bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 2-step fast-track elastometry service for advanced workup of nonalcoholic fatty liver disease (NAFLD) patients – single-center real-world experience of outpatient clinical practice
Authors: Alsenbesy Mohamed , Rau Monika , Weiss Johannes , Götze Oliver , Geier Andreas 
Published: October 2019

Abstract
Introduction and aims Nonalcoholic fatty liver disease (NAFLD) is increasing globally with an estimated prevalence of approximately 25 %. Nonalcoholic steatohepatitis as the progressive disease entity often leads to fibrosis and end-stage disease. The magnitude of NAFLD patients are not diagnosed and have no access to further clinical assessment. Diagnostic pathways for individual risk evaluation fitting with available resources are of utmost importance in real-world clinical practice.
Methods Retrospective analysis of 1346 anonymized outpatient datasets at Würzburg University Hospital, Germany. Transient elastography (TE) with controlled attenuation parameter and laboratory-based risk scores (NFS, FIB-4) were the main diagnostic workup tools for risk stratification.
Results After preselection based on questionnaire information NAFLD still accounts for one-fifth of patients in the liver outpatient service. More than 80 % of NAFLD patients receive their first-time diagnosis in our unit. Laboratory-based risk scores and TE are valuable tools for second-step risk assessment as shown in our clinical data analysis. Moreover, 65 % of NAFLD patients use inpatient services for at least 1 day. The policy to perform liver biopsy in high-risk patients above the recommended threshold of 9.6 kPa if any clinical doubt exists regarding the diagnosis of cirrhosis leads to a histological down staging in almost 80 %.
Conclusion Questionnaire-based referral from primary care followed by broadly available fast-track TE and eventually liver biopsy for selected patients is the standard practice in our unit. This approach represents a feasible model to handle the large gap between availability and clinical need for TE facilities.
Percutaneous transhepatic cholangioscopic lithotripsy using soft fiber-optic choledochoscope
Authors: Jin Hao , Fan Jinrui , Li Wei , Cui Min 
Published: October 2019

AbstractMany patients with intrahepatic cholelithiasis need surgical treatment during their life. For patients with hepatolithiasis, conventional therapy methods suggest partial hepatectomy or hepatic transplantation, while both kinds of surgery carry a considerable risk and trauma. Under such conditions, percutaneous transhepatic cholangioscopic lithotripsy provides an alternative method for hepatolithiasis treatment. Conventional rigid choledochoscope applied in percutaneous transhepatic cholangioscopic lithotripsy often lack sufficient flexibility for complete intrahepatic bile duct inspection. In this article, we report a case of one patient with complex hepatolithiasis and choledocholithiasis who received percutaneous transhepatic cholangioscopic lithotripsy using the newly-developed soft fiber-optic choledochoscope. This treatment represents a safe and effective outcome. We came to the conclusion that soft fiber-optic choledochoscope guided percutaneous transhepatic cholangioscopic lithotripsy seems a promising treatment option for selected patients with hepatolithiasis, especially for those who cannot accept conventional methods.
Selen und Schilddrüsenentzündungen
Authors: Stoll Günther 
Published: October 2019

ZusammenfassungSelen ist für die Synthese von Schilddrüsenhormonen und das Abfangen von reaktiven Sauerstoffspezies bei dieser Reaktion wichtig. Neben das Jod tritt somit Selen als ein wichtiges Spurenelement, das für die physiologische Thyroideafunktion unabdingbar ist. Sowohl bei einer Unterfunktion (Hypothyreose) als auch bei einer Überfunktion (Hyperthyreose) kann mit Selen therapeutisch eingegriffen werden. Noch völlig unterschätzt ist bislang der Einfluss von Selen auf eine korrekte Schilddrüsenfunktion während der Schwangerschaft sowie auf die neurokognitive Entwicklung des Kindes nach der Geburt.
Der Magnesiumhaushalt – Update 2019
Authors: Kisters Klaus , Gröber Uwe 
Published: October 2019

ZusammenfassungMagnesium muss als essenzieller Mineralstoff in ausreichenden Mengen zugeführt werden. Die klinische Bedeutung der Magnesiumüberladung bzw. -intoxikation ist eher gering. Ein Magnesiummangel mit reduzierten Enzymaktivitäten tritt beim Menschen häufig auf, er lässt sich jedoch schwer nachweisen. Eine kausale Therapie der Hypomagnesiämie ist durch Sicherstellung des normalen Tagesbedarfs sowie durch Beseitigung hormonaler und medikamentöser Ursachen möglich.
Pathophysiologie und aktuelle Behandlungskonzepte bei ausgewählten Osteonekrosen
Authors: Gatz Matthias , Betsch Marcel , Andruszkow Julia , Quack Valentin , Tingart Markus 
Published: October 2019

ZusammenfassungOsteonekrosen treten sowohl beim heranwachsenden als auch ausgewachsenem Skelett meist an prädisponierenden Lokalisationen mit Bevorzugung der Epiphysen auf. Pathophysiologisch unterscheidet man neben einer idiopathischen Form zwischen einer primär vaskulären (Thromboembolien, Hämoglobinopathien usw.) und einer toxischen (Cortison, Alkohol, Chemotherapeutika usw.) Genese. Unabhängig der Ätiologie resultiert eine Nekrose der Knochentrabekel und des angrenzenden Knochenmarks sowie eine Ödembildung. Durch avaskuläre Umbauvorgänge bildet sich eine Fibrose und mechanisch instabiler Geflechtknochen aus, sodass es im Verlauf zu einer subchrondralen Fraktur und einem Gelenkkollaps kommt. Insbesondere bei Beteiligung großer Gelenke resultieren sekundär arthrotische Deformitäten, sodass insbesondere die Hüftkopfnekrose sowie die fokale subchondrale Osteonekrose und Osteochondrosis dissecans des Knies von klinischer Bedeutung sind. Diagnostisch ist neben der nativ-radiologischen Röntgendiagnostik die Magnetresonanztomographie mit der charakteristischen Darstellung des „Sichelzeichens“ entscheidend. Therapeutisch können als konservative Maßnahmen lediglich periphere Vasodilatatoren oder Bisphosphonate als off-label use Schmerzen reduzieren und die Zeit bis zum Gelenkflächenkollaps verhindern, wohingegen die hyperbare Sauerstofftherapie, die Stoßwellentherapie, Antikoagulanzien und Statine allgemein nicht angewendet werden sollten. Die Standardtherapie in frühen Stadien ist die retrograde Anbohrung mit der Zielsetzung einer Ödementlastung und einer Unterbrechung der Sklerosezone zur Revaskularisation. Weitere operative Maßnahmen wie Umstellungsosteotomien, vaskularisierte Knochentransplantate sowie Knorpelplastiken sind möglich, wobei diese mit dem prothetischem Gelenkersatz konkurrieren.
Association Between Serum C-Peptide Level and Cardiovascular
Autonomic Neuropathy According to Estimated Glomerular Filtration Rate in
Individuals with Type 2 Diabetes
Authors: Chung Jin Ook , Park Seon-Young , Cho Dong Hyeok , Chung Dong Jin , Chung Min Young 
Published: October 2019

Abstract
Objective To investigate the association between serum C-peptide
level and cardiovascular autonomic neuropathy (CAN) in individuals with type
2 diabetes mellitus (DM) according to estimated glomerular filtration rate
(eGFR)
Methods In a cross-sectional study, we examined 939 individuals with
type 2 DM. We measured fasting C-peptide, 2-hour postprandial C-peptide, and
ΔC-peptide (postprandial C-peptide minus fasting C-peptide) levels.
The individuals were classified into 2 groups based on eGFR: individuals
without impaired renal function (eGFR
≥60 ml∙min−1
1.73m−2) and those with impaired renal function (eGFR
<60 ml∙min−1
1.73m−2).
Results Individuals with CAN had lower fasting C-peptide,
postprandial C-peptide, and ΔC-peptide levels in patients both with
and without impaired renal function. Multivariate logistic regression
analyses adjusted for gender, age, and other confounders, including eGFR,
showed that serum C-peptide level was significantly associated with CAN
(odds ratio [OR] per standard deviation increase in the log-transformed
value, 0.67; 95% confidence interval [CI], 0.52–0.87 for
fasting C-peptide, P < 0.01; OR, 0.62; 95% CI,
0.47–0.83 for postprandial C-peptide, P < 0.01; OR, 0.71;
95% CI, 0.54–0.93 for ΔC-peptide, P <
0.05).
Conclusions Serum C-peptide level was negatively associated with CAN
in individuals with type 2 DM independent of eGFR.
An arbitrated quantum signature protocol using rotation and permutation operators
Authors: Wen Kai , Zheng Shihui , Sun Bin 
Published: October 2019

Abstract
The existing improved arbitrated quantum signature (AQS) protocols still have some security problems. First, the security of one AQS protocol is analysed, including existential forgery attack and the signer’s disavowal attack. To resist these attacks, a novel AQS protocol using rotation and permutation operators is proposed. And the analysis shows that the protocol can resist all the known forgery attacks and the signer’s disavowal attacks.
Synergy of the innovation system in the Yangtze River Economic Belt
Authors: Liu Yan , Lei Min , Sun Jie , Zhang Xin 
Published: October 2019

Abstract
On the basis of the principle of order parameters of synergy, a synergy model of the financial-technological-industrial collaborative innovation system in the Yangtze River Economic Belt was constructed. Panel data for the financial structure, technological innovation, and industrial innovation in the Yangtze River Economic Belt for the period from 2011 to 2016 were used to analyze the degree of synergy within each subsystem of the innovation system and between the subsystems and measure the corresponding levels of synergy. The research showed that the financial-technological-industrial subsystems in the Yangtze River Economic Belt were basically in an orderly state, and the Jiangsu subsystem exhibited the best synergy, followed by Shanghai and Zhejiang, whereas that of Yunnan was poor. The overall economic cooperation of the Yangtze River Economic Belt is not ideal, and the level of synergy fluctuates greatly.
Study on the low-frequency forbidden transmission properties of one-dimensional ternary solid-fluid sonic crystals by FEM
Authors: Lu Wei , Xu Baiqiang , Gong Hang , Xu Guidong , Xu Chenguang , Zhang Sai 
Published: October 2019

Abstract
Based on the finite element method (FEM), an acoustic transmission model of onedimensional ternary solid-fluid sonic crystals under the condition of oblique incidence is established. Transmission spectra of acoustic waves with different incident angles and frequencies in sonic crystals are calculated. The results show that two broadband forbidden band gaps exist in the low frequency range within two separated incident angle ranges for the ternary structure, which has one more band gap than the binary solid-fluid structure. By adjusting the solid filling fraction, period and lattice constant of the ternary structure, the angle widths of these two band gaps can be effectively regulated. This work will be of great significance to the design of underwater low-frequency acoustic filters.
Analysis of nonlinear dynamic response of spatial flexible tether system by Symplectic difference scheme
Authors: Wang Qiao , Ding Huaiping , Deng Haihua , Zhang Miao 
Published: October 2019

AbstractThis paper transforms the discrete Langrangian formulation of spatial flexible tether systems to Hamiltonian formulism. The resulting Hamiltonian canonical equations are solved by Symplectic difference scheme. The application of Symplectic difference method for solution of nonlinear tether dynamic problems ensures conservation of system energy, momentum and volume. Two numerical examples are conducted to validate the proposed method, one is the free swing pendulum system and the other one is the three-dimensional circular towed system. The simulation results are compared with theoretical and the existing numerical results. The comparisons demonstrate the proposed Symplectic difference integrator for the Hamiltonian nodal position finite element method is numerically accurate and efficient to predict the dynamic response of spatial flexible tether systems.
Modeling flow in anisotropic porous medium with full permeability tensor
Authors: Cao Jie , Gao Hui , Dou Liangbin , Zhang Ming , Li Tiantai 
Published: October 2019

Abstract
The flow in anisotropic porous medium is significant for the modeling of subsurface fluids transportation. The subsurface porous medium is usually both heterogeneous and anisotropic, caused by the compaction and sedimentations effects on the formation. Full permeability tensor is therefore needed in modeling flow in anisotropic medium. In this research, two widely used finite volume schemes, Two-Point Flux Approximation (TPFA) and Multi-Point Flux Approximation (MPFA), are applied to solve the flow model with a full permeability tensor. The results verified that ignoring anisotropy of the porous medium results in overestimation of the total flux. The TPFA methods have high computational efficiency, but failed to represent the anisotropy. The MPFA scheme takes more CPU time than TPFA for same grid block resolution, but incorporates the anisotropy using a full tensor. The comparison between the results from two methods indicates that ignoring anisotropy results in significant errors in determined flux.
Flange balance application in high speed wind tunnel test of BWB aircraft
Authors: Xu Xin , Liu Dawei , Shi Yujie , Chen Dehua , Cheng Keming 
Published: October 2019

Abstract
In order to improve quality and efficiency of Blended Wing-Body (BWB) aircraft’s high-speed wind tunnel test, while verify the reliability and practicability of flange balance in the test of such a layout aircraft. The specific flange-connected balance of BWB aircraft was designed and processed, which was designed under the limits of aerodynamic load and model interspace size. The comparison test results between the flange balance and the traditional cone balance were obtained by conducting a comparison test in the 2.4-meters transonic wind tunnel. The results show that the flange balance has high measurement accuracy and good correlation with the traditional cone balance. Flange balance meets the requirement of BWB layout aircraft high speed wind tunnel test and has a broad application prospect, so that it could be popularized in the future.
Diagnostics of plasma electron density and collision frequency of fluorescent lamp using microwave transmission diagnostics
Authors: Liu Yutao , Hou Zhongyu 
Published: October 2019

Abstract
According to the propagation characteristics of the microwave in the plasma, the collision frequency and electron density in the plasma can be simultaneously obtained by measuring the attenuation and phase shift. A new method is proposed to diagnose the plasma in the T8 and T4 fluorescent lamps. According to the experimental results, the electron density of the T8 and T4 fluorescent lamps range from 0.8 × 1011/cm
3 to 5.3 × 1011/cm
3 and 1.4 × 1011/cm
3 to 8.1 × 1011/cm
3 respectively. Besides, the collision frequency of T8 and T4 are (2 − 7) × 1010Hz and (2.9 − 7.4) × 1010Hz respectively. This is basically consistent with the diagnostics results of the two-probe diagnostic method. Moreover, the S-parameters simulation results using the measured plasma parameters based on the Drude’s model are also consistent with the experimental results.
Forecasting Chinese outbound tourist to Singapore, Malaysia and Thailand destinations: a study of state space approach
Authors: Jiang Danhua , Liu Jianxu , Sirisrisakulchai Jirakom , Sriboonchitta Songsak 
Published: October 2019

Abstract
This paper aims to forecast the tourism demand of mainland Chinese residents with regard to visiting Singapore, Malaysia and Thailand (SMT) from 2018 to 2022, and examine the factors that influence outbound tourism demand. The empirical results show that income level, tourism price, and substitute price all have an impact on tourism demand, of which income level and substitution price have a positive impact on tourism arrivals; in contrast, tourism price has a negative effect. Afterward, based on the forecasted performance, the TVP-STSM model in state-space form is better than other benchmark models (Linear Regression model, ARIMA model, BSM model, and CSM model). Finally, this study finds the best model to forecast the number of tourists to SMT in the next 5 years. The results show that the largest increase among the three countries goes to Thailand, followed by Singapore and Malaysia; recommendations are also made on the forecasting of trends.
The extreme risk spillovers between the US and China’s agricultural commodity futures markets
Authors: Zhu Qiujing , Tansuchat Roengchai 
Published: October 2019

Abstract
In this study, we investigate the downside and upside risk spillover effects between the same kind of agricultural futures in the Chinese and US markets, taking the value-at-risk (VaR) and conditional value-at-risk (CVaR) as a risk measure, characterized and computed using copula-GARCH approach. We find evidence of a significant positive dependence between the US and Chinese agricultural commodity futures markets. And the empirical results also show that the existence of downside and upside risk spillover effects between variables, especially significant during financial turmoil periods. Market regulators and traders of agricultural futures will benefit by identifying tail dependence and extreme risk spillovers.
Application of cluster analysis and discriminant analysis in quality grading of jadeite red
Authors: Pan Xin , Guo Ying , Liu Ziyuan , Zhang Zikai , Shi Yuxiang 
Published: October 2019

Abstract
A more effective grading standard for jadeite-jade red was established through combining gemology with statistics. 120 jadeite-jade (red) samples were tested by X-Rite SP62 integral spherical spectrophotometer under standard light source D65 to quantify the lightness (L*), hue (hab°) and chroma (Cab*) of jadeite-jade red based on CIE 1976 L*a*b* uniform color space theory. K-Means clustering analysis method in SPSS 22.0 statistical analysis software was used to grade the color of red jadeite-jade. Fisher discriminant analysis method was used to verify the feasibility of the classification and to find an objective and effective color grade evaluation method. Finally, the jadeite-jade red was divided into five grades: Fancy Vivid, Fancy Deep, Fancy Intense, Fancy dark and Fancy.
Food safety and environmental risks based on meat and dairy consumption surveys
Authors: Djekic I , Petrovic J , Tomasevic I 
Published: October 2019

Abstract
This paper gives an overview of the possibilities of using meat and dairy consumption studies in food safety and environmental risk scenarios. For both types of riskbased scenarios, common denominators are consumption patterns such as frequency and quantity of consumed food, demographic profile of consumers and food safety hazard or environmental impact of a specific type of food. This type of data enables development of simulation models where the Monte Carlo method is considered as a useful mathematical tool. Synergy of three dimensions – field research used in consumption studies, advanced chemometric tools necessary for quantifying chemical food safety hazards or environmental impacts and simulation models – has the potential to adapt datasets from various sources into useful food safety and/or environmental information.
Precision livestock farming in the context of meat safety assurance system
Authors: Nastasijevic I , Brankovic Lazic I , Petrovic Z 
Published: October 2019

Abstract
The food chain continuum `from farm to fork` should be managed to provide the appropriate level of consumer protection. Healthy animals are the essential precondition for obtaining a safe food supply. A science-based risk assessment includes the information about prevalence and concentration of major public health hazards of zoonotic origin (Salmonella, Campylobacter, Listeria monocytogenes, Yersinia, Verotoxin-producing E. coli/VTEC) and chemical contaminants (residues of veterinary drugs, dioxins, mycotoxins) in all modules along the food (meat) chain: farm-transport-slaughterhouse-meat processing-distribution-retailconsumers. The effective monitoring of biological or behavioural symptoms related to animal health and welfare can be achieved by Precision Livestock Farming (PLF). PLF emerged as a farm management approach based on information and communication technology (ICT). It can enable the early disease detection system using electronic information transfer from biosensors, in optimising animal health, production and management processes on farm. PLF can deliver added value to the integrated meat safety assurance system (MSAS) by providing real-time evidence of animal health and welfare status. This will strengthen understanding of all three major aspects of MSAS that must be monitored: biological hazards (farm-slaughterhouse continuum), animal health and welfare (Food Chain Information (FCI) quality and flow), and contaminants (prioritisation in monitoring based on FCI information).
Perspectives in meat processing
Authors: Vasilev D , Stajkovic S , Karabasil N , Dimitrijevic M , Teodorovic V 
Published: October 2019

Abstract
Meat technology includes all steps from animal handling and slaughtering to production of different meat products. During animal handling, special attention is paid to animal welfare, not only to protect animals from suffering but also because of animal welfare’s importance for meat quality. The oldest processing methods (chilling, freezing, salting, smoking and drying) are being readjusted with respect to equipment and consumer’s health issues. Special attention is given to preservation of meat’s nutritive value (milder heat treatment) and health promoting properties of the products (functional foods). Novel methods (irradiation, high pressure, pulsed electric field, pulsed light and cold plasma) struggle with some issues such as acceptance by consumers, expensive equipment and effects on food’s sensory properties. Along with novel products, demand for traditional meat products is still increasing which requires the the uniqueness and quality of these products to be preserved, along with increased production capacity.
The influence of cooking methods and juniper essential oil on lipid oxidation in pork chops
Authors: Ivic M , Tomovic V , Jokanovic M , Skaljac S , Sojic B 
Published: October 2019

Abstract
In this research, the effects of three cooking methods (boiling–vacuum bag, boiling–plastic bag and baking) on the lipid oxidation and overall sensory acceptability of pork chops marinated with and without juniper essential oil were investigated. The thiobarbituric acid reactive substance content was affected by both marinating and cooking methods. Pork chops from juniper essential oil marinade had lower thiobarbituric acid reactive substance values throughout the marinating and two cooking methods (boiling–plastic bag and baking) in comparison to their control counterparts. The pork chops with juniper oil, regardless of cooking method, were evaluated with significantly higher scores for overall acceptability than all analysed control pork chops.
Characteristics of textured soy protein products as raw materials in the meat industry
Authors: Jovanovic I , Novic G , Jovanović M , Vujacic Lj 
Published: October 2019

Abstract
Soy protein belongs to the group of whole proteins and is recognised as a high quality plant protein. In the meat industry, soy-based protein products are used as functional additives (emulsifiers, stabilizers) or as good nutritional fillers, i.e. replacement for part of the meat in a recipe. They can be added in dry or in hydrated states (textured soy products). As a result of regular product control conducted for the company Sojaprotein, data on protein content and water hydration capacity obtained between 2016 and 2018 for textured soy protein SOPROTEX–N, and textured soy concentrate TRADCON T, both minced products, are presented in this paper.