tributária intencional. Portanto, por meio deste artigo, visa-se entender os motivos e objetivos dessa isenção, quais são os requisitos para pessoas jurídicas que desejem beneficiar-se dela e a compreensão de seu impacto econômico.
Gas exchange velocities (k600), gas exchange rates (K600), and hydraulic geometries for streams and rivers derived from the NEON Reaeration field and lab collection data product (DP1.20190.001)
Authors: Aho Kelly S. , Cawley Kaelin M. , Hensley Robert T. , Hall Jr. Robert O. , Dodds Walter K. , Goodman Keli J. 
Published: December 2024

Abstract. Air–water gas exchange is essential to understanding and quantifying many biogeochemical processes in streams and rivers, including greenhouse gas emissions and metabolism. Gas exchange depends on two factors, which are often quantified separately: (1) the air–water concentration gradient of the gas and (2) the gas exchange velocity. There are fewer measurements of gas exchange velocity compared to concentrations in streams and rivers, which limits accurate characterization of air–water gas exchange (i.e., flux rates). The National Ecological Observatory Network (NEON) conducts SF6 gas-loss experiments in 22 of their 24 wadeable streams using standardized methods across all experiments and sites, and publishes raw concentration data from these experiments on the NEON data portal. NEON also conducts NaCl injections that can be used to characterize hydraulic geometry at all 24 wadeable streams. These NaCl injections are conducted both as part of the gas-loss experiments and separately. Here, we use these data to estimate gas exchange and water velocity using the reaRate R package. The dataset presented includes estimates of hydraulic parameters, cleaned raw concentration SF6 tracer-gas data (including removing outliers and failed experiments), estimated SF6 gas-loss rates, normalized gas exchange velocities (k600; m d−1) and normalized depth-dependent gas exchange rates (K600; d−1). This dataset provides one of the largest compilations of gas-loss experiments (n=339) in streams to date. This dataset is unique in that it contains gas exchange estimates from repeated experiments in geographically diverse streams across a range of discharges. In addition, this dataset contains information on the hydraulic geometry of all 24 NEON wadeable streams, which will support future research using NEON aquatic data. This dataset is a valuable resource that can be used to explore both within- and across-reach variability in the hydraulic geometry and gas exchange velocity in streams. The data are available at https://doi.org/10.6073/pasta/18dcc1871ee71cf0b69f2ee4082839d0 (Aho et al., 2024), and the reaRate R package code is available at https://doi.org/10.5281/zenodo.12786089 (Cawley et al., 2024).
Tangible and intangible ex post assessment of flood-induced damage to cultural heritage
Authors: De Lucia Claudia , Amaddii Michele , Arrighi Chiara 
Published: December 2024

Abstract. Floods pose significant risks to cultural heritage (CH), yet post-disaster damage data on CH remain lacking. In this paper, we address this gap by focusing on the ex post assessment of flood-induced damage to CH. The method involves the identification of damaged assets and a field survey to assess loss in tangible value (LTV) and loss in intangible value (LIV). The potential contributing factors, e.g. water depth and river slope, are analysed through geospatial analysis. Ex post damage data on CH are compared with the outcome of an ex ante analysis based on available methods to verify the quality of exposure data and possible limitations. The method is applied to the 15–16 September 2022 flood event that occurred in the Marche region (Italy). The survey involved 14 CH in 4 municipalities and 3 catchments. Results highlight the inadequacy of existing exposure data for ex ante damage assessment and the importance of building characteristics. However, ex post data confirm that religious architectures are likely to suffer the highest LTV and LIV. The ex post damage analysis provided a semi-quantitative evaluation of both LTV and LIV in relation to flood characteristics. Notably, significant correlations between LTV and flood depth, as well as with the slope of the riverbed (a proxy for river flow velocity), were found. LIV correlates well to flood depth and river slope albeit with lower R2 and larger RMSE, highlighting that intangible impact analysis requires more effort than hazard characterization. Further research should increase the availability of ex post damage data on CH to form the basis for damage model validation and development of empirical vulnerability functions.
Personajes y avatares femeninos en los videojuegos subyacentes a la narrativa fílmica: evolución, roles y transgresiones.
Authors: Jiménez Sánchez Álvaro , Lavín José M. , Martín García Noemí 
Published: December 2024

Los avatares han sido utilizados en multitud de contextos, especialmente, en el ámbito de los videojuegos. Por su parte, el cine lleva décadas usando estos entornos virtuales gamificados como parte inherente a la trama fílmica para que sus personajes se desarrollen y representen realidades habidas y por haber. El objetivo de esta investigación es centrarse en aquellos personajes y avatares femeninos de aquellos filmes cuya trama viene marcada por el uso de un videojuego, analizar su evolución, roles y posibles transgresiones. Metodología. Se realizó un análisis fílmico discursivo de 20 producciones audiovisuales y decenas de pesonajes y avatares femeninos. Resultados. Se observa una clara evolución de estas, donde en los últimos años el séptimo arte lleva planteando originales implicaciones entre la relación personaje y avatar femenino. Los roles principales encontrados son que ellas suelen ejercer de: objeto de deseo, guerreras, jugadoras de videojuegos y, en menor grado, de informáticas. Se demuestra que el videojuego sirve de espacio alternativo para que los personajes femeninos, mediante sus avatares, puedan liberarse y expresarse de forma diferente a la realidad. Además, algunas películas las utilizan para reflexionar sobre temas como la aceptación de la imagen corporal, la identidad de género y sexual, y la orientación sexual. Conclusiones y aportes. El aporte y originalidad de este trabajo radica en que, si bien se ha tratado mucho el tema de los avatares femeninos en sus múltiples contextos, poco se ha analizado en el panorama cinematográfico y, menos aún, de forma tan holística dentro de los videojuegos que el cine ha incluido. Se concluye que este tipo de películas son un buen retrato de la evolución e implicaciones que los personajes y avatares femeninos han desempeñado en los videojuegos utilizados como motores de la trama fílmica.
Intergenerational cycles of violence: Risk factors of child abuse victims who turned violent offenders growing up
Authors: Uktubara Ade Lily Reakid Arin , Ichwan Hendariyanto Vendy , Riskika Haressa Lintang , Chusairi Achmad 
Published: December 2024

Child abuse has profound consequences for survivors. It increases the the risk of brain disorder, emotional regulation, self-adjustment, learning, and memory disorders, and is correlated with anti-social interactions and violent behavior in adulthood. This research aims to understand how individuals who have experienced child maltreatment, committed a violent crime once they became an adult. A narrative method was used in this study. By illuminating how early-life victimization could shape the life of an individual, we hope to shed light and eventually prevent survivors of child maltreatment down a path of violence. Three violent offenders were the subjects of this study. Data collection methods in the form of semi-structured interviews and non-human sources of information were carried out on three perpetrators of criminal acts of murder and abuse which resulted in death. The results in this study were analyzed using thematic analysis in chronological order. It was revealed that there are several risk factors in the series of cases of criminal acts. Intergenerational transmission of multiple risk factors and the use of illegal drugs are the main causes of aggressive behavior and criminal acts.
IMPLEMENTASI PEMBINAAN KEMANDIRIAN SENI LUKIS KERUDUNG DI LAPAS PEREMPUAN KELAS IIA TANGERANG
Authors: Rachmayanthy Rachmayanthy , Deviana Arum Shinta , Monitaria Nita 
Published: December 2024

Impementasi Pembinaan Keterampilan bagi narapidana perempuan di Lembaga Pemasyarakatan dirasa sangat penting karena perempuan juga memiliki hak atas kelangsungan hidupnnya. Dengan implementasi pembinaan kemandirian ini bertujuan agar narapidana perempuan dapat melangsungkan kehidupannya setelah bebas dengan menggunakan keahlian yang diberikan saat berada didalam Lembaga Pemasyarakatan, salah satunya yaitu melalui pembinaan kemandirian kerudung Lukis. Melukis adalah seni ditafsirkan untuk orang- orang yang menghargai keindahan. Lukisan mewakili ide dan perasaan dengan kreasi. Beberapa sifat estetika dalam gambar visual dua dimensi. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana proses pembuatan kerudung Lukis yang ada di Lembaga Pemasyarakatan Kelas IIA Tangerang. Metodologi diterapkan desain ini memiliki metode campuran, yaitu kombinasi metode kualitatif dengan tindakan Observasi. Dapat disimpulkan bahwa implementasi program kemandirian kerudung Lukis di Lapas Perempuan Kelas IIA Tangerang berjalan dengan baik dan efektif. Sebagai bekal bagi Warga Binaan Pemasyarakan setelah menyelesaikan masa pidananya dan Kembali ke dalam masyarakat.
Implementasi Pemenuhan Hak Narapidana Penyandang Disabilitas di Lembaga Pemasyarakatan Indonesia: Analisis dan Hambatan
Authors: Andriyan Ferry , Wibowo Padmono 
Published: December 2024

Penelitian ini menginvestigasi implementasi pemenuhan hak narapidana penyandang disabilitas di Lembaga Pemasyarakatan Indonesia serta faktor-faktor penghambat yang memengaruhi pemenuhan hak-hak mereka. Dengan metode penelitian deskriptif kualitatif dan pendekatan hukum normatif, penelitian ini menggunakan sumber-sumber pustaka dan data sekunder untuk menganalisis status saat ini. Hasil penelitian menunjukkan bahwa narapidana penyandang disabilitas memiliki hak yang sama dengan narapidana lainnya, namun mereka memerlukan perlakuan khusus untuk memastikan aksesibilitas, pembinaan, dan layanan kesehatan yang sesuai dengan kebutuhan mereka. Terdapat beberapa hambatan dalam pemenuhan hak-hak ini, termasuk kurangnya aksesibilitas di dalam Lapas, kurangnya fasilitas khusus, dan kesadaran yang terbatas tentang hak-hak narapidana penyandang disabilitas.Penelitian ini menyimpulkan bahwa perbaikan dalam pemenuhan hak narapidana penyandang disabilitas memerlukan upaya yang lebih besar, termasuk perbaikan sarana dan prasarana aksesibilitas di dalam Lapas, pelatihan petugas Lapas tentang hak-hak narapidana penyandang disabilitas, serta peningkatan kesadaran tentang isu ini di masyarakat. Penelitian ini memberikan wawasan yang lebih dalam tentang masalah ini dan memberikan dasar untuk langkah-langkah lebih lanjut dalam meningkatkan pemenuhan hak narapidana penyandang disabilitas di Indonesia.

Kata kunci: Narapidana, Disabilitas, Pelayanan, Lembaga Pemasyarakatan
H5N1 Avian Influenza: Global Circulation and Response Strategies
Authors: Wei Dongmei , Wu Xiaoya , Chen Heming , Chen Kaiyun , Xia Ningshao , Chen Junyu , Chen Yixin 
Published: December 2024

Review
H5N1 Avian Influenza: Global Circulation and Response Strategies

Dongmei Wei 1, Xiaoya Wu 1, Heming Chen 1, Kaiyun Chen 1, Ningshao Xia 1,2, Junyu Chen 1,2,* and Yixin Chen 1,2,*

1 State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, School of Life Sciences, Xiamen University, Xiamen 361102, China
2 National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Collaborative Innovation Center of Biologic Products, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University, Xiamen 361102, China
* Correspondence: 1006337050@qq.com (J.C.), yxchen2008@xmu.edu.cn (Y.C.)

Received: 9 September 2024; Revised: 29 September 2024; Accepted: 15 October 2024; Published: 25 October 2024

Abstract: The highly pathogenic avian influenza virus H5N1 has garnered global attention due to its high pathogenicity and mortality rates. In recent years, the outbreak of the H5N1 subtype 2.3.4.4b in various mammals has raised concerns about its pandemic potential. This paper reviews the global prevalence and impact of H5N1 virus, explores the current status and challenges in the existing technological platforms for H5N1 vaccine and diagnostic development, and further evaluates the effectiveness and application prospects of current H5N1 therapeutics. This article aims to provide a robust reference to guide the global preparedness for future pandemic potential of avian influenza H5N1.
The Multifaced Roles of Hepatic Macrophages in MASLD
Authors: Sui Xiaoping , Wu Minqi , Yang Xue , Wang Yanan 
Published: December 2024

Review
The Multifaced Roles of Hepatic Macrophages in MASLD

Xiaoping Sui 1, Minqi Wu 1, Xue Yang 1 and Yanan Wang 1,2,*

1 Med-X Institute, Center for Immunological and Metabolic Diseases, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an Jiaotong University, Xi’an, 710061, China
2 Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an Jiaotong University, Xi’an, 710061, China
* Correspondence: yanan.wang@xjtu.edu.cn; Tel.: +86-29-8532-3338

Received: 20 September 2024; Revised: 14 October 2024; Accepted: 24 October 2024; Published: 29 October 2024

Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming the leading cause of chronic liver disease-related morbidity and mortality globally. It encompasses a spectrum from metabolic dysfunction-associated steatotic liver (MASL) to metabolic dysfunction-associated steatohepatitis (MASH), potentially advancing to cirrhosis and hepatocellular carcinoma. While the pathogenesis of MASLD is complicated and not yet completely elucidated, hepatic macrophages, including liver resident Kupffer cells (Res-KCs) and recruited circulating monocyte-derived macrophages (MoDMs), play a pivotal role in its initiation and progression. Recent advancements in single-cell RNA sequencing have unveiled significant heterogeneity among macrophages and their diverse contributions to MASLD progression. This review delineates the origin and surface markers of hepatic macrophages, emphasizing their multifaceted roles in the pathogenesis of MASLD in steatosis, inflammation and fibrosis. Furthermore, we delve into the latest advancements in pharmacological treatment strategies for patients with MASLD.
Looking through Three ‘I’s
Authors: Young Clive , Asensio Maria 
Published: December 2024

Although the pedagogic use of film and video has a long history, its widespread use has always been limited by production costs and delivery difficulties. In recent years costs of production have fallen and the web has emerged as a mainstream educational distribution medium. Video itself can be used in many ways: 'talking head', interviews, video diaries, video labs, simulations, instructional sequences, 'fly on the wall', video help etc. Through the browser, 'streaming' video sequences can be linked to slides, text conferencing, whiteboards, video conferencing, shared applications, online assessment and third party web sites. A major element of the JISC/DNER Click and Go Video project is to move beyond the current understanding of video as a purely presentational tool. The seamless combination of digital video with other tools offers an opportunity to experiment with video as a focus for networked learning. However there is an acute lack of pedagogic resources, research and evaluation on the use of video streaming for teaching and learning. The pedagogical challenge faced by teaching staff and practitioners is not only to choose the appropriate streaming technology but also to design meaningful learning events. In this paper we introduce a way to analyse video use through what we have named the Three 'I's Framework - image, interactivity and integration. This conceptual framework seeks to provide a practical decision tool to help teaching staff and practitioners with the pedagogic design and development of video streaming resources for online learning. Our aim is to provide a way of understanding the role of video as it changes from a presentation tool to a focus for networked learning.
Lower Total Shoulder Arthroplasty Cost of Care at an Ambulatory Surgical Center Versus a Main Hospital
Authors: Guareschi Alexander S. , Hoch Caroline P. , Deacon James M. , Eichinger Josef K. , Friedman Richard J. , Gross Christopher E. , Scott Daniel J. 
Published: December 2024

Introduction:
Total shoulder arthroplasty (TSA) is an increasingly common orthopaedic procedure. Expansion of TSA to outpatient surgical settings has the potential to reduce costs, although there is limited research on the cost and efficiency of this shift in surgical site of care. The purpose of this study is to compare costs and efficiency of TSA between an ambulatory surgical center (ASC) and a hospital.

Methods:
Retrospective cost and time data were obtained from 175 surgeries performed from 2019 to 2020 using a single institution's existing cost accounting system (hospital = 97, ASC = 78). In addition, 34 patients were prospectively enrolled undergoing primary anatomic (n = 10) or reverse (n = 24) TSA. Hand-timed data were collected at each location (ASC = 23, hospital = 11) throughout the entire episode of perioperative care. Data were analyzed to investigate the effects of surgery location on labor cost, efficiency, and provider time.

Results:
The cost per TSA in the ASC was markedly lower than that in the hospital (ASC = $27,250.59, hospital = $30,266.80; P < 0.001). Examining individual discrete activities, TSA performed at the ASC was markedly longer in multiple preoperative, intraoperative, and postanesthesia care unit categories, with the greatest difference being case duration (ASC = 2.2 hours, hospital = 1.7 hours; P = 0.002). The decreased cost in the ASC, despite longer case duration, can be explained by differences in cost margins between locations with ASC cases having markedly lower costs for almost all categories.

Conclusion:
It is markedly more expensive for patients to undergo TSA in a hospital setting than in an ASC. Furthermore, preoperative and postanesthesia care unit times markedly contribute to differences in efficiency associated with different surgical platforms, representing target areas to focus on improving efficiency of care delivery. These findings should be considered by orthopaedic surgeons when considering TSA in patients who are suitable to undergo TSA at an outpatient ASC.

Level of Evidence:
Level II, Prospective cohort study.