bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerco à liberdade: a complexa dinâmica do poder nos EUA
Authors: Azevedo Cecilia 
Published: June 2018

<em><span>Liberty and Coercion: The Paradox of American Government from the Founding to the Present</span></em><span>, publicado em 2015 pela prestigiosa Princeton University Press, se impõe como uma obra fundamental para todos os interessados em História dos Estados, como também o são dois livros anteriores do autor - <em>The rise and fall of the New Deal Order</em> (organizado em conjunto com Steve Fraser) e <em>The American Crucible: Race and Nation in the Twentieth Century.</em> Atualmente na Universidade de Cambridge, na Inglaterra, Gary Gerstle é sem dúvida nenhuma um dos maiores nomes da historiografia dos EUA, laureado com os mais relevantes prêmios ao longo de sua trajetória acadêmica no país. Após se notabilizar na História Social, enveredando por questões também caras à História Cultural, como a das identidades coletivas, Gerstle, com o livro em tela, contribui para o ímpeto recente da História Política, especificamente dos estudos sobre as instituições governamentais, tema que não despertou muito entusiasmo nos historiadores de sua geração. </span>
Editorial
Authors: Callejas Ivan Julio Apolonio 
Published: June 2018

A segunda edição de 2018 apresenta artigos relacionados à temática da sustentabilidade e das mudanças climáticas. A respeito do primeiro tema, os estudos concentram-se em área urbana e não urbana, enquanto no segundo, na identificação dos impactos projetados pelo Painel Intergovernamental sobre Mudanças Climáticas (IPCC) nas edificações.Em virtude da ação antrópica e visando criar condições para o desenvolvimento sustentável nos empreendimentos de implantação das rodovias, um dos estudos ressalta a necessidade de aplicação de métodos de Avaliação de Impacto Ambiental (AIA). Já dentro do meio urbano, há estudo que foca na necessidade de controlar a emissão de poluentes nos corpos d’água, enquanto outro apresenta caracterização fisiográfica e do uso e ocupação do solo das microbacias urbanas, demonstrando a influencia das ações do homem neste ecossistema. Há ainda estudo que indica a necessidade de planejamento integrado para garantir uma mobilidade urbana sustentável dentro das cidades.Quanto ao impacto estabelecido pelo IPCC, o estudo identifica a necessidade de se preocupar com os efeitos do aquecimento global nas estratégias passivas estabelecidas para algumas zonas bioclimáticas brasileiras. Os autores sugerem a necessidade de adaptar construtivamente as edificações para torna-las resilientes ao impacto às mudanças projetadas.Por fim, destaca-se esta edição é mais um esforço da equipe editorial em fornecer maior abrangência nacional à revista, focada na meta de elevação do seu conceito junto a CAPES. Ivan Julio Apolonio CallejasEditor chefe
A POÉTICA VISUAL DE ISAIAS MILIANO: Arte e Arqueologia na Amazônia
Authors: Baptaglin Leila Adriana , Ribeiro Acsa da Silva 
Published: June 2018

Este artigo tem como foco principal entender o processo de criação e poética do artista roraimense Isaias Miliano. Em relação a isto, a metodologia do trabalho seguirá da seguinte forma: Traremos o conceito do processo criativo e de poética com base nos autores: Marly Meira (2003), Luigi Passeron (1993), Sandra Rey (2002), e Bhabha (2005). Posterior a isso, trabalharemos com a concepção dos estereótipos na Amazônia a partir de autores: José Paes Loureiro (2015), Ana Pizarro (2005), Gil Braga (2006) e Bhabha (2005). Por fim, analisamos uma obra do artista intitulada Sol, que por meio desta resultou em uma análise, na qual, verificamos que em seu trabalho há o estudo sobre a identidade de Roraima, em que podemos entender a partir de três categorias: 1- Hibridização; 2- Artes; e 3- Discurso envolto a Amazônia.

PALAVRAS-CHAVES: Poética visual; Isaias Miliano; Arte; Arqueologia; Amazônia.

ABSTRACT
This article has as main focus to understand the process of creation and poetics of the artist rianoimense Isaias Miliano. Regarding this, the methodology of the work will follow as follows: We will bring the concept of the creative and poetic process based on the authors: Marly Meira (2003), Luigi Passeron (1993), Sandra Rey (2002) and Bhabha ). After that, we will work with the conception of stereotypes in the Amazon from authors: José Paes Loureiro (2015), Ana Pizarro (2005), Gil Braga (2006) and Bhabha (2005). Finally, we analyze a work by the artist entitled Sol, which through this resulted in an analysis, in which we verify that in his work there is the study on the identity of Roraima, in which we can understand from three categories: 1- Hybridization ; 2- Arts; and 3- Speech wrapped around the Amazon. KEYWORDS: Visual poetics; Isaias Miliano; Art; Archeology; Amazon.

RESUMEN
Este artículo tiene como foco principal entender el proceso de creación y poética del artista roraimense Isaias Miliano. En cuanto a esto, la metodología del trabajo seguirá de la siguiente manera: Traemos el concepto del proceso creativo y de poética basado en los autores: Marly Meira (2003), Luigi Passeron (1993), Sandra Rey (2002), y Bhabha (2005) ). Después de eso, trabajaremos con la concepción de los estereotipos en la Amazonía a partir de autores: José Paes Loureiro (2015), Ana Pizarro (2005), Gil Braga (2006) y Bhabha (2005). Por último, analizamos una obra del artista titulada Sol, que por medio de ésta resultó en un análisis, en la cual, verificamos que en su trabajo hay el estudio sobre la identidad de Roraima, en que podemos entender a partir de tres categorías: 1- Hibridación; 2- Artes; Y 3 - Discurso envuelto a la Amazonia.
PALABRAS CLAVES: Creación. Arte. Identidad.
Scapular Winging in the Pediatric Patient
Authors: Klyce Walter , Thome Andrew , Gil Joseph A. , Solga Patricia 
Published: June 2018

* Scapular winging is a rare condition that can lead to considerable functional impairment and cosmetic deformity but is frequently missed or misdiagnosed.* Scapular winging is of particular concern in the pediatric patient given its association with birth injuries, perinatal thoracic operations, inherited disorders, and potential malignancies.* Primary scapular winging may develop from nerve palsy, an osseous abnormality, or a soft-tissue defect.* Secondary scapular winging is typically due to glenohumeral dysfunction but can also be voluntary or habitual.
Revisão sistematizada das orientações sobre prevenção de distúrbios osteomusculares relacionados à Odontologia
Authors: Ferreira Maria Luisa Gomes , Endo Marcos Sergio , Fujimaki Mitsue , Lolli Luiz Fernando , Rocha Najara Barbosa da 
Published: June 2018

Introdução: Os distúrbios osteomusculares relacionados ao trabalho são comuns nos cirurgiões-dentistas. Porém, ainda há uma carência de estudos e discussões acerca desse tema. Objetivo: Identificar fatores de risco, as formas comuns de distúrbios osteomusculares relacionados ao trabalho na área de Odontologia e prevenção. Métodos: Realizou-se uma revisão de literatura nas bases de dados Lilacs, Medline e Scielo utilizando os descritores: Transtornos Traumáticos Cumulativos, Doenças Profissionais e Odontologia. Os critérios de inclusão foram: estudos sobre prevenção e tratamento de distúrbios osteomusculares relacionados ao trabalho na odontologia; trabalhos completos e disponíveis; idioma português ou inglês; todo tipo de estudo e sem restrição quanto ao ano de publicação. Resultados: A pesquisa resultou 32 artigos. Após leitura dos títulos e resumos foram selecionados 11 artigos para análise na íntegra. Destes, 6 foram excluídos após aplicação dos critérios de exclusão, totalizando 4 publicações. Os fatores de risco apontados para o desenvolvimento dos distúrbios osteomusculares foram os movimentos repetitivos, falta de ergonomia, postura inadequada, força excessiva nos procedimentos, repouso insuficiente, pouco condicionamento físico e pressão psicológica. As formas comuns apontadas foram tendinites, tenossinovites, síndrome do túnel do carpo, miosites e bursites. O diagnóstico da doença no Cirurgião-Dentista é realizado pelo estudo da vida profissional, história da doença e exame físico, com tratamento interprofissional. Para prevenção os estudos destacaram o estilo de vida saudável, a prática de esportes, alongamento, controle do estresse, organização e adoção de princípios ergonômicos. Conclusão: Os cirurgiões-dentistas são propensos aos distúrbios osteomusculares relacionados ao trabalho, sendo necessária prevenção destas patologias desde a graduação, pois hábitos deletérios podem ser prolongados para a vida profissional.Descritores: Transtornos Traumáticos Cumulativos; Doenças Profissionais; Programa de Prevenção de Riscos no Ambiente de Trabalho; Odontologia.
An Update on Potential Molecular Mechanisms Underlying the Actions of Snake Venom L-amino Acid Oxidases (LAAOs)
Authors: Paloschi Mauro V. , Pontes Adriana S. , Soares Andreimar M. , Zuliani Juliana P. 
Published: June 2018

Background:
LAAOs (EC 1.4.3.2) are found in concentrations that vary according to each
species of snakes; Viperidae, Crotalidae and Elapidae contain 1-9% of this enzyme in their venoms.

Methods:
This review focuses on an update on molecular mechanisms, platelet activities, antimicrobial,
antiprotozoal, induction of apoptosis and inflammatory potential underlying the actions of SVLAAOs.

Results:
Snake venom LAAOs (SV-LAAOs) have become an interesting subject for pharmacological,
structural and molecular studies.

Conclusion:
Although the mechanisms of action of these enzymes are not well understood they are a
subject of a variety of studies, because LAAOs are multifunctional enzymes exhibiting a wide range of
pharmacological effects, including the inhibition or induction of platelet aggregation, hemolysis and
hemorrhage, in addition to the stimulation of apoptosis, the activation of leukocytes and the formation
of edema.

Moreover, SV-LAAOs play an important role in bactericidal, cytotoxic, anti-parasitic, anti-tumor, and
antiviral activities.
A Study on the Synthesis of Risedronic Acid: The Role of an Ionic Liquid Additive
Authors: Nagy Dávid Illés , Grün Alajos , Sinkovicz Júlia , Garadnay Sándor , Greiner István , Keglevich György 
Published: June 2018

Background:
The synthesis of high value risedronic acid is not fully resolved, as, for the
time being, the best method based on the preparation from 3-pyridylcarboxylic acid by reaction
with phosphorus trichloride in methanesulfonic acid gives risedronic acid in a good yield, but in an
unpure form.

Methods:

Alternative protocols realizing the synthesis in sulfolane as the solvent and/or in the
presence of suitable IL additive were developed to obtain the target dronic acid in a pure form.

Results & Conclusion:

Using phosphorus trichloride and phosphorous acid in two equivalents
quantities together with 0.6 equivalents of [bmim][BF4] without any solvent, the method afforded
the target dronic acid in a yield of 66% in a pure form.
Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-triazole-1,2,4- Oxadiazole Hybrids as Potent Anti-breast Cancer Agents
Authors: Mohammadi-Khanaposhtani Maryam , Fahimi Kiana , Karimpour-Razkenari Elahe , Safavi Maliheh , Mahdavi Mohammad , Saeedi Mina , Akbarzadeh Tahmineh 
Published: June 2018

Background:
This work reports design, synthesis, and in vitro cytotoxicity of novel
coumarin-1,2,3-triazole-1,2,4-oxadiazole hybrids against three breast cancer cell lines MCF-7,
MDA-MB-231, and T-47D.

Methods:
Synthetic procedure for the preparation of desired compounds was started from the reaction
of coumarins or with propargyl bromide to give O-propargylated coumarins or 5. Then, click
reaction between the later compounds and 3-aryl-5-(chloromethyl)-1,2,4-oxadiazoles afforded the
desired products in good yields.

Results:
Among the synthesized compounds, 4-((1-((3-(4-chlorophenyl)-1,2,4-oxadiazol-5-
yl)methyl)-1H-1,2,3-triazol-4-yl)methoxy)-2H-chromen-2-one (9a) showed the best cytotoxicity
against breast cancer cell lines.

Conclusion:
Compound 9a depicted the most activity toward MDA-MB-231 and T-47D cells while
compounds 8a and 8c were the most potent compounds against MCF-7.
Molecular Dynamics Studies on COX-2 Protein-tyrosine Analogue Complex and Ligand-based Computational Analysis of Halo-substituted Tyrosine Analogues
Authors: Puratchikody Ayarivan , Umamaheswari Appavoo , Irfan Navabshan , Sriram Dharmarajan 
Published: June 2018

Background:
The quest for new drug entities and novel structural fragments with
applications in therapeutic areas is always at the core of medicinal chemistry.

Methods:
As part of our efforts to develop novel selective cyclooxygenase-2 (COX-2) inhibitors
containing tyrosine scaffold. The objective of this study was to identify potent COX-2 inhibitors by
dynamic simulation, pharmacophore and 3D-QSAR methodologies. Dynamics simulation was performed
for COX-2/tyrosine derivatives complex to characterise structure validation and binding
stability. Certainly, Arg120 and Tyr355 residue of COX-2 protein formed a constant interaction
with tyrosine inhibitor throughout the dynamic simulation phase. A four-point pharmacophore with
one hydrogen bond acceptor, two hydrophobic and one aromatic ring was developed using the
HypoGen algorithm. The generated, statistically significant pharmacophore model, Hypo 1 with a
correlation coefficient of r2, 0.941, root mean square deviation, 1.15 and total cost value of 96.85.

Results:
The QSAR results exhibited good internal (r2, 0.992) and external predictions (r2pred,
0.814). The results of this study concluded the COX-2 docked complex was stable and interactive
like experimental protein structure. Also, it offered vital chemical features with geometric constraints
responsible for the inhibition of the selective COX-2 enzyme by tyrosine derivatives.

Conclusion:
In principle, this work offers significant structural understandings to design and develop
novel COX-2 inhibitors.
Catalyst Free and Energy Economical Synthesis of Thiazole Derivatives Bearing Azo Imine Linkage with Imidazole as Antimicrobial Agents
Authors: Panchani Nayan M. , Joshi Hitendra S. 
Published: June 2018

Background:Several strategies have been reported for the synthesis of thiazole derivatives.Methods:However, many of these methods suffer from several drawbacks. Several modifications have been made to counter these problems. Here, we have synthesized a new series of 2-(2-((1HImidazol- 4-yl)methylene)hydrazinyl)-4-(4-substitutedphenyl)thiazoles without using the catalyst at room temperature.Results:The structures of synthesized compounds have been confirmed by spectral analysis, such as Mass, IR, 1H NMR and 13C NMR. All synthesized compounds were screened for in vitro antibacterial activity against some gram-positive and gram-negative bacteria.Conclusion:The thiazole derivatives, with a pharmacologically potent group, discussed in this article may provide valued therapeutic important in the treatment of microbial diseases, especially against bacterial and fungal infections.
Spectrum of Multimodality Findings in Post-surgical Breast Cancer Imaging
Authors: Ramli Hamid Marlina Tanty , Rahmat Kartini , Hamid Shamsiah Abdul , Kirat Singh Shaleen Kaur , Hooi Tan Gie 
Published: June 2018

Background:Breast cancer is the commonest cancer affecting Malaysian women, accounting for an estimated 30% of all new cancer diagnosed annually. Improvements in breast cancer management have increased the breast cancer survival rate in Malaysia. Clinical and radiological surveillance of the treated breast is vital, as early detection of recurrence improves patient’s survival rate.Discussion:As surgery and radiotherapy alter the appearance of the breasts, distinguishing between recurrence and benign post-surgical changes can be challenging radiologically due to overlapping features. Despite this, differentiation between these two entities is usually possible by recognizing characteristic features of post-treatment sequelae and the evolution of the appearance of the conservatively treated breast by comparing interval findings on serial studies.Conclusion:This pictorial review aims to describe the typical and unusual features of post-treated breasts in the multimodality imaging workup of an established breast care centre in a teaching hospital in Malaysia.
Analytical Quality by Design (AQbD) Approach Based HPTLC Method for Quantification of Fisetin with Superior Recovery in Formulations
Authors: Moolakkadath Thasleem , Aqil Mohd , Imam Syed Sarim , Ahad Abdul , Praveen Arshiya , Sultana Yasmin , Ahmad Sayeed , Mujeeb Mohd. 
Published: June 2018

Background:
A stability indicating high-performance thin layer chromatography (HPTLC)
method was developed for the evaluation of fisetin (FIS) in active pharmaceutical ingredient (API)
and marketed capsule formulation in accordance with the ICH guidelines.

Methods:
The mobile phase combination toluene: ethyl acetate: formic acid: methanol (3: 5.5: 1: 0.5
v/v/v/v) was optimized with the aid of AQbD approach. The absorbance mode at 254 nm was chosen
for densitometric analysis as it gives a compact spot of FIS at Rf value of 0.74.

Results:
The R2 value obtained from the linear regression equation of calibration plots made by taking
the spot in the concentration range of 100-1400 ng/spot was found to be 0.9993. The observed LOD
and LOQ value was found to be 29.8 ng/spot and 98.5 ng/spot, respectively. The exposure of FIS to
various stress conditions revealed the fact that the drug is stable in photochemical and dry heat stress
conditions without any degradation. The drug-exposed to acidic, alkaline and oxidative stress was
found to be degraded into different degradation products with the highest degradation was found in
alkaline stress. All degradation products were observed to be fairly separated from well-resolved parent
peak of FIS.

Conclusion:
The developed HPTLC method have shown well-resolved peaks and also shown good
recovery in the compound FIS as well as FIS formulation.
Factorial Design Optimisation of Solid Phase Extraction for Preconcentration of Parabens in Wastewater Using Ultra-High Performance Liquid Chromatography Triple Quadrupole Mass Spectrometry
Authors: Muckoya Vallerie A. , Nomngongo Philiswa N. , Ngila Jane C. 
Published: June 2018

Background:
Parabens are synthetic esters used extensively as preservatives and/or
bactericides in personal care personal products.

Objective:
Development and validation of a novel robust chemometric assisted analytical technique
with superior analytical performances for the determination of ethylparaben, methylparaben and
propylparaben, using simulated wastewater matrix.

Methods:
An automated Solid Phase Extraction (SPE) method coupled with liquid chromatographymass
spectrometry was applied in this study. A gradient elution programme comprising of 0.1%
formic acid in deionised water (A) and 0.1% formic acid in Methanol (B) was employed on a 100 x
2.1 mm, 3.0 μm a particle size biphenyl column. Two-level (2k) full factorial design coupled with
response surface methodology was used for optimisation and investigation of SPE experimental
variables that had the most significant outcome of the analytical response.

Results:
According to the analysis of variance (ANOVA), sample pH and eluent volume were
statistically the most significant parameters. The method developed was validated for accuracy,
precision, Limits of Detection (LOD) and Limit of Quantification (LOQ) and linearity. The LOD and
LOQ established under those optimised conditions varied between 0.04-0.12 μgL−1 and 0.14-0.40 μgL−1
respectively. The use of matrix-matched external calibration provided extraction recoveries between
78-128% with relative standard deviations at 2-11% for two spike levels (10 and 100 μgL-1) in three
different water matrices (simulated wastewater, influent and effluent water).

Conclusion:
The newly developed method was applied successfully to the analyses of parabens in
wastewater samples at different sampling points of a wastewater treatment plant, revealing
concentrations of up to 3 μgL−1.
The Optimization of HL60-IL6 Assay and its Application in the Pyrogen Detection of Monoclonal Antibody
Authors: Wang Mingren , Dong Shanshan , Shao Hong , Wang Can , Chen Gang 
Published: June 2018

Background:
The HL60-IL6 assay has been initially established, but the process of the assay
and calculation was not simplified. And there are no reports on whether it can be applied to detect pyrogen
contamination in the monoclonal antibody.

Objective:
The study aimed to improve the HL60/IL-6 assay and detect the pyrogens in the monoclonal
antibody drug by HL60-IL6 assay.

Methods:
The human promyelocytic leukemia cell line (HL-60) was incubated with pyrogen standard
solution, such as lipopolysaccharide (LPS), zymosan and lipoteichoic acid (LTA),or monoclonal antibody
sample solution for 48 hours, and then cytokines interleukin-6 (IL-6),secreted from HL-60, were
measured by ELISA. The study further described the standard curves on OD (Optical Density) value of
IL-6 responding to pyrogen stimulation, and determined the content of pyrogen in the monoclonal antibody
production after validation. In addition, the sensitivity of HL60 to three pyrogens was evaluated to
establish one standard curve to determine endotoxin and non-endotoxin level. Then, the credibility of
standard curves was evaluated. After improvement of the assay, 9 monoclonal antibody batches were
assayed for pyrogens in parallel with the Rabbit Pyrogen Test (RPT) and HL60/IL-6 assay.

Results:
It was achieved that the standard curve between OD value of IL-6 and pyrogen concentration
was established. Then, it was found that the sensitivity of HL60 responding to LPS was the weakest, as
a result of which, only LPS standard curve needs to be described in each test for detection of pyrogens.
Besides, to evaluate the credibility of standard curve, the parameters of the standard curve were restricted
and the resulting interpretation was also specified. 3 Bevacizumab batches failed the RPT,
which also showed pyrogenic contamination by the HL60/IL-6 assay.

Conclusion:
HL60-IL6 assay was improved and can be applied to pyrogen detection of monoclonal
antibody.
Pattern, Management, and Outcome of Poisoning in a Tertiary Care Hospital
Authors: Karki Naresh , Singh Vijay , Verma Vinod Kumar 
Published: June 2018

Introduction: Poisoning is a significant global public health problem. The appropriate management of poisoning at emergency needs accurate assessment and immediate treatment. The immense chance for better outcomes occurs with early diagnosis and treatment. This study was conducted to assess pattern, management, and outcome of poisoning in tertiary care hospital.
Methods: An observational cross-sectional study was conducted in which records of patients with a diagnosis of poisoning over a period of four years were reviewed.
Results: A total of 138 patients were included in the study. A majority (63%) of them were females. Most (67.4%) were managed by general or supportive measure only. Gastric lavage was done in 60% of total patients while 52.9% patients received activated charcoal. Pralidoxime and atropine was received by 51.1% of patients treated with specific antidote. All the antidotes were administered through intravenous route. Regarding outcome, 89.9% were completely recovered. Suicidal poisoning was significantly higher in married as compared to unmarried patients (p = 0.029). Similarly, there was a significant relationship between occupation of the patients and manner of poisoning (p = 0.003). Outcome of treatment had a significant association with the manner of poisoning (p < 0.001). Further analysis revealed that the patients who expired in the hospital were more likely to ingest poison accidentally.
Conclusion: Suicidal poisoning is common and females are more susceptible. Insecticide and rodenticide are the commonly ingested poisons. Treatment outcome of poisoning cases is generally favorable.