bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data‐Driven Materials Exploration for Li‐Ion Conductive Ceramics by Exhaustive and Informatics‐Aided Computations
Authors: Nakayama Masanobu , Kanamori Kenta , Nakano Koki , Jalem Randy , Takeuchi Ichiro , Yamasaki Hisatsugu 
Published: November 2018

AbstractInterest in all‐solid‐state Li‐ion batteries (LIBs) using non‐flammable Li‐conducting ceramics as solid electrolytes has increased, as safe and robust batteries are urgently desired as power sources for (hybrid) electric vehicles. However, the low Li‐ion conductivities of ceramics have hindered all‐solid‐state LIB commercialization; many researchers have attempted to develop fast Li‐ion conductors. We introduce two efficient high‐throughput computational approaches for materials exploration: (i) exhaustive search and (ii) informatics‐aided prediction. For demonstration, ∼400 Li‐ and Zn‐containing oxide (Li−Zn−X−O) compounds of varied crystal structures are extracted from Materials Project datasets. We calculate the migration energies for Li‐ion conduction and the phase stabilities (decomposition energies) of these materials by simulation and apply Bayesian optimization to determine the material with the highest ionic conductivity. The results show much greater efficiency than a random search algorithm.
Kaempferol suppresses cell migration through the activation of the ERK signaling pathways in ARPE‐19 cells
Authors: Chien Hsiang‐Wen , Wang Kai , Chang Yuan‐Yen , Hsieh Yi‐Hsien , Yu Nuo‐Yi , Yang Shun‐Fa , Lin Hui‐Wen 
Published: November 2018

AbstractKaempferol is a flavonoid with anticancer and anti‐metastasis activity in different cancer‐cell lines. However, the underlying mechanisms by which kaempferol acts on human retinal pigment epithelial (ARPE‐19) cells remain unclear. In this study, we demonstrated that kaempferol inhibited migration and invasion in ARPE‐19 cells at non‐toxic dosages. We discovered that kaempferol obviously reduced the enzyme activity and protein expression of matrix metalloproteinase‐2 by increasing the phosphorylated levels of extracellular signal‐regulated kinases 1/2 (ERK1/2) signaling pathways. Additionally, ERK1/2‐specific inhibitor PD98059 significantly reversed kaempferol's inhibitory effects on migration and expression of MMP‐2 in ARPE‐19 cells. Overall, our results are the first to demonstrate that kaempferol is capable of inhibiting cell migration by targeting ERK1/2 signaling in human retinal pigment epithelial cells.
Gendered Effects of Home-Based Work on Parents’ Capability to Balance Work with Non-work: Two Countries with Different Models of Division of Labour Compared
Authors: Kurowska Anna 
Published: November 2018

AbstractThis paper explores gendered impact of home-based work (HBW) on the capability to balance work with non-work in double-earner families with dependent children in two countries with distinct models of division of labour: Poland and Sweden. At first, I critically engage with the WLB conceptualization in HBW studies and try to address identified gaps. Driving from the theoretical concept of ‘burden of responsibilities’ and setting it in the capability approach, I propose to operationalize the capability to balance work with non-work as a latent construct, observed through two indicators of the burden of unpaid work responsibilities related to one’s engagement in paid work. To simultaneously measure this capability as a latent construct and the impact of HBW on this capability, I estimate a simple structural equation model for each country. The results show that men in both countries have higher capabilities to balance work with non-work than women, but the difference between genders is smaller in Sweden. I also find that HBW is related to lower capability to balance work with non-work for mothers in both countries and for fathers in Sweden only. The results of this study show that in a relatively gender equal society (Sweden) the negative impact of home based work on the capability to balance work with non-work affects both genders. On the contrary—in a more traditional society (Poland), men are able to ‘escape’ the trap of double burden of paid and unpaid work when working from home while women do not.
Psychometric properties of the Swedish version of the Ego Resilience scale (ER) and a new shortened version of the Ego Undercontrol Scale (EUC)
Authors: Isaksson Martina , Ghaderi Ata , Wolf-Arehult Martina , Ramklint Mia 
Published: November 2018

AbstractThe Ego Resilience scale (ER) and The Ego Undercontrol scale (EUC) are designed to assess personality types based on how people inhibit or express their emotional impulses. The study aim was to evaluate the psychometric properties of the Swedish version of both scales. Two community samples were recruited through convenience sampling and were informed about the study either while attending an undergraduate class at University or through advertisement on the Internet. For the two samples respectively, 483 and 197 individuals aged 18–70 completed the self-rating questionnaires via a website. In the first sample, factor structure, internal consistency, test-retest reliability and construct validity of the ER and the EUC were evaluated and a shorter version of the EUC (EUC-13) was developed based on the outcome. In the second sample, factor structure and psychometric properties of the EUC-13 were analyzed. Exploratory and confirmatory factor analysis supported both the original version of the ER and the EUC-13. Both instruments showed satisfactory levels of internal consistency for all subscales but Socially restrained behavior from the EUC-13, good test-retest reliability, as well as satisfactory preliminary evidence of validity. Further validation studies are recommended, such as investigating the scales in clinical settings.
Modelling multiply connected heterogeneous objects using mixed-dimensional material reference features
Authors: Sharma G.K. , Gurumoorthy B. 
Published: November 2018

Abstract
This paper proposes a general method for ab-initio modelling and representation of heterogeneous objects that are associated with complex material variation over complex geometry.
Heterogeneous objects like composites and naturally occurring objects (bones, rocks and meteorites) possess multiple and often conflicting properties (like high hardness and toughness simultaneously), which are associated with random and irregular material distribution. Modelling such objects is desired for numerical analysis and additive manufacturing to develop bio-implants, high-performance tools etc. However, it is difficult to define and map the arbitrary material distribution within the object as the material distribution can be independent of the shape parameters or form features used to construct its solid model.
This paper represents the source of random and irregular material distribution by mixed-dimensional entities with a focus on modelling compositional heterogeneity. The domain of effect of each material reference entity is defined automatically by using Medial Axis Transform (MAT), where the material distribution can be intuitively prescribed, starting from the material reference entity and terminating at the medial axis segment bounding the corresponding domain. Within such a domain, the spatial variation of the material is captured by a distance field from the material reference entity, which can be controlled locally and independently. These domains are stored using the neighbourhood relation for efficient operations like altering material distribution across the material reference entity and material evaluation for a given geometric location. Results from an implementation for 2.5D objects are shown and the extension to 3D objects is discussed.
Highlights Hybrid representation for complex heterogeneous objects. General method for ab-initio modelling of complex heterogeneous objects capture arbitrary material distribution by automatic domain decomposition. Local control of material composition through MAT around material feature. Specification of material composition without adding new entities to shape model.
Aeolian Material Transport and Its Role in Landscape Connectivity in the McMurdo Dry Valleys, Antarctica
Authors: Diaz Melisa A. , Adams Byron J. , Welch Kathleen A. , Welch Susan A. , Opiyo Stephen O. , Khan Alia L. , McKnight Diane M. , Cary S. Craig , Lyons W. Berry 
Published: November 2018

AbstractArid regions, particularly polar and alpine desert environments, have diminished landscape connectivity compared to temperate regions due to limited and/or seasonal hydrological processes. For these environments, aeolian processes play a particularly important role in landscape evolution and biotic community vitality through nutrient and solute additions. The McMurdo Dry Valleys (MDV) are the largest ice‐free area in Antarctica and are potentially a major source of aeolian material for the continent. From this region, samples were collected at five heights (~5, 10, 20, 50, and 100 cm) above the surface seasonally for 2013 through 2015 from Alatna Valley, Victoria Valley, Miers Valley, and Taylor Valley (Taylor Glacier, East Lake Bonney, F6 (Lake Fryxell), and Explorer's Cove). Despite significant geological separation and varying glacial histories, low‐elevation and coastal sites had similar major ion chemistries, as did high‐elevation and inland locations. This locational clustering of compositions was also evident in scanning electron microscopy images and principal component analyses, particularly for samples collected at ~100 cm above the surface. Compared to published soil literature, aeolian material in Taylor Valley demonstrates a primarily down‐valley transport of material toward the coast. Soluble N:P ratios in the aeolian material reflect relative nutrient enrichments seen in MDV soils and lakes, where younger, coastal soils are relatively N depleted, while older, up‐valley soils are relatively P depleted. The aeolian transport of materials, including water‐soluble nutrients, is an important vector of connectivity within the MDV and provides a mechanism to help “homogenize” the geochemistry of both soil and aquatic ecosystems.
Rapid Loss of Relativistic Electrons by EMIC Waves in the Outer Radiation Belt Observed by Arase, Van Allen Probes, and the PWING Ground Stations
Authors: Kurita S. , Miyoshi Y. , Shiokawa K. , Higashio N. , Mitani T. , Takashima T. , Matsuoka A. , Shinohara I. , Kletzing C. A. , Blake J. B. , Claudepierre S. G. , Connors M. , Oyama S. , Nagatsuma T. , Sakaguchi K. , Baishev D. , Otsuka Y. 
Published: November 2018

AbstractThere has been increasing evidence for pitch angle scattering of relativistic electrons by electromagnetic ion cyclotron (EMIC) waves. Theoretical studies have predicted that the loss time scale of MeV electrons by EMIC waves can be very fast, suggesting that MeV electron fluxes rapidly decrease in association with the EMIC wave activity. This study reports on a unique event of MeV electron loss induced by EMIC waves based on Arase, Van Allen Probes, and ground‐based network observations. Arase observed a signature of MeV electron loss by EMIC waves, and the satellite and ground‐based observations constrained spatial‐temporal variations of the EMIC wave activity during the loss event. Multisatellite observation of MeV electron fluxes showed that ~2.5‐MeV electron fluxes substantially decreased within a few tens of minutes where the EMIC waves were present. The present study provides an observational estimate of the loss time scale of MeV electrons by EMIC waves.
Sand Suspension and Transport During Inundation of a Dutch Barrier Island
Authors: Engelstad A. , Ruessink B. G. , Hoekstra P. , van der Vegt M. 
Published: November 2018

Overwash and inundation of barrier islands transport large amounts of sediment landward, which could potentially increase the aggradation of these islands in times of sea level rise. However, not much is known about the detailed processes of sediment suspension and transport during inundation. Here we analyze field data of suspended sediment, water levels, waves, and currents which were collected during five inundation events on a barrier island in the Netherlands. We found that depth‐integrated suspended sand concentrations and cross‐shore sand transport showed high variability during and between inundation events at our location, where 80% of the combined transport from all inundation events was completed before high tide. This is primarily caused by variations in cross‐shore flow velocities which were strongest (up to 1.2 m/s onshore) before high tide. However, episodically high depth‐integrated suspended sand concentrations (defined as >2kg/m2) were observed on infragravity time scales (∼20–200 s), suggesting that the contribution of infragravity waves to the combined bed shear stresses of waves and currents was important. High contributions of infragravity waves to the transport coincided with observed bore‐like wave shapes, which might partly be attributed to higher short waves riding and suspending sediment at the position of the crest. Two transport regimes were thus found to govern the transport during inundation: a flow‐driven regime when flow velocities were high (>0.5 m/s) and the ratio of infragravity wave and current related shields numbers was below 0.11 and an episodic regime when this ratio exceeded 0.11.
Insensitivity of the Cloud Response to Surface Warming Under Radical Changes to Boundary Layer Turbulence and Cloud Microphysics: Results From the Ultraparameterized CAM
Authors: Parishani Hossein , Pritchard Michael S. , Bretherton Christopher S. , Terai Christopher R. , Wyant Matthew C. , Khairoutdinov Marat , Singh Balwinder 
Published: November 2018

AbstractWe study the cloud response to a +4K surface warming in a new multiscale climate model that uses enough interior resolution to begin explicitly resolving boundary layer turbulence (i.e., ultraparameterization or UP). UP's predictions are compared against those from standard superparameterization (SP). The mean cloud radiative effect feedback turns out to be remarkably neutral across all of our simulations, despite some radical changes in both cloud microphysical parameter settings and cloud‐resolving model grid resolution. The overall low cloud response to warming is a positive low cloud feedback over land, a negative feedback (driven by cloud optical depth increase) at high latitudes, and weak feedback over the low‐latitude oceans. The most distinct effects of UP result from tuning decisions impacting high‐latitude cloud feedback. UP's microphysics is tuned to optimize the model present‐day, top‐of‐atmosphere radiation fluxes against CERES observations, by lowering the cloud ice‐liquid phase shift temperature ramp, adjusting the ice/liquid autoconversion rate, and increasing the ice fall speed. This reduces high‐latitude low cloud amounts and damps the optical depth feedback at high latitudes, leading to a slightly more positive global cloud feedback compared to SP. A sensitivity test that isolates these microphysical impacts from UP's grid resolution confirms that the microphysical settings are mostly responsible for the differences between SP and UP cloud feedback.
Improving Assimilation of Radiance Observations by Implementing Model Space Localization in an Ensemble Kalman Filter
Authors: Lei Lili , Whitaker Jeffrey S. , Bishop Craig 
Published: November 2018

AbstractExperiments using the National Oceanic and Atmospheric Administration Finite‐Volume Cubed‐Sphere Dynamical Core Global Forecasting System (FV3GFS) reveal that the four‐dimensional ensemble‐variational method (4DEnVAR) performs similarly to an ensemble Kalman filter (EnKF) when no radiance observations are assimilated, but 4DEnVAR is superior to an EnKF when radiance observations are assimilated. The hypothesis for the cause of the differences between 4DEnVAR and EnKF is the difference in vertical localization, since radiance observations are integral observations in the vertical and 4DEnVAR uses model space localization while the EnKF uses observation space localization. A modulation approach, which generates an expanded ensemble from the raw ensemble and eigenvectors of the localization matrix, has been adopted to implement model space localization in the operational National Oceanic and Atmospheric Administration EnKF. As constructed, the expanded ensemble is a square root of the vertically localized background error covariance matrix, so no explicit vertical localization is necessary during the EnKF update. The size of the expanded ensemble is proportional to the rank of the vertical localization matrix—for a vertical localization scale of 1.5 (3.0) scale heights, 12 (7) eigenvectors explain 96% of the variance of the localization matrix, so the expanded ensemble is 12 (7) times larger than the raw ensemble. Results from assimilating only radiance observations in the FV3GFS model confirm that EnKF with model‐space vertical localization performs better than observation‐space localization, and produces results similar to 4DEnVAR. Moreover, a 960‐member ensemble is sufficient to turn off the vertical localization entirely and yields significant improvements comparing to an 80‐member ensemble with model space localization.
Predicting geogenic Arsenic in Drinking Water Wells in Glacial Aquifers, North‐Central USA: Accounting for Depth‐Dependent Features
Authors: Erickson M. L. , Elliott S. M. , Christenson C. A. , Krall A. L. 
Published: November 2018

AbstractChronic exposure to arsenic (As) via drinking groundwater is a human health concern worldwide. Probabilities of elevated geogenic As concentrations in groundwater were predicted in complex, glacial aquifers in Minnesota, north‐central USA, a region that commonly has elevated As concentrations in well water. Maps of elevated As hazard were created for depths typical of drinking water supply and with well construction attributes common for domestic wells. Conventional variables describing aquifer properties and materials, position on the hydrologic landscape, and soil geochemistry were among the most influential for predicting the probability of elevated As. We also found that certain well construction attributes were influential in predicting As hazard. Smaller distances between the top of the well screen and overlying aquitard (proximity) and shorter well screen lengths were each associated with higher probabilities of elevated As. Influential predictor variables, which are either mapped across the region or are well construction attributes, are proxies in the model for measurable physical or geochemical causes of elevated As (e.g., redox condition, till or aquifer sediment chemistry, and water chemistry), which are not mapped across the region. Our setting shares some important characteristics with deltaic and other high‐As aquifers in Southeast Asia: late Quaternary age, complex layering of coarse‐ and fine‐grained materials, low‐As sediment concentrations, and geochemical controls on As mobilization. Translating three‐dimensional geologic and geochemical understanding of As mobility to quantifiable variables for modeling with powerful, flexible statistical tools could improve predictions and help identify safer groundwater supply options in the USA, Southeast Asia, and elsewhere.
Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling
Authors: Xiao Yongtao , Zhou Kejun , Lu Ying , Yan Weihui , Cai Wei , Wang Ying 
Published: November 2018

AbstractThe link between antibiotic treatment and IF-associated liver disease (IFALD) is unclear. Here, we study the effect of antibiotic treatment on bile acid (BA) metabolism and investigate the involved mechanisms. The results showed that pediatric IF patients with cholestasis had a significantly lower abundance of BA-biotransforming bacteria than patients without cholestasis. In addition, the BA composition was altered in the serum, feces, and liver of pediatric IF patients with cholestasis, as reflected by the increased proportion of primary BAs. In the ileum, farnesoid X receptor (FXR) expression was reduced in patients with cholestasis. Correspondingly, the serum FGF19 levels decreased significantly in patients with cholestasis. In the liver, the expression of the rate-limiting enzyme in bile salt synthesis, cytochrome P450 7a1 (CYP7A1), increased noticeably in IF patients with cholestasis. In mice, we showed that oral antibiotics (gentamicin, GM or vancomycin, VCM) reduced colonic microbial diversity, with a decrease in both Gram-negative bacteria (GM affectedEubacteriumandBacteroides) and Gram-positive bacteria (VCM affectedClostridium,BifidobacteriumandLactobacillus). Concomitantly, treatment with GM or VCM decreased secondary BAs in the colonic contents, with a simultaneous increase in primary BAs in plasma. Moreover, the changes in the colonic BA profile especially that of tauro-beta-muricholic acid (TβMCA), were predominantly associated with the inhibition of the FXR and further altered BA synthesis and transport. In conclusion, the administration of antibiotics significantly decreased the intestinal microbiota diversity and subsequently altered the BA composition. The alterations in BA composition contributed to cholestasis in IF patients by regulating FXR signaling.
Bridging reproductive and microbial ecology: a case study in arbuscular mycorrhizal fungi
Authors: Aguilar-Trigueros Carlos A , Hempel Stefan , Powell Jeff R , Cornwell William K , Rillig Matthias C 
Published: November 2018

Abstract
Offspring size is a key trait for understanding the reproductive ecology of species, yet studies addressing the ecological meaning of offspring size have so far been limited to macro-organisms. We consider this a missed opportunity in microbial ecology and provide what we believe is the first formal study of offspring-size variation in microbes using reproductive models developed for macro-organisms. We mapped the entire distribution of fungal spore size in the arbuscular mycorrhizal (AM) fungi (subphylum Glomeromycotina) and tested allometric expectations of this trait to offspring (spore) output and body size. Our results reveal a potential paradox in the reproductive ecology of AM fungi: while large spore-size variation is maintained through evolutionary time (independent of body size), increases in spore size trade off with spore output. That is, parental mycelia of large-spored species produce fewer spores and thus may have a fitness disadvantage compared to small-spored species. The persistence of the large-spore strategy, despite this apparent fitness disadvantage, suggests the existence of advantages to large-spored species that could manifest later in fungal life history. Thus, we consider that solving this paradox opens the door to fruitful future research establishing the relationship between offspring size and other AM life history traits.
Manipulating and monitoring nanoparticles in micellar thin film superstructures
Authors: ten Hove Jan Bart , van Leeuwen Fijs W. B. , Velders Aldrik H. 
Published: November 2018

AbstractUnderstanding the dynamics of discrete self-assembled structures under influence of external triggers is of interest to harvest the potential of nano- and mesoscale materials. In particular, controlling the hierarchical organization of (macro)molecular and nanoparticle building blocks in monolayer superstructures is of paramount importance for tuning properties and characteristics. Here we show how the electron beam in cryo-transmission electron microscopy can be exploited to induce and follow local migration of building blocks and global migration of micellar aggregates inside micrometer-sized superstructures. We employ stroboscopic exposure to heat up and convert the vitrified superstructure into a liquid-like thin film under cryogenic conditions, resulting in controlled evaporation of water that finally leads to rupture of the micelle-containing superstructure. Micelle-embedded nanoparticles prove a powerful tool to study the complex hierarchically built-up superstructures, and to visualize both global movement of individual dendrimicelles and local migration of nanoparticles inside the micellar core during the exposure series.