bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibrosis Mediators in the Colonic Mucosa of Acute and Healed Ulcerative Colitis
Authors: Gundersen Mona Dixon , Goll Rasmus , Fenton Christopher Graham , Anderssen Endre , Sørbye Sveinung Wergeland , Florholmen Jon Ragnar , Paulssen Ruth Hracky 
Published: October 2019

OBJECTIVES:A healed intestinal mucosa is the aim of therapy in acute ulcerative colitis (UC). Disruption of mucosal wound healing may lead to severe complications including intestinal fibrosis. This study examined mucosal gene expression in the healing process of acute UC with a special focus on known mediators of fibrosis.METHODS:Endoscopic biopsies from patients with acute, moderate to severe UC were analyzed with a quantitative polymerase chain reaction array for 84 genes involved in fibrosis pathways. All patients were treated with infliximab (anti– tumor necrosis factor). Biopsies were taken before therapy and when disease remission was reached, defined as a Mayo score of ≤2, with an endoscopic subscore of 0 or 1. A healthy control group was included. Immunostaining of matrix metallopeptidase 9 and smooth muscle actin was performed.RESULTS:Mucosal biopsies from acute UC (n = 28), remission UC (n = 28), and healthy controls (n = 13) were analyzed. Fibrosis and extracellular matrix-associated genes were upregulated in the endoscopically healed UC mucosa vs controls, with collagen type III alpha 1 chain, actin alpha 2, lysyl oxidase, TIMP metallopeptidase inhibitor 3, and caveolin 1 uniquely showing no overlap with acute disease. Pro- and antifibrotic mediators (interleukin [IL]13 receptor subunit alpha 2, IL1B, IL10, tumor necrosis factor, snail family transcriptional repressor 1, and C-C motif chemokine ligand 2) were upregulated in both acute and healed UC compared with controls. An attenuated pattern of the canonical transforming growth factor beta (TGFB) pathway was observed in acute UC and to a lesser extent in the healed mucosa, except for TGFB2, which was enhanced.DISCUSSION:The endoscopically healed mucosa of UC showed a persisting dysregulation of fibrosis-associated mediators compared with controls, including extracellular matrix remodeling, profibrotic cytokines, and TGFB signaling pathways.
Detection of old scattered windthrow using low cost resources. The case of Storm Xynthia in the Vosges Mountains, 28 February 2010
Authors: Haidu Ionel , Furtuna Paula Roxana , Lebaut Sébastien 
Published: October 2019

Abstract
Unlike the contiguous windthrows, the scattered windthrows occurring as a result of wind gusts of lower speed (100-140 km/h) than in the first case (>140 km/h) are much more difficult to detect due to their much smaller areas and due to their very large number (several hundred in the wooded Vosges Mountains). The objective of this research is to present a rapid procedure for the detection of the scattered windthrows based on low cost, Landsat type images, knowing that certain sensors cannot be accessed without significant investments. Our application is based on the study of effects caused by the Storm Xynthia in the Vosges Mountains in the North-East of France, on 28 February 2010. Thus, based on two sets of Landsat satellite images, we used the “dark object” approach and the Disturbance Index, as well as the image classification before and after the storm, resulting in a map of changes. Following the detection process, 257 scattered polygons were detected, totalling 229 ha. For validation purposes, high-resolution images and orthophotoplans taken before and after storm were used. The error matrix was calculated, achieving an overall accuracy of 86%, which confirmed the quality of our analysis and supported this procedure for detecting scattered windthrow based on low cost resources.
Multisensory perception and tactile metaphors for voice in the work of Herta Müller
Authors: Shopin Pavlo 
Published: October 2019

AbstractIn this article, I examine tactile metaphors for voice in the work of Herta Müller. I use conceptual metaphor theory and consider the process of multisensory perception to argue that tactile metaphors can activate multiple senses. Müller evokes tactile experience to reason about voice in her works. These seemingly modality-specific metaphors relate voice to more than one sensory impression. While multisensory perception enables the author to associate her characters’ voices creatively with different sensory phenomena, it simultaneously problematizes scholarly efforts to analyze metaphorical language and categorize figurative associations according to sensory modalities. In her literary works, tactile metaphors for voice appear well-established and even conventional, but Müller defamiliarizes them and foregrounds a metaphorical reading of tactile language. Since analytical reasoning about metaphors can be problematic because of multisensory perception, Müller’s works can be challenging to interpret as she focuses the reader’s attention on the figurative meaning of language.
Wolfgang Iser’s conception of indeterminacy: An integrational critique
Authors: Tam Theodore Tsz Hang 
Published: October 2019

AbstractAdopting the perspective of a “Harrisian” integrational linguist, this article identifies two conflicting ways in which Wolfgang Iser describes “indeterminacy” and its implications on the act of reading in his “reception theory”. It will be argued that while his understanding of contextualisation and recontextualisation is markedly similar to the integrational idea of the radical indeterminacy of the sign, he is not an “integrational literary theorist” since he ultimately sees literary works as comprising determinate, intersubjective segments and indeterminate links supplied by the reader. Iser’s significance for integrationism lies mainly in the directions he provides for the development of “integrational literary criticism”, the practitioners of which would be “cultured readers” who appreciate the impossibility of “correct” analyses and recognise indeterminacy as an integral part of the reading process.
Quantum defects by design
Authors: Bassett Lee C. , Alkauskas Audrius , Exarhos Annemarie L. , Fu Kai-Mei C. 
Published: October 2019

Abstract
Optically active point defects in wide-bandgap crystals are leading building blocks for quantum information technologies including quantum processors, repeaters, simulators, and sensors. Although defects and impurities are ubiquitous in all materials, select defect configurations in certain materials harbor coherent electronic and nuclear quantum states that can be optically and electronically addressed in solid-state devices, in some cases even at room temperature. Historically, the study of quantum point defects has been limited to a relatively small set of host materials and defect systems. In this article, we consider the potential for identifying defects in new materials, either to advance known applications in quantum science or to enable entirely new capabilities. We propose that, in principle, it should be possible to reverse the historical approach, which is partially based on accidental discovery, in order to design quantum defects with desired properties suitable for specific applications. We discuss the biggest obstacles on the road towards this goal, in particular those related to theoretical prediction, materials growth and processing, and experimental characterization.
Spectroscopic, Electrochemical and Quantum Chemical Studies for Adsorption Action of Polyethylene Oxide on Copper Surface in NaCl Solution
Authors: El-Haddad Mahmoud N. 
Published: October 2019

Abstract
The adsorption action of polyethylene oxide (PEO) on copper surface in 3.5 wt.% NaCl solution was tested using electrochemical frequency modulation (EFM), atomic absorption spectrometry (AAS), UV- visible spectrometry and the morphology of copper surface was investigated by attenuated total reflectance spectroscopy (ATR-FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX) techniques. Results obtained show that PEO is effective in preventing the corrosion of copper in NaCl solution. The adsorption of PEO onto copper surface was found to follow Langmuir isotherm model. ATR-FTIR, SEM and EDX spectroscopy techniques confirmed the adsorption of protective film of PEO on copper surface. Further, quantum chemical calculations were in agreement with inhibition efficiency (%I) of PEO that were obtained experimentally.
A produção escrita de artigo no contexto acadêmico: as contribuições da abordagem Sistêmico-Funcional
Authors: Dos Santos Záira Bomfante , Carvalho Flaviane Faria 
Published: October 2019

Este artigo investiga em que medida a abordagem linguística sistêmico-funcional, em interface com a sociorretórica, se aplica em textos produzidos pelas áreas de Humanidades e Ciências da Natureza e Matemática. O corpus de análise é composto por artigos acadêmicos produzidos por alunos afiliados a diferentes áreas do conhecimento matriculados em uma disciplina de pós-graduação com foco em letramento acadêmico. Os principais resultados obtidos demonstram que: a) a estratégia retórica mais expressiva nos artigos analisados é a citação de pesquisas prévias, buscando o respaldo de outros estudos relacionados com o tema investigado para desenvolverem suas próprias pesquisas; b) enquanto a área de Ciências Humanas parece valorizar a explicação dos objetivos, justificativa, relevância e escopo geral do trabalho, apontando para generalizações acerca dos resultados encontrados, as Ciências da Natureza e Matemática priorizam a avaliação das contribuições e implicações teóricas dos resultados encontrados na pesquisa para a área, bem como os impactos do estudo e aplicação dos seus resultados na realidade social.
Vaginal candidiasis among women of reproductive age in Dnipro city (Ukraine): Species spectrum of Candida and their susceptibility to antimycotics
Authors: Starishko O. M. , Voronkova Y. S. , Ostanina T. H. , Voronkova O. S. 
Published: September 2019

Candidiasis is one of the most common pathological processes, especially among women of reproductive age, especially pregnant. It can be expressed as Candida carriage and as an active form of infection. Although candidiasis is caused by opportunistic microorganisms, its effects can be quite significant, so it is necessary to treat it with the use of antimycotic drugs. In view of the spread among these microorganisms of resistance to antimicrobial drugs, the determining factor for the success of therapeutic measures, it is important to make a preliminary assessment of the susceptibility to antimycotics of strains isolated from persons with Candida carriage or active candidiasis. The aim of the research was to study the species range of fungi of the genus Candida isolated from the reproductive tract in women with dysbiosis and to study their susceptibility to antimycotics. Total of 227 samples of biological material from women aged 16 to 56 years have been investigated. Microscopic and cultural methods of detecting of fungi in the primary material were used for research. For the identification of species of Candida fungi, a polymerase chain reaction method in real-time was used. It was determined that the frequency of detection of Candida fungi in the composition of vaginal microbiome during inflammatory pathological processes was 76.7%. It was shown that the incidence of Candida carriage – 51.7% – slightly exceeded the frequency of detection of the active form of infection – 48.3%. The species spectrum of pathogens included: C. albicans (57.1%), C. krusei (12.6%), C. glabrata (19.5%) and Candida spp. (16.1%). In the case of active form of infection, C. albicans was prevalent – 64 (76.2%) cases. In the case of Candida carriage, other species were prevalent – 58 (64.4%) cases. The most effective drug against all isolates was amphotericin B – more than 87% of isolates were susceptible. The least effective drug was nystatin: less than 60% of isolates were susceptible. There is a rather high level of resistance to certain antimycotic drugs among the Candida species, which requires a prior preliminary study of the susceptibility of isolated strains to antimycotics for the purpose of choosing a rational and effective treatment scheme.
Functional Rehabilitation with an Onlay Ceramic Adhesive Restoration: Case Report
Authors: Ramírez Barrantes DDS, MSD, PhD Juan Carlos 
Published: October 2019

The objective of this article was to analyze the indications for the proper selection of Onlay adhesive ceramic restorations, providing a step-by-step clinical protocol. Biomechanical principles based on morphological considerations and geometric terms must be present for the careful preparation of Onlay-type cavities. Concepts about cavitary preparations are discussed under essential conditions in the preservation of healthy dental tissue, without compromising the functional and aesthetic results over time. The author's suggestion is to respect and follow in a timely manner each of the steps applied in this restorative clinical protocol, to improve the final outcome of the restoration.
Investigation of the Quality of Footwear produced by SMEs: Case study of Kariokor market, Nairobi
Authors: Mesa Janet W. , Onyancha Douglas O. , Sang Magut Paul K. 
Published: October 2019

The increasing economic growth in Kenya has encouraged the growth of the leather sector. Kenya in its long-term vision to become an industrialized middle-income country by 2030, has identified the key role that the leather sector will play.
There is a growing number of SMEs engaged in leather goods and footwear manufacturing around the country. A large number is involved in footwear manufacturing especially school shoes. This has been encouraged by local demand for affordable footwear. Even though production of leather footwear in the informal industry has increased over the years, the country’s local footwear has low market position both locally and internationally. The market share of the SME produced footwear has been attributed to low quality and poor workmanship of the products
A survey was carried out to assess the quality of leather shoes produced by SMEs in Kariokor market, Nairobi. Data was collected from 20 respondents who constituted owners and managers of footwear workshops to ascertain if they have adopted the use of quality standards in their footwear fabrication and if their products conform to any laid down quality standards. The survey was carried out using simple random sampling method. The findings showed that none of the SMEs had adopted the use of quality standards and none of them had adopted Kenya Bureau of Standards (KEBs) standards. As a consequence, there was no mechanism of ensuring and maintaining conformity to footwear quality. This study recommends increased sensitization of SMEs on the importance of quality standards and quality management system in shoe fabrication.
РЕЗУЛЬТАТИВНОСТЬ СДЕЛКИ ПОГЛОЩЕНИЯ ДЛЯ КОМПАНИЙ: ПРИМЕР ПОГЛОЩЕНИЯ INDESIT КОМПАНИЕЙ WHIRLPOOL
Authors: Миронова Анна Михайловна , Кондрашова Надежда Викторовна 
Published: October 2019

Цель: Статья посвящена вопросу оценки и анализа результативности сделки по поглощению компании Indesit компанией Whirlpool Обсуждение: Для достижения поставленной цели авторы воспользовались двумя основными подходами к оценке сделок слияний и поглощений: анализ изменения курса акций на рынке ценных бумаг и метод анализа финансовой отчетности. С целью сделать исследование наиболее объективным авторами так же учитывалась специфика рынка бытовой техники и особенности этих двух компаний. Учитывая приведенные выше параметры, авторами были проанализированы отчетность Whirlpool, тенденции на рынке ценных бумаг и положение компании по сравнению с основными конкурентами. Результаты: Авторами был проведен анализ результатов сделки для компании Whirlpool и была представлена оценка результативности сделки для компании-поглотителя в среднесрочном периоде после завершения сделки
ПОНЯТИЯ И ОЦЕНКА НАДЕЖНОСТИ И КАЧЕСТВА УСЛУГ ТЕРРИТОРИАЛЬНЫХ ЭЛЕКТРОСЕТЕВЫХ ОРГАНИЗАЦИЙ
Authors: Кондрашова Надежда Викторовна , Панина Ирина Викторовна , Попова Надежда Вячеславовна 
Published: October 2019

Цель: раскрыть содержание категорий «надежность» и «качество» применительно к услугам территориальных электросетевых организаций, дать рекомендации по организации оценки надежности и качества таких услуг в рамках внутреннего контроля. Обсуждение: субъекты электроэнергетики, поставляющие электроэнергию потребителям, отвечают перед ними за надежность и качество своих услуг. При организации соответствующего внутреннего контроля целесообразно установить максимально четкие атрибуты надежности и качества услуг и обеспечить регулярное вынесение оценок с позиций самих территориальных сетевых организаций и их клиентов. Результаты: дано контекстуальное определение понятия «надежность и качество услуг территориальных сетевых организаций» на основе классической модели качества сервиса А. Парасурамана, В. Зайтамл и Л. Берри; оценена применимость предписанных нормативными правовыми актами показателей собственной оценки надежности и качества услуг территориальной сетевой организации для целей эффективного внутреннего контроля; разработаны рекомендации по организации получения оценок надежности и качества услуг территориальной сетевой организации от ее клиентов.
МОДЕЛИРОВАНИЕ ВАЛЮТНОГО КУРСА РОССИИ И ЗАРУБЕЖНЫХ СТРАН
Authors: Гимадеев Сергей Андреевич , Трегуб Илона Владимировна 
Published: October 2019

Цель: Провести эконометрическое моделирование валютных курсов USD/RUB и EUR/USD с использованием метода линейной регрессии и определить значимые факторы, влияющие на валютные курсы. Обсуждение: Современная мировая экономика подвержена резким колебаниям валютных курсов. Важнейшими факторами, определяющими поведение участников валютного рынка, являются стабильность и предсказуемость валютного курса. Устойчивость валютного курса можно спрогнозировать, выявив переменные его формирующие. Одним из наиболее эффективных методов математического инструментария, позволяющим определить значимые факторы, формирующие валютный курс, является метод линейной регрессии. Следовательно, представляется необходимым определить, при воздействии каких факторов формируется валютный курс в России и зарубежных странах с использованием метода линейной регрессии. Результаты: Построены модели USD/RUB и EUR/USD с использованием линейной регрессии.
ТРАНСФОРМАЦИОННОЕ ЛИДЕРСТВО И ВОВЛЕЧЕННОСТЬ КАК ОСНОВА ЭФФЕКТИВНОГО УПРАВЛЕНИЯ
Authors: Зубарев Геннадий Александрович 
Published: October 2019

Цель: оценка содержания трансформационного лидерства и вовлеченности персонала как основы эффективного управления. Обсуждение: Вовлеченность можно рассматривать как наивысшую форму мотивации, что делает закономерным рост внимания российского менеджмента к этому показателю. Чтобы добиться состояния эмоциональной и интеллектуальной приверженности компании (вовлеченности), то одного руководства недостаточно. Необходимо вдохновляющее или трансформационное лидерство. Трансформационное лидерство увеличивает эффективность транзакционного, но не является его заменой. Важнейшим критерием европейской модели делового превосходства EFQM является "Лидерство", которое включает основные направления деятельности лидера. Результаты: обоснована необходимость использования концептуальных идей трансформационного лидерства и вовлеченности сотрудников для повышения результативности управления и деятельности организации.
Néologisme et identité : la construction néologique à travers l’expression de l’identité dans le média écrit en Algérie
Authors: MOUSSAOUI Karim , YERMECHE Ouerdia 
Published: October 2019

RÉSUMÉ. Cette étude propose d’aborder le néologisme du point de vue de l’identité dans un contexte algérien. Il s’agit d’expliquer comment les éléments identitaires et le profil identitaire algériens construisent le profil sémantique d’une lexie, puis élaborent un caractère néologique ou une reconstruction néologique. C’est une recherche réalisée à partir d’un travail de description des éléments identitaires développés dans des séquences discursives variées. Les textes portant des passages sont produits par des journalistes, ils traitent le sujet de l’identité nationale et socioculturelle algériennes dans un épisode sociopolitique marqué par des mutations à savoir le Printemps arabe. L’analyse de ces données consiste à décrire les différentes interprétations, une tâche qu’impose la sémantique du prototype ainsi que la théorie de représentation. Ce travail réalise que l’emploi d’une nouvelle lexie importée ou construite discursivement s’ouvre à une construction sémantique particulière dans un discours médiatique algérien, son sémantisme affiche, souvent, des potentialités sémantiques s’attachant fortement à l’identité sociale et nationale ainsi qu’aux contextes socioculturel et historique algériens. Enfin, l’étude met en valeur les références socioculturelles identitaires favorables à une construction néologique, et décrit un processus psycho-social actif dans la construction du sens. Mots-clés : identité, néologisme, positionnement historique, répertoire psychosocial, référence identitaire, stéréotype identitaire, stéréo-néologisme. ABSTRACT. The study proposes to approach neologism from the point of view of identity in an algerian context. It aims to explain how Algerian identity elements and identity patterns build the semantic profile of a lexicon, then elaborate a neologic character or a neological reconstruction. It is a research realized from a work of description of th identity elements developed in varied discursive sequences. The texts bearing passages are produced by journalists, they treat the subject the A lgerian national and socio-cultural identity in a socio-political episode marked by mutations namely the Arab Spring. The analysis of these data consists in describing the different interprétations, a task imposed by the semantics of the prototype as well as the théory of representation. This work realizes that the use of a new lexicon imported or constructed discursival opens to a particular semantic constructio in an Algerian media discourse, its semantism display, often, semantic potentialities strongly attaching to the social and national identity as well as the socio-cultural and historical contexts of A lgeria. Finaly, the study highlights socio-cultural identity references favorable to a neological construction, and describes an active psych-social process in the construction of meaning. Keywords: historical positioning, identity, identity référence, identity stereotype, neologism, psychosocial repertoire, stereo-neologism.