bluuebunny/crossref_metadata_2025_split huggingface dataset:
IDEA intervention to prevent depressive symptoms and promote well-being in early-stage dementia: protocol for a randomised controlled feasibility study
Authors: Tuijt Remco , Livingston Gill , Gould Rebecca L , Jones Rebecca , Verdaguer Elisabet Sole , Orgeta Vasiliki 
Published: September 2019

ObjectiveDepressive symptoms are common among people with dementia, impacting quality of life and cognitive and functional decline. Currently, little is known about the acceptability and feasibility of psychological interventions for people with mild dementia, with recent reviews identifying the need for further evidence. Developing and evaluating psychological interventions to prevent and treat these symptoms is, therefore, an important clinical and research priority. This protocol describes a study testing the acceptability and feasibility of a manual-based behavioural activation (BA) intervention for preventing and treating depressive symptoms in people with mild dementia. The aim of this study is to explore the feasibility of conducting a pragmatic multicentre randomised controlled trial of clinical effectiveness of an eight-session intervention. The Intervention to prevent Depressive symptoms and promote well-being in EArly-stage dementia (IDEA) programme supports people with dementia and their family carers in identifying and scheduling enjoyable and meaningful activities.Methods and analysisSixty people who have received a diagnosis of dementia of any type in the last 6 months will be recruited via memory clinics. Further criteria are a Mini-Mental State Examination score of ≥20, and a family carer who can assist with the intervention. Consenting participants will be randomised in a ratio of 2:1 to BA or to treatment as usual. Analyses will estimate parameters such as rates of recruitment, retention and number of sessions completed. Questionnaires measuring depressive symptoms and quality of life for both the person with dementia and their carer will be completed at baseline, 3 and 6 months. Qualitative interviews will explore acceptability of the intervention, study procedures and experiences of the sessions.Ethics and disseminationThis study received a favourable ethical opinion from the London Camberwell St Giles Research Ethics Committee (16/LO/0540). We will disseminate findings at key conferences, the Alzheimer’s Society and University College London websites and local stakeholder events.Trial registration numberISRCTN75503960; Pre-results.
Antiplatelet therapy for prevention of thromboembolic complications in coiling-only procedures for unruptured brain aneurysms
Authors: Almekhlafi Mohammed A , Al Sultan Abdulaziz S , Kuczynski Andrea M , Brinjikji Waleed , Menon Bijoy K , Hill Michael D , Goyal Mayank 
Published: September 2019

Background and purposeThromboembolic events are recognized complications of aneurysm coiling.ObjectiveTo identify any protective effects of antiplatelet therapy use before coiling of unruptured aneurysms.MethodsWe conducted a meta-analysis of clinical studies published up to February 2019. We included studies reporting symptomatic thromboembolic events (defined as clinical stroke or transient ischemic attacks) in patients who received antiplatelet therapy before coiling of unruptured aneurysms using unassisted coiling, balloon assistance, or multiple microcatheters. We excluded ruptured aneurysms and those treated with stent coiling or flow diverters.ResultsWe identified 14 studies (2486 patients). All were single-center studies and four were prospective. In three studies with a control (no treatment) arm, the pooled risk ratio for symptomatic thromboembolic events with versus without antiplatelet therapy was 0.33 (95% CI 0.17 to 0.92, p= 0.035). The cumulative risk of symptomatic thromboembolic events with single antiplatelet agents was 5.0% ‘56/1122’ (95% CI 1.6% to 8.4%, I283.63%), and with dual or multiple agents 2.7% ‘33/1237’ (95% CI 1.0% to 3.0%, I239.9%). The incidence of diffusion lesions was reported in seven studies. It was 50.5% ‘96/190’ (95% CI 7.3% to 93.9%, I294.4%) with single agents compared with 43.9% ‘196/446’ (95% CI 25.9% to 61.9%, I273.4%) with dual or multiple agents.ConclusionPeriprocedural antiplatelet therapy was associated with a low symptomatic thromboembolic event after coiling-only for unruptured aneurysms. However, available evidence is of limited quality with significant heterogeneity, requiring evidence from randomized controlled trials.
Earth observation applications for coastal sustainability: potential and challenges for implementation
Authors: Politi Eirini , Paterson Shona K. , Scarrott Rory , Tuohy Eimear , O’Mahony Cathal , Cámaro-García Walther C. A. 
Published: September 2019

Abstract
The coast is home to unique ecosystems, where complex ecological processes take place through the interaction of terrestrial, aquatic, atmospheric, and human landscapes. However, there are considerable knowledge and data gaps in achieving effective and future change-proof sustainable management of coastal zones around the world due to both technical and social barriers, as well as governance challenges. Currently, the role of Earth observation (EO) in addressing many of the recognised information gaps is small and under-utilised. While EO can provide much of the spatiotemporal information required for historical analysis and current status mapping, and offers the advantage of global coverage; its uptake can be limited by technical and methodological challenges associated mostly with lack of capacity and infrastructure, product accuracy and accessibility, costs, and institutional acceptance. While new initiatives and recent technological progress in the EO and information technology arena aim to tackle some of these issues so that EO products can be more easily used by non-EO experts, uptake is still limited. This paper discusses how EO can potentially inform transformative practices of planning in the coastal water zone, by using examples to demonstrate the EO potential in providing information relevant to decisionmaking framed by international agreements, such as the United Nations Agenda 2030, the Convention on Biological Diversity, and the Sendai Framework for Risk Reduction. By presenting evidence for how EO can contribute to innovative opportunities and data synergies at scale, the paper discusses opportunities and challenges for a more solution-led approach to sustainable coastal management.
Aronia juice consumption prior to half-marathon race can acutely affect platelet activation in recreational runners
Authors: Stevanović Vuk , Pantović Ana , Krga Irena , Zeković Milica , Šarac Ivana , Glibetić Maria , Vidović Nevena 
Published: September 2019

Long-distance running, especially in non-professional runners, can increase cardiac arrest risk by enhancing platelet activation and aggregation. Polyphenols can exert cardioprotective effects by positively influencing platelet function. This study aimed to examine the acute effects of polyphenol-rich aronia juice consumption, before simulation of a half-marathon race, on platelet activation and aggregation with leukocytes in recreational runners. In this acute crossover study,10 healthy male runners (age 30.8 ± 2.3 years) consumed breakfast with 200 mL of aronia juice or 200 mL of placebo. They warmed-up and ran a simulated half-marathon race (21.1 km). Blood was collected at baseline, and at 15 min, 1 h, and 24 h after the run. All variables were analyzed with 4 (time) × 2 (group) ANOVA with repeated measures on both factors. Results revealed a significant effect of group on platelet activation parameters: P-selectin and GPIIb-IIIa expressions significantly decreased in the aronia group compared with the placebo group (F[1,9] = 10.282, p = 0.011 and F[1,9] = 7.860, p = 0.021, respectively). The effect of time was significant on both platelet aggregation markers: platelet-monocyte and platelet-neutrophil aggregates were significantly lower after the race (F[3,7] = 4.227, p = 0.014 and F[3,7] = 70.065, p = 0.000, respectively), with changes more pronounced in the later. All effects remained when platelets were exposed to an agonist. These results suggest that aronia consumption could counteract the half-marathon race-induced changes in platelet function. Novelty Aronia juice consumption significantly decreased the expression of platelet activation markers but did not affect platelet aggregation. The race itself did significantly reduce platelet-neutrophil aggregation. Aronia juice may serve as a supplement beverage for recreational runners to alleviate enhanced platelet reactivity caused by prolonged running.
Quasi-cosmological traversable wormholes in f(R) gravity
Authors: Golchin Hanif , Mehdizadeh Mohammad Reza 
Published: September 2019

Abstract
In this paper, we study traversable wormholes in the context of f(R) gravity. Exact solutions of traversable wormholes are found by imposing the nonconstant Ricci scalar. These solutions asymptotically match spherical, flat and hyperbolic FRW metric. By choosing some static f(R) gravity models, we verify the standard energy conditions for the asymptotically spherical, flat and hyperbolic wormhole solutions. Unlike the Einstein gravity, we find that in the context of f(R) modified gravity, the asymptotically spherical, flat and hyperbolic wormhole solutions can respect the null energy condition (NEC) at the wormhole throat and near that. We find that in some static f(R) models, asymptotically flat and hyperbolic wormholes respect the weak energy condition (WEC) through the whole space.
Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses
Authors: Caetano Mauricio S. , Younes Ahmed I. , Barsoumian Hampartsoum B. , Quigley Michael , Menon Hari , Gao Chan , Spires Thomas , Reilly Timothy P. , Cadena Alexandra P. , Cushman Taylor R. , Schoenhals Jonathan E. , Li Ailin , Nguyen Quynh-Nhu , Cortez Maria Angelica , Welsh James W. 
Published: September 2019

AbstractPurpose:Radiotherapy (RT) traditionally has been used for local tumor control in the treatment of cancer. The recent discovery that radiotherapy can have anticancer effects on the immune system has led to recognition of its ability to sensitize the tumor microenvironment to immunotherapy. However, radiation can also prompt adverse immunosuppressive effects that block aspects of systemic response at other tumor sites. Our hypothesis was that inhibition of the MER proto-oncogene tyrosine kinase (MerTK) in combination with anti-programmed cell death-1 (α-PD1) checkpoint blockade will enhance immune-mediated responses to radiotherapy.Experimental Design:We tested the efficacy of this triple therapy (Radiation + α-PD1 + α-MerTK mAbs) in 129Sv/Ev mice with bilateral lung adenocarcinoma xenografts. Primary tumors were treated with stereotactic radiotherapy (36 Gy in 3 12-Gy fractions), and tumors were monitored for response.Results:The triple therapy significantly delayed abscopal tumor growth, improved survival rates, and reduced numbers of lung metastases. We further found that the triple therapy increased the activated CD8+ and NK cells populations measured by granzyme B expression with upregulation of CD8+CD103+ tissue-resident memory cells (TRM) within the abscopal tumor microenvironment relative to radiation only.Conclusions:The addition of α-PD1 + α-MerTK mAbs to radiotherapy could alter the cell death to be more immunogenic and generate adaptive immune response via increasing the retention of TRM cells in the tumor islets of the abscopal tumors which was proven to play a major role in survival of non-small cell lung cancer patients.
Benjamin Franklin’s Influence on Mussar Thought and Practice: a Chronicle of Misapprehension
Authors: Afsai Shai 
Published: September 2019

Abstract
Benjamin Franklin’s ideas and writings may be said to have had an impact on Jewish thought and practice. This influence occurred posthumously, primarily through his Autobiography and by way of Rabbi Menachem Mendel Lefin’s Sefer Cheshbon ha-Nefesh (Book of Spiritual Accounting, 1808), which introduced Franklin’s method for moral perfection to a Hebrew-reading Jewish audience. This historical development has confused Judaic scholars, and Franklin specialists have been largely oblivious to it. Remedying the record on this matter illustrates how even within the presumably insular world of Eastern European rabbinic Judaism—far from the deism of the trans-Atlantic Enlightenment—pre-Reform, pre-Conservative Jewish religion was affected by broader currents of thought.
Uncertainty in Net Surface Heat Flux due to Differences in Commonly Used Albedo Products
Authors: Hogikyan Allison , Cronin Meghan F. , Zhang Dongxiao , Kato Seiji 
Published: September 2019

AbstractThe ocean surface albedo is responsible for the distribution of solar (shortwave) radiant energy between the atmosphere and ocean and therefore is a key parameter in Earth’s surface energy budget. In situ ocean observations typically do not measure upward reflected solar radiation, which is necessary to compute net solar radiation into the ocean. Instead, the upward component is computed from the measured downward component using an albedo estimate. At two NOAA Ocean Climate Station buoy sites in the North Pacific, the International Satellite Cloud Climatology Project (ISCCP) monthly climatological albedo has been used, while for the NOAA Global Tropical Buoy Array a constant albedo is used. This constant albedo is also used in the Coupled Ocean–Atmosphere Response Experiment (COARE) bulk flux algorithm. This study considers the impacts of using the more recently available NASA Cloud and the Earth’s Radiant Energy System (CERES) albedo product for these ocean surface heat flux products. Differences between albedo estimates in global satellite products like these imply uncertainty in the net surface solar radiation heat flux estimates that locally exceed the target uncertainty of 1.0 W m−2 for the global mean, set by the Global Climate Observing System (GCOS) of the World Meteorological Organization (WMO). Albedo has large spatiotemporal variability on hourly, monthly, and interannual time scales. Biases in high-resolution SWnet (the difference between surface downwelling and upwelling shortwave radiation) can arise if the albedo diurnal cycle is unresolved. As a result, for periods when satellite albedo data are not available it is recommended that an hourly climatology be used when computing high-resolution net surface shortwave radiation.
Diurnal Effects of Regional Soil Moisture Anomalies on the Great Plains Low-Level Jet
Authors: Campbell Matthew A. , Ferguson Craig R. , Burrows D. Alex , Beauharnois Mark , Xia Geng , Bosart Lance F. 
Published: September 2019

AbstractThe Great Plains (GP) low-level jet (GPLLJ) contributes to GP warm season water resources (precipitation), wind resources, and severe weather outbreaks. Past research has shown that synoptic and local mesoscale physical mechanisms (Holton and Blackadar mechanisms) are required to explain GPLLJ variability. Although soil moisture–PBL interactions are central to local mechanistic theories, the diurnal effect of regional soil moisture anomalies on GPLLJ speed, northward penetration, and propensity for severe weather is not well known. In this study, two 31-member WRF-ARW stochastic kinetic energy backscatter scheme ensembles simulate a typical warm season GPLLJ case under CONUS-wide wet and dry soil moisture scenarios. In the GP (24°–48°N, 103°–90°W), ensemble mean differences in sensible heating and PBL height of 25–150 W m−2 and 100–700 m, respectively, at 2100 UTC (afternoon) culminate in GPLLJ 850-hPa wind speed differences of 1–4 m s−1 12 hours later (0900 UTC; early morning). Greater heat accumulation in the daytime PBL over dry soil impacts the east–west geopotential height gradient in the GP (synoptic conditions and Holton mechanism) resulting in a deeper thermal low in the northern GP, causing increases in the geostrophic wind. Enhanced daytime turbulent mixing over dry soil impacts the PBL structure (Blackadar mechanism), leading to increased ageostrophic wind. Overnight geostrophic and ageostrophic winds constructively interact, leading to a faster nocturnal GPLLJ over dry soil. Ensemble differences in CIN (~50–150 J kg−1) and CAPE (~500–1000 J kg−1) have implications for severe weather predictability.
Identification of molecular species of phosphatidylcholine hydroperoxides in native and copper-oxidized triglyceride-rich lipoproteins in humans
Authors: Shrestha Rojeet , Chen Zhen , Miura Yusuke , Yamamoto Yusuke , Sakurai Toshihiro , Chiba Hitoshi , Hui Shu-Ping 
Published: September 2019

Background Triglyceride-rich lipoproteins are considered to be independent predictors of atherosclerotic cardiovascular disease. The molecular basis of its atherogenicity is uncertain. Here, we aim to identify molecular species of phosphatidylcholine hydroperoxides (PCOOH) in triglyceride-rich lipoproteins. For comparison, copper-oxidized triglyceride-rich lipoproteins were investigated as well. Methods A fasting EDTA blood sample was collected from six healthy human volunteers to isolate two major triglyceride-rich lipoproteins fractions – very low-density lipoproteins (VLDL) and intermediate-density lipoproteins (IDL) using sequential ultracentrifugation. Triglyceride-rich lipoproteins and plasma samples were studied for PCOOH by liquid chromatography (LC) coupled with Orbitrap mass spectrometry. Results Twelve molecular species of PCOOH in triglyceride-rich lipoproteins and/or plasma were identified using the following criteria: (1) high-resolution mass spectrometry (MS) with mass accuracy within 5 ppm, (2) retention time in LC and (3) fragmentation pattern in MS2 and MS3. PC36:4-OOH was most often detected in VLDL, IDL and plasma. The ratio of total PCOOH to phosphatidylcholine progressively increased with the duration of oxidation in both VLDL and IDL. Conclusion This study demonstrated the presence of 12 molecular species of PCOOH in native triglyceride-rich lipoproteins. The frequent detection of PCOOH in triglyceride-rich lipoproteins provides a molecular basis of the atherogenicity of triglyceride-rich lipoproteins. PCOOH in triglyceride-rich lipoproteins might serve as a molecular basis of the atherogenicity of triglyceride-rich lipoproteins.
Prospective Memory Performance in Simulated Air Traffic Control
Authors: Wilson Micah K. , Strickland Luke , Farrell Simon , Visser Troy A. W. , Loft Shayne 
Published: September 2019

Objective To examine the effects of interruptions and retention interval on prospective memory for deferred tasks in simulated air traffic control. Background In many safety-critical environments, operators need to remember to perform a deferred task, which requires prospective memory. Laboratory experiments suggest that extended prospective memory retention intervals, and interruptions in those retention intervals, could impair prospective memory performance. Method Participants managed a simulated air traffic control sector. Participants were sometimes instructed to perform a deferred handoff task, requiring them to deviate from a routine procedure. We manipulated whether an interruption occurred during the prospective memory retention interval or not, the length of the retention interval (37–117 s), and the temporal proximity of the interruption to deferred task encoding and execution. We also measured performance on ongoing tasks. Results Increasing retention intervals (37–117 s) decreased the probability of remembering to perform the deferred task. Costs to ongoing conflict detection accuracy and routine handoff speed were observed when a prospective memory intention had to be maintained. Interruptions did not affect individuals’ speed or accuracy on the deferred task. Conclusion Longer retention intervals increase risk of prospective memory error and of ongoing task performance being impaired by cognitive load; however, prospective memory can be robust to effects of interruptions when the task environment provides cuing and offloading. Application To support operators in performing complex and dynamic tasks, prospective memory demands should be reduced, and the retention interval of deferred tasks should be kept as short as possible.
Homelessness and Mortality Among Persons With Tuberculosis in Texas, 2010-2017
Authors: Agarwal Saroochi , Nguyen Duc T. , Graviss Edward A. 
Published: September 2019

Objective: A disproportionate number of tuberculosis cases and tuberculosis deaths occur among persons experiencing homelessness in the United States. Our objective was to identify risks for homelessness and death during mycobacterial treatment among persons experiencing homelessness with tuberculosis in Texas. Methods: Using data from the Centers for Disease Control and Prevention’s TB Genotyping Information Management System, we evaluated data on demographic, laboratory, and clinical characteristics of persons experiencing homelessness in Texas during the year before tuberculosis diagnosis, from January 1, 2010, through December 31, 2017. Results: Of 10 130 new diagnoses of tuberculosis among persons living in Texas during the study period, 543 were reported as being homeless in the year before tuberculosis diagnosis. The odds of dying during treatment were 2.26 (95% confidence interval, 1.68-3.03) times higher among persons with tuberculosis experiencing homelessness than among persons with tuberculosis living in homes. Conclusions: Our findings indicate that persons experiencing homelessness bear an undue burden of tuberculosis mortality in Texas. The burden may be related to poorer health caused by poverty stressors, comorbidities, or lack of access to health care.
Route selection for a three-dimensional elevator using deep reinforcement learning
Authors: Hammoudeh Ahmad 
Published: September 2019

While the car of the conventional elevator system moves only vertically in one dimension (up and down), the car of the three-dimensional elevator system travels in three perpendicular dimensions. The elevator moves through a vertical shaft to a certain floor and then the elevator serves multiple passengers distributed among different rooms at that floor. The controller decides which route should be taken to serve the passengers. This article proposes the use of deep reinforcement learning to select a route for the three-dimensional elevator. Deep reinforcement learning method learns from experiencing a large number of scenarios generated using Monte Carlo simulation offline. Once trained, deep reinforcement learning can select the route online. Numerical experimentations are used to show the superiority of deep reinforcement learning in finding an optimum or near optimum-route instantaneously. Although deep reinforcement learning is closer to finding the optimum route than other methods, finding an optimum route is not always guaranteed. Deep reinforcement learning has some limitations that include the long training time and the difficulties in training the neural networks. Practical application:Multidimensional elevators have been of expanding interest to the elevator industry as well as to traffic analysis engineers. This article demonstrates that deep reinforcement learning surpasses other methods in finding an optimum or near-optimum route for the three-dimensional elevator, and it also overcomes the challenges of the non-intelligent methods. This article can help enterprises that develop multidimensional elevators in overcoming the challenges of the controller in addition to boosting the feasibility of multidimensional elevators.