bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequence stratigraphic framework of carbonates in mixed siliciclastic–carbonate sequences: local versus external controls in a tectonically active basin (Lorca Basin, Miocene, SE Spain)
Authors: Carpentier Cédric , Vennin Emmanuelle , Olivier Nicolas , Martin-Garin Bertrand 
Published: November 2024

ABSTRACT
The sequence stratigraphic framework of initiation and growth of carbonates in environments impacted by siliciclastic inputs is highly variable because of the biogenic nature of the sedimentary production and its sensitivity to environmental conditions. Using panorama interpretations, logging, and characterization of benthic communities, the mixed carbonate–siliciclastic sedimentary succession of the Neogene Lorca Basin (SE Spain) has been studied to decipher the role of local and global controlling parameters on the sequence stratigraphic framework of carbonate production. Three different carbonate depositional models are distinguished: 1) retrogradational homoclinal ramps (type 1) dominated by heterozoan communities that developed lateral to alluvial fans, 2) progradational flat-topped coral platforms (type 2) with Porites and Tarbellastraea coral carpets with a coeval retrogradational pattern on basin margins, and 3) retrogradational narrow siliciclastic-rich coral platforms (type 3) with Tarbellastraea buildups intercalated with deltaic deposits. Onset of carbonate production systematically occurred during transgressions controlled by eustasy and was locally enhanced by extensional tectonics. In steep margins located in the vicinity of major marginal faults, transgressions were characterized by high terrigenous inputs, and only heterozoan-dominated ramps (type 1) developed. The flooding of these steep and tectonically active margins characterized by small drainage basins and immature, locally sourced alluvial systems led to lower terrigenous fluxes and the growth of coral flat-topped platforms (type 2) during subsequent highstands. Away from main marginal faults, deltaic environments were sourced by large drainage basins. They were characterized by a flat topography that permitted the occurrence of a shallow photic zone subject to low and irregular terrigenous inputs up to the distal part of the depositional profile during transgressions. In this deltaic configuration, the growth of narrow siliciclastic-rich coral platforms (type 3) were favored. On these platforms, coral buildups were regularly buried by terrigenous inputs during highstands. In the Lorca Basin, the dimensions of siliciclastic systems and the size of their drainage basins also directly impacted the sequence stratigraphic framework of carbonates intercalated in terrigenous units. This study illustrates the marked variability in: 1) the different types of carbonate depositional profiles and 2) the timing of these carbonates in a mixed carbonate–siliciclastic system because of the size, maturity, and location of siliciclastic systems, local tectonics, inherited topography, and global sea-level fluctuations.
Predicting Photoelectric Logs in Challenging Conditions Using Machine Learning and Statistical Analysis
Authors: Abdullah Eassa , AlYami Reem 
Published: November 2024

Abstract
The photoelectric (PEF) log measures the photoelectric absorption factor, pivotal for determining rock matrix properties. High absorption factor values are typical in limestones, dolomites, clay, iron-bearing minerals, and heavy minerals, whereas sandstones exhibit lower values. In this study, actual photoelectric logs were gathered from the field alongside various other logs such as gallons per minute (GPM), standpipe pressure (SPP), rate of penetration (ROP), and bulk density (RHOB). Utilizing a suite of machine learning regression techniques—ridge regression, linear regression, support vector machines (SVM), polynomial regression, random forest, and decision tree—this research aimed to predict the photoelectric logs using porosity and other log data as inputs. The effectiveness of these models was confirmed through their strong predictive accuracy relative to actual log values. The ensemble of regression models demonstrated significant correlation coefficients and low root mean square errors, illustrating their robust capability to predict photoelectric data at various depths based on available drilling data.
Photonics-based Fully-Connected Hybrid Beamforming: Towards Scaling Up Massive MIMO at Higher Frequency Bands
Authors: Nichols Mitchell , Morison Hugh , Eshaghi Armaghan , Shastri Bhavin , Lampe Lutz 
Published: November 2024

Abstract

Wireless communication at higher frequency bands has attracted significant research interest for fifth generation and beoynd (5GB) wireless networks due to the large amount of unused bandwidth at these frequencies. However, there are substantial challenges associated with higher frequency bands due to the high path loss of the propagation environment and the high power consumption of the transceivers. Hybrid beamforming with massive multiple-input multiple-output (MIMO) has emerged as a solution to these problems by combining the performance and flexibility of digital beamforming with the energy efficiency of analog beamforming. Optical beamforming has recently been considered as an alternative to implement the analog component of a hybrid beamformer, which may offer improvements in size, weight and power consumption in comparison to conventional electronics. This paper proposes a new approach to implement an optical beamforming system based on photonic vector modulators using tunable photonic filters. Our experimental demonstration of the proposed optical beamformer shows that microring resonator (MRR)-based photonic vector modulators can be calibrated to achieve a root-mean-square (RMS) phase error of better than 2◦ and an amplitude error of 0.3 dB. Our findings identify a pathway to realize large scale, fully-connected hybrid beamformers by leveraging the compact and low loss photonics-based weight banks. The photonics-based beamformer can play a pivotal role in scaling up the number of antennas utilized to realize massive and extreme MIMO in 5GB. This is deemed essential specifically at higher frequency bands where conventional electronics fails.
Perioperative outcomes comparisons of thymoma treatment between robot-assisted thymectomy (RAT) and video-assisted thymectomy (VAT)：a meta-analysis
Authors: yu zipu , Jin Xiaoqiang , Zhang Yiran 
Published: November 2024

Abstract

AIM: To conduct a meta-analysis to determine the relative merits between robot-assisted thymectomy (RAT) and video-assisted thymectomy (VAT) in thymoma treatment.
METHODS:
A total of 1860 patients who underwent thymectomy were included in this study. A total of 897 patients underwent RAT, 963 patients underwent VAT. Perioperative outcomes were compared. Pooled odds ratio (OR) and standardized mean differences (SMDs) with 95% confidence intervals (95% CIs) were calculated using either the fixed effects model or the random effects model.
RESULTS: 15 studies were included with a total of 1860 patients, including 897 patients in the RAT group and 963 patients in the VAT group. Compared the perioperative outcomes with VAT, reports of RAT indicated favorable outcomes considering the hospital stay (SMD = -1.81, 95% CI -2.09 to -1.53), estimated blood loss (SMD = -12.55, 95% CI -16.68 to -8.42), duration of chest tube insertion (SMD = -0.47, 95% CI -0.63 to -0.31), volume of drainage (SMD = -79.79, 95% CI -90.72 to -68.86), conversion to open (OR= 0.32, 95% CI 0.18 to 0.58). Meanwhile, the sub-group meta-analysis for hospital stay indicated that RAT yielded a signiﬁcantly shorter time compared with VAT in non-Asian patients (OR= -19.56, 95% CI -29.73 to -9.39). Operative time and ICU stay with RAT were not signiﬁcantly different from VAT (SMD = 1.09; 95% CI -2.35 to 4.53; P = 0.53), (SMD = -0.13; 95% CI -0.32 to 0.06; P = 0.17). The mortality and complications （group and sub-group analysis） rates in both groups were comparable (OR 0.64, 95% CI 0.17–0.24; P = 0.52), (OR 0.92, 95% CI 0.48–1.77; P = 0.80).
CONCLUSION:
Our study suggests that the RATapproach is a feasible alternative approach and even a better option for thymoma surgery treatment. Further studies are required to confirm these results.
GNG2 inhibits brain metastases from colorectal cancer via cell cycle arrest and PI3K/Akt signaling pathway
Authors: Luo Chenhua , Xiao ZhiMing , Yang WenLong 
Published: November 2024

Abstract

G- protein gamma subunit 2 (GNG2) plays a vital role in various cellular processes, but its specific function in colorectal cancer (CRC), particularly in highly invasive cases and brain metastasis, remains unclear. In this study, GNG2 was identified as a key regulator in metastatic colorectal cancer (mCRC) through bioinformatics analysis and experimental validation. Functional enrichment analyses revealed that GNG2 is related to the PI3K/Akt signaling and cell cycle regulation. These findings were further validated by in vitro and in vivo experiments. GNG2 overexpression greatly suppressed proliferation and migration, inhibited the PI3K/Akt axis, and induced G0/G1 arrest in CRC cell lines. In vivo studies, orthotopic xenograft model demonstrated that GNG2 overexpression reduced brain metastasis and extended overall survival in mice. Immunohistochemistry and multiplex immunofluorescence confirmed the association between GNG2 overexpression, the PI3K/Akt signaling pathway, and G0/G1 arrest. Our study suggests that GNG2 contributes to tumor suppression in CRC, particularly in preventing brain metastasis, and could represent a promising biomarker and treatment target for mCRC, contributing fresh insights into the molecular processes driving cancer progression and metastasis.
Efficacy and safety of on-demand tegoprazan therapy in gastroesophageal reflux disease: A multicentre, double-blind, randomised, active-controlled pilot study
Authors: Kang Sun Hyung , Moon Hee Seok , Sung Jae Kyu , Kim Sun Moon , Kim Ki Bae , Lee Seung Woo , Cho Young Sin , Bang Ki Bae , Song Kyung Ho 
Published: November 2024

Abstract

Background
In patients with gastroesophageal reflux disease (GERD) whose symptoms improve with acid-suppression therapy, on-demand treatment could constitute maintenance therapy.
Aims
This study investigated the comparative efficacy and safety of on-demand tegoprazan and proton-pump inhibitor (PPI) therapy in GERD.
Methods
From six university hospitals in the Daejeon-Chungcheong region, we enrolled patients with GERD who had experienced symptomatic improvement with acid-suppressive therapy and, using a randomization table, randomly allocated these participants to two groups: to receive either tegoprazan 50 mg + esomeprazole placebo or tegoprazan placebo + esomeprazole 20 mg, respectively. The primary endpoint of this study was the intergroup difference in patient satisfaction with on-demand therapy.
Results
Among the 69 participants who completed 8 weeks of on-demand therapy and rated patient satisfaction on a 5-point Likert scale, the tegoprazan and esomeprazole groups scored an average of 4.31 and 4.15 points, respectively, without any significant intergroup difference. In the tegoprazan group, 26.2% (182/694) of those with episodes experienced symptom improvement within 30 minutes, which is a significantly higher proportion compared to 16.1% (104/646) in the esomeprazole group. Compared to the esomeprazole group, the tegoprazan group had a significantly shorter time to symptom improvement overall and a significantly higher proportion of patients who improved within 30 minutes. No serious treatment-emergent adverse events were reported.
Conclusion
Tegoprazan is effective as on-demand therapy for GERD and offers the expectation of faster symptom improvement than with PPIs. Clinical trial KCT0009296, registered at cris.nih.go.kr.
Environmental Impact of Disposable Face Masks: Degradation, Wear, and Cement Mortar Incorporation
Authors: Estevão Xiluva Maciel , Dias Ana Paula Soares , Flores-Colen Inês , Pereira Manuel Francisco Costa , Mendes Maria Paula 
Published: November 2024

Abstract

Polypropylene (PP) disposable face masks (DFMs) are essential for limiting airborne infectious diseases. This study examines the behavior of DFMs under three scenarios: i) exposure to the natural environment; ii) simulated high-energy aquatic environments through an abrasion test; and iii) incorporation into cement-based mortars. In the natural weathering experiment, after 117 days, the DFMs exhibited photodegradation, resulting in chemical alterations in carbonyl and hydroxyl groups. This degradation led to the breakdown of the polymer and the release of microplastics and nanoplastics. Controlled abrasion tests, conducted in a Denver ball with water, sand, and ceramic balls for 2 hours, confirmed that water is a critical factor for fiber release from DFMs. These tests resulted in the release of 0.26 g of PP fibers from 20 DFMs (weighing 62 g in total) with a diameter of 20 µm. Weathering and abrasion tests indicated rapid release and degradation of microplastics and nanoplastics, underscoring the importance of pursuing actions like reuse. Ecotoxicological tests revealed that leachates from the DFM-incorporated mortars showed no adverse effects on Daphnia magna or Selenastrum capricornutum, unlike the reference mortar, which caused substantial toxicity to Daphnia magna. Incorporating PP fibers from DFMs into cement-based mortars showed promising potential, as indicated by favorable ecotoxicity and chemical leaching test results.
Home-use Agents in the Treatment of Dentin Hypersensitivity: Clinical Efficacy Evaluation with Different Measurement Methods
Authors: AYAN Gizem , MİSİLLİ Tuğba , BULDUR Mehmet 
Published: November 2024

Abstract

Objectives: This study aimed to evaluate the effectiveness of home-use desensitizing agents over an 8-week period by comparing them using different measurement methods.
Methods: A randomized, controlled clinical trial was conducted with 180 individuals aged between 18-70 who clinically diagnosed DH in two or more non-adjacent teeth. Subjects who met the inclusion criteria (n=164) were randomly allocated into five test groups—using Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), Arginine, Novamin, Propolis, and Potassium nitrate—and a control group using standard fluoride toothpaste. Status of DH was assessed at week 4 and week 8 by the same independent examiner. Changes from baseline in Dentine Hypersensitivity Experience Questionnaire-15 (DHEQ-15), Schiff Sensitivity Scale (SSS) and Visual Analog Scale (VAS) were analysed using ANOVA and Kruskall Wallis tests.
Results: All test groups showed statistically significant improvements in DH at weeks 4 and 8 compared to baseline in the DHEQ-15, VAS, and SSS assessments (p<0.005). In the control group, significant improvements were observed only in the VAS and SSS measurements from baseline to weeks 8 (p<0.005). The CPP-ACP group demonstrated the greatest reduction in scores by the end of week 8 compared to baseline, with DHEQ-15 (56.68±17.87), VAS (6.52±1.48), and SSS (2.32±0.56).
Conclusions: Home-use desensitizing agents effectively treat DH, with the CPP-ACP group being the most effective and the Novamin group relatively less effective.
Clinical relevance: Some home-use desensitizing agents may be more effective in the treatment of DH. In particular, CPP-ACP can be recommended for patients with DH.
Trial registration: ClinicalTrials.gov Identifier: NCT06216262.
Diffuse Contribution of Organic Matter in the Mata dos Cocais Forest, Brazil
Authors: Feitosa Josiana do Nascimento Alves , Coelho Christine Farias , Silva Olga Aline Rodrigues da , De Araújo José Carlos 
Published: November 2024

Abstract

The diffuse contribution of organic matter to rivers, originated by natural weathering, impacts water quality and its monitoring and assessment are essential for hydro-environmental public policies. Yet, this information is unavailable for the Mata dos Cocais, an ecotone that links the Amazon, Caatinga and Cerrado biomes in Brazil. The experiments were carried during 12 months in the 3.53-km downstream reach of the 1540-km² Saco River basin. Mata dos Cocais receives large quantities of organic matter (0.261 mgBOD.L− 1km− 2; 1.22 mgBOD.L− 1km− 1). This outcome is similar to those of other tropical forests in Indonesia, Malaysia, and the Brazilian Cerrado.
Peripheral blood monocyte count impairs benefit from radiotherapy in patients with low gross tumor volume of nasopharyngeal carcinoma
Authors: Song Yun-Rui , Yang Li-Na , Li Dan , Lu Ming-Yue , Liu De-Qing , Tu Hong-Lei , sui Jiang-Dong , Xie Yue , Wang Ying 
Published: November 2024

Abstract

Background and purpose: The relationship between peripheral blood monocyte count and primary gross tumor volume with survival prognosis in newly diagnosed nasopharyngeal carcinoma(NPC) patients who received radiotherapy remains unclear. Therefore, We conducted a cohort study to assess the association of peripheral blood monocyte counts and primary gross tumor volume with survival outcomes in newly diagnosed non-metastatic NPC patients who received radiotherapy.
Materials/Methods: We included newly diagnosed non-metastatic NPC patients who underwent radiotherapy in our hospital from January 2013 to December 2015. General clinical characteristics such as age, gender, ECOG score and tumor stage, peripheral blood monocyte count, lymphocyte count, white blood cell count (WBC), neutrophil count, radiotherapy technology, total radiotherapy days, gross tumor volume of nasopharyngeal carcinoma (GTVnx) and gross tumor volume of cervix node(GTVnd) of patients before radiotherapy, and whether chemotherapy was induced were recorded. The primary endpoint was overall survival, the secondary endpoint was progression-free survival. Univariate and multivariate COX regression were used to analyze the relationship among peripheral blood monocyte count, GTVnx, and survival outcome. Based on the independent risk factors for OS, we further divide patients into three different risk groups, and the differences in clinical and therapeutic indicators and survival outcomes between the three groups were analyzed using a one-way analysis of variance.
Results: A total of 448 participants were included in the study, the median follow-up time was 74.3 months. Of these, 97 (21.7%) died. In the univariate and multivariate Cox regression analyses, peripheral blood monocyte count and GTVnx were independently associated with OS. The high monocyte count and GTVnx were associated with the poor OS and PFS. Survival curves significantly differed among patients in different risk groups for OS (p = 0.0008) and PFS (p = 0.0007). Besides, For every increase in monocyte unit count, the OS and PFS risks of patients in the low GTVnx group increased by 2.64 and 2.31 folds, respectively,.
Conclusions: Peripheral blood monocyte count combined with GTVnx is a independent predictor for overall survival and progression free-survival in newly diagnosed non-metastatic NPC patients who received radiotherapy. The benefit of patients with GTVnx< 28.5cm3 could be remarkably attenuated by the high monocyte count.
Predictive Value of Body Temperature in the Development of Intracranial Infections in Postoperative Patients with Acute Intracerebral Hemorrhage
Authors: Bu Wei , Liang JinQuan , Han Xipeng , Hu Yucheng , Zhang Zhaojun , Zhang Cheng , Shao Min 
Published: November 2024

Abstract

Background
Intracranial infections are among the most severe complications following surgery for acute Intracerebral Hemorrhage (ICH). Study aims to explore link between body temp changes and intracranial infections post-ICH surgery.
Methods
This retrospective study based on whether intracranial infections occurred postoperatively, the 209 patients were categorized into two groups. According to the analysis results of temperature variation trends within 7 days post-surgery for the two patient groups, we employed restricted cubic spline (RCS) and receiver operating characteristic (ROC) curve analysis to evaluate the predictive value of the peak body temperature on the third day for intracranial infection.
Results
Compared to the control group, the intracranial infection group exhibited significantly higher peak temperatures from postoperative day 3, and the difference persisted until postoperative day 7. According to the RCS analysis results, on the 3rd day postoperatively, peak body temperature correlated linearly and positively with intracranial infection. Patients in the high-risk group with a peak body temperature of ≥ 38.2 ℃ on the third day exhibited a significantly higher incidence of intracranial infection (P = 0.005), longer duration of mechanical ventilation and ICU stay.
Conclusions
Our findings preliminarily elucidated the correlation between temperature changes and intracranial infection in postoperative patients with ICH, aiding early warning.
Factors Associated with Treatment Response in Chronic Nonbacterial Osteomyelitis at a Single Center: A Retrospective Cohort Study
Authors: Nowicki Katherine D , Rogers Nathan D , Keeter Carson L , Donaldson Nathan J , Soep Jennifer B , Zhao Yongdong 
Published: November 2024

Abstract

Background NSAIDs are commonly used as first line therapy in chronic nonbacterial osteomyelitis (CNO) but are not effective for all patients. The objective of this study was to identify clinical variables associated with NSAID monotherapy response versus requiring second-line medication in a single-center cohort of patients with CNO.Methods The charts of children with CNO who attended a CNO clinic at a quaternary care center between 1/1/05 and 7/31/21 were retrospectively reviewed. Patients were divided into 3 groups: NSAID-short (NSAID monotherapy for 3 to < 7 months), NSAID-long (NSAID monotherapy for ≥ 7 months), or second-line treatment. Patients were also categorized by which bodily regions were affected by CNO. Multiple linear and logistic regression models were constructed to predict total NSAID monotherapy days and the odds of needing second-line treatment, respectively. These models were optimized using variable combinations that minimized multicollinearity and maximized predictive power, as indicated by minimized AIC values.Results One-hundred-sixty-four patients fulfilled inclusion criteria. Thirty-two patients were in the NSAID-short group, 62 in the NSAID-long group, and 70 in the second-line treatment group. Comparing the two NSAID groups showed that patients with unifocal disease at diagnosis required 47% fewer days of NSAIDs than those with multifocal disease. Results from logistic regression indicated that for each additional region affected, the odds of needing second line treatment increased by 1.94 times (p = 0.01) and that patients with symmetric bone lesions were 6.86 times more likely to require second-line treatment (p < 0.001).Conclusions Patients with unifocal CNO involvement at diagnosis were more likely to require shorter NSAID treatment. Patients with more regions affected and those with symmetric bone lesions were more likely to require second-line treatment.