bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate
Authors: Qin Xu‐Jie , Rauwolf Tyler J. , Li Pan‐Pan , Liu Hui , McNeely James , Hua Yan , Liu Hai‐Yang , Porco John A. 
Published: January 2019

AbstractRhodomyrtusials A–C, the first examples of triketone‐sesquiterpene meroterpenoids featuring a unique 6/5/5/9/4 fused pentacyclic ring system were isolated from Rhodomyrtus tomentosa, along with several biogenetically‐related dihydropyran isomers. Two bis‐furans and one dihydropyran isomer showed acetylcholinesterase (AChE) inhibitory activity. Structures of the isolates were unambiguously established by a combination of spectroscopic data, ECD analysis, and total synthesis. Bioinspired total syntheses of six isolates were achieved in six steps utilizing a reactive enetrione intermediate generated in situ from a readily available hydroxy‐endoperoxide precursor.
The dynamic behaviour of a large‐scale 250‐mm hydrocyclone: A CFD study
Authors: Vakamalla Teja Reddy , Mangadoddy Narasimha 
Published: January 2019

AbstractThe fluctuating feed solid contents usually cause instationarities in industrial hydrocyclone separation. This demands a controlling mechanism for stabilizing the separation effect. Understanding the transitional/dynamic behaviour is necessary to design such control mechanisms. In this context, the present paper is aimed to understand the dynamic behaviour of a large‐scale 250‐mm hydrocyclone in terms of air core development and solid concentration distributions using the modified mixture model coupled with large eddy simulation turbulence model. Numerically predicted two‐phase flow field data is validated against laser Doppler velocimetry data at two axial positions. A close agreement is found between the modified mixture model predicted particle classification curve and experimental data. Longer residence time is observed with near cut size particle compared to the and fine size particles. Further, the analysis of the equilibrium radius of different solid particles inside the cyclone in the presence of turbulence is compared with the classical Kelsall experiments and observed that the classification of particles influenced by both the turbulent dispersion and the centrifugal force. Finally, the effect of feed solids concentration (10–50 wt%) on the hydrocyclone performance and particle segregation is also undertaken in this study.
Fluidizing effects of polymers with various anchoring groups in cement pastes and their sensitivity to environmental temperatures
Authors: Tian Hongwei , Kong Xiangming , Sun Jiangbo , Wang Dongmin , Huang Chunlong 
Published: January 2019

ABSTRACTWe synthesized various polymers with different functional groups of ─COO−, ─SO3−, and ≡N+─ to study the impact of the environmental temperature (25, 50, and 80 °C) on the dispersing capability by measuring the fluidity of fresh cement paste, total organic carbon, ζ potential, and isothermal calorimetry. The results show that no adsorption was observed for the cement pastes containing acrylic acid, 2‐acrylamido‐2‐methyl propane sulfonic acid, and [3‐(methacryloylamino)propyl] trimethyl ammonium chloride, probably because of the trace amount of adsorption, whereas the fluidity of the pastes was indeed improved by the addition of these chemicals. Generally, for the polymers containing various functional groups, the adsorption capability was in the order ─COO− > ─SO3− > ≡N+─. The dispersing capability for the carboxylate superplasticizer was robust to the change in the temperature, whereas it was dramatically weakened by the increase in temperature for sulfonate superplasticizer, although the adsorption amount increased along with the temperature rise. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47494.
3‐[4′‐(Diethylboryl)phenyl]pyridine: Exclusive Crystallization of the Cyclic Tetramer
Authors: Wakabayashi Shigeharu , Sugiyama Natsu , Ohki Yasuhiro , Itoh Takahito , Kitagawa Toshikazu 
Published: January 2019

AbstractThe crystallization of 3‐[4′‐(diethylboryl)phenyl]pyridine (1), which formed a mixture of oligomers in solution with the cyclic trimer as a major component, in acetone at 0 °C afforded a cyclic tetramer that co‐crystallized with solvent molecules. Similarly, solutions of compound 1 in toluene at 10 °C and in benzene at 8 °C furnished the cyclic tetramer with the incorporation of toluene and benzene molecules, respectively, thus suggesting that the cyclic tetramer was the minor component. 13C CP/MAS NMR spectroscopy of precipitates of compound 1 suggested that precipitation from acetone and toluene each afforded mixtures of the cyclic trimer and the cyclic tetramer, whereas precipitation from benzene exclusively furnished the cyclic tetramer. Therefore, it appeared that crystallization readily shifted the equilibrium towards the cyclic tetramer in benzene. The thermodynamic parameters for the equilibrium between these two oligomers in [D6]benzene, as determined from a van′t Hoff plot, were ΔH°=−8.8 kcal mol−1 and ΔS°=−23.7 cal mol−1 K−1, which were coincident with previously reported calculations and observations.
Efficient Non‐doped Blue Fluorescent Organic Light‐Emitting Diodes Based on Anthracene–Triphenylethylene Derivatives
Authors: Liu Futong , Tao Yanchun , Li Jinyu , Liu Hui , He Xin , Du Chunya , Tang Xiangyang , Lu Ping 
Published: January 2019

AbstractThe development of efficient blue materials has been a continuous research topic in the field of organic light‐emitting diodes (OLEDs). In this paper, three aggregation‐induced emission enhancement active blue emitters, PIAnTPE, TPAAnTPE and CzAnTPE, are successfully synthesized by attaching a triphenylethylene unit and phenanthroimidazole/triphenylamine/carbazole moieties to the 9,10‐positions of anthracene, respectively. The three compounds exhibit good thermal stabilities, appropriate for the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) energy levels and display high photoluminescence quantum yields (PLQYs) of 65, 70 and 46 % in the solid state. Non‐doped blue devices using PIAnTPE, TPAAnTPE and CzAnTPE as the emitting layers show good electroluminescent performances, with the maximum external quantum efficiencies (EQEs) of 4.46, 4.13 and 4.04 %, respectively. More importantly, EQEs of all the three devices can be still retained when the luminescence reaches 1000 cd m−2, exhibiting quite small efficiency roll‐offs in the non‐doped OLEDs.
Continuous‐discrete filters for bearings‐only underwater target tracking problems
Authors: Radhakrishnan Rahul , Bhaumik Shovan , Tomar Nutan Kumar 
Published: January 2019

AbstractIn this work, we develop a continuous‐discrete shifted Rayleigh filter (CD‐SRF) and a continuous‐discrete sparse‐grid Gauss‐Hermite filter (CD‐SGHF) for a real‐life passive underwater bearings‐only target tracking problem. The stochastic difference equation describing the process model is derived from its continuous equivalent using Ito‐Taylor expansion of order 1.5. The performance of the proposed filters is compared in terms of root mean square error (RMSE), track divergence and computational time. For a fair comparison, popular filters like the unscented Kalman filter (UKF), cubature Kalman filter (CKF) and Gauss–Hermite filter (GHF) are implemented. The effect of initial uncertainty, measurement noise covariance and sampling time on filtering accuracy is also studied. Finally, RMSEs of all the filters are evaluated in comparison with the Cramer–Rao lower bound (CRLB). From simulation results, it was observed that CD filters performed with higher accuracy than their discrete equivalents, with CD‐SRF proving to be the most accurate among all the filters.
Contralateral surgery in patients scheduled for total thyroidectomy with initial loss or absence of signal during neural monitoring
Authors: Sitges-Serra A , Gallego-Otaegui L , Fontané J , Trillo L , Lorente-Poch L , Sancho J 
Published: January 2019

Abstract

Background
Staged total thyroidectomy has been advised to prevent bilateral recurrent laryngeal nerve paralysis when loss of the signal from neural monitoring is observed after dissection of the initial thyroid lobe. This is supported by expert opinion but hard evidence is lacking. A lost signal can return during surgery or, even if it persists, its positive predictive value is only in the range 60–70 per cent. The aim of the present study was to investigate the clinical outcome of patients in whom total thyroidectomy was performed following loss of signal after dissection of the first thyroid lobe.

Methods
This was a prospective observational study of adult patients scheduled for neural monitoring during total thyroidectomy. The prevalence of first-side absence or loss of signal was recorded. The contralateral thyroid lobe was approached routinely. The vagus and recurrent laryngeal nerves on the first side were retested during and at the end of the contralateral procedure.

Results
Some 462 patients were included. Loss (32 patients) or initial absence (8) of signal at dissection of the first thyroid lobe was noted in 40 patients (8·7 per cent). Total thyroidectomy was completed in 29 patients, and a change of surgical strategy adopted in 11 patients with benign disease. At retesting, 15 of 37 initially silent nerves recovered electromyographic signal after a mean(s.d.) interval of 30(14) min. Postoperative vocal cord palsy/paresis was demonstrated in 24 of 40 patients. One patient developed a bilateral paresis that could be managed conservatively.

Conclusion
After an absence or loss of signal of the recurrent laryngeal nerve following dissection of the first thyroid lobe, contralateral thyroidectomy can be performed safely, avoiding the expense, psychological burden and potential complications of a second procedure.
Internal enhancement of DNA damage by a novel bispecific antibody‐drug conjugate‐like therapeutics via blockage of mTOR and PD‐L1 signal pathways in pancreatic cancer
Authors: Cao Rui , Song Wenping , Ye Cheng , Liu Xiujun , Li Liang , Li Yi , Yao Hongjuan , Zhou Xiaofei , Li Liang , Shao Rongguang 
Published: January 2019

AbstractPancreatic ductal adenocarcinoma (PDAC) is a refractory malignant tumor with poor prognosis, limited chemotherapeutic efficacy, and only about 5% of 5‐year survival rate. We generated a dual‐targeting ligand‐based lidamycin (DTLL) to investigate its efficacy against pancreatic cancer after preparing its precursor, DTLP. DTLP was shown specifically binding to EGFR and HER2 on cell surface, followed by endocytosis into cytoplasm of pancreatic cancer cells. DTLL significantly promoted apoptosis and cell cycle arrest at G2/M stages and inhibited cell proliferation. Pancreatic tumors of either MIA‐paca‐2 cell line‐derived (CDX) or patient‐derived xenograft (PDX) mouse models were significantly regressed in response to DTLL. It suggested that DTLL might be a highly potent bispecific antibody‐drug conjugate (ADC)‐like agent for pancreatic cancer therapy. LDM is known to function as an antitumor cytotoxic agent by its induction of DNA damage in cancer cells, therefore, DTLL, as its derivative, also showed similar cytotoxicity. However, we found that DTLL might reverse the AKT/mTOR feedback activation induced by LDM at the first time. The results from both in vitro and in vivo experiments suggested that DTLL enhanced DNA damage via EGFR/HER2‐dependent blockage of PI3K/AKT/mTOR and PD‐L1 signaling pathways in cancer cells, leading to the inhibition of cell proliferation and immunosurveillance escape from pancreatic tumor. Our studies on DTLL functional characterization revealed its novel mechanisms on internal enhancement of DNA damage and implied that DTLL might provide a promising targeted therapeutic strategy for pancreatic cancer.
The emergence of accelerated resolution therapy for treatment of post‐traumatic stress disorder: A review and new subgroup analyses
Authors: Kip Kevin E. , Berumen Jessica , Zeidan Amina R. , Hernandez Diego F. , Finnegan Alan P. 
Published: January 2019

AbstractIntroductionPost‐traumatic stress disorder (PTSD) is a chronic, disabling psychiatric disorder prevalent among civilian and military personnel in the United States (US) and United Kingdom (UK). Current trauma‐focused psychotherapies may place high emotional demands and lengthy treatment commitment that may hinder successful treatment completion for some patients. Accelerated resolution therapy (ART) is an emerging trauma‐focused psychotherapy that is briefer than most current treatments.Materials and MethodsThis review describes the ART clinical protocol and theoretical underpinnings, its relationship to current treatments and formal established treatment guidelines and empirical research data. Also presented are new subgroup data for the use of ART among clients with PTSD and concomitant traumatic brain injury (TBI), and among US Special Operations Forces (SOF) personnel with extensive combat‐related trauma exposure. Treatment response was defined as ≥10‐point reduction on the 17‐item PCL‐M (PTSD Checklist).ResultsIn subgroup analyses, mean treatment with ART consisted of approximately four sessions. Among 202 US service members/veterans, intention‐to‐treat response rates (assuming no response for non‐completers) by TBI status were as follows: no TBI (58.1%, n = 105), mild TBI (60.4%, n = 48), moderate/severe TBI (46.9%, n = 49). Among 141 US service members/veterans, intention‐to‐treat response rates by SOF status were as follows: non‐SOF (54.3%, n = 116), SOF (60.0%, n = 25).ConclusionThe ART protocol aligns closely with established first‐line trauma‐focused psychotherapies and clinical guidelines. It appears to provide frequent clinical relief of symptoms of PTSD in an average of four sessions among military personnel with challenging clinical presentations, including concomitant TBI and extensive operational combat‐related trauma.
Chronic kidney disease is associated with increased mortality and procedural complications in transcatheter aortic valve replacement: a systematic review and meta‐analysis
Authors: Rattanawong Pattara , Kanitsoraphan Chanavuth , Kewcharoen Jakrin , Riangwiwat Tanawan , Chongyangyuenvong Pitchaporn , Vutthikraivit Wasawat , Mannem Santhosh R. , Chung Eugene H. 
Published: January 2019

AbstractObjectiveWe performed a systematic review and meta‐analysis to explore the association between chronic kidney disease (CKD) and mortality and procedural complications in transcatheter aortic valve replacement (TAVR).BackgroundThe impact of varying stages of CKD or end‐stage renal disease (ESRD) on patients receiving TAVR is not clearly identified.MethodsWe searched the databases of MEDLINE and EMBASE from inception to May 2018. Included studies were published TAVR studies that compared the risk of mortality and procedural complications in CKD patients compared to control patients. Data from each study were combined using the random‐effects model.ResultsTwelve studies (42,703 CKD patients and 51,347 controls) were included. Compared with controls, CKD patients had a significantly higher risk of 30‐day overall mortality (risk ratio [RR] = 1.56, 95% confidence interval [CI]: 1.34–1.80, I2 = 60.9), long‐term cardiovascular mortality (RR = 1.44, 95% CI: 1.22–1.70, I2 = 36.2%), and long‐term overall mortality (RR = 1.66, 95% CI: 1.45–1.91, I2 = 80.3), as well as procedural complications including pacemaker requirement (RR = 1.20, 95% CI: 1.03–1.39, I2 = 56.1%) and bleeding (RR = 1.60, 95% CI: 1.26–2.02, I2 = 86.0%). Risk of mortality and procedural complications increased with severity of CKD for stages 3, 4, and 5, respectively, in terms of long‐term overall mortality (RR = 1.28, 1.82, and 2.12), 30‐day overall mortality (RR = 1.26, 1.89, and 1.93), 30‐day cardiovascular mortality (RR = 1.18, 1.75, and 2.50), and 30‐day overall bleeding (RR = 1.19, 1.63, and 2.12).ConclusionsOur meta‐analysis demonstrates a significant increased risk of mortality and procedural complications in patients with CKD who underwent TAVR compared to controls.
Wire‐frame integrity of patch‐like Gore devices following atrial septal defect closure
Authors: Kubicki R. , Fingerhut K. , Uhl M. , Hummel J. , Höhn R. , Reineker K. , Fleck T. , Stiller B. , Grohmann J. 
Published: January 2019

AbstractObjectivesTo assess the structural integrity of the patch‐like Gore Septal Occluder (GSO) used for device closure of secundum‐type atrial septal defects (ASD II) in pediatric patients.BackgroundGSO has shown to be effective and safe for ASD device closure in children and adolescents.MethodsSingle‐center, retrospective mid‐ to long‐term follow‐up of all children and adolescents with a GSO in situ (≥12 months). Periprocedural data and follow‐up data were evaluated, including chest X‐rays to assess the GSO's wire‐frame morphology.ResultsNinety‐one consecutive patients were enrolled with a median age and weight of 5 years (range 2–18) and 20 kg (range 11–95) at implantation. ASD anatomy included 64 single and 27 multi‐fenestrated defects, with 39 patients having small retro‐aortic rims (≤4 mm). Median follow‐up period was 42.5 months (range 12–74). Chest X‐rays were available in 80 children: in 74 of them, the GSO's visualization on X‐ray enabled us to reliably assess the wire‐frame structure. Wire‐frame fracture (WFF) was ultimately detected in five of the 74 patients (6.8%); however, those occluders appeared stably anchored and well aligned to both sides of the septum, and no free wire fragments had escaped the GSO matrix. Thus, no further treatment was required.ConclusionsOur data confirm that the GSO is safe and effective for ASD closure. Despite its lightweight construction, the GSO seems to offer reliable mechanical durability. Wire‐frame fractures occur, but the free wire‐ends appear to have remained stable within the GSO matrix without any clinical sequelae so far.
1‐Arylvinyl formats: A New CO Source and Ketone Source in Carbonylative Synthesis of Chalcone Derivatives
Authors: Qi Xinxin , Lai Ming , Zhu Min‐Jie , Peng Jin‐Bao , Ying Jun , Wu Xiao‐Feng 
Published: January 2019

Abstract1‐Arylvinyl formates as a kind of new CO surrogate have been explored for the first time. Most of the known CO precursors usually produce undesired residuals, which have to be removed. In this strategy, after CO release, the in situ generated acetophenones from 1‐arylvinyl formates can be successfully applied as a good ketone source in the synthesis of chalcones with benzaldehydes via a palladium‐catalyzed reductive carbonylation reaction. A variety of chalcones were isolated in satisfactory to good yields with good substrates compatibilities under mild conditions.
Convenient One‐Pot Synthesis of 1,2,3,4‐Thiatriazoles Towards a Novel Electron Acceptor for Highly‐Efficient Thermally‐Activated Delayed‐Fluorescence Emitters
Authors: Qu Yangyang , Pander Piotr , Bucinskas Audrius , Vasylieva Marharyta , Tian Yayang , Miomandre Fabien , Dias Fernando B. , Clavier Gilles , Data Przemyslaw , Audebert Pierre 
Published: January 2019

AbstractA novel and unexpected convenient one‐pot synthesis of 1,2,3,4‐thiatriazoles has been discovered while investigating the classical tetrazine “Pinner synthesis”. The synthetic route starts from commercially‐available nitrile derivatives and gives good to high yields (51–80 %) with no need to isolate any thioacylating agents. The crucial impact of the solvent on the outcome of the modified “Pinner synthesis” is moreover examined and discussed. Using this new synthetic route, a novel donor‐acceptor thiatriazole derivative has been prepared, which exhibits prominent thermally‐activated delayed fluorescence (TADF) in both solution and film. The photoluminescence quantum yield (PLQY) in methylcyclohexane (MCH) and Zeonex (a cyclo olefin polymer) in oxygen‐free conditions were determined to be 76 and 99 %, respectively. This work provides an efficient and practical synthetic approach to functionalized 1,2,3,4‐thiatriazole derivatives, and will noticeably facilitate the application of 1,2,3,4‐thiatriazole as an electron acceptor in organic electronics.
Cyclooctatetraene: A Bioactive Cubane Paradigm Complement
Authors: Xing Hui , Houston Sevan D. , Chen Xuejie , Ghassabian Sussan , Fahrenhorst‐Jones Tyler , Kuo Andy , Murray Cody‐Ellen P. , Conn Kyna‐Anne , Jaeschke Kara N. , Jin Da‐Yun , Pasay Cielo , Bernhardt Paul V. , Burns Jed M. , Tsanaktsidis John , Savage G. Paul , Boyle Glen M. , De Voss James J. , McCarthy James , Walter Gimme H. , Burne Thomas H. J. , Smith Maree T. , Tie Jian‐Ke , Williams Craig M. 
Published: January 2019

AbstractCubane was recently validated as a phenyl ring (bio)isostere, but highly strained caged carbocyclic systems lack π character, which is often critical for mediating key biological interactions. This electronic property restriction associated with cubane has been addressed herein with cyclooctatetraene (COT), using known pharmaceutical and agrochemical compounds as templates. COT either outperformed or matched cubane in multiple cases suggesting that versatile complementarity exists between the two systems for enhanced bioactive molecule discovery.
Dehydratisierung von Butanol in nah‐ und überkritischem Wasser
Authors: Busch Heiner , Vogel Herbert 
Published: January 2019

AbstractEine alternative Zugangsmöglichkeit für chemische Zwischenprodukte stellt die Umsetzung von durch Fermentation gewonnenem Butanol zu Buten dar. Die speziellen Eigenschaften von Wasser nahe des kritischen Punktes ermöglichen eine direkte Dehydratisierung des Butanols ohne vorherige Abtrennung des Wassers. In dieser Arbeit wurde die Umsetzung von 1‐Butanol aus wässriger Lösung zu Buten untersucht. In einem CSTR‐Reaktor wurden der Einfluss von verschiedenen Elektrolyten, Temperatur und Verweilzeit auf den Umsatz und die Produktverteilung quantifiziert. Zum besseren Verständnis der Reaktion wurden zudem Versuche zum Reaktionsverhalten von 2‐Butanol sowie zur Bestimmung der Dichte und des Phasenverhaltens durchgeführt.
Dynamic modelling and simulation of the sulphur dioxide converter in an industrial smelter
Authors: He Jianjun , Zhang Junfeng , Shang Helen 
Published: January 2019

AbstractSulphuric acid plants have been widely used in industrial smelters to reduce sulphur dioxide () emissions to the atmosphere. The catalytic converter, where is oxidized to sulphur trioxide (), is the key unit and determines the performance of a sulphuric acid plant. In this paper, a dynamic model is built based on mass and energy conservation for the converter in an industrial smelter. The derived model is compared with industrial measurement and a very good fit is obtained. A key variable of high industrial interest, conversion ratio, is defined and explored in modelling the converter, and thus the resulting model is of important industrial values. Based on the derived model, simulations are run to investigate the system dynamics and effects of process variables.