bluuebunny/crossref_metadata_2025_split huggingface dataset:
Output force of giant magnetostrictive actuator
Authors: Wu Yan , Liu Xuhui , Guo Tiantian , Qiu Ye 
Published: September 2019

A new type of intelligent micro displacement materials, giant magnetostrictive materials (GMM), have a wide range of potential applications in the fields of micro vibrations. In this paper, a novel type of giant magnetostrictive actuator (GMA), mainly made by the giant magnetostrictive materials, is designed, and its inner structure and working principle are also discussed. To investigate the output force of giant magnetostrictive actuator, a test system, including the force sensor, data acquisition card and power supply equipment are established. The experimental results show, when the excited current increased from 0.5 A to 2 A gradually, the output force of the giant magnetostrictive actuator also gradually increased, in the condition of the pre-compress force from 100 N to 400 N, the output force of the giant magnetostrictive actuator will also increase with the increasing of the pre-compress force.
Potential for limited reinforcing and abuse-related subjective effects of intranasal oxytocin
Authors: Dolan Sean B , Berry Meredith S , Johnson Patrick S , Johnson Matthew W 
Published: September 2019

Background: There has been growing interest in using oxytocin as a pharmacotherapy for psychiatric disorders, including substance use disorder. Limited data exist regarding oxytocin’s reinforcing efficacy, which is a necessary consideration for novel pharmacotherapies, especially in substance-using populations. Aims: This study aimed to determine the potential reinforcing effects of intranasally administered oxytocin by assessing behavioral economic demand and subjective effects. Methods: Healthy adults ( n = 23) participated in a double-blind, repeated-measures, laboratory study wherein they received intranasal oxytocin (40 IU) or placebo in a randomized order across two sessions. Participants completed drug purchasing tasks at the conclusion of both sessions. Throughout both sessions, subjective and physiological effects were assessed. Results: Demand-curve analysis of purchasing tasks revealed greater median purchasing for oxytocin relative to placebo. Physiological and subjective effects did not significantly differ between oxytocin and placebo. However, a nonsignificant trend was observed for moderately greater drug liking for oxytocin relative to placebo. There was a significant, positive correlation between the difference in drug liking (between oxytocin and placebo) and the difference in lowest-price purchasing (between oxytocin and placebo). Conclusions: These data suggest the potential for limited reinforcing and abuse-related subjective effects of intranasal oxytocin. Given the small sample, the greater drug liking of oxytocin compared to placebo, and the positive relation between demand and drug liking, it is possible that oxytocin may produce reinforcing effects in some participants. Therefore, additional studies of oxytocin reinforcement are warranted.
Capabilities for recovery-oriented practice in mental health occupational therapy: A thematic analysis of lived experience perspectives
Authors: Arblaster Karen , Mackenzie Lynette , Gill Katherine , Willis Karen , Matthews Lynda 
Published: September 2019

Introduction Recovery in mental health is both a policy imperative and a contested concept with individual and systemic elements. Occupational therapy research and pre-registration education have not engaged in a substantial way with these ideas, raising questions about how well graduates are equipped for real world practice. We aimed to address this gap by developing lived experience informed recovery-oriented capabilities to inform occupational therapy practice and pre-registration curricula. Method A participatory qualitative approach guided by a consumer reference group was adopted. In-depth interviews were conducted with 16 mental health consumers, wherever possible with a lived experience co-interviewer. Interviews were audio recorded, transcribed verbatim and analysed using thematic analysis. Findings Three core capabilities were developed: knowing, comprising five types of knowledge; doing, focused on three key areas of action in practice; and being/becoming, emphasising the lifelong learning journey of becoming a recovery-oriented practitioner who can ‘be’ in authentic partnerships with consumers to support recovery. Conclusion These lived experience-informed capabilities offer new areas of focus for pre-registration education, practice and research. A need to engage with systemic factors, build students’ capacity for critical thinking about power and structural inequality, and integration of knowledge frameworks through participatory research is suggested.
Electrocardiographic recognition of life-threatening hyperkalaemia: the hyperkalaemic Brugada sign
Authors: McNeill Holly , Isles Chris 
Published: September 2019

Lesson Consider life-threatening hyperkalaemia if the ECG shows high take-off with coved ST segment elevation and negative T wave in lead V1 superimposed on other ECG signs of hyperkalaemia and treat with calcium gluconate while waiting for blood chemistry results.
Structural brain characteristics in treatment-resistant depression: review of magnetic resonance imaging studies
Authors: Klok Margit Philomène C. , van Eijndhoven Philip. F. , Argyelan Miklos , Schene Aart H. , Tendolkar Indira 
Published: September 2019

Background
Major depressive disorder (MDD) has been related to structural brain characteristics that are correlated with the severity of disease. However, the correlation of these structural changes is less well clarified in treatment-resistant depression (TRD).

Aims
To summarise the existing literature on structural brain characteristics in TRD to create an overview of known abnormalities of the brain in patients with MDD, to form hypotheses about the absence or existence of a common pathophysiology of MDD and TRD.

Method
A systematic search of PubMed and the Cochrane Library for studies published between 1998 and August of 2016 investigating structural brain changes in patients with TRD compared with healthy controls or patients with MDD.

Results
Fourteen articles are included in this review. Lower grey matter volume (GMV) in the anterior cingulate cortex, right cerebellum, caudate nucleus, superior/medial frontal gyrus and hippocampus does not seem to differentiate TRD from milder forms of MDD. However, lower GMV in the putamen, inferior frontal gyrus, precentral gyrus, angular- and post-central gyri together with specific mainly parietal white matter tract changes seem to be more specific structural characteristics of TRD.

Conclusions
The currently available data on structural brain changes in patients with TRD compared with milder forms of MDD and healthy controls cannot sufficiently distinguish between a ‘shared continuum hypothesis’ and a ‘different entity hypothesis’. Our review clearly suggests that although there is some overlap in affected brain regions between milder forms of MDD and TRD, TRD also comes with specific alterations in mainly the putamen and parietal white matter tracts.

Declaration of interest
None.
Spz/Toll-6 signal guides organotropic metastasis in Drosophila
Authors: Mishra-Gorur Ketu , Li Daming , Ma Xianjue , Yarman Yanki , Xue Lei , Xu Tian 
Published: September 2019

ABSTRACT
Targeted cell migration plays important roles in developmental biology and disease processes, including in metastasis. Drosophila tumors exhibit traits characteristic of human cancers, providing a powerful model to study developmental and cancer biology. We now find that cells derived from Drosophila eye-disc tumors also display organ-specific metastasis, invading receptive organs but not wing disc. Toll receptors are known to affect innate immunity and the tumor inflammatory microenvironment by modulating the NF-κB pathway. Our RNA interference (RNAi) screen and genetic analyses show that Toll-6 is required for migration and invasion of the tumor cells. Further, receptive organs express Toll ligands [Spätzle (Spz) family molecules], and ectopic Spz expression renders the wing disc receptive to metastasis. Finally, Toll-6 promotes metastasis by activating JNK signaling, a key regulator of cell migration. Hence, we report Toll-6 and Spz as a new pair of guidance molecules mediating organ-specific metastatic behavior and highlight a novel signaling mechanism for Toll-family receptors.
Modulation of TOR complex 2 signaling by the stress-activated MAPK pathway in fission yeast
Authors: Morigasaki Susumu , Chin Lit Chein , Hatano Tomoyuki , Emori Midori , Iwamoto Mika , Tatebe Hisashi , Shiozaki Kazuhiro 
Published: September 2019

ABSTRACT
Sin1 is a substrate-binding subunit of target of rapamycin complex 2 (TORC2), an evolutionarily conserved protein kinase complex. In fission yeast, Sin1 has also been identified as a protein that interacts with Spc1 (also known as Sty1) in the stress-activated protein kinase (SAPK) pathway. Therefore, this study examined the relationship between TORC2 and Spc1 signaling. We found that the common docking (CD) domain of Spc1 interacts with a cluster of basic amino acid residues in Sin1. Although diminished TORC2 activity in the absence of the functional Spc1 cascade suggests positive regulation of TORC2 by Spc1, such regulation appears to be independent of the Sin1–Spc1 interaction. Hyperosmotic stress transiently inhibits TORC2, and its swift recovery is dependent on Spc1, the transcription factor Atf1, and the glycelrol-3-phosphate dehydrogenase Gpd1, whose expression is induced upon osmostress by the Spc1–Atf1 pathway. Thus, cellular adaptation to osmostress seems important for TORC2 reactivation, though Spc1 and Atf1 contribute to TORC2 activation also in the absence of osmostress. These results indicate coordinated actions of the SAPK and TORC2 pathways, both of which are essential for fission yeast cells to survive environmental stress.
Meeting report – Mitotic spindle: from living and synthetic systems to theory
Authors: Simunić Juraj , Subramanian Radhika 
Published: September 2019

ABSTRACT
Leading scientists from the field of mitotic spindle research gathered from 24–27 March 2019 to participate in the first ‘Mitotic spindle: From living and synthetic systems to theory’ conference. This meeting was held in Split, Croatia, organized by Nenad Pavin (Faculty of Science, University of Zagreb) and Iva Tolić (Ruđer Bošković Institute, Zagreb). Around 75 participants presented the latest advances in mitotic spindle research, ranging from live-cell imaging, in vitro reconstitution experiments and theoretical models of spindle assembly. The meeting successfully created an environment for interesting scientific discussions, initiation of new collaborations and development of fresh ideas. In this report, we will highlight and summarize new data challenging the established models of spindle architecture, advances in spindle reconstitution assays, discovery of new regulators of spindle size and shape as well as theoretical approaches for investigating motor protein function.
The Effect of Exercise Timing on Glycemic Control: A Randomized Clinical Trial
Authors: TEO SHAUN Y. M. , KANALEY JILL A. , GUELFI KYM J. , MARSTON KIERAN J. , FAIRCHILD TIMOTHY J. 
Published: September 2019

ABSTRACT
Despite the acknowledgment of exercise as a cornerstone in the management of type 2 diabetes (T2D), the importance of exercise timing has only recently been considered.

Purpose
This study sought to determine the effect of diurnal exercise timing on glycemic control in individuals enrolled in a 12-wk supervised multimodal exercise training program. A secondary aim was to determine the effect of diurnal exercise timing on the circadian rhythm of wrist skin temperature.

Methods
Forty sedentary, overweight adults (mean ± SD, age = 51 ± 13 yr; body mass index = 30.9 ± 4.2 kg·m−2; women, n = 23) with and without (n = 20) T2D diagnosis were randomly allocated to either a morning (amEX) or an evening (pmEX) exercise training group. The supervised 12-wk (3 d·wk−1) program, comprised 30 min of moderate-intensity walking and 4 resistance-based exercises (3 sets, 12–18 repetitions each). Glycemic outcomes (glycated hemoglobin, fasting glucose, postprandial glucose) and wrist skin temperature were assessed at baseline and postintervention.

Results
Exercise training improved (main effect of time, all P < 0.01) all glycemic outcomes; however, this was independent of allocation to either the amEX (Hedge’s g, 0.23–0.90) or the pmEX (Hedge’s g, 0.16–0.90) group. Accordingly, the adopted exercise training program did not alter the circadian rhythm of skin temperature. When only T2D individuals were compared, amEX demonstrated greater effects (all Hedge’s g) on glycated hemoglobin (amEX, 0.57; pmEX, 0.32), fasting glucose (amEX, 0.91; pmEX, 0.53), and postprandial glucose (amEX, 1.12; pmEX, 0.71) but was not statistically different.

Conclusions
Twelve weeks of multimodal exercise training improved glycemic control and postprandial glycemic responses in overweight non-T2D and T2D individuals. However, no distinct glycemic benefits or alterations in circadian rhythm were associated with morning versus evening exercise, when performed three times per week in this cohort.
Are Anterior Cruciate Ligament–reconstructed Athletes More Vulnerable to Fatigue than Uninjured Athletes?
Authors: SMEETS ANNEMIE , VANRENTERGHEM JOS , STAES FILIP , VANDENNEUCKER HILDE , CLAES STEVEN , VERSCHUEREN SABINE 
Published: September 2019

ABSTRACT

Introduction
Fatigue has a negative impact on lower extremity neuromuscular and biomechanical control. Because anterior cruciate ligament reconstruction (ACLR) athletes show already neuromuscular/biomechanical deficits in an unfatigued state, the negative impact of fatigue may magnify these deficits or help expose other deficits. So far, this has only scarcely been assessed warranting further research.

Methods
Twenty-one athletes who had an ACLR and 21 uninjured controls performed five unilateral landing tasks before and after a match simulation protocol, whereas muscle activation (vastus medialis, vastus lateralis, hamstrings medialis, hamstrings lateralis, gastrocnemius medialis, gastrocnemius lateralis, gluteus medius) and landing kinematics and kinetics of the hip, knee, and ankle joint were recorded. A two-way ANOVA with a mixed-model design (main effects for group and fatigue) was used to compare landing kinematics, kinetics, and muscle activation between groups, and prefatigue and postfatigue. To avoid unjustified reduction of the data to discrete values, we used one-dimensional Statistical Parametric Mapping.

Results
Only two interaction effects were found: an increased postfatigue knee abduction moment and an increased postfatigue thorax flexion angle was found in the ACL injured legs but not in the uninjured legs of the ACL group or in the control group, during the lateral hop and the vertical hop with 90° medial rotation, respectively.

Conclusions
This study showed that overall ACLR athletes and uninjured athletes have similar biomechanical and neuromuscular responses to fatigue. For two biomechanical parameters, however, we did find an interaction effect, suggesting that landing deficits in ACLR athletes may become clearer in certain tasks when fatigued.
Body Composition as a Mediator between Cardiorespiratory Fitness and Bone Mass during Growth
Authors: RODRÍGUEZ-GÓMEZ IRENE , MARTÍN-GARCÍA MARÍA , GARCÍA-CUARTERO BEATRIZ , GONZÁLEZ-VERGAZ AMPARO , CARCAVILLA ATILANO , ARAGONÉS ÁNGEL , ALEGRE LUIS M. , ARA IGNACIO 
Published: September 2019

ABSTRACT

Introduction and Purpose
To examine the effect of cardiorespiratory fitness (CRF) and muscle power output (MPO) on bone mass of prepubertal and pubertal children using lean mass (LM) and percentage of fat mass (%FM) as mediator variables. The hypothesis was that both LM and %FM would be independent mediators of the relationships during the sexual maturation period.

Methods
We analyzed 200 children (88 boys and 112 girls [11.5 ± 2.0 yr]). Body composition was analyzed by bone densitometry, and indirect calorimetry and cycle ergometer were used to calculate V˙O2peak (mL·kg−1·min−1) and MPO (W) during an incremental exercise test. Sample was divided by pubertal status.

Results
In the prepubertal group, LM and %FM acted independently as mediators in the relationship between bone mass and CRF or MPO (22%–25% for LM and 37%–50% for %FM, respectively). In pubertal children, LM acted as mediator at 37%.

Conclusions
Although the independent mediator role of LM and %FM in the associations between CRF or MPO and bone mass was present during the prepubertal stage, only LM remain its mediator role in these associations during the postpubertal period. Therefore, with growth and sexual maturation, the full effect of LM seems to increase, whereas the influence of %FM seems to disappear.
Frequency of the phosphatidylinositol3-kinase, catalytic, α-polypeptide gene amplification in ovarian cancer among Sudanese women: a cross-sectional study
Authors: Elmassry Rawia Eljaili , Shrif Nassr Eldin M.A. , Mohammed Aisha Osman , Elaagip Arwa , Husain Nazik Elmalaika 
Published: September 2019

Background: Phosphatidylinositol3-kinase, catalytic, α-polypeptide (PIK3CA) gene is frequently amplified in ovarian carcinoma (OC). To the best of our knowledge, there is a dearth of published reports about the amplification of the PIK3CA gene among Sudanese women with OC. This study aimed to detect the amplification of the PIK3CA gene and its relationship with clinicopathological variables among Sudanese women with OC. Methods: This cross-sectional study included 90 ovarian cases: 83 cases of women diagnosed with OC at Omdurman Maternity Hospital in the period 2013-2018; 7 cases of women with normal ovarian tissues were used as a control to normalize the results. Formalin-fixed paraffin-embedded tissue sections (FFPE) were used to extract RNA at the Institute of Endemic Diseases, Sudan. PIK3CA gene amplification was assessed using quantitative real-time PCR. Results: Amplification of PIK3CA was observed in 33.7% (n = 28/83) of women, with a high frequency in women with clear cell (66.7%; n = 4/6), undifferentiated (50.0%; n = 1/2), serous (35.5%; n = 11/31), mucinous (33.3%; n = 4/12),other (30.8%; n = 4/13), and endometrioid (21.1%; n = 4/19) carcinomas. High frequency was seen in women with higher (39.5%; n = 17/43) rather than in lower grade carcinomas (27.5%; n = 11/40), and in older (43.4%; n = 11/32) rather than younger (30.0%; n = 12/40) women. No significant association between PIK3CA amplification and tumor histologic type, grade, and age of women was observed (Fisher’s Exact test: p = 0.660, 0.698 and 0.687, respectively). Conclusion: PIK3CA gene amplification occurs in about one third of Sudanese women with OC, more frequently in high tumor grades and older women, but not to a statistically significant level. These findings support previous studies suggesting that oncogenic PIK3CA has an essential role in OC progression and may offer a strategy for exact targeted therapy and prognostic evaluation
Case Report: The first probable Hong Kong Chinese case of LPIN1-related acute recurrent rhabdomyolysis in a boy with two novel variants
Authors: Yim Sau Wing , Chan Tina Yee Ching , Belaramani Kiran M. , Man Sze Shun , Wong Felix Chi Kin , Chen Sammy Pak Lam , Lee Hencher Han Chih , Mak Chloe Miu , Ching Chor Kwan 
Published: September 2019

Recurrent rhabdomyolysis is frequently ascribed to fatty acid ß-oxidation defects, mitochondrial respiratory chain disorders and glycogen storage-related diseases. In recent years, autosomal recessive LPIN1 mutations have been identified as a prevailing cause of severe rhabdomyolysis in children in Western countries. We report the first probable Hong Kong Chinese case of recurrent severe rhabdomyolysis in early childhood caused by LPIN1 variants. Compound heterozygous novel variants NM_145693.2(LPIN1):c.[1949_1967dupGTGTCACCACGCAGTACCA]; [2410G>C] (p.[Gly657Cysfs*12];[Asp804His]) were detected. The former variant was classified as likely pathogenic while the latter variant was classified as a variant of uncertain significance (VUS) based on the guideline published by the American College of Medical Genetics and Genomics (ACMG) in 2015. Although the genetic findings were inconclusive, the patient’s presentation was compatible with LPIN1-related acute recurrent rhabdomyolysis, and the patient was treated as such. The early recognition, timely diagnosis and management of this condition are important to avoid fatal consequences. To our knowledge, there has been no previous report in the English-language literature of a child with Chinese ethnicity and LPIN1-related acute recurrent rhabdomyolysis (MIM #268200). Functional characterization of the novel variants detected in this study are warranted in future studies.
Autism and social anxiety in children with sex chromosome trisomies: an observational study
Authors: Wilson Alexander C. , King Judith , Bishop Dorothy V.M. 
Published: September 2019

Background: Recent studies suggest that an extra sex chromosome increases the risk of both autism and social anxiety, but it unclear whether these risks are specific to particular karyotypes. Methods: We considered diagnostic data from an online psychiatric assessment (DAWBA – The Development and Well-Being Assessment) and questionnaire responses completed by parents of children with 47,XXX (N = 29), 47,XXY (N = 28) and 47,XYY (N = 32) karyotypes. Analysis focused mainly on 54 children who were diagnosed prenatally or on the basis of other medical concerns in childhood (Low Bias subgroup), to minimise ascertainment bias. Results: Children with symptoms of autism who fell short of meeting the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria were coded as cases of Pervasive Developmental Disorder Not Otherwise Specified (PDDNOS). The odds ratio of autism or PDDNOS in the Low Bias group was computed relative to gender-specific population norms. This gave log odds ratio (95% confidence interval) of 5.56 (4.25 - 6.88) for XXX girls; 4.00 (2.66 - 5.33) for XXY boys; and 4.60 (3.46 - 5.74) for XYY boys. Despite this elevated risk, most children had no autistic features. A diagnosis of DSM-IV Social Phobia was rare, though, in line with prediction, all three Low Bias cases with this diagnosis had 47,XXY karyotype. All three trisomy groups showed increased risk of milder symptoms of social anxiety. Conclusions: An increased risk of autism was found in girls with 47,XXX karyotype, as well as in boys with 47,XXY or 47,XYY. Symptoms of social anxiety were increased in all three karyotypes. There was wide variation in psychiatric status of children with the same karyotype, suggesting that an extra sex chromosome affects developmental stability in a non-specific way, with a diverse range of possible phenotypes.
Contribution biblio-chronologique à l’étude de la représentation de la littérature canadienne dans la revue polonaise "Literatura na Świecie" (1971-2017)
Authors: Jakubowska Joanna 
Published: September 2019

The Canadian Literature Represented in the Polish Revue Literatura na Świecie – a Bibliographical-Chronological Survey
In this article we propose a survey of the Polish translations of Canadian literature published in the magazine Literatura na Świecie (Literature in the World), from the beginning until the end of 2017. Thus, we try to evaluate the role played by the magazine in spreading and creating a certain image of Canadian literature in Poland. We present our observations in a chronological list which permits to observe the editorial board’s strategy. The article is provided with an appendix containing the bibliographic references of „Canadian” articles published in the monthly.