bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of somatic focal amplifications on chromosome 30 in canine oral melanoma
Authors: Prouteau Anais , Chocteau Florian , de Brito Clotilde , Cadieu Edouard , Primot Aline , Botherel Nadine , Degorce Frédérique , Cornevin Laurence , Lagadic Marie A. , Cabillic Florian , de Fornel‐Thibaud Pauline , Devauchelle Patrick , Derrien Thomas , Abadie Jerome , André Catherine , Hédan Benoît 
Published: August 2019

AbstractCanine oral melanoma is the first malignancy of the oral cavity in dogs and is characterized by a local invasiveness and a high metastatic propensity. A better knowledge of genetic alterations is expected to improve management of this tumour. Copy number alterations are known characteristics of mucosal melanomas both in dogs and humans. The goal of this study was to explore the prognostic value of somatic focal amplifications on chromosomes (Canis Familiaris [CFA]) 10 and 30 in canine oral melanoma. The cohort included 73 dogs with oral melanoma confirmed by histology, removed surgically without adjuvant therapy and with a minimal follow‐up of 6 months. Epidemiological, clinical and histological data were collected and quantitative‐PCR were performed on formalin‐fixed paraffin‐embedded (FFPE) samples to identify specific focal amplifications. The 73 dogs included in the study had a median survival time of 220 days. Focal amplifications on CFA 10 and 30 were recurrent (49.3% and 50.7% of cases, respectively) and CFA 30 amplification was significantly associated with the amelanotic phenotype (P = .046) and high mitotic index (MI; P = .0039). CFA 30 amplification was also linked to poor prognosis (P = .0005). Other negative prognostic factors included gingiva location (P = .003), lymphadenomegaly (P = .026), tumour ulceration at diagnosis (P = .003), MI superior to 6 mitoses over 10 fields (P = .001) and amelanotic tumour (P = .029). In multivariate analyses using Cox proportional hazards regression, CFA 30 amplification (Hazard ratio [HR] = 2.08; P = .011), tumour location (HR = 2.20; P = .005) and histological pigmentation (HR = 1.87; P = .036) were significantly associated with shorter survival time. Focal amplification of CFA 30 is linked to an aggressive subset and constitutes a new prognostic factor.
Performing both lateral abdominal radiographs may not improve the visualization of gas in the gastric outflow tract of cats
Authors: Paradise Hayley , Gaschen Lorrie , Wanderer Mara , Liu Chin‐Chi , Granger L. Abbigail 
Published: August 2019

AbstractReports in the veterinary literature support three‐view abdominal radiographs as a standard of practice for evaluating dogs with suspected gastrointestinal (GI) diseases. The usefulness of three‐view abdominal studies has not been evaluated in cats. Images from a prospective crossover group study with 20 healthy cats, and those from a retrospective cohort study of 110 cats, were reviewed and the location and degree of gas was assessed in the gastric outflow tract. Comparisons of the frequency of luminal gas were made between the views and between cats with GI disease versus cats without and between cats having sedation versus those without. Chi‐Square analysis was performed withP < .05 being considered significant. No significant difference was found in the location and degree of luminal gas in left versus right lateral views in all cats regardless of the order in which the views were obtained or in cats with GI disease versus cats without. Cats with gastric dilation had a higher overall frequency of gas; those with dilation with homogeneous material were higher than those with dilation with heterogeneous material. A higher frequency of gas was found in sedated cats than nonsedated, but further study is needed to determine the underlying cause. Based on these findings, a three‐view abdominal study for cats as a standard of practice may not be necessary, but obtaining the additional lateral view when gastric dilation is present might allow better visualization of the pyloric antrum and duodenum.
Ability of positive and negative contrast computed tomographic peritoneography to delineate canine liver lobe fissures
Authors: Rivas Luis R. , Seiler Gabriela S. , Robertson Ian D. , Ryu Hongyu , Mathews Kyle G. 
Published: August 2019

AbstractObjectiveTo determine the efficacy of contrast peritoneography in delineating liver lobe fissures by using computed tomography (CT).Study designProspective cross‐sectional study.AnimalsCanine cadavers (n = 10).MethodsAn abdominal CT image of each cadaver was obtained under three conditions: without peritoneal contrast (precontrast), after insufflation of the peritoneal cavity with CO2 (negative contrast), and after intraperitoneal administration of iohexol (positive contrast). Images were reconstructed in three planes. Three reviewers independently scored each plane/contrast combination. Observers measured the length of each fissure in each plane. The measurable length of fissures was compared between techniques but was not compared with the actual length on cadavers.ResultsWhen assessment of all fissures was combined, measurements were obtained in 96 to 108 of 120 (80%‐90%) positive contrast studies, 56 to 96 of 120 (47%‐80%) negative contrast studies, and 12 to 32 of 120 (10%‐27%) precontrast CT images. All observers measured fissures in all planes that were approximately two times longer on positive compared with negative contrast studies and two times longer on negative contrast studies compared with CT images without contrast. Measurable fissure lengths were greater on positive contrast CT images (P < .0001) than on other CT images.ConclusionPositive contrast CT peritoneography improved the delineation of hepatic interlobar fissures in normal canine cadavers.Clinical significanceThese results justify further studies to determine the ability to locate large hepatic masses in dogs with positive CT. Positive contrast CT peritoneography may assist treatment planning in dogs with large hepatic tumors.
Gaze coordination with strides during walking in the cat
Authors: Zubair Humza N. , Chu Kevin M. I. , Johnson Justin L. , Rivers Trevor J. , Beloozerova Irina N. 
Published: August 2019

Key points
Vision plays a crucial role in guiding locomotion in complex environments, but the coordination between gaze and stride is not well understood.
The coordination of gaze shifts, fixations, constant gaze and slow gaze with strides in cats walking on different surfaces were examined.
It was found that gaze behaviours are coordinated with strides even when walking on a flat surface in the complete darkness, occurring in a sequential order during different phases of the stride.
During walking on complex surfaces, gaze behaviours are typically more tightly coordinated with strides, particularly at faster speeds, only slightly shifting in phase.
These findings indicate that the coordination of gaze behaviours with strides is not vision‐driven, but is a part of the whole body locomotion synergy; the visual environment and locomotor task modulate it. The results may be relevant to developing diagnostic tools and rehabilitation approaches for patients with locomotor deficits.
AbstractVision plays a crucial role in guiding locomotion in complex environments. However, the coordination between the gaze and stride is not well understood. We investigated this coordination in cats walking on a flat surface in darkness or light, along a horizontal ladder and on a pathway with small stones. We recorded vertical and horizontal eye movements and 3‐D head movement, and calculated where gaze intersected the walkway. The coordination of gaze shifts away from the animal, gaze shifts toward, fixations, constant gaze, and slow gaze with strides was investigated. We found that even during walking on the flat surface in the darkness, all gaze behaviours were coordinated with strides. Gaze shifts and slow gaze toward started in the beginning of each forelimb's swing and ended in its second half. Fixations peaked throughout the beginning and middle of swing. Gaze shifts away began throughout the second half of swing of each forelimb and ended when both forelimbs were in stance. Constant gaze and slow gaze away occurred in the beginning of stance. However, not every behaviour occurred during every stride. Light had a small effect. The ladder and stones typically increased the coordination and caused gaze behaviours to occur 3% earlier in the cycle. At faster speeds, the coordination was often tighter and some gaze behaviours occurred 2–16% later in the cycle. The findings indicate that the coordination of gaze with strides is not vision‐driven, but is a part of the whole body locomotion synergy; the visual environment and locomotor task modulate it.
Herpes zoster related healthcare burden and costs in immunocompromised (IC) and IC-free populations in England: an observational retrospective database analysis
Authors: Curran Desmond , Hunjan Manjit , El Ghachi Amale , El-Hahi Yassine , Bianco Veronique , Ferreira Germano 
Published: August 2019

ObjectiveIndividuals with immunocompromised (IC) conditions are at a higher risk of developing herpes zoster (HZ) than IC-free individuals. This study assessed the healthcare resource utilisation (HCRU) burden and costs, of HZ in IC and IC-free individuals ≥18 years of age (YOA).MethodsWe conducted an observational retrospective study in a cohort of IC (n=621 588) and IC-free (n=621 588) individuals, matched by age, gender and General Practitioner practice region, contributing to the Clinical Practice Research Datalink database from 2000 to 2012 and linked to the Hospital Episode Statistics inpatient data. HCRU (ie, primary and secondary care consultations, hospital inpatient stays and treatment prescriptions) was analysed from 7 days before to: (1) 30, (2) 365 days after the HZ diagnosis date for individuals with (1) HZ only (no postherpetic neuralgia (PHN)) and (2) individuals with HZ and PHN only. Healthcare costs were computed by multiplying the number of units of resources used by the unit costs, summed across all HCRU categories to obtain a total cost per subject. Values were expressed in 2014 UK pound sterling (£) and presented for HZ cases overall, stratified by age (ie, 18–49, 50–59, 60–69, 70–79 and ≥80 YOA) and IC status.ResultsThe percentage of HZ cases requiring hospitalisation was higher in IC individuals (2.7% vs 0.4% in IC and IC-free individuals aged 18–49 YOA, respectively and 9.5% vs 7.5% in IC and IC-free individuals aged ≥80 YOA, respectively). Similarly, HZ-related mean treatment costs per subject were higher in IC individuals (£189 vs £104 in IC and IC-free individuals aged 18–49 YOA, respectively and £557 vs £401 in IC and IC-free individuals aged ≥80 YOA, respectively). Costs varied considerably by IC condition.ConclusionsIndividuals with IC conditions, have a high burden of HZ, associated with an increased risk of HZ and high HZ-related healthcare costs.
Multicentre prospective cohort study of nonoperative versus operative treatment for flail chest and multiple rib fractures after blunt thoracic trauma: study protocol
Authors: Beks Reinier B , de Jong Mirjam B , Sweet Arthur , Peek Jesse , van Wageningen Bas , Tromp Tjarda , IJpma Frank , Wouters Roderick , Lansink Koen , Bemelman Mike , van Baal Mark , Hoogendoorn Jochem , Saltzherr Teun , Groenwold Rolf , Leenen Luke , Houwert Roderick Marijn 
Published: August 2019

IntroductionA trend has evolved towards rib fixation for flail chest although evidence is limited. Little is known about rib fixation for multiple rib fractures without flail chest. The aim of this study is to compare rib fixation with nonoperative treatment for both patients with flail chest and patients with multiple rib fractures.Methods and analysisIn this study protocol for a multicentre prospective cohort study, all patients with three or more rib fractures admitted to one of the five participating centres will be included. In two centres, rib fixation is performed and in three centres nonoperative treatment is the standard-of-care for flail chest or multiple rib fractures. The primary outcome measures are intensive care unit length of stay and hospital length of stay for patients with a flail chest and patients with multiple rib fractures, respectively. Propensity score matching will be used to control for potential confounding of the relation between treatment modality and length of stay. All analyses will be performed separately for patients with flail chest and patients with multiple rib fractures without flail chest.Ethics and disseminationThe regional Medical Research Ethics Committee UMC Utrecht approved a waiver of consent (reference number WAG/mb/17/024787 and METC protocol number 17–544/C). Patients will be fully informed of the purpose and procedures of the study, and signed informed consent will be obtained in agreement with the General Data Protection Regulation. Study results will be submitted for peer review publication.Trial registration numberNTR6833
Structural and functional support among US older adults with asthma: cross-Sectional associations with medication adherence
Authors: O'Conor Rachel , Hebert-Beirne Jeni , Kwasny Mary , Eldeirawi Kamal , Hasnain-Wynia Romana , Wisnivesky Juan , Wolf Michael , Federman Alex 
Published: August 2019

ObjectivesDisadvantaged older adults may benefit from social support in adhering to their medications, but the multidimensional nature of social relationships makes it difficult to identify the most relevant domain. We examined associations of structural and functional support with medication adherence among a cohort of older adults with asthma.DesignCross-sectional analysis of the Asthma Beliefs and Literacy in the Elderly cohort study.SettingOutpatient clinics in New York, New York, and Chicago, Illinois, USA.ParticipantsEnglish-speaking and Spanish-speaking older adults (≥60 years) with asthma.Outcome measuresMedication adherence was measured using dose counts from inhaler and self-report.ResultsAmong 383 participants, the mean age was 67 years, 38% identified as Hispanic, 33% identified as black, 52% reported monthly incomes ≤US$1350 and 64% demonstrated poor adherence to their asthma controller medication. Structural and functional support were weakly correlated (r=−0.15, p=0.005). In adjusted analyses, structural support was not associated with medication adherence. Participants who received infrequent functional support in managing their medications had lower odds of poor adherence according to dose counts (OR 0.51, 95% CI 0.26 to 0.98), but not when assessed via self-report (OR 0.81, 95% CI 0.44 to 1.48).ConclusionThe receipt of frequent functional support in managing medications was associated with poor adherence to asthma controller medications. Further research is needed to better understand the manner and context which functional support operates in relation to medication adherence among older adults.
Statistical projection methods for lung cancer incidence and mortality: a systematic review
Authors: Yu Xue Qin , Luo Qingwei , Hughes Suzanne , Wade Stephen , Caruana Michael , Canfell Karen , O'Connell Dianne L 
Published: August 2019

ObjectivesTo identify and summarise all studies using statistical methods to project lung cancer incidence or mortality rates more than 5 years into the future.Study typeSystematic review.MethodsWe performed a systematic literature search in multiple electronic databases to identify studies published from 1 January 1988 to 14 August 2018, which used statistical methods to project lung cancer incidence and/or mortality rates. Reference lists of relevant articles were checked for additional potentially relevant articles. We developed an organisational framework to classify methods into groups according to the type of data and the statistical models used. Included studies were critically appraised using prespecified criteria.ResultsOne hundred and one studies met the inclusion criteria; six studies used more than one statistical method. The number of studies reporting statistical projections for lung cancer increased substantially over time. Eighty-eight studies used projection methods, which did not incorporate data on smoking in the population, and 16 studies used a method which did incorporate data on smoking. Age–period–cohort models (44 studies) were the most commonly used methods, followed by other generalised linear models (35 studies). The majority of models were developed using observed rates for more than 10 years and used data that were considered to be good quality. A quarter of studies provided comparisons of fitted and observed rates. While validation by withholding the most recent observed data from the model and then comparing the projected and observed rates for the most recent period provides important information on the model’s performance, only 12 studies reported doing this.ConclusionThis systematic review provides an up-to-date summary of the statistical methods used in published lung cancer incidence or mortality projections. The assessment of the strengths of existing methods will help researchers to better apply and develop statistical methods for projecting lung cancer rates. Some of the common methods described in this review can be applied to the projection of rates for other cancer types or other non-infectious diseases.
The factors influencing the effective early career and rapid transition to a nursing specialty in differing contexts of practice: a modified Delphi consensus study
Authors: Chamberlain Diane , Hegney Desley , Harvey Clare , Knight Bruce , Garrahy Anne , Tsai Lily Pei-San 
Published: August 2019

ObjectivesThis study aimed to test and further develop the ‘Early Career and Rapid Transition to a Nursing Specialty’ (TRANSPEC) model to a nursing specialty developed from a systematic review. Semi-structured interviews of specialist clinically based nurses and a consensus Delphi study with an expert panel were used to expand and achieve consensus, agreement, reliability and stability of the model.DesignA modified Delphi, two rounds (64 and 52 Likert items) of reiterative online questionnaires and one round as a nominal group technique, was informed by qualitative thematic analysis of semi-structured interviews.Setting and participantsInterviews with 14 specialists clinical practicing registered nurses and a panel of 25 national experts participated in the Delphi study.ResultsThe interview participants experienced 14 rapid transitions and three were early career transition. The overarching themes from the preliminary model were confirmed and further expanded. These were the self (personal and professional); the transition processes (final and informal); a sense of belonging; and the overarching context of practice over a time continuum. In the Delphi, the highest rating item was ‘Specialty work colleagues respect, include, support, and accept specialist nurse on completion of transition processes’. Pre-entry was highlighted as an important time point prior to transition. All items reaching consensus were included in the final model. Cronbach α increased from 0.725 to 0.875 for the final model.ConclusionsThe TRANSPEC model is a valid and reliable evidence-based tool for use in the career pathway and development of nursing specialists. Using the Benner model ‘Novice to Expert’ after the novice incomer phase is achieved, further lifelong learning development will transform the novice specialist over time continuum.
Ethnographic study using Normalization Process Theory to understand the implementation process of infection prevention and control guidelines in Ireland
Authors: Agreli Heloise , Barry Fiona , Burton Aileen , Creedon Sile , Drennan Jonathan , Gould Dinah , May Carl R , Smiddy MP , Murphy Michael , Murphy Siobhan , Savage Eileen , Wills Teresa , Hegarty Josephine 
Published: August 2019

ObjectiveThe aim of this study was to explore how infection prevention and control (IPC) guidelines are used and understood by healthcare professionals, patients and families.DesignEthnographic study with 59 hours of non-participant observation and 57 conversational interviews. Data analysis was underpinned by the Normalization Process Theory (NPT) as a theoretical framework.SettingFour hospitals in Ireland.ParticipantsHealthcare professionals, patient and families.ResultsFive themes emerged through the analysis. Four themes provided evidence of the NPT elements (coherence, cognitive participation, collective action and reflexive monitoring). Our findings revealed the existence of a ‘dissonance between IPC guidelines and the reality of clinical practice’ (theme 1) and ‘Challenges to legitimatize guidelines’ recommendations in practice’ (theme 3). These elements contributed to ‘Symbolic implementation of IPC guidelines’ (theme 2), which was also determined by a ‘Lack of shared reflection upon IPC practices’ (theme 4) and a clinical context of ‘Workforce fragmentation, time pressure and lack of prioritization of IPC’ (theme 5).ConclusionsOur analysis identified themes that provide a comprehensive understanding of elements needed for the successful or unsuccessful implementation of IPC guidelines. Our findings suggest that implementation of IPC guidelines is regularly operationalised through the reproduction of IPC symbols, rather than through adherence to performance of the evidence-based recommendations. Our findings also provide insights into changes to make IPC guidelines that align with clinical work.
Gout and the risk of advanced chronic kidney disease in the UK health system: a national cohort study
Authors: Stack Austin G , Johnson Michelle Elizabeth , Blak Betina , Klein Alyssa , Carpenter Lewis , Morlock Robert , Maguire Andrew R , Parsons Victoria L 
Published: August 2019

ObjectiveEvaluate the association between gout and risk of advanced chronic kidney disease (CKD).DesignRetrospective matched cohort study.SettingUK Clinical Practice Research Datalink.ParticipantsThe analysis included data for 68 897 patients with gout and 554 964 matched patients without gout. Patients were aged ≥18 years, registered at UK practices, had ≥12 months of clinical data and had data linked with Hospital Episode Statistics. Patients were excluded for history of advanced CKD, juvenile gout, cancer, HIV, tumour lysis syndrome, Lesch-Nyhan syndrome or familial Mediterranean fever.Primary and secondary outcome measuresAdvanced CKD was defined as first occurrence of: (1) dialysis, kidney transplant, diagnosis of end-stage kidney disease (ESKD) or stage 5 CKD (diagnostic codes in Read system or International Classification of Diseases, Tenth Revision); (2) estimated glomerular filtration rate (eGFR) <10 mL/min/1.73 m²; (3) doubling of serum creatinine from baseline and (4) death associated with CKD.ResultsAdvanced CKD incidence was higher for patients with gout (8.54 per 1000 patient-years; 95% CI 8.26 to 8.83) versus without gout (4.08; 95% CI 4.00 to 4.16). Gout was associated with higher advanced CKD risk in both unadjusted analysis (HR, 2.00; 95% CI 1.92 to 2.07) and after adjustment (HR, 1.29; 95% CI 1.23 to 1.35). Association was strongest for ESKD (HR, 2.13; 95% CI 1.73 to 2.61) and was present for eGFR <10 mL/min/1.73 m² (HR, 1.45; 95% CI 1.30 to 1.61) and serum creatinine doubling (HR, 1.13; 95% CI 1.08 to 1.19) but not CKD-associated death (HR, 1.14; 95% CI 0.99 to 1.31). Association of gout with advanced CKD was replicated in propensity-score matched analysis (HR, 1.23; 95% CI 1.17 to 1.29) and analysis limited to patients with incident gout (HR, 1.28; 95% CI 1.22 to 1.35).ConclusionsGout is associated with elevated risk of CKD progression. Future studies should investigate whether controlling gout is protective and reduces CKD risk.