bluuebunny/crossref_metadata_2025_split huggingface dataset:
H∞ finite‐horizon filtering for complex networks with state saturations: The weighted try‐once‐discard protocol
Authors: Wang Dong , Wang Zidong , Shen Bo , Li Qi 
Published: February 2019

SummaryThis paper addresses the finite‐horizon H∞ filtering problem for a kind of discrete state‐saturated time‐varying complex networks subjected to the weighted try‐once‐discard (WTOD) protocol. Under the WTOD protocol, only the measurement signal from one sensor node is allowed to be transmitted to the filter at each time point, where such a node is selected based on a certain quadratic selection principle. The main purpose of this paper is to design an H∞ filter that guarantees the disturbance attenuation level on a given finite time‐horizon for the underlying complex network subject to both state saturations and WTOD protocols. By using the convex hull approach, sufficient conditions are first obtained to ensure the existence for the desired filter to achieve the H∞ performance specification by means of a few recursive matrix inequalities. Then, based on the obtained results, the filter parameters are designed, which cope effectively with both state saturations and communication protocols. Finally, a numerical simulation is employed to demonstrate the validity of the developed filter algorithm.
NASA's alphasat propagation terminals: Milan, Italy, and Edinburgh, Scotland
Authors: Zemba M. , Nessel J. , Riva C. , Luini L. , Goussetis G. 
Published: February 2019

SummarySince May of 2014, NASA's Glenn Research Center has operated measurement campaigns for the Alphasat Aldo Paraboni Propagation Experiment alongside the European community of propagation experimenters. Presently, three NASA stations have been deployed to distinct climatological regions across Europe. NASA's participation in the campaign began in 2014 through a collaborative effort with the Politecnico di Milano (POLIMI) to jointly operate a 20/40 GHz ground terminal at the POLIMI campus in Milan, Italy. Subsequently, a single‐channel 40 GHz terminal was deployed to Edinburgh, Scotland in March 2016 in collaboration with Heriot‐Watt University (HWU). A third terminal was deployed to NASA's Madrid Deep Space Communications Complex (MDSCC) in March 2017 with NASA'S Jet Propulsion Laboratory (JPL), also observing the 40 GHz beacon. In addition, a fourth station is planned for deployment to Andøya, Norway by early 2019 in collaboration with the Norwegian Defence Research Establishment (FFI). This paper will detail the design and results of the two most established terminals, Milan and Edinburgh, which together comprise 11 station years of propagation measurements.
Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats
Authors: Narbute Karīna , Piļipenko Vladimirs , Pupure Jolanta , Dzirkale Zane , Jonavičė Ugnė , Tunaitis Virginijus , Kriaučiūnaitė Karolina , Jarmalavičiūtė Akvilė , Jansone Baiba , Kluša Vija , Pivoriūnas Augustas 
Published: February 2019

Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting millions of people worldwide. At present, there is no effective cure for PD; treatments are symptomatic and do not halt progression of neurodegeneration. Extracellular vesicles (EVs) can cross the blood–brain barrier and represent promising alternative to the classical treatment strategies. In the present study, we examined therapeutic effects of intranasal administration of EVs derived from human exfoliated deciduous teeth stem cells (SHEDs) on unilateral 6-hydroxydopamine (6-OHDA) medial forebrain bundle (MFB) rat model of PD. CatWalk gait tests revealed that EVs effectively suppressed 6-OHDA-induced gait impairments. All tested gait parameters (stand, stride length, step cycle, and duty cycle) were significantly improved in EV-treated animals when compared with 6-OHDA-lesion group rats. Furthermore, EVs slowed down numbers of 6-OHDA-induced contralateral rotations in apomorphine test. Improvements in motor function correlated with normalization of tyrosine hydroxylase expression in the striatum and substantia nigra. In conclusion, we demonstrated, for the first time, the therapeutic efficacy of intranasal administration of EVs derived from SHEDs in a rat model of PD induced by 6-OHDA intra-MFB lesion. Our findings could be potentially exploited for the development of new treatment strategies against PD.
Dual Functional Modification of Alkaline Amino Acids Induces the Self‐Assembly of Cylinder‐Like Tobacco Mosaic Virus Coat Proteins into Gear‐Like Architectures
Authors: Zhang Jian‐Ting , Kankala Ranjith Kumar , Zhou Yi‐Hao , Dong Jin‐Chen , Chen Ai‐Zheng , Wang Qiangbin 
Published: February 2019

AbstractHerein, the assembly of 3D uniform gear‐like architectures is demonstrated with a tobacco mosaic virus (TMV) disk as a building block. In this context, the intrinsic behavior of the TMV disk that promotes its assembly into nanotubes is altered by a synergistic effect of dual functional modifications at the 53rd arginine mutation and the introduction of lysine groups in the periphery at 1st and 158th positions of the TMV disk, which results in the formation of 3D gear‐like superstructures. Therein, the 53rd arginine moiety significantly strengthens the linkage between TMV disks in the alkaline environment through hydrogen bond interactions. The charge of lysine‐modified lateral surfaces is partially neutralized in the alkaline solution, which induces the TMV disk to form a gear‐like architecture to maintain its structural stability by exploiting the electrostatic repulsion between neighboring TMV disks. This study not only provides explicit evidence regarding the molecular‐level understanding of how the modification of site‐specific amino acid affects the assembly of resultant superstructures but also encourages the fabrication of functional protein‐based nanoarchitectures.
Disorders of renal NaCl transport and implications for blood pressure regulation
Authors: Hennings J. Christopher , Hübner Christian A. 
Published: February 2019

AbstractHypertension is one of the major risk factors for cardiovascular disease in industrialized societies. Substantial progress has been made in understanding its epidemiology, its pathophysiology, and its associated risks such as coronary artery disease, stroke, and heart failure. Because there is consensus that the abnormal retention of sodium by the kidney is a major important pathophysiological event in hypertension, this review focuses on mechanisms of renal NaCl transport and associated genetic disorders.
Humanism
Authors: SETIYA KIERAN 
Published: February 2019

ABSTRACTI defend a form of humanism on which we have reason to care about human beings that we do not have to care about other animals, and human beings have rights against us that other animals lack. Humanism respects the equal worth of those born with severe congenital cognitive disabilities. I address the charge of speciesism and explain how being human is an ethically relevant fact.
Profiles of Human Enteroviruses Associated with Hand, Foot, and Mouth Disease in Nanjing, China
Authors: Chen Qian , Zhang Qihua , Hu Zheng 
Published: February 2019

ABSTRACTObjectiveHand, foot, and mouth disease (HFMD) is a common infectious disease caused by a group of viruses. The causative viruses have changed over time, and there is a need for a more effective protective vaccine. In this study, we investigated the profiles of human enteroviruses that caused HFMD outbreaks in Nanjing in 2015, with the goal of guiding the future prevention and treatment of HFMD.MethodsSpecimens were collected from 1097 patients admitted to our hospital and diagnosed with HFMD. Enteroviruses in the specimens were identified by real-time polymerase chain reaction and epidemiological patterns were analyzed with the clinical data.ResultsAmong the 1097 clinically diagnosed HFMD cases, 916 cases were confirmed by laboratory tests. The results showed that the main infectious virus was coxsackievirus A6 (CVA6) (41.75%), followed by enterovirus 71 (EV71) (27.48%), coxsackievirus A16 (7.43%), coxsackievirus A10 (6.84%), and others (16.51%). Further investigation indicated that CVA6 caused mild cases of HFMD, while EV71 caused severe cases. More enterovirus positive cases were reported from rural areas than from urban areas.ConclusionsCA6 and EV71 were the chief pathogenic viruses of HFMD cases in the present study. Schools, childcare centers, and families from rural areas should be the major targets for prevention and awareness of HFMD. This study will provide information useful in the prevention and management of HFMD and the development of relevant vaccines for HFMD in the future. (Disaster Med Public Health Preparedness. 2019;13:740–744).
The acoustic impedance of a laminar viscous jet through a thin circular aperture
Authors: Fabre David , Longobardi Raffaele , Bonnefis Paul , Luchini Paolo 
Published: February 2019

The unsteady axisymmetric flow through a circular aperture in a thin plate subjected to harmonic forcing (for instance under the effect of an incident acoustic wave) is a classical problem first considered by Howe (Proc. R. Soc. Lond. A, vol. 366, 1979, pp. 205–223), using an inviscid model. The purpose of this work is to reconsider this problem through a numerical resolution of the incompressible linearized Navier–Stokes equations (LNSE) in the laminar regime, corresponding to $Re=[500,5000]$. We first compute a steady base flow which allows us to describe the vena contracta phenomenon in agreement with experiments. We then solve a linear problem allowing us to characterize both the spatial amplification of the perturbations and the impedance (or equivalently the Rayleigh conductivity), which is a key quantity to investigate the response of the jet to acoustic forcing. Since the linear perturbation is characterized by a strong spatial amplification, the numerical resolution requires the use of a complex mapping of the axial coordinate in order to enlarge the range of Reynolds number investigated. The results show that the impedances computed with $Re\gtrsim 1500$ collapse onto a single curve, indicating that a large Reynolds number asymptotic regime is effectively reached. However, expressing the results in terms of conductivity leads to substantial deviation with respect to Howe’s model. Finally, we investigate the case of finite-amplitude perturbations through direct numerical simulations (DNS). We show that the impedance predicted by the linear approach remains valid for amplitudes up to order $10^{-1}$, despite the fact that the spatial evolution of the perturbations in the jet is strongly nonlinear.
An optimal improvement for the Hardy inequality on the hyperbolic space and related manifolds
Authors: Berchio Elvise , Ganguly Debdip , Grillo Gabriele , Pinchover Yehuda 
Published: February 2019

AbstractWe prove optimal improvements of the Hardy inequality on the hyperbolic space. Here, optimal means that the resulting operator is critical in the sense of Devyver, Fraas, and Pinchover (2014), namely the associated inequality cannot be further improved. Such inequalities arise from more general, optimal ones valid for the operator $ P_{\lambda }:= -\Delta _{{\open H}^{N}} - \lambda $ where 0 ⩽ λ ⩽ λ1(ℍN) and λ1(ℍN) is the bottom of the L2 spectrum of $-\Delta _{{\open H}^{N}} $, a problem that had been studied in Berchio, Ganguly, and Grillo (2017) only for the operator $P_{\lambda _{1}({\open H}^{N})}$. A different, critical and new inequality on ℍN, locally of Hardy type is also shown. Such results have in fact greater generality since they are proved on general Cartan-Hadamard manifolds under curvature assumptions, possibly depending on the point. Existence/nonexistence of extremals for the related Hardy-Poincaré inequalities are also proved using concentration-compactness technique and a Liouville comparison theorem. As applications of our inequalities, we obtain an improved Rellich inequality and we derive a quantitative version of Heisenberg-Pauli-Weyl uncertainty principle for the operator $P_\lambda.$
Type Synthesis of Multi-Loop Spatial Mechanisms With Three Translational Output Parameters Based on Virtual-Loop Theory and Assur Groups
Authors: Zhang Xing , Mu Dejun , Zhang Yitong , You Henghao , Wang Hongrui 
Published: February 2019

SummaryThis paper presents a new approach to synthesize multi-loop mechanisms with three translational displacement parameters based on virtual-loop theory and Assur groups. The approach used kinematic links as a generalized link group added one-by-one to the output link, which further extends the unified link groups in the plane and space. Firstly, the concept of infinitesimal displacement parameters is introduced to describe the displacement parameters. The dependence on the change in the degree of freedom (DOF) and displacement parameters of the output link after adding a 0-DOF generalized link group is established. Then, the link groups with three displacement parameters are synthesized, and the intersection operation rules are given. The single-loop mechanism is synthesized under two circumstances. The 1-, 2-, and 3-DOF dual-loop mechanisms are obtained by adding corresponding generalized link groups. Finally, the multi-loop mechanisms are obtained by adding corresponding generalized link groups. Some novel mechanisms are synthesized to illustrate the effectiveness of the proposed approach.
Transcriptional regulatory activity of the cereal grain bZip protein TaABF1 can be either stimulated or inhibited by phosphorylation
Authors: Smith Alison E. , Yang Xi , Lutian Justin , Chelimo David , Lopez Juvenal , Uwase Grace , Johnson Russell R. 
Published: February 2019

AbstractThe wheat bZip transcription factor TaABF1 mediates both abscisic acid (ABA)-induced and ABA-suppressed gene expression. As levels of TaABF1 protein do not change in response to ABA, and TaABF1 is in a phosphorylated statein vivo, we investigated whether TaABF1 could be regulated at the post-translational level. In bombarded aleurone cells, a TaABF1 protein carrying phosphomimetic mutations (serine to aspartate) at four sites (S36D, S37D, S113D, S115D) was three to five times more potent than wild-type TaABF1 in activatingHVA1, an ABA-responsive gene. The phosphomimetic mutations also increased the ability of TaABF1 to downregulate the ABA-suppressed geneAmy32b. These findings strongly suggest that phosphorylation at these sites increases the transcriptional regulatory activity of TaABF1. In contrast to the activation observed by the quadruple serine to aspartate mutation, a single S113D mutation completely eliminated the ability of TaABF1 to upregulateHVA1or downregulateAmy32b. Thus phosphorylation of TaABF1 can either stimulate or inhibit the activity of TaABF1 in regulating downstream genes, depending on the site and pattern of phosphorylation. Mutation of S318 and S322 (in the bZIP domain) eliminated the ability of TaABF1 to activateHVA1, but had no effect on the ability of TaABF1 to downregulateAmy32b, suggesting that TaABF1 repressesAmy32bexpression through a mechanism other than direct DNA binding. An important step towards understanding how ABA and gibberellin (GA) signals are integrated through TaABF1 phosphorylation to regulate downstream gene expression is to clarify the effects of those hormones on the expression of specific genes. In contrast to some other ABA-induced genes, we found thatHVA1induction by ABA or TaABF1 is not inhibited by GA.
Can Kant’s Formula of the End in Itself Condemn Capitalism?
Authors: Furner James 
Published: February 2019

AbstractKantian socialists at the turn of the twentieth century, as well as contemporary authors seeking a principle with which to condemn capitalism, have turned to Kant’s Formula of the End in Itself (FEI). This article assesses the arguments from FEI against capitalism from the perspective of the issues that arise in interpreting and applying Kant’s formula. There are various strategies with which a Kantian might use FEI to condemn conduct that Kant did not use FEI to condemn. The article asks whether any of the existing arguments from FEI employ plausible versions of these strategies to derive a strict duty from that formula’s Never Merely as a Means principle that condemns capitalism.
The Library in an Agile World: Case Studies from Gowling WLG and Withers LLP
Authors: Green Timonie , Miller Diane 
Published: February 2019

AbstractThis article developed from a talk delivered by the authors, Timonie Green and Diane Miller, at the BIALL Annual Conference in June 2018, whereby they looked at how the Library and Information Services in both of their firms have managed a move to agile working. Withers, at the time, were deep in preparations for the move, whilst Gowling WLG had been working agilely for some time. The hope is that by telling these stories, and talking about the issues encountered, some pointers and ideas can be given to other firms facing the challenge.
Coeval Early Ediacaran Breakup of Amazonia, Baltica, and Laurentia: Evidence From Micro‐Baddeleyite Dating of Dykes From the Novillo Canyon, Mexico
Authors: Weber Bodo , Schmitt Axel K. , Cisneros de León Alejandro , González‐Guzmán Reneé 
Published: February 2019

AbstractFinal Rodinia supercontinent breakup during the early Ediacaran is recorded by mafic dyke swarms in Baltica and Laurentia, but corresponding dykes have been elusive for Amazonia, the third craton involved. We report ages and compositions for plume‐related dykes intruded into Rodinia‐type basement of the Novillo Gneiss, part of a microcontinent placed between Amazonia and Baltica in Rodinia reconstructions. In situ U‐Pb micro‐baddeleyite dating with secondary ion mass spectrometry yielded dyke intrusion ages of 619 ± 9 Ma (95% c.i.), coeval with ages of similar dykes from Baltica and Laurentia. A younger age group is consistent with an earlier 40Ar‐39Ar age at ~545 Ma, reflecting Pb loss and recrystallization during hydrothermal alteration. The results indicate an Amazonia‐Baltica‐Laurentia connection prior to opening of the Iapetus Ocean and suggest a previously unrecognized superplume‐related large igneous province extending over all sides of the former triple point. Weathering of these large igneous province basalts may have contributed to Ediacaran Gaskiers glaciation.
Topographic Controls on the Extension and Retraction of Flowing Streams
Authors: Prancevic Jeff P. , Kirchner James W. 
Published: February 2019

AbstractFlowing stream networks extend and retract as their surrounding landscapes wet up and dry out, both seasonally and during rainstorms, with implications for aquatic ecosystems and greenhouse gas exchange. Some networks are much more dynamic than others, however, and the reasons for this difference are unknown. Here we show that the tendency of stream networks to extend and retract can be predicted from down‐valley changes in topographic attributes (slope, curvature, and contributing drainage area), without measuring subsurface hydrologic properties. Topography determines where water accumulates within valley networks, and we propose that it also modulates flow partitioning between the surface and subsurface. Measurements from 17 mountain stream networks support this hypothesis, showing that undissected valley heads have greater subsurface transport capacities than sharply incised valleys downstream. In catchments where broad valley heads rapidly transition to sharply incised valleys, subsurface transport capacity decreases abruptly, stabilizing stream length through wet and dry periods.
Moho Depth Variations From Receiver Function Imaging in the Northeastern North China Craton and Its Tectonic Implications
Authors: Zhang Ping , Yao Huajian , Chen Ling , Fang Lihua , Wu Yan , Feng Jikun 
Published: February 2019

AbstractA detailed knowledge of the crustal thickness in the northeastern North China Craton (NCC) is important for understanding the unusual Phanerozoic destruction of the craton. We achieve this goal by employing a 2‐D wave equation‐based migration method to P receiver functions from 198 broadband seismic stations, using Ps conversions and surface‐reflected multiples. By combining receiver function images along 19 profiles, we constructed a high‐resolution Moho depth model for the northeastern NCC. The results present dominant E‐W Moho depth variations similar to previous observations and new regional N‐S variations beneath both sides of the North‐South Gravity Lineament. To the west, while a deeper Moho (∼42 km) appears in the interior of the Trans‐North China Orogen, a relatively shallow Moho (∼38 km) exists in the northern margin of the Trans‐North China Orogen to western NCC. To the east, the crust beneath the Yan Mountains in the marginal area is thicker (∼32–40 km) than that (∼26–32 km) beneath the Bohai Bay Basin in the craton interior, and the Moho further shallows from NE (∼32 km) to SW (∼26 km) within the basin. Along with other observations, we conclude that the dominant E‐W difference may have been associated with the Paleo‐Pacific plate subduction under eastern Asia since the Mesozoic. The newly observed complex N‐S variations may have reflected the structural heterogeneity of the cratonic lithosphere inherited since the formation of the NCC in the Paleoproterozoic, or spatially uneven effects on the cratonic lithosphere of subsequent thermotectonic events during the long‐term evolution of the craton, or both.
Understanding Neogene Oxygen Isotopes in the Southern Great Plains Using Isotope‐Enabled General Circulation Model Simulations
Authors: Lee Jung‐Eun 
Published: February 2019

AbstractThe expansion of C4 grassland in the Neogene, starting from 4 to 9 million years ago, is thought to be caused by decreasing CO2 concentration, increasing aridity, or a combination of both. Oxygen isotopes from paleoproxies show a decreasing trend and an increasing variability from mid‐Miocene to Pleistocene in the Southern Great Plains of the United States, where carbon isotopes indicate an overall increase of C4 plants during the same time period. Using isotope‐enabled General Circulation Model (GCM) simulations, here I explore the causes of the long‐term trend and variability of oxygen isotopes, ultimately to understand the climatic condition that is associated with the C4 grassland expansion. Climate model simulations were performed varying the orbital configuration, CO2 concentration, and vegetation coverage. Model results show that the isotopic composition of winter precipitation varies more than that of summer precipitation and depends strongly on temperature, or more precisely on the contribution of snow to total precipitation. I conclude that the long‐term isotopic composition of precipitation decreases because of gradual cooling and varies more because of lower and more variable cold season temperature in a colder climate in response to fluctuating orbital configuration. This study implies that C4 grassland in the Southern Great Plains region expanded along with global cooling, possibly resulting from the decreasing atmospheric CO2 concentration.