bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunonkologie trifft Intensivmedizin: CAR-T-Zellen
Authors: Böll Boris , Borrega Jorge Garcia , Schellongowski Peter , Subklewe Marion , von Bergwelt-Baildon Michael 
Published: September 2019

AbstractCAR-T cells, genetically modified tumor-targeted t-cells, revolutionized the treatment of refractory B-cell malignancies. CAR-T cell treatment however, is invariably associated with severe immune-mediated toxicities, namely Cytokine Release Syndrome (CRS) and neurological toxicity (CRES/ICANS). Although knowledge on the pathomechanism of these toxicities is still very limited, recent findings including mouse models might allow prediction, earlier recognition and targeted treatment of patients suffering from these potentially life-threatening side effects. This article summarizes current knowledge and recent findings on the management of severe CAR-T associated toxicities and gaps of knowledge stressing the importance of an interdisciplinary approach including hematology-oncology and Intensive Care Medicine.
Intensivmedizinische Versorgung des kritisch kranken Tumorpatienten – Status Quo 2019
Authors: Beutel Gernot , Kiehl Michael , Stemmler Joachim , Shimabukuro-Vornhagen Alexander , Staudinger Thomas 
Published: September 2019

AbstractIn Europe, up to 25 % of the ICU patients suffer from malignant diseases. Recent studies have shown that the short term prognosis of critically ill cancer patients is determined by the severity of the acute complication leading to ICU admission, but not by the underlying malignancy. Long-term prognosis of cancer patients surviving the ICU however is given by the underlying disease and comparable to cancer patients never admitted to the ICU. In particular, survival rates of tumor patients admitted after surgery are equal to those from surgical non-tumor patients. Despite this favorable trend the ICU admission of patients suffering from malignancy is still debatable.To define admission criteria a triage system has been developed taking into account the prognosis of the underlying disease, the overall performance status, patient will and the severity of complications. Those criteria allow us to categorize patients and to grade the intensity of treatment into “full code” treatment, a limited “ICU trial”, or palliative care without ICU intervention. In addition to those, additional factors of adverse prognosis as low performance status, number of comorbidities, admission due to cardiorespiratory arrest, organ failure due to malignancy, aspergillosis or admission after allogeneic stem cell transplantation have been identified.This complexity requires an interdisciplinary cooperation between oncologists/haematologists and intensive care specialists and seems to be an essential clue to successfully manage critically ill cancer patients. For the future the improvement of education and training, the development of individualized therapies, and to seize the opportunity to use modern tools of data analytics and machine learning are important goals in this field.
Rechtsatriale Thromben als Komplikation bei Hämodialysekathetern und zentralen Venenkathetern
Authors: Kavalerchyk Vladyslav , Stöbe Stephan , Hagendorff Andreas , Augustyniak Jaroslaw , Staudt Alexander 
Published: September 2019

Zusammenfassung
Anamnese Fall 1: Vorstellung einer 65-jährigen Patientin mit Nachweis multipler zerebraler Infarktläsionen, nach mikrochirurgischer Resektion einer benignen Raumforderung, zur TTE/TEE zur Detektion kardialer Embolie-Quellen. Perioperativ erfolgte die Anlage eines zentralen Venenkatheters. Fall 2: Vorstellung einer 59-jährigen Patientin zur TTE/TEE bei Verdacht auf Endokarditis im Rahmen einer Urosepsis infolge einer infizierten Harnstauungsniere links bei disloziertem Doppel-J-Katheter. 4 Monate zuvor wurde ein Vorhofkatheter angelegt.
Diagnostik/Befunde In beiden Fällen konnten mithilfe der Echokardiografie thrombotische Formation im Bereich des rechten Vorhofs detektiert werden. In Fall 2 konnten zudem morphologische und funktionelle Veränderungen des rechten Vorhofs und Ventrikels sowie der Trikuspidalklappe nachgewiesen werden.
Therapie und Verlauf Während bei der Patientin in Fall 1 eine medikamentöse therapeutische Antikoagulation mit Phenprocoumon durchgeführt wurde, wurde bei der Patientin in Fall 2, v. a. aufgrund des erhöhten thromboembolischen Risikos und der funktionellen Beeinträchtigung der Trikuspidalklappe, die Indikation zur chirurgischen Thrombektomie gestellt.
Folgerung Mithilfe der Echokardiografie können thrombotische Formationen des rechten Herzens detektiert werden. Das weitere Therapieregime sollte jeweils individuell und interdisziplinär festgelegt werden.
Comparison of International Therapy Guidelines with Regard to the Treatment of Malignant Catatonia
Authors: Schönfeldt-Lecuona Carlos , Cronemeyer Maximilian , Hiesener Lilli , Connemann Bernhard J. , Gahr Maximilian , Sartorius Alexander , Mühlbauer Viktoria 
Published: September 2019

Abstract
Objective Malignant catatonia (MC) is an extremely rare, life-threatening disorder. It is characterized by catatonic symptoms accompanied by autonomic instability, hyperthermia, and changes in laboratory values. In many cases, MC is not recognized as such. Evidence-based guidelines are essential to ensure quality of treatment, but what do current national and international guidelines recommend?
Method Online search for international guidelines from English-, French-, Italian-, and German-speaking countries whose medical care meets high standards addressing the treatment of MC. These were analyzed and compared regarding statements on MC, recommendations, and strength of scientific evidence.
Results Fifteen of the identified guidelines were included. Only 5 of 15 comment on the treatment of MC. As for other rare diseases, no detailed recommendations are available. Suggested therapies are limited to benzodiazepines and electroconvulsive therapy. Levels of evidence and grades of recommendation are predominantly low.
Conclusion Many international guidelines do not mention MC. It is not possible to derive a clear algorithm for the treatment of MC from most current guidelines. A thorough update of most guidelines appears to be necessary. Lack of awareness and knowledge of MC among physicians and medical professionals might lead to inadequate or delayed care, worsened outcome, or death.
Work–Life Integration and Time Management Strategies
Authors: Gade Lindsey , Yeo Heather L. 
Published: September 2019

AbstractWhen choosing a career as a surgeon, we knowingly dedicate ourselves to a lifetime of service and education. Our commitment as physicians is but one of many commitments in the larger scheme of life where we function as family members, friends, athletes, and numerous other roles. Work and life are often described as two separate entities diametrically opposed to each other. In reality, personal and professional goals are part of a continuum where work is a major part of our lives and who we are as people and is not necessarily separate from the others. The goal-directed nature with which we approach our responsibilities as surgeons should be applied to all domains of life. As we progress along the training paradigm from intern to attending, control over time allocation increases. Understanding oneself, determining priorities, applying realistic expectations, cultivating a supportive environment, setting personal and professional goals, and being held accountable for progress and completion of these goals will allow us to utilize limited time efficiently to achieve what we individually desire from life.
Alergia alimentar ao trigo
Authors: Pinto Aline Pereira Reis , de Mello Elza Daniel 
Published: September 2019

ResumoA alergia alimentar é o nome dado para as reações adversas aos alimentos que circundam mecanismos imunológicos, ocasionando então uma gama de manifestações clínicas. Aproximadamente 6% das crianças com idade inferior a 3 anos, e cerca de 4% dos adultos apresentam desordens alérgicas causadas por alimentos. A alergia alimentar ao trigo (AAT) ocorre quando o sistema imunológico do organismo se torna sensível e reage a qualquer uma das proteínas do trigo. A reação alérgica é classificada conforme o mecanismo imunológico implicado, podendo ser mediada por IgE ou por reações mistas, quando ocorre o envolvimento de citocinas e linfócitos T pró-inflamatórios, ou imunocomplexos, ou ainda reações citotóxicas. O presente estudo tem por objetivo fazer uma revisão sobre a alergia alimentar ao trigo (AAT), englobando sua manifestação clínica, diagnósticos, e tratamento. A pesquisa de estudos foi feita nas bases de dados de referência Lilacs e Scielo, utilizando os seguintes descritores em saúde: alergia, reação alérgica e trigo. Em relação ao tratamento, o mais eficiente e garantido ainda é a extração absoluta do alérgeno da dieta, no caso do trigo. Diante das considerações, o referido estudo verificou a preocupação frequente quanto ao aumento das alergias alimentares em nível mundial, e salienta-se a importância de novos estudos relacionados ao tratamento dos alérgicos ao trigo no intuito de reduzir as reações alérgicas, manter o estado nutricional, e aumentar a qualidade de vida.
A Follow-up Study of Overweight Children and Adolescents with Diet Therapy Adjusted by Indirect Calorimetry
Authors: Koglin Gabriela , Nogueira-de-Almeida Carlos Alberto , Beghetto Mariur Gomes , Mello Elza Daniel de 
Published: September 2019

Abstract
Introduction Changes in lifestyle have led to an increase in the prevalence of excess weight. Several interventions intended to reverse this situation have been tested.
Methods We evaluated changes in the z-score for body mass index in children and adolescents after dietary management adjusted by indirect calorimetry. During 1 year, a monthly follow-up was performed on 27 children and adolescents (8–15 years) with overweight/obesity (z-score for body mass index ≥ + 1); body weight and stature measurements were collected at inclusion, at 6, and at 12 months after indirect calorimetry. Each participant received a diet adjusted by the value of indirect calorimetry. The basal metabolic rate (BMR) was evaluated to understand how to behave according to the bodily changes induced by the intervention. For statistical analyses, repeated-measures analysis of variance (ANOVA) were performed.
Results The z-score for body mass index showed a reduction by the end of the study (-0.17 ± 0.05 [p = 0.014]). The BMR dropped during the first 6 months but returned to baseline values after 12 months (p = 0.231).
Conclusion Dietary management adjusted by BMR for obese children and adolescents with excess weight, with monthly appointments, was effective after 12 months of intervention; the weight loss did not cause significant change of BMR in this period.
Licopeno e prevenção do câncer de próstata: Uma revisão integrativa
Authors: Bôto Edilayne Gomes , Kobal Priscila Sala , Ferreira Francisco Valdicélio , Lopes Letícia Bandeira Mascarenhas , Silva Antonia Smara Rodrigues , Nascimento Neto Francisco das Chagas 
Published: September 2019

ResumoAtualmente, o câncer de próstata configura-se como um importante problema de saúde pública, sendo um dos principais tipos de carcinoma diagnosticados em pacientes do sexo masculino, e tornando-se a causa primordial de morbimortalidade. Estudos têm evidenciado que hábitos e estilo de vida, juntamente com a instalação de um quadro de estresse oxidativo, apresentam-se como importantes fatores implicados no processo de carcinogênese. Em contrapartida, o hábito alimentar tem sido considerado como um aliado significativo na prevenção do câncer, por meio de grupos alimentares com propriedades antioxidantes e anti-inflamatórios capazes de atuar como compostos anticarcinogênicos, incluindo o licopeno, que é considerado um nutriente quimiopreventivo antioxidante. A presente revisão resume alguns resultados relevantes sobre o papel do licopeno na prevenção do câncer de próstata durante os últimos 7 anos. Foram selecionados artigos provenientes das seguintes bases de dados: Scielo, Lilacs, BVS, PubMed, e MEDLINE. De acordo com os critérios de inclusão e de exclusão, foram selecionados 20 artigos internacionais. Em revisões blibliográficas, ensaios clínicos (in vivo e in vitro) evidenciaram a influência da suplementação e do consumo de licopeno a partir de diferentes fontes de produtos à base de tomate e de outros alimentos-fontes na diminuição da viabilidade celular das células prostáticas após o tratamento, além de um aumento da apoptose e da regulação dos níveis transcricionais, apontando o licopeno como um importante fitoquímico. Entretanto, futuras triagens clínicas com o uso de licopeno devem ser realizadas para que seja possível estabelecer recomendações precisas sobre o consumo e a quantidade adequados do referido composto para que este seja utilizado para a prevenção do câncer de próstata.
Future Food: Sustainable Diets for Healthy People and a Healthy Planet
Authors: Wiseman Sheila A. , Dötsch-Klerk Mariska , Neufingerl Nicole , Martins Fernanda de Oliveira 
Published: September 2019

AbstractThe current food system is associated with poor health outcomes, food insecurity, and significant environmental damage. While, globally, more than enough food calories are produced than theoretically needed, this does not guaranty a good quality diet for all. At the same time, the environmental pressures of the current food system threaten several planetary boundaries, which define the environmental limits within which humans can safely operate. This narrative review gives a brief overview of the shortcomings of the current food system regarding its impact on nutrition, health, and the environment. It outlines recent advancements in the development of guidelines for a healthy and sustainable diet and discusses options on how to realize such a dietary transformation, involving all stakeholders in the food value chain.
A Multidisciplinary Approach to Dental Erosion: A Case Report
Authors: Guldag M. Ustun , Buyukkaplan U. Sebnem , Ay Zuhal Yetkin , Katirci Gunseli 
Published: September 2019

ABSTRACTChemical erosion is the loss of superficial tooth structure by chemical action in the continued presence of demineralizing agents. This can be prominent in patients with oral habits such as constant citrus ingestion (like lemon chewing), chlorinated swimming pool water or gastrointestinal problems that produce repeated exposure of teeth to gastric acids. In this case report, a multidisciplinary approach to restore the severe wear due to dental erosion by proper techniques and materials was presented. (Eur J Dent 2008;2:110-114)
Adhesion of Two Bonding Systems to Air-Abraded or Bur-Abraded Human Enamel Surfaces
Authors: Sengun Abdulkadir , Orucoglu Hasan , Ipekdal Ilknur , Ozer Fusun 
Published: September 2019

ABSTRACTObjectives: The purpose of this in vitro study was to evaluate whether mechanical alteration of the enamel surfaces with air abrasion and bur abrasion techniques could enhance the bonding performance of a three step and a self etching adhesive resin systems to enamel.Methods: 126 extracted lower human incisor teeth were used. The teeth were divided into three groups including 40 teeth each. First group; teeth were used as control and no preparation was made on enamel surfaces, 2nd group; outer enamel surfaces were air abraded, 3rd group; outer enamel surfaces were abraded mechanically with a diamond fissure bur. Cylinder composite resin blocks were bonded to the buccal enamel surfaces with two bonding systems (20 specimens in each group). Bond strengths to enamel surfaces were measured at a cross-head speed of 1 mm/min. The data were analyzed by ANOVA and Duncan Tests. To examine interface composite resin/enamel surfaces at scanning electron microscopy, remaining 6 teeth were used. Fracture analysis was performed using an optical stereomicroscope.Results: Bond strengths values of Solid Bond were significantly higher than bond strengths of Clearfil SE Bond for all types of enamel (P<.05). Shear bond strength values obtained with Solid Bond (three step system) to three types of enamel surfaces [air-abraded (30.25±7.00 MPa), bur-abraded (29.07±3.53 MPa), control (31.74±7.35 MPa)] were close to each other (P>.05). The macroscopic mode of failures for bonding systems, SB and SE Bond appeared to be adhesive and cohesive in nature.Conclusions: In order to get better bond strength values with self etching systems, it is advisable to prepare enamel surfaces with bur or air abrasion, but it enamel preparation is not necessary for
three step systems. (Eur J Dent 2008;2:167-175)
Impacted Primary Tooth and Tooth Agenesis: A Case Report of Monozygotic Twins
Authors: Zengin A. Zeynep , Sumer A. Pinar , Karaarslan Emine 
Published: September 2019

ABSTRACTIn the present report, a case of 19 year-old monozygotic twin brothers with similar tooth agenesis
and impacted primary teeth is presented. Both twins (HDH, DHH) had agenesis of ten and eleven teeth (respectively), third molars excluded, consistent with oligodontia and both had four impacted primary teeth and the permanent successors of all these primary teeth were congenitally missing. The occurrence of similarly located tooth agenesis and primary impacted teeth in monozygotic twins may suggest the influence of genetic factors in their etiology. In addition, primary tooth impaction may be related to congenitally missing tooth. (Eur J Dent 2008;2:299-302)
Wound Healing Effects of Arnebia Densiflora Root Extracts on Rat Palatal Mucosa
Authors: Kosger H. Huseyin , Ozturk Mustafa , Sokmen Atalay , Bulut Eray , Ay Sinan 
Published: September 2019

ABSTRACTObjectives: The aim of this study was to investigate wound healing effects of Arnebia densiflora (Nordm.) Ledeb. root extracts on rat palatal mucosa.Methods: A 10-mm full-thickness mucosal wounds were created on midline of rats’ palate by using scalpel. Inthe experimental groups, a ten percent extract of A. densiflora roots was topically applied once a day as ointment on the wounds. After wounding, tissue samples from palatal mucosa were harvested at 4, 7, 14 and 21 days and then evaluated histologically.Results: It was observed that 10% A. densiflora root extract has progressive effects on wound healing in experimental groups.Conclusions: This study suggests that A. densiflora root extract could be developed as a therapeutic agent for wound healing. (Eur J Dent 2009;3:96-99)
Impacted Teeth and Mandibular Fracture
Authors: Metin Murat , Şener İsmail , Tek Mustafa 
Published: September 2019

ABSTRACTObjectives: In this retrospective study, we measured the relationship between the presences of impacted or unerupted teeth in the mandible and mandibular fractures.Methods: The records and radiographs of 41 patients with mandibular fracture associated with impacted or unerupted teeth were examined. The presence of impacted or unerupted teeth were assessed for each patient and related to the occurrence of fractures of mandible.Results: Patients with fracture in the impacted or unerupted teeth area present had a 1,73 times greater chance of an mandibular fracture than patients with no fracture in the impacted or unerupted teeth area. There was a statistically significant variation in the risk for a mandibular fracture depending on impacted or unerupted teeth presence (x2=5.29, P< .05).Conclusion: The presence of an impacted or unerupted teeth significantly increases the likelihood of an mandibular fracture. (Eur J Dent 2007;1:18-20)
Stress Analysis of a Maxillary Central Incisor Restored with Different Posts
Authors: Adanir Necdet , Belli Sema 
Published: September 2019

ABSTRACTObjectives: To evaluate the effects of different post materials on the stress distribution in an endodontically treated maxillary incisor.Materials and Methods: A pseudo 3-dimensional finite element model was created in a labiolingual cross-sectional view of a maxillary central incisor and modified according to five posts with different physical properties consisting stainless steel, titanium, gold alloy, glass fiber (Snowpost), and carbon fiber (Composipost). A 200 N force was then applied from two different directions; a) vertical load on the incisal edge, b) 45 degree diagonal load above the cingulum location. Stress distribution and values were then calculated by considering the pseudo three dimensional von Mises stress criteria.Results: Under two loading conditions, post made of steel showed greatest stress concentration at the post/dentin interface followed by titanium, gold alloy, Snowpost and Composipost. However, Composipost, which elastic modulus was closer to the dentin, produced highest stress values at 1/3 cervical area.Conclusions: Within the limitation of this simulated mechanical analysis, we can conclude that the physical characteristics of posts were important on stress distributions in post and core applications. Glass fiber post revealed more balanced stress distribution under functional forces. (Eur J Dent 2007;2:67-71)
The Release of Elements from Dental Casting Alloy into Cell-Culture Medium and Artificial Saliva
Authors: Can Gülşen , Akpınar Gül , Aydın Ahmet 
Published: September 2019

ABSTRACTObjectives: The biocompatibility of dental casting alloys is a critical issue because these alloys are in long-term intimate contact with oral tissues. Since the biocompatibility of alloys is not completely known; the release of elements from the alloys has been studied. The aim of this study was to compare the elemental release from dental casting alloy during exposure to artificial saliva and cell-culture medium.Materials and Methods: Twenty specimens made from Ni-Cr alloy were provided in the form of 5 mm diameter discs, 2 mm in thickness with a 7 mm stem attached to one face to facilitate handling. Ten of twenty samples were polished separately using a conventional technique. The remaining ten samples were left sandblasted with 50 μm Al203. Ten samples (5 polished, 5 sandblasted) were separately placed into cell-culture wells with Dulbecco’s Modified Eagle’s Medium. The other ten samples were placed separately into cell-culture wells with artificial saliva. The samples were subjected in contact with these medium for 30 days. These medium were collected every 7 days. The cell-culture medium and artificial saliva without alloy samples were subjected to elemental analyses as a control. At the end of the exposure time, Atomic Absorption Spectrometry (AAS) was used to determine the release of elements from the alloys into all collected medium. Statistical analyses were assessed with two-way ANOVAResults: In general, the elemental release occurred with in all medium. The elemental releases of sandblasted alloys were higher than polished alloys. Artificial saliva was found to cause more release from the samples. In both media, Ni released from polished and sandblasted alloys were higher than Cr and Mo.The results suggest that the release of elements from the alloys might have correlated with the environments and the surface of dental alloy. (Eur J Dent 2007;2:86-90)