bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pterygoid process fracture during dental extraction – an unusual complication
Authors: Souza Gustavo Almeida , Santos Zarina Tatia , Sverzut Alexander Tadeu , Asprino Luciana , De Moraes Márcio 
Published: March 2018

INTRODUCTION: The extraction of the upper third molar is a simple and common procedure in Oral and Maxillofacial Surgery daily practice. Infection, facial swelling, trismus, wound dehiscence, root fracture, oroantral fistula, iatrogenic displacement, fracture of the maxillary tuberosity are some of the complications that can occur during third molar extraction.CASE DESCRIPTION: In this article, an unusual fracture of the pterygoid process during upper third molar extraction and a minimally invasive technique for treatment are described.CONCLUSION: It is important to recognize the fracture and not remove the fragment before a complementary image exam, it will guide the type of treatment that should be use.
Fatores de experiência linguística associados à proficiência autoavaliada por usuários de inglês como língua adicional
Authors: Scholl Ana Paula , Finger Ingrid , Fontes Ana Beatriz Arêas da Luz 
Published: March 2018

Pesquisadores sugerem que o aprendizado de línguas adicionais e a experiência com o uso dessas línguas tem um papel importante no desenvolvimento da competência linguística de um indivíduo (MARIAN, BLUMENFELD e KAUSHANSKAYA, 2007). O objetivo do presente estudo foi investigar quais fatores relacionados a uma experiência linguística são associados à proficiência autoavaliada pelos usuários de uma língua adicional. Para esse fim, correlacionamos variáveis da experiência linguística de 535 participantes brasileiros falantes de inglês como língua adicional com a proficiência reportada por eles no Questionário de Experiência e Proficiência Linguística (QuExPLi). Os resultados sugerem que os fatores relacionados a marcos de idade, tempo de imersão e uso atual da língua associam-se de forma significativa à proficiência autorreportada pelosparticipantes.
Aspectos hipermodernos no conto “O importado vermelho de Noé”, de André Sant’anna
Authors: Moura da Silva Paulo Ricardo 
Published: March 2018

O presente artigo tem como objetivo primordial discutir criticamente o conto “O importado vermelho de Noé”, do escritor André Sant’Anna (2007), presente no livro Sexo e amizade, sob a perspectiva das reflexões de Gilles Lipovetsky (2004) sobre os aspectos fundamentais que constituem a hipermodernidade. Atentamo-nos em nossa leitura crítica para os diálogos possíveis entre o conto de André Sant’Anna e as discussões de Gilles Lipovetsky de modo a aproximá-los para verificar certos aspectos convergentes entre estes dois discursos, como, por exemplo, o consumo, a velocidade, bem como as ressignificações nas relações que os indivíduos hipermodernos estabelecem com o tempo.
Processos cognitivos de domínio geral: evidências em instanciações da construção transitiva
Authors: De Lucena Nedja Lima 
Published: March 2018

Este artigo examina processos cognitivos de domínio geral que estão atrelados ao uso linguístico, mais precisamente à manifestação discursiva de um tipo de construção de estrutura argumental: a construção transitiva. Seu objetivo é discutir evidências da atuação desses processos nas instanciações dessa construção a partir do exame de dados empíricos oriundos de situações comunicativas reais. O trabalho ancora-se nos pressupostos teóricos da Linguística Funcional Centrada no Uso, que abriga a concepção de que as línguas são moldadas pela complexa interação de princípios cognitivos e funcionais. Esses desempenham um papel basilar na manifestação dos fenômenos linguísticos. Alinhado a esse viés teórico, este artigo adota a perspectiva da gramática de construção na análise. Evidencia-se que os processos cognitivos de domínio geral atrelados à experiência motivam a expressão de instanciações da construção transitiva que se afastam do membro prototípico, mas que, por analogia, são tomadas do modo semelhante. Os padrões linguísticos são vistos como consequência da atuação desses processos cognitivos e, ao observá-los, estamos situando a língua num amplo contexto do comportamento humano.
A influência da reflexividade verbal no processamento anáfora se
Authors: Henrique Judithe Genuíno , Oliveira Rosana Costa de , Gonçalves Calaça de Souza Flávia 
Published: March 2018

A pesquisa elaborada neste estudo investiga a reflexividade verbal e seu papel no processamento da anáfora se. No intuito de verificar quais verbos são considerados mais aceitáveis na leitura de sentenças contendo a anáfora se, realizamos um teste offline de julgamento de aceitabilidade com falantes nativos do português brasileiro. Utilizamo-nos da noção de reflexividade proposta por Reinhart e Reuland (1993), os quais predizem que a reflexividade é uma propriedade dos predicados, bem como dos trabalhos de Christiano (1991) e Mello (2008), pois estes estabeleceram uma classificação mais categórica para os verbos com características mais reflexivas, dividindo-os em três níveis: primário – penteou, secundário – sentou, e terciário – acusou, de acordo com o grau de reflexividade. De modo geral, os resultados encontrados evidenciaram que a propriedade da reflexividade pode estar presente tanto na anáfora como no predicado, assim como afirmam Reinhart e Reuland (1993).
“Of course i’m happy”: an analysis of Animal farm (Orwell, 1945) and Fahrenheit 451 (Bradbury, 1953) dystopian modernity
Authors: Gonçalves Davi Silva 
Published: March 2018

*“É claro que sou feliz”: uma análise da modernidade distópica de Animal farm (Orwell, 1945) e Fahrenheit 451 (Bradbury, 1953)*Utopias e distopias, trazendo aos leitores possibilidades distintas de futuro, sempre nos ofereceram ferramentas para repensar a sociedade.Isto porque, apesar dos textos estarem inseridos em seus devidos contextos, eles são também empoderados com a possibilidade de dar forma à novos contextos – a literatura é informada e informa a realidade, operando como receptáculo e resposta à comoções sociais e políticas. Tendo isto em mente, este estudo analisa como Animal Farm (ORWELL, 1945) e Fahrenheit 451 (BRADBURY, 1953) reagem aos epistemes com os quais nós, leitores, viemos equipados. O que ambas novelas demonstram é que existe a possibilidade de aceitação e de subversão – isso quando estamos cientes que a segunda opção é de fato factível. Abordando questões como a alienação dos sujeitos e a ausência de suas habilidades críticas para interagir socialmente de maneira frutífera em vistas de alterar sua condição, as duas narrativas nos dão indicações da arena política para a qual discursos literários podem ser trazidos. Afinal, pensar politicamente acerca de produções literárias pode até ser uma opção, mas o fato de que a literatura consiste, por si só, em uma instituição política não é.
Outcome Analysis of the Flow Diversion with Pipeline Embolization Device for the Surgical Treatment of Unruptured Large and Giant Paraclinoid Carotid Aneurysms
Authors: Byvaltsev V. A. , Makhambetov Y. T. , Stepanov I. A. , Kaliyev A. B. , Akshulakov A. K. 
Published: March 2018

Background: Both the high frequency of recurrence of large or giant paraclinoid aneurysms (PA) of the internal carotid artery and the occurrence of intra- and postoperative complications, leading to unsatisfactory results of surgical treatment of this group of patients, make the stated problem urgent. Flow-diverter embolization devices are actively used in many large international neurosurgical centers for the treatment of cerebral aneurysms of different morphology, size, and localization. Currently, there are very few reports on the effectiveness of the use of flow diverting stents in the surgical treatment of large and giant PA of the internal carotid artery. The results of these studies are controversial and largely contradictory. Aim: Outcome analysis of the use of Pipeline embolization device (PED) for the surgical treatment of large and giant carotid PA. Methods: The study enrolled 37 patients (25 women, 12 men; mean age 51.7±10.7 years) who were divided into those treated with the PED alone versus those treated with the PED and concurrent coil embolization. The average follow-up period was 19.7±3.8 months. Results: In 56.7% of cases, PA caused the development of an insignificant neurological deficit (Modified Rankin Scale 1−2). In 18.9% of patients, PA provoked a gross neurologic deficit (MRS 3−5). 24.3% of patients with PA did not have any clinical-neurological manifestations. After the surgery, neurologic status improved in 32.4% of patients, remained the same — in 45.9% of cases, and the degree of neurologic deficit increased in 21.6%. PED procedure was performed in 70.2% of patients. In 29.7% of cases, the dislocation of large or giant PA of the internal carotid artery from the systemic blood stream was performed using PED and concurrent coil embolization. At the indicated period of patient observation, complete occlusion of large and giant carotid PA was achieved in 75.6% of cases, almost complete and partial occlusion — in 24.3%. The incidence of thromboembolic and hemorrhagic complications was 10.8% and 8.1%, respectively. Mortality rate among patients was 2.7%. Conclusions: The use of PED is an effective method for occluding large or giant PA of the internal carotid artery. Nevertheless, this method of endovascular treatment of PA is associated with a high complication incidence.
Multifocal Intraocular Lenses Clinical Assessment. Patient Selection for Multifocal Intraocular Correction
Authors: Morozova T. A. , Kerimov T. Z. 
Published: March 2018

There are some multufocal intraocular corrections particular qualities compared to monofocal correction. Therefore, the patient’s careful selection, detail preoperative diagnosis, accurate intraocular lens power calculation are necessary to get the optimal clinical results. There are some disadvantages in the postoperative period, such as the contrast sensitivities reduction, dysphotopsia, neuroadaptation. In addition multifocal IOLs are expensive. The clinical studies include evaluating of visual acuity for different distances, defocus curve, spectacle independence, contrast sensitivity, aberrometry data. Additionally, complications after multifocal IOLs implantation and the reasons of explantation are analyzed. This review includes 36 articles (34 clinical studies and 2 meta-analysis) of the following aspects of multifocal intraocular correction: contrast sensitivity, aberrometry analysis, pupil influence on the visual outcomes, postoperative complications, analysis of explantation reasons, preoperative patient’s selection for multifocal correction.
Clinical and Anamnestic, Immunological, Echographic, and Hysteroscopic Features of Chronic Endometritis Associated with Impaired Reproductive Function
Authors: Ishenko A. I. , Unanyan A. L. , Kogan E. A. , Demura T. A. , Kossovich J. M. 
Published: March 2018

Background: The widespread prevalence of infertility, the low effectiveness of assisted reproductive technologies (ART), and the high incidence of chronic endometritis (CE) in infertile women determine the relevance of the considered problem. The aim of the study was to determine the clinical and anamnestic, laboratory, and instrumental features of CE associated with infertility and unsuccessful IVF cycles in women of reproductive age. Materials and methods: The study enrollred 150 women of reproductive age with morphologically established CE (main group, n=120) and without CE (control group, n=30). A subgroup I of the main group included 64 patients with infertility and IVF failures, a subgroup II – 56 fertile women. In addition to anamnesis collection and identification of CE clinical features, all patients underwent infectious screening, immunological and immunohistochemical analysis, ultrasound examination of pelvic organs with dopplerometry, and office hysteroscopy. A comparative analysis of the data obtained from subgroups of the main group was conducted. Results: Histological study of endometrial pipelle-biopsy specimens on the 7−10th day of the cycle revealed CE in all patients of the main group. We found prevalence of mean duration of CE in the subgroup I relative to subgroup II ― 5.5±0.06 years and 2.4±0.07 years, respectively (p0.001). Infectious screening showed that 58 (90.6%) patients of the I subgroup had sterile endometrial seeding which was 16.9 times higher than in subgroup II (p0.0001). Immunological analysis determined the presence of AEAT in all patients of the subgroup I, 43 of which (67.2%) were above 265 U/ml, while 51 (91.1%) of subgroup II had no AEAT (p0.001). Immunohistochemical analysis of the endometrium on the 18th−24th day of the cycle established high expression of CD16 , CD20 , CD56 , and HLA-DRII in 58 (90.6%) patients of the subgroup I, whereas in 54 patients (96.4%) of II subgroup high expression of CD16 and CD20 with low amount of CD56- and HLA-DRII-positive cells was registered (p0.001). We determined prognostically significant clinical and anamnestic risk factors predisposing to the development of infertility in patients with CE (p0,05). We revealed certain echographic, dopplerometric, and hysteroscopic criteria of CE demonstrating the critical disruption of endometrial receptivity in infertile women. Conclusion: Most patients (90.6%) with infertility had autoimmune component of CE characterized by prolonged (more than 5 years) course, high serum level of AEAT, sterile endometrial crops, and high expression of inflammation markers CD16 , CD20 , CD56 and HLA-DRII .
Evaluation of antifibrotic effect of pirfenidone on human nasal mucosal fibroblast cell culture
Authors: At'kova E. L. , Krahoveckij N. N. , Yartsev V. D. , Subbot A. M. , Gabashvili A. N. , Rein D. A. , Nesterova T. V. 
Published: March 2018

Background: One of the main reasons of failure in surgical treatment of primary acquired nasolacrimal duct obstruction is excessive postoperative scarring of the dacryostomy. Despite the variety of procedures designed to prevent this, conflicting evidence of their efficacy and safety provide incentive for further research of antifibrotic therapeutics for adjunctive use in dacryocystorhinostomy.Aims: To evaluate the antifibrotic effect of pirfenidone on human nasal mucosal fibroblast cell culture.Materials and methods: Human nasal mucosal fibroblast cell cultures were established using samples obtained from 3 consecutive patients undergoing endonasal endoscopic dacryocystorhinostomy. Cell viability following treatment with pirfenidone was evaluated using MTS-assay. Induced inhibition of cell proliferation and migration was determined using scratch wound assay.Results: In this study pirfenidone exhibited a significant dose-dependent inhibiting effect on fibroblast proliferation with insignificant cell toxicity. Cell viability following 48 hours of incubation with various pirfenidone concentrations did not drop below 80%. The recovery of the fibroblast monolayer assessed after 24 hours of incubation was 84.88 and 8.26% in the control group, at a drug concentration of 0.15 mg/ml. Cell proliferation and migration was severely inhibited in cell culture specimens treated with pirfenidone compared to controls. The difference between groups was statistically significant (p=0,001).Conclusions: In our study pirfenidone demonstrated a pronounced antifibrotic effect. It is unlikely that inhibition of proliferation and migration of human nasal mucosal fibroblasts is mediated by cell toxicity of this medication as it was evaluated as low. Nonetheless an in vitro analysis is insufficient to judge pirfenidone’s efficacy and safety in preventing cicatrix formation following dacrycystorhinostomy.
A Phase I Trial of the IGF-1R Antibody Ganitumab (AMG 479) in Combination with Everolimus (RAD001) and Panitumumab in Patients with Advanced Cancer
Authors: Vlahovic Gordana , Meadows Kellen L. , Hatch Ace J. , Jia Jingquan , Nixon Andrew B. , Uronis Hope E. , Morse Michael A. , Selim M. Angelica , Crawford Jeffrey , Riedel Richard F. , Zafar S. Yousuf , Howard Leigh A. , O'Neill Margot , Meadows Jennifer J. , Haley Sherri T. , Arrowood Christy C. , Rushing Christel , Pang Herbert , Hurwitz Herbert I. 
Published: March 2018

Abstract

Purpose
This study evaluated the maximum tolerated dose or recommended phase II dose (RPTD) and safety and tolerability of the ganitumab and everolimus doublet regimen followed by the ganitumab, everolimus, and panitumumab triplet regimen.

Materials and Methods
This was a standard 3 + 3 dose escalation trial. Doublet therapy consisted of ganitumab at 12 mg/kg every 2 weeks; doses of everolimus were adjusted according to dose-limiting toxicities (DLTs). Panitumumab at 4.8 mg/kg every 2 weeks was added to the RPTD of ganitumab and everolimus. DLTs were assessed in cycle 1; toxicity evaluation was closely monitored throughout treatment. Treatment continued until disease progression or undesirable toxicity. Pretreatment and on-treatment skin biopsies were collected to assess insulin-like growth factor 1 receptor and mammalian target of rapamycin (mTOR) target modulation.

Results
Forty-three subjects were enrolled. In the doublet regimen, two DLTs were observed in cohort 1, no DLTs in cohort −1, and one in cohort −1B. The triplet combination was discontinued because of unacceptable toxicity. Common adverse events were thrombocytopenia/neutropenia, skin rash, mucositis, fatigue, and hyperglycemia. In the doublet regimen, two patients with refractory non-small cell lung cancer (NSCLC) achieved prolonged complete responses ranging from 18 to &gt;60 months; one treatment-naïve patient with chondrosarcoma achieved prolonged stable disease &gt;24 months. In dermal granulation tissue, the insulin-like growth factor receptor and mTOR pathways were potently and specifically inhibited by ganitumab and everolimus, respectively.

Conclusion
The triplet regimen of ganitumab, everolimus, and panitumumab was associated with unacceptable toxicity. However, the doublet of ganitumab at 12 mg/kg every 2 weeks and everolimus five times weekly had an acceptable safety profile and demonstrated notable clinical activity in patients with refractory NSCLC and sarcoma.

Implications for Practice
This trial evaluated the maximum tolerated dose or recommended phase II dose and safety and tolerability of the ganitumab and everolimus doublet regimen followed by the ganitumab, everolimus, and panitumumab triplet regimen. Although the triplet regimen of ganitumab, everolimus, and panitumumab was associated with unacceptable toxicity, the doublet of ganitumab at 12 mg/kg every 2 weeks and everolimus at five times weekly had an acceptable safety profile and demonstrated notable clinical activity in patients with refractory non-small cell lung cancer and sarcoma.
Minority Response to Ethnic Democracy
Authors: Dambrauskas Karolis 
Published: March 2018

This article focuses on the evolution of Polish minority responses to Lithuanian minority policies in the post-EU-accession period. State-minority conflicts in Lithuania have not generated violence or minority radicalization, despite continuing discontent among members of the state’s Polish minority (which constitutes Lithuania’s largest ethnic minority population) and the failure of the Lithuanian state to resolve the causes of discontent. Employing Smooha’s concept of ethnic democracy, the article addresses this puzzle through an ethnographic exploration of the views held by members of the Polish minority about the Lithuanian state’s policies of nation-building. The findings reveal a diverse set of critical perceptions among Poles in Lithuania, which emphasize the ineffectiveness of state policies in addressing minority needs. However, a shared perception of threat from Russia, generated after the Russian annexation of Crimea in 2014, helps to sustain the regime’s stability and its strategy of stalling the resolution of minority concerns.
Official Statistics and Big Data
Authors: Giczi Johanna , Szőke Katalin 
Published: March 2018

More than five years ago Eurostat started a project with the aim to 'tame' sources of Big Data in a way that they can be incoporated into official statistical systems. In order to solve the problems a statistician might be faced with during the official statistical application of Big Data, first of all, we give an overview of traditional data collection, and then point to the differences one has to face when dealing with Big Data. We introduce common sources of data (traditional, administrative) and highlight the ways huge sets of data are different compared to them. Next, we discuss characteristics of Big Data versus traditional statistical methods based on the qualitative criteria of official statistics, and we also elaborate on the problems of analysing Big Data. Finally, we provide a list of use cases for Big Data in official statistical data collections.
Primary intradural neuroendocrine tumour of spine: a rare pathology
Authors: Gupta Vipin K. , Latawa Archit , Kalra Gagan , Radotra Bishan D. 
Published: March 2018

Neuroendocrine tumour in central nervous system is a very rare pathology. We hereby report a primary intradural neuroendocrine tumour, second to the only other case reported in literature till now as per the best of our knowledge. The tumour was completely intradural, spanning across five segments in the lumbar spine and no primary tumour could be detected elsewhere in body. The patient underwent surgery followed by radiotherapy and showed symptomatic relief. This case report focusses on compiling the available literature on spinal carcinoids (both primary and metastatic) and discussing the relevant investigations and available treatment options for the same.
Chikungunya on the move- reflection from Pakistan
Authors: Bukhari Syeda Rohma , Mahmood Syed Uzair , Jamal Ayesha Marium , Syed Maryam Jamil , Bukhari Syeda Ifrah 
Published: March 2018

Chikungungya is not a recently discovered disease but it came into lime light again when three of the seven continents suffered a recent outbreak. The disease, its virus and the vector- the Aedes aegypti mosquito, were first described by Marion Robinson and William Hepburn Russell Lumsden in 1955. Out of fever, maculo-papular rash and joint paint; severe arthralgia dominates the symptoms of chikungunya, and that is why the word itself, translated into the language of is origin i.e. Makonde, means to become distorted. Many research studies have been conducted to find a vaccine. Lack of awareness in Pakistan and misdiagnosis has led consequently to an alarming number of cases over all in Pakistan but especially the Malir district of Karachi. Efforts to take pre cautions by increasing awareness about the disease and preventive measures such as eliminating breeding sites and avoiding mosquito bites can easily contain spread of disease.