bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inventarisasi Tumbuhan Famili Euphorbiaceae Di Kelurahan Mekar Mulya, Kecamatan Panyilekan, Kota Bandung
Authors: Agnie Airul Akira  , Alvi Arumi Fadila  , Aprilia Khoirunnisa Emnur  , Ateng Supriyatna  
Published: November 2024

Euphorbiaceae is a group of plants often referred to as the sap tribe. Euphorbiaceae can be used as food, firewood, medicinal plants, building materials and also as ornamental plants. This study aims to determine the distribution of species from the Euphorbiaceae family located in Mekar Mulya Village, Panyileukan District, Bandung City. The method used, namely the direct exploration method by observing morphological characteristics, species, the number of each species and distribution patterns. The results showed that there were 6 species of plants included in the Euphorbiaceae family, including 21 individuals of Euphorbia milli, 52 individual of Sauropus androgynous, 108 individuals of Manihot esculenta, 7 individuals of Codiaeum variegatum, 3 individuals of Euphorbia tithymaloides and 6 individuals of Acalypha siamenis.
Awareness of Social Engineering Attacks and their Relation to the Ability to Persuade among users of Social Networking Sites
Authors: Turki, M Alotayan, 
Published: November 2024

Aimed Education Current into Detection levels Awareness of social engineering attacks(ASEA) and their relationship to the ability to persuade users of social networking sites, and recognize the differences in In the level of awareness of social engineering attacks And the ability to persuade among social media users according to variables of age, place of residence, economic level, educational level, and the degree to which awareness of social engineering attacks affects the ability to mask by revealing the affective relationship between variables. The study sample consisted of (415) responding to the study tools. To achieve the objectives of the study, the social engineering scale was used by Vrhovec (2021). And the measure of persuasion ability by Busch et al. (2013. The results demonstrated that social media users' awareness of social engineering attacks and their ability to persuade were around average, with an overall scale average of 3.23 and an overall persuasion ability measure of 3.34. A correlation coefficient of 0.418 at the statistical significance level (α = 0.05) showed that there was a positive and statistically significant relationship between the participants' perceptions of their awareness of social engineering attacks and their ability to persuade on social networking sites. The results of the study also showed a statistically significant effect at the level of significance (α≤0.05) for the impact of awareness of social engineering attacks on the ability to persuade from the point of view of the study sample, as the correlation coefficient (R) (418), while the coefficient of determination (R2) indicates that awareness of social engineering attacks (as an independent variable) explains (17.5%) of the variation in the variable (ability to persuade) (as a dependent variable), and the rest of the percentage means that there are other independent variables that are not mentioned in The study model - or may be due to random error, and the results of the study indicated that there are no differences in the ability to persuade users of social networking sites according to variables, place of residence, economic level, educational level, as shown in the table that there are differences according to the two age variables, where it was found that there are differences between the category of 18-20 and the category of 24 and above and in favor of the category of 18-20 on the ability to convince totally. Regardless of demographic variables such age, place of residence, socioeconomic level, or level of education, the study found that knowledge of human engineering assaults was constant.
Kajian Etika Profesi Tentang Mutasi Pendeta di Jemaat GMIBM Bethesda Bangunan Wuwuk Wilayah Modayag
Authors: Sumakul Henny W. B. , Lengkong Syalomita Herlin 
Published: November 2024

Membahas tentang profesi Pendeta sudah banyak dilakukan oleh peneliti ataupun para teolog. Namun membahas tentang etika pendeta dalam rangka penempatan dan mutasinya dalam sebuah sinode masih jarang dijumpai. Artikel ini bertujuan membahas tentang Mutasi Pendeta dalam hubungannya dengan profesi dan panggilan kependetaannya yang mendapat tugas dari Sinode gereja di GMIBM Bethesda Bangunan Wuwuk.. Persoalannya adalah apakah pendeta yang telah ditetapkan juga menaati suatu aturan yang berlaku sebab akan berdampak dalam pelayanan di jemaat. Sehingga dalam masalah ini memiliki dampak yang luar biasa dalam pelayanan dan pembangunan. Penelitian ini menggunakan metode kualitatif untuk menunjang penelitian yaitu observasi, wawancara, dan studi kepustakaan. Hasil penelitian ini memberikan pemahaman yang lebih dalam tentang panggilan kependetaan yang terikat juga dengan aturan dan ketetapan gereja termasuk mutasi pendeta. Tesis saya adalah Pendeta juga terikat dalam suatu peraturan dalam organisasi gereja dalam hal ini sinode dimana segala ketentuan dan aturan yang berlaku haruslah dipatuhi.
Low-cost Biochar from Parthenium Hysterophorus for Efficient Cr⁶⁺ Removal: A Sustainable Wastewater Treatment Solution
Authors: Naudiyal Nishtha , Srivastava R K 
Published: November 2024

Aims: This study explores the development of innovative, cost-effective methods for removing Cr6+ from wastewater, focusing on biochar derived from Parthenium hysterophorus shoots. The biochar was prepared using a conventional slow-pyrolysis process and evaluated for its potential to treat Cr⁶⁺ in aqueous solutions.
Study Design: Batch adsorption experiments are carried out in the study.
Place and Duration of Study: The study was conducted in the Department of Environmental Science, G B Pant University of Agriculture & Technology, between Feb 2024 and July 2024.
Methodology: Parthenium hysterophorus shoots were collected, reagents were purchased from HiMedia, and Cr⁶⁺ solutions were prepared and adjusted using NaOH and HCl. Shoots were washed, sun-dried, ground into powder and pyrolysed at 350°C for 180 minutes. Biochar yield was calculated, pH, proximal parameters (moisture, volatile matter, ash, fixed carbon) and ultimate analysis were measured, chemical functional groups by FTIR and morphology by XRD using Bruker D8 Advance was done. Cr⁶⁺ removal was studied using biochar adsorbent under varying pH, initial Cr6+ concentration, adsorbent dose and contact time, adsorption capacity (q) and removal percentage were then calculated.
Results: Characterization techniques such as Fourier Transform Infrared (FTIR) spectroscopy and X-Ray Diffraction (XRD) confirmed the presence of multiple functional groups and crystalline structures, which contribute to its adsorption efficiency. Batch adsorption experiments were conducted to investigate the influence of prepared biochar dosage, initial Cr⁶⁺ concentration, pH and contact time. The optimal removal efficiency of 72.77% was achieved under conditions of pH 10, a biochar dose of 1 g/L, an initial Cr⁶⁺ concentration of 30 mg/L and a contact time of 72 hours.
Conclusion: Although challenges remain in optimizing production and functionalization, this research highlights the potential of biochar for sustainable water treatment. Addressing production costs and practical challenges will further enhance its applicability, contributing to environmental sustainability efforts.
Formulation and Evaluation of Colon Specific Meloxicam Microcapsules for the Treatment of Arthritis
Authors: Kavitha K , KS Pavan Kumar , Ashitha  , Taj Yasmeen 
Published: November 2024

Objective: The main objective of the current study was to formulate and evaluate meloxicam-loaded microcapsules for colon-specific drug delivery using pH-dependent polymers. The emerging need for developing sustained release NSAIDs to minimize the dosing frequency was the main concern. Consequently, creating an oral sustained release formulation for the treatment of arthritis may be one method to get around this.
Methods: Eudragit RS/RL-100 polymers were used in emulsion solvent evaporation processes to create Meloxicam (MLX) microcapsules. Compatibility tests (FTIR), surface morphology by Scanning Electron Microscopy (SEM), yield, drug content, entrapment efficiency, and in vitro dissolution studies were performed on the produced MLX microcapsules.
Results: There was no interaction between the polymer and MLX, according to the IR spectra. The microcapsules were spherical in nature, which was confirmed by SEM. Normal frequency distribution MLX microcapsules were produced. The maximum drug entrapment efficiency of 94% was attained. The in vitro performance of MLX microcapsules demonstrated that the polymer concentration influenced sustained release. Furthermore, it was observed that the amount of polymer utilized regulated the release of the drug.
Conclusion: Based on the findings, it was concluded that one of the most promising formulation methods for creating colon specific drug delivery systems for the treatment of arthritis is the production of MLX microcapsules.
A drug‐repositioning screen for primary pancreatic ductal adenocarcinoma cells identifies 6‐thioguanine as an effective therapeutic agent for TPMT‐low cancer cells
Authors: Kim Inki , Choi Yeon‐Sook , Song Jae Hwi , Choi Eun A , Park Sojung , Lee Eun Ji , Rhee Je‐Keun , Kim Song Cheol , Chang Suhwan 
Published: July 2018

Pancreatic cancer is one of the most difficult cancers to cure due to the lack of early diagnostic tools and effective therapeutic agents. In this study, we aimed to isolate new bioactive compounds that effectively kill pancreatic ductal adenocarcinoma (PDAC) cells, but not untransformed, human pancreatic ductal epithelial (HPDE) cells. To this end, we established four primary PDAC cell lines and screened 4141 compounds from four bioactive‐compound libraries. Initial screening yielded 113 primary hit compounds that caused over a 50% viability reduction in all tested PDAC cells. Subsequent triplicate, dose‐dependent analysis revealed three compounds with a tumor cell‐specific cytotoxic effect. We found that these three compounds fall into a single category of thiopurine biogenesis. Among them, 6‐thioguanine (6‐TG) showed an IC50 of 0.39–1.13 μm toward PDAC cells but had no effect on HPDE cells. We propose that this cancer selectivity is due to differences in thiopurine methyltransferase (TPMT) expression between normal and cancer cells. This enzyme is responsible for methylation of thiopurine, which reduces its cytotoxicity. We found that TPMT levels were lower in all four PDAC cell lines than in HPDE or Panc1 cells, and that knockdown of TPMT in HPDE or Panc1 cells sensitized them to 6‐TG. Lastly, we used a patient‐derived xenograft model to confirm that 6‐TG has a significant antitumor effect in combination with gemcitabine. Overall, our study presents 6‐TG as a strong candidate for use as a therapeutic agent against PDAC with low levels of TPMT.
Early Self‐Reported Pain in Juvenile Idiopathic Arthritis as Related to Long‐Term Outcomes: Results From the Nordic Juvenile Idiopathic Arthritis Cohort Study
Authors: Arnstad Ellen Dalen , Rypdal Veronika , Peltoniemi Suvi , Herlin Troels , Berntson Lillemor , Fasth Anders , Nielsen Susan , Glerup Mia , Ekelund Maria , Zak Marek , Aalto Kristiina , Nordal Ellen , Romundstad Pål Richard , Rygg Marite ,   the Nordic Study Group of Pediatric Rheumatology
Published: July 2018

ObjectiveTo study self‐reported pain early in the disease course of juvenile idiopathic arthritis (JIA) as a predictor of long‐term disease outcomes.MethodsConsecutive cases of JIA with disease onset from 1997 to 2000 from defined geographical areas of Norway, Sweden, Finland, and Denmark were prospectively enrolled in this population‐based cohort study. Self‐reported, disease‐related pain was measured on a 10‐cm visual analog scale (VAS pain). Inclusion criteria were a baseline visit with a pain score 6 months after disease onset, followed by an 8‐year study visit. Remission was defined according to Wallace et al (2004) preliminary criteria. Functional disability was measured by the Childhood Health Assessment Questionnaire and the Child Health Questionnaire Parent Form if the child was age <18 years and by the Health Assessment Questionnaire if age ≥18 years. Damage was scored using the Juvenile Arthritis Damage Index.ResultsThe final study cohort consisted of 243 participants, and 120 participants (49%) had oligoarticular onset. At baseline, 76% reported a VAS pain score >0 compared to 57% reporting at 8 years. Half of those who reported baseline pain also reported pain at 8 years but at a lower intensity. Compared to no pain, higher pain intensity at baseline predicted more pain at 8 years, more functional disability, more damage, and less remission without medication. Baseline pain predicted more use of disease‐modifying antirheumatic drugs/biologics during the disease course. Participants with oligoarticular JIA reporting pain at baseline were more likely to develop extended oligoarticular JIA or other JIA categories with an unfavorable prognosis.ConclusionEarly self‐reported, disease‐related pain among children and adolescents with JIA is common and seems to predict persistent pain and unfavorable long‐term disease outcomes.
Cost‐Effectiveness of Diet and Exercise for Overweight and Obese Patients With Knee Osteoarthritis
Authors: Losina Elena , Smith Karen C. , Paltiel A. David , Collins Jamie E. , Suter Lisa G. , Hunter David J. , Katz Jeffrey N. , Messier Stephen P. 
Published: July 2018

ObjectiveThe Intensive Diet and Exercise for Arthritis (IDEA) trial showed that an intensive diet and exercise (D+E) program led to a mean 10.6‐kg weight reduction and 51% pain reduction in patients with knee osteoarthritis (OA). The aim of the current study was to investigate the cost‐effectiveness of adding this D+E program to treatment in overweight and obese (body mass index >27 kg/m2) patients with knee OA.MethodsWe used the Osteoarthritis Policy Model to estimate quality‐adjusted life‐years (QALYs) and lifetime costs for overweight and obese patients with knee OA, with and without the D+E program. We evaluated cost‐effectiveness with the incremental cost‐effectiveness ratio (ICER), a ratio of the differences in lifetime cost and QALYs between treatment strategies. We considered 3 cost‐effectiveness thresholds: $50,000/QALY, $100,000/QALY, and $200,000/QALY. Analyses were conducted from health care sector and societal perspectives and used a lifetime horizon. Costs and QALYs were discounted at 3% per year. D+E characteristics were derived from the IDEA trial. Deterministic and probabilistic sensitivity analyses (PSAs) were used to evaluate parameter uncertainty and the effect of extending the duration of the D+E program.ResultsIn the base case, D+E led to 0.054 QALYs gained per person and cost $1,845 from the health care sector perspective and $1,624 from the societal perspective. This resulted in ICERs of $34,100/QALY and $30,000/QALY. In the health care sector perspective PSA, D+E had 58% and 100% likelihoods of being cost‐effective with thresholds of $50,000/QALY and $100,000/QALY, respectively.ConclusionAdding D+E to usual care for overweight and obese patients with knee OA is cost‐effective and should be implemented in clinical practice.
Substituting Sedentary Time With Physical Activity in Fibromyalgia and the Association With Quality of Life and Impact of the Disease: The al‐Ándalus Project
Authors: Gavilán‐Carrera Blanca , Segura‐Jiménez Víctor , Mekary Rania A. , Borges‐Cosic Milkana , Acosta‐Manzano Pedro , Estévez‐López Fernando , Álvarez‐Gallardo Inmaculada C. , Geenen Rinie , Delgado‐Fernández Manuel 
Published: July 2018

ObjectiveThere is an overall awareness of the detrimental health effects of sedentary time (ST) in fibromyalgia; however, data are limited on how replacement of ST with physical activity (PA) of different intensity may be related to health in this condition. The aim of this study was to examine how a substitution of ST with light PA (LPA) or moderate‐to‐vigorous PA (MVPA) is associated with quality of life and disease impact.MethodsThis study comprised 407 women with fibromyalgia, mean ± SD age 51.4 ± 7.6 years. The time spent in ST and PA was measured with triaxial accelerometry. Quality of life and disease impact were assessed using the Short Form 36 (SF‐36) health survey and the Revised Fibromyalgia Impact Questionnaire (FIQR), respectively. The substitution of ST with an equivalent time of LPA or MVPA and the associated outcomes were examined using isotemporal substitution analyses.ResultsSubstituting 30 minutes of ST with LPA in the isotemporal model was associated with better scores in bodily pain (B = 0.55), vitality (B = 0.74), and social functioning (B = 1.45) according to the SF‐36, and better scores at all of the domains (function, overall impact, symptoms, and total impact) of the FIQR (B ranging from –0.95 to –0.27; all P < 0.05). When ST was replaced with MVPA, better physical role (B = 2.30) and social functioning (B = 4.11) of the SF‐36 and function of the FIQR (B = –0.73) were observed (all P < 0.05).ConclusionIn regression models, allocation of time of sedentary behavior to either LPA or MVPA was associated with better quality of life and lower disease impact in women with fibromyalgia.
The Impact of Belimumab and Rituximab on Health‐Related Quality of Life in Patients With Systemic Lupus Erythematosus
Authors: Parodis Ioannis , Lopez Benavides Angie H. , Zickert Agneta , Pettersson Susanne , Möller Sonia , Welin Henriksson Elisabet , Voss Anne , Gunnarsson Iva 
Published: July 2018

ObjectiveAccumulating evidence supports an impaired health‐related quality of life (HRQoL) in patients with systemic lupus erythematosus (SLE). We investigated the effects of 2 biologic treatments on HRQoL of patients with SLE.MethodsPatients with SLE from the Karolinska University Hospital treated with belimumab (n = 34) or rituximab (n = 35) were included; normative values derived from Swedish population‐based controls matched for age and sex were used for the purpose of comparisons. Data were collected prospectively at treatment initiation and at months 3, 6, 12, and 24, using the Short Form 36 (SF‐36) health questionnaire, the Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT‐Fatigue) scale, the EuroQol 5‐dimension (EQ‐5D) instrument, and the Stanford Health Assessment Questionnaire disability index (HAQ DI).ResultsSubstantial decrements from Swedish norms were observed across all SF‐36 domains at baseline. Patients treated with belimumab reported gradual improvements in the SF‐36 physical component summary (significant from month 12; P = 0.023) and FACIT‐Fatigue (significant by month 24; P = 0.001), no changes in EQ‐5D scores, and improvements in HAQ DI by month 6 (P = 0.014). Patients treated with rituximab showed rapid improvements in the SF‐36 mental component summary and FACIT‐Fatigue by month 3 (P = 0.031 and P = 0.007, respectively), as well as improvements in EQ‐5D at month 6 (P = 0.016) and HAQ DI at month 3 (P = 0.033). Based on baseline evaluations, patients receiving antimalarial agents (n = 33) performed better in the SF‐36 social functioning (P = 0.022) and mental health (P = 0.023) domains compared to patients who did not receive antimalarial agents (n = 36).ConclusionOur results corroborated previous findings of considerable HRQoL impairments in patients with SLE. Patients' perceptions of HRQoL showed discrepant patterns over time in the 2 treatment groups and could provide additional information along with the clinical evaluation of biologic therapy in SLE. Further survey on the effects of antimalarial agents on the HRQoL of patients with SLE in larger cohorts is merited.
Most Important Frequently Asked Questions From Patients With Hip or Knee Osteoarthritis: A Best‐Worst Scaling Exercise
Authors: Claassen Aniek A. O. M. , Kremers–van de Hei Keetie C. A. L. C. , van den Hoogen Frank H. J. , van der Laan Willemijn H. , Rijnen Wim H. C. , Koëter Sander , Botman Joris , Busch Vincent J. J. F. , Schers Henk J. , van den Ende Cornelia H. M. 
Published: July 2018

ObjectiveTo collect and prioritize the frequently asked questions (FAQs) that patients with hip or knee osteoarthritis (OA) and health care professionals consider to be the most important; to identify informational needs that go beyond guideline recommendations.MethodsFAQs were collected among health care professionals and from the arthritis helpline of the Dutch Arthritis Foundation. After deleting overlapping FAQs, the remaining FAQs were prioritized by patients and health care professionals using a maximum difference scaling method. A hierarchical Bayesian method was used to calculate relative importance scores. Differences between health care professionals and patients were analyzed using independent t‐tests.ResultsA total of 28 health care professionals and the arthritis helpline provided 192 FAQs. After deleting overlapping FAQs, 60 FAQs were prioritized by 94 patients (57 [60.6%] women, mean age 67.3 years) and 122 health care professionals (67 [54.9%] women, mean age 45.7 years). The FAQ “What can I do myself to decrease symptoms and to prevent the OA from getting worse?” was prioritized as the most important by both patients and professionals. FAQs that were highly prioritized by patients but significantly different from professionals were more directed toward treatment options offered by health care professionals, whereas highly prioritized FAQs of professionals were more often focused on treatment options involving self‐management.ConclusionThe health care professionals’ perspective on informational needs differs from that of OA patients. These differences are important to address in order to achieve more active involvement of patients in their own treatment process.
Clinical Remission and Low Disease Activity Outcomes Over 10 Years in Systemic Lupus Erythematosus
Authors: Tselios Konstantinos , Gladman Dafna D. , Touma Zahi , Su Jiandong , Anderson Nicole , Urowitz Murray B. 
Published: July 2018

ObjectiveA recent study conducted by our clinical group demonstrated that low disease activity (LDA), defined as a clinical Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI‐2K) score ≤2, maintained for 12 months, confers the same risk for damage accrual as complete remission after 2 years. The aim of the present study was to assess the validity of these findings in the long term (10 years).MethodsPatients in the inception cohort of the Toronto Lupus Clinic, who had a minimum follow‐up of 10 years and no interval >18 months between consecutive visits, were included in the analysis. Prolonged clinical remission was defined based on a SLEDAI‐2K score of 0 (serology excluded), achieved within the first 5 years of enrollment and maintained for ≥10 years. Prolonged LDA was defined as SLEDAI‐2K score ≤2 (serology excluded) with the same time frame restrictions.ResultsOf 267 patients, 27 (10.1%) achieved prolonged clinical remission and 48 (18%) attained prolonged LDA. There were no differences regarding demographic, clinical, and immunologic variables at any time. The mean prednisone dose at enrollment was higher in patients in whom remission was achieved, while patients with prolonged LDA were taking antimalarials more frequently, both at enrollment and after the 10‐year time period. Cumulative damage and flare rate after 10 years, and mortality throughout follow‐up were comparable. SLE in patients in the prolonged LDA group was in complete remission for 76% of the follow‐up time.ConclusionProlonged clinical remission and LDA were demonstrated in 10.1% and 18% of our patients, respectively, and comparable outcomes were demonstrated in the long term, rendering sustained LDA an acceptable treat‐to‐target outcome in SLE.