bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ex vivo indocyanine green fluorescence imaging for the detection of lymph node involvement in advanced‐stage ovarian cancer
Authors: Pop Catalin‐Florin , Veys Isabelle , Gomez Galdon Maria , Moreau Michel , Larsimont Denis , Donckier Vincent , Bourgeois Pierre , Liberale Gabriel 
Published: October 2018

Background and objectivesThe aim of this study was to evaluate the role of indocyanine green (ICG) fluorescence imaging (FI) for the ex vivo detection of metastatic lymph nodes (LNs) in advanced stage ovarian cancer (AOC).MethodsParaffin‐embedded LNs from patients included in a previous ICG‐FI study (Protocol NCT01834469) were further assessed for fluorescence. Intravenous injection of ICG was delivered intraoperatively. Tumor‐to‐background ratios (TBRs) were calculated.ResultsA total of 675 LNs from 19 patients were analyzed. The mean LN number per patient was 29.3 (median: 24; range 2‐77). Seventy‐three LNs were malignant (10.8%), 602 were benign (89.2%). The mean TBR of all LNs was 1.5 (SD 0.8). With a cut‐off TBR of 1.3, the sensitivity, specificity, positive predictive, and negative predictive values of ICG‐FI for retroperitoneal LNs were 80%, 41%, 2.8%, and 99%, respectively. On univariate analysis, only the fluorescence ratio (TBR ≥ 1.3) was correlated with malignancy at pathology (P = 0.03). No predictive factors of pathological LN status were found on multivariate analysis.ConclusionsEx vivo ICG‐FI of retroperitoneal LNs in AOC had good sensitivity but poor specificity. However, its high negative predictive value could make it an appropriate complementary tool to focus pathological analysis on fluorescent LNs.
Role of the general practitioner in the care of BRCA1 and BRCA2 mutation carriers: General practitioner and patient perspectives
Authors: Vande Perre Pierre , Toledano Daniel , Corsini Carole , Escriba Elsa , Laporte Marine , Bertet Helena , Yauy Kevin , Toledano Alain , Galibert Virginie , Baudry Karen , Clotet Lucie , Million Elodie , Picot Marie‐Christine , Geneviève David , Pujol Pascal 
Published: October 2018

AbstractBackgroundGeneral practitioners (GPs) have an increasing role in referring patients with putative mutation in BRCA1/2 genes for genetics consultation and for long‐term follow‐up of mutation carriers.MethodsWe compared the expectations of the GPs’ role according to BRCA1/2 mutation carriers and to GPs themselves.ResultsOverall, 38% (58/152) of eligible GPs and 70% (176/252) of eligible patients were surveyed. Although 81% of GPs collected the family history, only 24% considered that they know criteria indicating genetics consultation and 39% sufficient knowledge of BRCA1/2 guidelines to answer patients’ questions. Twelve% of GPs were aware of the French national guidelines. Among unsatisfied patients, 40% felt that their GP was able to answer (moderately, sufficiently, or completely) specific questions about BRCA1/2 care as compared with 81% in satisfied patients. Only 33% of GPs reported being informed directly by the geneticist about the patients’ results. GPs’ main expectations for their role in BRCA1/2 carrier care were psychological support and informing relatives about screening (72% and 71%, respectively), which contrasts with the perceptions of patients, who mainly requested medical advice for BRCA1/2‐related care (51%).ConclusionThere is an important need for GP training and enhancing interactions between GPs and geneticists to improve the GP's role in BRCA1/2 screening and management.
Contribution of next generation sequencing in pediatric practice in Lebanon. A Study on 213 cases
Authors: Nair Pratibha , Sabbagh Sandra , Mansour Hicham , Fawaz Ali , Hmaimess Ghassan , Noun Peter , Dagher Rawane , Megarbane Hala , Hana Sayeeda , Alame Saada , Lamaa Maher , Hasbini Dana , Farah Roula , Rajab Mariam , Stora Samantha , El‐Tourjuman Oulfat , Abou Jaoude Pauline , Chalouhi Gihad , Sayad Rony , Gillart Anne‐Celine , Al‐Ali Mahmoud , Delague Valerie , El‐Hayek Stephany , Mégarbané André 
Published: October 2018

AbstractBackgroundAccording to the Catalogue of Transmission Genetics in Arabs, less than half of diseases reported in Lebanese patients are mapped. In the recent years, Next Generation Sequencing (NGS) techniques have significantly improved clinical diagnosis, compared to traditional sequencing methods.MethodsA total of 213 analyses by NGS (167 by whole exome sequencing (WES) and 46 by multigene panels tests) were performed on pediatric patients across different regions of Lebanon over a period of two years (December 2015–December 2017).ResultsNeurological disorders were the most frequent referral demand for both WES and gene panels (122/213). Pathogenic, likely pathogenic, or variants of unknown significance were identified in 69.5% of the WES and panel patients combined. Over half of the patients with such variants had an autosomal recessive disorder. A definite molecular diagnosis (pathogenic or likely pathogenic variants) was achieved in 34.1% and 47.8% of the patients studied by WES and the multigene panels, respectively. Thirty‐three novel variants were found in the cases that were molecularly solved; 26 of these being identified by WES and seven by the multigene panels. In three consanguineous families, autosomal recessive inheritance of genes previously reported as showing dominant inheritance patterns were found. Biallelism was found in six cases, digenism in four cases, and one case was trigenic.ConclusionOur study thus suggests that NGS tools are valuable for an improved clinical diagnosis, and highlights that the increased adoption of such techniques will significantly further improve our understanding of the genetic basis of inherited diseases in Lebanon.
Reconfigurable antenna with multiple linear and circular polarization diversity for WLAN applications
Authors: Li Qiu Yu , Tran Huy Hung , Park Hyun Chang 
Published: October 2018

AbstractIn this paper, the principle and experimental validation of a multipolarization reconfigurable antenna is presented. The antenna is composed of four straight dipoles as radiating elements and six pairs of PIN diodes are used to adjust the antenna's polarization. By turning these PIN diodes on or off, the proposed design is able to realize linear polarization in horizontal, vertical, and two diagonal directions. In addition, dual‐sense circular polarization (CP) radiations are also achieved based on the method of using two orthogonal dipoles with different lengths. An antenna prototype is designed for wireless LAN applications and fabricated for validation. Measurements demonstrate that the proposed design achieves overlapped impedance and axial‐ratio bandwidths from 2.34 to 2.48 GHz and from 2.42 to 2.48 GHz, respectively. Measured broadside gains for all polarization states are from 6.2 to 6.7 dBi.
Technical Note: Clustering‐based motion compensation scheme for multishot diffusion tensor imaging
Authors: Xu Zhongbiao , Huang Feng , Wu Zhigang , Mei Yingjie , Jeong Ha‐kyu , Fang Wenxing , Chen Zhifeng , Wang Yishi , Dong Zijing , Guo Hua , Zhang Xinyuan , Chen Wufan , Feng Qianjin , Feng Yanqiu 
Published: October 2018

PurposeTo extend image reconstruction using image‐space sampling function (IRIS) to address large‐scale motion in multishot diffusion‐weighted imaging (DWI).MethodsA clustered IRIS (CIRIS) algorithm that would extend IRIS was proposed to correct for large‐scale motion. For DWI, CIRIS initially groups the shots into clusters without intracluster large‐scale motion and reconstructs each cluster by using IRIS. Then, CIRIS registers these cluster images and combines the registered images by using a weighted average to correct for voxel mismatch caused by intercluster large‐scale motion. For diffusion tensor imaging (DTI), CIRIS further reduces the effect of motion on diffusion directions by treating motion‐induced direction changes as additional diffusion directions. CIRIS also introduces the detection and rejection of motion‐corrupted data to avoid corresponding image degradation. The proposed method was evaluated by simulation and in vivo diffusion datasets.ResultsExperiments demonstrated that CIRIS can reduce motion‐induced blurring and artifacts in DWI and provide more accurate DTI estimations in the presence of large‐scale motion, compared with IRIS.ConclusionThe proposed method presents a novel approach to correct for large‐scale in‐plane motion for multishot DWI and is expected to benefit the practical application of high‐resolution diffusion imaging.
Unsupervised learning‐based flexible framework for surveillance planning with aerial vehicles
Authors: Faigl Jan , Váňa Petr , Pěnička Robert , Saska Martin 
Published: October 2018

AbstractThe herein studied problem is motivated by practical needs of our participation in the Mohamed Bin Zayed International Robotics Challenge (MBZIRC) 2017 in which a team of unmanned aerial vehicles (UAVs) is requested to collect objects in the given area as quickly as possible and score according to the rewards associated with the objects. The mission time is limited, and the most time‐consuming operation is the collection of the objects themselves. Therefore, we address the problem to quickly identify the most valuable objects as surveillance planning with curvature‐constrained trajectories. The problem is formulated as a multivehicle variant of the Dubins traveling salesman problem with neighborhoods (DTSPN). Based on the evaluation of existing approaches to the DTSPN, we propose to use unsupervised learning to find satisfiable solutions with low computational requirements. Moreover, the flexibility of unsupervised learning allows considering trajectory parametrization that better fits the motion constraints of the utilized hexacopters that are not limited by the minimal turning radius as the Dubins vehicle. We propose to use Bézier curves to exploit the maximal vehicle velocity and acceleration limits. Besides, we further generalize the proposed approach to 3D surveillance planning. We report on evaluation results of the developed algorithms and experimental verification of the planned trajectories using the real UAVs utilized in our participation in MBZIRC 2017.
Exploring the affective underpinnings of dynamic managerial capabilities: How managers' emotion regulation behaviors mobilize resources for their firms
Authors: Huy Quy , Zott Christoph 
Published: October 2018

Research SummaryOur inductive field study identifies specific emotion regulation (ER) actions as affective underpinnings of dynamic managerial capabilities. ER refers to the management and modification of one's own and other people's emotions for a specific purpose. Our study shows how differences in managers' attention to ER influence the extent to which they can mobilize resources to pursue market opportunities. We show how their ER of the self helps them mobilize human capital resources by creating psychic benefits, whereas their ER of others helps mobilize social capital by facilitating legitimacy judgments. Our emerging theory explains how the capacity for ER constitutes an important foundation of dynamic managerial capabilities and how it is linked with other key conceptual underpinnings of the construct, namely managerial human and social capital.
Managerial SummaryStrategic change processes can be full of ups and downs and have been likened to an emotional roller coaster. In this context, senior managers do not only to have to cope with their own emotions to deal with challenging situations; they also have to pay attention to the emotions of other stakeholders such as employees and investors to maintain or gain these stakeholders' support. Our field study identifies and explains the systematic behaviors that senior managers can use in strategic change contexts to regulate their own emotions as well as those of other stakeholders in order to productively address and overcome difficult business conditions.
Perfluorocarbon Nanoparticles Mediated Platelet Blocking Disrupt Vascular Barriers to Improve the Efficacy of Oxygen‐Sensitive Antitumor Drugs
Authors: Zhou Zaigang , Zhang Baoli , Wang Shushan , Zai Wenjing , Yuan Ahu , Hu Yiqiao , Wu Jinhui 
Published: October 2018

AbstractCurrently, limited tumor drug permeation and poor oxygen perfusion are two major bottlenecks that significantly impair the efficacy of existing antitumor drugs, especially oxygen‐sensitive antitumor drugs. One vital cause of these major bottlenecks is the abnormal tumor vessel barrier. To the best knowledge of the authors, platelets play a vital role in the maintenance of an abnormal tumor blood barrier through platelet–tumor interaction. Thus, platelet inhibition may present a new way to enhance drug delivery. In this study, it is originally discovered that perfluorotributylamine‐based albumin nanoparticles (PFTBA@HSA) possess excellent platelet inhibiting abilities, which then selectively disrupt the tumor vessel barrier, resulting in a remarkably enhanced intratumoral drug accumulation. Interestingly enough, the tumor hypoxia is also obviously relieved by enhanced oxygen carrier red blood cell distribution and PFTBA@HSA infiltration in the tumors. Finally, the efficacy of oxygen‐sensitive antitumor drugs is significantly amplified by PFTBA@HSA owing to enhanced drug permeation and relieved tumor hypoxia. Therefore, for the first time, it is demonstrated that PFTBA@HSA could be used as an effective way to improve the efficacy of existing tumor therapies by disrupting tumor vessel barriers through targeted platelet inhibition.
Enhanced Light–Matter Interactions in Self‐Assembled Plasmonic Nanoparticles on 2D Semiconductors
Authors: Luong Dinh Hoa , Lee Hyun Seok , Ghimire Ganesh , Lee Jubok , Kim Hyun , Yun Seok Joon , An Gwang Hwi , Lee Young Hee 
Published: October 2018

AbstractTwo‐dimensional (2D) transition‐metal dichalcogenide (TMD) monolayers of versatile material library are spotlighted for numerous unexplored research fields. While monolayer TMDs exhibit an efficient excitonic emission, the weak light absorption arising from their low dimensionality limits potential applications. To enhance the light–matter interactions of TMDs, while various plasmonic hybridization methods have been intensively studied, controlling plasmonic nanostructures via self‐assembly processes remains challenging. Herein, strong light–matter interactions are reported in plasmonic Ag nanoparticles (NPs) hybridized on TMDs via an aging‐based self‐assembly process at room temperature. This hybridization is implemented by transferring MoS2 monolayers grown via chemical vapor deposition onto thin‐spacer–covered Ag films. After a few weeks of aging in a vacuum desiccator, the Ag atoms in the heterolayered film diffuse to the MoS2 layers through a SiO2 spacer and self‐cluster onto MoS2 point defects, resulting in the formation of Ag‐NPs with an estimated diameter of ≈50 nm. The photoluminescence intensities for the Ag‐NP/MoS2 hybrids are enhanced up to 35‐fold compared with bare MoS2 owing to the local field enhancement near the plasmonic Ag‐NPs. The localized surface plasmon resonances modes of this hybrid are systematically investigated via numerical simulations and dark‐field scattering microscopy.
Conductive Molybdenum Sulfide for Efficient Electrocatalytic Hydrogen Evolution
Authors: Gao Xueqing , Qi Jing , Wan Shanhong , Zhang Wei , Wang Qiang , Cao Rui 
Published: October 2018

AbstractMolybdenum sulfide (MoS2) is a layered material with high activity for electrocatalytic hydrogen evolution reaction (HER). In conventional MoS2, the high electrical resistance between the layers hampers the bulk charge transfer and therefore greatly limits its performance in electrolysis. Herein, ultrathin MoS2 nanosheets with bent layers on reduced graphene oxide (RGO) are reported. In sharp contrast to the bulk MoS2, the resulting MoS2 has mostly 1 or 2 layers, and the layer distance is significantly expanded to ≈1 nm. From computational studies, the prepared MoS2 with limited layer numbers and expanded layer distances has similar physical and chemical features with single‐layer MoS2. Importantly, the bent single layer is electrically conductive and is intrinsically more active than a normal flat single layer. In addition, the unusual features of confined sizes and distorted lattices in the prepared MoS2 can bring about plentiful active sites and are beneficial for mass diffusion during electrocatalysis. The hybrid material exhibits high activity for electrocatalytic HER, affording a current density of 10 mA cm−2 at a low overpotential of 66 mV.
Heart toxicity from breast cancer radiotherapy
Authors: Piroth Marc D. , Baumann René , Budach Wilfried , Dunst Jürgen , Feyer Petra , Fietkau Rainer , Haase Wulf , Harms Wolfgang , Hehr Thomas , Krug David , Röser Arnd , Sedlmayer Felix , Souchon Rainer , Wenz Frederik , Sauer Rolf 
Published: October 2018

Abstract
Background
Late cardiac toxicities caused by (particularly left-sided) breast radiotherapy (RT) are now recognized as rare but relevant sequelae, which has prompted research on risk structure identification and definition of threshold doses to heart subvolumes. The aim of the present review was to critically discuss the clinical evidence on late cardiac reactions based on dose-dependent outcome reports for mean heart doses as well as doses to cardiac substructures.

Methods
A literature review was performed to examine clinical evidence on radiation-induced heart toxicities. Mean heart doses and doses to cardiac substructures were focused upon based on dose-dependent outcome reports. Furthermore, an overview of radiation techniques for heart protection is given and non-radiotherapeutic aspects of cardiotoxicity in the multimodal setting of breast cancer treatment are discussed.

Results
Based on available findings, the DEGRO breast cancer expert panel recommends the following constraints: mean heart dose <2.5 Gy; DmeanLV (mean dose left ventricle) < 3 Gy; V5LV (volume of LV receiving ≥5 Gy) < 17%; V23LV (volume of LV receiving ≥23 Gy) < 5%; DmeanLAD (mean dose left descending artery) < 10 Gy; V30LAD (volume of LAD receiving ≥30 Gy) < 2%; V40LAD (volume of LAD receiving ≥40 Gy) < 1%.

Conclusion
In addition to mean heart dose, breast cancer RT treatment planning should also include constraints for cardiac subvolumes such as LV and LAD. The given constraints serve as a clinicians’ aid for ensuring adequate heart protection. The individual decision between sufficient protection of cardiac structures versus optimal target volume coverage remains in the physician’s hand. The risk of breast cancer-specific mortality and a patient’s cardiac risk factors must be individually weighed up against the risk of radiation-induced cardiotoxicity.
3D Cf/SiBCN composites prepared by an improved polymer infiltration and pyrolysis
Authors: Ding Qi , Ni Dewei , Wang Zhen , Zhong Hao , Wang Hongda , Zhou Haijun , Kan Yanmei , Dong Shaoming 
Published: October 2018

Abstract
Using liquid poly(methylvinyl)borosilazanes (PMVBSZ) as precursor, carbon fiber reinforced SiBCN matrix composites (Cf/SiBCN) were fabricated by a modified polymer infiltration and pyrolysis (PIP) process. With dicumyl peroxide added as cross-linking agent, the PMVBSZ could be solidified at a low temperature of 120 °C, leading to a high ceramic yield of ~70%. The cross-linking mechanism and ceramization processes of the precursor were investigated in detail. Moreover, a modified infiltration technology was developed, which improved the efficiency and protected the precursor against moist air during PIP. Consequently, the obtained Cf/SiBCN composites had an oxygen content of around 1.22 wt%. Benefiting from the high ceramic yield and high efficiency of the modified PIP, Cf/SiBCN composites with an open porosity of ~10% and uniform microstructure were obtained after only 7 cycles of PIP. The flexural strength and fracture toughness of the derived Cf/SiBCN composites were 371 MPa and 12.9 MPa·m1/2, respectively. This work provides a potential route for the fabrication of high performance Cf/SiBCN composites.
Advanced prediction of functional outcomes in hip fracture patients using premorbid functional assessments
Authors: Hung Leong-Pan , Lam Hoi-Yee , Fung Wai-Ha , Samuel Ngan Kam-Tim , Yip Chiu-Tai , Fung Yim-Kwan 
Published: October 2018

Purpose: This historical cohort study aims to determine the relationship between premorbid functional status and functional decline in hip fracture patients. Methods: Eighty-two hip fracture patients were divided into Group A (good rehabilitation potential) and Group B (fair rehabilitation potential) based on four premorbid functional assessments: Modified Functional Ambulation Category (MFAC), Modified Barthel Index (MBI), Hong Kong Montreal Cognitive Assessment 5-Minute and functional prognosis predictive score. Declines in MFAC and MBI after rehabilitation were compared. Results: Sixty-seven percent of patients in Group A had up to one category decline in final MFAC, whereas 66% in Group B had more than one category decline. Similarly, median decline in final MBI was seven in Group A versus 22 in Group B. Conclusion: Hip fracture patients with good rehabilitation potential have significantly fewer functional declines. It is possible for them to be directly discharged from acute hospital for outpatient rehabilitation.
Sediment budget and morphological development of the Dutch Wadden Sea: impact of accelerated sea-level rise and subsidence until 2100
Authors: Wang Zheng Bing , Elias Edwin P.L. , van der Spek Ad J.F. , Lodder Quirijn J. 
Published: October 2018

AbstractThe Wadden Sea is a unique coastal wetland containing an uninterrupted stretch of tidal flats that span a distance of nearly 500km along the North Sea coast from the Netherlands to Denmark. The development of this system is under pressure of climate change and especially the associated acceleration in sea-level rise (SLR). Sustainable management of the system to ensure safety against flooding of the hinterland, to protect the environmental value and to optimise the economic activities in the area requires predictions of the future morphological development.The Dutch Wadden Sea has been accreting by importing sediment from the ebb-tidal deltas and the North Sea coasts of the barrier islands. The average accretion rate since 1926 has been higher than that of the local relative SLR. The large sediment imports are predominantly caused by the damming of the Zuiderzee and Lauwerszee rather than due to response to this rise in sea level. The intertidal flats in all tidal basins increased in height to compensate for SLR.The barrier islands, the ebb-tidal deltas and the tidal basins that comprise tidal channels and flats together form a sediment-sharing system. The residual sediment transport between a tidal basin and its ebb-tidal delta through the tidal inlet is influenced by different processes and mechanisms. In the Dutch Wadden Sea, residual flow, tidal asymmetry and dispersion are dominant. The interaction between tidal channels and tidal flats is governed by both tides and waves. The height of the tidal flats is the result of the balance between sand supply by the tide and resuspension by waves.At present, long-term modelling for evaluating the effects of accelerated SLR mainly relies on aggregated models. These models are used to evaluate the maximum rates of sediment import into the tidal basins in the Dutch Wadden Sea. These maximum rates are compared to the combined scenarios of SLR and extraction-induced subsidence, in order to explore the future state of the Dutch Wadden Sea.For the near future, up to 2030, the effect of accelerated SLR will be limited and hardly noticeable. Over the long term, by the year 2100, the effect depends on the SLR scenarios. According to the low-end scenario, there will be hardly any effect due to SLR until 2100, whereas according to the high-end scenario the effect will be noticeable already in 2050.