bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eric Strach: Four Decades of Detailed Synoptic Solar Observations (1969‐2008)
Authors: Carrasco V. M. S. , Vaquero J. M. , Olmo‐Mateos V. M. 
Published: May 2019

AbstractEric H. Strach (1914‐2011) studied medicine at University of Prague and graduated in 1938. Strach dedicated a great part of his life to astronomy becoming a consistent and meticulous observer. He joined the Liverpool Astronomical Association and British Astronomical Association during the 1960s and obtained two recognitions as proof of his great work in solar physics: the BAA's Merlin Medal and Gift in 1999 and Walter Goodacre Medal and Gift, 10 years later. Strach recorded four decades (1969‐2008) of systematic solar records in his observation notebooks although he started his observations from the late 1950s. In this work, we document the valuable effort made by Strach in getting four decades of solar records and the importance of this kind of long observation series for studies of space weather and climate. We present the sunspot group number series according to Strach's data and a long observation series of prominences recorded by Strach.
High‐Resolution Potassium Observations of the Lunar Exosphere
Authors: Rosborough S. A. , Oliversen R. J. , Mierkiewicz E. J. , Sarantos M. , Robertson S. D. , Kuruppuaratchi D. C. P. , Derr N. J. , Gallant M. A. , Roesler F. L. 
Published: May 2019

AbstractWe observed lunar exospheric potassium D1 (7,698.9646 Å) emissions using a high‐spectral resolution Fabry‐Perot spectrometer in 2014. We present the first potassium line profile measurements, which are representative of the potassium velocity distribution. Inferred temperatures are greater during the waxing gibbous phase, 1920±630 K and lower at waning gibbous phase, 980±200 K. Exosphere models suggest that the measured line widths are a combination of photon‐stimulated desorption and impact vaporization sources. The relative potassium emission intensity decreases by ∼2.5 between lunar phases 80° and 30° and is brightest off the northwest limb near the Aristarchus crater, which is a potassium‐rich surface region. Additionally, the emissions off the northern limb are brighter than the southern limb. The intensity decrease and the greater line width during the waxing gibbous versus the waning gibbous phase suggests a dawn‐dusk asymmetry.
Item Bias: Predictors of Accuracy on Peabody Picture Vocabulary Test–Fourth Edition Items for Spanish-English–Speaking Children
Authors: Wood Carla , Schatschneider Christopher 
Published: May 2019

PurposeThis study examines the response patterns of 278 Spanish–English dual language learners (DLLs) on a standardized test of receptive English vocabulary.MethodInvestigators analyzed responses to 131 items on the Peabody Picture Vocabulary Test–Fourth Edition (Dunn & Dunn, 2007) focusing on differential accuracy on items influenced by (a) cross-linguistic overlap in phonology, (b) part of speech, and (c) word frequency.ResultsThe differential response patterns showed cross-linguistic overlap, part of speech, and word frequency were significant predictors of the likelihood of obtaining a correct response above and beyond the expected difficulty level of the item.ConclusionsAll 3 factors predicted DLLs' response patterns beyond expected difficulty. Items with the highest likelihood of error included words with few or no shared features between Spanish and English translation equivalents, verbs or modifiers, and words with low frequency of occurrence.ImplicationsResearchers should consider a cross-linguistic overlap in addition to part of speech and word frequency when designing vocabulary assessments for DLLs or utilizing such tests in research and clinical practice. Recognizing potential bias, clinicians should triangulate the appraisal of DLLs' language skills across multiple sources or measures and use caution when interpreting vocabulary assessments.
Impact of the development of an endoscopic eradication program for Barrett’s esophagus with high grade dysplasia or early adenocarcinoma on the frequency of surgery
Authors: Chilukuri Prianka , Gromski Mark A. , Johnson Cynthia S. , Ceppa Duy Khanh P. , Kesler Kenneth A. , Birdas Thomas J. , Rieger Karen M. , Fatima Hala , Kessler William R. , Rex Douglas K. , Al-Haddad Mohammad , DeWitt John M. 
Published: May 2019

AbstractBackground and aims The impact of the advent of an institutional endoscopic eradication therapy (EET) program on surgical practice for Barrett’s esophagus (BE)-associated high grade dysplasia (HGD) or suspected T1a esophageal adenocarcinoma (EAC) is unknown. The aims of this study are to evaluate the different endoscopic modalities used during development of our EET program and factors associated with the use of EET or surgery for these patients after its development.Methods Patients who underwent primary endoscopic or surgical treatment for BE-HGD or early EAC at our hospital between January 1992 and December 2014 were retrospectively identified. They were categorized by their initial modality of treatment during the first year, and the impact over time for choice of therapy was assessed by multivariable logistic regression.Results We identified 386 patients and 80 patients who underwent EET and surgery, respectively. EET included single modality therapy in 254 (66 %) patients and multimodal therapy in 132 (34 %) patients. Multivariable logistic regression showed that, for each subsequent study year, EET was more likely to be performed in patients who were older (P = 0.0009), with shorter BE lengths (P < 0.0001), and with a pretreatment diagnosis of HGD (P = 0.0054) compared to surgical patients. The diagnosis of EAC did not increase the utilization of EET compared to surgery as time progressed (P = 0.8165).Conclusion The introduction of an EET program at our hospital increased the odds of utilizing EET versus surgery over time for initial treatment of patients who were older, had shorter BE lengths or the diagnosis of BE-HGD, but not in patients with EAC.
Doppelangriff bei invasiver Pilzrhinosinusitis: Antimykotikum plus Debridement
Authors: Werner Franziska 
Published: May 2019

Die akute invasive fungale Rhinosinusitis (AIFRS) ist eine potenziell letale Erkrankung – Inzidenz steigend. Entscheidend für das Überleben sind eine frühe Diagnosesicherung und ein frühzeitiger Therapiebeginn. Indische Forscher um R. Shanbag berichten nun über ihre positiven 2-Jahres-Erfahrungen mit einem primär medikamentös-chirurgischen Vorgehen – der Kombination von liposomalem Amphotherizin B (Lip AmB) und endoskopischem Debridement.
Reactions of t-Boc-Protected Amines with Difluorocarbene
Authors: Gerasov Andrii , Shivanyuk Alexander , Fetyukhin Volodymyr , Lukin Oleg 
Published: May 2019

The reactions of t-Boc-protected secondary and primary amines with difluorocarbene generated from trimethylsilyl (fluorosulfonyl)difluoroacetate [Me3SiOC(O)CF2SO2F] (TFDA) in toluene at 110 °C results in the replacement of t-Bu by difluoromethyl in the t-Boc group. This reaction can be carried out in the presence of CH2Br and COOMe moieties in the structure of the protected amine. In the example of a t-Boc-protected amine containing a C=C double bond, replacement of the t-Bu group and/or cyclodifluoropropanation takes place. Difluoromethyl esters are shown to react with primary and secondary amines yielding the corresponding ureas.
Fluid Management in Acute Respiratory Distress Syndrome
Authors: Casey Jonathan , Semler Matthew , Rice Todd 
Published: May 2019

AbstractOne of the defining features of acute respiratory distress syndrome (ARDS) is noncardiogenic pulmonary edema, resulting from increased permeability of the alveolar–capillary barrier and passage of protein-rich fluid into the interstitium and alveolar spaces. The loss of protein from the intravascular space disrupts the normal oncotic pressure differential and causes patients with ARDS to be particularly sensitive to the hydrostatic forces that correlate with intravascular volume. Conservative fluid management, in which diuretics are administered and intravenous fluid administration is minimized, may decrease hydrostatic pressure and increase serum oncotic pressure, potentially limiting the development of pulmonary edema. However, the cause of death in most patients with ARDS is multiorgan system failure, not hypoxemia, and the impact of conservative fluid management on the incidence of extrapulmonary organ failure during ARDS is unclear. These physiologic observations have led to a series of studies examining the impact of fluid management on the development of, resolution of, survival from, and long-term outcomes from ARDS. While questions remain, the current literature makes it clear that fluid management is an integral part of the care of patients with ARDS.
Cholesterol Starvation and Hypoxia Activate the FVII Gene via the SREBP1-GILZ Pathway in Ovarian Cancer Cells to Produce Procoagulant Microvesicles
Authors: Koizume Shiro , Takahashi Tomoko , Yoshihara Mitsuyo , Nakamura Yoshiyasu , Ruf Wolfram , Takenaka Katsuya , Miyagi Etsuko , Miyagi Yohei 
Published: May 2019

AbstractInteraction between the transcription factors, hypoxia-inducible factor (HIF1α and HIF2α) and Sp1, mediates hypoxia-driven expression of FVII gene encoding coagulation factor VII (fVII) in ovarian clear cell carcinoma (CCC) cells. This mechanism is synergistically enhanced in response to serum starvation, a condition possibly associated with tumor hypoxia. This transcriptional response potentially results in venous thromboembolism, a common complication in cancer patients by producing procoagulant extracellular vesicles (EVs). However, which deficient serum factors are responsible for this characteristic transcriptional mechanism is unknown. Here, we report that cholesterol deficiency mediates synergistic FVII expression under serum starvation and hypoxia (SSH) via novel sterol regulatory element binding protein-1 (SREBP1)-driven mechanisms. Unlike conventional mechanisms, SREBP1 indirectly enhances FVII transcription through the induction of a new target, glucocorticoid-induced leucine zipper (GILZ) protein. GILZ expression induced in response to hypoxia by a HIF1α-dependent mechanism activates SREBP1 under SSH, suggesting reciprocal regulation between SREBP1 and GILZ. Furthermore, GILZ binds to the FVII locus. Xenograft tumor samples analyzed by chromatin immunoprecipitation confirmed that HIF1α-aryl hydrocarbon nuclear translocator and GILZ bind to the TSC22D3 (GILZ) and FVII gene loci, respectively, thereby potentially modulating chromatin function to augment FVII transcription. Thus, deficiency of both O2 and cholesterol, followed by interplay between HIFs, Sp1, and SREBP1-GILZ pathways synergistically induce fVII synthesis, resulting in the shedding of procoagulant EVs.
Sciatic Nerve to Pudendal Nerve Transfer: Anatomical Feasibility for a New Proposed Technique
Authors: Agarwal Pawan , Sharma Dhananjaya , Wankhede Sudesh , Jain P. C. , Agrawal N. L. 
Published: May 2019

Abstract
Aim Restoration of bladder and bowel continence after pudendal nerve anastomosis has been shown successfully in animal models and may be applicable in humans. Aim of this cadaveric study was to assess feasibility of pudendal nerve neurotization using motor fascicles from sciatic nerve.
Methods Pudendal and sciatic nerves were exposed via gluteal approach in 5 human cadavers (10 sites). Size of pudendal and sciatic nerves and the distance between two nerves was measured.
Results There were four male and one female cadavers. Mean age was 62 (range, 50–70) years. Mean pudendal nerve diameter was 2.94 mm (right side) and 2.82 mm (left side). Mean sciatic nerve diameter was 11.2 mm (right side) and 14.2 mm (left side). The distance between two nerves was 23.4 mm on both sides.
Conclusion Transfer of the motor fascicles from sciatic nerve to pudendal nerve to restore the bladder and bowel continence is feasible.
Patient and companion shared decision making and satisfaction with decisions about starting cholinesterase medication at dementia diagnosis
Authors: McCabe Rose , Pavlickova Hana , Xanthopoulou Penny , Bass Nick J , Livingston Gill , Dooley Jemima 
Published: May 2019

Abstract

Background
there is little research on how people with dementia are involved in treatment decisions at diagnosis.

Objective
to measure shared decision making when starting cholinesterase inhibitors, investigate associations with contextual factors and explore satisfaction and experience of the diagnostic meeting.

Setting
nine UK memory clinics in two geographical locations.

Subjects
74 people receiving dementia diagnoses (with 69 companions) and 21 doctors.

Methods
we video-recorded 74 memory clinic consultations and rated doctor-shared decision making behaviours using the Observing Patient Involvement in Decision Making scale (OPTION-5 scale). Patients and companions rated their satisfaction and experience. Mixed-effects regressions investigated involvement and (i) number people present, meeting length, capacity, cognitive functioning, diagnosis; and (ii) patient/companion satisfaction and consultation experience.

Results
mean consultation time was 26.7 min. Mean OPTION-5 score was 22.5/100 (Standard Deviation = 17.3). Doctors involved patients in decisions more often when patients had mixed dementia (β = 10.13, 95% confidence interval 1.25–19.0, P = 0.025) and in shorter meetings (β = −0.51, 95% CI −0.87 to −0.15, P = 0.006). Patient and companion satisfaction were high and not associated with whether doctors invited patient involvement. Half of patients and one-third companions were uncertain about the meeting outcome, experienced communication barriers and negative emotions.

Conclusions
consultations scored low on shared decision making, but were comparable to other settings and were not lower with more cognitively impaired patients. Negative patient and companion experiences reflect the importance of supporting healthcare providers to address patient and companion emotions and need for information.
Does grandparental care select for a longer lifespan in non-human mammals?
Authors: Péron Guillaume , Bonenfant Christophe , Lemaitre Jean-François , Ronget Victor , Tidiere Morgane , Gaillard Jean-Michel 
Published: May 2019

Abstract
Several non-human mammalian species provide grandparental care but remain fertile until death, unlike our species. This might call into question the ‘grandmother hypothesis’ that the ability to provide grandparental care, associated with an increase in the cost of breeding with age, promote the early cessation of reproduction. Here, we analyse individual longevity records from non-human mammals to determine whether the few species with grandparental care also stand out among mammals in terms of age-specific survival patterns. Indeed, females of species with grandparental care lived on average 43% longer than males (range: 24–61%), compared with 12% in other polygynous species (95% quantile: −8 to 30%), because of low baseline mortality rates and delayed onset of actuarial senescence. We discuss this finding with respect to the ‘stopping early’ vs. ‘living longer’ debate. We review the role of the environmental context and of the decrease in offspring performance with maternal age (Lansing effect). We formalize the idea of a continuum of parental–grandparental allocation instead of a discrete switch to grandparental care only. Lastly, we suggest that the evolution of menopause has been driven by different forces in different species.
Anaplastic Large Cell T Cell Lymphoma in a Patient With Severe Therapy-refractory Crohn’s Disease on Long-standing Immunosuppressive Medication During Ustekinumab Treatment: A Case Report and Review of the Literature
Authors: Smeets Fabiënne G M , Liedorp Paulien R , van der Poel Marjolein , Miclea Razvan L , Masclee Ad A M , Pierik Marieke 
Published: May 2019

Abstract
Use of ustekinumab in Crohn’s disease was approved in 2016, and consequently data regarding its real-world safety are still limited. We here present a 29-year-old woman with severe therapy-refractory Crohn’s disease, who developed an anaplastic large cell T cell lymphoma during treatment with ustekinumab.
Successful right heart remodelling and subsequent pregnancy in a patient with chronic thromboembolic pulmonary hypertension undergoing balloon pulmonary angioplasty: a case report
Authors: Ikeda Nobutaka , Hatano Masaru , Nagamatsu Takeshi , Nakamura Masato 
Published: May 2019

AbstractBackgroundTo date, the management of pregnancy in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and the associated risk of maternal mortality have not been established. Although balloon pulmonary angioplasty (BPA) in patients with CTEPH is still an emerging procedure, this approach represents a promising alternative to pulmonary endarterectomy (PEA), especially in patients with inoperable CTEPH.Case summaryWe present a case of a 34-year-old woman with CTEPH who desired to have a child. Right heart catheterization showed a mean pulmonary artery pressure of 54 mmHg. Since the lesions were observed in the distal part of subsegmental pulmonary arteries, there was no indication for PEA. After improvement in her haemodynamic status by BPA, she became pregnant. At 40 weeks of gestation, a normal baby was delivered vaginally. Both mother and baby have made satisfactory progress.DiscussionIn cases in which the haemodynamic status is improved by effective BPA, pregnancy and childbirth may be possible, even in patients with CTEPH.
Relationship between degree of heparin anticoagulation and clinical outcome in patients receiving potent P2Y12-inhibitors with no planned glycoprotein IIb/IIIa inhibitor during percutaneous coronary intervention in acute myocardial infarction: a VALIDATE-SWEDEHEART substudy
Authors: Sharma Tania , Rylance Rebecca , Karlsson Sofia , Koul Sasha , Venetsanos Dimitrios , Omerovic Elmir , Fröbert Ole , Persson Jonas , James Stefan , Erlinge David 
Published: May 2019

Abstract

Aims
Heparin is the preferred choice of anticoagulant in percutaneous coronary intervention (PCI) for acute myocardial infarction (MI). An established dosage of heparin has not yet been determined, but treatment may be optimized through monitoring of activated clotting time (ACT). The aim of this study was to determine the relationship between heparin dose or ACT with a composite outcome of death, MI, or bleeding using data from the registry-based, randomized, controlled, and open-label VALIDATE-SWEDEHEART trial, although patients were not randomized to heparin dose in this substudy.

Methods and results
Patients with MI undergoing PCI and receiving treatment with a potent P2Y12-inhibitor and anticoagulation with heparin, without the planned use of glycoprotein IIb/IIIa inhibitor (GPI), were enrolled in this substudy. The primary endpoint was a composite endpoint of death, MI, and bleeding at 30 days. The individual components and stent thrombosis were analysed separately. We divided patients into groups according to the initial dose of unfractionated heparin during PCI (&lt;70 U/kg, 70–100 U/kg, and &gt;100 U/kg) or ACT (ACT &lt;250 s, 250–350 s, and &gt;350 s) as well as investigating them as continuous variables in Cox proportional hazards models using univariable and multivariable analyses. No major differences were noted between heparin stratified in groups (P = 0.22) or heparin as a continuous variable in relation to the primary composite endpoint hazard ratio (HR) 1.0 confidence interval (CI) (0.99–1.01) for heparin dose/kg. No differences were found between ACT stratified in groups (P = 0.453) or ACT in seconds HR 1.0 CI (0.99–1.00) regarding the primary endpoint. The individual components of death, MI, major bleeding, and stent thrombosis were not significantly different across heparin doses or ACT levels either.

Conclusion
We found no association between heparin dose or ACT levels and death, MI bleeding complications, or stent thrombosis. Therefore, there is no strong support for a specific heparin dose or mandatory ACT monitoring in patients treated with potent P2Y12-inhibitors with no planned GPI.
Carbon Emission Flow and Transfer through International Trade of Forest Products
Authors: Shrestha Prativa , Sun Changyou 
Published: May 2019

Abstract
The environmental impact of commodity trade has become a considerable concern in recent decades. In this study, carbon emissions embodied in forest products trade are examined through a multiregional input–output model. Compared with other industries, the forest products industry is clean with a small total emission and mean emission intensity. The paper sector is more substantial in total emission and dirtier in emission intensity than the wood sector. Most countries with extensive forest products trade have experienced declining consumption-based carbon emissions over 1995–2009, and all countries have become cleaner based on the emission intensity value. Carbon emissions embodied in international trade of forest products are about 25 percent of total emissions from production activities. Developing countries generally have much higher emission intensities than developed countries. Uncertainties in the carbon emission data have a larger impact than those in the intermediate and final consumption data. These findings are helpful for policymakers to understand the economic–environmental relations of forest products trade and to improve policy and agreement designs.
Revisiting the Evolution and Taxonomy of Clostridia, a Phylogenomic Update
Authors: Cruz-Morales Pablo , Orellana Camila A , Moutafis George , Moonen Glenn , Rincon Gonzalo , Nielsen Lars K , Marcellin Esteban 
Published: May 2019

AbstractClostridium is a large genus of obligate anaerobes belonging to the Firmicutes phylum of bacteria, most of which have a Gram-positive cell wall structure. The genus includes significant human and animal pathogens, causative of potentially deadly diseases such as tetanus and botulism. Despite their relevance and many studies suggesting that they are not a monophyletic group, the taxonomy of the group has largely been neglected. Currently, species belonging to the genus are placed in the unnatural order defined as Clostridiales, which includes the class Clostridia. Here, we used genomic data from 779 strains to study the taxonomy and evolution of the group. This analysis allowed us to 1) confirm that the group is composed of more than one genus, 2) detect major differences between pathogens classified as a single species within the group of authentic Clostridium spp. (sensu stricto), 3) identify inconsistencies between taxonomy and toxin evolution that reflect on the pervasive misclassification of strains, and 4) identify differential traits within central metabolism of members of what has been defined earlier and confirmed by us as cluster I. Our analysis shows that the current taxonomic classification of Clostridium species hinders the prediction of functions and traits, suggests a new classification for this fascinating class of bacteria, and highlights the importance of phylogenomics for taxonomic studies.