bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silk Fibroin/Orange Peel Foam: An Efficient Biocomposite for Water Remediation
Authors: Campagnolo Laura , Morselli Davide , Magrì Davide , Scarpellini Alice , Demirci Cansunur , Colombo Massimo , Athanassiou Athanassia , Fragouli Despina 
Published: October 2018

AbstractA novel approach for the valorization of orange peel waste for the removal of aqueous organic pollutants is presented herein. The orange peel is combined with silk fibroin in order to obtain alcogels, which are successfully converted into highly porous biocomposite foams upon supercritical CO2 drying. The biocomposite shows a Brunauer–Emmett–Teller specific surface area of 174.45 m2 g−1 and can absorb three times its weight in water. The resulting adsorbents can adsorb methylene blue from water with a maximum adsorption capacity of 113.8 ± 12.5 mg g−1, with the orange peel activity well preserved in the polymeric matrix. The spectroscopic studies performed show that the methylene blue molecules are adsorbed in the form of monomers on the surface of the biocomposite foams, forming a monolayer as suggested by the Langmuir isotherm model. Although the agrowaste powders are already confirmed to be promising biosorbents for the removal of pollutants from water, the difficulties caused by their recovery after the water treatment may limit their manageability and applicability. With this study, such limitations can be overcome thanks to the incorporation of the powder in a solid porous system, without significantly compromising the dye adsorption capacity of the incorporated orange peel.
A Nonflammable Na+‐Based Dual‐Carbon Battery with Low‐Cost, High Voltage, and Long Cycle Life
Authors: Jiang Xiaoyu , Liu Xingwei , Zeng Ziqi , Xiao Lifen , Ai Xinping , Yang Hanxi , Cao Yuliang 
Published: October 2018

AbstractDual‐carbon batteries provide a new perspective on energy storage technology due to their high voltage and low cost. Herein, a novel Na+‐based dual‐carbon battery (Na+‐DCB) is developed based on a nonflammable trimethyl phosphate (TMP) electrolyte with sodium bis(trifluoromethanesulfonate)imide salt (NaTFSI). As the molar ratio of NaTFSI/TMP increases to 1:2, the graphite cathode shows a high reversible capacity of 52.9 mAh g−1, excellent rate capability (21.0 mAh g−1 at 2000 mA g−1) and superstability cycling performance (≈100% capacity retention after 750 cycles). In addition, a stable solid electrolyte interface (SEI) film is formed on the surface of hard carbon anode by the preferential reductive decomposition of TFSI−, which suppresses decomposition of TMP. In this case, the Na+‐DCB is capable to provide an operation voltage of 4.0 V and excellent electrochemical performance. This work provides new insights for developing new dual‐carbon batteries with safety, low cost, and absence of heavy metals.
The role of galactomannan Aspergillus antigen in diagnosing acute invasive fungal sinusitis
Authors: Melancon C. Claire , Lindsey Jennifer , Russell Gregory B. , Clinger John D. 
Published: October 2018

BackgroundPathologic diagnosis remains the gold standard for final diagnosis of acute invasive fungal sinusitis (AIFS); however, other less invasive tests could suggest the presence of AIFS in at‐risk populations where early diagnosis is crucial. Serum galactomannan Aspergillus antigen has been shown to correlate with a diagnosis of invasive pulmonary aspergillosis; however, it has not adequately been evaluated in regard to AIFS. The objective of this study is to evaluate the statistical relevance of galactomannan in predicting diagnosis of AIFS.MethodsThis study was a retrospective review of pathologic records using Co‐Path from 2006 to 2017, incorporating 2 separate searches with designated criteria identifying patients who received pathologic evaluation for invasive fungal sinusitis. Electronic medical records were subsequently reviewed. After exclusions isolating at‐risk populations and removing duplications, 78 cases were reviewed using the indicated search criteria. Of these, 38 met further criteria of having had both pathologic evaluation and galactomannan analysis. Statistical variables were assessed, as well as all‐cause mortality. Peak and closest galactomannan levels were evaluated.ResultsOverall, galactomannan had a sensitivity of 44.8% (95% confidence interval [CI], 26.5% to 64.3%), specificity of 100% (95% CI, 66.4% to 100%), positive predictive value of 100% (95% CI, 74.3% to 100%), and negative predictive value of 36% (95% CI, 18.0% to 57.5%). No significant association was observed in galactomannan status and mortality in this patient population.ConclusionPositive serum galactomannan can be an indication of AIFS in patients with a high clinical suspicion. In our study, a positive galactomannan always correlated with a positive pathologic diagnosis. However, given its low sensitivity, one must use caution in relying on galactomannan as a screening tool in diagnosis of AIFS.
2,6‐Dimercuriphenol as a Bifacial Dinuclear Organometallic Nucleobase
Authors: Ukale Dattatraya Uttam , Lönnberg Tuomas 
Published: October 2018

AbstractA C‐nucleoside having 2,6‐dimercuriphenol as the base moiety has been synthesized and incorporated into an oligonucleotide. NMR and UV melting experiments revealed the ability of this bifacial organometallic nucleobase surrogate to form stable dinuclear HgII‐mediated base triples with adenine, cytosine, and thymine (or uracil) in solution as well as within a triple‐helical oligonucleotide. A single HgII‐mediated base triple between 2,6‐dimercuriphenol and two thymines increased both Hoogsteen and Watson–Crick melting temperatures of a 15‐mer pyrimidine⋅purine*pyrimidine triple helix by more than 10 °C relative to an unmodified triple helix of the same length. This novel binding mode could be exploited in targeting certain pathogenic nucleic acids as well as in DNA nanotechnology.
Bacteriorhodopsin‐Inspired Light‐Driven Artificial Molecule Motors for Transmembrane Mass Transportation
Authors: Xie Ganhua , Li Pei , Zhao Zhiju , Kong Xiang‐Yu , Zhang Zhen , Xiao Kai , Wang Huanting , Wen Liping , Jiang Lei 
Published: October 2018

AbstractIn nature, biological machines and motors can selectively transport cargoes across the lipid membranes to efficiently perform various physiological functions via ion channels or ion pumps. It is interesting and challengeable to develop artificial motors and machines of nanodimensions to controllably regulate mass transport in compartmentalized systems. In this work, we show a system of artificial molecular motors that uses light energy to perform transmembrane molecule transport through synthetical nanochannels. After functionalizing the polymer nanochannels with azobenzene derivatives, these nanomachines exhibit autonomous selective transport behavior over a long distance upon simultaneous irradiation with UV (365 nm) and visible (430 nm) light. With new strategies or suitable materials for directed molecular movement, such device can be regarded as a precursor of artificial light‐driven molecular pumps.
Dual‐Mode Light Transduction through a Plastically Bendable Organic Crystal as an Optical Waveguide
Authors: Catalano Luca , Karothu Durga Prasad , Schramm Stefan , Ahmed Ejaz , Rezgui Rachid , Barber Timothy J. , Famulari Antonino , Naumov Panče 
Published: October 2018

AbstractAn anthracene derivative, 9,10‐dicyanoanthracene, crystallizes as fluorescent needle‐like single crystals that can be readily plastically bent in two directions. Spatially resolved photoluminescence analysis revealed that this material has robust optoelectronic properties that are preserved upon extreme crystal deformation. The highly flexible crystals were successfully tested as efficient switchable optical waveguiding elements for both active and passive light transduction, and the mode of operation depends on the wavelength of the incident light. This prototypical dual‐mode organic optical crystalline fiber brings mechanically compliant molecular organic crystals closer to applications as novel light‐transducing media for wireless transfer of information in all‐organic micro‐optoelectronic devices.
Towards a Spectrally Customized Photoresponse from an Organic–Inorganic Hybrid Ferroelectric
Authors: Ji Chengmin , Liu Sijie , Han Shiguo , Tao Kewen , Sun Zhihua , Luo Junhua 
Published: October 2018

AbstractPhotosensitive organic–inorganic hybrid ferroelectrics are emerging as a new class of promising materials with a broad spectral response (e.g., visible light, UV light, and IR light) for optoelectronic applications. However, spectrally customized photoresponses in ferroelectrics have not been achieved. Herein, we report a photosensitive organic–inorganic hybrid ferroelectric, (diisobutylammonium)3ClCoCl4 (1), with a notable spontaneous polarization of approximately 4.6 μC cm−2 and high Curie temperature (Tc=372.5 K). More interestingly, it features spectrally selective absorption at specific wave bands ranging from 550 to 700 nm with a large absorption coefficient, which was assigned to the d–d transition of Co2+ from the 4A2 to the 4T1 (P) state. It is emphasized that 1 shows spectrally customized photosensitivity with distinct photocurrent generation under light illumination at 550–700 nm. This is the first hybrid photosensitive ferroelectric with a spectrally customized photoresponse. This finding should lead to innovative applications of hybrid photosensitive ferroelectrics, especially towards spectrally selective optoelectronic devices.
Metal–organic framework‐derived cobalt and nitrogen co‐doped porous carbon with four‐coordinated Co–Nx for efficient acetylene hydrochlorination
Authors: Dong Xiaobin , Zhao Chaoyue , Guan Qingxin , Li Wei , Xu Xiufang 
Published: October 2018

Industrial production of vinyl chloride through acetylene hydrochlorination is a dominating technique in coal‐rich areas, but its development is severely restricted by the use of toxic mercury chloride (HgCl2) catalyst. Inspired by the fact that doped carbon materials active in acetylene hydrochlorination often have good performance in the oxygen reduction reaction, a series of cobalt and nitrogen co‐doped porous carbon catalysts prepared by pyrolysis of bimetallic ZIFs based on ZIF‐8 and ZIF‐67 under N2 were applied in acetylene hydrochlorination. The catalytic activities of the co‐doped catalysts varied with Co addition, and the highest acetylene conversion could be up to 83% with a space velocity of 2.6 ml g−1 min−1 at 220°C when a small amount of cobalt was introduced. Results of several characterizations confirmed the existence of Co–Nx in the co‐doped carbons, pointing out that this coordination structure makes the catalysts have better ability to adsorb and activate C2H2. Density functional theory calculation finally proved that C atom adjacent to the N atom in Co–N4 structure is the primary active site in co‐doped catalysts with high activity. We also conclude that the decreased N content caused by Co2N decomposition and the coordination structure change of Co–Nx should be responsible for the gradually worsening performances of the carbon catalysts with further Co addition. Our study provides a new route for improving the performance of N‐doped carbon material in acetylene hydrochlorination and thus enhances its potential for practical application.
Statistical Tests for Integrity Attacks on Cyber‐Physical Systems
Authors: Zeng Qingliang , Pu Shaoning , Zhang Xin 
Published: October 2018

AbstractThis paper is written to show a new detection method for integrity attack on the measurements. It is proved that the normality of the residual error from Kalman filter is equivalent to that of the measurement. Our method utilizes this property and it could not only detect the distribution changes at current time, but also detect the its time correlations. Overall, it is an improved detection method for a wider range of attacks.
Piecewise Polynomial Model Reduction Method for Nonlinear Systems in Time Domain
Authors: Qiu Zhi‐Yong , Jiang Yao‐Lin 
Published: October 2018

AbstractModel order reduction (MOR) of nonlinear systems draws great attention in the past several decades. This paper presents a new MOR method in time domain for nonlinear dynamical systems. The new algorithm is based on the combination of the Taylor series expansion for the state variable x(t) and the trajectory piecewise polynomial technique. Firstly, the nonlinear system is approximated by a piecewise polynomial representation. Then, based on the Taylor series coefficients of x(t), we formulate the projection matrix V for the piecewise polynomial system and the compact model of the piecewise polynomial system is obtained in the following. Besides, error estimation and stability analysis are also presented in this paper. Finally, two nonlinear systems are tested to verify the effectiveness of the algorithm.
14‐3‐3ζ binds to hepatitis B virus protein X and maintains its protein stability in hepatocellular carcinoma cells
Authors: Tang Yufu , Zhang Yibing , Wang Chunhui , Sun Zhongyi , Li Longfei , Dong Jiahong , Zhou Wenping 
Published: October 2018

Abstract14‐3‐3ζ, a phosphopeptide‐binding molecule, is reportedly overexpressed in the cancerous tissues of patients with hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) protein X (HBx) draws intensive attention in HBV‐related HCC because it not only regulates HBV replication, but also promotes carcinogenesis by interacting with various tumor or antitumor molecules. This study is performed to investigate whether and how 14‐3‐3ζ interacts with HBx. The coimmunoprecipitation (Co‐IP) results showed that 14‐3‐3ζ bond to HBx in HBV‐infected Hep3B HCC cells and CSQT‐2 portal vein tumor thrombosis (PVTT) cells. By performing Co‐IP assay in HBV‐free Huh7 cells expressing wild‐type HBx, mutant HBx‐S31A, or HBx‐S31D (serine31 was mutated into alanine31 or aspartic acid31), we found that the phosphorylated serine31 with its near amino acid residues constituted a RPLphosphoS31GP (R, arginine; P, proline; L, leucine; S, serine; G, glycine) motif in HBx for 14‐3‐3ζ docking. This 14‐3‐3ζ‐HBx interaction was partly impaired when Akt signaling transduction was blocked by LY294002. Furthermore, 14‐3‐3ζ silencing augmented HBx ubiquitination and decreased its expression in cancer cells and xenograft tumor. The migratory and invasive abilities of CSQT‐2 cells were inhibited upon 14‐3‐3ζ silencing, whereas partly restored by HBx overexpression. Additionally, 14‐3‐3ζ positively correlated with HBx to be overexpressed in the primary HCC tissues (r = 0.344) and metastatic PVTT (r = 0.348). In summary, findings of this study reveal a novel 14‐3‐3ζ‐HBx interaction in HCC cells and suggest 14‐3‐3ζ as a candidate target for treating HBV‐related HCC.
Effect of functional genetic variants in chemokine decoy receptors on the recurrence risk of breast cancer
Authors: Li Dou‐Dou , Yang Chen , Shao Zhi‐Ming , Yu Ke‐Da 
Published: October 2018

AbstractDuffy antigen receptor for chemokine (DARC) and CCBP2, the two members of chemokine decoy receptor family, restrain cell proliferation and invasion through sequestrating cytotoxic chemokines. Our previous research clarified two functional nonsynonymous single nucleotide polymorphisms (SNPs): rs12075 in DARC and rs2228468 in CCBP2 were significantly correlated with lymph node metastasis. However, the role of their genetic variations on survival of breast cancer remains unclear. In the present study, rs12075 in DARC and rs2228468 in CCBP2 were genotyped in 806 patients with primary breast cancer. The endpoint was recurrence‐free survival (RFS). Cox regression model was used to explore the association between SNPs and patients’ survival. The results revealed that participants with GG genotype in rs12075 appeared a higher recurrence risk compared with AG/AA genotype after adjustment with clinical parameters including lymph node status (AG+AA vs GG: hazard ratio [HR] = 0.54, 95% confidence interval [CI], 0.31‐0.93, P = 0.027). Furthermore, subgroup analysis revealed that GG genotype frequency of rs12075 had a positive correlation with RFS compared with AG/AA genotype (AG+AA vs GG: HR = 0.22, 95% CI, 0.05‐0.91, P = 0.021) in triple‐negative breast cancer (TNBC) subtype but not in other subtypes. No significant association between the genotypic variants and relapse risk was found in rs2228468 (AC+AA vs CC: HR = 0.80, 95% CI, 0.56‐1.14, P = 0.222). There was also no significant difference in survival among rs2228468 polymorphism in any subtypes. Our study suggested that rs12075 could be served as a key predictive factor of recurrence risk in breast cancer, especially for TNBC subtype. Further researches to monitor SNPs will provide further opportunities to determine clinical prognosis.
Risk‐dependent curability of radiotherapy for elderly patients with early‐stage extranodal nasal‐type NK/T‐cell lymphoma: A multicenter study from the China Lymphoma Collaborative Group (CLCG)
Authors: Chen Bo , Zhu Su‐Yu , Shi Mei , Su Hang , Wang Ying , He Xia , Xu Li‐Ming , Yuan Zhi‐Yong , Zhang Li‐Ling , Wu Gang , Qu Bao‐Lin , Qian Li‐Ting , Hou Xiao‐Rong , Zhang Fu‐Quan , Zhang Yu‐Jing , Zhu Yuan , Cao Jian‐Zhong , Lan Sheng‐Min , Wu Jun‐Xin , Wu Tao , Qi Shu‐Nan , Yang Yong , Liu Xin , Li Ye‐Xiong 
Published: October 2018

AbstractBackgroundThe purpose of this study was to determine the curability of early‐stage extranodal nasal‐type NK/T‐cell lymphoma (NKTCL) in response to radiotherapy and non‐anthracycline‐based chemotherapy in elderly patients.MethodsIn this multicenter study from the China Lymphoma Collaborative Group (CLCG) database, 321 elderly patients with early‐stage NKTCL were retrospectively reviewed. Patients received radiotherapy alone (n = 87), chemotherapy alone (n = 59), or combined modality therapy (CMT, n = 175). Patients were classified into low‐ or high‐risk groups using four prognostic factors. Observed survival in the study cohort vs expected survival in age‐ and sex‐matched individuals from the general Chinese population was plotted using a conditional approach and subsequently compared using a standardized mortality ratio (SMR).ResultsRadiotherapy conveyed a favorable prognosis and significantly improved survival compared to chemotherapy alone. The 5‐year overall survival (OS) and progression‐free survival (PFS) were 61.2% and 56.4%, respectively, for radiotherapy compared with 44.7% and 38.3%, respectively, for chemotherapy alone (P < 0.001). The combination of a non‐anthracycline‐based chemotherapy regimen and radiotherapy significantly improved PFS compared to combination of an anthracycline‐based chemotherapy regimen and radiotherapy (71.2% vs 44.2%, P = 0.017). Low‐risk patients following radiotherapy (SMR, 0.703; P = 0.203) and high‐risk patients who achieved PFS at 24 months (SMR, 1.490; P = 0.111) after radiotherapy showed survival equivalent to the general Chinese population.ConclusionsOur findings indicate a favorable curability for this malignancy in response to radiotherapy and non‐anthracycline‐based chemotherapy, providing a risk‐adapted follow‐up and counsel scheme in elderly patients.
Synthesis and Spectral Characterization of Asymmetric Azines Containing a Coumarin Moiety: The Discovery of New Antimicrobial and Antioxidant Agents
Authors: Ristić Milenko N. , Radulović Niko S. , Dekić Biljana R. , Dekić Vidoslav S. , Ristić Novica R. , Stojanović‐Radić Zorica 
Published: October 2018

AbstractNine unsymmetrical azines containing a coumarin moiety were prepared by the reaction of the hydrazone of 4‐hydroxy‐3‐acetylcoumarin with differently substituted aromatic aldehydes. The azines were fully spectrally characterized, including a complete assignment of 1H‐ and 13C‐NMR resonances, and were assessed for their acute toxicities in the Artemia salina model. Their free radical scavenging activities were tested in the DPPH assay, and in vitro antimicrobial activities were determined against seven bacterial and two fungal strains. The azines containing a p‐hydroxyphenyl group were shown to be the most effective antimicrobial agents, and in the case of resistant strains of Staphylococcus aureus and Acinetobacter baumannii, the activity was comparable to that of chloramphenicol. The derivative having a 3,5‐dimethoxy‐4‐hydroxyphenyl group exhibited pronounced antioxidant power reacting rapidly and in 1 : 1 mol ratio with the DPPH radical.
Post‐translational Assembly of Protein Parts into Complex Devices by Using SpyTag/SpyCatcher Protein Ligase
Authors: Sutherland Ashley R. , Alam Md. Kausar , Geyer C. Ronald 
Published: October 2018

AbstractExploiting the innate modularity of proteins has allowed advances across the fields of synthetic biology and biotechnology. By using standardized protein components as building blocks, complex, multiprotein assemblies with sophisticated functions can be generated; feats previously not possible with strictly genetic‐engineering approaches. The development of strategies for protein assembly is accelerating, pushing the boundaries of protein architecture. SpyTag and SpyCatcher protein ligase is a recent advance in this field that allows plug‐and‐play modularity by harnessing post‐translational protein assembly. Herein, we review the latest applications of this powerful tool including novel enzyme assemblies, modularizing protein display, and the generation of antibody and antibody‐like “devices” by using SpyTag/SpyCatcher technology.
Klotho gene‐modified BMSCs showed elevated antifibrotic effects by inhibiting the Wnt/β‐catenin pathway in kidneys after acute injury
Authors: Zhang Feng , Wan Xin , Cao Yi‐Zhi , Sun Dong , Cao Chang‐Chun 
Published: October 2018

AbstractKlotho is a protein primarily expressed in renal tubular epithelial cells. Studies have suggested that Klotho is an antiaging protein that reduces renal fibrosis after acute kidney injury (AKI) and inhibits stem cell senescence. Bone marrow mesenchymal stem cells (BMSCs) have consistent proliferation ability and multidirectional differentiation ability and have been used to treat tissue injury. Thus, we hypothesized that Klotho expressed in BMSCs could increase the renal protective effects of BMSCs. To verify the hypothesis, we isolated BMSCs from C57BL/6 mice, transfected them with Klotho‐GFP‐adenovirus and investigated the change in BMSC proliferation. We then transplanted Klotho‐GFP‐BMSCs into mice with AKI and investigated the therapeutic effect compared with that of sham‐treated mice and GFP‐BMSC‐transplanted mice. Kidney fibrosis after ischemia/reperfusion injury (IRI) was relieved by BMSC transplantation, and the antifibrotic effect of BMSCs was significantly enhanced by overexpressing the Klotho gene. Mechanistic studies showed that Klotho increased pluripotency gene expression in BMSCs. Klotho produced by Klotho‐GFP‐BMSCs inhibited the Wnt/β‐catenin pathway in renal tubular epithelial cells (TECs). Klotho‐GFP‐BMSCs showed increased proliferative ability and more potent immuno‐regulation ability than did GFP‐BMSCs. Our findings suggested that Klotho gene‐modified BMSCs may be a better choice for cell therapy after AKI.
Novel mutation in CCBE 1 as a cause of recurrent hydrops fetalis from Hennekam lymphangiectasia‐lymphedema syndrome‐1
Authors: Melber Dora J. , Andreasen Tara S. , Mao Rong , Tvrdik Tatiana , Miller Christine E. , Moore Thomas R. , Woelkers Douglas A. , Lamale‐Smith Leah M. 
Published: October 2018

Key Clinical MessageWhole exome sequencing (WES) was used to determine the etiology of recurrent hydrops fetalis in this case of Hennekam lymphangiectasia‐lymphedema syndrome‐1. WES is a useful approach for diagnosing rare single‐gene conditions with nonspecific phenotypes and should be considered early in the diagnostic process of investigating fetal abnormalities.