bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kontribusi Senam Lansia Dan Imt Terhadap Kebugaran Di Rpslu Pucang Gading Semarang Tahun 2017
Authors: Dasmiyanti Ratna Wiwi 
Published: April 2018

Tujuan penelitian ini adalah untuk mendeskripsikan hubungan senam lansia terhadap kebugaran lansia, IMT terhadap kebugaran, serta senam lansia dan IMT terhadap kebugaran lansia di RPSLU Pucang Gading Semarang Tahun 2017. Populasi dalam penelitian ini adalah lansia RPSLU Pucang Gading Semarang Tahun 2017. Sampel dalam penelitian ini adalah lansia bugar RPSLU Pucang Gading Semarang Tahun 2017 sebanyak 26 lansia. Teknik sampling yang digunakan adalah Purposive Sampling. Metode pengambilan data menggunakan metode survei korelasi dengan metode tes pengukuran DN, IMT, Test Rockport. Data dari hasil instrumen tes diolah dengan metode analisis korelasi product moment analisis regresi ganda dengan dua prediktor. Dari hasil analisis menunjukkan bahwa terdapat hubungan yang positif dari senam lansia terhadap kebugaran lansia dengan besar kontribusi 21,1%. Hubungan yang positif dan signifikan antara IMT terhadap kebugaran dengan besar kontribusi 19,8%. Secara bersama-sama memiliki hubungan yang positif dan signifikan antara senam lansia dan IMT terhadap kebugaran lansia dengan besar kontribusi 36,5%. Simpulan yang dapat diambil adalah dari tiga variabel yang diangkat dalam penelitian ini memiliki hubungan yang positif dan signifikan. Secara bersama-sama memberikan sumbangan sebesar 36,5%, sisanya dipengaruhi oleh faktor lain seperti usia, pola makan,dll.
USING SULFUR-CONTAINING MINERALS IN MEDICINE: IRANIAN TRADITIONAL DOCUMENTS AND MODERN PHARMACEUTICAL TERMINOLOGY
Authors: DARBANDI MAHBOOBEH PARVARESH , TAHERI JAFAR 
Published: April 2018

ABSTRACT
Sulfur occurs naturally in the earth's crust as a pure element (native sulfur), as well as sulfide and sulfate minerals. From the biochemical point of view, sulfur is a vital element because it is a constituent of enzymes and other key proteins. In addition to modern uses of minerals, in old Iranian documents of traditional medicine, attention was paid to physico-chemical properties of minerals and the various methods of administration. In this review, the traditional usage of sulfur and sulfide minerals (e.g. orpiment, realgar and stibnite) and sulfate minerals (e.g. alum, jarosite, epsomite and melanterite) as documented in the Canon of Medicine of Avicenna (also known as Ibn Sina) and the Zakhireh Kharazmshahi of Jorjani, is compared with new findings about the advantages and disadvantages of these minerals in medical geology.
The main conditions for the selection of mineral drugs was described first by Avicenna. There is a high correlation between old and modern pharmaceutical practices. The most important results concern the application of alum as a hemostatic agent (to inhibit hemorrhages), the use of jarosite as a method for treating osteoarthritis, the choice of melanterite for treating eczema, killing insects and as an anti-bacterial agent, the use of epsomite as an active ingredient in laxatives, homeostatics and mineral supplements, and the extensive use of sulfur in dermatology for its keratolytic effects and its supposed anti-microbial effects. In this review, newly developed pharmaceutical information about the use and effects on health of sulfide minerals will be compared to traditional pharmaceutical applications.
ÖĞRETMEN ADAYLARININ ÇOKKÜLTÜRLÜLÜĞE İLİŞKİN TUTUMLARI
Authors: Güngör Sabri , Buyruk Halil , Özdemir Yalçın 
Published: April 2018

Bu
araştırmada, öğretmen adaylarının çokkültürlülüğe yönelik tutumlarının bazı
değişkenlere göre incelenmesi amaçlanmıştır. Araştırmada tarama modeli
kullanılmıştır. Araştırmanın çalışma
grubu, 2015-2016 bahar yarıyılında Kafkas Üniversitesi Eğitim Fakültesinde
birinci sınıftan dördüncü sınıfa kadar öğrencisi bulunan Okul Öncesi
Öğretmenliği, Sınıf Öğretmenliği, Fen Bilgisi Öğretmenliği, Sosyal Bilgiler
Öğretmenliği ve Psikolojik Danışma ve Rehberlik programlarından oluşmaktadır.
Araştırma, ilgili programların tüm sınıflarındaki öğretmen adayları arasından
araştırmaya gönüllü olarak katılmak isteyenlerle gerçekleştirilmiştir.
Araştırmaya 292 öğretmen adayı katılmıştır. Araştırmada veri toplama aracı olarak Munroe
ve Pearson’un (2006) “Çokkültürlülük Tutum Ölçeği” kullanılmıştır. Araştırmaya
katılanların demografik özellikleri yüzde ve frekans ile yaş, bölge, program ve
sınıf grupları arasında anlamlı farklılığın olup olmadığı tek yönlü ANOVA Testi
ile analiz edilmiş, anlamlı farklılıklar LSD analizleri ile yapılmıştır.
Katılımcıların cinsiyetleri ve anadilleri arasında anlamlı farklılık olup
olmadığı bağımsız t-Testi ile analiz edilmiştir. Araştırma sonucunda öğretmen
adaylarının çokkültürlülük konusunda “yüksek” düzeyde olumlu tutuma sahip
olduğu belirlenmiştir. Öğretmen adaylarının çokkültürlülük tutumları, yaşlarına
ve öğrenim gördükleri sınıflara göre anlamlı farklılık göstermezken,
cinsiyetlerine, geldikleri bölgeye, programa ve anadillerine göre anlamlı
farklılıklar göstermektedir.
Perceived Activities and Participation Outcomes of a Yoga Intervention for Individuals with Parkinson's Disease: A Mixed Methods Study
Authors: Hawkins Brent L. , Van Puymbroeck Marieke , Walter Alysha , Sharp Julia , Woshkolup Kathleen , Urrea-Mendoza Enrique , Revilla Fredy , Schmid Arlene A. 
Published: April 2018

Abstract
Parkinson's disease (PD) often leads to poor balance, increased falls, and fear of falling, all of which can reduce participation in life activities. Yoga, which usually includes physical exercise, can improve functioning and life participation; however, limited research has been conducted on the effects of yoga on life participation of individuals with PD. This study had two purposes: (1) to identify and understand the perceived activities and participation outcomes associated a therapeutic yoga intervention for individuals with PD; and (2) to compare the perceived activities and participation outcomes with the outcomes measured in the clinical trial. A single-blind, randomized, waitlist-controlled, phase II exploratory pilot study using an after-trial embedded mixed methods design (clinical trial Pro00041068) evaluated the effect of an 8-week Hatha Yoga intervention on individuals with PD. Directed content analysis was used to analyze focus group interviews with participants who completed the yoga intervention. Quantitative and qualitative data were merged and compared using a data comparison matrix. Qualitative analysis indicated many activities and participation outcomes. Comparison of qualitative and quantitative data indicated the yoga intervention led to improved balance, mobility, and functional gait, and fewer falls. These outcomes reached beyond the intervention and into participants' daily lives. Results support the use of Hatha Yoga as a community-based rehabilitation intervention for individuals with PD. Yoga, as part of an interdisciplinary approach to treatment, can improve many types of activities and participation outcomes (e.g., mobility, social relationships, self-care, handling stress, recreation).
Informative value of biometric indices of iris, sclera and cornea in primary open-angle glaucoma diagnosis
Authors: Strakhov Vladimir V. , Alekseev Victor V. , Al-Mrrani Abdulgavi M. , Popova Anastasiya A. , Klimova Olga N. 
Published: April 2018

Aim: to study the thickness of cornea, iris and scleral tissue, to determine its asymmetry between fellow eyes in healthy subjects and in patients with primary glaucoma. To determine the relationship between changes in biomechanical properties of the cornea and sclera and iris thickness in healthy subjects and in patients with primary glaucoma.
Materials and methods. 10 patients (20 eyes) with primary glaucoma were examined. The control group consisted of 10 people (20 eyes). In all patients ultrasound biomicroscopy (Humphrey Instruments (USA), Model 840) was performed.
Results and discussion. The article presents a study of the corneoscleral and iris tissue thickness in primary glaucoma, as well as the increase pattern of the revealed asymmetry in corneoscleral and iris tissue thickness from normal state to glaucoma. A positive direct correlation between the indices of cornea, sclera, and iris thickness in the primary glaucoma group and between biometric parameters of sclera and iris and the of corneal hysteresis value in primary open-angle glaucoma.
Satisfacción laboral: una revisión de la literatura acerca de sus principales determinantes
Authors: Pujol-Cols Lucas J. , Dabos Guillermo E. 
Published: April 2018

Aun cuando el estudio de la satisfacción laboral ha concentrado un gran interés científico durante buena parte del último siglo, todavía resulta sorprendente cuan fragmentado se encuentra el campo y cuan limitados han sido los esfuerzos de integración. Este artículo se propone identificar los principales factores que han sido señalados en la literatura empírica como determinantes de la satisfacción laboral, a partir de una revisión de investigaciones publicadas en revistas científicas de alto impacto durante las últimas dos décadas. Los resultados revelan una insuficiencia de investigaciones que hayan estudiado de manera simultánea los efectos de determinantes disposicionales y situacionales sobre la satisfacción laboral. Finalmente, se analizan los principales vacíos existentes en la literatura y se sugieren líneas potenciales de investigación.
Opilación y supresión de menstruos: una receta médica del siglo XVIII en el Nuevo Reino de Granada
Authors: Vásquez Carvajal Carolina , Uribe-Vergara Jorge , Martínez-Lozano Julio César , Gómez-Gutiérrez Alberto , Briceño-Balcázar Ignacio 
Published: April 2018

Objetivo: Presentar y definir el contexto de una receta médica que data del siglo XVIII en el Nuevo Reino de Granada, utilizada para la supresión de la menstruación, así como analizar a la luz de los conocimientos actuales si sus ingredientes en conjunto podrían o no lograr la inhibición del sangrado menstrual.Metodología: Se realizó una búsqueda documental en el archivo histórico de la biblioteca Octavio Arizmendi Posada en la Universidad de la Sabana en la que se encuentra la receta “Opilacion y supresión de menstruos”, y posteriormente se condujo una revisión de la literatura disponible en las bases de datos SciELO/proQuest en el periodo 1993 - 2015. Conclusiones: En la receta manuscrita hallada en el archivo histórico de la Universidad de la Sabana se describen múltiples ingredientes que, analizados a la luz de los conocimientos actuales, y en su conjunto, no tienen validez para lograr el pretendido efecto supresor. Sin embargo, se reconocen las propiedades antianémicas del “vitriolo líquido de Marte” y el posible efecto que ejercería el ejercicio excesivo formulado en medio del ciclo menstrual, aunque en la receta no se describe con exactitud la frecuencia ni la intensidad con la que este debería ser realizado para lograr una supresión del menstruo.
Preoperative hemogram-related parameters to distinguish renal cell carcinoma from benign kidney masses: HERR score
Authors: TÜRKOĞLU Ali Rıza , ÜSTÜNDAĞ Yasemin 
Published: April 2018

Objectives: Renal cell carcinoma (RCC) accounts for approximately 90% of all kidney malignancies, and it is difficult to preoperatively distinguish between tumors and benign masses without a kidney biopsy in small renal masses. We investigated whether any preoperatively defined hemogram-related parameters had a predictive value that would distinguish RCC from benign kidney masses using a novel scoring method. Methods: Between January 2011 and November 2017, 330 patients diagnosed with kidney masses and who received an operation were included. Fifty-six masses were benign. The neutrophil-to-lymphocyte count (NLR), platelet-to-lymphocyte count, lymphocyte-to-monocyte count, mean platelet volume, platelet count ratio, and hemoglobin to red cell distribution width ratios were calculated. The hemogram-related parameters were combined with the tumor size to establish the hemogram-related risk (HERR) score. The area under the receiver operating characteristics curve, sensitivity, specificity, and likelihood ratios were evaluated to preoperatively diagnose RCC.Results: Histological findings confirmed RCC in 274 patients. The NLR [median (interquartile range)] was higher in patients with RCC, 3.7 (4.7), compared to a benign kidney mass, 2.4 (2.2) (p &lt; 0.001). A HERR score cut-off of ≥ 3 showed a good sensitivity at 78% with an LR+ of 10.8 [95% confidence interval (CI): 7.0-16.4] and an LR- of 1.2 (95% CI: 1.0-1.5). Conclusion: Our study, despite being a preliminary validation, is the first to evaluate hemogram-related parameters for preoperatively discriminating between RCC and benign renal masses, and the HERR score serves as a potential diagnostic biomarker for this.
Differential proteome analysis of pea roots at the early stages of symbiosis with nodule bacteria
Authors: Leppyanen I. V. , Kirienko A. N. , Lobov A. A. , Dolgikh E. A. 
Published: April 2018

In this paper, we have analyzed changes in the proteomic spectrum of pea Pisum sativum L. roots during inoculation with rhizobial bacteria with the aim of revealing new regulators of symbiosis development. To study the changes in the proteome spectrum of pea roots, a differential twodimensional (2-D) electrophoresis was performed using fluorescent labels Cy2 and Cy5. The images obtained made it possible to identify differences between the control variant (uninoculated roots) and the root variant after inoculation with Rhizobium leguminosarum bv. viciae RCAM 1026 (24 hours after treatment). 20 proteins were revealed and identified, the synthesis of which was enhanced during the inoculation of pea roots by nodule bacteria. To identify the proteins, a mass spectrometric analysis of tryptic peptides was performed on a quadrupole-time-of-flight mass spectrometer combined with a high-performance liquid chromatograph. Among such proteins, the beta-subunit of the G protein and the disulfide isomerase/phospholipase C were first found, whose function can be related to the signal regulation of symbiosis. This indicates that G-proteins and phospholipases can play a key role in the development of early stages of symbiosis in peas. Further experiments are expected to show whether the beta-subunit of the G protein interacts with the receptors to Nod factors, and how this affects the further signaling. Other proteins that might be interesting were annexin D8 and D1, protein kinase interacting with calcinerin B, actin-binding protein profilin, GTP-binding protein Ran1. They may be involved in the regulation of reactions with calcium, the reorganization of the actin cytoskeleton and other important processes in plants. The study of the role of such regulatory proteins will later become the basis for understanding the complex system of signal regulation, which is activated in pea plants by interaction with nodule bacteria.
Genetic polymorphism of CYP1A1 and CYP2D6 in populations of Buryats, Teleuts and Russians of Eastern Siberia
Authors: Tabikhanova L. E. , Osipova L. P. , Churkina T. V. , Voronina E. N. , Filipenko M. L. 
Published: April 2018

The study of the gene polymorphism of the system of biotransformation of xenobiotics is an important area of modern medical and genetic research. The aim of this work is to study the frequency of the alleles of the CYP1A1 (A2455G (*2C), rs1048943), CYP2D6 (A2549del (*3), rs35742686); G1846A (*4), rs3892097) genes of Teleuts (n = 115), Eastern Buryats (n = 132), Western Buryats (n = 280), their Métis (n = 56), and Russians of East Siberia (n = 122). Genotyping was performed using real-time PCR with competitive TaqMan allele-specific probes. The frequency of the CYP1A1*2C (2455G) allele was 28.8 % in the Eastern Buryat, 34.6 % in the Western Buryat, 16.7 % in the Teleut, and 31.3 % in the Métis cohort. The frequency of CYP1A1*2C (2455G) in the Russians of Eastern Siberia (4.1 %) corresponds to the frequency range found in European populations. A high-frequency occurrence of CYP1A1*2C (2455G) among Buryats and Teleuts may be indicative of a higher population-wide risk of diseases influenced by technogenic pollutants – substrates of CYP1A1. The CYP2D6*3 (2549del) allele was not detected in cohorts of indigenous populations, among Russians it was 0.4 %, and it was 2.7 % among Métis. The frequency of CYP2D6*4 (1846A) in Eastern and Western Buryats was 5.3 % and 4.3 %, respectively, for Teleuts it was 7.4 %. It was significantly higher in the Russian population (12 %), and among Métis (9.8 %). The obtained data makes it possible to predict a reduced risk of side effects of drugs and cancer associated with CYP2D6*3 (2549del) and CYP2D6*4 (1846A) in the Buryat and Teleut populations. However, metisation introduces new polymorphic variants into indigenous populations, shifts gene frequencies and changes the degree of risks.
Tissue-specific effects of benzo[a]pyrene and DDT on microRNA expression profile in female rats
Authors: Ushakov D. S. , Kalinina T. S. , Dorozhkova A. S. , Ovchinnikov V. Y. , Gulyaeva L. F. 
Published: April 2018

Many xenobiotics in the human environment, such as benzo[a]pyrene (B(a)P) and dichlorodiphenyltrichloroethane (DDT), may act as non-genotoxic carcinogens through epigenetic mechanisms, including changes in microRNA expression profile. In part, such disorders can be mediated by the activation of nuclear receptors, resulting in the activation of protein coding gene expression and microRNAs involved in malignant transformation of cells. Therefore, the aim of this study was to investigate the chain of events “xenobiotic administration – receptor activation – up-regulating microRNA expression – down-regulation target genes expression” as one of the key factors in the chemically-induced carcinogenesis. Using in silico methods, an analysis of the rat genome was carried out to find microRNAs putatively regulated by AhR (aryl hydrocarbon receptor) and CAR (constitutive androstane receptor), activated by BP and DDT, respectively. In particular, miR-3577 and -193b were selected as potentially regulated CAR, miR-207 was selected as a candidate for miR under AhR regulation. The results of the study showed that the treatment of female rats with DDT and B(a)P caused a tissue-specific changes in the expression of microRNAs and host genes in both acute and chronic administration of xenobiotics. To confirm the effects of xenobiotics on the microRNA expression, we also estimated the mRNA level of PTPN6, EIF3F, Cbx7, and Dicer1 genes potentially targeting miR-193b, -207, and -3577. The study has shown a high correlation between the expression of target genes and microRNAs; however these changes depended on the tissue types, the dose and time after xenobiotic treatment.
Changing of expression actinbinding proteins in the kidney under dehydration
Authors: Khegay I. I. 
Published: April 2018

Actin is related to main structural proteins in eukaryotes. In opposite to muscle alpha-actin, beta-actin is expressing in all types of cells. The constant reorganization of actin cytoskeleton takes place in non-muscle cells. Fibrillar actin, organized by globular monomers, interacts with the actin-binding proteins. Alpha-actinin forms a transverse links in actin fibrillar network, as well as concentrates in the fields of focal contacts. Tropomyosin is related to regulatory components of beta-actin, and due to the expense of longitudinal localization of the molecule in the groove of actin microfilament, stereochemically shields the sites of other actin-binding proteins. The most important function of actin cytoskeleton is the participation in the transportation of vesicles with aquaporins of second type in principal cells of an epithelium of collecting ducts in renal medulla. Vasopressin is stimulating the release of aquaporin tetramers from cytoplasmic store to apical plasmatic membrane. The participation and role of separate cytoskeleton proteins in the process of aquaporin trafficking and forming additional pores for water stays a poorly studied place in the molecular physiology of kidney. We explored the osmoregulatory action of prolonged hydration and dehydration on the protein composition of actin cytoskeleton in rats depending on the presence or absence of the actively expressing vasopressin gene in the genome. We found that the efficiency of the renal concentrating system, controlled by vasopressin, depends on expression of actin-binding proteins in the renal medulla. On the background of a stable level of inner cellular beta-actin, a change of expression an alpha-actinin and tropomyosin is observed. Dehydration of the organism is accompanied by essential reducing of alpha-actinin. In the absence of vasopressin, reduction of alpha-actinin has a smaller amplitude. The presence of the normal vasopressin gene in the genome, regardless of transitory expression level and secretion of hormone, is a factor of lower tropomyosin in the kidney. The most probable molecular mechanism of changing the expression of the genes for alpha-actinin and tropomyosin is transduction of the V2-mediated vasopressin hormonal signal to protein kinase A, phosphorylation of the cAMPresponsible transcriptional factor CREB, and nuclear CREB interaction with gene CRE sites sensitive to it.
Homologs of the rolC gene of naturally transgenic toadflaxes Linaria vulgaris and Linaria creticola are expressed in vitro
Authors: Matveeva T. V. , Bogomaz O. D. , Golovanova L. A. , Li Yu. S. , Dimitrov D. 
Published: April 2018

Agrobacterium mediated transformation is the most common way for obtaining transgenic plants in laboratory conditions. At the same time, there are species inside the genera Nicotiana, Linaria and Ipomoea that contain homologs of agrobacterial T-DNA genes as a result of genetic transformation of their ancestral forms in natural conditions. Such plants are called naturally transgenic plants, and T-DNA in their genomes is called cellular (cT-DNA). It is proposed that in the evolution of these genera, the introduced sequences played an important role. This idea is confirmed by the data on the expression of some T-DNA genes in Nicotiana and Ipomoea. Until the last moment, the expression of cT-DNA genes in Linaria has not been documented. However, the analysis of the nucleotide sequence indicates the functionality of rolC gene in L. vulgaris Mill., L. acutiloba Fisch. ex Rchb., L. genistifolia (L.) Mill. In this research work, we have sequenced the rolC homolog in one more toadflax species (Linaria creticola Kuprian). The in silico analysis of this gene has shown that it can encode a full-length peptide. Using the real time RT-PCR method, we have demonstrated that the rolC homolog is expressed in vitro in shoots, roots and calli of L. vulgaris Mill., as well as in shoots of L. creticola Kuprian. The results obtained are an important argument in favor of the fact that cT-DNA is functional and that its fixation in genomes played a certain role in the evolutionary process. However, the level of expression of the gene studied is quite low. A similar trend was observed in other naturally transgenic species. This can explain the absence of explicit morphological differences of species containing cT-DNA from their non-transgenic relatives.