bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthognathic Surgery Has a Significant Positive Effect on Perceived Personality Traits and Perceived Emotional Facial Expressions in Subjects with Primary Maxillary Deficiency
Authors: Posnick Jeffrey C. , Kinard Brian E. 
Published: April 2019

Background:
Crowdsourcing is increasingly being used in medical research to obtain the opinion of laypeople. The investigators hypothesized that a layperson’s perception of a primary maxillary deficiency (PMD) dentofacial deformity (DFD) patient is more favorable after orthognathic surgery with regard to perceived personality traits and emotional facial expressions.

Methods:
The investigators implemented a survey, distributed through Amazon.com’s Mechanical Turk crowdsourcing platform, to compare 6 perceived personality traits and 6 perceived emotional traits before and >6 months after orthognathic surgery in subjects through standardized facial photographs. The sample was composed of 20 subjects randomly selected from a PMD DFD database, treated by 1 surgeon all having undergone bimaxillary and chin orthognathic surgery. The outcome variable was change in each of 6 perceived personality and 6 emotional expression traits studied. Descriptive and bivariate statistics were computed. P-value of <0.05 was considered significant.

Results:
Five hundred respondents (raters) completed the survey. A majority of respondent raters were male (59%) and White (71%), ranging in age between 25 and 34 years (52%). After bimaxillary and chin orthognathic surgery, PMD subjects as a group were perceived to be significantly more dominant, more trustworthy, more friendly, more intelligent, more attractive, and less threatening. They were also perceived as happier and less angry, less surprised, less sad, less afraid, and less disgusted than before surgery (P < 0.05).

Conclusions:
We confirmed that laypeople consistently report positive changes in a PMD DFD subject’s perceived personality traits and perceived emotional expressions after bimaxillary and chin orthognathic surgery.
Clinical Outcomes of Lifitegrast 5% Ophthalmic Solution in the Treatment of Dry Eye Disease
Authors: Tong Amy Y. , Passi Samuel F. , Gupta Preeya K. 
Published: April 2019

Purpose:
To evaluate the clinical characteristics, outcomes, and adverse reactions after the use of lifitegrast 5% ophthalmic solution for the treatment of patients with dry eye disease (DED).

Methods:
Retrospective chart review was performed in 121 patients seen at the Duke Eye Center with DED who were prescribed lifitegrast 5% and seen for follow-up after treatment initiation. Charts were reviewed for meibomian gland dysfunction (MGD) grading, conjunctival and corneal staining scores, and tear breakup time (TBUT), as well as matrix metalloproteinase-9 (MMP-9) levels. Ocular Surface Disease Index (OSDI) questionnaire scores and self-reported adverse reactions were also assessed.

Results:
The average patient age was 60.5 years (range, 22–88 years); 87.6% were female, and 20.7% had a previous autoimmune disease diagnosis. Of the 54 eyes with an initial positive MMP-9, 21 eyes (38.9%) normalized after treatment. The ocular symptoms OSDI subscore demonstrated an improvement of −2.43±6.85 (P=0.011) after treatment. Corneal staining scores showed an average change of −0.15 (P=0.007). The average change in TBUT was 1.9 sec (P<0.001). Self-reported adverse reactions were noted in 31.4% of patients. There was no statistically significant change in MGD grading. Patients with moderate-severe DED showed statistically significant improvements in conjunctival and corneal staining scores and TBUT (−0.17±0.66, P=0.0442; −0.54±0.65, P<0.001; +2.02±2.63, P=0.004, respectively).

Conclusion:
Lifitegrast 5% is a useful therapeutic option for DED with a moderate proportion of self-reported adverse reactions, all of which were related to ocular discomfort. Treatment with lifitegrast was associated with statistically significant improvements in MMP-9 levels, ocular symptoms, corneal staining, and TBUT.
Comparative Study Between β-Lactam/β-Lactamase Inhibitors as Alternatives for Carbapenems in the Treatment of Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae
Authors: Hatem Amer Wesam , Abdel Rahman Elshweikh Samah , Mohammad Hablas Nahed 
Published: April 2019

Background
In the era of the increase in carbapenem resistance, searching for alternative drugs becomes mandatory. In this study, an in vitro activity of β-lactam/β-lactamase inhibitors against extended-spectrum β-lactamase–producing Enterobacteriaceae (ESBL-PE) isolated from bloodstream infections was investigated.

Methods
Blood samples were collected from patients with bloodstream infections in both pediatric and internal medicine intensive care units of Tanta University Hospitals, Egypt. BacT/ALERT was used, and positive blood cultures were subcultured on MacConkey, blood, chocolate agar and then incubated at 5% to 10% CO2, 37°C for 24 hours. Identification of the bacterial isolates was performed by VITEK 2TM Compact 15. Susceptibility testing was performed for isolated Escherichia coli and Klebsiella species using Kirby-Bauer disk diffusion and minimum inhibitory concentration. E test strips were used for cefoperazone/sulbactam, ceftazidime/avibactam, and ceftolozane/tazobactam. All isolates that were resistant to third-generation cephalosporins as per Clinical and Laboratory Standards Institute recommendations were confirmed for ESBL detection by modified double-disk synergy test, VITEK2 system, and multiplex polymerase chain reaction.

Results
One hundred twenty-five Enterobacteriaceae were isolated; 100 of them (80%) were ESBL positive. The best used β-lactam/β-lactamase inhibitors were ceftazidime/avibactam and ceftolozane/tazobactam with lower minimum inhibitory concentration at which 50% of isolates are inhibited (≤0.016, 0.094 μg/mL, respectively) than that of meropenem (0.125 μg/mL), so they can be used as carbapenem sparers in the treatment of ESBL-PE to decrease the incidence of carbapenem resistance.

Conclusions
Ceftazidime/avibactam and ceftolozane/tazobactam can be used as carbapenem sparers in the treatment of ESBL-PE to decrease the incidence of carbapenem resistance.
A Comparison of Erysipelothrix rhusiopathiae Bacteremia With and Without Endocarditis in Frequent Fish Handlers
Authors: Hornak J. Patrik , McLean Maranatha R. , Webb Camille M. , Keiser Philip H. 
Published: April 2019

Abstract
A facultatively anaerobic gram-positive bacillus, Erysipelothrix rhusiopathiae is widely present in the environment and also as a commensal and pathogenic organism associated with livestock, birds, and fish. Invasive infections in humans are rare, classically affect patients with exposures to animal products, and frequently progress to include endocarditis. Here we present our successful experience of treating 2 patients with E. rhusiopathiae bacteremia, both frequently exposed to fish. One patient presented in new-onset heart failure after a protracted illness and was found to have subacute aortic and mitral valve endocarditis successfully treated with surgical valve replacement and prolonged intravenous penicillin therapy. The other patient had acute uncomplicated bacteremia responsive to ceftriaxone followed by step-down treatment with oral penicillin, the first published report using such regimen. Our experience highlights the spectrum of clinical disease seen in E. rhusiopathiae bacteremia and offers new perspectives to optimize treatment for these patients.
Priority setting in otolaryngology practices in Zimbabwe
Authors: Chidziva Clemence , Soko Nyarai D. 
Published: April 2019

Purpose of review
This article describes priority setting in otorhinolaryngology healthcare services in Zimbabwe. It aims to initiate discussion on priority setting among otorhinolaryngologists working in African countries.

Recent findings
The WHO reports that most developed countries have formal processes in place for the collection and analysis of information that is used in priority setting in healthcare services. However, many resource-limited nations lack well-defined processes for priority setting. Information surrounding priority setting in otorhinolaryngology in particular is scarce.

Summary
Priority setting refers to the distribution of limited resources among competing programmes and patient or patient groups in an equitable and just manner. A dearth of information on priority setting in otorhinolaryngology exists. This silence is more pronounced in African settings. Despite the myriad of challenges facing many African countries, formal guidelines for priority setting are rare. Priority setting therefore is often haphazard and unplanned. We therefore recommend agility in bringing together otorhinolaryngology stakeholders in an effort to initiate dialogue and come up with formal processes that will collect information that will lead to provision of guidelines in priority setting.
A Systematic Review of the Association Between Bereavement and Biomarkers of Immune Function
Authors: Knowles Lindsey M. , Ruiz John M. , O'Connor Mary-Frances 
Published: April 2019

ABSTRACT

Objective
Bereavement is associated with increased risk for morbidity and all-cause mortality across epidemiological, meta-analytic, and case-control studies. The body of research examining the association between bereavement and immune function, beginning in 1977, has yet to be reviewed. The current systematic review clarifies these findings, identifies limitations of the diverse literature, and suggests a model and directions for future research.

Methods
The PRISMA guidelines for systematic reviews were used to synthesize 41 years of research. Compared with a meta-analysis, a systematic review is appropriate given the heterogeneous nature of the studies. We used the National Heart, Lung, and Blood Institute Study Quality Assessment Tool to assess the quality of select studies.

Results
Thirty-three publications met inclusion criteria. Most studies support the association between bereavement and maladaptive changes in immune parameters in adults, with mixed findings on bereavement-related changes in cellular immunity. A handful of recent, good-quality studies show bereaved people demonstrate higher levels of systemic inflammation, maladaptive immune cell gene expression, and lower antibody response to vaccination compared with nonbereaved controls. Individual differences in psychological response to bereavement (e.g., depression, grief) seem to influence the association between bereavement and immune function.

Conclusions
Research examining the association between bereavement and biomarkers of immune function is heterogeneous in methods and quality. Despite these limitations, there is evidence supporting maladaptive changes in immune function after bereavement. The research area would benefit from longitudinal research with larger sample sizes, advanced immunological methods, and incorporating measures of psychological responses to bereavement. The field is poised to refine and scale up its investigation of this common and important phenomenon.
Switching to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (DOR/3TC/TDF) Maintains HIV-1 Virologic Suppression Through 48 Weeks: Results of the DRIVE-SHIFT Trial
Authors: Johnson Margaret , Kumar Princy , Molina Jean-Michel , Rizzardini Giuliano , Cahn Pedro , Bickel Markus , Mallolas Josep , Zhou Yan , Morais Cristiana , Kumar Sushma , Sklar Peter , Hanna George J. , Hwang Carey , Greaves Wayne ,   for the DRIVE-SHIFT Study Group
Published: April 2019

Background:
Doravirine is a novel, nonnucleoside reverse transcriptase inhibitor with demonstrated efficacy in treatment-naive adults with HIV-1.

Methods:
In this open-label, active-controlled, noninferiority trial, adults with HIV-1 virologically suppressed for ≥6 months on 2 nucleoside reverse transcriptase inhibitors plus a boosted protease inhibitor, boosted elvitegravir, or a non-nucleoside reverse transcriptase inhibitor were randomized (2:1) to switch to once-daily, single-tablet doravirine 100 mg with lamivudine 300 mg and tenofovir disoproxil fumarate 300 mg (DOR/3TC/TDF) or to continue their current therapy (Baseline Regimen) for 24 weeks. The primary endpoint was the proportion of participants with HIV-1 RNA <50 copies/mL (defined by the FDA Snapshot approach), with the primary comparison between DOR/3TC/TDF at week 48 and Baseline Regimen at week 24 and a secondary comparison between the groups at week 24 (noninferiority margin, −8%).

Results:
Six hundred seventy participants (447 DOR/3TC/TDF, 223 Baseline Regimen) were treated and included in the analyses. At week 24, 93.7% on DOR/3TC/TDF vs 94.6% on Baseline Regimen had HIV-1 RNA <50 copies/mL [difference −0.9 (−4.7 to 3.0)]. At week 48, 90.8% on DOR/3TC/TDF had HIV-1 RNA <50 copies/mL, demonstrating noninferiority vs Baseline Regimen at week 24 [difference −3.8 (−7.9 to 0.3)]. In participants on ritonavir-boosted protease inhibitor at entry, mean reductions in fasting LDL-C and non-HDL-C at week 24 were significantly greater for DOR/3TC/TDF vs Baseline Regimen (P < 0.0001). Adverse events occurred in 68.9% on DOR/3TC/TDF and 52.5% on Baseline Regimen by week 24, leading to treatment discontinuation in 2.5% and 0.4%, respectively.

Conclusions:
Switching to once-daily DOR/3TC/TDF is a generally well-tolerated option for maintaining viral suppression in patients considering a change in therapy.

Registration:

ClinicalTrials.gov NCT02397096.
A Rare Case of Primary Endometrial Hepatoid Adenocarcinoma on 18F-FDG PET/CT
Authors: Yin Hongyan , Hu Yan , Xiu Yan , Luo Rongkui , Shi Hongcheng 
Published: April 2019

Abstract
Primary endometrial hepatoid adenocarcinoma is a rare tumor. We present a case of a 64-year-old woman with vaginal bleeding for 2 months and a markedly elevated serum α-fetoprotein of 3931 ng/mL. Hysteroscopic segmental curettage revealed endometrial adenocarcinoma. A pelvic MRI was performed for local tumor invasion, which showed only endometrial mass. An abdominal enhanced CT showed no liver lesion, which excluded primary hepatic carcinoma. Staging 18F-FDG PET/CT demonstrated a hypermetabolic mass in the endometrium. A total hysterectomy with bilateral salpingo-oophorectomy and regional lymphadenectomy were performed. Postoperatively, the mass was diagnosed as primary endometrial hepatoid adenocarcinoma.
68Ga–Prostate-Specific Membrane Antigen PET/CT in Cholangiocarcinoma
Authors: Marafi Fahad , Usmani Sharjeel , Esmail Abdulredha 
Published: April 2019

Abstract

68Ga-PSMA is a promising tracer for both staging and detection of biochemical recurrence in prostate cancer. Prostate-specific membrane antigen is also expressed in the endothelium of neovasculature of various solid malignancies possibly due to tumor-associated angiogenic factors and endothelial cell sprouting. We report a case of 75-year-old man with metastatic cholangiocarcinoma to liver and lymph nodes progressing on chemotherapy. 68Ga-PSMA PET/CT was performed to assess PSMA expression and showed additional bone and hepatic lesions compared with 18F-FDG PET/CT. 68Ga-PSMA expression in the metastatic cholangiocarcinoma potentially guides radionuclide legend therapy with α/β-emitters especially after enervation of all approved therapeutic options.
Isolated Vaginal Recurrence of Early-Stage Rectal Cancer Detected by 18F-FDG PET/CT
Authors: Wang Rang , Fan Qiuping , Liu Huiting , Su Minggang 
Published: April 2019

Abstract
The relapses of rectal cancer are most frequently localized in the pelvis, liver, and pelvic and para-aortic lymph nodes and lungs, whereas the vagina is an unusual site. We present here a 60-year-old woman presenting with lower abdominal discomfort 23 months after radical resection of rectal adenocarcinoma. An isolated, solitary, hypermetabolic mass in the right part of the vagina was detected by 18F-FDG PET/CT. Ultimately, the vaginal neoplasm was proved to be adenocarcinoma of rectal origin based on its shared histologic features and compatible immunostaining profile.
Aberrant Hypermetabolism of Benign Uterine Leiomyoma on 18F-FDG PET/CT
Authors: Nunes Rafael F. , Queiroz Marcelo A. , Buchpiguel Carlos Alberto , Carvalho Filomena Marino , Carvalho Jesus Paula 
Published: April 2019

Abstract
Leiomyomas are prevalent benign smooth muscle tumors in the uterus, displaying variable degrees of FDG uptake on PET/CT. The glucose metabolism intensity of those lesions relies on biologic features and markedly increased FDG accumulation is more typically related to malignant diseases, as in the case of leiomyosarcomas. Notwithstanding that uterine fibroids typically exhibit mild to moderate FDG uptake, in this article we report a case of unexpectedly intense hypermetabolism of a benign uterine leiomyoma on a PET/CT scan performed for initial staging of a breast cancer patient.
Optical properties of ice and snow
Authors: Warren Stephen G. 
Published: April 2019

The interactions of electromagnetic radiation with ice, and with ice-containing media such as snow and clouds, are determined by the refractive index and absorption coefficient (the ‘optical constants’) of pure ice as functions of wavelength. Bulk reflectance, absorptance and transmittance are further influenced by grain size (for snow), bubbles (for glacier ice and lake ice) and brine inclusions (for sea ice). Radiative transfer models for clouds can also be applied to snow; the important differences in their radiative properties are that clouds are optically thinner and contain smaller ice crystals than snow. Absorption of visible and near-ultraviolet radiation by ice is so weak that absorption of sunlight at these wavelengths in natural snow is dominated by trace amounts of light-absorbing impurities such as dust and soot. In the thermal infrared, ice is moderately absorptive, so snow is nearly a blackbody, with emissivity 98–99%. The absorption spectrum of liquid water resembles that of ice from the ultraviolet to the mid-infrared. At longer wavelengths they diverge, so microwave emission can be used to detect snowmelt on ice sheets, and to discriminate between sea ice and open water, by remote sensing. Snow and ice are transparent to radio waves, so radar can be used to infer ice-sheet thickness.
This article is part of the theme issue ‘The physics and chemistry of ice: scaffolding across scales, from the viability of life to the formation of planets’.
Microstructural characterization of snow, firn and ice
Authors: Baker Ian 
Published: April 2019

This paper provides an overview of techniques used to characterize the microstructure of snow, firn and ice. These range from traditional optical microscopy techniques such as examining thin sections between crossed polarizers to various electron-optical and X-ray techniques. Techniques that could have an impact on microstructural characterization of snow, firn and ice in the future are briefly outlined.This article is part of the theme issue ‘The physics and chemistry of ice: scaffolding across scales, from the viability of life to the formation of planets’.
Mushy-layer growth and convection, with application to sea ice
Authors: Wells Andrew J. , Hitchen Joseph R. , Parkinson James R. G. 
Published: April 2019

Sea ice is a reactive porous medium of ice crystals and liquid brine, which is an example of a mushy layer. The phase behaviour of sea ice controls the evolving material properties and fluid transport through the porous ice, with consequences for ice growth, brine drainage from the ice to provide buoyancy fluxes for the polar oceans, and sea-ice biogeochemistry. We review work on the growth of mushy layers and convective flows driven by density gradients in the interstitial fluid. After introducing the fundamentals of mushy-layer theory, we discuss the effective thermal properties, including the impact of salt transport on mushy-layer growth. We present a simplified model for diffusively controlled growth of mushy layers with modest cooling versus the solutal freezing-point depression. For growth from a cold isothermal boundary, salt diffusion modifies mushy-layer growth by around 5–20% depending on the far-field temperature and salinity. We also review work on the onset, spatial localization and nonlinear development of convective flows in mushy layers, highlighting recent work on transient solidification and models of nonlinear convection with dissolved solid-free brine channels. Finally, future research opportunities are identified, motivated by geophysical observations of ice growth.
This article is part of the theme issue ‘The physics and chemistry of ice: scaffolding across scales, from the viability of life to the formation of planets’.
Ice: the paradigm of wild plasticity
Authors: Weiss Jérôme 
Published: April 2019

Ice plasticity has been thoroughly studied, owing to its importance in glaciers and ice sheets dynamics. In particular, its anisotropy (easy basal slip) has been suspected for a long time, then fully characterized 40 years ago. More recently emerged the interest of ice as a model material to study some fundamental aspects of crystalline plasticity. An example is the nature of plastic fluctuations and collective dislocation dynamics. Twenty years ago, acoustic emission measurements performed during the deformation of ice single crystals revealed that plastic ‘flow’ proceeds through intermittent dislocation avalanches, power law distributed in size and energy. This means that most of ice plasticity takes place through few, very large avalanches, thus qualifying associated plastic fluctuations as ‘wild’. This launched an intense research activity on plastic intermittency in the Material Science community. The interest of ice in this debate is reviewed, from a comparison with other crystalline materials. In this context, ice appears as an extreme case of plastic intermittency, characterized by scale-free fluctuations, complex space and time correlations as well as avalanche triggering. In other words, ice can be considered as the paradigm of wild plasticity.This article is part of the theme issue ‘The physics and chemistry of ice: scaffolding across scales, from the viability of life to the formation of planets’.
Surface phase transitions in ice: from fundamental interactions to applications
Authors: Wettlaufer J. S. 
Published: April 2019

Interfaces divide all phases of matter and yet in most practical settings it is tempting to ignore their energies and the associated implications. There are many reasons for this, not the least of which is the introduction of a new pair of canonically conjugate variables—interfacial energy and its counterpart the surface area. A key set of questions surrounding the treatment of multiphase flows concerns how and when we must account for such effects. I begin this discussion with an abbreviated review of the basic theory of lower-dimensional phase transitions and describe a range of situations in which the bulk behaviour of a two-phase (and in some cases two-component) system is dominated by surface effects. Then I discuss a number of settings in which the bulk and surface behaviour can interact on equal footing. These can include the dynamic and thermodynamic behaviour of floating sea ice, the freezing and drying of colloidal suspensions (such as soil) and the mechanisms of protoplanetesimal formation by inter-particle collisions in accretion discs.
This article is part of the theme issue ‘The physics and chemistry of ice: scaffolding across scales, from the viability of life to the formation of planets’.