bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Performance MXene Hydrogel for Self‐Propelled Marangoni Swimmers and Water‐Enabled Electricity Generator
Authors: Zhou Jiayi , Zhang Yan , Zhang Ming , Yang Dongye , Huang Wenwei , Zheng Ao , Cao Lingyan 
Published: November 2024

AbstractDeveloping multifunctional materials that integrate self‐propulsion and self‐power generation is a significant challenge. This study introduces a high‐performance MXene‐chitosan composite hydrogel (CM) that successfully combines these functionalities. Utilizing Schiff base bond and hydrogen bond interactions, the CM hydrogel, composed of chitosan, vanillin, and MXene, achieves exceptional self‐propulsion on water driven by Marangoni forces. The hydrogel demonstrates rapid movement, extended operation, and controllable trajectories. Notably, the CM hydrogel also exhibits superior degradability, recyclability, and repeatability. Furthermore, the nano‐confined channels within the hydrogel play a crucial role in enhancing its water‐enabled electricity generation (WEG) performance. By efficiently adsorbing water molecules and selectively transporting cations through these channels, the hydrogel can generate electricity from water molecules and cations more efficiently. As a result, the CM‐WEG achieves a stable open‐circuit voltage of up to 0.83 V and a short‐circuit current of 0.107 mA on seawater, with further improvements in K2CO3‐containing water, reaching 1.26 V and 0.922 mA. Leveraging its unique combination of self‐propulsion and WEG functionalities, the CM hydrogel is successfully used for cargo delivery while simultaneously powering electronic devices. This research represents a significant step toward the development of self‐powered, autonomous soft robotics, opening new research directions in the field.
Biomimetic Targeted Co‐Delivery System Engineered from Genomic Insights for Precision Treatment of Osteosarcoma
Authors: Luo Tianqi , Fan Zhijin , Zeng Anyu , Wang Anqi , Pan Yuanwei , Xu Yanyang , Chen Hongmin , Chen Weiqing , Nie Dingmeng , Lin Jiaming , Huang Anfei , Gong Ming , Huang Yufeng , Ding Yun , Zhu Xiaojun , Rao Lang , Wang Jin 
Published: November 2024

AbstractThe high heterogeneity and severe side effects of chemotherapy are major factors contributing to the failure of osteosarcoma treatment. Herein, a comprehensive genomic analysis is conducted, and identified two prominent characteristics of osteosarcoma: significant cyclin‐dependent kinases 4 (CDK4) amplification and homologous recombination repair deficiency. Based on these findings, a co‐delivery system loaded with CDK4/6 inhibitors and poly ADP‐ribose polymerase (PARP) inhibitors is designed. By employing metal–organic frameworks (MOFs) as carriers, issue of drug insolubility is effectively addressed, while also enabling controlled release in response to the tumor microenvironment. To enhance targeting capability and biocompatibility, the MOFs are further coated with a bio‐membrane targeting B7H3. This targeted biomimetic co‐delivery system possesses several key features: 1) it can precisely target osteosarcoma with high B7H3 expression; 2) the combination of CDK4/6 inhibitors and PARP inhibitors exhibits synergistic effects, significantly impairing tumor's DNA repair capacity; and 3) the system has the potential for combination with photodynamic therapy, amplifying DNA repair defects to maximize tumor cell eradication. Furthermore, it is observed that this co‐delivery system can activate immune microenvironment, increasing CD8+ T cell infiltration and converting osteosarcoma from an immune‐cold to an immune‐hot tumor. In summary, the co‐delivery system is an effective therapeutic strategy and holds promise as a novel approach for osteosarcoma treatment.
Preparation of Multifunctional Nano‐Protectants for High‐Efficiency Green Control of Anthracnose
Authors: Yin Jiaming , Zhao Jiajia , Wang Zeng , Fang Zhen , Guo Huiming , Cheng Hongmei , Li Jie , Shen Jie , Yin Meizhen , Su Xiaofeng , Yan Shuo 
Published: November 2024

AbstractNanomaterials cannot only act as active ingredients (AIs), but also adjuvants to encapsulate or attach AIs to improve their fungicidal activity. Herein, a hydrophilic and lipophilic diblock polymer (HLDP) is designed and synthesized to prepare a series of HLDP nano‐protectants to explore the best HLDP nano‐protectant for anthracnose management. These results demonstrate that the HLDP‐CS nano‐protectant displays the best control effects on mango anthracnose via the direct pathogen inhibition and amplified plant immune responses. The HLDP can be spontaneously conjugated with CS into nanoscale spherical particles through hydrophobic interaction. The complexation of CS with HLDP remarkably improves the deposition and adhesion of CS droplets on mango leaves. The HLDP can interact with mycelium via electrostatic interaction to damage the cell wall/membrane, which can act as an AI to directly suppress the spore germination and mycelial growth. Meanwhile, HLDP can be applied as an adjuvant for CS to amplify the plant immune responses via accelerating the biosynthesis of secondary metabolites and plant hormones. This work reports the multiple missions for nanomaterials in pathogen control, which proposes a novel strategy for designing nano‐protectant with dual‐synergistic mechanism.
3D Crystal Construction by Single‐Crystal 2D Material Supercell Multiplying
Authors: Li Wenhao , Shen Jichuang , Ma Yaqing , Xu Xiang , Chen Han , Yu Lida , Ji Chen , He Menglin , Ma Kezhao , Duo Yiwei , Wang Li , Wei Tongbo , Shi Liping , Wu Muhong , Liu Kaihui , Zhu Huaze , Kong Wei 
Published: November 2024

Abstract2D stacking presents a promising avenue for creating periodic superstructures that unveil novel physical phenomena. While extensive research has focused on lateral 2D material superstructures formed through composition modulation and twisted moiré structures, the exploration of vertical periodicity in 2D material superstructures remains limited. Although weak van der Waals interfaces enable layer‐by‐layer vertical stacking, traditional methods struggle to control in‐plane crystal orientation over large areas, and the vertical dimension is constrained by unscalable, low‐throughput processes, preventing the achievement of global order structures. In this study, a supercell multiplying approach is introduced that enables high‐throughput construction of 3D superstructures on a macroscopic scale, utilizing artificially stacked single‐crystalline 2D multilayers as foundational repeating units. By employing wafer‐scale single‐crystalline 2D materials and referencing the crystal orientation of substrates, the method ensures precise alignment of crystal orientation within and across each supercell, thereby achieving controllable periodicity along all three axes. A centimeter‐scale 3R‐MoS₂ crystal is successfully constructed, comprising over 200 monolayers of single‐crystalline MoS₂, through a bottom‐up stacking process. Additionally, the approach accommodates the integration of amorphous oxide, enabling the assembly of 3D non‐linear optical crystals with quasi‐phase matching. This method paves the way for the bottom‐up construction of macroscopic artificial 3D crystals with atomic plane precision, enabling tailored optical, electrical, and thermal properties and advancing the development of novel artificial materials and high‐performance applications.
Microglial Lyzl4 Facilitates β‐Amyloid Clearance in Alzheimer's Disease
Authors: Pan Jie , Zhong Jie , Geng Ji , Oberhauser Jane , Shi Shihua , Wan Jun 
Published: November 2024

AbstractAlzheimer's Disease (AD) is a neurodegenerative condition characterized by the accumulation and deposition of amyloid‐β (Aβ) aggregates in the brain. Despite a wealth of research on the toxicity of Aβ and its role in synaptic damage, the mechanisms facilitating Aβ clearance are not yet fully understood. However, microglia, the primary immune cells of the central nervous system, are known to maintain homeostasis through the phagocytic clearance of protein aggregates and cellular debris. In this study, RNA sequencing analysis and live cell functional screens are employed to uncover microglial genetic modifiers related to AD. Lyzl4 is identified, which encodes a c‐type lysozyme‐like enzyme primarily localized to microglial lysosomes, as a gene significantly upregulated in AD microglia with aging and propose that Lyzl4 upregulation acts as a positive regulator of Aβ clearance. Furthermore, it is found that Lyzl4 overexpression boosts Aβ clearance both in vitro and in vivo, underscoring its potential for mitigating Aβ burden. These novel insights position Lyzl4 as a promising therapeutic target for Alzheimer's disease, paving the way for further exploration into potential AD treatments.
Ultrafast Sintering of Dense Li7La3Zr2O12 Membranes for Li Metal All‐Solid‐State Batteries
Authors: Okur Faruk , Zhang Huanyu , Baumgärtner Julian F. , Sivavec Jaka , Klimpel Matthias , Wasser Gregor Paul , Dubey Romain , Jeurgens Lars P.H. , Chernyshov Dmitry , van Beek Wouter , Kravchyk Kostiantyn V. , Kovalenko Maksym V. 
Published: November 2024

AbstractUltrafast sintering (UFS) is a compelling approach for fabricating Li7La3Zr2O12 (LLZO) solid‐state electrolytes (SSEs), paving the way for advancing and commercializing Li‐garnet solid‐state batteries. Although this method is commonly applied to the sintering of LLZO ceramics, its use for producing dense, phase‐pure LLZO SSEs has thus far been primarily limited to millimeter‐thick pellets, which are unsuitable for commercial solid‐state batteries. This study presents ultrafast sintering as a highly effective approach for fabricating self‐standing, dense, 45 µm‐thick LLZO membranes. The chemical and structural evolution of LLZO membranes during the UFS process is characterized through in situ synchrotron X‐ray diffraction and thermogravimetric analysis‐mass spectrometry, complemented by an in‐depth investigation of surface chemistry using X‐ray photoelectron spectroscopy. The membranes in Li/LLZO/Li symmetrical cell configuration exhibit a high critical current density of up to 12.5 mA cm−2 and maintain superior cycling stability for 250 cycles at a current density of 1 mA cm−2, with an areal capacity limit of 1 mAh cm−2. The electrochemical performance of LLZO membranes is also assessed in full cell configuration using a pyrochlore‐type iron (III) hydroxy fluoride cathode.
Comprehensive Modular Synthesis of Ganglioside Glycans and Evaluation of their Binding Affinities to Siglec‐7 and Siglec‐9
Authors: Adak Avijit K. , Tseng Hsin‐Kai , Chang Shu‐Yen , Chiang Yu‐Ching , Lyu Ke‐Hong , Lee Yun‐Sheng , Lu Wen , Kuo Wen‐Hua , Angata Takashi , Lin Chun‐Cheng 
Published: November 2024

AbstractIn the present work, bacterial glycosyltransferases are utilized to construct ganglioside glycans in a convergent approach via a sugar‒nucleotide regeneration system and one‐pot multienzyme reactions. Starting from β‐lactoside enables the diversification of both the glycan moieties and the linkages in the lower α‐arm and upper β‐arm. Overall, a comprehensive panel of 24 natural a‐series (GM3, GM2, GM1a, GD1a, GT1a, and fucosyl‐GM1), b‐series (GD3, GD2, GD1b, GT1b, and GQ1b), c‐series (GT3, GT2, GT1c, GQ1c, and GP1c), α‐series (GM1α, GD1aα, and GT1aα), and o‐series (GA2, GA1, GM1b, GalNAc‐GM1b, and GD1c) ganglioside glycans are prepared, which are suitable for biological studies and further applications. Moreover, a microarray is constructed with these synthesized ganglioside glycans to investigate their binding specificity with recombinant Fc‐fused Siglec‐7 and Siglec‐9, which are immune checkpoint‐like glycan recognition proteins on natural killer cells. The microarray binding results reveal that GD3 and GT1aα are specific ligands for Siglec‐7 and Siglec‐9, respectively, and this discovery can lead to the identification of appropriate ligands for investigating the roles of these Siglecs in immunomodulation.
Nanoengineering of Phosphate/Phosphonate Drugs via Competitive Replacement with Metal‐Phenolic Networks to Overcome Breast Tumor with Lung and Bone Metastasis
Authors: Shi Wanrui , Liu Dashuai , Feng Wenjie , Chen Yang , Wang Yonggang , Nie Zhihong , Liu Yi , Zhang Hao 
Published: November 2024

AbstractPhosphate and phosphonate drugs are vital in building organisms, regulating physiological processes, and exhibiting diverse biological activities, including antiviral, antibacterial, antineoplastic, and enzyme‐inhibitory effects. However, their therapeutic potential is limited by the lack of advanced nanoengineering technologies. Herein, a competitive coordination strategy for nanoengineering phosphate/phosphonate drugs is introduced. By leveraging the difference in coordination capabilities between polyphenols and phosphates/phosphonates with metal ions, various phosphate/phosphonate‐based nanodrugs using metal‐phenolic networks (MPNs) as templates and phosphate/phosphonate drugs as competitive agents are constructed. The dynamic nature of these coordination bonds imparts stimuli‐responsiveness to the nanodrugs, allowing for targeted release and therapy. As a proof of concept, Fe3+ and galangin are used to form the MPN template, zoledronic acid and cGAMP as competitive agents, and DOX as the loaded drug to construct DOX@Fe‐galangin@Fe‐zoledronic acid‐cGAMP nanodrugs. The results demonstrate that, by triggering pyroptosis and activating the cGAS‐STING pathway, the nanodrugs exhibit potent cytotoxicity and accurate selectivity in eradicating orthotopic breast tumors, and activate an antitumor immune response against lung and bone metastases. Because the competitive coordination strategy is applicable to a variety of phosphate/phosphonate agents, it holds significant potential for enhancing the clinical efficacy of phosphate/phosphonate drugs and advancing nanodrug development for complex therapeutic applications.
Rapid Prototyping for Accelerated Establishment of Film Processing‐Performance Relationships in Silicon Phthalocyanine OFETs
Authors: Cranston Rosemary R. , Mauthe Jacob , Wang Tonghui , Thapa Gaurab J. , Amassian Aram , Lessard Benoît H. 
Published: November 2024

AbstractUnderstanding the complex relationships underlying the performance of organic electronic devices, such as organic field‐effect transistors (OFETs), requires researchers to navigate a multi‐dimensional parameter space that includes material design, solution formulation, fabrication parameters, and device geometry. Herein, a recently developed materials acceleration platform is demonstrated, named the RoboMapper, to perform direct on‐chip fabrication of OFETs by ultrasonic meniscus printing using silicon phthalocyanine (SiPc) derivatives as the semiconductor. OFETs using bis(tri‐n‐butylsilyl oxide) SiPc ((3BS)2‐SiPc) exhibited the best device performance characterized by the highest electron field‐effect mobility (µe). Through optical microscopy and grazing‐incidence wide‐angle X‐ray scattering (GIWAXS), the favorable performance of (3BS)2‐SiPc is attributed to the specific film morphology and molecular packing achieved with optimal print conditions. Investigating the impact of deposition parameters reveals the crucial role of solvent evaporation rate and print speed in achieving high‐quality film formation. Overall, optimal fabrication conditions for (3BS)2‐SiPc devices include slow print speeds and fast evaporating solutions achieved by using a mixture of co‐solvents and an elevated substrate temperature. The results of this work reveal distinct relationships between deposition conditions, film properties, and device performance for each SiPc derivative and emphasize the necessity of high throughput experimentation to comprehensively understand process‐performance relationships in organic semiconductors.
Phosphoproteomic analysis of distylous Turnera subulata identifies pathways related to endoreduplication that correlate with reciprocal herkogamy
Authors: Henning Paige M. , Minkoff Benjamin B. , Sussman Michael R. 
Published: November 2024

AbstractPremiseA multi‐omic approach was used to explore proteins and networks hypothetically important for establishing filament dimorphisms in heterostylous Turnera subulata (Sm.) as an exploratory method to identify genes for future empirical research.MethodsMass spectrometry (MS) was used to identify differentially expressed proteins and differentially phosphorylated peptides in the developing filaments between the L‐ and S‐morphs. RNAseq was used to generate a co‐expression network of the developing filaments, MS data were mapped to the co‐expression network to identify hypothetical relationships between the S‐gene responsible for filament dimorphisms and differentially expressed proteins.ResultsMapping all MS identified proteins to a co‐expression network of the S‐morph's developing filaments identified several clusters containing SPH1 and other differentially expressed or phosphorylated proteins. Co‐expression analysis clustered CDKG2, a protein that induces endoreduplication, and SPH1—suggesting a shared biological function. MS analysis suggests that the protein is present and phosphorylated only in the S‐morph, and thus active only in the S‐morph. A series of CDKG2 regulators, including ATM1, and cell cycle regulators also correlated with the presence of reciprocal herkogamy, supporting our interest in the protein.ConclusionsThis work has built a foundation for future empirical work, specifically supporting the role of CDKG2 and ATM1 in promoting filament elongation in response to SPH1 perception.
Mini‐consolidations or intermediate‐dose cytarabine for the post‐remission therapy of AML patients over 60. A retrospective study from the DATAML and SAL registries
Authors: Récher Christian , Dumas Pierre‐Yves , Bérard Emilie , Tavitian Suzanne , Leguay Thibaut , Galtier Jean , Alric Camille , Bidet Audrey , Delabesse Eric , Rieu Jean Baptiste , Vial Jean‐Philippe , Vergez François , Luquet Isabelle , Klein Emilie , de Grande Anne‐Charlotte , Sarry Audrey , Zukunft Sven , Platzbecker Uwe , Müller‐Tidow Carsten , Baldus Claudia D. , Bornhäuser Martin , Serve Hubert , Bertoli Sarah , Pigneux Arnaud , Röllig Christoph 
Published: November 2024

AbstractAccording to current recommendations, older AML patients in first complete remission (CR) after induction chemotherapy should receive consolidation with intermediate‐dose cytarabine (IDAC). However, no study has demonstrated the superiority of IDAC over other regimen. In this retrospective study, we compared the efficacy of mini‐consolidations (idarubicin 8 mg/m2 day 1, cytarabine 50 mg/m2/12 h, day 1–5) and IDAC. Inclusion criteria were newly diagnosed AML, age > 60 years, first CR after induction and at least 1 cycle of consolidation. Of the 796 included patients, 322 patients received mini‐consolidations and 474 patients received IDAC. Mini‐consolidation patients were older, and more often, they had de novo AML and unfavorable risk. The rate of allogeneic transplantation was higher in the IDAC group. The median number of cycles was higher in the mini‐consolidation group (4 vs. 2; p < .0001). Median relapse‐free survival was 18 months with mini‐consolidations and 12 months with IDAC (p = .0064). In multivariate analysis, the risk of relapse or death was significantly higher in the IDAC group (p = .004). Median OS was 36 versus 31 months with mini‐consolidations or IDAC, respectively (p = .46). In multivariate analysis, the consolidation regimen had no significant influence on OS (p = .43). In older AML patients, post‐remission therapy with mini‐consolidations represents an alternative to IDAC.
The Glu86 Residue in TBX4 Proves Critical for Human Lung Development
Authors: Szafranski Przemyslaw , Gambin Tomasz , Deutsch Gail , Nassef Salma A. , Bailey Mary Clay , Kearney Debra L. , Stankiewicz Paweł 
Published: November 2024

ABSTRACTT‐box transcription factors are a group of evolutionarily conserved T‐box‐containing regulators of mesoderm specification and development. Heterozygous single nucleotide variants (SNVs) or copy‐number variant (CNV) deletions involving dosage‐sensitive TBX4 have been associated with pulmonary arterial hypertension (PAH), ischiocoxopodopatellar syndrome with or without PAH, and lethal lung developmental disorders (LLDDs), including acinar dysplasia (AcDys), congenital alveolar dysplasia (CAD), and other unspecified primary pulmonary hypoplasias. Loss‐ and gain‐of‐function variants have been proposed to cause pediatric PAH and LLDDs, and adult forms of PAH, respectively. Of more than 50 missense SNVs scattered across the entire TBX4, only three have been reported in patients with LLDDs, all mapping to the T‐box domain. Here, we report a recurrence of a pathogenic substitution Glu86Lys identified in an unrelated patient with AcDys. In silico predictions of the conformational changes of TBX4 resulting from this and another substitution, Glu86Gln, suggest the loss of most intermolecular hydrogen bonds involving residue 86, including those with Tyr230 that directly interact with DNA. Functional assays on the TBX4 variants in fetal lung fibroblasts confirmed their deleterious character. We propose that Glu86 is critically involved in maintaining TBX4 structure and function essential for airway branching during early stages of human lung development. Substitutions of this residue may act in a dominant negative manner, leading to AcDys and CAD.
TEMPO‐Mediated Cross‐Dehydrogenative Coupling for the Synthesis of Bis(indolyl)methanes
Authors: Guo You‐Qiang , Liang Long , Wang Zhen‐Yu , Wu Xiang , Li You‐Gui 
Published: November 2024

AbstractA TEMPO‐mediated method has been developed for the synthesis of bis(indolyl)‐methane derivatives by the cross‐dehydrogenative coupling between C(sp3)−H of para‐cresol derivatives and C(sp2)−H of indoles in moderate yields under aqueous conditions. This method utilizes toluene derivatives as starting materials, allowing for coupling without the need for further functionalization. The use of environmentally friendly water as a solvent minimizes waste generation. Electron‐donating groups such as methyl and methoxy, as well as halogens like fluorine, chlorine, and bromine, exhibit good tolerance in this process. Furthermore, a possible reaction mechanism is proposed to elucidate the formation of BIMs.
Optimization of Reaction Conditions for On‐DNA Synthesis of Ureas, Thioureas, and Sulfonamides
Authors: Migliorini Francesca , Ciamarone Andrea , Neri Dario , Cazzamalli Samuele , Favalli Nicholas 
Published: November 2024

AbstractIsocyanates, isothiocyanates, and sulfonyl chlorides can be found in valuable building blocks for the construction of DNA‐Encoded Chemical Libraries (DELs), leading to the generation of ureas, thioureas, and sulfonamides. We present the development of reaction conditions for the addition of isocyanates, isothiocyanates, and sulfonyl chlorides to single‐stranded oligonucleotides, with a focus on maximizing on‐DNA conversion while preserving DNA integrity. We explored and optimized reaction parameters to achieve efficient coupling and minimize DNA degradation and by‐product formation. The protocols reported in this paper broaden the scope of DNA‐compatible reactions and may be applicable to the construction of novel DELs.
N‐Heterocyclic Carbene Catalyzed Activation of Carboxylic Acids
Authors: Qin Yueling , Li Tingting 
Published: November 2024

AbstractN‐heterocyclic carbene (NHC) catalyzed reactions of carboxylic acids play a crucial role in NHC catalysis, enabling the formation of chiral and achiral functional molecules. In this review, the achievements in NHC catalyzed activations of carboxylic acids are summarized, and an outlook on future research directions is also provided.