bluuebunny/crossref_metadata_2025_split huggingface dataset:
Touch imprint cytology on endoscopic ultrasound fine‐needle biopsy provides comparable sample quality and diagnostic yield to standard endoscopic ultrasound fine‐needle aspiration specimens in the evaluation of solid pancreatic lesions
Authors: Crinò Stefano Francesco , Larghi Alberto , Bernardoni Laura , Parisi Alice , Frulloni Luca , Gabbrielli Armando , Parcesepe Pietro , Scarpa Aldo , Manfrin Erminia 
Published: November 2018

ObjectivesEndoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) is the gold standard for the diagnosis of solid pancreatic lesions (SPLs). Cytological samples can also be obtained using touch imprint cytology (TIC) on EUS fine‐needle biopsy (FNB) specimens. We aimed to compare sample quality and diagnostic yield of EUS‐FNA‐standard cytology (EUS‐FNA‐SC) to that of EUS‐FNB‐TIC in a series of patients with SPLs.MethodsThirty‐two consecutive patients referred for EUS‐tissue acquisition of SPLs who underwent rapid on‐site evaluation of both EUS‐FNA‐SC and paired EUS‐FNB‐TIC during the same endoscopic session were retrospectively identified. Sample quality (evaluated in terms of blood contamination, presence of clots, tissue casts, cellularity, and necrosis) and diagnostic yield were compared between the techniques.ResultsThe mean number of passes to reach diagnosis at rapid on‐site evaluation was similar between EUS‐FNA‐SC and EUS‐FNB‐TIC (1.09 ± 0.3 vs 1.13 ± 0.34, P = .711). EUS‐FNA‐SC scores of sample quality were comparable to those of EUS‐FNB‐TIC (blood contamination, 2.47 ± 1.11 vs 2.25 ± 1.14, P = .109; clots, 1.25 ± 0.76 vs 1.19 ± 0.69, P = .624; tissue casts, 3.56 ± 0.88 vs 3.59 ± 1.09, P = .872; cellularity, 2.84 ± 1.11 vs 3.09 ± 1.09, P = .244; necrosis, 2.25 ± 1.08 vs 2.53 ± 1.02 P = .059; total score, 12.38 ± 2.88 vs 17.66 ± 2.38, P = .536). Adequacy, sensitivity and diagnostic accuracy of the two sampling techniques were equal (93.7%, 90.6% and 90.6%, respectively).ConclusionsEUS‐FNB‐TIC provides comparable samples to those of EUS‐FNA‐SC and combines the benefits of cytology and histology for the evaluation of SPLs by employing a single needle during the same endoscopic procedure.
Factors that hindered care seeking among people with a first diagnosis of psychosis
Authors: Yarborough Bobbi J. , Yarborough Micah T. , Cavese Julie C. 
Published: November 2018

AimEvidence‐based treatment can improve psychosis outcomes, but service providers need to understand and address the reasons people experiencing first episode psychosis avoid or delay care seeking. The goal of this study was to identify reasons care seeking might be postponed, from the points of view of patients, caregivers and health care professionals in a large health care delivery system, in the United States, without an early psychosis intervention program.MethodsAbout 22 patients who had received an initial psychosis diagnosis and 10 of their caregivers were interviewed about their experiences and pathways to care. Additionally, 15 administrator or clinician key informants with responsibility for psychosis services were interviewed and asked to describe ways that they thought early psychosis identification and treatment engagement could be improved. All interviews were transcribed, coded and analysed together using thematic analysis.ResultsSome patients did not perceive their early psychotic experiences as concerning because they were familiar. Among those concerned, the desire to make sense of their experiences and avoid detection or stigma caused some to conceal symptoms or isolate themselves. Caregivers who observed withdrawal often attributed it to typical adolescent behaviour, which led to treatment delays. Legal and privacy protections led to delays among young adults.ConclusionsTo attract individuals to early psychosis services, outreach and engagement programs should help individuals and caregivers recognize their experiences as opportunities for care, and design and market services that promote sense‐making, offer hope and reduce stigma and system‐level privacy‐related barriers to care engagement.
Objective and subjective cognitive functioning in relation to psychopathology among women with early psychosis
Authors: Tong Alan C.Y. , Chang Wing Chung , Chan Angel N.Y. , Lin Jessie J. 
Published: November 2018

BackgroundSubjective cognitive impairment (SCI) among early psychosis is under‐recognized and under‐studied. However, SCI is as important as objective impairment to be understood, since it assesses cognitive difficulties in real‐life situations from a personal perspective and is therefore an essence of individualized medicine. This study aims to explore the associations between the objective and subjective measures of cognitive impairments and to identify factors contributing to SCI among people with early psychosis.MethodsParticipants were 60 females (mean age 24.57 ± 8.28) who had a diagnosis of psychotic‐spectrum disorder within 5 years. They completed a battery of neuropsychological tests assessing a range of cognitive functions including verbal learning, memory, attention, and executive functions. The Subjective Cognitive Impairment Scale (SCIS) was used to assess their perceived cognitive decline. Psychotic symptoms and depression were also assessed.ResultsSCIS was not correlated with any of the objective cognitive tests results. It was positively correlated with depression and positive symptoms. A hierarchical multiple regression model revealed that positive symptoms and depression together explained 31.9% of the total variance in SCIS and only depression significantly predicted SCI. Performances on the memory tests were correlated with, and predicted by negative symptoms.ConclusionsThere was no correlation between SCI and objective cognitive performances in patients with early psychosis. Treatments should not only focus on symptomatic remission and performance of cognitive tests, but also place emphasis on improving moods and subjective cognitive functions of individuals with early psychosis.
Psychiatrists' opinion towards medication discontinuation in remitted first‐episode psychosis: A multi‐site study of the Asian Network for Early Psychosis
Authors: Hui Christy L.‐M. , Wong Andreas K.‐H. , Leung Whitty W.‐T. , Lee Edwin H.‐M. , Chan Sherry K.‐W. , Chang Wing‐Chung , Chen Eric Y.‐H. , Chan Tommy C.‐T. , Swapna Verma , Tagata Hiromi , Tsujino Naohisa , Nemoto Takahiro , Mizuno Masafumi , Kang Nam‐In , Kim Sung‐Wan , Chung Young‐Chul 
Published: November 2018

AimThe study investigated psychiatrists' views towards the issue of medication discontinuation for patients in remission from first‐episode psychosis in four countries (Hong Kong, Korea, Singapore and Japan) that are part of the Asian Network for Early Psychosis, focusing on whether the views of these countries differ with one another.MethodsA questionnaire was distributed to psychiatrists for completion. The questionnaire contained three sections: direct questions probing at views on medication discontinuation, case vignettes to assess applied decision‐making and a checklist of criteria psychiatrists may view as necessary for the patient to satisfy before discontinuation. Total of 484 psychiatrists (97 from Hong Kong, 88 from Korea, 64 from Singapore and 233 from Japan) completed the questionnaire.ResultsWe found that (a) Asian psychiatrists believed that 1% to 19% of remitted patients can discontinue medication, an estimation that was lower than Western psychiatrists; (b) in agreement with clinical guidelines, Asian psychiatrists believed that patients should remain on medication for at least 1 to 2 years following the absence of psychotic symptoms; (c) “Absence of any relapsing episode following first episode” was considered the most important criterion when making a decision; and (d) there were significant differences in clinicians' perceptions across the four countries: for instance, Korean psychiatrists were more conservative with the duration of antipsychotics maintenance, while Singaporean psychiatrists were more open‐minded towards clinical trials.ConclusionsCulture and social norms appear to determine the relative importance of factors that psychiatrists might consider during the decision‐making process, thereby producing variations in the views held in different countries.
Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses
Authors: Gozalo‐Marcilla M. , de Oliveira A. R. , Fonseca M. W. , Possebon F. S. , Pelligand L. , Taylor P. M. , Luna S. P. L. 
Published: November 2018

SummaryBackgroundStanding surgery avoids the risks of general anaesthesia in horses.ObjectivesTo assess sedation, antinociception and gastrointestinal motility in standing horses after a detomidine loading dose and 2‐h constant rate intravenous (i.v.) infusion, with or without methadone.Study designBlinded, randomised, crossover with seven healthy adult cross‐bred horses, three geldings and four females (404 ± 22 kg).MethodsFive i.v. treatments were administered to all horses with 1‐week washout period: saline (SAL), detomidine low (2.5 μg/kg bwt + 6.25 μg/kg bwt/h) (DL) and high doses (5 μg/kg bwt + 12.5 μg/kg bwt/h) (DH) alone or combined with methadone (0.2 mg/kg bwt + 0.05 mg/kg bwt/h), (DLM) and (DHM), respectively. Height of head above the ground (HHAG), electrical (ET), thermal (TT) and mechanical (MT) nociceptive thresholds and gastrointestinal motility were evaluated at predetermined times between 5 and 240 min. A mixed effect model and Kruskal–Wallis test were used to analyse normally and non‐normally distributed data, respectively.ResultsSedation (<50% basal HHAG) was achieved for the duration of the infusion, and for an additional 15 min in DH and DHM groups. Nociceptive thresholds were higher than baseline, to the greatest degree and the longest duration, with DHM (ET and TT for 135 min and MT for 150 min). After DH, TT was significantly higher than baseline from 30 to 120 min and MT from 15 to 135 min. After DLM, ET was increased at 90 min, TT at 30 min and MT for 120 min. Gastrointestinal motility was reduced for up to 135 min after DL, 150 min after DLM and 210 min after DH and DHM.Main limitationsNociceptive thresholds are not equivalent to surgical stimuli.ConclusionMethadone with the highest detomidine dose (DHM) may provide sufficient sedation and analgesia for standing surgical procedures and warrants further investigation.
Proceeding report of the Second Symposium on Hidradenitis Suppurativa Advances (SHSA) 2017
Authors: Shavit Eran , Alavi Afsaneh , Bechara Falk G. , Bennett Richard G. , Bourcier Marc , Cibotti Ricardo , Daveluy Steven , Frew John W. , Garg Amit , Hamzavi Iltefat , Hoffman Lauren K. , Hsaio Jenny , Kirby Joslyn Sciacca , Lev‐Tov Hadar , Martinez Erin , Micheletti Robert , Naik Haley B. , Nassif Aude , Nicholson Cynthia , Parks‐Miller Angie , Patel Zarine , Piguet Vincent , Ramesh Mayur , Resnik Barry , Sayed Christopher , Schultz Gregory , Siddiqui Aamir , Tan Jerry , Wortsman Ximena , Lowes Michelle A. 
Published: November 2018

AbstractThe 2nd Annual Symposium on Hidradenitis Suppurativa Advances (SHSA) took place on 03‐05 November 2017 in Detroit, Michigan, USA. This symposium was a joint meeting of the Hidradenitis Suppurativa Foundation (HSF Inc.) founded in the USA, and the Canadian Hidradenitis Suppurativa Foundation (CHSF). This was the second annual meeting of the SHSA with experts from different disciplines arriving from North America, Europe and Australia, in a joint aim to discuss most recent innovations, practical challenges and potential solutions to issues related in the management and care of Hidradenitis Suppurativa patients. The last session involved clinicians, patients and their families in an effort to educate them more about the disease.
Static assessment of plain/notched polylactide (PLA) 3D‐printed with different infill levels: Equivalent homogenised material concept and Theory of Critical Distances
Authors: Ahmed Adnan A. , Susmel Luca 
Published: November 2018

AbstractA novel approach based on the equivalent homogenised material concept and the theory of critical distances is formulated to perform static assessment of plain/notched objects of polylactide (PLA) when this polymer is additively manufactured with different infill levels. The key idea is that the internal net structure resulting from the 3D‐printing process can be modelled by keeping treating the material as linear elastic, continuum, homogenous, and isotropic, with the effect of the internal voids being taken into account in terms of change in mechanical/strength properties. This idea is initially used to assess the detrimental effect of the manufacturing voids on the static strength of the plain (ie, unnotched) material. This is done by addressing this problem in a Kitagawa‐Takahashi setting via the Theory of Critical Distances. Subsequently, this approach is extended to the static assessment of notched components of 3D‐printed PLA; ie, it is used to take into account simultaneously the effect of both manufacturing voids and macroscopic geometrical features. The accuracy and reliability of this design methodology were checked against a large number of experimental data generated by testing, under axial loading, plain specimens, as well as notched samples (including open notches) of PLA. These specimens were manufactured by making the infill level vary in the rage 10% to 90%. This validation exercise allowed us to demonstrate that the proposed approach is highly accurate, returning estimates falling within an error interval of ±20%. This remarkable level of accuracy strongly supports the idea that static assessment of 3D‐printed materials with complex geometries and manufactured with different infill levels can be performed by simply post‐processing conventional linear elastic finite element (FE) solid models, ie, without the need for modelling explicitly the detrimental effect of the manufacturing voids.
An interaction between climate change and infectious disease drove widespread amphibian declines
Authors: Cohen Jeremy M. , Civitello David J. , Venesky Matthew D. , McMahon Taegan A. , Rohr Jason R. 
Published: November 2018

AbstractClimate change might drive species declines by altering species interactions, such as host–parasite interactions. However, few studies have combined experiments, field data, and historical climate records to provide evidence that an interaction between climate change and disease caused any host declines. A recently proposed hypothesis, the thermal mismatch hypothesis, could identify host species that are vulnerable to disease under climate change because it predicts that cool‐ and warm‐adapted hosts should be vulnerable to disease at unusually warm and cool temperatures, respectively. Here, we conduct experiments on Atelopus zeteki, a critically endangered, captively bred frog that prefers relatively cool temperatures, and show that frogs have high pathogen loads and high mortality rates only when exposed to a combination of the pathogenic chytrid fungus (Batrachochytrium dendrobatidis) and high temperatures, as predicted by the thermal mismatch hypothesis. Further, we tested various hypotheses to explain recent declines experienced by species in the amphibian genus Atelopus that are thought to be associated with B. dendrobatidis and reveal that these declines are best explained by the thermal mismatch hypothesis. As in our experiments, only the combination of rapid increases in temperature and infectious disease could account for the patterns of declines, especially in species adapted to relatively cool environments. After combining experiments on declining hosts with spatiotemporal patterns in the field, our findings are consistent with the hypothesis that widespread species declines, including possible extinctions, have been driven by an interaction between increasing temperatures and infectious disease. Moreover, our findings suggest that hosts adapted to relatively cool conditions will be most vulnerable to the combination of increases in mean temperature and emerging infectious diseases.
Inhibitory effects of Sanguisorba officinalis root extract on HYBID (KIAA1199)‐mediated hyaluronan degradation and skin wrinkling
Authors: Yoshida H. , Yamazaki K. , Komiya A. , Aoki M. , Kasamatsu S. , Murata T. , Sayo T. , Cilek M. Z. , Okada Y. , Takahashi Y. 
Published: November 2018

AbstractObjectivesHyaluronan (HA), an important constituent of extracellular matrix in the skin, has many biological activities such as hydration that contributes to firmness and bounciness of the skin. We have reported that reduction in HA in the papillary dermis and over‐expression of HYBID (HYaluronan Binding protein Involved in hyaluronan Depolymerization, alias KIAA1199 or CEMIP), a key molecule for HA degradation in skin fibroblasts, are implicated in facial skin wrinkling in Japanese and Caucasian women. However, little or no information is available for substances which inhibit the HYBID‐mediated HA degradation.MethodsInhibition of Sanguisorba officinalis root extract and ziyuglycoside I, one of the components of Sanguisorba officinalis root extract, to the HYBID‐mediated HA degradation was assessed by size‐exclusion chromatography of HA depolymerized by stable transfectants of HYBID in HEK293 cells (HYBID/HEK293 cells) or normal human skin fibroblasts (Detroit 551 cells and NHDF‐Ad cells). The HYBID mRNA and protein expression was examined by quantitative real‐time PCR and immunoblotting in the skin fibroblasts treated with Sanguisorba officinalis root extract, and size distribution of newly produced HA was evaluated by preparing metabolically radiolabelled HA. A double‐blind, randomized and placebo‐controlled study was carried out in the 21 healthy Japanese women, who were topically treated with the formulation containing Sanguisorba officinalis root extract or the placebo on each side of the face including crow's foot area.ResultsSanguisorba officinalis root extract, but not ziyuglycoside I, abolished HYBID‐mediated HA degradation by HYBID/HEK293 cells. Sanguisorba officinalis root extract also inhibited HYBID‐mediated HA degradation in skin fibroblasts by down‐regulating HYBID mRNA and protein expression. Although control untreated skin fibroblasts produced polydispersed HA, the cells treated with Sanguisorba officinalis root extract produced only high‐molecular‐weight HA. Treatment with Sanguisorba officinalis root extract‐formulated lotion significantly improved skin elasticity, and reduced skin wrinkling scores at the outer eye corner compared with the placebo formulation.ConclusionSanguisorba officinalis root extract showed an anti‐HYBID‐mediated HA degradation activity and anti‐wrinkle activity on human facial skin, which is accompanied by the improvement in elasticity. Our study provides the possibility of a new strategy to inhibit HYBID‐mediated HA degradation for anti‐wrinkle care.
Religion’s influence on consumer response to moral vs. justice message appeals
Authors: Minton Elizabeth A. , Bret Leary R. , Upadhyaya Shikha 
Published: November 2018

AbstractBuilding from past research on religion and self‐construal, this research is the first known research to explore the relationships among religion (Western vs. Eastern vs. nonreligious), moral vs. justice message appeals, and ethical consumption. In two studies utilizing the context of Fair Trade products, we show differences in the effectiveness of moral and justice message appeals to encourage ethical consumption based on one’s religious or nonreligious affiliation. Study 1 uses an Amazon’s Mechanical Turk (MTurk) sample of 197 adults, finding through MANOVAs that moral (justice) appeals are the most effective at increasing purchase intentions for ethical goods among Western (nonreligious) consumers. Study 2 extends these questions to Western and Eastern religious consumers using a Qualtrics panel sample of 279 adults, finding through MANOVAs that moral (justice) appeals are more effective for Western (Eastern) religious consumers. Equally important, Study 2 results show that these effects occur regardless of religiosity level, emphasizing the need to understand consumers’ religious affiliation more so than religiosity level. Results from both studies also show that change efficacy positively influences Fair Trade purchase intentions which, surprisingly, encourages ethical disengagement. Results also examine the purchase motives of customers, finding nonreligious and Eastern religious consumers to be motivated by concern for others, while Western religious consumers are motivated out of concern for self. In sum, marketing practitioners desiring to encourage ethical consumption should use self‐based moral appeals (e.g., “do this because it is the right thing to do for yourself”) when targeting Western religious consumers or countries with predominantly Western religious followers, while using others‐based justice appeals (e.g., “do this because it is the fair thing to do for others”) when targeting Eastern or nonreligious consumers or countries mostly representing these affiliates.
Is buying counterfeit sinful? Investigation of consumers’ attitudes and purchase intentions of counterfeit products in a Muslim country
Authors: Souiden Nizar , Ladhari Riadh , Zarrouk Amri Anissa 
Published: November 2018

AbstractThe study investigates the effect of individuals’ ethics (i.e., idealism and relativism), religiosity (i.e., fear of divine punishment, interest in religion and practices, and beliefs in religion), and attitudes toward counterfeits (i.e., economic benefits and hedonic benefits) on purchase intentions of counterfeit products. Data were collected in Tunisia, a Muslim country showing a mixture of modern and conservative values. The analysis of variance on the data, collected among 217 participants, shows that religiosity, ethics, and attitudes, all influence the intent to buy counterfeits. The analysis further supports the stronger effect of perceived economic benefits on intentions of buying counterfeits. The study contributes to the development of knowledge about the effect of religiosity and ethics on consumption behavior.
Religiosity, materialism, consumer environmental predisposition. Some insights on vegan purchasing intentions in Italy
Authors: Raggiotto Francesco , Mason Michela Cesarina , Moretti Andrea 
Published: November 2018

AbstractThis paper explores the effects of environmental predisposition on purchasing intentions. The proposed model considers religiosity as a determinant of consumer environmental predisposition, adopting a multidimensional view entailing both intrinsic and extrinsic religiosity. Further, the effects of materialism are investigated, as it has been recognized as one of the most relevant hampering factors in determining consumer environmental predispositions and behaviors. Such factors appear intimately related, as materialism has been indicated as largely antithetical with respect to religion. Literature has suggested religiosity to be a key determinant of consumer environmental predispositions and behaviors. This might be even more important for specific, environmentally relevant consumer lifestyles. This work is hence set within vegan consumption. Veganism has been mostly related to specific religious beliefs (like Buddhism), according to which it represents a core component of larger worldviews. A structural equation model is proposed, based on a sample of 842 Italian consumers. Results show that religiosity exerts some effect on consumer environmental predisposition, and that, in turn, such predisposition determines vegan purchasing intentions. A split model is then proposed considering Christian and Buddhist consumers. Results of multigroup analysis show that religious influxes on consumer environmental predispositions might vary according to different religious faiths. Given the lack of previous empirical research, results of this study require further validation; still, they might provide some insights for managers, as markets related to environmentally relevant products and services are exhibiting a sustained growth.