bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectrophotometric determination of sotalol in tablets
Authors: Zhuk Y. M. , Vasyuk S. O. 
Published: March 2019

In this investigation a visible spectrophotometric method for the determination of sotalol based on the absorbance of colored product of the reaction between sotalol hydrochloride and bromcresol purple in acetone medium at 399 nm measurement was developed. The optimal conditions for the quantitative determination of sotalol hydrochloride in the content of pharmaceutical drugs were established. The stoichiometric relationship coefficients between sotalol hydrochloride and bromcresol purple were determined. The validation of the worked out procedure on such validated characteristics as linearity, precision, accuracy and robustness was carried out.
The aim. To develop a highly sensitive, easy to use, cost-effective and valid method for quantitative determination of sotalol hydrochloride in dosage forms.
The analysis method. Visible spectrophotometry.
The analytical parameters such as molar absorptivity, Beer’s law limits and Sandell’s sensitivity values were calculated. The developed methods give the result with repeatability sufficient for dependable determination the investigated substance in pharmaceutical formulations. Accuracy established by analyte addition technique. Determined factors that influence on the absorbance value: reagent quantity and timing stability. Sample solutions stable during 30 min. Addition to sample solution ± 10% bromcresol purple solution is not change the absorbance value. Established that reaction between sotalol hydrochloride and bromcresol purple proceeds in acetone medium at room temperature. Molar absorption coefficient is 2,62∙103.
Investigation of quality indicators and studying the stability of “Propolis-AK” gel for the treatment of acne disease
Authors: Tykhonov А. I. , Yarnykh T. G. , Bobro S. G. , Shpychak O. S. 
Published: March 2019

In modern conditions, the incidence of acne, which is a polymorphic multifactorial disease of the sebaceous glands of the skin, has a tendency to significant growth. Localization of lesions on the face in almost all patients indicates the fact that acne has an effect on their psycho-emotional sphere and social adaptation, which makes this problem urgent and indicates the feasibility of creating new effective domestic medicines for treating this pathology.
The aim of the work was to conduct research on the investigation of quality indicators and studying the stability of «Propolis-AK» gel of anti-inflammatory and antimicrobial action for the treatment of acne disease.
The objects of research were model test-samples of «Propolis-AK» gel, for which were developed methodic for analyzing the qualitative composition and quantitative content of the active substances – propolis phenolic hydrophobic drug (PPHD) and azelaic acid (AA) in this dosage form, comprehensively allowing to evaluate the quality and criteria for the stability of the gel during the entire storage period for the following indicators: description, identification, homogeneity, tightness of the container, pH, package contents, microbiological purity, quantification. In addition, the requirements for packaging, labeling, transportation, storage conditions and shelf life were included in the draft of quality control methods.
According to the results of the study of organoleptic and physical-chemical parameters of the developed «Propolis-AK» gel during storage at two temperature conditions (8‒15 °C and 15‒25 °C), it was found that the test samples of the gel under study remained fairly stable according to the studied indicators for 2 years and 3 months, which allows us to recommend a shelf life of 2 years at room temperature in aluminum tubes for the studied gel. According to the results of research, a specification for «Propolis-AK» gel for external use was developed as a component of the draft of quality control methods for the studied medicine.
Studies have been conducted to establish the main indicators and methods of quality control of the developed «Propolis-AK» gel for the treatment of acne disease. According to the results of the tests, a “Specification” was developed, which was included in the draft of quality control methods and experimentally proved the stability of «Propolis-AK» gel prepared in pharmaceutical and industrial conditions for a prescribed shelf life of 24 months when stored in aluminum tubes with an internal lacquer coating in a cool place (8‒15 °C) and at room temperature (15‒25 °C).
HPLC-determination of active components in dietary supplement «L-CARNITINE smart»
Authors: Voitiuk O. D. , Yegorova A. V. , Scrypynets YU. V. , Kashutskуy S. N. , Kluchnik O. G. , Umetskaya I. V. 
Published: March 2019

Dietary supplements are compositions of biologically active substances intended for consumption with food or addition to food products for the purpose of optimization of metabolic processes and functions of the human body. The dietary supplements include: vitamins, trace elements, amino acids, enzymes, proteins, probiotics, oils that can provide antioxidant, detoxifying, immunomodulatory, adaptogenic effects, etc.
Detection of physiologically active components in dietary supplements is a difficult task and requires the use of modern highly informative research methods. One of the most powerful and versatile methods of determination is the method of high performance liquid chromatography (HPLC), combining the selective separation of the studied mixtures and high sensitivity.
The purpose of this study was to develop a simple, rapid and selective method for determining ascorbic acid and L-carnitine L-tartrate in a multicomponent dietary supplement, produced in the form of sachets, using HPLC with spectrophotometric detection.
The object of the study is the dietary supplement «L-CARNITINE smart», powder for oral solution of 16 g each in a sachet (INTERСHЕM). For the quantitative determination of the applied method of high-performance liquid chromatography. Chromatography was performed on an Agilent 1260 Infinity 2D LC System (USA) liquid chromatograph with a UV detector.
The optimal conditions for the analysis have been experimentally determined: the type of sorbent, the composition of the eluent and its gradient, the wavelength and the detection time for ensuring the release of all components (including auxiliary substances) from the column, selective separation of ascorbic acid, potassium acesulfame and L-carnitine L-tartrate, minimization analysis time. The method has been validated according to the following parameters: specificity, linearity, accuracy, limit of quantitation.
Synthesis and establishment of physico-chemical constants 2-(5-( chinoline -2-il, 2-hydroxyquinoline-4-іл)-4-R1-1,2,4-triazole-3-ілтіо) acetate acids and their esther
Authors: Kaplaushenko Т. М. , Panasenko О. І. , Samelyuk Y. G. 
Published: March 2019

The large interest in the plan of search biologically of active agents is caused by the heterocyclic system of 1,2,4-triazole, due to high biological activity, and by the low indexes of toxicness, that inherent it to the structural analogues. Today in medical practice the derivatives of 1,2,4-triazole are used as high-efficiency antioxidants, cytostatic antimycotic agent , antidepressants and others.
Literary information testify that among connections, representatives derivative of 3-tio-1,2,4-triazole range condensed with heteryl carboxylic acid, and their derivatives, find matters with the wide spectrum of biological action.
The primary purpose of this work is continuation of synthetic researches 5-(chinoline-2-il, 2-hydroxyquinoline-4-il)-4-R1-1,2,4-triazole-3-tion, namely synthesis of new 2-(5-(chinolin-2-il, 2-hydroxyquinoline-4-il)-4-R1-1,2,4-triazole-3-iltio) acetate acids, their esteriv and establishment for the new structural derivatives of physical and chemical constants, confirmation of structure and individuality.
On the basis of purposeful synthesis was received 10 new, connections derivatives of 1,2,4-triazole not described in literature, that contain the kernels of triazole`s cycle of chinole in a 5 position, or 2- hydroxyquinoline deputies, namely 2-(5-(chinoline-2-il, 2-hydroxyquinoline-4-il)-4-R1-2,4-dihydro-3Н-1,2,4-triazole-3-iltio) acetate acids and their esteras. For the synthesized connections by the modern physical and chemical methods of analysis their structure is well-proven, and physical and chemical constants are set.
Structure of synthesized esteriv 2-(5-(quinoline-2-il, 2-hydroxyquinoline-4-il)-4-R1-1,2,4-triazole-3-iltio) of acetate acids is confirmed the complex use of element analysis and ICh-spectrophotometry.
Development and validation of the method for determination of encapsulation efficiency of cytochrome c in liposomes
Authors: Katsai O. G. , Prokhorov V. V. , Grigorieva G. S. , Krasnopolsky Yu. M. 
Published: March 2019

A strategic pathway in creating high-potent medical products is with targeted therapeutic systems that are based on nanoparticles of various structure. Such particles are capable of providing a targeted effect and an increase in bioavailability of the medical products. A special place among modern targeted drug delivery systems is held by liposomal nanoparticles which have apparent advantages over nanoparticles of an another type The problem number one for pharmacy lies in developing specific methods of control of nanosize drug delivery systems.
This research is dedicated to the development and validation of a technique for determining encapsulation efficiency of cytochrome C in liposomes.
The subject of research comprised the obtained liposomal form of cytochrome C, placebo emulsion, and cytochrome C solution. The research was conducted in compliance with the ICH and FDA requirements and recommendations in relation to the development of HPLC methods of control of liposomal preparations.
A method has been developed to enable the determination of encapsulation efficiency of cytochrome C in liposomal preparations and to allow for identifying the composition of liposomal nanoparticles of cytochrome C. This HPLC method has been validated in terms of specificity, limit of detection, and robustness in compliance with the recommended criteria. The technique may find its application in quality control of liposomal form of cytochrome C and in control points manufacturing process.
Research of acute toxicity of the drug HEXIA
Authors: Karbovskyy V. L. , Shevchuk I. A. , Kurkina O. V. , Makovska T. Ye. 
Published: March 2019

Diseases of the genitourinary system caused by pathogenic and potentially pathogenic microorganisms, which result into disbiosis of urinary organs, remain an urgent problem of dermatovenereology, gynecology and urology, despite the fact that there is a significant number of available and new medicines to treat them.
The aim of the work was to determine the safety of the preparation Hexia within experiments on animals.
The acute toxicity of Hexia has been determined on 20 adult female laboratory rats under the conditions of hourly intravaginal administration of the preparation with a dose of 70 mg/kg during 12 hours, as well as on 20 female laboratory rats and 20 female laboratory mice with a single intragastric administration in a dose of 145 mg/kg. The assessment of the impact of the preparation studied was performed on the basis of the following parameters: a) mortality (terms of death of animals in each group, on a daily basis); b) assessment of toxicity development (on a daily basis), including an assessment of the visual environment of the area of injection (the presence of irritation, redness, edema); c) dynamics of body weight changes (in the initial state, on the 4th, 7th and 14th day after application); d) macroscopy of internal organs, mass coefficients of internal organs within rats (on the 14th day).
It has been found that intravaginal application and a single intragastric administration of the preparation Hexia in the form of pessaries, which contain chlorhexidine digluconate, does not result into death of rats and mice, brings no effect on body weight gain, integrative parameters of the functional state of laboratory animals as well as on the relative mass of internal organs, which implies the absence of significant toxic effect of the preparation. Thus, the results of the studies conducted indicate that the median lethal dose for Hexia in case of intravaginal application to rats or intragastric administration to rats and mice is beyond the rate of 500 mg/kg. According to the toxicological classification of substances Hexia belongs to the IV class of toxicity – low toxic substances.
Risk Management of Process Moving from Traditional to Agile Software Development
Authors: Mupitra Byan Haqi 
Published: March 2019

Agile programming is the popular software project development method in this era. Many company moving from Traditional software development to agile software development. They move to agile to reduce delivery time, user gap and improve quality. When use traditional method, we usually find big gap when we deliver to user. The solution of this problem is agile method. In Agile, we frequently come to users to tell them what we have done to their requirements. So the gap is not too big and we can solve it fast. But moving to agile software development is not easy. There are some risks when we move to new method. The data for this study were drawn from PT. XYZ. This company trying to move from traditional method into agile method. This company wants to move of the development method in all business units. The notion of this paper is to propose the risk management when company moving their method from Traditional into Agile software development based on study PT XYZ.
HUBUNGAN PENGETAHUAN DAN SIKAP IBU HAMIL DENGAN KEJADIAN KEHAMILAN RESIKO TINGGI DI PUSKESMAS PURWOYOSO KOTA SEMARANG
Authors: Kusumastuti Mirtaria , Rochmayani Dewi Sari , Zulaika Chusnul 
Published: March 2019

Kehamilan yang resiko tinggi akan menghadapi berbagai permasalahan yang dapat mengganggu proses persalinan. Data dari SDKI 2012 AKI di Indonesia adalah 359/ 100.000 kelahiran hidup. Tujuan dalam penelitian ini untuk mengetahui apakah ada hubungan pengetahuan dan sikap ibu hamil dengan kejadian kehamilan resiko tinggi di Puskesmas Purwoyoso Kota Semarang.Jenis penelitian ini studi kuantitatif dengan desain penelitian non experimental, dan tergolong dalam penelitian observasional survey. Populasi dalam penelitian ini sejumlah 50 ibu hamil. Sampel penelitian ini total populasi. Analisa data dengan analisis univariat dan analisis bivariat dengan menggunakan analisis tabulasi silang.Hasil penelitian menunjukkan tingkat pengetahuan cukup (48 %), sikap responden yang setuju dalam memeriksakan kehamilannya (32%). Hasil uji korelasi spearman rank menunjukkan tidak ada hubungan antara pengetahuan ibu hamil dengan kejadian kehamilan resiko tinggi (rs = - 0,06 dan p = 0,965), dan ada hubungan sikap ibu hamil dalam memeriksakan kehamilan dengan kejadian kehamilan resiko tinggi (rs = 0,339 dan p = 0,016). Perlu penelitian lebih lanjut dengan metode kualitatif tentang pengetahuan dan sikap ibu hamil terhadap kejadian kehamilan resiko tinggi agar dapat diungkap informasi yang lebih lengkap dan komprehensif.Kata Kunci : pengetahuan, sikap, kehamilan resiko tinggi RELATED KNOWLEDGE AND ATTITUDE OF PREGNANT WITH HIGH RISK PREGNANCY INCIDENCE HEALTH IN PURWOYOSO SEMARANGHigh-risk pregnancies will encounter various problems that can interfere with the childbirth process. SDKI 2012 MMR in Indonesia is 359 / 100,000 live births. The goal in this study to determine whether there is a relationship of knowledge and attitude of pregnant with high risk pregnancy incidence Health in Purwoyoso Semarang.This type of research is a quantitative study with a non-experimental research design, and classified in observational research survey. The population in this study a number of 50 pregnant. The research sample is total population. Analysis of the data by univariate and bivariate analysis using cross tabulation analysis.The results showed sufficient level of knowledge (48%), the attitude of the respondents who agreed in checkups (32%). Spearman rank correlation test results showed no correlation between knowledge of pregnant with high risk pregnancy incidence (rs = - 0.06 and p = 0.965), and there is a relationship attitude of pregnant in antenatal with the incidence of high-risk pregnancies (rs = 0.339 and p = 0.016). Further studies with a qualitative method of knowledge and attitude of pregnant on the incidence of high risk pregnancy that can be brought to more complete information and comprehensive.Keywords: knowledge, attitude, high risk pregnancy
FAKTOR PENYEBAB ARTEFAK PADA HASIL RADIOGRAF (SOFT COPY) COMPUTED RADIOGRADPHY DI RSUP. DR.SOERADJI TIRTONEGORO KLATEN
Authors: Sari Ayu Wita , Ly Fad 
Published: March 2019

Computed radiogradphy digunakan sebagai modalitas baru dalam pembuatan diagnosa dengan banyak memberikan keunggulan dibandingkan radiografi konvensional. Computed radiogradphy menghasilkan artefak yang berbeda dari radiografi konvensional. Artefak dihasilkan dari berbagai model perangkat computed radiogradphy seperti imaging plate, kaset, elektro optik sebuah sistem untuk mengembangkan citra, sedangkan komputer algoritma digunakan untuk memproses gambar laten dan perangkat output hard copy. Semua komponen ini dapat menjadi sumber artefak. Tujuan dari penelitian ini adalah untuk mengetahui faktor-faktor penyebab artefak dan faktor penyebab artefak terbesar pada hasil radiograf (soft copy) computed radiogradphy di instalasi Radiologi RSUP Dr. Soeradji Tirtonegoro Klaten. Metode penelitian yang digunakan yaitu studi kasus dengan pendekatan kualitatif. Data diperoleh dengan melakukan observasi, wawancara dan dokumentasi mengenai faktor penyebab artefak pada hasil radiograf softcopy computed radiogradphy di Instalasi Radiologi RSUP Dr. Soeradji Tirtonegoro Klaten. Hasil penelitian menjelaskan bahwa faktor penyebab artefak pada hasil radiograf softcopy computed radiogradphy disebabkan oleh dua faktor yaitu faktor imaging plate dan kesalahan penggunaan grid. Sedangkan artefak terbesar dikarenakan faktor kesalahan penggunaan grid yaitu sebesar 82%.Kata Kunci : artefak, radiograf softcopy, computed radiogradphy THE CAUSE OF ARTIFACTS IN THE COMPUTED RADIOGRAPHY (SOFTCOPY) RESULT IN RSUP DR. SOERADJI TIRTONEGORO KLATENComputed radiology is used as a new technology in diagnosing by giving some advantages than conventional radiography. Computed radiology produces the different artifacts than the conventional one. The artifacts are produced by some models of computed radiography such as imaging plate, cassette,electrical optic, is a system to improve the images, however computer algorithm is used in processing laten images, and hard copy. All of components are the source of artifact. The purpose of this research is to know the cause of artifacts and the biggest factor of artifact in the soft copy of computed radiology result in Radiology Instalation RSUP Dr. SoeradjiTirtonegoroKlaten. The methodology of the research is case study in qualitative approach. The data is produced by observation, interview, and documentation about the cause of artifacts in computed radiology soft copy result in Radiology Instalation of RSUP Dr. SoeradjiTirtonegoroKlaten. The result of the research is explaining that the cause of the artifacts in the computed radiology softcopy result is caused by two factors, they are imaging plate and the faults of the grid using. However the biggest artifact is caused by the fault of the grid using, it is 82 %.Key words: artifact, radiology softcopy, computed radiology
Yoğun bakım ünitesinde akut intoksikasyon vakalarının incelenmesi
Authors: YEŞİLER Fatma İrem , ŞENDUR Ümit Gökhan , İNAN DEMİROĞLU Gamze 
Published: March 2019

Amaç: Bu çalışmada, periferde yer alan
yeni kurulan erişkin yoğun bakım ünitesinde (YBÜ) bir yıl içerisinde takip
edilen zehirlenme vakalarının demografik ve etiyolojik özelliklerini, yoğun
bakım kalış sürelerini retrospektif olarak sunmayı amaçladık.

Gereç
ve Yöntem: Çalışmamızda 1
Ocak 2017- 31 Aralık 2017 tarihleri arasında YBÜ’ ye kabul edilen 44 akut zehirlenme
olgusunun yaş, cinsiyet dağılımları, zehirlenme nedenleri, komplikasyonları,
yoğun bakım- hastane kalış süreleri ve sağkalım durumları retrospektif olarak
değerlendirildi.

Bulgular: On beşi erkek, 44 erişkin hasta
retrospektif olarak değerlendirildi. Hastaların yaş ortalaması
28.07±10.2 idi. Hastaların %84’ nün suisid amaçlı ilaç ve/veya kimyasal madde
aldıkları, %13.6’ sının yanlışlıkla veya kaza sonucu, 1 hastanın ise aşırı
alıma bağlı maruziyetinin olduğu saptandı. Hastaların %59.1’ i medikal ilaç
intoksikasyonu, %11.4’ ü tarım ilacı, %9.1’i fare zehiri gibi nedenlerden
dolayı akut intoksikasyon tanısı ile YBÜ’ne kabul edildi. Üç hastada (%6.8)
karaciğer fonkiyon testlerinde artış ve nörolojik tutulum, 1 hastada ise koagülopati
saptandı. Vakaların YBÜ’ de ortalama yatış süresi 2.5±0.95 gündü. İntoksikayona
bağlı ölüm gözlenmedi.

Sonuç: Akut intoksikasyon vakaları
ciddi bir klinik tablo oluşturabileceği için YBÜ’ de takip edilmesi gereken
hasta grubudur. Bu hastalarda toksikasyona neden olabilecek ilaç ve maddeler en
kısa sürede saptanmalı, oluşabilecek yan etkilere karşı dikkatli olunmalı ve
hızlıca tedaviye başlanmalıdır.
Identifikasi Risiko dan Pencegahan Terhadap Nefropati Akibat Kontras
Authors: Wijaya Andre Tjie , Atmadja Budiawan 
Published: March 2019

The increase of application of iodinated contrast medium in diagnostic practice, combined with the increase of renal insufciency patients and elderly resulted in increasing incidency of contrast-induced nephropathy (CIN). The use of iodinated contrast medium need a careful assessment between risk and beneft, especially in patients with history of renal disease and elderly. Assessment of renal function is based on glomerular fltration rate, not serum creatinine. Avoidance of iodinated contrast medium is the frst step to prevent the development of CIN. Consideration of alternative imaging is important. But, if iodinated contrast medium is needed, volume expansion intravenous before and after administration is the next acknowledged prevention step.
The calcite-aragonite transition : mechanism and microstructures induced by the transformation stresses and strain
Authors: Gillet Philippe , Gérard Yves , Willaime Christian 
Published: March 2019

The calcite-aragonite transition has been experimentally investigated both under hydrostatic conditions and in the presence of deviatoric stresses. The calcite → aragonite experiments at high-pressure have been performed in a Griggs apparatus in the presence of deviatoric stresses whereas the aragonite → calcite experiments were conducted at room pressure (hydrostatic conditions) on a heating stage. For both kinds of experiments partially transformed samples were observed by transmission electron microscopy (T.E.M.). The same morphology of the interface between polymorphs and the existence of epitactic relationships among low-index crystallographic planes in both kinds of experiments suggest that whatever the experimental conditions and sense of reaction, the transition proceeds by the motion of highly-coherent interfaces. No evidence for a shear mechanism was found.
The growth of calcite in aragonite at room pressure leads to a high dislocation density (1014 m-2) in calcite and to mechanical twins in aragonite. Recovery textures like subgrains or recrystallized grains are observed in the calcite grains. The defects observed in both phases are explained by the transformation stresses due to the irregular interface between polymorphs and to the volume change at the transition. The implications for transformation plasticity and for the stability of phases are briefly discussed.