bluuebunny/crossref_metadata_2025_split huggingface dataset:
Movement Improves the Quality of Temporal Perception and Decision-Making
Authors: Wiener Martin , Zhou Weiwei , Bader Farah , Joiner Wilsaan M. 
Published: August 2019

AbstractA critical aspect of behavior is that mobile organisms must be able to precisely determine where and when to move. A better understanding of the mechanisms underlying precise movement timing and action planning is therefore crucial to understanding how we interact with the world around us. Recent evidence suggests that our experience of time is directly and intrinsically computed within the motor system, consistent with the theory of embodied cognition. To investigate the role of the motor system, we tested human subjects (n= 40) on a novel task combining reaching and time estimation. In this task, subjects were required to move a robotic manipulandum to one of two physical locations to categorize a concurrently timed suprasecond. Critically, subjects were divided into two groups: one in which movement during the interval was unrestricted and one in which they were restricted from moving until the stimulus interval had elapsed. Our results revealed a higher degree of precision for subjects in the free-moving group. A further experiment (n= 14) verified that these findings were not due to proximity to the target, counting strategies, bias, or movement length. A final experiment (n= 10) replicated these findings using a within-subjects design, performing a time reproduction task, in which movement during encoding of the interval led to more precise performance. Our findings suggest that time estimation may be instantiated within the motor system as an ongoing readout of timing judgment and confidence.
Positive correlation between psoriasis vulgaris severity degree with HbA1C level
Authors: Adiguna Made Swastika , Wardhana Made , Rahardjo Fresa Nathania 
Published: August 2019

Introduction: Psoriasis is a skin abnormality based on chronic inflammation immune mediated. Inflammatory mediator roles (Th-1, TNF-α, IL-6,IL-7, IL-8, IL-17, and IL-23) in its pathogenesis proven to inhibit insulin receptor and glucose uptake from fat tissue and causing insulin resistance, then blood glucose level increased. Mean blood glucose level within 3 months can be represented by HbA1c (glycosylated haemoglobin) level. HbA1c is a bond between glucose and hemoglobin. Objective: The aim of this study is to understanding correlation between psoriasis vulgaris severity degree with HbA1c.Material and methods: This study is using cross sectional method. HbA1c level examination done by drawing venous blood, then analyzed with chromatography method. Samples were selected by using inclusion and exclusion criteria and consecutive sampling method.Result: Study result shows subject consist of total 51 subjects consists of 33 subjects with psoriasis vulgaris (22 males and 11 females with youngest age of 15 and oldest age of 65 years old), and 18 subjects without psoriasis vulgaris. Psoriasis vulgaris severity degree measured with Psoriasis Area Severity Index (PASI), then grouped to 3 categories: mild PASI score <6, moderate PASI score 6 – 12, and severe PASI score> 12. Mostly (15 subjects) including mild category. HbA1c level on this study subjects resulted minimum level of 4.6%, maximum 12.1 %, and median 5.4%. Based on Perkeni consensus, normal HbA1c level is <5,7%, prediabetes 5,7-6,4%, and diabetes >6,5%. HbA1c level of psoriasis vulgaris subjects are higher than non psoriasis vulgaris subjects significantly (p=0,019). Psoriasis vulgaris causing increase of HbA1c level with Prevalence Ratio (PR) 6,55. Thus, Psoriasis vulgaris subjects have increased risk 6,5 times to increase HbA1c level compared with non psoriasis vulgaris subjects. Correlation between severity degree and HbA1c level found in positive course significantly with moderate strength of correlation (Spearman correlation; r = 0.580, p<0,001).Conclusion: HbA1c level on psoriasis vulgaris subjects are higher than non psoriasis vulgaris, and psoriasis vulgaris severity degree positively correlated with HbA1c increasing level. Every increase of psoriasis vulgaris severity degree will cause increase level of HbA1c.
17 VE 19 YAŞ ALTI KADIN MİLLİ BADMİNTON OYUNCULARININ MÜSABAKA SIRASINDA YAPTIKLARI BASİT HATALARIN KARŞILAŞTIRILMASI
Authors: ÖZGÜR Beyhan 
Published: August 2019

Bu çalışmada 17 ve 19 yaş grubu kadın
milli badminton oyuncularının maç ortamında yaptıkları basit hataların
karşılaştırılması amaçlanmıştır.Araştırmaya, U19 kategorisinden 6 (yaş 17,17±0,40)
ve U17 kategorisinden 15 (yaş 15,53±0,51) kadın milli badmintoncu gönüllü
olarak katılmıştır. Basit hata analizi için U19 kategorisinde 9 tek kadın maçı
ve U17 kategorisinde 20 tek kadın maçı değerlendirilmiştir. Basit hatalar, TH (toplamda
yapılan basit hata), KTS (kaybedilen toplam sayı), BKTSY (basit hataların
kaybedilen toplam sayıdaki yüzdesi), HÖK (hata ön kort), HOK (hata orta kort),
HAK (hata arka kort), HAÖK (hata aut ön kort), HAOK (hata aut orta kort), HAAK
(hata aut arka kort), TAH (toplam aut hatası), HFÖK (hata file ön kort), HFOK
(hata file orta kort), HFAK (hata file arka kort), TFH (Toplam File Hatası)
olarak değerlendirilmiştir. Elde edilen veriler SPSS 22 paket programına aktarılmış ve
tanımlayıcı istatistikleri için minimum, maksimum, ortalama ve standart sapma
değerlerihesaplanmıştır. Kategoriler arası
ve kazanan-kazanamayan sporcular arası farkın analizi için Mann
Whitney U testi kullanılmıştır. Sonuç olarak,
U19 kategorisinde kazanan ve kazanamayan sporcuların KTS değerleri arasında
anlamlı fark bulunurken (p&lt;0,05), U17 kategorisinde kazanan ve kazanamayan
sporcuların KTS(p&lt;0,01), TH, TFH ve HOK değerleri
arasında anlamlı fark bulunmuştur (p&lt;0,05).
Cechy pracy a zadowolenie z pracy
Authors: Hauk Mateusz 
Published: August 2019

Celem badań własnych była analiza relacji pomiędzy cechami pracy a zadowoleniem z pracy. Punktem wyjścia do analizy powyższego problemu była Koncepcja Właściwości Pracy Hackmana i Oldhama (1980), a także liczne badania weryfikacyjne, wskazujące na potrzebę rozpatrywania cech pracy w trzech grupach, odpowiednio: motywacyjnych, społecznych i kontekstowych. W badaniach wzięło udział 375 osób, w wieku od 19 do 64 lat, reprezentujących zawody zróżnicowane branżowo.
Otrzymane wyniki wskazały, iż najsilniejszy związek z zadowoleniem pracowników mają tzw. cechy społeczne. Jednocześnie procent wariancji zadowolenia z pracy wyjaśniany przez cechy pracy okazał się znikomy, co wskazuje na potrzebę dalszej eksploracji czynników związanych z zadowoleniem z pracy, przy uwzględnieniu bardziej zaawansowanych modeli i większego zestawu zmiennych.
PROCAMPO: FIELD EDUCATION POLICY
Authors: Santos Marilene , Fetzner Andréa Rosana 
Published: August 2019

PROCAMPO: FIELD EDUCATION POLICY Abstract: The article integrates researches that focus on the analysis of the Field Education policy as an alternative to improve the quality of education and contribute to the development of rural areas, it also discusses the Field Education as public policy and its implementation through specific programs. The empirical material analyzed is the Programme of Support to Field Higher Education Degree ‘Procampo/Pronacampo’. The analysis focuses in reflecting on the history and definition of concepts in the discussion of Field Education by social movements forefront State bodies represented by the Ministry of Education. In addition, it also discusses Procampo as a significant action of implementation and expansion of Field Education as part of teacher training. The conclusions highlight advances in this implementation; it considers Procampo as an innovation in teacher training, however, to ensure the public policy challenges ahead and a long way by conflicts and clashes of intermingled divergent interests.Key words: Field Education - Public Policy - Procampo
Pengaruh Dwelling Time pada Penerimaan Pajak Impor di Indonesia
Authors: Hilal Adam Syaiful , Lisna Vera 
Published: August 2019

High dwelling time in Indonesia has been in the spotlight of President since his visit to the Port of Tanjung Priok in 2014. This could bring impact on international trade, one of which is indicated by import tax revenue. The value of import in Indonesia which continues to fall has brought impact to lower country revenue from import tax. The objective of this study is to analyze the effect of dwelling time on import tax revenue in Indonesia. The results from recursive equation system of Error Correction Model (ECM) by using data during January 2014 to November 2016 show that lower dwelling time will increase import tax revenue in Indonesia. ------------------------------------ Lamanya dwelling time menjadi sorotan Presiden RI sejak kunjungannya ke Pelabuhan Tanjung Priok tahun 2014 silam. Hal ini dapat berdampak pada perdagangan internasional, salah satunya diukur dari penerimaan pajak impor. Nilai impor Indonesia yang terus turun berdampak pada rendahnya penerimaan negara dari pajak impor. Penelitian ini bertujuan menganalisis pengaruh dwelling time pada penerimaan pajak impor di Indonesia. Berdasarkan hasil estimasi sistem persamaan rekursif Error Correction Model (ECM) dengan data periode Januari 2014–November 2016 diketahui bahwa dwelling time yang lebih rendah akan meningkatkan penerimaan pajak impor di Indonesia.
Desain Lingkungan Belajar yang Menyenangkan Berbasis Flipped Classroom di Sekolah Dasar
Authors: Rindaningsih Ida , Hastuti Wiwik Dwi , Findawati Yulian 
Published: August 2019

Kemajuan teknologi abad 21 menuntut pendidik untuk segera beradaptasi dengan kemajuan teknologi digital. Dibutuhkan model pembelajaran yang sesuai dengan percepatan kemajuan teknologi dan menghubungkan pembelajaran didalam dan diluar kelas. Flipped Classroom melibatkan pergeseran energi dari instruktur menuju keaktifan siswa dengan memanfaatkan teknologi untuk meningkatkan lingkungan belajar. Tujuan dari penelitian ini adalah untuk merancang desain lingkungan belajar berbasis Flipped classroom. Desain ini memberikan gambaran alur pembelajaran yang sistematis berdasarkan pada kajian flipped classroom dan lingkungan belajar yang telah dibangun oleh peneliti sebelumnya. Penelitian ini merupakan literature review dan telah melalui proses perancangan dan validasi para ahli. Hasil penelitian menunjukkan bahwa desain lingkungan belajar berbasis flipped classroom terbukti layak, valid, dan praktis untuk diterapkan di sekolah.
Spatio-temporal transcriptome construction of early mouse embryo with Geo-seq and Auto-seq
Authors: Guizhong Cui , Chen Jun , Chen Shirui , Qian Yun , Peng Guangdun , Jing Naihe 
Published: August 2019

Abstract
The regionalization of cell fates heralding the formation of the basic body plan is conserved in vertebrate embryos, the mechanisms of which is instrumental for understanding embryonic programming and stem cell-based translational study. However, a comprehensive genome-wide molecular annotation of the mechanism that determines the lineage specification and cell fate decision has not been clarified. Here, we combined laser microdissection-based spatial transcriptome analysis (Geo-seq) and automated platform-based low-input RNA sequencing (Auto-seq), and generated a series of spatial transcriptome dataset that encompass mouse embryos from pre-gastrulation (E5.5) to late gastrulation (E7.5) on all germ layers in the embryo proper.
MiR-190a Potentially Ameliorates Postoperative Cognitive Dysfunction by Regulating Tiam1
Authors: Liu Qiang , Hou Aisheng , Zhang Yongyi , Guo Ying , Li Jingjing , Yao Yinghao , Niu Kaimeng , Li Hao , Ma Yunlong , Cao Jiangbei 
Published: August 2019

Abstract
Postoperative cognitive dysfunction (POCD) affects a large number of post-surgery patients, especially for the elderly. However, the etiology of this neurocognitive disorder is largely unknown. Even if several studies have reported a small number of miRNAs as the essential modulatory factors in POCD, these findings are still rather limited. In this study, we used two miRNA microarray datasets to perform differential expression analyses of miRNAs in the hippocampus of POCD model mice. We found that nine miRNAs showed significant associations with POCD in both datasets. Among these miRNAs, mmu-miR-190a-3p was the most significant one. By performing weighted gene co-expression network analysis, we found 25 co-expression modules, of which mmu-miR-190a-3p was significantly anti-correlated with the red module. Moreover, in this red module, 314 genes were significantly enriched in four pathways such as axon guidance and calcium signaling pathway, which are well-documented to be associated with psychiatric disorders and brain development. Also, 169 of the 314 genes were highly correlated with mmu-miR-190a-3p, and four genes (Sphkap, Arhgef25, Tiam1, and Ntrk3) had putative binding sites at 3'-UTR of mmu-miR-190a-3p. Based on protein-protein network analysis, we detected that Tiam1 was a central gene regulated by the mmu-miR-190a-3p. Taken together, we conclude that mmu-miR-190a-3p is involved in the etiology of POCD and may serve as a novel predictive indicator for POCD.
TReatIng Urinary symptoms in Men in Primary Healthcare using non-pharmacological and non-surgical interventions (TRIUMPH) compared with usual care: study protocol for a cluster randomised controlled trial
Authors: Frost Jessica , Lane J Athene , Cotterill Nikki , Fader Mandy , Hackshaw-McGeagh Lucy , Hashim Hashim , Macaulay Margaret , MacNeill Stephanie J , Noble Sian , Rees Jonathan , Ridd Matthew J , Robles Luke , Taylor Gordon , Taylor Jodi , Drake Marcus , Worthington Jo 
Published: August 2019

Abstract
Background

Lower urinary tract symptoms (LUTS) can relate to urinary storage or voiding. In men, the prevalence and severity of LUTS increases with age, with a significant impact on quality of life. The majority of men presenting with LUTS are managed by their General Practitioner (GP) in the first instance, with conservative therapies recommended as initial treatment. However, the provision of conservative therapies in primary care is variable and can be time and resource limited. GPs require practical resources to enhance patient engagement with such interventions. TRIUMPH aims to determine whether a standardised and manualised care intervention delivered in primary care achieves superior symptomatic outcome for LUTS versus usual care.

Methods

TRIUMPH is a 2-arm cluster randomised controlled trial (RCT) being conducted in 30 National Health Service (NHS) General Practices in England. The TRIUMPH intervention comprises a standardised LUTS advice booklet developed for the trial with patient and health care professional (HCP) consultation. The booklet is delivered to patients by nurses/healthcare assistants following assessment of their urinary symptoms. Patients are directed to relevant sections of the booklet, providing the manualised element of the intervention. To encourage adherence, HCPs provide follow-up contacts over 12 weeks. Practices are randomised 1:1 to either deliver the TRIUMPH intervention or a usual care pathway. The patient-reported International Prostate Symptom Score (IPSS) at 12 months post-consent is the primary outcome. Secondary outcomes include cost-effectiveness, patient reported outcomes on LUTS, quality of life, and patient and HCP acceptability and experience of the intervention. Primary analyses will be conducted on an intention-to-treat basis.

Discussion

It is unclear whether conservative therapies for male LUTS are effectively delivered in primary care using current approaches. This can lead to men being inappropriately referred to secondary care or experiencing persistent symptoms. Primary care therefore holds the key to effective treatment for these men. The TRIUMPH intervention, through its standardised and manualised approach, has been developed to support GP practices in delivering effective conservative care. This pragmatic cluster RCT will provide robust evidence in a primary care setting to inform future guidelines.
Shortening Antibiotic Duration in the Treatment of Acute Cholangitis. Rationale and Study Protocol for an Open Label Randomized Controlled Trial.
Authors: Iwata Kentaro , Doi Asako , Oba Yuichiro , Matsuo Hiroo , Ebisawa Kei , Nagata Manabu , Nishimura Sho , Yoshimura Kenichi , Masuda Atsuhiro , Shiomi Hideyuki , Kodama Yuzo 
Published: August 2019

Abstract
Background: Antimicrobial therapy with appropriate biliary drainage is considered the standard of care of acute cholangitis, but the optimal duration of antimicrobial therapy remains unknown. Seven to 10 days of antimicrobial therapy is common for the treatment of acute cholangitis, but recent retrospective cohort study suggested shorter duration might be effective enough. Shorter duration of antimicrobial therapy can be beneficial in decreasing the length of hospital stay, improving patients’ quality of life, decreasing adverse effects, and even contributing to decrease in the occurrence of antimicrobial resistance. Methods/design: We will conduct a multi-center, open-label, randomized, non-inferiority trial to compare short course therapy (SCT) with conventional long course therapy (LCT) in treating patients with acute cholangitis. SCT consists of 5-day intravenous antimicrobial therapy if the patients had clinical improvement, while at least 7 days of intravenous antibiotics will be provided to LCT group. The primary outcome is clinical cure at 30 days after their onset. Patients will be randomly assigned with open label fashion. A total sample size of 150 was estimated to provide a power of 80% with a one-sided alpha level of 2.5% and a non-inferiority margin of 10%. Discussion: This trial is expected to reveal whether SCT is non-inferior to conventional LCT or not, and may provide evidence that one can able to shorten the treatment duration for acute cholangitis for the benefit of the patients.
CRISPR elements provide a new framework for the genealogy of the citrus canker pathogen Xanthomonas citri pv. citri
Authors: Jeong Kwanho , Muñoz-Bodnar Alejandra , Rojas Nathalia Arias , Poulin Lucie , Rodriguez-R Luis Miguel , Gagnevin Lionel , Vernière Christian , Pruvost Olivier , Koebnik Ralf 
Published: August 2019

Abstract
Background
Xanthomonads are an important clade of Gram-negative bacteria infecting a plethora of economically important host plants, including citrus. Knowledge about the pathogen’s diversity and population structure are prerequisite for epidemiological surveillance and efficient disease management. Rapidly evolving genetic loci, such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), are of special interest to develop new molecular typing tools.

Results
We analyzed CRISPR loci of 56 Xanthomonas citri pv. citri strains of world-wide origin, a regulated pathogen causing Asiatic citrus canker in several regions of the world. With one exception, 23 unique sequences built up the repertoire of spacers, suggesting that this set of strains originated from a common ancestor that already harbored these 23 spacers. One isolate originating from Pakistan contained a string of 14 additional, probably more recently acquired spacers indicating that this genetic lineage has or had until recently the capacity to acquire new spacers. Comparison of CRISPR arrays with previously obtained molecular typing data, such as amplified fragment length polymorphisms (AFLP), variable-number of tandem-repeats (VNTR) and genome-wide single-nucleotide polymorphisms (SNP), demonstrated that these methods reveal similar evolutionary trajectories. Notably, genome analyses allowed to generate a model for CRISPR array evolution in X. citri pv. citri, which provides a new framework for the genealogy of the citrus canker pathogen.

Conclusions
CRISPR-based typing will further improve the accuracy of the genetic identification of X. citri pv. citri outbreak strains in molecular epidemiology analyses, especially when used concomitantly with another genotyping method.
Simulating Soybean Yield Potential under Optimum Management
Authors: Purcell Larry C. , Van Roekel Ryan J. 
Published: August 2019

Core Ideas
Soybean yield and crop growth was measured in high‐yield contest fields.
Radiation use efficiency and nitrogen uptake were greater than recorded values.
Yield was grossly under‐predicted using default growth parameters.
Yield predictions were greatly improved using measured growth parameters.
Crop models have played important roles in identifying potential constraints for crop growth and yield. A relatively simple soybean [Glycine max (L.) Merr.] model consisting of a daily C, N, and water budget was used to simulate yields for optimum production environments at Fayetteville, AR, and at a farmer's contest field in Missouri for 2012 to 2013. Data were collected on radiation use efficiency (RUE), N accumulation rate, specific leaf nitrogen (SLN), and the dry matter accumulation coefficient (DMAC) as a measure of whole‐crop seed growth rate. In Fayetteville, measured yields ranged from 4977 to 7144 kg ha−1, and simulated yields averaged 34.0% below the measured yields using the default model parameters. Using measured parameters in a modified model, predicted yields were 2.8% above observed. Default parameter simulations for the contest fields were 39.0% below measured yield and were 18.7% below measured yield when using measured parameters. Sensitivity analyses indicated that lower DMAC values increased yields due to slower seedfill rates, allowing additional N accumulation and a slower translocation of N to the growing seeds. Simulating an increased SLN and RUE increased predicted yields in 2012 and 2013 when N accumulation rates were great enough to supply the required N for new biomass. Alternatively, increasing N accumulation rates increased yield up to a plateau when all N requirements were met. These results illustrate the importance and interconnectivity of the crop growth processes relating to C and N metabolism and that current bounds for crop growth characteristics should be reconsidered.
Estimating Herd‐Scale Methane Emissions from Cattle in a Feedlot Using Eddy Covariance Measurements and the Carbon Dioxide Tracer Method
Authors: Prajapati Prajaya , Santos Eduardo A. 
Published: August 2019

Measurements of methane (CH4) emissions from ruminants could provide invaluable data to reduce uncertainties in the global CH4 budget and to evaluate mitigation strategies to lower greenhouse gas emissions. The main objective of this study was to evaluate a new CO2 tracer (CO2T) approach that combined CH4 and CO2 atmospheric concentrations with eddy covariance (EC) CO2 flux measurements to estimate CH4 emissions from cattle in a feedlot. A closed‐path EC system was used to measure CH4 and CO2 fluxes from a feedlot in Kansas. The EC flux measurements were scaled from landscape to animal scale using footprint analyses. Emissions of CH4 from the cattle were also estimated using the CO2T approach and measured CO2 and CH4 concentration, and scaled EC CO2 fluxes. The CH4 and CO2 concentration ratios showed a distinct diel trend with greater values during the daytime. Average monthly CH4 emission estimates using the CO2T approach ranged from 72 to 127 g animal−1 d−1, which was consistent with the values reported in other studies that had similar animal characteristics. The CO2T method CH4 emission estimates showed good agreement with scaled CH4 EC fluxes (slope = 0.9 and R2 = 0.8) for cold and dry months. However, the agreement between the two techniques was significantly reduced (slope = 1.5 and R2 = 0.6) during wet and warm months. On average, the CO2T method CH4 emission estimates were 3% greater than the EC CH4 emissions. Overall, our results suggest that the CO2T method can be used to estimate enteric feedlot CH4 emissions.Core Ideas
The CO2 tracer method (CO2T) was used to estimate enteric CH4 emissions in a feedlot.
The CO2T method estimates were in good agreement with eddy covariance (EC) measurements.
The agreement between CO2T and EC method was reduced during the wet and warm months.