bluuebunny/crossref_metadata_2025_split huggingface dataset:
SALL1 functions as a tumor suppressor in breast cancer by regulating cancer cell senescence and metastasis through the NuRD complex
Authors: Ma Chunling , Wang Fang , Han Bing , Zhong Xiaoli , Si Fusheng , Ye Jian , Hsueh Eddy C. , Robbins Lynn , Kiefer Susan M. , Zhang Yanping , Hunborg Pamela , Varvares Mark A. , Rauchman Michael , Peng Guangyong 
Published: April 2018

Abstract
Background
SALL1 is a multi-zinc finger transcription factor that regulates organogenesis and stem cell development, but the role of SALL1 in tumor biology and tumorigenesis remains largely unknown.

Methods
We analyzed SALL1 expression levels in human and murine breast cancer cells as well as cancer tissues from different types of breast cancer patients. Using both in vitro co-culture system and in vivo breast tumor models, we investigated how SALL1 expression in breast cancer cells affects tumor cell growth and proliferation, metastasis, and cell fate. Using the gain-of function and loss-of-function strategies, we dissected the molecular mechanism responsible for SALL1 tumor suppressor functions.

Results
We demonstrated that SALL1 functions as a tumor suppressor in breast cancer, which is significantly down-regulated in the basal like breast cancer and in estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor 2 (HER2) triple negative breast cancer patients. SALL1 expression in human and murine breast cancer cells inhibited cancer cell growth and proliferation, metastasis, and promoted cell cycle arrest. Knockdown of SALL1 in breast cancer cells promoted cancer cell growth, proliferation, and colony formation. Our studies revealed that tumor suppression was mediated by recruitment of the Nucleosome Remodeling and Deacetylase (NuRD) complex by SALL1, which promoted cancer cell senescence. We further demonstrated that the mechanism of inhibition of breast cancer cell growth and invasion by SALL1-NuRD depends on the p38 MAPK, ERK1/2, and mTOR signaling pathways.

Conclusion
Our studies indicate that the developmental control gene SALL1 plays a critical role in tumor suppression by recruiting the NuRD complex and thereby inducing cell senescence in breast cancer cells.
People with diabetes foot complications do not recall their foot education: a cohort study
Authors: Yuncken Julia , Williams Cylie M. , Stolwyk Rene , Haines Terry P. 
Published: April 2018

AbstractBackgroundThe purpose of this study is to document what and how diabetes specific foot health information was provided during a podiatry consultation, and what information was retained at 1 month post consultation.MethodsThis project was embedded within a prospective cohort study with two groups, podiatrists and people with diabetes. Data collection included the Problem Areas in Diabetes Questionnaire (PAID), Montreal Cognitive Assessment (MoCA), information covered during the consultation, method of delivery and perceived key educational message from both participant perspectives at the time of the appointment and 1 month post appointment.ResultsThere were three podiatrists and 24 people with diabetes who provided information at the two time points. Diabetes education provided by the podiatrists was mostly verbal. The key educational message recalled by both groups differed at the time of the appointment (14 out of 24 of responses) and at 1 month post the appointment time (11 out of 24 of responses).ConclusionsEducation is a vital component to the treatment regime of people with diabetes. It appears current approaches are ineffective in enhancing understanding of diabetes impact on foot health. This study highlights the need for research investigating better ways to deliver key pieces of information to this population.
Neural circuits driving larval locomotion in Drosophila
Authors: Clark Matthew Q. , Zarin Aref Arzan , Carreira-Rosario Arnaldo , Doe Chris Q. 
Published: April 2018

AbstractMore than 30 years of studies into Drosophila melanogaster neurogenesis have revealed fundamental insights into our understanding of axon guidance mechanisms, neural differentiation, and early cell fate decisions. What is less understood is how a group of neurons from disparate anterior-posterior axial positions, lineages and developmental periods of neurogenesis coalesce to form a functional circuit. Using neurogenetic techniques developed in Drosophila it is now possible to study the neural substrates of behavior at single cell resolution. New mapping tools described in this review, allow researchers to chart neural connectivity to better understand how an anatomically simple organism performs complex behaviors.
The prognostic impact of abdominal surgery in cancer patients with neutropenic enterocolitis: a systematic review and meta-analysis, on behalf the Groupe de Recherche en Réanimation Respiratoire du patient d’Onco-Hématologie (GRRR-OH)
Authors: Saillard Colombe , Zafrani Lara , Darmon Michael , Bisbal Magali , Chow-Chine Laurent , Sannini Antoine , Brun Jean-Paul , Ewald Jacques , Turrini Olivier , Faucher Marion , Azoulay Elie , Mokart Djamel 
Published: April 2018

AbstractNeutropenic enterocolitis (NE) is a diagnostic and therapeutic challenge associated with high mortality rates, with controversial opinions on its optimal management. Physicians are usually reluctant to select surgery as the first-choice treatment, concerns being raised regarding the potential risks associated with abdominal surgery during neutropenia. Nevertheless, no published studies comforted this idea, literature is scarce and surgery has never been compared to medical treatment. This review and meta-analysis aimed to determine the prognostic impact of abdominal surgery on outcome of neutropenic cancer patients presenting with NE, versus medical conservative treatment. This meta-analysis included studies analyzing cancer patients presenting with NE, treated with surgical or medical treatment, searched by PubMed and Cochrane databases (1983–2016), according to PRISMA recommendations. The endpoint was hospital mortality. Fixed-effects models were used. The meta-analysis included 20 studies (385 patients). Overall estimated mortality was 42.2% (95% CI = 40.2–44.2). Abdominal surgery was associated with a favorable outcome with an OR of 0.41 (95% CI = 0.23–0.74; p = 0.003). Pre-defined subgroups analysis showed that neither period of admission, underlying malignancy nor neutropenia during the surgical procedure, influenced this result. Surgery was not associated with an excess risk of mortality compared to medical treatment. Defining the optimal indications of surgical treatment is needed.Trial registration PROSPERO CRD42016048952
QER: a new feature selection method for sentiment analysis
Authors: Parlar Tuba , Özel Selma Ayşe , Song Fei 
Published: April 2018

AbstractSentiment analysis is about the classification of sentiments expressed in review documents. In order to improve the classification accuracy, feature selection methods are often used to rank features so that non-informative and noisy features with low ranks can be removed. In this study, we propose a new feature selection method, called query expansion ranking, which is based on query expansion term weighting methods from the field of information retrieval. We compare our proposed method with other widely used feature selection methods, including Chi square, information gain, document frequency difference, and optimal orthogonal centroid, using four classifiers: naïve Bayes multinomial, support vector machines, maximum entropy modelling, and decision trees. We test them on movie and multiple kinds of product reviews for both Turkish and English languages so that we can show their performances for different domains, languages, and classifiers. We observe that our proposed method achieves consistently better performance than other feature selection methods, and query expansion ranking, Chi square, information gain, document frequency difference methods tend to produce better results for both the English and Turkish reviews when tested using naïve Bayes multinomial classifier.
Labour market effects of job displacement for prime-age and older workers
Authors: Deelen Anja , de Graaf-Zijl Marloes , van den Berge Wiljan 
Published: April 2018

AbstractThis paper studies the effects of firm closures associated with bankruptcies on the employment status and wages of prime-age and older workers using Dutch administrative data for the period 2000–2011. Applying difference-in-differences techniques and non-parametric matching, we find adverse effects on the probability to be in work and on wages earned in the new job, which are larger for older workers than for prime-age workers. Within the older-age group, the effects are stronger for formerly long-tenured workers, for older workers who lost their job in declining sectors in the regional labour market and for workers who changed sectors. In the prime-age group, these differences are less pronounced. Our results suggest that job- and sector-specific factors are important for understanding the more vulnerable position of older workers after job loss.
Hemorrhagic stroke after Epley maneuver: A case report
Authors: Moore Paige , Le Trung , Blakley Brian , Beiko Jason , Meen Eric 
Published: April 2018

Background This is the first case to our knowledge of a serious adverse event following the Epley maneuver, which is the treatment of choice for benign paroxysmal positional vertigo (BPPV), the most common vestibular disorder in adults. Case presentation A 77 year old female presented for outpatient evaluation of vertigo at a tertiary otolaryngology clinic. She was found to have BPPV clinically, and elected to have a particle repositioning maneuver (Epley maneuver) performed in clinic. Immediately following Epley maneuver, she had severe nausea and vomiting, with evolving visual changes. A CT angiogram of the brain was performed urgently through the emergency department and demonstrated an acute intraparenchymal hemorrhage in the occipital lobe. After medical stabilization and rehabilitation, the patient continues to have a permanent visual field deficit. Conclusion The Epley maneuver is safe and effective, and there are no prior reports of serious adverse events associated with its use. This case, in which a patient experienced a hemorrhagic stroke after undergoing the Epley maneuver, is the first and sole case in the medical literature of an Epley-associated serious adverse event. The indirect causation and extreme rarity of this event do not warrant any change to patterns of practice.
Compositiones Lucenses and Mappæ Clavicula: two traditions or one? New evidence from empirical analysis and assessment of the literature
Authors: Frison Guido , Brun Giulia 
Published: April 2018

Abstract
Information on materials and procedures of painters of the past can be gained from the latest examinations of a painting and its materials and from documentary sources, the change of meaning of which is of prior interest to historians of technical art. This paper is an empirical and theoretical examination of the relationships between the two main early medieval collections of craft recipes, the Compositiones Lucenses and the Mappæ Clavicula. The primary aim of this work is to criticise the current prevalent meaning of the concept of Mappæ Clavicula, and to show that its tradition does not include that of Compositiones: these two traditions, despite sharing two sets of manuscripts, result in two appreciably different texts. The first edition of the eighth to ninth centuries recipe book Compositiones Lucenses (Lucca, Biblioteca Capitolare, 490) occurred in 1739, and the twelfth century exemplar of Mappæ Clavicula’s text about one century later (Corning, Museum of Glass, Phillipps 3715, or Corning manuscript). In the interwar period and particularly after WWII, the Lucca manuscript was predominantly considered to be a member of the Mappae Clavicula tradition, which was regarded as second only to Theophilus’s De diversis artibus, as a written source for the study of medieval technology. ‘Compositiones Lucenses’ and ‘Mappæ Clavicula’ are taxonomic concepts for the classification of medieval manuscripts and texts, the meanings of which we redefine in this paper. In contrast to today’s prevailing approach, we move the focus from two single manuscripts (Lucca 490 and Corning) to two different traditions of witnesses, and from single texts to collections of texts bound in the same codex. The critical section of the paper concerns the most important interpretations of the notion of Mappæ Clavicula, while the positive section draws on three works: the seminal paper by Halleux and Meyvaert (1980s), Baroni’s first critical edition of Mappæ, and the inventory of the manuscripts of the Compositiones tradition by Brun (2010s). In the empirical section we contrast the two traditions and consider two sets of items: twelve manuscripts reveal the internal structure of the Compositiones Lucenses tradition, and nine codices, which transmit both traditions, shed light on how these traditions differ. As a result of the present research, we show that a significant segment of the Compositiones Lucenses tradition is composed of an aggregation of small recipe nuclei, and that this tradition developed regardless of that of the Mappæ. The Mappæ Clavicula and Compositiones Lucenses are two distinct textual traditions and not members of a super-corpus.
Perceived risks and enjoyment of access-based consumption: identifying barriers and motivations to fashion renting
Authors: Lang Chunmin 
Published: April 2018

AbstractAccess-based consumption, a growing trend in today’s society, provides the consumer with an opportunity to have access to new and diverse products without the burden of ownership. As one form of access-based consumption in the fashion industry, fashion renting still lacks development and popularity. The purpose of this study is to identify how perceived risks and frugal shopping affect the attitudes, perceived enjoyment and further behavioral intention toward the adoption of fashion renting. An online survey was conducted with 452 participants in the United States. Structural equation modeling was employed to test the proposed hypotheses. The results confirmed the negative influences of three perceived risks (financial risk, performance risk, psychological risk) and the positive influences of frugal shopping on attitude toward and perceived enjoyment of fashion renting. Additionally, perceived enjoyment and attitudes were both found having positive influences on consumers’ intention toward fashion renting. This study contributes to existing literature by discovering the effects of perceived risks on attitude and perceived enjoyment of fashion renting and further fashion renting intentions. Managerial suggestions are also provided to promote fashion renting in the future.
Internet-delivered cognitive behavioural therapy for young children with obsessive–compulsive disorder: development and initial evaluation of the BIP OCD Junior programme
Authors: Aspvall Kristina , Andrén Per , Lenhard Fabian , Andersson Erik , Mataix-Cols David , Serlachius Eva 
Published: April 2018

BackgroundInternet-delivered cognitive behavioural therapy (ICBT) is a promising approach for increasing access to evidence-based treatments.AimsTo develop and evaluate the feasibility and preliminary efficacy of an ICBT programme for young children with obsessive–compulsive disorder (OCD), named BIP OCD Junior.MethodEleven children aged 7–11 years were enrolled in a 12-week open trial of parent- and therapist-guided ICBT for OCD. The primary outcome measure was the Children's Yale–Brown Obsessive–Compulsive Scale (CY-BOCS).ResultsThere was a significant improvement in OCD symptoms post-treatment, with a large within-group effect size on the CY-BOCS (Cohen's d = 1.86, 95% CI 0.83 to 2.86). Results were maintained at 3-month follow-up. Both children and parents rated the treatment as credible and were highly satisfied with the intervention.ConclusionsBIP OCD Junior is a feasible and credible treatment option for young children with OCD. Randomised controlled trials are needed to further establish its efficacy and cost-effectiveness relative to gold standard face-to-face CBT.Declaration of interestNone.
Shared decision-making with involuntary hospital patients: a qualitative study of barriers and facilitators
Authors: Giacco Domenico , Mavromara Liza , Gamblen Jennifer , Conneely Maev , Priebe Stefan 
Published: April 2018

BackgroundLast year, there were more than 63 622 involuntary admissions to psychiatric hospitals in England. One of the core principles stipulated in the code of practice for care under the Mental Health Act is involving involuntary patients in care decisions.AimsIdentifying barriers and facilitators to shared decision-making with involuntary patients.MethodFocus groups and individual interviews with patients and clinicians who have experience with involuntary hospital treatment were carried out. Data were subjected to thematic analysis.ResultsTwenty-two patients and 16 clinicians participated. Barriers identified included challenges in communication, and noisy and busy wards making one-to-one meetings difficult. Patient involvement was identified as easier if initiated early after admission and if the whole clinical team was on board. Carers' presence helped decision-making through providing additional information and comfort.ConclusionsThe barriers and facilitators identified can inform changes in the practice of involuntary care to increase patient involvement.Declaration of interestNone.
Od stylizacji do błędu w przekładzie
Authors: Manasterska‑Wiącek Edyta 
Published: April 2018

Modes of expression and misconceptions in translation
The article is devoted to the translation of Mistrz Twardowski by J.I. Kraszewski. The translator rendering the text into another linguistic environment should adjust appropriate modes of expression in order to achieve adequacy. It happens that he gets lost searching for transparency. The analyzed translation abounds with linguistic mistakes that are not a result of the relation between a target language and a translation language. On the stylistic grounds incompatibility and non‑parallelism prevail at all levels. Presumably the frequency of the mistakes will not affect significantly the reader’s perception of the text. The translation is deprived of stylization aimed at the early language and the mistakes do not compensate for the absence of the early language elements that the reader is unaware of.
Increased time between diagnosis and surgery in slipped capital femoral epiphysis results in increased radiographic deformity
Authors: Fedorak G. T. , DeRosa D. C. , Brough A. K. , Miyamoto R. H. 
Published: April 2018

Purpose Previous work has examined the impact of delay of diagnosis in slipped capital femoral epiphysis (SCFE) but not the impact of delay in treatment after radiographic diagnosis. Due to requirements for long distance transportation from less developed regions for many of our patients, our hospital was able to study variation in time between diagnosis and surgery for SCFE, as related to slip severity. Methods This is a retrospective review of patients treated for SCFE between 2005 and 2014 at a tertiary care paediatric hospital. Demographics, time between diagnosis and surgery, radiographic deformity (Southwick angle), postoperative complications and need for further surgery were variables of interest. Statistical analysis included Pearson and Spearman rank correlations and chi-squared tests. Results The study sample included 147 hips (119 patients). Mean time between radiographic diagnosis and surgery was 20.9 days (sd 46, 0 to 321). The mean Southwick angle (SA) at the time of surgery was 31.9° (sd 19.6°, 1° to 83°). There was a significant relationship between increased delay and increased SA (0.34, p < 0.001). Increased SA was correlated with need for future significant surgery (0.27, p < 0.01). Patients from less-developed regions, with barriers to timely care, had moderate and severe deformity (SA) (p < 0.01), and required significant further surgery more often than SCFE patients from the local population (p < 0.01) Conclusion The unique referral environment of our hospital provided an opportunity to examine traditional recommendations for treating SCFE promptly after radiographic diagnosis. Delay in treatment is correlated with increased radiographic deformity. Level of Evidence III
Tuning the Photophysical Properties of Cyanine Dyes with Clay Minerals
Authors: Boháč Peter , Bujdák Juraj 
Published: April 2018

AbstractDye molecular aggregation and other interactions on clay mineral surfaces cause phenomena such as methachromasy (change in color), fluorescence enhancement, or quenching, which represent significant changes in the spectral properties of the dye. These phenomena can be used to control the photophysical properties of hybrid systems based on cationic organic dyes. In the present study, the aggregation of two structurally similar cyanine dyes, 3,3’-diethyl-oxocyanine iodide (OxCy) and 3,3’-diethyl-2,2’-thiacyanine iodide (ThCy), in colloidal dispersions of three smectites (saponite, hectorite, and montmorillonite) was studied by absorption and fluorescence spectroscopy for a broad range of dye/smectite loadings. Spectral data were analysed by chemometric methods (principal component analysis, PCA, and multivariate curve resolution, MCR). Detailed analysis of the OxCy absorption spectra by the chemometric methods revealed the formation of two types of oblique aggregates exhibiting light absorption in both H- and J-bands. The existence of such similar aggregates, with similar splitting of excitation energies, appears to be related to the existence of two stable conformational isomers of this dye. On increasing the smectite CEC and dye/smectite loading, fluorescence quenching occurred. The ThCy dye exhibited a stronger tendency for molecular aggregation than OxCy. On increasing the smectite CEC, the formation of oblique aggregates with dominant H-bands also increased. On aging of the hybrid dispersions, equilibria of ThCy aggregates were shifted to the species with dominant J-bands. This behavior had a significant impact on the shape and intensity of the fluorescence emission of the hybrid dispersions. Using different smectites enables control of the dye aggregation and significant change to the photophysical properties of the hybrid systems. These systems can be used for the detailed study of the photophysical properties of cyanine dyes in various states. The colloidal systems with cyanine dyes can be used as precursors for the preparation of novel hybrid materials. In addition, the sensitive response of the photophysical properties of cyanine dyes to the clay mineral surface can be applied to the characterization of clay minerals.