bluuebunny/crossref_metadata_2025_split huggingface dataset:
Affectively Biased Competition: Sustained Attention is Tuned to Rewarding Expressions and is Not Modulated by Norepinephrine Receptor Gene Variant
Authors: Roberts Kevin H. , Manaligod Maria G. M. , Ross Colin J. D. , Müller Daniel J. , Wieser Matthias J. , Todd Rebecca M. 
Published: September 2019

It is well established that emotionally salient stimuli evoke greater visual cortex activation than neutral ones, and can distract attention from competing tasks. Yet less is known about underlying neurobiological processes. As a proxy of population level biased competition, EEG steady-state visual evoked potentials are sensitive to competition effects from salient stimuli. Here we wished to examine whether individual differences in norepinephrine activity play a role in emotionally-biased competition.
Our previous research has found robust effects of a common variation in the ADRA2B gene, coding for alpha2B norepinephrine (NE) receptors, on emotional modulation of attention and memory. In the present study, EEG was collected while 87 carriers of the ADRA2B deletion variant and 95 non-carriers (final sample) performed a change detection task in which target gratings (gabor patches) were superimposed directly over angry, happy, and neutral faces. Participants indicated the number of phase changes (0–3) in the target. Overlapping targets and distractors were flickered at a distinct driving frequencies. Relative EEG power for faces vs. targets at the driving frequency served as an index of cortical resources allocated to each of the competing stimuli. Deletion carriers and non-carriers were randomly assigned to Discovery and Replication samples and reliability of results across samples was assessed before the groups were combined for greater power.
Overall happy faces evoked higher competition than angry or neutral faces; however, we observed no hypothesized effects of ADRA2B. Increased competition from happy faces was not due to the effect of low-level visual features or individuals low in social anxiety. Our results indicate that emotionally biased competition during sustained attention, while reliably observed in young adults, is not influenced by commonly observed individual differences linked to NE receptor function. They further indicate an overall pattern of affectively-biased competition for happy faces, which we interpret in relation to previously observed boundary conditions.
Effects of the Rulings of Constitutional Court in Time
Authors: Pūraitė-Andrikienė Dovilė 
Published: September 2019

The article analyzes the temporal effects of the Constitutional Court of the Republic of Lithuania’s rulings, i.e., ex tunc, ex nunc, and pro futuro elements of judicial decisions in the constitutional justice model of Lithuania. This article aims to reveal the development of the doctrine of exceptions of the constitutionaly established rule, that the force of the decisions of the Constitutional Court is directed to the future, in the jurisprudence of a Constitutional Court and further development of this institute inter alia in light of the 2019 amendment to the Constitution of the Republic of Lithuania, which introduced a mechanism for lodging an individual constitutional complaint.
Report Of A Project Illustrating The Feasibility Of Video/Computer Interface For Use In ESL
Authors: Stevens Vance 
Published: September 2019

This report describes a project whose purpose was to write a brief demonstration lesson in listening comprehension and then deliver that lesson using and Apple II+ computer interfaced with a Sony SL-323 Betamax video cassette recorder (VCR) using a Gentech ETS-2000 controller. The listening comprehension lesson and hardware configuration were demonstrated as part of the Rap Session on The Latest Developments in Video ESL/EFL Materials at the TESOL Convention in Honolulu, May, 1982. The report is in three parts: (1) a brief survey of video tape vs. videodisc technology, (2) a rationale for the use of interactive video in ESL, and (3) a description of the project itself. It is intended in this report to provide some background in computer interfaced video and then to give insights into some difficulties that may be encountered by computer-naïve ESL instructors wishing to prepare interactive video lessons.There are many who believe that computers will soon alter on a major scale ways that people will be able to learn. However, existing educational and media design systems may be inadequate in dealing with the demands of technologically enhanced education. Therefore, new approaches to lesson design will have to be considered. It is believed that interactive video, insofar as it is highly compatible with recent theories of learning, will be able to play a dominant role in these new approaches. However, there are technical limitations on video tape equipment which, fortunately, have been largely overcome with the development of videodisc systems. Thus, although the present project deals with video tape, both systems are compared and discussed in this article.
An observational study from a new tertiary care hospital in North Odisha: clinical and etiological profile of acute ischemic stroke patients
Authors: Behera Bibhu P. , Mohanty Partha S. 
Published: September 2019

Background: Worldwide, cerebrovascular accidents (stroke) are the second leading cause of death and the third leading cause of disability. According to WHO estimation, by 2050 nearly 80% of stroke cases may occur in low and middle-income countries like China and India. It is critical that we understand the etiology causing the stroke so that appropriate treatment can be initiated in a timely fashion. Furthermore, understanding the risk factors associated with stroke is important before primary and secondary preventive measures can be prescribed to the patient.Methods: This observational study was carried out amongst 481 acute ischemic stroke patients that fulfils the inclusion and exclusion criteria and admitted in medicine ward of Pandit Raghunath Murmu Medical College and Hospital, Baripada, Dist. Mayurbhanj, Odisha, India from June 2018 to January 2019. Results: In our study, 481(60.43%) patients had ischemic stroke and 315 (39.57%) patients had hemorrhagic stroke. The incidence of stroke is maximum in 51-70 years of age group which comprises of 59.46% of total patients. The average age + SD were 61.4±13.1 in our study. The most common risk factor was hypertension with 69.85% followed by dyslipidemia 51.77%. Most common clinical presentation was hemiplegia (72.35%) followed by speech involvement (59.46%). Most common site of infarct was parietal (22.25%), followed by periventricular (12.68%).Conclusions: Most of the patients had ischemic stroke as compared to hemorrhagic stroke. It was more common in males. The study contributes to understanding of demographic characteristics, risk factors, and stroke subtypes in acute ischemic stroke. The importance of various risk factors among ischemic stroke subtypes should be stressed for prompt preventive strategies and treatment.
High-throughput microfluidic cell sorting platform (MICS)
Authors: Philpott David , Aldridge Peter , Mair Barbara , Atwal Randy , Masud Sanna , Zhang Meng , Tong Amy H. Y. , Sargent Edward H. , Angers Stéphane , Moffat Jason , Kelley Shana 
Published: September 2019

Abstract
Genome-scale functional genetic screens can be used to interrogate determinants of protein expression modulation of a target of interest. Such phenotypic screening approaches typically require sorting of large numbers of cells (>108). In conventional cell sorting techniques (i.e. fluorescence-activated cell sorting), sorting time, associated with high instrument and operating costs and loss of cell viability, are limiting to the scalability and throughput of these screens. We recently established a rapid and scalable high-throughput microfluidic cell sorting platform (MICS) using immunomagnetic nanoparticles to sort cells in parallel capable of sorting more than 108 HAP1 cells in under one hour while maintaining high levels of cell viability (Ref. 1). This protocol outlines how to set-up MICS for large-scale phenotypic screens in mammalian cells. We anticipate this platform being used for genome-wide functional genetic screens as well as other applications requiring the sorting of large numbers of cells based on protein expression.
PET-CT Standard uptake value predict bevacizumab-containing chemotherapy response and prognosis for unresectable colorectal cancer liver-limited metastasis
Authors: Lv Yang , Feng QingYang , Tang WenTao , Xu YuQiu , Lin SongBin , Mao YiHao , Zheng Peng , Yang LiangLiang , He GuoDong , Xu JianMin 
Published: September 2019

Abstract
Background: Standard uptake value (SUV) is an indicator of tumor metabolic response. In this paper, we aim to explore the value of SUV on unresectable colorectal cancer liver-limitedmetastasis (CRLM) patients receiving bevacizumab-containing chemotherapy.
Method: This study was performed retrospectively. A total of 185 CRLM patients between April 2011 to December 2015 with complete clinical data were included in this study. All enrolled patients were assigned into two treatment cohorts (bevacizumab plus chemotherapy cohort and chemotherapy only cohort). All clinical variables, and various PET/CT parameters were statistically compared with progression-free survival (PFS) and overall survival (OS). Primary and Metastatic tumor SUV were selected for analysis.
Results: Among the 185 patients, 101 patients received chemotherapy plus bevacizumab ( beva cohort ), 84 patients only received chemotherapy ( CMT cohort ). Baseline characteristics of two cohorts showed no statistical difference (P>0.05). Primary SUV level was correlated with primary tumor size, while metastatic SUV was statistically correlated with metastatic tumor number and tumor size (P=0.000). Primary lesion, metastatic lesion SUV and elevation of SUV demonstrated prognostic role for OS (P<0.05). SUV gap were statistically associated with optimal response in beva cohort (P=0.03) and no-PD status in CMT cohort (P=0.019), respectively. After multivariate analysis, elevated SUV is an independent risk factor for OS (P=0.000). Besides, elevation of SUV between metastatic and primary lesion can be a predictive factor for bevacizumab survival benefit.
Conclusion: PET-CT scan is important for CRLM patients. Our study demonstrated that an elevation of SUV was a better prognostic and predictive marker for CRLM patients.
Hematological profile derangement in newborns as an outcome of hypertensive disorders of pregnancy.
Authors: Mtali Yohana Silas , Chamba Clara Claudius , Lyimo Magdalena Amani , Massawe Siriel Nanzia 
Published: September 2019

Abstract
Objectives This study aimed at determining the changes of hematological parameters in newborns of mothers with HDP compared to normotensive mothers.Results This was a hospital-based comparative cross-sectional study conducted from December 2017 to May 2018. The study groups consisted of 70 normotensives and 73 hypertensive pregnant women as a comparison and index group respectively. The male to female ratio for the newborns was 1:1. Newborns of the hypertensive mothers had a lower birth weight, lower APGAR score and had a lower median gestation age at the time of birth compared to the newborns of normotensive mothers (P < 0001). White blood cell and differential counts were lower in cord blood of the newborns of HDP group than in the normotensive group (P≤0.001). Approximately 50% of newborns of hypertensive mothers had thrombocytopenia. Furthermore, hypertensive disorders of pregnancy were found to independently predict neutropenia [OR=6 (2.1 – 19.4), p<0.05] and thrombocytopenia [OR=4.3(1.7 – 11.1), p<0.001] in the newborns.
Inhibition of miR-499-5p expression improves nonalcoholic fatty liver disease
Authors: Liu Hanyun , Wang Ting , Chen Xi , Jiang Jing , Song Nianhua , Li Ran , Xin Yongning , Xuan Shiying 
Published: September 2019

Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases. However, the pathogenesis of NAFLD is largely unknown. Here, we investigated the specific role of miR-499-5p in NAFLD.
Method: Free fatty acid (FFA) was used to induce HL-7702 cell line to establish a NAFLD cell model, and animal models of NAFLD were constructed by feeding C57BL/6 mice with high fat diet (HFD). Expression levels of miR-499-5p in the HL-7702 cells and C57BL/6 mice were determined by RT-qPCR. In addition, functional experiments were carried out through transfecting miR-499-5p inhibitor into NAFLD cells, and injecting NAFLD mice with a lentiviral vector with knock down the miR-499-5p . Furthermore, the effects of miR-499-5p inhibition on lipidation and inflammation were investigated by oil red O staining, HE staining, and biochemical analysis.
Results: Compared with normal controls, the expression of miR-499-5p was significantly up-regulated in NAFLD cells and tissues in mouse (P < 0.05). After NAFLD cells transfected by miR-499-5p inhibitor, the expression of miR-499-5p was inhibited, the lipid deposition and content of TG were reduced, and the lipidation was improved (P < 0.05). Simultaneously, after NAFLD mice were injected with knocked down the miR-499-5p lentiviral vector, the degree of lipid droplet deposition and content of TG were also reduced. Besides, it also decreased the levels of TC and AST in serum, and improved hepatic lipid metabolism (P < 0.05).
Conclusion: Inhibition of miR-499-5p expression improved NAFLD in mice, which provided a new direction for the treatment of NAFLD.
Lumbar Tuberculosis Treatment with Cortical Bone Trajectory Screw Fixation
Authors: Shi Shiyuan , Ying Xiaozhang , Zheng Qi , Fei Jun , Shen Jian , Zhu Bo , Jin Yanghui , Hu Shunping 
Published: September 2019

Abstract
Objective: This study aimed to investigate the clinical efficacy of a cortical bone trajectory (CBT) screw technique combined with an anterior small incision lesion removal and bone grafting for the treatment of single-segment lumbar spinal tuberculosis. Methods: A retrospective analysis of 42 patients with lumbar tuberculosis was performed. The patients were divided into two groups: intervertebral CBT screw fixation group (CBT group) and posterior pedicle screw fixation group (traditional group). Then the surgery time, bleeding volume, postoperative drainage volume, postoperative hospital stay, visual analogue scale (VAS) score, Cobb angle, neurological function (Frankel grading), and bone graft fusion time were compared between the two groups. Results: There were no significant differences between the two groups in terms of the operation times, bleeding volumes, drainage volumes, hospital stays, VAS scores, and Frankel grading. VAS scores, Cobb angles, and Frankel grading improved significantly after surgeries, without a significant difference between the two groups. At the final follow-up, no significant loss of the Cobb angle was found. All of the patients were followed up for 14 to 30 months, with a mean time of 20.8 months. The bone graft fusion time ranged from 3 to 8 months, with a mean time of 5.1 months. There were no serious complications. Conclusions: The CBT screw technique combined with an anterior small incision lesion removal and bone grafting is an effective and safe method for the treatment of lumbar tuberculosis.
Evaluation of Research Accessibility and Data Elements of HIV Registries
Authors: Mayer Craig S. , Williams Nick , Fung Kin Wah , Huser Vojtech 
Published: September 2019

Background::
Patient registries represent a long-term data collection system that is a platform
for performing multiple research studies to generate real-world evidence. Many of these registries
use common data elements (CDEs) and link data from Electronic Health Records.

Objective::
This study evaluated HIV registry features that contribute to the registry’s usability for
retrospective analysis of existing registry data or new prospective interventional studies.

Methods::
We searched PubMed and ClinicalTrials.gov (CTG) to generate a list of HIV registries.
We used the framework developed by the European Medical Agency (EMA) to evaluate the registries
by determining the presence of key research features. These features included information
about the registry, request and collaboration processes, and available data. We acquired data dictionaries
and identified CDEs.

Results:
We found 13 HIV registries that met our criteria, 11 through PubMed and 2 through CTG.
The prevalence of the evaluated features ranged from all 13 (100%) having published key registry
information to 0 having a research contract template. We analyzed 6 data dictionaries and identified
14 CDEs that were present in at least 4 of 6 (66.7%) registry data dictionaries.

Conclusion::
The importance of registries as platforms for research data is growing and the presence of
certain features, including data dictionaries, contributes to the reuse and secondary research capabilities
of a registry. We found some features such as collaboration policies were in the majority of registries
while others such as, ethical support, were in a few and are more for future development.
Tools for App- and Web-Based Self-Testing of Cognitive Impairment: Systematic Search and Evaluation
Authors: Charalambous Anna Pavlina , Pye Annie , Yeung Wai Kent , Leroi Iracema , Neil Malcolm , Thodi Chryssoula , Dawes Piers 
Published: September 2019

Background
Tools for app- and Web-based self-testing for identification of cognitive impairment are widely available but are of uncertain quality.

Objective
The objective of this study was to undertake a scoping review of app- and Web-based self-tests for cognitive impairment and determine the validity of these tests.

Methods
We conducted systematic searches in electronic databases, including Google search, Google Play Store, and iPhone Operating System App Store, using the search terms “Online OR Internet-based AND Memory OR Brain OR Dementia OR mild cognitive impairment OR MCI AND Test OR Screen OR Check.”

Results
We identified 3057 tools, of which 25 were included in the review. Most tools meeting the inclusion criteria assessed multiple cognitive domains. The most frequently assessed domains were memory, attention, and executive function. We then conducted an electronic survey with the developers of the tools to identify data relating to development and validation of each tool. If no response to the survey was received, Google (to identify gray literature), Google Scholar, and Medical Literature Analysis and Retrieval System Online were searched using key terms “(name of developer, if available)” AND “(the name of the tool)” to identify any additional data. Only 7 tools had any information concerning psychometric quality, and only 1 tool reported data on performance norms, reliability, validity, sensitivity, and specificity for the detection of cognitive impairment.

Conclusions
The number of cognitive self-assessment electronic health tools for cognitive impairment is increasing, but most are of uncertain quality. There is a need for well-validated tools and guidance for users concerning which tools provide reliable information about possible cognitive impairment that could warrant further investigation.
Effect of Cognitive Behavioral Therapy for Insomnia on Insomnia Symptoms for Individuals With Type 2 Diabetes: Protocol for a Pilot Randomized Controlled Trial
Authors: Alshehri Mohammed M , Alenazi Aqeel M , Hoover Jeffrey C , Alothman Shaima A , Phadnis Milind A , Rucker Jason L , Befort Christie A , Miles John M , Kluding Patricia M , Siengsukon Catherine F 
Published: September 2019

Background
Insomnia symptoms are a common form of sleep difficulty among people with type 2 diabetes (T2D) affecting sleep quality and health outcomes. Several interventional approaches have been used to improve sleep outcomes in people with T2D. Nonpharmacological approaches, such as cognitive behavioral therapy for insomnia (CBT-I), show promising results regarding safety and sustainability of improvements, although CBT-I has not been examined in people with T2D. Promoting sleep for people with insomnia and T2D could improve insomnia severity and diabetes outcomes.

Objective
The objective of this study is to establish a protocol for a pilot randomized controlled trial (RCT) to examine the effect of 6 sessions of CBT-I on insomnia severity (primary outcome), sleep variability, and other health-related outcomes in individuals with T2D and insomnia symptoms.

Methods
This RCT will use random mixed block size randomization with stratification to assign 28 participants with T2D and insomnia symptoms to either a CBT-I group or a health education group. Outcomes including insomnia severity; sleep variability; diabetes self-care behavior (DSCB); glycemic control (A1c); glucose level; sleep quality; daytime sleepiness; and symptoms of depression, anxiety, and pain will be gathered before and after the 6-week intervention. Chi-square and independent t tests will be used to test for between-group differences at baseline. Independent t tests will be used to examine the effect of the CBT-I intervention on change score means for insomnia severity, sleep variability, DSCB, A1c, fatigue, sleep quality, daytime sleepiness, and severity of depression, anxiety, and pain. For all analyses, alpha level will be set at .05.

Results
This study recruitment began in February 2019 and was completed in September 2019.

Conclusions
The intervention, including 6 sessions of CBT-I, will provide insight about its effect in improving insomnia symptoms, sleep variability, fatigue, and diabetes-related health outcomes in people with T2D and those with insomnia symptoms when compared with control.

Trial Registration
ClinicalTrials.gov NCT03713996; https://clinicaltrials.gov/ct2/show/NCT03713996

International Registered Report Identifier (IRRID)
DERR1-10.2196/14647