bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-Time Detection of Behavioral Anomalies of Older People Using Artificial Intelligence (The 3-PEGASE Study): Protocol for a Real-Life Prospective Trial
Authors: Piau Antoine , Lepage Benoit , Bernon Carole , Gleizes Marie-Pierre , Nourhashemi Fati 
Published: July 2019

Background
Most frail older persons are living at home, and we face difficulties in achieving seamless monitoring to detect adverse health changes. Even more important, this lack of follow-up could have a negative impact on the living choices made by older individuals and their care partners. People could give up their homes for the more reassuring environment of a medicalized living facility. We have developed a low-cost unobtrusive sensor-based solution to trigger automatic alerts in case of an acute event or subtle changes over time. It could facilitate older adults’ follow-up in their own homes, and thus support independent living.

Objective
The primary objective of this prospective open-label study is to evaluate the relevance of the automatic alerts generated by our artificial intelligence–driven monitoring solution as judged by the recipients: older adults, caregivers, and professional support workers. The secondary objective is to evaluate its ability to detect subtle functional and cognitive decline and major medical events.

Methods
The primary outcome will be evaluated for each successive 2-month follow-up period to estimate the progression of our learning algorithm performance over time. In total, 25 frail or disabled participants, aged 75 years and above and living alone in their own homes, will be enrolled for a 6-month follow-up period.

Results
The first phase with 5 participants for a 4-month feasibility period has been completed and the expected completion date for the second phase of the study (20 participants for 6 months) is July 2020.

Conclusions
The originality of our real-life project lies in the choice of the primary outcome and in our user-centered evaluation. We will evaluate the relevance of the alerts and the algorithm performance over time according to the end users. The first-line recipients of the information are the older adults and their care partners rather than health care professionals. Despite the fast pace of electronic health devices development, few studies have addressed the specific everyday needs of older adults and their families.

Trial Registration
ClinicalTrials.gov NCT03484156; https://clinicaltrials.gov/ct2/show/NCT03484156

International Registered Report Identifier (IRRID)
PRR1-10.2196/14245
A NATURAL PRODUCT DECURSIN ENHANCES THE RADIOSENSITIZATION OF IONIZING RADIATION AGAINST DMBA-INDUCED TUMOR
Authors: SHEHZAD ADEEB , ZAHID HIRA , MUHAMMAD WAZIR , AHMAD RIZWAN , AL-SUHAIMI EBTESAM A 
Published: July 2019

Objective: Radiation therapy has gained significant attention for the treatment and prevention of solid and malignant human tumors. However, after periodical exposures, radiation therapy losses its efficacy against cancer cells displaying radio-resistant phenotypes. Therefore, decursin might improve the efficiency of radiotherapy against a variety of human cancers.
Methods: The chemopreventive efficacy of decursin was evaluated against B16F10 cancer cell lines and DMBA/croton oil-induced skin carcinogenesis in BALB/c mice. Decursin was administered intraperitoneal at the dose of 20 mg/kg/day for 8 weeks following exposure to 5 Gy of ionizing radiation (IR) after 1 month of DMBA application. Western blot was performed for underlying mechanism of radioresistance.
Results: Decursin suppressed the proliferation and viability of melanoma cancer cell lines in a concentration- and time-dependent manner. The in vivo data collected from mice model revealed that decursin reduced the precancerous skin lesions and the incidence of tumor bearing in radiation-exposed mice. Decursin also enhanced the effect of IR by downregulation of Akt/NFκB pathway through activation of IκBα.
Conclusion: Our results suggest that the activation of Akt/NFκB establishes a pro-survival response to radiation that may account for the development of radioresistance. Decursin blocks the abnormal expression of these proteins and potentiates the radiotherapeutic effect.
ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITY OF ABELMOSCHUS MANIHOT L. MEDIK LEAF FRACTION AGAINST CCL4-INDUCED LIVER DAMAGE IN RATS
Authors: BANNE YOS , PONIDJAN TATY SETYAWATI , DUMANAUW JOVIE MIEN 
Published: July 2019

Objective: The objective of this research was to determine the antioxidant and hepatoprotective activity of Abelmoschus manihot L. Medik (AMLM) leaves in carbon tetrachloride-induced liver damage in rats (Rattus norvegicus).
Methods: Samples of dried leaf were macerated using 96% ethanol solvent to obtain a viscous extract. Fractionation was then performed using ethyl acetate and n-butanol solvent. The antioxidant activity test of each fraction was done by 1,1-diphenyl-2-picrylhydrazyl assay. For the hepatoprotective activity test, the fractions were suspended in Tween 20 0.4% solution with concentrations of 10 mg/mL and 20 mg/mL. Rats were divided into 6 treatment groups consisting of five rats/group. Group I (positive control) was given an oral suspension of Curcuma® tablet, Group II (negative control) was given Tween 20 0.4% solution, and Groups III and IV (ethyl acetate fraction) and V and VI (n-butanol fraction) were given fraction suspension. On the 1st–7th days, all groups were given the solution treatment, and on the 8th day, all groups were injected with CCl4 intraperitoneally and the treatment was continued until the 11th day. On the 12th day, the blood of rats was taken and then measured the serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT).
Results: The results of the antioxidant test showed that ethyl acetate and n-butanol fraction, respectively, had IC50 of 89.99 and 114.56 ppm.Measurement of SGOT showed the result for Groups I–VI, respectively, of 160±63.62, 260.53±18.98, 154.16±52.78, 177.43±13.70, 120.07±34.80, and 105.23±40.49 IU/L. Measurement of SGPT showed the result for Groups I–VI, respectively, of 101.87±29.24, 108.1±9.04, 57.73±49.05, 106.07±26.45, 66.9±20.05, and 146.63±84.89 UI/L.
Conclusion: The results of this research indicated that the ethyl acetate and n-butanol fraction of AMLM leaves have the antioxidant andhepatoprotective activity.
MECHANISM OF SOLANUM BETACEUM TO PREVENT MEMORY IMPAIRMENT IN CIGARETTE SMOKE-EXPOSED RAT
Authors: KHAERUNNISA SITI , KUSUMASTUTI KURNIA , MUSTIKA ARIFA , AMINAH NANIK SITI , SUHARTATI SUHARTATI 
Published: July 2019

Objective: The aim of this study was conducted to evaluate the neuroprotective role of Solanum betaceum against memory impairment due to chronic cigarette smoke exposure in rat brain.
Methods: Adult male albino rats were exposed to cigarette smoke for 28 days, 3 pc cigarette/day, and simultaneously administered with S. betaceum in Groups K2, K3, and K4 (100 mg/kg b.w/day, 200 mg/kg b.w/day, and 400 mg/kg b.w/day), respectively. The level of N-methyl-D-aspartate (NMDA), c-AMP response element binding (CREB) protein, brain-derived neurotrophic factor (BDNF), number of neuron and glial cells, and memory was also measured.
Results: S. betaceum administration could prevent from memory impairment significantly (p<0.05) by decreased time to reach the target at Y-Maze and maintained the levels of CREB, BDNF, neuron, and glial cells (microglia, astrocytes, and oligodendrocytes) significantly (p<0.05) but did not significantly decreased NMDA levels (p>0.05).
Conclusion: Exposure to cigarette smoke compromised the memory functions. The result of this study shown that administration of S.betaceum could inhibit memory impairment and inhibit the decrease of neuron cells , increase the level of BDNF and number of glia cells including microglia, astrocytes and oligodendrocytes. The mechanism of S. betaceum to prevent memory impairment through activation of CREB (the transcription factor) which further enhances the formation of BDNF (the neurotrophic factors), thus increase activation of the glia cells to protect brain cell damage, thus preventing memory impairment due to cigarette smoke exposure.
A Field Survey of Soil Corrosivity Based on Electrical Resistivity Method
Authors: Zainal Muzakir , Marwan Marwan 
Published: July 2019

Salah satu upaya mitigasi bencana yang perlu dilakukan sebelum pembangunan fasilitas pada kawasan industri yaitu kajian korositivitas tanah. Sifat korositivitas dapat menyebabkan rusaknya infrastruktur bangunan dalam ambang batas tertentu, Kajian korositivitas tanah telah dilakukan pada kawasan industri Kecamatan Julok, Kabupaten Aceh Timur dengan tujuan untuk melakukan investigasi dan pemetaan tingkat korositivitas tanah menggunakan metode resistivitas Wenner 4 pin dan perhitungan pH meter untuk tanah. Akuisisi data dilakukan dengan titik pengukuran sebanyak tujuh titik, dimana setiap titik pengukuran data terdistribusi pada lokasi yang akan digunakan untuk pembangunan industri dengan total panjang lintasan pengukuran 6 km. Hasil pengolahan data resistivitas 1D diperoleh dua jenis pelapisan tanah. Lapisan pertama lebih didominasi oleh kondisi tanah yang tidak korosif dengan nilai resistivitas 20 – 580 Ohm.m. Sedangkan lapisan kedua dapat diduga sebagai lapisan yang korosif dengan nilai resistivitas tanah 5 – 20 Ohm.m. One of the disaster mitigation that needs to be done before facilities development in industrial area is study of soil corrosivity. Within a certain threshold, this corrosivity can cause damage to building infrastructure. This research was done in the industrial area of Julok Subdistrict, East Aceh Regency with the aim of investigating and mapping the level of soil corrosion using a 4-pin Wenner resistivity method and calculating the pH for soil. Data acquisition was carried out at seven measurement point, where each measurement point is distributed at a location that will be used for industrial development with 6 km length. Inversion of resistivity data gives two type of soil layer. The first layer is more complete by non-corrosive soil conditions with resistivity values of 20 - 580 Ohm.m. While the second layer can be interpreted as a corrosive layer with a soil resistivity value of 5-20 Ohm.m. Keywords: korosi, resistivitas, wenner, pH, mitigasi bencana
Precopy Live Migration on Core Network Virtualization Internet Protocol Multimedia Subsystem
Authors: Ahkam Mizanul , Munadi Rizal , Arif Teuku Yuliar 
Published: July 2019

Internet Protocol Multimedia Subsystem (IMS) merupakan suatu arsitektur topologi framework untuk mengirimkan layanan Multimedia berbasiskan IP (Internet Protocol), yang telah menjadi arsitektur framework terkemuka yang sebagai enabler dari operator untuk menawarkan layanan VoIP dan layanan multimedia. Precopy Live Migration merupakan proses migrasi yang diterapkan pada IMS dengan cara page memory pada VM ditransmisikan pada fase iterasi ketika VM sedang dalam state running pada host sumber. Kemudian VM pada sumber di suspend menggunakan fase stop-and-copy dan sisa page memory ditransmisikan menuju host tujuan. Penelitian ini berfokus pada bagaimana IMS tetap dapat melayani pada saat terjadinya migrasi. Downtime yang terlalu lama akan berakibat pada pelayanan dari servis IMS tidak maksimal. Parameter yang akan diuji adalah Downtime, Waktu Migrasi, dan Jumlah data yang di transfer. Internet Protocol Multimedia Subsystem (IMS) is a framework architect topology to delivery multimedia services (Internet Protocol) based which has become the latest architect framework as operator services enabler that provide VoIP and Multimedia services. Precopy Live Migration implemented to IMS with VM’s memory pages are transmitted in the iteration phase, while the VM is still running at the source. After that, the VM is suspended in the stop- and-copy phase, and the remaining pages are transmitted to the destination. This research focused on how IMS can provide user during migration process. Longest downtime process will impact on service level to user. During migration process, Downtime, Migration Time, and Amount transferred data were evaluated. Keywords: downtime, migration, IMS, Virtual, precopy live migration
The Russia-EU perspective: national security and counterterrorism from a different angle
Authors: Malfait Milka 
Published: July 2019

Introduction: Statistics have proven that both the European Union (“EU”) and the Russian Federation (“Russia”) suffer from terrorism in its current form. Intensifying partnerships to combat terrorism would be a good idea. This essay envisages to illustrate a common base for cooperation in the fight against terrorism despite of some general differences in policy and structure between the EU and Russia.Materials and methods: The methodological basis of the research has both an analytical and descriptive nature. As for the analytical nature, sta­tistical, qualitative and comparative analyses were used while researching political phenomena and processes in the sphere of national security and coun­terterrorism. The author also applied the inductive method. The materials observed include the distinct approaches of Russia and the EU in terms of threats to national security including terrorism.Results: The author reveals there are four fundamental issues which ask for more attention in the EU-Russia dialogue on Freedom, Justice and Security and particularly with regard to the fight against terrorism. Firstly, statistics prove that Europe (EU and Russia) are impacted by modern terrorism, yet not by the same cases of terrorism. Secondly, Russia’s experience in counterterrorism is crucial. Thirdly, the scale ‘freedom’ and ‘human rights’ versus ‘security’ has not the same ratio in the EU and in Russia. Fourthly, the concept sovereignty is differently interpreted by the EU, the EU Member States and Russia. Despite all the differences in views, it is clear that the EU could learn a lot from Russia, as one of the key States with considerable experience in the fight against terrorism. Although the EU and Russia face different forms and problems and the roots of Western European terrorism sometimes have a slightly different origin, this does not negate the fact that they could foster cooperation.Discussion and conclusion: The governmental approaches of the EU and Russia on national security were discussed as well as the common grounds for cooperation, namely the threat of terrorism. It is proved that both systems have different features and are not always compatible with each other. The following recommendation of setting up an anti-terrorism working group was provided as well as the advice to eliminate the political distrust.
PERAN KEPERCAYAAN MEREK MEMEDIASI ELECTRONIC WORD OF MOUTH TERHADAP KEPUTUSAN PEMBELIAN
Authors: Dewi Nency Silviana , Sudiksa Ida Bagus 
Published: July 2019

The purpose of this study was to examine the effect of eWOM on purchasing decisions through brand trust in Maybelline product consumers in Denpasar City. The variables examined in this study were eWOM variables, brand trust, and purchasing decisions. The sample size taken is 100 respondents. The method of collecting data in this study through a questionnaire. The analysis technique used is path analysis with classic assumption test and sobel test. Based on the results of the analysis, it was found that eWOM had a positive and significant effect on brand trust, eWOM had a positive and significant effect on purchasing decisions, brand trust positively and significantly influenced purchasing decisions, and brand trust significantly mediated eWOM on Maybelline product purchasing decisions in Denpasar City. Positive eWOM is an effort to increase brand trust. Maintaining brand trust plays an important role in creating product purchasing decisions. Through positive eWOM, consumers are encouraged to immediately make purchasing decisions.
Keywords: electronic word of mouth (eWOM), brand trust, decision
PENGARUH CAPITAL ADEQUACY RATIO, LOAN TO DEPOSIT RATIO, DAN NON PERFORMING LOAN TERHADAP PROFITABILITAS LPD
Authors: Puspita Luh Dina Puspita , Mustanda I Ketut 
Published: July 2019

The purpose of this study is to explain the effect of CAR, LDR, and NPL on the profitability of LPDs in Mengwi District, Badung Regency, 2014-2016. This research was conducted in all LPDs in Mengwi Subdistrict, Badung Regency, 2014-2016. The number of samples used was 38 LPDs used by probability sampling methods with saturated sample techniques. The type of data used is secondary data obtained from the Badung Regency LPD Empowerment Institute for the period 2014-2016. The method of data collection is the non-participant observation method. This study uses multiple linear regression analysis. Based on the results of the analysis of this study indicate that CAR has a positive and significant effect on the profitability of LPD in Mengwi District, Badung Regency. The LDR has negative no significant effect on the profitability of LPDs in Mengwi District, Badung Regency. NPL has negative and significant effect on LPD profitability in Mengwi District, Badung Regency.
Keywords: CAR, LDR, NPL, Profitability
PERAN KEPUASAN KERJA DALAM MEMEDIASI PENGARUH IKLIM ORGANISASI TERHADAP KOMITMEN ORGANISASIONAL
Authors: Jaya I Nyoman Agus Krisna Jaya , Netra I Gusti Salit Ketut 
Published: July 2019

The purpose of this study was to analyze the influence of organizational climate on job satisfaction and organizational commitment, the effect of job satisfaction on organizational commitment, and the influence of organizational climate on organizational commitment through mediating job satisfaction. Based on the results of the analysis it was found that the organizational climate has a positive and significant effect on organizational commitment, organizational climate has a positive and significant effect on job satisfaction, job satisfaction has a significant and significant effect on organizational commitment, and the organizational climate has a positive and significant effect on organizational commitment through mediating job satisfaction. This research was conducted at PT. Toncity Bali Denpasar. The number of samples taken was 42 employees. Data collection is done through interviews and questionnaires. The analysis technique used is path analysis.
Keywords: organizational climate, job satisfaction, organizational commitment
PEMBENTUKAN PORTOFOLIO OPTIMAL MENGGUNAKAN MODEL MARKOWITZ
Authors: Setyawati Ni Putu Eka Cahya , Sudiartha Gede Merta 
Published: July 2019

Investment can be related to investing some funds in financial assets or real assets such as land, gold, shares, deposits, bonds and other forms. As a party who is make an investment, investors will be faced with a variety of options in investing that has a rate of return and risk-appropriate expectations. The ways that usually used by investors is to diversify through the creation of a portfolio. The aim of this research is to know the stocks that can be inserted into the optimal portofolio as well as the proportions of each of the stocks, that the model established by Markowitz. This research was conducted on the IDX30 index from January 2017 to January 2018, especially in the mining sector and consumer goods. The results showed, from 14 stock, 7 stock was selected as candidate of portfolio optimal Markowitz models. Stocks that are worth being a member of the optimal portfolio by a proportion of the allocation of each fund i.e. stocks ADRO (0.55%), ASII (0.15%), GGRM (17.61%), ICBP (9.46%), MEDC (5.275), UNVR (41.11%), and UNTR (25.86%), it gives the expected portfolio return of 3.2% and with the level of risk of 3.3%.
Keywords: optimal portfolio, Markowitz model, mining sector and consumer goods
PENGARUH LINGKUNGAN KERJA NON FISIK DAN KETERLIBATAN ORGANISASIONAL TERHADAP RETENSI KARYAWAN
Authors: Astuti Desak Made Yuni , Dewi A.A. Sagung Kartika 
Published: July 2019

The purpose of this study was to determine the effect of non-physical work environment and organizational involvement on employee retention. This research was conducted at Kumala Hotel Legian Beach. The population of this study was all permanent employees totaling 148 people and using the Slovin formula to obtain a sample of 108 respondents. The sampling technique used in this study is disproportionate stratified random sampling. The method of data collection is done by means of interviews and surveys with tools in the form of questionnaires. The data analysis technique used is multiple linear regression analysis which is processed using SPSS. The results of this study indicate that all research hypotheses are acceptable. Non-physical work environment has a positive and significant effect on employee retention. Organizational involvement has a positive and significant effect on employee retention. The better the non physical work environment and organizational involvement, the higher the employee retention rate.
Keywords: non physical work environment, organizational involvement, employee retention
PENGARUH PROFITABILITAS, STRUKTUR AKTIVA, DAN LIKUIDITAS TERHADAP STRUKTUR MODAL PERUSAHAAN SUBSEKTOR KONSTRUKSI BANGUNAN DI BEI
Authors: Prastika Ni Putu Yulinda , Candradewi Made Reina 
Published: July 2019

This study aims to determine the important factors that can affect the capital structure of companies in the construction construction sub-sector on the Indonesia Stock Exchange (IDX). There are 3 (three) important factors that can affect the capital structure, namely: profitability, asset structure, and liquidity. This research uses purposive sampling in the method of determining the sample so that it gets 9 companies which are the samples of this study. Data used in the form of secondary data taken for 6 years in the period 2012-2017. Multiple linear regression as a data analysis technique used. The results obtained from this study are 1) variable profitability has a significant negative effect on the capital structure of the company's construction construction sub-sector on the Indonesia Stock Exchange (IDX); 2) asset structure has a negative and significant effect on the building construction sub-sector of the company on the IDX; and 3) liquidity has a significant negative effect on the capital structure of the company's construction construction sub-sector on the IDX.
Keywords: capital structure, profitability, asset structure, liquidity
PENGARUH PROFITABILITAS, LIKUIDITAS, DAN TINGKAT PERTUMBUHAN TERHADAP KEBIJAKAN DIVIDEN PADA PERUSAHAAN MANUFAKTUR
Authors: Sari Ni Putu Ayu Sinta Pradnya , Suryantini Ni Putu Santi 
Published: July 2019

ABSTRACT
This study aims to determine the effect of profitability, liquidity and growth rates on dividend policy. The research population was focused on manufacturing companies in the Indonesia Stock Exchange for the period 2013-2017, totaling 139 companies. Based on the sampling criteria with nonprobability sampling method with purposive sampling technique obtained a sample of 22 companies with a time of observation for 5 years, so that the number of observations obtained as many as 110 observations. The analysis technique used in this study is multiple linear regression analysis. The results of the analysis show that profitability and liquidity have a significant positive effect on dividend policy in manufacturing companies on the Indonesia Stock Exchange, while the growth rate has a significant negative effect on dividend policy in manufacturing companies on the Indonesia Stock Exchange.
Keywords: Profitability, liquidity, growth rate, dividend policy