bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co-initiation of continuous renal replacement therapy, peritoneal dialysis, and extracorporeal membrane oxygenation in neonatal life-threatening hyaline membrane disease
Authors: Li Guanhua , Zhang Li , Sun Yunxia , Chen Jimei , Zhou Chengbin 
Published: January 2019

Abstract

Rationale:
Extracorporeal membrane oxygenation (ECMO) is a well-known technique to provide cardio-pulmonary support. Although continuous renal replacement therapy (CRRT) is frequently indicated, the need for faster fluid removal as the primary indication for ECMO is uncommon. Experiences on concomitant applications of ECMO, peritoneal dialysis (PD) and CRRT in neonates are relatively limited.

Patient concerns:
We report a 2-day-old male neonate with life-threatening hyaline membrane disease (HMD), accompained by severe systemic fluid retention, sepsis and abdominal compartment syndrome.

Diagnosis:
Hyaline membrane disease (HMD), neonatal respiratory distress syndrome, sepsis, capillary leakage syndrome, and abdominal compartment syndrome.

Intervention:
Veno-arterial ECMO, CRRT, and PD were synchronously initiated for the sake of faster fluid removal possible.

Outcomes:
The infant was successfully weaned from ECMO circuit and fluid overload was greatly improved four days after extracorporeal life support (ECLS), without major complications.

Lessons:
Initiation of CRRT and PD during ECMO therapy is effective and safe to release fluid overload in neonates, and severe complications are absent. When a neonate requires dialysis of urgency, ECMO offers assured vascular access to hemodialysis, allowing faster fluid removal.
Combined treatment with vacuum sealing drainage, TopClosure device, and Ilizarov technique for traumatic hemipelvectomy
Authors: Li Jin , Shi Jie Bao , Hong Pan , Wang Yu Shang , Ze Hao Ren , Lee Rushyuan Jay , Tang Xin 
Published: January 2019

Abstract

Rationale:
Traumatic hemipelvectomy is a rare but lethal catastrophic injury.

Patient concerns:
A case of a very young child with open fracture of left sacroiliac joint dislocation and pubic symphysis diastasis, suffered from a severe large-size soft tissue defects.

Diagnosis:
Traumatic hemipelvectomy.

Interventions:
Complete amputation was performed and three kinds of surgical techniques including regulated negative pressure-assisted wound therapy (RNPT), TopClosure device, and Ilizarov technique were jointly utilized to secure closure in the further revisions of the soft tissue injury and reconstruct reconstructive surgery.

Outcomes:
Six months after hospital discharge, the patient was able to ambulate with a single limb and a prosthesis and she is independent in many activities of daily living currently.

Lessons:
We report this case to share experience with other clinicians in the management of this deadly extensive defects after traumatic hemipelvectomy in patients.
Acupuncture treatment on idiopathic trigeminal neuralgia
Authors: Liu Hao , Li Xin-Wei , Du Jia 
Published: January 2019

Abstract

Introduction:
The objective of this systematic review protocol is to provide the methods for evaluating the effectiveness and safety of acupuncture on the treatment of idiopathic trigeminal neuralgia (ITN).

Methods and analysis:
We will search randomized controlled trials (RCTs) on this subject in 8 electronic databases and they are Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), the Wan-Fang Database, and Chinese Scientific Journal Database (VIP database). Other relevant literatures will be manually searched as a complement. Only RCTs related to acupuncture for ITN in English or Chinese will be included, without limitation of publication types. The risk of bias and trial quality will be assessed by the Cochrane collaboration's tool. All data will be analyzed by RevMan V.5.3.3 statistical software.

Ethics and dissemination:
Ethical approval is not necessary as this paper does not involve patient data. This protocol will be disseminated by a peer-review journal or conference presentation.

Trial registration number:
PROSPERO CRD42015022173

Strengths and limitations of this study:
This systematic review will evaluate the effectivity and safety of acupuncture treatment on idiopathic trigeminal neuralgia. Two authors will perform independently study selection, data extraction and quality assessment, in order to ensure that all included studies are not personal bias. The result of this systematic review may give clinicians more ways to assist patient in relieving trigeminal neuralgia.
This shortage of systematic review is due to language barriers, only 2 languages of the trials can be included, other related studies may be missing. Different methods of acupuncture and quality of methodologies may result in essential heterogeneity.
Screening of common genetic variants in the APOB gene related to familial hypercholesterolemia in a Saudi population
Authors: Batais Mohammed Ali , Almigbal Turky H. , Shaik Noor Ahmad , Alharbi Fawaziah Khalaf , Alharbi Khalid Khalaf , Ali Khan Imran 
Published: January 2019

Abstract
Familial hypercholesterolemia (FH) is a monogenic dominant inherited disorder of lipid metabolism characterized by elevated low-density lipoprotein levels, and is mainly attributable to mutations in low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), and proportein convertase subtilisin/kexin type 9 (PCSK9) genes. Next-generation and exome sequencing studies have primarily involved genome-wide association analyses, and meta-analyses and next-generation studies examined a few single-nucleotide polymorphisms (rs151009667 and Val2095Glu) in the ApoB gene. The present study was conducted to investigate the association of APOB and patients with FH in a Saudi population.
We genotyped 100 patients with FH and 100 controls for 2 polymorphisms in APOB using polymerase chain reaction-restriction fragment length polymorphism, followed by 3% agarose gel electrophoresis. The strength of the association between the genotype and allele frequencies with the risk of developing FH was evaluated. Clinical details and genotype analysis results were recorded.
For the rs151009667 polymorphism, 18% of the CT genotypes were observed only in patients with FH. There was a positive association between CT and CC (odds ratio [OR] 45.07 [95% conflict of interest (CI), 2.67–759.1]; P = .0001) and between T and C (OR 87.8 [95% CI, 5.34–144.2]; P < .0001). However, no Val2095Glu mutations were found in patients with FH or controls. There was also no correlation between clinical characteristics and the rs151009667 polymorphism.
In conclusion, we confirmed the association between the rs151009667 polymorphism and FH in a Saudi population. The Val2095Glu novel variant did not appear in either patients with FH or controls. Similar studies should be performed in different ethnic populations to rule out the role of this polymorphism in FH.
Improvement in quality of life of Chinese chronic heart failure patients with neuropsychiatric complications over 12-months post-treatment with metoprolol
Authors: Zhang Ran , Huang Jingjing , Shu Qiuhong , Wu Liyong , Zhang Qian , Meng Yong 
Published: January 2019

Abstract
Psychological disorders, such as depression and anxiety, are known to be associated with chronic heart failure (CHF). The present study was conducted to evaluate the effect of mental status on quality of life (QoL) in metoprolol treated CHF patients with depression, anxiety, and burn-out.
This single-center prospective study was conducted between February 2013 and April 2016, enrolled CHF patients (resting heart rate >80 bpm) with depression, anxiety, and burn out at baseline. Hospital anxiety and depression scale (HADS) and Copenhagen burnout inventory (CBI) were used to assess the depression–anxiety status and burn-out status, respectively. Change in QoL was evaluated as the endpoint at 1st, 3rd, 6th, and 12th month from baseline using Minnesota Living with Heart Failure Questionnaire (MLHFQ) and short form-8 (SF-8) scales. A student t test was used to determine the change and P value < .05 was considered statistically significant. One hundred fifty-four patients were enrolled (median age 66 years; 65.58% males) and divided into 8 groups based on the HADS and CBI scores at baseline. Overall, the mean SF8 score and MLHFQ scores in different mental status groups showed a significant improvement (P < .05) in QoL from baseline to 12th month, with no significant difference reported between the groups. With regard to the follow-up periods, there was a deterioration in QoL until 3rd month, after which there was a significant improvement (P < .05).
There was a significant improvement in QoL in metoprolol treated CHF patients with depression, anxiety, and burn-out.
The association between ambient air pollution and birth defects in four cities in Hunan province, China, from 2014 to 2016
Authors: Xiong Lili , Xu Zenghui , Wang Hua , Liu Zhiyu , Xie Donghua , Wang Aihua , Kong Fanjuan 
Published: January 2019

Abstract
This study was performed to assess whether air pollution was positively associated with birth defects and if a specific pregnancy stage played a role. This was a population-based case-control study comprising 153,822 perinatal births in four cities located in Hunan province, China, during the period 2014 to 2016. Exposure to SO2, NO2, and PM10 in each pregnant woman in the first 3 months before pregnancy, and in the first and third trimester was assessed. The risk of birth defects related to SO2 in the first 3 months before pregnancy was between 1.191 and 1.566. In the first trimester stage the risk was between 1.104 and 1.348. The risk of birth defects related to NO2 before pregnancy was 1.285 (95%CI: 1.180–1.399), in the first trimester stage the risk was between 1.280 (95%CI: 1.197–1.368) and 1.380 (95%CI: 1.293–1.473). In the third month before delivery the risk was 1.484 (95%CI: 1.366–1.613). The risk of birth defects related to PM10 in the first month of pregnancy was 1.098 (95%CI: 1.057–1.140), and in the third month before delivery the risk was 1.296 (95%CI: 1.222–1.375). SO2 had a greater effect on the prophase of pregnancy, while NO2 and PM10 had an effect in the late third trimester.
Pelvic lipomatosis with ureteral calculi managed by flexible ureteroscopy
Authors: Yang Lei , Tang Wei 
Published: January 2019

Abstract

Rationale:
Pelvic lipomatosis (PL) is a benign disease characterized by overgrowth of adipose tissue in pelvic space. Hydronephrosis and ureterectasis are common complications caused by PL in urinary system. But PL accompanied with upper urinary tract calculi is rare. Also there has been no report of PL with ureteral calculi managed by flexible ureteroscopy (fURS).

Patient concerns:
A 62-year-old man who has been diagnosed of PL was found to have a right-side ureteral calculi by ultrasound in the routine health examination. In addition, the patient has a history of open surgery of uretero-vesical reimplantation in the left side 13 years ago because of heavy hydronephrosis in the left side.

Diagnoses:
The diagnosis was PL with ureteral calculi in the right side and heavy hydronephrosis in the left side.

Interventions:
FURS was performed to remove the right ureteral calculi.

Outcomes:
A follow-up of 1 year showed that there was no progression of the hydronephrosis in right side and serum creatinine was stable.

Lessons:
FURS is a suitable option for the upper urinary tract calculi accompanied with anatomical abnormality such as horseshoe kidney, pelvic ectopic kidney and so on. For patient of PL accompanied with upper urinary tract calculi, fURS is suitable and indicated.
Efficacy and safety of herbal medicine (Bailemian capsule) for treating insomnia
Authors: Tian Tian , Hua Lian , Wang Jianxin , Guan Jingzhi 
Published: January 2019

Abstract

Background:
Insomnia has become a universal subhealth disease, affecting more and more modern people's health and quality of life. At present, western medicine is only symptomatic treatment for insomnia. Bailemian Capsule (BLMC) is a proprietary Chinese medicine for treating insomnia. It has been widely used in China, but lacks evidence for evidence-based medicine. At the same time, the clinical efficacy and safety of BLMC are controversial. Therefore, the effectiveness and safety of BLMC in the treatment of insomnia are studied and systematically evaluated in this study. It provides reliable theoretical support for the treatment of insomnia with Traditional Chinese Medicine and the combination of traditional Chinese and Western medicine.

Methods:
The information was retrieved from electronic databases, Cochrane, PubMed, EMBASE, SinoMed, China National Knowledge Infrastructure, VIP Data, and WangFang Data. Randomized controlled trials on the BLMC in the treatment of insomnia were conducted. There was no limitation on the literature language. RevMan 5.3 software and STATA 12.0 software were used to perform the meta-analysis.

Results:
This review will be to assess the efficacy and safety of BLMC for insomnia.

Conclusion:
Our systematic evaluation will provide evidence for the clinical efficacy and safety of BLMC in the treatment of insomnia, and will be published in the form of academic papers in the future to provide new ideas for clinicians in the treatment of insomnia.
Co-outbreak of multidrug resistance and a novel ST3006 Klebsiella pneumoniae in a neonatal intensive care unit
Authors: Chen Dongjie , Hu Xinlan , Chen Falin , Li Hongru , Wang Daxuan , Li Xiaoqin , Wu Changsheng , Li Ning , Wu Shaolian , Li Zhen , Chen Liqing , Chen Yusheng 
Published: January 2019

Abstract
The outbreak of carbapenem-resistant Klebsiella pneumoniae is a serious public health problem, especially in the neonatal intensive care unit (NICU).
Fifteen K. pneumoniae strains were isolated from 7 neonates during June 3 to 28, 2017 in an NICU. Antimicrobial susceptibility was determined by the Vitek 2 system and microbroth dilution method. Multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE) were used to analyze the genetic relatedness of the isolates. Whole-genome sequencing and gene function analysis were performed to investigate pathogenicity and drug resistance and screen genomic islands.
Three clones of K. pneumoniae were identified from 7 neonates: 7 strains of ST37, 7 of novel ST3006, and 1 of ST1224. Gene sequencing showed that the kpn1343 (ST37) strain harbored 12 resistance genes (OXA-33, TEM-1, SHV-11, AAC (6’)-IId, AAC (3)-IIa, AAC (6’)-Ib-cr, catB3, arr-3, sul1, oqxB, oqxA, CRP, and catB3) and included 15 genomic islands and 205 reduced virulence genes. The kpn1344 (ST3006) strain harbored 4 antibiotic-resistant genes (TEM-1, CTX-M-3, vgaC, and CRP) and included 19 genomic islands and 209 reduced virulence genes. MLST and PFGE showed that 15 strains of K. pneumoniae were divided into 3 groups with a high level of homology. ST1224 (kpn1362) was isolated on June 28, 2017, which was 10 days after the last isolate (kpn1359, June 18, 2017); thus, we speculated that ST1224 was not the clone that caused the outbreak.
This co-outbreak of K. pneumoniae involved 2 clones: ST37 and ST3006. ST37 carried the multidrug-resistant genes, such as OXA-33, TEM-1, and SHV-11, and ST3006 was a novel K. pneumoniae ST typing. Whole-genome sequencing may be an effective method for screening bacterial-resistant genes and their functions.
Pregnancy Incidence and Fertility Desires Among Couples by HIV Status in Rakai, Uganda
Authors: Brahmbhatt Heena , Santelli John , Kaagayi Joseph , Lutalo Tom , Serwadda David , Makumbi Frederick 
Published: January 2019

Background:
The desire for more children and pregnancy rates are influenced by many relationship dynamics and HIV serostatus of couples.

Setting:
Rakai Community Cohort Study in Uganda.

Methods:
Couple data were retrospectively linked from survey rounds between 2007 and 2015 to assess drivers of fertility desire and pregnancy incidence by HIV status (M−F−; M+F+; M−F+; and M+F−). Multivariable modified Poisson regression was used to estimate prevalence ratios of fertility desire, whereas multivariable Poisson regression was used to estimate incidence rate ratios of pregnancy associated with couple characteristics.

Results:
Six thousand six hundred forty-seven couples contributed to 7656 person-years. Approximately 40% of couples (where at least 1 HIV+) desired more children. Unmet need for family planning was evident; couples of medium or low Socioeconomic status and with coresident children had lower fertility desires but higher pregnancy rates. Older age, being in a polygamous union, and having a HIV+ spouse in care were associated with lower fertility desire while having an older male partner was associated with higher fertility desire. Pregnancy incidence was lower with older age, among women using hormonal contraception and condoms, HIV+ concordant couples and couples where the HIV+ spouse was in care while pregnancy incidence were higher among women who desired more children, and serodiscordant couples (M−F+).

Conclusions:
There are many drivers of fertility desires and pregnancy rates, and HIV does not diminish the desire for more children. Unmet need for family planning was evident and highlighted the need to understand and meet the contraceptive needs of couples.
What Types of Physical Function Predict Program Adherence in Older Adults?
Authors: Liu Minhui , Miyawaki Christina E. 
Published: January 2019

Abstract

Purpose
The aims of this study were to describe participants’ demographic characteristics by adherence levels and to examine the association between participants’ baseline physical function and their adherence to an evidence-based group exercise program.

Design
A prospective exploratory study (N = 36,373).

Methods
Participants’ physical function was assessed using 30-second chair-stand, arm-curl, and 8-foot up-and-go tests. Adherence was calculated as the proportion of attended sessions over offered sessions.

Findings
Participants’ mean adherence was 52%. Older male, Asian/Pacific Islander race, and Washington State residents with fewer chronic conditions showed higher adherence. Multinomial logistic regression showed the baseline 30-second chair-stand, arm-curl, and 8-foot up-and-go tests significantly predict adherence levels after controlling for demographics.

Conclusions
Stronger upper- and lower-extremity strength and better walking balance and mobility are associated with higher adherence to exercise programs in older adults.

Clinical Relevance
The results underscored the importance of offering classes at various physical function levels while considering participants’ individual needs.
Cholinesterase Inhibitors May Not Benefit Mild Cognitive Impairment and Mild Alzheimer Disease Dementia
Authors: Han Jee-young , Besser Lilah M. , Xiong Chengjie , Kukull Walter A. , Morris John C. 
Published: January 2019

Introduction:
We investigated whether cholinesterase inhibitors (ChEIs) benefit cognitive outcomes in mild cognitive impairment due to Alzheimer disease (MCI-AD) and in mild AD dementia (ADdem).

Methods:
Data from 2242 individuals, clinically diagnosed with MCI-AD [Clinical Dementia Rating (CDR), 0 or 0.5] or with mild ADdem (CDR, 0.5 or 1), were available from the National Alzheimer’s Coordinating Center’s (NACC) Uniform Data Set (UDS). General linear mixed models were used to examine the annual change in the CDR Sum of Boxes (CDR-SB) and in neuropsychological performance. We compared slopes before and after ChEI initiation among ChEI users, and also compared the change in scores of ChEI users versus nonusers.

Results:
Thirty-four percent of 944 MCI-AD and 72% of 1298 ADdem participants were ChEI users. Cognitive decline was greater after ChEI initiation in MCI-AD and ADdem groups (eg, MCI-AD, CDR-SB: 0.03 points/y before initiation; 0.61 points/y after initiation, P<0.0001). Both MCI-AD and ADdem groups had faster decline after ChEI initiation than nonusers (eg, MCI-AD, CDR-SB: 0.61 points/y, ChEI users; 0.24 points/y, nonusers, P<0.0001).

Discussion:
This study suggests that ChEI use may not improve the cognitive course in MCI-AD and mild ADdem.
LAmbDA: Label Ambiguous Domain Adaption Dataset Integration Reduces Batch Effects and Improves Subtype Detection
Authors: Johnson Travis S , Huang Zhi , Yu Christina Y , Wang Tongxin , Wu Yi , Han Yatong , Hung Kun , Zhang Jie 
Published: January 2019

AbstractMotivationRapid advances in single cell RNA sequencing have produced more granular subtypes of cells in multiple tissues from different species. There exists a need to develop rigorous methods that can i) model multiple datasets with ambiguous labels across species and studies and ii) remove systematic biases across datasets and species.ResultsWe developed a species- and dataset-independent transfer learning framework (LAmbDA) to train models on multiple datasets and applied our framework on scRNA-seq experiments. These models mapped corresponding cell types between datasets with inconsistent labels while simultaneously reducing batch effects. We achieved high accuracy in labeling cellular subtypes (weighted accuracy pancreas: 91%, brain: 78%) using LAmbDA Random Forest. LAmbDA Feedforward 1 Layer Neural Network achieved higher weighted accuracy in labeling cellular subtypes than CaSTLe or MetaNeighbor in brain (48%, 32%, 20% respectively). Furthermore, LAmbDA Feedforward 1 Layer Neural Network was the only method to correctly predict ambiguous cellular subtype labels in both pancreas and brain compared to CaSTLe and MetaNeighbor. LAmbDA is model- and dataset-independent and generalizable to diverse data types representing an advance in biocomputing.Availability:github.com/tsteelejohnson91/LAmbDAContact:kunhuang@iu.edu,jizhan@iu.edu
Simultaneous quantification of protein-DNA contacts and transcriptomes in single cells
Authors: Rooijers Koos , Markodimitraki Corina M. , Rang Franka J. , Vries Sandra S. de , Chialastri Alex , Luca Kim de , Mooijman Dylan , Dey Siddharth S. , Kind Jop 
Published: January 2019

AbstractThe epigenome plays a critical role in regulating gene expression in mammalian cells. However, understanding how cell-to-cell heterogeneity in the epigenome influences gene expression variability remains a major challenge. Here we report a novel method for simultaneous single-cell quantification of protein-DNA contacts with DamID and transcriptomics (scDamID&T). This method enables quantifying the impact of protein-DNA contacts on gene expression from the same cell. By profiling lamina-associated domains (LADs) in human cells, we reveal different dependencies between genome-nuclear lamina (NL) association and gene expression in single cells. In addition, we introduce the E. coli methyltransferase, Dam, as an in vivo marker of chromatin accessibility in single cells and show that scDamID&T can be utilized as a general technology to identify cell types in silico while simultaneously determining the underlying gene-regulatory landscape. With this strategy the effect of chromatin states, transcription factor binding, and genome organization on the acquisition of cell-type specific transcriptional programs can be quantified.