bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obesity, Dyslipidemia and Insulin Resistance in Survivors of Childhood Cancer
Authors: Mahalingam MD Soundarya , MD Kamalakshi G Bhat , MBBS Anita Dhulipalli , Ramaswamy MD Saravanan 
Published: January 2019

Abstract
Background: With the increased survival rates following the treatment of childhood cancer, it becomes equally important that the need for evidence based surveillance of long term effects of cancer therapy is addressed. This includes the risk of development of metabolic syndrome features like obesity, altered lipid and sugar profile, which was attempted in the present study.
Materials and Methods: In this cross sectional case study, 50 survivors of childhood cancer aged between 5 – 18 years were recruited. Positive history of obesity, diabetes mellitus, dyslipidemia, and stroke in family were recorded and their anthropometry was noted with calculation of their Body Mass Index (BMI). Fasting lipid profile, blood sugar, and serum insulin levels were tested; the Homeostatic model assessment of Insulin Resistance (HOMA IR) value and the Fasting Glucose to Insulin Ratio(FGIR) were derived as markers of insulin sensitivity. The data were analyzed using SPSS (version 17.0).
Results: In these fifty children, the risk factors studied for dyslipidemia and insulin resistance due to chemotherapy were: age at diagnosis, sex, radiation exposure, steroid, and L-asparaginase use during the treatment for cancer. Among the fifty survivors, 7 were found obese, 32 normal, and 11 underweight as per the age specific BMI charts. Their metabolic parameters showed that 12 had raised cholesterol levels, 8 had raised triglyceride levels, and 4 had lowered HDL-C levels. Nine survivors also had raised HOMA-IR levels. However, these metabolic derangements were not found to be statistically significant (p value>0.05) and no correlation was found between the risk factors and obesity, dyslipidemia, or insulin resistance.
Conclusion: As against the prior evidence, there was no risk of developing obesity, dyslipidemia, and insulin resistance in survivors of childhood cancers.
Keywords: Dyslipidemias, Insulin Resistance, Obesity, Survivors of childhood cancer
Antibiotic induced hemolytic anemia and thrombocytopenia among pediatric patients admitted to intensive care unit
Authors: MD Hassan Taherahmadi , MSc Ali Reza Moradabadi , MD Ali Arjomand shabestari , MD Javad Nazari , MD Manijeh Kahbazi 
Published: January 2019

Background: Drug induced hemolytic anemia and thrombocytopenia (DIHA and DIT) are common drug adverse effects of antibiotics in patients admitted to hospital. This reaction is important in patients who have a chronic disease especially in pediatrics. In this study, possible hemolytic anemia was investigated before and after the antibiotics administration.
Materials and Methods: A total of 835 children were investigated in this retrospective study. The laboratory tests were performed before and at least one week after antibiotics administration. The red blood cell (RBC), platelet (plt), hematocrit (Hct), and hemoglobin (Hb) were measured.
Results: With respect to age, 76.11% of studied patients were under 6 years old. The others were between 6-10 years (mean 5.38 years). The two tailed T tests results on the patients’ information showed a difference between RBC, platelet, hematocrit, and hemoglobin values before and after antibiotics administration to the point where the RBC mean counts before and after administration were 4.53 to 3.82 *1012/L, respectively. These changes for plt, Hb, and Hct were 323.5 to 232.5 *109/L, 13.61 to 11.46 mg/dL, and 40.83 to 34.38 %, respectively. The p-values were 0.000025, 0.000051, 0.000061, and 0.000032 for RBC, platelet, hematocrit, and hemoglobin; respectively. This finding confirmed that antibiotics administration can decrease the platelets and RBC count. The antibiotics used in the children were ceftriaxone (38.2%), clindamycin (23.3%), Clarithromycin (19.6%), and acyclovir (12.1%); respectively. The dose of the ceftriaxone varied from 50 mg/kg to 70 mg/kg in shigelloses and pneumonia, respectively. Additionally, clindamycin, clarithromycin, and acyclovir were prescribed for 10 mg/kg, 5-10, and 10 mg/kg per day; respectively.
Conclusion: This study showed that antibiotics administration had adverse effects and should be considered when they are prescribed to children with chronic diseases. The physicians should be awarded about proper dosing to decrease adverse effects.
Keywords: Anti-Bacterial Agents, Drug-Related Side Effects, Adverse Reactions, Hemolytic Anemia, Pediatric, Thrombocytopenia
PERBEDAAN KECERDASAN EMOSIONAL DILIHAT DARI PILIHAN SESEORANG SAAT BERHADAPAN DENGAN DILEMA MORAL AGAMA
Authors: Hani Lutfiyah , Hafiz Subhan El 
Published: January 2019

Aim of this research to see difference of emotional intelligence from one's choice when faces dilemmas situation of religious value. This research using quantitative approach method and subject of this study for respondents aged 17-50 years and Muslim as many as 153 respondents. The measurement instruments are the emotional intelligence scale, “trait meta-mood scale” (TMMS) and dilemmas situation instrument. Data analyzed by compare mean t-test independent sample. The results shows no difference of emotional intelligence seen from individual reasons to decide their choices, namely emotional and rational (MD=0.710; p>0.05). But when the data analyzed based on groups choice the results shows significant difference in emotional intelligence seen from group which choose not to do plural prayer (jama’), which is higher emotional intelligent in a group who choose with rasional reason than emotional (MD=0.047; p<0.05). Hypoteses also rejected in group which choose rukhsoh (MD=0.313; p>0.05). This resuls shows emotional intelligent can affecting the reason one to choose but limited to certain type of choosen.
Identification of Toxoplasma Gondii Cyst in Ras Chicken as A Potential Infection of Toxoplasmosis
Authors: Avin Farisa Al Amin , Melaniani Soenarnatalina 
Published: January 2019

Toxoplasmosis is a zoonotic diseases caused by Toxoplasma gondii,which spread out by cats and it can be found in fowl. It because the fowl swallowing food which had been infected byToxoplasma gondii oocyst. The most consumpted fowl is chicken.The source of data and agriculture information center showed that consumption of chicken was increased about 10,20%. It could be a potential increasement of Toxoplasma gondii infection. The objective of this research was indentificate the infection of Toxoplasma gondii cyst on ras chicken brain. The type of this research was a descriptive research, observe by examining 30 samples of the ras chicken brain by randomized sampling techniques. Based on research on 30 samples of the ras chicken brain, obtained positive results as much as 2 samples (6.6%) cyst infected of Toxoplasma gondii and others 28 samples of ras chicken brain (93.4%) were not infected with Toxoplasma gondii cysts. Positive results of Toxoplasma gondii can be caused due to maintenance system and cleanliness of chicken coop was much less, so there were carrier vectors contaminate to feed place, so there was a potential infection of Toxoplasmosis.It can be concluded that been 2 samples of chicken brain being infected cyst of Toxoplasma gondii or about 6,6% and there were 28 samples or 93,4% of chicken brain that were not infected by cyst of Toxoplasma gondii. Infection circle of Toxoplasmosis can be avoided by manage maintenance system of chicken and keep the cage cleamliness, also keep the personal hygiene and feeds.
Environmental Management Physical Conditions and Complaints in The Health Workers in The Garment Production Gresik
Authors: Baswedan Sajidah , Sulistyorini Lilis 
Published: January 2019

Abstract: Physical conditions in the work environment is something that must be kept clean, because if the environmental conditions are not good, then it will result in the workers’ health. This study aims to determine whether the management of the physical environmental conditions in the garment production in Gresik are in accordance with the Decree of the Minister of Health of the Republic of Indonesia Year 2002 Number 1405 About the Job Requirements Environmental Health Office and Industrial. This research uses descriptive and observational study using evaluative method. The results of the study will be treated descriptively. This study used a cross sectional approach. Sample size is 50 people who are working in garment production space in Gresik are taken randomly using simple random sampling. Obtained result is said to be good for the environment and are eligible for health complaints while ineligible said. Sheet observation shows that there are still some things about the application of the physical environmental conditions that are less in accordance with the regulations, among others, waste, noise, and toilet. Management of the physical environmental conditions in garment production space in Gresik can be categorized in accordance with applicable regulations.Keywords: physical conditions, health complaints
Hygiene Sanitation, Phisical Qualities and Bacterial in Fresh Cow’s Milk of X Milk Company in Surabaya
Authors: Navyanti Feryalin , Adriyani Retno 
Published: January 2019

Abstract: Fresh cow’s milk consumed by many people so that the quality must be maintained so that people can safely consume. This study was conducted to identify the state of hygiene and sanitation measures the quality of fresh cow’s milk dairies X in Surabaya. This study is a descriptive study, with a cross sectional design. Data collection sanitary hygienic milk performed using observations corporate environment. Interviews with owners and cow milker. The existence Escherecia coli in fresh cow’s milk was tested by using the MPN method. The presence of the bacteria tested with Total Plate count method. Physical quality is measured by means of sensory. The results showed that the sanitation in the milk Milk Company X included in the category are not eligible. Variables that have not met the requirements of health and hygiene milker, cow health and hygiene, health and hygiene cage. The quality of fresh cow’s milk in terms of bacteriological content of escherechia coli negative while for the Total Plate Count parameter ranges 5,4 × 103 CFU/ml - 67,5 × 104 CFU / ml. Physical qualities which include the color white, the typical smell of milk and sweetened slightly salty. The conclusion that can be drawn is sanitary hygiene while still qualify from the bacteriological quality, Total Plate Count parameters and the presence of Escherechia coli 01.3141.1998 meet the requirements of SNI and SNI 3141.01.2011. In order to improve the quality of milk produced before milking cows should always be washed first and milked milk should be placed in containers or milk can is sealed to avoid contamination.Keywords: Total Plate count, Escherichia coli, sanitary higiene of dairy milk
Characteristic, Levels of lead in the blood, and hypertension of Workers Batteries Home Industry at Talun Village Sukodadi District Lamongan Regency
Authors: Fibrianti Lian Dwi , Azizah R. 
Published: January 2019

Abstract: Lead (Pb) is one of the pollutants that can cause hypertension. The objectives of this study were to analyze characteristic, levels of Lead (Pb) in blood and hypertension at home industry workers batteries. This research was an observational descriptive studies and used cross-sectional approach. Data obtained from interviews, questionnaires, and observation. Measurement of blood lead used Atomic Absorption Spectrophotometer and blood pressure measurements used a tensimeter. Samples were selected by total population of 10 workers batteries home industry. The results of the research that most workers age is less than 30 years was 50%, the worker men was 60%, workers who have a habit of smoke was 30%, Pb levels in the blood of workers 30% above the standards set by ATSDR (1999) < 10 μg/dL, and 40% of workers have hypertension. Cross-tabulation showed that workers who have hypertension that workers aged 31–40 years (50%), workers with employment ≤ 5 year period (40%), male workers (66.7%), workers who was smoke (100%), workers with no history of hypertension and diabetes (40%) and workers who have levels of lead (Pb) in the blood > 10 μg/dL (100%). Advise the workers to reduce cigarette consumption and wear personal protective equipment such as masks, gloves and boots while they work to reduce exposure of lead (Pb).Keywords: characteristic of workers, levels of lead (Pb) in the blood, hypertension, workers home industry batteries
Impact Analysis of Noise Intensity with Hearing Loss on Laundry Worker
Authors: Dewanty Rindy Astike , Sudarmaji Sudarmaji 
Published: January 2019

Abstract: Laundry unit at a hospital can be a source of noise. The impact was very dangerous for workers, especially against hearing. From the results of a preliminary survey of the noise intensity measurements obtained intensity noise of 81.2 dB (A). The purpose of this study was to analyze the effects of noise on hearing loss intensity laundry attendant. This study was an observational with cross sectional design. The instrument used was a questionnaire to see the characteristics of the respondent, sound level meter to measure the intensity of noise and audiometry test to measure the threshold of hearing respondents. The research subject as many as 16 workers of laundry. Based on the results of the study states that 75% of the existing work in the laundry unit has a noise intensity exceeds the required value and 12 officers were on the section. The measurement results with minimum of 65.4 dB (A), to a maximum of 84.0 dB( A) andthe average intensity of noise by 79.04 dB (A). Obtained eight workers (50%) had hearing loss right ear and 6 offi cers (37.5%) had hearing loss left ear. There was a relationship between impaired right ear with noise intensity (Spearman; r = 0.577). The need hearing health for periodic examination least once a year, reducing device noise to keep the noise source, and personal protective equipment (PPE).Keywords: hearing loss, intensity noise, laundry
DELIK PENCEMARAN NAMA BAIK YANG DILAKUKAN OLEH ADVOKAT DALAM MELAKSANAKAN TUGASNYA SEBAGAI KUASA KLIEN
Authors: Fanani Mohamad Adnan 
Published: January 2019

Setiap orang memiliki rasa harga diri mengenai kehormatan dan rasa harga diri mengenai nama baik. Tindak pidana penghinaan (beleediging) yang dibentuk oleh pembentuk undang-undang, baik yang bersifat umum, maupun yang bersifat khusus, ditujukan untuk memberi perlindungan bagi kepentingan hukum mengenai rasa semacam ini. Tentang tindak pidana penghinaan (pencemaran nama baik), ada yang merupakan penghinaan umum dan ada penghinaan khusus yang diatur dalam KUHP.Tesis ini menggunakan metode penelitian normatif dengan mengkaji pengaturan hukum mengenai tindak pidana pencemaran nama baik. Sumber data yang digunakan dalam tesis ini adalah data sekunder dan digolongkan atas bahan hukum primer yang terdiri dari KUHP, Undang-Undang Nomor 18 Tahun 2003 Tentang Advokat dan UU No. 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik, bahan hukum sekunder yang terdiri dari buku – buku dan peraturan perundang-undangan yang berhubungan dengan pertanggungjawaban pidana dalam hal surat yang berindikasi adanya delik pencemaran nama baik yang dilakukan oleh advokat dalam melaksanakan tugasnya sebagai kuasa klien. Dikarenakan penelitian ini merupakan penelitian normatif maka metode pengumpulan data yang digunakan adalah dengan studi Pendekatan Perundang-Undang an (Statute Approach) dan pendekatan konseptual ( Conceptual Approach). Analisis data yang digunakan dalam penelitian ini menggunakan analisis data kualitatif. Dengan penulisan ini diharapakan dapat bermanfaat dan menambah pengetahuan bagi para pembacanya.
Immediate results of combined and multivisceral resections for rectal cancer
Authors: Afanasyev S. G. , Dobrodeev A. Yu. , Khadagaev I. B. , Fursov S. A. , Usynin E. A. , Tarasova А. S. , Sorokin D. A. , Faltin V. V. , Usova A. V. 
Published: January 2019

Background.Currently, the indications for multivisceral pelvic resections have increased dramatically. However, short-and long-term outcomes after these resections for locally advanced rectal cancer remain a subject of debate.The purposeof the study was to evaluate short-term surgical and oncological outcomes after multivisceral pelvic resections in patients with locally advanced rectal cancer.Material and methods. We analyzed surgical outcomes in 32 patients (13 men and 19 women) aged 44-69 years, with locally advanced rectal cancer, who were treated between 2010 and 2016. Of the 32 patients, 28 (87.5 %) had rectal cancer with invasion into adjacent organs (posterior wall of the bladder - 13, uterus - 10, ureters - 5, prostate - 4, vagina - 3; simultaneous damage to more than 2 organs - 14, multiple primary malignant tumors: rectal cancer + bladder cancer - 2, rectal cancer + endometrial cancer - 1, rectal cancer + rectal GIST - 1.Results.Total pelvic evisceration was performed in 6 (18.8 %) cases, combined resection of the rectum and adjacent organs was performed in 26 (81.2 %). Urinary tract resection was performed in 24 (75.0 %) patients. Of these patients, 13 (40.6 %) had primary plasty of the bladder and/or ureters. Postoperative surgical complications were observed in 11 (34.4 %) patients, of whom 7 (21.8 %) patients needed re-surgery. In 1 patient (3.1 %), who died in the early postoperative period, the cause of death was thrombosis of the right iliac vessels with subsequent acute renal failure. For patients with locally advanced rectal cancer, long-term outcomes were as follows: the overall and recurrence-free 2-year survival rates were 75 % and 56.3 %, respectively. All patients with multiple primary malignant tumors were alive with no evidence of disease recurrence at a follow-up of >24 months.Conclusion.Multivisceral resection in patients with locally advanced rectal cancer is a complex surgical procedure requiring the multidisciplinary team of surgeons. Despite high operative morbidity, proper perioperative management of the patients helps to achieve satisfactory immediate treatment outcomes. Long-term outcomes allowed us to consider such resections as a method of choice for locally advanced and multiple primary rectal cancers.
Infections caused by Clostridium difficile in cancer patients
Authors: Klyuchnikova I. A. , Petukhova I. N. , Grigorievskaya Z. V. , Bagirova N. S. , Tereshchenko I. V. , Dmitrieva N. V. 
Published: January 2019

The purpose of the studywas to determine the role of antibiotics as a risk factor of Clostridium difficile-associated diarrhea in hospitalized cancer patients.Material and Methods. The study included 844 hospitalized cancer patients with diarrhea. The presence of Clostridium difficile toxins A and B in the fecal samples was determined by enzyme immunoassay.Results.Clostridium difficile toxins A and B were detected in 100 cancer patients (42 % men and 58 % women). The incidence of Clostridium difficile-associated diarrhea was higher in women than in men (р<0.02). Patients with hemoblastosis and gastrointestinal tumors were more susceptible to the development of Clostridium difficile associated diarrhea (p<0.02). The use of cephalosporin antibiotics was the main risk factor (р<0.001). In our study, 46 % of the patients took antibiotics.Conclusion.Clostridium difficile was shown to play a significant role in the development of diarrhea in cancer patients, and early detection of Clostridium difficile infection contributes to the early onset of therapy.
APPLICATION OF PROTEOMIC TOOLS: THE AUTOLYTIC CHANGES OF PORK MUSCULAR TISSUE
Authors: Chernukha Irina M. , Akhremko Anastasiya G. 
Published: January 2019

Eight protein substances that undergo changes during autolysis were found using the electrophoretic methods with the following mass spectrometric identification. The revealed protein substances have different origin: structural proteins (fragments of troponins T and myosin light chains), and metabolic proteins (creatine kinase, pyruvate kinase and alpha-enolase). The decomposition of the fractions of fast skeletal muscle troponin T in 28.0 kDa, 27 kDa and 26.5 kDa was most pronounced.Identification of constitutive proteins and detection of the products of post — mortem degradation of protein molecules make them suitable candidates for meat quality markers and the following study of these specific fragments will lead to better understanding of the proteolytic activities that take part in the post mortem muscle transformation into meat.
RESEARCH OF AROMA FORMED COMPONENTS OF RENNET CHEESES
Authors: Pochitskaya I M. , Laktionova A. P. , Roslik V. L. 
Published: January 2019

The results of the study of the composition of volatile compounds of rennet cheeses are presented. Sample preparation was performed using Supelco’s solid-phase microextractor, including a special fiber material coated with a layer of divinylbenzene-carboxene-polydimethylsiloxane «DVB / Carboxen / PDMS StableFlesh ™». Using gas chromatography with mass-selective detection, about 400 aroma-forming components were detected, among which 39 compounds were identified, which form the basis of the flavor profile of cheeses. The main flavor descriptors for all cheeses are: propionic, butyric, and caproic acids, acetoin, methyl amyl ketone, 2-nonanone, and limonene. It has been established that the profile of volatile components for cheeses various ripening periods, has significant differences. Thus, for semi-hard cheeses made using propionic acid microorganisms, the most characteristic components are acids — propionic and butyric, as well as compounds of the terpene series o-cymene and β-pinene. For semi-hard cheeses of the Dutch group (formed from the layer), with maturities from 20 days to 3 months, the terpene compounds and esters are the most significant, whereas for superhard cheeses with a maturity of more than a year, the main components affecting the aromatic profile are butyric and caproic acids, 2-heptanone and limonene. Semi-hard and hard cheeses with ripening periods from 3 to 6 months are characterized by a high content of caproic and butyric acids, as well as by the presence of such aromatic substances as limonene and acetic acid ethyl acetate (hexyl acetate). Semi-hard cheeses, which are molded in bulk, with maturities from 10 days to 3 months contain acetoin, caproic acid, as well as significant quantities of the same limonene and hexylacetate.
Febrile seizures: what pediatricians should know
Authors: Belousova E. D. 
Published: January 2019

Febrile seizures are the age-dependent and predictively favorable condition, which is observed in children under 6 years. All febrile seizures are divided into simple (2/3 of all cases), complex and febrile status. Complicated seizuresinclude attacks with focalsymptoms, prolonged and recurring throughout the day. Simple febrile seizures are short, generalized, not repeated. Simple seizures do not harm the child’s neuropsychic development, they do not transform into epilepsy, and do not need chronic prescription of anticonvulsant therapy. A child with normal development and simple febrile seizures does not need an obligatory EEG and MRI of the brain. All the patients of 18 months old or less with the first episode of febrile seizures need to be hospitalized. The risk of recurrence of seizures and their transformation into epilepsy is higher in a child with complex seizures. There is a small group of children with prolonged seizures and / or febrile status, often with neuropsychiatric developmental delay, which needs to be monitored by a neurologist and further examination. Sometimes doctor prescribes long-term anticonvulsant therapy for the children of this group. Febrile seizures can be prevented with special dosage of anticonvulsant drugs quickly reaching a therapeutic concentration in the child’s brain. Febrile seizures are not a contraindication to vaccination and revaccination, attention should be paid in case of DTP vaccination in children with repeated prolonged seizures and / or febrile status.Conflict of interest: The author of this article confirmed the lack of conflict of interest and financial support, which should be reported.