bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of genomic differentiation between two Lake Victoria cichlid species, Haplochromis pyrrhocephalus and H. sp. ‘macula’
Authors: Takuno Shohei , Miyagi Ryutaro , Onami Jun-ichi , Takahashi-Kariyazono Shiho , Sato Akie , Tichy Herbert , Nikaido Masato , Aibara Mitsuto , Mizoiri Shinji , Mrosso Hillary D. J. , Mzighani Semvua I. , Okada Norihiro , Terai Yohey 
Published: March 2019

AbstractBackgroundThe molecular basis of the incipient stage of speciation is still poorly understood. Cichlid fish species in Lake Victoria are a prime example of recent speciation events and a suitable system to study the adaptation and reproductive isolation of species.ResultsHere, we report the pattern of genomic differentiation between two Lake Victoria cichlid species collected in sympatry,Haplochromis pyrrhocephalusandH.sp. ‘macula,’ based on the pooled genome sequences of 20 individuals of each species. Despite their ecological differences, population genomics analyses demonstrate that the two species are very close to a single panmictic population due to extensive gene flow. However, we identified 21 highly differentiated short genomic regions with fixed nucleotide differences. At least 15 of these regions contained genes with predicted roles in adaptation and reproductive isolation, such as visual adaptation, circadian clock, developmental processes, adaptation to hypoxia, and sexual selection. The nonsynonymous fixed differences in one of these genes,LWS, were reported as substitutions causing shift in absorption spectra of LWS pigments. Fixed differences were found in the promoter regions of four other differentially expressed genes, indicating that these substitutions may alter gene expression levels.ConclusionsThese diverged short genomic regions may have contributed to the differentiation of two ecologically different species. Moreover, the origins of adaptive variants within the differentiated regions predate the geological formation of Lake Victoria; thus Lake Victoria cichlid species diversified via selection on standing genetic variation.
Claims-Based Approach to Predict Cause-Specific Survival in Men With Prostate Cancer
Authors: Riviere Paul , Tokeshi Christopher , Hou Jiayi , Nalawade Vinit , Sarkar Reith , Paravati Anthony J. , Schiaffino Melody , Rose Brent , Xu Ronghui , Murphy James D. 
Published: March 2019

PURPOSE Treatment decisions about localized prostate cancer depend on accurate estimation of the patient’s life expectancy. Current cancer and noncancer survival models use a limited number of predefined variables, which could restrict their predictive capability. We explored a technique to create more comprehensive survival prediction models using insurance claims data from a large administrative data set. These data contain substantial information about medical diagnoses and procedures, and thus may provide a broader reflection of each patient’s health. METHODS We identified 57,011 Medicare beneficiaries with localized prostate cancer diagnosed between 2004 and 2009. We constructed separate cancer survival and noncancer survival prediction models using a training data set and assessed performance on a test data set. Potential model inputs included clinical and demographic covariates, and 8,971 distinct insurance claim codes describing comorbid diseases, procedures, surgeries, and diagnostic tests. We used a least absolute shrinkage and selection operator technique to identify predictive variables in the final survival models. Each model’s predictive capacity was compared with existing survival models with a metric of explained randomness (ρ2) ranging from 0 to 1, with 1 indicating an ideal prediction. RESULTS Our noncancer survival model included 143 covariates and had improved survival prediction (ρ2 = 0.60) compared with the Charlson comorbidity index (ρ2 = 0.26) and Elixhauser comorbidity index (ρ2 = 0.26). Our cancer-specific survival model included nine covariates, and had similar survival predictions (ρ2 = 0.71) to the Memorial Sloan Kettering prediction model (ρ2 = 0.68). CONCLUSION Survival prediction models using high-dimensional variable selection techniques applied to claims data show promise, particularly with noncancer survival prediction. After further validation, these analyses could inform clinical decisions for men with prostate cancer.
Attitudes of Terminally Ill Cancer Patients About Euthanasia and Assisted Suicide: Predominance of Psychosocial Determinants and Beliefs Over Symptom Distress and Subsequent Survival
Authors: Suarez-Almazor Maria E. , Newman Catherine , Hanson John , Bruera Eduardo 
Published: March 2019

PURPOSE: Although euthanasia and physician-assisted suicide (PAS) are controversial issues, the views of those most affected, terminal patients, are seldom explored. Our objective was to assess whether the attitudes about euthanasia/PAS of terminally ill cancer patients were determined by their symptomatic distress. PATIENTS AND METHODS: We conducted a survey of 100 patients with terminal cancer. Statements related to the legalization of euthanasia/PAS were scored using Likert scales. We also asked patients how often they had considered ending their lives. Their responses were analyzed in relation to disease characteristics, including an assessment of symptomatic severity, sociodemographic features, general beliefs about the suffering of cancer patients, and survival. RESULTS: Most patients (69%) supported euthanasia or PAS for one or more situations. The association between these attitudes and symptoms was weak, consistent in univariate analysis only for shortness of breath. No significant associations were observed with pain, nausea, well-being, loss of appetite, depression, or subsequent survival. Agreement with euthanasia was significantly related to male sex, lack of religious beliefs, and general beliefs about the suffering of cancer patients and their families. In multivariate analysis, the only characteristics that remained statistically associated with support were the strength of religious beliefs and the perception that patients with cancer are a heavy burden on their families. Frequency of suicidal ideation was associated with poor well-being, depression, anxiety, and shortness of breath, but not with other somatic symptoms such as pain, nausea, and loss of appetite. CONCLUSION: Symptom intensity had limited impact on the attitudes about euthanasia of terminally ill cancer patients. Our findings suggest that patient views are primarily determined by psychosocial traits and beliefs, as opposed to disease severity or symptomatic distress.
Beyond the “Proper Notice”: Frederick Douglass,Uncle Tom’s Cabin, and the Politics of Critical Reprinting
Authors: Gordon Adam 
Published: March 2019

AbstractThis essay takes the critical reception of Uncle Tom’s Cabin in Frederick Douglass’ Paper as an occasion to rethink modern constructions of critical authority while arguing for a print culture approach to literary criticism. Although scholars of antebellum culture typically focus on critical responses that are most readable by twenty-first-century standards (lengthy, signed reviews by readily identifiable critics in prestigious journals), paradoxically the less authoritative liminal critical forms (unsigned, unoriginal criticism circulated as reprinted reviews) displayed the centrality of criticism to nineteenth-century social and political life in the United States. Drawing on an expanded archive of eclectic critical forms, this essay denaturalizes and expands our sense of antebellum critical culture, examining the ways Frederick Douglass exploited the material diversity of contemporary print culture as part of his antislavery strategy, reprinting responses to Harriet Beecher Stowe’s novel in an array of nontraditional critical forms to achieve pragmatic political goals. In so doing, Douglass transformed literary criticism from evaluation and entertainment into a powerful weapon in the war against slavery and the promotion of the interests of African Americans, applications that reaffirm the essay’s claim for the importance of a material approach to critical culture.
Spontaneous lumbar artery rupture and massive retroperitoneal hematoma, successfully treated with arteriographic embolization
Authors: Kim Jin Yong , Lee Song Am , Hwang Jae Joon , Park Jae Bum , Park Sang Woo , Kim Yo Han , Moon Hyeong Ju , Lee WooSurng 
Published: March 2019

Background and Objective: Massive retroperitoneal hematoma caused by lumbar artery rupture is generally associated with trauma or retroperitoneal malignancy. However, despite recent advances in technologies and tools, spontaneous lumbar artery rupture is a very rare disease entity but remains a challenging problem because it is frequently associated with significantly high mortality and morbidity and is very difficult to make a correct diagnosis.
Methods: We evaluated the databases of the PubMed, Embase, Cochrane Central Register of Controlled Trial, Google Scholar, the KoreaMed and the Research Information Sharing Service databases, and a detailed systematic review was performed by searching in PubMed. The initial search was performed on 3 February 2018 and a second search conducted in 29 January 2019.
Results: A total of 10 case reports on massive hemoperitoneum caused by spontaneous lumbar artery rupture were identified. Of the 10 case reports involving 14 patients, eight were male and six were female under 62.71 ± 13.93. Of the 14 patients, 9 (64.3%) surviving with transcatheter arterial embolization, three (21.4%) died of multi-organ failure or hypovolemia, and two (14.3%) had no definite records on survival or death.
Conclusions: A massive retroperitoneal hematoma caused by lumbar artery rupture should be considered in patients with late-onset shock accompanied by blunt abdominal/pelvic trauma. Furthermore, early detection and urgent embolization would prevent further complications and eliminate the need for surgical interventions.
How to cite this:Kim JY, Lee SA, Hwang JJ, Park JB, Park SW, Kim YH, et al. Spontaneous lumbar artery rupture and massive retroperitoneal hematoma, successfully treated with arteriographic embolization. Pak J Med Sci. 2019;35(2):569-574. doi: https://doi.org/10.12669/pjms.35.2.639
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
MIST: A multi-resolution parcellation of functional brain networks
Authors: Urchs Sebastian , Armoza Jonathan , Moreau Clara , Benhajali Yassine , St-Aubin Jolène , Orban Pierre , Bellec Pierre 
Published: March 2019

The functional architecture of the brain is organized across multiple levels of spatial resolutions, from distributed networks to the localized areas they are made of. A brain parcellation that defines functional nodes at multiple resolutions is required to investigate the functional connectome across these scales. Here we present the Multiresolution Intrinsic Segmentation Template (MIST), a multi-resolution group level parcellation of the cortical, subcortical and cerebellar gray matter. The individual MIST parcellations match other published group parcellations in internal homogeneity and reproducibility and perform very well in real-world application benchmarks. In addition, the MIST parcellations are fully annotated and provide a hierarchical decomposition of functional brain networks across nine resolutions (7 to 444 functional parcels). We hope that the MIST parcellation will accelerate research in brain connectivity across resolutions. Because visualizing multiresolution parcellations is challenging, we provide an interactive web interface to explore the MIST. The MIST is also available through the popular nilearn toolbox.
A seven-year study on the effect of the pre-erythrocytic malaria vaccine candidate RTS,S/AS01E on blood stage immunity in young Kenyan children
Authors: Ndungu Francis M. , Mwacharo Jedida , Wambua Juliana , Njuguna Patricia , Marsh Kevin , Drakeley Chris , Bejon Philip 
Published: March 2019

Background: RTS,S/AS01 E, the most advanced malaria vaccine confers partial immunity. The vaccine-induced pre-erythrocytic immunity reduces exposure to blood-stage parasites, delaying acquisition of antibodies to blood-stage antigens. However, the duration of this effect is unknown. Methods: We measured, by enzyme-linked immunosorbent assay, IgG-antibodies to 4 Plasmodium falciparum blood-stage antigens (AMA1, MSP142, EBA175, and MSP3) on 314 children randomized to receive RTS,S/AS01 E or Rabies vaccine at 5 – 17 months of age in a phase 2b trial in Kenya, and thereafter participated in a 7-year study of the duration of vaccine immunity. Results: Antibody levels to MSP142, AMA1 and EBA175 were slightly lower among the RTS,S/AS01 E recipients, relative to the Rabies-control vaccinees, during the first 48 months of surveillance. Irrespective of vaccine arm, antibody levels to merozoite antigens were positively associated with the risk for malaria. However, this was only apparent at high levels for EBA175 and AMA1 and was not evident after adjusting for heterogeneity in malaria-exposure. Among children with asymptomatic parasitaemia, antibody levels were associated with reduced clinical malaria. Conclusions: The reduction in levels of antibodies to blood-stage antigens induced by vaccination with RTS,S/AS01 E can last for several years. In absence of asymptomatic infection, anti-merozoite antibody levels were unreliable correlates of clinical immunity.
Grain Yield, Crop and Basal Evapotranspiration, Production Functions and Water Productivity Response of Drought-tolerant and Non-drought-tolerant Maize Hybrids under Different Irrigation Levels and Population Densities: Part I. In Western Nebraska’s Semi-
Authors: Mohammed Ali T. , Irmak Suat , Kranz William L. , van Donk Simon , Yonts C. Dean 
Published: March 2019

Abstract.Grain yield, crop evapotranspiration (ETc), basal evapotranspiration (ETb), ETc-yield production functions (ETYPF), and crop water use efficiency (CWUE) response of three drought-tolerant (DT) and one non-drought-tolerant (NDT) maize ( L.) hybrids to two plant population densities (PPDs) [84,000 plants ha-1 (high PPD) and 59,300 plants ha-1 (low PPD)] and three irrigation levels were researched at two semi-arid locations: North Platte (WCREC) and Scottsbluff (MAL), Nebraska, in 2010, 2011, and 2012. The irrigation levels were fully irrigated (FIT), early cutoff (ECOT), and rainfed (RFT). Precipitation in 2010 was above average, 2011 was a normal year, and 2012 was one of the driest and hottest years in Nebraska’s recorded history. Generally, DT hybrids performed better than the NDT hybrid. The performances of the DT hybrids were stronger in the driest year and driest location (MAL), especially with low PPD. ETc exhibited inter-annual variation for the same hybrid in the same location and between the two locations and also with the PPD and irrigation treatments. There were significant differences (P&lt;0.05) between the ETc values for the same hybrids across three irrigation treatments. The grain yield response to hybrids and treatments also exhibited substantial variation for the same hybrid between the PPDs and had inter-annual variation between the years and locations. The greatest grain yields of 14.6 and 18.0 Mg ha-1 were observed with 548 and 837 mm of ETc, which were recorded for the DT hybrid H3 (high PPD) at WCREC and MAL, respectively. There were significant differences (P&lt;0.05) in performance among the DT hybrids in performance variables (ETc, ETb, ETYPF, CWUE). In most cases, the DT hybrids produced greater grain yield than the NDT hybrid with lower ETc. In terms of ETYPF response for individual hybrids, the slope of the production functions exhibited an inter-annual variation between the hybrids and for the same hybrids between the years and location for both high and low PPDs. All hybrids exhibited a linear yield response to increasing ETc in all years at both locations with positive slopes in all cases with DT hybrids having the greatest slopes. The ETb values also exhibited a substantial variation between the hybrids, years, locations, and PPDs. Generally, DT hybrids had sizably lower ETb values than the NDT hybrid in both PPD levels. It was concluded that DT hybrids increase the grain yield production per unit of ETc in semi-arid regions not only during very dry and hot year, but also during the growing season with favorable rainfall and climate conditions. Keywords: Basal evapotranspiration, Drought-tolerance, Maize, Yield production functions.
La evaluación de la competencia “trabajo en equipo” de los estudiantes universitarios
Authors: París Mañas Georgina , Mas Torelló Oscar , Torrelles Nadal Cristina 
Published: March 2019

El presente artículo tiene como objetivo evaluar la competencia de trabajo en equipo de los estudiantes universitarios, para detectar sus potencialidades y debilidades. Para ello se ha contactado con 180 estudiantes procedentes de diferentes grados universitarios configurando así una muestra de carácter no probabilístico. El proceso metodológico de ésta investigación consiste en una autoevaluación y una coevaluación entre los miembros pertenecientes a un mismo equipo de trabajo y el instrumento de recogida de los datos es la Rúbrica RUTE-Rúbrica de Trabajo en Equipo. Esta evaluación multiactores tiene una doble aplicación: por un lado, se evalúa al sujeto a partir de la información proporcionada por los compañeros del equipo, este proceso es conocido como coevaluación; y por otro lado, es el propio sujeto quien se autoevalúa su competencia de trabajo en equipo, conocido éste como la autoevaluación. Los resultados muestran que los estudiantes universitarios destacan por su implicación en los logros del equipo, por la sensación de pertenencia dentro del equipo y su capacidad para anticiparse a los problemas y encontrar una solución de consenso. No obstante, otras dimensiones de la competencia como la coordinación entre todos los miembros, la flexibilidad, la adaptabilidad y la participación son elementes para mejorar.
Histopathological Features of Drug-Induced Liver Injury Secondary to Osimertinib
Authors: González Iván , Chatterjee Deyali 
Published: March 2019

Abstract
In the past few years, a better understanding of the genomic alterations in lung cancer has facilitated a targeted therapy. Lung adenocarcinomas with epidermal growth factor receptor mutations have a good response to tyrosine kinase inhibitors (TKIs). Osimertinib is a third-generation TKI approved by the Food and Drug Administration (FDA). Drug-induced liver injury is a well-known adverse effect of TKIs as a group and reported to show an autoimmune hepatitis-like picture. However, little is known about the histopathologic changes with osimertinib. We present a case of drug-induced liver injury secondary to osimertinib and discuss the histopathologic findings.
DETERMINAN IMPOR SERAT KAPAS DI INDONESIA TAHUN 1975-2014 (PENDEKATAN ERROR CORRECTION MECHANISM)
Authors: Hanifah Nida'ul , Kartiasih Fitri 
Published: March 2019

The activity of textile sector and textile product (TPT) in Indonesia keeps growing from year to year.TPTIndustry has become the main contributor of foreign exchange from non-oil and gas sector. Unfortunately, the domestic supply of cotton fiber, main material of textile product, can’t fulfill textile industry’s demand. It forces the nation to import the raw materials. Based on the problem about the import that still exist until the present, it is necessary to do a research to analyze the development of cotton fiber import in Indonesia and to identify the factors affecting the development of Indonesian cotton fiber imports during 1975-2014. This research uses descriptive analysis and inference analysis. The descriptive analysis method used in this research is graphical analysis, while the inference analysis is Error Correction Mechanism (ECM) method. Based on the estimation made with ECM, it was found that 5 variables significantly affect the cotton import volume in the long term, including: real per capita Gross Domectic Product (GDP), international cotton fiber prices, domestic cotton fiber production, the demand of cotton fiber by domestic yarn spinning industry and textile product exports volume. While in short term, only 4 variables significantly affect thecotton fiber import volume: domestic cotton fiber production,the demand of cotton fiber by domestic yarn spinning industry, real per capita GDP and textile product exports volume. Keywords: import, cotton fiber, Textile Industry and Textile Product (TPT),Error Correction Mechanism (ECM).
ATURAN REKOMENDASI BARANG MENGGUNAKAN MULTI LEVEL ASSOCIATION RULES MINING (ML-ARM)
Authors: Tyas Zahra Arwananing 
Published: March 2019

Sistem rekomendasi dapat menghasilkan rekomendasi dengan berbagai cara dan menggunakan berbagai macam metode, salah satunya adalah memanfaatkan tumpukan kasus lama atau tumpukan data transaksi lama yang dapat menghasilkan informasi atau aturan dengan metode Association Rules Mining(ARM). Aturan terbentuk dengan metode multi level ARM dan menghasilkan 5 aturan yang akan dicocokkan dengan masukan pengguna. Saat aturan ditemukan cocok maka consequent dari aturan tersebut akan dijadikan hasil rekomendasi. Hasil pengujian dari aturan yang terbentuk memiliki nilai akurasi 94,12% dan nilai precision, recall dan F-measure untuk sistem rekomendasi ini pada proses rekomendasi dengan aturan yaitu berturut 0,475; 0,513 dan 0,25.
"A Body Without a Head". The Elite of the Muslim Minority in the Bulgarian Lands at the Turn of the 20th Century
Authors: Popek Krzysztof 
Published: March 2019

Ciało bez głowy”. Elita mniejszości muzułmańskiej na ziemiach bułgarskich na przełomie XIX i XX wieku Wojna rosyjsko-turecka lat 1877–1878 zakończyła panowanie osmańskie na ziemiach bułgarskich, co równocześnie doprowadziło do wielkiej emigracji ludności muzułmańskiej. Osmańskie elity jako pierwsze opuściły odrodzoną Bułgarię. Urzędnicy, hodżowie, imamowie, oficerzy, posiadacze ziemscy, mieszczanie oraz inteligenci wyjeżdżali do Imperium Osmańskiego w obawie przed rozliczeniami za powiązaniami z dawnymi władzami. Następnie, po zjednoczeniu Księstwa Bułgarii i Rumelii Wschodniej w 1885 roku, doszło do nowej fali migracyjnej muzułmańskich urzędników, działaczy lokalnych oraz oficerów milicji z ziem Bułgarii południowej. W okresie 1879–1949, w 80% muzułmanie w Bułgarii byli drobnymi chłopami, 19% żyli w miastach i pracowali jako rzemieślnicy, jedynie 1% miał szanse zrobić karierę. Artykuł skupia się na trzech grupach elity mniejszości muzułmańskiej w Bułgarii, co koresponduje z tradycyjnym podziałem elit: polityczna (mufti), ekonomiczna (posiadacze ziemscy, kupcy, przedsiębiorcy) oraz intelektualna (nauczyciele – hodżowie).
Numerical Modelling of Fish Passage with Turning Pools
Authors: Maniecki Łukasz 
Published: March 2019

Abstract
An assessment of operating conditions in a baffled fish passage with pool dimensions of 2.2 × 3.0 m, and 180° horizontally turning pools, was carried out using numerical computations and a site survey of water flow velocity distribution. Velocity was measured with a PMS electromagnetic flowmeter and a hydrometric current meter in representative cross-sections of the fish passage in the pool centres and in the baffle barrier cross-section area. Numerical computations were also performed for two alternative baffle locations in the fishway. One reflected the actual conditions, and the other was an alternative arrangement designed to improve hydraulic conditions for fish migration. The numerical model used the Large Eddy Simulation (LES) method, which makes it possible to detect large vortexes. The study pays close attention to the velocity field analysis as well as the distribution and sizes of vortexes in the turning pool of the culvert. The results of numerical computations and the site survey show high consistency, and the proposed baffle placement modification significantly improves flow conditions, especially in the entry section of the passage.