bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virulence determinants in genetically heterogeneous populations of Aeromonads recovered from an urban lagoon
Authors: de Melo Rodrigues Sobral Mariana , Barreto Camila , Bianco Kayo , de Oliveira Samara Sant'Anna , Clementino Maysa Mandetta 
Published: March 2019

Abstract
The diversity and distribution of Aeromonas spp. associated with virulence profiles from the Rodrigo de Freitas Lagoon were investigated using phylogenetic analysis of gyrB/rpoB gene sequences for speciation. The concatenated gyrB/rpoB gene sequences clustered into five species: Aeromonas punctata/caviae (n = 37), A. hydrophila (n = 10), A. dhakensis (n = 16), A. jandaei (n = 1) and A. enteropelogenes/trota (n = 3). The virulence genes (atc/aerA/hlyA/asp/amp) resulted in 19 virulence profiles, distributed heterogeneously among the five Aeromonas species. Out of the 67 isolates, 16% presented five distinct profiles carrying four virulence genes and 7% showed all genes investigated. The hemolytic genes were detected as follows: act 54% (37/67), aerA 36% (24/67), hlyA 26% (18/67) and proteolytic genes such as asp 36% (24/57) and amp in 85% (57/67) were widely distributed in lagoon sampling stations. Meanwhile, 88% (59/67) and 92% (62/67) of the isolates showed hemolytic and proteolytic activity, respectively. Our results demonstrated that concatenated sequences of the gyrB and rpoB genes showed to be an adequate approach for the Aeromonas speciation and prevalence. The high heterogeneity of virulence genes among the species resulted in several virulence profiles, as well as high percentages of hemolytic and proteolytic activity, demonstrating the necessity of further epidemiological surveys of Aeromonas species pathogenicity in an aquatic recreational lagoon.
Biosimilars of Adalimumab in Inflammatory Bowel Disease: Are we Ready for that?
Authors: Argollo Marjorie , Fiorino Gionata , Gilardi Daniela , Furfaro Federica , Roda Giulia , Loy Laura , Allocca Mariangela , Peyrin-Biroulet Laurent , Danese Silvio 
Published: March 2019

Introduction:
Biosimilars present a considerable potential to reduce costs related to clinical management
allowing health-care providers to reinvest this money, leading to a wider access to an effective biological
treatment with monoclonal antibodies (mAb). Infliximab biosimilars have already been incorporated in daily
clinical practice and are currently used in all indications for which the reference product (RP) was approved.

Areas covered:
In the next few years, also adalimumab biosimilars will become available for the treatment of
inflammatory bowel disease (IBD). In fact, several of them (ABP501, BI 695501, GP2017, and SB5) have been
approved by the European Medicines Agency (EMA) with the same indications of the reference product (Humira
®). Initial preclinical data proved a strong similarity between all biosimilars and the RP. Moreover, phase 3
studies in rheumatoid arthritis and psoriasis showed no differences in terms of efficacy, safety, and immunogenicity.
Data on IBD patients are urgently needed.

Expert opinion:
Biosimilars of adalimumab showed equivalent clinical efficacy to the RP in other immunemediated
diseases. However, defining the ideal patient’s profile to receive or to be switched to a biosimilar,
choosing one biosimilar vs. another, or cross-switching among biosimilars, will become the next challenge in
IBD.
An Update on the Association of Protein Kinases with Cardiovascular Diseases
Authors: Amin Fakhra , Ahmed Azaj , Feroz Anna , Khaki Peerzada Shariq Shaheen , Khan Mohd Shahnwaz , Tabrez Shams , Zaidi Syed Kashif , Abdulaal Wesam H. , Shamsi Anas , Khan Wajihullah , Bano Bilqees 
Published: March 2019

Background:Protein kinases are the enzymes involved in phosphorylation of different proteins which leads to functional changes in those proteins. They belong to serine-threonine kinases family and are classified into the AGC (Protein kinase A/ Protein kinase G/ Protein kinase C) families of protein and Rho-associated kinase protein (ROCK). The AGC family of kinases are involved in G-protein stimuli, muscle contraction, platelet biology and lipid signaling. On the other hand, ROCK regulates actin cytoskeleton which is involved in the development of stress fibres. Inflammation is the main signal in all ROCK-mediated disease. It triggers the cascade of a reaction involving various proinflammatory cytokine molecules.Methods:Two ROCK isoforms are found in mammals and invertebrates. The first isoforms are present mainly in the kidney, lung, spleen, liver, and testis. The second one is mainly distributed in the brain and heart.Results:ROCK proteins are ubiquitously present in all tissues and are involved in many ailments that include hypertension, stroke, atherosclerosis, pulmonary hypertension, vasospasm, ischemia-reperfusion injury and heart failure. Several ROCK inhibitors have shown positive results in the treatment of various disease including cardiovascular diseases.Conclusion:ROCK inhibitors, fasudil and Y27632, have been reported for significant efficiency in dropping vascular smooth muscle cell hyper-contraction, vascular inflammatory cell recruitment, cardiac remodelling and endothelial dysfunction which highlight ROCK role in cardiovascular diseases.
A Stack Autoencoders Based Deep Neural Network Approach for Cervical Cell Classification in Pap-Smear Images
Authors: Singh Sanjay K. , Goyal Anjali 
Published: March 2019

Background:
Early detection of cervical cancer may give life to women all over the
world. Pap-smear test and Human papillomavirus test are techniques used for the detection and prevention
of cervical cancer.

Objective:
In this paper, pap-smear images are analysed and cells are classified using stacked autoencoder
based deep neural network. Pap-smear cells are classified into 2 classes and 4 classes. Twoclass
classification includes classification of cells in normal and abnormal cells while four-class
classification includes classification of cells in normal cells , mild dysplastic cells, moderate dysplastic
cells and severe dysplastic cells.

Methods:
The features are extracted by deep neural networks based on their architecture. Proposed
deep neural networks consist of three stacked auto encoders with hidden sizes 512, 256 and 128, respectively.
Softmax used as the outer layer for the classification of pap smear cells.
Results: Average accuracy achieved for 2-class classification among normal and abnormal cells is
98.2 % while for 4-class classification among normal, mild, moderate and severe dysplastic cells is
93.8 % respectively.

Conclusion:
The proposed approach avoids image segmentation and feature extraction applied by
previous works. This study highlights deep learning as an important tool for cells classification of
pap-smear images. The accuracy of the proposed method may vary with the different combination of
hidden size and number of autoencoders.
Sepsis: From Historical Aspects to Novel Vistas. Pathogenic and Therapeutic Considerations
Authors: Magrone Thea , Jirillo Emilio 
Published: March 2019

Background:Sepsis is a clinical condition due to an infectious event which leads to an early hyper-inflammatory phase followed by a status of tolerance or immune paralysis. Hyper-inflammation derives from a massive activation of immune (neutrophils, monocytes/macrophages, dendritic cells and lymphocytes) and non-immune cells (platelets and endothelial cells) in response to Gram-negative and Gram-positive bacteria and fungi.Discussion:A storm of pro-inflammatory cytokines and reactive oxygen species accounts for the systemic inflammatory response syndrome. In this phase, bacterial clearance may be associated with a severe organ failure development. Tolerance or compensatory anti-inflammatory response syndrome (CARS) depends on the production of anti-inflammatory mediators, such as interleukin-10, secreted by T regulatory cells. However, once triggered, CARS, if prolonged, may also be detrimental to the host, thus reducing bacterial clearance.Conclusion:In this review, the description of pathogenic mechanisms of sepsis is propaedeutic to the illustration of novel therapeutic attempts for the prevention or attenuation of experimental sepsis as well as of clinical trials. In this direction, inhibitors of NF-κB pathway, cell therapy and use of dietary products in sepsis will be described in detail.
Peranan Wisdom terhadap Subjective Well-Being pada Dewasa Awal
Authors: Intani Zahra Farida , Indati Aisah 
Published: March 2019

Subjective well-being is one of the topics of positive psychology studies related to one’s quality of life, while wisdom is the highest ability that one can have from their life experiences. This study aimed to determine the contribution of wisdom on subjective well-being in early adulthood. The hypothesis proposed in this study was wisdom contributes positively toward subjective well-being in early adulthood. Participants of the study (N = 158) were undergraduate students (female = 98, male = 60) who are working on their final project (thesis). Data was collected using Skala Kesejahteraan Subjektif developed by Utami and the adaptation of The Three Dimensional Wisdom Scale (3D-WS). Result showed that wisdom significantly predicted subjective well-being in positive direction.
Toward a Distributed Carbon Ledger for Carbon Emissions Trading and Accounting for Corporate Carbon Management
Authors: Tang Qingliang , Tang Lie Ming 
Published: March 2019

ABSTRACT
Greenhouse gas (GHG) emissions control requires coordinated efforts and collaboration at all levels of governmental bodies, non-for-profit organizations, and private sectors. However, the target is difficult to achieve due to challenges arising from conflicts of interest and lack of trust between stakeholders. Thus, we propose a distributed carbon ledger (DCL) system using blockchain technology. Our analysis suggests that the adoption of DCL not only strengthens the corporate accounting system for carbon asset management but also fits within existing market-based emissions trading schemes (ETSs). Blockchain-enabled DCL allows the integration of national emission trading schemes (ETSs) and corporate carbon asset management into a synthetic single mechanism.
JEL Classifications: M41; O44.
The Utilization of Zakah Productive towards Micro-Business Growth and Mustahik Welfare
Authors: Nasution Muhammad Irfan , Prayogi Muhammad Andi 
Published: March 2019

One of the basic laws that the zakat seems to be ordered is the word of Allah SWT QS. At-Taubah verse 103, The study aims to analyze the effect of productive Zakat, Infak, Sedekah (ZIS) to the micro-business growth of mustahik of Muhammadiyah Society in Medan City, micro-business growth towards mustahik welfare of Muhammadiyah Society in Medan City, and simultaneously effect of Productive Zakat, Infak, Sedekah (ZIS) and micro-business growth to the mustahik welfare of Muhammadiyah society in Medan City. This research used quantitative descriptive analysis, the sample was selected by using quota sampling, and the data analysis technique used was multiple linear regression analysis. The results showed that there is a positive and significant influence between productive Zakat and mustahik welfare, there is a relationship between micro-business growth and mustahik welfare and also simultaneously there is a relationship between productive Zakat and the micro-business growth towards mustahik welfare of Muhammadiyah society in Medan city. The implication of this study is emphasizing the distribution of Zakat that more prioritizing on Productive Zakat.
AKTIVITAS DAKWAH DAN KEPAHLAWANAN TUANKU TAMBUSAI
Authors: Ginda Ginda 
Published: March 2019

Tuanku Tambusai seorang anak negeri Riau telah ditetapkan sebagai pahlawan nasional karena jasa dan perjuangan yang dilakukan melawan kolonial Belanda. Sebagai pahlawan Nasional, sisi heroiknya melawan Belanda telah banyak mendapat perhatian, namun sisi keagamaandan dakwah sangat sedikit yang dikaji, sementara motif perlawanan dan perjuangannya terhadap Belanda tidak terlepas dari perspektif dan keulamaan beliau yang memandang Belanda adalah penguasa-penguasa zalim yang harus di tumpas. Dakwah dan perjuangan mengusir Belanda merupakan dua “ sisi mata uang” dalam kepribadian Tuanku Tambusai. Semangat Dakwah dan perjuangan melawan Belanda telah membanya sebagai tokoh yang memberikan kontriubusi yang signifikan dalam penyebaran Islam di daerah, Sumatera Barat, Sumatera Utara dan Propinsi Riau.
STRATEGI PENGELOLAAN ZAKAT BERBASIS PEMBERDAYAAN MASYARAKAT MISKIN PADA BADAN AMIL ZAKAT NASIONAL (BAZNAS) KOTA PEKANBARU
Authors: Artis Artis 
Published: March 2019

Penelitian ini dilakukan pada Badan Amil Zakat Nasional (BAZNAS) Kota Pekanbaru. Permasalahan dalam penelitian ini adalah bagaimana strategi pengelolaan zakat berbasis pemberdayaan masyarakat miskin yang diterapkan oleh Badan Amil Zakat Nasional (BAZNAS) Kota Pekanbaru dengan tujuan agar strategi pengelolaan tersebut dapat diketahui. Informan penelitian ini berjumlah 10 orang. Metode pengumpulan data dilakukan melalui observasi, wawancara, dan dokumentasi dan dianalisis secara deskriptif kualitatif. Berdasarkan metode di atas dapat ditemukan bahwa strategi pengelolaan zakat berbasis pemberdayaan masyarakat miskin pada Badan Amil Zakat Nasional (BAZNAS) Kota Pekanbaru dilakukan tahapan perencanaan, pengidentifikasian, pendistribusian, pengawasan dan evaluasi. Perencanaan dibentuk dengan cara menyusun program kerja yang berpihak pada masyarakat miskin. Pengidentifikasian dilakukan dengan cara pengumpulan data muzakki dan mustahik terutama orang-orang miskin. Pendistribusian disalurkan dengan cara menyalurkan ke sektor produktif dengan tujuan agar masyarakat miskin menjadi berdaya. Pengawasan dilakukan dengan cara menjamin tercapainya pengentasan kemiskinan sesuai rencana. Sedangkan evaluasi dilakukan dengan cara penilaian dalam mengawasi proses agar tidak terjadi penyimpangan. Cara tersebut terkoordinir dengan sistematis, meski masih ada hal-hal yang harus dibenahi. Namun, secara keseluruhan strategi pengelolaan zakat berbasis pemberdayaan masyarakat miskin telah berjalan sesuai dengan ketentuan syari’at agama Islam, Undang-Undang (UU) zakat dan ilmu dalam pengelolaan zakat.
FENOMENA EKSPLOITASI PEREMPUAN OLEH MEDIA
Authors: Aslati Aslati , Silawati Silawati 
Published: March 2019

Setelah Nabi Muhammad SAW lahir dan membawa Risalah Islam Nabi berjuang untuk mengentaskan jurang kehinaan perempuan kepada kedudukan yang mulia dan terhormat. Kehadiran agama Islam menjadi semacam oase yang menyudahi dahaga kaum wanita yang mengharap adanya penetapan hak dan perlakuan yang setara antara laki-laki dan perempuan. Islam datang untuk memberi penghargaan serta penghormatan yang sangat tinggi kepada kaum perempuan. Di sisi lain saat ini perkembangan media massa yang tidak terbendung cenderung melakukan eksploitasi terhadap kaum perempuan. Berbagai media baik cetak maupun elektronik serta media-media online untuk menarik minat khalayak menjadikan perempuan sebagai subjek dan objek paling depan pada media tersebut. Pemberitaan oleh media menjadikan perempuan sebagai daya tarik media itu sendiri. Eksploitasi perempuan oleh media seolah-oleh dijadikan sebagai softpornograpy. Besarnya porsi pemberitaan mengenai seluk beluk perempuan di media seolah-olah membuat laku media tersebut. Kesimpulan bahwa di dalam Islam Perempuan dijaga dengan baik, diperlakukan dengan baik, ditinggikan derajatnya. Sebaliknya kedudukan perempuan dalam media selalu dieksploitasi demi tujuan-tujuan keuntungan baik individu maupun kelompok.
MARKETING POLITIK REKRUTMEN POLITISI PEREMPUAN DI PROVINSI RIAU (STUDI KASUS PARTAI SOLIDARITAS INDONESIA DAN PARTAI NASIONAL DEMOKRAT)
Authors: Yesicha Chelsy 
Published: March 2019

Meski Riau dinobatkan memiliki politisi perempuan terbanyak di parlemen periode 2014-2019 di Indonesia, partai tetap perlu melakukan marketing politik guna merekrut politisi perempuan di Pemilu 2019. Partai Solidaritas Indonesia dan Partai Nasional Demokrat merupakan partai yang berani mengusung tema “tanpa mahar” menjadi fokus kajian guna mengetahui image building dan media komunikasi yang digunakan dalam merekrut politisi perempuan di wilayah Riau. Pendekatan studi kasus jamak memperlihatkan perbedaan antara kedua partai dengan pengumpulan data yang digunakan yaitu wawancara, observasi dan dokumentasi akhirnya menyimpulkan bahwa Image Building Partai Solidaritas Indonesia Riau mengutamakan keterbukaan dan keinovatifan bagi mata rantai pengerak perempuan Riau untuk berpolitik sedangkan Partai Nasional Demokrat Riau menampilkan realitas “politik tanpa mahar” bagi partai melalui keberhasilannya, role model dihadirkan untuk mempengaruhi perempuan Riau dalam melaksanakan Restorasi Indonesia. Komunikasi bermedia yang dilakukan keduanya unggulan bertaut pada akun DPP dan interpersonal dinilai efektif dalam merekrut politisi perempuan Riau
Calcium-Phosphate Metabolism Disorders in Patients with Renal Failure Clinical Significance, Diagnosis and Treatment
Authors: Grozeva V. , Kundurzhiev A. 
Published: March 2019

Abstract
Chronic kidney diseases (CKD) are commonly associated with calcium and phosphorus metabolism disorders. The general term of “renal osteodystrophy” (ROD) encompasses a complex spectrum of abnormalities in bone and mineral metabolism in CKD. This is one of the most serious and debilitating complications of CKD. It is related to disproportionately high direct and indirect costs of healthcare, thus posing a major burden on society. The development of ROD begins too early in the course of CKD. Some mechanisms involved in the pathogenesis of ROD are reduced calciferol production, calcium deficiency and hyperphosphatemia. Clinically, ROD occurs with varied manifestations – osteomalacia, osteoporosis, adynamic bone disease. The diagnosis and the treatment are a challenge for the physician and effort should be made to prolong the duration and quality of life of the affected patients.
Architectural Theory and Analytic Philosophy in the Interwar Period
Authors: Jász Borbála 
Published: March 2019

Abstract
The basis of the connection between analytic philosophy and architecture theory was developed in the interwar period. The results of analytic philosophy – especially the neo-positivism of Vienna Circle – and modern, functionalist architecture theory were utilized in an interdisciplinary approach. The comparison was based on language puzzles, science-based building processes, the method of justification and verification, and designing an artificial language in order to express the theoretical (philosophical) and the practical (architectural) approach as well. The functionality was based on the modern way of architectural thinking that relied on the results of Carnapian neo-positivism. Interpreting modern architecture is possible by referring to the keywords of logical positivism: empiricism, logic, verification, unity of language, and science.
In my paper, I first list the bases of the comparison between the philosophy of the Vienna Circle and the architecture theory of the interwar period – the Bauhaus and Le Corbusier. In the 2nd and 3rd sections, I show the dialectical succession between form and function. After that, I discuss the aesthetic verification of the turn of the century and the scientific justification of the interwar period. I focus on the interwar period with the positivist approach and the theory of the ‘new architecture’. I emphasize the importance of the language of science and the machine paradigm – in contrast to historicism.
The ‘Roma Question’ in Slovakia
Authors: Macsó Kinga 
Published: March 2019

Abstract
Slovakia belongs to those states with a high number of Romani in terms of population – of the population of about 5.3 million, 480 to 520 thousand people have Romani origin. In Slovakia, only since 1999 have the Gypsies been able to call themselves Roma. In the 1991, 2001, and 2011 censuses, the Romani could decide on their affiliation, they could be considered Roma citizens, but only a few people made use of this right. Only 25% of the Roma ethnic group called themselves Roma, while the majority referred to themselves as Slovakian or Hungarian; so, these demographic data do not reflect reality. The so-called ‘Atlas’-es show a more significantly accurate picture. The creators of these worked together with the local social workers who knew the local Roma communities well in the given settlements. Approximately half of the Romani living in Slovakia were able to change socially to some extent and adapt to the society’s majority. The rest of the Roma minority live isolated in some parts of the city, on the edge of the city, or in the nearby. These communities are characterized by social and ethnic isolation, which may be different in some specific cases. According to different indicators, they are divided into segregated, separated, integrated focused, and integrated scattered groups. Since the year 2003, the state has introduced various social reforms. Local governments have also joined the state-initiated reforms. They create various special projects for their own Roma communities in order to help their advancement.
A Successful Example of Complex Country Branding: The ‘E-Estonia’ Positioning Concept and Its Relation to the Presidency of the Council of the EU
Authors: Papp-Váry Árpád Ferenc 
Published: March 2019

Abstract
Estonia held the presidency of the Council of the European Union for six months from 1 July to 31 December 2017. This was a great opportunity to strengthen and shape the country image, also known as the country brand. They do have something to build on: there have been very few countries in recent years and decades where country branding was so conscious. It was a brave choice: in the early 2000s, they decided that they would become E-Estonia. This is not just a means to communicate but also involves policies and tangible developments regarding electronics, IT, and brand new technologies in order to build the most advanced digital society of Europe and the world.
But how did this appear during the EU Presidency and how are Estonian citizens involved in branding? This rather lengthy case study explores the concept as a good practice, also setting an example for other countries.
Deterioration Causes Evaluation of Third Generation Cellular LTE Services for Moving Unmanned Terrestrial and Aerial Systems
Authors: Brodņevs Deniss , Kutins Aleksandrs 
Published: March 2019

Abstract
Well-deployed cellular networks offer a cheap wireless solution for the control channel deployment of Remote-Control Vehicles (RCV) and Unmanned Aerial Vehicles (UAV). However, a cellular data transfer service performance is affected by a different kind of User Equipment (UE) mobility. Operating conditions of UAV imply working at different altitudes, variable velocities with accelerations/decelerations and rapidly changed antennas angular position, which lead the wireless signal to be prone to negative effects. Available field measurement studies are not sufficient to provide excessive information on degradation problem causes for UEs moving along a complex trajectory. This paper presents an evaluation of the service quality of live operational 3G and LTE networks for both ground moving and flying UE. It has been found that antennas angular position variations in 3D (for example, during UAV manoeuvers) increase data transfer latency and jitter. Moreover, this effect in conjunction with higher interference at high altitudes may partially or fully block the data transfer service. This paper has been prepared to draw attention to the problem that makes the cellular data transfer service unusable for highly-manoeuvrable UAVs.