bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammation and Ovarian Function in Reproductive‐Aged Women
Authors: Long Anneliese , Steiner Anne Z. , Thompson Amanda L. , Jahnke Hannah R. , Harris Benjamin S. , Jukic Anne Marie 
Published: December 2024

ABSTRACTIntroductionInflammation is a marker of immune activation. Inflammation may have an effect on both ovarian function and luteal function, both essential to pregnancy. High inflammation may also signal dysregulated processes within the ovary, which could be in part measured through Anti‐Müllerian hormone, follicle‐stimulating hormone, and inhibin B levels.ObjectiveTo determine the relationship between inflammation, measured by C‐reactive protein, and three biomarkers of ovarian function during the early follicular phase: Anti‐Müllerian hormone, follicle‐stimulating hormone, and inhibin B.MethodsSecondary cross‐sectional analysis of data and serum obtained in Time to Conceive, a prospective cohort study sample of 843 women attempting pregnancy in central North Carolina from 2008 to 2016. Participants were aged 30 and 44 years, had no history of infertility, endometriosis, or polycystic ovarian syndrome, and were not currently breastfeeding. Serum samples were obtained on days 2, 3, or 4 of the menstrual cycle. C‐reactive protein (natural‐log transformed), Anti‐Müllerian hormone (natural‐log transformed), follicle‐stimulating hormone (natural‐log transformed), and inhibin B (untransformed) were measured in serum. Diminished ovarian reserve was examined dichotomously and defined as an Anti‐Müllerian hormone level below 0.7 ng/mL.ResultsThe analysis included 703 participants with C‐reactive protein measured. In an adjusted linear regression model, a 20% increase in C‐reactive protein was associated with a 0.57 pg/mL decrease in inhibin B (95% CI: −0.84 to −0.29 pg/mL) and a 0.535% decrease in follicle‐stimulating hormone (95% CI: −1.01 to −0.06). Although there was not a significant relationship between Anti‐Müllerian hormone and C‐reactive protein, a 20% increase in C‐reactive protein was associated with a 0.87% increase in Anti‐Müllerian hormone (95% CI: −0.27 to 2.01). C‐reactive protein was not associated with the odds of diminished ovarian reserve in an adjusted logistic regression model (OR: 0.97, 95% CI: 0.77–1.20).ConclusionsInflammation, as measured by C‐reactive protein, is associated with early follicular phase follicle‐stimulating hormone and inhibin B, although this is not true of AMH. Inflammation may exert an effect on ovarian function.
Regulating Interfacial Hydrogen‐Bonding Networks by Implanting Cu Sites with Perfluorooctane to Accelerate CO2 Electroreduction to Ethanol
Authors: Zhou Jing , He Bingling , Huang Pu , Wang Dongge , Zhuang Zechao , Xu Jing , Pan Chengsi , Dong Yuming , Wang Dingsheng , Wang Yao , Huang Hongwen , Zhang Jiawei , Zhu Yongfa 
Published: December 2024

AbstractEfficient CO2 electroreduction (CO2RR) to ethanol holds promise to generate value‐added chemicals and harness renewable energy simultaneously. Yet, it remains an ongoing challenge due to the competition with thermodynamically more preferred ethylene production. Herein, we presented a CO2 reduction predilection switch from ethylene to ethanol (ethanol‐to‐ethylene ratio of ~5.4) by inherently implanting Cu sites with perfluorooctane to create interfacial noncovalent interactions. The 1.83 %F‐Cu2O organic–inorganic hybrids (OIHs) exhibited an extraordinary ethanol faradaic efficiency (FEethanol) of ∼55.2 %, with an impressive ethanol partial current density of 166 mA cm−2 and excellent robustness over 60 hours of continuous operation. This exceptional performance ranks our 1.83 %F‐Cu2O OIHs among the best‐performing ethanol‐oriented CO2RR electrocatalysts. Our findings identified that C8F18 could strengthen the interfacial hydrogen bonding connectivity, which consequently promotes the generation of active hydrogen species and preferentially favors the hydrogenation of *CHCOH to *CHCHOH, thus switching the reaction from ethylene‐preferred to ethanol‐oriented. The presented investigations highlight opportunities for using noncovalent interactions to tune the selectivity of CO2 electroreduction to ethanol, bringing it closer to practical implementation requirements.
Abnormal Freezing Effect on Electron Conduction of Ball‐milled Lanthanum Trihydride for Superionic Conductor
Authors: Zhang Weijin , Wang Shangshang , Liu Shukun , Cui Jirong , Chen Hetong , Zou Ren , Xia Yuanhua , Cao Hujun , Chen Ping 
Published: December 2024

AbstractA recent finding shows that lattice deformation could transform the mixed electronic/hydride (H−) conducting lanthanum trihydride (LaH3) to a superionic H− conductor. Such a feature would enable the development of a brand‐new all‐solid‐state hydride ion battery. It is essential to elucidate the mechanism of such a phenomenon. Here, we disclose an abnormal freezing effect on the electronic conductivity (σe) of the ball‐milled LaH3; that is, σe can be lowered by over 2 orders of magnitude upon a low‐temperature treatment. Low‐temperature Raman reveals that at low temperatures, lattice deformation has a noticeable influence on the interaction of hydrogen at octahedral (Ho) and tetrahedral (Ht) sites, which may play a crucial role in hindering electron conduction. This freezing effect can significantly improve the ionic transfer number of rare earth‐based H− conductors and provide a new direction to the development of solid electrolytes for low‐temperature all‐solid‐state batteries.
High‐Performance Solution‐Processable Organic Light‐Emitting Diode Based on a Narrowband Near‐Ultraviolet Emitter and a Hot Exciton Strategy
Authors: Jiang Kai , Chang Xiang , Zhu Jieqiong , Zhu Tian , Yu Junting , Wang Yafei , Zhang Youming , Ma Dongge , Zhu Weiguo 
Published: December 2024

AbstractAchieving high efficiency narrowband near‐ultraviolet (NUV) emitters in organic light emitting diode (OLED) is still a formidable challenge. Herein, a proof‐of‐concept hybridized local and charge transfer (HLCT) molecule, named ICz‐BO, is prepared and characterized, in which both multiresonant (MR) skeletons are integrated via conjugation connection. A slightly distorted structure and weak intramolecular charge transfer (CT) interaction between two MR subunits lead to a high‐lying reverse intersystem crossing (h‐RISC) channel of T6→S1, also evidenced by both experimental and calculated results. Impressively, the ICz‐BO emitter exhibits outstanding narrowband NUV emission at 404 nm with a full‐width at half maximum of 28 nm in toluene solution. The solution processable OLED shows an excellent device performance with the recorded maximum external quantum efficiency of 12.01 %, concomitant with an extremely low y‐axis Commission Internationale de l’Éclairage (CIEy) value of 0.031. To the best of our knowledge, this is the highest efficiency reported for the HLCT‐based NUV‐OLEDs to date. This research proves that the MR skeleton plays a positive effect on the narrowband hot exciton emitter, which provides an alternative paradigm for developing high‐efficiency NUV emitters.
Clinical, Immunologic, and Genetic Characteristics in Patients With Syndrome of Undifferentiated Recurrent Fevers
Authors: Macaraeg Marci , Baker Elizabeth , Handorf Elizabeth , Matt Michael , Baker Elizabeth K. , Brunner Hermine , Grom Alexei A. , Henrickson Michael , Huggins Jennifer , Zhang Wenying , Lee Pui , Marsh Rebecca , Schulert Grant S. 
Published: December 2024

ObjectiveSyndrome of undifferentiated recurrent fevers (SURF) is characterized by recurrent fevers and autoinflammation without a confirmed molecular diagnosis of a hereditary recurrent fever syndrome, and not fulfilling criteria for periodic fever, adenitis, pharyngitis, aphthous stomatitis syndrome (PFAPA). The goal of this study was to characterize clinical features of patients with SURF compared to patients with PFAPA and to analyze their cytokine signature, genetic variations, and responses to treatment.MethodsWe enrolled 46 patients observed at Cincinnati Children's Hospital Medical Center. Baseline data and inflammatory cytokines were collected at enrollment, and their clinical course was followed. Cytokine analysis was performed using a cytokine multiplex assay. Many patients had specific or whole exome genetic testing.ResultsThe prevalence of rash and arthralgias were higher in patients with SURF compared to patients with PFAPA. Pharyngitis and adenopathy were less frequent. A subset of patients with SURF clustered together with elevated proinflammatory cytokines and more frequently required biologic therapy. Focused analysis of whole exome sequencing data revealed that variants of unknown clinical significance (VUCS) were frequently identified in genes implicated in B cell development, immunodeficiencies, and inflammatory bowel disease risk. Treatments for patients with SURF commonly included on‐demand steroids, colchicine, and anti–interleukin‐1 therapy.ConclusionOur findings suggest SURF is a heterogeneous group but has distinct clinical and immunologic features from disorders such as PFAPA. Patients have frequent VUCS, which may have relevance to disease pathogenesis. A subset of patients showed more inflammation and an increased need for biologic therapy. Further research is necessary to define whether there exist distinct SURF endotypes and to better predict treatment outcomes.
Multiple Carbazole‐Benzonitrile (CzBN) Derived TADF Molecules Targeting Efficient and Stable Blue OLEDs
Authors: Zhang Hai , Duan Lian , Zhang Dongdong 
Published: December 2024

AbstractThermally activated delayed fluorescence (TADF) materials have emerged as a promising avenue for developing efficient and stable blue organic light‐emitting diodes (OLEDs) without incorporating heavy metals. Among the numerous donor‐acceptor architectures explored, the carbazole (Cz) and benzonitrile (BN) combination has demonstrated exceptional potential for blue OLED applications. Herein, we delve into the recent advances in TADF materials based on the Cz‐BN framework, with a particular focus on design strategies to accelerate exciton dynamics and improve material stability through kinetic and thermodynamic optimization. Eventually, challenges associated with the Cz‐BN systems in blue OLEDs, as well as prospective research directions that could unlock the full potential of this intriguing category of materials, are also discussed.
Materialminimierte Rippen‐ und Wabendecken aus extrudierten Carbonbetonstegen
Authors: Morales Cruz Cynthia , Bosbach Sven , Kalthoff Matthias , Beckmann Birgit , Matschei Thomas , Classen Martin 
Published: December 2024

AbstractUm den Ressourcenverbrauch und den CO2‐Fußabdruck der Bauwirtschaft zu reduzieren, sind neue Konstruktionsprinzipien erforderlich, die einen minimalen Materialeinsatz ermöglichen. Besonders bei Wänden, Decken und Fundamenten, die mehr als 60 % des weltweit verwendeten Gesamtvolumens an Beton ausmachen, besteht ein hohes Potenzial zur Einsparung von Material und CO2‐Emissionen. Ein vielversprechender Ansatz ist der Einsatz von Carbonbewehrung, da diese aufgrund ihrer Korrosionsbeständigkeit eine geringere Betondeckung benötigt. In Bezug auf die Topologie des Bauteils wurden seit Jahrzehnten materialeffiziente Rippen‐ oder Waffelplatten gebaut. Jedoch werden diese aufgrund der arbeitsintensiven Herstellung in Europa nicht oft eingesetzt. Ein kürzlich entwickeltes Extrusionsfertigungsverfahren ermöglicht die schnelle schalungsfreie Herstellung von Carbonbetonstegen, die als Halbzeuge für die serielle Fertigung ein‐ und zweiachsig gespannter Deckensysteme eingesetzt werden können. Teile der Arbeiten zum Extrusionsprozess wurden bereits in [1] vorgestellt und werden in dem vorliegenden Beitrag genutzt, um neuartige materialminimierte Rippen‐ und Wabendeckenentwürfe aus vorgefertigten extrudierten Carbonbetonstegen bzw. ‐waben zu realisieren. Zudem wird ein Ausblick auf die großtechnische Herstellung von ein‐ und zweiachsigen Plattensystemen wie Rippen‐, Waffel‐ und Sandwichplatten mit Wabenstruktur im Großformat gegeben.
Sustainability Discourses in the Leadership and Management Literature: A Critical Review
Authors: Toft Kristian Høyer , Hansen Morten Balle 
Published: December 2024

ABSTRACTThis review advances a critical discussion of prevalent sustainability discourses in the leadership and management literature. Since the 1990s, ecocentric approaches to management have been discussed in opposition to anthropocentric (human centered) management theory. However, limited attention has been given, so far, to clarifying how sustainability discourses have influenced the literature of leadership and management. The influence of rights‐based United Nations Sustainable Development dating back to the Brundtland report in 1987 is widely recognized, as are business and technology‐based discourses in sustainability (ecological modernism). Such discourses are united in a belief in green growth. However, a literature review shows that critical sustainability discourses about limits to growth, planetary boundaries and the need for degrowth, as well as ecocentric discourses, are only marginally present in the literature on leadership and management. In view of the need for leadership to address the “polycrisis” of entangled environmental and social crises, we problematize the lack of critical sustainability discourses in the leadership and management literature.
Nicotinamide N‐methyltransferase negatively regulates metastasis‐promoting property of cancer‐associated fibroblasts in lung adenocarcinoma
Authors: Wang Peiyu , Wang Guangxi , Li Haoran , Yuan Yuyao , Chen Haiming , Wang Shaodong , Sun Zewen , Meng Fanjie , Li Yun , Yang Fan , Wang Jun , Chen Kezhong , Qiu Mantang 
Published: December 2024

AbstractBackgroundRecurrence and metastasis remain significant challenges in lung adenocarcinoma (LUAD) after radical resection. The mechanisms behind the recurrence and metastasis of LUAD remain elusive, and deregulated cellular metabolism is suspected to play a significant role. This study explores the metabolic and epigenetic regulation mediated by nicotinamide N‐methyl transferase (NNMT) in LUAD.MethodsUntargeted metabolomic analyses were performed to detect metabolism irregularities. Single‐cell RNA sequencing (RNA‐seq) databases and multiplex immunofluorescence analysis were used to identify the location of NNMT within the tumor microenvironment. The biological functions of NNMT were investigated both in vitro and in vivo, with RNA‐seq and chromatin immunoprecipitation‐PCR providing insights into underlying mechanisms. Finally, single‐cell RNA‐seq data and immunohistochemistry of primary tumors were analyzed to validate the main findings.ResultsUntargeted metabolomic analyses revealed metabolic aberrations in amino acids, organic acids, lipids, and nicotinamide pathways, which are linked to metastasis of non‐small cell lung cancer. NNMT is a key enzyme in nicotinamide metabolism, and we found the bulk tissue mRNA level of NNMT gene was inversely associated with LUAD metastasis. NNMT was proved to be predominantly expressed in cancer‐associated fibroblasts (CAFs) within the stromal regions of LUAD, and a low stromal NNMT expression was identified as a predictor of poor disease‐free survival following radical resection of LUAD. The isolation and primary culture of CAFs from LUAD enabled in vitro and in vivo experiments, which confirmed that NNMT negatively regulated the metastasis‐promoting properties of CAFs in LUAD. Mechanistically, the downregulation of NNMT led to an increase in intracellular methyl groups by reducing the activity of the methionine cycle, resulting in heightened methylation at H3K4me3. This alteration triggered the upregulation of genes involved in extracellular matrix remodeling in CAFs, including those encoding collagens, integrins, laminins, and matrix metalloproteinases, thereby facilitating cancer cell invasion and metastasis. Reanalysis of single‐cell RNA‐seq data and immunohistochemistry assays of primary LUAD tissues substantiated NNMT's negative regulation of these genes in CAFs.ConclusionsThis study provides novel insights into the metabolic and epigenetic regulatory functions of NNMT in CAFs, expanding the current understanding of LUAD metastasis regulation and suggesting potential avenues for future research and therapeutic development.
Subtype‐specific transcription factors affect polyamine metabolism and the tumor microenvironment in breast cancer
Authors: Song Qi , Wang Yixuan , Liu Sen 
Published: December 2024

AbstractBackgroundPolyamines play important roles in cell growth and proliferation. Polyamine metabolism genes are dysregulated in various tumors. Some polyamine metabolism genes are regulated by transcription factors. However, the transcription factors that regulate polyamine metabolism genes have not been completely identified. Additionally, whether any of the transcriptional regulations depend on tumor heterogeneity and the tumor microenvironment has not been investigated.MethodsWe used bulk RNA‐seq data to identify dysregulated polyamine metabolism genes and their transcription factors across breast cancer subtypes. Genes highly correlated with polyamine changes were obtained, and their subtype‐specific expressions were checked in tumor microenvironment cells using single‐cell RNA (scRNA)‐seq data. Gene Ontology enrichment analysis was used to explore their molecular functions and biological processes, and survival analysis was used to examine the impact of these genes on therapeutic outcome.ResultsWe first analyzed the dysregulation of polyamine synthesis, catabolism, and transport in four breast cancer subtypes. Genes such as AGMAT and CAV1 were dysregulated across all subtypes, while APRT, SAT1, and other genes were dysregulated in the more lethal subtypes. Among the dysregulated genes of polyamine metabolism, we focused on three genes (SRM, APRT, and SAT1) and identified their transcription factors (SPI1 and IRF1 correspond to SAT1, and IRF3 corresponds to SRM and APRT). With scRNA‐seq data, we verified that these three transcription factors also regulated these three polyamine metabolism genes in the tumor microenvironment. Both bulk RNA‐seq and scRNA‐seq data indicated that these genes were specifically upregulated in high‐risk breast cancer subtypes, such as the basal‐like type. High expression of these genes corresponded to worse outcomes in the basal‐like subtype under chemotherapy and radiation treatment.ConclusionOur work identified three subtype‐specific transcription factors that regulate three polyamine metabolism genes in high‐risk breast cancer subtypes and the tumor microenvironment. Our results deepen the understanding of the role of polyamine metabolism in breast cancer and may help the clinical therapy of advanced breast cancer subtypes.
Bucking Mid‐Life Inactivity: How Social Identity Processes Facilitate Zwift Participation for Mid‐Life Adults
Authors: Richards Toby , Day Melissa , Slater Matthew J. , Easterbrook Matthew J. , Figgins Sean G. 
Published: December 2024

ABSTRACTWhile physical activity generally declines in middle‐aged adults, group exercise participation among 40‐64‐year‐old is increasing. This rise may be due to the accessibility of online group exercise formats and their ability to reflect members' identities. This research explores how social identification processes facilitate participation in Zwift, an online group exercise platform. Seventeen Zwift participants aged 40–64 were recruited for three data collection stages: (1) an initial semi‐structured interview on exercise history and Zwift usage; (2) a two‐week post‐exercise diary capturing social identification experiences; and (3) a follow‐up interview to discuss topics from the first two stages. Data were analysed using abductive thematic analysis. Zwift supports three levels of social identity abstraction: (1) Identity Continuity, maintaining a cyclist identity through online cycling; (2) A Compatible New Identity as a Zwifter, formed through group interaction and social support; and (3) New Group Membership, developed through in‐team belonging, recognition, and social status. Mid‐life is a period of transition and identity change. Findings in this study suggest four ways that online platforms could facilitate social identification within online exercise platforms, namely (a) empower selection via perceived life‐stage similarity and age, (b) enable ‘digital proximity’ via text chat and participant on‐screen avatars, (c) enable the common fate of shared real‐time exercise experiences, and (d) facilitate interaction and belonging via a pre and post‐exercise ‘digital clubhouse’ via a social media page.
Insecticidal Activity of Fatty Acids From the Fruit Extract of Momordica cymbalaria Fenzl Ex Naudin, Has Insecticidal Activities on Mosquito Larvae
Authors: Monika Subramanian , Lavanya Mathiazhakan , Sethuraman Veeran , Arunthirumeni Murugan , Selvam Kuppusamy , Shivakumar Muthugounder Subramanian 
Published: December 2024

ABSTRACTThe fruit and other parts of Momordica cymbalaria are known to have medicinal properties. The study investigates the chemical composition and functional groups of M. cymbalaria fruits to assess the insecticidal potential of its bioactive metabolites. In silico approach was used to understand the mechanism behind the insecticidal nature of these metabolites. Ethyl acetate extract has 18 compounds, whereas 20 compounds were identified in methanol using gas chromatography–mass spectroscopy analysis. The extracts contain several functional groups, including alkanes, esters, carboxylic acids, amides and aromatic groups. The insecticidal bioassay using methanol and ethyl acetate extracts of M. cymbalaria on Aedes aegypti and Culex quinquefasciatus mosquito larvae shows that the LC50 value for A. aegypti was 65.7 ppm, for C. quinquefasciatus was 96.9 ppm and for ethyl acetate and methanol extract is 282.36 and 388.09 ppm. Molecular docking of secondary metabolites was performed with five insect proteins, namely, odorant binding protein (OBP), cytochrome P450 (CYP450), prophenol oxidase (PPO), arylalkylamine n‐acetyltransferease (aaNAT) and sterol carrier protein (SCP). Results show that methyl 6‐cis, 9‐cis, 11‐trans‐octadecatrienoate has high binding affinity with sterol carrier protein (SCP‐2) besides showing binding with other insect proteins. The data suggest that methyl 6‐cis, 9‐cis, 11‐trans‐octadecatrienoate has multiple insecticidal actions and may serve as a green insecticide.
A Multiscale Mathematical Model for Fetal Gas Transport and Regulatory Systems During Second Half of Pregnancy
Authors: Van Willigen Bettine G. , van der Hout‐van der Jagt M. Beatrijs , Huberts Wouter , van de Vosse Frans N. 
Published: December 2024

ABSTRACTFetal asphyxia, a condition resulting from the combined effects of hypoxia and hypercapnia, leads to approximately 900,000 annual deaths worldwide. One cause is umbilical cord compression during labor‐induced uterine contractions, disrupting the transport of metabolites to and from the placenta, and resulting in asphyxia. Current fetal well‐being assessment relies on monitoring fetal heart rate and uterine contractions as indicators of oxygen delivery to the brain. To enhance our understanding of this complex relationship, this study aims to develop a modular mathematical model including fetal blood gas dynamics, the autonomic nervous system, and cerebral blood flow regulation. The novelty of this study lies in the capability of the model to simulate fetal growth. These submodels are part of a larger multiscale mathematical model describing fetal circulation in the second half of pregnancy. The blood gas model realistically replicates partial oxygen and carbon dioxide pressures in umbilical arteries and veins during healthy fetal development reported in the literature. An in silico experiment is conducted to simulate umbilical cord occlusion and is compared with lamb experiments to verify the realism of the regulation models during fetal growth. Our findings suggest that premature infants are more susceptible to umbilical cord occlusion, exhibiting elevated cerebral perfusion pressure and flow. This modular mathematical model may serve as a valuable tool for testing hypotheses related to the fetal regulatory system.