bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstructing small-scale lenses from the cosmic microwave background temperature fluctuations
Authors: Horowitz Benjamin , Ferraro Simone , Sherwin Blake D 
Published: February 2019

AbstractCosmic microwave background (CMB) lensing is a powerful probe of the matter distribution in the Universe. The standard quadratic estimator, which is typically used to measure the lensing signal, is known to be suboptimal for low-noise polarization data from next-generation experiments. In this paper, we explain why the quadratic estimator will also be suboptimal for measuring lensing on very small scales, even for measurements in temperature where this estimator typically performs well. Though maximum likelihood methods could be implemented to improve performance, we explore a much simpler solution, revisiting a previously proposed method to measure lensing that involves a direct inversion of the background gradient. An important application of this simple formalism is the measurement of cluster masses with CMB lensing. We find that directly applying a gradient inversion matched filter to simulated lensed images of the CMB can tighten constraints on cluster masses compared to the quadratic estimator. While the difference is not relevant for existing surveys, for future surveys it can translate to significant improvements in mass calibration for distant clusters, where galaxy lensing calibration is ineffective due to the lack of enough resolved background galaxies. Improvements can be as large as ${\sim } 50{{\ \rm per\ cent}}$ for a cluster at z = 2 and a next-generation CMB experiment with 1 $\mu$K arcmin noise, and over an order of magnitude for lower noise levels. For future surveys, this simple matched filter or gradient inversion method approaches the performance of maximum likelihood methods, at a fraction of the computational cost.
Footprints of the Sagittarius dwarf galaxy in the Gaia data set
Authors: Laporte Chervin F P , Minchev Ivan , Johnston Kathryn V , Gómez Facundo A 
Published: February 2019

ABSTRACT
We analyse an N-body simulation of the interaction of the Milky Way (MW) with a Sagittarius-like dSph (Sgr), looking for signatures which may be attributed to its orbital history in the phase space volume around the Sun in light of Gaia DR2 discoveries. The repeated impacts of Sgr excite coupled vertical and radial oscillations in the disc which qualitatively, and to a large degree quantitatively are able to reproduce many features in the 6D Gaia DR2 samples, from the median VR, Vϕ, V$z$ velocity maps to the local δρ($v$$z$, $z$) phase-space spiral which is a manifestation of the global disc response to coupled oscillations within a given volume. The patterns in the large-scale velocity field are well described by tightly wound spirals and vertical corrugations excited from Sgr’s impacts. We show that the last pericentric passage of Sgr resets the formation of the local present-day δρ($v$$z$, $z$) spiral and situate its formation around 500-800 Myr. As expected δρ(vz, $z$) grows in size and decreases in woundedness as a function of radius in both the Gaia DR2 data and simulations. This is the first N-body model able to explain so many of the features in the data on different scales. We demonstrate how to use the full extent of the Galactic disc to date perturbations dating from Myr to Gyr, probe the underlying potential and constrain the mass-loss history of Sgr. δρ(vz, $z$) looks the same in all stellar populations age bins down to the youngest ages which rules out a bar buckling origin.
Rotational modulation in TESS B stars
Authors: Balona L A , Handler G , Chowdhury S , Ozuyar D , Engelbrecht C A , Mirouh G M , Wade G A , David-Uraz A , Cantiello M 
Published: February 2019

Abstract
Light curves and periodograms of 160 B stars observed by the Transiting Exoplanet Survey Satellite (TESS) space mission and 29 main-sequence B stars from Kepler and K2 were used to classify the variability type. There are 114 main-sequence B stars in the TESS sample, of which 45 are classified as possible rotational variables. This confirms previous findings that a large fraction (about 40 per cent) of A and B stars may exhibit rotational modulation. Gaia DR2 parallaxes were used to estimate luminosities, from which the radii and equatorial rotational velocities can be deduced. It is shown that observed values of the projected rotational velocities are lower than the estimated equatorial velocities for nearly all the stars, as they should be if rotation is the cause of the light variation. We conclude that a large fraction of main-sequence B stars appear to contain surface features which cannot likely be attributed to abundance patches.
Light element discontinuities suggest an early termination of star formation in the globular cluster NGC 6402 (M14)
Authors: Johnson Christian I , Caldwell Nelson , Michael Rich R , Mateo Mario , Bailey John I 
Published: February 2019

ABSTRACT
NGC 6402 is among the most massive globular clusters in the Galaxy, but little is known about its detailed chemical composition. Therefore, we obtained radial velocities and/or chemical abundances of 11 elements for 41 red giant branch stars using high resolution spectra obtained with the Magellan-M2FS instrument. We find NGC 6402 to be only moderately metal-poor with 〈[Fe/H]〉 = −1.13 dex (σ = 0.05 dex) and to have a mean heliocentric radial velocity of −61.1 km s−1 (σ = 8.5 km s−1). In general, NGC 6402 exhibits mean composition properties that are similar to other inner Galaxy clusters, such as [α/Fe] ∼+0.3 dex, [Cr,Ni/Fe] ∼ 0.0 dex, and 〈[La/Eu]〉 = −0.08 dex. Similarly, we find large star-to-star abundance variations for O, Na, Mg, Al, and Si that are indicative of gas that experienced high temperature proton-capture burning. Interestingly, we not only detect three distinct populations but also find large gaps in the [O/Fe], [Na/Fe], and [Al/Fe] distributions that may provide the first direct evidence of delayed formation for intermediate composition stars. A qualitative enrichment model is discussed where clusters form stars through an early ($\lesssim$5–10 Myr) phase, which results in first generation and ‘extreme’ composition stars, and a delayed phase ($\gtrsim$40 Myr), which results in the dilution of processed and pristine gas and the formation of intermediate composition stars. For NGC 6402, the missing intermediate composition stars suggest the delayed phase terminated prematurely, and as a result the cluster may uniquely preserve details of the chemical enrichment process.
Fibroblast-specific plasminogen activator inhibitor-1 depletion ameliorates renal interstitial fibrosis after unilateral ureteral obstruction
Authors: Yao Lan , Wright M Frances , Farmer Brandon C , Peterson Laura S , Khan Amir M , Zhong Jianyong , Gewin Leslie , Hao Chuan-Ming , Yang Hai-Chun , Fogo Agnes B 
Published: February 2019

Abstract

Background
Plasminogen activator inhibitor-1 (PAI-1) expression increases extracellular matrix deposition and contributes to interstitial fibrosis in the kidney after injury. While PAI-1 is ubiquitously expressed in the kidney, we hypothesized that interstitial fibrosis is strongly dependent on fibroblast-specific PAI-1 (fbPAI-1).

Methods
Tenascin C Cre (TNC Cre) and fbPAI-1 knockdown (KD) mice with green fluorescent protein (GFP) expressed within the TNC construct underwent unilateral ureteral obstruction and were sacrificed 10 days later.

Results
GFP+ cells in fbPAI-1 KD mice showed significantly reduced PAI-1 expression. Interstitial fibrosis, measured by Sirius red staining and collagen I western blot, was significantly decreased in fbPAI-1 KD compared with TNC Cre mice. There was no significant difference in transforming growth factor β (TGF-β) expression or its activation between the two groups. However, GFP+ cells from fbPAI-1 KD mice had lower TGF β and connective tissue growth factor (CTGF) expression. The number of fibroblasts was decreased in fbPAI-1 KD compared with TNC Cre mice, correlating with decreased alpha smooth muscle actin (α-SMA) expression and less fibroblast cell proliferation. TNC Cre mice had decreased E-cadherin, a marker of differentiated tubular epithelium, in contrast to preserved expression in fbPAI-1 KD. F4/80-expressing cells, mostly CD11c+/F4/80+ cells, were increased while M1 macrophage markers were decreased in fbPAI-1 KD compared with TNC Cre mice.

Conclusion
These findings indicate that fbPAI-1 depletion ameliorates interstitial fibrosis by decreasing fibroblast proliferation in the renal interstitium, with resulting decreased collagen I. This is linked to decreased M1 macrophages and preserved tubular epithelium.
Wearables for Pediatric Rehabilitation: How to Optimally Design and Use Products to Meet the Needs of Users
Authors: Lobo Michele A , Hall Martha L , Greenspan Ben , Rohloff Peter , Prosser Laura A , Smith Beth A 
Published: February 2019

Abstract
This article will define “wearables” as objects that interface and move with users, spanning clothing through smart devices. A novel design approach merging information from across disciplines and considering users’ broad needs will be presented as the optimal approach for designing wearables that maximize usage. Three categories of wearables applicable to rehabilitation and habilitation will be explored: (1) inclusive clothing (eg, altered fit, fasteners); (2) supportive wearables (eg, orthotics, exoskeletons); and (3) smart wearables (eg, with sensors for tracking activity or controlling external devices). For each category, we will provide examples of existing and emerging wearables and potential applications for assessment and intervention with a focus on pediatric populations. We will discuss how these wearables might change task requirements and assist users for immediate effects and how they might be used with intervention activities to change users’ abilities across time. It is important for rehabilitation clinicians and researchers to be engaged with the design and use of wearables so they can advocate and create better wearables for their clients and determine how to most effectively use wearables to enhance their assessment, intervention, and research practices.
Propofol Anesthesia Increases Long-range Frontoparietal Corticocortical Interaction in the Oculomotor Circuit in Macaque Monkeys
Authors: Ma Li , Liu Wentai , Hudson Andrew E. 
Published: February 2019

Abstract

Editor’s Perspective

What We Already Know about This Topic

What This Article Tells Us That Is New

Background
Frontoparietal functional connectivity decreases with multiple anesthetics using electrophysiology and functional imaging. This decrease has been proposed as a final common functional pathway to produce anesthesia. Two alternative measures of long-range cortical interaction are coherence and phase-amplitude coupling. Although phase-amplitude coupling within frontal cortex changes with propofol administration, the effects of propofol on phase-amplitude coupling between different cortical areas have not previously been reported. Based on phase-amplitude coupling observed within frontal lobe during the anesthetized period, it was hypothesized that between-lead phase-amplitude coupling analysis should decrease between frontal and parietal leads during propofol anesthesia.

Methods
A published monkey electrocorticography data set (N = 2 animals) was used to test for interactions in the cortical oculomotor circuit, which is robustly interconnected in primates, and in the visual system during propofol anesthesia using coherence and interarea phase-amplitude coupling.

Results
Propofol induces coherent slow oscillations in visual and oculomotor networks made up of cortical areas with strong anatomic projections. Frontal eye field within-area phase-amplitude coupling increases with a time course consistent with a bolus response to intravenous propofol (modulation index increase of 12.6-fold). Contrary to the hypothesis, interareal phase-amplitude coupling also increases with propofol, with the largest increase in phase-amplitude coupling in frontal eye field low-frequency phase modulating lateral intraparietal area β-power (27-fold increase) and visual area 2 low-frequency phase altering visual area 1 β-power (19-fold increase).

Conclusions
Propofol anesthesia induces coherent oscillations and increases certain frontoparietal interactions in oculomotor cortices. Frontal eye field and lateral intraparietal area show increased coherence and phase-amplitude coupling. Visual areas 2 and 1, which have similar anatomic projection patterns, show similar increases in phase-amplitude coupling, suggesting higher order feedback increases in influence during propofol anesthesia relative to wakefulness. This suggests that functional connectivity between frontal and parietal areas is not uniformly decreased by anesthetics.
From Biology to Therapy: The CLL Success Story
Authors: Yosifov Deyan Y. , Wolf Christine , Stilgenbauer Stephan , Mertens Daniel 
Published: February 2019

AbstractChemoimmunotherapy has been the standard of care for patients with chronic lymphocytic leukemia (CLL) over the last decade. Advances in monoclonal antibody technology have resulted in the development of newer generations of anti‐CD20 antibodies with improved therapeutic effectiveness. In parallel, our knowledge about the distinctive biological characteristics of CLL has progressively deepened and has revealed the importance of B‐cell receptor (BCR) signaling and upregulated antiapoptotic proteins for survival and expansion of malignant cell clones. This knowledge provided the basis for development of novel targeted agents that revolutionized treatment of CLL. Ibrutinib and idelalisib inhibit the Bruton tyrosine kinase (BTK) and phosphoinositide 3‐kinase (PI3K) delta, respectively, thus interfering with supportive signals coming from the microenvironment via the BCR. These drugs induce egress of CLL cells from secondary lymphoid organs and remarkably improve clinical outcomes, especially for patients with unmutated immunoglobulin heavy‐chain genes or with p53 abnormalities that do not benefit from classical treatment schemes. Latest clinical trial results have established ibrutinib with or without anti‐CD20 antibodies as the preferred first‐line treatment for most CLL patients, which will reduce the use of chemoimmunotherapy in the imminent future. Further advances are achieved with venetoclax, a BH3‐mimetic that specifically inhibits the antiapoptotic B‐cell lymphoma 2 protein and thus causes rapid apoptosis of CLL cells, which translates into deep and prolonged clinical responses including high rates of minimal residual disease negativity. This review summarizes recent advances in the development of targeted CLL therapies, including new combination schemes, novel BTK and PI3K inhibitors, spleen tyrosine kinase inhibitors, immunomodulatory drugs, and cellular immunotherapy.
Modified Selective Neurectomy for the Treatment of Post–Facial Paralysis Synkinesis
Authors: Azizzadeh Babak , Irvine Leslie E. , Diels Jaqueline , Slattery William H. , Massry Guy G. , Larian Babak , Riedler Kiersten L. , Peng Grace Lee 
Published: February 2019

Background:
To address functional and smile dysfunction associated with post–facial paralysis synkinesis, the senior author (B.A.) has offered “modified selective neurectomy” of the lower division of the facial nerve as a long-term solution. This article examines technical considerations and outcomes of this procedure.

Methods:
A retrospective review was conducted of patients who underwent modified selective neurectomy of buccal and cervical branches of the facial nerve performed by a single surgeon over a 4½-year period. House-Brackmann facial grading scores, electronic clinician-graded facial function scale, and onabotulinumtoxinA (botulinum toxin type A) dosages were examined before and after the procedure.

Results:
Sixty-three patients underwent modified selective neurectomy between June 20, 2013, and August 12, 2017. There were no serious complications. The revision rate was 17 percent. Temporary oral incompetence was reported in seven patients (11 percent) postoperatively. A statistically significant improvement was achieved in electronic clinician-graded facial function scale analysis of nasolabial fold depth at rest, oral commissure movement with smile, nasolabial fold orientation with smile, nasolabial depth with smile, depressor labii inferioris lower lip movement, midfacial synkinesis, mentalis synkinesis, platysmal synkinesis, static score, dynamic score, synkinesis score, periocular score, lower face and neck score, and midface and smile score. There was a significant decrease in botulinum toxin type A dosage and House-Brackmann score after surgery.

Conclusion:
Modified selective neurectomy of the buccal and cervical divisions of the facial nerve is an effective long-term treatment for smile dysfunction in patients with post–facial paralysis synkinesis.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.
Early Peritoneal Dialysis Ameliorates Blast Lung Injury by Alleviating Pulmonary Edema and Inflammation
Authors: Chen Kehong , Yang Jie , Xiao Fei , Chen Jia , Hu Wei , Wang Xiaoyue , Wang Liming , Du Juan , Jiang Jianxin , He Yani 
Published: February 2019

ABSTRACT

Background:
Blast lung injury is a high-energy trauma with high mortality for explosion victims. A treatment for blast lung injury is still lacking. The aim of this study was to observe the efficacy and mechanism of peritoneal dialysis combined with glucocorticoids (GC) in the treatment of blast lung injury in rats.

Methods:
Rats were randomly divided into five groups: control, sham, GC, peritoneal dialysis (dialysis for short), and dialysis + GC groups. All rats were injured by a biological shock tube-I.

Results:
The lung water levels in the dialysis group and dialysis + GC group were significantly lower than that in the control group at 6 and 24 h after blast injury. The oxygenation index, forced vital capacity, maximum midexpiratory flow, and functional residual capacity of rats in the dialysis and dialysis + GC groups were significantly higher than those in the control group. The serum levels of interleukin (IL)-1β, IL-6, tumor necrosis factor- α, monocyte chemoattractant protein-1, C-reactive protein, and IL-10 in the dialysis and dialysis + GC groups were significantly lower than those in the control group. Genome-wide mRNA microarray results showed that the aquaporin 1 level in the lung tissue of the dialysis group was 6.67 times higher than that in the control group.

Conclusion:
Early peritoneal dialysis can attenuate pulmonary edema and inflammation, and protect acute lung injury after blast injury.
Left-Sided Ventricular–arterial Coupling and Volume Responsiveness in Septic Shock Patients
Authors: Li Suwei , Wan Xianyao , Laudanski Krzysztof , He Ping , Yang Lihui 
Published: February 2019

ABSTRACT

Background:
Suboptimal ventricular arterial coupling (VAC) is one of the pivotal determinants of inefficient heart performance despite appropriate administration of fluids or vasopressors in shocks. Here, we investigate the performance of VAC in patients who are unresponsive to fluid administration in septic shock.

Methods:
This is a retrospective observational study of septic shock patients (n = 35). VAC was evaluated by effective arterial elastance (EaI), left ventricular end-systolic elastance (EesI), and EaI/EesI. Septic shock patients successfully fluid resuscitated after pulse indicator continuous cardiac output (PiCCO) monitoring, defined as an increase in general end-diastolic ventricular volume (GEDVI) more than 10%, were divided into volume responsive (VVr), and volume unresponsive (VVur) groups based on a cardiac index increase above 10%. We hypothesize that two groups of patients will exhibit dissimilarities of VAC variation, defined as EaI/EesI variation (ΔEaI/EesI).

Results:
Variations of EaI (ΔEaI), and EaI/EesI (ΔEaI/EesI), and systemic vascular resistance index (ΔSVRI) were significantly lower in the VVr group than those in the VVur group (P < 0.05). Variations of cardiac index (ΔCI), stroke volume index (ΔSVI), and EesI (ΔEesI) were significantly higher in patients with ΔEaI/EesI ≤ 0. Concomitantly, ΔEaI and ΔSVRI were significantly diminished as compared with patients with ΔEaI/EesI > 0 (P < 0.05). ΔCI has an inverse relationship with both ΔEaI (r = −0.46, P = 0.006), ΔEaI/EesI (r = −0.65, P < 0.001), and ΔSVRI (r = −0.59, P < 0.001). We observed more patients who were fluid responsive in the ΔEaI/EesI ≤ 0 group than in the group with ΔEaI/EesI > 0 (88.89% vs. 26.92%, P = 0.01).

Conclusions:
Variation of VAC is often related to suboptimal ventricular volume responsiveness among patients with septic shock.
Heparin-Binding Protein as a Prognostic Biomarker of Sepsis and Disease Severity at the Emergency Department
Authors: Kahn Fredrik , Tverring Jonas , Mellhammar Lisa , Wetterberg Nils , Bläckberg Anna , Studahl Erika , Hadorn Niklas , Kahn Robin , Nueesch Susanne , Jent Philipp , Ricklin Meret E. , Boyd John , Christensson Bertil , Sendi Parham , Åkesson Per , Linder Adam 
Published: February 2019

ABSTRACT

Objective:
Rapid and early detection of patients at risk to develop sepsis remains demanding. Heparin-binding protein (HBP) has previously demonstrated good prognostic properties in detecting organ dysfunction among patients with suspected infections. This study aimed to evaluate the plasma levels of HBP as a prognostic biomarker for infection-induced organ dysfunction among patients seeking medical attention at the emergency department.

Design:
Prospective, international multicenter, convenience sample study.

Setting:
Four general emergency departments at academic centers in Sweden, Switzerland, and Canada.

Patients:
All emergency encounters among adults where one of the following criteria were fulfilled: respiratory rate >25 breaths per minute; heart rate >120 beats per minute; altered mental status; systolic blood pressure <100 mm Hg; oxygen saturation <90% without oxygen; oxygen saturation <93% with oxygen; reported oxygen saturation <90%.

Intervention:
None.

Measurements and Main Results:
A total of 524 emergency department patients were prospectively enrolled, of these 236 (45%) were eventually adjudicated to have a noninfectious disease. Three hundred forty-seven patients (66%) had or developed organ dysfunction within 72 h, 54 patients (10%) were admitted to an intensive care unit, and 23 patients (4%) died within 72 h. For the primary outcome, detection of infected-related organ dysfunction within 72 h, the area under the receiver operating curve (AUC) for HBP was 0.73 (95% CI 0.68–0.78) among all patients and 0.82 (95% CI 0.76–0.87) among patients confidently adjudicated to either infection or no infection. Against the secondary outcome, infection leading to admittance to the ICU, death or a persistent high SOFA-score due to an infection (SOFA-score ≥5 at 12–24 h) HBP had an AUC of 0.87 (95% CI 0.79–0.95) among all patients and 0.88 (95% CI 0.77–0.99) among patients confidently adjudicated to either infection or noninfection.

Conclusions:
Among patients at the emergency department, HBP demonstrated good prognostic and discriminatory properties in detecting the most severely ill patients with infection.