bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frontal Suspension Procedure using Frontalis Muscle for Management of Ptosis
Authors: Soedjana Hardisiswo 
Published: January 2019

Background : Ptosis has a reputation as a cosmetic problem, but it is more often as a functional deficit that can have real impact on patients’ lives. Ptosis results from the dysfunction of one or both of the upper eyelid retractors and often blocks peripheral vision. Ptosis can be congenital or caused by aging. Frontal suspension is one of few techniques for correction of ptosis especially for severe ptosis.

Patient and Method : We reported one case of severe ptosis. The patient had bilateral congenital ptosis at both of upper eyelids. The upperlid excursion was 4 mm and marginal reflex distance (MRD) was 2 mm. A frontal suspension procedure using frontalis muscle was done for correction.

Result : After frontal suspension procedure, MRDare 5 mm for both eyes. There wee no difficulty for closing the eyes. The cosmetic appearance was good. Patient was satisfied with the result.
Conclusion : Frontal suspension procedure using frontalis muscle gives a good function and cosmetic result for severe ptosis.
Neural like cells and acetyl-salicylic acid alter rat brain structure and function following transient middle cerebral artery occlusion
Authors: Shamsara Ali , Sheibani Vahid , Asadi-Shekaari Majid , Nematollahi-Mahani Seyed Noureddin 
Published: January 2019

AbstractIntroductionTransient cerebral ischemia is a pandemic neurological disorder and the main aim of medical intervention is to reduce complications. Human umbilical cord mesenchymal cells (hUCMs) are capable of differentiating into neural-like cells (NLC) in vitro, therefore we investigated the neuroprotective potential of these cells in comparison to aspirin and in combination (NLC-Aspirin) on spatial memory and neural morphologic changes in male rats submitted to transient cerebral ischemia.MethodsTen days after the intervention, the improvement in learning and memory were assessed in the animals by Morris Water Maze. Thence, the animals were examined for the presence of PKH26 labeled cells in the ischemic area of the brain, the infarct volume and neural changes in the brain tissue.ResultsSignificant spatial memory deficits in the ischemic animals were detected compared with the control animals. The learning and memory were significantly improved (p ≤ 0.05) in the aspirin and NLC groups compared with the ischemic animals. Co-treatment of aspirin and NLCs did not improve the outcome. Moreover, infarction volume and neural changes were significantly altered when aspirin or NLCs were administered.ConclusionsOur data suggest the significant neuroprotective potential of aspirin and neural-like cells derived from hUCM cells in the treatment of brain ischemic stroke. Further studies are required to evaluate possible underlying mechanisms, and to evaluate the possible interactions between aspirin and stem cells in a joint treatment aimed at the recovery of cognitive impairments
Military Expenditures and Income Inequality among a Panel of OECD Countries in the Post-Cold War Era, 1990–2007
Authors: Graham Jeremy C. , Mueller Danielle 
Published: January 2019

AbstractDoes military spending exacerbate income inequality? After the Cold War, many developed countries sought to reduce military expenditures in the face of a new security environment without the clear and present threat of large-scale international conflict. The literature has presented mixed evidence on the economic effects of military spending. Moreover, during this era analysts in the OECD have become preoccupied with the economic indicator of income equality. Our study examines the relationship between military expenditures and income inequality. Complementing the established literature on the subject, we find that these two phenomena indeed possess a positive relationship and it is unlikely that this association is due to random chance. Our results are robust to the inclusion of control variables common in the literature. These findings lead us to contemplate the historical and theoretical account of the peace dividend narrative.
Variations in Verbal Encouragement Modify Isokinetic Performance
Authors: Rendos Nicole K. , Harriell Kysha , Qazi Shayaan , Regis Rebeca C. , Alipio Taislaine C. , Signorile Joseph F. 
Published: January 2019

Abstract
Rendos, NK, Harriell, K, Qazi, S, Regis, RC, Alipio, TC, and Signorile, JF. Variations in verbal encouragement modify isokinetic performance. J Strength Cond Res 33(3): 708–716, 2019—Verbal instruction and encouragement are common in exercise testing; however, the verbiage used during exercise testing is rarely controlled despite the likelihood it may affect the participant's performance. Although variations in verbal cuing based on rate and intensity have been examined during isometric contractions, they have not been examined during isokinetic testing, which is a standardized assessment of muscle performance in athletic, rehabilitation, and research settings. This study examined the effects of 4 variations in verbal encouragement during isokinetic knee flexion and extension exercises. Twenty-three healthy participants (aged 19–34 years) completed 4 isokinetic testing sessions on a Biodex isokinetic dynamometer. Each session consisted of 5, 10, and 15 repetitions at 1.05 rad·s−1 (60°·s−1), 3.14 rad·s−1 (180°·s−1), and 5.24 rad·s−1 (300°·s−1), respectively, separated by 5-minute passive recoveries. The variations in verbal encouragement randomized during each testing session used the following statements: (a) “as fast as you can” (FAST); (b) “as hard as you can” (HARD); (c) “as hard and as fast as you can” (BOTH); and (d) no verbal encouragement (NO CUE). Repeated-measures analyses of variance with a Bonferroni post hoc analysis revealed that the FAST and BOTH verbal cues produced greater work, peak torque, and power at all 3 speeds of isokinetic testing. These findings indicate the verbal cues “as fast as you can” and “as hard and as fast as you can” should be used to maximize performance during isokinetic testing.
Effects of Different Fatigue Levels on Physiological Responses and Pacing in Judo Matches
Authors: Franchini Emerson , Takito Monica Yuri , Alves Elaine Domingues , Shiroma Seihati Ary , Julio Ursula Ferreira , Humberstone Clare 
Published: January 2019

Abstract
Franchini, E, Takito, MY, Alves, ED, Shiroma, SA, Julio, UF, and Humberstone, C. Effects of different fatigue levels on physiological responses and pacing in judo matches. J Strength Cond Res 33(3): 783–792, 2019—The objective of this study was to compare athletes' pacing during judo match simulation between different fatigue states. Twelve judo athletes (30.2 ± 3.2 years old, 85.6 ± 10.8 kg, 181.0 ± 5.7 cm, 19 ± 7 years of judo experience) completed three 4-minute matches against the same opponents, at 15-minute intervals in 3 different conditions: after warm-up (Control; C); after a regular training session (totaling 90 minutes); after a high-intensity interval exercise (2 blocks of 10 sets of 20-second all-out uchi-komi, with 10-second interval between sets and 5-minute interval between blocks). All matches were mediated according to the official rules, filmed, and analyzed concerning: rating of perceived recovery (RPR), rating of perceived exertion (RPE), heart rate (before and after match), blood lactate concentrations [La] before, peak after match and delta (peak minus the prematch values), and time-motion measures (frequencies and durations of actions). Time-motion measures included athlete displacement without contact, gripping, attack, feint, groundwork combat, pauses, and high- to low-intensity effort ratio. The experimental conditions resulted in different physiological and perceived responses prematch (HR, [La], RPR) and postmatch simulations (HR and [La]peak), with no change in RPE and few changes in technical variables. There was a decrease in grip dispute time, and increase in time of displacement without contact. These technical changes were enough to preserve the pace during the matches, which seemed to be controlled by the athletes to maintain their number of attacks, feints, and RPE.
Perfectionism in Adolescents: Self-Critical Perfectionism as a Predictor of Depressive Symptoms Across the School Year
Authors: Levine Shelby L. , Green-Demers Isabelle , Werner Kaitlyn M. , Milyavskaya Marina 
Published: January 2019

Introduction: The present study examined the influence of personal standards and self-critical perfectionism on depressive and anxiety symptoms over the academic year. Methods: High-school students (N = 174) were surveyed in the late Fall and early Spring, assessing perfectionism in the Fall and mental health across the year in both the Fall and Spring. Path modelling was used to examine whether self-critical and personal standards perfectionism were related to changes in mental health across the school year. Results: Controlling for mental health at the start of the year, self-critical perfectionism predicted an increase in depressive symptoms over time, whereas personal standards perfectionism was unrelated to changes in mental health. Discussion: Results support that self-critical perfectionism is detrimental to mental health in adolescents, suggesting that future interventions should focus on reducing self-critical cognitive biases in youth.
ANALISIS DIMENSI EKONOMI KESIAPAN DAERAH DALAM PROGRAM PEMBANGUNAN PABRIK RUMPUT LAUT
Authors: Suryawati Siti Hajar , Ma’ruf Widodo Farid 
Published: January 2019

Penelitian ini bertujuan untuk menentukan status kesiapan pada dimensi ekonomi dan memberikan rekomendasi kebijakan industrialisasi rumput laut. Analisis kesiapan dilakukan dengan metode RAPFISH yang telah dimodifikasi. Hasil penelitian menunjukkan bahwa nilai indeks tingkat kesiapan pada dimensi ekonomi pembangunan pabrik rumput laut di Kabupaten Jeneponto sebesar “40,00”, Kabupaten Bone sebesar 44,33”; dan untuk Kabupaten Buton Tengah sebesar “41,65”. Nilai tersebut terletak antara 25,01 - 50,00 berarti “Kurang Siap”. Nilai indeks esiapan untuk Kabupaten Buton sebesar “71,64” yang menunjukkan kondisi “Cukup Siap” karena berada pada kisaran 50,01 – 75,00. Nilai indeks dan status kesiapan saat ini menunjukkan kondisi ekonomi wilayah erairan di Kabupaten Butin yang cukup siap dalam pembangunan pabrik rumput laut. Adapun Kabupaten Jeneponto, Bone dan Buton Tengahkurang mendukung pengembangan pabrik rumput laut, sehingga perlukan intervensi kebijakan melalui pemberian bantuan modal usaha, pelatihan teknis diversifikasi produk, dan peningkatan kapasitaskelembagaan pemasaran untuk meningkatkan status kesiapan pembangunan dimensi ekonomi.Title: Analysis of Economic Dimension Toward Local GovernmentReadiness for Developing Seaweed IndustryThis research aims to measure the readiness status on economic imension as well as to provide policy recommendation concerning seaweed industry. The readiness level had been analyzed using modified RAPFISH technique. The result suggests that the readiness level of seaweed industry inJeneponto Regency was on a score of “40,00”, Bone Regency of “44,33”, and Central Buton of “41,65”. Those value ranged between 25,02 to 50,00 indicating “Less Ready”. While readiness level of Buton Regency was on score “71,64” that indicates “Adequate” since it is on range between 50,01 to 75,00. This current index value and status indicate the readiness of economic condition in Buton territorial water to develop seaweed factory. Meanwhile, Jeneponto, Bone and Central Buton have not been ready to support the development of seaweed industry. herefore, the policy is necessary through capital, product diversification training, and enhancing capacity the marketing institution to increase the readiness level of economic development.
Der Umbruch in den modernen Gesellschaften
Authors: Stala Józef , Vodičar Janez 
Published: January 2019

This article examines the processes of transformation of European societies in XXI century, taking into consideration especially factors of post-modernity, globalisation and strong social changes. Post-modernity affects all societies, but particularly those new societies in transition. Authors take the broad concept of ‘post-modernity’ as being important for all societies that have experienced transformation in their political, social, cultural, economic, educational and religious spheres following a political shift from socialist to democratic government. The processes of social transformation affect people living in them strongly, in particular in their identity and relationships.
Aksjologiczne oblicze trzeciego wieku
Authors: Drożdż Michał 
Published: January 2019

Aksjologiczne oblicze trzeciego wieku. Celem artykułu jest pokazanie niektórych aksjologicznych aspektów starości. Myślenie aksjologiczne, czyli myślenie według wartości, przenosi nas w obszary ludzkiej odpowiedzialności za wartość życia oraz odpowiedzialności za bogactwo doświadczeń życiowych, które stanowią o życiowej mądrości ludzi starszych. Drugim polem odpowiedzialności jest troska o ludzi starszych jako świadków przeszłości, która jest nauczycielką mądrości dla przyszłości. Trzecim polem odpowiedzialności jest troska o wierność tradycji. Ludzie w podeszłym wieku są niezastąpieni w podtrzymywaniu więzi między tradycją a przyszłością. Autor artykułu pokazuje także potrzebę troski o ludzi starszych w ich wielorakich potrzebach życiowych i zagrożeniach cywilizacyjnych. Jakość życia ludzi starszych oraz ich miejsce i rola w rodzinie i społeczeństwie są nie tylko wyznacznikiem jakości życia społecznego i poziomu społecznego dobrobytu, ale przede wszystkim są wymownym znakiem jakości społecznego szacunku dla wartości i godności ludzi starszych. Autor artykułu podkreśla też ważną rolę edukacji i zdobywania wiedzy, którą oferują ludziom starszym uniwersytety trzeciego wieku.
Interpersonálne vzťahy medzi členmi rodiny
Authors: Zahatňanská Mária 
Published: January 2019

Interpersonálne vzťahy medzi členmi rodiny. Príspevok poukazuje na význam interpersonálnych vzťahov medzi členmi v rodine, ktoré ovplyvňujú nielen prístup žiaka k učeniu, jeho osobnosť, ale aj zodpovednosť, organizovanie si dňa a pod. Záleží, čo rodina pokladá za najdôležitejšie a ako to sprostredkuje ostatným členom rodiny. Vzájomné vzťahy medzi rodičmi, rodičmi a deťmi ovplyvňujú nielen psychiku dieťaťa, ale aj jeho postoje, hodnoty, ktoré prejavuje svojím správaním a konaním. Súčasťou príspevku sú aj výsledky výskumu, v ktorom sme merali sociálnu atmosféru v rodine. Sústredili sme sa na meranie a popis interpersonálnych vzťahov medzi členmi rodiny, na smery osobného rastu, ktoré sú v rodine zdôrazňované a na základnú organizačnú štruktúru rodiny.
Efficacy and Safety of Fecal Microbiota Transplantation for the treatment of Clostridium difficile Infection in Patients with Liver Cirrhosis: a single center experience
Authors: Alhaffar, BS Dana , Phelps, BS Emmalee , Fischer, MD Monika 
Published: January 2019

Background and Hypothesis: Fecal microbiota transplant (FMT) is an effective therapy approaching a 90% success rate for recurrent and severe CDI. However, patients with liver cirrhosis are generally excluded from FMT trials due to concerns of infectious complications. We aimed to investigate the efficacy and safety of FMT in these patients.
Project Methods: Electronic medical records (Cerner) and an institutional FMT database (REDCap) were utilized to gather data on patient demographics, medical history, and follow-up. Inclusion criteria were the diagnosis of liver cirrhosis and FMT to treat CDI. The primary outcomes were FMT success at 8 weeks and adverse events within 12 weeks post-FMT.
Results: Among the 267 patients in the database, 15 had liver cirrhosis. Among these, 47% (N=7) were female. The average age was 61 years (range 28-83) and they received FMT between 2014 and 2017. There were 12 (80%) patients with recurrent CDI and 3 (20%) with severe CDI. Eleven patients had decompensated cirrhosis; Child-Pough scores were A: N=4, B: N=8, and C: N=3. Five (33%) failed before 8 weeks and needed 1-3 additional FMTs for cure. Fourteen (93.3%) patients experienced adverse events. Five patients experienced unrelated SAEs (Table).
Conclusion: Patients with liver cirrhosis failed FMT more often than non-cirrhotic historical controls. While numerous AEs and SAEs were reported, few of the AEs were possibly related to the FMT and none of the SAEs were FMT-related. Importantly, no infectious complications were observed. Larger, multicenter studies are needed to establish efficacy and safety of FMT in cirrhotics before it can be recommended for widespread use.
Inhibition of IRS-1 Alters Retinal Circadian Clock
Authors: Arif Maaz , Mathew Deepa , Bhatwadekar Ashay 
Published: January 2019

Background and Hypothesis: Life on Earth has adapted to a 24-hour cycle of light and darkness. Circadian physiology coordinates temporal metabolism, hormone cycling, and sleep using clock genes. It is documented that dysregulation of clock gene expression is a key factor in the pathogenesis of diabetic retinopathy. Our goal was to explore the relationship between clock genes and the retina in diabetic milieu, and we hypothesized that disrupting downstream insulin signaling in a manner similar to diabetes in the retina would also affect the circadian clock.
Experimental Design or Project Methods: In this mouse study, we used a Per2::Luc fusion protein to perform real-time bioluminescent recording of circadian rhythms. We used SecinH3 to inhibit Insulin Receptor Signaling (IRS-1). In isolated retinas, we modulated IRS-1 to mimic the diabetic condition of impaired insulin signaling; this allowed us to directly quantify circadian rhythms in the retina. Results: Our results show that IRS-1 inhibition by SecinH3 altered the gene expression of Per2, a clock regulatory gene, over the controls. There was an increase in the period and an apparent phase shift in the presence of 100uM SecinH3.
Conclusion and Potential Impact: Our findings can help us understand the role of insulin signaling on circadian rhythms of the retina and provide another temporal dimension to view diabetic retinopathy disease progression. Ultimately, further studies and a closer understanding of the roles of molecular clocks and insulin signaling may help to develop novel therapeutics for treating some of the harmful effects of diabetes.
Defining the function of a novel TNF receptor superfamily member
Authors: Atumonye Joseph , Turner Matthew J. , Zhou Hongming , Slominski Radomir , Dawes Avery 
Published: January 2019

Background:
Insulin Growth Factor Like 1 Receptor (IGFLR1) is a putative TNF receptor superfamily member of unknown function. Transcripts for IGFLR1 are most abundant in T cells in mice and several leukocyte subsets in humans. A major limitation to understanding IGFLR1 function is the lack of biochemical data regarding IGFLR1 expression and processing in leukocytes.
Experimental Design:
A panel of human leukocyte and keratinocyte cell lines was screened for IGFLR1 transcript expression by quantitative PCR. Immunoblotting was then used to detect IGFLR1 protein and characterize which isoform(s) were expressed. Chimeric IGFLR1 construct that could be used to mimic IGFLR1 activation was also generated. This chimeric protein, hNGFR-DmrB2- hIGFLR, contains two DmrB domains that allow for multimerization in the presence of AP20187.
Results:
IGFLR1 transcript expression varied between hematopoietic cell lines with relatively low expression in MOLT4 cells (T cell line), intermediate expression in IM9 and ARH77 cells (B cell lines) and high expression in MKB cells (T cell line). Immunoblotting in these cell lines revealed a similar protein signal expression pattern. Immunoblotting also suggested that the most abundant isoform of IGFLR1 was likely isoform c, which lacks ligand-binding and transmembrane domains. With respect to the hNGFR-DmrB2-hIGFLR1 construct, the chimeric protein was detected in CHO cells by immunoblotting and biochemical analyses confirmed that addition of AP20187 induced multimerization of this protein. These findings confirm the functionality of hNGFR-DmrB2-hIGFLR1.
Potential Impact:
Biochemical studies of endogenously expressed IGFLR1 in these cell lines suggest differential mRNA splicing may play an important role in the production and function of IGFLR1 isoforms. Future studies using the hNGFR-DmrB2-hIGFLR1 construct in the aforementioned human cell lines can be performed to study IGFLR1 signaling.
A Novel Small Molecule Therapy for Corneal Neovascularization
Authors: Barry Zachary , Park Bomina , Corson Timothy W. 
Published: January 2019

Background and Hypothesis: Corneal neovascularization (CNV) is characterized by abnormal blood vessel growth in the avascular cornea. CNV can be caused by multiple insults such as trauma, infection, and immunological diseases. Current treatments have partial efficacy and associated side effects, revealing a need for novel treatments.
We identified the enzyme soluble epoxide hydrolase (sEH) as a target of an antiangiogenic small molecule we developed, SH-11037. SH-11037 was antiangiogenic in mouse models for retinal and choroidal neovascularization. However, its effect on CNV has not been explored. We hypothesize that inhibition of sEH with SH-11037 will block CNV.
Experimental Design or Project Methods: To validate sEH’s relevance in CNV, we assessed the effects of inhibition of sEH in an alkali burn CNV mouse model, treating the eyes with either eyedrops of SH-11037 or another known sEH inhibitor, t-AUCB. Neovascularization was determined by clinical assessment and immunohistochemistry. Toxicity in the retina was assessed by optical coherence tomography (OCT). Eyedrops of dexamethasone (0.1% and 0.03%) were positive controls.
Results: Clinical assessment indicated that there was a strong trend towards a decrease in CNV in the 0.1% dexamethasone control group (p = 0.0509). Further data generation is underway, but we expect to see decreased CNV in the SH-11037 and t-AUCB experimental groups, compared to the vehicle (PBS) control group.
Conclusion and Potential Impact: Upon completion of this study there is potential for a new therapeutic target for reducing CNV. This study provides the assessment of sEH’s involvement in CNV, which opens future areas of study.
Wound healing in diabetic Ossabaw pigs
Authors: Brown Cameron , Byrd James , Eggenberger Caleb , Nguyen Brian , Ameer Guillermo , Sturek Michael , Alloosh Mouhamad , Zhu Yunxiao , Duan Chongwen 
Published: January 2019

Background and Hypothesis: Wound healing drugs are effective in mouse models of diabetes, but have not been tested in diabetic swine, whose skin more closely mimics that of humans. The primary objective was to test the wound healing efficacy of lipid nanoparticles in diabetic Ossabaw miniature swine.
Experimental Design and Project Methods: Diabetes was induced in four Ossabaw miniature swine by ablation of the insulin-producing pancreatic beta cells and 5 months later the pigs received 8 surgically-induced skin wounds. EXCEDE was given at the time of surgery to prevent systemic infections for the first week of wound healing. Wounds were treated with drug-loaded nanoparticles in a hydrogel, an unmodified hydrogel, Promogran Prisma Matrix, or control phosphate-buffered saline (PBS). Photos were taken weekly to compare wound closure and complete skin thickness biopsies were taken for histological assessment.
Results: Severe diabetes was verified with plasma glucose of 357±15 mg/dL (mean±SE; n=3), while 1 pig was mildly diabetic (147±18 mg/dL). All pigs exhibited glucosuria. Normal body weight was maintained to mimic human diabetics with poor glycemic control. Complete blood counts confirmed the absence of systemic infection throughout the study. After two weeks, the percent closure by treatment was 53±4% for Prisma, 48±7% for the hydrogel, 47±5% for the lipid nanoparticles, and 59±4% for PBS.
Conclusion and Potential Impact: The data currently suggest no differences in medication efficacy, but data collection at longer durations of healing is not finished. Beneficial drug effects also may be seen on the composition (histology) of the healed skin, which has not yet been assessed.