bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Impairment Related to ADHD From Preschool to School Age
Authors: Overgaard Kristin Romvig , Oerbeck Beate , Friis Svein , Pripp Are Hugo , Aase Heidi , Ingeborgrud Christine Baalsrud , Biele Guido 
Published: December 2024

Objective: Children with ADHD often experience functional impairments across various aspects of daily life. This study addresses the dearth of longitudinal research on functional impairment trajectories from preschool to school age in children with symptoms of ADHD and comorbid disorders. Methods: We investigated the extent to which functional impairments were associated with ADHD symptoms, along with behavioral and anxiety symptoms, from age 3.5 to 8 years. Utilizing parent- and teacher-reported data, we analyzed associations between global impairment, and dimension scores (e.g., family; child quality of life (QoL); learning; play/leisure activities; and friends) and symptoms at ages 3.5 and 8 years ( n = 783). Results: The mean parent global impairment score increased from 0.31 (standard deviation ( SD) = 0.40) to 0.83 ( SD = 0.63) from 3.5 to 8 years, while the teacher impairment scores slightly decreased. Specific parent impairment dimension scores, particularly QoL, learning, and friends, significantly increased. Preschool ADHD and comorbid behavioral symptoms reported by parents weakly predicted impairment at 8 years. By age 8 years, impairment and symptoms exhibited moderate to strong correlations for all impairment dimensions. Parents reported greater child impairment during school age across settings compared to preschool, while teachers’ impairment profiles remained consistent across ages. Conclusions: These findings suggest that parents perceive impairment as more pronounced at age 8 years and more strongly associated with symptoms of both ADHD and comorbid disorders than at age 3.5 years. Notably, for teachers, a robust correlation between inattention symptoms and learning impairment was observed, with substantially higher impairment scores reported for boys compared to girls.
Optimized control of gas temperature and relative humidity during non-invasive respiratory support in preterm infants: A simple and low-cost intervention
Authors: Segatto Karina , Weigert Renata Monteiro , da Silveira Mariane Ferreira , Frâncio Fabiano , Salvagni Kelen , Silva Simone Caldeira , Martins Marba Sergio Tadeu , Sant’Anna Guilherme 
Published: December 2024

Background: During non-invasive respiratory support, administration of gases at high flow rates requires proper air conditioning to avoid upper airways complications. However, closed-loop control of temperature & relative humidity (T&RH) of mixed gases systems with wired-heated circuits are not commonly available in low-middle income countries (LMIC). Thus, a policy for close control of gas T&RH to overcome our system limitations was implemented. The objective of this study was to evaluate the impact of this intervention. Method: Single center retrospective study including preterm infants admitted to a level II unit (June 2019–2020). Close control of gas T&RH was implemented in Dec 2019 and consisted of starting with the heater at a set number higher than previously and followed by adjustments every 6 h based on intermittent temperature checks (target: 36.5°C–37°C). Humidity was controlled by adjusting the water level every 6 h and checking for the presence of condensation. Two groups were identified: infants treated with or without the close T&RH control. Primary outcome was the occurrence of nasal bleeding. Secondary outcomes were adherence to the policy, need to change the original mode of respiratory support or endotracheal intubation. Appropriate statistical tests were applied. Results: A total of 128 neonates were included: 63 managed without and 65 with close gas T&RH control. Rates of nasal bleeding decreased significantly with the close T&RH control, from 30% to 14% ( p = 0.026) despite longer duration of non-invasive support (CPAP: 1.8 ± 1.9 vs 4.3 ± 5.8 days; p = 0.002 and NIPPV: 1.8 ± 1.4 vs 4.2 ± 5.2; p = 0.009). Adherence to the policy was 93%. Changes of the original mode of respiratory support also decreased significantly (14% vs 3%; 0.024) with no intubation. Conclusion: In the absence of advanced and expensive systems, a simple and low-cost intervention to optimize gas T&RH during non-invasive respiratory support in LMIC is feasible and associated with clinical improvements.
Anterior Cruciate Ligament Hybrid Remnant Preserving Reconstruction With Bone–Patellar Tendon–Bone Autograft: A Surgical Technique Video
Authors: Moutzouros Vasilios , Castle Joshua P. , Kasto Johnny , Gasparro Matthew , Pratt Brittaney A. 
Published: December 2024

Background: Anterior cruciate ligament (ACL) ruptures occur frequently, with ACL reconstruction among the most commonly performed orthopaedic sports surgeries. The remnant ACL is typically debrided for visualization. However, further evidence has suggested that this remnant tissue contains a wealth of proprioceptive nerve fibers and a vascular blood supply. Theoretically, preserving the ACL remnant may improve joint proprioception and graft synovialization. Therefore, ACL hybrid remnant preservation reconstruction (HRPR) was developed to preserve and tension the native remnant in combination with an ACL reconstruction. Indications: Patients with proximal tears or femoral-sided avulsions, Sherman type 1 or 2, may be indicated for ACL-HRPR. Technique Description: In this technique, we use a bone–patellar tendon–bone (BTB) autograft, which can be harvested based on the surgeon's preference. After performing a diagnostic arthroscopy, the notch of the knee is debrided, with care to preserve the tibial ACL remnant. The tibial remnant is then undermined with electrocautery. Nonabsorbable suture is passed through the remnant tissue. A tibial guide is placed, and a pin is drilled just posterior to the tibial insertion. Next, the appropriately sized tibial tunnel is drilled just posterior to the tibial remnant insertion. Using an anteromedial-portal technique with the knee maximally flexed, an over-the-top guide with appropriate offset is used to insert the guide pin, and the femoral tunnel is drilled. The proximal graft bone block and the remnant sutures are then passed through the femoral tunnel. Metal screws are then inserted to fix the BTB graft bone blocks on the femoral side, followed by the tibial side. Backup fixation is also used by placing a biocomposite anchor 1 cm distal to the tibial tunnel. Results: A myriad of techniques exist for preserving the ACL remnant. For the present surgical technique, a retrospective cohort revealed that patients undergoing ACL-HRPR achieved full range of motion without extension loss and equivalent patient-reported outcomes, without increased complication rates. Discussion/Conclusions: For patients with femoral-sided ACL tears or avulsion, ACL-HRPR is a viable option that may augment traditional ACL reconstruction. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Degradation of logs installed underground for a half century and the microbial communities involved
Authors: Horisawa Sakae , Okano Daiki , Igarashi Chikai , Hara Tadashi , Matsuhashi Toshiaki 
Published: December 2024

AbstractThe use of wood in civil engineering projects is attractive from the perspective of utilizing renewable materials and reducing CO2 emissions. Furthermore, civil engineering presents an appealing opportunity to expand the demand for wood. Wood degradation rates are low in anaerobic environments, such as underground conditions. In this study, the degradation of wood after 55 years in an underground environment was examined by analyzing logs that had been driven underground for a soil stabilization project. Log density was measured and wood cell walls were observed under a microscope to estimate the degree of degradation, and the bacterial and fungal communities living in the sapwood of the logs were examined using a metagenomic approach. The results showed that the wood density was hardly reduced, and that anaerobic cellulolytic bacteria were dominant in the microbial communities in the wood. The degree of wood degradation over 55 years was low, indicating that these logs retained their ground improvement function for at least half a century.
Evolving research themes in six selected wood science journals: insights from text mining and latent dirichlet allocation
Authors: Hwang Sung-Wook , Lee Won-Hee 
Published: December 2024

AbstractThis study analyzes the status, trends, and future directions in wood science research using text-mining techniques. We applied these techniques to a textual dataset constructed from metadata of six major wood science journals, covering the period from 2002 to 2024. The research explores publication trends, international collaborations, keywords, and research networks, and it employs topic modeling using the Latent Dirichlet Allocation model. The descriptive analysis reveals a consistent increase in publication volume throughout the study period, unaffected by the COVID-19 pandemic. In contrast, international collaboration declined after 2020, likely due to the pandemic. In addition, a network analysis identified key research areas, including surface treatments, structural composites, and high-performance wood products, with lignin, mechanical properties, and moisture content emerging as central keywords. Topic modeling reveals a growing interest in wood modification technologies and an increased focus on studying wood as a sustainable material. The study confirms a shift of the field towards sustainable innovations while also highlighting the enduring relevance of traditional research areas. Future research should adapt to these evolving trends and address emerging challenges to maximize the potential of wood for carbon neutrality and sustainable development. This analysis provides a concise overview of current research trends and future directions in wood science.
Acid-sensing ion channel-1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2
Authors: Wu Zuomeng , Han Tianyu , Dong Yixiang , Ying Wang , Fang Huang , Liu Yunlei , Song Peiwen , Shen Cailiang 
Published: December 2024

Abstract
Background
Traumatic injuries to spinal cord lead to severe motor, sensory, and autonomic dysfunction. The accumulation of inhibitory compounds plays a pivotal role in the secondary damage to sparing neural tissue and the failure of axonal regeneration and remyelination. Acid-sensing ion channel-1(ASIC1A) is widely activated following neurotrauma, including spinal cord injury (SCI). However, its role in SCI remains elusive.

Methods
The effects of acidic environment on the differentiation and genes changes of neural stem cells (NSCs) were assessed by immunofluorescence staining and RNA-sequencing analysis, respectively. The expression of ASIC1A and prostaglandin endoperoxide synthase 2 (PTGS2) were detected by western blot and immunofluorescence staining. The concentration of prostaglandin E2 (PGE2) within NSC-derived extracellular vesicles were evaluated by ELISA. Small-interfering RNAs (siRNAs) were used to knock down Asic1a and Ptgs2 expression in NSCs. The myelin sheath regeneration and axonal remyelination in rats and Asic1a-KO mice were assessed by immunofluorescence staining.

Results
Following injury to the spinal cord, ASIC1A was found to be colocalized and upregulated in NSCs. ASIC1A activation prevents the differentiation of NSCs into oligodendrocytes by upregulating PTGS2, which leads to increased production and release of PGE2 within extracellular vesicles (EVs). ASIC1A or PTGS2 deficiency in NSCs counters the ASIC1A-related effects on mediating NSC differentiation by reducing PGE2 expression within NSC-derived EVs. Furthermore, intervention in ASIC1A signaling by administration of ASIC1A inhibitors or genetic deletion of ASIC1A demonstrated a pronounced advantage in enhancing myelin sheath regeneration and axonal remyelination.

Conclusions
The activation of ASIC1A prevents NSC differentiation into oligodendrocytes via the transcellular NSC-to-NSC delivery of PGE2, resulting in the failure of myelin sheath regeneration and axonal remyelination following SCI. The inhibition of ASIC1A presents a promising therapeutic strategy for the treatment of SCI.

Graphical Abstract
Changing patterns of family formation among internally displaced populations in Yemen: evidence from cross-sectional surveys
Authors: Elnakib Shatha , Zimmerman Linnea A. , Attal Bothaina , Alkebsi Tareq , Aldaram Aisha , Al Kaff Abdullah , Mieth Kate , Robinson Court 
Published: December 2024

Abstract

Introduction
: Yemen has one of the highest rates of child marriage in the Middle East and North Africa region and is home to one of the world’s worst humanitarian crises. How the conflict and resulting displacement have impacted family formation patterns is not entirely clear. In this study, we investigate the impact of displacement on child marriage and early childbearing by comparing time-to-first-marriage and time-to-first-birth among displaced and non-displaced girls.

Methods
We used data collected through cross-sectional multistage stratified cluster household surveys in three governorates in Yemen with high concentrations of internally displaced persons (IDPs). Employing an analytic sample 1,861 girls aged 15–24, we compared entry into first marriage and time to first birth between IDPs and non-displaced persons using Kaplan Meier curves and Cox regressions.

Results
We found high rates of child marriage in this population, with 37.8% and 34.5% of ever-displaced and never-displaced girls aged 20–24 married before age 18. Overall, those who were displaced had 30% higher hazard of overall marriage compared to their host counterparts (95% CI 1.16–1.47), and 23% increased hazard of child marriage (95%CI 1.01–1.51). Stratification by governorate revealed heterogeneity across governorates, with displaced populations at higher hazard of marriage in Aden and Maarib but not in Hadramout. We found that child brides and displaced participants were more likely to initiate earlier childbearing compared to non-child brides (HR = 3.44; 95% CI 2.94 4.0) and host counterparts (HR 1.35; 95% CI 1.15–1.58). Despite generally having lower age at first birth, child brides experienced a 19% lower hazard of first birth after marriage compared to those married over 18, indicating that child brides tended to wait longer before first birth (95% CI 0.72–0.92). We did not find a significant association between displacement status and marriage to birth interval after adjusting for child marriage status.

Conclusion
Our results highlight the impact of forced displacement on time-to-first-marriage and suggest that those who are displaced are more vulnerable to child marriage. We did not find compelling evidence for child marriage driving an increase in early childbearing. Nonetheless, our findings highlight the need for interventions that focus on prevention and mitigation of child marriage in this setting, particularly among IDPs who are at increased vulnerability.
Modern anatomical locking plates are associated with increased postoperative wound complications and unplanned surgical revisions compared to standard tubular plates in the management of unstable ankle fractures: a comparative cohort study in 595 patients
Authors: Gahr Patrick , Matthis Manuel , Schleese Lennart , Fischer Dagmar-C. , Mittlmeier Thomas 
Published: December 2024

Abstract
Background
The clinical benefit of locking plates in distal fibula fractures has not yet been proven. In addition, the risk of wound complications appears to be higher than with conventional tubular plates. We hypothesize that the benefits of locking plates in terms of biomechanical properties are outweighed by a higher risk of wound complications.

Methods
We conducted a retrospective review of fibula fractures treated by osteosynthesis with either a conventional one-third tubular plate or an anatomically shaped locking plate from January 1, 2015 to December 31, 2021. We recorded baseline data and relevant comorbidities and defined the need for revision surgery due to wound-related or mechanical complications as primary endpoints.

Results
A total of 595 out of 727 patients were eligible for our study. Of these 595 fractures, 526 were fixed with a one-third tubular plate, 69 with a locking plate. Revision surgery was required in 54 patients, in 51 cases due to wound complications. Three patients required revision surgery for mechanical reasons and all of them were younger than 40 years of age, have not been diagnosed with osteoporosis, but experienced complex fracture types. As the third tubular plate and locking plate groups differed in terms of age and comorbidities, we performed a 2:1 matching based on age and gender, leaving data from 138 patients receiving a third tubular plate. While the two groups were comparable in many aspects, the rate of wound complications was significantly higher in the locking plate group. Although the locking plate group had a higher percentage of diabetes mellitus, there was no correlation between this comorbidity and the higher revision rate in this group.

Conclusions
Our data do not support the general use of locking plates in the treatment of distal fibular fractures. The risk of mechanical complications in osteoporotic ankle fractures seems to be overrated, as there were no mechanical revisions in the osteoporotic subgroup. The rate of wound-related revision surgery was significantly higher after the use of locking plates. This might be attributed to the greater thickness of locking plates.
Necroptosis contributes to deoxynivalenol-induced liver injury and inflammation in weaned piglets
Authors: Xu Qilong , Gong Hanqiu , Zhou Mohan , Guo Junjie , Chen Shaokui , Xiao Kan , Liu Yulan 
Published: December 2024

Abstract
Background
The aim of this study was to investigate the role of necroptosis in deoxynivalenol (DON)-induced liver injury and inflammation in weaned piglets.

Methods
In Exp. 1, 12 weaned piglets were divided into 2 groups including pigs fed basal diet and pigs fed diet contaminated with 4 mg/kg DON for 21 d. In Exp. 2, 12 weaned piglets were divided into 2 groups including control piglets and piglets given a gavage of 2 mg/kg body weight (BW) DON. In Exp. 3, 24 weaned piglets were used in a 2 × 2 factorial design and the main factors including necrostatin-1 (Nec-1) (DMSO or 0.5 mg/kg BW Nec-1) and DON challenge (saline or 2 mg/kg BW DON gavage). On 21 d in Exp. 1, or at 6 h post DON gavage in Exp. 2 and 3, pigs were killed for blood samples and liver tissues. Liver histology, blood biochemical indicators, and liver inflammation and necroptosis signals were tested.

Results
Dietary or oral gavage with DON caused liver morphological damage in piglets. Dietary DON led to hepatocyte damage indicated by increased aspartate transaminase (AST) activity and AST/alanine aminotransferase (ALT) ratio, and DON gavage also caused hepatocyte damage and cholestasis indicated by increased AST and alkaline phosphatase (AKP) activities. Dietary DON caused liver necroptosis indicated by increased protein abundance of total receptor interacting protein kinase 3 (t-RIP3) and total mixed lineage kinase domain-like protein (t-MLKL). Moreover, DON gavage increased mRNA expression of interleukin (IL)-6 and IL-1β in liver. DON gavage also induced liver necroptosis demonstrated by increased protein abundance of t-RIP3, phosphorylated-RIP3 (p-RIP3), t-MLKL and p-MLKL. However, pretreatment with Nec-1, a specific inhibitor of necroptosis, inhibited liver necroptosis indicated by decreased protein expression of t-RIP3, p-RIP3, t-MLKL and p-MLKL. Nec-1 pretreatment reduced liver morphological damage after DON gavage. Pretreatment with Nec-1 also attenuated liver damage induced by DON indicated by decreased activities of AST and AKP. Furthermore, Nec-1 pretreatment inhibited liver mRNA expression of IL-6 and IL-1β after DON challenge.

Conclusions
Our data demonstrate for the first time that necroptosis contributes to DON-induced liver injury and inflammation in piglets.
The differential role of AI-operated WCF in L2 students’ noticing of errors and its impact on writing scores
Authors: ElEbyary Khaled , Shabara Ramy , Boraie Deena 
Published: December 2024

AbstractDespite the plethora of studies on the role of noticing in second language learning, little is known about the role of AI-operated feedback in noticing errors and uptake during and after writing. To address this gap, this study primarily aimed to investigate the impact of feedback modes and timing on L2 students’ noticing of errors and writing scores. In pursuit of this objective, a quasi-experimental design was adopted in which 75 university undergraduate EFL participants were randomly distributed into four groups representing four feedback conditions. These included receiving feedback (a) from Grammarly while composing, (b) from E-rater after composing, (c) from the teacher after composing, and (d) a no feedback condition. Three argumentative prompts taken from IELTS task 2 were used as writing tasks and Noticing Sheets (NSs) were employed in recording and analyzing participants’ noticing. The findings generally demonstrate that participants exhibited increased noticing with teacher input compared to AI-operated feedback from Grammarly and E-rater, yet they still noticed errors when using the AI systems during and after writing. The results also show that noticing occurred in all feedback conditions, including the fourth one which involved no feedback from any source. This suggests that feedback is not an absolute prerequisite for noticing, but the source and timing of such corrective feedback can influence students’ noticing focus and intensity. The study provides further insights into the role of noticing in L2 learning and offers practical implications for teachers seeking to optimize conventional and automated feedback strategies for enhanced language learning.