bluuebunny/crossref_metadata_2025_split huggingface dataset:
The polymorphisms of miRNA‐binding site in MLH3 and ERCC1 were linked to the risk of colorectal cancer in a case–control study
Authors: Zhang Qianye , Zheng Xiao , Li Xiaoxia , Sun Deyu , Xue Ping , Zhang Guopei , Xiao Mingyang , Cai Yuan , Jin Cuihong , Yang Jinghua , Wu Shengwen , Lu Xiaobo 
Published: March 2018

AbstractColorectal cancer (CRC), as a malignant tumor of lower digestive tract, has been found to have an increasing morbidity and mortality in China. It was particularly important to find some earlier biomarkers to predict the risk and prognosis. In this study, several polymorphisms on 3′UTR of three DNA repair genes including MLH3 rs10862, ERCC1 rs3212986, ERCC1 rs735482, ERCC1 rs2336219, and OGG1 rs1052133 were chosen by bioinformatics exploration, and then, a case–control study of 200 CRC cases and controls was performed. Furthermore, a dual‐luciferase assay was also carried out to certify whether the candidate miRNA can regulate its target gene and the selected SNPs have a valid effect on the target miRNA. Finally, both of ERCC1 rs3212986 and MLH3 rs108621 were shown to be associated with the risk of CRC. Comparing with rs3212986 CC genotype, AA was at a higher risk (OR = 3.079, 95% CI: 1.192–7.952). For MLH3 rs108621, comparing with TT genotype, CC and TC were at a higher risk of CRC in male (OR = 5.171, 95% CI: 1.009–26.494; OR = 1.904, 95% CI: 1.049–3.455). Interestingly, an analysis combining both ERCC1 rs3212986 and MLH3 rs108621 also showed an increased risk of CRC. In addition, a dual‐luciferase assay showed that miR‐193a‐3p could regulate MLH3, and the polymorphism rs108621 could alter the miR‐193a‐3p binding to MLH3. Therefore, MLH3 rs108621 may be associated with the risk of CRC due to the effect of miR‐193a‐3p on MLH3, which reminded the possibility as potential susceptibility biomarkers to predict the risk of CRC.
Video evidence of improved hand function following repetitive transcranial magnetic stimulation combined with physical therapy in stroke: a case report
Authors: Carey James R. , Chen Mo , Streib Christopher D. 
Published: March 2018

Key Clinical MessageIn a 46‐year‐old female 6 months poststroke who presented with minimal paretic hand function, repetitive transcranial magnetic stimulation (rTMS), and exercises considerably improved her function beyond that accomplished with conventional rehabilitation. However, intermittent rTMS (2 sessions/week) was required to sustain the benefits. Research is required to determine the critical frequency of intermittent rTMS needed to sustain functional gains long term.
What can go wrong in hyperemesis gravidarum: Wernicke–Korsakoff syndrome in Bulawayo, Zimbabwe
Authors: Nhari Fiona T. , Dzvanga Narcisious B. T. 
Published: March 2018

Key Clinical MessageWe report two cases of Wernicke–Korsakoff syndrome (WKS) secondary to hyperemesis gravidarum. Oral thiamine was administered (intravenous unavailable locally). However, both the patient's condition improved in the first 48 h and progressively over a month. Initially, WKS is missed due to rare feature of full classical triad of symptoms, especially in nonalcoholics.
Ablation of parahisian premature ventricular extrasystoles by subtricuspid retrograde approach using inverted catheter technique: back to the anatomy
Authors: Candemir Basar , Duzen Veysel , Coskun Firat , Vurgun Veysel Kutay , Goksuluk Huseyin , Ozyuncu Nil , Kurklu Seda Tan , Altin Ali Timucin , Akyurek Omer , Erol Cetin 
Published: March 2018

Key Clinical MessageThis report illustrates a feasible and anatomical solution aiming to improve the success and decrease the possible hazards such as atrioventricular block during ablation of parahisian PVCs. We tried to illustrate the specific anatomy pertaining parahisian region and to explain a retrograde subvalvular catheter technique to overcome these procedural obstacles.
Life threatening nontraumatic tension gastrothorax
Authors: El Hajj Ihab I. , McCabe Marshall , Ceppa DuyKhanh P. , Fridell Jonathan A. , Sherman Stuart 
Published: March 2018

Key Clinical MessageTension gastrothorax is a rare condition, which poses a diagnostic dilemma and can be mistaken for a tension pneumothorax. Awareness of the risk factors, clinical presentation, and radiology findings of tension gastrothorax can help with the prompt identification and successful management of this life‐threatening condition.
Evoked potential studies for predicting functional recovery in a case of acute necrotizing encephalopathy
Authors: Onozawa Yuya , Iwasaki Toshiyuki , Iizuka Takahiro , Nonoda Yutaka , Toki Taira , Obata Susumu , Munekata Shinichi , Kanoh Yuhsaku 
Published: March 2018

Key Clinical MessageNormal‐appearing evoked potentials during the acute stage of the disease despite persistent coma may predict subsequent functional recovery of the brain in a pediatric case of acute necrotizing encephalopathy, indicating that evoked potential studies are useful for predicting functional outcome of the brain.
Two episodes of Taravana syndrome in a breath‐hold diver with hyperhomocysteinemia
Authors: Accurso Giuseppe , Cortegiani Andrea , Caruso Sabrina , Danile Oriana , Garbo Domenico , iozzo Pasquale , Vitale Filippo , Raineri Santi Maurizio , Gregoretti Cesare , Giarratano Antonino 
Published: March 2018

Key Clinical MessageTaravana syndrome is a rare dysbaric disease characterized by neurologic signs and symptoms. Differently from others decompression illness, it has unspecified pathophysiology and unclear predisposing factors. Our cases suggest that thrombophilic state due to hyperhomocysteinemia could increase the risk to develop Taravana syndrome.
Selective Catalytic Reduction of NOxwith Ammonia over Copper Ion Exchanged SAPO‐47 Zeolites in a Wide Temperature Range
Authors: Zhang Yani , Peng Yue , Wang Chizhong , Li Kezhi , Liu Shuai , Li Xiansheng , Chen Jianjun , Li Junhua 
Published: March 2018

AbstractCopper‐exchanged H‐SAPO‐47 zeolites were synthesized by an aqueous solution ion exchange method and applied in the selective catalytic reduction of NO with NH3(SCR). The microporous chabazite (CHA) structure of the catalysts was characterized and confirmed using synchrotron X‐ray diffraction and nitrogen adsorption–desorption experiments. The synthesized Cux‐SAPO‐47 catalysts exhibited excellent SCR activity and nearly 100 % N2selectivity in a wide temperature range. The Cu0.1‐SAPO‐47 sample exhibited higher activity than the other samples below 250 °C. The weak Lewis acid sites originating from the introduction of Cu2+were more active than the Brønsted acid sites of the zeolites framework at low temperature. Two types of isolated Cu2+species with different coordination surroundings were found, namely, Cu2+cations bonded with the six‐membered rings and those bonded in the CHA cages. The former species exhibited good stability and activity at high temperature, whereas the latter ones were more active at low temperature. The Cu0.1‐SAPO‐47 catalyst provided a considerable amount of isolated Cu2+bonded in the CHA cages. These results indicated that active Lewis acid sites and isolated Cu2+species are responsible for their excellent SCR activity.
Effect of Ba Content on the Activity of La1‐xBaxMnO3 Towards the Oxygen Reduction Reaction
Authors: Gobaille‐Shaw Gael. P. A. , Celorrio Veronica , Calvillo Laura , Morris Louis J. , Granozzi Gaetano , Fermín David. J. 
Published: March 2018

AbstractThe electrocatalytic activity of La1‐xBaxMnO3 nanoparticles towards the oxygen reduction reaction (ORR) is investigated as a function of the A‐site composition. Phase‐pure oxide nanoparticles with a diameter in the range of 40 to 70 nm were prepared by using an ionic liquid route and deposited onto mesoporous carbon films. The structure and surface composition of the nanoparticles are probed by XRD, TEM, EDX, and XPS. Electrochemical studies carried out under alkaline conditions show a strong correlation between the activity of La1‐xBaxMnO3 and the effective number of reducible Mn sites at the catalysts layer. Our analysis demonstrates that, beyond controlling particle size and surface elemental segregation, understanding and controlling Mn coordination at the first atomic layer is crucial for increasing the performance of these materials.
Sarcomeric and nonmuscle α‐actinin isoforms exhibit differential dynamics at skeletal muscle Z‐lines
Authors: Hsu Cynthia P. , Moghadaszadeh Behzad , Hartwig John H. , Beggs Alan H. 
Published: March 2018

AbstractThe α‐actinin proteins are a highly conserved family of actin crosslinkers that mediate interactions between several cytoskeletal and sarcomeric proteins. Nonsarcomeric α‐actinin‐1 and α‐actinin‐4 crosslink actin filaments in the cytoskeleton, while sarcomeric α‐actinin‐2 and α‐actinin‐3 serve a crucial role in anchoring actin filaments to the muscle Z‐line. To assess the difference in turnover dynamics and structure/function properties between the α‐actinin isoforms at the sarcomeric Z‐line, we used Fluorescence Recovery After Photobleaching (FRAP) in primary myofiber cultures. We found that the recovery kinetics of these proteins followed three distinct patterns: α‐actinin‐2/α‐actinin‐3 had the slowest turn over, α‐actinin‐1 recovered to an intermediate degree, and α‐actinin‐4 had the fastest recovery. Interestingly, the isoforms’ patterns of recovery were reversed at adhesion plaques in fibroblasts. This disparity suggests that the different α‐actinin isoforms have unique association kinetics in myofibers and that nonmuscle isoform interactions are more dynamic at the sarcomeric Z‐line. Protein domain‐specific investigations using α‐actinin‐2/4 chimeric proteins showed that differential dynamics between sarcomeric and nonmuscle isoforms are regulated by cooperative interactions between the N‐terminal actin‐binding domain, the spectrin‐like linker region and the C‐terminal calmodulin‐like EF hand domain. Together, these findings demonstrate that α‐actinin isoforms are unique in binding dynamics at the Z‐line and suggest differentially evolved interactive and Z‐line association capabilities of each functional domain.
Selective Semihydrogenation of Phenylacetylene to Styrene Catalyzed by Alloyed Palladium/Gold Catalysts Anchored on Cerium Oxide
Authors: Zhang Sai , Xia Zhaoming , Chen Xiao , Gao Wei , Qu Yongquan 
Published: March 2018

AbstractChemoselective semihydrogenation of alkynes to alkenes is a significant organic transformation and long challenge for heterogeneous catalysts. Herein, the PdAu alloyed nanoparticles were successfully deposited on the surface of cerium(IV) oxide nanorods (NR‐CeO2) through an electroless chemical deposition process. Alloyed catalysts had an enhanced catalytic activity for hydrogenation of phenylacetylene and improved selectivity towards styrene, compared with the Pd/NR‐CeO2 and Au/NR‐CeO2 catalysts. The enhanced catalytic activity can be attributed to the alloying effects. Furthermore, the weak adsorption of styrene obtained from the modulated surface characteristics also benefits the improved chemoselectivity.
A Simple One‐Pot Strategy for Synthesizing Ultrafine SnS2 Nanoparticle/Graphene Composites as Anodes for Lithium/Sodium‐Ion Batteries
Authors: Li Xin , Sun Xiaohong , Gao Zhiwen , Hu Xudong , Ling Rui , Cai Shu , Zheng Chunming , Hu Wenbin 
Published: March 2018

AbstractSnS2/graphene composites have attracted extensive attention in energy storage owing to their excellent electrochemical performance. However, most of the previous methods to synthesize SnS2/graphene composites require long times, high temperatures, or high pressures, which are obstacles for practical low‐cost production. A simple one‐pot strategy to prepare SnS2/graphene composites has been developed, which is not time‐consuming (1 h) and requires moderate temperature (75 °C) in atmosphere. Through this method, ultrafine SnS2 nanoparticles anchored on graphene nanosheets are prepared and exhibit excellent electrochemical performance for both lithium and sodium storage. Specifically, as anodes for lithium‐ion batteries, the SnS2/graphene electrode delivers a high capacity of 1480 mAh g−1 after 50 cycles at 0.2 A g−1. Even at 10 A g−1, the SnS2/graphene electrode can achieve a capacity of 666 mAh g−1. A constructed full lithium‐ion cell exhibits a capacity of 957 mAh g−1 after 50 cycles at 1 A g−1. This simple one‐pot strategy may pave the way for large‐scale production and practical application of SnS2/graphene composites in energy storage.
Vegetation influences on infiltration in Hawaiian soils
Authors: Perkins Kim S. , Stock Jonathan D. , Nimmo John R. 
Published: March 2018

AbstractChanges in vegetation communities caused by removing trees, introducing grazing ungulates, and replacing native plants with invasive species have substantially altered soil infiltration processes and rates in Hawaii. These changes directly impact run‐off, erosion, plant‐available water, and aquifer recharge. We hypothesize that broad vegetation communities can be characterized by distributions of field‐saturated hydraulic conductivity (Kfs). We used 290 measurements of Kfs calculated from infiltration tests from 5 of the Hawaiian Islands to show this effect. We classified the data using 3 broad ecosystem categories: grasses, trees and shrubs, and bare soil. The soils of each site have coevolved with past and present ecological communities without significant mechanical disturbance by agriculture or urban development. Geometric mean values Kfs are 203 mm/hr for soils hosting trees and shrubs, 50 mm/hr for grasses, and 13 mm/hr for bare soil. Differences are statistically significant at the 95% confidence level. These examples show that it is feasible to make maps of relative Kfs based on field and ecosystem data. These ecosystem trends can be used to estimate ongoing changes to run‐off and recharge from climate and land use change. Greater Kfs for ecosystems with primarily trees and shrubs suggests that management decisions concerning reforestation or other changes of vegetation can have substantial hydrologic impacts.
Mainstreaming across political sectors: Assessing biodiversity policy integration in Peru
Authors: Zinngrebe Yves M. 
Published: March 2018

AbstractMainstreaming biodiversity across political sectors and levels is a central challenge to conserving global biodiversity. This article introduces biodiversity policy integration (BPI) as an analytical approach for assessing the ecological performance of nonenvironmental sectors using the following criteria: inclusion, operationalization, coherence, capacity and weighting. To date, we know little about the barriers and enabling factors for integrating biodiversity into sector policies in resource intensive economies of the Global South. BPI in Peruvian political sectors of Agriculture and Irrigation, Economy and Finance, Energy and Mining, Production and Fishery, and Communication and Transport were analyzed based on sector strategies, related legal and strategic documents as well as qualitative expert interviews. While sectors commit to biodiversity conservation in general terms, a weak operationalization of biodiversity targets and low institutional capacity results in ineffective policy. Specific targets and indicators are not yet incorporated into sector strategies, national development planning, the evaluation of impact assessments or budget allocation. Biodiversity policies remain disconnected from the sectors' policy practices, which undermines the potential of reducing harmful incentives (Aichi target 3) and maintaining production within sustainable limits (Aichi target 4). Based on the results I identify the framing of sector‐specific targets, favorable actor constellations and adaptive institutional learning arrangements as key elements for improving BPI. Facilitating agents, such as the environmental Ministry or intersectoral commissions, play a central role in generating ownership of biodiversity objectives in sector policy‐making and supporting institutional learning processes.
Effects of Chinese pickled and dried mustard on nutritional quality, sensory quality, and shelf life of steamed pork belly
Authors: Shen Qing , Wang Mengting , Tian Jinhu , Hu Lyulin , Ren Sijie , Chen Jianchu , Ye Xingqian , Liu Donghong 
Published: March 2018

AbstractSteamed pork with pickled and dried mustard (PDM) is a famous Chinese dish. Here, we examined the effects of PDM on nutritional quality, sensory quality, and shelf life of steamed pork belly. Proximate composition, lipid oxidation, fatty acid profiles, protein hydrolysis and oxidation, sensory evaluation, and induction period (IP) of steamed pork belly were determined after addition of different levels (0–100%, WPDM/Wpork belly) of PDM. The results demonstrated that PDM could significantly (p < .05) enhance the loss of moisture and fat, increase the ratio of unsaturated to saturated fatty acids, and decrease lipid and protein oxidation in steamed pork belly. Additionally, IP values and steamed pork belly preservation times increased as the amount of added PDM increased. Best sensory quality was achieved when moderate levels of PDM (40%) were added to steamed pork belly. These findings provide insights into the beneficial effects of PDM on steamed pork belly.
Appropriate parboiling steaming time at atmospheric pressure and variety to produce rice with weak digestive properties
Authors: Zohoun Elvire V. , Ndindeng Sali A. , Soumanou Mohamed M. , Tang Erasmus N. , Bigoga Jude , Manful John , Sanyang Sidi , Akissoe Noel H. , Futakuchi Koichi 
Published: March 2018

AbstractConsumers with diabetes mellitus have shown interest in products with low postprandial glucose. To produce rice for this group of consumers, the effect of parboiling steaming time (0, 5, 15, 25, 35, and 45 min) and variety (NERICA1, NERICA7, WITA4, and IR841) on resistant, damaged starch fractions and glycemic response in rats was investigated. Resistant and damaged starch fractions were influenced by variety and steaming time but this was not the case for glycemic index. Nonparboiled NERICA7 and NERICA7 steamed for 25 min recorded the highest (10.07%) and lowest (2.49%) resistant starch fraction, respectively. Resistant starch correlated negatively with protein and sodium and positively with lipids. Damaged starch was high for WITA4 steamed for 45 min (26.80%) and low for nonparboiled NERICA1 (6.59%). Damaged starch correlated positively with lipid content and negatively with ash and total starch content. NERICA7 steamed for 35 min recorded the lowest postprandial glucose level 30 min after feeding (0.16 g/L), while WITA4 steamed for 15, 25, and 35 min and nonparboiled NERICA7 recorded higher levels (0.76, 0.91, 0.84, and 0.76 g/L, respectively). NERICA7 steamed for 35 min recorded both low glycemic and weak digestive properties because the glycemic index was lowest 120 min and increased steadily up to 180 min after feeding. We conclude that the digestive properties of rice depend both on the intrinsic properties of the variety and the parboiling steaming time.
Environmentally relevant chemical mixtures of concern in waters of United States tributaries to the Great Lakes
Authors: Elliott Sarah M , Brigham Mark E , Kiesling Richard L , Schoenfuss Heiko L , Jorgenson Zachary G 
Published: March 2018

Abstract

The North American Great Lakes are a vital natural resource that provide fish and wildlife habitat, as well as drinking water and waste assimilation services for millions of people. Tributaries to the Great Lakes receive chemical inputs from various point and nonpoint sources, and thus are expected to have complex mixtures of chemicals. However, our understanding of the co-occurrence of specific chemicals in complex mixtures is limited. To better understand the occurrence of specific chemical mixtures in the US Great Lakes Basin, surface water from 24 US tributaries to the Laurentian Great Lakes was collected and analyzed for diverse suites of organic chemicals, primarily focused on chemicals of concern (e.g., pharmaceuticals, personal care products, fragrances). A total of 181 samples and 21 chemical classes were assessed for mixture compositions. Basin wide, 1664 mixtures occurred in at least 25% of sites. The most complex mixtures identified comprised 9 chemical classes and occurred in 58% of sampled tributaries. Pharmaceuticals typically occurred in complex mixtures, reflecting pharmaceutical-use patterns and wastewater facility outfall influences. Fewer mixtures were identified at lake or lake-influenced sites than at riverine sites. As mixture complexity increased, the probability of a specific mixture occurring more often than by chance greatly increased, highlighting the importance of understanding source contributions to the environment. This empirically based analysis of mixture composition and occurrence may be used to focus future sampling efforts or mixture toxicity assessments. Integr Environ Assess Manag 2018;14:509–518. © 2018 SETAC

Key Points
An empirically based analysis was used to identify commonly occurring chemical mixtures of concern in US tributaries to the Great Lakes. Chemical mixtures of concern were ubiquitous across US tributaries to the Great Lakes, representing complex exposure scenarios for fish and wildlife. Most chemical mixtures of concern occurred more often than by chance, which highlights the need to understand source contributions to the environment. This approach can be used to inform laboratory exposure experiments or resource management efforts focused on reducing total risk of biota to chemicals of concern.
Oxidative stress in organophosphate poisoning: role of standard antidotal therapy
Authors: Vanova Nela , Pejchal Jaroslav , Herman David , Dlabkova Alzbeta , Jun Daniel 
Published: March 2018

AbstractDespite the main mechanism of organophosphate (OP) toxicity through inhibition of acetylcholinesterase (AChE) being well known over the years, some chronic adverse health effects indicate the involvement of additional pathways. Oxidative stress is among the most intensively studied. Overstimulation of cholinergic and glutamatergic nervous system is followed by intensified generation of reactive species and oxidative damage in many tissues. In this review, the role of oxidative stress in pathophysiology of OP poisoning and the influence of commonly used medical interventions on its levels are discussed. Current standardized therapy of OP intoxications comprises live‐saving administration of the anticholinergic drug atropine accompanied by oxime AChE reactivator and diazepam. The capability of these antidotes to ameliorate OP‐induced oxidative stress varies between both therapeutic groups and individual medications within the drug class. Regarding oxidative stress, atropine does not seem to have a significant effect on oxidative stress parameters in OP poisoning. In a case of AChE reactivators, pro‐oxidative and antioxidative properties could be found. It is assumed that the ability of oximes to trigger oxidative stress is rather associated with their chemical structure than reactivation efficacy. The data indicating the potency of diazepam in preventing OP‐induced oxidative stress are not available. Based on current knowledge on the mechanism of OP‐mediated oxidative stress, alternative approaches (including antioxidants or multifunctional drugs) in therapy of OP poisoning are under consideration.