bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Investigation of the Role of Benzopyran Dihydropyrimidinone Hybrids in Cell Proliferation, Migration and Tumor Growth
Authors: Dash Ashutosh K. , Nayak Debasis , Hussain Nazar , Mintoo Mubashir J. , Bano Sumera , Katoch Archana , Mondhe Dilip M. , Goswami Anindya , Mukherjee Debaraj 
Published: September 2018

Background:Cancer is the second leading cause of mortality worldwide after heart diseases, and lung cancer is the topmost cause of all cancer-related deaths in both sexes. Dihydropyrimidinones (DHPMs) are medicinally important class of molecules with diverse pharmacological activities including anticancer activity. The present study focuses on the molecular hybridization of novel Benzopyran with Dihydropyrimidinone and evaluation of the resulting hybrids for cancer cell proliferation, migration and tumor growth.Methods:We have synthesized a focused library of dihydropyrimidinone benzopyran hybrids (compounds 1-11) by joining the aromatic as well as pyran portions of the benzopyran core with dihydropyrimidinone. All the synthesized hybrid molecules were evaluated for their cytotoxic activities against a panel of four human cancer cell lines of diverse tissue origin, viz: A549 (lung carcinoma), MCF7 (mammary gland adenocarcinoma), HCT-116 (colorectal carcinoma), and PANC-1 (pancreatic duct carcinoma) with the help of MTT cell viability assay. A structure-activity relationship was made on the basis of IC50 values of different hybrids. Effect on cell proliferation was examined through colony formation assay, reactive oxygen species generation and mitochondrial membrane potential studies. Wound healing assays and cell scattering assays were employed to check the effect on cell migration. Western blotting experiments were performed to find out the molecular mechanism of action and anti-tumor studies were carried out to evaluate the in vivo efficacy of the selected lead molecule.Results:Two types of novel hybrids were synthesized efficiently from benzopyran aldehydes, ethylacetoacetate and urea under heteropolyacid catalysis. Compound 3 was found to be the most potent hybrid among the synthesized compounds with consistent cytotoxic activities against four human cancer cell lines (IC50 values: 0.139 - 2.32 μM). Compound 3 strongly inhibited proliferation abilities of A549 cells in colony formation assay. Compound 3 exerted oxidative stress-mediated mitochondrial dysfunction, in which mitochondrial reactive oxygen species (ROS) generation as a mechanism of its anti-proliferative effects was analysed. Further, the molecule abrogated migration and cell scattering properties of aggressive PANC-1 cells. Mechanistic studies revealed that compound 3 modulated NF-kB expression and its downstream oncogenic proteins involved in cancer cell proliferation and invasion. Finally, compound 3 confirmed its in vivo anti-tumor efficacy; there observed 41.87% tumor growth inhibition at a dose of 30 mg/kg/body weight against a mouse model of Ehrlich solid tumor.Conclusion:Our study unravels a potential anticancer lead (compound 3) from DHPMs that have opened up new research avenues for the development of promising anticancer therapeutic agents.
Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus
Authors: Hartmann Lisandra Torres , Alegretti Ana Paula , Machado Alice Beatriz Mombach Pinheiro , Martins Eduardo Ferreira , Silva Chakr Rafael Mendonça da , Gasparin Andrese Aline , Monticielo Odirlei André 
Published: September 2018

Introduction:
The Mean Platelet Volume (MPV) is a platelet activation biomarker that has been recently correlated with disease activity in SLE. We aimed to evaluate the MPV in patients with SLE comparing it with healthy individuals, to study the correlation between MPV and SLE Disease Activity Index (SLEDAI) in SLE patients and to analyze possible correlation between MPV and Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), and complement components C3 and C4.

Methods:
This is a cross-sectional study in which 81 patients with SLE according to the American College of Rheumatology (ACR) diagnostic classification criteria and 58 healthy controls were included. Active disease was defined as SLEDAI>0.

Results:
Patients with active SLE had decreased MPV when compared to inactive disease group (10.0±0.7fL vs. 10.7±1.0fL, p=0.005, respectively) and when compared to control group (10.9±1.0fL, p<0.001). Our study found a weak negative correlation between the SLEDAI and the MPV (r=-0.29, p=0.009). There was no correlation between MPV and CRP, ESR, C3 and C4. Also, no correlation between SLEDAI and CRP, ESR, C3 and C4 was found.

Conclusion:

MPV decreases in patients with active SLE and is inversely correlated with SLEDAI.
Visit to an Unknown City: Exploring Children’s Fictional Narratives About a Tourist Experience
Authors: Della Croce Roberta , Elmi Benedetta , Fioretti Chiara , Smorti Andrea 
Published: September 2018

Background:Children have an important role in the decision making process about travels. However, research about children in tourism is still lacking. Although scholars have investigated memories of trips, imagination and expectations on visiting new places that have not yet been explored.Objective:To explore children’s narratives about visiting an unknown city.Methods:Fifty-nine third grade 7-to-8-year-old children took part in the study. Children were asked to write a story on the visit to an unknown city starting from a given stem.Results:Two types of stories emerged from children’s narrations: likelihood and non-likelihood stories. The latter were characterized by the presence of complicating actions and resolutions, villain characters, fight and achievement and were rich in typical elements of fairy tale story. Likelihood stories were characterized by the presence of play and exploration activities, parents characters and the return to home. These type of stories mainly lack complicating action, resolutions and verbal interactions. Finally, these narrations do not show dramatic features as fantasy stories. The lexical analysis of emotions revealed that non-likelihood stories show more negative affective words than likelihood ones.Conclusion:Results make an important contribution to research on children’s narratives about travel, highlighting children’s imagination and expectations on the travel experience and providing an analysis of their representations.
Prevalence of Subclinical Amyloidosis in a Cross-sectional Study of Egyptian RA Patients without Proteinuria
Authors: Bassiouni Hassan , El-Atrebi Ahmed , Zaky Khaled , Abou-Gabal Hoda 
Published: September 2018

Background:
Amyloidosis is a life-threatening complication of Rheumatoid Arthritis
(RA) that should be detected as early as possible to avoid its morbidity and mortality.

Objective:
To detect subclinical amyloidosis in RA patients without proteinuria and a disease duration
more than 5 years.

Patients:
Eighty-six RA patients seen between October 2013 and August 2014 were recruited for
the study. Those with 5 years disease duration were included in the study but those who had proteinuria,
serum creatinine > 1.5 mg/dl, disease onset before the age of 16 years or improper specimens,
were excluded, leaving 30 eligible patients (23 women, 7 men). The clinical, laboratory and
imaging results and treatments were maintained for each patient. Abdominal Fat Aspiration Biopsy
(AFAB) was performed on all 30 patients. Amyloid deposits were spotted by polarised light microscopy
following Congo red staining. Informed consent was acquired from all patients. Clinical
disease activity was scored according to DAS. ELISA measured serum amyloid A protein (SAA),
CRP and RF.

Results:
AFAB stained positive for amyloid in 4 (13.3%) patients out of 30. The amyloid deposits
were (1+) in 1 patient and (2+) in 3 patients. Longer RA duration correlated positively with amyloidosis
(12.50 years versus 6.15years) (P < 0.001). Extra-articular manifestations were present in
50% of the amyloid patients and in 15.3% of the non-amyloid patients. This difference was significant
(P < 0.01). DAS 28 score was higher in amyloid patients (P < 0.001). No difference was found
between amyloid and non-amyloid patients regarding age, sex or deformities. SAA was significantly
higher in amyloid patients (P < 0.001). However, haemoglobin levels were found to be significantly
lower in amyloid patients (P < 0.001).

Conclusion:
The prevalence of subclinical amyloidosis by AFAB was found to be (13.3%). The
use of AFAB should be encouraged, particularly in patients with longer disease duration and low
haemoglobin level to confirm early detection of subclinical amyloidosis.
The influencing factors of self directed learning readiness and academic achievement
Authors: Ramli Nurjannah , Muljono Pudji , Afendi Farit M 
Published: September 2018

FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP SELF DIRECTED LEARNING READINESS DAN PRESTASI AKADEMIKAbstrakPenelitian ini bertujuan untuk menganalisis pengaruh karakteristik mahasiswa, faktor internal, dan faktor eksternal terhadap self directed learning readiness (SDLR) dan prestasi akademik mahasiswa serta menganalisis pengaruh SDLR terhadap prestasi akademik mahasiswa. Penelitian dilakukan dengan menggunakan desain survei terhadap 111 mahasiswa tahun ke-IV Program Studi Sarjana Kedokteran Universitas Tadulako dengan menggunakan instrumen berupa kuesioner untuk mengukur faktor internal, faktor eksternal, dan SDLR. Indeks prestasi kumulatif (IPK) mahasiswa digunakan untuk mengukur prestasi akademik. Data dianalisis secara kuantitatif dengan menggunakan alat bantu analisis Structural Equation Modeling (SEM) dengan metode alternatif berbasis variance atau component based SEM yang disebut Partial Least Square (PLS). Hasil penelitian menunjukkan bahwa karakteristik mahasiswa dan faktor internal berpengaruh secara signifikan terhadap SDLR dan prestasi akademik mahasiswa, sedangkan faktor eksternal tidak berpengaruh terhadap SDLR dan prestasi akademik mahasiswa. Faktor yang memberikan pengaruh yang lebih tinggi terhadap SDLR dan prestasi akademik mahasiswa adalah faktor internal. Hasil penelitian juga menunjukkan bahwa SDLR tidak berpengaruh terhadap pencapaian prestasi akademik mahasiswa. AbstractThis study was aimed at analyzing the influence factors of student characteristics, the internal factors, and external factors of self-directed learning readiness (SDLR) and student academic achievement as well as the influence factors of SDLR on student academic achievement. This study was conducted by using a survey design on 111 students of the fourth year of Tadulako University Medical Undergraduate Program by using questionnaires to measure internal factors, external factors, and SDLR. The students’ cumulative grade point (GPA) was used to indicate academic achievement. The data were analyzed quantitatively using Structural Equation Modeling (SEM) analysis tools with alternative variance or component based SEM method called Partial Least Square (PLS). The results show that the characteristics of the students and the internal factors significantly affect the SDLR and the students’ academic achievement, while the external factors have no effect on the SDLR and the students’ academic achievement. The factors that have a higher effect on SDLR and student achievement are internal factors. The results also show that SDLR does not affect the students’ academic achievement.
Strategies for improving the implementation of e-learning method in undergraduate program
Authors: Muchlis Mohamad 
Published: September 2018

STRATEGI PENINGKATAN PENERAPAN METODE PEMBELAJARAN E-LEARNING PADA PROGRAM SARJANAAbstrakPenelitian ini bertujuan menganalisis persepsi dosen dan mahasiswa Departemen Manajemen Sumberdaya Perairan (MSP) terhadap penerapan metode pembelajaran e-learning dan merumuskan strategi peningkatan penerapan metode tersebut pada program sarjana Departemen MSP. Responden adalah mahasiswa aktif dan dosen Departemen MSP. Alat analisis data yang digunakan adalah service quality (SERVQUAL), Importance Performance Analysis (IPA), dan matriks importance-performance. Jenis data yang digunakan adalah data primer dan data sekunder. Data primer diperoleh dari hasil kuesioner yang telah diisi dan dilengkapi oleh responden. Data sekunder diperoleh melalui observasi dengan melakukan pengamatan langsung pada data-data internal. Analisis deskriptif digunakan untuk perumusan strategi. Penelitian ini menunjukan bahwa nilai rata-rata tingkat kepentingan atribut e-learning lebih tinggi dari nilai rata-rata tingkat kinerja atribut e-learning terkait penerapan metode pembelajaran e-learning. Departemen MSP perlu meningkatkan kinerja atribut e-learning dengan merumuskan beberapa strategi. Strategi yang direkomendasikan untuk meningkatkan kinerja tersebut adalah perbaikan sarana dan prasarana pendukung e-learning, sosialisasi e-learning, dan penyediaan tenaga teknisi pengelola e-learning. AbstractThis study was aimed at analyzing the perceptions of the lecturers and students of the Water Resources Management Department (WRMD) on the application of E-learning methods and formulating the strategies to improve the application of the method. The respondents were the active students and the lecturers of WRMD. The data analysis tools used were service quality (SERVQUAL), Importance Performance Analysis (IPA) and importance-performance matrix. The types of data used were primary and secondary data. The primary data were obtained from the questionnaire completed by the respondents. The secondary data were obtained through observation of internal data. Data were analyzed using the descriptive techniques. The results show that the average value of the importance of E-learning attribute is higher than the average value of E-learning attribute of performance level related to the application of the E-learning method. The WRMD needs to improve the performance of E-learning attributes by creating some strategies. The recommended strategies are improving E-learning support facilities and infrastructure, conducting E-learning socialization, and providing E-learning technical assistants.
A Smartphone App to Foster Power in the Everyday Management of Living With Schizophrenia: Qualitative Analysis of Young Adults’ Perspectives
Authors: Terp Malene , Jørgensen Rikke , Laursen Birgitte Schantz , Mainz Jan , Bjørnes Charlotte D 
Published: September 2018

BackgroundLiterature indicates that using smartphone technology is a feasible way of empowering young adults recently diagnosed with schizophrenia to manage everyday living with their illness. The perspective of young adults on this matter, however, is unexplored.ObjectiveThis study aimed at exploring how young adults recently diagnosed with schizophrenia used and perceived a smartphone app (MindFrame) as a tool to foster power in the everyday management of living with their illness.MethodsUsing participatory design thinking and methods, MindFrame was iteratively developed. MindFrame consists of a smartphone app that allows young adults to access resources to aid their self-management. The app is affiliated with a website to support collaboration with their health care providers (HCPs). From January to December 2016, community-dwelling young adults with a recent diagnosis of schizophrenia were invited to use MindFrame as part of their care. They customized the resources while assessing their health on a daily basis. Then, they were invited to evaluate the use and provide their perspective on the app. The evaluation was qualitative, and data were generated from in-depth interviews. Data were analyzed using a hermeneutical approach.ResultsA total of 98 individuals were eligible for the study (mean age 24.8, range 18-36). Of these, 27 used MindFrame and 13 participated in the evaluation. The analysis showed that to the young adults, MindFrame served to foster power in their everyday management of living with schizophrenia. When MindFrame was used with the HCPs consistently for more than a month, it could provide them with the power to keep up their medication, to keep a step ahead of their illness, and to get appropriate help based on their needs. This empowered them to stay on track with their illness, thus in control of it. It was also reported that MindFrame could fuel the fear of restraint and illness exacerbation, thereby disempowering some from feeling certain and secure.ConclusionsThe findings demonstrate that young adults diagnosed with schizophrenia are amenable to use a smartphone app to monitor their health, manage their medication, and stay alert of the early signs of illness exacerbation. This may empower them to stay on track with their illness, thus in control of it. This indicates the potential of smartphone-based care being capable of aiding this specific population to more confidently manage their new life situation. The potentially disempowering aspect of MindFrame accentuates a need for further research to understand the best uptake and the limitations of smartphone-based schizophrenia care of young adults.
Evocaciones desde el ojo del huracán
Authors: Revueltas Acevedo Eugenia 
Published: September 2018

<p>El presente ensayo es una narración parcial del movimiento estudiantil de 1968, desde el 23 de julio hasta el 2 de octubre, considerada como la primera etapa de la lucha. En el texto se entretejen la descripción de los hechos y documentos del periodo, así como memorias de perspectiva subjetiva del narrador, por considerar el hecho peculiar de que un detalle tan pequeño como un conflicto entre los estudiantes de una escuela preparatoria y una vocacional haya evolucionado tan rápidamente a un movimiento que conmocionó a la sociedad mexicana, por la valentía y la convicción de justicia y transformación necesarias que impulsaron a los muchachos, y la brutal violencia con la que el gobierno de México canceló el levantamiento.</p><p align="center"> </p>
Hubungan Asupan Makanan Indeks Glikemik Tinggi dan Aktivitas Fisik dengan Kadar Glukosa Darah pada Pasien Diabetes Mellitus Tipe Ii Rawat Jalan di RSUD Karanganyar
Authors: Mayawati Hernie , Isnaeni Farida Nur 
Published: September 2018

Asupan makanan dengan indeks glikemik tinggi merupakan salah satu faktor yang dapat menyebabkan tingginya kadar glukosa darah. Selain itu aktivitas fisik juga dapat mengubah glukosa menjadi energi, sehingga ringan atau beratnya aktivitas fisik dapat berpengaruh pada kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui hubungan asupan makanan indeks glikemik tinggi dan aktivitas fisik dengan kadar glukosa darah pada pasien diabetes mellitus tipe II rawat jalan di RSUD Karanganyar. Penelitian ini menggunakan metode observasional dengan pendekatan cross-sectional. Subjek penelitian yang digunakan adalah 52 pasien DM Tipe II yang berusia 40-65 tahun. Pengambilan sampel menggunakan accidental sampling. Data asupan makanan indeks glikemik tinggi diperoleh melalui teknik Semi Quantitatif Food Frequency Quesionnare (SQFFQ). Data aktivitas fisik menggunakan Form Recall 24 jam untuk mengetahui nilai PAL. Data kadar glukosa darah diperoleh dari catatan rekam medis RSUD Karanganyar. Uji statistik yang digunakan adalah Pearson Product Moment. Hasil penelitian menunjukkan bahwa sebagian besar responden mamiliki asupan makanan indeks glikemik tinggi yang rendah (65,4%), aktivitas fisik yang ringan (78,8%), dan kadar glukosa darah yang tinggi (69,2%). Responden dengan asupan indeks glikemik tinggi yang rendah cenderung memiliki kadar glukosa darah tinggi 64,7% (p= 0,276). Responden dengan aktivitas fisik ringan cenderung memiliki kadar glukosa darah tinggi 78% (p= 0,127). Tidak ada hubungan antara asupan makanan indeks glikemik tinggi dan aktivitas fisik dengan kadar glukosa darah pada pasien diabetes mellitus tipe II rawat jalan di RSUD Karanganyar.
Hereditary ataxia in four related Norwegian Buhunds
Authors: Mari Lorenzo , Matiasek Kaspar , Jenkins Christopher A. , De Stefani Alberta , Ricketts Sally L. , Forman Oliver , De Risio Luisa 
Published: September 2018

Abstract
CASE DESCRIPTION Two 12-week-old Norwegian Buhunds from a litter of 5 were evaluated because of slowly progressive cerebellar ataxia and fine head tremors. Two other females from the same pedigree had been previously evaluated for similar signs.
CLINICAL FINDINGS Findings of general physical examination, CBC, and serum biochemical analysis were unremarkable for all affected puppies. Brain MRI and CSF analysis, including PCR assays for detection of Toxoplasma gondii, Neospora caninum, and canine distemper virus, were performed for 3 dogs, yielding unremarkable results. Urinary organic acid screening, enzyme analysis of fibroblasts cultured from skin biopsy specimens, and brainstem auditory-evoked response testing were performed for 2 puppies, and results were also unremarkable.
TREATMENT AND OUTCOME The affected puppies were euthanized at the breeder's request, and their brains and spinal cords were submitted for histologic examination. Histopathologic findings included a markedly reduced expression of calbindin D28K and inositol triphosphate receptor 1 by Purkinje cells, with only mild signs of neuronal degeneration. Results of pedigree analysis suggested an autosomal recessive mode of inheritance. Candidate-gene analysis via mRNA sequencing for 2 of the affected puppies revealed no genetic variants that could be causally associated with the observed abnormalities.
CLINICAL RELEVANCE Findings for the dogs of this report suggested the existence of a hereditary form of ataxia in Norwegian Buhunds with histologic characteristics suggestive of Purkinje cell dysfunction. The presence of hereditary ataxia in this breed must be considered both in clinical settings and for breeding strategies.
Penerapan Game Design Document dalam Perancangan Game Edukasi yang Interaktif untuk Menarik Minat Siswa dalam Belajar Bahasa Inggris
Authors: Rahayu Sri Lestari , Fujiati Fujiati 
Published: September 2018

Pentingnya belajar bahasa inggris pada usia dini dikarenakan bahasa inggris merupakan bahasa internasional. Metode belajar pada anak usia dini adalah belajar sambil bermain, anak-anak juga akan lebih mudah untuk menerima informasi dalam bentuk multimedia. Media pembelajaran yang interaktif akan membantu anak dalam menguasai pelajaran bahasa inggris sejak dini. Pada penelitian ini penulis membuat Game edukasi sebagai media pembelajaran yang interaktif. Dalam pembuatan game edukasi yang interaktif dibutuhkan perancangan Game Desain Document. Pada saat anak belajar dengan metode konvensional maka anak akan susah memahami dan cepat bosan karena anak belajar dari buku dan mendengarkan guru menjelaskan tetapi dengan adanya game edukasi sebagai media pembelajaran yang interaktif maka diharapkan akan memudahkan anak dalam mempelajari, memahami dan menguasai bahasa asing khususnya bahasa inggris. Aplikasi game yang dibangun menggunakan metode Game Design Document (GDD) dan metode perancangannya menggunakan metode waterfall. Adapun hasil dari penelitian ini berupa aplikasi media pembelajaran dan mendapatkan nilai presentase 80% dari kuesioner yang diisi oleh pengguna. AbstractThe importance of learning English at an early age because English is an international language. The method of learning in early childhood is learning while playing, children will also be easier to receive information in multimedia form. Interactive learning media will help children to master English language lessons early. In this study the author makes educational games as interactive learning media. In making interactive educational games, it is necessary to design a Document Design Game. When the child learns by conventional methods, the child will be difficult to understand and get bored quickly because the child learns from the book and listens to the teacher explaining but with the educational game as an interactive learning media it is expected to facilitate the child in learning, understanding and mastering foreign languages, especially English . Game applications are built using the Game Design Document (GDD) method and the design method uses the waterfall method. The results of this study are in the form of learning media applications and get a percentage value of 80% from the questionnaire filled in by the user.