bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overall survival of patients with EGFR mutation-positive non-small-cell lung cancer treated with erlotinib, gefitinib or afatinib under drug programmes in Poland – Real-World Data
Authors: Brzozowska Melania , Wierzba Waldemar , Szafraniec-Buryło Sylwia , Czech Marcin , Majkut Gabriela , Połowinczak-Przybyłek Joanna , Potemski Piotr , Śliwczyński Andrzej 
Published: February 2019

IntroductionThe aim of the study was to estimate the overall survival of patients with EGFR mutation-positive non-small-cell lung cancer treated with erlotinib, gefitinib or afatinib.Material and methodsReal-world patients who received afatinib, erlotinib or gefitinib between 1 July 2012 and 30 October 2017 were analysed in five subgroups.ResultsAmong 267 patients treated with afatinib financed as the first line of treatment, 76 (28.46%) deaths occurred. Median observation time was 12.8 months (95% CI: 11.2–13.9). Median OS was 22.8 months (95% CI: 19.2–27.1). Among 83 patients who received erlotinib financed exclusively as the second line of treatment the number of deaths was 74 (89.16%). Median observation time was 64.3 months (95% CI: 60.4–64.6). Median OS was 16 months (95% CI: 13.2–22.9). Among 622 patients who received erlotinib financed both as first and second line treatment, there were 400 (64.3%) deaths. Median observation time was 33.3 months (95% CI: 31.2–37.6). Median OS was 17.8 months (95% CI: 16.4–19.7). Among 137 patients who received gefitinib financed only as the first line of treatment, there were 128 (93.4%) deaths. Median observation time was 58.3 months (95% CI: 49.4–62.5). Median OS was 16 months (95% CI: 13.8–19.7). Among 348 patients who received gefitinib financed both as the first and second line of treatment the number of deaths was 208 (59.8%). Median observation time was 23.7 months (95% CI: 20.7–28.7). Median OS was 15.5 months (95% CI: 12.9–17.5).ConclusionsOur real-world data regarding OS confirm the benefits found in clinical trials from the use of afatinib, erlotinib or gefitinib. However, the lower overall survival rate of Polish patients compared to similar studies from other research centres suggests the need for deeper investigation of this issue.
The role of vitamin D in perinatology. An up-to-date
review
Authors: Ciebiera Michał , Wojtyła Cezary , Łukaszuk Krzysztof , Zgliczyńska Magdalena , Zaręba Kornelia , Rawski Wojciech , Jakiel Grzegorz 
Published: February 2019

The role of vitamin D in perinatology is a subject of major interest in current medicine. There is growing evidence about the role of maternal vitamin D levels in pregnancy outcomes. The aim of this review is to summarize the current literature about the role of vitamin D in perinatology. Evidence from this review suggests associations between low levels of maternal vitamin D and higher risk of certain obstetrical complications. Vitamin D has been found to be related to preeclampsia, gestational diabetes mellitus, low birth weight, and preterm birth. The current literature supports vitamin D supplementation in pregnant women, but more high-quality data are necessary. The problem that remains is how to achieve an optimal 25-hydroxyvitamin D level. To determine the real benefits of vitamin D supplementation in pregnancy, we need high-quality trials in larger groups.
Vitamin D receptor gene polymorphisms and uterine fibroid incidence in Caucasian women
Authors: Ciebiera Michał , Wrzosek Małgorzata , Wojtyła Cezary , Zaręba Kornelia , Nowicka Grażyna , Jakiel Grzegorz , Włodarczyk Marta 
Published: February 2019

IntroductionUterine fibroids (UFs) are benign tumors which are derived from the smooth muscle cells of the uterus. Recent studies have demonstrated that the development of UFs can be particularly related to vitamin D and its receptor. Vitamin D comprises a group of fat-soluble steroid compounds which exert powerful, pleiotropic effects all over the human body. These actions are mediated by a specific type of receptor – vitamin D receptor (VDR). Recent findings have focused on the possible role of VDR genetic variations in the development of several types of diseases, e.g. autoimmune system diseases, various cancers and infections.Material and methodsThe aim of the study was to evaluate the association between rs731236, rs1544410, and rs2228570 polymorphisms in the VDR (vitamin D receptor) gene and the incidence of UFs in Caucasian women. A total of 197 patients (114 fibroid-positive and 83 controls) were included in this retrospective cohort study. VDR gene polymorphisms rs731236 (TaqI), rs1544410 (BsmI) and rs2228570 (FokI) were determined using TaqMan and Simple Probes.ResultsNo statistically significant differences in the occurrence of selected VDR polymorphisms were observed between UF-positive women and healthy controls.ConclusionsWe found no association between rs731236, rs1544410, and rs2228570 VDR polymorphisms and UF incidence in Caucasian women. Larger sample size and multi-ethnic studies are necessary to investigate the matter further.
Interval Hysterectomy for Placenta Percreta – a Case Report
Authors: Huque Mohammad Sazzadul , Ravi Mini 
Published: February 2019

Introduction: Placenta percreta is an abnormality of placentation where it invades the serosa and can go beyond it. Complications include massive hemorrhage, bladder dysfunction, and severe infections during delivery. The aim of this study is to report a complex case of placenta percreta managed by interval hysterectomy.Case presentation: Pre-operative: 34 years old patient with previous three cesarean sections was followed in antenatal clinic. She came with repeated bouts of vaginal bleeding at 30-31 weeks. At 32 weeks and 4 days classical cesarean section was done with placenta left in situ. Prophylactic bilateral internal iliac artery balloon was inserted. Post cesarean section, uterine artery embolization was performed. Post-operative: Clinical features of pulmonary embolism (PE) developed about 4 hours later. Post-Operative Day 13: Total abdominal hysterectomy was done. After few days of discharge, the patient presented to the emergency department with shortness of breath. She was consequently diagnosed with chronic pulmonary embolism and treated with warfarin.Conclusion: This is a case of placenta percreta managed by interval hysterectomy. However, the most widely accepted method of management is cesarean hysterectomy. In this case, interval hysterectomy was done due to the possibility of bladder invasion by placenta, to decrease the amount of blood loss and to reduce the number of days stayed in hospital. Appropriate management for the patient must be personalized, whether it is by cesarean hysterectomy or interval hysterectomy, as each has risks and benefits.
Introduction to a Review Symposium on Jayeel S. Cornelio&#x92;s Being Catholic in the Contemporary Philippines (2016)
Authors: Hermann Adrian 
Published: February 2019

ABSTRACT
This article introduces a review symposium on Jayeel Serrano Cornelio&#x92;s 2016 book Being Catholic in the Contemporary Philippines: Young People Reinterpreting Religion. It presents the four contributions to the review symposium as well as Cornelio&#x92;s response and relates the discussion of the book to the broader necessity of developing new perspectives on religion in the Philippines.
Global Entanglements, Essentialist Understandings of Religion, and Agency in the Study of Contemporary Catholicism
Authors: Maltese Giovanni 
Published: February 2019

ABSTRACT
The article discusses theoretical and methodological problems in the study of contemporary Catholicism. In critical engagement with Jayeel S. Cornelio&#x92;s book Being Catholic in the Contemporary Philippines on young people reinterpreting religion in the Philippines, I discuss shortcomings related to questions of power, agency, and essentialist understandings of the subject matter. I argue that a global history and cultural studies&#x96;informed approach, which draws on poststructuralist theory and takes hegemonic struggles seriously, is best equipped to investigate religion and identity-making among Catholic youths in the Philippines and beyond.
Ship Roll Damping Coefficient Prediction Using CFD
Authors: Kianejad Seyed Sadra , Enshaei Hossein , Duffy Jonathan , Ansarifard Nazanin , Ranmuthugala Dev 
Published: February 2019

For a ship undergoing roll motion at a resonance frequency, the roll restoring moment and virtual moment of inertia counteract each other and only the damping moment resists the roll exciting moments. Hence, accurate computation of the roll damping moment improves the roll motion prediction. There are several methods to calculate the damping moment; however, most of them fail to consider the viscous effects, such as the potential theory-based method. The experimental measurements take into account the viscous effect; however, they are expensive. The Computational Fluid Dynamics (CFD) method is an alternative to accurately consider the viscous effect. In this study, a CFD approach based on harmonic exciting roll motion technique is adopted to compute the roll motion characteristics and damping coefficients at different conditions. The impact of appendages, Froude number, and degrees of freedom on roll motion characteristics and damping coefficients are investigated for the model scale and full scale to study the scale effects. The results at the model scale are compared against experimental measurements and good correlation was found.

1. Introduction
Controlling the roll motion of a ship in a seaway is essential for the safety and habitability. The roll motion of a ship is nonlinear, and the nonlinearity increases at the resonance as the ship experiences larger roll motion. Accurately computing the roll damping at the resonance frequency is important because the moment of inertia and restoring moment counteract each other and the damping moment opposes the roll motion. The total roll damping consists of friction damping, body eddy shedding damping, surface wave damping, lift force damping, and appendages damping. The wave and lift force damping can be calculated by potential flow theory based methods, whereas others are influenced by viscosity.
In general, most roll damping calculation methods are based on empirical models, and Ikeda's method (Ikeda et al. 1978) is most common one. Although this method works quite well for conventional ships, the predicted results are sometimes conservative or underestimated for unconventional ships (Gu et al. 2013). Large roll damping is strongly nonlinear and is influenced by fluid viscosity and flow characteristics such as flow separation and vortex shedding. Empirical or semi-empirical methods cannot account the flow characteristics of such a complex flow. Roll damping calculation for conventional ships by Ikeda's simplified method can fit experimental data quite well at small roll angles. However, when the roll angle is large, it is out of the acceptable range of Ikeda's method, and the accuracy of the computed damping coefficient is low (Kawahara et al. 2012).
Highly Stretchable, High‐Mobility, Free‐Standing All‐Organic Transistors Modulated by Solid‐State Elastomer Electrolytes
Authors: Park Do Hyung , Park Han Wool , Chung Jong Won , Nam Kyungah , Choi Shinyoung , Chung Yoon Sun , Hwang Haejung , Kim BongSoo , Kim Do Hwan 
Published: February 2019

AbstractHighly stretchable, high‐mobility, and free‐standing coplanar‐type all‐organic transistors based on deformable solid‐state elastomer electrolytes are demonstrated using ionic thermoplastic polyurethane (i‐TPU), thereby showing high reliability under mechanical stimuli as well as low‐voltage operation. Unlike conventional ionic dielectrics, the i‐TPU electrolyte prepared herein has remarkable characteristics, i.e., a large specific capacitance of 5.5 µF cm−2, despite the low weight ratio (20 wt%) of the ionic liquid, high transparency, and even stretchability. These i‐TPU‐based organic transistors exhibit a mobility as high as 7.9 cm2 V−1 s−1, high bendability (Rc, radius of curvature: 7.2 mm), and good stretchability (60% tensile strain). Moreover, they are suitable for low‐voltage operation (VDS = −1.0 V, VGS = −2.5 V). In addition, the electrical characteristics such as mobility, on‐current, and threshold voltage are maintained even in the concave and convex bending state (bending tensile strain of ≈3.4%), respectively. Finally, free‐standing, fully stretchable, and semi‐transparent coplanar‐type all‐organic transistors can be fabricated by introducing a poly(3,4‐ethylenedioxythiophene):polystyrene sulfonic acid layer as source/drain and gate electrodes, thus achieving low‐voltage operation (VDS = −1.5 V, VGS = −2.5 V) and an even higher mobility of up to 17.8 cm2 V−1 s−1. Moreover, these devices withstand stretching up to 80% tensile strain.
Multifunctional Janus Microplates Arrays Actuated by Magnetic Fields for Water/Light Switches and Bio‐Inspired Assimilatory Coloration
Authors: Jiang Shaojun , Hu Yanlei , Wu Hao , Zhang Yachao , Zhang Yiyuan , Wang Yulong , Zhang Yinghui , Zhu Wulin , Li Jiawen , Wu Dong , Chu Jiaru 
Published: February 2019

AbstractSmart dynamic regulation structured surfaces, inspired by nature, which can dynamically change their surface topographies under external stimuli for convertible fluidic and optical properties, have recently motivated significant interest for scientific research and industrial applications. However, there is still high demand for the development of multifunctional dynamically transformable surfaces using facile preparation strategies. In this work, a type of Janus high‐aspect‐ratio magnetically responsive microplates array (HAR‐MMA) is readily fabricated by integrating a flexible laser scanning strategy, smart shape‐memory‐polymer‐based soft transfer, and a simple surface treatment. By applying external magnetic field, instantaneous and reversible deformation of Janus HAR‐MMA can be actuated, so surface wettability can be reversibly switched between superhydrophobic (158°) and hydrophilic (40°) states, based on which a novel magnetically responsive water droplet switch can be realized. Moreover, inspired by the biological assimilatory coloration of chameleons, dynamically color conversion can be skillfully realized by applying different colors on each side of the Janus HAR‐MMA. Finally, as a proof‐of‐concept demonstration in light manipulation, a HAR‐MMA is applied as an optical shutter actuated by external magnetic field with eximious controllability and repeatability. The developed multifunctional HAR‐MMA provides a versatile platform for microfluidic, biomedical, and optical applications.
Self‐Powered Intracellular Drug Delivery by a Biomechanical Energy‐Driven Triboelectric Nanogenerator
Authors: Liu Zhirong , Nie Jinhui , Miao Bin , Li Jiadong , Cui Yuanbo , Wang Shu , Zhang Xiaodi , Zhao Gengrui , Deng Yongbo , Wu Yihui , Li Zhou , Li Linlin , Wang Zhong Lin 
Published: February 2019

AbstractNondestructive, high‐efficiency, and on‐demand intracellular drug/biomacromolecule delivery for therapeutic purposes remains a great challenge. Herein, a biomechanical‐energy‐powered triboelectric nanogenerator (TENG)‐driven electroporation system is developed for intracellular drug delivery with high efficiency and minimal cell damage in vitro and in vivo. In the integrated system, a self‐powered TENG as a stable voltage pulse source triggers the increase of plasma membrane potential and membrane permeability. Cooperatively, the silicon nanoneedle‐array electrode minimizes cellular damage during electroporation via enhancing the localized electrical field at the nanoneedle–cell interface and also decreases plasma membrane fluidity for the enhancement of molecular influx. The integrated system achieves efficient delivery of exogenous materials (small molecules, macromolecules, and siRNA) into different types of cells, including hard‐to‐transfect primary cells, with delivery efficiency up to 90% and cell viability over 94%. Through simple finger friction or hand slapping of the wearable TENGs, it successfully realizes a transdermal biomolecule delivery with an over threefold depth enhancement in mice. This integrated and self‐powered system for active electroporation drug delivery shows great prospect for self‐tuning drug delivery and wearable medicine.
Observation of Crystalline Oxidized Silicon Phase
Authors: Kuzmin Mikhail , Lehtiö Juha‐Pekka , Mäkelä Jaakko , Yasir Muhammad , Rad Zahra Jahanshah , Vuorinen Esa , Lahti Antti , Punkkinen Marko , Laukkanen Pekka , Kokko Kalevi , Hedman Hannu‐Pekka , Punkkinen Risto , Lastusaari Mika , Repo Päivikki , Savin Hele 
Published: February 2019

AbstractSilica phases, SiOx forming at surfaces of various silicon crystals, e.g., Si wafers, nanowires, and nanoparticles via Si oxidation are key building blocks of diverse applications in the fields of electronics, medicine, and photonics for instance. The Si oxidation has been established to produce amorphous SiOx films, and the resulting oxide/silicon structures are prototypical junctions or contacts of amorphous and crystalline materials of which formation and properties have been extensively studied to understand and develop functionality of SiOx/Si in the applications. Here, observation of hitherto undiscovered phase of the SiOx/Si material, which is crystalline without traditional amorphous silica, is presented. The crystalline SiOx/Si structures are produced in vacuum environment via controlled oxidations of Si where O atoms are incorporated beneath the topmost Si layer. Concomitantly some Si atoms are detached from the crystal, and diffuse to the topmost surface, consistent with previous theoretical predictions, retaining still a pure Si‐surface type reconstruction and leading to a crystalline stack of Si/SiOx/Si. In addition to providing a well‐defined platform to studies of the SiOx/Si system, the found crystalline phase is also hypothesized to decrease amounts of disorder‐induced defects in the applications. Presented electrical characterization via carrier‐lifetime and capacitor measurements support the hypothesis.
Iron‐Catalysed Switchable Synthesis of Pyrrolidines vs Pyrrolidinones by Reductive Amination of Levulinic Acid Derivatives via Hydrosilylation
Authors: Wei Duo , Netkaew Chakkrit , Darcel Christophe 
Published: February 2019

AbstractA selective production of pyrrolidines vs pyrrolidinones via hydrosilylation of levulinic acid and levulinates by switching of the iron complex catalyst is presented herein. The reactions proceeded efficiently with various anilines and alkylamines under both visible light irradiation and thermal conditions with 43 examples in isolated yields up to 93%. Noticeably, under similar conditions, cyclic amines such as piperidines and azepanes were efficiently synthesized with yields up to 92%, by reaction of anilines with 1,5‐ or 1,6‐keto acids, respectively. Similarly, N‐arylinsolidoline compounds can be prepared from 2‐formylbenzoic acid in 57–93% yields.magnified image
High‐Performance Solution‐Processable Flexible SnSe Nanosheet Films for Lower Grade Waste Heat Recovery
Authors: Rongione Nicolas Augustus , Li Man , Wu Huan , Nguyen Huu Duy , Kang Joon Sang , Ouyang Boya , Xia Hongyan , Hu Yongjie 
Published: February 2019

AbstractLower grade waste heat recovery near room temperature is limited due to multiple technology challenges including low efficiency, high cost, and scalability. Here, a low‐cost and scalable solution process is reported to fabricate a nanostructured SnSe thin film, and a high thermoelectric performance near room temperature is demonstrated. This transport study reveals strong phonon scattering near the interfaces between SnSe nanosheets that introduces a large thermal boundary resistance and an ultralow thermal conductivity of 0.09 W m−1 K−1. Moreover, it is demonstrated that the SnSe thin film can be readily implemented on flexible plastic substrates and preserve the high thermoelectric performance over 1000 bending cycles. Together, this study demonstrates a low‐cost and scalable approach to achieve high‐performance flexible thin film energy harvesting devices to power electronics and sensors near room temperature.
Optimizing fluid viscosity for systems of multiple hydraulic fractures
Authors: Cheng Cheng , Bunger Andrew P. 
Published: February 2019

AbstractOptimal hydraulic fracturing stimulations of horizontal oil and gas wells maximize created fracture surface area and/or maximize the uniformity of stimulation. Here, we use a new, rapidly‐computing hydraulic fracture model to investigate how surface area and uniformity are impacted by interplay among multiple growing hydraulic fractures driven through permeable rocks by fluids of various viscosities. The results show the existence of a surface‐area‐optimizing viscosity that is large enough to control leak‐off but not so large that leads to unnecessarily large fracture aperture.
Sensitivity, specificity, and predictive value of oral mucosal brush biopsy for the diagnosis of peanut allergy
Authors: He Yu Ting , Reisacher William R. 
Published: February 2019

BackgroundCurrent diagnostic testing methods for peanut allergy, including serum specific immunoglobulin E (sIgE) and skin‐prick testing (SPT), have low specificity, whereas oral food challenge (OFC) carries significant risk of provoking adverse events. Mucosal brush biopsy (MBB) from the oral cavity is currently being studied as a new diagnostic test for peanut allergy, but normative data is not yet available with which to begin measuring specificity and predictive value.MethodsTwenty individuals with no history of adverse reactions from eating peanuts underwent oral MBB and serum testing for peanut sIgE. These data were then compared with previously published data from 10 individuals with a history of clinical peanut allergy, in order to generate receiver operating characteristic (ROC) curves and calculate the sensitivity, specificity, and positive and negative predictive values for both testing modalities.ResultsThe optimal cutoff levels for oral MBB and sIgE testing were 0.12 kU/L and 1.0 kU/L, respectively. At 0.12 kU/L, the sensitivity of oral MBB testing was 80% and the specificity was 85%, whereas at 1.0 kU/L, the sensitivity of sIgE testing was 50% and the specificity was 100%. From the ROC curves, the areas under the ROC curve (AUC) for oral MBB and sIgE were 0.91 (p < 0.001) and 0.74 (p = 0.007), respectively. Combination testing further increased both sensitivity and accuracy over oral MBB alone.ConclusionIn this pilot study, oral MBB demonstrated high sensitivity and specificity for screening individuals with and without oral cavity clinical reactivity to peanuts and may represent a potentially useful testing method for the diagnosis of peanut allergy in the future.
Emerging Palladium and Nickel Catalysts for Copolymerization of Olefins with Polar Monomers
Authors: Tan Chen , Chen Changle 
Published: February 2019

AbstractTransition‐metal‐catalyzed copolymerization of olefins with polar monomers represents a challenge because of the large variety of substrate‐induced side reactions. However, this approach also holds the potential for the direct synthesis of polar functionalized polyolefins with unique properties. After decades of research, only a few catalyst systems have been found to be suitable for this reaction. Some major advances in catalyst development have been made in the past five years. This Minireview summarizes some of the recent progress in the extensively studied Brookhart and Drent catalyst systems, as well as emerging alternative palladium and nickel catalysts.