bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineered vildagliptin-loaded polymeric nanoparticles via microfluidic and spray drying for enhanced antidiabetic activity
Authors: Kole Eknath , Jadhav Krishna , Khan Zia , Verma Rahul Kumar , Chatterjee Aniruddha , Mujumdar Arun , Naik Jitendra 
Published: November 2024

Abstract
Background
Vildagliptin (VLG), an antidiabetic agent, presents a potential solution to this widespread affliction. It exhibits notable attributes, such as a high solubility and a shorter elimination half-life. The current study uses a microreactor to fabricate sustained-release VLG-encapsulated cross-linked chitosan–dextran sulfate nanoparticles (VLG-CDNPs). The fabrication was systematically optimized using the design of experiment approach.

Results
The optimized VLG-CDNPs had an average particle size of 217.4 ± 12.3 nm and an encapsulation efficiency of 78.25 ± 3.0%. Scanning electron microscopy revealed that the nanoparticles had a smooth spherical shape. Spray drying was used for drying, and the reconstitution ability was close to ideal (~ 1.33). In vitro studies revealed sustained VLG release over 12 h, with ~ 58% in acidic and ~ 83% in basic conditions. Cell viability remained at 80% even at 100 μg/mL, and glucose uptake in L6 cells was significantly enhanced with VLG-CDNPs (78.34%) compared to pure VLG (60.91%). VLG-CDNPs also showed moderate inhibitory activity against α-amylase (41.57%) and α-glucosidase (63.48%) compared to pure VLG, which had higher inhibition levels.

Conclusion
The study’s outcome suggested that the optimized VLG-CDNPs may serve as an effective and promising nanoformulation for managing diabetes mellitus.
Telespectador fiel
Authors: Nascimento dos Santos Alliston Fellipe , Barreto Malta Renata 
Published: November 2024

Este trabalho apresenta um estudo qualitativo, de caráter exploratório, dos motivos que levam a audiência a se interessar pelas telenovelas bíblicas da Record TV. O objetivo é compreender as motivações que levam dois grupos de receptores a acompanharem esses produtos televisivos: 1- cristãs institucionalizadas; 2- pessoas que acreditam nos dogmas cristãos, mas não frequentam a igreja. Os pressupostos metodológicos fundamentam-se nos Usos e Gratificações, com entrevistas em profundidade com telespectadores das telenovelas bíblicas. Como resultado, observamos que o primeiro grupo é gratificado pelo conteúdo cristão; pela integração social/familiar e por se sentir em uma viagem ao passado. O segundo grupo é gratificado pela aprendizagem; pelo alívio do estresse e também viagem ao passado.
Spatial model of international tourism and tourists' original motives
Authors: Korol Oleksandr , Skutar Tetiana 
Published: November 2024

Properties of geographical space essentially important for international tourism, such as length and discreteness, are analyzed. Apperception of geographical space in usual environment and its effect on tourist’s original motives are described. Original motives for tourism, in particular, those of escaping, comfort, contrast and aesthetics are substantiated. Finally, upon consideration of spatial specificities of land surface and tourist-driving original motives, a conceptual model of formation and distribution of international tourism flows in geographical space is developed. The ontological-anthropologic substantiation of tarrying in usual environment and original motives for tourism has also been presented. The latter grounded on M. Heidegger’s philosophy and was an attempt to understand how Human Being exists as tourist.
Evolution and Research Trends in Physical Culture. A Longitudinal Analysis of Student Diploma Theses from the Didactic Team of Physical Culture Sciences, formerly the Department of Physical Culture, Faculty of Earth Sciences and Spatial Management, 2017-2024
Authors: Hagner-Derengowska Magdalena , Michalska Anna , Muszkieta Radosław , Smoleńska Olga , Zukow Walery 
Published: November 2024

Objective: The aim of this study was to conduct a comprehensive analysis of diploma theses produced in the Department of Physical Culture at the Faculty of Earth Sciences and Spatial Management between 2017-2024, to identify main research trends, thematic evolution, and assess the impact of external factors on research directions in the field of physical culture.
Material and Methods: The analysis included 95 diploma theses (82 bachelor's and 13 master's). Mixed research methods were applied, combining quantitative and qualitative analysis. Content analysis, statistical analysis (including chi-square tests, analysis of variance, linear regression), and advanced data analysis methods (LDA topic modeling, social network analysis, SARIMA time series analysis) were conducted. Additionally, measures of thematic diversity and supervisor specialization indicators were applied.
Results: A statistically significant upward trend in the number of theses (β = 1.1875, p = 0.0134) and significant seasonality of defenses were found. Five main thematic areas were identified: physical activity and health (29.5%), tourism (23.2%), sport (21.1%), health (15.8%), and recreation (10.5%). LDA analysis revealed more detailed categories, indicating growing interdisciplinarity of research. A significant impact of the COVID-19 pandemic on thesis topics was observed in 2020-2021. Social network analysis showed a key role of certain supervisors in shaping research directions (highest eigenvector centrality = 1.00).
Conclusions: The study revealed dynamic development of the physical culture discipline, with growing emphasis on interdisciplinarity and health aspects. Adaptation of research topics to current social and technological challenges was observed. Results indicate the need for further expansion of the thematic scope of theses, particularly in areas of new technologies and long-term effects of physical activity. The analysis provides valuable information for strategic planning of study program development and research directions in the field of physical culture, tourism, and recreation.
Response surface methodology-based optimization of hairy roots cultures for in vitro AM production
Authors: PV Priya , Kumutha K , Subhashini R , Renuka R , Sivakumar T , Kannan P 
Published: November 2024

Arbuscular mycorrhizal fungi can do wonders in promoting the crop growth as well maintaining soil health. In vitro root organ culture technology is an exciting avenue for AM biofertilizer production. This study aims to optimize the key influencing factors for enhancing the hairy root production used for in vitro AMF culturing using response surface methodology, a statistical and mathematical tool used for designing optimization studies. Study uses Rhizobium rhizogenes MTCC 2364 for transformation in carrot explant. Factors considered for optimization are concentration of gelling agent (phytagel), carbon source (sucrose) and pH of the Modified Strullu and Romand medium (MSR). Design Expert software uses second order polynomial regression equation for predicting the outcome of each experiment. Totally, 17 experiments were run following Box-Behnken design and average hairy root length and average side branch emergence were taken as response. ANOVA analysis reveals that the concentration of phytagel and sucrose had a strong influence on root length, while the phytagel and pH of the medium had a strong effect on side branch emergence. Overall, taking into account the both responses, concentration of phytagel had a significant impact on hairy root production. The maximum average hairy root length obtained was 1.12 cm and number of side branches emerged were 6.78 per day. Based on these results, the optimal parameters were MSR medium with 3gL-1 phytagel, 11gL-1 sucrose and a pH of 4 for boosting hairy root development. This study is a cost-effective approach and minimizes the time taken for establishing the hairy root technology.
Distributed cognition in oral poetry improvisation: a semiosis-centered approach
Authors: Atã Pedro , Queiroz João 
Published: November 2024

Abstract
We propose a semiotic externalist approach that takes cognition as semiosis, gives central importance to the notion of temporal distribution, describes the elements of distributed cognitive systems (DCSs) as signs, and identifies the DCS itself as a system that enacts a sign. This is a semiosis-centered, and thus a non-agent-centered account of DCSs. In order to develop and illustrate our argument, we describe an example of DCS – the Brazilian verbo-musical improvisational tradition of repente – considering it first as embodiment of the formal structure of a cognitive task, and then as embodiment of a semiotic process. The latter corresponds to a semiotization of the description of repente sessions as DCSs, that focuses on how the DCS can embody a meta semiotic process, semiosis that supervenes on, and determines, distinct types of smaller-scale semiotic process.
Externalization of the mind in the meaning-making process: An integrated semiotic and cognitive science perspective
Authors: Magnani Lorenzo , Biglari Amir 
Published: November 2024

Abstract
This article seeks to outline the effective integration of semiotic methods, particularly the Peircean approach, with research on human creative cognition. The aim is to elucidate the involvement of the mind and neurological mechanisms in the process of semiosis. By examining how the mind externalizes thoughts and ideas, the article offers a fresh perspective on how external models and representations serve as essential anchors of meaning. Furthermore, this integrated approach provides a deeper understanding of how meaning is constructed and communicated, highlighting the importance of considering both internal cognitive processes and external manifestations in the study of semiotics.
Image modeling algorithm for environment design based on augmented and virtual reality technologies
Authors: Gong Da , Chen Tong , Zhou Shuxin , Han Jiaheng , Li Zhenghang 
Published: November 2024

Abstract
With the continuous development of computer vision technology, the image modeling of environmental design has also received more and more attention. This study proposed an image modeling algorithm for environment design based on augmented reality (AR) and virtual reality (VR) technologies. On the system architecture, the environment design image modeling algorithm based on AR and VR technologies has provided users with an immersive 3D simulation space environment. It also has provided users with a good interactive interface through AR technology, enabling users to interact with computers in a realistic virtual three-dimensional environment and interactive operation. This study verified the algorithm from three aspects: time, authenticity, and interactivity. When facing object A, the modeling time values of the traditional environmental design image modeling method and the environmental design image modeling method proposed in this study were 12.14 and 8.72 s, respectively. The modeling authenticity reached 87.51 and 98.57%, respectively, and the interactivity reached 79.14 and 96.45%, respectively. Some columns of data have proved that the environmental design image modeling method proposed in this study was superior to the traditional environmental design image modeling method. In addition, this study also verified the system model from three aspects: stability, running smoothness, and performance loss. When the number of image modeling in the environment design was 2, the stability, running smoothness, and performance loss of the system were 99.37, 99.25 and 0.75%, respectively. The experimental data again proved that the algorithm system model proposed in this study was feasible and worthy of further application.
Applications of integrating artificial intelligence and big data: A comprehensive analysis
Authors: Almanasra Sally 
Published: November 2024

Abstract
The integration of artificial intelligence (AI) and big data technologies has the potential to revolutionize various industries, yet there are complexities and challenges associated with their implementation. This comprehensive study aims to investigate the combined impact of AI and big data on operational efficiency, precision, and security across multiple sectors. By utilizing a methodological analysis of 105 peer-reviewed articles sourced from reputable databases, we systematically explore the diverse applications, key innovations, and transformative potential of these technologies. Our findings uncover significant advancements in healthcare diagnostics, drug discovery, personalized education, and smart farming, highlighting how AI enhances big data analytics to drive notable improvements. Specifically, the study reveals the accuracy of AI in healthcare diagnostics, the efficiency of big data in drug discovery, the personalization of learning experiences through AI in education, and the sustainability advancements in agriculture through smart farming. These results underscore a substantial shift toward more sophisticated data-driven decision-making and operational processes facilitated by the integration of AI and big data. This shift addresses the initial research problem and makes a significant contribution to both academic and practical understanding of the role these technologies play in shaping the future of industry operations. The study concludes that while AI and big data integration offers substantial benefits, addressing associated challenges is crucial for maximizing their impact.
The role of neopterin in cross-talk between tumor and tumor microenvironment in hepatocellular carcinoma
Authors: Satılmış Basri , Çiçek Egemen , Karakaş Serdar , Kutlutürk Koray , Otan Emrah , Yılmaz Sezai , Şahin Tevfik Tolga 
Published: November 2024

Abstract
Neopterin is a marker of activated immune response, but its role in hepatocarcinogenesis is unknown. The present study aims to evaluate the effects of neopterin on prooncogenic/proinflammatory, apoptotic pathways, and other molecular mechanisms in HCC. We used SNU449, Huh-7, SK-Hep-1, and HepG2 cell lines. A cell viability assay was performed with different concentrations of neopterin. RT-PCR, Western blotting, transwell migration, scratch assay, and reactive oxygen species (ROS) production assays were performed at inhibition concentration 50 of neopterin, which was 40 µM for SNU449 and 80 µM for other cell lines. There were significant changes in mTOR, STAT3, PI3K, and interleukin-6 gene expressions, which were also supported by the protein expressions. Neopterin did not affect apoptosis in SNU449, while apoptosis increased by all doses of neopterin in SK-Hep-1 and HepG2. ROS production was increased in all cell lines in response to neopterin. Cell migration was reduced in SK-Hep1 and HepG2 but did not change in SNU449 and Huh-7. Our study showed that neopterin is not just a byproduct. The results suggest that neopterin may be a paracrine factor that modulates pro-inflammatory and pro-oncogenic pathways responsible for the biological behavior of HCC in a chronic inflammatory tumor microenvironment.
The Limits of Reconciliation: Achilles, Cyrus, and the Secret of Tact
Authors: Konstan David , Nieto Pura 
Published: November 2024

Abstract
This paper examines the tension between Cyrus and Cyaxares in Xenophon’s Cyropaedia, and the ways in which Cyrus succeeds in mollifying the Median king (and his maternal uncle), who is angry because Cyrus has usurped his authority. It argues that, although Cyrus has been charged with deceit in his effort to conciliate Cyaxares, in fact such dissembling is ineliminable where there is a genuine offense to another’s honor. It suggests further that the episode is a deliberate rejoinder to the conflict between Achilles and Agamemnon, as described in the Iliad, and is intended to show how properly to resolve a clash between a king and his more warlike subordinate.
ЭКОЛОГИЧЕСКИЕ ФАКТОРЫ И ДЕНИТРИФИЦИРУЮЩИЕ БАКТЕРИИ ЭПИЛИТОНА ОЗЕРА БАЙКАЛ
Authors: А.С. ГОРШКОВА , Г.В. ПОДЛЕСНАЯ , Н.А. ЖУЧЕНКО , И.В. ТИХОНОВА , М.Ю. СУСЛОВА , Ю.Р. НЕБЕСНЫХ , Е.А. ЗИМЕНС , О.И. БЕЛЫХ 
Published: November 2024

Эпилитные биопленки играют важную роль в водоемах, участвуя в круговороте питательных веществ. Денитрификация активно протекает в эпилитоне водоемов. Однако информация об экологических факторах, влияющих на данный процесс в биопленках, весьма ограниченна. В настоящей работе исследована численность культивируемых денитрифицирующих бактерий в биопленках, сформированных на каменистых субстратах, в различных районах литорали оз. Байкал. Выявлено, что основными факторами, объясняющими различия в количестве культивируемых бактерий, осуществляющих полную денитрификацию, были температура и концентрация общего азота в придонном слое воды. Показано, что меньшее количество денитрификаторов характерно для биопленок, испытывающих дефицит азота, на что указывало низкое стехиометрическое соотношение N : P в биопленках. Определено неравномерное распределение тяжелых металлов в биомассе эпилитных биопленок, что также может потенциально влиять на денитрификацию в эпилитоне оз. Байкал.
Participating in the circulation of nutrients epilithic biofilms play an important role in water bodies. Denitrification actively proceeds in the epilithon of water bodies. However, the information on environmental factors that affect the process in biofilms is still limited. The object of study in this article involves the number of cultivated denitrifying bacteria in biofilms formed on the stony substrates in different parts of Lake Baikal littoral zone. It has been found out that the main factors explaining the differences in the number of cultivated bacteria who perform complete denitrification were the temperature and the concentration of total nitrogen in shallow water. The article shows that lower amount of denitrifiers is a typical for biofilms experiencing nitrogen deficiency as indicated by the low stoichiometric N: P ratio in biofilms. An uneven distribution of heavy metals in the biomass of epilithic biofilms has been determined. It also may potentially impact denitrification in the epilithon of Lake Baikal.
ТАКСОНОМИЧЕСКОЕ РАЗНООБРАЗИЕ МИКРОБНОГО СООБЩЕСТВА В ТЕРМАЛЬНОМ ИСТОЧНИКЕ КУЧИГЕР (БАЙКАЛЬСКАЯ РИФТОВАЯ ЗОНА)
Authors: Е.В. ЛАВРЕНТЬЕВА , А.А. РАДНАГУРУЕВА , О.А. БАТУРИНА , В.В. ХАХИНОВ 
Published: November 2024

Гидрохимический и микроэлементный состав воды и донных осадков был определен в транзитной зоне смешения подземных и поверхностных вод в термальном источнике Кучигер (Байкальская рифтовая зона). Поступление химических веществ с подземными водами и высокие температуры создают благоприятные и специфические условия для развития микроорганизмов. Изучено таксономическое разнообразие микробного сообщества воды и донных осадков с использованием анализа ампликонов гена 16SрРНК . Проанализировано 107 619 нуклеотидных последовательностей, отнесенных к 211 ОТЕ. В изученных образцах воды и донных осадков доминировали бактерии, представители архей составляли 0,2-3,1 %. В микробных сообществах филум Proteobacteriaявлялся доминирующим. Субдоминантами в изученных образцах являлись филумы Firmicutes, Chloroflexi, Nitrospirae, Acetothermia и Actinobacteria, где их соотношение варьировало в зависимости от биотопа. Характерная особенность микробного сообщества в термальном источнике Кучигер - доминирование хемолитотрофных бактерий.
The hydrochemical and microelement composition of water and bot tom sediments was determined in the Kuchiger thermal spring (Baikal rift zone). The entry of chemicals with groundwater and high temperatures create favorable and specific conditions for the development of microorganisms. The taxonomic diversity of the microbial community of water and bottom sediments was studied using the analysis of 16S rRNA gene aplicons. 107619 nucleotide sequences assigned to 211 OTUs were analyzed. In the studied samples of water and bottom sediments, bacteria dominated, representatives of archaea accounted for 0.2-3.1 %. The phylum Proteobacteria dominated in microbial communities. The subdominants in the studied samples were the phyla Firmicutes, Chloroflexi, Nitrospirae, Acetothermia, and Actinobacteria, where their ratio varied depending on the biotope. A characteristic feature of the microbial community in the Kuchiger thermal spring is the dominance of chemolithotrophic bacteria.
ПАРАМЕТРЫ ОСЕННЕЙ МИГРАЦИОННОЙ ОСТАНОВКИ МОЛОДЫХ ВАРАКУШЕК (LUSCINIA SVECICA LINNAEUS, 1758) В УСЛОВИЯХ СРЕДНЕЙ ТАЙГИ В ВОСТОЧНОЙ ЧАСТИ РУССКОЙ РАВНИНЫ
Authors: Г.Л. НАКУЛ 
Published: November 2024

В 2015-2019 гг. осуществлен отлов молодых варакушек с целью определения параметров их миграционной остановки (сроки и динамика пролета, длительность миграционной остановки, линька в процессе миграции и скорость жиронакопления птиц во время миграционной остановки) в условиях таежной зоны на востоке Русской равнины. Проанализированы данные первичных и повторных отловов 272 птиц, из которых в выборку включены данные 186 самцов и 86 самок. Средняя длительность миграционной остановки для молодых варакушек составила 1,45 дня. Транзитные особи имеют жировые резервы, которые позволяют им совершать миграционные броски длительностью в среднем 4,39 ± 0,20 ч. Варакушки со средней длительностью остановки имеют скорость жиронакопления 0,04 ± 0,36 г в сутки и к моменту отлета способны совершать миграционные броски длительностью в среднем 3,89 ± 0,58 ч. Особи, которые принимают решение об остановке, незначительно теряют свои жировые запасы, уменьшая свои возможности к миграционному броску до следующего места. Значимость речных долин на востоке Русской равнины для успешной миграционной остановки до конца не выяснена, так как непонятно, обладают ли они теми необходимыми экологическими условиями, оказывающими влияние на параметры остановки мелких птиц.
In 2015-2019 catching of young bluethroats was carried out in order to determine the parameters of their migration stop in the taiga zone in the east of the Russian Plain. A total of 272 birds were analyzed, of which 186 were males and 86 were females. The average duration of the migration stop for young bluethroats was 1.45 days. Transient individuals have fat reserves that allow them to make migratory throws lasting an average of 4.39 ± 0.20 hours. Bluethroats with an average stopping time have a fat accumulation rate of 0.04 ± 0.36 g per day and by the time of departure are able to make non-stop flights lasting an average of 3.89 ± 0.58 hours. Individuals that make the decision to stop lose little of their fat reserves, reducing their ability to fly non-stop until the next stop. The significance of the river valleys in the east of the Russian Plain for a successful stopover remains open, and it has not been fully clarified whether these places have the necessary ecological conditions for the successful stopover of small birds.