bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interferometric Water Level Tilt Meter Development in Finland and Comparison with Combined Earth Tide and Ocean Loading Models
Authors: Ruotsalainen Hannu 
Published: August 2018

Abstract
A modern third-generation interferometric water level tilt meter was developed at the Finnish Geodetic Institute in 2000. The tilt meter has absolute scale and can do high-precision tilt measurements on earth tides, ocean tide loading and atmospheric loading. Additionally, it can be applied in various kinds of geodynamic and geophysical research. The principles and results of the historical 100-year-old Michelson–Gale tilt meter, as well as the development of interferometric water tube tilt meters of the Finnish Geodetic Institute, Finland, are reviewed. Modern Earth tide model tilt combined with Schwiderski ocean tide loading model explains the uncertainty in historical tilt observations by Michelson and Gale. Earth tide tilt observations in Lohja2 geodynamic station, southern Finland, are compared with the combined model earth tide and four ocean tide loading models. The observed diurnal and semidiurnal harmonic constituents do not fit well with combined models. The reason could be a result of the improper harmonic modelling of the Baltic Sea tides in those models.
Einstein-AdS action, renormalized volume/area and holographic Rényi entropies
Authors: Anastasiou Giorgos , Araya Ignacio J. , Arias Cesar , Olea Rodrigo 
Published: August 2018

AbstractWe exhibit the equivalence between the renormalized volume of asymptotically anti-de Sitter (AAdS) Einstein manifolds in four and six dimensions, and their renormalized Euclidean bulk gravity actions. The action is that of Einstein gravity, where the renormalization is achieved through the addition of a single topological term. We generalize this equivalence, proposing an explicit form for the renormalized volume of higher even-dimensional AAdS Einstein manifolds. We also show that evaluating the renormalized bulk gravity action on the conically singular manifold of the replica trick results in an action principle that corresponds to the renormalized volume of the regular part of the bulk, plus the renormalized area of a codimension-2 cosmic brane whose tension is related to the replica index. Renormalized Rényi entropy of odd-dimensional holographic CFTs can thus be obtained from the renormalized area of the brane with finite tension, including the effects of its backreaction on the bulk geometry. The area computation corresponds to an extremization problem for an enclosing surface that extends to the AdS boundary, where the newly defined renormalized volume is considered.
More than Moore’s Mores: Computers, Genomics, and the Embrace of Innovation
Authors: November Joseph 
Published: August 2018

AbstractThe genomics community has frequently compared advances in sequencing to advances in microelectronics. Lately there have been many claims, including by the National Human Genome Research Institute (NHGRI), that genomics is outpacing developments in computing as measured by Moore's law – the notion that computers double in processing capability per dollar spent every 18-24 months. Celebrations of the “$1000 genome” and other speed-related sequencing milestones might be dismissed as a distraction from genomics' slowness in delivering clinical breakthroughs, but the fact that such celebrations have been persistently encouraged by the NHGRI reveals a great deal about the priorities and expectations of the American general public, the intended audience of the genomics–computing comparison. By delving into the history of speculative thinking about sequencing and computing, this article demonstrates just how much more receptive to high-risk/high-payoff ventures the NIH and the general public have become. The article also provides access to some of the roots and consequences of the association of “innovation talk” with genomics, and the means to look past that association to the less glamorous (but arguably much more important) contributions of the NHGRI to building the field of genomics.
The Favorable Effect of Empagliflozin on Erectile Function in an Experimental Model of Type 2 Diabetes
Authors: Assaly Rana , Gorny Diane , Compagnie Sandrine , Mayoux Eric , Bernabe Jacques , Alexandre Laurent , Giuliano François , Behr-Roussel Delphine 
Published: August 2018

Abstract

Introduction
Following the results of the EMPA-REG Outcome trial, we hypothesized that empagliflozin, a highly potent and specific sodium/glucose cotransporteur 2 inhibitor, could improve type 2 diabetes mellitus (T2DM)-associated erectile dysfunction (ED), a highly prevalent complication of T2DM, very often coexisting with cardiovascular complications and considered as a prognostic factor of cardiovascular disease in men with diabetes.

Aim
To investigate the effects of chronic treatment with empagliflozin on ED in a T2DM rat model in the presence or absence of sildenafil.

Methods
Male Goto-Kakizaki (GK), a model of T2DM, and age-matched Wistar rats received placebo or empagliflozin treatment at 25.3 ± 0.9 mg/kg/d for 4 weeks. Then, the in vivo effect of empagliflozin on erectile function was assessed by electrical stimulation of the cavernous nerve at different frequencies under anesthesia in the presence or absence of acute intravenous injection of sildenafil. Endothelium-dependent, -independent, and nitrergic relaxations of cavernosal strips from the rats were studied.

Main Outcome Measures
Body weight, food consumption, metabolic parameters, plasma inflammation biomarkers, and in vivo erectile responses elicited by electrical stimulation of the cavernous nerve in empagliflozin-treated and untreated GK rats and control Wistar rats were assessed and followed by concentration or frequency response curves to endothelium-dependent, -independent, and nitrergic relaxations of cavernosal strips from these rats.

Results
Chronic empagliflozin followed by acute sildenafil significantly improved erectile responses in adult GK rats (n = 12–15/group). Ratios of intracavernous pressure and area under the curve/mean arterial pressure during the electrical stimulation were significantly increased in empagliflozin-treated vs untreated GK rats. Nitrergic relaxations of cavernosal strips from GK rats were significantly increased with empagliflozin compared with placebo. Moreover, the effect of sildenafil on erectile function was not altered by empagliflozin treatment.

Clinical Implications
Empagliflozin may benefit T2DM patient with ED.

Strengths & Limitations
The mechanism(s) by which empagliflozin shows favorable effect on erectile function in GK rats needs to be further elucidated.

Conclusion
Empagliflozin shows favorable effect on erectile function in diabetic GK rats mediated by an improvement of nitrergic relaxation of erectile tissue. Whether this favorable effect on ED in the experimental context of T2DM is due to better glycemic control or to another effect of empagliflozin deserves further investigation.
Bacterial communities of cryoconite holes of a temperate alpine glacier show both seasonal trends and year-to-year variability
Authors: Pittino Francesca , Maglio Maurizio , Gandolfi Isabella , Azzoni Roberto Sergio , Diolaiuti Guglielmina , Ambrosini Roberto , Franzetti Andrea 
Published: August 2018

ABSTRACTCryoconite holes are small depressions of the glacier surface filled with melting water and with a wind-blown debris on the bottom. These environments are considered hot spots of biodiversity and biological activities on glaciers and host communities dominated by bacteria. Most of the studies on cryoconite holes assume that their communities are stable. However, evidence of seasonal variation in cryoconite hole ecological communities exists. We investigated the variation of the bacterial communities of cryoconite holes of Forni Glacier (Central Italian Alps) during the melting seasons (July–September) 2013 and 2016, for which samples at three and five time-points, respectively were available. Bacterial communities were characterized by high-throughput Illumina sequencing of the hypervariable V5−V6 regions of 16S rRNA gene, while meteorological data were obtained by an automatic weather station. We found consistent trends in bacterial communities, which shifted from cyanobacteria-dominated communities in July to communities dominated by heterotrophic orders in late August and September. Temperature seems also to affect seasonal dynamics of communities. We also compared bacterial communities at the beginning of the melting season across 4 years (2012, 2013, 2015 and 2016) and found significant year-to-year variability. Cryoconite hole communities on temperate glaciers are therefore not temporally stable.
The linear instability of the stratified plane Couette flow
Authors: Facchini Giulio , Favier Benjamin , Le Gal Patrice , Wang Meng , Le Bars Michael 
Published: August 2018

We present the stability analysis of a plane Couette flow which is stably stratified in the vertical direction orthogonal to the horizontal shear. Interest in such a flow comes from geophysical and astrophysical applications where background shear and vertical stable stratification commonly coexist. We perform the linear stability analysis of the flow in a domain which is periodic in the streamwise and vertical directions and confined in the cross-stream direction. The stability diagram is constructed as a function of the Reynolds number$Re$and the Froude number$Fr$, which compares the importance of shear and stratification. We find that the flow becomes unstable when shear and stratification are of the same order (i.e. $Fr\sim 1$) and above a moderate value of the Reynolds number$Re\gtrsim 700$. The instability results from a wave resonance mechanism already known in the context of channel flows – for instance, unstratified plane Couette flow in the shallow-water approximation. The result is confirmed by fully nonlinear direct numerical simulations and, to the best of our knowledge, constitutes the first evidence of linear instability in a vertically stratified plane Couette flow. We also report the study of a laboratory flow generated by a transparent belt entrained by two vertical cylinders and immersed in a tank filled with salty water, linearly stratified in density. We observe the emergence of a robust spatio-temporal pattern close to the threshold values of$Fr$and$Re$indicated by linear analysis, and explore the accessible part of the stability diagram. With the support of numerical simulations we conclude that the observed pattern is a signature of the same instability predicted by the linear theory, although slightly modified due to streamwise confinement.
WHAT WE DON'T SEE WHEN WE SEE COPYRIGHT AS PROPERTY
Authors: Litman Jessica 
Published: August 2018

AbstractFor all of the rhetoric about the central place of authors in the copyright scheme, our copyright laws in fact give them little power and less money. Intermediaries own the copyrights, and are able to structure licenses so as to maximise their own revenue while shrinking their pay-outs to authors. Copyright scholars have tended to treat this point superficially, because – as lawyers – we take for granted that copyrights are property; property rights are freely alienable; and the grantee of a property right stands in the shoes of the original holder. I compare the 1710 Statute of Anne, which created statutory copyrights and consolidated them in the hands of publishers and printers, with the 1887 Dawes Act, which served a crucial function in the American divestment of Indian land. I draw from the stories of the two laws the same moral: Constituting something as a freely alienable property right will almost always lead to results mirroring or exacerbating disparities in wealth and bargaining power. The legal dogma surrounding property rights makes it easy for us not to notice.
EVIDENCE REQUIRED BY HEALTH TECHNOLOGY ASSESSMENT AND REIMBURSEMENT BODIES EVALUATING DIAGNOSTIC OR PROGNOSTIC ALGORITHMS THAT INCLUDE OMICS DATA
Authors: Barna Alexandre , Cruz-Sanchez Teresita M , Brigham Karen Berg , Thuong Cong-Tri , Kristensen Finn Boerlum , Durand-Zaleski Isabelle 
Published: August 2018

Objectives:Multi-analyte assays with algorithmic analyses (MAAAs) use combinations of circulating and clinical markers including omics-based sources for diagnostic and/or prognostic purposes. Assessing MAAAs is challenging under existing health technology assessment (HTA) methods or practices. We undertook a scoping review to explore the HTA methods used for MAAAs to identify the criteria used for clinical research and reimbursement purposes.Methods:This review included only non-companion (stand-alone) tests that are actionable and that have been evaluated by leading HTA or insurer/reimbursement bodies up to September 2017.Results:Twenty-five reports and articles evaluating seventeen MAAAs were examined, most of which have been developed in oncology. The two main models used were the EUnetHTA Core model and the Evaluation of Genomic Applications in Practice and Prevention ACCE framework. Clinical validity and utility criteria were used, as were economic, ethical, legal, and social aspects. Economic evidence on MAAAs was scarce, and there is no consensus on whether the perspectives used are sufficiently broad to include all relevant stakeholders.Conclusions:Clinical utility and efficiency were the most used criteria, with stronger evidence needed linking the use of the algorithm with the clinical outcomes in real-life practice. HTA bodies must as well consider questions related to the analytical validity of MAAAs or with organizational aspects. The two main models, the EUnetHTA Core model and the ACCE framework, could be adapted to the assessment of MAAAs.
Magnetospheric Source Region of Auroral Finger‐like Structures Observed by the RBSP‐A Satellite
Authors: Nishi Katsuki , Shiokawa Kazuo , Spence Harlan 
Published: August 2018

AbstractAuroral finger‐like structures appear equatorward of the auroral oval in the diffuse auroral region and contribute to the auroral fragmentation into patches. A previous report of the first conjugate observation of auroral finger‐like structures using a Time History of Events and Macroscale Interactions during Substorms (THEMIS) Ground‐Based Observatories camera and the THEMIS‐E satellite at a radial distance of ∼8 RE showed antiphase oscillations of magnetic and plasma pressures in the dawnside plasma sheet. In the present study, we report another simultaneous observation of auroral finger‐like structures at Gillam, Canada, at ∼0900 UT (0230 magnetic local time) on 14 November 2014 with the Radiation Belt Storm Probes satellites at 5.8 RE in the inner magnetosphere. From this simultaneous observation event, we obtained the following observations. (1) Auroral finger‐like structures developed poleward in the equatorward moving auroral arc at the equatorward edge of the auroral oval. (2) Both the electron and ion OMNI fluxes measured by HOPE increased at ∼0900 UT as the satellite footprint entered the auroral region, indicating that the satellite was crossing the observed auroral finger‐like structures. (3) The absolute value of magnetic pressure was several times that of the plasma pressure, and no systematic phase relationship was identified between the magnetic and plasma pressures, unlike that in the THEMIS case. Based on these observations, we discuss two possible causes of the observed finger‐like structures, namely, pressure‐driven instability in the magnetosphere and gradient drift instability in the ionosphere. In this paper, the latter possibility is newly suggested to develop in the equatorward moving aurora associated with the westward electric field in the equatorward ionospheric density gradient.
Evolution and Distribution of the Early Aftershocks Following the 2008 Mw 7.9 Wenchuan Earthquake in Sichuan, China
Authors: Yin Xin Zhong , Chen Jiu Hui , Peng Zhigang , Meng Xiaofeng , Liu Qi Yuan , Guo Biao , Li Shun Cheng 
Published: August 2018

AbstractUsing seismic data recorded by a dense temporary seismic array, we apply a waveform matched‐filter technique and obtain an early aftershock catalog around the mainshock rupture zone of the 2008 Wenchuan, Sichuan, China, earthquake. Specifically, we use 1,273 events in a relocated aftershock catalog as templates and scan through the waveforms within 7 days following the mainshock. We obtain up to ∼5.3 and ∼10 times more aftershocks than the standard and relocated catalogs, respectively. We find that early aftershocks mostly occurred below 10 km depth, downdip to large coseismic slip areas. Early aftershocks also show minor along‐strike migration with time since the mainshock, indicating triggering of afterslip following the mainshock. From the epicentral region to Beichuan where the mainshock slip was primarily reverse faulting, early aftershocks illustrated the Yingxiu‐Beichuan and Guanxian‐Jiangyou faults as high‐angle listric feature and rooted to a gentle dipping plane at the depth of ∼20 km. The aftershocks in the northeast segment of the Longmen Shan faults mostly occurred along a near‐vertical dipping fault, consistent with the primary strike‐slip component of mainshock slip in this region. In addition, differences in early and long‐term aftershock distribution indicate significant postseismic deformation along the conjugate Xiaoyudong fault. Our results help to illuminate the deep geometry of the Longmen Shan fault zone and the early evolution after the Wenchuan mainshock, which provides additional constraints to the mechanism of plateau uplifting.
Reassessing the Thermal Structure of Oceanic Lithosphere With Revised Global Inventories of Basement Depths and Heat Flow Measurements
Authors: Richards F. D. , Hoggard M. J. , Cowton L. R. , White N. J. 
Published: August 2018

AbstractHalf‐space cooling and plate models of varying complexity have been proposed to account for changes in basement depth and heat flow as a function of lithospheric age in the oceanic realm. Here, we revisit this well‐known problem by exploiting a revised and augmented database of 2,028 measurements of depth to oceanic basement, corrected for sedimentary loading and variable crustal thickness, and 3,597 corrected heat flow measurements. Joint inverse modeling of both databases shows that the half‐space cooling model yields a mid‐oceanic axial temperature that is >100°C hotter than permitted by petrologic constraints. It also fails to produce the observed flattening at old ages. Then, we investigate a suite of increasingly complex plate models and conclude that the optimal model requires incorporation of experimentally determined temperature‐ and pressure‐dependent conductivity, expansivity, and specific heat capacity, as well as a low‐conductivity crustal layer. This revised model has a mantle potential temperature of 1300 ± 50°C, which honors independent geochemical constraints and has an initial ridge depth of 2.6 ± 0.3 km with a plate thickness of 135 ± 30 km. It predicts that the maximum depth of intraplate earthquakes is bounded by the 700°C isothermal contour, consistent with laboratory creep experiments on olivine aggregates. Estimates of the lithosphere‐asthenosphere boundary derived from studies of azimuthal anisotropy coincide with the 1175 ± 50°C isotherm. The model can be used to isolate residual depth and gravity anomalies generated by flexural and sub‐plate convective processes.
Revisiting the Paleomagnetic Reversal Test: A Bayesian Hypothesis Testing Framework for a Common Mean Direction
Authors: Heslop D. , Roberts A. P. 
Published: August 2018

AbstractFor over 60 years a suite of field tests has provided paleomagnetists with a means to evaluate the timing of magnetic remanence acquisition and subsequent remanence stability. These tests are crucial for detecting potential overprinting by secondary remanences and for assessing the fidelity of the geological information carried by paleomagnetic signals. The reversal test was developed to detect secondary remanent magnetizations that could potentially bias paleomagnetic reconstructions. More recently, the reversal test has been applied to a broader set of problems, which require statistical assessment of common or antipodal paleomagnetic directions. From a statistical standpoint, the reversal test must distinguish whether two sets of paleomagnetic directions originate from populations with a common mean. However, earlier work has demonstrated that the reversal test may be ambiguous for small numbers of observations because insufficient information is available to reject the null hypothesis of a common mean direction. Here we develop a Bayesian framework to estimate directly the probability that two Fisher‐distributed sets of directions originate from populations with a common mean. This framework can be used to consider data sets with common or different precisions and, thus, provides a fully probabilistic version of the parametric reversal test. Additionally, adoption of a Bayesian framework means that ambiguity associated with the lack of information provided by small numbers of observations is incorporated into the final probability estimate in a natural way. Our new Bayesian test is demonstrated with numerical examples and case studies.
Seaglider Surveys at Ocean Station Papa: Oxygen Kinematics and Upper‐Ocean Metabolism
Authors: Pelland Noel A. , Eriksen Charles C. , Emerson Steven R. , Cronin Meghan F. 
Published: August 2018

AbstractUnderstanding variability in annual net community production (NCP) and factors affecting its estimation are important priorities for the study of ocean biogeochemistry. The time evolution of dissolved oxygen is useful proxy for NCP if the physical tendency can be isolated and removed; a key challenge is the resolution of the terms contributing to this tendency. Here oxygen balances are examined in the upper 200 m at Ocean Station Papa (50°N, 145°W) using data from Seaglider surveys June 2008 to January 2010. Sampling of horizontal gradients of oxygen, temperature, and salinity during these surveys allows the inference of monthly three‐dimensional advection and turbulent diffusion of oxygen. The resulting monthly oxygen balances show strong variability with depth, with similarities to the temperature balances shallower than 100 m and salinity balances deeper. The estimated annual NCP of 2.2 ± 1.2 mol C·m−2·year−1 in the top 120 m is in agreement with contemporary studies in the subarctic North Pacific Ocean. Horizontal advection in the surface layer is found to be small as previously assumed but important at greater depths: Assuming zero horizontal advection in the top 120 m would have resulted in an overestimate of annual NCP by 50%. Horizontal and vertical advection together dominated the oxygen balance in the permanent pycnocline. Results emphasize the three‐dimensional nature of the oxygen balance, even in this relatively quiescent location, and further demonstrate the viability of autonomous spatial surveys for resolving physical oxygen transport terms.