bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can a 2-Day Course Teach Orthopaedic Surgeons Rotational Flap Procedures? An Evaluation of Data From the Nepal SMART Course Over 2 years
Authors: Challa Sravya , Conway Devin , Wu Hao-Hua , Bisht Rishi , Sherchan Binod , Lamichhane Arjun , Shearer David W. , Terry Michael , Gillenwater Justin 
Published: September 2018

Introduction:
Traumatic lower extremity injuries requiring multidisciplinary treatment pose a challenge in low- and middle-income countries, where access to specialists may be limited. The surgical management and reconstructive training (SMART) course teaches orthopaedic surgeons muscle and fasciocutaneous flap procedures to address this scarcity. The purpose of this study is to assess the effectiveness of the SMART course in improving competency and comfort in performing common lower extremity flap procedures among participants.

Methods:
Sixty-four orthopaedic surgeons from different regions of Nepal and Bhutan participated in the Nepal SMART course in 2016 and 2017. A competency test—consisting of questions from US in-training plastic and orthopaedic surgery examinations—was administered to attendees before and after the course. Thirty-two participants from 2016 were asked to rate their comfort level in performing flap procedures both pre- and postcourse.

Results:
Overall competency test scores, as well as scores in the plastic surgery section, increased significantly after the course (P < 0.01). The precourse competency test scores were higher in 2016 compared with 2017 (P = 0.02). There was a higher increase in overall competency test scores after the course in 2016 compared with 2017 (P = 0.03). The procedure comfort levels reported by attendees increased for all flaps (P < 0.01).

Conclusions:
These results demonstrate the ability of the SMART course to improve the competency and comfort levels of orthopaedic surgeons in performing common lower extremity flap procedures. Despite the differences in years in practice and previous experience in performing flaps, the course yielded significantly better results in 2017 compared with 2016, showing that the implementation of the course has been improving.
Loss of Midline Function in Brachial Plexus Birth Palsy Patients
Authors: Abzug Joshua M. , Wyrick-Glover Theresa O. , Case Alexandria L. , Zlotolow Dan A. , Kozin Scott H. 
Published: September 2018

Background:
Loss of midline function impairs the child’s ability to perform certain activities of daily living such as dressing, buttoning, and perineal care. The purpose of this study was to assess brachial plexus birth palsy (BPBP) patients with loss of midline function with respect to etiology and treatment.

Methods:
A retrospective review of all BPBP patients with loss of midline function was performed. The modified Mallet scale was used with internal rotation assessed via hand on spine and hand to belly. Demographics, extent of BPBP, prior surgical intervention, procedure(s) performed to correct the loss of midline function, complications, and outcomes were assessed.

Results:
In total, 20 patients were identified with loss of midline function as defined by the inability to reach midline and touch their umbilicus. Nineteen patients had previously undergone tendon transfers about the shoulder with or without arthroscopic capsular release to improve external rotation. After the initial surgery, modified Mallet scores improved 1 grade for abduction, hand to mouth, hand to neck, and external rotation without altering the hand to spine category. However, the internal rotation category (hand to umbilicus) decreased from an average 2.71 preoperatively to an average 2.15 postoperatively. Nine patients underwent a derotational humeral osteotomy to improve midline function. The average correction of internal rotation was 47.8 degrees (range, 20 to 85 degrees). After this surgery, modified Mallet scores remained unchanged for hand to spine; however, the scores improved back to 2.7 for the internal rotation category. Two complications were noted including 1 plate fracture and 1 fracture through a screw hole.

Conclusions:
BPBP patients who undergo surgical procedures to improve shoulder external rotation and/or obtain joint reduction may inadvertently lose midline function. Derotational humeral osteotomy can effectively restore midline function, which is needed to perform activities of daily living. Surgical procedures to improve external rotation should be performed in a manner that minimizes limitation of midline functions.

Level of Evidence:
Level III—therapeutic.
Financial Analysis of Closed Femur Fractures in 3- to 6-Year-Olds Treated With Immediate Spica Casting Versus Intramedullary Fixation
Authors: Lewis Robert B. , Hariri Omar , Elliott Marilyn E. , Jo Chan-Hee , Ramo Brandon A. 
Published: September 2018

Background:
Health care in America continues to place more importance on providing value-based medicine. Medicare reimbursements are increasingly being tied to this and future policy changes are expected to reinforce these trends. Recent literature has shown pediatric femur fractures in preschool-age children have equivalent clinical and radiographic outcomes when treated with spica casting or flexible intramedullary nails (IMN). We compared hospital care statistics including charges for nonoperative versus operative treatment for closed femur fractures in 3- to 6-year-olds.

Methods:
An IRB-approved retrospective chart review was performed of 73 consecutive 3- to 6-year-olds treated at a regional level 1 pediatric hospital from January 1, 2009 to December 31, 2013 with an isolated, closed femoral shaft fracture. Exclusion criteria included open fractures, bilateral injury, and polytrauma. Immediate spica casting was performed in the Emergency Department or Anesthesia Procedure Unit versus IMN in the operating room.

Results:
A total of 41 patients were treated with spica casting and 32 patients were treated operatively with flexible IMNs; 3 patients failed nonoperative care. After analysis of final treatment groups, significant differences included age at injury: 3.7 years for cast versus 5.3 years for IMN (P<0.001), time to discharge 21 versus 41 hours (P<0.001), 3.2 versus 4.4 clinic visits (P<0.001), follow-up 3.5 versus 9.4 months (P<0.001). Orthopedic surgeon charges were $1500 for casted patients versus $5500 for IMN (P<0.001). Total hospital charges were $19,200 for cast versus $59,700 for IMN (P<0.001). No difference was found between clinic charges or number of radiographs between groups. In total, 76% of cast group were discharged <24 hours from admission versus 8.6% in operative group. In the operative group, 83% had implant removal with no statistically significant charge difference between those who had implant removal versus retention.

Conclusions:
Treatment of pediatric femur fractures in 3- to 6-year-olds with IMN is associated with longer hospital stays, significantly greater hospital charges, longer follow-up and more clinic visits compared with spica casting. These findings are at odds with previous literature showing shorter hospital stays and decreased cost with nailing compared to traction and casting. This shows a clear difference between 2 treatments that yield similar clinical and radiographic outcomes.

Level of Evidence:
Level III—retrospective comparative study.
Removal of Metaphyseal Screw Only After Hemiepiphysiodesis Correction of Coronal Plane Deformities Around the Knee Joint: Is This a Safe and Advisable Strategy?
Authors: Keshet Doron , Katzman Alexander , Zaidman Michael , Eidelman Mark 
Published: September 2018

Purpose:
Correcting lower limb angular deformities in the skeletally immature patient with guided growth is a very common procedure. Using an 8-plate construct to produce reversible hemiepiphysiodesis allows correction of the mechanical axis of the limb. It has become routine strategy to remove only the metaphyseal screw from the 8-plate construct after desired correction is achieved, in order to ease its reinsertion in case of deformity recurrence. In this study, we evaluated the efficacy and safety of this technique.

Methods:
We reviewed the results of 80 patients (133 limbs) who were treated by guided growth using 8-plate hemiephisiodesis around the knee. After achievement of the correction goal, both screws and plate were removed in 78 limbs while only the metaphyseal screw was removed in 55 limbs.

Results:
The mean age of patient was 8.9 years at the time of surgery. Within the group whose metaphyseal screw was removed, 12 limbs showed radiographic signs of deformity recurrence and underwent reinsertion of the metaphyseal screw. In 9 of the cases of metaphyseal screw reinsertion, the plate or its location had to be changed (mean follow-up after screw removal was 14 mo). There were 2 cases where leaving the plate with an epiphyseal screw caused a radiographic bone bar and undesired clinical growth arrest.

Conclusions:
On the basis of our experience, leaving the 8-plate construct with an epiphyseal screw in place exposes the patient to risks of bony bar, growth arrest, and an additional surgery for hardware removal. The majority of 8-plate constructs are not suitable for reinsertion of the metaphyseal screw.
Sagittal Imbalance Does Not Influence Cup Anteversion in Total Hip Arthroplasty Dislocations
Authors: Haws Brittany E. , Khechen Benjamin , Patel Dil V. , Louie Philip K. , Iyer Sravisht , Cardinal Kaitlyn L. , Guntin Jordan A. , Singh Kern 
Published: September 2018

Study Design:
Retrospective Cohort.

Summary of Background Data:
Studies have shown that lumbar fusion procedures are associated with an increased risk of total hip arthroplasty (THA) dislocation. Some have speculated that the increased risk of dislocation is caused by mispositioning of the acetabular component because of spinal sagittal imbalance. Unfortunately, the exact relationship between spinal sagittal balance and cup orientation is unknown.

Objective:
The objective of this study was to investigate the effect of spinal sagittal alignment on cup anteversion in THA dislocation.

Methods:
Patients that suffered a THA dislocation were retrospectively identified. Cross-table lateral hip radiographs were used to measure cup anteversion with normal acetabular anteversion defined as 15±10 degrees. Lateral lumbar spine radiographs were used to measure lumbar lordosis (LL), pelvic incidence (PI), pelvic tilt, and sacral slope. Normal sagittal balance was defined as a PI-LL difference of <10 degrees. The association between sagittal balance and THA characteristics was assessed using Pearson correlation coefficient, χ2 analysis, and independent t tests.

Results:
A total of 29 patients had full radiographic imaging. Among these patients, 62.1% dislocated following a primary THA and 37.9% following a revision THA. Abnormal spinal sagittal balance was identified in 20 patients (69.0%). Eight (27.6%) patients had undergone spinal fusion prior to THA. Abnormal cup anteversion was demonstrated in 51.7% of all patients. Presence of a spinal fusion was not associated with cup anteversion, sagittal balance, or time to dislocation. Sagittal balance was not associated with direction of dislocation, time to dislocation, or cup anteversion.

Conclusions:
A majority of patients with a THA dislocation demonstrated abnormal sagittal balance. However, sagittal balance was not associated with acetabular cup anteversion. As such, the relationship between spinal deformity and dislocation rates after THA may not be because of inaccurate cup orientation.
Effect of Cervical Decompression Surgery on Gait in Adult Cervical Spondylotic Myelopathy Patients
Authors: Haddas Ram , Lieberman Isador , Arakal Raj , Boah Akwasi , Belanger Theodore , Ju Kevin 
Published: September 2018

Study Design:
This is a prospective cohort study.

Objective:
To evaluate the effect of cervical decompression surgery on the biomechanics of the spine and lower extremities in cervical spondylotic myelopathy (CSM) patients and compare with asymptomatic controls.

Summary of Background Data:
Difficulties with balance and gait are one of the most common manifestations of CSM. Patients with CSM have a slower gait speed, prolonged double support duration, and reduced cadence compared with healthy controls. Surgical decompression was found to improve clinical outcomes, but conflicting results are noted when examining function.

Materials and Methods:
In total, 25 subjects with symptomatic CSM underwent clinical gait analysis performed a week before (pre) and 3 months after the surgery (post). Clinical gait analysis was performed on 30 matched asymptomatic controls as well. Spine and lower extremity kinematics, spatiotemporal parameters, and clinical outcome were measured.

Results:
CSM patients demonstrated slower walking speed (P=0.006), reduced cadence (P=0.001), longer step time (P=0.013) wider step width (P=0.001), greater ankle range of motion (ROM) (P=0.019), less hip ROM (P=0.050), increased pelvis (P=0.001), and lumbar spine (P=0.049) ROM compared with controls. Postoperatively CSM patients demonstrated a faster walking speed (P=0.002), increased cadence (P=0.029), longer step length (P=0.015), narrower step width (P=0.004), greater knee (P=0.043), and hip ROM (P=0.007), less pelvis (P=0.002), lumbar spine (P=0.035), and cervical spine (P=0.044) ROM, and improved clinical outcomes (neck pain disability index questionnaire, oswestry disability index, and visual analog scale; P=0.001) compared with their preoperative values. Postsurgical CSM patients did not present with any differences compared with controls, beside pelvis ROM (P=0.019).

Conclusions:
Preoperatively, CSM patients clearly showed altered gait parameters compared with controls. However, after cervical decompression surgery, CSM patients exhibited improved gait pattern, spatiotemporal parameters, spine and lower extremity ROM, as well as patient-reported outcomes. Postoperatively, CSM patients did not show major differences in gait when compared with matched asymptomatic controls.
Patient-specific Rods for Surgical Correction of Sagittal Imbalance in Adults
Authors: Solla Federico , Barrey Cédric Y. , Burger Evalina , Kleck Christopher J. , Fière Vincent 
Published: September 2018

Study Design:
This was an innovative concept and a preliminary prospective series.

Objective:
The aim of this study was to present the concept and the technical aspects of patient-specific rods (PSR), and compare preoperative and postoperative sagittal parameters (after PSR implantation), with a special focus on the difference pelvic incidence (PI)—lumbar lordosis (LL).

Background:
Despite established techniques for planning and proven correlations between quality of life and sagittal alignment, some patients do not achieve optimal radiologic outcomes after surgery and are still hypolordotic and imbalanced. We hypothesize that the use of PSR could improve the correspondence between planning and surgical realization.

Methods:
The planning was based on spinopelvic parameters evaluated on a full-spine x‐ray. The surgical procedure including osteotomies was simulated using a dedicated program to reach the following objectives: PI-LL<10 degrees, a pelvic tilt <20 degrees, and sagittal vertical axis <50 mm. From the virtually corrected spine, the rod curvature and length were defined. Two PSRs were thus precisely manufactured and bent to this specification. Adults with degenerative spinal disorders requiring a construct ≥5 levels were implanted with PSR and prospectively included. We compared ratios through the χ2 test.

Results:
A total of 60 patients (mean age of 64.4 years old; range, 34–83) were included. Follow-up was carried out over a period of 1 year. Average pedicle screws construct was of 6.4 levels (range, 5–9). Eight patients underwent a pedicle subtraction osteotomy. PI-LL was <10 degrees at baseline in 29/60 patients, and at follow-up in 50/60 (odds ratio=5, P=E-5).

Conclusions:
The ratio of patients with optimal PI-LL improved significantly from PSR implantation. In comparison with published data for conventional surgery, patients implanted with PSR were 2.6 times more likely to be optimally corrected. The expected benefits of PSR include the optimal execution of the plan, decreased mechanical complications, and reduced operating time, no longer requiring the bending of rods during surgery. A randomized trial on sagittal correction using PSR is ongoing.
Safety and Efficacy of Cabozantinib for Metastatic Nonclear Renal Cell Carcinoma
Authors: Prisciandaro Michele , Ratta Raffaele , Massari Francesco , Fornarini Giuseppe , Caponnetto Salvatore , Iacovelli Roberto , De Giorgi Ugo , Facchini Gaetano , Scagliarini Sarah , Sabbatini Roberto , Caserta Claudia , Peverelli Giorgia , Mennitto Alessia , Verzoni Elena , Procopio Giuseppe 
Published: September 2018

Objective:
The activity of cabozantinib in nonclear cell histologies has not been evaluated.

Materials and Methods:
Data were collected across 24 Italian hospitals. Patients were aged 18 years and older with advanced nonclear cell renal cell carcinoma (RCC), with an Eastern Cooperative Oncology Group Performance Status 0 to 2, who had relapsed after previous systemic treatments for metastatic disease. Cabozantinib was administered orally at 60 mg once a day in 28 days cycles. Dose reductions to 40 or 20 mg were made due to toxicity. Adverse events (AEs) were monitored using CTCAE version 4.0.

Results:
Seventeen patients were enrolled. Three (18%) patients were diagnosed type I papillary RCC, 9 (53%) type II papillary, 3 (18%) chromophobe, and 2 (11%) with Bellini duct carcinoma. In total, 11 patients started with 60 mg. Six patients started a lower dose of 40 mg. Median progression-free survival was 7.83 months (0.4 to 13.4 mo), while median overall survival was not reached but 1-year overall survival was about 60%. Six patients (35%) experienced a partial response to treatment and 6 patients (35%) showed a stable disease. In the remaining 5 (30%), we observed a progressive disease. Grade 3 and 4 AEs were observed in 41% of patients. Among 20 patients, only 1 (6%) discontinued treatment due to AEs. Asthenia (41%), diarrhea (35%), aminotransferase increasing (35%), mucosal inflammation (35%), hand and foot syndrome (24%), and hypothyroidism (24%) were the most frequently AEs.

Conclusions:
Our data showed that, cabozantinib is a active and feasible treatment in patient with nonclear cell RCC.
Differential Outcomes Among Immunosuppressed Patients With Merkel Cell Carcinoma
Authors: Cook Maclean , Baker Kelsey , Redman Mary , Lachance Kristina , Nguyen Macklin H. , Parvathaneni Upendra , Bhatia Shailender , Nghiem Paul , Tseng Yolanda D. 
Published: September 2018

Objectives:
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer with higher incidence among whites, elderly, and immunosuppressed patients. Although immunosuppressed MCC patients are at higher risk of recurrence and MCC-related death, it is unknown whether immunosuppression type is associated with differential outcomes.

Materials and Methods:
We retrospectively evaluated 89 nonmetastatic MCC patients with a diagnosis of chronic immunosuppression. Immunosuppression was categorized as chronic lymphocytic leukemia (31% of cohort), other hematologic malignancies (18%), solid organ transplant (21%), autoimmune disease (21%), and human immunodeficiency virus acquired deficiency syndrome (8%). Progression-free survival (PFS) and MCC-specific survival (MSS) were estimated with the cumulative incidence function. Overall survival (OS) was estimated by the Kaplan-Meier method.

Results:
With a median follow-up of 52 months, 53 deaths occurred (42 from MCC, 7 unknown, and 4 non-MCC). Two-year PFS, MSS, and OS were 30%, 55%, and 52%, respectively. Human immunodeficiency virus/acquired deficiency syndrome and solid organ transplant patients were diagnosed with MCC at a younger age (median 55 and 59 y, respectively) and with more advanced stage disease compared with other immunosuppressed subgroups. PFS did not significantly differ among the 5 immunosuppression subgroups (P=0.30), but significant differences were observed in MSS and OS (both P=0.01). Controlling for potential confounders for OS, including age and stage, immunosuppression type was still significantly associated with risk of death (P=0.01).

Conclusions:
Among immunosuppressed MCC patients, recurrent MCC is the major cause of mortality. The risk of death from MCC differs among immunosuppression types, suggesting important biological differences in host-tumor immune interactions.
A Simplified Risk Stratification Method for Women With Stage I Endometrial Carcinoma
Authors: Elshaikh Mohamed A. , Modh Ankit , Sakr Sharif , Shrestha Resha , Burmeister Charlotte , Ali-Fehmi Rouba , Hanna Rabbie K. 
Published: September 2018

Objectives:
Available risk stratification methods for women with endometrial carcinoma are controversially defined. We sought to develop a simplified and an individualized prognostic index for cancer recurrence in women with International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial carcinoma, solely of endometrioid histology.

Materials and Methods:
We identified 976 women who underwent a hysterectomy and did not receive any adjuvant therapy. Cox proportional hazards model was used to identify independent predictors of recurrence. Prognostic groups were created based on the number of independent predictors of recurrence (0, 1, or 2 or 3 risk factors). These groups were then validated using a separate cohort of 611 women treated at another academic institution. The model’s performance for predicting cancer recurrence was measured by the concordance probability estimate along with a 95% confidence interval.

Results:
Median follow-up was 65 months. The final recurrence model included 3 risk groups based on 3 independent predictors of recurrence (tumor grade 2 or 3, the presence of lymphovascular space invasion and stage IB). Five-year recurrence rates were 4%, 16%, and 44% for groups 0, 1, and 2 or 3, respectively. The performance of the model was very good with a concordance probability estimate of 0.72 and 0.80 for the development and validation cohorts, respectively.

Conclusions:
On the basis of 3 well-known prognostic factors, we have developed and externally validated a simplified prognostic model that accurately predicts cancer recurrence in women with stage I endometrial carcinoma. This simplified predictive tool may be helpful in estimating individualized risk of recurrence and guide counseling with regard to adjuvant treatment.