bluuebunny/crossref_metadata_2025_split huggingface dataset:
From clinical appearance to accurate management in acute ischemic stroke patients: With the guidance of innovative traditional Chinese medicine diagnosis
Authors: Song Juexian , Xu Cuiyu , Zhang Jing , Gao Li 
Published: October 2019

AbstractObjectiveTo investigate the correlation between simplified classification and laboratory indicators in patients with acute ischemic stroke, also provide accurate evidences for simplified classification and guide clinical interventions and treatment.MethodsTwo hundred patients with acute ischemic stroke were classified into four types according to the characteristics of Traditional Chinese Medicine syndrome: phlegm‐heat syndrome, phlegm‐dampness syndrome, qi deficiency syndrome, and yin deficiency syndrome. The differences between the types of syndromes and the correlation between laboratory indicators and syndromes were analyzed.ResultsAmong the 200 patients with acute ischemic stroke, there were significant differences in the level of low‐density lipoprotein (LDL‐C) (p < .05) between patients with phlegm‐heat syndrome and other three types. There were significant differences in the levels of homocysteine (HCY) and fibrinogen (Fib) between patients with yin deficiency syndrome and other three types (p < .05). In addition, there were statistically significant differences in blood glucose (Glu), glycosylated hemoglobin (HBA1c), and total cholesterol (CHO) between phlegm‐heat syndrome and qi deficiency syndrome (p < .05). There were significant differences in the levels of Glu, HBA1c, D‐2 polymer (D‐D), and C‐reactive protein (CRP)s between patients with phlegm‐heat syndrome and phlegm‐dampness syndrome (p < .05). There were statistically significant differences in the levels of CRP and urea nitrogen between patients with yin deficiency syndrome and phlegm‐dampness syndrome and qi deficiency syndrome (p < .05).ConclusionsThe four‐type simplified classification of Integrated TCM and Western medicine in acute ischemic stroke has specific laboratory data to support. Simplified classification with TCM treatment and intervention of different patients improves the survival and treatment, which is an innovative, easy‐to‐master clinical diagnosis and treatment model.
Clinical applications of transcranial magnetic stimulation in bipolar disorder
Authors: Gold Alexandra K. , Ornelas Ana Claudia , Cirillo Patricia , Caldieraro Marco Antonio , Nardi Antonio Egidio , Nierenberg Andrew A. , Kinrys Gustavo 
Published: October 2019

AbstractBackgroundMany patients with bipolar disorder (BD) fail to experience benefit following traditional pharmacotherapy, necessitating alternative treatment options that will enable such patients to achieve remission. Transcranial magnetic stimulation (TMS) is a relatively new, noninvasive neuromodulation technique that involves the application of magnetic pulses on hyperactive or hypoactive cortical brain areas. We evaluated the existing literature on TMS as a treatment for BD across varied mood states.MethodsWe searched PubMed up to October 2018 for original data articles published in English that evaluated outcomes in a bipolar sample across depressive, manic, mixed, and maintenance phases of BD.ResultsClinical trials of TMS for BD particularly suggest the potential of repetitive TMS for reducing depressive symptoms. Studies of TMS for mania have yielded more mixed findings. Few studies have evaluated TMS in other phases of the bipolar illness. TMS is generally associated with mild side effects though, in a few studies, it has been shown to contribute to a manic switch in previously depressed bipolar patients.ConclusionsTranscranial magnetic stimulation is a promising approach for treating patients with BD who have failed to respond to pharmacological or psychosocial treatment. Future research should more clearly elucidate which TMS protocols may be most effective for a given bipolar patient.
Association between Lys198Asn polymorphism of endothelin‐1 gene and ischemic stroke: A meta‐analysis
Authors: Nepal Gaurav , Ojha Rajeev , Dulal Hari Prasad , Yadav Binod Kumar 
Published: October 2019

AbstractBackgroundEndothelin (ET)‐1 is a potent vasoconstrictor peptide produced by endothelial cells and associated with vascular dysfunction and cardiovascular disease. Lys198Asn is a single‐nucleotide polymorphism (SNP) of gene encoding ET‐1 (EDN1). It is hypothesized that it might have a role in altering ET‐1 and ultimately leading to vascular dysfunction and ischemic stroke. We therefore conducted a meta‐analysis to investigate the association between Lys198Asn polymorphism of EDN1 gene and susceptibility of ischemic stroke.MethodsThis meta‐analysis was conducted according to the guidance of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement. We searched PubMed, Google Scholar, Embase, Web of Science, J‐STAGE, and China National Knowledge Infrastructure (CNKI) for relevant studies. The association between Lys198Asn polymorphism and ischemic stroke susceptibility was evaluated by calculating the pooled ORs and 95% CIs.ResultsOur analysis included 1,291 cases and 2,513 controls. Meta‐analysis established a significant association between Lys198Asn SNP of EDN1 gene and ischemic stroke when assuming either recessive model (OR: 1.30; 95% CI: 1.02–1.65; p = .03; I2 = 41%) or dominant model (OR: 1.48; 95% CI: 1.24–1.76; p < .001; I2 = 61%). There was no evidence of publication bias in either of the recessive model (Egger test: p = .23; Begg test: p = .85) or dominant model (Egger test: p = .79; Begg test: p = .85). A subgroup analysis based on subtypes of ischemic stroke showed that Lys198Asn SNP was only associated with large vessel infarction but not with lacunar infarction caused by small vessel disease. A subgroup analysis based on ethnicity revealed that the Lys198Asn polymorphism of the EDN1 gene was associated with ischemic stroke only in Caucasians.ConclusionsThe present meta‐analysis suggests that Lys198Asn polymorphism of EDN1 gene is associated with an increased risk for ischemic stroke.
Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features
Authors: Ronchi Andrea , Cozzolino Immacolata , Montella Marco , Panarese Iacopo , Zito Marino Federica , Rossetti Sabrina , Chieffi Paolo , Accardo Marina , Facchini Gaetano , Franco Renato 
Published: October 2019

AbstractExtragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis from occult gonadal neoplasms. The actual observations suggest that EGGCTs represent a unique entity, so their biology and behavior are substantially different from gonadal counterparts. The diagnosis of EGGCTs is often challenging, and differential diagnosis is particularly wide. Nevertheless, a correct diagnosis is essential for the correct management of the patient. We summarize the state of art about EGGCTs, with particular emphasis on diagnosis and prognosis.
Chemotherapeutic perfusion of portal vein after tumor thrombectomy and hepatectomy benefits patients with advanced hepatocellular carcinoma: A propensity score‐matched survival analysis
Authors: Gao Yang , Wang Peng‐Xiang , Cheng Jian‐Wen , Sun Yun‐Fan , Hu Bo , Guo Wei , Zhou Kai‐Qian , Yin Yue , Li Yuan‐Cheng , Wang Jian , Huang Jun‐Feng , Qiu Shuang‐Jian , Zhou Jian , Fan Jia , Yang Xin‐Rong 
Published: October 2019

AbstractBackgroundPortal vein tumor thrombus (PVTT) is a common complication in hepatocellular carcinoma (HCC), signaling dismal outcomes. This study was conducted to evaluate the survival benefit of postoperative portal vein perfusion chemotherapy (PVC) in patients with HCC and PVTT.MethodsA retrospective review was conducted in 401 consecutive patients with HCC and PVTT who underwent hepatic resection between January 2009 and December 2015 and 67 patients received adjuvant postoperative PVC. A propensity score matching (PSM) was used to match patients with and without PVC at a ratio of 1:1.ResultsAfter PSM, the median time to recurrence (TTR) and overall survival (OS) were significantly longer in PVC group compared with control group (12.3 vs 5.8 months, P = .001; 19.0 vs 13.4 months, P = .037; respectively). At 1, 2, 3, and 5 years, the cumulative recurrence rates in PVC group were 48.1%, 86.5%, 92.3% ,96.2%, respectively, with OS rates of 63.8%, 37.9%, 24.4%, 18.3%, respectively; whereas cumulative recurrence rates of 76.6%, 91.5%, 94.3%, and 97.2%, respectively and OS rates of 55.4%, 23.0%, 12.4%, and 12.4%, respectively were recorded for the control group. In multivariate analysis, postoperative PVC emerged as a significant predictor for TTR (hazard ratio [HR], 0.523; P = .001) and OS (HR, 0.591; P = .010). PVC could reduce early recurrence (≤1 year) rate after surgical resection (40.3% vs 64.2%, P = .006) and clinical outcomes were further enhanced by adding sorafenib to postoperative PVC.ConclusionsCompared with surgical resection alone, postoperative adjuvant PVC treatment boosts survival and reduces early tumor recurrences in patients surgically treated for HCC and PVTT.
A five‐miRNA panel in plasma was identified for breast cancer diagnosis
Authors: Li Minghui , Zou Xuan , Xia Tiansong , Wang Tongshan , Liu Ping , Zhou Xin , Wang Shui , Zhu Wei 
Published: October 2019

AbstractBreast cancer (BC) is one of the most common cancers in females. Since early detection can bring prognosis benefit, discovery of novel noninvasive biomarkers for BC diagnosis is in urgent need. In this four‐phase study, we profiled miRNA expression in plasma samples from a total of 257 BC patients and 257 normal controls (NCs). Exiqon miRNA qPCR panel was used to select candidate miRNAs in the screening phase which were further analyzed using qRT‐PCR in the following training, testing and external validation phases. Finally, we identified five plasma miRNAs (let‐7b‐5p, miR‐122‐5p, miR‐146b‐5p, miR‐210‐3p and miR‐215‐5p) whose expression levels were significantly different between BC patients and NCs. A 5‐miRNA panel in plasma with high sensitivity and specificity was then constructed to detect BC. The areas under the receiver‐operating characteristic curves (AUCs) of the panel were 0.683, 0.966, 0.978 for the training, testing and external validation sets, respectively. Expression of the identified miRNAs was further analyzed among 32 pairs of BC tissue and the adjacent normal tissue samples as well as plasma‐derived exosome samples from 32 BC patients vs 32 NCs. Let‐7b‐5p was contrarily down‐regulated in BC tissue. In exosomes samples, only miR‐122‐5p was significantly up‐regulated as in plasma for BC patients. In conclusion, we identified a 5‐miRNA plasma panel (let‐7b‐5p, miR‐122‐5p, miR‐146b‐5p, miR‐210‐3p and miR‐215‐5p) that could serve as a promising biomarker for BC detection.
MIR155HG is a prognostic biomarker and associated with immune infiltration and immune checkpoint molecules expression in multiple cancers
Authors: Peng Lirong , Chen Zhanfei , Chen Yiyin , Wang Xiaoqian , Tang Nanhong 
Published: October 2019

AbstractIn recent years, immune checkpoint inhibitor has achieved remarkable success in multiple cancer treatment. However, how to pre‐judge which patients are suitable for immune checkpoint inhibitor is a difficult problem. We use the existing public bioinformatics database to comprehensively analyze the relationship between clinical data of various cancers with immune checkpoint blocking molecules and long non‐coding RNAs (lncRNAs), and try to find the potential predictive value of lncRNA for immunotherapy with checkpoint inhibitors. In this study, we found that: (a) high expression of lncRNA MIR155 host gene (MIR155HG) was closely related to better overall survival (OS) in cholangiocarcinoma (CHOL), lung adenocarcinoma (LUAD), and skin cutaneous melanoma (SKCM), and have better disease‐free survival (DFS) in CHOL. Meanwhile, the high level of MIR155HG was associated with poorer OS in glioblastoma multiforme (GBM), kidney renal clear cell carcinoma (KIRC), brain lower grade glioma (LGG), and uveal melanoma (UVM). (b) The expression of MIR155HG was significantly correlated with infiltrating levels of immune cells and immune molecules, especially with immune checkpoint molecules such as programmed cell death protein 1 (PD‐1), PD‐1 ligand 1 (PD‐L1), and cytotoxic T lymphocyte‐associated antigen 4 (CTLA4) in most kinds of cancers. (c) Detection of clinical CHOL and liver hepatocellular carcinoma tissues confirmed that there was a strong positive correlation between MIR155HG expression and the levels of CTLA4 and PD‐L1. MIR155 host gene can be used as a prognostic marker in multiple cancers, and of great value in predicting the curative effect of immune checkpoint inhibitor therapy owing to it is closely related with immune cells infiltration and immune checkpoint molecules expression.
A Method for High‐Throughput Measurements of Viscosity in Sub‐micrometer‐Sized Membrane Systems
Authors: Chwastek Grzegorz , Petrov Eugene P. , Sáenz James Peter 
Published: October 2019

AbstractTo unravel the underlying principles of membrane adaptation in small systems like bacterial cells, robust approaches to characterize membrane fluidity are needed. Currently available relevant methods require advanced instrumentation and are not suitable for high‐throughput settings needed to elucidate the biochemical pathways involved in adaptation. We developed a fast, robust, and financially accessible quantitative method to measure the microviscosity of lipid membranes in bulk suspension using a commercially available plate reader. Our approach, which is suitable for high‐throughput screening, is based on the simultaneous measurements of absorbance and fluorescence emission of a viscosity‐sensitive fluorescent dye, 9‐(2,2‐dicyanovinyl)julolidine (DCVJ), incorporated into a lipid membrane. We validated our method using artificial membranes with various lipid compositions over a range of temperatures and observed values that were in good agreement with previously published results. Using our approach, we were able to detect a lipid phase transition in the ruminant pathogen Mycoplasma mycoides.
Oligonucleotides Containing Phenoxazine Artificial Nucleobases: Triplex‐Forming Abilities and Fluorescence Properties
Authors: Fujii Akane , Nakagawa Osamu , Kishimoto Yuki , Nakatsuji Yusuke , Nozaki Natsumi , Obika Satoshi 
Published: October 2019

Abstract1,3‐Diaza‐2‐oxophenoxazine (“phenoxazine”), a tricyclic cytosine analogue, can strongly bind to guanine moieties and improve π–π stacking effects with adjacent bases in a duplex. Phenoxazine has been widely used for improving duplex‐forming abilities. In this study, we have investigated whether phenoxazine and its analogue, 1,3,9‐triaza‐2‐oxophenoxazine (9‐TAP), could improve triplex‐forming abilities. A triplex‐forming oligonucleotide (TFO) incorporating a phenoxazine component was found to show considerably decreased binding affinity with homopurine/homopyrimidine double‐stranded DNA, so the phenoxazine system was considered not to function as either a protonated cytosine or thymine analogue. Alternatively, a 9‐TAP‐containing artificial nucleobase developed by us earlier as a new phenoxazine analogue functioned as a thymine analogue with respect to AT base pairs in a parallel triplex DNA motif. The fluorescence of the 9‐TAP moiety was maintained even in triplex (9‐TAP:AT) formation, so 9‐TAP might be useful as an imaging tool for various oligonucleotide nanotechnologies requiring triplex formation.
Outcomes of hypertrophic obstructive cardiomyopathy patients undergoing alcohol septal ablation with a standard 3 mL dose of ethanol: Focus on long‐term safety
Authors: Kashtanov Maksim G. , Rzhannikova Anastasiya D. , Chernyshev Sergey D. , Kardapoltsev Lev V. , Idov Eduard M. , Berdnikov Sergey V. , Kochmasheva Valentina V. 
Published: October 2019

AbstractObjectivesThe objective of this research was to assess the long‐term results of alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy (HOCM), with all of them receiving a standard 3 mL ethanol dose.BackgroundGenerally, ethanol (0.5–3 mL) is infused depending on a septal artery width or interventricular septum (IVS) thickness during alcohol septal ablation. We injected 3 mL of ethanol irrespective of IVS thickness or perforator width in all cases.MethodsBetween 2000 and 2017, 150 HOCM patients (78 males, 72 females) underwent alcohol septal ablation procedures. In all cases we intentionally used the constant dose of ethanol (3 mL). The median of age was 52 (interquartile range: 41–60) years.ResultsThe median of follow‐up was 71 (interquartile range: 36–110) months. Hospital mortality was 0.67% (one patient died of sepsis). Perioperative high‐grade atrioventricular blocks required permanent pacemaker implantations—18 (12%). Long‐term survival rates were as follows: 95.1% (95% confidence interval [CI]: 92.7–97.5%), 85.8% (95% CI: 83.7–87.0%), and 81.7% (95% CI: 79.7–83.7%) at 5‐, 10‐, and 15‐year follow‐up, respectively. One‐sample log‐rank test revealed no significant differences in 15‐year survival rates between the alcohol septal ablation cohort and age‐ and sex‐matched Russian population.ConclusionsAlcohol septal ablation with the standard (3 mL) ethanol dose is safe and efficient. Survival rates after alcohol septal ablation are comparable with those in age‐ and sex‐matched general Russian population.
Chondroblastic osteosarcoma—A case report and review of literature
Authors: Mamachan Priya , Dang Vishal , Bharadwaj Neelkamal Sharda , DeSilva Natalia , Kant Priyanka 
Published: October 2019

Key Clinical MessageOsteosarcoma is the most common malignancy of mesenchymal cells mostly originating within long bones, but rarely in the jaws. This report illustrates a case of chondroblastic osteosarcoma in the region of anterior maxilla in a 58‐year‐old male patient previously treated for ossifying fibroma of the same site.
Alcoholic hepatitis masquerading as tumor infiltration: Reversibility after abstinence
Authors: Gluskin Adam B. , Dueker Jeffrey M. , El Hag Mohamed , Puthenpurayil Kurian J. , Bataller Ramon 
Published: October 2019

AbstractA subset of patients with alcoholic hepatitis present with atypical imaging resembling hepatic tumor infiltration. Our case involves a patient who was initially thought to have multiple large hepatic metastases, ultimately found to have alcoholic hepatitis. It is essential to ask about alcohol use when clinical suspicion is high.
Spark Plasma Sintering Treatment for Introduction of Oxygen Vacancy in Pt Dispersed SrTiO3 for Increasing Photocatalytic Water Splitting Activity
Authors: Kim Yoonyoung , Watanabe Motonori , Takagaki Atsushi , Matsuda Junko , Ishihara Tatsumi 
Published: October 2019

AbstractSpark plasma sintering (SPS) treatment was studied for Pt dispersed SrTiO3 as photocatalytic water splitting catalyst. The oxygen vacancy was introduced by SPS treatment and it was found that H2 formation rate was increased by SPS treatment since large amount of oxygen vacancy was introduced. H2 formation rate became the highest (6.15 mmol h−1 g−1) at 2.5 wt% Pt dispersed on SrTiO3 and this H2 formation rate was almost double of Pt loaded SrTiO3 and O2 formation rate was also much increased (5.66 mmol h−1 g−1). ESR measurement suggests that amount of Ti3+ was intense after SPS treatment with 2.5 wt% Pt. Therefore, it seems that the oxygen vacancy introduced by SPS treatment effectively worked for charge separation and photocatalytic activity of SrTiO3 to water splitting was increased.
Current Status of Self‐Supported Catalysts for Robust and Efficient Water Splitting for Commercial Electrolyzer
Authors: Kwon Jiseok , Han HyukSu , Choi Seungun , Park Keemin , Jo Seonghan , Paik Ungyu , Song Taeseup 
Published: October 2019

AbstractThe development of cost effective and high‐performance electrocatalyst is challenging but essential for realizing industrial hydrogen production by electolyzer. Electrocatalysts for water splitting must have active catalytic performance as well as high stability in strong alkaline or acidic media to be used in commercial elecrolyzer. Transition metal based electrocatalysts are considered as highly promising candidates due to their excellent oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) performance and stability with low materials cost. Recently, binder free self‐supported electrocatalysts based on transition metals have emerged as state‐of‐the‐art catalytic electrodes due to their high activity and robustness. These properties are attributed to lack of catalyst powder aggregation and a strong synergetic effect between the electrode surface and catalyst. In this mini review, recent development in self‐supported electrocatalysts for OER, HER and also bifunctional OER & HER are reviewed in terms of superior activity and robust stability. Material design strategies, structural and compositional properties, and catalytic performance of recently reported self‐supported electrocatalysts are summarized. Finally, overview of recent studies, challenges and prospects related to self‐supported electrocatalysts are discussed.
Fluorescence and Morphology of Self‐Assembled Nucleobases and Their Diphenylalanine Hybrid Aggregates
Authors: Avitabile Concetta , Diaferia Carlo , Roviello Valentina , Altamura Davide , Giannini Cinzia , Vitagliano Luigi , Accardo Antonella , Romanelli Alessandra 
Published: October 2019

AbstractStudies carried out in recent decades have revealed that the ability to self‐assemble is a widespread property among biomolecules. Small nucleic acid moieties or very short peptides are able to generate intricate assemblies endowed with remarkable structural and spectroscopic properties. Herein, the structural/spectroscopic characterization of aggregates formed by nucleobases and peptide nucleic acid (PNA)–peptide conjugates are reported. At high concentration, all studied nucleobases form aggregates characterized by previously unreported fluorescence properties. The conjugation of these bases, as PNA derivatives, to the dipeptide Phe–Phe leads to the formation of novel hybrid assemblies, which are characterized by an amyloid‐like association of the monomers. Although these compounds share the same basic cross‐β motif, the nature and number of PNA units have an important impact on both the level of structural order and the intrinsic fluorescence of the self‐assembled nanostructure.
Mesoporous Cu‐Ce‐Ox Solid Solutions from Spray Pyrolysis for Superior Low‐Temperature CO Oxidation
Authors: Li Rengui , Yang Yixuan , Sun Na , Kuai Long 
Published: October 2019

AbstractDevelopment of Pt group metal‐free catalysts for low‐temperature CO oxidation remains critical. In this work, active and stable mesoporous Cu‐Ce‐Ox solid solutions are prepared by using spray pyrolysis. The specific surface areas and pore volumes reach as high as 170 m2 g−1 and 0.24 cm3 g−1, respectively. The results of CO oxidation study suggest that (1) the catalyst obtained by spray pyrolysis possesses much higher activity than those made by co‐precipitation, sol‐gel, and hydrothermal methods; (2) the optimal Cu0.2‐Ce0.8‐Ox solid solution presents a reactivity over 28 times that of both single‐component CuO and CeO2 at 70 °C. Based on the study of pure‐phase Cu‐Ce‐Ox solid solutions by selective leaching of segregated CuOx species, the active center for CO oxidation is confirmed as the bimetallic Cu‐Ce‐O site, whereas the individual CuOx particles not only act as spectators but also block the active Cu‐Ce‐O sites. A low apparent activation energy of approximately 48 kJ mol−1 is detected for CO oxidation at the Cu‐Ce‐O site, making Cu‐Ce‐Ox solid solutions able to present high activity at low temperature. Furthermore, the Cu‐Ce‐Ox catalysts exhibit excellent stability and thermal tolerance toward CO oxidation.