bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving students’ professional communicative competence in TEFL context
Authors: Khasanova Zarina 
Published: December 2024

Abstract

This study addresses the challenge of improving students’ professional communicative competence in Teaching English as a Foreign Language (TEFL) contexts, recognizing the growing importance of English in global professional environments. A mixed-methods approach was employed, involving 120 undergraduate students in a 12-week intensive course. The intervention included simulated workplace scenarios, authentic materials, project-based learning, technology integration, and guest lectures. Data were collected through pre- and post-tests, questionnaires, classroom observations, semi-structured interviews, and reflective journals. Quantitative findings revealed significant improvements across all language skills, with speaking showing the highest increase (28.5Questionnaire results indicated enhanced self-perceived competence in professional communication. Qualitative data from observations and interviews highlighted increased student participation, improved use of professional vocabulary, and greater confidence in professional communication scenarios. The integration of quantitative and qualitative findings demonstrates the effectiveness of the intervention in enhancing students’ professional communicative competence. The study underscores the value of a focused, practical approach to teaching professional communication in TEFL contexts, preparing students more effectively for the demands of English use in professional settings.
GESTÃO DO CONHECIMENTO APLICADO À AMBIENTES PROMOTORES DE INOVAÇÃO
Authors: Shirado Yuri , Molina Letícia Gorri 
Published: December 2024

Ambientes Promotores de Inovação surgem e formalizam-se por intermédio do Decreto 9.283/2018, como espaços oportunos para a concepção da inovação. Considerando-se a Sociedade do Conhecimento associada ao processo de transformação da informação, os referidos ambientes configuram-se como indutores da competitividade e de desenvolvimento socioeconômico. Assim, visa-se apresentar a relevância da aplicabilidade da Gestão do Conhecimento junto a Ambientes Promotores de Inovação, além de compreender a inter-relação das mesmas. Em linhas gerais, desenvolveu-se uma pesquisa exploratória e descritiva, com delineamento bibliográfico. Por fim conclui-se que a aplicação da Gestão do Conhecimento contribui estrategicamente para o desenvolvimento dos referidos ambientes
Efficacy of Various Heat-treated Retreatment File Systems on the Apical Deformity and Canal Centering Ability in a Single-rooted Teeth using Nano CT
Authors: S Swathi , Solete Pradeep , Jeevanandan Ganesh , Priscilla Antony S Delphine , Venkata Teja Kavalipurapu , Sanju Dona 
Published: December 2024

Aim
To analyze the efficacy of various heat-treated retreatment file systems on the apical deformity and canal centering ability in single-rooted teeth using nano CT.

Materials and Methods
A total of 45 single-rooted teeth were decoronated to 18mm and obturated. Three retreatment file systems were used, such as: Group 1- Solite RS3 Retreatment, Group 2- Solite RS3 Black Retreatment, and Group 3 - Solite RE Black Retreatment. All these procedures were carried out by a single operator. Nano-Computed tomography (CT) scans, pre- and post-operative, were obtained and superimposed for analysis. One-way ANOVA and post hoc tests were done to test the significance between the three groups.

Results
Based on the results, it was inferred that the Solite RE Black file system had better canal centering ratio and less apical deformity during the retreatment compared to Solite RS3 and Solite RS3 Black (p<0.05).

Conclusion
Solite RE Black file systems had superior centering ability in all apical thirds and less transportation in the middle and coronal thirds when compared to the other two retreatment file systems.
Morphometric Changes in a Sample of Various Age Groups of the Thai Population: A Panoramic Radiographic Study
Authors: Tantanapornkul Weeraya , Tohnak Sirilawan , Deepho Chutamas , Wamasing Peerapong , Sopapornamorn Praweena , Suwannakul Suttipalin 
Published: December 2024

Objective
The current investigation was conducted to examine the alterations in oral conditions and panoramic image parameters that occur with age.

Methods
The study sample consisted of 300 male participants and 300 female participants, ranging in age from 10 to 69 years. The age-related changes in intraoral circumstances and morphometric parameters, as observed in panoramic photographs, were explored. A two-way parametric analysis of variance was used to examine the effects of age group and sex. The frequencies and percentages were calculated and compared among groups using the chi-squared test for category variables. A p-value below 0.05 was considered to be statistically significant.

Results
The prevalence of intraoral conditions showed a positive correlation with advancing age. Males exhibited significantly higher crown, root, and tooth lengths in both the upper and lower canines. There was a significant difference between males and females in terms of the pulp area, the pulp-tooth ratio of the upper first molars, and the pulp area of the lower first molars (p < 0.05). The study found a substantial correlation between the radiomorphometric parameters and age, with similar trends observed in both males and females.

Conclusion
The findings of our research have the potential to contribute to the evaluation of an individual's age category and offer insights into the patterns of several observable factors on panoramic radiographs.
First Insight into the Mutational Landscape of BRAF and KRAS Genes in Lung Cancer Patients from Morocco
Authors: El Founini Younes , Guessous Fadila , Dehbi Hind , Karkouri Mehdi , Attaleb Mohammed , El Mzibri Mohammed , Boubia Souheil , Ridai Mohamed , Chaoui Imane 
Published: December 2024

Background:
Lung cancer (LC) is a lethal malignancy with a late diagnosis
and poor prognosis. During the last decade, the identification of oncogenic driver alterations
has noticeably changed the therapeutic landscape and contributed to the emergence
of the “oncogene addiction” concept and precision medicine in oncology. Among these
alterations, the spotlight has turned to driver mutations in the KRAS and BRAF genes,
which have garnered significant attention due to the emergence of targeted therapies and
the potential for personalized treatment strategies.

Objective:
Hence, the present study aimed to evaluate the mutational landscape of the
KRAS and BRAF genes in LC Moroccan patients along with their frequencies and their
correlation with clinicopathological features.

Methods:
A total of 60 fresh biopsies were collected from patients with primary LC and
were subjected to PCR-DNA sequencing of exon 2 of KRAS and exon 15 of BRAF genes
in order to detect the most common mutations known by their implication in response to
targeted therapies.

Results:
Sequencing analysis revealed that mutations in KRAS and BRAF genes represented
respectively 8.3% and 6.7% of cases; one patient had two KRAS mutations (G12A
and K5E), and none had simultaneous BRAF and KRAS mutations. The vast majority of
patients harboring KRAS mutations were men, formal smokers with adenocarcinomas,
and at advanced stage (stage III). BRAF mutations were mainly detected in men and nonsmokers
with adenocarcinoma. Statistical analyses showed no significant correlation between
KRAS and BRAF substitutions and clinico-pathological features (p>0.05).

Conclusion:
The presence of these mutations will be used as a valuable molecular biomarker
to select potential candidates eligible for effective personalized medicine using
available agents targeting these mutations. Much effort is needed to identify other druggable
mutations to generalize personalized LC therapy for better management of this devastating
disease.
Liposomal Drug Delivery System for the Management of Prostate Cancer: An Update
Authors: Kumar Amit , Lunawat Akshay Kumar , kumar Ashutosh , Islam Md. Moidul , Narang Raj Kumar , Raikwar Sarjana 
Published: December 2024

Abstract:
Prostate cancer is a significant health concern affecting a large population of males
worldwide. Liposomes, with their versatile properties and drug delivery capabilities, hold promise
as a targeted and efficient delivery system for prostate cancer treatment. Various studies have explored
different liposomal formulations loaded with anticancer agents to improve drug efficacy, reduce
side effects, and enhance targeted delivery to prostate cancer cells. Future research in this
area should focus on refining liposomal formulations to maximize drug encapsulation, stability,
and specific targeting of prostate cancer cells. Understanding the tumor microenvironment and utilizing
stimuli-responsive liposomes can further enhance drug release at the targeted site. Additionally,
investigating the biodistribution and pharmacokinetics of liposomal drug delivery systems in
vivo will provide valuable insights into their efficacy and potential for clinical translation. Overall,
liposome-based drug delivery systems have the potential to revolutionize prostate cancer treatment,
ultimately improving patient outcomes and quality of life. Further advancements and continued
research in this field will contribute to the development of effective and personalized therapeutic
strategies for prostate cancer patients.
Ionic Conductivity and Viscosity Behavior of PMMA-based Nano-dispersed Polymer Gel Electrolytes Containing Lithium Perchlorate
Authors: Lath Subodh Kant , Kumar Rajender , Kumar Rajiv , Sharma Shuchi , Pathak Dinesh , Arora Narinder , Sharma Viney , Kahol Manoj 
Published: December 2024

Abstract:
In this study, nano-dispersed polymer gel electrolytes containing
polymethylmethacrylate (PMMA), lithium perchlorate (LiClO4), diethyl carbonate
(DEC), dimethylacetamide (DMA), and nano-sized fumed silica (SiO2) have been
synthesized and characterized. The electrolytes showed high ionic conductivity for
electrolytes with higher dielectric constant solvents. The polymer enhanced the ionic
conductivity of liquid electrolytes having a lower dielectric constant solvent (DEC) at
all PMMA concentrations than the electrolytes containing a high dielectric constant
solvent (DMA). Further, with the addition of nano-sized fumed silica, the ionic conductivity
showed a small increase along with an increase in the mechanical stability
of the electrolytes. The viscosity behavior of the electrolytes was also discussed, and
it was correlated with the results of the ionic conductivity test. Nano-dispersed polymer
gel electrolytes exhibited high ionic conductivity (10-2 S/cm). Further, the conductivity
showed only a small change (by a factor, not by an order) over the 25-100°C
temperature range and did not vary with time, which is desirable for their use in practical
applications.
Combating Cholera in Syria: A Comprehensive Approach to Clean Water, Sanitation, and Vaccination
Authors: Komal  , Jindal Priya , Joshi Sachin , Singh Lovekesh , Singh Amandeep 
Published: December 2024

Introduction:
This study presents a comprehensive strategy for combating cholera in Syria,
with a focus on clean water initiatives, treatment, surveillance, and vaccination, and the critical
role of clean water in halting disease transmission.

Methods:
The review design has involved a thorough research and review of existing literature and
data on cholera outbreaks in Syria. It has also included an analysis of vaccination and treatment options,
as well as an exploration of cholera surveillance systems and clean water initiatives.

Results:
Key findings have indicated that prioritizing access to clean water through community water
management plans and water purification technologies is essential for cholera prevention. Case
studies, supported by epidemiological data up to September 2023, have underscored the importance
of clean water in stopping cholera spread.

Conclusion:
The study has highlighted the urgent need for a comprehensive strategy to protect millions
in Syria through enhanced water, sanitation, and vaccination measures. It has advocated for
improved cholera surveillance and response systems, along with continued efforts to ensure clean
water access for all.
Daya Dukung Lahan Permukiman Berbasis Kemampuan Lahan di Wilayah Peri-Urban (Studi Kasus: Kabupaten Bekasi, Kabupaten Tangerang dan Kabupaten Bogor)
Authors: Fadhilah Raina Arfa , Dimyati Muhammad , Indra Tito Latif , Gracia Enrico 
Published: December 2024

Lahan merupakan sumberdaya penting yang kebutuhannya terus meningkat. Namun, ketersediaannya tidak bertambah yang memicu alih fungsi lahan di perkotaan, dan berefek pada perluasan lahan permukimannya ke pinggiran kota, yang disebut peri-urbanisasi. Jabodetabekjur adalah wilayah metropolitan terpadat di Indonesia dengan Kota Jakarta sebagai kota inti dan peri-urban, khususnya Kabupaten Bekasi, Kabupaten Tangerang dan Kabupaten Bogor. Penelitian ini bertujuan mengevaluasi daya dukung lahan permukiman berbasis kemampuan lahan berdasarkan dinamika fisik, sosial dan ekonomi wilayah peri-urban Kota Jakarta sebagai salah satu upaya perencanaan, pemanfaatan dan pengawasan lahan berkelanjutan. Metode yang digunakan dalam penelitian ini adalah studi literatur dengan data-data yang dikumpulkan dari sumber terkait. Hasil menunjukkan bahwa kemampuan pengembangan lahan permukiman di Kabupaten Bekasi, Kabupaten Tangerang, dan Kabupaten Bogor masih cukup tinggi, tepatnya masing-masing sebesar 97%, 98% dan 45,96% dan memiliki status daya dukung permukiman surplus masing-masing sebesar 2,6, 2,7, dan 1,87. Lahan permukiman potensial yang dihasilkan membentuk pola menyebar menuju dataran rendah dan wilayah studi kasus memiliki wilayah yang sudah bersifat kekotaan.
Neuro-ophthalmologic manifestations of COVID-19: a review
Authors: Indra Tri Mahayana  , Stefani Melisa Karina  , Nyssa Alexandra Tedjonegoro  
Published: December 2024

Several mechanisms for the pathogenesis of COVID-19 have been proposed. These are direct viral toxicity, endothelial cell damage and thromboinflammation, dysregulated immune response, and renin-angiotensin-aldosterone system (RAAS) dysregulation. The ophthalmic manifestations of COVID-19 vary, affecting the anterior, posterior, and neuro-ophthalmic components. However, the relationship between COVID-19 and neuro-ophthalmologic presentations is limited. This literature review focuses on discussing these manifestations. A manual search was performed using the following keywords “neuro-ophthalmology”, “ocular”, “manifestations”, COVID-19, and coronavirus. The searches were conducted in PubMed and Google Scholar, where any study type and online publications were included. The most common ocular manifestation found in COVID-19 patients is conjunctival involvement. Some reported neuro-ophthalmic manifestations of COVID-19 are papillophlebitis, optic neuritis, cranial nerve palsies, Miller Fisher syndrome, Tolosa-Hunt syndrome, Adie’s tonic pupil, and internuclear ophthalmoplegia. A physician should examine the presence of diplopia, pain during eye movement, declining vision, or any other neurological symptoms. Therefore, it is essential to perform a comprehensive eye examination which includes visual acuity, pupillary response, ocular motility, ptosis, and optic disc examination. Additional tests such as neuroimaging or angiography might be performed to detect cerebral infarction or any other abnormalities when necessary. It is vital to be vigilant and consider COVID-19 as one of the possible causes of disease during this pandemic.
Pemberdayaan Kelompok Masyarakat Sub Urban Guna Meningkatkan Edukasi Dalam Teknik Pengelolaan Sampah di Padukuhan Dukuh, Sinduharjo, Ngaglik, Sleman DIY
Authors: Sudaryatno Sudaryatno , Prasetya Agus , Sulaiman Muhammad , Sartika Heni Wahyu , Santoso Dian Hudawan , Bato Marjan , Hidayatunnisa Nurul Fadhlya , Maliga Iga , Kisnanto Indro 
Published: December 2024

Padukuhan Dukuh merupakan salah satu wilayah yang sedang mengembangkan proses pengelolaan sampah organik dan anorganik berbasis budidaya maggot Black Soldier Fly (BSF). Hal ini merespon dari timbulan sampah organik dan anorganik yang semakin tinggi pada TPA Piyungan DIY. Tujuan dari program pengabdian ini adalah melakukan sosialisasi dan pembinaan serta pendampingan berkelanjutan terhadap kelompok masyarakat melalui kelompok sampah “Migunani” untuk mengolah sampah rumah tangga secara mandiri yang dapat dimanfaatkan berbagai kebutuhan. Dengan demikian, permasalahan sampah dapat dikurangi dan menambah nilai ekonomi warga masyarakat. Metode pelaksanaan kegiatan dibagi 6 tahap yaitu: 1) tahapan persiapan dan perizinan; 2) workshop dan edukasi masyarakat; 3) pelatihan dan pendampingan berkala; 4) studi banding di Omah Maggot Jogja; 5) pembagian alat pengelolaan sampah berupa karung komposter, tong komposter dan alat bor biopori; dan 6) tahapan monitoring dan evaluasi. Hasil dari seluruh rangkaian pengabdian berjalan dengan baik dan lancar. Hasil yang diharapkan dalam jangka panjang adalah kemandirian masyarakat dalam mengelola sampah organik dan anorganik sehingga sampah dari Padukuhan Dukuh tidak perlu dibawa ke TPA. Kesimpulan dalam program ini adalah kelompok masyarakat mendapatkan peningkatan pengetahuan dan mulai melakukan pengelolaan sampah baik bagi rumah maggot maupun secara mandiri di rumah masing-masing.
CONHEÇA E UTILIZE SOFTWARE EDUCATIVO
Authors: Spirandeli Rocha Ricael , Teixeira Nakamoto Paula 
Published: December 2024

Resenha

O livro “Conheça e utilize software educativo: avaliação e planejamento para a educação básica”, escrito por Ana Cristina Barbosa da Silva e Alex Sandro Gomes, traz uma proposta coesa para os leitores, no formato de um guia para profissionais da educação. Essa obra aproxima os educadores da familiarização didática digital para utilização de tecnologias digitais de informação e comunicação (TDIC) no contexto escolar.
Pet obesity causes and product differentiation opportunities in the pet food industry
Authors: Hobbs Lonnie , Shanoyan Aleksan , Bergtold Jason 
Published: December 2024

Abstract
Growth in pet obesity levels and demand for health and wellness focused pet food creates opportunities for pet food companies to capitalize on the rising profit potential through product differentiation. Lessons from the human food industry indicate that the weight management segment of the market tends to grow fast and is characterized by high product differentiation and premiumization. Despite the recent rise in pet health and obesity studies, literature translating findings to actionable management and marketing insights in the pet food context is significantly underdeveloped. This paper bridges the agribusiness management and pet food economics literature by generating insights for informing product innovation, design, and marketing strategies of pet food companies aimed at promoting healthy weight in pets. Econometric analysis of cross-sectional data from a survey of 1173 dog owners suggests that opportunities exist for potential pet food differentiation through physical changes, perceptual changes, and associated service changes in the pet food market related to handling pet obesity. Findings highlight the potential of low-calorie and breed-specific product formulation, pre-package product design, and consumer education through conventional and digital media. The management implications and actionable insights are discussed to inform product development and marketing strategies in the context of the fast-growing pet food market.
Metformin Treatment With or Without Mediterranean Diet for the Prevention of Age-Related Diseases in People With Metabolic Syndrome: The MeMeMe Randomized Trial
Authors: Pasanisi Patrizia , Oliverio Andreina , Baldassari Ivan , Bruno Eleonora , Venturelli Elisabetta , Bellegotti Manuela , Gargano Giuliana , Morelli Daniele , Bognanni Antonio , Rigoni Marta , Muti Paola , Berrino Franco 
Published: December 2024

OBJECTIVE
The Metformin and Dietary Restriction to Prevent Age-Related Morbid Events in People With Metabolic Syndrome (MeMeMe) trial tested whether 1,700 mg/day metformin (MET) with or without a Mediterranean diet (MedDiet) intervention could reduce the cumulative incidence of major noncommunicable diseases in people with metabolic syndrome.

RESEARCH DESIGN AND METHODS
A total of 1,442 participants were randomly assigned to one of four interventions: 1) MET (1,700 mg/day) plus MedDiet intervention (MET+MedDiet); 2) placebo plus MedDiet intervention; 3) MET (1,700 mg/day) alone; and 4) placebo alone. Participants were followed up for 3 years on average. The primary outcome was the cumulative incidence of major noncommunicable diseases (including type 2 diabetes, cardiovascular diseases, and cancer). Secondary outcomes were the incidence of type 2 diabetes and the changing prevalence of metabolic syndrome.

RESULTS
The crude incidence of the major noncommunicable diseases was 6.7 cases per 100 person-years in the MET+MedDiet group, 6.9 in the MET alone group, 13.3 in the placebo plus MedDiet group, and 11.3 in the placebo group. The differences were fully explained by the reduction of type 2 diabetes, which was 80% and 92% lower in the MET and MET+MedDiet groups, respectively, compared with placebo.

CONCLUSIONS
The use of 1,700 mg/day MET is effective to prevent diabetes in people selected on the basis of metabolic syndrome.
Quality Of Dutch Eggplant Fruit Dodol With Added Sugar
Authors: Saputri Yanti Aimi Dwi , Holinesi Rahmi , Gusnita Wiwik , Siregar Juliana 
Published: December 2024

Fruit dodol is a type of processed agricultural product that is semi-wt, white to brown in color, made from a mixture of sticky rice flour, sugar and coconut milk. This ressearch aims to analyze the quality of Dutch eggplant dodol bg adding variations of sugar of 0 gr, 100 gr, 150 gr and 200 gr. Regarding the quality of shape, color, aroma, texture and taste of dodol This type of research is a pure experiment with a completely randomized design (RAL) method consisting of 4 treatment and 3 repetitions, to analyze the quality of tamarillo fruit dodol with variations in the addition of sugar. organoleptic involving 15 students of Culinary Management, Family Welfare Science. The data obtained was then tabulated and continued with ANOVA, if F count > F table then continued with the Duncan test. The results of the research showed that the use of variations in sugar content on the quality of Dutch eggplant dodol had a significant effect on the quality of color and taste. Meanwhile, the shape, aroma and texture indicators did not have a significant effect. The highest overall achievement scores were neat shape 3.33 (200 gr), heart red color 3.83 (200 gr), tamarillo fruit aroma 2.91 (200 gr), chewy texture 3.33 (200 gr), and sweet taste 3.24 (200 gr), tamarillo fruit taste 3.58 (200 gr). The results of the quality of Dutch eggplant dodol with variations in the addition of the best sugar content were in the fourth treatment (X3) with variations in the addition of 200 gr of sugar).