bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variability and Costs of Low-Value Preoperative Testing for Carpal Tunnel Release Surgery
Authors: Harris Alex H. S. , Meerwijk Esther L. , Kamal Robin N. , Sears Erika D. , Hawn Mary , Eisenberg Dan , Finlay Andrea K. , Hagedorn Hildi , Mudumbai Seshadri 
Published: June 2019

BACKGROUND:
The American Society of Anesthesiologists (ASA) Choosing Wisely Top-5 list of activities to avoid includes “Don’t obtain baseline laboratory studies in patients without significant systemic disease (ASA I or II) undergoing low-risk surgery - specifically complete blood count, basic or comprehensive metabolic panel, coagulation studies when blood loss (or fluid shifts) is/are expected to be minimal.” Accordingly, we define low-value preoperative tests (LVTs) as those performed before minor surgery in patients without significant systemic disease. The objective of the current study was to examine the extent, variability, drivers, and costs of LVTs before carpal tunnel release (CTR) surgeries in the US Veterans Health Administration (VHA).

METHODS:
Using fiscal year (FY) 2015–2017 data derived from the VHA Corporate Data Warehouse (CDW), we determined the overall national and facility-level rates and associated costs of receiving any of 8 common LVTs in the 30 days before CTR in ASA physical status (PS) I-II patients. We also examined the patient, procedure, and facility factors associated with receiving ≥1 LVT with mixed-effects logistic regression and the number of tests received with mixed-effects negative binomial regression.

RESULTS:
From FY15–17, 10,000 ASA class I-II patients received a CTR by 699 surgeons in 125 VHA facilities. Overall, 47.0% of patients had a CTR that was preceded by ≥1 LVT, with substantial variability between facilities (range = 0%–100%; interquartile range = 36.3%), representing $339,717 in costs. Older age and female sex were associated with higher odds of receiving ≥1 LVT. Local versus other modes of anesthesia were associated with lower odds of receiving ≥1 LVT. Several facilities experienced large (>25%) increases or decreases from FY15 to FY17 in the proportion of patients receiving ≥1 LVT.

CONCLUSIONS:
Counter to guidance from the ASA, we found that almost half of CTRs performed on ASA class I-II VHA patients were preceded by ≥1 LVT. Although the total cost of these tests is relatively modest, CTR is just one of many low-risk procedures (eg, trigger finger release, cataract surgery) that may involve similar preoperative testing practices. These results will inform site selection for qualitative investigation of the drivers of low-value testing and the development of interventions to improve preoperative testing practice, especially in locations where rates of LVT are high.
Prevalence of Egfr, Ki-67, Nf-Κb, Ma-1 marker in cleft affected tissue of soft palate
Authors: Tellermann Jonas , Reiser Sophie Charlotte , Pilmane Mara 
Published: June 2019

Introduction. Midline orofacial defects bear a high degree of morbidity for the affected individual, often associated with retardation in neonatal development and the need for surgical intervention. The etiology of the deformities, despite their high prevalence, remains, however, largely unknown. We report on the evaluation and quantification of proliferative and inflammatory markers in the cleft affected soft palate.
Material and methods. This study included soft palate samples of eight cleft lip and palate affected individuals and a control group of six soft tissue specimens obtained during correctional surgery of hyperdentia. All samples were processed via immunohistochemistry for marker EGFR, NF-κB, Ki-67, Ma-1. The results were evaluated semi-quantitatively and statistically analysed by IBM SPSS 25.0.
Results. Histopathological signs of inflammatory changes were continuous in cleft affected specimen. The quantitative distribution of the markers in the cleft affected group displayed a significant correlation between EGFR, Ki-67 and NF-κB (p< 0.05), along with a correlation among Ki-67 and NF-κB (p< 0.05). Immunoreactive structures in control group showed lower numbers in all evaluated specimen. A statistical significance between cleft affected and non-cleft tissue was observed in EGFR and Ma-1 (p< 0.05).
Conclusion. Results are suggestive of a tissue phenotype modification in cleft affected palate. Observation of distribution and statistical correlation hint towards the involvement of epithelial growth inducer EGFR and inflammatory/ proliferative marker in epithelial changes.
Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis
Authors: Li Wei , Lin Edward L. , Liangpunsakul Suthat , Lan Jie , Chalasani Sai , Rane Sushmita , Puri Puneet , Kamath Patrick S. , Sanyal Arun J. , Shah Vijay H. , Radaeva Svetlana , Crabb David W. , Chalasani Naga , Yu Qigui 
Published: June 2019

OBJECTIVES:
Alcoholic hepatitis (AH) develops in approximately 30% of chronic heavy drinkers. The immune system of patients with AH is hyperactivated, yet ineffective against infectious diseases. Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that are highly enriched in liver, mucosa, and peripheral blood and contribute to antimicrobial immunity. We aimed to determine whether MAIT cells were dysregulated in heavy drinkers with and without AH and the effects of alcohol abstinence on MAIT cell recovery.

METHODS:
MR1 tetramers loaded with a potent MAIT cell ligand 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil were used in multiparameter flow cytometry to analyze peripheral blood MAIT cells in 59 healthy controls (HC), 56 patients with AH, and 45 heavy drinkers without overt liver disease (HDC) at baseline and 6- and 12-month follow-ups. Multiplex immunoassays were used to quantify plasma levels of cytokines related to MAIT cell activation. Kinetic Turbidimetric Limulus Amebocyte Lysate Assay and ELISA were performed to measure circulating levels of 2 surrogate markers for bacterial translocation (lipopolysaccharide and CD14), respectively.

RESULTS:
At baseline, patients with AH had a significantly lower frequency of MAIT cells than HDC and HC. HDC also had less MAIT cells than HC (median 0.16% in AH, 0.56% in HDC, and 1.25% in HC). Further, the residual MAIT cells in patients with AH expressed higher levels of activation markers (CD69, CD38, and human leukocyte antigen [HLA]-DR), the effector molecule granzyme B, and the immune exhaustion molecule PD-1. Plasma levels of lipopolysaccharide and CD14 and several cytokines related to MAIT cell activation were elevated in patients with AH (interferon [IFN]-α, interleukin [IL]-7, IL-15, IL-17, IL-18, IL-23, IFN-γ, and tumor necrosis factor α). Decreased MAIT cell frequency and upregulated CD38, CD69, and HLA-DR correlated negatively and positively, respectively, with aspartate aminotransferase level. MAIT cell frequency negatively correlated with IL-18. HLA-DR and CD38 levels correlated with several cytokines. At follow-ups, abstinent patients with AH had increased MAIT cell frequency and decreased MAIT cell activation. However, MAIT cell frequency was not fully normalized in patients with AH (median 0.31%).

DISCUSSION:
We showed that HDC had a reduction of blood MAIT cells despite showing little evidence of immune activation, whereas patients with AH had a severe depletion of blood MAIT cells and the residual cells were highly activated. Alcohol abstinence partially reversed those abnormalities.
How Are Book Covers and Their Components Represented in the Digital Market?
Authors: Darling Sophie 
Published: June 2019

This article discusses the way in which the book cover and its elements are represented in and translated into the digital market. It opens up the space for discussion about which components of the print cover design translate successfully and are most applicable to the digital market. In particular, it considers how metadata is used alongside the cover image within the digital selling space. This is achieved through two in-depth interviews conducted with currently active cover designers who experienced the digitisation of the book industry first-hand. It is also achieved through a detailed case study of the unique company Blind Date with a Book, and their use of metadata clues instead of a book cover. The article concludes that the book “cover” in the digital market is a deconstructed version of its physical counterpart. It is formed of a cover image and various elements of metadata, released from the boundaries and limits of the physical print book. Instead, the digital cover exists in the online selling space – the webpage.
Pengaruh waktu pemangkasan pucuk dan sisa buah setelah penjarangan terhadap hasil produksi tanaman semangka (Citrullus vulgaris schard)
Authors: Yuriani Anita Dwi , Fuskhah Eny , Yafizham Yafizham 
Published: June 2019

ABSTRACT The objective of this research was to know growth and the production of watermelon plants through the treatment of pruning time on shoots and the amount of residual fruit after thinning. The research was carried out on Klaten Watermelon Clay, located in Genukan Village, Wedi Sub-district, Klaten District, and at the Laboratory Chemistry and Food Nutrition Faculty of Animal and Agricultural Sciences, Diponegoro University from February to May 2017. The research was arranged using completely randomized factorial design with the first factor being shoot pruning time (P1 = no trimming, P2 = 3rd week, P3 = 6th week, P4 = 3rd and 6th week) and the second factor was the rest of the fruit after thinning (Q1 = without thinning, Q2 = thinning leaves 1 piece, Q3 = thinning leaves 2 pieces). The results showed the treatment of pruning of shoots and the remaining fruit after spacing did not affect the growth plant height and number of leaves watermelon until 8th week. However pruning of shoots 3rd week and 6th week can affect fruit diameter, fresh fruit weight, and fruit sugar levels. Treatment of the remaining fruit after the spacing is pruned 2 pieces affect the diameter of fruit and fresh weight of fruit while the rest of the fruit after spacing is purned 1 pieces fruit affect the fruit sugar levels. Keywords: watermelon, pruning, thinning, production ABSTRAK Penelitian bertujuan untuk mengetahui pertumbuhan dan hasil produksi tanaman buah semangka melalui perlakuan waktupemangkasan pada pucuk dan jumlah sisa buah setelah penjarangan. Penelitian ini dilaksanakan pada di lahan Sahabat Semangka Klaten, yang terletak di Desa Genukan, Kecamatan Wedi, Kabupaten Klaten, dan di Laboratorium Kimia dan Gizi Pangan Fakultas Peternakan dan Pertanian Universitas Diponegorodari bulan Juli - September2017. Penelitian disusun menggunakan rancangan acak lengkap factorial dengan faktor pertama adalah waktu pemangkasan pucuk (P1 = tanpa pemangkasan, P2 = minggu ke 3, P3 = minggu ke 6, P4 = minggu ke 3 dan 6) danfaktor kedua adalah sisa buah setelah penjarangan (Q1 = tanpa penjarangan, Q2 = penjarangan disisakan 1 buah, Q3 = penjarangan disisakan 2 buah). Hasil penelitian menunjukan perlakuan pemangkasan pucuk dan sisa buah setelah penjarangan tidak mempengaruhi pertumbuhan tinggi tanaman dan jumlah daun semangka sampai minggu ke 8. Namun pemangkasan pemangkasan pucuk minggu ke 3 dan 6 mempengaruhi diameter buah, bobot segar buah, dan kadar gula buah. Perlakuan sisa buah setelah penjarangan yang dijarangkan 2 buah mempengaruhi diameter buah dan bobot segar buah sedangkan sisa buah setelah penjarangan yang dijarangkan 1 buah mempengaruhi kadar gula buah.Kata Kunci: semangka, pemangkasan, penjarangan, produksi
Hereditary hyperferritinaemia-cataract syndrome (HHCS) – an underestimated condition: ferritin light chain variant spectrum in German families
Authors: Volkmann Martin , Richter Rudolf , Herrmann Thomas , Hentze Sabine , Hör Michaela , Hasche Hendrik , Selle Barbara , Stremmel Wolfgang , Gehrke Sven G. 
Published: June 2019

Abstract

Background
In hereditary hyperferritinaemia-cataract syndrome (HHCS), single nucleic acid alterations in the ferritin light chain (L-ferritin) iron response element (IRE) constitutively derepress ferritin synthesis, resulting in hyperferritinaemia, L-ferritin deposits in the lens of the eye and early bilateral cataract onset.

Methods
In this study, six German families with putative HHCS were analysed. Clinical diagnosis of HHCS was based on medical history, evaluation of ferritin serum levels, transferrin saturation and clinical ophthalmological examination. Diagnosis was confirmed by polymerase chain reaction (PCR)-based DNA sequencing of the L-ferritin IRE.

Results
Genetic analysis of the L-ferritin IRE revealed relevant single nucleic acid alterations in each of the affected families. Variants c.-168G > A, c.-168G > U and c.-167C > U were located in the C-bulge region; and variants c.-161C > U and c.-157G > A were located in the hexanucleotide loop of the L-ferritin IRE.

Conclusions
Family history of hyperferritinaemia and juvenile cataracts are strong indicators of HHCS. Genetic analysis of the L-ferritin IRE is a straightforward procedure to confirm the diagnosis. Accurate diagnosis of hyperferritinaemia can avoid unnecessary treatment by venesection, and focus attention on early cataract detection in offspring at risk.
Solutes in sap obtained from supercritical CO2 dewatering of radiata pine sapwood, and a new role of sap cyclitols in brown stain formation during kiln drying of green wood
Authors: Franich Robert A. , Kroese Hank , Gallagher Suzanne , Steward Diane , Isak Ilena 
Published: June 2019

Abstract
Xylem sap obtained from radiata pine sapwood using a supercritical CO2 (scCO2) dewatering process contained a complex mixture of solutes comprising carbohydrates, amino acids, alkanoic and diterpene acids, neutral diterpenoids, β-sitosterol and cyclitols. Sap also contained free phosphoric acid which is known to catalyse the condensation reactions between glutamic and aspartic amino acids and glucose, galactose and fructose to form Maillard products. When heated these Maillard products lead to the formation of melanoidins, which are partly responsible for the formation of kiln brown stain (KBS) when green radiata pine sapwood is kiln dried. The cyclitols, which are major components in sap, have been shown to undergo phosphoric acid-catalysed dehydration reactions under kiln drying conditions to give methoxyl derivatives of hydroquinone, catechol, resorcinol and O-methylphloroglucinol. These reactive phenols are known to exothermally condense with formaldehyde and could also react with other short carbon chain aldehydes generated during kiln drying. The products of these chemical reactions are extended π-orbital aromatic polymers which are darkly-coloured and would be expected to contribute to KBS. This paper describes the chemistry of sap from radiata pine sapwood using scCO2 dewatering and proposes new theory on KBS formation invoking thermal dehydration and retro Diels-Alder chemical reactions of the sap cyclitols.
Racism in recent Greek migrant jokes
Authors: Archakis Argiris , Tsakona Villy 
Published: June 2019

Abstract
One of Davies’ significant contributions to the sociology of humor involves the exploration of the relation between jokes and the social order. He particularly argues that jokes seem to work like a “thermometer” conveying truths for the sociopolitical system. In our study, we aim to analyze jokes related to the migration crisis and circulated online since 2014 following Davies’ methodological guidelines. During the past few years, the number of migrants arriving at Greek shores has significantly increased. The prospect of Greece becoming a permanent base for these people has evoked diverse reactions. Migrant jokes seem to be part of Greek majority’s response to the migration ‘threat’ against national sovereignty and linguocultural homogeneity. They (re)produce and perpetuate xenophobia and racism by portraying migrants as ‘dangerous invaders’ in the Greek territory and as ‘culturally inferior’ people. Hence, such jokes align with dominant values and standpoints circulating in the Greek public sphere via underscoring the inequality between the Greek majority and migrants and via naturalizing the latter’s assimilation to majority norms and values.
Rapid and Non-Destructive Detection of Water-Injected Pork Using Low-Field Nuclear Magnetic Resonance (LF-NMR) and Magnetic Resonance Imaging (MRI)
Authors: Gai Shengmei , Zhang Zhonghui , Zou Yufeng , Liu Dengyong 
Published: June 2019

Abstract
The challenges of food adulteration such as illegal production of water-injected meat remain serious in many areas of the world. This study investigated the feasibility of using LF-NMR and MRI to identify water-injected pork. Longissimus dorsi muscles were injected with 0 %, 5 %, 10 %, 15 %, 20 % and 25 % content of deionized water, respectively. The CPMG decay curves of water-injected pork decayed slower than that of the normal. The peak area proportion of immobilized water of water-injected pork decreased while relaxation time and peak area proportion of free water increased significantly (p < 0.05). The first two principal components (PCs) of PCA accounted for 54.54 % and 32.06 % of the observed variance, respectively. Based on the two PCs, the water-injected pork could be differentiated from the normal. Furthermore, the accumulation location of the injected-water in pork could be visualized by MRI. Therefore, LF-NMR combined with MRI offers an effective method for the detection of water-injected pork.
Crystal structure of diaqua-bis(1,10-phenanthroline κ2
N,N′)nickel(II) trifluoroacetate- trifluoroacetic acid (1/1), C30H21F9N4NiO8
Authors: Zhang Lan , Wang Qiang , Ding Wu-Xiu , Hao Hui-Min 
Published: June 2019

Abstract
C30H21F9N4NiO8, monoclinic, P21/c (no. 13), a = 10.0630(11) Å, b = 9.625(1) Å, c = 18.196(2) Å, β = 116.10(3)°, V = 1582.7(5) Å3, Z = 2, R
gt(F) = 0.0511, wR
ref(F
2) = 0.1261, T = 293(2) K.
Proficiency testing as a tool to assess quality of data: the experience of the EU Reference Laboratory for chemical elements in food of animal origin
Authors: Sorbo Angela , Ciprotti Maria , Colabucci Andrea , D’Amato Marilena , Di Gregorio Marco , Luswergh G. Fornari , Turco Anna C. , Ciaralli Laura 
Published: June 2019

Abstract
Quality and reliability of analytical results are, in general, key issues for all laboratories but become a top priority for laboratories accredited according to ISO/IEC 17025:2005. In this international standard the proficiency testing (PT) is regarded as a means to assure the validity of results. Nowadays, the proved competence of laboratories is an essential requirement especially for that structures that are involved in the official controls aimed at ensuring the safety of EU food products and the public health. To guarantee the EU consumers, the Council and the Commission have designated 28 European Union Reference Laboratories (EURLs) for food and feed, whose main role is to contribute to the standardization of analytical methods and to the harmonization of performance among the EU National Reference Laboratories (NRLs) to reach a comparable level of quality in the analytical data among all Member States. With this aim, the organization of PTs is a task that each EURL has to accomplish. Over the last 15 years, the EURL for chemical elements in food of animal origin (EURL-CEFAO) have organized 32 PTs on determination of total As, Cd, Pb and total Hg in meat, milk, fish and offal for the benefit of its network of NRLs. Some specific aspects of this activity will be discussed (e.g. preparation and characterization of PT materials, statistical evaluation of data, follow-up actions). Finally, based on the EURL-CEFAO experience, it will be demonstrated that the participation into PTs on a regular basis can result in an improvement of the laboratory’s performance as well as in the harmonization of the results submitted by participants.
The Supply Network and Price Dispersion in the Canadian Gasoline Market
Authors: Malloy Brandon 
Published: June 2019

Abstract
This paper examines the impact of variation in transportation options – what I denote the “supply network” – on observed price differences between locations for a specific good, retail gasoline. I use a unique data set of weekly gasoline prices across 44 Canadian cities to analyze how the existence of variation in the available modes of transportation for gasoline between cities (via pipeline, marine tanker, rail or truck) accounts for observed price differences across locations. I find that the supply network is significant – cities connected by lower cost-per-unit methods like pipelines or seaports exhibit smaller mean- and weekly-price differences than those connected only by road or rail, after controlling for distance, regional effects and market size. A pipeline connection results in a reduction in weekly price dispersion equivalent to a 53% reduction in distance between cities, while a maritime connection has the equivalent effect of a 38% reduction in distance between cities.
Deep-learned faces of pain and emotions: Elucidating the differences of facial expressions with the help of explainable AI methods
Authors: Weitz Katharina , Hassan Teena , Schmid Ute , Garbas Jens-Uwe 
Published: June 2019

AbstractDeep neural networks are successfully used for object and face recognition in images and videos. In order to be able to apply such networks in practice, for example in hospitals as a pain recognition tool, the current procedures are only suitable to a limited extent. The advantage of deep neural methods is that they can learn complex non-linear relationships between raw data and target classes without limiting themselves to a set of hand-crafted features provided by humans. However, the disadvantage is that due to the complexity of these networks, it is not possible to interpret the knowledge that is stored inside the network. It is a black-box learning procedure. Explainable Artificial Intelligence (AI) approaches mitigate this problem by extracting explanations for decisions and representing them in a human-interpretable form. The aim of this paper is to investigate the explainable AI methods Layer-wise Relevance Propagation (LRP) and Local Interpretable Model-agnostic Explanations (LIME). These approaches are applied to explain how a deep neural network distinguishes facial expressions of pain from facial expressions of emotions such as happiness and disgust.
Detecting the Flow Pattern Transition in the Gas-Liquid Two-Phase Flow Using Multivariate Multi-Scale Entropy Analysis
Authors: Liu Yudong , Wang Dayang , Ren Yingyu , Jin Ningde 
Published: June 2019

Abstract
Due to the complex flow structure and non-uniform phase distribution in the vertical upward gas-liquid two-phase flow, an eight-electrode rotating electric field conductance sensor is used to obtain multi-channel conductance signals. The flow patterns of the vertical upward gas-liquid two-phase flow are classified according to the images obtained from a high-speed camera. Then, we employ the multivariate weighted multi-scale permutation entropy (MWMPE) to detect the instability of flow pattern transition in the gas-liquid two-phase flow. Afterwards, we compare the results of the MWMPE with those of the single-channel weighted multi-scale permutation entropy (SCWMPE) and multivariate multi-scale sample entropy (MMSE). The comparison results indicate that, compared with the SCWMPE and MMSE, the MWMPE has superior performance in terms of the high-resolution presentation of flow instability in the gas-liquid two-phase flow. Finally, we extract the mean value of the MWMPE in whole scales and the entropy rate of the MWMPE in the small scales. The results indicate that the normalized mean value and normalized entropy rate of MWMPE are very sensitive to the transitions of flow patterns, thus allowing the detection of the instability of flow pattern transition.