bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Algorithm for Extra-Articular Reinforcement in ACL Injury Based on Rotational Instability
Authors: Jorge Pedro , Guglielmetti Luiz Gabriel , Helito Camilo , Canuto Sérgio , Pádua Vitor , Escudeiro Diego 
Published: November 2024

Background: The results of surgical reconstructions of the anterior cruciate ligament (ACL) are improving with the association of extra-articular reinforcements, such as anterolateral ligament reconstruction and Lemaire tenodesis. However, ACL injury can occur through various mechanisms, and when there are valgus and external rotation of the tibia, anteromedial rotational instability (AMRI) may develop. Articular reinforcement in the anteromedial quadrant, in the topography of the anterior oblique ligament (AOL), can be an important tool for patients with ACL injury and external rotation instability. Indications: The physical examination under anesthesia in patients undergoing ACL reconstruction who are candidates for extra-articular reinforcements provides important information about rotational instability. Patients with instability in external rotation may benefit from anteromedial reinforcement in the AOL’s topography. Technique Description: We propose an algorithm to be followed in patients with ACL injury and indication for extra-articular reinforcement. Patients with a positive pivot shift, indicating internal rotation instability of the knee, should undergo anterolateral reinforcements, as well as those patients with joint hyperlaxity. The algorithm suggests performing the anterior drawer in external rotation (ADER) test. When positive in isolation, anteromedial reinforcement is indicated. When the physical examination shows both positive ADER and pivot shift, both medial and lateral extra-articular reinforcement could be performed. Results: This new type of extra-articular reinforcement, in the AOL’s topography, appears to be an important tool for improving surgical outcomes in ACL reconstructions. AMRI is a risk factor for central pivot reconstruction failure and should be investigated and treated, as proposed by the algorithm. Conclusions: Clinical examination of the ACL-injured knee, preferably under anesthesia, should include internal rotational and external rotational examination (pivot-shift and ADER tests). AMRI, when detected, should be treated, and the AOL reconstruction seems to be a good alternative. We propose a new algorithm based on rotational instability to make our extra-articular reinforcement in ACL patients. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Different associations of atherogenic index of plasma, triglyceride glucose index, and hemoglobin A1C levels with the risk of coronary artery calcification progression according to established diabetes
Authors: Won Ki-Bum , Choi Su-Yeon , Chun Eun Ju , Park Sung Hak , Sung Jidong , Jung Hae Ok , Chang Hyuk-Jae 
Published: November 2024

Abstract
Background
Both insulin resistance and hyperglycemia are important risk factors for atherosclerosis. While the characteristics of atherosclerosis are obviously different according to established diabetes, little has been known regarding the risk of coronary artery calcification (CAC) progression related to the biomarkers of atherogenic index of plasma (AIP), triglyceride glucose (TyG) index, and hemoglobin A1C (HbA1C) in conditions with and without diabetes.

Methods
We analyzed 12,326 asymptomatic Korean adults (mean age 51.7 ± 8.5 years; 84.2% males; 15.8% with diabetes) over a median follow-up period of 3.0 years. AIP was defined as the base-10 logarithm of the ratio of triglyceride concentration (mmol/L) to high-density lipoprotein cholesterol (mmol/L). The TyG index was calculated as ln (fasting triglycerides [mg/dL] × fasting glucose [mg/ dL]/2). CAC progression was defined using the SQRT method, as a difference of ≥ 2.5 between the square roots (√) of baseline and follow-up coronary artery calcium scores (CACS) (Δ√transformed CACS). Logistic regression models adjusted for interscan periods were used to estimate the odds ratio (OR).

Results
The levels of AIP, TyG index, and HbA1C were significantly higher in diabetics than in non-diabetics. CAC progression was more frequently observed in diabetics (46.9%) than in non-diabetics (28.0%). After adjusting for age, sex, hypertension, hyperlipidemia, obesity, current smoking status, serum creatinine levels, baseline CACS, and interscan period, AIP (per-0.1 unit increase) was associated with CAC progression in only non-diabetics (OR: 1.04, 95% confidence interval [CI]: 1.02 − 1.06; P < 0.001). In contrast, HbA1C level (per-1% increase) was significantly associated with CAC progression in only diabetics (OR: 1.19, 95% CI: 1.08 − 1.32; P = 0.001). The TyG index (per-1 unit increase) was associated with CAC progression in both non-diabetics (OR: 1.32, 95% CI: 1.19 − 1.46; P < 0.001) and diabetics (OR: 1.33, 95% CI: 1.10 − 1.60; P = 0.003).

Conclusions
The associations between AIP, TyG index, and HbA1C levels with CAC progression vary according to established diabetes. Of these biomarkers, TyG index is independently associated with CAC progression irrespective of established diabetes.

Graphical abstract
Contextualising the job demands–resources model: a cross-sectional study of the psychosocial work environment across different healthcare professions
Authors: Gynning Britta Elsert , Karlsson Elin , Teoh Kevin , Gustavsson Per , Christiansen Filip , Brulin Emma 
Published: November 2024

Abstract
Background
The deteriorating psychosocial work environment among healthcare workers in Sweden, influenced by demanding working conditions and resource constraints, affects individual well-being and patient care quality. Healthcare workers, including physicians, registered nurses, and nursing assistants, often work interdependently and share workplaces, yet are three completely different professions. Nonetheless, comprehensive studies comparing their psychosocial work environments are scarce; often focusing on healthcare workers either separately or as a homogenous group, but rarely comparative.

Aim
Utilising the job demands–resources model, this study investigated variations in the psychosocial work environment among Swedish healthcare workers. We wanted to identify how the antecedents of individual well-being, in the form of demands and resources, differed between healthcare workers.

Method
Data from the 2022 Longitudinal Occupational Health Survey for Health Care in Sweden were analysed; the participants included 7589 physicians, registered nurses, and nursing assistants. The analysis involved descriptive statistics, including measures of means and analysis of covariance (ANCOVA), employing the Bonferroni correction for multiple post hoc comparisons. The ANCOVA was also stratified by working factors, including years of work experience and employment within the private/public sector.

Results
The study revealed significant variations in how healthcare workers perceive their psychosocial work environment. Physicians faced the highest level of Quantitative Demands (mean (x̄) 3.15; 95% CI 3.11–3.19), while registered nurses reported the most Emotional Demands (x̄ 3.37; 95% CI 3.32–3.41). Nursing assistants had the highest grand means for the imbalance between Efforts and Rewards (Effort Reward Imbalance) (x̄ 1.49; 95% CI 1.49–1.49) and an imbalance between Work and Private Life (Work–Life Interference) (x̄ 3.20, 95% CI 3.15–3.25), along with limited resources. The stratified analysis showed that years of experience and the sector affected healthcare workers' perceptions of their psychosocial working environment. For example, registered nurses working in the private sector reported better working conditions than registered nurses working in the public sector. The situation for nursing assistants was reversed.

Conclusion
Psychosocial work environments are experienced differently between and within healthcare professions in Sweden. This study provides crucial insights for improving workplace conditions and consequently enhancing healthcare professionals’ well-being and quality of patient care.
NEK7 induces lactylation in Alzheimer’s disease to promote pyroptosis in BV-2 cells
Authors: Cheng Jing , Zhao Hui 
Published: November 2024

AbstractAlzheimer’s disease (AD), an age-related neurodegenerative disorder, is characterized by irreversible brain tissue degeneration. The amyloid-β (Aβ) cascade hypothesis stands as the predominant paradigm explaining AD pathogenesis. This study aimed to elucidate the mechanisms underlying Aβ-induced pyroptosis in AD. AD models were established using amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice and Aβ-treated BV-2 cells (5 µM, 24 h). NEK7 expression was evaluated in vitro and in vivo. Cell pyroptosis was assessed before and after NEK7 expression was inhibited in BV-2 cells. Adeno-associated virus (AAV) vectors carrying short hairpin RNA (shRNA) against NEK7 (AAV-sh-NEK7) were administered to mice to knockdown NEK7 in vivo. Spatial learning and memory abilities were evaluated using the Morris water maze test. The interaction between NEK7 and histone H4 lysine 12 lactylation (H4K12la) were then investigated. The results suggested that NEK7 expression was markedly elevated in both in vitro and in vivo AD models. Treatment with Aβ significantly reduced cell viability and enhanced pyroptosis in BV-2 cells; these effects were reversed by inhibiting NEK7. Furthermore, AD mice with NEK7 knockdown exhibited shorter escape latencies and increased time spent in the target quadrant, suggesting that NEK7 inhibition improved cognitive function and memory retention. Mechanistically, Aβ treatment induced histone lactylation in BV-2 cells, and suppression of lactylation attenuated NEK7 transcriptional activity and mRNA levels. In summary, elevated NEK7 expression promoted histone lactylation in BV-2 cells, thereby facilitating pyroptosis. Inhibition of NEK7 conferred protection against Aβ-induced cellular damage and enhanced cognitive performance and memory retention in AD model mice. Collectively, targeting NEK7 represents a potential therapeutic strategy for alleviating AD symptoms.
Graphical abstract
Obstructive shock and cardiac arrest due to diaphragmatic hernia after esophageal surgery: a case report
Authors: Minami Kensuke , Nakatsuka Rie , Nagaoka Satoshi , Hirota Masaki , Matsumoto Takashi , Kusu Takashi , Shingai Tatsushi , Makari Yoichi , Oshima Satoshi 
Published: November 2024

Abstract
Background
We report the exceedingly rare case of diaphragmatic hernia after esophageal surgery resulting in obstructive shock and cardiac arrest.

Case presentation
An 82-year-old man, who had undergone a robotic-assisted thoracoscopic esophagectomy and gastric tube reconstruction via a subcutaneously route with three-field lymphadenectomy for esophagogastric junction cancer at another hospital 3 months prior, complaining of persistent epigastric pain and nausea. Computed tomography revealed that the proximal jejunum had herniated through the esophageal hiatus into the left thoracic cavity, with dilation of the subcutaneous gastric tube and duodenum. He was urgently admitted, and a nasogastric tube was inserted. His respiratory and circulatory parameters were normal upon admission, however, nine hours after admission, there was a rapid increase in oxygen demand, and he subsequently developed shock. His blood pressure was 106/65 mmHg, pulse rate of 150bpm, respiratory rate of 30/min with an O2 saturation of 97% on High-flow nasal cannula FiO2:0.4, cyanosis and peripheral coldness appeared. Chest X-ray showed a severe mediastinal shift to the right, suggesting obstructive shock due to intestinal hernia into the thoracic cavity. Emergency surgery was planned, but shortly after endotracheal intubation, the patient experienced cardiac arrest. It was found that approximately 220 cm of small intestine had herniated into the thoracic cavity through the esophageal hiatus, and it was being strangulated by the diaphragmatic crura. A portion of the diaphragmatic crura was incised to manually reduce the herniated small intestine back into the abdominal cavity. The strangulated intestine was congested, but improvement in coloration was observed and it had not become necrotic. The procedure finished with closure of the esophageal hiatus. Intensive care was continued, but he died on postoperative day 29 because of complications including perforation of the descending colon and aspiration pneumonia.

Conclusion
Rapid progression of small intestine hernia into the thoracic cavity, leading to obstructive shock, was suspected. While this case was rare, early recognition of the condition and prompt reduction could have potentially led to life-saving outcomes.
Effects of Different Loading Programs on Finger Strength in Rock Climbers
Authors: Gilmore Natalie K. , Klimek Peter , Abrahamsson Emil , Baar Keith 
Published: November 2024

Abstract
Background
Climbing places high loads through the hands and fingers, and climbers may benefit from specific finger strength training (hangboarding) protocols. The purpose of this study was to evaluate the effect of a 10-minute low intensity hangboard finger strengthening protocol (“Abrahangs”), compared with the generally accepted Max Hangs protocol for training maximal grip strength.

Methods
We retrospectively evaluated the change in grip strength and Strength: Weight following Max Hangs, Abrahangs, or the two protocols performed concurrently in rock climbers who used the Crimpd app to log their training. Users who had completed two finger strength tests within a 4–16-week period were included. Climbers were grouped by the number of training sessions into: “Climbing Only”, “Abrahangs Only”, “Max Hangs Only” and “Both” Max Hangs and Abrahangs.

Results
Frequent low intensity finger loading was as effective at improving grip strength in climbers as training with maximal loads. Additionally, combining low intensity and maximal load training resulted in additive strength gains.

Conclusions
These results suggest that low-intensity long duration holds provide a promising training paradigm for training finger strength that is gentle enough to incorporate into existing training programs.
Initial labor market conditions and subsequent fertility behavior
Authors: Ramos Vincent Jerald 
Published: November 2024

AbstractThe conditions upon which young adults enter the labor market have been demonstrated to affect various later-life employment and family formation outcomes. After the 2008–2009 Global Financial Crisis, a thick strand of the literature has shown that precarious initial employment leads to postponed childbearing and higher ultimate childlessness. However, it is not only individual conditions that matter. Broader macroeconomic conditions upon entry also matter. The “scarring” literature has illustrated the consequences of entering the labor market during a recession on later life outcomes. Speaking to both strands and using detailed employment and birth histories of labor market entrants in Germany, this paper examines the effects of initial conditions, operationalized using fixed-term employment and recession year entry, on subsequent fertility behavior. To partly address bias from endogenous selection into initial conditions, we employ a two-step estimation strategy combining a non-parametric optimal full matching step and a parametric event history modeling step using the matched data. Results suggest that entering the labor market with a fixed-term contract is persistently and negatively associated with first births up to a decade after entry, and this pattern is pronounced only among women, whereas entering during a recession has persistent negative associations only among men.
Unveiling the phloem: a battleground for plant pathogens
Authors: Haider Mohammad Waris , Sharma Arpana , Majumdar Anik , Fayaz Falak , Bromand Ferdaws , Rani Upasana , Singh Vaibhav Kumar , Saharan Mahender Singh , Tiwari Rahul Kumar , Lal Milan Kumar , Kumar Ravinder 
Published: November 2024

AbstractPhloem is the primary conduit for transporting photosynthates and signaling molecules in plants, facilitating communication between various plant organs. As an ancient vascular tissue, phloem transports sugars, proteins, and hormones from source tissues to sinks over long distances. However, this vital transport system also serves as a battlefield where plants and pathogens compete for survival. The phloem’s nutrient-rich environment offers pathogens a secure habitat, protecting them from external threats while providing ample metabolic resources. Phloem-feeding insects, bacteria, fungi, and viruses exploit this system to access nutrients, leading to widespread diseases and yield losses. These insects can also transmit pathogens, such as viruses, which can evade the plants’ defense systems, causing systemic damage throughout the transport network. This review describes the mechanisms by which pathogens invade and colonize the phloem, the plant’s defense strategies, and their dynamic interactions. Understanding the phloem’s structural intricacies, physiological functions, and defense mechanisms provides a foundation for comprehending phloem–pathogen interactions. Insights into these interactions at the molecular level are crucial for developing innovative and effective disease management strategies. Genomics, proteomics, and bioinformatics advances have elucidated the interactions between phloem defenses and pathogen offenses. Finally, this review discusses integrated disease management strategies to counteract these pathogens, paving the way for improving plant health and resilience.
Exploring SLC30A6 as a potential prognostic, immunomodulatory, and therapeutic biomarker in various cancers with a focus on pancreatic cancer: a pan-cancer analysis
Authors: Maghool Fatemeh , Kadkhodaei Elyaderani Parisa , Mohammadzadeh Samaneh , Hosseini Amir , Heidari Aida , Samadi Pouria 
Published: November 2024

Abstract
Background
Our study investigates the multifaceted role of the gene SLC30A6 across 33 distinct cancer types. Understanding the function and impact of SLC30A6 in cancer biology is crucial, as previous studies have hinted at its aberrant expression and potential involvement in tumor progression. This research aims to elucidate the expression patterns, methylation variations, mutational signatures, and survival implications of SLC30A6, along with its engagement with the immune system in various cancers and specially in pancreatic cancer.

Methods
We conducted a comprehensive analysis of SLC30A6 using data from 33 different cancer types, and all data were analyzed in silico. The study involved examining expression levels, performing correlation analyses with clinical outcomes, assessing methylation variations, and identifying mutational signatures. Functional enrichment analyses were carried out to understand the gene's involvement in biological pathways. Additionally, we evaluated the relationship between SLC30A6 expression and immune cell infiltration levels to uncover its role in the tumor microenvironment.

Results
SLC30A6 was found to be significantly up-regulated in the majority of the 33 cancer types analyzed. High expression levels of SLC30A6 were consistently correlated with poor survival outcomes, indicating its potential role in cancer prognosis. Functional enrichment analyses revealed that SLC30A6 is involved in key pathways related to tumor progression, including cell proliferation and apoptosis. Moreover, SLC30A6 showed significant associations with diverse immune pathways, suggesting its involvement in immune regulation. Notably, our analysis demonstrated a significant correlation between SLC30A6 expression and the infiltration levels of key immune cells, highlighting its dual immunosuppressive and immunostimulatory roles in a pan-cancer context. Moreover, SLC30A6 is significantly overexpression in pancreatic cancer and have shown different clinical associations as above.

Conclusion
Our study provides comprehensive insights into the complex interplay between SLC30A6 and cancer development. These findings position SLC30A6 as a promising prognostic biomarker and therapeutic target across diverse cancer types, highlighting its importance in future cancer research and treatment strategies.
Optimal data-driven strategy for in-house and outsourced technological innovations by open banking APIs
Authors: Dezem Vinicius , Sachan Swati , Macedo Marcelo , Andrade Longaray André 
Published: November 2024

AbstractOpen banking is a customer consent-driven data-sharing framework to maintain interoperability among financial and non-financial institutions through secure application programming interfaces. Traditional retail banks are losing their competitive edge against digital banks, FinTech, and BigTech firms due to a higher outflow of customer account data than inflow. These firms capitalize on open banking data to launch innovative products and introduce “ready-to-deploy” Banking-as-a-Service platforms for end-to-end banking operations without the need to build full-scale infrastructures. Therefore, banks must reshape data-driven strategies to stay competitive. This research proposes a decision-support tool to select optimal digital strategies using the Strategic Value Index (SVI), a metric derived from analyzing multiple strategic objectives of bank stakeholders. The SVI minimizes implementation time and costs while maximizing operational action importance to a balanced digital strategy that combines both in-house and outsourced technological developments. The importance of operational action is quantified using evidential reasoning with fuzzy logic to address the challenge of aggregating incomplete and ambiguous banking data and assessments from multiple stakeholders. The theoretical approach is validated through a real application in a Latin American bank, and its findings are globally transferable. Cost and time data were sourced from public repositories, as made available accessible through government-mandated disclosures. The sensitivity analysis revealed that hybrid in-house and outsourced development is more flexible in meeting tight timelines and budget constraints. The combined approach is more cost-effective, time-efficient, and aligned with the internal needs of banks compared to either entirely in-house or fully outsourced models.