bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seven-Doppler Radar and In Situ Analysis of the 25–26 June 2015 Kansas MCS during PECAN
Authors: Miller Rachel L. , Ziegler Conrad L. , Biggerstaff Michael I. 
Published: October 2019

AbstractThis case study analyzes a nocturnal mesoscale convective system (MCS) that was observed on 25–26 June 2015 in northeastern Kansas during the Plains Elevated Convection At Night (PECAN) project. Over the course of the observational period, a broken line of elevated nocturnal convective cells initiated around 0230 UTC on the cool side of a stationary front and subsequently merged to form a quasi-linear MCS that later developed strong, surface-based outflow and a trailing stratiform region. This study combines radar observations with mobile and fixed mesonet and sounding data taken during PECAN to analyze the kinematics and thermodynamics of the MCS from 0300 to 0630 UTC. This study is unique in that 38 consecutive multi-Doppler wind analyses are examined over the 3.5 h observation period, facilitating a long-duration analysis of the kinematic evolution of the nocturnal MCS. Radar analyses reveal that the initial convective cells and linear MCS are elevated and sustained by an elevated residual layer formed via weak ascent over the stationary front. During upscale growth, individual convective cells develop storm-scale cold pools due to pockets of descending rear-to-front flow that are measured by mobile mesonets. By 0500 UTC, kinematic analysis and mesonet observations show that the MCS has a surface-based cold pool and that convective line updrafts are ingesting parcels from below the stable layer. In this environment, the elevated system has become surface based since the cold pool lifting is sufficient for surface-based parcels to overcome the CIN associated with the frontal stable layer.
Interventions reducing sedentary behaviour of adults: An update of evidence
Authors: Sutherland Casey A , Kynn Mary , Cole Rachel L , Gray Marion A 
Published: October 2019

Objectives: This review updates evidence of previous reviews on interventions that target reducing sedentary behaviour among 18- to 69-year-old working aged adults. Methods: A literature search of PubMed, Informit, Scopus, EBSCO, Web of Science and ProQuest. Quality was assessed for individual articles using McMaster University Guidelines. Descriptive analysis was used to summarise findings across studies. Results: Fifteen studies were identified with critical appraisal scores ranging from 10 to 14 (of a possible 15), with a mean score of 11.7 indicating overall moderate quality. The majority of interventions were implemented in the workplace. Others were based in the neighbourhood and education institution settings. Just over half of the studies ( n = 9) reported a significant decrease in sedentary behaviour, including in total sedentary behaviour and sitting time, work sitting time and leisure sitting time. Overall sitting time decreases ranged from 8 to 122 minutes per day across all settings. Conclusion: There is some emerging evidence that sedentary behaviour interventions have the potential to reduce sedentary behaviour of working aged adults. However, given the paucity of literature, the effectiveness of such interventions is currently inconclusive. Further high-quality research across different settings is needed using validated standardised measures of sedentary behaviour.
T2 mapping of the extraocular muscles in healthy volunteers: preliminary research on scan–rescan and observer–observer reproducibility
Authors: Qian Wen , Chen Wei , Xu Xiao-Quan , Wu Fei-Yun 
Published: October 2019

Background T2-mapping technique and derived T2 relaxation time allows quantitative assessment of extraocular muscles; however, the reproducibility of T2 mapping-derived parameters was seldom studied till now. Purpose To evaluate the scan–rescan and observer–observer reproducibility of T2 relaxation time measurements of extraocular muscles in young healthy volunteers. Material and Methods Fourteen volunteers underwent T2-mapping examinations of the extraocular muscles three times within one month on a 3.0-T MR system. Scan–rescan and observer–observer reproducibility of T2 relaxation time measurements of the extraocular muscles were assessed using intraclass correlation coefficient and coefficient of variation. Results Both scan–rescan (short-term and long-term) and observer–observer could achieve good to excellent reproducibility, while better short-term than long-term scan–rescan reproducibility was obtained. The coefficient of variation of the T2 relaxation time of each extraocular muscles during both scan–rescan and observer–observer reproducibility assessment were <6%. Conclusion T2 relaxation time measurement of the extraocular muscles is proven to be highly reproducible at 3.0 T. T2 mapping may be a potential imaging technique in the diagnosis and follow-up of orbital diseases involved extraocular muscles in further studies.
The Effect of Preexisting and Shoulder-Specific Depression and Anxiety on Patient-Reported Outcomes After Arthroscopic Rotator Cuff Repair
Authors: Lau Brian C. , Scribani Melissa , Wittstein Jocelyn 
Published: October 2019

Background: Few studies have considered the potential effect of depression or anxiety on outcomes after rotator cuff repair. Purpose: To evaluate the effect of a preexisting diagnosis of depression or anxiety, as well as the feeling of depression and anxiety directly related to the shoulder, on the American Shoulder and Elbow Surgeons (ASES) score. Study Design: Cohort study; Level of evidence, 3. Methods: This study is a retrospective review of prospectively collected data on patients who underwent arthroscopic rotator cuff repair and were evaluated by the ASES score preoperatively and at a minimum 12 months postoperatively as part of the senior author’s shoulder registry. Preexisting diagnoses of depression and/or anxiety were recorded, and questions from the Western Ontario Rotator Cuff Index directed at feelings of depression or anxiety related to the shoulder were also evaluated. The Wilcoxon rank sum test was used to compare ASES scores between patients with and without anxiety and/or depression. Spearman correlation was used to correlate questions on depression and anxiety with ASES scores. Results: A total of 187 patients (63 females, 124 males; mean age, 58.6 years, SD, 8.7 years) undergoing arthroscopic rotator cuff repair were evaluated with a mean follow-up of 47.5 months (SD, 17.4 months; range, 12-77 months). Fifty-three patients (mean age, 60 years; SD, 8.6 years) had preexisting diagnoses of depression and/or anxiety and 134 patients (mean age, 58.1 years; SD, 8.7 years) did not. Patients with depression and/or anxiety had significantly lower preoperative and postoperative ASES scores (60.7 vs 67.8, P = .014; and 74.6 vs 87.1, P = .008, respectively). The change in ASES scores from preoperative to postoperative, however, was not significantly different (18.0 vs 14.9). A higher score of depression or anxiety related to the shoulder had a negative correlation with the preoperative ( r = −0.76, P < .0001; and r = −0.732, P < .0001, respectively) and postoperative ( r = −0.31, P = .0001; and r = −0.31, P = .0003, respectively) ASES scores, but a positive correlation ( r = 0.50, P < .0001; and r = 0.43, P < .0001, respectively) with the change in ASES scores. Conclusion: Patients with a history of depression and/or anxiety have lower outcome scores preoperatively and postoperatively; however, they should expect the same amount of relief from arthroscopic rotator cuff repair as those without a history of depression or anxiety. Stronger feelings of depression or anxiety directly related to the shoulder correlated with lower preoperative and postoperative outcome scores, but a greater amount of improvement from surgery. The results from this study suggest that a preexisting diagnosis of depression or anxiety, as well as feelings of depression or anxiety directly related to the shoulder, should be considered during the management of patients with rotator cuff tears.
Risk Factors for Intolerance of Inpatient Sacubitril/Valsartan Initiation
Authors: Akerman Caitlin C. , Beavers Janna C. 
Published: October 2019

Background: Sacubitril/valsartan has been shown to improve outcomes in patients with heart failure with reduced ejection fraction (HFrEF). However, initiation of sacubitril/valsartan has primarily been studied in stable, ambulatory patients with HFrEF. Objective: The objective of this study was to determine risk factors for intolerance to inpatient sacubitril/valsartan initiation. Methods: This was a retrospective, single-center study from August 1, 2015 through April 30, 2018. Patients were at least 18 years old and were newly initiated on sacubitril/valsartan during their hospitalization. Results: A total of 143 patients met inclusion criteria. Of these patients, 20.3% (n = 29) were intolerant to inpatient initiation of sacubitril/valsartan. The primary reason for intolerance was hypotension (n = 19, 65.5%). Patients with newly diagnosed heart failure were more likely to tolerate the initiation of sacubitril/valsartan (32.5% vs 10.3%; P = 0.03). No differences between groups were identified among other potential predictors for intolerance to sacubitril/valsartan, including systolic blood pressure, acutely decompensated heart failure, or serum creatinine. The most common adverse event was hypotension, which occurred in 26.6% (n = 38) of all patients. Conclusion: The majority of inpatients tolerated sacubitril/valsartan initiation. Larger, prospective, randomized controlled trials would be helpful in further determining ideal candidates for inpatient sacubitril/valsartan initiation.
Norcepharadione B attenuates H2O2-induced neuronal injury by upregulating cellular antioxidants and inhibiting volume-sensitive Cl− channel
Authors: Jia Xin , Liu Yan , Li Xing , Huo Cong , Li Dongtao , Xu Rong , Hou Liming , Wang Xiaoming 
Published: October 2019

Oxidative stress acts as an essential culprit factor in the development of stroke and Alzheimer’s disease. Norcepharadione B possesses various pharmacologic features as an extract obtained from Houttuynia cordata. Nevertheless, the anti-apoptotic and neuroprotective characteristics of norcepharadione B remain unclear. In this study, the neuronal protection effect provided by norcepharadione B against injury caused by hydrogen peroxide (H2O2) in HT22 cell as well as the fundamental mechanism was systematically explored. The neurotoxicity assays of hippocampal cells, which were co-cultured with H2O2, showed that norcepharadione B had the ability to insulate the toxicity induced by H2O2 with significant reduced cell apoptosis. Besides, norcepharadione B potentiated the activity of superoxide dismutase (SOD), increased the level of glutathione (GSH), and decreased malondialdehyde content. The H2O2-induced apoptotic protein Bax was suppressed, and the anti-apoptotic protein Bcl-2 was boosted by norcepharadione B. Norcepharadione B promoted Akt phosphorylation and further upregulated heme oxygenase (HO-1) in cells exposed to oxidative stress. However, the inductive effect of HO-1 by norcepharadione B was shut off via the PI3K/Akt inhibitor LY294002. Furthermore, 2-h incubation with H2O2 substantially increased cell volume in HT22 cells, while norcepharadione B effectively alleviated such effect by interrupting the activation of VSOR Cl− channel. Collectively, our data revealed protective properties of norcepharadione B in resisting oxidative stress induced by H2O2 through elevation of HO-1 in the dependence of PI3K/Akt and in inhibiting H2O2-induced cell swelling by VSOR Cl− channel obstruction in HT22 cells. Impact statement Norcepharadione B is an aporphine alkaloid compound extracted from Chinese herb Houttuynia cordata. It was well known for its anti-inflammatory, anti-cancer, and anti-platelet aggregation outcomes. Our study demonstrated that Norcepharadione B protected hippocampal neurons against oxidative stress and the resultant cell apoptosis upon H2O2 exposure. Meanwhile, Norcepharadione B also substantially reduced cell swelling induced by H2O2 via inhibiting VSOR Cl− channel in neurons. These findings uncovered the potential mechanisms of Norcepharadione B in protecting neuron apoptosis under oxidative stress and propose that Norcepharadione B may serve as a favorable herb medicine for restoring neuronal injury in the pathogenesis of stroke together with other neurodegenerative diseases.
Correlation Between the Immediate Remnant Stump Length and Vein Diameter After Cyanoacrylate Closure Using the VenaSeal System During Treatment of an Incompetent Great Saphenous Vein
Authors: Park Insoo , Kim Daehwan 
Published: October 2019

Objectives: Cyanoacrylate glue is injected for incompetent great saphenous vein (GSV) treatment 5 cm distal to the saphenofemoral junction (SFJ). Although a few reports have investigated the postprocedural remnant stump length, none have focused on the factors affecting glue extension length and the consequent remnant stump length. Methods: Seventy-nine patients undergoing cyanoacrylate closure using the VenaSeal system at our clinic between August 2018 and November 2018 were investigated. The GSV diameter was measured just before treatment in the supine position 3 cm distal to the SFJ. Cyanoacrylate glue was injected 5 cm distal to the SFJ. Results: The mean glue extension length was 1.13 ± 1.12 cm. The GSV diameter and glue extension length exhibited a significant inversely proportional relationship ( P < .001). More specifically, patients with a GSV diameter ≥0.7 cm had a longer remnant stump length than those with a smaller GSV diameter ( P < .001). Conclusions: An increased GSV diameter is likely associated with a decreased glue extension length and, consequently, a longer remnant stump.
The association between volition and participation in adults with acquired disabilities: A scoping review
Authors: Harel-Katz Hagit , Carmeli Eli 
Published: October 2019

Background/objective Physical, cognitive and psychological factors such as self-efficacy and motivation affect participation in populations with acquired disabilities. Volition is defined as a person's motivation for participating in occupation. The concept of ‘volition’ expands similar concepts and theories, which focus mostly on cognitive processes that influence motivation. Although volition seems to affect participation, the association between these two concepts has not been examined in populations with acquired disabilities. This scoping review explored this association. Methods The literature review used a structured five-stage framework, according to predefined inclusion and exclusion criteria. Seven electronic databases (CINAHL, PsycINFO, PubMed, Web of Science, SCOPUS, The Cochrane Library-Wiley, OTseeker) and Google Scholar were searched for relevant articles, published in English from January 2001 to May 2018. Results A total of 18 articles, relating to populations with various diagnoses were included. Two directly examined volition and participation and showed a positive association between them. Other articles discussed the effect of participants’ chronic condition on their volition and participation, the effect of volition on participation, or the effect on participation of an intervention addressing volition. Conclusions An acquired disability affects both volition and participation, and volition seems to affect participation among people with acquired disabilities. Few articles showed positive effects of interventions that addressed clients' volition, on participation. Further research should include additional health conditions and types of literature, to better understand the association between these concepts. This understanding will contribute to the development of occupational therapy interventions that emphasise volition, in order to improve participation outcomes.
Patient satisfaction after treatment of distal radial fractures in older adults
Authors: Chung Kevin C. , Sasor Sarah E. , Speth Kelly A. , Wang Lu , Shauver Melissa J. ,   For the WRIST Group
Published: October 2019

The Wrist and Radius Injury Surgical Trial (WRIST) collaboration is the largest clinical trial ever conducted in hand surgery. We applied data from this study to examine the relationship between functional outcomes and patient satisfaction after treatment of distal radial fractures. Patients aged 60 years and older with isolated distal radial fractures were enrolled at 24 health systems. Grip strength and the arc of wrist motion were measured after treatment. The Michigan Hand Outcomes Questionnaire was used to measure patient satisfaction. Receiver operating characteristic curves were created using patient satisfaction as the reference standard and each functional measure as a predictor. At 12 months after treatment, mean grip strength was 82% of normal and mean arc of motion was 88% of normal. The optimal cut-off points to distinguish satisfaction from dissatisfaction occurred when patients recovered 59% of hand strength and 79% of wrist motion. Continuing therapy to increase functional gains beyond this point unnecessarily utilizes healthcare resources without additional patient-reported gains. Level of evidence: IV
The Modified Subcapital Metatarsal Osteotomy in the Treatment of Hallux Valgus Recurrence
Authors: Scala Andrea , Cipolla Massimo , Giannini Silvana , Oliva Giulio 
Published: October 2019

The purpose of the present study is to illustrate the use of a modified subcapital metatarsal osteotomy (MSMO) in the treatment of hallux valgus (HV) recurrence. The article reports the clinical and radiological outcomes of a cohort of 52 consecutive patients presenting with recurrent HV, treated with MSMO. A total of 52 patients (54 feet) underwent operations between May 2010 and November 2015. The mean time of follow-up was 2.5 years (range 5.5-1.0 years), and the mean age was 49 years (range 22-76 years). The patient cohort comprised 46 female and 6 male patients. The results of this research show that MSMO is a reliable technique for the correction of HV recurrence. The postoperative radiographic assessments show a statistically significant postoperative improvement of the HV angle (P < .05) and the intermetatarsal angle (P < .05). The postoperative position of the tibial sesamoid was significantly improved (P < .1). The distal metatarsal articular angle was improved (P < .001), though assessment may be affected by the previous operations performed on the first metatarsophalangeal joint. The statistical analysis shows that the postoperative American Orthopaedic Foot and Ankle Society Hallux Metatarsophalangeal-Interphalangeal Scale parameters were significantly improved (P < 0.001). Results of this study indicate that the minimally invasive MSMO is effective in restoring anatomical alignment and improving patient outcomes in recurrent cases of HV. Levels of Evidence: Level III: Case-control study
Comorbid chronic pain and post-traumatic stress disorder in UK veterans: a lot of theory but not enough evidence
Authors: Morgan Louise , Aldington Dominic 
Published: October 2019

Introduction: Chronic pain and post-traumatic stress disorder (PTSD) are strongly correlated in military veteran populations. The aim of this article is to review what is known about the comorbidity of the two conditions. Methods: A literature search was carried out to establish evidence for current explanatory models of why the two conditions frequently co-occur, the most appropriate treatments and current UK service provision for veterans and to identify gaps in research. Results: Chronic pain and PTSD share a number of features, yet the mechanisms behind their comorbidity are not well understood, and while each condition alone has extensive literature, there is limited evidence to support specific care and treatment for the two conditions simultaneously. In addition, there is currently no UK data for veterans with comorbid chronic pain and PTSD so it is not possible to gauge the numbers affected or to predict the numbers who will be affected in the future, and there appear to be no co-located services within the United Kingdom for the management of the two conditions simultaneously in this population. Conclusion: This review highlights a paucity of evidence in all areas of comorbid chronic pain and PTSD. Further work needs to consider fully the nature of the event that led to the development of the two conditions and examine further the possible mechanisms involved, and clinics need to establish routine and systematic evaluations of how any interventions work in practice.
CAGEfightR: analysis of 5′-end data using R/Bioconductor
Authors: Thodberg Malte , Thieffry Axel , Vitting-Seerup Kristoffer , Andersson Robin , Sandelin Albin 
Published: October 2019

Abstract

Background
5′-end sequencing assays, and Cap Analysis of Gene Expression (CAGE) in particular, have been instrumental in studying transcriptional regulation. 5′-end methods provide genome-wide maps of transcription start sites (TSSs) with base pair resolution. Because active enhancers often feature bidirectional TSSs, such data can also be used to predict enhancer candidates. The current availability of mature and comprehensive computational tools for the analysis of 5′-end data is limited, preventing efficient analysis of new and existing 5′-end data.

Results
We present CAGEfightR, a framework for analysis of CAGE and other 5′-end data implemented as an R/Bioconductor-package. CAGEfightR can import data from BigWig files and allows for fast and memory efficient prediction and analysis of TSSs and enhancers. Downstream analyses include quantification, normalization, annotation with transcript and gene models, TSS shape statistics, linking TSSs to enhancers via co-expression, identification of enhancer clusters, and genome-browser style visualization. While built to analyze CAGE data, we demonstrate the utility of CAGEfightR in analyzing nascent RNA 5′-data (PRO-Cap). CAGEfightR is implemented using standard Bioconductor classes, making it easy to learn, use and combine with other Bioconductor packages, for example popular differential expression tools such as limma, DESeq2 and edgeR.

Conclusions
CAGEfightR provides a single, scalable and easy-to-use framework for comprehensive downstream analysis of 5′-end data. CAGEfightR is designed to be interoperable with other Bioconductor packages, thereby unlocking hundreds of mature transcriptomic analysis tools for 5′-end data. CAGEfightR is freely available via Bioconductor:
bioconductor.org/packages/CAGEfightR
.
Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats
Authors: Sharifi Fatemeh , Reisi Parham , Malek Maryam 
Published: October 2019

AbstractBackgroundNeurological complications may occur in patients with acute or chronic renal failure; however, in cases of acute renal failure, the signs and symptoms are usually more pronounced, and progressed rapidly. Oxidative stress and nitric oxide in the hippocampus, following kidney injury may be involved in cognitive impairment in patients with uremia. Although many women continue taking hormone therapy for menopausal symptom relief, but there are also some controversies about the efficacy of exogenous sex hormones, especially estrogen therapy alone, in postmenopausal women with kidney injury. Herein, to the best of our knowledge for the first time, spatial memory and synaptic plasticity at the CA1 synapse of a uremic ovariectomized rat model of menopause was characterized by estradiol replacement alone.ResultsWhile estradiol replacement in ovariectomized rats without uremia, promotes synaptic plasticity, it has an impairing effect on spatial memory through hippocampal oxidative stress under uremic conditions, with no change on synaptic plasticity. It seems that exogenous estradiol potentiated the deleterious effect of acute kidney injury (AKI) with increasing hippocampal oxidative stress.ConclusionsAlthough, estrogen may have some positive effects on cognitive function in healthy subjects, but its efficacy in menopause subjects under uremic states such as renal transplantation, needs to be further investigated in terms of dosage and duration.