bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal camouflage based on the phase-changing material GST
Authors: Qu Yurui , Li Qiang , Cai Lu , Pan Meiyan , Ghosh Pintu , Du Kaikai , Qiu Min 
Published: June 2018

AbstractCamouflage technology has attracted growing interest for many thermal applications. Previous experimental demonstrations of thermal camouflage technology have not adequately explored the ability to continuously camouflage objects either at varying background temperatures or for wide observation angles. In this study, a thermal camouflage device incorporating the phase-changing material Ge2Sb2Te5 (GST) is experimentally demonstrated. It has been shown that near-perfect thermal camouflage can be continuously achieved for background temperatures ranging from 30 °C to 50 °C by tuning the emissivity of the device, which is attained by controlling the GST phase change. The thermal camouflage is robust when the observation angle is changed from 0° to 60°. This demonstration paves the way toward dynamic thermal emission control both within the scientific field and for practical applications in thermal information.
Uncovering hidden brain state dynamics that regulate performance and decision-making during cognition
Authors: Taghia Jalil , Cai Weidong , Ryali Srikanth , Kochalka John , Nicholas Jonathan , Chen Tianwen , Menon Vinod 
Published: June 2018

AbstractHuman cognition is influenced not only by external task demands but also latent mental processes and brain states that change over time. Here, we use novel Bayesian switching dynamical systems algorithm to identify hidden brain states and determine that these states are only weakly aligned with external task conditions. We compute state transition probabilities and demonstrate how dynamic transitions between hidden states allow flexible reconfiguration of functional brain circuits. Crucially, we identify latent transient brain states and dynamic functional circuits that are optimal for cognition and show that failure to engage these states in a timely manner is associated with poorer task performance and weaker decision-making dynamics. We replicate findings in a large sample (N = 122) and reveal a robust link between cognition and flexible latent brain state dynamics. Our study demonstrates the power of switching dynamical systems models for investigating hidden dynamic brain states and functional interactions underlying human cognition.
Extremely strong polarization of an active asteroid (3200) Phaethon
Authors: Ito Takashi , Ishiguro Masateru , Arai Tomoko , Imai Masataka , Sekiguchi Tomohiko , Bach Yoonsoo P. , Kwon Yuna G. , Kobayashi Masanori , Ishimaru Ryo , Naito Hiroyuki , Watanabe Makoto , Kuramoto Kiyoshi 
Published: June 2018

AbstractThe near-Earth asteroid (3200) Phaethon is the parent body of the Geminid meteor stream. Phaethon is also an active asteroid with a very blue spectrum. We conducted polarimetric observations of this asteroid over a wide range of solar phase angles α during its close approach to the Earth in autumn 2016. Our observation revealed that Phaethon exhibits extremely large linear polarization: P = 50.0 ± 1.1% at α = 106.5°, and its maximum is even larger. The strong polarization implies that Phaethon’s geometric albedo is lower than the current estimate obtained through radiometric observation. This possibility stems from the potential uncertainty in Phaethon’s absolute magnitude. An alternative possibility is that relatively large grains (~300 μm in diameter, presumably due to extensive heating near its perihelion) dominate this asteroid’s surface. In addition, the asteroid’s surface porosity, if it is substantially large, can also be an effective cause of this polarization.
mTORC1 accelerates retinal development via the immunoproteasome
Authors: Choi Ji-Heon , Jo Hong Seok , Lim Soyeon , Kim Hyoung-Tai , Lee Kang Woo , Moon Kyeong Hwan , Ha Taejeong , Kwak Sang Soo , Kim Yeha , Lee Eun Jung , Joe Cheol O. , Kim Jin Woo 
Published: June 2018

AbstractThe numbers and types of cells constituting vertebrate neural tissues are determined by cellular mechanisms that couple neurogenesis to the proliferation of neural progenitor cells. Here we identified a role of mammalian target of rapamycin complex 1 (mTORC1) in the development of neural tissue, showing that it accelerates progenitor cell cycle progression and neurogenesis in mTORC1-hyperactive tuberous sclerosis complex 1 (Tsc1)-deficient mouse retina. We also show that concomitant loss of immunoproteasome subunit Psmb9, which is induced by Stat1 (signal transducer and activator of transcription factor 1), decelerates cell cycle progression ofTsc1-deficient mouse retinal progenitor cells and normalizes retinal developmental schedule. Collectively, our results establish a developmental role for mTORC1, showing that it promotes neural development through activation of protein turnover via a mechanism involving the immunoproteasome.
The role of PANSS symptoms and adverse events in explaining the effects of paliperidone on social functioning: a causal mediation analysis approach
Authors: Zou Xue , Zhu Yiwen , Jackson John W. , Bellavia Andrea , Fitzmaurice Garrett M. , Centorrino Franca , Valeri Linda 
Published: June 2018

AbstractTo date, no study has evaluated the joint role of symptoms and adverse events as mediators of the effect of second-generation antipsychotics on patients’ social functioning. We used recently developed methods for mediation analysis with multiple mediators to clarify the interplay of adverse events and symptoms in explaining the effects of paliperidone (R code for implementing the mediation analysis for multiple mediators is provided). We used data from 490 participants in a 6-week randomized dose–response trial that assigned three fixed dosages of ER OROS paliperidone (3, 9, and 15 mg/day). The primary outcome was an individual’s score on the social performance scale assessed after 6 weeks. The sum of Positive and Negative Syndrome Scale (PANSS), weight gain, and extrapyramidal symptoms measured via the Simpson–Angus Scale after 5 weeks were investigated as potential mediators and effect modifiers of treatment effects. Results from mediation analyses showed that the improvements in social functioning are partly explained by reduction in PANSS symptoms. Suggestive evidence that adverse events could play a role as mediators was found. In particular, weight gain displayed a non-linear relationship with social functioning, whereby beneficial effects observed at small levels of weight gain were reduced in the presence of excessive weight gain. In conclusion, we found that the short-term effects of paliperidone on social functioning were dependent on the successful reduction in PANSS symptoms and possibly the occurrence of excessive weight gain, thus suggesting future directions for treatment and interventions.
Cross-Cultural Evidence for Apparent Racial Outgroup Advantage: Congruence between Perceived Facial Aggressiveness and Fighting Success
Authors: Třebický Vít , Saribay S. Adil , Kleisner Karel , Akoko Robert Mbe , Kočnar Tomáš , Valentova Jaroslava Varella , Varella Marco Antonio Correa , Havlíček Jan 
Published: June 2018

AbstractResearch into face processing consistently shows an outgroup disadvantage in areas such as recognition memory and emotional identification. Potential ingroup advantage with respect to inferences regarding personality and behavioural outcomes, on the other hand, has not yet been studied. In the present study, we used the faces of male professional mixed martial arts (MMA) fighters of apparent African, European, or mixed-race origin as targets and males from four distant populations that vary in ethnic composition as perceivers. We compared the perceivers’ inferences about targets’ aggressiveness with the fighters’ actual performance in professional MMA championships. Surprisingly, across three distant populations used in the study (Cameroon, Czech Republic, and Turkey), perceivers’ inferences based on face rating were more congruent with real-world performance for targets belonging to an apparent racial outgroup (as opposed to ingroup). In an ethnically mixed population (Brazil), perceivers showed the lowest congruence for apparently mixed-race targets. It thus seems that the outgroup disadvantage observed in other face processing domains does not carry over to inferences about aggressive behavioural outcomes. In fact, it seems that this relationship is, if anything, reversed.
Characterizing human subchondral bone properties using near-infrared (NIR) spectroscopy
Authors: Afara Isaac O. , Florea Cristina , Olumegbon Ismail A. , Eneh Chibuzor T. , Malo Markus K. H. , Korhonen Rami K. , Töyräs Juha 
Published: June 2018

AbstractDegenerative joint conditions are often characterized by changes in articular cartilage and subchondral bone properties. These changes are often associated with subchondral plate thickness and trabecular bone morphology. Thus, evaluating subchondral bone integrity could provide essential insights for diagnosis of joint pathologies. This study investigates the potential of optical spectroscopy for characterizing human subchondral bone properties. Osteochondral samples (n = 50) were extracted from human cadaver knees (n = 13) at four anatomical locations and subjected to NIR spectroscopy. The samples were then imaged using micro-computed tomography to determine subchondral bone morphometric properties, including: plate thickness (Sb.Th), trabecular thickness (Tb.Th), volume fraction (BV/TV), and structure model index (SMI). The relationship between the subchondral bone properties and spectral data in the 1st (650–950 nm), 2nd (1100–1350 nm) and 3rd (1600–1870 nm) optical windows were investigated using partial least squares (PLS) regression multivariate technique. Significant correlations (p < 0.0001) and relatively low prediction errors were obtained between spectral data in the 1st optical window and Sb.Th (R2 = 92.3%, error = 7.1%), Tb.Th (R2 = 88.4%, error = 6.7%), BV/TV (R2 = 83%, error = 9.8%) and SMI (R2 = 79.7%, error = 10.8%). Thus, NIR spectroscopy in the 1st tissue optical window is capable of characterizing and estimating subchondral bone properties, and can potentially be adapted during arthroscopy.
Structural basis of the correct subunit assembly, aggregation, and intracellular degradation of nylon hydrolase
Authors: Negoro Seiji , Shibata Naoki , Lee Young-Ho , Takehara Ikki , Kinugasa Ryo , Nagai Keisuke , Tanaka Yusuke , Kato Dai-ichiro , Takeo Masahiro , Goto Yuji , Higuchi Yoshiki 
Published: June 2018

AbstractNylon hydrolase (NylC) is initially expressed as an inactive precursor (36 kDa). The precursor is cleaved autocatalytically at Asn266/Thr267 to generate an active enzyme composed of an α subunit (27 kDa) and a β subunit (9 kDa). Four αβ heterodimers (molecules A-D) form a doughnut-shaped quaternary structure. In this study, the thermostability of the parental NylC was altered by amino acid substitutions located at the A/D interface (D122G/H130Y/D36A/L137A) or the A/B interface (E263Q) and spanned a range of 47 °C. Considering structural, biophysical, and biochemical analyses, we discuss the structural basis of the stability of nylon hydrolase. From the analytical centrifugation data obtained regarding the various mutant enzymes, we conclude that the assembly of the monomeric units is dynamically altered by the mutations. Finally, we propose a model that can predict whether the fate of the nascent polypeptide will be correct subunit assembly, inappropriate protein-protein interactions causing aggregation, or intracellular degradation of the polypeptide.
Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation
Authors: Wakae Kousho , Nishiyama Tomoaki , Kondo Satoru , Izuka Takashi , Que Lusheng , Chen Cong , Kase Kina , Kitamura Kouichi , Mohiuddin Md , Wang Zhe , Ahasan Md Monjurul , Nakamura Mitsuhiro , Fujiwara Hiroshi , Yoshizaki Tomokazu , Hosomochi Kazuyoshi , Tajima Atsushi , Nakahara Tomomi , Kiyono Tohru , Muramatsu Masamichi 
Published: June 2018

AbstractMitochondrial DNA (mtDNA) mutations are found in many types of cancers and suspected to be involved in carcinogenesis, although the mechanism has not been elucidated. In this study, we report that consecutive C-to-T mutations (hypermutations), a unique feature of mutations induced by APOBECs, are found in mtDNA from cervical dysplasia and oropharyngeal cancers. In vitro, we found that APOBEC3A (A3A) and 3B (A3B) expression, as well as mtDNA hypermutation, were induced in a cervical dysplastic cell line W12 when cultured in a differentiating condition. The ectopic expression of A3A or A3B was sufficient to hypermutate mtDNA. Fractionation of W12 cell lysates and immunocytochemical analysis revealed that A3A and A3B could be contained in mitochondrion. These results suggest that mtDNA hypermutation is induced upon keratinocyte differentiation, and shed light on its molecular mechanism, which involves A3s. The possible involvement of mtDNA hypermutations in carcinogenesis is also discussed.
Positron Annihilation Studies on Chemically Synthesized FeCo Alloy
Authors: Rajesh P. , Sellaiyan S. , Uedono A. , Arun T. , Joseyphus R. Justin 
Published: June 2018

AbstractEquiatomic flower-like FeCo magnetic nanoparticles are synthesized through a modified one-pot polyol technique. The as-prepared samples are annealed at 700 and 800 °C under reducing atmosphere. The saturation magnetization and coercivity of the flower-like FeCo are found to be 198 (1) emu/g and 243 (10) Oe respectively. The magnetic properties of FeCo approach the bulk behavior with annealing. Positron lifetime studies on the chemically synthesized equiatomic FeCo magnetic nanoparticles with flower-like morphology are reported and compared with Fe, Co and FeCo annealed at various temperatures. The FeCo is characterized by different lifetime components corresponding to positron annihilation events in vacancies and various open volume defects due to their unique morphology. The studies suggest defects arising out of cluster vacancies and interpetal gap that reduce on annealing. The average pore size obtained from positron annihilation studies closely matches with the interpetal distance obtained from the electron microscopic analysis for the flower-like FeCo.
Origin and classification of spontaneous discharges in mouse superficial dorsal horn neurons
Authors: Lucas-Romero Javier , Rivera-Arconada Ivan , Roza Carolina , Lopez-Garcia Jose A. 
Published: June 2018

AbstractSuperficial laminae of the spinal cord possess a considerable number of neurons with spontaneous activity as reported in vivo and in vitro preparations of several species. Such neurons may play a role in the development of the nociceptive system and/or in the spinal coding of somatosensory signals. We have used electrophysiological techniques in a horizontal spinal cord slice preparation from adult mice to investigate how this activity is generated and what are the main patterns of activity that can be found. The results show the existence of neurons that fire regularly and irregularly. Within each of these main types, it was possible to distinguish patterns of spontaneous activity formed by single action potentials and different types of bursts according to intra-burst firing frequency. Activity in neurons with irregular patterns was blocked by a mixture of antagonists of the main neurotransmitter receptors present in the cord. Approximately 82% of neurons with a regular firing pattern were insensitive to synaptic antagonists but their activity was inhibited by specific ion channel blockers. It is suggested that these neurons generate endogenous activity due to the functional expression of hyperpolarisation-activated and persistent sodium currents driving the activity of irregular neurons.
Strong activation effect on a Ru-Co-C thin film catalyst for the hydrolysis of sodium borohydride
Authors: Arzac G. M. , Paladini M. , Godinho V. , Beltrán A. M. , Jiménez de Haro M. C. , Fernández A. 
Published: June 2018

AbstractIn this work, we prepared a series of Ni foam supported Ru-Co, Ru-Co-B and Ru-Co-C catalysts in the form of columnar thin films by magnetron sputtering for the hydrolysis of sodium borohydride. We studied the activity and durability upon cycling. We found a strong activation effect for the Ru-Co-C sample which was the highest ever reported. This catalyst reached in the second cycle an activity 5 times higher than the initial (maximum activity 9310 ml.min−1.gCoRu−1 at 25 °C). Catalytic studies and characterization of the fresh and used samples permitted to attribute the strong activation effect to the following factors: (i) small column width and amorphous character (ii) the presence of Ru and (iii) dry state before each cycle. The presence of boron in the initial composition is detrimental to the durability. Our studies point out to the idea that after the first cycle the activity is controlled by surface Ru, which is the most active of the two metals. Apart from the activation effect, we found that catalysts deactivated in further cycles. We ascribed this effect to the loss of cobalt in the form of hydroxides, showing that deactivation was controlled by the chemistry of Co, the major surface metal component of the alloy. Alloying with Ru is beneficial for the activity but not for the durability, and this should be improved.
Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells
Authors: Martin-Gallausiaux Camille , Béguet-Crespel Fabienne , Marinelli Ludovica , Jamet Alexandre , Ledue Florence , Blottière Hervé M. , Lapaque Nicolas 
Published: June 2018

AbstractThe intestinal microbiota contributes to the global wellbeing of their host by their fundamental role in the induction and maintenance of a healthy immune system. Commensal bacteria shape the mucosal immune system by influencing the proportion and the activation state of anti-inflammatory regulatory T cells (Treg) by metabolites that are still only partially unravelled. Microbiota members such as Clostridiales provide a transforming growth factor β (TGFβ)-rich environment that promotes the accumulation of Treg cells in the gut. The intestinal epithelial cells (IECs) take a central part in this process, as they are a major source of TGFβ1 upon bacterial colonisation. In this study, we investigated which gut commensal bacteria were able to regulate the TGFB1 human promoter in IECs using supernatants from cultured bacteria. We reported that Firmicutes and Fusobacteria supernatants were the most potent TGFB1 modulators in HT-29 cells. Furthermore, we demonstrated that butyrate was the main metabolite in bacterial supernatants accounting for TGFβ1 increase. This butyrate-driven effect was independent of the G-protein coupled receptors GPR41, GPR43 and GPR109a, the transporter MCT1 as well as the transcription factors NF-κB and AP-1 present on TGFB1 promoter. Interestingly, HDAC inhibitors were inducing a similar TGFB1 increase suggesting that butyrate acted through its HDAC inhibitor properties. Finally, our results showed that SP1 was the main transcription factor mediating the HDAC inhibitor effect of butyrate on TGFB1 expression. This is, to our knowledge, the first characterisation of the mechanisms underlying TGFB1 regulation in IEC by commensal bacteria derived butyrate.
Septicemia due to Streptococcus dysgalactiae subspecies dysgalactiae in vampire bats (Desmodus rotundus)
Authors: Mioni Mateus de Souza Ribeiro , Castro Fernando Favian Castro , Moreno Luisa Zanolli , Apolinário Camila Michelle , Belaz Lais Dario , Peres Marina Gea , Ribeiro Bruna Letícia Davidé , Castro Maria José da Silva , Ferreira Adriano Martison , Cortez Adriana , Moreno Andrea Micke , Heinemann Marcos Bryan , Megid Jane 
Published: June 2018

AbstractBeta-hemolytic Streptococcus dysgalactiae is a well-known pathogen for a wide range of animals and humans. Two subspecies are recognized: (i) equisimilis, associated to disease in horses and humans, and (ii) dysgalactiae mainly isolated from animal illness with only a few humans’ cases. This study describes the isolation and characterization of Streptococcus dysgalactiae subsp. dysgalactiae (SDSD) from vampire bats, maintained in captivity for research proposes. Animals presented neurologic, respiratory and gastroenteric symptoms and sudden death. Beta-hemolytic Gram-positive cocci were isolated in blood agar plates and further characterized as Lancefield group C. All isolates were identified as S. dysgalactiae by matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry and subspecies dysgalactiae was confirmed by 16S rRNA sequencing and phylogenetic analysis. Genotyping through SE-ALFP resulted in three profiles (A1–A3) with one bat being infected by profiles A1 and A3. This is the first report of SDSD causing illness in bats and especially in Desmodus rotundus species.
Transcriptomics analysis reveals new insights in E171-induced molecular alterations in a mouse model of colon cancer
Authors: Proquin Héloïse , Jetten Marlon J. , Jonkhout Marloes C. M. , Garduño-Balderas Luis Guillermo , Briedé Jacob J. , de Kok Theo M. , van Loveren Henk , Chirino Yolanda I. 
Published: June 2018

AbstractTitanium dioxide as a food additive (E171) has been demonstrated to facilitate growth of chemically induced colorectal tumours in vivo and induce transcriptomic changes suggestive of an immune system impairment and cancer development. The present study aimed to investigate the molecular mechanisms behind the tumour stimulatory effects of E171 in combination with azoxymethane (AOM)/dextran sodium sulphate (DSS) and compare these results to a recent study performed under the same conditions with E171 only. BALB/c mice underwent exposure to 5 mg/kgbw/day of E171 by gavage for 2, 7, 14, and 21 days. Whole genome mRNA microarray analyses on the distal colon were performed. The results show that E171 induced a downregulation of genes involved in the innate and adaptive immune system, suggesting impairment of this system. In addition, over time, signalling genes involved in colorectal cancer and other types of cancers were modulated. In relation to cancer development, effects potentially associated with oxidative stress were observed through modulation of genes related to antioxidant production. E171 affected genes involved in biotransformation of xenobiotics which can form reactive intermediates resulting in toxicological effects. These transcriptomics data reflect the early biological responses induced by E171 which precede tumour formation in an AOM/DSS mouse model.