bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetic changes produced in women victims of intimate partner violence: A systematic review
Authors: González-Martínez Coral , Haarkötter Christian , Carnero-Montoro Elena , Lorente Jose A , Lorente Miguel 
Published: November 2024

Background: Intimate partner violence (IPV) is a prevalent form of violence against women that encompasses physical, sexual, and emotional abuse, as well as controlling behaviors by intimate partners, and predisposes the victims to multiple diseases. Objective: This systematic review aims to identify epigenetic marks associated with IPV and the resultant stress experienced by victims. Design: This study is a systematic review conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 guidelines. The review includes a comprehensive search and analysis of relevant literature to identify epigenetic changes associated with IPV. Data Sources and Methods: A systematic search was conducted across four databases: PubMed, Scopus, Web of Science, and ProQuest, using keywords related to IPV and epigenetics. The inclusion criteria were studies published in scientific journals with an experimental approach, focused on female survivors of gender-based violence, and providing information on epigenetic changes. The review included studies published up to June 15, 2024, with no time limits imposed, focusing on female victims of IPV. The inclusion criteria were studies published in scientific journals with an experimental approach, focused on female survivors of gender-based violence, and providing information on epigenetic changes. Results: The results revealed that epigenetic changes associated with IPV predominantly affect genes related to the glucocorticoid receptor, insulin-like growth factors, BDNF, and CPLX genes. These observations suggest that IPV is linked to significant epigenetic modifications in both victims and their offspring. Conclusion: It is concluded that IPV is associated with epigenetic changes both in the woman and in her offspring. These findings underscore the importance of understanding the biological embedding of IPV through epigenetic research to better address the long-term health consequences for women. However, more studies are necessary to validate these results.
Completion of the maternal continuity of care and associated factors among women who gave birth in the last 6 months in Kena District, southern Ethiopia: A community-based cross-sectional study, 2023
Authors: Haile Addisalem , Endashaw Gesila , Tekalign Tiwabwork , Kibe Kinde , Moga Fikre , Kebede Fekadu Abera , Adisu Aklilu 
Published: November 2024

Background: The maternity continuum of care includes attending at least four antenatal care (ANC) visits, delivering in a health facility, and receiving postnatal care. However, in many developing nations, including Ethiopia, completion of this continuum is low, contributing to high maternal mortality. So far, no studies have assessed this issue in the study area. Objective: To assess the completion of maternity continuum of care and associated factors among women who gave birth in the last 6 months in Kena district, southern, Ethiopia, 2023. Design: Cross-sectional study using quantitative data collection method. Methods: The study was conducted among 592 women in southern Ethiopia from April to June 2023. A study participants were selected by a simple random sampling technique. Data were collected using a structured, pretested, interviewer-administered questionnaire. Then, data were entered into EpiData 3.1 and analyzed using statistical package for social science software (SPSS version 26). Logistic regression was used to identify factors related to the maternity continuum of care, with statistical significance set at p < 0.05. Results: The mean age of the enrolled women was 28.78 ± 4.6 years. Of these, 11.8% (95% confidence interval (CI): 9%–14%) of women completed the entire maternity continuum care. Women with secondary education and above (adjusted odds ratio (AOR) = 5, 95% CI: 2.5–11), autonomy in healthcare decision-making (AOR = 2.4, 95% CI: 1.3–4.6), having information on maternal health (AOR = 2.4, 95% CI: 1.3–4.6) Early initiation of ANC (AOR = 4, 95% CI: 2.27–7.1) and birth preparedness (AOR = 2.7, 95% CI: 1.5–5) were significantly associated with completion. Conclusions: Completion of the maternity continuum of care in study area is very low. Targeted interventions should promote women’s autonomy in healthcare decision-making, early ANC initiation, and birth preparedness to improve outcomes.
Changes in self-rated health, quality of life, and psychological flexibility among adults with overweight over a 24-month acceptance and commitment therapy–based lifestyle intervention
Authors: Petäjä Mari , Lappalainen Raimo , Kettunen Tarja , Lappalainen Päivi , Kaipainen Kirsikka , Muotka Joona , Kasila Kirsti 
Published: November 2024

This study investigated the impact of online psychological flexibility training and support provided by peers on self-rated health (SRH) and health-related quality of life (HRQoL) among adults with overweight. It was a secondary analysis of a single-arm multi-center intervention study that was conducted in a real-life context. In a 2-years acceptance and commitment therapy (ACT) lifestyle intervention, participants ( N = 177) engaged in online ACT activities while receiving support from trained peers. Participants completed surveys at baseline, 6, 12, and 24 months. The research data were analyzed with structural equation modelling. At baseline, the participants with high SRH ( n = 83) had higher psychological flexibility and HRQoL than did participants with low SRH ( n = 94). At 24 months, the participants with low SRH at baseline reported increases in SRH, vitality and depression dimensions of HRQoL, and psychological flexibility. Increased psychological flexibility was associated with improved SRH.
Analysis of the influencing factors and spatiotemporal evolution characteristics of telemedicine service supply: Empirical evidence from pilot cities in China
Authors: Xueyu Zhang , Huawei Tan , Yingchun Chen 
Published: November 2024

Background Telemedicine is one of the major trends in the evolution of modern medicine. Telemedicine encompasses a wide range of services with different characteristics. Healthcare organisations know limited information on developing and utilising different types of telemedicine service programmes as well as factors and spatial and temporal characteristics that influence their development. Objective To analyse the factors influencing the development of telemedicine, and to explore the priority order of different telemedicine services carried out by healthcare institutions, as well as the spatiotemporal evolution characteristics. Methods This study selected Zunyi City, a national pilot city for telemedicine in China, and employed multinomial logistic regression to analyse factors influencing the provision of different types of telemedicine service programmes by healthcare institutions and evaluate the spatial and temporal evolutionary characteristics of spatially visualised telemedicine service programmes. Results When the price of services increased, providers were more inclined to conduct teleconsultation (OR: 1.023) and telepathology (OR: 1.058) than tele-imaging, and the willingness to conduct telecardiology (OR: 0.775) and telemetry (OR: 0.997) was relatively low. Patients’ out-of-pocket payments increased, and providers’ willingness to conduct teleconsultations (OR: 49.401) and telepathology (OR: 5.039) increased. Healthcare organisations at higher level were more willing to carry out teleconsultation (OR: 14.052), telepathology (OR: 8.071) and telemetry (OR: 13.113). Compared with private hospitals, public hospitals were 17.760, 12.248 and 87.860 times more likely to conduct teleconsultations, telecardiology and telepathology than tele-imaging. The effectiveness of telemedicine development may be related to the level of local economic development. Conclusion Medical institutions carry out telemedicine service programmes with a certain order of priority. Their decisions are often influenced by various factors such as price, out-of-pocket payment ratio and level and attribute of the healthcare organisation. The development of telemedicine may follow an inverted ‘U’ pattern with the level of regional economic development.
Language Learning Opportunities Abroad and International Student Mobility to China
Authors: Lyu Jingjing , Huang Yue 
Published: November 2024

This paper empirically investigates whether Chinese language learning opportunities abroad have exerted a positive effect on international student mobility (ISM) to China. We utilize both official and self-compiled panel data for 182 countries, spanning a period of 15 years. We use the establishment of Confucius Institutes as an indicator of Chinese language learning opportunities. As our benchmark regressions, we employ fixed effects models with both linear and nonlinear regressors. Our findings provide support for a significant positive impact of language learning opportunities on ISM, with evidence suggesting a diminishing marginal effect. This result is seldom documented in the existing literature. We verify the robustness of our findings in three ways. First, we assess whether the number of international students changes significantly before the exposure to Chinese language learning opportunities. Next, we examine if our main findings remain consistent when controlling for region-specific trends. Finally, we test the robustness of our main results against various changes in the estimation sample. We also find evidence of effect heterogeneity based on countries’ geographic distance to China, the linguistic distance from their official language to Chinese, and their income levels. This paper argues that exposure to the destination country’s language and culture is a critical determinant of students’ decisions to study abroad in that country. JEL Classification: F22, I20, N30.
Executive Summary of a Regional Meeting to Accelerate Oral Health Policies in the WHO African Region
Authors: Mutave R. , Muange P. , Carrasco-Labra A. , Urquhart O. , Bhosale A.S. , Makino Y. , Okeibunor J.C. , Glick M. 
Published: November 2024

Oral health is integral to general health and supports individuals in participating in society and achieving their potential. Yet, oral diseases are among the most common noncommunicable diseases (NCDs) in the World Health Organization (WHO) African region. The WHO African Regional Oral Health Strategy and the WHO Global Strategy on Oral Health were endorsed in 2016 and 2022, respectively, to address the current alarming situation by integrating oral diseases as part of NCDs toward universal health coverage (UHC). Both strategies highlighted the importance of research, especially the necessity to create and continuously update context- and needs-specific research; however, there is a paucity of information regarding research supporting evidence-informed oral health policies in the region. In this context, the University of Pennsylvania, African universities led by the University of Nairobi, and the WHO Regional Office for Africa initiated an “Evidence to Policy” project. This project consists of 3 phases: (1) preparation: stakeholder analysis; (2) co-creation: online needs assessment survey with oral health academia in the region and 2 scoping literature reviews to identify oral health research and barriers and facilitators for the development, dissemination, implementation, monitoring, and evaluation of oral health policies; and (3) validation: sharing findings from phase 2 through the stakeholder meetings. This executive summary presents the results of phase 3, the stakeholder in-person meeting held in November 2023 in Nairobi, Kenya. About 70 participants, including oral health educators and representatives from the Ministry of Health and WHO in the region, discussed and identified actionable recommendations based on findings from phase 2. Then, participants assessed their alignment with the WHO Global Strategy. At the end of the meeting, participants pledged to maintain the relationships between academia and policy makers and will work collectively toward UHC for oral health for all in the region based on the “Nairobi Declaration.” Knowledge Transfer Statement: This executive summary can be used by all key stakeholders involved in creating, disseminating, implementing, monitoring, and evaluating oral health policies in the African region to leverage research and accelerate the implementation of the WHO Global and African Regional Strategies on Oral Health.
Optimizing palliative care education nationwide: a practice example from The Netherlands
Authors: van Zuilekom Ingrid , Thiesen – van Staveren Jojanneke , Dericks-Issing Marijke , van den Brand Marieke , van Os-Medendorp Harmieke , Metselaar Suzanne 
Published: November 2024

Background: Every healthcare professional (HCP) in the Netherlands is expected to provide palliative care based on their initial education. This requires national consensus and clarity on the quality and goals of palliative care education and accessible education opportunities nationwide. These requirements were not met in the Netherlands, posing a major obstacle to improving the organization and delivery of palliative care. Therefore, a program, Optimizing Education and Training in Palliative Care (O2PZ), was established to improve palliative care education on a national level. Objectives: The main task of the O2PZ program from 2018 to 2021 was to implement and improve palliative care education in initial education for nursing and medical professionals. The program’s ultimate goal was that every HCP be sufficiently educated to provide high-quality generalist palliative care. Design: The O2PZ program consists of four projects to improve and consolidate generalist palliative care education nationwide. Methods: All projects used a participatory approach, that is, participatory development, implementation, and co-creation with stakeholders, mainly HCPs and education developers. Appreciative inquiry was used to assess, improve, and integrate existing local palliative care education initiatives. Results: (1) Establishment of an Education Framework for palliative care for all HCPs, including an interprofessional collaboration model; (2) optimization of palliative care education in the (initial) curricula of vocational education institutions and (applied) universities; (3) establishment of an online platform to disseminate materials to improve palliative care education; and (4) installment of seven regional palliative care education hubs, of which one hub was devoted to pediatric palliative care, as well as one national hub. Discussion: We discuss some lessons learned and challenges in accomplishing the goals of the O2PZ program in 2018–2021 and address how these challenges were dealt with. We maintain that co-creation with stakeholders at policy, organizational, and operational levels, as well as ongoing communication and collaboration, is essential to consolidating and implementing results. Conclusion: Over the past 4 years, we have improved generalist palliative care education nationwide for all HCPs through four projects in which we collaborated closely with stakeholders. This has resulted in more attention to and implementation of palliative care in education, a national Education Framework for palliative care, including an interprofessional collaboration model, an online platform for palliative care education, and palliative care education hubs covering all regions of the Netherlands.
Amblyopia rehabilitation: A preliminary study on the efficacy of an alternative therapeutic method within Italian patients
Authors: Bari Giambattista , D’Ambrosio Anna , Petrizzelli Francesco , Laborante Antonio 
Published: November 2024

Introduction: Amblyopia is the medical term for a “lazy eye.” It occurs when vision in one or both eyes does not develop properly during childhood even though there is no structural abnormality of the eye. It consists of an interocular difference of two lines or more in a visual acuity table (without specifying any), or visual acuity worse than or equal to 20/30 Snellen Feet equivalent to 0.2 LogMAR, with the best optical correction. (American Academy of Ophthalmology) Patching is the international gold standard amblyopia treatment, based on a monocular stimulation of the eye with lower vision. It needs high compliance and a long period of treatment during plastic age. The purpose of our work is to evaluate the efficiency of a different and faster method for amblyopia rehabilitation, useful even for patients out of the plastic age: specifically homebased binocular rehabilitation therapy through specific smartphone/tablet games combined with anagliphyc glasses. This method, due to its ease of use, high compliance and cheap cost, could reach a great number of patients that until now have the risk of being abandoned if they are not able, for different reason, to follow the others common therapies. Methods: Fifty-five patients: mean age 8.98 ± 5.38, underwent ophthalmologic and orthoptic evaluations for amblyopia: BVCA with ETDRS logMAR, stereoacuity with Lang Stereotest I, ocular motility examination, fundus oculi and cycloplegic refraction examination. Eligible children had ⩾0.2 (as applicable) logMAR interocular difference, or BVCA worse or equal to 0.2 LogMAR. Patients were rehabilitated with specific dichoptic treatment by digital videogames for 1 hour/day for 2 months. Children wore red–blue anaglyphic glasses to play the games (with low-contrast components visible to 1 eye and high-contrast components visible to the other eye) for 7 hours per week (1 hour per day) for 8 weeks, with 2 outcome examinations programmed by protocol at 4 and 8 weeks from baseline. Results: After 8 weeks of treatment, amblyopic eye BCVA improved from 0.28 ± 0.13 logMAR at baseline to 0.10 ± 0.09 ( P < .05) logMAR, with an improvement of 0.18 ± 0.09 logMAR. Conclusion: Achieved results relating to visual acuity improvements using binocular rehabilitation by digital videogames were statistically significant and encouraging. It is important that research and experimentation does not cease at this stage. Larger sample sizes, extended rehabilitation treatment periods and longer follow-up must be undertaken, in order to obtain objective data relating to visual acuity maintenance and also to obtained visual acuity results linked to age.
Impact of prior CAR T-cell therapy on mosunetuzumab efficacy in patients with relapsed or refractory B-cell lymphomas
Authors: Chong Elise A. , Penuel Elicia , Napier Ellen B. , Lundberg Rachel K. , Budde Lihua E. , Shadman Mazyar , Matasar Matthew J. , Bartlett Nancy L. , Flinn Ian W. , Bosch Francesc , Fay Keith , Goy Andre , Kumar Anita , Nastoupil Loretta J. , Wei Michael C. , Wu Mei , Yin Shen , Fraietta Joseph A. , Chong Emeline R. , Schuster Stephen J. 
Published: November 2024

Abstract
Mosunetuzumab and other CD20/CD3 bispecific antibodies (BsAbs) have efficacy in B-cell lymphomas relapsing after or refractory to CD19-directed chimeric antigen receptor (CAR)–modified T cells (CAR-T). The optimal timing of BsAbs and biomarkers of BsAb response after CAR-T are unknown. We addressed these questions using clinical data and blood samples from patients previously treated with CAR-T and subsequently treated on a phase 1/2 study of mosunetuzumab. Thirty patients had paired samples at baseline and after 1 cycle of mosunetuzumab. The median time from CAR-T to mosunetuzumab was significantly longer for responding than for nonresponding patients (P = .006, unadjusted for multiple comparisons). Most patients (20/30) did not receive intervening therapy between CAR-T administration and mosunetuzumab. The remainder of patients received 1 intervening therapy after a protocol-mandated drug washout. After mosunetuzumab, responding patients had higher lymphocytes (995 vs 400 cells per μL; P = .02) and greater increases in CD4 and CD8 cells (median change, 73 vs –90 cells per μL [P = .005] and 243 vs –103 cells per μL [P = .004], respectively). Additionally, responding patients had an increase in activated CD8 cells (median fold change, 1.7; P = .02). Nonresponders had a relative decrease in CAR transgene levels (n = 16; P = .04). This is, to our knowledge, the first study to assess changes in lymphocytes, T cells, and CAR transgene levels in patients treated with BsAbs after CAR-T. These findings suggest an interaction between prior CAR-T and BsAb outcomes and have implications for optimal timing of BsAb after CAR-T. The trial was registered at www.ClinicalTrials.gov as #NCT02500407.
Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea
Authors: Zinchuk Andrey V. , Kushida Clete A. , Walker Alexander , Wellman Andrew , Azarbarzin Ali , Alex Raichel M. , Varga Andrew W. , Sands Scott A. , Yaggi H. Klar 
Published: November 2024

BackgroundObstructive sleep apnoea (OSA) is associated with neurocognitive dysfunction. However, randomised trials evaluating the effects of continuous positive airway pressure (CPAP) on neurocognition in those without dementia do not show a benefit. We thus aimed to assess whether arousal threshold (ArTH) modifies the effect of CPAP on neurocognitive function.MethodsWe performed a secondary analysis of a randomised, sham-controlled trial (Apnea Positive Pressure Long-term Efficacy Study (APPLES);ClinicalTrials.gov:NCT00051363). ArTH was estimated from polysomnography using a translatable method. Neurocognitive outcomes included the Sustained Working Memory Test-Overall Mid-Day (SWMT-OMD) score (executive function, primary outcome), with the Pathfinder Number Test total time (attention) and Buschke Selective Reminding Test sum recall (learning and memory) as secondary outcomes. Generalised linear modelling assessed whether the effect of CPAP was modified by baseline ArTH (treatment×ArTH interaction). 833 participants with OSA (apnoea–hypopnoea index ≥10 events·h−1), available ArTH and outcomes were analysed (active CPAP n=437 and sham CPAP n=396).ResultsFor executive function, the effect of CPAP treatment was modified by ArTH (pinteraction=0.042). Specifically, for every 1sdincrease in ArTH, the SWMT-OMD score improved by 0.091 (95% CI 0.003–0.178) in active compared to sham CPAP at 6 months; at ArTH 1sdabove the mean, SWMT-OMD improvements were nearly three times that in those with average ArTH (0.139 (95% CI 0.018–0.261)versus0.053 (95% CI −0.034–0.140), respectively). No effect modification was observed for attention (p=0.311) or learning and memory (p=0.744).ConclusionIn OSA, a higher ArTH is associated with greater improvements in executive function following CPAP therapy.
Enhanced Surface Mechanical and Tribological Properties of H13 Die Steel with TiAlSiN Coating Deposited by HiPIMS
Authors: Lin Jun , Luan Hanxiao , Li Jiao , Zhai Jiqiang , Guan Yanjin , Zhao Guoqun , Bai Ruqing 
Published: November 2024

AbstractTiAlSiN is a potential protection coating for die steel to improve the surface hardness, anti-wear performance and suitability. In the present study, TiAlSiN is deposited on H13 die steel by high power impulse magnetron sputtering and the effects of bias voltage, deposition temperature, and film thickness on the performance of coatings are studied. The microstructure, mechanical and tribological properties of coatings are analyzed by energy dispersive spectrometer, X-ray diffraction, nanoindentation, friction and wear tests. The results show that with the changes of sputtering parameters, the content of Ti, Al, Si, and N fluctuates slightly. With the increase of bias voltage, deposition temperature and film thickness, the diffraction peaks of Ti3Al2N2 phase become wider. Higher bias voltage, deposition temperature, and film thickness are beneficial for obtaining coatings with high hardness, and strong wear resistance. By observing the surface morphology of coatings after grinding with Si3N4 balls, it was found that the wear mechanism of coatings contains abrasive wear, fatigue wear, and oxidative wear.