bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lengthy leader male tenure delays male offspring dispersal in a primate multilevel society
Authors: Fang Gu , Gao Xiao-Min , Zhang Dong , Dunn Derek , Pan Ruliang , Li Bao-Guo , Qi Xiao-Guang 
Published: September 2019

Abstract
Natal dispersals are male-biased in most Old World monkey species, especially those that are polygynous. We examined patterns of male dispersal in golden snub-nosed monkeys, in which male offspring mainly disperse as juveniles from their natal one-male units (OMUs) to a bachelor group. However, out of a total of 112 male dispersals from 2001–2016, we documented six cases in which male offspring remained in their natal OMU until sub-adulthood. Based on monitoring of dispersal dynamics, we found that male offspring were more likely to delay dispersal if the tenure of leader males was lengthy. Social network analysis showed male offspring who delayed dispersal exhibited strong social relationships with each other and their OMU leader male but not with the females of their OMU. Our results suggest that the length of leader male tenure may affect natal male dispersal due to benefits to leader males accrued via intrasexual competition and kin selection.
Material Visions of the Good Life
Authors: Félix-Jäger Steven 
Published: September 2019

Abstract
Methods within visual culture studies can reveal the aesthetic stimuli that shape the way a religious group pictures or visualizes existence. Studying the visual culture of a religious movement allows one to see what formational mechanisms already exist and how the stimuli implicitly or explicitly support the movement’s theological commitments. This article suggests an approach for understanding Pentecostalism anew in its own distinct theological and sociological terms by categorizing the contours of the religious visual cultures of global Pentecostalism. This article argues that theologies of abundance are largely at play in the visual cultures of global Pentecostalism, and this can be demonstrated by identifying the visual stimuli that form religious experience and shape the way Pentecostals around the world imagine, understand, and project reality.
Can A Transnational Law Approach Offer A Better Understanding of International Law’s Contribution to Sustainable Hydropower Projects? A Test Case from the Mekong River Basin
Authors: Mayard Laure-Elise 
Published: September 2019

Hydropower regulation involves an increasingly complex set of actors, scales and legal regimes. The role that international law plays in regulating hydropower, and other sustainable development issues, is challenged by this pluralism because of international law’s restrictive traditional theoretical framework, which appears to be ill-equipped to fully grasp and represent significant features of pluralistic regulation. A broader conceptualization of international law could create a more pluralist, holistic and integrated approach to regulation, making it more attuned to reality and to sustainable development objectives.
This article adopts a transnational law approach embracing in a more flexible manner different elements which influence regulation and which escape existing legal categories. Hydropower projects in the Lower Mekong River Basin illustrate the mismatch between regulation mainly focused on the State, investment-related actors and regimes of large projects, on the one hand, and the growing pluralism driven by the involvement of non-State actors, specificities of environmental regulation and different levels of inquiry, on the other hand. The analysis explores the ‘blind spots’ of international law in its regulation of hydropower projects and considers the possibilities in which a transnational law approach broadens the vision of existing international law to be more pluralist.
Evaluation and Comparison of CanRCM4 and CRCM5 to Estimate Probable Maximum Precipitation over North America
Authors: Ben Alaya M. A. , Zwiers F. , Zhang X. 
Published: September 2019

AbstractRecently dam managers have begun to use data produced by regional climate models to estimate how probable maximum precipitation (PMP) might evolve in the future. Before accomplishing such a task, it is essential to assess PMP estimates derived from regional climate models (RCMs). In the current study PMP over North America estimated from two Canadian RCMs, CanRCM4 and CRCM5, is compared with estimates derived from three reanalysis products: ERA-Interim, NARR, and CFSR. An additional hybrid dataset (MSWEP-ERA) produced by combining precipitation from the Multi-Source Weighted-Ensemble Precipitation (MSWEP) dataset and precipitable water (PW) from ERA-Interim is also considered to derive PMP estimates that can serve as a reference. A recently developed approach using a statistical bivariate extreme values distribution is used to provide a probabilistic description of the PMP estimates using the moisture maximization method. Such a probabilistic description naturally allows an assessment of PMP estimates that includes quantification of their uncertainty. While PMP estimates based on the two RCMs exhibit spatial patterns similar to those of MSWEP-ERA and the three sets of reanalyses on the continental scale over North America, CanRCM4 has a tendency for overestimation while CRCM5 has a tendency for modest underestimation. Generally, CRCM5 shows good agreement with ERA-Interim, while CanRCM4 is more comparable to CFSR. Overall, the good ability of the two RCMs to reproduce the major characteristics of the different components involved in the estimation of PMP suggests that they may be useful tools for PMP estimation that could serve as a basis for flood studies at the basin scale.
Ocean Eddy Energetics in the Spectral Space as Revealed by High-Resolution General Circulation Models
Authors: Wang Shengpeng , Jing Zhao , Zhang Qiuying , Chang Ping , Chen Zhaohui , Liu Hailong , Wu Lixin 
Published: September 2019

AbstractIn this study, the global eddy kinetic energy (EKE) budget in horizontal wavenumber space is analyzed based on 1/10° ocean general circulation model simulations. In both the tropical and midlatitude regions, the barotropic energy conversion from background flow to eddies is positive throughout the wavenumber space and generally peaks at the scale (Le) where EKE reaches its maximum. The baroclinic energy conversion is more pronounced at midlatitudes. It exhibits a dipolar structure with positive and negative values at scales smaller and larger than Le, respectively. Surface wind power on geostrophic flow results in a significant EKE loss around Le but deposits energy at larger scales. The interior viscous dissipation and bottom drag inferred from the pressure flux convergence act as EKE sink terms. The latter is most efficient at Le while the former is more dominant at smaller scales. There is an evident mismatch between EKE generation and dissipation in the spectral space especially at the midlatitudes. This is reconciled by a dominant forward energy cascade on the equator and a dominant inverse energy cascade at the midlatitudes.
Pleuropulmonary blastoma: a report from the TREP (Tumori Rari in Età Pediatrica) Project
Authors: Grigoletto Veronica , Tagarelli Arianna , Atzeni Catia , Cecchetto Giovanni , Indolfi Paolo , De Pasquale Maria Debora , De Leonardis Francesco , Coppadoro Beatrice , Sorbara Silvia , Chiaravalli Stefano , Ferrari Andrea , Bisogno Gianni 
Published: September 2019

Introduction: Pleuropulmonary blastoma (PPB) is a rare, aggressive mesenchymal tumor of childhood. The Italian Tumori Rari in Età Pediatrica (TREP) Registry was the first in Europe dedicated to prospective data collection on rare pediatric tumors. We analyzed data from an Italian series of patients with PPB, focusing on the role of the TREP Project. Methods: We considered patients aged 0–14 with histologically confirmed diagnosis, registered in population-based cancer registries (before 2000) or the TREP Registry (2000 to 2014), and analyzed data on clinical characteristics, treatment, and outcome. Event-free survival (EFS) and overall survival (OS) were estimated. Relevant prognostic factors were identified performing a univariate analysis. Results: Thirty-seven cases were included (7 type I, 13 type II, 17 type III). The average diagnosis rate rose from 1.10 to 1.73 cases/year after the TREP Project started. All patients underwent surgery, 33 received chemotherapy, and 9 had radiotherapy. The median follow-up was 8.7 years. For type I, II, and III, respectively, the 5-year OS was 85.7% (33.4–97.9), 52.7% (23.4–75.5), and 57.8% (31.1–77.3); the 5-year EFS was 85.7% (33.4–97.9), 52.7% (23.4–75.5), and 52.9% (27.6–73.0). Favorable prognostic factors for EFS were Intergroup Rhabdomyosarcoma Study (IRS) stage I ( p = 0.03) and T1 tumor ( p = 0.05). A total of 78.3% of patients who had chemotherapy after 2000 received a standardized treatment. Conclusions: The TREP Registry showed an excellent capacity for registering cases of PPB. Patients received homogeneous treatment after the TREP Project started. Long-term outcomes were excellent for type I and unsatisfactory for type II and III. Tumor invasiveness and IRS stage were of prognostic value.
Building capacity for child and adolescent mental health and psychiatry in Papua New Guinea
Authors: Kowalenko Nick , Hagali Monica , Hoadley Benjamin 
Published: September 2019

Objective: To describe the recent work of child psychiatrists in Australia, New Zealand (ANZ) and Papua New Guinea (PNG) adding to mental health capacity building across the life-span, starting with children and adolescents. Method: Concerns about treatment access and clinical training needs, combined with academic leadership and National Department of Health commitment, supported the collaborative involvement of the Royal Australian and New Zealand College of Psychiatry (RANZCP) in workforce development. This has been initially established under the auspices of the Faculty of Child and Adolescent Psychiatry (FCAP). Results: Workforce development in child and adolescent mental health is underway, with sustainability, consolidation and scaling up of initiatives required to meet need. Conclusions: Expanding mental health workforce capacity in partnership with the National Department of Health and the University of Papua New Guinea (UPNG) seems feasible. Ongoing cooperation is required to realize the potential of such collaborative initiatives.
Immediate Effect of Fan Therapy in Terminal Cancer With Dyspnea at Rest: A Meta-Analysis
Authors: Kako Jun , Kobayashi Masamitsu , Oosono Yasufumi , Kajiwara Kohei , Miyashita Mika 
Published: September 2019

Background: Dyspnea is a common distressing symptom in patients with malignant and nonmalignant diseases. Fan therapy, which uses a fan to blow air toward the patient’s face, can alleviate dyspnea; however, its efficacy remains unclear. Aim: To examine the immediate efficacy of fan therapy for alleviation of dyspnea at rest. Design: Meta-analysis. Data sources: We searched the Cochrane Central Register of Controlled Trials in the Cochrane Library, MEDLINE EBSCO, CINAHL EBSCO, and Scopus from January 1, 1987, to August 21, 2018 (PROSPERO-CRD42018108610). In addition, we hand-searched studies and used the similar articles feature on PubMed to search for articles. Randomized controlled trials comparing the effects of fan therapy with placebo or other interventions to alleviate dyspnea at rest, in which patients were aged ≥18 years, were eligible for inclusion in the review. We excluded articles on long-term intervention involving fan therapy and complex intervention (including fan therapy). The risk of bias assessment was conducted using the Cochrane tool, and the meta-analysis was performed using RevMan version 5.3. Results: We identified a total of 218 studies; 2 met our criteria for inclusion in the meta-analysis. Fan therapy significantly improved dyspnea at rest in terminally ill patients with cancer compared to control groups (mean difference: −1.31, 95% confidence interval: −1.79 to −0.83, P < .001). There were no studies that met the inclusion criteria regarding fan therapy for patients with nonmalignant disease. Conclusions: This meta-analysis demonstrated that fan therapy may be an effective intervention for dyspnea at rest in patients with terminal cancer.
Application of an innovative high-throughput liquid chromatography-tandem mass spectrometry method for simultaneous analysis of 18 hazardous drugs to rule out accidental acute chemotherapy exposures in health care workers
Authors: Shu Pan , Zhao Ting , Wen Bo , Mendelsohn-Victor Kari , Sun Duxin , Friese Christopher R , Pai Manjunath P 
Published: September 2019

Objectives Despite safe handling guidelines published by several groups, health care worker exposure to hazardous drugs continues to occur due to suboptimal engineering controls and low use of protective equipment. Simple, multi-target and specific analytical methods are needed so that acute exposures to these drugs in the workplace can be assessed rapidly. Our aim was to develop an analytical method for simultaneous detection and quantification of widely used cancer drugs to rule out accidental acute chemotherapy exposures in health care workers. Methods We examined the feasibility of alternate high-performance liquid chromatographic-tandem mass spectrometry methods to simultaneously detect eighteen chemotherapy analytes in plasma and urine. The linear concentration ranges tested during assay development were 0.1–50 ng/mL. After development of a multi-analyte assay protocol, plasma samples (n = 743) from a multi-center cluster-randomized clinical trial (n = 12 sites) of an hazardous drug educational intervention were assayed. Confirmatory assays were performed based on the individual acute-spill case-histories. Results An innovative HPLC-multiple reaction monitoring-information dependent acquisition-enhanced production ion (MRM-IDA-EPI) analytical method was developed to simultaneously detect: cytarabine, gemcitabine, dacarbazine, methotrexate, topotecan, mitomycin, pemetrexed, irinotecan, doxorubicin, vincristine, vinblastine, ifosamide, cyclophosphamide, vinorelbine, bendamustine, etoposide, docetaxel, and paclitaxel. The retention times ranged from 4 min to 13 min for the analytical run. The limit of detection (MRM-IDA-EPI) and limit of quantitation (MRM) was 0.25 ng/mL and 0.1 ng/mL, respectively for most analytes. No detectable plasma concentrations were measured at baseline, post-intervention and in cases of documented acute spills. Use of a secondary tandem mass spectrometry approach was able to successfully rule out false positive results. Conclusions Development of a sensitive high-throughput multi-analyte cancer chemotherapy assay is feasible using an MRM-IDA-EPI method. This method can be used to rapidly rule out systemic exposure to accidental acute chemotherapy spills in health care workers.
Challenges in integrating health and social care: the Better Care Fund in England
Authors: Harlock Jenny , Caiels James , Marczak Joanna , Peters Michele , Fitzpatrick Raymond , Wistow Gerald , Forder Julien , Jones Karen 
Published: September 2019

Objectives The Better Care Fund is the first and only national policy in England that has legally mandated the use of pooled budgets to support local health and social care systems to provide better integrated care. Methods We report qualitative findings from the first national multi-method evaluation of the Better Care Fund, focusing on its implementation, perceptions of progress and expected impacts among key stakeholders. Interviews were carried out with 40 staff responsible for Better Care Fund implementation in 16 local health and social care sites between 2017 and 2018. Results Study participants reported their experiences of implementation, and we present these in relation to three themes: organizational issues, relational issues and wider contextual issues. Participants stressed the practical and political challenges of managing pooled budgets and the complexity of working across geographical boundaries. In a context of unprecedented austerity, shared vision and strong leadership were even more vital to achieve collaborative outcomes. Conclusion Pooling budgets through the Better Care Fund can lever closer collaboration between sectors and services. Shared vision and leadership are essential to develop and foster this closer collaboration. Although some successes were reported, the study highlights that there are major cultural, operational and territorial barriers to overcome.
Effects of combined statin and ACE inhibitor therapy on endothelial function and blood pressure in essential hypertension - a randomised double-blind, placebo controlled crossover study
Authors: Ruszkowski Piotr , Masajtis-Zagajewska Anna , Nowicki Michał 
Published: September 2019

Background: The aim of this study was to compare the influence of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on endothelial function and blood pressure in patients with essential hypertension on long-term angiotensin-converting enzyme inhibitor therapy. Method: The study was designed as a prospective, double-blind, randomised, placebo controlled, crossover clinical trial. Twenty patients with essential hypertension were treated with an angiotensin-converting enzyme inhibitor; the control group included 10 healthy subjects. Hypertensive patients received in random order 80 mg of fluvastatin daily or placebo for 6 weeks. The following parameters were assessed at baseline and after each treatment period: serum lipids, flow-mediated vasodilation, activity of von Willebrand factor, concentration of vascular endothelial growth factor, C-reactive protein and 24-hour blood pressure profile. Results: Hypertensive patients did not differ from healthy subjects with respect to age, body mass and biochemical parameters, with the exception of C-reactive protein, which was higher in hypertensive patients ( P=0.02). After statin therapy, low-density lipoprotein cholesterol ( P<0.0001), C-reactive protein ( P=0.03), von Willebrand factor ( P=0.03) and vascular endothelial growth factor ( P<0.01) decreased and flow-mediated vasodilation improved ( P<0.001). Statins had no significant effect on blood pressure. Conclusions: Statins added to angiotensin-converting enzyme inhibitors may improve endothelial function and ameliorate inflammation independently of blood pressure.
Metascience: Guidelines for the Practitioner
Authors: Turner John R. , Brown H. Quincy , Passmore David L. , Nimon Kim , Baker Rose , Jeong Shinhee , Flatt Candace 
Published: September 2019

The Problem The trend in current research is to seek a statistically significant finding, one that provides a p value less than a predetermined alpha. Unfortunately, a large number of research studies have been identified as being nonreplicable along with having other shortcomings (low power, improper methodology, poor sample size) that reduce the rigor of a study’s research findings. Additional techniques are needed beyond relying solely on a p value. The Solution This article presents recommendations that Human Resource Development (HRD) scholars and scholar-practitioners can implement to improve the rigor of the discipline’s research and practice. This article also provides guidelines (higher power, meta-analyses, low bias in large studies) of how to best avoid producing nonreplicability studies along with recommendations for the larger field, in this instance for scholars and scholar-practitioners in the social sciences. The Stakeholders Scholars, scholar-practitioners, employees, and researchers who are impacted by changes in their environment due to less-than rigorous evidence-based research findings.
Serum levels of TIMP-1 and MMP-7 as potential biomarkers in patients with metastatic colorectal cancer
Authors: Vočka Michal , Langer Daniel , Fryba Vladimir , Petrtyl Jaromir , Hanus Tomas , Kalousova Marta , Zima Tomas , Petruzelka Lubos 
Published: September 2019

Objective: Tissue inhibitor of metalloproteinases 1 (TIMP-1) and matrix metalloproteinase 7 (MMP-7) were reported to have potent growth promoting activity. Lack of balance between MMPs and TIMPs is an important factor in the development of gastrointestinal malignancies. Methods: We collected serum samples from 97 patients with metastatic colorectal cancer and 79 samples from healthy controls. Serum levels of TIMP-1 and MMP-7 were measured immunochemically and compared with standard tumor markers carcinoembryonic antigen and CA19-9. Results: Serum levels of TIMP-1 and MMP-7 were significantly higher in patients with colorectal cancer compared to healthy controls (both, P < 0.001). TIMP-1 and MMP-7 correlate with the presence of colon involvement (P = 0.001; P = 0.012) and the presence of liver metastases (P = 0.002; P = 0.037), and negatively correlate with pulmonary metastases (P = 0.014; P = 0.005). MMP-7 had similar sensitivity and the same specificity as carcinoembryonic antigen. TIMP-1 and MMP-7 had better sensitivity than CA19-9. TIMP-1 and MMP-7 level correlate with worse outcome (P = 0.002). Conclusion: The results indicate that TIMP-1 and MMP-7 are effective biomarkers in patients with metastatic colorectal cancer with good sensitivity. TIMP-1 and MMP-7 levels strongly correlate with the extent of liver disease and have prognostic value.
INtravenous Iron to Treat Anaemia following CriTical care (INTACT): A protocol for a feasibility randomised controlled trial
Authors: Shah Akshay , Marian Ioana , Dutton Susan J , Barber Vicki S , Griffith David M , McKechnie Stuart R , Chapman George , Robbins Peter A , Young Duncan , Walsh Timothy S , Stanworth Simon J 
Published: September 2019

Background Anaemia is common in patients who survive critical illness and is associated with high levels of fatigue and poor quality of life. In non-critically ill patients, treating anaemia with intravenous iron has resulted in meaningful improvements in quality of life, but uncertainties regarding the benefits, risks, timing and optimal route of iron therapy in survivors of critical illness remain. Methods / Design INtravenous Iron to Treat Anaemia following CriTical care (INTACT) is an open-label, feasibility, parallel group, randomised controlled trial with 1:1 randomisation to either intravenous iron (1000 mg ferric carboxymaltose) or usual medical care. The primary objective is to assess the feasibility of a future, multicentre randomised controlled trial. Participants will be followed up for up to 90 days post-randomisation. The primary outcome measures, which will be used to determine feasibility, are recruitment and randomisation rates, protocol adherence and completeness of follow-up. Secondary outcome measures include collecting clinical, laboratory, health-related quality of life and safety data to inform the power calculations of a future definitive trial. Conclusion Improving recovery from critical illness is a recognised research priority. Whether or not correcting anaemia, with intravenous iron, improves health-related quality of life and recovery requires further investigation. If so, it has the potential to become a rapidly translatable intervention. Prior to embarking on a phase III multicentre trial, a carefully designed and implemented feasibility trial is essential.