bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Influences Business Academics’ Use of the Association of Business Schools (ABS) List? Evidence From a Survey of UK Academics
Authors: Walker James T. , Fenton Evelyn , Salter Ammon , Salandra Rossella 
Published: April 2018

AbstractThe development of the Association of Business Schools (ABS) list in 2007 and its rapid adoption by UK business schools has had a profound effect on the nature of business and management academics’ ways of working. Using a large‐scale survey of UK business academics, we assess the extent to which individuals use the Academic Journal Guide (AJG/ABS) list in their day‐to‐day professional activities. In particular, we explore how their perceptions of the list, the academic influence of their research, academic rank and organizational context drive the varied use. Building on prior research on the importance of univalent attitudes in predicting behaviour, we find those who haveeitherstrong positive or negative views of the list are more extensive users than those who are ambivalent. We also find that the extent of use of the AJG/ABS list is greatest among those academics who have lower academic influence, in the middle or junior ranks within business schools and in middle and low‐status universities. We explore the implications of these findings for the value of journal rankings and for the management of business schools.
Utility of community‐acquired pneumonia severity scores in guiding disposition from the emergency department: Intensive care or short‐stay unit?
Authors: Williams Julian M , Greenslade Jaimi H , Chu Kevin H , Brown Anthony FT , Lipman Jeffrey 
Published: April 2018

AbstractObjectiveTo assess community‐acquired pneumonia severity scores from two perspectives: (i) prediction of ICU admission or mortality; and (ii) utility of low scores for prediction of discharge within 48 h, potentially indicating suitability for short‐stay unit admission.MethodsPatients with community‐acquired pneumonia were identified from a prospective database of emergency patients admitted with infection. Pneumonia severity index (PSI), CURB‐65, CORB, CURXO, SMARTCOP scores and the Infectious Diseases Society of America/American Thoracic Society (IDSA/ATS) minor criteria were calculated. Diagnostic accuracy statistics (sensitivity, specificity, predictive values, likelihood ratios and area under receiver operating characteristic curves [AUROC]) were determined for both end‐points.ResultsOf 618 patients admitted with community‐acquired pneumonia judged eligible for invasive therapies, 75 (12.1%) were admitted to ICU or deceased at 30 days, and 87 (14.1%) were discharged within 48 h. All scores effectively stratified patients into categories of risk. For prediction of severe pneumonia, SMARTCOP, CURXO and IDSA/ATS discriminated well (AUROC 0.84–0.87). SMARTCOP and CURXO showed optimal sensitivity (85% [95% confidence interval (CI) 75–92]), while specificity was highest for CORB and CURB‐65 (93% and 94%, respectively). Using lowest risk categories for prediction of discharge within 48 h, only SMARTCOP and CURXO showed specificity >80%. PSI demonstrated highest positive predictive value (31% [95% CI 24–39]) and AUROC (0.74 [95% CI 0.69–0.79]).ConclusionsCommunity‐acquired pneumonia severity scores had different strengths; SMARTCOP and CURXO were sensitive with potential to rule out severe disease, while the high specificity of CORB and CURB‐65 facilitated identification of patients at high risk of requirement for ICU. Low severity scores were not useful to identify patients suitable for admission to short‐stay units.
Regulation of carbohydrate degradation pathways in Pseudomonas involves a versatile set of transcriptional regulators
Authors: Udaondo Zulema , Ramos Juan‐Luis , Segura Ana , Krell Tino , Daddaoua Abdelali 
Published: April 2018

SummaryBacteria of the genus Pseudomonas are widespread in nature. In the last decades, members of this genus, especially Pseudomonas aeruginosa and Pseudomonas putida, have acquired great interest because of their interactions with higher organisms. Pseudomonas aeruginosa is an opportunistic pathogen that colonizes the lung of cystic fibrosis patients, while P. putida is a soil bacterium able to establish a positive interaction with the plant rhizosphere. Members of Pseudomonas genus have a robust metabolism for amino acids and organic acids as well as aromatic compounds; however, these microbes metabolize a very limited number of sugars. Interestingly, they have three‐pronged metabolic system to generate 6‐phosphogluconate from glucose suggesting an adaptation to efficiently consume this sugar. This review focuses on the description of the regulatory network of glucose utilization in Pseudomonas, highlighting the differences between P. putida and P. aeruginosa. Most interestingly, It is highlighted a functional link between glucose assimilation and exotoxin A production in P. aeruginosa. The physiological relevance of this connection remains unclear, and it needs to be established whether a similar relationship is also found in other bacteria.
Increased single‐balloon Foley catheter volume for induction of labor and time to delivery: a systematic review and meta‐analysis
Authors: Schoen Corina N. , Saccone Gabriele , Backley Sami , Sandberg Evelien M. , Gu Ning , Delaney Shani , Berghella Vincenzo 
Published: April 2018

AbstractIntroductionInduction of labor is a common intervention. The objective was to investigate whether larger Foley catheter volumes for labor induction decrease the total time from induction to delivery.Material and methodsRandomized controlled trials comparing larger single‐balloon volumes (60–80 mL) during Foley catheter cervical ripening with usual volume (30 mL) in women undergoing labor induction were identified by searching electronic databases (MEDLINE, Scopus, ClinicalTrials.gov, PROSPERO, EMBASE, Scielo and the Cochrane Central Register of Controlled Trials) from inception through 2017. The primary outcome was mean time from induction to delivery in hours. Secondary outcomes included time from induction to vaginal delivery, delivery within 24 h, time to Foley expulsion, cesarean section, chorioamnionitis, epidural use, hemorrhage, meconium staining, and neonatal intensive care unit admission. Meta‐analysis was performed using the random effects model of DerSimonian and Laird (PROSPERO CRD42017058885).ResultsSeven randomized controlled trials including 1432 singleton gestations were included in the systematic review. Women randomized to larger volumes of balloon had a significantly shorter time from induction to delivery (mean difference 1.97 h, 95% CI −3.88 to −0.06). There was no difference in cesarean section between groups (16 vs. 18%, relative risk 0.84, 95% CI 0.6–1.17). A larger balloon volume was associated with a nonsignificant decrease in time from induction to delivery in multiparous (mean difference 2.67 h, 95% CI −6.1 to 0.76) and nulliparous women (mean difference 1.82 h, 95% CI −4.16 to 0.53).ConclusionBalloon volumes larger than 30 mL during Foley catheter induction reduce total time to delivery by approximately 2 h.
Intrapartum fetal death and doctors: a qualitative exploration
Authors: McNamara Karen , Meaney Sarah , O'Donoghue Keelin 
Published: April 2018

AbstractIntroductionThe death of an infant during a pregnancy is profoundly traumatic, both for the parents and for the involved healthcare professionals. Most research focuses on the impact of antenatal stillbirth with very little research examining the specific impact an intrapartum fetal death has on obstetricians. The aim of this study was to provide an in‐depth qualitative exploration of the attitudes and responses that Irish obstetricians have following direct involvement with an intrapartum fetal death.Material and methodsQualitative semi‐structured interviews were used. Interpretative phenomenology was used for data analysis. The setting was a tertiary university maternity unit in Ireland with 8200 deliveries per year. Ten obstetricians were purposively sampled. The main outcome measures were the attitudes and responses of Irish obstetricians following exposure to an intrapartum death.ResultsObstetricians were profoundly and negatively affected by a personal involvement with an intrapartum death. Analysis of the data revealed two superordinate themes; the doctor as a person, and supporting each other. The doctor as person was characterized by two subordinate themes; emotional impact and frustration. Supporting each other was also characterized by two subordinate themes; an unmet need and incidental support and what might work.ConclusionsObstetric doctors who are directly involved in an intrapartum death are the second victims of this event and this is something that needs to be acknowledged by the public, by the healthcare system, by the media and by the doctors themselves. The development of effective emotional support interventions for all obstetricians is extremely important.
Transplantation of Cold Stored Porcine Kidneys After Controlled Oxygenated Rewarming
Authors: Gallinat Anja , Lu Jing , von Horn Charlotte , Kaths Moritz , Ingenwerth Marc , Paul Andreas , Minor Thomas 
Published: April 2018

AbstractThe concept of “controlled oxygenated rewarming” (COR) using ex vivo machine perfusion after cold storage was evaluated as tool to improve renal graft function after transplantation. Renal function after 20 min warm ischemia and 21 h cold storage was studied in an auto‐transplant model in pigs (25–30 kg, n = 6 per group). In the study group, preimplant ex vivo machine perfusion for 90 min was added after cold storage, including gentle warming up of the graft to 20°C (COR). Kidneys that were only cold stored for 21 h served as controls. In vivo follow up was one week; the remaining native kidney was removed during transplantation. COR significantly improved cortical microcirculation upon early reperfusion and reduced free radical mediated injury and cellular apoptosis. Post‐transplant kidney function (peak levels in serum) was also largely and significantly improved in comparison to the control group. A weak inverse correlation was found between renal flow during COR and later peak creatinine after transplantation (r2 = 0.5), better values were seen for oxygen consumption, measured during machine perfusion at 20°C (r2 = 0.81). Gentle graft rewarming prior to transplantation by COR improves post‐transplant graft outcome and may also be a valuable adjunct in pretransplant graft assessment.
Vancomycin‐induced acute kidney injury in elderly Chinese patients: a single‐centre cross‐sectional study
Authors: Pan Kun‐ming , Wu Yi , Chen Can , Chen Zhang‐zhang , Xu Jian‐an , Cao Lei , Xu Qing , Wu Wei , Dai Pei‐fang , Li Xiao‐yu , Lv Qian‐zhou 
Published: April 2018

AimsThe objective of the present study was to investigate the current situation concerning, and risk factors for, vancomycin (VAN)‐induced acute kidney injury (VI‐AKI) in elderly Chinese patients, to assess outcomes and risk factors in patients who have developed VI‐AKI, in order to provide suggestions for improving the prevention and treatment of this condition in these patients.MethodWe retrospectively identified elderly older inpatients who had received four or more doses of VAN treatment. We compared patients with VI‐AKI with those who received VAN treatment and had not developed AKI (NO‐AKI). We defined VI‐AKI as developing AKI during VAN therapy or within 3 days after withdrawal of VAN.ResultsA total of 647 out of 862 elderly inpatients were included in the study. Among those excluded, in 89.3% of cases (192/215) this was because of lack of data on serum creatinine (SCr). Among included patients, 32.5% (210/647) of patients received therapeutic drug monitoring (TDM) during VAN therapy. In 66.9% of cases (424/634), there was insufficient TDM, and in 3.9% (25/634) this was appropriate. A total of 102 patients had confirmed VI‐AKI, with an incidence of 15.8% (102/647). Multiple logistic regression analysis revealed that hyperuricaemia [odds ratio (OR) = 3.045; P = 0.000)], mechanical ventilation (OR = 1.906; P = 0.022) and concomitant vasopressor therapy (OR = 1.919; P = 0.027) were independent risk factors for VI‐AKI; higher serum albumin (OR = 0.885; P = 0.000) was determined to be an independent protective factor for VI‐AKI.ConclusionsFor the elderly Chinese patients treated with VAN, there was insufficient monitoring of SCr, too little use of VAN TDM, and lower rate of patients whose VAN though serum concentrations were not obtained at the correct time. We recommend that hospital managers increase investment in clinical pharmacists, to strengthen professional management. Patients with concomitant hyperuricaemia and on mechanical ventilation and vasopressor therapy should be paid more attention, and a higher serum albumin was determined to be an independent protective factor for VI‐AKI.
Population pharmacokinetics of voriconazole and CYP2C19 polymorphisms for optimizing dosing regimens in renal transplant recipients
Authors: Lin Xiao‐bin , Li Zi‐wei , Yan Miao , Zhang Bi‐kui , Liang Wu , Wang Feng , Xu Ping , Xiang Da‐xiong , Xie Xu‐biao , Yu Shao‐jie , Lan Gong‐bin , Peng Feng‐hua 
Published: April 2018

AimsThe aims of the present study were to characterize the pharmacokinetics of voriconazole in renal transplant recipients and to identify factors significantly affecting pharmacokinetic parameters. We also aimed to explore the optimal dosing regimens for patients who developed invasive fungal infections.MethodsA total of 105 patients (342 concentrations) were included prospectively in a population pharmacokinetic analysis. Nonlinear mixed‐effects models were developed using Phoenix NLME software. Dosing simulations were performed based on the final model.ResultsA one‐compartment model with first‐order absorption and elimination was used to characterize voriconazole pharmacokinetics. Population estimates of clearance, volume of distribution and oral bioavailability were 2.88 l·h−1, 169.3 l and 58%, respectively. The allele frequencies of cytochrome P450 gene (CYP) 2C19*2, *3 and *17 variants were 29.2%, 5.2% and 0.5%, respectively. CYP2C19 genotype had a significant effect on the clearance. Voriconazole trough concentrations in poor metabolizers were significantly higher than in intermediate metabolizers and extensive metabolizers alike. The volume of distribution increased with increased body weight. The oral bioavailability was substantially lower within 1 month after transplantation but increased with postoperative time. Dosing simulations indicated that during the early postoperative period, poor metabolizers could be treated with 150 mg intravenously or 250 mg orally twice daily; intermediate metabolizers with 200 mg intravenously or 350 mg orally twice daily; and extensive metabolizers with 300 mg intravenously twice daily.ConclusionsUsing a combination of CYP2C19 genotype and postoperative time to determine the initial voriconazole dosing regimens followed by therapeutic drug monitoring could help to advance individualized treatment in renal transplantation patients with invasive fungal infections.
The role of temporal patterns in students' behavior for predicting course performance: A comparison of two blended learning courses
Authors: van Leeuwen Anouschka , Bos Nynke , van Ravenswaaij Heleen , van Oostenrijk Jurgen 
Published: April 2018

AbstractIn higher education, many studies have tried to establish which student activities predict achievement in blended courses, with the aim of optimizing course design. In this paper, we examine whether taking into account temporal patterns of student activity and instructional conditions of a course help to explain course performance. A course with a flipped classroom model (FCM) and a course with an enhanced hybrid model (EHM) were compared. The results show that in both cases, a regular pattern of activity is more effective than low activity. In the FCM, initial low activity is detrimental, whereas in the EHM the strategy of cramming later on in the course can still lead to higher course performance. In the FCM, a combination of face‐to‐face and online activity led to sufficient course performance, whereas in the EHM, face‐to‐face or online activity on its own could lead to sufficient course performance. This study offers a methodological and empirical contribution to exploring the role of patterns of activity and instructional conditions for course performance.
Low‐dose‐rate brachytherapy for the treatment of localised prostate cancer in men with a high risk of disease relapse
Authors: Laing Robert , Uribe Jennifer , Uribe‐Lewis Santiago , Money‐Kyrle Julian , Perna Carla , Chintzoglou Stylianos , Khaksar Sara , Langley Stephen E.M. 
Published: April 2018

ObjectivesTo report clinical outcomes of 125I low‐dose‐rate prostate brachytherapy (LDR‐PB) as monotherapy or combined with androgen‐deprivation therapy (ADT) and/or external beam radiotherapy (EBRT) in high‐risk localised prostate cancer.Patients and MethodsAnalysis of clinical outcomes from a prospective cohort of patients treated with LDR‐PB alone or combined treatment in a single institution. Men with a high risk of disease relapse were identified by the National Institute for Health and Care Excellence (NICE) criteria or by the National Comprehensive Cancer Network (NCCN) criteria. Relapse‐free survival (RFS), overall survival (OS), prostate cancer‐specific survival (PCSS), and metastases‐free survival (MFS), were analysed together with patient‐reported symptom scores and physician‐reported adverse events.ResultsThe NICE and NCCN criteria identified 267 and 202 high‐risk patients, respectively. NICE‐defined patients had significantly lower pre‐treatment PSA levels, Gleason scores <7, and a greater proportion of patients who received LDR‐PB monotherapy. At 9 years after implantation RFS was 89% and 87% in the NICE and NCCN groups, respectively (log‐rank P = 0.637), and OS 93% and 94%, respectively (log‐rank P = 0.481). All of the survival estimates were similar between LDR‐PB monotherapy and combined therapies. Cox proportional hazards regression confirmed RFS was similar between the treatment types. Treatment‐related toxicity was also similar between the treatment methods.ConclusionLDR‐PB is effective at controlling localised prostate cancer in patients with a high risk of disease relapse. As the present study was not randomised, it is not possible to define those patients who need the addition of ADT and/or EBRT. However, the NICE criteria appear suitable to define treatment options where patients could benefit from LDR‐PB as monotherapy or combined treatment. This choice should be discussed with the patient taking into account comorbidities and presence of multiple high‐risk factors.
Bird mixed‐species flock formation is driven by low temperatures between and within seasons in a Subtropical Andean‐foothill forest
Authors: Mangini G. Giselle , Areta Juan Ignacio 
Published: April 2018

AbstractAccording to both the predation avoidance and foraging efficiency hypotheses, birds within mixed flocks increase their foraging efficiency and/or can spend more time feeding and less time looking out for predators. These hypotheses predict that birds in mixed flocks obtain benefits. Thus, mixed flock formation could serve as a strategy to cope with difficult conditions imposed on birds such as climatic conditions that ultimately result in a change in predation pressure or food resources. We evaluate the hypotheses that forming part of a flock confers benefits to its members and the associated prediction that birds will take advantage of these benefits and flock more often under cold and dry weather conditions between and within seasons to cope with such conditions. We surveyed the presence of mixed flocks, flocking propensity, number of species and individuals in mixed flocks in the Subtropical Yungas foothill of Argentina, to examine seasonality, flocking behavior of birds and their responses to two climatic variables: temperature and humidity. Bird species presented a higher flocking propensity and mixed flocks occurred more frequently during the dry and cold seasons than during the more benign seasons, and lower values of temperature within seasons triggered the flocking behavior. Although effects between seasons were expected, birds also showed a short‐term response to small changes in temperature within seasons. These results strengthen the ideas proposed by the foraging hypothesis. Although benefits derived from flocking have yet to be determined, whatever they are should be understood in the context of seasonal variation in life‐history traits.
Preventing Unintentional Injuries to Young Children in the Home: Understanding and Influencing Parents’ Safety Practices
Authors: Morrongiello Barbara A. 
Published: April 2018

AbstractUnintentional injuries are the leading cause of preventable deaths for children in most industrialized countries. In this article, I consider research on how parents prevent home injuries to children under 6 years and discuss an intervention aimed at improving parents’ home‐safety practices. Parents of young children use three types of home‐safety practices: teaching about safety, modifying the environment, and supervising. Relying predominantly on teaching increases young children's risk of injury, whereas modifying the environment and supervising protect children and predict fewer injuries. Drawing on evidence about factors that motivate parents’ safety practices, an intervention was developed to improve supervision: The Supervising for Home Safety program positively changed parents’ appraisals about injury and supervision practices. Developing evidence‐based injury‐prevention programs is an effective way to address this national public‐health issue.
Development of Multifaceted Risk Taking and the Relations to Sex Steroid Hormones: A Longitudinal Study
Authors: Peper Jiska S. , Braams Barbara R. , Blankenstein Neeltje E. , Bos Marieke G.N. , Crone Eveline A. 
Published: April 2018

Risk taking is a multidimensional construct. It is currently unclear which aspects of risk‐taking change most during adolescence and if/how sex hormones contribute to risk‐taking tendencies. This study applied a longitudinal design with three time‐points, separated by 2 years, in participants aged 8–29 years (670 observations). The Balloon Analogue Risk Task, a delay discounting task, and various self‐report questionnaires were administered, to measure aspects of risk taking. Longitudinal analyses demonstrated mostly nonlinear age‐related patterns in risk‐taking behavior and approach‐related personality characteristics (peaking in late adolescence). Increased testosterone and estradiol were found to increase risk‐taking behavior and impulsive personality, but decrease avoidance‐like personality. This study demonstrates that risk taking is most pronounced in mid‐to‐late adolescence and suggests that sex hormones accelerate this maturational process.
Clinical implications of food allergen thresholds
Authors: Graham F. , Eigenmann P. A. 
Published: April 2018

SummaryFood allergy has increased in recent decades and has a major impact on patients’ quality of life. There is currently no treatment in routine clinical practice, and patients are often faced with accidental reactions. Precautionary allergen labelling (PAL) has been used by the food industry to attempt to minimize this risk, although not standardized and often ambiguous. Estimating the risk of reacting to traces in foods is complicated by heterogeneous amounts of allergens in foods with precautionary labelling and individual variability in reaction thresholds. In recent years, oral food challenge studies have shown that low individual reaction thresholds do not necessarily correlate with severe reactions, and current understanding of thresholds is evolving with novel low‐dose challenge protocols better adapted to estimate them. Future tools to provide a better estimation of minimal eliciting doses, including basophil activation tests, may improve our management of food‐allergic patients.