bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization and Preservation Performance of Multilayer Film with Insect Repellent and Antimicrobial Activities for Sliced Wheat Bread Packaging
Authors: Lee Jung‐Soo , Park Min A. , Yoon Chan Suk , Na Ja Hyun , Han Jaejoon 
Published: October 2019

AbstractA multilayer film containing star anise essential oil and thymol coating layers (SAEO and TH, respectively), with insect repellent and antimicrobial properties, has been developed using bar coating and adhesive lamination processes. Our previous study reported the in vitro activities of this polypropylene film (PP)/SAEO/polyethylene terephthalate film (PET)/TH/low‐density polyethylene film (LDPE) multilayer film. The current study focused on demonstrating the morphological, optical, and mechanical properties of the film, and evaluating its in vivo activities when used as a bread packaging material. The developed film was 15.03% thicker and 1.86% less transparent than the control film (without active agent coating layers: PP/PET/LDPE). While the color values of the developed film were slightly different from the control film, both films appeared similar to the naked eye. The tensile strength in the developed film was somewhat lower than that of the control film, while both films had statistically comparable values for elongation at break. During storage of sliced bread packaged in the developed film, the film both deterred insects from approaching toward and impeded the growth of microorganisms in the bread. These results suggest the potential applicability of the developed film as an active food packaging material with insect repellent and antimicrobial activities.Practical ApplicationA multilayer film incorporated with insect repellent and antimicrobial coating layers was applied in sliced wheat bread packaging. The developed film effectively inhibited approaches of stored‐product insects to packaged bread and growth of microorganisms on the bread surface. It can be used as an active food packaging material that improves the safety and shelf‐life of foods.
Local and landscape factors affecting tadpole diversity in subtropical Atlantic Forest streams
Authors: Anciutti Maria Aparecida Cristo , Bastiani Veluma Ialú Molinari De , Dal Magro Jacir , Carasek Fabio Luiz , Baldissera Ronei , Lucas Elaine Maria 
Published: October 2019

AbstractAnalysing which environmental features influence structure of communities is important to establish management and conservation priorities for regional biodiversity. In this study, we analysed the structure of amphibian larval assemblages in southern Brazilian streams and their relationships with local and landscape factors. We sampled tadpoles in 18 streams between November 2014 and February 2015. We collected pH, electric conductivity, temperature and dissolved oxygen in streams, and performed laboratory analyses to estimate metal concentrations in water samples. We collected metrics describing landscape factors, such as the land cover classification of a set of buffers around the streams. We found eight amphibian species in total. Tadpole richness was higher in streams with greater cover of agriculture in the 50 and 100 m buffers, but it was also lower in streams with greater cover of buildings in the 100 m buffer. Highest abundance was also found in streams with greater dissolved oxygen and larger areas of dams in the 250 m buffer, but it was lower in streams with larger areas of forests in the 500 m buffer. The presence of agriculture in the immediate surroundings of streams can increase richness of amphibians due to the occupation by open‐habitat species. On the other hand, the low number of rheophilic species suggests that soil use may restrict permanence of these species.Abstract in Portuguese is available with online material.
Advances in understanding the pathogenesis of graft‐versus‐host disease
Authors: Zeiser Robert 
Published: October 2019

SummaryAcute graft‐versus‐host disease (GVHD) remains a major complication after allogeneic haematopoietic stem cell transplantation (allo‐HSCT). The emergence of different immuno‐prophylaxis strategies, such as post‐transplant cyclophosphamide or anti‐thymocyteglobulin has reduced the incidence of acute GVHD in recent years. The biology of the acute GVHD we observe in the clinic may change due to the use of novel immuno‐stimulatory agents, including immune checkpoint inhibitors or anti‐neoplastic immune‐modifiers, like lenalidomide, given before or after allo‐HSCT. Here we discuss the recent advances in our understanding of acute GVHD with a focus on early events of the disease, including tissue damaging factors, innate immune cells, costimulatory pathways, immune cell signalling, immuno‐regulatory cell types, biomarkers of GVHD and regenerative approaches. New insight in the pathogenesis of acute GVHD has revealed the role of pro‐inflammatory intracellular signalling, defects in intestinal tissue regeneration and anti‐bacterial defence, as well as a reduced diversity of the microbiome, which will be the basis for the development of novel therapies.
Brentuximab vedotin for the treatment of patients with relapsed or refractory Hodgkin lymphoma after autologous stem cell transplantation
Authors: Kaloyannidis Panayotis , Hertzberg Mark , Webb Kate , Zomas Athanasios , Schrover Rudolf , Hurst Michael , Jacob Ian , Nikoglou Thalia , Connors Joseph M. 
Published: October 2019

SummaryBrentuximab vedotin (BV) is the first approved novel agent for salvage treatment of relapsed or refractory (R/R) classical Hodgkin lymphoma (cHL) after autologous stem cell transplantation (ASCT). In this study, a literature‐based analysis was undertaken to assess, via an indirect treatment comparison, the comparative efficacy of BV to salvage chemotherapy as treatment for R/R cHL patients following ASCT. This comparative effectiveness research was undertaken to support a reimbursement submission for BV to the Australian Pharmaceutical Benefits Advisory Committee. Retrospective analysis of individual patient data from four data sources demonstrated that the use of BV as first salvage treatment in cHL patients relapsing or progressing post‐ASCT achieved improvements in both clinical response and overall survival. More specifically, BV was associated with an incremental improvement of 22% in overall response rate compared to salvage chemotherapy. Five‐year overall survival and progression‐free survival rates were 92·2% [95% confidence interval (CI): 85·5–99·3%] and 32·2% (95% CI: 19·1–54·6%) respectively for BV, compared to 30·5% (95% CI: 22·2–42·0%) and 3·2% (95% CI: 1·1–8·9%) respectively for salvage chemotherapy. The encouraging results from this conservative analysis have the potential to support informed clinical management and funding decisions for the first salvage of cHL patients demonstrating recurrence after ASCT.
IgM paraprotein‐associated peripheral neuropathy: small CD20‐positive B‐cell clones may predict a monoclonal gammopathy of neurological significance and rituximab responsiveness
Authors: Chen Lucia Y. , Keddie Stephen , Lunn Michael P. , Bomsztyk Joshua , Vitsaras Evan , Gupta Rajeev , D'Sa Shirley 
Published: October 2019

SummaryIgM paraprotein‐associated peripheral neuropathy (PN) in patients without overt evidence of lymphoma is a recognised clinical entity of unknown aetiology. Interrogating the bone marrow B‐cell or plasma cell clones underlying paraproteinemic neuropathies may improve our understanding of both pathogenesis and treatment options. This retrospective observational analysis of IgM paraprotein‐associated PN identified five patients with small pathological MYD88 L265P and CD20‐positive B‐cell clones in their bone marrow using multi‐parametric flow cytometry, who have shown durable neurological response to rituximab. We posit that multi‐parametric flow cytometry may be instrumental in identifying the cellular source of the paraprotein in IgM paraprotein‐associated PN, and thus directing appropriate immunomodulatory therapy. Further understanding of these small pathological B‐cell clones may also provide additional insight into mechanisms of monoclonal gammopathy of clinical significance overall.
Management of anaemia in pre‐term infants
Authors: Saito‐Benz Maria , Flanagan Peter , Berry Mary J. 
Published: October 2019

SummaryPre‐term infants have one of the highest transfusion requirements within the hospital‐setting. The vast majority of blood transfusions performed in Neonatal Intensive Care Units (NICUs) are for medically stable pre‐term infants with anaemia of prematurity, with the aim of improving oxygen delivery to the vital organs during the crucial phase of growth and development. However, despite the frequency of transfusion in this population, the potential benefits and harms of ‘top up’ transfusion are not fully understood, leading to practice variation between clinicians, institutions and countries. Significant advances have been made in the prevention of anaemia of prematurity, with recent emphasis on optimising infants’ circulatory volume at birth via placental transfusion and preserving infants’ own blood volume through innovative minimal sampling techniques. More research is urgently needed to establish optimal transfusion thresholds for these high‐risk pre‐term infants, for whom benefits as well as adverse outcomes may have consequences that extend for decades throughout the recipients’ life‐course. In this review, we will discuss some of the consensus and controversies regarding optimal management of anaemia in pre‐term infants and highlight potential areas for future research.
Long non‐coding RNAs in cutaneous biology and proliferative skin diseases: Advances and perspectives
Authors: Tang Lipeng , Liang Yongxin , Xie Hesong , Yang Xiaozhi , Zheng Guangjuan 
Published: October 2019

AbstractAdvances in transcriptome sequencing have revealed that the genome fraction largely encodes for thousands of non‐coding RNAs. Long non‐coding RNAs (lncRNAs), which are a class of non–protein‐coding RNAs longer than approximately 200 nucleotides in length, are emerging as key epigenetic regulators of gene expression recently. Intensive studies have characterized their crucial roles in cutaneous biology and diseases. In this review, we address the promotive or suppressive effects of lncRNAs on cutaneous physiological processes. Then, we focus on the pathogenic role of dysfunctional lncRNAs in a variety of proliferative skin diseases. These evidences suggest that lncRNAs have indispensable roles in the processes of skin biology. Additionally, lncRNAs might be promising biomarkers and therapeutic targets for cutaneous disorders.
Acrolocalized variant of lichen sclerosus initially manifesting as degenerative collagenous plaques of the hands
Authors: Sánchez‐Mateos Diana Santiago , Jo‐Velasco Margarita , Alegría‐Landa Victoria , del Carmen Fariña‐Sabaris María , Requena Luis 
Published: October 2019

AbstractLichen sclerosus involving the hands is very uncommon. On the other hand, degenerative collagenous plaques of the hands is a rare condition characterized by keratotic, translucent papules in linear array, on the radial border of the hands. Histopathologically, lesions of degenerative collagenous plaques of the hands show increased collagen bundles in upper half of the dermis and dermal elastosis. We describe the clinical and histopathological progression experienced by a woman who initially presented lesions with clinical and histopathological appearance of degenerative collagenous plaques of the hands, which evolved into characteristic lichen sclerosus. We propose that some cases of the so‐called degenerative collagenous plaques of the hands may represent an acrolocalized lichen sclerosus at an early stage.
Consumer Inter‐Product Showrooming and Information Service Provision in an Omni‐Channel Supply Chain
Authors: Zhang Tao , Li Gang , Cheng T. C. Edwin , Shum Stephen 
Published: October 2019

ABSTRACTFacilitated by physical showrooms, many online first retailers have embarked on the practice of omni‐channel retailing. This offline to online mode (information delivery offline and product fulfillment online) empowers consumers’ showrooming behavior in two ways, namely, intra‐product showrooming (intra‐SR) and inter‐product showrooming (inter‐SR). As the physical showroom usually displays a partial assortment of the online products, consumer inter‐SR, i.e., the behavior of inspecting one product offline but buying a different or related product online, is critical to firms’ decisions. Moreover, inter‐SR facilitated by the retailer's omni‐channel operations changes the nature of upstream competition between manufacturers. In this article, we develop a theoretical model to investigate consumer inter‐SR behavior and the information service provision in an omni‐channel supply chain. Our main findings are as follows. First, consumer inter‐SR benefits the manufacturer whose product is displayed online exclusively but hurts the manufacturer whose product is dual‐channel displayed; inter‐SR is beneficial to the omni‐channel retailer only when the inter‐SR intensity is not too high. Second, under the service compensation contract, the dual‐channel manufacturer and the retailer can be coordinated to provide enhanced information service; the online‐exclusive manufacturer, however, may be either better off or worse off depending on the relative strengths of the utility‐increasing effect and the service‐differentiating effect of the information service enhancement. Third, the consumers located far from the showrooms are more likely to be hurt by the inter‐SR behavior and the information service compensation, while the local consumers generally benefit from them. Finally, the in‐store inventory that facilitates immediate product fulfillment has a positive impact on the retailer's information service provision.
Q&A
Authors: Pinchot Gifford , Jamieson David 
Published: October 2019

As a founder and the president of Bainbridge Graduate Institute, Pinchot III has become a force for sustainability in business and the champion of “intrapreneurs” in organizations. He comes to organization development and design from a background in the social sciences… and from blacksmithing.With a career that spans 40 years—basically two‐thirds of the history of organization development—Jamieson has consulted, taught, and written about OD while sitting on or chairing most of its major boards and organizations.
The Case for Design Consulting
Authors: Rousseau John 
Published: October 2019

After many years of working to get design a seat at the table when company development and strategy was being considered, the business world is finally taking notice.One result is that design consultancies are rapidly being snapped up as a result of corporate in‐sourcing. Does this signal a new era in the business of design?A series of acquisitions and other developments at marquee design firms led this consultant to wonder: What's in store for the business of design?
Freshwater mussels increase survival of largemouth bass (Micropterus salmoides) in drying pools
Authors: DuBose Traci P. , Ashford Kathryn , Vaughn Caryn C. 
Published: October 2019

AbstractBetween global climate change and anthropogenic water needs, freshwater systems are becoming more intermittent, stressing organisms adapted to perennial waters. Drought‐induced intermittency concentrates aquatic organisms into drying pools. These pools represent refugia from desiccation but apply other stressors, such as extreme temperatures and increased competition for dwindling resources. In the Southern United States, fishes and freshwater mussels are often concentrated together in drying pools during seasonal, summer droughts. This can result in increased competition for food among invertivorous fish, but also increased food abundance for these fish because mussels increase macroinvertebrate abundance. Further, since mussels require fish as hosts for their ectoparasitic larval phase, glochidia, competition with their host during this biologically active time is detrimental to mussels. We conducted an experiment to examine the effects of freshwater mussels on trophic resources and fish survival in drying pools. We stocked mesocosms with juvenile largemouth bass that were infected or uninfected with glochidia and tracked abiotic conditions, trophic resources and fish survival for 10 days. We found that fish survived longer in the presence of adult mussels, regardless of their infection status. We suspect that prey items supplemented by adult freshwater mussels increased the survival of fish. Thus, the presence of adult mussels and the resources that increase in their presence potentially mitigate stress to fish in “ecological crunch times.” By conserving mussels, fish populations might withstand droughts more easily.
Development of an instrument to assess oral hygiene ability in older adults: The oral hygiene ability instrument
Authors: Grönbeck Lindén Ingela , Andersson Pia , Dahlin‐Ivanoff Synneve , Gahnberg Lars , Hägglin Catharina 
Published: October 2019

AbstractObjectivesTo describe the development process of an instrument to assess the ability to manage daily oral hygiene and the cause of impaired oral hygiene. The instrument is initially aimed for use by the dental team in the ageing population.BackgroundOral hygiene is an important component of oral health. Inability to manage oral hygiene combined with other risk factors often results in poor oral health and impaired quality of life.MethodsA guideline for instrument development was used during the construction of the instrument. The method included three phases: I. planning: the purpose and target group of the instrument were determined, and a literature review and qualitative focus‐group study were conducted; II. construction: objectives were formulated, and a pool of items was built; and III. evaluation and validation, which included two pilot studies, interviews, item analyses and revision of the instrument.ResultsThe planning and construction phases resulted in an instrument with 47 items comprising three parts: (a) interview, (b) clinical examination and (c) observation of activities of daily living (oral hygiene). After two pilot studies, the instrument was found to have good content validity. Analyses of qualitative and quantitative data resulted in a reduction in the number of items to 33.ConclusionOHAI can be a valuable tool as a preventive method to identify older adults at risk of impaired oral health. However, the instrument needs further evaluation before wider use.
Frailty and oral health: Findings from the Concord Health and Ageing in Men Project
Authors: Valdez Eduardo , Wright Fredrick A. Clive , Naganathan Vasi , Milledge Kate , Blyth Fiona M. , Hirani Vasant , Le Couteur David G. , Handelsman David J. , Waite Louise M. , Cumming Robert G. 
Published: October 2019

AbstractObjectiveTo examine whether frailty in older men is associated with poorer oral health and lower levels of dental service utilisation.BackgroundPoor oral health has been associated with some frailty components. Less is known about the link between frailty and oral health outcomes.MethodsA cross‐sectional analysis. Data were collected from 601 older men with both frailty status and oral health information. Frailty was defined as meeting three or more of the Cardiovascular Health Study criteria: weight loss, weakness, exhaustion, slowness and low activity. Dental service utilisation (DSU) behaviour was collected from self‐response questionnaires and face‐to‐face interviews. Oral status (number of remaining and functional teeth, periodontal disease, active coronal decayed surface [ACDS] and self‐rated oral health [SROH]) was recorded by two oral health therapists. The association between frailty and oral health behaviour and risk markers was modelled using logistic regression.ResultsNineteen per cent of the participants were identified as frail. There were significant associations between frailty and dentition status (odds ratio [OR]: 2.49, 95% confidence interval [CI]: (1.17‐5.30), and frailty and ACDS (OR: 3.01, CI: 1.50‐6.08) but only ACDS remained significant after adjusting for confounders (adjusted OR: 2.46, CI: 1.17‐5.18). There was no association between frailty and DSU and frailty and SROH.ConclusionFrailty was independently associated with the presence of dental caries. However, DSU, SROH and other oral health markers were not significantly associated with frailty after adjusting for confounders. The prevalence of periodontal disease was high regardless of their frailty status.
The Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study: baseline participant profile
Authors: Métral M , Darling KEA , Locatelli I , Nadin I , Santos G , Brugger P , Kovari H , Cusini A , Gutbrod K , Tarr PE , Calmy A , Lecompte TD , Assal F , Monsch A , Kunze U , Stoeckle M , Schwind M , Schmid P , Pignatti R , Di Benedetto C , Du Pasquier R , Cavassini M ,   the NAMACO study group,   Swiss HIV Cohort Study
Published: October 2019

ObjectivesThe aim of the study was to examine baseline neurocognitive impairment (NCI) prevalence and factors associated with NCI among patients enrolled in the Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study.MethodsThe NAMACO study is an ongoing, prospective, longitudinal, multicentre and multilingual (German, French and Italian) study within the Swiss HIV Cohort Study. Between 1 May 2013 and 30 November 2016, 981 patients ≥ 45 years old were enrolled in the study. All underwent standardized neuropsychological (NP) assessment by neuropsychologists. NCI was diagnosed using Frascati criteria and classified as HIV‐associated or as related to other factors. Dichotomized analysis (NCI versus no NCI) and continuous analyses (based on NP test z‐score means) were performed.ResultsMost patients (942; 96.2%) had viral loads < 50 HIV‐1 RNA copies/mL. NCI was identified in 390 patients (39.8%): 263 patients (26.8%) had HIV‐associated NCI [249 patients (25.4%) had asymptomatic neurocognitive impairment (ANI)] and 127 patients (13%) had NCI attributable to other factors, mainly psychiatric disorders. There was good correlation between dichotomized and continuous analyses, with NCI associated with older age, non‐Caucasian ethnicity, shorter duration of education, unemployment and longer antiretroviral therapy duration.ConclusionsIn this large sample of aging people living with HIV with well‐controlled infection in Switzerland, baseline HIV‐associated NCI prevalence, as diagnosed after formal NP assessment, was 26.8%, with most cases being ANI. The NAMACO study data will enable longitudinal analyses within this population to examine factors affecting NCI development and course.
Freedom of association in the Bangladeshi garment industry: A policy schizophrenia in labour regulation
Authors: RAHIM Mia Mahmudur , ISLAM Sk Samidul 
Published: October 2019

AbstractThe right to freedom of association is fundamental for the establishment of labour unionism as an institution. While the Government of Bangladesh requires enabling legal provisions for unionization in its garment industry, regulation to ensure the right to freedom of association has proved ineffective in upholding labour unionism. This article highlights the need for legislation capable of drawing on the complementary skills and resources of the Government, factory owners, labour unions and global brands to secure a sustained commitment and contribution towards the socio‐economic and political dimensions of labour relations in Bangladesh's ready‐made garment industry.