bluuebunny/crossref_metadata_2025_split huggingface dataset:
Honeycomb‐Inspired Heterogeneous Bimetallic Co–Mo Oxide Nanoarchitectures for High‐Rate Electrochemical Lithium Storage
Authors: Mei Jun , Liao Ting , Spratt Henry , Ayoko Godwin A. , Zhao X. S. , Sun Ziqi 
Published: March 2019

AbstractNanostructure engineering has been proved to be an efficient approach for improving electrochemical properties for energy storage by accommodating volume changes, facilitating rapid mass transport paths, and enlarging ion storage sites and interfaces. The well‐designed fine nanostructures, unfortunately, are usually destroyed during long‐term cycles and ultimately lose their structural advantages. Herein, stimulated by the extraordinary structural stability, robust mechanical properties, and salient ventilation capacity of natural honeycomb species, bioinspired heterogeneous bimetallic Co–Mo oxide (CoMoOx) nanoarchitectures assembled from 2D nanounits are successfully fabricated via a molybdenum‐mediated self‐assembly strategy for improving the rate capability of electrochemical lithium storage devices. Owing to the robust structural stability and the ultrathin 2D wall structure, CoMoOx nanostructures present well‐maintained honeycomb‐like structure, rapid capacitive insertion–desertion behaviors, and thus significantly enhanced lithium ion storage performance at high rates (5.0 A g−1). It is also revealed that the reversible transition of cobalt and molybdenum phases closely associated with the ultrathin 2D wall structures greatly contribute to the outstanding electrochemical lithium storage performances. This attractive integration of structural and functional advantages achieved by learning from nature offers new insights into the design of cost‐effective electrode materials for high‐performance energy devices.
Enhanced n-body annihilation of dark matter and its indirect signatures
Authors: Namjoo Mohammad Hossein , Slatyer Tracy R. , Wu Chih-Liang 
Published: March 2019

AbstractWe examine the possible indirect signatures of dark matter annihilation processes with a non-standard scaling with the dark matter density, and in particular the case where more than two dark matter particles participate in the annihilation process. We point out that such processes can be strongly enhanced at low velocities without violating unitarity, similar to Sommerfeld enhancement in the standard case of two-body annihilation, potentially leading to visible signals in indirect searches. We study in detail the impact of such multi-body annihilations on the ionization history of the universe and consequently the cosmic microwave background, and find that unlike in the two-body case, the dominant signal can naturally arise from the end of the cosmic dark ages, after the onset of structure formation. We examine the complementary constraints from the Galactic Center, Galactic halo, and galaxy clusters, and outline the circumstances under which each search would give rise to the strongest constraints. We also show that if there is a population of ultra-compact dense dark matter clumps present in the Milky Way with sufficiently steep density profile, then it might be possible to detect point sources illuminated by multi-body annihilation, even if there is no large low-velocity enhancement. Finally, we provide a case study of a model where 3-body annihilation dominates the freezeout process, and in particular the resonant regime where a large low-velocity enhancement is naturally generated.
Youth and young adult dating relationship dynamics and subsequent abusive outcomes
Authors: Mumford Elizabeth A. , Liu Weiwei , Taylor Bruce G. 
Published: March 2019

AbstractIntroductionIn order to prevent youth and young adult partner abuse, it is necessary to have a better understanding of dating relationship dynamics as the context for potential abusive interactions.MethodsYouth and young adults (ages 10–18 at baseline) were surveyed along with a matched parent/caregiver. Data, including parent and youth responses (n = 437 youth/parent dyads), are drawn from the nationally representative Survey on Teen Relationships and Intimate Violence (STRiV).ResultsApplying latent class analytic techniques with seven different positive and problematic descriptors of dating relationships, this study found four classes of relationship dynamics representing healthy, unhealthy, intense, and disengaged relationships. The intense relationship dynamic class exhibits the strongest associations with reports of any youth and young adult partner abuse, as well as distinctly with the subtypes of psychological, physical, and sexual victimization and perpetration.ConclusionsResults demonstrate the importance of clinicians, parents and other responsible adults attending to an array of youth and young adult dating relationship dynamics rather than single indicators, to assess youth and young adult risk for involvement in abusive relationships.
Advances in reducing cardiovascular risk in the management of patients with type 2 diabetes mellitus
Authors: Hu Ying 
Published: March 2019

AbstractTreatment intended to lower cardiovascular (CV) risk in patients with diabetes has always been a primary goal of diabetes treatment. Due to the subdued effects of reducing hemoglobin A1c (HbA1c) on macrovascular complications, controlling other CV risk factors such as hypertension and hyperlipidemia instead of hyperglycemia has been the mainstay treatment to improve CV outcome in patients with type 2 diabetes mellitus (T2DM) until recent years. This review is intended to summarize and compare the results from the available cardiovascular outcome trials (CVOTs) for the two classes of glucose lowering drug: sodium‐glucose co‐transporter 2 inhibitor (SGLT2i) and glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA). The results including the EMPA‐REG, CANVAS program and DECLARE‐TIMI 58 trials for SGLT2i, and the ELIXA, LEADER, SUSTAIN‐6, EXSCEL and HARMONY trials for GLP‐1 RA were summarized. The potential mechanisms of these CV beneficial effects and the optimal CV risk reduction treatment in patients with T2DM based on patient risk stratification and evidence from these CVOTs in real‐world setting were discussed.
Autonomous soaring using a simplified MPC approach
Authors: Pogorzelski G. , Silvestre F. J. 
Published: March 2019

ABSTRACTThe need for efficient propulsion systems allied to increasingly more challenging fixed-wing UAV mission requirements has led to recent research on the autonomous thermal soaring field with promising results. As part of that effort, the feasibility and advantages of model predictive control (MPC)-based guidance and control algorithms capable of extracting energy from natural occurring updrafts have already been demonstrated numerically. However, given the nature of the dominant atmospheric phenomena and the amplitude of the required manoeuvres, a non-linear optimal control problem results. Depending on the adopted prediction horizon length, it may be of large order, leading to implementation and real-time operation difficulties. Knowing that, an alternative MPC-based autonomous thermal soaring controller is presented herein. It is designed to yield a simple and small non-linear programming problem to be solved online. In order to accomplish that, linear prediction schemes are employed to impose the differential constraints, thus no extra variables are added to the problem and only linear bound restrictions result. For capturing the governing non-linear effects during the climb phase, a simplified representation of the aircraft kinematics with quasi-steady corrections is used by the controller internal model. Flight simulation results using a 3 degree-of-freedom model subjected to a randomly generated time varying thermal environment show that the aircraft is able to locate and exploit updrafts, suggesting that the proposed algorithm is a feasible MPC strategy to be employed in a practical application.
Influences of forested and grassland vegetation on late Quaternary ecosystem development as recorded in lacustrine sediments
Authors: McLauchlan Kendra K. , Lascu Ioan , Mellicant Emily , Scharping Robert J. , Williams Joseph J. 
Published: March 2019

AbstractGeosphere-biosphere interactions are ubiquitous features of the Earth surface, yet the development of interactions between newly exposed lithologic surfaces and colonizing plants during primary succession after glaciation are lacking temporal detail. To assess the nature, rate, and magnitude of vegetation influence on parent material and sediment delivery, we analyzed ecosystem and geochemical proxies from lacustrine sediment cores at a grassland site and a forested site in the northern United States. Over time, terrigenous inputs declined at both sites, with increasing amounts of organic inputs toward present. The similarities between sites were striking given that the grassland sequence began in the Early Holocene, and the forested sequence began after the last glacial maximum. Multiple mechanisms of chemical weathering, hydrologic transport, and changes in source material potentially contribute to this pattern. Although there were strong links between vegetation composition and nitrogen cycling at each site, it appears that changes in forest type, or from oak woodland to grassland, did not exert a large influence on elemental (K, Ti, Si, Ca, Fe, Mn, and S) abundance in the sedimentary sequences. Rather, other factors in the catchment-lake system determined the temporal sequence of elemental abundance.
Cost-Effectiveness of Pain Management Strategies in Advanced Cancer
Authors: Meads David M. , O'Dwyer John L. , Hulme Claire T. , Lopez Rocio Rodriguez , Bennett Michael I. 
Published: March 2019

AbstractObjectivesUncontrolled pain in advanced cancer is a common problem and has significant impact on individuals’ quality of life and use of healthcare resources. Interventions to help manage pain at the end of life are available, but there is limited economic evidence to support their wider implementation. We conducted a case study economic evaluation of two pain self-management interventions (PainCheck and Tackling Cancer Pain Toolkit [TCPT]) compared with usual care.MethodsWe generated a decision-analytic model to facilitate the evaluation. This modelled the survival of individuals at the end of life as they moved through pain severity categories. Intervention effectiveness was based on published meta-analyses results. The evaluation was conducted from the perspective of the U.K. health service provider and reported cost per quality-adjusted life-year (QALY).ResultsPainCheck and TCPT were cheaper (respective incremental costs -GBP148 [-EUR168.53] and -GBP474 [-EUR539.74]) and more effective (respective incremental QALYs of 0.010 and 0.013) than usual care. There was a 65 percent and 99.5 percent chance of cost-effectiveness for PainCheck and TCPT, respectively. Results were relatively robust to sensitivity analyses. The most important driver of cost-effectiveness was level of pain reduction (intervention effectiveness). Although cost savings were modest per patient, these were considerable when accounting for the number of potential intervention beneficiaries.ConclusionsEducational and monitoring/feedback interventions have the potential to be cost-effective. Economic evaluations based on estimates of effectiveness from published meta-analyses and using a decision modeling approach can support commissioning decisions and implementation of pain management strategies.
Music, the Realist Conception of Art and the Materialist Conception of History
Authors: HAMMEL STEPHAN 
Published: March 2019

AbstractOur fraught political moment is a propitious one for renewing the Marxist approach to music. Because that approach has consistently been folded into a more general Marxist discourse on art and aesthetics, any attempt must begin by revisiting what is essential to that discourse. I take its keystone to be the realist conception of art. This conception holds that artworks are a means by which at least some of their appreciators come to know truths about the world outside consciousness. Insofar as they are representational, painting, fiction, music, and drama potentially constitute vehicles for coming to understand the real world. Artistic representation on this view is understood to be analogous to mental representation.Previous studies of Marxist aesthetics have followed Maurice Merleau-Ponty in making a sharp distinction between ‘Eastern’ and ‘Western’ branches of the tradition. The Eastern, beleaguered by the exigencies of Communist Party rule is often presented as the corrupt twin of the Western. The latter, developed in relative freedom and informed by a Hegelian legacy suppressed by Stalinism, alone commands theoretical, rather than merely historical, interest. This article departs from this Cold War framework in arguing that the Hegelian strand in Marxist aesthetics grows out of its Bolshevik predecessor and, crucially, shares with it a realist conception of art. After reconstructing the emergence and development of this conception (paying special attention to how music is directly addressed in the literature), I evaluate the compatibility of the realist conception of art with the materialist conception of history as it is found in Marx and Engels. I ultimately argue that moving past the realist conception of art is key to renewing the Marxist approach to music for our time.
From a model of peace to a model of conflict: The effect of architectural modernization on the Syrian urban and social make-up
Authors: Al-Sabouni Marwa 
Published: March 2019

AbstractFrom a land called the “Cradle of Civilizations” to one that is now described as “apocalyptic” and “one of the most dangerous places on Earth”, Syria may have no more critical moment than the current crisis to reflect on what is taking it down this terrifyingly dark path. We resort to history in order to decipher the mysteries of the present, and there is no more honest and direct history than that of the built environment: a concrete object that tells the narratives not only of the winners, the wealthy and the powerful, but also of those who were brushed aside, cut apart and walked over.This Opinion Note argues that reversing the process which led to the loss of home and the loss of urban fabric is the foundation of reclaiming these as essential elements of recovery after war and destruction. It examines four areas of transformation where modern urban planning and architecture have left their marks on the Levantine city, to give a clearer understanding of the role of architecture and where to begin in the rebuilding.
Mitigation of Extreme Ocean Anoxic Event Conditions by Organic Matter Sulfurization
Authors: Hülse D. , Arndt S. , Ridgwell A. 
Published: March 2019

AbstractPast occurrences of widespread and severe anoxia in the ocean have frequently been associated with abundant geological evidence for free hydrogen sulfide (H2S) in the water column, so‐called euxinic conditions. Free H2S may react with, and modify, the chemical structure of organic matter settling through the water column and in marine sediments, with hypothesized implications for carbon sequestration. Here, taking the example of Ocean Anoxic Event 2, we explore the potential impact of organic matter sulfurization on marine carbon and oxygen cycling by means of Earth system modeling. Our model experiments demonstrate that rapid sulfurization (ksulf≥ = 105 M−1 year−1) of organic matter in the water column can drive a more than 30% enhancement of organic carbon preservation and burial in marine sediments and hence help accelerate climate cooling and Ocean Anoxic Event 2 recovery. As a consequence of organic matter sulfurization, we also find that H2S can be rapidly scavenged and the euxinic ocean volume reduced by up to 80%—helping reoxygenate the ocean as well as reducing toxic H2S emissions to the atmosphere, with potential implications for the kill mechanism at the end‐Permian. Finally, we find that the addition of organic matter sulfurization induces a series of additional feedbacks, including further atmospheric CO2 drawdown and ocean reoxygenation by the creation of a previously unrecognized net source of alkalinity to the ocean as H2S is scavenged and buried.
Endogenous dopamine release under transcranial direct-current stimulation governs enhanced attention: a study with positron emission tomography
Authors: Fukai Mina , Bunai Tomoyasu , Hirosawa Tetsu , Kikuchi Mitsuru , Ito Shigeru , Minabe Yoshio , Ouchi Yasuomi 
Published: March 2019

AbstractTranscranial direct-current stimulation (tDCS) to the dorsolateral prefrontal cortex (DLPFC) has been established as an effective and noninvasive method to modulate cognitive function. Nevertheless, the mechanisms causing those cognitive changes under the tDCS remain largely unknown. We strove to elucidate the cognito-biological relation under the tDCS condition by examining whether the dopamine system activated by tDCS is involved in cognitive changes in human participants, or not. To evaluate the dopamine system, we used [11C]-raclopride positron emission tomography (PET) scanning: 20 healthy men underwent two [11C]-raclopride PET scans and subsequent neuropsychological tests. One scan was conducted after tDCS to the DLPFC. One was conducted after sham stimulation (control). Results of [11C]-raclopride PET measurements demonstrate that tDCS to the DLPFC caused dopamine release in the right ventral striatum. Neuropsychological tests for attentiveness revealed that tDCS to the DLPFC-enhanced participants’ accuracy. Moreover, this effect was correlated significantly with dopamine release. This finding provides clinico-biological evidence, demonstrating that enhancement of dopamine signaling by tDCS in the ventral striatum is associated with attention enhancement.
ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury
Authors: Peng Xuan , Wang Yating , Li Huiyan , Fan Jinjin , Shen Jiani , Yu Xueqing , Zhou Yi , Mao Haiping 
Published: March 2019

AbstractG2/M-arrested proximal tubular epithelial cells (TECs) after renal injury are linked to increased cytokines production. ATG5-mediated autophagy in proximal TECs has recently been shown to protect against G2/M cell cycle arrest and renal fibrosis. However, the impacts of autophagy in regulating inflammatorily response mounted by injured TECs remains largely unknown. In the present study, we investigated whether ATG5 acts as an innate immune suppressor in proximal TECs during kidney injury. Using the unilateral ureteric obstruction model in proximal tubule-specific autophagy-deficient mice, we demonstrated that ablation of epithelial ATG5 genes markedly impaired autophagy, resulting in enhanced nuclear factor κB (NF-κB) activation, macrophage and lymphocyte infiltration, and proinflammatory cytokines production in obstructed kidneys, as compared with wild-type mice. Following stimulation with angiotensin II (Ang II), siRNA silencing of ATG5 in cultured HK-2 cells or ATG5-deficient primary proximal TECs produced more cytokines, including IL-1β, IL-6, and TNF-α than did their control cells. Overexpressed ATG5, but not the autophagy-incompetent ATG5 mutant K130R in HK-2 cells, rendered resistant to Ang II-induced inflammatory response. Immunofluorescence assay indicated that ATG5 and p65 colocalized in the nucleus and cytoplasm, and their interaction was verified in immunoprecipitation assay from HEK-293T cell extracts. Genetic downregulation of endogenous ATG5 increased Ang II-induced phosphorylation and nuclear translocation of p65 and transcriptional activity of NF-κB, whereas the overexpressed ATG5, rather than ATG5 mutant K130R, hampered activation of NF-κB signaling, suggest an autophagy-dependent anti-inflammatory effect of ATG5. Further, pharmacological manipulation of autophagy yielded similar results both in vivo and in vitro. Additionally, JSH-23, a specific inhibitor of NF-κB nuclear translocation, rescued Ang II-driven IL-1β production in ATG5 siRNA-treated cells and decreased the proportion of cells in G2/M phase. In conclusion, ATG5-mediated autophagy in tubules targets NF-κB signaling to protect against renal inflammation.
RBCK1 promotes p53 degradation via ubiquitination in renal cell carcinoma
Authors: Yu Sifan , Dai Jie , Ma Meng , Xu Tianxiao , Kong Yan , Cui Chuanliang , Chi Zhihong , Si Lu , Tang Huan , Yang Lu , Sheng Xinan , Guo Jun 
Published: March 2019

AbstractRenal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies, and the incidence of RCC continues to rise worldwide. Although RCC can be treated with surgery at an early stages, the five-year survival rates have been observed to decline dramatically in patients with advanced disease. Most patients with RCC treated with cytotoxic or targeted drugs will develop resistance at some point during therapy. Thus, it is necessary to identify novel therapeutic targets for RCC. Here, we found that RANBP2-type and C3HC4-type zinc finger-containing 1 (RBCK1) expression was upregulated in human RCC samples. Analysis of multiple public databases revealed the correlation between RBCK1 expression and poor prognosis in RCC patients. Subsequently, we performed RBCK1 depletion experiments in RCC cells that severely affected the in vivo and in vitro proliferation of renal cancer cells. The effects of RBCK1 on cell proliferation could be rescued with p53 expression knockdown in two cell lines expressing wild-type p53. Further experiments demonstrated that RBCK1 could facilitate p53 poly-ubiquitination and degradation by direct interaction with p53. Together, our results show that RBCK1 may serve as a promising target for RCC therapy by restoring p53 functions.
Sulforaphane metabolites inhibit migration and invasion via microtubule-mediated Claudins dysfunction or inhibition of autolysosome formation in human non-small cell lung cancer cells
Authors: Zheng Zhongnan , Lin Kai , Hu Yabin , Zhou Yan , Ding Xiaoyan , Wang Yalin , Wu Wei 
Published: March 2019

AbstractBoth sulforaphane-cysteine (SFN-Cys) and sulforaphane-N-acetyl-l-cysteine (SFN-NAC) inhibited cancer migration and invasion, but the underlying mechanisms were not clear. Here we uncovered via tissue microarray assay that high expression of invasion-associated Claudin-5 was correlated to malignant grades in human non-small cell lung cancer (NSCLC) cells. Further, SFN-Cys (10 µM) induced the accumulated phosphorylation of ERK1/2, leading to downregulation of Claudin-5 and upregulation of Claudin-7, and the decrease of Claudin-1 in SK-1 cells and increase of Claudin-1 in A549 cells; knockdown of Claudin-5 significantly reduced invasion, whereas knockdown of Claudin-7 increased invasion; knockdown of Claudin-1 reduced invasion in SK-1 cells, whereas it increased invasion in A549 cells, indicating that SFN-Cys regulated Claudins and inhibited invasion depending on Claudin isotypes and cell types. Furthermore, immunofluorescence staining showed that SFN-Cys triggered microtubule disruption and knockdown of α-tubulin downregulated Claudin-1, 5, and 7, and inhibited migration and invasion, indicating that microtubule disruption contributed to invasive inhibition. Co-immunoprecipitation and confocal microscopy observation showed that SFN-Cys lowered the interaction between α-tubulin and Claudin-1 or 5, or 7. Meanwhile, Western blotting and immunofluorescence staining showed that SFN-NAC (15 µM) downregulated α-tubulin resulting in microtubule disruption; knockdown of α-tubulin increased SFN-NAC-induced LC3 II accumulation in SK-1 cells. Combined with the inhibitor of autolysosome formation, Bafilomycin A1 (100 nM), SFN-NAC inhibited invasion via accumulating LC3 II and blocking formation of autolysosome. Further, SFN-NAC upregulated microtubule-stabilizing protein Tau; knockdown of Tau reduced LC3 II/LC3 I inhibiting migration and invasion. These results indicated that SFN-Cys inhibited invasion via microtubule-mediated Claudins dysfunction, but SFN-NAC inhibited invasion via microtubule-mediated inhibition of autolysosome formation in human NSCLC cells.