bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case–Control Study to Evaluate Serum Lipoprotein Levels and Other Biomarkers of Cardiovascular Disease in Patients With Psoriasis
Authors: Eleryan Misty G. , Akhiyat Sophia , Awosika Olabola , Wenk Kurt , Rengifo-Pardo Monica , Martin Lisa W. , Ehrlich Alison 
Published: July 2018

Background: Studies investigating lipid abnormalities associated with psoriasis have reported conflicting results. The purpose of this study is to evaluate differences in serum lipoprotein levels among patients with psoriasis compared to controls via the use of the Vertical Auto Profile (VAP) test, which directly measures the cholesterol concentrations of all 5 lipoprotein classes and their subclasses. We also assess other cardiovascular biomarkers, including highly sensitive C-reactive protein (hs-CRP), lipoprotein-associated phospholipase A2 (Lp-PLA2), and homocysteine. Methods: In this 6-year case–control study, 210 patients (110 patients with psoriasis and 100 controls) elected to participate in VAP testing between November 2009 and April 2016 at The George Washington Medical Faculty Associates dermatology clinic. All psoriatic cases were age-, sex-, and body mass index–matched to control patients. Data were analyzed in June 2016. We evaluated cardiovascular biomarkers in patients with psoriasis versus control patients and whether an association exists between the presence of psoriasis and the level of cardiovascular dysfunction. Results: Compared to the control group, patients with psoriasis had significantly lower high-density lipoprotein (HDL) ( P = .007), HDL2 ( P = .013), and HDL3 cholesterol ( P = .015) as well as higher low-density lipoprotein (LDL) pattern B ( P= .032), LDL3 ( P = .030), and LDL4 cholesterol ( P = .003). Patients with psoriasis also had lower apolipoprotein A1 ( P = .011), lower Lp-PLA2 ( P = .037), and higher hs-CRP ( P = .048). Conclusion: Our findings suggest an increased risk of cardiovascular biomarker dysfunction in patients with psoriasis compared to their matched controls. Serum biomarkers such as high LDL pattern B, LDL3, and LDL4 as well as lower HDL2, HDL3, and total HDL were found to have a higher association with psoriatic disease.
商代军事战略战术思想举隅
Authors: 王子杨  
Published: July 2018

摘要 关于商代的军事战略战术, 前人已有言及, 但比较零散。本文主要以甲骨卜辞为语料, 选取 “作战地点” 、 “作战路线” 、 “战略战术” 、 “伏击” 和 “攻城” 五个方面对殷代的军事战略战术进行了简单的论述, 希望对殷商史的研究有所助益。
In Vivo Deletion of β-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption
Authors: Hennings Thomas G , Chopra Deeksha G , DeLeon Elizabeth R , VanDeusen Halena R , Sesaki Hiromi , Merrins Matthew J , Ku Gregory M 
Published: July 2018

Abstract
Mitochondria are dynamic organelles that undergo frequent fission and fusion events. Mitochondrial fission is required for ATP production, the tricarboxylic acid cycle, and processes beyond metabolism in a cell-type specific manner. Ex vivo and cell line studies have demonstrated that Drp1, a central regulator of mitochondrial fission, is required for glucose-stimulated insulin secretion (GSIS) in pancreatic β cells. Herein, we set out to interrogate the role of Drp1 in β-cell insulin secretion in vivo. We generated β-cell–specific Drp1 knockout (KO) mice (Drp1β-KO) by crossing a conditional allele of Drp1 to Ins1cre mice, in which Cre recombinase replaces the coding region of the Ins1 gene. Drp1β-KO mice were glucose intolerant due to impaired GSIS but did not progress to fasting hyperglycemia as adults. Despite markedly abnormal mitochondrial morphology, Drp1β-KO islets exhibited normal oxygen consumption rates and an unchanged glucose threshold for intracellular calcium mobilization. Instead, the most profound consequences of β-cell Drp1 deletion were impaired second-phase insulin secretion and impaired glucose-stimulated amplification of insulin secretion. Our data establish Drp1 as an important regulator of insulin secretion in vivo and demonstrate a role for Drp1 in metabolic amplification and calcium handling without affecting oxygen consumption.
“Let’s Take a Leap”
Authors: Mourad Ghada 
Published: July 2018

AbstractThis article examines how the Moroccan Francophone writer Mohamed Leftah negotiates a decolonized modernity in his novel Le dernier combat du Captain Niʿmat (2011). This understanding of decolonization is based on Abdelkebir Khatibi’s pensée-autre, a mode of thinking that simultaneously embraces and disavows its constitutive traditions and attempts to formulate its own episteme. Living in Egypt, a queer diaspora for a Moroccan, Leftah employs queer male sexuality in a Sufialist text that tells the story of Niʿmat, an Egyptian retired army officer who pursues a love affair with his young Nubian servant, Islam. Transgressive sexuality, anachronistic gender typology, narrative modes, and historicizing onomastics decenter the metropole of France and articulate a decolonized modernity. Even as it centers male sexual unruliness and invites a queer reading, the text stabilizes other sexual and gender hierarchies, pointing to the need for texts revolving around queer feminist discourse in the Arab world.
Stage 2 Registered Report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: testing the double hit hypothesis
Authors: Newbury Dianne F. , Simpson Nuala H. , Thompson Paul A. , Bishop Dorothy V. M. 
Published: July 2018

Background: The presence of an extra sex chromosome is associated with an increased rate of neurodevelopmental difficulties involving language. The 'double hit' hypothesis proposes that the adverse impact of the extra sex chromosome is amplified when genes that are expressed from the sex chromosomes interact with autosomal variants that usually have only mild effects. We predicted that the impact of an additional sex chromosome on neurodevelopment would depend on common autosomal variants involved in synaptic functions. Methods: We analysed data from 130 children with sex chromosome trisomies (SCTs: 42 girls with trisomy X, 43 boys with Klinefelter syndrome, and 45 boys with XYY). Two comparison groups were formed from 370 children from a twin study. Three indicators of phenotype were: (i) Standard score on a test of nonword repetition; (ii). A language factor score derived from a test battery; (iii) A general scale of neurodevelopmental challenges based on all available information. Preselected regions of two genes, CNTNAP2 and NRXN1, were tested for association with neurodevelopmental outcomes using Generalised Structural Component Analysis. Results: There was wide phenotypic variation in the SCT group, as well as overall impairment on all three phenotypic measures. There was no association of phenotype with CNTNAP2 or NRXN1 variants in either the SCT group or the comparison groups. Supplementary analyses found no indication of any impact of trisomy type on the results, and exploratory analyses of individual SNPs confirmed the lack of association. Conclusions: We cannot rule out that a double hit may be implicated in the phenotypic variability in children with SCTs, but our analysis does not find any support for the idea that common variants in CNTNAP2 or NRXN1 are associated with the severity of language and neurodevelopmental impairments that often accompany an extra X or Y chromosome. Stage 1 report: http://dx.doi.org/10.12688/wellcomeopenres.13828.2
Matter Without Form: The Ontological Status of Christ's Dead Body
Authors: Jaeger Andrew J. , Sienkiewicz Jeremy 
Published: July 2018

In this paper, we provide an account of the ontological status of Christ’s dead body, which remained in the tomb during the three days after his crucifixion. Our account holds that Christ’s dead body – during the time between his death and resurrection – was prime matter without a substantial form. We defend this account by showing how it is metaphysically possible for prime matter to exist in actuality without substantial forms. Our argument turns on the truth of two theses: (i) God is able to produce all acts of secondary causes without those secondary causes, and (ii) Substantial forms are secondary causes of the actuality of prime matter. We argue that the metaphysical possibility of matter without form is perfectly consistent with holding both there is only one substantial form in a material substance and that prime matter is pure potentiality. Moreover, we argue that the metaphysical possibility of matter without form does little-to-no damage to our natural understanding of material substances.
Purgatory, Hypertime, and Temporal Experience
Authors: Rutledge Jonathan Curtis 
Published: July 2018

Recently, JT Turner has argued that proponents of temporally-extended models of purgatory (henceforth, temps) are committed to denying the doctrine of the parousia. Such persons typically argue that temporally-extended models of purgatory are needed to prevent the possibility that a morally imperfect human might become morally perfect too abruptly. In this article, I argue that Turner is mistaken and that by invoking hypertime and a clarification of the sort of abruptness at issue, temps can affirm both purgatory and the doctrine of the parousia.After clarifying the nature of hypertime, I then present a non-temporal model of purgatory. This model permits those uncomfortable with endorsing the metaphysical possibility of hypertime to nevertheless affirm the key intuition motivating temporally-extended models (i.e. that they are necessary to avoid too abrupt a change in character) without rejecting the doctrine of the parousia.
Peluang Keberlanjutan Program Penyediaan Air Minum Berbasis Komunitas (PAMSIMAS) di Kabupaten Kendal
Authors: Nugroho Ardhianto Adhi , Maryono Maryono 
Published: July 2018

Drinking Water Supply Program with Community-Based (PAMSIMAS) aims to halve the proportion of people who do not have access to drinking water and basic sanitation in Indonesia. One of the areas that became the location of the implementation of the Program Pamsimas is Kabupaten Kendal, with case study: Tanjungsari, Sidorejo, and Kalirandu Gede villages. To ensure the sustainability of the program, it is necessary to people's to understanding the implementation of the program and the factors of public concern to carry out the program. The purpose of this study was to determine the characteristics of sustainability Pamsimas in Kabupaten Kendal, in those three villages, which will be achieved by using one of the qualitative research approach, which is a case study (case study research). The qualitative analysis techniques used are for qualitative description analysis and comparative analysis. The result of this research can be concluded that those three villages are well understanding on the purpose of Pamsimas program. Each villages have valuables characteristics that can support the sustainability of the Pamsimas program. The factor of public awareness of the implementation of Pamsimas influenced by community and government relations, practical reasons as well as public awareness of the importance of protecting the environment.
Prediction of Difficult Tracheal Videolaryngoscopic Intubation Using El-Ganzouri Risk Index
Authors: Zakalkins Antons , Kazune Sigita 
Published: July 2018

Summary

Introduction. Unanticipated difficult intubation still exists as a significant problem. El-Ganzouri risk index is a bedside difficult airway evaluation method, which can help determine risk of difficult airways. However, evidence of using of El-Ganzouri risk index in difficult laryngeal visualisation using videolaryngoscopes is limited.

Aim of the Study. Determine the specificity and sensitivity of El-Ganzouri multivariate risk index to predict difficult laryngeal exposure using Storz C-MAC videolaryngoscope equipped with D type blade.

Material and methods. We conducted a study of 29 patients, which were examined using El-Ganzouri risk index before induction of anaesthesia. After induction of anaesthesia videolaryngoscopy was performed using Storz C-MAC videolaryngoscope equipped with D-blade and laryngeal visualisation was graded using Cormack-Lehane scale. After laryngeal visualisation grading endotracheal tube insertion was performed and numbers of attempts as well as complications during intubation were recorded. Sensitivity, specificity, positive and negative predictive values were calculated, receiver operating characteristic curve and area under curve was obtained.

Results. Sensitivity and specificity were 54.2% and 80.0% at El-Ganzouri risk index cut-off value of 2 points. Calculated positive predictive value was 26.7% and negative predictive value was 92.9%. Calculated AUC was 78.3%.

Conclusions. El-Ganzouri risk index shows moderate sensitivity and specificity when used with Storz C-MAC videolaryngoscope. It can be used to predict difficult laryngeal visualization during videolaryngoscopic intubation.
Who drove the discourse? News coverage and policy framing of immigrants and refugees in the 2016 U.S. presidential election
Authors: Ogan Christine , Pennington Rosemary , Venger Olesya , Metz Daniel 
Published: July 2018

Abstract
Migration was one of the most important issues in the 2016 U.S. presidential election. While Hillary Clinton promised an immigration reform that would create a path to citizenship, Donald Trump said he would deport illegal aliens, build a wall between the United States and Mexico, and suspend immigration from countries with a history of terrorism, capitalizing on some of the public’s fears through his rhetoric. We examine the ways mainstream national and regional press covered this issue from the Republican National Convention through Election Day. This content analysis of 12 news outlets finds that political themes drove the coverage more than anything else, with Donald Trump or a member of his team most often serving as theme sponsor. Though about half of the stories were neutral or balanced in tone, negative stories were sponsored either by the Trump team or other actors.
A Comparative Quantitative Analysis of the Postnatal Changes in the Myocardium of the Left and Right Ventricles in Rats
Authors: Iliev Alexandar A. , Kotov Georgi N. , Landzhov Boycho V. , Jelev Lazar S. , Dimitrova Iva N. , Hinova-Palova Dimka V. 
Published: July 2018

Abstract
Background: The growth of the heart during the foetal and early postnatal development takes places mainly due to hyperplasia. The late postnatal development is characterised by cardiomyocytic hypertrophy in response to normal physiological mechanisms and increased load. To study the cell size most authors measure the diameter either directly or indirectly.
Aim: The aim of the present study was to make a comparative quantitative analysis of the postnatal changes observed in the left and right ventricles in rat by evaluating the changes in three morphometric parameters – thickness of the free wall, transverse section of the cardiomyocytes and cardiomyocytic density in the left ventricle and right ventricle.
Materials and methods: In the present study, we used histological material from the hearts of 15 male Wistar rats, distributed in five groups aged 2 weeks, 1 month, 3 months, 6 months and 12 months, respectively.
Results: In both ventricles, the wall thickness and the transverse section of the cardiomyocytes increased with age, while the cardiomyocytic density decreased. Changes were identical in both ventricles; however, they were more dynamic and pronounced in the left ventricle.
Conclusions: The studied morphometric parameters reveal that age-related hypertrophy and the gradual loss of cardiac muscle cells take place in both ventricles but have a more dynamic pattern of progression in the left ventricle as compared with the right ventricle.
Analgesic Effect of Local Infiltration of the Surgical Wound Containing Levobupivacaine, Ibuprofen, and Epinephrine in Rats Undergoing Laparotomy
Authors: Korat Prashant S. , Kapupara Pankaj 
Published: July 2018

Abstract
Background: Inappropriate use of drugs and their combinations for analgesics has made it difficult to determine the optimal drug combinations for pain mangement.
Aim: To reduce postoperative pain effectively and safely.
Materials and methods: Laparotomy was performed in an adult rat under isoflurane anesthesia. During surgery, the surgical wounds were infiltrated with 50 μL solution containing 0.3% w/v levobupivacaine, 2 mg/mL ibuprofen, and 8 mg/mL epinephrine (treatment group) over the sutured muscle wound before skin closing, and compared to infiltration of that of the normal saline (vehicle group). The 10-fold higher dose of the same combination of medications was injected systemically as a control. Postoperative pain assessed by rodent grimace scales scoring. One-way ANOVA following Dunnett multiple comparisons test was used at 95% of confidence level.
Results: There was decreased pain for the treatment group (p = 0.025, q = 4.527) and the control group (p = 0.031, q = 4.178) only 24 h after the end of the successful infiltration. The rodent GS scale scoring showed the fall in pain was started within three hours post-surgery in the treatment group. There was decreased pain in the treatment group (p = 0.048, q = 3.527) and the control group (p = 0.043, q = 3.891) only as compared to vehicle group 24 h after the end of the successful infiltration.
Conclusion: The infiltration of the surgical wound with levobupivacaine, ibuprofen, and epinephrine combination was effective in the healing of wounds after laparotomy.
Clinical Assessment of Endodontically Treated Teeth, Restored with or without Radicular Posts
Authors: Karteva Ekaterina G. , Manchorova Neshka A. , Vladimirov Stoyan B. , Keskinova Donka A. 
Published: July 2018

Abstract
Background: The reduced fracture resistance in endodontically treated teeth requires the use of radicular posts, with their advantages and disadvantages.
Aim: To evaluate the clinical performance of teeth restored with or without radicular posts at 6 and 12 months.
Materials and methods: The study included 22 patients who received endodontic therapy on premolars with a loss of one or two proximal walls. The premolars were divided into groups according to the restoration method: metal post group (MP), fiber post group (FP), and no post group (NP). For the NP group, a dentinal core of fiber-reinforced composite was used. The McNemar test, marginal homogeneity test and Kruskal-Wallis test were used in the statistical analysis. At the 6 and 12 month recall, both the direct composite restorations and the integrity of the post systems were assessed.
Results: At 6-month recall assessment, there was no statistically significant difference in the categories of ‘appropriate colour’, ‘secondary caries’ and ‘obturation integrity’. That was not the case with ‘marginal discoloration’, ‘marginal adaptation’, ‘proximal contact’ and ‘surface smoothness’. The recall at 12 months showed a continuation of this tendency, with significant decrease in the category of ‘adequate colour’. Assessment of post longevity at the two recalls did not show any significant changes. The teeth restored without a post showed survival rates comparable to that of teeth restored with a post for the 12-month period of observation.
Conclusions: There were no failures of the different posts used. The observed changes were attributed to the progressive deterioration of the composite restorations.
Effect of yoga and naturopathy on liver, renal and cardiorespiratory functions of a patient with hepatic cirrhosis with portal hypertension and ascites: a case report
Authors: Revadi Shreya S. , Kavitha V. , Mooventhan A. 
Published: July 2018

Abstract
A 39-year-old, married man was diagnosed with hepatic cirrhosis with portal hypertension and ascites in February 2016. His symptoms as described by him began with generalized body weakness, breathlessness and sudden weight gain of 16 kg within 3 weeks. History of regular intake of alcohol since 7 years and tremendous family stress were present. Patient underwent conventional medication for 6 months and ayurvedic medications for 4 months. In January 2017, he visited our hospital with the same complaints and underwent integrated naturopathy and yoga therapies (INYTs) for 4 weeks along with Ayurveda and conventional medications. The results of this study showed a better reduction in body weight, body mass index, abdominal girth, systolic blood pressure and diastolic blood pressure along with improvement in breath holding time, hemoglobin level, liver function test and renal function test. It suggests that 4 weeks of INYT with Ayurveda and conventional medications was effective in patients with hepatic cirrhosis with portal hypertension and ascites. Further studies are required to warrant these results.
[Aristot.] Ath. Pol. 39.4: Wer durfte im oligarchischen Eleusis wohnen (403 v. Chr.)?
Authors: Tsakmakis Antonis 
Published: July 2018

ZusammenfassungDie parallele Untersuchung der historischen Quellen zum oligarchischen Teilstaat von Eleusis nach dem Sturz der Dreißig legt nahe, dass der Vertrag unter anderem die Ordnung in Eigentumsfragen wiederherstellen sollte, nachdem die Häuser der zuvor ermordeten Eleusinier von Athenern willkürlich in Besitz genommen worden waren. Während bisherige Interpretationen der entsprechenden Klausel von der Annahme ausgehen, dass viele Eleusiner gezwungen waren, ihre Häuser zu verlassen, wird argumentiert, dass sie das Recht behielten, weiter in Eleusis zu wohnen. Das eingeführte Vermittlungsverfahren wird als ein Indiz interpretiert, dass auch diese Maßnahme als Verhandlung mit dem Ziel der Versöhnung eingeführt wurde.
The Authenticity of the Document at Demosth. or. 24.20–3, the Procedures ofnomothesiaand the so-called ἐπιχɛιροτονία τῶν νόμων
Authors: Canevaro Mirko 
Published: July 2018

SummaryThis article is a response to Hansen's recent defence of the authenticity of the document at Demosth. or. 24.20–3. It discusses the methodology for assessing the authenticity of the documents in the orators, in particular the role(s) of the stichometry and the importance of the epigraphic evidence. It provides an in-depth analysis of the evidence about thenomothesiaprocedure provided in Demosthenes' „Against Timocrates“, showing, first, that this procedure was one centred on the enactment of new laws, and not, as the document describes, a general review of the laws of Athens; second, that the procedure described in the speech is one that can be initiated at all points of the year (consistently with what the epigraphic evidence shows), whereas the document describes an annual procedure taking place only on the 11thday of the first prytany; third, that the procedure described in the speech was initiated by a simple διαχειροτονία that allowed new proposals to be made, whereas the document describes multiple initial votes „kapitelweise“ to be held in the Assembly on different groups of existing laws. The last part of the article surveys eight specific problems with the text of the document, which confirm that it cannot be an authentic Athenian law.
‚200 Jahre Phylenreform des Kleisthenes‘ – die Neuorganisation von Athen und Attika (307/06 v. Chr.). Kontext, Umsetzung und Folgen
Authors: Weber Gregor 
Published: July 2018

ZusammenfassungDer Beitrag behandelt die Phylenreform von 307/06 v. Chr. in Athen und Attika, die durch die Einführung von zwei neuen Phylen, Antigonis und Demetrias, veranlasst wurde, so dass es fortan zwölf Phylen gab. Dies zog die Neuverteilung etlicher Demen nach sich. Gefragt wird zum einen nach dem konkreten administrativen Ablauf dieser Umstellung, zum anderen nach einem möglichen Muster hinter der Zuweisung der Demen an die neuen Phylen bzw. der damit verbundenen Rolle topographischer und prosopographischer Faktoren. Zudem ist von Interesse, worin die Folgen aus der Umstrukturierung, etwa für das Monument der Phylenheroen oder für die Verwaltungspraxis, bestanden und warum das neue System so lang Bestand hatte. Von der Umstellung vom Dezimal- auf das Duodezimalsystem waren in jedem Fall alle Bürger betroffen; ein Vorteil der Reform dürfte auch darin bestanden haben, Korrekturen innerhalb der Demenverteilung mit Blick auf die Bouleutenzahl anbringen zu können. Die neue Untergliederung spricht dafür, dass trotz einer nachlassenden inschriftlichen Praxis von einem Niedergang der Demen und Phylen seit dem ausgehenden 4. Jh. keine Rede sein kann.