bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of functional dorsal attention network alterations with breast cancer and chemotherapy
Authors: Shen Chao-Yu , Chen Vincent Chin-Hung , Yeh Dah-Cherng , Huang Shu-Ling , Zhang Xuan-Ru , Chai Jyh-Wen , Huang Yen-Hsun , Chou Ming-Chih , Weng Jun-Cheng 
Published: January 2019

AbstractBreast cancer is the most common cancer among women worldwide. Adjuvant chemotherapy has significantly reduced mortality but increased cognitive impairments, including attention function, making quality of life issues a crucial concern. This study enrolled nineteen breast cancer patients who were treated with standard chemotherapy within 6 months and 20 sex-matched healthy controls to investigate the brain effects of chemotherapy. All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) with mean fractional amplitude of low-frequency fluctuation (mfALFF) analysis and were correlated with neuropsychological tests, including the Mini-Mental State Examination (MMSE), the Cognitive and Affective Mindfulness Scale-Revised (CAMS-R), and the Impact of Event Scale-Revised (IES-R), to explore the possible underlying mechanism of cognitive alternations. We found increased mfALFF over the frontoparietal lobe and decreased mfALFF over the occipital lobe in the cancer patients compared with the healthy controls; the altered brain regions may be associated with the dorsal attention network (DAN) and may be explained by a compensatory mechanism. Both MMSE and CAMS-R scores showed a positive correlation with mfALFF in the occipital lobe but a negative correlation in the frontoparietal lobe. By contrast, IES-R scores showed a positive correlation with mfALFF in the frontoparietal lobe but a negative correlation in the occipital lobe. These alterations are potentially related to the effects of both chemotherapy and psychological distress. Future research involving a larger sample size of patients with breast cancer is recommended.
A tonal-language benefit for pitch in normally-hearing and cochlear-implanted children
Authors: Deroche Mickael L. D. , Lu Hui-Ping , Kulkarni Aditya M. , Caldwell Meredith , Barrett Karen C. , Peng Shu-Chen , Limb Charles J. , Lin Yung-Song , Chatterjee Monita 
Published: January 2019

AbstractIn tonal languages, voice pitch inflections change the meaning of words, such that the brain processes pitch not merely as an acoustic characterization of sound but as semantic information. In normally-hearing (NH) adults, this linguistic pressure on pitch appears to sharpen its neural encoding and can lead to perceptual benefits, depending on the task relevance, potentially generalizing outside of the speech domain. In children, however, linguistic systems are still malleable, meaning that their encoding of voice pitch information might not receive as much neural specialization but might generalize more easily to ecologically irrelevant pitch contours. This would seem particularly true for early-deafened children wearing a cochlear implant (CI), who must exhibit great adaptability to unfamiliar sounds as their sense of pitch is severely degraded. Here, we provide the first demonstration of a tonal language benefit in dynamic pitch sensitivity among NH children (using both a sweep discrimination and labelling task) which extends partially to children with CI (i.e., in the labelling task only). Strong age effects suggest that sensitivity to pitch contours reaches adult-like levels early in tonal language speakers (possibly before 6 years of age) but continues to develop in non-tonal language speakers well into the teenage years. Overall, we conclude that language-dependent neuroplasticity can enhance behavioral sensitivity to dynamic pitch, even in extreme cases of auditory degradation, but it is most easily observable early in life.
An MR technique for simultaneous quantitative imaging of water content, conductivity and susceptibility, with application to brain tumours using a 3T hybrid MR-PET scanner
Authors: Liao Yupeng , Oros-Peusquens Ana-Maria , Lindemeyer Johannes , Lechea Nazim , Weiß -Lucas Carolin , Langen Karl-Josef , Shah N. Jon 
Published: January 2019

AbstractApproaches for the quantitative mapping of water content, electrical conductivity and susceptibility have been developed independently. The purpose of this study is to develop a method for simultaneously acquiring quantitative water content, electrical conductivity and susceptibility maps based on a 2D multi-echo gradient echo sequence. Another purpose is to investigate the changes in these properties caused by brain tumours. This was done using a 3T hybrid magnetic resonance imaging and positron emission tomography (MR-PET) scanner. Water content maps were derived after performing T2* and transmit-receive field bias corrections to magnitude images essentially reflecting only the H2O content contrast. Phase evolution during the multi-echo train was used to generate field maps and derive quantitative susceptibility, while the conductivity maps were retrieved from the phase value at zero echo time. Performance of the method is demonstrated on phantoms and two healthy volunteers. In addition, the method was applied to three patients with brain tumours and a comparison to maps obtained from PET using O-(2-[18 F]fluoroethyl)-L-tyrosine and clinical MR images is presented. The combined information of the water content, conductivity and susceptibility may provide additional information about the tissue viability. Future studies can benefit from the evaluation of these contrasts with shortened acquisition times.
Counting circulating endothelial cells in allo-HSCT: an ad hoc designed polychromatic flowcytometry-based panel versus the CellSearch System
Authors: Almici Camillo , Neva Arabella , Skert Cristina , Bruno Benedetto , Verardi Rosanna , Di Palma Andrea , Bianchetti Andrea , Braga Simona , Piovani Giovanna , Cancelli Valeria , Omedè Paola , Baeten Kurt , Rotta Gianluca , Russo Domenico , Marini Mirella 
Published: January 2019

AbstractPhysio-pathologic interrelationships between endothelial layer and graft-versus-host disease (GVHD) have been described leading to assess the entity “endothelial GVHD” as the early step for clinical manifestations of acute GVHD. The availability of the CellSearch system has allowed us to monitor Circulating Endothelial Cells (CEC) changes in allogeneic hematopoietic stem cell transplantation (allo-HSCT) as useful tool to help clinicians in GVHD diagnostic definition. We have compared CEC counts generated by an ad hoc designed polychromatic-flowcytometry (PFC) Lyotube with those of the CellSearch system. CEC were counted in parallel at 5 timepoints in 50 patients with malignant hematologic disorders undergoing allo-HSCT (ClinicalTrials.gov, NCT02064972). Spearman rank correlation showed significant association between CEC values at all time points (p = 0.0001). The limits of agreement was demonstrated by Bland Altman plot analysis, showing bias not significant at T1, T3, T4, while at T2 and T5 resulted not estimable. Moreover, Passing Bablok regression analysis showed not significant differences between BD Lyotube and CellSearch system. We show that CEC counts, generated with either the CellSearch system or the PFC-based panel, have a superimposable kinetic in allo-HSCT patients and that both counting procedures hold the potential to enter clinical routine as a suitable tool to assist clinicians in GVHD diagnosis.
Tunable plasmonic resonances in Si-Au slanted columnar heterostructure thin films
Authors: Kılıç Ufuk , Mock Alyssa , Feder René , Sekora Derek , Hilfiker Matthew , Korlacki Rafał , Schubert Eva , Argyropoulos Christos , Schubert Mathias 
Published: January 2019

AbstractWe report on fabrication of spatially-coherent columnar plasmonic nanostructure superlattice-type thin films with high porosity and strong optical anisotropy using glancing angle deposition. Subsequent and repeated depositions of silicon and gold lead to nanometer-dimension subcolumns with controlled lengths. We perform generalized spectroscopic ellipsometry measurements and finite element method computations to elucidate the strongly anisotropic optical properties of the highly-porous Si-Au slanted columnar heterostructures. The occurrence of a strongly localized plasmonic mode with displacement pattern reminiscent of a dark quadrupole mode is observed in the vicinity of the gold subcolumns. We demonstrate tuning of this quadrupole-like mode frequency within the near-infrared spectral range by varying the geometry of Si-Au slanted columnar heterostructures. In addition, coupled-plasmon-like and inter-band transition-like modes occur in the visible and ultra-violet spectral regions, respectively. We elucidate an example for the potential use of Si-Au slanted columnar heterostructures as a highly porous plasmonic sensor with optical read out sensitivity to few parts-per-million solvent levels in water.
Shared neural representations of tactile roughness intensities by somatosensation and touch observation using an associative learning method
Authors: Kim Junsuk , Bülthoff Isabelle , Kim Sung-Phil , Bülthoff Heinrich H. 
Published: January 2019

AbstractPrevious human fMRI studies have reported activation of somatosensory areas not only during actual touch, but also during touch observation. However, it has remained unclear how the brain encodes visually evoked tactile intensities. Using an associative learning method, we investigated neural representations of roughness intensities evoked by (a) tactile explorations and (b) visual observation of tactile explorations. Moreover, we explored (c) modality-independent neural representations of roughness intensities using a cross-modal classification method. Case (a) showed significant decoding performance in the anterior cingulate cortex (ACC) and the supramarginal gyrus (SMG), while in the case (b), the bilateral posterior parietal cortices, the inferior occipital gyrus, and the primary motor cortex were identified. Case (c) observed shared neural activity patterns in the bilateral insula, the SMG, and the ACC. Interestingly, the insular cortices were identified only from the cross-modal classification, suggesting their potential role in modality-independent tactile processing. We further examined correlations of confusion patterns between behavioral and neural similarity matrices for each region. Significant correlations were found solely in the SMG, reflecting a close relationship between neural activities of SMG and roughness intensity perception. The present findings may deepen our understanding of the brain mechanisms underlying intensity perception of tactile roughness.
Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection
Authors: Emal Diba , Rampanelli Elena , Claessen Nike , Bemelman Frederike J. , Leemans Jaklien C. , Florquin Sandrine , Dessing Mark C. 
Published: January 2019

AbstractCalcineurin inhibitor Tacrolimus, is a potent immunosuppressive drug widely used in order to prevent acute graft rejection. Urinary tract infection (UTI) is the most frequent infectious complication in renal transplant patients and long-term use of Tacrolimus might be involved in higher susceptibility to bacterial infections. It remains largely unknown how Tacrolimus affects the host innate immune response against lower and upper UTI. To address this issue, we used experimental UTI model by intravesical inoculation of uropathogenic E.coli in female wild-type mice pre-treated with Tacrolimus or solvent (CTR). We found that Tacrolimus pre-treated mice displayed higher bacterial loads (cystitis, pyelonephritis and bacteremia) than CTR mice. Granulocytes from Tacrolimus pre-treated mice phagocytized less E. coli, released less MPO and expressed decreased levels of CXCR2 receptor upon infection. Moreover, Tacrolimus reduced TLR5 expression in bladder macrophages during UTI. This immunosuppressive state can be explained by the upregulation of TLR-signaling negative regulators (A20, ATF3, IRAK-M and SOCS1) and parallel downregulation of TLR5 as observed in Tacrolimus treated granulocytes and macrophages. We conclude that Tacrolimus impairs host innate immune responses against UTI.
The CHRS Data Portal, an easily accessible public repository for PERSIANN global satellite precipitation data
Authors: Nguyen Phu , Shearer Eric J. , Tran Hoang , Ombadi Mohammed , Hayatbini Negin , Palacios Thanh , Huynh Phat , Braithwaite Dan , Updegraff Garr , Hsu Kuolin , Kuligowski Bob , Logan Will S. , Sorooshian Soroosh 
Published: January 2019

AbstractThe Center for Hydrometeorology and Remote Sensing (CHRS) has created the CHRS Data Portal to facilitate easy access to the three open data licensed satellite-based precipitation datasets generated by our Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks (PERSIANN) system: PERSIANN, PERSIANN-Cloud Classification System (CCS), and PERSIANN-Climate Data Record (CDR). These datasets have the potential for widespread use by various researchers, professionals including engineers, city planners, and so forth, as well as the community at large. Researchers at CHRS created the CHRS Data Portal with an emphasis on simplicity and the intention of fostering synergistic relationships with scientists and experts from around the world. The following paper presents an outline of the hosted datasets and features available on the CHRS Data Portal, an examination of the necessity of easily accessible public data, a comprehensive overview of the PERSIANN algorithms and datasets, and a walk-through of the procedure to access and obtain the data.
The OpenEar library of 3D models of the human temporal bone based on computed tomography and micro-slicing
Authors: Sieber Daniel , Erfurt Peter , John Samuel , Santos Gabriel Ribeiro Dos , Schurzig Daniel , Sørensen Mads Sølvsten , Lenarz Thomas 
Published: January 2019

AbstractVirtual reality surgical simulation of temporal bone surgery requires digitized models of the full anatomical region in high quality and colour information to allow realistic texturization. Existing datasets which are usually based on microCT imaging are unable to fulfil these requirements as per the limited specimen size, and lack of colour information. The OpenEar Dataset provides a library consisting of eight three-dimensional models of the human temporal bone to enable surgical training including colour data. Each dataset is based on a combination of multimodal imaging including Cone Beam Computed Tomography (CBCT) and micro-slicing. 3D reconstruction of micro-slicing images and subsequent registration to CBCT images allowed for relatively efficient multimodal segmentation of inner ear compartments, middle ear bones, tympanic membrane, relevant nerve structures, blood vessels and the temporal bone. Raw data from the experiment as well as voxel data and triangulated models from the segmentation are provided in full for use in surgical simulators or any other application which relies on high quality models of the human temporal bone.
Fault direction identification for wind power integration system
Authors: Chen Yu , Wen Minghao , Hu Liexiang , Qi Xuanwei , Zheng Junchao , Wang Zhen 
Published: January 2019

Traditional directional relays of AC transmission lines are usually based on 50 Hz information in frequency domain in China. However, this conventional approach cannot provide the correct fault direction for the lines connected to wind farm because of the fault characteristics of the wind power system, that is, frequency deviation, variation of system impedance, weak feed feature, and so on. Then, the conventional approach of finding the phase angle between the fault current and a voltage signal will not identify the correct fault direction. To solve this problem, this paper proposes a novel fault direction identification method in time domain. Based on the RL model of transmission lines, opposite‐side voltages of the line can be derived with the measuring current and voltage at wind farm terminal after the fault. Then, the adjusted cosine similarity between the calculation voltage based on the RL model and the memory voltage can be acquired. If the correlation between the calculation voltage and the memory voltage is close to 1, it is a reverse fault. Otherwise, it is a forward fault. Finally, the proposed novel fault direction identification criterion is verified by the PSCAD/EMTDC‐based simulation results.
Exploring the genre of telephone-based financial planning consultations
Authors: Moore Stephen H. , Knox John S. 
Published: January 2019

AbstractUntil relatively recently, financial planning typically involved investment advisers advising relatively wealthy and financially literate individuals about where to place their abundant disposable incomes. Today, many financial planners are focused on advising individuals with modest incomes and little understanding of finance how best to manage their financial affairs in anticipation of retirements that could last for decades. The domain of financial planning discourse, despite the profession’s remarkable growth, is virtually unexplored territory in terms of studies conducted using applied linguistic analytic tools. This paper sheds light on the social purpose of financial planning consultations and their realization through their generic structure. A dataset of 10 authentic recorded telephone-based financial planning consultations was established and analysed for generic moves usingHalliday and Hasan’s (1985)generic structure potential. Using the generic structure potential (GSP) as a basis for evaluating the achievement of intended social purpose, and identifying a problem in the move sequencing and the common omission of a key component, we suggest strategic discursive modifications that would improve outcomes for all stakeholders. Implications for professional and academic training are discussed.
Current research on CLIL and bilingual education in the Netherlands
Authors: Rumlich Dominik 
Published: January 2019

Abstract
The contribution at hand provides a discussion of the six articles in this special issue on bilingual education
and CLIL. It does so against the background of recent conceptual and empirical insights and the author’s perspective as an
“outsider from the inside”, i.e. as a visitor to Dutch CLIL schools, a CLIL researcher and part-time teacher at a German CLIL
school. The studies and resulting suggestions presented in this volume mark the way forward to a more efficient and effective CLIL
practice in the Netherlands and beyond. At the same time, it becomes clear that there are still many open questions and issues to
be looked into as CLIL is an intricate and challenging and endeavour for teachers, students, researchers and educational policy
alike.
Attitudinal factors and the intention to learn English in pre-vocational secondary bilingual and mainstream
education*
Authors: Denman Jenny , van Schooten Erik , de Graaff Rick 
Published: January 2019

Abstract
The effect of bilingual education (BE) on the attitude towards learning English of pupils in the first three years
of pre-vocational secondary education in the Netherlands (n = 488) was investigated. Contrary to several other
BE/CLIL studies, in the present study pupils choosing for a bilingual stream are not preselected based on their attitude or
motivation. Attitude was measured using the Model of Planned Behavior (MPB). The best-fitting attitude model was one in which the
perceived importance of learning English was a direct predictor of the Intention to make an effort, and not mediated by Affect. At
the start of BE in year 1 (age 12), attitudinal differences between bilingual and mainstream pupils were non-significant, but
after one or more years of a bilingual program, BE pupils scored significantly higher on four of the five MPB attitudinal
constructs. BE appears to positively influence the attitude towards learning English of junior vocational students.
Investigating audience orientation in courtroom communication
Authors: Chaemsaithong Krisda 
Published: January 2019

AbstractThis study presents an empirical study of audience orientation, investigating lawyers’ overt interpersonal negotiation with jurors. Drawing upon a corpus of the closing arguments of five high-profile American trials, the quantitative and qualitative analysis identifies the traces and degree of the jury’s presence through pronominal choices, questions, directives, references to shared knowledge and asides. Such relational practice does not merely “oil the wheels” of courtroom communication but also constitutes a key way to the meaning-making process in this phase of the trial. The findings attest to the centrality of relational work in accomplishing transactional goals in institutional discourses.
Half of Purposeful Baseline Sandbaggers Undetected by ImPACT’s Embedded Invalidity Indicators
Authors: Raab Courtney A , Peak Amy Sutton , Knoderer Chad 
Published: January 2019

AbstractObjectiveThe main objectives of this study were to determine how accurately the embedded invalidity indicators (EIIs) identify purposeful underperformers on the baseline Immediate Post-concussion Assessment and Cognitive Test (ImPACT); and to assess the effectiveness of each individual EII.MethodsA randomized controlled trial was conducted in which all participants completed a baseline ImPACT assessment. Participants were randomized into a control or purposeful underperformance (sandbagging) group. The primary outcomes measured were the number of participants identified as invalid (via any EII), as well as the ability of each individual EII to detect purposeful sandbagging. Additionally, participants mean raw composite scores and percentiles were evaluated.ResultsSeventy-seven participants completed the study (control n = 37, sandbag n = 40.) None of the participants in the control group, and 50% of the purposeful sandbaggers were identified as invalid via the current EIIs. Of the five EIIs, three were unable to identify more than 15% of purposeful sandbaggers. The best performing EIIs were Word Memory and Three Letters, identifying 40% and 35% of purposeful sandbaggers, respectively. Sixty- five percent of the purposeful sandbaggers had at least one composite score ≤1st percentile. Using a composite score ≤1st percentile as potential marker of invalidity would have accurately identified more purposeful sandbaggers than all existing EIIs combined.ConclusionHalf of purposeful sandbaggers were not identified by ImPACT’s current EIIs. Multiple EIIs were only able to identify &lt;15% of purposeful underperformers, suggesting that reevaluation and/or recalibration of EII cutoffs may be appropriate.