bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrafast z-scanning for high-efficiency laser micro-machining
Authors: Chen Ting-Hsuan , Fardel Romain , Arnold Craig B 
Published: April 2018

AbstractHigh-throughput laser micro-machining demands precise control of the laser beam position to achieve optimal efficiency, but existing methods can be both time-consuming and cost-prohibitive. In this paper, we demonstrate a new high-throughput micro-machining technique based on rapidly scanning the laser focal point along the optical axis using an acoustically driven variable focal length lens. Our results show that this scanning method enables higher machining rates over a range of defocus distances and that the effect becomes more significant as the laser energy is increased. In a specific example of silicon, we achieve a nearly threefold increase in the machining rate, while maintaining sharp side walls and a small spot size. This method has great potential for improving the micro-machining efficiency of conventional systems and also opens the door to applying laser machining to workpieces with uneven topography that have been traditionally difficult to process.
Ultra-broadband on-chip twisted light emitter for optical communications
Authors: Xie Zhenwei , Lei Ting , Li Fan , Qiu Haodong , Zhang Zecen , Wang Hong , Min Changjun , Du Luping , Li Zhaohui , Yuan Xiaocong 
Published: April 2018

AbstractOn-chip twisted light emitters are essential components of orbital angular momentum (OAM) communication devices1, 2. These devices address the growing demand for high-capacity communication systems by providing an additional degree of freedom for wavelength/frequency division multiplexing (WDM/FDM). Although whispering-gallery-mode-enabled OAM emitters have been shown to possess some advantages3, 4, 5, such as compactness and phase accuracy, their inherent narrow bandwidths prevent them from being compatible with WDM/FDM techniques. Here, we demonstrate an ultra-broadband multiplexed OAM emitter that utilizes a novel joint path-resonance phase control concept. The emitter has a micron-sized radius and nanometer-sized features. Coaxial OAM beams are emitted across the entire telecommunication band from 1,450 to 1,650 nm. We applied the emitter to an OAM communication with a data rate of 1.2 Tbit/s assisted by 30-channel optical frequency combs (OFCs). The emitter provides a new solution to further increase capacity in the OFC communication scenario.
Aerodynamic generation of electric fields in turbulence laden with charged inertial particles
Authors: Di Renzo M. , Urzay J. 
Published: April 2018

AbstractSelf-induced electricity, including lightning, is often observed in dusty atmospheres. However, the physical mechanisms leading to this phenomenon remain elusive as they are remarkably challenging to determine due to the high complexity of the multi-phase turbulent flows involved. Using a fast multi-pole method in direct numerical simulations of homogeneous turbulence laden with hundreds of millions of inertial particles, here we show that mesoscopic electric fields can be aerodynamically created in bi-disperse suspensions of oppositely charged particles. The generation mechanism is self-regulating and relies on turbulence preferentially concentrating particles of one sign in clouds while dispersing the others more uniformly. The resulting electric field varies over much larger length scales than both the mean inter-particle spacing and the size of the smallest eddies. Scaling analyses suggest that low ambient pressures, such as those prevailing in the atmosphere of Mars, increase the dynamical relevance of this aerodynamic mechanism for electrical breakdown.
Enhanced pupillary light reflex in infancy is associated with autism diagnosis in toddlerhood
Authors: Nyström Pär , Gliga Teodora , Nilsson Jobs Elisabeth , Gredebäck Gustaf , Charman Tony , Johnson Mark H. , Bölte Sven , Falck-Ytter Terje 
Published: April 2018

AbstractAutism spectrum disorder (ASD) is a neurodevelopmental condition affecting around 1% of the population. We previously discovered that infant siblings of children with ASD had stronger pupillary light reflexes compared to low-risk infants, a result which contrasts sharply with the weak pupillary light reflex typically seen in both children and adults with ASD. Here, we show that on average the relative constriction of the pupillary light reflex is larger in 9–10-month-old high risk infant siblings who receive an ASD diagnosis at 36 months, compared both to those who do not and to low-risk controls. We also found that the magnitude of the pupillary light reflex in infancy is associated with symptom severity at follow-up. This study indicates an important role of sensory atypicalities in the etiology of ASD, and suggests that pupillometry, if further developed and refined, could facilitate risk assessment in infants.
Knowledge acquisition is governed by striatal prediction errors
Authors: Pine Alex , Sadeh Noa , Ben-Yakov Aya , Dudai Yadin , Mendelsohn Avi 
Published: April 2018

AbstractDiscrepancies between expectations and outcomes, or prediction errors, are central to trial-and-error learning based on reward and punishment, and their neurobiological basis is well characterized. It is not known, however, whether the same principles apply to declarative memory systems, such as those supporting semantic learning. Here, we demonstrate with fMRI that the brain parametrically encodes the degree to which new factual information violates expectations based on prior knowledge and beliefs—most prominently in the ventral striatum, and cortical regions supporting declarative memory encoding. These semantic prediction errors determine the extent to which information is incorporated into long-term memory, such that learning is superior when incoming information counters strong incorrect recollections, thereby eliciting large prediction errors. Paradoxically, by the same account, strong accurate recollections are more amenable to being supplanted by misinformation, engendering false memories. These findings highlight a commonality in brain mechanisms and computational rules that govern declarative and nondeclarative learning, traditionally deemed dissociable.
Publisher Correction: Spin-controlled atom–ion chemistry
Authors: Sikorsky Tomas , Meir Ziv , Ben-shlomi Ruti , Akerman Nitzan , Ozeri Roee 
Published: April 2018

The original version of this Article contained an error in the third sentence of the first paragraph of the ‘Spin polarizing the Sr+ ion with ultracold atoms’ section of the Results, which incorrectly read ‘The Langevin collision rate is 1.’ The correct version adds ‘kHz’ after ‘1.’ The fifth sentence of this same paragraph originally read as “Although 87Rb has a I = 3/2 nuclear spin and a hyperfine-split ground-state manifold, 88Sr has no nuclear spin and a Zeeman split two-fold ground state”, which is incorrect. The correct version states “88Sr+” instead of “88Sr”. The first sentence of the fourth paragraph of this same section originally read as “As the collisional energies are on the mK energy scale, spin exchange between Sr+ and Rb prepared in the F = 1 state is allowed only as long as it does not require Rb to change its hyperfine state and climb the 330 m hyperfine energy gap”, which is incorrect. The correct version states “330 mK” instead of “330 m”.In the Discussion section, the text was originally incorrectly repeated.This has been corrected in both the PDF and HTML versions of the Article.
Germination heterochrony in annual plants of Salsola L.: an effective survival strategy in changing environments
Authors: Liu Hua F. , Liu Tong , Han Zhi Q. , Luo Ning , Liu Zun C. , Hao Xiao R. 
Published: April 2018

AbstractGermination heterochrony refers to germination of seeds dispersed in a single growing season, which is different from delayed germination. We studied two year’s demographic characteristics, characteristics of fruit heteromorphism, the relationship between fruit heteromorphism and germination heterochrony, effects of moisture and temperature on germination characteristics, as well as seed longevity of four annual Salsola L. species to analyze the adaptive significance and causes of germination heterochrony. We found that the number of individuals of all populations changed drastically in one year. Approximately 41.6–100% of seedlings germinated in spring died. The number of fruit types varied with interspecies and intraspecies. Despite the wide range of germination temperature of different fruit types (0–35 °C), the germination percentage at 0–15 °C was the highest. When the soil moisture content was 20%, the germination percentage was the highest, reaching 50% within the shortest time. The contrary was the case with the decreasing of soil moisture. The seed longevity of the four species was one year. Fruit heteromorphism had no direct relationship to germination heterochrony. Germination heterochrony was caused by precipitation characteristics and short seed longevity of annual Salsola L., which was an effective survival strategy for plant to adapt to the changing environments in arid area.
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium
Authors: Horne Hisani N. , Oh Hannah , Sherman Mark E. , Palakal Maya , Hewitt Stephen M. , Schmidt Marjanka K. , Milne Roger L. , Hardisson David , Benitez Javier , Blomqvist Carl , Bolla Manjeet K. , Brenner Hermann , Chang-Claude Jenny , Cora Renata , Couch Fergus J. , Cuk Katarina , Devilee Peter , Easton Douglas F. , Eccles Diana M. , Eilber Ursula , Hartikainen Jaana M. , Heikkilä Päivi , Holleczek Bernd , Hooning Maartje J. , Jones Michael , Keeman Renske , Mannermaa Arto , Martens John W. M. , Muranen Taru A. , Nevanlinna Heli , Olson Janet E. , Orr Nick , Perez Jose I. A. , Pharoah Paul D. P. , Ruddy Kathryn J. , Saum Kai-Uwe , Schoemaker Minouk J. , Seynaeve Caroline , Sironen Reijo , Smit Vincent T. H. B. M. , Swerdlow Anthony J. , Tengström Maria , Thomas Abigail S. , Timmermans A. Mieke , Tollenaar Rob A. E. M. , Troester Melissa A. , van Asperen Christi J. , van Deurzen Carolien H. M. , Van Leeuwen Flora F. , Van’t Veer Laura J. , García-Closas Montserrat , Figueroa Jonine D. 
Published: April 2018

AbstractE-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, >2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97–1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06–2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes.
The delta neutrophil index (DNI) as a prognostic marker for mortality in adults with sepsis: a systematic review and meta-analysis
Authors: Ahn Chiwon , Kim Wonhee , Lim Tae Ho , Cho Youngsuk , Choi Kyu-Sun , Jang Bo-Hyoung 
Published: April 2018

AbstractWe performed a meta-analysis to seek evidence for the usefulness of the delta neutrophil index (DNI) as a prognostic blood biomarker for mortality in the early stage of sepsis in adults. A literature search was performed using criteria set forth in a predefined protocol. Studies of adults with sepsis that provided a DNI measurement and that had mortality as the outcome, were included. Review articles, editorials, and non-human studies were excluded. The methodological quality of identified studies was assessed independently by two authors using the Quality in Prognosis Studies (QUIPS) tool. A total of 1,822 patients from eleven studies were ultimately included. Standardized mean differences between non-survivors and survivors were compared. An elevated DNI was associated with mortality in patients with sepsis (standardized mean difference [SMD] 1.22; 95% confidence interval 0.73–1.71; I2 = 91%). After excluding two studies—one that included paediatric patients and one with a disproportionately low mortality rate—heterogeneity was minimized (SMD 0.74, 95% confidence interval 0.53–0.94; I2 = 43%). Overall, the findings suggest that high DNI values are associated with mortality in septic patients.
Extraction of cage-like sporopollenin exine capsules from dandelion pollen grains
Authors: Fan Tengfei , Park Jae Hyeon , Pham Quynh Anh , Tan Ee-Lin , Mundargi Raghavendra. C. , Potroz Michael G. , Jung Haram , Cho Nam-Joon 
Published: April 2018

AbstractPollen-based microcapsules such as hollow sporopollenin exine capsules (SECs) have emerged as excellent drug delivery and microencapsulation vehicles. To date, SECs have been extracted primarily from a wide range of natural pollen species possessing largely spherical geometries and uniform surface features. Nonetheless, exploring pollen species with more diverse architectural features could lead to new application possibilities. One promising class of candidates is dandelion pollen grains, which possess architecturally intricate, cage-like microstructures composed of robust sporopollenin biopolymers. Here, we report the successful extraction and macromolecular loading of dandelion SECs. Preservation of SEC morphology and successful removal of proteinaceous materials was evaluated using scanning electron microscopy (SEM), matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry, elemental CHN analysis, dynamic image particle analysis (DIPA) and confocal laser scanning microscopy (CLSM). Among the tested processing schemes, acidolysis using 85% (v/v) phosphoric acid refluxed at 70 °C for 5 hours yielded an optimal balance of intact particle yield, protein removal, and preservation of cage-like microstructure. For proof-of-concept loading, bovine serum albumin (BSA) was encapsulated within the dandelion SECs with high efficiency (32.23 ± 0.33%). Overall, our findings highlight how hollow microcapsules with diverse architectural features can be readily prepared and utilized from plant-based materials.
Increased transforming growth factor beta (TGF-β) and pSMAD3 signaling in a Murine Model for Contrast Induced Kidney Injury
Authors: Kilari Sreenivasulu , Yang Binxia , Sharma Amit , McCall Deborah L. , Misra Sanjay 
Published: April 2018

AbstractWe tested the hypothesis that post-contrast acute kidney injury (PC-AKI) occurs due to increase in transforming growth factor beta (Tgf-β) and pSMAD3 signaling in a murine model of PC-AKI. Mice had nephrectomy performed and twenty-eight days later, 100-μL of radio-contrast (Vispaque 320) or saline was administered via the jugular vein. Animals were sacrificed at 2, 7, and 28 days later and the serum BUN, creatinine, urine protein levels, and kidney weights were assessed. In human kidney-2 (HK-2) cells, gene and protein expression with cellular function was assessed following inhibition of TGFβR-1 plus contrast exposure. After contrast administration, the average serum creatinine is significantly elevated at all time points. The average gene expression of connective tissue growth factor (Ctgf), Tgfβ-1, matrix metalloproteinase-9 (Mmp-9), and collagen IVa (Col IVa) are significantly increased at 2 days after contrast administration (P < 0.05). Cellular proliferation is decreased and there is increased apoptosis with tubulointerstitial fibrosis. Contrast administered to HK-2 cells results in increased pSMAD3 levels and gene expression of Ctgf, Tgfβ-1, Tgfβ-2, Col IVa, Mmp-9, and caspase/7 activity with a decrease in proliferation (all, P < 0.05). TGFβR-1 inhibition decreased the expression of contrast mediated pro-fibrotic genes in HK-2 cells with no change in the proliferation and apoptosis.
Iron deficiency is associated with Hypothyroxinemia and Hypotriiodothyroninemia in the Spanish general adult population: Di@bet.es study
Authors: Maldonado-Araque Cristina , Valdés Sergio , Lago-Sampedro Ana , Lillo-Muñoz Juan Antonio , Garcia-Fuentes Eduardo , Perez-Valero Vidal , Gutierrez-Repiso Carolina , Goday Albert , Urrutia Ines , Peláez Laura , Calle-Pascual Alfonso , Castaño Luis , Castell Contxa , Delgado Elias , Menendez Edelmiro , Franch-Nadal Josep , Gaztambide Sonia , Girbés Joan , Ortega Emilio , Vendrell Joan , Chacón Matilde R. , Chaves Felipe J. , Soriguer Federico , Rojo-Martínez Gemma 
Published: April 2018

AbstractPrevious studies have suggested that iron deficiency (ID) may impair thyroid hormone metabolism, however replication in wide samples of the general adult population has not been performed. We studied 3846 individuals free of thyroid disease, participants in a national, cross sectional, population based study representative of the Spanish adult population. Thyroid stimulating hormone (TSH), free thyroxin (FT4) and free triiodothyronine (FT3) were analyzed by electrochemiluminescence (E170, Roche Diagnostics). Serum ferritin was analyzed by immunochemiluminescence (Architect I2000, Abbott Laboratories). As ferritin levels decreased (>100, 30–100, 15–30, <15 µg/L) the adjusted mean concentrations of FT4 (p < 0.001) and FT3 (p < 0.001) descended, whereas TSH levels remained unchanged (p = 0.451). In multivariate logistic regression models adjusted for age, sex, UI, BMI and smoking status, subjects with ferritin levels <30 µg/L were more likely to present hypothyroxinemia (FT4 < 12.0 pmol/L p5): OR 1.5 [1.1–2.2] p = 0.024, and hypotriiodothyroninemia (FT3 < 3.9 pmol/L p5): OR 1.8 [1.3–2.6] p = 0.001 than the reference category with ferritin ≥30 µg/L. There was no significant heterogeneity of the results between men, pre-menopausal and post-menopausal women or according to the iodine nutrition status. Our results confirm an association between ID and hypothyroxinemia and hypotriiodothyroninemia in the general adult population without changes in TSH.
RTS,S/AS01 malaria vaccine mismatch observed among Plasmodium falciparum isolates from southern and central Africa and globally
Authors: Pringle Julia C. , Carpi Giovanna , Almagro-Garcia Jacob , Zhu Sha Joe , Kobayashi Tamaki , Mulenga Modest , Bobanga Thierry , Chaponda Mike , Moss William J. , Norris Douglas E. 
Published: April 2018

AbstractThe RTS,S/AS01 malaria vaccine encompasses the central repeats and C-terminal of Plasmodium falciparum circumsporozoite protein (PfCSP). Although no Phase II clinical trial studies observed evidence of strain-specific immunity, recent studies show a decrease in vaccine efficacy against non-vaccine strain parasites. In light of goals to reduce malaria morbidity, anticipating the effectiveness of RTS,S/AS01 is critical to planning widespread vaccine introduction. We deep sequenced C-terminal Pfcsp from 77 individuals living along the international border in Luapula Province, Zambia and Haut-Katanga Province, the Democratic Republic of the Congo (DRC) and compared translated amino acid haplotypes to the 3D7 vaccine strain. Only 5.2% of the 193 PfCSP sequences from the Zambia-DRC border region matched 3D7 at all 84 amino acids. To further contextualize the genetic diversity sampled in this study with global PfCSP diversity, we analyzed an additional 3,809 Pfcsp sequences from the Pf3k database and constructed a haplotype network representing 15 countries from Africa and Asia. The diversity observed in our samples was similar to the diversity observed in the global haplotype network. These observations underscore the need for additional research assessing genetic diversity in P. falciparum and the impact of PfCSP diversity on RTS,S/AS01 efficacy.
Simulating SIR processes on networks using weighted shortest paths
Authors: Tolić Dijana , Kleineberg Kaj-Kolja , Antulov-Fantulin Nino 
Published: April 2018

AbstractWe present a framework to simulate SIR processes on networks using weighted shortest paths. Our framework maps the SIR dynamics to weights assigned to the edges of the network, which can be done for Markovian and non-Markovian processes alike. The weights represent the propagation time between the adjacent nodes for a particular realization. We simulate the dynamics by constructing an ensemble of such realizations, which can be done by using a Markov Chain Monte Carlo method or by direct sampling. The former provides a runtime advantage when realizations from all possible sources are computed as the weighted shortest paths can be re-calculated more efficiently. We apply our framework to three empirical networks and analyze the expected propagation time between all pairs of nodes. Furthermore, we have employed our framework to perform efficient source detection and to improve strategies for time-critical vaccination.
Exotic grass invasion alters microsite conditions limiting woody recruitment potential in an Australian savanna
Authors: Setterfield Samantha A. , Clifton Peter J. , Hutley Lindsay B. , Rossiter-Rachor Natalie A. , Douglas Michael M. 
Published: April 2018

AbstractAndropogon gayanus Kunth. is a large African tussock grass invading Australia’s tropical savannas. Invasion results in more intense fires which increases the mortality rate of adult woody plants. Invasion may also affect community structure by altering the recruitment potential of woody plants. We investigated the effects of A. gayanus invasion on ground-level microclimate, and the carbon assimilation potential and recruitment potential of two Eucalyptus species. We compared microclimatic variables from the early wet-season and into the mid-dry season to coincide with the period of growth of A. gayanus. We assessed Eucalyptus recruitment by monitoring seedling establishment, growth and survival of experimentally sown seed, and estimating seedling density resulting from natural recruitment. A. gayanus invasion was associated with increased grass canopy height, biomass and cover. Following invasion, the understorey microclimate had significantly reduced levels of photon flux density, increased air temperatures and vapour pressure deficit. The conditions were less favourable for woody seedling with aboveground biomass of seedlings reduced by 26% in invaded plots. We estimated that invasion reduced daily carbon assimilation of woody seedlings by ~30% and reduced survivorship of Eucalyptus seedlings. Therefore, A. gayanus invasion reduces recruitment potential, contributing to the transformation of savanna to a grassland ecosystem.