bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Accurate Is Inverse Electrocardiographic Mapping?
Authors: Bear Laura R. , LeGrice Ian J. , Sands Gregory B. , Lever Nigel A. , Loiselle Denis S. , Paterson David J. , Cheng Leo K. , Smaill Bruce H. 
Published: April 2018

Background:
Inverse electrocardiographic mapping reconstructs cardiac electrical activity from recorded body surface potentials. This noninvasive technique has been used to identify potential ablation targets. Despite this, there has been little systematic evaluation of its reliability.

Methods:

Torso and ventricular epicardial potentials were recorded simultaneously in anesthetized, closed-chest pigs (n=5), during sinus rhythm, epicardial, and endocardial ventricular pacing (70 records in total). Body surface and cardiac electrode positions were determined and registered using magnetic resonance imaging. Epicardial potentials were reconstructed during ventricular activation using experiment-specific magnetic resonance imaging–based thorax models, with homogeneous or inhomogeneous (lungs, skeletal muscle, fat) electrical properties. Coupled finite/boundary element methods and a meshless approach based on the method of fundamental solutions were compared. Inverse mapping underestimated epicardial potentials >2-fold (
P
<0.0001).

RESULTS:
Mean correlation coefficients for reconstructed epicardial potential distributions ranged from 0.60±0.08 to 0.64±0.07 across all methods. Epicardial electrograms were recovered with reasonable fidelity at ≈50% of sites (median correlation coefficient, 0.69–0.72), but variation was substantial. General activation spread was reproduced (median correlation coefficient, 0.72–0.78 for activation time maps after spatio-temporal smoothing). Epicardial foci were identified with a median location error ≈16 mm (interquartile range, 9–29 mm). Inverse mapping with meshless method of fundamental solutions was better than with finite/boundary element methods, and the latter were not improved by inclusion of inhomogeneous torso electrical properties.

Conclusions:
Inverse potential mapping provides useful information on the origin and spread of epicardial activation. However the spatio-temporal variability of recovered electrograms limit resolution and must constrain the accuracy with which arrhythmia circuits can be identified independently using this approach.
Electronic Cigarette Prevalence and Patterns of Use in Adults with a History of Cardiovascular Disease in the United States
Authors: Stokes Andrew , Collins Jason M. , Berry Kaitlyn M. , Reynolds Lindsay M. , Fetterman Jessica L. , Rodriguez Carlos J. , Siegel Michael B. , Benjamin Emelia J. 
Published: April 2018

Background

Characterizing electronic cigarette (e‐cigarette) use patterns is important for guiding tobacco regulatory policy and projecting the future burden of tobacco‐related diseases. Few studies have examined patterns of e‐cigarette use in individuals with cardiovascular disease (
CVD
).

Methods and Results

We examined e‐cigarette use in adults aged 18 to 89 years with a history of
CVD
, using data from the 2014 National Health Interview Survey. We investigated associations between ever and current e‐cigarette use and smoking with multivariable logistic regression. In a secondary analysis, we modeled the association between e‐cigarette use and a quit attempt over the past year. Former smokers with
CVD
who quit smoking within the past year showed 1.85 (95% confidence interval, 1.03, 3.33) times the odds of having ever used e‐cigarettes as compared with those who reported being “some days” current smokers. Current smokers who attempted to quit smoking within the past year showed significantly increased odds of ever having used e‐cigarettes (odds ratio, 1.70; 95% confidence interval, 1.25, 2.30) and currently using e‐cigarettes (odds ratio, 1.97; 95% confidence interval, 1.32, 2.95) as compared with smokers who had not attempted to quit over the past year.

Conclusions

Individuals with
CVD
who recently quit smoking or reported a recent quit attempt were significantly more likely to use e‐cigarettes than current smokers and those who did not report a quit attempt. Our findings may indicate that this population is using e‐cigarettes as an aid to smoking cessation. Characterizing emerging e‐cigarette use behaviors in adults with
CVD
may help to inform outreach activities aimed at this high‐risk population.
Introduction to ‘Theodor W. Adorno on Marx and the Basic Concepts of Sociological Theory. From a Seminar Transcript in the Summer Semester of 1962’
Authors: O’Kane Chris 
Published: April 2018

AbstractThis introduction outlines the importance that Hans-Georg Backhaus’s transcript of Adorno’s 1962 seminar on ‘Marx and the Basic Concepts of Sociological Theory’ has for shedding light on the relationship between Adorno’s critical theory and the critique of political economy. PartIsignals the importance of the seminar by assaying the Anglophone scholarship on Adorno. PartIIcontextualises the seminar in the development of his thought. PartsIIIandIVfocus on what the transcript tells us about Adorno’s interpretation of Marx and the importance this interpretation held for Adorno’s critical social theory. PartVpoints to the influence this interpretation of the critique of political economy had on the formation of the New German Reading of Marx.
Clouds over the Southern Ocean as Observed from the R/V Investigator during CAPRICORN. Part II: The Properties of Nonprecipitating Stratocumulus
Authors: Mace Gerald G. , Protat Alain 
Published: April 2018

AbstractThe properties of clouds derived from measurements collected using a suite of remote sensors on board the Australian R/V Investigator during a 5-week voyage into the Southern Ocean during March and April 2016 are examined. Based on the findings presented in a companion paper (Part I), we focus our attention on a subset of marine boundary layer (MBL) clouds that form a substantial portion of the cloud-coverage fraction. We find that the MBL clouds that dominate the coverage fraction tend to occur in decoupled boundary layers near the base of marine inversions. The thermodynamic conditions under which these clouds are found are reminiscent of marine stratocumulus studied extensively in the subtropical eastern ocean basins except that here they are often supercooled with a rare presence of the ice phase, quite tenuous in terms of their physical properties, rarely drizzling, and tend to occur in migratory high pressure systems in cold-air advection. We develop a simple cloud property retrieval algorithm that uses as input the lidar-attenuated backscatter, the W-band radar reflectivity, and the 31-GHz brightness temperature. We find that the stratocumulus clouds examined have water paths in the 15–25 g m−2 range, effective radii near 8 μm, and number concentrations in the 20 cm−3 range in the Southern Ocean with optical depths in the range of 3–4. We speculate that addressing the high bias in absorbed shortwave radiation in climate models will require understanding the processes that form and maintain these marine stratocumulus clouds in southern mid- and high latitudes.
Relationships between Extreme Rain Rates and Convective Intensities from the Perspectives of TRMM and WSR-88D Radars
Authors: Gingrey Alexandria , Varble Adam , Zipser Edward 
Published: April 2018

AbstractTRMM PR 2A25, version 7 (V7), retrievals of reflectivity Z and rainfall rate R are compared with WSR-88D dual-polarimetric S-band radar data for 28 radars over the southeastern United States after matching their horizontal resolution and sampling. TRMM Ku-band measurements are converted to S-band approximations to more directly compare reflectivity estimates. Rain rates are approximated from WSR-88D data using the CSU–hydrometeor identification rainfall optimization (HIDRO) algorithm. Tropics-wide TRMM retrievals confirm previous findings of a low overlap fraction between extreme convective intensity, as approximated by the maximum 40-dBZ height, and extreme near-surface rain rates. WSR-88D data also confirm this low overlap but show that it is likely higher than TRMM PR retrievals indicate. For maximum 40-dBZ echo heights that extend above the freezing level, mean WSR-88D reflectivities at low levels are approximately 2 dB higher than TRMM PR reflectivities. Higher WSR-88D-retrieved rain rates for a given low-level reflectivity combine with these higher low-level reflectivities for a given maximum 40-dBZ height to produce rain rates that are approximately double those retrieved by the TRMM PR for maximum 40-dBZ heights that extend above the freezing level. TRMM PR path-integrated attenuation, and WSR-88D specific differential phase, differential reflectivity, and hail fraction indicate that the TRMM PR 2A25 V7 algorithm is possibly misidentifying low–midlevel hail and/or graupel as greater attenuating liquid, or vice versa. This misidentification, coupled with underestimation of path-integrated attenuation caused by nonuniform beamfilling and higher rain rates produced by specific differential phase (KDP)–R than Z–R relationships, results in low-biased 2A25 V7 rain rates in intense convection.
Prediction of haematocrit in dried blood spots from the measurement of haemoglobin using commercially available sodium lauryl sulphate
Authors: Richardson G , Marshall D , Keevil BG 
Published: April 2018

Background When preparing dried blood spots (DBSs), haematocrit (Hct) can affect the ability of the blood to spread through the filter paper, thus resulting in varying quantities of sample being measured when fixed subpunches of the DBSs are taken. It may be important to predict the sample Hct to correct volume differences. Methods Blood (10  µL) was applied to Perkin Elmer 226® paper. The samples ( n = 165) were allowed to dry for 24 h, and the entire blood spots were cut out. Subpunch analysis was also performed on blood spots prepared from 75  µL EDTA blood, taking 6 mm subpunches centrally and peripherally from the spots ( n = 59). The spots were eluted with 100  µL water, and a 10  µL aliquot of lysate was added to sulfolyser reagent (80  µL) in a microtitre plate. Hb was measured at 550 nm using an ELISA plate reader. DBS samples were compared against blood samples measured on a routine Sysmex XN-9000 analyser. Results The Passing and Bablock regression showed Hct (DBS-predicted) = 0.99 Hct (Sysmex) −0.02, R2 = 0.87. Intra-assay imprecision measured at Hct values of 0.27, 0.40 and 0.52, gave CVs of 4.1%, 2.8% and 4.2%, respectively. Inter-assay imprecision showed CVs of 6.2%, 5.2% and 4.2%, respectively. DBS samples were stable for up to two days at 60℃, one month at room temperature and six months at 4℃. Conclusion This method provides a simple and fast estimation of predicted Hct in dried blood spots.
Understanding Human Error in Naval Aviation Mishaps
Authors: Miranda Andrew T. 
Published: April 2018

Objective: To better understand the external factors that influence the performance and decisions of aviators involved in Naval aviation mishaps. Background: Mishaps in complex activities, ranging from aviation to nuclear power operations, are often the result of interactions between multiple components within an organization. The Naval aviation mishap database contains relevant information, both in quantitative statistics and qualitative reports, that permits analysis of such interactions to identify how the working atmosphere influences aviator performance and judgment. Method: Results from 95 severe Naval aviation mishaps that occurred from 2011 through 2016 were analyzed using Bayes’ theorem probability formula. Then a content analysis was performed on a subset of relevant mishap reports. Results: Out of the 14 latent factors analyzed, the Bayes’ application identified 6 that impacted specific aspects of aviator behavior during mishaps. Technological environment, misperceptions, and mental awareness impacted basic aviation skills. The remaining 3 factors were used to inform a content analysis of the contextual information within mishap reports. Teamwork failures were the result of plan continuation aggravated by diffused responsibility. Resource limitations and risk management deficiencies impacted judgments made by squadron commanders. Conclusion: The application of Bayes’ theorem to historical mishap data revealed the role of latent factors within Naval aviation mishaps. Teamwork failures were seen to be considerably damaging to both aviator skill and judgment. Application: Both the methods and findings have direct application for organizations interested in understanding the relationships between external factors and human error. It presents real-world evidence to promote effective safety decisions.
Cleft Care of Internationally Adopted Children From China
Authors: Kaye Alison , Che Columbine , Chew William L. , Stueve Elizabeth A. , Jiang Shao 
Published: April 2018

Objective: To quantify a population of international adoptees from China with cleft lip and/or palate to assess presentations and team management practices. Design: Single institution retrospective. Patients: One hundred one patients with cleft lip and/or palate and history of international adoption from China. Results: Forty-nine males and 52 females were adopted from 2001 to 2014. Median age at arrival was 26 months. A total of 88.1% had a combined cleft lip and palate: 59 unilateral, 30 bilateral. Only 4 patients had isolated cleft palate. A total of 85.6% had cleft lip repair before adoption; 41.6% had both cleft lip and palate repairs in China. A total of 14.9% of adoptees had no prior surgery. In China, median age at lip repair was 10 months, and palate repair was 19 months. Once in the United States, lip repair was at 24 months and palate repair at 24 months. Eighty-three revision surgeries were performed. A total of 79.2% of children demonstrated moderate to severe articulation disorders. A total of 36.6% had velopharyngeal insufficiency with hypernasal speech. Forty percent required palatal revision surgery to achieve normal resonance. Fifty seven percent of patients presented with concomitant medical issues but less than 10% with global delays or autism. Conclusions: Chinese adoptees have more complex presentations and delayed surgical care compared to their domestic counterparts. Engaging prospective families starting before adoption helps to manage expectations. Long-range planning, timely surgery, aggressive therapy, and close careful follow-up can mitigate some of these differences. Speech and language problems including articulation disorders, expressive delays, and hypernasality are frequent and can persist despite interventions.
Influence of the Vibralung Acoustical Percussor on pulmonary function and sputum expectoration in individuals with cystic fibrosis
Authors: Wheatley Courtney M. , Baker Sarah E. , Daines Cori M. , Phan Hanna , Martinez Marina G. , Morgan Wayne J. , Snyder Eric M. 
Published: April 2018

Background: The Vibralung Acoustical Percussor is a new airway clearance therapy (ACT) utilizing intrapulmonary sound waves in addition to positive expiratory pressure (PEP). We evaluated the safety of the Vibralung and collected preliminary data on its ability to mediate sputum expectoration in individuals with cystic fibrosis (CF). Methods: Over two separate studies, 10 and 11 mild to moderate CF patients were recruited for study I and II, respectively. Study I: Vibralung was used for 20 min with either no sound (NS: PEP only) or sound (S: PEP and sound) on randomized visits. Pulmonary function, diffusion capacity of the lungs for carbon monoxide and nitric oxide (DLCO/DLNO), symptoms, and peripheral oxygen saturation (SpO2) were measured at baseline and at 1 and 4 h post treatment. Expectorated sputum was collected over 4 h post treatment. Study II: over 5 days of in-hospital therapy, the Vibralung or vibratory vest therapy (Vest) were used for two therapy sessions per day, with sputum collected for 20 min following each therapy and pulmonary function accessed pre and post each 5-day period (days 1–5 or 7–11) in a randomized crossover design. Results: Vibralung usage resulted in no change from baseline to 4 h post in pulmonary function, SpO2 or symptoms ( p > 0.05). At 4 h post therapy, the DLCO- and DLNO-derived measure of alveolar–capillary unit function (DM/ VC) showed improvement (DM/ VC = 12.5 ± 5.5 versus 7.3 ± 18.8% change, S versus NS) with no difference between S and NS ( p = 0.74). Sputum expectoration was similar between S and NS conditions (wet sputum = 10.5 ± 4.6 versus 9.9 ± 3.2 g, S versus NS, p = 0.25). There were no differences in the improvement in pulmonary function between Vibralung and Vest during either 5-day period during the hospital stay. Conclusions: Vibralung was well tolerated and caused no detrimental changes in pulmonary function metrics. The Vibralung appears to be a safe ACT in individuals with CF.
Performance of cooling materials and their composites in maintaining freezing temperature during irradiation and transportation of bone allografts
Authors: Ramalingam Saravana , Samsuddin Sharifah Mazni , Yusof Norimah , Mohd Suhaili , Hanafi Nurhafizatul Nadia , Min Ng Wuey , Mansor Azura 
Published: April 2018

Purpose: Bone allografts supplied by University Malaya Medical Centre Bone Bank are sterilized by gamma radiation at 25 kGy in dry ice (DI) to minimize radiation effects. Use of cheaper and easily available cooling materials, gel ice (GI) and ice pack (IP), was explored. Composites of DI and GI were also studied for the use in routine transportations and radiation process. Methods: (a) Five dummy bones were packed with DI, GI, or IP in a polystyrene box. The bone temperatures were monitored while the boxes were placed at room temperature over 96 h. Durations for each cooling material maintaining freezing temperatures below −40°C, −20°C, and 0°C were obtained from the bone temperature over time profiles. (b) Composites of DI (20, 15, 10, 5, and 0 kg) and GI were used to pack five dummy bones in a polystyrene box. The durations maintaining varying levels of freezing temperature were compared. Results: DI (20 kg) maintained temperature below −40°C for 76.4 h as compared to 6.3 h in GI (20 bags) and 4.0 h in IP (15 packs). Composites of 15DI (15 kg DI and 9 GI bags) and 10DI (10 kg DI and 17 GI bags) maintained the temperature below −40°C for 61 and 35.5 h, respectively. Conclusion: Composites of DI and GI can be used to maintain bones in deep frozen state during irradiation, thus avoiding radiation effects on biomechanical properties. Sterile frozen bone allograft with preserved functional properties is required in clinical applications.
An imaging-based treatment algorithm for posterior focal retinitis
Authors: Chawla Rohan , Tripathy Koushik , Temkar Shreyas , Venkatesh Pradeep , Kumar Atul 
Published: April 2018

Background: In this paper, our aim was to describe an imaging-based empirical approach for categorizing and initiating treatment of immunocompetent patients with posterior focal retinitis, prior to the availability of results of expensive laboratory investigations. Materials and methods: The hospital records of 13 patients with posterior focal retinitis were reviewed. Results: Of the 13 patients, 9 were women and 4 were men. The mean age was 24 ± 8 years. Based on similarities in clinical presentation and imaging, we categorized our cases into three groups with different first-line therapeutic strategies. In the first group, patients had presumed toxoplasmosis (treated with oral cotrimoxazole); in the second group, patients had presumed viral (herpetic) etiology (treated with oral valacyclovir); and in the third group, patients had presumed nonherpetic, nontoxoplasma retinitis (treated with oral doxycycline). Positive serology results included Rickettsia (two patients), Borrelia (one patient), Toxoplasma (two patients), and herpes simplex virus (one patient). Conclusion: An empirical approach for early initiation of therapy in retinitis cases based on imaging features is described.
Existence of weak solutions of stochastic delay differential systems with Schrödinger–Brownian motions
Authors: Sun Jianguo , Kou Liang , Guo Gang , Zhao Guodong , Wang Yong 
Published: April 2018

AbstractBy using new Schrödinger type inequalities appearing in Jiang and Usó (J. Inequal. Appl. 2016:233, 2016), we study the existence of weak solutions of stochastic delay differential systems with Schrödinger–Brownian motions.
Pathways to Recovery: development and evaluation of a cognitive–behavioural therapy in-patient treatment programme for adults with anorexia nervosa
Authors: Brown Andrea , Jenkinson Richard , Coakes Julia , Cockfield Annette , O'Brien Tish , Hall Louise 
Published: April 2018

Aims and methodA cognitive–behavioural therapy in-patient treatment model for adults with severe anorexia nervosa was developed and evaluated, and outcomes were compared with the previous treatment model and other published outcomes from similar settings.ResultsThis study showed the Pathways to Recovery outcomes were positive in terms of improvements in body mass index and psychopathology.Clinical implicationsAdults with anorexia nervosa can achieve good outcomes despite longer illness duration and comorbidities.Declaration of interestA.B., A.C. and L.H. work at The Retreat where the Pathways to Recovery were developed.
Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism
Authors: Widowati Esti Wahyu , Ernst Sabrina , Hausmann Ralf , Müller-Newen Gerhard , Becker Walter 
Published: April 2018

ABSTRACT
Haploinsufficiency of DYRK1A is a cause of a neurodevelopmental syndrome termed mental retardation autosomal dominant 7 (MRD7). Several truncation mutations, microdeletions and missense variants have been identified and result in a recognizable phenotypic profile, including microcephaly, intellectual disability, epileptic seizures, autism spectrum disorder and language delay. DYRK1A is an evolutionary conserved protein kinase which achieves full catalytic activity through tyrosine autophosphorylation. We used a heterologous mammalian expression system to explore the functional characteristics of pathogenic missense variants that affect the catalytic domain of DYRK1A. Four of the substitutions eliminated tyrosine autophosphorylation (L245R, F308V, S311F, S346P), indicating that these variants lacked kinase activity. Tyrosine phosphorylation of DYRK1A-L295F in mammalian cells was comparable to wild type, although the mutant showed lower catalytic activity and reduced thermodynamic stability in cellular thermal shift assays. In addition, we observed that one variant (DYRK1A-T588N) with a mutation outside the catalytic domain did not differ from wild-type DYRK1A in tyrosine autophosphorylation, catalytic activity or subcellular localization. These results suggest that the pathogenic missense variants in the catalytic domain of DYRK1A impair enzymatic function by affecting catalytic residues or by compromising the structural integrity of the kinase domain.
This article has an associated First Person interview with the first author of the paper.