bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of static space occupied by individual weaner and growing pigs using an image-based monitoring system
Authors: Fels M. , Konen K. , Hessel E. , Kemper N. 
Published: March 2018

AbstractIn the present study, precise, animal-based biometric data on the space needed for the body dimensions of individual pigs (static space) were collected. Per batch, two groups of eight piglets each were formed after weaning (35 days old). Using three-dimensional cameras that recorded a piglets’ pen from above and newly developed software, the static space of individuals was determined over 6 weeks. The area covered by an individual increased almost linearly with increasing body weight (R2= 0.97). At the end of rearing (25 kg body weight), an individual covered 1704 cm2in standing position, 1687 cm2in sitting posture and 1798 cm2in a recumbent position. According to the allometric equation: Space =k× body weight0.667,kvalues for the static space in standing position (k= 0.021), in recumbent position in general (k= 0.022) and in lateral recumbent posture (k= 0.027) were calculated. Compared with spatial requirements in different countries, the results of static space obtained in the present study revealed that pigs weighing 25 kg are provided with 0.09–0.18 m2free space per pig which is not covered by the pig's body. This free space can be used as dynamic space needed for body movements or social interactions. The present study was not intended to enhance space recommendations in pig farming, but to demonstrate the amount of free space in a pigs’ pen. It was shown that innovative technologies based on image analysis offer completely new possibilities to assess spatial requirements for pigs.
Why the Liberal World Order Will Survive
Authors: Ikenberry G. John 
Published: March 2018

AbstractThe crisis of the American-led international order would seem to open up new opportunities for rising states—led by China, India, and other non-Western developing countries—to reshape the global order. As their capacities and influence grow, will these states rise up and integrate into the existing order or will they seek to overturn and reorganize it? The realist hegemonic perspective expects today's power transition to lead to growing struggles between the West and the “rest” over global rules and institutions. In contrast, this essay argues that although America's hegemonic position may be declining, the liberal international characteristics of order—openness, rules, and multilateralism—are deeply rooted and likely to persist. And even as China seeks in various ways to build rival regional institutions, there are stubborn limits on what it can do.
Validation of the Brief Developmental Assessment in pre-school children with heart disease
Authors: Brown Katherine L. , Ridout Deborah A. , Pagel Christina , Lakhanpaul Monica , Kakat Suzan , Banks Victoria , Franklin Rodney , Witter Thomas , Lakhani Rhian , Tibby Shane , Anderson David , Tsang Victor , Hoskote Aparna U. , Wray Jo 
Published: March 2018

AbstractIntroductionThe objective of this study was to prospectively validate the “Brief Developmental Assessment”, which is a new early recognition tool for neurodevelopmental abnormalities in children with heart disease that was developed for use by cardiac teams.MethodsThis was a prospective validation study among a representative sample of 960 pre-school children with heart disease from three United Kingdom tertiary cardiac centres who were analysed grouped into five separate age bands.ResultsThe “Brief Developmental Assessment” was successfully validated in the older four age bands, but not in the youngest representing infants under the age of 4 months, as pre-set validation thresholds were met – lower 95% confidence limit for the correlation coefficient above 0.75 – in terms of agreement of scores between two raters and with an external measure the “Mullen Scales of Early Learning”. On the basis of American Association of Pediatrics Guidelines, which state that the sensitivity and specificity of a developmental screening tool should fall between 70 and 80%, “Brief Developmental Assessment” outcome of Red meets this threshold for detection of Mullen scores >2 standard deviations below the mean.ConclusionThe “Brief Developmental Assessment” may be used to improve the quality of assessment of children with heart disease. This will require a training package for users and a guide to action for abnormal results. Further research is needed to determine how best to deploy the “Brief Developmental Assessment” at different time points in children with heart disease and to determine the management strategy in infants younger than 4 months old.
Alerting observations of asteroids at the SBG telescope of the Kourovka Astronomical Observatory in the Gaia-FUN-SSO Network
Authors: Kuznetsov Eduard , Glamazda Dmitry , Kaiser Galina , Wiebe Yulia 
Published: March 2018

AbstractRegular astrometric observations of small bodies of the Solar System are conducted using a SBG telescope of the Kourovka Astronomical Observatory of the Ural Federal University. The first results of participation in Gaia-FUN-SSO network are presented.
Using Gaia spectrophotometric data for the purposes of asteroid taxonomy
Authors: Cellino Alberto , Tanga Paolo , Delbo Marco , Galluccio Laurent , Bendjoya Philippe , De Angeli Francesca 
Published: March 2018

AbstractA new asteroid taxonomy will be an important result of Gaia observations of Solar System objects. Since Gaia observes asteroids in observing conditions and in an interval of wavelength which are slightly different with respect to normal ground-based observations, a dedicated observing campaign has been carried out at the Telescopio Nazionale Galileo in La Palma (Canary Islands, Spain). The obtained spectra have been used to generate a large number of synthetic clones, each one having slight changes with respect to its parent spectrum. These synthetic spectra are then used to feed the algorithm of taxonomic classification developed to reduce Gaia asteroid spectra. Processing of these data is in progress.
The mass-ratio distribution of spectroscopic binaries along the main-sequence
Authors: Boffin Henri M. J. , Pourbaix Dimitri 
Published: March 2018

AbstractBinarity is now a well-established quality affecting a large fraction of stars, and recent studies have shown that the fraction of binaries is a function of the spectral type of the primary star, with most massive stars being member of a close binary system. By cross-matching TGAS with SB9, we went one step further and derived the mass ratio distribution of binary systems as a function of the spectral type of the primary star. This, combined with the binary fraction, provides very strong constraints on star formation and critical input for stellar population models.
The nearby triple star HIP 101955
Authors: Xia Fang 
Published: March 2018

AbstractThe nearby triple star HIP 101955 with strongly inclined orbit still remains. Thus the long-term dynamical stability deserves to be discussed based on the new dynamical state parameters (component masses and kinematic parameters) derived from fitting the accurate three-body model to the radial velocity, the Hipparcos Intermediate Astrometric Data (HIAD), and the accumulated speckle and visual data. It is found that the three-body system remains integrated and most likely undergoes Kozai cycles. With the already accumulated high-precision data, the three-body effects cannot always be neglected in the determination of the dynamical state. And it is expected that this will be the general case under the available Gaia data.
Solar system astrometry, Gaia, and the large surveys – a huge step ahead to stellar occultations by distant small solar system bodies
Authors: Camargo J. I. B. , Banda-Huarca M. V. , Ogando R. L. , Desmars J. , Braga-Ribas F. , Vieira-Martins R. , Assafin M. , Sicardy B. , Bérard D. , Benedetti-Rossi G. , da Costa L. A. N. , Maia M. A. G. , Carrasco-Kind M. , Drlica-Wagner A. 
Published: March 2018

AbstractThe stellar occultation technique is a powerful tool to study distant small solar system bodies. Currently, around 2 500 trans-neptunian objects (TNOs) and Centaurs are known. With the astrometry from Gaia and large surveys like the Large Synoptic Survey Telescope (LSST), accurate predictions of occultation events will be available to tens of thousands of TNOs and Centaurs and boost the knowledge of the outer solar system.
S stars in the Gaia era: stellar parameters and nucleosynthesis
Authors: Van Eck Sophie , Karinkuzhi Drisya , Shetye Shreeya , Jorissen Alain , Goriely Stéphane , Siess Lionel , Merle Thibault , Plez Bertrand 
Published: March 2018

AbstractS stars are s-process and C-enriched (0.5<C/O<1) red giants. Their abundances can be determined thanks to a new grid of MARCS model atmospheres covering their whole parameter range. Detailed abundance determinations in intrinsic S stars (TP-AGB) and extrinsic S stars (binary masqueraders) can provide strong constraints on the s-process nucleosynthesis: in particular, the s-process temperature can be determined using zirconium and niobium abundances, independently of stellar evolution models. Synthetic spectra of dwarf S stars have been computed and will be sought for in spectroscopic survey data, constraining their luminosity thanks to Gaia parallaxes.
Prospects for asteroid mass determination from close encounters between asteroids: ESA's Gaia space mission and beyond
Authors: Ivantsov Anatoliy , Hestroffer Daniel , Eggl Siegfried 
Published: March 2018

AbstractWe present a catalog of potential candidates for asteroid mass determination based on mutual close encounters of numbered asteroids with massive perturbers (D>20 km). Using a novel geometric approach tuned to optimize observability, we predict optimal epochs for mass determination observations. In contrast to previous studies that often used simplified dynamical models, we have numerically propagated the trajectories of all numbered asteroids over the time interval from 2013 to 2023 using relativistic equations of motion including planetary perturbations, J2 of the Sun, the 16 major asteroid perturbers and the perturbations due to non-sphericities of the planets. We compiled a catalog of close encounters between asteroids where the observable perturbation of the sky plane trajectory is greater than 0.5 mas so that astrometric measurements of the perturbed asteroids in the Gaia data can be leveraged. The catalog v1.0 is available at ftp://dosya.akdeniz.edu.tr/ivantsov.
The kinematics and surface mass density in the solar neighbourhood using TGASxRAVE
Authors: Hagen Jorrit H. J. , Helmi Amina 
Published: March 2018

AbstractWe investigate the kinematics of stars in the Solar neighbourhood by combining radial velocities from the latest data release of the RAVE survey with the Tycho-Gaia Astrometric Solution presented in Gaia Data Release 1. We use moments of the velocity distribution to characterise the kinematics over a radial distance range of 6-10 kpc and up to 1 kpc away from the plane. Our ultimate goal is to use these to put new constraints on the (local) distribution of mass using the Jeans Equations.
Observations of the satellites of the major planets at Pulkovo Observatory: history and present
Authors: Shakht N. A. , Devyatkin A. V. , Gorshanov D. L. , Chubey M. S. 
Published: March 2018

AbstractIn connection with long on-orbit European space satellite Gaia and the opportunity that now provides ESA, to use the results of observations of the space telescope, we would like to present some results of our long-term observations of the major planets satellites at Pulkovo Observatory. We hope to translate into reality these opportunities, namely the use of new observations and new ephemeris and a practical possibility of a new reduction for modern and old observations. The essential facilities can appear in the space, we give the shortest presentation of space project Orbital Stellar Stereoscopic Observatory.
The Gaia mission status
Authors: Prusti T. 
Published: March 2018

AbstractGaia is an ESA cornerstone mission conducting a full sky survey over its 5 year operational period. Gaia performs astrometric, photometric and spectroscopic measurements. The data processing is entrusted to scientists and engineers who have formed the Gaia Data Processing and Analysis Consortium (DPAC). The photometric science alerts started in 2014. The first intermediate data release (Gaia DR1) took place 14 September 2016 and it has been extensively used by the community. Gaia DR2 is scheduled for April 2018. Gaia is expected to be able to continue observations roughly for another 5 years after the nominal phase. The procedure to grant funding for the extension period has been initiated. In case funding is granted, the total operational time of Gaia may be 10 years.
Self-consistent Modelling of the Milky Way using Gaia data
Authors: Cole David R. , Binney James 
Published: March 2018

AbstractAngle/action based distribution function (DF) models can be optimised based on how well they reproduce observations thus revealing the current matter distribution in the Milky Way. Gaia data combined with data from other surveys, e.g. the RAVE/TGAS sample, and its full selection function will greatly improve their accuracy.
Complex study of the open cluster NGC 2281
Authors: Velčovský Jaroslav , Janík Jan 
Published: March 2018

AbstractWe present the complex study of the open cluster NGC 2281 where both traditional and newly developed methods for study of open clusters have been used. Morphological and dynamical parameters of the cluster were obtained from the accepted astrometric data. The new method “Superposition of Gaussian surfaces” along with proper motion of stars was used to determine membership probabilities which were helpful in selection of stars for further analysis. Metallicity and radial velocity of the cluster were obtained from spectroscopic measurements. Age, colour excess, and distance of the cluster were determined using absolute CCD photometry combined with previous results. The results were compared with those of previous studies.
Chemo-dynamical signatures in simulated Milky Way-like galaxies
Authors: Spagna Alessandro , Curir Anna , Giammaria Marco , Lattanzi Mario G. , Murante Giuseppe , Fiorentin Paola Re 
Published: March 2018

AbstractWe have investigated the chemo-dynamical evolution of a Milky Way-like disk galaxy, AqC4, produced by a cosmological simulation integrating a sub-resolution ISM model. We evidence a global inside-out and upside-down disk evolution, that is consistent with a scenario where the “thin disk” stars are formed from the accreted gas close to the galactic plane, while the older “thick disk” stars are originated in situ at higher heights. Also, the bar appears the most effective heating mechanism in the inner disk. Finally, no significant metallicity-rotation correlation has been observed, in spite of the presence of a negative [Fe/H] radial gradient.
Abundance ratios & ages of stellar populations in HARPS-GTO sample
Authors: Mena E. Delgado , Tsantaki M. , Zh. Adibekyan V. , Sousa S. G. , Santos N. C. , Hernández J. I. González , Israelian G. 
Published: March 2018

AbstractIn this work we present chemical abundances of heavy elements (Z>28) for a homogeneous sample of 1059 stars from HARPS planet search program. We also derive ages using parallaxes from Hipparcos and Gaia DR1 to compare the results. We study the [X/Fe] ratios for different populations and compare them with models of Galactic chemical evolution. We find that thick disk stars are chemically disjunt for Zn adn Eu. Moreover, the high-alpha metal-rich population presents an interesting behaviour, with clear overabundances of Cu and Zn and lower abundances of Y and Ba with respect to thin disk stars. Several abundance ratios present a significant correlation with age for chemically separated thin disk stars (regardless of their metallicity) but thick disk stars do not present that behaviour. Moreover, at supersolar metallicities the trends with age tend to be weaker for several elements.
Identification of binary and multiple systems in TGAS using the Virtual Observatory
Authors: Jiménez-Esteban F. , Solano E. 
Published: March 2018

AbstractBinary and multiple stars have long provided an effective method of testing stellar formation and evolution theories. In particular, wide binary systems with separations > 20,000 au are particularly challenging as their physical separations are beyond the typical size of a collapsing cloud core (5,000 - 10,000 au). We present here a preliminary work in which we make use of the TGAS catalogue and Virtual Observatory tools and services (Aladin, TOPCAT, STILTS, VOSA, VizieR) to identify binary and multiple star candidate systems. The catalogue will be available from the Spanish VO portal (http://svo.cab.inta-csic.es) in the coming months.
How far away and how old are these stars?
Authors: McMillan Paul J. ,   the RAVE Collaboration
Published: March 2018

AbstractRAVE is the spectroscopic survey with the largest overlap with TGAS (around 200000 stars). Since RAVE's fourth data release, it has contained distance estimates based on a Bayesian estimation scheme. Here we compare these estimates to TGAS's parallaxes, to determine the strengths and weaknesses of each. We also combine the two datasets together to find more precise distance estimates for all these stars.
Dynamical masses of Cepheids from the GAIA parallaxes
Authors: Gallenne A. , Kervella P. , Mérand A. , Evans N. R. , Proffitt C. 
Published: March 2018

AbstractThe mass of a Cepheid is a fundamental parameter for studying the pulsation and evolution of intermediate-mass stars. But determining this variable has been a long-standing problem for decades. Detecting the companions (by spectroscopy or imaging) is a difficult task because of the brightness of the Cepheids and the close orbit of the components. So most of the Cepheid masses are derived using stellar evolution or pulsation modeling, but they differ by 10-20 %. Measurements of dynamical masses offer the unique opportunity to make progress in resolving this mass discrepancy.The first problem in studying binary Cepheids is the high contrast between the components for wavelengths longer than 0.5 μm, which make them single-line spectroscopic binaries. In addition, the close orbit of the companions (<40 mas) prevents us from spatially resolving the systems with a single-dish 8m-class telescope. A technique able to reach high spatial resolution and high-dynamic range is long-baseline interferometry. We have started a long-term program that aims at detecting, monitoring and characterizing physical parameters of the Cepheid companions. The GAIA parallaxes will enable us to combine interferometry with single-line velocities to provide unique dynamical mass measurements of Cepheids.
The Gaia Archive
Authors: Mora Alcione , González-Núñez Juan , Baines Deborah , Durán Javier , Gutiérrez-Sanchéz Raúl , Racero Elena , Salgado Jesús , Segovia Juan Carlos 
Published: March 2018

AbstractThe Archive is the main Gaia data distribution hub. The contents of DR1 are briefly reviewed and the data structures discussed. The system architecture, based on Virtual Observatory standards, is also presented, together with the extensions that allow e.g. authenticated access, persistent uploads and table sharing. Finally some usage examples are provided.
Suppressing IL-36-driven inflammation using peptide pseudosubstrates for neutrophil proteases
Authors: Sullivan Graeme P. , Henry Conor M. , Clancy Danielle M. , Mametnabiev Tazhir , Belotcerkovskaya Ekaterina , Davidovich Pavel , Sura-Trueba Sylvia , Garabadzhiu Alexander V. , Martin Seamus J. 
Published: March 2018

AbstractSterile inflammation is initiated by molecules released from necrotic cells, called damage-associated molecular patterns (DAMPs). Members of the extended IL-1 cytokine family are important DAMPs, are typically only released through necrosis, and require limited proteolytic processing for activation. The IL-1 family cytokines, IL-36α, IL-36β, and IL-36γ, are expressed as inactive precursors and have been implicated as key initiators of psoriatic-type skin inflammation. We have recently found that IL-36 family cytokines are proteolytically processed and activated by the neutrophil granule-derived proteases, elastase, and cathepsin G. Inhibitors of IL-36 processing may therefore have utility as anti-inflammatory agents through suppressing activation of the latter cytokines. We have identified peptide-based pseudosubstrates for cathepsin G and elastase, based on optimal substrate cleavage motifs, which can antagonize activation of all three IL-36 family cytokines by the latter proteases. Human psoriatic skin plaques displayed elevated IL-36β processing activity that could be antagonized by peptide pseudosubstrates specific for cathepsin G. Thus, antagonists of neutrophil-derived proteases may have therapeutic potential for blocking activation of IL-36 family cytokines in inflammatory conditions such as psoriasis.
Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis
Authors: Ricciardiello Francesca , Votta Giuseppina , Palorini Roberta , Raccagni Isabella , Brunelli Laura , Paiotta Alice , Tinelli Francesca , D’Orazio Giuseppe , Valtorta Silvia , De Gioia Luca , Pastorelli Roberta , Moresco Rosa Maria , La Ferla Barbara , Chiaradonna Ferdinando 
Published: March 2018

AbstractCancer aberrant N- and O-linked protein glycosylation, frequently resulting from an augmented flux through the Hexosamine Biosynthetic Pathway (HBP), play different roles in tumor progression. However, the low specificity and toxicity of the existing HBP inhibitors prevented their use for cancer treatment. Here we report the preclinical evaluation of FR054, a novel inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect. In fact, FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival. In particular, in a model of Triple Negative Breast Cancer (TNBC) cells, MDA-MB-231, we show that these effects are correlated to FR054-dependent reduction of both N- and O-glycosylation level that cause also a strong reduction of cancer cell adhesion and migration. Moreover we show that impaired survival of cancer cells upon FR054 treatment is associated with the activation of the Unfolded Protein Response (UPR) and accumulation of intracellular ROS. Finally, we show that FR054 suppresses cancer growth in MDA-MB-231 xenograft mice, supporting the advantage of targeting HBP for therapeutic purpose and encouraging further investigation about the use of this small molecule as a promising compound for breast cancer therapy.