bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial properties of thioridazine
Authors: Hrynchuk N. , Vrynchanu N. 
Published: September 2019

The emergence and spread of antibiotic-resistant strains of microorganisms reduces the effectiveness of antibiotic therapy and requires finding solutions to problems, one of which is the study of antimicrobial properties in drugs of various pharmacological groups.
The purpose of the work was to summarize the data on the antibacterial activity of thioridazine and its derivatives to determine the feasibility and prospects of creating new antibacterial drugs on their basis.
The paper presents literature data on the effects of thioridazine on the causative agent of tuberculosis, antistaphylococcal activity, susceptibility of plasmodium and trypanosoma.
The antibacterial activity of the drug was established within in vitro studies with the determination of MIC towards gram-positive and gram-negative microorganisms, ex vivo using macrophage lines, as well as within in vivo experiments on mice.
It is established that the neuroleptic thioridazine is characterized by pronounced anti-tuberculosis activity, the mechanism of action is associated with the impact on the cell membrane of M. tuberculosis, inactivation by calmodulin and inhibition of specific NADH-dehydrogenase type II.
The literature data indicate that thioridazine is able to increase the activity of isoniazid against the strains of mycobacteria that are susceptible and resistant to its action. It has been established that resistance to thioridazine in antibiotic-resistant M. tuberculosis strains is not formed.
The drug is characterized by its ability to inhibit the growth and reproduction of both methicylin-sensitive (MSSA) and methicilin-resistant (MRSA) strains of Staphylococcus aureus, which has been proven within in vitro experiments.
The effectiveness of thioridazine has been proven within in vivo experiments in case of skin infection and sepsis caused by S. aureus. Antimicrobial effect of the drug is also observed towards to plasmodium (P. falciparum) and trypanosomes (Trypanosoma spp.).
Currently, the synthesis of thioridazine derivatives is carried out to identify compounds with a pronounced antibacterial effect. Some of the first synthesized compounds are not inferior or superior to thioridazine by the inhibitory effect.
Thus, these data suggest that drugs of different pharmacological groups, including drugs that affect the nervous system - thioridazine and its derivatives, can be a source of replenishment of the arsenal of antimicrobial drugs to control such threatening infections as tuberculosis and diseases caused by polyresistant strains of microorganisms.
Synthesis, physical-chemical and biological properties of 8-R-thioderivatives of 1-benzyltheobromine
Authors: Ivanchenko D. G. , Romanenko M. I. , Samura B. A. , Kornienko V. I. 
Published: September 2019

Key way for creating new medicinal drugs is structural modification of known and existent natural compounds with high biological activity. In this aspect researchers’ attention is drawn by xanthine derivatives which appear to be antagonists of adenosine receptors, phosphodiesterase inhibitors and histone deacetylase inducers. This resulted in their widespread application in medicine to cure asthma, bronchitis and chronic obstructive pulmonary disease. In addition, xanthine derivatives are used as diuretics, analgesics, heart pacemakers, anti-inflammatory, psychotropic and renal protective agents.
The aim of this work lies in developing unique methods to synthesize undocumented in other scientific papers 8-thioderivatives of 1-benzylthiobromine and also studying of their physical, chemical and biological properties.
Acute toxicity of synthesized compounds has been studied with the application of Kerber method. The study of diuretic activity of obtained compounds was carried out applying Berkhin method. Analgesic activity of synthesized xanthines was studied at ‘acetic acid writhing’ model. Anti-inflammatory activity was studied at ‘acute aseptic edema’ model. Antioxidant activity was studied in vitro using the method of non-enzymatic initiation of free-radical oxidation.
Heating of 1-benzyl-8-bromotheobromine with double excess of sodium sulphidenonahydrate in dimethylformamide environment results in formation of 8-thiotheobromine. Reactions of thioxanthines with halogenketones and chloroacetamide proceed smoothly with their short-time heating in aqueous alcohol environment.
By applying such computer programs as ALOGPS, DRAGON, GUSAR and ACD/Percepta Platform was established viability of further invitro and invivo research.
Accessible laboratory methods have been elaborated to synthesize 8-thiosubstituted 1-n-methylbenzyltheobromine, their structure having been proved by elemental analysis, PMR-spectroscopy and mass-spectrometry data.
Molecular and pharmacological descriptors to forecast properties of the obtained substances have been calculated, in addition to acute toxicity index.
Also the study of acute toxicity, diuretic, analgesic, anti-inflammatory and anti-oxidant activity of synthesized compounds has been carried out.
After additional research 1-benzyl-8-(2-oxo-2-phenylethylthio)theobromine can be used in medical practice as an antioxidant agent.
Peran Sicantik dalam Meningkatkan Kinerja Perawat di Rumah Sakit
Authors: Swedarma Eka , Dwidasmara Dwidasmara 
Published: September 2019

The low ability of nurses in documenting nursing care as a result of limited human resources, too much writing format, differences in perceptions between nurses and the inability of nurses to enforce nursing diagnoses accurately will have an impact on the performance and service delivery to patients. This study aimed to fine out the nurse’s performance based on the characteristics of respondents and determine the effect of the application of the Si-Cantik application program (Electronic nursing record system) on the performance of nurses at the hospital. The research method used a one group pre-post test design approach with an intervention in the installation of an electronic nursing record system that is computer-based in the treatment room. The sampling technique used Simple random sampling with sample of 35 nurses. Statistical analysis using Chi-square test and Wilcoxon signed rank test. The results showed that the majority of respondents (77.14%) found it easy to apply the program, most nurses (77.68%) had good performance and statistically the implementation of the electronic nursing record system had an effect on nurses' performance in providing nursing care in hospitals (p = 0.004). The application of electronic nursing records system can be applied by nurses as supporting nurses' performance in providing nursing care in hospitals and becoming a reference in the use of digital nursing as an effort to develop self-potential so that they can carry out nursing services professionally.
Keyakinan sebagai Faktor Penting dalam Kepatuhan Pengobatan TB pada Anak
Authors: Trianingsih Devi , Wanda Dessie , Waluyanti Fajar Tri 
Published: September 2019

Children are one of the most vulnerable populations to the spread of tuberculosis (TB) ger, however, unfortunately the success of TB treatment in DKI Jakarta is still quite low. This study aimed to determine the factors that most influence TB child treatment adherence. The method used was descriptive analysis with cross sectional approach. The sample was determined using techniques Consecutive Sampling: Non Probability Sampling which numbered 168 people. This study illustrated that belief variable was the most influencing factors of TB treatment adherence in children (p value 0,001; α=0.05; OR 8,02 after controlled by long-term treatment of TB, PMO, cognitive developments stages, coping behaviour, memory, treatment regimens, communication with health care providers, social support and access to health facilities. This study expected to be source of knowledge for nurses to provide client’s belief and improve adherence to TB treatment in children.
Emerging threat in antifungal resistance on superficial dermatophyte infection
Authors: Sultana Razia , Wahiduzzaman Md 
Published: September 2019

Background: Dermatophytosis are most common fungul infection globally and according to WHO the prevalence is about 20-25% and does not spare people of any race or age. Over the past few years antifungal resistance has been emerged due to irrational use of antifungal drugs in cutaneous mycosis.
Objective: The aim of the study is to evaluate the efficacy of different antifungul drugs (Terbinafin. Fluconazole, Itraconazole, Griseofulvin) on superficial mycosis depending on various factors.
Methods: This prospective study was conducted among the Superficial fungul infected patients from April' 2017 to October 2017 in Khulna Medical College Hospital (KMCH) and dermatologist's private chamber in Khulna city. All the enrolled patients were put on oral Terbinafin, Fluconazole, Itraconazole and Griseofulvin. Each patient was given single antifungal drug orally. These cases were thus followed up after two months of treatment to look for persistent infection, cure or any relapse clinically.
Result: Among 194 patient 89 were given Tab. Terbinafin (250mg) where resistance cases were 20.22%. More cases (33.96%) were resistant to Cap. Fluconazol (50mg). High percentage of cases were resistant to Cap. Itraconazole (76.47%). Griseofulvin resistant cases were observed in 25.71%. Drug response is very poor (69%) in patient who had been suffering from diabetes mellitus.
Conclusion: Appropriate antifungal drugs should be chosen with strict indication, dose, duration, selection of perfect local preparation and taking laboratory facilities where necessary.
Bang Med J (Khulna) 2018; 51 : 21-24
Causative agents for diarrhoea in under 5 children in a tertiary care hospital
Authors: Pervin Mst Khashruba , Jhora Sanya Tahmina , Paul Shikha , Naher Akhtarun , Sarkar Dipika 
Published: September 2019

Background: nfectious diarrhoea is a major public health problem in developing countries like Bangladesh. Bacteria and parasites are important etiological agents for diarrhoea in infants and children.
Objectives: To isolate and identify the causative organisms of diarrhoea from diarrhoeal stools in under 5 children.
Methodology: This was an observational cross sectional study carried out at Microbiology Department of Sir Salimullah Medical College, Dhaka. A total of 217 diarrhoeal patients upto 5 years age, attending Pediatric unit of Sir Salimullah Medical College and Mitford Hospital, Dhaka and Dhaka Shishu Hospital, Dhaka during the period of July 2015 to June 2016, were enrolled in the study. For isolation of enteric bacteria, diarrhoeal stools were inoculated on Mackonkey agar media and for Campylobacter spp. diarrhoeal stools were inoculated on selective Modified Campy-BAP media and nonselective Blood agar media with membrane filter. Positive culture was confirmed by Gram stain morphology and standard biochemical tests. Oocysts of Cryptosporidium were identified by Modified Ziehl Neelsen staining and other parasites were identified by wet mount preparation.
Results: Out of 217 diarrhoeal stools bacteria were isolated from 97 (44.7%) patients. Among 97 cases, Escherichia coli were detected in 51(52.58%) patients; Campylobacter spp. were detected in 23(23.71%) patients; Shigella spp. were detected in 15(15.46%) patients and Salmonella spp. were detected in 8(8.25%) patients. Microscopic finding of diarrhoeal stools were detected by pus cells with or without RBCs in 90(70.31%) samples. Cysts of Giardia intestinalis were found in 9(4.14%) samples, cysts of Entamoeba histolytica in 2(0.9%) samples, eggs of Trituris trichiura in 2(0.9%) samples and oocysts of Cryptosporidium were found in.5(2.30%) samples.
Conclusion: Escherichia coli was the most common bacteria and Giardia intestinalis was predominant parasite causing diarrhoea in under 5 children.
Bang Med J (Khulna) 2018; 51 : 25-28
Hemşirelerin Psikososyal Sorunlarının ve Stresle Başa Çıkma Tarzlarının İncelenmesi
Authors: Nehir Sevgi , Güngör Nazmiye 
Published: September 2019

Amaç: Bu
çalışma hemşirelerin psikososyal sorunlarının ve
stresle başa çıkma tarzlarının belirlenmesi amacıyla yapıldı.

Gereç ve Yöntem: Tanımlayıcı tipte planlanan çalışma, Nisan 2018 – Haziran
2018 tarihleri arasında Menemen Devlet Hastanesinde yürütüldü. Çalışmanın
örneklemini bu hastanede görev yapan toplam 184 hemşire oluşturdu.
Verilerin toplanmasında, Kişisel Bilgi formu,
Hastane Anksiyete Depresyon Ölçeği (HAD) ve Stresle Başa Çıkma Tarzları Ölçeği
kullanılmıştır. Verilerin analizinde sayı yüzde, Mann Whitney U, Kruskal
Wallis testi ve Spearman korelasyon analizi yöntemlerine başvuruldu.

Bulgular: Araştırma da hemşirelerin %94’ ünün kadın, %52.7’ sinin
39 yaş ve 39 yaş üstü, %62.5’inin lisans ve lisans üstü, %82.6’sının mesleğini
severek yaptığı belirlendi. Hemşirelerin yaş grupları eğitim
durumları, hastalığa sahip olma durumu, mesleği severek yapma, çalıştıkları
birimden memnun olma durumları, psikososyal desteğe ihtiyaç duyma durumları ile
stresle başa çıkma tarzı arasında istatistiksel olarak anlamlı fark olduğu
belirlendi (p&lt;0,05).

Sonuç:
Hemşirelerin
psikososyal sorunlarında artış olması stresle baş etme alt boyutlarında; kendine güvenli yaklaşım, iyimser yaklaşım ve
sosyal destek arama yaklaşımı alt boyut puanlarında azalma olduğu, kendine
güvensiz yaklaşım ve boyun eğici yaklaşım alt boyut puanlarında ise artış olduğu
belirlendi.
Presentación
Authors: Jabonero Mariano 
Published: September 2019

En este año 2019 la OEI celebra su 70 aniversario. En nuestro ánimo no está utilizar esta efeméride para echar la vista atrás y recrearnos en los aciertos y éxitos del pasado, por muchos que éstos sean. Por el contrario, estamos trabajando para posar una mirada más lúcida que nunca en la realidad cambiante de nuestra región y en el futuro incierto que nos espera. Porque sólo así conseguiremos que la OEI sea relevante en la región y, sobre todo, siga siendo útil para nuestros países.
La RIE, que durante más de un cuarto de siglo ha sido punto de encuentro de reconocidos expertos iberoamericanos, está llamada a jugar un papel muy destacado en esta nueva etapa de madurez de la OEI. Porque queremos, más que nunca, que nuestra Organización se vuelque en la producción y difusión de nuevo conocimiento; de soluciones y propuestas innovadoras con las que construir sólidas políticas públicas y encontrar respuesta a los retos que se nos plantean.
A Rare Case of Unilateral Retinitis Pigmentosa
Authors: Nusanti Syntia , Sidik Mohamad , Djatikusumo Ari , Aditya Elyas 
Published: September 2019

Introduction: Retinitis pigmentosa (RP) is a hereditary disorder that diffusely involve photoreceptor and retinal pigment epithelial (RPE). It is characterized by progressive visual field loss and abnormal ERG. Unilateral RP is a rare condition that is usually sporadic. Clinical presentation and ancillary test results are similar to bilateral RP, with only one eye affected. In making the diagnosis of unilateral RP, clinicians must be able to rule out secondary causes, document a normal ERG in the unaffected eye, and follow-up the patient for at least 5 years to rule out bilateral but asymmetric disease. the aim of this case report is how to diagnose a rare case unilateral RP from clinical examination and ancillary tests.
Methods: We report a case of a 33-year-old female with slowly progressive restriction of visual field of the left eye in the last one year before admission. Ophthalmological examination of the left eye revealed bone spicules spreading to peripheral fundus. Visual field examination revealed severely constricted visual field of the left eye. The multifocal electroretinogram (mfERG) examination showed severely depressed ERG function with reduced foveal responses. The fellow eye was within normal limit.
Results: Patient was diagnosed with unilateral RP and must be followed-up for at least five years to rule out bilateral yet asymmetric disease. Making diagnosis of unilateral RP become one of the challenging case. Clinicians must be able to rule out the secondary causes that also have unilateral pigmentary retinal degeneration.
Conclusion: With a good clinical examination and some simple ancillary tests, we could correctly diagnose unilateral RP. However, in this case we still need five years follow up to rule out bilateral RP yet asymmetric disease.
Surgical Technique of Late Spontaneous IOL-Capsular Bag Complex Dislocation with Low Corneal Endothelial Cell Density: A Case Report
Authors: Wardhana Firman Setya , Sakti Dhimas Hari , Supanji Supanji , Sasongko Muhammad Bayu , Widayanti Tri Wahyu , Agni Angela Nurini 
Published: September 2019

Introduction: IOL-capsular bag complex dislocation is a rare but serious complication of phacoemulsification surgery. Technique to repair this complication should be based on various clinical parameters including quality of corneal endothelial cells and the type of dislocated IOL.
Case Presentation: We present a case of a 67-year-old male with left eye spontaneous one-piece foldable IOL-capsular bag complex dislocation to vitreous cavity 4 years after phacoemulsification surgery. Visual acuity of the left eye was 1/60, pupil was round with 3 mm diameter and IOP was 15 mmHg. Noncontact specular microscopy examination showed that the corneal endothelial cell density was 1100 cells/mm2. It was managed with 23-gauge posterior vitrectomy, IOL evacuation to anterior chamber, releasing the capsular bag and repositioning the IOL into posterior chamber by sutured scleral fixation.
Result: Follow-up at 6thmonth, best corrected visual acuity of the left eye achieved 6/6, IOL at central position and the last corneal endothelial cell density was 1076 cells/mm2.
Conclusions: Late spontaneous IOL-capsular bag complex dislocation with low corneal endothelial cell density can be safely managed with proper surgical technique. Vitrectomy and sutured scleral fixation of the previously dislocated IOL were effective in managing such case. Longer follow-up should be done to assure the stability of IOL position and the quality of corneal endothelial cells.
LEVELS OF HYPOXIA INDUCIBLE FACTOR-1α (HIF-1α) AND INTERCELLULAR ADHESION MOLECULE-1 (ICAM-1) AFTER INTRAVITREAL BEVACIZUMAB IN PROLIFERATIVE DIABETIC RETINOPATHY
Authors: Yuneta Ressa , Gondhowiardjo Tjahjono Darminto , Dharma Rahayuningsih , Jusman Sri Widia A. , Prihartono Joedo , Victor Andi Arus 
Published: September 2019

Purpose: to assess the levels of Hypoxia-inducible factor-1α (HIF-1α) and intercellular adhesion molecule-1 (ICAM-1) in vitreous of proliferative diabetic retinopathy patients which were given intravitreal bevacizumab (IVB), as well as its relation to the central macular thickness (CMT) measured prior to vitrectomy.
Methods: thirty-two eyes were randomized into two groups, one that received an IVB injection at 1-2 weeks previtrectomy and the control group which did not receive any injection. Measurement of HIF-1α and ICAM-1 was conducted using enzyme-linked immunosorbent assay (ELISA). The CMT were measured at the initial visit, prior to vitrectomy, and at follow up time (2, 4, and 12 weeks postoperatively) using Stratus OCT.
Results: The mean levels of HIF-1α vitreous (ng/mg protein) in the control group and IVB respectively 0.020 (0.006; 0.077) and 0.029 (0.016; 0.21). Vitreous levels of ICAM-1 (ng /mL) in control group and IVB group were 20.10 (3.41; 40.16) and 23.33 (0.63; 68.5). The mean levels of HIF-1α and ICAM-1 vitreous obtained did not differ significantly between the two groups.
Conclusion: The levels of HIF-1α and ICAM-1 in PDR patients do not decrease after one injection of intravitreal Bevacizumab 1-2 weeks prior to vitrectomy. The concentration of vitreous HIF-1α and ICAM-1 are not directly related to the CMT.
Pelatihan Manajemen Keuangan sebagai Upaya Peningkatan Daya Saing UMKM dalam Menghadapi MEA di Kecamatan Tomoni Kabupaten Luwu Timur
Authors: Junaidi Junaidi 
Published: September 2019

Tujuan program PKM ini adalah Memberikan pengetahuan dan keterampilan mengenai Manajemen Keuangan kepada para pelaku UMKM di kota Palopo. Target khusus yaitu Memberikan pengetahuan dan keterampilan kepada UMKM dalam pengembangan usaha melalui pelatihan, bimbingan dalam meningkatkan Manajemen Keuangan. Adapun Prospek pengembangan UMKM dikaji berdasarkan pada analisa keuangan. Rencana kegiatan program PKM ini adalah Melakukan sosialisasi kepada pelaku UMKM, Penyiapan peralatan pelatihan yang menunjang keberhasilan PKM, Melakukan bimbingan terhadap pelaku UMKM dalam menyusun laporan keuangannya, Melakukan pelatihan dalam meningkatkan pengetahuan dan keterampilan baik melalui workshop maupun kegiatan-kegiatan lain, Monitoring dan evaluasi kegiatan untuk menunjang keberhasilan dan keberlanjutan usaha
Sistem Pelatihan Citaro “Cilok Tabaro” Di Kabupaten Luwu Dan Kota Palopo
Authors: Wahida Altri , Sari Harmita 
Published: September 2019

Makanan khas berasal dari Sulawesi Selatan, yang tepatnya berada di daerah Luwu dan Palopo adalah kapurung. Cita rasa tradisional ini terbuat dari bahan dasar tabaro yang salah satu komoditas yang relatif tidak dipengaruhi oleh musim yang terus berganti. Oleh karena itu, untuk meningkatkan tingkat konsumsi tabaro diperlukan pelatihan untuk membuat sesuatu yang bernilai ekonomi dan mempopulerkan makanan khas Luwu. Kegiatan dalam pelatihan ini menggunakan pendekatan persuasif edukatif yaitu melalui metode diskusi, dan praktek. Hasil dari pelatihan dapat disimpulkan bahwa masyarakat di Kabupaten Luwu dan Kota Palopo memberikan respon positif, memiliki keterampilan, kamampuan dan kemauan yang sangat tinggi dan terlihat menyenangkan ketika memberikan pelatihan. Kendala yang ditemukan tidak memiliki dorongan dari orang terdekat untuk mengembang usaha cilok tabaro. Oleh karena itu, diperlukan kegiatan pelatihan secara berkala dan berkelanjutan.
O HOMEM CANSADO
Authors: Rosostolato Breno 
Published: September 2019

É inegável a importância dos movimentos emancipatórios e de autonomia dos sujeitos. Proporcionando debates, reflexões e estabelecendo espaços de diálogo para fertilizar temas emergentes e considerados tabus. São sistemas essencialistas, falas que ecoam violências, culturas de abusos e negação dedireitos, estes movimentos identitários legitimam aqueles que sofrem por causa de políticas silenciadoras e invisibilidade. Esse é o cenário propício para refletirmos sobre as masculinidades que estabelecem segregações dessas identidades, pautadas em privilégios e generificações de corpos, desejos e subjetividades, mas também, enquanto políticas de poder. Olhar para as masculinidades é olhar para as masculinidades tóxicas e as relações de dominação. Masculinidades alexitímicas. Constatar que não são imóveis e intocáveis, mas revelam pluralidades e estão em plena transformação. Eis o homem angustiado e cansado que, marcado pelo totalitarismo patriarcal, não mais o sustenta e que, uma vez se reconhecendo neste contexto de exploração, arbitrariedades e violências, não admite mais estas condições. É diante de rupturas de fronteiras, entre o patriarcalismo colonial, masculinidades emancipatórias e interseccionalidades com as feminilidades que localizamos novas perspectivas de ser-homem e a crítica a uma masculinidade sem hegemonias,compreendendo que outras identidades e protagonismos devem ser respeitados.
SEXUALIDADE NA LONGEVIDADE E SUA SIGNIFICAÇÃO EM QUALIDADE DE VIDA
Authors: Oliveira Francisco Fabrício Firmino de , Vieira Kay Francis Leal 
Published: September 2019

O artigo consiste numa revisão da literatura sobre a sexualidade na longevidade e sua contribuição para a qualidade de vida da pessoa idosa. Inicialmente, trazemos um breve resumo sobre sexualidade na longevidade com seus aspectos positivos que perpassam gerações trazendo qualidade de vida, saúdee bem estar e resignificando a vida dos idosos. Discorremos sobre mitos e verdades no quesito sexualidade na vida dos longevos. Por fim, destacamos as motivações dos idosos para a manutenção de uma vida sexual ativa com suas inovações e adaptações, considerando que apesar do envelhecimento trazer modificações na vida sexual da pessoa idosa é importante ressaltar que as vivências sexuais se mostra essencial para que se envelheça com uma boa qualidade de vida.