bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low‐cost and portable MRI
Authors: Wald Lawrence L. , McDaniel Patrick C. , Witzel Thomas , Stockmann Jason P. , Cooley Clarissa Zimmerman 
Published: October 2019

Research in MRI technology has traditionally expanded diagnostic benefit by developing acquisition techniques and instrumentation to enable MRI scanners to "see more." This typically focuses on improving MRI's sensitivity and spatiotemporal resolution, or expanding its range of biological contrasts and targets. In complement to the clear benefits achieved in this direction, extending the reach of MRI by reducing its cost, siting, and operational burdens also directly benefits healthcare by increasing the number of patients with access to MRI examinations and tilting its cost–benefit equation to allow more frequent and varied use. The introduction of low‐cost, and/or truly portable scanners, could also enable new point‐of‐care and monitoring applications not feasible for today's scanners in centralized settings. While cost and accessibility have always been considered, we have seen tremendous advances in the speed and spatial‐temporal capabilities of general‐purpose MRI scanners and quantum leaps in patient comfort (such as magnet length and bore diameter), but only modest success in the reduction of cost and siting constraints. The introduction of specialty scanners (eg, extremity, brain‐only, or breast‐only scanners) have not been commercially successful enough to tilt the balance away from the prevailing model: a general‐purpose scanner in a centralized healthcare location. Portable MRI scanners equivalent to their counterparts in ultrasound or even computed tomography have not emerged and MR monitoring devices exist only in research laboratories. Nonetheless, recent advances in hardware and computational technology as well as burgeoning markets for MRI in the developing world has created a resurgence of interest in the topic of low‐cost and accessible MRI. This review examines the technical forces and trade‐offs that might facilitate a large step forward in the push to "jail‐break" MRI from its centralized location in healthcare and allow it to reach larger patient populations and achieve new uses.Level of Evidence: 5Technical Efficacy Stage: 6J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2020;52:686–696.
Effective Tube Weaning and Predictive Clinical Characteristics of NICU Patients With Feeding Dysfunction
Authors: Ermarth Anna , Thomas Debbie , Ling Con Yee , Cardullo Adam , White Ben R. 
Published: October 2019

AbstractBackgroundThe present study evaluated the effectiveness of a multidisciplinary earlier discharge model for neonates receiving home enteral nutrition (HEN).MethodsA retrospective data review and analysis was performed on 183 patients discharged out of the neonatal intensive care unit (NICU) receiving partial oral feeds (PO) and partial HEN from September 2016 to March 2018. These patients were followed in a multidisciplinary clinic led by a pediatric gastroenterologist, a neonatal feeding therapist, and a pediatric dietitian. Demographics and data were recorded for patients at discharge, and then chart reviews were performed for additional data.ResultsOf 182 patients, 121 (67%) weaned off HEN with a median time to full PO at 79 days (interquartile range [IQR] 15, 247) and had median PO intake of 20% (0, 43) at time of discharge. When comparing patients who gained 100% PO vs patients who did not wean off HEN, the weaned group consisted of 88% nasogastric tubes, with median time off feeds at 27 days (IQR 8, 79) and median PO intake of 29% (11, 50) at discharge. Only 13% of the cohort had an emergency room or hospital admission, which corresponds to 1.6 and 0.8 events, respectively, per 500 tube days specifically due to HEN complications.ConclusionsOur study supports that NICU patients with feeding dysfunction can effectively and safely discharge home earlier while receiving HEN. Our data suggest that a dedicated outpatient clinic can facilitate effective tube weaning in a majority of neonates with complex medical diseases with low rates of adverse events.
Effect of in ovo feeding of β‐hydroxy‐β‐methylbutyrate on hatchability, muscle growth and performance in prenatal and posthatch broilers
Authors: Ma You‐biao , Zhang Feng‐dong , Wang Jing , Wu Shu‐geng , Qi Guang‐hai , Zhang Hai‐jun 
Published: October 2019

AbstractBACKGROUNDβ‐Hydroxy‐β‐methylbutyrate (HMB) is the metabolite of leucine that plays an important role in muscle protein metabolism. The objective of the present study was to determine the effects of in ovo feeding (IOF) of HMB at 7 days of incubation (DOI) via air cell or 18 DOI via amnion on hatchability, muscle growth and performance in prenatal and posthatch broilers.RESULTSIOF of HMB via air cell at 7 DOI increased hatchability by 4.34% compared with the control (89.67% versus 85.33%). Birds in IOF groups exhibited higher body weight, average daily body weight gain and pectoral muscle percentage. Furthermore, IOF of HMB significantly increased the level of plasma growth hormone, insulin and insulin‐like growth factor‐1. Chicks hatched from IOF treatment had larger diameters of muscle fiber and higher mitotic activity of satellite cells at early posthatch age. IOF of HMB activated satellite cells by upregulation of mRNA expression of myogenic transcription factors, myogenic differentiation one (MyoD) and myogenin. Chicks hatched from air cell injection group had higher pectoral muscle percentage at 5 d posthatch and greater satellite cell mitotic activity at 7 d posthatch than counterparts from amnion injection group.CONCLUSIONSIOF of HMB via amnion at 18 DOI or especially via air cell at 7 DOI could be used as an effective approach to enhance hatchability, productive performance and breast muscle yield in broilers. © 2019 Society of Chemical Industry
Evolution of phenolic and volatile compounds during bottle storage of a white wine without added sulfite
Authors: Pati Sandra , Crupi Pasquale , Savastano Maria L , Benucci Ilaria , Esti Marco 
Published: October 2019

AbstractBACKGROUNDBottle storage can affect color, aroma and phenolic composition of white wine. Very little information is reported about the bottle evolution during storage of white wines without added sulfites and/or using other antioxidants. This work is aimed at studying the evolution of the main enological parameters, phenolic and volatile profiles of a white wine without added sulfites, during 15 months of storage in bottle at different light and temperature conditions, compared with a control stored with sulfur dioxide. Dark storage at 12 °C (D12‐S, D12‐NS) and 30 °C (D30‐S, D30‐NS) were compared to investigate the temperature effect, meanwhile uncontrolled temperature and light condition (UTL‐S, UTL‐NS) simulated improper storage conditions.RESULTSVolatile acidity, absorbance at 420 nm and total phenols were higher in UTL‐NS and D30‐NS wines. The trans forms of hydroxycinnamic esters decreased, whereas, the cis forms, as well as caffeic acid derivatives, significantly increased in samples without added sulfites. The storage without sulfites also accelerated the hydrolysis of acetate esters. However, it did not affect most of the ethyl esters whose content remained almost the same between sulfite added (S) and no sulfite added (NS) wines.CONCLUSIONThe presence of sulfites in the bottle helped to preserve the volatile compounds of young wines; however, even more important seemed to be the optimal storage (dark and low temperature), as unsuitable conditions favored aroma degradation of bottled wine, regardless of sulfite protective action. © 2019 Society of Chemical Industry
MiR‐182‐5p enhances in vitro neutrophil infiltration in Kawasaki disease
Authors: Li Sung‐Chou , Huang Lien‐Hung , Chien Kuang‐Jen , Pan Chao‐Yu , Lin Pei‐Hsien , Lin Yuyu , Weng Ken‐Pen , Tsai Kuo‐Wang 
Published: October 2019

AbstractBackgroundKawasaki disease (KD) patients could develop coronary artery lesion (CAL) which threatens children's life. A previous study identified KD biomarker miRNAs that could discriminate KD patients from febrile non‐KD patients. We wonder whether these KD prediction biomarkers could be further applied to predict CAL formation in KD patients.MethodsTo examine this hypothesis, we conducted a meta‐analysis, miRNA mimic transfection, in vitro cell model and microarray assays.ResultsWe first showed that miR‐182‐5p and miR‐183‐5p kept higher levels in the KD patients with CAL than those without CAL (p < .05). Further machine learning alignment confirmed that CAL formation could be predicted, with an auROC value of 0.86. We further treated neutrophil cells with miR‐182‐5p mimic, followed by in vitro transendotherial migration assay. As a result, miR‐182‐5p overexpression significantly (p < .05) enhanced neutrophil cells to infiltrate the endothelial layer composed of human coronary artery endothelium cells. Further microarray assay and pathway enrichment analysis showed that the genes activated with miR‐182‐5p overexpression were significantly enriched in the leukocyte transendothelial migration pathway (kegg_pathway_194, p < .05).ConclusionTherefore, our study suggested that miR‐182‐5p enhanced in vitro leukocyte infiltration by activating the leukocyte transendothelial migration pathway in CAL formation in KD.
Novel acoustic coupling bath using magnetite nanoparticles for MR‐guided transcranial focused ultrasound surgery
Authors: Allen Steven P. , Steeves Tom , Fergusson Austin , Moore Dave , Davis Richey M , Vlaisialjevich Eli , Meyer Craig H. 
Published: October 2019

PurposeAcoustic coupling baths, nominally composed of degassed water, play important roles during transcranial focused ultrasound surgery. However, this large water bolus also degrades the quality of intraoperative magnetic resonance (MR) guidance imaging. In this study, we test the feasibility of using dilute, aqueous magnetite nanoparticle suspensions to suppress these image degradations while preserving acoustic compatibility. We examine the effects of these suspensions on metrics of image quality and acoustic compatibility for two types of transcranial focused ultrasound insonation regimes: low‐duty cycle histotripsy procedures and high‐duty cycle thermal ablation procedures.MethodsMagnetic resonance guidance imaging was used to monitor thermal ablations of in vitro gel targets using a coupling bath composed of various concentrations of aqueous, suspended, magnetite nanoparticles in a clinical transcranial transducer under stationary and flowing conditions. Thermal deposition was monitored using MR thermometry simultaneous to insonation. Then, using normal degassed water as a coupling bath, various concentrations of aqueous, suspended, magnetite nanoparticles were placed at the center of this same transducer and insonated using high‐duty cycle pulsing parameters. Passive cavitation detectors recorded cavitation emissions, which were then used to estimate the relative number of cavitation events per insonation (cavitation duty cycle) and the cavitation dose estimates of each nanoparticle concentration. Finally, the nanoparticle mixtures were exposed to low‐duty cycle, histotripsy pulses. Passive cavitation detectors monitored cavitation emissions, which were used to estimate cavitation threshold pressures.ResultsThe nanoparticles reduced the MR signal of the coupling bath by 90% in T2‐ and T2*‐weighted images and also removed almost all imaging artifacts caused by coupling bath motion. The coupling baths caused <5% changes in peak temperature change achieved during sonication, as observed via MR thermometry. At low duty cycle insonations, the nanoparticles decreased the cavitation threshold pressure by about 15 ± 7% in a manner uncorrelated with nanoparticle concentration. At high duty cycle insonations, the 0.5 cavitation duty cycle acoustic power threshold varied linearly with nanoparticle concentration.ConclusionsDilute aqueous magnetite nanoparticle suspensions effectively reduced MR imaging artifacts caused by the acoustic coupling bath. They also attenuated acoustic power deposition by <5%. For low duty cycle insonation regimes, the nanoparticles decreased the cavitation threshold by 15 ± 7%. However, for high‐duty cycle regimes, the nanoparticles decreased the threshold for cavitation in proportion to nanoparticle concentration.
Calibration of arterial spin labeling data—potential pitfalls in post‐processing
Authors: Pinto Joana , Chappell Michael A. , Okell Thomas W. , Mezue Melvin , Segerdahl Andrew R. , Tracey Irene , Vilela Pedro , Figueiredo Patrícia 
Published: October 2019

PurposeTo assess the impact of the different post‐processing options in the calibration of arterial spin labeling (ASL) data on perfusion quantification and its reproducibility.Theory and MethodsAbsolute quantification of perfusion measurements is one of the promises of ASL techniques. However, it is highly dependent on a calibration procedure that involves a complex processing pipeline for which no standardized procedure has been fully established. In this work, we systematically compare the main ASL calibration methods as well as various post‐processing calibration options, using 2 data sets acquired with the most common sequences, pulsed ASL and pseudo‐continuous ASL.ResultsSignificant and sometimes large discrepancies in ASL perfusion quantification were obtained when using different post‐processing calibration options. Nevertheless, when using a set of theoretically based and carefully chosen options, only small differences were observed for both reference tissue and voxelwise methods. The voxelwise and white matter reference tissue methods were less sensitive to post‐processing options than the cerebrospinal fluid reference tissue method. However, white matter reference tissue calibration also produced poorer reproducibility results. Moreover, it may also not be an appropriate reference in case of white matter pathology.ConclusionPoor post‐processing calibration options can lead to large errors in perfusion quantification, and a complete description of the calibration procedure should therefore be reported in ASL studies. Overall, our results further support the voxelwise calibration method proposed by the ASL white paper, particularly given the advantage of being relatively simple to implement and intrinsically correcting for the coil sensitivity profile.
Referenceless multi‐channel signal combination: A demonstration in chemical‐shift‐encoded water‐fat imaging
Authors: Liu Simin , Wu Peng , Liu Haining , Hu Zhangxuan , Guo Hua 
Published: October 2019

PurposeWithout explicit coil sensitivity information acquired by means of a reference body coil, multi‐channel signal combination for water‐fat separation (WFS) can be challenging due to channel‐dependent phase offsets and chemical‐shift dependent phase shifts. This study aims to develop a referenceless, robust, accurate, and fast channel combination method for WFS.Theory and MethodsA dual‐step multi‐channel combination method is proposed. In the first step, channel‐dependent phase offsets are estimated with a preliminary WFS estimation. In the second step, the multi‐channel data are combined after removing phase offsets. Thereafter, WFS is performed to obtain final results. Numerical simulations (4–64 coils) and in vivo experiments (8, 16, 28 coils) at 3T field strength are conducted to compare the proposed method to previous methods. Channel combination with a body‐coil scan serves as the reference for in vivo experiments.ResultsThe proposed method estimates channel‐dependent phase offsets accurately. It shows improved robustness to phase singularities than weighted mean and adaptive reconstruction. It is faster than adaptive reconstruction (e.g., 25.45 versus 46.34 s with 28 coils) and the channel‐by‐channel WFS method (e.g., 21.77 versus 50.04 s with 8 coils). It provides comparable fat quantification accuracy to the reference under various reasonable signal‐to‐noise ratio conditions (e.g., Pearson correlation coefficient r = 0.981 with P < 0.01, for in vivo fat fractions using flip angle = 10°).ConclusionThe proposed referenceless channel combination method may be beneficial to both qualitative and quantitative water‐fat imaging.
Molstack: A platform for interactive presentations of electron density and cryo‐EM maps and their interpretations
Authors: Porebski Przemyslaw J. , Bokota Grzegorz , Venkataramany Barat S. , Minor Wladek 
Published: October 2019

AbstractIn the Special Issue on Tools for Protein Science in 2018, we presented Molstack: a concept of a cloud‐based platform for sharing electron density maps and their interpretations. Molstack is a web platform that allows the interactive visualization of density maps through the simultaneous presentation of multiple datasets and models in a way that allows for easy pairwise comparison. We anticipated that the users of this conceptually simple platform would find many different uses for their projects, and we were not mistaken. We have observed researchers use Molstack to present experimental evidence for their models in the form of electron density maps, omit maps, and anomalous difference density maps. Users also employed Molstack to present alternative interpretations of densities, including rerefinements and speculative interpretations. While we anticipated these types of projects to be the main use cases, we were pleased to see Molstack used to display superpositions of different models, as a tool for story‐driven presentations, and for collaboration as well. Here, we present developments in the platform that were driven by user feedback, highlight several cases that used Molstack to enhance the publication, and discuss possible directions for the platform.
Characterization of difenoconazole resistance in Lasiodiplodia theobromae from papaya in Brazil
Authors: Li Yuan , Tsuji Susan Satie , Hu Mengjun , Câmara Marcos Paz Saraiva , Michereff Sami Jorge , Schnabel Guido , Chen Fengping 
Published: October 2019

AbstractBACKGROUNDStem‐end rot caused by Lasiodiplodia theobromae is one of the most important diseases of papaya in northeastern Brazil. It can be controlled effectively by demethylation inhibitor (DMI) fungicides, but the occurrence of DMI resistance may decrease fungicide efficacy.RESULTSDetached fruit studies revealed that isolates with EC50 values of 6.07 and 6.28 μg mL−1 were not controlled effectively, but reduced virulence and ability to grow at temperatures ranging from 12 to 32 °C suggesting fitness penalties were observed. Cross‐resistance was observed only between difenoconazole and propiconazole. The entire cytochrome P450 sterol 14α‐demethylase (LtCYP51) gene and its flanking regions were cloned. The gene was 1746 bp in length and contained three introns. The predicted protein contained 525 amino acids. Phylogenetic tree analysis showed that the LtCYP51 belongs to the CYP51B clade. No amino acid variation was found between sensitive and resistant isolates; however, the gene was constitutively more highly expressed in resistant isolates.CONCLUSIONResistance to DMI fungicides in L. theobromae is based on LtCYP51 gene overexpression and fitness penalties may be present in difenoconazole‐resistant isolates. © 2019 Society of Chemical Industry
The association of cervical sagittal alignment with adjacent segment degeneration
Authors: Yang Xiaoyu , Bartels Ronald H. M. A. , Donk Roland , Arts Mark P. , Goedmakers Caroline M. W. , Vleggeert-Lankamp Carmen L. A. 
Published: October 2019

Abstract
Purpose
Cervical spine surgery may affect sagittal alignment parameters and induce accelerated degeneration of the cervical spine. Cervical sagittal alignment parameters of surgical patients will be correlated with radiological adjacent segment degeneration (ASD) and with clinical outcome parameters.

Methods
Patients were analysed from two randomized, double-blinded trials comparing anterior cervical discectomy with arthroplasty (ACDA), with intervertebral cage (ACDF) and without intervertebral cage (ACD). C2–C7 lordosis, T1 slope, C2–C7 sagittal vertical axis (SVA) and the occipito-cervical angle (OCI) were determined as cervical sagittal alignment parameters. Radiological ASD was scored by the combination of decrease in disc height and anterior osteophyte formation. Neck disability index (NDI), SF-36 PCS and MCS were evaluated as clinical outcomes.

Results
The cervical sagittal alignment parameters were comparable between the three treatment groups, both at baseline and at 2-year follow-up. Irrespective of surgical method, C2–C7 lordosis was found to increase from 11° to 13°, but the other parameters remained stable during follow-up. Only the OCI was demonstrated to be associated with the presence and positive progression of radiological ASD, both at baseline and at 2-year follow-up. NDI, SF-36 PCS and MCS were demonstrated not to be correlated with cervical sagittal alignment. Likewise, a correlation with the value or change of the OCI was absent.

Conclusion
OCI, an important factor to maintain horizontal gaze, was demonstrated to be associated with radiological ASD, suggesting that the occipito-cervical angle influences accelerated cervical degeneration. Since OCI did not change after surgery, degeneration of the cervical spine may be predicted by the value of OCI.

NECK trial
Dutch Trial Register Number NTR1289.

PROCON trial
Trial Register Number ISRCTN41681847.

Graphic abstract
These slides can be retrieved under Electronic Supplementary Material.
A complete direct approach to nonlinear modeling of dielectric elastomer plates
Authors: Hansy-Staudigl Elisabeth , Krommer Michael , Humer Alexander 
Published: October 2019

Abstract
In this paper, we present a complete direct approach to nonlinear modeling of thin plates, which are made of incompressible dielectric elastomers. In particular, the dielectric elastomers are assumed to exhibit a neo-Hookean elastic behavior, and the effect of electrostatic forces is incorporated by the purely electrical contribution to the augmented Helmholtz free energy. Our approach does not involve any extraction-type procedure from the three-dimensional energy to derive the plate augmented free energy, but directly postulates the form of this energy for the structural plate problem treated in this paper. Results computed within the framework of this novel approach are compared to results available in the literature as well as to our own three-dimensional finite element solutions. A very good agreement is found.
A Crystal Plasticity Model with Irradiation Effect for the Mechanical Behavior of FCC Metals
Authors: Nie Junfeng , Liu Yunpeng , Lin Pandong , Xie Qihao , Liu Zhanli 
Published: October 2019

Abstract
In this paper, a crystal plasticity model considering the irradiation effect based on the thermal activation theory is established. The evolutions of screw dislocations, edge dislocations, and stacking fault tetrahedrals (SFTs) (induced by irradiation) are included into the model. The interactions between dislocations and irradiation-induced SFTs are also considered. The constitutive model is numerically implemented on the ABAQUS platform through UMAT subroutine and applied to study the irradiation effect on the mechanical behavior of pure copper. The mechanical properties of single and polycrystalline copper are studied, and the simulation results show that the constitutive model can properly predict the mechanical behavior of irradiated pure copper. Especially for polycrystalline copper, the simulation results are in good agreement with the experimental data.