bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Silent Demonstration Acmethod to Improve Students’ Ability on Writing Procedure Text at the Seventh Grade of MTS DDI Pacongang Pinrang
Authors: Sari Fusvita 
Published: September 2018

: This research discussed are the use of silent demonstration method to improve the students ability in writing. This research is conducted using a quasi-experimental method was carried out. The population of the research was the Seventh grade of Mts DDI PacongangPinrang in academy years 2014- 2015 which consisted of two classes VII a and VII b were taken as the sample which consist of (30 students). The sample was drawn using cluster random sampling technique. While class VII B was chosen as the experimental group, while VII a was chosen as control group. The instrument for collecting data were writing test. The data obtained through the test were analyzed using t-test.The result of this research was use of silent demonstration significant difference with the use of conventional away / direct instruction (English book / script) of the students writing ability.This Indicate the mean the experimental group is higher than control group (75.8 > 68.83).There was also the result of t-test value is higher than t-table value (8.648 > 1.671) In other word hypothesis ) is that null hypothesis ( Ho) is rejected and Hypothesis Alternative (H1) is accepted. It is concluded ; the writing ability the seventh grade students of MTs DDI PacongangPinrang be improved through silent demonstration method by procedure text .
Management of treatment-resistant depression in primary care: a mixed-methods study
Authors: Wiles Nicola , Taylor Abigail , Turner Nicholas , Barnes Maria , Campbell John , Lewis Glyn , Morrison Jill , Peters Tim J , Thomas Laura , Turner Katrina , Kessler David 
Published: September 2018

BackgroundNon-response to antidepressant medication is common in primary care. Little is known about how GPs manage patients with depression that does not respond to medication.AimTo describe usual care for primary care patients with treatment-resistant depression (TRD).Design and settingMixed-methods study using data from a UK primary care multicentre randomised controlled trial.MethodIn total, 235 patients with TRD randomised to continue with usual GP care were followed up at 3-month intervals for a year. Self-report data were collected on antidepressant medication, number of GP visits, and other treatments received. In addition, 14 semi-structured face-to-face interviews were conducted with a purposive sample after the 6-month follow-up and analysed thematically.ResultsMost patients continued on the same dose of a single antidepressant between baseline and 3 months (n = 147/186 at 3 months, 79% (95% confidence interval [CI] = 73 to 85%)). Figures were similar for later follow-ups (for example, 9–12 months: 72% (95% CI = 63 to 79%). Medication changes (increasing dose; switching to a different antidepressant; adding a second antidepressant) were uncommon. Participants described usual care mainly as taking antidepressants, with consultations focused on other (physical) health concerns. Few accessed other treatments or were referred to secondary care.ConclusionUsual care in patients with TRD mainly entailed taking antidepressants, and medication changes were uncommon. The high prevalence of physical and psychological comorbidity means that, when these patients consult, their depression may not be discussed. Strategies are needed to ensure the active management of this large group of patients whose depression does not respond to antidepressant medication.
Prevalence of drug–herb and drug–supplement interactions in older adults: a cross-sectional survey
Authors: Agbabiaka Taofikat B , Spencer Neil H , Khanom Sabina , Goodman Claire 
Published: September 2018

BackgroundPolypharmacy is common among older adults, with increasing numbers also using prescription drugs with herbal medicinal products (HMPs) and dietary supplements. There is no reliable evidence from the UK on concurrent use of HMPs and dietary supplements with prescription drugs in older adults.AimTo establish prevalence of concurrent prescription drugs, HMPs, and dietary supplements among UK community-dwelling older adults and identify potential interactions.Design and settingCross-sectional survey of older adults registered at two general practices in South East England.MethodA questionnaire asking about prescription medications, HMPs, and sociodemographic information was posted to 400 older adults aged ≥65 years, identified as taking ≥1 prescription drug.ResultsIn total 155 questionnaires were returned (response rate = 38.8%) and the prevalence of concurrent HMPs and dietary supplements with prescriptions was 33.6%. Females were more likely than males to be concurrent users (43.4% versus 22.5%; P = 0.009). The number of HMPs and dietary supplements ranged from 1 to 8, (mean = 3, median = 1; standard deviation = 1.65). The majority of concurrent users (78.0%) used dietary supplements with prescription drugs. The most commonly used dietary supplements were cod liver oil, glucosamine, multivitamins, and vitamin D. Others (20.0%) used only HMPs with prescription drugs. Common HMPs were evening primrose oil, valerian, and Nytol Herbal® (a combination of hops, gentian, and passion flower). Sixteen participants (32.6%) were at risk of potential adverse drug interactions.ConclusionGPs should routinely ask questions regarding herbal and supplement use, to identify and manage older adults at potential risk of adverse drug interactions.
Releasing GP capacity with pharmacy prescribing support and New Ways of Working: a prospective observational cohort study
Authors: Maskrey Margaret , Johnson Chris F , Cormack Jason , Ryan Margaret , Macdonald Hector 
Published: September 2018

BackgroundGeneral practice in the UK is experiencing a workforce crisis. However, it is unknown what impact prescribing support teams may have on freeing up GP capacity and time for clinical activities.AimTo release GP time by providing additional prescribing resources to support general practices between April 2016 and March 2017.Design and settingProspective observational cohort study in 16 urban general practices that comprise Inverclyde Health and Social Care Partnership in Scotland.MethodGPs recorded the time they spent dealing with special requests, immediate discharges, outpatient requests, and other prescribing issues for 2 weeks prior to the study and for two equivalent periods during the study. Specialist clinical pharmacists performed these key prescribing activities to release GP time and Read coded their activities. GP and practice staff were surveyed to assess their expectations at baseline and their experiences during the final data-collection period. Prescribing support staff were also surveyed during the study period.ResultsGP time spent on key prescribing activities significantly reduced by 51% (79 hours, P<0.001) per week, equating to 4.9 hours (95% confidence interval = 3.4 to 6.4) per week per practice. The additional clinical pharmacist resource was well received and appreciated by GPs and practices. As well as freeing up GP capacity, practices and practitioners also identified improvements in patient safety, positive effects on staff morale, and reductions in stress. Prescribing support staff also indicated that the initiative had a positive impact on job satisfaction and was considered sustainable, although practice expectations and time constraints created new challenges.ConclusionSpecialist clinical pharmacists are safe and effective in supporting GPs and practices with key prescribing activities in order to directly free GP capacity. However, further work is required to assess the impact of such service developments on prescribing cost-efficiency and clinical pharmacist medication review work.
Continuum and Spectral Line Radiation from a Random Clumpy Medium
Authors: Conway John E. , Elitzur Moshe , Parra Rodrigo 
Published: September 2018

Abstract
We present a formalism for continuum and line emission from random clumpy media together with its application to problems of current interest, including CO spectral lines from ensembles of clouds and radio emission from H ii regions, supernovae, and star-forming regions. For line emission, we find that the effects of clump opacity on observed line ratios can be indistinguishable from variations of intrinsic line strengths, adding to the difficulties in determining abundances from line observations. Our formalism is applicable to arbitrary distributions of cloud properties, provided the cloud volume filling factor is small; numerical simulations show it to hold up to filling factors of ∼10%. We show that irrespective of the complexity of the cloud ensemble, the radiative effect of clumpiness can be parameterized at each frequency by a single multiplicative correction to the overall optical depth; this multiplier is derived from appropriate averaging over individual cloud properties. Our main finding is that cloud shapes have only a negligible effect on radiation propagation in clumpy media; the results of calculations employing point-like clouds are practically indistinguishable from those for finite-sized clouds with arbitrary geometrical shapes.
Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy
Authors: Badamchi-Zadeh Alexander , Moynihan Kelly D. , Larocca Rafael A. , Aid Malika , Provine Nicholas M. , Iampietro M. Justin , Kinnear Ekaterina , Penaloza-MacMaster Pablo , Abbink Peter , Blass Eryn , Tregoning John S. , Irvine Darrell J. , Barouch Dan H. 
Published: September 2018

Abstract
The combined inhibition of histone deacetylases (HDAC) and the proteins of the bromodomain and extraterminal (BET) family have recently shown therapeutic efficacy against melanoma, pancreatic ductal adenocarcinoma, testicular, and lymphoma cancers in murine studies. However, in such studies, the role of the immune system in therapeutically controlling these cancers has not been explored. We sought to investigate the effect of the HDAC inhibitor romidepsin (RMD) and the BET inhibitor IBET151, both singly and in combination, on vaccine-elicited immune responses. C57BL/6 mice were immunized with differing vaccine systems (adenoviral, protein) in prime-boost regimens under treatment with RMD, IBET151, or RMD+IBET151. The combined administration of RMD+IBET151 during vaccination resulted in a significant increase in the frequency and number of Ag-specific CD8+ T cells. RMD+IBET151 treatment significantly increased the frequency of vaccine-elicited IFN-γ+ splenic CD8+ T cells and conferred superior therapeutic and prophylactic protection against B16-OVA melanoma. RNA sequencing analyses revealed strong transcriptional similarity between RMD+IBET151 and untreated Ag-specific CD8+ T cells except in apoptosis and IL-6 signaling–related genes that were differentially expressed. Serum IL-6 was significantly increased in vivo following RMD+IBET151 treatment, with recombinant IL-6 administration replicating the effect of RMD+IBET151 treatment on vaccine-elicited CD8+ T cell responses. IL-6 sufficiency for protection was not assessed. Combined HDAC and BET inhibition resulted in greater vaccine-elicited CD8+ T cell responses and enhanced therapeutic and prophylactic protection against B16-OVA melanoma. Increased IL-6 production and the differential expression of pro- and anti-apoptotic genes following RMD+IBET151 treatment are likely contributors to the enhanced cancer vaccine responses.
Entorno Docente Universitario para la Programación de los Robots
Authors: Cañas Plaza José María , Martín Florido Alberto , Perdices García Eduardo , Rivas Montero Francisco , Calvo Palomino Roberto 
Published: September 2018

Se presenta un entorno docente de robótica universitaria orientado al aprendizaje práctico. Es software libre, multiplataforma (Linux, Windows, MacOS) y hace énfasis en la programación de la inteligencia de los robots. Consta de una colección de prácticas variadas, cercanas a las aplicaciones robóticas que están llegando a la sociedad recientemente (coches autónomos, drones, aspiradoras...).Utiliza el simulador Gazebo como referencia y Python como lenguaje. Para cada práctica se ha programado una aplicación académica que realiza tareas auxiliares como la interfaz gráfica, la conexión con sensores y actuadores concretos, la temporización, etc. y aloja al código del estudiante, que así se concentra en los algoritmos de percepción y control. Cada aplicación está formada por una parte específica preparada, que queda oculta, y el código del estudiante, que simplemente rellena un sencillo fichero plantilla con la lógica del robot. Se ha utilizado con éxito en varios cursos de grado, de máster y cursos de introducción a la robótica.
The Art of Judicious Lying
Authors: Camfield Gregg 
Published: September 2018

Abstract
When he began writing Adventures of Huckleberry Finn, Mark Twain believed in an Enlightenment idea of progress and focused much of his satirical energy attacking literalist religion as a vestige of a more primitive state of human civilization. He called these vestiges lies. By the time he shifted his focus to the problem of racism, he began to doubt the idea of progress, wondering instead whether all cultures are fundamentally based on lies and therefore impervious to direct efforts to promote progress. He postulated instead that judicious lying is the best tool to improve humankind.
Reading, Writing, and “Riffmatic”: Using Twain in a Writing Class
Authors: Gatten John T. 
Published: September 2018

Abstract
Using Mark Twain's letters and short works in a beginning fiction writing class can be very fruitful because in them students can see ways Twain views the role of setting in developing new stories, constructs humorous situations that can be imitated by students, and projects dialogue for a particular audience in a manner that is similar to that of a jazz musician. This article develops an awareness of how composition in a story can lead to the composition of relationships in the outside world. This brief discussion offers ways of looking at Twain's work for insights into writing and teaching creative writing. It is not so much about how to write as it about using the creative process to get a class involved.
Families at Play
Authors: Siyahhan Sinem , Gee Elisabeth 
Published: September 2018

Video games have a bad reputation in the mainstream media. They are blamed for encouraging social isolation, promoting violence, and creating tensions between parents and children. In this book, Sinem Siyahhan and Elisabeth Gee offer another view. They show that video games can be a tool for connection, not isolation, creating opportunities for families to communicate and learn together. Siyahhan and Gee offer examples of how video games, like smartphones, Skype, and social media, help families stay connected. Further, they describe how families express their feelings and share their experiences and understanding of the world through playing video games like Sims, Civilization, and Minecraft. When designed intentionally to support families, video games can also create conversations around such real-world issues and sensitive topics as bullying and peer pressure. Siyahhan and Gee draw on a decade of research to look at how learning and teaching take place when families play video games together. With video games, they argue, the parents are not necessarily the teachers and experts; all family members can be both teachers and learners. They suggest video games can help families form, develop, and sustain their learning culture as well as develop skills that are valued in the twenty-first century workplace. Finally, Siyahhan and Gee share recommendations for educators and game designers who are interested in supporting intergenerational play around video games.
Identification of an aquaculture poriferan “Pest with Potential” and its phylogenetic implications
Authors: Galitz Adrian , Cook Steve de C. , Ekins Merrick , Hooper John N. A. , Naumann Peter T. , de Voogd Nicole J. , Abdul Wahab Muhammad , Wörheide Gert , Erpenbeck Dirk 
Published: September 2018

Correct identification and classification of sponges is challenging due to ambiguous or misleading morphological features. A particular case is a blue keratose sponge occasionally referred to as the “Blue Photo Sponge” among aquarists, which appears frequently (and in several cases unintended) in private aquaria. This spicule-less species, occasionally specified as Collospongia auris Bergquist, Cambie & Kernan 1990, not only displays a high phenotypic plasticity in growth form and colour, it also proliferates in aquacultures under standard conditions unlike most other sponges. Therefore, this species is regarded as a pest for most aquarists. In turn, the ease of cultivation and propagation in aquacultures qualifies this species as a model organism for a wide array of scientific applications. For these purposes, correct identification and classification are indispensable. We reconstructed ribosomal gene trees and determined this species as Lendenfeldia chondrodes (De Laubenfels, 1954) (Phyllospongiinae), distant to Collospongia auris, and corroborated by skeletal features. Additionally, the resulting phylogeny corroborated major shortcomings of the current Phyllospongiinae classification—its consequences are discussed.
Plurality in multi-disciplinary research: multiple institutional affiliations are associated with increased citations
Authors: Sanfilippo Paul , Hewitt Alex W. , Mackey David A. 
Published: September 2018

Background
The institutional affiliations and associated collaborative networks that scientists foster during their research careers are salient in the production of high-quality science. The phenomenon of multiple institutional affiliations and its relationship to research output remains relatively unexplored in the literature.

Methods
We examined 27,612 scientific articles, modelling the normalized citation counts received against the number of authors and affiliations held.

Results
In agreement with previous research, we found that teamwork is an important factor in high impact papers, with average citations received increasing concordant with the number of co-authors listed. For articles with more than five co-authors, we noted an increase in average citations received when authors with more than one institutional affiliation contributed to the research.

Discussion
Multiple author affiliations may play a positive role in the production of high-impact science. This increased researcher mobility should be viewed by institutional boards as meritorious in the pursuit of scientific discovery.
Clinical and infarction patterns of PFO‐related cryptogenic strokes and a prediction model
Authors: He Dan , Shi Qiang , Xu Guangjing , Hu Zheng , Li Xuefei , Li Qian , Guo Yinping , Xu Shabei , Lin Yongbo , Yu Zhiyuan , Wang Wei , Luo Xiang 
Published: September 2018

AbstractObjectivesThe higher than expected PFO rate in CS patients has raised concerns that paradoxical embolism maybe the pathophysiologic mechanism for strokes. However, only a small proportion of pathogenic PFOs cause CS. Therefore, accurate recognition of patients with pathogenic PFOs among all CS patients could guide clinical decision making in selecting the most appropriate treatment. The aim of this study was to devise a new algorithm to stratify cryptogenic stroke (CS) patients into pathogenic patent foramen ovale (p‐PFO)‐ and non‐p‐PFO‐related patients.MethodsA total of 1201 patients with acute ischemic stroke were recruited from two different medical centers, and 253 CS patients were identified. Of the 253 patients, 111 were diagnosed with PFO using contrast transcranial Doppler. Data on medical histories, neuroimaging and laboratory tests were compared in CS patients with or without PFO.ResultsCompared with PFO‐negative CS patients, PFO‐positive CS patients showed younger onset age, lower incidence of hypertension and dyslipidemia, characteristic infarction pattern in magnetic resonance imaging and specifically altered platelet activity and coagulation function. Based on the above information, we constructed a PFO judgment formula (Hr‐PFOJ) by means of feature weight estimation and predictive performance evaluation to predict pathogenic PFO in CS patients with a sensitivity of 76.3% and a specificity of 66.5%.InterpretationsHr‐PFOJ judgment formula is a useful screening tool for identification of patients with pathogenic PFO who may benefit from PFO‐related treatment.
Chip‐Based Heat Stimulation for Modulating Signal Propagation in HL‐1 Cell Networks
Authors: Dang Ka My , Rinklin Philipp , Afanasenkau Dzmitry , Westmeyer Gil , Schürholz Tobias , Wiegand Simone , Wolfrum Bernhard 
Published: September 2018

AbstractSignal propagation in cardiac cell networks can be modulated by heat stimulation. Here, the response of a connected HL‐1 cardiomyocyte cell network to the application of confined heat stimuli using Ca2+imaging is investigated. Localized temperature gradients are generated by resistive heating via microwire arrays on a chip surface, which serves as a substrate for growing a confluent cell network. It is demonstrated that upon heat stimulation, the velocity of the propagating Ca2+wave in the network is locally increased, leading to a deformation of the wavefront. Furthermore, evidence of a change in the signal propagation direction caused by a relocation of the pacemaker cell is shown. This effect might be used in future applications, where heat is employed as an alternative modality for cell stimulation protocols.
Microfluidics‐Assisted Fabrication of Microtissues with Tunable Physical Properties for Developing an In Vitro Multiplex Tissue Model
Authors: Lee Dongjin , Lee Kangseok , Cha Chaenyung 
Published: September 2018

AbstractHerein, a new 3D hydrogel‐based co‐culture tissue model is developed to systematically examine the effect of mutual influence between two different cell types residing in separated but interactive zones. Microtissues containing macrophage as a model cell type are first developed by photo‐crosslinking cell‐laden droplets containing methacrylic gelatin (MGel), using a microfluidic flow‐focusing device. Regardless of the material conditions, the cell viability is well maintained, demonstrating the biocompatibility of the fabrication process as well as the 3D microenvironment provided by the microgels. More significantly, it is shown that the proliferation and lipopolysaccharide (LPS)‐induced differentiation (Mφ polarization) of macrophages are heavily influenced by the mechanical properties of the microgels, controlled with MGel concentrations. Eventually, these macrophage microtissues are embedded into a larger tissue construct, containing either normal or cancer cells, to develop a co‐culture tissue model to study the mutual effects between macrophages in different stages of differentiation and the surrounding cells. It is expected that this “multiplex” tissue model would allow an effective platform for monitoring of complex interactions between two different cell types residing in adjacent, compartmentalized areas within a 3D tissue environment.