bluuebunny/crossref_metadata_2025_split huggingface dataset:
The deSUMOylase SENP2 coordinates homologous recombination and non-homologous end joining by independent mechanisms
Authors: Garvin Alexander J. , Walker Alexandra K. , Densham Ruth M. , Chauhan Anoop Singh , Stone Helen R. , Mackay Hannah L. , Jamshad Mohammed , Starowicz Katarzyna , Daza-Martin Manuel , Morris Joanna R. 
Published: November 2018

AbstractSUMOylation in the DNA double-strand break (DSB) response regulates recruitment, activity and clearance of repair factors. However, our understanding of a role for deSUMOylation in this process is limited. Here we identify different mechanistic roles for deSUMOylation in homologous recombination (HR) and non-homologous enjoining (NHEJ) through the investigation of the deSUMOylase SENP2. We find regulated deSUMOylation of MDC1 prevents excessive SUMOylation and its RNF4-VCP mediated clearance from DSBs, thereby promoting NHEJ. In contrast we show HR is differentially sensitive to SUMO availability and SENP2 activity is needed to provide SUMO. SENP2 is amplified as part of the chromosome 3q amplification in many cancers. Increased SENP2 expression prolongs MDC1 foci retention and increases NHEJ and radioresistance. Collectively our data reveal that deSUMOylation differentially primes cells for responding to DSBs and demonstrates the ability of SENP2 to tune DSB repair responses.
A Teensy microcontroller-based interface for optical imaging camera control during behavioral experiments
Authors: Romano Michael , Bucklin Mark , Mehrotra Dev , Kessel Robb , Gritton Howard , Han Xue 
Published: November 2018

AbstractBackgroundSystems neuroscience experiments often require the integration of precisely timed data acquisition and behavioral monitoring. While specialized commercial systems have been designed to meet various needs of data acquisition and device control, they often fail to offer flexibility to interface with new instruments and variable behavioral experimental designs.New methodWe developed a Teensy 3.2 microcontroller-based interface that offers high-speed, precisely timed behavioral data acquisition and digital and analog outputs for controlling sCMOS cameras and other devices.ResultsWe demonstrate the flexibility and the temporal precision of the Teensy interface in two experimental settings. We first used the Teensy interface for reliable recordings of an animal’s directional movement on a spherical treadmill, while delivering repeated digital pulses that can be used to control image acquisition from a sCMOS camera. In another example, we used the Teensy interface to control temporally precise delivery of an auditory stimulus and a gentle eye puff in a trace conditioning eye blink behavioral paradigm, while delivering repeated digital pulses to initiate camera image acquisition.Comparison with existing methodsThis interface allows high-speed and temporally precise digital data acquisition and device control during diverse behavioral experiments.ConclusionThe Teensy interface, consisting of a Teensy 3.2 and custom software functions, provides a temporally precise, low-cost, and flexible platform to integrate sCMOS camera control into behavioral experiments.
Charting the diversity of Uncultured Viruses of Archaea and Bacteria
Authors: Coutinho Fh , Rodríguez-Valera F 
Published: November 2018

AbstractViruses of Archaea and Bacteria are among the most abundant and diverse biological entities on Earth. Unraveling their biodiversity has been challenging due to methodological limitations. Recent advances in culture-independent techniques, such as metagenomics, shed light on viral dark matter, revealing thousands of new viral genomes at an unprecedented scale. However, these novel genomes have not been properly classified and the evolutionary associations between them were not resolved. Here, we performed phylogenomic analysis of nearly 200,000 viral genomic sequences to establish GL-UVAB: Genomic Lineages of Uncultured Viruses of Archaea and Bacteria. GL-UVAB yielded a 44-fold increase in the amount of classified genomes. The pan-genome content of the identified lineages revealed their infection strategies, potential to modulate host physiology and mechanisms to escape resistance systems. Furthermore, using GL-UVAB for annotating metagenomes from multiple ecosystems revealed elusive habitat distribution patterns of viral communities. These findings expand the understanding of the diversity, evolution and ecology of viruses of prokaryotes.
Integrated ligand and structure-based investigation of structural requirements for silent information regulator [SIRT1] activation
Authors: Gupta Amit K. , Choi Sun 
Published: November 2018

AbstractA series of imidazothiazole and oxazolopyridine derivatives as human silent information regulator (SIRT1) activators were subjected to the integrated 2D and 3D QSAR approaches. The derived 3D QSAR models yielded high cross validated q2 values of 0.682 and 0.628 for CoMFA and CoMSIA respectively. The non-cross validated correlation values of r2training = 0.89; predictive r2test = 0.69 for CoMFA and r2=0.87; predictive r2test =0.67 for CoMSIA reflected the statistical significance of the developed model. The steric, electrostatic, hydrophobic and hydrogen bond acceptor interactions have been found important in describing the variation in human SIRT1 activation. Further, 2D QSAR model for the same dataset yielded high statistical significance and derived 2D model’s parameters corroborated with 3D model in terms of features. The developed model was also validated through the available active conformation structure of SIRT1. Developed models may be useful for the identification of potential novel human SIRT1 activators as therapeutic agent.
NanoARG: A web service for identification of antimicrobial resistance elements from nanopore-derived environmental metagenomes
Authors: Arango-Argoty G. A. , Dai D. , Pruden A. , Vikesland P. , Heath L. S. , Zhang L. 
Published: November 2018

ABSTRACTDirect selection pressures imposed by antibiotics, indirect pressures by co-selective agents, and horizontal gene transfer are fundamental drivers of the evolution and spread of antibiotic resistance. Therefore, effective environmental monitoring tools should ideally capture not only antibiotic resistance genes (ARGs), but also mobile genetic elements (MGEs) and indicators of co-selective forces, such as metal resistance genes (MRGs). Further, a major challenge towards characterizing potential human risk is the ability to identify bacterial host organisms, especially human pathogens. Historically, short reads yielded by next-generation sequencing technology has hampered confidence in assemblies for achieving these purposes. Here we introduce NanoARG, an online computational resource that takes advantage of long reads produced by MinION nanopore sequencing. Specifically, long nanopore reads enable identification of ARGs in the context of relevant neighboring genes, providing relevant insight into mobility, co-selection, and pathogenicity. NanoARG allows users to upload sequence data online and provides various means to analyze and visualize the data, including quantitative and simultaneous profiling of ARG, MRG, MGE, and pathogens. NanoARG is publicly available and freely accessible at http://bench.cs.vt.edu/nanoARG.
Transformation of accounting through digital standardisation
Authors: Troshani Indrit , Locke Joanne , Rowbottom Nick 
Published: November 2018

PurposeCorporate reporting infrastructure and communication are being transformed by the emergence of digital technologies. A key element of the digital accounting infrastructure underpinning international corporate reporting is the IFRS Taxonomy, a digital representation of international accounting standards that is required by firms to produce digital corporate reports. The purpose of this paper is to trace the development, governance and adoption of the IFRS Taxonomy to highlight the implications for accounting practice and standard-setting.Design/methodology/approachThe authors mobilise Actor Network Theory and a model of transnational standardisation to analyse the process surrounding the formation and diffusion of the IFRS Taxonomy as a legitimate “reference” of the IFRS Standards. The authors trace the process using interview, observation and documentary evidence.FindingsThe analysis shows that while the taxonomy enables IFRS-based reporting in the digital age, tensions and detours result in the need for a realignment of the perspectives of both accounting standard-setters and taxonomy developers that have transformative implications for accounting practice and standard-setting.Originality/valueThe study explains how and why existing accounting standards are transformed by technology inscriptions with reflexive effects on the formation and diffusion of accounting standards. In doing so, the paper highlights the implications that arise as accounting practice adapts to the digitalisation of corporate reporting.
Determinants and academic achievement effect of Facebook use in educational communication among university students
Authors: Goh Chin Fei , Rasli Amran , Tan Owee Kowang , Choi Sang Long 
Published: November 2018

Purpose
The purpose of this paper is to examine the factors that drive students to use Facebook for educational communication and explore the impact of Facebook use for educational communication on perceived academic achievement.

Design/methodology/approach
A survey was conducted through a self-administered questionnaire to collect data from student Facebook users at a large technology and engineering university in Malaysia. Partial least squares path modeling was used to test the hypotheses in the research model.

Findings
This empirical study showed that Facebook use in educational communication is determined by subjective norms and purposive value. Facebook use in educational communication positively affected perceived academic achievement.

Practical implications
The findings provide useful insight for higher institutions and educators regarding the potential academic effects of integrating Facebook into higher education learning. Moreover, this study provides insight into the factors that drive Facebook use in educational communication.

Originality/value
Prior studies have largely investigated the determinants and the effects of Facebook use among university students. However, little research has focused on educational communication phenomena. This study investigated determinants and academic achievement effect of Facebook use in educational communication among university students.
Understanding refugee entrepreneurship incubation – an embeddedness perspective
Authors: Meister Alexander Dominik , Mauer René 
Published: November 2018

Purpose
Recent years have seen a wave of immigration in western countries. Entrepreneurship can foster refugees’ integration in the labour market. Hence, the authors observe an emergence of incubators with social purpose, addressing the key challenges of refugee entrepreneurs. The purpose of this paper is to look at the particularities and the impact of business incubation on entrepreneurial development and embeddedness of refugee entrepreneurs in the host country by applying the theoretical lens of mixed embeddedness theory.

Design/methodology/approach
This paper is based on a qualitative case study approach exploring one business incubation model for refugee entrepreneurs in Germany. For a multi-stakeholder perspective, the data were collected through a participatory focus group workshop and semi-structured interviews of refugee entrepreneurs and incubator stakeholders (e.g. incubator management, mentors and partners) contributing to the incubation. The data collection extends over the duration of five months of the incubation programme.

Findings
The empirical results emphasise the impact of the business incubator on refugee entrepreneur’s development and embeddedness. In this analysis, the authors identify key themes of a particular incubation process addressing the lack of embeddedness and barriers to refugee entrepreneurs in the host country. From the results, the authors elaborate a particular business incubation process framework of refugee entrepreneurs.

Originality/value
The findings enhance the understanding how business incubation contributes to the embeddedness of refugee entrepreneurs in their new hosting environment. Thus, this research contributes to the existing literature by extending incubation model frameworks towards refugee entrepreneurship and embeddedness perspectives. Furthermore, the study emphasises the role of the incubator in the context of the dimensions of the mixed embeddedness of the refugee entrepreneurs.
Sport and peacebuilding in post-conflict societies: the role of Open Fun Football Schools in Kosovo
Authors: Krasniqi Sanije , Krasniqi Besnik 
Published: November 2018

Purpose
The purpose of this paper is to fill the gap in the research literature on how sport can be used more productively as a peacebuilding device in post-conflict countries.

Design/methodology/approach
This paper uses interviewing method that includes both semi-structured and unstructured interviews with trainers, instructors and children involved in implementing Open Fun Football Schools (OFFSs) in Kosovo.

Findings
Findings show that OFFSs have played a vital role in peacebuilding in Kosovo by bringing together people from different ethnic backgrounds in Kosovo, which contributed to social inclusion of Albanians and Serbs, and other communities by changing their initial attitudes toward one another.

Research limitations/implications
The main research limitation is the usage of semi-structured and unstructured questionnaires instead of structured questionnaires, which would provide more generalized conclusions about the OFFSs. More research is needed on this topic to investigate the effect of similar programs in other country contexts.

Practical implications
The most important practical implication of the research is that conflict mitigation through football sports programs and activities can be used in other similar contexts by donors and the international community. OFFSs offer a hope for peacebuilding, and if adequately implemented can contribute to peacebuilding in post-conflict societies similar to Kosovo’s context. The positive attitude changes as a result of participation in the OFFS programs shows that these joint programs can promote better ethnic relations. There is a need for the expansion of such programs to reach more people.

Originality/value
The study provides an original contribution as there has been almost no prior research which actually measured the effects of OFFSs on change of youth attitudes through the integrated sport programs with different ethnicity in Kosovo.
“Ethnographic” thematic phenomenography
Authors: Forster Marc 
Published: November 2018

Purpose
The workplace is a context of increasing interest in information literacy research, if not necessarily the most visible (Cheuk, 2017). Several studies have described contextual, relationship-based experiences of this subjective, knowledge-development focussed phenomenon (Forster, 2017b). What research contexts and methods are likely to be most effective, especially in workplaces which contain professions of widely differing ontologies and epistemological realities? The paper aims to discuss these issues.

Design/methodology/approach
An analysis and description of the value and validity of a “qualitative mixed methods” approach in which the thematic form of phenomenography is contextualised ethnographically.

Findings
This paper describes a new research design for investigation into information literacy in the workplace, and discusses key issues around sampling, data collection and analysis, suggesting solutions to predictable problems. Such an approach would be centred on thematic phenomenographic data from semi-structured interviews, contextualised by additional ethnographic methods of data collection. The latter’s findings are analysed in light of the interview data to contextualise that data and facilitate a workplace-wide analysis of information literacy and the information culture it creates.

Originality/value
Insights from recent research studies into information literacy in the workplace have suggested the possibility of an epistemologically justifiable, qualitative mixed methods design involving an ethnographic contextualisation of a thematic phenomenographic analysis of the information culture of an ontologically varied and complex workplace – with the potential for descriptive contextualisation, categorisation and generalisability.
Exports and job creation in South Korea: industry-level analysis
Authors: Whang Unjung 
Published: November 2018

Purpose
The Korean manufacturing sector has undergone structural changes in a transition from labor- to capital-intensive industries. These changes seem to be relevant to the weakening of the export effect on employment that began in 1990. In light of the importance of exports in the Korean labor market, the purpose of this paper is to shed light on the primary reasons why export growth does not lead to sufficient job creation as it did in the past.

Design/methodology/approach
The authors first use the growth accounting approach to show that the weakening of the linkage between exports and employment is closely related to the composition of export products, which has changed toward being more labor-saving. An empirical analysis (i.e. first difference A-B generalized method of moments estimator) on the employment effect of exports confirms that as the capital-intensity of exports increases employment effect decreases.

Findings
The main findings of the study can be summarized as follows. First, the reduction in the export effect on exports is highly correlated with changes in the composition of export products. Second, an increase in exports leads to an increase in manufacturing jobs, and the export elasticity of employment decreases as capital-intensity increases. Third, the export elasticity of employment tends to be higher when the export proportion of SMEs’ products is larger.

Originality/value
Despite the many literatures on the link between exports and employment, there is no consensus on this topic. However, it is generally agreed that the employment effect of exports has been considerably weakened, compared to that of the past, at least in Korea. Nevertheless, few studies attempt to address why this trend has occurred. In this paper, we focus on the structural factors that are the major cause of the weakening of the virtuous cycle between exports and employment. This allows us to provide valuable information to policy makers who are concerned with developing export policies that are related to effective job creation.
Stakeholder value-based place brand building
Authors: Donner Mechthild , Fort Fatiha 
Published: November 2018

PurposeThe purpose of this study is to investigate the place brand building process based on multi-stakeholder perceived value. It contributes to an understanding of how place brands are developed, providing diverse benefits, and proposes a conceptual framework for place brand building and value measurement scales.Design/methodology/approachThe study is based on the place brand Sud de France. Qualitative data from stakeholder interviews is used to investigate the main place brand value dimensions. A survey of consumers from the Languedoc-Roussillon region is conducted to measure consumer place brand values. Quantitative data is analyzed using structural equation modelling.FindingsResults indicate that place brand value is a multiple-perspective and multidimensional construct that includes new measurement scales related to dimensions such as quality of life, a common local identity and local development. Brand identity is not only constructed on place identity, but should also incorporate stakeholder values and provide value to consumers.Practical implicationsFor place brand managers, this study provides a methodology that helps identify the main place image and stakeholders values to be integrated into place brand identity construction. The place brand value measurement scales can be used to ensure a permanent match between brand identity and consumption trends.Originality/valueLiterature dealing with place equity has focused mostly on country-of-origin or destination image effects from a non-local consumer or tourist perspective. The originality of this study lies in analyzing the perceived benefits of a regional brand by its local stakeholders, leading to a new brand building framework and value measurement scales.
Effect of non-uniform heat source/sink on MHD boundary layer flow and melting heat transfer of Williamson nanofluid in porous medium
Authors: Konda Jayarami Reddy , N.P. Madhusudhana Reddy , Konijeti Ramakrishna , Dasore Abhishek 
Published: November 2018

PurposeThe purpose of this paper is to examine the influence of magnetic field on Williamson nanofluid embedded in a porous medium in the presence of non-uniform heat source/sink, chemical reaction and thermal radiation effects.Design/methodology/approachThe governing physical problem is presented using the traditional Navier–Stokes theory. Consequential system of equations is transformed into a set of non-linear ordinary differential equations by means of scaling group of transformation, which are solved using the Runge–Kutta–Fehlberg method.FindingsThe working fluid is examined for several sundry parameters graphically and in a tabular form. It is noticed that with an increase in Eckert number, there is an increase in velocity and temperature along with a decrease in shear stress and heat transfer rate.Originality/valueA good agreement of the present results has been observed by comparing with the existing literature results.
Reimagining organizational storytelling research as archeological story analysis
Authors: Luhman John Teta 
Published: November 2018

PurposeWe should understand stories told in organizational settings in relation to the time, space and process of their telling. This, however, is problematic since many researchers, as a matter of habit, take organizational stories out of their context and process because they tend to collect their stories through interviews. The paper aims to discuss these issues.Design/methodology/approachIn order to accept organizational stories taken out of context and process, the author looks toward archeology and its method of interpretation of artifacts as a metaphor to guide future storytelling analysis. The author argues that storytelling researchers need the analogy of archeological interpretation of artifacts to be more convincing in their quest to discover meaning.FindingsIf one sees stories as artifacts from past utterances that are lost to the moment in which they were uttered, which the metaphor of archeology allows one to do, then the goal is to reason out a coherent narrative out of the stories collected by describing their formal attributes, their spatial attributes and their chronological inference. After which, one might fit the collected stories within the broader cultural contexts of the organization under study.Originality/valueThe author offers the idea of “archeological story analysis” as a three-step method of story analysis, which allows organizational storytelling researchers to more convincingly analyze stories collected out of their context and process. The first two steps are in the interpretation of the formal attributes and spatial attributes of the stories, while the third step (chronological inference) is an attempt to analyze storytelling intent and impact on the life of the organization.