bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Template Thematic Analysis of Self‐Concept and Self‐Compassion in People Living With Endometriosis: Analysis of Qualitative Survey Responses
Authors: Mazalin Kristi , Evans Subhadra , Van Niekerk Leesa 
Published: December 2024

ABSTRACTAimsTo explore the influence of endometriosis on an individual's self‐concept and the potential applicability of self‐compassion in addressing alterations to self‐concept.DesignQualitative deductive template analysis study.MethodsWritten reflections completed by women (n = 157) with a self‐reported diagnosis of endometriosis were reviewed using a deductive template approach to gain an understanding of how people living with endometriosis view themselves in the face of the diagnosis.ResultsUtilising Neff's (2003) definition of self‐compassion, a series of themes emerged, with a higher number of reflections noted for each of the negative components of self‐compassion (self‐judgement, isolation, overidentification). Themes associated with negative changes to self‐concept centred around reflections of inadequacy, self‐blame, loneliness, withdrawal and avoidance, feeling misunderstood and judged by others, feeling like a burden and emotional suppression and numbing.ConclusionsEndometriosis influences three core domains of self‐concept for the person (personal, social and physical). These findings indicate that the components of self‐compassion therapy may be of relevance for healthcare providers in addressing the alterations to self‐concept experience by individuals living with endometriosis.Implications for Patient CareThis study supports the need for access to timely diagnosis and interdisciplinary care to buffer against the negative consequences for self‐concept. Nurses and allied healthcare professionals can use these findings to provide compassion‐focused care, with an emphasis on self‐kindness, common humanity and mindfulness for individuals with endometriosis.ImpactThis lived experience research highlights the influence of endometriosis on the personal, social and physical components of self‐concept, indicating a critical need to address self‐concept as part of endometriosis‐related treatment. Alterations to self‐concept may emphasise negative perpetuating cognitions and reinforce isolation, suppression of personal needs and self‐silencing.Patient or Public ContributionNo patient or public contribution.
Changes in Distribution Ranges of Abies Species Dominating in the Forests of Northeast Asia Since the Last Glacial Maximum
Authors: Petrenko Tatyana , Dzizyurova Violetta , Altman Jan , Doležal Jiří , Kislov Dmitriy , Korznikov Kirill 
Published: November 2024

ABSTRACTAimClimate variations within the stadial–interstadial cycles drive shifts in the distribution of forest dominants. This study examines how climate dynamic alters the distribution ranges of two boreal and one cold‐temperate Abies species dominating in Northeast Asia.LocationNortheast Asia: China, Japan, Korea and Russia.TaxonAbies nephrolepis, A. sachalinensis (sect. Balsamea) and A. holophylla (sect. Pseudopicea).MethodsWe developed climate envelope species distribution models (SDMs) using warmth and coldness indices, the continentality index, and proxies of rain and snow precipitation indices. We interpolated SDMs on reconstructed climates for the Last Glacial Maximum (LGM) and the Holocene Climatic Optimum (HCO) and to predicted climates for 2070 under global warming scenarios RCP2.6 and RCP8.5.ResultsDuring the LGM, the climatic optimum for all species covered extensive areas on the shelves of the Japanese and Yellow Seas, facilitated by the global sea level drop. The interglacial climatic optimum supports the expansion of A. nephrolepis and A. sachalinensis compared to the LGM, whereas the range of A. holophylla climatic niche range experiences a reduction.Main ConclusionsOur findings highlight the significant impact of climatic oscillations on the spatial distribution and ecological dynamics of Abies species in Northeast Asia. The contrasting responses of boreal and temperate fir species to glacial and interglacial periods underscore the complex interplay between climate change and the distribution of forest dominants. Projections under future warming scenarios suggest that Abies species will face further range shifts, emphasising the need for adaptive forest management and conservation strategies, especially in the southern part of their distribution.
Hepatocyte‐Specific HuR Protects Against Acetaminophen‐Induced Liver Injury in Mice
Authors: Lu Linlin , Chen Jicui , Jiang Hui , Li Ni , Li Xiaojie , Liu Yinghao , Zong Chen 
Published: November 2024

ABSTRACTAcetaminophen (APAP) overdose is a major cause of drug‐induced liver injury (DILI) in many countries. Hepatocyte proliferation, autophagy and antioxidant capacity are crucial to the prognosis of APAP‐induced liver injury, but the underlying mechanisms are not fully understood. Here, we found that human antigen R (HuR) protein expression was markedly increased in the model of APAP‐induced liver injury, and conditional hepatocyte‐specific HuR knockout aggravated APAP‐induced liver injury in mice. Further investigation of the underlying mechanisms of HuR's protective effects showed that conditional hepatocyte‐specific HuR knockout reduced the protein expression of cyclin A1, cyclin B1, cyclin D1, CDK2, ATG3, ATG5, ATG7 and NRF2 in mice, reducing hepatocyte proliferation, autophagy and antioxidant capacity. Mechanistically, HuR could physically associate with the 3′‐untranslated regions (UTRs) of cyclin A1, cyclin B1, cyclin D1, Cdk2, Atg3, Atg5, Atg7 and Nrf2 mRNAs, thereby regulating their translation. These findings suggest that HuR attenuates APAP‐induced liver injury by regulating hepatocyte proliferation, autophagy and antioxidant capacity.
Katarium polorum n. sp., n. g., a novel thecofilosean amoeba (Cercozoa, Rhizaria) from the polar oceans
Authors: Solbach Marcel Dominik , Bonkowski Michael , Dumack Kenneth 
Published: November 2024

AbstractThecate amoebae play important roles in terrestrial and aquatic ecosystems. This study introduces a novel thecofilosean amoeba from Arctic and Antarctic sea sediments. Phylogenetic analysis based on the 18S rDNA sequence places it in the family Chlamydophryidae (order Tectofilosida, class Thecofilosea). However, the novel organism exhibits a significant genetic divergence and distinct morphology from its closest relatives, prompting us to erect the novel genus Katarium with its type species Katarium polorum. K. polorum is a consumer of diatoms and prokaryotes, indicating an important role in nutrient cycling in the polar marine food webs.
TCR Repertoire Analysis During Therapeutic Interventions in Liver Diseases Using Next‐Generation Sequencing
Authors: Nakakuki Natsuko , Maekawa Shinya , Takano Shinichi , Osawa Leona , Komiyama Yasuyuki , Takada Hitomi , Muraoka Masaru , Suzuki Yuichiro , Sato Mitsuaki , Enomoto Nobuyuki 
Published: December 2024

ABSTRACTBackground and AimThe T cell receptor (TCR) can recognize a vast number of antigens and is closely associated with the pathogenesis of various diseases including autoimmune diseases and malignancies. However, the clinical significance of the TCR repertoire and its post‐treatment changes remain unclear in liver diseases.MethodsWe performed next‐generation sequencing (NGS)‐based TCR analysis using DNA obtained from peripheral blood mononuclear cells (PBMCs) of healthy donors (HD, n = 5), primary biliary cholangitis (PBC, n = 5), autoimmune hepatitis (AIH, n = 5), and hepatocellular carcinoma (HCC, n = 5) and evaluated the changes after treatment.ResultsBaseline TCR repertoire analysis demonstrated that TCR clonotype usage is restricted and diversity is low in all three disease groups (PBC, AIH, and HCC), particularly in PBC and AIH compared to HD (p < 0.05). Following treatment, clonotype usage and diversity did not change significantly, except in AIH, where diversity decreased further (p < 0.05 for clone Shannon diversity and clone evenness). Disease‐specific usage of TCR beta genes and specific changes after therapy were observed in all groups. Analysis of clonotypes shared with other individuals (public clonotypes) revealed that nine public clonotypes in PBC, eight in AIH, and eight in HCC disappeared after treatment. Motif analysis identified one characteristic motif (NQPQH) in PBC.ConclusionsThe diversity of the TCR repertoire, TCR beta chain usage, clonotypes, and motifs and their post‐treatment changes are disease‐specific in each liver disease, indicating that further TCR repertoire studies are needed to accelerate the understanding of liver disease pathogenesis from an immunological perspective.
RBB1 negatively regulates rice disease resistance by modulating protein glycosylation
Authors: Zhang Bin , Guo Mingliang , Liu Xiangpei , Zhang Bintao , Cui Yan , Cao Xinglan , Zhang Zhipeng , Shi Chuanlin , Wei Hua , He Huiying , Zhang Hong , Zhu Yiwang , Wang Xianmeng , Lv Yang , Yu Xiaoman , Chen Dandan , Yuan Qiaoling , Teng Sheng , Sun Tongjun , Qian Qian , Shang Lianguang 
Published: December 2024

ABSTRACTGlycosylation, a prevalent post‐translational modification in eukaryotic secreted and membrane‐associated proteins, plays a pivotal role in diverse physiological and pathological processes. Although UDP‐N‐acetylglucosamine (UDP‐GlcNAc) is essential for this modification, the specific glycosylation mechanisms during plant leaf senescence and defense responses remain poorly understood. In our research, we identified a novel rice mutant named rbb1 (resistance to blast and bacterial blight1), exhibiting broad‐spectrum disease resistance. This mutant phenotype results from a loss‐of‐function mutation in the gene encoding glucosamine‐6‐phosphate acetyltransferase, an important enzyme in D‐glucosamine 6‐phosphate acetylation. The rbb1 mutant demonstrates enhanced defense responses, evident in increased resistance to rice blast and bacterial blight, along with the upregulation of defense‐response genes. Various biochemical markers indicate an activated defense mechanism in the rbb1 mutant, such as elevated levels of reactive oxygen species and malondialdehyde, reduced enzyme activity and UDP‐GlcNAc content, and decreased expression of N‐glycan and O‐glycan modifying proteins. Moreover, proteome analysis of N‐glycosylation modifications reveals alterations in the N‐glycosylation of several disease‐resistance‐related proteins, with a significant reduction in Prx4 and Prx13 in rbb1‐1. Additionally, the knockout of Prx4 or Prx13 also enhances resistance to Xanthomonas oryzae pv. oryzae (Xoo) and Magnaporthe oryzae (M. oryzae). This study uncovers a novel mechanism of defense response in rice, suggesting potential targets for the development of disease‐resistant varieties.
Situating legal consciousness and legal compliance: how Dutch welfare clients think and act in relation to the law
Authors: HERTOGH MARC 
Published: November 2024

AbstractHow does legal consciousness matter for compliance? Thus far, this issue has been addressed by two bodies of literature that each focus on one side of the equation but do not speak to each other. Legal consciousness studies analyse how people understand the law but focus less on their compliance with the law. Conversely, most legitimacy studies focus on people's compliance with the law but do not analyse their perceptions of the law. This article draws on the findings from an online survey among Dutch welfare clients to empirically bridge both literatures. I look not only at clients’ own (first‐order) legal consciousness, but also at their second‐order legal consciousness: clients’ assessment of welfare officials’ beliefs about the law. I argue that the connection between legal consciousness and legal compliance is not a unitary phenomenon, but must be situated in relation to particular laws and social hierarchies.
Two new species of Late Devonian seed Cosmosperma from Zhejiang and Anhui, South China
Authors: Liu Le , Wang De‐Ming , Zhou Yi , Qin Min , Xu Peng , Mu Jia‐Jun 
Published: December 2024

AbstractThe earliest ovules or seeds widely reported from the Late Devonian (Famennian) are crucial for understanding the evolution of seed plants. Cosmosperma, the first Devonian seed documented in China and East Asia, is characterized by cupules with multiple segments enclosing a single ovule and covered by prickles. Two new Cosmosperma species, Cosmosperma dicrana sp. nov. and Cosmosperma lepta sp. nov., are now identified from the Upper Devonian (Wutong Formation) of Zhejiang and Anhui provinces, China, respectively. C. dicrana exhibits dichotomized fertile branches terminating in pairs of cupulate ovules, with centrifugally extending cupule segments at their distal portions. C. lepta displays slender cupulate ovules on pinnate fertile branches. Both species possess prickles on their cupules. A comparison with coeval seed plant taxa reveals differences in fertile branch types and suggests different evolutionary levels. The potentially weak dispersal ability of Cosmosperma is suggested by the absence of specialized structures for wind or water transport. Prickles on Cosmosperma cupules do not suggest adaptations for epizoochory but facilitate entanglement and friction. The adaptations for short‐distance dispersal can be advantageous in a disturbed and heterogeneous environment. The presence of Late Devonian seed plant taxa with dispersal‐adapted traits hints at habitat divergence, with some possibly inhabiting uplands or areas away from the coast. The prickles may also be an adaptation for maintaining stability in small‐ to medium‐sized plants of the Late Devonian coastal communities.
Mexico under the universal human rights system: The case of the committee on the protection of the rights of all migrant workers and members of their families
Authors: Iza Daniela González 
Published: December 2024

AbstractThe relationship between Mexico and human rights treaty bodies has been paradigmatic due to the adoption of a foreign policy based on an openness to international scrutiny that is not reflected in the internal situation of human rights. An example of this contradiction is the case of the rights of migrants in Mexico. The objective of this article is to analyze the effects of mechanisms of the United Nations System of Human Rights, specifically the Committee on the Protection of the Rights of All Migrant Workers and Members of Their Families in Mexico, to determine the scope of the impact of civil society on the guarantee of human rights of migrants despite the lack of international consensus regarding the International Convention on the Protection of the Rights of All Migrant Workers and Members of Their Families.
Applying benefits theory to rationalize property tax exemptions for nonprofit organizations
Authors: Calabrese Thad D. 
Published: December 2024

AbstractCurrent public policy grants nonprofits property tax exemptions simply because of their status, often assuming they are “charitable,” “educational,” or “health‐related.” This research note argues exemptions should be based on the public or private benefits provided, and not be given to all nonprofits. According to benefits theory, public funds should not finance private benefits; beneficiaries should cover those costs. Property tax exemptions should be reserved for organizations offering public goods or services. In New York City, these exemptions are costly, yet only a small portion supports nonprofits that produce public goods or services.
Supporting Transgender, Nonbinary, and Gender Diverse Youth During Solid Organ Transplantation
Authors: Alexander Kelsi , Goodall Joanne , Allen Brittany J. 
Published: December 2024

ABSTRACTAs gender diversity becomes more understood and accepted in mainstream culture, medical systems and health care providers must learn to provide comprehensive and affirming care to gender diverse individuals. As the number of gender diverse pediatric patients continues to grow, these patients will be cared for by pediatric solid‐organ transplant programs. This review summarizes the basic principles of gender‐affirming care and describes how transplant teams can provide equitable and affirming care to young gender diverse patients undergoing solid organ transplant (SOT). In addition, this review uses kidney transplant as a framework to explore gender‐affirming hormone therapy and gender‐affirming surgery in the setting of transplant, laboratory value interpretation in gender diverse individuals, and the importance of an individualized approach in care of the gender diverse transplant recipient.
The Isodon serra genome sheds light on tanshinone biosynthesis and reveals the recursive karyotype evolutionary histories within Lamiales
Authors: Hou Liqiang , Niu Zhimin , Zheng Zeyu , Zhang Jin , Luo Changhong , Wang Xiaojuan , Yang Yongzhi , Li Ying , Chen Qiao 
Published: November 2024

SUMMARYLamiales is one of the largest orders of angiosperms with a complex evolutionary history and plays a significant role in human life. However, the polyploidization and chromosome evolution histories within this group remain in mystery. Among Lamiales, Isodon serra (Maxim.) Kudô shines for its abundance of diterpenes, notably tanshinones, long used in East Asia to combat toxicity and inflammation. Yet, the genes driving its biosynthesis and the factors governing its regulation linger in obscurity. Here, we present the telomere‐to‐telomere genome assembly of I. serra and, through gene‐to‐metabolite network analyses, pinpoint the pivotal tanshinone biosynthesis genes and their co‐expressed transcription factors. Particularly, through luciferase (LUC) assays, we speculate that IsMYB‐13 and IsbHLH‐8 may upregulate IsCYP76AH101, which is the key step in the biosynthesis of the tanshinone precursor. Among Lamiales, Oleaceae, Gesneriaceae and Plantaginaceae successively sister to a clade of seven Lamiales families, all sharing a recent whole‐genome duplication (designated as α event). By reconstructing the ancestral Lamiales karyotypes (ALK) and post‐α event (ALKα), we trace chromosomal evolution trajectories across Lamiales species. Notably, one chromosomal fusion is detected from ALK to ALKα, and three shared chromosomal fusion events are detected sequentially from ALKα to I. serra, which fully supports the phylogeny constructed using single‐copy genes. This comprehensive study illuminates the genome evolution and chromosomal dynamics of Lamiales, further enhancing our understanding of the biosynthetic mechanisms underlying the medicinal properties of I. serra.
Effects of theory‐guided unsupervised exercise on depression, sleep quality, and sense of control in pregnant women: A randomized controlled trial
Authors: Weng Min‐Hsueh , Chou Hung‐Chieh , Chang Yue‐Cune , Liaw Jen‐Jiuan 
Published: November 2024

AbstractBackgroundUnsupervised exercise is beneficial for pregnant women, and ongoing exercise may affect the course of pregnancy. Therefore, promoting continued exercise among women is critical.AimsTo implement a home‐based exercise program, guided by the COM‐B model theory, and assess its effects on depression, sleep quality, and sense of control among pregnant women.MethodsPregnant women (N = 100) were selected and randomly assigned in a 1:1 ratio to either the intervention or the control group. Both groups received exercise instruction. The intervention group received an additional intervention based on the COM‐B model theory. Depression and sleep quality were evaluated at 28 and 35 weeks of gestation, while women's sense of control was assessed at 35 weeks of gestation.ResultsIn total, 91 participants completed the study, with 100 included in the intention‐to‐treat analysis. The intervention group showed improvement in depression at 28 and 35 weeks of gestation and in sleep quality at 35 weeks. Although there was no significant difference in the sense of control between the groups, the intervention group demonstrated better emotional control.Linking Evidence to ActionA theory‐guided exercise intervention shows benefits in improving third‐trimester depression, sleep quality, and emotional control. Therefore, exercise programs during pregnancy should consider to encompass capacities, opportunities, and motivations to encourage exercise behavior.
Tensor categories of weight modules of sl̂2$\widehat{\mathfrak {sl}}_2$ at admissible level
Authors: Creutzig Thomas 
Published: November 2024

AbstractThe category of weight modules of the simple affine vertex algebra of at an admissible level is neither finite nor semisimple and modules are usually not lower‐bounded and have infinite‐dimensional conformal weight subspaces. However, this vertex algebra enjoys a duality with , the simple principal ‐algebra of at level (the super conformal algebra) where the levels are related via . Every weight module of is lower‐bounded and has finite‐dimensional conformal weight spaces. The main technical result is that every weight module of is ‐cofinite. The existence of a vertex tensor category follows and the theory of vertex superalgebra extensions implies the existence of vertex tensor category structure on for any admissible level . As applications, the fusion rules of ordinary modules with any weight module are computed, and it is shown that is a ribbon category if and only if is, in particular, it follows that for admissible levels and and , the category is a ribbon category.
Impaired glucose tolerance and insulin resistance in a prenatally‐androgenized rat model of polycystic ovary syndrome in later life
Authors: Farhadi‐Azar Mahbanoo , Noroozzadeh Mahsa , Mousavi Maryam , Saei Ghare Naz Marzieh , Ramezani Tehrani Fahimeh 
Published: November 2024

AbstractPolycystic ovary syndrome (PCOS), one of the most common endocrine disorders in reproductive‐aged women, is associated with metabolic disturbances. The present study aimed to examine changes in body weight (BW) and glucose and insulin tolerance in a prenatally‐androgenized (PNA) rat model of PCOS compared to control with increasing age. Pregnant rats in the experimental group were subcutaneously injected with 5 mg of free testosterone on the 20th day of pregnancy, while the control group received the solvent. Female offspring of both groups, PNA rats (rat model of PCOS) and control, were examined in terms of changes in BW, glucose and insulin tolerance at 3, 6, 12 and 20 months of age. BW at birth (6.53 ± 0.89 vs. 5.60 ± 1.18 g; P = 0.038), 15 (25 ± 1.15 vs. 22.36 ± 3.98 g; P = 0.019) and 30 (59.37 ± 10.19 vs.49.9 ± 9.39 g; P = 0.022) days of age was significantly increased in the rat model of PCOS compared to control, but no significant differences were observed in BW of the rat model of PCOS compared to control at 60 (P = 0.155) and 75 (P = 0.932) days or at 3 (P = 0.239), 6 (P = 0.782), 12 (P = 0.755) and 20 (P = 0.092) months of age. Rat model of PCOS showed impaired glucose tolerance (IGT) at 3 months of age (P = 0.020) and insulin resistance (IR) with increasing age (3–20 months of age) compared to control. Increased BW before puberty, IGT at 3 months of age and IR with increasing age were observed in our rat model of PCOS. This rat model may contribute to a better understanding of underlying mechanisms of changes in BW, IGT and IR in future studies.
Supplemental Material: Timing of and pressure-temperature constraints on deformation in the Toxaway dome, eastern Blue Ridge: Evidence for continuous deformation from the Neoacadian to the Alleghanian orogenies
Authors: Levine Jamie S.F. , al. et 
Published: December 2024

<p>Tables S1 and S2 include microprobe data for garnet, biotite, muscovite, and plagioclase used to determine the pressure-temperature conditions in Toxaway dome samples. Table S3 includes Cameca Ultrachron electron microprobe data for monazite dated in this study. We include dates and errors as well as compositional data from each sample. </p>