bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bcl-2 and Ki67 expression in endometrial polyps in postmenopausal women and their association with obesity
Authors: Giordano Mario Vicente , Lucas Hiram da Silveira , Fiorelli Rossano Kepler Alvim , Giordano Luiz Augusto , Gáspare Mario , Júnior José Maria Soares 
Published: August 2019

Abstract
Background: Obesity is a global problem and is associated with numerous diseases, including endometrial disorders in postmenopausal women, such as adenocarcinoma, hyperplasias and endometrial polyps, and with risk of malignant transformation of these structures. We aimed to evaluate the influence of body mass index (BMI) on the cell proliferation markers (Bcl-2 and Ki67) on the endometrial polyps in postmenopause women. Methods: Prospective cross-sectional study using immunohistochemical analysis of the expression of the cell proliferation marker (Ki67) and an anti-apoptotic gene (Bcl-2) in endometrial polyps, in postmenopausal women. The polyps were identified by hysteroscopy and all were removed. The patients were divided into two groups related to BMI: a) BMI <29.9 kg/m2 (normal weight); b) BMI >30 kg/m2 (obese). We analysed the expression of these markers in relation to polyp size, histological type and time since menopause. The interpretation of the Ki67 and Bcl-2 expression data in the endometrial polyps accounted for the percentage of positive cells: score 1 (mild: less than 5% of cells showed expression); score 2 (moderate: between 5 and 50% of cells showed expression); score 3 (severe: more than 50% of cells showed expression). Statistical analysis was performed using the SPSS Statistics program for Windows v23, and the non-parametric Mann-Whitney test was used to analyse the Bcl-2 and Ki67 expression in the glandular and stromal components of the polyps. A significance level of p<0.05 was adopted for rejecting the null hypothesis. Results: There was greater glandular expression of Ki67 in hyperplastic polyps (p=0.04) and greater expression of Bcl-2 in the stroma of polyps larger than 2 cm (p=0.04). No difference in the Ki67 and Bcl-2 expression was found in the glands and stroma of the polyps when compared obese and non-obese postmenopause patients. Conclusion: Our findings suggest that the BMI may not have influence on the proliferation markers (Ki67 and Bcl-2) in the polyps of postmenopausal women.
Appropriate Complementary Feeding Practice and associated factors among mothers with children age 6- 23 months in Faggeta-Lekoma District, Northwest Ethiopia: community- based cross - sectional study
Authors: Ferede Addisu Belete , Bikes Gashaw Andargie , Gebremichael Tsgehana GebreGyorgis 
Published: August 2019

Abstract
Abstract
Objective: the aim of the study was to assess appropriate complementary feeding practices and associated factors among mothers with children of age 6 - 23 months in Faggeta-Lekoma District, Northwest Ethiopia.
Result – A total of 593 study subjects were included in the study. The magnitude of appropriate complementary feeding practice was 10.6%. Majority (67.1%) of the mothers timely initiated complementary feeding at 6 months. About 60% of mothers fulfill the minimum meal frequency feeding to their children, the day preceding the survey. Only 12.3 % mothers offered four or more food groups to their child Mother’s education: high school and above [AOR=3.12(95%CI 1.43, 6.81)], postnatal care visit [AOR=5.30 (95%CI 2.69, 10.42)], Age of a child: 18-23 months [AOR=3.98 (95%CI 1.55, 10.22)] were significantly associated with appropriate complementary feeding practice.
Keywords: appropriate Complementary feeding practice, Children aged 6–23 months, Ethiopia
Skin transcriptome reveals the Periodic changes in genes underlying hair follicle cycling in Cashmere goats
Authors: Liu Zhihong , Yang Feng , Zhao Meng , Mu Qing , Che Tianyu , Xie Yuchun , Ma Lina , Mi Lu , Li Jinquan , Zhao hong Yan 
Published: August 2019

Abstract
Background
Cashmere goats, as an important part of animal husbandry production, make outstanding contributions to animal fiber industry. In recent years, a great deal of research has been done on the molecular regulation mechanism of hair follicle cycle growth. However, there are few reports on the molecular regulation mechanisms of secondary hair follicle growth cycle in cashmere goats. In order to explore the changing regularity of wool follicle cycle and the role of key genes in wool follicle cycle of cashmere goats. we used transcriptome sequencing technique to sequence the skin of Inner Mongolia cashmere goats in different periods, Analyze the variation and difference of genes in the whole hair follicle cycle. And then, we verified the regulation mechanism of cashmere goat secondary hair follicle growth cycle by fluorescence quantitative PCR.

Results

As the result shows: growth period (March-September), regression period (September-December) and resting period (December-March). The results of differential gene analysis showed that March was considered the beginning of the cycle, and the difference of gene expression was the most significant. Cluster analysis of gene expression in the whole growth cycle further supported the key nodes of the three periods of villus growth, and the differential gene expression of keratin corresponding to the villus growth cycle further supported the results of tissue slices. Quantitative fluorescence analysis showed that KAP3-1, KRTAP 8-1 and KRTAP 24-1 genes had close positive correlation with the growth cycle of cashmere, and their regulation was consistent with the growth cycle of cashmere. However, there was a sequence of expression time, indicating that the results of cycle regulation made the growth of cashmere change.

Conclusion

The growth cycle of cashmere hair could be divided into three distinct periods: growth period (March-September), regression period (September-December) and resting period (December-March).March was considered the beginning of the cycle, KAP and KRTAP had close positive correlation with the growth cycle of cashmere, and their regulation was consistent with the growth cycle of cashmere. However, there was a sequence of expression time, indicating that the results of cycle regulation made the growth of cashmere change.
Adaptive evolution of low salinity tolerance and hypoosmotic regulation in a euryhaline teleost, Takifugu obscurus
Authors: Zhang Hanyuan , Hou Jilun , Liu Haijin , Zhu Haoyong , Xu Gangchun , Xu Jian 
Published: August 2019

Abstract
Background: The mechanism of osmoregulation is crucial for maintaining growth, development, and life activities in teleosts. Takifugu obscurus, the only euryhaline species in the genus Takifugu, is a proper model organism for studying the mechanism of low salt-tolerance and hypoosmotic regulation.
Results: In this study, whole genome sequencing data were obtained from 90 pufferfish representing five species within this genus, T. rubripes, T. obscurus, T. flavidus, T. niphobles, and T. bimaculatus. Using a phylogeny, PCA, and population structure analyses, we observed similar amounts of population genetic differentiation among species. The five species are closely related to each other and have differentiated within a relatively short period, while T. bimaculatus and T. flavidus shared the most similar genetic backgrounds. We further identified hundreds of genes under selection related to hypoosmotic regulation between T. obscurus and other Takifugu species, including 16 representative genes involving ion transporters (atp1a3, atp2a2, atp2a3, slc13a1, slc5a8, slc12a2, slc12a4, slc26a2, scn1b, and kcna2/3/10), genes involved in hormone regulation (fyn, prlr, and grb2), and a gene associated with water absorption (aqp3). Conclusions: Our findings provide preliminary insight into the mechanism of osmoregulation and will facilitate follow-up validation of candidate genes related to osmoregulation in T. obscurus.
Ability of Real-time PCR in diagnose Differentiation Various Forms of Cutaneous Leishmaniasis: A Comparative Study with Histopathology
Authors: Abadi Maryam Fekri Soofi , Fekri Meisam , moradabadi alireza , Vahidi Reza , Meymandi Simin Shamsi , Dabiri Donya , dabiri shahriar 
Published: August 2019

Abstract
objective: Histopathological studies suggest that parasite load is different between acute and chronic forms of cutaneous leishmaniasis (CL). However, highly sensitive detection methods are still needed to distinguish different forms of leishmaniasis. In the present study, we developed a quantitative real-time polymerase chain reaction (PCR) to detect and quantify leishmania tropica parasites in paraffin-embedded tissue samples.
Results: The ability of real-time PCR for leishmania detection was higher than histopathological evaluation. The parasite loads were quantified by qPCR assay and microscopic evaluation were highly correlated ( r =0.598; P <0.001). Among patients, the parasite load was inversely correlated with disease duration (acute CL lesions had very higher parasite loads than chronic CL lesions), but there was no difference in parasite load according to the patients’ age and sex as well as location of the lesions. In contrast to Ridley scoring system (P<0.001), there were no statistically significant differences in the relative number of parasites among the lupoid and non-lupoid forms of chronic lesions in real-time PCR (P=0.549), which indicates the superiority of histopathological evaluation in CL forms differentiation.
FACTORS DETERMINING THE QUALITY MANAGEMENT OF HIGHER EDUCATION: A CASE STUDY AT A BUSINESS SCHOOL IN INDONESIA
Authors: Simangunsong Eliot 
Published: August 2019

Despite the facts that higher education institutions are the source of quality concept and theory, they have been lagging behind manufacturing or service businesses in embracing and carrying out proper quality management. Managing quality in higher education is a difficult task due to several factors such as different perspectives between stakeholders and traditional characteristics of institutions. On the other hand, accreditation, for example by the Indonesian Bureau of Higher Education Accreditation, and international accreditation bodies, such as AACSB, EQUIS, is perceived as a tool to demonstrate a certain quality threshold. However, many studies argue that periodic quality assessments using recognized accreditation bodies do not touch inherent quality issues in education, and that they are generally used as an exercise of quality control. The objective of this study is to look beyond quality assessments using these recognized accreditation bodies and examine dimensions of quality from university's stakeholder’s point of view, especially the stakeholder that represents the demand side. Factor analysis is conducted, and the number of factors proposed by the results are identified. There are seven quality dimensions that have impacts on the quality management system in higher education. Three dimensions are new findings, i.e., the importance of providing health and insurance, the importance of good ambiance of campus environment, and stakeholder’s explicit ability to demonstrate quality in higher education.
THE EFFECTIVENESS OF MULTICULTURAL APPROACH IN WRITING ACHIEVEMENT OF INDONESIAN LANGUAGE AMONG ISLAMIC ELEMENTARY SCHOOL STUDENTS
Authors: Alfulaila Noor , Haryadi Haryadi , Sudrajat Ajat , Nashrullah Nashrullah 
Published: August 2019

Multicultural approach in Indonesian language has become an absolute necessity over the last years. This research highlights the role of multicultural culture as a means to improve writing achievement of Indonesian Language among elementary school students. This study aims at determining the effectiveness of the multicultural approach in the writing achievement of Indonesian language among fifth grade students of islamic elementary school who are grouped based on their learning motivation. This study can be catagorized as an experimental study with 2x2 factorial design. The independent variable consists of two categories, multicultural and conventional approaches. The population was 60 fifth grade students of at two private islamic schools. The data was collected using learning achievement tests and learning motivation questionnaires, and analyzed using two-way ANOVA and sheffe test. The results showed that (1) there were a gap in learning achievement between students in the experimental group and control group students; (2) there were differences in learning achievement between students with high motivation between both groups; (3) there were differences in learning achievement between low motivated students between both groups; (4) the multicultural approaches proved to be more effective than the conventional one; and (5) there was no interaction between the approaches and the learning motivation.
TEACHING-LOVING-CARING (ASAH-ASIH-ASUH) AND SEMI-MILITARY EDUCATION ON CHARACTER EDUCATION MANAGEMENT
Authors: Sukendar Asep , Usman Husaini , Jabar Cepi Safrudidin Abdul 
Published: August 2019

Character education for students is important for their future because personal character traits determine the quality of human life. This qualitative study aims to analyze the planning and implementation of character education at Taruna Nusantara Senior High School (SHS), Magelang - a boarding senior high school that combines teaching-loving-caring (asah-asih-asuh) and semi-military education. The unit of analysis consists of individuals and group of subjects directly or indirectly involved in the education process at the researched school and the surrounding, as well as the artifacts. The data are collected through interview, observation, and documentation, and are subsequently analyzed using Huberman and Saldana’s interactive model. The results indicate that, in the planning, the school put more emphasis on three characteristics in character education that characterizes the school: religiosity, morality and leadership. The planning of character education is participatory and integrated. It is implemented in and around the boarding school learning environment. The activities include teaching, training, parenting, and student development.
Feasibility of an Interactive Patient Portal for Monitoring Physical Activity, Remote Symptom Reporting, and Patient Education in Oncology: Qualitative Study
Authors: Marthick Michael , Janssen Anna , Cheema Birinder S , Alison Jennifer , Shaw Tim , Dhillon Haryana 
Published: August 2019

Background
Digital health interventions, such as the use of patient portals, have been shown to offer benefits to a range of patients including those with a diagnosis of cancer.

Objective
This study aimed to explore the participant experience and perception of using an interactive Web-based portal for monitoring physical activity, remote symptom reporting, and delivering educational components.

Methods
Participants who were currently under treatment or had recently completed intensive treatment for cancer were recruited to three cohorts and invited to join a Web-based portal to enhance their physical activity. Cohort 1 received Web portal access and an activity monitor; cohort 2 had additional summative messaging; and cohort 3 had additional personalized health coaching messaging. Following the 10-week intervention, participants were invited to participate in a semistructured interview. Interview recordings were transcribed and evaluated using qualitative thematic analysis.

Results
A total of 17 semistructured interviews were carried out. Participants indicated that using the Web portal was feasible. Personalized messaging improved participant perceptions of the value of the intervention. There was a contrast between cohorts and levels of engagement with increasing health professional contact leading to an increase in engagement. Educational material needs to be tailored to the participants’ cancer treatment status, health literacy, and background.

Conclusions
Participants reported an overall positive experience using the Web portal and that personalized messaging positively impacted on their health behaviors. Future studies should focus more on design of interventions, ensuring appropriate tailoring of information and personalization of behavioral support messaging.

International Registered Report Identifier (IRRID)
RR2-10.2196/9586
HOW TO LEAD THE MILLENNIALS: A REVIEW OF 5 MAJOR LEADERSHIP THEORY GROUPS
Authors: Putriastuti Bernadeta Cahya Kumala , Stasi Alessandro 
Published: August 2019

Millennials are currently taking over the global workforce. While practitioners and scholars have recognized their different work values from previous generations, research on this topic is still scarce. Furthermore, the current leadership theories have tended to focus mainly on the characteristics of leaders without adequately examining the leadership styles that work best for the millennials. Using a literature review from the top tier leadership journals, this paper aims to provide a more comprehensive framework to provide new directions for the development of leadership theory by understanding the millennials’ perspective on leadership. This study thus contributes to the current literatures by using five thematic leadership groups to develop the most optimum leadership style for leading the Millennials. The advantages and disadvantages of using neo-charismatics, leadership and information processing, social exchange/relational leadership, ethical/moral leadership, and e-leadership theories in leading millennials are assessed. Results show that no single leadership theory is adequate for leading the millennials optimally. Hence, mixing the dimensions of different leadership theory groups is suggested. As for the leadership theory aspects, it is recommended to scholars to consider developing more flexible leadership theory models that can accommodate different generational groups.
Alessia Frassani, Artistas, mecenas y feligreses en Yanhuitlán, Mixteca Alta, siglos XVI-XXI
Authors: Gamboa M. Jorge Augusto 
Published: August 2019

Reseña sobre Alessia Frassani, <em>Artistas, mecenas y feligreses en Yanhuitlán, Mixteca Alta, siglos XVI-XXI.</em> México/Bogotá: Universidad Autónoma de México/Universidad de los Andes, 2017.
PRINCIPAIS COMPLICAÇÕES DA CIRCULAÇÃO EXTRACORPÓREA EM CIRURGIAS CARDÍACAS EM UM HOSPITAL DA REGIÃO NORTE
Authors: Barros Sandy Ribeiro , Bandeira Michele Matias , Leite Jandra Cibele Rodrigues de Abrantes Pereira 
Published: August 2019

Jonh Gibbon é o pai da Circulação Extracorpórea (CEC) e desde 1953 vários estudos vêm sendo realizados com o objetivo de diminuir a morbimortalidade desse procedimento, já que o perfil de pacientes vem mudando com a realização de cirurgias em pacientes mais idosos e acompanhados de várias comorbidades. O objetivo da pesquisa é analisar as principais complicações em pacientes submetidos a cirurgias cardíacas utilizando a circulação extracorpórea. Trata-se de uma pesquisa quantitativa e descritiva, realizada no hospital Dr. Ary Pinheiro em Porto Velho-RO, sendo analisados 16 prontuários de pacientes que realizaram cirurgia cardíaca utilizando a CEC no período de janeiro 2016 a dezembro de 2017. Dentre as complicações encontradas no pós-operatório a algia acometeu 9 (56,3%), a hipotensão e leucocitose ambas em 8 (50,0%), arritmia/taquicardia 5 (31,3%), estes com mais frequência, tendo a ocorrência de 3 (18,8%) óbitos. Para a equipe de enfermagem, o conhecimento das complicações no pós-operatório de cirurgia cardíaca com o uso da CEC facilita a implementação de um plano de cuidados adequado, prevenindo maiores complicações, sequelas e até mesmo óbitos.
KARAKTERISTIK KEPAILITAN BADAN HUKUM KOPERASI
Authors: Suharto Rachmat 
Published: August 2019

This study aims to determine the construction of bankruptcy law associated with the characteristics of cooperative legal entities. The approach used is a statutory approach, a conceptual approach, and a case approach. The source of legal material consists of primary legal material and secondary legal material.The results of the study show that cooperative legal entities are activities carried out by a group of people or groups that prioritize family-based activities, cooperation, mutual cooperation based on equality, rights and obligations to achieve common goals, namely the welfare of all members cooperatives This is what gives birth to two dimensions of cooperatives, namely the social dimension and the economic dimension namely achieving prosperity through cooperation and mutual cooperation that works based on the ideal foundation, structural foundation and operational foundation. In the event of bankruptcy, the filing of cooperative bankruptcy should be carried out by the Ministry of Cooperatives after the efforts of guidance and supervision by the Ministry of Cooperatives.
Doença de Parkinson: representação material da vulnerabilidade humana no contexto do cuidador familiar
Authors: Reis Rogério Donizeti , Batista Marcos Antônio , Silva José Vitor da 
Published: August 2019

A Doença de Parkinson (DP) é a segunda doença neurodegenerativa mais comum. Na DP a forma degenerativa ou idiopática é a mais encontrada; existe também uma forma secundária com causa conhecida ou suspeita. Clinicamente, a DP manifesta-se com bradicinesia, rigidez, tremor de repouso e instabilidade postural. O início da DP é de caráter assimétrico e insidioso. A evolução dos sintomas é usualmente lenta e o prognóstico clínico é muito variável. O impacto da DP afeta todos os membros da família, pois além dos aspectos financeiros, toda organização familiar, psicológica e social sofre alterações. Tal fato representa desafio aos enfermeiros e gestores das políticas sociais e de saúde, pois as pessoas com DP e seus familiares carecem de atenção e cuidados por um longo período de tempo (ALVAREZ et al., 2016). Pensar no cuidador familia é pensar também em um contexto de vulnerabilidade. É provável que quanto maior for a situação de vulnerabilidade deste cuidador, quanto maior for a falta de conhecimento das condições de saúde por parte dele ou da família, maior será o grau e/ou intensidade da vulnerabilidade (SILVA, 2017). Objetivo: Conhecer o sentimento do cuidador informal primário quanto aos cuidados e o convívio com membro familiar com Doença de Parkinson.
Estigma: um desafio ético para a consolidação das políticas públicas de combate ao HIV no Brasil
Authors: Fernandes Sarah Abdon Lacerda  , Costa Thaís Albuquerque da , Reis Bianca Izabella Carvalho dos , Sarsur Marcelo , Dadalto Lucina 
Published: August 2019

Desde 1982, quando os primeiros casos de SIDA (Síndrome da Imunodeficiência Adquirida) surgiram no Brasil, foram atribuídas, cientificamente e socialmente, diversas características aos portadores do HIV. Inicialmente, essa foi uma consequência natural, afinal, tratava-se de uma doença desconhecida, incurável, disseminada mundialmente, famosa por causar a morte de diversas pessoas e sem controle, o que a colaborava para a reprodução dos estigmas. Sabe-se que o Brasil possui uma das melhores respostas públicas à epidemia do HIV no mundo e recebe apoio de diversos países, entidades e organismos internacionais., entretanto, dados do Relatório de Monitoramento Clínico do HIV realizado em 2016 demonstra que o estigma continua presente na sociedade brasileira: em 2016, eram cerca de 830.000 pessoas vivendo com o vírus no país, destes, somente 60% buscavam acesso ao tratamento antirretroviral. Nesse contexto, o presente trabalho de bioética social, por meio de pesquisa teórica de natureza exploratória com levantamento bibliográfico e documental, busca confrontar o estigma com as legislações e políticas públicas de combate e prevenção do HIV no Brasil. Já se passaram mais de trinta e cinco anos desde os primeiros casos e nesse tempo foram criadas diversas políticas públicas, entre elas está a política de acesso ao tratamento integral gratuito, a de assistência, a do diagnóstico adequado, a do direito ao sigilo e a da prevenção ao HIV.