bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative Mortality Rates as a Health Metric for Acute Abdominal Surgery in Low‐ and Middle‐Income Countries: A Systematic Review and Future Recommendations
Authors: Felizaire Marie‐Rachelle , Paradis Tiffany , Beckett Andrew , Fata Paola , Grushka Jeremy , Johnson Walter , Khwaja Kosar , Meara John G. , Ndayisaba Gabriel , Prakash Ipshita , Razek Tarek , Somprasong Tongmeesee , Wong Evan , Yohannan Prem , Deckelbaum Dan L. 
Published: April 2019

AbstractBackgroundApproximately 5 billion people do not have access to safe, timely, and affordable surgical and anesthesia care, with this number disproportionately affecting those from low–middle‐income countries (LMICs). Perioperative mortality rates (POMRs) have been identified by the World Health Organization as a potential health metric to monitor quality of surgical care provided. The purpose of this systematic review was to evaluate published reports of POMR and suggest recommendations for its appropriate use as a health metric.MethodsThe protocol was registered a priori with PROSPERO. A peer‐reviewed search strategy was developed adhering with the PRISMA guidelines. Relevant articles were identified through Medline, Embase, CENTRAL, CDSR, LILACS, PubMed, BIOSIS, Global Health, Africa‐Wide Information, Scopus, and Web of Science databases. Two independent reviewers performed a primary screening analysis based on titles and abstracts, followed by a full‐text screen. Studies describing POMRs of adult emergency abdominal surgeries in LMICs were included.ResultsA total of 7787 articles were screened of which 7466 were excluded based on title and abstract. Three hundred and twenty‐one articles entered full‐text screen of which 70 articles met the inclusion criteria. Variables including timing of POMR reporting, intraoperative mortality, length of hospital stay, complication rates, and disease severity score were collected. Complication rates were reported in 83% of studies and postoperative stay in 46% of studies. 40% of papers did not report the specific timing of POMR collection. 7% of papers reported on intraoperative death. Additionally, 46% of papers used a POMR timing specific to the duration of their study. Vital signs were discussed in 24% of articles, with disease severity score only mentioned in 20% of studies.ConclusionPOMR is an important health metric for quantifications of quality of care of surgical systems. Further validation and standardization are necessary to effectively use this health metric.
A 5‐Year Evaluation of the Implementation of Triple Diagnostics for Early Detection of Severe Necrotizing Soft Tissue Disease: A Single‐Center Cohort Study
Authors: Nawijn Femke , Houwert Roderick M. , van Wessem Karlijn P. J. , Simmermacher Rogier K. J. , Govaert Geertje A. M. , van Dijk Marijke R. , de Jong Mirjam B. , de Bruin Ivar G. J. , Leenen Luke P. H. , Hietbrink Falco 
Published: April 2019

AbstractBackgroundThe standardized approach with triple diagnostics (surgical exploration with visual inspection, microbiological and histological examination) has been proposed as the golden standard for early diagnosis of severe necrotizing soft tissue disease (SNSTD, or necrotizing fasciitis) in ambivalent cases. This study's primary aim was to evaluate the protocolized approach after implementation for diagnosing (early) SNSTD and relate this to clinical outcome.MethodsA cohort study analyzing a 5‐year period was performed. All patients undergoing surgical exploration (with triple diagnostics) for suspected SNSTD since implementation were prospectively identified. Demographics, laboratory results and clinical outcomes were collected and analyzed.ResultThirty‐six patients underwent surgical exploration with eight (22%) negative explorations. The overall 30‐day mortality rate was 25%, with an early, SNSTD‐related mortality rate of 11% (n = 3). Of these, one patient (4%) underwent primary amputation, but died during surgery. No significant differences between baseline characteristics were found between patients diagnosed with SNSTD in early/indistinctive or late/obvious stage. Patient diagnosed at an early stage had a significantly shorter ICU stay (2 vs. 6 days, p = 0.031). Mortality did not differ between groups; patients who died were all ASA IV patients.ConclusionDiagnosing SNSTD using the approach with triple diagnostics resulted in a low mortality rate and only a single amputation in a pre‐terminal patient in the first 5 years after implementation. All deceased patients had multiple preexisting comorbidities consisting of severe systemic diseases, such as end‐stage heart failure. Early detection proved to facilitate faster recovery with shorter ICU stay.
What Proportion of Female Sex Workers Practise anal Intercourse and How Frequently? A Systematic Review and Meta-analysis
Authors: Owen Branwen Nia , Baggaley Rebecca F. , Elmes Jocelyn , Harvey Amy , Shubber Zara , Butler Ailsa R. , Silhol Romain , Anton Peter , Shacklett Barbara , van der Straten Ariane , Boily Marie-Claude 
Published: April 2019

AbstractHIV is more efficiently acquired during receptive anal intercourse (AI) compared to vaginal intercourse (VI) and may contribute substantially to female sex workers’ (FSW) high HIV burden. We aim to determine how common and frequent AI is among FSW globally. We searched PubMed, Embase and PsycINFO for studies reporting the proportion of FSW practising AI (prevalence) and/or the number of AI acts (frequency) worldwide from 01/1980 to 10/2018. We assessed the influence of participant and study characteristics on AI prevalence (e.g. continent, study year and interview method) through sub-group analysis. Of 15,830 identified studies, 131 were included. Nearly all (N = 128) reported AI prevalence and few frequency (N = 13), over various recall periods. Most studies used face-to-face interviews (N = 111). Pooled prevalences varied little by recall period (lifetime: 15.7% 95%CI 12.2–19.3%, N = 30, I2 = 99%; past month: 16.2% 95%CI 10.8–21.6%, N = 18, I2 = 99%). The pooled proportion of FSW reporting < 100% condom use tended to be non-significantly higher during AI compared to during VI (e.g. any unprotected VI: 19.1% 95%CI 1.7–36.4, N = 5 and any unprotected AI: 46.4% 95%CI 9.1–83.6, N = 5 in the past week). Across all study participants, between 2.4 and 15.9% (N = 6) of all intercourse acts (AI and VI) were anal. Neither AI prevalence nor frequency varied substantially by any participant or study characteristics. Although varied, AI among FSW is generally common, inconsistently protected with condoms and practiced sufficiently frequently to contribute substantially to HIV acquisition in this risk group. Interventions to address barriers to condom use are needed.
In Situ Synthesis of Fluorescent Mesoporous Silica–Carbon Dot Nanohybrids Featuring Folate Receptor-Overexpressing Cancer Cell Targeting and Drug Delivery
Authors: Zhao Shuai , Sun Shan , Jiang Kai , Wang Yuhui , Liu Yu , Wu Song , Li Zhongjun , Shu Qinghai , Lin Hengwei 
Published: April 2019

Abstract
Multifunctional nanocarrier-based theranostics is supposed to overcome some key problems in cancer treatment. In this work, a novel method for the preparation of a fluorescent mesoporous silica–carbon dot nanohybrid was developed. Carbon dots (CDs), from folic acid as the raw material, were prepared in situ and anchored on the surface of amino-modified mesoporous silica nanoparticles (MSNs–NH2) via a microwave-assisted solvothermal reaction. The as-prepared nanohybrid (designated MSNs–CDs) not only exhibited strong and stable yellow emission but also preserved the unique features of MSNs (e.g., mesoporous structure, large specific surface area, and good biocompatibility), demonstrating a potential capability for fluorescence imaging-guided drug delivery. More interestingly, the MSNs–CDs nanohybrid was able to selectively target folate receptor-overexpressing cancer cells (e.g., HeLa), indicating that folic acid still retained its function even after undergoing the solvothermal reaction. Benefited by these excellent properties, the fluorescent MSNs–CDs nanohybrid can be employed as a fluorescence-guided nanocarrier for the targeted delivery of anticancer drugs (e.g., doxorubicin), thereby enhancing chemotherapeutic efficacy and reducing side effects. Our studies may provide a facile strategy for the fabrication of multifunctional MSN-based theranostic platforms, which is beneficial in the diagnosis and therapy of cancers in future.
Longitudinal associations between sexting, cyberbullying, and bullying among adolescents: Cross‐lagged panel analysis
Authors: Van Ouytsel Joris , Lu Yu , Ponnet Koen , Walrave Michel , Temple Jeff R. 
Published: April 2019

ABSTRACTIntroductionWhile adolescent sexting, or the sending of sexually explicit images, has been cross‐sectionally associated with bullying and cyberbullying, there is a lack of longitudinal studies in this area. To address this gap in the literature, we examined the longitudinal link between sexting and 1) traditional, in‐person, bullying victimization and 2) cyberbullying victimization.MethodsWe used data from a longitudinal study of ethnically diverse adolescents recruited from multiple public high schools in southeast Texas. Three waves of data were used (T2, T3 and T4). Cross‐lagged panel analysis was performed in Mplus to analyze the data.Results & ConclusionsCross‐lagged panel analyses identified autoregressive effects for all three variables, and cross‐lagged effects for cyberbullying. Sexting was associated with subsequent cyberbullying victimization across all time points, and T3 cyberbullying victimization was associated with engagement in sexting one year later. Furthermore, T2 cyberbullying victimization indirectly associated with T4 sexting via T3 cyberbullying victimization. For traditional bullying, a cross‐lagged effect was found between T3 sexting and T4 offline bullying victimization. Although T2 sexting did not directly link to subsequent traditional bullying victimization, a significant mediation effect was identified such that T3 sexting mediated the effects of T2 sexting on T4 traditional bullying victimization. Results show that sexting adolescents may be at risk for (cyber)bullying victimization and highlight the need to address both sexting and bullying in prevention and intervention efforts.
SeqSQC: A Bioconductor Package for Evaluating the Sample Quality of Next-Generation Sequencing Data
Authors: Liu Qian , Hu Qiang , Yao Song , Kwan Marilyn L. , Roh Janise M. , Zhao Hua , Ambrosone Christine B. , Kushi Lawrence H. , Liu Song , Zhu Qianqian 
Published: April 2019

Abstract
As next-generation sequencing (NGS) technology has become widely used to identify genetic causal variants for various diseases and traits, a number of packages for checking NGS data quality have sprung up in public domains. In addition to the quality of sequencing data, sample quality issues, such as gender mismatch, abnormal inbreeding coefficient, cryptic relatedness, and population outliers, can also have fundamental impact on downstream analysis. However, there is a lack of tools specialized in identifying problematic samples from NGS data, often due to the limitation of sample size and variant counts. We developed SeqSQC, a Bioconductor package, to automate and accelerate sample cleaning in NGS data of any scale. SeqSQC is designed for efficient data storage and access, and equipped with interactive plots for intuitive data visualization to expedite the identification of problematic samples. SeqSQC is available at http://bioconductor.org/packages/SeqSQC.
Analysis of mistuned forced response in an axial high-pressure compressor rig with focus on Tyler–Sofrin modes
Authors: Figaschewsky F. , Kühhorn A. , Beirow B. , Giersch T. , Schrape S. 
Published: April 2019

ABSTRACTThis paper aims at contributing to a better understanding of the effect of Tyler–Sofrin Modes (TSMs) on forced vibration responses by analysing a 4.5-stage research axial compressor rig. The first part starts with a brief review of the involved physical mechanisms and necessary prerequisites for the generation of TSMs in multistage engines. This review is supported by unsteady CFD simulations of a quasi 2D section of the studied engine. It is shown that the amplitude increasing effect due to mistuning can be further amplified by the presence of TSMs. Furthermore, the sensitivity with respect to the structural coupling of the blades and the damping as well as the shape of the expected envelope is analysed.The second part deals with the Rotor 2 blisk of the research compressor rig. The resonance of a higher blade mode with the engine order of the upstream stator is studied in two different flow conditions realised by different variable stator vane (VSV) schedules which allows to separate the influence of TSMs from the impact of mistuning. A subset of nominal system modes representation of the rotor is used to describe its mistuned vibration behaviour, and unsteady CFD simulations are used to characterise the present strength of the TSMs in the particular operating conditions. Measured maximum amplitude vs blade pattern and frequency response functions are compared against the predictions of the aeromechanical models in order to assess the strength of the TSMs as well as its influence on vibration levels.
Improved aerofoil parameterisation based on class/shape function transformation
Authors: He W. , Liu X. 
Published: April 2019

ABSTRACTA new aerofoil parameterisation method is put forward to represent an aerofoil by combining the leading edge modification class/shape function transformation (LEM CST) method and improved Hicks–Henne bump function’s method. The new class/shape function transformation (NEW CST) method has two additional basis functions comparing the original CST method. In order to confirm these two basis functions, the radial basis functions neural network (RBF) model is trained by some samples which are generated by the Latin hypercube design (LHD) method and Genetic Algorithm (GA) is proposed to achieve the basis functions of the NEW CST method. The NEW CST method has been evaluated in fitting precision of 1,545 aerofoils by comparison with the LEM CST method and the original CST method. And the improved ability of the NEW CST at the leading edge and trailing edge is verified by a series of complex aerofoil case studies within 1,545 aerofoils. The results indicate that the NEW CST method can represent the whole aerofoils and possesses the intuitive property as well as the original CST. Moreover, the number of control parameters (NCP) to parameterise aerofoils is the fewest among these three methods. Furthermore, when the NCP of the NEW CST and LEM CST is the same, the NEW CST method has the higher accuracy and smaller root mean square errors (RMSE) especially at the leading edge and trailing edge.
On-ground lateral direction control for an unswept flying-wing UAV
Authors: Ma Z. Y. , Zhu X. P. , Zhou Z. 
Published: April 2019

ABSTRACTTo solve the on-ground lateral direction control problem of the unswept flying-wing unmanned aerial vehicle (UAV) without rudder, steering system or breaking system, a control approach which uses differential propeller thrust to control the lateral direction is proposed. First, a mathematical model of the unswept flying-wing UAV on-ground moving is established. Second, based on the active disturbance rejection control (ADRC) theory, a yaw angle controller is designed by using the differential propeller thrust as the control output. Finally, a straight line trajectory tracking control law is designed by improving the vector field path following method. Experiment results show that the proposed control laws have a shorter response time, better robustness and better control precision compared with proportional integral derivative (PID) controller. The proposed controller has small computational complexity, simple parameter setting process, and uses practical measurable physical quantities, providing a reference solution for further engineering applications.
Examining Canada's return visits to the emergency department after a concussion
Authors: Morrison Laura , Taylor Rachel , Mercuri Mathew , Thompson Jennifer 
Published: April 2019

ABSTRACTObjectivesThe purpose of this study was to identify 1) the proportion of patients discharged from the emergency department (ED) with a diagnosis of concussion and return within 14 days, and 2) the characteristics that prompt a return.MethodsA health records review was conducted on adult patients with a discharge diagnosis of a concussion who accessed care through Hamilton Health Sciences EDs and Urgent Care Centre in 2016. Subsequent data were collected from those who returned to the ED within 14 days. Clinical characteristics of returners were compared to those of non-returners.ResultsOf the 389 patients included in the study, 38 (10%) returned within 14 days. Patients who sustained a concussion in a sport-related context or were referred to a specialized clinic were less likely to return (p = 0.03). Those who suffered an assault-related concussion were more likely to return (p = 0.01). Of those who did return, 42% received a CT scan with normal results, and 42% were given new discharge instructions.ConclusionsApproximately 10% of patients diagnosed with a concussion in a Canadian hospital setting returned to the ED within 14 days of their index visit. Our study suggests the opportunity to reduce this burden to both the healthcare system and the patient through careful discharge instructions outlining anticipated symptoms following a concussion (specifically, headache) or referral to a concussion clinic.
Linking leader power use and performance: The mediating role of follower satisfaction and commitment
Authors: Reiley Peter J. , Jacobs Rick R. 
Published: April 2019

AbstractThis study examined the intermediate role job satisfaction and organizational commitment play between leaders' perceived use of power and followers' performance. Based on a sample of 365 cadets at the U.S. Air Force Academy, this study found followers' job satisfaction and commitment mediated the positive relationships between their leaders' use of expert, referent, and reward power and the followers' organizational citizenship behavior. Further, while the use of legitimate or coercive power were both related negatively to followers' in-role job performance, these relationships were not mediated by the followers' job satisfaction or organizational commitment. This study then discusses the practical implications of these findings, highlights its theoretical contributions toward understanding power's direct and indirect relationships with performance in the leadership dynamic, and recommends future research avenues to leverage and build upon these findings.
Smoking cessation and the general practice pharmacist
Authors: Deeks Louise S , Kosari Sam , Develin Anne , Peterson Gregory M. , Naunton Mark 
Published: April 2019

AbstractIntroductionRoles for pharmacists in general practice are developing in Australia. It is known that pharmacists can provide effective smoking cessation services in other settings but evidence in general practice is lacking.AimTo determine whether a pharmacist can provide effective smoking cessation services within general practice.MethodData from smoking cessation consultations were obtained for 66 consecutive patients seen by one practice pharmacist. The pharmacist tailored interventions to the individual. Medication was offered in collaboration with community pharmacists and general practitioners. Quit coaching, based on motivational interviewing, was conducted. Smoking status was ascertained at least 6 months after the intended quit date and verified by a carbon monoxide breath test where possible.ResultsThe patients’ median age was 43 years (range 19–74 years); 42 were females (64%). At baseline, the median (i) number of pack years smoked was 20 (range: 1–75); (ii) Fagerstrom Test of dependence score was 6 (1–10); and (iii) number of previous quit attempts was 3 (0–10). Follow-up after at least 6 months determined a self-reported point prevalence abstinence rate of 30% (20/66). Of all patients who reported to be abstinent, 65% (13/20) were tested for carbon monoxide breath levels and were all below 7 ppm. The biochemically verified smoking abstinence rate was therefore 20% overall (13/66). Successful quit attempts were associated with varenicline recommendation (69% v 25%), increased median number of practice pharmacist consultations (4 v 2 per patient) and mental health diagnosis (85% v 51%).ConclusionOur observed abstinence rate was comparable or better than those obtained by practice nurses, community pharmacists and outpatient pharmacists, indicating the general practice pharmacist provided an effective smoking cessation intervention. A larger randomised trial is warranted.
New excavations at the late Pleistocene site of Chinchihuapi I, Chile
Authors: Dillehay Tom D. , Ocampo Carlos , Saavedra Jose , Pino Mario , Scott-Cummings Linda , Kovácik Peter , Silva Claudia , Alvar Rodrigo 
Published: April 2019

AbstractThis paper presents new excavation data on the Chinchihuapi I (CH-I) locality within the Monte Verde site complex, located along Chinchihuapi Creek in the cool, temperate Valdivian rain forest of south-central Chile. The 2017 and 2018 archaeological excavations carried out in this open-air locality reveal further that CH-I is an intermittently occupied site dating from the Early Holocene (~10,000 cal yr BP) to the late Pleistocene (at least ~14,500 cal yr BP) and probably earlier. A new series of radiocarbon dates refines the chronology of human use of the site during this period. In this paper, we describe the archaeological and stratigraphic contexts of the recent excavations and analyze the recovered artifact assemblages. A fragmented Monte Verde II point type on an exotic quartz newly recovered from excavations at CH-I indicates that this biface design existed in at least two areas of the wider site complex ~14,500 cal yr BP. In addition, associated with the early Holocene component at CH-I are later Paijan-like points recovered with lithic tools and debris and other materials. We discuss the geographic distribution of diagnostic artifacts from the site and their probable relationship to other early sites in South America.
Prevalence of dysphagia in patients with muscle tension dysphonia
Authors: Hamdan A-L , Khalifee E , Jaffal H , Ghanem A , El Hage A 
Published: April 2019

AbstractBackgroundIt is hypothesised that patients with muscle tension dysphonia have a high prevalence of dysphagia in comparison to normative values reported in the literature.MethodsThis prospective study included 44 subjects diagnosed with muscle tension dysphonia, based on symptoms and laryngoscopic findings, and 25 control subjects with no history of dysphonia and normal laryngeal examination findings. Demographic data included age, gender and smoking history. The aetiology of muscle tension dysphonia was classified as primary or secondary. Evaluation involved the Eating Assessment Tool (‘EAT-10’) questionnaire.ResultsPatients’ mean age was 45.93 ± 14.95 years, with a female to male ratio of 1.2:1. Fourteen patients had primary muscle tension dysphonia, while 30 had secondary muscle tension dysphonia. Among patients with secondary muscle tension dysphonia, Reinke's oedema was the most common aetiology. There was a significant difference in the prevalence of dysphagia between the study group and the control group (40.9 per cent vs 8 per cent respectively, p &lt; 0.05).ConclusionThis study demonstrates a higher prevalence of dysphagia in patients with the presenting symptom of dysphonia and diagnosed with muscle tension dysphonia in comparison to subjects with no dysphonia.