bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encapsulated Fish Oil Products Available in the UK Meet Regulatory Guidelines With Respect to EPA + DHA Contents and Oxidative Status
Authors: Sprague Matthew , Cooper Sean , Tocher Douglas R. , Betancor Mónica B. 
Published: August 2018

Encapsulated fish oil products continue to be of high interest, particularly concerning labeling claims and oxidative status. Thus, the present study analyzes 23 encapsulated fish oil products from the UK for their lipid and fatty acid composition as well as oxidation parameters. Oil contents range from 91.4% to 118.9% of the manufacturers' stated level. Lipid class analyses reveals three different types of oil products consisting of either triacylglycerol (TAG), ethyl ester (EE), or in combination (EE/TAG). Fatty acid profiles vary according to oil form with long‐chain omega‐3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), more concentrated in EE compared to TAG‐based oils with TAG/EE oils containing intermediary levels. Twelve products have EPA + DHA contents lower than advertised, although this is reduced to 11 when the actual measured capsule oil content is taken into consideration. All products have peroxide (PV) and anisidine values below those set by pharmacopeias, although four products have a PV above the industry set limit of 5 meq kg−1. No relationships are found between oxidative parameters and missing EPA + DHA contents, although a significant relationship is observed between PV and days to expiry. In summary, encapsulated fish oil products on the UK market are not oxidized and meet regulatory guidelines with respect to EPA + DHA contents and oxidative status.Practical Applications: The study highlights the importance of quantifying the actual capsule oil content when determining EPA + DHA levels with respect to label claims. Furthermore, it also places results into context regarding regulatory guidelines demonstrating to regulatory bodies and consumers alike that UK fish oil products do meet specification and are not oxidized.The capsule oil content, lipid class composition, EPA+DHA content, and oxidative status of commercially available fish oil capsules are tested to see if products meet stated values and are not oxidized. The outcome shows that encapsulated fish oil products available in the UK do meet specification with regards to EPA+DHA levels and are not oxidized.
Fear of death mediates ostracism distress and the moderating role of attachment internal working models
Authors: Yaakobi Erez 
Published: August 2018

AbstractOstracism is known to cause psychological distress; however, it remains unclear why ostracism evokes this response. Two experiments tested empirically whether fear of death mediates ostracism effects and whether attachment internal working models moderate this role. A total of 288 participants played Cyberball with two other ostensible players. After the game the accessibility of their death‐related thoughts was assessed by a word completion task, and the Needs Satisfaction Scale was used to measure their distress. Participants’ attachment orientation was measured using the Experiences in Close Relationship scale. Death anxiety fully mediated ostracism distress. However, this effect was stronger in low‐anxiety individuals. These studies contribute to the ostracism literature by providing further empirical support that death anxiety mediates ostracism distress, and to the attachment literature by documenting the moderation effect of attachment anxiety.
3D Printed Adapter to Commercial Electronic Micropipettes for Electroanalysis Directly Inside Disposable Tips
Authors: Azevedo Gustavo Chevitarese , Quirino Welber Gianini , Matos Maria Auxiliadora Costa , Matos Renato Camargo 
Published: August 2018

AbstractThe aim of this paper was to design a low cost 3D printed adapter to commercial micropipette that allows a pipette tip to be used as an electrochemical cell, for measurements at a microelectrode. This device combine the advantages of microelectrodes, electronic micropipettes and disposable tips for direct electrochemical analysis. The 3D printed device was used as a proof of concept, to analyze the voltammetric behavior of ferrocene using gold microelectrode in N,N‐Dimethylformamide (DMF) by square wave voltammetry (SWV), showing good response in non‐aqueous medium. The developed adapter was also tested for modifying a gold electrode directly inside a pipette tip, using only 10 μL of modification solution, with further dopamine analysis. The developed methodology was applied for determining dopamine in tap water samples as a proof of principle. The system was evaluated for repeatability (RSD 4 %, n=50), and reproducibility (RSD 4 %), indicating good performance for the considered concentration level. The work developed shows the efficacy and reliability of the constructed device, applicable to electrochemical analysis both in aqueous or non‐aqueous media.
Massive parallel sequencing of short tandem repeats in the Korean population
Authors: Kim Se‐Yong , Lee Han‐Chul , Chung Ukhee , Ham Seon‐Kyu , Lee Ho Yeon , Park Su Jeong , Roh Ye Jee , Lee Seung Hwan 
Published: August 2018

AbstractSTR analysis using capillary electrophoresis has been the most widely used method for forensic DNA typing. Recently, massive parallel sequencing (MPS) technique has been emerging as an innovative tool to supplement or replace the conventional CE process. In this study, we evaluated the application of commercial MiSeqFGx™ forensic signature kit (Illumina Inc., San Diego, CA, USA) in the Korean population, including performance comparison with CE‐based STR profiling kits. The genotyping results of 209 unrelated random Korean individuals were summarized according to the International Society for Forensic Genetics guideline. The study revealed that 26 novel sequence variations in autosomal STR were newly found that had not been previously reported in other forensic literature. This indicates that MPS may be an effective supplementary tool for forensic DNA typing and the database to increase the discriminatory power of individual identification.
Earthquake response of a multiblock nuclear reactor graphite core: Experimental model vs simulations
Authors: Voyagaki Elia , Kloukinas Panos , Dietz Matt , Dihoru Luiza , Horseman Tony , Oddbjornsson Olafur , Crewe Adam J. , Taylor Colin A. , Steer Alan 
Published: August 2018

SummaryThe complex dynamics of a quarter‐scale model of a graphite nuclear reactor core, representative of the second generation of British advanced gas‐cooled nuclear reactors, is investigated numerically and experimentally. Advanced gas‐cooled nuclear reactor cores are polygonal, multilayer, arrays of graphite bricks, with each brick allowed to rock by design relative to each other in accordance with the boundary conditions. A 35 000 DOF, nonlinear finite element model of the core created by Atkins Nuclear, was analysed on a high performance computing facility at the University of Bristol, and a corresponding 8 t physical model, equipped with 3200 data acquisition channels, was built and tested on the University of Bristol 6‐DOF shaking table. In this paper, the two models are subjected to a series of (1) synthetic earthquake and (2) idealised harmonic input motions. The experimental data are used to compare and verify the two models and explore the dynamics of the core. A kinematic model of the response is also developed based solely on geometric constraints. The results are presented in the form of response maps and graphs. Important conclusions are drawn as to the dynamics and earthquake response of such systems, which inform numerical model validation. It is found that contrary to the case of a small number of rocking blocks that exhibit highly complex response patterns, the behaviour of the model at hand is both smooth and repeatable. An analogy between the response of the core and that of dense granular matter exhibiting particle interlocking and dilatancy is highlighted.
Enabling radioprotection capabilities in next generation wireless communication systems: An ecological green approach
Authors: Zarakovitis Charilaos C. , Ni Qiang , Kourtis Michail‐Alexandros 
Published: August 2018

AbstractIn future fifth‐generation and beyond radio systems, access points equipped with massive antennas will be deployed to support the increased communication demands. As a result, radio environments will become more dense and users will be exposed to higher electromagnetic field (EMF) radiation from wireless devices than today. This paper proposes to take preemptive action toward protecting the public health from potential EMF‐related ill effects by examining radiation‐aware solutions for future green wireless communication systems from the radio resource scheduling perspective. Our efforts focus on correlating the transmit power levels of the wireless system with the operands used to express the EMF dosimetry metrics known as maximum permissible exposure and specific absorption rate. In addition, we formulate power minimization problems subject to the maximum permissible exposure and specific absorption rate safety standards, and the individual user quality‐of‐service demands to derive convex optimization‐based solution of dynamic subcarrier allocation and adaptive power management. The simulation results confirm that our green solution reduces significantly the user exposure to radiation, while providing the required quality of service. We expect that our findings can kick off new research directions for controlling the public exposure to radiation from wireless devices in dense networks toward safer fifth‐generation communication systems.
Enzymatic catalysis for sustainable production of high omega‐3 triglyceride oil using imidazolium‐based ionic liquids
Authors: Fu Hong , Li Mengqi , Ni Ruimin , Lo Yangming Martin 
Published: August 2018

AbstractTwo different fish oil preparations, namely triglycerides and ethyl esters containing, respectively, 30.02% and 74.38% of omega‐3 fatty acids, were employed as the substrates for transesterification. Catalyzed by immobilized lipase using imidazolium‐based ionic liquid systems, the total content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the resulting triglyceride reached 63.60% when 4% hydrophobic ionic liquid was used, which was 11.74% higher than that of the triglyceride produced in a solvent‐free reaction system. The activation energy of the product (triglyceride‐type fish oil) was 173.64 KJ mol−1, which was not significantly different from that of the commercial ethyl ester‐type fish oil, so were the other thermal oxidative kinetic parameters. The kinetic parameters depicting the thermal and oxidative stability of the fish oil product provide the basis for industrial processing, storage, and applications.
Repeatability of language fMRI lateralization and localization metrics in brain tumor patients
Authors: Agarwal Shruti , Hua Jun , Sair Haris I. , Gujar Sachin , Bettegowda Chetan , Lu Hanzhang , Pillai Jay J. 
Published: August 2018

AbstractTo assess the within‐subject intra‐scan session repeatability of language functional MRI (fMRI) activation maps in patients with brain tumors who were undergoing presurgical fMRI as part of their preoperative clinical workup. Sentence completion (SC) and silent word generation (SWG) tasks were used for language localization and hemispheric lateralization for identifying the primary language cortex. Within‐subject repeatability for each of these paradigms was assessed in right‐handed patients—37 for SC and 78 for SWG. Repeatability of activation maps between consecutive runs of the same task within the same scan session was evaluated by comparing lateralization indexes in holohemispheric and regional language areas. Displacement of center of activation between consecutive runs was also used to assess the repeatability of activation maps. Holohemispheric and regional language lateralization results demonstrated high intra‐subject intra‐scan repeatability when lateralization indices were calculated using threshold‐dependent and threshold‐independent approaches. The high repeatability is demonstrated both when centers of mass of activation are considered within key eloquent regions of the brain, such as Broca's area and Wernicke's area, as well as in larger more inclusive expressive and receptive language regions. We examined two well‐known and widely accepted language tasks that are known to activate eloquent language cortex. We have demonstrated very high degree of repeatability at a single‐subject level within single scan sessions of language mapping in a large cohort of brain tumor patients undergoing presurgical fMRI across several years at our institution.
Altered neural signatures of interoception in multiple sclerosis
Authors: Salamone Paula C. , Esteves Sol , Sinay Vladimiro J. , García‐Cordero Indira , Abrevaya Sofía , Couto Blas , Adolfi Federico , Martorell Miguel , Petroni Agustín , Yoris Adrián , Torquati Kathya , Alifano Florencia , Legaz Agustina , Cassará Fátima P. , Bruno Diana , Kemp Andrew H. , Herrera Eduar , García Adolfo M. , Ibáñez Agustín , Sedeño Lucas 
Published: August 2018

AbstractMultiple sclerosis (MS) patients present several alterations related to sensing of bodily signals. However, no specific neurocognitive impairment has yet been proposed as a core deficit underlying such symptoms. We aimed to determine whether MS patients present changes in interoception—that is, the monitoring of autonomic bodily information—a process that might be related to various bodily dysfunctions. We performed two studies in 34 relapsing–remitting, early‐stage MS patients and 46 controls matched for gender, age, and education. In Study 1, we evaluated the heartbeat‐evoked potential (HEP), a cortical signature of interoception, via a 128‐channel EEG system during a heartbeat detection task including an exteroceptive and an interoceptive condition. Then, we obtained whole‐brain MRI recordings. In Study 2, participants underwent fMRI recordings during two resting‐state conditions: mind wandering and interoception. In Study 1, controls exhibited greater HEP modulation during the interoceptive condition than the exteroceptive one, but no systematic differences between conditions emerged in MS patients. Patients presented atrophy in the left insula, the posterior part of the right insula, and the right anterior cingulate cortex, with abnormal associations between neurophysiological and neuroanatomical patterns. In Study 2, controls showed higher functional connectivity and degree for the interoceptive state compared with mind wandering; however, this pattern was absent in patients, who nonetheless presented greater connectivity and degree than controls during mind wandering. MS patients were characterized by atypical multimodal brain signatures of interoception. This finding opens a new agenda to examine the role of inner‐signal monitoring in the body symptomatology of MS.
Siltuximab in relapsed/refractory multicentric Castleman disease: Experience of the Italian NPP program
Authors: Tonialini Lorenzo , Bonfichi Maurizio , Ferrero Simone , Malipiero Giacomo , Nozza Andrea , Argnani Lisa , Zinzani Pier Luigi 
Published: August 2018

AbstractBecause of the rarity of the disease, randomized clinical trials for multicentric Castleman disease (MCD) remain a challenge and, as a consequence, there is no established standard of care. Siltuximab is a chimeric immunoglobulin G1κ monoclonal antibody against human IL‐6 which was recently approved by FDA. Eligible patients in Italy were granted early access through a Named Patient Program (NPP). The aim of this observational multicenter retrospective study was to analyze outcomes and toxicity data of relapsed or refractory MCD patients treated with siltuximab in a real life context. All the 9 patients who received siltuximab in Italy under the NPP were enrolled. Median duration of treatment was 285 days (range, 104‐1113 days). The global overall response rate was 33.3%. At the time of this analysis, none of the 3 responder patients had subsequently disease relapse: response duration was 20, 23, and 37 months, respectively. Grade 1 to 2 fatigue and pruritus were observed in 2 (22.2%) patients, and weight gain was reported in only 1 patient (grade 1); local edema was reported in 2 patients with a grade 2 presentation. The most common side effect was upper respiratory tract infection reported in 3 (33.3%) patients but in these cases was grades 1 to 2. No patient developed an infusion‐related reaction. Our NPP data support siltuximab as single agent in the real‐life experience of the treatment of relapse/refractory MCD patients in effectiveness, safety profile, and sustained disease control.
Precision immunotherapy, mutational landscape, and emerging tools to optimize clinical outcomes in patients with classical myeloproliferative neoplasms
Authors: Mughal Tariq I. , Lion Thomas , Abdel‐Wahab Omar , Mesa Ruben , Scherber Robyn M. , Perrotti Danilo , Mauro Michael , Verstovsek Srdan , Saglio Giuseppe , Van Etten Richard A. , Kralovics Robert 
Published: August 2018

AbstractFollowing the 47th American Society of Hematology Meeting in 2005, the late John Goldman and Tariq Mughal commenced a conference, the 1st Post‐ASH Workshop, which brought together clinicians and scientists, to accelerate the adoption of new therapies for patients with myeloproliferative neoplasms (MPNs). The concept began with recognition of the CML success story following imatinib therapy, the discovery of JAK2V617F, and the demonstration that BCR‐ABL1‐negative MPNs are driven by abnormal JAK2 activation. This review is based on the presentations and deliberations at the XIIth Post‐ASH Workshop on BCR‐ABL1 positive and negative MPNs that took place on December 12 to 13, 2017, in Atlanta, Georgia, immediately following the 59th American Society of Hematology Meeting. We have selected some of the translational research and clinical topics, rather than an account of the proceedings. We discuss the role of immunotherapy in MPNs and the impact of the mutational landscape on TKI treatment in CML. We also consider how we might reduce TKI cardiovascular side effects, the potential role of nutrition as adjunctive nonpharmacologic intervention to reduce chronic inflammation in MPNs, and novel investigational therapies for MPNs.
Change from health center to family physician period in the Turkish health system: A qualitative study
Authors: Cevik Celalettin , Kilic Bulent 
Published: August 2018

SummaryIntroductionHealth care reforms in Turkey have been implemented resolutely in the last 12 years. The shift from health center (HC) to a family physician (FP) approach is 1 of the basic interventions of these reforms. The goal of the current study is to evaluate opinions of patients, health care workers, and managers, using qualitative methods.MethodsIn‐depth interviews were conducted with patients who received health care services in both the FP and the HC periods, and with health care workers and managers in health care facilities that served in both periods. The interviews were recorded after obtaining permission, and then transcribed. Both health care staff that worked in the 2 periods and the patients that received health care services in the 2 periods reported that FP system was superior to HC system in attention showed by the family physicians, being followed by the same physician, and having confidence in physicians.ResultsThe current FP period is superior to HC in facilities such as patient records, computer, internet, and phone. The strengths of HC period include home visits, environmental health studies, and family planning services. According to health care workers who worked in the 2 periods, HC was superior to FP in team spirit, public service delivery, and surveillance of communicable diseases.ConclusionPublic service delivery and environmental health studies and primary care practice in rural areas must be scrutinized in the context of the FP approach.
Choosing cooperation over competition; hospital strategies in response to selective contracting
Authors: van Ineveld Martin , van Wijngaarden Jeroen , Scholten Gerard 
Published: August 2018

SummaryWith the introduction of market competition in health care, the Dutch government enabled health insurers to contract hospital care selectively. The assumption is that “selective contracting” will stimulate efficiency, effectiveness, and innovation and will diminish overcapacity. In 2010, the first Dutch health insurers started experimenting with “selective contracting” by setting a minimum treatment volume per year for complex treatments. In an explorative, multiple case study among 15 hospitals in five regions, we found that instead of competing, hospitals started to cooperate and strengthen their networks. The government intended to remove redundant hospital capacity and improve quality by stimulating specialization and concentration. Our study showed that specialization was indeed stimulated, which may have increased quality of care. However, facilitated by the absence of a countervailing power (government or insurer), hospitals in our cases negotiated to the effect of preserving hospital capacity. Within the current political debate between supporters of competition and advocates of a national health service, the importance and role of the (medical) networks should be taken into account. Otherwise, the outcomes of health care governance will be different than intended by either party.
Operation of two major reservoirs of Iran under IPCC scenarios during the XXI century
Authors: Akbari‐Alashti Habib , Soncini Andrea , Dinpashoh Yagob , Fakheri‐Fard Ahmad , Talatahari Siamak , Bocchiola Daniele 
Published: August 2018

AbstractWe assess the effects of prospective climate change until 2100 on water management of two major reservoirs of Iran, namely, Dez (3.34 × 109 m3) and Alavian (6 × 107 m3). We tune the Poly‐Hydro model suited for simulation of hydrological cycle in high altitude snow‐fed catchments. We assess optimal operation rules (ORs) for the reservoirs using three algorithms under dynamic and static operation and linear and non‐linear decision rules during control run (1990–2010 for Dez and 2000–2010 for Alavian). We use projected climate scenarios (plus statistical downscaling) from three general circulation models, EC‐Earth, CCSM4, and ECHAM6, and three emission scenarios, or representative concentration pathways (RCPs), RCP2.6, RCP4.5, and RCP8.5, for a grand total of nine scenarios, to mimic evolution of the hydrological cycle under future climate until 2100. We subsequently test the ORs under the future hydrological scenarios (at half century and end of century) and the need for reoptimization. Poly‐Hydro model when benchmarked against historical data well mimics the hydrological budget of both catchments, including the main processes of evapotranspiration and streamflows. Teaching–learning‐based optimization delivers the best performance in both reservoirs according to objective scores and is used for future operation. Our projections in Dez catchment depict decreased precipitation along the XXI century, with −1% on average (of the nine scenarios) at half century and −6% at the end of century, with changes in streamflows on average −7% yearly and −13% yearly, respectively. In Alavian, precipitation would decrease by −10% on average at half century and −13% at the end of century, with streamflows −14% yearly and −18% yearly, respectively. Under the projected future hydrology, reservoirs' operation would provide lower performance (i.e., larger lack of water) than now, especially for Alavian dam. Our results provide evidence of potentially decreasing water availability and less effective water management in water stressed areas like Northern Iran here during this century.