bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trauma‐informed primary care for medical residents
Authors: Shamaskin‐Garroway Andrea M , McLaughlin Elizabeth A , Quinn Noel , Buono Frank D 
Published: August 2019

SummaryBackgroundPsychological trauma can have a significant impact on mental and physical health, and interpersonal relationships. Many physicians report discomfort addressing psychological trauma in the context of health care visits, and few training opportunities exist for health care trainees to learn about the relationship between trauma and health. The aim of this project was to develop and implement an educational curriculum to teach medical and nursing trainees about trauma‐informed primary care.MethodsWe expanded upon pilot data from a brief interdisciplinary intervention to train medical residents in trauma‐informed primary care at a Veterans Affairs hospital. We generated a trauma‐informed care curriculum involving five 1‐hour didactic sessions, 10‐minute group reflection regarding patient interactions prior to each didactic session, and optional patient care observation and feedback. The curriculum aligned with internal medicine (n = 16) and nurse practitioner (n = 5) interprofessional primary care education sessions during the 2017/18 academic year.ResultsThe curriculum was feasible and associated with increased self‐reported knowledge, attitudes and practice around trauma‐informed care. Free text feedback indicated that residents found the topic important, appreciated a skills‐based approach and valued experiential educational activities.ConclusionsTraining residents in trauma‐informed care results in improved knowledge, attitudes and practices in caring for patients with psychological trauma. Residents appreciated both experiential and skills‐based exercises. Next steps include continued exploration of using direct observation and feedback, and examining effects of training on patient outcomes (e.g. satisfaction with care).
In Her Shoes: Transnational Digital Solidarity With Muslim Women, or the Hijab?
Authors: Rahbari Ladan 
Published: August 2019

AbstractTransnational solidarity has been taken up by feminist scholars, social scientists and activists who discuss or practice solidarity with the plights of different individuals, groups, and communities. This paper addresses transnational solidarity by investigating World Hijab Day, a campaign that shows solidarity with Muslim women by encouraging non‐Muslim women to temporarily wear the hijab. By analysing online activities and social media of the campaign, and investigating public debates surrounding it, the paper explores the centrality of the hijab as the unifying symbol. Results include reflections on the representations of female Muslimness, the hijab and gender roles in the campaign and insights on implications and possibility of transnational digital solidarity. Using the data, and drawing on literature of transnational solidarity, significance and implications of transnational activism in different online and digital geographies of solidarity are interrogated. The conclusion discusses the values and limits of solidarity activism that is based on notions or symbols of similarity or sameness and the role cyberspace plays in transnational reach of the campaign, and in creating online proximity.
A case of immune reconstitution syndrome complicating progressive multifocal leukoencephalopathy after kidney transplant: Clinical, pathological, and radiographic features
Authors: Jackowiak Eric , Shah Nirav , Chen Huiwen , Ojha Ajitesh , Doyle John , Shepler Anne , Bogdanovich Tatiana , Silveira Fernanda P. , Haidar Ghady 
Published: August 2019

AbstractProgressive multifocal leukoencephalopathy (PML) is a life‐threatening central nervous system (CNS) disorder, most commonly described in patients infected with the human immunodeficiency virus (HIV). Limited data exist on its natural history and treatment in solid organ transplant (SOT) recipients. A complication of PML is the immune reconstitution inflammatory syndrome (IRIS), which develops after T cell reconstitution and can have severe consequences when it occurs in the CNS. While well described in HIV‐infected individuals, its clinical features, diagnosis, and treatment after SOT are largely unknown. We report a case of a kidney transplant recipient who was diagnosed with PML and developed significant worsening of her symptoms upon reduction of immunosuppression. Thallium SPECT showed avid uptake suggestive of lymphoma, but the diagnosis of PML‐IRIS was ultimately established by brain biopsy. She survived with nearly complete restoration of her functional status after a prolonged steroid taper.
Claudins in the brain: Unconventional functions in neurons
Authors: Tikiyani Vina , Babu Kavita 
Published: August 2019

AbstractBonafide claudin proteins are functional and structural components of tight junctions and are largely responsible for barrier formation across epithelial and endothelial membranes. However, current advances in the understanding of claudin biology have revealed their unexpected functions in the brain. Apart from maintaining blood‐brain barriers in the brain, other functions of claudins in neurons and at synapses have been largely elusive and are just coming to light. In this review, we summarize the functions of claudins in the brain and their association in neuronal diseases. Further, we go on to cover some recent studies that show that claudins play signaling functions in neurons by regulating trafficking of postsynaptic receptors and controlling dendritic morphogenesis in the model organism Caenorhabditis elegans.
Ultrasonographic differentiation between portal venous and parenchymal gas may be important for the prognosis of canine and feline hepatic emphysema: 37 cases
Authors: Manfredi Sabrina , Fabbi Martina , Bonazzi Mattia , Leonardi Fabio , Miduri Francesca , Parroccini Ilaria , Daga Eleonora , Gnudi Giacomo , Volta Antonella 
Published: August 2019

AbstractThe aim of this retrospective, cross‐sectional, study was to evaluate clinical findings and outcomes for different ultrasonographic patterns of hepatic emphysema in dogs and cats. Dogs and cats with an ultrasonographic diagnosis of hepatic emphysema and a known outcome, from January 2010 to January 2018, were enrolled. The following data were recorded from medical and ultrasonographic records: ultrasonographic patterns of hepatic emphysema (parenchymal, portal venous, biliary), clinical signs, laboratory findings, and outcomes (favorable, poor). A total of 33 dogs and four cats met the inclusion criteria. Among these, 23 cases were classified as hepatic portal venous gas, 10 as parenchymal emphysema, and four as biliary emphysema. Clinical diagnosis categories were as follows: infection/sepsis (9), gastro‐intestinal disease (9), iatrogenic (9), trauma (5), and liver neoplasia (5). An increase in serum liver enzymes was significantly associated with parenchymal emphysema (P = .03). Other clinical and laboratory findings were not associated with the type of hepatic emphysema. Hepatic portal venous gas was mostly transient in patients with ultrasonographic follow‐up. The overall mortality was 40.5%. A significant difference was found between mortality by portal venous gas (21.7%) and mortality by parenchymal emphysema (90%) (P = .003). In conclusion, the ultrasonographic differentiation of hepatic emphysema between hepatic portal venous gas and parenchymal emphysema may be important for the prognosis of hepatic emphysema. The presence of parenchymal emphysema may be a poor prognostic indicator, while hepatic portal venous gas may be more benign. However, ultrasound findings should be carefully evaluated in the context of clinical findings.
Strontium isotope stratigraphy and paleomagnetic age constraints on the evolution history of coral reef islands, northern South China Sea
Authors: Fan Tianlai , Yu Kefu , Zhao Jianxin , Jiang Wei , Xu Shendong , Zhang Yu , Wang Rui , Wang Yinghui , Feng Yuexing , Bian Lizeng , Qian Handong , Liao Weihua 
Published: August 2019

Abstract
Understanding the history of the response of coral reefs to past climate changes can provide valuable information for predicting the future response of modern reefs. However, dating such ancient biotic carbonate is still challenging because of its sensitivity to diagenetic alteration processes, scarcity of well-preserved fossils, and low magnetic mineral content. There have been a long debates about the origin and evolutionary history of coral reefs in the northern South China Sea, mainly due to the lack of direct and reliable age constraints. This provides us with a good opportunity to verify the practicability of different dating approaches, especially the strontium (Sr) isotope analysis of bulk carbonate. Here, we retrieved a 972.55-m-long core from the Xisha Islands to provide a credible chronologic constraint on the carbonate platform evolution. The lithostratigraphy, strontium isotope stratigraphy, and magnetostratigraphy were analyzed throughout the whole reef sequence. The lithostratigraphic results show that the 873.55 m reef sequence developed on an ancient volcaniclastic basement and experienced multiple evolutionary phases. The 87Sr/86Sr results of all 100 bulk carbonate samples vary from 0.708506 to 0.709168 and show a monotonic increase with decreasing depth, except for a few outliers. Trace-element criteria and stable isotope (δ18O and δ13C) methods were applied to these bulk carbonate samples, and results imply that the primary or near-primary seawater 87Sr/86Sr values were likely preserved, although different degrees of diagenetic alteration occurred. In addition, the paleomagnetic results indicate 10 normal polarity and eight reversed polarity magnetozones. Based on the 87Sr/86Sr ratios of the selected 58 samples and paleomagnetic reconstruction of polarity reversals, the bottom of the reef sequence is dated to 19.6 Ma, and the observed polarity chronozones extend from chron C6 (19.722–18.748 Ma) at 866.60 m to present at the top. Based on the new data, we propose a new chronologic framework for the evolutionary history of the reef islands, where: (1) the reefs initiated in the early Miocene (19.6 Ma) and were drowned until 16.26 Ma; (2) during 16.26–10.66 Ma, lagoon to lagoon slope environments prevailed; (3) the lagoon environment progressively transformed into a reef crest environment from 10.66 to 4.36 Ma and 4.36 to 1.59 Ma; and (4) the reef started to be drowned again during 1.59–0 Ma. Our study provides a new and reliable chronologic constraint on the general evolutionary history of the reef islands in the northern South China Sea. Furthermore, the 87Sr/86Sr results from bulk carbonate indicate that strontium isotope stratigraphy is a powerful dating tool only when rigid sample selection, sequential leaching procedures, and strict trace-element and isotopic criteria are applied.
Linking metamorphism, magma generation, and synorogenic sedimentation to crustal thickening during Southern Appalachian mountain building, USA
Authors: Stowell H.H. , Schwartz J.J. , Ingram S.B. , Madden J. , Jernigan C. , Steltenpohl M. , Mueller P. 
Published: August 2019

Abstract
The nature of metamorphism, magma compositions, the spatial distribution of plutons, and foreland sediments reflect, in part, the character and thickness of continental crust. We utilized metamorphic pressure-temperature-time (P-T-t) paths, garnet Sm-Nd ages, zircon U-Pb ages, and pluton compositions to estimate paleocrustal thickness and temporal changes in crustal magma sources in the Blue Ridge of the southernmost Appalachians. Garnet Sm-Nd ages for amphibolite-facies metamorphic rocks range from 331 ± 4 to 320 ± 3 Ma. Low- and high-Sr/Y plutons that intruded these metamorphic rocks have zircon U-Pb ages of 390 ± 1 to 365 ± 1 Ma and 349 ± 2 to 335 ± 1 Ma, respectively. Therefore, garnet growth began during regional metamorphism synchronous with or shortly after intrusion of the youngest high-Sr/Y trondhjemite plutons. Phase diagram sections and thermobarometry indicate that garnet growth initiated at ∼5.8 kbar and 540 °C and grew during temperature increases of 60–100 °C and pressure increases of 2–3 kbar. The older, low-Sr/Y magmas are inferred to have been sourced in the crust at depths <∼30 km, insufficient for garnet to be stable. However, the younger, high-Sr/Y magmas are inferred to have been sourced at >30 km depths where garnet was stable. Hafnium isotopic compositions for all the plutons, but one, exhibit a range from negative initial εHf(i) to weakly positive initial εHf(i), indicating incomplete mixing of dominantly crustal sources. Our data require minimum crustal thicknesses of ∼33 km at 331 Ma; however, Alleghanian crustal thicknesses must have locally reached 39 km, based on crustal reconstruction adding the Alleghanian thrust sheet beneath the eastern Blue Ridge. We infer the presence of hot, tectonically thickened crust during intrusion of the early Alleghanian high-Sr/Y plutons and conclude that garnet growth and plutonism reflect a progressive increase in crustal thickness and depth of magma generation. The crustal thickening was synchronous with deposition of Mississippian to early Pennsylvanian sediments in the foreland basin of the Appalachian orogen between 350 and 320 Ma. This crustal thickening may have preceded emplacement of the Alleghanian thrust sheets onto the North American craton.
Research gaps in the organisation of primary healthcare in low-income and middle-income countries and ways to address them: a mixed-methods approach
Authors: Goodyear-Smith Felicity , Bazemore Andrew , Coffman Megan , Fortier Richard D W , Howe Amanda , Kidd Michael , Phillips Robert , Rouleau Katherine , van Weel Chris 
Published: August 2019

IntroductionSince the Alma-Ata Declaration 40 years ago, primary healthcare (PHC) has made great advances, but there is insufficient research on models of care and outcomes—particularly for low-income and middle-income countries (LMICs). Systematic efforts to identify these gaps and develop evidence-based strategies for improvement in LMICs has been lacking. We report on a global effort to identify and prioritise the knowledge needs of PHC practitioners and researchers in LMICs about PHC organisation.MethodsThree-round modified Delphi using web-based surveys. PHC practitioners and academics and policy-makers from LMICs sampled from global networks. First round (pre-Delphi survey) collated possible research questions to address knowledge gaps about organisation. Responses were independently coded, collapsed and synthesised. Round 2 (Delphi round 1) invited panellists to rate importance of each question. In round 3 (Delphi round 2), panellists ranked questions into final order of importance. Literature review conducted on 36 questions and gap map generated.ResultsDiverse range of practitioners and academics in LMICs from all global regions generated 744 questions for PHC organisation. In round 2, 36 synthesised questions on organisation were rated. In round 3, the top 16 questions were ranked to yield four prioritised questions in each area. Literature reviews confirmed gap in evidence on prioritised questions in LMICs.ConclusionIn line with the 2018 Astana Declaration, this mixed-methods study has produced a unique list of essential gaps in our knowledge of how best to organise PHC, priority-ordered by LMIC expert informants capable of shaping their mitigation. Research teams in LMIC have developed implementation plans to answer the top four ranked research questions.
Primary care financing: a systematic assessment of research priorities in low- and middle-income countries
Authors: Goodyear-Smith Felicity , Bazemore Andrew , Coffman Megan , Fortier Richard , Howe Amanda , Kidd Michael , Phillips Robert , Rouleau Katherine , van Weel Chris 
Published: August 2019

IntroductionFinancing of primary healthcare (PHC) is the key to the provision of equitable universal care. We aimed to identify and prioritise the perceived needs of PHC practitioners and researchers for new research in low- and middle-income countries (LMIC) about financing of PHC.MethodsThree-round expert panel consultation using web-based surveys of LMIC PHC practitioners, academics and policy-makers sampled from global networks. Iterative literature review conducted in parallel. First round (Pre-Delphi survey) elicited possible research questions to address knowledge gaps about financing. Responses were independently coded, collapsed and synthesised to two lists of questions. Round 2 (Delphi Round 1) invited panellists to rate importance of each question. In Round 3 (Delphi Round 2), panellists ranked questions in order of importance.ResultsA diverse range of PHC practitioners, academics and policy-makers in LMIC representing all global regions identified 479 knowledge gaps as potentially critical to improving PHC financing. Round 2 provided 31 synthesised questions on financing for rating. The top 16 were ranked in Round 3e to produce four prioritised research questions.ConclusionsThis novel exercise created an expansive and prioritised list of critical knowledge gaps in PHC financing research questions. This offers valuable guidance to global supporters of primary care evaluation and implementation, including research funders and academics seeking research priorities. The source and context specificity of this research, informed by LMIC practitioners and academics on a global and local basis, should increase the likelihood of local relevance and eventual success in implementing the findings.
Patients’ information needs and attitudes about post-treatment surveillance for colorectal cancer in the United States: a multi-perspective, mixed methods study
Authors: Lowenstein Lisa M , Volk Robert J , Cuddy Amanda , Hempstead Andrea P , You Y Nancy , Van Loon Katherine , Millas Stefanos , Meyerhardt Jeffrey A , Gavin Patrick , Chang George J 
Published: August 2019

ObjectiveWe sought to determine patients’ informational needs for post-treatment surveillance and elicit clinicians’ and patient advocates’ (ie, stakeholders) opinions regarding what patients should know about post-treatment surveillance in the USA.DesignA mixed-methods study, using semi-structured interviews followed by a survey study.SettingParticipants for the interviews were from two large academic medical centres and a safety-net hospital. The stakeholders were recruited from attendees at the Alliance for Clinical Trials in Oncology Network Spring 2016 meeting.ParticipantsParticipants for the in-depth interviews were purposively sampled. Eligible patients were 6 months to 5 years post curative resection for colorectal cancer and were fluent in English. Participants for the anonymous survey were stakeholders.Main outcome(s) and measure(s)The main outcome was patients’ with colorectal cancer informational needs for post-treatment surveillance, using an interview guide. The second outcome was the importance of the identified informational needs using an anonymous survey.ResultsOf the 67 patients approached, 31 were interviewed (response rate=46%), the majority were between 1 and 3 years post-treatment (81%) and diagnosed at stage III (74%). Despite a desire to monitor for cancer recurrence, patients had little understanding of the concept of post-treatment surveillance, equating surveillance with screening and a belief that if a recurrence was found early there would be a higher likelihood of cure. The survey suggested that clinicians (n=38) and patient advocates (n=11) had some differing opinions regarding what patients should know about surveillance to be active in decisions. For example, compared with clinicians, patient advocates felt that patients should know recurrence treatment options (100% vs 58%) and likelihood for cure following recurrence treatment (100% vs 38%).ConclusionsThe results of this exploratory mixed-methods study suggest that novel educational interventions targeting both patients and clinicians are needed to address the informational needs for post-treatment surveillance of colorectal cancer.
Psychometrics properties of the Team Interaction Scale and influencing factors of team interaction of tertiary hospital physicians in China: a cross-sectional study
Authors: Song Wenwen , Li Honghe , Ding Ning , Zhao Weiyue , Shi Lin , Wen Deliang 
Published: August 2019

ObjectivesTo administer a cross-cultural adaptation of the Team Interaction Scale (TIS), test its psychometric properties and investigate influencing factors of team interactions in a physician population in Chinese tertiary hospitals.DesignCross-sectional survey.SettingsTwo rounds of surveys, a pilot and a large sampling survey, were conducted in two and nine tertiary hospitals, respectively, in Liaoning Province, China.ParticipantsIn the pilot survey, 363 of 390 physicians sampled were included in the analysis, resulting in an effective response rate of 93.08%. In the large sampling survey, the effective response rate was 89.10% (3653 of 4100 physicians).Outcome measuresThe TIS and a short version of a burn-out scale were administrated to assess the physician’s team interaction and burn-out. Psychometric properties of TIS were tested by confirmatory factor analysis (CFA), exploratory factor analysis (EFA) and internal consistency analysis. Gender, age, discipline, education level, professional title, hospital scale and burn-out were explored as influencing factors with independent samplet-tests, one-way analyses of variance and a correlation analysis.ResultsBased on CFA, a 17-item modified scale was developed following the pilot survey. In the large sampling survey, EFA was conducted with half of the samples, producing six dimensions: ‘Communication’, ‘Coordination’, ‘Mutual help’, ‘Team goals’, ‘Work norms’ and ‘Cohesion and conflict resolution’. Fit of the modified model was confirmed by CFA with the other half of the samples (root mean square error of approximation=0.067, Comparative Fit Index=0.98, Normed Fit Index=0.97, Goodness of Fit Index=0.94, Adjusted Goodness of Fit Index=0.92). A high Cronbach’s α coefficient of 0.98 demonstrated reliability of the modified scale. The Team Interaction Score was significantly lower in younger physicians, in men, in paediatricians and in physicians from larger-scale tertiary hospitals. Team Interaction Scores were negatively associated with burn-out.ConclusionsThe adapted TIS, containing 17 items and six dimensions, was reliable and valid for Chinese tertiary hospital physicians. To address physician burn-out, team interaction should be highlighted.