bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Single-Nucleotide Polymorphisms in Monoubiquitinated FANCD2-DNA Damage Repair Pathway Genes With Breast Cancer in the Chinese Population
Authors: Chen Fei-Yu , Wang Hao , Li Hui , Hu Xue-Li , Dai Xu , Wang Shou-Man , Yan Guo-Jiao , Jiang Ping-Lan , Hu Yuan-Ping , Huang Juan , Tang Li-Li 
Published: December 2018

Objective: The aim of the study was to estimate breast cancer risk conferred by individual single-nucleotide polymorphisms of breast cancer susceptibility genes. Methods: We analyzed the 48 tagging single-nucleotide polymorphisms of 8 breast cancer susceptibility genes involved in the monoubiquitinated FANCD2–DNA damage repair pathway in 734 Chinese women with breast cancer and 672 age-matched healthy controls. Results: Forty-five tagging single-nucleotide polymorphisms were successfully genotyped by SNPscan, and the call rates for each tagging single-nucleotide polymorphisms were above 98.9%. We found that 13 tagging single-nucleotide polymorphisms of 5 genes ( Parter and localizer of Breast cancer gene2 ( PALB2), Tumour protein 53 ( TP53), Nijmegen breakage syndrome 1, Phosphatase and tensin homolog deleted from chromosome 10 ( PTEN), and Breast cancer gene 1 ( BRCA1-interacting protein 1)) were significantly associated with breast cancer risk. A total of 5 tagging single-nucleotide polymorphisms (rs2299941 of PTEN, rs2735385, rs6999227, rs1805812, and rs1061302 of Nijmegen breakage syndrome 1) were tightly associated with breast cancer risk in sporadic cases, and 5 other tagging single-nucleotide polymorphisms (rs1042522 of TP53, rs2735343 of PTEN, rs7220719, rs16945628, and rs11871753 of BRCA1-interacting protein 1) were tightly associated with breast cancer risk in familial and early-onset cases. Conclusions: Some of the tagging single-nucleotide polymorphisms of 5 genes ( PALB2, TP53, Nijmegen breakage syndrome 1, PTEN, and BRCA1-interacting protein 1) involved in the monoubiquitinated FANCD2–DNA damage repair pathway were significantly associated with breast cancer risk.
The puzzle of sex, gender and Alzheimer’s disease: Why are women more often affected than men?
Authors: Andrew Melissa K , Tierney Mary C 
Published: December 2018

Objective: There are impressive differences in the incidence, prevalence and experience of women and men with Alzheimer’s Disease (AD). Notably, two-thirds of those with AD, the most common form of dementia, are women. Our objective was to provide a literature-based framework to understand these sex and gender differences in AD. Methods: We conducted a narrative review to examine sex and gender influences on AD. Results: We present a framework to understanding why these sex and gender differences exist in AD. This includes the influence of longevity (women live longer than men), biological differences (hormonal differences, epigenetics and frailty), differences in cognitive performance (women and men tend to perform differently on some cognitive tests), and gendered social roles and opportunities (educational and occupational opportunities, functional roles post-retirement). Our review clearly indicates the complex interaction of these sex and gender differences and variability within each. Conclusions: Given these important sex and gender differences in AD, we provide recommendations and steps forward describing how both sex and gender should be considered in dementia diagnosis and management and in the design and implementation of dementia research, including studies of caregiving interventions and models of dementia care.
User Experiences of an Electronic Personal Health Record for Diabetes
Authors: Conway Nicholas Thomas , Allardice Brian , Wake Deborah Jane , Cunningham Scott Gordon 
Published: December 2018

Background: My Diabetes My Way (MDMW) is an electronic personal health record (ePHR) that provides access to educational resources and clinical data to people with diabetes in Scotland. This questionnaire study aims to assess user experience, barriers to access, and inform future development. Methods: All active MDMW users (n = 3797) were invited to complete an online questionnaire in May 2015, surveying usage patterns and system utility. A “utility score” was calculated, based on responses to Likert-scale questions and used as the dependent variable within regression analysis, with demographic features as independent predictors. Free-text responses were analyzed thematically and presented using descriptive statistics. Results: A total of 1095/3797 (27.5%) active users completed the survey. Of them, 690/1095 (63%) were male. There was representation of all age and socioeconomic groups. Respondents were positive regarding the system utility, which met expectations. The majority of respondents believed that online access to diabetes information has the potential to improve diabetes self-care within the population. The most valued features were personal clinical data associated visualizations. Th main problems cited were data accuracy and system access (ie, log-in procedure). Perceived usefulness of the system was inversely associated with duration of diabetes, which was the only significant predictor of utility score. Conclusions: This study has demonstrated that MDMW users find the system useful in supporting diabetes self-management. The system was found to have greatest utility among those most recently diagnosed with diabetes. This study has informed further development of the service, including enhancing data visualization and the need to improve access to the system.
Ivacaftor, a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, Enhances Ciprofloxacin Activity Against Pseudomonas aeruginosa
Authors: Cho Do-Yeon , Lim Dong Jin , Mackey Calvin , Skinner Daniel , Zhang Shaoyan , McCormick Justin , Woodworth Bradford A. 
Published: December 2018

Background Methods to improve the clinical efficacy of currently available antibiotics against multidrug resistant bacteria in cystic fibrosis (CF) chronic rhinosinusitis (CRS) are greatly needed. Ivacaftor, a cystic fibrosis transmembrane conductance regulator potentiator, was recently identified as having potentially beneficial off-target effects as a weak inhibitor of bacterial DNA gyrase and topoisomerase IV. The objective of the current study is to evaluate whether ivacaftor enhances the antimicrobial activity of ciprofloxacin against Pseudomonas aeruginosa. Methods The planktonic growth of the PAO-1 strain of P. aeruginosa was studied in the presence of ciprofloxacin and/or ivacaftor. Effects were measured according to optical density of cultured PAO-1 at 600 nm. For a static PAO-1 biofilm assay, the PAO-1 strain was inoculated and cultured for 72 h in the presence of the drugs. Formed PAO-1 biofilms were quantified by crystal violet staining and imaged with confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM). Results PAO-1 growth was significantly reduced in the presence of ivacaftor (8 or 16 µg/mL) and ciprofloxacin (0.02 or 0.05 µg/mL) compared to ciprofloxacin alone ( P < .001). Similarly, ivacaftor (8 or 16 µg/mL) showed a significant reduction of PAO-1 biofilms when treated with 0.05 µg/mL of ciprofloxacin. Significant synergism was noted between ciprofloxacin and 16 µg/mL of ivacaftor ( P < .0001) in reducing planktonic growth and biofilm formation. Quantitative measurements with crystal violet staining were correlated to CLSM and SEM images. Conclusion Ivacaftor enhanced ciprofloxacin’s antimicrobial activity against P. aeruginosa. Further studies evaluating the efficacy of ivacaftor/ciprofloxacin combination for P. aeruginosa for CF CRS are warranted.
Identification and targeting of novel CDK9 complexes in acute myeloid leukemia
Authors: Beauchamp Elspeth M. , Abedin Sameem M. , Radecki Sara G. , Fischietti Mariafausta , Arslan Ahmet Dirim , Blyth Gavin T. , Yang Angela , Lantz Connor , Nelson Alissa , Goo Young Ah , Akpan Imo , Eklund Elizabeth A. , Frankfurt Olga , Fish Eleanor N. , Thomas Paul M. , Altman Jessica K. , Platanias Leonidas C. 
Published: December 2018

Abstract
Aberrant activation of mTOR signaling in acute myeloid leukemia (AML) results in a survival advantage that promotes the malignant phenotype. To improve our understanding of factors that contribute to mammalian target of rapamycin (mTOR) signaling activation and identify novel therapeutic targets, we searched for unique interactors of mTOR complexes through proteomics analyses. We identify cyclin dependent kinase 9 (CDK9) as a novel binding partner of the mTOR complex scaffold protein, mLST8. Our studies demonstrate that CDK9 is present in distinct mTOR-like (CTOR) complexes in the cytoplasm and nucleus. In the nucleus, CDK9 binds to RAPTOR and mLST8, forming CTORC1, to promote transcription of genes important for leukemogenesis. In the cytoplasm, CDK9 binds to RICTOR, SIN1, and mLST8, forming CTORC2, and controls messenger RNA (mRNA) translation through phosphorylation of LARP1 and rpS6. Pharmacological targeting of CTORC complexes results in suppression of growth of primitive human AML progenitors in vitro and elicits strong antileukemic responses in AML xenografts in vivo.
Cross-cultural Examination of Differences Regarding Eating Attitudes and Depression of International University Students
Authors: Okumusoglu Sultan 
Published: December 2018

<p style="text-align:justify">Globally increasing prevalence of eating disorders emphasizes the existence of eating psychopathologies across cultures. Investigating eating disorders and depression among emerging adults across ethnic/racial diversity is important regarding theory and interventions. Hence, examination of differences regarding eating attitudes and depression of international university students from Africa and Asia continents was aimed. “Eating Attitudes Test-26” (EAT-26) and “The Center for Epidemiologic Studies Depression Scale-Revised” (CESD-R) were used for data collection. Participants are 108 (84 Africans, 24 Asians) university students. Asian students’ and females’ EAT-26 scores were determined as higher. Regarding depression scores, %14,81 of the all participants (%8,3 of the African and %37,5 of the Asian students) were found above the pathological cut point. But no differences were detected between groups except ‘suicide ideas’. Disordered eating attitudes correlated positively with depressive tendencies and also with ‘sadness’, ‘tiredness’ and ‘suicide ideas’ besides compensating behaviors like ‘laxative diuretic usage’. Results demonstrated some practical and theoretical implications. As well as being consistent with cross-cultural findings regarding eating disorders, results seems consistent with the criteria and the related literature revealing co-existing symptoms of eating disorders, comorbidity between eating disorders and depression and also with Cognitive Theory.</p>
Food Cravings, Nutritional Status and Physical Activity in Patients with Major Depression in Turkey
Authors: Muftuoglu Selen , Kiziltan Gul , Ok Mehtap Akcil 
Published: December 2018

<p style="text-align:justify">Our goal was to determine food cravings, nutritional status and physical activity of patients diagnosed with major depression. The study was conducted on 203 (144 women, 59 men) patients, aged 20-64 years, who were diagnosed with major depression at three psychiatry centers. Anthropometric measurements, demographic data, current health status, depression duration, drug use, eating habits, food craving status (Food Craving Questionnaire-Trait/FCQ-T), food consumption frequency, energy and nutrient intake and physical activity level (International Physical Activity Questionnaire-Short Form/IPAQ) were evaluated. Depression duration, the frequency of antidepressant use and FCQ-T scores were higher in females than males. We found a positive correlation between FCQ-T score with the frequency of antidepressant use, depression duration and eating speed (p < 0.05). Also, depression duration was negatively correlated with folate, vitamin B6, vitamin C and zinc (p < 0.05). Lastly, depression duration and FCQ-T were positively correlated with body weight, body mass index, waist circumference, hip circumference, body fat (%) and fat tissue (kg) (p< 0.05). In addition, physical activity is a very important statement for FCQ-T scores. Both men and women, the risk of FCQ-T score who exercised for <600 Met-min/week were greater relative to that of those who exercised for ≥3000 Met-min/week. The results of this study showed that an inverse correlation between a number of nutrients intake and depression duration, antidepressant use or FCQ-T scores. It also emphasizes the beneficial effects of habitual exercise participation on food cravings. Future research exploring the nutritional status of individuals with depression is warranted.</p>
‘Darkness Turned into Power’: Drag as resistance in the era of Trumpian reversal
Authors: Greenhalgh Ella 
Published: December 2018

Abstract
In ‘Darkness Turned to Power’ Ella Greenhalgh unearths the role of the contemporary drag queen as a force of revitalized queer resistance in the United States. Beginning by tracing the political, cultural and social impact that Donald Trump’s election campaign and presidency has had on queer Americans thus far, Greenhalgh demonstrates that it is Trump’s toxic masculinity that creates a context in which drag is more obviously defiant. The role of drag as an innately resistive and political art form is acknowledged in drag’s long history. However, Greenhalgh goes on to portray modern drag as having greater power in political activism, with a greater mainstream public interest due, most notably, to the television show RuPaul’s Drag Race (2009–present, US: Logo and VH1). Three queens who use their drag to oppose Trump in differing ways are considered. She finds resistance emerges through direct action, interpretive art and dance, social media presence and straight-up mockery. While highlighting that drag is antithetical to the conservative world-view that considers binaries fundamental, Greenhalgh notes the inherent limitations within drag’s rise to the mainstream, concluding that if drag is ‘darkness turned into power’, drag artists must use this power to fight inclusively against the common enemy.
(Trans)gendering public toilets: Queering toilet humour in South Park’s ‘The Cissy’
Authors: Robbins Andrew 
Published: December 2018

Abstract
This article reads South Park’s episode ‘The Cissy’, which aired in 2014, to consider broader social discourse about gendered public toilet segregation in America. A resurgent interest in policing the borders of public toilets has led to the development of ‘bathroom bill’ legislation in some states. Given the unique challenges that this causes for elementary schools, South Park’s take on the practice of gendered toileting is deemed a relevant text. This article argues that ‘The Cissy’ queers the animation series’ own framework of toilet humour by using the toilet and its boundaries as a vehicle through which to explicate a position of transgender rights.
Reviews
Authors: Elrod James M. , González Octavio R. , Schippert Claudia 
Published: December 2018

Abstract
The New Gay for Pay: The Sexual Politics of American Television Production, Julia Himberg (2017) Austin: University of Texas Press, 202 pp., ISBN 978-1-47731-359-6, h/bk, $90.00; ISBN 978-1-47731-360-2, p/bk, $29.95
From Drag Queens to Leathermen: Language, Gender and Gay Male Subcultures, Rusty Barrett (2017) New York: Oxford University Press, 274 pp., ISBN 978-0-19539-017-9, h/bk, $99.00; ISBN 978-0-19539-018-6, p/bk, $24.95
Television Antiheroines: Women Behaving Badly in Crime and Prison Drama, Milly Buonanno (ed.) (2017) Bristol and Chicago: Intellect, 295 pp., ISBN: 978-1-78320-760-2, p/bk, $45.00
The ‘Ratio Legis’ of Article 177 of the Russian Criminal Code
Authors: ALLANINA Lilija M. , YUZIKHANOVA Elvira G. , KRETOVA Anastasia Yu. , IZUYMOV Igor V. , NASYROVA Nailja R. 
Published: December 2018

In the article the authors examine intersystem relations and problems of deliberate evasion of the repayment of debts of a large size, or from the payment for securities, after the entry into legal force of an appropriate court judgment. The author pay attention to the construction of the crime, actus reusand its characteristics and to the main categories: accounts payable, organization, organization's manager and malignance. The analysis of judicial practice and the theory is carried out too.
The phrase ‘accounts payable’ has some blurry boundaries, and as a result, it causes considerable difficulties in the qualification of the act.
It is concluded that that the criminological characteristics of accounts payable are much narrower in comparison with the generally accepted in the civil doctrine interpretation of an obligation. A similar situation is with the treatment of the notion ‘organization's manager’. The specific of the legal status of the manager is in the civil and employment law relationships, that indicates its complex nature.
In this regard, at least two elements of the corpus delictiprovided by Article 177 of the Criminal Code of the Russian Federation relating to the object and to the subject of the crime contain private-law characteristics. These characteristics have legal content and meanings which remain controversial, for theoretical and practical reasons. The civilized category ‘conscientiousness’ is the cornerstone of the concept ‘malignance’ in the civil law. The category ‘conscientiousness’ or ‘good conscience’ (‘bona fides’) is, in turn, of an evaluative nature and has the highest form of abstraction. In the opinion of the authors, the ‘ratio legis’ of the criminal structure of Article 177 of the Criminal Code, hidden behind evaluative categories, should be reflected in the real possibility to enforce the judicial act. The disposition of the norm implies that the implementation of final rulings should be taken into account. Therefore, malignance in the behavior of the debtor cannot be judged without taking into account the entire procedure to be followed in enforcement proceedings.
Kelime Başında Y Foneminin Düşmesi: Kâbûs-Nâme ve Türkiye Türkçesi Ağızları Örneği
Authors: BULDUK Türker Barış 
Published: December 2018

Ses, dili oluşturan
en küçük yapı taşıdır. Sesler bir araya gelerek heceleri ve heceler de
birleşerek kelimeleri oluşturur. Seslerdeki değişmeler, düşmeler ya da
türemeler kelimenin başında, ortasında ya da sonunda gerçekleşebilir. Bu durum
kelimelerin farklı söylenmesine ve zamanla da farklı yazılmasına neden
olabilir.

Türkçe, ses değişme, düşme ve
türemelerinin gerçekleştiği dillerden biridir. Çünkü Türkçe, kökü çok eski
tarihlere dayanan geçmişi boyunca geniş coğrafyalara yayılmış ender dillerden
biridir. Bu yayılım ve dilin doğasında bulunan canlı bir varlık olma vasfı,
Türkçenin dil özelliklerinin farklılaşmasında temel teşkil etmiştir.

y foneminin kelime başında düşmesi hadisesi Eski Türkçeden bugüne
Türkçede karşılaşılan önemli ses hadiselerinden biridir. Bu çalışmada, Türkiye
Türkçesi ağızlarının dil yapısı bakımından temel dayanağı kabul edilen Eski
Anadolu Türkçesi dönemi eserlerinden Kâbûs-nâme’deki kelime başındaki y foneminin düşmesi hadisesi
incelenerek, bu hadisenin Türkiye Türkçesi ağızlarındaki yansımaları tespit
edilecektir. Ayrıca, y foneminin
düştüğü kelimeler Türkiye Türkçesi ağız gruplarında incelenecek ve bu
kelimelerin tarihî Türk lehçelerindeki kullanımları üzerinde durulacaktır.
Pain-Related Fear—Dissociable Neural Sources of Different Fear Constructs
Authors: Meier Michael Lukas , Vrana Andrea , Humphreys Barry Kim , Seifritz Erich , Stämpfli Philipp , Schweinhardt Petra 
Published: December 2018

AbstractFear of pain demonstrates significant prognostic value regarding the development of persistent musculoskeletal pain and disability. Its assessment often relies on self-report measures of pain-related fear by a variety of questionnaires. However, based either on “fear of movement/(re)injury/kinesiophobia,” “fear avoidance beliefs,” or “pain anxiety,” pain-related fear constructs plausibly differ while it is unclear how specific the questionnaires are in assessing these different constructs. Furthermore, the relationship of pain-related fear to other anxiety measures such as state or trait anxiety remains ambiguous. Advances in neuroimaging such as machine learning on brain activity patterns recorded by functional magnetic resonance imaging might help to dissect commonalities or differences across pain-related fear constructs. We applied a pattern regression approach in 20 human patients with nonspecific chronic low back pain to reveal predictive relationships between fear-related neural pattern information and different pain-related fear questionnaires. More specifically, the applied multiple kernel learning approach allowed the generation of models to predict the questionnaire scores based on a hierarchical ranking of fear-related neural patterns induced by viewing videos of activities potentially harmful for the back. We sought to find evidence for or against overlapping pain-related fear constructs by comparing the questionnaire prediction models according to their predictive abilities and associated neural contributors. By demonstrating evidence of nonoverlapping neural predictors within fear-processing regions, the results underpin the diversity of pain-related fear constructs. This neuroscientific approach might ultimately help to further understand and dissect psychological pain-related fear constructs.
The Differences in Local Translatome across Distinct Neuron Types Is Mediated by Both Baseline Cellular Differences and Post-transcriptional Mechanisms
Authors: Ouwenga Rebecca , Lake Allison M. , Aryal Shivani , Lagunas Tomas , Dougherty Joseph D. 
Published: December 2018

AbstractLocal translation in neurites is a phenomenon that enhances the spatial segregation of proteins and their functions away from the cell body, yet it is unclear how local translation varies across neuronal cell types. Further, it is unclear whether differences in local translation across cell types simply reflect differences in transcription or whether there is also a cell type-specific post-transcriptional regulation of the location and translation of specific mRNAs. Most of the mRNAs discovered as being locally translated have been identified from hippocampal neurons because their laminar organization facilitates neurite-specific dissection and microscopy methods. Given the diversity of neurons across the brain, studies have not yet analyzed how locally translated mRNAs differ across cell types. Here, we used the SynapTRAP method to harvest two broad cell types in the mouse forebrain: GABAergic neurons and layer 5 projection neurons. While some transcripts overlap, the majority of the local translatome is not shared across these cell types. In addition to differences driven by baseline expression levels, some transcripts also exhibit cell type-specific post-transcriptional regulation. Finally, we provide evidence that GABAergic neurons specifically localize mRNAs for peptide neurotransmitters, including somatostatin and cortistatin, suggesting localized production of these key signaling molecules in the neurites of GABAergic neurons. Overall, this work suggests that differences in local translation in neurites across neuronal cell types are poised to contribute substantially to the heterogeneity in neuronal phenotypes.