bluuebunny/crossref_metadata_2025_split huggingface dataset:
The COMET (Comparison of Operative versus Monitoring and Endocrine Therapy) trial: a phase III randomised controlled clinical trial for low-risk ductal carcinoma in situ (DCIS)
Authors: Hwang E Shelley , Hyslop Terry , Lynch Thomas , Frank Elizabeth , Pinto Donna , Basila Desiree , Collyar Deborah , Bennett Antonia , Kaplan Celia , Rosenberg Shoshana , Thompson Alastair , Weiss Anna , Partridge Ann 
Published: March 2019

IntroductionDuctal carcinoma in situ (DCIS) is a non-invasive non-obligate precursor of invasive breast cancer. With guideline concordant care (GCC), DCIS outcomes are at least as favourable as some other early stage cancer types such as prostate cancer, for which active surveillance (AS) is a standard of care option. However, AS has not yet been tested in relation to DCIS. The goal of the COMET (Comparison of Operative versus Monitoring and Endocrine Therapy) trial for low-risk DCIS is to gather evidence to help future patients consider the range of treatment choices for low-risk DCIS, from standard therapies to AS. The trial will determine whether there may be some women who do not substantially benefit from current GCC and who could thus be safely managed with AS. This protocol is version 5 (11 July 2018). Any future protocol amendments will be submitted to Quorum Centralised Institutional Review Board/local institutional review boards for approval via the sponsor of the study (Alliance Foundation Trials).Methods and analysisCOMET is a phase III, randomised controlled clinical trial for patients with low-risk DCIS. The primary outcome is ipsilateral invasive breast cancer rate in women undergoing GCC compared with AS. Secondary objectives will be to compare surgical, oncological and patient-reported outcomes. Patients randomised to the GCC group will undergo surgery as well as radiotherapy when appropriate; those in the AS group will be monitored closely with surgery only on identification of invasive breast cancer. Patients in both the GCC and AS groups will have the option of endocrine therapy. The total planned accrual goal is 1200 patients.Ethics and disseminationThe COMET trial will be subject to biannual formal review at the Alliance Foundation Data Safety Monitoring Board meetings. Interim analyses for futility/safety will be completed annually, with reporting following Consolidated Standards of Reporting Trials (CONSORT) guidelines for non-inferiority trials.Trial registration numberNCT02926911; Pre-results.
Kandinsky
Authors: White Richard J. 
Published: March 2019

Abstract
In Concerning the Spiritual in Art (1911) and other writings, the artist Wassily Kandinsky (1866–1944) pursues several guiding questions concerning the spiritual aspects of art. For example: What is the relationship between art and spirituality? How does a work of art express spiritual ideas and themes? And would it be helpful to think of the artist as a kind of visionary or a spiritual seer? In this article, I reconstruct Kandinsky’s theory of art and I clarify his understanding of what spirituality is. Then I return to the three guiding questions listed above to consider the relationship between art and spirituality in the light of Kandinsky’s views. I argue that both Kandinsky’s writings and his paintings help to illuminate the spiritual dimension of art, and his pioneering text, Concerning the Spiritual in Art, remains an important starting-point for reflections on this theme.
Peter Howson and the Language of Salvation
Authors: Froehlich Caleb 
Published: March 2019

Abstract
Since his conversion to Christianity in 2001, Peter Howson’s religious paintings have generally been met with critical incomprehension. A case in point was his 2012 exhibition Redemption, where reviewers suggested an irreconcilable incongruity between its grotesque imagery and redemption, the exhibition’s title. In response to this critical bewilderment, the present article argues for the appropriateness of the grotesque in Howson’s depictions of salvation by examining the significance of his conversion experience and providing a more sophisticated and developed analysis of the grotesque as his visual language. More specifically, it utilizes insights from an analysis of the content and practice of the artist’s belief system and a new taxonomy of the grotesque in a close reading of the Hades cycle, featured in Howson’s Redemption exhibition, in order to show how the artist communicates salvation through the grotesque. It is hoped that this article may serve as useful groundwork for other scholars engaging with Howson’s extraordinary religious art.
Climbing to God on “The Burning Ladder”
Authors: Hren Joshua 
Published: March 2019

Abstract
Christian existentialism is a stepping stool by which we can approach Dana Gioia’s poems of doubt. Such poems—and here we will consider just one, “The Burning Ladder”—contain “an essentially religious irruption and claim, an agony of faith, the cry of the subjectivity towards its God,” and evince “a revelation of the person and of his anguish in the face of the nothingness which is non-being in the existent, the ‘crack in the existent’ ”; read alongside crucial works of Christian existentialism and mysticism, Gioia’s poem reveals these cracks as rungs on which the faithful lover can climb to God.
Australian Consumers’ Knowledge and Concern for Animal Welfare in Food Production: Influences on Purchasing Intentions
Authors: Cornish Amelia R. , Ashton Brayden , Raubenheimer David , McGreevy Paul D. 
Published: March 2019

Abstract
Consumers are increasingly concerned about nonhuman animal welfare in food production and, as their awareness continues to rise, demand for welfare-friendly products is growing. The current study explores the Australian market for welfare-friendly food of animal origin by outlining and clarifying how consumers’ welfare concerns affect their purchasing decisions. It reports the findings of an Australian face-to-face survey of consumers’ knowledge of and attitudes to farm animal welfare and their reported purchasing of welfare-friendly animal-derived products. A novel aspect of this survey was its effort to establish consumers’ understanding of welfare-friendly labels, their motivation to purchase welfare-friendly products, and the barriers to doing so. The survey was deployed in four shopping districts in New South Wales, Australia, in 2016. Data were collected from 135 respondents, and the results are discussed below.
Art and the Politics of Eliminating Handicraft
Authors: Beech Dave 
Published: March 2019

Abstract
This essay charts the outlines of the historical transition from the artisanal workshop to the artist’s studio and the transition from the artisan to the artist, not through the transition from patronage to the art market but through an analysis of the transformation of labour’s social division of labour. The essay reassesses the discourses on the artist as genius and the artist as worker through a reinterpretation of the elevation of the Fine Arts above handicraft. This sheds new light, also, on the discourse of deskilling in art. This essay argues that the transition from the artisan to the artist is an effect of the social division of labour in which the knowledge, skills and privileges of the master artisan are distributed among a set of specialists.
Thinking with Kant “beyond” Kant
Authors: Corradetti Claudio 
Published: March 2019

In the following essay, I attempt to reactualize some of Kant’s most fundamental conceptions of a state’s sovereignty and the legitimacy of the cosmopolitan order. To this end, I provide what appears as a viable solution to Kant’s “sovereignty dilemma”; that is, the reconciliation between state sovereignty and the international enforceability of laws. I consider that a key component of the overall Kantian cosmopolitan project is the role played by the transcendental notion of an “originally united will” in its validation of constituencies. I emphasize the view that for Kant state-citizens are also, as he says, “citizens of the world” (Weltbürger) or “citizens of the earth” (Erdbürger). I argue, furthermore, that a state’s sovereignty must comply with a number of different constitutional wholes. I then proceed by confronting the Kantian notion of a general united will with the Habermasian conception of “double sovereignty.” I conclude by suggesting a fusion/synthesis between the two views, one which would require endorsing the idea of cosmopolitan constitutionalism as a meta-framework for interpreting the legitimacy of member states’ compliance with policy indications of transnational constituencies.
Association of central blood pressure with left atrial structural and functional abnormalities in hypertensive patients: Implications for atrial fibrillation prevention
Authors: Przewłocka-Kosmala Monika , Jasic-Szpak Ewelina , Rojek Aleksandra , Kabaj Maciej , Sharman James E , Kosmala Wojciech 
Published: March 2019

AimsFunctional and structural abnormalities of the left atrium have been demonstrated to be clinically and prognostically significant in a range of cardiovascular disorders, increasing the risk of atrial fibrillation. Among the potential contributors to these aberrations, central arterial factors remain insufficiently defined. Accordingly, we sought to investigate the determinants of left atrium abnormalities in hypertension, with special focus on central haemodynamics.MethodsIn this retrospective, cross-sectional study, 263 patients (age 63.8 ± 8.0 years) with uncomplicated hypertension underwent echocardiography including left atrium strain (LAS) and volume analysis, and central haemodynamics assessment using radial tonometry.ResultsPatients were grouped depending on LAS and left atrium volume index (LAVI), using externally validated cutpoints (34.1% for LAS and 34 ml/m2for LAVI). The subset with lower LAS ( n = 124) demonstrated higher central (cPP) and brachial pulse pressure (bPP), ventricular- arterial coupling, left ventricular mass index (LVMI) and LAVI, and lower global left ventricular longitudinal strain and early diastolic tissue velocity (e′). Patients with higher LAVI ( n = 119) presented higher systolic blood pressure, cPP, bPP, central augmentation pressure, LVMI and E/e′ ratio and lower LAS. In multivariable analysis, cPP was independently associated with both LAS ( β = –0.22; p = 0.002) and LAVI ( β = 0.21; p = 0.003). No independent associations with left atrium parameters were shown for bPP.ConclusionHigher cPP is detrimentally associated with left atrium structural and functional characteristics, thus providing a possible pathophysiological link with the development of substrate for atrial fibrillation. Prophylaxis of atrial fibrillation might be another argument for consideration in the treatment strategy in hypertension targeted measures addressing central blood pressure.
Immunomodulatory effects of a new whole ingredients extract from Astragalus: a combined evaluation on chemistry and pharmacology
Authors: Li Zhi Xin , Zhao Guan Ding , Xiong Wei , Linghu Ke Gang , Ma Qiu Shuo , Cheang Wai San , Yu Hua , Wang Yitao 
Published: March 2019

Abstract
Background
Water extract (WAE) and ultrafine powder (UFP) are two types of commonly used supplements in preparing various pharmaceutical products and functional foods. However, the correlations of the chemical compositions with the traditional functions between WAE and the herb itself, as well as the potential problems of safety for UFP have been more and more concerned by many doctors and customers.

Methods
In this study, a new whole ingredients extract of Astragalus (WIE) was prepared using the gradient solvent extraction method. The chemical compositions of WIE and WAE were comparatively analysed using spectrophotometric and chromatographic approaches. In addition, the in vivo immunomodulatory effect of WIE, WAE and UFP of Astragalus were comprehensively compared in cyclophosphamide (Cy)-induced immunosuppressive mice.

Results
The compositions and contents of main active ingredients (polysaccharides, saponins and flavonoids) in WIE were determined to be more abundant than those in WAE. In Cy-induced immunosuppressive mice, oral administered with low dosage of WIE (equalled to 1.0 g herb/kg/day) for 18 consecutive days significantly improved the immune-related responses (body weight, number of peripheral white blood cells, thymus and spleen indexes, splenocyte proliferations, natural killer cell activity, splenic lymphocyte subset, and serum levels of immunoglobulins G and M). The potency of three Astragalus preparations on immunomodulation was observed to be WIE ≥ UFP > WAE.

Conclusions
WIE maximally retained the chemical integrity of astragalus, and presented better therapeutic effectiveness than UFP and WAE. It can be further developed as new strategy for reasonable use of medicinal/edible herb-derived supplement (extract) for pharmaceutical and healthcare applications.
Threshold Queueing to Describe the Fundamental Diagram of Uninterrupted Traffic
Authors: Baer Niek , Boucherie Richard J. , van Ommeren Jan-Kees C. W. 
Published: March 2019

Queueing because of congestion is an important aspect of road traffic. This paper provides a novel threshold queue that models the empirical shape of the fundamental diagram. In particular, we show that our threshold queue with two service phases captures the capacity drop that is eminent in the fundamental diagram of modern traffic. We use measurements on a Danish highway to illustrate that our threshold queue is indeed capable of capturing the fundamental diagram of real-world traffic systems. We furthermore indicate the modelling power of our threshold queue via a sensitivity study showing that our model is able to capture a wide range of shapes for the fundamental diagram. The online appendix is available at https://doi.org/10.1287/trsc.2018.0850 .
New record of Grateloupia taiwanensis S.-M. Lin et H.-Y. Liang in Vietnam: Evidence of morphological observation and rbcL sequence analysis
Authors: XUAN-NGUYEN XUAN-VY , NGUYEN TRUNG-HIEU , DAO VIET-HA , LIAO LAWRENCE 
Published: March 2019

Abstract. Nguyen XV, Nguyen TH, Dao VH, Liao L. 2019. New record of Grateloupia taiwanensis S.-M. Lin et H.-Y. Liang in Vietnam: Evidence of morphological observation and rbcL sequence analysis. Biodiversitas 20: 688-695. Members of Grateloupia show highly diverse morphological traits, and this makes species classification more difficult. Samples were found growing with other marine algae nearshore, 3–5 m depth at Da Nang City. Morphological observation of vegetative and reproductive structures as well as phylogenetic analysis based on the large subunit of ribulose-1,5-bisphosphate-carboxylase-oxygenase (rbcL) sequence confirmed its identification. Phylogeny of members of Grateloupia inferred from Bayesian Inference, Maximum Likelihood, Maximum Parsimony and Neighbour Joining indicated materials collected in Vietnam compared well with known G. taiwanensis from the type locality, with very little sequence divergence. Grateloupia taiwanensis S.-M. Lin et H.-Y. Liang is therefore reported for the first time from Vietnam.
La précarité : un analyseur des chantiers dans les sciences sociales critiques
Authors: Mazières-Vaysse Adrien , Mensitieri Giulia , Tasset Cyprien 
Published: March 2019

Pour les chercheurs et les chercheuses en sciences sociales ayant le désir de produire des savoirs critiques sur les transformations contemporaines du travail et des groupes sociaux, la notion de précarité est incontournable, mais aussi problématique.
Avant de présenter les contributions de ce dossier, les auteur·e·s dressent, dans cette introduction, un bref inventaire des différents sens que peut revêtir la notion de précarité, tant dans le champ académique que dans le vaste halo des discours journalistique et politique. En effet, à la fin des années 1970, dès les premières occurrences de la notion, celle-ci se diffracte en diverses acceptions qui peuvent renvoyer à une manière de désigner les formes particulières d’emploi en lien avec le développement de nouvelles formes de pauvreté, à l’émergence d’un nouveau sujet politique dans un capitalisme en mutation ou encore aux modes de vie marginaux inspirés par le refus du travail. Objet d’une circulation internationale dans les sciences sociales et le champ militant, la notion de précarité est réappropriée dans de nombreux pays et nous revient aujourd’hui chargée de sens diversifiés, à l’origine de ce dossier. La précarité renvoie ainsi aux défaillances contemporaines de la société salariale, aux subjectivités produites par les nouveaux dispositifs de travail et, enfin, à la vulnérabilité, aux interdépendances dont procède des interrogations en termes de care et de subsistance.
IDENTIFIKASI LANGGAM DAN PERIODISASI ARSITEKTUR KOLONIAL NUSANTARA PADA BANGUNAN CAGAR BUDAYA
Authors: Sahmura Yemima , Wahyuningrum Sri Hartuti 
Published: March 2019

Pada umumnya masyarakat awam masih menganggap bahwa peninggalan sejarah dan benda-benda cagar budaya tidak memiliki arti dan manfaat bagi kehidupan langsung masyarakat. Masyarakat di sekitar lokasi tempat benda cagar budaya sadar atau tidak sadar, sebenarnya telah menikmati hasil dari keberadaan benda cagar budaya tersebut. Namun pada kenyataannya masyarakat seringkali tidak terlibat dalam upaya pelestarian benda cagar budaya tersebut. Dalam proses plestarian walaupun tidak menghasilkan karya rancangan baru, proses pelestarian terdiri dari beberapa tahap kegiatan yang saling berkesinambungan. Apabila merujuk UU RI no. 11 tahun 2010 tentang Cagar Budaya, maka terdapat tiga tahap kegiatan, yaitu : [1] perlindungan, [2] pengembangan, dan [3] pemanfaatan. Adapun tahapannya, Tahap 1 : identifikasi arsitektural objek bersejarah, Tahap 2 : pemetaan kondisi objek dan rekomendasi tindakan pelestarian. Dengan Studi Kasus Poliklinik Bethesda, Semarang, keberadaan bangunannya menjadi satu lingkungan dengan GKI Peterongan. Sekarang bangunan ini termasuk bangunan cagar budaya terdaftar sebagai rumah Tan Siang Swie. Dalam studi ini, digunakan metode deskriptif-eksploratif, analisa deskriptif kualitatif dengan pendekatan tipologi wajah arsitektur kolonial Belanda pada Klinik Bethesda Semarang. Melalui tahapan penelitian sebagai berikut: (a) observasi lapangan pada lokasi pengamatan; (b) mengidentifikasi setiap bangunan berdasarkan, kekhasan langgam/gaya, lalu menyesuaikan dengan teori yang berkaitan dengan tipologi wajah bangunan;(c) mengidentifikasi dan menganalisa detail dari setiap elemen wajah bangunan (atap, dinding, dan lantai) dan ditipologikan berdasarkan langgam/gaya bangunannya;(d) menarik kesimpulan dari analisa tersebut tentang tipologi wajah bangunan arsitektur kolonial.
Controlled Reeb dynamics — Three lectures not in Cala Gonone
Authors: Geiges Hansjörg 
Published: March 2019

AbstractThese are notes based on a mini-course at the conference RIEMain in Contact, held in Cagliari, Sardinia, in June 2018. The main theme is the connection between Reeb dynamics and topology. Topics discussed include traps for Reeb flows, plugs for Hamiltonian flows, the Weinstein conjecture, Reeb flows with finite numbers of periodic orbits, and global surfaces of section for Reeb flows. The emphasis is on methods of construction, e.g. contact cuts and lifting group actions in Boothby–Wang bundles, that might be useful for other applications in contact topology.
Contract Law Aspects of Sustainable Companies’ Certification in the Global Value Chain
Authors: Yang Juan 
Published: March 2019

Abstract
Against the background of economic globalization, sustainable development has attracted increasing attention. Given the boundary limits of jurisdiction, national legal systems are often insufficient to promote sustainability on a transnational level. Intergovernmental agreements and the private self-regulation are at play to fill the gap. As an effective instrument of the latter, sustainable companies’ certification assesses the sustainability of the company as a whole rather than evaluate particular products or services. Although private certification schemes vary greatly across different countries, they are all based on contracts. Three parties are involved in the certification regime, namely certification bodies, companies, and third parties such as customers as well as investors. There are different legal relationships between each two of them. In the case of misleading certification, the German Civil Law provides different approaches to solve disputes according to the legal relationship between the parties.
Nano-lignocellulose from recycled fibres in coatings from aqueous and ethanolic media: effect of residual lignin on wetting and offset printing quality
Authors: Imani Monireh , Ghasemian Ali , Dehghani-Firouzabadi Mohammad Reza , Afra Elyas , Gane Patrick A. C. , Rojas Orlando J. 
Published: March 2019

Abstract
Nano-lignocellulose (NLC) and lignin-free nanocellulose (nano-holocellulose, NHC) were used in paper coating to investigate their effect on coating layer quality and offset printing. The NLC was produced by microfluidisation of unbleached secondary fibres while the reference NHC was obtained from the same fibre source after lignin removal (OHEPH bleaching), following the same mechanical process. TEMPO-mediated oxidation of the fibres prior to microfluidisation was applied to increase the electrostatic charge and hydrophilicity of the nanofibrils. The coatings, displaying given surface morphology and energy, were applied on Kraft, printing-grade papers at three grammage levels. The structure of the coated and uncoated (reference) papers were accessed (SEM and AFM) and IGT printing was carried out to determine the print density, print gloss, rub-off resistance, surface energy, roughness, ink transfer, dry pick resistance, water interference and set-off. The results highlight the important effect of residual lignin or type of nanocellulose on the coating layer and the development of offset printing properties. It was observed that roughness was a key factor leading to a deterioration of the print properties, predominantly affecting the NLC coating. Considering the lower hydrophilicity of NLC, an alternative dispersion with water-alcohol mixtures is proposed. By using this dispersing medium, tailorable surface coverage, surface smoothness, ink acceptance and improved printability was achieved. We show that under these conditions and compared to NHC, NLC is equally effective as a coating layer.
User expectations of privacy in robot assisted therapy
Authors: Henkel Zachary , Baugus Kenna , Bethel Cindy L. , May David C. 
Published: March 2019

Abstract
This article describes ethical issues related to the design and use of social robots in sensitive contexts like psychological interventions and provides insights from one user design study and two controlled experiments with adults and children. User expectations regarding privacy with a therapeutic robotic dog, Therabot, gathered from a 16 participant design study are presented. Furthermore, results from 142 forensic interviews about bullying experiences conducted with children (ages 8 to 17) using three different social robots (Nao, Female RoboKind, Male RoboKind) and humans (female and male) as forensic interviewers are examined to provide insights into child beliefs about privacy and social judgment in sensitive interactions with social robots. The data collected indicates that adult participants felt a therapeutic robotic dog would be most useful for children in comparison to other age groups, and should include privacy safeguards. Data obtained from children after a forensic interview about their bullying experiences shows that they perceive social robots as providing significantly more socially protective factors than adult humans. These findings provide insight into how children perceive social robots and illustrate the need for careful considerationwhen designing social robots that will be used in sensitive contexts with vulnerable users like children.