bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequential Hemodynamic Analysis of Ruptured Posterior Communicating Artery Aneurysms Treated With Coil Embolization and Delayed Flow Diversion
Authors: Ramirez-Velandia Felipe , Loly Vincenzo T. R. , Enriquez-Marulanda Alejandro , Young Michael , Tatit Rafael T. , Cintra Arthur , Baccin Carlos E. , Shutran Max , Taussky Philipp , Ogilvy Christopher S. 
Published: November 2024

BACKGROUND AND OBJECTIVES:
Computational fluid dynamics has advanced our knowledge of the pathogenesis of intracranial aneurysms and the dynamic changes observed after treatment. Herein, we analyze hemodynamic changes throughout the intervention stages for ruptured posterior communicating artery (PComA) aneurysms, treated with acute coiling and delayed flow diversion (FD).

METHODS:
We performed a retrospective analysis of ruptured PComA aneurysms treated with the acute coiling and delayed FD strategy between June 2013 to November 2022, using 3-dimensional reconstructions of digital subtraction angiographies. Hemodynamic simulations using ANSYS® calculated aneurysmal and adjacent arteries' wall shear stress (WSS), aneurysmal low shear areas (LSA), and mean velocities in the distal arteries.

RESULTS:
Six of the 22 patients were selected for computational fluid dynamics analysis, including 4 females and 2 males with a median age of 60 years. The average aneurysm volume was 984.12 mm3, with an average surface area of 386.11 mm2; LSA was 22.90%, and the average WSS was 3.39 Pa. The 2 largest aneurysms also had the highest LSA values. After coiling, there was a reduction in the aneurysmal volume (−78.42%) and the average surface area (−55.28%), and aneurysmal WSS increased to 6.10 Pa (+79.90%). WSS values for the middle cerebral artery (MCA) increased to 10.76 Pa, while anterior cerebral artery (ACA) increased to 7.51 Pa. Complete occlusion was achieved with delayed FD at a median follow-up of 19.7 months. After FD, average WSS increased to 14.94 Pa for the MCA (+70.64%) and to 10.82 Pa for the ACA (+30.10%). The mean MCA velocity increased to 43.04 cm/s (+36.85%), and 3 cases showed an increase in ACA velocities.

CONCLUSION:
LSA may have triggered rupture for the PComA aneurysms analyzed. After coiling, average WSS increased in the aneurysm wall and downstream vessels in the majority of cases analyzed. Delayed FD caused hemodynamic disturbances distal to deployment, reflected in the sequential increase in the WSS and velocities in both the ACA and MCA.
Distinct effects of CDK8 module subunits on cellular growth and proliferation in Drosophila
Authors: Li Xiao , Liu Mengmeng , Xing Yue , Niu Ye , Liu Tzu-Hao , Sun Jasmine L. , Liu Yanwu , Hemba-Waduge Rajitha-Udakara-Sampath , Ji Jun-Yuan 
Published: November 2024

ABSTRACT
The Mediator complex plays a pivotal role in facilitating RNA polymerase II-dependent transcription in eukaryotes. Within this complex, the CDK8 kinase module (CKM), comprising CDK8, Cyclin C (CycC), Med12 and Med13, serves as a dissociable subcomplex that modulates the activity of the small Mediator complex. Genetic studies in Drosophila have revealed distinct phenotypes associated with mutations in CKM subunits, but the underlying mechanisms have remained unclear. Using Drosophila as a model, we generated transgenic strains to deplete individually or simultaneously the four CKM subunits in all possible combinations, uncovering unique phenotypes in the eyes and wings. Depletion of CDK8-CycC enhanced E2F1 target gene expression and promoted cell-cycle progression, whereas Med12-Med13 depletion had no significant impact on these processes. Instead, depleting Med12-Med13 altered the expression of ribosomal protein genes and fibrillarin, and reduced nascent protein synthesis, indicating a severe reduction in ribosome biogenesis and cellular growth compared to the loss of CDK8-CycC. These findings reveal distinct in vivo roles for CKM subunits, with Med12-Med13 disruption having a more pronounced effect on ribosome biogenesis and protein synthesis than CDK8-CycC loss.
Ten-Year Outcome of a Randomized Trial: Cytoreduction and HIPEC with Mitomycin C Versus Oxaliplatin for Appendiceal Neoplasm with Peritoneal Dissemination
Authors: Levine Edward A. , Cos Heidy , Votanopoulos Konstantinos I. , Shen Perry , Russell Greg , Mansfield Paul , Fournier Keith , Bartlett David , Stewart John H. 
Published: November 2024

Abstract
Background
Appendiceal cancer is a rare disease that has proven difficult to study in prospectively. Our initial report of this trial showed minor hematologic toxicity with both mitomycin C and oxaliplatin and similar 3-year survival. We now report an update of the first prospective randomized trial for appendiceal cancer with 10-year follow up.

Patients and Methods
Patients with mucinous appendiceal neoplasms and evidence of peritoneal dissemination were enrolled in the Multicenter Randomized Trial to evaluating HIPEC for 120 min with oxaliplatin (200 mg/M2) or mitomycin C (40 mg). Overall survival and disease-free survival were calculated at 10 years and compared between the groups.

Results
A total of 121 patients were included in the study. The patients were 57% female, with a mean age of 55.3 years (range 22–82 years). The disease was low grade in 71% and high grade in 29%. The average peritoneal cancer index (PCI) score was 18 (SD 10) in the mitomycin C group and 17.9 (SD 9.4) in the oxaliplatin group (p = 0.94). The 10-year survival rate was 56.2% (SE 7.2) with mitomycin C and 47.5% (SE 8.4) with oxaliplatin, p = 0.83. The 10-year progression-free survival rate in the mitomycin C group was 45.2% (SE 8.4) compared with 50.4% (SE 6.7) in the oxaliplatin group, p = 0.95. Median survival was 9.1 years after HIPEC with oxaliplatin, and median not reached for the mitomycin C group (> 5.6 years).

Conclusions
Oxaliplatin and mitomycin C have similar long-term efficacy for hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with appendiceal neoplasms and peritoneal dissemination. Long-term survival is experienced by most patients after cytoreduction surgery (CRS) and HIPEC for appendiceal neoplasms.
North Sumatra Busedah to strengthen students’ character and implementation through the fun school
Authors: Moningka Yudha , Aprilia Nani , Isnaeni Bekti 
Published: November 2024

Strengthening character education still needs to be done because it has been found that student's behavior is not according to applicable norms and rules. History education is one of the subjects that can potentially strengthen character education. The formulation of this research is "How is the design of North Sumatra Busedah to strengthen the character education of students and its implementation through the fun school movement?". The purpose of this research is to analyze the design of North Sumatra Busedah to strengthen the character education of students and its implementation through the fun school movement. This type of research is descriptive research. The data collection techniques used are observation and documentation. The data collection instruments used were observation sheets and history books. The research procedure was carried out by analyzing the material content in the history book used by the teacher. Then, researchers designed a new history book, North Sumatra Busedah as a renewal of history books that contained material about the history of North Sumatra. Furthermore, researchers examined the challenges that would be faced in implementing North Sumatra Busedah through the fun school movement. The results showed that researchers designed the creation of North Sumatra Busedah as a history book renewal which was adjusted to the learning outcomes in phases E and F. 2 possible challenges will be faced in implementing North Sumatra Busedah to strengthen the character education of students through the fun school movement.
The possible role of iodinated contrast in enhancing acute kidney injury in a critically ill neonate – a case report
Authors: Matos Wevelin Santos de , Ramalho Fernando Silva , Facincani Inalda , Manso Paulo Henrique 
Published: November 2024

A multi-modality approach is necessary for accurate diagnosis in case of congenital heart diseases present in the neonatal period. Advances in medical imaging have increased dependence on the information provided by radiological studies. However, several of these studies require the use of contrast, which may enhance the risk of contrast-induced acute kidney injury. We report on a case of a neonate with transposition of great arteries who was submitted to iodinated contrast during angiotomography. Soon after the procedure, he presented anuria and increased urea and creatinine levels, and was diagnosed with a contrast-induced acute kidney injury. Despite the use of peritoneal dialysis, he died soon thereafter. Post mortem analysis showed extensive coagulative necrosis in the renal cortical and medullary layers.
Intensity correlations of light waves scattered by random media having parity-time symmetry
Authors: Yue Jiaxin , Wu Gaofeng , Wang Fei , Cai Yangjian 
Published: November 2024

Light waves scattered by random media with parity-time (PT) symmetry exhibit unique second-order statistical characteristics in the far field [Phys. Rev. A 105, 023510 (2022)PLRAAN1050-294710.1103/PhysRevA.105.023510]; however, the nature of its higher-order statistics remains unexplored. This paper aims to analyze the intensity correlation (IC), i.e., fourth-order statistics, of a normally incident plane wave scattered by PT-symmetric random media. By utilizing the first-order Born approximation, we analytically show that this type of PT symmetry causes the spatial profile of the IC function of scattered light to split into three parts in the far zone. Moreover, this IC profile rotates with respect to its reference spatial point as the gain and loss of scatterers vary. These findings suggest an effective approach to detect the random medium’s gain or loss properties by measuring the IC distribution of scattered light in the far zone.
Gadolinium-doped carbon dots with long-wavelength emission for dual-modal imaging
Authors: Efimova Arina A. , Badrieva Zilya F. , Brui Ekaterina A. , Miruschenko Mikhail D. , Aleinik Ivan A. , Mitroshin Alexander M. , Volina Olga V. , Koroleva Aleksandra V. , Zhizhin Evgeniy V. , Stepanidenko Evgeniia A. , Ushakova Elena V. 
Published: November 2024

Subject of study. This study is focused on luminescent carbon dots derived from o-phenylenediamine and gadolinium chloride or nitrate hexahydrate. Aim of study. The study aims to fabricate long-wavelength photoluminescent gadolinium-doped carbon dots that could function as contrast agents for magnetic resonance imaging. Additionally, the study investigates the impact of the precursor type used on the chemical composition and optical transitions of the resulting nanoparticles. Method. Carbon dots were synthesized using a one-step solvothermal method, and their composition and optical properties were analyzed using spectroscopy methods. Magnetic resonance imaging was conducted using a clinical magnetic resonance imaging scanner with a field strength of 1.5 T. Main results. In this study, two types of carbon dots were synthesized from o-phenylenediamine and gadolinium chloride or nitrate hexahydrate using the solvothermal method. Metal doping, at a concentration sufficient for further investigations, is achieved only when gadolinium chloride is used. Additionally, the presence of gadolinium chloride during the synthesis leads to the formation of luminescent centers within the carbon dots with emission at 600–720 nm and a photoluminescence quantum yield of 6.3%. In contrast, gadolinium nitrate increases the nitrogen content within the o-phenylenediamine-based carbon dots while inhibiting metal doping. The luminescent band with an emission maximum at 550 nm and a photoluminescence quantum yield of 7.4% originates from the o-phenylenediamine derivatives formed within such carbon dots. The study results also show that the gadolinium-doped carbon dots alter the relaxation times during magnetic resonance scanning, and the calculated relaxivity (r1 and r2) values are 6.4 and 38.6L⋅mmol−1⋅s−1, respectively. Thus, the synthesized carbon dots function as positive contrast agents during magnetic resonance scanning. Practical significance. Carbon dots with long-wavelength emission are promising nanoprobes for luminescence imaging. With gadolinium doping, these nanoparticles can also be used as contrast agents during magnetic resonance imaging. Consequently, carbon dots based on o-phenylenediamine and gadolinium chloride hexahydrate can be further utilized as dual-mode nanoprobes for bioimaging.
Optical properties of InGaP(As) quantum dots in GaAs/AlGaAs/InGaP/InGaAs heterostructures
Authors: Andryushkin Vladislav V. , Novikov Innokenty I. , Gladyshev Andrey G. , Babichev Andrey V. , Nevedomsky Vladimir N. , Papylev Denis S. , Kolodeznyi Evgenii S. , Karachinsky Leonid Ya. , Egorov Anton Yu. 
Published: November 2024

Subject of study. InGaP(As) quantum dots in GaAs/AlGaAs/InGaP/InGaAs heterostructures were studied. Aim of study. The aim was to establish the correlation between the maximum photoluminescence wavelength of InGaP(As) semiconductor quantum dots and the location of InGaAs quantum wells within GaAs/AlGaAs/InGaP/InGaAs heterostructures. Method. InGaP(As) quantum dots were synthesized by molecular-beam epitaxy; phosphorus was replaced with arsenic in a thin InGaP layer during the epitaxial growth. The optical properties of these InGaP(As) quantum dots were investigated using photoluminescence spectroscopy. Main results. The results show that using an InGaAs quantum well and the formation surface for the InGaP layer, which is subsequently transformed into quantum dots, does not affect the maximum photoluminescence wavelength of the quantum dots. However, the photoluminescence peaks under a long-wave shift of 56 nm when the quantum dots are overgrown with a 5-nm-thick InGaAs quantum well with an InAs molar fraction of 0.17. The measured surface density of the quantum dots is 1.3×1012cm−2. Practical significance. The results obtained from the analysis of the optical properties of the synthesized InGaP(As) quantum dots will serve as a foundation for the fabrication of active regions for near-infrared light sources.
Effect of changing the growth mechanism on the synthesis of two-dimensional germanium layers and quantum dots on silicon
Authors: Kukenov Olzhas I. , Dirko Vladimir V. , Sokolov Arseniy S. , Lozovoy Kirill A. , Shvaleva Kristina I. , Kokhanenko Andrey P. , Voitsekhovskii Alexander V. 
Published: November 2024

Subject of study. The work studied the formation of germanium quantum dots on silicon with (100) crystallographic orientation under different growth regimes. Aim of study. The work is devoted to conducting experimental studies of the influence of growth mechanisms on the formation of germanium layers and quantum dots on a silicon (100) substrate for the production of optical elements based on silicon-germanium nanostructures. Methods. After pre-epitaxial cleaning of the Si substrate, germanium is synthesized on Si(100) through molecular beam epitaxy. The surface morphology is analyzed using reflection high-energy electron diffraction during synthesis and scanning electron microscopy after deposition. Main results. The work determines the temperature ranges at which the Si/Si(100) growth occurs due to the nucleation of islands, due to the movement of steps, and in combination. The effect of changing growth mechanisms on the size and density of Ge quantum dots on Si(100) is shown. Practical significance. The research results provide insight into the influence of growth mechanisms on the sizes of formed germanium quantum dots on silicon, which will make it possible to create nanophotonics and nanoelectronics elements with strictly specified parameters.
Impact of remote social interaction during the COVID-19 pandemic on the cognitive and psychological status of older adults with and without cognitive impairment: A randomized controlled study
Authors: Vives-Rodriguez Ana L. , Marin Anna , Schiloski Kylie A. , Hajos Gabor P. , Di Crosta Adolfo , Ceccato Irene , La Malva Pasquale , Anderson Diana C. , Lahdo Naheer , Donnelly Kaleigh , Dong Jiali , Kasha Sabrina , Rooney Colleen , Dayaw Judith , Marton Gabrielle , Wack Audrey , Hanger Vanessa , DeCaro Renée , Di Domenico Alberto , Turk Katherine W. , Palumbo Rocco , Budson Andrew E. 
Published: November 2024

Background
Social isolation and loneliness have both been associated with psychological health and cognitive decline in older adults. This study investigated the impact of social interaction through remote communication technologies during the COVID-19 pandemic on the cognitive and psychological status of older adults with and without cognitive impairment.

Methods
Participants were recruited from Boston (USA) and Chieti (Italy). The study used a randomized single-blinded controlled crossover design with an intervention (remote social conversations with research staff over 20-minute video or telephone calls three times per week) and a passive control condition, each one of 4-weeks duration. The primary outcome was a composite cognitive score change from baseline to week 4. Secondary outcomes included scales for mood, anxiety, and loneliness.

Results
Out of 196 participants recruited from April 2020 to April 2021, 17% dropped out. Based on the blind MoCA, 52% had cognitive impairment, and 25% were at risk of social isolation according to the Lubben social network scale. We observed that larger social networks were linked to better cognitive status and lower depression and anxiety levels, while loneliness was directly associated to depression severity. Older adults with cognitive impairment exhibited higher levels of depression and anxiety and were at greater risk for social isolation. In terms of the intervention, 91% preferred telephone over video calls. The intervention did not lead to improvements in cognitive or psychological scores.

Conclusions
More work is needed to assess the utility of this intervention for the support of a heterogenous cross-cultural sample of older adults at-risk for social isolation, including individuals with cognitive impairment. Future research should explore longer intervention periods, categorize participants by call type, and target those meeting social isolation criteria.

Trial registration
ClinicalTrials.gov NCT04480112.
Enhancing daily oral PrEP adherence with digital communications: Protocol for a systematic review and meta-analysis
Authors: Brisson Julien , Castro-Arteaga Mariangela , Apedaile Dorothy , Perez-Brumer Amaya 
Published: November 2024

Introduction
Pre-exposure prophylaxis (PrEP) stands as an effective tool in preventing HIV transmission among individuals at risk of HIV infection. However, the effectiveness of daily oral PrEP is contingent on the adherence of its users, which can pose a challenge for many individuals. Various studies have explored different interventions aimed at bolstering PrEP adherence. One recurring type of intervention revolves around digital communication (e.g., SMS, mobile applications) to send reminders for PrEP usage. The objective of our systematic review and meta-analysis is to address the following research question: What is the effectiveness of digital communication interventions in enhancing daily oral PrEP adherence among individuals at a heightened risk of HIV infection? This paper presents our study protocol.

Method and analysis
We will conduct searches across four health-related databases: Embase, PubMed, Web of Science, and PsycINFO. We will also explore other sources, including clinical trials registries and grey literature. Our search will be restricted to original randomized controlled trials published in English, French, and Spanish conducted since 2012, when PrEP was approved, to today. To ensure rigor, three reviewers will perform the systematic review and meta-analysis. This systematic review will adhere to the guidelines outlined in the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Our primary outcome of interest is proper daily oral PrEP adherence, which we will measure using association metrics (e.g., odds ratios).

Discussion
This review will offer insights into the effectiveness of utilizing digital communication methods to assist individuals at risk of HIV in improving their PrEP adherence.

Protocol registration number
International Prospective Register for Systematic Reviews (PROSPERO) number CRD42023471269.
Recognising and responding to the community needs of gay and bisexual men around mpox
Authors: Gilmore John , Comer David , Field David J. , Parlour Randal , Shanley Adam , Noone Chris 
Published: November 2024

Background
In May 2022, a global surge in mpox cases, typically endemic to Western and Central Africa, particularly affected gay, bisexual, and other men who have sex with men (gbMSM). This study examines gbMSM communities’ experiences and perceptions around Ireland’s public health response to the outbreak.

Methods
A cross-sectional mixed-methods online survey was conducted. Qualitative data were analysed using reflexive thematic analysis informed by critical realism.

Findings
A total of 163 gay and bisexual men took part in the survey. Participants accessed information from diverse sources, reporting varying levels of trustworthiness. Overall, participants were well-informed. Four themes were developed from the qualitative data: (1) Perceptions of the mpox response: divergence in urgency, priority, and care; (2) The mpox outbreak as a sign of otherness for gbMSM; (3) The potential for othering through mpox prevention practices; and (4) mpox, memory and fear.

Discussion
While community-led initiatives were effective, significant challenges included stigmatisation, discrimination, and mistrust towards public health institutions, influenced by institutionalised homophobia. The study underscores the need for inclusive, culturally sensitive, and transparent public health strategies.

Conclusion
The mpox outbreak highlights the importance of robust community collaboration in public health interventions. Future strategies must ensure equitable access to information, vaccination, and care, and address broader structural inequalities to foster trust and engagement within affected communities.
An experimental study on the diagnostic advantage of dual-energy computed tomography over single-energy scan to evaluate the treatment effect following transcatheter arterial chemoembolization
Authors: Yamane Aya , Yasui Daisuke , Itoh Hiroshi , Kobayashi Masayuki , Kumita Shin-Ichiro 
Published: November 2024

Objectives
We assessed the diagnostic advantage of dual-energy computed tomography (DECT) over single-energy computed tomography (SECT) to evaluate lipiodol accumulation in target lesions following transcatheter arterial chemoembolization (TACE).

Methods
TACE was performed in 10 rabbits in whom the VX2 tumor was implanted in their left liver lobes. The miriplatin-lipiodol mixture was injected into the common hepatic artery. All rabbits were sacrificed 2 days after TACE, and the liver was harvested. CT was performed using both single-energy and dual-energy scan modes. The specimen was stained with Oil Red O to evaluate lipiodol accumulation; this was considered the reference standard. Mutual information (MI) was used to evaluate the significance of radiological-pathological correlation. Estimated iodine content values on iodine material density images were compared with actual values obtained using mass spectroscopy.

Results
Mean MI values were 0.69, 0.32, 0.83, 0.72, 0.65, and 0.58 for single-energy scan; iodine density images; and virtual monoenergetic images for energy levels of 40, 60, 80, and 100 keV, respectively. The MI value of the monochromatic image (40 keV) was the highest among all sequences. However, this was not significant compared with the single-energy scan (p = 0.81). A significant correlation was observed between the estimated and actual values of iodine content (Pearson’s product moment coefficient = 0.70, p = 0.023).

Conclusion
More accurate and quantitative lipiodol evaluation in targeted tumors after TACE can be achieved by applying DECT rather than SECT.