bluuebunny/crossref_metadata_2025_split huggingface dataset:
The multiple mediating effects of illness perceptions and coping strategies on the relationship between physical symptoms and depressive symptoms in patients with heart failure
Authors: Chen Cancan , Fang Wenjie , An Yan , Wang Lyu , Fan Xiuzhen 
Published: July 2019

Background: Depressive symptoms are prevalent and cause poor health outcomes in patients with heart failure. Studies show that the physical symptoms of heart failure are associated with depressive symptoms. However, little is known about the underlying mechanisms of this relationship. Aims: The purpose of our study was to examine the associations between physical symptoms, illness perceptions, coping strategies and depressive symptoms and to test the multiple mediation effects of illness perceptions and coping strategies on the relationship between physical symptoms and depressive symptoms in patients with heart failure. Methods: Physical symptoms, illness perceptions, coping strategies and depressive symptoms were assessed using self-reported questionnaires among 302 patients (64.2±11.9 years, 54% male) with heart failure in a tertiary general hospital. A serial multiple mediation model was tested using the PROCESS macro for SPSS. Results: Depressive symptoms were positively correlated with physical symptoms ( r=0.487, p<0.01), illness perceptions ( r=0.499, p<0.01) and acceptance–resignation coping ( r=0.580, p<0.01). The relationship between physical symptoms and depressive symptoms was mediated by illness perceptions (indirect effect: 0.036, confidence interval (0.014, 0.059)) and by acceptance-resignation (indirect effect: 0.034, confidence interval (0.019, 0.053)), respectively, and by these two in serial (indirect effect: 0.021, confidence interval (0.013, 0.033)). Conclusion: Patients with heart failure who have more physical symptoms are vulnerable to the development of depression. Healthcare providers should implement interventions focused on changing illness perceptions and reducing acceptance–resignation coping to relieve depressive symptoms.
Targeting CDK9 and MCL-1 by a new CDK9/p-TEFb inhibitor with and without 5-fluorouracil in esophageal adenocarcinoma
Authors: Tong Zhimin , Mejia Alicia , Veeranki Omkara , Verma Anuj , Correa Arlene M. , Dokey Rashmi , Patel Viren , Solis Luisa Maren , Mino Barbara , Kathkuda Riham , Rodriguez-Canales Jaime , Lin Steven H. , Krishnan Sunil , Kopetz Scott , Blum Mariela , Ajani Jaffer A. , Hofstetter Wayne L. , Maru Dipen M. 
Published: July 2019

Background: CDK9 inhibitors are antitumorigenic against solid tumors, including esophageal adenocarcinoma (EAC). However, efficacy of a CDK9 inhibitor combined with 5-fluorouracil (5-FU) and target proteins that are targeted by these agents in EAC are unknown. Methods: The anti-EAC efficacy of a new CDK9 inhibitor, BAY1143572, with and without 5-FU was assessed in vitro and in xenograft models in athymic nu/nu mice. Synergy between BAY1143572 and 5-FU in inhibiting cell proliferation was analyzed by calculating the combination index using CompuSyn software. Potential targets of BAY1143572 and 5-FU were identified by reverse-phase protein array. The effects of BAY1143572 and 5-FU on MCL-1 in vitro were analyzed by Western blotting, quantitative real-time polymerase chain reaction, and chromatin immunoprecipitation assay. MCL-1 protein expression in tumors from patients with locoregional EAC treated with chemoradiation and surgery was assessed by immunohistochemistry. Results: BAY1143572 had dose-dependent antiproliferative and proapoptotic effects and demonstrated synergy with 5-FU against EAC in vitro. The median volumes of FLO-1 and ESO-26 xenografts treated with 5-FU plus BAY114352 were significantly smaller than those of xenografts treated with either agent alone ( p < 0.05). BAY1143572 downregulated MCL-1 by inhibiting HIF-1α binding to the MCL-1 promoter. 5-FU enhanced BAY1143572-induced MCL-1 downregulation and stable MCL-1 overexpression reduced the apoptosis induced by BAY1143572 and 5-FU in vitro. High patients’ tumor MCL-1 expression was correlated with shorter overall and recurrence-free survival. Conclusions: BAY1143572 and 5-FU have synergistic antitumorigenic effects against EAC. MCL-1 is a downstream target of CDK9 inhibitors and a predictor of response to neoadjuvant chemoradiation in EAC.
Shared and unique risk factors for depression and diabetes mellitus in a longitudinal study, implications for prevention: an analysis of a longitudinal population sample aged ⩾45 years
Authors: Chireh Batholomew , D’Arcy Carl 
Published: July 2019

Objective: The objective of this study was to examine shared and unique risk factors for incident depression and diabetes mellitus in a national longitudinal population-based survey. Methods: Canadian National Population Health Survey (NPHS) longitudinal study was used. A subsample of the initial NPHS sample ( n = 4845), free of depression or diabetes mellitus at baseline was tracked over a 10-year period. Univariate and multivariate modified Poisson regression models were used to estimate the relative risk (RR). Stratified analyses by sex were conducted to measure its moderating role. The goodness-of-fit of the various models was tested. Results: The cumulative incidence rate of major depressive disorder and incident diabetes mellitus at 10-year follow-up were 4.1% and 10.1% respectively. Hypertension, daily smoking, physical inactivity and being overweight or obese were shared risk factors for major depressive episode and diabetes mellitus. Being female, family stress, traumatic events, having any chronic disease or heart disease were uniquely associated with depression while increasing age and ethnicity (non-white) were unique risk factors for diabetes mellitus. Also, underweight, family stress, chronic disease, and heart disease were risk factors for major depressive disorder in both sexes. Six risk factors, age, ethnicity (non-white), high blood pressure, daily smoking, physical inactivity, and body mass index were associated with incident diabetes mellitus in both sexes. Conclusion: We found common risk behaviors/conditions not specific to either diabetes mellitus or depression. These risks have also been implicated in the development of a variety of chronic diseases. These findings underline the importance of public health prevention programs targeting generic risk behaviors.
Clinical Outcomes of Inside-Out Meniscal Repair According to Anatomic Zone of the Meniscal Tear
Authors: Cinque Mark E. , DePhillipo Nicholas N. , Moatshe Gilbert , Chahla Jorge , Kennedy Mitchell I. , Dornan Grant J. , LaPrade Robert F. 
Published: July 2019

Background: There is significant discrepancy in the reported vascularity within the meniscus, and a progressively diminishing blood supply may indicate a differential healing capacity of tears that is dependent on the affected meniscal zone. Purpose: To examine the outcomes after inside-out meniscal repair in all 3 meniscal vascularity zones. Study Design: Cohort study; Level of evidence, 3. Methods: Patients were included if they underwent inside-out meniscal repair by a single surgeon between 2010 and 2014 and had a minimum 2-year follow-up. Patients were divided into 3 groups based on the meniscal tear location (red-red, red-white, and white-white zones) as determined during an intraoperative assessment. Patient-reported outcome scores were obtained at final follow-up. Results: A total of 173 patients (mean age, 33.6 ± 14.3 years) were included, with a mean follow-up of 2.9 ± 0.9 years. All patients demonstrated significant improvements with inside-out meniscal repair from preoperatively to postoperatively, regardless of the meniscal tear location. Patients who underwent meniscal repair in the red-red and red-white zones had significantly increased postoperative Tegner, Lysholm, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores compared with patients who underwent meniscal repair in the white-white zone ( P < .05). Patients who underwent acute repair (≤6 weeks) demonstrated significantly higher improvements on the Tegner activity scale (acute: 5.8 ± 2.2; chronic: 4.6 ± 2.2; P = .001) and Lysholm score (acute: 85.6 ± 13.3; chronic: 80.8 ± 13.5; P = .025) compared with patients treated beyond 6 weeks from injury, regardless of the meniscal tear zone. Patients with grade IV femoral condyle chondral lesions at the time of surgery had significantly inferior outcomes compared with patients with grade I through III chondral lesions, regardless of the meniscal tear zone. Three patients (1.7%) subsequently underwent revision inside-out repair, and 3 (1.7%) underwent partial meniscectomy. Conclusion: Patients who underwent inside-out meniscal repair demonstrated significant improvements on subjective outcome measures at a minimum 2-year follow-up, regardless of the meniscal tear zone. Inside-out meniscal repair is recommended for potentially reparable meniscal tears in all 3 vascular zones; however, improved outcomes can be achieved when performed acutely, in the absence of full-thickness femoral condyle chondral injuries, and in the red-red and red-white zones.
Impact of metformin on disease control and survival in patients with head and neck cancer: A retrospective cohort study
Authors: Lee Daniel J. , McMullen Caitlin P. , Foreman Andrew , Huang Shao Hui , Lu Lin , Xu Wei , de Almeida John R. , Liu Geoffrey , Bratman Scott V. , Goldstein David P. 
Published: July 2019

Objective A number of in vitro and clinical studies have suggested potential antineoplastic effects of metformin. The impact of this medication on outcomes in head and neck cancer is less clear. Our aim was to determine the effect of metformin on outcomes within our large cohort of head and neck cancer patients with Type II Diabetes (T2DM). Study design Retrospective cohort study. Setting Tertiary Cancer Centre. Subjects and methods A retrospective review of individuals with head and neck squamous carcinoma (HNSCC) and T2DM between January 2005 and December 2011 at Princess Margaret Cancer Centre was conducted. Medication history was obtained from surveys at initial presentation and electronic medical record review. Using Cox regression analyses, the association between metformin use and local, regional and distant failures was explored. Subgroup analyses were conducted for oral cavity, oropharynx and larynx. Results A total of 329 HNSCC patients with T2DM were identified, including 195 metformin users and 134 non-metformin users. Patients were well-matched in terms of clinical, pathologic, and treatment factors. No difference in local, regional, or distant failure was observed between diabetic metformin users and diabetic non-metformin users for the entire cohort or within subgroup analysis for subsite. No difference between the two groups was observed for overall survival, recurrence-free survival, and disease-specific survival at 5 years. Conclusion No association between metformin use and oncologic outcomes were observed in this large cohort of HNSCC patients. Multicenter, prospective studies may be needed to verify previous studies identifying a potential anti-neoplastic effect of this medication.
Intestinal barrier dysfunction in severe burn injury
Authors: He Wen , Wang Yu , Wang Pei , Wang Fengjun 
Published: July 2019

AbstractSevere burn injury is often accompanied by intestinal barrier dysfunction, which is closely associated with post-burn shock, bacterial translocation, systemic inflammatory response syndrome, hypercatabolism, sepsis, multiple organ dysfunction syndrome, and other complications. The intestinal epithelium forms a physical barrier that separates the intestinal lumen from the internal milieu, in which the tight junction plays a principal role. It has been well documented that after severe burn injury, many factors such as stress, ischemia/hypoxia, proinflammatory cytokines, and endotoxins can induce intestinal barrier dysfunction via multiple signaling pathways. Recent advances have provided new insights into the mechanisms and the therapeutic strategies of intestinal epithelial barrier dysfunction associated with severe burn injury. In this review, we will describe the current knowledge of the mechanisms involved in intestinal barrier dysfunction in response to severe burn injury and the emerging therapies for treating intestinal barrier dysfunction following severe burn injury.
Impact of Initiating Screening Programs on Referral and Management of Cervical Cancer in Tanzania
Authors: Sedani Ami , Soliman Amr S. , Msami Khadija , Msemo Diwani , Mwaiselage Julius , Schmid Kendra , Kahesa Crispin 
Published: July 2019

PURPOSE We investigated the impact of screening rural patients on referral and management of cervical cancer in Tanzania. METHODS After reviewing more than 10,000 medical records of patients with cervical cancer who visited Ocean Road Cancer Institute (ORCI) from 2005 to 2014, 108 patients were from the rural communities of Bagamoyo and Chalinze. We abstracted demographic, clinical, and lifestyle factors and linked the data set to databases of all 1,151 patients who visited the Bagamoyo screening clinic from 2011 to 2014 and 1,273 patients who visited the Chalinze screening clinic from 2012 to 2014. RESULTS After initiation of the rural screening clinics, difference in duration from diagnosis to prescribed treatment increased from 50.5 to 88 days ( P = .030), and duration from referral to treatment increased from 38.6 to 101.3 days ( P = .041). Proportion of patients who received combination chemoradiotherapy increased from 34.3% to 69% ( P = .001) and completion of treatment decreased from 94.4% to 72.41% ( P = .002) after initiation of the ORCI screening clinic. Patients who visited Muhimbili National Hospital had significantly shorter periods between referral and prescribed treatment than patients who did not use the Muhimbili National Hospital (mean ± standard deviation, 49.4 ± 128.8 and 112.1 ± 195.31 days, respectively; P = .010). Patients who were treated at ORCI had significantly shorter periods between diagnosis and referral to treatment (mean ± standard deviation, 31.4 ± 62.35 and 36.4 ± 121.79 days, respectively; P = .005). CONCLUSION Future research should focus on investigating barriers to seeking cancer care, benefits of chemoradiotherapy in this population considering the change in prescribed treatment, and time until diagnosis and treatment. Prescription of complex treatments that require more visits to treatment centers may also contribute to decline in completion of treatment.
The experience of financial burden for patients with multimorbidity: A protocol for a systematic review of qualitative research
Authors: Larkin James , Foley Louise , Smith Susan M. , Harrington Patricia , Clyne Barbara 
Published: July 2019

Introduction: Multimorbidity is increasingly important due to its high disease burden, prevalence and related high healthcare utilisation. For patients, there is also a high financial burden due to direct and indirect costs arising from their multimorbidity. It is unclear how this financial burden affects patients. This study aims to synthesise qualitative evidence exploring the experience of financial burden from the perspective of patients with multimorbidity. Methods: The review will be reported using the ENTREQ guidelines. A systematic search of Lilacs, PubMed, CINAHL, EMBASE, PsycINFO, and Applied Social Sciences Index and Abstracts will be conducted using a predefined search strategy. A search of fourteen pre-specified websites will be conducted for grey literature. Forward and backward citation checking of included studies will be conducted also. Studies will be included if they contain primary qualitative research and reference the experience of financial burden from the perspective of adult (≥ 18 years) community dwelling patients with multimorbidity. Studies from any country and in any language will be included. Titles and abstracts of search results will be screened; if a study appears relevant, then full-texts will be screened for eligibility. Study characteristics of included articles will be extracted. Study quality will be evaluated using the critical appraisal skills programme (CASP) checklist for qualitative research. These three processes will be carried out by two reviewers independently. Thematic-synthesis will be used to analyse data. This will be carried out by one reviewer and cross-checked by a second reviewer. The GRADE CERQual approach will be used to assess the overall confidence in the evidence. Discussion: This review will identify evidence on the experiences of financial burden for patients with multimorbidity and forms part of a project to support consideration of financial burden for patients in the development of clinical guidelines in Ireland. PROSPERO registration number: CRD42019135284
Contribuições da Tecnologia para Assistência de Enfermagem da Unidade de Terapia Intensiva
Authors: Siqueira Vinícius Rodrigues Barboza , Vasconcelos Wendyza Priscyla de Carvalho , Santos Gleidson Monteiro dos , Oliveira Gésica Kelly Da Silva 
Published: July 2019

O processo tecnológico foi inserido em nosso cotidiano em todos os aspectos, a cada dia são implementados em nossa rotina novas tendências com o intuito de contribuir para a otimização do tempo, diante disso houve o aprimoramento das práticas em saúde visando a evolução clínica positiva do paciente, oportunizando ao profissional a chance de agregar conhecimento e acompanhar as inovações no que concernem as “novas tecnologias” em prol das comunidades. Esta pesquisa objetivou investigar quais as contribuições da evolução tecnológica sobre a ótica dos enfermeiros dentro da Unidade de Terapia Intensiva (UTI), analisando as vantagens e desvantagens do uso da mesma na assistência ao paciente. Trata-se de um estudo transversal descritivo, de abordagem quantitativa, realizado com 14 enfermeiros do setor da UTI de um Hospital do interior de Pernambuco. Os resultados apontaram que a maioria dos equipamentos se encontrava em bom estado de conservação, além disso, os participantes pontuaram que o déficit do manuseio dos equipamentos, bem como a manutenção destes, se caracteriza como fatores que dificultam a assistência junto aos aparatos tecnológicos e equipamentos mais significativos dentro da Unidade de Terapia Intensiva. Os aparatos tecnológicos contribuem expressivamente para a melhoria da assistência à saúde, cabe a gestão condicionar fatores que propiciem o uso de equipamentos e aos profissionais que desenvolvem a assistência a capacidade e autonomia de utilizá-los de forma coerente.
Active Fault Zones of The 2006 Yogyakarta Earthquake Inferred from Tilt Derivative Analysis of Gravity Anomalies
Authors: Handayani Lina 
Published: July 2019

The 2006 Yogyakarta Earthquake had caused a disaster in Bantul area. Several institutions had reported different results for the epicenter location. However, aftershocks studies indicated that the rupture area was at about 10 km east of Opak Fault. Analysis of gravity anomaly, including several degrees of residual anomalies and tilt derivative, facilitated this regional tectonic study to determine the structural constraints on the main earthquake and its aftershocks. The Yogyakarta area was primarily characterized by several SW-NE faults; one of them is the Opak Fault. Among those faults,, there are a series of WNW-ESE faults. Several groups of these lineations indicated a presence of some pairs of parallel strike-slips faults that formed pull-a-part basins. The obtained structural pattern has signified the dynamic response of the force from the subduction of the Australian Plate toward Sunda (Eurasia) Plate. The subduction force produced the strike-slip fault in a parallel direction of subduction, and subsequently, the faults caused the formation of thrust structures that are perpendicular to them.Gempabumi Yogyakarta pada tahun 2006 telah menyebabkan bencana di daerah Bantul dan sekitarnya. Lokasi episenter yang ditentukan oleh beberapa lembaga menunjukkan hasil yang berbeda. Tetapi analisa gempabumi susulan telah menunjukkan daerah pegerakan hingga 10 km ke sebelah timur dari Sesar Opak. Analisa anomali gayaberat yang terdiri dari perhitungan anomali sisa dan turunan kemiringan (tilt derivative) diharapkan dapat membantu studi tektonik regional dalam menentukan batasan struktur yang menyebabkan kejadian gempabumi di daerah Yogyakarta. Daerah ini dicirikan oleh sesar-sesar berarah BD (Barat daya)-TL (Timur laut), yang salah satunya adalah Sesar Opak. Di antara sesar-sesar tersebut, terdapat pula deretan sesar-sesar berarah BBL (Barat barat laut)-TTG (Timur tenggara). Beberapa kelompok kelurusan-kelurusan membentuk kemungkinan adanya cekungan pull-a-part, yang terbentuk karena adanya deretan sesar-sesar strike-slip. Pola struktur yang diperoleh menunjukkan respon dinamik dari subduksi Lempeng Australia terhadap Lempeng Eurasia (Sunda). Tekanan dari gaya subduksi menyebabkan terbentuknya sesar-sesar strike-slip. Kemudian sesar-sesar tersebut menyebabkan adanya struktur sesar naik yang tegak lurus terhadapnya.
Microzonation of Soil Amplification Based on Microtremor, Spt and Cptu Data in Bandung Basin
Authors: Sari Anggun Mayang , Soebowo Eko , Fakhrurrozi Afnindar , Syahbana Arifan Jaya , Tohari Adrin 
Published: July 2019

Bandung Basin consists of Sunda-Tangkuban Perahu volcanic deposit that is made of lake sediment and an alluvial fan with fine to coarse-grained materials such as clay, silt and sand. The area is surrounded by several earthquake sources such as the Lembang, Cimandiri, and Baribis Faults. Therefore, it is important to understand soil dynamic problems with respect to seismic sources and soil properties. This research aims to investigate velocity amplification of the Bandung Basin using microtremor measurements and site classification based on the Standard Penetration Test (SPT) and Cone Penetrometer Test (CPTu). Velocity amplification was analyzed using the horizonal to vertical H/V spectral ratio, and site classification was determined using and values. Microzonation maps were developed using Geographical Information System (GIS) to determine the correlation between soil velocity amplification and site class. The results revealed that velocity amplification levels in the Bandung Basin vary with a range of 1.3 to 26.5. Site classification ranges from very dense soil and hard rock (class C), stiff soil (class D) to soft clay soil (class E). Site class E dominates the southeast part of the Bandung Basin with a high value of soil amplification. This scientific information is critical for further spatial planning focusing on infrastructure and residential building. Cekungan Bandung berasal dari endapan vulkanik Sunda-Tangkuban Perahu yang terdiri dari sedimen danau dan kipas aluvial dengan material berbutir halus hingga kasar seperti lempung, lanau, dan pasir. Daerah ini juga dikelilingi oleh beberapa sumber gempa yakni sesar Lembang, Cimandiri, dan Baribis. Oleh karena itu masalah dinamika tanah yang dipengaruhi oleh sumber seismik dan sifat tanah perlu menjadi perhatian. Tujuan penelitian ini adalah untuk mengetahui amplifikasi kecepatan tanah di wilayah cekungan Bandung dengan menggunakan alat mikrotremor dan metode site classification berdasarkan uji SPT dan CPTu. Amplifikasi kecepatan dianalisis menggunakan perbandingan rasio spektral H/V dan site classification yang diperoleh dengan menggunakan nilai dan . Peta mikrozonasi disusun menggunakan teknik Sistem Informasi Geografis (SIG) untuk menentukan korelasi amplifikasi tanah dan site class tanah. Hasil penelitian menunjukkan bahwa tingkat amplifikasi kecepatan di Cekungan Bandung bervariasi, berkisar 1,3 hingga 26,5. Site classification berkisar dari tanah yang sangat padat dan batuan keras (kelas C), tanah kaku (kelas D) hingga tanah lempung lunak (kelas E). Hasil penelitian menunjukkan site class E mendominasi bagian selatan Cekungan Bandung dengan nilai amplifikasi tanah yang tinggi. Informasi ilmiah ini diperlukan untuk perencanaan tata ruang kedepannya, dengan fokus pada infrastruktur dan bangunan tempat tinggal.