bluuebunny/crossref_metadata_2025_split huggingface dataset:
10268- MET-24 A CASE OF BRAIN METASTASIS OF UTERINE CANCER REFRACTORY TO TREATMENT DUE TO RAPID CLINICAL PROGRESSION.
Authors: Ueno Takahiro , Ro Buntou , Tsuzuki Shunsuke , Koriyama Shunichi , Kawamata Takakazu , Muragaki Yoshihiro 
Published: November 2024

Abstract
The patient was a 57-year-old woman. She underwent laparotomy 14 months before her ER visit because of enlarged pelvic lymph nodes during follow-up for uterine adenomyosis. The pathological diagnosis was adenocarcinoma of adenomyosis origin, with metastasis to pelvic lymph nodes and a diagnosis of FIGO classification stage 3C1. She had been treated with six courses of TC (Paclitaxel+Carboplatin) postoperatively and was judged CR 2 months before the visit. She had visited the ER due to nausea and dizziness, and a head scan revealed a cerebellar tumor. She was admitted to the hospital on the same day for close examination and treatment. After admission, an MRI revealed a single, uniformly contrasted lesion, which was suspected of metastatic brain tumor from uterine cancer. On the 10th day of admission, we performed tumor resection and ventricular drainage. On the 15th day, nausea and dizziness improved, and the patient could eat full meals. On the 18th day, back pain and gastric discomfort due to postoperative defecation disorder appeared. FDG-PET performed on the 22nd day revealed systemic metastases, including thoracic spine and retroperitoneum. On the 33rd day, the patient developed impaired consciousness, and spinal fluid analysis showed positive atypical cells and hydrocephalus on a CT scan. After the surgery, her consciousness disorder improved, but she complicated thoracoabdominal effusion, urinary retention, and hydronephrosis, and died of multiple organ failure on the 47th day of hospitalization. Brain metastases from uterine cancer are rare, and there is little information on their clinical features, management, and prognosis. At the time of diagnosis, the patient was in an advanced state of organ failure due to metastatic lesions. When we detect brain metastasis in patients with uterine cancer, we should note that a high rate of metastasis to other organs would exist. Then, early systemic examination and therapeutic intervention are necessary.
10237- MNG-8 AUTOMATED VOLUMETRY OF MENINGIOMAS IN CONTRAST-ENHANCED T1-WEIGHTED MRI USING DEEP LEARNING
Authors: Hirayama Ryuichi , Iwata Takamitsu , Yamada Shuhei , Nakamura Natsuki , Wada Yuki , Nishimoto Keisuke , Nakagawa Kanji , Kawamoto Yuki , Murakami Koki , Utshugi Reina , Yokota Chisato , Kijima Noriyuki , Kishima Haruhiko 
Published: November 2024

Abstract

BACKGROUND
With the widespread use of MRI equipment and brain docks, there are more opportunities to perform follow-up observation for meningiomas. In recent years, attempts have been made to predict prognosis by using tumor volume as an imaging biomarker. On the other hand, manual lesion extraction by a reader with anatomical knowledge is indispensable for volume measurement, which requires a certain amount of labor and time. We developed a simple and highly reproducible application for automated volume measurement of meningiomas using artificial intelligence and report its accuracy for use as an imaging biomarker of tumor volume in real clinical practice.

METHODS
178 patients with meningiomas who underwent MRI at Osaka University Hospital were included in the study. Contrast-enhanced T1-weighted images were used for manual lesion extraction by two neurosurgeons. These annotated image data were randomly divided into training (90%) and testing (10%). The deeplabV3 model was used to train the artificial intelligence, and leave-one-out cross-validation was used to train and validate the automated model. The test data were used for comparison, and the agreement rate (Dice index) on the images of the automatically extracted regions and the error rate of the calculated tumor volume (mean square error rate: RMSPE) were used as indices of measurement performance. Results: The agreement rate between the images of the automatically extracted area and the test data was 92.3± 5.1% on average. The error rate for volume was 9.5±1.2%. Conclusion: This application using artificial intelligence was considered to have a certain validity in terms of accuracy of automatic lesion extraction.
10009- COT-3 IMPACT OF LIVING CIRCUMSTANCES OF THE OLD GLIOMA PATIENTS ON EARLY INTERVENTION
Authors: Fujita Shohei , Kawanishi Yu , Fukuda Hitoshi , Nakajo Takahito , Ueba Tetsuya 
Published: November 2024

Abstract

AIM
Glioma is a growing malignant brain tumor, so early diagnosis and early treatment are important. The declining KPS due to symptom progression is associated with the declining postoperative KPS and tumor resection rate, shortened patient survival. The associating between social connections and medical treatment in elderly glioma patients is unclear. To determine whether social connections around the senior patient associate the decreasing postoperative KPS.

METHODS
We have studied 121 patients with glioma operative at the Kochi University Hospital from 2013 to 2022. Preoperative KPS decline outcome was defined as KPS&lt;80. Patients’ social connections with their surroundings were classified into three groups based on record information: “living alone,” “senior couple,” and “with children’s involvement. “First, the patients were classified into a younger group under 60 years old (40 patients) and an elderly group over 60 years old (81 patients), and the preoperative KPS was compared between the two groups. Second, we examined whether social connections associated declining preoperative KPS in the elderly subgroup.

RESULTS
In the elderly group, the proportion of patients with declining preoperative KPS was 29/81, which was significantly higher than the proportion in the younger group (6/40) (P=0.031, chi-square test). In the elderly group, the rate of declining preoperative KPS according to social connections was lower in those with “ with children’s involvement “ (2/14) compared to those who “lived alone” (8/19) and those who “ senior couple “ (19/48), indicating that child involvement was associated with higher preoperative KPS in elderly patients with glioma.

CONCLUSION
Glioma patients over 60 years of age are at risk of declining preoperative KPS, especially in the setting of low children’s involvement. As the population continues to age, it will be necessary to consider the social connections between glioma patients and those around them and encourage early hospital visit.
IL-1 IDHWT GLIOBLASTOMA LONGITUDINAL MOLECULAR EVOLUTION
Authors: Lucas C G , Al-Adli N , Young J S , Gupta R , Morshed R A , Wu J , Ravindranthan A , Shai A , Oberheim Bush N A , Taylor J W , de Groot J , Villanueva-Meyer J E , Pekmezci M , Perry A , Bolen A W , Theodosopoulos P V , Aghi M K , Chang E F , Hervey-Jumper S L , Raleigh D R , Molinaro A M , Costello J , Diaz A A , Clarke J L , Butowski N A , Phillips J J , Chang S M , Berger M S , Solomon D A 
Published: November 2024

Abstract
We performed comprehensive histopathologic, genomic, and epigenomic evaluation of paired initial and recurrent glioblastoma specimens from 106 patients to investigate the molecular evolution and cellular phenotypes underlying differential treatment responses. While TERT promoter mutation and CDKN2A homozygous deletion were early events during gliomagenesis shared by initial and recurrent tumors, most other recurrent genetic alterations (e.g., EGFR, PTEN, NF1) were commonly private to initial or recurrent tumors indicating acquisition later during clonal evolution. Further, glioblastomas exhibited heterogeneous epigenomic evolution with subsets becoming more globally hypermethylated, hypomethylated, or remaining stable. Glioblastoma that underwent sarcomatous transformation at recurrence had inferior survival and were significantly enriched in NF1, TP53, and RB1 alterations and the Mesenchymal epigenetic class. Patients who developed somatic hypermutation following temozolomide treatment had significantly longer interval to disease recurrence and prolonged overall survival, and hypermethylation at four specific CpG sites in the promoter region of MGMT was significantly associated with this development of hypermutation. Finally, an epigenomic evolution signature incorporating change in DNA methylation levels across 347 critical CpG sites was developed that significantly correlated with clinical outcomes. This talk will describe how GBM undergoes heterogeneous genetic, epigenetic, and cellular evolution that underlies prognostically different treatment responses.
IL-5 EPIGENETIC REGULATION IN GLIOMA METABOLISM
Authors: Hashizume Rintaro 
Published: November 2024

Abstract
In most cancer cells including glioma cells, glucose is at-least partially metabolized to lactate through the Warburg Effect, which refers to the non-oxidative metabolism of glucose even in the presence of sufficient oxygen. In addition to the advantage conferred upon glioma cells by the canonical glycolysis pathway, through supporting rapid proliferation and survival, its end product, lactate, serves as a key factor to regulate H3K27 acetylation (H3K27ac) through histone deacetylases (HDACs). We and others have shown that increase lactate metabolism related to tumor progression in high-grade gliomas including diffuse midline glioma (DMGs). In the orthotopic DMG patient-derived xenograft models, the levels of lactate were elevated relative to the contralateral normal brain using hyperpolarized carbon-13 (13C) magnetic resonance spectroscopic imaging (MRSI), indicating increase lactate metabolism associated DMG growth. Deregulated glucose metabolism can be therapeutically targeted at different levels, from the master regulators that control glucose metabolism to key enzymes controlling rate-limiting steps in glycolytic pathways. Recent integrate analysis using RNA- and ChIP- sequencing uncovered a novel function of lactate in transcriptional regulation and chromatin machinery, offering a promising avenue for therapeutic exploration. Inhibition of lactate dehydrogenase (LDH), the enzyme involved in lactate production, induced loss of histone H3K27ac and regulated the expression of key morphogenesis genes. The epigenetic dysregulation in DMG harboring histone gene mutation, H3K27M, caused a global reduction of H3K27 methylation. While decreasing K27 methylation, the K27M mutation also causes an increase in H3K27ac, in turn, leads to extensive transcriptional reprogramming of mutant cells. These findings provide the rational for development of novel therapeutic strategies to target lactate-dependent epigenetic regulation in DMG. This new therapeutic approach may benefit not only the patients that are afflicted with highly aggressive brain cancers but also perhaps those afflicted with other cancer subtypes.
A systematic review of the ethnopharmacology and phytochemistry of Callistemon citrinus “Myrtaceae”: Implication for phytomedicine future prospect
Authors: Hope Onohuean , Naster Cherop , Sarah Nwozo O , Sarah Najophe E , Sarad Pawar Naik Bukke 
Published: November 2024

Abstract

Background
The increase in bacterial infection, combined with antibacterial resistance, remains a global threat, fueling the popularity of medicinal herbs as people seek alternatives to synthetic medicine. This review synthesizes scientific evidence regarding the medicinal uses of lemon bottle-brush (Callistemon citrinus (Curtis) (C. citrinus) to inspire future research prospects.

Methods
Scientific evidence was thoroughly synthesized from databases (PubMed, Web of science (WOS), and Scopus).

Results
One hundred articles reported the medicinal use of C. citrinus, while 39 (39%) provided evidence of its ethnopharmacology and phytochemistry. The C. citrinus medicinal plant research progresses at an annual growth rate of 6.41%. Most prolific authors were from India and Iran countries. The leaf extracts and essential oil are the most studied part of the plant for microbial sensitivity, respiratory disorders, haemorrhoids, and anti-inflammatory among several illness. Phytochemistry and phytomedicinal analysis of C. citrinus revealed several bioactive compounds, including 1, 8-cineole, α-pinene and β-pinene, and GC-MS and HPLC as the most used method of identification/characterization. Most of the included studies omitted information about the standardization preparation methods or formulation composition. Poor ethnobotanical studies, toxicological profile and efficacy studies of C. citrinus have hindered the possible translational progress. Also, despite its pharmacological implications, no study of human subjects and clinical trials has been done on the plants.

Conclusion
This systematic review shows the research progress and provides evidence of details of phytochemical constituents and ethnopharmacology benefits of C citrinus. It highlights research gaps and future engagement in advancing the medicinal use of C citrinus.
Evaluation of the efficacy and safety of acupuncture assisted treatment for atrial fibrillation: A systematic review and meta-analysis based on randomized controlled trials
Authors: Liu Yuqing , Pang Xuemeng , Wang Yajuan , Liu Xu , Jiang Hongju 
Published: November 2024

Background:
To systematically evaluate the efficacy and safety of acupuncture in the treatment of atrial fibrillation (AF).

Methods:
Eight databases were searched. The search time limit is from January 2000 to November 2023. All randomized controlled trials on acupuncture treatment of AF were included. After the literature screening, data extraction and quality evaluation were carried out independently according to the inclusion and exclusion criteria, and the included literature was analyzed by Meta using RevMan 5.4 software.

Results:
A total of 15 research studies on randomized controlled trials were included, involving 1960 patients. The results of the meta-analysis showed that acupuncture therapy could increase the sinus cardioversion rate of patients with AF, and the difference was statistically significant (relative risk = 1.21, 25% confidence interval (CI) [1.11, 1.31], P < .001). The clinically effective rate of the acupuncture plus drug treatment group was higher than that of the drug treatment group (relative risk = 1.32, 95% CI [1.19, 1.46], P < .01). Acupuncture plus other conventional therapies treatment was more helpful in reducing the ventricular rate of patients with AF (mean difference = -7.89, 95% CI [-14.52, -1.26], P = .006). The cardioversion time of patients with AF treated with acupuncture plus conventional therapies was shorter than those treated with traditional therapies alone (standardized mean difference = -1.82, 95% CI [-3.28, -0.35], P = .01). No severe adverse reactions such as hemorrhage, hematoma, or local infection caused by acupuncture were reported in the study.

Conclusion:
The available evidence shows that acupuncture can effectively improve the total clinical effective rate and sinus rhythm recovery rate, shorten the recovery time of sinus rhythm, and reduce the ventricular rate, and there are no apparent adverse reactions. However, a limited number of studies may affect the generalizability of the findings. Future studies should include more extensive and diverse studies to enhance the power and generalizability of the findings.
Endoscopic nasal multilevel skull base reconstruction combined with lumbar cistern drainage in the treatment of infection caused by cerebrospinal fluid leakage: A case report
Authors: Zhou Longshan , Yang Xiaoqian , Lv Jiatao , Chong Zonglei 
Published: November 2024

Rationale:
Traumatic cerebrospinal fluid leakage can cause complications such as meningitis, ventriculitis and brain abscess. It is necessary to formulate individualized treatment strategies, such as the use of antibiotics and skull base reconstruction methods. The application of nasal septum mucosal flap can significantly reduce the incidence of cerebrospinal fluid leakage. Neuroendoscope has been widely used in the treatment of skull base diseases, and the application of continuous lumbar cistern drainage technology has effectively controlled cerebrospinal fluid leakage. This paper introduces a case of long-term cerebrospinal fluid leakage complicated with infection. Neuroendoscopic multilevel skull base reconstruction combined with lumbar cistern drainage has achieved good clinical results, and this combined treatment is rarely reported in the literature. In order to promote the surgical effect of cerebrospinal fluid leakage, this combined treatment scheme is introduced here.

Patient concerns:
A 43-year-old male was admitted with headache for 7 days, aggravation with fever and vomiting for 2 days.

Diagnoses:
Cerebrospinal fluid culture suggests central nervous system infection, history and symptoms suggest traumatic cerebrospinal fluid rhinorrhea, and computed tomography (CT) shows old skull base fracture.

Interventions:
Intracranial infection was controlled after anti-infection treatment with sensitive antibacterial drug ceftriaxone sodium. Repair of cerebrospinal fluid rhinorrhea by transsphenoidal endoscope. Continuous lumbar cistern drainage (LCD) was performed after operation to promote the healing of the leak.

Outcomes:
After comprehensive treatment, the patient did not have CSF rhinorrhea again and was discharged.

Lessons:
Antibiotics combined with endoscopic multi-segment skull base reconstruction and lumbar cistern drainage are effective in treating infection caused by cerebrospinal fluid leakage.
Simultaneous bilateral midshaft clavicle fractures (Allman Type I): Case series
Authors: Cen Chaode , Xie Yuehua , Liu Mao , Wu Yan , Cao Aixin , He Daqing 
Published: November 2024

Rationale:
A simultaneous bilateral fracture of the middle clavicle is a very rare injury in clinical practice, and the necessity of surgical intervention and treatment modality remains a topic of debate.

Patient concerns:
We report a case of multiple injuries in a 40-year-old woman following a road traffic accident and another case of polytrauma in a 46-year-old man following a collision injury.

Diagnoses:
The radiographs of the bilateral shoulder joints and the 3-dimensional reconstruction CT of the chest showed the fractures in the middle third of the clavicle on both sides. In addition, concurrent injuries were not overlooked.

Interventions:
Until the patient’s life-threatening injury is prioritized and the patient’s vital signs are stable, patients were treated with the anatomical locking plate to stabilize the bilateral clavicle fractures. Progressive functional exercises were implemented following the operation.

Outcomes:
At the 2-month follow-up examination, the patients showed excellent range of motion and functional outcomes.

Lessons:
Given the rarity of this combined injury, it is crucial to minimize the duration of functional impairment and encourage early functional exercises for both shoulder joints. We recommend that surgical indications be judiciously relaxed to allow for open reduction and internal fixation using locking plates.
Efficacy and safety of early administration of remdesivir in hemodialysis patients with COVID-19: A case report and literature review
Authors: Oshiro Nanako , Kinjo Takeshi , Aharen Daigo , Kudo Yuki , Katsuren Eisuke , Omine Kumiko , Nakamura Takuto , Zamami Ryo , Ishida Akio , Miyagi Kazuya , Nakamatsu Masashi , Yamamoto Kazuko , Kusunose Kenya , Fujita Jiro , Ohya Yusuke , Kohagura Kentaro 
Published: November 2024

Rationale:
Although the mortality of severe coronavirus disease 2019 (COVID-19) has decreased after the emergence of the Omicron variant, it remains high in patients on hemodialysis (HD). Remdesivir (RDV) is considered as the first line drug for hospitalized COVID-19 patients, however the evidence regarding the usage in HD patients is lacking because clinical trials of RDV have excluded HD patients for safety reasons. Thus, accumulation of knowledge on the regimen, efficacy, and tolerability of RDV in HD patients is important.

Patient concerns:
A nosocomial COVID-19 cluster was occurred from August 31 to October 12 in 2021 when the Delta variant was predominant. During the cluster, 11 health-care workers and 20 inpatients including 7 HD patients were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Diagnoses:
The diagnosis of COVID-19 was confirmed by the real-time polymerase chain reaction (PCR) for SARS-CoV-2.

Interventions:
RDV was initiated within 16 hours after the onset of fever (≥ 37.4°C) or positive PCR result in all HD patients, and continued at 100 mg/day intravenously once daily for either consecutive 5 or 10 days.

Outcomes:
All patients fully recovered within 2 weeks and did not develop severe COVID-19. Two patients experienced mild liver dysfunction, but it was temporary and remitted spontaneously even continuing RDV treatment. Discontinuation of RDV therapy due to adverse events was not required in any patients.

Lessons:
Present cases indicated early intervention with RDV may contribute the favorable outcome and daily administration of RDV for up to 10 days was well tolerated even in HD patients. Literature review showed no previous article reported the efficacy and safety of such earlier and longer administration of remdesivir as in the present cases, therefore this report is informative for clinicians to consider the usage of RDV in HD patients.
Exercise strategies for reversing cardiopulmonary deconditioning in obese children with bronchial asthma: A randomized comparative effectiveness study of constant-load and graded aerobic training
Authors: Elnaggar Ragab K. , Osailan Ahmad M. , Alghadier Mshari , Elnegamy Tamer E. , Morsy Walaa E. , Abdrabo Mohamed S. , Qissi Fahad A. , Shendy Mohammed A. , Mohamed Rania R. , Elfakharany Mahmoud S. 
Published: November 2024

Background:
This study evaluates the differential effects of constant-load (CL-AE) and graded (G-AE) aerobic exercise training approaches on cardiopulmonary fitness and functional capacity in obese children with bronchial asthma (BA).

Methods:
Seventy-eight obese children with moderate BA (age: 14.14 ± 2.31 years; body mass index: 31.93 ± 1.26 kg/m2) were randomly assigned to 3 intervention-based groups: control, CL-AE, or G-AE group (n = 26 in a group). The cardiorespiratory fitness (peak oxygen uptake, minute ventilation [VE], ventilation-oxygen uptake ratio, stroke volume of oxygen, oxygen/carbon-dioxide exchange ratio, heart rate maximum, and heart rate recovery at one minute) and functional capacity (6-minute walk test and perceived dyspnea and fatigue) were assessed at the baseline and posttreatment.

Results:
The G-AE group exhibited more favorable changes in cardiorespiratory fitness [VO2peak (P = .03), VE (P = .021), VE/VO2 (P = .032), SVO2 (P = .025), O2/CO2 ratio (P = .004), HRmax (P = .016), HRR1 (P = .046)] and functional capacity [6-minute walk test (P = .021), dyspnea (P = .041), fatigue (P = .04)] as compared to the CL-AE group.

Conclusion:
The G-AE, compared to CL-AE, appears to be a more potent stimulus for enhancing cardiorespiratory fitness and functional capacity in obese children with BA. Further investigations are, however, required to corroborate the observed effects.