bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histological Analysis of the Wrapping Treatment for Meniscal Horizontal Tears in Rabbits
Authors: Nakagawa Kosuke , Otsuki Shuhei , Murakami Tomohiko , Okamoto Yoshinori , Okuno Nobuhiro , Wakama Hitoshi , Sezaki Shunsuke , Ikeda Kuniaki , Okayoshi Tomohiro , Neo Masashi 
Published: August 2019

Objective To investigate meniscal regeneration and prevent cartilage degeneration using wrapping treatment for meniscal horizontal tears that have been difficult to repair in rabbits. Design Thirty knees from 15 Japanese white rabbits were divided into the horizontal (horizontal tears) or wrapping (horizontal tears with wrapping treatment) groups. Horizontal tears were created and wrapped with a sheet scaffold containing polyglycolic acid, polylactic acid, and polycaprolactone. The meniscus was stained with Safranin-O/Fast Green and evaluated with modified Pauli scores at 8, 12, and 16 weeks after implantation ( n = 5). Cell morphology was determined with hematoxylin and eosin staining. Mature collagen was confirmed with Picrosirius Red staining. Furthermore, immunohistochemical analysis of inducible nitric oxide synthase (iNOS) for inflammation, Ki-67 for proliferation, and type II collagen for regeneration was performed. Medial femoral cartilage was stained with Safranin-O/Fast Green and evaluated with the Osteoarthritis Research Society International score at 8 and 16 weeks. Results The wrapping group had significantly better regeneration than the horizontal group, especially at 16 weeks ( P < 0.05). Wrapping treatment induced fibrochondrocyte-like cells at 16 weeks. After wrapping treatment, iNOS was overexpressed at 8 weeks, Ki-67 at 8 and 12 weeks, and type II collagen at 16 weeks. Cartilage degeneration in the wrapping group did not progress significantly compared with that in the horizontal group at 16 weeks ( P < 0.05). Conclusions Wrapping treatment for meniscal horizontal tears induced meniscal regeneration as the sheet scaffold might induce intrinsic and extrinsic repair. Regaining the meniscal function by the wrapping treatment prevented cartilage degeneration.
Cost per response/remission in biologics available in Italy for the treatment of TNF-α inhibitors-naïve patients with ulcerative colitis
Authors: Ruggeri Matteo , Rolli Francesca Romana 
Published: August 2019

Objective: This study compares the cost of a sustained response or remission (at 52 weeks’ follow-up) across biologics approved in Italy for the treatment of moderately to severely active ulcerative colitis (UC), specifically among anti-TNF-α-naïve patients. The analysis is from the perspective of the national healthcare provider (SSN) for one year of treatment. Methods: Efficacy data about the induction of response/remission probabilities at 52 weeks and the number needed to treat (NNT) were derived from a network meta-analysis of randomized controlled clinical trials of the following drugs: infliximab (originator and biosimilar), adalimumab, golimumab and vedolizumab. It included the acquisition and administration costs of biologics, based on an activity-based costing analysis performed in 3 Italian centers of excellence for UC treatment. Results: The costs per patient in sustained response at 52 weeks were, in increasing order: vedolizumab €47,772 (95% CI €29,869 - €101,055), biosimilar infliximab €48,657 (95% CI €31,488 - €95,523), golimumab (100 mg every 4 weeks at maintenance) €57,940 (95% CI €38,00 - €106,206), golimumab (50 mg every 4 weeks at maintenance) €62,504 (95% CI €39,976 - €120,477), adalimumab €101,181 (95% CI €49,635 - €422,334). The costs per patient in sustained remission at 52 weeks were: vedolizumab €86,220 (95% CI €47,015 - €206,652), biosimilar infliximab €92,562 (95% CI €52,954 - €203,619). Conclusions: In patients with moderate to severe UC not previously treated with TNF-α inhibitors, treatment needed with vedolizumab to obtain a response or remission at 52 weeks of follow-up is less costly to the SSN compared with the other UC-approved biologics available in Italy.
Purpose in Life and Conscientiousness Protect Against the Development of Suicidal Ideation in U.S. Military Veterans With PTSD and MDD: Results From the National Health and Resilience in Veterans Study
Authors: Straus Elizabeth , Norman Sonya B. , Tripp Jessica C. , Pitts Michelle , Pietrzak Robert H. 
Published: August 2019

Background Although several studies have examined risk factors for suicidal ideation among veterans, little is known about risk and protective factors for suicidal ideation in high-risk veteran samples. Thus, this study examined a broad range of risk and protective factors associated with the development of suicidal ideation in a high-risk sample of U.S. veterans who screened positive for current posttraumatic stress disorder (PTSD) and/or major depressive disorder (MDD) . Methods Data were analyzed from the National Health and Resilience in Veterans Study, a nationally representative, prospective cohort study of U.S. veterans. Veterans completed self-report measures to screen for PTSD and MDD and to assess for risk and protective factors. The sample included 222 veterans with PTSD and/or MDD who did not endorse suicidal ideation at baseline and completed at least one assessment over a seven-year follow-up period. A multivariable binary logistic regression analysis was conducted to examine baseline factors associated with incident suicidal ideation. Results Nearly one in three (27.1%) of veterans with PTSD and/or MDD developed suicidal ideation over the seven-year follow-up period. Non-Caucasian race and lower scores on measures of purpose in life, conscientiousness, and frequency of religious service attendance were independently associated with incident suicidal ideation. Lower purpose in life (52.3%) and conscientiousness (33.2%) explained the vast majority of variance in incident suicidal ideation. Conclusion Nearly 30% of veterans with PTSD and/or MDD who did not endorse suicidal ideation at baseline developed suicidal ideation over a seven-year period. Prevention and treatment efforts designed to bolster purpose in life and conscientiousness may help mitigate risk for suicidal ideation in this high-risk population.
Outcomes and Practice Preferences After Endophthalmitis Following Anti-VEGF Intravitreal Injection
Authors: Chen Yicheng , Shah Gaurav K. , Shah Vaishali , Blinder Kevin J. , Jeroudi Abdallah M. , Leonard Anthony , Gilca Marina , Pollack John S. , Wang Rui , Wykoff Charles C. , Weinstock Brett M. , Regillo Carl D. , van Zyl Tave , Modjtahedi Bobeck S. , Eliott Dean , Kalevar Ananda , Jumper J. Michael , Whitted Ryan J. , Lee Gregory , Kitchens John W. , Joseph Anthony , Heier Jeffrey S. , Rostamizadeh Mahdi , Abdelaziz Musa , Singerman Lawrence J. , Hu Jonathan K. , Tewari Asheesh 
Published: August 2019

Purpose: This study examines treatment-based outcomes of endophthalmitis due to antivascular endothelial growth factor (anti-VEGF) intravitreal injection and its effect on subsequent management of neovascular disease. Methods: A retrospective multicenter study was conducted of 157 patients with a diagnosis of endophthalmitis following anti-VEGF intravitreal injection at 10 major ophthalmic centers. Results: The median number of injections before endophthalmitis was 10 (range, 1 to 84 injections). Initial treatment with tap and inject with or without subsequent vitrectomy trended toward smaller visual acuity changes from baseline (4 ETDRS [Early Treatment Diabetic Retinopathy Study] letter difference vs 19 ETDRS letter difference) compared with initial vitrectomy, but the difference was not statistically significant. There was no significant change in medication choice among injections after endophthalmitis. There was a statistically significant shift away from regular interval (1- to 2-month) injections and a shift toward treat-and-extend and as-needed injection algorithms. Conclusions: The visual outcomes were not significantly different between patients who initially underwent tap and injection of antibiotics and those who underwent vitrectomy. There was no significant change in medication choice before and after endophthalmitis but there was a shift toward lower-frequency injection algorithms after postintravitreal injection endophthalmitis compared with prior.
Sector Retinitis Pigmentosa and a Novel Rhodopsin Point Mutation—Case Series
Authors: Careba Ioana , Almuhtaseb Hussein , Gupta Bhaskar , De Salvo Gabriella 
Published: August 2019

Purpose: This article describes the clinical features and differential diagnosis of 4 cases of sector autosomal dominant (AD) retinitis pigmentosa (RP) studied with multimodal imaging, using autofluorescence (AF) imaging as a key diagnostic tool. Methods: The current study is an observational case series of 4 patients with characteristic visual field (VF) defects. Ophthalmic examination, VF testing, spectral-domain optical coherence tomography (SD-OCT), electrodiagnostic tests (EDTs), AF imaging, and genetic testing were performed in the 8 eyes of 4 patients (1 female and 3 male). Results: In all 4 cases, fundus examination revealed retinal pigment epithelial changes mainly in the inferotemporal retinal quadrant. The optic discs looked healthy, with no evidence of glaucomatous neuropathy. In each case, AF showed a bilateral, well-demarcated, leaf-like perivascular area of patchy hypoautofluorescence surrounded by a halo of hyperautofluorescence. SD-OCT over the leaf-like area confirmed that the interdigitation zone, ellipsoid zone, external limiting membrane, and outer nuclear layer were all affected. The EDT results varied among patients but confirmed involvement of both rods and cones in 1 patient. Genetic testing confirmed the diagnosis of AD-RP with a mutation in RHO c.491c>Tp.(Ala164Val) in all 3 male patients, and a new mutation c.66C>Ap.(Ser22Arg) in the female patient. Conclusions: AF is a fundamental diagnostic tool in both the diagnosis and follow-up of sector RP. We recommend that ophthalmologists perform AF as an adjunctive diagnostic test in cases of unexplained VF defects.
Smoking cessation in severe mental illness: combined long-term quit rates from the UK SCIMITAR trials programme
Authors: Gilbody Simon , Peckham Emily , Bailey Della , Arundel Catherine , Heron Paul , Crosland Suzanne , Fairhurst Caroline , Hewitt Catherine , Li Jinshuo ,   members of the SCIMITAR+ collaborative
Published: August 2019

SummarySmoking contributes to health inequalities for people with severe mental illness (SMI). Although smoking cessation interventions are effective in the short term, there are few long-term trial-based estimates of abstinence. The SCIMITAR trials programme includes the largest trial to date of a smoking cessation intervention for people with SMI, but this was underpowered to detect anticipated long-term quit rates. By pooling pilot and full-trial data we found that quit rates were maintained at 12 months (OR = 1.67, 95% CI 1.02–2.73, P = 0.04). Policymakers can now be confident that bespoke smoking cessation interventions produce successful short- and long-term quitting.
Fluid Loss during Exercise-Heat Stress Reduces Cardiac Vagal Autonomic Modulation
Authors: MACARTNEY MICHAEL J. , MEADE ROBERT D. , NOTLEY SEAN R. , HERRY CHRISTOPHE L. , SEELY ANDREW J. E. , KENNY GLEN P. 
Published: August 2019

ABSTRACT

Purpose
Sweat-induced fluid loss during prolonged exercise-heat stress can compromise cardiovascular and thermoregulatory function, although its effects on cardiac autonomic modulation remain unclear. We therefore examined heart rate variability (HRV) and recovery (HRRec), as surrogates of cardiac autonomic modulation, during and after prolonged exercise in the heat with and without fluid replacement.

Methods
Eleven young and healthy men performed 90 min of semi-recumbent cycling in dry heat (40°C; 20% relative humidity) at a fixed rate of metabolic heat production (600 W; ~46% V˙O2peak) followed by 40-min resting recovery without fluid replacement (No-FR; ~3.4% reduction in body mass). On a separate day, participants completed the same protocol with fluid replacement (FR; 500–700 mL timed boluses) to offset sweat losses. Esophageal temperature and ECG were recorded throughout, with measurements analyzed over 10-min averaged epochs during baseline, each 30-min interval during exercise and 20-min interval during recovery.

Results
Esophageal temperature and heart rate were elevated in No-FR relative to FR throughout exercise (all P ≤ 0.02). The HRV indices reflecting vagal influence of heart rate including the cardiac vagal index (CVI = log10[16 × SD1 × SD2]) and root-mean-square of successive differences were attenuated throughout exercise relative to baseline in both conditions (all P < 0.05), with the magnitude of the reduction greater in the No-FR condition (all P < 0.05). Further, sample entropy was reduced throughout all time points measured during exercise in the No-FR relative to FR condition (all P ≤ 0.03).

Conclusions
Our unique observations indicate that while prolonged exercise heat stress attenuates the vagal influence and complexity of cardiac rhythms, that reduction is further exacerbated by fluid loss, highlighting the importance of fluid replacement in such conditions.
Clinical value of a new generation adaptive statistical iterative reconstruction (ASIR-V) in the diagnosis of pulmonary nodule in low-dose chest CT
Authors: Tang Hui , Liu Zhentang , Hu Zhijun , He Taiping , Li Dou , Yu Nan , Jia Yongjun , Shi Hong 
Published: August 2019

Objective: To evaluate the clinical value of low-dose chest CT combined with the new generation adaptive statistical iterative reconstruction (ASIR-V) algorithm in the diagnosis of pulmonary nodule. Methods: 30 patients with pulmonary nodules underwent chest CT using Revolution CT. The patients were first scanned with standard-dose at a noise index (NI) of 14, and the images were reconstructed with filtered back projection (FBP) algorithm. If pulmonary nodules were found, a low-dose targeted scan, with NI of 24, was performed localized on the nodules, and the images were reconstructed with 60% ASIR-V. The detection rate of pulmonary nodules in the two scanning modes was recorded. The size of nodules, CT value and standard deviation of nodules were measured. The signal-to-noise ratio and contrast-to-noise ratio were also calculated. Two experienced radiologists used a 5-point method to score the image quality. The volumetric CT dose index, and dose–length product were recorded and the effective dose (ED) was calculated of the two scanning modes. Results: Volumetric CT dose index (ED) of the standard-dose scan covering the entire lungs was 7.29 ± 2.38 mGy (3.52 ± 1.09 mSv), and that of low-dose targeted scan was 2.56 ± 1.87 mGy (0.51 ± 0.32 mSv). However, the ED of the virtual low-dose scan for the entire lungs was 1.44 ± 0.15 mSv, which would mean a dose reduction of 59.1% compared with the standard-dose scan. 85 of the 87 pulmonary nodules were detected in the low-dose targeted scan, with 2 of the ground-glass density nodules with size less than 1 cm missed, resulting in 97.7% overall detection rate. There was no difference between the low-dose ASIR-V images and standard-dose FBP images for the size (1.49 ± 0.74 cm vs 1.48 ± 0.75 cm), CT value [33.02 ± 1.95 Hounsfield unit (HU) vs 34.6 ± 3.07 HU], standard deviation (27.64 ± 14.42 HU vs 30.38 ± 20.04 HU), signal-to-noise ratio (1.44 ± 0.88 vs 1.43 ± 1.31) and contrast-to-noise ratio (38.95 ± 18.43 vs 38.23 ± 14.99) of nodules (all p > 0.05). There was no difference in the subjective scores between the two scanning modes. Conclusion: The low-dose CT scan combined with ASIR-V algorithm is of comparable value in the detection and the display of pulmonary nodules when compared with the FBP images obtained by standard-dose scan. Advances in knowledge: This is a clinical study to evaluate the clinical value of pulmonary nodules using ASIR-V algorithm in the same patients in the low-dose chest CT scans. It suggests that ASIR-V provides similar image quality and detection rate for pulmonary nodules at much reduced radiation dose.
O projeto Erasmus: internacionalização da educação em contexto de integração | The Erasmus project: internationalization of education in the context of integration
Authors: Tostes Ana Paula Balthazar , Barros Silva Lucca Viersa 
Published: August 2019

O artigo argumenta que há um duplo impacto do programa ERASMUS na região de integração europeia através da análise dos objetivos e da importância do programa para as políticas da União Europeia. O primeiro impacto é o da internacionalização da educação, que se dá inicialmente apenas no âmbito comunitário e após a criação do ERASMUS+ em 2014 se abre para fora da região de integração. O segundo impacto pode ser verificado pelo seu potencial em funcionar como uma das políticas de consolidação de valores comuns, símbolos, cultura e identidade regional, internamente, e externamente como uma estratégia de aumento de visibilidade da União, suas políticas e significados. O artigo traz uma sistematização de dados empíricos sobre o programa e uma análise que contribui para a melhor compreensão sobre políticas de intercâmbio que promovem internacionalização do ensino e pesquisa, além da reflexão sobre métodos e iniciativas bem-sucedidas em contextos de integração regional.Palavras-chave: Erasmus, intercâmbio internacional, educação.ABSTRACTThe article argues that there is a dual impact of the ERASMUS program in the region of European integration by examining the objectives and importance of the program in the European Union's policies. The first impact is the internationalization of education, which initially only takes place at Community level and after the criation of ERASMUS+ in 2014 opens up outside the region of integration. The second impact can be verified by its potential to function as one of the policies of consolidation of common values, symbols, culture and regional identity, internally, as well as externally it has worked as a strategy of increasing visibility of the Union, its policies and meanings. The article brings a systematization of empirical data about the program and an analysis to contribute to a better understanding of exchange policies that promote internationalization of teaching and research, as well as reflection on successful methods and initiatives in a context of regional integration.Keywords: Erasmus; international exchange; education.Recebido em 26 out.2018 | Aceito em 08 ago. 2019
Editorial | Editorial
Authors: Suppo Hugo , Granja Lorena 
Published: August 2019

A Revista Mural Internacional, criada em 2010, acaba de ser promovida no ranking da avaliação da CAPES de B2 para A3. Esse reconhecimento é fruto do trabalho de uma equipe abnegada, que foi se renovando ao longo do tempo e que teve como impulsora à professora Miriam Gomes Saraiva do PPGRI. A partir deste ano, a revista conta com dois novos editores responsáveis que terão a enorme responsabilidade de dar continuidade ao excelente trabalho realizado pela sua antecessora, a professora Tatiana Oliveira e sua equipe, composta pelos professores Maurício Santoro, Lorena Granja Hernández e Danielle Costa da Silva.Dando continuidade ao processo de aperfeiçoamento da revista, a mesma será publicada anualmente, adotando o método de fluxo contínuo, segundo o qual os artigos são disponibilizados conforme seus processos de avaliação cega por pares e editoração forem sendo concluídos. Dessa forma, ao final do ano, todos os artigos são reunidos em um único número. Esse formato garante a circulação do conhecimento de maneira mais fluida acelerando o processo de comunicação das pesquisas.É importante assinalar que nesse tipo de formato já não se utiliza mais a numeração de páginas tradicional, pois todos os artigos tem um identificador eletrônico, denominado elocation-id (electronic location identifier). Trata-se de um identificador único dentro do volume, que permite a correta identificação e citação dos artigos. Ressalte-se que a revista continuará utilizando o identificador de objetos digitais, DOI (Digital Object Identifier), o que que garante a respectiva localização na rede.Além disso, a revista conta este ano com um dossiê especial, elaborado em parceria com a área de “Ensino, Pesquisa e Extensão” da ABRI - Associação Brasileira de Relações Internacionais que contou com o trabalho da equipe de colaboradores bipartite: Tatiana Oliveira (Mural), Marilia Carolina Souza Pimenta (ABRI), Hermes Moreira Junior (ABRI), Lorena Granja (Mural) e Mauricio Santoro (Mural).Por fim, nesta nova etapa de renovação da Revista Mural Internacional, contamos mais uma vez com a colaboração de nossos prestigiados pareceristas, autores e membros da equipe técnica, sem os quais ela não teria logrado êxito.Hugo R. SuppoLorena GranjaEditores-chefes Mural Internacional
Multiple Esophageal Squamous Papillomas
Authors: Makise Satoshi , Hiraka Kiyohisa , Watanabe Hirofumi , Atsumi Kazushige , Inoue Kimiyo , Miyajima Kimitaka , Makisumi Kenji , Mizushima Akira , Sasaguri Takakazu , Tsurumaru Daisuke , Honda Hiroshi 
Published: August 2019

ABSTRACT
We report a rare case of multiple esophageal squamous papillomas (ESPs). A 42-year-old man underwent a medical examination, and abnormalities of multiple elevated lesions were noted using a esophagogastroduodenoscope. He underwent upper gastrointestinal tract radiography with an orally ingested barium sulfate and gastrointestinal endoscopy, which revealed multiple elevated lesions in the esophagus, predominantly on the distal esophagus. We performed an endoscopic esophageal mucosal resection using a cap-fitted esophagogastroduodenoscope to obtain sufficient specimens. Based on the pathological findings, we diagnosed multiple ESPs. Although single ESPs or a few ESPs in a patient are often encountered, multiple ESP cases are rare.
“Una impronta di italianitá”: os livros didáticos para as escolas étnicas italianas no Brasil entre o liberalismo e o fascismo
Authors: Barausse Alberto 
Published: August 2019

Este artigo pretende investigar o processo histórico das políticas de produção dos livros escolares adotadas pela classe dirigente italiana para as escolas no exterior a fim de oferecer uma contribuição para o entendimento das dinâmicas e complexas ações que têm caracterizado e acompanhado o desenvolvimento da escolarização e dos processos culturais e formativos, sobretudo identitários, dos colonos italianos no Brasil, entre a segunda metade do século XIX e a fim dos anos 30, do século XX. Os livros didáticos foram, desde o começo da experiência da unificação italiana, um instrumento fundamental para as classes dirigentes italianas que tinham por finalidade modernizar e, sobretudo, homogeneizar e uniformizar o ensino nas escolas em sentido nacional. No curso das décadas seguintes, a produção e a circulação dos livros didáticos aumentaram significativamente também em relação ao desenvolvimento das publicações escolares. A questão assumiu uma grande importância também quando os governos italianos promoveram uma nova política de expansão colonial e de emigração de massa para o exterior. Após a aprovação da lei com a qual o governo Crispi, no ano 1889, instituiu o sistema das escolas italianas coloniais e subsidiadas, se colocou o problema de quais livros didáticos introduzir nos países que recebiam emigrantes italianos e quais características os mesmos deveriam ter. O artigo enfatiza o processo de continuidade e descontinuidade das políticas e da produção de libros didáticos introduzidos nas escolas italianas no exterior e no Brasil, em específico até a ascensão do fascismo para fomentar diferentes ideias de italianidade.