bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders
Authors: Andlauer Till F. M. , Guzman-Parra Jose , Streit Fabian , Strohmaier Jana , González Maria José , Flores Susana Gil , Cabaleiro Fabeiro Francisco J. , del Río Noriega Francisco , Perez Fermin Perez , González Jesus Haro , Diaz Guillermo Orozco , de Diego-Otero Yolanda , Moreno-Kuestner Berta , Auburger Georg , Degenhardt Franziska , Heilmann-Heimbach Stefanie , Herms Stefan , Hoffmann Per , Frank Josef , Foo Jerome C. , Treutlein Jens , Witt Stephanie H. , Cichon Sven , Kogevinas Manolis ,   Bipolar Disorder Working Group of the Psychiatric Genomics Consortium,   Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Rivas Fabio , Mayoral Fermín , Müller-Myhsok Bertram , Forstner Andreas J. , Nöthen Markus M. , Rietschel Marcella 
Published: November 2018

AbstractMultiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families as well as 438 subjects from an independent, sporadic BD case-control cohort were analysed. Polygenic risk scores (PRS) for BD, schizophrenia, and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had significantly higher PRS for all three psychiatric disorders than the independent controls, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and sporadic BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses, therefore, demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. The PRS explained only part of the observed phenotypic variance and rare variants might have also contributed to disease development.
Into the light: effects of the presence of cleaning staff on customer experience
Authors: Vos Martijn C. , Sauren Jessica , Knoop Olaf , Galetzka Mirjam , Mobach Mark P. , Pruyn Ad T.H. 
Published: November 2018

PurposeThe purpose of this paper is to determine how the presence of cleaning staff affects perceptions and satisfaction of train passengers. Day-time cleaning is becoming increasingly popular in (public) service environments. It is however unknown how the presence of cleaning staff in the service environment affects perceptions and satisfaction of end-users.Design/methodology/approachTwo experimental field studies were performed. Data for the first study were collected on the trajectory between the train station of Assen and the station of Groningen (N= 506) in the northern part of the Netherlands. Data for the second study were collected on the trajectory between train station “Amsterdam Amstel” and train station “Utrecht Centraal” (N= 1,113) in the central part of the Netherlands. In the experimental condition, two cleaners collected waste and performed minor cleaning activities (i.e. empty trash bins, cleaning doors and tables) during the journey. After the first study, cleaners received hospitality training and corporate uniforms.FindingsThe presence of cleaning staff positively influenced train passengers’ perceptions and satisfaction. Effects were stronger in the second study, after the second consecutive intervention (i.e. hospitality training, corporate uniforms). In both studies, the presence of cleaners positively influenced passengers’ perceptions of staff, cleanliness and comfort. The perception of atmosphere was only significant after the intervention.Practical implicationsThe findings of this study allow in-house and corporate facility managers to better understand the possible effects of the presence of their cleaning staff on end-user perceptions and satisfaction.Originality/valueThe study’s value lies in its human centred approach by demonstrating the importance of day-time cleaning. This area of research has been largely neglected in the field of facilities and (public) services management research.
Roles and capacities of Thai family development centres
Authors: Supprasert Warunsicha , Hughes David , Khajornchaikul Piyatida 
Published: November 2018

PurposeThe purpose of this paper is to examine Family Development Centre (FDC) staff’s[1] perspectives on their roles and capacity to promote early childhood language learning through good parenting.Design/methodology/approachThis research employed in-depth interviews with 30 FDC coordinators and volunteer staff, supported by limited field observations.FindingsIdentifying risk, surveillance of at-risk families, building community solidarity and activities to support parenting and children, emerged as key components of FDC work. Volunteers softened their surveillance role by emphasising their social support function and personal links to local communities. Most activities aimed to strengthen family bonding and relationships, with fewer specifically addressing early childhood language deficits. Volunteers found the latter challenging, and generally sought to work in cooperation with education, public health and child care staff where projects involved language development.Practical implicationsMost volunteers said they lacked the capacities to promote early language development effectively and required additional training in such areas as partnerships and collaboration, family and parenting support, and project management. The authors argue that the importance given to partnerships reflects volunteers’ recognition that they need to draw on outside expertise to address children’s language problems. Given resource constraints, volunteers will remain central to family support work for the immediate future. Even with training lay volunteers will not become language experts, and future policy should centre on building a framework of professional support for the community teams.Originality/valueThis study fills a gap in knowledge about FDC volunteer roles and suggests a need for training that focuses on teamwork rather than specialist language expertise.
Location impact on source and linguistic features for information credibility of social media
Authors: Aladhadh Suliman , Zhang Xiuzhen , Sanderson Mark 
Published: November 2018

PurposeSocial media platforms provide a source of information about events. However, this information may not be credible, and the distance between an information source and the event may impact on that credibility. Therefore, the purpose of this paper is to address an understanding of the relationship between sources, physical distance from that event and the impact on credibility in social media.Design/methodology/approachIn this paper, the authors focus on the impact of location on the distribution of content sources (informativeness and source) for different events, and identify the semantic features of the sources and the content of different credibility levels.FindingsThe study found that source location impacts on the number of sources across different events. Location also impacts on the proportion of semantic features in social media content.Research limitations/implicationsThis study illustrated the influence of location on credibility in social media. The study provided an overview of the relationship between content types including semantic features, the source and event locations. However, the authors will include the findings of this study to build the credibility model in the future research.Practical implicationsThe results of this study provide a new understanding of reasons behind the overestimation problem in current credibility models when applied to different domains: such models need to be trained on data from the same place of event, as that can make the model more stable.Originality/valueThis study investigates several events – including crisis, politics and entertainment – with steady methodology. This gives new insights about the distribution of sources, credibility and other information types within and outside the country of an event. Also, this study used the power of location to find alternative approaches to assess credibility in social media.
An exploratory approach to the computational quantification of journalistic values
Authors: Choi Sujin 
Published: November 2018

PurposeNews algorithms not only help the authors to efficiently navigate the sea of available information, but also frame information in ways that influence public discourse and citizenship. Indeed, the likelihood that readers will be exposed to and read given news articles is structured into news algorithms. Thus, ensuring that news algorithms uphold journalistic values is crucial. In this regard, the purpose of this paper is to quantify journalistic values to make them readable by algorithms through taking an exploratory approach to a question that has not been previously investigated.Design/methodology/approachThe author matched the textual indices (extracted from natural language processing/automated content analysis) with human conceptions of journalistic values (derived from survey analysis) by implementing partial least squares path modeling.FindingsThe results suggest that the numbers of words or quotes news articles contain have a strong association with the survey respondent assessments of their balance, diversity, importance and factuality. Linguistic polarization was an inverse indicator of respondents’ perception of balance, diversity and importance. While linguistic intensity was useful for gauging respondents’ perception of sensationalism, it was an ineffective indicator of importance and factuality. The numbers of adverbs and adjectives were useful for estimating respondents’ perceptions of factuality and sensationalism. In addition, the greater numbers of quotes, pair quotes and exclamation/question marks in news headlines were associated with respondents’ perception of lower journalistic values. The author also found that the assessment of journalistic values influences the perception of news credibility.Research limitations/implicationsThis study has implications for computational journalism, credibility research and news algorithm development.Originality/valueIt represents the first attempt to quantify human conceptions of journalistic values with textual indices.
Quantitative integration of 3D and 4D seismic impedance into reservoir simulation model updating in the Norne Field
Authors: Maleki Masoud , Davolio Alessandra , Schiozer Denis José 
Published: November 2018

ABSTRACTThe ultimate goal of reservoir simulation in reservoir surveillance technology is to estimate long‐term production forecasting and to plan development and management of petroleum fields. However, maintaining reliable reservoir models which honour available static and dynamic data, involve inherent risks due to the uncertainties in space and time of the distribution of hydrocarbons inside reservoirs. Recent applications have shown that these uncertainties can be reduced by quantitative integration of seismic data into the reservoir modelling workflows to identify which areas and reservoir attributes of the model should be updated. This work aims using seismic data to reduce ambiguity in calibrating reservoir flow simulation model with an uncertain petro‐elastic model, proposing a circular workflow of inverted seismic impedance (3D and 4D) and engineering studies, with emphasis on the interface between static and dynamic models. The main contribution is to develop an updating procedure for adjusting reservoir simulation response before using it in the production forecasting and enhance the interpretive capability of reservoir properties. Accordingly, the workflow evaluates consistency of reservoir simulation model and inverted seismic impedance, assisted by production history data, to close the loop between reservoir engineering and seismic domains. The methodology is evaluated in a complex, faulted, sandstone reservoir, the Norne benchmark field, where a significant reservoir behaviour understanding (about the static and dynamic reservoir properties) is obtained towards the quantitative integration of seismic impedance data. This leads to diagnosis of the reservoir flow simulation reliability and generation of an updated simulation model consistent with observed seismic and well production history data, as well as a calibrated petro‐elastic model. Furthermore, as Norne Field is a benchmark case, this study can be considered to enrich the discussions over deterministic or probabilistic history matching studies.
Superannuation in Australia: A Survey of the Literature
Authors: Kingston Geoffrey , Thorp Susan 
Published: November 2018

In 2017 Australian superannuation assets stood at 148 per cent of GDP, or $2.5 trillion in absolute terms. This was the world's fourth largest pool of retirement savings, a remarkable outcome over 25 years of the operation of the Superannuation Guarantee. We survey the local academic, industry and policy literature on the economics of superannuation during the last quarter of a century. Topics include the policy debate, the positive, normative and behavioural economics of household interaction with superannuation, and the structure, conduct and performance of the superannuation industry. We encourage further research into effective tax rates, the need to hedge human capital and the automation of financial advice.
Neutrophil‐to‐lymphocyte ratio, mean platelet volume and platelet‐to‐lymphocyte ratio in Behçet’s disease and their correlation with disease activity: A meta‐analysis
Authors: Lee Young Ho , Song Gwan Gyu 
Published: November 2018

AbstractAimWe aimed to evaluate the relationship between mean platelet volume (MPV), neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and Behçet’s disease (BD).MethodsWe searched Medline, Embase, and Cochrane databases, and performed a meta‐analysis to compare MPV, NLR, and PLR between patients with BD and healthy controls, and to evaluate these parameters in BD according to disease activity and thrombosis.ResultsIn total, 14 studies were included. MPV was not higher in the BD group than in the control group (standardized mean difference [SMD], 0163; 95% confidence interval [CI], −0.125 to 0.451; P = 0.268), while NLR was significantly higher in the BD group than in the control group (SMD, 1.176; 95% CI, 0.392‐1.960, P = 0.003) and PLR showed a non‐significant trend of association with BD (SMD, 0.441; 95% CI, −0.025 to 0.907, P = 0.063). MPV did not differ between patients with active and inactive BD (SMD, −0.129; 95% CI, −0.323 to 0.085, P = 0.191), and between patients with BD with and without thrombosis (SMD, 0.231; 95% CI, −0.155 to 0.617, P = 0.241). Conversely, NLR was significantly higher in patients with active BD than in those with inactive BD (SMD, 1.774; 95% CI, 0.179‐3.368, P = 0.029), but not significantly higher in patients with BD with thrombosis than in those without thrombosis (SMD, 0.258; 95% CI, −0.277 to 0.792, P = 0.345).ConclusionsThis finding suggests that NLR may be a potential index to evaluate the disease activity of BD, although there are limitations of small number of studies and heterogeneity of individual characteristics.
Evolutionary distinctiveness and conservation priorities in a large radiation of songbirds
Authors: Funk E. R. , Burns K. J. 
Published: November 2018

AbstractHuman‐induced impacts such as climate change and habitat alterations, coupled with limits on funding, have forced conservation actions into a mode of triage. Although no current method has been agreed upon as the best approach to select species for conservation, many studies have demonstrated the utility of incorporating phylogenetic diversity into these decisions. In many cases, degree of phylogenetic relatedness is thought to provide a measure of functional diversity, and greater phylogenetic distinctiveness is likely linked to ecosystem stability. Despite recent debate over the validity of this notion, phylogenetic information remains an important factor to consider in evaluating species and regions for conservation attention. Emberizoidea is a large radiation of 830 species, representing roughly 17% of all songbirds and 8% of all birds. Species in this clade are found throughout the Americas and occur in all terrestrial biomes in the region. The large distribution of this clade, coupled with its morphological and ecological diversity, makes it an important radiation to study from an evolutionary and conservation perspective. This study provides conservation priorities for all species in Emberizoidea using evolutionary distinctiveness (ED) and Evolutionarily Distinct and Globally Endangered (EDGE) values from a pseudoposterior distribution of time‐calibrated supertrees. We found that threat level is not correlated with degree of ED, indicating that the most threatened species do not represent a disproportionate amount of ED. In addition, threatened species are slightly clustered across the phylogeny, indicating similar threats may be affecting groups of closely related species such as island radiations or geographically restricted radiations in highly disturbed regions.
Evaluation of varenicline usage on ventricular repolarization after smoking cessation
Authors: Yıldırım Duygu İlke , Hayıroğlu Mert İlker , Ünal Neriman , Eryılmaz Mehmet Ali 
Published: November 2018

AbstractBackgroundVarenicline, which is a selective partial agonist of the alpha4–beta2 nicotinic acetylcholine receptor, is used for the smoking cessation pharmacotherapy. Cardiovascular adverse effects have been reported after varenicline usage in patients who stop smoking. We investigated the effect of varenicline usage on ventricular repolarization after smoking cessation.MethodsIn this prospective cohort study, we evaluated the cardiac arrhythmic effects of varenicline by comparing smoking patients (n = 214) before and after varenicline usage. Varenicline administered patients were also compared to ex‐smoker individuals (n = 50) who quit smoking without varenicline usage in terms of ventricular repolarization parameters.ResultsAfter calculated according to Fridericia's and Framingham's formulas, QTc intervals were significantly increased when patients compared before and after smoking cessation with varenicline (402.9 ± 24.5 ms vs. 409.1 ± 25.0 ms p < 0.001 and 376.5 ± 15.2 ms, vs. 380.6 ± 13.5 ms; p < 0.001, respectively). There was no arrhythmic event during the follow‐up. The change in Tp‐e and QTc following varenicline usage was negatively correlated with the smoking packet/year. (ρ: −0.443, p < 0.001 and ρ = −0.601, p < 0.001)ConclusionVarenicline usage was demonstrated to prolong ventricular repolarization parameters similar to animal studies. Varenicline may have a role to predispose cardiac dysrhythmias after utilization in smoking cessation.
Territorial (In) Coherence: Labour and Special Economic Zones in Laos's Border Manufacturing
Authors: Brown James Alan 
Published: November 2018

AbstractThis article engages literature on special economic zones and territory in global development. I suggest a focus on labour's spatial class composition as constitutive of territorial coherence provides insights into how the Savan‐Seno Special Economic Zone in Lao PDR operates as an economic border territory bridging Laos to the regional and global economies. The distanciated global connections which special economic zones aim to create are predicated on zones gaining internal coherence for capital accumulation. I suggest zones’ internal coherence depends on zone firms reworking the local class composition of labour, itself constituted by workers’ spatial practices. In the Savan‐Seno zone this occurred through immobilising a mobile labour force and taking advantage of its continuing embeddedness within a subsistence rice‐producing village economy. The argument aims to illustrate how zones producing for global markets act as territories of complex spatiality which span and connect multiple spaces of production and workers’ social reproduction.
Loss of paraspinal muscle mass is a gender‐specific consequence of cirrhosis that predicts complications and death
Authors: Engelmann Cornelius , Schob Stefan , Nonnenmacher Ines , Werlich Luise , Aehling Niklas , Ullrich Sebastian , Kaiser Thorsten , Krohn Sandra , Herber Adam , Sucher Robert , Bartels Michael , Surov Alexey , Hasenclever Dirk , Kahn Thomas , Seehofer Daniel , Moche Michael , Berg Thomas 
Published: November 2018

SummaryBackgroundLoss of skeletal muscle mass is a recognised complication with a prognostic impact in patients with cirrhosis.AimTo explore in a retrospective analysis which muscle compartment most reliably predicts the occurrence of cirrhosis‐associated complications and if there are gender‐related differences.Methods795 patients with cirrhosis listed for liver transplantation between 2001 and 2014 met the inclusion and exclusion criteria including an abdominal CT scan (±200). Controls were 109 patients who underwent a CT scan after polytrauma. The paraspinal muscles index (PSMI), the abdominal wall muscles index (AWMI) and its combination skeletal muscle index (SMI) were assessed at L3/L4, normalised to the height (cm2/m2).Results62.0% of patients with cirrhosis had alcoholic liver disease, and 70.6% were male. As compared to controls, a reduction in PSMI and SMI but not AWMI was associated with high model of end‐stage liver disease (MELD) score, high Child‐Pugh class, and the presence or history of cirrhosis‐associated complications in males but not females. PSMI independently predicted the occurrence of bacterial infections (HR 0.932), spontaneous bacterial peritonitis (HR 0.901), hepatic encephalopathy (HR 0.961), and hepatorenal syndrome (HR 0.946) by multivariate Cox regression analysis in a gender‐independent manner. Post‐transplant survival was not associated with the PSMI; neither AWMI nor SMI predicted any clinical endpoints.ConclusionsThis study links muscle wasting in patients with cirrhosis predominantly to males. However, the presence of a low PSMI mass is a gender‐independent predictor of developing cirrhosis‐associated complications and death. Scores combining the MELD with muscle parameters should be re‐validated by utilizing the PSMI.