bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PENDAPATAN BUNGA TERHADAP PROFITABILITAS PADA PT. BANK JABAR BANTEN
Authors: Mulyani Heni 
Published: March 2019

Penelitian ini mengkaji fenomena kinerja profitabilitas (ROA) pada PT. Bank Jabar Banten. Salah satu faktor yang mempengaruhi profitabilitas adalah pendapatan bunga. Pendapatan bunga merupakan pendapatan terbesar yang diterima bank dari kegiatan operasionalnya. Penelitian ini bertujuan untuk mengetahui pengaruh pendapatan bunga terhadap profitabilitas pada PT. Bank Jabar Banten. Penelitian ini menggunakan metode deskriptif verifikatif. Sumber data yang digunakan berupa data laporan keuangan publikasi triwulan PT. Bank Jabar Banten periode Maret 2003 sampai dengan Desember 2010 yaitu neraca dan laporan laba/rugi yang merupakan data sekunder. Untuk menganalisis data penelitian, digunakan regresi linier sederhana. Berdasarkan hasil analisis regresi linier sederhana diperoleh persamaan Ŷ = 0,91 + 1,10X, dari persamaan tersebut dapat disimpulkan bahwa pendapatan bunga mempunyai pengaruh positif terhadap profitabilitas, dimana setiap kenaikan pendapatan bunga akan mengakibatkan kenaikan profitabilitas (ROA) sebesar 1,10 kali, sebaliknya apabila terjadi penurunan pendapatan bunga maka akan mengakibatkan penurunan profitabilitas (ROA) sebesar 1,10 kali. Kata Kunci: Pendapatan bunga, profitabilitas bank
PENGARUH MANAJEMEN PERSEDIAAN DAN MANAJEMEN PIUTANG TERHADAP MODAL KERJA PERUSAHAAN (STUDI KASUS PADA PERUSAHAAN MANUFAKTUR SEKTOR INDUSTRI BARANG KONSUMSI YANG TERDAFTAR DI BEI)
Authors: Azizah Siti Wily 
Published: March 2019

Penelitian ini bertujuan untuk mengetahui pengaruh manajemen persediaan dengan indikator perputaran persediaan (ITO) dan manajemen piutang dengan indikator perputaran piutang (RTO) terhadap modal kerja perusahaan. Objek pada penelitian ini adalah perusahaan manufaktur sektor industri barang konsumsi yang terdaftar di BEI selama 5 tahun dengan total 100 data observasi. Metode penelitian yang digunakan adalah metode deskriptif dan verifikatif. Adapun teknik pengumpulan data yang digunakan adalah studi dokumentasi terhadap laporan neraca dan laporan laba rugi perusahaan manufaktur sektor industri barang konsumsi yang terdaftar di BEI. Analisis statistik yang digunakan dalam penelitian ini adalah teknik analisis regresi linier berganda untuk data panel dengan bantuan aplikasi EViews 8. Berdasarkan pengujian diperoleh hasil bahwa secara simultan manajemen persediaan dan manajemen piutang berpengaruh negatif terhadap modal kerja perusahaan. Secara parsial, manajemen persediaan berpengaruh negatif signifikan terhadap modal kerja perusahaan, sedangkan manajemen piutang berpengaruh negatif tidak signifikan terhadap modal kerja perusahaan. Kata kunci : Manajemen persediaan, manajemen piutang, modal kerja perusahaan, perputaran persediaan, perputaran piutang.
NÚMERO DE FOLHAS E BOKASHI NA BROTAÇÃO E CUSTOS DE PRODUÇÃO DE MUDAS DE Schinus terebinthifolius Raddi. POR ESTAQUIA
Authors: Santos Cleberton Correia , Leite Luiz Felipe Balbueno , Silva Orivaldo Benedito da , Torales Elissandra Pacito , Heredia Zárate Néstor Antonio , Vieira Maria do Carmo 
Published: March 2019

Schinus terebinthifolius Raddi. (pimenteira rosa, Anacardiaceae) é utilizada devido às suas propriedades medicinais e condimentares, com valor agregado no mercado. Apesar disso, há poucos estudos relacionados à propagação vegetativa e custos de produção de mudas da espécie. O objetivo deste trabalho foi avaliar a presença de folhas e uso de bokashi na propagação vegetativa da pimenteira rosa. Avaliaram-se três tipos de estacas caulinares com 0, 1 ou 2 folhas, sem e com adição de bokashi (10 g kg-1) ao substrato, sob sombrite 50%. O arranjo experimental foi em esquema fatorial 3x2, no delineamento de blocos casualizados, com quatro repetições. As maiores porcentagens de brotações foram observadas em estacas sem folhas, sem bokashi (50,0%), aos 35 e 42 dias após o estaqueamento (49,3% e 47,2%, respectivamente); o maior índice de velocidade de brotação foi nas estacas sem folhas (0,5766) e o maior comprimento de brotos (24,37 cm) foi observado com a adição de bokashi ao substrato. Os custos de produção variaram entre R$ 232,07, entre o maior (R$ 2.428,66) com bokashi e o menor (R$ 2.196,59), sem bokashi. A quantidade de folhas e uso de bokashi influenciaram na propagação por estaquia e custos na produção de mudas de pimenteira rosa.
Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs)
Authors: Ratajczak Weronika , Rył Aleksandra , Mizerski Arnold , Walczakiewicz Kinga , Sipak Olimpia , Laszczyńska Maria 
Published: March 2019

Intestinal microbiota is an element of the bacterial ecosystem in all mammalian organisms. These microorganisms play a very important part in the development, functioning, and modulation of the immune system from the moment of birth. In recent years, owing to the use of modern sequencing techniques, the microbiome composition in healthy people has been identified based on bacterial 16S rRNA analysis. Currently, more and more attention is being given to the influence of microorganisms on the host’s cellular metabolism. Analysis of microbial metabolites, among them short-chain fatty acids (SCFAs), and disruption of intestinal microbiota homeostasis in terms of their effects on molecular regulatory mechanisms of immune reactions will surely improve the understanding of the etiology of many common diseases. SCFAs, mainly butyrate, propionate, and acetate, occur in specific amounts, and their proportions can change, depending on the diet, age and diseases. The levels of SCFAs are substantially influenced by the ratio of commensal intestinal bacteria, the disturbance of which (dysbiosis) can lead to a disproportion between the SCFAs produced. SCFAs are regarded as mediators in the communication between the intestinal microbiome and the immune system. The signal they produce is transferred, among others, in immune cells via free fatty acid receptors (FFARs), which belong to the family of G protein-coupled receptors (GPCRs). It has been also confirmed that SCFAs inhibit the activity of histone deacetylase (HDAC) – an enzyme involved in post-translational modifications, namely the process of deacetylation and, what is new, the process of histone crotonylation. These properties of SCFAs have an effect on their immunomodulatory potential i.e. maintaining the anti/pro-inflammatory balance. SCFAs act not only locally in the intestines colonized by commensal bacteria, but also influence the intestinal immune cells, and modulate immune response by multi-protein inflammasome complexes. SCFAs have been confirmed to contribute to the maintenance of the immune homeostasis of the urinary system (kidneys), respiratory system (lungs), central nervous system, and the sight organ.
Effects of Benzo(a)pyrene on the endometrial receptivity and embryo implantation in mice: An experimental study
Authors: Mardanshahi Zeinab , Karimpour Abbasali , Talebpour Amiri Fereshteh , Valadan Reza 
Published: March 2019

Background: Benzo(a)pyrene (BaP) as an environmental pollutant is ubiquitous in the environment and it has destructive effects on human health. So far, various studies have demonstrated that BaP can cause adverse effects on the female reproductive system, but the existing information is limited about the effects of BaP on the endometrial receptivity and embryo implantation.
Objective: The aim of this study was to investigate the effects of BaP on the endometrial receptivity and implantation in mice.
Materials and Methods: In this experimental study, 40 pregnant BALB/c mice were divided into 5 groups (n = 8/each) as follows: experimental groups received the doses of 100 μg/kg, 200 μg/kg, and 500 μg/kg BaP dissolved in corn oil, the control group received normal saline and sham group received corn oil. Pregnant mice administered these solutions from Day 1 to Day 5 of gestation by gavage. On Day 6, the mice were sacrificed. Then their embryos were counted and the hormonal, histomorphological and molecular analyses were performed on themocusa of uterine tube.
Results: The data revealed that BaP reduces estrogen and progesterone levels, decreases the number of implantation site, endometrium thickness, uterine lumen diameter, stromal cells and endometrial glands, and blood vessels in the endometrium. However, the expression of Activin receptor-like kinase 5 and E cadherin genes was not changed by BaP with different doses.
Conclusion: The finding of this study showed that BaP can change estrogen and progesterone levels, and endometrial morphology leads to impairing the endometrial receptivity and decreasing the number of implantation site.
Key words: Benzo(a)pyrene, Embryo implantation, Estrogen, Progesterone, ALK5, E-cadherin.
Sexual and reproductive healthcare needs of Iranian men: A cross-sectional study
Authors: Javadnoori Mojgan , Hajizadeh Marjan , Javadifar Nahid , Hossein Haghighizadeh Mohammad 
Published: March 2019

Background: The sexual and reproductive health (SRH) needs of men have received little attention in Iran’s healthcare system. Developing appropriate strategies to meet men’s needs requires careful assessment and recognition of their health needs.
Objective: The objective of this study is to assess men’s SRH needs and satisfaction with received services.
Materials and Methods: This descriptive cross-sectional study was conducted with 1068 adult men aged between 20 and 60 years in Ahvaz in 2014. For obtaining the SRH services needs of men, in addition to the self-reported felt needs, expressed needs and unmet needs, a need assessment was also done using a questionnaire that was developed for the research; its validity and reliability were assessed.
Results: The men’s perceived, expressed and unmet needs for SRH services were, priority-wise, screening and diagnosis of male genital cancers (63.3%), receiving contraceptive methods (36%), diagnosis, and treatment of male sexual dysfunction (86.9%), respectively. Preventing sexually transmitted disease/AIDS (72.1%), using contraceptives correctly (39.5%), and resisting peer pressure (86.6%) were, respectively, the first felt, expressed, and unmet skills men needed. The results of multivariate logistical regression showed that there was a significant statistical correlation between men’s SRH needs and their socio-demographic factors (age, marital/educational status, income) (p < 0.05).
Key words: Reproductive health, Needs assessment, Men.
Europa, vía pedagógica: la viabilidad del Humanismo en época postmoderna
Authors: Vilanou Torrano Conrad 
Published: March 2019

En este artículo se presenta Europa como una historia narrada que ha recurrido a la pedagogía para transmitir sus valores. Desde esta perspectiva, Europa constituye un proyecto que se enraíza en la cultura clásica y que, a través del cristianismo, ha llegado a la modernidad gracias a los ideales de formación. Asimismo, se constata que la idea de Europa —entendida como un sistema axiológico— ha seguido un devenir dialéctico, de modo que a épocas en que han prevalecido los principios humanistas han seguido etapas en que han dominado los intereses económicos. Con la llegada de la crisis de 2008, parece que los valores humanistas que han dado sentido a la historia de Europa han quedado afectados, de modo que conviene garantizar la viabilidad del humanismo —esto es, la defensa de la dignidad humana— como un valor prioritario, a pesar de las incertidumbres que acechan al proyecto europeo en un mundo postmoderno.Recibido: 02 julio 2018 Aceptado: 06 septiembre 2018 Publicación en línea: 27 febrero 2019
El Derecho Comunitario de los contratos públicos: un pilar infravalorado de la superación de los nacionalismos y de construcción de la identidad europea
Authors: Gosálbez Pequeño Humberto 
Published: March 2019

Desde la adhesión de España a las Comunidades Europeas en 1986, la legislación española de contratos públicos acepta el principio de no discriminación por la nacionalidad, abandonando el proteccionismo nacional de los contratistas presente en la legislación española. La Ley 9/2017 de Contratos del Sector Público consolida ese proceso histórico de adaptación de la legislación española de contratos públicos. En el Derecho europeo de los contratos públicos aparece una identidad europea, una «nacionalidad europea» de los contratistas nacionales de los Estados miembros.Recibido: 02 julio 2018 Aceptado: 16 julio 2018 Publicación en línea: 27 febrero 2019
¿Identidad europea o identidades europeas?
Authors: José i Mestre Carles 
Published: March 2019

Nos ocuparemos del significado del término «identidad» desde una perspectiva filosófica concernida singularmente con lo político. Así pues, se tratará principalmente de determinar en qué sentido cabe hablar de una identidad política europea, y para ello se esclarecerá en primer lugar lo que signifique la expresión «identidad política». Se defenderá que una identidad política remite por defecto a lo colectivo, y que los límites de una colectividad política específica vienen definidos por un proceso de identificación recíproca entre individuos en relación con hechos típicamente históricos: respeto de un pasado (no necesariamente común), relación cultural en un presente (necesariamente, pues, compartido), y proyección hacia un futuro (a partir de un compromiso individual). Desde este análisis, se expondrá hasta qué punto es pertinente hablar de «identidad europea», y a partir de qué punto conviene más referirnos a «identidades europeas» a partir de la noción de «pueblo», todo ello sin dejar de prestar atención a la cuestión de la forma política.Recibido: 02 julio 2018 Aceptado: 16 julio 2018 Publicación en línea: 27 febrero 2019
Pelaksanaan Pendidikan Agama pada Sekolah-Sekolah di Kodia Malang
Authors: Kasiram Moh. 
Published: March 2019

Religious education is one of the more important elements in achieving the goal of national education in Indonesia. UUSPN No. 21 1989 and GBHN 1993 stated that religious education is compulsary for student in every level. This study tries to find out the implmentation of religious education in Malang city. It is found out that (1) religious teachers are very serious in preparing the lesson; (2) the teachers use new methods in teaching religion i.e. experiments and problem solving; (3) the quality of teacher achievement again is very good in preparing teaching plans and implementing PBM in the classroom; (4) all schools are conducive to religious education, because all principals are the main supporters in religious activities in schools; and (5) the limitations of facilities, infrastructure and funds are the main obstacles.
The Strategy of Spiritual Leadership
Authors: Jufrizen Jufrizen , Sari Maya , Nasutian Muhammad İrfan , Radiman Radiman , Wahyuni Sri Fitri 
Published: March 2019

To analyze the influence of spiritual leadership on the organizational commitment of lecturers, spiritual leadership on the workplace spirituality, spiritual leadership on spiritual survival, Workplace Spirituality on the organizational commitment of lecturers, and Spiritual Survival towards the organizational commitment of lecturers in Private Universities in Medan. The study population was all permanent lecturers of private universities owned by Foundation ( organizations) totaling 425 permanent lecturers who had functional positions as expert assistants, lecturers, and head lecturers and had the following characteristics: (1) tenure of over 1 year, (2 ) Domicile in Medan and (3) Carry out the Tri Dharma of Higher Education. Determination of the number using the Slovin formula and obtained as many as 219 lecturers and data analysis used was path analysis. The results showed that Spiritual Leadership had a positive and significant effect on the lecturers' organizational commitment, Spiritual Leadership had a positive and significant effect on workplace spirituality, Spiritual Leadership had a positive and significant effect on spiritual survival, Workplace Spirituality had a positive and significant influence on the organizational commitment of lecturers, and Spiritual Survival was influential positive and significant towards organizational commitment of lecturers at Private Universities in Medan City. In this study Workplace Spirituality and spiritual survival act as mediators
A Mathematical Model for Predicting Long-Term Productivity of Modern Multifractured Shale-Gas/Oil Wells
Authors: Li Gao , Guo Boyun , Li Jun , Wang Ming 
Published: March 2019

SummaryModern multifractured shale-gas/oil wells are horizontal wells completed with simultaneous-fracturing, zipper-fracturing, and (in particular) modified-zipper-fracturing techniques. An analytical model was developed in this study for predicting the long-term productivity of these wells under conditions of pseudosteady-state (PSSS) flow, considering the cross-bilinear flow in the rock matrix and hydraulic fractures. Performance of the model was verified with the well-productivity data obtained from a shale-gas well and a shale-oil well. Sensitivity analyses were performed to identify key parameters of hydraulic fracturing affecting well productivity. The conducted field case studies show that the analytical model overpredicts shale-gas-well productivity by 2.3% and underpredicts shale-oil productivity by 7.4%. A sensitivity analysis with the model indicates that well productivity increases with reduced fracture spacing, increased fracture length, and increased fracture width, but not proportionally. Whenever operational restrictions permit, more fractures with high density should be created in the hydraulic-fracturing process to maximize well productivity. The benefit of increasing fracture width should diminish as the fracture width becomes large. Increasing fracture length by pumping more fracturing fluid can increase well-production rate nearly proportionally. Therefore, it is desirable to create long fractures by pumping high volumes of fracturing fluid in the hydraulic-fracturing process.
ANGPTL3 Mutations in Unrelated Chinese Han Patients with Familial Hypercholesterolemia
Authors: Yang Yunyun , Yang Song , Jiao Xiaolu , Li Juan , Zhu Miaomiao , Wang Luya , Qin Yanwen 
Published: March 2019

Background and objective:
Familial hypercholesterolemia (FH) is a severe genetic hyperlipidemia
characterized by increased levels of low-density lipoprotein cholesterol (LDL-C), leading to premature atherosclerosis.
Angiopoietin-like protein (ANGPTL3) is a hepatocyte-specific protein that can be used to lower LDL in
FH. However, it was unknown whether ANGPTL3 variants are present in FH patients. This study was performed
to identify ANGPTL3 variants in unrelated Chinese Han patients with FH.

Methods and Results:
We screened 80 patients with FH (total cholesterol >7.8mmol/L, LDL-cholesterol
>4.9mmol/L) and 77 controls using targeted next-generation sequencing (NGS) of six FH candidate genes
(LDLR, ApoB100, PCSK9, ABCG5, ABCG8, and ANGPTL3). Candidate pathogenic variants identified by NGS
were validated by Sanger sequencing. Mutant and wild-type plasmids containing the variant sequence were constructed
and verified by Sanger sequencing. The gene expression profile was analyzed by an expression profile
chip in transfected HepG2 cells using quantitative real-time (qRT)-PCR. We identified 41 variants in 28 FH patients,
including two ANGPTL3 mutations: one exonic (c.A956G: p.K319R) and one in the untranslated region
(c.*249G>A). Gene ontology analyses found that the cholesterol metabolic process and ANGPTL3 expression
were significantly up-regulated in the ANGPTL3 K319R mutation group compared with the wild-type group.
qRT-PCR findings were consistent with the expression profile analysis.

Conclusion:
Rare ANGPTL3 variants were identified in Chinese patients with FH, including ANGPTL3:
p.(Lys319Arg) which affected the expression of ANGPTL3 and the cholesterol metabolic process as determined
by bioinformatics analysis.

:
Clinical Trial Registration: Chinese Clinical Trial Registration (ChiCTR-ROC-17011027)
http://www.chictr.org.cn/listbycreater.aspx
Dehydroabietylamine, A Diterpene from Carthamus tinctorious L. Showing Antibacterial and Anthelmintic Effects with Computational Evidence
Authors: SJ Aditya R. , CK Ramesh , S Raghavendra , M Paramesha 
Published: March 2019

Background:Plant-based drugs provide an outstanding contribution to modern therapeutics, and it is well known that the presence of different phytochemicals is responsible for such pharmacological effects. Carthamus tinctorius L. is one such medicinally important plant whose different solvent extracts have been reported with several pharmacological effects like antibacterial, hepatoprotective, and wound healing. The exploration of phytoconstituents from such a medicinally important plant for different pharmacological effects could produce new and effective drugs to treat human diseases.Objective:The present study attempts to explore the antibacterial and anthelmintic properties of dehydroabietylamine, a diterpene isolated from Carthamus tinctorius L. followed by the in silico elucidation of its probable mode of action.Methods:The minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) of dehydroabietylamine were assessed against Staphylococcus aureus and Pseudomonas aeruginosa, using micro- broth dilution method. The anthelmintic activity of was determined to assess the time taken for paralysis and death of Pheretima Posthuma at different concentrations. Additionally, molecular docking study was conducted to understand the interaction between dehydroabietylamine with target proteins identified for both antibacterial and anthelmintic activity viz., glucosamine-6-phosphate synthase and β-Tubulin, respectively.Results:The dehydroabietylamine showed the significant MIC for S. aureus (12.5 μg/ml) and P. aeruginosa (6.25μg/ml), respectively. The result of anthelmintics effect of dehydroabietylamine was found to be dosedependent and compared to the standard drug, albendazole.Conclusion:The interactions of dehydroabietylamine with the two target proteins with high binding affinity indicated the probable inhibition of target proteins, which could be the cause for prominent antibacterial and antihelminthic effects.
Microsomal Prostaglandin E2 Synthase-1 as a New Macromolecular Drug Target in the Prevention of Inflammation and Cancer
Authors: Bülbül Bahadır , Küçükgüzel İlkay 
Published: March 2019

Background:
Cancer is one of the most life-threatening diseases worldwide. Since inflammation is
considered to be one of the known characteristics of cancer, the activity of PGE2 has been paired with different
tumorigenic steps such as increased tumor cell proliferation, resistance to apoptosis, increased invasiveness,
angiogenesis and immunosuppression.

Objective:
It has been successfully demonstrated that inhibition of mPGES-1 prevented inflammation in preclinical
studies. However, despite the crucial roles of mPGEs-1 and PGE2 in tumorigenesis, there is not much in vivo study
on mPGES-1 inhibition in cancer therapy. The specificity of mPGEs-1 enzyme and its low expression level under
normal conditions makes it a promising drug target with a low risk of side effects.

Methods:
A comprehensive literature search was performed for writing this review. An updated view on PGE2
biosynthesis, PGES isoenzyme family and its pharmacology and the latest information about inhibitors of mPGES-1
have been discussed.

Results:
In this study, it was aimed to highlight the importance of mPGES-1 and its inhibition in inflammationrelated
cancer and other inflammatory conditions. Information about PGE2 biosynthesis, its role in inflammationrelated
pathologies were also provided. We kept the noncancer-related inflammatory part short and tried to bring
together promising molecules or scaffolds.

Conclusion:
The information provided in this review might be useful to researchers in designing novel and potent
mPGES-1 inhibitors for the treatment of cancer and inflammation.