bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Performance Flexible Supercapacitors Based on Ionogel Electrolyte with an Enhanced Ionic Conductivity
Authors: Kim Donggun , Kannan Padmanathan Karthick , Chung Chan‐Hwa 
Published: February 2018

AbstractAs an electrolyte, ionic liquids (ILs) have unique properties, including a wide potential window, high thermal stability, and safety. In particular, the wide potential window of ILs enables energy storage devices to possess a high energy density. In this work, ionogels were synthesized using 1‐ethyl‐3‐methylimidazolium tetrafluoroborate (EMIMBF4) and poly(hydroxyethyl methacrylate)‐co‐poly(ethylene glycol) dimethacrylate) copolymer (PHEMA‐co‐PEGDMA). The prepared ionogels were characterized and investigated for application as an electrolyte in all‐solid‐state supercapacitors. The ionogel electrolytes offer free‐standing films without any supporting substrate. An increment of the ionic conductivity was observed when the ionogel was prepared with a filler‐added copolymer network. The all‐solid‐state supercapacitors fabricated with these ionogels exhibited excellent performance under various bending conditions. Moreover, the specific capacitance retention was about 91% after 3,500 cycles, which demonstrates long‐term stability.
Solvent‐Free Synthesis of 1D Cancrinite Zeolite for Unexpectedly Improved Gasoline Selectivity
Authors: Cheng Shilin , Zhang Guihua , Javed Mudassar , Gao Weizhe , Mazonde Brighton , Zhang Yu , Lu Chengxue , Yang Ruiqin , Xing Chuang 
Published: February 2018

AbstractZeolites as a kind of representative solid acid material, owning unique microporous channels, could be proposed as reasonable candidate muti‐funcational catalysts on oriented synthesis of target products from syngas. This paper represents a novel way for the synthesis of cancrinite zeolite (CAN‐topology) using a solvent‐free strategy. Thus prepared CAN zeolite loaded Co‐based catalyst exhibited a remarkable catalytic performance for direct gasoline synthesis from syngas, producing unexpected gasoline selectivity with 78.3%. The amazing result was attributed to CAN zeolite with a straight channel (12MR, 1‐dimension), leading that Fischer‐Tropsch primary products could continuously and quickly diffuse in its channels. Moreover, a lack of shape selective behavior and weak acidity on CAN zeolite exhibited low isoparaffin selectivity. The Na+ content in CAN zeolite was also an important factor for tuning the product distribution. As expected, the green and facile solvent‐free approach for constructed CAN zeolite will play a vital application in selective conversion of syngas in the future.
Synthesis and DNA‐Binding Studies of A New Cyclic Dimeric Symmetrical Pseudo‐Turn Mimetic
Authors: Banerji Biswadip , Chatterjee Satadru , Killi Sunil Kumar , Srinivas D. , Prodhan Chandraday , Katarkar Atul , Chaudhuri Keya 
Published: February 2018

AbstractA new dimeric cyclic 24 member symmetrical turn analogue was synthesized efficiently by an intramolecular Heck reaction. This facile reaction has produced selectively a single dimeric product having two sets of intramolecular hydrogen bonds (IHB) at the two ends of it. Different experimental studies have unambiguously proved the presence of a pseudo‐turn like structure. Furthermore, it was shown that this molecule binds to the minor groove of DNA just like a known minor groove binder, DAPI (4′,6‐diamidino‐2‐phenylindole).
Efficacious and Selective Oxidation of Atrazine with Hydrogen Peroxide Catalyzed by Magnetite Nanoparticles: Influence of Reaction Media
Authors: Kumari Pratibha , Kumar Sanjay , Gupta Shilpi , Mishra Avinash , Kumar Arun 
Published: February 2018

AbstractAn efficient catalytic system has been developed for the oxidation of atrazine with hydrogen peroxide catalyzed by magnetite (Fe3O4) nanoparticles in organic solvents as well as in ionic liquids to yield N‐dealkylated products selectively. The superior oxidation efficacy and regioselectivity was observed in neutral and non‐coordinating ionic liquid [bmim][PF6].
ZnO Nanopillar Coated Surfaces with Substrate‐Dependent Superbactericidal Property
Authors: Yi Guangshun , Yuan Yuan , Li Xiukai , Zhang Yugen 
Published: February 2018

AbstractZnO nanopillars coated on various surfaces are able to kill adhered bacteria and fungi due to their physical structure through a rupturing mechanism. Remarkably, zinc foil and galvanized steel surfaces with ZnO nanopillar coatings demonstrate an excellent remote bacteria‐killing property. Their bacterial killing efficacy is several orders higher than ZnO nanopillars coated on other surfaces as well as ZnO nanoparticles themselves. Mechanistic study shows that the nanostructure surface kills adhered microbial cells by rupturing the cell wall, while superoxide (•O2−) released from the ZnO coating with electrons donated from zinc via the Zn/ZnO interface rather than photoirritation is responsible for the superior remote killing. The results of this study represent a novel mechanism of surface disinfection and its application in water disinfection is also demonstrated.
Nanomaterial Preparation by Extrusion through Nanoporous Membranes
Authors: Guo Peng , Huang Jing , Zhao Yaping , Martin Charles R. , Zare Richard N. , Moses Marsha A. 
Published: February 2018

AbstractTemplate synthesis represents an important class of nanofabrication methods. Herein, recent advances in nanomaterial preparation by extrusion through nanoporous membranes that preserve the template membrane without sacrificing it, which is termed as “non‐sacrificing template synthesis,” are reviewed. First, the types of nanoporous membranes used in nanoporous membrane extrusion applications are introduced. Next, four common nanoporous membrane extrusion strategies: vesicle extrusion, membrane emulsification, precipitation extrusion, and biological membrane extrusion, are examined. These methods have been utilized to prepare a wide range of nanomaterials, including liposomes, emulsions, nanoparticles, nanofibers, and nanotubes. The principle and historical context of each specific technology are discussed, presenting prominent examples and evaluating their positive and negative features. Finally, the current challenges and future opportunities of nanoporous membrane extrusion methods are discussed.
Exploration of Antigen Induced CaCO3 Nanoparticles for Therapeutic Vaccine
Authors: Wang Shuang , Ni Dezhi , Yue Hua , Luo Nana , Xi Xiaobo , Wang Yugang , Shi Min , Wei Wei , Ma Guanghui 
Published: February 2018

AbstractTherapeutic vaccines possess particular advantages and show promising potential to combat burdening diseases, such as acquired immunodeficiency syndrome, hepatitis, and even cancers. An efficient therapeutic vaccine would strengthen the immune system and eventually eliminate target cells through cytotoxic T lymphocytes (CTLs). Unfortunately, insufficient efficacy in triggering such an adaptive immune response is a problem that remains unsolved. To achieve efficient cellular immunity, antigen‐presenting cells must capture and further cross‐present disease‐associated antigens to CD8 T cells via major histocompatibility complex I molecules. Here, a biomimetic strategy is developed to fabricate hierarchical ovalbumin@CaCO3 nanoparticles (OVA@NP, ≈500 nm) under the templating effect of antigen OVA. Taking advantage of the unique physicochemical properties of crystalline vaterite, cluster structure, and high loading, OVA@NP can efficiently ferry cargo antigen to dendritic cells and blast lysosomes for antigen escape to the cytoplasm. In addition, the first evidence that the physical stress from generated CO2 induces autophagy through the LC3/Beclin 1 pathways is presented. These outcomes cooperatively promote antigen cross‐presentation, elicit CD8 T cell proliferation, ignite a potent and specific CTL response, and finally achieve prominent tumor therapy effects.
Characterization of Sea Lamprey Stream Entry Using Dual‐Frequency Identification Sonar
Authors: McCann Erin L. , Johnson Nicholas S. , Hrodey Peter J. , Pangle Kevin L. 
Published: February 2018

AbstractEffective methods to control invasive Sea Lampreys Petromyzon marinus in the Laurentian Great Lakes often rely on knowledge of the timing of the Sea Lamprey spawning migration, which has previously been characterized using data gathered from traps. Most assessment traps are located many kilometers upstream from the river mouth, so less is known about when Sea Lampreys enter spawning streams and which environmental cues trigger their transition from lakes to rivers. To decide how to develop barriers and traps that target Sea Lampreys when they enter a stream, the stream entry of Sea Lampreys into a Lake Huron tributary during 2 years was assessed using dual‐frequency identification sonar (DIDSON). Sea Lampreys entered the stream in low densities when temperatures first reached 4°C, which was up to 6 weeks and a mean of 4 weeks earlier than when they were first captured in traps located upstream. The probability of stream entry was significantly affected by stream temperature and discharge, and stream entry timing peaked when stream temperatures rose to 12°C and discharge was high. Examination of the entry at a finer temporal resolution (i.e., minutes) indicated that Sea Lampreys did not exhibit social behavior (e.g., shoaling) during stream entry. Our findings indicate that Sea Lampreys may be vulnerable to alternative trap types near river mouths and hydraulic challenges associated with traditional traps. Also, seasonal migration barriers near stream mouths may need to be installed soon after ice‐out to effectively block the entire adult Sea Lamprey cohort from upstream spawning habitat.
Pessary for prevention of preterm birth in twin pregnancy with short cervix: 3‐year follow‐up study
Authors: van ‘t Hooft J. , van der Lee J. H. , Opmeer B. C. , van Wassenaer‐Leemhuis A. G. , van Baar A. L. , Bekedam D. J. , Steenis L. J. P. , Liem S. , Schuit E. , Cuijpers C. , Bleeker E. , Vinke M. E. , Simons N. , de Graaf I. M. , Mol B. W. J. , van de Beek C. 
Published: February 2018

AbstractObjectiveA recent randomized clinical trial (ProTWIN) showed that a cervical pessary prevented preterm birth and improved neonatal outcome in women with multiple pregnancy and cervical length (CL) < 38 mm. In this follow‐up study, the long‐term developmental outcome of these children was evaluated at 3 years' corrected age.MethodsThis was a follow‐up study of ProTWIN, a multicenter trial conducted between 2009 and 2012 in which asymptomatic women with a multiple pregnancy were randomized to placement of a cervical pessary or no intervention. Current follow‐up and analysis were limited to mothers with a mid‐trimester CL < 38 mm (78 women (157 children) in the pessary group and 55 women (111 children) in the control group). At 3 years of corrected age, surviving children were invited for a Bayley Scales of Infant and Toddler Development‐third edition (Bayley‐III) assessment. Death after randomization or neurodevelopmental disability (Bayley‐III score of ≤ 85, 1 SD below mean) rates were compared between the pessary and control groups, according to the intention‐to‐treat principle and using multiple imputation for missing data. Mean Bayley‐III scores in surviving children were also assessed. A linear mixed‐effects model was used to adjust for correlation between children of one mother.ResultsFrom the time of entry in the ProTWIN trial until follow‐up at 3 years of age, a total of 27 children had died (six (5%) in the pessary vs 21 (26%) in the control group; odds ratio (OR), 0.13; 95% CI, 0.04–0.48). Bayley‐III outcomes were collected for 173/241 (72%) surviving children (114 (75%) in the pessary vs 59 (66%) in the control group). The cumulative incidence of death or survival with a neurodevelopmental disability was 12 (10%) in the pessary vs 23 (29%) in the control group (OR, 0.26; 95% CI, 0.09–0.73). No statistical or clinically relevant differences were found with respect to cognitive, language and motor development among surviving children between the groups. Comparable results were found after multiple imputation.ConclusionIn women with twin pregnancy and a CL < 38 mm, the use of a cervical pessary strongly improved survival of the children without affecting neurodevelopment at 3 years' corrected age. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.
Impacts of Global Warming on Energy Use for Heating and Cooling with Full Rebound Effects in Switzerland
Authors: Gonseth Camille , Thalmann Philippe , Vielle Marc 
Published: February 2018

SummaryThis paper analyzes the impacts of the modified needs for space heating and cooling due to global warming on the quantities of energy used for space conditioning and overall. It thereby estimates direct and total rebound effects, the latter including changes in consumption and production triggered by changes in energy needs for space conditioning by households, services and industry. A computable general equilibrium model is used to simulate a range of climate and impacts scenarios for Switzerland over the period 2010–2060. We find significant welfare gains from reduced heating needs, exceeding largely the costs of the additional electricity needed for cooling. We also find large rebound effects. For instance, while the climate scenario A1b would allow households to reduce their consumption of fossil energy for room heating by 15.9 %, actual reductions are only 10.4%, which implies a direct rebound effect of 35 %. Economy wide, fossil energy consumption could decrease by 4.3% but does so only by 2.7%, which represents a total rebound effect of 37%.
Halo Formation During Solidification of Refractory Metal Aluminide Ternary Systems
Authors: D’Souza N. , Feitosa L. M. , West G. D. , Dong H. B. 
Published: February 2018

Abstract
The evolution of eutectic morphologies following primary solidification has been studied in the refractory metal aluminide (Ta-Al-Fe, Nb-Al-Co, and Nb-Al-Fe) ternary systems. The undercooling accompanying solid growth, as related to the extended solute solubility in the primary and secondary phases can be used to account for the evolution of phase morphologies during ternary eutectic solidification. For small undercooling, the conditions of interfacial equilibrium remain valid, while in the case of significant undercooling when nucleation constraints occur, there is a departure from equilibrium leading to unexpected phases. In Ta-Al-Fe, an extended solubility of Fe in σ was observed, which was consistent with the formation of a halo of μ phase on primary σ. In Nb-Al-Co, a halo of C14 is formed on primary CoAl, but very limited vice versa. However, in the absence of a solidus projection it was not possible to definitively determine the extended solute solubility in the primary phase. In Nb-Al-Fe when nucleation constraints arise, the inability to initiate coupled growth of NbAl3 + C14 leads to the occurrence of a two-phase halo of C14 + Nb2Al, indicating a large undercooling and departure from equilibrium.
Pregnancy-associated spontaneous coronary artery dissection (PASCAD): An etiology for chest pain in the young peripartum patient
Authors: Lee Richard , Carr David 
Published: February 2018

AbstractCardiac emergencies in pregnancy and the postpartum period are rare but often life-threatening. An emergency physician’s differential diagnosis for chest pain in the peripartum patient often includes serious etiologies such as pulmonary embolism or myocardial infarction (MI). A lesser-known but important consideration on the differential for MI is that of a spontaneous coronary artery dissection (SCAD). SCAD is defined as an intramural hematoma within the coronary artery that compresses the true lumen. Expansion by increased pressures may lead to subsequent myocardial ischemia and infarction. This condition is the most common cause of pregnancy-associated MI and is reported as the cause of MI in 24% to 35% of all women younger than 50 years. This condition is predominately seen in young healthy females with no traditional risk factors for coronary artery or cardiac disease, and typically in the postpartum period. SCAD in the peripartum period is defined as pregnancy-associated spontaneous coronary artery dissection (PASCAD). Abnormal ECG changes, elevated troponins, and regional wall motional abnormalities on echocardiography are all diagnostic findings of SCAD, which can be ultimately confirmed with coronary angiography. Failure to immediately address this condition can lead to acute heart failure, cardiogenic shock, and death. Thrombolytic treatment may be harmful and is not recommended, and percutaneous coronary intervention can result in the iatrogenic propagation of further coronary dissection. As a result, the management for suspected SCAD involves emphasis on urgent transfer and urgent coronary artery angiography to determine appropriate treatment modalities.
A new surgical procedure for type II total anomalous pulmonary venous drainage
Authors: Nakanishi Keisuke , Kawasaki Shiori , Amano Atsushi 
Published: February 2018

AbstractWe report two cases of successful surgical repair of total anomalous pulmonary venous drainage. Our new surgical procedure for type IIa and IIb total anomalous pulmonary venous drainage has more advantages than the conventional rerouting method using an artificial or native pericardial patch.
PU.1/microRNA-142-3p targets ATG5/ATG16L1 to inactivate autophagy and sensitize hepatocellular carcinoma cells to sorafenib
Authors: Zhang Kai , Chen Jing , Zhou Hao , Chen Ying , Zhi Yingru , Zhang Bei , Chen Longbang , Chu Xiaoyuan , Wang Rui , Zhang Chunni 
Published: February 2018

AbstractSorafenib is currently the only systemic agent approved for treatment of advanced hepatocellular carcinoma (HCC). However, intrinsic and acquired resistance to sorafenib remains a great challenge with respect to improving the prognoses of patients with HCC. The cyto-protective functions of autophagy have been suggested as a potential mechanism by which chemoresistance or targeted drug resistance occurs in tumour cells. In the present study, miR-142-3p was identified as a novel autophagy-regulating microRNA (miRNA) that plays a vital role in sorafenib resistance in HCC cells. Gain- and loss-of-function assays revealed that ectopic miR-142-3p upregulation sensitized HCC cells to sorafenib by reducing sorafenib-induced autophagy, enhancing sorafenib-induced apoptosis and inhibiting cell growth, whereas miR-142-3p inhibition exerted contrasting effects. Bioinformatics analysis and luciferase reporter and rescue assays showed that autophagy-related 5 (ATG5) and autophagy-related 16-like 1 (ATG16L1) are potential targets through which miR-142-3p regulates autophagy inhibition. Furthermore, we verified that PU.1 regulated the expression of miR-142-3p in conjunction with our cellular experiments and the related results in the literature. Our findings show that targeting the PU.1–miR-142-3p–ATG5/ATG16L1 axis may be a useful therapeutic strategy for preventing cyto-protective autophagy to overcome sorafenib resistance.
Warm Arctic episodes linked with increased frequency of extreme winter weather in the United States
Authors: Cohen Judah , Pfeiffer Karl , Francis Jennifer A. 
Published: February 2018

AbstractRecent boreal winters have exhibited a large-scale seesaw temperature pattern characterized by an unusually warm Arctic and cold continents. Whether there is any physical link between Arctic variability and Northern Hemisphere (NH) extreme weather is an active area of research. Using a recently developed index of severe winter weather, we show that the occurrence of severe winter weather in the United States is significantly related to anomalies in pan-Arctic geopotential heights and temperatures. As the Arctic transitions from a relatively cold state to a warmer one, the frequency of severe winter weather in mid-latitudes increases through the transition. However, this relationship is strongest in the eastern US and mixed to even opposite along the western US. We also show that during mid-winter to late-winter of recent decades, when the Arctic warming trend is greatest and extends into the upper troposphere and lower stratosphere, severe winter weather—including both cold spells and heavy snows—became more frequent in the eastern United States.
Single cell polarity in liquid phase facilitates tumour metastasis
Authors: Lorentzen Anna , Becker Paul F. , Kosla Jan , Saini Massimo , Weidele Kathrin , Ronchi Paolo , Klein Corinna , Wolf Monika J. , Geist Felix , Seubert Bastian , Ringelhan Marc , Mihic-Probst Daniela , Esser Knud , Roblek Marko , Kuehne Felix , Bianco Gaia , O’Connor Tracy , Müller Quentin , Schuck Kathleen , Lange Sebastian , Hartmann Daniel , Spaich Saskia , Groß Olaf , Utikal Jochen , Haferkamp Sebastian , Sprick Martin R. , Damle-Vartak Amruta , Hapfelmeier Alexander , Hüser Norbert , Protzer Ulrike , Trumpp Andreas , Saur Dieter , Vartak Nachiket , Klein Christoph A. , Polzer Bernhard , Borsig Lubor , Heikenwalder Mathias 
Published: February 2018

AbstractDynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of polarisation maintained by single cells in liquid phase termed single-cell (sc) polarity and investigate its role during metastasis. We demonstrate that sc polarity is an inherent feature of cells from different tumour entities that is observed in circulating tumour cells in patients. Functionally, we propose that the sc pole is directly involved in early attachment, thereby affecting adhesion, transmigration and metastasis. In vivo, the metastatic capacity of cell lines correlates with the extent of sc polarisation. By manipulating sc polarity regulators and by generic depolarisation, we show that sc polarity prior to migration affects transmigration and metastasis in vitro and in vivo.
Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
Authors: Chen Degao , Xie Jing , Fiskesund Roland , Dong Wenqian , Liang Xiaoyu , Lv Jiadi , Jin Xun , Liu Jinyan , Mo Siqi , Zhang Tianzhen , Cheng Feiran , Zhou Yabo , Zhang Huafeng , Tang Ke , Ma Jingwei , Liu Yuying , Huang Bo 
Published: February 2018

AbstractResetting tumor-associated macrophages (TAMs) is a promising strategy to ameliorate the immunosuppressive tumor microenvironment and improve innate and adaptive antitumor immunity. Here we show that chloroquine (CQ), a proven anti-malarial drug, can function as an antitumor immune modulator that switches TAMs from M2 to tumor-killing M1 phenotype. Mechanistically, CQ increases macrophage lysosomal pH, causing Ca2+ release via the lysosomal Ca2+ channel mucolipin-1 (Mcoln1), which induces the activation of p38 and NF-κB, thus polarizing TAMs to M1 phenotype. In parallel, the released Ca2+ activates transcription factor EB (TFEB), which reprograms the metabolism of TAMs from oxidative phosphorylation to glycolysis. As a result, CQ-reset macrophages ameliorate tumor immune microenvironment by decreasing immunosuppressive infiltration of myeloid-derived suppressor cells and Treg cells, thus enhancing antitumor T-cell immunity. These data illuminate a previously unrecognized antitumor mechanism of CQ, suggesting a potential new macrophage-based tumor immunotherapeutic modality.