bluuebunny/crossref_metadata_2025_split huggingface dataset:
[Am(C5Me4H)3]: An Organometallic Americium Complex
Authors: Goodwin Conrad A. P. , Su Jing , Albrecht‐Schmitt Thomas E. , Blake Anastasia V. , Batista Enrique R. , Daly Scott R. , Dehnen Stefanie , Evans William J. , Gaunt Andrew J. , Kozimor Stosh A. , Lichtenberger Niels , Scott Brian L. , Yang Ping 
Published: June 2019

AbstractWe report the small‐scale synthesis, isolated yield, single‐crystal X‐ray structure, 1H NMR solution spectroscopy /solid‐state UV/Vis‐nIR spectroscopy, and density functional theory (DFT)/ab initio wave function theory calculations on an Am3+ organometallic complex, [Am(C5Me4H)3] (1). This constitutes the first quantitative data on Am−C bonding in a molecular species.
The Miharamycins and Amipurimycin: their Structural Revision and the Total Synthesis of the Latter
Authors: Wang Shengyang , Zhang Qingju , Zhao Yachen , Sun Jiansong , Kang Wenjia , Wang Fei , Pan Haixue , Tang Gongli , Yu Biao 
Published: June 2019

AbstractThe structural puzzle of amipurimycin, a peptidyl nucleoside antibiotic, is solved by total synthesis and X‐ray diffraction analysis, with the originally proposed configurations at C3′ and C8′ inverted and those at C6′, C2′′, and C3′′ corrected. A similar structural revision of the relevant miharamycins is proposed via chemical transformations and then validated by X‐ray diffraction analysis. The miharamycins bear an unusual trans‐fused dioxabicyclo[4.3.0]nonane sugar scaffold, which was previously assigned as being in the cis configuration.
Heterocyclization Strategy for Construction of Linear Conjugated Polymers: Efficient Metal‐Free Electrocatalysts for Oxygen Reduction
Authors: Long Xiaojing , Li Daohao , Wang Binbin , Jiang Zhenjie , Xu Wenjia , Wang Bingbing , Yang Dongjiang , Xia Yanzhi 
Published: June 2019

AbstractExploring cost‐effective and efficient metal‐free electrocatalysts for the oxygen reduction reaction (ORR) is crucial for the development of energy conversion and storage technologies. Reported here is a novel heterocyclization strategy to construct efficient ORR catalysts based on linear conjugated polymers (LCPs), which are composed of N‐, S‐, or Se‐heterocycles. Among these polymers, the covalently linked pyridine and thiophene molecule (P‐T) with reduced graphene oxide (rGO) exhibits a remarkable half‐wave potential of 0.79 V (vs. RHE) and excellent electrochemical stability, which are among the highest values for metal‐free polymers as ORR catalysts. Density‐functional theory (DFT) calculations reveal that the molecule with a phenyl unit (P‐Ph) is catalytically inactive, and when a thiophene unit is introduced to replace the phenyl unit in the conjugated backbone it features highly efficient electrocatalytic active sites. More importantly, the well‐defined molecular structures and controllable active sites in the pyrolysis and metal‐free polymers highlight new opportunities for the catalytic metal‐free ORR.
The Supramolecular Chemistry of Strained Carbon Nanohoops
Authors: Xu Youzhi , von Delius Max 
Published: June 2019

AbstractSince 1996, a growing number of strained macrocycles, comprising only sp2‐ or sp‐hybridized carbon atoms within the ring, have become synthetically accessible, with the [n]cycloparaphenyleneacetylenes (CPPAs) and the [n]cycloparaphenylenes (CPPs) being the most prominent examples. Now that robust and relatively general synthetic routes toward a diverse range of nanohoop structures have become available, the research focus is beginning to shift towards the exploration of their properties and applications. From a supramolecular chemistry perspective, these macrocycles offer unique opportunities as a result of their near‐perfect circular shape, the unusually high degree of shape‐persistence, and the presence of both convex and concave π‐faces. In this Minireview, we give an overview on the use of strained carbon‐rich nanohoops in host–guest chemistry, the preparation of mechanically interlocked architectures, and crystal engineering.
Synthesis of Arylacetaldehydes by Iridium‐Catalyzed Arylation of Vinylene Carbonate with Arylboronic Acids
Authors: Wang Zhe , Xue Fei , Hayashi Tamio 
Published: June 2019

AbstractThe one‐step synthesis of arylacetaldehydes by carbon–carbon bond formation between formylmethyl and aryl groups has been realized by the reaction of vinylene carbonate with arylboronic acids in the presence of an iridium/bisphosphine catalyst and a catalytic amount of tetrahydroxydiboron.
Facilitating plasmid nuclear delivery by interfering with the selective nuclear pore barrier
Authors: Azzam Ihab , Liashkovich Ivan , Luchtefeld Isabelle , Kouzel Ivan U. , Shahin Victor 
Published: June 2019

AbstractNuclear pore complexes (NPCs) are sophisticated transporters assembled from diverse proteins termed nucleoporins (Nups). They control all nucleocytoplasmic transport and form a stringent barrier between the cytosol and the nucleus. While selective receptor‐mediated transport enables translocation of macromolecules up to striking sizes approaching megadalton‐scale, the upper cutoff for diffusion is at 40 kDa. Raising the cutoff is of particular importance for nuclear delivery of therapeutic nanoparticles, for example, gene and chemotherapy. In this work, we set out to present compounds capable of raising the cutoff to an extent enabling nuclear delivery of 6 kbp pDNA (150 kDa) in cultured human vascular endothelial cells. Of all tested compounds one is singled out, 1,6‐hexanediol (1,6‐HD). Our observations reveal that 1,6‐HD facilitates nuclear delivery of pDNA in up to 10–20% of the tested cells, compared to no delivery at all in control conditions. It acts by interfering with bonds between Nups that occupy the NPC channel and confer transport selectivity. It also largely maintains cell viability even at high concentrations. We envisage that 1,6‐HD may serve as a lead substance and usher in the design of potent new strategies to increase nuclear delivery of therapeutic nanoparticles.
Quality of life in pediatric acute myeloid leukemia: Report from the Children's Oncology Group
Authors: Nagarajan Rajaram , Gerbing Robert , Alonzo Todd , Johnston Donna L. , Aplenc Richard , Kolb Edward A. , Meshinchi Soheil , Barakat Lamia P. , Sung Lillian 
Published: June 2019

AbstractIntroductionObjectives were used to describe guardian proxy‐report and child self‐report quality of life (QoL) during chemotherapy for pediatric acute myeloid leukemia (AML) patients.MethodsPatients enrolled on the phase 3 AML trial AAML1031 who were 2‐18 years of age with English‐speaking guardians were eligible. Instruments used were the PedsQL Generic Core Scales, Acute Cancer Module, and Multidimensional Fatigue Scale. Assessments were obtained at the beginning of Induction 1 and following completion of cycles 2‐4. Potential predictors of QoL included the total number of nonhematological grade 3‐4 Common Terminology Criteria for Adverse Event (CTCAE) submissions.ResultsThere were 505 eligible guardians who consented to participate and 348 of their children provided at least one self‐report assessment. The number of submitted CTCAE toxicities was significantly associated with worse physical health summary scores (β ± standard error (SE) −3.00 ± 0.69; P < 0.001) and general fatigue (β ± SE −2.50 ± 0.66; P < 0.001). Older age was significantly associated with more fatigue (β ± SE −0.58 ± 0.25; P = 0.022). Gender, white race, Hispanic ethnicity, private insurance status, risk status, bortezomib assignment, and duration of neutropenia were not significantly associated with QoL.DiscussionThe number of CTCAE toxicities was the primary factor influencing QoL among children with AML. Reducing toxicities should improve QoL; identifying approaches to ameliorate them should be a priority.
Modulation and Visualization of EF‐G Power Stroke During Ribosomal Translocation
Authors: Yin Heng , Gavriliuc Miriam , Lin Ran , Xu Shoujun , Wang Yuhong 
Published: June 2019

AbstractDuring ribosome translocation, the elongation factor EF‐G undergoes large conformational change while maintaining its contact with the moving tRNA. We previously measured a power stroke accompanying EF‐G catalysis, which was consistent with structural studies. However, the role of power stroke in translocation fidelity remains unclear. Here, we report quantitative measurements of the power strokes of structurally modified EF‐Gs by using two different techniques and reveal the correlation between power stroke and translocation efficiency and fidelity. We discovered that the reduced power stroke only lowered the percentage of translocation but did not introduce translocation error. The established force ‐structure–function correlation for EF‐G indicates that power stroke drives ribosomal translocation, but the mRNA reading frame is probably maintained by ribosome itself. Furthermore, the microscope detection method reported here can be simply implemented for other biochemical applications.
Controlling Pyrene Association in DNA Duplexes by B‐ to Z‐DNA Transitions
Authors: Nakamura Mitsunobu , Takada Tadao , Yamana Kazushige 
Published: June 2019

AbstractB‐ to Z‐DNA transitions play a crucial role in biological systems and have attracted the interest of researchers for their applications in DNA nanotechnology. DNA and DNA analogues have also been used as templates to construct helical chromophore associations with π interactions. In this work, the B‐ to Z‐DNA transition‐induced switching of pyrene in an association manner was evaluated using DNA duplexes with non‐nucleosidic pyrene residues in the middle of d(CG) repeat sequences. One of the pyrene‐labeled DNAs was shown to exhibit inverted exciton coupled circular dichroism signals upon pyrene association through a B‐ to Z‐DNA transition. This observation indicates that pyrene association switches the DNA conformation from right‐ to left‐handed. Interestingly, the fluorescence of the pyrene‐labeled DNA duplex also dynamically changed upon switching of the pyrene in an association‐based manner. Taken together, these studies demonstrate that pyrene‐labeled DNA shows promise as a chiroptical molecular switch.
Catalytic Performance of Layered Double Hydroxides (LDHs) Derived Materials in Gas‐Solid and Liquid‐Solid Phase Reactions
Authors: Huang Liang , Megías‐Sayago Cristina , Bingre Rogeria , Zheng Qianwen , Wang Qiang , Louis Benoît 
Published: June 2019

AbstractNovel layered double hydroxides (LDHs) were prepared by a co‐precipitation method and characterised using X‐ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT‐IR), Thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). As‐prepared LDH derived catalysts were first evaluated in the gas‐phase conversion of methanol. The results indicate that LDH derived materials act as selective catalysts towards dimethyl ether (DME), methane or light olefins formation, depending on their chemical composition. For instance, CuAlOx showed a high selectivity in DME up to 88 %, whilst CuCoOx converted methanol to CH4, C3H8 and DME. NiFeOx allowed achieving a full methanol conversion selectively into CH4 during at least 1800 min. Besides, Ni and Cu‐LDHs were successfully tested in the liquid phase benzyl alcohol (BzOH) oxidation leading to more than 50 % conversion. NiAl‐LDH appeared as the best catalyst for benzaldehyde production with a 71 % conversion and 100 % selectivity.
Self‐Propagated para‐Fluoro‐Thiol Reaction
Authors: Cavalli Federica , Bloesser Fabian R. , Barner‐Kowollik Christopher , Barner Leonie 
Published: June 2019

AbstractWe introduce a protecting‐group‐free concept for the powerful para‐fluoro‐thiol reaction (PFTR) employing a source of fluoride ions as base. The reaction is shown to be self‐propagating, with under‐stoichiometric amounts of base, thus effectively foregoing the need for high base concentrations. Careful tuning of the solvent–thiol combination allows for quantitative conversion, in some cases within a short timeframe, when only minimal amounts of base are used, allowing the PFTR reaction to essentially proceed base‐free.
Hot‐Tailoring of Carbon Nitride Dots with Redshifted Photoluminescence for Visual Double Text Encryption and Bioimaging
Authors: Yang Mengran , Mei Hao , Shen Yanfei , Wu Kaiqing , Pan Deng , Liu Songqin , Zhang Ting , Zhang Yuanjian 
Published: June 2019

AbstractThe fabrication of carbon dots and their doped forms by top‐down chemical cleavage has attracted considerable attention in the efforts to meet the increasing demands for optoelectronic applications ranging from biosensing to electro‐ and photocatalysis. However, due to strong quantum confinement effects, the size decrease often leads to an increase in the band gap, even in the emission of deep‐ultraviolet (DUV) light, which greatly limits their applications. Here, we report a facile hot‐tailoring strategy for fabricating carbon nitride nanodots (CNDs) with redshifted intrinsic photoluminescent (PL) emission, compared with the pristine bulk precursor. It has been found that the different leaving abilities of the C,N‐containing groups during the pyrolysis stage and the chemical passivation during the liquid‐collection stage played vital roles. Due to the redshifted photoluminescence and other attractive features, the as‐obtained CNDs were successfully applied in visual double text encryption with higher security and also in bioimaging with photostability superior to traditional dyes. This work highlights the great potential of the hot‐tailoring method in modulating carbon‐based nanostructures and offsetting band‐gap widening as the size decreases.
Breast cancer subtypes among Eastern‐African–born black women and other black women in the United States
Authors: Sung Hyuna , DeSantis Carol E. , Fedewa Stacey A. , Kantelhardt Eva J. , Jemal Ahmedin 
Published: June 2019

BackgroundA previous study reported that Eastern‐African–born black women in the United States had lower prevalence of estrogen receptor‐negative breast cancer than those in US‐born and Western‐African–born black women, among whom the prevalence was similar. It is unknown whether the prevalence of triple‐negative breast cancer (negative for estrogen receptor, progesterone receptor, and human epidermal growth factor 2 receptor) among black women in the United States differs similarly by birthplace.MethodsIn the National Program of Cancer Registries and US Cancer Statistics, the authors identified 65,211 non‐Hispanic black women who were diagnosed with invasive breast cancer from 2010 through 2015 and were recorded as being born in the United States, East Africa, West Africa, or the Caribbean. The prevalence of triple‐negative and hormone receptor‐negative breast cancer (negative for estrogen receptor and progesterone receptor) among each group of foreign‐born black women was compared with that among US‐born black women and was expressed as the adjusted prevalence rate ratio, accounting for sociodemographic and tumor characteristics. Analyses were stratified by Census region, and region‐specific estimates were summarized using random‐effects meta‐analyses.ResultsCompared with US‐born black women, the prevalence rate ratio of triple‐negative breast cancer was 0.92 (95% CI, 0.81‐1.04) among Western‐African–born, 0.87 (95% CI, 0.78‐0.98) among Caribbean‐born, and 0.53 (95% CI, 0.37‐0.77) among Eastern‐African–born black women. Patterns for hormone receptor‐negative tumors were generally similar, although the differences between populations were attenuated. The test for heterogeneity by Census region was not significant in any of the comparisons (all P for heterogeneity >.05).ConclusionsThe prevalence of triple‐negative breast cancer among black women in the United States varied significantly by birthplace, particularly among Eastern‐African–born black women. These findings underscore the importance of considering geographic origin in studies characterizing breast cancer among women of African descent in the United States and elsewhere.
Dynamics and Kinetics of Methanol‐Graphite Interactions at Low Surface Coverage
Authors: Kong Xiangrui , Thomson Erik S. , Marković Nikola , Pettersson Jan B. C. 
Published: June 2019

AbstractThe processes of molecular clustering, condensation, nucleation, and growth of bulk materials on surfaces, represent a spectrum of vapor‐surface interactions that are important to a range of physical phenomena. Here, we describe studies of the initial stages of methanol condensation on graphite, which is a simple model system where gas–surface interactions can be described in detail using combined experimental and theoretical methods. Experimental molecular beam methods and computational molecular dynamics simulations are used to investigate collision dynamics and surface accommodation of methanol molecules and clusters at temperatures from 160 K to 240 K. Both single molecules and methanol clusters efficiently trap on graphite, and even in rarified systems methanol‐methanol interactions quickly become important. A kinetic model is developed to simulate the observed behavior, including the residence time of trapped molecules and the quantified Arrhenius kinetics. Trapped molecules are concluded to rapidly diffuse on the surface to find and/or form clusters already at surface coverages below 10−6 monolayers. Conversely, clusters that undergo surface collisions fragment and subsequently lose more loosely bound molecules. Thus, the surface mediates molecular collisions in a manner that minimizes the importance of initial cluster size, but highlights a strong sensitivity to surface diffusion and intermolecular interactions between the hydrogen bonded molecules.
Green product innovation, green dynamic capability, and competitive advantage: Evidence from Chinese manufacturing enterprises
Authors: Qiu Lu , Jie Xiaowen , Wang Yanan , Zhao Minjuan 
Published: June 2019

AbstractThis study focuses on how green product innovation affects green dynamic capability and competitive advantage in the Chinese manufacturing industry. The empirical research indicates that green product innovation is positively correlated with both competitive advantage and green dynamic capability, whereas green dynamic capability also has a significant impact on competitive advantage. Furthermore, this paper finds that the resource integration capability, resource reconfiguration capability, and environmental insight capability of green dynamic capability play intermediary roles between green product innovation and competitive advantage. Corporate reputation positively moderates the relationship between green product innovation and resource integration capability and positively moderates the relationship between green product innovation and resource reconfiguration capability, whereas there is no moderating effect between green product innovation and environmental insight capability.
Sensor technology implementation for research, treatment, and assessment of eating disorders
Authors: Levinson Cheri A. , Christian Caroline , Shankar‐Ram Shruti , Brosof Leigh C. , Williams Brenna 
Published: June 2019

AbstractSensor technology has made huge technological advances in the past decade. Many sensor technologies (e.g., wearable wristbands) have been integrated into health research with the ability to substantially improve health outcomes and reduce health care costs. Despite the rapid technological developments in sensor technology, little research has examined sensor technology in eating disorders (EDs). The overarching aim of the current article is to briefly review the literature on sensor technology and health outcomes, including EDs, and discuss several potential ideas for the application of sensor technology in the treatment, assessment, and diagnosis of EDs. We will also present data from a feasibility case study with an ED participant and healthy control providing a brief example of how wearable sensor technology might be implemented in ED research. Overall, we will discuss how sensor technology could be used to improve treatment and assessment of EDs and represents an idea in need of more research in the ED field.
High species diversity and turnover in granite inselberg floras highlight the need for a conservation strategy protecting many outcrops
Authors: Yates Colin J. , Robinson Todd , Wardell‐Johnson Grant W. , Keppel Gunnar , Hopper Stephen D. , Schut Antonius G. T. , Byrne Margaret 
Published: June 2019

AbstractDetermining patterns of plant diversity on granite inselbergs is an important task for conservation biogeography due to mounting threats. However, beyond the tropics there are relatively few quantitative studies of floristic diversity, or consideration of these patterns and their environmental, biogeographic, and historical correlates for conservation. We sought to contribute broader understanding of global patterns of species diversity on granite inselbergs and inform biodiversity conservation in the globally significant Southwest Australian Floristic Region (SWAFR). We surveyed floristics from 16 inselbergs (478 plots) across the climate gradient of the SWAFR stratified into three major habitats on each outcrop. We recorded 1,060 species from 92 families. At the plot level, local soil and topographic variables affecting aridity were correlated with species richness in herbaceous (HO) and woody vegetation (WO) of soil‐filled depressions, but not in woody vegetation on deeper soils at the base of outcrops (WOB). At the outcrop level, bioclimatic variables affecting aridity were correlated with species richness in two habitats (WO and WOB) but, contrary to predictions from island biogeography, were not correlated with inselberg area and isolation in any of the three habitats. Species turnover in each of the three habitats was also influenced by aridity, being correlated with bioclimatic variables and with interplot geographic distance, and for HO and WO habitats with local site variables. At the outcrop level, species replacement was the dominant component of species turnover in each of the three habitats, consistent with expectations for long‐term stable landscapes. Our results therefore highlight high species diversity and turnover associated with granite outcrop flora. Hence, effective conservation strategies will need to focus on protecting multiple inselbergs across the entire climate gradient of the region.
Multiple aspects of the selfing syndrome of the morning glory Ipomoea lacunosa evolved in response to selection: A Qst‐Fst comparison
Authors: Rifkin Joanna L. , Liao Irene T. , Castillo Allan S. , Rausher Mark D. 
Published: June 2019

AbstractThe frequent transition from outcrossing to selfing in flowering plants is often accompanied by changes in multiple aspects of floral morphology, termed the “selfing syndrome.” While the repeated evolution of these changes suggests a role for natural selection, genetic drift may also be responsible. To determine whether selection or drift shaped different aspects of the pollination syndrome and mating system in the highly selfing morning glory Ipomoea lacunosa, we performed multivariate and univariate Qst‐Fst comparisons using a wide sample of populations of I. lacunosa and its mixed‐mating sister species Ipomoea cordatotriloba. The two species differ in early growth, floral display, inflorescence traits, corolla size, nectar, and pollen number. Our analyses support a role for natural selection driving trait divergence, specifically in corolla size and nectar traits, but not in early growth, display size, inflorescence length, or pollen traits. We also find evidence of selection for reduced herkogamy in I. lacunosa, consistent with selection driving both the transition in mating system and the correlated floral changes. Our research demonstrates that while some aspects of the selfing syndrome evolved in response to selection, others likely evolved due to drift or correlated selection, and the balance between these forces may vary across selfing species.