bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breadth and Dynamics of HLA-A2– and HLA-B7–Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection
Authors: Lampen Margit H , Uchtenhagen Hannes , Blom Kim , Varnaitė Renata , Pakalniene Jolita , Dailidyte Laura , Wälchli Sébastien , Lindquist Lars , Mickiene Aukse , Michaëlsson Jakob , Schumacher Ton N , Ljunggren Hans-Gustaf , Sandberg Johan K , Achour Adnane , Gredmark-Russ Sara 
Published: July 2018

Abstract
Tick-borne encephalitis virus (TBEV) is a leading cause of viral meningoencephalitis in many parts of Europe and eastwards in Asia, with high morbidity and often long-term neurologic sequelae. With no treatment available, studies of the immune response to TBEV are essential for the understanding of the immunopathogenesis of tick-borne encephalitis and for the development of therapeutics. We have previously demonstrated that CD8+ T cell responses in peripheral blood in patients with acute TBEV peak at around 7 d after hospitalization in the neuroinvasive phase of the disease. In this study, we identified six novel TBEV HLA-A2– and HLA-B7–restricted epitopes, all derived from the nonstructural proteins of TBEV. This identification allowed for a comprehensive phenotypic and temporal analysis of the HLA-A2– and HLA-B7–restricted Ag-specific CD8+ T cell response during the acute stages of human TBEV infection. HLA-A2– and HLA-B7–restricted TBEV epitope–specific effector cells predominantly displayed a CD45RA−CCR7−CD27+CD57− phenotype at day 7, which transitioned into separate distinct phenotypes for HLA-A2– and HLA-B7–restricted TBEV-specific CD8+ T cells, respectively. At day 21, the most prevalent phenotype in the HLA-A2–restricted CD8+ T cell populations was CD45RA−CCR7−CD27+CD57+, whereas the HLA-B7–restricted CD8+ T cell population was predominantly CD45RA+CCR7−CD27+CD57+. Almost all TBEV epitope–specific CD8+ T cells expressed α4 and β1 integrins at days 7 and 21, whereas the bulk CD8+ T cells expressed lower integrin levels. Taken together, human TBEV infection elicits broad responses to multiple epitopes, predominantly derived from the nonstructural part of the virus, establishing distinct maturation patterns for HLA-A2– and HLA-B7–restricted TBEV epitope–specific CD8+ T cells.
Rhabdovirus-Inducible MicroRNA-210 Modulates Antiviral Innate Immune Response via Targeting STING/MITA in Fish
Authors: Xu Tianjun , Chu Qing , Cui Junxia 
Published: July 2018

Abstract
Viral infection induces type I IFN production, which plays critical roles in orchestrating the antiviral defense by inducing direct antiviral activities. To establish a persistent infection, viruses have evolved numerous strategies to specifically interfere with IFN production or its downstream mediators, thereby evading the immune responses. MicroRNAs (miRNAs) are a family of small noncoding RNAs that posttranscriptionally regulate the expressions of specific target genes. Although accumulating evidence demonstrates that miRNAs play vital roles in regulating viral infection, miRNAs that target intracellular sensors and adaptors of innate immunity have not been fully uncovered. In this paper, we identify fish miR-210 as a robust regulator involved in regulating virus–host interactions. We found that rhabdovirus significantly upregulated the expression of fish miR-210. Inducible miR-210 modulates virus-triggered type I IFN and inflammatory cytokine production by targeting stimulator of IFN genes (STING), thereby promoting viral replication. Furthermore, we demonstrated that miR-210 regulates innate immune response through NF-κB, IFN regulatory factor 3, and JAK/STAT signaling pathways. The collective findings indicate that inducible miR-210 plays a regulatory role in virus–host interactions through STING-mediated singling pathway by targeting STING.
Association of esophageal dilatation in chest CT scan with gastroesophageal reflux disease: A case control study
Authors: Hashemi Seyed Jalal , Javad Moosavi Seyed Ali , Idani Esmaeil , Javaherforoushzadeh Ali , Raji Hanieh 
Published: July 2018

The presence of increased air bubble in the lumina of esophagus on a chest CT scan may be associated with esophageal disorders. The purpose of this study was to determine the association between the appearance of air bubbles on chest CT scan and gastroesophageal Reflux Disease (GERD). In this case-control study, thirty-two patients with endoscopically proved GERD and 32 subjects without GERD underwent chest computed tomography (CT) scanning. Esophageal dilatation (ED) was defined as the presence of air bubbles greater than 10 mm in the supra ventricle (SV) and ventricle (CV), and air bubbles >15 mm in the ventricle to the lower esophageal sphincter (V-LES). The results were compared between the two groups. The GERD patients included 16 (50%) males with a mean age of 58.5Â±11.2 years and the control group included 17 (54.8%) males and 14 (45.1%) females with a mean age of 66.7Â±10.5 years. There was a significant relationship between the presence of GERD and esophageal dilation (ED) in the V-LES sections on the CT scan (P=0.002). The mean size of the air bubbles in the V-LES section was 11.73 mm in the case group in comparison to 4.32 mm in the control group (P<0.001). Â The size and location of the air bubbles in the esophagus can vary and be important. The possibility of GERD increases in the presence of esophageal dilation on CT scan.
Eleven years of mountain weather, snow, soil moisture and streamflow data from the rain–snow transition zone – the Johnston Draw catchment, Reynolds Creek Experimental Watershed and Critical Zone Observatory, USA
Authors: Godsey Sarah E. , Marks Danny , Kormos Patrick R. , Seyfried Mark S. , Enslin Clarissa L. , Winstral Adam H. , McNamara James P. , Link Timothy E. 
Published: July 2018

Abstract. Detailed hydrometeorological data from the rain-to-snow transition
zone in mountain regions are limited. As the climate warms, the
transition from rain to snow is moving to higher elevations, and
these changes are altering the timing of downslope water
delivery. To understand how these changes impact hydrological and
biological processes in this climatologically sensitive region,
detailed observations from the rain-to-snow transition zone are
required. We present a complete hydrometeorological dataset for
water years 2004 through 2014 for a watershed that spans the
rain-to-snow transition zone
(https://doi.org/10.15482/usda.adc/1402076). The
Johnston Draw watershed (1.8 km2), ranging from
1497 to 1869 m in elevation, is a sub-watershed of the
Reynolds Creek Experimental Watershed (RCEW) in southwestern Idaho,
USA. The dataset includes continuous hourly hydrometeorological
variables across a 372 m elevation gradient, on north- and
south-facing slopes, including air temperature, relative humidity,
and snow depth from 11 sites in the watershed. Hourly measurements
of incoming shortwave radiation, precipitation, wind speed and
direction, soil moisture, and soil temperature are available at
selected stations. The dataset includes hourly stream discharge
measured at the watershed outlet. These data provide the scientific
community with a unique dataset useful for forcing and validating
hydrological models and will allow for better representation and
understanding of the complex processes that occur in the
rain-to-snow transition zone.
Avaliação de impacto de periódicos brasileiros de extensão universitária
Authors: Coelho Geraldo Ceni 
Published: July 2018

Objetivo. Os periódicos acadêmicos multidisciplinares revisados por pares dedicados à extensão universitária (ReX) são relativamente numerosos no Brasil. Estudos sobre seu impacto são escassos. O objetivo desta investigação foi verificar se as ReX apresentam diferenças bibliométricas em relação a outros periódicos multidisciplinares brasileiros (RMulti).Método. Foram calculados índices de citação, tendo como base o mecanismo de busca Google Acadêmico (GA) para os dois grupos. Ainda, foi avaliada a relação entre os índices e a classificação WebQualis.Resultados. Verificou-se que o fator de impacto baseado nas citações do GA (FGA) é bastante variável entre os periódicos, e não difere entre os grupos. O índice h5 (GA) apresenta uma correlação não significativa com o FGA quanto se consideram todos os periódicos (r2 = 0,51, P = 0,0686). Entre as RMulti, observa-se uma alta correspondência entre a maior classificação WebQualis e o fator de impacto baseado no GA (FGA), assim como entre a mediana WebQualis e o FGA. Por outro lado, tal correspondência não é observada entre as ReX. Conclusões. As ReX tem uma valorização, no Webqualis, aquém de seu impacto.
La "creatividad integrada" desde el análisis de experiencias artísticas con personas con capacidades diversas en espacios académicos
Authors: Santos Sánchez-Guzmán Eva , Mesas Escobar Eva Cristina 
Published: July 2018

El presente artículo surge de las actividades creativas que en los últimos años hemos venido desarrollando con personas con síndrome de Down y estudiantes de la Universidad de Murcia en ámbitos académicos, desde los que hemos ido conformando un espacio para la creatividad integrada, que permitiera la participación de personas con o sin discapacidad intelectual en las mismas posibilidades, favoreciéndonos del enriquecimiento mutuo y del aprendizaje de las relaciones diversas a través de herramientas creativas. Desde estas líneas queremos mostrar los encuentros que sirvieron de manantial a la consolidación del curso de creación integrada con personas con síndrome de Down. A partir de estos cruces creativos que giran alrededor de la creación diversa, surge la necesidad de reflexionar en torno al sujeto y su construcción a través de la intersubjetividad, así como en la búsqueda de metodologías propias que favorezcan los espacios para la integración a través de la creatividad, introduciendo estrategias clave, tales como: creación integrada, diálogo, interacción, juego, experimentación y encuadre propio, que nos han permitido reformular el concepto de creatividad integrada, así como elaborar algunas conclusiones esenciales.
Discurso paulista de modernidade e o museu: Yolanda Penteado, dos salões de arte aos museus regionais do nordeste (1903-1968)
Authors: Pausini Adel Igor Romanov 
Published: July 2018

Na Paris do século XIX, era hábito comum entre os aristocratas a promoção de encontros entre pessoas de alta condição social com grupos da intelectualidade para concertos, espetáculos, bailes, tertúlias e demais eventos de salão em ambiente residencial. No Brasil, os salões ganham força no segundo reinado, sobretudo na capital do Império, estendendo o seu prestígio à florescente São Paulo do café no final do século XIX, tornando-se uma autêntica instituição da Belle Époque, tendo como os mais prestigiados os salões de Veridiana da Silva Prado, José de Freitas Valle, Paulo Prado e Olívia Guedes Penteado. Nestes espaços, a aristocracia paulista consolidava o capital social utilizado, o mecenato e a ação pública e privada para a promoção dos próprios interesses, projetos e perspectivas do país. Na década de 1930, os salões perdem força em detrimento da organização de sociedades e grupos de artistas, o que produz, em alguns casos, relativa independência em relação ao mecenato público e privado, permitindo o avanço de experiências de tendências anarquistas e comunistas, rapidamente revertidas enquanto plano hipotético na década de 1940 com a abertura dos grandes museus e eventos de arte em São Paulo, a internacionalização da arte e o financiamento norte-americano, em contexto de Guerra Fria. O êxito do projeto paulista, capitalista, urbano-industrial de museus é levado pela velha aristocracia, ressignificada e financiada pelo capital industrial emergente para outras regiões do país em pleno contexto nacional do regime militar de desenvolver e integrar. Por meio do mecenato exercido de distintos modos, a aristocracia paulista defendeu e implementou, em alguma medida, o seu projeto de modernização conservadora no século XIX e XX, defendendo os seus interesses por meio dos salões e dos museus de arte.
Tendência da produção científica sobre avaliação em atenção primária à saúde
Authors: Amaral José Carlos Anziliero , Weiller Teresinha Heck , Souza Rafaela 
Published: July 2018

Objetivo: analisar a tendência das produções científicas brasileiras acerca da avaliação em atenção primária à saúde. Método: revisão narrativa com base nas dissertações e teses defendidas nos diferentes programas de pós-graduação e disponibilizadas no banco de teses e dissertações do portal da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, em maio de 2015. Resultados: a busca foi realizada utilizando o termo “avaliação em atenção primária à saúde”, obtendo 292 resultados. Destes, 81 estudos foram selecionados após análise temática, desenvolvendo-se a categorização com base na semelhança entre os estudos. Considerações finais: as avaliações em atenção primária à saúde foram desenvolvidas a partir de instrumentos sistematizados e validados, e estão centradas na observação de um ou mais atributos essenciais da atenção primária (a atenção no primeiro contato, a continuidade ou longitudinalidade, a integralidade e a coordenação da atenção).
A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine‐IR820 Prodrug Encapsulated ZIF‐8 toward Chemo‐Photothermal Therapy
Authors: Zhang Huiyuan , Li Qian , Liu Ruiling , Zhang Xinke , Li Zhonghao , Luan Yuxia 
Published: July 2018

AbstractZeolitic imidazolate framework‐8 (ZIF‐8) is an attractive metal organic framework (MOF) in drug delivery. Strong interaction between drugs and ZIF‐8 is essential for high drug loadings through in situ construction of MOFs. However, only limited drugs with unique functional groups (COOH, SO3H, et al.) can interact with ZIF‐8 and be encapsulated satisfactorily so far. Drugs without these functional groups are difficult to be loaded due to the lack of strong interaction. Herein a versatile prodrug strategy is proposed to solve the problems encountered by MOFs. Cytarabine (Ara) is chosen as a model drug since it cannot be loaded in ZIF‐8 satisfactorily by itself. New indocyanine green (IR820) is utilized to bond with Ara for the formation of prodrug (Ara‐IR820) and endows the prodrug with fluorescence imaging‐guided chemo‐photothermal therapy, in which sulfonic groups strengthen the interaction between prodrug and ZIF‐8. This prodrug loaded ZIF‐8 is further functionalized with hyaluronic acid (HA) to result in active‐targeting HA/Ara‐IR820@ZIF‐8 nanoparticles. The in vitro and in vivo results demonstrate its excellent visual cancer therapy with tumor‐targeted and pH‐responsive release behavior. This design offers a new concept to solve the drug loading problem of MOFs, exhibiting a flexible strategy to expand the biomedical applications of MOFs.
Bioinspired Electrically Activated Soft Bistable Actuators
Authors: Shao Huiqi , Wei Shuzhen , Jiang Xin , Holmes Douglas P. , Ghosh Tushar K. 
Published: July 2018

AbstractMovement and morphing in biological systems provide insights into the materials and mechanisms that may enable the development of advanced engineering structures. The nastic motion of plants in response to environmental stimuli, e.g., the rapid closure of the Venus flytrap's leaves, utilizes snap‐through instabilities originating from anisotropic deformation of plant tissues. In contrast, ballistic tongue projection of chameleon is attributed to direct mechanical energy transformation by stretching elastic tissues in advance of rapid projection to achieve higher speed and power output. Here, a bioinspired trilayered bistable all‐polymer laminate containing dielectric elastomers (DEs) is reported, which double as both structural and active materials. It is demonstrated that the prestress and laminating strategy induces tunable bistability, while the electromechanical response of the DE film enables reversible shape transition and morphing. Electrical actuation of bistable structures obviates the need for continuous application of electric field to sustain their transformed state. The experimental results are qualitatively consistent with our theoretical analyses of prestrain‐dependent shape and bistability.
Excitation and Amplification of Spin Waves by Spin–Orbit Torque
Authors: Divinskiy Boris , Demidov Vladislav E. , Urazhdin Sergei , Freeman Ryan , Rinkevich Anatoly B. , Demokritov Sergej O. 
Published: July 2018

AbstractThe emerging field of nanomagnonics utilizes high‐frequency waves of magnetization—spin waves—for the transmission and processing of information on the nanoscale. The advent of spin‐transfer torque has spurred significant advances in nanomagnonics, by enabling highly efficient local spin wave generation in magnonic nanodevices. Furthermore, the recent emergence of spin‐orbitronics, which utilizes spin–orbit interaction as the source of spin torque, has provided a unique ability to exert spin torque over spatially extended areas of magnonic structures, enabling enhanced spin wave transmission. Here, it is experimentally demonstrated that these advances can be efficiently combined. The same spin–orbit torque mechanism is utilized for the generation of propagating spin waves, and for the long‐range enhancement of their propagation, in a single integrated nanomagnonic device. The demonstrated system exhibits a controllable directional asymmetry of spin wave emission, which is highly beneficial for applications in nonreciprocal magnonic logic and neuromorphic computing.
A High‐Rate and Stable Quasi‐Solid‐State Zinc‐Ion Battery with Novel 2D Layered Zinc Orthovanadate Array
Authors: Chao Dongliang , Zhu Changrong (Rose) , Song Ming , Liang Pei , Zhang Xiao , Tiep Nguyen Huy , Zhao Haofei , Wang John , Wang Rongming , Zhang Hua , Fan Hong Jin 
Published: July 2018

AbstractZinc‐ion batteries are under current research focus because of their uniqueness in low cost and high safety. However, it is still desirable to improve the rate performance by improving the Zn2+ (de)intercalation kinetics and long‐cycle stability by eliminating the dendrite formation problem. Herein, the first paradigm of a high‐rate and ultrastable flexible quasi‐solid‐state zinc‐ion battery is constructed from a novel 2D ultrathin layered zinc orthovanadate array cathode, a Zn array anode supported by a conductive porous graphene foam, and a gel electrolyte. The nanoarray structure for both electrodes assures the high rate capability and alleviates the dendrite growth. The flexible Zn‐ion battery has a depth of discharge of ≈100% for the cathode and 66% for the anode, and delivers an impressive high‐rate of 50 C (discharge in 60 s), long‐term durability of 2000 cycles at 20 C, and unprecedented energy density ≈115 Wh kg−1, together with a peak power density ≈5.1 kW kg−1 (calculation includes masses of cathode, anode, and current collectors). First principles calculations and quantitative kinetics analysis show that the high‐rate and stable properties are correlated with the 2D fast ion‐migration pathways and the introduced intercalation pseudocapacitance.
High‐Performance, Micrometer Thick/Conformal, Transparent Metal‐Network Electrodes for Flexible and Curved Electronic Devices
Authors: Liu Jianpeng , Xiao Lin , Rao Zhefan , Dong Biyang , Yin Zhouping , Huang YongAn 
Published: July 2018

AbstractMetal‐network electrodes (MNEs) are excellent substitutes to the brittle and expensive indium tin oxide (ITO) films for flexible and transparent electronic devices. For a high transmittance and low resistivity, highly ordered metal wire arrays with suitable gap and width are essential. Here, high‐orderly and dimension‐controllable ultrathin/conformal MNEs are fabricated on µm thick/curved substrate via programmable electrohydrodynamic (EHD) lithography. By employing EHD direct‐writing, large‐scale high‐resolution photoresist micro/nano‐pattern can be digitally printed on ultrathin/curved substrates, as the digital mask in chemical etching process. The Au MNEs show transmittance of 94.3% (at 600 nm optical wavelength) and sheet resistance of 36.7 Ω□−1 with the optimum pattern which can be adjusted by theoretical analysis. MNEs fabricated on ultrathin polymeric substrate (≈1.5 µm thickness) can even be hanged on a hair. A flexible and transparent touch panel with MNEs exhibits excellent mechanical durability on a small‐bending radius. Additionally, the MNEs are mounted on a fingertip as a “fingertip mouse”, which is perfectly conformal with fingerprints and can successfully control the computer directly by two fingers. Not limited to planar devices, the MNEs also can be perfectly fabricated on a nonplanar glass and form a transparent conformal heater.
3D Heterostructured Copper Electrode for Conversion of Carbon Dioxide to Alcohols at Low Overpotentials
Authors: Daiyan Rahman , Saputera Wibawa Hendra , Zhang Qingran , Lovell Emma , Lim Sean , Ng Yun Hau , Lu Xunyu , Amal Rose 
Published: July 2018

AbstractActive and cost‐effective catalyst materials are required for electrochemical CO2 reduction reactions (CO2RR) which, to date, are proving elusive. Here, the direct electrochemical conversion of CO2 to liquid products with a high overall Faradaic efficiency (FE) by utilizing a unique 3D, heterostructured copper electrode (referred as Cu sandwich) that is obtained via a simple two‐step treatment of commercially available copper foam is reported. The designed catalyst achieves an FE toward liquid products of >50% at an applied potential as low as −0.3 V versus reversible hydrogen electrode. The improved selectivity of the heterostructured Cu sandwich electrode at low overpotentials is attributed to the greater exposure of engineered Cu+/Cu2+ interfaces (present on composite nanowires) and higher oxygen vacancy defects. Moreover, the rationally designed heterostructures prevent the Cu2O species from being reduced during CO2RR enabling the catalyst to demonstrate enhanced CO2RR activity with prolonged stability.
Thermische Materialeigenschaften von Brandschutzmaterialien für Naturbrandbeanspruchungen
Authors: Zehfuß Jochen , Sander Lisa , Schaumann Peter , Weisheim Waldemar 
Published: July 2018

AbstractZum Schutz von Stahlbauteilen vor einer Brandeinwirkung können Brandschutzmaterialien in Form von Brandschutzplatten, Brandschutzputzen oder reaktiven Brandschutzsystemen zur Anwendung kommen. Ihre thermische Schutzwirkung führt zu einer verzögerten Erwärmung des zu schützenden Stahlbauteils und gewährleistet dadurch einen ausreichend langen Feuerwiderstand. Die Brandschutzmaterialien werden i. d. R. anhand von Brandprüfungen nach der Einheits‐Temperaturzeitkurve (ETK) ausgelegt und entsprechende Verwendbarkeitsnachweise erstellt. Eine detaillierte Kenntnis der thermischen Materialeigenschaften der Brandschutzmaterialien ist hierfür nicht erforderlich. Die bauaufsichtlich eingeführten Eurocodes ermöglichen neben der Standardbemessung nach der ETK grundsätzlich auch eine leistungsbasierte Bemessung für ein natürliches Brandszenario. Im Gegensatz zur ETK, die von einem schnellen und kontinuierlichen Temperaturanstieg ausgeht, wird bei einem Naturbrandszenario ein realistisches Modell eines Brands (Entwicklungsphase, Vollbrand und Abkühlphase) abgebildet, dessen Verlauf in Abhängigkeit von den vorhandenen Brandlasten, den Ventilationsverhältnissen und der Brandraumgeometrie individuell ist. Die Auslegung der Schutzmaßnahmen für natürliche Brände kann daher nicht auf Grundlage der Standard‐Brandprüfungen erfolgen. Für die leistungsbasierte Bemessung brandbeanspruchter geschützter Stahlbauteile ist die temperaturabhängige Formulierung der thermischen Materialkennwerte sowohl für einen Temperaturanstieg als auch eine anschließende Abnahme der Brandbeanspruchung unabdingbar. Bis dato sind die thermischen Materialkennwerte von Brandschutzbekleidungen insbesondere für die Abkühlphase lückenhaft.In diesem Beitrag werden daher experimentelle Untersuchungen der thermischen Materialkennwerte von Brandschutzplatten, ‐putzen und reaktiven Brandschutzsystemen für die Aufheiz‐ und Abkühlphase vorgestellt.