bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative autologous blood donation in adult bone marrow donors: reappraisal of a single‐centre experience
Authors: Teofili Luciana , Valentini Caterina Giovanna , Bianchi Maria , Pellegrino Claudio , Bellesi Silvia , Chiusolo Patrizia , Laurenti Luca , Innocenti Idanna , De Stefano Valerio , Bacigalupo Andrea 
Published: August 2019

AbstractTo avoid risk for allogeneic transfusions in healthy bone marrow (BM) donors, 1–2 preoperative autologous blood donations (PAD) are usually collected before the BM harvest. We analysed the haematological parameters in BM donors before and after the harvest, to assess the efficacy of this practice in limiting the postharvest anaemia. Overall, 102 consecutive donors underwent BM harvest preceded by one (26 cases) or two PAD (76 cases), which were infused during BM collection. We analysed the parameters related to donors, PAD timing and BM graft characteristics. PAD induced a significant decrease in Hb (from 14·6 g/dl, IQ range 13·3–15·5 to12·9 g/dl, IQ range 11·8–13·9; P < 0·0001) in all donors, with a median Hb loss at day −1 of 10·9% (IQ range 6·8–14·2). The PAD‐related Hb decrease was independent of sex or number of PAD, and was inversely related to the time elapsed from first or last PAD. In comparison with values recorded at day‐1, BM harvest produced an additional Hb decrease, accounting for a median Hb loss of 18·9% (IQ range 14·9–24·4). Overall, in comparison with pre‐PAD values, Hb levels at day +1 were reduced of 28·9% (IQ range 23·6–32·2), independently if donors had 1 or 2 PAD reinfused. In conclusion, these data show that two PAD do not carry any advantage over one PAD. An eventual benefit of PAD can be achieved only if an adequate interval between PAD and BM harvest elapses. Prospective randomized studies could be worth to establish if any role for PAD does exist in BM donors.
Willingness‐to‐pay for water resource protection in El Salvador
Authors: Keough Adam , Vásquez William F. 
Published: August 2019

AbstractEstimates of the economic value that the society assigns to improved water resources may help prioritize public investments in watershed protection. Using a contingent valuation survey, this study elicited household willingness to pay for watershed protection in two poor, semi‐urban communities in El Salvador. Findings indicate that local households have strong preferences for protecting their watershed. The average willingness to pay is estimated at three US dollars per month, equivalent to 1.5% of the average monthly household income. Results also suggest that there is a significant willingness to pay differential between studied communities, and that more educated respondents are willing to pay more for watershed protection than less educated individuals. These estimates have the potential to influence investment decisions regarding watershed conservation in semi‐urban areas.
Mobility of copper and its micro‐structure characteristics in contaminated river sediment through stabilization by using cement and rice husk ash
Authors: Aliyu Mohammed Kabir , Karim Ahmad Tarmizi Abd , Chan Chee‐Ming , Oyekanmi Adeleke Abdulrahman , Hossain Kaizar , Ismail Norli 
Published: August 2019

AbstractThe effectiveness of replacing cement with rice husk ash (RHA) on the leachability of copper from stabilized sediment was studied. RHA was added at 5, 10 15 and 20% and also cement was added at 10% throughout to the total dry weight of mixture, after which curing was undertaken at room atmosphere for 7, 14 and 28 days. The immobilization efficiency of amendments was evaluated using TCLP and SPLP. The high percentage efficiency of treatment was observed for the TCLP as 97.82 and 99.92% at 28 days for the SPLP. Characterization study was carried out using X‐ray diffraction (XRD) analysis to study the reaction products and crystalline phases of the treated sediment after 28 days to observe the possible mechanisms responsible for the immobilization of the investigated heavy metal. Results have indicated that partial replacement of cement with RHA in binder system has increased the strength and reduced leachability of copper of the treated sediment compared to untreated sediment.
The impact of parent-targeted eHealth educational interventions on infant procedural pain management: a systematic review protocol
Authors: Richardson Brianna , Benoit Britney , Rutledge Kallen , Dol Justine , Misener Ruth Martin , Latimer Margot , Smit Michael , McGrath Patrick , Campbell-Yeo Marsha 
Published: August 2019

ABSTRACT

Objective:
The objective of this review is to determine if electronic health (eHealth) educational interventions for infant procedural pain and pain management impact parental outcomes (mental health outcomes, knowledge utilization outcomes, and parental involvement in care outcomes) and infant outcomes (morbidity outcomes, pain outcomes, health system outcomes).

Introduction:
Pain in infants is a common concern for parents. Routine postpartum care for infants in early life requires them to endure painful procedures, yet infants often receive little to no pain management. While research has shown that parents can reduce their infant's pain during procedures by breastfeeding or skin-to-skin contact, parents may not be aware of their role in pain management. Despite the recent rapid increase in eHealth resources to educate parents about infant pain management, their impact has yet to be evaluated.

Inclusion criteria:
This review will consider studies that include eHealth educational interventions targeted at parents during pregnancy and up to one year postpartum. All experimental study designs will be included. Primary outcomes will include: parental stress and anxiety, self-efficacy, knowledge, attitudes, eHealth intervention usage, acceptance of eHealth intervention, involvement in pain management, and infant pain response.

Methods:
PubMed, CINAHL, PsycINFO, Embase, Scopus, Web of Science, and SciELO will be searched for studies published in English. Critical appraisal and data extraction will be conducted by two independent reviewers using standardized tools. Quantitative data, where possible, will be pooled in statistical meta-analysis, or if statistical pooling is not possible, the findings will be reported narratively.
Tubey or not tubey: Death beds of Ediacaran macrofossils or microbially induced sedimentary structures?
Authors: Nelson Lyle L. , Smith Emily F. 
Published: August 2019

Abstract
Within the upper Ediacaran Esmeralda Member of the Deep Spring Formation in southeastern California, USA, an ∼3 m stratigraphic interval contains multiple clastic bedding surfaces with enigmatic, three-dimensionally preserved corrugated tubes (<60 cm in length and 6 cm in width). When viewed as fragments and in situ on bedding planes, these resemble larger versions of annulated, tubular soft-bodied macrofossils that are common in late Ediacaran biotic assemblages regionally and globally. Despite superficial similarities to casts and molds of body fossils preserved in correlative strata, we suggest these tubes are instead previously undescribed organosedimentary structures that developed through differential compaction of rippled heterolithic interbeds bound by pyritized microbial mat layers. These distinctive structures formed within peritidal settings in the latest Ediacaran Period as the result of specific ecological and environmental conditions marked by flourishing microbial mat communities and dysoxic sediments. This interpretation may inform the biogenicity of other structures previously reported as macroscopic body or trace fossils.
Modeling petroleum expulsion in sedimentary basins: The importance of igneous intrusion timing and basement composition
Authors: Gardiner David , Schofield Nick , Finlay Alex , Mark Niall , Holt Liam , Grove Clayton , Forster Chris , Moore Julian 
Published: August 2019

Abstract
The concept of a critical moment in a petroleum system (the time of highest probability of entrapment and preservation of oil and gas) has underlain petroleum exploration for over 25 years. However, one area where understanding the critical moment is challenging is the Faroe-Shetland Basin (FSB; offshore UK). Isotopic dating of oils suggests that petroleum generation began between ca. 68 and 90 Ma; however, most basin models invoke an earlier generation beginning in the mid-Cretaceous at ca. 100 Ma, predating deposition of Paleocene and Eocene reservoirs. This time discrepancy has previously been explained by remigration from intermediary accumulations (“motel” hypothesis) and/or overpressure retardation of kerogen maturation. The FSB is characterized by a thick Cretaceous stratigraphic package (up to 5 km) that includes a large net thickness (up to 2 km) of Paleogene igneous material. In our model, separating sedimentary and igneous material and adding the igneous material at the correct time between ca. 58 and 55 Ma shallows the modeled burial depth of the Upper Jurassic source rocks during the Cretaceous sufficiently to delay maturation by 17 m.y. in comparison to results of previous studies. Additionally, previous studies have invoked crustal radiogenic heat production (RHP) based on the Phanerozoic crust averaging ∼2.8 µW/m3 in the North Sea (300 km to the east). However, the FSB basement is composed of significantly older, colder Neoarchean orthogneisses (ca. 2.7–2.9 Ga), reducing RHP by up to 50% to ∼1.6 µW/m3 (σ = 0.74). For the first time, our model unifies geological, geochronological, and geochemical observations, delaying the onset of petroleum expulsion by up to 40 m.y. in comparison to previous models.
Hospital revisits within 30 days after discharge for medical conditions targeted by the Hospital Readmissions Reduction Program in the United States: national retrospective analysis
Authors: Wadhera Rishi K , Joynt Maddox Karen E , Kazi Dhruv S , Shen Changyu , Yeh Robert W 
Published: August 2019

AbstractObjectiveTo determine any changes in total hospital revisits within 30 days of discharge after a hospital stay for medical conditions targeted by the Hospital Readmissions Reduction Program (HRRP).DesignRetrospective cohort study.SettingHospital stays among Medicare patients for heart failure, acute myocardial infarction, or pneumonia between 1 January 2012 and 1 October 2015.ParticipantsMedicare fee-for-service patients aged 65 or over.Main outcomesTotal hospital revisits within 30 days of discharge after hospital stays for medical conditions targeted by the HRRP, and by type of revisit: treat-and-discharge visit to an emergency department, observation stay (not leading to inpatient readmission), and inpatient readmission. Patient subgroups (age, sex, race) were also evaluated for each type of revisit.ResultsOur study cohort included 3 038 740 total index hospital stays from January 2012 to September 2015: 1 357 620 for heart failure, 634 795 for acute myocardial infarction, and 1 046 325 for pneumonia. Counting all revisits after discharge, the total number of hospital revisits per 100 patient discharges for target conditions increased across the study period (monthly increase 0.023 visits per 100 patient discharges (95% confidence interval 0.010 to 0.035)). This change was due to monthly increases in treat-and-discharge visits to an emergency department (0.023 (0.015 to 0.032) and observation stays (0.022 (0.020 to 0.025)), which were only partly offset by declines in readmissions (−0.023 (−0.035 to −0.012)). Increases in observation stay use were more pronounced among non-white patients than white patients. No significant change was seen in mortality within 30 days of discharge for target conditions (−0.0034 (−0.012 to 0.0054)).ConclusionsIn the United States, total hospital revisits within 30 days of discharge for conditions targeted by the HRRP increased across the study period. This increase was due to a rise in post-discharge emergency department visits and observation stays, which exceeded the decline in readmissions. Although reductions in readmissions have been attributed to improvements in discharge planning and care transitions, our findings suggest that these declines could instead be because hospitals and clinicians have intensified efforts to treat patients who return to a hospital within 30 days of discharge in emergency departments and as observation stays.
Team-based outpatient early palliative care: a complex cancer intervention
Authors: Zimmermann Camilla , Ryan Suzanne , Hannon Breffni , Saltman Alexandra , Rodin Gary , Mak Ernie , Al-Awamer Ahmed , Lau Jenny 
Published: August 2019

BackgroundAlthough the effectiveness of early palliative care for patients with advanced cancer has been demonstrated in several trials, there has been no detailed published description of an early palliative care intervention.MethodIn this paper, we delineate the iterative conception and systematic evaluation of a complex intervention called team-based outpatient early palliative care (TO-EPC), and describe the components of the intervention. The intervention was developed based on palliative care theory, review of previous palliative care interventions and practice guidelines. We conducted feasibility testing and piloting of TO-EPC in a phase 2 trial, followed by evaluation in a large cluster randomised trial and qualitative research with patients and caregivers. The qualitative research informed the iterative refinement of the intervention.ResultsFour principles and four domains of care constitute a conceptual framework for TO-EPC. The main domains of care are: coping and support, symptom control, decision-making and future planning. The main principles are that care is flexible, attentive, patient-led and family-centred. The most prominent domain for the initial consultation is coping and support; follow-up visits focus on symptom control, decision-making to maximise quality of life and future planning according to patient readiness. Key tasks are described in relation to each domain.ConclusionThe description of our intervention may assist palliative care teams seeking to implement it, researchers wishing to replicate or build on it and oncologists hoping to adapt it for their patients.
Cluster randomised control trial for cricket injury prevention programme (CIPP): a protocol paper
Authors: Soomro Najeebullah , Chua Nina , Freeston Jonathan , Ferdinands Rene E D , Sanders Ross 
Published: August 2019

BackgroundInjury prevention programmes (IPPs) are effective in reducing injuries among adolescent team sports. However, there is no validated cricket-specific IPP despite the high incidence of musculoskeletal injuries among amateur cricketers.ObjectivesTo evaluate whether a cricket injury prevention programme (CIPP) as a pretraining warm-up or post-training cool-down can reduce injury rates in amateur cricket players.MethodsCIPP is a cluster randomised controlled trial which includes 36 male amateur club teams having cricket players aged 14–40 years to be randomly assigned to three study arms: warm-up, cool-down and control (n=12 teams, 136 players in each arm). The intervention groups will perform 15 min CIPP either as a pretraining warm-up or a post-training cool-down.Outcome measuresThe primary outcome measure will be injury incidence per 1000 player hours and the secondary outcome measures will be whether IPP as a warm-up is better than IPP as a cool-down, and the adherence to the intervention.Trial registration numberACTRN 1261700047039.
Rotating night shift work and risk of multiple sclerosis in the Nurses’ Health Studies
Authors: Papantoniou Kyriaki , Massa Jennifer , Devore Elizabeth , Munger Kassandra L , Chitnis Tanuja , Ascherio Alberto , Schernhammer Eva S 
Published: August 2019

ObjectivesNight shift work has been suggested as a possible risk factor for multiple sclerosis (MS). The objective of the present analysis was to prospectively evaluate the association of rotating night shift work history and MS risk in two female cohorts, the Nurses’ Health Study (NHS) and NHSII.MethodsA total of 83 992 (NHS) and 114 427 (NHSII) women were included in this analysis. We documented 579 (109 in NHS and 470 in NHSII) incident physician-confirmed MS cases (moderate and definite diagnosis), including 407 definite MS cases. The history (cumulative years) of rotating night shifts (≥3 nights/month) was assessed at baseline and updated throughout follow-up. Cox proportional hazards models were used to estimate HRs and 95% CIs for the association between rotating night shift work and MS risk adjusting for potential confounders.ResultsWe observed no association between history of rotating night shift work and MS risk in NHS (1–9 years: HR 1.03, 95% CI 0.69 to 1.54; 10+ years: 1.15, 0.62 to 2.15) and NHSII (1–9 years: HR 0.90, 95% CI 0.74 to 1.09; 10+ years: 1.03, 0.72 to 1.49). In NHSII, rotating night shift work history of 20+ years was significantly associated with MS risk, when restricting to definite MS cases (1–9 years: HR 0.88, 95% CI 0.70 to 1.11; 10–19 years: 0.98, 0.62 to 1.55; 20+ years: 2.62, 1.06 to 6.46).ConclusionsOverall, we found no association between rotating night shift work history and MS risk in these two large cohorts of nurses. In NHSII, shift work history of 20 or more years was associated with an increased risk of definite MS diagnosis.
Effect of user puffing topography on total particulate matter, nicotine and volatile carbonyl emissions from narghile waterpipes
Authors: Eddingsaas Nathan C , Hensel Edward C , O'Dea Sean , Kunselman Peyton , DiFrancesco A Gary , Robinson Risa J 
Published: August 2019

ObjectivesPuffing topographies of waterpipe users vary widely as does the puff-to-puff topography of an individual user. The aim of this study was to determine if puff duration and flow rate have an effect on the characteristics of the mainstream emission from waterpipes, including total particulate matter (TPM), mass ratio of nicotine and mass concentration of volatile carbonyls.MethodsPuffing parameters were chosen to encompass a significant portion of the perimeter space observed from a natural environment study. Tested conditions were 150, 200 and 250 mL sec-1; each run at 2, 3.5 and 5 s durations; 25 s interpuff duration and ~100 puffs per session. Each session was run in quadruplicate using the Programmable Emissions System-2 (PES-2) emissions capture system under identical conditions. Particulate matter, for quantification of TPM and nicotine, was collected on filter pads every ~5 L of aerosol resulting in 6 to 25 samples per session. Volatile carbonyls were sampled using 2,4-Dinitrophenylhydrazine (DNPH)-coated silica.ResultsMass concentration of TPM linearly decreased with increased flow rate, with no dependency on puff duration. Nicotine mass ratio was independent of topography, with average mass ratio of nicotine to TPM of 0.0027±0.0002 (mg/mg). The main carbonyls observed were acetaldehyde and formaldehyde. Puff duration increased emissions of some carbonyls (eg, formaldehyde) but not others (eg, acetaldehyde).ConclusionsThe results presented here highlight that topographies influence the emissions generated from waterpipes including TPM, total nicotine and volatile carbonyls. For laboratory studies to be representative of user exposure, a range of topographies must be studied. Using a range of topographies within a controlled laboratory environment will better inform regulatory policy.
A 6.5-kV HBM ESD-protected high-gain LNA using cascaded L-match input network
Authors: Cheng Guoxiao , Li Zhiqun , Yue Pengfei , Luo Lei , He Xiaodong , He Boyong 
Published: August 2019

A wideband (2–3 GHz) three-stage low noise amplifier (LNA) with electrostatic discharge (ESD) protection circuits using 0.18 [Formula: see text]m CMOS technology is presented in this paper. Low-parasitic silicon-controlled rectifier (SCR) devices are co-designed with the LNA in the form of [Formula: see text]-parameters, and a new cascaded L-match input network is proposed to reduce the parasitic effects of them on the input matching. To improve linearity performance, an optimized multiple-gated transistors method (MGTR) is proposed and applied to the third stage, which takes both transconductance [Formula: see text] and third-order nonlinear coefficient [Formula: see text] into consideration. The measured results show a wide input matching across 2–8 GHz and a high third-order input intercept point (IIP3) of −12.8 dBm. The peak power gain can achieve 29.1 dB, and the noise figure (NF) is in a range of 3.1–3.6 dB within the 3-dB bandwidth. Using SCR devices with low parasitic capacitance of [Formula: see text]80 fF and robust gate-driven power clamps, a 6.5-kV human body mode (HBM) ESD performance is obtained.
Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in KRAS-Mutant Cancer Cells
Authors: Erber Johanna , Steiner Joachim D. , Isensee Jörg , Lobbes Leonard A. , Toschka André , Beleggia Filippo , Schmitt Anna , Kaiser Rainer W. J. , Siedek Florian , Persigehl Thorsten , Hucho Tim , Reinhardt Hans C. 
Published: August 2019

Abstract

The advent of molecularly targeted therapeutic agents has opened a new era in cancer therapy. However, many tumors rely on nondruggable cancer-driving lesions. In addition, long-lasting clinical benefits from single-agent therapies rarely occur, as most of the tumors acquire resistance over time. The identification of targeted combination regimens interfering with signaling through oncogenically rewired pathways provides a promising approach to enhance efficacy of single-agent–targeted treatments. Moreover, combination drug therapies might overcome the emergence of drug resistance. Here, we performed a focused flow cytometry–based drug synergy screen and identified a novel synergistic interaction between GLUT1-mediated glucose transport and the cell-cycle checkpoint kinases ATR and CHK1. Combined inhibition of CHK1/GLUT1 or ATR/GLUT1 robustly induced apoptosis, particularly in RAS-mutant cancer cells. Mechanistically, combined inhibition of ATR/CHK1 and GLUT1 arrested sensitive cells in S-phase and led to the accumulation of genotoxic damage, particularly in S-phase. In vivo, simultaneous inhibition of ATR and GLUT1 significantly reduced tumor volume gain in an autochthonous mouse model of KrasG12D-driven soft tissue sarcoma. Taken together, these findings pave the way for combined inhibition of GLUT1 and ATR/CHK1 as a therapeutic approach for KRAS-driven cancers.

Significance:
Dual targeting of the DNA damage response and glucose transport synergistically induces apoptosis in KRAS-mutant cancer, suggesting this combination treatment for clinical validation in KRAS-stratified tumor patients.