bluuebunny/crossref_metadata_2025_split huggingface dataset:
An application of full analytic hierarchy process to identify the best use of Dong Ngo closed‐landfill site in Bac Ninh city, Vietnam
Authors: Bui Thi Hong Hieu , Hoang Anh Duc , Kim Young Tae 
Published: May 2019

AbstractA landfill after going over its limit will be closed down and stop receiving waste. A matter of concern here is how to reuse the landfill site efficiently while there are many closed landfills have been transformed into new land uses in the world. The purpose of the study is to find the best land use of a closed‐landfill site after studying the characteristics of landfill site by using the analytic hierarchy process (AHP) method. The data used in the study were collected from surveys on 15 experts in three fields (environment, urban planning, and policy development) and the locals. The final results were based on their experience in evaluating the weight of criteria and alternatives in the same survey. To achieve the purpose of the study, three main criteria, six subcriteria, and five alternatives were identified as being relevant to the redevelopment of Dong Ngo landfill site, Bac Ninh province in Vietnam. Hierarchy of decision levels for Dong Ngo case study has been tested and developed from the data in reality and has successfully assessed the best use option as energy generation option for the landfill site under a scenario of decision making.
Private‐sector partner selection for public‐private partnership projects of electric vehicle charging infrastructure
Authors: Zhang Lihui , Zhao Zhenli , Kan Zhinan 
Published: May 2019

AbstractPublic‐private partnership (PPP) models, which can mitigate the deflection of charging facilities, have been introduced for electric vehicle charging infrastructure (EVCI) projects. Private‐sector partner selection is a significant step to ensure the success of EVCI‐PPP projects, but it has been rarely studied. This paper therefore identifies selection criteria for private partners in EVCI‐PPP projects and assesses the alternatives using an extended multicriteria operation and compromise solution (VIKOR) method. A partner selection indicator system is established through three development processes, and the factors are categorized into five factor packages: basic ability, management ability, performance of previous performance and credit performance, performance of projects, and sustainable development. These factors include 22 subcriteria. An extended VIKOR‐based method incorporating an intuitionistic fuzzy set is developed to select an optimal private partner. A case study is used to verify the effectiveness and rationalization of the proposed approach. Three potential candidates, P1, P2, P3, are evaluated and ranked according to their evaluation scores, and the results show that P1 is the best partner solution. Relevant charging infrastructure project experience, technical level in charging facilities, and financing plan are the top three criteria for choosing appropriate partners for EVCI‐PPP projects. This study provides a comprehensive evaluation framework for the government to select suitable private‐sector partners to accelerate the sustainable development of charging facilities.
On the Creation of Risk: Framing of Microplastics Risks in Science and Media
Authors: Völker Carolin , Kramm Johanna , Wagner Martin 
Published: May 2019

AbstractThe public is concerned about plastic pollution, while clear‐cut scientific evidence for an environmental risk of microplastics is absent. This contrast between incomplete scientific knowledge and public risk perception is an interesting case for investigating how “environmental risk” is transformed in science communication. This study examines how microplastics risks are framed in peer‐reviewed publications and online newspaper articles, respectively. It also analyzes if the contents conveyed by the frames used in science and the media are consistent. The results show that most scientific studies (67%) frame microplastics risks as hypothetical or uncertain, while 24% present them as established. In contrast, most media articles reporting on microplastic impacts (93%) imply that risks of microplastics exist and harmful consequences are highly probable. The creation of simple narratives (journalists) and the emphasis on potentially negative impacts (scientists) contribute to this inconsistency. The transformation of an uncertain risk into an actual risk is further caused by two inconsistent risk conceptions, namely risk being the probability of a negative outcome (environmental scientists) or being the uncertainty of a negative outcome itself (public). Although the latter differs from the risks identified “objectively” by scientific methods, it allows understanding the risk perception of the public and decision‐makers.
Subcortical amyloid load is associated with shape and volume in cognitively normal individuals
Authors: Rahayel Shady , Bocti Christian , Sévigny Dupont Pénélope , Joannette Maude , Lavallée Marie Maxime , Nikelski Jim , Chertkow Howard , Joubert Sven 
Published: May 2019

AbstractAmyloid‐beta (Aβ) deposition is one of the main hallmarks of Alzheimer's disease. The study assessed the associations between cortical and subcortical 11C‐Pittsburgh Compound B (PiB) retention, namely, in the hippocampus, amygdala, putamen, caudate, pallidum, and thalamus, and subcortical morphology in cognitively normal individuals. We recruited 104 cognitive normal individuals who underwent extensive neuropsychological assessment, PiB–positron emission tomography (PET) scan, and 3‐T magnetic resonance imaging (MRI) acquisition of T1‐weighted images. Global, cortical, and subcortical regional PiB retention values were derived from each scan and subcortical morphology analyses were performed to investigate vertex‐wise local surface and global volumes, including the hippocampal subfields volumes. We found that subcortical regional Aβ was associated with the surface of the hippocampus, thalamus, and pallidum, with changes being due to volume and shape. Hippocampal Aβ was marginally associated with volume of the whole hippocampus as well as with the CA1 subfield, subiculum, and molecular layer. Participants showing higher subcortical Aβ also showed worse cognitive performance and smaller hippocampal volumes. In contrast, global and cortical PiB uptake did not associate with any subcortical metrics. This study shows that subcortical Aβ is associated with subcortical surface morphology in cognitively normal individuals. This study highlights the importance of quantifying subcortical regional PiB retention values in these individuals.
Thromboelastography‐Guided Blood Component Use in Patients With Cirrhosis With Nonvariceal Bleeding: A Randomized Controlled Trial
Authors: Kumar Manoj , Ahmad Juned , Maiwall Rakhi , Choudhury Ashok , Bajpai Meenu , Mitra Lalita G. , Saluja Vandana , Mohan Agarwal Prashant , Bihari Chhagan , Shasthry Saggere Muralikrishna , Jindal Ankur , Bhardwaj Ankit , Kumar Guresh , Sarin Shiv K. 
Published: May 2019

Thromboelastography (TEG) provides a more comprehensive global coagulation assessment than routine tests (international normalized ratio [INR] and platelet [PLT] count), and its use may avoid unnecessary blood component transfusion in patients with advanced cirrhosis and significant coagulopathy who have nonvariceal upper gastrointestinal (GI) bleeding. A total of 96 patients with significant coagulopathy (defined in this study as INR >1.8 and/or PLT count < 50 × 109/L) and nonvariceal upper GI bleed (diagnosed after doing upper gastrointestinal endoscopy, which showed ongoing bleed from a nonvariceal source) were randomly allocated to TEG‐guided transfusion strategy (TEG group; n = 49) or standard‐of‐care (SOC) group (n = 47). In the TEG group, only 26.5% patients were transfused with all three blood components (fresh frozen plasma [FFP], PLTs, and cryoprecipitate) versus 87.2% in the SOC group (P < 0.001). Although 7 (14.3%) patients in the TEG group received no blood component transfusion, there were no such patients in the SOC group (P = 0.012). Also, there was a significantly lower use of blood components (FFP, PLTs, and cryoprecipitate) in the TEG group compared with the SOC group. Failure to control bleed, failure to prevent rebleeds, and mortality between the two groups were similar. Conclusion: In patients with advanced cirrhosis with coagulopathy and nonvariceal upper GI bleeding, TEG‐guided transfusion strategy leads to a significantly lower use of blood components compared with SOC (transfusion guided by INR and PLT count), without an increase in failure to control bleed, failure to prevent rebleed, and mortality.
Time series analysis of ambient air pollution effects on dynamic stroke mortality
Authors: Luo Li , Dai Yuting , Zhang Fengyi , Chen Mei , Chen Fang , Qing Fang 
Published: May 2019

SummaryThis study aims to examine the correlations between air pollution and dynamic stroke mortality, which is defined as the daily real‐time number of deaths from stroke. Death data were obtained from daily medical records of 7230 incidents from the Center for Disease Control and Prevention in the Longquanyi District of China from 2016 to 2017. Air pollution data were obtained from environmental monitoring stations in the Longquanyi District. Time series analysis using generalized additive Poisson regression models was applied, and single‐pollutant and two‐pollutant adjusted models were utilized. Furthermore, categories based on gender, age, and meteorological factors were considered in the analysis. The results indicated that PM2.5, PM10, O3, and CO had significant effects on dynamic stroke mortality, which were stronger for older people and during the cold season. This study helps hospital managers, patients, and governments seeking to prevent and control the effects of air pollution on the risks of stroke.
Differences in the health behaviors of elderly individuals and influencing factors: Evidence from the ChineseLongitudinalHealthyLongevitySurvey
Authors: Liu Erpeng , Feng Yan , Yue Zhang , Zhang Qilin , Han Tiankuo 
Published: May 2019

SummaryIntroductionHealth behaviors play an important role in determining individual health status; thus, understanding differences in the health behaviors of elderly individuals and their influencing factors is a prerequisite for the formulation and implementation of health behavior promotion policies for elderly individuals. The objectives of this study were to explore differences in health behaviors among Chinese elderly people and their influencing factors.MethodsBased on data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) in 2014, this paper applied latent class analysis (LCA) to explore differences in the health behaviors of elderly individuals in China and employed a multinomial logit model to identify the influencing factors that cause these differences.ResultsResults showed that there are five classes of health behaviors among elderly individuals in China: passive, relatively passive, general, relatively positive, and positive, the proportions of which were 31.07%, 15.86%, 24.06%, 17.24%, and 11.76%, respectively. Community medical and health services, pension, living arrangements, and family income were the primary factors explaining differences in the health behaviors of elderly individuals. In addition, there were significant demographic differences in the health behaviors of elderly individuals in China, including gender, age, education, marital status, census register, region, and others.ConclusionThere are significant differences in the behaviors of elderly individuals in China, and the behaviors of the majority of elderly people are not healthy. China is expected to invest more medical and health resources to tackle health prevention and management and to provide targeted education, guidance, and intervention in elderly health behaviors, urging them to control and correct risky health behaviors with a focus on elderly individuals that are the oldest, are females, have low education levels, and live in the countryside and in towns.
Optimization of Canal Water in an Irrigation Network Based on a Genetic Algorithm: A Case Study of the North China Plain Canal System
Authors: Yao Weiwei , Ma Xiaoyi , Chen Yuansheng 
Published: May 2019

AbstractMaximizing the efficiency of water distribution in canals requires clear guidelines and criteria for system design and operation. Studies have shown that optimization models based on a genetic algorithm (GA) provide a reasonable arrangement of canal water allocation times and discharges, which reduces water transportation losses. In this study, a GA was developed and implemented in the North China Plain canal system, which has 24 minor canals and a command area of approximately 1800 ha. The optimization results indicated that the total seepage loss and evapotranspiration in the canal system decreased from 249 000 to 115 000 m3. Furthermore, the total water requirement decreased from 1 170 000 to 1 040 000 m3. This study suggests that revising water delivery schedules could increase water productivity, and reduce water leakage and total water requirements. © 2019 John Wiley & Sons, Ltd.
GIS‐Based Surface Irrigation Potential Assessment for Ethiopian River Basin
Authors: Birhanu Asfaw , Murlidhar Pingale Santosh , Soundharajan Bankaru‐Swamy , Singh Pratap 
Published: May 2019

AbstractThe suitability of the Dirma River Basin in Ethiopia for surface irrigation potential development and identification of potentially irrigable sites were the subject of the present study. The river basin area suitability was evaluated based on slope, soil and surface water resource availability using ArcGIS 10.1. Potentially suitable sites for surface irrigation development were evaluated for potato and tomato crops. The reference crop evapotranspiration, effective rainfall, net irrigation and gross irrigation water requirement were estimated using CROPWAT software. The results of the suitability model developed indicated that about 68.3% of the total river basin area falls in marginally to highly suitable categories for surface irrigation development. The water resource availability reveals that due to very high intra‐annual variability in river flows, only 6% of the mean annual flow is available for the period from January to May, and with this up to 30% of land that is suitable for surface irrigation can be irrigated. However, with suitable water storage infrastructure and deficit irrigation practices, utilization of land and water resources of the Dirma River Basin can be increased significantly. Therefore, this study will help decision makers, investors, planners and policymakers at the local, regional and national levels in better identification of profitable and sustainable irrigation investment opportunities in the region. © 2019 John Wiley & Sons, Ltd.
A novel method for evaluating and quantifying cell types in platelet rich fibrin and an introduction to horizontal centrifugation
Authors: Miron Richard J. , Chai Jihua , Zheng Shihang , Feng Mengge , Sculean Anton , Zhang Yufeng 
Published: May 2019

AbstractPlatelet rich fibrin (PRF) has been utilized clinically as a platelet concentrate capable of stimulating tissue regeneration. Interestingly, several protocols have been proposed with little data obtained regarding the final cell counts following centrifugation. The aim of the present study was to compare different commercially available centrifuges and their respective protocols utilizing a novel method to quantify cells. One millimeter blood layers following centrifugation were sequentially pipetted from the upper layer downward until all 10 mL were harvested in sequential samples. Thereafter, each sample was sent for CBC analysis to accurately quantify precisely cell numbers within each separate blood layer following centrifugation. The results from this study revealed that L‐PRF protocols (2700 rpm × 12 min) produced a clot with the majority of platelets and leukocytes concentrated within the buffy coat with relatively no cells found within the first 4 mL of L‐PRF. Slower centrifugation protocols produced using the A‐PRF protocols (1300 rpm × 8 min) produced a more evenly distributed number of platelets throughout PRF. Injectable‐PRF (i‐PRF) protocols produced the highest concentration of leukocytes/platelets, however, the total number of leukocytes and platelets were significantly lower owing to the decreased total volume collected. Horizontal centrifugation produced a significant increase in both the number and concentration of platelets and leukocytes (up to 3.5× higher for either solid/liquid PRF). When compared to either fixed or angled centrifuge (InstraSpin, Process for PRF). In conclusion, the present study revealed a novel/accurate method to quantify cells following PRF protocols. Furthermore, PRF produced via horizontal centrifugation accumulated a higher number and concentration of platelets/leukocytes when compared to either fixed‐angle centrifugation.
Combination of arsenic trioxide and cisplatin synergistically inhibits both hexokinase activity and viability of Ehrlich ascites carcinoma cells
Authors: Mansour Mohammed A. , Ibrahim Wafaa M. , Shalaan Eman S. , Salama Afrah F. 
Published: May 2019

AbstractHexokinase‐2 is overexpressed in several carcinomas including breast cancer to sustain energy for rapidly dividing cells and associates with chemoresistance. However, the impact of chemo drugs (alone or in combination) on hexokinase activity and autophagic cell death is unclear. In this report, we used an in vivo murine adenocarcinoma model to validate the effects of As2O3 and cisplatin on hexokinase activity and autophagic cancer cell death. We found that the two drugs inhibit hexokinase activity and induce autophagic marker, beclin 1 expression. Interestingly, combining As2O3 with cisplatin synergistically enhanced these effects and alleviated oxidative stress often encountered in As2O3 treatment. Altogether, our data provide direct evidence that inhibition of hexokinase activity and induction of autophagic cell death are mediating the antineoplastic effects of As2O3 and cisplatin. Our findings raise the potential of combining As2O3 with cisplatin as an approach to augment cisplatin‐induced cell death and combat cisplatin chemoresistance in cancer.
p53 induces miR‐199a‐3p to suppress mechanistic target of rapamycin activation in cisplatin‐induced acute kidney injury
Authors: Yang Aicheng , Liu Fanna , Guan Baozhang , Luo Zhi , Lin Jiehua , Fang Wan , Liu Longhui , Zuo Wanli 
Published: May 2019

AbstractHow p53 participates in acute kidney injury (AKI) progress and what are the underlying mechanisms remain illusive. For this issue, it is important to probe into the role of p53 in cisplatin‐induced AKI. We find that p53 was upregulated in cisplatin‐induced AKI, yet, pifithrin‐α inhibites the p53 expression to attenuated renal injury and cell apoptosis both in vivo cisplatin‐induced AKI mice and in vitro HK‐2 human renal tubular epithelial cells. To knock down p53 by siRNA significantly decreased the miRNA, miR‐199a‐3p, expression in HK‐2 cells. Blockade of miR‐199a‐3p significantly reduced cisplatin‐induced cell apoptosis and inhibited caspase‐3 activity. Mechanistically, we identified that miR‐199a‐3p directly bound to mechanistic target of rapamycin (mTOR) 3′‐untranslated region and overexpressed miR‐199a‐3p reduce the expression and phosphorylation of mTOR. Furthermore, we demonstrated that p53 inhibited mTOR activation through activating miR‐199a‐3p. In conclusion, our findings reveal that p53, upregulating the expression of miR‐199a‐3p affects the progress of cisplatin‐induced AKI, which might provide a promising therapeutic target of AKI.
The decreased lncRNA ZEB2‐AS1 in pre‐eclampsia controls the trophoblastic cell line HTR‐8/SVneo's invasive and migratory abilities via the miR‐149/PGF axis
Authors: Gao Yu , Guo Xiaohui , Li Yan , Sha Wenqiong , She Ruilian 
Published: May 2019

AbstractPre‐eclampsia (PE) is a pregnancy disease that causes maternal death and threatens the health of newborns. Accumulating evidence has revealed the essential roles of long noncoding RNAs (lncRNAs) in the progression of PE. The present investigation determined lncRNA ZEB2 antisense RNA 1 (ZEB2‐AS1) expression in PE and looked into the potential role of ZEB2‐AS1 in modulating trophoblastic cell functions. Quantitative real‐time polymerase chain reaction evaluated gene expression. Western blot analyzed the placental growth factor (PGF) protein level. Cell counting kit‐8 and Transwell invasion assays assessed the proliferative and invasive abilities of placental trophoblast cells, respectively. Wound healing assay determined cell migratory potentials. Dual‐luciferase reporter assay assessed the targeting relationship among ZEB2‐AS1, miR‐149, and PGF. Downregulation of lncRNA ZEB2‐AS1 was detected in placentas from patients with PE when compared with those from normal pregnancies. Moreover, ZEB2‐AS1 upregulation markedly promoted proliferative, migratory, and invasive potentials in HTR‐8/SVneo cells, while knockdown of ZEB2‐AS1 had the opposite effects. The effects on HTR‐8/SVneo cells mediated by ZEB2‐AS1 was correlated with the miR‐149/PGF axis. These findings indicate that ZEB2‐AS1 contributes to PE progression by affecting cell proliferative and invasive capacities via the miR‐149/PGF axis in HTR‐8/SVneo cells. In sum, we identified that ZEB2‐AS1 was a novel aberrantly expressed lncRNA in the placentas of PE patients and lncRNA ZEB2‐AS1 modulated trophoblastic cell line HTR‐8/SVneo's proliferative and invasive potentials via targeting the miR‐149/PGF axis.
Stereological and gene expression examinations on the combined effects of photobiomodulation and curcumin on wound healing in type one diabetic rats
Authors: Amini Abdollah , Soleimani Hasan , Abdollhifar Mohammad‐Amin , Moradi Ali , Ghoreishi Seyed Kamran , Chien Sufan , Bayat Mohammad 
Published: May 2019

AbstractWe examined the effects of photobiomodulation (PBM) independently and combined with curcumin on stereological parameters and basic fibroblast growth factor (bFGF), hypoxia‐inducible factor‐1α (HIF‐1α), and stromal cell‐derived factor‐1α (SDF‐1α) gene expressions in an excisional wound model of rats with type one diabetes mellitus (T1DM). T1DM was induced by an injection of streptozotocin (STZ) in each of the 90 male Wistar rats. One round excision was generated in the skin on the back of each of the 108 rats. The rats were divided into six groups (n = 18 per group): control (diabetic), untreated group; vehicle (diabetic) group, which received sesame oil; PBM (diabetic) group; curcumin (diabetic) group; PBM + curcumin (diabetic) group; and a healthy control group. On days 4, 7, and 15, we conducted both stereological and quantitative real‐time PCR (qRT‐PCR) analyses. The PBM and PBM + curcumin groups had significantly better inflammatory response modulation in terms of macrophages (P < .01), neutrophils (P < .001), and increased fibroblast values compared with the other groups at day 4 (P < .001), day 7 (P < .01), and day 15 (P < .001). PBM treatment resulted in increased bFGF gene expression on days 4 (P < .001) and 7 (P < .001), and SDF‐1α gene expression on day 4 (P < .001). The curcumin group had increased bFGF (P < .001) expression on day 4. Both the PBM and PBM + curcumin groups significantly increased wound healing by modulation of the inflammatory response, and increased fibroblast values and angiogenesis. The PBM group increased bFGF and SDF‐1α according to stereological and gene expression analyses compared with the other groups. The PBM and PBM + curcumin groups significantly increased the skin injury repair process to more rapidly reach the proliferation phase of the wound healing in T1DM rats.