bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological and catalytic evaluation of Ru(II)‐p‐cymene complexes of Schiff base ligands: Impact of ligand appended moiety on photo‐induced DNA and protein cleavage, cytotoxicity and C‐H activation
Authors: Gopalakrishnan Durairaj , Srinath Santhanam , Baskar Baburaj , Bhuvanesh Nattamai S.P. , Ganeshpandian Mani 
Published: December 2018

Two organometallic Ru(II)‐p‐cymene complexes of the type [Ru(η6‐p‐cymene)(L)Cl]PF6 1 and 2, where L is N,N‐bis(4‐isopropylbenzylidene)ethane‐1,2‐diamine (bien, L1) or N,N‐bis (pyren‐2‐ylmethylene)ethane‐1,2‐diamine (bpen, L2) have been prepared and characterized well. Because of appended pyrenyl groups in coordinated bpen ligand, the complex 2 exhibits higher DNA and protein binding than complex 1 in which isopropylbenzyl groups are incorporated. Interestingly, the luminescent characteristic complex 2 is unique in displaying DNA cleavage after light activation by UVA light at 365 nm through oxygen dependent mechanism. AFM analysis attests the photo‐induced DNA fragmentation ability of complex 2. Also, the complex 2 cleaves the protein after light exposure in a non‐specific manner suggesting that it can act as a protein photo cleaving agent. In contrast to the trend of DNA and protein interaction of complexes, the complex 1 exhibits cytotoxic activity against human breast carcinoma (MCF‐7) and liver carcinoma (HepG2) with potency higher than that of complex 2 due to enhanced hydrophobicity of isopropyl groups present in p‐cymene and bien ligands. Indeed, complex 2 is inactive against MCF‐7 and HepG2 cancer cell lines even up to 200 μM concentration. The AO/EB staining assay reveals that the complex 1 is able to induce late apoptotic mode of cell death in breast cancer cells, which is further confirmed by inter‐nucleosomal DNA cleavage. Furthermore, the complexes 1 and 2 are evaluated for their catalytic activities and found to be working well for the β‐carboline directed C–H arylation to afford the desired products in good yield (40–47%).
Five‐coordinate dinuclar cobalt (II), copper (II), zinc (II) and cadmium (II) complexes with 4‐bromo‐N‐(2‐pyridinylmethylene)benzenamine: Synthesis, characterisation and methyl methacrylate polymerization
Authors: Park Suhyun , Lee Jaegyeong , Lee Hyosun , Jeong Ah Rim , Min Kil Sik , Nayab Saira 
Published: December 2018

A series of late transition metal complexes, [(bpma)Co(μ–Cl)Cl]2, [(bpma)Cu(μ–Cl)Cl]2, [(bpma)Zn(μ–Cl)Cl]2 and [(bpma)Cd(μ–Br)Br]2 (where bpma is 4‐bromo‐N‐((pyridin‐2‐yl)methylene)benzenamine) have been synthesized and structurally characterized. The X‐ray structures of dimeric complexes [(bpma)M(μ–X)X]2 (M = Co, Cu and Zn, X = Cl; M = Cd, X = Br) showed a distorted 5‐coordinate trigonal bipyramidal geometry involving two nitrogen atoms of N,N‐bidentate ligand, two bridged and one terminal halogen atoms. The complex [(bpma)Cu(μ–Cl)Cl]2 revealed the highest catalytic activity for the polymerisation of methyl methacrylate in the presence of modified methylaluminoxane with an activity of 9.14 × 104 g PMMA/mol·Cu·h at 60 °C and afforded syndiotactic poly (methylmethacrylate) (rr = 0.69).
Study the influence of sodium dodecyl sulfate on emulsification of heavy and waxy crude oils to improve their flow ability in low temperature conditions
Authors: Sharma Rohit , Deka Barasha , Mandal Arnab , Mahto Vikas 
Published: December 2018

AbstractTransportation of heavy and waxy crude oils through pipelines is a problem in many regions of the world where low temperatures are observed usually in offshore conditions due to wax and asphaltene precipitation. Transporting them as oil‐in‐water (O/W) emulsion through pipelines is one of the feasible flow assurance solutions. In this research work, O/W emulsions using anionic surfactant sodium dodecyl sulfate are prepared for two Indian crude oil samples having significant asphaltene and wax deposition potential and effect of emulsification on the flow properties of these crude oils are thoroughly analyzed. It is found that the prepared emulsions have very stable phase volume composition up to 50 days at ambient conditions, and they are thermally stable in the temperature range 20–45°C. Emulsions of heavy crude oil are found to be relatively more stable than that of waxy crude with time and temperatures. Fifty percent (v/v) is the observed optimized oil content in the prepared o/w emulsions for both the crude oils at optimum surfactant concentration that is critical micelle concentration (CMC). The prepared emulsions have viscosities as low as 0.01 Pa s and pour point as low as less than 0°C, ensuring easy flow at low temperatures, suited for pipeline transportation at subsea conditions. Interfacial tension and surface tension values of waxy crude‐water system and its o/w emulsions respectively are higher than that of heavy crude‐water system and its O/W emulsions, which indicate difficulty in waxy crude oil transportation compared with heavy crude oil.
Synthesis and characterization of nanohybrid of poly(octadecylacrylates derivatives)/montmorillonite as pour point depressants and flow improver for waxy crude oil
Authors: Al‐Sabagh A. M. , Betiha M. A. , Osman D. I. , Mahmoud Tahany 
Published: December 2018

ABSTRACTIn this paper, a novel series of nanohybrid of poly(octadecylacrylate derivatives) montmorillonite (ODA/MMT) was prepared by successfully dispersing the inorganic nanolayers of MMT‐clay on the organic polymer matrix via in situ free‐radical polymerization by different ratios. The prepared nanohybrid polymers were characterized by FTIR and Raman spectroscopy, X‐ray diffraction (XRD), HRTEM, GPC, DSC, and TGA instruments. The XRD confirmed the presence of an exfoliated/interacted clay structure in the prepared polymer. Moreover, the molecular weight of the prepared polymer nanohybrids is higher than the corresponding polymer. The results of applying the polymer as pour point depressants showed a considerable reduction from 27°C (initial pour point) to −3 °C, facilitating the process of oil flow at lower temperatures than earlier. The apparent viscosity of waxy crude oil was also decreased significantly by the addition of the (ODA/MMT) polymers, and the long‐term stability of the prepared nanohybrid polymers was superior to that of a conventional polymer. The efficiency of polymers nanohybrid in reducing the pour point of crude oil associated with improved oil flow is one of the most important processes of charge and transportation process. The mechanism of enhancement of the flow properties by the polymers nanohybrid is predicted. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47333.
An institutional analysis of the fiscal autonomy of public hospitals in Vietnam
Authors: Võ Minh Thị Hải , Löfgren Karl 
Published: December 2018

AbstractThis paper explores the fiscal autonomy of Vietnam's public hospitals through analysing the formal autonomy rules and the actual autonomy practices among selected hospitals. We argue that Vietnam's autonomisation of public hospitals underpins the increasing switch of healthcare costs from the state onto society alongside the transition from the universal and free healthcare services to a mix of state subsidy and fees‐for‐services. Utilised as a strategic instrument, hospital autonomy is reinforced in service provision, capital mobilisation, and allocation of net revenues, leaving autonomy in other dimensions increase incrementally. Consequently, Vietnam's hospital autonomisation has occasioned various revenue‐maximising practices including the provision of “patient‐requested” services, provider‐induced supply of unnecessary services, excessive use of high‐tech diagnostic equipment, inappropriate prescription of drugs, increase in patients' length of stay, and receipt of informal payments. While discerning healthcare reform in a country context, this paper expects to offer lessons to policy‐makers in developing countries, which reform their healthcare services along the market principle.
Control‐oriented fault detection of solid oxide fuel cell system unknown input on fuel supply
Authors: Wu Xiao‐long , Xu Yuan‐wu , Xue Tao , Shuai Junchao , Jiang Jianhua , Deng Zhonghua , Fu Xiaowei , Li Xi 
Published: December 2018

AbstractAs the solid oxide fuel cell (SOFC) system work environment is a high‐temperature environment for a long time, it is difficult to obtain the SOFC stack internal state change directly. When the fault occurs, it is difficult to determine where the fault occurs. Moreover, the existing literature ignores the impact of faults, which creates many problems for SOFC system control. Therefore, a state observer‐based fault detection method, which is used to detect the input flow sensor fault and the fuel input fault, is proposed. Their advantage is that they do not need data processing. To realize the fault detection, the observer is used to track the changes of SOFC stack chamber temperature. To obtain the observer estimation parameter, an approach from the actual stack structure parameters is employed to approximate the observer parameters. The results show the proposed fault detect method can judge fuel input fault type quickly and shield the disturbances signals from the sensor effectively. The proposed method also can be used to other operating points or air input fault.
Composite‐rotating consensus of multi‐agent systems with a leader and nonuniform delays
Authors: Mo Lipo , Jiang Yixuan 
Published: December 2018

AbstractThis paper focuses on the composite‐rotating consensus problem of second‐order multi‐agent systems with a leader and nonuniform time‐delays. First, a distributed control law is proposed to solve this problem. Second, by using the complex frequency domain analysis method, the maximal upper bound of time‐delays is deduced and it is proven that all agents eventually rotate around a common point while this point rotates around the origin, provided all communication time‐delays are less than the the maximal upper bound of time‐delays. Finally, simulation results are provided to demonstrate the effectiveness of the theoretical results.
Association between the pharmacokinetics of capecitabine and the plasma dihydrouracil to uracil ratio in rat: A surrogate biomarker for dihydropyrimidine dehydrogenase activity
Authors: Kobuchi Shinji , Akutagawa Mako , Ito Yukako , Sakaeda Toshiyuki 
Published: December 2018

AbstractCapecitabine is a 5‐fluorouracil (5‐FU) derivative that is used widely in the treatment of colorectal cancer. The plasma ratio of dihydrouracil (UH2) to uracil (Ura) is expected to gain relevance as an indirect‐response biomarker to estimate the activity of dihydropyrimidine dehydrogenase (DPD). The latter is a rate‐limiting enzyme in the catabolism of 5‐FU in the capecitabine‐based regimen. However, the relationship between the pharmacokinetics of capecitabine and the plasma UH2/Ura ratio is still unknown. This study evaluated the time‐course alterations of the plasma UH2/Ura ratio in rats treated with 180 mg/kg capecitabine. The molar ratio tended to increase within 1.5 h (1.85 ± 0.76 at 1.5 h after administration of capecitabine) and gradually recovered to its initial level (1.00 ± 0.46). The results of the current study suggest that the plasma UH2/Ura ratio temporarily increases following administration of capecitabine, possibly related to the DPD activity levels. The plasma UH2/Ura ratio might assist in monitoring the alteration of DPD activity levels in capecitabine treatments.
Characterization of the recombinant (R)‐ and (S)‐hydroxypropyl‐coenzyme M dehydrogenases: A case study to augment the teaching of enzyme kinetics and stereoselectivity
Authors: Clark Daniel D. 
Published: December 2018

AbstractA homologous pair of stereospecific NAD‐dependent enzymes, (R)‐ and (S)‐hydroxypropyl‐coenzyme M dehydrogenase, are part of a bacterial pathway of short‐chain alkene and epoxide metabolism. Their discovery and study, which spans multiple publications over more than a decade, is a data rich story that combines both classical and contemporary experimental biochemistry. A subset of the data for characterization of the recombinant enzymes was used as a case study to augment the teaching of enzyme kinetics and stereoselectivity in an undergraduate biochemistry course at California State University‐Chico. © 2018 International Union of Biochemistry and Molecular Biology, 47(2): 124–132, 2019.
Neuroimaging markers of global cognition in early Alzheimer's disease: A magnetic resonance imaging–electroencephalography study
Authors: Waser Markus , Benke Thomas , Dal‐Bianco Peter , Garn Heinrich , Mosbacher Jochen A. , Ransmayr Gerhard , Schmidt Reinhold , Seiler Stephan , Sorensen Helge B. D. , Jennum Poul J. 
Published: December 2018

AbstractIntroductionMagnetic resonance imaging (MRI) and electroencephalography (EEG) are a promising means to an objectified assessment of cognitive impairment in Alzheimer's disease (AD). Individually, however, these modalities tend to lack precision in both AD diagnosis and AD staging. A joint MRI–EEG approach that combines structural with functional information has the potential to overcome these limitations.Materials and MethodsThis cross‐sectional study systematically investigated the link between MRI and EEG markers and the global cognitive status in early AD. We hypothesized that the joint modalities would identify cognitive deficits with higher accuracy than the individual modalities. In a cohort of 111 AD patients, we combined MRI measures of cortical thickness and regional brain volume with EEG measures of rhythmic activity, information processing and functional coupling in a generalized multiple regression model. Machine learning classification was used to evaluate the markers’ utility in accurately separating the subjects according to their cognitive score.ResultsWe found that joint measures of temporal volume, cortical thickness, and EEG slowing were well associated with the cognitive status and explained 38.2% of ifs variation. The inclusion of the covariates age, sex, and education considerably improved the model. The joint markers separated the subjects with an accuracy of 84.7%, which was considerably higher than by using individual modalities.ConclusionsThese results suggest that including joint MRI–EEG markers may be beneficial in the diagnostic workup, thus allowing for adequate treatment. Further studies in larger populations, with a longitudinal design and validated against functional‐metabolic imaging are warranted to confirm the results.
Green indoor and outdoor environment as nature‐based solution and its role in increasing customer/employee mental health, well‐being, and loyalty
Authors: Han Heesup , Hyun Sunghyup S. 
Published: December 2018

AbstractThe present study was an empirical endeavor to explore the effect of nature‐based solutions (NBS) on the customer and employee loyalty generation process by considering the role of mental health and well‐being in the hotel industry. A quantitative approach was employed. A survey methodology with a convenience sampling technique was used to collect the data. A total of 303 responses and 301 responses for customer and employee groups, respectively, were used for data analysis. Our results of the structural analysis indicated that green indoor and outdoor environment as NBS helps customers and employees improve mental health perception, emotional well‐being, and loyalty. In addition, the prominent role of emotional well‐being in building customer loyalty and of mental health perception in building employee loyalty was uncovered. The developed conceptual frameworks for customers and employees contained a satisfactory ability in predicting loyalty. Mental health perception and emotional well‐being were mediators. Moreover, the relationship strength among study variables differed between customer and employee groups. Overall, our findings significantly increased our understanding of NBS and its critical role in the hotel industry.
Overall and disease‐specific survival of Hodgkin lymphoma survivors who subsequently developed gastrointestinal cancer
Authors: Rigter Lisanne S. , Schaapveld Michael , Janus Cecile P. M. , Krol Augustinus D. G. , van der Maazen Richard W. M. , Roesink Judith , Zijlstra Josee M. , van Imhoff Gustaaf W. , Poortmans Philip M. P. , Beijert Max , Lugtenburg Pieternella J. , Visser Otto , Snaebjornsson Petur , van Eggermond Anna M. , Aleman Berthe M. P. , van Leeuwen Flora E. , van Leerdam Monique E. 
Published: December 2018

AbstractBackgroundHodgkin lymphoma (HL) survivors have an increased risk of gastrointestinal (GI) cancer. This study aims to evaluate whether survival of patients who survived HL and developed GI cancer differs from survival of first primary GI cancer patients.MethodsOverall and cause‐specific survival of GI cancer patients in a HL survivor cohort (GI‐HL, N = 104, including esophageal, gastric, small intestinal, and colorectal cancer) was compared with survival of a first primary GI cancer patient cohort (GI‐1, N = 1025, generated by case matching based on tumor site, gender, age, and year of diagnosis). Cox proportional hazards regression was used for survival analyses. Multivariable analyses were adjusted for GI cancer stage, grade of differentiation, surgery, radiotherapy, and chemotherapy.ResultsGI‐HL cancers were diagnosed at a median age of 54 years (interquartile range 45‐60). No differences in tumor stage or frequency of surgery were found. GI‐HL patients less often received radiotherapy (8% vs 23% in GI‐1 patients, P < 0.001) and chemotherapy (28% vs 41%, P = 0.01) for their GI tumor. Compared with GI‐1 patients, overall and disease‐specific survival of GI‐HL patients was worse (univariable hazard ratio (HR) 1.30, 95% confidence interval (CI) 1.03‐1.65, P = 0.03; and HR 1.29, 95% CI 1.00‐1.67, P = 0.049, respectively; multivariable HR 1.33, 95% CI 1.05‐1.68, P = 0.02; and HR 1.33, 95% CI 1.03‐1.72, P = 0.03, respectively).ConclusionsLong‐term overall and disease‐specific survival of GI cancer in HL survivors is worse compared with first primary GI cancer patients. Differences in tumor stage, grade of differentiation, or treatment could not explain this worse survival.
Optically active crown ether‐based fluorescent sensor molecules: A mini‐review
Authors: Móczár Ildikó , Huszthy Péter 
Published: December 2018

AbstractThis mini‐review focuses on fluorescent optically active crown ethers (polymeric derivatives are not included) reported in the literature (according to our knowledge), of which enantiomeric recognition ability, and in some cases, also inorganic cation complexation properties, were investigated by the sensitive and versatile fluorescence spectroscopy. These crown ether‐based chemosensors contain various fluorophore signaling units such as binaphthyl, anthracene, pyrene, tryptophan, benzimidazole, terpyridine, acridine, phenazine, acridone, BODIPY, and another conjugated aromatic one.
Measuring Purchasing Groups Performance in the Health Care sector
Authors: Nollet Jean , Beaulieu Martin , Fabbe‐Costes Nathalie 
Published: December 2018

AbstractFor many decades, governments in Western countries have attempted to control health costs. One of the strategies used is through purchasing groups, since consolidated needs generate additional savings. Although various aspects of purchasing groups have been studied, performance measurement has been neglected; due to the lack of proper measures, tensions between the purchasing group and its members can't be addressed with more objective information. However, appropriate performance indicators are considered a prerequisite to successful collaboration. Using the in‐depth case of a Canadian purchasing group in the health care sector, this article suggests a set of performance indicators to measure results considering dimensions of the purchasing process and the interactions between the purchasing group and its members (who are also its customers). © 2018 ASAC. Published by John Wiley & Sons, Ltd.
Independent Directors, Business Risk, and the Informativeness of Accounting Earnings for Debt Contracting
Authors: Chu Ling , Mathieu Robert , Mbagwu Chima 
Published: December 2018

AbstractUsing a sample of new bank loans, we investigate the impact of business risk on the usefulness of operating income after controlling for the proportion of independent directors. Consistent with the literature, our initial analyses reveal that the presence of independent directors on a board reduces the interest rate directly and indirectly through an increase in the usefulness of operating income. However, we further provide evidence that the indirect benefit of a high proportion of independent directors is reduced when we account for the presence of business risk. This suggests that studies examining the usefulness of operating income should take into account the effect of business risk. © 2018 ASAC. Published by John Wiley & Sons, Ltd.
The brain of the tree pangolin (Manis tricuspis). V. The diencephalon and hypothalamus
Authors: Imam Aminu , Bhagwandin Adhil , Ajao Moyosore S. , Manger Paul R. 
Published: December 2018

AbstractThe diencephalon (dorsal thalamus, ventral thalamus, and epithalamus) and the hypothalamus, play central roles in the processing of the majority of neural information within the central nervous system. Given the interactions of the diencephalon and hypothalamus with virtually all portions of the central nervous system, the comparative analysis of these regions lend key insights into potential neural, evolutionary, and behavioral specializations in different species. Here, we continue our analysis of the brain of the tree pangolin by providing a comprehensive description of the organization of the diencephalon and hypothalamus using a range of standard and immunohistochemical staining methods. In general, the diencephalon and hypothalamus of the tree pangolin follow the organization typically observed across mammals. No unusual structural configurations of the ventral thalamus, epithalamus, or hypothalamus were noted. Within the dorsal thalamus, the vast majority of typically identified nuclear groups and component nuclei were observed. The visual portion of the tree pangolin dorsal thalamus appears to be organized in a manner not dissimilar to that seen in most nonprimate and noncarnivore mammals, and lacks certain features that are present in the closely related carnivores. Within the ventral medial geniculate nucleus, a modular organization, revealed with parvalbumin neuropil immunostaining, is suggestive of specialized auditory processing in the tree pangolin. In addition, a potential absence of hypothalamic cholinergic neurons is suggestive of unusual patterns of sleep. These observations are discussed in an evolutionary and functional framework regarding the phylogeny and life history of the pangolins.