bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sildenafil Protects Endothelial Cells From Radiation-Induced Oxidative Stress
Authors: Wortel R.C. , Mizrachi A. , Li H. , Markovsky E. , Enyedi B. , Jacobi J. , Brodsky O. , Cao J. , Lippert A.R. , Incrocci L. , Mulhall J.P. , Haimovitz-Friedman A. 
Published: October 2019

AbstractIntroductionThe etiology of radiation-induced erectile dysfunction (ED) is complex and multifactorial, and it appears to be mainly atherogenic.AimTo focus on vascular aspects of radiation-induced ED and to elucidate whether the protective effects of sildenafil are mediated by attenuation of oxidative stress and apoptosis in the endothelial cells.MethodsBovine aortic endothelial cells (BAECs), with or without pretreatment of sildenafil (5 μM at 5 minutes before radiation), were used to test endothelial dysfunction in response to external beam radiation at 10–15 Gy. Generation of reactive oxygen species (ROS) was studied. Extracellular hydrogen peroxide (H2O2) was measured using the Amplex Red assay and intracellular H2O2 using a fluorescent sensor. In addition, ROS superoxide (O2•-) was measured using a O2•- chemiluminescence enhancer. Both H2O2 and O2•- are known to reduce the bioavailability of nitric oxide, which is the most significant chemical mediator of penile erection. Generation of cellular peroxynitrite (ONOO−) was measured using a chemiluminescence assay with the PNCL probe. Subsequently, we measured the activation of acid sphingomyelinase (ASMase) enzyme by radioenzymatic assay using [14C-methylcholine] sphingomyelin as substrate, and the generation of the proapoptotic C16-ceramide was assessed using the diacylglycerol kinase assay. Endothelial cells apoptosis was measured as a readout of these cells’ dysfunction.Main Outcome MeasuresSingle high-dose radiation therapy induced NADPH oxidases (NOXs) activation and ROS generation via the proapoptotic ASMase/ceramide pathway. The radio-protective effect of sildenafil on BAECs was due to inhibition of this pathway.ResultsHere, we demonstrate for the first time that radiation activated NOXs and induced generation of ROS in BAECs. In addition, we showed that sildenafil significantly reduced radiation-induced O2•- and as a result there was reduction in the generation of peroxynitrite in these cells. Subsequently, sildenafil protected the endothelial cells from radiation therapy-induced apoptosis.Strengths and LimitationsThis is the first study demonstrating that single high-dose radiation therapy induced NOXs activation, resulting in the generation of O2•- and peroxynitrite in endothelial cells. Sildenafil reduced ROS generation by inhibiting the ASMase/ceramide pathway. These studies should be followed in an animal model of ED.ConclusionsThis study demonstrated that sildenafil protects BAECs from radiation-induced oxidative stress by reducing NOX-induced ROS generation, thus resulting in decreased endothelial dysfunction. Therefore, it provides a potential mechanism to better understand the atherogenic etiology of postradiation ED.
Transcendental Monsters, Animism and the Critique of Hyperobjects
Authors: Bradley Joff P.N. 
Published: October 2019

AbstractThis transversal and transilient thought-experiment explores the application and significance of Japanese animism for environmental education and environmental philosophy. Through the exploration of indigenous knowledge found in Japanese folklore and Japanese Buddhism, the thought-experiment offers a critique of a certain strand of contemporary fatalistic and nihilistic thinking regarding the Anthropocene. At its simplest it questions the trend toward mysticism and obfuscation in environmental education and demands a response to the environmental crisis precisely through reason and rationality. How shall this be undertaken? On one level, the hauntings of 妖怪 (Yōkai) and 幽霊 (Yūrei) in Japanese folklore shall act as a prism through which to understand the impact of the fantastical on the contemporary imagination, and on another level, I shall critique the fantastical as such to question the so-called inaccessibility of the hyperobject (Morton, 2014), which in the end leaves us despairingly passive and without the possibility of response. It is in the work of the Japanese philosopher 井上円了 (Inoue Enryō) and especially his defence of Western Enlightenment beliefs during Japan’s modernisation period (1868–1912) that a curious method and heuristic tool is found that may be used to address not only the problem of mystification in Japanese philosophy but also the obfuscation of the ecological object of recent Western thought. Seemingly sacrilegiously, it is through reason and at the limits of the rational that one may approach the hyperobject-in-itself, which is to say, the unfathomable as such.
Modern Slavery in Global Supply Chains: Can National Action Plans on Business and Human Rights Close the Governance Gap?
Authors: HAMPTON Diane Bulan 
Published: October 2019

AbstractFollowing the 2011 endorsement of the UN Guiding Principles on Business and Human Rights (UNGPs), states have begun to implement National Action Plans (NAPs) to operationalize the UNGPs. Using a case study approach and applying a conceptual framework for polycentric governance, this article aims to provide an early assessment of the effectiveness of NAPs adopted by the United Kingdom and the United States to combat one of the worst human rights abuses in global supply chains: modern slavery. This study demonstrates that both NAPs contain elements addressing the governance gaps surrounding modern slavery, such as enacting new laws, adapting existing regulations, strengthening multi-stakeholder mechanisms for business accountability, and promoting innovation. However, it is argued that the NAPs themselves were not the catalysts for the majority of these measures. This article concludes that states should optimize the five characteristics of polycentric governance outlined in this study to improve the relevance and effectiveness of NAPs as drivers of change.
Testing for N-methyl-d-aspartate Receptor Autoantibodies in Clinical Practice
Authors: Brooks John , Yarbrough Melanie L. , Bucelli Robert C. , Day Gregory S. 
Published: October 2019

Abstract:Background:The diagnosis of anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis relies on the detection of NMDAR IgG autoantibodies in the serum or cerebrospinal fluid (CSF) of symptomatic patients. Commercial kits are available that allow NMDAR IgG autoantibodies to be measured in local laboratories. However, the performance of these tests outside of reference laboratories is unknown.Objectives:To report an unexpectedly low rate of NMDAR autoantibody detection in serum from patients with anti-NMDAR encephalitis tested using a commercially available diagnostic kit in an exemplar clinical laboratory.Methods:Paired CSF and serum samples from seven patients with definite anti-NMDAR encephalitis were tested for NMDAR IgG autoantibodies using commercially available cell-based assays run according to manufacturer’s recommendations. Rates of autoantibody detection in serum tested at our center were compared with those derived from systematic review and meta-analyses incorporating studies published during or before March 2019.Results:NMDAR IgG autoantibodies were detected in the CSF of all patients tested at our clinical laboratory but not in paired serum samples. Rates of the detection were lower than those previously reported. A similar association was recognized through meta-analyses, with lower odds of NMDAR IgG autoantibody detection associated with serum testing performed in nonreference laboratories.Conclusions:Commercial kits may yield lower-than-expected rates of NMDAR IgG autoantibody detection in serum when run in exemplar clinical (nonreference) laboratories. Additional studies are needed to decipher the factors that contribute to lower-than-expected rates of serum positivity. CSF testing is recommended in patients with suspected anti-NMDAR encephalitis.
Persistence probability of a random polynomial arising from evolutionary game theory
Authors: Can Van Hao , Duong Manh Hong , Pham Viet Viet Hung 
Published: October 2019

AbstractWe obtain an asymptotic formula for the persistence probability in the positive real line of a random polynomial arising from evolutionary game theory. It corresponds to the probability that a multi-player two-strategy random evolutionary game has no internal equilibria. The key ingredient is to approximate the sequence of random polynomials indexed by their degrees by an appropriate centered stationary Gaussian process.
Sums of standard uniform random variables
Authors: Mao Tiantian , Wang Bin , Wang Ruodu 
Published: October 2019

AbstractIn this paper, we analyse the set of all possible aggregate distributions of the sum of standard uniform random variables, a simply stated yet challenging problem in the literature of distributions with given margins. Our main results are obtained for two distinct cases. In the case of dimension two, we obtain four partial characterization results. For dimension greater than or equal to three, we obtain a full characterization of the set of aggregate distributions, which is the first complete characterization result of this type in the literature for any choice of continuous marginal distributions.
Analysis of a network’s asymptotic behavior via its structure involving its strongly connected components
Authors: Treur Jan 
Published: October 2019

AbstractIn this paper, it is addressed how network structure can be related to asymptotic network behavior. If such a relation is studied, that usually concerns only strongly connected networks and only linear functions describing the dynamics. In this paper, both conditions are generalized. A couple of general theorems is presented that relates asymptotic behavior of a network to the network’s structure characteristics. The network structure characteristics, on the one hand, concern the network’s strongly connected components and their mutual connections; this generalizes the condition of being strongly connected to a very general condition. On the other hand, the network structure characteristics considered generalize from linear functions to functions that are normalized, monotonic, and scalar-free, so that many nonlinear functions are also covered. Thus, the contributed theorems generalize the existing theorems on the relation between network structure and asymptotic network behavior addressing only specific cases such as acyclic networks, fully, and strongly connected networks, and theorems addressing only linear functions. This paper was invited as an extended (by more than 45%) version of a Complex Networks’18 conference paper. In the discussion section, the differences are explained in more detail.
The lower–middle Viséan boundary interval in the Palaeotethys: refinements for the foraminiferal zonal schemes
Authors: Cózar Pedro , Vachard Daniel , Somerville Ian D. , Izart Alain , Coronado Ismael 
Published: October 2019

AbstractA new foraminiferal subzone (Cf5α or MFZ12α) in between the classical foraminiferal zonal biozones is characterized by the first occurrence ofArchaediscusat concavus stage, primitive species ofPojarkovella, as well as the firstEndothyranopsiss.s. This interval is represented in England, France and Morocco (in the western Palaeotethys) and in South China, and more widely in Iran (in the eastern Palaeotethys), where it is partly similar to the MFZ11B subzone defined by previous authors. The position of this new biozone within the Livian or Holkerian substages suggests that it has to be considered as part of the middle Viséan substage. We therefore propose the abandonment of the notation MFZ11B, which includes lower Viséan rocks, and the subdivision of the middle Viséan zones MFZ12 and Cf5 into two subzones MFZ12α or Cf5α, and MFZ12β or Cf5β, with the latter subzone containing the classical Livian–Holkerian foraminiferal guidesPojarkovella nibelis and Koskinotextularia. Furthermore, the lower Viséan MFZ11 zone can be subdivided in most Palaeotethyan basins into three subzones: a lower MFZ11α subzone (characterized by the first occurrence ofUralodiscus rotundus, as well as most species ofGlomodiscus); a middle MFZ11β subzone (characterized by the first occurrence ofArchaediscusat involutus stage andConilidiscus); and an upper MFZ11γ subzone (characterized by the first occurrence ofNodosarchaediscus,Consobrinellopsis and Lituotubella).
An integrative analysis of sibling influences on adult children's care-giving for parents
Authors: Vergauwen Jorik , Mortelmans Dimitri 
Published: October 2019

AbstractThe extent to which, and the reasons why, children help to care for their parents are examined in an extensive range of literature. Although care for parents essentially takes place in parent–child dyads, many of these studies acknowledge that the amount of care a child gives is generally the outcome of collective decisions in multiple-child families. However, to our knowledge, no research in Europe enhances our understanding of how sibling characteristics influence an individual child's care-giving. Using data for 14 European countries from the Survey of Health, Ageing and Retirement in Europe, the present study relates pre-care-giving sibling characteristics to children's subsequent start of giving care. This longitudinal approach allows correction for the endogenous nature of time-changing predictors. The analysis demonstrates that daughters start to care more often when they have brothers instead of sisters. This pattern of gendered intergenerational care particularly applies to southern European countries. We also observe that both pre-care-giving parent–sibling frequency of contact and geographic distances predict children's care-giving transition strongly. Children who are closer to their parents than siblings in terms of contact and proximity have higher odds of care-taking. Finally, being the only child without a job enhances the start of care-giving as well. The results suggest that sibling characteristics are an important factor in explaining intergenerational care differences between children in Europe.
Flexibility of frequent clause openers in talk-in-interaction:Det‘it, that’ andså‘then’ in the prefield in Danish
Authors: Puggaard Rasmus 
Published: October 2019

AbstractThrough in-depth analysis of the use ofdet‘it, that’ andså‘then’ occupying the first clausal position (the prefield) in Danish talk-in-interaction, this paper investigates how speakers use highly flexible linguistic elements to their advantage when commencing clauses in real time. These particular words are useful when occupying the prefield, because their flexible nature means that they can be used even when speakers do not have a full format ready for the carrier clause, as long as they have some idea of the interactional purpose of the clause and its information structural prerequisites. The dominating frequency of the most frequent clause openers goes largely unmentioned in previous accounts of the prefield, and the use ofdet‘it, that’ andså‘then’ challenges the popular notion that the textually unmarked prefield is also the grammatical subject of the carrier clause.
Actual and apparent change in Brazilian Portuguese wh-interrogatives
Authors: Rosemeyer Malte 
Published: October 2019

ABSTRACTPrevious studies on the diachrony of wh-interrogation in Brazilian Portuguese have observed a replacement process of ex-situ-wh interrogatives by cleft-wh and in-situ-wh interrogatives in the twentieth century. The present study analyzes almost 19,000 wh-interrogatives from a corpus of theater plays dated between 1800 and 2016, demonstrating that not all of these frequency changes constitute actual change. The increase in the usage frequency of several types of wh-interrogatives is partially or entirely due to changes in the degree of orality of theater plays, or changes in word order. Moreover, only some of these changes can be characterized as changes from below, that is, changes in which high-orality texts are affected by the frequency increase first. This notion is also relevant for functional change in wh-interrogatives. Over time, the use of cleft-wh and in-situ-wh interrogatives spread from contexts in which the proposition is highly accessible to low-accessibility contexts. For cleft-wh, this change is moderated by orality, again indicating change from below.
The noun phrase and the ‘Viking Hypothesis’
Authors: Crisma Paola , Pintzuk Susan 
Published: October 2019

ABSTRACTIn this article we use the syntax of the noun phrase to evaluate two competing hypotheses: the traditional account, that Middle English is a West Germanic language with Old English as its immediate ancestor, and Emonds and Faarlund's (2014) proposal, that Middle English is a North Germanic language, the direct descendant of Old Norse. The development of nominal syntax shows that the Middle English noun phrase can be derived only from Old English, not from Old Norse. We examine six nominal characteristics; in each case, we find in Middle English exactly the construction that one would expect given the nominal syntax of previous Old English stages. The evidence from Old Norse shows that, although some of the same constructions did develop in the same way in the attested Norse varieties, the development occurred only at a later stage, too late to have affected the syntax of Middle English.
Changes in nutrient and food group intakes among children and women participating in the Special Supplemental Nutrition Program for Women, Infants, and Children: findings from the 2005–2008 and 2011–2014 National Health and Nutrition Examination Surveys
Authors: Zimmer Meghan C , Vernarelli Jacqueline A 
Published: October 2019

AbstractObjective:To use nationally representative data to evaluate changes in nutrient and food intakes among children and women participating in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) before v. after implementation of the 2009 food package revisions.Design:Cross-sectional study using National Health and Nutrition Examination Survey (NHANES) data. NHANES survey cycles were pooled to assess nutrient/food group intakes among household WIC participants pre- (2005–2008) v. post- (2011–2014) implementation of the 2009 food package revisions.Setting:Information regarding WIC participation and 24 h diet recalls were collected at NHANES examination.Participants:Children 24–59 months old and women 19–50 years of age in households receiving WIC benefits in the NHANES 2005–2008 and 2011–2014.Results:Comparison of WIC participants’ dietary intake pre- and post-revision demonstrated changes in mean population intakes of both nutrients and food groups. The food package revisions were associated with increased intakes of fibre (P = 0·004 children, P = 0·013 women) and whole grains (P = 0·001 children, P = 0·087 women). For children only, vegetable intake shifted to higher consumption of legumes (P = 0·013) and decreased intake of starchy vegetables (P = 0·042). No significant changes were observed for dairy or fruit intake of children or women.Conclusions:The study provides insight to what goals of the package revisions were achieved. The findings can inform future food package revisions.
A literature review of the role of brachytherapy in the management of early-stage breast cancer
Authors: Thorpe Rebecca , Drury-Smith Heather 
Published: October 2019

AbstractBackground:This review evaluates whether brachytherapy can be considered as an alternative to whole breast irradiation (WBI) using criteria such as local recurrence rates, overall survival rates and quality of life (QoL) factors. This is an important issue because of a decline in local recurrence rates, suggesting that some women at very low risk of recurrence may be incurring the negative long-term side effects of WBI without benefitting from a reduction in local recurrence and greater overall survival. As such, the purpose of this literature review is to evaluate whether brachytherapy is a credible alternative to external beam radiation with a particular focus on the impact it has on patient QoL.Methods:The search terms used were devised by using the Population Intervention Comparison Outcome framework, and a literature search was carried out using Boolean connectors and Medical Subject Headings in the PubMed database. The resultant articles were manually assessed for relevance and appraised using the Scottish Intercollegiate Guidelines Network tool. Additional papers were sourced from the citations of articles found using the search strategy. Government guidelines and regulations were also used following a manual search on the National Institute for Health and Care Excellence website. This process resulted in a total of 30 sources being included as part of the review.Results:Three types of brachytherapy were the foundation for the majority of the papers found: interstitial multi-catheter brachytherapy, intra-cavity brachytherapy and permanent seed implantation. The key themes that arose from the literature were that brachytherapy is equivalent to WBI both in terms of 5-year local recurrence rates and overall survival rates at 10–12 years. The findings showed that brachytherapy was superior to WBI for some QoL factors such as being less time-consuming and equal in terms of others such as breast cosmesis. The results did also show that brachytherapy does come with its own local toxicities that could impact upon QoL such as the poor breast cosmesis associated with some brachytherapy techniques.Conclusion:In conclusion, brachytherapy was deemed a safe or acceptable alternative to WBI, but there is a need for further research on the long-term local recurrence rates, survival rates and quality of life issues as the volume of evidence is still significantly smaller for brachytherapy than for WBI. Specifically, there needs to be further investigation as to which patients will benefit from being offered brachytherapy and the influence that factors such as co-morbidities, performance status and patient choice play in these decisions.
NAFTA 2.0: The Greenest Trade Agreement Ever?
Authors: LAURENS NOEMIE , DOVE ZACHARY , MORIN JEAN FREDERIC , JINNAH SIKINA 
Published: October 2019

AbstractThe renegotiation of what US President Trump called ‘the worst trade deal ever’ has resulted in the most detailed environmental chapter in any trade agreement in history. The USMCA mentions dozens of environmental issues that its predecessor, the North American Free Trade Agreement (NAFTA), overlooked, and in line with contemporary US practice, brings the vast majority of environmental provisions into the core of the agreement, and subjects these provisions to a sanction-based dispute settlement mechanism. It also jettisons two controversial NAFTA measures potentially harmful to the environment. However, this paper argues that the USMCA only makes limited contributions to environmental protection. It primarily replicates most of the environmental provisions included in recent agreements, and only introduces three unprecedented environmental provisions. Moreover, it avoids important issues such as climate change, it does not mention the precautionary principle, and it scales back some environmental provisions related to multilateral environmental agreements.