bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Development of Light‐Mediated Carboxylation Using CO2 as the Feedstock
Authors: Hou Jing , Li Jie‐Sheng , Wu Jie 
Published: May 2018

AbstractCO2 is an attractive renewable C1 feedstock owing to its abundance, low cost, and nontoxicity. Developing new catalytic protocols for CO2 utilization is of great importance. With the development of photoredox catalysis over the past decades, light‐driven CO2 fixation has attracted significant attention. This Review will focus on recent development of light‐promoted carboxylation utilizing CO2 as a C1 source to synthesize value‐added chemicals in the area of organic synthesis.
Aerobic oxidation of styrene in functional reactors and computational fluid dynamics simulation
Authors: Zhang Lingling , Liu Chengzhi , He Xiangpo , Zhang Feng , Zhang Zhibing 
Published: May 2018

AbstractA possible reaction mechanism was proposed, and the kinetic relationships between rate of styrene conversion (or product generation) and condition parameters were established for the aerobic oxidation of styrene by using isobutyraldehyde as coreductant and cobalt(II) acetate as catalyst. The effects of aldehyde amount, catalyst amount, and volume ratio of solvent to styrene on the total yield of products (styrene oxide and benzaldehyde) were evaluated by the response surface methodology systematically. Relative mathematical models were presented to reveal the optimal reaction conditions, which were used for further scale‐up experiments in bubbling column reactor and airlift loop reactor. The 2 reactors had different results due to structural characteristics. Larger gas holdup and longer gas residence time led to higher styrene conversion in the bubbling column reactor, whereas faster and regular liquid circulation resulted in higher styrene oxide selectivity in the airlift loop reactor due to better dispersion of solid catalyst. Furthermore, the different performances of the 2 reactors were explained with computational fluid dynamics by considering turbulence intensity, axial velocity distribution, gas holdup, and volumetric mass transfer coefficient.
Expression of Regeneration‐Associated Proteins in Primary Sensory Neurons and Regenerating Axons After Nerve Injury—An Overview
Authors: Dubový Petr , Klusáková Ilona , Hradilová‐Svíženská Ivana , Joukal Marek 
Published: May 2018

ABSTRACTPeripheral nerve injury results in profound alterations of the affected neurons resulting from the interplay between intrinsic and extrinsic molecular events. Restarting the neuronal regenerative program is an important prerequisite for functional recovery of the injured peripheral nerve. The primary sensory neurons with their cell bodies in the dorsal root ganglia provide a useful in vivo and in vitro model for studying the mechanisms that regulate intrinsic neuronal regeneration capacity following axotomy. These studies frequently need to indicate the regenerative status of the corresponding neurons. We summarize the critical issues regarding immunohistochemical detection of several regeneration‐associated proteins as markers for the initiation of the regeneration program in rat primary sensory neurons and indicators of axon regeneration in the peripheral nerves. This overview also includes our own results of GAP43 and SCG10 expression in different DRG neurons following double immunostaining with molecular markers of neuronal subpopulations (NF200, CGRP, and IB4) as well as transcription factors (ATF3 and activated STAT3) following unilateral sciatic nerve injury. Anat Rec, 301:1618–1627, 2018. © 2018 Wiley Periodicals, Inc.
Comparative Evaluation of Chitosan Nerve Guides with Regular or Increased Bendability for Acute and Delayed Peripheral Nerve Repair: A Comprehensive Comparison with Autologous Nerve Grafts and Muscle‐in‐Vein Grafts
Authors: Stößel Maria , Wildhagen Vivien M. , Helmecke Olaf , Metzen Jennifer , Pfund Charlotte B. , Freier Thomas , Haastert‐Talini Kirsten 
Published: May 2018

ABSTRACTReconstruction of joint‐crossing digital nerves requires the application of nerve guides with a much higher flexibility than used for peripheral nerve repair along larger bones. Nevertheless, collapse‐resistance should be preserved to avoid secondary damage to the regrowing nerve tissue. In recent years, we presented chitosan nerve guides (CNGs) to be highly supportive for the regeneration of critical gap length peripheral nerve defects in the rat. Now, we evidently increased the bendability of regular CNGs (regCNGs) by developing a wavy wall structure, that is, corrugated CNGs (corrCNGs). In a comprehensive in vivo study, we compared both types of CNGs with clinical gold standard autologous nerve grafts (ANGs) and muscle‐in‐vein grafts (MVGs) that have recently been highlighted in the literature as a suitable alternative to ANGs. We reconstructed rat sciatic nerves over a critical gap length of 15 mm either immediately upon transection or after a delay period of 45 days. Electrodiagnostic measurements were applied to monitor functional motor recovery at 60, 90, 120, and 150 (only delayed repair) days postreconstruction. Upon explanation, tube properties were analyzed. Furthermore, distal nerve ends were evaluated using histomorphometry, while connective tissue specimens were subjected to immunohistological stainings. After 120 days (acute repair) or 150 days (delayed repair), respectively, compression–stability of regCNGs was slightly increased while it remained stable in corrCNGs. In both substudies, regCNGs and corrCNGs supported functional recovery of distal plantar muscles in a similar way and to a greater extent when compared with MVGs, while ANGs demonstrated the best support of regeneration. Anat Rec, 301:1697–1713, 2018. © 2018 Wiley Periodicals, Inc.
Association of Inflammatory Bowel Disease and Acute Anterior Uveitis, but Not Psoriasis, With Disease Duration in Patients With Axial Spondyloarthritis
Authors: Varkas Gaëlle , Vastesaeger Nathan , Cypers Heleen , Colman Roos , Renson Thomas , Praet Liesbet Van , Carron Philippe , Raeman Frank , Devinck Mieke , Gyselbrecht Lieve , Corluy Luc , Piette Yves , Lenaerts Jan , Thevissen Kristof , Vanneuville Benedicte , Bosch Filip Van den , Elewaut Dirk 
Published: May 2018

ObjectiveTo determine the link between extraarticular manifestations (EAMs) and baseline characteristics in patients with axial spondyloarthritis (SpA), and to define their potentially differential prognostic value in 2 large, independent Belgian axial SpA cohorts with distinct recruitment periods.MethodsInformation on demographic and clinical characteristics and extraarticular manifestations (EAMs) was obtained from patients with axial SpA originating from the (Be)Giant (Belgian Inflammatory Arthritis and Spondylitis) cohort, which includes consecutive axial SpA patients whose data have been collected since 2010, and from the ASPECT (Ankylosing Spondylitis Patients Epidemiological Cross‐sectional Trial) cohort, a Belgian registry of cross‐sectional data collected between February 2004 and February 2005 from consecutive patients with ankylosing spondylitis (AS) or probable AS.ResultsAmong the 1,250 Belgian patients studied, disease duration was associated with risk of developing inflammatory bowel disease (IBD), with an increase in risk by 20% per 10 years of disease duration (relative risk [RR] 1.2, P = 0.026), and associated with risk of developing acute anterior uveitis, with an increase in risk by 30% per 10 years of disease duration (RR 1.3, P < 0.001). In the subgroup of 171 newly diagnosed patients with prospective follow‐up data, higher mean C‐reactive protein levels over time were demonstrated in those with acute anterior uveitis or IBD compared to those without EAMs or those with psoriasis alone (each P = 0.01).ConclusionThe risk of developing acute anterior uveitis or IBD, but not psoriasis, in patients with axial SpA seems to increase with disease duration and appears to be linked to a higher cumulative exposure to inflammation, thus providing a possible explanation for the differential structural progression observed in those with axial SpA.
Similarities between the responses to ANT‐DBS and prior VNS in refractory epilepsy
Authors: Kulju Toni , Haapasalo Joonas , Lehtimäki Kai , Rainesalo Sirpa , Peltola Jukka 
Published: May 2018

AbstractObjectivesNeurostimulation has offered new treatment options in refractory epilepsy, first with vagus nerve stimulation (VNS) and more recently with deep brain stimulation (DBS). There is a lack of previous detailed data assessing the relationship between VNS and ANT‐DBS. The aim of this study was to investigate the potential correlation between therapeutic responses to VNS and ANT‐DBS.Materials and MethodsA total of 11 patients with previous VNS therapy underwent ANT‐DBS implantation. Monthly seizure counts starting from baseline before VNS extending to long‐term DBS treatment were analyzed. The reasons for VNS discontinuation were assessed.ResultsAltogether in 10 of 11 patients, the response to VNS seemed to be similar to the response to DBS therapy. Progressive response to VNS was likely to correlate with a progressive response to DBS in three of three patients. Partial response to VNS was associated with a fluctuating response pattern to DBS in two patients. Five of six nonresponders to VNS were also nonresponders to DBS. One of the VNS nonresponders obtained progressive response to DBS.ConclusionsThis is the first study to evaluate in detail the effect of both VNS and ANT‐DBS in refractory epilepsy patients. There is a putative association between VNS and DBS responses suggesting the need for further studies.
Prediction of vascular abnormalities on CT angiography in patients with acute headache
Authors: Alons Imanda M. E. , Goudsmit Ben F. J. , Jellema Korné , van Walderveen Marianne A. A. , Wermer Marieke J. H. , Algra Ale 
Published: May 2018

AbstractObjectivesPatients with acute headache increasingly undergo CT‐angiography (CTA) to evaluate underlying vascular causes. The aim of this study is to determine clinical and non‐contrast CT (NCCT) criteria to select patients who might benefit from CTA.MethodsWe retrospectively included patients with acute headache who presented to the emergency department of an academic medical center and large regional teaching hospital and underwent NCCT and CTA. We identified factors that increased the probability of finding a vascular abnormality on CTA, performed multivariable regression analyses and determined discrimination with the c‐statistic.ResultsA total of 384 patients underwent NCCT and CTA due to acute headache. NCCT was abnormal in 194 patients. Among these, we found abnormalities in 116 cases of which 99 aneurysms. In the remaining 190 with normal NCCT we found abnormalities in 12 cases; four unruptured aneurysms, three cerebral venous thrombosis’, two reversible cerebral vasoconstriction syndromes, two cervical arterial dissections and one cerebellar infarction. In multivariable analysis abnormal NCCT, lowered consciousness and presentation within 6 hr of headache onset were independently associated with abnormal CTA. The c‐statistic of abnormal NCCT alone was 0.80 (95% CI: 0.75–0.80), that also including the other two variables was 0.84 (95% CI: 0.80–0.88). If NCCT was normal no other factors could help identify patients at risk for abnormalities.ConclusionsIn patients with acute headache abnormal NCCT is the strongest predictor of a vascular abnormality on CTA. If NCCT is normal no other predictors increase the probability of finding an abnormality on CTA and diagnostic yield is low.
Angiotensin II enhances the acetylation and release of HMGB1 in RAW264.7 macrophage
Authors: Zhou Shanshan , Lu Hongxiang , Chen Rong , Tian Yu , Jiang YuanYuan , Zhang Shiqing , Ni Daobing , Su Zhaoliang , Shao Xiaoyi 
Published: May 2018

AbstractThe high‐mobility group box‐1 (HMGB1), as a highly conserved ubiquitous DNA‐binding protein, has been widely studied in various diseases, including inflammation and tumor; however, fewer studies were focused on the mechanisms controlling HMGB1 release compared with the function of HMGB1. Previous studies have proven that ANG II can act as a pro‐inflammatory cytokine, both of HMGB1 and ANG II were significantly upregulated in autoimmune diseases; however, the exact role of ANG II in regulating HMGB1 release have not been shown. The present study was to define the effects of ANG II on macrophages and the possible mechanisms in controlling HMGB1 release. Our results showed that ANG II can induce M1 macrophage polarization through upregulated the expression of HMGB1 and caused acetylation of HMGB1 and release via its dissociation from SIRT1, which in a positive feedback upregulates ANG II. Subsequently, HMGB1 inhibitors can reduce the ANG II‐elicited polarize of macrophage. Meanwhile, we show that JAK/STAT pathways play an essential role in ANG II‐induced HMGB1 nuclear translocation, JAK/STAT specific inhibitors can inhibit ANG II‐induced HMGB1 expression. Taken together, our results provide a novel evidence that HMGB1 play a critical role in ANG II mediated macrophage polarization, and we suggest that ANG II mediated HMGB1 release via dissociation from SIRT1, induce hyperacetylation of HMGB1, thus for subsequent release, suggesting that the angiotensin II receptor antagonist is a potential drug target for inhibiting HMGB1 release in inflammation diseases.
Co‐occurrence of hypertrophic cardiomyopathy and juvenile myelomonocytic leukemia in a neonate with Noonan syndrome, leading to premature death
Authors: Tamura Akihiro , Uemura Suguru , Matsubara Kousaku , Kozuki Eru , Tanaka Toshikatsu , Nino Nanako , Yokoi Takehito , Saito Atsuro , Ishida Toshiaki , Hasegawa Daiichiro , Umeki Ikumi , Niihori Tetsuya , Nakazawa Yozo , Koike Kenichi , Aoki Yoko , Kosaka Yoshiyuki 
Published: May 2018

Key Clinical MessageWe report a case of a neonate with Noonan syndrome presenting with concurrent hypertrophic cardiomyopathy and juvenile myelomonocytic leukemia, which resulted in premature death. Cases with Noonan syndrome diagnosed during the neonatal period might not necessarily show mild clinical course, and premature death is a possible outcome to be considered.
Diagnostic exome sequencing identifies GLI2 haploinsufficiency and chromosome 20 uniparental disomy in a patient with developmental anomalies
Authors: Sajan Samin A. , Powis Zöe , Helbig Katherine L. , Nagakura Honey , Immken Ladonna , Tang Sha , Alcaraz Wendy A. 
Published: May 2018

Key Clinical MessageClinical diagnostic exome sequencing (DES) is currently infrequently used for detecting uniparental disomy (UPD). We present a patient with a dual diagnosis of GLI2 haploinsufficiency as well as UPD of chromosome 20, both identified through DES. We therefore recommend routine UPD analysis during DES to identify this genetic aberration.
In Situ Prepared Flexible 3D Polymer Film Photocatalyst for Highly Selective Solar Fuel Production from CO2
Authors: Yadav Rajesh K. , Kumar Abhishek , Yadav Dolly , Park No‐Joong , Kim Jae Young , Baeg Jin‐Ook 
Published: May 2018

AbstractThe front cover artwork for issue 9/2018 is provided by Prof. Jin‐Ook Baeg's artificial photosynthesis research group from Korea Research Institute of Chemical Technology (KRICT), Republic of Korea. The image shows a light harvesting 3D aromatic polymer (3DAP) derived from triptycene that can efficiently and selectively convert CO2 to formic acid. See the Full Paper itself at https://doi.org/10.1002/cctc.201701730.
Effects of Temperature on the Comproportionation of Metallic Copper and Cupric Ions to Cuprous Ions
Authors: Schmidt Ralf , Gaida Josef 
Published: May 2018

AbstractThe temperature dependence of the comproportionation reaction of metallic copper and cupric ions to cuprous ions was studied by means of conventional polarization experiments. The bulk concentration of cuprous ions was determined by means of Levich plots based on mass‐transport limitations at very small cathodic overpotentials. The corresponding temperature dependence revealed increasing concentration with increasing temperature. This effect could be ascribed to enthalpy and entropy contributions to the Gibbs free energy of the equilibrium between the copper ion species, which were obtained by Van't Hoff analysis of the equilibrium constant. Formation of cuprous ions from metallic copper and cupric ions was found to be endothermic, but slightly favored by entropy. The results provide insights into the temperature dependence of industrial plating electrolytes, which is of increasing importance for upcoming advanced packaging applications like tall copper pillars. This approach should be especially suitable to determine the effects of industrially relevant additives in complicated, multi‐component electrolytes in the future.
Porous Urchin‐like Co3O4 Microspheres as an Efficient Bifunctional Catalyst for Nonaqueous and Solid‐State Li−O2 Batteries
Authors: Liu Shengming , Zhang Wenqiang , Chen Ning , Sun Chunwen 
Published: May 2018

AbstractPorous urchin‐like Co3O4 microspheres consisting of nanowires (NWs) have been obtained through a hydrothermal synthesis. This unique porous structure not only increases the number of active sites for reactions, but also provides more storage space for the discharge product Li2O2. When used as a cathode catalyst for Li−O2 batteries with nonaqueous electrolyte, the cell exhibits a much higher initial specific discharge capacity of 9013.1 mA h g−1, better rate capability and cycling stability. Furthermore, rechargeable solid‐state Li−O2 cells were prepared with a hybrid solid electrolyte (HSE) membrane composed of inorganic Li7La3Zr2O12 particles and PVDF‐HFP both as electrolyte and separator, and Co3O4‐NWs microspheres used as a catalyst for the air electrode. The solid‐state Li−O2 cell with this catalyst shows a high initial specific capacity of 8000 mA h g−1, close to that of the cell with liquid electrolyte. It also shows a better stability with low polarization.
Nitrogen‐Doped Graphdiyne as High‐Capacity Electrode Materials for Both Lithium‐Ion and Sodium‐Ion Capacitors
Authors: Shen Xiangyan , Yang Ze , Wang Kun , Wang Ning , He Jianjiang , Du Huiping , Huang Changshui 
Published: May 2018

AbstractThe front cover artwork is provided by Dr. Changshui Huang and Xiangyan Shen, Qingdao Institute of Bioprocess Technology, Chinese Academy of Sciences (China). The image shows that nitrogen‐doped graphdiyne is applied as the anode for Li+ and Na+ capacitors. Read the full text of the Article at 10.1002/celc.201800300.
Impact of Conformational Effects on the Ring–Chain Equilibrium of Hydrogen‐Bonded Dinucleosides
Authors: Montoro‐García Carlos , Bilbao Nerea , Tsagri Iris M. , Zaccaria Francesco , Mayoral Maria J. , Fonseca Guerra Célia , González‐Rodríguez David 
Published: May 2018

AbstractSupramolecular ring‐versus‐chain equilibria are ubiquitous in biological and synthetic systems. Understanding the factors that decide whether a system will fall on one side or the other is crucial to the control of molecular self‐assembly. This work reports results with two kinds of dinucleoside monomers, in which the balance between closed cycles and open polymers is found to depend on subtle factors that rule conformational equilibria, such as steric hindrance, intramolecular interactions, or π‐conjugation pathways.
Relationships between cetuximab‐induced anaphylaxis and specific antibodies against allergen and tick‐transmitted infections
Authors: Namba Chika , Tohyama Mikiko , Murakami Masamoto , Yoshida Tadashi , Ugumori Tohru , Hato Naohito , Tano Tomoyuki , Hamakawa Hiroyuki , Kojima You , Nishina Tomohiro , Monden Nobuya , Fujita Hiromi , Sayama Koji 
Published: May 2018

AbstractBackgroundThe principal antigen responsible for cetuximab‐induced anaphylaxis is galactose‐α‐1,3‐galactose (α‐gal), expressed on the Fab portion of the monoclonal antibody. Recent studies have shown that cetuximab allergy is associated with a history of tick bite. We explored factors predicting cetuximab‐induced anaphylaxis, focusing on the relationship thereof to a history of tick bite.MethodsFifty‐two patients prescribed cetuximab at Ehime University Hospital or Shikoku Cancer Center were included in this study. We measured specific immunoglobulin E (IgE) levels targeting red meats, animal danders, and α‐gal using immunoCAP. Anti‐Rickettsia japonica antibody levels were assayed using an indirect immunoperoxidase test. Anticetuximab antibody was quantified by Western blotting and enzyme‐linked immunosorbent assay of serum samples.ResultsOf the 52 patients, five exhibited anaphylactic reactions to cetuximab that were not associated with specific IgEs against beef, pork, or animal dander. IgE against α‐gal was detected at class 1 in the sera of two of the five patients. Anticetuximab IgE was detected in four of 52 patients, only one of whom had anaphylaxis to cetuximab. Only two of the 52 patients had a history of a tick bite, one of whom had cetuximab‐induced anaphylaxis. The patient without anaphylaxis was positive for anti‐ R. japonica antibody.ConclusionsThe α‐gal‐specific IgE‐positivity can be used to identify those at risk of cetuximab‐induced anaphylaxis. The cutoff level should be set up the detection limit to predict cetuximab‐induced anaphylaxis, because the antibody levels are very low in our study.
The Impact of Indirect Corporate Social Performance Signals on Firm Value: Evidence from an Event Study
Authors: Luffarelli Jonathan , Awaysheh Amrou 
Published: May 2018

AbstractPrior research shows that signals sent by institutionalized third parties (i.e. indirect signals) about firms' corporate social performance (CSP) can impact firm value. However, the effects that different types of indirect CSP signals have on firm value have remained largely unexplored. Furthermore, managers often do not fully understand how to communicate CSP effectively. In this article, we operationalize CSP as a multidimensional construct and draw on signalling theory to examine how different types of indirect CSP signals impact firm value. The results of an event study show that institutionalized third parties can play an important role in delivering credible CSP‐related information to the market. Results also demonstrate that the valence (positivity vs. negativity) and content (the specific social domain) of indirect CSP signals are important predictors of the magnitude of market reactions, and that shareholders' responses to the valence and content of indirect CSP signals have substantially changed over time. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
How to Harvest Grotthuss Diffusion in Protic Ionic Liquid Electrolyte Systems
Authors: Ingenmey Johannes , Gehrke Sascha , Kirchner Barbara 
Published: May 2018

AbstractHydrogen is often regarded as fuel of the future, and there is an increasing demand for the development of anhydrous proton‐conducting electrolytes to enable fuel‐cell operation at elevated temperatures exceeding 120 °C. Much attention has been directed at protic ionic liquids as promising candidates, but in the search for highly conductive systems the possibility of designing Grotthuss diffusion‐enabled protic ionic liquids has been widely overlooked. Herein, the mechanics of proton‐transfer mechanism in the equimolar mixture of N‐methylimidazole and acetic acid was explored using ab initio molecular dynamics simulations. The ionicity of the system is approximated with good agreement to experiments. This system consists mostly of neutral species but exhibits a high ionic conductivity through Grotthuss‐like proton conduction. Chains of acetic‐acid molecules and other species participating in the proton‐transfer mechanisms resembling Grotthuss diffusion could be directly observed. Furthermore, based on these findings, a series of static quantum chemical calculations was conducted to investigate the effect of substituting the anion and cation with different functional groups. We predict whether a given combination of cation and anion will be a true ionic liquid or a molecular mixture and propose some systems as candidates for Grotthuss diffusion‐enabled protic ionic liquids.