bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three‐dimensional quantitative analysis of healthy foot shape: a proof of concept study
Authors: Stanković Kristina , Booth Brian G. , Danckaers Femke , Burg Fien , Vermaelen Philippe , Duerinck Saartje , Sijbers Jan , Huysmans Toon 
Published: March 2018

AbstractBackgroundFoot morphology has received increasing attention from both biomechanics researches and footwear manufacturers. Usually, the morphology of the foot is quantified by 2D footprints. However, footprint quantification ignores the foot's vertical dimension and hence, does not allow accurate quantification of complex 3D foot shape.MethodsThe shape variation of healthy 3D feet in a population of 31 adult women and 31 adult men who live in Belgium was studied using geometric morphometric methods. The effect of different factors such as sex, age, shoe size, frequency of sport activity, Body Mass Index (BMI), foot asymmetry, and foot loading on foot shape was investigated. Correlation between these factors and foot shape was examined using multivariate linear regression.ResultsThe complex nature of a foot's 3D shape leads to high variability in healthy populations. After normalizing for scale, the major axes of variation in foot morphology are (in order of decreasing variance): arch height, combined ball width and inter‐toe distance, global foot width, hallux bone orientation (valgus‐varus), foot type (e.g. Egyptian, Greek), and midfoot width. These first six modes of variation capture 92.59% of the total shape variation. Higher BMI results in increased ankle width, Achilles tendon width, heel width and a thicker forefoot along the dorsoplantar axis. Age was found to be associated with heel width, Achilles tendon width, toe height and hallux orientation. A bigger shoe size was found to be associated with a narrow Achilles tendon, a hallux varus, a narrow heel, heel expansion along the posterior direction, and a lower arch compared to smaller shoe size. Sex was found to be associated with differences in ankle width, Achilles tendon width, and heel width. Frequency of sport activity was associated with Achilles tendon width and toe height.ConclusionA detailed analysis of the 3D foot shape, allowed by geometric morphometrics, provides insights in foot variations in three dimensions that can not be obtained from 2D footprints. These insights could be applied in various scientific disciplines, including orthotics and shoe design.
Dual infections of two carbapenemase-producing Acinetobacter baumannii clinical strains isolated from the same blood culture sample of a patient in Iran
Authors: Hadjadj Linda , Shoja Saeed , Diene Seydina M. , Rolain Jean-Marc 
Published: March 2018

AbstractIn this study, the draft genome sequences of two different carbapenem-resistant Acinetobacter baumannii clinical strains isolated from the same blood culture sample of an Iranian patient were determined. The strain A. baumannii 554S harbouring blaoxa72 gene belonged to ST 307 whereas A. baumannii 554L carrying blaoxa23 gene belonged to ST 2. We found that this sample contains two different isolates of A. baumannii, each phenotypically and genetically different.
The effect of serum types on Chondrogenic differentiation of adipose-derived stem cells
Authors: Cho Hyeran , Lee Aeri , Kim Kyobum 
Published: March 2018

Abstract

Background
Fetal bovine serum (FBS) is the most essential supplement in culture media for cellular proliferation, metabolism, and differentiation. However, due to a limited supply and subsequently rising prices, a series of studies have investigated a biological feasibility of replaceable serums to substitute FBS. Along with the increasing interests to manufacture stem cell-based cellular products, optimizing the composition of culture media including serums and exogenous growth factors (GFs) is of importance. In this experiment, the effect of bovine serum (BS) and newborn calf serum (NCS) on proliferation and chondrogenic differentiation capacity of human adipose derived stem cells (ADSCs) was evaluated, especially in the chondrogenically supplemented culture condition.

Methods
ADSCs were chondrogenically cultured with FBS, BS, and NCS for 14 days. For the acceleration of in vitro chondrogenesis, exogenous insulin-like growth factor and transforming growth factor-β3 were added. Viability and proliferation of ADSCs were evaluated using Live/Dead fluorescence staining and DNA amount, respectively. To investigate a chondrogenic differentiation, a series of assays were performed including a quantification of glycosaminoglycan deposition, alcian blue staining, and RT-PCR analysis for type II collagen, aggrecan and Sox-9 genes.

Results
The results demonstrated that proliferation of ADSCs was facilitated in FBS condition as compared with other serum types. For chondrogenic marker gene expression, serum substitutes enhanced Sox-9 expression level on day 14. The deposition of glycosaminoglycan was more facilitated in BS condition regardless of additional chondrogenic GFs.

Conclusion
It could be presumably speculated that serum types and exogenous supplements of GFs could also be important parameters to optimize culture media composition, especially in order to maintain the enhanced levels of both proliferation and chondrogenic differentiation of ADSCs during expansion.
Fast least-squares reverse time migration of VSP free-surface multiples with dynamic phase-encoding schemes
Authors: Liu Xuejian , Liu Yike , Khan Majid 
Published: March 2018

For vertical seismic profile (VSP), free-surface multiples can provide much wider subsurface illumination when compared with primaries. However, migration of multiple reflections generates not only the desired image of reflection interfaces but also many crosstalk artifacts. Therefore, the least-squares reverse time migration method is used to image the VSP downgoing free-surface multiples (receiver-side ghosts) and iteratively suppress crosstalks, in which full downgoing data (including direct waves) and downgoing multiples are used as sources and observed data, respectively. To reduce the computational cost, we have developed the simultaneous imaging of different common-receiver gathers that are dynamically blended together with iterations through the altered realizations of the phase-encoding function. Relative to the popular encoding function with a combination of random time delays and polarities, only the random polarities can be applied for further increasing the computational efficiency. Synthetic experiments on Sigsbee2B and Pluto1.5 models indicate that the proposed method can effectively eliminate crosstalk artifacts and improve imaging resolution while calculated even more efficiently than reverse time migration of VSP ghosts.
Source signature encoding of a vertical source array to separate the emitted direct wave from its ghost
Authors: Mueller Moritz B. , Halliday David F. , van Manen Dirk-Jan , Robertsson Johan O. A. 
Published: March 2018

Marine air-gun sources can be sequence-encoded by firing their individual elements independently over a short period of time. Using near-orthogonal firing sequences, whose crosscorrelation is minimal, as encoding sequences for multiple sets of air-gun sources, enables us to exploit their orthogonality as a separation feature. We find that, by distributing air guns over depths from 5 to 30 m, firing sequences can be designed whose direct, down-going wavefield is close to orthogonal to its source-ghost wavefield. The fundamentally new aspect of this approach is that the source-ghost signal is no longer just a time-delayed, opposite-polarity version of the down-going wavefield, but due to the different air-gun depths results in a different source sequence. This enables the consideration of the ghost wavefield as a separate source. We generate a set of such firing sequences by minimizing the crosscorrelation of these wavefields and optimizing their respective autocorrelations to achieve sharp peaks. The obtained, optimized firing sequences are then used for marine seismic source encoding. By adapting a multifrequency algorithm originally developed for simultaneous source separation, we determine that the ghost-source wavefield can be separated as a separate source from the direct, down-going wavefield.
“It Used to Be Forbidden”
Authors: Schäfers Marlene 
Published: March 2018

AbstractWomen’s rights and human rights projects in Turkey and elsewhere routinely construe and celebrate subaltern voice as an index of individual and collective empowerment. Through an ethnographic study of Kurdish women singers’ (dengbêjs) efforts to engage in their storytelling art in Turkey, this article questions the equation between “raising one’s voice” and having agency. It investigates two concrete instances in 2012, in Istanbul and Van, where Kurdish women publicly raised their voices. It shows that public audibility does not necessarily translate into agency, because these spaces, like most, discipline voices ideologically and sonically. Audibility is not a neutral achievement but an ideologically structured terrain that shapes voices and regulates whether and how they are heard and recognized. Voices routinely have ambiguous and even contradictory effects once they become audible in public. It is not simply a matter of “having voice” or “being silenced.”
Aspirational Maternalism and the “Reconstitution” of Single Mothers in Morocco
Authors: Newman Jessica Marie 
Published: March 2018

AbstractThis article interrogates how employees at single-mother associations in Morocco construct the mère célibataire (single mother) as an archetypal, aspirational figure. Based on two years of ethnographic fieldwork (2013–15), this article traces how counselors work with single mothers to imagine alternative maternal futures. I argue that by invoking a counternarrative I call “aspirational maternalism,” single-mother advocates disrupt traditional maternalist rhetoric that excludes single women. Aspirational maternalism draws on moral discourses and neoliberal values of independence and responsibility. Through its deployment, counselors create affective space for single mothers to think beyond pathologizing portrayals of single motherhood in Morocco. Counselors also disrupt the neoliberal focus on calculated, self-interested action by centering “the mother-child couple” within aspirational maternalism. The ideal-typical Mère Célibataire is capable of achieving the transformation from victim to self-sovereign mother. And yet, aspirational maternalism elides the significant structural obstacles to independence that single mothers face.
Domestic Economies
Authors: Rosenbaum Susanna 
Published: March 2018

In Domestic Economies, Susanna Rosenbaum examines how two groups of women—Mexican and Central American domestic workers and the predominantly white, middle-class women who employ them—seek to achieve the "American Dream." By juxtaposing their understandings and experiences, she illustrates how immigrant and native-born women strive to reach that ideal, how each group is indispensable to the other's quest, and what a vital role reproductive labor plays in this pursuit. Through in-depth ethnographic research with these women at work, at home, and in the urban spaces of Los Angeles, Rosenbaum positions domestic service as an intimate relationship that reveals two versions of female personhood. Throughout, Rosenbaum underscores the extent to which the ideology of the American Dream is racialized and gendered, exposing how the struggle for personal worth and social recognition is shaped at the intersection of motherhood and paid employment.
Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond
Authors: Liu Chun , Oikonomopoulos Angelos , Sayed Nazish , Wu Joseph C. 
Published: March 2018

ABSTRACT
The advent of human induced pluripotent stem cells (iPSCs) presents unprecedented opportunities to model human diseases. Differentiated cells derived from iPSCs in two-dimensional (2D) monolayers have proven to be a relatively simple tool for exploring disease pathogenesis and underlying mechanisms. In this Spotlight article, we discuss the progress and limitations of the current 2D iPSC disease-modeling platform, as well as recent advancements in the development of human iPSC models that mimic in vivo tissues and organs at the three-dimensional (3D) level. Recent bioengineering approaches have begun to combine different 3D organoid types into a single ‘4D multi-organ system’. We summarize the advantages of this approach and speculate on the future role of 4D multi-organ systems in human disease modeling.
Nesprins and opposing microtubule motors generate a point force that drives directional nuclear motion in migrating neurons
Authors: Wu You Kure , Umeshima Hiroki , Kurisu Junko , Kengaku Mineko 
Published: March 2018

ABSTRACT
Nuclear migration of newly born neurons is essential for cortex formation in the brain. The nucleus is translocated by actin and microtubules, yet the actual force generated by the interplay of these cytoskeletons remains elusive. High-resolution time-lapse observation of migrating murine cerebellar granule cells revealed that the nucleus actively rotates along the direction of its translocation, independently of centrosome motion. Pharmacological and molecular perturbation indicated that spin torque is primarily generated by microtubule motors through the LINC complex in the absence of actomyosin contractility. In contrast to the prevailing view that microtubules are uniformly oriented around the nucleus, we observed that the perinuclear microtubule arrays are of mixed polarity and both cytoplasmic dynein complex and kinesin-1 are required for nuclear rotation. Kinesin-1 can exert a point force on the nuclear envelope via association with nesprins, and loss of kinesin-1 causes failure in neuronal migration in vivo. Thus, microtubules steer the nucleus and drive its rotation and translocation via a dynamic, focal interaction of nesprins with kinesin-1 and dynein, and this is necessary for neuronal migration during brain development.
Optical Properties of Trinuclear Citrate Complexes Containing 4f and 5f Block Metals
Authors: Aoyagi Noboru , Palladino Giuseppe , Nagasaki Shinya , Kimura Takaumi 
Published: March 2018

AbstractThe speciation and coordination geometries of M(III)-citrate complexes in aqueous solutions, where M denotes Eu, Tb, Lu, or Cm, are studied using potentiometric titration, 1H, and 13C nuclear magnetic resonance spectroscopies. Their photophysical properties are also characterized by time-resolved fluorescence spectra. The formation constants of mononuclear, dinuclear, and trinuclear Lu-citrate species, i.e., [Lu(Cit)2]3−, [Lu2(OH)2(Cit)2]2−, and [Lu3(OH)4(Cit)4]7−, were determined as 9.78 ± 0.30, 3.60 ± 0.30, and 1.02 ± 0.03, respectively, by potentiometric titration in 3.00 M NaClO4 aqueous media. Terminal carboxylic conformation in trinuclear complexes comprised both the five- and six-membered rings at different exchanging rates. Hydration states evaluated for Eu3+ ions are the chemical formula of [Eu(Cit)2(H2O)2.5]3− and [Eu3(OH)4(Cit)4(H2O)3.4]7−. These complexes in aqueous solution have geometrical similarity to the crystal structures in the literature. Furthermore, the entity of the hetero-trinuclear complex induces the intramolecular energy transfer from Tb3+ to Eu3+. The incorporation of Cm3+ into these homo/hetero-trinuclear citrate complexes proved to be a successful trial to probe the formation of actinide polymer at a trace level.
Electrocatalytic Hydrogenation of Toluene Using a Proton Exchange Membrane Reactor: Influence of Catalyst Materials on Product Selectivity
Authors: Fukazawa Atsushi , Takano Ken , Matsumura Yoshimasa , Nagasawa Kensaku , Mitsushima Shigenori , Atobe Mahito 
Published: March 2018

Abstract
We have investigated the electrochemical hydrogenation of toluene using a PEM reactor for development of an organic chemical hydride system. Especially, the influence of catalyst materials such as Pt, Ru, and PtRu for a PEM reactor on the by-product formation and product selectivity in the hydrogenation of toluene was investigated.
Prepregnancy Fitness and Risk of Gestational Diabetes: A Longitudinal Analysis
Authors: WHITAKER KARA M. , INGRAM KATHERINE H. , APPIAH DUKE , NICHOLSON WANDA K. , BENNETT WENDY L. , LEWIS CORA E. , REIS JARED P. , SCHREINER PAMELA J. , GUNDERSON ERICA P. 
Published: March 2018

ABSTRACT

Purpose
This study aimed to assess the associations of prepregnancy cardiorespiratory fitness, moderate- to vigorous-intensity physical activity (MVPA), and time spent watching television with subsequent development of gestational diabetes mellitus (GDM).

Methods
Participants were 1333 women enrolled in the Coronary Artery Risk Development in Young Adults study who did not have diabetes either at baseline (1985–86) or before births occurring after baseline. Baseline fitness was estimated using a graded symptom-limited maximal exercise treadmill test and expressed in MET units. Baseline MVPA (exercise units per day) was measured using the Coronary Artery Risk Development in Young Adults physical activity history questionnaire, and television viewing (h·d−1) was assessed by self-report in 1990–1991. Logistic regression analysis was used to derive odds ratios and 95% confidence intervals, adjusting for time from baseline to delivery and baseline study center, age, race, education, parity, family history of diabetes, smoking, alcohol, saturated fat intake, waist circumference, homeostasis model assessment of insulin resistance, and HDL cholesterol.

Results
Over 25 yr of follow-up, 164 women developed GDM. The odds of developing GDM were 21% lower for each 1 SD increment in baseline level of fitness (2.3 METs, odds ratio = 0.79, 95% confidence interval = 0.65–0.96). Prepregnancy MVPA and television viewing were not statistically associated with the development of GDM.

Conclusion
Study findings indicate that objectively assessed prepregnancy fitness, but not self-reported MVPA or television time, is associated with GDM. Clinicians should counsel women on the benefits of improving fitness in the preconception period, particularly among women at greater risk for GDM.
Insulin resistance indices and coronary risk in adults from Maracaibo city, Venezuela: A cross sectional study
Authors: Salazar Juan , Bermúdez Valmore , Olivar Luis Carlos , Torres Wheeler , Palmar Jim , Añez Roberto , Ordoñez Maria Gratzia , Rivas José Ramón , Martínez María Sofía , Hernández Juan Diego , Graterol Modesto , Rojas Joselyn 
Published: March 2018

Background: Insulin resistance (IR) is a metabolic disorder related to atherosclerosis. Its measurement is of great importance not only as a marker of diabetes but also for cardiovascular disease. The aim of this research study was to evaluate the relationship between various IR indices and coronary risk in an adult population from Maracaibo city, Venezuela. Methods: The Maracaibo City Metabolic Syndrome Prevalence Study is a descriptive, cross-sectional study with random and multi-stage sampling. In this sub study, 1272 individuals of both genders were selected with the measurement of basal insulin and coronary risk according to the Framingham-Wilson formula calibrated for our population. The insulin resistance indices evaluated were HOMA2-IR, triglycerides and glucose index (TyG) and triglycerides/HDL ratio (TG/HDL). The predictive capacity and association between each index and the coronary risk event in 10 years were determined. Results: Of the evaluated population, 55.2% were female, 34.8% had a coronary risk ≥5% in 10 years, with the TG/HDL and TyG indices showing the highest AUC 0.712 (0.681-0.743) and 0.707 (0.675-0.739), respectively; compared to HOMA2-IR. Both were also the indices most associated with increased coronary risk, especially TG/HDL ≥3 with a higher association [OR = 2.83 (1.74-4.61); p<0.01] after multivariable adjustment. Conclusions: TyG (≥4.5) and TG/HDL (≥3) indices showed a great predictive capacity of higher coronary risk, with being TG/HDL more associated even after adjusting for abdominal obesity and hs-CRP. Therefore, these represent useful tools for determining IR.
Fixed vs. Flexible Pricing in a Competitive Market
Authors: Selcuk Cemil , Gokpinar Bilal 
Published: March 2018

We study the selection and dynamics of two popular pricing policies—fixed price and flexible price—in competitive markets. Our paper extends previous work in marketing, for example, Desai and Purohit (2004) by focusing on decentralized markets with a dynamic and fully competitive framework while also considering possible noneconomic aspects of bargaining. We construct and analyze a competitive search model, which allows us to endogenize the expected demand depending on pricing rules and posted prices. Our analysis reveals that fixed and flexible pricing policies generally coexist in the same marketplace, and each policy comes with its own list price and customer demographics. More specifically, if customers dislike haggling, then fixed pricing emerges as the unique equilibrium, but if customers get some additional satisfaction from the bargaining process, then both policies are offered, and the unique equilibrium exhibits full segmentation: haggler customers avoid fixed-price firms and exclusively shop at flexible firms, whereas nonhaggler customers do the opposite. We also find that prices increase in customer satisfaction, implying that sellers take advantage of the positive utility enjoyed by hagglers in the form of higher prices. Finally, considering the presence of seasonal cycles in most markets, we analyze a scenario in which market demand goes through periodic ups and downs and find that equilibrium prices remain mostly stable despite significant fluctuations in demand. This finding suggests a plausible competition-based explanation for the stability of prices. The online appendix is available at https://doi.org/10.1287/mnsc.2017.2922 . This paper was accepted by J. Miguel Villas-Boas, marketing.