bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of IL-25, IL-33, and Thymic Stromal Lymphopoietin in Nasal Polyp Gland Duct Epithelium in Patients With Chronic Rhinosinusitis
Authors: Nagata Yoshiyuki , Maruoka Shuichiro , Gon Yasuhiro , Mizumura Kenji , Kishi Hiroyuki , Nomura Yasuyuki , Hikichi Mari , Hashimoto Shu , Oshima Takeshi 
Published: March 2019

Background Nasal polyps accompany eosinophilic chronic rhinosinusitis (ECRS). Cytokines, including interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) expressed in nasal mucosa have been implicated in polyp pathogenesis. We investigated the role of nasal polyp epithelium cytokine expression in eosinophilic infiltration in ECRS. Methods Tissues were collected from 39 patients undergoing nasal surgery. Cases were divided into 3 groups: control (CTR), non-ECRS (nECRS), and ECRS and were evaluated for IL-25, IL-33, and TSLP expression. Results Abundant eosinophilia was observed underneath the nasal mucosa and around the nasal ducts in polyps in ECRS and correlated positively with IL-33 protein expression. Conclusion Cytokine expression in nasal duct cells and eosinophilic infiltration around duct cells similar to those in the nasal mucosa occurred in the nasal epithelium of polyps, suggesting its role in inducing eosinophilic inflammation.
The evaluation of the efficacy and safety of non-invasive neurally adjusted ventilatory assist in combination with INtubation-SURfactant-Extubation technique for infants at 28 to 33 weeks of gestation with respiratory distress syndrome
Authors: Miyahara Jun , Sugiura Hiroshi , Ohki Shigeru 
Published: March 2019

Objectives: The aim of this study is to evaluate the efficacy and safety of non-invasive neurally adjusted ventilatory assist used after INtubation-SURfactant-Extubation in preterm infants with respiratory distress syndrome. Methods: We conducted a prospective observational study that included 15 inborn preterm infants at 28 (0/7) to 33 (6/7) weeks of gestation with respiratory distress syndrome in the period from April 2017 to October 2018. After INtubation-SURfactant-Extubation, infants underwent non-invasive neurally adjusted ventilatory assist. INtubation-SURfactant-Extubation failure was defined as follows: fraction of inspired oxygen requirement >0.4, respiratory acidosis, and severe apnea within 5 days after surfactant administration. Results: Two of the 15 (13.3%) infants showed INtubation-SURfactant-Extubation failure and required mechanical ventilation. No infants experienced any major complications such as pneumothorax, patent ductus arteriosus ligation, severe intraventricular hemorrhage, periventricular leukomalacia, retinopathy of prematurity, or death. Conclusion: The rate of INtubation-SURfactant-Extubation failure when non-invasive neurally adjusted ventilatory assist was used after INtubation-SURfactant-Extubation for preterm infants with respiratory distress syndrome was 13.3%. Non-invasive neurally adjusted ventilatory assist can be safely performed without severe complications for preterm infants soon after birth.
RETRACTED ARTICLE: Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145
Authors: Sui Hongyang , Lou Anfeng , Li Zhisong , Yang Jianjun 
Published: March 2019

Abstract
Background
Gastric cancer receives considerable attention not only because it is the most common cancer all through the world, but also because it’s on the top third leading reason for cancer-related death. Lidocaine is a well-documented local anesthetic that has been reported to suppress cancer development. The study explored the effects of lidocaine on the growth, migration and invasion of the gastric carcinoma cell line MKN45 and the mechanism behind.

Methods
The effect of lidocaine on viability, proliferation and apoptosis of MKN45 cells were analyzed by Cell Counting Kit-8 assay, BrdU staining assay and flow cytometry, respectively. Moreover, cell migration and invasion were both examined by Transwell assay. The expression of apoptosis-, migration-, and invasion-related proteins were detected by western blot. The relative expression of miR-145 was determined by qRT-PCR. Moreover, the impact which lidocaine brought on MEK/ERK and NF-κB pathways were examined by western blot.

Results
Lidocaine inhibited viability, proliferation, migration, and invasion of MKN45 cells, while enhanced apoptosis. Moreover, miR-145 expression was enhanced by lidocaine; and transfection with miR-145 inhibitor increased cell viability, proliferation, migration, and invasion, but inhibited apoptosis. The up-regulation of miR-145 was partly contributed to the inhibitory effect of lidocaine on gastric cancer cell line MKN45. Finally, lidocaine inactivated MEK/ERK and NF-κB pathways via up-regulation of miR-145.

Conclusions
Our results suggested that lidocaine decreased growth, migration and invasion of MKN45 cells via regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways.
Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals
Authors: Lu Hao , Anujan Priyanka , Zhou Feng , Zhang Yiliu , Chong Yan Ling , Bingle Colin D. , Roy Sudipto 
Published: March 2019

ABSTRACT
Motile cilia on multiciliated cells (MCCs) function in fluid clearance over epithelia. Studies with Xenopus embryos and individuals with the congenital respiratory disorder reduced generation of multiple motile cilia (RGMC), have implicated the nuclear protein MCIDAS (MCI), in the transcriptional regulation of MCC specification and differentiation. Recently, a paralogous protein, geminin coiled-coil domain containing (GMNC), was also shown to be required for MCC formation. Surprisingly, in contrast to the presently held view, we find that Mci mutant mice can specify MCC precursors. However, these precursors cannot produce multiple basal bodies, and mature into single ciliated cells. We identify an essential role for MCI in inducing deuterosome pathway components for the production of multiple basal bodies. Moreover, GMNC and MCI associate differentially with the cell-cycle regulators E2F4 and E2F5, which enables them to activate distinct sets of target genes (ciliary transcription factor genes versus basal body amplification genes). Our data establish a previously unrecognized two-step model for MCC development: GMNC functions in the initial step for MCC precursor specification. GMNC induces Mci expression that drives the second step of basal body production for multiciliation.
Serial ankle casts for patients with idiopathic toe walking: Effects on functional gait parameters
Authors: Thielemann F. , Rockstroh G. , Mehrholz J. , Druschel C. 
Published: March 2019

Purpose The aim of the present study was to investigate the functional effects on gait parameters of serial ankle casts for patients with idiopathic toe walking (ITW), in comparison with an unremarkable control group. Methods A prospective trial with a pre-test–post-test control group design included ten patients with ITW and ten healthy matched children. Children with ITW underwent serial casting to stretch the plantar flexors, with two 14-day periods with walking plaster casts set at the maximum available ankle dorsiflexion. Both groups were assessed clinically and using a functional gait analysis before and after serial casting, as well as at a six-month follow-up visit. Results The normalized plantar heel force increased from 5% pre-interventionally to 79% at the follow-up. The upper ankle-joint angle and the base angle also demonstrated significant changes. Normalized compound action potentials of the medial heads of the gastrocnemius were reduced by 70%. None of these parameters demonstrated any significant differences at the follow-up examination in comparison with the healthy control group. Variations in the displacement of the knee joint on the sagittal plane and of the center of gravity in the transverse plane did not show any significant differences in comparison with the control group. Conclusion The reduction of muscle tone and lengthening of the ankle plantar flexors led to persistent increased active ankle dorsiflexion with significant long-term improvement of functional kinematic parameters. No significant difference in the gait analysis was found between the ITW group and healthy children six months after treatment. Level of Evidence Level II - Therapeutic
BENEFÍCIOS DO DESEMPENHO DA MOTOPODA NO DESGALHAMENTO DA COLHEITA FLORESTAL
Authors: Leite Elton Da Silva , Guedes Ilvânio Luiz , Amaral Edvaldes José do 
Published: March 2019

A desgalha é de alta relevância na colheita florestal e necessita de estudos científicos para mensurar as opções de uso manual e semimecanizado. Objetivou-se com o presente trabalho avaliar o desempenho técnico e de custos na atividade de desgalhamento na colheita de eucalipto com a motopoda e machadinha. Os estudos de tempos e movimentos mostraram que a atividade de desgalhamento demandou maior tempo para a motopoda e a atividade de limpeza exigiu maior tempo para a machadinha. O custo de produção foi similar para a motopoda e a machadinha. A motopoda apresentou maior produtividade e melhor qualidade do trabalho, evidenciando benefícios no processamento de desgalhamento na colheita florestal.
THE EFFECT OF AWARENESS, SPEED OF TRANSACTIONS, SECURITY, PERCEIVED USEFULNESS WITH MEDIATION OF PERCEIVED EASE OF USE ON M-BANKING ADOPTIONS BRI MAKASSAR RAYA
Authors: Mentari Andi Dewi , Ilfitriah Aniek Maschudah 
Published: March 2019

Mobile banking is a banking facility that uses mobile communication tools such as mobile phones. Mobile banking services provide convenience for customers to perform banking transactions such as check balances, transfer between accounts and bill payments and know the history of transactions made by users. This study aims to analyze the influence of Awareness, Transaction Speed, Security, Perceived Usefulness with Perceived Ease of Use Media to Adoption of m-banking BRI Makassar Raya. The sample used in this research is customer of m-banking BRI customer in Makassar Raya. The number of samples used in the study were 100 respondents who distributed directly and using purposive sampling technique. Data analysis using smartPLS program (Partial Least Square) version 2.0. The result of the research shows that the awareness variable has negative effect not significant to BRI m-banking Adoption, Transaction Speed has a significant positive effect on BRI m-banking Adoption, Security has positive significant effect on BRI m-banking Adoption, Perceived Usefulness has no significant effect to m -banking BRI, Perceived Usefulness has a significant negative effect on Perceived Ease of Use and Perceived Ease of Use has a significant positive effect on m-banking Adoption
RISIKO USAHA, RENTABILITAS DAN PERMODALAN SEBAGAI VARIABEL ANTESEDEN KESEHATAN BANK BUKU 3 DAN BUKU 4 DI INDONESIA
Authors: Herizon Herizon , Merty Nelaini Ika 
Published: March 2019

Banking world is inseparable from the competition of services, service offerings but also bank’s health scores, so banks are required to maintain their health scores. The purpose of this reseach was to know significantion analyze form that ratio IPR, LDR, IRR, PDN, NPL, BOPO, FBIR, NIM, ROA, and CAR has significant influence to bank’s health scores use RBBR metods. Population that wear in this research is BUKU 3 and BUKU 4 bank in Indonesia. The sample were selected used purposive sampling technique. This reseach use secondary data and data collection methods used documentation method. The type of research conducted in this research is causal research is analyzed using multiple linear regression analysis. Based on the result of the calculation and analysis before the result of the research hypotesis that the IPR, LDR, IRR, PDN, NPL, BOPO, FBIR, NIM, ROA dan CAR have significant effect for soudness score on BUKU 3 and BUKU 4 bank. IPR, IRR, NPL, FBIR, ROA and CAR has a negative effect not significant, LDR, PDN, and NIM has a positive effect not significant, BOPO has a negative effect and significant. Of the ten variables studied BOPO has dominant influence that is equal 24,4 percent among ten other independent variables. Suggestions for bank sample in this research to maintain its operational risks, minimize operational costs and increase operating income so that the health score is increasing every year.
QIYĀS SEBAGAI SEBUAH METODE DALAM NAHWU
Authors: Ni’mah Umi Nurun 
Published: March 2019

Language is an inseparable reality in human culture. It develops as the human civilization does. According to the linguists, classical Arabic has at least five methods of language development. Those are (a) isytiqāq (derivasi), (b) majāz (alegori), (c) naht (abrivasi), (d) ta’rīb (loan) dan (e) qiyās. Qiyas is exclusively analyzed in this research because it is the most common method, which is used widely by the linguists through its al-simā’ stage. This paper finds the fact that qiyas method in Arabic linguistic traditions have evolved into the pre and post al Khalîl bin Ahmad al-Farāhidī period.
DIALEK-DIALEK BAHASA ARAB
Authors: Suaidi Suaidi 
Published: March 2019

In various Arabic literary works, especially the ones, which concern with Qoranic studies, it is argued that the Koran was recited in the dialect of Quraisy. All dialects of the Arabic language were renowned for their eloquence but the dialect of Quraisy was considered the most expressive and articulate, and thus over generations, it came to be known as the dialect of the Koran. Generally the dialects of classical Arabic can be classified into Hijaz, Syria, Iraq, Egypt, and Morocco. The variations on dialects are because of the following factors: first are the extrinsic factors, which consist of social, cultural, geographical, and political factors. Second are the intrinsic factors, which cover phonological, morphological, and syntactical factor. All of those factors have gone in the process of ibdāl, i’rab, binâ’, tashīh, ‘ilāl, itmām, naqs , etc.
KEPELOPORAN MAHMŪD TAYMŪR DALAM CERPEN ARAB MODERN
Authors: Tasnimah Tatik Maryatut 
Published: March 2019

Mahmud Taymur was one of the founders of the Egyptian realistic short story, also known as Syaikh al-Qisasah alQashīrah. Remaining productive over a long life Taymur wrote extensive literary criticism and was the author of short stories, novellas, and plays totaling a score of volumes. Most notable for his skill in characterization, he achieved a literary eminence shared by few other Arabs of his generation in Cairo in 1947, and individual stories by him gave and appeared widely in English and European Anthologies. Taymur’s early works were influenced by Chekhov and Maupassant. His short stories of the 1920s and 1930s portrayed various social strata in Egypt. Taymur’s prose is marked by humanism and psychological subtlety. In the late 1930s and in the 1940s his prose was influenced by symbolism but after the revolutionary coup of 1952, Taymur’s works were predominantly realistic.
MENENGOK SENI TEATER/DRAMA UMAT ISLAM DI INDONESIA
Authors: Kusumawati Aning Ayu 
Published: March 2019

Theatre has become a part of the Islamic world recently. Moslems become more familiar with Islamic theatre and film. Indonesian independence, as well as the western theatre, triggers the blooming of theatre. To see its development in this country, where Moslems is the majority, it is necessary to observe how the local group of theatre or drama making its changes in their appreciation, conception, interpretation, expression, and creation. The main paradigm of the art of Islamic theatre, as the part of Islamic culture, can be understood through a textual and contextual approach.
SEJARAH BALAGAH: ANTARA MA’RIFAH DAN SINĀ’AH
Authors: Huda Ibnu Samsul 
Published: March 2019

When the literary world enters the realm of scientific study, the arbitrariness and the infinity of expression, which is the main characteristic of literary work, should be evaluated based on an objective standard of science. Balagah, a literary theory born and developed in Arab, has also undergone a process of standardization of concepts and theories as other sciences. This paper describes the history of balagah from embryonic phase until it has been structured to be a science with a set of scientific theories. A historical approach is expected to be able to reveal historical facts related to the codification of balagah since the beginning of its existence until its latest development. The systematization and theorization of balagah had been done since there was a trend of translations of Greek philosophy into Arabic. The demand of scientific knowledge in Greek tradition greatly endorsed the theorizing of balagah. Standardization of the theory of balagah positively facilitates learners to understand the science of balagah and to have scientific accountability. However, the systematization of balagah has led this study to a static condition. In addition, the orientation of balagah is more in linguistic (syntax) area.Simak
MAKNA SIMBOLIK GENDHING PATALON DALAM PERSPEKTIF RELIGIUSITAS ISLAM
Authors: Purwadi Purwadi 
Published: March 2019

This research aims to describe gendhing patalon in Wayang (shadow puppet) Purwa related to the context of Islamic teachings. Hermeneutic method and theory are employed to explore this study object. Wayang Purwa is Javanese manifestation of collective reflection and contemplation, tafakur and tadzakur. Wayang Purwa, with its artistic values, has spiritual education or al-tarbiyah al-rabbaniyah and morality concepts or al-akhlaq al-karimah. The dalang (puppet master), wiyaga (gamelan musician) and waranggana (gamelan choir) believe this gendhing was created by Walisanga (the nine Islamic pioneers in Java). Dalang, with his central position in the show of Wayang Purwa ought to teach his audience to do righteous deeds or amal shalih. The sacred Gendhing patalon conveys a religious atmosphere, which gives mystical experiences to its audiences. By seeing the performance, the audience is expected to get the idea of the self essence - rasa jati or makrifat. It is called wikan sangkan paraning dumadi or ‘knowing the highest truth’. Wayang Purwa plays its role for young generation in moral education, character building, and national identity in this global era. Problems of life as well as the nation can be solved by local wisdom approach.
PENERJEMAHAN KALA BAHASA ARAB DALAM BAHASA INDONESIA
Authors: Supardi Supardi 
Published: March 2019

This article examines the translation of Arabic tenses expression into Indonesian. This library research employs a descriptive analysis method based on Catford’s theoretical translation framework. This study finds that, firstly, from the extension of translation perspective, the tense expression in Arabic can be translated fully into Indonesian, in which all of the Arabic tense expression has the Indonesian equivalence. Linguistically speaking, in certain cases the translation of Arabic verbs both mādī (perfect) and mudāri’ (imperfect) has to be added with an Indonesian temporal adverb. The auxiliary verb kāna, which usually combined with mudāri’ verb in Arabic past tense is translated into Indonesian adverb of time: “dulu”, “dahulu”, or “tadi”. Secondly, the expression of Arabic future tense, which constitutes mudāri’ verb, prefix “sa_” or particle “saufa,” is also translated into “akan”. The mādī (perfect) verb, which is used in the context of wishing, is translated into Indonesian equivalence verb - “semoga”. Thirdly, In translating Arabic into Indonesian, context (siyāq) comes into play, not all Arabic verbs denotes definite tense in a sentence
BAHASA ALAY: REFLEKSI SEBUAH BUDAYA
Authors: Gunawan Fahmi 
Published: March 2019

Language reflects human conceptualization, human interpretation of the world. This paper aims to observe the relationship between the alay language and the alay speaker’s conceptualization/interpretation of the world. The data are taken from the written verbal interactions of STAIN Kendari students, who are active on facebook. By using Sapir’s and Whorf’s hypothesis and qualitative descriptive method, it is found that the alay language has close relationship with the alay speaker’s conceptualization/interpretation of the world. alay language style of writing which is randomized, does not have a system, is always abbreviated, and is only known by certain people, reflects the culture of indiscipline, instant, and short-sightedness.
IMPLEMENTASI SCADA UNTUK MONITORING DAN CONTROLING SERTA KOORDINASI SISTEM PROTEKSI GARDU INDUK SISTEM 1,5 BREAKER PADA GARDU INDUK TEGANGAN EKSTRA TINGGI BERBASIS ARDUINO MEGA 2560 DENGAN TAMPILAN HMI
Authors: Gumelar B Muhammad Adi , Ariyanto Eko 
Published: March 2019

Muhammad Adi Gumelar B, Eko Ariyanto, SCADA is one tool that can monitor and control the system at the substation and can coordinate the protection system area when a disturbance occurs. SCADA monitors the device continuously. This paper is to understand Differential protection areas, CCP, Buspro, and CBF that work when there is interference, namely internal and external interference by applying SCADA as its coordination. 12V DC relay is used as PMT, ACS712 as CT, and Ethernet Shield as Modbus to connect Arduino Mega 2560 with SCADA. Arduino Mega 2560 functions as a controlling center of input and output. The input used is the ACS712 sensor as a detector of the current flowing in the circuit. The Arduino Mega 2560 output signal will be sent to SCADA using an Ethernet Shield and router. Status of substations 1.5 breakers can be monitored with HMI from anywhere by using the SCADA application. In the event of a disturbance, each ACS712 will start reading the current changes and will be processed by Arduino Mega 2560, so that it can determine the protection area that works and trip the relay, SCADA will automatically record disturbances and give an alarm to occur by turning on the protection LED and sounding buzzer alarm. Keywords: 1.5 Breaker, Substation, Protection, SCADA.ReferencesHimpunan Buku Pedoman Pemeliharaan Master Station Scada SKDIR 0520-3.K/DIR/2014 Master Station SCADA No. Dokumen: PDM/PGI/04:2014). Jakarta. PT. PLN (Persero).Nurpadmi.2011. Studi Tentang Modbus Protokol pada Sistem Kontrol. Jurnal Teknologi, Volume 1. Nomor2. Cepu: Pusat Pengembangan Sumber Daya Manusia Minyak dan Gas Bmi.Arduino & Genuino Products. Arduino MEGA 2560 & Genuino MEGA2560. https://www.arduino.cc/en/Main/arduinoBoardMega2560. Diakses tanggal 26 Juni 2017.