bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diseño de una ruta pedagógica para la evaluación de competencias a través del portfolio electrónico en entornos distribuidos y heterogéneos de aprendizaje/Design of a pedagogical route for the evaluation of competencies through the electronic portfolio in distributed and heterogenous environments of learning
Authors: Quintana Marín Sofía , Montero Cádiz Manuel Medardo , Recio Vázquez Roberto , Páez Páez Jaime Alberto , Cortés Méndez Jairo Augusto 
Published: January 2019

RESUMENEl presente artículo da cuenta de la ruta pedagógica para la evaluación de competencias a través de portfolios electrónicos en ambientes heterogéneos y distribuidos de aprendizaje dentro de la segunda fase de una investigación realizada por la Universidad de Valladolid y la Universidad Cooperativa de Colombia con estudiantes y profesores en dos ciudades. Se emplea el método ADRION con un enfoque interdisciplinario que articulan los campos de la ingeniería y la educación. En la primera fase se diseñaron y ejecutaron situaciones de aprendizaje en ambientes heterogéneos y distribuidos con la plataforma ILDE para estudiantes universitarios en cuatro grupos de diferentes campos de conocimiento (Cortes, Paez, Quintana, Recio, & Montero, 2017). A partir de los resultados se identifican los elementos con las que se configura la propuesta que aquí se presenta, en la que se resalta la evaluación como punto de partida para la enseñanza, con miras al desarrollo de las competencias, transversalizada por la intersubjetividad, lo que favorece la consolidación de comunidades de práctica que al mismo tiempo aporta a la cualificación de los profesores y al mejoramiento de la calidad educativa. ABSTRACTThis article shows the pedagogical route for the evaluation of competencies through electronic portfolios in heterogenous and distributed learning environments inside the second phase of the research completed with students and professors by the Universidad de Valladolid and the Universidad Cooperativa de Colombia in two cities. The method implemented is ADRION and it is used with interdisciplinary focus whereas the field of engineering and the field of education are articulated together. In the first phase, situations of learning were designed and accomplished in heterogenous and distributed environments with the ILDE platform into four groups of different fields of knowledge (Cortés, Páez, Quintana, Recio, & Montero, 2017). in the university students. The given results provide the elements from which the proposal is designed and it is presented here. The evaluation highlighted from this proposal offers a starting point for teaching that looks for the develop of competencies, mainstreamed by the intersubjectivity which in favors the consolidation of practicum communities where they provide the qualification pf teachers and the improvement of the quality of education.
La formation documentaire en milieu universitaire
Authors: Laghzali Mohamed 
Published: January 2019

La complexité du système documentaire, les formules pédagogiques nouvelles axées sur l’acquisition des méthodes plutôt que sur la transmission des connaissances, l’explosion de l’information et la sous-utilisation des ressources documentaires par les étudiants rendent indispensable la formation documentaire en milieu universitaire.
L’auteur décrit des programmes et méthodes de formation documentaire et suggère un processus d’implantation basé sur la collaboration entre bibliothécaires et enseignants.
Vers une société sans papier ?
Authors: Lehoux Guylaine 
Published: January 2019

Depuis environ 500 ans, les canaux formels de communication sont, dans une large mesure, basés sur l’imprimé. La société est maintenant appelée à passer de l’imprimé à un système d’édition complètement électronique dans lequel les ordinateurs et les télécommunications seront majoritairement utilisés dans tout le processus de communication.
L’auteure analyse l’impact des nouvelles technologies sur les bibliothèques et jette un regard prospectif sur la bibliothèque du futur et le rôle du bibliothécaire à l’ère de l’électronique.
La politique d’aide au développement des bibliothèques publiques du Québec (1960-1985)
Authors: Gagnon Gilbert 
Published: January 2019

On peut dégager cinq périodes dans l’histoire de la politique d’aide au développement des bibliothèques publiques du Québec depuis 1960. Une première est dominée par la législation et les études préalables à l’implantation d’un système cohérent. La seconde est marquée par l’application des premiers règlements; la troisième, par une remise en question de l’aide financière aux bibliothèques publiques et la quatrième, par l’accélération du développement des bibliothèques municipales et par la création de bibliothèques centrales de prêt. Enfin, en 1985, un plan ambitieux d’amélioration des équipements, des services et du rendement permettra aux bibliothèques de faire un bond en avant.
L’auteur propose ici une approche descriptive des événements observés au cours de ces périodes.
L’ASTED, dix ans après : bilan et prospective
Authors: Rousseau Denis , Perron Hubert 
Published: January 2019

Les auteurs font ressortir les gestes positifs posés par l’Association pour l’avancement des sciences et des techniques de la documentation (ASTED) depuis sa création en 1974 et signalent ses faiblesses et ses omissions. Quatre domaines retiennent leur attention : la formation professionnelle et continue, la coordination des services documentaires, leur « promotion » et la vie de l’Association.
L’information dans les bibliothèques publiques comme nouvel instrument de marketing
Authors: Savard Réjean 
Published: January 2019

Les différents éléments du problème sont présentés et définis : information, besoins d’information, types de besoin. Il est démontré ensuite comment la bibliothèque publique à l’extérieur du Québec s’est développée comme centre d’information. Les possibilités d’implanter ce concept au Québec sont envisagées.
The effect of cycling hypoxia on MCF-7 cancer stem cells and the impact of their microenvironment on angiogenesis using human umbilical vein endothelial cells (HUVECs) as a model
Authors: Alhawarat Fuad M. , Hammad Hana M. , Hijjawi Majd S. , Sharab Ahmad S. , Abuarqoub Duaa A. , Al Shhab Mohammad A. , Zihlif Malek A. 
Published: January 2019

Background
Breast cancer is the most common type of cancer among females. Hypoxia mediates cancer hallmarks and results from reduced oxygen level due to irregularities in tumor vascularization or when the tumor size prevents oxygen diffusion and triggers angiogenesis to compensate for low oxygen. Cancer stem cells (CSCs) are a rare subpopulation, able to self-renew and to give rise to tumor-initiating cells. It is proposed that CSCs’ secretions help to recruit endothelial cells via angiogenic factors to establish tumor vascularization. In the tumor microenvironment, the effect of hypoxia on CSCs and the impact of their secretions on triggering angiogenesis and tumor vascularization remain questionable. In this study, three-dimensional (3D) CSCs derived from MCF-7 were directly exposed to repetitive long-term cycles of hypoxia to assess its effect on CSCs and then to evaluate the role of the hypoxic CSCs’ (CSCsHYP) secretions in angiogenesis using (HUVECs) as a model for tumor neovascularization response.

Methods
CSCs derived from MCF-7 cell-line were expanded under repetitive, strictly optimized, long-term/continuous and intermittent hypoxic shots for almost four months to assess hypoxic effect on CSCs, sorted based on CD44+/CD24− biomarkers. Hypoxic phenotype of CSCsHYP was evaluated by assessing the acquired chemoresistance using MTT assay and elevated stemness properties were assessed by flow cytometry. To evaluate the effect of the secretions from CSCsHYP on angiogenesis, HUVECs were exposed to CSCsHYP conditioned-medium (CdM)—in which CSCs had been previously grown—to mimic the tumor microenvironment and to assess the effect of the secretions from CSCsHYP on the HUVECs’ capability of tube formation, migration and wound healing. Additionally, co-culture of CSCsHYP with HUVECs was performed.

Results
CSCsHYP acquired higher chemoresistance, increased stemness properties and obtained greater propagation, migration, and wound healing capacities, when compared to CSCs in normoxic condition (CSCsNOR). HUVECs’ tube formation and migration abilities were mediated by hypoxic (CSCs) conditioned media (CdM).

Discussion
This study demonstrates that chemoresistant and migrational properties of CSCs are enhanced under hypoxia to a certain extent. The microenvironment of CSCsHYP contributes to tumor angiogenesis and migration. Hypoxia is a key player in tumor angiogenesis mediated by CSCs.
Engineering an Earth‐Abundant Element‐Based Bifunctional Electrocatalyst for Highly Efficient and Durable Overall Water Splitting
Authors: Kang Zhuo , Guo Huijing , Wu Jing , Sun Xu , Zhang Zheng , Liao Qingliang , Zhang Suicai , Si Haonan , Wu Pingwei , Wang Li , Zhang Yue 
Published: January 2019

AbstractThe simultaneous and efficient evolution of hydrogen and oxygen with earth‐abundant, highly active, and robust bifunctional electrocatalysts is a significant concern in water splitting. Herein, non‐noble metal‐based Ni–Co–S bifunctional catalysts with tunable stoichiometry and morphology are realized. The engineering of electronic structure and subsequent morphological design synergistically contributes to significantly elevated electrocatalytic performance. Stable overpotentials (η10) of 243 mV (vs reversible hydrogen electrode) for oxygen evolution reaction (OER) and 80 mV for hydrogen evolution reaction (HER), as well as Tafel slopes of 54.9 mV dec−1 for OER and 58.5 mV dec−1 for HER, are demonstrated. In addition, density functional theory calculations are performed to determine the optimal electronic structure via the electron density differences to verify the enhanced OER activity is related to the Co top site on the (110) surface. Moreover, the tandem bifunctional NiCo2S4 exhibit a required voltage of 1.58 V (J = 10 mA cm−2) for simultaneous OER and HER, and no obvious performance decay is observed after 72 h. When integrated with a GaAs solar cell, the resulting photoassisted water splitting electrolyzer shows a certified solar‐to‐hydrogen efficiency of up to 18.01%, further demonstrating the feasibility of engineering protocols and the promising potential of bifunctional NiCo2S4 for large‐scale overall water splitting.
Manipulation of Charge Transport by Metallic V13O16 Decorated on Bismuth Vanadate Photoelectrochemical Catalyst
Authors: Ren Hangjuan , Dittrich Thomas , Ma Hongyang , Hart Judy N. , Fengler Steffen , Chen Sheng , Li Yibing , Wang Yu , Cao Fuyang , Schieda Mauricio , Ng Yun Hau , Xie Zhirun , Bo Xin , Koshy Pramod , Sheppard Leigh R. , Zhao Chuan , Sorrell Charles C. 
Published: January 2019

AbstractConductive metal oxides represent a new category of functional material with vital importance for many modern applications. The present work introduces a new conductive metal oxide V13O16, which is synthesized via a simplified photoelectrochemical procedure and decorated onto the semiconducting photocatalyst BiVO4 in controlled mass percentages ranging from 25% to 37%. Owing to its excellent conductivity and good compatibility with oxide materials, the metallic V13O16‐decorated BiVO4 hybrid catalyst shows a high photocurrent density of 2.2 ± 0.2 mA cm−2 at 1.23 V versus reversible hydrogen electrode (RHE). Both experimental characterization and density functional theory calculations indicate that the superior photocurrent derives from enhanced charge separation and transfer, resulting from ohmic contact at the interface of mixed phases and superior electrical conductivity from V13O16. A Co–Pi coating on BiVO4–V13O16 further increases the photocurrent to 5.0 ± 0.5 mA cm−2 at 1.23 V versus RHE, which is among the highest reported for BiVO4‐based photoelectrodes. Surface photovoltage and transient photocurrent measurements suggest a charge‐transfer model in which photocurrents are enhanced by improved surface passivation, although the barrier at the Co–Pi/electrolyte interface limits the charge transfer.
Boron‐Containing Probes for Non‐optical High‐Resolution Imaging of Biological Samples
Authors: Kabatas Selda , Agüi‐Gonzalez Paola , Saal Kim‐Ann , Jähne Sebastian , Opazo Felipe , Rizzoli Silvio O. , Phan Nhu T. N. 
Published: January 2019

AbstractBoron has been employed in materials science as a marker for imaging specific structures by electron energy loss spectroscopy (EELS) or secondary ion mass spectrometry (SIMS). It has a strong potential in biological analyses as well; however, the specific coupling of a sufficient number of boron atoms to a biological structure has proven challenging. Herein, we synthesize tags containing closo‐1,2‐dicarbadodecaborane, coupled to soluble peptides, which were integrated in specific proteins by click chemistry in mammalian cells and were also coupled to nanobodies for use in immunocytochemistry experiments. The tags were fully functional in biological samples, as demonstrated by nanoSIMS imaging of cell cultures. The boron signal revealed the protein of interest, while other SIMS channels were used for imaging different positive ions, such as the cellular metal ions. This allows, for the first time, the simultaneous imaging of such ions with a protein of interest and will enable new biological applications in the SIMS field.
Guanidine–Copper Complex Catalyzed Allylic Borylation for the Enantioconvergent Synthesis of Tertiary Cyclic Allylboronates
Authors: Ge Yicen , Cui Xi‐Yang , Tan Siu Min , Jiang Huan , Ren Jingyun , Lee Nicholas , Lee Richmond , Tan Choon‐Hong 
Published: January 2019

AbstractAn enantioconvergent synthesis of chiral cyclic allylboronates from racemic allylic bromides was achieved by using a guanidine–copper catalyst. The allylboronates were obtained with high γ/α regioselectivities (up to 99:1) and enantioselectivities (up to 99 % ee), and could be further transformed into diverse functionalized allylic compounds without erosion of optical purity. Experimental and DFT mechanistic studies support an SN2′ borylation process catalyzed by a monodentate guanidine–copper(I) complex that proceeds through a special direct enantioconvergent transformation mechanism.
Über die besondere Rolle des Stickstoffliganden in den durch [NbN]+ katalysierten Redoxreaktionen von N2O/CO in der Gasphase
Authors: Sun Xiaoyan , Zhou Shaodong , Yue Lei , Guo Cheng , Schlangen Maria , Schwarz Helmut 
Published: January 2019

AbstractDie durch das Übergangsmetallnitrid‐Ion [NbN]+ vermittelte, katalytische Reduktion von N2O durch CO wurde unter thermischen Bedingungen in der Gasphase mittels FT‐ICR‐Massenspektrometrie und quantenchemischen Rechnungen untersucht. Während das [NbN]+/[ONbN]+‐System die Oxidation von CO durch N2O katalysiert, ermöglichen die Systeme [Nb]+/[NbO]+ und [NbO]+/[Nb(O)2]+ zwar die Oxidation von [Nb]+ und [NbO]+ durch N2O, jedoch reagieren weder [NbO]+ noch [Nb(O)2]+ bei Zimmertemperatur mit CO. Die Ursachen dieser durch den Stickstoffliganden hervorgerufenen, deutlich unterschiedlichen Reaktivitäten wurden mit quantenchemischen Rechnungen ermittelt.
Effective synthesis of nanoscale anatase TiO2 single crystals using activated carbon template to enhance the photodegradation of crystal violet
Authors: Gao Zhenzhen , Wu Zhansheng , Chen Xiaoqing , Yang Xia 
Published: January 2019

Nanoscale anatase TiO2 single crystals were successfully synthesized using three kinds of activated carbon (AC) templates through a simple sol–gel method. The optimal photocatalyst (T‐WOAC) was obtained using wood‐based AC template. X‐ray diffraction, transmission electron microscopy and Brunauer–Emmett–Teller analyses revealed that T‐WOAC possessed a small crystallite size of 8.7 nm and a clear mesoporous structure. The photocatalytic properties of samples were then evaluated through photodegradation of crystal violet (CV). Results implied that the photocatalysts prepared using the AC templates exhibited superior photocatalytic activity to that of the original TiO2. This enhancement may be due to the small crystallite size, large specific surface area and pore volume of the catalysts prepared with ACs. T‐WOAC showed high photocatalytic activity, CV degradation of 99.01% after 120 min of irradiation and k = 0.03914 min−1, which is 3.9 times higher than that of the original TiO2 (k = 0.00994 min−1). This result can be mainly attributed to the application of WOAC with moderate specific surface area and pore volume to produce T‐WOAC. Alkaline conditions benefitted the photodegradation of CV over photocatalysts. This work proposes a possible degradation mechanism of CV and indicates that the fabricated photocatalysts can be used to effectively remove CV from aqueous solutions.
The Efficacy of a Lateral Wedge Insole for Painful Medial Knee Osteoarthritis After Prescreening: A Randomized Clinical Trial
Authors: Felson David T. , Parkes Matthew , Carter Suzanne , Liu Anmin , Callaghan Michael J. , Hodgson Richard , Bowes Michael , Jones Richard K. 
Published: January 2019

ObjectiveLateral wedge shoe insoles decrease medial knee loading, but trials have shown no effect on pain in medial knee osteoarthritis (OA). However, loading effects of insoles are inconsistent, and they can increase patellofemoral loading. We undertook this study to investigate the hypothesis that insoles would reduce pain in preselected patients.MethodsAmong patients with painful medial knee OA, we excluded those with patellofemoral OA and those with a pain rating of <4 of a possible 10. We further excluded participants who, in a gait analysis using lateral wedges, did not show at least a 2% reduction in knee adduction moment (KAM), compared to wearing their shoes and a neutral insole. We then randomized subjects to lateral wedge versus neutral insole for 8‐week periods, separated by an 8‐week washout. The primary outcome measure was knee pain (0–10 scale) during the past week, and secondary outcome measures included activity pain and pain rated in the Knee Injury and Osteoarthritis Outcome Score questionnaire. We carried out mixed model analyses adjusted for baseline pain.ResultsOf 83 participants, 21 (25.3%) were excluded from analysis because of insufficient reduction in KAM. In the 62 patients included in analysis, the mean ± SD age was 64.2 ± 9.1 years, and 37.1% were women. Lateral wedge insoles produced a greater reduction in knee pain than neutral insoles (mean difference of 0.7 on 0–10 scale [95% confidence interval 0.1, 1.2]) (P = 0.02). Findings for secondary outcome measures were mixed.ConclusionIn participants prescreened to eliminate those with patellofemoral OA and biomechanical nonresponders, lateral wedge insoles reduced knee pain, but the effect of treatment was small and is likely of clinical significance in only a minority of patients. Targeting patients may identify those who respond to this treatment.
Generation of a Core Set of Items to Develop Classification Criteria for Scleroderma Renal Crisis Using Consensus Methodology
Authors: Butler Emily‐Ann , Baron Murray , Fogo Agnes B. , Frech Tracy , Ghossein Cybele , Hachulla Eric , Hoa Sabrina , Johnson Sindhu R. , Khanna Dinesh , Mouthon Luc , Nikpour Mandana , Proudman Susanna , Steen Virginia , Stern Edward , Varga John , Denton Christopher , Hudson Marie ,   the Scleroderma Clinical Trials Consortium Scleroderma Renal Crisis Working Group
Published: January 2019

ObjectiveTo generate a core set of items to develop classification criteria for scleroderma renal crisis (SRC) using consensus methodology.MethodsAn international, multidisciplinary panel of experts was invited to participate in a 3‐round Delphi exercise developed using a survey based on items identified by a scoping review. In round 1, participants were asked to identify omissions and clarify ambiguities regarding the items in the survey. In round 2, participants were asked to rate the validity and feasibility of the items using Likert‐type scales ranging from 1 to 9 (where 1 = very invalid/unfeasible, 5 = uncertain, and 9 = very valid/feasible). In round 3, participants reviewed the results and comments from round 2 and were asked to provide final ratings. Items rated as highly valid and feasible (median scores ≥7 for each) in round 3 were selected as the provisional core set of items. A consensus meeting using a nominal group technique was conducted to further reduce the core set of items.ResultsNinety‐nine experts from 16 countries participated in the Delphi exercise. Of the 31 items in the survey, consensus was achieved on 13, in the categories hypertension, renal insufficiency, proteinuria, and hemolysis. Eleven experts took part in the nominal group technique discussion, where consensus was achieved in 5 domains: blood pressure, acute kidney injury, microangiopathic hemolytic anemia, target organ dysfunction, and renal histopathology.ConclusionA core set of items that characterize SRC was identified using consensus methodology. This core set will be used in future data‐driven phases of this project to develop classification criteria for SRC.
Suicidal death within a year of a cancer diagnosis: A population‐based study
Authors: Saad Anas M. , Gad Mohamed M. , Al‐Husseini Muneer J. , AlKhayat Mohamad A. , Rachid Ahmad , Alfaar Ahmad Samir , Hamoda Hesham M. 
Published: January 2019

BackgroundThe suicide risk after a new cancer diagnosis remains a controversial issue. This study examines the suicide risk within the year after a cancer diagnosis. This is the largest study to assess recent trends in suicide risk after a cancer diagnosis.MethodsData were obtained from the Surveillance, Epidemiology, and End Results Program. All patients diagnosed with cancer between 2000 and 2014 were selected. The event was defined as death due to suicide within the first year after a cancer diagnosis, and patients who experienced the event after their diagnosis were observed. The observed/expected (O/E) ratio was assessed as well as the excess risk per 10,000 person‐years to determine the suicide risk change after the diagnosis in comparison with the general population.ResultsA total of 4,671,989 patients with cancer were included; 1585 committed suicide within 1 year of their diagnosis. The risk of suicide increased significantly with an O/E ratio of 2.52 and with an excess risk of 2.51 per 10,000 person‐years. When the risk of suicide was studied according to the cancer site, the highest increases in the O/E ratio came after diagnoses of pancreatic cancer (8.01) and lung cancer (6.05). The risk of suicide also increased significantly after a diagnosis of colorectal cancer with an O/E ratio of 2.08. However, the risk of suicidal death did not increase significantly after breast and prostate cancer diagnoses.ConclusionsThe risk of suicide increases significantly in the first year after a diagnosis of cancer in comparison with the general population, and this increase varies with the type and prognosis of cancer. Close observation and referral to mental health services, when indicated, are important for mitigating such risk.
Synthesis, structures, and reactivity of 9,9‐dialkoxy‐9‐silafluorenes
Authors: Kanno Ken‐ichiro , Hirose Satoshi , Kyushin Soichiro 
Published: January 2019

AbstractA series of novel 9,9‐dialkoxy‐9‐silafluorenes were synthesized, and their structures and reactivity were studied. Dehydrogenative alkoxylation of 9,9‐dihydro‐9‐silafluorene with various alcohols in the presence of PdCl2 gave the corresponding dialkoxylated products in good yields. The structures of some of the novel 9,9‐dialkoxy‐9‐silafluorenes were analyzed by X‐ray crystallography. The 9,9‐dialkoxy‐9‐silafluorenes show remarkably high reactivity toward phenylmagnesium bromide to afford substitution products.