bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic kidney disease in children: problems of arterial hypertension
Authors: Karimdzhanov I. A. , Iskanova G. K. , Israilova N. A. 
Published: August 2019

The review contains materials on the course of chronic kidney disease (CKD) in children with arterial hypertension (AH). The relationship between CKD and AH was shown, where hastening of CKD progression to end-stage renal failure in the presence of AH was established. The regulation of AH in children is necessary for the treatment of CKD, because AH is not established on time, is not well controlled and is often masked. Impaired vascular regulation, fluid overload, increased cardiac output, and peripheral vascular resistance, alone or in combination, can lead to hypertension in CKD. The use of modern methods for monitoring and controlling blood pressure is crucial to improve the management of AH and prevent damage to target organs in children. 24-hour blood pressure measurements are an important tool in determining the prognosis and treatment of children with CKD. To identify impaired renal function in CKD, a large number of biomarkers are used. Glomerular filtration rate (GFR), serum creatinine and cystatin C are currently used as biomarkers for renal failure. Recently, biomarkers, including KIM-1, LFABP, NGAL, and IL-18 have been proposed as markers of acute kidney injury, and they may be useful in the future for early detection of CKD progression in children. In newborns and children of early and older age, hypertension occurs due to renovascular and parenchymal diseases.AH is considered a marker of CKD severity and is a risk factor for progressive deterioration of kidney function, as well as thedevelopment of cardiovascular diseases. Sympathetic hyperactivity, excessive formation of free radicals, reduced bioavailability of nitric oxide (NO) and excessive production of angiotensin II leads to an increase in blood pressure. Obesity or an increase in body mass index (BMI) is currently considered as a risk factor not only for cardiovascular diseases and diabetes but also for CKD. Hyperuricemia and CKD are closely related, as the accumulation of uric acid is associated with hypertension, metabolic syndrome and microalbuminuria, which are also risk factors for the progression of CKD. AH has a detrimental effect on target organs, including the kidneys, eyes, and heart. Lifestyle modifications, weight control, healthy eating, reduced sodium intake, maintenance exercises and basic drug therapy using angiotensin-converting enzyme inhibitors (ACE inhibitors), angiotensin receptor blockers can slow the progression of CKD in children.
Influence of prednisone therapy on physical development of children with nephrotic syndrome
Authors: Nastausheva T. L. , Boeva E. E. , Zvyagina T. G. , Kulakova E. N. , Nastausheva N. S. , Volosovets G. G. 
Published: August 2019

THE AIM: to compare the parameters of physical development (PD) in children with idiopathic nephrotic syndrome (INS), depending on the treatment with prednisone.PATIENTS AND METHODS. The effect of treatment with prednisone on PD was analyzed in 60 children with INS aged from 2 to 17 years. The children were divided into 2 groups: 30 children who did not receive prednisone, and 30 children who received it during the last 6 months before the study (1st and 2nd group, respectively). The groups compared the anamnestic parameters and the risk factors of children in terms of length, weight, and body mass index.RESULTS. When comparing the characteristics of the risk factors of children of the above 2 groups, differences in body mass and BMI were established. In children who received prednisone for the last 6 months, body weight and BMI were significantly exceeded compared to WHO standards and similar patients who did not receive prednisone for the last 6 months. We have established a reliable association of the Z-BMI criterion with the cumulative dose of prednisone in the last 6 months: r = 0.49, p <0.05. At the same time, no reliable association of body weight with a cumulative dose of prednisone, which the child received before 6 months, has been identified. When analyzing the effectiveness of different doses of prednisone therapy for stopping relapses in children with steroid-sensitive INS, it was found that the onset and duration of remission did not significantly differ when taking standard (60mg/m2/day or 2 mg/kg/day) and half as much (1mg/kg/day) doses of prednisone.CONCLUSION. The relationship of the body mass of children with INS and the cumulative dose of prednisone in the last 6 months has been established. When treating a recurrent steroid-sensitive non-relapsing INS, a decrease in the daily dose of prednisone from 2 mg/kg/day to 1 mg/kg/day is possible in adolescents who are afraid of steroid obesity or who have had severe complications during previous courses of prednisone therapy.
Pengaruh Suku Bunga, Nilai Tukar Rupiah, Inflasi Dan Harga Minyak Dunia Terhadap Ihsg Di Bei
Authors: Sumitra Reagan Wijaya 
Published: August 2019

This research is to analyze the influence of macroeconomic towards composite share price index in Indonesia. This research is an explanatory research with quantitative paradigm. This research is using secondary data and the sample determined by full sampling technique based on time series date that has been accessed on official website of Bank Indonesia and finance yahoo year 2013 to 2017 which is consist of 60 samples. This research used multiple linier regression analysis. Based on classic assumption test, the datas in this research has been comply the assumption. Based on the multiple linier regression test, exchange rates and crude oil price has positive effect, whereas the inflation and interest rates has negative effect on composite share price index. Based on R2 test, 73,3 % of composite share price index influenced by interest rates, exchange rates, inflation and crude oil price. Based on F test, macro economic factors simultantly influence composite share price index. Based on t test, interest rates and exchange rates has a significant effect on composite share price index, whereas the inflation and crude oil price did not have significant effect on composite share price index.
Faktor-Faktor Yang Memengaruhi Sustainable Entrepreneurship Pada Usaha Kecil Menengah Di Jakarta
Authors: Kianto Michael 
Published: August 2019

Entrepreneurship has both positive and negative contributions to our society. On the negative side, the degradation of environmental quality caused by entrepreneurial activities requires serious attention. As such, sustainable entrepreneurship has been suggested as an attempt to alleviate environmental problems. Furthermore, there are scant studies in regard to motivation and propensity in the development of sustainable entrepreneurs among SMEs practitioners. Thus, this study was conducted to address the factors associated with propensity for sustainable entrepreneurship among owners-managers of SMEs. This sample collection through purposive sampling. There are 100 respondents as sample of this research by using simple random sampling method. The data collection method conducted by questionnaire. Based on the descriptive analyses, this paper found that owners-managers of SMEs generally possessed positive or favorable attitude towards sustainability, concerned about social pressures on sustainability, perceived that sustainable entrepreneurship was attractive and perceived themselves as having sufficient ability for sustainable entrepreneurship..
Decomposition of social problems of management digitalization
Authors: Raychenko A. V. 
Published: August 2019

The decomposition of social problems of management digitalization has been proved, presented and investigated in the article, the directories and formats of their positioning have been selected and opened consistently. Key objects of the research are manifestations of influence of social problems on setting, development and implementation of programs of management digitalization, approaches, opportunities and examples of definition of options of their resolution. Conducted analysis and formulated conclusions allow us to create complete representation and to implement applied recommendations about selection, a research and solution influence of social problems on management digitalization of modern organization. This is especially relevant today, when national, sectoral and regional programs for the digitalization of the economy and management define one of the key trends in breakthrough socio-economic development.The examples of the manifestation, study and resolution of social problems of digitalization from the actual practice of managing leading, efficiently operating domestic enterprises in the real sector of their sectors have been analyzed. The presenting material has been collected, processed and adapted by the author in the process of development, implementation and maintenance of the use of organizational and methodological materials commissioned by these organizations, as part of the implementation of applied research. In the statement of the provisions of the article, the material has been also used, collected by the author on open resources and in the processes of interaction with organizations of the infrastructure, that are actively introducing and widely using digital products and databases in management practice. Carried-out analysis of specific material actually involved in the processes of enterprises and organizations allows us reliably, adequately and prospectively oriented to identify, evaluate and decompose the existing range of social problems of management digitalization.
Changing of the characteristics of the labor potential in the transition to the technogenic society
Authors: Tettsoeva O. A. 
Published: August 2019

The issues of changing the characteristics of labor potential in the transition to the technogenic society in the postindustrial community, which the processes of further urbanization and development of mega-cities are typical for, – have been examined. The technogenic society has been considered as the community, the basis of which is characterized by reducing dependence of a person on social groups, amplification of personality in creative work, changing of motivation pattern, high pace of social changes, alteration of interpersonal communication models. The movement of quantitative characteristics of labor potential is due to decreasing birth rates, the increasing share of older age groups, the downward changing of migration scale. Trends in the qualitative characteristics are pre-determined by the possibility of continuous learning and self-education. This in turn leads to changing of the situation in the labor market, where low-skilled workers are becoming non-competitive. High qualification fundamentally change an employee’s motivation: the significance of material incentives decreases, external motivation changes for the internal one, the meaningfulness of work, the independence of work performance, the responsibility for decisions taken, become an issue of the highest priority.The transition to the new culture of the technogenic society requires alteration of both professional and personal communications. The communication environment moves increasingly into the virtual world. However, a need is noted to lay emphasis upon the risks of the technogenic society, that relate to the increased scale of a person’s presence in the virtual world and to manage such risks. The risks of the technogenic society are connected with a person’s dependence on cyberspace, which has a negative impact on his or her mental health, and permanent using of electronic devices pre-determines risks of deteriorating his or her physical health. The digital transformation of the society requires the special attention to the safety of presence in cyberspace not only from the point of view of anonymizing of the personalized content, that identifies a particular person, but also taking into account the geolocation of his or her physical presence in the geographical coordinates of the real space. With the virtualization of all aspects of a person’s life, there are the increased risks of changing attitude towards the family values, forming the fundamental basis of the society’s functioning. The technogenic society contributes the risk of conscious single life, rejection family values. This risks will be catastrophic for the existence of humanity.
MEDYADA ALGI YÖNETİMİ ARACILIĞIYLA KAMUOYU OLUŞTURULMASI: 1915 AVUSTURALYASINDA BROKEN HILL OLAYI ÜZERİNDEN SAVAŞ SÖYLEMİ ÇÖZÜMLEMESİ
Authors: ÇAĞLAK Engin 
Published: August 2019

İletişim ya da yayın organları aracılığı ile
aktarılan bilgi, bir mesaj olarak birey ve toplumlar arası iletişiminde
olaylardan haberdar olma konusunda önemli bir rol oynamaktadır. Öte yandan
haber olarak bilgi her zaman doğru aktarılmamaktadır. Bilginin kasıtlı olarak yanlış, eksik veya
tahrip edilerek aktarılması bir dezenformasyon sürecidir ve bu süreç medyada
özellikle savaş ve barış söyleminde toplumsal algı yönetiminin önemli bir
parçasını oluşturmaktadır. Bu çalışmada, I. Dünya Savaşının önemli bir cephesi
konumundaki Çanakkale-Gelibolu savaşı öncesi yaşanılan ve aynı zaman da
çalışmanın örneklemini de oluşturan “ Broken Hill” olayına "Barrier
Miner" gazetesi üzerinden savaş söylemi çözümlemesi yoluyla ışık tutulması
amaçlanmıştır. Çalışmada içerik analizi yöntemiyle savaş söyleminde metinsel,
dilsel ve görsel ögeler irdelenmiştir. Araştırmanın sonucunda dezenformasyon
yöntemiyle savaş söyleminin kamuoyu oluşturmada ve algı yönetiminde eski veya
yeni medya mecralarında ne kadar etkili olduğu 1915 Avustralya'sı basınından
bir örnekle irdelenmiş ve bu örnek olayın acı sonuçlarının günümüz medyası ve
okurlarına medyaya bakışı açısından arz ettiği önem tartışılmıştır.
Desvelando a presença do enfoque Ciência, Tecnologia e Sociedade (CTS) no curso superior de Gastronomia da Universidade Cruzeiro do Sul
Authors: Toledo Rosana Fernandez Medina , Maciel Maria Delourdes 
Published: August 2019

Nesta pesquisa investigou-se a presença de elementos do enfoque CTS (Ciência, Tecnologia e Sociedade) na Matriz Curricular do Curso Superior de Tecnologia em Gastronomia da Universidade Cruzeiro do Sul. O objetivo foi desvelar os elementos científicos, sociológicos, tecnológicos, éticos e estéticos presentes na Matriz Curricular do Curso de Gastronomia da Universidade Cruzeiro do Sul e verificar se esses elementos contemplam o enfoque CTS na Formação de um Gastrônomo. Para tanto utilizou-se como referência a abordagem da Ciência, Tecnologia e Sociedade (CTS) que tem como premissa a alfabetização científica e tecnológica do estudante como forma de subsidiar a participação democrática do mesmo na sua atuação profissional e na tomada de decisões, de forma crítica e reflexiva. Os resultados da pesquisa apontaram a presença do enfoque CTS nas diversas disciplinas que permeiam a formação do gastrônomo. A metodologia de pesquisa utilizada foi a da abordagem Qualitativa do tipo Análise Documental. A partir da análise das ementas detectou-se a terminologia representativa do enfoque CTS que se apresentam e se repetem nas ementas analisadas numa perspectiva da defesa de uma educação científica e social no Curso Superior de Gastronomia. Levando-se em conta o conjunto de ementas analisadas, foi possível identificar diferentes compreensões e ideias acerca do conceito de cidadania. Concluímos que a abordagem CTS está presente nas disciplinas do curso e contribuem para a formação científica, tecnológica e social dos estudantes. A partir dos resultados desta tese elaborou-se uma Matriz de Referência para o Curso de Gastronomia, com enfoque nas competências CTS inseridas nos documentos do MEC para o ENADE da Gastronomia no ano de 2015.
National point prevalence survey on healthcare-associated infections in acute care hospitals, Switzerland, 2017
Authors: Zingg Walter , Metsini Aliki , Balmelli Carlo , Neofytos Dionysios , Behnke Michael , Gardiol Céline , Widmer Andreas , Pittet Didier ,   on behalf of the Swissnoso Network
Published: August 2019

Background
As a part of the national strategy on the prevention of healthcare-associated infections (HAI), a point prevalence survey (PPS) was conducted in acute care hospitals in Switzerland.

Aim
Our objective was to assess the burden of HAI in Swiss acute care hospitals.

Methods
All acute care hospitals were invited to participate in this cross-sectional survey during the second quarter of 2017. The protocol by the European Centre for Disease Prevention and Control was applied. Patients of all ages, hospitalised on the day of survey were included, except when admitted to outpatient clinics, emergency and psychiatry.

Results
Ninety-six acute care hospitals (79% of all hospitals ≥ 100 beds) provided data on 12,931 patients. Pooled and randomised HAI prevalences were 5.9% (95% confidence interval (CI): 5.5–6.3) and 5.4% (95% CI: 4.8–6.0), respectively. The HAI incidence was estimated at 4.5 (95% CI: 4.0–5.0). The most common type of HAI was surgical site infection (29.0%), followed by lower respiratory tract (18.2%), urinary tract (14.9%) and bloodstream (12.8%) infections. The highest prevalence was identified in intensive care (20.6%), in large hospitals > 650 beds (7.8%), among elderly patients (7.4%), male patients (7.2%) and patients with an ultimately (9.3%) or rapidly (10.6%) fatal McCabe score.

Discussion
This is the first national PPS of Switzerland allowing direct comparison with other European countries. The HAI prevalence was at European Union average (5.9% in 2016 and 2017), but higher than in some countries neighbouring Switzerland. Based on the limited information from previous surveys, HAI appear not to decrease.
Molecular and epidemiological characteristics of human Puumala and Dobrava-Belgrade hantavirus infections, Germany, 2001 to 2017
Authors: Faber Mirko , Krüger Detlev H , Auste Brita , Stark Klaus , Hofmann Jörg , Weiss Sabrina 
Published: August 2019

Introduction
Two hantavirus species, Puumala (PUUV) and Dobrava-Belgrade (DOBV) virus (genotype Kurkino), are endemic in Germany. Recent PUUV outbreaks raised questions concerning increasing frequency of outbreaks and expansion of PUUV endemic areas.

Aims
To describe the epidemiology of human PUUV and DOBV infections in Germany.

Methods
We conducted an observational retrospective study analysing national hantavirus surveillance data notified to the national public health institute and hantavirus nucleotide sequences from patients collected at the national consultation laboratory between 2001 and 2017. Matching molecular sequences with surveillance data, we conducted epidemiological, phylogenetic and phylogeographic analyses.

Results
In total, 12,148 cases of symptomatic hantavirus infection were notified 2001–17 (mean annual incidence: 0.87/100,000; range: 0.09–3.51). PUUV infections showed a highly variable space-time disease incidence pattern, causing large outbreaks every 2–3 years with peaks in early summer and up to 3,000 annually reported cases. Sex-specific differences in disease presentation were observed. Of 202 PUUV nucleotide sequences obtained from cases, 189 (93.6%) fall into well-supported phylogenetic clusters corresponding to different endemic areas in Germany. DOBV infections caused few, mostly sporadic cases in autumn and winter in the north and east of Germany.

Conclusions
The frequency of PUUV outbreaks increased between 2001 and 2017 but our data does not support the suggested expansion of endemic areas. The epidemiology of PUUV and DOBV-Kurkino infections differs in several aspects. Moreover, the latter are relatively rare and combining efforts and data of several countries to identify risk factors and develop specific recommendations for prevention could be worthwhile.
METODE EKSTRAKSI DNA TANAMAN TANPA PRESIPITASI ETANOL UNTUK KEGIATAN <em>POLYMERASE CHAIN REACTION (PCR)</em>
Authors: Nugroho Kristianto , Terryana Rerenstradika Tizar , Reflinur . , Lestari Puji 
Published: August 2019

A Simplified Plant DNA Extraction Protocol without Ethanol Precipitation for Polymerase Chain Reaction (PCR) Activities ABSTRACTMolecular-based research in agriculture includes DNA extraction stage involving DNA precipitation using ethanol or isopropanol which tends to take a long time. The purpose of this study was to obtain a plant DNA extraction method for Polymerase Chain Reaction (PCR) activities without going through the ethanol precipitation stage. Five important agricultural commodity crops, namely rice, corn, soybeans, chilies, and shallots were extracted by DNA using the modified Doyle and Doyle method. After the extraction phase using chloroform and isoamil alcohol solvents, the supernatant obtained was not precipitated using ethanol but was directly diluted and used as a template in PCR activities using two pairs of Simple Sequence Repeat (SSR) markers. The results showed that all samples could be well amplified, and amplicon tape visualized in both 1% agarose gel and 6% polyacrylamide gel were clearly visible. This method could save time and material, and reduce the dependence on liquid nitrogen. But this method is still limited to PCR requirements only, and cannot be used for activities that require high quality and quantity of DNA such as Next Generation Sequencing (NGS), digestion, and hybridization.Keywords: DNA extraction, ethanol precipitation, liquid nitrogen, PCR, SSR, ABSTRAKPenelitian berbasis molekuler pada bidang pertanian mencakup tahapan ekstraksi DNA yang melibatkan presipitasi DNA menggunakan etanol atau isopropanol yang cenderung memakan waktu lama. Tujuan penelitian ini adalah untuk memperoleh metode ekstraksi DNA tanaman untuk kegiatan Polymerase Chain Reaction (PCR) tanpa melalui tahapan presipitasi etanol. Lima tanaman komoditas pertanian penting yaitu padi, jagung, kedelai, cabai, dan bawang merah diekstraksi DNA-nya menggunakan metode Doyle and Doyle yang dimodifikasi. Setelah tahap ekstraksi menggunakan pelarut kloroform dan isoamil alkohol, supernatan yang terbentuk tidak dipresipistasi menggunakan etanol melainkan langsung diencerkan dan digunakan sebagai template dalam kegiatan PCR menggunakan dua pasang marka Simple Sequence Repeat (SSR). Hasil menunjukkan bahwa seluruh sampel dapat teramplifikasi dengan baik serta pita hasil amplikon yang tervisualisasi baik pada gel agarosa 1% maupun gel poliakrilamid 6% terlihat jelas. Metode ini dapat menghemat waktu dan bahan serta mengurangi ketergantungan pemakaian nitrogen cair. Tetapi metode ini masih terbatas hanya untuk kebutuhan PCR saja dan tidak dapat digunakan untuk kegiatan yang membutuhkan DNA dengan kualitas serta kuantitas tinggi seperti Next Generation Sequencing (NGS), digesti, maupun hibridisasi.Kata Kunci: ekstraksi DNA, nitrogen cair, PCR, presipitasi etanol, SSR