bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling user responses to AI-powered personalised recommendations: a qualitative study of consumer engagement dynamics on Douyin
Authors: Ding Liang , Antonucci Gianluca , Venditti Michelina 
Published: December 2024

Purpose
This study aims to explore the impact of artificial intelligence-powered personalised recommendations (AI-PPRs) on user engagement, browsing behaviour and purchase intentions on TikTok (Douyin in China), focusing on how these recommendations affect user satisfaction and purchase intention, while also addressing potential privacy concerns. In addition, the research investigates the influence of AI-recommended product presentation, timing and placement, as well as social factors such as key opinion leaders’ (KOLs) influence on consumer decision-making.

Design/methodology/approach
Using the expectancy-value theory and the stimulus-organism-response model, this research used a qualitative methodology through interviews with Douyin users to explore their experiences and perceptions of AI-PPRs.

Findings
The findings indicate that Douyin’s proactive “push” mechanism of AI-PPRs enhances user engagement by effortlessly integrating product discovery into the entertainment experience. Content-driven AI-PPRs align with user preferences, decrease search time and increase satisfaction and purchase intentions through engaging short videos and live streaming. However, privacy concerns emerge when personalisation is perceived as excessively intrusive, leading to negative emotions and avoidance behaviours. Recommendation timing and cultural context significantly influence receptiveness, with inappropriate timing (e.g. during holidays) causing negative reactions. Technical challenges, such as network issues during live streaming, negatively impact user experience and engagement. Content quality is crucial, and poor or irrelevant content leads to negative perceptions and disengagement. While KOLs face scepticism due to perceived commercialisation, endorsements from trusted figures and authentic influencers are better received. Innovative payment methods, like “Douyin Monthly Payment”, enhance financial flexibility and promote customer loyalty. This study highlights the need to balance personalisation with privacy, emphasising the importance of content quality and authenticity in influencer marketing. For businesses using AI-PPRs, maintaining this balance is essential for preserving trust and sustaining consumer engagement and loyalty.

Originality/value
This study contributes valuable insights to the field by unravelling the intricate dynamics between AI-PPRs, user preferences and social influences. The findings provide practical implications for companies aiming to optimise personalised recommendation algorithms and enhance user engagement, thereby facilitating business growth in the dynamic short video e-commerce market.
Digital transformation and talent management in industry 4.0: a systematic literature review and the future directions
Authors: Banerjee Pramit , Sharma Naman 
Published: December 2024

Purpose
This study aims to explore the relationship between digital transformation and talent management during the current industrial revolution (Industry 4.0). Talent management is a critical strategic focus for human resource (HR) managers, evolving with changing approaches over time. The paper seeks to guide talent management in Industry 4.0 by advocating a collaborative approach between employees and HR managers amidst technological transformations.

Design/methodology/approach
A systematic method of finding the literature using the PRISMA framework, through databases like Scopus, EBSCO, Emerald Insights and Science Direct was applied. A total of 629 papers were initially identified, which were filtered down to 42 papers for the review, leading to identification of research gaps, formulation of different research questions and proposal of a conceptual framework.

Findings
The literature highlights varied HR practices in Industry 4.0 and the corresponding transformation initiatives. It underscores that Industry 4.0 technologies empower employees to leverage creative, digital and interpersonal skills, fostering continuous learning. HR managers, through coaching and a commitment to sustainable practices, further motivate employees to acquire new skills. This collaborative effort propels the digital transformation of talent management, significantly impacting the overall talent pool.

Research limitations/implications
Although the literature review was conducted using prominent databases, some papers in regional languages were excluded, along with few articles whose full texts were not available, which may be a limitation of this paper.

Originality/value
This research represents a pioneering exploration of the interdisciplinary intersections between talent management and technological transformations. Initially, it surveys digital transformation practices, followed by a systematic review presenting various authors’ perspectives on talent management in Industry 4.0. The paper concludes by identifying research gaps and articulating key variables shaped by the intentions of HR managers and employees, thus, driving the transformation of talent.
Measuring overall functional diversity by aggregating its multiple facets: Functional richness, biomass evenness, trait evenness and dispersion
Authors: Wojcik Laurie Anne , Gaedke Ursula , van Velzen Ellen , Klauschies Toni 
Published: December 2024

Abstract

Human activities induce environmental changes, which can affect individuals' traits thereby leading to changes in functional diversity and finally in ecosystem functioning. Measuring functional diversity is thus of utmost importance to understand the consequences of such activities on ecosystem functioning. Functional diversity is composed of several facets, but these facets are almost always measured individually, and we lack a common metric integrating the multifaceted nature of functional diversity.

Consequently, we developed an index defined as the geometric mean of four independent facets: functional richness (the classic measure of the coverage of the trait axis), biomass evenness and trait evenness (quantifying how evenly distributed the biomass and traits are among species and within the feasible trait range, respectively) and dispersion (quantifying the spread around the biomass‐weighted mean trait). and each of its underlying facet take values between 0 and 1, and they assume the uniform distribution to yield maximal diversity.

We compared to other, more classic metrics measuring fewer facets of functional diversity by calculating all these indices for randomly and non‐randomly generated communities. We showed that overcomes several limitations of other indices (e.g. lack of accuracy, not computable for simple communities, unclear ecological interpretation) and is strongly correlated with ecosystem functions in simulated predator–prey communities. In addition, decomposing into its underlying facets revealed that ecosystem functions can be driven by different facets of on different trophic levels.

The strength of our index lies in being the only index that measures accurately the overall functional diversity by combining several facets and providing the option to decompose into them. This notably yields mechanistic insights about which facets are more important for driving changes in functional diversity and ecosystem functioning.
Beyond pathology: Patient experiences of laparoscopy for persistent pelvic pain with no identifiable cause found
Authors: McCaughey Tristan , Younes Melissa M , Raoofi Mooska , Hicks Lauren , Amir Michal , Reddington Charlotte , Cheng Claudia , Healey Martin , Peate Michelle 
Published: December 2024

BackgroundLaparoscopy has often been considered a core part of the workup for pelvic pain. However, many of these laparoscopies find no pathology.AimsTo evaluate the experiences of patients following laparoscopy for pelvic pain when there is no diagnosis found.Materials and MethodsThis descriptive qualitative study reviewed patients who underwent a diagnostic laparoscopy for persistent pelvic pain with no pathology found. Participants completed a written questionnaire and an in‐depth semi‐structured interview. Interview data were thematically analysed.ResultsFifteen patients were interviewed with a median age of 30 years. Six themes were identified: desire for a diagnosis, hope as a coping strategy, inadequate communication, having ‘next steps’ of management offered, mental health impacts, and system issues. Participants wanted a diagnosis to help understand their condition, to enable connection with others, and believed that clinicians viewed pain with a diagnosis more seriously. Participants who were confident preoperatively that laparoscopy would lead to a diagnosis reported this contributing to poorer postoperative mental health. Participants discussed diagnoses not listed in the medical records, which provided hope for future management options. Participants reported worse mental health following the laparoscopy.ConclusionThis study provides insight into the experiences of patients following a laparoscopy without an identifiable diagnosis. It highlights the importance of pre‐ and postoperative counselling, including discussing the potential for no findings at laparoscopy; the language used around other potential diagnoses; and the value in considering a patient's pre‐existing mental health. The findings of this study are relevant for all clinicians counselling people with persistent pelvic pain where endometriosis is suspected.
The sitting men: A systematic review of spare and working time exposure to sedentariness in relation to semen parameters
Authors: Sterpi Vittoria , Ricci Elena , Chiaffarino Francesca , Fedele Francesco , Esposito Giovanna , Parazzini Fabio , Viganò Paola , Cipriani Sonia 
Published: December 2024

AbstractBackgroundOver the past few decades, several studies have found that semen quality parameters have steadily declined over time. Many hypotheses have been made to explain this finding, among which a sedentary lifestyle has been investigated. To synthesize the current evidence, we performed a systematic review of published papers reporting on the relationship between sedentary habits and semen parameters.MethodsEmbase and PubMed were systematically searched for papers published in English up to May 2023. We included all full‐text observational papers that reported the relationship between sedentariness and semen parameters. Article selection adhered to the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guidelines.ResultsSixteen observational studies were ultimately included, six in healthy men and ten in men from Fertility Clinics. They encompassed a total of 13,509 men, with 9877 being healthy men and 3632 presenting at Fertility Clinics for initial assessment. In terms of semen volume, no association emerged in the six studies involving healthy men: however, results in men referring to fertility clinics mainly showed no association, with one indicating a decline and one higher volume. Twelve studies did not report differences in sperm concentration, while one study in men from Fertility Clinics and two in healthy men observed a decline in this parameter with increasing time spent on TV watching or sedentary posture in spare time. Total sperm count was found to be similar across groups of inactivity, except for one study that showed a significant decrease when men from Fertility Clinics spent more time watching TV. No significant differences were reported in sperm motility across all studies, with only one study, among those addressing sperm morphology, indicating a lower percentage of normal forms in men watching TV more than 3 h per day. Finally, three studies conducted in men referring to Fertility Clinics analyzed the sperm DNA fragmentation index. Two of these studies found a higher DNA fragmentation index in men spending more time per day in a sitting posture.ConclusionsThis review suggests a weak association between time spent sitting during spare time and sperm concentration, but the findings are inconsistent, highlighting the need for further research.
Nuclear lipids in chromatin regulation: Biological roles, experimental approaches and existing challenges
Authors: Sayed Ahmed , Eswara Karthik , Teles Kaian , Boudellioua Ahlem , Fischle Wolfgang 
Published: December 2024

AbstractLipids are crucial for various cellular functions. Besides the storage of energy equivalents, these include forming membrane bilayers and serving as signaling molecules. While significant progress has been made in the comprehension of the molecular and cellular biology of lipids, their functions in the cell nucleus remain poorly understood. The main role of the eukaryotic cell nucleus is to provide an environment for the storage and regulation of chromatin which is a complex of DNA, histones, and associated proteins. Recent studies suggest that nuclear lipids play a role in chromatin regulation and epigenetics. Here, we discuss various experimental methods in lipid‐chromatin research, including biophysical, structural, and cell biology approaches, pointing out their strengths and weaknesses. We take the view that nuclear lipids have a far more widespread impact on chromatin than is currently acknowledged. This gap in comprehension is mostly due to existing experimental challenges in the study of lipid‐chromatin biology. Several new, interdisciplinary approaches are discussed that could aid in elucidating the roles of nuclear lipids in chromatin regulation and gene expression.
Impact and Mechanisms of Action of BDNF on Neurological Disorders, Cancer, and Cardiovascular Diseases
Authors: Lei Min , Liu Qiwen , Nie Jinxia , Huang Rongyi , Mei Yan , Pan Dan , Chen Yong , Liu Wu 
Published: December 2024

ABSTRACTBrain‐derived neurotrophic factor (BDNF), which is primarily expressed in the brain and nervous tissues, is the most abundant neurotrophic factor in the adult brain. BDNF serves not only as a major neurotrophic signaling agent in the human body but also as a crucial neuromodulator. Widely distributed throughout the central nervous system (CNS), both BDNF and its receptors play a significant role in promoting neuronal survival and growth, thereby exerting neuroprotective effects. It is further considered as a guiding medium for the functionality and structural plasticity of the CNS. Increasingly, research has indicated the critical importance of BDNF in understanding human diseases. Activation of intracellular signaling pathways such as the mitogen‐activated protein kinase pathway, phosphatidylinositol 3‐kinase/protein kinase B/mammalian target of rapamycin pathway, and phospholipase C γ pathway by BDNF can all potentially enhance the growth, survival, proliferation, and migration of cancer cells, influencing cancer development. The loss of BDNF and its receptor, tropomyosin receptor kinase B, in signaling pathways is also associated with increased susceptibility to brain and heart diseases. Additionally, reduced BDNF levels in both the central and peripheral systems have been closely linked to various neurogenic diseases, including neuropathic pain and psychiatric disorders. As such, this review summarizes and analyzes the impact of BDNF on neurogenic diseases, cancer, and cardiovascular diseases. This study thereby aimed to elucidate its effects on these diseases to provide new insights and approaches for their treatment.
Influence of Donor Transfusion on Heart Transplantation Outcomes: A United Network for Organ Sharing Registry Analysis
Authors: Tavolacci Sooyun Caroline , Gregory Vasiliki , Okumura Kenji , Isath Ameesh , Shimamura Junichi , Spielvogel David , Ohira Suguru 
Published: December 2024

ABSTRACTIntroductionThere is a lack of evidence regarding the impact of donor blood transfusion on heart transplant (HT) outcomes. We sought to elucidate the influence of donor transfusion on HT outcomes using the national database.MethodsFrom January 2004 to March 2023, donor transfusion information was available for 40 538 recipients for HT in the United Network for Organ Sharing (UNOS) database. We used the UNOS 4‐level designation of transfusion (no blood [N = 18 575], 1–5 units [N = 14 098], 6–10 units [N = 4766], and massive transfusion of > 10 units [N = 3099]).ResultsAmong this cohort, 53.2% of donors (N = 20 220) received a blood transfusion during the same admission. Donors who required blood transfusion commonly had head trauma as a cause of death (no‐blood, 22% vs. 1–5 units, 61%, 6–10 units, 88%, massive, 89%, p < 0.001). An increased amount of donor blood transfusion did not affect rates of acute rejection (no‐blood, 18% vs. 1–5 units, 19%, 6–10 units, 17%, massive, 19%, p = 0.13). The number of units transfused also did not affect 1‐year survival rates. The Cox hazard model showed no effect of massive transfusion on mortality following transplant (no‐blood, reference vs. 1–5 units; HR, 1.02 [p = 0.35], 6–10 units; HR, 1.10 [p = 0.01], massive transfusion; HR 1.04 [p = 0.3]).ConclusionsMassive transfusion in donors was not associated with increased recipient mortality. Additionally, the amount of donor blood transfusion did not affect rejection rates following HT. The present study suggests that a history of donor blood transfusion, as well as the amount of transfusion, should not preclude donor heart utilization.
Translational findings support regimen selection for first‐in‐human study of ubamatamab (MUC16 × CD3 bispecific antibody) in patients with recurrent ovarian cancer
Authors: Zhu Min , Madia Priyanka , Crawford Alison , Brouwer‐Visser Jurriaan , Krueger Pamela , Haber Lauric , Peterman Mary , Uldrick Thomas S. , Miller Elizabeth , Davis John D. , Retter Marc W. 
Published: December 2024

AbstractUbamatamab, a Mucin 16 (MUC16) × cluster of differentiation 3 (CD3) bispecific antibody that promotes T‐cell‐mediated cytotoxicity of MUC16‐expressing cells, is being investigated for the treatment of ovarian cancer. Intravenous administration of ubamatamab, with or without the anti‐programmed cell death‐1 inhibitor cemiplimab, is being evaluated in a first‐in‐human study in patients with recurrent ovarian cancer. In vitro cytotoxicity and cytokine data and projected ubamatamab human pharmacokinetic (PK) profiles scaled with monkey PK parameters enabled starting‐dose selection in humans. Mouse tumor regression studies identified ubamatamab effective concentrations. Preclinical and clinical PK, cytokine, safety, and efficacy data from dose escalation were integrated to determine expansion regimens. A starting dose of 0.1 mg was selected, which showed acceptable safety in patients. A step‐up dosing approach was used to effectively manage cytokine release syndrome. Mouse tumor regression models suggested an ubamatamab efficacious concentration range of 0.4–50 mg/L, consistent with clinical activity observed at ubamatamab trough concentrations ≥5 mg/L. Integrating preclinical and clinical data determined a target trough concentration range of 5–30 mg/L, which supports evaluation of ubamatamab 250 mg with or without cemiplimab and 800 mg monotherapy once every 3 weeks in expansion cohorts. Preclinical data (cytokine release, tumor regression, monkey PK) had translational value in supporting regimen selection in dose escalation and subsequently in dose expansion after integration with patient data from dose escalation.
Establishment size and the task content of jobs: evidence from 46 countries
Authors: De Vera Micole , Garcia‐Brazales Javier 
Published: December 2024

AbstractUsing a mix of household‐ and employer‐based survey data from 46 countries, we provide novel evidence that workers in larger establishments perform more non‐routine analytical tasks, even within narrowly defined occupations. Moreover, workers in larger establishments rely more on the use of information and communication technologies to perform these tasks. We also document a 15% raw wage premium that workers in larger establishments enjoy relative to their counterparts in smaller establishments. A mediation analysis shows that our novel empirical facts on the task content of jobs are able to explain 5–20% of the establishment size wage premium, a similar fraction to what can be explained by selection of workers on education, gender and age.
Can Thinning Foster Forest Genetic Adaptation to Drought? A Demo‐Genetic Modelling Approach With Disturbance Regimes
Authors: Fririon Victor , Davi Hendrik , Oddou‐Muratorio Sylvie , Ligot Gauthier , Lefèvre François 
Published: December 2024

ABSTRACTIn managed populations—whether for production or conservation—management practices can interfere with natural eco‐evolutionary processes, providing opportunities to mitigate immediate impacts of disturbances or enhance selection on tolerance traits. Here, we used a modelling approach to explore the interplay and feedback loops among drought regimes, natural selection and tree thinning in naturally regenerated monospecific forests. We conducted a simulation experiment spanning three nonoverlapping generations with the individual‐based demo‐genetic model Luberon2. Luberon2 integrates forest dynamics processes driving survival and mating success, including tree growth, competition, drought impacts and regeneration, with genetic variation in quantitative traits related to these processes. We focused on two variable traits: individual vigour, determining diameter growth potential without stress as the deviation from average stand growth, and individual sensitivity to drought stress as the slope of the relationship between diameter growth and drought stress level. We simulated simplified thinning scenarios, tailored to even‐aged stands. Considering plausible genetic variation and contrasting drought regimes, the predicted evolutionary rates for both traits aligned with documented rates in wild plant and animal populations. Thinning considerably reduced natural selective pressures caused by competition and drought compared to unthinned stands. However, the conventional thinning practice of retaining the larger trees resulted in indirect anthropogenic selection that enhanced genetic gain in vigour and lowered sensitivity by up to 30%. More intensive thinning aimed at reducing drought stress by reducing stand density hampered the selection against sensitivity to drought, potentially hindering long‐term adaptation. Conversely, avoiding the early, nonselective thinning step—thereby promoting both natural and anthropogenic selection—ultimately resulted in better stand performance while maintaining long‐term evolvability. This study emphasises the potential of evolution‐oriented forestry strategies to combine drought stress mitigation with genetic adaptation. It provides general insights into how population management, disturbance regimes and eco‐evolutionary responses interfere, aiding sustainable decision‐making amid environmental uncertainties.