bluuebunny/crossref_metadata_2025_split huggingface dataset:
Commissioning and implementation of a pencil‐beam algorithm with a Lorentz correction as a secondary dose calculation algorithm for an Elekta Unity 1.5T MR linear accelerator
Authors: Taneja Sameer , Wang Hesheng , Barbee David L. , Galavis Paulina , Sosa Mario Serrano , Byun David , Zelefsky Michael , Chen Ting 
Published: December 2024

AbstractPurposeTo commission a beam model in ClearCalc (Radformation Inc.) for use as a secondary dose calculation algorithm and to implement its use into an adaptive workflow for an MR‐linear accelerator.MethodsA beam model was developed using commissioning data for an Elekta Unity MR‐linear accelerator and entered into ClearCalc. The beam model consisted of absolute dose calculation settings, output factors, percent depth‐dose (PDD) curves, mutli‐leaf collimator (MLC) transmission and dose leaf gap error, and cryostat corrections. Beam profiles were hard‐coded by the manufacturer into the beam model and were compared with Monaco‐derived profiles. The beam model was tested by comparing point doses in a homogenous phantom obtained through measurements using an ionization chamber in water, Monaco, and ClearCalc for various field sizes, source‐surface distances (SSDs), and point locations. Additional testing including point dose verification for test plans using a heterogeneous phantom and patient plans. Post clinical implementation, performance of ClearCalc was evaluated for the first 41 patients treated, which included 215 adaptive plans.ResultsPDDs generated using ClearCalc fell within 1.2% of measurements. Field profile comparison between ClearCalc and Monaco showed an average pass rate of 98% using a 3%/3 mm gamma criteria. Measured cryostat corrections used in the beam model showed a maximum deviation from unity of 1.4%. Point dose and field monitor units (MUs) comparisons in a homogenous phantom (N = 22), heterogeneous phantoms (N = 22), and patient plans (N = 57) all passed with a threshold of 5%/5MU. Clinically, ClearCalc was implemented as a physics check post adaptive planning completed prior to beam delivery. Point dose and field MUs showed good agreement at a 5%/5MU threshold for prostate stereotactic body radiation therapy (SBRT), pelvic lymph nodes, rectum, and prostate and lymph node plans.DiscussionThis work demonstrated commissioning and clinical implementation of ClearCalc into an adaptive planning workflow. No primary or adaptive plan failures were reported with proper beam model testing.
Laser interstitial thermal therapy in the management of bottom‐of‐sulcus dysplasia‐related epilepsy
Authors: Yang Bowen , Zhang Chao , Wang Xiu , Zhao Baotian , Mo Jiajie , Luo Weiyuan , Shao Xiaoqiu , Zhang Jianguo , Zhang Kai , Hu Wenhan 
Published: December 2024

AbstractObjectiveThis study assessed the efficacy and safety of magnetic resonance‐guided laser interstitial thermal therapy (MRgLITT) versus open surgery (OS) for the treatment of patients with bottom‐of‐sulcus dysplasia (BOSD)‐related epilepsy.MethodsTwenty‐two patients underwent MRgLITT, while 39 underwent OS. Postoperative seizure‐free rates were analyzed using Kaplan–Meier curves. The removal ratio, which represents the extent of damage, was calculated based on preoperative lesion volume and postoperative removal volume. Other outcomes, including adverse events, operative time, and hospital stay, were also compared.ResultsKaplan–Meier curves indicated the seizure‐free rates were comparable between the MRgLITT group (90.9%, 26.5 [23.0, 35.1] months) and OS group (89.7%, 25.2 [16.2, 34.6] months) at the final follow‐up (p = 0.901, log‐rank test). The removal ratio of MRgLITT (1.3 [1.1, 1.7]) was significantly lower (p = 0.007) than that of OS (5.8 [3.6, 8.5]). A comparison of postoperative neurological deficits, infection rates, and fever rates revealed no significant differences between MRgLITT and OS groups. The operative time (hours) of MRgLITT (3.0, [2.1, 4.9]) was significantly shorter (p = 0.007) than that of OS (3.5 [3.0, 4.5]). The hospital stay (days) after MRgLITT (6 [5.0, 7.5]) was significantly shorter (p < 0.001) than that of OS (11.0 [9.0, 13.5]).InterpretationMRgLITT has advantages over OS, including comparable seizure control and adverse event profiles, along with reduced removal ratios, shorter operative time, and shorter hospital stays.
Electrochemical Reactivity and Stability of the Fe Electrode in Alkaline Electrolyte
Authors: Tan Shu Fen , Wu Hanglong , Manser Joseph S. , Zhang Duhan , Ronchi Maria , Smullin Sylvia , Chiang Yet‐Ming , Ross Frances M. 
Published: December 2024

AbstractFe anodes are emerging as cost‐effective components in long duration storage applications, with a benefit being the high natural abundance of Fe. Additive and electrode design have advanced the performance of Fe electrodes, but a more precise understanding of the electrode formation process and failure mechanisms is important for continued optimization. These interfacial electrochemical processes, which involve short‐lived intermediate species, require analysis with high spatial and temporal resolution to provide a full picture. This study therefore explores the behavior of the Fe electrode in alkaline electrolyte using electrochemical liquid cell transmission electron microscopy, extending the technique toward high pH (10–13) conditions. By combining identical location imaging and diffraction, in situ imaging, and benchtop experiments, this study shows distinct microstructural changes on cycling as a function of pH, in particular the appearance of multiple electrodeposited Fe species and a passivation layer. The dependence on electrochemical parameters is discussed, showing that the observations can be related to stability predictions from the Pourbaix diagram. However, it is also necessary to consider kinetic effects, such as the solubility and diffusion of soluble species. Strategies to control these material transformations are discussed as a function of potential, along with opportunities for further optimizing the Fe electrode.
Lysosomal Membrane‐Biomimetic Metal‐Organic Framework Potentiates Autophagy/Epigenetic‐Mediated Anti‐Tumor Immunity
Authors: Wang Yiqiao , Wang Zhihua , Han Mingda , Miao Qiannan , Shao Bingru , Wang Ning , Wang Jingying , Li Xiuan , Yan Fei , Feng Shouhua 
Published: December 2024

AbstractThe loss of major histocompatibility complex I (MHC‐I) in leukemia cells limits their recognition by T cells, leading to leukemia relapse and resistance to immunotherapy. MHC‐I molecules are often degraded by an autophagy‐dependent mechanism and are still considered “undruggable”. Herein, a lysosomal membranes‐based biomimetic metal‐organic framework (MOF) nanoplatforms (PFMALM) is reported. PFMALM is developed by coating a histone deacetylase inhibitor‐loaded MIL‐53(Fe) with lysosomal and leukemia cell membranes derived from the primary tissue. PFMALM is selectively taken up by the leukemia cells following targeted delivery to the leukemia microenvironment on account of the homing affinity of the leukemia cell membrane. Most importantly, PFMALM can not only upregulate MHC‐I transcripts via hyperacetylating histone H3 but also increase surface MHC‐I expression by protecting the MHC‐I from autophagy‐dependent lysosomal degradation. In addition, PFMALM increased global m6A RNA modification, leading to the transcriptional repression of the programmed death ligand 1 (PD‐L1). The increase in surface MHC‐I and reduction in PD‐L1 synergistically enhanced the recognition and clearance of leukemic cells by the cytotoxic T cells. PFMALM also exhibited a broad anti‐tumor activity in mouse models of leukemia, multiple myeloma, and breast cancer. This study provides proof‐of‐concept of a lysosomal‐based biomimetic nanoplatform as a novel epigenetic drug for broad‐spectrum anti‐tumor immunity.
3D Nanofabrication via Directed Material Assembly: Mechanism, Method, and Future
Authors: Gu Songyun , Chen Bingxu , Xu Xiayi , Han Fei , Chen Shih‐Chi 
Published: December 2024

AbstractFabrication of complex three‐dimensional (3D) structures at nanoscale is the core of nanotechnology, as it enables the creation of various micro‐/nano‐devices such as micro‐robots, metamaterials, sensors, photonic devices, etc. Among most 3D nanofabrication strategies, the guided material assembly, an efficient bottom‐up approach capable of directly constructing designed structures from precise integration of material building blocks, possesses compelling advantages in diverse material compatibility, sufficient driving forces, facile processing steps, and nanoscale resolution. In this review, we focus on assembly‐based fabrication methods capable of creating complex 3D nanostructures (instead of periodic or 2.5D‐only structures). Recent advances are classified based on the different assembly mechanisms, i.e., assembly driven by chemical reactions, physical interactions, and the synergy of multiple microscopic interactions. The design principles of representative fabrication strategies with an emphasis on their respective advantages, e.g., structural design flexibility, material compatibility, resolution, or applications are analyzed. In the summary and outlook, existing challenges, as well as possible paths to solutions for future development are reviewed. We believe that with recent advances in assembly‐based nanofabrication strategies, 3D nanofabrication has achieved tremendous progress in resolution, material generality, and manufacturing cost, for it to make a greater impact in the near future.
Army Ant Nest Inspired Adaptive Textile for Smart Thermal Regulation and Healthcare Monitoring
Authors: Chow Lung , Zhang Qiang , Huang Xingcan , Zhang Jun , Zhou Jingkun , Zhu Bo , Li Jiyu , Huang Ya , Zhang Binbin , Li Jian , Wu Pengcheng , Gao Yuyu , Gao Zhan , Zhao Guangyao , Yao Kuanming , Liu Yiming , Yip Joanne , Yang Zhihui , Yu Xinge 
Published: December 2024

AbstractA textile material that can dynamically adapt to different environments while serving as an immediate alert system for early detection of life‐threatening factors in the surroundings, not only enhances the individual's health management but also contributes to a reduction in energy consumption for space cooling and/or heating. In nature, different species have their own adaptation system to ambient temperature. Inspired by the army ant nest, herein a thermal adaptive textile known as Army ant Nest Textile (ANT) for thermal management and health monitoring is reported. This textile can promptly respond to perspiration, rapidly absorb sweat, and then transform its architecture to facilitate heat dissipation. Simultaneously, the colorimetric sensing function of ANT allows it to emulate the “site migration” behavior of the army ant nest, which empowers individuals to expeditiously identify multiple health‐related signals such as body temperature, UV radiation, and sweat pH values, and warn them to move to a secure environment, thereby effectively reducing the likelihood of physical harm. Together with its excellent scalability and biocompatibility, the ANT offers a promising direction for the development of next‐generation smart e‐textiles for personal thermal and healthcare management, while satisfying the growing demand for energy saving.
Triphenylamine‐Based Conjugated Microporous Polymers as the Next Generation Organic Cathode Materials
Authors: Amin Kamran , Baker Benjamin C. , Pan Long , Mehmood Warisha , Hao Zhang , Nawaz Raziq , Wei Zhixiang , Faul Charl F. J. 
Published: December 2024

AbstractThis paper presents a study on a novel porous polymer based on triphenylamine (LPCMP) as an excellent cathode material for lithium‐ion batteries. Through structural design and a scalable post‐synthesis approach, improvements in intrinsic conductivity, practical capacity, and redox potential in an organic cathode material is reported. The designed cathode achieves a notable capacity of 146 mAh g⁻¹ with an average potential of 3.6 V, using 70% active material content in the electrode. Additionally, through appropriate structural design, the capacity can increase to 160 mAh g−1. Even at a high current density of 20 A g⁻¹ (360C), the cathode maintains a capacity of 74 mAh g⁻¹, enabling full charge within 10 s. A high specific energy density of 569 Wh kg⁻¹ (at 0.1 A g⁻¹) is combined with a very high power density of 94.5 kW kg⁻¹ (at 20 A g⁻¹ corresponding to a specific energy density of 263 Wh kg⁻¹) surpassing the power density of graphene‐based supercapacitors. It exhibits highly stable cyclic performance across various current densities, retaining almost 95% of its initial capacity after 1000 cycles at 5.5C. This work presents a significant breakthrough in developing high‐capacity, high‐potential organic materials for sustainable, high‐energy, and high‐power lithium‐ion batteries.
A Metal–Polyphenol‐Based Antidepressant for Alleviating Colitis‐Associated Mental Disorders
Authors: Wang Zihao , Wang Zi‐Xi , Xu Ke‐Fei , An Yaolong , Cui Macheng , Zhang Xinping , Tian Linan , Li Chengcheng , Wu Fu‐Gen 
Published: December 2024

AbstractEmerging evidence suggests that patients with inflammatory bowel diseases (IBDs) are predisposed to psychosocial disturbances, such as depression and anxiety. Regrettably, clinical antidepressants exhibit unsatisfactory therapeutic efficacy in IBD‐associated psychosocial disturbances, primarily attributed to the inherent intestinal disorders and intricate bidirectional relationship between the gut and the brain. Herein, we report a metal–polyphenol‐based antidepressant to alleviate mental disorders in dextran sulfate sodium‐induced experimental acute colitis mice via modulating the microbiota–gut–brain axis. The antidepressant, termed CSMTC, comprises a core of melittin‐encapsulated natural antioxidant enzymes (i.e., catalase and superoxide dismutase) and a protective shell composed of tannic acid–cerium ion network. Upon oral administration to colitis mice, CSMTC can effectively restore colonic redox balance, reinforce the intestinal barrier, modulate gut microbiota composition, maintain the blood–brain barrier integrity, and regulate systemic immune responses. Notably, behavioral test results reveal that CSMTC significantly alleviates the colitis‐associated mental disorder (e.g., depression‐like behavior) via the microbiota–gut–brain axis by reducing neuroinflammation, enhancing hippocampal neural plasticity, modulating hippocampal immune responses, and restoring neurotransmitter homeostasis. This work may have implications for the development of new nanodrugs for treating inflammation‐associated complications.
Solution‐Processable Metal‐Organic Framework Featuring Highly Tunable Dynamic Aggregation States
Authors: Geng Lin , Qiao Yang , Sun Rui , Guo Linshuo , Li Ze‐Qi , Ma Yanhang , Yu Mei‐Hui , Chang Ze , Bu Xian‐He 
Published: December 2024

AbstractThe limited processability of metal‐organic frameworks (MOFs) is hindered flexibility in the manipulation of their aggregation state and applications. Therefore, achieving highly processable MOFs is of great significance but a challenging goal. Herein, a facile strategy is presented for achieving the construction of solution‐processable Mg‐based MOF, NKU‐Mg‐1, allowing for dynamic control of the aggregation state through dynamic self‐assembly (DySA) process and reversible circularly polarized luminescence (CPL) switcher modulation. Notably, micron‐sized crystals of NKU‐Mg‐1 can be readily dispersed in water to form nano‐sized colloids, triggered by the dynamic COO‐Mg coordination bonding interruption by the competitive H2O‐Mg bonding. Accordingly, the aggregation state of the colloid MOF can be readily tuned from 50–80 nm up to 1000 nm, in turn enabling control of aggregation‐dependent emission. Specially, the solid‐phase aggregation can be controlled via structural transitions between 3D NKU‐Mg‐1‐rec‐1 and 2D NKU‐Mg‐1‐rec‐2 nano‐crystals, as confirmed by 3D electron diffraction. Furthermore, benefiting from its highly dynamic tunable aggregation nature, the rational incorporation of the chiral module confers significant CPL activity (glum up to 0.01). Importantly, controllable dynamic aggregation enables reversible switching of the CPL activity by precisely regulating the aggregation states. The solution‐processable and dynamic aggregation‐tunable features endow it highly promising for applications.
Superconductivity up to 14.2 K in MnB4 Under Pressure
Authors: Xiang Zhe‐Ning , Zhang Ying‐Jie , Lu Qing , Li Qing , Li Yiwen , Huang Tianheng , Zhu Yijie , Ye Yongze , Sun Jian , Wen Hai‐Hu 
Published: December 2024

AbstractThe discovery of superconductivity in 3d transition‐metal compounds with strong magnetism is interesting but rare. Especially for Mn‐based compounds, there exist only very limited materials that show superconductivity. Here, the discovery of superconductivity is reported with an onset transition temperature up to 14.2 K in a Mn‐based material MnB4, which is the highest value among the stoichiometric Mn‐based superconductors. By applying high pressure, the continuous suppression of a weak semiconducting behavior and the occurrence of superconductivity after ≈30 GPa are found. With further increasing pressure, the superconducting transition temperature (Tc) is gradually enhanced and reaches the maximum onset transition value of ≈14.2 K at 150 GPa. The synchrotron X‐ray diffraction data reveal the unchanged monoclinic (S.G: P21/c) symmetry but an unusual crossover of the lattice parameters b and c in a certain pressure region as confirmed by the theoretical calculation. The findings show a promising way to explore high Tc superconductivity by combining the 3d‐transition metal magnetic elements and light elements.
Electrochemically Driven Site‐Selective C(sp2)−H Bond Hydroxylation of N‐Substituted Anilines
Authors: Dapkekar Anil Balajirao , Nag Suman Kumar , Satyanarayana Gedu 
Published: December 2024

AbstractOrganic synthesis has long been fascinated by phenolic compounds, especially their exploration of selectively hydroxylating arenes utilizing H2O as a hydroxyl source. However, phenols′ low redox potential and strong reactivity frequently result in unwanted overoxidation byproducts. Here, we present an electrochemical strategy to overcome this difficulty by using electricity as an oxidant and facilitating the para‐selective hydroxylation of N‐protected anilines. This process exhibits excellent regio‐selectivity, compatibility with diverse functional groups, and adaptability by handling an extensive range of substrates. Noteworthily, the technique provides a sustainable substitute for paracetamol synthesis and terminal acetylene‐holding hydroxylated products, proving the suitability of this strategy for drug synthesis. Significantly, mechanistic investigations suggest the possible radical pathway and water as a hydroxyl source for this strategy.
A Review of Studies on the Breeding, Reproduction and Fry Rearing of Largemouth Bass (Micropterus nigricans) in China
Authors: Wang Shoubing , Song Zijie , Liu Xingguo , Xu Sihan , Gu Zhaojun 
Published: December 2024

ABSTRACTMany countries and regions around the world have been adversely affected by the invasive spread of the largemouth bass (Micropterus nigricans). The breeding practices developed in China can serve as a reference for these regions to manage this species scientifically while providing high‐quality protein for human consumption. As its introduction from Taiwan in 1983, the largemouth bass has become one of the most significant high‐quality freshwater farmed fish in mainland China. The country has developed new varieties that exhibit faster growth rates and enhanced adaptability to artificial compound feed, leading to widespread aquaculture across the nation. This article systematically reviews the technological advancements in the introduction, breeding, reproduction and rearing of fry and fingerlings of largemouth bass in China over the last 40 years. After summarizing the progress in general breeding as well as fry and fingerling rearing technologies, we analyse three successful early breeding and out‐of‐season breeding modes developed in China. The advancement of innovative and practical breeding and seedling technologies has addressed the challenges of natural breeding in regions with relatively low temperatures, where it is not feasible to raise local fry to a marketable size for consumption within the same year. This progress significantly enhances largemouth bass aquaculture in China.
Plasma p‐tau immunoassays in clinical research for Alzheimer's disease
Authors: Teunissen Charlotte E. , Kolster Rachel , Triana‐Baltzer Gallen , Janelidze Shorena , Zetterberg Henrik , Kolb Hartmuth C. 
Published: December 2024

AbstractThe revised biomarker framework for diagnosis and staging of Alzheimer's disease (AD) relies on amyloid beta (Aβ) and tau pathologies as core markers, and markers for adjacent pathophysiology, such as neurodegeneration and inflammation. Many of the core fluid biomarkers are phosphorylated tau (p‐tau) fragments, with p‐tau217 showing a prominent association with Aβ and tau. While positron emission tomography (PET) imaging is well established, plasma p‐tau assays are newer and likely to reduce the use of expensive, and less accessible cerebrospinal fluid and PET imaging tests, thereby promoting wider access to AD screening. There is a need for greater understanding of how the various plasma p‐tau species reflect different pathological processes of AD and how different immunoassays perform. This review surveys the available immunoassays and highlights their strengths and limitations in different contexts of use. Assays need to be standardized to maximize their impact on AD clinical research, and patient diagnosis and management.Highlights
Different plasma phosphorylated tau (p‐tau) species reflect different pathological processes of Alzheimer's disease (AD), with p‐tau231 showing the greatest association with the earliest increases in brain amyloid beta (Aβ) accumulation, while p‐tau217 shows greater association with both brain Aβ and early tau pathology, and other p‐tau and tau fragment species show greater association with later stages of brain tau pathology.
Plasma p‐tau217 has proven to be an excellent biomarker for AD pathology due to its close association with both brain Aβ and tau pathology, as well as its large dynamic range.
Many different assays with varying performance exist for the same p‐tau species, with mass spectrometry assays performing uniformly well, and several immunoassays achieving comparable performance.
“Round robin” head‐to‐head studies have been performed to compare different assays for several key plasma biomarkers, including p‐tau181 and p‐tau217, but additional head‐to‐head studies are needed, especially for new analytes and for measuring performance in diverse populations.
Plasma immunoassays have the potential to increase accessibility of early diagnostic testing for a broad population, including diverse historically under‐represented and under‐served populations, due to the potential to be implemented globally, including in primary care settings; however, further research is needed to validate the optimal cutoffs for each assay for real‐world clinical usage.
Eventually, clinical implementation of a two‐step workflow may allow standalone use of plasma testing in certain contexts, minimizing the need for confirmation with costly and less accessible cerebrospinal fluid/positron emission tomography testing.