bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translating Research to Practice Using a Team-Based Approach to Cancer Rehabilitation: A Physical Therapy and Exercise-Based Cancer Rehabilitation Program Reduces Fatigue and Improves Aerobic Capacity
Authors: Leach Heather J. , Covington Kelley R. , Pergolotti Mackenzi , Sharp Julia , Maynard Brooke , Eagan Jeffrey , Beasley Joanne 
Published: July 2018

Background and Objective:
Intervention research has shown that exercise-based rehabilitation is safe and effective for reducing disease burden across the cancer continuum. However, the translation of this research to programs implemented in health care settings remains a challenge. This study describes the implementation of a physical therapy–based exercise program for patients who have been diagnosed with cancer and its effectiveness for reducing fatigue and improving aerobic capacity.

Methods:
Retrospective analysis of a single-group, pre/postprogram assessment for adult patients who have been diagnosed with cancer (N = 546). Six-Minute Walk Test (6MWT) measured aerobic capacity. Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT-Fatigue) and Piper Fatigue Scale (PFS) measured fatigue. Paired-samples t tests examined changes in outcomes from pre- to postprogram assessments. Linear regression explored predictors of postprogram outcomes.

Results:
Participants were 63.7 ± 12.2 years old, diagnosed with breast (27.1%), hematological (15.4%), head and neck (12.6%), lung (12.3%), prostate (11%), colorectal (7.3%), or other (14.3%) cancers. For those who completed the postprogram measures (N = 169), FACIT-Fatigue scores improved (MΔ = +8.42 ± 9.2, t
79 = −8.21, P = .000), PFS scores improved (MΔ = −2.1 ± 2.0, t
81 = 9.5, P = .000), and 6MWT distance improved (MΔ = +42.9 ± 53.8 m, t
160 = −10.1, P = .000). Age (P = .034) and time since completing chemotherapy (P = .000) or radiation therapy (P = .014) was inversely associated with the 6MWT. Greater exercise session attendance was associated with higher PFS scores (P = .020).

Limitations:
Only 31% of participants completed postprogram assessments, and limited information was available regarding reasons for dropout/withdrawal.

Conclusions:
This study provides a real-world example of a cancer rehabilitation program implemented in a health care setting, which was successful in reducing fatigue and improving aerobic capacity.
Oncology Section EDGE Task Force on Cancer: Measures of Cancer-Related Fatigue—A Systematic Review
Authors: Fisher Mary Insana , Davies Claire , Lacy Hannah , Doherty Deborah 
Published: July 2018

Background:
Cancer-related fatigue (CRF) is one of the most common side effects of cancer and cancer treatment. Being able to accurately screen for and assess CRF will improve access to and prescriptions for interventions. Valid and reliable measures to screen for and assess CRF need to be identified.

Purpose:
To identify and recommend reliable, valid, and clinically useful tools to screen for and assess CRF among those treated for cancer.

Methods:
A systematic review of the literature was conducted to assess the published psychometric properties and clinical feasibility of each method identified. Task force members independently reviewed each measure using the Cancer EDGE Rating Form.

Results:
Review of 136 studies resulted in recommendations for 14 questionnaires. Five unidimensional and 9 multidimensional questionnaires are recommended by the Oncology EDGE Task Force.

Conclusion:
The 10-point Numeric Rating Scale for Fatigue is best as a screening tool, whereas the Multidimensional Fatigue Symptom Inventory is a highly recommended multidimensional tool. Ease of screening can promote referral for interventions, whereas thorough assessment drives appropriate interventions.
Physical and Edema Therapy Management of Amyloidosis in the Acute Care Setting: A Case Report
Authors: Boudreau Jennifer , Lagunilla Jane , Kotkiewicz Jean 
Published: July 2018

Background and Purpose:
Currently, there are no formal guidelines describing rehabilitation interventions for those with amyloidosis. This case report explores the application of physical and edema therapy interventions, including external compression, for a patient with a diagnosis of light-chain (AL) amyloidosis and functionally limiting orthostatic hypotension in the acute care setting.

Case Description:
A 52-year-old man with a diagnosis of immunoglobulin AL amyloidosis presented to the acute care setting with progressed orthostatic hypotension, bilateral lower extremity edema, and episodes of syncope. The patient spent 17 days in the inpatient setting and received physical therapy (PT) and edema therapy through the inpatient lymphedema service. Rehabilitation focused on exercise, compression, and behavioral and educational interventions over the course of 9 PT sessions and 7 edema therapy sessions.

Outcomes:
Before interventions, the patient was unable to safely ambulate at home due to syncope. He progressed to being able to ambulate 1560 ft with seated rests. The patient demonstrated decreased limb circumferential measurements, improved performance on the 6-Minute Walk Test, improved ability to self-manage orthostatic hypotension and edema, and increased participation in activities of daily living.

Discussion:
The combination of physical and edema therapy services may have compensated for orthostatic hypotension and improved standing tolerance. The patient's blood urea nitrogen and brain natriuretic peptide levels may have improved because of the application of external compression. Overall, the patient experienced decreased limb size, increased exercise tolerance, decreased syncopal episodes, and improved quality of life without changes in pharmacologic management or adverse events.
Emotional Influences on Cognitive Processing in Fibromyalgia Patients With Different Depression Levels
Authors: Sitges Carolina , González-Roldán Ana M. , Duschek Stefan , Montoya Pedro 
Published: July 2018

Objectives:
Comorbid symptoms in fibromyalgia (FM) syndrome, such as mood disorders and cognitive dysfunction, may lead to greater functional impairment than pain itself. This study aimed to unravel the modulating role of depression in response execution and inhibition in FM using an emotional go/no-go task.

Materials and Methods:
In total, 17 FM patients with low depression, 18 FM patients with high depression, and 18 pain-free controls were included. Pain, happy, and neutral faces were pseudorandomly presented, and participants were asked to respond to male faces (go trials) by pressing a button, and to inhibit their responses if female faces were presented (no-go trials).

Results:
FM patients with high depression showed lower positive affect scores, higher negative affect and pain vigilance scores, and slower reaction times, than FM patients with low depression and pain-free controls. Both subgroups of FM patients also rated pain faces as more arousing than pain-free controls. The lack of group differences in our electrophysiological data, neither in N200 nor in P300 amplitudes, seems to indicate that there was no significant impairment in response execution in response inhibition due to pain.

Discussion:
Taken together, these results add evidence to the notion that depression is associated with higher affective dysregulation and deficit of information-processing speed in FM. Furthermore, our data suggest that pain induces a bias to pain-related information, but the absence of significant group differences in event-related potential amplitudes, calculated with analyses of covariance (ANCOVA) (with pain intensity), seem to show that pain intensity is not a predictor for cognitive dysfunctions.
Arthroscopic Elbow Contracture Release in the Pediatric Patient
Authors: Andelman Steven M. , Walsh Amanda L. , Sochol Kristen M. , Rubenstein William M. , Hausman Michael R. 
Published: July 2018

Background:
Elbow contracture is a sequelae of elbow trauma in pediatric patients. Arthroscopic contracture release has been shown to provide equivalent results to open contracture release with less associated morbidity and complications in the adult population. However, open contracture release is still commonly utilized in pediatric patients. The goal of this study is to determine the clinical results and safety profile of arthroscopic elbow contracture release in the pediatric population.

Methods:
A retrospective review of all patients 18 years of age and younger who underwent arthroscopic elbow contracture release was performed. Demographic statistics, indication for surgery, preoperative and postoperative flexion-extension and pronation-supination range of motion, and all complications were recorded and analyzed.

Results:
Twenty-five patients were identified as having undergone 29 arthroscopic elbow contracture releases. The most common index injury was elbow contracture after radial head fracture. The flexion-extension arc of motion improved from 93.0±39.9 degrees to 128.0±19.2 degrees for a total improvement of 35.2 degrees (P=0.0002), whereas the pronation-supination arc of motion improved from 141.0±58.6 degrees to 153±49.3 degrees for a total improvement of 12.2 degrees (P=0.097). There were 7 total complications.

Conclusions:
Arthroscopic elbow contracture release allows for restoration of range of motion with an acceptable safety profile and can be considered as a less invasive alternative to open contracture release in the pediatric population.

Level of Evidence:
Level IV.
Dynamic Angiogenic Switch as Predictor of Response to Chemotherapy-Bevacizumab in Patients With Metastatic Colorectal Cancer
Authors: Cubillo Antonio , Álvarez-Gallego Rafael , Muñoz Manuel , Pond Gregory , Perea Sofía , Sánchez Gema , Martin María , Rodríguez-Pascual Jesús , Garralda Elena , Vega Estela , de Vicente Emilio , Quijano Yolanda , Muñoz César , Ugidos Lisardo , Toledo Rodrigo A. , Hidalgo Manuel 
Published: July 2018

Background:
Previous studies have shown that metastatic colorectal carcinoma (mCRC) patients treated with bevacizumab, experience variation in the plasma levels of angiogenesis growth factors and related cytokines, called angiogenic switch (AS). The aim of the present study was to analyze the relationship between AS and the clinical response during standard chemotherapy-bevacizumab treatment.

Patients and Methods:
Patients with Eastern Cooperative Oncology Group 0-1 mCRC were eligible. Patients received treatment with standard dose capecitabine plus either oxaliplatin or irinotecan and bevacizumab for 6 cycles. Initial treatment was followed by maintenance therapy with bevacizumab plus capecitabine until progression. Plasma levels of angiogenic-related cytokines (hepatocyte growth factor, placental growth factor, macrophage chemoattractant protein-3, MM-9, eotaxin, basic fibroblast growth factor, and interleukin 18) were prospectively analyzed at baseline and every 8 weeks. Progression-free survival (PFS) was calculated using the Kaplan-Meier method.

Results:
A total of 71 patients were enrolled. AS was observed in 45 patients (63.4%), 28 of whom experienced AS at the first evaluation after treatment start. Disease control, which includes partial/complete response and stable disease, was seen in 96% of AS patients (43/45), but only in 15/26 (58%) for the remaining patients without evidence of AS (P<0.001). The median PFS of AS patients was 11.4 months (95% confidence interval, 8.6-15.8) versus 8.3 months for patients without AS (95% confidence interval, 5.6-16.4; P=0.04).

Conclusions:
Chemotherapy plus Bevacizumab combination in mCRC patients results in dynamic changes in plasma cytokines, which is associated with better disease control and longer PFS. These new findings support continuing studying AS as a potential marker of angiogenesis inhibitor effectiveness.
Time Course of Exercise Training–Induced Muscle Strength Changes in Type 2 Diabetes
Authors: Mathis Ruth Ann , Taylor J. David , Fletcher James P. , Rainey Jacquie , Cade W. Todd , Bandy William D. 
Published: July 2018

Purpose:
To investigate longitudinal muscle strength changes in response to exercise training in people with type 2 diabetes.

Methods:
Twenty-one people with type 2 diabetes were randomly allocated to either a moderate or high-intensity exercise training group with the only difference between the groups being the prescribed exercise training intensity. Muscle strength (8 repetition maximum in kilograms) was measured weekly for 12 weeks using the chest press, leg press, row, and knee extension exercises. Muscle strength was expressed as the sum of 8 repetition maximum scores for each exercise.

Results:
Linear mixed models indicated significant gains in muscle strength (P < .001) in both groups and no significant difference in gains in muscle strength (P = .47) between the groups. Pooled data from both groups indicated significant improvement in muscle strength (P < .05) week-to-week beginning after week 1 and continued until week 9.

Conclusion:
Participation in either a moderate or high-intensity exercise training program can result in similar gains in muscle strength for people with type 2 diabetes. Muscle strength improvements can occur on a weekly basis for the first 8 weeks of exercise training, with a plateau in gains occurring at week 9 through week 12.
Objective Improvement in Daily Physical Activity in Heart Failure Remains Elusive: A Systematic Review
Authors: Shoemaker Michael J. , Tresh Thomas , Hart Jack , Wood Tiffany 
Published: July 2018

Purpose:
The purpose was to comprehensively review the literature for exercise- and psychosocial-based rehabilitation interventions for improving daily physical activity (PA) in patients with heart failure (HF).

Methods:
A search of the PubMed/MEDLINE, CINAHL, ProQuest Medical, PsycINFO, and Web of Science databases was conducted. Articles were included if they (1) were written in English, (2) included subjects with HF, (3) assessed physical or psychosocial rehabilitation interventions to improve daily PA, and (4) measured daily PA qualitatively or quantitatively. Case reports, non–peer-reviewed research, and articles without full text available were excluded. Two authors completed the screening independently, and conflicts were resolved by a third author.

Results:
One thousand four hundred sixty-two unique records were identified, and of these, 47 were selected for full-text review. Ultimately 15 were included: 13 randomized controlled trials and 2 case series, published from 1999 to 2016. No studies using only exercise interventions resulted in objective increases in daily PA. All 3 studies using only psychosocial interventions resulted in an increase, but only 1 of these used an objective measure and that study was a case series. One study using a combination of exercise and psychosocial interventions showed an objective increase in daily PA, but that result was not replicated later in a similar study.

Conclusions:
Exercise interventions alone do not result in improvement in daily PA in patients with HF. Further investigation concerning psychosocial interventions, with objective outcome measurement, is warranted.
Fitness Fatness Index and Residual-Specific Mortality
Authors: Frith Emily , Loprinzi Paul D. 
Published: July 2018

Purpose:
A fitness fatness index (FFI) was recently (2016) developed, with FFI calculated as cardiorespiratory fitness divided by waist-to-height ratio. This FFI algorithm includes easily-assessed patient health parameters that physical therapists can readily determine. Residual-specific mortality (deaths not from the 9 major causes) is more prevalent than each of the 9 major causes of death. No study has evaluated the association of FFI on residual mortality risk, which was this study's purpose.

Methods:
Data from the 1999 to 2006 National Health and Nutrition Examination Survey were used, with follow-up through 2011. Among the 9974 participants, 162 died of residual mortality over the follow-up period; median follow-up period was 105 months (interquartile range: 81–129).

Results:
In a Cox proportional hazard model, for every 1 FFI increase, participants had a 9% reduced hazard of residual-specific death (hazard ratio = 0.91; 95% confidence interval: 0.87–0.95; P < .001).

Conclusions:
This novel study presents evidence of an inverse association between FFI on residual-specific mortality. Physical therapists can use this algorithm to further assess their patient's current and future health status.
Description and Comparison of Preseason and Postseason Blood Pressure Measures Among Collegiate Athletes: A Prospective Observational Study
Authors: Arena Sara , LaBelle Lauren , Larsen Jennifer , Palomino Lia , Hew-Butler Tamara , Peterson Edward 
Published: July 2018

Purpose:
Growing evidence suggests that suboptimal blood pressure (BP) measures among professional athletes parallel rates among nonathletes; however, BP measures among collegiate athletes of varied sports or the relationship of this measure to body mass index (BMI) has not been reported. The primary purpose of this study is to describe and compare preseason and postseason BP measures among collegiate athletes of varied sports and sexes. A secondary purpose is to describe correlations between a BP measurement and BMI during the course of a competitive season.

Methods:
A prospective observational study using a sample of convenience assessed resting BP and BMI of athletes from men's soccer, cross country, and swimming; and women's volleyball, cross country, and swimming at one Division I university. Blood pressure measures were further classified as elevated, stage 1, or stage 2 hypertensive (HTN) using previously established criteria. Descriptive statistics reported athlete demographics, BP, and BMI. A pairwise t test compared and determined differences in preseason and postseason BP. Correlations of BP with BMI were examined. Statistical significance was set at P ≤ .05.

Results:
Seventy-four athletes met preseason and postseason inclusion criteria. Preseason and postseason right-sided BP assessment identified 10.8% (n = 8), 5.4% (n = 4), and 1.3% (n = 1) and then 17.6% (n = 13), 17.6% (n = 13), and 1.3% (n = 1) athletes to have Elevated, stage 1 HTN, and stage 2 HTN measures, respectively. All BP measures demonstrated significant preseason to postseason increases (P = .001) in all sports with significantly higher BP increases in men compared with women. Furthermore, positive correlations between systolic BP and BMI were identified.

Conclusions:
Elevated and HTN BP measures were identified among collegiate athletes. Although significant increases in BP over time were detected, causative factors warrant further examination; however, increase in BMI may be a contributing factor. Findings of this study support routine BP assessment by physical therapists serving the collegiate athlete population.
Association between metabolic profiles in urine and bone mineral density of pre- and postmenopausal Chinese women
Authors: Yu Lisha , Qi Huanhuan , An Guohua , Bao Jun , Ma Bo , Zhu Jianwei , Ouyang Gang , Zhang Pengling , Fan Hongwei , Zhang Qi 
Published: July 2018

Abstract

Objective:
In the present study, we aimed to characterize the pathological development of menopausal osteoporosis, as well as to explore potential biomarkers and metabolic pathways involved in osteoporosis.

Methods:
Urine samples from 322 female participants categorized by menopause status and different bone conditions were collected and analyzed based on a gas chromatography–mass spectrometry (GC–MS) approach. Multivariate and univariate statistical analyses were carried out for urinary metabolomic profile characterization and comparison.

Results:
Seventeen metabolites in the low bone mineral density (BMD) groups were clearly differentiated from those in normal BMD groups. Among these 17 differentiating metabolites, taurine, β-alanine, and 5-hydroxycaproic acid were found to be potential biomarkers of osteoporosis. The taurine metabolic pathway and the β-alanine metabolic pathway were found to be related to menopause and bone loss.

Conclusions:
Based on the GC–MS metabolomic platform, four typical pathological phases during the progression of postmenopausal osteoporosis were described. Several differentiating metabolites and metabolic pathways were found to be closely related to the pathology of postmenopausal osteoporosis. Our results provided a solid foundation for further studies on early diagnosis and pathomechanistic evaluation.
Difference in carotid intima-media thickness between pre and postmenopausal women
Authors: Ieamtairat Piyamas , Soontrapa Sukree , Kaewrudee Srinaree , Promsorn Julaluck , Takong Wittawat , Somboonporn Woraluk 
Published: July 2018

AbstractObjectives:To examine whether carotid intima-media thickness (CIMT), the prevalence of increased CIMT, and the presence of carotid plaque differ according to menopausal status.Methods:In this analytical cross-sectional study, we enrolled 61 premenopausal women and 61 postmenopausal women. We matched the two groups for age. Participants were classified as either premenopausal or postmenopausal according to menstrual history and follicular-stimulating hormone level. Two skilled radiologists measured CIMT and carotid plaque in all participants by using B-mode ultrasound.Results:The mean age was 49.25 ± 2.0 years. The mean number of years since menopause in the postmenopausal group was 1.9 ± 0.92 years. After adjusted analysis, the mean CIMT of the common carotid artery of postmenopausal women was significantly higher than that of premenopausal women, with a mean difference of 0.068 mm (95% confidence interval 0.023, 0.113). There was no significant association between number of years since menopause and mean CIMT. Although the prevalence of increased CIMT and the presence of carotid plaque were significantly higher in the postmenopausal group than in the premenopausal group according to crude analysis, this difference was not statistically significant after adjusted analysis. Multiple linear regression analysis for assessing potential risk factors for the alteration of mean CIMT showed that only menopausal status and body mass index were independently associated factors.Conclusions:Our findings indicate that postmenopausal status is a significant factor of high mean CIMT. These findings add to the growing evidence showing that menopause transition is a critical period for subclinical atherosclerosis development.