bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant-inspired surfaces and interfaces for sustainable technologies
Authors: Wijerathne Binodhya , Liao Ting , Jiang Xudong , Zhou Juan , Sun Ziqi 
Published: November 2024

Abstract
The flora and fauna in nature endow the Earth with a flourishing scene of prosperity with their diverse appearances, colors and patterns, constituting common biopolymers and biominerals. The principles of construction of manifold structures and functionalities from fundamental building blocks in flora and fauna have inspired materials scientists to innovate artificial materials with superior properties and performance. Specifically, florae present numerous minute structures established from elementary blocks of lignin, cellulose, pectin and hemicellulose to induce extraordinary demands to survive in extremely diverse environments on Earth. In this review, we introduce the robust material properties and thought-provoking functionalities of plants, such as super-wettability, liquid/ion transport properties, actuation properties, etc. Then, we summarize the intriguing inspiration in the development of artificial superstructures, self-cleaning surfaces and responsive structures for applications in energy harvesting and generation, electrochemical energy storage, environmental cleaning and remediation, and strong and tough mechanical components. It is expected that some principles of how minute structures and functionalities of plants construct extraordinary capabilities and properties that could be extracted from the current progress and some insight could be offered for future material innovations by learning the best from nature.
New Frontiers of Legal Integration: Developing the Regulatory Framework of the Greater Bay Area
Authors: Migliorini Sara , Matias Célia 
Published: November 2024

Abstract
This special issue collects the insights and discussions that emerged during a conference held at the Faculty of Law of the University of Macau in May 2022. As the Greater Bay Area (GBA) evolves into a pivotal hub for economic development, it also presents a unique opportunity to explore the complexities of juxtaposing diverse legal systems within a single sovereign State. This collection of contributions from leading scholars and practitioners seeks to address the multifaceted legal challenges and opportunities inherent in the GBA’s development, focusing on topics of regulatory law. By examining these themes, we aim to foster a deeper understanding of how regulatory frameworks can be shaped to enhance cross-border cooperation and openness while respecting the distinct legal traditions of the region.
Cardiovascular status in endogenous cortisol excess: the prospective CV-CORT-EX study
Authors: Morbach Caroline , Detomas Mario , Sahiti Floran , Hoffmann Kristina , Kroiss Matthias , Gelbrich Götz , Frantz Stefan , Hahner Stefanie , Heuschmann Peter Ulrich , Fassnacht Martin , Störk Stefan , Deutschbein Timo 
Published: November 2024

Abstract

Objective
Cushing's syndrome (CS) results in increased cardiovascular (CV) morbidity and mortality. Subtype-specific differences and possible reversibility after biochemical cure are not well investigated.

Design
Prospective cohort study evaluating the CV status in different forms of endogenous cortisol excess.

Methods
Patients with overt CS (n = 40, 47 ± 13 years, 75% women; 18 pituitary, 13 adrenal, and 9 ectopic), biochemically cured CS (n = 56, 53 ± 12 years, 79% women; 30 pituitary, 21 adrenal, and 5 ectopic), and adrenal incidentalomas with mild autonomous cortisol secretion (MACS) (n = 18, 62 ± 11 years, 56% women) underwent comprehensive biochemical, metabolic, and CV assessment. Results were compared with a representative sample of the general population of Würzburg (n = 4965, 55 ± 12 years, 52% women).

Results
Overt CS was associated with left ventricular (LV) remodeling along with hypertrophy and impaired longitudinal systolic/diastolic function at echocardiography. In 20 CS patients followed for a median of 8 (quartiles: 6, 11) months after biochemical remission, hypertension, and hyperglycemia were better controlled, while cardiac alterations only partially improved. Patients with previous CS (median time of biochemical remission: 95 [36, 201] months) had worse diastolic function than the general population (LV relaxation velocity e′ 0.08 [0.07, 0.10] ms−1 vs 0.10 [0.08, 0.12] ms−1, P &lt; .001). In MACS, cardiac remodeling was even more pronounced than in individuals with metabolic syndrome.

Conclusions
In patients with overt CS, cured CS, and MACS, we found a sizable and significant deviation from the general population mean regarding cardiac structure and function. Even mild cortisol excess is associated with glucocorticoid-induced cardiac alterations, which appear to persist despite long-term biochemical remission.
Targeted multiplex proteomics for the development and validation of biomarkers in primary aldosteronism subtyping
Authors: Zhou Fangli , Ding Yun , Chen Tao , Tang Qiming , Zhang Jingjing , Thyparambil Sheeno , Jin Bo , Han Zhi , Chou C James , Schilling James , Luo Ruben Y , Tian Haoming , Sylvester Karl G , Whitin John C , Cohen Harvey J , McElhinney Doff B , Tian Li , Ling Xuefeng B , Ren Yan 
Published: November 2024

Abstract

Objective
Primary aldosteronism (PA), a significant cause of secondary hypertension affecting ∼10% of patients with severe hypertension, exacerbates cardiovascular, and cerebrovascular complications even after blood pressure control. PA is categorized into two main subtypes: unilateral aldosterone-producing adenomas (APA) and bilateral hyperaldosteronism (BHA), each requiring distinct treatment approaches. Accurate subtype classification is crucial for selecting the most effective treatment. The goal of this study was to develop novel blood-based proteomic biomarkers to differentiate between APA and BHA subtypes in patients with PA.

Design and Methods
Five subtyping differential protein biomarker candidates (APOC3, CD56, CHGA, KRT5, and AZGP1) were identified through targeted proteomic profiling of plasma. The subtyping efficiency of these biomarkers was assessed at both the tissue gene expression and blood protein expression levels. To explore the underlying biology of APA and BHA, significant differential pathways were investigated.

Results
The five-protein panel proved highly effective in distinguishing APA from BHA in both tissue and blood samples. By integrating these five protein biomarkers with aldosterone and renin, our blood-based predictive methods achieved remarkable receiver operating characteristic (ROC) area under the ROC curves of 0.986 (95% CI: 0.963-1.000) for differentiating essential hypertension from PA, and 0.922 (95% CI: 0.846-0.998) for subtyping APA versus BHA. These outcomes surpass the performance of the existing Kobayashi score subtyping system. Furthermore, the study validated differential pathways associated with the pathophysiology of PA, aligning with current scientific knowledge and opening new avenues for advancing PA care.

Conclusions
The new blood-based biomarkers for PA subtyping hold the potential to significantly enhance clinical utility and advance the practice of PA care.
The pathway to health in all policies through intersectoral collaboration on the health workforce: a scoping review
Authors: Tancred Tara , Caffrey Margaret , Falkenbach Michelle , Raven Joanna 
Published: November 2024

Abstract
The health workforce (HWF) is a critical component of the health sector. Intersectoral/multisectoral collaboration and action is foundational to strengthening the HWF, enabling responsiveness to dynamic population health demands and supporting broader goals around social and economic development—such development underpins the need for health in all policies (HiAP). To identify what can be learned from intersectoral/multisectoral activity for HWF strengthening to advance HiAP, we carried out a scoping review. Our review included both peer-reviewed and grey literature. Search terms encompassed terminology for the HWF, intersectoral/multisectoral activities and governance or management. We carried out a framework analysis, extracting data around different aspects of HiAP implementation. With the aim of supporting action to advance HiAP, our analysis identified core recommendations for intersectoral/multisectoral collaboration for the HWF, organized as a ‘pathway to HiAP’. We identified 93 documents—67 (72%) were journal articles and 26 (28%) were grey literature. Documents reflected a wide range of country and regional settings. The majority (80, 86%) were published within the past 10 years, reflecting a growing trend in publications on the topic of intersectoral/multisectoral activity for the HWF. From our review and analysis, we identified five areas in the ‘pathway to HiAP’: ensure robust coordination and leadership; strengthen governance and policy-making and implementation capacities; develop intersectoral/multisectoral strategies; build intersectoral/multisectoral information systems and identify transparent, resources financing and investment opportunities. Each has key practical and policy implications. Although we introduce a ‘pathway’, the relationship between the areas is not linear, rather, they both influence and are influenced by one another, reflecting their shared importance. Underscoring this ‘pathway’ is the shared recognition of the importance of intersectoral/multisectoral activity, shared vision and political will. Advancing health ‘for’ all policies—generating evidence about best practices to identify and maximize co-benefits across sectors—is a next milestone.
A process evaluation of a family planning, livelihoods and conservation project in Rukiga, Western Uganda
Authors: Beare Megan , Muhumuza Richard , Namanya Gift , Mayhew Susannah H 
Published: November 2024

Abstract
Although Population–Health–Environment (PHE) approaches have been implemented and studied for several decades, there are limited data on whether, how and why they work. This study provides a process evaluation of the ‘Healthy Wetlands for the Cranes and People of Rukiga, Uganda’ project, implemented by an NGO–local hospital consortium. This programme involved a research design element, testing two delivery modalities to understand the added benefit of integrating conservation, livelihoods and human health interventions, compared to delivering sector support services separately (as is more usual). The process evaluation sought to understand how the programme was implemented, the mechanisms of impact, how it was shaped by the context in which it was delivered and whether there were discernable differences across the two delivery arms. Methods involved key informant interviews with implementing staff and community educators, a review of programme documents and secondary qualitative analysis of interviews and focus groups with community members. The findings include a statistically significant increase in the reach of the programme, in both service delivery and sensitization activities, when the sectors were fully integrated. It appears that this comparative advantage of integration is because of the improved acceptability and motivation among stakeholders, and increased initiative (and agency) taken by community-based peer educators and community members. We argue that the ‘software’ of the programme underpins these mechanisms of impact: trust-based relationships embedded in the system enabled coordinated leadership, supported local staff agency and encouraged motivation.
Adding sugar to children’s beverages: a theory of planned behavior study of Lebanese mothers
Authors: Abdel Rahman Abir , Kassem Nada O F , Edwards Marc Lewis Emrys , Abdallah Bahia , Abdel Malak Rana 
Published: November 2024

Abstract
This study, guided by the theory of planned behavior (TPB), aimed to investigate whether attitude, subjective norms, and perceived behavioral control can predict parents’ intentions to reduce or stop adding sugar to their child’s beverages, such as tea or milk. The research also seeks to determine the predictive power of the TPB on the actual behavior of parents in reducing or halting sugar intake in their children’s drinks. A questionnaire was developed to assess sweetening beverage behavior variables by mothers of children aged 3–7 years attending Lebanese public schools, with 184 responses retained with no missing values for analysis. Regression analysis was utilized to examine determinants of self-reported practice and intentions regarding sweetening beverages. Results showed that attitude and perceived behavioral control were significant predictors of intention to reduce or stop adding sugar to a child's beverages. The perception of behavioral control was found to predict the behavior of adding sugar to a child’s beverages, even though the intention to reduce or stop did not. The study findings suggest that individuals with low perceived behavioral control and strong habits would be more likely to be actual performers of the adding sugar behavior regardless of their intention level. When adding sugar to a child’s beverages is a common parental habit in low-income Lebanese families, our findings offer valuable insights for developing culturally and socially tailored health promotion strategies to reduce or stop adding sugar to children’s beverages and raise parental awareness about the health risks associated with excessive sugar consumption in children.
Modelling the evolution of an ice sheet’s weathering crust
Authors: Woods Tilly , Hewitt Ian J 
Published: November 2024

Abstract
The weathering crust is a layer of porous ice that can form at the surface of an ice sheet. It grows and decays in response changing weather and climate conditions, affecting the albedo, the melt rate and the transport of meltwater across the surface. To understand this behaviour, we seek time-dependent solutions to a continuum, thermodynamic model for the porosity, temperature and thickness of the weathering crust, and the internal and surface melt rates. We find solutions using a numerical enthalpy method, presented in this study. We use idealized ‘switching’ and sinusoidal forcings to explore the different dynamics exhibited during growth and decay, the timescales involved, and the impact of diurnal vs. annual variations. The results demonstrate qualitative agreement with observations, and provide insight into the relative importance of different surface heat fluxes during the growth and decay of the crust. The model therefore provides a useful tool for exploring the response of the weathering crust to climate change.
Surgery and the first 8000 days of life: a review
Authors: Seyi-Olajide Justina , Ali Abdelbasit , Powell Jr. William F , Samad Lubna , Banu Tahmina , Abdelhafeez Hafeez , Maswime Salome , Abbas Alizeh , Ademuyiwa Adesoji , Ameh Emmanuel A , Abib Simone , Aziz Tasmiah , Bickler Stephen , Bundy Donald , Chowdhury Tanvir K , Echeto Maria A , Evans Faye , Gathuya Zipporah , Gray Rebecca , Hodges Sarah , Jamison Dean , Klazura Greg , Lakhoo Kokila , Martin Benjamin , Meara John , Nabukenya Mary , Newton Mark , Ozgediz Doruk , Rai Ekta , Philipo Godfrey S , Sykes Alicia , Yap Ava 
Published: November 2024

Abstract
The first 8000 days of life, from birth to adulthood, encompasses critical phases that shape a child's health and development. While global health efforts have focused on the first 1000 days, the next 7000 days (ages 2–21) are equally vital, especially concerning the unmet burden of surgical conditions in low- and middle-income countries (LMICs). Approximately 1.7 billion children globally lack access to essential surgical care, with LMICs accounting for 85% of these unmet needs. Common surgical conditions, including congenital anomalies, injuries, infections, and pediatric cancers, often go untreated, contributing to significant mortality and disability. Despite the substantial need, LMICs face severe workforce and infrastructure shortages, with most pediatric surgical conditions requiring specialized skills, equipment, and tailored healthcare systems. Economic analyses have shown that pediatric surgical interventions are cost-effective, with substantial societal benefits. Expanding surgical care for children in LMICs demands investments in workforce training, infrastructure, and health systems integration, complemented by innovative funding and equitable global partnerships. Prioritizing surgical care within national health policies and scaling up children's surgery through initiatives like the Optimal Resources for Children's Surgical Care can improve health outcomes, align with Sustainable Development Goals, and foster equity in global health. Addressing the surgical care gap in LMICs will reduce preventable mortality, enhance quality of life, and drive sustainable growth, emphasizing surgery as an essential component of universal health coverage for children.
Genetic parameters of functional longevity and associated traits in Italian Charolais and Limousine breeds
Authors: Callegaro Simone , Tiezzi Francesco , Maltecca Christian , Fabbri Maria Chiara , Bozzi Riccardo 
Published: November 2024

Abstract
This study aimed to estimate the genetic parameters of stayability (STAY) at different calvings using a single-step genomic best linear unbiased prediction (ssGBLUP) approach, comparing Gaussian-linear and threshold models in Italian Charolais and Limousine beef cattle. It also examined the genetic relationship between STAY and other traits to identify potential indicators of longevity and assessed the impact of STAY selection on economically important traits. STAY, a key trait for farm profitability, is defined as the probability of a cow surviving and remaining productive in the herd until a determined age. We evaluated STAY from the second to third calving and subsequent intervals (e.g., STAY23, STAY78), along with two fertility traits and several conformation traits. Data included 47,362 Limousine cows and 9,174 Charolais cows from 2,471 to 1,774 herds, respectively, born between 1977 and 2023. Analyses were performed fitting univariate threshold and Gaussian-linear animal models to estimate genetic parameters for STAY traits (STAY2 to STAY8) using ssGBLUP. Also, bivariate models were used to estimate genetic correlations between STAY and fertility and conformation traits. Heritabilities for STAY ranged from 0.13 to 0.11 and from 0.21 to 0.14 for Limousine, and from 0.14 to 0.11 and from 0.21 to 0.19 for Charolais, using Gaussian-linear and threshold models, respectively. Significant re-ranking of genotyped sires based on STAY traits was observed, particularly for more distant calvings (STAY8) compared to earlier ones (STAY3), indicating that STAY traits are genetically distinct. Genetic correlations were positive between STAY and conformation traits for Limousine. In Charolais, many traits were uncorrelated, but some conformation traits showed positive correlations, except for rump convexity, which had negative correlations with STAY. In conclusion, the heritability estimates of STAY suggests that genetic improvement for longevity in Limousine and Charolais herds is feasible. Selecting sires with consistently high genomic breeding values for STAY across early and late calvings highlights the importance of long-term longevity. Genetic correlations indicate that selection based on conformation traits could enhance herd survival by improving cow resilience for the Limousine. Instead for the Charolais some conformation traits showed positive correlations with STAY, while rump convexity had negative association, potentially affecting longevity.
Cellular senescence: mechanisms and relevance to cancer and aging
Authors: Yamauchi Shota , Takahashi Akiko 
Published: November 2024

Abstract
Cellular senescence is an irreversible cell cycle arrest induced by stresses such as telomere shortening and oncogene activation. It acts as a tumor suppressor mechanism that prevents the proliferation of potentially tumorigenic cells. Paradoxically, senescent stromal cells that arise in the tumor microenvironment have been shown to promote tumor progression. In addition, senescent cells that accumulate in vivo over time are thought to contribute to aging and age-related diseases. These deleterious effects of senescent cells involve the secretion of bioactive molecules such as inflammatory cytokines and chemokines, a phenomenon known as the senescence-associated secretory phenotype. While the role of cellular senescence in vivo is becoming increasingly clear, the intracellular signaling pathways that induce the expression of senescent phenotypes are not fully understood. In this review, we outline senescence-associated signaling pathways and their relevance to cancer and aging.
Transposable element accumulation drives genome size increase in Hylesia metabus (Lepidoptera: Saturniidae), an urticating moth species from South America
Authors: Perrier Charles , Allio Rémi , Legeai Fabrice , Gautier Mathieu , Bénéluz Frédéric , Marande William , Theron Anthony , Rodde Nathalie , Herrera Melfran , Sauné Laure , Parrinello Hugues , McClure Melanie , Arias Mónica 
Published: November 2024

Abstract
We present the first nuclear genome assembly and a complete mitogenome for Hylesia metabus (Arthropoda; Insecta; Lepidoptera; Saturniidae). The assembled nuclear genome sequence is 1,271 Mb long, which is among the 10 largest lepidopteran genome assemblies published to date. It is scaffolded in 31 pseudo chromosomes, has a BUSCO score of 99.5%, and has a highly conserved synteny compared with phylogenetically close species. Repetitive elements make up 67% of the nuclear genome and are mainly located in intergenic regions, among which LINEs were predominant, with CR1-Zenon being the most abundant. Phylogenetic and comparative analyses of H. metabus assembly and 17 additional Saturniidae and Sphingidae assemblies suggested that an accumulation of repetitive elements likely led to the increased size of H. metabus’ genome. Gene annotation using Helixer identified 26,122 transcripts. The Z scaffold was identified using both a synteny analysis and variations of coverage for two resequenced male and female H. metabus. The H. metabus nuclear genome and mitogenome assemblies can be found and browsed on the BIPAA website and constitute useful resources for future population and comparative genomics studies.