bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic value of ultrasound for community-acquired pneumonia in children and its correlation with serum PCT level and PCIS
Authors: Liu Qing-Zhong , Feng Zi-Qiang , Huang Kai-Wei , Yang Zi-Jiang , Xu Li-Qin , Shen Yuan-Yuan 
Published: October 2024

Objective:
This study aimed to evaluate the diagnostic value of ultrasound for community-acquired pneumonia (CAP) in children.

Methods:
Clinical information of children diagnosed with CAP and a control group of healthy children was collected, and lung ultrasound detection was performed. The lung ultrasound score (LUS) was assessed, and venous blood samples were collected. Serum indexes, including white blood cell count, were analyzed using an automatic immunoassay analyzer, while serum procalcitonin (PCT) level was measured using an enzyme-linked immunosorbent assay. The pediatric critical illness score (PCIS) was also performed for all subjects.

Results:
White blood cell count, absolute neutrophil count, and respiratory index were significantly higher in the CAP group than those in the control group, while the oxygenation index was markedly lower. Ultrasound detection results showed that the CAP group exhibited significantly higher detection rates of pleural effusion, interstitial lung changes, lung consolidation, B-lines, air bronchogram signs, and reduced or absent lung sliding signs compared with the control group. In addition, the LUS and PCT levels were markedly higher in the CAP group, while the PCIS was notably lower. Further analysis exhibited that the LUS in the CAP group was significantly positively correlated with PCT levels and negatively correlated with PCIS. The receiver operating characteristic curve indicated that the area under the curve of LUS for diagnosing children with lung infection was 0.841.

Conclusion:
LUS is closely related to serum PCT level and PCIS. Lung ultrasound detection demonstrates high sensitivity and specificity, indicating its valuable clinical diagnostic utility for CAP in children.
Systemic lupus erythematosus with podocyte infolding glomerulopathy: A case report and literature review
Authors: Zhang Huiqing , Lin Jie , Lu Hanqi , Zhong Yunliang , Deng Lie , Kuang Bin , Li Qiang 
Published: October 2024

Rationale:
Podocyte infolding glomerulopathy (PIG) is a rare glomerular disease, its diagnosis mainly depends on pathological manifestations of the kidney. Few clinical cases of PIG have been reported, but it is sometimes associated with connective tissue diseases. Here we describe a case of systemic lupus erythematosus (SLE) with PIG and undertake a review of the literature.

Patient concerns:
A 34-year-old female patient was admitted to our hospital in August 2019 with repeated facial erythema and proteinuria for more than 10 years. The patient was previously diagnosed with SLE.

Diagnosis:
Systemic lupus erythematosus.

Interventions:
Renal biopsy was performed to investigate ongoing proteinuria and the results were consistent with PIG. Treatment with methylprednisolone, hydroxychloroquine sulfate, mycophenolate mofetil, and candesartan ester.

Outcomes:
Improved the patient’s condition and resolved the proteinuria.

Lessons:
This study reported a case of PIG and SLE. The patient was diagnosed according to biopsy, and the disease remain stable after immunosuppressive therapy. It is recommended to carefully study renal biopsies from patients with proteinuria and underlying autoimmune diseases to identify additional cases.
Efficacy and safety of traditional Chinese medicine for the treatment of epilepsy by wind quenching and phlegm resolving: A systematic review and meta-analysis
Authors: Cai Yufen , He Xiaofang , Ao Liting , Liu Yibo , Zhang Yanju , Yang Hui , Zhang Lin 
Published: October 2024

Background:
Using wind-quenching and phlegm-resolving (WQPR) therapy for epilepsy has yielded beneficial results in various clinical studies. However, a comprehensive analysis of the WQPR approach to epilepsy has not yet conducted to date. This study aimed to evaluate the effectiveness and safety of the WQPR method in traditional Chinese medicine (TCM) for epilepsy.

Methods:
Eight databases, including The Cochrane Library, Web of Science, PubMed, Embase, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Chinese Science and Technology Periodical Database (VIP), and WanFang Database, were comprehensively searched to include randomized controlled trials (RCTs) investigating the WQPR approach in epilepsy. Quality was evaluated by the Cochrane Handbook for Systematic Reviews of Interventions, and meta-analysis was conducted using the RevMan 5.4 and Stata 14.0 software. For the outcome indicators with the number of studies ≥ 10, funnel chart and Egger test were used to evaluate the bias, and the evidence quality was evaluated according to GRADEpro system.

Results:
We included 19 randomized controlled trials with 1475 participants. Compared to the control group, the WQPR approach showed clinical efficacy for epilepsy (odds ratio = 3.23, 95% confidence interval [CI] [2.19, 4.77], Z = 5.90, P < .00001), reduced seizure frequency (standardized mean differences = ‐1.24, 95% CI [‐1.62, −0.85], Z = 6.26, P < .00001), shortened seizure duration (standardized mean differences = ‐2.07, 95% CI [‐2.99, ‐1.14], Z = 4.39, P < .0001), improved patient’s quality of life (mean difference = 2.60, 95% CI [2.16, 3.03], Z = 11.62, P < .00001), and ameliorated TCM syndromes (mean difference = ‐4.37, 95% CI [‐6.19, ‐2.56], Z = 4.72, P < .00001). The reduced rate of adverse reactions (odds ratio = 0.56, 95% CI [0.37, 0.85], Z = 2.71, P = .007).

Conclusion:
WQPR therapy appears to be an effective and safe approach for treating epilepsy, increasing clinical efficacy, reducing seizures’ frequency and duration, improving patients’ quality of life, ameliorating TCM syndromes, and reducing adverse reaction rates.
Can extracorporeal shock wave therapy be effective in temporomandibular joint disorder?: A pilot study
Authors: Keskin Tunç Serap , Ünalan Değirmenci Beyza , Bilen Mustafa , Toprak Mehmet Emin , Kaplan Şehmus , Turan Mahfuz 
Published: October 2024

Background:
This study aimed to compare extracorporeal shock wave therapy (ESWT) with the use of stabilization splint in nonsurgical temporomandibular disorders treatments, and to evaluate the effects.

Methods:
In this study, individuals, who are diagnosed with disc displacements with reduction according to the diagnostic criteria for temporomandibular disorder examination criteria. The patients in the first control group (n = 36) were applied a medical treatment + stabilization splint. The second group (n = 25) was applied the ESWT (2 days a week for 4 weeks) + medical treatment + stabilization splint. Visual Analog Scale scores, painless maximum painless mouth opening, and passive-forced mouth opening measurements were recorded for the first and second weeks.

Results:
The ESWT application significantly contributed to pain-reducing (Visual Analog Scale) in patients at short notice (P = .030) in the second group. There were statistically significant differences between the groups in painless maximum active mouth opening (P = .009) and passive forced measurements (P = .004) in the second week.

Conclusion:
This pilot study showed that short-term ESWT addition to stabilization splint and medical treatment may yield satisfactory outcomes.
Trousseau syndrome with recurrent cerebral infarction as the first oneset in a gastrointestinal malignant tumor patient: A case report
Authors: Meng Chaoyue , Feng Yuyao , Yang Yi , Zhang Kun , Wang Rui , Wang Ye , Tian Jing , Liu Xiaoyun 
Published: October 2024

Rationale:
Trousseau syndrome (TS) is a thrombosis disorder characterized by a hypercoagulable state linked to underlying malignancies, resulting in various thrombotic events such as deep vein thrombosis, pulmonary embolism, and arterial thrombosis. This syndrome serves as a crucial indicator of malignancy and can often be the first sign of an underlying tumor. In this case, we report a case of gastrointestinal malignant tumor as the first onset, and analyzes its clinical characteristics to improve the clinicians’ understanding of this kind of disease.

Patient concerns:
A 69-year-old woman was admitted to the hospital 4 times in 1 month for cerebral infarction. The patient was admitted several times with a new cerebral infarction lesion and a high D-dimer level, a persistently positive fecal occult blood test, and a gastrointestinal tumor was later found.

Diagnosis:
The patient was diagnosed with TS, attributed to her underlying malignancy.

Interventions:
During hospitalization, the patients were treated with aspirin for antiplatelet, esomeprazole for protection of gastric mucosa, atorvastatin for lowering blood lipids, butylphthalein for improvement of collateral circulation, edaravone dextrocamphorol for scavenging oxygen free radicals, and betahistine hydrochloride tablets for preventing dizziness.

Outcomes:
The patient’s condition improved significantly after initial treatment, but died of the tumor a year after discharge.

Lessons:
Currently, TS has a complex and varied clinical presentation and is relatively difficult to diagnose, especially in patients with an unknown tumor history. Focus should be placed on patients with recurrent cerebral infarctions and increased D-dimer levels, and anticoagulation may be an effective treatment for patients with TS.
Immune checkpoint inhibitor therapy for primary neuroendocrine carcinoma of the gallbladder: A case report and literature review
Authors: Li Chao , Lv Pan , Yanyan Liu , Yin Maohui , Li Hao 
Published: October 2024

Rationale:
Gallbladder neuroendocrine carcinoma (GNEC) is indeed a relatively rare malignant tumor of the gallbladder with neuroendocrine differentiation and the ability to produce and secrete a number of neurotransmitters and hormones, characteristics that make its clinical presentation and biological behavior likely to be different from those of other types of gallbladder cancer. Current treatment mostly relies on surgery and adjuvant chemotherapy and radiotherapy.

Patient concerns:
We report a 53-year-old middle-aged male patient who underwent radical surgery for gallbladder malignancy after a diagnosis of neuroendocrine carcinoma of the gallbladder.

Diagnoses:
Diagnosis of neuroendocrine carcinoma of the gallbladder based on the return of pathologic findings.

Intervention:
After local progression of postoperative chemotherapy with the first-line regimen of etoposide + cisplatin, an immune checkpoint inhibitor (traplizumab) + FOLIFIRI (fluorouracil + calcium folinate + irinotecan) regimen was used.

Outcomes:
The patient achieved 20 months of clinical survival and ultimately died of myelosuppression.

Lessons:
The use of immune checkpoint inhibitors may become an effective tool in the treatment of neuroendocrine carcinoma of the gallbladder.
Ovarian carcinosarcoma with lung metastasis characterized by persistent fever: A case report and literature review
Authors: Wang Weijing , Ji Xuechao , Yang Hanchao , Wang Xinbo 
Published: October 2024

Rationale:
Ovarian carcinosarcoma (OCS) is a rare malignant tumor prone to distant metastasis. Primary manifestations include pelvic and/or abdominal pain, bloating, and compression. Nevertheless, it is uncommon for OCS to present primarily with persistent fever. This is the first reported case of OCS with lung metastasis characterized by persistent fever.

Patient concerns:
A 61-year-old female patient complaining of abdominal pain and fever was admitted to our hospital. Computed tomography showed an irregular, slightly low-density mass on the left side of the uterus and multiple solid nodules in both lungs.

Diagnoses:
She underwent cytoreductive surgery for pathologically confirmed stage IVB OCS.

Interventions:
She was administered chemotherapy after cytoreductive surgery. Given the patient’s history of persistent fever and progressively enlarged pulmonary nodules, a pulmonary abscess was considered as a possible diagnosis. Following antibiotic therapy, the patient’s high body temperature did not decrease; however, following nonsteroidal anti-inflammatory drug therapy, it quickly decreased. These symptoms were eventually considered the consequence of neoplastic fever caused by lung metastases.

Outcomes:
Owing to the rapid progression of the disease, the patient ultimately died.

Lessons:
This study suggests that, for patients with pelvic and/or abdominal pain, bloating, and pelvic masses, especially those with suspicious lesions in other organs accompanied by fever of unknown origin, a diagnosis of cancer or sarcoma with metastasis should be considered after ruling out infectious fever.
Integrating network pharmacology, molecular docking, and experimental validation to reveal the mechanism of Radix Rehmanniae in psoriasis
Authors: Mo Nian , Zhou Panyu , Liu Fanlu , Su Haojie , Han Ling , Lu Chuanjian 
Published: October 2024

Background:
Radix Rehmanniae (RR) plays an important role in treating psoriasis. However, the active compounds of RR and potential mechanisms are unclear. The current study was designed to investigate the potential active ingredients, targets, and mechanisms of RR in treating psoriasis through network pharmacology, molecular docking, and vitro experiments.

Methods:
Initially, the TCMSP database and literature retrieval were used to access the active ingredients of RR. The psoriasis target proteins were obtained from Therapeutic Target Database, OMIM, GeneCards, and DrugBank databases. The target proteins were then converted into target genes using Uniprot. Secondly, overlapping genes were obtained through Venn online tool. Then, protein–protein interactions network diagram is finished by STRING database. Next, Cytoscape software was used to acquire the top 10 hub proteins; gene ontology and Kyoto encyclopedia of genes and genomes enrichment analysis were then used to predict possible mechanisms. Afterwards, molecular docking validation of the active ingredients with the main targets was performed by AutoDock software. Finally, lipopolysaccharides induced RAW264.7, to assess the effects and molecular mechanisms by MTT, RT-qPCR, and Western blot assays.

Results:
Overall, there are 20 effective compounds and 33 targets involved in biological processes including apoptosis, intracellular signaling, vasodilation, and mitogen-activated protein kinase (MAPK) signaling cascade. The docking results showed strong binding capacity between the active ingredients and targets. We verified aucubin as the key active ingredient, tumor necrosis factor α, and IL6 as the core targets, and focused on the p38MAPK protein pathway. Cellular experiments showed that aucubin down-regulated the phosphorylated p38MAP protein and reduced the expression of tumor necrosis factor α mRNA, IL6 mRNA, and IL1βmRNA.

Conclusion:
In summary, RR is featured with multicomponent, multi-target, and multi-pathway in treating psoriasis; the preliminary mechanism may be associated with the down-regulation of p38MAPK phosphorylation and curbing the expression of inflammatory factor by aucubin. This paper provides the scientific basis for Traditional Chinese medicine treating psoriasis.
Bibliometric analysis of orexin: A promising neuropeptide
Authors: Sun Ning , Wei Rui , Jia Bochao , Lou Taiwei , Li Zirong , Nie Xiaowei , Yu Wenxiao , Zhao Ming , Li Qiuyan 
Published: October 2024

Background:
Orexin is an excitatory neuropeptide produced in the lateral hypothalamus, playing a role in various physiological functions in humans. There is a growing body of literature on orexins. This paper utilizes CiteSpace software to organize and analyze a significant number of articles on orexin, providing readers with an intuitive overview of research trends and emerging hot topics in this field.

Methods:
The electronic database, Web of Science Core Collection (WoSCC), was searched for publications related to orexins. Annual publications, countries/regions, institutions, authors and keywords were analyzed, and the results were visualized via CiteSpace software.

Results:
A total of 5486 publications were included, with articles making up 85.30% and reviews 14.70%. The top 3 countries publishing the most papers on orexins were the United States (2057 papers), Japan (778), and China (556). The leading institutions included Research Libraries UK (278), Harvard University (250), and Stanford University (221). The most prolific authors in the field were Yves Dauvilliers (69), Abbas Haghparast (67), and Takeshi Sakurai (66). The most frequently used keywords were “neurons” (981), followed by “sleep” (824), “food intake” (612), “receptors” (547), and “neuropathology” (535). Recent research hotspots include melanin-concentrating hormone neurons, Alzheimer disease, gamma-aminobutyric acid neurons, oxidative stress, suvorexant, the orexin system, prevalence, and stress. Based on keyword clustering analysis, the top 5 research hotspots from 2003 to 2022 were: the effects of orexins on sleep and metabolism, potential pathways of orexin signaling, the relationship between orexin and immunity, new findings on depression and hypertension related to orexin, and possible targets for neurodegenerative diseases.

Conclusion:
Orexin, a neuropeptide linked to various physiological and pathological processes, plays a crucial role in sleep/wakefulness, reward mechanisms, stress responses, and neurodegenerative diseases. Its significant research value and potential medical applications are underscored by the rapid expansion of studies, particularly in the USA and Japan. However, the lack of collaboration among researchers highlights the need for enhanced academic exchange and cooperation to further advance the field of orexin research.
Evaluating the impact of rational emotive behavior therapy on post-traumatic stress in farmers with experiences of natural disaster
Authors: Nwankwo Clara U. , Egbule Elizabeth Osita , Ede Kelechi Ruth , Ede Moses Onyemaechi , Victor-Aigbodion Vera , Ifere Paul Ikechukwu , Nweze Celestina Adaeze , Obeagu Emmanuel Ifeanyi 
Published: October 2024

Background/objective:
This study was necessary due to the increasing number of cases of natural disasters such as flood, air pollution, erosion, etc in Nigeria, particularly in the Abia state, as well as the accompanying psychological and health issues affecting individuals within families and society as a whole. The study aimed to examine the impact of rational emotive behavior therapy on farmers’ post-traumatic stress (PTS) in Abia State, Nigeria.

Method:
A randomized control trial was conducted in Abia state, with a sample size of 118 farmers with experiences of natural disasters. Two assessments were conducted before the treatment, immediately after the treatment, and 2 months later to evaluate PTS and irrational beliefs among the farmers. The treatment involved a self-developed PTS-focused rational emotive behavior therapy manual, consisting of 12 sessions lasting 60 minutes each, delivered by counseling psychologists trained in rational emotive behavior and family therapies. Data from the pretest, posttest, and follow-up test were analyzed using chi-square, percentage, partial eta squared, and analysis of covariance statistical tools.

Results:
The results showed no significant gender differences in the socioeconomic status, employment, and debt status of the participants. The rational emotive behavior therapy was effective in reducing PTS caused by the flood among farmers. Gender did not have a significant moderating effect on farmers’ experiences with PTS.

Conclusion:
The study suggested that family health specialists and rational-emotive therapists collaborate with local authorities to provide career counseling services to farmers and establish community-based rational emotive institutes in each state of Nigeria.
Nursing bibliometric analysis of wound infections
Authors: Liu Mengdi , Ma Cuifang , Dong Xiaowei , Gu Mengyi , Wang Zheng , Gao Qian , Guo Xiaoyu 
Published: October 2024

Background:
This paper aims to perform a bibliometric analysis of research pertaining to the nursing care of infected wounds. It also aims to examine the current focal points and trends in research development. The paper offers research references that may be useful for practitioners interested in related areas.

Methods:
The Web of Science Core Collection database was queried for publications pertaining to infected wound care. Publication trends and proportions were analyzed using Graphpad Prism v8.0.2. CiteSpace (6.2.4R [64-bit]) and VOSviewer (version 1.6.18) were employed to assess the literature and conduct mapping.

Results:
The Web of Science Core Collection database contains 3868 literature related to wound infection care, including 3327 articles and 541 reviews. The literature concerned 117 countries and territories, 4673 institutions, and 20,161 authors. The growth rate of literature was relatively slow before 2015 and markedly accelerated after 2016. Among them, the United States occupies the absolute dominance in research in this field, publishing 37.25% of the papers, and the United States occupies 8 of the top 10 scientific institutions that publish papers. The University of Harvard has published the largest number of papers. Keyword analysis shows a total of 1125 keywords, and through reference literature and time clustering analysis shows that wound healing, sepsis, spine surgery, postoperative infection, nanocrystalline silver, beta lactamase are the current research hotspots.

Conclusion:
The escalating rate of literary expansion since 2016 suggests that this domain is garnering an increasingly significant amount of interest. Minimizing the risk of patient wound infection is crucial in reducing patients’ discomfort and facilitating their prompt recovery. The literature analysis presented in this study serves as a valuable resource for comprehending the current state of the subject and identifying the current areas of focus.
A bibliometric and visualization analysis of global trends and frontiers on macrophages in abdominal aortic aneurysms research
Authors: Zhang Liang , Li Dongyu , Bao Shiyang 
Published: October 2024

Background:
Macrophages are key regulators of the inflammatory and innate immune responses. Researchers have shown that aberrant expression of macrophages contributes to the development of abdominal aortic aneurysms (AAA). However, a comprehensive bibliometric analysis exploring the research status and knowledge mapping of this area is lacking. This study aimed to explore the research status, knowledge mapping and hotspots of macrophages in AAA research from a bibliometric perspective.

Methods:
In this study, we retrieved articles published between 2000 and 2022 on macrophages associated with AAA research from the Web of Science Core Collection (WoSCC) database. The retrieved literature data were further analyzed using Citespace and VOSviewer software.

Results:
A total of 918 qualified publications related to AAA-associated macrophages were retrieved. The number of publications in this field has been increasing annually. China and the United States were the 2 main drivers in this field, contributing to more than 64% of the publications. In addition, the US had the most publications, top institutions, and expert researchers, dominating in research on macrophages in AAA. The Harvard University was the most productive institution, with 60 publications. The journal with the most publications was Arteriosclerosis, Thrombosis, and Vascular Biology (86). Daugherty Alan was the most prolific author (28 publications) and he was also the most cited co- author. Furthermore, the exploration of established animal models, macrophage-related inflammatory-microenvironment, macrophage-related immune mechanism, clinical translation and molecular imaging research remained future research directions in this field.

Conclusions:
Our findings offered new insights for scholars in this field. They will help researchers explore new directions for their work.