bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sharing information between related diseases using Bayesian joint fine mapping increases accuracy and identifies novel associations in six immune mediated diseases
Authors: Asimit Jennifer L , Rainbow Daniel B , Fortune Mary D , Grinberg Nastasiya F , Wicker Linda S , Wallace Chris 
Published: February 2019

AbstractThousands of genetic variants have been associated with human disease risk, but linkage disequilibrium (LD) hinders fine-mapping the causal variants. We show that stepwise regression, and, to a lesser extent, stochastic search fine mapping can mis-identify as causal, SNPs which jointly tag distinct causal variants. Frequent sharing of causal variants between immune-mediated diseases (IMD) motivated us to develop a computationally efficient multinomial fine-mapping (MFM) approach that borrows information between diseases in a Bayesian framework. We show that MFM has greater accuracy than single disease analysis when shared causal variants exist, and negligible loss of precision otherwise. Applying MFM to data from six IMD revealed causal variants undetected in individual disease analysis, including in IL2RA where we confirm functional effects of multiple causal variants using allele-specific expression in sorted CD4+ T cells from genotype-selected individuals. MFM has the potential to increase fine-mapping resolution in related diseases enabling the identification of associated cellular and molecular phenotypes.
Varying involvement in digitally enhanced employee-driven innovation
Authors: Bäckström Izabelle , Lindberg Malin 
Published: February 2019

PurposeThe purpose of this paper is to advance knowledge about the mechanisms behind, and the implications of, varying involvement in digitally enhanced employee-driven innovation (EDI) by studying how a firm integrates a web-based tool in the organization of its EDI process.Design/methodology/approachBased on a qualitative in-depth interview study with managers and employees at one high-performing and one low-performing office of a global IT firm, a critical discourse analysis was performed. It explored how the EDI discourse was produced, distributed and consumed in relation to the web-based tool for collecting and selecting employee ideas.FindingsThe results demonstrate that the production of the innovation discourse by the top-level management, which emphasizes client satisfaction rather than employee engagement, restricts the employees’ utilization of the digital platform that distributes the discourse. However, at the high-performing office, employee participation is ensured because the local managers act as co-distributors of the digital tool.Research limitations/implicationsThe single case study design limits the generalizability of the results, but is nevertheless relevant for understanding the mechanisms and implications in similar contexts where web-based tools are used to enhance EDI processes.Practical implicationsThe study provides practical insights into the importance of local management’s active promotion of digital tools in order to ensure employee involvement.Originality/valueThe study contributes to the EDI literature by identifying some mechanisms behind and the implications of varying employee involvement in digitally enhanced EDI processes.
Young adult consumers’ involvement in branded smartphone based service apps
Authors: Sarkar Juhi Gahlot , Sarkar Abhigyan 
Published: February 2019

Purpose
The purpose of this paper is to investigate various factors that shape young adult consumers’ smartphone-based service app involvement and their subsequent development of brand loyalty for the app.

Design/methodology/approach
A survey was conducted to test the hypothesized relationships. The survey data were analyzed using SPSS-based PROCESS macro (Hayes, 2013).

Findings
The study results show that consumer can perceive an app to be largely hedonic or utilitarian, and the perceived app design (hedonic vs utilitarian) impacts consumers’ involvement with a particular service app category. Further, the findings elucidate that the impact of app hedonism on app category involvement is moderated by consumer’s surfing task orientation and the extent to which app arouses their imagination. On the other hand, the impact of app utilitarianism on app involvement is moderated by consumer’s information-seeking task orientation and perceived relevance of the information. Finally, app category involvement predicts loyalty toward a particular brand in the service app category. The effect of app involvement on brand loyalty is moderated by hot and cold brand relationship quality in cases of hedonic and utilitarian apps, respectively.

Originality/value
The value of this research lies in identifying relevant managerially actionable moderators that shape the relationships between perceived dominant app design (hedonic vs utilitarian), app category involvement and app brand loyalty.
Integrating community service learning into a master’s program
Authors: Zweekhorst Marjolein , Essink Dirk 
Published: February 2019

Purpose
In order to address the complex problems of society, the innovation research process should incorporate technical, social, economic and ethical factors, but also actively involve a diverse group of non-scientific actors. One way to prepare students for this type of research is to create “Citizen Scholars,” students who want to work for the betterment of society. Arvanitakis and Hornsby (2016) argue that we need to change how we teach and train students in specific proficiencies. The purpose of this paper is to assess how the pedagogical approach applied within the program contributes to building the proficiencies and attributes as described by Arvanitakis and Hornsby (2016).

Design/methodology/approach
The authors conducted a total of 12 interviews with alumni who started their program in 2014, one focus group discussion with lecturers and 132 questionnaires with alumni to discuss to what extend the proficiencies are trained in the program and whether these are used in their current jobs. The authors also included data of an earlier study conducted in 2014. These data contain 26 interviews with students during the first year of the program. These students graduated in 2017 and are thus from the same cohort as the alumni.

Findings
The results show that the pedagogical approach in the management policy analysis program trains all the attributes. Important elements in the program are: the inquiry-based approach intertwined with community service learning (CSL) throughout the program; gradually increased complexity of the real-world problems addressed; students working in teams; and gradually reducing support of the lecturer.

Research limitations/implications
The authors conclude that our pedagogical approach applied in the program contributes to learning the proficiencies. The authors argue that for the training of inter- and transdisciplinary, the proficiency knowledge integration should be added.

Practical implications
The result show that more inquiry-based approaches and CSL programs can stimulate the four clusters of proficiencies, which should hold a central place in universities if we want to create citizen scholars.

Social implications
With the approach, students contribute to research issues of local communities.

Originality/value
Despite the increasing interest of higher education to involve civic activities in the curricula, few pedagogical approaches are described. The research shows that theoretical insights in the adaption of a model to realize a citizen scholar.
A qualitative investigation of strategies and experiences of non-native students writing master’s theses
Authors: Khozaei Ravari Zahra , Tan Kok Eng 
Published: February 2019

PurposeResearch on academic writing development at graduate level has received wide attention. However, less has been documented on positive academic writing literacy experiences and strategies of non-native students while completing their master’s theses. The purpose of this paper is to examine facilitating strategies that non-native students develop in the writing-up stage.Design/methodology/approachA total of 50 MA English majors from 11 higher education institutions in Tehran participated in this qualitative study. Data were gathered using interviews and journal entries and analyzed thematically with the help of the NVivo10 software.FindingsThe analysis resulted in three major themes: self-support strategies of an academic writer; enhancing personal development; and supervisors’ support and feedback. Findings showed that Iranian students developed strategies that involved interactions not only with supervisors but also members of various academic communities that could be reached via online professional networking. There was also a need to address organizational skills and mood management to meet deadlines. Regardless of the self-support strategies, the supervisors’ role and supervisor–supervisee relationships remained crucial.Originality/valueAvailable studies in academic literacy and English for academic purposes have mainly focused on thesis challenges. This study highlights strategies and positive experiences that facilitate the progress of MA students in the thesis writing journey, while at the same time emphasizing the critical role of supervisors in expediting this process.
Providing a piece of the puzzle: insights into the aircraft availability conundrum
Authors: Ritschel Jonathan D. , Ritschel Tamiko L. , York Nicole B. 
Published: February 2019

Purpose
Aircraft availability (AA) is a key metric for assessing operational readiness. The declining trend in AA is a documented concern for senior Air Force leaders. This paper aims to investigate the components of non-available time and subsequently focuses on the largest and fastest growing category: not mission capable maintenance unscheduled (NMCMU). Then, utilization of aircraft platforms is examined to determine the readiness benefits of increasing available hours.

Design/methodology/approach
Stepwise regression is conducted on a data set of 30 aircraft platforms, consisting of 542 observations from 1998 to 2017, to reveal drivers of NMCMU. Next, utilization of aircraft platforms is examined through regression and correlation analysis of aircraft platforms and sorties or hours flown.

Findings
Regression analysis reveals drivers of NMCMU include platform type, average age of aircraft, fleet size, breaks and cannibalization. These factors explain 80.6 per cent of the variance in the data set when predicting NMCMU. Additionally, the utilization results show that when more hours are made available, 5 per cent of each new hour is used for flying. Further analysis at the individual platform level finds a strong or moderate correlation between available hours and sorties flown for 93 per cent of the platforms.

Originality/value
Implications from the regression analysis demonstrate there are remedies to increase AA, but many of these remedies may be costly. The utilization analysis expresses the potential readiness benefits of increasing available hours.
Premises recovery through adoption of alternative dispute resolution (ADR) techniques
Authors: Olapade Daramola Thompson , Olapade Biodun , Aluko Bioye Tajudeen 
Published: February 2019

Purpose
This paper aims to explore the use of alternative dispute resolution (ADR) techniques as a legitimate means of ejection of recalcitrant tenant in property. This is with a view of providing information that will improve property investment and management.

Design/methodology/approach
The paper adopts a case study approach using five selected case studies where ADR approach was used to recover premises.

Findings
The experience from the case studies shows that the use of ADR in premises recovery is effective but has its challenges. In the five case studies, consent judgment, mediation and negotiation were used to recover premises in less than three months compared to an average of 18 months using litigation. Also, the cost in all the cases were lower where they exist at all than when litigation are used. The paper provides useful information to practitioners on the use of the effective alternative approach to recover premises from recalcitrant tenants.

Originality/value
The paper provides practical ways through which recovery of premises could be achieved through non-adversarial technique in developing property markets, which hitherto was not available in literature.
How ordinary returnees and foreigners drive firms’ exports?
Authors: Hu Xiaoting , Li Jizhen , Jin Zhanming 
Published: February 2019

PurposeThe purpose of this paper is to examine the influence of ordinary returnee and foreign employees in firm export performance, whose impacts have been overseen in prior research. This study also explores whether returnee and foreign employees function as substitutes or complements, and simultaneously considers the impacts of contextual factors on the relationship between returnee (foreign) employees and firm export performance.Design/methodology/approachUsing panel data of Beijing’s Zhongguancun Science Park manufacturing firms over a seven-year period, from 2009 to 2015, the paper applies panel Tobit regression to deal with the left-censoring dependent variable.FindingsThis paper finds the number of returnee and foreign employees has significantly positive influence in promoting firm export performance; however, substitution effects exist between them. In addition, the positive effects of returnee and foreign employees on firm export performance are conditional. For foreign employees, the presence of corporate president with international background and firm imports will weaken their positive impacts. In terms of returnee employees, their positive influence proves not to be significantly reduced by corporate president’s international background but weakened by firm imports.Originality/valuePrevious research only highlights returnee entrepreneurs’ and top managers’ positive influence on firm export performance. However, with the development of emerging countries, for instance, China in this paper, ordinary returnee and foreign employees are playing more and more critical roles in firms’ internationalization process. This paper responds to the practical needs to focus on ordinary returnee and foreign employees.
Viral and bacterial community responses to stimulated Fe(III)‐bioreduction during simulated subsurface bioremediation
Authors: Liang Xiaolong , Zhuang Jie , Löffler Frank E. , Zhang Yingyue , DeBruyn Jennifer M. , Wilhelm Steven W. , Schaeffer Sean M. , Radosevich Mark 
Published: February 2019

SummaryThe delivery of fermentable substrate(s) to subsurface environments stimulates Fe(III)‐bioreduction and achieves detoxification of organic/inorganic contaminants. Although, much research has been conducted on the microbiology of such engineered systems at lab and field scales, little attention has been given to the phage‐host interactions and virus community dynamics in these environments. The objective was to determine the responses of soil bacterial communities and viral assemblages to stimulated anaerobic Fe(III)‐bioreduction following electron donor (e.g. acetate) addition. Microbial communities, including viral assemblages, were investigated after 60 days of Fe(III)‐bioreduction in laboratory‐scale columns continuously fed with acetate‐amended artificial groundwater. Viral abundances were greatest in the influent section and decreased along the flow path. Acetate availability was important in influencing bacterial diversity, microbial interactions and viral abundance and community composition. The impact of acetate addition was most evident in the influent section of the columns. The increased relative abundance of Fe(III)‐reducing bacteria coincided with an increase in viral abundance in areas of the columns exhibiting the most Fe(III) reduction. The genetic composition of viruses in these column sections also differed from the control column and distal sections of acetate‐treated columns suggesting viral communities responded to biostimulated Fe(III)‐bioreduction.
Beverage Complexity Yields Unpredicted Power Results for Seven Discrimination Test Methods
Authors: Bloom David J. , Baik Hwa‐Young , Lee Soo‐Yeun 
Published: February 2019

AbstractThe power of discrimination tests is crucial in determining sample size and resources needed for testing. Although research has been conducted on the power analysis of several discrimination testing methods, much of the previous research has focused on basic taste solutions, which may not be directly applicable to food and beverage systems. The objective of the current study was to compare the power of seven discrimination tests: Panelist‐Articulated‐2‐Alternative Forced Choice (PA‐2‐AFC), triangle, triangle with partial presentation, duo‐trio, duo‐trio with partial presentation, 4‐category rating methods for R‐index measure, and same‐different pairwise comparison for R‐index measure using commercial‐type beverage products. Sixty‐one prescreened panelists participated in the study. Six product comparisons were performed using tea, tomato juice (three comparisons), citrus‐flavored carbonated soda, and cola‐flavored carbonated soda. The tests were randomized over two testing sessions for each product comparison. Triangle testing methodologies were found to be overall the most powerful methods across product categories. The PA‐2‐AFC method was found to be the least powerful across all products. Thurstonian modeling predicts that the PA‐2‐AFC method would be the most powerful method contrary to the findings of the current study. The products tested were complex in both basic formulations and in changes made between control and variant samples. Complexity of the products may have influenced the discriminability by the panelists using different discrimination tests. Further research should be conducted to characterize the specific influence of sample complexity on the power of discrimination methodology.Practical ApplicationThere are several discrimination testing methods that can be selected when determining whether two products are significantly different. A method with high statistical power can allow researchers to save time and resources when addressing this question. The current research compares seven discrimination test methods in order to determine which method results in the highest power for several common commercial‐type beverage products. The results from this study demonstrate deviations from Thurstonian model predictions of method power revealing the need to experiment with several methods using commercial‐type products commonly tested within a business or research setting prior to selecting an optimal method to use.
Characterization of Volatile Profiles of Six Popular Edible Mushrooms Using Headspace‐Solid‐Phase Microextraction Coupled with Gas Chromatography Combined with Chemometric Analysis
Authors: Jung Mun Yhung , Lee Da Eun , Cheng Hong Yu , Chung Il‐Min , Kim Seung‐Hyun , Han Jae‐Gu , Kong Won‐Sik 
Published: February 2019

AbstractThe classification of six mushroom species (white beech, brown beech, button, oyster, king oyster, and enoki mushrooms) was successfully achieved using canonical discriminant analysis (CDA) on volatile metabolite data sets obtained by headspace‐solid‐phase microextraction gas chromatography (HS‐SPME‐GC). Twenty‐seven major volatile compounds in six edible mushrooms were positively identified by HS‐SPME‐GC mass spectroscopy. The total volatile content was highest in brown beech mushroom (P < 0.05). Significant difference in volatile profile was observed between brown beach and white beech mushrooms. Button mushroom contained significantly higher contents of benzaldehyde and benzyl alcohol than the other mushrooms (P < 0.05). Oyster mushroom contained 1‐octen‐3‐ol as the most prevalent volatile, representing 67% out of total volatiles. Hexanal (35.0%) and 1‐octen‐3‐ol (22.5%) were the most abundant volatiles found in king oyster. Hexanal (29.1%) was the most prevalent volatile in enoki mushroom only. Several volatile pairs with very high positive correlation in their levels were identified, representing the highest correlation coefficient (r = 0.970) for the pair of t‐2‐octenal and 2,4‐octandienal. CDA was much more efficient than principal component analysis for the differentiation of mushroom species.Practical ApplicationThe present study provided the important information on the volatile metabolite profiles of popular six commercial mushroom species. The present data will be useful for the quality control of mushrooms cultivated in farms and mushroom products processed in food industry. The strategy of canonical discriminant analysis in combination with HS‐SPME‐GC could be expanded for the determining the authentication of mushroom species.
Global Financial Regulation: Shortcomings and Reform Options
Authors: Jones Emily , Knaack Peter 
Published: February 2019

AbstractStandard‐setting bodies in global finance follow a core‐periphery logic, imposing a rigid dichotomy between standard‐setters and standard‐takers. They also focus exclusively on promoting financial stability. We argue that both attributes are increasingly problematic in today's world of globalised finance. Developing countries outside of standard‐setting bodies are highly integrated into global finance and while they are not systemically important, they are greatly affected by the regulatory decisions taken in the core. Analysing Basel banking standards, we show how the two‐tier structure of decision‐making results in international standards that generate adverse implications for countries in the periphery, particularly developing countries. Focusing on debates over the regulation of non‐bank credit intermediation, we show how the exclusive focus on financial stability can operate to the detriment of other important policy objectives, including financial inclusion. To improve the efficacy of international standard setting we make a series of recommendations aimed at increasing the applicability of standards to a wide variety of jurisdictions, and widening the focus of standard‐setting beyond financial stability. We also propose the creation of a new standard‐setting body for the regulation of fintech that models a more inclusive and holistic approach.