bluuebunny/crossref_metadata_2025_split huggingface dataset:
BMI and Labor Market Participation: A Cohort Study of Transitions Between Work, Unemployment, and Sickness Absence
Authors: Bramming Maja , Jørgensen Maja B. , Christensen Anne I. , Lau Cathrine J. , Egan Kia K. , Tolstrup Janne S. 
Published: September 2019

ObjectiveThis study aimed to test the hypotheses that individuals with obesity are at higher risk of unemployment and sickness absence and have a lower chance of getting employed compared with individuals with normal weight.MethodsData on weight and height were collected at baseline from 87,796 participants in the Danish National Health Survey 2010. Participants were then followed in national registers for 5 years. Outcome measures were transitions from employment to unemployment and sickness absence and the transitions from unemployment or sickness absence to employment. Data were analyzed by Cox proportional hazards models adjusted for potential confounders.ResultsHazard ratios for unemployment were 1.18 (95% CI: 1.10‐1.26) for individuals with obesity and 1.27 (95% CI: 1.14‐1.41) for individuals with severe obesity compared with individuals with normal weight. Participants with obesity also had a higher risk of sickness absence. Additionally, participants with obesity who were unemployed at baseline had a lower chance of becoming employed compared with participants with normal weight.ConclusionsObesity was associated with a higher risk of unemployment and sickness absence compared with individuals with normal weight. Additionally, obesity was associated with a lower chance of employment.
Comparisons of Self‐Reported and Measured Height and Weight, BMI, and Obesity Prevalence from National Surveys: 1999‐2016
Authors: Flegal Katherine M. , Ogden Cynthia L. , Fryar Cheryl , Afful Joseph , Klein Richard , Huang David T. 
Published: September 2019

ObjectiveThe aim of this study was to compare national estimates of self‐reported and measured height and weight, BMI, and obesity prevalence among adults from US surveys.MethodsSelf‐reported height and weight data came from the National Health and Nutrition Examination Survey (NHANES), the National Health Interview Survey, and the Behavioral Risk Factor Surveillance System for the years 1999 to 2016. Measured height and weight data were available from NHANES. BMI was calculated from height and weight; obesity was defined as BMI ≥ 30.ResultsIn all three surveys, mean self‐reported height was higher than mean measured height in NHANES for both men and women. Mean BMI from self‐reported data was lower than mean BMI from measured data across all surveys. For women, mean self‐reported weight, BMI, and obesity prevalence in the National Health Interview Survey and Behavioral Risk Factor Surveillance System were lower than self‐report in NHANES. The distribution of BMI was narrower for self‐reported than for measured data, leading to lower estimates of obesity prevalence.ConclusionsSelf‐reported height, weight, BMI, and obesity prevalence were not identical across the three surveys, particularly for women. Patterns of misreporting of height and weight and their effects on BMI and obesity prevalence are complex.
Pulmonary giant chondromatous hamartoma with multifocal evolution in an infant
Authors: Bailly Charlotte , Verschuur Arnauld , Bosdure Emmanuelle , Dabadie Alexia , Petit Philippe , Maues de Paula Andre , Coulomb‐L'hermine Aurore , Longy Michel , André Nicolas 
Published: September 2019

AbstractHamartoma is the most common benign pulmonary tumor in adults, but is rarely described in the pediatric population. Giant chondromatous and progressive forms are even rarer. We report the novel case of a 13‐month‐old infant hospitalized for giant pulmonary chondromatous hamartoma discovered during a septic episode, rapidly progressive, with severe multifocal lesions, without clear response to several cytotoxic therapies. No predisposition syndrome was identified.
Successful treatment with daratumumab for post‐HSCT refractory hemolytic anemia
Authors: Even‐Or Ehud , Naser Eddin Adeeb , Shadur Bella , Dinur Schejter Yael , Najajreh Mohammad , Zelig Orly , Zaidman Irina , Stepensky Polina 
Published: September 2019

AbstractAutoimmune cytopenias (AIC) following allogeneic hematopoietic stem cell transplantation (HSCT) may cause significant morbidity and mortality and are often challenging to treat. We present a case of a pediatric patient with primary myelofibrosis of infancy caused by VPS45 protein deficiency, who developed severe refractory hemolytic anemia and immune‐mediated thrombocytopenia 3.5 months following HSCT. After the failure of several treatments, he received daratumumab, an anti‐CD38 specific antibody, and demonstrated fast and sustained response. The only side effect was delayed recovery of humoral immunity. Daratumumab, by targeting antibody‐producing plasma cells, may be a valid treatment option for refractory post‐HSCT AIC.
An instrument in search of a theory: Structural validity of the Kaufman assessment battery for children‐second edition normative update at school‐age
Authors: McGill Ryan J. 
Published: September 2019

AbstractThe present study examined the factor structure of the Kaufman assessment battery for children‐second edition normative update with normative sample participants aged 7–18 years (N = 500) using confirmatory factor analysis with maximum likelihood estimation and multidimensional scaling procedures. For the 10 subtest Cattell‐Horn‐Carroll core battery configuration, an alternative hierarchical model with four group‐specific factors (crystallized ability, perceptual reasoning, short‐term memory, and long‐term storage and retrieval) provided the best fit to the normative data for both age groups. These results suggest caution for interpreting the visual processing and fluid reasoning index scores in isolation given the inability to locate those constructs independently at school‐age. Implications for the clinical interpretation of the measurement instrument moving forward are discussed.
2′‐5′‐Isomerically Linked Thrombin‐Binding Aptamer (isoTBA) Forms a Stable Unimolecular Parallel G‐Quadruplex in the Presence of Sr2+ Ions
Authors: Wagh Atish A. , Fernandes Moneesha 
Published: September 2019

AbstractThe ability of the isomeri 2′‐5′‐phosphodiester‐linked thrombin‐binding DNA aptamer pentadecamer G2T2G2TGTG2T2G2 (isoTBA), to fold into G‐quadruplex structures in the presence of different mono‐ and divalent cations is reported. Strikingly, Sr2+ ions cause isoTBA to fold into a stable parallel unimolecular G‐quadruplex, in contrast to the antiparallel unimolecular G‐quadruplex fold observed in the presence of K+. IsoTBA being advantageously more stable than TBA to nuclease degradation, may thus be useful in the selective detection of Sr2+ ions, which it can sense with a detection limit of ∼ 55 μM.
Investigation of the Influence of Process Conditions on the Catalytic Performance of Co–Ce/SiO2 Catalyst for CO Hydrogenation Reaction using RSM Method
Authors: Arsalanfar Maryam , Nouri Azita , Abdouss Majid 
Published: September 2019

AbstractThe Co−Ce/SiO2 catalyst was prepared using fusion method and evaluated in the fixed bed micro‐reactor for light olefins production. The influence of various operational conditions of reaction temperature (300‐450 °C), H2/CO feed ratio (1‐4) and total reaction pressure (1‐10 bar) was investigated on the (C2‐C4) light olefins production using statistical method. The modeling and optimization processes were performed using response surface methodology (RSM) method. A polynomial equation for each response was successfully fitted to the experimental data. The optimization results show that the best operational conditions for light olefins production are as follows: T=365 °C, P=5 bar and H2/CO=2. Under these optimized conditions the selectivity of (C2‐C4) light olefins and CO conversion% are maximum and the methane selectivity is minimum concurrently. Catalyst characterization was performed using, XRD, BET, TGA, DSC, TPR and SEM.
Anisotropic Growth and Scanning Tunneling Microscopy Identification of Ultrathin Even‐Layered PdSe2 Ribbons
Authors: Jiang Shaolong , Xie Chunyu , Gu Yue , Zhang Qinghua , Wu Xianxin , Sun Yilin , Li Wei , Shi Yuping , Zhao Liyun , Pan Shuangyuan , Yang Pengfei , Huan Yahuan , Xie Dan , Zhang Qing , Liu Xinfeng , Zou Xiaolong , Gu Lin , Zhang Yanfeng 
Published: September 2019

AbstractPalladium diselenide (PdSe2) is an emerging 2D layered material with anisotropic optical/electrical properties, extra‐high carrier mobility, excellent air stability, etc. So far, ultrathin PdSe2 is mainly achieved via mechanical exfoliation from its bulk counterpart, and the direct synthesis is still challenging. Herein, the synthesis of ultrathin 2D PdSe2 on conductive Au foil substrates via a facile chemical vapor deposition route is reported. Intriguingly, an anisotropic growth behavior is detected from the evolution of ribboned flakes with large length/width ratios, which is well explained from the orthorhombic symmetry of PdSe2. A unique even‐layered growth mode from 2 to 20 layers is also confirmed by the perfect combination of onsite scanning tunneling microscopy characterizations, through deliberately scratching the flake edge to expose both even and odd layers. This even‐layered, ribboned 2D material is expected to serve as a perfect platform for exploring unique physical properties, and for developing high‐performance electronic and optoelectronic devices.
The Next Generation of Colloidal Probes: A Universal Approach for Soft and Ultra‐Small Particles
Authors: Mark Andreas , Helfricht Nicolas , Rauh Astrid , Karg Matthias , Papastavrou Georg 
Published: September 2019

AbstractThe colloidal probe technique, which is based on the atomic force microscope, revolutionizes direct force measurements in many fields, such as interface science or biomechanics. It allows for the first time to determine interaction forces on the single particle or cell level. However, for many applications, important “blind spots” remain, namely, the possibility to probe interaction potentials for nanoparticles or complex colloids with a soft outer shell. Definitely, these are colloidal systems that are currently of major industrial importance and interest from theory. The here‐presented novel approach allows for overcome the aforementioned limitations. Its applicability has been demonstrated for 300 nm sized carboxylate‐modified latex particles as well as sub‐micron core–shell particles with a soft poly‐N‐isopropylacrylamide hydrogel shell and a rigid silica core. For the latter, which until now cannot be studied by the colloidal probe technique, determined is the temperature dependency of electrosteric and adhesion forces has been determined on the single particle level.
Microfluidic Single‐Cell Omics Analysis
Authors: Xu Xing , Wang Junxia , Wu Lingling , Guo Jingjing , Song Yanling , Tian Tian , Wang Wei , Zhu Zhi , Yang Chaoyong 
Published: September 2019

AbstractThe commonly existing cellular heterogeneity plays a critical role in biological processes such as embryonic development, cell differentiation, and disease progress. Single‐cell omics‐based heterogeneous studies have great significance for identifying different cell populations, discovering new cell types, revealing informative cell features, and uncovering significant interrelationships between cells. Recently, microfluidics has evolved to be a powerful technology for single‐cell omics analysis due to its merits of throughput, sensitivity, and accuracy. Herein, the recent advances of microfluidic single‐cell omics analysis, including different microfluidic platform designs, lysis strategies, and omics analysis techniques, are reviewed. Representative applications of microfluidic single‐cell omics analysis in complex biological studies are then summarized. Finally, a few perspectives on the future challenges and development trends of microfluidic‐assisted single‐cell omics analysis are discussed.
Production, engine performance, combustion, emission characteristics and economic feasibility of biodiesel from waste cooking oil: A review
Authors: Rekhate Chhaya , Prajapati Abhinesh Kumar 
Published: September 2019

AbstractThe depletion of fossil fuel reserves and increasing demands for diesel are considered to be important triggers for many of the initiatives that have been taken to search for possible sources for the production of biodiesel from materials available within the country. It is possible to produce biodiesel from waste/used cooking oils (WCO) that is comparable in quality to that of fresh vegetable oil. Not only does reuse of WCO, which can otherwise harm human health, reduce the burden on the government of treating oily wastewater, disposing of the waste, and maintaining public sewers, it also significantly lowers the production cost of biodiesel. In the process of frying, oil undergoes many reactions, leading to the formation of a number of undesirable compounds, such as polymers, free fatty acids, and many other chemicals. This poses challenges in the transesterification of WCO. This article covers different techniques in the production of biodiesel from WCO. It also compares combustion, emissions, and engine performance characteristics of biodiesel from WCO as well as factors affecting biodiesel production from WCO and its economic feasibility.
Conventional CARs versus modular CARs
Authors: Feldmann Anja , Arndt Claudia , Koristka Stefanie , Berndt Nicole , Bergmann Ralf , Bachmann Michael P. 
Published: September 2019

Abstract
The clinical application of immune effector cells genetically modified to express chimeric antigen receptors (CARs) has shown impressive results including complete remissions of certain malignant hematological diseases. However, their application can also cause severe side effects such as cytokine release syndrome (CRS) or tumor lysis syndrome (TLS). One limitation of currently applied CAR T cells is their lack of regulation. Especially, an emergency shutdown of CAR T cells in case of life-threatening side effects is missing. Moreover, targeting of tumor-associated antigens (TAAs) that are not only expressed on tumor cells but also on vital tissues requires the possibility of a switch allowing to repeatedly turn the activity of CAR T cells on and off. Here we summarize the development of a modular CAR variant termed universal CAR (UniCAR) system that promises to overcome these limitations of conventional CARs.
Skeletal muscle, haematological and splenic volume characteristics of elite breath-hold divers
Authors: Elia Antonis , Wilson Oliver J. , Lees Matthew , Parker Paul J. , Barlow Matthew J. , Cocks Matthew , O’Hara John P. 
Published: September 2019

AbstractPurposeThe aim of the study was to provide an evaluation of the oxygen transport, exchange and storage capacity of elite breath-hold divers (EBHD) compared with non-divers (ND).MethodsTwenty-one healthy males’ (11 EBHD; 10 ND) resting splenic volumes were assessed by ultrasound and venous blood drawn for full blood count analysis. Percutaneous skeletal muscle biopsies were obtained from them. vastus lateralisto measure capillarisation, and fibre type-specific localisation and distribution of myoglobin and mitochondrial content using quantitative immunofluorescence microscopy.ResultsSplenic volume was not different between groups. Reticulocytes, red blood cells and haemoglobin concentrations were higher (+ 24%,p < 0.05; + 9%,p < 0.05; + 3%,p < 0.05; respectively) and mean cell volume was lower (− 6.5%,p < 0.05) in the EBHD compared with ND. Haematocrit was not different between groups. Capillary density was greater (+ 19%;p < 0.05) in the EBHD. The diffusion distance (R95) was lower in type I versus type II fibres for both groups (EBHD,p < 0.01; ND,p < 0.001), with a lower R95for type I fibres in the EBHD versus ND (− 13%,p < 0.05). Myoglobin content was higher in type I than type II fibres in EBHD (+ 27%;p < 0.01) and higher in the type I fibres of EBHD than ND (+ 27%;p < 0.05). No fibre type differences in myoglobin content were observed in ND. Mitochondrial content was higher in type I than type II fibres in EBHD (+ 35%;p < 0.05), with no fibre type differences in ND or between groups.ConclusionsIn conclusion, EBDH demonstrate enhanced oxygen storage in both blood and skeletal muscle and a more efficient oxygen exchange capacity between blood and skeletal muscle versus ND.
A methodology for designing electrification programs for remote areas
Authors: León Javier , Martín-Campo F. Javier , Ortuño M. Teresa , Vitoriano Begoña , Carrasco Luis Miguel , Narvarte Luis 
Published: September 2019

Abstract
One of the UN Sustainable Development Goals is the supply of sustainable energy even where no electrical grid is available. The photovoltaic rural electrification programs are the most common systems implemented in remote areas, especially in developing countries. These programs include the systems installation and their maintenance for a given period. Installation costs and even spare parts costs over time are usually well estimated. However, design and cost estimation of the maintenance systems is a difficult task, whose wrong management has often resulted in the failure of these electrification programs. In this work, a methodology for designing maintenance systems and estimating costs is presented. The methodology includes a mixed integer linear programming model and a rule based expert system. The mathematical programming model allows obtaining the optimal size and accurate cost estimation of a maintenance system, based on precise information about the installed systems. This model is calibrated and validated with real running programs and will be used to get an enlarged data set of simulated cases if needed. The rule based expert system is obtained from the data set applying classification and regression methods with general information about the region and program to be run. It can be used for designing programs or for companies making decisions about being involved in a program to be developed. The methodology has been applied to real Morocco programs.
Baltic Sea eutrophication status is not improved by the first pillar of the European Union Common Agricultural Policy
Authors: Jansson Torbjörn , Andersen Hans E. , Gustafsson Bo G. , Hasler Berit , Höglind Lisa , Choi Hyungsik 
Published: September 2019

Abstract
Agriculture is an important source of nitrogen and phosphorous loads to the Baltic Sea. We study how the European Union’s (EU) Common Agricultural Policy (CAP), and in particular how its first pillar, containing most of the budget and the decoupled farm payments, affects eutrophication. To aid our study, we use three simulation models, covering the agricultural sector in the EU, a hydrological nutrient flow model and a model of eutrophication in the Baltic Sea. We compute changes in key eutrophication indicators in a business-as-usual baseline and in a hypothetical situation where the first pillar of the CAP, containing the direct payments, greening and accompanying measures, is not present. Comparing the outcomes, we find that in the scenario without the first pillar, production and agricultural land use is lower, while yields and fertiliser use per hectare are higher, causing less nitrogen and phosphorous loads (0.5 to 4% depending on the basin) and less eutrophication in the Baltic Sea as net effect. We therefore conclude that the policies of the first pillar of the CAP contribute to increased eutrophication in the Baltic Sea.
Cost–consequence analysis of fluticasone furoate/vilanterol for asthma management in Spain: an analysis based on the Salford Lung Study in asthma
Authors: Vallejo-Aparicio Laura Amanda , Molina Jesús , Ojanguren Iñigo , Viejo Casas Ana , Huerta Alicia , Svedsater Henrik 
Published: September 2019

Abstract

Objectives
The Salford Lung Study in asthma (SLS asthma) is a 12-month, open-label randomised clinical trial comparing clinical effectiveness of initiating once-daily inhaled combination of fluticasone furoate/vilanterol (FF/VI) 184/22 mcg or 92/22 mcg, with continuing optimized usual care (UC) with inhaled corticosteroids (ICS) alone, or in combination with a long-acting β2-agonist (ICS/LABA), in asthmatic patients followed in primary care in the UK. The objective of the analysis is to estimate the economic impact of these results when applied in Spain.

Methods
A 1-year cost–consequence model was populated with SLS asthma, adopting the Spanish National Health System (NHS) perspective. 775,900 of diagnosed asthmatic patients ≥ 18 years old currently managed with UC in Spain were included in the analysis. Effectiveness data included the percentage of patients per Asthma Control Test (ACT) category at 24 and 52 weeks from SLS asthma. Direct costs (pharmacological and per ACT category) were estimated from Spanish public sources and literature (€, 2018). Base case analysis assumed an increased use of FF/VI from 10 to 20% within 1 year. One-way sensitivity analyses were performed.

Results
Within the 775,900 asthmatic patients analysed, substitution of UC with FF/VI was associated with reduced costs due to ACT improvement, leading to potential total annual savings of €4,927,672. Sensitivity analyses ranged from €6,012,975 to €14,783,015 cost savings associated with FF/VI. An analysis considering patients only on ICS/LABA showed potential cost savings of €8,207,448.

Conclusions
The improved asthma control for FF/VI compared with UC observed in SLS asthma could be translated into potential savings for the Spanish NHS. These results may be useful for decision makers.
Partial Bone Formation in Additive Manufactured Porous Implants Reduces Predicted Stress and Danger of Fatigue Failure
Authors: Cheong Vee San , Fromme Paul , Coathup Melanie J. , Mumith Aadil , Blunn Gordon W. 
Published: September 2019

Abstract
New porous implant designs made possible by additive manufacturing allow for increased osseointegration, potentially improving implant performance and longevity for patients that require massive bone implants. The aim of this study was to evaluate how implantation and the strain distribution in the implant affect the pattern of bone ingrowth and how changes in tissue density within the pores alter the stresses in implants. The hypothesis was that porous metal implants are susceptible to fatigue failure, and that this reduces as osteointegration occurs. A phenomenological, finite element analysis (FEA) bone remodelling model was used to predict partial bone formation for two porous (pore sizes of 700 μm and 1500 μm), laser sintered Ti6Al4V implants in an ovine condylar defect model, and was compared and verified against in vivo, histology results. The FEA models predicted partial bone formation within the porous implants, but over-estimated the amount of bone-surface area compared to histology results. The stress and strain in the implant and adjacent tissues were assessed before, during bone remodelling, and at equilibrium. Results showed that partial bone formation improves the stress distribution locally by reducing stress concentrations for both pore sizes, by at least 20%. This improves the long-term fatigue resistance for the larger pore implant, as excessively high stress is reduced to safer levels (86% of fatigue strength) as bone forms. The stress distribution only changed slightly in regions without bone growth. As the extent of bone formation into extensively porous bone implants depends on the level of stress shielding, the design of the implant and stiffness have significant influence on bone integration and need to be considered carefully to ensure the safety of implants with substantial porous regions. To our knowledge this is the first time that the effect of bone formation on stress distribution within a porous implant has been described and characterised.