bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interplay of Statins, Clopidogrel, and Repaglinide: Unraveling the Nexus of Hypoglycemia and Myopathy in a Geriatric Type 2 Diabetes Patient: A Case Report
Authors: Samajdar Shambo S. , Mukherjee Shatavisa , Saboo Bansi , Chatterjee Nandini , Pal Jyotirmoy , Joshi Shashank 
Published: October 2024

Abstract

Background:
The management of cardiovascular diseases often includes the use of statins, which, while reducing cardiovascular risk, can interact with other medications leading to significant adverse effects. This case report explores the complex interactions between atorvastatin, clopidogrel, and repaglinide, which precipitated severe hypoglycemia and myopathy in a patient with multiple comorbidities.

Case Presentation:
We describe a 68-year-old female with a history of type 2 diabetes mellitus, hypertension, and ischemic heart disease, who developed severe hypoglycemia and myopathy following the adjustment of her statin therapy post-cardiac diagnosis. Her treatment regimen was modified to include an increased dose of atorvastatin and the introduction of clopidogrel, shortly after which she presented with hypoglycemia and symptoms of myopathy. Investigations revealed significantly elevated muscle injury markers and magnetic resonance imaging findings consistent with myositis.

Discussion:
The pharmacokinetic interactions between clopidogrel with repaglinide and repaglinide with atorvastatin exacerbated by the increased dose of atorvastatin, likely led to the observed clinical manifestations. This case highlights the critical need for careful monitoring of drug interactions, especially in patients with polypharmacy. Adjustments in drug dosages and consideration of alternative medications with fewer interaction risks are essential components of managing similar cases.

Conclusion:
This case underscores the importance of vigilant therapeutic management and individualized patient care in the context of complex drug regimens. Understanding and anticipating drug interactions can prevent significant adverse effects and improve patient outcomes in a population at high risk of polypharmacy complications.
Investigating the Prevalence of Undiagnosed Diabetes and Its Associated Factors Among Healthcare Workers: A Cross-sectional Study in South of Iran
Authors: Zamani Ali , Assadian Kasra , Masoumi Seyed Jalil , Dashtaki Nadia Mohammadi , Ardekani Fariba Moradi , Mansouriyekta Elahe , Mirahmadizadeh Alireza 
Published: October 2024

Abstract

Context:
Undiagnosed diabetes mellitus (DM) is a hidden aspect of the diabetes epidemic. Globally, over 50% of cases are estimated to be undiagnosed. Undiagnosed DM poses serious public health concerns due to increased risks of complications.

Aims:
This study aimed to investigate the prevalence and associated factors of undiagnosed diabetes among healthcare workers in southern Iran.

Settings and Design:
This cross-sectional study analyzed baseline data from the Shiraz University of Medical Sciences Employees Health Cohort Study, involving 5918 healthcare workers aged from 20 to 70 years.

Materials and Methods:
Participants completed questionnaires, underwent anthropometric measurements, and provided blood samples for clinical laboratory tests. Undiagnosed diabetes was defined as fasting plasma glucose ≥126 mg/dL in those without a previous diagnosis.

Statistical Analysis Used:
Univariate and multivariate logistic regression analyses were used to determine associated factors.

Results:
The prevalence of undiagnosed diabetes was 1.2%. Diagnosed diabetes had a prevalence of 3.1%. Together, undiagnosed cases accounted for 27.4% of total cases. Age (odds ratio [OR] = 1.09, 95% confidence interval [CI] [1.05–1.12]), male gender (OR = 1.67, 95% CI [1.01–2.74]), general obesity (OR = 3.64, 95% CI [2.45–5.91]), abdominal obesity (OR = 2.62, 95% CI [1.52–4.52]), hypertension (OR = 1.84, 95% CI [1.06–3.17]), and dyslipidemia were associated factors for undiagnosed diabetes.

Conclusions:
Although lower than national estimates, over one-quarter of diabetic cases among health workers remained undiagnosed, highlighting the need for improved screening, especially in high-risk groups. Expanding screening programs, raising health literacy, and increasing community access to preventive services are essential steps in addressing the public health issue of undiagnosed diabetes.
Perceived Barriers to Leisure-time Physical Activity among Individuals at Risk of Type 2 Diabetes in India
Authors: Thirunavukkarasu Sathish , Fil Farah El , Prokou Maria , Venkatachalam Aravind , Kumar Siya , Shifaly Fathimath , Oldenburg Brian 
Published: October 2024

Abstract

Background:
Research on barriers to physical activity among adults in India is limited, and even less is known about this issue among individuals at high risk of developing diabetes.

Objectives:
We aimed to identify the perceived barriers to leisure-time physical activity among individuals at risk of developing type 2 diabetes in an Indian population.

Materials and Methods:
This cross-sectional study utilized baseline data (collected in 2013) from 1007 participants enrolled in the Kerala Diabetes Prevention Program. These participants were randomly selected from 60 polling areas (electoral divisions) in the Trivandrum district of Kerala state. Standardized questionnaires were employed to collect information on socio-demographics, leisure-time physical activity levels, and perceived barriers to physical activity. Statistical analyses comprised chi-square and t tests.

Results:
More than three-fourths (79.6%) of participants reported being physically inactive during their leisure time, with females showing a higher prevalence (84.6%) than males (75.2%; P < 0.001). The most common perceived barriers for both males (52.4%) and females (51.0%) in participating in leisure-time physical activities were “other priorities,” such as time constraints, family obligations, and work commitments. Females were significantly more likely than males to cite “lack of exercise skills,” “lack of social support,” and “exercise is not important” as barriers to leisure-time physical activity (all P < 0.05).

Conclusion:
Our study shows concerning levels of physical inactivity during leisure time among participants, particularly among females. Furthermore, the findings underscore the critical need for implementing interventions specifically targeted at addressing gender-specific barriers to leisure-time physical activity.
The possible protective role of glucosamine versus zoledronic acid on osteopenic effect of pantoprazole in adult male albino rats
Authors: Hamad Mona G. , Haiba Doaa A. , Estfanous Remon S. , Ibrahim Sarah 
Published: October 2024

Background
Osteopenia is an asymptomatic condition till fragility fractures occur and may be linked to prolonged use of pantoprazole.

Aim
To determine osteopenic effect of long-term use of pantoprazole and study the possible protective role of glucosamine versus zoledronic acid on this effect in adult male albino rats.

Patient and methods
A total of 60 rats were divided equally into six groups; group I subdivided equally into IA received no treatment and IB received normal saline. Group II received glucosamine. Group III received zoledronic acid. Group IV received pantoprazole. Group V received pantoprazole and glucosamine. Group VI received pantoprazole and zoledronic acid. After 12 weeks, the left femurs were subjected to radiography and measured bone mineral density from the proximal end (neck). The right proximal ends of femurs were processed for histological, immunohistochemical, and scanning electron microscopic studies.

Results
Groups V and VI showed restoration of normal trabecular histology with a highly significant increase in trabecular thickness and a highly significant decrease in inter-trabecular spaces and mean area% of osteopontin compared with group IV. However, it seemed that group V had a more anabolic effect revealed by significant increase in bone mineral density, Z-score, and mean area% of osteocalcin compared with group VI.

Conclusion
Long-term use of pantoprazole led to osteopenia. Concomitant use of either glucosamine or zoledronic acid with pantoprazole reduced the severity of trabecular damage induced by pantoprazole. However, it seemed that glucosamine exerted a more anabolic effect than zoledronic acid.
Assessment of Lacto-N-tetraose (LNT) as a Novel Food for Use in Food and Food Supplements (RP2101)
Authors:   Food Standards Agency,   Food Standards Scotland
Published: October 2024

Chr. Hansen, Denmark (“the applicant”) submitted a novel food application for the authorisation of lacto-N-tetraose (LNT) as a novel food to each nation of Great Britain in September 2023. The novel food is intended to be used as a source of human identical milk oligosaccharide, LNT, and is manufactured by microbial fermentation using a genetically modified strain of Escherichia coli BL21 (DE3), and then refined to yield the purified powder. This new application is seeking to use the novel food within the following food categories: food for special medical purposes and food supplements for the general population including those for vulnerable groups (pregnant and breastfeeding women, and the elderly); food for infants and young children including infant formula and follow-on formula. Food supplements are not intended to be used if other foods with added LNT or breast milk are consumed the same day. This novel food had its application for authorisation assessed by the European Food Safety Authority (EFSA) which was published in March 2022. The Food Standards Agency (FSA) and Food Standards Scotland (FSS) have reviewed the information available, including the EFSA opinion, and confirmed that LNT is safe under the proposed conditions of use. The anticipated intake levels and proposed use in food and food supplements was not considered to be nutritionally disadvantageous. This safety assessment represents the opinion of the FSA and FSS.
«Прашал еси о неких, иже купят челядь»: о христианском отношении к рабам и слугам на Руси
Authors: П.И. Гайденко 
Published: November 2024

Канонические ответы митрополита Иоанна II — древнейший канонический памятник. Он уже давно привлекает внимание исследователей, однако за всю свою историю он не получал полного, насколько это позволяют возможности, комментария. Представленный вниманию читателей очерк — опыт комментария одного из правил этого канонического свода. 22 правило Канонических ответов посвящено проблеме продажи рабов-христиан иноверцам, «поганым». Предварительный анализ текста позволяет говорить о том, что на Руси при продаже рабов не ориентировались на законодательство Византии, как, например, это было при организации церковной жизни. Очевидно, что митрополит Иоанн крайне негативно относился к имевшей место практике. Однако при этом он не решался вмешаться в происходящее, оставив этот вопрос на волю духовников.
The canonical answers of Metropolitan John II are the oldest canonical monument. It has long attracted the attention of researchers, but throughout its history it has not received a full, as far as possible, commentary. The essay presented to the attention of readers is a commentary on one of the rules of this canonical code. Rule 22 of the Canonical Answers is devoted to the problem of the sale of Christian slaves to Gentiles, the “pagans.” A preliminary analysis of the text allows us to say that in Rus’, when selling slaves, they were not guided by the legislation of the Byzantine Empire, as, for example, it was when organizing Church life. It is obvious that Metropolitan John had an extremely negative attitude towards the practice that took place. However, he did not dare to intervene in what was happening, leaving this issue to the will of confessors.
К проблеме миссионерских переводов богослужебных текстов на языки коренных народов России до 1917 г.
Authors: К. Джункова 
Published: November 2024

В статье рассматривается проблема миссионерских переводов литургии св. Иоанна Златоуста в историческом контексте, обращается внимание на необходимость нового подхода к христианизации коренных народов империи в первой половине XIX в., после массового отпада от православия в регионе Поволжья. Переломным моментом является миссионерская программа Н. И. Ильминского, по которой были созданы переводы литургии на основе местных разговорных языков. Рассмотрены переводы богослужения на абхазский, алтайский, бурятский, карельский, коми, марийский, татарский, удмуртский, чувашский и якутский языки. Указывается, что именно перевод на карельский язык 1911 г. содержит большинство славянских заимствований. Хотя традиция христианской проповеди была во время СССР прервана, на сегодняшний день священнослужители некоторых регионов вновь обращаются с исправлениями к миссионерским переводам XIX–XX вв.
The article deals with Russian Orthodox missionary translations of the Liturgy of St. John Chrysostom into the languages of the indigenous nations of the Russian Empire in the historical context. Attention is paid to the phenomenon of apostasy from Orthodoxy in the Volga region, which required a new approach to the Christianisation of the indigenous peoples in the early-mid 19th century. The turning point was the missionary programme of N.I. Ilminsky, according to which translations of the liturgy were created based on spoken local languages. The missionary translations of the liturgy into Abkhazian, Altai, Buryat, Chuvash, Karelian, Komi, Mari, Tatar, Udmurt, and Yakut languages are considered. It is pointed out that the liturgical translation into Karelian (1911) contains the largest number of Slavic borrowings. Although the tradition of Christianisation was interrupted during the Soviet period, nowadays priests turn to the old missionary liturgical translations in some regions, making some linguistic revisions.
Церковно-правовые и пастырские аспекты указов 1981–1993 гг. архиепископа Вологодского и Великоустюжского Михаила (Мудьюгина; 1912–2000)
Authors: Н.А. Тарнакин 
Published: November 2024

В статье рассмотрены 17 указов 1981–1993 гг. архиепископа Михаила (Мудьюгина, 1912–2000), которые систематизированы по трем группам: 1) решения с каноническими прещениями; 2) решения со снятием или смягчением наказания, а также с назначением воспитательных мер; 3) содержащие различные аспекты церковного права. Проведен анализ указов с точки зрения Канонического корпуса Православной Церкви. Показано, что 1) архиепископ Михаил не ссылается на канонические правила; 2) судебные решения принимаются им только по внутреннему убеждению, без учета канонов и предусмотренных ими санкций; 3) корреляция между решениями архиепископа Михаила и временем их принятия не обнаружена. Отмечается особое значение, которое архиепископ Михаил придавал пастырскому воздействию на церковного правонарушителя. Делаются выводы, что судебная деятельность архиепископа Михаила: 1) является примером живого церковного правотворчества конца XX в.; 2) показывает реальную возможность разрешения проблематики, заявленной на Всероссийском Поместном Соборе 1917–1918 гг., а именно отделения суда от администрации. Статья написана на основе доклада, сделанного автором на IV Барсовских чтениях (С.‑ Петербургская Духовная Академия, 7 декабря 2020 г.).
The article deals with 17 decrees of 1981–1993 by Archbishop Michael (Mudyugin, 1912–2000). The author systematized the decrees into three groups: 1) decisions with canon sanctions; 2) decisions with removal or mitigation of punishment, as well as with the appointment of educational measures; 3) decrees containing various aspects of ecclesiastic law. The article analyzes the decrees from point of view of the Canonical Code of the Orthodox Church. The author concludes that 1) Archbishop Michael does not refer to Canonical rules; 2) he makes judicial decisions only on inner conviction, without taking into account the canons and the sanctions provided; 3) found no correlation between the decisions of Archbishop Michael and the time of their adoption. The article notes the special importance that Archbishop Michael attached to pastoral influence on a Church offender. Finally, the judicial activity of Archbishop Michael 1) is an example of living ecclesiastical law-making in late 20th century; 2) shows the real possibility of resolving the issues raised at the 1917–1918 Local Council of the Russian Orthodox Church, namely, the separation of ecclesiastic court from administration. The article is written based on the report made at the 4th Barsov Readings (St. Petersburg Theological Academy, December 7, 2020).
«Да не явимся неблагодарни Вышнему, аще пренебрежем исправление и чина Духовнаго…»: церковные реформы Петра Великого в контексте концепции абсолютизма
Authors: Г.В. Бежанидзе , А.Г. Фирсов 
Published: November 2024

Статья посвящена анализу церковных реформ императора Петра Великого с точки зрения представлений об абсолютизме монархий раннего Нового времени. Современная историография абсолютизма утверждает, что в европейской политической мысли XVI–ΧVII вв. суверенитет монарха понимался не как безусловный, а как ограниченный заповедями Божиими. Идейная основа синодальной реформы Петра вполне соответствовала подобной теории. В Духовном Регламенте образцом Духовной Коллегии, учреждаемый для решения духовных дел, назывался церковный Собор. Надзиравший за деятельностью Синода обер-прокурор не только не был его членом, но и не рассматривался как представитель императора. В петровскую эпоху процесс снижения роли Церкви в государственной жизни, конечно, ускорился, но само государство, по-прежнему, позиционировалось как христианское общество.
The article is devoted to the analysis of the Emperor Peter the Great’s church reforms from the point of view of the ideas of early modern period monarchies about the absolutism. The modern historiography of absolutism asserts that in the 16th–17th centuries European political thought the monarch’s sovereignty was understood not as unconditional, but as limited by God’s commandments. The ideological basis of Peter’s synodal reform was fully consistent with such a theory. In the Ecclesiastical Regulation, the Church Council was called the model of the Ecclesiastical Collegium, established to resolve church matters. The Chief Procurator who oversaw the activities of the Synod was neither its member, nor considered as a representative of the emperor. In Peter the Great’s era, the process of reducing the role of the Church in state life, of course, accelerated, but the state itself, as before, was positioned as a Christian society.
Митрополит Ленинградский и Новгородский Григорий (Чуков) в памяти современников
Authors: А.Н. Кашеваров 
Published: November 2024

Митрополит Григорий (Чуков, 1870–1955) — выдающийся деятель Русской Православной Церкви первой половины ХХ века, один из ближайших сподвижников патриархов Сергия (Страгородского) и Алексия I (Симанского). В новейшее время деятельность митрополита Григория вызывает большой интерес. Однако до сих пор недостаточно изученным остается весьма важный вопрос о восприятии современниками личности митрополита. Целью предлагаемой статьи является попытка изучить образ владыки, каким он сложился в представлении его современников, прежде всего тех из них, кто близко соприкасался в своей деятельности с митрополитом Григорием и тем самым восполнить отмеченный выше пробел в изучении его жизнедеятельности. Из опубликованных, но еще не ставших предметом специального изучения мемуаров о митрополите особый интерес представляют воспоминания хорошо знавших его — Николая Александровича Заболотского (1922–1999) и Александра Александровича Осипова (1911–1967). На основе их анализа автор приходит к выводу, что у современников вызывало восхищение — прежде всего, его деятельность по возрождению духовных школ города на Неве — академии и семинарии. Для учащихся духовных школ его личность выступала как реальный пример беззаветного служения Церкви и народу, образ строгого и в то же время справедливого пастыря. Мемуаристы неизменно приводили конкретные примеры его скромности и самоотдачи, заботы о нуждах преподавателей и студентов духовных школ, подчеркивали его глубину ума и очевидную мудрость.
Metropolitan Gregory (Chukov, 1870–1955) is an outstanding figure of the Russian Orthodox Church in early-mid 20th century, a close associate of Patriarchs Sergius (Stragorodsky) and Alexius I (Simansky). In recent times, the activities of Metropolitan Gregory have been of great interest. However, a very important question of the perception of the Metropolitan’s personality by his contemporaries remains insufficiently studied. The purpose of this article is an attempt to study the Metropolitan’s image as it developed in the minds of his contemporaries, primarily those of them who were in close contact with Metropolitan Gregory in their activities, and thereby to fill the gap noted above in the study of his life. Among the memoirs about the Metropolitan published, but not yet subject to a special study, of particular interest are the ones of those who knew him well — Nikolai Alexandrovich Zabolotsky (1922–1999) and Alexander Alexandrovich Osipov (1911–1967). Based on their analysis, the author comes to the conclusion that his contemporaries admired, first of all, his work on the revival of theological schools in the city on the Neva — the Academy and the Seminary. For students of theological schools, his personality was a real example of selfless service to the Church and the people, an image of a strict and at the same time fair pastor. Memoirists constantly cited specific examples of his modesty and dedication, concern for the needs of professors and students of theological schools, and emphasized his deep mind and evident wisdom.
А. И. Булгаков (1859–1907) как исследователь англиканства
Authors: М.С. Стецкевич 
Published: November 2024

В статье анализируется процесс изучения англиканства профессором Киевской Духовной Академии А. И. Булгаковым. Посвятив свою кандидатскую, а затем и магистерскую диссертации генезису и развитию методизма, Булгаков в дальнейшем обратился к рассмотрению современного ему англиканства. Он питал надежду на то, что под влиянием Оксфордского движения (трактарианства) Церковь Англии не просто сможет восстановить систему Древней Церкви, но и решительно двинется в направлении православия. Пользуясь весьма ограниченным кругом источников и преувеличивая про-православную ориентацию Оксфордского движения, Булгаков тем не менее сумел представить весьма полную картину эволюции англиканства в XIX в. Исследуя вопрос о законности англиканской иерархии, Булгаков был готов признать ее действительной в случае восстановления Церковью Англии древнецерковных канонов. Труды Булгакова заложили основы традиции изучения англиканства XIX в. в России, а некоторые из них не потеряли научного значения до сего дня.
The article analyzes the process of studying Anglicanism by the Kiev Theological Academy Professor A. I. Bulgakov. Having devoted his candidate’s and then his master’s thesis to the genesis and development of Methodism, Bulgakov later turned to the consideration of contemporary Anglicanism. He hoped that under the influence of the Oxford movement (Tractarianism), the Church of England would not only be able to restore the system of the Ancient Church, but would also move decisively in the direction of Orthodoxy. Using a very limited range of sources and exaggerating the pro-Orthodox orientation of the Oxford movement, Bulgakov nevertheless managed to present a very complete picture of the 19th century evolution of Anglicanism. Investigating the question of the Anglican hierarchy’s legitimacy, Bulgakov was ready to recognize it as valid in case the Church of England restored ancient Church canons. Bulgakov’s works laid the foundations of the tradition of studying the 19th century Anglicanism in Russia, and some of his works have not lost their scientific significance up to this day.