bluuebunny/crossref_metadata_2025_split huggingface dataset:
Training Non-Native Consonant Production with Perceptual and Articulatory Cues
Authors: Cibelli Emily 
Published: March 2019

Abstract

Background/Aims:
Adult learners often struggle to produce novel phonemes in a second language and lack clear articulatory targets. This study investigates the combined efficacy of perceptual and articulatory training, the latter involving explicit instruction about tongue position and laryngeal control, for the production of non-native phonemes.
Methods:
Native English speakers were trained on a series of Hindi coronal stop consonants, with production assessed before, during, and after training sessions, on the basis of acoustic cues to place of articulation and voicing.
Results:
Improvement in production was most apparent during artic u­latory training, when cues to target articulation were available to learners. Some improvements were maintained after training was concluded.
Conclusion:
Articu­latory training can contribute useful cues to pronunciation for early learners. Improvement in acquisition of targets varies in stability across learners and targets.
The identity of catfishes identified as Mystus cavasius (Hamilton, 1822) (Teleostei: Bagridae), with a description of a new species from Myanmar
Authors: CHAKRABARTY PROSANTA , NG HEOK HEE 
Published: March 2019

The identity of South Asian riverine bagrid catfishes usually referred to as Mystus cavasius (Hamilton, 1822) is reviewed. Three species comprise what is currently understood as M. cavasius: M. cavasius s. str. from northern India, M. seengtee from southern India and a new species, M. falcarius, from the Salween and Irrawaddy river drainages in Myanmar and the shorter river drainages in southern Myanmar. Mystus seengtee is resurrected from synonymy with M. cavasius and both species are redescribed. The three species differ from other congeners with a long-based adipose fin in having a combination of a black spot in front of the dorsal-spine base, a dark humeral mark, a body without distinct midlateral stripes, very long maxillary barbels reaching to caudal-fin base, dorsal spine short and feebly serrate, tall dorsal fin, and 13ñ29 gill rakers. These species differ from each other in dorsal fin shape, shape of the predorsal profile, coloration, and number of rakers on the first gill arch.
Notes on Burmese spiders formerly attributed to the genus Storena (Zodariidae, Araneae) PAKAWIN DANKITTIPAKUL (Thailand), MARIA TAVANO (Italy) &amp; TIPPAWAN SINGTRIPO (Thailand)
Authors: DANKITTIPAKUL PAKAWIN , TAVANO MARIA , SINGTRIPOP TIPPAWAN 
Published: March 2019

Studies on the spider fauna of Southeast Asia resulted in a review of five Storena species which were previously described from Burma. These species were misplaced in Storena Walckenaer, 1805, a zodariid genus that is endemic to Australia. Four species are here transferred to Mallinella Strand, 1906: Mallinella suavis (Thorell, 1895) comb. nov., M. exornata (Thorell, 1887) comb. nov., M. fronto (Thorell, 1887) comb. nov., and M. decorata (Thorell, 1885) comb. nov. Mallinella irrorata (Thorell, 1887) belongs to an undescribed genus of the subfamily Zodariinae. This study also gives a complete list of all Storena specimens examined and studied by Thorell which are now deposited in four European museums.
Sahel Rainfall–Tropical Easterly Jet Relationship on Synoptic to Intraseasonal Time Scales
Authors: Lemburg Alexander , Bader Jürgen , Claussen Martin 
Published: March 2019

Abstract
The tropical easterly jet (TEJ) is a characteristic upper-level feature of the West African monsoon (WAM) circulation. Moreover, the TEJ over West Africa is significantly correlated with summer Sahel rainfall on interannual and decadal time scales. In contrast, the relationship between Sahel rainfall and the regional TEJ on synoptic to intraseasonal time scales is unclear. Therefore, this relationship is investigated by means of multiple statistical analyses using temporally highly resolved measurement and reanalysis data. It is shown that average correlations between convective activity and regional TEJ intensity remain below 0.3 for all synoptic to intraseasonal time scales. Especially on the synoptic time scale, the TEJ significantly lags anomalies in convective activity by one or two days, which indicates that convection anomalies are more likely to drive changes in the regional TEJ than vice versa. To further shed light on the role of the TEJ for rainfall over West Africa, a previously proposed effect of TEJ-induced upper-level divergence on the development of mesoscale convective systems (MCSs) is examined more closely. An analysis of nearly 300 Sahelian MCSs shows that their initiation is generally not associated with significant TEJ anomalies or jet-induced upper-level divergence. Furthermore, no statistically significant evidence is found that preexisting TEJ-related upper-level divergence anomalies affect intensity, size, and lifetime of MCSs. A limiting factor of this study is the focus on TEJ-induced upper-level divergence. Therefore, a possible effect of the TEJ on Sahel rainfall via other mechanisms cannot be ruled out and should be subject to future studies.
Comparison of Transmastoid and Middle Fossa Approaches for Superior Canal Dehiscence Repair: A Multi‐institutional Study
Authors: Schwartz Seth R. , Almosnino Galit , Noonan Kathryn Y. , Banakis Hartl Renee M. , Zeitler Daniel M. , Saunders James E. , Cass Stephen P. 
Published: March 2019

ObjectiveTo compare outcomes for patients undergoing a transmastoid approach versus a middle fossa craniotomy approach with plugging and/or resurfacing for repair of superior semicircular canal dehiscence. Outcome measures include symptom resolution, hearing, operative time, hospital stay, complications, and revision rates.Study DesignMulticenter retrospective comparative cohort study.SettingsThree tertiary neurotology centers.Subjects and MethodsAll adult patients undergoing repair for superior canal dehiscence between 2006 and 2017 at 3 neurotology centers were included. Demographics and otologic history collected by chart review. Imaging, audiometric data, and vestibular evoked myogenic potential measurements were also collected for analysis.ResultsA total of 68 patients (74 ears) were included in the study. Twenty‐one patients underwent middle fossa craniotomy repair (mean age, 47.9 years), and 47 underwent transmastoid repair (mean age, 48.0 years). There were no significant differences in age or sex distribution between the groups. The transmastoid group experienced a significantly shorter duration of hospitalization and lower recurrence rate as compared with the middle fossa craniotomy group (3.8% vs 33%). Both groups experienced improvement in noise‐induced vertigo, autophony, pulsatile tinnitus, and nonspecific vertigo. There was no significant difference among symptom resolution between groups. Additionally, there was no significant difference in audiometric outcomes between the groups.ConclusionBoth the transmastoid approach and the middle fossa craniotomy approach for repair of superior canal dehiscence offer symptom resolution with minimal risk. The transmastoid approach was associated with shorter hospital stays and lower recurrence rate as compared with the middle fossa craniotomy approach.
Tumor-educated platelets
Authors: In ‘t Veld Sjors G. J. G. , Wurdinger Thomas 
Published: March 2019

AbstractLiquid biopsies have been considered the holy grail in achieving effective cancer management, with blood tests offering a minimally invasive, safe, and sensitive alternative or complementary approach for tissue biopsies. Currently, blood-based liquid biopsy measurements focus on the evaluation of biomarker types, including circulating tumor DNA, circulating tumor cells, extracellular vesicles (exosomes and oncosomes), and tumor-educated platelets (TEPs). Despite the potential of individual techniques, each has its own advantages and disadvantages. Here, we provide further insight into TEPs.
Full high-throughput sequencing analysis of differences in expression profiles of long noncoding RNAs and their mechanisms of action in systemic lupus erythematosus
Authors: Ye Hui , Wang Xue , Wang Lei , Chu Xiaoying , Hu Xuanxuan , Sun Li , Jiang Minghua , Wang Hong , Wang Zihan , Zhao Han , Yang Xinyu , Wang Jianguang 
Published: March 2019

Abstract
Background
The specific function of long noncoding RNAs (lncRNAs) in systemic lupus erythematosus (SLE) and the mechanism of their involvement in related pathological changes remain to be elucidated, so, in this study, we analyzed the differences in the expression profiles of lncRNAs and their mechanisms of action in SLE using full high-throughput sequencing, bioinformatics, etc. methods.

Methods
We used high-throughput sequencing to detect differences in the expression profiles of lncRNAs, miRNAs, and mRNAs in PBMCs from patients with SLE at the genome-wide level. Next, we predicted target genes of 30 lincRNAs (long intergenic noncoding RNAs) by constructing a coexpression network of differential lincRNAs and mRNAs and identified the role of lincRNAs. Then, we analyzed the coexpression network of 23 optimized lincRNAs and their corresponding 353 miRNAs, evaluated the cis- and trans-effects of these lincRNAs, and performed GO and KEGG analyses of target genes. We also selected 8 lincRNAs and 2 newly discovered lncRNAs for q-PCR validation and lncRNA–miRNA–mRNA analysis. Finally, we also analyzed respectively the relation between lncRNAs and gender bias in SLE patients using RT-qPCR, the relation between Systemic Lupus Erythematosus Disease Activity Index score and the “IFN signature” using ELISA, and the relation between the differential expression of lncRNAs and a change in the number of a cell type of PBMCs in SLE patients using RT-qPCR.

Results
The profiles of 1087 lncRNAs, 102 miRNAs, and 4101 mRNAs in PBMCs significantly differed between patients with SLE and healthy controls. The coexpression network analysis showed that the network contained 23 lincRNAs and 353 mRNAs. The evaluation of the cis- and trans-effects showed that the 23 lincRNAs acted on 704 target genes. GO and KEGG analyses of the target genes predicted the biological functions of the 23 lincRNAs. q-PCR validation showed 7 lincRNAs and 2 novel lncRNAs were identical to the sequencing results. The ceRNA network contained 7 validated lincRNAs, 15 miRNAs, and 155 mRNAs. In addition, the differential expression of lncRNAs may be gender dependent in SLE patients, SLE patients also exhibit a robust “IFN signature,” and PBMCs exhibiting differential expression of lncRNAs may be due to a change in the number of a cell type.

Conclusion
This work determined specific lncRNAs that play important biological functions in the pathogenesis of lupus and provided a new direction for diagnosis and treatment of disease.
Drosophila Ptp4E regulates vesicular packaging for monoamine-neuropeptide co-transmission
Authors: Tao Juan , Bulgari Dinara , Berkhoudt Drew A. , Calderon Michael J. , Watkins Simon C. , Fonseca Velez Hector J. , Sabeva Nadezhda , Deitcher David L. , Levitan Edwin S. 
Published: March 2019

ABSTRACT
Many neurons influence their targets through co-release of neuropeptides and small-molecule transmitters. Neuropeptides are packaged into dense-core vesicles (DCVs) in the soma and then transported to synapses, while small-molecule transmitters such as monoamines are packaged by vesicular transporters that function at synapses. These separate packaging mechanisms point to activity, by inducing co-release as the sole scaler of co-transmission. Based on screening in Drosophila for increased presynaptic neuropeptides, the receptor protein tyrosine phosphatase (Rptp) Ptp4E was found to post-transcriptionally regulate neuropeptide content in single DCVs at octopamine synapses. This occurs without changing neuropeptide release efficiency, transport and DCV size measured by both stimulated emission depletion super-resolution and transmission electron microscopy. Ptp4E also controls the presynaptic abundance and activity of the vesicular monoamine transporter (VMAT), which packages monoamine transmitters for synaptic release. Thus, rather than rely on altering electrical activity, the Rptp regulates packaging underlying monoamine-neuropeptide co-transmission by controlling vesicular membrane transporter and luminal neuropeptide content.
This article has an associated First Person interview with the first author of the paper.
Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt
Authors: Gleason Catherine E. , Oses-Prieto Juan A. , Li Kathy H. , Saha Bidisha , Situ Gavin , Burlingame Alma L. , Pearce David 
Published: March 2019

ABSTRACT
mTORC2 lies at the intersection of signaling pathways that control metabolism and ion transport through phosphorylation of the AGC-family kinases, the Akt and SGK1 proteins. How mTORC2 targets these functionally distinct downstream effectors in a context-specific manner is not known. Here, we show that the salt- and blood pressure-regulatory hormone, angiotensin II (AngII) stimulates selective mTORC2-dependent phosphorylation of SGK1 (S422) but not Akt (S473 and equivalent sites). Conventional PKC (cPKC), a critical mediator of the angiotensin type I receptor (AT1R, also known as AGTR1) signaling, regulates the subcellular localization of SIN1 (also known as MAPKAP1) and SGK1. Inhibition of cPKC catalytic activity disturbs SIN1 and SGK1 subcellular localization, re-localizing them from the nucleus and a perinuclear compartment to the plasma membrane in advance of hormonal stimulation. Surprisingly, pre-targeting of SIN1 and SGK1 to the plasma membrane prevents SGK1 S422 but not Akt S473 phosphorylation. Additionally, we identify three sites on SIN1 (S128, S315 and S356) that are phosphorylated in response to cPKC activation. Collectively, these data demonstrate that SGK1 activation occurs at a distinct subcellular compartment from that of Akt and suggests a mechanism for the selective activation of these functionally distinct mTORC2 targets through subcellular partitioning of mTORC2 activity.
Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling
Authors: Rahikainen Rolle , Öhman Tiina , Turkki Paula , Varjosalo Markku , Hytönen Vesa P. 
Published: March 2019

ABSTRACT
Talin protein is one of the key components in integrin-mediated adhesion complexes. Talins transmit mechanical forces between β-integrin and actin, and regulate adhesion complex composition and signaling through the force-regulated unfolding of talin rod domain. Using modified talin proteins, we demonstrate that these functions contribute to different cellular processes and can be dissected. The transmission of mechanical forces regulates adhesion complex composition and phosphotyrosine signaling even in the absence of the mechanically regulated talin rod subdomains. However, the presence of the rod subdomains and their mechanical activation are required for the reinforcement of the adhesion complex, cell polarization and migration. Talin rod domain unfolding was also found to be essential for the generation of cellular signaling anisotropy, since both insufficient and excess activity of the rod domain severely inhibited cell polarization. Utilizing proteomics tools, we identified adhesome components that are recruited and activated either in a talin rod-dependent manner or independently of the rod subdomains. This study clarifies the division of roles between the force-regulated unfolding of a talin protein (talin 1) and its function as a physical linker between integrins and the cytoskeleton.
Paralelización del corpus sensem: español-catalán
Authors: Vázquez García Gloria , Fernández Montraveta Ana 
Published: March 2019

En ese trabajo presentamos un corpus paralelo para las lenguas española y catalana, SenSem. Se trata de un corpus paralelo anotado a distintos niveles lingüísticos (morfológico, sintáctico y semántico) y que abarca distintas unidades de información (palabra, sintagma y oración). Uno de los valores principales de este recurso es que ha supuesto la creación del primer corpus del catalán con información relativa a aspectos de la semántica oracional, como la aspectualidad y la modalidad. El recurso se ha creado traduciendo al catalán el corpus ya creado para el español en un proyecto anterior y manteniendo los vínculos entre ambas lenguas entre las distintas unidades de información mencionadas. Además, se ha heredado la anotación que se llevó a cabo para el español, corrigiendo cuando ha sido necesario la información para el catalán.
Les competències professionals dels titulats universitàris d'ADE: valoració de les necessitats formatives
Authors: Bartual Figueras M. Teresa , Adillon Boladeres Roman Jordi , Garcia Marimón Xavier , Simó i Solsona Montserrat , Turmo-Garuz Joaquin 
Published: March 2019

El principal objectiu d'aquest treball és identificar la demanda de competències professionals dels titulats d'ADE i el desajust entre les competències adquirides pels titulats, és a dir l'oferta, i la demanda de competències per part dels ocupadors. L'estudi es basa en l'opinió dels empresaris, obtinguda a través d'una enquesta i d’entrevistes en profunditat. Els resultats mostren que les empreses valoren les competències genèriques més que les específiques i que, al mercat de treball, el desenvolupament de les competències transversals és un element determinant de l'ocupabilitat. Els resultats plantegen la necessitat de reorientar la formació i els mètodes d’ensenyament-aprenentatge i suggereixen la conveniència d'una relació més profunda entre les universitats i les empreses.
592. Geografías de la contención: el rol de las políticas de escala barrial en el Chile neoliberal
Authors: Tapia Barría Verónica 
Published: March 2019

Las políticas de escala barrial adquieren protagonismo a partir de la década de los noventa, al término de la dictadura cívico-militar de Augusto Pinochet y el inicio de los gobiernos democráticos, vinculadas al panorama político ideológico del país post dictadura y la reestructuración global capitalista de carácter neoliberal. En este contexto, las políticas de escala barrial se entienden como tecnologías de disciplinamiento para regular, desplazar, controlar y delimitar los conflictos derivados de la implementación de políticas urbanas neoliberales, evidenciados en la persistente pobreza y desigualdades urbanas. A partir de un recorrido por la noción de barrio como escala de intervención y el análisis específico del caso chileno el artículo propone la figura de la contención –en tanto consuelo, contenedor y control- para entender el rol de las políticas de escala barrial.
A Case of Severe, Nilotinib-Induced Liver Injury
Authors: Belopolsky Yuliya , Grinblatt David L. , Dunnenberger Henry M. , Sabatini Linda M. , Joseph Nora E. , Fimmel Claus J. 
Published: March 2019

Abstract
Idiosyncratic hepatotoxicity is a leading reason for the discontinuation or dose modification of Food and Drug Administration (FDA)-approved medications in the United States. We report the case of a 53-year-old woman with chronic myeloid leukemia who developed acute cholestatic hepatitis in response to the tyrosine kinase inhibitor nilotinib. Nilotinib was discontinued, and the patient's liver function tests normalized over the next 3 months. We conclude that nilotinib may cause life-threatening hepatotoxicity and recommend that patients on the medication undergo regular monitoring of their liver tests.
Gastric Solitary Fibrous Tumor Causing Upper Gastrointestinal Bleeding
Authors: Kimmel Jessica , Dikman Andrew , Hajdu Cristina 
Published: March 2019

Abstract
We present an 81-year-old woman with remote breast cancer who presented with melena and hemorrhagic shock requiring intensive care hospitalization. Endoscopic evaluation showed a 5-cm pedunculated gastric mass with ulceration and friability. She underwent sleeve gastrectomy for definitive treatment of her bleeding. Pathology was consistent with a solitary fibrous tumor (SFT). There are only a few reported cases of gastric SFTs presenting with gastrointestinal bleeding. If a large brown/tan bleeding mass is identified on upper endoscopy, SFT should be considered.
Voriconazole-Induced Hepatotoxicity Presenting With Severe Hepatic Encephalopathy After Liver Transplantation
Authors: Tasleem Syed Haris , Cappell Mitchell S. 
Published: March 2019

Abstract
Voriconazole-induced hepatotoxicity is a relatively rare but serious clinicopathologic entity. This drug is frequently used for invasive aspergillosis and other fungal infections. We report a patient with alcoholic cirrhosis who developed hepatic encephalopathy due to voriconazole administered for invasive pulmonary aspergillosis and subsequently showed marked improvement in mental status with dose adjustment of the drug. The patient eventually underwent an uneventful liver transplant. Histopathologic examination of the diseased liver specimen revealed numerous rhomboid-shaped crystals, deemed secondary to liver injury after voriconazole-induced hepatotoxicity. Additionally, this article briefly reviews the available data on voriconazole-induced hepatotoxicity with special emphasis on plasma drug concentration monitoring.
Organic Unities
Authors: Floyd Graham 
Published: March 2019

The principle of organic unities is a metaphysical claim regarding the nature of moral value. It states that the value of the whole is not equal to the summation of its parts. Even though this principle has a major impact on moral theory, it has been neglected in the consideration of the problem of God and evil. I claim that the theist can utilize the principle of organic unities to undermine the problem of evil. First, I explain the principle of organic unities and how it affects one’s understanding of moral value. Next, I explicate the two major historical versions of the problem of evil: the logical argument from evil and the evidential argument from evil. Lastly, I argue that the principle of organic unities demonstrates that God may logically co-exist with evil and that the atheologian lacks rational warrant appealing to gratuitous evil against God’s existence. As a result, both problems fail.
Analysis of Slope Creep in the Example of a Landslide Slope in Koronowo near Bydgoszcz
Authors: Zabuski Lesław 
Published: March 2019

Abstract
This paper presents the results of a numerical simulation of a slope deformation process. The landslide slope “Grabina” in Koronowo near Bydgoszcz (Poland) serves as an example. A slope profile located in the central part of the slope, between the main scarp and the toe of the landslide, was selected. The average dip of the slope is about 10, and its length is approximately 55 m.
Elasticity, plasticity and viscosity properties were taken into account in the model of the soil mass that composes the slope. The visco-elastic properties are described by the Burgers model (Mainardi and Spada 2011), and the plastic ones by the Coulomb-Mohr law. A numerical simulation was carried out by the computer code FLAC2D in the plane strain state with the assumption of the Lagrange routine. The model was discretized taking into account the results of inclinometric measurements, which proved that the slide movement was concentrated in a narrow loam zone of 0.5–1.0 m thickness.
No tests of the viscosity parameters were performed, so they were determined by the back analysis and a trial and error method. The calculation results were verified by comparison with the displacement measured by the inclinometric method in three boreholes. The analysis performed demonstrated the possibility of approximating and forecasting landslide displacements by the combined Burgers and Coulomb-Mohr models.