bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corvus Corax: medieval rock, the minstrel, and cosmopolitanism as anti-nationalism
Authors: Yri Kirsten 
Published: October 2019

AbstractThis article explores the German band Corvus Corax and their reinterpretion of the Middle Ages as a creative answer to Germany's problematic history of nationalism. Invoking the community ideals and ideological values of the 1960s and 1970s, which, in the context of the GDR took on even more significance, Corvus Corax borrowed ‘authentic’ medieval texts and melodies, rendering them in acoustic arrangements inspired by medieval performance practices. In short, German ‘folk’ bands invented ‘medieval’ rock to sidestep Nazi connotations with the word ‘folk’. Besides invoking the semantic shift from ‘folk’ to ‘medieval’, I argue that the band adopts the figure of the medieval minstrel and asserts that his multilingual texts, ‘foreign’ instruments and colourful performance practices speak to an inclusive, diverse and cosmopolitan community. Paradoxically, they do so by first positioning the medieval minstrel as a punked-up, marginalised ‘outcast’. The cultural capital of this outcast status helps medieval rock bands like Corvus Corax carve out a space for marginalised voices who, in their new privileged positions, offer a form of retribution for politics of exclusion, racism and authoritarianism.
Good things come in threes: triplet flow in recent hip-hop music
Authors: Duinker Ben 
Published: October 2019

AbstractMCs (rappers) such as Cardi B, Kendrick Lamar, Drake, Big Sean and Young Thug use triplet rhythms in their rapping, a practice that is known as triplet flow. This paper argues that the prevalence of triplet flow is one of the most aurally salient features of contemporary hip hop, and exemplifies the popularity and influence of the Atlanta-centred genre of trap music through its sparse, slow beats. Three types of triplet flow are defined – mixed, phrasal and total – and are used to explore how various songs and artists active in the late 1980s and early 1990s provided the stylistic blueprint for triplet flow's recent explosion in popularity. With the aid of a 50 song mini-corpus, the paper concludes with a general survey of stylistic characteristics common in many songs featuring triplet flow, and further analysis of two of these songs in order to illuminate the creative, rhetorical and virtuosic potential that underpins this ostensibly simple style of rapping.
Extrafloral nectar as a driver of ant community spatial structure along disturbance and rainfall gradients in Brazilian dry forest
Authors: da Silva Carlos Henrique Félix , Arnan Xavier , Andersen Alan N. , Leal Inara R. 
Published: October 2019

AbstractAlthough extrafloral nectar (EFN) is a key food resource for arboreal ants, its role in structuring ground-nesting ant communities has received little attention, despite these ants also being frequent EFN-attendants. We investigated the role of EFN as a driver of the spatial structure of ground-nesting ant communities occurring in dry forest in north-eastern Brazil. We examined the effects on this relationship of two global drivers of biodiversity decline, chronic anthropogenic disturbance and climate change (through decreasing rainfall). We mapped EFN-producing plants and ant nests in 20 plots distributed along independent gradients of disturbance and rainfall. We categorized ant species into three types according to their dependence on EFN: heavy users, occasional users and non-users. We found a strong relationship between ant dependence on EFN and nest proximity to EFN-producing plants: heavy-users (mean distance 1.1 m) nested closer to EFN-producing plants than did occasional users (1.7 m), which in turn nested closer to EFN-producing plants than did non-users (2.3 m). Neither disturbance nor rainfall affected the proximity of heavy-user nests to EFN-producing plants. Our study shows for the first time that EFN is a key driver of the spatial structure of entire communities of ground-nesting ants.
Liturgy and chant in a twelfth-century Exeter missal
Authors: MANNION ANNE 
Published: October 2019

AbstractExeter Cathedral Library and Archives MS 3515 (hereafter EXcl 3515), a notated missal located in Exeter Cathedral, has to date received very little scholarly attention. This neglect may be due to the absence of a liturgical kalendar and evidence of local saints in the Sanctorale. Its assignment to the thirteenth century with a generic English origin suggests that critical questions concerning provenance and dating have been overlooked. The source itself comprises four disparate sections assembled so as to create a complete liturgical cycle. Yet the parts are not as separate as hitherto believed. A comparative investigation reveals not only an Exeter provenance and a twelfth-century dating, but also a new witness to the St Denis/Corbie tradition. Research also reveals unexpected threads of liturgical continuity with the Anglo-Saxon past. As a complete pre-Sarum source of Mass prayers, chants and readings, EXcl 3515 offers a useful lens with which to view a transitional period in the development of a medieval secular liturgy in England. (By contrast, the three dominant cathedrals – Salisbury, York and Hereford – all lack notated chant sources from this period.) EXcl 3515 adds not only significant new data to the current information on secular liturgies, but also challenges accepted theories on the shaping of a distinctive English Use in southwest England.
Sperm DNA fragmentation: causes and identification
Authors: Hamilton Thais Rose dos Santos , Assumpção Mayra Elena Ortiz D’Ávila 
Published: October 2019

SummarySperm DNA fragmentation is referred to as one of the main causes of male infertility. Failures in the protamination process, apoptosis and action of reactive oxygen species (ROS) are considered the most important causes of DNA fragmentation. Action of ROS or changes in sperm protamination would increase the susceptibility of sperm DNA to fragmentation. Routine semen analysis is unable to estimate sperm chromatin damage. Sperm DNA integrity influences sperm functional capability, therefore tests that measure sperm DNA fragmentation are important to assess fertility disorders. Actually, there is a considerable number of methods for assessing sperm DNA fragmentation and chromatin integrity, sperm chromatin stability assay (SCSA modified), sperm chromatin dispersion (SCD), comet assay, transferase dUTP nick end labelling (TUNEL); and protamine evaluation in sperm chromatin assay, such as toluidine blue, CMA3, protamine expression and evaluation of cysteine radicals. This review aims to describe the main causes of sperm DNA fragmentation and the tests commonly used to evaluate sperm DNA fragmentation.
Poverty-environment relationships under market heterogeneity: cash transfers and rural livelihoods in Zambia
Authors: Lawlor Kathleen , Handa Sudhanshu , Davis Benjamin , Seidenfeld David ,   the Zambia Cash Transfer Evaluation Team
Published: October 2019

AbstractWe examine the environmental impacts of a cash transfer program in rural Zambia and investigate whether variation in market access is associated with heterogeneous impacts on natural resource use. We consider households’ use of firewood, charcoal, bushmeat and land for farming, as well as their ownership of non-farm businesses. We find that cash transfers increase the likelihood of charcoal consumption as well as the amount consumed for those living close to paved roads. The transfers also enable households to increase the size of their farms and establish non-farm businesses. These impacts are most pronounced for those living far from paved roads. While remoteness is associated with farm expansion in response to the cash transfer, more education causes those receiving the transfer to decrease the size of their farms. This impact heterogeneity has important implications for sustainable development.
RC-POSITIVITY, VANISHING THEOREMS AND RIGIDITY OF HOLOMORPHIC MAPS
Authors: Yang Xiaokui 
Published: October 2019

AbstractLet $M$ and $N$ be two compact complex manifolds. We show that if the tautological line bundle ${\mathcal{O}}_{T_{M}^{\ast }}(1)$ is not pseudo-effective and ${\mathcal{O}}_{T_{N}^{\ast }}(1)$ is nef, then there is no non-constant holomorphic map from $M$ to $N$. In particular, we prove that any holomorphic map from a compact complex manifold $M$ with RC-positive tangent bundle to a compact complex manifold $N$ with nef cotangent bundle must be a constant map. As an application, we obtain that there is no non-constant holomorphic map from a compact Hermitian manifold with positive holomorphic sectional curvature to a Hermitian manifold with non-positive holomorphic bisectional curvature.
Expression of cholesterol packaging and transport genes in human and rat placenta: impact of obesity and a high-fat diet
Authors: Draycott Sally A. V. , Daniel Zoe , Khan Raheela , Muhlhausler Beverly S. , Elmes Matthew J. , Langley-Evans Simon C. 
Published: October 2019

AbstractEvidence suggests that sub-optimal maternal nutrition has implications for the developing offspring. We have previously shown that exposure to a low-protein diet during gestation was associated with upregulation of genes associated with cholesterol transport and packaging within the placenta. This study aimed to elucidate the effect of altering maternal dietary linoleic acid (LA; omega-6) to alpha-linolenic acid (ALA; omega-6) ratios as well as total fat content on placental expression of genes associated with cholesterol transport. The potential for maternal body mass index (BMI) to be associated with expression of these genes in human placental samples was also evaluated. Placentas were collected from 24 Wistar rats at 20-day gestation (term = 21–22-day gestation) that had been fed one of four diets containing varying fatty acid compositions during pregnancy, and from 62 women at the time of delivery. Expression of 14 placental genes associated with cholesterol packaging and transfer was assessed in rodent and human samples by quantitative real time polymerase chain reaction. In rats, placental mRNA expression of ApoA2, ApoC2, Cubn, Fgg, Mttp and Ttr was significantly elevated (3–30 fold) in animals fed a high LA (36% fat) diet, suggesting increased cholesterol transport across the placenta in this group. In women, maternal BMI was associated with fewer inconsistent alterations in gene expression. In summary, sub-optimal maternal nutrition is associated with alterations in the expression of genes associated with cholesterol transport in a rat model. This may contribute to altered fetal development and potentially programme disease risk in later life. Further investigation of human placenta in response to specific dietary interventions is required.
Canopy and Terrain Interactions Affecting Snowpack Spatial Patterns in the Sierra Nevada of California
Authors: Zheng Zeshi , Ma Qin , Jin Shichao , Su Yanjun , Guo Qinghua , Bales Roger C. 
Published: October 2019

AbstractAirborne light detection and ranging is an emerging measurement tool for snowpack estimation, and data are now emerging to better assess multiscale snow depth patterns. We used airborne light detection and ranging measurements from four sites in the southern Sierra Nevada to determine how snow depth varies with canopy structure and the interactions between canopies and terrain. We processed the point clouds into snow depth rasters at 0.5×0.5‐m2 resolution and performed statistical analysis on the processed snow depth data, terrain attributes, and vegetation attributes, including the individual tree bole locations, canopy crown area, and canopy height. We studied the snow depth at such a fine scale due in part to the spatial heterogeneity introduced by canopy interception and enhanced melting caused by tree trunks in forested areas. We found that the dominant direction of a tree well, the area around the tree bole that has shallower snowpack, is correlated with the local aspect of the terrain, and the gradient of the snow surface in a tree well is correlated with the tree's crown area. The regression‐tree based XGBoost model was fitted with the topographic variables and canopy variables, and about 71% of snow depth variability can be explained by the model.
Why Is Crustal Underplating Beneath Many Hot Spot Islands Anisotropic?
Authors: Park Jeffrey , Rye Danny M. 
Published: October 2019

AbstractHigh‐frequency harmonic regression (2.0–4.0‐Hz cutoff) of receiver functions at two long‐running seismic observatories at mid‐Pacific hot spot islands confirms earlier detections of underplated material with seismic velocities intermediate to crust and mantle, and reveals it to be multilayered and anisotropic within ~30 km of the surface. Magmatic underplating beneath the oceanic Moho has been proposed to accompany basaltic melt that erupts at the seafloor and (eventually) atop a subaerial volcano. An alternate hypothesis is “metasomatic underplating” whereby crustal fractures developed during magma ascent allow seawater to infiltrate and to serpentinize the sub‐Moho mantle partially. Metasomatic underplating would lower seismic wave speeds, promote the buoyancy of the hot spot swell, and induce textural anisotropy as metamorphic expansion of olivine‐rich peridotite promotes a crack network along which serpentinization spreads. Differential expansion of mantle peridotite and crustal gabbro promotes cracks in the crust that offer new pathways for seawater to descend to the Moho, allowing metasomatic underplating to expand laterally and to contribute anisotropy to the underplated layer. Rare serpentinized mantle xenoliths confirm that crack textures can develop during serpentinization at depth. The discovery of iron‐oxidizing microbial mats on the seafloor flank of the Loihi volcano, and many locations of diffuse low‐temperature venting worldwide, is consistent with the circulation of metasomatic fluids with reducing chemistry, sourced from serpentinization at depth. Posteruptive uplift of Santa Maria Island (Azores), and asymmetry of the Hawaiian swell, suggests that underplating requires 2–4 Myr to complete, suggesting that fluid infiltration is slow, subject to cycles of blockage and fresh fracturing.
Saturn's Plasmapause: Signature of Magnetospheric Dynamics
Authors: Thomsen M.F. , Coates A.J. 
Published: October 2019

AbstractWe explore the paradigm that Saturn's plasmapause marks the boundary between the magnetic flux tubes that have been circulating around the planet for some time, accumulating a dense load of Enceladus‐sourced material, and those that have recently undergone tail reconnection, shedding the bulk of the cold plasma and retaining a more tenuous, heated population. A centrifugally driven interchange instability should develop at this boundary, producing fingers of outward propagating dense plasma and of inward propagating hot, tenuous plasma. The plasmapause should thus be identifiable as a transition from mostly‐dense‐with‐some‐tenuous to mostly‐tenuous‐with‐some‐dense plasma populations. Electron densities from the Cassini Plasma Spectrometer/Electron Spectrometer (CAPS/ELS) instrument are used to identify the location of this transition for all of the low‐latitude (<5° from the magnetic equator) passes through Saturn's inner/middle magnetosphere. The boundary is typically found near and somewhat beyond L=10 (i.e., at ~10 Rs from the planet), with a local time asymmetry such that it is closer to the planet on the night side than on the day side.
Spatially Extensive Ground‐Penetrating Radar Snow Depth Observations During NASA's 2017 SnowEx Campaign: Comparison With In Situ, Airborne, and Satellite Observations
Authors: McGrath Daniel , Webb Ryan , Shean David , Bonnell Randall , Marshall Hans‐Peter , Painter Thomas H. , Molotch Noah P. , Elder Kelly , Hiemstra Christopher , Brucker Ludovic 
Published: October 2019

AbstractSeasonal snow is an important component of Earth's hydrologic cycle and climate system, yet it remains challenging to consistently and accurately measure snow depth and snow water equivalent (SWE) across the range of diverse snowpack conditions that exist on Earth. The NASA SnowEx campaign is focused on addressing the primary gaps in snow remote sensing in order to gain an improved spatiotemporal understanding of this important resource and to further efforts toward a future satellite‐based snow remote sensing mission. Ground‐penetrating radar (GPR) is an efficient and mature approach for measuring snow depth and SWE. We collected ~1.3 million GPR snow depth observations during the NASA SnowEx 2017 campaign, yielding a spatially extensive (~133‐km total length) and high‐resolution (~10‐cm lateral spacing) validation data set to assess various remote sensing and modeling approaches. We found high correlation between the GPR and manual snow probe derived snow depths (r = 0.89, p < 0.0001, root‐mean‐square error (RMSE) = 18 cm), but a median difference of −10 cm, which we attribute, in part, to probe penetration into the unfrozen subsurface. We also compared GPR‐derived snow depths to two other independent estimates of snow depth, as an example of how this data set can be used for validation of remote sensing techniques: Airborne Snow Observatory lidar‐derived snow depths (r = 0.90, p < 0.0001, median difference = −1 cm, RMSE = 14 cm) and preliminary DigitalGlobe WorldView‐3 satellite‐derived snow depths (r = 0.70, p < 0.0001, median difference = −3 cm, RMSE = 24 cm).
PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1
Authors: Ji Jianxiong , Ding Kaikai , Luo Tao , Xu Ran , Zhang Xin , Huang Bin , Chen Anjing , Zhang Di , Miletic Hrvoje , Bjerkvig Rolf , Thorsen Frits , Wang Jian , Li Xingang 
Published: October 2019

Abstract
The Hippo signaling pathway controls organ development and is also known, in cancer, to have a tumor suppressing role. Within the Hippo pathway, we here demonstrate, in human gliomas, a functional interaction of a transmembrane protein, prostate transmembrane protein, androgen induced 1 (PMEPA1) with large tumor suppressor kinase 1 (LATS1). We show that PMEPA1 is upregulated in primary human gliomas. The PMEPA1 isoform PMEPA1a was predominantly expressed in glioma specimens and cell lines, and ectopic expression of the protein promoted glioma growth and invasion in vitro and in an orthotopic xenograft model in nude mice. In co-immunoprecipitation experiments, PMEPA1a associated with the Hippo tumor suppressor kinase LATS1. This interaction led to a proteasomal degradation of LATS1 through recruitment of the ubiquitin ligase, neural precursor cell expressed, developmentally downregulated 4 (NEDD4), which led to silencing of Hippo signaling. Alanine substitution in PMEPA1a at PY motifs resulted in failed LATS1 degradation. Targeting of a downstream component in the Hippo signaling pathway, YAP, with shRNA, interfered with the growth promoting activities of PMEPA1a in vitro and in vivo. In conclusion, the presented work shows that PMEPA1a contributes to glioma progression by a dysregulation of the Hippo signaling pathway and thus represents a promising target for the treatment of gliomas.
The rostroventral part of the thalamic reticular nucleus modulates fear extinction
Authors: Lee Joon-Hyuk , Latchoumane Charles-Francois V. , Park Jungjoon , Kim Jinhyun , Jeong Jaeseung , Lee Kwang-Hyung , Shin Hee-Sup 
Published: October 2019

AbstractThe thalamus has been implicated in fear extinction, yet the role of the thalamic reticular nucleus (TRN) in this process remains unclear. Here, in mice, we show that the rostroventral part of the TRN (TRNrv) is critically involved in the extinction of tone-dependent fear memory. Optogenetic excitation of TRNrv neurons during extinction learning dramatically facilitated, whereas the inhibition disrupted, the fear extinction. Single unit recordings demonstrated that TRNrv neurons selectively respond to conditioned stimuli but not to neutral stimuli. TRNrv neurons suppressed the spiking activity of the medial part of the dorsal midline thalamus (dMTm), and a blockade of this inhibitory pathway disrupted fear extinction. Finally, we found that the suppression of dMTm projections to the central amygdala promotes fear extinction, and TRNrv neurons have direct connections to this pathway. Our results uncover a previously unknown function of the TRN and delineate the neural circuit for thalamic control of fear memory.
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype
Authors: Cai Demin , Wang Junjian , Gao Bei , Li Jin , Wu Feng , Zou June X. , Xu Jianzhen , Jiang Yuqian , Zou Hongye , Huang Zenghong , Borowsky Alexander D. , Bold Richard J. , Lara Primo N. , Li Jian Jian , Chen Xinbin , Lam Kit S. , To Ka-Fai , Kung Hsing-Jien , Fiehn Oliver , Zhao Ruqian , Evans Ronald M. , Chen Hong-Wu 
Published: October 2019

AbstractTumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear receptor RORγ, compared to estrogen receptor-positive breast cancer. Genetic and pharmacological inhibition of RORγ reduces tumor cholesterol content and synthesis rate while preserving host cholesterol homeostasis. We demonstrate that RORγ functions as an essential activator of the entire cholesterol-biosynthesis program, dominating SREBP2 via its binding to cholesterol-biosynthesis genes and its facilitation of the recruitment of SREBP2. RORγ inhibition disrupts its association with SREBP2 and reduces chromatin acetylation at cholesterol-biosynthesis gene loci. RORγ antagonists cause tumor regression in patient-derived xenografts and immune-intact models. Their combination with cholesterol-lowering statins elicits superior anti-tumor synergy selectively in TNBC. Together, our study uncovers a master regulator of the cholesterol-biosynthesis program and an attractive target for TNBC.
Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide
Authors: Wu Lin-Ping , Ahmadvand Davoud , Su Junan , Hall Arnaldur , Tan Xiaolong , Farhangrazi Z. Shadi , Moghimi S. Moein 
Published: October 2019

AbstractThe filamentous bacteriophage fd bind a cell target with exquisite specificity through its few copies of display peptides, whereas nanoparticles functionalized with hundreds to thousands of synthetically generated phage display peptides exhibit variable and often-weak target binding. We hypothesise that some phage peptides in a hierarchical structure rather than in monomeric form recognise and bind their target. Here we show hierarchial forms of a brain-specific phage-derived peptide (herein as NanoLigand Carriers, NLCs) target cerebral endothelial cells through transferrin receptor and the receptor for advanced glycation-end products, cross the blood-brain-barrier and reach neurons and microglial cells. Through intravenous delivery of NLC-β-secretase 1 (BACE1) siRNA complexes we show effective BACE1 down-regulation in the brain without toxicity and inflammation. Therefore, NLCs act as safe multifunctional nanocarriers, overcome efficacy and specificity limitations in active targeting with nanoparticles bearing phage display peptides or cell-penetrating peptides and expand the receptor repertoire of the display peptide.