bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microfracture of subchondral bone leads to persistent subchondral sclerosis and poorer functional outcomes following distraction arthroplasty of the ankle joint while biologic augment may improve recovery times
Authors: Gianakos Arianna , Kennedy John 
Published: May 2019

Category: Ankle Arthritis Introduction/Purpose: Treatment of ankle osteoarthritis (OA) continues to remain a challenge. Previous reports have demonstrated the short-term benefits of using joint distraction for the treatment of ankle (OA), however, its efficacy in long term clinical outcomes and its role in preserving the joint space remains controversial. The purpose of this study is to establish whether microfracture or biologics improve the outcomes of ankle distraction. Methods: Records of patients that underwent an ankle distraction procedure between January 2009-December 2013 were retrospectively reviewed. Four groups were identified: Group 1: distraction with no additional treatment, Group 2: distraction with microfracture, Group 3: distraction with microfracture and BMAC/PRP, Group 4: distraction with BMAC/PRP. Demographic data was recorded. Pre-and-postoperative range of motion, Foot and Ankle Outcome Scores (FAOS), complication rate, and return to activity were evaluated. Radiographic images were used to assess the joint space changes pre-operatively and post-operatively. Global comparisons were performed using chi square testing, while individual between-group comparisons were made using robust, resistant regression and Wald tests. Results: Eighty-one patients with a mean age of 47 (range, 37-69) underwent ankle distraction with a mean follow up of 5 years (range, 3-6). All treatment strategies resulted in statistically significant improvements in FAOS (<0.001). Groups that underwent microfracture had a statistically significant decrease in post-operative plantarflexion, dorsiflexion, subtalar inversion and subtalar eversion (p=0.003) as well as an overall decrease in joint space (0.002) with persistence of subchondral bone sclerosis. Patients who underwent distraction with no microfracture treatment resulted in a significant increase in post-operative joint space (p=0.001) and decreased sclerosis in the subchondral bone. Average return to activity was 6 months in patients who received BMAC/PRP with ankle distraction compared to 12 months in patients who were treated with ankle distraction and microfracture (p<0.01). Conclusion: Distraction arthroplasty results in good functional outcomes at medium term follow up. The addition of microfracture seems to create functional outcome deterioration, whereas the addition of a biologic agent either BMAC or PRP appears to benefit earlier return to function. Longer-term studies will be required to see if these effects are sustained.
CAPS UERJ como dispositivo-acontecimento: rupturas e (des)continuidades no processo de trabalho em saúde mental | CAPS UERJ as device-event: ruptures and (dis) continuities in the work process in mental health
Authors: Coe Neilanza Micas 
Published: May 2019

Como modelo micropolítico da atenção psicossocial, cartografamos o CAPS UERJ como acontecimento, recorte evidenciado pelas narrativas dos sujeitos implicados com as suas emergências. O recurso genealógico, criado por Nietzsche ao final do século XIX e desdobrado por Michel Foucault no século seguinte, forneceu pistas para demonstrarmos as aproximações da pesquisa ao movimento de ruptura com o Hospital Dia Ricardo Montalban, representado pelo modelo psiquiátrico hospitalocêntrico medicalizador, para a emergência do CAPS UERJ e seu alinhamento com a estratégia da atenção psicossocial. Contudo, a tentativa de tradução da processualidade desse movimento evidencia rupturas, capturas e (des)continuidades do dispositivo-acontecimento pelo analisador supervisão clínico-institucional.Palavras-chaves: Reforma Psiquiátrica; Estratégia da Atenção Psicossocial, Dispositivo-Acontecimento. Abstract —We map the CAPS UERJ as a micro-political model of psychosocial care event cutting evidenced by the narratives of subjects involved into their emergencies. The genealogy resource created by Nietzsche in the late nineteenth century and deployed by the Michel Foucault in the next century, provided clues to demonstrate research approached from the rupture movement with the Ricardo Montalban Day Hospital which is represented by the psychiatric hospital centric-medicalization model from CAPS UERJ’s emergency and its alignment with the psychosocial care strategy. However, the attempt to translate the processuality of this movement reveals catches and (dis) continuity of the device event by clinical-institutional supervision analyzer.Keywords: Psychiatric reform; Psychosocial care strategy; Device-events; CAPS UERJ.
Violência estrutural contra mulheres em Belo Monte: o que os dados oficiais (não) revelam | Structural violence against women in Belo Monte: what official data does not reveal
Authors: Barroso Milena Fernandes 
Published: May 2019

A experiência de Belo Monte é emblemática por explicitar a violência contra as mulheres como condição. Neste sentido, o presente artigo trata de uma aproximação às expressões da violência de gênero neste contexto, a partir da análise dos registros oficias de violência contra as mulheres antes e depois do início das obras da UHE de Belo Monte. São problematizadas, assim, as análises que percebem o aumento dos registros como mera coincidência ou buscam uma explicação na condição masculina – no sentido de uma essência ou estrutura psicológica masculina naturalmente violenta e inabalável. A análise aponta para o distanciamento entre os dados oficiais e a realidade concreta, posto que os registros não alcançam a multiplicidade de expressões da violência no cotidiano das mulheres. Afirma-se também que a violência contra as mulheres não figura apenas como consequência ou resultado desses projetos: ela é determinante para que esses projetos possam se constituir como tal. Palavras-Chave: violência contra as mulheres; violência estrutural; Usina Hidrelétrica de Belo Monte. Abstract – Belo Monte’s experience is remarkable because it exposed violence against women as a condition. Therefore, this article is about an approximation to the expressions of violence against women before and after the beginning of the work at the Belo Monte Dam. Analyses that perceive the increase in reports as simple coincidence or that seek an explanation in the male condition – understood as a naturally violent and unyielding essence or psychological structure – are problematized. The conclusion points to a divergence between official data and concrete reality, since records do not reflect the multiplicity of expression of violence to which women are routinely subjected. It also states that violence against women does not appear only as a result or consequence of these projects, it is necessary to their very establishment.Keywords: violence against women; structural violence; Belo Monte Hydropower.
Das Parlament der Dinge: Transmateriale und transmediale Dynamiken, Bild-Ding-Relationen und „Meta-Artefakt-Malerei“
Authors: Schulz Vera-Simone 
Published: May 2019

Studies related to artifacts, to what has been traditionally categorized as ‘high’ and ‘minor’ or ‘applied arts’, and to the materiality of art in recent years have been among the core foci of art history. More scholarly attention has also been given to the intersections between visual and material culture, not least in transcultural contexts. This paper seeks to contribute to these issues. Investigating transmaterial and transmedial dynamics between the arts, image-object interrelations as well as phenomena wherein images themselves gave the impulse to the creation of artifacts, the paper analyzes transfer processes transgressing various media and materials, 15th- and 16th-century Italian and Portuguese paintings in their Mediterranean and global entanglements, as well as 19th - and 20th-century artistic and academic approaches to objects in paintings.
Poręczne obrazy, wymowne przedmioty. Retoryka rzeczowości w „L'Esprit Nouveau” Ozenfanta i Le Corbusiera
Authors: Rejniak-Majewska Agnieszka 
Published: May 2019

The paper is an attempt to draw the reader’s attention to visual reproduction as an element of modern artistic discourses and a medium of the mediated reception of art. An instrumental approach to reproduction as a neutral and ancillary vehicle of meaning, prevalent in the age of modernism, corresponded to the belief in its information efficacy and ability to overcome material, physical limitations. What mattered most were not the material, physical aspects of the existence and circulation of images, even though the avant-garde artists of the 1920s, using contemporary technology, were aware how important the medium’s and its distribution range’s “impact” was. L’Esprit Nouveau, a periodical edited in 1920-1925 by Amédée Ozenfant and Le Corbusier, was an example of a successful avant-garde strategy which let both editors, marginal in the field of art, achieve the status of “leaders” of the modernist movement, recognized or at least carefully watched by artists and critics abroad. Next to other factors, important was the visual aspect of the magazine, praised for many impressive, modern illustrations, often reproduced in other avant-garde publications. The author analyzes visual resources used and reproduced in L’Esprit Nouveau, referring to the postulates of “objectivism” and “thingness”, endorsed by the periodical, and considering the part that “ready-made” images, found in the daily press and commercial catalogues as well as on postcards. played in Le Corbusier’s polemical and programmatic texts. Their strongly persuasive message was often rooted in montage and quotations which stressed its heterogeneity. In terms of composition and aesthetics, the reproduced images supported the aesthetics of transparency, order, and thingness, so characteristic of L’Esprit Nouveau. The emblems of modernity emerged from the movement of anonymous images which acquired the value of symbols. Ozenfant’s and Le Corbusier’s use of images borrowed from popular culture, as well as from albums and art books, makes one consider not only their rhetorical effectiveness, but also their role in the creative process and thinking. In Le Corbusier’s artistic practice, those easily available, miniaturized images were a common instrument enhancing his visual, aesthetic approach. Such an approach, according to Georg Simmel, seems to be characteristic of the modernist attitude to the material world that consisted in subjective distance combined with the apparently opposite desire to “go back to things” by making them more concrete and closer to the senses.
Fixed-point subgroups of GL3(𝑞)
Authors: Cullinan John 
Published: May 2019

Abstract
Let V be a vector space over a field k.
We call a subgroup

G
⊂

GL
⁢

(
V
)

{G\subset\mathrm{GL}(V)}

a fixed-point subgroup if

det
⁡

(

1
-
g

)

=
0

{\det(1-g)=0}

for all

g
∈
G

{g\in G}

.
Let q be a power of a prime.
In this paper, we classify the fixed-point subgroups of

GL
3

⁢

(
q
)

{\mathrm{GL}_{3}(q)}

.
The first case of primary hypertrophic osteoarthropathy with soft tissue giant tumors caused by HPGD loss-of-function mutation
Authors: Pang Qianqian , Xu Yuping , Qi Xuan , Jiang Yan , Wang Ou , Li Mei , Xing Xiaoping , Qin Ling , Xia Weibo 
Published: May 2019

Background
Primary hypertrophic osteoarthropathy (PHO) is a rare genetic multi-organic disease characterized by digital clubbing, periostosis and pachydermia. Two genes, HPGD and SLCO2A1, which encodes 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and prostaglandin transporter (PGT), respectively, have been reported to be related to PHO. Deficiency of aforementioned two genes leads to failure of prostaglandin E2 (PGE2) degradation and thereby elevated levels of PGE2. PGE2 plays an important role in tumorigenesis. Studies revealed a tumor suppressor activity of 15-PGDH in tumors, such as lung, bladder and breast cancers. However, to date, no HPGD-mutated PHO patients presenting concomitant tumor has been documented. In the present study, we reported the first case of HPGD-mutated PHO patient with soft tissue giant tumors at lower legs and evaluated the efficacy of selective COX-2 inhibitor (etoricoxib) treatment in the patient.

Methods
In this study, we summarized the clinical data, collected the serum and urine samples for biochemical test and analyzed the HPGD gene in our patient.

Results
A common HPGD mutation c.310_311delCT was identified in the patient. In addition to typical clinical features (digital clubbing, periostosis and pachydermia), the patient demonstrated a new clinical manifestation, a giant soft tissue tumor on the left lower leg which has not been reported in HPGD-mutated PHO patient before. After 6-month treatment with etoricoxib, the patient showed decreased PGE2 levels and improved PHO-related symptoms. Though the soft tissue tumor persisted, it seemed to be controlled under the etoricoxib treatment.

Conclusion
This finding expanded the clinical spectrum of PHO and provided unique insights into the HPGD-mutated PHO.
Elevated serum neuregulin 4 levels in patients with hyperthyroidism
Authors: Li Min , Chen Ying , Jiang Jingjing , Lu Yan , Song Zhiyi , Zhang Shengjie , Sun Chao , Ying Hao , Fan Xiaofang , Song Yuping , Yang Jialin , Zhao Lin 
Published: May 2019

Objective
Recent studies have shown that neuregulin 4 (Nrg4), a member of the epidermal growth factor (EGF) family of extracellular ligands, plays an important role in the prevention of obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD). Considering that thyroid hormone (TH) has profound effects on whole-body energy metabolism, we speculate that circulating Nrg4 levels might be altered in patients with hyperthyroidism.

Design and methods
A total of 129 hyperthyroid patients and 100 healthy subjects were recruited. Of them, 39 hyperthyroid patients received thionamide treatment for 3 months until euthyroidism. Serum Nrg4 levels were determined using the ELISA method. To further confirm the relationship between TH and Nrg4, C57BL/6 mice were treated with T3 and quantitative real-time PCR was performed to detect Nrg4 gene expression.

Results
Serum Nrg4 levels were significantly elevated in hyperthyroid patients as compared with normal controls (3.84 ± 1.63 vs 2.21 ± 1.04 ng/mL, P < 0.001). After achieving euthyroidism by thionamide treatment, serum Nrg4 levels dropped markedly from 3.57 ± 1.26 to 1.94 ± 0.72 ng/ml (P < 0.001). After adjustment for potential confounders, serum Nrg4 levels were independently associated with hyperthyroidism. The upregulation of Nrg4 expression in the livers and white adipose tissues by T3 was further confirmed by animal and cell culture experiments.

Conclusions
Serum Nrg4 levels were increased in patients with hyperthyroidism. The liver and white adipose tissue might be primary sources contributing to elevated serum Nrg4 concentrations.
Updating the Competency Profile and Examination Blueprint for Entry-Level Optometry in Canada
Authors: Cane David , Penny Margaret , Marini Anthony , Hynes Tami 
Published: May 2019

The Optometry Examining Board of Canada (formerly Canadian Examiners in Optometry) is a not-for-profit corporation that administers the entry-to-practice examination for optometrists in Canada in service to its members, the 10 provincial optometry regulators.

The described work resulted in an updated entry-level competency profile for optometry, together with an examination blueprint based upon indicators derived from the competencies. The project took place over the period May 2014 – September 2015 and involved the following steps:

Establishment of project teams
Clarification of conceptual framework
Development of proposed competencies
Validation of competencies
Development of indicators for each competency, consistent with the assessment methodologies used in the entry-to-practice examination
Construction of an updated examination blueprint
The rise of the local food movement and its impact on rural economies: With examples from the Region of Durham
Authors: Jibb Stacey 
Published: May 2019

<p>Rural economies across North America continue to see the positive impacts of the rise of the local food movement and the evolution of the local food system. Local food is a fluid definition impacted by several factors. Government policy, geography and the personal relationships that develop between producer and consumer all play a part in shaping what is local. This has altered how consumers interact with the local food economy and has given rise to direct-farm marketing and agri-tourism as ways to participate in the local food system. Using examples from northern Durham Region, this paper examines how rural economies are impacted by the growing demand for access to local food and how that translates into direct impacts for the local economy. </p><p><strong>Keywords: </strong>local food, local food movement, rural economies, direct-farm marketing, food economy</p>
Adult Tourniquet for Use in School-Age Emergencies
Authors: Harcke H. Theodore , Lawrence Luke L. , Gripp Emily W. , Kecskemethy Heidi H. , Kruse Richard W. , Murphy Stephen G. 
Published: May 2019

BACKGROUND:Gunshot injuries are a leading cause of morbidity and mortality in the pediatric population. The Pediatric Trauma Society supports the use of tourniquets for exsanguinating hemorrhage in severe extremity trauma. The Combat Application Tourniquet (CAT) used with success in adults has not been prospectively tested in children. Our objective with this study was to determine if the CAT is successful in arresting extremity arterial blood flow in school-aged children.METHODS:Sixty school-aged volunteers (ages 6–16 years) recruited by age cohort had the CAT applied to an upper arm and thigh while peripheral pulse was monitored by Doppler. The number of windlass turns (maximum allowed: 3 [1080°]) required to arrest arterial pulse was recorded. Success was analyzed by BMI percentile for age and extremity circumference.RESULTS:The CAT was successful in occluding arterial blood flow as detected by Doppler pulse in all 60 (100%) of the upper extremities tested. In the lower extremity, 56 (93%) had successful occlusion. The 3-turn maximum allowed by the protocol was not adequate in some obese, older subjects (BMI &gt;30). In both the upper and lower extremity, the number of turns required to occlude blood flow gradually increased with an increase in arm and thigh circumference.CONCLUSIONS:Prospective testing of a cohort of school-aged children 6 to 16 years revealed the CAT tourniquet to be suitable for use in both the upper and lower extremity.
KUALITAS PERAIRAN TELUK KAYELI, KABUPATEN BURU, PROPINSI MALUKU, UNTUK BUDIDAYA LAUT DAN WISATA BAHARI
Authors: Rustam Agustin , Prabawa Fajar Y , Tussadiah Armyanda 
Published: May 2019

Kualitas perairan merupakan salah satu faktor penting dalam mendukung usaha budidaya laut dan wisata bahari yang umumnya dilakukan di sebuah perairan teluk, seperti Teluk Kayeli yang terletak di Pulau Buru. Penelitian ini bertujuan untuk menganalisis kondisi perairan Teluk Kayeli yang dimanfaatkan sebagai lokasi kegiatan budidaya laut dan wisata bahari. Pengambilan sampel air dilakukan dengan menggunakan metode survei, dengan penentuan titik sampling secara sistematis di seluruh bagian dalam teluk pada bulan Oktober 2014. Hasil penelitian menunjukkan bahwa kualitas perairan di Teluk Kayeli masih sesuai baku mutu. Sebanyak 18 jenis fitoplankton dan 8 jenis zooplankton yang ditemukan. Kelimpahan rata-rata fitoplankton 51 sel/L dengan kelimpahan tertinggi jenis Chaetoceros decipiens. Berdasarkan analisis kualitas perairan Teluk Kayeli dinilai sesuai untuk budidaya keramba jaring apung dan wisata bahari, dengan nilai nitrat 0,006 mg/L, DO (dissolved oxygen) 5,89 mg/L, salinitas 33,26 PSU dan turbiditas 0,23 NTU. Hasil penelitian ini tidak mengukur kandungan logam berat dalam perairan sehingga disarankan agar dilakukan pengukuran logam berat terkait dengan masih adanya usaha penambangan yang membuang limbah ke sungai. Berdasarkan analisis kualitas perairan penelitian ini, Teluk kayeli sesuai untuk budidaya jaring apung maupun wisata bahari sehingga diperlukan infrastruktur ramah lingkungan yang mendukung, serta kajian daya dukung Teluk Kayeli untuk dua kegiatan tersebut.
Prevention, Monitoring, and Management of Cardiac Dysfunction in Patients with Metastatic Breast Cancer
Authors: Curigliano Giuseppe , Azambuja Evandro , Lenihan Daniel , Calabrò Maria Grazia , Cardinale Daniela , Cipolla Carlo Maria 
Published: May 2019

Abstract

Cardiac monitoring is becoming an important part of breast cancer care. Breast cancer and cardiovascular disease (CVD) share many common risk factors, and it is estimated that by the median age of diagnosis, many patients with breast cancer will have established or subclinical CVD. In addition, a number of treatments for metastatic breast cancer are known to have cardiac effects. As such, there is a clear need to prevent, identify, and effectively manage cardiovascular events in patients with breast cancer. Current clinical practice for patients with metastatic breast cancer involves a comprehensive set of assessments to ensure efficacy and safety of treatment. Adding cardiac monitoring to the assessments already required for patients with breast cancer may improve survival and quality of life. Currently, cardiac monitoring is recommended for several breast cancer treatments, and guidelines related to cardiac monitoring are available. Here, we review the risk of CVD in patients with breast cancer, providing an overview of the cardiac events associated with standard therapies for metastatic breast cancer. We also assess the current clinical recommendations relating to cardiac monitoring, and practical management strategies for oncologists. Cardio-oncology is a growing medical subspecialty that promotes the need for effective cancer therapy while minimizing cardiac effects. Integrating cardiac monitoring into routine clinical practice may safeguard patients with metastatic breast cancer against adverse cardiac effects.

Implications for Practice
This review details the common risk factors associated with cardiovascular disease that are frequently observed in patients with metastatic breast cancer, as well as the adverse cardiac effects of many therapies that are commonly prescribed. The review also provides a rationale for routine and comprehensive cardiovascular assessment of all patients at baseline, and during and after therapy depending on the treatment and presence of risk factors for cardiovascular disease. The medical discipline of cardio-oncology is increasingly being recognized as an important part of clinical practice to ensure effective cancer therapy while maintaining cardiac health.
Kabarcıklı Akışkan Yataklı Bir Reaktörde Isı Geçişini Etkileyen Parametrelerin İncelenmesi
Authors: ERBAŞ Oğuzhan 
Published: May 2019

Akışkan yataklı kazanlar, konvansiyonel yakma sistemlerine
göre düşük kaliteli yakıtların değerlendirilmesi açısından ekonomik, teknolojik
ve çevreci olma özelliklerini taşımaktadır. Akışkan yatak teknolojisi, kömür,
biyokütle, endüstriyel ve evsel atıkları temiz, güvenli ve yüksek verimli bir
şekilde yakılabilmektedir. Bu bağlamda "akışkan yatakta yakma" nem ve
kükürt oranı yüksek linyitlerimizin değerlendirilmesinde, verimin artırılması
ve NOx, SO2 gibi zararlı emisyonların azaltılmasında
önemli bir seçenektir.

Akışkan yatakta, basınçlandırılan yakma havası ile yatak partikülünde
oluşturulan sürüklenme kuvveti ve yukarı yönde oluşan ortamsal kaldırma kuvveti
toplamı, aşağı yönde oluşan yatak partikül yerçekimi kuvvetleri ile
dengelenerek, yatak malzemesi kararsız yoğun türbülanslı ve sıvısal
hidrodinamik özellikli bir davranışa zorlanır. Bu davranış akışkan yatakta
hidrodinamiksel tasarımın ve ısı transfer mekanizmasının temelini oluşturur. Bu
çalışmada; kabarcıklı akışkan yataklı bir reaktörde daldırılmış yüzeyden ısı
geçişini belirleyen parametrelerin etkisi farklı test koşullarında deneysel
olarak incelenmiştir.