bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRATEGI KOMUNIKASI HIJABERS SEMARANG DALAM MENSYIARKAN HIJAB PADA MUSLIMAH MUDA DI SEMARANG
Authors: Baroroh Ummul , Hendro W Nur Cahyo , Ghoida Nur Afifah 
Published: February 2019

<p><em>Communication strategy Hijabers Semarang not yet fully use communication strategy, because it does not have a foundation that is structured in terms of media and audience selection and in the evaluation process. However, the process has changed the interest of young Muslim women to use hijab. In formulating a communication strategy, In the preparation of the message, Hijabers Semarang raised the theme that is currently actual among young muslimah, so this makes additional value for Hijabers Semarang among young women themselves. The method used by Hijabers Semarang in delivering hijab syiar to young Muslim women is by Redundancy method, by spreading the broadcast repeatedly to be easily remembered by young muslimah. Canalizing, by plunging directly into the field involving Semarang Hijabers members and committees, to be able to determine and identify similarities and differences so that Hijabers Semarang is easier to make adjustments with audiences. Used strategy persuasive, educative and informative. Hijabers Semarang take advantage of various social media such as facebook, twitter, instagram, and web blog.</em></p><p>-------------------------------------------------------------------------------------</p><p>Strategi komunikasi Hijabers Semarang belum seutuhnya menggunakan strategi komunikasi, karena tidak mempunyai landasan yang terstruktur dalam hal pemilihan media dan khalayak serta dalam proses evaluasi. Akan tetapi, proses yang terjadi telah berhasil mengubah minat muslimah muda untuk menggunakan hijab. Dalam menyusun strategi komunikasi, Hijabers Semarang mengenal khalayak dengan cara survei atau mendatangi langsung sasaran dan mengomunikasikan dengan pihak sasaran. Pada penyusunan pesan, Metode yang digunakan Hijabers Semarang dalam menyampaikan syiar hijab pada muslimah muda adalah dengan metode <em>Redundancy, </em>dengan menyebarkan <em>broadcast </em>berulang-ulang kali agar mudah diingat oleh muslimah muda<em>. Canalizing, </em>dengan terjun langsung ke lapangan yang melibatkan anggota dan komite Hijabers Semarang, untuk dapat menentukan dan mengidentifikasi persamaan dan perbedaan sehingga Hijabers Semarang lebih mudah melakukan penyesuaian dengan khalayak. <em>Persuasif</em>, pada kegiatan <em>hijab and beauty class </em>dan Gerakan Seribu Kerudung, khalayak dipengaruhi dengan jalan membujuk dan digugah baik pikiran maupun perasaan. Strategi yang digunakan bersifat persuasive, edukatif dan informative. Hijabers Semarang</p><p>memanfaatkan berbagai media sosial seperti <em>facebook, twitter, instagram, </em>dan <em>web blog.</em></p>
COMMUNITY DEVELOPMENT DENGAN BERMEDIA SECARA SANTUN
Authors: Rahmi Amelia 
Published: February 2019

<p><em>The existence of mass media has been attached to the life of modern society. The majority of mass media managed to gain material advantage and non-material at once. However, most media managers prefer material gains rather than materials,such as building youth morale, instilling simplicity, maintaining culture and upholding beliefs responsibly.There are not many media In Indonesia that are cmmitted in community development. Republika is one of them. who seek to build society by combining modernmanagement with Islamic values. Referring to the Vision, and the ethical code of Republika's journalistic profession encourages the formation of a balanced community, both physically and spiritually, educating and enlightening, criticizing without hurting.Implementation of the Code of Ethics Journalism is concerned Republika, seen from his caution in diction for news headlines and description of the news. Nevertheless still found some violations of the KEJ, namely on the principle of balance and respect the principle of presumption of innocence.</em></p><p>----------------------------------------------------------------------------------------</p><p>Keberadaan media massa telah melekat pada kehidupan masyarakat modern. Mayoritas media massa dikelola untuk mendapatkan keuntungan material dan non material sekaligus. Namun demikian kebanyakan pengelola media lebih mengutamakan keuntungan material dari pada non material, seperti membangun moral para pemuda, menanamkan kesederhanaan, menjaga budaya dan menegakkan keyakinan secara bertanggung jawab. Di Indonesia tidak banyak media yang berkomitmen pada pengembangan masyarakat. Republika merupakan salah satu surat kabara yang menggabungkan manajemen modern dengan nilai Islami untuk membangun komunitas. Surat kabar tersebut tetap aksis ditengah kompetisi yang ketat saat ini.Mengacu pada visi, dan kode etik profesi jurnalistik, Republika mendorong terbentuknya komunitas yang terbangun secara seimbang, baik fisik maupun spiritualnya, mendidik dan mencerahkan, mengkritisi tanpa menyakiti. Implementasi Kode Etik Jurnalistik sangat diperhatikan Republika, terlihat dari kehati-katiannya dalam diksi untuk judul berita maupun deskripsi beritanya. Namun demikian masih ditemukan beberapa pelanggaran KEJ, terletak pada prinsip keseimbangan dan menghormati asas praduga tak bersalah.</p>
SHOWCASING SOCIAL PIETY: BETWEEN CHARITY OF THE HAVES AND RIGHTS OF THE HAVE-NOTS
Authors: Ridho Miftahur 
Published: February 2019

<p><em>Religion based charity organizations, including those inspired by the Islamic teachings regarding caring for others, are prevalent around the world. They play significant role both in supporting the state to deliver social welfare services to the poor and the less fortunate and sidestepping or competing with the state in such provision. This paper, thus, aims at exploring the dynamic interplay between Islamic teachings regarding charitable practices and social welfare services provided by the state. Discussion on this paper suggests that Islamic charitable practices such as Zakat, shadakah, and others, can be observed through different lenses; as a charity of the rich and as rights of the poor. In Indonesia and other Muslim countries, such giving practices are widely accepted as charity of the rich partly because the idea of providing social welfare to the poor is perceived as the duty of the state. Hence, the rights of the poor lies on the obligation of the state, not the rich.</em></p><p> </p>
ESTRATÉGIAS DE PRECIFICAÇÃO EM MEIOS DE HOSPEDAGEM: UMA REVISAO HISTÓRICO-CONCEITUAL.
Authors: Leite Andressa Ferreira Ramalho 
Published: February 2019

O presente trabalho tem como objetivo central da pesquisa, analisar as estratégias de precificação adotadas cronologicamente pelos meios de hospedagem, buscando com isso, a compreensão do futuro da precificação a partir da análise do modelo desenvolvido pelo autor Stowe Shoemaker. O objetivo geral dessa pesquisa está norteado pelos seguintes objetivos específicos: a) Identificar quais são as principais estratégias de precificação relatadas nas pesquisas científicas sobre a temática no período proposto para esse estudo; b) Descrever e analisar as estratégias de precificação propostas, segundo o modelo de Stowe Shoemaker. O referencial teórico desse trabalho baseia-se no estudo das principais publicações nacionais e internacionais sobre o setor hoteleiro, marketing turístico, estratégias de precificação, valor agregado e percebido pelo o cliente. A metodologia aplicada apresenta caráter descritivo e exploratório com abordagem qualitativa de dados, almejando obter resultados através da pesquisa bibliográfica e documental. O recorte temporal dessa pesquisa compreende-se entre 1970 á 2018, por se tratar do período de maior realização de pesquisas sobre o tema central desse estudo. Sobre as considerações finais dessa pesquisa exploratória, observou-se um número significativo de estudos e estratégias diversas de precificação, em maior parte, internacionais. Contudo, é notável a necessidade de maiores pesquisas que desenvolvam a temática no Brasil, visto a escassez de trabalhos nacionais. PALAVRAS- CHAVE: Hotelaria; Marketing; Valor; Precificação.
Quality of Life and Social Support in Women with Urinary Incontinence
Authors: Makara-Studzińska Marta , Madej Agata , Trypka Elżbieta , Leszek Jerzy , Tarasov Vadim V. , Ashraf Ghulam M. , Yarla Nagendra Sastry , Samsonova Anna N. , Aliev Gjumrakch 
Published: February 2019

Background:Urinary incontinence (UI) is a serious medical and social problem for about one-third of women in the world population. It is one of the most common chronic diseases of women. Despite significant improvement in the diagnosis and treatment of this illness, women continue to struggle with the stigma associated with incontinence. Research conducted in the last few years shows the importance of social support in respect of the illness.Aim:The purpose of this study was to determine how people perceive the disease and the influence of social support to deal with UI.Materials and Methods:The study involved 200 women in the age range of 34-78 with a diagnosis of incontinence. All women agreed to fill out an anonymous questionnaire, Acceptance of Illness Scale (AIS) and Disease-Related Social Support Scale (DSRSS). The obtained results were subject to statistical analysis.Results:The greater the social support, the lesser the tendencies to judge the condition in terms of harm. Material support among respondents makes it easier for them to distance themselves from UI. Women having a sense of spiritual, emotional, and global support information found it easier to come in terms with UI.Conclusion:There is a relationship between the perception of disease for women, and social support received by women. Awareness of the availability support in disease allows peaceful thinking about a situation as difficult as UI.
Evaluation of the Reliability of Interim PET/CT in the Hodgkin Lymphoma
Authors: Eren Rafet , Gündoğan Cihan , Aslan Ceyda , Koç Alper , Doğu Mehmet Hilmi , Altındal Şermin , Yokuş Osman , Suyanı Elif , Çermik Tevfik Fikret 
Published: February 2019

Introduction:
Positron-emission tomography (PET)/computerized tomography (CT)
with 18F-fludeoxyglucose (FDG) has been come into use for risk assessment of Hodgkin lymphoma
(HL) patients in recent years. The aim of our study is to evaluate the reliability of interim PET results
according to Deauville score (DS), and also to compared PET findings with tumor reduction
on CT.

Methods:
Forty-two HL patients (median 39, range 19-75 y, 27 M, 15 F) were retrospectively
evaluated with pre, interim and post-treatment PET/CT imaging. PET/CT imaging was obtained 60
min after the intravenous administration of 3.7-5.2 MBq/kg 18F-FDG.

Results:
The negative predictive value of the interim PET was 89%. Four (10.5%) of the 38 interim
PET-negative patients became post-treatment PET-positive. According to CT, 15 patients were in
complete remission (CR), 27 (64.6%) patients were in partial remission (PR) or stable disease
(SD).

Conclusion:
The negative predictive value of interim PET was not satisfactory considering the
treatment rate of over 80% of HL. Additionally, high rate of interim PET-negative patients’ conversion
to PET-positive post-treatment state was considered as unexpected.
Development and Validation of an LC-MS/MS Method for Quantitative Determination of EAI045, A Novel EGFR Inhibitor, in Rat Plasma
Authors: Chu Zixuan , Xue Mingxing , Xiong Shan 
Published: February 2019

Background:
EAI045 is the fourth-generation epidermal growth factor receptor tyrosine
kinase inhibitor (EGFR TKI), which can overcome acquired resistance to the third-generation EGFR
TKIs and is the first allosteric inhibitor that targets T790M and C797S EGFR mutants.

Methods:
A rapid and sensitive LC-MS/MS method was established and validated for the quantification
of EAI045 in rat plasma. Chromatographic separation was carried out at 25°C on a Hypersil GOLD C18
column (50 mm × 2.1 mm, 3 μm) and eluted on a gradient mobile phase of water (containing 0.1% formic
acid) and acetonitrile at a flow rate of 0.5 mL/min. The mass spectrometer was operated in the positive
ESI mode and selected reaction monitoring mode.

Results:
The assay was validated over a concentration range of 1.0 - 1000 ng/mL for EAI045 with a
lower limit of quantification (LLOQ) of 1.0 ng/mL. The intra- and inter-batch accuracy for the EAI045
ranged from 92.25% to 97.18% and 95.94% to 102.69%, and the intra- and inter-batch precision for the
EAI045 ranged from 1.41% to 4.57% and 5.18% to 6.37%, respectively. The extraction recovery, matrix
effect and stability met all requirements of the guidelines for bioanalytical method validation.

Conclusion:
The rapid and sensitive LC-MS/MS method was successfully applied in a pharmacokinetic
study of EAI045 following oral administration (5 mg/kg) to rats.
Biological and Toxicological Evaluation of N-(4methyl-phenyl)-4-methylphthalimide on Bone Cancer in Mice
Authors: Santin José R. , da Silva Gislaine F. , Pastor Maria V.D. , Broering Milena F. , Nunes Roberta , Braga Rodolpho C. , de Sousa Iury T.S. , Stiz Dorimar S. , da Silva Kathryn A.B.S. , Stoeberl Luis C. , Corrêa Rogério , Filho Valdir C. , dos Santos Carlos E.M. , Quintão Nara L.M. 
Published: February 2019

Background:
It was recently demonstrated that the phthalimide N-(4-methyl-phenyl)-4-
methylphthalimide (MPMPH-1) has important effects against acute and chronic pain in mice, with a mechanism
of action correlated to adenylyl cyclase inhibition. Furthermore, it was also demonstrated that phthalimide derivatives
presented antiproliferative and anti-tumor effects. Considering the literature data, the present study
evaluated the effects of MPMPH-1 on breast cancer bone metastasis and correlated painful symptom, and provided
additional toxicological information about the compound and its possible metabolites.

Methods:
In silico toxicological analysis was supported by in vitro and in vivo experiments to demonstrate the
anti-tumor and anti-hypersensitivity effects of the compound.

Results:
The data obtained with the in silico toxicological analysis demonstrated that MPMPH-1 has mutagenic
potential, with a low to moderate level of confidence. The mutagenicity potential was in vivo confirmed by
micronucleus assay. MPMPH-1 treatments in the breast cancer bone metastasis model were able to prevent the
osteoclastic resorption of bone matrix. Regarding cartilage, degradation was considerably reduced within the
zoledronic acid group, while in MPMPH-1, chondrocyte multiplication was observed in random areas, suggesting
bone regeneration. Additionally, the repeated treatment of mice with MPMPH-1 (10 mg/kg, i.p.), once a day
for up to 36 days, significantly reduces the hypersensitivity in animals with breast cancer bone metastasis.

Conclusion:
Together, the data herein obtained show that MPMPH-1 is relatively safe, and significantly control
the cancer growth, allied to the reduction in bone reabsorption and stimulation of bone and cartilage regeneration.
MPMPH-1 effects may be linked, at least in part, to the ability of the compound to interfere with adenylylcyclase
pathway activation.
Overexpression of Hepassocin in Diabetic Patients with Nonalcoholic Fatty Liver Disease May Facilitate Increased Hepatic Lipid Accumulation
Authors: Abdelmoemen Ghada , Khodeir Samy Abdelkader , Zaki Ahmed Nabil , Kassab Maha , Abou-Saif Sabry , Abd-Elsalam Sherief 
Published: February 2019

Background & Aims: Insulin resistance is the real determinant of both Nonalcoholic fatty
liver disease (NAFLD) and diabetes, and can facilitate the accumulation of triglycerides in the liver.
Overexpression of hepassocin (HPS) increased the accumulation of hepatic fat and NAFLD activity
scores (NAS) in mice. The aim of this study was to investigate the relationship between hepassocin and
steatosis of the liver in diabetic patients with or without NAFLD in humans.

Methods:
The study enrolled 60 patients plus 20 healthy controls that were divided into 4 groups: Group
I: included 20 patients who were diagnosed as diabetes mellitus type 2, Group II: included 20 patients
who were diagnosed as nonalcoholic fatty liver disease (NAFLD), Group III: included 20 patients who
were diagnosed as diabetes type 2 and NAFLD, and Group IV (control group): included 20 healthy
person or controls who were matched in age and sex with patients group. All patients and controls were
subjected to full history taking, thorough clinical examination, laboratory investigations including measurement
of serum hepassocin in peripheral blood by ELISA technique.

Results:
There was a significant overexpression of serum hepassocin in patients with type 2 diabetes
and NAFLD patients (Group 3) more than diabetic patients (Group 1) and even more than non-alcoholic
fatty liver disease (Group 2).

Conclusion:
This study provides evidence that increased HPS may facilitate increased hepatic lipid
accumulation with NAFLD and type 2 diabetes.
Silibinin Ameliorates Fructose-induced Lipid Accumulation and Activates Autophagy in HepG2 Cells
Authors: Li Yang , Ren Luping , Song Guangyao , Zhang Pu , Yang Liying , Chen Xinwei , Yu Xiaolei , Chen Shuchun 
Published: February 2019

Background:
Autophagy was recently regarded as a potential mechanism in nonalcoholic
fatty liver disease. Silibinin (SIL), a natural flavonoid, has been used to prevent nonalcoholic fatty liver
disease, however, the underlying mechanism is unclear. The aim of the present study was to explore
the effect of SIL on hepatic steatosis and the possible link with autophagy.

Methods:
The degree of hepatic steatosis in HepG2 cells was observed by oil-red O staining and
triglyceride content. The effect of SIL on autophagy was tested by the Autophagy Detection Kit, and
the expression of sterol regulatory element binding protein 1 (srebp-1), Fatty Acid Synthase (Fas), light
chain 3, beclin-1, p62, AMP-activated Kinase (AMPK), and mammalian Target Of Rapamycin
(mTOR) was examined by western blots.

Results:
The lipid accumulation of HepG2 cells increased significantly in the high-fructose group
compared to the control group. After SIL intervention, lipid accumulation was decreased. Using a fluorescence
microscope, SIL was found to induce autophagy. Compared to control, the expressions of
srebp-1, Fas, and phosphorylated-mTOR were increased by high-fructose, while the expressions of
light chain 3 and beclin-1 decreased and srebp-1, Fas, and p62 were increased by autophagy inhibition.
In contrast, opposite results were found in the SIL intervention group. The protein content of phosphorylated-
mTOR was decreased, while phosphorylated-AMPK was increased in the SIL group compared
to the high-fructose group.

Conclusion:
SIL can reduce lipid accumulation in HepG2 cells exposed to high-fructose by inducing
autophagy. The AMPK/mTOR signaling pathway could be one of the underlying molecular mechanisms.
Shape Adaptable Medical Multimedia Processing
Authors: Abboud Ali J. 
Published: February 2019

Introduction:Electronic medical healthcare systems are becoming the backbone of health organizations over the world. The huge amounts of medical multimedia produced by these systems especially images and videos are transmitted by the computer networks that connect these systems. The variability in the shape and texture of transferred medical multimedia data needs adaptable procedures to process these data efficiently. In other words, these procedures must adjust automatically based on the shape of region of interests in the medical multimedia images to cope with fast changes in the healthcare environments. In this paper, we have proposed shape adaptable watermarking approaches for medical multimedia processing systems. The medical images generated by X-rays, MRI and CT modalities are used in our experiments to test proposed approaches. In addition, these approaches were tested under different kinds of signal processing and geometric attacks. The comparative comparison of our proposed approaches with state-of-art approaches proved the superiority and capability of our approaches to adjust the number of selected subands of medical cover image to embed and extract the hospital watermark logos.Background and Objective:The development of an adjustable approach to process medical multimedia signals for healthcare system. The aim of this research is to select adaptably the number of subands of cover image to hide the information of hospital logo watermark inside them such that embedded watermarks can resist different kinds of attacks.Method:The proposed adjustable approach consists of suband selection method, criterion, embedding and extraction procedures, DWT transform, attacks, evaluation metrics,etc.Results & Conclusion:It provides robust and adjustable method to embed and extract watermark logo at different resolution levels of cover medical image and uses with images of different sizes and modalities.
Clinical Evaluation of Dry Eye Syndrome in Patients with Proliferative Diabetic Retinopathy and Laser Therapy Indication
Authors: Dutra Barbara de Araujo Lima , Carneiro Carolina Lyra Barreira , Gomes Mariana Studart Mendonça , Nagashima Rodrigo Dantas , Machado Andre Juca , Crispim Joao 
Published: February 2019

Background:
Studies have shown a higher incidence of dry eye among patients with diabetes compared to patients without diabetes. However, information regarding dry eye in patients with proliferative diabetic retinopathy and laser therapy indication is not sufficient.

Objective:
To estimate the clinical manifestation of dry eye syndrome in patients with proliferative diabetic retinopathy and laser therapy indication.

Method:
A cross-sectional study was performed during a local evaluation campaign of diabetic patients with vision disabilities at the Instituto Cearense de Oftalmologia in Fortaleza, CE, Brazil. Patients with proliferative diabetic retinopathy and laser therapy indication were included in the study. An anamnesis directly to dry eye complaints was performed, and eligible participants completed the Ocular Surface Disease Index (OSDI) questionnaire. The slit lamp examination was performed with fluorescein staining; the tear break-up time (TBUT) was measured, and conjunctiva and corneal was evaluated using Rose Bengal (RB) staining. Finally, the Schirmer I test was performed.

Results:
Twenty-five patients were included in the study with a diagnostic time of Diabetes Mellitus ranged from 1 to 35 years, with an average of 17.2 ± 8.7 years. In our sample, 14 patients (56%) reported glycemic control with insulin, while 11 patients (44%) had oral hypoglycemic agents. The most prevalent complaint was blurred vision (96% of patients) followed by low visual acuity (92%). A less prevalent complaint was pain (44%). The mean OSDI score was 49.4 ± 24.2. TBUT was less than 10 seconds in 21 patients (84%), and RB staining grade was more than 3 in 13 patients (52%). The results of the Schirmer I test ranged from 2 to 35 mm, with a mean of 13.57 ± 9.78 mm. It was smaller than 10 mm in 15 patients (60%).

Conclusion:
The frequency of manifestation of dry eye syndrome was very common in patients with proliferative diabetic retinopathy and laser therapy indication. Ocular surface care should be provided for those patients with significant ocular morbidity.