bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of clinical risk factors for histological progression of primary biliary cholangitis
Authors: Fujinaga Yukihisa , Namisaki Tadashi , Moriya Kei , Kitade Mitsuteru , Kawaratani Hideto , Shimozato Naotaka , Kaji Kosuke , Takaya Hiroaki , Sawada Yasuhiko , Seki Kenichiro , Akahane Takemi , Okura Yasushi , Sato Shinya , Saikawa Soichiro , Nakanishi Keisuke , Kubo Takuya , Furukawa Masanori , Kitagawa Koh , Ozutsumi Takahiro , Tsuji Yuki , Kaya Daisuke , Mashitani Tsuyoshi , Ishida Koji , Ogawa Hiroyuki , Takagi Hirotetsu , Noguchi Ryuichi , Mitoro Akira , Yamao Junichi , Yoshiji Hitoshi 
Published: April 2019

AimTo identify laboratory predictors of histological progression (HP) of primary biliary cholangitis (PBC).MethodsSequential biopsies were carried out on 35 (11.4%) of 308 patients with PBC treated with ursodeoxycholic acid (UDCA). Patients were divided into high γ‐glutamyl transpeptidase (GGT) (n = 18) and low GGT (n = 17) groups, based on the median value of GGT at baseline. Patients were then categorized as showing HP (progressive group, PG) or lacking HP (non‐progressive group, NPG) according to the Scheuer and Nakanuma classifications, with the latter grading liver fibrosis (fibrosis score) and bile duct loss (BDL score).ResultsAccording to the Scheuer definition, 12 patients had HP and 23 did not. According to the Nakanuma definition, 8 and 27 patients were in the PG and NPG groups, respectively. The fibrosis and BDL scores progressed in 13 and 8 patients, respectively, whereas 22 and 25 patients did not show HP, respectively. Fisher's exact probability test analysis revealed that the rate of HP using the Nakanuma fibrosis score was significantly higher in the high GGT group compared to the low GGT group (P < 0.05). However, no significant correlation was found between the HP of PBC and the biochemical response to UDCA therapy. Both univariate and multivariate logistic regression analyses indicated that the serum GGT level at baseline is an independent risk factor for an increased Nakanuma fibrosis score.ConclusionsThe level of serum GGT at baseline is significantly associated with liver fibrosis progression in PBC, and therefore could help to predict the HP of PBC.
Addition of tumour infiltration depth and extranodal extension improves the prognostic value of the pathological TNM classification for early‐stage oral squamous cell carcinoma
Authors: Boeve Koos , Melchers Lieuwe J , Schuuring Ed , Roodenburg Jan L , Halmos Gyorgy B , van Dijk Boukje A , van der Vegt Bert , Witjes Max J 
Published: April 2019

AimsIn the 8th edition of the American Joint Committee on Cancer TNM staging manual, tumour infiltration depth and extranodal extension are added to the pathological classification for oral squamous cell carcinoma. The currently available 8th TNM validation studies lack patients with conservative neck treatment, and changes in the classification especially affect patients with small tumours. The aim of this study was to determine the potential impact of the changes in the 8th edition pTNM classification on the prognosis and treatment strategy for oral squamous cell carcinoma in a well‐defined series of pT1–T2 patients with long‐term follow‐up.Methods and resultsTwo hundred and eleven first primary pT1–T2 oral squamous cell carcinoma patients, with surgical resection as primary treatment, were analysed retrospectively. One hundred and seventy‐three patients underwent a neck dissection, and 38 patients had frequent clinical neck assessments. Long‐term follow‐up (median 64 months) and reassessed tumour infiltration depth were available. Classification according to the 8th edition criteria resulted in 36% total upstaging with the T classification and 16% total upstaging with the N classification. T3‐restaged patients (n = 30, 14%) had lower 5‐year disease‐specific survival rates than T2‐staged patients (81% versus 67%, P = 0.042). Postoperative (chemo)radiotherapy could have been considered in another seven (3%) patients on the basis of the 8th edition criteria.ConclusionsAddition of tumour infiltration depth and extranodal extension in the 8th TNM classification leads to the identification of oral squamous cell carcinoma patients with a worse prognosis who might benefit from an improved postoperative treatment strategy.
I do not own a car any more: An analysis of possessions’ disposal and changes in consumers’ identities
Authors: Sandes Fabio Shimabukuro , Leandro Julio , Boaventura Patricia , da Silva Junior Adelson Ferreira 
Published: April 2019

AbstractThis research aims to understand the process of cars' disposal, its context, its influences and its impacts on the meanings for consumers and their identities, as well as the new behaviours of these consumers when living without their car(s). We conducted, analysed and interpreted 20 in‐depth interviews with consumers that had previously owned at least one car and had no financial reasons for disposing of their car(s), but had decided to do it, and started to live without them, adopting alternative methods of transportation. Our findings show that these consumers faced a complicated process regarding the disposal of their car(s) but, due to the changes in their circumstances, they re‐signified relevant concepts that were connected to the ownership of a car: Their perception of freedom, comfort, safety and status changed during and after the disposal of their car(s). We also noticed that there were implications in terms of changes in their attitudes and behaviour as both citizens and consumers. As a contribution to the literature, our findings indicate that the re‐signifying of concepts related to possession of the object as well as changes in attitudes and behaviours that consumers undergo in the postdisposal stage, must be included in the model proposed for evaluating consumer behaviour in product disposal.
Early childhood child care and disruptive behavior problems during adolescence: a 17‐year population‐based propensity score study
Authors: Orri Massimiliano , Tremblay Richard E. , Japel Christa , Boivin Michel , Vitaro Frank , Losier Talia , Brendgen Mara R. , Falissard Bruno , Melchior Maria , Côté Sylvana M. 
Published: April 2019

BackgroundChild‐care services during early childhood provide opportunities for social interactions that may facilitate children's learning of acceptable social behaviors. Furthermore, they may reduce exposure to family adversity for some children. The aim of this study was to determine whether intensity of exposure to child‐care services prior to age 5 years has a beneficial effect on disruptive behavior problems during adolescence, and whether the effect is more pronounced for children from low socioeconomic families.MethodsN = 1,588 participants from the Québec Longitudinal Study of Child Development were assessed 14 times from 5 months to 17 years. Intensity of child‐care exposure was measured from 5 months to 5 years of age. Main outcomes were self‐reported physical aggression and opposition from age 12 to 17 years. Family socioeconomic status (SES) was measured at 5 months. Factors explaining differences in child‐care use were controlled using propensity score weights (PSW).ResultsChildren exposed to moderate‐intensity child‐care services (part‐time child‐care services before 1½ years and full time afterward) reported lower levels of physical aggression (d = −.11, p = .056) and opposition (d = −.14, p = .029) during adolescence compared to children exposed to low‐intensity child‐care services. A significant child care by SES interaction (p = .017) for physical aggression indicated that the moderate‐intensity child‐care effect was specific to children from low SES families (d = −.36, p = .002). No interaction with socioeconomic status was found for opposition.ConclusionsModerate‐intensity child‐care services from infancy to school entry may prevent disruptive behavior during adolescence, especially for disadvantaged children.
Investigation of coenzyme Q10 levels and predisposing factors in patients with striae gravidarum
Authors: Yüksel Mavişe , Aktun Hale , Balevi Ali , Çakıcı Çağrı , Ülfer Gözde 
Published: April 2019

AbstractBackgroundStriae gravidarum (SG) can cause pregnant women severe psychological stress.ObjectiveThis study aimed to compare primigravidas with and without SG concerning fasting blood coenzyme Q10 (CoQ10), age, skin type, family history, gestational weight gain, pre‐ and post‐pregnancy BMI, daily water consumption during pregnancy, gender and weight of baby, and the educational level.MethodsThe study included 79 primigravidas in the gestational week of 36 or above. The patients were divided into two groups based on the presence of SG. The fasting blood CoQ10 levels and other associated parameters were compared between the groups.ResultsOf the 79 primigravidas, 35 (44.3%) had SG. There was no statistically significant relationship between striae and CoQ10 (P = 0.144 and P = 0.189, respectively). Predisposing factors for striae were young pregnancy, light skin color, family history, high pre‐ and post‐pregnancy BMI, increased gestational weight gain, and increased newborn weight. There was no significant relationship between striae development and educational level or water consumption during pregnancy.ConclusionThis is the first study to show that CoQ10 did not significantly differ between women with and without SG. Further studies with a larger case series are needed to elucidate predisposing factors for striae and involvement of CoQ10 in this condition.
Zombies and a Decaying American Ontology
Authors: Dawdy Shannon Lee 
Published: April 2019

AbstractWhat would it mean to take zombies seriously? Cultural savants have noted the rise of the zombie in American popular culture in the twenty‐first century. And many scholars have found the zombie useful as a lumbering, empty‐headed metaphor that could signify just about anything. The zombie might look like a loved ovne, but their flesh is rotting and their individualism has tragically withered away. Before I came to zombology, I was already fascinated by an American obsession with preventing the decay of the corpse through an exceptional devotion to embalming. I argue that the intersection of the new zombie‐ism, the rapid decline of embalming, and the mass trauma of 9/11 is significant. Playing with zombies along a spectrum from fright to humor allows Americans to work through not a crisis of meaning, but a crisis of being. The cult of individualism no longer needs a perfect biological body.
Testing the properties of the triarchic model of psychopathy in a community sample: Self‐reported trait aggression and drug consumption associations
Authors: Fernández Dolores , Zabala M. Carmen , Ros Laura , Martínez Manuela , Martínez Alberto , Latorre José Miguel , Ricarte Jorge Javier 
Published: April 2019

The triarchic model of psychopathy encompasses different conceptions of psychopathic personality characterized by three phenotypic components: boldness, disinhibition, and meanness. Psychopathy is a complex construct at both emotional and behavioral level. The aim of this study was to determine the core elements of psychopathic personality in a community sample and analyze the relation between these elements and other personality traits such as aggression, and certain specific behavioral manifestations such as substance use. The study sample comprised 1,159 participants aged between 17 and 74 years, who were administered the Triarchic Psychopathy Questionnaire, the Impulsive‐Premeditated Aggression Scale, and the Aggression Questionnaire. The results show that the constructs of meanness and disinhibition are more highly associated with different forms of both impulsive and premeditated aggression. Furthermore, men scored higher on all three components of the triarchic model compared to women. Finally, higher substance use (tobacco and drugs) was associated with higher scores in meanness, boldness, and disinhibition. These findings demonstrate the importance of assessing psychopathy in a community sample, and the detection of possible risk factors for the disorder.
TDR INTERACTING PROTEIN 3, encoding a PHD‐finger transcription factor, regulates Ubisch bodies and pollen wall formation in rice
Authors: Yang Zhengfu , Sun Lianping , Zhang Peipei , Zhang Yingxin , Yu Ping , Liu Ling , Abbas Adil , Xiang Xiaojiao , Wu Weixun , Zhan Xiaodeng , Cao Liyong , Cheng Shihua 
Published: April 2019

SummaryMale reproductive development involves a complex series of biological events and precise transcriptional regulation is essential for this biological process in flowering plants. Several transcriptional factors have been reported to regulate tapetum and pollen development, however the transcriptional mechanism underlying Ubisch bodies and pollen wall formation remains less understood. Here, we characterized and isolated a male sterility mutant of TDR INTERACTING PROTEIN 3 (TIP3) in rice. The tip3 mutant displayed smaller and pale yellow anthers without mature pollen grains, abnormal Ubisch body morphology, no pollen wall formation, as well as delayed tapetum degeneration. Map‐based cloning demonstrated that TIP3 encodes a conserved PHD‐finger protein and further study confirmed that TIP3 functioned as a transcription factor with transcriptional activation activity. TIP3 is preferentially expressed in the tapetum and microspores during anther development. Moreover, TIP3 can physically interact with TDR, which is a key component of the transcriptional cascade in regulating tapetum development and pollen wall formation. Furthermore, disruption of TIP3 changed the expression of several genes involved in tapetum development and degradation, biosynthesis and transport of lipid monomers of sporopollenin in tip3 mutant. Taken together, our results revealed an unprecedented role for TIP3 in regulating Ubisch bodies and pollen exine formation, and presents a potential tool to manipulate male fertility for hybrid rice breeding.
Alloimmunization in patients with sickle cell disease and underrecognition of accompanying delayed hemolytic transfusion reactions
Authors: Coleman Sarita , Westhoff Connie M. , Friedman David F. , Chou Stella T. 
Published: April 2019

BACKGROUNDPatients with sickle cell disease (SCD) often require red blood cell (RBC) transfusions but alloimmunization remains a significant complication. Alloantibodies can lead to delayed hemolytic transfusion reactions (DHTRs) days to weeks after a RBC transfusion, but may be underrecognized in patients with chronic hemolysis.STUDY DESIGN AND METHODSThis retrospective study aimed to determine the incidence and severity of DHTRs associated with new antibody detection in a cohort of 624 patients with SCD who received transfusion with C‐, E‐, and K‐matched RBCs from primarily African American donors over a 14‐year period. We identified potential DHTRs by the change in hemoglobin (Hb) and %HbS at baseline, before transfusion, and up to 30 days after the transfusion that preceded new antibody identification.RESULTSLaboratory evidence of a DHTR was associated with 54 of 178 evaluable antibodies at first detection (30%), among which less than half were recognized by the patient or provider at the time of the event. A DHTR was associated with 26% of Rh antibodies identified in patients receiving serologic Rh‐matched RBCs, and 38% of non‐Rh antibodies. Twenty‐one of the 54 DHTRs (39%) were associated with a Hb decline greater than 1 g/dL lower than pretransfusion values. Among these 21 severe DHTRs, Rh specificities were identified in 10 of 12 DHTRs in chronically transfused patients, while non‐Rh specificities were associated with seven of nine DHTRs in episodically transfused patients.CONCLUSIONHigh clinical suspicion and monitoring for DHTRs is warranted, as they may be more common in patients with SCD than previously appreciated.
Effectiveness of vibratory stimulation on needle-related procedural pain in children: a systematic review
Authors: Ueki Shingo , Yamagami Yuki , Makimoto Kiyoko 
Published: April 2019

ABSTRACTObjectiveThe objective of this systematic review was to identify, evaluate and synthesize evidence of the effectiveness of vibratory stimulation to reduce needle-related procedural pain in children aged 18 years and younger.IntroductionNeedle-related procedures (NRPs) are common medical procedures associated with pain. Children, in particular, experience unpredictable and severe pain in response to NRPs. The gate control theory is commonly used to countermeasure this pain. Based on this theory, various types of vibratory stimulation have been used to reduce pain in several clinical studies.Inclusion criteriaParticipants were 0- to 18-year-old children who underwent NRPs for any condition. The intervention included any type of vibratory stimulation during the NRPs. The main outcome was pain measured on any pain scale, including both self-rated and observer-rated pain scales. The secondary outcomes were anxiety, the duration of the procedure and the success rate. All studies were randomized controlled trials (RCTs) or quasi-randomized trials published in English.MethodsThe search strategy aimed to identify both published and unpublished studies. A three-step search strategy was utilized in this review. An initial search of MEDLINE and CINAHL was undertaken, followed by a search for unpublished studies. Nine databases were used for the search in October 2017. Papers selected for retrieval were assessed by two independent reviewers for methodological validity prior to inclusion in the review using standardized critical appraisal instruments. Any disagreements that arose between the reviewers were resolved through discussion. Quantitative data were extracted from papers included in the review using a standardized data extraction tool. Where possible, quantitative data were pooled in the statistical meta-analysis. All results were subject to double data entry. Effect sizes were expressed as risk ratios (for categorical data) and weighted mean differences (for continuous data), and their 95% confidence intervals were calculated for analysis.ResultsTwenty-one RCTs involving 1727 children were identified. Blinding of the participants and those delivering the treatment was not achieved in all studies, introducing a potential risk of bias. Overall, the vibratory stimulation was significantly effective in reducing NRP pain in children as shown by measurement of self-rated pain outcomes (standardized mean difference [SMD]: –0.55, 95% confidence interval [CI]: –0.92 to –0.18) and observer-rated pain outcomes (SMD: –0.47, 95% CI: –0.76 to –0.18). Among secondary outcomes, the effect on the child's anxiety (SMD: –1.03, 95% CI: –1.85 to –0.20) was significant.ConclusionsVibratory stimulation was effective in reducing NRP pain in children; however, blinding was not possible in the trials. Moreover, heterogeneity was high. Therefore, the confidence in the evidence is low. Personal preference should be a priority when using vibratory stimulation in the clinical setting.
Provenance of detrital sediments in Santa Barbara Basin, California, USA: Changes in source contributions between the Last Glacial Maximum and Holocene
Authors: Napier Tiffany J. , Hendy Ingrid L. , Fahnestock M. Florencia , Bryce Julia G. 
Published: April 2019

AbstractDetrital terrestrial sediments preserved in near-shore marine basins bear distinctive geochemical identifiers that can be used to identify the on-shore sediment sources and sediment routing through time. Santa Barbara Basin (SBB), offshore of southern California, USA, contains a well-known, continuous, high-resolution Holocene flood record that can provide insights into the frequency and changes in on-shore sources across time for such events. Here SBB-adjacent stream bed sediments are characterized using mineralogical, elemental, and radiogenic strontium and neodymium isotopic compositions. Modern and Holocene SBB flood deposits and Last Glacial Maximum (LGM) sediments were similarly analyzed. The Southern Slopes of the Santa Ynez Mountains and Topatopa Mountains account for ∼85% of SBB Holocene flood deposit sediments, as calculated from Sr-Nd isotope mixing models. During the LGM sea level low stand, the Southern Slopes contribution increased (to ≥90%), while relative sediment contribution from Santa Clara River diminished. This loss was likely compensated, however, by increased sediment flux from the Southern Slopes and the Channel Islands.
Development and pilot of a multicriteria decision analysis (MCDA) tool for health services administrators
Authors: Blythe Robin , Naidoo Shamesh , Abbott Cameron , Bryant Geoffrey , Dines Amanda , Graves Nicholas 
Published: April 2019

IntroductionHealth administration is complex and serves many masters. Value, quality, infrastructure and reimbursement are just a sample of the competing interests influencing executive decision-making. This creates a need for decision processes that are rational and holistic.MethodsWe created a multicriteria decision analysis tool to evaluate six fields of healthcare provision: return on investment, capacity, outcomes, safety, training and risk. The tool was designed for prospective use, at the beginning of each funding round for competing projects. Administrators were asked to rank their criteria in order of preference. Each field was assigned a representative weight determined from the rankings. Project data were then entered into the tool for each of the six fields. The score for each field was scaled as a proportion of the highest scoring project, then weighted by preference. We then plotted findings on a cost-effectiveness plane. The project was piloted and developed over successive uses by the hospital’s executive board.ResultsTwelve projects competing for funding at the Royal Brisbane and Women’s Hospital were scored by the tool. It created a priority ranking for each initiative based on the weights assigned to each field by the executive board. Projects were plotted on a cost-effectiveness plane with score as the x-axis and cost of implementation as the y-axis. Projects to the bottom right were considered dominant over projects above and to the left, indicating that they provided greater benefit at a lower cost. Projects below the x-axis were cost-saving and recommended provided they did not harm patients. All remaining projects above the x-axis were then recommended in order of lowest to highest cost-per-point scored.ConclusionThis tool provides a transparent, objective method of decision analysis using accessible software. It would serve health services delivery organisations that seek to achieve value in healthcare.