bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three‐Year Clinical and Hemodynamic Evaluation of the Hydra Self‐Expanding Transcatheter Aortic Valve in Patients With Severe Aortic Stenosis
Authors: Bajoras Vilhelmas , Dabrowski Maciej , Davidavicius Giedrius , Cesna Sigitas , Peciuraite Dovile , Wykrzykowska Joanna J. , Witkowski Adam , Stoklosa Patrycjusz , Sudhir Krishnankutty , Aidietis Audrius 
Published: November 2024

ABSTRACTBackgroundThe Hydra CE study revealed 1‐year favorable efficacy of TAVR, showing a large effective orifice area (EOA), low gradient, and acceptable complication rates.AimsWe evaluated the 3‐year clinical and hemodynamic outcomes of Hydra self‐expanding transcatheter aortic valve (manufactured by Vascular Innovations Co Ltd, Nonthaburi, Thailand; a subsidiary of Sahajanand Medical Technologies Limited, India) in patients with symptomatic severe aortic stenosis at high or extremely high surgical risk.MethodsThe Hydra CE study was a prospective, multicenter, single‐arm study. A total of 157 patients were enrolled in the study, out of whom 54 patients from two centers (Lithuania and Poland) had provided consent for long‐term follow‐up at recruitment, with a planned 5‐year follow‐up period. The primary endpoint was all‐cause mortality, and patients were followed up for up to 3 years, with an assessment of clinical and echocardiographic outcomes.ResultsAmong the 54 patients, the average age was 81.0 ± 4.1 years. The mean STS score was 3.2 ± 2.0%. At 3 years, all‐cause mortality had occurred in 14.8% of patients, including 3.7% cardiovascular deaths and 1.9% device‐related deaths. There was a progressive enhancement in EOA that is, 0.68 ± 0.15 cm2 at baseline to 1.97 ± 0.52 cm2 at 3 years (p < 0.001) as well as significant improvement in the mean aortic valve gradient that is, 53.4 ± 14.24 mmHg at baseline to 8.6 ± 2.80 mmHg at 3 years (p < 0.001). New permanent pacemaker implantation rates up to 3‐year follow‐up was 12.9%.ConclusionThe 3‐year results of the Hydra CE study demonstrated consistent improvements in hemodynamics over time. The study also revealed favorable safety and efficacy trends, along with low occurrences of new permanent pacemaker implantations and paravalvular leaks.
Recruitment and retention of minoritized students in CACREP‐accredited counseling programs
Authors: Clark Madeline , Kempf Janet , Paul Dinisha , Sheikh Sahar , Gleason Brett , Odrunia Karisa 
Published: November 2024

AbstractThe recruitment and retention of minoritized students is critical for diversifying the counseling profession. Accreditation standards and scholarship provide little guidance on best practices. We sampled 38 administrators from the Council for Accreditation of Counseling and Related Educational Programs to understand recruitment and retention practices for minoritized students. We found four themes and provide implications for counselor education.
Influence of tillage and rotation sequence on corn response and planting pattern
Authors: Tilley M. Scott , Jordan David L. , Vann Rachel A. , Gatiboni Luke , Heiniger Ronnie W. 
Published: November 2024

Plain Language SummaryCorn (Zea mays L.), cotton (Gossypium hirsutum L.), and peanut (Arachis hypogaea L.) are traditional crops grown in the southeast region of the United States. Row crop producers have adopted many strategies to reduce the presence of disease and parasitic nematodes among peanut. One management strategy that has not been considered is the potential use of twin‐row planting patterns compared to single‐row cropping systems under various tillage practices. The objective of this study is to determine if corn yield differs when comparing twin‐row and single‐row planting patterns when planted in various rotation sequences following corn, cotton, and peanut in continuous strip tillage or conventional tillage. Results indicated that corn yield increased as the length of rotation increased relative to peanut. Furthermore, the increase in the planting of cotton within the rotation also increased corn yield. The use of strip tillage increased corn yield compared to conventional. No significant yield increase was seen when comparing twin‐row to single‐row.
Evaluating the agronomic and economic benefit of including spinosad with and without pyrethroid insecticides in bermudagrass stem maggot treatments
Authors: Burt Justin C. , Baxter Lisa L. , Anderson William F. , Hancock Guy A. , Secor William G. 
Published: November 2024

AbstractThe bermudagrass stem maggot (BSM; Atherigona reversura Villeneuve) is known to have a detrimental effect on bermudagrass (Cynodon spp.). Currently, two strategically timed pyrethroid applications are recommended for BSM suppression in each harvest cycle. However, producers are interested in applying spinosad because of its residual effects for other insects or reducing the number of pyrethroid applications to cut input costs. Therefore, the objective of this study was to determine the agronomic and economic implications of one or multiple pyrethroid (zeta‐cypermethrin) and/or spinosad applications on ‘Alicia’ and ‘Tifton 85’ bermudagrasses. Generally, zeta‐cypermethrin treatments resulted in a greater herbage accumulation compared to the untreated control in both cultivars. Regardless of cultivar, spinosad only treatments did not improve upon the herbage accumulation observed in the untreated control. Crude protein and total digestible nutrients were not affected by insecticide treatments in either cultivar. Finally, two zeta‐cypermethrin applications resulted in greater net profit compared to other insecticide treatments. These data illustrate that there is not yet an alternative for two pyrethroid applications for BSM suppression. Ongoing research and breeding efforts are focused on BSM tolerance and reduced pyrethroid usage to prevent resistance to the insecticide.
Pd‐Catalyzed Site‐Selective Defluorinative Etherification Between Unactivated Perfluoroarenes and Hydrobenzoxazoles
Authors: Wang Yaping , Wang Luyao , Qin Yibo , Xiong Heng‐Ying , Zhang Guangwu 
Published: November 2024

AbstractPolyfluoroaryl ethers represent an important framework of biologically active molecules and materials. Owing to the strong bond dissociation energy of C−F bond, selectivity and other issues, transition metal‐catalyzed synthesis of polyfluoroaryl ethers from perfluoroarenes via the activation of C−F bond is challenging and underdeveloped, as compared to the well‐documented C−O bond formation starting from aryl iodides, aryl bromides or aryl chlorides. Herein, an unprecedented Pd‐catalyzed defluorinative etherification for the synthesis of polyfluoroaryl ether skeletons using hydrobenzoxazoles as phenol surrogate, has been reported. The substrate scope for this protocol is broad, with respect to hydrobenzoxazoles and perfluoroarenes, under mild reaction conditions. More importantly, challenging alkenyl and alkynyl substituted polyfluoroarenes could be successfully used as the cou‐pling component for Pd‐catalyzed etherification reaction. Density functional theory (DFT) calculations were employed to investigate the reaction mechanism, which suggested that oxidative addition between polyfluorobenzene and Pd(0) constituted the rate‐determining step.
Art and Inspiration: Edouard Benedictus and the Invention of Laminated Safety Glass
Authors: Rasmussen Seth C. 
Published: November 2024

AbstractThe invention of laminated safety glass is attributed to the French chemist and artist Edouard Benedictus (1878–1930), who developed the innovation known as Triplex glass after inspiration struck via a fortuitous laboratory accident. Licensed first to the English Triplex Safety Glass Company in 1912, with production later carried out in the US, Triplex glass was first applied to automobiles during the first World War. While the story of his lab accident can be found in many sources, it has become more legend than historical fact. To rectify this, a more accurate account of Benedictus and the development of Triplex glass is presented based on historical records.
Intrusive Thoughts and Images in Health Anxiety: Rates, Characteristics, and Responses
Authors: Windsor Natalie A. , Li Sophie H. , Joubert Amy , Upton Emily , Moulds Michelle , Newby Jill M. 
Published: November 2024

ABSTRACTObjectivesIntrusive thoughts and images in Health Anxiety are poorly understood. The current study aims to explore the rates and nature of health‐related intrusive thoughts and images in people with and without Health Anxiety.DesignWe used a cross‐sectional interview and survey design recruiting 82 participants (Health Anxiety: n = 37; control: n = 45).MethodsParticipants completed a diagnostic and clinical interview, and questionnaires to assess experiences and appraisals of intrusive thoughts and images about health.ResultsExperiencing an intrusive thought or image was common in both groups (Health Anxiety: 89.2%, control: 55.6%). However, the Health Anxiety group reported their intrusive thoughts as more frequent, more distressing, and associated them with more negative emotions than controls. Further, the Health Anxiety group had increased negative appraisals and specific maladaptive behaviours for both intrusive thoughts and intrusive images compared to controls.ConclusionsWe conclude that, relative to controls, individuals with Health Anxiety experience intrusive thoughts and images more intensely and negatively, have more dysfunctional appraisals of them, and are more likely to respond to them with specific maladaptive behaviours. As such, addressing intrusive thoughts and images as part of cognitive behavioural interventions for Health Anxiety is warranted.
Comparative Analysis and Improvement of Generalized Droop Control and Virtual Synchronous Generator for Rate of Change of Frequency Constraint and Transient Power Suppression
Authors: Wu Qinghui , Zhang Chunjiang , Zhao Xiaojun , Lin Hengwei , Zhang Xiaoyu , Wang Fuxi 
Published: November 2024

ABSTRACTSince the microgrid lacks inertia compared to the conventional grid with synchronous generators, the microgrid is unable to address the frequency change issues resulting from the integration of large‐scale distributed generation. Due to the ability to provide virtual inertia, generalized droop control (GDC) and virtual synchronous generator (VSG) control are considered effective solutions for improving frequency regulation. However, in response to external frequency disturbances, the grid‐connected inverters may experience a significant transient active power overshoot caused by GDC and VSG. In this paper, the GDC is used as the fundamental control architecture, and then the small signal models of the GDC and VSG are compared and analyzed under various disturbances. A reduced‐order method for the GDC model is proposed to simplify the analysis of GDC. Additionally, GDC adaptive inertia (GDCAI) and adaptive inertia for operation mode switching (AIOMS) are proposed to mitigate frequency fluctuations and improve active power response. The effectiveness of the two control strategies is verified by MATLAB/Simulink simulation and StarSim hardware‐in‐the‐loop (HIL) experiment.
A Novel Common‐Ground Switched‐Capacitor Type Dual‐Mode Five‐Level Transformer‐Less Multilevel Inverter
Authors: Khan Saniya , Sarwar Adil , Zaid Mohammad , Ahmad Shafiq 
Published: November 2024

ABSTRACTThis paper presents a novel single‐source common‐ground switched‐capacitor (CGSC) type dual‐mode five‐level (5L) transformer‐less (TL) multilevel inverter (MLI) topology with inherent boosting capability. The proposed topology comprises a single DC source, nine power switches, and two capacitors with self‐voltage balancing ability, reducing the inverter's size, cost, and complexity. The direct connection of the negative terminal of the source to the neutral point of the load eliminates the leakage current. The converter can operate in both buck and boost mode based on the series–parallel switching conversion of the involved switches. The circuit description, control strategy, and design guidelines are discussed in detail. The steady‐state and dynamic performance of the proposed circuit is validated using MATLAB Simulink software. Reliability analysis of the proposed converter is done in detail. Furthermore, the proposed converter is being compared with state‐of‐the‐art topologies.
Cationic lipid transfection induces nuclear actin filaments
Authors: Sinha Molika , Fernandez Maria Kristha , Renz Malte 
Published: November 2024

AbstractCationic lipids are widely used for gene delivery. Here, we report the transient formation of nuclear actin filaments in mammalian cells transfected with commercially available transfection reagents regardless of the proteins transfected. Readily detectable with phalloidin, nuclear actin ranges from short filaments to a fully developed network. Nuclear actin filaments persist for hours, peak 20 h after transfection, and may be involved in DNA damage repair.
KLF2 Inhibits Ferroptosis and Improves Mitochondrial Dysfunction in Chondrocyte Through SIRT1/GPX4 Signaling to Improve Osteoarthritis
Authors: Shi Jiaqi , Chen Li , Wang Xu , Ma Xin 
Published: November 2024

ABSTRACTOsteoarthritis (OA), a disease of articular joints, is the leading cause of disability in the elderly. Repressing ferroptosis and improving mitochondrial function can delay the progression of OA. Kruppel‐like factor 2 (KLF2) exerts a protective effect on OA. However, whether KLF2 affects ferroptosis and mitochondrial function during OA remains unknown. The OA in vivo and in vitro models were constructed in this work. The structural damage of knee joint in OA mice was evaluated through Micro‐CT scanning. H&E, SOFG, TB, and TUNEL staining were applied for pathological examination of cartilage tissues. ELISA was employed to examine the contents of inflammatory factors. Additionally, iron deposition in cartilage tissues was measured by Prussian blue staining, and the levels of proteins related to ferroptosis were assessed by immunoblotting. Besides, mitochondrial morphology and function were estimated using a transmission electron microscope and JC‐1 staining. In interleukin (IL)‐1β‐treated C28/I2 cells, the levels of inflammatory factors, intracellular ROS, mitochondrial ROS, lipid ROS, and Fe2+ were measured. Mitochondrial function was evaluated by detecting the levels of mitochondrial membrane potential (MMP), ATP, mPTP, and OCR. KLF2 overexpression ameliorated the structural damage of knee cartilage in OA mice. KLF2 upregulation inhibited ferroptosis and alleviated mitochondrial damage in knee cartilage of OA mice and IL‐1β‐treated C28/I2 cells. Moreover, KLF2 overexpression activated SIRT1/GPX4 signaling in vivo and in vitro. EX527 addition blocked the influences of KLF2 upregulation on ferroptosis and mitochondrial dysfunction in IL‐1β‐treated C28/I2 cells. Altogether KLF2 inhibits ferroptosis and improves mitochondrial dysfunction in chondrocytes through SIRT1/GPX4 signaling to improve OA.
Examining Multi‐Sector Women‐Only Leadership Development Programmes: A Scoping Review of Recruitment Processes, Design and Instruction Methods, Content and Outcomes
Authors: Sayers‐Brown Rob , Beauregard T. Alexandra , Lewis Rachel , Yarker Joanna 
Published: November 2024

ABSTRACTOrganisations are recognising that more needs to be done to support female talent. One response to this is women‐only leadership development programmes (WLDPs). To date, no scoping review has previously been conducted to examine the design and outcomes of these programmes. The purpose of the present review was therefore to bring together current knowledge of these interventions. In June 2022, a scoping review of the academic literature was performed using Business Source Premier (EBSCO), PsycINFO and SCOPUS, resulting in 13 articles meeting the inclusion criteria. Findings indicate encouraging signs that these programmes support women's development through incorporating intersectionality and positive psychology theories, as well as curricula on networking, conflict management and career planning. Whilst the specifics about the design and delivered content of these theories are unclear, their inclusion appears to lead participants in the reviewed WLDPs to report increased self‐awareness, clarity of purpose and enhanced feelings of authenticity. This review also raises questions regarding the rigour of the selection methods by which participants are given access to the programmes, and the transparent reporting of the design and delivery methodologies. Further, research directions and implications for both theory and practice are provided.
Visual Implicit Pre‐Cueing Improves Response Time in Decision‐Making in Dyslexic Children
Authors: Barela José A. , da Silva Crislaine , de Jesus Paola R. , Figueiredo Gabriella A. , Barela Ana Maria F. , Novak Andrew R. , Fransen Job 
Published: November 2024

ABSTRACTThis study aimed to examine the effect of visual pre‐cueing presented at different time intervals in the response time of dyslexic and non‐dyslexic children. Fifteen dyslexic and 15 non‐dyslexic children performed a computerised four‐choice reaction time task across four conditions: no pre‐cue and a 43‐ms time interval (or duration) of a centralised dot appearing in the stimulus circle at 43, 86 or 129 ms prior to the stimulus. Each condition was repeated eight times, totaling 32 trials, and presented in a random order. Response correctness and response times were recorded for each trial, and z‐scores were obtained by standardising performance in the three pre‐cued conditions relative to the no pre‐cue condition. Dyslexic children took longer to respond in the task than non‐dyslexic children. Both dyslexic and non‐dyslexic children had faster response times in the pre‐cued conditions than in the conditions without the pre‐cue. These lower response times were inversely correlated with the length of the pre‐cueing interval. These results suggest that dyslexic children use visual pre‐cueing to improve decision‐making. The ability of dyslexic children to use pre‐cues may offer an interesting avenue for the exploration of interventions aimed at minimising behavioural and cognitive difficulties resulting from dyslexia.
Climate, predation, and the controls of island lizard abundance and community structure
Authors: Folfas Edita , Mahler D. Luke , Frishkoff Luke O. 
Published: November 2024

AbstractAlternative ecological theories make divergent predictions about the relationship between predators and their prey. If predators exert top‐down ecosystem control, increases in predation should diminish prey abundance and could either diminish or enhance community diversity of prey species. However, if bottom‐up ecosystem controls predominate, predator populations should track underlying variation in prey diversity and abundance, which ultimately should reflect available energy. Past research, both across islands and comparing islands with the mainland, has frequently invoked the importance of predation in regulating lizard abundance and diversity, suggesting an important role of top‐down control when predators are present. However, others have posited a stronger role of food limitation, via competition or bottom‐up forces. If top‐down control predominates, then negative correlations between prey abundance and predator occurrence should emerge within and among islands. Using data from eBird, we inferred landscape‐level presence data for bird species on the islands of Jamaica and Hispaniola. By summing occurrence probabilities of all known anole‐predator birds, we estimated total avian predation pressure and combined these estimates with anole community data from a mark‐recapture study that spanned spatial and climatic gradients on both islands. Avian predators and anole lizards were both affected by climate, with total predator occurrence, anole abundance and anole species richness increasing with mean annual temperature. Anole abundance and predator occurrence showed a curvilinear relationship, where abundance and predator occurrence increased together until predator occurrence became sufficiently high that anole abundance was negatively impacted. This indicates that bottom‐up ecosystem controls drive richness of both anoles and their predators, mitigating the negative effects predators might have on their prey, at least until predator occurrence reaches a threshold. We did not detect consistent evidence of predator occurrence reducing anole community richness. These findings support past research showing that islands with more predators tend to have lower prey abundances, but it does not seem that these top‐down forces are strongly limiting species coexistence. Instead, bottom‐up forces linked with climate may be more important drivers of diversity in both lizards and their avian predators on these islands.
Liana versus tree seedling responses to spatial and temporal variation in dry season severity
Authors: Estrada‐Villegas Sergio , Browne Luke , Manzané‐Pinzón Eric , Comita Liza S. 
Published: November 2024

AbstractLianas are key components of tropical forests, particularly at sites with more severe dry seasons. In contrast, trees are more abundant and speciose in wetter areas. The seasonal growth advantage (SGA) hypothesis postulates that such contrasting distributions are produced by higher liana growth relative to trees during seasonal droughts. The SGA has been investigated for larger size classes (e.g., ≥5 cm diameter at 1.3 m, dbh), but rarely for seedlings. Using eight annual censuses of >12,000 seedlings of 483 tree and liana species conducted at eight 1‐ha plots spanning a strong rainfall gradient in central Panama, we evaluated whether liana seedlings had higher growth and/or survival rates than tree seedlings at sites with stronger droughts. We also tested whether an extreme El Niño drought during the study period had a more negative effect on tree compared to liana seedlings. The absolute density of liana seedlings was similar across the rainfall gradient, ranging from 0.32 individuals/m2 (0.20–0.49, 95% credible interval [CI]) at the driest end of the gradient and 0.27 individuals/m2 (0.13–0.51 95% CI) at the wettest end of the gradient. The relative density of liana seedlings compared to tree seedlings was higher at sites with stronger dry seasons (0.27, 0.21–0.33, 95% CI), compared to wetter sites (0.12, 0.04–0.20 95% CI), due to lower tree seedling densities at drier sites. However, liana seedlings did not grow or survive better than tree seedlings in drier sites compared to wetter sites. Tree seedlings were more negatively impacted in terms of mortality by the extreme El Niño drought than liana seedlings, with an increase in annual mortality rate of 0.013 (0.003–0.025 95% CI) compared to lianas of −0.009 (−0.028 to 0.008 95% CI), but not growth. Our results indicate that lianas do not have a SGA over trees at the seedling stage. Instead, higher survival of liana versus tree seedlings during severe droughts or differences in liana versus tree fecundity or germination across the rainfall gradient likely explain why liana seedlings have higher relative densities at drier sites.
Interventional therapies for chronic heart failure: An overview of recent developments
Authors: Guo Bingchen , Shi Si , Guo Yutong , Xiong Jie , Wang Bo , Dong Zengxiang , Gao Dianyu , Tu Yingfeng 
Published: November 2024

AbstractHeart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the prognosis of patients with HF. These advancements include transcatheter aortic valve replacement for severe aortic stenosis, transcatheter mitral valve repair for chronic mitral regurgitation, neuromodulation therapy for multiple targets and measures in the treatment of chronic HF and left ventricular assist device implantation for advanced HF (Figure 1). In this review, we aimed to provide an overview of the current progress in interventional therapies for chronic HF.