bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conceptual framework of the nursing centre for the integration of community health nursing practice, education, and research
Authors: Juniarti Neti , Fuller Jeffrey , Zannettino Lana , Grant Julian 
Published: July 2019

AbstractAim:To develop a conceptual framework that can be used for the integration of community health nursing (CHN) practice, education, and research within a Nursing Centre (NC) model.Background:New forms of training and support are needed to equip nurses to manage the complex and costly challenges facing health care systems. The NC model provides scope to address these challenges by integrating nursing practice, education, and research. However, there is little information about how these constructs are integrated or how education is constituted within the model.Methods:This study used an embedded single case study design across three Nursing Centres (NCs) in West Java Indonesia. Semi-structured interviews and a review of relevant documents were conducted. Interview participants were recruited purposively to select stakeholders with rich information, including clients, nurses, nursing students and lecturers who have been using the NC model, as well as the head of the co-located Community Health Centres. Data was analysed using thematic analysis, pattern matching and cross-unit synthesis.Findings:Four components relevant to integration in the NC were identified, namely (1) client-centred care as the shared common ground for integration in the NC; (2) nursing education using a service learning approach; (3) the NC as a model for reviving CHN services; and (4) service improvement through research and community service activities. The service learning approach was identified as appropriate because it links services with the learning process and this serves to address the interests of both practice and education institutions. The conceptual framework identified in this study can be used to improve the functionality of NCs in Indonesia and be considered for use internationally.
‘We got more than we expected.’ Older people’s experiences of falls-prevention exercise interventions and implications for practice; a qualitative study
Authors: Lafond Natasher , Maula Asiya , Iliffe Steve , Vedhara Kavita , Audsley Sarah , Kendrick Denise , Orton Elizabeth 
Published: July 2019

Abstract

Aim:
To explore the experiences of older adults participating in strength and balance exercise programmes and understand participants’ rationale for programme uptake and completion.

Background:
Regular physical activity, specifically strength and balance exercises, has been shown to improve health and well-being and reduce the risk of falling in older adults. With the number of people living into older age increasing, understanding older people’s experiences of strength and balance programmes and what encourages their take-up and completion is extremely important. This paper reports on the qualitative experiences of older adults that previously participated in ProAct65+, a randomised controlled trial of Falls Management Exercise (FaME) programme and Otago Exercise Programme (OEP) versus usual care.

Methods:
Ten general practices in Nottinghamshire and Derbyshire, England, who participated in the ProAct65+ trial were approached to take part. Using maximum variation sampling (age, gender, falls history, fear of falling and trial arm) we recruited, via the practices, 30 people that had participated in the FaME (n = 15) or OEP (n = 15) trial arms. Participants were interviewed in their own homes. Interviews were audio-recorded, transcribed verbatim and thematically analysed.

Findings:
We identified five themes: choice of exercise programme; commitment, discipline and motivation; benchmarking, feedback and monitoring; benefits of the exercise programmes and reactions to the end of the programmes. There were four sub-themes within the benefits theme: pleasure and boredom, social interaction and isolation, physical benefits, and knowledge and understanding.
This study has outlined the experiences and identified specific barriers and facilitators to uptake and completion of falls-prevention exercises by older adults. The perspective and experiences of these participants is important if programmes are to be designed to meet the needs of the target population. Insights from this study will enable commissioners to develop and provide appropriate falls-prevention exercise programmes that encourage high uptake and programme completion.
Trade and institutions: explaining urban giants
Authors: Candau Fabien , Gbandi Tchapo 
Published: July 2019

AbstractBy analyzing the population growth at the top of the urban hierarchy, we test two hypotheses explaining the rise of mega-cities: trade and political institutions. We find that democratic institutions are the main factor behind the concentration of a nation's urban population in the main city. Contrary to the literature, we find that extractive institutions reduce the size of the biggest city.
Effect of soybean growth stage on sensitivity to sublethal rates of dicamba and 2,4-D
Authors: Scholtes Alanna B. , Sperry Benjamin P. , Reynolds Daniel B. , Irby J. Trenton , Eubank Thomas W. , Barber L. Thomas , Dodds Darrin M. 
Published: July 2019

AbstractField experiments were conducted in 2012 and 2013 across four locations for a total of 6 site-years in the midsouthern United States to determine the effect of growth stage at exposure on soybean sensitivity to sublethal rates of dicamba (8.8 g ae ha−1) and 2,4-D (140 g ae ha−1). Regression analysis revealed that soybean was most susceptible to injury from 2,4-D when exposed between 413 and 1,391 accumulated growing degree days (GDD) from planting, approximately between V1 and R2 growth stages. In terms of terminal plant height, soybean was most susceptible to 2,4-D between 448 and 1,719 GDD, or from V1 to R4. However, maximum susceptibility to 2,4-D was only between 624 and 1,001 GDD or from V3 to V5 for yield loss. As expected, soybean was sensitive to dicamba for longer spans of time, ranging from 0 to 1,162 GDD for visible injury or from emergence to R2. Likewise, soybean height was most affected when dicamba exposure occurred between 847 and 1,276 GDD or from V4 to R2. Regarding grain yield, soybean was most susceptible to dicamba between 820 and 1,339 GDD or from V4 to R2. Consequently, these data indicate that soybean response to 2,4-D and dicamba can be variable within vegetative or reproductive growth stages; therefore, specific growth stage at the time of exposure should be considered when evaluating injury from off-target movement. In addition, application of dicamba near susceptible soybean within the V4 to R2 growth stages should be avoided because this is the time of maximum susceptibility. Research regarding soybean sensitivity to 2,4-D and dicamba should focus on multiple exposure times and also avoid generalizing growth stages to vegetative or reproductive.
Fluridone and acetochlor cause unacceptable injury to pumpkin
Authors: Ferebee J. Harrison , Cahoon Charles W. , Besançon Thierry E. , Flessner Michael L. , Langston David B. , Hines Thomas E. , Blake Hunter B. , Askew M. Carter 
Published: July 2019

AbstractResidual herbicides are routinely applied to control troublesome weeds in pumpkin production. Fluridone and acetochlor, Groups 12 and 15 herbicides, respectively, provide broad-spectrum PRE weed control. Field research was conducted in Virginia and New Jersey to evaluate pumpkin tolerance and weed control to PRE herbicides. Treatments consisted of fomesafen at two rates, ethalfluralin, clomazone, halosulfuron, fluridone,S-metolachlor, acetochlor emulsifiable concentrate (EC), acetochlor microencapsulated (ME), and no herbicide. At one site, fluridone, acetochlor EC, acetochlor ME, and halosulfuron injured pumpkin 81%, 39%, 34%, and 35%, respectively, at 14 d after planting (DAP); crop injury at the second site was 40%, 8%, 19%, and 33%, respectively. Differences in injury between the two sites may have been due to the amount and timing of rainfall after herbicides were applied. Fluridone provided 91% control of ivyleaf morningglory and 100% control of common ragweed at 28 DAP. Acetochlor EC controlled redroot pigweed 100%. Pumpkin treated withS-metolachlor produced the most yield (10,764 fruits ha–1) despite broadcasting over the planted row; labeling requires a directed application to row-middles. A separate study specifically evaluated fluridone applied PRE at 42, 84, 126, 168, 252, 336, and 672 g ai ha–1. Fluridone resulted in pumpkin injury ≥95% when applied at rates of ≥168 g ai ha–1; significant yield loss was noted when the herbicide was applied at rates >42 g ai ha–1. We concluded that fluridone and acetochlor formulations are unacceptable candidates for pumpkin production.
Depletion‐Induced Seismicity at the Groningen Gas Field: Coulomb Rate‐and‐State Models Including Differential Compaction Effect
Authors: Candela Thibault , Osinga Sander , Ampuero Jean‐Paul , Wassing Brecht , Pluymaekers Maarten , Fokker Peter A. , van Wees Jan‐Diederik , de Waal Hans A. , Muntendam‐Bos Annemarie G. 
Published: July 2019

AbstractWe implement a Coulomb rate‐and‐state approach to explore the nonlinear relation between stressing rate and seismicity rate in the Groningen gas field. Coulomb stress rates are calculated, taking into account the 3‐D structural complexity of the field and including the poroelastic effect of the differential compaction due to fault offsets. The spatiotemporal evolution of the Groningen seismicity must be attributed to a combination of both (i) spatial variability in the induced stressing rate history and (ii) spatial heterogeneities in the rate‐and‐state model parameters. Focusing on two subareas of the Groningen field where the observed event rates are very contrasted even though the modeled seismicity rates are of similar magnitudes, we show that the rate‐and‐state model parameters are spatially heterogeneous. For these two subareas, the very low background seismicity rate of the Groningen gas field can explain the long delay in the seismicity response relative to the onset of reservoir depletion. The characteristic periods of stress perturbations, due to gas production fluctuations, are much shorter than the inferred intrinsic time delay of the earthquake nucleation process. In this regime the modeled seismicity rate is in phase with the stress changes. However, since the start of production and for two subareas of our analysis, the Groningen fault system is unsteady and it is gradually becoming more sensitive to the stressing rate.
Competition Between Atmospheric and Surface Parameterizations for the Control of Air‐Sea Latent Heat Fluxes in Two Single‐Column Models
Authors: Torres Olivier , Braconnot Pascale , Hourdin Frédéric , Roehrig Romain , Marti Olivier , Belamari Sophie , Lefebvre Marie‐Pierre 
Published: July 2019

AbstractA single‐column model approach conducted in the context of the Madden–Julian Oscillation through the CINDY2011/Dynamics of the Madden–Julian Oscillation field campaign is used to disentangle the respective role of the parameterizations of surface turbulent fluxes and of model atmospheric physics in controlling the surface latent heat flux. The major differences between the models used in this study occur during the suppressed phases of deep convection. They are attributed to differences in model atmospheric physics which is shown to control the near‐surface relative humidity and thereby the surface latent heat flux. In contrast, during active phases of deep convection, turbulent air‐sea flux parameterizations impact the latent heat flux through the drag coefficient and can represent two thirds of the divergence caused by the different atmospheric physics. The combined effects need to be accounted for to improve both the representation of latent heat flux and the atmospheric variables used to compute it.
Observational Evidence of Horizontal Transport‐Driven Dehydration in the TTL
Authors: Pan Laura L. , Honomichl Shown B. , Thornberry Troy , Rollins Andrew , Bui T. Paul , Pfister Leonhard , Jensen Eric E. 
Published: July 2019

AbstractA recent airborne study obtained extensive measurements in the tropical tropopause layer (TTL) over the western Pacific and provided the first opportunity to examine the relationship between water vapor and temperature in the coldest region and season of the TTL using high‐resolution in situ data. Analysis of this data set verifies key hypotheses in Lagrangian simulations of TTL transport and freeze drying. Furthermore, the observations provide a number of new insights into the transport process: In the layer below the lapse rate tropopause, vertical transport from upward motion dominates the relative humidity structure; final dehydration, dominated by large‐scale horizontal advection, occurs in the layer transacting the cold point tropopause that is often above the lapse rate tropopause, resulting in water vapor mixing ratios with corresponding frost points consistent with the coldest temperatures of the region, lower than the temperatures of the local cold points.
Observed Transport Decline at 47°N, Western Atlantic
Authors: Rhein Monika , Mertens Christian , Roessler Achim 
Published: July 2019

AbstractDespite the importance of the large‐scale Atlantic circulation for the climate system and sea level, most of the interior flow field is only known qualitatively, and neither the mean nor the variability and trends are quantified. We investigate the meridional flow field in the western Atlantic at 47°N between 44°W and 31°W, combining moored pressure inverted echo sounders and current meter moorings with lowered acoustic Doppler current profiler and Argo data. Correlations with altimetry are used to extend each of the transport time series back to 1993. At the Canadian continental margin the boundary current exports −23.1 ± 1.5 Sv to the south. Nearby, the northward flowing North Atlantic Current (NAC) imports 105.9 ± 3.4 Sv into the subpolar gyre. Constrained mainly by topography, about half of that flow recirculates in close proximity to the NAC (−58.8 ± 3.9 Sv). NAC and recirculation are significantly anticorrelated. The flow east of 37°W (−27.8 ± 2.1 Sv) has no permanent regional features and is not correlated to the NAC. The sum of the interior components (19.3 ± 3.3 Sv) shows a significant trend in the time period 1993–2018 of −0.60 Sv/year. This decline is dominated by the significant increase of the southward flow east of 37°W (−0.44 Sv/year). The trends of the other individual components are not significant, but the sum of the interior and boundary current transport is (−0.71Sv/year). The trends are most likely caused by regionally different warming.
Leaf Area Rather Than Photosynthetic Rate Determines the Response of Ecosystem Productivity to Experimental Warming in an Alpine Steppe
Authors: Li Fei , Peng Yunfeng , Zhang Dianye , Yang Guibiao , Fang Kai , Wang Guanqin , Wang Jun , Yu Jianchun , Zhou Guoying , Yang Yuanhe 
Published: July 2019

AbstractGross primary productivity (GPP) plays an important role in mediating the feedback between land carbon (C) cycle and climate warming. However, knowledge about the mechanisms regulating the response of GPP to warming is still limited. Based on a four‐year field manipulative experiment, we examined the warming effects on GPP and the potential mechanisms in a typical alpine steppe on the Tibetan Plateau. Our results revealed that elevated temperature significantly increased GPP over the study period. The warming‐induced increase in GPP was driven by the increased leaf area index, which was derived from the increase in aboveground biomass of forb. By contrast, warming had no significant effects on photosynthesis per leaf area, likely due to the offset of warming‐induced increase in leaf nitrogen concentration and decrease in soil moisture. These results demonstrate that leaf area rather than leaf photosynthetic rate determines the response of ecosystem productivity to climate warming in this alpine steppe. More studies in other ecosystems are called for to test the observed mechanisms responsible for warming effects on GPP, so as to improve predictions of terrestrial C cycle under changing environment.
Hypoxia-induced ZEB1 promotes cervical cancer progression via CCL8-dependent tumour-associated macrophage recruitment
Authors: Chen Xiao-Jing , Deng Yuan-Run , Wang Zi-Ci , Wei Wen-Fei , Zhou Chen-Fei , Zhang Yan-Mei , Yan Rui-Ming , Liang Luo-Jiao , Zhong Mei , Liang Li , Wu Sha , Wang Wei 
Published: July 2019

AbstractThe accumulation of tumour-associated macrophages (TAMs) in the hypoxic tumour microenvironment (TME) is associated with malignant progression in cancer. However, the mechanisms by which the hypoxic TME facilitates TAM infiltration are not fully understood. This study showed that high ZEB1 expression in hypoxic cervical cancer cell islets was positively correlated with CD163+ TAM accumulation. ZEB1 in hypoxic cancer cells promoted the migration of TAMs in vitro and altered the expression of multiple chemokines, especially CCL8. Mechanistically, hypoxia-induced ZEB1 activated the transcription of CCL8, which attracted macrophages via the CCR2–NF-κB pathway. Furthermore, ZEB1 and CCL8 were independent prognostic factors in cervical cancer patients based on The Cancer Genome Atlas (TCGA) data analysis. In conclusion, hypoxia-induced ZEB1 exerts unexpected functions in cancer progression by fostering a prometastatic environment through increased CCL8 secretion and TAM recruitment; thus, ZEB1 may serve as a candidate biomarker of tumour progression and provide a potential target for disrupting hypoxia-mediated TME remodelling.
An enzymatically controlled mucoadhesive system for enhancing flavour during food oral processing
Authors: Dinu Vlad , Gadon Arthur , Hurst Katherine , Lim Mui , Ayed Charfedinne , Gillis Richard B. , Adams Gary G. , Harding Stephen E. , Fisk Ian D. 
Published: July 2019

AbstractWhile a good mucoadhesive biopolymer must adhere to a mucus membrane, it must also have a good unloading ability. Here, we demonstrate that the biopolymer pullulan is partially digested by human salivary α-amylase, thus acting as a controlled release system, in which the enzyme triggers an increased release of flavour. Our oral processing simulations have confirmed an increase in the bioavailability of aroma and salt compounds as a function of oral pullulan degradation, although the release kinetics suggest a rather slow process. One of the greatest challenges in flavour science is to retain and rapidly unload the bioactive aroma and taste compounds in the oral cavity before they are ingested. By developing a cationic pullulan analogue we have, in theory, addressed the “loss through ingestion” issue by facilitating the adhesion of the modified polymer to the oral mucus, to retain more of the flavour in the oral cavity. Dimethylaminoethyl pullulan (DMAE-pullulan) was synthesised for the first time, and shown to bind submaxillary mucin, while still retaining its susceptibility to α-amylase hydrolysis. Although DMAE-pullulan is not currently food grade, we suggest that the synthesis of a sustainable food grade alternative would be a next generation mucoadhesive targeted for the oral cavity.
Open data on health-related neighbourhood features in Great Britain
Authors: Daras Konstantinos , Green Mark A. , Davies Alec , Barr Benjamin , Singleton Alex 
Published: July 2019

AbstractOur study details the creation of a series of national open source low-level geographical measures of accessibility to health-related features for Great Britain. We create 14 measures across three domains: retail environment (fast food outlets, gambling outlets, pubs/bars/nightclubs, off-licences, tobacconists), health services (General Practitioners, pharmacies, dentists, hospitals, leisure centres) and the physical environment (green space and air quality). Using the network analysis process of Routino, postcode accessibility (km) to each of these features were calculated for the whole of Great Britain. An average score for each domain was calculated and subsequently combined to form an overall Index highlighting ‘Access to Healthy Assets and Hazards’. We find the most accessible healthy areas are concentrated in the periphery of the urban cores, whilst the least accessible healthy areas are located in the urban cores and the rural areas. The open data resource is important for researchers and policy makers alike with an interest in measuring the role of spatial features on health.
Volcanically Triggered Ocean Warming Near the Antarctic Peninsula
Authors: Verona L. S. , Wainer I. , Stevenson S. 
Published: July 2019

AbstractExplosive volcanic eruptions are the largest non-anthropogenic perturbations for Earth’s climate, because of the injection of sulfate aerosols into the stratosphere. This causes significant radiation imbalances, resulting in surface cooling for most of the globe. However, despite its crucial importance for Antarctic ice sheet mass balance, the response of the Southern Ocean to eruptions has yet to be understood. After the eruption of Mt. Pinatubo in 1991, much of the Southern Ocean cooled; however, off the Antarctic Peninsula a warming of up to 0.8 °C is found in the observations. To understand the physical mechanisms associated with this counter-intuitive response, we combine observational analysis from the Mt. Pinatubo eruption with the Last Millennium Ensemble (850–1850) conducted with the Community Earth System Model. These results show not only that the observed warming off the Peninsula following the Mt. Pinatubo eruption is consistent with the forced response to low-latitude eruptions but further, that this warming is a response to roughly 16% weakening of subsurface Weddell Gyre outflow. These changes are triggered by a southward shift of the Southern Hemisphere polar westerlies (∼2°latitude). Our results suggest that warming induced by future volcanic eruptions may further enhance the vulnerability of the ice shelves off the Antarctic Peninsula.
The type VI secretion system protein AsaA in Acinetobacter baumannii is a periplasmic protein physically interacting with TssM and required for T6SS assembly
Authors: Li Lei , Wang Yi-Nuo , Jia Hong-Bing , Wang Ping , Dong Jun-Fang , Deng Juan , Lu Feng-Min , Zou Qing-Hua 
Published: July 2019

AbstractType VI secretion system (T6SS) is described as a macromolecular secretion machine that is utilized for bacterial competition. The gene clusters encoding T6SS are composed of core tss genes and tag genes. However, the clusters differ greatly in different pathogens due to the great changes accumulated during the long-term evolution. In this work, we identified a novel hypothetical periplasmic protein designated as AsaA which is encoded by the first gene of the T6SS cluster in the genus Acinetobacter. By constructing asaA mutant, we delineated its relative contributions to bacterial competition and secretion of T6SS effector Hcp. Subsequently, we studied the localization of AsaA and potential proteins that may have interactions with AsaA. Our results showed that AsaA in Acinetobacter baumannii (A. baumannii) localized in the bacterial periplasmic space. Results based on bacterial two-hybrid system and protein pull-down assays indicated that it was most likely to affect the assembly or stability of T6SS by interacting with the T6SS core protein TssM. Collectively, our findings of AsaA is most likely a key step in understanding of the T6SS functions in A. baumannii.