bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building peace through mystic philosophy: study on the role of Sunan Kalijaga in Java
Authors: Waston Waston 
Published: December 2018

This paper aims to study the teachings of peace invented in the Javanese tradition particularly by Sunan Kalijaga. Sunan Kalijaga was a Muslim saint in the 15th century AD who taught mystical-philosophical teachings. His role permeates in the Javanese tradition so peaceful values that are embedded in its teachings still be traced and developed. We conducted a literature study on the role, influence and legacy of Sunan Kalijaga. We focused on his philosophical approach to religious thought as oppose to the mystical aspect. Our findings show that Sunan Kalijaga succeeded in using proper choice of words to combine Islamic values and predominant cultural elements (e.g., Hinduism, Buddhism). Therefore, instead of using the Arabic terms, Sunan Kalijaga used many old Javanese and Sanskrit terms commonly used in the 15th-16th century Javanese society. As an implication, Sunan Kalijaga created terms that are less Islamic but loaded with Islamic values. His examination is not only inherited into terms, but also practices, symbols and institutions. Among those Javanese traditions, some of them are critically important in supporting peace-building. This paper reaps the peaceful values of the Sunan teachings in the hope of countering the stream of extreme ideologies that have recently flooded the public. Paper ini bertujuan mengunduh ajaran damai yang ditanam dalam tradisi Jawaterutama yang disemai oleh Sunan Kalijaga. Sunan Kalijaga adalah seorang walipada abad ke 15 M yang memiliki ajaran bersifat mistis-filosofis. Hingga saat ini,pengaruh Sunan Kalijaga sangat terasa dalam tradisi Jawa sehingga nilai-nilaidamai yang ada dalam ajarannya masih dapat ditelusuri dan dikembangkan.Dengan menerapkan studi pustaka, data-data dalam riset ini dikumpulkan darisumber-sumber yang mengkaji Sunan Kalijaga, peran, pengaruh, dan warisanwarisannya.Oleh karena corak pemikiran keagamaan Sunan Kalijaga bersifatmistis-filosofis, maka aspek mistisisme dan pendekatan filsafat juga digunakandalam tulisan ini. Paper ini memaparkan temuan bahwa dalam pratiknya, SunanKalijaga melakukan permainan bahasa yang dengan cara tersebut ia berhasilmemadukan antara nilai-nila i keislaman dengan unsur buda y a dominanyang telah ada sebelumnya yaitu Hindu dan Buddha. Oleh karena itu, alihalihmenggunakan istilah Arab, Sunan Kalijaga justru banyak menggunakanistilah Jawa Kuna dan Sansekerta yang lazim digunakan dalam masyarakat Jawaabad 15-16. Hasil dari upaya tersebut, Sunan Kalijaga menghadirkan istilahistilahyang tampaknya kurang Islami namun sarat muatan nilai-nilai Islam.Ijtihad Sunan Kalijaga tidak hanya terwariskan menjadi istilah-istilah, namunjuga menjadi praktik, simbol bahkan melembaga. Dari beberapa bentuk tradisijawa yang diwariskan Sunan Kalijaga dapat diambil bebera p a nilai pentingyang mendukung iklim damai. Paper ini memetik nilai-nilai damai ajaran sangSunan tersebut dengan harapan dapat membendung arus ideologi ekstrim yangakhir-akhir ini semakin membanjiri ruang publik.
Valorização, preservação e promoção da cultura local através da economia criativa: o caso da produção do souvenir gastronômico
Authors: De Paula Tauana Macedo , Mecca Marlei Salete 
Published: December 2018

Este artigo aborda como a valorização, a preservação e a promoção da cultura local estão sendo trabalhadas na produção do souvenir gastronômico à luz dos preceitos da Economia Criativa. O campo de análise foi a região turística “Uva e Vinho” – Serra Gaúcha, mais precisamente os souvenirs gastronômicos comercializados na estação do passeio de trem “Maria Fumaça”, em Bento Gonçalves/RS. Dessa forma, esta pesquisa caracterizase, metodologicamente, por ser exploratória quanto aos seus objetivos; nos procedimentos técnicos predomina o estudo de caso; já a coleta de dados foi realizada através de uma entrevista semiestruturada. Por fim, os dados foram analisados através do método de triangulação. Os resultados mostram que alguns produtores dos souvenirs gastronômicos valorizam, preservam e promovem a cultura local por meio do resgate de receitas e métodos de produção; na elaboração artesanal, em pouca quantidade, restringindo o acesso à região turística “Uva e Vinho”, entre outros pontos.
MYOCARDIAL PERFUSION AND NEUROTROPIC SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY FEATURES IN PATIENTS WITH PRIMARY PULMONARY HYPERTENSION
Authors: Ansheles A. A. , Kuznetsova E. G. , Martynyuk T. V. , Sergienko V. B. 
Published: December 2018

Objective.To compare cardiac123I-MIBG and99m Tc-MIBI single-photon emission computed tomography (SPECT) data in patients with primary pulmonary hypertension (PPH).Material and methods.The study included 22 patients with confirmed diagnosis of PPH, with clinical status assessment, Holter ECG monitoring and rest cardiac ultrasound (US) data. All patients, as well as a group of healthy volunteers (n=20) underwent myocardial perfusion SPECT with99mTc-MIBI at rest and after treadmill exercise test, and myocardial neurotropic SPECT with123I-MIBG, performed in 15 min (early phase) and 4 hours (delayed phase) after MIBG administration. LV perfusion abnormalities were evaluated using standard SSS and SDS parameters, RV was assessed visually, RV/LV and IVS/LW uptake ratios were calculated. Global sympathetic activity (SA) was assessed with delayed heart/mediastinum ratio (H/Md) and MIBG Washout Rate in 4 hours (WR). Regional SA abnormalities were assessed using early Summed MIBG Score (SMSe). MIBG RV/LV and LV IVS/LW uptake ratios were calculated. All parameters were compared with normal database (n=20).Results.The values of a number of myocardial SPECT parameters, both perfusion (SSS, RV/LVMIBI, IVS/LWMIBI) and neurotropic (H/Md, WR, SMSe, IVS/LWMIBG), were significantly worse in PPH patients compared to the control group (all p<0.05). Perfusion SPECT showed no significant (SDS>4) transient LV ischemia in all patients, but in 77% of cases IVS perfusion was stably impaired, causing overall SSS=7 (6–10), presumably due to IVS compression by dilated RV. MIBI RV/LV ratio was 0.61±0.02, indicating that RV was clearly visible, with inhomogeneous MIBI uptake in all cases, but without reliable perfusion defects. Values of H/Mdwere 1.84±0.18, WR: 27±8%, with no reliable correlations with perfusion parameters. Regional SA defects also were located in IVS predominately, causing SMSemean value of 8 (6–10) and IVS/LW of 0.69±0.09, both parameters correlated with SSS (r=0.44, p=0.04 and r=-0.48, p=0.02, respectively). All parameters, except RV/LVMIBG, had reliable correlations with systolic pulmonary artery pressure assessed by cardiac US, especially RV/LVMIBI(r=0.64, p<0.01), WR (r=0.55, p=0.01) and IVS/LWMIBG(r=-0.49, p=0.02).Conclusion.Combination of myocardial neurotropic and perfusion SPECT has a certain diagnostic value in patients with PPH, since MIBG SPECT reflects SA downregulating, and MIBI SPECT reveals specific microcirculatory abnormalities in these patients, both possibly caused by myocardial pressure overload and responsible for angina-like symptoms.
Optimal design of carbon fiber collapsible hinge for space application
Authors: Hua Haitao , Sun Beibei 
Published: December 2018

In order to design the optimal size of carbon fiber collapsible hinge for space engineering application, the modal and folding analysis of carbon fiber collapsible hinge is carried out in this paper. Natural frequencies and mode shapes are investigated through finite element model. The result is also verified by modal experiments. The maximum stress during folding process of the hinge is obtained by quasi-static simulation analysis. In order to increase the stiffness and stability of this collapsible structure, the fundamental frequency and maximum stress are optimized with respect to the hinge size. A co-simulation optimal design method is proposed in this paper. The optimal hinge size is obtained through non-dominated sorting genetic algorithm based on radial basis function neural network surrogate model. The fundamental frequency is increased by 12 %, while the maximum stress is decreased by 13 % after optimal design.
Development of an automatic pulling mechanism of probe plug in marine eXpendable BathyThermograph launching system
Authors: Guangyuan Chen , Zhuo Lei , Haijing He 
Published: December 2018

Marine eXpendable Bathythermograph (XBT) launching system is used to launch detecting probes into the ocean quickly and efficiently and has been researched for many years. The probes will measure the ocean parameters of depth and temperature during droppings which make the device with the merits of real-time, fast and wide spreading. The automatic pulling mechanism of probe plug is an important part of XBT automatic launching system which improves the shortcoming of hand-held launch method of XBT probe. This development mentioned a kind of automatic extraction mechanism for probe’s plug fixed the probe. The lever is adopted here to magnify the tensile force in order to draw out the plug in limited stroke. That will make sure the full-automatic launching of expendable probes. In tests, the successful dropping rate is over 95 % and save time over 50 % more than hand-held method which prove the automatic extraction mechanism effect and reliable. The mechanism also can be used into various automatic launchers of expendable probes through a little configuration adjust. Its broad application prospect is viewed.
Synthesis and Biological Studies of New Multifunctional Curcumin Platforms for Anticancer Drug Delivery
Authors: Bazylevich Andrii , Tuchinsky Helena , Zigman-Hoffman Eti , Weissman Ran , Shpilberg Ofer , Hershkovitz-Rokah Oshrat , Patsenker Leonid , Gellerman Gary 
Published: December 2018

Background:
Scientists have extensively investigated curcumin, yielding many publications
on treatments of cancer. Numerous derivatives of curcumin were synthesized, evaluated for
their anti-oxidant and free-radical scavenging, SAR, ADME properties and tested in anticancer applications.

Objective:
We decided to exploit curcumin as a bioactive core platform for carrying anticancer
drugs, which likely possesses a carboxyl moiety for potential linkage to the carrier for drug delivery.

Methods:
The goal of this work is to develop biolabile multifunctional curcumin platforms towards
anticancer drug delivery, including determination of drug release profiling in hydrolytic
media, in vitro cytotoxicity, antioxidant properties and blockage of relevant cell survival pathways.

Results:
We report on a facile synthesis of the bioactive multifunctional curcumin-based platforms
linked to a variety of anticancer drugs like amonafide and chlorambucil, and release of the drugs in
a hydrolytic environment. The leading curcumin-based platform has presented antioxidant activity
similar to curcumin, but with much more potent cytotoxicity in vitro in agreement with the augmented
blockage of the NF-kB cell survival pathway.

Conclusion:
The approach presented here may prove beneficial for bioactive curcumin-based delivery
applications where multiple drug delivery is required in a consecutive and controlled mode.
Efficacy of Novel Schiff base Derivatives as Antifungal Compounds in Combination with Approved Drugs Against Candida Albicans
Authors: Malik Manzoor Ahmad , Lone Shabir Ahmad , Gull Parveez , Dar Ovas Ahmad , Wani Mohmmad Younus , Ahmad Aijaz , Hashmi Athar Adil 
Published: December 2018

Background:The increasing incidence of fungal infections, especially caused by Candida albicans, and their increasing drug resistance has drastically increased in recent years. Therefore, not only new drugs but also alternative treatment strategies are promptly required.Methods:We previously reported on the synergistic interaction of some azole and non-azole compounds with fluconazole for combination antifungal therapy. In this study, we synthesized some non-azole Schiff-base derivatives and evaluated their antifungal activity profile alone and in combination with the most commonly used antifungal drugs- fluconazole (FLC) and amphotericin B (AmB) against four drug susceptible, three FLC resistant and three AmB resistant clinically isolated Candida albicans strains. To further analyze the mechanism of antifungal action of these compounds, we quantified total sterol contents in FLC-susceptible and resistant C. albicans isolates.Results:A pyrimidine ring-containing derivative SB5 showed the most potent antifungal activity against all the tested strains. After combining these compounds with FLC and AmB, 76% combinations were either synergistic or additive while as the rest of the combinations were indifferent. Interestingly, none of the combinations was antagonistic, either with FLC or AmB. Results interpreted from fractional inhibitory concentration index (FICI) and isobolograms revealed 4-10-fold reduction in MIC values for synergistic combinations. These compounds also inhibit ergosterol biosynthesis in a concentration-dependent manner, supported by the results from docking studies.Conclusion:The results of the studies conducted advocate the potential of these compounds as new antifungal drugs. However, further studies are required to understand the other mechanisms and in vivo efficacy and toxicity of these compounds.
MMP7 Induces T-DM1 Resistance and Leads to the Poor Prognosis of Gastric Adenocarcinoma via a DKK1-Dependent Manner
Authors: Li Hua , Xu Xin , Liu Yang , Li Shunle , Zhang Di , Meng Xiaofen , Lu Le , Li Yiming 
Published: December 2018

Background:
Gastric adenocarcinoma is one of the most common and lethal cancer types and is known as
the second leading cause of cancer-related death of Asian adults, early diagnosis based on either pathology or molecular
biology could be one of the most efficient ways to improve the outcomes of gastric adenocarcinoma patients.

Methods:
Quantitative Real-Time PCR and Western-blot were used in detection of mRNA and protein expression.
Lentivirus infection was used to overexpression or knock down target gene. Alarma blue assay was used to monitor
cells proliferation. Flow cytometry analysis was performed to test protein expression and apoptosis level. Immunohistochemistry
was used to identify protein expression in tissue. Statistical differences between two groups are evaluated
by two-tailed t-tests. The comparison among multiple groups is performed by one-way Analysis of Variance
(ANOVA) followed by Dunnett’s posttest. The statistical significance of the Kaplan-Meier survival plot is determined
by log-rank analysis.

Results:
MMP7 as one of the most up-regulated genes in T-DM1 resistant NCI-N87 gastric adenocarcinoma cells
compared to matched naïve cell lines. T-DM1 resistant NCI-N87 cell lines by exposed to T-DM1 in vitro. Exogenous
overexpression of MMP7 promotes T-DM1 resistance and tumor growth in NCI-N87 cell lines while MMP7 knockdown
enhanced sensitivity to T-DM1 in T-DM1 resistant NCI-N87 cell lines established previously. MMP7 was
enriched in high WHO grade GC samples and implies poor outcomes for these patients. DKK1 as one of the most
correlated genes to MMP7 in gastric adenocarcinoma and knock-down of DKK1 or inhibition of Wnt/β-catenin
pathway led to a decreased expression of MMP7 and resistance to T-DM1.

Conclusion:
DKK1 and Wnt/β-catenin-dependent activation of MMP7 induces T-DM1 resistance and leads to the
poor prognosis of gastric adenocarcinoma, which might be a novel potential therapeutical target for T-DM1 resistant
gastric adenocarcinoma.
The Intertwined Relationship Between Job Crafting, Work-Related Positive Emotions, and Work Engagement. Evidence from a Positive Psychology Intervention Study
Authors: Costantini Arianna , Sartori Riccardo 
Published: December 2018

Purpose:The present study examines the impact of a positive psychology intervention on job crafting, positive emotions and work engagement.Design:A sample of 43 employees working in a public organisation received a three day-long resource-based intervention grounded on meaningfulness and practical exercises.Findings:Results showed that the intervention had a positive effect on job crafting, positive job-related affective well-being and work engagement. Moreover, findings from a mediation model show that the intervention was effective in sustaining work engagement resulting from experienced positive emotions, which in turn resulted from job crafting behaviours.Originality/Value:To the best of our knowledge, this study is the first to investigate the intertwined relationships between job crafting behaviours, positive emotions in the workplace, and work engagement. Moreover, our findings provide evidence of the effectiveness of the proposed positive psychology intervention to support work engagement resulting from proactive adjustment to the work environment and the positive emotions deriving from it.
Common Variants of the Plant microRNA-168a Exhibit Differing Silencing Efficacy for Human Low-Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1)
Authors: Lang Claudia , Karunairetnam Sakuntala , Lo Kim R. , Kralicek Andrew V. , Crowhurst Ross N. , Gleave Andrew Peter , MacDiarmid Robin M. , Ingram John Ronald 
Published: December 2018

Background:
The discovery that a plant microRNA (miRNAs) from rice (Oryza sativa
miR168a) can modify post-transcriptional expression of the mammalian. Low-Density Lipoprotein
Receptor Adaptor Protein 1 (LDLRAP1) gene highlights the potential for cross-kingdom miRNAmRNA
interactions.

Objective:
To investigate whether common variants of the conserved miR168a family have the capability
for similar cross-kingdom regulatory functions, we selected sequences from three dietary plant
sources: rice (Oryza sativa), tomato (Solanum lycopersicum), apple (Malus domestica) and compared
their ability to regulate human LDLRAP1 expression.

Methods:
Target prediction software intaRNA and RNAhybrid were used to analyze and calculate
the energy and alignment score between the miR168a variants and human LDLRAP1 mRNA. An in
vitro cell-based Dual-Luciferase® Reporter Assay (pmirGLO, Promega), was then used to validate
the miRNA-mRNA interaction experimentally.

Results:
Computational analyses revealed that a single nucleotide difference at position 14 (from the
5’ end of the miRNA) creates a G:U wobble in the miRNA-mRNA duplex formed by tomato and apple
miR168a variants. This G:U wobble had only a small effect on the free energy score (-33.8–34.7
kcal/mol). However, despite reasonable hybridization energy scores (<-20 kcal/mol) for all miR168a
variants, only the rice miR168a variant lacking a G:U wobble significantly reduced LDLRAP1 transcript
expression by 25.8 + 7.3% (p<0.05), as measured by relative luciferase activity.

Conclusion:
In summary, single nucleotide differences at key positions can have a marked influence
on regulatory function despite similar predicted energy scores and miRNA-mRNA duplex structures.
Pengaruh budaya organisasi, penghargaan dan kepercayaan terhadap motivasi berprestasi pegawai Dinas Pendidikan Pemuda dan Olahraga Kabupaten Rokan Hulu
Authors: Hardianto Hardianto 
Published: December 2018

Tujuan penelitian ini untuk menganalisis besarnya pengaruh budaya organisasi, penghargaan dan kepercayaan terhadap motivasi berprestasi pegawai dinas pendidikan pemuda dan olahraga Kabupaten Rokan Hulu. Survei dilakukan terhadap 75 orang pegawai yang dijadikan sampel penelitian dengan teknik simple random sampling. Pengolahan data dilakukan dengan analisis jalur. Hasil penelitian menunjukkan bahwa: (1) budaya organisasi berpengaruh langsung positif terhadap motivasi berprestasi, (2) penghargaan berpengaruh langsung positif terhadap motivasi berprestasi, (3) kepercayaan berpengaruh langsung positif terhadap motivasi berprestasi, (4) budaya organisasi berpengaruh langsung positif terhadap kepercayaan, (5) penghargaan berpengaruh langsung positif terhadap kepercayaan. Berdasarkan hasil penelitian dapat disimpulkan bahwa untuk meningkatkan motivasi berprestasi pegawai dapat dilakukan dengan meningkatkan budaya organisasi, penghargaan dan kepercayaan. Sementara untuk meningkatkan kepercayaan pegawai dapat dilakukan dengan meningkatkan budaya organisasi dan penghargaan.Kata Kunci: budaya organisasi, penghargaan, kepercayaan, motivasi berprestasi THE EFFECT OF ORGANIZATION CULTURE, REWARD, AND TRUST ON ACHIEVEMENT MOTIVATION OF YOUTH AND SPORTS EDUCATION DEPARTMENT OF ROKAN HULU DISTRICTAbstractThe purpose of this study was to analyze the magnitude of the effect of organizational culture, appreciation and trust toward the employees’ achievement motivation of Education, Youth and Sports education Ministery of Rokan Hulu Regency. The survey was conducted on 75 employees. Sample was taken by simple Random Sampling Technique. Data analysis was done by path analysis. The results showed that: 1) Organizational culture has a direct positive effect toward achievement motivation, (2) The reward has a direct positive effect toward achievement motivation, (3) Trust has a direct positive effect toward achievement motivation, (4) Organizational culture has a direct positive effect toward the trust, (5) Reward has a positive direct effect toward the trust. Based on the research results could be concluded that to improve employees’ achievement motivation could be done by improving organizational culture, appreciation, and trust. Meanwhile, to increase the confidence of employees could be done by improving the organizational culture and appreciation.Keywords: organizational culture, reward, trust, achievement motivation
Influence of learning media based on adobe flash professional to psychomotor domain learning outcomes on plc courses viewed from level of creative thinking student
Authors: Muslim Supari , Gitama Nahindi Putra , Suprianto Bambang , Rahmadyanti Erina , Kusumawati Nita 
Published: December 2018

This study uses adobe flash professional based learning media for experimental class while in control class using CourseLab media. Learning media based on adobe flash professional designed in the form of applications for smartphones and computers or notebooks. This study aims to determine the interaction and differences in learning result for students who have low and high creative thinking level who learn by using adobe flash professional media than students who use the media CourseLab. This research was conducted in department D3 mechatronic class of 2015 at State University of Trunojoyo Madura (UTM) on PLC course and using factorial design 2 x 2, with total of students in the experimental class as much as 44 people and total of students in the control class as many as 26 people. Data Processing Technique for hypothesis testing, used two-independent-samples test technique. If the prerequisite test of normality and homogeneity is not met, we will use the mann-whitney u test technique. Research finds: (1) for students who have a low level of creative thinking, who learn by using adobe flash professional learning media, psychomotor domain learning outcomes is significantly higher than students who learn by using instructional media CourseLab; (2) for students who have a high level of creative thinking, who learn by using adobe flash professional learning media, psychomotor domain learning outcomes is significantly higher than students who learn by using instructional media CourseLab; and (3) there is a significant interaction between the level of students' creative thinking and learning media, to psychomotor domain learning outcomes. Research suggests: (1) research subjects used at least more than 150 students, to obtain better data (normal distributed data); and (2) the preparation of tools and materials must be in accordance with the needs to be used, so that the quality of learning is increasing.