bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Survival Among Patients With Cancer by COVID-19 Vaccination Status: An Analysis of the ASCO COVID-19 Registry
Authors: Kirkwood M. Kelsey , Aggarwal Charu , Bruinooge Suanna S. , Williams Jen Hanley , Kaltenbaugh Melinda , Ramos Natalie , Gralow Julie R. , Garrett-Mayer Elizabeth 
Published: November 2024

PURPOSE
We evaluated our hypotheses that vaccine exposure before infection with SARS-CoV-2 in patients with cancer would be associated with overall survival and vaccine exposure would differ by patient demographics, area-level social determinants of health, and clinical features.

METHODS
Our cohort study includes patients with cancer 18 years and older who tested positive for SARS-CoV-2 infection on or after April 1, 2021, and had information on receipt (or not) of at least one COVID-19 vaccine dose. We analyzed three vaccine exposure categories reflecting recency of last dose before SARS-CoV-2 infection was defined: No dose, any recent dose (1-6 months), and last dose in >6 months. Patients with last dose in <1 month were categorized on the basis of previous dose (if present) or as no dose.

RESULTS
This cohort analysis included 1,765 patients with cancer diagnosed with COVID-19 disease between April 2021 and July 2023 (57% female, 68% non-Hispanic White, and 51% age <65 years). The following patient characteristics were associated with vaccination status: age, rurality, Eastern Cooperative Oncology Group performance status, cancer type, and COVID-19 diagnosis window, as well as quartiles of area-level median household income, percent unemployed, and percent high school-only graduates age >24 years. After adjusting for covariates, the hazard ratio for death was 1.60 times among patients with no dose (95% CI, 1.26 to 2.04) and 1.32 times among those with last dose in >6 months (95% CI, 1.03 to 1.69) compared with those with a dose 1-6 months before infection.

CONCLUSION
Our findings underscore the need for oncology-specific guidance on COVID-19 vaccination schedules and suggest that more frequent than annual administration of vaccination may be appropriate for patients with cancer.
Impact of Low Maternal Weight on Pregnancy and Neonatal Outcomes
Authors: Chahal Nikhita , Qureshi Tanya , Eljamri Soukaina , Catov Janet M , Fazeli Pouneh K 
Published: November 2024

Abstract

Objective
To examine the effect of underweight maternal body mass index (BMI) on pregnancy complications and neonatal outcomes.

Design
Cohort study.

Setting
Tertiary academic center.

Patients
A total of 16 361 mothers who delivered a singleton between 2015-2021 with either a BMI &lt;18.5 kg/m2 (n = 732) or normal BMI (18.5 ≥ BMI &lt;23 or 25 kg/m2, n = 15 629) at the initial prenatal visit or within 6 months of the initial visit.

Main Outcome Measures
Birthweight, gestational age, neonatal intensive care unit admission, preterm birth, and fetal death; obstetrical complications including preeclampsia/eclampsia, premature rupture of membranes, preterm premature rupture of membranes, and postpartum hemorrhage.

Results
Underweight women were younger and less likely to have private insurance (P &lt; .01 for both) than normal-weight women. Approximately 23% of infants born to underweight mothers were small for gestational age and 15% were low birth weight vs 13.5% and 9% of infants of normal-weight mothers, respectively (P &lt; .01 for both). These differences remained significant after adjusting for potential confounders. In adjusted logistic regression models, underweight women had a decreased risk of premature rupture of membranes and postpartum hemorrhage compared to normal-weight women.

Conclusion
Underweight BMI during pregnancy is associated with an increased risk of small for gestational age and low birth weight infants and a decreased risk of premature rupture of membranes and postpartum hemorrhage. These findings suggest underweight BMI during pregnancy increases the risk of adverse neonatal outcomes, while maternal-related pregnancy outcomes are less affected.
Phosphorylation on serine 72 modulates Rab7A palmitoylation and retromer recruitment
Authors: Modica Graziana , Tejeda-Valencia Laura , Sauvageau Etienne , Yasa Seda , Maes Juliette , Skorobogata Olga , Lefrancois Stephane 
Published: November 2024

ABSTRACT
Rab7A has a key role in regulating membrane trafficking at late endosomes. By interacting with several different effectors, this small GTPase controls late endosome mobility, orchestrates fusion events between late endosomes and lysosomes, and participates in the formation of and regulates the fusion between autophagosomes and lysosomes. Rab7A is also responsible for the spatiotemporal recruitment of retromer, which is required for the endosome-to-trans-Golgi network retrieval of cargo receptors such as sortilin (SORT1) and CI-MPR (also known as IGF2R). Recently, several post-translational modifications have been shown to modulate Rab7A functions, including palmitoylation, ubiquitination and phosphorylation. Here, we show that phosphorylation of Rab7A at serine 72 is important to modulate its interaction with retromer, as the non-phosphorylatable Rab7AS72A mutant is not able to interact with and recruit retromer to late endosomes. We have previously shown that Rab7A palmitoylation is also required for efficient retromer recruitment. We found that palmitoylation of Rab7AS72A is reduced compared to that of the wild-type protein, suggesting an interplay between S72 phosphorylation and palmitoylation in regulating the Rab7A–retromer interaction. Finally, we identify NEK7 as a kinase required to phosphorylate Rab7A to promote retromer binding and recruitment.
Varus Strength of the Medial Elbow Musculature for Stress Shielding of the Ulnar Collateral Ligament in Competitive Baseball Pitchers
Authors: Yanai Toshimasa , Onuma Kengo , Nagami Tomoyuki 
Published: November 2024

ABSTRACT

Purpose
Valgus load opens the medial elbow compartment, causing elongation of the ulnar collateral ligament (UCL) that can eventually lead to attenuation and failure. Ideally, the muscles surrounding the medial aspect of elbow joint should coordinate medial elbow compression to prevent the medial elbow compartment from opening and loading the UCL. This study aimed to determine whether baseball pitchers have sufficient elbow varus strength to unload the UCL during pitching.

Methods
Using an electromagnetic tracking device, we measured the peak elbow varus moment during pitches (fastball, slider, curveball, and changeup) by 14 professional and 8 collegiate pitchers. Elbow varus strength was measured with an isokinetic dynamometer system while the medial elbow joint space was monitored using ultrasonography. A paired t-test was used to compare the peak varus moment generated during pitching with the varus strength, and the relative intensity of muscular output required to unload the UCL was determined.

Results
Except for curveballs, the muscular varus strength (57.5 ± 9.2 N·m) was not significantly larger (p = 0.165 ~ 0.853) than the peak varus moments during pitching (55.4 ± 13.0 N·m). Ten participants did not have sufficient muscular varus strength to completely unload the UCL from valgus loading when throwing fastballs and other pitch types. The relative intensity of muscular torque output required for stress shielding of the UCL ranged from 89.1%MVIVS ±21.7%MVIVS for curveballs to 103.1%MVIVS ±26.5%MVIVS for fastballs.

Conclusions
Our findings demonstrate that most of the valgus load on the elbow joint during pitching can be counteracted by the muscular varus moment, but valgus loading on the UCL is likely unavoidable in baseball pitching.
Barriers and Predictors of Long-Term Physical Activity Maintenance: The STRRIDE I Reunion Cohort
Authors: Collins-Bennett Katherine A. , Ross Leanna M. , Johnson Johanna L. , Slentz Cris A. , Huffman Kim M. , Kraus William E. 
Published: November 2024

ABSTRACT

Introduction
This study aimed to identify barriers and predictors of self-reported physical activity (PA) maintenance 10 yr following the Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE I) randomized trial among young older adults.

Methods
Participants completed a PA recall questionnaire that assessed barriers to PA maintenance. Chi-square tests assessed differences in barriers by PA maintenance tertile. Demographic and clinical measures collected at baseline and post-intervention from the STRRIDE I parent trial were included in model development to identify predictors of PA maintenance. Three models were generated using a backward bootstrap variable selection algorithm followed by multiple linear regression.

Results
Participants who returned for the STRRIDE I Reunion study (n = 104; 63.0 ± 6.2 yr old) reported mean PA participation of 77.9 ± 76.5 min·wk−1. Commonly reported barriers to PA maintenance included lack of self-motivation (41%), time constraints (33%), illness or injury (29%), and family obligations (23%). There was a significant association between the percentage of individuals who reported one or more barriers versus no barriers by PA maintenance tertile (frequency of PA: χ
2 ratio = 26.1, P < 0.0001; amount of PA: χ
2 ratio = 15.1, P = 0.0005). The baseline predictive model had an adjusted R
2 value of 0.05, the post-intervention predictive model had an adjusted R
2 of 0.12, and the change score (post-intervention minus pre-intervention) predictive model had an adjusted R
2 of 0.17.

Conclusions
Maintaining PA beyond a structured exercise intervention setting continues to be challenging for older adults. Compared to those who reported no barriers, young older adults who reported one or more barriers to PA maintenance were less active 10 yr following STRRIDE I. Additionally, how participants respond to a structured exercise intervention in certain clinical variables may be the most indicative of future PA maintenance.
Exercise Is Medicine® On Campus: A National Analysis of the 2023 Recognized Programs
Authors: Lennox Isaac M. , Wedig Isaac J. , Kamm Kelly B. , Petushek Erich J. , Elmer Steven J. 
Published: November 2024

ABSTRACT

Introduction
For 15 yr, the Exercise is Medicine® On Campus (EIM-OC) initiative has called upon colleges and universities to promote physical activity on their campuses. To date, there are no reports describing the distribution of EIM-OC programs across the United States, and it is unclear what factors best position programs to achieve gold-level status. The purpose of this study was to perform a national analysis of the 2023 recognized EIM-OC programs.

Methods
We identified the locations of the EIM-OC programs (American College of Sports Medicine (ACSM) regional chapter, state, county, city) and described their characteristics (school size, presence of kinesiology-related degree program, type of healthcare services offered, presence of a medical school). Data were obtained from websites, and differences between bronze, silver, and gold recognition levels were assessed.

Results
Of the 131 EIM-OC programs, 19, 50, and 62 were bronze, silver, and gold levels, respectively. Thirty-seven states had at least one EIM-OC program, and 27 states had a gold-level program. The Southeast, Midwest, and Mid-Atlantic ACSM regional chapters had the most total (all ≥20) and gold-level (all ≥12) EIM-OC programs. Nearly 90% of total and gold-level EIM-OC programs were in metropolitan counties. Eighty-six percent of EIM-OC programs had a kinesiology-related degree program, 76% had student-centered health services on campus, and 28% had a medical school; however, there were no differences between bronze (P = 0.56), silver (P = 0.11), and gold (P = 0.12) levels. School (~215–68,000 students; P = 0.21), city (~690–2,700,000 people; P = 0.14), and county (~9,500–10,000,000 people; P = 0.32) populations for EIM-OC programs ranged considerably and did not differ across recognition levels.

Conclusion
In the United States, colleges and universities with a broad range of locations, sizes, and infrastructures have used EIM-OC to promote physical activity. A kinesiology-related degree program and student healthcare services on campus are key assets for implementation, regardless of recognition level. There are fewer EIM-OC programs in select states, ACSM regions, and non-metropolitan areas. These findings may guide future EIM-OC promotion and implementation.
ON THE PROBLEM OF CONTROL THE RELIABILITY OF AN INFORMATION SYSTEM UNDER CONDITIONS OF INTERVAL UNCERTAINTY
Authors: Kalashnikov Pavel V. 
Published: November 2024

In the course of the study, aspects of the power supply of information systems are considered in the case of uncertainty described by interval-type data, and the main types of errors that arise during their operation are studied.
The aim of the study is to find effective approaches to ensuring reliable operation of information systems subject to the presence of uncertainty in the values ​​of parameters specified by interval data.
Materials and methods. This article presents an approach to solving the problem of control the reliability of a complex information system in the presence of an uncertainty factor in the values ​​of parameters that can be described using interval type data and the corresponding mathematical methods for working with them
The scientific novelty of the described approach lies in the ability to most accurately take into account the error factor that occurs when an information system operates under conditions of uncertainty and determine the optimal options for correcting the values ​​of its parameters, without allowing their changes to go beyond the permissible intervals.
Conclusion. The approach proposed in the article is supposed to be used when solving the problem of ensuring reliable operation of an information system in the presence of uncertainty, which can be described using the apparatus of interval data. The developed method makes it possible to find the optimal control effect on the system parameters at a given time, at which the probability of failures will be minimized.
Obesity impact on bones and joints health
Authors: Mrugała Waldemar , Skierkowski Bartosz , Mrugała Sebastian , Muciek Michał , Kawka Jakub , Filipek Kinga , Czyżewski Filip , Baranowska Katarzyna , Baranowska Alicja , Zalewska Natalia 
Published: November 2024

Introduction and objective
Obesity, characterized by excessive fat accumulation, poses significant health risks. The WHO classifies overweight as a BMI of 25 to <30 kg/m² and obesity as a BMI of ≥30 kg/m², divided into three classes. This study examines the relationship between obesity and bone health, focusing on osteoarthritis (OA), rheumatoid arthritis (RA), and fracture risks.

Review methods

A review of epidemiological and clinical studies was conducted, including WHO statistics, U.S. obesity trends, and recent findings on the mechanisms linking obesity with bone health and joint diseases. Studies were selected for their relevance to understanding obesity's impact on skeletal health.

Abbreviated description of the state of knowledge

Obesity is influenced by sociodemographic, behavioral, and genetic factors. While excess weight was once considered beneficial for bones due to increased mechanical loading, recent research shows its harmful effects. Obesity is linked to chronic inflammation, altered adipokine levels, and higher risk of atypical fractures. In OA, obesity accelerates joint degeneration through mechanical and metabolic pathways. In RA, obesity is associated with increased disease activity and cardiovascular complications.

Summary

Obesity significantly affects bone and joint health, increasing the risk of OA, RA, and fractures. The paradox of obesity providing mechanical benefits while causing metabolic and inflammatory issues is crucial. Understanding these mechanisms is vital for developing effective prevention and management strategies for obesity-related skeletal diseases. Further research is essential to clarify the complex interactions between adipose tissue and bone health, aiming to improve outcomes for obese individuals.
QHDOPT: A Software for Nonlinear Optimization with Quantum Hamiltonian Descent
Authors: Kushnir Samuel , Leng Jiaqi , Peng Yuxiang , Fan Lei , Wu Xiaodi 
Published: November 2024

We develop an open-source, end-to-end software (named QHDOPT), which can solve nonlinear optimization problems using the quantum Hamiltonian descent (QHD) algorithm. QHDOPT offers an accessible interface and automatically maps tasks to various supported quantum backends (i.e., quantum hardware machines). These features enable users, even those without prior knowledge or experience in quantum computing, to utilize the power of existing quantum devices for nonlinear and nonconvex optimization tasks. In its intermediate compilation layer, QHDOPT employs SimuQ, an efficient interface for Hamiltonian-oriented programming, to facilitate multiple algorithmic specifications and ensure compatible cross-hardware deployment. The detailed documentation of QHDOPT is available at https://github.com/jiaqileng/QHDOPT . History: Accepted by Giacomo Nannicini, Area Editor for Quantum Computing and Operations Research. Accepted for Special Issue. Funding: This work was supported by the U.S. Department of Energy’s Advanced Research Projects Agency–Energy [Grant DE-SC0020273], the Alfred P. Sloan Foundation, the Simons Foundation [Simons Investigator Award 825053], the Simons Quantum Postdoctoral Fellowship, the National Science Foundation [Grants CCF-1816695, CCF-1942837, and ECCS-2045978], the Unitary Fund, and the Air Force Office of Scientific Research [Grant FA95502110051]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2024.0587 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2024.0587 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
A TEORIA DA DIALOGICIDADE EM MARTIN BUBER E PAULO FREIRE: APROXIMAÇÕES E DIVERGÊNCIAS CONCEITUAIS
Authors: Oliveira Waldma Maíra Menezes de , Oliveira Ivanilde Apoluceno de , Matos Lyandra Lareza da Silva 
Published: November 2024

ResumoEste artigo tem como eixo principal a análise sobre a dialogicidade no pensamento educacional de Paulo Freire e Martin Buber, isto é, versará sobre a categoria diálogo como elemento central. A pesquisa objetiva realizar um estudo comparativo sobre as teorias da dialogicidade dos dois pensadores. Trata-se de uma pesquisa bibliográfica, cujos procedimentos metodológicos são o levantamento bibliográfico e a sistematização e análise dos dados, na qual se utilizou a técnica da Análise de Conteúdos. O uso da comparação, enquanto perspectiva de análise possibilita realizar aproximações e discordâncias presentes na base epistêmica Freireana e Buberiana. Os referenciais mais representativos foram: Freire (1979, 1980a, 1980b, 1996, 1997, 2007 e 2017); Buber (2012); Querette (2007); Zuben (2012) e Schneider (1998). A concepção freireana de educação é reconhecidamente uma referência nas práticas educativas no contexto brasileiro, por outro lado o pensamento educacional Buberiano não é tão disseminado, apesar de sua grande contribuição para a educação. Identificamos pontos de aproximações e de afastamentos entre esses dois autores em termos da teoria da dialogicidade em suas dimensões existencial, ético-política e educacional. Todavia, não se trata de realizar uma problematização sobre qual concepção é melhor visibilizada, pois além de questões de construções teóricas particulares, os autores vivenciaram épocas e contextos diferentes. Assim o mais interessante é entender a contribuição que ambos trazem para o campo educacional, consequentemente para a vida humana. Palavras-Chave: Diálogo; Educação; Paulo Freire; Martin Buber
Risk factors for a failed first attempt at pediatric subclavian central venous catheters and the role of single-attempt placement in reducing catheter-related morbidity: a prospective observational study
Authors: Jarraya Anouar , Kammoun Manel , Bouchaira Hasna , Ketata Hind , Ammar Saloua , Mhiri Riadh 
Published: November 2024

Introduction: The aim of this observational study was to investigate the risk factors of a failed first attempt at pediatric central venous catheter (CVC) placement and its impact on CVC-related morbidity. Materials and Methods: In this prospective observational study, we included 3-month-to 5-year-old children proposed for infraclavicular subclavian vein catheterization consecutively sing the anatomic landmark technique. Patients were divided into two groups: group 1 included single-attempt catheter placements, and Group 2 included failed first attempts at catheter placement. The management protocol was standardized for all patients. After comparing the two groups, univariable logistic regression was used to investigate the risk factors for a failed first attempt and to show the interest of the single-attempt catheter placement. Results: Among 150 pediatric CVC placements, the incidence of failed first attempts was 41.3% and its main risk factors were children with comorbidities (OR=3.11; 95%CI: 1.17–8.21), hematology and oncology patients (OR=5.6; 95%CI: 2.75–11.38), children with aplastic anemia (OR=3.05; 95%CI:1.388–6.705), and anesthesia sedation with I-Gel airway ventilation (OR=9.21; 95%CI: 1.080–78.5). On the other hand, a single-attempt catheter placement was a protective factor against catheter-related complications with OR=0.258 [0.12–0.55]. Conclusion: It seems that a single-attempt CVC placement may reduce the incidence of complications. The knowledge of the main risk factors of failed first attempts is mandatory for taking necessary precautions.
The situatedness of dilemmas in boundary spaces: uncovering paradoxical conditions for increasing effectiveness through transdisciplinary research approaches
Authors: Palmer Henrietta , Polk Merritt , Raviola Elena 
Published: November 2024

Organising ‘boundary spaces’ has become a practice for tackling wicked issues in societal planning. Such spaces bring together diverse actors to intentionally staged problem formulation and management processes. However, despite clear goals, boundary spaces face challenges. Moreover, the processes often generate dilemmas and paradoxes that participating actors are incapable of managing within the boundary space itself. In some situations, such tensions can amplify challenges or prevent results from impacting participating organisations. Using a transdisciplinary (TD) research approach, the aim of this article is to develop a better understanding of the different dilemmas and paradoxes that surround or arise within boundary spaces and thereby contribute to increasing their effectiveness in tackling the issues they were created to address.
This article originates from a TD research project that investigated four different boundary spaces of societal planning and research in Sweden. The project employed an iterative TD process that combined theoretical contributions from planning- and organisation studies with practical experiences from societal planning, and facilitation. The position of boundary spaces as being ‘between’ actors – ‘between’ in terms of representation and decision making – calls for further attention to the situatedness of dilemmas and paradoxes in space and time. Our approach resulted in an analytic framework where the dilemmas and paradoxes of boundary spaces were categorised as contextual, relational, process- or transformation-related. The results point at the relations between what we see as three interrelated tensions that ground the existence and functioning of boundary spaces: the mismatch dilemma, the commoning dilemma and the collaboration paradox.