bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical performance of intentionally tilted implants versus axially positioned implants: A systematic review
Authors: Lin Wei‐Shao , Eckert Steven E. 
Published: October 2018

AbstractObjectivesThe aim of this review was to determine the clinical performance of dental implants that are intentionally tilted when compared with implants that are placed following the long axis of the residual alveolar ridge.Materials and methodsA systematic review of the scientific literature using a predefined research question (PICO) and search strategy was undertaken. This search included five electronic databases. Two independent reviewers examined electronic databases and performed a manual review following search strategy to accomplish the item generation and reduction. Included articles were evaluated to determine the level of evidence. Data were extracted only from level I and level II studies, based on the Oxford Centre for Evidence‐based Medicine—Levels of Evidence (March 2009). If included studies were homogeneous in nature, data were to be accumulated. However, if included studies were heterogeneous in nature, only descriptive data would be reviewed and analyzed.ResultsA total of 811 articles were identified through the PICO question and search strategy. Detailed review of the abstracts and articles resulted in further item reduction, and 46 articles were included for full‐text review. A total of 42 articles were then selected for inclusion in the systematic review. The identified articles included two level I and 20 level II studies. In addition, 15 level IV, one gray literature, and four previous systematic reviews with meta‐analyses were also used in the study. The extracted data from the included studies demonstrated heterogeneity that prevented quantitative assessment, and only one level II study directly compared tilted and axially placed implants. Assessment of the descriptive data demonstrated no differences in implant survival, marginal bone loss, prosthesis survival, or patient‐reported outcome measures (PROMs) whether implants are placed axially or with intentional inclination of the coronal aspect of the implant toward the distal aspect of edentulous jaws.ConclusionsBased upon the systematic review of the literature, an analysis of the descriptive data suggested no differences in clinical performance between implants that are placed in an axial position relative to the residual alveolar ridge when compared with implants that are intentionally tilted toward the distal aspect of edentulous jaws.
Group 2 ITI Consensus Report: Prosthodontics and implant dentistry
Authors: Morton Dean , Gallucci German , Lin Wei‐Shao , Pjetursson Bjarni , Polido Waldemar , Roehling Stefan , Sailer Irena , Aghaloo Tara , Albera Hugo , Bohner Lauren , Braut Vedrana , Buser Daniel , Chen Stephen , Dawson Anthony , Eckert Steven , Gahlert Michael , Hamilton Adam , Jaffin Robert , Jarry Christian , Karayazgan Banu , Laine Juhani , Martin William , Rahman Lira , Schlegel Andreas , Shiota Makato , Stilwell Charlotte , Vorster Christiaan , Zembic Anja , Zhou Wenjie 
Published: October 2018

AbstractObjectivesWorking Group 2 was convened to address topics relevant to prosthodontics and dental implants. Systematic reviews were developed according to focused questions addressing (a) the number of implants required to support fixed full‐arch restorations, (b) the influence of intentionally tilted implants compared to axial positioned implants when supporting fixed dental prostheses (FDPs), (c) implant placement and loading protocols, (d) zirconia dental implants, (e) zirconia and metal ceramic implant supported single crowns and (f) zirconia and metal ceramic implant supported FDPs.Materials and methodsGroup 2 considered and discussed information gathered in six systematic reviews. Group participants discussed statements developed by the authors and developed consensus. The group developed and found consensus for clinical recommendations based on both the statements and the experience of the group. The consensus statements and clinical recommendations were presented to the plenary (gathering of all conference attendees) and discussed. Final versions were developed after consensus was reached.ResultsA total of 27 consensus statements were developed from the systematic reviews. Additionally, the group developed 24 clinical recommendations based on the combined expertise of the participants and the developed consensus statements.ConclusionsThe literature supports the use of various implant numbers to support full‐arch fixed prostheses. The use of intentionally tilted dental implants is indicated when appropriate conditions exist. Implant placement and loading protocols should be considered together when planning and treating patients. One‐piece zirconia dental implants can be recommended when appropriate clinical conditions exist although two‐piece zirconia implants should be used with caution as a result of insufficient data. Clinical performance of zirconia and metal ceramic single implant supported crowns is similar and each demonstrates significant, though different, complications. Zirconia ceramic FDPs are less reliable than metal ceramic. Implant supported monolithic zirconia prostheses may be a future option with more supporting evidence.
A systematic review of the survival and complication rates of zirconia‐ceramic and metal‐ceramic single crowns
Authors: Pjetursson Bjarni E , Valente Nicola A , Strasding Malin , Zwahlen Marcel , Liu Shiming , Sailer Irena 
Published: October 2018

AbstractObjectivesThe aim of the present systematic review was to analyze the survival and complication rates of zirconia‐based and metal‐ceramic implant‐supported single crowns (SCs).Materials and MethodsAn electronic MEDLINE search complemented by manual searching was conducted to identify randomized controlled clinical trials, prospective cohort and retrospective case series on implant‐supported SCs with a mean follow‐up time of at least 3 years. Patients had to have been clinically examined at the follow‐up visit. Assessment of the identified studies and data extraction was performed independently by two reviewers. Failure and complication rates were analyzed using robust Poisson's regression models to obtain summary estimates of 5‐year proportions.ResultsThe search provided 5,263 titles and 455 abstracts, full‐text analysis was performed for 240 articles, resulting in 35 included studies on implant‐supported crowns. Meta‐analysis revealed an estimated 5‐year survival rate of 98.3% (95% CI: 96.8–99.1) for metal‐ceramic implant supported SCs (n = 4,363) compared to 97.6% (95% CI: 94.3–99.0) for zirconia implant supported SCs (n = 912). About 86.7% (95% CI: 80.7–91.0) of the metal‐ceramic SCs (n = 1,300) experienced no biological/technical complications over the entire observation period. The corresponding rate for zirconia SCs (n = 76) was 83.8% (95% CI: 61.6–93.8). The biologic outcomes of the two types of crowns were similar; yet, zirconia SCs exhibited less aesthetic complications than metal‐ceramics. The 5‐year incidence of chipping of the veneering ceramic was similar between the material groups (2.9% metal‐ceramic, 2.8% zirconia‐ceramic). Significantly (p = 0.001), more zirconia‐ceramic implant SCs failed due to material fractures (2.1% vs. 0.2% metal‐ceramic implant SCs). No studies on newer types of monolithic zirconia SCs fulfilled the simple inclusion criteria of 3 years follow‐up time and clinical examination of the present systematic review.ConclusionZirconia‐ceramic implant‐supported SCs are a valid treatment alternative to metal‐ceramic SCs, with similar incidence of biological complications and less aesthetic problems. The amount of ceramic chipping was similar between the material groups; yet, significantly more zirconia crowns failed due to material fractures.
Group 4 ITI Consensus Report: Risks and biologic complications associated with implant dentistry
Authors: Heitz‐Mayfield Lisa J. , Aaboe Merete , Araujo Mauricio , Carrión Juan B. , Cavalcanti Raffaele , Cionca Norbert , Cochran David , Darby Ivan , Funakoshi Eiji , Gierthmuehlen Petra C. , Hashim Dena , Jahangiri Leila , Kwon Yongdae , Lambert France , Layton Danielle M. , Lorenzana Eduardo R. , McKenna Gerald , Mombelli Andrea , Müller Frauke , Roccuzzo Mario , Salvi Giovanni E. , Schimmel Martin , Srinivasan Murali , Tomasi Cristiano , Yeo Alvin 
Published: October 2018

AbstractObjectivesThe aim of Working Group 4 was to address topics related to biologic risks and complications associated with implant dentistry. Focused questions on (a) diagnosis of peri‐implantitis, (b) complications associated with implants in augmented sites, (c) outcomes following treatment of peri‐implantitis, and (d) implant therapy in geriatric patients and/or patients with systemic diseases were addressed.Materials and methodsFour systematic reviews formed the basis for discussion in Group 4. Participants developed statements and recommendations determined by group consensus based on the findings of the systematic reviews. These were then presented and accepted following further discussion and modifications as required by the plenary.ResultsBleeding on probing (BOP) alone is insufficient for the diagnosis of peri‐implantitis. The positive predictive value of BOP alone for the diagnosis of peri‐implantitis varies and is dependent on the prevalence of peri‐implantitis within the population. For patients with implants in augmented sites, the prevalence of peri‐implantitis and implant loss is low over the medium to long term. Peri‐implantitis treatment protocols which include individualized supportive care result in high survival of implants after 5 years with about three‐quarters of implants still present. Advanced age alone is not a contraindication for implant therapy. Implant placement in patients with cancer receiving high‐dose antiresorptive therapy is contraindicated due to the associated high risk for complications.ConclusionsDiagnosis of peri‐implantitis requires the presence of BOP as well as progressive bone loss. Prevalence of peri‐implantitis for implants in augmented sites is low. Peri‐implantitis treatment should be followed by individualized supportive care. Implant therapy for geriatric patients is not contraindicated; however, comorbidities and autonomy should be considered.
The accuracy of static computer‐aided implant surgery: A systematic review and meta‐analysis
Authors: Tahmaseb Ali , Wu Vivian , Wismeijer Daniel , Coucke Wim , Evans Christopher 
Published: October 2018

AbstractObjectivesTo assess the literature on the accuracy of static computer‐assisted implant surgery in implant dentistry.Materials and MethodsElectronic and manual literature searches were conducted to collect information about the accuracy of static computer‐assisted implant systems. Meta‐regression analysis was performed to summarise the accuracy studies.ResultsFrom a total of 372 articles. 20 studies, one randomised controlled trial (RCT), eight uncontrolled retrospective studies and 11 uncontrolled prospective studies were selected for inclusion for qualitative synthesis. A total of 2,238 implants in 471 patients that had been placed using static guides were available for review. The meta‐analysis of the accuracy (20 clinical) revealed a total mean error of 1.2 mm (1.04 mm to 1.44 mm) at the entry point, 1.4 mm (1.28 mm to 1.58 mm) at the apical point and deviation of 3.5°(3.0° to 3.96°). There was a significant difference in accuracy in favour of partial edentulous comparing to full edentulous cases.ConclusionDifferent levels of quantity and quality of evidence were available for static computer‐aided implant surgery (s‐CAIS). Based on the present systematic review and its limitations, it can be concluded that the accuracy of static computer‐aided implant surgery is within the clinically acceptable range in the majority of clinical situations. However, a safety marge of at least 2 mm should be respected. A lack of homogeneity was found in techniques adopted between the different authors and the general study designs.
Performance and outcome of zirconia dental implants in clinical studies: A meta‐analysis
Authors: Roehling Stefan , Schlegel Karl A. , Woelfler Henriette , Gahlert Michael 
Published: October 2018

AbstractObjectivesTo evaluate implant survival, peri‐implant marginal bone loss, technical, and biological complications as well as aesthetic outcomes of zirconia implants in clinical studies.Material and MethodsElectronic (Medline, Embase) and hand searches were performed to identify clinical studies published between January 2004 and March 2017 investigating zirconia dental implants with a mean follow‐up of at least 12 months. Primary outcomes were implant survival and peri‐implant marginal bone loss. Secondary outcomes included technical and biological complications as well as aesthetic outcomes. Meta‐analyses were performed to estimate implant survival and marginal bone loss.ResultsFrom 943 titles, 264 abstracts were selected. Subsequently, 80 full‐text articles were screened, and 18 studies were included for data extraction. One‐ (14 studies) and 2‐piece zirconia implants (4 studies) were investigated. Commercially available (CA) (510 implants, 398 patients) and not commercially available (NCA) zirconia implants (618 implants, 343 patients) were identified. For CA implants (follow‐up: 12–61.20 months), technical complications (1.6%), implant fractures (0.2%) and biological complications (4.2%) were reported. Meta‐analyses estimated 1‐ and 2‐year survival rates of 98.3% (95% CI: 97.0%–99.6%) and 97.2% (95% CI: 94.7%–99.7%), respectively, and a mean 1‐year marginal bone loss of 0.7 mm (95% CI: 0.4–1.0 mm).ConclusionsSince 2004, the survival rates of CA implants significantly improved compared with NCA implants. CA 1‐piece zirconia implants showed similar 1‐ and 2‐year mean survival rates and marginal bone loss after 1 year compared with published data for titanium implants. However, more clinical long‐term data are needed to confirm the presently evaluated promising short‐term outcomes.
Is C‐11 Methionine PET an alternative to 18‐F FDG‐PET for identifying recurrent laryngeal cancer after radiotherapy?
Authors: Wedman Jan , Pruim Jan , van der Putten Lisa , Hoekstra Otto S. , de Bree Remco , van Dijk Boukje A. C. , van der Laan Bernard F. A. M. 
Published: October 2018

Objective18F FDG‐PET is superior to other imaging techniques in revealing residual laryngeal cancer after radiotherapy. Unfortunately, its specificity is low, due to FDG uptake in inflammation and in anaerobic conditions. PET imaging with the amino acid‐based radiopharmaceutical C11‐methionine (MET) should be less influenced by post‐radiation conditions. The aim of this study was to investigate the potential of MET in diagnosing recurrent laryngeal cancer after radiotherapy as compared to 18F‐FDG.MethodsForty‐eight patients with a clinical suspicion of local residual disease at least 3 months after completion of radiotherapy or chemoradiotherapy for a T2‐4 laryngeal carcinoma, along with an indication for direct laryngoscopy, were included. They received MET‐PET and FDG‐PET prior to the direct laryngoscopy. One senior nuclear medicine physician assessed both the FDG‐PET and MET‐PET images visually for the degree of abnormal uptake. The gold standard was a biopsy‐proven recurrence 12 months after PET. The nuclear physician had no access to the medical charts and was blinded to the results of the other PET. Sensitivity, specificity and positive and negative predictive value were calculated.ResultsThe sensitivity of FDG was 77.3% and the specificity 56.0% after the conservative reading, with these values equalling 54.5% and 76.0% for MET. The positive predictive value of FDG was 60.7% and the negative predictive value 73.7%. The PPV of MET was 66.7%, and the NPV was 65.5%. The McNemar test within diseased (sensitivity comparison) shows a p‐value of 0.125, and the McNemar test within non‐diseased (specificity comparison) shows a P‐value of 0.180.ConclusionMET‐PET is not superior to FDG‐PET in terms of identifying recurrent laryngeal cancer.
Zyxin‐involved actin regulation is essential in the maintenance of vinculin focal adhesion and chondrocyte differentiation status
Authors: Li Gaoming , Song Xiongbo , Li Rui , Sun Li , Gong Xiaoyuan , Chen Cheng , Yang Liu 
Published: October 2018

AbstractObjectivesTo investigate the role of zyxin‐involved actin regulation in expression level of vinculin focal adhesion and collagen production of chondrocyte and its possible underlying mechanism.Materials and methodsChondrocytes obtained from rabbit articular cartilage were used in this study. The expression of zyxin, actin and vinculin, as well as the extracellular matrix (ECM) protein collagen type I, II and X (COL I, II and X) of chondrocytes were compared between zyxin‐knockdown group and negative control group, and between transforming growth factor‐β1 (TGF‐β1) treatment group and non‐treatment group, respectively.ResultsKnockdown of zyxin increased the ratio of globular actin (G‐actin) to filamentous actin (F‐actin) of chondrocyte, which further inhibited expression of vinculin and chondrogenic marker COL II as well as hypertrophy marker COL X. On the other hand, chondrocytes treated with TGF‐β1 showed an enhanced expression of F‐actin, and a lower expression of zyxin compared to non‐treatment group. In response to TGF‐β1‐induced actin polymerization, expression of vinculin and COL I was increased, while expression of COL II and aggrecan was decreased.ConclusionsThese results demonstrate supporting evidence that in chondrocytes the level of zyxin is closely associated with the state of actin polymerization. In particular, the change of zyxin and F‐actin parallels with the change of COL II and vinculin, respectively, indicating a major role of zyxin‐actin interaction in the synthesis of collagen ECM and the remodelling of cytoskeleton‐ECM adhesion.
Outcomes for potential kidney transplant recipients offered public health service increased risk kidneys: A single‐center experience
Authors: Fernandez Hilda E. , Chiles Mariana C. , Pereira Marcus , Husain Syed Ali , Miko Benjamin , Baral Prativa , Dale Leigh‐Anne , Patel Shefali , Runge Brian , Tsapepas Demetra , Sandoval Pedro Rodrigo , Ratner Lloyd E. , Cohen David J. , Mohan Sumit 
Published: October 2018

AbstractBackgroundDiscard rate of Public Health Service Increased Risk (PHS‐IR) organs is high despite the absence of worse kidney transplant outcomes.MethodsWe conducted a retrospective, single‐center study of PHS‐IR kidney offers made to kidney transplant‐only potential recipients from 6/2004 to 5/2015. Overall mortality and transplant outcomes between potential recipients were stratified by response to PHS‐IR kidney offers. Cox regression and Kaplan‐Meier analyses of mortality and allograft failure were performed.ResultsA total of 2423 potential recipients were offered a PHS‐IR kidney, with 1502 transplanted, with or without a PHS‐IR kidney. Predictors of accepting a PHS‐IR kidney included higher Estimated Post Transplant Survival (EPTS) score, prior kidney transplant, and lower educational achievement on multivariable analysis (P = 0.025, P = 0.004, P = 0.023). A positive response to a PHS‐IR kidney was associated with lower risk of mortality (3.63% vs 11.6%; aHR 0.467, P = 0.0008). PHS‐IR kidney recipients had decreased risk of allograft loss compared to non‐PHS‐IR recipients (P = 0.007), though mortality outcomes were not significantly different based on PHS‐IR status (P = 0.38). No transmission of HIV, HBV, or HCV occurred from PHS‐IR kidney donors in this cohort.ConclusionsEfforts must be made to increase awareness of the beneficial outcomes of PHS‐IR organs to maximize appropriate donor allocation.
The expression of terminal deoxynucleotidyl transferase and paired box gene 5 in Merkel cell carcinomas and its relation to the presence of Merkel cell polyomavirus DNA
Authors: Johansson Benjamin , Sahi Helka , Koljonen Virve , Böhling Tom 
Published: October 2018

BackgroundMerkel cell carcinoma (MCC) tumor samples frequently express B‐lymphoid lineage markers. However, the reasons for expression of specific B‐lymphoid lineage markers are still unclear. We studied the expression of TdT and PAX5 (two B‐cell lymphoid lineage markers) in a large pool of MCC tissue microarray samples.MethodsImmunoexpression and staining intensities of TdT and Pax‐5 were statistically correlated with patient, tumor, Merkel cell polyomavirus (MCV), and disease‐specific parameters.ResultsIn a cohort of 117 MCC patients and their corresponding tumor samples, TdT was expressed in 37 (31.6%) samples and PAX5 in 26 (22.2%). Simultaneous immunostaining for TdT and PAX5 was observed in 13 (11.1%) samples. A statistically significant relationship was observed between MCV virus copy number and positive TdT expression (P = 0.0056). Similarly, a significant relationship was also observed between positive TdT and tumor MCV virus positivity (P = 0.000495).ConclusionWe observed frequent TdT and PAX5 immunoexpression in MCC tumor samples. However, simultaneous immunoexpression of these markers was scarce. TdT expression was statistically significantly associated with MCV positivity. The absence of a statistically significant association between tumor parameters and disease progression markers undermines the systemic use of these markers in clinical practice.
Meta‐analysis of neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratio in rheumatoid arthritis
Authors: Erre Gian Luca , Paliogiannis Panagiotis , Castagna Floriana , Mangoni Arduino Aleksander , Carru Ciriaco , Passiu Giuseppe , Zinellu Angelo 
Published: October 2018

AbstractBackgroundWe conducted a meta‐analysis to review the available evidence regarding the associations between peripheral blood neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) and the presence of rheumatoid arthritis (RA).MethodsPubMed, Web of Science and Scopus, from inception to January 2018, were searched for studies reporting on NLR and PLR in RA in comparison with healthy subjects. Standardized mean difference (SMD) was calculated with a confidence interval (CI) of 95%.ResultsThirteen NLR studies (1550 RA patients and 1128 healthy controls) and 8 PLR studies (380 RA patients and 305 healthy controls) were included in the meta‐analysis. NLR and PLR were significantly higher in patients with RA when compared to controls (SMD = 0.79, 95% CI 0.55‐1.03; P < 0.001 and SMD = 0.66, 95% CI 0.43‐0.88; P < 0.001, respectively).ConclusionsThe NLR and PLR are significantly associated with the presence of RA. Further studies are required to ascertain the potential clinical use of these simple and relatively inexpensive markers in RA diagnosis.