bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective Assessment of Safety, Tolerance, and Perceptions of Awake Airway and Esophageal Dilation
Authors: Young VyVy N. , Gillard Danielle M. , Truong Brandon , Lappin James J. , Perrin Claire E. , Stockton Steven D. , Rosen Clark A. , Ma Yue 
Published: November 2024

ObjectiveAn increasing number of laryngeal and esophageal procedures are being performed as “awake” procedures (non‐general anesthesia), with some under local anesthesia, including in clinic. While high tolerance and safety profiles have been reported for various laryngeal procedures, few studies directly assess tolerability of awake dilation procedures of the upper esophagus (UE) and laryngotracheal airway (LTA).Study DesignProspective, open‐label.MethodsProspectively collected patient and physician surveys from a tertiary laryngology center recorded patient tolerance, safety, and perceptions of awake UE and LTA balloon dilation.ResultsFifty‐six awake procedures were performed on 41 patients, including 46 UE and 20 LTA dilations. All procedures were successfully completed. Overall pain was mild (3.5 ± 2.4/10, ranging 0 = no pain to10 = worst pain) and the dilation itself was reportedly the most painful portion (4.1 ± 2.9/10). Patient satisfaction with the procedure was high (7.0 ± 2.2/10, ranging 0 = worst to 10 = best experience). Most patients would undergo the procedure again (73.6%) and would recommend the procedure to others (89.3%). Patient‐reported tolerance was similar immediately postoperatively and at follow‐up. LTA and UE dilation patients reported similar levels of tolerance.ConclusionsAwake upper esophageal balloon dilation is a safe, well‐tolerated procedure with high completion and patient satisfaction rates. Similarly, early experience with awake laryngotracheal airway balloon dilation suggests comparable favorability, although careful consideration of patient selection and procedural implementation is strongly recommended to optimize and protect patient safety.Level of Evidence3 Laryngoscope, 2024
Signaling the Capability of New Counterterrorism Technologies in the Face of a Strategic Threat
Authors: Tokel Yusuf Ihsan , Hunt Kyle , Zhuang Jun 
Published: November 2024

ABSTRACTWhen implementing new security technologies (e.g., cargo scanners at ports), security and defense agencies face important decisions regarding the disclosure of related information to the public. Public disclosure of these technologies can grant adversarial organizations access to critical security‐related information, enabling them to potentially develop or adjust their attack strategies to circumvent defense systems. Alternatively, withholding information about newly deployed technologies can create uncertainties for adversaries regarding the effectiveness of defense systems. In this work, we study defensive information disclosure related to the deployment of new security technology, focusing on the level of technical information released by the defender and how this affects the adversary's (i) belief about the technology's capability (in detecting or otherwise thwarting an attack) and (ii) attack plan. Specifically, we introduce a novel signaling model in which the defender has private information about the (level of) capability of her technology, and decides on the level of related technical detail to be disclosed. The attacker, upon receiving the defender's signal, updates his belief about the capability of the technology and subsequently decides whether to launch an attack. We obtain and prove closed‐form equilibrium solutions to the model and conduct numerical sensitivity analyses to understand how the equilibrium strategies change as the model's data varies. Based on the equilibrium conditions, we also characterize and analyze four unique scenarios that partition the solution space based on relations between the defender's signaling costs.
Clinicopathological Analysis of a European Cohort of MYOD1 Mutant Rhabdomyosarcomas in Children and Young Adults
Authors: Chisholm Julia C. , Selfe Joanna L. , Alaggio Rita , Cheesman Edmund , Zin Angelica , Tombolan Lucia , Parafioriti Antonina , Milano Giuseppe Maria , Adams Madeleine , Popov Sergey , Česen Maja , Tafjord Svetlana , Jenney Meriel , Proszek Paula Z. , Schlecht Helene , Di Carlo Daniela , Shipley Janet , Kelsey Anna 
Published: November 2024

ABSTRACTBackgroundPatients with PAX3/7‐FOXO1 fusion‐negative rhabdomyosarcomas (fnRMS) harbouring the rare L122R MYOD1 mutation have significantly poorer prognosis than other fnRMS. We undertook a detailed clinicopathological evaluation of a cohort of patients with MYOD1 mutated fnRMS in order to improve risk stratification and treatment options.ProcedureHistological, mutational and clinical data from a cohort of patients with MYOD1 mutant RMS treated in Europe were analysed.ResultsThirty‐two cases with mutant MYOD1 RMS were identified from patients enrolled in sequential European rhabdomyosarcoma clinical trials from 1992 to 2022 (n = 22) and non‐trial cohorts (n = 10). Thirty cases had the recurrent L122R missense mutation, one case harboured a K124E mutation and one case had a truncating mutation (S63X). Increased MyoD1 and reduced MYF4 immunostaining were consistent features of MYOD1L122R‐mutated RMS. Applying the risk stratification of the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 trial, among 20 localised RMS cases that could be assigned a risk category, one was Very High Risk, 13 were High Risk and six were Standard Risk. Eight patients had distant metastases at diagnosis. Of the 25 patients with adequate clinical follow‐up data, 15/25 (60%) patients had an event at a median time of 9 months (12/15 included failure of local control) and 13/25 (52%) died of disease.ConclusionThis MYOD1 mutant cohort demonstrates increased MYOD and reduced MYF4 immunostaining, high risk of local failure and poor survival in agreement with other studies. Increased treatment intensity and improved local control should be considered for these patients.
The meaning of “should”
Authors: Hazzan Michael J. , White Nicholas , White Jarrod 
Published: November 2024

AbstractWhen implementing the performance‐based Process Safety Management (PSM) Standard (OSHA 1910.119), industry needs to comply with applicable recognized and generally accepted good engineering practices (RAGAGEP) for their facility. While this may seem like a simple task, determining what is applicable and how it affects the design, construction, inspection/testing, and operations, it can be a significant effort. This paper aims to provide guidance on interpreting the “should” versus “shall” debate, particularly how to deal with “should” provisions, why this matters, and share lessons learned from AcuTech's extensive onsite observations where the impacts of these interpretations are seen in process safety programs.
Machine learning‐based rational design for efficient discovery of allatostatin analogs as promising lead candidates for novel IGRs
Authors: Zhang Yi‐Meng , He Qi , Cui Jia‐Lin , Liu Yan , Wang Mei‐Zi , Lu Xing‐Xing , Pan Shi‐Xiang , Iqbal Chandni , Ye De‐Xing , Sun Wen‐Yu , Zhang Xin‐Yuan , Kai Zhen‐Peng , Zhang Li , Yang Xin‐Ling 
Published: November 2024

AbstractBACKGROUNDInsect neuropeptide allatostatins (ASTs) play a vital role in regulating insect growth, development, and reproduction, making them potential candidates for new insect growth regulators (IGRs). However, the practical use of natural ASTs in pest management is constrained by their long sequences and high production costs, thus the development of AST analogs with shorter sequences and reduced cost is essential. Traditional methods for designing AST analogs are often time‐consuming and resource‐intensive. This study aims to employ new computational methodologies to understand the structure–activity relationship and efficiently discover potent AST analogs.RESULTSTwo machine learning models, utilizing multiple linear regression and support vector machine, were constructed to reveal the key structural factors that influence the juvenile hormone‐inhibiting activity of AST analogs. These models suggested that a potent AST analog should contain styrene, hydrophilic, and aromatic groups, and rotatable bonds at positions 1, 2, 3, and 4, respectively. Six analogs (A52‐A57) were designed and synthesized, and they exhibited potent juvenile hormone‐inhibiting activity (IC50 < 16 nM). Notably, analog A53 showed the best activity (IC50 = 2.07 nM), surpassing that of most natural Dippu‐ASTs, making it a potential lead candidate for IGRs.CONCLUSIONThese models promote the efficient design, screening, and prioritization of new or untested AST analogs. The study clarifies how a machine learning‐based strategy facilitates the development of AST analogs as novel IGR lead candidates, offering a useful reference for pest management. © 2024 Society of Chemical Industry.
Front Cover Image
Authors: Xia Lang , Zhang Ruirui , Chen Liping , Li Longlong , Yi Tongchuan , Chen Meixiang 
Published: November 2024

The cover image is based on the article Monitoring the leaf damage by the rice leafroller with deep learning and ultra‐light UAV by Lang Xia et al., https://doi.org/10.1002/ps.8401.
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Environmental quality in Africa and infrastructure development: The mediating impact of the knowledge economy
Authors: Kouladoum Jean‐Claude Mousseuknadji , Etsiba Sylvaniste , Monglengar Nandingar Serge , Hakizimana Jacques 
Published: November 2024

AbstractThe study investigates the impact of infrastructure development on environmental quality and the mediating impact of the knowledge economy in 48 African economies from 2000 to 2020. The Generalized Method of Moment is adopted to control for error term‐related problems and potential endogeneity through an instrumentation process. The following findings are established: First, Infrastructure development enhances environmental sustainability in Africa, through the reduction of greenhouse gasses. Second, it contributes to reducing CO2 emissions in liquid, solid and gaseous states of fuel consumption. These results hold after considering the infrastructure development indicators of the African Development Bank. Third, the findings further reveal that the transport, energy, water supply, and technology sectors all contribute to enhancing environmental quality. Fourth, taking into account differences in factor endowment, the findings indicate that infrastructure development helps reduce CO2 emissions in both lowly and highly endowed African countries, except for electricity and water supply in the lowly endowed economies, indicating that the development in these sectors needed to be speeded‐up to enhance environmental quality in these countries. Fifth, the findings indicate that the knowledge economy mediates with infrastructure development to promote environmental quality through the reduction CO2 emissions. The findings recommend policymakers promote infrastructure development for environmental efficiency in Africa. This is particularly enhanced through the mediation impact of the knowledge economy.
Atomically Resolved Surface Reconstruction of WO3 (002)
Authors: Cao Jianyu , Xia Jing , Li Xuanze , Li Yuye , Tian Lifeng , Liu Chang , Zhang Zhongshi , Cai Suijiang , Meng Xiangmin 
Published: November 2024

AbstractThe rearrangement of surface atoms in oxide nanocrystals, namely surface reconstruction, plays an important role in improving the physical and chemical properties of metal oxides. However, structural information pertaining to reconstructed surfaces is scarce due to the challenges associated with directly imaging surface and sub‐surface atoms under reconstruction conditions. Herein, the reconstruction of the nanocrystalline tungsten trioxide (002) surface is directly investigated via scanning transmission electron microscope (STEM). The results reveal that the atoms on the reconstructed WO3 (002) surface are rearranged into a (1 × 2) structure, and the structural model is determined by density functional theory (DFT) calculation. In addition, after surface reconstruction, the Fermi level shifted toward the conduction band compared to the initial surface, achieving an effect similar to n‐type doping. Surprisingly, analogous atomic rearrangements are also observed in cracks, indicating that sub‐nanometer fractures in tungsten trioxide can be remedied through surface reconstruction, thus proposing an unconventional mechanism for crack healing. Furthermore, DFT calculations are used to analyze the models and electronic properties of the reconstruction structures. These findings provide insights into the surface reconstruction of WO3 (002) and the healing of nanoscale cracks in tungsten trioxide.
Graphite‐Based Bio‐Mimetic Nanopores for Protein Sequencing and Beyond
Authors: Das Chandan K. , Fyta Maria 
Published: November 2024

AbstractProtein sequencing using nanopores represents the next frontier in bio‐analytics. However, linearizing unfolded proteins and controlling their translocation speed through solid‐state nanopores pose significant challenges in protein sequencing. In order to address these issues, this work proposes a biomimetic graphite‐based nanopore construction. These nanopores feature a nanometer‐sized pore with a constriction zone, mimicking the structure of the α‐hemolysin protein pore. Our all‐atom Molecular Dynamics simulations demonstrate the high practical potential of these nanopores by revealing how their charge state renders them complete ion‐selective and generates an electro‐osmotic flow. This study shows that this nanopore construction can detect peptides at the single amino acid level by analyzing the ionic current traces generated as peptides traverse the nanopore. The novelty of the proposed nanopore lies in its ability to modulate the hydrodynamic drag induced by electro‐osmotic flow, relative to the electro‐phoretic force. This investigation reveals that tuning these forces helps to linearize translocating peptides and extend the residence time of individual amino acids at the constriction zone of the pore. This significantly enhances the detection and sequencing efficiency of the pore. Furthermore, the high relevance of the proposed nanopores is underscored for seawater desalination through electrodialysis and extends to ion separation under salinity gradients.
Caesium‐Iodide‐Assisted Synthesis of High‐Quality, Stable, and Robust Lead‐Free Perovskite Quantum Dots
Authors: Li Shiang , Li Yuhao , Qin Minchao , Xu Luhang , Fu Yuang , Chan Pok Fung , Lu Xinhui 
Published: November 2024

AbstractThe poor morphology, and susceptibility to oxidation of tin‐based perovskite quantum dots (TQDs) have posed significant challenges, limiting their application potential. This study presents a straightforward method for synthesizing high‐quality CsSnI3‐based perovskite quantum dots (TQDs) by incorporating a mixed Cs source of Cs2CO3 and CsI. The addition of CsI increased the I:Sn ratio while maintaining Sn:Cs, resulting in TQDs with smaller size and improved uniformity. X‐ray photoelectron spectroscopy (XPS), and Nuclear magnetic resonance (NMR) analyses confirmed enhanced crystallinity, photoluminescence intensity, and antioxidation ability of CsI‐TQDs. Remarkably, these TQDs exhibit exceptional stability, enduring over 1 h in air and more than 24 h before complete oxidation, surpassing the previously reported longest lifetime in air for TQDs with conventional oleic acid (OA) and oleylamine (OAm) ligands. Furthermore, these TQD films retain robustness after ligand exchange with methyl acetate (MeOAc) and formamidinium iodide (FAI), representing the first successful short‐ligand exchange of TQDs and enabling further electronic device applications. These findings suggest that CsI in the Cs source plays a crucial role in facilitating the formation of surface complexes, regulating TQD growth and suppressing iodine vacancies.
Examining English Learners' Opportunity to Learn from High School to Community College: A Qualitative Case Study
Authors: Li Kuang , Kanno Yasuko 
Published: November 2024

AbstractStudents classified as English learners (ELs) in high school are more likely to start their postsecondary education in community colleges (CCs). Many high school EL graduates enter a CC, hoping to make good academic progress and later transfer to a 4‐year college. However, past research has found that such students often struggle in CCs and rarely earn a postsecondary credential or transfer to a 4‐year college. ELs' high school academic preparation and their subsequent college access—or lack thereof—are closely related. Yet, there is little research connecting ELs' academic preparation in high school and their subsequent ongoing trajectories once they are enrolled in CC. Drawing on the concepts of opportunity to learn (OTL) and opportunity sequences, this qualitative case study examines six high school ELs' academic trajectories from high school through CC. Our analysis shows a negative opportunity sequence in which ELs' limited OTL in high school lands them in remedial education at a local CC, which in turn delays their exposure to disciplinary courses in their majors. The students' struggles with their first disciplinary courses subsequently hinder their CC persistence and timely transfer to a 4‐year college, forcing them to reset their postsecondary goals.
Positive Correlation Between Fecal Estrogen and Glucocorticoid Metabolites in a Female Clouded Leopard
Authors: Shipp Laura E. , Boisseau Nicole P. , Kozlowski Corinne P. , Shipp Dustin W. , Franklin Ashley D. , Fazio Jilian M. , Brown Janine L. 
Published: November 2024

ABSTRACTClouded leopards are notoriously difficult to manage under human care due to their tendency toward high stress, intersex aggression, and limited reproductive success. This case study investigated the endocrinological interplay between adrenal and ovarian steroids and describes a positive correlation between concentrations of fecal estrogen and glucocorticoid metabolites in a female clouded leopard. The female was monitored through two sampling periods approximately 16 months apart, and each data set yielded similar results using a simple linear regression model. The finding of a significant positive correlation between the two steroids represents a novel finding in felids and a hitherto unidentified potential interplay between adrenal and ovarian steroid activity. It also adds to our collective understanding of the effects of estrus on female clouded leopards, impacting conservation efforts as we encourage reproduction in this vulnerable species.
A Brief Review of Bibliometric Analysis Use in Marketing Studies
Authors: Terán-Yépez Eduardo , Sánchez-Pérez Manuel , Segovia-López Cristina , Marín-Carrillo María Belén 
Published: November 2024

AbstractThis study investigates the adoption and application of bibliometric reviews in marketing literature by conducting a methodological literature review of 140 studies published in the top 47 marketing journals. Drawing on a comprehensive analysis, we explore various aspects of bibliometric review methodology, including sample size selection, database comprehensiveness, methodological complementariness, contributions to theory, and implications for practice. Our findings reveal a growing recognition and utilization of bibliometric techniques in marketing research. However, concerns persist regarding the rigor and potential contributions of bibliometric analysis. We identify key areas for improvement, such as ensuring adequate sample sizes and replicability, enhancing database comprehensiveness, employing theory-driven frameworks, and establishing implications for practice. Moreover, we provide recommendations for marketing scholars to navigate the complexities of bibliometric research effectively and make meaningful contributions to the advancement of marketing scholarship. By adhering to established guidelines and recommendations, marketing researchers can harness the power of bibliometric analysis to extract valuable insights, identify research gaps, and contribute to theoretical advancements in the discipline. This study serves as a call to action for marketing researchers to embrace bibliometric analysis as a potent tool for literature review and knowledge synthesis while also providing guidance for reviewers and editors to ensure the quality and impact of bibliometric reviews in marketing literature.
Sustainability Teaching in Marketing: An Importance-Performance Analysis in Higher Education Institutions
Authors: Martínez-Bravo María del Mar , Capobianco-Uriarte María de las Mercedes , Terán-Yépez Eduardo , Matos-Pedro Eugenia Maria Gonçalves , Barbosa-Pereira Carla Alexandra 
Published: November 2024

AbstractSustainability teaching has come to the fore as a foundation for addressing the unprecedented challenges that the planet and the society face. However, the effectiveness of higher education institutions (HEI) in their pivotal role in educating and instructing the students who will occupy leadership, management, and marketing positions in the future has been questioned. The objective of this study is to examine the performance of sustainability teaching based on an importance-performance analysis of the perceptions of marketing students in two HEI: the University of Almería and the University of Beira Interior. We analyze whether students differ in which learning approaches they consider important for integrating sustainability into their competencies, whether they consider them effective, and how their opinions differ depending on the HEI they come from. This study contributes to guiding universities in their actions to ensure that graduates are prepared to navigate the complex landscape of sustainability in their upcoming work career.
Game-Based Learning Through the Use of Artwork Images: Influence on the Perception of a Product
Authors: Galindo-Durán Alejandro , Uribe-Toril Juan , Ruiz-Real José Luis 
Published: November 2024

AbstractThis study analyzes the impact on the perception of a product by consumers, in an educational context, through the inclusion of works of art in the product design and applying active methodologies such as game-based learning (GBL). An educational intervention carried out in a secondary school is presented, trying to investigate if the incorporation of artistic elements to a product is perceived in different magnitude in relation to its value, quality, or luxury among students. In addition, an experimental group to which an activity using GBL was previously applied is shown and the results of the different answers given by the different groups of students are compared. The results suggest that the incorporation of artistic elements improves the perception of the value and quality of the product and that those students who were part of the experimental group valued the products even better, with significant differences between the two groups, in addition to enriching their educational experience. This research highlights the importance of integrating art into the educational curriculum as well as the application of active methodologies in the teaching process in order to improve both the educational experience and the learning process.