bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a transtheoretical model‐based WeChat health education programme on self‐management among haemodialysis patients: A longitudinal experimental intervention study
Authors: Ren Qingli , Lian Minling , Liu Yang , Thomas‐Hawkins Charlotte , Zhu Lixia , Shen Qu 
Published: August 2019

AbstractAimTo examine the effects of a transtheoretical model‐based WeChat health education programme on self‐management in haemodialysis patients in China.DesignA longitudinal experimental intervention study.MethodsPatients (N = 120) who underwent haemodialysis from December 2015–November 2017 were recruited and randomly allocated to either group 1 (who received a 3‐month WeChat health education immediately after randomization) or group 2 (who was combined with group 1 and received the same intervention at the 5th month after enrolment in the study). Self‐management, knowledge and self‐efficacy were assessed at baseline (T0), 3 months after enrolment in the study (T1), 21 months after enrolment in the study (T2).ResultsThere were significant group effects on self‐efficacy; time effects on partnership, self‐care, emotion management with total self‐management; interaction effects on problem‐solving and emotion management within total self‐management according to the two‐way repeated measures ANCOVA. Further between‐group comparisons indicated that patients in group 1 had better self‐management than those in group 2 at T1. Within‐group comparisons demonstrated that, compared with the baseline values, group 1 had significantly improved self‐management at T1; however, group 2 had improved self‐management at T2.ConclusionThe transtheoretical model‐based WeChat health education programme had a potentially positive effect on improving the self‐management of haemodialysis patients.ImpactSelf‐management is often difficult yet crucial for haemodialysis patients. This study indicated that the transtheoretical model‐based WeChat health education resulted in improved self‐management in haemodialysis patients and can be implemented in continuing care during the interdialysis period to improve self‐management in patients.Trial registration: ChiCTR1800018172.
Depolarization and repolarization parameters on ECG predict recurrence after atrial fibrillation ablation in patients with hypertrophic cardiomyopathy
Authors: Wen Song‐Nan , Zhu Hao‐Jie , Sun Peng‐Yu , Wu Kui , Liu Nian , Ruan Yan‐Fei , Bai Rong , Tang Ri‐Bo , Yu Rong‐Hui , Long De‐Yong , Sang Cai‐Hua , Jiang Chen‐Xi , Li Xin , Li Song‐Nan , Hu Rong , Du Xin , Dong Jian‐Zeng , Ma Chang‐Sheng 
Published: August 2019

AbstractIntroductionThe outcomes of atrial fibrillation (AF) ablation remain suboptimal. It is important to identify which AF patients will most likely benefit from ablation and who are more likely to show treatment failure, especially in those with structural heart disease such as hypertrophic cardiomyopathy (HCM).Methods and ResultsWe enrolled 120 HCM patients who underwent primary AF ablation (48 with persistent AF). Preprocedural QTc was measured and corrected using the Bazett's formula, and the distribution of fragmentation of the QRS complex (fQRS) was recorded. Arrhythmia recurrence was defined as any kind of documented atrial tachyarrhythmia of more than 30 seconds. Overall, arrhythmia recurrence occurred in 69 patients after 13.4 months’ follow‐up. fQRS was present in 71 (59.17%) patients and was most commonly (81.69%) observed in the inferior leads. QTc more than 448 ms could predict arrhythmia recurrence with a sensitivity of 68.1% and specificity of 68.6%. Patients with QTc more than 448 ms (hazard ratio [HR]: 1.982; 95% confidence interval [CI]: 1.155‐3.402; P = .013) or those with fQRS+ (HR: 1.922; 95% CI: 1.151‐3.210; P = .012) were at an increased risk of recurrence. A combination of fQRS+ and QTc more than 448 ms was superior to fQRS or QTc alone in predicting arrhythmia recurrence.ConclusionIn patients with HCM undergoing AF ablation, QTc prolongation, specifically >448 ms, and presence of fQRS are independent risk factors for arrhythmia recurrence at follow‐up. The combination of these two parameters has greater predictive value and would help to identify patients who are at the highest risk of procedural failure.
Ridge preservation in molar extraction sites with an open‐healing approach: A randomized controlled clinical trial
Authors: Lim Hyun‐Chang , Shin Hyun‐Seung , Cho In‐Woo , Koo Ki‐Tae , Park Jung‐Chul 
Published: August 2019

AbstractAimTo determine the effect of alveolar ridge preservation (ARP) in molar sites without primary flap closure.Materials and MethodsThree groups were established: extraction sockets grafted with deproteinized bovine bone mineral containing 10% collagen (DBBM‐C) and covered by a native bilayer collagen membrane (NBCM) (test group 1), sockets grafted with DBBM‐C only (test group 2), and sockets that healed naturally (control group). Primary flap closure was not attempted. Conebeam computed tomography scans were obtained immediately and then 4 months after ARP. A biopsy was performed. The change of the marginal bone level was measured.ResultsThere was significantly less horizontal resorption in test group 1 than in the control group at levels 1 mm (−1.02 ± 0.88 [mean ± SD] vs. −4.44 ± 3.71 mm) and 3 mm (−0.31 ± 1.51 vs. −2.27 ± 1.15 mm) below the crest, and significantly less vertical reduction in the midcrestal area in test group 1 than in test group 2 (−0.25 ± 0.95 vs. −1.15 ± 1.63 mm) (p < .05). There were no significant differences between test groups in clinical and histomorphometric measurements. All groups exhibited stable marginal bone levels after 1 year of loading.ConclusionAlveolar ridge preservation without primary flap closure in molar areas was effective in minimizing ridge resorption and facilitated implant treatment.
Prediction of progression of chronic atrophic gastritis withHelicobacter pyloriand poor prognosis of gastric cancer by CYP3A4
Authors: Zhang Fan , Wang Furong , Chen Cong , Wang Tianyu , Hu Jike , Su Ruiliang , Li Xuemei , Gu Baohong , Tang Shaojun , Chen Hao , Li Yumin 
Published: August 2019

AbstractBackground and AimIt has been well documented thatHelicobacter pylori(H. pylori) infection is a risk factor for aggravating gastric mucosal atrophy. However, the exact molecular mechanism mediating this process is not fully elucidated. The purpose of this study was to identify biomarkers, which may predict the risk for progression of chronic atrophic gastritis (CAG) withH. pylori.MethodsGSE27411 was downloaded from the Gene Expression Omnibus. The differentially expressed genes (DEGs) betweenH. pylori‐infected samples without CAG andH. pylori‐infected CAG samples were analyzed. Gene Ontology and pathway enrichment analyses were performed, followed by protein–protein interaction network construction. We used immunohistochemistry analysis to identify DEGs in 20 chronic gastritis, 20 CAG, and 22 gastric cancer (GC) specimens.ResultsA total of 303 upregulated and 26 downregulated DEGs were identified. The pathways enriched by upregulated DEGs were mainly related to fat digestion and absorption, peroxisome proliferator‐activated receptor signaling pathway, and chemical carcinogenesis. Cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) had the highest degrees in protein–protein interaction network. Moreover, the positive rates of CYP3A4 protein expression in chronic gastritis, CAG, and GC were 10% (2/20), 55% (11/20), and 77.3% (17/22), respectively (P < 0.001). The Kaplan–Meier analysis revealed that elevated expression of CYP3A4 was significantly associated with worse overall survival and first progression, respectively (P < 0.0001).ConclusionAccording to the findings of this study, the expression of CYP3A4 might be related to the potential carcinogenic transformation of CAG to GC. Therefore, CYP3A4 may be biomarkers to predict progression of CAG and poor prognosis of gastric cancer.
Does APC/CCDH1 control the human brain size?
Authors: Dohrn Maike F. , Bolaños Juan P. 
Published: August 2019

AbstractThis editorial highlights a study by Rodriguez, Sanchez‐Moran et al. (2019) in the current issue of the Journal of Neurochemistry, in which the authors describe a microcephalic boy carrying the novel heterozygous de novo missense mutation c.560A> G; p.Asp187Gly in Cdh1/Fzr1 encoding the APC/C E3‐ubiquitin ligase cofactor CDH1. A functional characterization of mutant APC/CCDH1 confirms an aberrant division of neural progenitor cells, a condition known to determine the mouse brain cortex size. These data suggest that APC/CCDH1 may contribute to the regulation of the human brain size.
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Mesotherapy: Safety profile and management of complications
Authors: Plachouri Kerasia‐Maria , Georgiou Sophia 
Published: August 2019

AbstractBackgroundMesotherapy is a procedure that involves the injection of active substances into the dermis and subcutaneous tissue in order to treat several local medical and cosmetic conditions. Despite being considered as a relatively safe method, a series of adverse reactions can occur due to its wide application and lack of standardization processes.ObjectivesThe aim of this paper is to summarize all the mesotherapy‐related complications published so far, and to provide an insight into their management.Patient/MethodsArticles derived from the databases, PubMed, EMBASE, and SCOPUS, and published between 1992 and 2018, were analyzed for this review. The study was conducted according to the PRISMA guidelines.ResultsIn this literature, there is a number of case series and isolated case reports describing various side effects of different severities. The therapeutic management of these complications is—in most cases—individualized.ConclusionsLarger systematic studies are needed in order to adequately evaluate the safety profile of mesotherapy, and in order to determine standardized therapy parameters, so as to minimize the risk of potential adverse reactions.
Metabolic and regulatory insights from the experimental horizontal gene transfer of the aurofusarin and bikaverin gene clusters to Aspergillus nidulans
Authors: de Reus Elise , Nielsen Mikkel Rank , Frandsen Rasmus John Normand 
Published: August 2019

SummaryWe staged the transfer of the aurofusarin and bikaverin biosynthetic gene clusters (BGCs) to Aspergillus nidulans with the aim of gaining functional insights into dynamics immediately following a horizontal gene transfer (HGT) event. While the introduction of both BGCs resulted in the production of detectable pathway metabolites in A. nidulans, the transferred aurofusarin BGC formed dimeric shunt products instead of aurofusarin. This was linked to low transcription of the cluster activator and insufficient activity of tailoring enzymes, demonstrating how a shift of the pathway bottleneck after HGT can result in metabolic innovation. The transferred bikaverin BGC readily produced bikaverin, providing a model system for studying the conservation of regulatory responses to environmental cues. Conserved PacC‐mediated pH regulation of the bikaverin BGC was observed between original host Fusarium fujikuroi and A. nidulans. Contrary to strong nitrogen responses described in other hosts, the BGC appeared unresponsive to environmental nitrogen in A. nidulans. While F. fujikuroi and A. nidulans both form chlamydospore‐like structures when exposed to ralsolamycin, specific induction of the bikaverin BGC was not observed in A. nidulans. We propose that the presence of compatible cis‐regulatory elements in BGCs facilitates regulatory conservation after transfer, without which the chromosomal context would dictate expression.
Beyond balancing selection: frequent mitochondrial recombination contributes to high‐female frequencies in gynodioecious Lobelia siphilitica (Campanulaceae)
Authors: Adhikari Binaya , Caruso Christina M. , Case Andrea L. 
Published: August 2019

Summary

Gynodioecy is a sexual system in which females and hermaphrodites co‐occur. In most gynodioecious angiosperms, sex is determined by an interaction between mitochondrial male‐sterility genes (CMS) that arise via recombination and nuclear restorer alleles that evolve to suppress them. In theory, gynodioecy occurs when multiple CMS types are maintained at equilibrium frequencies by balancing selection. However, some gynodioecious populations contain very high frequencies of females. High female frequencies are not expected under balancing selection, but could be explained by the repeated introduction of novel CMS types.

To test for balancing selection and/or the repeated introduction of novel CMS, we characterised cytoplasmic haplotypes from 61 populations of Lobelia siphilitica that vary widely in female frequency.

We confirmed that mitotype diversity and female frequency were positively correlated across populations, consistent with balancing selection. However, while low‐female populations hosted mostly common mitotypes, high‐female populations and female plants hosted mostly rare, recombinant mitotypes likely to carry novel CMS types.

Our results suggest that balancing selection maintains established CMS types across this species, but extreme female frequencies result from frequent invasion by novel CMS types. We conclude that balancing selection alone cannot account for extreme population sex‐ratio variation within a gynodioecious species.
Effect of beta2‐adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men
Authors: Lemminger Anders Krogh , Jessen Søren , Habib Sajad , Onslev Johan , Xu Stella Feng Sheng , Backer Vibeke , Bangsbo Jens , Hostrup Morten 
Published: August 2019

While beta2‐adrenoceptor stimulation has been shown to increase lean mass and to alter metabolic properties of skeletal muscle, adaptations in muscle oxidative enzymes and maximal oxygen uptake (O2max) in response to beta2‐adrenergic agonist treatment are inadequately explored in humans, particularly in association with resistance training. Herein, we investigated beta2‐adrenergic‐induced changes in O2max, leg and arm composition, and muscle content of oxidative enzymes in response to treatment with the selective beta2‐adrenergic agonist terbutaline with and without concurrent resistance training in young men. Forty‐six subjects were randomized to 4 weeks of lifestyle maintenance (n = 23) or resistance training (n = 23). Within the lifestyle maintenance and resistance training group, subjects received daily terbutaline (8 × 0.5 mg) (n = 13) or placebo (n = 10) treatment. No apparent treatment by training interactions was observed during the study period. Terbutaline increased leg and arm lean mass with the intervention, whereas no treatment differences were observed in absolute O2max and incremental peak power output (iPPO). Treatment main effects were observed for O2‐reserve (P < .05), O2max relative to body mass (P < .05), O2max relative to leg lean mass (P < .01), and iPPO relative to leg lean mass, in which terbutaline had a negative effect compared with placebo. Furthermore, content of electron transport chain complex I‐V decreased by 11% (P < .05) for terbutaline compared with placebo. Accordingly, chronic treatment with the selective beta2‐adrenergic agonist terbutaline may negatively affect O2max and iPPO in relative terms, but not in absolute.
Workplace bullying and risk of burnout in nurses: a systematic review protocol
Authors: Purpora Christina , Cooper Adam , Sharifi Claire , Lieggi Michelle 
Published: August 2019

ABSTRACT

Objective:
The objective of this review is to assess the association between workplace bullying and nurse burnout.

Introduction:
Internationally, workplace bullying has been linked to nurse burnout. Burnout is of significant concern due to its association with nurses’ intent to quit, job dissatisfaction, reduced empathy and patient satisfaction. While there have been systematic reviews conducted on workplace bullying, none have explored its association with nurse burnout.

Inclusion criteria:
This review will consider studies that include licensed nurses in any clinical setting in any country. Only studies in which the Negative Acts Questionnaire-Revised was used to measure licensed nurses’ exposure to workplace bullying and in which the Maslach Burnout Inventory was used to measure burnout (i.e. the outcome of interest) will be considered. Prospective and retrospective cohort studies, case-control studies and analytical cross-sectional studies will be considered for inclusion.

Methods:
Key information sources to be searched for studies in English from 1990 to the present include CINAHL, Embase, PsycINFO, PubMed and Scopus. Two independent reviewers will screen titles, abstracts and full texts of selected citations against the inclusion criteria and appraise for methodological quality. Two reviewers will independently use the standardized data extraction tool to extract data from studies used in the review. Studies will, where possible, be pooled in a statistical meta-analysis. Where statistical pooling is not possible, the findings will be presented in narrative form including tables and figures to aid in data presentation, where appropriate.

Systematic review registration number:
PROSPERO CRD42019128798
Promoting informed consent in a children's hospital in Tabriz, Iran: a best practice implementation project
Authors: Kabiri Neda , Hajebrahimi Sakineh , Alizadeh Gisoo , Azimzadeh Solmaz , Farajzadeh Nayyereh , Talebpour Amin 
Published: August 2019

ABSTRACTIntroduction:Informed consent is a continuous and dynamic process. It is a crucial part of healthcare procedures that becomes more complex in a pediatric clinical practice, where parents must make decisions for their children.Objectives:The aim of this implementation project was to evaluate the current practice and implement the best practice related to obtaining informed consent in a children's hospital in Tabriz, Iran.Methods:A clinical audit was undertaken using the JBI Practical Application of Clinical Evidence System (JBI PACES) tool. Five audit criteria representing the best-practice recommendations for informed consent were used. A baseline audit was conducted, followed by the implementation of multiple strategies. The project was finalized with a follow-up audit to determine change in practice.Results:The compliance rate of all criteria improved from baseline to follow-up audit. Criteria 1 (obtaining informed consent prior to all nursing procedures) and 5 (provision of information related to the necessity of the treatment) reached 97% compliance in the follow-up cycle. Criterion 4 (provision of information related to the nature and effect of the treatment) achieved 74% compliance. Both criteria 2 and 3 (provision of information related to alternative treatments and consequences of refusing treatment) reached 57% in the follow-up cycle. To improve compliance, meetings were organized with the heads of departments, nurses and residents regarding informed consent. Also, staff were encouraged to report cases where informed consent was not obtained.Conclusion:The audit results indicated an improvement in obtaining informed consent in the included departments. The interventions that were employed can facilitate the implementation of evidence into clinical practice.
Unpacking the new AP Physics resources
Authors: Gende Dolores 
Published: August 2019

The College Board has released new curriculum resources for each of the four AP Physics courses: Course and Exam Description (CED) (Fig. 1)AP Classroom, a digital platform.
What follows is a summary of the most relevant elements of these new resources.
The Curriculum and Exam Descriptions are downloadable from AP Central,2 and teachers can order a free-of-charge hardcopy CED binder with a Course at a Glance poster. Each Course and Exam Description includes not only the curriculum framework, but also detailed unit guides and instructional strategies.
Diagnosis and treatment for hyperuricemia and gout: a systematic review of clinical practice guidelines and consensus statements
Authors: Li Qianrui , Li Xiaodan , Wang Jing , Liu Hongdie , Kwong Joey Sum-Wing , Chen Hao , Li Ling , Chung Sheng-Chia , Shah Anoop , Chen Yaolong , An Zhenmei , Sun Xin , Hemingway Harry , Tian Haoming , Li Sheyu 
Published: August 2019

ObjectivesDespite the publication of hundreds of trials on gout and hyperuricemia, management of these conditions remains suboptimal. We aimed to assess the quality and consistency of guidance documents for gout and hyperuricemia.DesignSystematic review and quality assessment using the appraisal of guidelines for research and evaluation (AGREE) II methodology.Data sourcesPubMed and EMBASE (27 October 2016), two Chinese academic databases, eight guideline databases, and Google and Google scholar (July 2017).Eligibility criteriaWe included the latest version of international and national/regional clinical practice guidelines and consensus statements for diagnosis and/or treatment of hyperuricemia and gout, published in English or Chinese.Data extraction and synthesisTwo reviewers independently screened searched items and extracted data. Four reviewers independently scored documents using AGREE II. Recommendations from all documents were tabulated and visualised in a coloured grid.ResultsTwenty-four guidance documents (16 clinical practice guidelines and 8 consensus statements) published between 2003 and 2017 were included. Included documents performed well in the domains of scope and purpose (median 85.4%, range 66.7%–100.0%) and clarity of presentation (median 79.2%, range 48.6%–98.6%), but unsatisfactory in applicability (median 10.9%, range 0.0%–66.7%) and editorial independence (median 28.1%, range 0.0%–83.3%). The 2017 British Society of Rheumatology guideline received the highest scores. Recommendations were concordant on the target serum uric acid level for long-term control, on some indications for urate-lowering therapy (ULT), and on the first-line drugs for ULT and for acute attack. Substantially inconsistent recommendations were provided for many items, especially for the timing of initiation of ULT and for treatment for asymptomatic hyperuricemia.ConclusionsMethodological quality needs improvement in guidance documents on gout and hyperuricemia. Evidence for certain clinical questions is lacking, despite numerous trials in this field. Promoting standard guidance development methods and synthesising high-quality clinical evidence are potential approaches to reduce recommendation inconsistencies.PROSPERO registration numberCRD42016046104.