bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermittent vagus nerve stimulation allows preventing the “escape” effect of heart rhythm changes
Authors: Poleshchenko Ya. I. , Oleynikov D. A. , Lukichev V. Yu. , Khromikhin D. A. , Krylova M. A. , Sonin D. L. , Karpov A. A. , Shubina P. Yu. , Protsak E. S. , Lebedev D. S. , Galagudza M. M. , Minasian S. M. , Mikhaylov E. N. 
Published: January 2019

Background.Vagus nerve stimulation has been proposed for the treatment of a number of diseases. The positive effects of vagus nerve stimulation on ischemic and reperfusion myocardial injury has been tested in experimental models. However, the escape effect of vagus activation on heart rate and the methodology to overcome this effect have not been reported properly.Objective. The purpose of the study is to evaluate parameters of prolonged stimulation that decrease heart rate and allow overcoming the escape effect of vagus nerve activation.Design and methods. We used Wistar rats (n = 9). Cervical section was performed under general anesthesia. Left vagus nerve isolated from adjacent tissue was contacted with custom stimulation electrodes and a custom pulse generator. Blood pressure was measured in the right common carotid artery. Limb electrocardiogram was continuously recorded. First, stimulation parameters repeatedly evoking vagal reaction (decrease in heart rate) without nerve damage were evaluated. Second, parameters of intermittent stimulation that allowed repeat and consistent heart rate decrease were assessed.Results. During experiments, in 5 animals the following parameters leading to sustained 30 ± 20 % heart rate reduction were found: rectangular pulse, 30 Hz, 0,5 ms, 1–2 V (0,6– 0,8 mA). Stimulation with 50 Hz frequency led to nerve damage in 1 case. Stimulation with 20 Hz frequency led to heart rate over-suppression of heart rate and blood pressure. Intermittent nerve stimulation was tested in 4 animals and led to repeated heart rate decrease by 38 ± 15 %. The parameters which helped to avoid escape effect on heart rate change were the following: the length of stimulation episode of 45 s and interruption of stimulation for 15 s.Conclusion. Intermittent electrical stimulation evokes vagal reactions on heart rate and allows overcoming the escape effect of vagal activation.
The decision support system in the treatment of arterial hypertension — control of the data entry into the electronic chart
Authors: Avdonina N. G. , Bolgova, E. V. , Ionov M. V. , Zvartau N. E. , Konradi A. O. 
Published: January 2019

Background.One of the key problems of keeping records in medical information systems is the correctness of the data entry. Even the simplest decision support systems (DSS) can be highly useful regarding the reduction in the number of errors in entering data and recommendations.Thepurposeof this study was to assess the effectiveness of the implementation of the simplest DSS, designed to minimize the number of input errors of the patient’s key characteristics and to implement a basic control for the recommendation section.Design and methods.DSS was developed as a data analysis system of a medical information system that can perform functions directly integrating into a working medical information system. The study involved 7 cardiologists of the counseling and diagnostic center of the Almazov National Medical Research Centre (St Petersburg, Russia), who tested the established DSS for 10 weeks as part of their daily work on counseling patients with arterial hypertension. Altogether 1280 records were analyzed in the main group and 1060 in the control group. Results.In the group with notifications enabled, the total number of errors in the same section comprised 49,1 %, while 84,7 % of them were recorded during the first week of using the system, and by the time of the visit only 8,7 % of the errors were registered. In the control group, the total number of errors was 63,7 %, while 42,2 % remained uncorrected. In the recommendation section, the number of errors was almost identical in both groups, 24 % in the group that worked in the “fixation” mode, and 25,5 % in the group with error notifications enabled. At the same time, in the latter one, at the end of the visit, 7 % errors remained uncorrected. In a detailed analysis of the data in the “physical examination” section, the largest number of missing data related to the anthropometric indicators, especially the waist circumference. When assessing the quality of input data, we found that the group with enabled notifications showed a progressive decrease in the number of errors and unfilled fields in the “physical examination” section.Conclusion.The use of the simplest DSS in the outpatient admission of patients with arterial hypertension can significantly improve the quality of the input of structured data necessary for patient risk stratification. It also contributes to the patient’s safety in terms of the correctness of the medical prescriptions.
KARAKTERISTIK SENSORI DAN FISIK KULIT PANGSIT GORENG DENGAN SUBSTITUSI TEPUNG YANG BERBEDA PADA PENYIMPANAN DINGIN DAN BEKU
Authors: Anugrahati Nuri Arum , Natania Natania , Andrew Andrew 
Published: January 2019

Wonton wrapper is a type of pasta that has a similar composition with noodle, such as wheat flour, water, egg, salt, and kansui. Indonesian people has also consumed wonton wrapper but it has been limited due to the difficulty of wheat flour supply as it’s main ingredient. To reduce the dependency of imported wheat flour, this experiment was held to determine tapioca, sago, and glutinous rice as a substitute to wheat flour. The aims of this research were to determine the type of flour to substitute wheat flour in fried wonton wrapper making, to determine the protein percentage of wheat flour in fried wonton wrapper making, and to determine the sensory and physical characteristics of wonton wrapper on cold and frozen storage. This research was conducted by RAL (completely randomized design) using two treatment factors are three kinds of flour (tapioca, sago, and glutinous rice) and three substitution level of concentration (15, 30, and 45%). The organoleptic result showed that fried wonton wrapper made from medium protein wheat flour with 30% tapioca flour substitution was the best treatment to produce a good quality since it had a higher crunchiness, acceptance, and substitution level. Sensory and physical characteristics of wonton wrapper has been maintained during 4 weeks of freezing storage.
Keywords: fried wonton wrapper, wheat flour, tapioca
VARIASI KOMPOSISI INPUT PROSES ANAEROBIK UNTUK PRODUKSI BIOGAS PADA PENANGANAN LIMBAH CAIR KOPI
Authors: Novita Elida , Wahyuningsih Sri , Pradana Hendra Andiananta 
Published: January 2019

Generally, there are two methods of coffee processing beans that are the dry processing and wet processing. The wet coffee processing will produce waste water containing organic materials. The high contain of organic matter in coffee wastewater can be used as biogas through anaerobic process. The biogas production from this processcould have variation of volume and composition depends on their feeding. The purposes of this research were to find the best biogas volume would be produced based on variation of input in batch feeding method (1) and to reduce coffee wastewater concentration by anaerobic process (2). The researched procedures were inoculum production, incubating adaptation and variation of batch feeding into the anaerobic reactor (4 variations). The variation of batch feeding were (1) 1:1; (2) 3:1; (3) 3.7:0.3 for water and (4) 3.6 : 0.4 for cow dung. The highest biogas volume and pollution load reduction were occurred in batch feeding composition 1:1. The volume of biogas production was 250 mL at day 6 and the percentage of parameters reduction were COD 57.35% and BOD 57%. Based on this research, there were also increasing gas volume from day 2 (95 ml) up to day 6 (250 ml) in each batch.
Keywords: anaerobic process, biogas, coffee wastewater treatment, input variation
SISTEM DINAMIS PENILAIAN KINERJA PRODUKSI TEH KEBUN BANTARAN PT PERKEBUNAN NUSANTARA XII
Authors: Brilliantina Aulia , Purnomo Bambang Herry , Suryaningrat Ida Bagus 
Published: January 2019

In the last ten years, the performance of Indonesia’s tea agroindustry has been decreased. It is shown by the decreasing of tea estate area as much as 2.18 percent per year, tea production decreased as much as 0.8 percent, and export volume decreased as much as 1,07 percent per year. This study were aimed to identify performance measurement results of tea production at Bantaran plantation area PT Perkebunan Nusantara XII based on the achievement of RKAP and evaluated the performance achieved through the production of tea agroindustry by dynamic system method. This method allowed to conduct comprehensive studies to study the behavior and improved system performance. This study was started from the observation, interviews, and document collection, which then was made causal loop diagram to the simulation model creation and validation of the model made. From the simulation, it came with conclusion, if there was no policy change, then Bantaran plantation area had a decreased performance status.
Keywords: tea production, dynamic system, performance measurement
ANALISIS EFISIENSI BIAYA PERSEDIAAN MENGGUNAKAN METODE EOQ (ECONOMIC ORDER QUANTITY) PADA PT. XYZ
Authors: Umami Dea Misbachul , Mu'tamar Mohammad Fuad Fauzul , Rakhmawati Rakhmawati 
Published: January 2019

Inventory control is one of the important things of working capital in a company. Economic Order Quantity (EOQ) could be decided from the safety stock, maximum inventory, and reorder point in a company. The aim of the research was to know the number of stock and inventory cost savings. The research used EOQ method on controlling the packaging cup 240 ml and carton box to know the amount of safety stock, maximum inventory, and reorder point in PT. XYZ. The result showed that the sum of buying the material based on EOQ method in the 2015, 2016 and 2017.In the 2015 the amount f packaging cup 240ml were 1.492.031 cups, the amount f carton box were 25.164 cartons, in the 2016 the sum of packaging cup 240 ml were 1.492.084 cups, the sum of cartoon box were 24.697 cartons, while in the 2017 the sum of packaging cup were 240 cups. Using the EOQ method can be known that inventory cost savings as the result of the decreasing of the order. Safety stock were around 447.406 for a 240ml cups and 9.319 for cartons box. Maximum inventory based on EOQ method were around 992.445 for 240 ml cups and 20.549 for cartons. Reorder point based on EOQ method were around 860.066 for a 240ml cups and 17.918 for cartons.
Keywords: EOQ, inventory control, maximum inventory, reorder point, safety stock
BEBAN PENCEMARAN KALI JOMPO DI KECAMATAN PATRANG-KALIWATES KABUPATEN JEMBER
Authors: Aziza Siti Nur , Wahyuningsih Sri , Novita Elida 
Published: January 2019

Jompo River is one of many tributaries in Jember District has become one of the water source for inhabitant around use for their daily needs. People activities can make water quality in Jompo River has been polluted gradually. The measurement need to knows water quality and polution load which enter in to Jompo River. Location of research was start form Patrang to Kaliwates District with six node and distantance 625 m. each node. This research was conducted in March-July 2017. Based on data analysis, average value of water quality ​​ were TSS was 67 mg / l, TDS was 104.78 mg / l, pH was 6.73, DO was 8.34 mg / l, and BOD was 1.20 mg / l. Based on Government Regulation No. 82 of 2001, the Jompo river water quality was included in class II criteria. The highest pollution load was at the 6th node of 394.39 kg/day. Jompo River has an average reaeration rate of 0.65 mg / l.day and deoxygenation rate of 0.284 mg / l.day. The river was ability to accomodate of pollution load because the rate of reaeration rate was higher than the value of deoxygenation rate.
Keywords: Jompo River, pollution load, water quality
KUALITAS LINGKUNGAN DI INDUSTRI RUMAH TANGGA PENYAMAKAN KULIT DAN KELUHAN KESEHATAN PEKERJA
Authors: Sandra Yopi Riski Mei , Sudarmaji Sudarmaji 
Published: January 2019

Pekerjaan penyamakan kulit mempergunakan air dalam jumlah yang relatif besar dan bahan kimia, sehingga usaha ini akan menghasilkan limbah cair yang mengandung berbagai polutan. Tujuan dari penelitian ini adalah menganalisis kualitas industri rumah tangga penyamakan kulit dan keluhan kesehatan. Desain penelitian ini observasional dengan studi deskriptif. Penelitian dilakukan di penyamakan kulit CV. Sidiq Bersaudara, Magetan, dengan populasi penelitian dari 15 pekerja laki-laki. Data yang digunakan adalah data primer dan sekunder. Hasil penelitian didapatkan mayoritas pekerja berumur <35 tahun, telah bekerja selama 5-10 tahun, memiliki pengetahuan jelek, memiliki sikap baik, higiene personal yang baik, dan selalu menggunakan alat pelindung diri (APD). Kualitas lingkungan meliputi kondisi fisik bangunan yang kuat, terdapat fasilitas sanitasi yang memadai, tidak memiliki instalasi pengelolaan limbah cair, diketemukan vektor lalat, dan dirasakan bau menyengat. Hasil pengukuran subjektif keluhan pekerja mayoritas pekerja gatal-gatal pada kulit dan pengujian kadar kromium dalam sampel urin pekerja keseluruhan masih dibawah angka normal yang ditetapkan dan kadar kromium air limbah outlet sebesar 0,799 mg/L melebihi baku mutu yang ditetapkan sebesar 0,5 mg/L.
Studi Fenomenologis Kepatuhan Terhadap Standar Akuntansi Pemerintahan Dalam Pelaporan Aset Biologis (Studi Kasus: Organisasi “X”)
Authors: Zulkarnain Arlin , Fanani Zaenal 
Published: January 2019

Implementation of SAP related biological assets generate a polemic against the compliance Financial Statements preparation of public sector organizations in Indonesia. The objectives of this study were to: (i) investigate the phenomenon of understanding/interpretation of public sector management SAP in the preparation of financial statements related to the treatment of biological assets; (ii) reveal the meaning of phenomena gained during the study; (iii) provide inputs based on summarized meanings, in an effort to improve SAP, government accounting policies, or related rules. This research used qualitative approach with the type of phenomenology study. Selected research sites in "X" organizations that have large quantities of biological assets with a focus on research sites at two production centers and vertical agencies (Directorate General and Secretariat General c.q. Financial Bureau). The results show that management applies as if obedient according to their understanding and interpretation of SAP. Management makes decisions regarding accounting policies with the justification of a problem that does not yet have a guideline. One example of measuring the inventory value of biological assets derived from its own production is by using the non-tax rate. In addition, the use of fair value today and in the future, is still an obstacle in the implementation of government organizations.
Scaling of Countercurrent Imbibition in 2D Matrix Blocks With Different Boundary Conditions
Authors: Meng Qingbang , Cai Jianchao , Wang Jing 
Published: January 2019

Summary
Scaling of imbibition data is of essential importance in predicting oil recovery from fractured reservoirs. In this work, oil recovery by countercurrent spontaneous imbibition from 2D matrix blocks with different boundary conditions was studied using numerical calculations. The numerical results show that the shape of imbibition-recovery curves changes with different boundary conditions. Therefore, the imbibition curves could not be closely correlated with a constant parameter. A modified characteristic length was proposed by a combination of Ma et al. (1997) and theoretical characteristic length. The modified characteristic length is a function of imbibition time, and the shape of imbibition curves could be changed using the modified characteristic length. The overall imbibition curves were closely correlated using the modified characteristic length. Finally, the modified characteristic length was verified by experimental data for imbibition with different boundary conditions.
Identification of homogeneous rainfall regions using a genetic algorithm involving multi-criteria decision making techniques
Authors: Debbarma Nilotpal , Choudhury Parthasarathi , Roy Parthajit 
Published: January 2019

AbstractThe detection of appropriate homogeneous regions is an important step in regional frequency analysis with the determination of homogeneity depending to a great extent on the type of method used in grouping. So, the study considers a genetic-algorithm-based clustering method to identify homogeneous precipitation regions for 39 gauge stations of the north-eastern region of India. The performance evaluation is done using six cluster validation measures. Further, considering all the six indices together, selection for the optimum cluster is modelled as a multi-criteria decision making (MCDM) problem. Three MCDM methods, namely TOPSIS, WASPAS and VIKOR, are applied to obtain ranked clusters which are then subjected to a heterogeneity test using the L-moments approach. The results suggested the stations to be grouped into three homogeneous regions. Comparison with the k-means method indicated relatively better performance for genetic-algorithm-based clustering. Finally, an L-moment ratio diagram and goodness-of-fit measures were conducted to select regional frequency distributions for the identified homogeneous regions.
Desalination using modified configuration of supported liquid membrane with enhancement of mass transfer of NaCl
Authors: Naim Mona M. , Moneer Abeer A. , Elewa Mahmoud M. , El-Shafei Ahmed A. 
Published: January 2019

Abstract
Supported liquid membranes (SLM) suffer from very slow mass transfer of the solute from the donor phase (DP) to the receptor phase (RP) through the liquid membrane (LM). In the present work, an attempt was made to accelerate the mass transfer in SLM by creating a modified configuration in which the DP and RP are made to flow either co- or counter-currently to each other. Variables, which could affect the removal of NaCl, were the volume ratio of DP to RP, type and quantity of sequestering agent (SA), presence of mobile carrier (MC), type of LM, and flow rate of DP and RP. The results showed that the higher the flow rate of DP and RP, the higher the mass transfer of NaCl. Quantity and type of SA and type of LM were prime important factors. Remarkably, the time required for transfer of NaCl from DP to RP was reduced from several hours in the case of stagnant SLM to several minutes in the present work. The mass transfer of NaCl was analysed based on kinetic laws of two consecutive irreversible first-order reactions. The values achieved establish the process is diffusion controlled, and the membrane entrance rate constants increase directly with initial concentration (Ci) and inversely with quantity of SA.
Cinnamaldehyde Analogs: Docking Based Optimization, COX-2 Inhibitory In Vivo and In Vitro Studies
Authors: Patil Vaishali M. , Anand Preeti , Bhardwaj Monika , Masand Neeraj 
Published: January 2019

Background:In the past decade CADD has emerged as a rational approach in drug development so with the help molecular docking approach we planned to perform virtual screening of the designed data set of Schiff bases of cinnamaldehyde. The research work will be helpful to put some light on the drug receptor interactions required for anti-inflammatory activity.Methods:For carrying out virtual screening of the developed cinnamaldehyde Schiff base data set, AutoDock 4.0 was used. The active hits identified through in silico screening were synthesized. Anti-inflammatory evaluation was carried out using Carrageenan-induced paw oedema method.Results:Compounds V2A44, V2A55, V2A76, V2A82, V2A119, V2A141 and V2A142 has shown highest binding energy (-4.84, -4.76, -4.59, -4.78, -4.74, -4.85 and -4.72 kcal/mol, respectively) and the binding interactions with amino acids namely, Phe478, Glu479, Lys492, Ala493, Asp497 and Ile498. Some of the analogs have shown significant activity and were comparable to Indomethacin (standard drug).Conclusion:Five new compounds have shown significant activity and the results obtained from in silico studies are parallel to those of in vivo studies.
Maternal and Fetal Outcomes in Iranian Patients with Systemic Lupus Erythematosus: A Five-Year Retrospective Study of 60 Pregnancies
Authors: Karimzadeh P. , Shenavandeh S. , Asadi N. 
Published: January 2019

Background:
As a multisystem autoimmune disease, Systemic Lupus Erythematosus
(SLE) mainly affects women during reproductive age. This retrospective study was designed to investigate
the fetal and maternal outcomes of Iranian women with SLE.

Methods:
Clinical and laboratory records of 60 pregnancies in 55 SLE patients who attended Hafez
hospital, a tertiary referral center for high risk pregnancies and SLE patients affiliated with Shiraz
University of Medical Science, were reviewed during April 2012 and March 2016.

Results:
The mean age of the patients was 29.28±4.6 years and mean disease duration was 5.09±4.2
years. Live birth rate was 83.3% after exclusion of elective abortions. There were 50 live births, 3
neonatal deaths, 3 spontaneous abortions and 7 stillbirths. 9 (15%) women developed preeclampsia
and there was 1 (1.6%) case of HELLP syndrome. Lupus flares occurred in 27 (45%) patients during
pregnancy. Preterm delivery occurred in 11.6% of pregnancies. Skin and joints were the most
frequently affected organs. Patients with previous lupus nephritis (n=18) were associated with a
higher risk of maternal complication, but fetal outcomes were similar in both groups. Cesarean rate
was about 66%, mostly related to fetal indications (50%).

Conclusion:
Pregnancies in most women with pre-existing SLE can now be managed with successful
results although presence of previous lupus nephritis is still a major risk factor for adverse maternal
outcomes. In our study, fetal outcome was not different between patients with lupus nephritis
compared with the patients without nephritis who were under treatments. Hence, to achieve favorable
long-term results, we recommend regular multispecialty treatment approaches and progestational
counseling for women with SLE.
Allopurinol and Loss of Consciousness in a 78-old Year Man Suffering from Gout
Authors: Arian Mahnaz , AkbariRad Mina , Moghaddam Ahmad Bagheri , Firoozi Abdollah , Jami Mohammad 
Published: January 2019

:
Allopurinol is an FDA -Approved xanthine oxidase inhibitor, which is effective in the
treatment of gout, hyperuricemia and uremic kidney stones in patients with an increased level of
uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine into uric acid,
and therefore its inhibition results in decreased production of uric acid. The most common side effects
of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness,
abnormal hair loss, fever and hypersensitivity reaction.

Case Presentation:
This report represents a case of drug-induced meningitis of a senile man who
ended up in the ICU due to the remarkably reduced state of consciousness.
A Fast Algorithm for the Demosaicing Problem Concerning the Bayer Pattern
Authors: Boccuto Antonio , Gerace Ivan , Giorgetti Valentina , Rinaldi Matteo 
Published: January 2019

Introduction:
In this paper, we deal with the demosaicing problem when the Bayer pattern is used. We propose a fast heuristic algorithm, consisting of three parts.

Methods:
In the first one, we initialize the green channel by means of an edge-directed and weighted average technique. In the second part, the red and blue channels are updated, thanks to an equality constraint on the second derivatives. The third part consists of a constant-hue-based interpolation.

Results:
We show experimentally how the proposed algorithm gives in mean better reconstructions than more computationally expensive algorithms.