bluuebunny/crossref_metadata_2025_split huggingface dataset:
BIODISTRIBUSI NANOMATERIAL 186Re-M41S-NH2 SEBAGAI RADIOFARMAKA UNTUK PROSEDUR RADIOSINOVEKTOMI PADA TIKUS NORMAL : STUDI PENDAHULUAN
Authors: Sugiharti Rizky Juwita , Daruwati Isti , Widyasari Eva Maria , Christina Maria 
Published: May 2019

AbstrakSTUDI AWALBIODISTRIBUSI NANOMATERIAL 186Re-M41S-NH2 SEBAGAI RADIOFARMAKA UNTUK PROSEDUR RADIOSINOVEKTOMI. Rheumatoid arthritis merupakan penyakit autoimun akibat reaksi antigen-antibodi pada lapisan membran sinovial yang menyebabkan kerusakan pada sendi. Salah satu prosedur radioterapi yang digunakan untuk meredakan nyeri dan inflamasi yang disebabkan oleh rheumatoid arthritis adalah radiosinovektomi yaitu dengan injeksi radioisotop pemancar sinar β secara intra-artikular ke dalam sendi sinovial. M41S-NH2adalah partikel ordered mesoporous silica dengan pori-pori seragam yang berikatan stabil dengan radioisotop renium-186 (186ReO4-) menjadi 186Re-M41S-NH2 yang dikembangkan sebagai radiofarmaka untuk prosedur radiosinovektomi. Untuk mengetahui pola biodistribusi dan stabilitas radiofarmaka 186Re-M41S-NH2 secara in vivo maka dilakukan uji biodistribusi dengan cara menyuntikan 186Re-M41S-NH2secara intra artikular ke dalam sendi tikus normal stok Sprague Dawley. Hasil uji biodistribusi 186Re-M41S-NH2, memperlihatkan partikel radiofarmaka 186Re-M41S-NH2 terakumulasi sebesar (96,80+3,92)% ID di dalam sendi lutut 3 jam pasca injeksi. Eksresi radiofarmaka 186Re-M41S-NH2di dalam urin setelah 24 jam adalah sebesar (6,11+0,5)% ID menunjukkan radiofarmaka ini cukup stabil di dalam rongga sendi. Data biodistribusi radiofarmaka 186Re-M41S-NH2memperlihatkan radioaktivitas yang sangat rendah di semua organ non target khususnya di hati dan limpa. Akumulasi radioaktivitas yang kecil di lambung menunjukkan radiofarmaka 186Re-M41S-NH2merupakan kompleks yang stabil secara in vivo dan tidak terurai menjadi ReO4-. Dari uji pendahuluan biodistribusi ini memperlihatkan bahwa radiofarmaka 186Re-M41S-NH2ini cukup ideal sebagai radiofarmaka yang dapat digunakan untuk prosedur radiosinovektomi.
Planejamento estratégico na promoção à saúde do idoso: uma experiência integradora academia-serviço-comunidade
Authors: Santos Carla Maria Lima , Pinheiro Ferreira Suélem Maria Santana , Almeida Carla Santos , Araújo Igor Brasil de , Marino Ana Caroline de , Menezes Valnice Machado 
Published: May 2019

INTRODUÇÃO: O planejamento em saúde pode ser compreendido como um dispositivo para sistematização das ações e facilitação na elaboração dos processos de trabalho, bem como para a formação de profissionais de saúde engajados à organização do Sistema Único de Saúde. OBJETIVO: Discutir o envolvimento de diversos atores sociais na construção coletiva do Planejamento Estratégico Situacional em um componente curricular da formação em saúde e levantar potenciais benefícios desse processo. MATERIAIS E MÉTODOS: Os discentes tiveram aporte teórico do Sistema Único de Saúde, Promoção da Saúde, Epidemiologia, Planejamento, Educação Popular durante os três semestres do componente curricular supracitado. No segundo semestre foi realizado diagnóstico situacional da população de um grupo de idosos da USF. Com base nesse diagnóstico, no terceiro semestre, juntamente à equipe da USF, docentes e os idosos, foi realizado Planejamento Estratégico Situacional (PES), sob os moldes de Carlos Matus, de intervenções comunitárias com base na Educação Popular em Saúde. RESULTADOS: O PES, com a participação de todos os atores, possibilitou a horizontalidade das relações em todas as etapas, desde o planejamento até a execução das atividades. Foram realizadas 5 intervenções comunitárias com os idosos, com posterior avaliação e monitoramento das ações. CONCLUSÃO: Os resultados apontam para o papel potencializador dessa prática integradora e a importância da vivência no SUS desde o início do percurso acadêmico.
Vitamin C in fleshy fruits: biosynthesis, recycling, genes, and enzymes
Authors: Tyapkina D. Y. , Kochieva E. Z. , Slugina M. A. 
Published: May 2019

L-ascorbic acid (vitamin C) is a plant secondary metabolite that has a variety of functions both in plant tissues and in the human body. Plants are the main source of vitamin C in human nutrition, especially citrus, rose hip, tomato, strawberry, pepper, papaya, kiwi, and currant fruits. However, in spite of the biological significance of L-ascorbic acid, the pathways of its biosynthesis in plants were fully understood only in 2007 by the example of a model plant Arabidopsis thaliana. In the present review, the main biosynthetic pathways of vitamin C are described: the L-galactose pathway, L-gulose pathway, galacturonic and myo-inositol pathway. To date, the best studied is the L-galactose pathway (Smyrnoff–Wheeler pathway). Only for this pathway all the enzymes and the entire cascade of reactions have been described. For other pathways, only hypothetical metabolites are proposed and not all the catalyzing enzymes have been identified. The key genes participating in ascorbic acid biosynthesis and accumulation in fleshy fruits are highlighted. Among them are L-galactose pathway proteins (GDP-mannose phosphorylase (GMP, VTC1), GDP-D-mannose epimerase (GME), GDP-L-galactose phosphorylase (GGP, VTC2/VTC5), L-galactose-1-phosphate phosphatase (GPP/VTC4), L-galactose-1-dehydrogenase (GalDH), and L-galactono1,4-lactone dehydrogenase (GalLDH)); D-galacturonic pathway enzymes (NADPH-dependent D-galacturonate reductase (GalUR)); and proteins, controlling the recycling of ascorbic acid (dehydroascorbate reductase (DHAR1) and monodehydroascorbate reductase (MDHAR)). Until now, there is no clear and unequivocal evidence for the existence of one predominant pathway of vitamin C biosynthesis in fleshy fruits. For example, the L-galactose pathway is predominant in peach and kiwi fruits, whereas the D-galacturonic pathway seems to be the most essential in grape and strawberry fruits. However, in some plants, such as citrus and tomato fruits, there is a switch between different pathways during ripening. It is noted that the final ascorbic acid content in fruits depends not only on biosynthesis but also on the rate of its oxidation and recirculation.
An Innovative Tour Recommendation System using Graph Algorithms
Authors: Hossain Md. Sabir , Tanim Ahsan Sadee , Nawal Nabila , Akter Sharmin 
Published: May 2019

Background: Tour recommendation and path planning are the most challenging jobs for tourists as they decide Points of Interest (POI).Objective: To reduce the physical effort of the tourists and recommend them a personalized tour is the main objective of this paper. Most of the time people had to find the places he wants to visit in a difficult way. It kills a lot of time.Methods: To cope with this situation we have used different methodology. First, a greedy algorithm is used for filtering the POIs and BFS (Breadth First Search) algorithm will find POI in terms of user interest. The maximum number of visited POI within a limited time will be considered. Then, the Dijkstra algorithm finds the shortest path from the point of departure to the end of tours.Results: This work shows its users list of places according to the user's interest in a particular city. It also suggests them places to visit in a range from the location of the user where a user can dynamically change this range and it also suggests nearby places they may want to visit.Conclusion: This tour recommendation system provides its users with a better trip planning and thus makes their holidays enjoyable.
DA’WA, MUSLIM MILLENNIALS AND SOCIAL MEDIA
Authors: Zulhazmi Abraham Zakky , Hastuti Dewi Ayu Sri 
Published: May 2019

The link between religion and cyberspace has become a necessity in the cyber era. The internet, in this case social media, changes many patterns and forms of communication. Social media has become a massive channel used by Indonesian preachers for the past decade or so. Da'wah on social media presents a number of challenges and opportunities, especially when dealing with millennials as majority users. This study intends to describe the phenomenon of da'wah on social media among millennial Muslims. This research is a descriptive qualitative research with literature study as a data collection method. The conclusion of this study is that there are three main points in viewing da'wa, millennial Muslims and social media. First, the character of millennial generation who tend to be out of the box and always connected to the internet more or less changes the da'wah landscape in Indonesia. They slowly leave the conventional da'wa, both in terms of theme and method choices. The popularity Hanan Attaki’s da’wah became one of the markers. Secondly, social media despite having a positive contribution to da'wah but also left a number of notes that demand attention, such as prejudice, easy spread of hate speech, reluctance to access primary sources and quality filter problems. Third, looking at millennial generations who have the characteristics of tolerance, pluralism and being able to appreciate diversity brings opportunities for the development of moderate Islamic da'wah in Indonesia. Keywords: da’wah, millenial, social media
Upaya Pencapaian Daya Saing Usaha Sapi Perah Melalui Kebijakan Pemerintah dan Peningkatan Pendapatan Peternak
Authors: Rusdiana Supardi , Soeharsono Soeharsono 
Published: May 2019

Menghadapi persaingan usaha ternak sapi perah dapat diupayakan melalui pengembangan industri peterakan yang mengarah pada usaha komersial. Usaha ternak sapi perah induk laktasi, dapat diarahkan pada peningkatan ekonomi dan kesejahteraan peternak. Berdasarkan permasalahan tersebut diatas, terlihat upaya pencapaian daya saing usaha sapi perah dipeternak masih lemah, sehingga dibutuhkan dukungan modal usaha. Tulisan ini bertujuan membahas mengenai tinjauan konseptual upaya pencapaian daya saing usaha sapi perah melalui kebijakan pemerintah dan peningkatan pendapatan peternak. Upaya Pemerintah untuk menciptakan berbagai produk hasil peternakan dapat bersaing dan mampu memotori industrialisasi perdesaan. Kebijakan Pemerintah dengan meningkatkan tarif impor pada produk susu sapi perah akan berpengaruh positif terhadap daya saing usaha ternak sapi perah di peternak. usaha ternak sapi perah di peternak akan semakin meningkat nilai keuntungan secara kompetitif dan keunggulan komparatif. Produksi susu sapi perah yang dihasikan dapat memenuhi kebutuhan pasar, dan secara tidak langsung perekonmian peternak meningkat. Usaha sapi perah dengan skala 4 ekor induk laktasi, peternak mendapatkan keuntungan bersih sebesar Rp.21.007.000,-/tahun R/C ratio 1,5. Keuntungan pada kelompok peternak sapi perah Maju Terus sebesar Rp.1.718.794,53,-/tahun nilai R/C ratio 2,18. Ke dua usaha sapi perah di peternak nilai R/C rasio sangat baik dan &gt;1. Usaha ternak sapi perah di peternak secara ekonomi layak untuk diusahakan kembali.
APEX-seq: RNA subcellular localization by proximity labeling
Authors: Fazal Furqan M. , Han Shuo , Parker Kevin R. , Kaewsapsak Pornchai , Xu Jin , Boettiger Alistair , Chang Howard Y. , Ting Alice Y. 
Published: May 2019

Abstract
We introduce APEX‑seq, a method for RNA sequencing based on direct proximity labeling of RNA using the peroxidase enzyme APEX2. APEX‑seq in nine distinct subcellular locales produced a nanometer-resolution spatial map of the human transcriptome as a resource, revealing extensive and exquisite patterns of localization for diverse RNA classes and transcript isoforms. APEX‑seq should be widely applicable to many systems, enabling comprehensive investigations of the spatial transcriptome.
Experimental study on the hydraulic capacity of grate inlets with supercritical surface flow conditions
Authors: Kemper Svenja , Schlenkhoff Andreas 
Published: May 2019

Abstract
Due to an increasing number of heavy rainfall events, the managing of urban flooding requires new design approaches in urban drainage engineering. With bidirectional coupled numerical models the surface runoff, the underground sewer flow and the interaction processes between both systems can be calculated. Most of the numerical models use a weir equation to calculate the surface to sewer flow with unsurcharged flow conditions, but uncertainties still exist in the representation of the real flow conditions. Street inlets, existing in different types, are the connecting elements between the surface and the underground system. In the present study, an empirical formula was developed based on physical model test runs to estimate the hydraulic capacity and type-specific efficiency of grate inlets with supercritical surface flow. Influencing hydraulic parameters are water depth and flow velocity upstream of the grate and, in addition, different geometrical parameters are taken into account, such as the grate dimensions or the orientation of the bars (transverse, longitudinal or diagonal). Good agreement between estimated and measured results could be proven with relative deviations less than 1%.
Adipic Acid as a Biodegradable Solid Acid Catalyst for One-Pot, Three Component Synthesis of 1-Amidoalkyl-2-naphthols
Authors: Darbandi Hassan , Kiyani Hamzeh 
Published: May 2019

Background:
1-Amidoalkyl-2-naphthols are an attractive group of organic compounds
that can be converted to oxazine heterocycles and aminoalkyl naphthols. The derivatives of 1-
amidoalkyl-2-naphthols have significant biological activities and act as drug candidates.

Methods:
1-Amidoalkyl-2-naphthols were synthesized via the three-component condensation reaction
of 2-naphthol, acetamide/benzamide and various aldehydes in the presence of 10 mol% of adipic
acid as an organocatalyst under solvent-free conditions at 120°C.

Results:
A simple, efficient, and operative method for the synthesis of 1-amidoalkyl-2-naphtholes in
the presence of adipic acid as the biodegradable catalyst is introduced. Easy operation, acceptable reaction
times, eco-friendly, availability of starting materials, simple separation of products, and high
yields of products are the significant results of this method.

Conclusion:
In this study, 1-amidoalkyl-2-naphthols were synthesized using commercially available
reactants in excellent yields and relatively shorter times. In this process, microwave or ultrasonic
waves were not used to provide energy for the reaction.
High Catalytic Activity of Pd Nanoparticles Synthesized from Green Alga Chlorella vulgaris in Buchwald-hartwig Synthesis of N-Aryl Piperazines
Authors: Mishra Vaibhav , Arya Anju , Chundawat Tejpal Singh 
Published: May 2019

Background:
The N-aryl piperazines are an important component of many drug products
used for the treatment of malaria, depression, anxiety and Parkinson diseases. Buchwald-Hartwig
amination is the latest and well-known reaction for Pd catalyzed direct synthesis of N-aryl piperazine
from aryl halides. Although several Pd-ligand systems have already been discovered for this conversion,
Pd nanoparticles are recently being used for this useful coupling reaction due to their recyclability
and durability. Metal nanoparticles show enhanced catalytic activity compared to their bulk counterparts
due to increased surface area at the edges and corners. The use of green algal extract in place
of chemical ligands makes this process more environment-friendly and cost-effective. In this research,
Pd nanoparticles synthesized using green alga C. Vulgaris were utilized as an alternative approach
for the coupling reaction during the preparation of N-aryl piperazines.

Methods:
Synthesized Pd nanoparticles from C. Vulgaris were characterized by FTIR, SEM and
XRD techniques. The catalytic activity of the synthesized nanoparticles was monitored for the synthesis
of N-aryl piperazines by Buchwald-Hartwig reaction. The synthesized N-aryl piperazines were
characterized by NMR, FTIR and mass analysis.

Results:
A very good catalytic activity of the synthesized Pd nanoparticles from green alga Chlorella
vulgaris extract was observed. The green alga not only reduces the size of the Pd metal to nanoparticles
but also acts as a green ligand for reduction of Pd(II) to Pd(0) during nanoparticle synthesis. Using
this Pd nanoparticles-green ligand system, several N-aryl piperazines were synthesized in good to
excellent yields. Reaction conditions for better conversion were optimized. The comparative advantage
of the catalytic system with recently published works on Buchwald-Hartwig C-N coupling
reaction is given. Recyclability and durability of the catalyst were explored and the results were
found to be promising. A plausible mechanism of Pd nanoparticle catalyzed reaction is also proposed.

Conclusion:
Catalytic activity of the Pd nanoparticle synthesized from Chlorella vulagris in the synthesis
of N-aryl piperazines by Buchwald-Hartwig reaction is reported first time to the best of our
knowledge and understanding. The green approach of Pd catalyst to facilitate the reaction and its environmental
impact is the main characteristic of the process.
DEVELOPMENT AND VALIDATION OF A GRADIENT HPLC METHOD FOR QUANTIFICATION OF EDETATE DISODIUM IN LYOPHILIZED INJECTABLE DRUG PRODUCT
Authors: DESHPANDE SHRIPAD , FAROOQUI MAZAHAR , GANAP GAJANAN , KHADKE VISHAL , KAYANDE D. D. 
Published: May 2019

Objective: The present study was aimed to validate a developed reversed phase gradient high-performance liquid chromatography method for the quantitative determination of Edetate Disodium in the lyophilized injectable drug product.
Methods: The amount of total Edetate disodium was analysed by HPLC assay using Edetate disodium USP as a reference standard. Injectable product was dissolved in acetone and Edetate disodium is separated out from API and then dissolved in water. Analysis was carried out using ferric chloride as a precolumn derivatizing reagent and YMC Pack ODS-A, 5 µm column with mobile phase as a mixture of tetrabutylammonium bromide buffer pH 2.8 and acetonitrile as the solvent, water used as diluent. The Edetate disodium quantified by U. V. wavelength at 254 nm.
Results: The method was suitably validated with respect to specificity, linearity, precision, accuracy and solution stability, using this method the average recovery from spike sample is 98.2%, with a relative standard deviation of<3%. The minimal quantifiable level was 1.5 µg/ml. The results show that the procedure is accurate, precise and reproducible.
Conclusion: In the present study an attempt has been made to develop and validate the analytical method for lyophilised injectable formulations and to generate the scientific database for formulation and evaluation of various lyophilised injectable containing Edetate disodium.
FACTORS AFFECTING THE INCIDENCE OF RABIES DISEASE IN PUSKESMAS REJOSARI PEKANBARU CITY
Authors: Parlin Winda 
Published: May 2019

<p>Rabies is a disease caused by the rabies virus. Rabies attacks can cause death. Based on data from Pekanbaru City Health Department found that the highest rabies cases were 15 cases in Puskesmas Rejosari. The purpose was to determine the factors that influence the incidence of rabies. This research is quantitative analytical research with case control design<em>. </em>The respondents are 30 divided by 15 cases of rabies and 15 people as a control. Data were analyzed using univariate and bivariate with <em>chi square </em>test.The results are there is a relationship between the bite of animal with the rabies incidence <em>(p value</em> 0.01) and OR = 5, there is a relationship between knowledge with the rabies incidence <em>(p value</em> 0.005) and OR = 8, there is a relationship between attitude with the rabies incidence <em>(p value</em> 0.004) with OR = 9.000, there is a relationship between preventive action with rabies incidence <em>(p value</em> 0.000) with OR = 3.Conclusions: factors that influencing rabies incidence are animals bite, knowledge, attitude, and preventive action. Suggestion: There should be held education promotion about rabies and monitoring of families who raise animals that can transmitted rabies in Puskesmas Rejosari by local health authorities</p><p> </p><p>Rabies merupakan penyakit yang disebabkan oleh virus. Rabies menyebabkan kematian. Berdasarkan data dari Dinas Kesehatan Kota Pekanbaru ditemukan bahwa kasus rabies tertinggi berada di Wilayah Kerja Puskesmas Rejosari yaitu sebanyak 15 kasus. Tujuan dari penelitian ini adalah untuk mengetahui faktor-faktor apa yang mempengaruhi kejadian di Wilayah Kerja Puskesmas Rejosari. Penelitian ini bersifat kuantitatif analitik dengan desain penelitian kasus kendali<em>. </em>Jumlah responden adalah 30 orang, terbagi dalam 15 orang kasus rabies dan 15 orang sebagai kendali. Analisa data menggunakan analisa univariat dan bivariate dengan uji <em>chi square</em>. Hasil penelitian mendapatkan bahwa terdapat hubungan antara gigitan hewan dengan kejadian penyakit rabies (<em>p value</em> 0.01) dengan OR = 5, terdapat hubungan antara pengetahuan dengan kejadian penyakit rabies (<em>p value</em> 0.005) dengan OR = 8, terdapat hubungan antara sikap dengan kejadian penyakit rabies (<em>p value</em> 0.004) dengan OR = 9.000, terdapat hubungan antara tindakan pencegahan dengan kejadian penyakit rabies (<em>p value</em> 0.000) dengan OR = 3. Kesimpulan : Faktor yang berpengaruh dengan kejadian rabies di wilayah kerja Puskesmas Rejosari adalah gigitan hewan, pengetahuan, sikap, dan tindakan pencegahan. Saran : Sebaiknya diadakan penyuluhan mengenai penyakit rabies serta dilakukan pemantauan pada keluarga yang memelihara hewan penular penyakit rabies di Puskesmas Rejosari oleh petugas kesehatan setempat.</p>
ANALISIS PERJUANGAN PEREMPUAN TOKOH ITEUNG DALAM NOVEL SEPERTI DENDAM, RINDU HARUS DIBAYAR TUNTAS KARYA EKA KURNIAWAN
Authors: Wijayanti Eka , Sugiarti Sugiarti 
Published: May 2019

Penelitian ini menyajikan tentang representasi sikap tokoh Iteung dengan menggunakan pendekatan psikologi sastra. Tujuan penelitian ini untuk mendiskripsikan (1) bentuk perjuangan tokoh dalam mewujudkan hak-hak perempuan; (2) bentuk pengungkapan hak-hak perempuan. Teori yang digunakan dalam penelitian ini adalah teori Feminis Julia Kristeva tentang hubungan kesetaraan gender terhadap perempuan. Pendekatan pada penilitian ini adalah pendekatan psikologis sastra yang memberikan perhatian pada masalah kejiwaan tokoh dalam sastra. Metode yang digunakan berupa deskriptif analisis untuk mendeskripsikan perjuangan perempuan dalam memperjuangkan hak-hak perempuan. Terdapat beberapa langkah untuk meneliti novel karya Eka Kurniawan berdasarkan topik yaitu pengumpulan data yang berasal dari monolog dan dialog yang menceritakan tokoh Iteung. Tahap selanjutnya yaitu mengolah data-data yang telah terkumpul dan dikaitkan dengan masalah yang akan dianalisis dan tahap selanjutnya menganalisis terkait permasalahan yang akan dianalisis, berupa (1) membaca, (2) mengidentifikasi data (3) mengelompokkan data sesuai dengan kajian. Hasil penelitian ini berupa kajian tentang beberapa hal. Pertama,bentuk perjuangan seorang perempuan berupa kesetaraan gender dan hak-hak berpendapat pada seorag perempuan. Kedua, bentuk ungkapan hak perempuan berupa perlawan serta pembelaan. Hubungan keduanya merupakan fitrah perempuan sebagai pemerjuang.Kata Kunci : Tokoh Iteung, feminis, psikologi sastra.