bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a well-functioning stock market in context
Authors: Haslam Jim , Ji Jiao , Sun Hanwen 
Published: June 2018

Purpose
The purpose of this paper is to summarise and reflect upon key issues at the interface of prices, information and regulation with a focus upon the stock market in context. Reflecting upon academic research in the area of efficient markets, and regulatory policy, the concern is to discern issues in terms of policy and support for policy. What does the research imply for policy? Is it possible that the research, perhaps given its rhetoric, can be misinterpreted in relation to policy? The study is also concerned to develop avenues for future research based on these considerations.

Design/methodology/approach
The paper is an analytical and critical review and writing.

Findings
The reading of the research suggests a pragmatic regulatory policy that should be concerned to improve stock market functioning, including with respect to information, as well as the context of which this is part. At the same time, the literature may be read as promoting anti-regulatory policy.

Practical implications
On the one hand, these are consistent with the pragmatic policy referred to above. On the other hand, further research is suggested to explore substantively the rhetoric of the research and its interpretation and to explore understandings of the research and its implications amongst key constituencies in practice.

Originality/value
The concern is to bring key insights from the academic literature together with a view to promoting a pragmatic policy orientation, while cautioning in a critical perspective about how this academic literature and research might be interpreted from a policy perspective.
Audit fees via an indirect payment channel and professional skepticism
Authors: Kim Sanghun , Kim Taewoo , Pae Sujin , Kim Sangphill 
Published: June 2018

PurposeThis paper aims to examine the merit of an indirect payment system for audit fees, a system where an intermediary collects fees from the auditee and then pays this audit fee to the auditor.Design/methodology/approachBig 4 auditors and professional analysts in South Korea participated in an experiment and survey to investigate whether the change in the payment channel (from direct to indirect) of audit fees positively impacts auditors’ decision-making.FindingsThe authors find evidence that the indirect payment of audit fees is positively associated with professional skepticism.Research limitations/implicationsThis paper, by highlighting the potential for alternate auditor payment channels to improve the quality of auditor judgments, motivates future research in this area.Practical implicationsQualified by the need for further research, the potential merit in an indirect payment system may have implications for audit regulators.Social implicationsAn indirect payment channel has the potential to improve public perceptions of the audit function, thereby elevating society’s confidence in auditor opinions and improving the effectiveness and efficiency with which scarce resources are distributed within society.Originality/valueThis study is one of the first that looks into a systematic change in audit fee payment channel and how an indirect payment system of audit fees impacts professional skepticism.
Impact of CSR on learning outcomes
Authors: Sinha Shiv Nath , Chaudhari Tushar 
Published: June 2018

PurposeThe purpose of this paper is to examine the impact of CSR initiative of ITC Limited on the stakeholders especially impact on the learning outcome of primary school students. The research further attempts to discover the level of impact of CSR on learning outcomes.Design/methodology/approachThe data were collected from the rural areas of Pune in the state of Maharashtra and Mysuru in the state of Karnataka in India. The total number of data collected was 227. The data were collected with the help of self-administered questionnaires via personal visits to the schools using systematic random sampling method. Parametric test,t-test is used to test research hypothesis. Multiple linear regression analysis is performed to identify which aspects have better contribution towards overall impact level of the CSR program.FindingsThe study results clearly underscore the impact of firm’s CSR activities on the stakeholders. The study findings suggest a significant impact of CSR on the stakeholder, primarily on the learning outcome of the primary school students.Practical implicationsThe study offers a new insight for the CSR heads of companies who are planning and implementing CSR initiatives of companies for widespread impact on the stakeholders. This study addresses the concerns of business managers and CSR heads to prove the potential of CSR initiatives and the measurement of the value generated for the society through CSR interventions.Originality/valueThe previously conducted research works have explored the impact of CSR on financial performance, organizational stability, employee turnover, customer retention, etc. This study advances existing body of knowledge beyond developed western economies by exploring the value of CSR in India and its impact on the stakeholders. This study finds the impact of CSR initiative on learning outcome. The study makes a novel contribution by not only determining the impact of CSR on learning outcome but also by going a step further to unfurl the various underlying factors which contribute towards the overall impact.
Development of a custom zygomatic implant using metal sintering
Authors: Meena Vijay Kumar , Gagandeep Gagandeep , Aneesh Aneesh , Rattan Vidya , Luthra Gaurav , Kalra Parveen 
Published: June 2018

Purpose
The purpose of this paper is to design and development of a patient-specific implant for zygomatic area of a patient suffering from mucormycosis (fungal infection). The paper describes how integration of computer-aided design (CAD) and 3D printing can be successfully used for developing custom implants for the sites for which readymade optimal solutions are not available.

Design/methodology/approach
The CT scan data of the patient were used for the generation of a 3D model. The healthy side of skull was mirrored and copied on the infected part, which served as a base for designing the implant. The prototype of the implant was printed using fused deposition modelling before finally printing in Ti6Al4V alloy using direct metal laser sintering process.

Findings
The custom designed implant fitted well to the patient’s skull during surgery. Proper facial aesthetics were maintained post-surgery.

Originality/value
The work describes the application of CAD-based image processing software and additive manufacturing in the development of a custom implant for the sites for which no readymade optimal solution is available.
A new method for single-layer-part nesting in additive manufacturing
Authors: Zhang Yicha , Bernard Alain , Harik Ramy , Fadel Georges 
Published: June 2018

Purpose
This paper aims to introduce a new nesting scheme to better describe and solve the single-layer-part packing problem in additive manufacturing (AM).

Design/methodology/approach
Parallel nesting scheme using two-dimensional (2D) changeable projection profiles is developed. At first, a feature-based orientation optimization method is used to identify a set of practical alternative build orientations for each part to ensure the part quality. Then, 2D polygons are used to represent each part’s projection profiles under its alternative build orientations. Finally, a parallel layout searching algorithm is developed to identify the optimal part layout by using 2D changeable projection profiles.

Findings
The proposed nesting scheme can both guarantee the production quality for each part and search the optimal part layout with larger probability but less computational time.

Originality/value
With the use of changeable 2D projection profiles, this method conducts 2D computation to solve the single-layer-part packing problem with five degrees of freedom, which saves much computation cost and, at the same time, guarantees the production quality of each part. By adding specific nesting objectives or constraints and heuristic searching knowledge to the proposed nesting scheme, practical nesting software can be developed to meet the specific nesting or packing requirements for industrial AM machines.
Smart destinations and tech-savvy millennial tourists: hype versus reality
Authors: Femenia-Serra Francisco , Perles-Ribes José F. , Ivars-Baidal Josep A. 
Published: June 2018

PurposeThis paper aims to contrast the expectations placed on the smart destination as a theoretical management approach with the reality of emergent tech-savvy tourism demand by examining the response of this segment to three critical dimensions of technology use in the context of smart destinations. Tech-savvy tourists are here represented by highly educated Spanish millennial tourists.Design/methodology/approachData were obtained through an online survey and analysed through descriptive techniques and exploratory factor analysis using SPSS. Literature review was critical for setting the foundations of the research in this novel context.FindingsResults suggest the existence of a gap between the smart destination theoretical expectations and created hype and the real response of the examined demand in the three main scopes for this tourist-smart destination technology-based relationship, namely, mobile technology use, data sharing for personalised experiences and smart technologies for enhanced experiences.Research limitations/implicationsConvenience sampling was used, and the results of the study cannot be generalised to all millennial tourists. The research is a first approximation to the interrelationship between tourists and smart destinations.Practical/implicationsTourists’ role and experiences mediated by information and communication technologies (ICTs) are decisive in smart destinations. Destination Management Organisations (DMOs), through their policies and actions, ought to take into account the limited predisposition of tourists in using mobile devices, sharing data and using smart technologies for their experiences. Privacy concerns appear to have special relevance for tourists and, therefore, for the future of smart destinations.Originality/valueThe findings offer relevant insights for smart destinations from a neglected angle hitherto, as they introduce several interesting nuances which do not match entirely the fast track taken by institutions, media and academia. This is critical for better understanding tourists in the current panorama, for DMOs and for the theoretical foundations of smart tourism. Besides, the exploratory data analysis reveals potential dimensions of millennials’ behaviour, which can be useful for further investigations.
Contribution of peroxisomal docking machinery to mycotoxin biosynthesis, pathogenicity and pexophagy in the plant pathogenic fungus Fusarium graminearum
Authors: Chen Yun , Zheng Shiyu , Ju Zhenzhen , Zhang Chengqi , Tang Guangfei , Wang Jing , Wen Ziyue , Chen Wei , Ma Zhonghua 
Published: June 2018

SummaryPeroxisomal proliferation is highly stimulated during the biosynthesis of mycotoxins and plant infection by Fusarium graminearum. Currently, the functions of the peroxisome in these cellular processes are poorly understood. In this study, we applied genetic, cell biological and biochemical analyses to investigate the functions of the peroxisomes. We constructed targeted deletion of docking machinery components, including FgPex13, FgPex14 and the filamentous fungal specific peroxin FgPex33. Our results indicated that peroxisome dysfunction resulted in a shortage of acetyl‐CoA, the precursor of trichothecene biosynthesis, and subsequently decreased deoxynivalenol (DON) production. Deletion mutants of ΔFgPex13, ΔFgPex14 or ΔFgPex33 showed an increased accumulation of endogenous reactive oxygen species (ROS) and reduced phosphorylation of MAP (Mitogen‐Activated Protein) kinase FgMgv1. In addition, mutants of the docking peroxin exhibited increased sensitivity toward host oxidative bursts and cell wall integrity stress agents and reduced virulence on host plants. More importantly, we found for the first time that FgPex14 is required for pexophagy in F. graminearum. Overall, our study suggests that peroxisomes play critical roles in DON biosynthesis and virulence in F. graminearum.
Mortality in schizophrenia: 30‐year nationwide follow‐up study
Authors: Tanskanen A. , Tiihonen J. , Taipale H. 
Published: June 2018

ObjectiveRecent reports suggest that the mortality gap between persons with schizophrenia and the general population is increasing. We investigated the mortality, age at death, and causes of death among persons diagnosed with schizophrenia and the general population in Finland during 1984–2014.MethodsAll persons with schizophrenia in Finland were identified from hospital discharge register, and compared with the Finnish population aged 16 years and older during 1984–2014, based on data from Statistics Finland. Age at death and standardized mortality ratio (SMR) were calculated for each follow‐up year.ResultsMean age at death increased from 57.6 years in 1984 to 70.1 years in 2014 in persons with schizophrenia, and from 70.9 to 77.5 years in the general population. All‐cause SMR remained stable during the follow‐up (2.6 in 1984 and 2.7 in 2014). A major change was observed in SMR for suicides which decreased from 11.0 in 1984 to 6.6 in 2014 (−40%). The SMRs for cardiovascular and cancer deaths showed increasing trends.ConclusionThe longevity of persons with schizophrenia is improving at approximately the same rate as the general population but suicide rates have declined substantially. However, there is still a major disparity in mortality compared with general population.
What defines a clinically meaningful outcome in the treatment of substance use disorders: reductions in direct consequences of drug use or improvement in overall functioning?
Authors: Kiluk Brian D. , Fitzmaurice Garrett M. , Strain Eric C. , Weiss Roger D. 
Published: June 2018

AbstractBackgroundSustained abstinence is currently the only accepted end‐point for pharmacotherapy trials for most substance use disorders (SUD), with the exception of alcohol. Despite recent efforts, the identification of a non‐abstinence alternative as a clinically meaningful end‐point for drug use trials has been elusive.Argument and analysisThe current standard for establishing a clinically meaningful outcome in SUD trials is to demonstrate that a reduction in drug use is associated with improvement in long‐term functioning, but data indicate relatively weak associations between drug use and various psychosocial problem domains. This may be because assessments used most commonly to measure an individual's functioning do not specify whether aspects of functioning are a direct consequence of drug use. The acceptance of a non‐abstinence‐based end‐point for alcohol use disorder trials was supported in part through associations with reductions in alcohol‐related consequences, although measures designed to assess the direct consequences of drug use are rarely included in drug treatment efficacy trials.ConclusionsThe field of substance use disorders should include measures of negative psychosocial and health consequences of drug use, as opposed to overall functioning, in the effort to establish meaningful non‐abstinence‐based end‐points.
RAGE‐dependent VCAM‐1 expression in the lung endothelium mediates IL‐33‐induced allergic airway inflammation
Authors: Perkins T. N. , Oczypok E. A. , Milutinovic P. S. , Dutz R. E. , Oury T. D. 
Published: June 2018

AbstractBackgroundThe receptor for advanced glycation endproducts (RAGE) has been implicated as a critical molecule in the pathogenesis of experimental asthma/allergic airway inflammation (AAI). It has been previously shown that RAGE acts both upstream of interleukin‐33 (IL‐33) release and downstream of IL‐33 release via RAGE‐dependent IL‐33‐induced accumulation of type 2 innate lymphoid cells (ILC2s) in the lungs, which perpetuate type 2 inflammation and mucus metaplasia. However, the mechanism by which RAGE mediates downstream IL‐33‐induced type 2 inflammatory responses is unknown.ObjectiveThis study tested the hypothesis that ILC2s are recruited to the lungs via RAGE‐dependent vascular cell adhesion molecule 1 (VCAM‐1) expression on lung endothelial cells.MethodsHouse dust mite extract, Alternaria alternata extract, or rIL‐33 was used to induce AAI/VCAM‐1 expression in wild‐type (WT) and RAGE‐knockout (RAGE‐KO) mice. Intravenous (i.v.) anti‐VCAM‐1 or intraperitoneal (i.p.) β7 blocking antibody administration was used to determine the role of VCAM‐1 in IL‐33‐induced AAI.ResultsEnhanced VCAM‐1 expression in the lungs by HDM, AA, or rIL‐33 exposure was found to be RAGE‐dependent. In addition, stimulation of primary mouse lung endothelial cells with IL‐33 induced VCAM‐1 expression in WT, but not RAGE‐KO cells. Administration of VCAM‐1 and β7‐integrin blocking antibodies reduced IL‐33‐induced eosinophilic inflammation, mucus metaplasia, and type 2 inflammatory responses.ConclusionThis study demonstrates that allergen‐ and cytokine‐induced VCAM‐1 expression is RAGE‐dependent and contributes to lung ILC2 accumulation and downstream eosinophilic inflammation, mucus metaplasia, and type 2 inflammatory responses.
A qualitative study of midwives’ perceptions on using video‐calling in early labor
Authors: Spiby Helen , Faucher Mary Ann , Sands Gina , Roberts Julie , Kennedy Holly Powell 
Published: June 2018

AbstractBackgroundDecisions made in early labor influence the outcomes of childbirth for women and infants. Telephone assessment during labor, the current norm in many settings, has been found to be a source of dissatisfaction for women and can present challenges for midwives. The aim of this qualitative study was to explore midwives’ views on the potential of video‐calling as a method for assessing women in early labor.MethodsA series of 8 midwife focus groups (n = 45) and interviews (n = 4) in the Midlands region of England and the mid‐South and Northeast regions of the United States were completed. Audio recordings were transcribed verbatim and coded using content analysis. Coding diagrams were used to help develop major themes in the data.ResultsMidwives were generally positive about the potential of video‐calling in early labor and using visual cues to make more accurate assessments and to enhance trust. Some midwives expressed concerns about privacy, both for themselves and for women, and issues of accessibility. They suggested strategies for implementation and further research, such as the need for a private space in birth facilities and training for both staff and service users.ConclusionsVideo‐calling was seen as a viable option for assessment of women in early labor with some particular challenges related to implementation. This research focused on midwives’ views; the views of women and their families should also be considered. There is a lack of evidence on the clinical and cost effectiveness of video‐calling in maternity care and further research is warranted.
L'emprunt de termes génériques français dans la toponymie des États‐Unis d'Amérique, un état des lieux
Authors: Léonard Carol J. , Díez González Estrella 
Published: June 2018

Messages clés

Nous avons identifié sept lexies empruntées à la langue française par l'anglo‐américain dont le nombre d'occurrences est suffisant pour témoigner de la réalité de L'emprunt.
Ces lexies empruntées qui œuvrent en tant que génériques toponymiques sont : butte, chute, coulée/coulee, plateau, portage, prairie et rapid/rapids.
La région du Nord‐Est des États‐Unis se distingue de toutes les autres en cela qu'un seul des termes génériques étudiés s'y retrouve dans les toponymes hybrides identifiés.
Use of point‐of‐care HbA1c measurement to estimate the level of undiagnosed diabetes mellitus among 67‐year‐old participants in a cardiovascular screening programme in the municipality of Viborg, Denmark
Authors: Andersen J. W. , Dahl M. , Yderstraede K. B. , Hoegh A. 
Published: June 2018

AbstractAimsTo determine the prevalence of unidentified diabetes mellitus among 67‐year‐olds in Denmark participating in a screening programme focusing on cardiovascular disease and diabetes, and to describe glycaemic levels in individuals according to point‐of‐care HbA1c combined with self‐reported diabetes status.MethodsIn this cross‐sectional, retrospective, population‐based study, all people aged 67 years living in the Viborg municipality were invited to take part in the Viborg Inter‐sectorial Screening Programme (VISP), which focuses on cardiovascular disease and diabetes. The VISP study was initiated in August 2014 and is ongoing. During the first 2 years of the programme, we stratified participants into groups based on their self‐reported diabetes status and a single HbA1c measurement.ResultsA total of 1802 individuals were invited to participate, and 1501 consented, seven of whom were excluded because of missing data (HbA1c or diabetes status), resulting in an 82.9% participation rate (n=1494). Among those reporting not to have diabetes, 3.3% (n=45) had an HbA1c level ≥48 mmol/mol (6.5%). In the same group, 16.7% (n=226) had an HbA1c level of 41–48 mmol/mol (5.9–6.5%). Among those self‐reporting the presence of diabetes, 30.1% (n=43) had an HbA1c level ≥58 mmol/mol (7.5%).ConclusionsThe prevalence of unidentified diabetes was 3.3% based on a single HbA1c measurement. Furthermore, 16.7% of those reporting not to have diabetes had an HbA1c level of 41–48 mmol/mol (5.9–6.5%), representing a subgroup with an increased risk of developing diabetes. Among those with self‐reported diabetes, 30.1% had an HbA1c level ≥58 mmol/mol (7.5%) and 6.3% had a level >74 mmol/mol (8.9%).
Appropriate application of information from biodiversity databases is critical when investigating species distributions and diversity: a comment on Dallas et al. ()
Authors: Knouft Jason H. 
Published: June 2018

AbstractUsing data from biodiversity informatics resources, Dallas et al. (Ecol. Lett., 20, 2017, 1526–1533) suggested limited relationships between climate and local abundance among several taxonomic groups. Investigation of a subset of these data suggests that their results may be misleading due to inappropriate application of the biodiversity data.