bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity of the Patient-Reported Outcome Measurement Information System (PROMIS) Sexual Interest and Satisfaction Measures in Men Following Radical Prostatectomy
Authors: Agochukwu Nnenaya Q. , Wittmann Daniela , Boileau Nicholas R. , Dunn Rodney L. , Montie James E. , Kim Tae , Miller David C. , Peabody James , Carlozzi Noelle E. ,   for the Michigan Urological Surgery Improvement Collaborative
Published: June 2019

PURPOSE Patient-reported outcomes after radical prostatectomy have focused on erectile function. To date, no studies have validated the Patient-Reported Outcome Measurement Information System (PROMIS) Sexual Interest and Satisfaction single item measures in patients with prostate cancer, nor have studies examined how these measures relate to erectile function. In addition, data are lacking with regard to the clinical responsiveness of these measures to treatment. We sought to validate and examine the clinical utility of these measures in men after radical prostatectomy. PATIENTS AND METHODS We identified men who underwent a robotic radical prostatectomy from May 2014 to January 2016 in the Michigan Urological Surgery Improvement Collaborative. A single item from the PROMIS Global Satisfaction With Sex Life subdomain and a single item from the PROMIS Interest in Sexual Activity subdomain were administered. Erectile function was also assessed. Differences between baseline and 24-month T-scores for both PROMIS interest and satisfaction were examined. Multilevel models were constructed to examine change over time. RESULTS A total of 1,604 patients were included in the analysis. Convergent and discriminant validity of the PROMIS measures was supported. The mean PROMIS interest T-score decreased significantly from baseline to 3 months ( P = .001) and significantly increased from 3 months to 24 months in this cohort, with 24-month scores exceeding baseline scores ( P < .001). The mean PROMIS satisfaction T-score declined from baseline to 3 months and increased from 3 months to 24 months ( P < .002). CONCLUSION PROMIS Global Satisfaction With Sex Life and Interest in Sexual Activity single-item measures are fundamental measures in prostate cancer survivorship. Patients are interested in sex despite functional losses and can salvage satisfaction, thereby giving insight into attainable patient-centered survivorship goals for sexual recovery after radical prostatectomy.
The performance of bovine serum albumin filtration by using polyethersulfone-Tetronic 304 blend Ultrafiltration Membrane
Authors: Razi Fachrul , Mulyati Sri , Arahman Nasrul 
Published: June 2019

Background: Membrane technology has been widely applied for protein purification. In applications for protein separation, a membrane with stable filtration performance is necessary. In this work, two types of hollow fiber membranes with different characteristic were used to study the filtration profile of bovine serum albumin. Methods: A single piece of hollow fiber module was used for ultrafiltration testing using UF0 and UFT304 membranes. Flux and rejection of BSA solution were collected based on a pressure-driven inside filtration model. Results: Ultrafiltration experiments showed that the flux of UFT304 membrane was higher than that of UF0 membrane in all applied pressure condition. Solute rejection was achieved up to 90% for ultrafiltration of BSA solution by using UF0 membrane obtained on the operating pressure of 0.5 atm. Conclusion: In general, UFT304 membranes has better ultrafiltration performance for BSA separation than UF0 membranes. The UFT304 membrane has a more stable flux for up to two hours of filtration.
Protocol for a phase I trial of a novel synthetic polymer nerve conduit 'Polynerve' in participants with sensory digital nerve injury (UMANC)
Authors: Murphy Ralph , Faroni Alessandro , Wong Jason , Reid Adam 
Published: June 2019

Background: Peripheral nerve injuries are common, with approximately 9,000 cases in the UK annually. Young working individuals are predominantly affected, leading to significant health and social implications. Functional recovery is often poor with impaired hand sensation, reduced motor function and pain and cold intolerance. Where a nerve gap exists, nerve grafting remains the gold-standard treatment but creates a second surgical site, sensory deficit at the donor site, possible neuroma formation and has limited availability. Current commercially available synthetic and resorbable nerve conduit alternatives are reported to be rigid and inflexible. This study will set out to examine the first-in-man use of a new nerve conduit device ‘Polynerve’ to repair small nerve gaps in digital sensory nerves of the hand. Polynerve is a degradable co-polymer of poly-ε-caprolactone and poly-l-lactic acid, which is shaped as a cylinder that has greater tensile strength, flexibility and less acidic degradation compared with current commercially available synthetic nerve conduits. In addition, it has a novel micro-grooved internal lumen that aids Schwann cell ingress and alignment to improve nerve regeneration. Methods: In total, 17 eligible participants will be recruited to undergo repair of a transected sensory nerve of the hand using the Polynerve device. All participants that receive the nerve conduit device will be followed for a period of 12 months post-surgery. The primary endpoint is safety of the device and the secondary endpoint is degree of sensory nerve regeneration through the conduit assessed using standard sensory testing (2-PD, WEST monofilament testing and locognosia). Discussion: The ‘UMANC’ trial is a single-centre UK-based, prospective, unblinded, phase I clinical trial of a novel nerve conduit device. We aim to demonstrate the safety of Polynerve as a synthetic, biodegradable nerve conduit and improve the treatment options available to patients with significant nerve injuries. Registration: Clinicaltrials.gov: NCT02970864; EudraCT: 2016-001667-37.
aDolescents gEnder surVey, rEsponsible coupLes evaluatiOn, and capacity building Project in India (DEVELOP): a study protocol
Authors: Ahankari Anand , Hayter Mark , Whitfield Clare , Ali Parveen , Giridhari Sneha , Tambe Shruti , Kabra Pratyush , Rayamane Kranti , Ovseiko Pavel 
Published: June 2019

Gender-based violence against women is a serious concern in India. This affects the health and wellbeing of victims and their dependents. Published evidence has documented a variety of reasons for such violence in Indian societies, paving a pathway to design, implement, and evaluate intervention models to address this issue. DEVELOP is a research study designed by UK and Indian research teams to plan future projects to address gender-based discrimination and violence against women and girls in India. This study protocol provides detailed information on the objectives, research methods, data collection, storage, analysis, and dissemination plans of the DEVELOP. The first component is a survey of adolescent boys and girls from rural areas of Maharashtra state of India to understand their gender equality related knowledge and beliefs. The insight gathered will be used to design interventions targeted at adolescent populations through future research and development programmes. Secondly, an evaluation of the ‘Responsible Couples’ project will be conducted to assess its success and challenges, and to design suitable programme activities and models. The ‘Responsible Couples’ project is implemented in 40 villages of Maharashtra state to improve relationships in married couples, prevent violence against women, intervene during violence, and to provide support services for women and their family members. Research findings will be disseminated though public engagement events in India, international conferences, and peer reviewed publications. This will impact on the policy and work models of Indian partners to plan future project investments. Research findings will be also useful for local government authorities and non-government agencies striving to advance gender equality.
Mapping Soil Properties and Delineating Management Zones Based on Electrical Conductivity in a Hedgerow Olive Grove
Authors: Millán Sandra , Moral Francisco Jesús , Prieto Maria Henar , Pérez-Rodriguez Juan Manuel , Campillo Carlos 
Published: June 2019

Abstract. Identifying spatial patterns of soil and plant properties can be an efficient method for site-specific management in areas with homogeneous characteristics (i.e., management zones, MZs). In this study, the use of soil apparent electrical conductivity (ECa) is proposed as the main information source for evaluating the spatial variability of soil and plant properties when using this variability to determine potential MZs. This study was conducted in a commercial hedgerow olive grove. Spatial distribution maps of the main soil properties and normalized difference vegetation index (NDVI) were generated by regression-kriging in which ECa was used as a secondary variable. According to the results obtained by the validation process, all maps were accurate. Soil and plant properties and ECa were subjected to principal component analysis (PCA). Two MZs were determined using a fuzzy cluster classification. The MZ map was validated using data related to soil samples, yield, and NDVI. Establishing different MZs was useful for adapting the irrigation strategies to the soil conditions of the plot, which resulted in increased productivity of the hedgerow olive grove. Keywords: Fuzzy c-means, Principal components analysis, Regression-kriging, Spatial prediction.
An Approach for Indirect Determination of Leaf Area Index
Authors: Logsdon Sally D. , Cambardella Cindy A. 
Published: June 2019

Abstract. Leaf area index (LAI) is important in crop models, but determination of LAI can be challenging for crops and mixtures of crops. The purpose of this study was to determine LAI indirectly from ground cover (determined from photographic images) and canopy height using defined relationships based on crop coefficients. Images of plant canopies were obtained to estimate the green cover fraction. An equation was derived to determine LAI from ground cover and plant height, and the technique was tested on different crops. For three of the measurement dates, the data were compared to LAI measurements obtained with a LAI-2200 plant canopy analyzer. The trend was the same for the two LAI procedures, but there was some scatter. The photographic technique was adequate for LAI determination. Keywords: Ground cover, Plant canopy cover, Plant height.
Microbial Transport as Affected by Residue Cover and Manure Application Rate
Authors: Durso Lisa A. , Gilley John E. , Marx David B. , Thayer Chance A. , Woodbury Bryan L. 
Published: June 2019

Abstract. Manure is applied to cropland areas with varying surface cover to meet single- or multiple-year crop nutrient requirements. The objectives of this field study were to (1) examine microbial transport following land application of manure to sites with and without wheat residue, (2) compare microbial loads following land application to meet the 0, 1, 2, 4, and 8-year P-based requirements for corn, and (3) evaluate the effects of rainfall simulation run on microbial transport. Manure was added and incorporated by disking plots that were 0.75 m wide by 2.0 m long. Three 30 min simulated rainfall events, separated by 24 h intervals, were then applied at an intensity of 70 mm h-1. Plots containing wheat residue had a total coliform load of 12.6 log CFU ha-1, which was significantly greater than the 12.4 log CFU ha-1 measured on the plots without wheat residue. The plots with and without wheat residue had transport rates of and enterococci that were not significantly different. The plots on which manure was added at rates varying from 5.4 to 42.8 Mg ha-1 had counts of total coliforms and enterococci that were not significantly different. Rainfall simulation run did not significantly affect measurements of phages, total coliforms, or enterococci. Transport of selected microbes was found to be significantly affected by residue cover, manure application rate, and rainfall simulation run. Keywords: Bacteria, Cattle manure, E. coli, Feedlots, Land application, Manure management, Manure runoff, Microbial, Microorganisms, Runoff.
The Characteristics of Products from Pyrolysis of Seaweed in Molten Carbonates
Authors: Wei Yi , Tang Jitong , Ji Jianbing 
Published: June 2019

Abstract. The characteristics of the seaweed (SH) were investigated as a feedstock for slow pyrolysis and molten carbonate (MC) pyrolysis within the temperature range of 400°C to 600°C. SH differs from terrestrial biomass in its constitutional compounds and high N content. According to thermogravimetric analysis, decomposition of proteins and cellulose played the most important role in thermal degradation of SH. The yields and distributions of syngas and bio-oil from MC pyrolysis varied with temperature and were greatly different from those of slow pyrolysis. MC pyrolysis increased gas generation by 10.46 wt% while reducing solids yield from 38.10 wt% to 31.99 wt% at 600°C. Of the gaseous products, H2 was dominant, and CO2 was also prominent. Conversion of tar and acid in the bio-oil was significantly improved in the molten salts medium, while nitrogen content was significantly reduced in the bio-oil. MC pyrolysis minimized the obstacles to heat transfer during pyrolysis by heating the feedstock from both inside and outside. Keywords: Intensification, Molten carbonates, Pyrolysis, Sargassum horneri.
Validation of the size morphology site access score in endoscopic mucosal resection of large polyps in a district general hospital
Authors: Currie AC , Merriman H , Nadia shah Gilani S , Mackenzie P , McFall MR , Baig MK 
Published: June 2019

Background Polyp assessment is multimodal and is vital prior to endoscopic mucosal resection. The size, morphology, site and access (SMSA) score has been validated in specialist endoscopic institutions. this study investigated the ability of this score to predict incomplete endoscopic resection of large colorectal polyps in a district general hospital Methods Consecutive patients undergoing endoscopic mucosal resection of large (≥ 20 mm) colorectal polyps at Worthing Hospital. Clinical, endoscopic and histological data were taken from prospective databases. The primary outcome of the study was to investigate the correlation of the SMSA score with incomplete endoscopic resection. Results Between February 2015 and August 2018, 114 patients underwent colorectal endoscopic mucosal resection. Of these, 67 (59%) were male. The median (interquartile range) age of the study population was 72 years (65–78 years). Some 17 lesions (15%) were pedunculated, 76 (67%) were sessile and 21 were (18%) flat; 84 polyps (77%) were located in the left colon/rectum, with the remainder in the right colon; 51 lesions (45%) were 20–30 mm, 27 (24%) were 30–40 mm and 36 (31%) were greater than 40 mm in diameter. When reclassified into the SMSA score, 9 of the polyps (8%) were level 2, 64 (56%) were level 3 and 41 (36%) were level 4. Incomplete resection was clinically diagnosed in 9/114 (8%). The SMSA score was positively correlated with incomplete endoscopic resection, but not with additional procedure usage, complications or advanced histology. Conclusions Many patients with large polyps can be managed outside of specialist units. This study has validated that the SMSA score was associated with incomplete endoscopic mucosal resection for large polyps in a district general hospital setting.
RACIONALIDADE INSTRUMENTAL E FORMAÇÃO HUMANA: UMA ANÁLISE A PARTIR DA TEORIA DO CAPITAL HUMANO
Authors: Da Silva Gilmar Pereira , Da Silva Élido Santiago 
Published: June 2019

O presente artigo tem como objetivo caracterizar os currículos dos cursos do ensino médio integrado à educação profissional a partir da racionalidade intrumental manifesta na proposta de formação humana. Tal proposição cumpriu-se por meio da análise dos projetos pedagógicos dos cursos de ensino médio integrado à educação profissional e do projeto pedagógico do Instituto Federal de Ciência e Tecnologia do Piauí – Campus Parnaíba. Destaca-se como referencial teórico os conceitos de Racionalidade Instrumental (SERVA, 1997; GUERREIRO RAMOS, 1981); Teoria do Capital Humano (SCHULTZ, 1973); Economia da Educação (CARNOY, 2006). Com a análise, chegou-se à delimitação de três categorias: “o mercado e seus serviços”; “a política pública de desenvolvimento”; e “o empreendedorismo e a formação humana instrumental”. Como achado da pesquisa, destaca-se que a escola é um intenso movimento de assimilação e resistência frente ao projeto capitalista de formação humana e, no Instituto pesquisado, a racionalidade instrumental se manifesta nos documentos oficiais, tencionando a formação humana para um padrão de reprodução dos mecanismos de adaptação do processo educativo que de uma forma tende a uma formação parcializada pelo próprio projeto do capital.
Diagnosis of the phenomenon of cognitive-motor dissociation in patients with chronic consciousness disorders
Authors: Belkin V. A. , Pozdnyakov D. G. , Belkin A. A. 
Published: June 2019

Locked-in syndrome in basilar artery thrombosis is a classic example of dissociation between preserved consciousness and complete deefferentation as total myoplegia with preserved vertical eye movement. Something similar is observed in post-comatose patients, described under the name “functional locked-in syndrome”, and is also a clinical reflection of the phenomenon of cognitive-motor dissociation (CMD). Diagnosis of this condition in a patient with chronic consciousness disorders indicates that there may be a cognitive imprint, which gives a chance for the maximum realization of the rehabilitation potential of latent consciousness as an exit to the clinical level of small consciousness or creation of a brain-interface. In any case, this patient should be given an extended rehabilitation program.Objective: to search for the optimal set of clinical and instrumental diagnostic methods, allowing the identification of CMD in patients with chronic consciousness disorder.Patients and methods. The 2016–2018 prospective single-center study enrolled patients with unresponsive wakefulness syndrome (UWS) who had received a treatment cycle at the Clinical Brain Institute (Yekaterinburg). The study included 39 patients (22 men, 17 women) aged 19 to 71 years who had sustained various cerebral injuries (traumatic, hypoxic, and acute vascular disease-associated) in different periods (from 32 to 2431 days) before being included in the study. All the patients underwent 5-fold clinical assessments according to the Coma Recovery ScaleRevised (CRS-R) and navigated transcranial magnetic stimulation (nTMS) in order to determine the time course of changes in the activity of the cortical motor centers at the time of presentation of verbal paradigms. Registration of the changes was assessed as the presence of a cognitive imprint and served as a criterion for diagnosing CMD as a positive predictor for the outcome of UWS. The outcome of the state was analyzed using the Glasgow Outcome Scale (GOS) at 180 days.Results and discussion. Positive changes (GOS >3) were noted in 10 (66%) patients with established CMD; the patients who had not diagnosed as having the cognitive potential showed a further increase in the level of cognition in 3 (12.5%) cases. Whether the identified sign could be used in the comprehensive prediction of chronic consciousness disorder was discussed.Conclusion. The use of TMS in diagnosing the phenomenon of CMD optimizes the routing of patients, for whom intensive rehabilitation can contribute to more favorable long-term outcomes.
Differential Changes in the Lateralized Activity of Identified Projection Neurons of Motor Cortex in Hemiparkinsonian Rats
Authors: Rios Alain , Soma Shogo , Yoshida Junichi , Nonomura Satoshi , Kawabata Masanori , Sakai Yutaka , Isomura Yoshikazu 
Published: June 2019

AbstractIn the parkinsonian state, the motor cortex and basal ganglia (BG) undergo dynamic remodeling of movement representation. One such change is the loss of the normal contralateral lateralized activity pattern. The increase in the number of movement-related neurons responding to ipsilateral or bilateral limb movements may cause motor problems, including impaired balance, reduced bimanual coordination, and abnormal mirror movements. However, it remains unknown how individual types of motor cortical neurons organize this reconstruction. To explore the effect of dopamine depletion on lateralized activity in the parkinsonian state, we used a partial hemiparkinsonian model [6-hydroxydopamine (6-OHDA) lesion] in Long–Evans rats performing unilateral movements in a right–left pedal task, while recording from primary (M1) and secondary motor cortex (M2). The lesion decreased contralateral preferred activity in both M1 and M2. In addition, this change differed among identified intratelencephalic (IT) and pyramidal tract (PT) cortical projection neurons, depending on the cortical area. We detected a decrease in lateralized activity only in PT neurons in M1, whereas in M2, this change was observed in IT neurons, with no change in the PT population. Our results suggest a differential effect of dopamine depletion in the lateralized activity of the motor cortex, and suggest possible compensatory changes in the contralateral hemisphere.
Políticas sexuadas na Turquia: um novelo emaranhado
Authors: Kandiyoti Deniz 
Published: June 2019

A Turquia é frequentemente apontada como o único país predominantemente muçulmano com constituição laica e com um Código Civil que não obedece à xaria, sendo que o movimento de mulheres obteve vitórias importantes em matéria de reformas jurídicas no início dos anos de 2000. Observa-se, entretanto, um crescente abismo entre direitos formais e direitos reais após a esmagadora vitória do AKP, em 2007. Por conta das divisões que atravessam as fileiras feministas – particularmente acerca da questão do véu – o artigo se pergunta sobre a validade de tais conquistas.
“As mulheres” nos documentos do Papa João Paulo II: um modelo assimétrico ainda não superado
Authors: Duarte Doneda Perla Cabral 
Published: June 2019

O presente artigo tem como objetivo apresentar a análise bibliográfica dos documentos pontifícios do Papa João Paulo II que tratam do modelo de mulher, na visão da Igreja Católica Apostólica Romana. Na perspectiva de gênero, é possível observar a representação social das mulheres desenvolvida pela hierárquica católica, cujo corpo eclesiástico é totalmente masculino, logo, o patriarcado se faz presente na manutenção do poder e na elaboração normativa. Para tanto, os documentos pontifícios analisados foram: a Exortação Apostólica Familiares Consortio, de 1981; a Carta Encíclica Redemptoris Mater, de 1987; a Carta Apostólica Mulieris Dignitatem, datada de 1988; a Carta Apostólica Ordinatio Sacerdotalis, de 1994; a Carta Às Famílias, do ano de 1994; a Carta Às Mulheres, de 1995 e, por último, a Carta aos bispos da Igreja Católica sobre a Colaboração do homem e da mulher na Igreja e no mundo, do ano de 2004. Conforme estes documentos, há um único modelo de mulher a ser seguido por todas as mulheres, uma vez que, Maria é a representação única do feminino, segundo João Paulo II. Sendo assim, vocação e dignidade mariana deve ser imitada por todas as mulheres. De acordo com o processo de análise destes documentos, palavras-chave foram se aglutinando, o que originou um ranking delas, sugerindo normas e condutas cristãs às mulheres, revelando os processos de linguagem e de materiais simbólicos, utilizados nas práticas religiosas. Ademais, na visão da Igreja Católica, as mulheres devem seguir esse modelo para assim manter a feminilidade, a ordem familiar e, principalmente, a ordem religiosa e social.