bluuebunny/crossref_metadata_2025_split huggingface dataset:
The procurement and use of knappable glassy volcanic raw material from the late Pleistocene Pilauco site, Chilean Northwestern Patagonia
Authors: Navarro‐Harris Ximena , Pino Mario , Guzmán‐Marín Pedro , Lira María Paz , Labarca Rafael , Corgne Alexandre 
Published: March 2019

AbstractIn this study we used a multidisciplinary approach, coupling morphological, geological, geochemical, and statistical analyses to investigate the provenance of rhyodacitic and dacitic glass knapped at the Pilauco site (40°34′11” S, 73°06′17” W; 13,570 ± 70–12,540 ± 90 14C year BP) in northwestern Chilean Patagonia. A morphotechnological analysis was performed on the entire lithic assemblage, which is composed of cores, retouched and unretouched unifacial flakes, and small pieces of debitage, some of them closely associated with Notiomastodon aff. N. platensis gomphothere bones. Sixty‐two archeological and geological samples were analyzed by inductively coupled plasma mass spectrometry revealing a wide range of basaltic to rhyodacitic compositions. The archeological knappable dacitic and rhyodacitic glasses were recovered from pebbles deposited mainly on a beach away from the site, as deduced by the presence of minute and dense crescentic percussion marks on the cortexes. Geochemical trace element analysis suggests that the Puyehue–Cordón Caulle Volcanic Complex is the most likely source for the volcanic glass artifacts at Pilauco. The new morphotechnological and provenance record and improved stratigraphic sequences highlight the Pilauco site as an important contribution for the diversity of the South American geoarchaeological context.
Bayesian meta‐analysis across genome‐wide association studies of diverse phenotypes
Authors: Trochet Holly , Pirinen Matti , Band Gavin , Jostins Luke , McVean Gilean , Spencer Chris C. A. 
Published: March 2019

AbstractGenome‐wide association studies (GWAS) are a powerful tool for understanding the genetic basis of diseases and traits, but most studies have been conducted in isolation, with a focus on either a single or a set of closely related phenotypes. We describe MetABF, a simple Bayesian framework for performing integrative meta‐analysis across multiple GWAS using summary statistics. The approach is applicable across a wide range of study designs and can increase the power by 50% compared with standard frequentist tests when only a subset of studies have a true effect. We demonstrate its utility in a meta‐analysis of 20 diverse GWAS which were part of the Wellcome Trust Case Control Consortium 2. The novelty of the approach is its ability to explore, and assess the evidence for a range of possible true patterns of association across studies in a computationally efficient framework.
Late Carboniferous to Early Permian adakitic rocks and fractionated I‐type granites in the southern West Junggar terrane, NW China: Implications for the final closure of the Junggar–Balkhash Ocean
Authors: Liu Bo , Han Bao‐Fu , Ren Rong , Zheng Bo , Chen Jia‐Fu 
Published: March 2019

The final closure of the Junggar–Balkhash Ocean resulted in the amalgamation of the circum‐Balkash–Junggar segments of the south‐western Central Asian Orogenic Belt, but the exact timing of its closure remains uncertain. Here, we use zircon U–Pb and whole‐rock chemical data for the adakitic rocks and fractionated I‐type granitoids in the Alashankou area of the southern West Junggar terrane (WJT) to investigate their petrogenesis and tectonic implications for the closure of the Junggar–Balkhash Ocean. The adakitic rocks were emplaced at 313–295 Ma and exhibit high Sr/Y ratios of 121–229. Their low MgO contents (0.91–2.09 wt%), Co, Cr, and Ni concentrations, initial 87Sr/86Sr ratios, and high εNd(t) values, indicate an origin from partial melting of juvenile lower crust under garnet‐amphibolite‐facies conditions triggered by basaltic underplating. By comparison, the fractionated I‐type granitic plutons (283–273 Ma) are weakly peraluminous and distinctive in terms of their low MgO contents (0.31–0.39 wt%) and strongly negative Nb, Ta, P, Eu, and Ti anomalies. These features, along with their higher initial 87Sr/86Sr ratios and lower εNd(t) values, suggest derivation by partial melting of a depleted mantle source and/or of newly underplated lower crust with crustal contamination. Given the Late Carboniferous depositional hiatus and post‐orogenic strike‐slip faulting and absence of post‐Devonian ophiolites and post‐Palaeozoic magmatic events in the WJT, the widespread occurrence of Late Carboniferous to Permian compositionally diverse granitoids (including the adakitic rocks, high‐Mg dioritic rocks, and I‐ and A‐type granitoids) and coeval mafic dykes can be best explained by a post‐collisional slab breakoff model. Together with other lines of geological evidence in the circum‐Balkash–Junggar area, we propose that the Junggar–Balkhash Ocean should have been closed at the beginning of the Late Carboniferous (~320 Ma), consistent with the closure time (~325–300 Ma) for regional major ocean basins.
Different roles of frontal versus striatal atrophy in HIV‐associated neurocognitive disorders
Authors: Israel Sarah M. , Hassanzadeh‐Behbahani Shiva , Turkeltaub Peter E. , Moore David J. , Ellis Ronald J. , Jiang Xiong 
Published: March 2019

AbstractGray matter (GM) atrophy is frequently detected in persons living with HIV, even in the era of combination antiretroviral therapy (cART), but the specificity of regions affected remains elusive. For instance, which regions are consistently affected in HIV? In addition, atrophy at which regions is frequently associated with neurocognitive impairment in HIV? Resolving these questions can potentially help to establish the possible neural profiles of HIV‐associated neurocognitive disorders (HAND) severity, which currently is solely defined by neurobehavioral assessments. Here, we addressed these questions using a novel meta‐analysis technique, the colocalization‐likelihood estimation (CLE) technique, to quantitatively synthesize the findings of GM atrophy in HIV+ adults. Twenty‐one of 386 studies published between 1988 and November 2017 and identified in PubMed were selected, plus four identified in other resources. In the end, 25 studies (1,370 HIV+ adults, 889 HIV− controls) were included in the meta‐analysis. This technique revealed that GM atrophy in HIV+ adults was dominated by two distinct but nonexclusive profiles: frontal (including anterior cingulate cortex, [ACC]) atrophy, which was associated withHIV‐disease and consistently differentiated HIV+ adults from HIV− controls; and caudate/striatum atrophy, which was associated with neurocognitive impairment. The critical role of caudate/striatum atrophy in neurocognitive impairment was further supported by a separate data analysis, which examined the findings of correlation analyses between GM and neurocognitive performance. These results suggest that the frontal lobe and the striatum play critical but differential roles in HAND. A neural model of HAND severity was proposed with several testable predictions.
Assessing issues associated with a time‐integrated fluvial fine sediment sampler
Authors: Goharrokhi Masoud , Pahlavan Hoda , Lobb David A. , Owens Philip N. , Clark Shawn P. 
Published: March 2019

AbstractCollecting a representative time‐integrated sample of fluvial fine‐grained suspended sediment (<63 μm) is an important requirement for the understanding of environmental, geomorphological, and hydrological processes operating within watersheds. This study (a) characterized the hydrodynamic behaviour of a commonly used time‐integrated fine sediment sampler (TIFSS) using an acoustic Doppler velocimeter (ADV) in controlled laboratory conditions and (b) measured the mass collection efficiency (MCE) of the sampler by an acoustic Doppler current profiler under field conditions. The laboratory results indicated that the hydrodynamic evaluations associated with the original development of the TIFSS involved an underestimation of the inlet flow velocity of the sampler that results in a significant overestimation of the theoretical MCE. The ADV data illustrated that the ratio of the inlet flow velocity of the sampler to the ambient velocity was 87% and consequently, it can be assumed that a representative sample of the ambient fine suspended particles entered into the sampler. The field results showed that the particle size distribution of the sediment collected by the TIFSS was statistically similar to that for the ambient sediment in the Red River, Manitoba, Canada. The MCE of the TIFSS in the field trials appeared to be as low as 10%. Collecting a representative sample in the field was consistent with the previous findings that the TIFSS is a suitable sampler for the collection of a representative sample of sufficient mass (e.g., >1 g) for the investigation of the properties of fluvial fine‐grained suspended sediment. Hydrodynamic evaluation of the TIFSS under a wider range of hydraulic conditions is suggested to assess the performance of the sampler during high run‐off events.
Synthesis of Colloidal Halide Perovskite Quantum Dots/Nanocrystals: Progresses and Advances
Authors: Zhao Yongli , Li Jinhang , Dong Yuhui , Song Jizhong 
Published: March 2019

AbstractColloidal halide perovskite (CHP) quantum dots (QDs)/nanocrystals (NCs) have superior optoelectronic properties, such as high optical absorption coefficient, high photoluminescence quantum yield (PLQY), tunable bandgap, composition‐related luminescence, and low manufacturing cost, which have been considered as promising low‐dimensional semiconductor materials. Profiting from these unique characteristics, CHP NCs could be widely used in various optoelectronic devices, including light‐emitting diodes (LEDs), photodetectors (PDs), solar cells (SCs), and lasers. Synthesis is the basis for the wide use of CHP NCs, which plays a vital role in the research, development and application of CHPs. Therefore, we summarize the recent synthetic strategies, and their influencing factors (e. g., the effects of ligands, and anion exchange). Besides, a summary of their optoelectronic applications is plainly mentioned. Finally, we make a brief prospect and summarize the current problems and possible solutions of this area.
Linking social and economic responsibilities and financial performance: The assisting role of innovation for an oil engineering and development company
Authors: Oskouei Zahra Hashemi 
Published: March 2019

AbstractSocial and economic responsibilities of companies lead to positive and successful financial performance of companies, and they lead to improve the company ratings and evaluations among consumers. In addition, innovation in products and the process of management make it competitive, and they considerably contribute to the growth of the company's performance. Therefore, the present research aims to study the relationship between the social and economic responsibilities with the financial performance through relying on the facilitating role of innovation. To accomplish this, 278 data samples were collected from the staff working for an oil engineering and development company (in the period of December 2017 to March 2018) based on a Likert scale questionnaire. Then the results were analysed using structural equation models together with Amos24 and SPSS22 software. The results of this study showed that the impact of economic responsibility on innovation is only positive and significant and the social responsibility cannot affect innovation changes. Also, innovation is ineffective in the financial performance of the oil engineering and development company. Hence, it is essential to use effective polices related to the companies' economic responsibility necessary for obtaining better long‐term innovations. Moreover, it is suggested that the managers provide insights for improving the role of social responsibility in achieving future benefits and higher financial performances.
A 1‐year comparison of TCu380Ag versus TCu380A intrauterine contraceptive devices in India
Authors: Kriplani Alka , Sehgal Rohini , Konar Hiralal , Vivekanand Achanta , Vanamail Perumal , Purandare Chittaranjan N. 
Published: March 2019

AbstractObjectiveTo compare TCu380Ag and TCu380A intrauterine contraceptive devices after 1 year of use.MethodsA prospective randomized controlled trial was conducted among healthy married women aged 20–35 years who attended the family planning clinics of three tertiary centers in India between August 1, 2015, to March 31, 2018. The TCu380Ag group (n=300) received one of three sizes of this device depending on uterocervical length: maxi (8.0–9.0 cm), normal (7.0–8.5 cm), or mini (6.0–7.5 cm). The remaining 300 participants received TCu380A. Follow‐up was conducted at 3‐monthly intervals to assess continuation rate, acceptability, efficacy, adverse effects, and complications.ResultsThe TCu380Ag group had a higher continuation rate than the TCu380A group at 1 year (84.0% vs 75.8%; P=0.01), with an efficacy of 99.6% versus 100.0% (P>0.05). Overall estimated continuation rates were 94.5% (95% confidence interval [CI] 91.7%–96.4%) and 88.4% (95% CI 83.2%–91.5%), respectively (P=0.026). Use of TCu380Ag was associated with fewer adverse effects (heavy menstrual bleeding, abdominal pain, or expulsion) when compared with TCu380A (P>0.05 for all comparisons). Discontinuation rates owing to adverse effects were 6.59% for TCu380Ag versus 13.26% for TCu380A (P=0.01).ConclusionsVarying sizes of TCu380Ag could provide an alternative to TCu380A.
A review of rechargeable batteries for portable electronic devices
Authors: Liang Yeru , Zhao Chen‐Zi , Yuan Hong , Chen Yuan , Zhang Weicai , Huang Jia‐Qi , Yu Dingshan , Liu Yingliang , Titirici Maria‐Magdalena , Chueh Yu‐Lun , Yu Haijun , Zhang Qiang 
Published: March 2019

AbstractPortable electronic devices (PEDs) are promising information‐exchange platforms for real‐time responses. Their performance is becoming more and more sensitive to energy consumption. Rechargeable batteries are the primary energy source of PEDs and hold the key to guarantee their desired performance stability. With the remarkable progress in battery technologies, multifunctional PEDs have constantly been emerging to meet the requests of our daily life conveniently. The ongoing surge in demand for high‐performance PEDs inspires the relentless pursuit of even more powerful rechargeable battery systems in turn. In this review, we present how battery technologies contribute to the fast rise of PEDs in the last decades. First, a comprehensive overview of historical advances in PEDs is outlined. Next, four types of representative rechargeable batteries and their impacts on the practical development of PEDs are described comprehensively. The development trends toward a new generation of batteries and the future research focuses are also presented.
Feasibility of pharmacists to contribute to multicenter emergency medicine research
Authors: Patanwala Asad E. , Weant Kyle A. , Acquisto Nicole M. 
Published: March 2019

ObjectivesA flexible, rapid, and scalable multicenter network is needed for pharmacotherapy research in emergency medicine (EM). The objective of this study was to evaluate the types of studies EM pharmacists are willing to conduct in multicenter research.MethodsThis was a cross‐sectional national survey conducted in the United States. The survey was developed using an iterative process to establish face and content validity. Members of the American College of Clinical Pharmacy EM Practice and Research Network were invited to complete the survey using Research Electronic Data Capture. Online consent was obtained prior to survey completion. The survey consisted of 14 questions, which was expected to take less than 5 minutes to complete. Data were descriptively evaluated.ResultsThere were a total of 637 potentially eligible participants for the survey. Of these, 98 completed the survey (15% response rate). In terms of types of studies, 91 (93%) would participate in studies involving retrospective acquisition of data, 83 (85%) in observational studies not requiring patient consent, 48 (49%) in observational studies involving a patient consent procedure, and 26 (27%) in implementing and conducting a clinical trial. Overall, 85 (87%) would participate without funding and 66 (67%) would participate without receiving authorship.ConclusionsA substantial number of EM pharmacists are willing to participate in multicenter research. The number of participants decreases without provision of authorship or for studies involving patient consent.
A novel braided biodegradable stent for use in congenital heart disease: Short‐term results in porcine iliac artery
Authors: Sun Jing , Sun Kun , Bai Kai , Chen Sun , Wang Fujun , Zhao Fan , Hong Nanchao , Hu Hanbo 
Published: March 2019

AbstractTo evaluate the properties and efficacy of a novel braided biodegradable stent (BBS) consisting of poly (p‐dioxanone) (PPDO) and polycaprolactone (PCL) for usage in children with congenital cardiovascular diseases. PCL/PPDO composite filaments were fabricated by coating PCL layers onto PPDO filaments, which were fused with PPDO monofilaments to form the BBS. Physical properties of BBSs including elastic recovery rate, deformation rate, and mechanical characteristics with adjunctive post‐dilation were evaluated by radial force‐tests. Ten BBS stents and 10 metallic wall stents (WS) as controls were implanted into the common carotid arteries of 10 pigs and angiography as well as histological examinations were performed 4 and 8 weeks after implantation. An 8 mm BBS with adjunctive post‐dilation had the best morphological retention and dimension stability being similar to an 8 mm WS. Luminal gain percentages of BBS and WS immediately, 4 weeks and 8 weeks after implantation were 20.44 ± 2.82% and 27.08 ± 0.88%, 12.34 ± 0.18% and 17.32 ± 8.24%, as well as −1.76 ± 2.45% and − 0.98 ± 3.23%. Luminal areas, internal elastic laminas, neointimal areas, neointimal thicknesses, and area stenosis were not significantly different at 4 weeks and 8 weeks after implantation. Injury and inflammation were similar in both groups and no malposition, thrombosis or dissection occurred. BBS with adjunctive post‐dilation showed good physical properties and mechanical stability noninferior to WS. In vivo evaluations showed that a BBS with post‐ballooning had similar short‐term outcomes as a WS. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1667–1677, 2019.
IR820‐loaded PLGA nanoparticles for photothermal therapy of triple‐negative breast cancer
Authors: Valcourt Danielle M. , Dang Megan N. , Day Emily S. 
Published: March 2019

AbstractTriple‐negative breast cancer (TNBC) accounts for 15–25% of breast cancer cases and lacks expression of the three most common receptors seen on other subtypes of breast cancer. This lack of expression makes TNBC unsusceptible to currently available targeted or hormonal therapies, so new treatment strategies are desperately needed. Photothermal therapy (PTT), which utilizes nanoparticles (NPs) embedded in tumors as exogenous energy absorbers to convert externally applied near‐infrared (NIR) light into heat to ablate cancer cells, has shown promise as an alternative strategy. However, it typically uses gold‐based NPs that will remain in the body for extended period of time with unknown long‐term health effects. To enable PTT with biodegradable, polymeric NPs, we encapsulated the NIR‐absorbing dye IR820 in poly(lactic‐co‐glycolic acid) (PLGA) NPs. We characterized the physicochemical properties of these IR820‐loaded PLGA NPs and evaluated their performance as PTT agents using both in vitro and in vivo models of TNBC. The results demonstrate that these NPs are potent mediators of PTT that induce cell death primarily through apoptosis to effectively hinder the growth of TNBC tumors. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1702–1712, 2019.
A novel, doped calcium silicate bioceramic synthesized by sol–gel method: Investigation of setting time and biological properties
Authors: Abdalla Mohamed Mahmoud , Lung Christie Ying Kei , Neelakantan Prasanna , Matinlinna Jukka Pekka 
Published: March 2019

AbstractThe aim of the current study was to synthesize a fast‐setting ion‐doped calcium silicate bioceramic by the sol–gel method and to characterize its in vitro apatite‐forming ability and cell viability. Calcium silicate (CS), doped calcium silicate with zinc and magnesium, with Ca/Zn molar ratios of 6.7:1 (DCS1), and 4.5:1 (DCS2), were synthesized by the sol–gel method. Matreva white MTA (WMTA, Matreva, CA, Egypt) was used as a control. The synthesized powders were characterized by x‐ray diffraction. Setting time was measured using the Gilmore needle indentation technique. The in vitro apatite‐forming ability of the materials was evaluated by scanning electron microscope and energy dispersive X‐ray. NIH3T3‐E1 cells viability was tested using MTT assay. The ion release of Ca, Si, Zn, and Mg was measured using inductive coupled plasma‐optical emission spectroscopy (ICP‐OES). One‐way ANOVA was used to analyze setting time results. The Tukey's HSD post hoc test was used to establish significance (p < 0.001). For nonparametric data, the Kruskal–Wallis H test with Dunn's correction for post hoc comparison was used (p < 0.05). CS, DCS1, and DCS2 showed a significant decrease in setting time 33 ± 1.63 min, 28 ± 1.63 min, and 41.75 ± 2.87 min, respectively, compared to WMTA 91 ± 3.16 min (p < 0.001). DCS1 showed the highest apatite‐forming ability and cell viability compared to the other groups. Ca and Si ions release decreased in both DCS1 and DCS2. The physical and biological properties of CS can be successfully improved by the sol–gel synthesis and ions doping. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:56–66, 2020.
Chemokine (C‐X‐C motif) ligand 14 contributes to lipopolysaccharide‐induced fibrogenesis in mouse L929 fibroblasts via modulating PPM1A
Authors: Li Li , Li Qiuhong , Wei Lei , Wang Zhongfu , Ma Wei , Liu Fangying , Shen Yanhua , Zhang Shanfang , Zhang Xiulian , Li Huiping , Qian Yechang 
Published: March 2019

AbstractHerein, we found that serum chemokine ligand 14 (CXCL14) was significantly enhanced in patients with idiopathic pulmonary fibrosis (IPF). In our current study, mouse L929 fibroblasts were stimulated with lipopolysaccharide (LPS) (100 ng/mL). Cell proliferation, the levels of matrix metalloproteinase 2 (MMP2) and MMP9, as well as extracellular matrix (ECM) content were assessed to evaluate the fibrogenesis of L929 cells. Proliferating cell nuclear antigen and cell viability were assessed to evaluate cell proliferation. Hydroxyproline (Hyp), collagen I/III, connective tissue growth factor (CTGF), and phosphorylated Smad2/3 (p‐Smad2/3) were assessed to evaluate ECM secretion and deposition. α‐Smooth muscle actin (α‐SMA) was used to measure the occurrence of differentiation from fibroblast toward myofibroblast. Our data suggested that knockdown of CXCL14 prevented LPS‐induced fibrogenesis of L929 cells through inhibiting cell proliferation and decreasing the expression of MMP2/9, Hyp, collagen I/III, CTGF, p‐Smad2/3, and α‐SMA. Notably, upregulation of protein phosphatase magnesium‐dependent 1A (PPM1A) was involved in this process. On the contrary, recombinant CXCL14 protein led to an opposite effect. We first suggested that overexpression of PPM1A ameliorated LPS‐induced fibrogenesis. Furthermore, we substantiated that knockdown of CXCL14 exerted an antifibrotic effect in IPF in vitro probably via the upregulation of PPM1A. Besides, evidently enhanced CXCL14, yet reduced PPM1A, was found in bleomycin‐induced rat pulmonary fibrosis, confirming the roles of CXCL14 and its potential association with PPM1A in IPF in vivo. In conclusion, CXCL14 could be considered as a therapeutic target for preventing fibrogenesis of mouse L929 fibroblasts.