bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust Control of High-Speed Elevator Transverse Vibration Based on LMI Optimization
Authors: Cao Shunxin , He Qin , Zhang Ruijun 
Published: June 2019

Abstract
Aiming at the problem of transverse vibration of high-speed elevator caused by surface roughness excitation of guide rail and relative motion between car and car frame, firstly, this paper establishes an eight-degree-of-freedom active control model for the transverse vibration of the high-speed elevator separated of car from the car frame. Secondly, the transverse vibration state equation of the high-speed elevator is derived. The H
2 norm is used to minimize the vibration acceleration of the car system. Based on Linear matrix inequality (LMI) optimization technology, a robust controller for the high-speed elevator is designed. Finally, the robust controller is solved by MATLAB and its simulation analysis is carried out. The results show that the vibration of the car and the car frame is inconsistent in actual operation. At the same time, the simulation results also show that the root mean square value, mean value and maximum value of the acceleration of the transverse vibration of the car and the car frame are reduced by more than 19% after using the robust controller. Therefore, the robust controller designed in this paper can effectively suppress the transverse vibration of the vibration car system.
Simulation and Optimization of Temperature Field in Large-Sized MOCVD Reactor by Resistance Heating
Authors: Zhao Lili , Li Zhiming , Guo Runqiu , Feng Lansheng , Lu Ligen , Fu Xiaoqian 
Published: June 2019

Abstract
The effect of the number of layers and the length of the heat shields on the heating efficiency and temperature distributions in the substrate have been studied by establishing the model of a single-piece 18-inch MOCVD reactor. The results show that the number of layers of the heat shields is directly proportional to the heating efficiency, decreasing the length of the thermal shield can reduce the standard deviation(STD) of the substrate temperature. When the length of the heat shields is 56mm, the coefficient of substrate temperature STD is 21.41 °C and the STD is about 45% lower than the traditional susceptor. An area within substrate radius of 200mm, the coefficient of substrate temperature STD is 2.64 °C and the STD is about 93% lower than the traditional susceptor. The results obtained will provide theoretical basis for developing the heating structure of large-sized MOCVD reactor.
Study on Atomization Characteristics of Nozzles in Wet Electrostatic Precipitator
Authors: Xiao Lichun , Wang Xin , Wei Yongpeng , Zhang Meng , Wang Yuchuan 
Published: June 2019

Abstract
Wet electrostatic precipitator (ESP) has been paid more and more attention because of its good collection effect on fine particles in coal-fired power plants. Spraying system is an important part of the wet ESP and its atomization characteristics has an important influence on the collection efficiency. The atomization performance of solid and hollow nozzles was tested under varying pressure. The dust collection efficiency of wet ESP affected by atomization parameters and corona discharge characteristics were studied. Dust removal experiments were carried out by using fly ash from coal-fired power plants. Results show that the best working water pressure of ESP is 0.6 MPa and the atomization effect is best at the same time. Under the same conditions, the dust collection efficiency increased with the decrease of droplets’ diameter and the increase of spray water flow rate. When the droplets’ size is 70 μm, the dust collection efficiency can reach 99.57%, which can meet the high efficiency of fine particles removal in coal-fired power plants.
Design and Analysis of A Multifunctional Wheelchair
Authors: Rui Jin , Gao Qiang 
Published: June 2019

Abstract
Based on existing designs of multifunctional wheelchairs, a new wheelchair designed with body posture adjustment function is proposed to satisfy the needs of the elderly and the disabled. This paper shows the overall design of the wheelchair and the establishment of its 3D model at first; then, the kinematics analysis of the wheelchair’s backrest adjustment mechanism, and verifying the smoothness of its reclining process with establishing a virtual wheelchair prototype for motion simulation in ADAMS; finally, finite element analysis of key components of the wheelchair to make sure their requirements of structural strength.
Numerical Simulation of Deflagration to Detonation Transition in High-Energy Propellant
Authors: Wang Zhuo-qun , Wang Li-qiong , Zhen Fei 
Published: June 2019

Abstract
The deflagration to detonation transition model was established based on AUTODYN/ANSYS to simulate the process of DDT and provide a basis for the safety analysis of high-energy propellant. The process of DDT was numerically simulated by the ignition and growth reactive flow model and ALE method. The detonation pressure, detonation velocity, the run distance and time to detonation were calculated. The simulating results indicate that the detonation velocity is about 2899m/s, the run distance to detonation is about 138.3mm when the density of propellant is 1860kg/m3. The numerical results are in a good agreement with the experimental results.
Self-breathing Technology for Spacecraft Packaging Container Gas Drying Method
Authors: Zhu Yahong , Li Xiaohuan , Meng Shaohua , Zhang Chengli 
Published: June 2019

Abstract
The self-balancing method of packing container is to connect the packing container with the outside world to achieve pressure balance. The gas entering the packing container has been filtered and dried, and the technology of gas filtration has been mature. Under the open environment, the hygroscopicity of hygroscopicity agent needs to be tested. This paper introduces the requirement of hygroscopicant and the test of hygroscopicant under restraint condition, which is used in the design of self-balancing packaging equipment.
Thermal Analysis and Simulation of Cryopump Based on CFD Method
Authors: Zhao Yueshuai , Sun Lichen , Sun Wei , Shao Rongping 
Published: June 2019

Abstract
Based on CFD method, thermal design and numerical simulation of cryopump first array and second array was performed during the cool-down period and the steady state. The analysis of the temperature distribution of the cryopump was made under various conditions, such as operating conditions, the setting of the thermal rods and the thickness of the radiation shield. The const thermal property and variable thermal property was used in this paper to calculate the cool-down process of the cryopump, the effect of the first array structure was also taken into account. Some important results with typical parameters are: The temperature difference of the first array of the cryopump is greatly affected by the working conditions, especially when facing the room temperature vacuum system, the main heat load is concentrated on the baffle; A variable thickness bottom plate can be used to reduce the overall temperature change of the cryopump; The setting of the thermal rods is very useful to reduce the temperature change of the cryopump; The setting of the thermal rods is preferably close to the center of the baffle; If the variable property was not considered, the deviation of the cool-down time is about 24%.
Sliding Mode Control Algorithm for Regenerative Braking of an Electric Bus with a Pneumatic Anti-lock Braking System
Authors: Zhao Yiming , Zhang Junzhi , Li Chao , He Chengkun 
Published: June 2019

Abstract
Equipped with regenerative braking system, electric vehicles have the function of coordinating regenerative braking and friction braking simultaneously in normal braking situations. However, the usual operation is withdrawing the regenerative braking when the anti-lock braking system (ABS) is triggered. In order to make full use of regenerative braking, this article focuses on the cooperative control between the regenerative braking and the pneumatic friction braking during emergency stops. A sliding mode control (SMC) algorithm for regenerative braking is proposed to control the electric motor and help improve the braking performance and braking comfort. The proposed control algorithm is validated in the MATLAB/Simulink environment. A maximum mean deceleration of 25.3% is achieved and the stopping distance is shortened by 13.2m comparing to the pure pneumatic ABS on the wet gravel road, which verifies the feasibility and effectiveness of the developed control algorithm greatly.
vulcanSpot: a tool to prioritize therapeutic vulnerabilities in cancer
Authors: Perales-Patón Javier , Di Domenico Tomás , Fustero-Torre Coral , Piñeiro-Yáñez Elena , Carretero-Puche Carlos , Tejero Héctor , Valencia Alfonso , Gómez-López Gonzalo , Al-Shahrour Fátima 
Published: June 2019

Abstract

Motivation
Genetic alterations lead to tumor progression and cell survival but also uncover cancer-specific vulnerabilities on gene dependencies that can be therapeutically exploited.

Results
vulcanSpot is a novel computational approach implemented to expand the therapeutic options in cancer beyond known-driver genes unlocking alternative ways to target undruggable genes. The method integrates genome-wide information provided by massive screening experiments to detect genetic vulnerabilities associated to tumors. Then, vulcanSpot prioritizes drugs to target cancer-specific gene dependencies using a weighted scoring system based on well known drug-gene relationships and drug repositioning strategies.

Availability and implementation
http://www.vulcanspot.org.

Supplementary information
Supplementary data are available at Bioinformatics online.
Impaired reward-related learning signals in remitted unmedicated patients with recurrent depression
Authors: Geugies Hanneke , Mocking Roel J T , Figueroa Caroline A , Groot Paul F C , Marsman Jan-Bernard C , Servaas Michelle N , Steele J Douglas , Schene Aart H , Ruhé Henricus G 
Published: June 2019

Abstract
One of the core symptoms of major depressive disorder is anhedonia, an inability to experience pleasure. In patients with major depressive disorder, a dysfunctional reward-system may exist, with blunted temporal difference reward-related learning signals in the ventral striatum and increased temporal difference-related (dopaminergic) activation in the ventral tegmental area. Anhedonia often remains as residual symptom during remission; however, it remains largely unknown whether the abovementioned reward systems are still dysfunctional when patients are in remission. We used a Pavlovian classical conditioning functional MRI task to explore the relationship between anhedonia and the temporal difference-related response of the ventral tegmental area and ventral striatum in medication-free remitted recurrent depression patients (n = 36) versus healthy control subjects (n = 27). Computational modelling was used to obtain the expected temporal difference errors during this task. Patients, compared to healthy controls, showed significantly increased temporal difference reward learning activation in the ventral tegmental area (PFWE,SVC = 0.028). No differences were observed between groups for ventral striatum activity. A group × anhedonia interaction [t(57) = −2.29, P = 0.026] indicated that in patients, higher anhedonia was associated with lower temporal difference activation in the ventral tegmental area, while in healthy controls higher anhedonia was associated with higher ventral tegmental area activation. These findings suggest impaired reward-related learning signals in the ventral tegmental area during remission in patients with depression. This merits further investigation to identify impaired reward-related learning as an endophenotype for recurrent depression. Moreover, the inverse association between reinforcement learning and anhedonia in patients implies an additional disturbing influence of anhedonia on reward-related learning or vice versa, suggesting that the level of anhedonia should be considered in behavioural treatments.
The secreted matrix protein mindin increases prostate tumor progression and tumor-bone crosstalk via ERK 1/2 regulation
Authors: Ardura Juan A , Gutiérrez-Rojas Irene , Álvarez-Carrión Luis , Rodríguez-Ramos M Rosario , Pozuelo José M , Alonso Verónica 
Published: June 2019

AbstractAdvanced prostate cancer cells preferentially metastasize to bone by acquiring a bone phenotype that allows metastatic cells to thrive in the skeletal environment. Identification of factors that promote the expression of ectopic bone genes—process known as osteomimicry—leading to tumor progression is crucial to prevent and treat metastatic prostate cancer and prolong life expectancy for patients. Here, we identify the extracelular matrix protein mindin in the secretome of prostate adenocarcinoma cells and show that mindin overexpression in human and mouse TRAMP-C1-induced prostate tumors correlates with upregulated levels of bone-related genes in the tumorigenic prostate tissues. Moreover, mindin silencing decreased osteomimicry in adenocarcinoma cells and in the prostate tumor mice model, as well as reduced tumor cell proliferation, migration and adhesion to bone cells. Inhibition of the extracellular signal-regulated kinase 1/2 (ERK 1/2) phosphorylation decreased the proliferative, migratory and pro-adhesion actions of mindin on prostate tumor cells. In addition, conditioned media obtained by crosstalk stimulation of either osteocytes or osteoblasts with the secretome of TRAMP-C1 cells promoted osteomimicry in prostate tumor cells; an effect inhibited by mindin silencing of TRAMP-C1 cells. In vivo, tibiae of primary tumor-bearing mice overexpressed the pro-angiogenic and pro-metastattic factor vascular endothelial growth factor receptor 2 (VEGFR2) in a mindin-dependent manner. Our findings indicate that mindin is a novel regulator of osteomimicry in prostate tumors and potentially mediates tumor-bone cell crosstalk, suggesting its promising role as a target to inhibit bone metastases.
Sex hormone-binding globulin suppresses NAFLD-triggered hepatocarcinogenesis after menopause
Authors: Lee Sang R , Lee Young Ho , Yang Hyun , Lee Hye Won , Lee Geun-Shik , An Beum-Soo , Jeung Eui-Bae , Park Bae-Keun , Hong Eui-Ju 
Published: June 2019

Abstract
It is generally accepted that androgen receptors increase the risk of hepatocellular carcinoma (HCC), and that estrogen reduces risk of HCC. Many studies regarding this have involved males. We, therefore, have focused our attention on females, especially postmenopausal females, who typically have limited supplies of estrogen. By using sex hormone-binding globulin (SHBG) transgenic mice, we produced a humanoid environment, and facilitated deposition and modulation of sex hormones. After exposure to diethylnitrosamine to induce HCC and upon reaching the age of 40 weeks, mice were fed the fat-rich diet for 5 months. Fat-rich diet fed or ovariectomized (OVX) wild-type mice aged 62 weeks showed HCC progression, whereas fat-rich diet fed SHBG mice or OVX SHBG mice displayed fewer tumors. In the liver of fat-rich diet fed SHBG mice, estrogenic conditions including high levels of 17β-estradiol and estrogen receptor alpha led to the induction of the lipogenesis inhibitor, phosphorylated acetyl-CoA carboxylase, and consequently suppressed fatty liver. The presence of plasma SHBG in HCC bearing mice suppressed the levels of steatosis and inflammation in a process mediated by estrogens and estrogen receptor alpha. Conversely, in the liver of OVX SHBG mice, lipogenic inhibition was also observed under conditions where the supply of estrogens is limited. Through in vitro experiment, it was confirmed SHBG suppresses lipogenesis via inhibition of acetyl-CoA carboxylase level. In conclusion, our results show that plasma SHBG might have a clinical impact on lipid-mediated hepatic diseases.
Together stronger: boundary work within an Australian systems-based prevention initiative
Authors: Roussy Véronique , Riley Therese , Livingstone Charles 
Published: June 2019

Abstract
Complexity and systems science are increasingly used to devise interventions to address health and social problems. Boundaries are important in systems thinking, as they bring attention to the power dynamics that guide decision-making around the framing of a situation, and how it is subsequently tackled. Using complexity theory as an analytical frame, this qualitative exploratory study examined boundary interactions between local government and community health organizations during the operationalization of a systems-based initiative to prevent obesity and chronic diseases (Healthy Together Communities—HTCs) in Victoria, Australia. Across two HTC sites, data was generated through semi-structured interviews with 20 key informants, in mid-2015. Template analysis based on properties of complex systems was applied to the data. The dynamics of boundary work are explored using three case illustrations: alignment, boundary spanning and boundary permeability. Alignment was both a process and an outcome of boundary work, and occurred at strategic, operational and individual levels. Boundary spanning was an important mechanism to develop a unified collaborative approach, and ensure that mainstream initiatives reached disadvantaged groups. Finally, some boundaries exhibited different levels of permeability for local government and community health organizations. This influenced how each organization could contribute to HTC interventions in unique, yet complementary ways. The study of boundary work offers potential for understanding the mechanisms that contribute to the nonlinear behaviour of complex systems. The complementarity of partnering organizations, and boundary dynamics should be considered when designing and operationalizing multilevel, complex systems-informed prevention initiatives.
Worldwide decline of IVF birth rates and its probable causes
Authors: Gleicher N , Kushnir V A , Barad D H 
Published: June 2019

Abstract
With steadily improving pregnancy and live birth rates, IVF over approximately the first two and a half decades evolved into a highly successful treatment for female and male infertility, reaching peak live birth rates by 2001–2002. Plateauing rates, thereafter, actually started declining in most regions of the world. We here report worldwide IVF live birth rates between 2004 and 2016, defined as live births per fresh IVF/ICSI cycle started, and how the introduction of certain practice add-ons in timing was associated with changes in these live birth rates. We also attempted to define how rapid worldwide ‘industrialization’ (transition from a private practice model to an investor-driven industry) and ‘commoditization’ in IVF practice (primary competitive emphasis on revenue rather than IVF outcomes) affected IVF outcomes. The data presented here are based on published regional registry data from governments and/or specialty societies, covering the USA, Canada, the UK, Australia/New Zealand (combined), Latin America (as a block) and Japan. Changes in live birth rates were associated with introduction of new IVF practices, including mild stimulation, elective single embryo transfer (eSET), PGS (now renamed preimplantation genetic testing for aneuploidy), all-freeze cycles and embryo banking. Profound negative associations were observed with mild stimulation, extended embryo culture to blastocyst and eSET in Japan, Australia/New Zealand and Canada but to milder degrees also elsewhere. Effects of ‘industrialization’ suggested rising utilization of add-ons (‘commoditization’), increased IVF costs, reduced live birth rates and poorer patient satisfaction. Over the past decade and a half, IVF, therefore, has increasingly disappointed outcome expectations. Remarkably, neither the profession nor the public have paid attention to this development which, therefore, also has gone unexplained. It now urgently calls for evidence-based explanations.
Enforcing constitutional conventions
Authors: Ahmed Farrah , Albert Richard , Perry Adam 
Published: June 2019

Abstract
In an earlier article, we disproved the three claims central to the dominant view in the study of constitutional conventions: that there is a shared “Commonwealth approach” to constitutional conventions; that Commonwealth courts will recognize and employ conventions but never enforce them; and that conventions are sharply distinguishable from rules of law. We drew from Canada, India, and the United Kingdom to demonstrate that Commonwealth courts have recognized, employed, and indeed also enforced conventions. In this article, we turn from the descriptive to the normative, arguing, again in contrast with the dominant view, that Commonwealth courts sometimes should enforce conventions. We argue that courts should act as executors of the will and judgment of constitutional actors, and limit themselves to enforcing only power-shifting conventions: conventions which transfer power from those who have legal power to those who can legitimately wield it. In playing this role, judges uphold the legitimate allocation of power—legitimate, not according to judges but according to constitutional actors themselves.
Poly-ℤ Group Actions on Kirchberg Algebras I
Authors: Izumi Masaki , Matui Hiroki 
Published: June 2019

AbstractToward the complete classification of poly-${\mathbb{Z}}$ group actions on Kirchberg algebras, we prove several fundamental theorems that are used in the classification. In addition, as an application of them, we classify outer actions of poly-${\mathbb{Z}}$ groups of Hirsch length not greater than three on unital Kirchberg algebras up to $KK$-trivial cocycle conjugacy.
Test collections for electronic health record-based clinical information retrieval
Authors: Wang Yanshan , Wen Andrew , Liu Sijia , Hersh William , Bedrick Steven , Liu Hongfang 
Published: June 2019

AbstractObjectivesTo create test collections for evaluating clinical information retrieval (IR) systems and advancing clinical IR research.Materials and MethodsElectronic health record (EHR) data, including structured and free-text data, from 45 000 patients who are a part of the Mayo Clinic Biobank cohort was retrieved from the clinical data warehouse. The clinical IR system indexed a total of 42 million free-text EHR documents. The search queries consisted of 56 topics developed through a collaboration between Mayo Clinic and Oregon Health & Science University. We described the creation of test collections, including a to-be-evaluated document pool using five retrieval models, and human assessment guidelines. We analyzed the relevance judgment results in terms of human agreement and time spent, and results of three levels of relevance, and reported performance of five retrieval models.ResultsThe two judges had a moderate overall agreement with a Kappa value of 0.49, spent a consistent amount of time judging the relevance, and were able to identify easy and difficult topics. The conventional retrieval model performed best on most topics while a concept-based retrieval model had better performance on the topics requiring conceptual level retrieval.DiscussionIR can provide an alternate approach to leveraging clinical narratives for patient information discovery as it is less dependent on semantics. Our study showed the feasibility of test collections along with a few challenges.ConclusionThe conventional test collections for evaluating the IR system show potential for successfully evaluating clinical IR systems with a few challenges to be investigated.