bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing Patient Health Questionnaire Depression Screening in Inflammatory Arthritis Clinic: Insights From a Quality Improvement Project at a Tertiary Rheumatology Center
Authors: Yu Jeong Min , Goodman Susan , Rakowicz Ann Marie , Bugante Julius , Lee Jennifer Inhae 
Published: October 2024

ObjectiveThis quality improvement project evaluates the feasibility and sustainability of adopting the Patient Health Questionnaire (PHQ) depression screening tool into routine clinical care at a rheumatology fellows’ inflammatory arthritis (IA) clinic at a large tertiary center. The aim was to achieve 50% compliance in documentation of PHQ after five months.MethodsProviders received a 30‐minute education on the importance of depression screening in patients with IA. A week after the education, two‐step depression screening with the PHQ‐2 followed by the PHQ‐9 was implemented. Nurses performed PHQ‐2 at each IA clinic visit verbally and documented the results while rooming patients using an electronic health record (EHR) dotphrase. Patients completed paper forms of the PHQ‐9 only if the PHQ‐2 score was positive for depression. Fellows then reviewed the PHQ‐9 during the clinic visit and documented it using a separate EHR dotphrase. We tracked both PHQ‐2 and PHQ‐9 documentation rates as the key outcome measures.ResultsBefore to the intervention, depression documentation rate was only 2%. After initial poor participation, nurses achieved the aim after repeated reminders and ongoing education by the senior nurse. Fellows failed to achieve the aim despite repeated reminders and education. Lack of time during clinic visit was found to be the biggest challenge.ConclusionSustained adoption of the PHQ was difficult to achieve. Additional support at the health systems level that prioritizes depression screening may need to take place. Additional research demonstrating improved IA outcomes in screened patients may also be helpful to gain more buy‐in from providers.
Self‐Oxygenated Biomimetic Nanozyme for Tumor Catalytic Immunotherapy
Authors: Zhang Baohua , Yuan Ye , Xin Qi , Wang Shuyu , Feng Yiming , Yan Xiyun , Fan Tianli , Jiang Bing , Yue Yale 
Published: October 2024

AbstractThe treatment of solid tumors remains a significant challenge due to the complex, immunosuppressive tumor microenvironment (TME). This manuscript introduces the self‐oxygenated biomimetic nanozyme system, SS‐MSN@Au‐BOM, which innovatively combines catalytic therapy with immunotherapy to modulate the TME for enhanced therapeutic efficacy. Employing mesoporous silicon nanoparticles doped with disulfide bonds, the system integrates gold nanozymes that exhibit glucose oxidase (GOx)‐like and peroxidase (POD)‐like activities, along with a catalase (CAT) function derived from bacterial outer membrane (BOM) coatings. SS‐MSN@Au‐BOM significantly disrupted tumor growth by catalyzing endogenous hydrogen peroxide to generate cytotoxic ROS and essential oxygen, enhancing intratumoral ROS levels while alleviating hypoxia. This catalytic action facilitates immunogenic cell death, enhances dendritic cell maturation, and T‐cell activation. Notably, the system shows excellent biocompatibility, effective tumor targeting, and prolonged systemic circulation. SS‐MSN@Au‐BOM offers a dual‐functional approach that effectively disrupts the TME and promotes robust antitumor immunity. This study paves the way for further clinical investigation and the development of enzyme‐based therapeutics, potentially transforming the landscape of cancer treatment.
A Fluorescent Polyvinyl Alcohol Film with Efficient Photodynamic Antimicrobial Performance Enabled by Berberine/Phytic Acid Salt for Food Preservation
Authors: Ning Yuping , Yang Wen , Liu Shuaimin , Xu Jin , Cheng Xiling , Xu Shiyu , Li Jian , Wang Lijuan 
Published: October 2024

AbstractFood packaging that impedes microbial growth and can be safely used is critical to attenuate food spoilage. Herein, a green berberine/phytate salt (BPA) is successfully synthesized and aggregated in polyvinyl alcohol (PVA) film to impart fluorescent and photodynamic antimicrobial properties. Compared to berberine hydrochloride (BHL), BPA exhibited stronger fluorescence because intramolecular motions and intermolecular π–π accumulation of BHL are restricted by phytic acid (PA). Molecular dynamics simulation indicate that aggregation of BHL and PA formed through electrostatic interactions in the PVA matrix due to the change of the binding energy during the drying process. With increasing BPA content, the films exhibited increased ultraviolet, water vapor, and oxygen barriers and fluorescent properties, but reduced tensile strength and elongation at break. After radiated, PVA‐BPA9 film showed the highest antimicrobial rates against Staphylococcus aureus, Escherichia coli, P. citrinum, and Aspergillus niger reached 100%, 100%, 86.14%, and 66.24%, respectively, due to the increased reactive oxygen species production. The total number of microbial colonies in cooked chicken and oranges packaged by PVA‐BPA9 film with irradiation ARE 87.54% and 29.21% of those by PVA film. The findings indicate a new and feasible strategy to obtain a green photodynamic‐mediated film for safe and effective food packaging.
Controlled Growth of 2D‐3D Perovskite Lateral Heterostructures for Wavelength‐Tunable Light Communication
Authors: Fan Xueshuo , Hong Enliu , Wang Peixi , Fang Xiaosheng 
Published: October 2024

AbstractLateral heterostructures based on halide perovskites exhibit great potential in the advancement of next‐generation optoelectronic devices. Among them, mixed dimensional perovskite heterostructures, particularly 2D‐3D ones, offer promising opportunities for semiconductor integration and device miniaturization by combining the advantages of 2D and 3D perovskites. However, the controllable and rapid growth of 2D‐3D halide perovskite lateral heterostructures has not yet been achieved. This study presents an efficient strategy that integrates one‐pot method and space‐confined process to enable liquid‐phase lateral growth of a series of 2D Ruddlesden‐Popper (RP) perovskites on the sides of 3D perovskites. The photodetectors (PDs) based on (BA)2MAn‐1PbnBr3n+1‐MAPbBr3 (n = 1, 2, 3) lateral heterostructures demonstrate outstanding optoelectronic performance, featuring an on/off ratio of up to 1.4 × 104, a high responsivity of 4.4 A W−1 and a detectivity of 3.9 × 1013 Jones at 425 nm, 3 V bias. In addition, by combining the tunable dual‐band photoresponse characteristic with the dual‐beam irradiation modes, a wavelength‐tunable light communication system based on the lateral heterostructure PDs is realized. This work provides a convenient and reliable approach for the direct growth of mixed‐dimensional halide perovskite heterostructures, further demonstrating their potential in high‐performance detecting and dual‐band sensing fields.
Shape‐Programmable Lamellar Aerogel Enabling 3D Wireless Point‐of‐Care Electronics for Assistance in Pressure Injury Prevention
Authors: Huang Jinhui , Liu Hao , Chen Qiuyu , Xie Hui , Zhou Shaobing 
Published: October 2024

AbstractBedridden patients are at high‐pressure injuries risk, and timely turning or moving a bedridden patient is crucial to release localized pressure and reduce pressure injury risk. Pressure‐sensing electronics can collect real‐time pressure signals reflecting the movement of a patient and help carers evaluate pressure injury risk early and intervene timely. However, most pressure‐sensing electronics cannot be seamlessly mounted on the curved surface of the skin, resulting in signal instability and inaccuracy. Besides, detecting small pressures over a wide range is challenging. Herein, a lamellar shape‐memory conductive (LSMC) aerogel is developed to assemble 3D wireless point‐of‐care electronics for assisting pressure injury prevention. The lamellar structure makes the LSMC aerogel highly compressible, endowing the assembled electronics with high sensitivity and low detection limit. Moreover, the excellent shape‐memory effect allows the fabrication of 3D electronics on certain curved surfaces for adaptive wearing and provides sensitive and stable signals. Furthermore, a point‐of‐care monitoring system that integrates the LSMC aerogel‐based 3D electronics with wireless technology is developed. The system records real‐time pressure signals at certain locations (e.g., foot), which facilitates carers to analyze an individual's bedridden time and body movements, assess pressure injury risk, and intervene timely; this greatly benefits pressure injury prevention.
Tendon‐Driven Stiffness‐Tunable Soft Actuator via Thermoelectric‐based Bidirectional Temperature Control
Authors: Gao Yunlong , Lin Shikun , Liang Chuanwei , Qiu Siqi , Long Chengyun , Wang Yingjun , Li Yunquan , Zhang Yuan‐Fang 
Published: October 2024

AbstractSoft robots have excellent spatial adaptability and high flexibility, but they are limited by the low stiffness of their constituent materials when faced with high‐load tasks. In recent years, there have been many works on the development of stiffness‐tunable soft actuators by introducing variable stiffness materials into soft actuators, but the existing solutions usually suffer from the problems of slow response, complex structure, and the need of many auxiliary devices to support the completion of the stiffness tuning cycle. This paper proposes a tendon‐driven stiffness‐tunable soft actuator that addresses these issues. Benefiting from the bidirectional temperature control of thermoelectric modules and the excellent in‐plane thermal conductivity of graphene, the actuator is capable of achieving the heating and cooling process by transferring the heat flow through the graphene structure into and out of the shape‐memory polymer (SMP) layer of the tendon‐driven actuator. This enables stiffness tuning via a single device, reducing the dependence on complex external cooling systems. The use of tendon‐driven actuators further eliminates the complex bellow structure of conventional pneumatic actuators and dramatically reduces the size and manufacturing difficulty of individual actuators. Finally, the high load capacity and shape adaptability of the actuator are demonstrated by a gripper equipped with three actuators, which successfully grips objects of various shapes and weights, ranging from less than 10 g to up to 1.6 kg.
Adsorption of Imidazolium‐Based Ionic Liquid On Pt(111) Surface Studied Using Density Functional Theory
Authors: Sarkar Arka Prava , Reddy Sandeep K. 
Published: October 2024

AbstractThe strength and nature of adsorption of imidazolium‐based tetraflouroborate ionic liquid (IL) on platinum surface has been investigated via first principle‐based density functional theory method. Adsorption of both IL cation and IL ion‐pair as a function of increasing alkyl chain length is taken into consideration. Three different orientations of ionic liquid cations are found to be stable with higher adsorption energy noticed for the alkyl chain parallel to the platinum surface. The anions are found to stabilize the IL cation orientation where the alkyl chain is oriented perpendicular the platinum surface. These results are further corroborated by the charge transfer analysis and electron density difference maps. The significant charge transfer between the ionic liquid pair and the surface indicates electrochemical applications for systems involving electrolytes and metal surface, where electrostatic interactions play a major role. The results of this investigation can be helpful for further analysis of electrode–electrolyte systems as well as the development of force field parameters for these systems.
Insights into Tiny High‐Entropy Doping Promising Efficient Sodium Storage of Na3V2(PO4)2O2F toward Sodium‐Ion Batteries
Authors: Su Guoshuai , Wang Yongjia , Mu Jiawei , Ren Yongfeng , Yue Peng , Ji Weixiao , Liang Longwei , Hou Linrui , Chen Meng , Yuan Changzhou 
Published: October 2024

AbstractBoth high operation voltage and theoretical capacity promise polyanion‐type fluorophosphate Na3V2(PO4)2O2F as a competitive cathode toward high‐energy‐density sodium‐ion batteries (SIBs). However, the intrinsic low kinetic characteristics seriously influence its high‐power property and service life. To well address this, a creative tiny high‐entropy (HE) doping methodology is purposefully developed to fabricate nanoscale Na3V1.94(Cr, Mn, Co, Ni, Cu)0.06(PO4)3O2F (NVPOF‐HE) as the advanced cathode materials for SIBs. The grain refinement effect induced by collaborative regulations from polyvinyl pyrrolidone and tiny HE heteroatomic doping is reasonably proposed for nanosizing particle dimension of NVPOF‐HE. Systematic experiments and theoretical calculations authenticate that the HE doping efficiently promotes the electronic/ionic transport and high‐voltage capacity contribution, and weakens the lattice expansion over Na+‐(de)intercalation processes. Thanks to the appealing virtues mentioned here, the nano NVPOF‐HE, compared to single‐ion/dual‐ion/triple‐ion doped cases, achieves even better Na+‐storage performance in terms of both high‐rate capacities and long‐term cycling stability. Furthermore, the NVPOF‐HE assembled full SIBs deliver a high materials‐level energy density of 463 Wh kg−1 and electrochemical stability of ≈93.8% capacity retention after 1000 cycles at 5 C rate. More essentially, the fundamental insights gained here provide a significant scientific and technological advancement in high‐performance and durable polyanionic cathodes toward next‐generation SIBs.
Cost‐Effectiveness of Endovascular Thrombectomy in Patients with Large Ischemic Stroke
Authors: Gao Lan , Churilov Leonid , Johns Hannah , Pujara Deep , Hassan Ameer E. , Abraham Michael , Ortega‐Gutierrez Santiago , Hussain Muhammad Shazam , Chen Michael , Blackburn Spiros , Sitton Clark W. , Pinckaers Florentina M. E. , van Zwam Wim H. , Tsivgoulis Georgios , Hill Michael D. , Grotta James C. , Kasner Scott , Ribo Marc , Campbell Bruce C , Sarraj Amrou ,   For SELECT2 investigators
Published: October 2024

ObjectivesWhereas highly cost‐effective and cost‐saving for patients with small infarcts, whether endovascular thrombectomy (EVT) remains cost‐effective in patients with extensive ischemic injury is uncertain.MethodsWe conducted a model‐based cost‐effectiveness analysis from the United States, Australian, and Spanish societal perspectives, using a 7‐state Markov model, with each state defined by the modified Rankin Scale (mRS) score. Initial probabilities at 3 months were derived from the SELECT2 trial. All other model inputs, including transition probabilities, health care and non‐health care costs, and utility weights, were sourced from published literature and government websites. Our analysis included extensive sensitivity and subgroup analyses.ResultsEVT in patients with large ischemic stroke improved health outcomes and was associated with lower costs from a societal viewpoint. EVT was cost‐effective with a mean between‐group difference of 1.24 quality‐adjusted life years (QALYs), and a cost‐saving of $23,409 in the United States, $10,691 in Australia, and $30,036 in Spain, in addition to uncosted benefits in productivity for patients and carers. Subgroup analyses were directionally consistent with the overall population, notably with preserved cost‐effectiveness in older patients (≥ 70 years) and those with more severe strokes (National Institutes of Health Stroke Scale [NIHSS] ≥ 20). Sensitivity analyses were largely consistent with the base‐case results.InterpretationEVT demonstrated cost‐effectiveness in patients with large core across different settings in the United States, Australia, and Spain, including older patients and those with more severe strokes. These results further support adaptation of systems of care to accommodate the expansion of thrombectomy eligibility to patients with large cores and maximize EVT benefits. ANN NEUROL 2025;97:222–231
A Redox‐active Cyclometalated Platinum Ring Enables Synthetic Post‐processing of a [2]Rotaxane
Authors: Kandel Raksha , Soto Miguel A. , Medina Daniel , Patrick Brian O. , Lelj Francesco , MacLachlan Mark J. 
Published: October 2024

AbstractPost‐synthetic modification of mechanically interlocked molecules (MIMs) is an attractive avenue to add complexity to already intricate systems. This remains an important, challenging topic that is under‐developed. In this paper, we report the synthesis and characterization of a [2]rotaxane molecule featuring a ring appended to an emissive cyclometalated PtII unit. Modulation of the oxidation state at the metal center can transform the interlocked molecule into a new PtIV [2]rotaxane or a PtIII [3]rotaxane held together by an intermetallic Pt−Pt bond – a first of its kind. These molecules display distinct structural and photophysical properties, as well as shuttling dynamics. This approach for post‐synthetic modification could be used to construct more complex MIMs and inorganic supramolecular assemblies with redox properties.
Corannulene‐Based Quintuple [6]/[7]Helicenes: Well‐Preserved Bowl Core, Inhibited Bowl Inversion and Supramolecular Assembly with Fullerenes
Authors: Zhang Kaixin , Chen Zuo‐Chang , Wu Yin‐Fu , Tian Han‐Rui , Zhang Ling , Zhang Mei‐Lin , Deng Shun‐Liu , Zhang Qianyan , Xie Su‐Yuan , Zheng Lan‐Sun 
Published: October 2024

AbstractHerein, corannulene‐based quintuple [6]helicenes (Q[6]H‐1 and Q[6]H‐2) and [7]helicene (Q[7]H) were synthesized via penta‐fold Heck and Mallory reaction. Notably, Q[7]H represents the highest reported helicene based on corannulene. X‐ray crystallography reveals that Q[6]H‐2 adopts a propeller‐shaped conformation with a well‐preserved corannulene core, while Q[6]H‐1 and Q[7]H exhibit quasi‐propeller‐shaped conformations. Upon heating, conformer Q[6]H‐1 undergoes conversion to the thermodynamically more stable conformer Q[6]H‐2, whereas conformer Q[7]H remains unchanged due to larger steric congestion. Racemization of the enantiomer of Q[6]H‐1 and conformational conversion were observed simultaneously at elevated temperature, with DFT studies indicating a racemization barrier of 32.06 kcal ⋅ mol−1. In contrast, the racemization barrier for Q[6]H‐2 was calculated to be 45.46 kcal ⋅ mol−1, indicating exceptional chiral stability. Surprisingly, the bowl inversions of Q[6]H‐1 and Q[6]H‐2 conformers are somewhat inhibited by the helical blades, whereas this was not observed for other possible conformers of Q[6]H. These results first demonstrated that subtle conformational variations can lead to significant changes in chiral stability and bowl inversions of multiple helicenes. Due to the well‐preserved corannulene core, propeller‐shaped conformation and electron complementarity, Q[6]H‐2 can recognize fullerenes in both solution and solid state, which is a rare instance of co‐crystallization assembly between multiple helicenes and fullerenes.
Engineered Nanobodies Bind Bismuth, Indium and Gallium for Applications in Theranostics
Authors: Ghosh Pritha , Davies Lani J. , Nitsche Christoph 
Published: October 2024

AbstractTargeted theranostics heavily rely on metal isotopes conjugated to antibodies. Single‐domain antibodies, known as nanobodies, are much smaller in size without compromising specificity and affinity. The conventional way of conjugating metals to nanobodies involves non‐specific modification of amino acid residues with bifunctional chelating agents. We demonstrate that mutagenesis of a single residue in a nanobody creates a triple cysteine motif that selectively binds bismuth which is, for example, used in targeted alpha therapy. Two mutations create a quadruple cysteine mutant specific for gallium and indium used in positron emission tomography and single‐photon emission computed tomography, respectively. Labelling is quantitative within a few minutes. The metal nanobodies maintain structural integrity and stability over weeks, resist competition from endogenous metal binders like glutathione, and retain functionality.
Modification of ZIF‐8 Membranes for Gas Separation Using X‐ray Radiation
Authors: Lee Dennis T. , Ahmad Mueed , Corkery Peter , Anibal Boscoboinik J. , Fairbrother D. Howard , Tsapatsis Michael 
Published: October 2024

AbstractWe report an X‐ray radiation‐induced modification of the structure and gas permeation behavior of ZIF‐8 membranes. With 300 min irradiation time, CO2 permeance decreases by only 9 %, while N2 and CH4 permeances reduce by 75 and 65 %, respectively, leading to 3.7‐ and 2.6‐fold enhancements in ideal selectivity for CO2/N2 and CO2/CH4.
In Situ Catalyzed Growth of Carbon Nanotube with Asphalt Cladding as a Bicarbon Synergistic Framework of Silicon Anodes for Lithium‐ion Batteries
Authors: Liu Yiming , Duan Jianzheng , Chen Pengfei , Li Peihua , Zhang Wanggang , Li Xiaohong , Wang Jian 
Published: October 2024

AbstractSilicon, as the most promising advanced anode material for lithium‐ion batteries, faces challenges in large‐scale industrial production due to the significant volume expansion effect. In this investigation, Si/CNTs/C composite materials were effectively produced through high‐temperature carbonization utilizing asphalt, silicon, hexahydrate ferric chloride, and melamine as primary elements. The distinctive dual‐carbon framework of asphalt‐derived carbon and carbon nanotubes alleviates the volume expansion of silicon, thereby stabilizing the composite material's structure. Testing the electrochemical performance reveals that the Si/CNTs/C composite material exhibits a reversible specific capacity of 1187 mAh g−1 with a capacity retention rate of 92.6 % after 150 cycles at a current density of 0.2 A g−1. Even after 500 cycles at a current density of 1 A g−1, it sustains a specific capacity of 879.4 mAh g−1 with a capacity retention rate of 87.9 %, showcasing outstanding electrochemical performance.
Investigating the prognostic utility of GSTP1 promoter methylation in prostate cancer
Authors: Pidsley Ruth , Lam Dilys , Qu Wenjia , Stricker Phillip , Kench James G. , Horvath Lisa G. , Clark Susan J. 
Published: October 2024

AbstractObjectivesWe aim to determine the prognostic significance of glutathione S‐transferase Pi 1 DNA methylation (mGSTP1) in two independent prostate cancer cohorts with long‐term clinical follow‐up data.Subjects/Patients and MethodsWe first re‐examined a published, in‐house whole genome bisulphite sequencing (WGBS) prostate cancer dataset, derived from radical prostatectomy (RP) tissue (n = 15) with median follow‐up 19.5 years, to confirm and visualise the association between mGSTP1 and patient mortality. To validate prognostic significance, we used a quantitative methylation‐specific head‐loop (MS‐HL) assay to measure mGSTP1 levels in a larger, independent cohort (n = 186), and performed univariable and multivariable Cox survival analysis.ResultsRe‐analysis of WGBS data showed a significant increase in mGSTP1 in RP samples from patients with lethal versus non‐lethal disease. Subsequent analysis in the larger cohort using the MS‐HL assay confirmed that mGSTP1 was detectable in 97% of RP samples, validating the diagnostic potential of mGSTP1. Univariable Cox survival analysis revealed a significant association between mGSTP1 levels and biochemical recurrence and metastatic relapse free survival, with a near‐significant association with prostate cancer specific mortality. Notably, multivariable Cox models demonstrated that mGSTP1 did not add independent prognostic value beyond standard clinicopathological features.ConclusionOur study supports the importance of DNA methylation as a tissue‐based prostate tumour biomarker. GSTP1 methylation is well established as a diagnostic marker, and in this study, we find that GSTP1 methylation levels are also associated with disease prognosis. Further research is required into the clinical utility of prognostic methylation markers and their functional role in disease progression.