bluuebunny/crossref_metadata_2025_split huggingface dataset:
Busy Businesses and Busy Contexts: The Distribution and Sources of Crime at Commercial Properties
Authors: Tillyer Marie Skubak , Walter Rebecca J. 
Published: May 2019

Objective: Examine the distribution and sources of crime across freestanding businesses in San Antonio. We test hypotheses about the main and interactive effects of neighborhood and business characteristics on crime at the business, with a focus on busy contexts and busy businesses. Method: Police crime incident data are spatially joined to study area business parcels. Additional data sources include Infogroup USA Business Data, the American Community Survey, and an Environmental Protection Agency traffic activity indicator. Multilevel negative binomial regression models are estimated to observe the main and interactive effects of census block group and business variables on crime at the parcel. Results: Businesses located in block groups with more commercial property and high levels of vehicular traffic experience more crime. In addition, crime is higher at “busy” businesses, as indicated by employee size, sales volume, and square footage. Busy contexts and busy businesses do not appear to interact to increase crime at the parcel beyond their main effects. Conclusions: Crime is clustered at relatively few businesses, and this variation cannot be explained by business type alone. Both neighborhood and business characteristics are associated with crime at freestanding businesses, with busy businesses and those within busier block groups experiencing more crime.
Role of the galanin N-terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system
Authors: Millón Carmelo , Flores-Burgess Antonio , Gago Belén , Alén Francisco , Orio Laura , García-Durán Laura , Narváez José A , Fuxe Kjell , Santín Luis , Díaz-Cabiale Zaida 
Published: May 2019

Background: Anhedonia is a core feature of depressive disorders. The galanin N-terminal fragment (1-15) plays a role in mood regulation since it induces depression and anxiogenic-like effects in rats. In this study, we analysed galanin N-terminal fragment (1-15) actions in anhedonic-like behaviours in rats using operant and non-operant tests and the areas involved with these effects. Methods: Galanin N-terminal fragment (1-15) effects were analysed in saccharin self-administration, sucrose preference, novelty-suppressed feeding and female urine sniffing tests. The areas involved in galanin N-terminal fragment (1-15)-mediated effects were studied with positron emission tomography for in vivo imaging, and we analysed the ventral tegmental area and nucleus accumbens. Galanin N-terminal fragment (1-15) had effects on the mRNA expression of the dopamine transporters Dat and Vmat2; the C-Fos gene; the dopamine receptors D1, D2, D3, D5; and the galanin receptors 1 and 2. Results: Galanin N-terminal fragment (1-15) at a concentration of 3 nmol induced a strong anhedonia-like phenotype in all tests. The involvement of galanin receptor 2 was demonstrated with the galanin receptor 2 antagonist M871 (3 nmol). The 18F-fluorodeoxyglucose positron emission tomography images indicated the action of galanin N-terminal fragment (1-15) over several nuclei of the limbic system. Galanin N-terminal fragment (1-15)-mediated effects also involved changes in the expression of Dat, Vmat2, D3 and galanin receptors in the ventral tegmental area as well as the expression of C-Fos, D1, D2 and D3 and TH immunoreactivity in the nucleus accumbens. Conclusions: Our results indicated that galanin N-terminal fragment (1-15) exerts strong anhedonic-like effects and that this effect was accompanied by changes in the dopaminergic mesolimbic system. These results may provide a basis for the development of novel therapeutic strategies using galanin N-terminal fragment (1-15) analogues for the treatment of depression and reward-related diseases.
Lamotrigine augmentation in treatment-resistant unipolar depression: A comprehensive meta-analysis of efficacy and safety
Authors: Goh Kah Kheng , Chen Chun-Hsin , Chiu Yi-Hang , Lu Mong-Liang 
Published: May 2019

Objective: Augmentation strategies are commonly applied when an individual is unresponsive to antidepressant monotherapy. Lamotrigine is currently considered at best only as second line augmentation for treatment-resistant unipolar depression while its clinical efficacy and safety profiles remain inconclusive. We intended to assess the therapeutic effects and safety profiles of lamotrigine augmentation in patients with treatment-resistant unipolar depression by conducting a meta-analysis. Methods: MEDLINE, Embase, EBSCO, Cochrane, Web of Science, Scopus, Wanfang and Ariniti databases were searched. Coprimary outcomes, including changes in severity of depression and response rate, were measured in this study. Secondary outcomes were defined as the safety profile of the intervention, including reported discontinuation rate and adverse events. Results: Eight double-blinded randomized controlled trials with 677 patients overall were included. Significant improvements in Hamilton Rating Scale for Depression scores and response rates were shown in lamotrigine augmentation groups compared with control groups, of which the pooled result of six Chinese studies showed positive effects of Hamilton Rating Scale for Depression improvement while the pooled result of two non-Chinese studies was statistically non-significant. Patients with more severe illness and longer duration of illness were more effectively treated with lamotrigine augmentation. The magnitude of depression improvement after lamotrigine augmentation was higher in patients treated with selective serotonin reuptake inhibitors than those treated with serotonin-norepinephrine reuptake inhibitors. Lamotrigine augmentation is well-tolerated in terms of all-cause discontinuation rate and adverse events. Conclusions: Lamotrigine augmentation may serve as a possible choice for patients with treatment-resistant unipolar depression and further trials are warranted to clarify the optimal dosage of lamotrigine augmentation together with the treatment duration and safety over time.
Patterns of initially overlooked recurrence of peritoneal lesions in patients with advanced ovarian cancer on postoperative multi-detector row CT
Authors: Bae Heejin , Jung Dae Chul , Lee Jung-Yun , Nam Eun Ji , Kang Won Jun , Oh Young Taik 
Published: May 2019

Background In order to obtain timely treatment, the early detection of recurrent ovarian cancer is essential. Despite technical advances in multi-detector row computed tomography (MDCT), low sensitivity of CT for recurrence has not been improved much due to its poor soft tissue discrimination. Purpose The aim of this study is to describe patterns of erroneous postoperative MDCT interpretation of recurred peritoneal lesions in patients with advanced ovarian cancer (AOC). Material and methods Between 2011 and 2018, we reviewed postoperative follow-up positron emission tomography (PET)/CT images of 240 patients with suspected recurrence based on the images and history of initially diagnosed AOC (International Federation of Gynecology and Obstetrics stage IIIC–IV) who had undergone primary cytoreduction. With awareness of recurred location, we re-evaluated MDCT images taken right before the recurrence was detected on PET/CT and categorized these cases as either the absence of a lesion or the presence of a lesion (missed case). We performed region-based comparisons of these missed cases according to predefined peritoneal locations. Results Re-evaluation of follow-up MDCT images revealed that 46.9% (105/224) of recurrent lesions were missed. Through region-based analysis, the most commonly missed site was the pelvic cavity (19.0%, 20/105), followed by the porta hepatis (15.2%, 16/105) and the para-aortic/aortocaval lymphadenopathy (13.3%, 14/105). Conclusion Radiologists should be concerned about these frequently overlooked regions in postoperative follow-up MDCT images when potential risks are identiﬁed. Familiarity with these imaging features may aid in the detection of recurrence and facilitate appropriate management.
Minimally invasive resection of a glomus tumor of the thoracic spine: a case report and literature review
Authors: Liao Zhiwei , Chen Chao , Wang Bingjin , Yang Cao 
Published: May 2019

Objective Spinal involvement of glomus tumors is extremely rare. We herein present a case of a spinal glomus tumor and reviewed the literature to identify the most effective surgical treatment of spinal glomus tumors. Methods A 48-year-old man presented with a huge paravertebral space-occupying lesion. In this report, we present the diagnostic process and surgical procedure in this case and review the literature of glomus tumors with spine involvement. Results We suspected a primary diagnosis of neurilemmoma based on the imaging results; however, the postoperative pathologic examination confirmed a glomus tumor. Considering the size of the tumor and involvement of surrounding areas, we performed complete tumor resection and unilateral fusion with pedicle screws at the T2 to T4 level. This unilateral approach with fixation was less invasive than the standard open posterior approaches that are used when one side of the spinal canal is intact without bony destruction. Conclusions Surgical resection is a suitable treatment for most symptomatic glomus tumors. For most glomus tumors with spine involvement, total tumor resection with suitable internal fixation and fusion is recommended.
Biocompatibility and cellular compatibility of decellularized tracheal matrix derived from rabbits
Authors: Zhang Fangbiao , Wang Zhihao , Zheng Chunhui , Zhao Chun , Shi Hongcan , Pan Shu , Zhang Weidong 
Published: May 2019

Objective: To study the different concentrations of Triton X-100 and nuclease needed to remove cells from the tracheal matrix of rabbits and analyse their biocompatibility and cellular compatibility. Methods: Fifty tracheas were harvested from donor New Zealand rabbits. Thirty tracheas were randomly divided into five groups (n = 6 each). The tracheas in group A were untreated and served as a control group, and those in groups B, C, D and E were treated with different concentrations of Triton X-100 (1%, 2%, 3% and 4%), respectively. The tracheas of the five groups were assessed by histological observation, scanning electron microscopy and mechanical evaluation. The remaining 20 donor tracheas, which were divided into a control group and an optimally decellularized group, were used for xenogeneic transplantation and cell seeding. Results: Many epithelial cells and cartilage cells were observed in the tracheas of group A. There were fewer cartilage cells in the tracheas of groups C, D and E than in the tracheas of groups A and B under histological observation. In scanning electron microscopy, there were many ciliated epithelial cells in the tracheas of group A; in groups B and C, the ciliated epithelial cells disappeared, but the basement membrane was intact. The basement membranes were broken in the tracheas of groups D and E. Implanted decellularized tracheas showed good biocompatibility. Bone marrow mesenchymal stem cells grown in the decellularized tracheal matrix grew well. Conclusion: Decellularized tracheal matrix obtained from rabbits by 2% Triton X-100 may be suitable for the construction of tissue-engineered trachea because of its favourable morphological and biomechanical properties as well as its biocompatibility and cellular compatibly.
What Does Political Economy Tell Us About the Dearth of Black Entrepreneurs?
Authors: Mangum Vincent E. 
Published: May 2019

There is a historical and consistent lack of parity in the Black community between labor and firms. Various authors have attributed entrepreneur-centered failures and shortcomings as the source of Black Entrepreneurship under-performance. This study, however, utilizing the Theory of Market Barriers, sought to discover the factors associated with market conditions that may play a causal role on new firm entry and coincidentally entrepreneurship choice. With count data from the Survey of Minority Owned Enterprises 1992-1997 (SMOBE), this study estimated the parameters of a Limit Profit Model to determine the effect political economic barriers have on new firm entry. The results implicate historical and ongoing biased policy generating imperfect market conditions lowering the economic value of entrepreneurial choice and hindering Black Entrepreneurship. This suggests that among the various explanations for the dearth of Black entrepreneurs, low Black labor demand and persistent high Black unemployment, barriers emanating from political economy, also appear to be important. JEL Classifications: I, J, O
Associations Between Stress and Cardiovascular Disease Risk Factors Among Million Hearts Priority Populations
Authors: Gawlik Kate Sustersic , Melnyk Bernadette Mazurek , Tan Alai 
Published: May 2019

Purpose: To estimate the effects of stress on hypertension and high cholesterol with a focus on Million Hearts priority populations. Design: A population-based cross-sectional survey on cardiovascular health and its risk factors. Setting: Million Hearts cardiovascular community screenings Sample: Deidentified data were collected on a convenience sample of 59 798 participants. Measures: Self-reported stress score using the Perceived Stress Scale-4 (PSS-4), blood pressure, and total cholesterol. Analysis: Descriptive statistics were used to estimate the prevalence of high stress (PSS-4 score ≥ 9), prehypertension or hypertension, and elevated total cholesterol. Multiple logistic regression modeling was used to estimate the effect of stress on the risk of elevated blood pressure and total cholesterol. Results: Twenty-four percent of the participants had high stress. Younger participants had an increased prevalence of high stress than older participants (28% vs 20%, P < .001). African Americans had a high prevalence of stress (26.4%), prehypertension or hypertension (65.4%), and elevated total cholesterol (48.6%). Compared to those with low stress, high stress was associated with significant higher risks of having prehypertension/hypertension (odds ratio [OR] = 1.40, 95% confidence interval [CI] = 1.28-1.53) and elevated cholesterol (OR = 1.53, 95% CI = 1.41-1.66). Conclusions: Stress needs to be routinely identified and treated, especially in Million Hearts priority populations. More research is needed in designing culturally sensitive and effectively tailored interventions relative to both stress and disease management.
Ultrasound-guided anatomical evaluation and percutaneous cannulation of the right internal jugular vein in infants <4000 g
Authors: Uzumcugil Filiz , Yilbas Aysun Ankay , Akca Basak 
Published: May 2019

Background: The commonly preferred right internal jugular vein was investigated in terms of its dimensions, the relationship between its dimensions and anthropometric measures, and the outcomes of its cannulation in infants. Data regarding its position with respect to the carotid artery indicated anatomical variation. Aim: The aim of this study was to share our observations pertaining to the anatomy and position of the right internal jugular vein with respect to carotid artery using ultrasound and our experience with ultrasound-guided right internal jugular vein access in neonates and small infants. Materials and methods: A total of 25 neonates and small infants (<4000 g) undergoing ultrasound-guided central venous cannulation via right internal jugular vein within a 6-month period were included. Ultrasound-guided anatomical evaluation of the vein was used to obtain the transverse and anteroposterior diameters, the depth from skin and the position with respect to the carotid artery. Real-time ultrasound-guided central cannulation success rates and complication rates were also obtained. The patients were divided into two groups with respect to their weight in order to compare both the position and the dimensions of right internal jugular vein and cannulation performance in infants weighing <2500 g and ⩾2500 g. Results: The position was lateral to the carotid artery in 84% of all infants and similar in both groups. The first-attempt success rates of cannulation were similar (70% vs 73.3%) in both groups, with an overall success rate of 88%. Conclusion: Right internal jugular vein revealed a varying position with respect to carotid artery with a higher rate of lateral position. The presence of such anatomical variation requires ultrasonographic evaluation prior to interventions and real-time guidance during interventions involving right internal jugular vein.
Functional brain connectivity abnormalities and cognitive deficits in neuromyelitis optica spectrum disorder
Authors: Savoldi Filippo , Rocca Maria A , Valsasina Paola , Riccitelli Gianna C , Mesaros Sarlota , Drulovic Jelena , Radaelli Marta , Filippi Massimo 
Published: May 2019

Background: Functional magnetic resonance imaging (fMRI) correlates of cognitive deficits have not been thoroughly studied in patients with neuromyelitis optica spectrum disorders (NMOSDs). Objective: To investigate resting state (RS) functional connectivity (FC) abnormalities within the main cognitive networks in NMOSD patients and their correlation with cognitive performance. Methods: We acquired RS fMRI from 25 NMOSD patients and 30 healthy controls (HC). Patients underwent an extensive neuropsychological evaluation. Between-group RS FC comparisons and correlations with cognitive performance were assessed on the main cognitive RS networks identified by independent component analysis. Results: NMOSD patients showed higher RS FC versus HC in the precuneus of the default mode network (DMN) and right working memory network (WMN), as well as in several frontoparietal regions of the salience network (SN) and bilateral WMNs. Reduced frontal RS FC in NMOSD versus HC was detected in the left WMN. Increased RS FC in the DMN and right WMN was correlated with better cognitive performance, while decreased RS FC in the left WMN was associated with worse cognitive performance. Conclusion: Cognitive-network reorganization occurs in NMOSD. Clinico-imaging correlations suggest an adaptive role of increased RS FC. Conversely, reduced RS FC seems to be a maladaptive mechanism associated with a worse cognitive performance.
Deep grey matter involvement and altered sensory gating in multiple sclerosis
Authors: Conte Antonella , Giannì Costanza , Belvisi Daniele , Cortese Antonio , Petsas Nikolaos , Tartaglia Matteo , Cimino Paola , Millefiorini Enrico , Berardelli Alfredo , Pantano Patrizia 
Published: May 2019

Background: Somatosensory temporal discrimination threshold (STDT) is altered in multiple sclerosis (MS). In healthy subjects (HS), voluntary movement modulates the STDT through mechanisms of subcortical sensory gating. Objective: With neurophysiological and magnetic resonance imaging (MRI) techniques, we investigated sensory gating and sensorimotor integration in MS. Methods: We recruited 38 relapsing-remitting multiple sclerosis (RR-MS) patients with no-to-mild disability and 33 HS. We tested STDT at rest and during index finger abductions and recorded the movement kinematics. Participants underwent a 3T MRI protocol. Results: Patients exhibited higher STDT values and performed slower finger movements than HS. During voluntary movement, STDT values increased in both groups, albeit to a lesser extent in patients, while the mean angular velocity of finger movements decreased in patients alone. Patients had a smaller volume of the thalamus, pallidum and caudate nucleus, and displayed higher mean diffusivity in the putamen, pallidum and thalamus. STDT correlated with thalamic volume while mean angular velocity correlated with putaminal volume. Changes in mean angular velocity during sensorimotor integration inversely correlated with mean diffusivity in the thalamus and pallidum. Changes in STDT and velocity were associated with fatigue score. Conclusion: Altered STDT and sensorimotor integration are related to structural damage in the thalamus and basal ganglia in MS and likely to affect motor performance.
Vitamin D genes influence MS relapses in children
Authors: Graves Jennifer S , Barcellos Lisa F , Krupp Lauren , Belman Anita , Shao Xiaorong , Quach Hong , Hart Janace , Chitnis Tanuja , Weinstock-Guttman Bianca , Aaen Gregory , Benson Leslie , Gorman Mark , Greenberg Benjamin , Lotze Timothy , Soe Mar , Ness Jayne , Rodriguez Moses , Rose John , Schreiner Teri , Tillema Jan-Mendelt , Waldman Amy , Casper T Charles , Waubant Emmanuelle 
Published: May 2019

Objective: The aim of this study was to determine whether a vitamin D genetic risk score (vitDGRS) is associated with 25-hydroxyvitamin D (25(OH)D) level and multiple sclerosis (MS) relapses in children. Methods: DNA samples were typed for single nucleotide polymorphisms (SNPs) from four genes previously identified to be associated with 25(OH)D levels. SNPs with strong associations with 25(OH)D after multiple comparison correction were used to create a genetic risk score (vitDGRS). Cox regression models tested associations of vitDGRS with relapse hazard. Results: Two independent SNPs within or near GC and NADSYN1/DHCR7 genes were strongly associated with 25(OH)D levels in the discovery cohort ( n = 182) after Bonferroni correction. The vitDGRS of these SNPs explained 4.5% of the variance of 25(OH)D level after adjustment for genetic ancestry. Having the highest versus lowest vitDGRS was associated with 11 ng/mL lower 25(OH)D level (95% confidence interval (CI) = −17.5, −4.5, p = 0.001) in the discovery cohort. Adjusting for ancestry, sex, disease-modifying therapy (DMT), and HLA-DRB1*15 carrier status, the highest versus lowest vitDGRS was associated with 2.6-fold (95% CI = 1.37, 5.03, p = 0.004) and 2.0-fold (95% CI = 0.75, 5.20, p = 0.16) higher relapse hazard in the discovery and replication cohorts, respectively. Conclusion: The vitDGRS identifies children at greater risk of relapse. These findings support a causal role for vitamin D in MS course.
Longitudinal changes in left ventricular structure and function in patients with type 2 diabetes: Normal weight versus overweight/obesity
Authors: Kim Seong Hwan , Sung Ki-Chul , Lee Seung Ku , Park Juri , Kim Nan Hee , Kim Sun H , Shin Chol 
Published: May 2019

Objective: Although reported to be independent of obesity, the longitudinal changes of left ventricular structure and function have not been well characterized in normal-weight individuals with type 2 diabetes compared with overweight/obese individuals with type 2 diabetes. Methods: A total of 558 participants in the Korean Genome and Epidemiology Study who underwent tissue Doppler echocardiography at baseline (cycle 4) and after 8 years (cycle 8) were classified into three groups based on body mass index and diabetes status: (1) normal-weight individuals without type 2 diabetes, (2) normal-weight individuals with type 2 diabetes and (3) overweight/obese individuals with type 2 diabetes. Results: Only overweight/obese individuals with type 2 diabetes group had higher adjusted left ventricular mass index and lower tissue Doppler imaging early diastolic velocity and E/Em ratio compared with the normal-weight individuals without type 2 diabetes group at baseline and after 8 years. Participants in overweight/obese individuals with type 2 diabetes group also showed the higher prevalence and odds of left ventricular hypertrophy (16.0%; adjusted odds ratio: 2.24; 95% confidence interval: 1.22–5.06) and left ventricular diastolic dysfunction (49.1%; 3.45; 1.01–4.32). Among participants with normal left ventricular structure and function at baseline, only overweight/obese individuals with type 2 diabetes group was associated with greater incidence of left ventricular hypertrophy (relative risk: 2.28; 1.04–4.98) over 8 years but not diastolic dysfunction. Conclusion: Cross-sectional and longitudinal observations suggest that increasing body mass index category and its associated metabolic abnormalities at baseline are associated with an increased risk for left ventricular hypertrophy and greater impairment in left ventricular diastolic parameters.