bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lake‐type controls on sedimentary infill and petroleum source rocks in the Palaeogene Fushan Depression, Beibuwan Basin, South China
Authors: Jin Siding , Wang Hua , Cao Haiyang , Gan Huajun , Chen Shanbin 
Published: September 2019

The lacustrine Beibuwan Basin contained large petroleum reserves in the northern continental shelf of the South China Sea. Due to the great sedimentologic complexity of the lacustrine basins, a significant financial risk associated with exploration needed to be reduced by specific techniques or significantly increasing knowledge of the lake system. Sedimentary infill, sequence stratigraphy, and organic geochemistry of the Fushan Depression in the Beibuwan Basin were studied, and enhanced our comprehension of the genetic relations between the sediment + water supply rates (climate change) and potential accommodation (tectonic subsidence and inherited topography) change. Here, we report two different lake‐type evolution cycles developed in two separated sags in the Fushan Depression, which are characterized by: (a) overfilled, (b) balanced‐fill, (c) overfilled, (d) balanced‐fill, and (e) overfilled in the Huangtong Sag, and (a) overfilled, (b) balanced‐fill, and (c) overfilled in the Bailian Sag and the centre Huachang Transfer Zone. Climate change is the dominant factor in the first three phases of the lake‐type evolution in both two sags, and transtensional tectonic setting is the controlling factor in the fourth and fifth phases of the lake‐type evolution in the Huangtong Sag. The same lake‐type with similar source rock and reservoir properties and observations indicate that these associations of source rock and reservoir play elements occur in a wide variety of tectonic settings. Moreover, the discovery of the cyclical process of the lake‐type evolution in the Fushan Depression can be a reference in the study of other similar lacustrine basins under an analogous tectonic and climate background.
Tactics of speaking up: The roles of issue importance, perceived managerial openness, and managers' positive mood
Authors: Xu Erica , Huang Xu , Ouyang Kan , Liu Wu , Hu Saiquan 
Published: September 2019

AbstractExtant voice research has focused mainly on the conditions under which employees speak up, but we have limited knowledge about how employees speak up. This study examines voice tactics or the various ways in which employees express concerns to or share suggestions with their managers. Based on the notion that voice is a deliberative behavior, we draw upon a cost–benefit framework and propose that voice tactics are influenced by messages' characteristics and managers' stable and temporal characteristics. Specifically, we examine the joint effects of issue importance, perceived managerial openness, and managers' positive mood on employees' public (vs. private) and formal (vs. informal) voice tactics. Across two independent studies, our findings demonstrate that employees tend to use public channels and formal procedures only when three conditions are met simultaneously: (a) the issue is important, (b) managers are perceived as being open to employees' voice, and (c) managers are in a positive mood at the time of voicing. In addition, we found that speaking up via public channels or formal procedures is positively related to the success of voice.
Importance of rainfall partitioning in a northern mixed forest canopy for soil water isotopic signatures in ecohydrological studies
Authors: Snelgrove Jenna R. , Buttle J.M. , Tetzlaff D. 
Published: September 2019

AbstractThe forest canopy can play a significant role in modifying the amount and isotopic composition of water during its passage throughout the near‐surface critical zone. Here, partitioning of gross rainfall into interception, throughfall, and stemflow and its implications for the amount and isotopic composition of soil water was studied for red oak, eastern white pine, and eastern hemlock trees in a northern hardwood‐conifer forest in south central Ontario, Canada. Stemflow production was greatest for red oak as a result of its upward‐projecting branches and least for eastern white pine due to its horizontal branches and rougher bark. These stemflow contributions to the near‐bole soil surface failed to produce consistently wetter soils relative to distal locations from the bole for all tree species. There was also no consistent evidence of isotopic enrichment of throughfall and stemflow relative to gross rainfall or of stemflow relative to throughfall for red oak or eastern hemlock. However, there was isotopic enrichment of both throughfall and stemflow for eastern white pine with increasing maximum atmospheric vapour pressure deficit, which may reflect the potential for evaporative fractionation as a result of retention and detention of water moving through the canopy by the rougher bark of this species. Dry soil conditions limited sampling of mobile soil water during the study, and there was no consistent evidence that either throughfall or stemflow fluxes controlled temporal changes in the isotopic signature of soil water beneath the tree. Thus, the potential for throughfall and stemflow fluxes in northern hardwood‐conifer forests to modify the isotopic composition of water taken up by the tree via transpiration remains an open question.
Pathological crystal imaging with single‐shot computational polarized light microscopy
Authors: Bai Bijie , Wang Hongda , Liu Tairan , Rivenson Yair , FitzGerald John , Ozcan Aydogan 
Published: September 2019

AbstractPathological crystal identification is routinely practiced in rheumatology for diagnosing arthritis disease such as gout, and relies on polarized light microscopy as the gold standard method used by medical professionals. Here, we present a single‐shot computational polarized light microscopy method that reconstructs the transmittance, retardance and slow‐axis orientation of a birefringent sample using a single image captured with a pixelated‐polarizer camera. This method is fast, simple‐to‐operate and compatible with all the existing standard microscopes without extensive or costly modifications. We demonstrated the success of our method by imaging three different types of crystals found in synovial fluid and reconstructed the birefringence information of these samples using a single image, without being affected by the orientation of individual crystals within the sample field‐of‐view. We believe this technique will provide improved sensitivity, specificity and speed, all at low cost, for clinical diagnosis of crystals found in synovial fluid and other bodily fluids.
Safety of wireless capsule endoscopy in patients with implantable cardiac devices
Authors: Kasia Christopher , Appannagari Anoop , Joshi Anjali , Venu Mukund 
Published: September 2019

Background and AimWireless capsule endoscopy (WCE) has become an increasingly utilized imaging modality for the evaluation of gastrointestinal bleeding. There is a paucity of data evaluating the safety and use of WCE in patients with implantable cardiac devices.MethodsA retrospective chart review of all patients who had a WCE at Loyola University Medical Center in Maywood, IL, USA completed between January 2007 and December 2016 identified patients with internal cardiac devices and obscure gastrointestinal bleeding. Patient WCE footage was viewed in its entirety before creating a final report to ensure no gaps in footage and video quality.ResultsNo patient complaints were documented during the 8‐h procedure duration, and there were no cardiac abnormalities noted on telemetry. There were no device‐related complications documented in the 30‐day postprocedure time period. Postprocedure analysis of the WCE recordings demonstrated no interference in WCE image quality (loss of images or gaps in video) or duration.ConclusionsThere is no significant interference between WCE and implantable cardiac devices, and it appears to be safe to use.
Synthesis and antitumor evaluation of some new derivatives and fused heterocyclic compounds derived from thieno[2,3‐b]pyridine
Authors: Hassan Aisha Y. , Sarg Marwa T. , El‐Sebaey Samiha A. 
Published: September 2019

On the basis of the proven activity of thieno[2,3‐b]pyridines as anticancer, we have designed to synthesize a novel several heterocyclic compounds utilizing thieno[2,3‐b]pyridine as a skeleton through various chemical reactions. The synthesized compounds bear rings that are either directly attached to the thieno[2,3‐b]pyridine as in compounds 4 to 6 and 9 or connected through an amide bridge as compounds 2, 3a‐b, 7, and 8. As well as, compounds 10, 12 to 28, 30, 31, and 33 to 36 bear fused rings to the thieno[2,3‐b]pyridine backbone. The newly synthesized compounds were screened for their antiproliferative activity in vitro against hepatocellular carcinoma (HepG‐2) and breast cancer (MCF‐7) compared with the standard drug (doxorubicin). Compounds 3b, 4, 6, 22, and 28 exhibited promising growth inhibitory effect toward both HepG‐2 and MCF‐7 cell lines with IC50 values ranging from 5.88 to 11.70 μg/mL and 9.64 to 15.10 μg/mL, respectively.
Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming
Authors: Sureshchandra Suhas , Marshall Nicole E , Messaoudi Ilhem 
Published: September 2019

Abstract
Maternal pregravid obesity results in several adverse health outcomes during pregnancy, including increased risk of gestational diabetes, preeclampsia, placental abruption, and complications at delivery. Additionally, pregravid obesity and in utero exposure to high fat diet have been shown to have detrimental effects on fetal programming, predisposing the offspring to adverse cardiometabolic, endocrine, and neurodevelopmental outcomes. More recently, a deeper appreciation for the modulation of offspring immunity and infectious disease-related outcomes by maternal pregravid obesity has emerged. This review will describe currently available animal models for studying the impact of maternal pregravid obesity on fetal immunity and review the data from clinical and animal model studies. We also examine the burden of pregravid obesity on the maternal–fetal interface and the link between placental and systemic inflammation. Finally, we discuss future studies needed to identify key mechanistic underpinnings that link maternal inflammatory changes and fetal cellular reprogramming events.
Association between periodontal status and non‐alcoholic fatty liver disease in a Korean adult population: A nationwide cross‐sectional study
Authors: Shin Hye‐Sun 
Published: September 2019

AbstractBackgroundThe objective of this study was to investigate the association between periodontal status and non‐alcoholic fatty liver disease (NAFLD) indicators in a representative Korean population.MethodsA cross‐sectional study was conducted on 4061 participants >19 years of age using the 2010 Korea National Health and Nutrition Examination Survey data. Periodontal status was assessed by trained dentists using the community periodontal index. To identify the presence of NAFLD, biochemical data were defined using two validated indicators: the fatty liver index (FLI) and the hepatic steatosis index (HSI). The associations of the presence of periodontal pockets with FLI and HSI were evaluated by multivariable logistic regression analysis after adjusting for age, income, education level, smoking status, alcohol consumption, physical activity, diabetes mellitus, obesity, hypertension, and hypercholesterolemia.ResultsThe adjusted means in the FLI indicator increased in the presence of periodontal pockets, whereas there was no significant difference in the HSI (P = 0.005 for FLI; P = 0.142 for HSI). Periodontal pockets were consistently associated with the two NAFLD indicators in the sequential logistic models for women throughout the adjustment process. (OR = 1.77, 95% CI = 1.05 to 2.98 for FLI, OR = 1.64, 95% CI = 1.08 to 2.51 for HSI).ConclusionsOur findings showed that the presence of periodontal pockets may be independently associated with NAFLD indicators. Further study will be clarified by well‐designed longitudinal studies.
MiR‐22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF‐κB pathway
Authors: Yang Qing‐Yi , Yang Kai‐Peng , Li Zhi‐Zhou 
Published: September 2019

AbstractIt has demonstrated that miR‐22 overexpression can suppress the inflammation process of rheumatoid arthritis (RA) in synoviocytes. But, the underlying mechanism of miR‐22 expression in regulating RA is still not well illustrated. In this study, we investigated the functional role and underlying mechanism of miR‐22 in regulating RA. Human RA fibroblast‐like synoviocyte (FLS) cell line MH7A cells was transfected by miR‐22 mimic and its control. CCK8 was utilized to detect cell proliferation. Cell apoptosis was analyzed by flow cytometry. MH7A cells stimulating with interleukin‐1β (IL‐1β) were transfected with miR‐22 mimic. Quantitative real time polymerase chain reaction (qRT‐PCR) and western blot assays were utilized to detect mRNA and protein expression. miR‐22 targets were predicted and validated by Targetscan and luciferase reporter assay. We revealed that miR‐22 showed downregulated expression in MH7A after stimulation with IL‐1β. Additionally, miR‐22 overexpression suppressed the proliferation and facilitated apoptosis in MH7A cells. IL6R was a target of miR‐22. Besides, miR‐22 overexpression inhibited the expression of IL6R and also suppressed inflammatory pathway NF‐κB. These results indicated that miR‐22 overexpression could restrain the activity of inflammation cells in RA by targeting IL6R and might be concerned with the inhibition of NF‐κB pathway.
Power loss characteristics analysis of slipper pair in axial piston pump considering thermoelastohydrodynamic deformation
Authors: Hesheng Tang , Yan Ren , Jiawei Xiang 
Published: September 2019

AbstractThe power loss characteristics of slipper pair in an axial piston pump considering the thermoelastohydrodynamic deformation are investigated based on a transient power loss model. The simulation results indicate that the leakage power loss of the slipper pair increases with increasing the thermoelastohydrodynamic deformation. The viscous friction power loss decreases with an increase in the thermoelastohydrodynamic pressure. The viscous friction becomes sufficiently large under the influence of slipper surface roughness that it leads to an increase in viscous friction power loss. The pump displacement decreases with increasing the leakage rate and results in higher leakage power loss and higher friction power loss. To achieve minimum power loss in the slipper, an objective optimization study using Newton's method is applied to calculate structural parameters such as slipper inner diameter, slipper outer diameter, and orifice diameter. The proposed structural parameter optimization can be used as theoretical evidence for slipper pair design.
Soluble Telechelic Polycondensation Poly(ether ketones): Synthesis and Characterization
Authors: Benhalima Abdelkader , Furtos Alexandra , Brisson Josée 
Published: September 2019

AbstractThe present article reports the synthesis of soluble, propyl‐substituted aromatic ring telechelic polycondensation blocks having molecular weights ranging from 1800 to 6500 g mol−1and polymolecularities of 1.3 to 1.7. Chain‐growth polycondensation is performed, and the initiator is selected through reactivity studies, using19F nuclear magnetic resonance (NMR) measurements. Gel permeation chromatography, NMR spectroscopy, and matrix‐assisted laser desorption/ionization time of flight mass spectrometry show that blocks are terminated by a methoxy group at one end and a fluorine atom at the other. Polymers are crystalline as synthesized, as shown by X‐ray diffraction and differential scanning calorimetry, do not recrystallize once melted, and undergo solvent‐induced crystallization. Crystalline peak positions and relative intensities are different from those observed for other poly(ether ketones). The difference in crystal form is proposed to stem from packing disruption related to the presence of propyl substituents. Thermogravimetry shows a good thermal resistance up to 450 °C.
Strain‐Sensitive Performance of a Tough and Ink‐Writable Polyacrylic Acid Ionic Gel Crosslinked by Carboxymethyl Cellulose
Authors: Jin Shuping , Qiu Jianhui , Sun Manxi , Huang Hongjian , Sakai Eiichi 
Published: September 2019

AbstractA tough polyacrylic acid ionic gel is obtained using carboxymethyl cellulose as a crosslinker and KCl as a conductive ions donor. The polymerization process is initiated by ceric ammonium nitrate and triggered by visible light, which can be employed as a facile 3D printing process to fabricate arbitrary gel architectures. Curling macromolecular crosslinker and plentiful hydrogen bonds among polymers endow the ionic gel with superior mechanical performance including high tensile strength (≈1.33 MPa), large elongation (>8 times), high toughness (≈5.11 MJ m−3), and good self‐recovery property. Importantly, the ionic gel can be assembled into a flexible strain sensor to precisely monitor the diverse human body motions in real time, that is, joints bending and muscle contraction, by recording the capacitance variation. This strain‐sensitive performance, which can recover even after 1000 successive cycles, should enable the detection of body action and provide a potential application in health‐care monitoring or human–computer user interfaces.
Intronic (TTTGA)n insertion in SAMD12 also causes familial cortical myoclonic tremor with epilepsy
Authors: Cen Zhidong , Chen You , Yang Dehao , Zhu Qingchen , Chen Si , Chen Xinhui , Wang Bo , Xie Fei , Ouyang Zhiyuan , Jiang Zhengwen , Fu Aisi , Hu Ben , Yin Houmin , Qiu Xia , Yu Feng , Du Xiaoping , Hao Weicheng , Liu Yuxi , Wang Haotian , Wang Lebo , Yu Xiafei , Xiao Yichuan , Liu Chunyu , Xiao Jianfeng , Zhou Yongxing , Yang Wei , Zhang Baorong , Luo Wei 
Published: September 2019

AbstractBackgroundIntronic (TTTCA)n insertions in the SAMD12, TNRC6A, and RAPGEF2 genes have been identified as causes of familial cortical myoclonic tremor with epilepsy.ObjectiveTo identify the cause of familial cortical myoclonic tremor with epilepsy pedigrees without (TTTCA)n insertions in SAMD12, TNRC6A, and RAPGEF2.MethodsRepeat‐primed polymerase chain reaction, long‐range polymerase chain reaction, and Sanger sequencing were performed to identify the existence of a novel (TTTGA)n insertion. Targeted long‐read sequencing was performed to confirm the accurate structure of the (TTTGA)n insertion.ResultsWe identified a novel expanded intronic (TTTGA)n insertion at the same site as the previously reported (TTTCA)n insertion in SAMD12. This insertion cosegregated with familial cortical myoclonic tremor with epilepsy in 1 Chinese pedigree with no (TTTCA)n insertion. In the targeted long‐read sequencing of 2 patients and 1 asymptomatic carrier in this pedigree, with 1 previously reported (TTTCA)n‐insertion–carrying patient as a positive control, a respective total of 302, 159, 207, and 50 on‐target subreads (predicated accuracy: ≥90%) spanning the target repeat expansion region were generated. These sequencing data revealed the accurate repeat expansion structures as (TTTTA)114‐123(TTTGA)108‐116 in the pedigree and (TTTTA)38(TTTCA)479 in (TTTCA)n‐insertion–carrying patient.ConclusionThe targeted long‐read sequencing helped us to elucidate the accurate structures of the (TTTGA)n and (TTTCA)n insertions. Our finding offers a novel possible cause for familial cortical myoclonic tremor with epilepsy and might shed light on the identification of genetic causes of this disease in pedigrees with no detected (TTTCA)n insertion in the reported causative genes. © 2019 International Parkinson and Movement Disorder Society
The uptake of family screening in hypertrophic cardiomyopathy and an online video intervention to facilitate family communication
Authors: Harris Stephanie , Cirino Allison L. , Carr Christina W. , Tafessu Hiwot M. , Parmar Siddharth , Greenberg Jeffrey O. , Szent‐Gyorgyi Lara E. , Ghazinouri Roya , Glowny Michelle G. , McNeil Kara , Kaynor Efthalia F. , Neumann Catherine , Seidman Christine E. , MacRae Calum A. , Ho Carolyn Y. , Lakdawala Neal K. 
Published: September 2019

AbstractBackgroundIndividuals with hypertrophic cardiomyopathy (HCM), even when asymptomatic, are at‐risk for sudden cardiac death and stroke from arrhythmias, making it imperative to identify individuals affected by this familial disorder. Consensus guidelines recommend that first‐degree relatives (FDRs) of a person with HCM undergo serial cardiovascular evaluations.MethodsWe determined the uptake of family screening in patients with HCM and developed an online video intervention to facilitate family communication and screening. Family screening and genetic testing data were collected through a prospective quality improvement initiative, a standardized clinical assessment and management plan (SCAMP), utilized in an established cardiovascular genetics clinic. Patients were prescribed an online video if screening of their FDRs was incomplete and a pilot study on video utilization and family communication was conducted.ResultsTwo‐hundred and sixteen probands with HCM were enrolled in SCAMP Phase I and 190 were enrolled in SCAMP Phase II. In both phases, probands reported that 51% of FDRs had been screened (382/749 in Phase I, 258/504 in Phase II). Twenty patients participated in a pilot study on video utilization and family communication. Nine participants reported watching the video and six participants reported sharing the video with relatives; however only one participant reported sharing the video with relatives who were not yet aware of the diagnosis of HCM in the family.ConclusionDespite care in a specialized cardiovascular genetics clinic, approximately one half of FDRs of patients with HCM remained unscreened. Online interventions and videos may serve as supplemental tools for patients communicating genetic risk information to relatives.
Whole‐exome sequencing provides insights into monogenic disease prevalence in Northwest Russia
Authors: Barbitoff Yury A. , Skitchenko Rostislav K. , Poleshchuk Olga I. , Shikov Anton E. , Serebryakova Elena A. , Nasykhova Yulia A. , Polev Dmitrii E. , Shuvalova Anna R. , Shcherbakova Irina V. , Fedyakov Mikhail A. , Glotov Oleg S. , Glotov Andrey S. , Predeus Alexander V. 
Published: September 2019

AbstractBackgroundAllele frequency data from large exome and genome aggregation projects such as the Genome Aggregation Database (gnomAD) are of ultimate importance to the interpretation of medical resequencing data. However, allele frequencies might significantly differ in poorly studied populations that are underrepresented in large‐scale projects, such as the Russian population.MethodsIn this work, we leveraged our access to a large dataset of 694 exome samples to analyze genetic variation in the Northwest Russia. We compared the spectrum of genetic variants to the dbSNP build 151, and made estimates of ClinVar‐based autosomal recessive (AR) disease allele prevalence as compared to gnomAD r. 2.1.ResultsAn estimated 9.3% of discovered variants were not present in dbSNP. We report statistically significant overrepresentation of pathogenic variants for several Mendelian disorders, including phenylketonuria (PAH, rs5030858), Wilson's disease (ATP7B, rs76151636), factor VII deficiency (F7, rs36209567), kyphoscoliosis type of Ehlers‐Danlos syndrome (FKBP14, rs542489955), and several other recessive pathologies. We also make primary estimates of monogenic disease incidence in the population, with retinal dystrophy, cystic fibrosis, and phenylketonuria being the most frequent AR pathologies.ConclusionOur observations demonstrate the utility of population‐specific allele frequency data to the diagnosis of monogenic disorders using high‐throughput technologies.