bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biometrics in the Context of Personal Data and Genetic Information: Legal Issues
Authors: Rassolov I. M. , Chubukova S. G. , Mikurova I. V. 
Published: February 2019

In modern society, methods of identification of persons on the basis of their physical, biological or behavioral characteristics are actively developing. European countries are in the process of developing a holistic doctrine on biometric control and are clarifying their position on situations where biometric data are used by individuals.From the position of information law, the paper presents a new author’s approach to the problem of processing biometric data and genetic information. The division of biometrics into “trace” and “non-trace” is losing its meaning. A new classification of biometrics into digital and analog is proposed.Biometric access control should not become a routine phenomenon in the framework of the organization of the company and without any reason to replace other existing types of control. The interested person can be entrusted with the storage of their own biometric data to reduce the risks of leakage and the consequences of exposure to them. Biometric data must be stored on the company’s servers in encrypted form, which makes it impossible to use them without the consent of the person concerned.Biometric data should be protected by a special legal regime. The analysis of the European and Russian legislation made it possible to draw the following conclusions: biometric data is a special type of personal data, a special legal regime and regulation should be established; digital biometrics needs special legal regulation, since it is the most vulnerable type; genetic information does not fully correspond to the concept of personal data, as it can relate to an unlimited number of persons. This determines the need to develop a special law “on genetic information”.
Impact of the Pre-operative Chemoradiation Therapy on Complications in Patients with Locally Advanced Esophageal Cancer
Authors: Shogenov M. S. , Davydov M. M. , Allakhverdiyev A. K. , Filatov A. A. , Chekini A. K. , Akhmedov P. I. , Serebryanskaya M. V. , Dadyev I. A. , Grigorenko V. A. , Nazliyev P. B. , Malikhova O. A. , Tryakin A. A. 
Published: February 2019

The aim of this study was to evaluate the effect of the chemoradiation therapy on the incidence of postoperative complications and mortality rate in patients with locally advanced tumors of the thoracic esophagus.The study included men and women over 18 with histologically verified squamous cell carcinoma of the thoracic esophagus with TNM stage cT3-4aN0-3M0. Patients were divided into two groups: patients in a main group (n=26) received a complex treatment, patients in a second group (n=30) undergoing only surgical treatment.The first stage of treatment was performed for all 26 patients and included 2 courses of preoperative chemotherapy, followed by a chemoradiation therapy with a 44–46 Gy with weekly injections of chemotherapy. Surgical procedure (R0) was performed for 24 patients (92.3 %) in the main group and for 26 (86.6 %) in a second group.Therapeutic complications were developed in 17 (65 %) patients in a first group, while in a second group this rate was in 18 (60 %) patients from 30. The incidence of surgical complications was slightly higher in a group of patients received a complex treatment –7 (26.92 %) patients. In the surgical group such complications was noted in 6 (20 %) patients. The only death in an early postoperative period was in 1 (3.84 %) patient from the main group. The cause was sepsis and the development of multiple organic failure. There were no lethal outcomes in a surgical group.Estimating the incidence of complications, it should be noted that the use of chemoradiation therapy in the neoadjuvant regimen does not significantly affect the course of the postoperative period. The mortality rate was slightly higher in in the group of patients received complex treatment. At the same time, improvement of the ostoperative period and a reduction of mortality rate in group ofpatients undergoing complex treatment is possible due to optimization of preoperative preparation, postoperative management and competent selection of patients.
Multiparametric ultrasound diagnosis of metastatic and lymphoproliferative changes in lymph nodes in primary-multiple malignant tumors, including breast cancer and lymphoma
Authors: Kovaleva E. V. , Danzanova T. Yu. , Sinyukova G. T. , Lepedatu P. I. , Gudilina E. A. , Kolyadina I. V. , Zeynalova P. A. , Semenova A. A. 
Published: February 2019

In this article, based on two clinical examples, the possibilities of multiparametric ultrasound in the differential diagnosis of metastatic and lymphoproliferative changes in lymph nodes in primary-multiple malignant tumors, including breast cancer and lym - phoma, are evaluated. Multiparameteric ultrasound includes B-mode, color and energy Doppler imaging, strain elastography, shear wave elastography and contrast-enhanced ultrasound (CEUS). Standardization and reproducibility of these ultrasound techniques will allow to objectify the study, obtaining specific indicators of shear wave velocity in the zones of interest and specific signs of contrast enhancement, which can be used as impor tant differential diagnostic tool in oncology.
Modelo de seguimiento a proyectos como herramienta en la interventoría de contratos
Authors: Prieto Cárdenas César Augusto 
Published: February 2019

Rev.esc.adm.neg
El problema más común que enfrentan las administraciones públicas, es la ausencia de un método eficaz y sistemático para realizar el seguimiento a través de mediciones de avance de la gestión y evaluar los resultados de aquellas iniciativas de inversión que están orientadas a financiar de manera directa y de forma recurrente la operación de las entidades.
En este contexto, el presente trabajo pretende desarrollar un método cuantitativo que permita realizar la medición del logro del objeto contractual a través del avance de las obligaciones del contratista acordadas para la entrega del bien o servicio.
La propuesta metodológica que se presenta a continuación busca implementar el Modelo de Seguimiento a la ejecución del avance del objeto contractual -MOSAC- en sus dos niveles: estratégico —componentes— y operativo —obligaciones—.
En este sentido, el Modelo de Seguimiento MOSAC se convierte en un instrumento de implementación a la ejecución ef Rev.esc.adm.negectiva de los contratos que lleve a cabo la Administración pública.
Potencial competitivo de tres mipymes del sector agroindustrial de la provincia de Ubaté, Colombia
Authors: Melo Perdomo Sandra Milena , Orrego Crescencio , Gómez Roldán Ignacio , Gil Palacios Johanna Andrea 
Published: February 2019

Rev.esc.adm.neg
El presente trabajo tiene como objetivo principal estudiar el potencial competitivo de tres empresas del sector agroindustrial de la Provincia de Ubaté, a través de una herramienta que permite hacer este análisis desde una perspectiva endógena. Se describe primero la fundamentación teórica y posteriormente se describe paso a paso el método, cuyo uso fue motivado por la posibilidad de disminuir las dificultades actuales para medir la competitividad de una empresa: necesidad de niveles altos de información de los competidores y la multiplicidad de componentes a calificar en los rankings actuales. Desde una metodología analítico-descriptiva se presentan resultados, cuyo origen requirió análisis cualitativo y cuantitativo, y las conclusiones comparadas validan el modelo en el contexto estudiado y su nivel de replicabilidad a otras empresas del sector.
Proyectos de desarrollo de proveedores que usan Six Sigma: un análisis de caso en Schneider Electric Colombia S.A
Authors: Zuluaga Muñoz William 
Published: February 2019

Rev.esc.adm.neg
Los programas de desarrollo de proveedores (SDP) se componen de proyectos para incrementar el rendimiento de los mismos y aunque son un problema clave en la literatura de la cadena de suministro, no son frecuentes los estudios de caso que documenten lecciones aprendidas al respecto. Se busca entonces socializar brevemente los pasos de la metodología DMAIC en el caso real de un proyecto de desarrollo de proveedores (PDP) en una empresa de manufactura. Para ello se abordó la metodología Six Sigma / DMAIC desde a) el acta de constitución del proyecto, b) Los resultados obtenidos en cada fase DMAIC tras la aplicación de las técnicas afines, c) Las mejoras implementadas y d) La métrica de control del proceso. Por último, se concluye que el proyecto aplicado en Schneider Electric de Colombia S.A. (SEC) se puede catalogar como un proyecto de desarrollo de proveedores y se sugiere que la no inclusión de algunas actividades en su planificación pudo incidir en el no cumplimiento del objetivo definido por la gerencia.
The Level of corporate social responsibility in Mexican franchises
Authors: Flores Villanueva Cesario Armando , Gaytán Ramírez María del Carmen 
Published: February 2019

Rev.esc.adm.neg
This research evaluates the level of corporate social responsibility activities by the application of 26 indicators grouped according to the following dimensions: environment, society, corporate management and products and services. Beginning with the analysis of 401 websites of franchises that are currently operating in Mexico, 22.9% really communicates corporate social responsibility activities. This hypothesis combines the theory based on resources, the theory of stakeholders and the theory of agency. Its regression outcomes indicate that the franchise age and the percentage of franchise chain units influence the level of corporate social responsibility activities in a negative way; meanwhile the size and the entry quote influence their level in a positive way.
Creación de valor compartido: estado y contribuciones a la sostenibilidad corporativa
Authors: Melamed-Varela Enrique , Blanco-Ariza Ana Beatriz , Rodríguez-Calderón Gisella 
Published: February 2019

Rev.esc.adm.neg
Para la gestión de organizaciones no debe ser indiferente la contribución de las organizaciones al desarrollo sostenible del entorno, pues debe coexistir una generación de valor para la sociedad y la empresa, por ello este documento enmarca su propósito en establecer el estado actual del concepto de creación de valor compartido en la narrativa académica y científica, por lo cual se ha realizado una revisión de literatura y el correspondiente análisis bibliométrico del concepto, en documentos con indexación internacional, determinando consideraciones clave que diferencian su accionar con la responsabilidad social y determinan su fundamento desde la sostenibilidad corporativa.
Análisis del liderazgo social de las pymes de Santa Marta —Colombia—, para el post-acuerdo desde el enfoque de la Responsabilidad Social Empresarial
Authors: Jiménez Sierra Devinso , Rincón Acevedo Alejandrina , Pérez Suescún Leonardo 
Published: February 2019

Rev.esc.adm.neg
El artículo presenta un análisis correlacional entre los estilos de liderazgo propuestos por Kurt Lewin y la disposición para asumir acciones de Responsabilidad Social Empresarial en pymes de la ciudad de Santa Marta en el contexto del post-acuerdo.Como objetivo se estableció analizar el liderazgo social de las pymes para el post-acuerdo desde la perspectiva de la RSE, para ello en una primera fase, se aplicó el índice de liderazgo de las pymes por medio del test de liderazgo de Kurt Lewin estimando las variables género, cualificación y tamaño de las empresas. En una segunda fase se determinó el índice de disposición de las pymes para participar en procesos vinculados al post-acuerdo teniendo en cuenta aspectos como construcción para paz, inclusión, desarrollo económico y el reúso de insumos propios para la operación de las organizaciones. En una tercera fase se prueba la correlación entre el liderazgo y la disposición para participar en procesos vinculados a post-acuerdo.
Diagnóstico para la implementación de las herramientas Lean Manufacturing, desde la estrategia de operaciones en algunas empresas del sector textil confección de Colombia: reporte de caso
Authors: González Gaitán Henry Helí , Marulanda Grisales Natalia , Echeverry Correa Francisco Javier 
Published: February 2019

Rev.esc.adm.neg
La filosofía de Lean Manufacturing hace parte de las metodologías de mejoramiento continuo, que facilitan la gestión sistémica de las organizaciones. Teniendo esto en cuenta, se formula como propósito de este artículo presentar el diagnóstico realizado en torno a la implementación de las herramientas Lean Manufacturing desde la estrategia de operaciones, dando a conocer de esta manera los factores relevantes que intervienen en la implementación de las mismas, todo lo anterior a partir de los hallazgos de la investigación realizada en algunas empresas del sector textil confecciones de la sub-región del Valle de Aburrá, del departamento de Antioquia, en Colombia.Esta investigación tuvo un carácter mixto, enfocado en un estudio de caso, para el que se utilizó una muestra por conveniencia y un cuestionario de preguntas estructuradas, el cual permitió identificar las variables que favorecen la mejorar la productividad y rentabilidad de las empresas en el largo plazo.
Effectiveness of the serious game ‘You &amp; I’ on the mentalizing abilities of adults with mild to borderline intellectual disabilities: a parallel superiority randomized controlled trial
Authors: Derks S.D.M. , Wijngaarden S. van , Wouda M. , Schuengel C. , Sterkenburg P.S. 
Published: February 2019

Abstract
Background: Persons with mild to borderline intellectual disabilities generally show dysfunctions in mentalization, including impairments in stress regulation, resulting in problematic social relationships and personal distress. Inteention programs can, however, improve mentalizing abilities. The aim of this study is to examine the effectiveness of the serious game ‘You & I’ on mentalizing abilities and stress regulation in adults with mild to borderline intellectual disabilities.
Methods: A two-arm, parallel, superiority randomized controlled trial will be used with 172 adults with mild to borderline intellectual disabilities. Participants will be randomly assigned to either the experimental group to play the serious game ‘You & I’ or a waitlist control group. Participants will be assessed at baseline, post-intervention (5 weeks after baseline), and follow-up (6 to 8 weeks after post-intervention). They also will fill in questionnaires measuring personal factors, personal development, and personal well-being, social validity, and autism spectrum quotient (demographic variables), mentalizing abilities (primary outcome measure), and stress regulation (secondary outcome measure).
Discussion: The serious game ‘You & I’ aims to improve mentalizing abilities in adults with mild to borderline intellectual disabilities, which is expected to lead to improved regulation of stress in social relationships. The study’s unique feature is the use of a serious game to improve mentalizing abilities, which is expected to provide insight into the game’s effectiveness for adults with mild to borderline intellectual disabilities. If the intervention is effective, the serious game can be implemented on a broad scale in Dutch care organizations for people with intellectual disabilities as an effective tool to improve mentalizing abilities. It will be made available online, free of charge.
Trial Registration: Nederlands Trial Register NTR7418 (registered 2 August 2018).
Keywords: Mentalization, stress regulation, intellectual disability, serious game.
The Diagnostic Accuracy of an Intelligent and Automated Fundus Disease Image Assessment System with Lesion Quantitative Function (SmartEye) in Diabetic Patients
Authors: XU Yi , WANG Yongyi , LIU Bin , TANG Lin , LV Liangqing , LU Lina , ZOU Haidong 
Published: February 2019

Abstract
Background: With the diabetes mellitus (DM) prevalence increasing annually, the human grading of retinal images to evaluate DR has posed a substantial burden worldwide. SmartEye is a recently developed fundus image processing and analysis system with lesion quantification function for DR screening. It is sensitive to the lesion area and can automatically identify the lesion position and size. We reported the diabetic retinopathy (DR) grading results of SmartEye versus ophthalmologists in analyzing images captured with non-mydriatic fundus cameras in community healthcare centers, as well as DR lesion quantitative analysis results on different disease stages.
Methods: This is a cross-sectional study. All the fundus images were collected from the Shanghai Diabetic Eye Study in Diabetics (SDES) program from Apr 2016 to Aug 2017. 19904 fundus images were acquired from 6013 diabetic patients. The grading results of ophthalmologists and SmartEye are compared. Lesion quantification of several images at different DR stages is also presented.
Results: The sensitivity for diagnosing no DR, mild NPDR (non-proliferative diabetic retinopathy), moderate NPDR, severe NPDR, PDR (proliferative diabetic retinopathy) are 86.19%, 83.18%, 88.64%, 89.59%, and 85.02%. The specificity are 63.07%, 70.96%, 64.16%, 70.38%, and 74.79%, respectively. The AUC are PDR, 0.80 (0.79, 0.81); severe NPDR, 0.80 (0.79, 0.80); moderate NPDR, 0.77 (0.76, 0.77); and mild NPDR, 0.78 (0.77, 0.79). Lesion quantification results showed that the total hemorrhage area, maximum hemorrhage area, total exudation area, and maximum exudation area increase with DR severity.
Conclusions: SmartEye has a high diagnostic accuracy in DR screening program using non-mydriatic fundus cameras. SmartEye quantitative analysis may be an innovative and promising method of DR diagnosis and grading.
Keywords: Diabetic retinopathy, Screening, Digital imaging processing, Lesion quantification, Epidemiology.
Tranexamic acid for acute gastrointestinal bleeding (The HALT-IT trial): Statistical analysis plan for an international, randomised, double blind, placebo-controlled trial
Authors: Brenner Amy Charlotte , Afolabi Adefemi , Ahmad Syed Masroor , Arribas Monica , Chaudhri Rizwana , Coats Timothy , Cuzick Jack , Gilmore Ian , Hawkey Christopher , Jairath Vipul , Javaid Kiran , Kayani Aasia , Mutti Muttiullah , Nadeem Muhammad Arif , Shakur-Still Haleema , Stanworth Simon , Veitch Andrew , Roberts Ian 
Published: February 2019

Abstract
Background: Acute gastrointestinal (GI) bleeding is an important cause of mortality worldwide. Bleeding can occur from the upper or lower GI tract, with upper GI bleeding accounting for most cases. The main causes include peptic ulcer / erosive mucosal disease, oesophageal varices and malignancy. The case fatality rate is around 10% for upper GI bleeding and 3% for lower GI bleeding. Rebleeding affects 5-40% of patients and is associated with a four-fold increased risk of death. Tranexamic acid (TXA) decreases bleeding and the need for blood transfusion in surgery and reduces death due to bleeding in patients with trauma and postpartum haemorrhage. It reduces bleeding by inhibiting the breakdown of fibrin clots by plasmin. Due to the methodological weaknesses and small size of the existing trials, the effectiveness and safety of TXA in GI bleeding is uncertain. The HALT-IT trial aims to provide reliable evidence about the effects of TXA in acute upper and lower GI bleeding.
Methods: The HALT-IT trial is an international, randomised, double blind, placebo-controlled trial of tranexamic acid in 12,000 adults (increased from 8,000) with acute upper or lower GI bleeding. Eligible patients are randomly allocated to receive tranexamic acid (1g loading dose followed by 3g maintenance dose over 24 hours) or matching placebo. The main analysis will compare those randomised to tranexamic acid with those randomised to placebo on an intention-to-treat basis, presenting the results as effect estimates (relative and absolute risks) and confidence intervals. The primary outcome is death due to bleeding within 5 days of randomisation and secondary outcomes are rebleeding, all-cause and cause-specific mortality, thromboembolic events, complications, endoscopic, radiological and surgical interventions, blood transfusion requirements, disability (defined by a measure of patient’s self-care capacity) and number of days spent in intensive care or high dependency units. Subgroup analyses for the primary outcome will consider time to treatment, location of bleeding, cause of bleed and clinical Rockall score.
Discussion: We present the statistical analysis of the HALT-IT trial. This plan was prepared and submitted for publication before the treatment allocation was un-blinded.
Trial Registration: Current Controlled Trials ISRCTN11225767 (3/07/2012); Clinicaltrials.gov NCT01658124 (26/07/2012).
Keywords: Gastrointestinal haemorrhage, tranexamic acid, clinical trial, statistical analysis.
WITHDRAWN: Cost-effectiveness of total laparoscopic hysterectomy and non-descent vaginal hysterectomy versus total abdominal hysterectomy: a multi-centre randomized controlled trial
Authors: Ekanayake Chanil Deshan , Pathmeswaran Arunasalam , Kularatna Sanjeewa , Herath Rasika , Wijesinghe Prasantha 
Published: February 2019

Abstract
Background: Hysterectomy is the most common major surgical procedure in gynaecology. The methods in mainstream practice are; total abdominal hysterectomy (TAH), non-descent vaginal hysterectomy (NDVH) and total laparoscopic hysterectomy (TLH). Most patients requiring hysterectomy for benign gynaecological conditions can be operated using one of these methods. The aim of this study was to study cost-effectiveness of NDVH, TLH and TAH in a low resource setting.
Methods: A pragmatic multi-centre three arm (parallel groups) RCT was done in the professorial gynaecology unit of the North Colombo Teaching Hospital, Ragama and the gynaecology unit of the District General Hospital, Mannar, Sri Lanka. Participants were patients requiring hysterectomy for non-malignant uterine causes. Exclusion criteria were uterus>14 weeks, previous pelvic surgery, medical illnesses which contraindicate laparoscopic surgery, and those requiring incontinence surgery or pelvic floor surgery. The main outcome measures were time to recover and cost. The willingness-to-pay (WTP) threshold was set at USD 1000.
Results: There was no significant difference in median time to recover (inter quartile range) among TAH, NDVH and TLH which was 35 (30-45), 32 (24.5-60) and 30 (25.5-45) days respectively (p=0.37). The difference in area under the curve for quality adjusted life years (QALYs) was 1.33 and 5.21 for NDVH and TLH compared to TAH. The direct cost (median, interquartile range) of a TLH [USD 349 (322-378)] was significantly higher compared to TAH [USD 289 (264-307)] and NDVH [USD 279 (255-305)]. The incremental cost-effectiveness ratio (ICER) for TLH was USD 12/day whereas NDVH showed a net benefit as both costs and median effect were superior to TAH. The incremental cost utility ratio (ICUR) for TLH and NDVH were 12 and 38 USD/QALY. The ICUR for TLH compared to NDVH was USD 3/per QALY. The net monetary benefit (NMB) was USD 4897 and USD 1264 for TLH and NDVH respectively.
Conclusion: Despite there being only a marginal difference among the three routes when considering time to recover, a cost-effectiveness approach using ICER, ICUR and NMB shows that alternate routes, NDVH and TLH to be superior to the conventional TAH.
Trial Registration: Sri Lanka clinical trials registry, SLCTR/2016/020 and the International Clinical Trials Registry Platform, U1111-1194-8422, on 26 July 2016. Available from: http://slctr.lk/trials/515.
Keywords: Non-descent vaginal hysterectomy, total laparoscopic hysterectomy, total abdominal hysterectomy, cost-effectiveness, randomized controlled trial.