bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic Resonance‐Guided Laser Interstitial Thermal Therapy Using Dual‐Wavelength Dual‐Output Laser Within Two Probe Trajectories for Treatment of Drug‐Resistant Epilepsy
Authors: Lin Jingquan , Gao Wei , Ying Yuqi , Bakrbaldawi Ahmed Abdulsalam Ali , Zhu Zhoule , Cai Chengwei , Guo Xinxia , Zhang Jianmin , Zhu Junming 
Published: November 2024

ABSTRACTObjectiveMagnetic resonance‐guided laser interstitial thermal therapy (MRgLITT) is a novel tool and a minimally invasive treatment to drug‐resistant epilepsy (DRE). The focus of this research was to evaluate the effectiveness and safety of the newly developed dual‐wavelength dual‐output MRgLITT system LaserRO within two probe trajectories in treating DRE patients.MethodsThis is a retrospective analysis conducted at a single center, examining patients with DRE who received treatment with the LaserRO MRgLITT system. The system utilizes a sophisticated laser technology that can be configured as conventional single output for single wavelength or innovative dual outputs for dual wavelengths. The study involved a comprehensive review of patient information, encompassing demographics, seizure history, details related to the surgical parameters, and the subsequent clinical results. Primary outcome was post‐operation seizure outcome defined as Engel Scale Class at the end of follow‐up time.ResultsThis study included a total of eight DRE patients received MRgLITT surgery between August 2022 and October 2023. Out of these, there were four mesial temporal lobe epilepsy (MTLE), three focal cortical dysplasia (FCD), and one cavernous malformation (CM) patients. Within the two probe trajectories, seven patients had single wavelength (980 or 1064 nm) laser treatment and one patient had dual‐wavelength (980 and 1064 nm) laser treatment. The median age of the patients was 27 (22–31) years, with a median follow‐up period of 9.7 (8.4–12.1) months. The mean BMI was recorded at 20.24 ± 2.95 kg/m2, and epilepsy history was 13 ± 6 years. The median intraoperative blood loss was 5 (5–9) mL, operation time was 231 (169–254) minutes, and length of stay (LOS) was 3 (3–5) days. The mean ablation volume ratio was 96.52% ± 3.67%. In terms of outcomes, over a median follow‐up time of 9.7 (range 8.4–12.1) months, there were two patients got Engel I, five patients got seizure‐free, and one patient decreased 75% seizure. Importantly, no serious complications following the procedures occurred.ConclusionsThe preliminary results indicate that the MRgLITT procedure, which operates dual‐output laser with single or dual wavelengths (980/1064 nm) within the two trajectories, is both effective and safe as a minimally invasive approach for different types of DRE patients.
SLC30A4‐AS1 Mediates the Senescence of Periodontal Ligament Stem Cells in Inflammatory Environments via the Alternative Splicing of TP53BP1
Authors: Xu Mei , Gan Dian , Zhang Xi‐Yu , He Xiao‐Tao , Wu Rui Xin , Yin Yuan , Jin Rui , Li Lin , Tan Yu‐Jie , Chen Fa‐Ming , Li Xuan , Tian Bei‐Min 
Published: November 2024

ABSTRACTPeriodontal ligament stem cells (PDLSCs) are key cells that suppress periodontal damage during both the progression and recovery stages of periodontitis. Although substantial evidence has demonstrated that incubation under an inflammatory condition may accelerate senescence of PDLSCs, whether cellular senescence in response to inflammatory incubation contributes to cell dysfunction remain unexplored. In this study, we first observed inflammation‐caused PDLSC senescence in periodontitis based on comparisons of matched patients, and this cellular senescence was demonstrated in healthy cells that were subjected to inflammatory conditions. We subsequently designed further experiments to investigate the possible mechanism underlying inflammation‐induced PDLSC senescence with a particular focus on the role of long noncoding RNAs (lncRNAs). LncRNA microarray analysis and functional gain/loss studies revealed SLC30A4‐AS1 as a regulator of inflammation‐mediated PDLSC senescence. By full‐length transcriptome sequencing, we found that SLC30A4‐AS1 interacted with SRSF3 to affect the alternative splicing (AS) of TP53BP1 and alter the expression of TP53BP1‐204. Further functional studies showed that decreased expression of TP53BP1‐204 reversed PDLSC senescence, and SLC30A4‐AS1 overexpression‐induced PDLSC senescence was abolished by TP53BP1‐204 knockdown. Our data suggest for the first time that SLC30A4‐AS1 plays a key role in regulating PDLSC senescence in inflammatory environments by modulating the AS of TP53BP1.
Evolution of Linguistic Markers of Agency, Centrality and Content During Metacognitive Therapy for Psychosis: A Pilot Exploratory Study
Authors: Nikzad Amir H. , Lysaker Paul H. , Minor Kyle S. , Leonhardt Bethany , Liberman Mark Y. , Vohs Jenifer , Wiesepape Courtney N. , Tang Sunny X. 
Published: November 2024

ABSTRACTAimMetacognitive Reflection and Insight Therapy (MERIT) is a form of person‐centred psychotherapy that promotes recovery‐oriented outcomes by targeting metacognitive capacity. Previous research has shown the feasibility and clinical benefits of MERIT. However, it is not clear whether and how the specific processes targeted by MERIT (e.g., improved sense of agency, self‐reflectivity, awareness of others, etc.) are manifested in the patient‐therapist communications. In this study, we used natural language processing (NLP) to explore objective linguistic markers of change during MERIT for early psychosis.MethodsFive patients underwent 24 sessions each of MERIT, which were recorded and transcribed verbatim. The transcripts underwent NLP to determine the patterns of pronoun use and the frequency of semantic categories related to temporality and mental processing. Mixed linear regressions were used to examine how NLP features evolve over the course of psychotherapeutic sessions.ResultsAnalyses detected shifts in specific language signals over time including (1) changes in patterns of pronoun usage with more active and central first‐person plural pronoun (We); (2) transition in temporal focus of speech from past‐focus towards present‐ and future‐focus and (3) increased words representing perceptual and cognitive processes.ConclusionOur findings suggest NLP can objectively quantify meaningful signals consistent with expected subjective changes in MERIT and potentially other psychotherapeutic interventions.
Sex and estradiol effects in the rodent dorsal striatum
Authors: Lewitus Valerie J. , Kim Jaekyoon , Blackwell Kim T. 
Published: November 2024

Abstract17β‐Estradiol (E2) is a sex hormone that acts on many brain regions to produce changes in neuronal activity and learning. A key brain region sensitive to E2 is the dorsal striatum (also called caudate‐putamen), which controls motor behaviour, goal‐directed learning and habit learning. In adult rodents, oestrogen receptors (ERs) in the dorsal striatum are localized to the plasma membrane and include ERα, ERβ and G protein‐coupled ER (GPER). E2, either naturally produced or exogenously applied, may influence neuronal excitability, basal synaptic transmission and long‐term synaptic potentiation. These effects may be due to direct action on signalling pathways or may be due to changes in dopamine availability. In particular, estradiol influences dopamine release, dopamine receptor expression and dopamine transporter expression. We review the cellular effects that E2 has in the dorsal striatum, distinguishing between exogenously applied E2 and the oestrous cycle, as well as its influence on dorsal striatal‐dependent motor and learning behaviour.
Addition of Fe‐humic acids to overcome analytical issues in measurements of isotopically exchangeable P in soil
Authors: Degryse Fien , Tucker William , McLaughlin Michael J. 
Published: November 2024

AbstractIsotopic dilution has been widely used to measure isotopically exchangeable phosphorus (P) in soil (E value), as a measure of potentially plant‐available P. However, in soils with low E values and/or strong P sorption, measurement of E values can be challenging due to very low solution concentrations and the interference of colloidal non‐exchangeable species, thus confounding the measurements in the soils of most interest. The addition of a complexing compound could increase solution concentrations and reduce these analytical issues, as has been found in the case of metals. Therefore, we investigated the addition of Fe‐humic acid (Fe‐HA) as a P‐complexing compound to the soil suspension prior to isotopic exchange. This results in the formation of P‐Fe‐HA complexes, thus increasing P solution concentrations by solubilizing P from the labile pool and reducing errors caused by suspended colloids. We used this method to measure E values in five soils with low P status, without or with the addition of carrier P. The addition of Fe‐HA (at 50 or 200 mg Fe‐HA/L to the equilibration solution) substantially decreased the measured E value without carrier P addition in four of the five soils, while there was no or little effect when carrier P was added. The higher Fe‐HA rate increased solution concentrations of stable and radioactive P more than the lower rate, but there was no significant difference in measured E values between the two Fe‐HA rates. The method was also applied to 15 subsoils with low P status. Overall, our results indicated that the addition of Fe‐HA provides an easy and robust way to avoid analytical issues in the determination of E values in soils with low concentrations of P in solution.
Measurement Must Be Qualitative, then Quantitative, then Qualitative Again
Authors: Ho Andrew D. 
Published: November 2024

AbstractEducational measurement is a social science that requires both qualitative and quantitative competencies. Qualitative competencies in educational measurement include developing and applying theories of learning, designing instruments, and identifying the social, cultural, historical, and political contexts of measurement. Quantitative competencies include statistical inference, computational fluency, and psychometric modeling. I review 12 commentaries authored by past presidents of the National Council on Measurement in Education (NCME) published in a special issue prompting them to reflect on the past, present, and future of educational measurement. I explain how a perspective on both qualitative and quantitative competencies yields common themes across the commentaries. These include the appeal and challenge of personalization, the necessity of contextualization, and the value of communication and collaboration. I conclude that elevation of both qualitative and quantitative competencies underlying educational measurement provides a clearer sense of how NCME can advance its mission, “to advance theory and applications of educational measurement to benefit society.”
Spatiotemporal neurodegeneration of the substantia nigra and its connecting cortex and subcortex in Parkinson's disease
Authors: Wen Jiaqi , Duanmu Xiaojie , Tan Sijia , Wu Chenqing , Peng Xiting , Qin Jianmei , Guo Tao , Wang Shuyue , Wu Haoting , Zhou Cheng , Hong Hui , Yuan Weijin , Zheng Qianshi , Wu Jingjing , Chen Jingwen , Fang Yuelin , Zhu Bingting , Yan Yaping , Tian Jun , Zhang Baorong , Zhang Minming , Guan Xiaojun , Xu Xiaojun 
Published: November 2024

AbstractBackground and purposeNeurodegeneration is uneven in Parkinson's disease (PD). This study aimed to investigate spatiotemporal neurodegeneration in functional subregions of the substantia nigra (SN) and their connected cortex and subcortex in people with PD.MethodsA total of 120 patients with early‐stage PD, 45 patients with advanced PD, and 120 healthy controls (HCs) were enrolled. The SN, cortex, and subcortex were divided into sensorimotor, associative, and limbic regions, respectively. Iron deposition in the SN was assessed by quantitative susceptibility mapping (QSM). Cortex and subcortex volumes were calculated based on T1‐weighted imaging. Region of interest (ROI) analysis and voxel‐based analysis (VBA) were performed to explore spatiotemporal neurodegeneration in patients with PD. p values were corrected for false discovery rate.ResultsIn the ROI analysis, the QSM values for the limbic (p = 0.018) and sensorimotor SN subregions (p = 0.018) were higher in PD patients than in HCs, but were not higher in the associative SN subregion (p = 0.295). In VBA, all SN functional subregions had clusters with higher QSM values in PD patients than in HCs (p < 0.001). The limbic SN subregion was the only one in which iron deposition increased from early‐stage to advanced PD (p = 0.023). The QSM values of VBA_limbic, sensorimotor, and associative SN had subregion‐specific correlations with disease severity (p = 0.001 for the limbic and sensorimotor subregions, p = 0.003 for the associative subregion), motor symptoms (p = 0.057 for the limbic and sensorimotor subregion), and depression scores (p = 0.036 for the limbic subregion).ConclusionIron deposition in SN functional subregions and atrophy of cortical and subcortical structures connected with the SN showed spatiotemporal selectivity. These findings reveal the potential pathogenesis of clinical heterogeneity in PD.
Plasma neuropeptide Y levels and adverse clinical outcomes after acute ischaemic stroke
Authors: Dong Wenjing , Lu Yaling , Long Jiayi , Peng Yanbo , Ju Zhong , Xu Tan , Zhang Yonghong , Zhai Guojie , Zhong Chongke 
Published: November 2024

AbstractBackground and purposeNeuropeptide Y (NPY) has been reported to be involved in the pathophysiology of several cardiovascular disease processes and might contribute to the incidence of stroke, but the prognostic utility of circulating NPY after acute ischaemic stroke is unclear. This study aimed to prospectively examine the association between plasma NPY levels and adverse clinical outcomes after acute ischaemic stroke.MethodsPlasma NPY levels were measured in 3250 patients (2066 men and 1184 women) from the China Antihypertensive Trial in Acute Ischaemic Stroke. The primary outcome was the combination of death and major disability (modified Rankin Scale score ≥3) at 12 months after stroke onset, and secondary outcomes included major disability, death and cardiovascular events.ResultsDuring the 12‐month follow‐up, 702 participants (21.6%) experienced major disability or died. After multivariable adjustment, odds ratio (95% confidence interval) for the highest quartile of NPY was 1.56 (1.19–2.04) for the primary outcome, compared to the lowest quartile. Each standard deviation (0.27 ng/mL) higher log‐transformed NPY was associated with an odds ratio (95% confidence interval) of 1.18 (1.07–1.30) for the primary outcome, 1.28 (1.15–1.42) for major disability. The addition of NPY to a conventional risk factors model improved risk prediction of the composite outcome of death and major disability (category‐free net reclassification index 8.82%, p = 0.040; integrated discrimination improvement 0.38%, p = 0.011).ConclusionsElevated plasma NPY levels in the acute phase of ischaemic stroke were associated with increased risk of poor clinical outcomes after ischaemic stroke, suggesting that plasma NPY may be a potential prognostic biomarker for ischaemic stroke.
Focal negative motor seizures: Multimodal evaluation
Authors: Di Giacomo Roberta , Colombo Rachele , Canafoglia Laura , Duran Dunja , Pastori Chiara , Stabile Andrea , Battaglia Giulia , Didato Giuseppe , Cuccarini Valeria , Deleo Francesco , Dominese Ambra , de Curtis Marco , Rossi Sebastiano Davide 
Published: November 2024

AbstractThis case report shows the importance of multimodal evaluation to formulate a proper diagnosis of negative motor seizures (NMSs). Only few reports in literature document NMSs with video‐electroencephalographic (EEG) and electromyographic coregistration. A multimodal evaluation is crucial to exclude common mimics and propose correct therapy. We describe a case of a 62‐year‐old man with drug‐resistant focal epilepsy and NMSs, evaluated with video‐EEG recording with polygraphy, magnetoencephalography (MEG), and brain magnetic resonance imaging (MRI). Video‐EEG monitoring showed 182 focal NMSs, with preserved awareness and comprehension. The patient reported complex paresthesia of the left hand followed by left facial grimace, left arm flaccid paralysis, and bradycardia. EEG showed ictal discharges in the right frontocentral region associated with sudden electromyographical silence in left limb muscles consistent with loss of tonic contraction from distal to proximal muscles of the arm. MEG localized the epileptic zone in the right opercular region, consistent with MRI evidence of type II cortical dysplasia in the right inferior frontal gyrus. Multimodal evaluation is essential to document the temporal relationship between ictal discharges, clinical onset of limb paresis, and electrophysiologic evidence of loss of tonic muscular contraction. It allows definition of the specific cortical area involved in NMSs, offering new insight into physiological brain functioning.
Effect of Surface Finish and Temperature on Low Cycle Fatigue Behavior of GRCop‐42
Authors: Demeneghi Gabriel , Gradl Paul , Diaz Agustin , Hazeli Kavan 
Published: November 2024

ABSTRACTThis study investigates the impact of various surface finishes on the low cycle fatigue (LCF) properties of laser powder bed fusion GRCop‐42. The evaluated surfaces include as‐built, machined, and chemically polished finishes (1.0% and 2.0% ranges). LCF life of polished GRCop‐42 was assessed at cryogenic (−195°C), ambient, and elevated temperatures (200°C, 400°C, 600°C, and 800°C) across three strain ranges. Results indicate that surface finish has minimal impact on LCF life. Stress across different strain levels showed minimal effect of surface finish on cyclic hardening/softening. Cryogenic temperatures led to cyclic hardening followed by stabilization, while ambient and 200°C temperatures showed initial hardening followed by softening. At 400°C and above, specimens displayed continuous cyclic softening. Fractography showed that surface finish impacts plastic deformation: as‐printed and polished surfaces had brittle fractures, while machined specimens were ductile. Specimens at cryogenic and ambient temperatures exhibited brittle fractures, whereas those at elevated temperatures showed plastic deformation and microcracks.
Fine‐Grain Predictions Are Key to Accurately Represent Continental‐Scale Biodiversity Patterns
Authors: Cohen Jeremy M. , Jetz Walter 
Published: November 2024

ABSTRACTAimAs global change accelerates, accurate predictions of species distributions and biodiversity patterns are critical to limit biodiversity loss. Numerous studies have found that coarse‐grain species distribution models (SDMs) perform poorly relative to fine‐grain models because they mismatch environmental information with observations. However, it remains unclear how grain‐size biases vary in intensity across space and time, possibly generating inaccurate predictions for specific regions, seasons or species. For example, coarse‐grain biases may intensify in patchy, discontinuous landscapes. Such biases may accumulate to produce highly misleading estimates of continental and seasonal biodiversity patterns.LocationUnited States and Canada.Time Period2004–2021.Major Taxa StudiedBirds (Aves).MethodsWe fit presence‐absence SDMs characterising the summer and winter distributions of 572 bird species native to the US and Canada across five spatial grains from 1 to 50 km, using observations from the eBird citizen science initiative. We combined these predictions to generate seasonal biodiversity estimates across the US and Canada, which we validated using observations from 322 independent sites.ResultsWe find that in both seasons, 1 km models more accurately predicted species presence, absence and richness at local sites. Coarse‐grain models (even at 3 km) consistently under‐predicted range area, potentially missing important habitat. This bias intensified during summer (83%–86% of species) when many birds have smaller ‘operational scales’ via localised home ranges while breeding. Biases were greatest in desert regions with patchier habitat and for range‐restricted and habitat‐specialist species. Predictions based on coarse‐grain models overpredicted avian diversity in the west and underpredicted it in the great plains, prairie pothole region and boreal zones.Main ConclusionsWe demonstrate that coarse‐grain models can bias seasonal and continental estimates of biodiversity patterns across space and time and that grain‐related biases intensify during summer and in patchier landscapes, especially for range‐restricted and habitat specialist species at risk of population declines.
Looking From the Margins and the Making of Feminist Urban Worlds
Authors: Parikh Aparna 
Published: November 2024

ABSTRACTThe field of feminist urban geography has shed light on the workings of power and its spatial manifestation at multiple scales. Weaving across this scholarship, I show that it is motivated by concerns about systemic hierarchies, emphasizes looking from the margins, and highlights alternative, emancipatory possibilities. First, these works show how patriarchal logics underpin institutional spaces and shape social norms that govern urban life in violent ways. Second, feminist scholarship has shown how the everyday lives of those at the margins can challenge and subvert a dominant making of boundaries between the public and private, or local and global. Third, they articulate how strategies to attain urban belonging, structured around commoning, care, and a call for freedom, can offer alternatives for just futures. Through a grounded understanding of everyday practices, this scholarship shows the significance of temporality in world‐making and complicates the notion of the urban as a site of aspiration. Moving forward, the field can be more attentive to how global urban margins hold promise in decentering power‐knowledge networks and showcase the place of the urban within center‐periphery relations. With this tool kit, feminist urban geography can provide provisional, conjectural possibilities to conceptualize more meaningful worlds.