bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissecting the sustainable tourist experience: sustainable consumption theory and co-creation theory approach
Authors: Fu Xiaoxiao 
Published: December 2024

PurposeTourists are increasingly co-creating meaningful experiences and demonstrating a growing preference for sustainable travel choices. In response, this study investigates the co-created sustainable tourist experience in the Bahamas.Design/methodology/approachDrawing on sustainable consumption theory and co-creation theory, it aimed to develop a more comprehensive framework that encompasses the entire spectrum of the sustainable tourist experience. Data from 25 in-depth interviews and participant observation were analyzed using an inductive-deductive method.FindingsThe analysis revealed multiple aspects of sustainable tourist experience, including sustainable consumption dimensions (environmental, social/individual, social/interactive, economic and institutional) and co-creation phases (co-production, value-in-use and co-creation), along with travel stages (pre-trip, on-site and post-trip). Based on these insights, this study developed a framework that delineates the mechanism of sustainable tourist experience.Practical implicationsThis study outlines managerial implications for the tourism and hospitality industry, highlighting sustainability as central to the tourist experience. Destination planners are encouraged to promote sustainable initiatives that align with tourists’ desires to co-create experiences, enhancing satisfaction, supporting destination sustainability and contributing to long-term industry viability.Originality/valueThe findings contribute to existing research on co-created, across-stage sustainable tourist experiences by presenting a holistic framework that elucidates the underlying mechanisms. This study extends existing conceptual studies by offering a deeper understanding of how tourists interact and co-create with destinations, emphasizing the need to integrate sustainability more effectively into the tourist experience across all stages of travel.
Beyond a buzzword: the agile mindset as a new research construct in organizational psychology
Authors: Augner Tabea , Schermuly Carsten C. 
Published: December 2024

PurposePrevious research on agility has focused on investigating agile practices as external structures (e.g. Scrum, Kanban) that make people do agile. A new line of research is increasingly examining internal structures (e.g. mindsets, attitudes) that cause people to be agile. The purpose of this study is to critically evaluate the agile mindset as a new construct in psychological research.Design/methodology/approachThis two-wave study (N = 411) examined the agile mindset’s factorial, discriminant, and incremental validity. The authors tested whether the agile mindset adds predictive value for occupational behavior (performance and innovative work behavior) and well-being at work (vigor and emotional exhaustion), above well-established internal dispositions, namely core self-evaluation, proactive personality, and prevention vs promotion focus.FindingsThe results indicate that the agile mindset positively predicts performance and innovative work behavior beyond core self-evaluation, proactive personality, and prevention vs promotion focus. Concerning well-being, only positive effects for vigor were found in comparison with prevention vs promotion focus.Practical implicationsThe findings are useful for organizations looking to improve their agility to increase competitiveness in complex environments.Originality/valueThis study underscores the importance of further exploration into the agile mindset, emphasizing its significance in organizational psychology.
Oroxin B Resembles Bisoprolol in Attenuating Beta1‐Adrenergic Receptor Autoantibody‐Induced Atrial Remodelling via the PTEN/AKT/mTOR Signalling Pathway
Authors: Yang Na , Sun Huaxin , Xi Linqiang , Zhang Ling , Lu Yanmei , Wang Qianhui , Cao Jiaru , Song Jie , Tang Baopeng , Shang Luxiang , Zhou Xianhui 
Published: December 2024

ABSTRACTBeta1‐adrenergic receptor autoantibodies (β1‐AAbs) promote atrial remodelling and ultimately lead to the development of atrial fibrillation (AF). Oroxin B is a natural flavonoid glycoside with a variety of biological activities, including anti‐inflammatory and autophagy‐promoting effects, and has therapeutic benefits for a variety of diseases. The aim of this study was to investigate the potential therapeutic role of Oroxin B in the development of β1‐AAb‐induced atrial fibrillation and to elucidate the underlying mechanisms involved. We established a rat model of β1‐AAb‐induced atrial fibrillation via active immunisation. The first stage was divided into three groups: the control group, the β1‐AAb group and the β1‐AAb + bisoprolol group. The second stage was divided into three groups: the control group, the β1‐AAb group and the β1‐AAb + Oroxin B group. Serum levels of β1‐AAbs, atrial tissue levels of cyclic monophosphate (cAMP), atrial electrophysiological parameters, cardiac structure and function, mitochondrial structure, autophagy levels, cardiomyocyte apoptosis and myocardial fibrosis were examined. The results showed that bisoprolol, a β1‐blocker, improved β1‐AAb‐induced atrial electrical remodelling, reduced atrial collagen deposition, ameliorated the increase in LAD and regulated the balance of autophagy and apoptosis in atrial myocytes through the PTEN/AKT/mTOR signalling pathway. Oroxin B, a PTEN agonist, can improve the impairment of autophagy homeostasis and apoptosis in atrial tissue by activating the PTEN/AKT/mTOR signalling pathway, thereby improving atrial structure and electrical remodelling. Moreover, Oroxin B may play a therapeutic role in β1AAb‐induced atrial fibrillation. In conclusion, our results demonstrate the potential therapeutic role of Oroxin B in β1AAb‐induced atrial fibrillation and the underlying mechanisms, suggesting that Oroxin B may be an effective antiarrhythmic medication.
An Improved Transformation‐Associated Recombination Cloning Approach for Direct Capturing of Natural Product Biosynthetic Gene Clusters
Authors: Kurylenko Olena , Palusczak Anja , Luzhetskyy Andriy , Rebets Yuriy 
Published: December 2024

ABSTRACTThe phylum Actinomycetota and genus Streptomyces in particular are the major source for discovery of natural products with diverse chemical structures and a variety of biological activities. Genes encoding biosynthetic pathways for bacterial natural products are grouped together into biosynthetic gene clusters (BGCs). The size of a typical actinobacterial BGC may range from 10 kb to 200 kb, which makes their cloning for heterologous expression a challenging task. Various DNA cloning and assembly methods have been established for capturing BGCs. Among them, the transformation‐associated recombination (TAR) in Saccharomyces cerevisiae remains one of the most cost‐effective, accessible, customisable and precise approaches. However, the drawback of TAR cloning is a need for intensive screening of clones in order to identify one carrying the BGC. In this study, we report a further development of the TAR cloning approach by introducing the direct selection of colonies with BGC of interest based on the yeast killer phenomenon. For this, a new TAR cloning vector system was constructed and the strategy was validated by successful cloning of chelocardin (35 kb) BGC from Amycolatopsis sulphurea and daptomycin BGC (67 kb) from Streptomyces filamentosus. Both BGCs were functionally expressed in a heterologous host, resulting in the production of the corresponding antibiotics. The proposed approach could be widely applied for precise direct cloning of BGCs from the representatives of phylum Actinomycetota and easily adopted for other bacteria.
The Laurentian University Financial Scandal: Accounting and Audit Deficiencies*
Authors: Pilon Marc , Ryan Jo‐Anne 
Published: December 2024

ABSTRACTThis case study investigates the shocking 2021 insolvency and resulting financial scandal at Laurentian University, a publicly funded post‐secondary institution in the province of Ontario, Canada. The case exposes significant weaknesses in internal control, highlights the institution's inability to become financially sustainable, and serves as a warning about the importance of responsible governance. Using publicly available information, the case study focuses on the financial, governance, and auditing elements resulting from the scandal. The Laurentian scandal is a significant Canadian accounting event that merits attention from the accounting community in Canada and beyond because important lessons can be learned about financial management and corporate governance. The case study is best suited for analysis in an upper‐year professional integration undergraduate course or at the graduate level in an assurance course. The case study is also valuable for those in academic governance.
The cost of maternity and neonatal care in Aotearoa New Zealand: A cost analysis by plurality and gestation using a population‐based cohort
Authors: Anderson Karyn , Sadler Lynn , Edlin Richard 
Published: December 2024

BackgroundMaternity services in New Zealand are largely delivered by autonomously practising community midwives. This model of care is unique and may result in differences in the distribution of maternity healthcare utilisation and costs compared to other countries. New Zealand‐specific cost data are needed to inform economic analyses, local policy and healthcare resource planning.AimsTo provide estimates of the average total cost of maternity and neonatal healthcare for New Zealand women and infants, including cost impacts of multiple and preterm births.Materials and MethodsA whole‐of‐population linked dataset, including 262 687 pregnancies resulting in a live birth (from 1 January 2016 to 30 June 2020), was created by combining several sources of healthcare data to calculate an average per‐pregnancy cost of healthcare, taking a public health system perspective, during antenatal, intrapartum, and postnatal periods to one year after birth.ResultsThe mean cost of public healthcare was NZ$19 795 for both maternal and infant care to one year post‐birth. The bulk of this cost was incurred during pregnancy and birth. Mean total cost to one year was NZ$69 895 for twin and NZ$201 448 for higher order multiple compared to singleton pregnancies at NZ$19 098. Mean total healthcare cost decreased as gestation increased.ConclusionsMost of the costs associated with pregnancy and childbirth were incurred during the birth and in the early neonatal period. Costs were disproportionately higher for multiple and preterm births.These cost data can usefully inform policy and assist healthcare decision‐making around reproductive and neonatal technologies.
Race, shaming, and international human rights
Authors: Búzás Zoltán I. , Bassan‐Nygate Lotem 
Published: December 2024

AbstractCan human rights organizations (HROs) shame governments without fueling racism against diasporas or appearing racist? To what extent can shamed governments recover public support lost to shaming by accusing their critics of racism? Employing two U.S.‐based survey experiments involving 6,739 respondents and 11 prominent HRO interviews, we offer three novel findings. First, shaming decreased support for shamed countries (Israel and China) but did not fuel racism (antisemitism and anti‐Asianism). If shamers face a racial dilemma, it is less about how to shame without fueling racism and more about how to shame without appearing racist. Our second finding points toward a solution: when shaming included an anti‐racist cue denouncing racism, respondents perceived it as less racist. Finally, shamed governments can employ racial countershaming to recover some, but not all, of the public support lost to shaming. We contribute to the international relations shaming literature and offer recommendations about racially responsible shaming.
Amplitude‐integrated electroencephalography showed alterations in cerebral activity in monochorionic twins with twin‐to‐twin transfusion syndrome
Authors: Schreiner Christina , Staudt Anna , Neubauer Vera , Kiechl‐Kohlendorfer Ursula , Griesmaier Elke 
Published: December 2024

AbstractAimMonochorionic twins are at higher risk of perinatal mortality and morbidity, primarily due to pregnancy‐related complications, such as twin‐to‐twin transfusion syndrome (TTTS). We aimed to investigate whether amplitude‐integrated electroencephalography (aEEG) signals are different between monochorionic twins with and without TTTS.MethodsThis was a retrospective single‐centre study conducted at Innsbruck Medical University Hospital, Austria. Preterm infants born before 32 weeks of gestation between 6 November 2010 and 6 December 2022 were eligible. The aEEG was analysed for the total maturation score, its component scores and the number of sleep–wake cycles per hour.ResultsWe enrolled 79 monochorionic twin infants (48% male) and 157 dichorionic (62% male) twin infants. We found no differences between these two groups of preterm infants regarding the total maturation and component scores, or the number of sleep wake cycles. Monochorionic twins with TTTS showed significantly lower total maturation scores and individual component scores compared to monochorionic twins without TTTS.ConclusionPreterm infants with TTTS showed differences in neonatal aEEG signals. Whether these differences are caused by prematurity‐related or TTTS‐related factors, such as hemodynamic and metabolic changes due to placental anastomoses, should be investigated in future prospective studies, to gain more insight into this important topic.
Sleep profiles and their associations with adiposity and cardiorespiratory fitness among adolescents
Authors: Bakalár Peter , Janda David , Kostičová Michaela , Kopčáková Jaroslava , Kolarčik Peter , Badura Petr , Gába Aleš 
Published: December 2024

AbstractAimThis study aimed to identify sleep profiles in a representative sample of Slovak adolescents and investigate their associations with adiposity indicators and cardiorespiratory fitness.MethodsData from the 2022 Health Behaviour in School‐aged Children (HBSC) study conducted in Slovakia were analysed. Survey questions on sleep duration and problems from the entire HBSC sample (n = 8906) were used to identify sleep profiles. Associations with adiposity indicators and cardiorespiratory fitness were investigated in a subsample of 924 adolescents (average age 13.3 ± 1.48; 56.2% boys) who completed the HBSC survey, bioimpedance analysis, and 20‐metre shuttle run test.ResultsThree sleep profiles were identified—optimal sleepers, optimal sleepers with sporadic sleep problems and poor sleepers. Crude models showed that poor sleepers had significantly higher body fat percentage and fat mass index, along with lower cardiorespiratory fitness, compared to optimal sleepers. After adjustment, only the association between sleep profiles and cardiorespiratory fitness remained significant.ConclusionThe observed associations between sleep profiles and cardiorespiratory fitness may help better target future intervention resources towards adolescents with low cardiorespiratory fitness levels.
Effect of dietary supplementation with rumen‐protected amino acids, lysine and methionine, on the performance of Comisana ewes and on the growth of their lambs
Authors: Grassi Giulia , Di Gregorio Paola , Capasso Giambattista , Rando Andrea , Perna Anna Maria 
Published: December 2024

AbstractThe purpose of the study was to evaluate the effect of supplementing the diets of Comisana ewes with rumen protected methionine and lysine (RP‐ML) for a duration of 60 days on quantitative–qualitative production of milk, antioxidant parameters of milk and blood, biochemical parameters of blood, and lambs' growth performance. Two groups of 15 ewes with equal average body weight were considered for the trial. The control group was administered a standard diet (Control, C) and the experimental group the standard diet supplemented with 1.5% lysine and 1.0% methionine (Treated, T). Results showed that RP‐ML supplementation positively influenced milk yield, fat and protein content, and casein (p < 0.01). Furthermore, lambs of the T group, compared with those of the C group, showed a 15% higher growth rate during the suckling period of 42 days. Finally, the total antioxidant capacity of milk, measured by ferric reducing antioxidant power and 2,2′‐azino‐bis(3‐ethylbenzotiazolin‐6‐sulfonic acid assay, was significantly lower in T groups (p < 0.05). In conclusion, the results showed that the integration of RP‐ML in ewes could be a valid strategy in order to improve their performances but further investigations are necessary to define the right concentration to be administered to the animals.
Systematic review and meta‐analysis of vancomycin therapeutic level for treatment of vancomycin‐sensitive enterococcal infections
Authors: Katip Wasan , Lee Shaun Wen Huey , Kasatpibal Nongyao , Rayanakorn Ajaree 
Published: December 2024

AbstractAimsEvidence on the optimal targets of vancomycin for treating other Gram‐positive infections apart from methicillin‐resistant Staphylococcus aureus (MRSA) is lacking. This review aims to identify the recommended vancomycin therapeutic level for favourable clinical outcomes among patients infected with vancomycin‐sensitive enterococcal infections.MethodsAnalytical studies describing the vancomycin levels of vancomycin‐sensitive enterococcal infections among adult population were searched. The primary outcome was 30‐day all‐cause mortality, and the secondary outcomes were clinical failure and nephrotoxicity. Study characteristics were extracted and pooled using random‐effects meta‐analysis. The study quality was assessed using the Joanna Briggs Institute critical appraisal tool.ResultsA total of nine retrospective cohorts studies involving 1013 patients with vancomycin‐sensitive enterococci were included. The meta‐analysis found that high area under the curve to minimum inhibitory concentration ratio (AUC/MIC) of vancomycin ≥ 389 mg*h/L significantly lowered the 30‐day mortality (odds ratio [OR], 0.44, 95% confidence interval [CI], 0.26–0.75). Analysis of the target AUC/MIC showed that high vancomycin AUC/MIC (≥ 389–400 mg*h/L) significantly reduced clinical failure rate (OR 0.59, 95% CI 0.37–0.94). The mortality and treatment failure rates did not differ significantly between those with high or low trough levels. Higher vancomycin AUC/MIC and trough levels were significantly associated with increased nephrotoxicity (OR 3.11, 95% CI 1.65–5.89; OR 2.95, 95% CI 1.60–5.44, respectively).ConclusionsThe use of a higher vancomycin AUC/MIC concentration can be effective to reduce 30‐day mortality and clinical failure but this needs to take into consideration the risk of nephrotoxicity. Well‐conducted prospective studies are warranted due to the scarcity of evidence.
Frequency‐adjusted borders ordinal forest: A novel tree ensemble method for ordinal prediction
Authors: Buczak Philip 
Published: December 2024

AbstractOrdinal responses commonly occur in psychology, e.g., through school grades or rating scales. Where traditionally parametric statistical models like the proportional odds model have been used, machine learning (ML) methods such as random forest (RF) are increasingly employed for ordinal prediction. With new developments in assessment and new data sources yielding increasing quantities of data in the psychological sciences, such ML approaches promise high predictive performance. As RF does not inherently account for ordinality, several extensions have been proposed. A promising approach lies in assigning optimized numeric scores to the ordinal response categories and using regression RF. However, these optimization procedures are computationally expensive and have been shown to yield only situational benefit. In this work, I propose Frequency‐Adjusted Borders Ordinal Forest (fabOF), a novel tree ensemble method for ordinal prediction forgoing extensive optimization while offering improved predictive performance in simulation and an illustrative example of student performance. To aid interpretation, I additionally introduce a permutation variable importance measure for fabOF tailored towards ordinal prediction. When applied to the illustrative example, an interest in higher education, mother's education, and study time are identified as important predictors of student performance. The presented methodology is made available through an accompanying R package.
BCR::ABL1‐induced mitochondrial morphological alterations as a potential clinical biomarker in chronic myeloid leukemia
Authors: Suzuki Kohjin , Watanabe Naoki , Torii Satoru , Arakawa Satoko , Ochi Kiyosumi , Tsuchiya Shun , Yamada Kazuhiro , Kawamura Yoko , Ota Sadao , Komatsu Norio , Shimizu Shigeomi , Ando Miki , Takaku Tomoiku 
Published: December 2024

AbstractThe BCR::ABL1 oncogene plays a crucial role in the development of chronic myeloid leukemia (CML). Previous studies have investigated the involvement of mitochondrial dynamics in various cancers, revealing potential therapeutic strategies. However, the impact of BCR::ABL1 on mitochondrial dynamics remains unclear. In this study, we demonstrated that BCR::ABL1 is sufficient to induce excessive mitochondrial fragmentation by activating dynamin‐related protein (DRP)1 through the mitogen‐activated protein kinase (MAPK) pathway. Leukocytes obtained from patients with CML and the BCR::ABL1‐positive cell lines exhibited increased mitochondrial fragmentation compared to leukocytes obtained from healthy donors and BCR::ABL1‐negative cells. Furthermore, the analysis of BCR::ABL1‐transduced cells showed increased phosphorylation of DRP1 at serine 616 and extracellular signal‐regulated kinase (ERK) 1/2. Moreover, the inhibition of DRP1 and upstream mitogen‐activated extracellular signal‐regulated kinase (MEK) 1/2 suppressed mitochondrial fragmentation. Strikingly, DRP1 inhibition effectively reduced the viability of BCR::ABL1‐positive cells and induced necrotic cell death. Additionally, a label‐free artificial intelligence‐driven flow cytometry successfully identified not only the BCR::ABL1‐transduced cells but also peripheral leukocytes from CML patients by assessing mitochondrial morphological alterations. These findings suggested the crucial role of BCR::ABL1‐induced mitochondrial fragmentation in driving BCR::ABL1‐positive cell proliferation, and the potential use of mitochondrial morphological alterations as a clinical biomarker for the label‐free detection of CML cells.
Photodynamische Therapie in der Dermatologie: Bewährte und neue Indikationen
Authors: Balakirski Galina , Lehmann Percy , Szeimies Rolf‐Markus , Hofmann Silke C. 
Published: December 2024

ZusammenfassungDie photodynamische Therapie (PDT) ist international zur Behandlung von In‐situ‐Formen des keratinozytären Hautkrebses (aktinische Keratosen, Morbus Bowen, Basalzellkarzinome) zugelassen. Für diese Indikationen bestehen standardisierte Behandlungsprotokolle mit Schmalspektrum‐Lichtquellen oder (künstlichem) Tageslicht, die zu Heilung, geringer Rezidivrate der Läsionen und sehr gutem kosmetischen Ergebnis führen. Die Tageslicht‐PDT ist dabei im Hinblick auf die deutlich geringere Schmerzhaftigkeit und damit verbundene höhere Akzeptanz durch die Patienten der konventionellen PDT überlegen.Neuere Indikationen, für die noch keine Zulassung vorliegt, für die die Studienlage aber ausreichende Wirksamkeit belegt, sind entzündliche (Lichen sclerosus, Akne) und infektiöse Dermatosen (Viruswarzen, kutane Leishmaniose, atypische Mykobakteriose). Darüber hinaus wird die PDT zunehmend in der ästhetischen Dermatologie zur Hautverjüngung eingesetzt.