bluuebunny/crossref_metadata_2025_split huggingface dataset:
Swiss extractivism: Switzerland's role in Zambia's copper sector
Authors: Dobler Gregor , Kesselring Rita 
Published: July 2019

AbstractSwitzerland is usually not looked upon as a substantial economic actor in Africa. Taking Zambian copper as a case study, we show how important Swiss companies have become in the global commodities trade and the services it depends on. While big Swiss trading firms such as Glencore and Trafigura have generated increasing scholarly and public interest, a multitude of Swiss companies is involved in logistics and transport of Zambian copper.Swiss extractivism, we argue, is a model case for trends in today's global capitalism. We highlight thatservicification, a crucial element of African mining regimes today, creates new and more flexible opportunities for international companies to capture value in global production networks. These opportunities partly rely on business-friendly regulation and tax regimes in Northern countries, a fact which makes companies potentially vulnerable to reputation risks and offers opportunities to civil society actors criticising their role. New and different Swiss–Zambian connections emerge from civil society networks organising around companies’ economic activities.
Health Technology Assessment of Public Health Interventions Published 2012 to 2016: An Analysis of Characteristics and Comparison of Methods
Authors: Polus Stephanie , Mathes Tim , Klingler Corinna , Messer Melanie , Gerhardus Ansgar , Stegbauer Constance , Willms Gerald , Ehrenreich Heidi , Marckmann Georg , Pieper Dawid 
Published: July 2019

AbstractObjectivesThe aim of this study was to provide an overview of the methodological characteristics and compare the assessment methods applied in health technology assessments (HTAs) of public health interventions (PHIs).MethodsWe defined a PHI as a population-based intervention on health promotion or for primary prevention of chronic or nonchronic diseases. HTAs on PHIs were identified by systematically searching the Web pages of members of international HTA networks. We included only full HTA reports published between 2012 and 2016. Two reviewers extracted data on the methods used to assess effectiveness/safety, as well as on economic, social, cultural, ethical, and legal aspects using a-priori standardized tables.ResultsWe included ten HTAs provided by four different organizations. Of these, all reports assessed the effectiveness of the interventions and conducted economic evaluations, seven investigated social/cultural aspects, and four each considered legal and ethical aspects, respectively. Some reports addressed applicability, context/setting, and intervention fidelity issues in different ways. We found that most HTAs adapted their methods to some extent, for example, by including nonrandomized studies, expanding the search strategy, involving stakeholders, or applying a framework to guide the HTA process.ConclusionsOur analysis provides a comprehensive overview of methods applied in HTAs on public health interventions. We found that a heterogeneous set of approaches is used to deal with the challenges of evaluating complex public health interventions.
Fires, Smoke Exposure, and Public Health: An Integrative Framework to Maximize Health Benefits From Peatland Restoration
Authors: Marlier Miriam E. , Liu Tianjia , Yu Karen , Buonocore Jonathan J. , Koplitz Shannon N. , DeFries Ruth S. , Mickley Loretta J. , Jacob Daniel J. , Schwartz Joel , Wardhana Budi S. , Myers Samuel S. 
Published: July 2019

AbstractEmissions of particulate matter from fires associated with land management practices in Indonesia contribute to regional air pollution and mortality. We assess the public health benefits in Indonesia, Malaysia, and Singapore from policies to reduce fires by integrating information on fire emissions, atmospheric transport patterns, and population exposure to fine particulate matter (PM2.5). We use adjoint sensitivities to relate fire emissions to PM2.5 for a range of meteorological conditions and find that a Business‐As‐Usual scenario of land use change leads, on average, to 36,000 excess deaths per year into the foreseeable future (the next several decades) across the region. These deaths are largely preventable with fire reduction strategies, such as blocking fires in peatlands, industrial concessions, or protected areas, which reduce the health burden by 66, 45, and 14%, respectively. The effectiveness of these different strategies in mitigating human health impacts depends on the location of fires relative to the population distribution. For example, protecting peatlands through eliminating all fires on such lands would prevent on average 24,000 excess deaths per year into the foreseeable future across the region because, in addition to storing large amounts of fuel, many peatlands are located directly upwind of densely populated areas. We also demonstrate how this framework can be used to prioritize restoration locations for the Indonesian Peatland Restoration Agency based on their ability to reduce pollution exposure and health burden. This scientific framework is publicly available through an online decision support tool that allows stakeholders to readily determine the public health benefits of different land management strategies.
Dispersive Alfvén Wave Control of O+ Ion Outflow and Energy Densities in the Inner Magnetosphere
Authors: Hull A. J. , Chaston C. C. , Bonnell J. W. , Wygant J. R. , Kletzing C. A. , Reeves G. D. , Gerrard A. 
Published: July 2019

AbstractThe relationship between dispersive Alfvén waves (DAWs), magnetospheric activity, and O+ ion outflow/energy density is examined using measurements from the Van Allen Probes. We show that correlated DAW activity and O+ outflow/energization is a characteristic feature of the inner magnetosphere during active conditions and during storms persists for several hours over large L‐shell and azimuthal ranges of the plasma sheet. Though enhanced during substorm and storm active periods, these correlated features are most intense during geomagnetic storms. Comparisons show a linear relationship between DAW electric (and magnetic) field energy density and outflowing O+ energy. Statistical measurements from a large number of storms also reveal a linear relationship between DAW energy density and gross enhancements in energetic O+ energy densities. These observations support the notion that DAWs play an important role in the energization of O+ ions into and within the inner magnetosphere.
Profound and reproducible patterns of reduced regional gray matter characterize major depressive disorder
Authors: Hellewell Sarah C. , Welton Thomas , Maller Jerome J. , Lyon Matthew , Korgaonkar Mayuresh S. , Koslow Stephen H. , Williams Leanne M. , Rush A. John , Gordon Evian , Grieve Stuart M. 
Published: July 2019

AbstractReduced gray matter (GM) volume may represent a hallmark of major depressive disorder (MDD) neuropathology, typified by wide-ranging distribution of structural alteration. In the study, we aimed to replicate and extend our previous finding of profound and widespread GM loss in MDD, and evaluate the diagnostic accuracy of a structural biomarker derived from GM volume in an interconnected pattern across the brain. In a sub-study of the International Study to Predict Optimized Treatment in Depression (iSPOT-D), two cohorts of clinically defined MDD participants “Test” (n = 98) and “Replication” (n = 131) were assessed alongside healthy controls (n = 66). Using 3T MRI T1-weighted volumes, GM volume differences were evaluated using voxel-based morphometry. Sensitivity, specificity, and area under the receiver operating characteristic curve were used to evaluate an MDD diagnostic biomarker based on a precise spatial pattern of GM loss constructed using principal component analysis. We demonstrated a highly conserved symmetric widespread pattern of reduced GM volume in MDD, replicating our previous findings. Three bilateral dominant clusters were observed: Cluster 1: midline/cingulate (GM reduction: Test: 6.4%, Replication: 5.3%), Cluster 2: medial temporal lobe (GM reduction: Test: 8.2%, Replication: 11.9%), Cluster 3: prefrontal cortex (GM reduction: Test: 12.1%, Replication: 23.2%). We developed a biomarker reflecting the global pattern of GM reduction, achieving good diagnostic classification performance (AUC: Test = 0.75, Replication = 0.84). This study establishes that a highly specific pattern of reduced GM volume is a feature of MDD, suggestive of a structural basis for this disease. We introduce and validate a novel diagnostic biomarker based on this pattern.
Leaf economics and slow-fast adaptation across the geographic range of Arabidopsis thaliana
Authors: Sartori Kevin , Vasseur François , Violle Cyrille , Baron Etienne , Gerard Marianne , Rowe Nick , Ayala-Garay Oscar , Christophe Ananda , Jalón Laura Garcia de , Masclef Diane , Harscouet Erwan , Granado Maria del Rey , Chassagneux Agathe , Kazakou Elena , Vile Denis 
Published: July 2019

AbstractLife history strategies of most organisms are constrained by resource allocation patterns that follow a ‘slow-fast continuum’. It opposes slow growing and long-lived organisms with late investment in reproduction to those that grow faster, have earlier and larger reproductive effort and a short longevity. In plants, the Leaf Economics Spectrum (LES) depicts a leaf-level trade-off between the rate of carbon assimilation and leaf lifespan, as stressed in functional ecology from interspecific comparative studies. However, it is still unclear how the LES is connected to the slow-fast syndrome. Interspecific comparisons also impede a deep exploration of the linkage between LES variation and adaptation to climate. Here, we measured growth, morpho-physiological and life-history traits, at both the leaf and whole-plant levels, in 378 natural accessions of Arabidopsis thaliana. We found that the LES is tightly linked to variation in whole-plant functioning, and aligns with the slow-fast continuum. A genetic analysis further suggested that phenotypic differentiation results from the selection of different slow-fast strategies in contrasted climates. Slow growing and long-lived plants were preferentially found in cold and arid habitats while fast growing and short-lived ones in more favorable habitats. Our findings shed light on the role of the slow-fast continuum for plant adaptation to climate. More broadly, they encourage future studies to bridge functional ecology, genetics and evolutionary biology to improve our understanding of plant adaptation to environmental changes.
Simplified platform for mosaic in vivo analysis of cellular maturation in the developing heart
Authors: Goudy Julie , Henley Trevor , Méndez Hernán G. , Bressan Michael 
Published: July 2019

AbstractCardiac cells develop within an elaborate electro-mechanical syncytium that continuously generates and reacts to biophysical force. The complexity of the cellular interactions, hemodynamic stresses, and electrical circuitry within the forming heart present significant challenges for mechanistic research into the cellular dynamics of cardiomyocyte maturation. Simply stated, it is prohibitively difficult to replicate the native electro-mechanical cardiac microenvironment in tissue culture systems favorable to high-resolution cellular/subcellular analysis, and current transgenic models of higher vertebrate heart development are limited in their ability to manipulate and assay the behavior of individual cells. As such, cardiac research currently lacks a simple experimental platform for real-time evaluation of cellular function under conditions that replicate native development. Here we report the design and validation of a rapid, low-cost system for stable in vivo somatic transgenesis that allows for individual cells to be genetically manipulated, tracked, and examined at subcellular resolution within the forming four-chambered heart. This experimental platform has several advantages over current technologies, chief among these being that mosaic cellular perturbations can be conducted without globally altering cardiac function. Consequently, direct analysis of cellular behavior can be interrogated in the absence of the organ level adaptions that often confound data interpretation in germline transgenic model organisms.
Neuroprotective effects of oleic acid in rodent models of cerebral ischaemia
Authors: Song Jungbin , Kim Young-Sik , Lee Dong Hwan , Lee Sung Hyun , Park Hyo Jin , Lee Donghun , Kim Hocheol 
Published: July 2019

AbstractOleic acid (OA) is released from brain phospholipids after cerebral ischaemia; however, its role in ischaemic injury remains unknown. We hypothesised that OA has neuroprotective effects after cerebral ischaemia, which may be exerted through peroxisome proliferator-activated receptor gamma (PPAR-γ) activation, since OA is an endogenous ligand of PPAR-γ. The effects of OA administration were evaluated in rodent models of middle cerebral artery occlusion (MCAO), photothrombosis, and four-vessel occlusion (4-VO). We determined the time window of therapeutic opportunity and examined the ability of the PPAR-γ antagonist GW9662 to reverse OA’s protective effects after MCAO. We found that OA administration decreased the MCAO-induced infarct volume and functional deficits, photothrombosis-induced infarct volume, and 4-VO-induced hippocampal neuronal death. Additionally, OA was highly efficacious when administered up to 3 h after MCAO. Pre-treatment with GW9662 abolished the inhibitory effects of OA on the infarct volume and immunoreactivity of key inflammatory mediators in the ischaemic cortex. Our results indicate that OA has neuroprotective effects against transient and permanent focal cerebral ischaemia, as well as global cerebral ischaemia. It may have therapeutic value for the ischaemic stroke treatment with a clinically feasible therapeutic window. The OA-mediated neuroprotection might be attributable to its anti-inflammatory actions through PPAR-γ activation.
Relationships of Non-coding RNA with diabetes and depression
Authors: An Tian , Zhang Jing , Ma Yue , Lian Juan , Wu Yan-Xiang , Lv Bo-Han , Ma Meng-Hua , Meng Jun-Hua , Zhou Yun-Tao , Zhang Zhi-Yong , Liu Qing , Gao Si-Hua , Jiang Guang-Jian 
Published: July 2019

AbstractIn order to study the molecular differences between type 2 diabetes mellitus (T2DM) and T2DM with depression (DD), we aimed to screen the differential expression of lncRNA, mRNA, and circRNA in the blood of patients with T2DM and DD. Based on the self-rating depression scale (SDS), patient health questionnaire 9 (PHQ9), blood glucose and HbA1c, we divided the patients into T2DM and DD group. Peripheral blood was collected from the two groups of patients to perform lncRNA, mRNA, and circRNA expression profiling and screening DD-related specific molecules. Subsequently, bioinformatics analysis was performed to investigate the functions of differentially expressed genes (DEgenes). Finally, RT-PCR and lncRNA-mRNA regulatory network was performed to verify the expressions of lncRNAs and mRNAs related to the occurrence and development of DD. 28 lncRNAs, 107 circRNAs, and 89 mRNAs were identified in DD differential expression profiles. GO and pathway analysis found that 20 biological process (BP) related entities and 20 pathways associated with DD. The analysis shows that the genes that are differentially expressed in the DD group involved in the development of the neuropsychiatric system, immunity, and inflammation. Then, we screening for the important DElncRNA and mRNA associated with DD were verified by RT-PCR experiments and the results of RT-PCR were consistent with the sequencing results. LncRNA, circRNA, and mRNA differential expression profiles exist in DD patients compared with T2DM. The lncRNA-mRNA regulatory network analysis confirmed the crosslinking and complex regulation patterns of lncRNA and mRNA expression and verified the authenticity of the regulatory network.
Internal tsunami waves transport sediment released by underwater landslides
Authors: Brizuela Noel , Filonov Anatoliy , Alford Matthew H. 
Published: July 2019

AbstractAccelerated by gravity, submarine landslides transfer energy to the marine environment, most notably leading to catastrophic tsunamis. While tsunamis are thought to use less than 15% of the total energy released by landslides, little is known about subsurface processes comprising the rest of their energy budgets. Here, we analyze the first set of observations depicting a lake’s interior response to underwater landslides and find that sediment transport is modulated by baroclinic waves that propagate along vertical gradients in temperature and sediment concentration. When traveling along a shallow thermocline, these waves can reach past topographic features that bound turbidity currents and thus expand the influence area of underwater landslides. With order of magnitude calculations, we estimate that observed thermocline internal waves received roughly 0.7% of available landslide energy and infer their contribution to homogenize the lake’s thermodynamical properties by means of turbulent mixing. Lastly, we show that landslides in our data set modified the lake’s intrinsic dynamical modes and thus had a permanent impact on its circulation. This suggests that measurements of subsurface wave propagation are sufficient to diagnose bathymetric transformations. Our experiment constitutes the first direct observation of both internal tsunami waves and turbidity current reflection. Moreover, it demonstrates that background density stratification has a significant effect on the transport of sediment after submarine landslides and provides a valuable reference for numerical models that simulate submarine mass failures.
Solvodynamic Printing As A High Resolution Printing Method
Authors: Liu W. C. , Watt A. A. R. 
Published: July 2019

AbstractPrinting techniques are becoming increasingly prevalent in modern manufacturing. However, its biggest drawback is the limit in printing resolution. In this paper, we present solvodynamic printing as a novel printing system which aims to improve print resolution by incorporating an additional immiscible carrier solvent into the ink delivery system. The resolution is improved due to the solvent-solvent interactions between the ink and the carrier solvent which alter the contact angle of the ink on the substrate and limit the printed feature size. We demonstrate the proof of concept of solvodynamic printing by printing silver nanoparticle inks on a polyethylene naphthalate substrate. Silver nanoparticle tracks with widths of 35.2 ± 7.0 μm were achieved using a 300 μm nozzle. This is equivalent to 11.7 ± 2.3% of the nozzle diameter. The result shows great potential in solvodynamic printing as not many modern printing techniques can achieve such nozzle to feature size ratios.
Evidence and patterns of tuna spawning inside a large no-take Marine Protected Area
Authors: Hernández Christina M. , Witting Jan , Willis Ciara , Thorrold Simon R. , Llopiz Joel K. , Rotjan Randi D. 
Published: July 2019

AbstractThe Phoenix Islands Protected Area (PIPA), one of the world’s largest marine protected areas, represents 11% of the exclusive economic zone of the Republic of Kiribati, which earns much of its GDP by selling tuna fishing licenses to foreign nations. We have determined that PIPA is a spawning area for skipjack (Katsuwonus pelamis), bigeye (Thunnus obesus), and yellowfin (Thunnus albacares) tunas. Our approach included sampling larvae on cruises in 2015–2017 and using a biological-physical model to estimate spawning locations for collected larvae. Temperature and chlorophyll conditions varied markedly due to observed ENSO states: El Niño (2015) and neutral (2016–2017). However, larval tuna distributions were similar amongst years. Generally, skipjack larvae were patchy and more abundant near PIPA’s northeast corner, while Thunnus larvae exhibited lower and more even abundances. Genetic barcoding confirmed the presence of bigeye (Thunnus obesus) and yellowfin (Thunnus albacares) tuna larvae. Model simulations indicated that most of the larvae collected inside PIPA in 2015 were spawned inside, while stronger currents in 2016 moved more larvae across PIPA’s boundaries. Larval distributions and relative spawning output simulations indicated that both focal taxa spawned inside PIPA in all 3 study years, demonstrating that PIPA is protecting viable tuna spawning habitat.
Diffusion kurtosis MRI as a predictive biomarker of response to neoadjuvant chemotherapy in high grade serous ovarian cancer
Authors: Deen Surrin S. , Priest Andrew N. , McLean Mary A. , Gill Andrew B. , Brodie Cara , Crawford Robin , Latimer John , Baldwin Peter , Earl Helena M. , Parkinson Christine , Smith Sarah , Hodgkin Charlotte , Patterson Ilse , Addley Helen , Freeman Susan , Moyle Penny , Jimenez-Linan Mercedes , Graves Martin J. , Sala Evis , Brenton James D. , Gallagher Ferdia A. 
Published: July 2019

AbstractThis study assessed the feasibility of using diffusion kurtosis imaging (DKI) as a measure of tissue heterogeneity and proliferation to predict the response of high grade serous ovarian cancer (HGSOC) to neoadjuvant chemotherapy (NACT). Seventeen patients with HGSOC were imaged at 3 T and had biopsy samples taken prior to any treatment. The patients were divided into two groups: responders and non-responders based on Response Evaluation Criteria In Solid Tumours (RECIST) criteria. The following imaging metrics were calculated: apparent diffusion coefficient (ADC), apparent diffusion (Dapp) and apparent kurtosis (Kapp). Tumour cellularity and proliferation were quantified using histology and Ki-67 immunohistochemistry. Mean Kapp before therapy was higher in responders compared to non-responders: 0.69 ± 0.13 versus 0.51 ± 0.11 respectively, P = 0.02. Tumour cellularity correlated positively with Kapp (rho = 0.50, P = 0.04) and negatively with both ADC (rho = −0.72, P = 0.001) and Dapp (rho = −0.80, P < 0.001). Ki-67 expression correlated with Kapp (rho = 0.53, P = 0.03) but not with ADC or Dapp. In conclusion, Kapp was found to be a potential predictive biomarker of NACT response in HGSOC, which suggests that DKI is a promising clinical tool for use oncology and radiology that should be evaluated further in future larger studies.
A Pro-Inflammatory Biomarker-Profile Predicts Amputation-Free Survival in Patients with Severe Limb Ischemia
Authors: Gremmels Hendrik , Teraa Martin , de Jager Saskia C. A. , Pasterkamp Gerard , de Borst Gert J. , Verhaar Marianne C. 
Published: July 2019

AbstractPatients with Severe Limb Ischemia (SLI) have a high risk of amputation and mortality. Here, we investigated a panel of serum biomarkers with the aim of identifying biomarkers for major events and mechanisms that contribute to disease progression in established SLI. A panel of biomarkers including GROα, HGF, SCF, SCGFβ, SDF1α, TRAIL, IL-6, IL-8, FGFβ, GCSF, GMCSF, IP10, MCP1, PDGFbb, RANTES, TNFα, VEGF, sICAM, sVCAM, TM, and E-selectin was measured in serum samples from a subset (n = 108) of the JUVENTAS cohort. The primary outcome was major events, defined as major amputation or death. The inflammatory biomarkers IL-6, IL-8, GROα and IP-10 were significantly elevated in patients who reached a major endpoint. Results were validated in a secondary cohort (n = 146). Cox regression showed that adjusted hazard ratios were 1.40 (95% CI: 1.15–1.70, p = 0.0007) and 1.48 (95% CI 1.16–1.87, p = 0.001) for IL-6 and IP-10 in a fully adjusted model containing both biomarkers. A prediction model using IL-6 and IP-10 showed predictive accuracy with an AUC of ~ 78% in both discovery and validation cohorts, which is higher than previously published models. We conclude that inflammatory biomarkers predict major events in patients with SLI and allow the creation of biomarker-based risk-prediction models.