bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatic delineation of debris-covered glaciers using InSAR coherence derived from X-, C- and L-band radar data: a case study of Yazgyl Glacier
Authors: LIPPL STEFAN , VIJAY SAURABH , BRAUN MATTHIAS 
Published: September 2018

ABSTRACTDespite their importance for mass-balance estimates and the progress in techniques based on optical and thermal satellite imagery, the mapping of debris-covered glacier boundaries remains a challenging task. Manual corrections hamper regular updates. In this study, we present an automatic approach to delineate glacier outlines using interferometrically derived synthetic aperture radar (InSAR) coherence, slope and morphological operations. InSAR coherence detects the temporally decorrelated surface (e.g. glacial extent) irrespective of its surface type and separates it from the highly coherent surrounding areas. We tested the impact of different processing settings, for example resolution, coherence window size and topographic phase removal, on the quality of the generated outlines. We found minor influence of the topographic phase, but a combination of strong multi-looking during interferogram generation and additional averaging during coherence estimation strongly deteriorated the coherence at the glacier edges. We analysed the performance of X-, C- and L- band radar data. The C-band Sentinel-1 data outlined the glacier boundary with the least misclassifications and a type II error of 0.47% compared with Global Land Ice Measurements from Space inventory data. Our study shows the potential of the Sentinel-1 mission together with our automatic processing chain to provide regular updates for land-terminating glaciers on a large scale.
r-FREDHOLM THEORY IN BANACH ALGEBRAS
Authors: BENJAMIN RONALDA , LAUSTSEN NIELS JAKOB , MOUTON SONJA 
Published: September 2018

AbstractHarte (1982, Math. Z. 179, 431–436) initiated the study of Fredholm theory relative to a unital homomorphism T: A → B between unital Banach algebras A and B based on the following notions: an element a ∈ A is called Fredholm if 0 is not in the spectrum of Ta, while a is Weyl (Browder) if there exist (commuting) elements b and c in A with a = b + c such that 0 is not in the spectrum of b and c is in the null space of T. We introduce and investigate the concepts of r-Fredholm, r-Weyl and r-Browder elements, where 0 in these definitions is replaced by the spectral radii of a and b, respectively.
Bank Lending and the European Sovereign Debt Crisis
Authors: De Marco Filippo 
Published: September 2018

I investigate whether bank exposures to sovereign debt during the European debt crisis affected the real economy. I show that a shock to the marked-to-market (MTM) value of bank exposures to sovereign debt led to credit tightening in 2010–2011 that had negative real effects on small and young firms. Because banks do not usually mark their holdings of sovereign bonds to market, I explore the transmission channels of the unrealized losses on credit supply. I show that a shock to MTM exposures reduced short-term bank funding from U.S. money market funds rather than affecting equity or working through alternative channels.
Flannery O'Connor and religious epistemology
Authors: BAEHR JASON 
Published: September 2018

AbstractWhat are the demands of religious inquiry? It can be tempting to think of these demands in strictly epistemic terms, e.g. as a function of the inquirer's background beliefs, cognitive faculties, natural cognitive ability, intellectual skills, and intellectual character. In this article, I extrapolate an alternative model of religious inquiry from three stories by the Southern Gothic writer Flannery O'Connor (1925–1964). According to the model, a person's fitness for religious inquiry also depends on whether she possesses a certain moral posture. In particular, I argue that something like moral humility functions as an epistemic virtue in the theistic domain.
What the argument from evil should, but cannot, be
Authors: COLLIN JAMES HENRY 
Published: September 2018

AbstractMichael Tooley has developed a sophisticated evidential version of the argument from evil that aims to circumvent sceptical theist responses. Evidential arguments from evil depend on the plausibility of inductive inferences from premises about our inability to see morally sufficient reasons for God to permit evils to conclusions about there being no morally sufficient reasons for God to permit evils. Tooley's defence of this inductive step depends on the idea that the existence of unknown rightmaking properties is no more likely, a priori, than the existence of unknown wrongmaking properties. I argue that Tooley's argument begs the question against the theist, and, in doing so, commits an analogue of the base rate fallacy. I conclude with some reflections on what a successful argument from evil would have to establish.
Revisiting the form and function of conflict: Neurobiological, psychological, and cultural mechanisms for attack and defense within and between groups
Authors: De Dreu Carsten K. W. , Gross Jörg 
Published: September 2018

AbstractConflict can profoundly affect individuals and their groups. Oftentimes, conflict involves a clash between one side seeking change and increased gains through victory and the other side defending the status quo and protecting against loss and defeat. However, theory and empirical research largely neglected these conflicts between attackers and defenders, and the strategic, social, and psychological consequences of attack and defense remain poorly understood. To fill this void, we model (1) the clashing of attack and defense as games of strategy and reveal that (2) attack benefits from mismatching its target's level of defense, whereas defense benefits from matching the attacker's competitiveness. This suggests that (3) attack recruits neuroendocrine pathways underlying behavioral activation and overconfidence, whereas defense invokes neural networks for behavioral inhibition, vigilant scanning, and hostile attributions; and that (4) people invest less in attack than defense, and attack often fails. Finally, we propose that (5) in intergroup conflict, out-group attack needs institutional arrangements that motivate and coordinate collective action, whereas in-group defense benefits from endogenously emerging in-group identification. We discuss how games of attack and defense may have shaped human capacities for prosociality and aggression, and how third parties can regulate such conflicts and reduce their waste.
The invasive speciesCylindrodesmus hirsutusPocock (Diplopoda: Polydesmida: Haplodesmidae) spreads to the northern Caribbean, with a compilation of published localities
Authors: Recuero Ernesto 
Published: September 2018

AbstractMillipede diversity in tropical regions, and in Mexico in particular, is still mostly unknown. A modest but recurrent source of new Mexican species is the colonization of exotic species, due to human activity. The invasive speciesCylindrodesmus hirsutusPocock, 1889 has spread from its area of origin in Indonesia or Melanesia and become a virtually pantropical species. Although long known from South and Central America, reports from the Caribbean are sparse and limited to some eastern islands and southern Central America. On 9 March 2016, two adult specimens were found on Cozumel Island, Quintana Roo, in an area of medium semideciduous tropical forest. This paper comprises the first record of this species from Mexico and the northern Caribbean. Given the intense commercial activity in the region, the presence of more populations both in Cozumel Island and in the mainland coast is highly probable.
Temperature Trends and Anomalies in Modern Satellite Data: Infrared Sounding and GPS Radio Occultation
Authors: Leroy S. S. , Ao C. O. , Verkhoglyadova O. P. 
Published: September 2018

AbstractTrends in monthly average, zonal average temperature in the stratosphere as retrieved from highly accurate modern satellite data are intercompared and compared with climate reanalyses from 2003 through 2014. The data sets used are those of Atmospheric Infrared Sounder and Global Positioning System (GPS) radio occultation, and the reanalyses are those of MERRA and ERA‐Interim. Trends produced by all data sets agree to within 0.02 K/year in the lower stratosphere and 0.05 K/year in the middle stratosphere. A number of retrieval errors are found that introduce incorrect trends and seasonal anomalies. Adding microwave data to the infrared retrieval changes trends by approximately 0.01 K/year, thus improving agreement with the other data sets. The signature of the quasi‐biennial oscillation in temperature and the annual cycle of temperature over Antarctica as retrieved from infrared data contain null‐space errors of more than 3 K due to erroneous priors used in retrieval. Nonuniformity in GPS radio occultation gives rise to errors because changes in received GPS signal strength alter the upper boundary initialization in radio occultation retrieval. Finally, an incorrect specification of atmospheric water vapor introduces an erroneous seasonal cycle of temperature as retrieved from GPS radio occultation data in the upper troposphere. All of these time‐dependent retrieval errors can be corrected with future research and improvements to spectral infrared and GPS radio occultation retrieval systems.
Estimation of Marine Versus Terrigenous Organic Carbon in Sediments Off Southwestern Taiwan Using the Bromine to Total Organic Carbon Ratio as a Proxy
Authors: Kandasamy Selvaraj , Lin Baozhi , Lou Jiann‐Yuh , Kao Shuh‐Ji , Chen Chen‐Tung Arthur , Mayer Lawrence M. 
Published: September 2018

AbstractWe measured bromine to total organic carbon (Br:TOC) ratios as an organic source indicator in terrestrial and marine settings of Taiwan, a tectonically active margin that differs from previously studied, passive margins. Terrestrial lake sediments, soils, and river bed and suspended sediments showed Br:TOC ratios ranging from 0.02 to 2.8 mg‐Br/g‐TOC. In ocean margin sediments, Br:TOC ratios ranged from terrigenous values up to 7.6 mg‐Br/g‐TOC. A two‐component Br:TOC mixing model for ocean margin sediments indicates roughly equal proportions of terrigenous and marine organic matter (FT and FM, respectively). Terrestrial δ13C values varied from −31.5 to −24.7‰, a range which is twice the difference between the isotopic terrigenous and marine end‐members used to calculate these proportions. FT and FM based on δ13C were similar to those using Br:TOC if averaged across all marine sediments but often differed at the level of individual samples. Depth profiles of amounts of these two forms of organic matter (OCterr and OCmar) using Br:TOC ratios show that OCmar burial is relatively constant while OCterr and hence TOC vary more strongly; this pattern suggests either episodic terrigenous carbon inputs or winnowing before burial. Variations in TOC:TN and δ13C are consistent with this control of TOC by terrigenous carbon. This study validates Br:TOC as a source indicator for terrigenous versus marine‐derived organic matter in sediments derived from mountainous areas in Oceania. As a single parameter source indicator it should have less error than δ13C due to less uncertainty of the terrestrial end‐member.
Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses
Authors: Fouda Abdelrahman Y. , Xu Zhimin , Shosha Esraa , Lemtalsi Tahira , Chen Jijun , Toque Haroldo A. , Tritz Rebekah , Cui Xuezhi , Stansfield Brian K. , Huo Yuqing , Rodriguez Paulo C. , Smith Sylvia B. , Caldwell R. William , Narayanan S. Priya , Caldwell Ruth B. 
Published: September 2018

AbstractThe lack of effective therapies to limit neurovascular injury in ischemic retinopathy is a major clinical problem. This study aimed to examine the role of ureohydrolase enzyme, arginase 1 (A1), in retinal ischemia-reperfusion (IR) injury. A1 competes with nitric oxide synthase (NOS) for their common substratel-arginine. A1-mediatedl-arginine depletion reduces nitric oxide (NO) formation by NOS leading to vascular dysfunction when endothelial NOS is involved but prevents inflammatory injury when inducible NOS is involved. Studies were performed using wild-type (WT) mice, global A1+/−knockout (KO), endothelial-specific A1 KO, and myeloid-specific A1 KO mice subjected to retinal IR injury. Global as well as myeloid-specific A1 KO mice showed worsened IR-induced neuronal loss and retinal thinning. Deletion of A1 in endothelial cells had no effect, while treatment with PEGylated (PEG) A1 improved neuronal survival in WT mice. In addition, A1+/−KO mice showed worsened vascular injury manifested by increased acellular capillaries. Western blotting analysis of retinal tissue showed increased inflammatory and necroptotic markers with A1 deletion. In vitro experiments showed that macrophages lacking A1 exhibit increased inflammatory response upon LPS stimulation. PEG-A1 treatment dampened this inflammatory response and decreased the LPS-induced metabolic reprogramming. Moreover, intravitreal injection of A1 KO macrophages or systemic macrophage depletion with clodronate liposomes increased neuronal loss after IR injury. These results demonstrate that A1 reduces IR injury-induced retinal neurovascular degeneration via dampening macrophage inflammatory responses. Increasing A1 offers a novel strategy for limiting neurovascular injury and promoting macrophage-mediated repair.
Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible changes
Authors: Wärri Anni , Cook Katherine L. , Hu Rong , Jin Lu , Zwart Alan , Soto-Pantoja David R. , Liu Jie , Finkel Toren , Clarke Robert 
Published: September 2018

AbstractThe postnatal mammary gland undergoes repeated cycles of proliferation and cell death, most notably when the fully differentiated (lactating) gland dedifferentiates to a prelactation state. Accumulation of milk proteins in the secretory epithelium creates the stress signal that triggers this process (involution). How this stress is perceived, and the cellular processes that are subsequently activated, remain unclear. We now report that Unfolded Protein Response (UPR), autophagy, and apoptosis related genes cluster separately during lactation and involution in the mouse mammary gland. Time-course experiments in rodents show that autophagy and UPR signaling are tightly co-regulated at the transition from reversible to irreversible involution. Inhibition of autophagy by chloroquine or genetic deletion of one ATG7 allele enhanced progression of mammary involution into the irreversible phase, as characterized by an early/precocious induction of apoptosis. These are the first preclinical in vivo data in support of a clinical trial testing an autophagy inhibitor for prevention of intraductal breast malignancy progression to invasive breast cancer. In marked contrast, stimulation of autophagy by low dose tunicamycin treatment reduced apoptosis and extended the reversible phase of involution by sustaining the secretory epithelium. Autophagy stimulators could be used short-term to promote lactation in women experiencing difficulties or irregularities in nursing. Taken together, these data indicate that UPR and autophagy play a key role in regulating the balance between cell survival and apoptosis during normal mammary gland regression.
Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
Authors: Robert-Paganin Julien , Auguin Daniel , Houdusse Anne 
Published: September 2018

AbstractHypertrophic cardiomyopathies (HCM) result from distinct single-point mutations in sarcomeric proteins that lead to muscle hypercontractility. While different models account for a pathological increase in the power output, clear understanding of the molecular basis of dysfunction in HCM is the mandatory next step to improve current treatments. Here, we present an optimized quasi-atomic model of the sequestered state of cardiac myosin coupled to X-ray crystallography and in silico analysis of the mechanical compliance of the lever arm, allowing the systematic study of a large set of HCM mutations and the definition of different mutation classes based on their effects on lever arm compliance, sequestered state stability, and motor functions. The present work reconciles previous models and explains how distinct HCM mutations can have disparate effects on the motor mechano-chemical parameters and yet lead to the same disease. The framework presented here can guide future investigations aiming at finding HCM treatments.
Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies
Authors: Madelain Vincent , Baize Sylvain , Jacquot Frédéric , Reynard Stéphanie , Fizet Alexandra , Barron Stephane , Solas Caroline , Lacarelle Bruno , Carbonnelle Caroline , Mentré France , Raoul Hervé , de Lamballerie Xavier , Guedj Jérémie 
Published: September 2018

AbstractDespite several clinical trials implemented, no antiviral drug could demonstrate efficacy against Ebola virus. In non-human primates, early initiation of polymerase inhibitors favipiravir and remdesivir improves survival, but whether they could be effective in patients is unknown. Here we analyze the impact of antiviral therapy by using a mathematical model that integrates virological and immunological data of 44 cynomolgus macaques, left untreated or treated with favipiravir. We estimate that favipiravir has a ~50% efficacy in blocking viral production, which results in reducing virus growth and cytokine storm while IFNα reduces cell susceptibility to infection. Simulating the effect of delayed initiations of treatment, our model predicts survival rates of 60% for favipiravir and 100% for remdesivir when treatment is initiated within 3 and 4 days post infection, respectively. These results improve the understanding of Ebola immuno-pathogenesis and can help optimize antiviral evaluation in future outbreaks.
Efficient photocatalytic hydrogen evolution with ligand engineered all-inorganic InP and InP/ZnS colloidal quantum dots
Authors: Yu Shan , Fan Xiang-Bing , Wang Xian , Li Jingguo , Zhang Qian , Xia Andong , Wei Shiqian , Wu Li-Zhu , Zhou Ying , Patzke Greta R. 
Published: September 2018

AbstractPhotocatalytic hydrogen evolution is a promising technique for the direct conversion of solar energy into chemical fuels. Colloidal quantum dots with tunable band gap and versatile surface properties remain among the most prominent targets in photocatalysis despite their frequent toxicity, which is detrimental for environmentally friendly technological implementations. In the present work, all-inorganic sulfide-capped InP and InP/ZnS quantum dots are introduced as competitive and far less toxic alternatives for photocatalytic hydrogen evolution in aqueous solution, reaching turnover numbers up to 128,000 based on quantum dots with a maximum internal quantum yield of 31%. In addition to the favorable band gap of InP quantum dots, in-depth studies show that the high efficiency also arises from successful ligand engineering with sulfide ions. Due to their small size and outstanding hole capture properties, sulfide ions effectively extract holes from quantum dots for exciton separation and decrease the physical and electrical barriers for charge transfer.
Pastoralism may have delayed the end of the green Sahara
Authors: Brierley Chris , Manning Katie , Maslin Mark 
Published: September 2018

AbstractThe climate deterioration after the most recent African humid period (AHP) is a notable past example of desertification. Evidence points to a human population expansion in northern Africa prior to this, associated with the introduction of pastoralism. Here we consider the role, if any, of this population on the subsequent ecological collapse. Using a climate-vegetation model, we estimate the natural length of the most recent AHP. The model indicates that the system was most susceptible to collapse between 7 and 6 ka; at least 500 years before the observed collapse. This suggests that the inclusion of increasing elements of pastoralism was an effective adaptation to the regional environmental changes. Pastoralism also appears to have slowed the deterioration caused by orbitally-driven climate change. This supports the view that modern pastoralism is not only sustainable, but beneficial for the management of the world’s dryland environments.
Carrier density and disorder tuned superconductor-metal transition in a two-dimensional electron system
Authors: Chen Zhuoyu , Swartz Adrian G. , Yoon Hyeok , Inoue Hisashi , Merz Tyler A. , Lu Di , Xie Yanwu , Yuan Hongtao , Hikita Yasuyuki , Raghu Srinivas , Hwang Harold Y. 
Published: September 2018

AbstractQuantum ground states that arise at atomically controlled oxide interfaces provide an opportunity to address key questions in condensed matter physics, including the nature of two-dimensional metallic behaviour often observed adjacent to superconductivity. At the superconducting LaAlO3/SrTiO3 interface, a metallic ground state emerges upon the collapse of superconductivity with field-effect gating and is accompanied with a pseudogap. Here we utilize independent control of carrier density and disorder of the interfacial superconductor using dual electrostatic gates, which enables the comprehensive examination of the electronic phase diagram approaching zero temperature. We find that the pseudogap corresponds to precursor pairing, and the onset of long-range phase coherence forms a two-dimensional superconducting dome as a function of the dual-gate voltages. The gate-tuned superconductor–metal transitions are driven by macroscopic phase fluctuations of Josephson coupled superconducting puddles.
Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells
Authors: Romero Maria Montserrat Garcia , McCathie Gareth , Jankun Philip , Roehl Henry Hamilton 
Published: September 2018

AbstractMany aquatic vertebrates have a remarkable ability to regenerate limbs and tails after amputation. Previous studies indicate that reactive oxygen species (ROS) signalling initiates regeneration, but the mechanism by which this takes place is poorly understood. Developmental signalling pathways have been shown to have proregenerative roles in many systems. However, whether these are playing roles that are specific to regeneration, or are simply recapitulating their developmental functions is unclear. Here, we analyse zebrafish larval tail regeneration and find evidence that ROS released upon wounding cause repositioning of notochord cells to the damage site. These cells secrete Hedgehog ligands that are required for regeneration. Hedgehog signalling is not required for normal tail development suggesting that it has a regeneration-specific role. Our results provide a model for how ROS initiate tail regeneration, and indicate that developmental signalling pathways can play regenerative functions that are not directly related to their developmental roles.