bluuebunny/crossref_metadata_2025_split huggingface dataset:
RIPK1 Polymorphisms Alter the Susceptibility to Cervical Cancer among the Uyghur population in China
Authors: Han Lili , Husaiyin Sulaiya , Ma Chunhua , Niyazi Mayinuer 
Published: October 2019

Abstract
Background: RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK1 polymorphisms and cervical cancer risk among the Uyghur population.
Methods: We performed a case-control study including 342 cervical cancer patients and 498 age-matched healthy controls. Five RIPK1 genetic variants (rs6907943, rs3736724, rs2077681, rs9503400 and rs17548629) were genotyped with Agena MassARRAY platform. The associations between RIPK1 polymorphisms and cervical cancer risk were assessed under multivariate logistic regression models.
Results: The results showed rs3736724 and rs2077681 were significantly associated with cervical cancer risk under various genetic models ( p < 0.05). The stratified analysis indicated that the relationships of rs2077681 and rs17548629 with cervical cancer risk were statistically significant in the subgroups of elderly individuals (age > 43 years) and stage. Additional, rs3736724 decreased the cervical cancer risk among the subjects aged ≤ 43 years in codominant model ( p = 0.043). Rs6907943 and rs9503400 could influence the susceptibility of cervical cancer for the patients with different stage ( p < 0.05).
Conclusion: Our findings demonstrated that RIPK1 polymorphisms are associated with cervical cancer susceptibility among the Uyghur population in China, and may be involved in the development of cervical cancer.
15-lncRNAs-based classifier-clinicopathologic nomogram improves the prediction of recurrence in patients with hepatocellular carcinoma
Authors: Zhang Qiong , Ning Gang , Jiang Hongye , Huang Yanlin , Piao Jinsong , Zhen Chen , Tan Xiaojun , Liu Genglong 
Published: October 2019

Abstract
Background: Our study aims to develop an lncRNAs-based classifier and a nomogram incorporating the genomic signature and clinicopathologic factors to help to improve the accuracy of recurrence prediction for hepatocellular carcinoma(HCC) patients.Methods: The lncRNAs profiling data of 374 HCC patients and 50 normal healthy controls were downloaded from the Cancer Genome Atlas (TCGA). Using univariable Cox regression and Least absolute shrinkage and selection operator (LASSO) analysis, we developed 15-lncRNAs-based classifier and compared our classifier to existing six-lncRNAs signature. Besides, a nomogram incorporating the genomic classifier and clinicopathologic factors was also developed. The predictive accuracy and discriminative ability of the genomic-clinicopathologic nomogram were determined by a concordance index (C-index) and calibration curve and were compared with TNM staging system by C-index, receiver operating characteristic (ROC) analysis. Decision curve analysis (DCA) was performed to estimate clinical value of our nomogram.Results: Fifteen relapse-free survival (RFS) -related lncRNAs were identified and the classifer, consisting of the identified15 lncRNAs, could effectively classify patients into high-risk and low-risk subgroup. The prediction accuracy of the 15-lncRNAs-based classifier for predicting 2- year and 5-year RFS were 0.791 and 0.834 in the training set and 0.684 and 0.747 in the validation set, which was better than the existing six-lncRNAs signature. Moreover, the AUC of genomic-clinicopathologic nomogram in predicting RFS were 0.837 in the training set and 0.753 in the validation set, and the C-index of the genomic-clinicopathologic nomogram was 0.78 (0.72-0.83) in the training set and 0.71 (0.65-0.76) in the validation set, which was better than traditional TNM stage and 15-lncRNAs-based classifier. Decision curve analysis further demonstrated that our nomogram had larger net benefit than TNM stage and 15-lncRNAs-based classifier. Conclusion: Compared to TNM stage, the 15-lncRNAs-based classifier-clinicopathologic nomogram is a more effective and valuable tool to identify HCC recurrence and may aid in clinical decision-making.
Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients
Authors: Kishimoto Takumi , Fujimoto Nobukazu , Ebara Takeshi , Omori Toyonori , Oguri Tetsuya , Niimi Akio , Yokoyama Takako , Kato Munehiro , Usami Ikuji , Nishio Masayuki , Yoshikawa Kosho , Tokuyama Takeshi , Tamura Mouka , Yokoyama Yoshifumi , Tsuboi Ken , Matsuo Yoichi , Xu Jiegou , Takahashi Satoru , Abdelgied Mohamed , Alexander William T. , Alexander David B , Tsuda Hiroyuki 
Published: October 2019

Abstract
Background Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammatory response. Repeated exposure to asbestos fibers results in a prolonged inflammatory response and cycles of tissue damage and repair. The inflammation-associated cycles of tissue damage and repair are intimately involved in the development of asbestos-associated cancers. Macrophages are a key component of asbestos-associated inflammation and play essential roles in the etiology of a variety of cancers. Macrophages are also a source of C-C motif chemokine ligand 2 (CCL2), and a variety of tumor-types express CCL2. High levels of CCL2 are present in the pleural effusions of mesothelioma patients, however, CCL2 has not been examined in the serum of mesothelioma patients.Methods The present study was carried out with 50 MPM patients and 356 subjects who were possibly exposed to asbestos but did not have disease symptoms and 41 healthy volunteers without a history of exposure to asbestos. The levels of CCL2 in the serum of the study participants was determined using ELISA.Results Levels of CCL2 were significantly elevated in the serum of the MPM patients, and the increase was dependent on the stage of the disease.Conclusions Our findings are consistent with the premise that the CCL2/CCR2 axis and myeloid-derived cells play an important role in MPM and disease progression. Several, but not all, studies of serum CCL2 levels in patients with other types of cancer also report elevated serum CCL2, and many of these studies report that the increased levels of serum CCL2 are associated with the stage of the disease. Therapies are being developed that target CCL2/CCR2 and tumor resident myeloid cells, and clinical trials are being pursued that use these therapies as part of the treatment regimen. The results of trials with patients with a similar serum CCL2 pattern as MPM patients will have important implications for the treatment of MPM.
Role of high-dose salvage radiotherapy for oligometastases of the localised abdominal/pelvic lymph nodes: A retrospective study
Authors: Ito Makoto , Kodaira Takeshi , Koide Yutaro , Okuda Takahito , Mizumatsu Shinichiro , Oshima Yukihiko , Takeuchi Arisa , Mori Toshie , Abe Souichirou , Asai Ayumi , Suzuki Kojiro 
Published: October 2019

Abstract
Background: Abdominal/pelvic lymph node (LN) oligometastasis is a pattern of failure that is observed occasionally. Although radiotherapy may be useful for salvage therapy, the optimal prescription dose has not yet been clarified. This study assessed the efficacy of high-dose radiotherapy.
Methods: Between 2008 and 2018, the medical records of 113 patients with 1–5 abdominal/pelvic LN oligometastases treated with definitive radiotherapy at 4 institutes were retrospectively analysed. The exclusion criteria were non-epithelial tumours, uncontrolled primary lesions, palliative intent, and re-irradiation. The prescription dose was evaluated by using the equivalent dose in 2 Gy fractions (EQD2); patients with EQD2 ≥60 Gy were the high-dose group. Kaplan-Meier analysis was used to evaluate the endpoints of overall survival (OS), local control (LC), and progression-free survival (PFS). Univariate log-rank and multivariate Cox proportional hazards model analyses were performed to clarify predictive factors for each endpoint. Toxicity rates were compared between the high-dose and low-dose groups.
Results: The primary tumour sites included the colorectum (n = 28), uterine cervix (n = 27), endometrium (n = 15), and ovaries (n = 10). The 2-year OS, LC, and PFS rates were 63.1%, 59.7%, and 19.4%, respectively. On multivariate analyses, solitary oligometastasis, high-dose radiotherapy, and long disease-free interval were associated with significantly favourable OS (hazard ratio [HR]: 0.48, p = 0.02), LC (HR: 0.93, p < 0.001), and PFS (HR: 0.59, p = 0.01), respectively. Although high-dose radiotherapy did not significantly improve the 2-year OS of the entire cohort (74.8% vs. 52.7% in the high-dose vs. low-dose group; p = 0.08), it showed a significant difference on subgroup analysis for solitary oligometastasis (88.8% vs. 56.3%; p = 0.009). Late grade ≥3 toxicity included ileus in 7 cases (6%) and gastrointestinal bleeding in 4 (4%). There was no significant association between the irradiation dose and toxicity incidence.
Conclusions: Salvage radiotherapy was feasible for oligometastasis of the abdominal/pelvic LNs. For solitary oligometastasis, the high-dose group showed favourable results considering LC and OS.
Taxonomic Composition and Population Level of the Prosthetic Bed Mucosa Microbiota in Case of Dentition Defects in Patients Wearing Partial Dentures
Authors: Ozhogan Zinoviy , Yasinskyi Mykola , Belikov Olexander , Levandovskyi Roman 
Published: October 2019

The article considers the taxonomic composition and the population level of the oral cavity microbiota and changes in their characteristics after prosthetic rehabilitation with partial removable dentures. In the patients with partial loss of teeth wearing conventional removable dentures, the taxonomic composition of the gingiva microbiota changes due to the biotope contamination with opportunistic S. aureus and yeast-like fungi of the Candida genus, S. haemolyticus, K. pneumoniae, enterobacteria (E.coli, K.pneumoniae, E.cloacae), B.catarralis, M.lacunata and partial elimination of S. sialivarius, S.sanguis, S. mutans, S. mitis from the biota.
The objective of the research was to study changes in the gingiva in the examined patients.
Materials and Methods. Microbiological (bacteriological and mycotic) examination of gum mucus secretion in the patients with partial loss of teeth was performed. The control group consisted of 50 (23 men and 27 women) patients without any infectious and noncommunicable diseases, who had no problems adapting to removable denture during the last 6 months.
Results and Discussion. In 78.72% of the patients, microorganisms isolated and identified from the surface of the prosthetic bed, were in associations that consisted of 2 (31.70%), 3 (8.51%) and 4 (8.51 %) taxons. The most numerous associations consisting of 2 taxons were: S. aureus and M. lacunata; S. aureus and N. flavescens; S. haemolyticus and B.catarrhalis as well as C. albicans and S. epidermidis. In the biotope (the surface of the gum mucosa of the prosthetic bed) of the patients wearing partial removable laminar dentures, the population level reduced in S. salivarius, S. sanguis, S. mutans, S. mitis and significantly increased in opportunistic staphylococci (S. aureus, S. haemolyties, S. epidermidis), S. pyogenes, enterobacteria (E. coli, K. pneumoniae, E. clocacae), B.catarrhalis. Microorganisms S. aureus and C. albicans reached a high population level; it increased in S. haemoliticus, S. epidermidis, S. pyogenes, E. coli, E. cloacae, K. pneumoniae as well.
Conclusions. In the patients with partial loss of teeth wearing conventional removable dentures, the taxonomic composition of the gingiva microbiota changed due to the contamination of the habitat with opportunistic S. aureus and yeast-like fungi of the Candida genus, S. haemolyticus, K. pneumoniae, enterobacteria (E .coli, K. pneumoniae, E. cloacae), B. catarralis, M. lacunata and partial elimination of S. sialivarius, S.sanguis, S. mutans, S. mitis from the biota.
Empirical Research on Acceptance of Digital Technologies in Medicine Among Patients and Healthy Users: Questionnaire Study
Authors: Safi Sabur , Danzer Gerhard , Schmailzl Kurt JG 
Published: October 2019

Background
In recent years, interest in digital technologies such as electronic health, mobile health, telemedicine, big data, and health apps has been increasing in the health care sector. Acceptance and sustainability of these technologies play a considerable role for innovative health care apps.

Objective
This study aimed to identify the spread of and experience with new digital technologies in the medical sector in Germany.

Methods
We analyzed the acceptance of new health care technologies by applying the Technology Acceptance Model to data obtained in the German ePatient Survey 2018. This survey used standardized questionnaires to gain insight into the prevalence, impact, and development of digital health applications in a study sample of 9621 patients with acute and chronic conditions and healthy users. We extracted sociodemographic data and details on the different health app types used in Germany and conducted an evaluation based on the Technology Acceptance Model.

Results
The average age of the respondents was 59.7 years, with a standard deviation of 16 years. Digital health care apps were generally accepted, but differences were observed among age groups and genders of the respondents. Men were more likely to accept digital technologies, while women preferred coaching and consultation apps. Analysis of the user typology revealed that most users were patients (n=4041, 42%), followed by patients with acute conditions (n=3175, 33%), and healthy users (n=2405, 25%). The majority (n=6542, 68%) discovered coaching or medication apps themselves on the internet, while more than half of the users faced initial difficulties operating such apps. The time of use of the same app or program ranged from a few days (n=1607, 37%) and several months (n=1694, 39%) to ≥1 year (n=1042, 24%). Most respondents (n=6927, 72%) stated that they would like to receive customized health care apps from their physician.

Conclusions
The acceptance of digital technologies in the German health care sector varies depending on age and gender. The broad acceptance of medical digital apps could potentially improve individualized health care solutions and warrants governance.
Determination of luminance distribution under tropical sky conditions
Authors: Nguyen Thi Khanh Phuong  
Published: October 2019

Introduction. Natural illumination calculations depend on the sky luminance distribution. The most often used diagram of sky luminance in handbooks and guidelines is the luminance distribution in the cloudy sky proposed by Moon and Spencer. This concept actually includes the tropical areas of Vietnam, where the overcast sky and clear sky does not typically occur. To improve the calculation of natural illumination, it is necessary to determine the luminance distribution in the real sky.
Materials and methods. In solving the research problem, the real sky types for Hanoi were identified using the 15 international standard sky types with their descriptions by lighting climate, which is provided using the method by R. Kittler. The descriptions are derived from the data on diffuse horizontal illumination Dv, extraterrestrial horizontal illumination Ev and light turbidity coefficient Tv. For a specific sky type, the standard parameters were selected for calculating the luminance distribution of the real sky.
Results. The obtained results show that the typical sky type of Hanoi is the partly cloudy sky, no gradation towards zenith, with slight bleaching towards the Sun (type VI). The sky types from October to December are partly cloudy with the obscured Sun (type IX) and partly cloudy with the more luminant circumsolar area (type X). The study shows that the state of cloud coverage has a great influence on the level of diffuse horizontal illumination and luminance distribution under tropical sky conditions.
Conclusions. It is revealed that the typical sky type for Hanoi is neither overcast nor clear sky. A typical sky with statistic dominance of cirrus and stratus clouds under effect of high solar radiation of Vietnamese tropical climate gives a high level of diffuse horizontal illuminance. The results show that the difference in luminance distribution between the CIE standard overcast sky and Kittler’s intermediate sky can be resolved at the angles of sky point elevation above horizon γ is higher than 50° with the relative errors below 10 %. In other words, the luminance distribution β of the considered sky type is significant for a system of side natural illumination.
Design of reinforced concrete slabs subject to the construction joints
Authors: Deineko Andrei V. , Kurochkina Valentina A. , Yakovleva Irina Yu. , Starostin Aleksandr N. 
Published: October 2019

Introduction. When erecting monolithic reinforced concrete floor slabs, a necessity of construction joints arises. The construction joints are the areas of structural weakening. The construction practice shows that the compliance with the correct technology of the construction joint arrangement is not a sufficient condition to ensure the strength balance of reinforced concrete floor slabs. As a result, the stress-deformation state calculated on the assumption of the concrete slab solidity deviates from the actual state. The relevance of the task is determined by the fact that the conformity of design and actual characteristics of the in-situ reinforced concrete structures as a whole depends on the correct calculations of construction joints.
Materials and methods. The problem of implementing the construction joints in the monolithic floor slabs was considered by way of example of a residential building under construction. In the course of construction, pre-construction land surveys were carried out at the areas of the construction joint arrangement. Calculations of reinforced concrete structures using finite element method (FEM) were also performed.
Results. As a result of the study, the actual deflections of the floor slabs were measured at the areas of the construction joints and FEM calculations were made on the same floor slabs, both those erected at once and those erected in stages subject to the construction joints. The difference between the calculated and actual deflections is conditioned upon the inaccurate conformity between the mathematical model and the real reinforced concrete structure, its erection and maintenance conditions. It should be noted that the deflection of horizontal reinforced concrete structures is only one of the stress-deformation state parameters that can be measured better than the others. It is shown that if the deflection of a real reinforced concrete structure does not correspond with the design estimation, the other stress-deformation state parameters will differ from the design estimation as well.
Conclusions. The influence of joints can be taken into account in the scope of FEM computer-aided calculations with the explicit reproduction of the structure erection by pouring concrete, using engineering approach to the consideration of nonlinearity on the basis of the introducing reduction coefficients to the reinforced concrete effective modulus of elasticity. Solid composition modeling of reinforced concrete provides the best possibilities on taking all sorts of nonlinearity manifestations into consideration.
Stress-deformation state of compound reinforced concrete bars with high-strength reinforcement prone to long-term compression
Authors: Zarakovskaya Kristina I. , Zakharov Vladimir F. 
Published: October 2019

Introduction. Considering that reinforced concrete is the most common material in construction and reconstruction of buildings and facilities, research of work of high-strength reinforcement in reinforced concrete elements, including compressed columns, are still relevant at present. Analysis of compound-section columns with high-strength longitudinal reinforcement is of particular interest since the method of sectional build-up is widespread enough in the reconstruction of buildings and facilities. However, no information on the work of this kind of reinforced concrete structures under long-term compression was found either in foreign or domestic literature; this fact provides relevance and academic novelty of the study.
Materials and methods. The article provides the research of parameters of the strain-stress state of compound reinforced concrete bars with high-tensile reinforcement under long time compression employing the modern methods of mathematical simulation.
Results. The developed calculation method allows determining additional parameters of the strain-stress state of the compressed compound-section reinforced concrete bars considering the concrete creep deformations forming in time of the long-term compression. When comparing the analytical study results with authors’ experimental data and previous results of other researchers, an adequate degree of reliability of the developed calculation method was confirmed.
Conclusions. When applying the developed calculation method of stress-deformation state parameters for the compressed compound-section columns with high-strength longitudinal reinforcement, the study discovered that significant effort redistribution from concrete to high-strength reinforcement occurs under long-term compression. This fact was confirmed with the results of an experimental investigation on the resistance of the compound reinforced concrete bars with high-tensile reinforcement to the longtime compression.
Preparation of low-toxicity cast foamed phenolic plastics
Authors: Nguyen Viet Cong  , Sosnovskiy Nikolay Y. , Yanchuk Valentin P. , Smirnova Anastasia M. , Grigorieva Larisa S. 
Published: October 2019

Introduction. Gas-filled polymers are highly efficient building thermal insulation materials, and therefore, researching to develop technologies to create them is a promising task. Phenol-formaldehyde foamed plastic can be a high-potential material with many significant advantages. However, the high toxicity of the phenol and formaldehyde compounds it releases is a significant deterrent to its usage. Therefore, the purpose of this study was to search for ways to reduce the toxicity of foamed plastic. The research considered the method of using ferric chloride as a complexing agent that binds phenol, with simultaneous use of sodium hexafluorosilicate to reduce material consumption.
Materials and methods. The studies were carried out on phenol-formaldehyde resin FRV-1A (TU 6-05-1104-78 “Resin, phenol-formaldehyde, foaming, brand FRV-1A”) and curing agent VAG-3 (TU 6-55-1116-88 “Product VAG-3”). The number of free phenol monomers was determined through gas chromatography method following GOST 11235-2017 “Phenoloformaldehyde resins. Methods for determination of free phenol”. The tests were carried out using a Tsvet-4 chromatograph. Tests on determining the foaming rate were carried out according to TU 6-05-1104-78 “Resin, phenol-formaldehyde, foaming, brand FRV-1A”. The density of the samples was measured basing on the mass-to-volume ratio of the samples. Strength was determined using samples of size 50 × 50 × 50 mm mm at 10 % compression on a test press.
Results. The conducted studies showed a decrease in the content of free phenol monomers in samples modified with ferric chloride. The use of sodium hexafluorosilicate allows significantly reducing the density of the finished material and, consequently, reducing the toxicity of foamed phenolic plastic per material mass unit.
Conclusions. According to the obtained results, the most effective for detoxifying a cast foamed phenolic plastic is the use of ferric chloride in an amount of 2 % of the FRV-1A oligomer mass with the addition of 0.5 % of the sodium hexafluorosilicate mass. The use of this method for modifying phenol-formaldehyde resin foam in the future may make it possible to obtain a much safer material and expand its areas of application.