bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance and Return to Sport After Hip Arthroscopic Surgery in Major League Baseball Players
Authors: Jack Robert A. , Sochacki Kyle R. , Hirase Takashi , Vickery Justin , McCulloch Patrick C. , Lintner David M. , Harris Joshua D. 
Published: February 2019

Background: Femoroacetabular impingement (FAI) is a common cause of hip pain that may lead to decreased performance in Major League Baseball (MLB) players. Purpose: To determine the (1) return-to-sport (RTS) rate in MLB players after hip arthroscopic surgery for FAI; (2) postoperative career length, innings pitched (IP) (pitchers), and plate appearances (PA) (position players); (3) preoperative and postoperative performance; and (4) postoperative performance compared with control players matched by position, age, years of experience, and performance. Study Design: Cohort study; Level of evidence, 3. Methods: MLB athletes who underwent hip arthroscopic surgery for FAI and matched controls were identified. Demographic and performance data were collected. RTS was defined as playing in at least 1 MLB game after surgery. Continuous variables of each group were compared using a 2-tailed paired-samples Student t test for normally distributed data. The chi-square test was used to analyze categorical data. The Bonferroni correction was used to control for multiple comparisons, with statistical significance defined by a P value of ≤.007. Results: A total of 50 players (57 surgeries) were analyzed (mean age, 30.4 ± 3.9 years; mean MLB experience at the time of surgery, 7.0 ± 4.6 years). Pitchers (31 surgeries; 54.4%) represented the largest proportion of players analyzed. Of these players, 42 (47 surgeries; 82.5%) were able to RTS at a mean of 8.3 ± 4.1 months. The overall 1-year MLB career survival rate of players undergoing FAI surgery was 78.9%. Players in the control group were in MLB a similar number of years (4.0 ± 2.9 years) to players who underwent surgery (3.3 ± 2.4 years) ( P > .007). There was no significant decrease in IP or PA per season after surgery ( P > .007). There was no significant difference in performance for pitchers and nonpitchers compared with matched controls after surgery ( P > .007). Conclusion: The RTS rate for MLB athletes after hip arthroscopic surgery for FAI was high. There were similar IP, PA, and career lengths postoperatively compared with preoperatively and with matched controls. There was no significant difference in performance for pitchers and nonpitchers compared with matched controls after surgery.
Assessing Performance in Health Care Using International Surveys: Are Patient and Clinician Perspectives Complementary or Substitutive
Authors: Levesque Jean-Frederic , Corscadden Lisa , Dave Anushree , Sutherland Kim 
Published: February 2019

Background: Over the last decade, international surveys of patients and clinicians have been used to compare health care across countries. Findings from these surveys have been extensively used to create aggregate scores and rankings. Objective: To assess the concordance of survey responses provided by patients and clinicians. Methods: Analysis of 16 pairs of questions that focused on coordination, organizational factors, and patient-centered competencies from the Commonwealth Fund International Health Policy Survey of older adults (2014) and of primary care physicians (2015). Concordance was assessed by comparing absolute rates and relative rankings. Results: In absolute terms, patients and clinicians gave differing responses for questions about coordination of care (patients were more positive) and provision of after-hours care (patients were less positive). In relative terms, country rankings were positively correlated for 5 of 16 question pairs (Spearman ρ > .6 and P < .05). Conclusion: Patterns of concordance between patient and clinician perspectives provides information to guide the use of survey data in performance assessment. However, this study highlights the need to assess the complementarity and substitutive nature of patients’ and clinicians’ perspectives before combining them to create aggregate assessments of performance.
Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia
Authors: Sánchez-Martínez Diego , Baroni Matteo L. , Gutierrez-Agüera Francisco , Roca-Ho Heleia , Blanch-Lombarte Oscar , González-García Sara , Torrebadell Montserrat , Junca Jordi , Ramírez-Orellana Manuel , Velasco-Hernández Talía , Bueno Clara , Fuster José Luís , Prado Julia G. , Calvo Julien , Uzan Benjamin , Cools Jan , Camos Mireia , Pflumio Françoise , Toribio María Luisa , Menéndez Pablo 
Published: February 2019

AbstractRelapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen receptor (CAR) T cells (CARTs) to T-ALL remains challenging because the shared expression of target antigens between CARTs and T-ALL blasts leads to CART fratricide. CD1a is exclusively expressed in cortical T-ALL (coT-ALL), a major subset of T-ALL, and retained at relapse. This article reports that the expression of CD1a is mainly restricted to developing cortical thymocytes, and neither CD34+ progenitors nor T cells express CD1a during ontogeny, confining the risk of on-target/off-tumor toxicity. We thus developed and preclinically validated a CD1a-specific CAR with robust and specific cytotoxicity in vitro and antileukemic activity in vivo in xenograft models of coT-ALL, using both cell lines and coT-ALL patient–derived primary blasts. CD1a-CARTs are fratricide resistant, persist long term in vivo (retaining antileukemic activity in re-challenge experiments), and respond to viral antigens. Our data support the therapeutic and safe use of fratricide-resistant CD1a-CARTs for relapsed/refractory coT-ALL.
Untapped potential of multicenter studies: a review of cardiovascular risk prediction models revealed inappropriate analyses and wide variation in reporting
Authors: Wynants L. , Kent D. M. , Timmerman D. , Lundquist C. M. , Van Calster B. 
Published: February 2019

Abstract
Background
Clinical prediction models are often constructed using multicenter databases. Such a data structure poses additional challenges for statistical analysis (clustered data) but offers opportunities for model generalizability to a broad range of centers. The purpose of this study was to describe properties, analysis, and reporting of multicenter studies in the Tufts PACE Clinical Prediction Model Registry and to illustrate consequences of common design and analyses choices.

Methods
Fifty randomly selected studies that are included in the Tufts registry as multicenter and published after 2000 underwent full-text screening. Simulated examples illustrate some key concepts relevant to multicenter prediction research.

Results
Multicenter studies differed widely in the number of participating centers (range 2 to 5473). Thirty-nine of 50 studies ignored the multicenter nature of data in the statistical analysis. In the others, clustering was resolved by developing the model on only one center, using mixed effects or stratified regression, or by using center-level characteristics as predictors. Twenty-three of 50 studies did not describe the clinical settings or type of centers from which data was obtained. Four of 50 studies discussed neither generalizability nor external validity of the developed model.

Conclusions
Regression methods and validation strategies tailored to multicenter studies are underutilized. Reporting on generalizability and potential external validity of the model lacks transparency. Hence, multicenter prediction research has untapped potential.

Registration
This review was not registered.
Tomographic reconstructions of borehole sections using the radio imaging method at Pyhäsalmi massive sulfide deposit in Finland
Authors: Korpisalo Arto 
Published: February 2019

We have used the radio imaging method (RIM) to delineate attenuating zones in two borehole sections in the area of the Pyhäsalmi volcanogenic massive sulfide (VMS) copper-zinc deposit located in central Finland. The frequency band (312.5–2500 kHz) is higher and thus provides better resolution and sensitivity to conductive targets than traditional ground-level and borehole electromagnetic (EM) methods. When EM waves are assumed to be propagated along straight rays, the simultaneous iterative reconstruction technique can be used and the decayed amplitudes of the electric field are converted to the attenuation coefficient in dB/m. The straight-ray assumption was, however, not met in this study. The reconstruction results of two borehole sections were compared with time-domain EM (TEM) data and electric logging data. Electric logging reveals the nearby conducive mineralizations, and when compared with RIM data, the continuation of attenuating formations can be better predicted. The intersections interpreted from the TEM data were consistent with the RIM data. However, continuation of the attenuating domains could only be established from RIM data. Low ray densities at the upper and lower edges, violation of the straight-ray assumption, and out-of-plane targets may generate artifacts. In addition, the constructions suffer from smearing in the direction of the raypath. According to the results, we can recover the shape and orientation of attenuating targets in the borehole sections, but the physical properties are underestimated due to the straight-ray assumption. The comparison studies confirmed that RIM is well-suited to estimating subsurface conductivity properties and to predicting the continuation of attenuating domains between the boreholes at the Pyhäsalmi VMS deposit.
The Shuey-Radon transform
Authors: Gholami Ali , Farshad Milad 
Published: February 2019

The traditional hyperbolic Radon transform (RT) decomposes seismic data into a sum of constant amplitude basis functions. This limits the performance of the transform when dealing with real data in which the reflection amplitudes include the amplitude variation with offset (AVO) variations. We adopted the Shuey-Radon transform as a combination of the RT and Shuey’s approximation of reflectivity to accurately model reflections including AVO effects. The new transform splits the seismic gather into three Radon panels: The first models the reflections at zero offset, and the other two panels add capability to model the AVO gradient and curvature. There are two main advantages of the Shuey-Radon transform over similar algorithms, which are based on a polynomial expansion of the AVO response. (1) It is able to model reflections more accurately. This leads to more focused coefficients in the transform domain and hence provides more accurate processing results. (2) Unlike polynomial-based approaches, the coefficients of the Shuey-Radon transform are directly connected to the classic AVO parameters (intercept, gradient, and curvature). Therefore, the resulting coefficients can further be used for interpretation purposes. The solution of the new transform is defined via an underdetermined linear system of equations. It is formulated as a sparsity-promoting optimization, and it is solved efficiently using an orthogonal matching pursuit algorithm. Applications to different numerical experiments indicate that the Shuey-Radon transform outperforms the polynomial and conventional RTs.
Axin proteolysis by Iduna is required for the regulation of stem cell proliferation and intestinal homeostasis in Drosophila
Authors: Gultekin Yetis , Steller Hermann 
Published: February 2019

ABSTRACT
Self-renewal of intestinal stem cells is controlled by Wingless/Wnt-β catenin signaling in both Drosophila and mammals. As Axin is a rate-limiting factor in Wingless signaling, its regulation is essential. Iduna is an evolutionarily conserved ubiquitin E3 ligase that has been identified as a crucial regulator for degradation of ADP-ribosylated Axin and, thus, of Wnt/β-catenin signaling. However, its physiological significance remains to be demonstrated. Here, we generated loss-of-function mutants of Iduna to investigate its physiological role in Drosophila. Genetic depletion of Iduna causes the accumulation of both Tankyrase and Axin. Increase of Axin protein in enterocytes non-autonomously enhanced stem cell divisions in the Drosophila midgut. Enterocytes secreted Unpaired proteins and thereby stimulated the activity of the JAK-STAT pathway in intestinal stem cells. A decrease in Axin gene expression suppressed the over-proliferation of stem cells and restored their numbers to normal levels in Iduna mutants. These findings suggest that Iduna-mediated regulation of Axin proteolysis is essential for tissue homeostasis in the Drosophila midgut.
From gene to treatment: supporting rare disease translational research through model systems
Authors: Hmeljak Julija , Justice Monica J. 
Published: February 2019

ABSTRACT
Individual rare diseases may affect only a few people, making them difficult to recognize, diagnose or treat by studying humans alone. Instead, model organisms help to validate genetic associations, understand functional pathways and develop therapeutic interventions for rare diseases. In this Editorial, we point to the key parameters in face, construct, predictive and target validity for accurate disease modelling, with special emphasis on rare disease models. Raising the experimental standards for disease models will enhance successful clinical translation and benefit rare disease research.
The Public Work of Identity Performance: Advocacy and Dissent in Teachers’ Open Letters
Authors: Garahan Katie L. 
Published: February 2019

AbstractIn the rhetoric of contemporary federal education reform, public school teachers are often blamed for and championed as solutions to educational problems. Representations of teachers as heroic and blameworthy are an integral component of a neoliberal rationality apparent in education reform since the publication of the Reagan administration’s A Nation at Risk, as they allow political actors to promote individual solutions to systemic issues that affect student achievement. After briefly exploring the rhetoric of reform, this essay focuses on the ways teachers negotiate the discourses that implicate their profession. To do so, I analyze a corpus of 18 open letters written and published online by current and former public school teachers in protest of policy and/or specific political actors. I argue that authors of these open letters leverage their professional identities to protest and articulate alternatives to seemingly pervasive neoliberal logics inherent in contemporary education reform. In turn, I maintain that analyzing vernacular exchanges, such as teachers’ protest discourse, is imperative to understanding the material consequences of education policy as well as the full discursive space of policymaking.
Scientist Citizens: Rhetoric and Responsibility in L’Aquila
Authors: Pietrucci Pamela , Ceccarelli Leah 
Published: February 2019

AbstractIn this essay, we analyze the public communication debacle before the 2009 L’Aquila earthquake that led to the infamous trial of the “L’Aquila Seven.” Examining the trial transcripts to extract norms regarding the proper role of scientists in society, we conclude that the first verdict interpellated the figure of the responsible scientist citizen who is expected to perform rhetorical citizenship when communicating with a lay public, while the second assumed a distinction between public and technical spheres that absolves scientists from responsibility to their fellow citizens and reduces their role to performance of an expertise divorced from rhetoric. Tracing the civic outcomes of these conflicting norms, we identify three missed opportunities during the prequake discourse in which the scientists failed to correct statements that they, and only they, knew to be flawed. To prevent future communicative debacles that arise from a dangerous separation of scientists and laypeople, we argue that scientists need to come to see themselves as scientist citizens, experts who take on the civic responsibility of clearly communicating their knowledge to their fellow citizens when such sharing is necessary to the public good.
Peran kepercayaan merek, citra merek, dan celebrity endorsement terhadap loyalitas merek bedak tabur wardah
Authors: Novitasari Anggi , Suryani Tatik 
Published: February 2019

The competition in Indonesia cosmetics industry is growing rapidly. Many brands of face powder available in the market have been popular and got a good qualityr. Wardah is one of halal cosmetics manufactured in Indonesia. This study aims to analyze the effect of brand trust, brand image, and celebrity endorsement on brand loyalty of Wardah face powder in Surabaya. Data collected with questionnaire which given to 97 respondents from community of Surabaya. The sample was selected by judgement sampling. The data were alanized by using MRA (Multiple Regression Analysis). The results found that brand trust has significant effect on brand loyalty. Brand image has no significant effect on brand loyalty and celebrity endorsement has no significant effect on brand loyalty. The results show that brand trust, brand image and celebrity endorsement effect significantly on brand loyalty. The implication is to improve the brand trust by holding event beauty class for consumert to get more trust in the facial powderof Wardah, and to increase the service for the consumers and adjust the price for them.
Belief Adjustment Model Test in Investment Decision Making: Experimentation of short information Series
Authors: Nisa Aulida Kholifatun 
Published: February 2019

The aims of this study are examine the difference judgement given by investor using belief adjustment model to consider the pattern of presentation, the order of information and the tpye of information. This study using experimental design 2x2x2 mixed design, include: the pattern of presentation (Step by Step and End of Sequence), the order of information good news followed by bad news (++--) and bad news followed by good news (--++), andÂ the type of information (accounting and non accounting). The hypothesis in this study were testedÂ with Independence Sample T-test and Mann Whitney U. The participants were students STIE Perbanas Surabaya bachelor degree majoring in Accounting and Management who have knowlegde related to investment management and capital market or investment portfolio management and financial statements analysis. The result of this study showed that occurs recency effect while the pattern of information of Step by Step (SbS) and the type of information accounting and non accounting. This also occurs while the pattern of presentation of End of Sequence (EoS) and the type of acounting information occurs recency effect, wheares there was no order effect on the type of non accounting information.
The Testing of Belief-Adjustment Model and Framing Effect on Non-Professional Investorâ€™s Investment Decision-Making
Authors: Hanafi Taufan 
Published: February 2019

This study aims to find out the effect of belief-adjustment model and framing effect on non-professional investorâ€™s investment decision making. The designs of experiment used in Â this study are the presentation pattern of 2x2x2, disclosure pattern (step-by-step and end-of-sequence), disclosure evidence of information order (good news followed by bad news and Â bad news followed by good news), and framing effect (framing condition according to the information and framing condition with the reversed information). The research hypotheses in this study are tested using parametric test. The dependent variable used in this study is investment decision making, while, the independent variables used in this study are belief-adjustment model and framing effect. The number of participants involved in this study is 80 undergraduate students of STIE Perbanas Surabaya majoring in Accounting or Management. The results indicate that there are significant differences in decision making and recency effect occurs between the investors who receive good news followed by bad news and the investors who receive bad news followed by good news in the step-by-step disclosure pattern with framing condition according to the information. The results of this study also show that primacy effect occurs between the investors who receive good news followed by bad news and the investors who receive bad news followed by good news in the step-by-step disclosure pattern with framing condition in reversed information.
The Influence of Foaming Agent and Cake Thickness on the Drying Process Tomatoes Using a Tray Dryer
Authors: Hariyadi Tri , Santoso Herry , Retti Witono Judy 
Published: February 2019

Moisture content of tomato (Licopersicon esculentum Mill.) is very high, so easily damaged due to physical impact, enzyme and microbes activity. Further processing is necessary in order to improve shelf life, one way is drying method. This work studied the effect of foaming agent and cake thickness in tomato drying using tray dryer at various temperatures. Foaming agent is used to convert the material into foam, so that the drying temperature can be set relatively low to preserves color, aroma and nutrient composition of the material. The tray dryer is used, because it is simple and the operation cost is relatively cheap. In this work, tomatoes were sliced, crushed for 10 minutes using blender, separated from the seeds and residues with a 60 mesh sieve, and then mixed with dextrin and foaming agent Tween 80 each by 5% weight respectively. Each mixture was blended for 10 minutes. The tray dryer was filled with hot air at 2.0 m/sec with temperature variation of 40, 50, 60 and 70ºC and cake thickness variation of 2 and 4 mm. The results obtained, drying at 50° C is faster than 40º C, while 50 to 70º C is relatively the same. The thicker the cake, the slower the drying time. Performance of foaming agent Tween 80 compared to chemical foaming agent is a natural egg white powder. Drying with a foaming agent Tween 80 faster than egg white powder. Keywords: cake thickness; foaming agent; tomato; tray dryer
Hydrogen Sulfide Removal from Biogas Using Digester Effluent Absorbent in a Continuous Vertical Column
Authors: Pranolo Sunu Herwi , Paryanto Paryanto , Margono Margono , Rizaldy Bachtiar , Yansah Hendrix 
Published: February 2019

HYDROGEN SULFIDE REMOVAL FROM BIOGAS USING DIGESTER EFFLUENT ABSORBENT IN A CONTINUOUS VERTICAL COLUMN. Gas-Liquid mass transfer is one of the most commonly used phenomena in the chemical process, such as absorbtion. This research evaluates the value of liquid phase mass transfer coefficient of hydrogen sulfide removal from biogas in a continous contactor column for digester effluent-biogas system. This study was carried out by contacting biogas at certain flow with digester effluent continously in a counter-current flow packed bed column. Samples were taken in steady state condition. This research used raschig rings, large balls, and small balls as packing materials with surface areas are 0.9269 m2/m3, 0.6279 m2/m3, and 0.2992 m2/m3 respectively at volumetric flow rates of biogas from 0.1109 m3/h to 0.8846 m3/h. The results show that the relationship between the variables and mass transfer coefficient gives following mathematical model This model is valid in the range of (As·dt) and (Vg/dt·DL) respectively from 0.03 to 0.09 and from 237,267.08 to 3,307,522.67. Average error is 17.85%.