bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjustment to amputation and interest in upper limb transplantation
Authors: Talbot Simon G , Carty Matthew J , Jensen Sally E , Dumanian Gregory A 
Published: June 2019

Objective: Upper limb transplantation provides a new restorative option for individuals with amputations. As true for most operations, patient selection is critical to optimizing transplantation outcomes. To improve on the patient selection process, we used qualitative methods to better understand the issues regarding upper extremity loss as well as upper limb transplantation from the amputee point of view. Methods: Individuals with upper limb amputations (age range = 24–73 years) discussed their adjustment following amputation and their interest toward transplantation in either a focus group (n = 5) or semi-structured interview (n = 17). Transcripts were coded by theme and summarized. Results: Participants described a year-long process typified by adjustment to a new role as an amputee, both psychosocially and functionally. We found that the extent of adjustment was inversely related to an interest in transplantation. Conclusions: These findings could explain the difficulty in identifying “ideal” candidates for upper extremity transplantation and may have implications for patient selection and counseling. Level of Evidence: Prognostic Study, Level V
Foundation Year 1 doctors’ experience and confidence in catheterisation: A multicentre survey
Authors: Grimes NG , Leask J , McKay AC , McIlhenny C 
Published: June 2019

Objective: This survey sought to review the experience gained by doctors during their first year of training and their confidence in performing this procedure. Materials and methods: All Foundation Year 1 doctors in three hospitals in Scotland were invited to complete an online survey towards the end of their first year of training. The survey asked participants about the number of catheterisations performed, confidence with this procedure and whether they had been signed off as competent. Results: In total, 149 doctors were invited to complete the questionnaire and 98 (65.8%) responded. At the time of survey completion, 97.9% and 93.6% of respondents were signed off as competent for male and female catheterisation respectively. A total of 55.7% had performed fewer than five catheterisations, 28.9% had performed 5–10 and 15.5% had performed more than 10. We found 25.8% were very confident about performing an average-difficulty catheterisation and 6.3% were very confident about performing an above-average difficulty catheterisation. Overall, 7.1% of respondents were very confident about changing a suprapubic catheter. Conclusion: Despite being deemed competent by the end of first year of training and meeting curriculum requirements, confidence levels in performing catheterisation remains low and many doctors do not have sufficient experience and confidence for daily practice. Level of evidence: 2c
Candida albicans cholecystitis with associated hepatitis in a cat
Authors: Palermo Shannon M , Newman Ashleigh W , Koch Michael W 
Published: June 2019

Case summary A 3-year-old male neutered domestic shorthair cat was presented for vomiting, inappetence and icterus. Biochemical results and ultrasonographic findings were consistent with cholestasis and possible biliary obstruction. A diagnosis of Candida albicans cholecystitis with associated hepatitis was made following cytologic examination and fungal culture. Progressive hyperbilirubinemia and hepatic encephalopathy were ultimately fatal. Relevance and novel information To our knowledge, this is the first report of biliary candidiasis diagnosed by cytologic examination of a cholecystocentesis sample in a domestic animal with no evidence of immunodeficiency. Additionally, this is the first reported case of fungal cholecystitis with associated white bile syndrome due to obstructive cholestasis, without an overt gall bladder mucocele.
Improvements in Psychological and Occupational Well-being Following a Brief Yoga-Based Program for Education Professionals
Authors: Trent Natalie L , Borden Sara , Miraglia Mindy , Pasalis Edi , Dusek Jeffery A , Khalsa Sat Bir S 
Published: June 2019

Objective The purpose of this study was to examine changes in psychological and occupational well-being in education professionals who attended a yoga-based program. Methods Education professionals who attended a 3-day yoga-based RISE (resilience, integration, self-awareness, engagement) program were recruited to participate. RISE was administered at the Kripalu Center for Yoga & Health. Measures of psychological and occupational well-being, and health-related behaviors were completed before (baseline), after (post), and 2 months after RISE (follow-up). Forty-four participants completed baseline and post and were included in the analysis. Of those, 33 participants also completed the follow-up. Paired samples t tests were used to compare scores between time points. Results Compared to baseline, at post, participants showed improvements in perceived stress, mindfulness, empowerment, positive affect, negative affect, self-compassion, total work engagement, vigor, sleep quality (all P values < .001), resilience, satisfaction with life, as well as exhaustion and professional efficacy which are dimensions of burnout (all P values < .01). At the follow-up, significant improvements were maintained for mindfulness, empowerment, self-compassion, sleep quality (all P values < .001), resilience, vigor, and exhaustion (all P values < .01) and positive affect, satisfaction with life, and work engagement (all P values < .05). Conclusions These findings suggest that the yoga-based RISE program improves psychological and occupational well-being in education professionals. In addition, participants reported that attending RISE was feasible, they could continue using RISE practices long-term, shared them with work colleagues, and reported that RISE positively impacted both their daily lives and workplace environment. With these promising results, additional controlled research is warranted.
Outcomes Following Treatment of the Infected Achilles Tendon
Authors: Bowers Mark W. , Turner Norman S. , Ryssman Daniel B. , Moran Steven L. 
Published: June 2019

Background: Infection following Achilles tendon surgery is a devastating complication and can be difficult to treat and often leads to poor outcomes. A number of treatments have been described, but there is little information concerning outcomes of these treatments. Our purpose was to evaluate the clinical and functional outcomes of patients who have undergone treatment for an infected Achilles tendon after acute and chronic midsubstance repair. Methods: We retrospectively reviewed the medical records of 20 patients who had undergone surgical treatment for an infected Achilles tendon between 2000 and 2016. The mean follow-up time was 21 months (range, 2-68 months). All patients underwent extensive debridement of the tendon with removal of all infected tissue and foreign material. Soft tissue wound coverage was utilized for large wounds that were not amenable to primary or secondary closure. All patients received culture-specific intravenous (IV) antibiotics for 3 to 6 weeks. Postoperatively, the extremity was immobilized in a splint followed by a cast until the wound was healed. The cast was then replaced with a walking boot and the patients were provided a physical therapy program. Functional outcomes were measured using the Foot and Ankle Ability Measure (FAAM) Activity of Daily Living (ADL) scale. Results: All wounds had healed at the time of last follow-up. Three patients (15%) required an unplanned return to the operating room for repeat debridement. All patients were able to walk without the use of a gait aid. Five patients (25%) required continued use of a boot or brace during ambulation. Fourteen patients participated in the FAAM ADL survey. There were 6 patients lost to follow-up. The average FAAM score was 87 (range, 71.4-100). At last follow-up, most patients reported their overall function as “normal” or “nearly normal.” Eradication of infection and satisfactory functional results can be attained after radical debridement, wound closure, and administration of culture-specific IV antibiotics. Level of Evidence: Level IV, retrospective case series.
Presalt reservoirs of the Santos Basin: Cyclicity, electrofacies, and tectonic-sedimentary evolution
Authors: Neves Igor de Andrade , Lupinacci Wagner Moreira , Ferreira Danilo Jotta Ariza , Zambrini João Paulo Rodrigues , Oliveira Luís Otávio Aguiar , Olho Azul Maria , Ferrari André Luiz , Gamboa Luiz Antonio Pierantoni 
Published: June 2019

Presalt reservoirs of the Santos Basin accounted for more than 50% of Brazilian hydrocarbon production in the first two months of 2019. Its most important reservoirs are found in the Barra Velha Formation; thus understanding its genesis and geologic history is essential. This formation is composed of carbonates deposited in an alkaline lacustrine environment with a multiplicity of facies from boundstones and grainstones to mudstones. We have performed a sedimentary analysis based on the integration of sidewall core (SWC) samples and well logs from two wells coupled with seismic patterns discrimination to characterize the tectonic and depositional evolution of the Barra Velha Formation in a sector of the Outer High of the Santos Basin in this study. Our method initially consisted of the evaluation of well logs, aiming to identify shallowing and flooding upward cycles of the second and third orders for the paleoenvironmental conceptualization upper rift and sag phases. Then, we defined electrofacies through the integration of SWCs, gamma ray, and acoustic impedance logs using the crossplot approach. Finally, we described seismic patterns throughout the study area and correlated with results from well data analysis. Therefore, the Barra Velha Formation was subdivided into three zones: the lower, intermediate, and upper zones. Well 1 has a facies association characteristic of a proximal and stable environment during deposition, whereas well 2 initially presents in a distal environment sedimentation that evolves to a more proximal setting. This fact evidenced differences with respect to base-level variations indicating compartmentalization within the lacustrine environment of the upper rift and sag phase that corroborated with the detailed seismic pattern interpretation of the study area.
Prospective Study of Cardiac Events During Proteasome Inhibitor Therapy for Relapsed Multiple Myeloma
Authors: Cornell Robert F. , Ky Bonnie , Weiss Brendan M. , Dahm Cherie N. , Gupta Deepak K. , Du Liping , Carver Joseph R. , Cohen Adam D. , Engelhardt Brian G. , Garfall Alfred L. , Goodman Stacey A. , Harrell Shelton Lacy , Kassim Adetola A. , Jadhav Trafina , Jagasia Madan , Moslehi Javid , O’Quinn Rupal , Savona Michael R. , Slosky David , Smith Amanda , Stadtmauer Edward A. , Vogl Dan T. , Waxman Adam , Lenihan Daniel 
Published: June 2019

PURPOSE Cardiovascular adverse events (CVAEs) can occur during proteasome inhibitor (PI) therapy. We conducted a prospective, observational, multi-institutional study to define risk factors and outcomes in patients with multiple myeloma (MM) receiving PIs. PATIENTS AND METHODS Patients with relapsed MM initiating carfilzomib- or bortezomib-based therapy underwent baseline assessments and repeated assessments at regular intervals over 6 months, including cardiac biomarkers (troponin I or T, brain natriuretic peptide [BNP], and N-terminal proBNP), ECG, and echocardiography. Monitoring occurred over 18 months for development of CVAEs. RESULTS Of 95 patients enrolled, 65 received carfilzomib and 30 received bortezomib, with median 25 months of follow-up. Sixty-four CVAEs occurred, with 55% grade 3 or greater in severity. CVAEs occurred in 51% of patients treated with carfilzomib and 17% of those treated with bortezomib ( P = .002). Median time to first CVAE from treatment start was 31 days, and 86% occurred within the first 3 months. Patients receiving carfilzomib-based therapy with a baseline elevated BNP level higher than 100 pg/mL or N-terminal proBNP level higher than 125 pg/mL had increased risk for CVAE (odds ratio, 10.8; P < .001). Elevated natriuretic peptides occurring mid–first cycle of treatment with carfilzomib were associated with a substantially higher risk of CVAEs (odds ratio, 36.0; P < .001). Patients who experienced a CVAE had inferior progression-free survival (log-rank P = .01) and overall survival (log-rank P < .001). PI therapy was safely resumed in 89% of patients, although 41% required chemotherapy modifications. CONCLUSION CVAEs are common during PI therapy for relapsed MM, especially with carfilzomib, particularly within the first 3 months of therapy. CVAEs were associated with worse overall outcomes, but usually, discontinuation of therapy was not required. Natriuretic peptides were highly predictive of CVAEs; however, validation of this finding is necessary before uniform incorporation into the routine management of patients receiving carfilzomib.
Evaluation of Commercial Circulating Tumor DNA Test in Metastatic Prostate Cancer
Authors: Taavitsainen Sinja , Annala Matti , Ledet Elisa , Beja Kevin , Miller Patrick J. , Moses Marcus , Nykter Matti , Chi Kim N. , Sartor Oliver , Wyatt Alexander W. 
Published: June 2019

PURPOSE Circulating tumor DNA (ctDNA) sequencing provides a minimally invasive method for tumor molecular stratification. Commercial ctDNA sequencing is increasingly used in the clinic, but its accuracy in metastatic prostate cancer is untested. We compared the commercial Guardant360 ctDNA test against an academic sequencing approach for profiling metastatic prostate cancer. PATIENTS AND METHODS Plasma cell-free DNA was collected between September 2016 and April 2018 from 24 patients with clinically progressive metastatic prostate cancer representing a range of clinical scenarios. Each sample was analyzed using Guardant360 and a research panel encompassing 73 prostate cancer genes. Concordance of somatic mutation and copy number calls was evaluated between the two approaches. RESULTS Targeted sequencing independently confirmed 94% of somatic mutations identified by Guardant360 at an allele fraction greater than 1%. AR amplifications and mutations were detected with high concordance in 14 patients, with only three discordant subclonal mutations at an allele fraction lower than 0.5%. Many somatic mutations identified by Guardant360 at an allele fraction lower than 1% seemed to represent subclonal passenger events or non–prostate-derived clones. Most of the non- AR gene amplifications reported by Guardant360 represented single copy gains. The research approach detected several clinically relevant DNA repair gene alterations not reported by Guardant360, including four germline truncating BRCA2/ ATM mutations, two somatic ATM stop gain mutations, one BRCA2 biallelic deletion, 11 BRCA2 stop gain reversal mutations in a patient treated with olaparib, and a hypermutator phenotype in a patient sample with 42 mutations per megabase. CONCLUSION Guardant360 accurately identifies somatic ctDNA mutations in patients with metastatic prostate cancer, but low allele frequency mutations should be interpreted with caution. Test utility in metastatic prostate cancer is currently limited by the lack of reporting on actionable deletions, rearrangements, and germline mutations.
Removal of Cationic or Anionic Dyes from Water Using Ion Exchange Cellulose Monoliths as Adsorbents
Authors: Yang Zhaohang , Asoh Taka-Aki , Uyama Hiroshi 
Published: June 2019

Abstract
This work deals with the preparation of poly(sodium p-styrenesulfonate) (PSS) and poly[(3-acryloylaminopropyl)trimethylammonium chloride] (APTAC) modified ion exchange cellulose monoliths (C-g-PSS and C-g-APTAC, respectively). The obtained ion exchange monoliths were employed for the removal of cationic or anionic dyes from aqueous solutions with particular reference to the effects of initial dye concentration, flow rate and ionic strength on adsorption. Detailed adsorption characteristics of ion exchange monoliths including operational parameters, adsorption kinetics and adsorption isotherms were investigated. Results showed exceptional affinity for adsorption of dyes due to the charge-induced adsorption. The observations from dynamic adsorption experiments indicated that the modified monoliths allowed ultra-fast adsorption of dyes at relatively high flow rates and were more favourable under low ionic strength conditions. An ultrahigh equilibrium adsorption capacity of 606.3 mg g−1 and dye removal efficiency of 72.3% for methylene blue was observed for the C-g-PSS monolith, which exhibited better adsorption performance than that of APTAC functionalized monolith for acid red 70. However, C-g-APTAC monolith was found superior in dye recoveries and regeneration, the adsorption efficiency can be maintained at 97% after 7 adsorption-desorption cycles. Combining the ultrafast adsorption kinetics with high removal capacity and good recyclability, the ion exchange monoliths have great potential for effluent treatment applications.
Quantitative evaluation of artefact reduction from metallic dental materials in short tau inversion recovery imaging: efficacy of syngo WARP at 3.0 tesla
Authors: Tran Lan Thi Xuan , Sakamoto Junichiro , Kuribayashi Ami , Watanabe Hiroshi , Tomisato Hiroshi , Kurabayashi Tohru 
Published: June 2019

Objectives: To evaluate the effects of syngo WARP on reducing metal artefacts from dental materials. Methods: Short tau inversion recovery (STIR) with syngo WARP [a dedicated metal artefact reduction sequence in combination with view-angle-tilting (VAT)] was performed using phantoms of three dental alloys: cobalt–chromium (Co–Cr), nickel–chromium (Ni–Cr), and titanium (Ti). Artefact volumes and reduction ratios of black, white and overall artefacts in the standard STIR and syngo WARP images with several different parameter settings were quantified according to standards of the American Society for Testing and Materials F2119-07. In all sequences, the artefact volumes and reduction ratios were compared. The modulation transfer function (MTF) and contrast-to-noise ratio (CNR) were also measured for evaluation of image quality. Results: In standard STIR, the overall artefact volume of Co–Cr was markedly larger than those of Ni–Cr and Ti. All types of artefacts tended to be reduced with increasing receiver bandwidth (rBW) and VAT. The effect of artefact reduction tended to be more obvious in the axial plane than in the sagittal plane. Compared with standard STIR, syngo WARP with a matrix of 384 × 384, receiver bandwidth of 620 Hz/pixel, and VAT of 100 % in the axial plane obtained reduction effects of 30 % (white artefacts), 45 % (black artefacts), and 38 % (overall artefacts) although MTF and CNR decreased by 30 and 22 % compared with those of standard STIR, respectively. Conclusions: syngo WARP for STIR can effectively reduce metal artefacts from dental materials.
Versatility of high resolution ultrasonography in the assessment of granulomas and radicular cysts: a comparative in vivo study
Authors: Sönmez Gül , Kamburoğlu Kıvanç , Yılmaz Funda , Koç Cemre , Barış Emre , Tüzüner Ayşegül 
Published: June 2019

Objectives:To evaluate and compare the diagnostic potential of high resolution ultrasound with periapical radiographs (PR) and CBCT in assessing granulomas and radicular cysts.Methods:This study included a total of 33 teeth from 33 patients with periapical lesions. Subjects were distributed among three groups. A consisted of teeth that were extracted. B consisted of teeth treated with root-canal treatment followed by apical surgery. C consisted of teeth treated with root-canal treatment only. Pre-treatment PR, ultrasound and CBCT images were obtained for Groups A, B and C and 6 month post-treatment PR and ultrasound images were obtained for Groups B and C. In addition, histopathological analysis was performed on lesions in Groups A and B. Lesions were classified as either cystic lesions or granulomas. Width, height, depth, surface area and volume of lesions were measured using the built-in softwares of the appropriate imaging modalities. Measurements were compared by Wilcoxon and paired sample t tests. Ultrasound and histopathological findings were compared with κ and Mc Nemar. Statistical significance was set at p < 0.05.Results:κ coefficient (0.667; p = 0.002) suggested good agreement between ultrasound and histopathology. No statistically significant differences were found among periapical radiography, CBCT and ultrasound in the pre-treatment measurements of lesion width ( p = 0.308) or between CBCT and periapical radiography in the pre-treatment measurements of lesion height ( p = 0.863). In all cases, mean measurement values for all variables were lower for ultrasound than for CBCT.Conclusion:Ultrasound provided useful information for the diagnosis and assessment of granulomas and radicular cysts.
Editorial
Authors: Kelly Erin E. , Gough Melinda J. , Ostovich Helen , Johnson Sarah 
Published: June 2019

The editorial for issue 22.1 acknowledges that Early Theatre has received a SSHRC Aid to Scholarly Journals grant; announces an Issues in Review section on disability and early modern drama planned for issue 22.2; thanks Peter Kirwan for serving as our Book Reviews editor since 2013; and declares that Georgina Lucas will become our new Book Reviews editor.
Barriers to nurses reporting errors and adverse events
Authors: Mansouri Seyedeh Fereshteh , Mohammadi Tahereh Khaleghdoost , Adib Masoomeh , Lili Ehsan Kazemnejad , Soodmand Mostafa 
Published: June 2019

Aim: this study aimed to assess nurses' views about major barriers to reporting errors and adverse events in intensive care units. Method: a descriptive analytical study was used to examine barriers to reporting such events. A questionnaire was completed by 251 nurses across seven hospitals in Iran to elicit information about their views on reporting errors and adverse events. Results: the study identified three main areas that prevented the reporting of incidents—fear of the consequences after reporting an error, procedural barriers and management barriers. Conclusion: the most important approach to overcoming barriers that prevent nurses reporting adverse events would be to develop an atmosphere within which all nurses can report errors and the reasons that led to their occurrence honestly and without fear.