bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing Potentially Preventable Cancer- and Chronic Disease–Related Emergency Department Use in the Year After Treatment Initiation: A Regional Study
Authors: Panattoni Laura , Fedorenko Catherine , Greenwood-Hickman Mikael Anne , Kreizenbeck Karma , Walker Julia R. , Martins Renato , Eaton Keith D. , Rieke John W. , Conklin Ted , Smith Bruce , Lyman Gary , Ramsey Scott D. 
Published: February 2018

Purpose: As new quality metrics and interventions for potentially preventable emergency department (ED) visits are implemented, we sought to compare methods for evaluating the prevalence and costs of potentially preventable ED visits that were related to cancer and chronic disease among a commercially insured oncology population in the year after treatment initiation. Methods: We linked SEER records in western Washington from 2011 to 2016 with claims from two commercial insurers. The study included patients who were diagnosed with a solid tumor and tracked ED utilization for 1 year after the start of chemotherapy or radiation. Cancer symptoms from the Centers for Medicare & Medicaid Services metric and a patient-reported outcome intervention were labeled potentially preventable (PpCancer). Prevention Quality Indicators of the Agency for Healthcare Research and Quality were labeled potentially preventable–chronic disease (PpChronic). We reported the primary diagnosis, all diagnosis field coding (1 to 10), and 2016 adjusted reimbursements. Results: Of 5,853 eligible patients, 27% had at least one ED visit, which yielded 2,400 total visits. Using primary diagnosis coding, 49.8% of ED visits had a PpCancer diagnosis, whereas 3.2% had a PpChronic diagnosis. Considering all diagnosis fields, 45.0%, 9.4%, and 18.5% included a PpCancer only, a PpChronic only, and both a PpCancer and a PpChronic diagnosis, respectively. The median reimbursement per visit was $735 (interquartile ratio, $194 to $1,549). Conclusion: The prevalence of potentially preventable ED visits was generally high, but varied depending on the diagnosis code fields and the group of codes considered. Future research is needed to understand the complex landscape of potentially preventable ED visits and measures to improve value in cancer care delivery.
Matchmaking in Bioinformatics
Authors: Mathé Ewy , Busby Ben , Piontkivska Helen ,   Team of Developers
Published: February 2018

Ever return from a meeting feeling elated by all those exciting talks, yet unsure how all those presented glamorous and/or exciting tools can be useful in your research? Or do you have a great piece of software you want to share, yet only a handful of people visited your poster? We have all been there, and that is why we organized the Matchmaking for Computational and Experimental Biologists Session at the latest ISCB/GLBIO’2017 meeting in Chicago (May 15-17, 2017). The session exemplifies a novel approach, mimicking “matchmaking”, to encouraging communication, making connections and fostering collaborations between computational and non-computational biologists. More specifically, the session facilitates face-to-face communication between researchers with similar or differing research interests, which we feel are critical for promoting productive discussions and collaborations. To accomplish this, three short scheduled talks were delivered, focusing on RNA-seq, integration of clinical and genomic data, and chromatin accessibility analyses. Next, small-table developer-led discussions, modeled after speed-dating, enabled each developer (including the speakers) to introduce a specific tool and to engage potential users or other developers around the table. Notably, we asked the audience whether any other tool developers would want to showcase their tool and we thus added four developers as moderators of these small-table discussions. Given the positive feedback from the tool developers, we feel that this type of session is an effective approach for promoting valuable scientific discussion, and is particularly helpful in the context of conferences where the number of participants and activities could hamper such interactions.
Nurse-run clinic for functional bowel disorders at a district general hospital
Authors: Khan Usman , Basrai Samrait , Lewis Maria , Haray Puthucode 
Published: February 2018

Background: Functional bowel disorders (FBDs) include constipation, diarrhoea, bloating and unspecified FBD. FBDs have serious symptoms that impact quality of life and require effective resource management to reduce their impact on clinical services. Aim: The experience of a nurse-led FBD service in a UK district general hospital is presented. The service is protocol driven and led by a colorectal clinical nurse specialist (CNS), with appropriate consultant supervision. Referrals are from primary care and consultant clinicians. Method: Demographics, investigations, treatments and outcomes were analysed using a prospectively run database of the clinic's patients from 2005 to 2016. Results: There were records of 980 patients (median age 56 years; 115M:865F); 60.1% had diarrhoea alone, 36.5% had constipation alone and 3.4% had both. Investigations included barium enema, endoanal ultrasound and transit study. Treatments included rectal irrigation (59.7%), laxative (53.2%), enema (12.3%), anti-diarrhoeal (6%), bowel training (2.4%) or another drug (1.8%). Conservative management was successful in most patients, and only 83 (8.4%) patients were referred for surgery. Conclusion: The nurse-led service is safe, effective and has good outcomes, with a low surgery conversion and high patient satisfaction.
Cost-effectiveness of using a collagen-containing dressing plus compression therapy in non-healing venous leg ulcers
Authors: Guest Julian F. , Rana Karan , Singh Heenal , Vowden Peter 
Published: February 2018

Objective: To estimate whether collagen-containing dressings could potentially afford the UK's National Health Service (NHS) a cost-effective intervention for the management of non-healing venous leg ulcers (VLUs). Method: This was a modelling study performed from the perspective of the UK's NHS. A combination of published clinical outcomes, resource utilisation estimates and utilities for VLUs enabled the construction of a decision model, depicting the management of a chronic VLU with standard care or with a collagen-containing dressing plus compression therapy followed by standard care, over a period of 6 months. The model estimated the incremental cost-effectiveness of the two interventions in terms of the incremental cost per quality-adjusted life year (QALY) gained at 2015/16 prices. Results: The treatment of VLUs of >6 months' duration with a collagen-containing dressing plus compression therapy followed by standard care, instead of standard care, is expected to increase the probability of healing from 0.11 to 0.49 by 6 months and increase health-related quality of life at 6 months from 0.331 to 0.373 QALYs per patient. Additionally, treatment with a collagen-containing dressing plus compression therapy followed by standard care has the potential to reduce management costs by 40% over 6 months when compared with standard care (from £6328 to £3789 per patient). Conclusion: Within the study's limitations, including a collagen-containing dressing into a standard care protocol compared with standard care potentially affords the NHS a cost-effective (dominant) treatment since it improves outcomes for less cost.
Designs and performance of three new microprocessor-controlled knee joints
Authors: Thiele Julius , Schöllig Christina , Bellmann Malte , Kraft Marc 
Published: February 2018

Abstract
A crossover design study with a small group of subjects was used to evaluate the performance of three microprocessor-controlled exoprosthetic knee joints (MPKs): C-Leg 4, Plié 3 and Rheo Knee 3. Given that the mechanical designs and control algorithms of the joints determine the user outcome, the influence of these inherent differences on the functional characteristics was investigated in this study. The knee joints were evaluated during level-ground walking at different velocities in a motion analysis laboratory. Additionally, technical analyses using patents, technical documentations and X-ray computed tomography (CT) for each knee joint were performed. The technical analyses showed that only C-Leg 4 and Rheo Knee 3 allow microprocessor-controlled adaptation of the joint resistances for different gait velocities. Furthermore, Plié 3 is not able to provide stance extension damping. The biomechanical results showed that only if a knee joint adapts flexion and extension resistances by the microprocessor all known advantages of MPKs can become apparent. But not all users may benefit from the examined functions: e.g. a good accommodation to fast walking speeds or comfortable stance phase flexion. Hence, a detailed comparison of user demands and performance of the designated knee joint is mandatory to ensure a maximum in user outcome.
Approaches for calibration and validation of near-infrared optical methods for oxygenation monitoring
Authors: Hornberger Christoph , Wabnitz Heidrun 
Published: February 2018

Abstract
Pulse oximetry for arterial oxygenation monitoring and tissue oximetry for monitoring of cerebral oxygenation or muscle oxygenation are based on quantitative in vivo diffuse optical spectroscopy. However, in both cases the information on absolute or relative concentration of human tissue constituents and especially on hemoglobin oxygenation can often not be retrieved by model-based analysis. An in vivo calibration against an accepted reference measurement can be a practical alternative. Pulse oximeters and most of commercial cerebral tissue oximeters rely on empirical calibration based on invasive controlled human desaturation studies. As invasive in vivo tests on healthy subjects are ethically disputable and should be limited to exceptional cases this calibration practice is unsatisfactory. We present the current status and problems of calibration and validation in pulse oximetry and cerebral tissue oximetry including the pros and cons of in vivo as well as in vitro methods. We emphasize various digital and physical phantom approaches and discuss the prospects of their application and possible further developments.
Re-creating the engagement in managerial learning
Authors: Gatarik Eva , Born Rainer 
Published: February 2018

Abstract
When defending his doctoral dissertation, Umberto Eco was accused of narrative fallacy because he presented his research as if it were a detective novel. He should have presented only his conclusions. However, this criticism inspired Eco to claim that “[e]very scientific book should be ... the report of a quest for some Holy Grail” (Eco, 2011, p. 7). A quest presupposes engagement on both sides of the knowledge exchange. Building upon our own research, we have produced a model-theoretic scheme for management studies in support of the practicability of Eco’s claim. The idea is to re-create the engagement when establishing problem-solving competence in managerial learning: We start with an analysis of real-life cases of successful managerial problem solving (“best practices”). Next, we attempt to find the common denominator of those successful solutions. Lastly, we instantiate the principles found in the previous step in new problem situations, and thus provide new uses for them.
Slurs, truth-value judgements, and context sensitivity
Authors: Sileo Roberto B. 
Published: February 2018

Abstract
Cappelen and Lepore (2005) claim that the English language contains a basic and limited set of context-sensitive expressions, as only expressions within this set pass the truth-related tests that they propose to single out context-sensitive from context-insensitive words. In this paper, I argue that racial and ethnic slurs also pass Cappelen and Lepore’s context sensitivity tests and that, as a result, slurs should also be seen as context-sensitive expressions in a truth-related sense.
“It’s also a kind of adrenalin competition” – selected aspects of the sex trade as viewed by clients
Authors: Ondrášek Stanislav , Řimnáčová Zuzana , Kajanová Alena 
Published: February 2018

Abstract
The main goal of the article is to describe selected aspects of the sex trade as viewed by clients who make use of the services provided by sex workers. We use data obtained through a content analysis of selected topics discussed on an erotic forum called Nornik.net. The topics were: Can a person stop “screwing”?; what was your first contact with the sex trade and how can a person hide their visits to sex workers? In the course of the analysis, we identified an additional category that featured in all the topics: “trophy collecting”. The discussants perceive sex workers as a commodity to be purchased and subsequently evaluated. The discussants tended to compete among themselves to visit the most sex workers or to be first to visit the latest sex worker. The discussion forum serves as a support centre and contains hints and tips on different areas of “screwing” and related issues. The forum also displays certain features of a community.
Voices from altarpieces: Making sense of the sacred
Authors: Nežinská Emma 
Published: February 2018

Abstract
The article is a cultural-philosophical response to Ivan Gerát’s Legendary Scenes and his art history interpretation of the function of Slovak hagiographic pictorial art of the Late Middle Ages. The thrust is on paintings of Christian ethical extremism, reflected in the principle of imitatio Christi. It led to the deaths of martyrs and saints in the name of the Faith. The preponderance of brutal scenes involving the tortured human body in this period art is examined in detail and it is suggested that these portrayals are disincentives that put off the mass culture beholder. The contextualist art history method employed in Gerát’s book is gradually explored, along with its potential to transform the uninterested postmodern beholder into an intelligent beholder and art tourist. Attention is paid to the educational and national branding aspects of Legendary Scenes.
The EU English Terms Including the Word Market and Their French and Lithuanian Equivalents
Authors: Smirnova Oksana , Rackevičienė Sigita 
Published: February 2018

Summary
Translation of terminology is an essential factor and often a challenging task in the translation of legal acts. Various databases are available to facilitate the translation process and ensure its quality. The main inter-institutional terminology database of the European Union is IATE (“Inter Active Terminology for Europe”). The aim of the paper is to conduct a contrastive analysis of a group of English, French and Lithuanian economic terms based on the information provided in IATE. The object chosen for the research is the English, Lithuanian and French multi-word terms including the word market. In total, 266 terms were collected from IATE: 90 English terms and their equivalents in French and Lithuanian. The paper presents a classification of the terms into semantic categories according to various aspects of markets (object of the market, place of the market, duration of the market availability, degree and nature of competition among the market participants, production stage of the items offered in the market, etc.), compares the formal structure of the English terms and their French and Lithuanian equivalents and reveals the tendencies of term formation in the investigated languages. Finally, the paper discusses the problem of synonymy of the terms and the data provided in the term entries of IATE.
CLIL Teacher Competences and Attitudes
Authors: Vilkancienė Lilija , Rozgienė Inga 
Published: February 2018

SummaryThe paper presents the findings of the research carried out among the participants of the project ”Development of Content and Language Integrated Learning (CLIL) in Education” (2011-2013) that aimed to upgrade the competences of subject teachers enabling them to implement content and foreign language integrated learning approach in general education and vocational training. The data obtained through a survey indicates that the project participants developed a positive attitude towards the CLIL approach and positively assess the competences acquired during the programme. European Framework for CLIL Teacher Education proves to be a useful tool when designing training courses for specific target groups of qualified content teachers and a fifty hours' programme seems to be adequate to get acquainted with the fundamentals of CLIL. The project participants were most positive about their CLIL methodology competence development during the project and ability to identify appropriate subject content for teaching by using the CLIL approach. The weakest point identified by the participants involves languagerelated issues, such as ability to support language learning in content, balancing the target language used between the learners' and teacher's linguistic ability, and overall insufficiency of linguistic competences. One more issue indicated by the respondents is the absence of standards, guidance and administrative support, as well as quality assurance (content delivery, materials and assessment) in CLIL.
Adult female with symptomatic AVPR2-related nephrogenic syndrome of inappropriate antidiuresis (NSIAD)
Authors: Hague Jennifer , Casey Ruth , Bruty Jonathan , Legerton Tom , Abbs Stephen , Oddy Susan , Powlson Andrew S , Majeed Mohamed , Gurnell Mark , Park Soo-Mi , Simpson Helen 
Published: February 2018

Summary
Activating mutations in AVPR2 are associated with nephrogenic syndrome of inappropriate antidiuresis (NSIAD). NSIAD causes hyponatremia, decreased serum osmolality and clinical symptoms, which may present from birth or in infancy and include hypotonia, irritability, vomiting and/or seizures. Symptoms in later life are often less specific and include malaise, dizziness, confusion, tiredness and headache. NSIAD is a rare X-linked condition, which is associated with a variable phenotype in males, of whom some present in infancy but others do not become symptomatic until adulthood, or occasionally, never. Female carriers may present with episodes of hyponatremia, usually found incidentally. Literature in this field is limited; namely, two clinical reports describing a female proband, both diagnosed in infancy. We describe, for the first time, the case of an adult female proband with NSIAD, who had longstanding associated symptoms of tiredness, headache, temporary memory loss and mood changes as well as hyponatremia and decreased serum osmolality. A water load test demonstrated an inability to dilute urine and gene sequencing confirmed a recurrent activating mutation in AVPR2. The variant was inherited from the proband’s mother who had had longstanding episodes of transient asymptomatic hyponatremia. This is the third report of a female proband with NSIAD and is the first female reported who sought medical treatment for chronic symptoms from adulthood. This case acts as a reminder of the importance of considering NSIAD as a diagnosis in females of all ages with unexplained hyponatremia.

Learning points:

Activating mutations in the AVPR2 gene are associated with the rare X-linked condition nephrogenic syndrome of inappropriate antidiuresis.

NSIAD is associated with hyponatremia, decreased serum osmolality and inappropriately increased urinary osmolality. Early clinical symptoms in infancy include hypotonia, irritability, vomiting and/or seizures. Symptoms in later life include malaise, dizziness, confusion, tiredness and headache.

NSIAD should be considered in female, as well as male, patients who present with unexplained hyponatremia and decreased serum osmolality. Family history may reveal relevant symptoms or biochemical features in other family members. However, family history may not always be informative due to the variable nature of the condition or if the proband has a de novo pathogenic variant.
A water load test with measurement of AVP may be informative in distinguishing NSIAD from SIADH. Measurement of co-peptin levels may be considered, in substitution for direct measurement of AVP.

Patients with NSIAD should be counseled about appropriate daily fluid volume intake. Potential episodes of fluid overload should be avoided.
Desarrollo embrionario preimplantacional, en ciclos de fecundación in vitro con ovodonación y estudio genético
Authors: Villanueva Pamela , Portella Jimmy , López Rosmary , Chávez Nathaly , Villalobos Amalia , Noriega-Hoces Luis , Guzmán Luis 
Published: February 2018

Introducción. Los estudios genéticos preimplantacionales son cada vez más utilizados con la esperanza de conseguir mejores tasas de implantación y nacido vivo, así como una disminución en la tasa de abortos; por ello resulta necesario analizar estos procedimientos. Objetivo. Evaluar el desarrollo preimplantacional in vitro con ovodonación y estudio genético Diseño. Cohortes retrospectivas. Lugar. Laboratorio Pranor, 2008-2013. Material. Ciclos de fecundación in vitro con ovodonación (FIV-OD). Intervenciones. Se evaluaron 2 077 ciclos de FIV-OD, los cuales fueron clasificados en tres cohortes: 1) ciclos con biopsia embrionaria en día 3, mediante una incisión en la zona pelúcida (ZP) embrionaria, para exéresis de una blastómera (n=527); 2) ciclos con incisión láser en día 4 del desarrollo embrionario, como parte del procedimiento para la biopsia de trofoblasto (n=131); y, 3) ciclos sin intervención (n=1 419). Principales medidas de resultado. Tasa de fecundación, tasa de blastulación. Resultados. No existió diferencia significativa en la tasa de fecundación de las 3 cohortes (75,0%, 74,6% y 75,9%, respectivamente, p=0,31). La tasa de blastulación en la cohorte 1 fue 42,5%, mientras que en la cohorte 3 fue 47% (RR=1,085; IC=1,051 a 1,120; p<0,0001). Adicionalmente, la cohorte 2 tuvo 51,9%, con una diferencia estadísticamente significativa de prevención del riesgo de no blastular con respecto a la cohorte 3 (RR=0,906; IC=0,851 a -0,965; p=0,0017). Conclusiones. El desarrollo preimplantacional hasta blastocisto puede mejorar cuando se utiliza el láser embrionario en día cuatro. Es necesario realizar más estudios para confirmar nuestros resultados.
Inhaled Nitric Oxide in Extremely Premature Neonates With Respiratory Distress Syndrome
Authors: Carey William A. , Weaver Amy L. , Mara Kristin C. , Clark Reese H. 
Published: February 2018

BACKGROUND:
Inhaled nitric oxide (iNO) is increasingly prescribed to extremely premature neonates with respiratory distress syndrome (RDS). Most of this off-label use occurs during the first week of life. We studied this practice, hypothesizing that it would not be associated with improved survival.

METHODS:
We queried the Pediatrix Medical Group Clinical Data Warehouse to identify all neonates born at 22 to 29 weeks’ gestation from 2004 to 2014. In our study sample, we included singletons who required mechanical ventilation for treatment of RDS and excluded those with anomalies. The primary outcome was death before discharge. Through a sequential risk set approach, each patient who received iNO during the first 7 days of life (“case patient”) was matched by using propensity scores to a patient who had not received iNO at a chronological age before the case patient’s iNO initiation age (defined as the index age for the matched pair). The association between iNO status and in-hospital mortality was evaluated in a Cox proportional hazards regression model by using age as the time scale with patients entering the risk set at their respective index age.

RESULTS:
Among 37 909 neonates in our study sample, we identified 993 (2.6%) who received iNO. The 2 matched cohorts each contained 971 patients. We did not observe a significant association between iNO exposure and mortality (hazard ratio, 1.08; 95% confidence interval, 0.94–1.25; P = .29).

CONCLUSIONS:
Off-label prescription of iNO is not associated with reduced in-hospital mortality among extremely premature neonates with RDS.