bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristic of Pulse Displacement in Cementation of Vertical Well Washout
Authors: Zhang Zhuangzhuang , Huang Zhongwei , Li Shuailin , Li Gensheng 
Published: November 2024

Abstract
Displacement of residual fluid at the corners of washout is a problem during primary cementation. This is due to the nature of flow which will form favor flowing path in the displacement. In this paper, we propose a pulse displacement method in which injecting velocity changes with time according to specific functions. The purpose is to break the prior flowing path and increase the performance of displacement. Firstly, we investigate the difference between pulse displacement and constant velocity cementing. Then, we illustrate the influences of velocity function and washout geometry on pulse displacement performance. Results show that pulse displacement is of advantage in primary cementing of washout. Generally, pulse displacement induces strong and stable circular flow near the entrance of washout assisting sweeping displaced fluid. This circular flow becomes negligible when travels around 20 cm from the washout inlet when average velocity (vo) is 1 m/s in this paper. However, the performance is similar for both pulse displacement and constant cementing at location far from the entrance. Furtherly, the parametric analysis shows that the displacement efficiency (DE) reduces with rising of average velocity and there is optimal value of velocity frequency (f) and amplitude (a) to have the best displacing performance. Also, combination with high value of f, vo and a is benefit, but this will induce strong pressure vibration which may lead to downhole problem. Elongation of washout is of advantage for the displacement, but the enlargement of washout diameter has negative effect.
Comprehensive Usages of Multi Detector Pulsed Neutron Logging Tools to Overcome Mature Field's Challenges: Case Study from ACG Field
Authors: Ramazanov Rizvan , Han Xiaogang , Zett Adrian , Atakishiyev Fuad 
Published: November 2024

Abstract
Effective reservoir management of mature fields hinges on sustaining production. In most cases, the reservoir conditions differ from the initial measurement at virgin environment. The Azeri-Chirag-Gunashli (ACG) field, a substantial asset located in the Caspian Sea, Azerbaijan, has been developed over more than two decades. With the development of the field, production of reservoir has gradually shifted from Fasila thick uniform sand bodies to Balakhany heterogenous formation. Understanding the changes in the reservoir caused by down flank water and crestal gas injection is pivotal for the success of reservoir development.
Addressing contemporary petrophysical surveillance challenges, Multi Detector Pulsed Neutron (MDPN) technology emerges as a key solution for saturation measurement through casing or surveillance in complex logging scenarios. Challenges may stem from uncertainty of formation water salinity, complex logging environments, complexity of formation lithology, etc. Historically, MDPN is mainly used to measure hydrocarbon saturations by utilizing petrophysical measurements such as formation sigma, C/O, etc. MDPN also furnishes crucial data on well integrity. For instance, open hole gravel pack, a prevalent completion in ACG to prevent the problem of sand production. An innovative pack quality surveillance has been developed, benefiting from pulsed neutron logging technology.
This paper describes the workflow developed for matured field independent of service providers and presents real-world instances of measuring hydrocarbon saturation behind casing. Challenges of using pulsed neutron logging tools in complex logging conditions, such as saturation in open hole gravel pack completion, logging through multiple tubulars, formation lithology effects are also demonstrated and discussed. While saturation garners more attention, well integrity is another main usage of pulsed neutron logging tool, which unfortunately is less explored when compared to saturation. In ACG, Pulsed neutron logging tool is also widely used for Gravel Pack Evaluation (GPE), water flow detection behind casing. Combining reservoir and well integrity surveillance is an efficient way of logging for comprehensive interpretation to address reservoir management and well health diagnostic applications. Logging program optimization can significantly reduce operation cost and maximize the value of MDPN logs. For instance, extracting the baseline saturation logs from GPE surveillance and pack information at high logging speed are also demonstrated in this paper.
Evaluation of Nondamaging Sand Control Method for Reducing Sand Production at the Caspian Depression Field
Authors: Zeinula Aizhan , Abdrazakov Dmitriy , Asanov Karim , Kruglov Ruslan , Kaziyev Danabek 
Published: November 2024

Abstract
This paper describes laboratory and analytical work conducted to evaluate the potential effectiveness of a new formation particle conglomeration technology. The technology is based on pumping a special fluid solution that increases the attraction of reservoir sand particles without using damaging resins, aiming to reduce sand production and enhance well productivity in the formations of the V. Moldabek section at the Kenbay field.
Laboratory studies were performed to test the compatibility and efficiency of the new sand- conglomerating fluid, as well as to assess its application risks. Experiments involved core samples with varying permeability and clay mineral content. Research methods included linear swelling measurements and filtration studies to evaluate the impact on reservoir permeability during the proposed fluid injection. Additionally, the chemical composition of the proposed solution was optimized specifically for the Caspian region to ensure maximum effectiveness.
The application of the new solution in laboratory conditions demonstrated a greater than 70% reduction in sand production and significant improvement in well productivity. Notably, the permeability reduction observed in samples with high clay mineral content was manageable with further optimization. The technology showed promising results with minimal permeability loss in most samples (less than 40%), suggesting its potential to markedly improve extraction efficiency. While some risks of formation fractures were identified, these were planned to be mitigated through controlled injection rates. The findings indicate that the proposed technology can enhance well productivity and profitability by eliminating standby periods for cleaning the wells and replacing costly workover jobs with simple, short injection treatments.
Therapeutic trajectories of families with rare diseases in Chile from the perspectives of patients, carers, and healthcare workers: a qualitative study
Authors: Cabieses Báltica , Obach Alexandra , Roberts Antonia , Repetto Gabriela 
Published: November 2024

Abstract

Background
Rare diseases are conditions that have a low prevalence in the population and a high disease burden and are often chronic and progressive. International evidence concerning the experience of people and families living with rare diseases is scarce, leading to late and erroneous diagnoses, as well as non-specific treatments. This study explored the therapeutic trajectories of people and families living with rare diseases within Chile's public and private healthcare systems from the perspective of patients, caregivers, and medical teams, including the initial symptoms, first consultation, testing, diagnosis, treatment, and follow-up.
Methods
A qualitative exploratory study was conducted through multiple case studies. Sixty participants were interviewed in person and/or virtually: patients (n = 16), caregivers (n = 22), healthcare workers (n = 20), and two patient organisation leaders. The material was analysed using thematic analysis. The project was approved by the Scientific Ethics Committee of Facultad de Medicina Clínica Alemana, Universidad del Desarrollo.
Results
After similar initial symptoms and first consultation, three main types of trajectories were identified: (i) the path taken by those who reach a diagnosis for a disease that has specific treatment available; (ii) the journey of those who reach a diagnosis for their health condition, but their disease does not have a specific treatment available; and (iii) the trajectory of those who have not reached a diagnosis and receive symptomatic treatments for symptoms.
Conclusions
The therapeutic trajectories of patients with rare symptoms are similar in terms of initial symptoms and first consultation. However, their paths diverge at the diagnostic stage, with diverse experiences related to these journeys, largely based on having a diagnosis and whether there is a specific treatment. Rare conditions in Chile requires further attention and urgent action that considers those who live with them and their families.
Evaluation of bioactive compounds, radical scavenging activity and sensory quality attributes of tropical fruit juice blends
Authors: Gomez Saji , S Ananya P , Sadi Rinsa , Raphael Rixon , Kuruvila Bintu 
Published: November 2024

Abstract

Fruit juice blends encompass the flavour and nutritional properties of the fruits used for their preparation, which give them distinct and unique phytochemical composition and flavour attributes. This research was carried out to evaluate the effect of blending tropical fruits such as mango (Mangifera indica), acerola (Malpighia punicifolia), cashew apple (Anacardium occidentale), guava (Psidium guajava) and Indian gooseberry (Emblica officinalis) on their sensory properties as well as the level of bioactive compounds, ultimately leading to their antioxidant potential. The blended beverage was pasteurized, followed by storage at 5 20C for three months. Results revealed that the highest overall acceptability score was recorded for the blend containing mango and acerola (8.0). Even after three months of storage, the blend containing mango and acerola had significantly higher ascorbic acid (159.490 mg100g-1), which was almost six times higher than the one blended with Indian gooseberry. The combination of mango and cashew apple had the highest initial total carotenoids (1.4628 mg100g-1), followed by the one containing mango and acerola (1.3162 mg100g-1). The blend of mango and Indian gooseberry had the highest total phenolics (315.0 mg100g-1). The blend of mango in combination with Indian gooseberry and acerola exhibited highest DPPH scavenging activity of 2.743 µgml-1 and 2.845 µgml-1, respectively. The findings suggest that the tropical fruits mentioned above are valuable sources of functional nutrients in addition to their unique and diverse flavour attributes.
Photorefractive and pyroelectric photonic memory and long-term stability in thin- film lithium niobate microresonators
Authors: Ren Xinyi , Lee Chun-Ho , Xue Kaiwen , Ou Shaoyuan , Yu Yue , Chen Zaijun , Yu Mengjie 
Published: November 2024

Abstract

The stability of the integrated photonic circuits is of critical importance for many applications that require high frequency precision or robust operation over time, such as optomechanical sensing, frequency conversion, optical communication, and quantum optics. Photonic memory is useful for low-energy optical computing and interconnects. Thin film lithium niobate (TFLN), as an emerging photonic platform, exhibits complex material properties including pyroelectric (PE) and photorefractive (PR) effects which could lead to intra-device drift and excess noise under different environmental or operating conditions as well as be utilized for building photonic memory. However, the long-term stability and memory effect of its optical properties has not been explored. In this paper, we discovered a long-lived change of optical refractive index as a result of light excitation and temporal temperature variation using Z-cut TFLN microresonators and reveal a strong dependence of the instability with the crystal orientation of the thin film form. The recovery time are measured to be over 10 hours. Leveraging the photonic memory with a long relaxation time, we realize optical trimming of the cavity resonance frequencies. Our result offers insights towards understanding the fundamental noise properties and dynamic behavior of the integrated TFLN material and devices.
A comparative study of the effectivity of MSC-based, NP-based and combined therapies in an experimental model of NaIO3-induced retinal degeneration
Authors: Palacka Katerina , Hermankova Barbora , Cervena Tereza , Rossner Pavel , Holan Vladimir , Javorkova Eliska 
Published: November 2024

Abstract

Background Mesenchymal stem cells (MSCs) are currently being tested as one of the promising options for retinal therapy, due to their immunomodulatory and neuroprotective abilities. Although the potential of MSCs in ophthalmology has been well documented, there are several limitations associated with this type of treatment. One complication may be the increased immune reaction following intravitreal application. Therefore, combinations of MSCs with other therapeutic agents are now being considered. One such approach is represented by the application of MSCs with nanoparticles (NPs), which are widely used in medicine for their antimicrobial and immunomodulatory properties. The combination of both therapies could provide an increase in immunoregulatory and neuroprotective effects. However, the interaction of MSCs with NPs in ophthalmological treatment should be further investigated.Methods In this study, we tested the in vitro and in vivo effect of silver (Ag) NPs on the properties of MSCs in an experimental mouse model of chronic retinal degeneration induced by sodium iodate.Results The results showed that simultaneous intravitreal administration of MSCs with AgNPs had no effect on the survival of MSCs in the eye, but a less effective regulation of Iba-1 (activated microglia/macrophages) and interleukin-1β expression in the retinal tissue compared to MSC or AgNP only treated groups was observed. Nevertheless, all treated groups had decreased expression of the gene for galectin-3 compared to the untreated control. In addition, MSCs applied alone or in combination with AgNPs and sorted from the degenerated retina on day 7 after application had increased expression of genes for specific retinal markers, and for transforming growth factor-β and insulin-like growth factor-1 compared to untreated naïve MSCs. On the contrary, the increased expression of the gene for glial cell-derived growth factor was observed only in the MSCs combined with AgNPs. However, the application of MSCs with AgNPs triggered increased expression of the IL-6 gene in the CD45 cells separated from the retina.Conclusion Overall, the results show that the application of MSCs or AgNPs has an immunomodulatory effect in chronic retinal degeneration, but the combined application of MSCs and AgNPs could decrease the effects of a single therapy.
Identifying targeted cell-free DNA methylation regions in head and neck cancer via paired methylome analysis
Authors: Li Tingyi , Patel Krupal B. , Yu Xiaoqing , Yao Sijie , Wang Liang , Chung Christine H. , Wang Xuefeng 
Published: November 2024

Abstract

Despite the critical need, progress in developing cell-free DNA (cfDNA) liquid biopsy biomarkers for the diagnosis and risk stratification of head and neck squamous cell carcinoma (HNSC) has been limited. In this study, we present a comprehensive paired-sample differential methylation region (psDMR) analysis in HNSC, aimed at identifying reliable and HNSC-specific regions for cfDNA biomarker discovery. Traditional DMR analyses often overlook paired-sample information and fail to account for the heterogeneity within HNSC tissues. Our findings reveal a substantial overlap of hypermethylated DMRs across two independent HNSC methylation datasets, demonstrating the robustness and clinical relevance of these regions for cfDNA biomarker development. Furthermore, we identified consistent DMRs in both HNSC and lung squamous cell carcinoma (LSCC), suggesting the potential for pan-squamous cell carcinoma biomarkers. Notably, gene clusters such as HOXD, ZNF, and NKX2 were frequently hypermethylated, providing new insights into the shared epigenetic landscape of HNSC and LSCC. This study underscores the importance of incorporating matched normal tissues in cancer methylome analyses and establishes a foundation for advancing cfDNA-based biomarker discovery across squamous cell carcinomas.
Characterization of the peripheral nervous system manifestations in patients with IgG4-related disease: a systematic review
Authors: Rosenstein Renan Fabri , Baima José Pedro , Giardini Henrique Ayres Mayrink , Mendonça Leonardo Oliveira , Silva Guilherme Diogo 
Published: November 2024

Abstract

Background: Immunoglobulin G4-related disease (IgG4-RD) is a multisystem fibroinflammatory condition. While neurological involvement typically presents as pachymeningitis, there have been reports of peripheral nervous system (PNS) manifestations in IgG4-RD patients. Our objective was to review the involvement of the peripheral nerves, neuromuscular junction, and muscles in individuals with IgG4-RD.
Main text: We conducted a systematic review of case reports and case series of patients with IgG4-related disease (IgG4-RD) presenting with peripheral nervous system (PNS) manifestations, using the PubMed/MEDLINE, Embase, and Scopus databases. Articles were analyzed for demographic characteristics, neurological presentations, systemic involvement, and investigative findings (laboratory, electrophysiological, and pathological). A total of 38 articles, encompassing 42 cases of PNS manifestations in patients with IgG4-RD, were included. Peripheral nerve involvement was most frequently reported (25/42, 60%). The most common clinical presentations were mononeuritis multiplex (48%) and polyneuropathy (20%). Systemic involvement was observed in all patients with peripheral neuropathy. Electrodiagnostic studies revealed an axonal pattern in 88% of cases, while nerve biopsies were compatible with vessel and nerve infiltration by IgG4-positive cells in 46% (6/13) of cases. Involvement of the neuromuscular junction was infrequently reported (n = 4), presenting as Lambert-Eaton syndrome (25%) or myasthenia gravis (75%), with all cases being negative for anti-acetylcholinesterase antibodies. Muscle involvement (n = 13) manifested as focal myositis in 53% and a limb-girdle muscle weakness pattern in 47%. Systemic involvement was absent in 61% of muscle cases. Creatine kinase levels were elevated in 53%, and muscle biopsy demonstrated IgG4-positive cell infiltration in all focal myositis cases.
Conclusion: Our review suggests that typical PNS manifestations in patients with IgG4-RD include mononeuritis multiplex, polyneuropathy, and focal myopathy. However, comorbid conditions such as systemic vasculitis, anti-acetylcholinesterase antibody-negative myasthenia gravis, and inflammatory myositis should also be considered as potential contributors to PNS symptoms.
Bibliometric analysis of frozen shoulder research in the last ten years
Authors: Jiang Yongdong , Kanglin Li , Shihua Gao , Yufeng Wu 
Published: November 2024

Abstract

Objective
To analyze the research status, hotspots, and development trends in the field of frozen shoulder in recent 10 years.
Methods
The literature included in the core collection of the Web of Science database from January 1, 2014 to December 31, 2023 was retrieved. VOSViewer and CiteSpace software were used to visually analyze the publication year, country/region, journal, institution, author, literature co-citation, and keyword co-occurrence of the literature.
Results
A total of 631 literatures were retrieved, and the number of publications entered a rapid growth stage in the past 5 years. South Korea, the United States and China are the three countries with the largest number of publications. Keimyung University in South Korea is the most prolific institution. The Journal Of Shoulder And Elbow Surgery is the most popular journal in the field, accounting for 7.92% of publications, as well as the most cited journal. Cho is the most active author with a total of 18 publications, while Millar is the author with the most citations per article. shoulder pain, ultrasound-guided, physiotherapy, etc. were the most commonly used keywords.
Conclusion
The literature on frozen shoulder research is increasing, but there is still a lack of cooperation among countries, institutions and authors. Pain management of frozen shoulder, ultrasound-guided nerve block therapy, physical therapy, and diabetes are among the hot topics. PRP treatment, Mendelian randomization studies and high-quality randomized controlled studies are the directions of future research.
Detection and Segmentation of Pulmonary Embolism in 3D CT Pulmonary Angiography Using a Threshold Adjustment Segmentation Network
Authors: Fan Jian-cong , luan Haoyang , Li Yang , qiao Yaqian , Ren Yande 
Published: November 2024

Abstract

Pulmonary embolism is a life-threatening condition where early diagnosis and precise localization are crucial for improving patient outcomes. While CT pulmonary angiography (CTPA) is the primary method for detecting pulmonary embolism, existing segmentation algorithms struggle to effectively distinguish thrombi from vascular structures in complex 3D CTPA images, often leading to both false positives and false negatives. To address these challenges, the Threshold Adjustment Segmentation Network (TSNet) is proposed to enhance segmentation performance in 3D CTPA images. TSNet incorporates two core modules: the Threshold Adjustment Module (TAD) and the Geometric-Topological Axial Feature Module (GT-AFM). TAD utilizes logarithmic scaling, adaptive adjustments, and nonlinear transformations to optimize the probability distributions of thrombi and vessels, reducing false positives while improving the sensitivity of thrombus detection. GT-AFM integrates geometric features and topological information to enhance the recognition of complex vascular and thrombotic structures, improving spatial feature processing. Experimental results show that TSNet achieves a sensitivity of 0.761 and a false positives per scan of 1.273 at ε = 0 mm. With an increased tolerance of ε = 5 mm, sensitivity improves to 0.878 and false positives per scan decreases to 0.515, significantly reducing false positives. These results indicate that TSNet demonstrates superior segmentation performance under various tolerance levels, showing robustness and a well-balanced trade-off between sensitivity and false positives, making it highly promising for clinical applications.