bluuebunny/crossref_metadata_2025_split huggingface dataset:
GlialHMOX1expression promotes central and peripheral α‐synuclein dysregulation and pathogenicity in parkinsonian mice
Authors: Cressatti Marisa , Song Wei , Turk Ariana Z. , Garabed Laurianne R. , Benchaya Joshua A. , Galindez Carmela , Liberman Adrienne , Schipper Hyman M. 
Published: June 2019

Abstractα‐Synuclein is a key player in the pathogenesis of Parkinson disease (PD). Expression of human heme oxygenase‐1 (HO‐1) in astrocytes of GFAP.HMOX1 transgenic (TG) mice between 8.5 and 19 months of age results in a parkinsonian phenotype characterized by neural oxidative stress, nigrostriatal hypodopaminergia associated with locomotor incoordination, and overproduction of α‐synuclein. We identified two microRNAs (miR‐), miR‐153 and miR‐223, that negatively regulate α‐synuclein in the basal ganglia of male and female GFAP.HMOX1 mice. Serum concentrations of both miRNAs progressively declined in the wild‐type (WT) and GFAP.HMOX1 mice between 11 and 19 months of age. Moreover, at each time point surveyed, circulating levels of miR‐153 were significantly lower in the TG animals compared to WT controls, while α‐synuclein protein concentrations were elevated in erythrocytes of the GFAP.HMOX1 mice at 19 months of age relative to WT values. Primary WT neurons co‐cultured with GFAP.HMOX1 astrocytes exhibited enhanced protein oxidation, mitophagy and apoptosis, aberrant expression of genes regulating the dopaminergic phenotype, and an imbalance in gene expression profiles governing mitochondrial fission and fusion. Many, but not all, of these neuronal abnormalities were abrogated by small interfering RNA (siRNA) knockdown of α‐synuclein, implicating α‐synuclein as a potent, albeit partial, mediator of HO‐1's neurodystrophic effects in these parkinsonian mice. Overexpression of HO‐1 in stressed astroglia has previously been documented in the substantia nigra of idiopathic PD and may promote α‐synuclein production and toxicity by downmodulating miR‐153 and/or miR‐223 both within the CNS and in peripheral tissues.
Factors for predicting reversion from mild cognitive impairment to normal cognition: A meta‐analysis
Authors: Xue HuiPing , Hou Ping , Li YongNan , Mao Xin'e , Wu LinFeng , Liu YongBing 
Published: June 2019

ObjectiveSubjects with mild cognitive impairment (MCI) may revert to normal cognition (NC), but predictive factors are under study. We therefore sought to identify factors which could help in predicting reversion from MCI to NC.MethodsRelevant studies were retrieved from PubMed, EMBASE, Cochrane Library, MEDLINE, Web of Science, EBSCO, and OVID. According to the inclusion and exclusion criteria, high‐quality assessments of relevant literatures were conducted, followed by data extraction and meta‐analysis with Stata 12.0 software.ResultsA total of 17 studies with 6829 participants were included in the meta‐analysis. The overall reversion rate is 27.57%. Positive predictive factors were found in younger age (SMD = −0.345, 95% CI, −0.501 to −0.189), higher education level (SMD = 0.337, 95% CI, 0.117‐0.558), no APOE ε4 allele (OR = 0.728, 95% CI, 0.575‐0.922), no hypertension (OR = 0.826, 95% CI, 0.692‐0.987), no stroke (OR = 0.696, 95% CI, 0.507‐0.953), and higher Mini‐Mental State Examination (MMSE) score (SMD = 0.707, 95% CI, 0.461‐0.953).ConclusionIndividuals who are at young age, have higher education level and MMSE score, and have no APOEe4 allele, no hypertension, and no stroke had a high probability to revert from MCI to NC.
Stimuli, presentation modality, and load‐specific brain activity patterns during n‐back task
Authors: Mencarelli Lucia , Neri Francesco , Momi Davide , Menardi Arianna , Rossi Simone , Rossi Alessandro , Santarnecchi Emiliano 
Published: June 2019

AbstractWorking memory (WM) refers to a set of cognitive processes that allows for the temporary storage and manipulation of information, crucial for everyday life skills. WM deficits are present in several neurological, psychiatric, and neurodevelopmental disorders, thus making the full understanding of its neural correlates a key aspect for the implementation of cognitive training interventions. Here, we present a quantitative meta‐analysis focusing on the underlying neural substrates upon which the n‐back, one of the most commonly used tasks for WM assessment, is believed to rely on, as highlighted by functional magnetic resonance imaging and positron emission tomography findings. Relevant published work was scrutinized through the activation likelihood estimate (ALE) statistical framework in order to generate a set of task‐specific activation maps, according to n‐back difficulty. Our results confirm the known involvement of frontoparietal areas across different types of n‐back tasks, as well as the recruitment of subcortical structures, cerebellum and precuneus. Specific activations maps for four stimuli types, six presentation modalities, three WM loads and their combination are provided and discussed. Moreover, functional overlap with resting‐state networks highlighted a strong similarity between n‐back nodes and the Dorsal Attention Network, with less overlap with other networks like Salience, Language, and Sensorimotor ones. Additionally, neural deactivations during n‐back tasks and their functional connectivity profile were examined. Clinical and functional implications are discussed in the context of potential noninvasive brain stimulation and cognitive enhancement/rehabilitation programs.
Hemothorax during miniaturized endoscopic combined intrarenal surgery under ureteroscope‐assisted ultrasound‐guided access
Authors: Tanaka Yutaro , Taguchi Kazumi , Hamamoto Shuzo , Ota Yuya , Oda Risa , Yokota Keisuke , Ando Ryosuke , Okada Atsushi , Tozawa Keiichi , Nakanishi Ryoichi , Yasui Takahiro 
Published: June 2019

IntroductionHemothorax is a rare but life‐threatening complication following mini‐endoscopic combined intrarenal surgery. Herein, we describe a patient with left staghorn kidney stone who presented with hemothorax following mini‐endoscopic combined intrarenal surgery under ureteroscope‐assisted ultrasound‐guided access.Case presentationA 47‐year‐old woman with left staghorn kidney stone underwent mini‐endoscopic combined intrarenal surgery, after which she developed shortness of breath. Chest radiography and computed tomography confirmed left hemothorax. Conservative management and left intercostal chest drainage were performed without improvement. Subsequently, video‐assisted thoracoscopic debridement was performed.ConclusionHemothorax is a severe complication of mini‐endoscopic combined intrarenal surgery, which, regardless of accurate access through an ideal renal calyx under ureteroscope‐assisted ultrasound‐guided access, may lead to pleural injury. Refinement of the surgical technique and management after percutaneous nephrolithotomy is the key to avoiding life‐threatening situations.
Classification of mammogram images using the energy probability in frequency domain and most discriminative power coefficients
Authors: Benhassine Nasser Edinne , Boukaache Abdelnour , Boudjehem Djalil 
Published: June 2019

AbstractThe purpose of this work is to develop a computer‐aided diagnosis (CAD) system to assist radiologists in the classification of mammogram images. The CAD system is composed of three main steps. The first step is image preprocessing and segmentation with the seeded region growing algorithm applied on a localized triangular region to remove only the muscle. In the second step of the CAD system, we proposed a novel features extraction method, which consists of three stages. In the first, the discrete cosine transform (DCT) is applied on all obtained regions of interest and then only the upper left corner (ULC) of DCT coefficients is retained. Second, we have applied the energy probability to the ULCs that is used as a criterion for selecting discriminant information. At the last stage, a new Most Discriminative power coefficient algorithm has been proposed to select the most significant features. In the final step of the CAD, the support vector machines, Naive Bayes, and artificial neural network (ANN) classifiers are used to make an effective classification. The evaluation of the proposed algorithm on the mini‐Mammographic Image Analysis Society database shows its efficiency over other recently proposed CAD systems in the literature, whereas an accuracy of 100% can be achieved using ANN with a small number of features.
Apatite minerals derived from collagen phosphorylation modification induce the hierarchical intrafibrillar mineralization of collagen fibers
Authors: Du Tianming , Niu Xufeng , Hou Sen , Li Zhengwei , Li Ping , Fan Yubo 
Published: June 2019

AbstractCollagen is the critical organic component of bone matrix, which is the template for bone biomineralization. Phosphorylation modification of collagen plays an important role in the process of biomineralization in vivo, but its mechanism on in vitro biomimetic mineralization of bone matrix remains unclear at the molecular level. Sodium tripolyphosphate is used to phosphorylate collagen in this study and new phosphate groups appear on collagen fibrils after phosphorylation modification. The chelating amount of calcium is improved linearly with increasing the phosphorylation degree of collagen fibrils, which demonstrates that the introduced phosphate groups serve as new nucleation sites and participate in the formation of apatite minerals inside the collagen fibers. Stabilized nanosized amorphous calcium phosphate by polyacrylic acid can also permeate into collagen fibers and further transform into another layer of hydroxyapatite minerals. Both layers of apatite minerals eventually induce the formation of hierarchical intrafibrillar mineralization structure within the phosphorylated collagen fibers. The present research enriches the previous biomineralization mechanism of bone matrix, provides a facile strategy for biomimetic mineralization of collagen, and offers the basis for future investigation of the advanced bone substitute materials.
Guidelines on the Use of Therapeutic Apheresis in Clinical Practice – Evidence‐Based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue
Authors: Padmanabhan Anand , Connelly‐Smith Laura , Aqui Nicole , Balogun Rasheed A. , Klingel Reinhard , Meyer Erin , Pham Huy P. , Schneiderman Jennifer , Witt Volker , Wu Yanyun , Zantek Nicole D. , Dunbar Nancy M. , Schwartz Guest Editor: Joseph 
Published: June 2019

ABSTRACTThe American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA) Special Issue Writing Committee is charged with reviewing, updating and categorizing indications for the evidence‐based use of therapeutic apheresis (TA) in human disease. Since the 2007 JCA Special Issue (Fourth Edition), the committee has incorporated systematic review and evidence‐based approaches in the grading and categorization of apheresis indications. This Eighth Edition of the JCA Special Issue continues to maintain this methodology and rigor in order to make recommendations on the use of apheresis in a wide variety of diseases/conditions. The JCA Eighth Edition, like its predecessor, continues to apply the category and grading system definitions in fact sheets. The general layout and concept of a fact sheet that was introduced in the Fourth Edition, has largely been maintained in this edition. Each fact sheet succinctly summarizes the evidence for the use of TA in a specific disease entity or medical condition. The Eighth Edition comprises 84 fact sheets for relevant diseases and medical conditions, with 157 graded and categorized indications and/or TA modalities. The Eighth Edition of the JCA Special Issue seeks to continue to serve as a key resource that guides the utilization of TA in the treatment of human disease.
Self‐assembly: An intriguing relationship between structures of metal complexes and shapes of ancient Chinese characters
Authors: Thanasekaran Pounraj , Luo Tzuoo‐Tsair , Kao Ya‐Chuan , Lin Chih‐Chien , Yang Chen‐I , Lu Kuang‐Lieh 
Published: June 2019

AbstractSelf‐assembly is a fundamental principle, which generates structural organization on all scales from molecules to galaxies. In the field of chemistry and materials science, the self‐assembly process driven by noncovalent interactions offers considerable advantages over the stepwise bond formation in the construction of large supramolecular assemblies with different sizes and shapes. The structures of metal clusters are mainly constructed from the assembly of mononuclear metal center to dinuclear, trinuclear species, and so on. It is of interest that Chinese ancient people also used this concept to create and encrypt characters. Herein, we report on an intriguing relationship between structures of metal complexes and the shapes of ancient Chinese characters, in which the self‐assembly principle is clearly demonstrated.
Proteomics analysis of human serum of patients with non‐small‐cell lung cancer reveals proteins as diagnostic biomarker candidates
Authors: Boccellino Mariarosaria , Pinto Federica , Ieluzzi Vincenzo , Giovane Alfonso , Quagliuolo Lucio , Fariello Chiara , Coppola Mario , Carlucci Annalisa , Santini Mario , Ferati Kenan , Bexheti‐Ferati Arbëresha , Giordano Antonio , Di Domenico Marina 
Published: June 2019

AbstractNon‐small‐cell lung carcinomas (NSCLC) is the most common type of lung cancer and it has a poor prognosis, because overall survival after 5 years is 20–25% for all stages. Thus, it is extremely important to increase the survival rate in the early stages NSCLC by focusing on novel screening tests of cancer identifying specific biomarkers expression associated with a more accurate tumor staging and patient prognosis. In this study, we focused our attention on quantitative proteomics of three heavily glycosylated serum proteins: AMBP, α2 macroglobulin, and SERPINA1. In particular, we analyzed serum samples from 20 NSCLC lung adenocarcinoma cancer patients in early and advanced stages, and 10 healthy donors to obtain a relative quantification through the MRM analysis of these proteins that have shown to be markers of cancer development and progression. AMBP, α2 macroglobulin, and SERPINA1 were chosen because all of them possess endopeptidase inhibitor activity and play key roles in cancer. We observe a variation in the expression of these proteins linked to the stage of the disease. Therefore, we believe that proteins like α2 macroglobulin, αmicroglobulin/bikunin, and SERPINA1 could be useful biomarkers for early detection of lung cancer and in monitoring its evolution.
Early response and safety of lenvatinib for patients with advanced hepatocellular carcinoma in a real‐world setting
Authors: Sho Takuya , Suda Goki , Ogawa Koji , Kimura Megumi , Shimazaki Tomoe , Maehara Osamu , Shigesawa Taku , Suzuki Kazuharu , Nakamura Akihisa , Ohara Masatsugu , Umemura Machiko , Kawagishi Naoki , Natsuizaka Mitsuteru , Nakai Masato , Morikawa Kenichi , Furuya Ken , Baba Masaru , Yamamoto Yoshiya , Kobayashi Tomoe , Meguro Takashi , Saga Akiyoshi , Miyagishima Takuto , Yokoo Hideki , Kamiyama Toshiya , Taketomi Akinobu , Sakamoto Naoya 
Published: June 2019

Background and AimLenvatinib has been recently approved as a first‐line systematic therapy for patients with advanced hepatocellular carcinoma (HCC) based on the results of the phase 3 clinical trial REFLECT. This trial excluded patients with a history of systemic chemotherapy, bile duct invasion, and Child‐Pugh grade B. We aimed to investigate the efficacy and safety of lenvatinib for these patients and in the real‐world setting.MethodsAmong patients who were administered lenvatinib for advanced HCC between April and October 2018 in Hokkaido University Hospital and related hospitals, we evaluated those who were followed for more than 2 months and whose treatment response was evaluated via dynamic computed tomography at baseline and 2 months after treatment initiation. Meanwhile, patients were excluded if they had decompensated liver cirrhosis, were followed up less than 2 months, or were not evaluated at 2 months. Patients were also stratified according to compliance with the REFLECT inclusion criteria for further analysis.ResultsA total of 41 patients were included; more than 50% did not meet the REFLECT inclusion criteria. In total, 5 (12.2%), 20 (48.8%), 12 (29.3%), and 4 (9.3%) showed complete response, partial response, stable disease, and progressive disease, respectively. The objective response rate was 61.2%. The objective response rate and disease control rate were similar between patients who did and did not meet the REFLECT inclusion criteria. Moreover, the safety profile was also similar between the two patient groups.ConclusionLenvatinib showed high early response rate and tolerability in patients with advanced HCC. Favorable outcomes were similarly observed in patients who did not meet the REFLECT inclusion criteria.
Impact of the frequency of plasma viral load monitoring on treatment outcomes among children with perinatally acquired HIV
Authors: Sudjaritruk Tavitiya , Boettiger David C , Nguyen Lam Van , Mohamed Thahira J , Wati Dewi K , Bunupuradah Torsak , Hansudewechakul Rawiwan , Ly Penh S , Lumbiganon Pagakrong , Nallusamy Revathy A , Fong Moy S , Chokephaibulkit Kulkanya , Nik Yusoff Nik K , Truong Khanh H , Do Viet C , Sohn Annette H , Sirisanthana Virat ,   the TREAT Asia Pediatric HIV Observational Database of IeDEA Asia‐Pacific
Published: June 2019

AbstractIntroductionRecommendations on the optimal frequency of plasma viral load (pVL) monitoring in children living with HIV (CLWH) who are stable on combination antiretroviral therapy (cART) are inconsistent. This study aimed to determine the impact of annual versus semi‐annual pVL monitoring on treatment outcomes in Asian CLWH.MethodsData on children with perinatally acquired HIV aged <18 years on first‐line, non‐nucleoside reverse transcriptase inhibitor‐based cART with viral suppression (two consecutive pVL <400 copies/mL over a six‐month period) were included from a regional cohort study; those exposed to prior mono‐ or dual antiretroviral treatment were excluded. Frequency of pVL monitoring was determined at the site‐level based on the median rate of pVL measurement: annual 0.75 to 1.5, and semi‐annual >1.5 tests/patient/year. Treatment failure was defined as virologic failure (two consecutive pVL >1000 copies/mL), change of antiretroviral drug class, or death. Baseline was the date of the second consecutive pVL <400 copies/mL. Competing risk regression models were used to identify predictors of treatment failure.ResultsDuring January 2008 to March 2015, there were 1220 eligible children from 10 sites that performed at least annual pVL monitoring, 1042 (85%) and 178 (15%) were from sites performing annual (n = 6) and semi‐annual pVL monitoring (n = 4) respectively. Pre‐cART, 675 children (55%) had World Health Organization clinical stage 3 or 4, the median nadir CD4 percentage was 9%, and the median pVL was 5.2 log10 copies/mL. At baseline, the median age was 9.2 years, 64% were on nevirapine‐based regimens, the median cART duration was 1.6 years, and the median CD4 percentage was 26%. Over the follow‐up period, 258 (25%) CLWH with annual and 40 (23%) with semi‐annual pVL monitoring developed treatment failure, corresponding to incidence rates of 5.4 (95% CI: 4.8 to 6.1) and 4.3 (95% CI: 3.1 to 5.8) per 100 patient‐years of follow‐up respectively (p = 0.27). In multivariable analyses, the frequency of pVL monitoring was not associated with treatment failure (adjusted hazard ratio: 1.12; 95% CI: 0.80 to 1.59).ConclusionsAnnual compared to semi‐annual pVL monitoring was not associated with an increased risk of treatment failure in our cohort of virally suppressed children with perinatally acquired HIV on first‐line NNRTI‐based cART.
Superficial, suprahyoid, and infrahyoid neck musculature in naked mole‐rats (Heterocephalus glaber): Relative size and potential contributions to independent movement of the lower incisors
Authors: Cain Blake W. , Reynolds Taylor , Sarko Diana K. 
Published: June 2019

AbstractNaked mole‐rats (Heterocephalus glaber) are fossorial, eusocial rodents that exhibit the unusual capability of moving their lower incisors independently in lateral and rostroventral directions. The evolution of this trait would presumably also involve concurrent alterations in neck musculature to support and control movements of the lower incisors. In order to assess morphological adaptations that might facilitate these movements, we performed detailed dissections of the neck musculature of adult naked mole‐rats. In addition to characterizing attachment sites of superficial, suprahyoid, and infrahyoid musculature, we also quantified muscle mass and mandibular features thought to be associated with gape (condyle height, condyle length, and jaw length). Based on muscle attachment sites, the platysma myoides may contribute to lateral movement of the lower incisor and hemi‐mandible in naked mole‐rats. The large digastric muscle is likely to be a main contributor to rostroventral movement of each lower incisor. The geniohyoid and mylohyoid muscles also likely contribute to rostroventral movements of the lower incisors, and the mylohyoid may also produce lateral spreading of the hemi‐mandibles. The transverse mandibular (intermandibularis) muscle likely serves to reposition the lower incisors back to a midline orientation following a movement.
Spillover effects of supply chain news on consumers' perceptions of product quality: An examination within the triple bottom line
Authors: Nichols Bridget Satinover , Stolze Hannah , Kirchoff Jon F. 
Published: June 2019

AbstractThe purpose of this research is to examine the impact that news about supply chain operations related to the triple bottom line (TBL) has on consumers' perceptions. Specifically, it focuses on how sustainability successes and failures in a company's supply chain operations influence consumer perceptions of product quality. These perceptions are based on a spillover effect. The research study is set up across three experiments. Study one tests for the spillover effect in supply chain TBL‐related news and demonstrates that negative supply chain news across all three TBL dimensions reduces quality perceptions. Study two examines the effect across three levels of negative news intensity and finds that the spillover effect is consistent, even with stronger levels of negativity. Study three investigates whether a firm can improve damaged quality perceptions and purchase intentions through a recovery effort. The results of study three suggest that consumers' perceptions and purchase intentions are generally reparable. Collectively, the findings should encourage firms to more rigorously consider how news about their supply chain operations may impact consumers' perceptions and intentions toward the firm's products.
Increased miR‐323a induces bladder cancer cell apoptosis by suppressing c‐Met
Authors: Qiu Jun , Zeng Fu‐Ren , Fang Yi , Li Jian , Xiao Sheng‐Ying 
Published: June 2019

AbstractThe current study aimed to evaluate the expression and role of miR‐323a in the progression of bladder cancer (BC), thereby providing a theoretical basis and potential therapy methods for BC patients. Our data showed that miR‐323a levels were significantly reduced in BC tissues compared with those of non‐cancerous tissues. Meanwhile, miR‐323a was significantly decreased in human BC cell lines (T24, J82, TCCSUP, RT‐112) than that in human normal bladder epithelial cell line SV‐HUC‐1. Furthermore, inhibition of miR‐323a markedly enhanced the migration and invasive capacity of T24 and TCCSUP cells. Moreover, overexpression of miR‐323a significantly prompted the apoptosis of BC cells. Dual luciferase reporter assay and western blot analysis confirmed that c‐Met was a target gene of miR‐323a. More importantly, upregulation of c‐Met significantly prompted BC cell proliferation mainly as a result of the enhanced level of phosphorylation of AKT. This effect could be abolished when c‐Met was silenced in BC cells. In summary, reduced miR‐323a expression in BC contributed to enhanced BC cell proliferation and migration mainly by targeting c‐Met.