bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fairy tale as a means of moral education of preschool children
Authors: Didyk O. V. 
Published: December 2024

Spiritual and moral upbringing is an urgent issue in modern society. The foundations of morality and values should be laid from the earliest and preschool age, when character and attitude to the world and people around us are formed. One of the most effective means of moral education is a fairy tale. A fairy tale is necessary for a baby, a child, and even a teenager. The tasks of a fairy tale are different for each age. A fairy tale comforts and entertains a baby, while a fairy tale educates preschoolers, gives them the opportunity to understand the moral laws of life and find answers to questions. In a preschool educational institution, spiritual and intellectual upbringing can be realized through several aspects of organized activities, one of the most striking examples of which is theatrical activity. In kindergarten, there is an opportunity to unleash the child's creative potential and foster a creative personality. Among the various traditional and non-traditional types of theater used in our kindergarten, the most appropriate for children of early and preschool age is “Theater on the Apron”. This type of theater is very relevant and mobile in our time. The teacher puts on an apron and thus embodies a theatrical performance. You can show a fairy tale, a joke or play it out with the kids in a group, on the street or in a shelter. Theatrical art is close and understandable to both children and adults, primarily because it is based on play. Collective theatrical activity is aimed at a holistic impact on the child's personality, its liberation, independent creativity, development of leading mental processes; promotes self-knowledge and self-expression of the individual, creates conditions for socialization, enhances adaptive abilities, corrects communication skills, helps to realize the feeling of satisfaction, joy, success. Involvement of kids in theatrical activities helps to master the world of human feelings, communication skills, and develop the ability to empathize with adults or peers. “Apron theater” is one of the brightest and most interesting ideas, because children can not only play some roles themselves, but also act together with adults and imitate them, kids learn to understand and use the language of facial expressions and gestures, improve their speech, in which emotional coloring and intonation are important components. It is the child's desire to participate in a theatrical performance and his or her emotional state that is very important. Children's desire to show what the character feels helps them to master the alphabet of moral relations. Empathy for the characters in the plays develops the child's feelings and understanding of bad and good human qualities. Familiarizing children with fairy tales and rhymes through theatrical activities develops not only mental functions, artistic abilities, creative potential, but also the universal ability to interact with others, to create in any field, and helps them to adapt to society and feel successful.
Pemanfaatan Media Sosial Instagram untuk Meningkatkan Kesadaran Penggunaan Kata Baku Bahasa Indonesia
Authors: Elfara Zahra Pranomo  , Fany Haifa Alia  , Respi Nurdian  , Adinda Dewi Lestari  , Anisa Apriliani  , Yuni Ertinawati  
Published: December 2024

The research aims to examine awareness of the use of standard indonesian words through soscial media namely. With the davelopment of social medai, the language used tends to be freer and less struvtured. The research method used is a qualitative method with a case study approach on accounts that focus on indonesian language learning. Data isi collected through observation of uploaded content as well as analysis of audience and follower interaction. The reserach results show tha the use of instagram can be an effective medium in introducing and educating the oublic about the importance of using standard words. The interactions that occur between account managers and followeres help strengthen understanding and practice of using indonesian properly and correctly. It can be concluded that 75% of instagram accounts still need coaching regarding standard words and 35% have had increased coaching so that this research is expected to be a focus for instagram users tp be wiser in using social media.
Advancing Disability Awareness in Medicine: An Interactive Video Learning Module to Promote Disability Competent Care
Authors: Schroth Samantha L. , Kaundinya Trisha , Adams Elizabeth J. , Metelski Jessica , Lewis Christopher , Arteaga Rebecca , Brucker James , Kessler Allison , Rydberg Leslie 
Published: December 2024

Background In a 2023 press release, the National Institutes of Health identified people with disabilities as a population with health disparities, supported by a plethora of research detailing how individuals with disabilities experience less preventative care and worse health outcomes than those without disabilities. Research into health disparities experienced by persons with disabilities is in its infancy with the majority of literature published after 2010. However, redundant themes contributing to these disparities have already been identified by healthcare providers including both implicit and explicit bias as contributory factors. Objective Few, if any, specific educational requirements exist for healthcare providers related to caring for patients with disabilities leading to a lack of knowledge and awareness regarding this patient population. This report describes and evaluates one step to combat health disparities among people with disability through the creation, implementation and evaluation of a virtual asynchronous training module to aid medical students in providing disability competent healthcare. Methods An interactive, online video module known as Advancing Disability Awareness in Medicine (ADAM) was developed to deliver critical knowledge relevant to providing equitable healthcare to persons with disabilities. This module includes information on the Americans with Disabilities Act, accommodations, and disability etiquette. The module was made available to first-year medical students as part of their required preparatory work for a clinical learning session where they would interact with persons with disabilities. A pre- and post-module survey, which included a 15-item knowledge test, was administered to all participants. Results Thirty-four medical students completed the pre-module survey and thirty-two completed the post-module survey. After completing the module, over 80% of students (n = 27) indicated feeling more comfortable for future interactions with a person identifying as having a mobility disability. Scores on the knowledge assessment increased from an average of 66.3% correct (9.94/15, pre-module) to 83.3% (12.50/15, post-module). Conclusion The ADAM module is an effective tool to increase student knowledge and comfort when interacting with patients with disabilities, especially those with mobility disabilities. Future iterations will involve distribution of the module to other health professional programs. By advocating for curricular inclusion of student education that combats biases about disability and informs trainees of anti-ableist mindsets, medical schools could make an important contribution to decreasing the health disparities experienced by patients with disabilities as these students develop disability competence and become stronger advocates for their patients with disabilities.
Illness Perception of Young Patients with HIV Infection
Authors: Arbune Manuela , Debita Mihaela , Mutica Mihai 
Published: December 2024

<p>The infection with the Human Immunodeficiency Virus (HIV) has become a chronic disease due to effective antiretroviral therapy (ARVT) that can provide complete and sustained viral suppression. The perception of HIV diagnosis has changed, from “condemnation to death” to long-term survival and life expectancy similar to the general population. The HIV epidemic in Romaniais predominant in cases diagnosed in infants born in 1987-1991, with nosocomially transmission during the first years of life. The aim of our work is to assess the perceptions of the course of the disease among persons living with HIV and the influence of factors such as demographic factors, time of HIV diagnostic, immunity and viral suppression under the ARVT. The brief version of Illness Perception Questionnaire (IPQ) for assessment of cognitive and emotional representations of illness, comprehensibility and an inventory questionnaire scoring symptoms were applied by a cross-sectional study among patients in the Daily Clinic for <em>HIV Evaluation and Treatment</em> from the Infectious Diseases Hospital in Galati, Romania. The most frequent age of patients with HIV from the clinic is under 35 years and they have good knowledge about their disease. The ARVT is efficiently controlling the clinical and viral markers of disease. However, half of the respondents are emotionally affected by living with HIV. The negative perception of HIV infection is more severe among females and people with viral failure treatment, although various and even contradictory perceptions were found, according to the answers collected. The adherence support of medical teams requires personalized management of HIV patients. <strong></strong></p><p class="11-SciencePG-Abstract-content"> </p>
Efficacy of Carbamazepine and Oxcarbazepine for Treating Trigeminal Neuralgia
Authors: Sarosh Iqbal  , Waqas Rashid  , Qurat ul Ain  , Tahmeena Atiq  , Rabia Noor  , Fahmoona Irfan  
Published: December 2024

Objective: To compare the efficacy of carbamazepine with oxcarbazepine for treating Trigeminal Neuralgia
Methodology: This was a randomized controlled trial conducted at Department of Oral Biology and Tooth Morphology, University Medical and Dental College (UMDC) Faisalabad, from October 2021 to April 2022. Total 56 patients (28 in each groups were randomized to revise carbamazepine and oxcarbazepine). Patient’s selection was based on a predefined inclusion and exclusion criteria. In Group-A patients were given Carbamazepine (200mg twice a day upto1800mg) and in Group-B patients were given Ox-carbamazepine (200mg BD daily up-to 1200mg). Safety was measured in terms of side effects seen in patients after treatment allocation. The response of the patients to therapeutic effectiveness of drug was decided based on the frequency of attacks, i.e., good response: no attacks of pain; average response: two to three attacks of pain per day; and nonresponsive with no decrease in the frequency of attacks of pain.
Results: Results showed higher efficacy for oxcarbazepine when compared with carbamazepine. i.e. Complete response= Carbamazepine: 42.9% vs. Oxcarbazepine:67.9%, p-value=0.017 Mean pain score was significantly better with oxcarbazepine (2.82±0.77) when compared with carbamazepine (4.36±0.86). i.e. p-value<0.001. Safety profile was also better for oxcarbazepine as that of carbamazepine. Frequency of adverse effects was higher for carbamazepine as that of Oxcarbazepine. i.e. 35.7% vs. 14.3%, p-value=0.064
Conclusion: It is concluded that oxycarbazepine is more effective in terms of efficacy, side effects and pain control as that of carbamazepine in the management of Trigeminal neuralgia.
Microalbuminuria In Newly Diabetes Mellitus Patients: Diagnosis, Screening and Increasing Public Awareness
Authors: Muhammad Tahir Younas  , Mukhtar Shoaib , Yousaf Sabeeha , Niazi Hira , Younas Sana 
Published: December 2024

Abstract

Objective: To promote public awareness about preventing chronic kidney disease by determining the prevalence and diagnosis of microalbuminuria in people with newly diagnosed diabetes.
Methodology: Cross Sectional Survey and analysis study was conducted in Department of Medicine PAF Hospital Islamabad from 1st January 2021 to 30th June 2021. A total of 111 newly diagnosed diabetic patients of both genders were included. All patients were sent to same hospital laboratory for urine test by Pathologist aiming microalbuminuria status. Data was collected regarding microalbuminuria from all patients and was noted as per operational definition.
Results: The Age range in this study was from 18 to 50 years with mean age of 42.504± 5.19 years and mean weight was 82.063±9.37 Kg. Majority of the patients were of male gender (81.1%). 71.2% patients had family history of diabetes. Microalbuminuria was observed in 47.7% patients. Due to a lack of screening and education, a considerable number of individuals with newly diagnosed diabetic patients already had microalbuminuria.
Conclusion: Prevalence of microalbuminuria was high in this patient population of newly diagnosed diabetes mellitus. These findings suggest that healthcare policy or research efforts may focus on reversing microalbuminuria in hopes of improving the prognosis of diabetic patients and preventing chronic kidney disease. Good glycemic control has been proved time and again in preventing cerebrovascular diseases and chronic kidney diseases.
Keywords: Diabetes, Newly Diagnosed, Microalbuminuria, Chronic Kidney Disease
Comparison of topical 5% Permethrin with topical 10% Sulphur in the treatment of Scabies
Authors: Nasir Aleena , Khan Abdul Haseeb , Sarwar Sara , Farooq Mahnoor , Sajjad Najia 
Published: December 2024

Objective: To compare the efficacy of topical 5% Permethrin and topical 10% Sulphur in the treatment of Scabies.
Design: Randomized controlled trial.
Place and duration of study: This study was conducted at the Department of Dermatology, Combined Military Hospital, Abbottabad, Pakistan, from March 2022 to September 2022.
Patients and methods: A total of 60 patients coming to outpatient department and diagnosed with scabies mites were randomized into two equal groups of 30 patients. Diagnosed patients on odd serial number were allocated to group A, treated with application of topical 5% Permethrin cream twice with one week interval, while patients reporting on even serial number were allocated to group B, treated with 10% Sulphur ointment and were told to apply this for two or three weeks. All patients were followed up at the intervals of 1, 2 and 4 weeks. Primary outcome was the comparison of efficacy of 5% Permethrin cream and 10% Sulphur ointment for the treatment of Scabies.
Results: At the first follow-up after 1 week, the efficacy of Permethrin was significantly higher (63.33%) compared to Sulphur group where no patient was cured (p< 0.001), while at 2nd follow-up after 2 weeks, the efficacy of Permethrin was 100%, while it was 43.33% in sulfur group (p< 0.001). However at the end of 3rd follow-up after 4 weeks, efficacy of both treatments was 100%.
Conclusion: The topical application of 5% Permethrin and 10% Sulphur was equally effective in 4 week time, however Permethrin cream showed faster cure in the treatment of Scabies
Upregulation of HPV16E1 and E7 expression and FOXO3a mRNA downregulation in high-grade cervical neoplasia
Authors: Sasivimolrattana Thanayod , Gunawan Aileen , Wattanathavorn Warattaya , Pholpong Chavis , Chaiwongkot Arkom , Bhattarakosol Pattarasinee , Bhattarakosol Parvapan 
Published: December 2024

Background
Cervical cancer remains a significant global health concern, ranking as the fourth most prevalent cancer among women worldwide. Human papillomaviruses (HPV) transcribe many genes that might be responsible for cervical cancer development. This study aims to investigate the correlation between the expression of HPV16 early genes and the mRNA expression of human FOXO3a, a tumor suppressor gene, in association with various stages of cervical precancerous lesions.

Methods
Eighty-five positive HPV16 DNA cervical swab samples were recruited and categorized based on cytology stages, i.e., negative for intraepithelial lesion or malignancy (NILM), atypical squamous cells of undetermined significance (ASC-US), low-grade squamous intraepithelial lesion (LSIL), atypical squamous cell cannot exclude HSIL (ASC-H), high-grade squamous intraepithelial lesion (HSIL). RT-qPCR was performed to amplify HPV16E1, E4, E6, E6*I, E7, and human FOXO3a mRNA expression in all samples. The relative expression of those genes was calculated using GAPDH as a control. Detection of FOXO3a mRNA expression in the cervical cancer cell line by RT-qPCR and meta-analysis of FOXO3a expression using the RNA-Seq dataset by GEPIA2 were analyzed to support the conclusions.

Results
Among the cervical samples, HPV16E1 and E7 were significantly increased expression correlating to disease severity. HPV16E4 mRNA expression was 100% detected in all LSIL samples, with a significant increase observed from normal to LSIL stages. Conversely, FOXO3a mRNA expression decreased with disease severity, and the lowest expression was observed in HSIL/squamous cell carcinoma (SCC) samples. In addition, similar results of FOXO3a downregulation were also found in the cervical cancer cell line and RNA-Seq dataset of cervical cancer samples.

Conclusion
HPV16 early mRNA levels, including E1 and E7, increase during cancer progression, and downregulation of FOXO3a mRNA is a characteristic of cervical cancer cells and HSIL/SCC. Additionally, HPV16E4 mRNA expression was consistently detected in all LSIL samples, suggesting the presence of active viral replication. These findings might lead to further investigation into the interplay between HPV gene expression and host cell factors for targeted therapeutic strategies in cervical cancer management.
The use of phosphate rock and plant growth promoting microorganisms for the management of Urochloa decumbens (Stapf.) R.D. Webster in acidic soils
Authors: Barbosa Alexandro , Reyes Isbelia , Valery Alexis , Chacón Labrador Carlos , Martínez Oscar , Alonso Maximo F. 
Published: December 2024

Background
Forage production in tropical soils is primarily limited by nutrient deficiencies, especially nitrogen (N) and phosphorus (P). The use of phosphate rock by plants is limited by its low and slow P availability and microbial phosphate solubilization is the main mechanism for P bioavailability in the soil-root system. The objectives of this study were (i) select a nitrogen-fixing bacteria which could be used as a co-inoculant with the Penicillium rugulosum IR94MF1 phosphate-solubilizing fungus and (ii) evaluate under field conditions the effect of inoculation combined with phosphate rock (PR) application on yield and nutrient absorption of a Urochloa decumbens pasture which was previously established in a low-fertility, acidic soil.

Methods
Various laboratory and greenhouse tests allowed for the selection of Enterobacter cloacae C17 as the co-inoculant bacteria with the IR94MF1 fungus. Later, under field conditions, a factorial, completely randomized block design was used to evaluate the inoculation with the IR94MF1 fungus, the IR94MF1+C17 co-inoculation, and a non-inoculated control. Two levels of fertilization with PR treatment (0 kg/ha and 200 kg/ha P2O5) were applied to each.

Results
During five consecutive harvests it was observed that the addition of biofertilizers significantly increased (p < 0.05) the herbage mass and N and P assimilation compared to the non-inoculated control. However, no statistically significant differences were observed for the PR application as P source.

Conclusion
P. rugulosum IR94MF1 is capable of solubilizing and accumulating P from the phosphate rock, making it available for plants growing in acid soils with low N content. These inoculants represent a good option as biofertilizers for tropical grasses already established in acidic soils with low N content.
Cyberbullying, cyber aggression, and cyber victimization in relation to adolescents’ dating and sexual behavior: An evolutionary perspective
Authors: Lapierre Kiana R. , Dane Andrew V. 
Published: August 2019

AbstractThis study examined adolescents’ cyberbullying, cyber aggression, and cyber victimization from an evolutionary perspective, extending previous research showing that traditional forms of bullying, aggression, and victimization are associated with reproductively relevant outcomes. Consistent with hypotheses based on theory and research linking bullying and aggression to intrasexual competition for mates, results indicated that cyber victimization was positively associated with a number of dating and sexual partners. Findings for cyber aggression were more complex, depending on the degree of cyber victimization experienced by the perpetrator, and the balance of power between the perpetrator and victim. Specifically, nonbullying cyber aggression by perpetrators with equal or less power than the victim had stronger positive relations with the number of dating or sexual partners when perpetrators experienced a high level of cyber victimhood. In contrast, cyberbullying by perpetrators with more power than the victim was negatively associated with the number of dating partners when the perpetrators’ exposure to cyber victimization was low. Although cyber aggression and cyber victimization are new forms of aggression that involve the use of modern electronic devices, the results of this study demonstrate the usefulness of viewing this behavior from an evolutionary perspective and show that adolescents are likely to use cyber aggression against rivals in the context of intrasexual competition for mates.
Photoactive Nanocarriers for Controlled Delivery
Authors: Xiong Qirong , Lim Yun , Li Di , Pu Kanyi , Liang Li , Duan Hongwei 
Published: August 2019

AbstractPhotoactive nanocarriers have emerged as robust and minimally invasive systems for the on‐demand delivery of active payloads. The easy manipulation offered by light irradiation as an external stimulus allows precise spatiotemporal control of payload release based on the time, intensity, location, and wavelength of light exposure. Compared to conventional passive delivery systems, photoactive nanocarriers offer the possibility of tailoring the release kinetics of the encapsulated active molecules, which is of considerable clinical relevance for targeted delivery to desired sites of interest. In this progress report, the recent advances in the design and fabrication of photoactive nanoplatforms based on three main modes of mechanisms: photochemical reactions, the photothermal effect, and photosensitization mechanism mediated by reactive oxygen species are highlighted. The combination of these mechanisms provides additional flexibility for the effective delivery of therapeutics and improved synergistic therapeutic effects. Finally, challenges in future perspectives on the development of photoactive nanomaterials and their medical translation are discussed.
Creating Directionality in Nanoporous Carbon Materials: Adjustable Combinations of Structural and Chemical Gradients
Authors: Bahner Jochen , Klinkenberg Nele , Frisch Marvin , Brauchle Lilly , Polarz Sebastian 
Published: August 2019

AbstractThe properties of porous materials benefit from hierarchical porosity. A less noted element of hierarchy is the occurrence of directionality in functional gradient materials. A sharp boundary is replaced by a transition from one feature to the next. The number of cases known for porous materials with either structural or chemical gradients is small. A method capable of generating combinations of structural and chemical gradients in one material does not exist. Such a method is presented with a focus on silver and nitrogen containing carbon materials because of the potential of this system for electrocatalytic CO2 reduction. A structural gradient results from controlled separation using ultracentrifugation of a binary mixture of template particles in a resorcinol–formaldehyde (RF) sol as carbon precursor. A new level of complexity can be reached, if the surfaces of the template particles are chemically modified. Although the template is removed during carbonization, the modification (Ag, N) becomes integrated into the material. Understanding how modified and unmodified large and small particles sediment in the RF sol enables almost infinite variability of combinations: chemically graded but structurally homogeneous materials and vice versa. Ultimately, a material containing one structural gradient and two chemical gradients with opposing directions is introduced.