bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zastosowanie infuzyjnego schematu chemioterapii DA-EPOCH w leczeniu chłoniaków agresywnych
Authors: Taszner Michał , Szymańska Agata , Bieniaszewska Maria 
Published: September 2018

StreszczenieWstępStandardowe leczenie chłoniaków nie-Hodgkinowskich (non-Hodgkin lymphoma, NHL) oparte jest na stosowanym od ponad 30 lat schemacie CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone). W przypadku niektórych podtypów NHL, wyniki leczenia schematami CHOP-podobnymi są niewystarczające lub wymagają zastosowania uzupełniającej radioterapii. W latach 90-tych XX wieku wprowadzono do praktyki schematy leczenia polegające na podawaniu cytostatyków w długotrwałych wlewach i dawkach dostosowanych do parametrów farmakodynamicznych.Celem pracy było przedstawienie doświadczenia jednego ośrodka w stosowaniu schematu DA-EPOCH (dose adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin) w leczeniu NHL.Materiały i metodyPoddano obserwacji 13 chorych leczonych z powodu trzech różnych podtypów NHL: pierwotnego chłoniaka śródpiersia, chloniaka „szarej strefy“ oraz anaplastycznego chłoniaka z dużych limfocytów T. Chory z NHL z komórek T otrzymał schemat DA-EPOCH, chorzy z NHL B-komórkowymi DA-EPOCH z dodatkiem rituximabu. Ocenę odpowiedzi przeprowadzono metodą pozytonowej tomografii emisyjnej.WynikiW okresie 22 miesięcy podano łącznie 94 cykle DA-EPOCH (+/-R). U wszystkich pacjentów w czasie leczenia zaobserwowano neutropenię poniżej 0,5 G/l. Spośród 13 pacjentów, u 12 oceniono odpowiedź po zakończeniu leczenia. Całkowitą odpowiedź metaboliczną uzyskano u 9 chorych, a u 2 odpowiedź częściową. Całkowity odsetek odpowiedzi wyniósł 91%. U 1 pacjentki zaobserwowano progresję NHL. Obserwowano nieznaczną toksyczność leczenia, głównie hematologiczną. Nie zaobserwowano zgonów związanych z chemioterapią.WnioskiZebrane doświadczenia pozwalają uznać schemat DA-EPOCH za bezpieczny, skuteczny i łatwy do stosowania w warunkach oddziału szpitalnego.
Penggunaan Media Komunikasi Bagi Remaja Perempuan Dalam Pencarian Informasi Kesehatan
Authors: Prasanti Ditha 
Published: September 2018

Health information becomes important, not only for the sick, the elderly, or the children, but also for young women. Especially considering the new media era that developed more sophisticated along with the development of technology in his day. Likewise, it happens with the writer's research informant who has a new method in the search for health information.The research review that has been done in this article is the use of female teen communication media in the search for health information. The purpose of this research is to know the communication media used by female teenager in searching health information.Â Â The results of the research have shown that the female teenagers who become informants of this research writer use various communication media. Among young women who are studying in health majors choose to use online journal literature only.
Pengaruh Celebrity Endorser Hamidah Rachmayanti Terhadap Keputusan Pembelian Produk Online Shop MAYOUTFIT Di Kota Bandung
Authors: Zahra Ratika , Rina Nofha 
Published: September 2018

Utilization of internet among modern society today is the use of social media. Of the many social media that are present to be consumed by modern society and one of them is Instagram useful benefits for the delivery of new information including one that is also used dalah things do business. The emergence of the phenomenon of online shopping in social media Instagram for the vigorous business conduct marketing using supporting figures or celebrities endorser as a supporter to market their products. Seeing this phenomenon, it is necessary to do a research that.Â Hamidah Rachmayanti is a celebrity endorser used by Online Shop Mayoutfit has several purposes in this research is to determine the effect of Visibility, Credibility, Attractiveness and Celebrity Endorser Effectiveness to the Decision Purchase Online Shop Mayoutfit products. This research uses quantitative method with questionnaire distribution and using multiple linear regression.Â This study concludes that the influence of Celebrity Endorser on @hamidahrachmayanti account of 52.1% can be explained by variables consisting of Visibility, Credibility, Attractiveness, and Power.Â
Pengurangan Resiko Kebakaran Hutan dan Lahan Melalui Pemetaan HGU dan Pengendalian Pertanahan (Studi Kasus Provinsi Riau)
Authors: Utami Westi , Ndaru Arga Yugan , Widyastuti Anggi , Swardiana I Made Alit 
Published: September 2018

Abstract: Oil palm plantation expansion through inappropriate land clearing usually trigger forest fire and peat land fire in Riau Province. The purpose of this paper is to find the method to reduce disaster risk through preventive activities, conducted by mapping the distribution of Cultivation Right, and was overlaid with the map of disaster risk and agrarian control through location permit and control of spatial planning. The method used to produce disaster-prone area map was quantitative scoring and weighting, using Composite Mapping Analysis (CMA) method based on the relationship between factors with the percentage of fire spot (hotspot). The results show that from the distribution of cultivation right based on the level of vulnerability in Riau Province, there are 45 location of cultivation right lies along very high-risk area of forest fire with the total area of 95.260,7 hectares (10,4%); most of the area, counted for 70,4% with the area of 647.140,3 hectares covering 143 Cultivation Right location, located on the vulnerable area of forest fire; while 19,2% of the total cultivation right area are in less vulnerable area, spreading over 25 Cultivation Right location. Intisari: Ekspansi perkebunan sawit melalui land clearing yang tidak tepat seringkali memicu terjadinya kebakaran hutan dan lahan gambut di Provinsi Riau. Pengurangan resiko bencana melalui kegiatan preventif yaitu penyusunan peta sebaran HGU dioverlaykan dengan peta tingkat kerawanan bencana serta pengendalian pertanahan melalui ijin lokasi dan pengendalian melalui RTRW merupakan tujuan dari tulisan ini. Metode yang digunakan untuk menyusun peta kerawanan bencana adalah scoring dan pembobotan dilakukan secara kuantitatif menggunakan metode Composite Mapping Analysis (CMA) berdasarkan hubungan setiap faktor terhadap persentase titik api (hotspot). Hasil analisis menunjukkan bahwa dari sebaran HGU berdasarkan tingkat kerawanan di Provinsi Riau sebanyak 45 lokasi HGU berada pada daerah sangat rawan bencana kebakaran dengan total luasan 95.260,7 ha (10,4%); sebagian besar yaitu 70,4% dengan luasan 647.160,3 ha dengan sebaran sebanyak 143 HGU berada pada kawasan ancaman rawan terhadap bencana kebakaran hutan dan lahan; sementara 19,2% dari total luasan HGU berada pada kategori kurang rawan yang tersebar pada 25 HGU.
Statistical Experimental Design for the Extraction of Ti(IV) in the Ti(IV)-SO<sub>4</sub><sup>2-</sup> (H<sup>+</sup>, Na<sup>+</sup>) – Cyanex 301 – Kerosene – 5% (v/v) Heptane-1-ol System
Authors: Biswas R. K. , Karmakar A. K. 
Published: September 2018

The titled system has been investigated from the modelling point of view. The equilibration time for the system is 45 min, and 5% (v/v) heptane-1-ol in the organic phase is used as a de-emulsifier. The factors affecting the extent of extractions are [Ti(IV)], pH(eq), [Cyanex 301], [SO42-] and temperature (T). The selected levels are high (+) and low (-) for these factors in the present investigation. Model equation for the extraction of Ti(IV) by Cyanex 301 is determined from 25 full factorial design. However, the success of the factorial design depends on the linear relationship between yield and factor. Plots of log CD vs log [Ti(IV)], pH(eq), log [Cyanex 301] and log [SO42-] are curves. Logistic functions involving these factors are considered in designing. While [Ti(IV)] < 1.00 g/L and [HA](o) > 0.10 mol/L, considered logistic functions viz. -log(1+316.2 ([Ti(IV)], mol/L)), -log (10-pH + 229 ´10-2pH), log ([HA](o), mol/L), -log (1+0.79 ([SO42-], mol/L)) and absolute temperature are abbreviated as M, P, E, S and T, respectively. Model is log CD = 5.847 + 0.964 M + 0.909 P + 2 E + 0.995 S – (1437.5/T). The experimental model illustrates that there is no interaction effect between the factors under investigation.
Nonclassical transport in highly heterogeneous and sharply contrasting media
Authors: Bolshov L A , Kondratenko P S , Matveev L V 
Published: September 2018

Abstract
We review the physical models of nonclassical transport processes in highly heterogeneous media with different types of the spatial distribution of characteristics. We discuss transport in regularly heterogeneous, fractal, and statistically homogeneous sharply contrasting media, as well as in liquid media under the condition of Rayleigh – Benard convection. The behavior of the impurity concentration in the main localization region and at asymptotically large distances from the source is analyzed. The effect on the transport regimes arising due to the presence of colloids, as well as barriers surrounding the impurity source, is investigated. An asymptotic approach to the calculation of the concentration in a medium with large-scale heterogeneities in the distribution of transport characteristics is presented.
High Burden of Sexual Dysfunction in Female Patients with Rheumatoid Arthritis: Results of a Cross-sectional Study
Authors: Puchner Rudolf , Sautner Judith , Gruber Johann , Bragagna Elia , Trenkler Andrea , Lang Gertraud , Eberl Gabriele , Alkin Alois , Pieringer Herwig 
Published: September 2018

Objective.To evaluate the effect of rheumatoid arthritis (RA) on impairing women’s sexuality regarding motivation, activity, and satisfaction, and to assess the correlation of disease-related physical impairment within sexual functioning.Methods.An anonymous survey among women with RA and healthy controls (HC) using standardized questionnaires, predominantly the Changes in Sexual Functioning Questionnaire-short form (CSFQ-14). In addition, disease activity, depression, and disability were evaluated.Results.There were 319 questionnaires distributed to patients and 306 to HC. Of these, 235 patient questionnaires (73.7%) and 180 HC questionnaires (58.8%) were returned, of which 203 and 169 were completed, respectively. Of the patients with RA, 47.8% had a total CSFQ-14 score of ≤ 41, indicating female sexual dysfunction (FSD), as compared to 14.2% of HC (p < 0.0001). The median CSFQ-14 score was lower in patients with RA [42 points, interquartile range (IQR) 36–48] than in HC (49 points, IQR 44–54; p < 0.0001), resulting in an OR of 5.53 (95% CI 3.19–9.57; p < 0.0001). After adjustment for confounders, given a higher mean age of patients (55.2 ± 11.3 yrs) than HC (47.4 ± 11.8 yrs; p < 0.0001), the OR for FSD in patients with RA was still 3.04 (95% CI 1.61–5.75; p = 0.001). Neither the Health Assessment Questionnaire–Disability Index nor the Clinical Disease Activity Index was associated with FSD after adjustment.Conclusion.FSD apparently is highly prevalent in female patients with RA, affects all subdomains of sexual function, and is most likely underestimated in daily clinical practice. Of note, FSD could not be linked to disability or RA disease activity.
Flares in Rheumatoid Arthritis Patients with Low Disease Activity: Predictability and Association with Worse Clinical Outcomes
Authors: Bechman Katie , Tweehuysen Lieke , Garrood Toby , Scott David L. , Cope Andrew P. , Galloway James B. , Ma Margaret H.Y. 
Published: September 2018

Objective.To investigate predictors of flare in rheumatoid arthritis (RA) patients with low disease activity (LDA) and to evaluate the effect of flare on 12-month clinical outcomes.Methods.Patients with RA who were taking disease-modifying antirheumatic drugs and had a stable 28-joint count Disease Activity Score (DAS28) < 3.2 were eligible for inclusion. At baseline and every 3 months, clinical (DAS28), functional [Health Assessment Questionnaire–Disability Index (HAQ-DI), EQ-5D, Functional Assessment of Chronic Illness Therapy Fatigue scale (FACIT-F), Medical Outcomes Study Short Form-36 (SF-36)], serum biomarkers [multibiomarker disease activity (MBDA) score, calprotectin, CXCL10], and imaging data were collected. Flare was defined as an increase in DAS28 compared with baseline of > 1.2, or > 0.6 if concurrent DAS28 ≥ 3.2. Cox regression analyses were used to identify baseline predictors of flare. Biomarkers were cross-sectionally correlated at time of flare. Linear regressions were performed to compare clinical outcomes after 1 year.Results.Of 152 patients, 46 (30%) experienced a flare. Functional disability at baseline was associated with flare: HAQ-DI had an unadjusted HR 1.82 (95% CI 1.20–2.72) and EQ-5D had HR 0.20 (95% CI 0.07–0.57). In multivariate analyses, only HAQ-DI remained a significant independent predictor of flare (HR 1.76, 95% CI 1.05–2.93). At time of flare, DAS28 and its components significantly correlated with MBDA and calprotectin, but correlation coefficients were low at 0.52 and 0.49, respectively. Two-thirds of flares were not associated with a rise in biomarkers. Patients who flared had significantly worse outcomes at 12 months (HAQ-DI, EQ-5D, FACIT-F, SF-36, and radiographic progression).Conclusion.Flares occur frequently in RA patients with LDA and are associated with worse disease activity, quality of life, and radiographic progression. Higher baseline HAQ-DI was modestly predictive of flare, while biomarker correlation at the time of flare suggests a noninflammatory component in a majority of events.
Canadian Rheumatology Association Recommendations for the Assessment and Monitoring of Systemic Lupus Erythematosus
Authors: Keeling Stephanie O. , Alabdurubalnabi Zainab , Avina-Zubieta Antonio , Barr Susan , Bergeron Louise , Bernatsky Sasha , Bourre-Tessier Josiane , Clarke Ann , Baril-Dionne Alexandra , Dutz Jan , Ensworth Stephanie , Fifi-Mah Aurore , Fortin Paul R. , Gladman Dafna D. , Haaland Derek , Hanly John G. , Hiraki Linda T. , Hussein Sara , Legault Kimberly , Levy Deborah , Lim Lily , Matsos Mark , McDonald Emily G. , Medina-Rosas Jorge , Pardo Pardi Jordi , Peschken Christine , Pineau Christian , Pope Janet , Rader Tamara , Reynolds Jen , Silverman Earl , Tselios Konstantinos , Suitner Manon , Urowitz Murray , Touma Zahi , Vinet Evelyne , Santesso Nancy 
Published: September 2018

Objective.To develop recommendations for the assessment of people with systemic lupus erythematosus (SLE) in Canada.Methods.Recommendations were developed using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. The Canadian SLE Working Group (panel of Canadian rheumatologists and a patient representative from Canadian Arthritis Patient Alliance) was created. Questions for recommendation development were identified based on the results of a previous survey of SLE practice patterns of members of the Canadian Rheumatology Association. Systematic literature reviews of randomized trials and observational studies were conducted. Evidence to Decision tables were prepared and presented to the panel at 2 face-to-face meetings and online.Results.There are 15 recommendations for assessing and monitoring SLE, with varying applicability to adult and pediatric patients. Three recommendations focus on diagnosis, disease activity, and damage assessment, suggesting the use of a validated disease activity score per visit and annual damage score. Strong recommendations were made for cardiovascular risk assessment and measuring anti-Ro and anti-La antibodies in the peripartum period and conditional recommendations for osteoporosis and osteonecrosis. Two conditional recommendations were made for peripartum assessments, 1 for cervical cancer screening and 2 for hepatitis B and C screening. A strong recommendation was made for annual influenza vaccination.Conclusion.These are considered the first guidelines using the GRADE method for the monitoring of SLE. Existing evidence is largely of low to moderate quality, resulting in more conditional than strong recommendations. Additional rigorous studies and special attention to pediatric SLE populations and patient preferences are needed.
DIAGNÓSTICO DERMATOPATOLÓGICO EM CÃES
Authors: Ramos Afonso Marcos Vinícius , Cardoso Jacyara Pereira , Barreto Silene Maria Prates 
Published: September 2018

Na rotina da clínica médica veterinária, destaca-se a área dermatológica, sendo responsável pela maior parte da casuística, destacando-se o setor da dermatopatologia, sendo a pele é o maior órgão do organismo, revestindo toda a superfície externa do corpo. Para a obtenção de diagnósticos mais precisos, foram utilizados exames específicos (teste de luz de Wood, teste com fita de acetato, teste com hidróxido de potássio, raspado de pele, coloração de Gram, tricograma e citologia). As dermatopatologias encontradas foram de origem bacteriana (23,08%), parasitária (23,08%), fúngicas (23,08%), de cunho imunológico (12,82%), de origem infecciosa (30,77%) e outras causas diversas (7,69%). Tais resultados possuem extrema relevância para a rotina da clínica médica de pequenos animais, uma vez que podem direcionar o atendimento pelo médico veterinário, proporcionando um tratamento com maior acurácia para as dermatopatologias.
The Domestic Violence Protection Order System as Entry to the Criminal Justice System for Aboriginal and Torres Strait Islander People
Authors: Douglas Heather , Fitzgerald Robin 
Published: September 2018

The domestic violence protection order (DVO) system is a hybrid system of criminalisation in which the DVO itself is a civil order, but any contravention of that order may result in a criminal charge. Limited attention has been paid to the potential consequences of criminalisation through the hybrid DVO system in the Australian context. We use Queensland as a case study and examine administrative data gathered through Queensland Courts. We show that a disproportionate number of Aboriginal and Torres Strait Islander (ATSI) people are named on DVOs, charged with contraventions of DVOs and significantly more likely than non-Indigenous people to receive a sentence of imprisonment for a contravention of a DVO, compared to non-Indigenous people. We find that ATSI women are particularly overrepresented in this system. We review explanations for these startling figures and emphasize the need for a change in approach.
The reduction in FOXA2 activity during lung development in fetuses from diabetic rat mothers is reversed by Akt inhibition
Authors: Zhang Qingmiao , Chai Xinqun , Deng Feitao , Ouyang Weixiang , Song Ting 
Published: September 2018

Hyperglycemia during pregnancy is associated with fetal lung development disorders and surfactant protein (SP) deficiency. Here, we examined the role of FOXA2 and Akt signaling in fetal lung development during diabetic pregnancy. Sprague‐Dawley rats were injected with streptozocin (STZ) during pregnancy to induce diabetes (DM). DM‐exposed fetal lungs exhibited reduced numbers of alveoli, irregularities in the appearance and thickness of the alveolar septum, increased levels of glycogen and lipids in type II alveolar epithelial cells, fewer microvilli and mature lamellar bodies, and swollen mitochondria. SP‐B and SP‐C in DM amniotic fluid and DM lungs were lower than in the control group (P < 0.05). DM lung nuclear FOXA2 was lower compared with the control group (P < 0.05), but p‐FOXA2 was higher (P < 0.05). In murine lung epithelial (MLE) 12 cells, p‐AKT levels were increased by high glucose/insulin, but decreased by the Akt inhibitor MK2206 (P < 0.05). Expression of nuclear FOXA2 was increased by MK2206 compared with the high glucose/insulin group (P < 0.05). These results suggest that maternal diabetes induces fetal lung FOXA2 phosphorylation through the Akt pathway, and also affects the maturation of alveolar epithelial cells and reduces levels of SP‐B and SP‐C in the fetal lungs. An Akt inhibitor reversed the changes in SP expression in vitro.
Controlling Proton and Electron Transfer Rates to Enhance the Activity of an Oxygen Reduction Electrocatalyst
Authors: Gautam Rajendra P. , Lee Yi Teng , Herman Gabriel L. , Moreno Cynthia M. , Tse Edmund C. M. , Barile Christopher J. 
Published: September 2018

AbstractAn electrochemical approach is developed that allows for the control of both proton and electron transfer rates in the O2 reduction reaction (ORR). A dinuclear Cu ORR catalyst was prepared that can be covalently attached to thiol‐based self‐assembled monolayers (SAMs) on Au electrodes using azide–alkyne click chemistry. Using this architecture, the electron transfer rate to the catalyst is modulated by changing the length of the SAM, and the proton transfer rate to the catalyst is controlled with an appended lipid membrane modified with proton carriers. By tuning the relative rates of proton and electron transfer, the current density of the lipid‐covered catalyst is enhanced without altering its core molecular structure. This electrochemical platform will help identify optimal thermodynamic and kinetic parameters for ORR catalysts and catalysts of other reactions that involve the transfer of both protons and electrons.
Downregulation of exosome‐encapsulated miR‐548c‐5p is associated with poor prognosis in colorectal cancer
Authors: Peng Zhi‐Yong , Gu Run‐Huan , Yan Bin 
Published: September 2018

AbstractThe role of circulating exosomal microRNAs (miRNAs) in colorectal cancer (CRC) has drawn more and more attention during the past few years. Previously, we have identified several specific miRNAs in serum exosomes as potential CRC biomarkers. However, little is known about the association between exosome‐encapsulated miR‐548c‐5p and outcomes of patients with CRC. In the current study, the expression of serum exosomal miR‐548c‐5p was investigated by quantitative real‐time polymerase chain reaction. Its correlation with CRC prognosis was estimated by Kaplan‐Meier survival and log‐rank tests. Cox regression analysis based on uni‐ and multivariate analyses was performed to estimate the relationship of exosome‐encapsulated miR‐548c‐5p with the clinicopathological factors of patients with CRC. Reduced levels of serum exosomal miR‐548c‐5p were more significant in CRC patients with liver metastasis and at later TNM stage (III/IV tumor stages). Serum exosomal miR‐548c‐5p could inhibit the proliferation of CRC cells, while the precise molecular mechanisms warranted further elucidation. In addition, decreased levels of serum exosomal miR‐548c‐5p were independently associated with shorter overall survival in CRC adjusted by age, sex, tumor grade vascular infiltration, TNM stage (III/IV tumor stages) and metastasis (hazard ratio = 3.40, 95% confidence interval 1.02‐11.27; P = 0.046). The downregulation of exosomal miR‐548c‐5p in serum predicts poor prognosis in patients with CRC. Exosomal miR‐548c‐5p may be a critical biomarker for CRC diagnosis and prognosis.