bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women’s Environmental Cancer and Radiation Epidemiology Study
Authors: Reiner Anne S. , Sisti Julia , John Esther M. , Lynch Charles F. , Brooks Jennifer D. , Mellemkjær Lene , Boice John D. , Knight Julia A. , Concannon Patrick , Capanu Marinela , Tischkowitz Marc , Robson Mark , Liang Xiaolin , Woods Meghan , Conti David V. , Duggan David , Shore Roy , Stram Daniel O. , Thomas Duncan C. , Malone Kathleen E. , Bernstein Leslie ,   The WECARE Study Collaborative Group, Bernstein Jonine L. 
Published: April 2018

Purpose The Women’s Environmental Cancer and Radiation Epidemiology (WECARE) study demonstrated the importance of breast cancer family history on contralateral breast cancer (CBC) risk, even for noncarriers of deleterious BRCA1/2 mutations. With the completion of WECARE II, updated risk estimates are reported. Additional analyses that exclude women negative for deleterious mutations in ATM, CHEK2*1100delC, and PALB2 were performed. Patients and Methods The WECARE Study is a population-based case-control study that compared 1,521 CBC cases with 2,212 individually matched unilateral breast cancer (UBC) controls. Participants were younger than age 55 years when diagnosed with a first invasive breast cancer between 1985 and 2008. Women were interviewed about breast cancer risk factors, including family history. A subset of women was screened for deleterious mutations in BRCA1/2, ATM, CHEK2*1100delC, and PALB2. Rate ratios (RRs) were estimated using multivariable conditional logistic regression. Cumulative absolute risks (ARs) were estimated by combining RRs from the WECARE Study and population-based SEER*Stat cancer incidence data. Results Women with any first-degree relative with breast cancer had a 10-year AR of 8.1% for CBC (95% CI, 6.7% to 9.8%). Risks also were increased if the relative was diagnosed at an age younger than 40 years (10-year AR, 13.5%; 95% CI, 8.8% to 20.8%) or with CBC (10-year AR, 14.1%; 95% CI, 9.5% to 20.7%). These risks are comparable with those seen in BRCA1/2 deleterious mutation carriers (10-year AR, 18.4%; 95% CI, 16.0% to 21.3%). In the subset of women who tested negative for deleterious mutations in BRCA1/2, ATM, CHEK2*1100delC, and PALB2, estimates were unchanged. Adjustment for known breast cancer single-nucleotide polymorphisms did not affect estimates. Conclusion Breast cancer family history confers a high CBC risk, even after excluding women with deleterious mutations. Clinicians are urged to use detailed family histories to guide treatment and future screening decisions for young women with breast cancer.
Enhancer identification and activity evaluation in the red flour beetle, Tribolium castaneum
Authors: Lai Yi-Ting , Deem Kevin D. , Borràs-Castells Ferran , Sambrani Nagraj , Rudolf Heike , Suryamohan Kushal , El-Sherif Ezzat , Halfon Marc S. , McKay Daniel J. , Tomoyasu Yoshinori 
Published: April 2018

ABSTRACT
Evolution of cis-regulatory elements (such as enhancers) plays an important role in the production of diverse morphology. However, a mechanistic understanding is often limited by the absence of methods for studying enhancers in species other than established model systems. Here, we sought to establish methods to identify and test enhancer activity in the red flour beetle, Tribolium castaneum. To identify possible enhancer regions, we first obtained genome-wide chromatin profiles from various tissues and stages of Tribolium using FAIRE (formaldehyde-assisted isolation of regulatory elements)-sequencing. Comparison of these profiles revealed a distinct set of open chromatin regions in each tissue and at each stage. In addition, comparison of the FAIRE data with sets of computationally predicted (i.e. supervised cis-regulatory module-predicted) enhancers revealed a very high overlap between the two datasets. Second, using nubbin in the wing and hunchback in the embryo as case studies, we established the first universal reporter assay system that works in various contexts in Tribolium, and in a cross-species context. Together, these advances will facilitate investigation of cis-evolution and morphological diversity in Tribolium and other insects.
Entre o desencanto e a rebeldia
Authors: Paula Ana Paula Paes de 
Published: April 2018

O estilo de vida das elites gerenciais vem contribuindo para a popularização dos cursos de Administração. No decorrer do aprendizado, porém, os estudantes mostram-se desencantados com os cursos e com a carreira, o que reproduz certo vazio existencial. A obra do pensador Herbert Marcuse oferece instrumentos para compreender essa angústia e demonstra que a frustração pode revelar um movimento positivo de rebeldia e questionamento.
Violência invisível
Authors: Heloani Roberto 
Published: April 2018

Presente muitas vezes de forma imperceptível no ambiente de trabalho, o assédio moral é um tipo de violência que expõe as pessoas a situações ofensivas e humilhantes. De modo lento, porém progressivo, o assédio moral vai se traduzindo em sofrimento, dor e baixa produtividade. Os algozes corporativos costumam ser gestores autoritários, que abusam de seu poder e das situações de fragilidade de seus liderados. Identificar o fenômeno é um primeiro passo para combatê-lo.
Desenvolvendo a criatividade dos grupos de trabalho organizacionais
Authors: Thompson Leigh 
Published: April 2018

A criatividade vem se destacando cada vez mais como uma característica imprescindível para equipes e indivíduos nos atuais ambientes de trabalho das empresas. Este artigo discute as principais dificuldades e obstáculos ao desenvolvimento da criatividade nas equipes de trabalho. Ao mesmo tempo, propõe diversas estratégias para superar tais obstáculos e desenvolver as condições para que as equipes, em vez de dificultarem a criatividade individual, a estimulem.
Trabalho em Krisis
Authors: Bendassolli Pedro Fernando , Freitas Maria Ester de , Betiol Maria Irene Stocco 
Published: April 2018

Trabalho e emprego têm sido objeto de intensa discussão entre empresários, autoridades de governo e pesquisadores. Entre as diversas correntes de pensamento, uma destaca-se pela originalidade. Tal corrente,de verve crítica, advoga que o trabalho se tornou um deus pagão, e que sua centralidade na vida das pessoas deve ser questionada, revista e, talvez, abolida. Essa é a postura do grupo alemão formado em torno da revista Krisis, cujo expoente mais popular é o filósofo Robert Kurz.
Respeito em evidência
Authors: Paula Ana Paula Paes de 
Published: April 2018

É possível a existência de respeito em uma sociedade formada por indivíduos tão desiguais e diferentes? Richard Sennett propõe, neste livro, uma reflexão sobre a centralidade do respeito na formação da identidade e de um relacionamento saudável, maduro e equilibrado com o outro nos dias de hoje.
Célia Cruz [entrevistada por Andréa Leite Rodrigues]
Authors: Cruz Célia 
Published: April 2018

Célia Cruz é diretora da Ashoka Empreendedores Sociais, organização presente em 51 países que apóia indivíduos com idéias inovadoras, criatividade e determinação para provocar mudanças de grande impacto social. Economista formada pela FEA-USP e mestre em economia de empresas pela FGV-EAESP, Célia explica, nesta entrevista, o que a motivou a dedicar-se a esse tipo de atividade; trata também da evolução e das mudanças ocorridas nos últimos 10 anos no terceiro setor.
Espetáculo das raças
Authors: Jones Victoria 
Published: April 2018

A segmentação do mercado em função de características raciais ainda é uma atividade incipiente no Brasil. Ao mesmo tempo em que a metade da população do país é formada por negros e mestiços, apenas uma pequena parcela dos modelos usados em propagandas representam essa população. Este artigo, desenvolvido a partir de uma pesquisa de campo, contradiz alguns pressupostos sobre preferências dos consumidores e sugere uma revisão de certas práticas de marketing.
O futuro da estratégia [entrevistado por Flávio Carvalho de Vasconcelos e Luiz Artur Ledur Brito]
Authors: Barney Jay 
Published: April 2018

Jay Barney é considerado hoje uma das principais autoridades no estudo de estratégia. Professor de Administração na Ohio State University, é um dos criadores do conceito da “visão baseada em recursos” (RBV), pedra fundamental do campo. Durante a Terceira Conferência Internacional da Iberoamerican Academy of Management, ocorrida em São Paulo, o pesquisador concedeu esta entrevista à RAE-executivo, na qual fala sobre RBV e sua preocupação com a estratégia em contextos turbulentos.
Coaching revisitado
Authors: Guimarães Bruno Profeta 
Published: April 2018

Coletânea destaca o papel do coaching como instrumento que desenvolve competências individuais e organizacionais. O livro apresenta uma série de usos dessa ferramenta em instante no qual as empresas se tornam sistemas cada vez mais complexos e os indivíduos são chamados a se responsabilizarem por suas carreiras.
KULTIVASI MIKROALGA HIJAU PADA SUMBER NITROGEN BERBEDA UNTUK EKSTRAKSI LIPIDA
Authors: Viena Vera 
Published: April 2018

Mikroalga dikenal sebagai salah satu sumber utama penghasil bahan baku biodiesel untuk energy yang terbaharui karena kaya akan kandungan minyak. Penelitian ini mengkaji pengaruh Nitrogen dan metode ekstraksi terhadap kandungan lipida/minyak mikroalga hijau yang telah diaklimatisasi dalam limbah peternakan. Penelitian dilakukan dalam wadah kultivasi (fotobioreaktor) volume 2 L pada konsentrasi sumber Nitrogen berbeda (0 – 0,4 g/L KNO3). Selain itu juga diteliti keefektifan dua metode ekstraksi (Bligh – Dyer, dan Bligh – Dyer Modifikasi) untuk memperoleh minyak alga semaksimal mungkin. Hasil penelitian menunjukkan penambahan sumber Nitrogen yang berbeda pada kultivasi mikroalga yang telah di aklimatisasi memberikan kenaikan jumlah kandungan biomassa yang signifikan daripada yang tidak ditambahkan sumber nitrogen (kontrol). Sebaliknya kandungan lipid/minyak alga semakin menurun dengan tingginya kandungan sumber nitrogen dalam biomassa alga. Penggunaan dua metode ekstraksi berbeda tidak berpengaruh signifikan terhadap kandungan total lipida/minyak dari mikroalga. Hasil analisa GC-MS pada total lipida mikroalga menunjukkan komposisi terbesar berupa n-heksadecanoic acid (asam palmitat), octadecanoic acid (asam stearat) dan 9-(Z) octadecenoic acid (asam oleat), yang dapat berpotensi sebagai bahan baku biodiesel.
ENZIM NITRAT REDUKTASE SEBAGAI INDIKATOR KEBERHASILAN FITOREMEDIASI PADA LUMPUR SIDOARJO
Authors: Zulaika Enny 
Published: April 2018

Penelitian bertujuan untuk membuktikan keberhasilan fitoremediasi menggunakan Cassia fistula dengan indikator peningkatan aktivitas enzim nitrat reduktase di daun tanaman. Preparasi lumpur menggunakan penambahan pasir dan pupuk organik 1:1:1, 1:1:2, 1:1:3, 1:1:4. Pengukuran aktivitas nitrat reduktase menggunakan metode spektrofotometri. Substrat enzim terdiri dari buffer pospat 9,8 ml dan 0,2 ml 0,1 M NaNO3. Preparasi enzim menggunakan substrat 0,2 ml ditambah 2 ml reagen pewarna {1 ml 0,02% N-Naphtyl Ethylen Diamin (NED) dan 1 ml 0,1 % sulfanilamid dalam HCL 3 N}. Perubahan warna diukur dengan spektrofotometer UV pada panjang gelombang 540 nm. Peningkatan aktivitas enzim nitrat reduktase di daun tanaman C. fistula menunjukkan keberhasilan proses fitoremediasi terhadap lumpur Sidoarjo. Peningkatan ANR dari minggu ke 2 sampai 8 menunjukkan korelasi positip (R2 > 0,9). Modifikasi lumpur pada perlakuan V (L:P:PO = 1:1:3) merupakan ANR yang signifikan untuk indikator fitoremediasi, yaitu 0,0369 - 0,0503 µmolx10-3/mg/jam dari minggu ke 2 - 8.
PENGARUH KEGIATAN CAR FREE DAY (CFD) DI KOTA PEKANBARU UNTUK PENGURANGAN EMISI KARBON DARI KEGIATAN TRANSPORTASI
Authors: Sasmita Aryo 
Published: April 2018

Adanya penurunan kualitas udara oleh emisi karbon yang dihasilkan dari kegiatan transportasi di Pekanbaru, secara tidak langsung dapat menyebabkan perubahan iklim. Jenis gas emisi yang utama dan di sektor transportasi sebagai akibat dari pembakaran bahan bakar adalah gas CO2 dan CH4. Penelitian ini dilakukan untuk mengetahui apakah kegiatan car free day (CFD) yang dilakukan oleh pemerintah Kota Pekanbaru setiap hari minggu pada puku 06:00 hingga pukul 09:00 WIB mampu memberikan dampak mengurangi emisi karbon yang dihasilkan dari kegiatan transportasi.
Lokasi studi adalah jalan Diponegoro yang merupakan jalan yang dipergunakan untuk CFD. Pengumpulan data primer dilakukan pengaambilan perhitungan jumlah kendaraan dengan metode traffic counting. Kemudian dilakukan pengumpulan data sekunder, antara lain data perhitungan nilai emisi dengan mengumpulkan data perhitungan satuan mobil penumpang, faktor emisi untuk tiap jenis kendaraan dan data konsumsi energi spesifik untuk masing-masing kendaraan.
Dari hasil perhitungan diketahui bahwa nilai emisi karbon dioksida yang berhasil dikurangi dengan adanya kegiatan CFD adalah 236,486 kg CO2.
Determination of Specific Emission Factors of Residential for Carbon Footprint Estimation and Mapping in Banyuwangi District
Authors: Yuliana Layli 
Published: April 2018

Increasing concentration of CO2 in the atmosphere occurred due to human activities, one of which is the residential sector. In an effort to overcome the problem of increased concentrations of greenhouse gases, the Government of Indonesia launched the first step action plan to mitigate climate change by doing GHG inventory in accordance with the IPCC guidelines. To increase the accuracy in conducting an inventory, each country was encouraged to draw up specific emission factors. This study aims to determine the residential sector of specific emission factors and analyze the distribution of emissions by mapping the carbon footprint. Calculation method was using the IPCC. Activity data was fuel for cooking in urban and rural areas. The results of the questionnaire showed a different pattern of household fuel consumption in urban and rural areas, households in urban areas generally use LPG, whereas in the rural areas wear LPG and firewood. From the results obtained by analysis, the value of specific emission factor of fuel use for cooking in urban areas 0,3855 tons of CO2/ household.year, in rural areas 1,7776 tons of CO2/household.year. The result of calculation and mapping shows higher carbon footprint of fuel in rural areas due to the use of firewood.
MENUJU PELABUHAN BERKELANJUTAN TANPA INVESTASI
Authors: Haris Muhammad 
Published: April 2018

Persaingan antar pelabuhan khususnya di terminal peti kemas, mendesak pihak Terminal Peti Kemas Belawan (BICT) untuk meningkatkan kinerja operasional pelabuhan. Meningkatnya isu lingkungan seperti perubahan iklim dan konsumsi energi menjadikan pengelola pelabuhan harus merancang pengembangan pelabuhan berwawasan lingkungan yang berkelanjutan. Operasional terminal peti kemas mencakup tiga jenis peralatan bongkar muat, yaitu container crane (CC), Rubber Tyred Gantry Crane (RTGC) dan truk. Tingginya biaya investasi peralatan bongkar muat membuat pengelola pelabuhan menerapkan optimalisasi operasional menuju pelabuhan berwawasan lingkungan. Penelitian ini bertujuan untuk merekonstruksi kembali operasional dengan menggunakan metode penjadualan peralatan dan modified distributionpada penataan peti kemas. Hasil optimalisasi penelitian ini dapat mengurangi 44% effective time, konsumsi energi, efisiensi tenaga kerja dan efisiensi biaya logistik dengan peningkatan produktivitas menjadi 25B/C/H. Penelitian ini berkontribusi pada tataran teknis pengembangan pelabuhan berkelanjutan tanpa melakukan investasi.
Exploring Prospective Teachers’ Reflections in the Context of Conducting Clinical Interviews
Authors: Taylan Rukiye Didem 
Published: April 2018

<p style="text-align:justify">This study investigated prospective mathematics teachers’ reflections on the experience of designing and conducting one-to-one clinical interviews with middle school students in the context of an elective course on use of video in teacher learning. Prospective teachers were asked to write about weaknesses and strengths in student understanding as well as their own performance as an interviewer in terms of asking questions and responding to student thinking in their reflections on conducting clinical interviews. Furthermore, prospective teachers were also asked to reflect on what they would do differently in order to conduct better clinical interviews. Nature of prospective teachers’ reflections were analyzed by using existing frameworks (through constructs of reflection-on-action and reflection-for-action) and by using thematic analysis. Results of data analyses revealed that prospective teachers had more difficulties in providing meaningful reflection-for-action which was related to alternative decisions and planning for future similar interviews. Thematic analysis results revealed prospective teachers’ learning were grouped under three categories: conducting clinical interviews as part of being a teacher, complexity of conducting clinical interviews, and personal theories about middle school students. There are implications for both teacher learning and research.</p>
The Effect of 7E Learning Model on Conceptual Understandings of Prospective Science Teachers on 'de Broglie Matter Waves' Subject
Authors: Gorecek-Baybars Meryem , Kucukozer Huseyin 
Published: April 2018

<p style="text-align:justify">The object of this study is to determine the conceptual understanding that prospective Science teachers have relating "de Broglie: Matter waves" and to investigate the effect of the instruction performed, on the conceptual understanding. This study was performed at a state university located in the western part of Turkey, with the Faculty of Education-Science Teaching students (2nd year / 48 individual) in the academic year of 2010-2011. The study was planned as a single group pretest-posttest design. A two-step question was used in the study, prior to and after the instruction. Lessons were conducted using the 7E learning model in the instruction process. When all these results are evaluated, it can be said that the conceptual understanding of the prospective teachers regarding "de Broglie; matter waves" has been taken place. In general, when all the sections are examined, it has been observed that the prospective teachers have more alternative concepts prior to the instruction and more scientific concepts after the instruction. In this process, besides instruction, the prospective teachers have not taken any place in a different application regarding the basic concepts of quantum physics. Therefore, it has been determined that the 7E learning model used in the research and the activities included in the 7E learning model are effective in conceptual understanding.</p>
Diagnosing slipped capital femoral epiphysis amongst various medical specialists
Authors: Lam A. , Boenerjous S. A. , Lo Y. , Abzug J. M. , Kurian J. , Liszewski M. C. , Sanderson D. E. , Scholnick J. M. , Taragin B H. , Gomez J. A. , Otsuka N. Y. , Hanstein R. 
Published: April 2018

Purpose To evaluate sensitivity, specificity and accuracy of a radiographic slipped capital femoral epiphysis (SCFE)-diagnosis among medical specialists. Methods Three paediatricians, three paediatric radiologists and three paediatric orthopaedic surgeons completed two rounds of a survey of anteroposterior and frog-leg lateral radiographs of patients with a diagnosis of SCFE (25), femoroacetabular impingement (four), Legg-Calvé-Perthes (11) or no hip pathology (ten). Intra- and interobserver agreement among specialties regarding the diagnosis of a SCFE were assessed using Cohen's kappa coefficient (κ). Diagnostic accuracy of SCFE relative to the benchmark, a combination of the radiographic diagnosis based on Klein's line, clinical symptoms and surgical treatment, was assessed computing sensitivity, specificity and accuracy. Results Intraobserver agreement between the surveys was moderate among paediatricians (κ-range, 0.44 to 0.52), moderate to almost perfect among orthopaedic surgeons (κ-range, 0.79 to 0.88) and almost perfect among paediatric radiologists (κ-range, 0.83 to 1.00). Interobserver agreement for survey 1 and 2 was slight among paediatricians (mean κ, 0.19), substantial among orthopaedic surgeons (mean κ, 0.77) and almost perfect among paediatric radiologists (mean κ, 0.86). Sensitivity of SCFE-diagnosis was high among radiologists and orthopaedic surgeons (88% to 100% for both specialties), but lower for paediatricians (24% to 76%). Specificity was high among radiologists and orthopaedic surgeons (72% to 84%), however, variable among paediatricians (56% to 80%). Accuracy of a SCFE-diagnosis was highest in radiologists (84% to 92%), followed by orthopaedic surgeons (80% to 88%) and paediatricians (48% to 78%). Conclusion SCFE can be detected on radiographs by different medical specialties. Intra- and interobserver agreement, specificity, sensitivity and accuracy for radiographic SCFE-diagnosis amongst paediatric radiologists and orthopaedic surgeons are better than that of general paediatricians. Level of Evidence II
Feminization of labour, defeminization of time banks: Digital time banking and unpaid virtual work
Authors: del Moral-Espín Lucía , Pais Ivana 
Published: April 2018

Abstract
This article addresses the notion of post-Fordism and the feminization of labour in order to provide deeper insight into the shifting boundaries of work in the Digital Age and how new forms of virtual work emerge. Specifically, this paper approaches digital time banking as a specific form of unpaid virtual work. We analyse six case studies to reveal the different gendered natures of digital and non-digital time banks (TBs) and to suggest that the defeminization (understood fundamentally, but not only, as the lack of presence and involvement of women and affective labour) of digital time banking may be connected with the so-called third gender digital divide. This leads us to discuss the underrepresentation of women in other digitally mediated and sharing economy initiatives, to suggest some possible explanations, and warn against the post-feminization of culture.
Pregnancy with uncorrected tetralogy of Fallot (TOF), pulmonary atresia and major aorto-pulmonary collateral arteries (MAPCA)
Authors: Gomez Luis M. , Jones Ryan C. , Fuertes Maria R. , Tate Danielle L. , Ramanathan Jaya 
Published: April 2018

Abstract
Pregnancy with uncorrected tetralogy of Fallot (TOF) is a rare event, and increases the risk for fetal growth restriction and adverse outcomes related to worsening right-to-left shunt, cyanosis, pulmonary hypertension and arrhythmia. Obstetric management is made on a case-by-case basis. Patients who remain stable can achieve term pregnancies and the mode of delivery can be based on obstetric indications. We present the case of a 21-year-old primigravida with baseline cyanosis, oxygen saturation 90% at rest (74% with activities), hematocrit 50%, and echocardiogram showing pulmonary atresia, ventricular septal defect (VSD), and major aorto-pulmonary collateral arteries (MAPCA). We managed her with aspirin, metoprolol and oxygen supplementation. She delivered at 38 weeks (fetal growth restriction) via cesarean; she received epidural and endocarditis prophylaxis. Three years later, she presented pregnant and had a repeat cesarean at term. Both newborns had normal structural hearts. Knowledge of the cardiovascular physiology during pregnancy and baseline assessment, and a multidisciplinary management are key aspects in the management of these cases during pregnancy.