bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors which Influence the Levels of ST-2, Galectin-3 and MMP-9 in Acute Coronary Syndrome
Authors: Goenka Luxitaa , Jha Durga , Sharma Masum , Dhandapani V.E. , George Melvin 
Published: July 2019

Background:
Several cardiac biomarkers are being studied to explore their potential in
the prognostication of Acute Coronary Syndrome (ACS). However, there are limited studies
exploring the relationship between these biomarkers and clinical, laboratory and demographic
characteristics.

Objective:
We sought to determine the factors which influence the concentration of novel cardiac
biomarkers such as Galectin-3, suppression of tumorigenicity-2 (ST-2) and Matrix
Metallopeptidase-9 (MMP-9) in patients with ACS.

Methods:
A total of 122 patients with ACS were enrolled in the study. The study patients were
categorized into two groups namely: STEMI (n=58) and NSTEMI/UA (n=64). Plasma samples
were used to determine the level of biomarkers, Galectin-3 and ST-2, and serum samples were used
to determine the levels of MMP-9 using the Enzyme-linked immunosorbent assay (ELISA). The
association between the plasma and serum levels of biomarkers and, demographic, clinical and
laboratory variables were determined. Statistical analyses for the study were performed using SPSS
16.0 software (SPSS Inc., Chicago, IL, USA).

Results:
Elderly aged [0.107 (0.012-0.969); p=0.047] patients had higher ST-2. Galectin-3 was
higher among female patients [3.693(1.253-10.887); p=0.018] and patients with low left ventricular
ejection fraction [2.882 (1.041-7.978); p=0.042]. Patients with lower body mass index [3.385
(1.241-9.231); p=0.017], diabetes [3.650 (1.302-10.237); p=0.014] and high total leukocyte count
[2.900 (1.114-7.551; p=0.029] had higher MMP-9 levels.

Conclusion:
The concentration of galectin-3, ST-2 and MMP-9 are independently influenced by
demographic, clinical and laboratory characteristics. It is estimated that these factors should be
accounted for when interpreting the results of the biomarker assays.
Inflammatory Response and Endothelial Dysfunction Following Cardiopulmonary Bypass: Pathophysiology and Pharmacological Targets
Authors: Giacinto Omar , Satriano Umberto , Nenna Antonio , Spadaccio Cristiano , Lusini Mario , Mastroianni Ciro , Nappi Francesco , Chello Massimo 
Published: July 2019

Background:
Endothelial injury occurring during cardiopulmonary bypass is a major contributing
factor in the development of organ dysfunction, which leads to many of the postoperative
complications occurring during cardiac surgery.

Objective:
This narrative review aims to summarize the main mechanisms of cardiopulmonary bypass -
related disease, evaluating the unfavorable events leading to tissue injury, with a description of current
pharmacologic and non-pharmacologic mechanisms to reduce CPB-related injury.

Methods:
A Medline/Pubmed/Scopus search was conducted using clinical queries with the key terms
"cardiac surgery", “cardiopulmonary bypass”, "inflammation" and “endothelial injury”, and related
MeSH terms, until July 2019. The search strategy included meta-analyses, randomized controlled trials,
clinical trials, reviews and pertinent references. Patents were searched using the same key terms from
https://patents.google.com/, www.uspto.gov, and www.freepatentsonline.com.

Results:
In this review, we discuss the current knowledge of the mechanisms of vascular endothelial
cell injury, the acute inflammatory response, and the regulatory factors that control the extent of vascular
injury during extracorporeal circulation, summarizing the main target of anti-inflammatory pharmacologic
and non-pharmacologic strategies.

Conclusion:
Inflammatory response and endothelial dysfunction following cardiopulmonary bypass are
the prices to pay for the benefits offered during cardiac surgery procedures. Counteracting the detrimental
effect of extracorporeal circulation appears to be crucial to improve clinical outcomes in pediatric
and adult cardiac surgery. The intrinsic complexity and the tight interplay of the factors involved
might require a holistic approach against inflammation and endothelial response.
Primary Healthcare Data Management Practice and Associated Factors: The Case of Health Extension Workers in Northwest Ethiopia
Authors: Yitayew Segenet , Asemahagn Mulusew A. , Zeleke Atinkut A. 
Published: July 2019

Background:
Collecting quality and timely healthcare data is crucial to improve health service performance.

Objective:
This study aimed at assessing data management practice and associated factors among health extension workers in East Gojjam zone, Northwest Ethiopia.

Materials and Methods:
An institution based cross-sectional study was conducted in 2014 among 302 health extension workers. Data were collected using a self-administered questionnaire and analyzed using SPSS version 20. The study objectives were described by descriptive statistics, and factors in data management were identified by multivariable logistic regression analysis.

Results:
A total of 302 health extension workers participated in the study. About 47.4% and 53.3% of respondents had good data management knowledge and practice, respectively. Inaccessibility of transportation, communication services, reference materials, and data collection/reporting formats were the mentioned challenges. Workload, data management knowledge, supervision, urban residence, reference materials access and clarity of formats were positively associated with better data management practice (p <0.05).

Conclusion:
Based on this study, the data management practice of health extension workers was low. Factors for low data management practice were organizational and technical related. Addressing knowledge gaps through professional development and improving supportive supervision are crucial to solve the problem.
Urtica dioica in the Management of Benign Prostate Hyperplasia (BPH)
Authors: Mahboubi Mohaddese 
Published: July 2019

Background::
Benign Prostatic hyperplasia (BPH) is known as a disease prevalent in men
after the age of 50 years old. Ninety percent of men with the age of 80 years and over have BPH.
BPH is associated with functional problems like dysuria, nocturia, polyuria, urinary incontinence
and recurrent urinary tract infections. Urtica dioica or nettle is a popular medicinal plant for management
of BPH in men.

Objective::
This article evaluates the efficacy and safety of nettle and its related possible mechanisms
in the management of BPH.

Methods::
For the preparation of this manuscript, all the information was gathered from accessible
and inaccessible resources (Web, Books, Thesis, etc.).

Results::
The results of preclinical and clinical studies confirmed the efficacy of nettle roots extracts
(methanol, ethanol, and petroleum ether) in the improvement of BPH in term of IPSS score, and patient's
life quality. An increase in mean and maximum urinary flow rates and a reduction in prostate
volume and residual urine level were observed after treatment with nettle extract. Nettle roots should
be used for 6-12 months as its use is possible for a long time without any serious adverse effects.

Conclusion::
Designing the clinical trials to compare the efficacy of different extracts from roots or
leaves and investigation of molecular mechanisms of action could be the approaches for future.
Chemically Nano-Engineered Theranostics for Phytoconstituents as Healthcare Application
Authors: Gilani Sadaf Jamal , Beg Sarwar , Kala Chandra , Nomani Mohammed Shivli , Mahapatra Debarshi Kar , Imam Syed Sarim , Taleuzzaman Mohamad 
Published: July 2019

Background:
Nanomedicines are capable of disease diagnosis, drug delivery, and in monitoring
the therapeutic result to provide appropriate tasks towards research goals. The best therapeutic
pattern can be achieved by developing a theranostic nanomedicine, which is an emerging field. It has
the advantage of loading phytoconstituents as drugs and is useful for both imaging and therapeutic
function.

Methods:
Nowadays, the design of a novel drug delivery system of the herbal constituent is usually
done through the nanotechnology approach. This technique increases the biological activity and
counters the puzzles associated with plant medicines. Traditional medicine integration with nanocarriers
as an NDDS is very essential in the management of chronic diseases such as hypertension,
diabetes, and cancer.

Results:
The nanotechnology combination with plant science is a green revolution with a practical approach
for decreasing the therapeutic side effects. The object of the study is to review herbal
nanomedicine with an enhanced therapeutic profile and less toxicity.

Conclusion:
The development of herbal theranostic nanoformulation is very useful for the treatment
of different diseases.
Using Hyperbolic Shear Deformation Theory for Study and Analysis, the Thermal Bending of Functionally Graded Sandwich Plate Properties
Authors: Khaled Bendahane , Otbi Bouguenina , Allel Mokaddem , Bendouma Doumi , Khalil Belakhdar 
Published: July 2019

Background:
Several studies and patents have been carried out on the realization and optimization
of structures and structural elements subjected to several-weights-critical-applications. Among
the structures optimized in engineering, there are sandwich structures that are mainly used to react under
these conditions.

Objective:
In this article, we have investigated the thermal bending response of simply supported Functionally
Graded Sandwich Plate (FGSP).

Methods:
Using simple Hyperbolic Shear Deformation Theory (HSDT). A type of FGSP with both
functionally graded materiel FGM face and ceramic hard core are considered. Based on the principle of
virtual work, the governing equations are derived and then these equations are solved via Navier procedure.
Analytical solutions are obtained to predict the deflection, axial and shear stress of FGSP.

Results:
To verify the efficiency of the present method a comparison with existing literature and patents
results is employed. The influence of the plate aspect ratio, the relative thickness, the gradient index,
the sandwich plate schemes, and the thermal loading conditions on the bending of FGSP are investigated.

Conclusion:
A good agreement is obtained between present results and the existing literature solutions.
It can be concluded that the proposed theory is accurate and simple in solving the thermoelastic bending
behavior of functionally graded sandwich plates. Various patents have been discussed.
Assessment of the Quality of Randomized Clinical Trials Published by Iranian Researchers in Persian Internal Journals in 2014
Authors: Rafiei Mohammad , Feizi Awat , Shariatpanahi Seyyed P. , Hamraz Iman , Habibi Danial 
Published: July 2019

Introduction:
A randomized clinical trial is known as the best and most effective way
to assess the effects of interventions if it is properly planned and implemented. The purpose of this
study was to evaluate the quality of clinical trials published in Persian internal journals by Iranian
researchers.

Method:
In this cross-sectional study, all the clinical trials published by Iranian researchers in the
Iranian Journals in 2014, were evaluated according to entry criteria and finally 587 included articles
were reviewed and their quality was evaluated by using Consolidated Standards of Reporting
Trials (CONSORT) checklist.

Results:
The results revealed that the mean±SD adherence to the CONSORT checklist’s item in
our included articles was 59.61±24.99. The lowest adherence to the items was seen for random allocation
(76.1%), description of the sampling method (70.1%) and presenting RCT code registration
(60.4%), respectively. The highest adherence was observed for title suitability (96%), appropriate
presentation time and place of study (84.2%), a suitable expression of study participants
(82.8%) and time duration of the study (82.3%).

Conclusion:
The adherence to the various items of CONSORT checklist in Iranian Persian language
journals was not in satisfactory status. In this regard, the CONSORT checklist needs to be
carefully followed for conducting and reporting RCTs by Iranian researchers.
Disparities in Electronic Patient Portal Use in Prenatal Care: Retrospective Cohort Study
Authors: Ukoha Erinma P , Feinglass Joe , Yee Lynn M 
Published: July 2019

Background
Electronic patient portals are websites that provide individuals access to their personal health records and allow them to engage through a secure Web-based platform. These portals are becoming increasingly popular in contemporary health care systems. Patient portal use has been found to be beneficial in multiple specialties, especially in the management of chronic disease. However, disparities have been identified in portal use in which racial and ethnic minorities and individuals with lower socioeconomic status have been shown to be less likely to enroll and use patient portals than non-Hispanic white persons and individuals with higher socioeconomic status. Electronic patient portal use by childbearing women has not been well studied, and data on portal use during pregnancy are limited.

Objective
This study aimed to quantify the use of an electronic patient portal during pregnancy and examine whether disparities related to patients’ demographics or clinical characteristics exist.

Methods
This was a retrospective cohort study of women who received prenatal care at an academic medical center from 2014 to 2016. Clinical records were reviewed for portal use and patient data. Patients were considered enrolled in the portal if they had an account at the time of delivery, and enrollees were compared with nonenrollees. Enrollees were further categorized based on the number of secure messages sent during pregnancy as active (≥1) or inactive (0) users. Bivariable chi-square and multivariable Poisson regression models were used to calculate the incidence rate ratio of portal enrollment and, if enrolled, of active use based on patients’ characteristics.

Results
Of the 3450 women eligible for inclusion, 2530 (73.33%) enrolled in the portal. Of these enrollees, 72.09% (1824/2530) were active users. There was no difference in portal enrollment by maternal race and ethnicity on multivariable models. Women with public insurance (adjusted incidence rate ratio; aIRR 0.60, 95% CI 0.49-0.84), late enrollment in prenatal care (aIRR 0.78, 95% CI 0.69-0.89 for second trimester and aIRR 0.50, 95% CI 0.39-0.64 for third trimester), and high-risk pregnancies (aIRR 0.82, 95% CI 0.75-0.89) were significantly less likely to enroll. Conversely, nulliparity (aIRR 1.10, 95% CI 1.02-1.20) and having more than 8 prescription medications at prenatal care initiation (aIRR 1.19, 95% CI 1.06-1.32) were associated with greater likelihood of enrollment. Among portal enrollees, the only factor significantly associated with active portal use (ie, secure messaging) was nulliparity (aIRR 1.11, 95% CI 1.01-1.23).

Conclusions
Among an obstetric population, multiple clinical and socioeconomic factors were associated with electronic portal enrollment, but not subsequent active use. As portals become more integrated as tools to promote health, efforts should be made to ensure that already vulnerable populations are not further disadvantaged with regard to electronic-based care.
Desempleo en América Latina: ¿flexibilidad laboral o acumulación de capital?
Authors: García Luis Fernando , Cruz Blanco Moritz 
Published: July 2019

El desempleo en América Latina ha tenido una disminución sustancial durante el periodo 2000-2013. Desde el punto de vista teórico convencional, lo anterior sería consecuencia de las reformas orientadas a flexibilizar el mercado de trabajo. Por otro lado, la visión post-keynesiana sustentaría que la caída de la tasa de desempleo se debe al aumento de la acumulación de capital. El presente documento intenta conocer cuál de estas visiones teóricas es apoyada por la evidencia empírica. Los resultados del panel de datos sugieren que la acumulación de capital es la variable que explica mayormente el desempeño del desempleo. La recomendación de política de esta evidencia es mantener en crecimiento la inversión a través de instrumentos que estimulen la demanda efectiva.
El Estado y el capital financiero en Argentina entre 2002 y 2012. La deuda pública
Authors: Bordon Marisa 
Published: July 2019

Con el fin de encontrar indicios acerca de la posición del capital financiero en la dinámica económica argentina entre 2002 y 2012, se han analizado algunos aspectos de su relación con el Estado. El “desendeudamiento” llevó a la desarticulación parcial de la deuda pública como eje de la actividad especulativa, pero conservó su rentabilidad y posición prioritaria en las decisiones de política económica. Por otro lado, la regulación financiera contribuyó a conservar el mecanismo de la deuda y no alteró significativamente la posición central del capital financiero.
Distorsiones y desequilibrios en la dinámica de acumulación de la economía en España
Authors: Mateo Juan Pablo 
Published: July 2019

El presente artículo estudia las distorsiones sectoriales de la dinámica de acumulaciónde capital en España, entre los años de 1999 y 2014, desde un enfoque de economíapolítica. La inversión ha estado impulsada en gran medida por la revalorización de losactivos relacionados con la construcción, lo que ha generado una profunda reconfiguración de la estructura económica. Por lo tanto, se precisa de un estudio desagregado por activos y sectores. El aspecto esencial radica en la composición del capital: los sectores más dinámicos han sido aquéllos con una relativamente baja composición técnica del capital, dando lugar a disminuciones absolutas en la productividad del trabajo, así como un efecto precio que ha distorsionado por completo la reproducción en el tiempo de la economía española.
¿Una renegociación en puerta o una fractura del paradigma?
Authors: Girón Alicia 
Published: July 2019

Hoy es el momento de determinar si los acuerdos de integración impactaron en el desarrollo económico, político y cultural de los países participantes. Acuerdos de integración como el Tratado de Libre Comercio de América del Norte (TLCAN) entre Canadá, Estados Unidos de América y México, y otros acuerdos comerciales que se pactaron a partir de la reestructuración económica y la entonces regionalización, a nivel mundial en la década de los ochenta, son parte del debate nacional y resultado de la “Gran Crisis” y la “Gran Recesión” iniciada hace una década.
“RESISTIR É PRECISO, FAZER NÃO É PRECISO”: AS CONTRARREFORMAS DO ENSINO MÉDIO NO BRASIL
Authors: Ramos Marise Nogueira , Frigotto Gaudêncio 
Published: July 2019

Este artigo trata de resistências dos educadores às contrarreformas que incidiram sobre o ensino médio no Brasil. Fazemos uma reflexão sobre a história dos golpes de Estado realizados pela classe dominante em nosso país e sua relação com a educação. Reiteramos análises de aspectos legais, confrontando-os com as propostas educacionais progressistas, reconhecendo a década de 1980 como um marco na história da educação brasileira. Mostramos como os processos de resistência se fazem na sociedade civil e nas instituições. A vitória de forças de esquerda nas eleições de 2002 abriu caminhos para se confrontar as políticas neoliberais do período de Fernando Henrique Cardoso. O atual governo ilegítimo de Michel Temer ataca violentamente os direitos da classe trabalhadora e, no ensino médio, mais uma vez impede seu avanço conceitual e estrutural, com a atual contrarreforma. Concluímos o artigo defendendo a retomada das lutas em defesa da educação pública universal, gratuita, laica e das concepções da escola unitária e de formação politécnica. Nesses termos, a realização da Conferência Nacional Popular de Educação é mais uma perspectiva de resistência, além da mobilização de toda a sociedade contra o novo regime fiscal e as reformas trabalhista, da previdência e educacional.
A FORMAÇÃO DA CONSCIÊNCIA DE CLASSE DOS SEM-TETO MEDIADA PELA EXPERIÊNCIA NAS OCUPAÇÕES POR MORADIA
Authors: Cunha Clarissa Zagotto da , Machado Vinícius Oliveira , Marsiglia Ana Carolina Galvão 
Published: July 2019

O presente artigo analisa a experiência de formação política de trabalhadores sem-teto em ocupações organizadas por movimentos pela moradia e reforma urbana, tendo como base a revisão bibliográfica. Buscamos demonstrar, a partir da categoria “experiência” trabalhada pelo historiador marxista Edward P. Thompson, como as diversas experiências propiciadas pela participação nas ocupações e no enfrentamento à lógica da cidade do capital possibilitam aos trabalhadores sem-teto construírem uma identidade política. Nesse sentido, o artigo está estruturado em duas partes: a primeira visa explicitar alguns aspectos da cidade capitalista, bem como destacar a urgência da reforma urbana e a legitimidade dos movimentos de luta pela moradia; a segunda destaca o papel da categoria experiência na formação da consciência de classe dos sem-teto.
Metodologia para resolução de problemas de fenômenos físicos com equações diferenciais ordinárias
Authors: Laudares João , Furletti Saulo 
Published: July 2019

Este artigo apresenta uma metodologia para o estudo de Equações Diferenciais Ordinárias (EDO), a partir da Resolução de Problemas privilegiando diversas representações de modelos. Ilustra-se por completo uma resolução, com os passos presentes na proposta metodológica, que direcionaram a análise dos modelos de equações e gráficos dos fenômenos físicos. O referencial teórico parte da matematização de fenômeno físico com Equações Diferenciais pela resolução de problemas, com base nas representações semióticas, diversificação de representações de objetos matemáticos e análise de modelos. A matematização é dimensionada por leis de movimentos, parâmetros quantitativos e qualitativos. Esta metodologia é resultado de um estudo para suporte aos professores e estudantes dos cursos das áreas de Ciências Exatas, que possuem em seus currículos a disciplina de Equações Diferenciais Ordinárias.
Palavras-chave: Resolução de Problemas. Metodologia. Equações Diferenciais.
Produção de textos matemáticos: a comunicação entre professor e crianças
Authors: Menduni-Bortoloti Roberta , Paula Perovano Ana 
Published: July 2019

Durante o processo de alfabetização matemática, a comunicação entre professor e aluno se faz por meio da produção de textos matemáticos. Com o objetivo de analisar a comunicação entre professor e crianças do 1º ano do Ensino Fundamental na produção de textos matemáticos a partir de marcadores, apresentamos, neste trabalho, um recorte dos dados do núcleo de Vitória da Conquista. Esses dados constituem parte do projeto de pesquisa “A alfabetização matemática com o uso de um material didático e a produção de textos matemáticos legítimos por alunos do 1º ano do Ensino Fundamental no estado da Bahia”. Analisamos, sob as lentes bernsteinianas, a comunicação entre professor e aluno numa abordagem de pesquisa qualitativa em que foi utilizado o modelo metodológico da linguagem de descrição. Como resultado, constatamos a necessidade de oportunizar as crianças as produções de seus próprios textos, aproximando-se da aquisição do código, no caso da escrita numérica.
Palavras-chave: Marcadores. Textos Legítimos. Alfabetização Matemática.