bluuebunny/crossref_metadata_2025_split huggingface dataset:
The activity-dependent transcription factor Npas4 regulates IQSEC3 expression in somatostatin interneurons to mediate anxiety-like behavior
Authors: Kim Seungjoon , Park Dongseok , Kim Jinhu , Lee Dongsoo , Kim Dongwook , Kim Hyeonho , Hong Sookyung , Jeon Jongcheol , Kim Jaehoon , Cheong Eunji , Um Ji Won , Ko Jaewon 
Published: June 2019

AbstractOrganization of mammalian inhibitory synapses is thought to be crucial for normal brain functions, but the underlying molecular mechanisms have been still incompletely understood. IQSEC3 (IQ motif and Sec7 domain 3) is a guanine nucleotide exchange factor for ADP-ribosylation factor (ARF-GEF) that directly interacts with gephyrin. Here, we show that GABAergic synapse-specific transcription factor, Npas4 (neuronal PAS domain protein 4) directly binds to the promoter of Iqsec3 and regulates its transcription. Strikingly, an enriched environment (EE) induced Npas4 upregulation and concurrently increased IQSEC3 protein levels specifically in mouse CA1 stratum oriens layer somatostatin (SST)-expressing GABAergic interneurons, which are compromised in Npas4-knockout (KO) mice. Moreover, expression of wild-type (WT) IQSEC3, but not a dominant-negative (DN) ARF-GEF–inactive mutant, rescued the decreased GABAergic synaptic transmission in Npas4-deficient SST interneurons. Concurrently, expression of IQSEC3 WT normalized the altered GABAergic synaptic transmission in dendrites, but not soma, of Npas4-deficient CA1 pyramidal neurons. Furthermore, expression of IQSEC3 WT, but not IQSEC3 DN, in SST-expressing interneurons in CA1 SST Npas4-KO mice rescued the altered anxiety-like behavior. Collectively, our results suggest that IQSEC3 is a key GABAergic synapse component that is directed by Npas4 activity- and ARF activity-dependent gene programs in SST-expressing interneurons to orchestrate the functional excitation-to-inhibition balance.
A DNA-based synthetic apoptosome
Authors: Rosier Bas J.H.M. , Markvoort Albert J. , Gumí-Audenis Berta , Roodhuizen Job A.L. , den Hamer Anniek , Brunsveld Luc , de Greef Tom F.A. 
Published: June 2019

AbstractLiving cells are able to regulate key cellular processes by physically assembling signaling components on dedicated molecular platforms. The spatial organization of proteins in these higher-order signaling complexes facilitates proximity-driven activation and inhibition events, allowing tight regulation of the flow of information. Here, we employ the programmability and modularity of DNA origami as a controllable molecular platform for studying protein-protein interactions involved in intracellular signaling. Specifically, we engineer a synthetic, DNA origami-based version of the apoptosome, a large multi-protein signaling complex that regulates apoptosis by co-localization of multiple caspase-9 monomers. Ourin vitrocharacterization using both wildtype caspase-9 monomers and inactive mutants tethered to a DNA origami platform directly demonstrates that enzymatic activity is induced by proximity-driven dimerization with asymmetric, half-of-sites reactivity. Additionally, experimental results supported by a detailed thermodynamic model reveal a multivalent activity enhancement in tethered caspase-9 oligomers of three and four enzymes, partly originating from a statistical increase in the number of active catalytic units in higher-order enzyme clusters. Our results offer fundamental insights in caspase-9 activity regulation and demonstrate that DNA origami provides a modular platform to construct and characterize higher-order signaling complexes. The engineered DNA-based protein assembly platform has the potential to be broadly applied to inform the function of other important multi-enzyme assemblies involved in inflammation, innate immunity, and necrosis.
Multidisciplinary impact – the arts join informal STEM programs
Authors: Tretola Betsy , Coupey Eloise , Meamber Laurie 
Published: June 2019

Purpose
Middle school participants in the USA attending an on-campus university informal science program indicate an increase in interest toward careers and disciplines in STEM or STEAM (science, technology, engineering and mathematics and the arts). Parents or guardians confirm the change. The paper aims to discuss this issue.

Design/methodology/approach
Participants attended “inquiry-based” lectures by scientists and “hands-on” activities conducted by volunteers on campus at a public university over four months, four Saturdays. Participants completed surveys before each lecture and guardians completed surveys afterwards.

Findings
Interest increased significantly according to paired samples t-tests for each STEM discipline for students who reported low interest on the initial pre-lecture survey. There was a significant linear improvement in interests in engineering using a repeated measures general linear model. Guardians or parents reported that they observed a higher interest in STEM disciplines resulting in more technical-related interaction among peers and within the family.

Social implications
Findings support STEM with arts “out-of-school” programs sponsored by museums, corporations, government, higher education and others. Inclusion of the “hands-on” activities, some with arts content, to the science and technical learning appears to spark enthusiasm.

Originality/value
The value is multidisciplinary. The theory of reasoned action from social psychology, sociology, along with related research in science education and the arts are synthesized. Informal extracurricular experiences sustained and improved interests in the disciplines and careers on which the formal educational career pipeline can build.
Oil, gold, stones: cultural value in Italian cultural policy
Authors: Borchi Alice 
Published: June 2019

Purpose
The purpose of this paper is to understand the concept of cultural value promoted by the Italian government between 2008 and 2018. Furthermore, it aims at setting the scope for further research and debate on the issue of cultural value in Italian cultural policy by questioning market-driven understanding of value.

Design/methodology/approach
In order to do so, it examines the rhetoric of Italian policymakers, with a particular focus on the people who have covered the role of Ministry for Cultural Assets and Activities over this 10-year span, and the policies they have implemented. The various nuances of the concept of valorizzazione are studied by analysing different pathways employed by the Italian government and the values underpinning them, with a particular focus on the abandonment of heritage sites.

Findings
What emerges from this research is the centrality of the economic value of culture; however, the economic impact of Italian cultural assets is always presented as a potential that has to be unlocked by implementing policies of valorizzazione, a term that has a double meaning of promotion and exploitation (Belfiore, 2006).

Originality/value
This paper presents an original approach to understanding the formation and promotion of cultural value at the level of governmental policy in the context of contemporary cultural policy in Italy. In particular, it evidences how the centrality of the economic value of culture has remained unscathed despite the rapid change of governments that has characterised Italian politics in the last 10 years.
The death of arts marketing: a paradigm shift from consumption to enrichment
Authors: Walmsley Ben 
Published: June 2019

PurposeThe purpose of this paper is to demonstrate how researchers in the field of arts marketing are gradually abandoning the traditional marketing concept in order to respond to established and emerging modes of audience engagement.Design/methodology/approachThe study is based on a comprehensive content analysis of the past three decades of journal articles related to arts marketing.FindingsThe results of the content analysis highlight that a paradigm shift in arts marketing has occurred over the past two decades, from an overriding focus on neoliberal processes of consumption towards a relational, humanistic approach, which aims to enrich audiences and interrogate the wider value and impact of their arts experiences.Research limitations/implicationsThe logical conclusion to be derived from this paradigmatic shift is that “arts marketing” is increasingly becoming an outmoded misnomer, which suggests the need for a fundamental reassessment of the traditional arts marketing concept.Practical implicationsIn order to develop meaningful relationships with audiences, arts and cultural organisations should prioritise the long-term relational approaches offered by audience engagement over short-term tactical activities such as segmentation and promotion.Originality/valueThe paper advocates a radical reconceptualization of the field that would replace the transactional 4P model with a relational 4E model, derived from an adoption of theories, processes and practices related to the elements of experience, exchange, environment and engagement.
Paternalistic leadership and employee well-being: a moderated mediation model
Authors: He Guohua , An Ran , Hewlin Patricia Faison 
Published: June 2019

PurposeThis paper aims to explore the psychological mechanism in the relationship between paternalistic leadership (PL) and employee well-being (EWB) in cross-cultural nonprofit organizations. It also aims to further promote the integration of research on PL and self-concept by examining the relationship between PL and collective self-concept (CSC).Design/methodology/approachData were collected on 72 supervisors and 233 expatriate Chinese teachers from 42 Confucius Institutes and 15 Confucius classrooms in Canada and the USA.FindingsPL has a significant effect on EWB. Benevolent and moral leadership are positively related to CSC, while authoritarian leadership is negatively related to CSC. CSC mediates the relationship between PL and EWB. Furthermore, employees’ cross-cultural adaptability positively moderates the relationship between CSC and EWB; the indirect effect between PL and EWB via CSC is stronger for employees with stronger cross-cultural adaptability.Originality/valueThis is the first study that has examined the psychological mechanism under which PL affects EWB in cross-cultural nonprofit organizations. It contributes to the integration of research on PL and CSC by examining its relationship for the first time. It provides important implications for improving the well-being of expatriate employees in cross-cultural organizations.
Carnegie in Australia: philanthropic power and public education in the early twentieth century
Authors: Green Bill 
Published: June 2019

PurposeThe purpose of this paper is to outline a reconceptualised view of public education, with specific reference to early twentieth-century Australia, and to revisit the significance of the Carnegie Corporation of New York in this period. Further, in this regard, the paper proposes a neo-Foucaultian notion of philanthropic power, as an explanatory and analytical principle, with possible implications for thinking anew about the role and influence of American philanthropic organisations in the twentieth century.Design/methodology/approachThe paper draws on mainly secondary sources but also works with primary sources gathered from relevant archives, including that of the Australian Council for Educational Research (ACER).FindingsThe paper concludes that the larger possibilities associated with the particular view of public education outlined here, referring to both public school and public libraries, were constrained by the emergence and consolidation of an increasingly professionalised view of education and schooling.Research limitations/implicationsThe influence of the Carnegie Corporation of New York on early twentieth-century Australian education has been increasingly acknowledged and documented in recent historical research. More recently, Carnegie has been drawn into an interdisciplinary perspective on philanthropy and public culture in Australia. This paper seeks to add to such work by looking at schools and libraries as interconnected yet loosely coupled aspects of what can be understood as, in effect, a re-conceived public education, to a significant degree sponsored by the Corporation.Originality/valueThe paper draws upon but seeks to extend and to some extent re-orient existing historical research on the relationship between Australian education and the Carnegie Corporation of New York. Its originality lies in its exploration of a somewhat different view of public education and the linkage it suggests in this regard with a predominantly print-centric public culture in Australia, in the first half of the twentieth century.
Hybrid nanofluid flow and heat transfer over a nonlinear permeable stretching/shrinking surface
Authors: Waini Iskandar , Ishak Anuar , Pop Ioan 
Published: June 2019

Purpose
This paper aims to investigate the steady flow and heat transfer of a Cu-Al2O3/water hybrid nanofluid over a nonlinear permeable stretching/shrinking surface with radiation effects. The surface velocity condition is assumed to be of the power-law form with an exponent of 1/3. The governing equations of the problem are converted into a system of similarity equations by using a similarity transformation.

Design/methodology/approach
The problem is solved numerically using the boundary value problem solver (bvp4c) in Matlab software. The results of the skin friction coefficient and the local Nusselt number as well as the velocity and temperature profiles are presented through graphs and tables for several values of the parameters. The effects of these parameters on the flow and heat transfer characteristics are examined and discussed.

Findings
Results found that dual solutions exist for a certain range of the stretching/shrinking and suction parameters. The increment of the skin friction coefficient and reduction of the local Nusselt number on the shrinking sheet is observed with the increasing of copper (Cu) nanoparticle volume fractions for the upper branch. The skin friction coefficient and the local Nusselt number increase when suction parameter is increased for the upper branch. Meanwhile, the temperature increases in the presence of the radiation parameter for both branches.

Originality/value
The problem of Cu-Al2O3/water hybrid nanofluid flow and heat transfer over a nonlinear permeable stretching/shrinking surface with radiation effects is the important originality of the present study where the dual solutions for the flow reversals are obtained.
Permeability determination in tight rock sample using novel method based on partial slip modelling and X-ray tomography data
Authors: Madejski Paweł , Krakowska Paulina , Puskarczyk Edyta , Habrat Magdalena , Jędrychowski Mariusz 
Published: June 2019

Purpose
The purpose of the paper was the application of computational fluid dynamics (CFD) techniques in fluid flow using Maxwell’s equation for partial slip modelling, estimating the flow parameters, and selecting tangential momentum accommodation coefficient (TMAC) for tight rock samples in permeability calculations.

Design/methodology/approach
The paper presents a numerical analysis of fluid flow in a low-porosity rock sample by using CFD. Modelling results allowed to determine mass flow rates in a rock sample and to calculate permeability values using a modified Darcy’s equation. Three-dimensional (3D) geometrical model of rock sample generated using computed X-ray tomography was used in the analysis. Steady-state calculations were carried out for defined boundary conditions in the form of pressure drop. The simulations were applied taking into account the slip phenomenon described by Maxwell’s slip model and TMAC.

Findings
Values of permeability were calculated for different values of TMAC, which vary from 0 to 1. Results in the form of gas mass flow rates were compared with the measured value of permeability for rock sample, which confirmed the high accuracy of the presented model.

Practical implications
Calculations of fluid flow in porous media using CFD can be used to determine rock samples’ permeability. In slip flow regime, Maxwell’s slip model can be applied and the empirical value of TMAC can be properly estimated.

Originality/value
This paper presents the usage of CFD, Maxwell’s equation for partial slip modelling, in fluid flow mechanism for tight rock samples. 3D geometric models were generated using created pre-processor (poROSE software) and applied in the raw form for simulation.
A systematic literature review of emotional labor research from the hospitality and tourism literature
Authors: Lee Lindsey , Madera Juan M. 
Published: June 2019

PurposeThe purpose of this paper is to provide an exhaustive review of emotional labor research from the hospitality and tourism literature by outlining the theories, the antecedents and the outcomes of emotional labor, as well as the underlying mechanisms (i.e. mediators and moderators) of emotional labor.Design/methodology/approachThis study provides a qualitative and critical review of emotional labor research from the hospitality and tourism literature, providing insights into the trends and gaps in the literature.FindingsThe conservation of resources theory and affective event theory are the two most common theories in the reviewed literature. Emotional intelligence and personality are the most commonly investigated antecedents while burnout and job satisfaction are the most investigated outcomes of emotional labor. Stress and burnout are the most examined mediators of emotional labor and subsequent outcomes, such as commitment, turnover intentions and well-being. Moderators include leader-member exchange, job position, gender and climate of authenticity.Practical implicationsFour major gaps for research and practice are identified as follows: the lack of an overarching theoretical framework; inconsistency in how emotional labor is defined and measured; the vast majority of emotional labor studies are cross-sectional studies; and no research examines potential interventions to help service employees engage in effective emotional labor strategies.Originality/valueThis review offers a model providing a comprehensive framework that outlines the various antecedents, outcomes, mediators and moderators of emotional labor and corresponding theories for future research.
Event attendance motives, host city evaluation, and behavioral intentions
Authors: Jiang Yangyang , Chen Ning (Chris) 
Published: June 2019

Purpose
This paper aims to examine the event attendance motives and the underlying mechanism through which event attendance motives influence positive word-of-mouth (PWOM) and revisit intentions. It also investigates how event attendance motives differ by gender.

Design/methodology/approach
A self-completed survey administered in English among visitors to the 2016 Olympic Games generated 230 valid responses. Partial least squares-based structural equation modeling was applied to test research hypotheses.

Findings
Event attendance motives of esthetics and escape positively influence host city evaluation. Host city evaluation positively influences PWOM and revisit intentions. Host city evaluation mediates the relationship between event attendance motives (esthetics and escape) and behavioral intentions (PWOM and revisit intentions). Male Olympic tourists show significantly lower means in the motives of social bond and escape when compared with female Olympic tourists.

Originality/value
This study adds to the body of knowledge concerning Olympic tourists, their motives and behavioral intentions. Research findings indicate that event attendance motives influence PWOM and revisit intentions through the mediating effect of host city evaluation. Considering the noticeable paucity of gender analysis weakens the understanding of the Olympic tourist behavior, this study contributes to the literature by examining gender differences in Olympic attendance motives.
Triadic mentoring in early childhood teacher education: the role of relational agency
Authors: Ben-Harush Aya , Orland-Barak Lily 
Published: June 2019

Purpose
Current approaches to early childhood teacher education have moved from a view of student–teacher training as interactions involving one novice and one expert, to a process that demands resources and engagement of several professional players while mediating students’ learning in practice. The purpose of this paper is to examine the impact of a triadic mentoring model of a university–school collaboration (“Academia–Classroom”) on student teachers’ (STs) learning in the context of early childhood education in Israel. Eight mentoring triads were formed in six kindergartens. Each mentoring triad was comprised of the ST, a cooperating teacher and the college supervisor. This paper focuses on three representative triads of the eight that were studied.

Design/methodology/approach
The in-depth study adopted qualitative methodology including three complementary data-collection sources: observations of the STs working with children in the kindergarten; observations and recordings of the triadic mentoring conversations following the observations; in-depth interviews with each participant in the mentoring triad. Data were analyzed using an interpretative framework developed for the study, which combined elements from Engestrom’s cultural historical activity theory, Gee’s building tasks and Edward’s relational agency.

Findings
The research identified three major patterns of interaction operating in the mentoring triad that promoted or hindered the learning process of early childhood education students: dissonant, harmonic and argumentative. The way in which relational agency developed in the triads was found to be the most significant aspect of students’ learning process.

Originality/value
The patterns of interaction identified shed light on new aspects of relational agency, thus offering additional interpretative lenses for examining how relational agency operates in ST mentored learning processes. These new identified patterns have practical implications for the design of mentoring frameworks in early childhood teacher education.
Logistics service triad for household waste: consumers as co-producers of sustainability
Authors: Halldórsson Árni , Altuntas Vural Ceren , Wehner Jessica 
Published: June 2019

Purpose
The purpose of this paper is to explore the sustainability of waste supply chains regarding the energy efficiency of first-mile waste collection systems and quality of waste. Roles of actors in the waste service triad are considered, particularly focusing on households.

Design/methodology/approach
Primary data are collected from respondents including municipality officers, waste service providers (WSPs) and households through brainstorming sessions, semi-structured interviews, site visits and a focus group. Secondary data are collected from official reports for validation.

Findings
Findings reveal tension between the energy efficiency of waste collection logistics and the quality of waste collected. Households are co-producers of logistic services providing important inputs in the form of sorting and moving waste and raw materials into new cycles of goods circulating in logistics systems. Other actors in the logistics service triad are the municipality as regulator and the WSP acting as a reverse-logistics service provider.

Practical implications
This study provides principles for policymakers and practitioners to evaluate the energy efficiency of waste management options, considering the quality of waste. Also, “logistics services” and “quality of waste” as concepts might provoke new thoughts on how to involve the consumer in resource recovery.

Originality/value
Few studies have focused on the end-consumer’s role in waste supply chains. By considering waste as a resource and the consumer as the supplier of this input, this study provides a new way to think about logistics services for waste collection.