bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kurkumin Meningkatkan Sensitivitas Sel Kanker Payudara terhadap Tamoksifen Melalui Penghambatan Ekspresi P-glikoprotein dan Breast Cancer Resistance Protein
Authors: Sianipar Erlia Anggrainy , Louisa Melva , Wanandi Septelia Inawati 
Published: May 2018

The decreasing of sensitivity or resistance to tamoxifen occured after long-term treatment in breast cancer. One of the major factor in tamoxifen resistance is over expression of efflux transporter P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). Curcumin has known as inhibitor of P-gp and BCRP. The addition of curcumin to the tamoxifen resistant cells is expected to increase the sensitivity of breast cancer cells to tamoxifen. This study aim to know the effect of curcumin in increasing the cell sensitivity to tamoxifen through inhibition of P-gp and BCRP transporter efflux. MCF-7 breast cancer cell line was induced with tamoxifen 1 µM for 10 passage (MCF-7(T)), then cell viability and mRNA expression of P-gp and BCRP were analyzed. To the MCF-7(T) cells, curcumin was given at of 5/10/20 µM with or without tamoxifen for 5 days and cell viability and mRNA expression of P-gp and BCRP were analyzed on day 5th. As positive control, verapamil 50 µM was used as P-gp inhibitor, ritonavir 15 µM and nelfinavir 15 µM were used as BCRP inhibitor. The results showed that MCF-7(T) cells sensitivity to tamoxifen decreased with 11.8 times, the cell viability increased 10.82 fold and mRNA expression of P-gp and BCRP increased 4.04 fold. Then after administration of curcumin with or without tamoxifen for 5 days, the cell viability and the mRNA expression of P-gp and BCRP decreased. As conclusion, curcumin increased the sensitivity of MCF-7(T) to tamoxifen characterized by the decreasing of cell viability and mRNA expression of P-gp and BCRP. However, the administration of combination of curcumin with tamoxifen was more potent than just curcumin. The increased sensitivity was estimated at least partly through the inhibition of P-gp and BCRP mRNA expression by curcumin
Uji Pendahuluan Anti-biofilm Esktrak Teh Hijau dan Teh Hitam Pada Streptococcus mutans melalui Metode Microtiter Plate
Authors: Arjuna Andi , Pratama Winda Setya , Sartini Sartini , Mufidah Mufidah 
Published: May 2018

Tea (Camellia sinensis L.) has an activity as an antibacterial, widely studied to plankton cells, without further researching into biofilm cell. Therefore, this research had been conducted to initially evaluate the activity of green- and black-tea extracts in inhibiting Streptococcus mutans biofilm. Green and black tea leaves were extracted using 70% methanol. Determination of MIC was subsequently performed by microdilution method. Next, the biofilm formation and inhibition were run through microtiter plate method using flexible U-bottom PVC 96 wells, which then observed using microplate reader on λ = 515 nm. As The results, MIC for green and black tea extract stood at 4 mg/mL, 6 mg/mL respectively. The biofilm inhibitory activity of black tea extract was at 8 and 10 mg/mL inhibiting 6 % and 12.5 % S. mutans. Green tea extract showed that concentration of 4 to 10 mg/mL was able to inhibit biofilm growth by 24%; 45%; 48% and 53%. Thus, through microtiter plate assay, it could be concluded that tea extract has potent antibiofilm to S. mutans, where green tea extract has better activity than black tea extract.
Prevalência de excesso de peso e fatores associados em uma região metropolitana do nordeste brasileiro
Authors: Oliveira Ariel Figueiredo , Araújo Júnior Augusto César Santiago , Cruz Josilda Ferreira , Cruz Mário Augusto Ferreira , Santana Demetrius Silva de , Rezende Karla Freire , Oliveira Cristiane Costa da Cunha , Lima Sônia Oliveira 
Published: May 2018

Objetivo: Identificar o perfil clínico e sociodemográfico em adultos com excesso de peso na cidade de Aracaju, Sergipe. Estudo transversal, descritivo tipo survey, com abordagem analítica quantitativa. Métodos: Amostra com 690 indivíduos que procuraram de forma aleatória quatro centros de referências para a realização de exame de ultrassonografia abdominal. A aferição de medidas antropométricas entre julho de 2013 a julho de 2014. Foram analisadas as variáveis idade, sexo, renda, escolaridade, comorbidades, circunferência da cintura e índice de massa corpórea (IMC). O programa estatístico utilizado foi o SPSS 22.0 e o nível de significância p<0,05. Resultados: Foram avaliadas 494 mulheres (71,6%) e 196 homens (28,4%). Média de idade dos pacientes foi de 39,4 anos e, naqueles com obesidade foi de 42,3 anos. Em relação ao IMC, 52,9% dos indivíduos eram normais, 31,2% tinham sobrepeso, e o restante obesidade grau I (10,4%), grau II (4,5%) ou grau III (1,0%). O IMC foi significativamente maior no grupo dos hipertensos (p=0,001), no grupo de menor escolaridade (p=0,004), bem como no de maior renda (p=0,003). A circunferência da cintura apresentou média de 104,9cm em obesos. Conclusão: Observaram-se altas prevalências de excesso de peso nos adultos pesquisados consoante a tendência epidemiológica nacional, o que permite classificar a situação como um problema de saúde pública no município avaliado.
MODEL DDST(DENVER DEVELOPMENT SCREENING TEST) UNTUK MONITORING PERKEMBANGAN ANAK BERBASIS EXPERT SYSTEM
Authors: Latubessy Anastasya , Wijayanti Esti 
Published: May 2018

Pertumbuhan dan perkembangan anak atau biasanya disebut tumbuh kembang anak menjadi perhatian bagi setiap orang tua. Pertumbuhan lebih melihat pada perubahan fisik, proses bertambahnya ukuran tubuh dengan adanya pembesaran sel-sel tubuh. Sedangkan perkembangan itu sendiri merupakan hasil dari proses tingkat kematangan seorang anak. Menjadi harapan setiap orang tua agar tumbuh kembang anaknya dapat berjalan dengan baik. Pada kasus-kasus tertentu seorang anak dapat memiliki perilaku penyimpangan dalam perkembangannya. Orang tua harus dapat menyadari pola penyimpangan tersebut lebih dini. Namun, tidak semua orang tua mengetahui ciri-ciri penyimpangan perkembangan anak. Salah satu tes yang dapat digunakan untuk mengukur perkembangan anak yaitu, DDST(Denver Development Screening Test). Dengan menggunakan 121 jenis tugas perkembangan yang terbagi atas empat sektor yaitu, personal social, fine motor adaptive, bahasa dan grass motor. Tes yang masih bersifat manual ini kemudian dimodelkan dengan menggunakan salah satu metode pemodelan expert system yaitu backward chaining. Dari hasil akhir penelitian ini adalah sebuah model yang dapat digunakan untuk menunjukkan perkembangan seorang anak.
PEMANFAATAN LIMBAH PLASTIK SEBAGAI ENERGY ALTERNATIF
Authors: Nugroho Arif Setyo , Rahmad Rahmad , Suhartoyo Suhartoyo 
Published: May 2018

Pyrolisis pada suhu rendah plastik PP akan menghasilkan minyak sedikit. Plastik PP memiliki struktur ikatan kristal teratur, lebih sulit terdekomposisi jika dibandingkan dengan plastik PE yang memiliki struktur rantai yang panjang dan bercabang. Hasil pengujian didapat bahwa pada suhu 4000C jumlah minyak, gas, dan padatan yang dihasilkan berturut-turut sebesar 52%, , 15% dan 33 %. Minyak yang dihasilkan lebih banyak dibandingkan dengan temperature reactor 200 OC. Hasil pada suhu 2000C jumlah minyak, gas, dan padatan yang dihasilkan berturut-turut sebesar 30%, 10%, dan 60 %. Rata- rata waktu penyalaan generator berbahan bakar gasolin adalah 9,25 menit dengan berbagai macam variasi pembebanan. Waktu terlama penyalaan generator adalah 11.09 menit dengan bahan bakar campuran gasolin + minyak pyrolisis ( temperatur 300oC) dan paling boros adalah 9.02 menit berbahan bakar 100 % minyak hasil pyrolisis.
RANCANG BANGUN SISTEM INFORMASI PARIWISATA DAN BUDAYA BERBASIS WEB MENGGUNAKAN GOOGLE API PADA KANTOR PARIWISATA DAN KEBUDAYAAN KABUPATEN BLORA
Authors: Danang Danang , Febryantahanuji Febryantahanuji , Maryati Rima Febriana 
Published: May 2018

Perkembangan teknologi komputer yang semakin pesat media internet merupakan salah satu penyampaian informasi yang sangat efektif. Melalui internet berbagai macam informasi dari berbagai macam bidang didapatkan secara cepat. Internetpun menjadi bagian penting sebagai wadah atau media promosi. Dengan faktor kelebihan internet tersebut, peneliti mencoba untuk memberikan informasi tentang keberadaaan pariwisata dan budaya yang ada di Blora agar diketahui oleh masyarakat kota Blora pada khususnya dan masyarakat luar kota Blora pada umumnya dengan mudah dan hemat waktu. Kabupaten Blora merupakan kabupaten yang mempunyai potensi wisata yang meliputi wisata belanja, wisata alam, wisata budaya maupun kuliner. Wisata belanja di Blora sangat beragam bagi para wisatawan yang akan berbelanja produk kerajinan dan sebagainya. Wisata budaya yang ditawarkan berupa tradisi dan adat istiadat serta keunikan khas yang ada di Blora. Sedangkan wisata kuliner yang terdapat di Blora berupa makanan khas dan jajanan khas Blora. Perancangan sistem ini dibuat melalui beberapa tahap, yaitu dari mulai menganalisa permasalahan, desain sistem, dan sampai ke tahap pengujian. Software pendukung yang digunakan adalah Apache, Macromedia Dreamweaver MX dan PHP sebagai server side- scripting dan output yang dihasilkan berupa sebuah website yang menyediakan informasi dan dapat tercapai peningkatan yang optimal dalam bidang pariwisata dan budaya di Kabupaten Blora yang dapat lebih mengangkat citra Kabupaten Blora sebagai kota wisata dan budaya. Kata kunci: teknologi, informasi, pariwisata, budaya, Blora.
PERANCANGAN SISTEM INFORMASI PENGGUNAAN DANA BANTUAN OPERASIONAL SEKOLAH TERPADU DENGAN METODE BERORIENTASI OBJEK
Authors: Rasminto Hendri , Kuncoro Arsito Ari , Santoso Budi 
Published: May 2018

Penerapan Teknologi Informasi saat ini telah menyebar hampir di semua bidang tidak terkecuali dalam penggunaan Dana Operasional Sekolah (BOS) mungkin seluruh kegiatan penggunaan dana bantuan operasional memanfaatkan teknologi informasi. Bantuan Operasional Sekolah adalah program pemerintah yang pada dasarnya adalah untuk penyediaan pendanaan biaya operasi nonpersonalia sekolah bagi satuan pendidikan dasar sebagai pelaksana program wajib belajar 9 tahun. Dengan adanya dana Bantuan Operasional Sekolah ini, maka akan lebih meringankan beban para orangtua siswa dengan dihilangkannya biaya SPP bulanan. Masalah yang sering terjadi dalam penggunaan dana bantuan sekolah adalah sistem yang ada sekarang ini masih kesulitan mengontrol anggaran operasional setiap Triwulannya, sehingga masih banyak terdapat anggaran yang melibihi dari anggaran yang ditetapkan sebelumnya di Rencana Kegiatan Anggaran Madrasah (RKAM). Dengan penelitian ini, peneliti merancang sistem informasi Penggunaan Dana Bantuan Sekolah (BOS Terpadu berbasis web dengan Metode Berorientasi Objek menggunakan software Adobe Dreamweaver. Diharapkan TU dan bendahara BOS dalam memberikan informasi penggunaan Dana BOS menjadi lebih terstruktur, lebih baik dan lebih cepat dalam menyusun laporan triwulan, serta mampu menghasilkan informasi dan pelaporan yang tepat dan akurat. Pertimbangan penggunaan web juga sebagai pemantauan langsung komite sekolah dan guru dalam penggunaan Dana Bantuan Sekolah supaya tidak terjadi penyelewengan anggaran, sehingga dengan adanya sistem ini dapat memberikan informasi penggunaan Dana Bantuan Sekolah dengan lebih cepat dan akurat. Kata kunci: sistem informasi, RKAM, BOS, web.
MONITORING BABY INCUBATOR SENTRAL DENGAN KOMUNIKASI WIRELESS
Authors: Utomo Ary Sulistyo , Satrya Antonius Bagus , Tapparan Yandri 
Published: May 2018

Baby Incubator adalah suatu alat yang digunakan untuk menghangatkan bayi yang baru lahir dan sering digunakan pada bayi yang lahir secara premature. Baby Incubator ini juga berfungsi menjaga kehangatan, kelembaban tubuh bayi serta dapat mencegah terjadinya infeksi pernapasan pada bayi dan untuk mengisolasi bayi yang baru lahir terutama bayi yang lahir secara premature. Dengan kondisi tersebut diperlukan pengamatan atau monitoring terhadap bayi yang berada di baby incubator. Pembuatan baby incubator dengan sistem monitoring sentral ini digunakan untuk pemantauan kondisi lingkungan yang terdapat di ruang incubator. Baby Incubator ini terdiri dari rangkaian arduino nano, rangkaian pengendali heater dan wireless serial dengan modul kyl 1020. Prinsip kerja pemanasan menggunakan heater, yang dapat dikendalikan sudut penyalaan dari heater tersebut. Pembuatan aplikasi monitoring suhu menggunakan Microsoft Visual Studio. Hasil pengamatan disimpan pada database menggunakan microsoft acces. Dari hasil percobaan yang dilakukan jarak yang dapat dicapai untuk pengiriman data dalam kondisi line of sight (LOS) adalah 0-220m sedangkan untuk Non-Line of sight (NLOS) adalah 180m. Pengujian suhu ruang baby incubator menggunakan termometer sebagai perbandingan dengan nilai suhu yang dibaca pada alat. Dari pengukuran diperoleh tingkat perbedaan 0% pada suhu 30oC dan 2,8% pada suhu 37oC.
COMPARISON BETWEEN BRAZIL AND THE 30 MOST INNOVATIVE COUNTRIES IN THE WORLD
Authors: Moser Marisa , Aparecido de Oliveira Mauri 
Published: May 2018

Innovation can be defined as the implementation of a new or significantly improved product (good or service), or a process, a new marketing method, a new organizational method in business practices, workplace organization, or external relations. This innovation can be measured by several factors such as investments in research and development, the concentration of high-tech companies traded on the stock exchange, among others. The present study aims to perform a cluster analysis to investigate the behavior of the most innovative countries when compared to Brazil. The study contemplates a historical series from the years 2012 to 2015 of the 30 most innovative countries in the world having been added to Brazil. In addition, a series of macroeconomic, political and social variables.
Concurrent Scanning for High Quality Hand Over Support in Mobile WiMAX Networks
Authors: Reddy Prabhu , Shankar Arathi R , Rao V.sambasiva 
Published: May 2018

Mobile WiMAX is IEEE 802.16e standard established for mobile broadband wireless access (BWA). Mobility in WiMAX system is an important issue when the mobile station (MS) moves and be handover between base stations (BSs). This issue causes an unnecessary neighboring BS scanning and association, handover delay, and MAC overhead which may affect real-time applications.
The MS movement direction prediction (MMDP) based MS scanning is used to reduce the number of scanningâ€™s required in mobile WiMAX handover process. In this paper with reduction in number of scanningâ€™s we propose to reduce the scanning delay required for evaluated two best target BSs by using concurrent scanning process. Network issues like ideal sectors in WiMAX 2 (IEEE 802.16m), network congestion and fast change in RSS are important parameters which can affect the QoS. With this proposed model we are able to provide the high quality hand over support in mobile WiMAX wherein we are able to solve the above stated network problems. Here on using the concurrent scanning process the authors are able to reduce the scanning delay by 40%. As a part of this paper, network layer parameters called routing protocols are analyzed for hand over support. This analysis shows an efficient routing protocol for real time application and the best effort service. This reviles that fisheye protocol is better to use for smaller network and LANMAR for the larger networks in real time application and IERP protocol is good for best effort services.
AN EFFICIENT Hybrid Swarm Intelligence Technique for Solving Integer Programming
Authors: Ismail Mahmoud M. , El-henawy Ibrahim M. 
Published: May 2018

In this paper, a hybridization of two different swarm intelligent approaches, stochastic diffusion search, and particle swarm optimization techniques is presented Â for solving integer programming problems. The hybrid implementation allows us to avoid certain drawbacks and weaknesses of each algorithm, which means that we are able to find an optimal solution in an acceptable computational time. Our hybrid implementation allows the IP algorithm to reach the optimal solution in a considerably shorter time than is needed to solve the model using the entire dataset directly within the model. Our hybrid approach outperforms the results obtained by each technique separately. It is able to find the optimal solution in a shorter time than each technique on its own, and the results are highly competitive with the state-of-the-art in large-scale optimization. Furthermore, according to our results, combining the PSO with SDS approach for solving IP problems appears to be an interesting research area in combinatorial optimization.Â
Design and Development of Apriori Algorithm for Sequential to concurrent mining using MPI
Authors: Pol Urmila 
Published: May 2018

Owing to the conception of big data and massive data processing there are increasing owes related to the temporal aspects of the data processing. In order to address these issues a continuous progression in data collection, storage technologies, designing and implementing large-scale parallel algorithm for Data mining is seen to be emerging in a rapid pace. In this regards, the Apriori algorithms have a great impact for finding frequent item sets using candidate generation. This paper presents highlights on parallel algorithm for mining association rules using MPI for passing message base in the Master-Slave based structural model.
Development of Networks Model in The Serious Game of Agribusiness Management for Decision Making
Authors: Bukhori Saiful , Uta Wiji , Andrianto Anang 
Published: May 2018

This research developed a decision-making process in the agribusiness management system and analyzed the behavior of fixed point for identifying the position of agribusiness interaction. Agribusiness is represented as node that work together in the marketÂ to maintain the stability of market. Based on agribusiness management and data modeling, there are four conditions of the inter-company networks: (1) mutual dependence, (2) mutual independence, (3) unbalanced dependece, (4) unbalanced independence. The experiment resultsÂ are the mutual dependence conditioan the fixed point towards stable value come near 0. The mutual independence, fixed point towards stable value, but stability value still not yet comeÂ near 0. The unbalanced dependece, fixed pointÂ oscillate and convergence. While the unbalanced independence, fixed point start oscillation.
Global Prediction algorithms and predictability of anomalous points in a time series
Authors: Tripathi K C , Agarwal Rashi , Hrisheekesha P N 
Published: May 2018

The Indian Ocean Dipole (IOD) event of 1997 had significant impacts on regional climate variability as it produced large Sea Surface Temperature (SST) anomalies in the Indian Ocean (IO). This dipole mode accounted for about 12% of the sea surface temperature variability in the Indian Oceanâ€”and, in its active years, also causes severe rainfall in eastern Africa and droughts in Indonesia. There have been speculations that the El-nino and Intra-Seasonal Oscillations (ISOs) act as stochastic forcing to reinvigorate the natural damped mode and hence contribute to the development of the IOD.Â In the present paper we have statistically investigated whether the formation of the dipole was an anomalous phenomenon with respect to the time series generated by the deterministic laws of the system governing the IO SST or was this event a consequence of the dynamics of the system itself. For this, we have used the a global prediction algorithm i.e. linear regression. Prediction errors of global prediction algorithms such as the regression and Artificial Neural Network (ANN) models at various points in time contain important information regarding the statistical nature of the data. On the basis of the error analysis it is found that the occurrence of the IOD is a consequence of the state of the SST system as a whole together with the evolution laws. The role of ISO in providing external forcing to the dipole is investigated by analyzing the prediction errors of the global prediction algorithms for processes at intra-seasonal time scales. It is concluded that the Intra-Seasonal Oscillations may provide the stochastic forcing to the IOD.Â
Cost Analysis and Simulation of Decimator for Multirate Applications
Authors: Mehra Rajesh , Singh Lajwanti 
Published: May 2018

In this paper, a decimator design has been presented for multirate digital signal processing. Â The decimator design has been analysed and simulated for cost comparison in terms of multipliers and MPIS. Two structures Â namely Transposed Direct form and Symmetric Direct form have been used performance and Â resource consumption analysis. The decimators have been designed Â & simulated using MATLAB. It can be observed from the simulated results that symmetric structure comsumes almost 50% less multipliers and MPIS compared to transposed structure. So the symmetric structure based decimator is suitable to provide cost effective solution
Algorithm based on Histogram and Entropy for Edge Detection in Gray Level Images
Authors: El-Sayed Mohamed A. 
Published: May 2018

Edge detection and feature extraction are widely used in image processing and computer vision applications. Most of the traditional methods for edge detection are based on the first and second order derivatives of gray levels of the pixels of the original image utilizing 2D spatial convolution masks to approximateÂ the derivative. In this paper we present an algorithm for edge detection in gray level images. The main objective is to solve the previous problem of traditional methods with generate suitable quality of edge detection. Our new algorithm is based on two definitions of entropy: Shannonâ€™s classical concept and a variation called Tsallis entropy. TheÂ novel approach utilizing Subextensive Tsallis entropy rather than the evaluation of derivatives of the image in detecting edges in gray level images has been proposed. Here, we have used a suitable threshold value to segment the image and achieve the binary image. The effectiveness is demonstrated by using many different kinds of test images from the real-world and synthetic images. The results of this study were quite promising.
Comparative Analysis of Color Video Enhancment Techniques
Authors: Sunakara Rajeev , Sankar P.Ravi 
Published: May 2018

Contrast enhancement has an important role in image processing applications. This paper presents a color enhancement algorithm based on adaptive filter technique. First, the proposed method is divided into three major parts: obtain luminance image and backdrop image, adaptive modification and color restoration. different traditional color image enhancement algorithms, the adaptive filter in the algorithm takes color information into consideration. The algorithm finds the significance of color information in color image enhancement and utilizes color space conversion to obtain a much better visibility. In the practical results, the proposed method reproduces better enhancement and reduce the halo distortion compared with the bilateral methods.