bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and morphological characteristics of type 1 and 2 autoimmune pancreatitis
Authors: Lishchuk S. V. , Dubova Е. A. , Pavlov K. А. , Udalov Yu. D. 
Published: September 2018

Rationale: In the recent years, an increased interest to autoimmune pancreatitis (AIP) has been seen, related to growing diagnostic potential. In its turn, this leads to an increase in numbers of diagnosed AIP cases. At present, two types of AIP have been described with diverse clinical manifestation and morphology of the pancreas. However, the reproducibility of the differential diagnosis between AIP type 1 and 2 is low even among pancreatic pathologists.Aim: To identify criteria for the morphologic diagnosis of AIP type 1 and 2.Materials and methods: A morphological study of biopsy and surgical specimens from 26 patients with AIP was performed. There were 22 cases of AIP type 1 and 4 cases of AIP type 2. In addition to hematoxylin eosin staining of the specimens, immunohistochemistry was used with counting of CD138+ absolute numbers, determination of IgG+ and IgG4+ cells in the inflammatory infiltrates, as well as the ratios of IgG4+/IgG+ and IgG4+/CD138+ cells.Results: AIP type 1 was characterized by storiform fibrosis of the pancreatic tissue (81.8% cases), involving the parapancreatic fat tissue, by moderateto-severe lymphoplasmocytic infiltration and signs of obliterative/non-obliterative phlebitis. Type 2 AIP was characterized by severe fibrosis with predominantly periductal (centrilobular) fibrosis and mild chronic inflammatory infiltration of the pancreas, while there was no extension of fibrosis and inflammatory infiltration to the parapancreatic tissues in any case. The mean number of CD138+ cell in AIP type 1 was 101.2 ± 27.9 per 1 high-power field (HPF), and in AIP type 2, it was 42.8 ± 20.9 per 1 HPF. The mean absolute number of IgG+ cells in AIP type 1 was 99.6 ± 25.7 per 1 HPF, whereas in AIP type 2, 42.1 ± 20.8 per 1 HPF. In AIP type 1, the mean number of IgG4+ plasmatic cells in the infiltrates was 74.5 ± 27.2 per 1 HPF, whereas in AIP type 2, it was 3.4 ± 2.7 per 1 HPF. The IgG4+/IgG+ ratio was 75 ± 12.6% vs. 8.4 ± 6.2%, and the IgG4+/CD138+ ratio was 72.4 ± 12.3% vs. 8.3 ± 5.9% in AIP type 1 and type 2, respectively.Conclusion: For the differential diagnosis of type 1 and 2 AIP, it is necessary to take into consideration not only typical histological abnormalities, but also the numbers of CD138+, IgG+ and IgG4+ cells within the inflammatory infiltrate, as well as the IgG4+/IgG+ and IgG4+/CD138+ ratios.
Rare clinical cases of “combined” skin carcinomas in cadaver renal allograft recipients
Authors: Kazantseva I. A. , Gurevich L. E. , Bobrov M. А. 
Published: September 2018

The most prevalent skin cancer in the transplant organ recipients is squamous cell cancer, followed by basal cell cancer. The skin cancer incidence and related mortality in the transplant organ recipient are significantly higher than those in the general population, which is to be linked with prolonged pharmaceutical immunosuppression. Multiple tumors are also typical for this patient group. The article describes two rare combinations of skin carcinomas with different histological characteristics in patients with cadaver renal allograft (CRA). Clinical case 1: A 43-year old female patient. In 2011, she was transplanted with a CRA due to end-stage renal failure caused by congenital cystic dysplasia (multicystic kidney disease), with subsequent removal of the allograft at 1.5 months after the transplantation. In 2014, she had her second CRA transplanted and until now is on immunosuppressive therapy. In 2013, the patient noticed two slowly growing masses in her right and left supraclavicular areas; they were clinically assessed as basal cell cancer and surgically resected. Histological examination of the resected skin fragments showed squamous cell carcinoma focuses in situ (Bowen's disease), with alternating superficial basalioma focuses; proliferating keratinizing squamous cell cancer with polymorphous structure, with prevailing acantholytic type, morphoeic basal cell carcinoma and basal squamous cell carcinoma were found throughout the dermal layer, up to the subcutaneous tissue. Clinical case 2: A 63-year old male patient was transplanted with CRA in 2007, due to end-stage renal failure caused by nephrolithiasis and chronic pyelonephritis. During the examination performed in 2013, a mushroom-like tumor (with a 3 cm diameter and a stipe of 1 cm in diameter, with erythematous tuberous surface) was found on the anterior neck surface, near the suprasternal notch. The tumor was surgically resected within the normal skin. Histological and immunochemical examinations showed that the mass consisted of two different tumors closely adjacent one to the other and separated by a narrow dermal layer, namely, neuroendocrine Merkel cell skin carcinoma and porocarcinoma with some signs of squamous cell and sebaceous cell differentiation.Conclusion: The descriptions of the rare cases confirm that transplantation-related skin cancers are highly relevant. Due to continuous renewal of the tissue components that is intrinsic to this organ, and due to deterioration of the immune control over proliferation and differentiation, they are characterized by a multiplicity of histological types and an unfavorable prognosis.
Examining the Impact of Workplace Spirituality and Procedural Justice on Work Locus of Control, Employee Job Satisfaction, and Employee Organisational Commitment
Authors: Maziriri Eugine Tafadzwa , Mapuranga Miston , Madinga Nkosivile Welcome 
Published: September 2018

The present examination explored the impact of
work spirituality and procedural justice on work locus of control, worker work fulfillment and representative authoritative duty among workers from private establishments of high learning in South Africa. Due to limited researches that have concentrated on the impact of workplace spirituality and procedural justice on work locus of control, employee job satisfaction and employee organisational commitment in developing countries especially in Southern Africa. A review was done and information was accumulated by methods for surveys on a sample of 150 academics and support staff in a private university setting in Gauteng, South Africa. Structural equation modelling was employed to analyse data using the Smart Partial Least Squares (PLS) software. By means of a partial least squares structural equation modeling approach, this study validates that elements such as workplace spirituality, procedural justice and work locus of control are instrumental in stimulating the employee job satisfaction and employee job commitment. The present investigation offers suggestions for academicians in the field of resource management by upgrading their comprehension of the how workplace spirituality and procedural justice impacts work locus of control, employee job satisfaction and employee organisational commitment
Synthesis and Antifungal Activities of Drimane-Amide Derivatives from Sclareol
Authors: Ma Miaofeng , Feng Jili , Wang Dezhi , Chen Shu-Wei , Xu Hui 
Published: September 2018

Aim and Objective:
Plant diseases are caused by fungal pathogens lead to severe
economic losses in many agriculture crops. And the increasing resistance of many fungi to
commonly used antifungal agents necessitates the discovery and development of new fungicides. So
this study was focused on synthesizing novel skeleton compounds to effectively control plant
diseases.

Materials and Methods:
A series of drimane-amide derivatives were designed, synthesized by
aminolysis reaction of amine with intermediate sclareolide which was prepared from sclareol.
The structures of all the synthesized compounds were confirmed using 1H NMR, 13C NMR, and HRMS
(ESI) spectroscopic data. Their in vitro antifungal activity were preliminarily evaluated by using
the mycelium growth rate method against five phytopathogenic fungi: Botrytis cinerea,
Glomerella cingulata, Alternaria alternate, Alternaria brassicae, and Fusarium
graminearum.

Results:
23 target compounds were successfully obtained in yields of 52-95%. Compounds
A2 and A3 displayed favorable inhibitory potency against B. cinerea, G. cingulata and A.
brassicae with IC50 values ranging from 3.18 to 10.48 µg/mL. These two compounds
displayed higher fungicidal activity than sclareol against all the tested phytopathogenic fungi,
and were more effective than the positive control thiabendazole against A. alternate and A.
brassicae. The structure-activity relationship studies of compounds A1-10 indicated that both the
position and type of substituent on the phenyl ring had significant effects on antifungal activity.

Conclusion:
The drimane-amide derivatives A2 and A3 were the most promising derivatives
and should be selected as new templates for the potential antifungal agents.
Controlled Release of Doxycycline by Magnetized Microporous MIL53(Fe); Focus on Magnetization and Drug Loading
Authors: Naeimi Shakiba , Faghihian Hossein 
Published: September 2018

Background:
In this research, MIL-53(Fe) was magnetized and the performance of the magnetized
material as a drug delivery system for doxycycline was studied.

Objectives:
The experiments were designed to load the magnetic delivery compounds with different
amount of the drug.

Methods:
The in vitro release rate of doxycycline from magnetic MIL-53(Fe) with different drug content
into saline buffered fluid (SBF, pH=7.4) and phosphate buffered saline (PBS, pH=3) was then studied.

Results:
The results showed that the releasing process of the drug in PBS media achieved the equilibration
within 48h with 98% of releasing efficiency, while the releasing process in SBF media (pH=7.4)
was slower and the equilibrium was established within 264 h with the releasing efficiency of 95%. The
amount of the released doxycycline from the samples with different drug content was measured at
various time intervals.

Conclusion:
It was concluded that in PBS media after 75 h, 85, 95 and 98% of loaded doxycycline released,
respectively, from the sample containing 22, 32 and 35% of the drug. In SBF media, the release
was slower and after 350 h, 82, 91 and 95% of loaded doxycycline released from the samples, respectively,
containing 22, 32 and 35 % of the drug. The results of this study indicated that by use of drugreleasing
profile and selecting appropriate carrier dose, the released amount of the drug into the patient
body can be controlled.
A New Therapeutic Approach for Brain Delivery of Epigallocatechin Gallate: Development and Characterization Studies
Authors: Kaur Harjeet , Kumar Baldeep , Chakrabarti Amitava , Medhi Bikash , Modi Manish , Radotra Bishan Dass , Aggarwal Ritu , Sinha Vivek Ranjan 
Published: September 2018

Background:Blood-brain permeability is the primary concern when dealing with the biodistribution of drugs to the brain in neurological diseases.Objective:The purpose of the study is to develop the nanoformulation of Epigallocatechin gallate (EGCG) in order to improve its bioavailability and penetration into the brain.Methods:EGCG loaded Solid Lipid Nanoparticles (SLNs) have been developed using microemulsification method and pharmacological assessments were performed.Results:Surface morphology and micromeritics analysis showed the successful development of EGCG loaded solid lipid nanoparticles with an average size of 162.4 nm and spherical in shape. In vitro release studies indicated a consistent and slow drug release. Pharmacological evaluation of SLN-EGCG demonstrated a significant improvement in cerebral ischemia-induced memory impairment.Conclusion:The results indicate that the EGCG loaded SLNs provide a potential drug delivery system for improved delivery of EGCG to the brain, hence, enhancing its brain bioavailability.
Off-line Chinese Signature Verification Using Convolutional Neural Network
Authors: Hong Shao , Rongze Xu , Xiaopeng Guo , Wencheng Cui 
Published: September 2018

Background:
The unique individual biological characteristics is used for identification in
biometrics, which is safe and difficult to forge. Therefore, it can help to enhance the safety of access
control system. Since the developing of modern information science and technology, computerbased
signature verification system enables signature verification more efficiently and automatically
in comparison with traditional human identification method.

Methods:
In order to improve the accuracy of Chinese signature verification, an off-line Chinese signature
verification method based on deep convolutional neural network is proposed. First, the machine
learning library Tensorflow is build, and the volunteers are invited to establish the offline Chinese
signature dataset. Second, the dataset is pre-processed, including denoising, binarization and size
normalization. Finally, three different CNN architectures (AlexNet, GoogleNet, VGGNet) are adopted
to implement the signature verification.

Results:
Experimental results show that the performance of AlexNet is better than that of the other
two convolutional neural network architectures, the accuracy of classification has been up to 99.77%,
and verification rate is 87.5%.

Conclusion:
Compared with the traditional offline Chinese signature recognition method, the method
based on the convolutional neural network Alex Net-f is better than other methods to some extent,
and avoids the complicated feature engineering.
Flare-Up Phenomenon of Intradermal Test with Anaphylactic Reaction to Paracetamol (Acetaminophen)
Authors: Rodríguez-Fernández Ana , Sánchez-Domínguez Marcos , Noguerado-Mellado Blanca , Rojas-Pérez-Ezquerra Patricia 
Published: September 2018

Background:
Paracetamol is a Non-Steroidal Anti-Inflammatory Drug (NSAID) that can
produce hypersensitive reactions mediated by specific immunological mechanisms (IgE or T celldependent)
or by a non-immunological mechanism (inhibition of cyclooxygenase COX-1).

Objective:
An 80-year-old man with a history of allergy to pyrazolones, with good tolerance to other
NSAIDs was referred to our allergy department because he presented a generalized urticaria after the
administration of Intravenous (IV) paracetamol.

Methods:
We performed an Intradermal Test (IDT) with paracetamol (0.02mg/ml) and later a Single
Blind Oral Challenge Test (SBOCT) with oral paracetamol.

Results:
IDT reading at 15min showed negative result so an SBOCT was performed with oral
paracetamol. With an accumulative dose of 250mg, after 20min, he developed discomfort, nausea and
dizziness, urticarial, hypotension (BP 80/40) as well as flare-up phenomenon was observed in the site
of the IDT with paracetamol. Tryptase levels during the reaction and 2hrs later were increased.

Conclusions:
We present an anaphylactic shock due to sensitization to paracetamol because of a type I
hypersensitivity mechanism, diagnosed by SBOCT and a positive IDT because of flare-up phenomenon,
in a patient with previous pyrazolones allergy and with tolerance to other NSAIDs. Some relevant
patents are also summarized in this paper.
Financiarización y desarrollo económico en la República Dominicana
Authors: Calvo Rosalía 
Published: September 2018

<p>En las últimas décadas las estructuras productivas y financieras de la República Dominicana han presentado características similares a las que muestra la región.<br />En el ámbito del sistema financiero se observan similitudes, en sintonía con los procesos de financiarización experimentados, no obstante, con ciertos rasgos distintivos. El análisis de las implicaciones de este proceso constituye un aspecto clave para entender el desarrollo del país, así como para formular políticas económicas eficaces que permitan alcanzar niveles de crecimiento sostenible.</p>
Kedudukan Peraturan Mahkamah Agung Nomor 13 Tahun 2016 Dalam Mengatasi Kendala Penanggulangan Tindak Pidana Korporasi (The Role Of Regulation Of The Supreme Court Number 13 Year 2016 In Overcoming Obstacles Of Corporate Criminal Infringement)
Authors: Suhariyanto Budi 
Published: September 2018

The prevention of corporate crime in Indonesia is constrained due to unclear management of corporate crime. In order to overcome the imperfection of such arrangements, the Supreme Court issued Supreme Court Regulation No.13 of 2016 on the Procedures for Corruption Case Handling by Corporations. There are questions that arise, what are the obstacles faced by Law Enforcement in an effort to overcome corporate crime and how the role of Perma No. 13 of 2016 in overcoming the obstacles to overcome the criminal act of the corporation? Normative legal research method is used to answer the problem. Normatively, from various laws governing the corruption of the subject of crime, there is no detailed formulation of corporate handling procedures so that law enforcers experience difficulties in conducting the criminal proceedings against the corporation. Article 79 of the Law on the Supreme Court provides the legal basis that if there is a legal deficiency in the course of the judiciary in any case, the Supreme Court has the authority to enact legislation to fill such shortcomings or vacancies. Perma No.13 of 2016 can be used as a guide for Law Enforcement to overcome technical obstacles of corporation criminal procedure law. Nevertheless, Perma has limitation so that required update of corporation criminal procedure in RKUHAP. AbstrakPenanggulangan tindak pidana korporasi di Indonesia mengalami kendala akibat tidak jelasnya pengaturan penanganan tindak pidana korporasi. Dalam rangka mengatasi ketidaksempurnaan pengaturan tersebut, Mahkamah Agung menerbitkan Peraturan Mahkamah Agung No.13 Tahun 2016 tentang Tata Cara Penanganan Perkara Tindak Pidana Oleh Korporasi. Ada pertanyaan yang mengemuka yaitu apa saja kendala yang dihadapi Penegak Hukum dalam upaya menanggulangi tindak pidana korporasi dan bagaimana peran Perma Nomor 13 Tahun 2016 dalam mengatasi kendala penanggulangan tindak pidana korporasi tersebut? Metode penelitian hukum normatif digunakan untuk menjawab permasalahan tersebut. Secara normatif, dari berbagai peraturan perundang-undangan yang mengatur korporasi subjek tindak pidana, tidak dirumuskan detail tata cara penanganan korporasi sehingga penegak hukum mengalami kendala dalam melakukan proses pemidanaan terhadap korporasi. Pasal 79 Undang-Undang tentang Mahkamah Agung memberikan dasar hukum bahwa apabila dalam jalannya peradilan terdapat kekurangan atau kekosongan hukum dalam suatu hal, Mahkamah Agung memiliki wewenang membuat peraturan untuk mengisi kekurangan atau kekosongan tersebut. Perma No. 13 Tahun 2016 dapat dijadikan pedoman bagi Penegak Hukum untuk mengatasi kendala teknis hukum acara pidana korporasi. Namun, Perma tersebut memiliki keterbatasan sehingga diperlukan pembaruan hukum acara pidana korporasi dalam RKUHAP.
XYLITOL ON DENTAL CARIES: A REVIEW
Authors: Gupta Jatin , Gupta Kanupriya 
Published: September 2018

Xylitol is a pentahydroxy sugar-alcohol which exists in a very low quantity in fruits and vegetables (plums, strawberries, cauliflower, and pumpkin). On commercial scale, xylitol can be produced by chemical and biotechnological processes. Chemical production is costly and extensive in purification steps. The precursor xylose is produced from agricultural biomass by chemical and enzymatic hydrolysis and can be converted to xylitol primarily by yeast strain. Hydrolysis under acidic condition is the more commonly used practice influenced by various process parameters. Biotechnological xylitol production is an integral process of microbial species belonging to Candida genus which is influenced by various process parameters such as pH, temperature; time, nitrogen source, and yeast extract level. It is a functional sweetener as it has prebiotic effects which can reduce blood glucose, triglyceride, and cholesterol level. Dental caries is an infectious microbiologic disease of the tooth that results in localized dissolution and destruction of calcified tissues. Xylitol has been shown to reduce dental caries when mixed with food, chewing gums and milk. Dental caries are prevalent in acidic pH where Streptoccocus mutans (MS) ferment resulting in demineralization of tooth, where as Streptococcus mutans cannot ferment xylitol thus it reduces MS by altering their metabolic pathway and enhance remineralization and helps arrest dentinal caries. Reduction in caries rate is greater, when xylitol is used as the sugar substitutes. This review discusses the taste acceptability of xylitol in milk as a step towards measuring the effectiveness for the reduction of dental caries.
Keywords: Xylitol, Carbohydrates, Caries, Remineralisation, Demineralization, Streptoccocus mutans
THE PROTECTIVE EFFECTS OF AQUEOUS EXTRACT OF AFRICAN NUTMEG (Myristica fragrans) IN BROMATE-INDUCED SPLEEN AND CARDIAC TISSUE TOXICITIES USING MALE WISTAR ALBINO RATS
Authors: Oseni Oatunde Abass , Olagboye Sulaiman Adeoye , Adams Olusegun Timothy , Maikasuwa Bamaiyi Sunday 
Published: September 2018

This study was aimed at investigating the toxic effects of potassium bromate on the spleen and heart of Wistar albino rat and to evaluate the protective effects of aqueous extract of African nutmeg (Myristica fragrans) against potassium bromate induced toxicity in the two organs. Twenty-four (24) male wistar albino rats weighing between 180g and 200g were divided into four groups of six animals each. Group I animals were served with rat feed and water as the control group, group II were administered daily with 30mg/kg bw potassium bromate while groups III and IV animals were administered with 0.5mL of 20% and 40% aqueous extracts of nutmeg seed in addition with 30mg/kg body weight potassium bromate respectively for two weeks. The animals were kept at optimum temperature within a 12 hours light/dark cycle while the experiment lasted. Enzyme biomarkers such as Aspartate Transaminase, Alanine Transaminase, Alkaline Phosphatase; antioxidant enzymes such as, Superoxide dismutase, Catalase; reduced Glutathione; some lipid profiles like Cholesterol, Triglyceride and malondialdehyde were measured in the spleen and heart homogenates of the animals in all the groups. Results of this study showed that potassium bromate exerted significant (P < 0.05) toxic effects on the spleen and heart homogenates while the administration of aqueous extracts of African nutmeg seed caused a marked reversal in the toxicity in a dose dependent manner. However, the results of this study showed that aqueous extract of the seed of African nutmeg is a potential antioxidant against potassium bromate toxicity in the two organs.
Keywords: Toxicity, Potassium bromate, Myristica fragrans, Cardiac tissue, Antioxidant
ETHNOPHARMACOLOGICAL STUDIES OF Polypodium vulgare Linn. : A COMPREHENSIVE REVIEW
Authors: Khan Afshan , Siddiqui Aisha , Jafri M.A , Asif Mohd 
Published: September 2018

Polypodium vulgare Linn. commonly called as Bisfaij is a medicinal plant which is used in various ailments. It is one of the most archaic and essential plant, belonging to the family Polypodiaceae. It contains organic substances such as resin, tannins, steroids, flavonoids, alkaloids, glycosides, protein, reducing sugar and inorganic substances like calcium, magnesium, potassium, sulphur, iron and chloride. It is used in Unani system of medicine for the treatment of sorethroat, stomach-aches, leprosy, melancholia, spleenomegaly, haemorrhoids, rheumatic swelling of the joints etc. Besides this, it has other pharmacological activities too such as antiepileptic, neuro-psychopharmacological, antipyretic, antibiotic, antiviral etc. This review paper discuses the medicinal values of Polypodium vulgare Linn. in Unani medicine as well as its modern pharmacology and gives a new impetus to utilize Bisfaij in various disorders.
Keywords: Bisfaij, Polypodium vulgare Linn, Phytopharmacology, Unani Medicine.