bluuebunny/crossref_metadata_2025_split huggingface dataset:
Células-tronco pluripotentes induzidas e edição de genes: avanços tecnológicos da pesquisa em medicina regenerativa e terapia gênica
Authors: Torres Cristiane Batista Bezerra , Pessoa Wagner Soares 
Published: June 2018

A reprogramação gênica de células diferenciadas permitiu a obtenção de células-tronco pluripotentes induzidas (induced pluripotent stem cells – iPSCs) que não apresentam os questionamentos éticos que envolvem as células-tronco embrionárias e nem o risco de rejeição imunológica. A tecnologia do Conjunto de Repetições Palindrômicas Regularmente Espaçadas com Nuclease Associada 9 (CRISPR-Cas9), permite a correção de defeitos genéticos. O presente estudo tem por objetivo revisar as principais questões metodológicas relacionadas às iPSCs e o CRISPR-Cas 9. Realizou-se uma busca eletrônica nas bases de dados LILACS, MEDLINE, PubMed e SciELO, por meio das expressões “induced pluripotent stem cells ” e “CRISPR Cas9”. As iPSCs podem ser expandidas em cultura e diferenciadas em qualquer célula do corpo, consistindo em um modelo útil para a edição de genes com o CRISPR-Cas9, abrindo novas perspectivas na pesquisa em medicina regenerativa e terapia gênica.
Experience of urgent laparoscopy in patients with enhanced risk of operative intervention
Authors: Tutchenko М. І. , Sloneckyi B. І. , Roschin G. G. , Zantaraia Т. М. , Verbytskyi І. V. 
Published: June 2018

Objective. To estimate efficacy of urgent laparoscopy (UL) in patients, suffering acute diseases of abdominal organs (ADAO) and enhanced operative–anesthesiological risk (OAR).
Маterials and methods. Results of diagnosis and treatment of 671 patients with ADAO were analyzed. All the patients were divided into two groups. In the second group (169 patients), comparing with the first group (502 patients), diagnostic complex was widened, using UL.
Results. The UL application in patients, suffering ADAO, have accelerated the pathological process verification by 24,76%, and enhanced the laparoscopic interventions quantity by 35,79%, what was accompanied by reduction of the local complications rate by 6,7%, systemic – by 4,28%, lethality – by 1,77%.
Conclusion. The results obtained witness the expediency of substantiated application of UL in patients, suffering ADAO and OAR.
ECUACIONES Y TABLAS DE VOLUMEN PARA DOS ESPECIES DE Pinus DE LA SIERRA PURHÉPECHA, MICHOACÁN
Authors: Ramos-Uvilla José A. , García-Magaña J. Jesús , Hernández-Ramos Jonathan , García-Cuevas Xavier , Velarde-Ramírez Juan C. , Muñoz-Flores H. Jesús , García Espinoza Guadalupe Geraldine 
Published: June 2018

Uno de los principales problemas que enfrentan los productores forestales es la incógnita de saber cómo estimar el volumen de madera que tienen en su área boscosa, a partir de datos obtenidos de un inventario forestal. Las ecuaciones de volumen y sus expresiones tabuladas son una de las principales herramientas para conocer, de manera confiable, las existencias reales y realizar un manejo sostenible, así como para la gestión forestal. En este contexto, se realizó un estudio para elaborar ecuaciones y tablas de volúmenes para Pinus lawsonii y P. oocarpa en la zona sur de la Sierra Purhépecha. La toma de datos de campo se llevó a cabo mediante el derribo y cubicación de 152 árboles de P. lawsonii y 83 para P. oocarpa. Se ajustaron y compararon los modelos de Schumacher-Hall , Thornber , Spurr con variable combinada aritmética, Spurr con variable combinada logarítmica y Korsun, los cuales presentaron valores de R2 ajustada entre 0.97 a 0.99 estadísticos de Durbin Watson cercanos a 2; la prueba de Shapiro-Wilk muestra una buena distribución de los residuales. Un análisis ponderado concluyó que para la estimación del volumen de árboles en pie, el modelo de Schumacher-Hall fue el de mejor ajuste. La prueba de homogeneidad de varianzas indica que se puede emplear de manera indistinta este modelo para ambas especies.
Position of Impacted Mandibular Third Molar in different Skeletal Facial Types
Authors: Sapkota Manish Raj , Bhatta Shishir , Shrestha Sujita , Shrestha Rabindra Man 
Published: June 2018

Introduction: Variation in growth pattern in different facial forms affect the space available for tooth eruption, therefore the mandibular third molar impaction has correlation with different skeletal facial types.Objective: To determine the position of impacted mandibular third molar in different skeletal facial types in Nepalese samples.Materials & Method: This cross sectional study was carried out on pre-treatment lateral cephalogram and orthopantomogram records of 207 orthodontic patients visiting Kantipur Dental College and Hospital. Age range of the sample was 16-33 years. Various facial forms were determined with the help of mandibular plane angle (SN-GoGn); for which Nemoceph software was used. Beta angle was used to determine the angle of impaction of mandibular third molar. Impaction pattern was classified as per Pell & Gregory and Winter’s system. SPSS version 20 was used for statistical analysis.Result: Overall rate of mandibular third molar impaction was 63.77% (11.11% unilateral and 52.66% bilateral impaction). The most common type of impaction bilaterally was mesioangular based on Winter’s classification, Class II Position B based on Pell & Gregory’s classification. Higher rate of mandibular third molar impaction was found in dolichofacial type of face (49.2%).Conclusion: Decreased mandibular third molar impactions are seen in brachyfacial type compared to mesofacial and dolichofacial types
Multiloop Edgewise Arch-wire Technique for Skeletal Class III Openbite: A Case Report
Authors: Basukala Dharma Laxmi 
Published: June 2018

Skeletal Class III with openbite is one of the most difficult malocclusion to treat orthodontically. Generally, the morphological characteristics of this malocclusion are poor antero-posterior growth of the maxilla or excessive growth of the mandible with high angle. An 18-year-old male had Class III malocclusion with retrognathic maxilla and normal mandible with high angle. All third molars except on fourth quadrant were extracted to eliminate the posterior crowding. Multiloop Edgewise Arch-wire (MEAW) technique was used to upright the mesially inclined buccal teeth and to correct occlusal plane. In nine month time, anterior cross bite and open bite were corrected; normal overjet, overbite and Class I canine relation were achieved.
Evaluasi Efisiensi Proses Crude Oil Dehydration di CGS 5 Lapangan X Provinsi Riau
Authors: Rita1a Novia , Hadi1b Rasyid Gani 
Published: June 2018

CGS 5 Lapangan X memiliki sebuah fasilitas OTP (Oil Treating Plant) yang mana dari hasil analisa perhitungan retention time dalam proses crude oil dehydration diperoleh rata-rata laju alir fluida terproduksi yang diolah sebesar 434.247 bfpd dan retention time aktual rata-rata selama 42,878 jam, sementara retention time berdasarkan desain operasi dengan laju alir fluida terproduksi 440.000 bfpd yaitu selama 22,399 jam. Hasil perhitungan jumlah demulsifier rata-rata yang digunakan di CGS 5 adalah sebesar 102 ppm, dimana hal ini melebihi target yang sudah disepakati yaitu 90 ppm. Berdasarkan hasil evaluasi efisiensi proses crude oil dehydration CGS 5 yang diperoleh, maka seharusnya tidak diperlukan penambahan retention time dan demulsifier karena kadar BS&W di dalam minyak mentah tersebut masih memenuhi standar kualitas yaitu dibawah 1% (batasan kadar BS&W menurut Standar API), dimana rata-rata kandungan BS&W di CGS 5 sebesar 0,54%.
Pengaruh Konsentrasi Surfaktan Anionik Terhadap Salinitas Optimum dalam Mikroemulsi Spontan dengan Sample Minyak Lapangan M
Authors: Widyaningsih Ratna 
Published: June 2018

Formulasi optimum untuk injeksi kimia dapat ditentukan baik dengan pengukuran tegangan antarmuka yang minimum atau dengan uji perilaku daerah 3 fasa. Terkait dengan kurva desaturasi, dimana semakin rendah tegangan antarmuka, maka semakin rendah saturasi minyak sisa. Mikroemulsi tipe III berdasarkan klasifikasi Winsor adalah kondisi dimana tegangan antarmuka berada di posisi terendah dibandingkan dengan tipe I dan tipe II, dimana kondisi ini disebut juga salinitas optimum. Salinitas optimum sangat dipengaruhi oleh interaksi kimia antara surfaktan-minyak dan surfaktan-air. Terkait dengan gradient salinity pada desain injeksi surfaktan, maka target salinitas optimum yang diharapkan haruslah tercapai untuk mengoptimalkan perolehan minyak. Uji kelakuan fasa dengan menggunakan surfaktan anionik dan contoh minyak dari Lapangan M, dilakukan untuk meneliti pengaruh konsentrasi surfaktan terhadap salinitas optimum dan rasio kelarutan air/minyak di dalam mikroemulsi. Pada penelinitian ini, konsentrasi surfaktan anionik percobaan diubah dari 1 wt% menjadi 0,5 wt%. Dari dasil uji coba tersebut, menunjukkan bahwa pengurangan konsentrasi surfaktan anionik menghasilkan penurunan salinitas optimum dari 42.000 ppm menjadi 31.000 ppm. Sedangkan solubilization ratio menunjukkan hasil tidak mengalami perubahan yang signifikan. Dari hasil penelitian ini, diharapkan penggunaan konsentrasi surfaktan yang tepat akan menjadi petunjuk dalam desain injeksi surfaktan yang diharapkan sesuai dengan kondisi salinitas alami air formasi di Lapangan M.
KEBERADAAN DAN KETERSEDIAAN AIR TANAH DI KOTA MAGELANG
Authors: Pratiknyo Puji 
Published: June 2018

Kota Magelang merupakan salah satu kota di Provinsi Jawa Tengah yang perkembangannya relatif cepat di berbagai sektor. Selaras dengan perkembangan Kota Magelang di berbagai sektor tersebut membutuhkan dukungan untuk memenuhi kebutuhan percepatan perkembangan dan kelangsungan kehidupan. Salah satu yang dibutuhkan adalah sumberdaya alam yang berupa air. Karena sumberdaya air permukaan yang jumlahnya terbatas maka perlu dukungan sumber daya air tanah.Dengan menggunakan peta tematik yang menggambarkan kondisi sumber daya air yang ada di Kota Magelang, yaitu Peta Hidrogeologi dan Peta Cekungan Air Tanah, dan dengan metode perhitungan menggunakan rumus Hukum Darcy dapat diketahui keberadaan dan besarnya ketersediaan air tanah.Hasil yang didapatkan adalah bahwa air tanah di Kota Magelang berada pada 2 kelompok akuifer, yaitu: 1). Akuifer dengan sistem aliran melalui ruang antar butir, setempat melalui rekahan dan 2). Akuifer dengan melalui rekahan dan ruang antar butir. Besarnya ketersediaan air tanah di Kota Magelang dengan menggunakan Peta Hidrogeologi berbeda dengan hasil perhitungan ketersediaan air tanah dengan menggunakan Peta Cekungan Air Tanah. Besar ketersediaan air tanah berdasarkan Peta Hidrogeologi adalah 8,04 Juta m3/th. Sedangkan hasil perhitungan ketersediaan air tanah dengan menggunakan Peta Cekungan Air Tanah adalah 9,18 Juta m3/th.
Anti-Gastric Ulcer Activity of the Water Extract from Payawanorn (Pseuderanthemum Palatiferum)
Authors: Inchab Kannika , Khonsung Parirat , Chiranthanut Natthakarn , Kunanusorn Puongtip , Potikanond Saranyapin , Chansakaow Sunee , Panthong Ampai , Sireeratawong Seewaboon 
Published: June 2018

Objective: To examine the anti-gastric ulcer activity of Payawanorn (Psuderanthemum palatiferum) water extract (PPE) in rats.Material and Methods: Evaluation of anti-gastric ulcer activity of PPE was performed using three induced gastric ulcers models: (1) ethanol/hydrochloric acid (EtOH/HCl), (2) restraint water immersion stress and (3) indomethacin. Ulcer indices were determined by microscopic examination (10X). Pylorus ligation and gastric-wall mucus determination were used to investigate the mechanism of anti-gastric ulcer activity of PPE.Results: Oral administration of PPE (150, 300 and 600 mg/kg) significantly inhibited gastric ulcer formation induced by EtOH/HCl, by water immersion restraint stress, and by indomethacin in rats (p-value<0.05). PPE at 600 mg/kg showed a high percent inhibition of gastric ulcer formation in all models. In the pylorus-ligated model, pretreatment with PPE had no effect on pH, acidity output or the gastric acid secretion rate, demonstrating that PPE lacks an anti-secretory effect. Gastric wall mucus was markedly preserved by pretreatment PPE at 600 mg/kg (18.91±2.57 μg alcian blue/g wet stomach) after ethanol-induced ulcer when compared to that the control group (12.38±1.02 μg alcian blue/ g wet stomach).Conclusion: PPE possesses an anti-gastric ulcer effect related to the preservation of gastric mucus, supporting the traditional use of P. palatiferum to treat gastric ulcers.
Pemanfaatan ICT Untuk Pengembangan Perusahaan Kecil dan Menengah di Look at Hijab Bandung
Authors: Alamsyah Doni Purnama , Solihat Ani , Suhendi Hendi , Firmansyah Ricky , Hunaifi Nanang , Mukminin Amirul , Mauliana Phitsa , Ary Maxsi 
Published: June 2018

AbstrakPeranan ICT sangatlah membantu dalam pekerjaan sehari-hari baik organisasi, perusahaan yang berupa unit kecil ataupun perusahaan besar seperti UMKM. Penggunaan ICT dapat dilakukan dengan membangun website company profile perusahaan. UMKM Look at Hibaj merupakan industri kecil di Kota Bandung yang belum optimal menggunakan ICT, sehingga penelitian fokus pada pengabdian melalui pembangunan website company profile untuk UMKM Look at Hijab. Pembangunan website dilakukan melalui metode pengembangan sistem prototyping. Dengan adanya pemanfaatan ICT, permasalahan di Look at Hijab dapat ditangani dengan baik. Website company profile menjadi salah satu sarana pemasaran yang dapat digunakan oleh Look at Hijab dalam menghadapi persaingan dan pertumbungan UMKM di Kota Bandung. Kata Kunci : ICT, UMKM, Company Profile AbstractThe role of ICT is very helpful in the daily work of organizations, companies in the form of small units or large companies such as SMEs. The use of ICT can be done by building company profile company website. SMEs Look at Hijab is a small industry in Bandung that has not been optimally used ICT, so the research focus on devotion through the development of company profile website for SMEs Look at Hijab. Website development is done through method of prototyping system development. With the use of ICT, problems at Look at Hijab can be handled well. Website company profile became one of the marketing tools that can be used by Look at Hijab in the face of competition and growth of SMEs in Bandung. Keywords : ICT, UMKM, Company Profile
Pengaruh Pengguna Transportasi Berkelanjutan Dan Displin Berlalu Lintas Terhadap Dampak Tingkat Keselamatan Berkendara (Safety Riding) Dalam Studi kasus Penumpang Angkutan Umum M.19 Kranji (Bekasi)-PGC (Cililitan)
Authors: Ramadhayanti Ana 
Published: June 2018

Semakin meningkatnya angka perkembangan kecelakaan membuat pihak-pihak yang terkait termasuk kita semakin meningkatkan kewaspadaan dan meningkatkan kedisplinan dalam berlalu lintas. Keselamatan berkendara merupakan hal yang harus diperhatikan oleh setiap orang. Jika kita perhatikan minat masyarakat dalam memilih angkutan umum saat ini masih besar. Meskipun saat ini telah berkembang angukatn modern seperti transjakarta, dan ojek online namun masyarakat umum tetap ada yang memilih angkutan umum. Namun kurangnya safety riding dalam berkendara serta kurang taatnya kedisplinan dalam berlalu lintas menyebabkan sering terjadinya angkutan umum ini menjadi fokus perhatian karena tidak jarang menyebabkan korban tewas dan luka parah. pada kesempatan ini penulis meneliti pengaruh pengguna transportasi berkelanjutan dan displin berlalu lintas terhadap dampak tingkat keselamatan berkendara (safety riding) dalam studi kasus penumpang angkutan umum M.19 Kranji (Bekasi)-PGC (Cililitan). Penelitian ini menggunakan tipe penelitian survei, sedangkan metode penelitian yang digunakan adalah kuantitatif. Penggunaan data yang dilakukan adalah dengan wawancara, kuisioner dan observasi. Penitian ini merupakan penelitian yang memang belum diteliti sebelumnya khususnya dalam pemilihan studi kasus yang memilih angkutan umum M19 Kranji (Bekasi)-PGC (Clilitan) sebagai fokus yang dikaji. Populasi penelitian ini adalah seluruh pengguna angkutan umum M 19 jurusan Kranji (Bekasi) – PGC (Cililitan). Pengambilan sampel dalam penelitian kuantitatif menggunakan simple random sampling dengan teknik undian. Semoga hasil penelitian ini dapat memberikan manfaat khususnya bagi pengendara angkutan agar lebih berwaspada dan taat peraturan dalam berkendara. Dari hasil penelitian didapatkan bahwa hasil penelitian menujukkan terdapat pengaruh yang signifikan antara Transportasi berkelanjutan dan Disiplin Berlalu Lintas terhadap Keselamatan Berkendara.
Analisis Cost-Volume-Profit Kaitannya dengan Perencanaan Laba
Authors: Andriani Rian 
Published: June 2018

Tujuan penelitian ini adalah untuk menganalisis cost, volume, profit Break Event Point dan Margin Of Safety L.A English Course Baleendah Bandung pada kuartal I – IV. Metode penelitian yang digunakan adalah metode penelitian kuntitatif deskriptif. Teknik pengumpulan data menggunakan studi pustaka, observasi, wawancara, dan dokumentasi yang memiliki hubungan dengan pokok permasalahan. Teknik analisis data yang digunakan metode regresi kuadrat terkecil, break event point dan margin of safety. Hasil menunjukan, biaya tertinggi terdapat pada kuartal I, volume penjualan tertinggi terdapat pada kuartal I, laba tertinggi terdapat pada kuartal I, Break Event Point tertinggi terdapat pada kuartal I. Sedangkan Margin of safety (%) tertinggi pada kuartal IV yaitu 91.9%. Masalah yang timbul dalam perencanaan laba yaitu pertama pendapatan L.A English Course naik turun dalam satu tahunnya, kedua kurangnya promosi untuk beberapa program kecuali program regular. Upaya dalam mengatasi masalah yang timbul di L.A English Course yaitu pertama memberikan gratis biaya daftar, dan memberi voucher untuk siswa L.A yang memasukan siswa baru., kedua membagikan brosur, dan menawarkan program L.A. dengan melakukan follow up semua nomor telepon tamu yang pernah berkunjung.
Changes in language white matter tract microarchitecture associated with cognitive deficits in patients with presumed low-grade glioma
Authors: Incekara Fatih , Satoer Djaina , Visch-Brink Evy , Vincent Arnaud , Smits Marion 
Published: June 2018

OBJECTIVEThe authors conducted a study to determine whether cognitive functioning of patients with presumed low-grade glioma is associated with white matter (WM) tract changes.METHODSThe authors included 77 patients with presumed low-grade glioma who underwent awake surgery between 2005 and 2013. Diffusion tensor imaging with deterministic tractography was performed preoperatively to identify the arcuate, inferior frontooccipital, and uncinate fasciculi and to obtain the mean fractional anisotropy (FA) and mean diffusivity per tract. All patients were evaluated preoperatively using an extensive neuropsychological protocol that included assessments of the language, memory, and attention/executive function domains. Linear regression models were used to analyze each cognitive domain and each diffusion tensor imaging metric of the 3 WM tracts.RESULTSSignificant correlations (corrected for multiple testing) were found between FA of the arcuate fasciculus and results of the repetition test for the language domain (β = 0.59, p < 0.0001) and between FA of the inferior frontooccipital fasciculus and results of the imprinting test for the memory domain (β = −0.55, p = 0.002) and the attention test for the attention and executive function domain (β = −0.62, p = 0.006).CONCLUSIONSIn patients with glioma, language deficits in repetition of speech, imprinting, and attention deficits are associated with changes in the microarchitecture of the arcuate and inferior frontooccipital fasciculi.
Clipping aneurysms improves outcomes for patients undergoing coiling
Authors: Anderson Ian A. , Kailaya-Vasan Ahilan , Nelson Richard J. , Tolias Christos M. 
Published: June 2018

OBJECTIVEMost intracranial aneurysms are now treated by endovascular rather than by microsurgical procedures. There is evidence to demonstrate superior outcomes for patients with aneurysmal subarachnoid hemorrhage (aSAH) treated by endovascular techniques. However, some cases continue to require microsurgery. The authors have examined the relationship between the number of aneurysms treated by microsurgery and outcome for patients undergoing treatment for aSAH at neurosurgical centers in England.METHODSThe Neurosurgical National Audit Programme (NNAP) database was used to identify aSAH cases and to provide associated 30-day mortality rates for each of the 24 neurosurgical centers in England. Data were compared for association by regression analysis using the Pearson product-moment correlation coefficient and any associations were tested for statistical significance using the one-way ANOVA test. The NNAP data were validated utilizing a second, independent registry: the British Neurovascular Group’s (BNVG) National Subarachnoid Haemorrhage Database.RESULTSIncreasing numbers of microsurgical cases in a center are associated with lower 30-day mortality rates for all patients treated for aSAH, irrespective of treatment modality (Pearson r = 0.42, p = 0.04), and for patients treated for aSAH by endovascular procedures (Pearson r = 0.42, p = 0.04). The correlations are stronger if all (elective and acute) microsurgical cases are compared with outcome. The BNVG data validated the NNAP data set for patients with aSAH.CONCLUSIONSThere is a statistically significant association between local microsurgical activity and center outcomes for patients with aSAH, even for patients treated endovascularly. The authors postulate that the number of microsurgical cases performed may be a surrogate indicator of closer neurosurgical involvement in the overall management of neurovascular patients and of optimal case selection.
Clinical prediction of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage
Authors: Lee Hubert , Perry Jeffrey J. , English Shane W. , Alkherayf Fahad , Joseph Joanne , Nobile Steven , Zhou Linghong Linda , Lesiuk Howard , Moulton Richard , Agbi Charles , Sinclair John , Dowlatshahi Dar 
Published: June 2018

OBJECTIVEThe aim of this study was to derive a clinically applicable decision rule using clinical, radiological, and laboratory data to predict the development of delayed cerebral ischemia (DCI) in aneurysmal subarachnoid hemorrhage (aSAH) patients.METHODSPatients presenting over a consecutive 9-year period with subarachnoid hemorrhage (SAH) and at least 1 angiographically evident aneurysm were included. Variables significantly associated with DCI in univariate analysis underwent multivariable logistic regression. Using the beta coefficients, points were assigned to each predictor to establish a scoring system with estimated risks. DCI was defined as neurological deterioration attributable to arterial narrowing detected by transcranial Doppler ultrasonography, CT angiography, MR angiography, or catheter angiography, after exclusion of competing diagnoses.RESULTSOf 463 patients, 58% experienced angiographic vasospasm with an overall DCI incidence of 21%. Age, modified Fisher grade, and ruptured aneurysm location were significantly associated with DCI. This combination of predictors had a greater area under the receiver operating characteristic curve than the modified Fisher grade alone (0.73 [95% CI 0.67–0.78] vs 0.66 [95% CI 0.60–0.71]). Patients 70 years or older with modified Fisher grade 0 or 1 SAH and a posterior circulation aneurysm had the lowest risk of DCI at 1.2% (0 points). The highest estimated risk was 38% (17 points) in patients 40–59 years old with modified Fisher grade 4 SAH following rupture of an anterior circulation aneurysm.CONCLUSIONSAmong patients presenting with aSAH, this score-based clinical prediction tool exhibits increased accuracy over the modified Fisher grade alone and may serve as a useful tool to individualize DCI risk.