bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge bloats, love builds: Paul on how we are (not) to know things
Authors: Rogan Wil 
Published: November 2024

Abstract
Paul's epistemology was famously mapped onto his eschatology by J. Louis Martyn, but it must be mapped also onto his ecclesiology. For Paul, knowing is bound always and indissolubly to living with others. To understand how Paul would have us know things, then, we must focus not on knowledge as such, but on epistemic practices in ecclesial communities. Whereas the Corinthians’ use of wisdom and knowledge made for fragmentation and dissolution in the body of Christ (1 Cor 1–4; 8–10), Paul would have practices with knowledge instantiate communion and care for one another, as is proper for Christ's body. Integral to theological knowing is a sense of what and whom theology is for, a sense being critically explored in recent evaluations of theological education.
Children, juveniles, and crime in early modern London: Old Bailey trials, 1674–1750
Authors: Capp Bernard 
Published: November 2024

Abstract
This article uses the early records of the Old Bailey to examine how the court handled cases involving children and juveniles, whether as offenders, victims or witnesses. It argues that though juvenile courts belong to a later age, the early modern court was already applying different criteria in trying young offenders. It demonstrates how juries used age, gender and related considerations to justify the ‘pious perjury’ that sheltered many from the full rigour of the law. Previous work on children as victims has focused on child-rape and infanticide. This article explores other categories. It argues that in cases of death following a severe beating the court's sympathies lay firmly with the defendants, determined to uphold the authority of employers and parents. Lastly, the article explores cases involving children as witnesses, which raised difficult questions about the admissibility of evidence. Judges had to decide if the youngster was sufficiently mature to give evidence on oath.
AN INVESTIGATION ON NONLINEAR OPTION PRICING BEHAVIOURS THROUGH A NEW FRÉCHET DERIVATIVE-BASED QUADRATURE APPROACH
Authors: GULEN S. , SARI M. 
Published: November 2024

AbstractComplicated option pricing models attract much attention in financial industries, as they produce relatively better accurate values by taking into account more realistic assumptions such as market liquidity, uncertain volatility and so forth. We propose a new hybrid method to accurately explore the behaviour of the nonlinear pricing model in illiquid markets, which is important in financial risk management. Our method is based on the Newton iteration technique and the Fréchet derivative to linearize the model. The linearized equation is then discretized by a differential quadrature method in space and a quadratic trapezoid rule in time. It is observed through computations that the accurate solutions for the model emerge using very few grid points and time elements, compared with the finite difference method in the literature. Furthermore, this method also helps to avoid consideration of the convergence issues of the Newton approach applied to the nonlinear algebraic system containing many unknowns at each time step if an implicit method is used in time discretization. It is important to note that the Fréchet derivative supports to enhance the convergence order of the proposed iterative scheme.
Comparing Ostrom's design principles to Habraken's open-building framework: disentangling a polycentric built environment
Authors: Horowitz John B. 
Published: November 2024

Abstract
This article compares Habraken's Open-Building framework to Ostrom's design principles. While both frameworks aim to create adaptable and self-governing environments, Ostrom focuses on long-lasting commons governance, while Habraken focuses on designing for change. Unlike Ostrom, Habraken focuses on excludability, implying that private spaces include private and club goods, and public spaces combine public goods and common-pool resources. For Habraken, space is public to people from lower levels who have the right to enter but is private to people from higher levels who can only enter as guests. Habraken also focuses on separating design tasks, such as putting utilities in public spaces accessible from apartment building corridors, to reduce maintenance and repair costs. Utility access from public areas also reduces the need for temporary management and access rights from neighbouring territories, changing many repair and maintenance decisions from collective to private choices. Separating the infill level from the base building gives agents on the lower levels greater ability to adapt and control their own environments. Habraken views the built environment as a self-organizing polycentric system, and an important part of self-organization is appropriately applying themes, patterns, types, and systems. Unlike Ostrom, Habraken doesn't think there are focal action situations.
Highly-efficient (>70%) and Wide-spectral (400–1700 nm) sub-micron-thick InGaAs photodiodes for future high-resolution image sensors
Authors: Geum Dae-Myeong , Lim Jinha , Jang Junho , Ahn Seungyeop , Kim SeongKwang , Shim Joonsup , Kim Bong Ho , Park Juhyuk , Baek Woo Jin , Jeong Jaeyong , Kim SangHyeon 
Published: November 2024

AbstractThis paper demonstrates the novel approach of sub-micron-thick InGaAs broadband photodetectors (PDs) designed for high-resolution imaging from the visible to short-wavelength infrared (SWIR) spectrum. Conventional approaches encounter challenges such as low resolution and crosstalk issues caused by a thick absorption layer (AL). Therefore, we propose a guided-mode resonance (GMR) structure to enhance the quantum efficiency (QE) of the InGaAs PDs in the SWIR region with only sub-micron-thick AL. The TiOx/Au-based GMR structure compensates for the reduced AL thickness, achieving a remarkably high QE (>70%) from 400 to 1700 nm with only a 0.98 μm AL InGaAs PD (defined as 1 μm AL PD). This represents a reduction in thickness by at least 2.5 times compared to previous results while maintaining a high QE. Furthermore, the rapid transit time is highly expected to result in decreased electrical crosstalk. The effectiveness of the GMR structure is evident in its ability to sustain QE even with a reduced AL thickness, simultaneously enhancing the transit time. This breakthrough offers a viable solution for high-resolution and low-noise broadband image sensors.
Whole-exome sequencing reveals novel genomic signatures and potential therapeutic targets during the progression of rectal neuroendocrine neoplasm
Authors: Xu Shi , Zhai Zhi Yong , Zhou Ping , Xue Xiu Fen , Huang Zhao Yu , Li Xia Xi , Yang Gen Hua , Bao Chong Ju , You Li Juan , Cui Xiao Bing , Xia Gui Li , Ou yang Mei Ping , Li Long Fei , Lu Lan , Gong Wei , Pei Xiao Juan , Hu Wei 
Published: November 2024

AbstractRectal neuroendocrine neoplasms (rNENs) are among the most frequent gastrointestinal neuroendocrine neoplasms and pose a serious challenge for clinical management. The size of the primary neoplasm is considered to be the most important predictor of disease progression, but the genetic alterations that occur during the progression of rNENs remain unknown. Here, we performed a comprehensive whole-exome sequencing study on 54 tumor-normal paired, formalin-fixed paraffin-embedded specimens from patients locally diagnosed with rNENs. Of these, 81.5% (n = 44) were classified as small-sized (≤2 cm) rNENs, while the remainder (18.5%, n = 10) were classified as large-sized (>2 cm) rNEN samples. Comparative analysis revealed marked disparities in the mutational landscape between small- and large-sized rNEN samples, and between large-sized rNEN samples with or without lymph node metastases. The high-confidence driver genes RHPN2, MUC16, and MUC4 were significantly mutated in both small- and large-sized rNEN specimens, whereas mutations in MAN2A1, and BAG2 were only identified in large-sized specimens diagnosed with lymph node metastases. Correspondingly, we observed that the mTOR and MAPK pathways were preferentially enriched in the large-sized rNEN specimens. Signature-based analysis revealed that mutational processes associated with defective DNA base excision repair (SBS30) significantly accumulated in large-sized rNEN samples with lymph node metastases, highlighting the important role of this mutagenic process in promoting rNEN progression. We further found that most rNEN subjects, regardless of tumor size, harbored at least one alteration with targeted therapeutic implications. Taken together, these results elucidate the genetic features associated with tumor size and lymphatic metastasis in rNEN patients, which will deepen our understanding of the genetic changes during rNEN progression and potentially directing improvements in rNEN treatment strategies.
Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons
Authors: Handlin Lucas J. , Macchi Natalie L. , Dumaire Nicolas L. A. , Salih Lyuba , Lessie Erin N. , McCommis Kyle S. , Moutal Aubin , Dai Gucan 
Published: November 2024

AbstractCell membranes consist of heterogeneous lipid nanodomains that influence key cellular processes. Using FRET-based fluorescent assays and fluorescence lifetime imaging microscopy (FLIM), we find that the dimension of cholesterol-enriched ordered membrane domains (OMD) varies considerably, depending on specific cell types. Particularly, nociceptor dorsal root ganglion (DRG) neurons exhibit large OMDs. Disruption of OMDs potentiated action potential firing in nociceptor DRG neurons and facilitated the opening of native hyperpolarization-activated cyclic nucleotide-gated (HCN) pacemaker channels. This increased neuronal firing is partially due to an increased open probability and altered gating kinetics of HCN channels. The gating effect on HCN channels is likely due to a direct modulation of their voltage sensors by OMDs. In animal models of neuropathic pain, we observe reduced OMD size and a loss of HCN channel localization within OMDs. Additionally, cholesterol supplementation inhibited HCN channels and reduced neuronal hyperexcitability in pain models. These findings suggest that disturbances in lipid nanodomains play a critical role in regulating HCN channels within nociceptor DRG neurons, influencing pain modulation.
Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases
Authors: Scott Daniel C. , Chittori Sagar , Purser Nicholas , King Moeko T. , Maiwald Samuel A. , Churion Kelly , Nourse Amanda , Lee Chan , Paulo Joao A. , Miller Darcie J. , Elledge Stephen J. , Harper J. Wade , Kleiger Gary , Schulman Brenda A. 
Published: November 2024

AbstractSpecificity of the ubiquitin-proteasome system depends on E3 ligase-substrate interactions. Many such pairings depend on E3 ligases binding to peptide-like sequences - termed N- or C-degrons - at the termini of substrates. However, our knowledge of structural features distinguishing closely related C-degron substrate-E3 pairings is limited. Here, by systematically comparing ubiquitylation activities towards a suite of common model substrates, and defining interactions by biochemistry, crystallography, and cryo-EM, we reveal principles of C-degron recognition across the KLHDCX family of Cullin-RING ligases (CRLs). First, a motif common across these E3 ligases anchors a substrate’s C-terminus. However, distinct locations of this C-terminus anchor motif in different blades of the KLHDC2, KLHDC3, and KLHDC10 β-propellers establishes distinct relative positioning and molecular environments for substrate C-termini. Second, our structural data show KLHDC3 has a pre-formed pocket establishing preference for an Arg or Gln preceding a C-terminal Gly, whereas conformational malleability contributes to KLHDC10’s recognition of varying features adjacent to substrate C-termini. Finally, additional non-consensus interactions, mediated by C-degron binding grooves and/or by distal propeller surfaces and substrate globular domains, can substantially impact substrate binding and ubiquitylatability. Overall, the data reveal combinatorial mechanisms determining specificity and plasticity of substrate recognition by KLDCX-family C-degron E3 ligases.
Mesoscale neuronal granular trial variability in vivo illustrated by nonlinear recurrent network in silico
Authors: Xiao Guihua , Cai Yeyi , Zhang Yuanlong , Xie Jingyu , Wu Lifan , Xie Hao , Wu Jiamin , Dai Qionghai 
Published: November 2024

AbstractLarge-scale neural recording with single-neuron resolution has revealed the functional complexity of the neural systems. However, even under well-designed task conditions, the cortex-wide network exhibits highly dynamic trial variability, posing challenges to the conventional trial-averaged analysis. To study mesoscale trial variability, we conducted a comparative study between fluorescence imaging of layer-2/3 neurons in vivo and network simulation in silico. We imaged up to 40,000 cortical neurons’ triggered responses by deep brain stimulus (DBS). And we build an in silico network to reproduce the biological phenomena we observed in vivo. We proved the existence of ineluctable trial variability and found it influenced by input amplitude and range. Moreover, we demonstrated that a spatially heterogeneous coding community accounts for more reliable inter-trial coding despite single-unit trial variability. A deeper understanding of trial variability from the perspective of a dynamical system may lead to uncovering intellectual abilities such as parallel coding and creativity.
The impact of 9-azaglycophymine and phenylguanidine derivatives on the proliferation of various breast cancer cell lines in vitro and in vivo
Authors: Morgan Ibrahim , Rennert Robert , Berger Robert , Jelača Sanja , Maksimović-Ivanić Danijela , Dunđerović Duško , Mijatović Sanja , Kaluđerović Goran N. , Wessjohann Ludger A. 
Published: November 2024

AbstractQuinazolinones, particularly 9-azaglycophymines, and closely related derivatives and precursors were tested in vitro against various breast cancer cell lines representing the major types of breast tumors. Among the 49 compounds tested, azaglycophymine derivative 19 with an electron-withdrawing substituent demonstrated the most significant anti-proliferative effects, with IC50 values of around 4 µM. Extensive cell-based investigations revealed that compound 19 induced caspase-dependent apoptosis in HCC1937 (human TNBC), BT-474 (human HER2+/HR+), and 4T1 (mouse TNBC) cells. In contrast, in MDA-MB-468 (human TNBC) and MCF-7 (human HR+) cells, the cell death was induced via a non-apoptotic pathway. The in vivo efficacy of compound 19 was validated using a syngeneic orthotopic 4T1 model in BALB/c mice, resulting in significant reduction of 4T1 breast tumor growth upon intraperitoneal (i.p.) application of doses of 5 or 20 mg/kg. These findings highlight the potential of compound 19 as a promising scaffold for the development of new therapeutic agents for various types of breast cancer and a first structure-activity insight.
Anti-industry beliefs and attitudes mediate the effect of culturally tailored anti-smoking messages on quit intentions among sexual minority women
Authors: Zulkiewicz Brittany A , Chen Jarvis T. , Hanby Elaine P. , Ramanadhan Shoba , Obedin-Maliver Juno , Lunn Mitchell R. , Scout N. F. N. , Gordon Bob , Applegate Julia , Machado Ana , Viswanath Kasisomayajula , Potter Jennifer , Liu Sixiao , Tan Andy S. L. 
Published: November 2024

AbstractWe conducted a longitudinal randomized controlled experiment between September 2021 and May 2022 to evaluate whether anti-tobacco industry beliefs and attitudes mediate the effect of culturally tailored anti-smoking messages on quit intentions among US young adult sexual minority women (SMW) ages 18–30 who smoke. Participants were randomized to view up to a total of 20 tailored versus non-tailored messages over one month. Outcomes were assessed at baseline and one-month follow-up. We fit a structural equation model testing the effect of LGBTQ + community-tailored, anti-smoking messages on quit intentions and mediating roles of anti-industry attitudes and beliefs (n = 966). Anti-industry beliefs (indirect effect size = 0.024, 95% confidence interval [CI] = [0.040, 0.056]) and attitudes (indirect effect size = 0.034, 95% CI = [0.006, 0.077]) significantly mediated the effect of the tailored condition on quit intentions. These findings suggest that LGBTQ + -tailored cues in anti-smoking messaging may promote quit intentions indirectly through influencing young adult SMW’s beliefs and attitudes about the tobacco industry. Future campaigns to promote quitting among young adult SMW who smoke should consider incorporating themes to change their beliefs and attitudes about the tobacco industry.Trial registration This study was registered in ClinicalTrials.gov (NCT04812795) on 24/03/2021.
Sirtuin inhibitors reduce intracellular growth of M. tuberculosis in human macrophages via modulation of host cell immunity
Authors: Kalsum Sadaf , Akber Mira , Loreti Marco Giulio , Andersson Blanka , Danielson Eva , Lerm Maria , Brighenti Susanna 
Published: November 2024

AbstractHost-directed therapies aiming to strengthen the body’s immune system, represent an underexplored opportunity to improve treatment of tuberculosis (TB). We have previously shown in Mycobacterium tuberculosis (Mtb)-infection models and clinical trials that treatment with the histone deacetylase (HDAC) inhibitor, phenylbutyrate (PBA), can restore Mtb-induced impairment of antimicrobial responses and improve clinical outcomes in pulmonary TB. In this study, we evaluated the efficacy of different groups of HDAC inhibitors to reduce Mtb growth in human immune cells. A panel of 21 selected HDAC inhibitors with different specificities that are known to modulate infection or inflammation was tested using high-content live-cell imaging and analysis. Monocyte-derived macrophages or bulk peripheral blood cells (PBMCs) were infected with the green fluorescent protein (GFP)-expressing Mtb strains H37Ra or H37Rv and treated with HDAC inhibitors in the micromolar range in parallel with a combination of the first-line antibiotics, rifampicin, and isoniazid. Host cell viability in HDAC inhibitor treated cell cultures was monitored with Cytotox-red. Seven HDAC inhibitors were identified that reduced Mtb growth in macrophages > 45–75% compared to average 40% for PBA. The most effective compounds were inhibitors of the class III HDAC proteins, the sirtuins. While these compounds may exhibit their effects by improving macrophage function, one of the sirtuin inhibitors, tenovin, was also highly effective in extracellular killing of Mtb bacilli. Antimicrobial synergy testing using checkerboard assays revealed additive effects between selected sirtuin inhibitors and subinhibitory concentrations of rifampicin or isoniazid. A customized macrophage RNA array including 23 genes associated with cytokines, chemokines and inflammation, suggested that Mtb-infected macrophages are differentially modulated by the sirtuin inhibitors as compared to PBA. Altogether, these results demonstrated that sirtuin inhibitors may be further explored as promising host-directed compounds to support immune functions and reduce intracellular growth of Mtb in human cells.
The role of antibiotic-derived mycobacterial vesicles in tuberculosis pathogenesis
Authors: Davids C. J. , Umashankar-Rao K. , Kassaliete J. , Ahmadi S. , Happonen L. , Welinder C. , Tullberg C. , Grey C. , Puthia M. , Godaly Gabriela 
Published: November 2024

AbstractPulmonary tuberculosis (TB) causes progressive and irreversible damage to lung tissue, a damage that may not fully resolve after treatment. Mycobacterial vesicles (MVs), which are poorly understood, may contribute to TB pathology. This study investigated the effects of stress, such as treatment with conventional TB antibiotics rifampicin, isoniazid, ethambutol, or treatment with an antimycobacterial peptide (NZX), on mycobacterial vesiculation. Stress from minimal inhibitory concentrations of antibiotics, or peptide all increased MV formation. Electron microscopy and lipid profiling revealed that these vesicles, about 40 nm in size, were released from the bacterial inner membrane and consisted of apolar lipids. Using mass spectrometry, the study identified key differences in MVs protein cargo dependent on the antibiotic used, especially with ethambutol-induced MVs that contained proteins from several mycobacterial pathways. Additionally, toxicology analysis using different concentrations of MVs on primary human macrophages and the monocytic cells indicated that MVs from the different treatments were not toxic to human cells, however induced specific inflammatory profiles. In conclusion, this study identified mycobacterial vesicles to be a potential contributor to tuberculosis pathology.
Distributed network of optically pumped magnetometers for space weather monitoring
Authors: Mrozowski Marcin S. , Bell Angus S. , Griffin Paul F. , Hunter Dominic , Burt David , McGilligan James P. , Riis Erling , Beggan Ciarán D. , Ingleby Stuart J. 
Published: November 2024

AbstractSpatial variation in the intensity of magnetospheric and ionospheric fluctuations during solar storms creates ground-induced currents, of importance in both infrastructure engineering and geophysical science. This activity is presently measured using a network of ground-based magnetometers, typically consisting of extensive installations at established observatory sites. We show that this network can be enhanced by the addition of remote quantum magnetometers which combine high sensitivity with intrinsic calibration. These nodes utilize scalable hardware and run independently of wired communication and power networks. We demonstrate that optically pumped magnetometers, utilizing mass-produced and miniaturized components, offer a single scalable sensor with the sensitivity and stability required for space weather observation. We describe the development and deployment of an off-grid magnetic sensing node, powered by a solar panel, present observed data from periods of low and high geomagnetic activity, and compare it to existing geomagnetic observatories.
The Culture Flex: Advancing Social Justice in Educational Speech-Language Practices
Authors: Scott R. Danielle , Mahowald Megan 
Published: November 2024

Purpose:

Rooted in Black Language, the authors introduce the “culture flex” as a practice of engaging in social justice work. Social justice is necessary to carry out the vision of the American Speech-Language-Hearing Association: effective communication as an accessible, achievable human right for all. The purpose of this tutorial is to define and describe a multifaceted conceptual pathway toward social justice–oriented speech-language practices.

1

The authors acknowledge and interweave their positionalities, their own social justice journeys, and educational speech-language practices experiences to explain the “cultural flex” framework as a pathway for enacting social justice.

Method:
This tutorial will explore existing social justice efforts and conceptual frameworks in the educational institution and current speech-language practices, including cultural responsiveness and cultural humility, and then introduce the concept of cultural flexibility and the implications for educational speech-language practitioners (SLPs). Coined in the education literature, cultural flexibility is defined as a propensity to move across racial–ethnic boundaries.

Conclusions:
There is a need for authentic introspection from practicing SLP justice seekers, who are currently working to uproot inequity and replant justice within the discipline. A human rights–centered social justice orientation is personal, and practical guidance should encompass explicit discussions of positionality and the impact on one's implementation of best practices serving for historically marginalized clients. The authors present the “culture flex” as a mindset shift, a way of viewing practice that centers culture as an invaluable asset, involves ongoing self-reflection, and empowers professionals to move beyond the discomfort of racial/ethnic boundaries to a tendency to enact social justice.