bluuebunny/crossref_metadata_2025_split huggingface dataset:
Divergent trends of open-surface water body area in the contiguous United States from 1984 to 2016
Authors: Zou Zhenhua , Xiao Xiangming , Dong Jinwei , Qin Yuanwei , Doughty Russell B. , Menarguez Michael A. , Zhang Geli , Wang Jie 
Published: March 2018

SignificanceStrong variations in open-surface water body areas have impacted United States agriculture, economy, society, and ecosystems. This study presents the uneven water-resource distribution across the contiguous United States with the western half of the United States having less water body area but stronger interannual variability compared with the eastern half. Divergent trends of open-surface water body area in the last three decades, mainly driven by climate, indicated that the water-poor regions of the Southwest and Northwest United States were getting poorer, while the water-rich regions of Southeast and far north Great Plains were getting richer. Surface water body shrinkage in drought years led to massive groundwater mining and the rapid decrease of land water storage in California and the southern Great Plains.
Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction
Authors: Lin Changfan , Top Deniz , Manahan Craig C. , Young Michael W. , Crane Brian R. 
Published: March 2018

Significance
This work resolves a long-standing controversy regarding the activation mechanism and photocycle of cryptochromes (CRYs), a broadly represented group of photosensors. We demonstrate a high degree of correspondence between the capability of the tryptophan (Trp) chain to photoreduce the flavin cofactor and biological activity. These results establish that the evolutionary pressure to conserve the Trp chain derives from maintaining a flavin photocycle that, in this case, entrains the fly circadian clock. Furthermore, we reengineer CRY to be more biologically photoresponsive by manipulating photoreduction by the Trp chain. As CRYs are important signaling molecules in animals, plants, and bacteria, and are increasingly used as optogenetic tools, the defined mechanism is relevant to many signaling processes and will enable novel applications.
Chloroplast SRP43 acts as a chaperone for glutamyl-tRNA reductase, the rate-limiting enzyme in tetrapyrrole biosynthesis
Authors: Wang Peng , Liang Fu-Cheng , Wittmann Daniel , Siegel Alex , Shan Shu-ou , Grimm Bernhard 
Published: March 2018

Significance
During the biogenesis of light-harvesting complexes, the posttranslational chloroplast signal recognition particle (cpSRP) pathway is highly coordinated with chlorophyll (Chl) biosynthesis. To ensure the required supply of newly synthesized Chl for the assembly of light-harvesting Chl a/b-binding proteins (LHCPs) while avoiding the accumulation of photoreactive tetrapyrrole intermediates, Chl synthesis is tightly regulated at the level of glutamyl-tRNA reductase (GluTR), the initial enzyme of rate-limiting 5-aminolevolinic acid (ALA) synthesis. Here, we found that the chaperone for LHCPs, the chloroplast SRP43, directly binds to and prevents aggregation of GluTR, thereby enhancing the stability of active GluTR. This finding reveals a posttranslational control of ALA synthesis, which helps plants to adjust their Chl synthesis rate in response to fluctuating environmental conditions.
Continuous plating/stripping behavior of solid-state lithium metal anode in a 3D ion-conductive framework
Authors: Yang Chunpeng , Zhang Lei , Liu Boyang , Xu Shaomao , Hamann Tanner , McOwen Dennis , Dai Jiaqi , Luo Wei , Gong Yunhui , Wachsman Eric D. , Hu Liangbing 
Published: March 2018

Significance
Solid-state lithium metal anode possesses great promise owing to its high energy density and improved safety. This work introduces a strategy for constructing a 3D Li metal anode, which is hosted in a solid-state ion-conducting host and shows a safe and dendrite-free plating/stripping behavior. The host is based on a garnet-type ion-conductive framework and a bottom-deposited Cu current collector. The Li anode is plated within the solid garnet framework from the bottom Cu layer and shows a dendrite-free deposition behavior, effectively averting the dendrite penetration issue. Owing to the 3D ion-conductive host, the volume change and interface contact problem of the Li anode have been significantly mitigated, realizing a high-capacity and safe Li metal anode for solid-state high-energy-density batteries.
Water-mediated conformational preselection mechanism in substrate binding cooperativity to protein kinase A
Authors: Setny Piotr , Wiśniewska Marta D. 
Published: March 2018

Significance
Cooperativity in substrate binding to a protein often involves some kind of interaction between distant binding sites mediated by the protein structure. Experimental studies indicate that the cooperative effect in protein kinase A relies on a shift in conformational equilibrium of the catalytic subunit, but its exact molecular basis remains unclear. Our molecular dynamics simulations provide atomistic insight into conformational states visited by the enzyme and its complexes and suggest a plausible mechanistic model contributing to cooperative substrate binding. Intriguingly, an important role seems to be played by water molecules that occupy two conserved hydration sites within the catalytic subunit.
Cooption of an appendage-patterning gene cassette in the head segmentation of arachnids
Authors: Setton Emily V. W. , Sharma Prashant P. 
Published: March 2018

SignificanceIn the fruit fly, ventral appendage (leg) identity is specified by a gene network includingWnt-1/wg,Sp6-9, andDll, but little is known about the conservation of this network beyond insects. We disrupted Wnt signaling andSp6-9in a spider, a member of Chelicerata, the sister group to all remaining arthropods. Our results provide support for the conservation of a leg development gene regulatory network across Arthropoda.Dllhas previously been reported to have a role in head segmentation that is restricted to spiders, and we show here that theSp6-9/Dllcassette has been independently coopted for arachnid head segmentation.
Reversal of orbital angular momentum arising from an extreme Doppler shift
Authors: Gibson Graham M. , Toninelli Ermes , Horsley Simon A. R. , Spalding Gabriel C. , Hendry Euan , Phillips David B. , Padgett Miles J. 
Published: March 2018

Significance
The emergence of “negative” frequencies in physical systems is often accompanied by intriguing consequences. For example, supersonic motion between a source and an observer leads to a negative Doppler-shifted frequency, the physical meaning of which is time reversal of the received signal. To our knowledge, the rotational analogue of this situation—the consequences of generating negative rotationally Doppler-shifted waves—has not been studied. Here we show, using an acoustic source, that a negative rotational Doppler shift is associated with a handedness reversal of the orbital angular momentum carried by the wave. We demonstrate that this handedness reversal can occur even at significantly subsonic velocities, making our findings relevant to interactions of ultrafast rotating systems with optical frequency radiation.
Cross-linking of Orai1 channels by STIM proteins
Authors: Zhou Yandong , Nwokonko Robert M. , Cai Xiangyu , Loktionova Natalia A. , Abdulqadir Raz , Xin Ping , Niemeyer Barbara A. , Wang Youjun , Trebak Mohamed , Gill Donald L. 
Published: March 2018

Significance
The work presents a unique understanding of the organization and function of two ubiquitously expressed proteins, central in generating calcium signals in all cell types. These are the intracellular calcium sensing “STIM” proteins, and the highly selective cell surface “Orai” calcium channels. We reveal that STIM proteins can cross-link Orai channels, resulting in a reorganized microenvironment within the membrane junctions in which they function, with important consequences in the generation of oscillatory calcium signals. Interestingly, we show a variant STIM protein widely expressed in cells functions to prevent the STIM–Orai cross-linking and clustering of channels. This provides important modulation of calcium signal generation and can serve to protect cells from overstimulation of the calcium signaling machinery.
Recombinant immunotoxins with albumin-binding domains have long half-lives and high antitumor activity
Authors: Wei Junxia , Bera Tapan K. , Liu Xiu Fen , Zhou Qi , Onda Masanori , Ho Mitchell , Tai Chin-Hsien , Pastan Ira 
Published: March 2018

Significance
Recombinant immunotoxins are anticancer agents consisting of Fv of an antibody that targets a cancer cell and a protein toxin that kills the cell. Despite its short half-life in the circulation, Moxetumomab pasudotox is a recombinant immunotoxin that has produced many complete regressions in patients with leukemia, because the leukemia cells are readily accessible to the agent. Immunotoxins targeting solid tumors are less active, because it takes many hours to enter bulky tumors and by then the blood levels have fallen to ineffective levels. To overcome this deficiency, we have designed and produced a generation of immunotoxins containing albumin-binding domains that dramatically increase their half-life in the circulation and antitumor activity in mice.
Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling
Authors: Staus Dean P. , Wingler Laura M. , Choi Minjung , Pani Biswaranjan , Manglik Aashish , Kruse Andrew C. , Lefkowitz Robert J. 
Published: March 2018

Significance
β-Arrestin regulates G protein-coupled receptor (GPCR) signaling by interacting with two regions of agonist-activated receptors—the phosphorylated C terminus and the seven transmembrane helix bundle. The phosphorylation pattern on GPCRs is thought to be the primary driver of β-arrestin binding affinity and functional consequences. To more effectively delineate the relative contributions of these two interactions, we present an innovative strategy to homogeneously phosphorylate purified GPCRs—enzymatic ligation of a synthetic phosphopeptide. This approach unexpectedly revealed that different receptors with identical phosphorylation patterns exhibit dramatic variability in their ability to couple to β-arrestin through the transmembrane core. These differences could play an important role in tuning the balance of G protein- and β-arrestin–mediated cellular signaling pathways stimulated by each GPCR.
Internal states and extrinsic factors both determine monkey vocal production
Authors: Liao Diana A. , Zhang Yisi S. , Cai Lili X. , Ghazanfar Asif A. 
Published: March 2018

Significance
Understanding how human speech evolved requires investigating how our closest extant relatives—nonhuman primates—use and produce their vocalizations. However, some believe that primate vocalizations are driven purely by internal states such as arousal and thus have little or no relationship with human speech. We show that, in marmoset monkeys, vocal production varies systematically as a function of social distance and—via measures of heart rate—with arousal levels. However, arousal is not inextricably linked with primate vocal production. Rather, it interacts in complex ways with external cues, revealing the interplay between communication and energetic demands.
BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease
Authors: Bao Jian , Qin Min , Mahaman Yacoubou Abdoul Razak , Zhang Bin , Huang Fang , Zeng Kuan , Xia Yiyuan , Ke Dan , Wang Qun , Liu Rong , Wang Jian-Zhi , Ye Keqiang , Wang Xiaochuan 
Published: March 2018

SignificanceBACE1 is a rate-limiting enzyme for amyloid beta polypeptide production, which plays a crucial role in Alzheimer’s disease (AD) pathogenesis. However, how this essential protease is posttranslationally regulated remains incompletely understood. In the current study, we show that K501 residue on BACE1, a ubiquitin modification site, is also competitively SUMOylated. We discovered that SUMOylation of BACE1 augments its stability and enzymatic activity, resulting in senile plaque formation and cognitive defect. Identification of the posttranslational modification on BACE1 provides insight into the molecular mechanism in AD.
LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes
Authors: Sheng Nengyin , Bemben Michael A. , Díaz-Alonso Javier , Tao Wucheng , Shi Yun Stone , Nicoll Roger A. 
Published: March 2018

Significance
Long-term potentiation (LTP) is the most compelling cellular and molecular model for learning and memory. Both AMPARs and KARs, two separate classes of glutamate receptor with very limited homology, express normal LTP in pyramidal neurons. However, the general underlying molecular mechanism remains a mystery. Here, with the strategy of single-cell molecular replacement we show that the PDZ-binding domains of AMPAR/TARP and KAR/Neto receptor complexes are essential for basal synaptic transmission and LTP. Our work suggests that the glutamate receptors share the same postsynaptic requirement for LTP.
Debussy's Speculative Idea: Orchestration and the Substance of Jeux
Authors: Clarke Simon 
Published: March 2018

ABSTRACTThis article seeks to determine the extent to which timbral and textural concerns inform the musical substance of Debussy's Jeux. Of particular interest are passages in which foreground detail effaces itself in the interests of orchestral qualities, those where an overabundance of surface detail is preconfigured so as to maximize orchestral efficacy, and sections where a more traditional distinction between compositional content and orchestrational attributes seems to obtain. It is Hegelian substance ultimately that I have in mind, however, on which basis I seek to distinguish between unification and synthesis – I argue that Jeux's immediacy is overcome through negating (orchestrational) activity, arriving thus at the objectively real (realized and posited) product. On this basis, Jeux's substance, including its orchestral aspects, is best understood speculatively.
Constraining the mass of dark photons and axion-like particles through black-hole superradiance
Authors: Cardoso Vitor , Dias Óscar J.C. , Hartnett Gavin S. , Middleton Matthew , Pani Paolo , Santos Jorge E. 
Published: March 2018

Ultralight bosons and axion-like particles appear naturally in different scenarios and could solve some long-standing puzzles. Their detection is challenging, and all direct methods hinge on unknown couplings to the Standard Model of particle physics. However, the universal coupling to gravity provides model-independent signatures for these fields. We explore here the superradiant instability of spinning black holes triggered in the presence of such fields. The instability taps angular momentum from and limits the maximum spin of astrophysical black holes. We compute, for the first time, the spectrum of the most unstable modes of a massive vector (Proca) field for generic black-hole spin and Proca mass. The observed stability of the inner disk of stellar-mass black holes can be used to derivedirectconstraints on the mass of dark photons in the mass range 10−13 eV≲ mV ≲ 3× 10−12 eV. By including also higher azimuthal modes, similar constraints apply to axion-like particles in the mass range 6×10−13 eV≲ mALP ≲ 10−11 eV. Likewise, mass and spin distributions of supermassive BHs—as measured through continuum fitting, Kα iron line, or with the future space-based gravitational-wave detector LISA – imply indirect bounds in the mass range approximately 10−19 eV≲ mV, mALP ≲ 10−13 eV, for both axion-like particles and dark photons. Overall, superradiance allows to explore a region of approximately 8 orders of magnitude in the mass of ultralight bosons.
Developer-led gentrification and legacies of urban policy failure in Post-Riot Tottenham
Authors: Dillon Denis , Fanning Bryan 
Published: March 2018

AbstractThis article is a sequel to an analysis of diagnoses of the causes of the 2011 Tottenham Riots published in this journal (2012) which charts the emergence of a predominant focus on developer-led gentrification in the area. We locate this focus on gentrification within United Kingdom urban policy and political debates and through a historical analysis of regeneration policy and community development as this played out in Northumberland Park, the most deprived area of Tottenham.
Demographic-Specific Rates for Life Events in the Cardiovascular Health Study and Comparisons With Other Studies
Authors: Vitaliano Peter P , Fitzpatrick Annette L , Williams Lee E , Montano Michalina A , Russo Joan E 
Published: March 2018

AbstractPurpose of the Study(1a) We use the Cardiovascular Health Study (CHS), a multi-site heterogeneous sample of Medicare enrollees (N = 5,849) to provide rates for specific life events experienced within 6 months; (1b) We present rates for 29 other studies of community-residing older adults (N = 41,308); (2) For the CHS, we provide demographic-specific rates and predicted probabilities for age [young-old (65–75) vs old-old (≥75)], gender, race, marital status, and education.Design/MethodsThe CHS sample is 57.6% women, 84.2% white (15.8% black), and 66.3% married. Mean age is 72.8 years (standard deviation [SD] = 5.6, range = 65–100) and education is 13.7 years (SD = 4.8). Life events were interviewer-assessed. Regressions estimated associations of life event rates with demographic groups (e.g., age), controlling for other demographic variables (e.g., gender, etc.).Results(1a) CHS rates ranged from 44.7% (death of someone close) to 1.1% (retirement/work changes). (1b) Most life event studies used total scores and only 5 that met our inclusion criteria used time intervals &lt;1 year; longer intervals were associated with higher rates. (2) In the CHS, the life event for illnesses was related to 5 demographic variables (net the other 4 demographic variables), difficulties caregiving to 4, and worse relationships to 3 demographic variables. Race was related to 8 life events, marital status to 7, education to 6, and age to 4 events.ImplicationsBy identifying demographic groups at highest risk for life events, this research focuses on older adults at greatest risk for health problems. These data are necessary for translating research into interventions, practice, and policy.
Preoperative Vs Postoperative Radiosurgery For Resected Brain Metastases: A Review
Authors: Prabhu Roshan S , Patel Kirtesh R , Press Robert H , Soltys Scott G , Brown Paul D , Mehta Minesh P , Asher Anthony L , Burri Stuart H 
Published: March 2018

Abstract
Patients who undergo surgical resection of brain metastases are at significant risk of cavity local recurrence without additional radiation therapy. Postoperative stereotactic radiosurgery (SRS) is a method of focal treatment to the cavity to maximize local control while minimizing the risk of neurocognitive detriment associated with whole brain radiation therapy. Recently published randomized trials have demonstrated the benefit of postoperative SRS in terms of cavity tumor control and preserving neurocognition. However, there are several potential drawbacks with postoperative SRS including a possible increase in symptomatic radiation necrosis because of the need for cavity margin expansion due to target delineation uncertainty, the variable postoperative clinical course and potential delay in administering postoperative SRS, and the theoretical risk of tumor spillage into cerebrospinal fluid at the time of surgery. Preoperative SRS is an alternative paradigm wherein SRS is delivered prior to surgical resection, which may effectively address some of these potential drawbacks. The goal of this review is to examine the rationale, technique, outcomes, evidence, and future directions for the use of SRS as an adjunct to surgical resection. This can be delivered as either preoperative or postoperative SRS with potential advantages and disadvantages to both approaches that will be discussed.
The Criminal Histories of Drug-Drive Offenders
Authors: Nunn James 
Published: March 2018

Abstract
This study examined the previous criminal behaviour of individuals who were arrested for violating the drug driving over the prescribed limit offence, introduced into the UK in March 2015. The sample consists of individuals arrested during the first year of enforcement of this offence from March 2015 to March 2016 within the jurisdictional boundaries of the Metropolitan Police Service in London. The previous criminal behaviour of the research subjects was framed within a number of criminological theories and there is examination of any correlation between their criminal history and the drug-driving offence they had been arrested for. The criminal activity was obtained from each individual’s criminal record held on the police national computer and coded with regards to offence groups. As well as criminal sanctions, there was also an examination of drug-related arrest histories. The results indicate a high level of previous criminal activity with drugs and driving matters dominating that activity. This supports the construct that, in this context, drug driving fits within their patterns of offending.
Challenges and solutions for studying collective animal behaviour in the wild
Authors: Hughey Lacey F. , Hein Andrew M. , Strandburg-Peshkin Ariana , Jensen Frants H. 
Published: March 2018

Mobile animal groups provide some of the most compelling examples of self-organization in the natural world. While field observations of songbird flocks wheeling in the sky or anchovy schools fleeing from predators have inspired considerable interest in the mechanics of collective motion, the challenge of simultaneously monitoring multiple animals in the field has historically limited our capacity to study collective behaviour of wild animal groups with precision. However, recent technological advancements now present exciting opportunities to overcome many of these limitations. Here we review existing methods used to collect data on the movements and interactions of multiple animals in a natural setting. We then survey emerging technologies that are poised to revolutionize the study of collective animal behaviour by extending the spatial and temporal scales of inquiry, increasing data volume and quality, and expediting the post-processing of raw data.
This article is part of the theme issue ‘Collective movement ecology’.