bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neue Versuchshalle des Instituts für Stahlbau der RWTH Aachen University
Authors: Kuhnhenne Markus , Mehrtens Peter , Schaffrath Simon , Karbig Nico , Feldmann Markus 
Published: October 2024

AbstractAls gewachsene Institution mit unterschiedlichen Forschungsfeldern hat das Institut für Stahlbau der RWTH Aachen einen hohen Bedarf an experimentellen Versuchseinrichtungen. Daher wird seit 2023 eine neue Versuchshalle in unmittelbarer Nähe zur bereits bestehenden Forschungsinfrastruktur errichtet. Dabei wurde die Gebäudehülle des Bauwerks genutzt, um vielfältige Möglichkeiten des Metallleichtbaus mit innovativen Konstruktionen umzusetzen. Zusätzlich können Teile der Gebäudehülle in zukünftige Forschungsprojekte als Reallabor eingebunden werden. Der Synergieeffekt von der Erstellung von Forschungsflächen in Kombination mit der Gebäudestruktur als reales Forschungsobjekt ermöglicht eine Ausweitung des Forschungsspektrums am Institut für Stahlbau der RWTH Aachen. Bereits während der Planungsphase wurde die einzigartige Möglichkeit in Anspruch genommen, das Bauprojekt mit innovativen Digitalisierungswerkzeugen zu begleiten. Mit der Erfassung und Vermessung des Neubaus im laufenden Bauprozess über einen 3D‐Laserscan und Fotogrammetrie per Drohne konnten die tatsächlichen Gebäudestrukturen digital nachgebildet werden. Diese Modelle werden für die Montage von Teilen der Fassade in ein Mixed‐Reality‐System integriert, was eine Montage der Aluminiumkassetten mit virtueller Anleitung ermöglicht. Sowohl Bau als auch Nutzung des Hallenneubaus erweitern damit die zukünftigen Forschungsmöglichkeiten am Institut für Stahlbau der RWTH Aachen.
Association of Major Histocompatibility Complex Polymorphism With Acute Phase Response in Broiler Chicken
Authors: Vatankhah Afra , Nikbakht Brujeni Gholamreza , Esmailnejad Atefeh 
Published: October 2024

ABSTRACTBackgroundStress associated with changes in host immunity occurs in response to altered environmental conditions, endogenous imbalances, infectious agents and harmful stimuli. The importance of genetic diversity in chickens has increased due to individual immune differences towards resistance and susceptibility to various stimuli.ObjectivesThis study aimed to investigate the association of major histocompatibility complex (MHC) polymorphism with acute phase response (APR) in Ross 308 broiler chickens.MethodsThe allelic diversity of the LEI0258 microsatellite marker was determined in 120 Ross broilers. In addition, acute phase proteins (APPs), including serum amyloid A (SAA) and alpha‐1‐acid glycoprotein (AGP), were analysed as markers of the APR. Furthermore, leukocyte count and the heterophil/lymphocyte ratio (H/L ratio) were examined. The antibody response to the Newcastle disease vaccine (NDV) was also measured to assess humoral mediated immunity. Lastly, the correlation between immune responses and MHC alleles was investigated to identify the most effective alleles in a stress‐related situation.ResultsA total of six alleles, ranging from 195 to 448 bp, were identified. Association study revealed a significant influence of MHC alleles on APPs in Ross population (p < 0.05). Notably, Allele 448 had a significant correlation with SAA concentration and the H/L ratio. Allele 207 displayed a positive association with AGP concentration, whereas Allele 195 showed a negative association. Furthermore, a significant association was observed between Allele 448 and basopenia, as well as between Allele 195 and monocytosis.ConclusionsResults confirmed the significance of MHC as a candidate gene marker for immune responses, which supports its use for vaccine design, genetic improvement of disease‐resistant traits and resource conservation in commercial broiler chickens.
Morphometric and Molecular Characterization of Fasciola spp. in Livestock From Northwestern Provinces of Iran
Authors: Galavani Hossein , Raeghi Saber , Karamian Mehdi , Torabi Negin , Haniloo Ali 
Published: October 2024

ABSTRACTBackgroundLiver flukes from the genus Fasciola are the causative agents for human and livestock fascioliasis. Accurate identification of Fasciola spp. is essential to understanding the epidemiology of fascioliasis. This study aimed to determine the morphometric and molecular characterization of Fasciola spp. in livestock from Northwestern provinces of Iran.MethodsFive hundred adult Fasciola flukes were obtained from different definitive hosts (cattle, sheep, goats, and buffaloes) in four local abattoirs in the northwestern provinces of Iran (West‐Azerbaijan, East‐Azerbaijan, Ardabil, and Zanjan) from September 2021 to August 2022. All samples were examined by morphometric criteria; then, 49 samples were identified using PCR‐RFLP based on ITS1 region and 23 sequence of isolates analyzed by cox1 marker. PCR‐RFLP methods compared morphometric results, and cox1 gene sequences were used to confirm PCR‐RFLP results and phylogenetic analysis.ResultsThe differences between the body length, body width, cephalic cone length, cephalic cone width, body area, and distance between the ventral sucker and posterior end of the body in two species were significant (p < 0.05). Based on the morphometric criteria, 139 samples (27.8%) were identified as Fasciola gigantica and 361 (72.2%) as Fasciola hepatica. Similarly, PCR‐RFLP analysis of ITS1 region confirmed morphometric results. No hybrid forms of Fasciola were detected. Partial sequences of cox1 showed 13 variable sites with eight haplotypes in F. hepatica and 12 variable sites with five haplotypes in F. gigantica.ConclusionBased on the results of this study, the PCR‐RFLP method can be used to confirm the morphological method of Fasciola species, but it is insufficient to study their genetic diversity. Also, sequences of cox1 results of the present study showed that F. hepatica and F. gigantica species in the Northern provinces of Iran have different genetic structures and haplotypes.
A Case Report on Alveolar Rhabdomyosarcoma in an Indigenous Dog
Authors: Akter Farjana , Rahman Md. Zillur , Rahman Mohammad Mahbubur , Nandita Bristy Dhar , Shikder Md. Foisal , Shihab Md. Piar Rahaman , Pallab Monoar Sayeed 
Published: October 2024

ABSTRACTA 12 years‐old, male indigenous dog was presented to Shahedul Alam Qaderi Teaching Veterinary Hospital (SAQTVH) in Chattogram, Bangladesh with a large tumour on its right front leg. The histopathological findings of the tumour were highly suggestive of an alveolar rhabdomyosarcoma (ARMS). The tumour was surgically removed from the dog. While there had been no recurrence for 5 months, the patient died 5 months post‐operatively. The cause of the death and presence of metastasis could not be confirmed as follow‐up investigations were declined by the owner. A histopathological study showed poorly differentiated neoplastic mononuclear cells forming nests in an alveolar pattern. Despite that the limited resources prevented myogenin staining for diagnostic confirmation, the well‐contained, defined appearance of the tumour supports the diagnosis of ARMS. This report highlights the challenges in diagnosing and treating ARMS in indigenous dogs and emphasizes the need for further research and diagnostic markers to improve detection and management.
Using Machine Learning for Systematic Literature Review Case in Point: Agile Software Development
Authors: David Itzik , Gelbard Roy 
Published: October 2024

ABSTRACTSystematic literature reviews (SLRs) are essential for researchers to keep up with past and recent research in their domains. However, the rapid growth in knowledge creation and the rising number of publications have made this task increasingly complex and challenging. Moreover, most systematic literature reviews are performed manually, which requires significant effort and creates potential bias. The risk of bias is particularly relevant in the data synthesis task, where researchers interpret each study's evidence and summarize the results. This study uses an experimental approach to explore using machine learning (ML) techniques in the SLR process. Specifically, this study replicates a study that manually performed sentiment analysis for the data synthesis step to determine the polarity (negative or positive) of evidence extracted from studies in the field of agile methodology. This study employs a lexicon‐based approach to sentiment analysis and achieves an accuracy rate of approximately 86.5% in identifying study evidence polarity.
Exploring unsteady radiative nanofluid dynamics: Thomson–Troian wall slip effects on a stretching rotating disk
Authors: Hussain Mazhar , Qayyum Mubashir , Rasool Mudassar 
Published: October 2024

AbstractFluid flow over rotating disk possesses many potential application in many engineering, biological, electrical, and chemical. Along with nanoparticles flow become more enriched in terms of chemical and physical properties. This study investigates the laminar, unsteady, incompressible flow of a water‐based nanofluid above a rotating, stretchable disk. The nanofluid consists of three distinct nanoparticles (magnetite), (copper), and (silver), under the influence of radiation. The behavior of the nanofluid is modeled using the Tiwari and Das model with generalized slip on the disk surface. The new facet of study is to examines the effects of different parameters including stretching, slip, radiation, skin friction, and Nusselt numbers on the flow dynamics. The fluid motion is driven by the rotation and stretching of the disk. Through appropriate similarity transformations, the governing partial differential equations for the flow and thermal transport processes are transformed into a set of coupled ordinary differential equations. These equations are then numerically solved using bvp4c method in MATLAB. The results indicate that velocities in both the radial and axial directions increase with rising stretching parameters, due which skin friction coefficient mount by . And, Nusselt number of fluid surge by increasing volume fraction of , , nanoparticles respectively. Additionally, the temperature increases with increment in the radiation parameter . An increase in the slip parameter's value results in a reduction in both radial and axial velocities.
Supracostal ultrasound guided approach percutaneous nephrolithotomy (SUGA-PNL) versus retrograde intrarenal surgery for large volume isolated upper calyceal stones: a prospective randomized analysis
Authors: Assem Ahmed , Abdalla Ahmed , Elzoheiry Mohamed , Elaziz Islam Nasser Abd , Amr Hesham , Bakr Heba , Rammah Ahmed M 
Published: October 2024

AbstractTo assess outcomes of supracostal ultrasound guided approach percutaneous nephrolithotomy (SUGA-PNL) and retrograde intrarenal surgery (RIRS) in isolated large volume upper calyceal stones (UCS). This was a prospective randomized study including patients with isolated UCS > 20mm. The patients were randomized into two groups: group (P) (SUGA-PNL) and group (R) (RIRS). Patients’ demographics, stones characteristics, operative, and postoperative outcomes essentially the stone free rate (SFR) and complications rate were documented. The stone clearance was defined as no fragments or residual fragments less than 2mm in the one month non contrast CT scan follow up. Eighty-nine patients opted to undergo the procedure according to the preoperative randomization. Four patients, 2 patients from each group, lost to follow up and other 2 patients were excluded from group (R) due to a tight ureter. Both groups were comparable as regards the preoperative demographics and stone characteristics. There were statistically significant differences regarding total operative time, the change in hemoglobin level, and postoperative pain score (P: 0.024, 0.010 and 0.032 respectively). The SFR was 88.1% in group (P) compared to 73.2% in group (R) (P: 0.019). Moreover, it did not differ significantly between both groups regarding the intraoperative and postoperative complications. No visceral and thoracic injuries were documented in group (P). On other side, 6 patients (14.6%) from group (R) had different grades of ureteral injury during access sheath placement. SUGA-PNL is a safe and effective treatment modality for UCS > 20mm with a higher SFR than RIRS.
Associations between academic achievement and internalizing disorders in Swedish students aged 16 years between 1990 and 2018
Authors: Högberg Björn , Strandh Mattias , Petersen Solveig , Nilsson Karina 
Published: October 2024

Abstract
Background
Rising rates of internalizing disorders and rising rates of school failure among adolescents are growing concerns. Despite the strong association between academic achievement and internalizing disorders, possible links between these two trends have not been investigated. Thus, the aim of this study was to investigate the development of the cross-sectional associations between academic achievement and internalizing disorders in Swedish students aged 16 years between 1990 and 2018.

Methods
Register data on specialist psychiatric care and prescriptions of psycholeptic and psychotropic drugs were linked to data on students’ school grades in the last year of compulsory school. The total sample size was 3,089,674 students. Logistic regression models with internalizing disorders as the dependent variable, and graduation year and academic achievement as independent variables, were estimated.

Results
Throughout the period, there was a strong negative association between academic achievement and internalizing disorders. Low-achieving students had by far the highest risks of internalizing disorders. In absolute terms, the increase in internalizing disorders was clearly largest for low-achieving students. The relative risks for low-achieving compared to higher achieving students increased between 1990 and 2010 and declined after 2010.

Conclusions
This study found consistently large, and at least until 2010 growing, achievement-related inequalities in internalizing disorders among Swedish adolescents between 1990 and 2018, with the lowest achieving students having disproportionally high risks. The increasingly pronounced concentration of internalizing disorders in the lowest rungs of the achievement distribution suggests that preventive interventions should focus on supporting this doubly disadvantaged group of students.
Beyond endocrine resistance: estrogen receptor (ESR1) activating mutations mediate chemotherapy resistance through the JNK/c-Jun MDR1 pathway in breast cancer
Authors: Taya Marwa , Merenbakh-Lamin Keren , Zubkov Asia , Honig Zohar , Kurolap Alina , Mayer Ori , Shomron Noam , Wolf Ido , Rubinek Tami 
Published: October 2024

Abstract

Purpose
All patients with metastatic breast cancer (MBC) expressing estrogen receptor-α (ESR1) will eventually develop resistance to endocrine therapies. In up to 40% of patients, this resistance is caused by activating mutations in the ligand-binding domain (LBD) of ESR1. Accumulating clinical evidence indicate adverse outcomes for these patients, beyond that expected by resistance to endocrine therapy. Here we aimed to study the role of ESR1 mutations in conferring chemoresistance in BC cells.

Methods
MCF-7 cells harboring Y537S and D538G ESR1 mutations (mut-ER) were employed to study the response to chemotherapy drugs, paclitaxel and doxorubicin, using viability and apoptotic assay in vitro, and tumor growth in vivo. JNK/c-Jun/MDR1 pathway was studied using qRT-PCR, western-blot, gene-reporter and ChIP assays. MDR1 expression was analyzed in clinical samples using IHC.

Results
Cell harboring ESR1 mutations displayed relative chemoresistance compared to WT-ER, evidenced by higher viability and reduced apoptosis as well as resistance to paclitaxel in vivo. To elucidate the underlying mechanism, MDR1 expression was examined and elevated levels were observed in mut-ER cells, and in clinical BC samples. MDR1 is regulated by the c-Jun pathway, and we showed high correlation between these two genes in BC using TCGA databases. Accordingly, we detected higher JNK/c-Jun expression and activity in ESR1-mutated cells, as well as increased occupancy of c-Jun in MDR1 promoter. Importantly, JNK inhibition decreased MDR1 expression and restored sensitivity to chemotherapy.

Conclusions
Taken together, these data indicate that ESR1 mutations confer chemoresistance through activation of the JNK/MDR1 axis. These finding suggest a novel treatment option for BC tumors expressing ESR1 mutations.
Are Digital Tools More Often Implemented in High-Quality Lessons?—Profiles of Instructional Quality and the Use of Digital Tools in Biology and Mathematics Lessons
Authors: Meuleners Julia S. , Lindermayer Christian , Traub Dagmar , Aufleger Monika , Rutkowski Annemarie , Kosiol Timo , Reith Sabrina , Arvaneh Begüm , Bannert Maria , Ufer Stefan , Neuhaus Birgit J. 
Published: October 2024

Abstract The potential contribution of digital tools to quality instruction is a widely debated issue in STEM education. As a first step to investigate this potential, it is necessary to understand how instructional quality and digital tool use are interrelated. Although previous research generally hinted that instructional quality and the use of digital tools are related, it is unclear how these relations are specific to different STEM subjects. Addressing this research gap, we compared the association between instructional quality and the use of digital tools in biology (Study 1) and mathematics lessons (Study 2) based on the questionnaires answered by N = 2,396 eight-grade students at German secondary schools. On the basis of Latent Profile Analyses of instructional quality features considering both their class-level and their within-class variability, the use of digital tools was compared for the profiles of instructional quality identified for biology and mathematics lessons. Study 1 showed, that the three profiles in biology significantly differed in their use of digital tools, whereas this was not the case with the four profiles identified in mathematics (Study 2). In biology, digital tools had been more often implemented in high-quality than in low-quality lessons. But there was no such difference in mathematics. It was conspicuous that students in biology lessons reported overall more digital tool use than in mathematics. Despite several similarities between STEM subjects, the results suggest that a subject-specific perspective on instructional quality and the use of digital tools is beneficial for a more nuanced approach to teacher training.
Users’ self-description on social media: a methodology to integrate labels and textual information
Authors: Ricciardi Riccardo 
Published: October 2024

AbstractTo analyze how groups of people self-describe on social media, existing studies separately or partly exploited labels and textual self-descriptions. In this paper, we leveraged both sources of information about the users in an integrated procedure, by training a language model on a sample of text documents with balanced characteristics, and then, by using a list of both domain-specific and statistically relevant words as a guide, similarities between word and document representations were explored to analyze group differences in self-describing. Eventually, a bootstrap procedure was employed to assess the reliability of the results. The methodology proposed was applied on data from StockTwits platform, where people write a bio and declare their experience, approach, and primary holding period in trading. We found that groups of traders differ in semantics. In addition, the relationship between the approach in trading and the holding period still holds in self-descriptions, whereas the experience transversely influences bio writing, with professionals using words strictly specific to the domain of stock trading.
Removal of formaldehyde from indoor air by potted Sansevieria trifasciata plants: dynamic influence of physiological traits on the process
Authors: Li Jian , Chen Silan , Zhong Jiaochan , Lin Shujie , Pang Shifan , Tu Qianying , Agranovski Igor 
Published: October 2024

AbstractPlant-based removal of indoor formaldehyde is a widely studied method, yet little is known about the dynamic changes in this process. In this study, potted Sansevieria trifasciata Prain plants were exposed to 5-ppm formaldehyde gas concentration for 7 days. The results showed that formaldehyde exposure led to plant stress, affected photosynthesis, and damaged membrane lipids, as evidenced by a decrease in chlorophyll content, an increase in Chl a/b ratio and malondialdehyde content. However, the formaldehyde removal ability of the plants increased over the first 5 days, peaking at 18.02 mg h−1 kg−1 dry weight on the 5th day. This trend was correlated with changes in various indicators in the plant roots, including phytohormone and antioxidant enzymes. Notably, catalase activity in the roots behaved differently from other indicators. The indicators in the leaves showed turning points around the 3rd day due to the direct exposure of the leaves to formaldehyde. The relative abundance of endophytes indicated an increase in plant growth-promoting bacteria, which helped the plant cope with formaldehyde stress. The study suggests that under formaldehyde stress, plants manage active oxygen content by increasing phytohormones and regulating redox reactions. This enhances their tolerances to formaldehyde, thereby improving their ability to remove formaldehyde and aiding recovery after formaldehyde exposure.
Graphical abstract
Heart Rate Variability and Cerebral Autoregulation in Patients with Traumatic Brain Injury with Paroxysmal Sympathetic Hyperactivity Syndrome
Authors: Burzyńska Małgorzata , Woźniak Jowita , Urbański Piotr , Kędziora Jarosław , Załuski Rafał , Goździk Waldemar , Uryga Agnieszka 
Published: October 2024

Abstract
Background
Severe traumatic brain injury (TBI) can lead to transient changes in autonomic nervous system (ANS) functioning and development of paroxysmal sympathetic hyperactivity (PSH) syndrome. Clinical manifestation of ANS disorders may be obscured by therapeutic interventions in TBI. This study aims to analyze ANS metrics and cerebral autoregulation in patients with PSH syndrome to determine their significance in early prognostication.

Methods
This single-center retrospective study investigated the relationship between changes in ANS metrics, cerebral autoregulation, and PSH syndrome. Arterial blood pressure and intracranial pressure signals were monitored for 5 days post TBI. ANS metrics included time and frequency domain heart rate variability (HRV) metrics. Cerebral autoregulation was assessed using the pressure reactivity index.

Results
Sixty-six patients with severe TBI (median age 33 [interquartile range 26–50] years) were analyzed, and PSH was confirmed in nine cases. Impairment of cerebral autoregulation was observed in 67% of patients with PSH and 72% without the syndrome. Patients with PSH had higher HRV in the low-frequency range (LF; 253 ± 178 vs. 176 ± 227 ms2; p = 0.035) and lower heart rates (HRs; 70 ± 7 vs. 78 ± 19 bpm; p = 0.027) compared to those without PSH. A receiver operating characteristic curve analysis indicated that HR (area under the curve (AUC) = 0.73, p = 0.006) and HRV in the LF (AUC = 0.70, p = 0.009) are moderate predictors of PSH. In the multiple logistic regression model for PSH, diffuse axonal trauma (odds ratio (OR) = 10.82, 95% confidence interval (CI) = 1.70–68.98, p = 0.012) and HR (OR = 0.91, 95% CI 0.84–0.98, p = 0.021) were significant factors.

Conclusions
Elevated HRV in the LF and decreased HR may serve as early predictors of PSH syndrome development, particularly in patients with diffuse axonal trauma. Further research is needed to investigate the utility of the cerebral autoregulation–ANS relationship in PSH prognostication.