bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge management as a critical success factor in developing international companies’ organizational learning capability
Authors: Dahou Khadra , Hacini Ishaq , Burgoyne John 
Published: December 2018

Purpose
Organizational learning (OL) represents the real value and the heart of strategic management, the focal point to keep track of international development. This paper aims to investigate the effect of knowledge management (KM) on the development of OL capability (OLC) in international hotels installed in Algeria.

Design/methodology/approach
This deductive descriptive case study research examines the impact of KM, using knowledge conversion process (KCP) on the development of OLC. In all, 70 expatriates were targeted to respond to questionnaires, while only 47 were valid for analysis. Multiple regression analysis is used to analyze the influential processes on OLC.

Findings
The socialization, externalization and internalization have a direct positive significant effect on the development of OLC. Socialization is the major influencing factor. However, the combination has no effect on OLC. In sum, KM has an impact on the development of OLC in international hotels in Algeria.

Practical implications
Exhibiting the strong interdependency between KM and OL, expatriates emphasize on KM as the learning facilitator. The international hotels keen to realize KM as major process to build OLC. Socialization and internalization reinforce learning by providing primordial sophisticated tacit knowledge. Externalization generates expertise and strategic knowledge.

Originality/value
First, the research confirms the effect of KM process using KPC on OLC, stimulating learning at all levels; especially, in a developing Arab country, emphasizing the research’s theoretical contribution. The research is of high contribution, first of a kind in exploring the development of OLC in international hotels in the Algerian context; it is a newly emergent market, in its infancy stage, and an alternative that Algeria tries to boost to steer away from petroleum dependency.
The experiences of grandparents raising grandchildren in Indonesia
Authors: Fauziningtyas Rista , Indarwati Retno , Alfriani Delisa , Haryanto Joni , Ulfiana Elida , Efendi Ferry , Nursalam Nursalam , Abdullah Khatijah Lim 
Published: December 2018

PurposeThe raising of grandchildren by grandparents is a global phenomenon, and it is common in Indonesia. This is because parents are often unable or unwilling to raise their own children. However, the debate around “grandparenting” is still limited in Indonesia. The purpose of this paper is to gain a better understanding of the experience and views of grandparents on “grandparenting.”Design/methodology/approachThe methodology employed was qualitative and informed by phenomenology. The authors conducted in-depth interviews with 13 grandparents who were raising their grandchildren who were under five years old. The data were analyzed using thematic content analysis.Findings5 main themes and 13 subthemes emerged from the analysis of the data. The themes were responses, strategies for overcoming negative responses, the grandparents’ role, the reason for raising grandchildren, and the cultural aspect of “grandparenting” in Java. All of the grandparents enjoyed their roles as grandparents. They felt that they helped fulfill their grandchildren’s physical and educational needs.Social implicationsThe experience of raising a grandchild can be both positive and negative, depending on the cultural aspects in the Java and the family as a whole system. Grandparents require healthcare and informal support to maintain their well-being.Originality/valueThis paper provides new insights into “grandparenting” closely related to social and cultural aspect within the community. Grandparents enjoy being a part of the Javanese tradition. The supportive role of grandparents in Indonesia is important. However, older adults need to balance the role of “grandparenting” and rest time so that they remain healthy and happy.
Retracted: Transforming Growth Factor Beta‐1 Promotes Smooth Muscle Cell Proliferation and Migration in an Arteriovenous Fistulae: The Role of Wall Shear Stress
Authors: Jia Lan , Wei Fang , Wang Lihua , Chen Haiyan , Yu Haibo , Wang Zhe , Jiang Aili 
Published: December 2018

Retraction: Lan Jia, Fang Wei, Lihua Wang, Haiyan Chen, Haibo Yu, Zhe Wang and Aili Jiang “Transforming Growth Factor Beta‐1 Promotes Smooth Muscle Cell Proliferation and Migration in an Arteriovenous Fistulae: The Role of Wall Shear Stress” Therapeutic Apheresis and Dialysis (https://onlinelibrary.wiley.com/doi/10.1111/1744‐9987.12781).The above article, published online on 06 December 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, Tadao Akizawa, and John Wiley and Sons Australia Ltd. The retraction has been agreed due to major overlap with a previously published article.
Emerging concepts and challenges in implementing the exposome paradigm in allergic diseases and asthma: a Practall document
Authors: Agache Ioana , Miller Rachel , Gern James E. , Hellings Peter W. , Jutel Marek , Muraro Antonella , Phipatanakul Wanda , Quirce Santiago , Peden David 
Published: December 2018

AbstractExposome research can improve the understanding of the mechanistic connections between exposures and health to help mitigate adverse health outcomes across the life span. The exposomic approach provides a risk profile instead of single predictors and thus is particularly applicable to allergic diseases and asthma. Under the PRACTALL collaboration between the European Academy of Allergy and Clinical Immunology (EAACI) and the American Academy of Allergy, Asthma, and Immunology (AAAAI), we evaluated the current concepts and the unmet needs on the role of the exposome in allergic diseases and asthma.
Reproducibility of measuring QRS duration and implications for optimization of interventricular pacing delay in cardiac resynchronization therapy
Authors: Stephansen Charlotte , Kronborg Mads Brix , Witt Christoffer Tobias , Kristensen Jens , Gerdes Christian , Sommer Anders , Jensen Jesper Møller , Nielsen Jens Cosedis 
Published: December 2018

AbstractBackgroundQRS narrowing after CRT is a predictor of patient outcome. Further narrowing can be obtained by interventricular pacing delay (VVd) optimization, raising interest to inter and intraobserver variation in manual measurements of QRS duration.Methods(a) Variation in intrinsic rhythm QRS duration in CRT patients with LBBB: In 40 intrinsic 12‐lead ECGs, six observers measured QRS duration defined as widest QRS in any lead. In 20 of these ECGs, two observers repeated the measurements. (b) Variation in paced QRS duration at different VVd settings and agreement in selecting the narrowest QRS: In 20 CRT patients, five paced ECGs were recorded at different VVds. The most frequently selected VVd(s) estimated to cause the narrowest QRS in each patient defined the optimal VVd. Two observers repeated the measurements and VVd selections.ResultsAbsolute interobserver difference in measured QRS duration in intrinsic rhythm ECGs was mean 2 ms, range (−40; 40 ms), mean limits of agreement (LoA): −21; 25 ms. Absolute interobserver difference in measured QRS duration in paced ECGs was mean 3 ms, range (−50; 60 ms), mean LoA: −20; 27 ms. There was no difference in LoA between intrinsic and paced QRS duration (lower limit p = 0.68; upper limit p = 0.44). The optimal VVd was included in 17/20 (85%) of the VVd selections by six observers. Interobserver variation was comparable with the intraobserver variation.ConclusionsInterobserver variation and intraobserver variation in manually measured paced and intrinsic rhythm QRS duration are clinically acceptable and comparable in a cohort of CRT patients. Inter and intraobserver reproducibility for selecting the optimal VVd is good and warrants manual VVd optimization for QRS narrowing in CRT.
Effect of microbial inoculants on the fermentation characteristics, nutritive value, and in vitro digestibility of various forages
Authors: Wang Siran , Li Junfeng , Dong Zhihao , Chen Lei , Shao Tao 
Published: December 2018

AbstractThis study was aimed to examine the characteristics of three isolated lactic acid bacteria (LAB) strains (HG24, M1, and TG1), and to evaluate their effects on fermentation characteristics, nutritive value, and in vitro digestibility in a variety of substrates. The experiments were conducted with Italian ryegrass (Lolium multiflorum Lam.), tall fescue (Festuca arundinacea Schred.), and oat (Avena sativa L.) in laboratory silo (1 L) for ensiling 30 days. All the treated silages had significantly (p < 0.05) higher in vitro dry matter digestibility (IVDMD), and lower undesirable microorganism populations compared with controls. In Italian ryegrass and oat silages, all the inoculants improved the fermentation quality, evidenced by distinctly (p < 0.05) higher LA contents and ratios of LA to acetic acid, and lower pH, butyric acid and ammonia nitrogen contents. Strains HG24 and commercial inoculant G (Lactobacillus plantarum MTD‐1) performed better than strains M1 and TG1, indicated by obviously (p < 0.05) higher LA contents, LAB numbers, and IVDMD. In tall fescue silage, all the isolated LAB strains (HG24, M1 and TG1) markedly (p < 0.05) increased IVDMD compared with strain G. Strain HG24 is recommended as a good LAB inoculant for ensiling in various forages.
Particle size and gastrointestinal absorption influence tiotropium pharmacokinetics: a pilot bioequivalence study of PUR0200 and Spiriva HandiHaler
Authors: Perry Jason , Trautman Brian , Takher‐Smith Joe , Kramer Steve , Kane Katie , Silverman Michael , Tan Lisa , Haughie Scott , Richter Wolfram , Kirkov Valentin , Arsova Sacha , Ward Jonathan , Hava David L. 
Published: December 2018

AimsPlasma pharmacokinetics permit the assessment of efficacy and safety of inhaled drugs, and possibly their bioequivalence to other inhaled products. Correlating drug product attributes to lung deposited dose is important to achieving equivalence. PUR0200 is a spray‐dried formulation of tiotropium that enables more efficient lung delivery than Spiriva® HandiHaler® (HH). The ratio of tiotropium lung‐to‐oral deposition in PUR0200 was varied to investigate the impact of particle size on tiotropium pharmacokinetics, and the contribution of oral absorption to tiotropium exposure was assessed using charcoal block.MethodsA seven‐period, single‐dose, crossover study was performed in healthy subjects. PUR0200 formulations differing in dose and aerodynamic particle size were administered in five periods and Spiriva HH in two periods. In one period, Spiriva HH gastrointestinal absorption was blocked with oral charcoal. Tiotropium plasma concentrations were assessed over 8 h after inhalation.ResultsPUR0200 pharmacokinetics were influenced by aerodynamic particle size and the ratio of lung‐to‐oral deposition, with impactor sized mass (ISM) correlating most strongly with exposure. Formulation PUR0217a (3 μg tiotropium) lung deposition was similar to Spiriva HH (18 μg) with and without charcoal block, but total PUR0200 exposure was lower without charcoal. The Cmax and AUC0–0.5h of Spiriva HH with and without charcoal block were bioequivalent; however, Spiriva HH AUC0–8h was lower when gastrointestinal absorption was inhibited with oral charcoal administration.ConclusionsPharmacokinetic bioequivalence indicative of lung deposition and efficacy can be achieved by matching the reference product ISM. Due to reduced oral deposition and more efficient lung delivery, PUR0200 results in a lower AUC0–t than Spiriva HH due to reduced absorption of drug from the gastrointestinal tract.
Acute effects of zinc and insulin on arcuate anorexigenic proopiomelanocortin neurons
Authors: He Zhenyan , Gao Yong , Lieu Linh , Afrin Sadia , Guo Hongbo , Williams Kevin W 
Published: December 2018

Background and PurposeAcute insulin administration hyperpolarized, with concomitant decrease of firing rate, a subpopulation of arcuate proopiomelanocortin (POMC) and neuropeptide Y/agouti‐related peptide cells. This rapid effect on cellular activity has been proposed as a cellular correlate of insulin effects on energy balance and glucose homoeostasis. Recent evidence suggests that zinc in mammalian insulin formulations is required for the insulin‐induced inhibition of arcuate POMC neurons, while guinea pig insulin, which fails to bind zinc, activates POMC neurons in mice. Here, we tested the effects of zinc and insulin formations on arcuate POMC neurons.Experimental ApproachEffects of zinc and insulin formulations were assessed through whole‐cell patch clamp recordings on transgenic mice in vitro.Key ResultsInsulin formulations containing zinc hyperpolarized POMC neurons. Zinc also hyperpolarized arcuate POMC neurons, albeit at much higher concentration than found in various insulin formulations. Chelation of zinc inhibited the zinc‐induced hyperpolarization of POMC neurons, whereas effects of insulin on POMC cellular activity were unchanged after chelation. Zinc‐free insulin also hyperpolarized arcuate POMC neurons. Insulin failed to hyperpolarize POMC neurons deficient for insulin receptors, suggesting that insulin receptors are required for these effects. Activation of POMC neurons by guinea pig insulin was independent of insulin receptors but was inhibited by PDGF receptor antagonism or loss of TRPC5 channel subunits.Conclusions and ImplicationsTogether, these findings suggest that insulin inhibited arcuate POMC neurons independent of zinc and highlights a possible role of putative PDGF receptors in the acute effects of guinea pig insulin.
Children's Facial Emotion Recognition Skills: Longitudinal Associations With Lateralization for Emotion Processing
Authors: Watling Dawn , Damaskinou Nikoleta 
Published: December 2018

This is the first longitudinal study to evaluate the relations between hemispheric laterality for emotion processing and the development of facial emotion recognition (FER) skills, both of which show similar developmental trajectories. Five to 12‐year‐old children (N = 160) completed an emotion discrimination task, emotion matching task, identity matching task, and behavioral lateralization for emotion processing task at baseline and 1 year later. Lateralization at baseline predicted later emotion discrimination, whereas change in strength of lateralization across the year predicted emotion matching ability. Lateralization was not a significant predictor of identity matching. These findings provide evidence that it is changes in laterality for emotion processing that contribute to improvements in FER skills between 5 and 12 years of age.
Mechanical behavior of posterior all‐ceramic hybrid‐abutment‐crowns versus hybrid‐abutments with separate crowns—A laboratory study
Authors: Nouh Ingy , Kern Matthias , Sabet Ahmed E. , Aboelfadl Ahmad K. , Hamdy Amina M. , Chaar Mohamed S. 
Published: December 2018

AbstractObjectiveThe purpose of this laboratory study was to evaluate the fatigue resistance, fracture resistance and mode of failure of posterior hybrid‐abutment‐crown vs. hybrid‐abutment with separate crown, both bonded to short titanium bases.Materials and MethodsThirty‐two titanium implants were embedded perpendicularly in auto‐polymerizing resin. Implant‐supported restorations simulating a maxillary first premolar were designed and milled using a CAD/CAM system and divided into 2 groups according to material (n = 16): zirconia (Z) and lithium disilicate (L). Each group was subdivided into two subgroups according to design (n = 8): hybrid‐abutment‐crown (ZS, LS) and hybrid‐abutment with separate crown (ZC, LC). Each group was subjected to 1.2 million cycles of thermo‐mechanical fatigue loading in a dual‐axis chewing simulator at 120 N load. Surviving specimens were subjected to quasi‐static loading in a universal testing machine. Mode of failure was determined under a low magnification optical microscope.ResultsDuring chewing simulation, 18.8% of zirconia and 43.8% of lithium disilicate restorations failed. The fracture resistance median values ranged from 3,730 N for group ZC, 3,400 N for group ZS, 1,295 N for group LS to 849 N for group LC. Group ZC had a statistically significant higher fracture resistance than groups LC and LS; however, it did not differ significantly from group ZS (p ≤ 0.05). Failures were seen in both titanium bases and ceramic superstructure.ConclusionsZirconia and lithium disilicate hybrid implant‐supported restorations with short (3 mm) titanium bases failed in a considerable number already during chewing simulation. Therefore, despite their high fracture strength the use in the posterior region should be considered critically.
A revolutionary tool: CRISPR technology plays an important role in construction of intelligentized gene circuits
Authors: Zhou Qun , Zhan Hengji , Liao Xinhui , Fang Lan , Liu Yuhan , Xie Haibiao , Yang Kang , Gao Qunjun , Ding Mengting , Cai Zhiming , Huang Weiren , Liu Yuchen 
Published: December 2018

AbstractWith the development of synthetic biology, synthetic gene circuits have shown great applied potential in medicine, biology, and as commodity chemicals. An ultimate challenge in the construction of gene circuits is the lack of effective, programmable, secure and sequence‐specific gene editing tools. The clustered regularly interspaced short palindromic repeat (CRISPR) system, a CRISPR‐associated RNA‐guided endonuclease Cas9 (CRISPR‐associated protein 9)‐targeted genome editing tool, has recently been applied in engineering gene circuits for its unique properties‐operability, high efficiency and programmability. The traditional single‐targeted therapy cannot effectively distinguish tumour cells from normal cells, and gene therapy for single targets has poor anti‐tumour effects, which severely limits the application of gene therapy. Currently, the design of gene circuits using tumour‐specific targets based on CRISPR/Cas systems provides a new way for precision cancer therapy. Hence, the application of intelligentized gene circuits based on CRISPR technology effectively guarantees the safety, efficiency and specificity of cancer therapy. Here, we assessed the use of synthetic gene circuits and if the CRISPR system could be used, especially artificial switch‐inducible Cas9, to more effectively target and treat tumour cells. Moreover, we also discussed recent advances, prospectives and underlying challenges in CRISPR‐based gene circuit development.
Boa Morte: Reclaiming Kali, reframing death
Authors: Wallace Beverly 
Published: December 2018

AbstractA reframing of an understanding of death using indigenous religious concepts rooted in an African and a Hindu religious worldview is suggested in this article. Using her personal experiences, the author suggests that reclaiming and reframing the concept of death in terms of freedom, as held by the Order of the Sisters of the Good Death in the Candomble religious community of Brazil; representing death in terms of “letting go of ego” as personified by the Hindu Goddess Kali; and seeing death as black and beautiful and of energy as Kali, might be helpful for African Americans. Noting that death and the accompanying hurt and pain of death might move one to action, the need for death rituals is also suggested as a way for the community to begin the healing process, to be reconnected and to be “re‐membered.”
Death and apocalypse in a time of fear
Authors: Trelstad Marit 
Published: December 2018

AbstractThis article explores consequences of perpetuating apocalyptic patterns of thought and proposes that fear‐based responses produce passivity and exacerbate the ends they prophesy. Martin Luther proposed honest, faithful confidence when facing personal death and the end of the world. Catherine Keller stressed that apocalyptic logic and fear excite violence and propagate death. Faithfulness in love, connection to others, and refusal to collapse the world into binaries offer tonic for fear.
Death, the environment, and theology
Authors: Pihkala Panu 
Published: December 2018

AbstractIn order to fare better amidst a growing environmental crisis, we need to face death and mortality in more profound ways. Recent psychosocial research on environmental themes has provided crucial insights. People have trouble dealing with mortality, and because environmental threats remind them (often unconsciously) of death, they tend to escape into non‐sustainable behavior. In this article, I present key insights from this interdisciplinary research and explore its relevance for practicing theologians.
Loss and trauma in Le Fils and Manchester‐by‐the‐Sea: Redemption as resilience
Authors: Nelson Derek R. 
Published: December 2018

AbstractResilience is emerging as a key concept in many disciplines to describe durability of designs, communities, institutions, and even persons. This article considers how “resilience” might be related to the “redemption” of past wrongs committed and evil suffered. Resilience functions as a kind of God‐given holding pattern so that healing can begin and amends be made. Two films, Le Fils (The Son) and Manchester‐by‐the‐Sea, present examples of characters who endure awful trauma, yet who find sources of strength outside of themselves to help keep them open to an experience of redemption.
The voice of patients in system redesign: A case study of redesigning a centralized system for intake of referrals from primary care to rheumatologists for patients with suspected rheumatoid arthritis
Authors: Lopatina Elena , Miller Jean L. , Teare Sylvia R. , Marlett Nancy J. , Patel Jatin , Barber Claire E. H. , Mosher Dianne P. , Wasylak Tracy , Woodhouse Linda J. , Marshall Deborah A. 
Published: December 2018

AbstractBackgroundThe published literature demands examples of health‐care systems designed with the active engagement of patients to explore the application of this complex phenomenon in practice.MethodsThis case study explored how the voice of patients was incorporated into the process of redesigning an element of the health‐care system, a centralized system for intake of referrals from primary care to rheumatologists for patients with suspected rheumatoid arthritis (RA)—centralized intake. The phenomenon of patient engagement using “patient and community engagement researchers” (PaCERs) in research and the process of redesigning centralized intake were selected as the case. In‐depth evaluation of the case was undertaken through the triangulation of findings from the document review and participants’ reflection on the case.ResultsIn this case, patients and PaCERs participated in multiple activities including an initial meeting of key stakeholders to develop the project vision; a patient‐to‐patient PaCERs study to gather perspectives of patients with RA on the challenges they face in accessing and navigating the health‐care system, and what they see as key elements of an effective system that would be responsive to their needs; the development of an evaluation framework for future centralized intake; and the choice of candidate centralized intake strategies to be evaluated.ConclusionsThe described feasible multistep approach to active patient engagement in health‐care system redesign contributes to an understanding of the application of this complex phenomenon in practice. Therefore, the manuscript serves as one more step towards a patient‐centred health‐care system that is redesigned with active patient engagement.