bluuebunny/crossref_metadata_2025_split huggingface dataset:
TGFβ2‐Driven Ferritin Degradation and Subsequent Ferroptosis Underlie Salivary Gland Dysfunction in Postmenopausal Conditions
Authors: Oh Su‐Jeong , Shin Ye Young , Ahn Ji‐Su , Park Hee‐Jeong , Kang Min‐Jung , Shin Tae‐Hoon , Lee Byung‐Chul , Kim Won Kyu , Oh Jung‐Min , Lee Dongjun , Kim Yun Hak , Kim Ji Min , Sung Eui‐Suk , Lee Eun‐Woo , Jeong Jee‐Heon , Lee Byung‐Joo , Seo Yoojin , Kim Hyung‐Sik 
Published: October 2024

AbstractDespite the high incidence of dry mouth in postmenopausal women, its underlying mechanisms and therapeutic interventions remain underexplored. Using ovariectomized (OVX) mouse models, here this study identifies ferroptosis, an iron‐dependent regulated cell death, as a central mechanism driving postmenopausal salivary gland (SG) dysfunction. In the OVX‐SGs, TGFβ signaling pathway is enhanced with the aberrant TGFβ2 expression in SG mesenchymal cells. Intriguingly, TGFβ2 treatment reduces iron‐storing ferritin levels, leading to lipid peroxidation and ferroptotic death in SG epithelial organoids (SGOs). Mechanistically, TGFβ2 promotes the autophagy‐mediated ferritin degradation, so‐called ferritinophagy. A notable overexpression of the type III TGFβ receptor (TβRIII) is found in the OVX‐SGs and TGFβ2‐treated SGOs, while the silencing of TβRIII mitigates the ferroptosis‐mediated deleterious effects of TGFβ2 on SGOs. Finally, administration of ferroptosis inhibitor, Liproxstatin‐1 (Lip‐1), improves saliva secretion in OVX mice. Present findings collectively suggest a link between TGFβ signaling, ferroptosis, and SG injury, offering new therapeutic avenues for postmenopausal xerostomia.
Reviving Spent NCM Cathodes via Spontaneous Galvanic Corrosion in Ambient Atmospheric Condition
Authors: Song Jinju , Song Hayong , Song Jeonghwan , Noh Geumui , Kim Hyungsub , Ma Jiyoung , Woo Jung‐Je 
Published: October 2024

AbstractThe recycling of end‐of‐life Li‐ion batteries (EoL LIBs) is critical for maintaining the sustainable LIB industry. In this study, the compositional restoration method for degraded LiΔNi0.6Co0.2Mn0.2O2 cathode via spontaneous galvanic corrosion, which can be conducted at room temperature, is demonstrated. Achieving the lithiation of spent LiΔNi0.6Co0.2Mn0.2O2 to its pristine state at room temperature requires a strong reducing agent with a redox potential lower than 1.6 V (vs Li/Li+), which is very reactive and expensive. In the designed restoration system, spontaneous restoration can be achieved by using an Aluminum (Al) current collector as a reducing agent which has sufficient reducing power (Al/Al3+, 1.37 V (vs Li/Li+)). Moreover, through a galvanic reaction design that utilizes Li‐ion in the electrolyte of spent LIBs, the additional Li source required to replenish the Li‐deficient NCM is minimized. The galvanic corrosion‐based restoration mechanism is systematically analyzed, and a spent Li0.76Ni0.6Co0.2Mn0.2O2 is successfully restored to its pristine state (Li1.05Ni0.6Co0.2Mn0.2O2). Furthermore, restoration strategies accomplishable in not only the cathode state but also the battery state are presented to ensure applicability in practical recycling processes. The proposed strategy suggests a new insight into the direct cathode recycling technology, possessing economic feasibility, and environmental friendliness.
Animal Welfare or Own Welfare: What Motivates Consumers’ Choice of Cage‐Free Products?
Authors: He Juan , Xiong Hang 
Published: October 2024

ABSTRACTThis study addresses the puzzle of animal welfare regulations consistently passing by majority votes, despite potential welfare losses evident in market data. To understand this phenomenon, we propose a conceptual framework that considers two possibilities: first, animal welfare might not be valued in the market, as suggested by classical externality analysis, and second, it could be valued due to altruistic motivations. To illustrate the framework, we uncover the motives driving consumers’ demand for animal welfare products jointly utilizing the results of a discrete choice experiment and respondents’ perception data obtained in China. Our findings align with the predictions made by classical externality analysis, indicating that the public good aspect of animal welfare is not valued in this market and thereby challenging the existence of altruistic behavior. Moreover, our analysis of consumer heterogeneity reveals that as consumers’ knowledge increases, they exhibit a decreased inclination to prioritize the animal welfare attribute for fulfilling their private needs, and may raise concerns about the safety of animal welfare‐friendly products.
Biomimetic Triplet Messenger RNA Formulation in MXene Hydrogel Microneedles for Wound Healing
Authors: Wang Ji , Wang Yu , Lu Minhui , Cao Xinyue , Xia Ming , Zhao Miaoqing , Zhao Yuanjin 
Published: October 2024

ABSTRACTMessenger RNA (mRNA) has demonstrated immense potential in disease therapeutic applications. The current direction is focused on imparting mRNA with competitive synthetic functions and delicate carrier systems. Here, inspired by the collaborative regulation of growth factors by the cellular microenvironment, we present novel transition metal carbide/nitride (MXene) hydrogel microneedles loaded with a biomimetic triplet mRNA formulation (TM) for diabetic wound treatment. Such microneedles were composed of TM, MXene, and hyaluronic acid hydrogel. The presence of MXene imparted the microneedles with great photo‐thermal responsiveness properties, thus realizing controlled active release by the shrinkage/swelling of hydrogel. With the effective release of TM, the microneedles were proven to enhance endothelial cell migration, growth, and angiogenesis. Through in vivo animal experiments, we have confirmed that TM‐microneedles (TM‐MNs) can promote tissue regeneration and collagen deposition more effectively than intravenous and intradermal administration. Thus, we believe that the proposed TM‐MN platform with precise delivery and controllable release of TM will show great potential for promoting the healing of clinic diabetic wounds.
Health behaviours and affective states of partners of fly‐in fly‐out workers: A daily diary study
Authors: Asiamah‐Asare Bernard Kwadwo Yeboah , Robinson Suzanne , Kwasnicka Dominika , Powell Daniel 
Published: October 2024

AbstractPartners of fly‐in fly‐out (FIFO) workers face increases in demands, for instance in care and family responsibilities, particularly in the absence of workers; however, little is known about how their daily life experiences influence their health across the FIFO work cycle. This study examined the within‐person effects of workload, job control and social support on affective states and health behaviours of partners of FIFO workers. Forty‐four (N = 44) partners of FIFO workers completed online diary surveys on affective states and health behaviours once a day for 28 consecutive days during on‐and off‐shift periods of the FIFO worker. Multilevel models were used to analyse day‐level data. The results of the study demonstrated significant differences in partners' depressed affect and alcohol consumption during both on‐ and off‐shift periods of FIFO workers. Daily increases in workload were associated with anxious affect, whereas daily increases in job control and social support were associated with low depressed affect and positive affect in partners of FIFO workers. Daily increase in social support was also found to be associated with an increase in daily alcohol intake. Interventions could support partners in managing the daily workload and encouraging the creation of social support networks in partners of FIFO workers.
Natural Polyphenol‐Reinforced Ion‐Selective Separators for High‐Performance Lithium‐Sulfur Batteries with High Sulfur Loading and Lean Electrolyte
Authors: Yang Yanfei , Wang Wankai , Zhang Junping 
Published: October 2024

AbstractIon‐selective separators are promising to inhibit soluble intermediates shuttle in practical lithium‐sulfur (Li−S) batteries. However, designing and fabricating such high‐performance ion‐selective separators using cost‐effective, eco‐friendly, and versatile methods remains a formidable challenge. Here we present ion‐selective separators fabricated via the spontaneous deposition of green tea‐derived polyphenols onto a polypropylene separator, aimed at enhancing the stability of Li−S batteries. The resulting natural polyphenol‐reinforced ion‐selective (NPRIS24) separators exhibit rapid Li ion transport and high soluble intermediates inhibition capability with an ultralow shuttle rate of 0.67 % for Li2S4, 0.19 % for Li2S6 and 0.10 % for Li2S8. This superior ion‐selectivity arises from the high electronegativity and strong lithiophilic nature of the phenolic compounds. Consequently, we have achieved high‐performance Li−S batteries that are steadily cyclable under the challenging conditions of an S loading of 5.7 mg cm−2, an electrolyte‐to‐S ratio of 5.1 μL mg−1, and a 50 μm Li foil anode. Furthermore, the NPRIS24 separator enhances the performance of other Li metal batteries utilizing commercial LiFePO4 (5.3 mg cm−2) and LiNi0.5Co0.2Mn0.3O2 (9.9 mg cm−2) cathodes. This work underscores the potential of utilizing natural polyphenols for the design of advanced ion‐selective separators in energy storage systems.
Homologation of Alkenyl Carbonyls via a Cyclopropanation/Light‐Mediated Selective C−C Cleavage Strategy
Authors: Nguyen Tin V. T. , Brownsey Duncan K. , Bossonnet André , Wodrich Matthew D. , Waser Jerome 
Published: October 2024

AbstractWe report herein our studies on the direct photoactivation of carbonyl cyclopropanes to give biradical intermediates, leading to selective cleavage of the more substituted carbon‐carbon bond. Depending on the substrate structure, extended alkenes were isolated or directly reacted in a photo‐Nazarov process to give bicyclic products. Based on these results, a unified reductive ring‐opening reaction was developed by using diphenyl disulfide as a hydrogen atom transfer (HAT) reagent. By performing a sequential cyclopropanation/selective ring opening reaction, we achieved a CH2 insertion into the α,β bond of both acyclic and cyclic unsaturated carbonyl compounds. Our protocol provides a further tool for the modification of the carbon framework of organic compounds, complementing the recent progress in “skeletal editing”.
Copper‐Catalyzed C(sp3)−H α‐Acetylation: Generation of Quaternary Centers
Authors: Okoromoba Otome E. , Chen Ting‐An , Jang Eun Sil , McMullin Claire L. , Cundari Thomas R. , Warren Timothy H. 
Published: October 2024

Abstractα‐substituted ketones are important chemical targets as synthetic intermediates as well as functionalities in natural products and pharmaceuticals. We report the α‐acetylation of C(sp3)−H substrates R−H with arylmethyl ketones ArC(O)Me to provide α‐alkylated ketones ArC(O)CH2R at RT with tBuOOtBu as oxidant via copper(I)
‐diketiminato catalysts. Proceeding via alkyl radicals R•, this method enables α‐substitution with bulky substituents without competing elimination that occurs in more traditional alkylation reactions between enolates and alkyl electrophiles. DFT studies suggest the intermediacy of copper(II) enolates [CuII](CH2C(O)Ar) that capture alkyl radicals R• to give R−CH2C(O)Ar outcompeting dimerization of the copper(II) enolate to give the 1,4‐diketone ArC(O)CH2CH2C(O)Ar.
Natural Surface Frustrated Lewis Pairs: The Concept and Beyond
Authors: Yu Xi‐Yang , Su Xue , Xi Meng‐Jia , Huang Zheng‐Qing , Chang Chun‐Ran 
Published: October 2024

AbstractThe reusable and separable surface frustrated Lewis pairs (SFLPs) open up a novel approach to efficient small‐molecule activation and conversion in heterogeneous catalysis. However, SFLPs have only been reported on limited systems due to the difficulty in the design and synthesis process. The inherent Lewis pairs on various solid materials offer promising opportunities for finding natural SFLPs, providing a straightforward and efficient strategy to overcome the current limitations. In this concept, we retrospect the concept of natural SFLPs proposed on wurtzite crystal surfaces and identify other natural SFLPs that probably exist on solid materials, including reduced oxide surfaces, corrugated graphene, and perovskite quantum dots. Having focused on the reactivity of natural SFLPs in small‐molecule activation, we discuss the current challenges, propose possible research directions, and highlight potential applications of natural SFLPs in heterogeneous catalysis.
Design and Development of Infiltration Resins: From Base Monomer Structure to Resin Properties
Authors: Yang Shuo , Zhao Ting , Liu Xiaoqiu , Zhang Haibo , Yang Bo , Chen Zheng 
Published: October 2024

AbstractThe resin infiltration concept is one of the most widely used minimally invasive restorative techniques in restorative dentistry with the most outstanding therapeutic effect, and it is also one of the key research directions in restorative dentistry. “Infiltration resin” is the specialty restorative material for the technology, which is the key factor to success. The specialized restorative material is commonly known as “infiltrant/infiltration resins” “resins infiltrant” “infiltrant” or “resins,” which will be consistently referred to as “infiltration resins” throughout the article. The paper aims to provide a comprehensive overview of infiltration resins by introducing the development of their therapeutic mechanisms, basic components, current challenges, and future trends, Based on existing literature, we analyze and compare how changes in the base monomer's structure and ratio affect the effectiveness of infiltration resins, from the material's structure‐effective relationship. After compiling the information, the existing solution strategies have been listed to offer substantial support and guidance for future research endeavors.
Probing the Propeller Regime With Wide Neutron Star Binaries
Authors: Afonina M. D. , Popov S. B. 
Published: October 2024

ABSTRACTWe model the duration of the propeller stage in wide binary systems with neutron stars and calculate the time of accretion onset for various propeller models. We apply our modeling to the symbiotic X‐ray binary SWIFT J0850.8‐4219. Unless a propeller with a very slow spin‐down is operating, it is very improbable to find a system similar to SWIFT J0850.8‐4219 at the propeller stage. Then we model the evolution of a neutron star in a binary with a solar‐like companion. We calculate for which orbital separations and magnetic fields a neutron star can start to accrete while the companion is still on the Main sequence. We demonstrate that for the magnetic field G neutron stars at the orbital separation AU do not reach the propeller stage. In the case of a slow propeller spin‐down, neutron stars never start to accrete. For the more rapid propeller spin‐down, a neutron star can start to accrete or spend a long time at the propeller stage depending on the parameters.
Optimierung des Verfahrens zur Einflusslinienberechnung aus Messdaten
Authors: Oberwestberg Mattis , Pitters Sarah , Flack Christian , Niebuhr Peter Lothar , Wüchner Roland 
Published: October 2024

AbstractIm Rahmen der messwertgestützten Nachrechnung von Eisenbahnbrücken in Stahlbauweise wird für die Ermittlung der Tragwerksbeanspruchung die Berechnung von Einflusslinien infolge der Überfahrt eines Belastungsfahrzeugs verwendet. Das gängige Verfahren zur Bestimmung von Einflusslinien aus Messdaten ist das Verfahren nach Braune, welches die Einflusslinie schrittweise aus den Messdaten errechnet. In diesem Aufsatz wird mit dem Matrixverfahren ein alternatives Verfahren zur Einflusslinienermittlung erläutert und mit dem Verfahren nach Braune verglichen. Dazu wurden unterschiedliche Einflussfaktoren auf die Ergebnisqualität der Einflusslinien anhand von künstlichen, am statischen Modell der Eisenbahnüberführung Norderelbe generierten Dehnungslinien untersucht und unter Verwendung von im Zuge der Nachrechnung der Brücke gewonnenen Messdaten validiert. Die Untersuchungen zeigen, dass das Matrixverfahren eine robuste Methode zur Ermittlung von Einflusslinien darstellt und der Arbeitsaufwand im Vergleich zu dem Verfahren nach Braune reduziert werden kann. Darüber hinaus ist das Matrixverfahren flexibel in den bestehenden Arbeitsprozess der Einflusslinienermittlung integrierbar.
Binding of a Drug (Colchicine) to L‐Asparaginase Enzyme Using Multispectroscopic, Thermodynamics, and Simulation Studies: Possible Implication in Acute Lymphoblastic Leukemia Treatment
Authors: Abdullah Ejlal Mohamed , Ataya Farid Shokry , Rehman Md. Tabish , Arshad Mohammed , Al Kheraif Abdul Aziz , Al‐twaijry Nojood , Alshammari Atekah Hazza , AlAjmi Mohammad F. , Alokail Majed S. , Khan Mohd Shahnawaz 
Published: October 2024

ABSTRACTThe research aims to elucidate how drug interactions affect the activity of L‐asparaginase (L‐ASNase), an essential enzyme in cancer treatment, especially for acute lymphoblastic leukemia (ALL). Understanding these interactions is crucial for optimizing treatment effectiveness and reducing adverse effects. This study explores the intricate molecular interactions and structural dynamics of L‐ASNase upon binding with colchicine. Fluorescence quenching experiments were conducted at various temperatures (298, 303, and 310 K), revealing notable interactions between L‐ASNase and colchicine. These interactions were characterized by a reduction in fluorescence intensity and a blue shift in emission maxima. Additional analyses, including the determination of Stern–Volmer quenching constants (KSV), bimolecular quenching rate constants (kq), and thermodynamic parameters, indicated a static quenching mechanism with moderate binding affinities (Ka: 1.40–2.71 × 104 M−1) across different temperatures. Thermodynamic study suggested positive enthalpy and entropy changes (ΔH° = −10.26 kcal mol−1; ΔS° = −14.19 cal mol−1 K−1), suggesting a spontaneous reaction with negative ΔG° values (−5.86 to −6.03 kcal mol−1). FRET measurements supported optimal distances (r and Ro) for FRET occurrence, reinforcing the static quenching mechanism. Molecular docking further supported these findings, revealing a 1:1 stoichiometric binding ratio for L‐ASNase:colchicine and elucidating specific binding orientations and interactions critical for complex stability. Subsequent molecular dynamics simulations spanning 100 ns underscored the stability of the L‐ASNase–colchicine complex, with minimal deviations observed in key structural parameters such as RMSD, RMSF, Rg, and SASA. Additionally, spectroscopic analyses, including circular dichroism (CD), synchronous fluorescence, and 3D fluorescence provided insights into the conformational changes and alterations in the microenvironment of aromatic amino acid residues in L‐ASNase upon colchicine binding. Moreover, L‐ASNase activity was slightly reduced by 25% in the presence of colchicine. This comprehensive investigation sheds light on the molecular intricacies of the L‐ASNase–colchicine complex, advancing our understanding of drug–target interactions and offering potential avenues for therapeutic applications.
Fluorescent Microscopy Investigation of Cytotoxic Impact on MCF‐7 Cell Line Treated With Zinc Nanoparticles Synthesized From Jania rubens
Authors: Rajasekaran Duraisamy , Sathishkumar Pomman , Neelakandan Mani , Revathi Kannan , Kumar Jothi Vinoth , Srinivasan P. , Devanesan Sandhanasamy , Selvamaleeswaran Ponnusamy 
Published: October 2024

ABSTRACTZinc nanoparticles (ZnNPs) are a viable option in a number of disciplines, including cancer treatment, due to their special features. Among the several techniques for synthesizing ZnNP, biosynthesis with natural extracts is a highly effective and environmentally benign method, especially for uses in biomedicine. Using an aqueous extract of the marine red seaweed Jania rubens, we created a unique biosynthetic technique in this study to manufacture ZnNPs. The produced ZnNPs have a characteristic flower‐like form, as seen by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The effective production of ZnNPs and the involvement of biomolecules in the synthesis process were validated by energy‐dispersive X‐ray spectroscopy (EDAX) and Fourier transform infrared spectroscopy (FTIR) techniques. Using the MTT assay, the cytotoxic effects of the biosynthesized ZnNPs were evaluated, indicating their ability to inhibit MCF‐7 breast cancer cells. Furthermore, ZnNPs' cytotoxicity against MCF‐7 cells was validated by live/dead imaging experiments, which supported the MTT results.
Beyond aroma: A sustainability performance analysis of Italian coffee roasting companies
Authors: Triachini Sara , Giannini Francesca Romana , Bramanti Valentina , Gubelli Stella , Capri Ettore 
Published: October 2024

AbstractCoffee consumption is becoming increasingly prevalent among a growing number of consumers worldwide. Despite ranking seventh in coffee consumption, Italy is the global coffee export leader, with almost 1000 coffee roasting companies across the country. As a product subject to increasing interest in sustainability, numerous studies address the economic, social and environmental challenges affecting coffee production. However, only a few evaluate the sustainability performance of roasting companies in consuming countries. This study examines the integration of corporate social responsibility (CSR) in business strategy to provide an overview of sustainability performance among Italian roasting companies. The analysis encompasses 78 sustainability practices across 49 businesses and assesses their communication to stakeholders. Furthermore, factors such as company size and specialty coffee sale were investigated for their influence on sustainability performance. The findings reveal a low commitment to sustainability within the Italian coffee sector, with 83.7% of companies in the first two stages of the five‐stage CSR assessment model. Although there is an interest in addressing product safety, quality, and consumer relations, responsible sourcing is often relegated to suppliers or voluntary sustainability standards. Communication is not effective, as more than half of the companies did not provide sustainability information on their websites. In this sample, the commitment to sustainability was directly related to the size of the business, and the same relationship was observed for roasters selling specialty coffees.
Psychological Ownership of Avatars in the Metaverse: Its Key Antecedents and Outcomes
Authors: Park Jinsu , Kim Hye‐Young 
Published: October 2024

ABSTRACTThis study developed and tested a model exploring the antecedents and outcomes of psychological ownership of avatars in the metaverse, considering the moderating role of virtual currency acquisition methods. Using data from 252 ZEPETO users and Partial Least Square‐Structural Equation Modeling (PLS‐SEM), the study found that the ability to control, intimate knowledge, and invest in self significantly enhances psychological ownership of avatars, which extends to virtual products. Notably, the reward system (versus direct purchase) for acquiring virtual currency amplified this ownership extension, and the transference of psychological ownership from avatars to virtual products significantly influenced the intention to purchase corresponding real‐world products. The study underscores the interplay between virtual and real‐world dynamics, highlighting the impact of digital activities on real‐world consumer behavior.