bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the function of MAGE-A in esophageal carcinoma by bioinformatics
Authors: Chen Xiaohua , Cai Sina , Wang Liping , Zhang Xiaona , Li Wenhui , Cao Xiaolong 
Published: May 2019

Abstract

Background:
Melanoma-associated antigen-A (MAGE-A) was recognized as high-expressed in many solid tumors including esophageal carcinoma (EC), nevertheless, was reported to be low/not-expressed in normal tissues. Thus, it was considered as an extraordinary appropriate target for treatment especially in immunotherapy. Therefore, it demanded more detail knowledge on the precise function of MAGE-A.

Methods:
In this study, we used the data from the Cancer Genome Atlas dataset (TCGA-ESCA) to analyze the expression and survival for MAGE A3/4/11 (the subtype of MAGE-A) using the online tool of UALCAN. Furthermore, the high-throughput sequencing data of the patients with esophageal squamous-cell carcinoma (ESCC) from TCGA dataset were performed to analyze the correlation test, gene ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment of MAGE A3/4/9/11 using LinkeDomics (online tool) and ClueGO (inner software of Cytoscape). Finally, relative gene expressions of MAGE A3/4/9/11 were verified by quantitative real-time PCR (q-PCR) in the patients with EC.

Results:
MAGE A3/4/11 was high-expressed in tissues of patients with ESCC, and there was no difference in survival time for patients between the high-expressed with the low/medium-expressed. The Go enrichment analysis showed that the 4 MAGE-A subtypes (MAGE-A3/4/9/11) were enriched in the regulation of the adaptive immune response, translational initiation, interleukin-4 production, response to type I interferon, and skin development, respectively. The KEGG results showed that they were enriched in T cell receptor signaling pathway (MAGE-A3), Th1 and Th2 differentiation, antigen processing and presentation (MAGE-A4), cytokine-cytokine receptor interaction (MAGE-A9), and chemokine signaling pathway (MAGE-A11).

Conclusion:
MAGE A3/4/9/11 was high-expressed in EC, and were enrolled in the regulation of immune response. They may consider as candidate immune target for EC treatment and provided the messages for further research in the function of MAGE-A.
Development of model to predict end-stage renal disease after coronary artery bypass grafting
Authors: Lee Yeonhee , Park Jiwon , Jang Myoung-Jin , Moon Hong Ran , Kim Dong Ki , Oh Kook-Hwan , Joo Kwon Wook , Lim Chun Soo , Kim Yon Su , Na Ki Young , Han Seung Seok 
Published: May 2019

Abstract
Because end-stage renal disease (ESRD) increases the risks of morbidity and mortality, early detection and prevention of ESRD is a critical issue in clinical practice. However, no ESRD-prediction models have been developed or validated in patients undergoing coronary artery bypass grafting (CABG).
This is a retrospective multicenter cohort study, recruited between January 2004 and December 2015. A cohort of 3089 patients undergoing CABG in two tertiary referral centers was analyzed to derive a risk-prediction model. The model was developed using Cox proportional hazard analyses, and its performance was assessed using C-statistics. The model was externally validated in an independent cohort of 279 patients.
During the median follow-up of 6 years (maximum 13 years), ESRD occurred in 60 patients (2.0%). Through stepwise selection multivariate analyses, the following three variables were finally included in the ESRD-prediction model: postoperative Acute kidney injury, underlying Chronic kidney disease, and the number of antiHypertensive drugs (ACHE score). This model showed good performance in predicting ESRD with the following C-statistics: 0.89 (95% confidence interval [CI] 0.84–0.94) in the development cohort and 0.82 (95% CI 0.60–1.00) in the external validation cohort.
The present ESRD-prediction model may be applicable to patients undergoing CABG, with the advantage of simplicity and preciseness.
Prognostic value of long non-coding RNA breast cancer anti-estrogen resistance 4 in human cancers
Authors: Meng Yang , Liu Yu-Lan , Li Kai , Fu Tao 
Published: May 2019

Abstract

Background:
Since long non-coding RNA breast cancer anti-estrogen resistance 4 (lncRNA BCAR4) is dysregulated in various types of cancers, we conducted a meta-analysis to determine its prognostic value in cancer.

Methods:
PubMed, EMBASE database, and CENTRAL were systematically searched.
Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were collected to estimate the prognostic value. Odds ratios (ORs) and their 95% CIs were used to assess the association between lncRNA BCAR4 expression and clinicopathological features, including tumor size, differentiation, lymph node metastasis, distant metastasis, and tumor stage.

Results:
Ten studies with 890 patients were included in this meta-analysis. The pooled results indicated that high lncRNA BCAR4 expression was associated with poor overall survival (OS) (HR 2.80, 95% CI: 2.08–3.78; P < .001). Overexpression of lncRNA BCAR4 was related to lymph node metastasis (OR 3.68, 95% CI: 2.25–6.00; P < .001), high tumor stage (OR 3.19, 95% CI: 1.98–5.13; P < .001), and distant metastasis (OR 3.83, 95% CI: 2.15–6.82; P < .001), but not to tumor size.

Conclusions:
Therefore, lncRNA BCAR4 overexpression is associated with poor OS and advanced clinicopathological features, and lncRNA BCAR4 may be a novel prognostic biomarker in cancer patients. However, further high-quality studies are needed to confirm these findings.
Total laparoscopic duodenum-preserving pancreatic head resection for solid pseudopaillary neoplasm of pancreas
Authors: Liang Bin , Chen Yuanyuan , Li Mengyang , Dong Xiaofeng , Yao Siyang , Liu Tianqi 
Published: May 2019

Abstract

Rationale:
There is controversy regarding the optimal surgical approach for pancreatic lesions in the head of the pancreas. Duodenum-preserving pancreatic head resection compared with pancreaticoduodenectomy is technically more challenging, but preserves more functional pancreatic tissue.

Patient concerns:
A 25-year-old woman was admitted to our department on May 10, 2017. Computed tomographic's saw a 2.0 × 2.1-cm lesion located in the head of pancreas and its diagnosis was nonfunctional neuroendocrine tumors? The magnetic resonance cholangiopancreatography scan demonstrated a solitary 1.6 × 1.7-cm lesion located in the head of pancreas, and its diagnosis was tumor. The patient's condition was good and symptomless, without any disease history. Physical examination and routine blood investigations were normal. All pancreatic malignant tumor biological markers were negative.

Diagnoses:
Solid pseudopapillary neoplasm of pancreas.

Interventions:
Total laparoscopic head pancreatectomy with Roux-Y pancreaticojejunostomy was performed.

Outcomes:
The recovery was smooth after surgery. At the end of 20 months follow-up, she was well and showed no signs of recurrence.

Lessons:
The anatomy of the operation is clearer and easier than open surgery because of the magnification effect of laparoscopy. Total laparoscopic head pancreatectomy is safe, effective, and feasible for solid pseudopapillary neoplasm of pancreas, and it should be equally applicable to some other pancreatic cystic neoplasms and neuro-endocrine tumors.
Engaging Patients and Caregivers in Research for Pediatric Inflammatory Bowel Disease
Authors: Grant Amy , Crane Melissa , Laupacis Andreas , Griffiths Anne , Burnett Dave , Hood Amanda , Kluthe Cheryl , Maghera Muneet , Mann Malcolm , Mansi Melissa , Murray Kate , Trempe Marie‐Josée , Otley Anthony 
Published: May 2019

ABSTRACTIntroduction:Including individuals with lived experience in pediatric inflammatory bowel disease (IBD) is essential to establishing a research agenda that is mutually impactful to both those treating and those experiencing the disease.Methods:Using the James Lind Alliance approach to research priority setting, a 10‐member steering committee composed of current and former pediatric patients with IBD, caregivers, and clinicians was formed. A national survey, disseminated across Canada, elicited uncertainties which were divided into unanswered and answered research questions. Subsequently a research prioritization survey was disseminated where respondents ranked their top 20 research uncertainties. A final prioritization meeting was held to agree upon the top 10 uncertainties.Results:From 1209 research questions submitted by 363 participants, the list was reduced to 105 indicative questions that were within scope and deemed unanswered in the literature. Via the national research prioritization survey, this list was further reduced. The top 10 uncertainties identified at the final research consensus meeting, with 21 participants from all stakeholder groups, included “What are the causes of IBD?,” “Can IBD be prevented?,” “What role does diet have in the management of pediatric IBD?.” Other questions concerned flare ups, biomarkers, optimal patient education, long‐term effects of medication and early‐diagnosis, role of psychological support, and optimal approach to diagnosis.Conclusion:This research adds a unique perspective by deriving a list of pediatric IBD research uncertainties important by patients and caregivers and clinicians.
DYRK1A up-regulation specifically impairs a presynaptic form of long-term potentiation
Authors: Lepagnol-Bestel Aude-Marie , Haziza Simon , Viard Julia , Salin Paul A. , Crépel Valérie , Duchon Arnaud , Herault Yann , Simonneau Michel 
Published: May 2019

ABSTRACTChromosome 21 DYRK1A kinase has long been associated with a variety of psychiatric diseases including Down Syndrome. We previously showed that Dyrk1A interacts with SWI/SNF (SWItch/Sucrose Non-Fermentable) nucleosome remodeling complex inducing expression changes of genes encoding key neuronal proteins. However, the functional impact of this kinase at the synapse level remains unclear. We studied a mouse model that incorporated the YAC 152F7 (570 kb) encoding six chromosome 21 genes including DYRK1A. We found that DYRK1A Interacts with the key chromatin remodelers EP300 and CREBBP. Moreover, we observed changes in the transcriptional levels of genes encoding presynaptic proteins involved in glutamate vesicle exocytosis, namely Rims1, Munc13-1, Syn2, Rab3A. This result prompted us to investigate the two main forms of long-term potentiation (LTP) required for learning and memory: the (N-methyl d-aspartate) receptor-dependent postsynaptic form versus the glutamate release-dependent presynaptic form. Interestingly, extracellular electrophysiological recordings in hippocampal slices of the YAC mouse line revealed that only the presynaptic forms of plasticity were impacted, leaving the post-synaptic form of plasticity intact. T o refine our findings, we used a mouse BAC 189N3 (152 kb) line that only triplicate the gene Dyrk1A. Again, we found that this presynaptic form of LTP is also impaired in this mouse line. This result demonstrates that abnormal up-regulation of Dyrk1A alone is sufficient to inhibit specifically the presynaptic forms of LTP. Altogether, our results suggest that impairment of DYRK1A gene dosage may impact memory precision, and therefore reinforce our mechanistic understanding of the cognitive impairment detected in this mouse model.
Characterization of threeYarrowia lipolyticastrains in respect to different cultivation temperatures and metabolite secretion
Authors: Hackenschmidt S , Bracharz F , Daniel R , Thürmer A , Bruder S , Kabisch J 
Published: May 2019

AbstractDespite the increasing relevance, ranging from academic research to industrial applications, only a limited number of nonconventional, oleaginousYarrowia lipolyticastrains are characterized in detail. Therefore, we analyzed three strains in regard to their metabolic and physiological properties and in respect to important characteristics of a production strains. A flow cytometry method was set up to evaluate their fitness in a rapid manner. By investigating different cultivation conditions and media compositions, similarities and differences between the distinct strain backgrounds could be derived. Especially sugar alcohol production, as well as a agglomeration of cells were found to be connected with growth at high temperatures. In addition, sugar alcohol production was independent of high substrate concentrations under these conditions. To investigate particular traits, including growth characteristics and metabolite concentrations, genomic analysis were performed. We found sequence variations for one third of the annotated proteins but no obvious link to all phenotypic features.
Tone fitness ladies’ studio: market segmentation or market mix?
Authors: Al Zaidi Sameera Mohamed , Ahmad Syed Zamberi 
Published: May 2019

Learning outcomes
By reading and understanding the case study, Students will be able to link the importance of healthy life style and the physical exercise to the fitness industry in the UAE society, to reduce the growing percentage of obesity and related diseases; identify the main challenges of Tone Fitness Ladies’ Studio (Tone); explore the market segmentation of fitness centers in UAE based on a benefits segmentation of fitness industry; identify the demographic segmentation of Tone Fitness studio and the effects of considering gender and age; and develop individual perspectives of how Tone Fitness ladies’ studio may overcome the challenges to compete in the UAE fitness market.

Case overview/synopsis
Three sisters from the United Arab Emirates (Hind, Mariam and Amna Mohamed Omer) have established a fitness studio for women in Al Maqta’a (formerly known as Bain al Jasrain) on the eastern side of Abu Dhabi. Each of them shared a passion for sport, which led them to realize their business idea of setting up a fitness studio specifically for women. An understanding of Emirati culture and the needs of women in their society inspired them to think of a special place where women could find relief from work and life demands while also exercising pursuant of a healthy lifestyle. They launched Tone Ladies’ Fitness Studio (Tone) in September 2014, the first fitness studio for women in Al Maqta’a. The studio is in the same building as a cooperative hypermarket – a very good location because it is visited by many people and has ample parking spaces. Partly due to growing interest among Abu Dhabi residents in fitness and health, new fitness studios opened nearby in 2016, with competitors offering excellent services at reasonable prices. While the demand for fitness and healthy lifestyle pursuits is high in the region, the market has also expanded greatly to meet this demand, with many high-quality options becoming available. As a result of this, businesses such as Tone are facing serious threats to their sustainability. Thus, first, how can the Omer sisters sustain their business and strategize to maintain customers in their market segment? Second, what could they do to improve the market position of Tone in the UAE fitness market?

Complexity academic level
This case study is suitable for advanced level of diploma certificate in marketing or undergraduate student of marketing field.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 8: Marketing
Creativity and forms of managerial control in innovation processes: tools, viewpoints and practices
Authors: Bollinger Sophie Raedersdorf 
Published: May 2019

Purpose
Innovation processes are inherently uncertain. They account for a high proportion of risks taken by companies and cause tensions. The purpose of this paper is to consider whether some management tools facilitate the smooth implementation of an innovation process. Does the relevance of these tools depend on the size of the company, its activity sector, the type of innovation expected or the viewpoint of the manager in charge?

Design/methodology/approach
The author answers these questions using a quantitative questionnaire survey of 169 companies. This survey allows the author to describe the tools and practices of management control of innovation processes and to highlight the specific needs of different sets of companies.

Findings
The collected data show a convergence of tools and practices used, which the literature on managerial control and creativity helps us to understand.

Originality/value
The paper also contributes to reconciling management control and innovation activities. In particular, it investigates how the use of management tools varies depending on managers’ viewpoints. A distinction is made between formal, information system-based tools and more informal, human relationship-based tools.
Study of Asian RDR based on re3data
Authors: Cho Jane 
Published: May 2019

Purpose
RDR has become an essential academic infrastructure in an atmosphere that facilitates the openness of research output granted by public research funds. This study aims to understand operational status of 152 Asian data repositories on re3data and cluster repositories into four groups according to their operational status. In addition, identify the main subject areas of RDRs in Asian countries and try to understand what topic correlations exist between data archived in Asian countries.

Design/methodology/approach
This study extracts metadata from re3data and analyzes it in various ways to grasp the current status of research data repositories in Asian countries. The author clusters the repositories into four groups using hierarchical cluster analysis according to the level of operation. In addition, for identifying the main subject areas of RDRs in Asian countries, extracted the keywords of the subject field assigned to the each repository, and Pathfinder Network (PFNET) analysis is performed.

Findings
About 70 per cent of the Asian-country repositories are those where licenses or policies are declared but not granted permanent identifiers and international-level certification. As a result of the subject domain analysis, eight clusters are formed centering on life sciences and natural sciences.

Originality/value
The research output in developing countries, especially non-English-speaking countries, tends not to be smoothly circulated in the international community due to the immaturity of the open-access culture, as well as linguistic and technical problems. This study has value, in that it investigates the status of Asian countries’ research data management and global distribution infrastructure in global open-science trends.
In-flight reconfiguration of lithium-ion cells aimed at extending flight times and range of electrically powered UAVs
Authors: Zabunov Svetoslav , Mardirossian Garo 
Published: May 2019

Purpose
The purpose of this paper is to disclose a novel reconfiguration battery design suitable for electrically powered UAVs.

Design/methodology/approach
A design of a reconfigurable battery module is presented. Test setup with prototype battery module is developed and described. Test results of measurements are shown and discussed.

Findings
The results ascertain the benefits of implementing a reconfigurable battery in small electrically powered UAVs and specifically prove the efficiency of the proposed design.

Originality/value
The proposed novel design is compared to previous work while advances from the latter and the gained advantages were established.
Supply chain inclusion in base of the pyramid markets
Authors: Rosca Eugenia , Möllering Guido , Rijal Arpan , Bendul Julia Christine 
Published: May 2019

PurposeThe purpose of this paper is to explore mechanisms of supply chain inclusion in Base of the Pyramid (BOP) settings. It distinguishes micro-, small- and medium-sized enterprises (MSME)-led local supply chains on the one hand and multinational enterprises (MNEs)-led global supply chains on the other hand. This paper aims to answer the following research question: Which mechanisms of supply chain inclusion are employed empirically by MSMEs and how can these mechanisms influence social impact creation in MNE-led global supply chains?Design/methodology/approachA large-scale empirical study of MSMEs operating in BOP markets is performed and a cluster analysis conducted to systematically categorize supply chain inclusion. The cluster analysis and current literature yield theory-based implications for MNE-led global supply chains.FindingsThe cluster analysis reveals three meaningful clusters of supply chain inclusion in BOP markets and highlights two main aspects. They include direct vs indirect mechanisms of inclusion and diversity in supplier relationships with local organizations aimed at either “sourcing” local capabilities needed for inclusion or “outsourcing” the inclusion. Based on these aspects, two scenarios are proposed and evaluated for local-global supply chain symbiosis.Research limitations/implicationsThis study aims to contribute to the existing literature with a more fine-grained understanding of the inclusion of BOP actors in local supply chains and by proposing alternative trajectories for global supply chain inclusion.Practical implicationsThe findings outline several important decisions that managers need to make to include BOP actors in supply chain activities.Originality/valueThis paper contributes a novel, combined perspective of local supply chains (MSMEs) and global supply chains (MNEs).
The management of first party fraud in e-tailing: a qualitative study
Authors: Amasiatu Chioma Vivian , Shah Mahmood Hussain 
Published: May 2019

Purpose
First-party fraud in which retail consumers commit fraud against retailers is a growing problem. However, to date studies on retail crime have focused almost entirely on fraudulent consumer behaviours in physical stores. With the growth of e-commerce, the losses to retailers from this fraud are growing so there is strong need to research this problem from multiple perspectives. The paper aims to discuss this issue.

Design/methodology/approach
The authors conducted three case studies and a total of 24 semi-structured interviews with retail managers, and evaluated their existing prevention-related documentation. Fraud management lifecycle theory was used to organise and discuss the findings.

Findings
The authors found that many retailers are treating this problem as just a cost of doing business online and have no detailed plans for dealing with this problem or any reporting to law enforcement agencies. However, they have begun working with delivery companies for delivery accuracy. Use of convenience stores as collection points is also showing early improvements.

Research limitations/implications
The small number of cases and interviews used is a limitation of this study. However, the authors believe that the findings are useful for advancing knowledge in this emerging research area.

Practical implications
This study provides insight into existing management practices in this domain, and makes recommendations on how to improve the management of first-party fraud. The study also makes a case for increased managerial interest and involvement in reducing first-party fraud. The study also helps bridge a glaring gap in existing literature and provides useful leads for further research.

Originality/value
To the authors’ knowledge, this is the first study to evaluate the existing practices employed to manage first-party fraud in e-retail.