bluuebunny/crossref_metadata_2025_split huggingface dataset:
A snapshot of factual bitterness of elderly Indians: It’s time to act
Authors: Gupta Manoj Kumar , Raghav Pankaja , Gautam Vaishali , Choudhary Yachana , Ladha Nikhilesh 
Published: October 2019

Abstract
Background Elderly people suffer with diverse morbidities which comes with advancement in age. There is paucity of national and regional level studies to highlight the burden of various morbidities among elderly population in a comprehensive manner, which is of paramount importance for further fine tuning of policies and strategies for geriatric people in the country. The primary objective of the study was to screen the rural elderly people for major morbidity issues, and to find out their association with sociodemographic variables.Methods This community based study was conducted in rural area of Jodhpur, India. WHO’s 10-minute comprehensive screening tool was used for screening of geriatric giants. Other tools used were; SNELLEN chart, Dementia Assessment by Rapid Test (DART), Geriatric Depression Scale (GDS), weighing machine and stadiometer for calculating BMI, glucometer for random capillary blood sugar, and digital sphygmomanometer. Data was analyzed using SPSS v.23, and inferences were drawn using chi-square & t-test.Results Depression and dementia were found in 45.4% and 36.2% of elderly people, respectively. Age was a significant predictor for both. Functional disability in any form was prevalent among 73.7% people. Eighteen participants were either had history of falls for ≥2 times in past one year or were unsteady on examination. Nearly half were having impaired hearing and/or vision. As much as 44% of the elderly were either overweight or obese. More than one third of the participants were found hypertensive. One fourth were found with >140mg/dl random capillary blood sugar. Opium addiction was quite rampant in the study area (21.1%).Conclusions This study provides a comprehensive picture of regional level estimate of major geriatric morbidities in India. These findings reinforce the need to reform the healthcare delivery for elderly people in India, and rethink in the direction of improving their quality of life.
A Novel Prediction of Quaternary Structural Type of Proteins with Gene Ontology
Authors: Xiao Xuan , Chen Wei-Jie , Qiu Wang-Ren 
Published: October 2019

Background:
The information of quaternary structure attributes of proteins is very important
because it is closely related to the biological functions of proteins. With the rapid development
of new generation sequencing technology, we are facing a challenge: how to automatically
identify the four-level attributes of new polypeptide chains according to their sequence information
(i.e., whether they are formed as just as a monomer, or as a hetero-oligomer, or a homo-oligomer).

Objective:
In this article, our goal is to find a new way to represent protein sequences, thereby improving
the prediction rate of protein quaternary structure.

Methods:
In this article, we developed a prediction system for protein quaternary structural type in
which a protein sequence was expressed by combining the Pfam functional-domain and gene ontology.
turn protein features into digital sequences, and complete the prediction of quaternary structure
through specific machine learning algorithms and verification algorithm.

Results:
Our data set contains 5495 protein samples. Through the method provided in this paper,
we classify proteins into monomer, or as a hetero-oligomer, or a homo-oligomer, and the prediction
rate is 74.38%, which is 3.24% higher than that of previous studies. Through this new feature extraction
method, we can further classify the four-level structure of proteins, and the results are also
correspondingly improved.

Conclusion:
After the applying the new prediction system, compared with the previous results, we
have successfully improved the prediction rate. We have reason to believe that the feature extraction
method in this paper has better practicability and can be used as a reference for other protein
classification problems.
In silico Characterization of a Candidate Protein from Aphid Gelling Saliva with Potential for Aphid Control in Plants
Authors: Khan Rao Sohail Ahmad , Ali Zainab , Niazi Adnan Khan , Carolan James C. , Wilkinson Thomas L. 
Published: October 2019

Background:
Sheath or gelling saliva, secreted during feeding by aphids, is a hard material that
supports the piercing mouthparts and remains in the plant after feeding. Solidification or gelling of the saliva
might be due to the composition of amino acids in the constituent proteins, many of which probably interact
with plant defenses.

Objective :
The complete complement of proteins in the gelling saliva are still unknown, although one sheath
protein (SHP) has previously been identified as a potential candidate protein to control aphid feeding, but its
structure and its physiochemical role remains obscure. The current study provides structural information and
biochemical properties of the aphid sheath protein.

Methods:
The Sheath protein encoding gene was amplified from cDNA of the pea aphid (Acyrthosiphon pisum)
through PCR using specific gene primers. Sequence was in silico characterized by using EXPASY, Berkeley
Drosophila Genome Project (BDGP) Neural Network Promoter Prediction, BioEdit, Mega7, ProtParam, Phyre
server, 3D LigandSite SMART, MEME and GSDS programs, available online.

Results:
BLASTp analysis revealed that the sequenced gene was identical (100%) to the sequence from
Acyrthosiphon pisum, with 87% identity to Metpolophium dirhodum and 84% identity to Sitobion avenae.
Phylogenetically monocot feeders such as M. dirhodum and S. avenae are in a sister taxa to dicot feeders. In
silico analysis of the sequence revealed that sheath protein has a molecular weight of 144 kDa and 50% of the
protein is composed of only six amino acids, i.e., threonine, serine, aspartic acid, glutamic acid, isoleucine and
tyrosine. The computed IP value revealed that sheath protein is acidic in nature. Ligand binding sites for sheath
protein were predicted on residues 1123 and 1125 (isoleucine and glutamine, respectively). Metallic heterogens
are also present in sheath protein that are iron, zinc and magnesium, respectively.

Conclusion :
It is conceivable that variation in the salivary gene sequences may reveal important biological
information of relevance to the insect-plant interaction. Further exploration of insect salivary proteins, their
composition and structure will provide powerful information, especially when these proteins are interacting with
plant proteins, and specific information about the sheath protein, which is interacting with plants at a
molecular/cellular level, will be important to progress strategies aimed specifically against sucking pests such as
aphids.
Expression Level of MiRNA-126 in Serum Exosomes of Allergic Asthma Patients and Lung Tissues of Asthmatic Mice
Authors: Zhao Meizhen , Li Yu-Pei , Geng Xiao-Rui , Zhao Miao , Ma Shi-Bo , Yang Yu-Huang , Deng Zu-Hui , Luo Li-Mei , Pan Xin-Quan 
Published: October 2019

Background:
To investigate MiRNA-126 amounts in serum exosomes from allergic asthma patients as
well as lung tissues of asthmatic mice, evaluating the expression of its target gene DNMT1 in mouse specimens.

Methods:
MiRNA-126 amounts in serum exosomes from asthmatic patients were detected by real-time PCR. The
mouse model of allergic asthma was established by OVA-sensitization, and allergic symptoms were recorded; serum
IL-4 and sIgE level evaluation (ELISA), broncho alveolar lavage fluid (BALF) cell count and H&E staining were
performed to assess airway inflammation. MiRNA-126 and DNMT1 levels in the lung of asthmatic and control mice
were detected by real-time PCR; DNMT1 protein levels were detected by immunoblot.

Results:
MiRNA-126 amounts in peripheral blood exosomes from patients with allergic asthma were significantly
higher than that of healthy volunteers (P<0.05). The frequencies of scratching of both sides of the nose and sneezing
were elevated within 10 min of excitation in asthmatic rats compared with controls. Meanwhile, OVA-sIgE and IL-4
levels were significantly higher in asthmatic animals than controls (P<0.05). In the asthma group, narrowed bronchial
lumen and thickened wall were observed, and bronchial and peripheral vessels showed overt inflammatory cell infiltration.
Eosinophil, neutrophil and mast cell amounts in the BALF of asthmatic mice were significantly higher than
control values. Furthermore, lung miRNA-126 expression in asthmatic mice was significantly higher than that of
controls. Finally, DNMT1 mRNA and protein levels were significantly lower in asthmatic animals compared with
controls (P < 0.01).

Conclusion:
MiRNA-126 is highly expressed in serum exosomes from allergic asthma patients and lung tissues of
asthmatic mice, suggesting that it may be involved in the pathogenesis of bronchial asthma.
Actigraphy for Assessing Light Effects on Sleep and Circadian Activity Rhythm in Alzheimer's Dementia: A Narrative Review
Authors: Canazei Markus , Turiaux Julian , Huber Stefan E. , Marksteiner Josef , Papousek Ilona , Weiss Elisabeth M. 
Published: October 2019

Background:Alzheimer's Disease (AD) is often accompanied by severe sleep problems and circadian rhythm disturbances which may to some extent be attributed to a dysfunction in the biological clock. The 24-h light/dark cycle is the strongest Zeitgeber for the biological clock. People with AD, however, often live in environments with inappropriate photic Zeitgebers. Timed bright light exposure may help to consolidate sleep- and circadian rest/activity rhythm problems in AD, and may be a low-risk alternative to pharmacological treatment.Objective & Method:In the present review, experts from several research disciplines summarized the results of twenty-seven light intervention studies which used wrist actigraphy to measure sleep and circadian activity in AD patients.Results:Taken together, the findings remain inconclusive with regard to beneficial light effects. However, the considered studies varied substantially with respect to the utilized light intervention, study design, and usage of actigraphy. The paper provides a comprehensive critical discussion of these issues.Conclusion:Fusing knowledge across complementary research disciplines has the potential to critically advance our understanding of the biological input of light on health and may contribute to architectural lighting designs in hospitals, as well as our homes and work environments.
Pengaruh Kuat Arus Listrik Pengelasan Terhadap Kekerasan Lapisan Lasan pada Baja ASTM A316
Authors: Prayitno Dody , Hutagalung Harry Daniel , Aji Daisman P.B. 
Published: October 2019

Seat and plug are components of control valve that are always in friction contact. The plug usually wears out. One of the efforts in battling this wear is hardfacing, a process of cladding the base metal to increase its surface hardness using SMAW. This research is aimed to investigate the effect of welding current on weld surface hardness. The experiments used stainless steel (ASTM A316) for the plug materials and Stellite 6, which was an electrode with 3.2 mm in diameter, for the filler metal. Flat welding position was used. The current was varied from 120 A to 140 A and then to 160 A. Results of the hardness tests done on the weld surface show that when the welding current was increased from 120 A to 140 A, it increased the surface hardness from 465 HV to 514.7 HV. Subsequent current increase from 140 A to 160 A decreased the surface hardness from 514.7 HV to 423 HV.Sebuah control valve memiliki seat dan plug yang selalu bergesekan, sehingga plug sering mengalami keausan. Salah satu upaya untuk mengurangi keausan dengan cara hardfacing, yaitu penambahan material (cladding) pada logam induk dengan maksud meningkatkan kekerasan permukaan. Penambahan material dapat dilakukan dengan pengelasan SMAW, dimana salah satu parameter yang berpengaruh terhadap kekerasan lapisan lasan adalah besarnya arus listrik pengelasan. Tujuan penelitian adalah untuk mengetahui pengaruh arus listrik pengelasan terhadap kekerasan lapisan lasan. Metode penelitian dimulai dengan menyiapkan baja tahan karat (ASTM A316) digunakan sebagai material plug dan material stillite 6 sebagai material penambah yang berupa berupa elektroda berdiameter 3.2 mm. Pengelasan dengan posisi datar dengan variasi arus pengelasan adalah 120 A, 140 A dan 160 A. Hasil pengujian kekerasan menunjukkan bahwa peningkatan arus lasan dari 120 A ke 140 A meningkatkan kekerasan permukaan lasan dari 465 HV menjadi 514.7 HV. Peningkatan arus lasan berikutnya dari 140 A ke 160 A menyebabkan terjadinya penurunan kekerasan permukaan lasan dari 514.7 HV menjadi 423 HV.
Pengembangan Modul Elektronik Berbasis 3D Pageflip Professional Mata Kuliah Gambar Teknik di Program Studi Pendidikan Teknik Mesin
Authors: Nopriyanti Nopriyanti 
Published: October 2019

This study aims to: (1) develop an electronic module based on 3D Pageflip Professional for Engineering Drawings course, (2) assess the quality of the electronic modules. The model the research is research and development (R&D). The electronic module was validated by learning media experts and learning material experts. The research subject was the 32 students of mechanical engineering education study program of FKIP UNSRI. The study concludes that: (1) the electronic module that is based on 3D Pageflip Professional for Engineering Drawing Course is appropriate to use for learning process; (2) the quality of the product is very good. The assessment from the experts resulted in a score of 85 for the display aspect (very good), 51 for the learning process aspect (good), and 54 for the learning material aspect. Whereas, from the students, it is 956 (very good) for the display aspect, 684 for the learning process aspect, and 847 for the content aspect (very good)Penelitian ini bertujuan untuk: (1) menghasilkan Modul Elektronik Berbasis 3D Pageflip Professional pada mata kuliah Gambar Teknik di Program Studi Pendidikan Teknik Mesin, (2) mengetahui kualitas Modul Elektronik Berbasis 3D Pageflip Professional pada mata kuliah Gambar Teknik di Program Studi Pendidikan Teknik Mesin FKIP Unsri. Penelitian ini merupakan penelitian dan pengembangan (R&D). Validasi modul elektronik ini dilakukan oleh ahli media dan ahli materi. Subjek uji coba penelitian ini adalah 32 mahasiswa program studi pendidikan teknik mesin FKIP UNSRI. Hasil penelitian ini adalah: (1) produk modul Elektronik Berbasis 3D Pageflip Professional pada mata kuliah Gambar Teknik layak untuk digunakan; (2) Kualitas produk modul elektronik ini sangat baik, hasil penilaian ahli media dan ahli materi ditinjau dari aspek tampilan 85 (sangat baik), aspek pembelajaran 51 (baik), dan aspek materi 54 (baik). Sedangkan hasil penialaian peserta didik uji coba lapangan pada aspek tampilan sebesar 956 (sangat baik), pada aspek pembelajaran sebesar 684 (sangat baik), dan pada aspek isi sebesar 847 (sangat baik).
Studi Pemikiran Ibnu Qayyim Al-Jauziyyah tentang Ḥakam dan Relevansinya dengan Mediasi di Pengadilan Agama
Authors: Hasballah Khairuddin , Rahmadani Rahmadani 
Published: October 2019

Ulama berbeda pendapat tentang maksud ḥakam dan otoritasnya dalam ketentuan QS. An-Nisā’ ayat 35 terkait menyelesaikan perselisihan suami-istri. Masalah yang ingin diteliti adalah bagaimana makna ḥakam menurut Ibnu Qayyim al-Jauziyyah, bagaimana otoritas ḥakam dalam menyelesaikan sengketa suami-istri menurut Ibnu Qayyim al-Jauziyyah, dan bagaimana relevansi pemikiran Ibnu Qayyim al-Jauziyyah tentang ḥakam dengan mediasi di Pengadilan Agama. Hasil analisis menunjukkan bahwa makna ḥakam menurut Ibnu Qayyim al-Jauziyyah yaitu hakim. Maksud ḥakam bukan dimaknai sebagai wakil atau orang kepercayaan dari keluarga laki-laki atau perempuan. Ketentuan QS. An-Nisā’ ayat 35 menunjukkan makna yaitu dua orang ḥakam sebagai hakim yang menyelesaikan perselisihan masing-masing suami-istri. Otoritas ḥakam dalam menyelesaikan sengketa suami-istri menurut Ibnu Qayyim al-Jauziyyah yaitu diberi kewenangan untuk tetap menyatukan hubungan pernikahan suami-istri yang berselisih, atau bisa juga memutuskan dengan menceraikan keduanya. Terdapat bagian-bagian tertentu yang tampak sama dan relevan antara pemikiran Ibn Qayyim al-Jauziyyah tentang ḥakam dengan konsep mediasi di Pengadilan Agama. Kesamaan dan relevansi keduanya adalah terletak dari pihak yang menjadi juru damai, yaitu sama-sama ditentukan bukan dari pihak keluarga. Namun perbadaannya yaitu terkait dengan otoritas mediator dan ḥakam. Menurut Ibn Qayyim, ḥakam diberi kewenangan untuk memutuskan dengan menceraikan keduanya. Sementara dalam konsep mediasi, seorang mediator hanya bertugas mendamaikan dan tidak ada kewenangan untuk menceraikan.
Putusan Talak Raj’i pada Kasus Poliandri: Analisis Hukum Islam terhadap Putusan Hakim Mahkamah Syar’iyah Jantho Nomor 216/Pdt.G/2015/MS-JTH
Authors: Abbas Syahrizal , Mutia Datul 
Published: October 2019

Poliandri adalah sistem perkawinan dimana seorang wanita mempunyai suami lebih dari satu orang dalam waktu bersamaan. Al-qur’an dan Hadits melarang tindakan poliandri. Namun kenyataannya, ditemukan kasus poliandri di kalangan masyarakat. Hal ini dibuktikan dengan adanya cerai talak pada Mahkamah Syari’iyah Jantho dalam putusan Nomor 216/Pdt.G/2015/MS-JTH. Dalam perkara ini suami menceraikan isterinya karena melakukan poliandri. Penelitian ini bertujuan mengetahui dasar pertimbangan Hakim dalam memutus talak raj’i karena poliandri. Pada sisi lain, penelitian ini juga menggali pandangan hukum Islam dan hukum positif terhadap perkara talak raj’i karena poliandri. Penelitian ini menggunakan metode kualitatif dengan studi pustaka (library research). Hasil penelitian ini menemukan bahwa hakim menjatuhkan talak raj’i terhadap isteri yang melakukan poliandri di dasarkan pada larangan Al-quran dan Hadits tentang poliandri. Di samping itu, hakim juga mempertimbangkan kemaslahatan anak Pemohon dan Termohon yang masih dibawah umur yang sangat membutuhkan kasih sayang penuh dari kedua orangtuanya. Tindakan hakim ini sejalan dengan hukum positif dan hukum Islam. Untuk mengantisipasi munculnya praktek poliandri di masyarakat, di sarankan kepada pihak KUA dan tokoh agama agar memberikan pembinaan dan bimbingan perkawinan sehingga tidak terjadi pelanggaran hukum. Di sarankan juga kepada pemerintah untuk membuat regulasi yang dapat mencegah munculnya hukum poliandri dan mengatur hukuman kepada pelaku poliandri.
Economic Consequences of Corporate Governance Disclosure: Evidence from the 2006 SEC Regulation on Related-Party Transactions
Authors: Hope Ole-Kristian , Lu Haihao (Ross) 
Published: October 2019

ABSTRACT
This paper examines economic consequences of a 2006 Securities and Exchange Commission regulation that mandated public firms to disclose their governance policies on related-party transactions (RPTs). Employing hand-collected RPT data for S&P 1500 firms, we find that the initiation of RPT governance disclosure significantly reduces the occurrence of RPTs, and that the reduction in RPTs is negatively associated with the implied cost of capital (ICC) and positively related to Tobin's Q. These effects are more pronounced for low-monitored firms and for firms with RPTs that are more likely to be opportunistic. We further find that firms with a formal written policy, a designated committee to review and approve RPTs, or more extensive disclosure on RPT governance benefit in terms of lower ICC.
TRAINING RENOVASI DAN PERAWATAN POMPA HIDRAM DI DESA KARANG PELEM, KECAMATAN KEDAWUNG, SRAGEN
Authors: Sudjatmiko Aliem , Wiqoyah Qunik , Ujianto Mohammad 
Published: October 2019

Technological Pump the Hidram technology pump to use the basework style of grafitasi earth and designed in such a way till work the pumpwork automatically without there external energi for example energi oil.Constraint which often bother the [job/activity] pump the hidram is notoptimal is component function pump the effect stuffing up of dirt andcomponent damage pump. The pump Hidram equiped some kinds ofspillway, for example functioning water spillway to arrange awaking ofcurrent and awaking of pressure irrigate the , air-trap to arrange awakingof air composition in water. Especial benefit air good for condition of[isnature of water from nature of water which incompresible become semiincompresible so that punching influence irrigate the/hummer water notdestroy the material pump specially save the tekan.Tabung depress tofunction to catch and maintain the yielded water pressure. Component pumpthe hidram consisted of the Reservoir concentration, fast pipe, spillway oflimbah,balance weight, air spillway, spillway depress and save to depressand also other supporter that is pipe between. In course of evaluation[done/conducted] repair problem of water spillway using rubber of vehiclerut/rubber konveyor, and if/when reckoned from a economic side pumpthis very efficient because energi used to create the pressure irrigate tocome from laboring earth gravitation style air.Benefit from spillway irrigateand also air spillway can be arranged in such a way till work the pump canwork automatically and will labour on during balance constraint workthe pump not annoyed. From repair result got a technical age spillwaymount and stay more 6 month;moon and loss / water leakage causing tolessen the pressure can be avoided. To the condition of in such a way tillwork the pump automatically [done/conducted] a trial and error
ISOLASI MIKROROGANISME LOKAL PENGHASIL KARETONOID
Authors: Emantoko Sulistyo , Fransiscus Yunus , Sitepu Dewiana 
Published: October 2019

Caretonoid is the group of substances which have high economic value, because of their usefulness for the human being. This reason make exploration in the carotenoid field is very frequent. This is including exploration to find a new carotenoid source. Some common carotonoid sources such as algae and plant need sun light to produce carotenoid. This is become a restriction in carotonoid production. Now days, some researchers try to find microorganisms as carotenoid producer which is no need of sun light. The purpose of this research is to find microorganism which is produce carotenoid. In this research we isolate microorganism from the air and water pond using nutrient agar. After several screening we find to isolates which are isolate 2 and isolate 3. Isolate 2 can produce. 698,6 ng carotrene per 100 ml of culture and isolate 3 can produce 572,69 ng karoten per 100 ml of culture. About 898,01 μg astaxanthin can be produce per 100 ml of isolate 2 culture. Specific growth of isolate 2 and isolate 3 are 0,4138/our and 0,1292/our respectively.
Survey of Collaborative Data Mining
Authors: Anton Carmen Ana , Matei Oliviu , Avram Anca Diana 
Published: October 2019

Abstract
In the information industry there is a huge amount of data which can be used to obtain relevant information necessary for them to be processed, cleaned and analyzed. This survey paper presents different data extraction research that can be applied in various areas. The main point is to determine a new approach and to be the starting point for new experiments in agriculture predictions. The collaborative data mining approach assumes that correlated units or devices will have similar behavior that can be determined with an acceptable approximation.