bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical value of Naa10p and CEA levels in saliva and serum for diagnosis of oral squamous cell carcinoma
Authors: Zheng Jun , Sun Lichun , Yuan Wumei , Xu Jiang , Yu Xinle , Wang Fazhan , Sun Lisha , Zeng Yan 
Published: July 2018

BackgroundN‐α‐acetyltransferase 10 protein (Naa10p) is a potential prognostic biomarker that modulates the phenotypes of several cancer types. Carcinoembryonic antigen (CEA) is currently the most well‐known biomarker for the detection of epithelial malignancies. Our objective was to evaluate the clinical value of Naa10p, CEA, and their combined detection for diagnosis of oral squamous cell carcinoma (OSCC).MethodsThis study included 202 individuals: 112 patients with OSCC, 30 patients with oral premalignant lesions (OPMLs), and 60 cancer‐free and without OPML patients as control. Naa10p and CEA were determined in serum and saliva samples utilizing enzyme‐linked immunosorbent assays.ResultsSalivary and serum levels of Naa10p and CEA in OSCC patients were significantly higher than those detected in OPML and the control groups, although patients with OPMLs also showed increased salivary and serum Naa10p and CEA levels as compared to the control group. Salivary Naa10p level in OSCC patients is correlated with the degree of differentiation and lymph node metastasis, and serum Naa10p level is specifically correlated with patient age. Additionally, salivary CEA level is correlated with the clinical stage and lymph node metastasis, whereas serum CEA level is correlated with lymph node metastasis. The sensitivity, specificity, positive predictive value, and negative predictive value of combined detection were greater than any single detection.ConclusionsCombined use of salivary Naa10p and CEA as tumor markers for OSCC was more sensitive than serum Naa10p and CEA. These results indicated that combined detection of salivary Naa10p and CEA improved diagnostic performance and early detection rate for OSCC.
Suitability of a Mobile Phone Colorimeter Application for Use as an Objective Aid when Matching Skin Color during the Fabrication of a Maxillofacial Prosthesis
Authors: Mulcare Daniel C. , Coward Trevor J. 
Published: July 2018

AbstractPurposeColor matching a facial prosthesis to human skin is very challenging. Colorimeters aid this process by adding objectivity to what is an otherwise subjective procedure. Mobile phone colorimeter applications offer a less expensive and widely available alternative to dedicated colorimeter devices for color measurement. There is a lack of evidence in the literature regarding the suitability of mobile phone colorimeter applications for the development of silicone shades for facial prosthetics. The purpose of this study is to determine the suitability of a mobile phone colorimeter application for matching natural skin colors during the fabrication of maxillofacial prostheses.Materials and MethodsTen pigmented maxillofacial silicone elastomer swatches were fabricated to mimic a range of human skin tones. Color measurements of these swatches were recorded using a test instrument—the mobile phone colorimeter application (RGB Colorimeter) and a reference instrument—the commercially available skin color measurement device e‐skin spectrocolorimeter. Comparisons in trueness and precision of the color measurements were made using previously described methods. Data analysis was performed on the recorded results for each of the parameters at three distances (25, 30, and 35 mm) of the test instrument from the target against both a black and a white background.ResultsThe trueness of the mobile phone colorimeter application relative to the colorimeter device varied depending on the distance from the target and the background color. The relative trueness of the color difference measurements fell just within the documented upper threshold of acceptable limits of color difference (∆E 3.0 – 4.4). The calculated precision of the CIE L*a*b* and ∆E measurements of the mobile phone colorimeter application was good, with the latter being well within the documented acceptable limits.ConclusionsA mobile phone colorimeter application would be a suitable aid in objectifying the process of color matching a silicone maxillofacial prosthesis. Further investigation into image calibration to improve trueness and the control of variables such as background noise, uniformity of illumination, and measuring distance is required.
Rectal administration of metronidazole with and without rectal evacuation prior to use in horses
Authors: Stein Freya , Gilliam Lyndi , Davis Jennifer , Taylor Jared 
Published: July 2018

AbstractIn a randomized crossover design study, 10 adult horses were administered crushed metronidazole tablets rectally at 20 mg/kg. Horses' rectums were either evacuated (E) or not evacuated (NE) of manure prior to the administration of the drug. Serum samples were taken over 24 hr and plasma concentrations were determined via high pressure liquid chromatography. At 15 min post‐administration, group E had a significantly higher plasma concentration (p = 0.027), but there were no concentration differences at any other time points. There was large variability in relative bioavailability in theNEgroup, with a median of 86.7%. Based on our results, there is no advantage to manually evacuating a horse's rectum prior to rectal administration of metronidazole. Further study at higher dosages as well as examination of clinical efficacy is warranted.
Female labor supply, fertility rebounds, and economic development
Authors: Yakita Akira 
Published: July 2018

AbstractWe show that a fertility rebound can occur as the female wage rate rises concomitantly with economic development. Under plausible conditions, capital accumulation raises the marginal product of labor and hence the female wage rate. Unless the economy is trapped in a lower equilibrium, the fertility rate starts to decline at a certain level of the female wage rate and then turns upward at a higher wage level, presenting a fertility rebound. For such fertility rebounds to appear without policy intervention, the availability of external child care at high female wage rates is crucially important. The external child‐care price must be lower at high female wage rates. Otherwise the fertility rate might continue to decline.
Modesty can promote trust: Evidence from China
Authors: Ma Fengling , Heyman Gail D. , Xiao Li , Xu Fen , Compton Brian J. , Lee Kang 
Published: July 2018

AbstractWhen people let others know about their accomplishments, they can improve their social standing, but doing so may also have a cost, especially within social environments in which there is great emphasis on the value of modesty. One particular downside of self‐promotion, the risk of being seen as untrustworthy, was examined among children in China. Across three studies, children ranging in age from 7 to 11 years (total N = 251) judged the trustworthiness of protagonists who exhibited either modesty or immodesty. In Study 1, protagonists who told lies in the service of modesty were judged as more trustworthy than those who told lies to avoid getting into trouble. In Study 2, protagonists who demonstrated modesty were rated as trustworthy, but those who demonstrated immodesty were not. Study 3 showed that the positive implications of modesty for trust are specific to downplaying one’s own accomplishments and do not extend to downplaying the accomplishments of a peer. Taken together, the results suggest that for children in China, the level of modesty serves as a cue about which people can be trusted.
Role
of Heating Location on the Performance of a Natural Convection Driven Melting Process Inside a
Square-Shaped Thermal Energy Storage System
Authors: Satbhai Ojas , Roy Subhransu , Ghosh Sudipto 
Published: July 2018

Abstract
In this work, numerical experiments were performed to compare the heat transfer and thermodynamic performance of melting process inside the square-shaped thermal energy storage system with three different heating configurations: an isothermal heating from left side-wall or bottom-wall or top-wall and with three adiabatic walls. The hot wall is maintained at a temperature higher than the melting temperature of the phase change material (PCM), while all other walls are perfectly insulated. The transient numerical simulations were performed for melting Gallium (a low Prandtl number Pr = 0.0216, low Stefan number, Ste = 0.014, PCM with high latent heat to density ratio) at moderate Rayleigh number (Ra ≊ 105). The transient numerical simulations consist of solving coupled continuity, momentum, and energy equation in the unstructured formulation using the PISO algorithm. In this work, the fixed grid, a source-based enthalpy-porosity approach has been adopted. The heat transfer performance of the melting process was analyzed by studying the time evolution of global fluid fraction, Nusselt number at the hot wall, and volume-averaged normalized flow-kinetic-energy. The thermodynamic performance was analyzed by calculating the local volumetric entropy generation rates and absolute entropy generation considering both irreversibilities due to the finite temperature gradient and viscous dissipation. The bottom-heating configuration yielded the maximum Nusselt number but has a slightly higher total change in entropy generation compared to other heating configurations.
LNG Fuel: Experiences and Challenges — Addressing Tanks Under Accommodation and Bunkering
Authors: Teo Tony 
Published: July 2018

The presentation describes some of the challenges involved with the usage of LNG as a marine fuel. Today there are 37 vessels in operation in Norway and 35 of them have tanks under deck or accommodation. With the higher LNG Fuel investments for new-buildings, it makes good environmental and business sense to ensure that the vessels are additionally designed with energy efficiency, in line with IMO’s latest regulation towards CO2 reduction. In addition to the environmental benefit of using LNG, this gives further longer term economic benefits.
Various passenger Ro-Ro ferries with tanks under accommodation are described. In understanding how the tanks under accommodation and passenger areas are safely designed and accepted by IMO, the properties and the facts about LNG are illustrated to give a clear understanding on how the risks are relatively easy to mitigate and manage. Risk is a function of the likelihood of occurrence versus consequence. The mitigation methods in lowering the probability from occurrence are described. A look at the component in the LNG fuel propulsion system that is really critical and how this is mitigated is examined.
Another concern in the widespread use of small scale LNG is with the crew competence level related to LNG bunkering. The various methods of bunkering are described. Some developments towards safety and competence development in the industry are described.
The presentation concludes with some of the key elements included in the Crew Competence Standard.
Paper published with permission.
Post Macondo Safety and Regulatory Issues: Human Factors From an Organizational Development and Senior Management Perspective
Authors: Grossweiler Philip , Costello David , Graham Kevin 
Published: July 2018

Regulations governing the safety of drilling and offshore production operations have changed since the Macondo spill. This paper suggests management level perspectives on the nexus of human factors and safety management systems including an overview of ideas from: Congressional Testimony; the Bipartisan Policy Center inputs to the Presidents Commission on the Spill; the National Academy of Engineering and National Research Council Deepwater Horizon Report, and workshops and initiatives by RPSEA (Research Partnership to Secure Energy for America), SPE, and ASME. The value of benchmarks from risk management practices from the aviation, nuclear power, and financial community are also discussed. The paper will also consider questions as to what management might consider reducing risk and treating risk management as not just a cost center, but as a way to integrate safety management systems into improving corporate performance for all stakeholders.
Paper published with permission.
Experiences From Seven Years of DP Software Testing
Authors: Pivano Luca , Smogeli Øyvind 
Published: July 2018

This paper summarizes experiences from independent HIL testing of DP system software on more than 80 DP drilling, shuttle tanker, supply, anchor handling, construction and special purpose vessels. The paper includes examples of typical findings and a comprehensive analysis of finding statistics. The analysis shows how errors and weaknesses in core software and system configuration are distributed on the different functions in the DP system, as well as the potential consequence these errors could have had if they had not been identified and solved through early testing. The presented experiences demonstrate that independent testing of control systems using HIL testing technology is an important and effective service to ensure safe and reliable operation of offshore vessels.
Paper published with permission.
Association of Frailty and Long‐Term Survival in Patients Undergoing Coronary Artery Bypass Grafting
Authors: Tran Diem T. T. , Tu Jack V. , Dupuis Jean‐Yves , Bader Eddeen Anan , Sun Louise Y. 
Published: July 2018

Background
Frailty is increasing in prevalence and poses a formidable challenge for clinicians. The cardiac surgery literature consists primarily of small single‐center studies with limited follow‐up, and the epidemiological features of frailty remain to be elucidated in long‐term follow‐up.

Methods and Results
We conducted a population‐based, retrospective, cohort study in Ontario, Canada, between 2008 and 2015. Frailty was defined using the Johns Hopkins Adjusted Clinical Groups frailty indicator (a multidimensional instrument validated for research using administrative data). The primary outcome was mortality. Mortality rates were calculated using the Kaplan‐Meier method. The hazard of death was assessed using a multivariable Cox proportional hazard model. Of 40 083 patients, 8803 (22%) were frail. At 4±2 years of follow‐up, age‐ and sex‐standardized mortality rate per 1000 person‐years was higher in frail (33; 95% confidence interval, 29–36) compared with nonfrail (22; 95% confidence interval, 19–24) patients. Frailty was associated with an increased risk of long‐term mortality (adjusted hazard ratio, 1.20; 95% confidence interval, 1.12–1.28) and greater differences in the survival of patients between 40 and 74 years of age than in those who were ≥85 years old.

Conclusions
Frailty was present in a large proportion of patients undergoing coronary artery bypass grafting and was independently associated with long‐term mortality. The adjusted risk of frailty‐related death was inversely proportional to age. Our findings highlight the need for more comprehensive preoperative risk stratification models to assist with optimal selection of operative candidates. In addition, we identified the <75 years age group as a potential target for comprehensive preoperative optimization programs, such as cardiac prehabilitation, nutritional augmentation, and psychosocial support.
The concentration of total sialic acid in chronic hepatitis B and C
Authors: Gruszewska Ewa , Cylwik Bogdan , Gudowska Monika , Panasiuk Anatol , Flisiak Robert , Chrostek Lech 
Published: July 2018

Background The synthesis and glycosylation of glycoproteins and glycolipids take place in the liver. Thus, liver diseases may affect serum concentrations of some carbohydrate derivatives, especially the concentration of sialic acid which is attached to the end of oligosaccharide chains. The aim of this study was to measure and compare the serum concentration of total sialic acid in chronic hepatitis B and C. The hypothesis is that both viruses responsible for the development of inflammation work differently at the cellular level. Methods Serum samples were obtained from 90 patients suffering from liver diseases: 50 from chronic hepatitis B and 40 from chronic hepatitis C at the time of diagnosis. The total sialic acid concentration in the serum was measured according to the enzymatic method using a colorimetric procedure. Results The mean total sialic acid concentration in patients with chronic hepatitis B was significantly lower than the mean concentration in the healthy group, while in patients with chronic hepatitis C, it was significantly higher than that in healthy people and in patients suffering from chronic hepatitis B. There were no significant differences in total sialic acid concentrations in patients with chronic hepatitis B and C according to the grade of portal/periportal activity, the grade of lobular activity and the stage of fibrosis. Conclusions We conclude that chronic viral hepatitis affects the total serum concentration of sialic acid. Moreover, the concentration of total sialic acid may be a useful marker to differentiate between chronic hepatitis B and C but is not useful for evaluation of the progression of these diseases.
Protective effects of pentoxifylline in small intestine after ischemia–reperfusion
Authors: Eğin Seracettin , İlhan Mehmet , Bademler Süleyman , Gökçek Berk , Hot Semih , Ekmekçi Hakan , Ekmekçi Özlem Balcı , Tanrıverdi Gamze , Dağıstanlı Fatma Kaya , Kamalı Gülçin , Kamalı Sedat , Güloğlu Recep 
Published: July 2018

Objective This study was performed to determine the healing effects of pentoxifylline on molecular responses and protection against severe ischemic damage in the small intestine. Methods Thirty-six Wistar albino rats were divided into six groups. The superior mesenteric artery was clamped for 120 minutes, and reperfusion was performed for 60 minutes. Saline (0.4 mL), pentoxifylline (1 mg/kg), and pentoxifylline (10 mg/kg) were intraperitoneally administered to the rats in the C1, P1, and P3 groups, respectively, 60 minutes before ischemia and to the rats in the C2, P2, and P4 groups, respectively, during reperfusion onset. Malondialdehyde, myeloperoxidase, tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in serum and tissue were measured by enzyme-linked immunosorbent assay. Intestinal ischemic injury was histopathologically evaluated by the Chiu score and immunohistochemical staining. Results All serum and tissue molecular responses were significantly blunted in the pentoxifylline-treated groups compared with the controls. Significant improvement in ischemic damage was demonstrated in the pentoxifylline-treated groups by histological grading and immunohistochemical scoring. Conclusions The protective effects of pentoxifylline were confirmed by molecular responses and histopathological examination.
Serotonin Transporter Gene Polymorphism in Women With Suspected Ischemia
Authors: Park Ki , Egelund Eric , Huo Tianyao , Merz C. Noel Bairey , Handberg Eileen M. , Johnson B. Delia , Sopko George , Cooper-DeHoff Rhonda M. , Pepine Carl J. 
Published: July 2018

Introduction: Association of serotonin transporter gene ( 5-HTTLPR) polymorphisms with adverse cardiovascular (CV) events in women with suspected ischemia has not yet been reported. We hypothesized an association of 5-HTTLPR polymorphisms with risk of adverse CV events in women with suspected ischemic heart disease (IHD) referred for coronary angiography enrolled in the Women’s Ischemia Syndrome Evaluation (WISE). Method: We studied clinical and angiographic data and DNA from a cohort of 437 Caucasian women enrolled in the WISE genotyped for the long (L) and short (S) variant of the 5-HTTLPR polymorphism. Women were followed yearly for adverse CV events (defined as first occurrence of all-cause death, myocardial infarction, stroke, or heart failure hospitalization) with data collected at WISE 10-year follow-up. Exploratory analyses compared outcomes between genotype groups. Results: A total of 437 women, with baseline, angiographic, and long-term follow-up data, were successfully genotyped. Their mean age was 58 ± 11 years and body mass index 29 ± 6; 54% had hypertension, 18% diabetes, 50% dyslipidemia, 20% depression history, and only 34% had obstructive CAD. At 8.9 years median follow-up, the SS genotype was associated with significantly increased risk of adverse CV event versus LL + LS (1.93, confidence interval [CI]: 1.03-3.61, P = .03). Results were not significant for all-cause death (hazard ratio: 1.63, CI: 0.91-2.93, P = .09). Conclusion: Among a cohort of Caucasian women with suspected IHD enrolled in the WISE, the SS homozygous genotype for the 5-HTTLPR polymorphism was associated with increased risk of adverse CV outcomes.
Lenalidomide consolidation benefits patients with CLL receiving chemoimmunotherapy: results for CALGB 10404 (Alliance)
Authors: Byrd John C. , Ruppert Amy S. , Heerema Nyla A. , Halvorson Alese E. , Hoke Eva , Smith Mitchell R. , Godwin John E. , Couban Stephen , Fehniger Todd A. , Thirman Michael J. , Tallman Martin S. , Appelbaum Frederick R. , Stone Richard M. , Robinson Sue , Chang Julie E. , Mandrekar Sumithra J. , Larson Richard A. 
Published: July 2018

Key PointsBrief lenalidomide consolidation after chemoimmunotherapy is acceptably tolerated and extends PFS and OS in CLL. FCR has superior efficacy compared with FR chemoimmunotherapy for CLL.
Accurate recording of personality disorder in clinical practice
Authors: Tyrer Peter 
Published: July 2018

SummaryDisturbances of personality are recorded very poorly in official statistics, but there are signs that this is changing. For many years, personality disorder has been either regarded as a secondary diagnosis that can be forgotten in the presence of another mental disorder, or avoided as the diagnosis gives the impression of untreatability or stigma. What is now abundantly clear is that under-diagnosis of personality disorder represents a disservice to patients and practitioners. It prevents a proper understanding of the longitudinal course of psychiatric disorder and an appreciation of some of the positive aspects of abnormal personality that can be used in treatment. We must no longer bury personality disorder, ostrich-like, in the diagnostic sand. It is there for the asking and needs to be embraced honestly and without fear if we are to improve the management of psychiatric patients.Declaration of interestNone.