bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-Inflammatory Cytokine (IL-10) Profiles and Ratio of IL-6/IL-10 in Covid-19 Patients
Authors: Sari Shinta Dewi Permata , Listiyaningsih Erlin , Mawanti Wening Tri , Martalena Dewi 
Published: October 2024

Background: The number of COVID-19 cases in Indonesia has continually increased since the first cases appeared in March 2020. This disease is due to SARS-CoV-2 virus infection in the respiratory system that induces an immune response. The innate and adaptive immune response triggered the secretion of an excessive pro-inflammatory cytokine-caused cytokine storm that became one of the mechanisms of acute respiratory distress (ARDS). The anti-inflammatory cytokines (IL-10, IL-13, and IL-4) were secreted as the immune response in the ARDS condition. Purposes: This study aims to determine the ratio of the IL-6/IL-10 profile as basic information for the therapeutic approach to prevent ARDS. Methods: This cross-sectional study used stored biological material in plasma form from COVID-19 patients in Jakarta Islamic Hospital – Pondok Kopi and Dr. M. Goenawan Partowidigdo Hospital, Cisarua. The plasmas were from severe (n=20) patients and mild to moderate severity (n=25). The negative control sample was collected from 13 healthy subjects. Assessment of IL-10 levels in plasma using ELISA technique. Results: Our analysis showed that IL-10 has no statistical difference between negative control, mild to moderate, and severe categories (p=0.629). Meanwhile, the ratio IL-6/IL-10 presented statistical differences between mild to moderate and severe categories (p=0.011). The average ratio of IL-6/IL-10 in severe categories is two-fold higher than in mild-moderate categories. Conclusion: We conclude that there is a cytokine storm condition in severe COVID-19 patients with an imbalance ratio of pro-and anti-inflammatory cytokines and could be used as basic information for drug development in cytokine storm conditions to prevent ARDS.
The Organizational Image of The Federal Institute of Maranhão: A Study From The Students’ Perspective
Authors: Rodrigues Katarina Andrade , Costa Júnior Lindemberg , Silva Leonilde da Conceição , Gomes Patrick da Silva 
Published: October 2024

Objective: The objective of this study is to compare the attributes that influence the organizational image perceived by freshmen and senior students of the same educational institution.

Theoretical Framework: The study of the organizational image within educational institutions is of fundamental importance to guarantee quality teaching. Education must be something tangible and a right for everyone. Therefore, it is important to have this right to quality education assured. Based on studies by Santos (2016), a structured questionnaire was adapted into 39 (thirty-nine) questions.

Method: We opted for a quantitative methodology, with a descriptive and cross-sectional character. Primary data collection was adopted through in-person application of questionnaires.

Results and Discussion: The data confirm the hypothesis that the organizational image of freshmen is more optimistic than that of veterans. On average, IFMA students tend to be more discerning. It is suggested that freshmen enter the institution with a formed idea and that over time they tend to change. As a limitation, it is mentioned that responses from 9 campuses in the state of Maranhão were analyzed. However, there are a total of 29 campuses spread across the state. An analysis could be carried out in more institutions in order to obtain more general results of the organizational image at the IFMA institution in a larger portion of institutions in Maranhão.

Research Implications: As a practical contribution, the results obtained in this study can provide organizations involved with educational institutions with a holistic view of the traits of a good organizational image, awakening new learning interests in students towards the institution.

Originality/Value: This research contributes to scientific literature by advancing themes relating to quality management, organizational image, organizational image in educational institutions and public management
Elaboración de una tortilla de maíz enriquecida con zanahoria (Daucus carota) y linaza (Linium usitatissimum) para controlar enfermedades cardiovasculares.
Authors: Martínez Hernández Paola de los Ángeles , González Ortega Luis Alberto , Blasco López Gabriela 
Published: October 2024

Introducción. Las enfermedades cardiovasculares son unas de las principales causas de muerte en todo el mundo. Para hacerle frente, estudios muestran la utilidad de consumir alimentos funcionales que brinden un efecto protector y reduzcan los riesgos, como la zanahoria y linaza. Objetivo. Desarrollar una totilla de maíz enriquecida con zanahoria y linaza que contribuya al control de enfermedades cardiovasculares. Para lograr el objetivo planteado, los objetivos específicos incluyeron formular un producto a base de zanahoria y linaza, realizar una evaluación sensorial y analizar bromatológicamente el producto desarrollado enriquecido con zanahoria y linaza. Metodología. Se realizaron tres formulaciones variando las cantidades de las materias primas, se sometieron a evaluación sensorial y bromatológica. Resultados y discusión. Tortilla de 50g aporta 68.7 kilocalorías, 12.2g de carbohidratos, 1.6g de proteína, 1.5g de lípidos, 2.9g de fibra y 1.3g de betacarotenos. En comparación con una tortilla tradicional contiene menos grasa saturada, es alta en fibra y betacarotenos. Conclusión. La elaboración de la tortilla se pudo llevar acabo con los ingredientes seleccionados, tuvo una aceptación socialmente satisfactoria y podría contribuir a controlar enfermedades cardiovasculares.

Introduction. Cardiovascular disease is one of the leading causes of death worldwide. To address them, studies show the usefulness of consuming functional foods that provide a protective effect and reduce risks, such as carrots and flaxseed. Objective. Develop a corn tortilla enriched with carrots and flaxseed that contributes to the control of cardiovascular diseases. To achieve the stated objective, the specific objectives include formulating a product based on carrot and flaxseed, carrying out a sensory evaluation and bromatological analyzing the developed product enriched with carrot and flaxseed. Methodology. Three formulations were made, varying the amounts of raw materials, and were subjected to sensory and bromatological evaluation. Results and discussion. A 50g tortilla provides 68.7 kilocalories, 12.2g of carbohydrates, 1.6g of protein, 1.5g of lipids, 2.9g of fiber and 1.3g of beta-carotene. Compared to a traditional tortilla, it contains less saturated fat, is high in fiber and beta-carotene. Conclusion. The preparation of the tortilla could be carried out with the selected ingredients, had a socially satisfactory acceptance and could contribute to the control of cardiovascular diseases.
Keywords. Cardiovascular disease, Nutrient, Prevention, Functional food, Tortilla, Flaxseed, Carrot.
Breve panorama de recursos humanos en salud de Veracruz 2022
Authors: Muños Hernández José Alberto , Gutiérrez Alba Gaudencio , Armenta Arellano Sealtiel , Montero Mora Judith Guadalupe , Aguilar Ye Arturo , Coronel Brizio Pedro Guillermo , De Dios Hernández Luis Antonio , Hernández Pale Elisa Margarita 
Published: October 2024

El Observatorio de Recursos Humanos y Necesidades Prioritarias en Salud de la Universidad Veracruzana tiene como objetivo analizar la situación actual y futura de los recursos humanos y las necesidades prioritarias en el ámbito de la salud. Objetivo: Ofrecer un panorama general sobre los recursos humanos que laboran en las instituciones públicas de salud del estado de Veracruz. Métodos: Se consultaron las bases de datos del año 2022 de la Dirección General de Información en Salud, el Instituto Nacional de Estadística, Geografía e Informática (INEGI) y el Consejo Nacional de Población (CONAPO). Se realizó un análisis por jurisdicción sanitaria de las instituciones públicas de salud en Veracruz. Resultados: Veracruz cuenta con 9 974 médicos, 3 016 médicos en formación, 19 041 enfermeras, 750 odontólogos, 732 químicos clínicos, y un número menor de psicólogos, técnicos y nutriólogos. Las jurisdicciones con mayor cantidad de recursos humanos fueron Xalapa y Veracruz, mientras que Martínez de la Torre, Cosamaloapan y San Andrés Tuxtla presentaron los porcentajes más bajos. En 2022, existían 2 008 establecimientos de salud distribuidos en los tres niveles de atención.

Overview of human resources in health in Veracruz 2022
Abstract: The Human Resources and Priority Health Needs Observatory at Universidad Veracruzana focuses on analyzing the current and future status of health sector human resources. Objective: To provide a baseline overview of the human resources working in public health institutions across the state of Veracruz. Methods: Data from 2022 was gathered from the General Directorate of Health Information and the National Population Council; public health institutions in Veracruz were analyzed by health jurisdiction. Results: Veracruz has 9,997 physicians, 3,016 physicians in training, 19,041 nurses, 750 dentists, 732 clinical chemists, and smaller numbers of psychologists, technicians, and nutritionists. The health jurisdictions with the highest concentration of human resources were Xalapa and Veracruz, while Martínez de la Torre, Cosamaloapan, and San Andrés Tuxtla had the lowest. In 2022, there were 2,008 healthcare facilities across all three levels of care.
Estimation of the concentration of some biochemical parameters and bacterial profile in patients with periodontitis and its relationship with cardiovascular disease
Authors: Raad Saleh Duaa , Firas Faris rija  
Published: October 2024

Background: Concerning the widespread occurrence of hyperlipidemia, a significant risk factor for cardiovascular disease, and unclear findings on the connection between periodontal disease and the levels of lipids in the blood. Aim of the study: This study aimed to isolation different bacterial type from periodontitis patients and evaluated level of lipid profile in the same patients
Material and methods: The study included a collection age group of 90 samples swaps (patient and control), 60 samples from patients with periodontitis attending outpatient clinics and Balad General Hospitalthe sample were collected for different ages between 15-55 years old and both sexes, from july 2023to December 2024. The sample was taken using a sterile cotton swab (transport cotton swab). The blood samples were taking from their arms from (cubital vien), 5cc of venous blood taken from patients & control healthy individual, Samples were cultured directly using the plotting method on culture media suitable for bacterial growth, which included blood agar, MacConkey agar, mannitol salt agar, MSB agar, and chromo agar. The plates were incubated upside down at 37°C for 18–24 days. The bacterial isolates were identified based on physiological tests and biochemical tests.
Result: The present study’s result showed About (60%) showed positive bacterial growth which were Prophyromonas gingivalis (30%), Staph. aureus (16.7%), Strep. pneumonia (11.7%), Staph. epidermidis (10%), Strep. pyogenes, Strep. Viridans, Strep. mutans (8.3% %) for them, and (6.7%) for Enterococcus fecalis that was diagnosed based on biochemical tests, and the diagnosis of some bacterial species was confirmed with the VITEK device., whereas (40%) showed no growth, And there were a high significant differences between the periodontitis patient compared with control group in mean level of cholesterol, HDL and LDL which scored (151.1±42.7, 139.9±41.4, 184.9±25.4) respectively in patient compared with controls (80.0±16.8, 46.2±14.6, 99.1±27.1). While Triglyceride and VLDL showed no differences between studied groups. Conclusion: This study concluded increase cholesterol and low-density lipoprotein in periodontitis patient, While no differences in Triglyceride and VLDL level
Роль гена ACE в развитии тяжелой формы COVID-19 у беременных женщин
Authors: М.О. Комилова , К.Т. Бобоев , Ш.А. Зуфарова , А.С. Юлдашева 
Published: October 2024

Использование генетических полиморфизмов при определении патогенеза заболевания повышает эффективность ранней диагностики и профилактики тяжелой формы коронавирусной инфекции. COVID-19 и его осложнения пневмонией являются потенциальным фактором риска для беременных и могут иметь негативные последствия как для матери, так и для плода. В настоящее время особое внимание уделяется изучению роли генетических факторов в возникновении вспышки коронавируса. Цель исследования: определить роль полиморфизма I/D Alu-элемента гена ACE в патогенезе COVID-19. По результатам молекулярно-генетического обследования и статистического анализа частоты аллелей и генотипов полиморфизма I/D гена ACE у беременных, инфицированных коронавирусом, не имели достоверных отличий от таковых в контрольной группе (р=0,05) и, таким образом, этот полиморфизм не ассоциирован с развитием COVID-19 и его осложнений.
The use of genetic polymorphisms in determining the pathogenesis of the disease increases the effectiveness of early diagnosis and preventive measures of severe form of coronavirus. COVID-19 and its complications with pneumonia are a potential risk factor for pregnant women and can have negative consequences for both the mother and the fetus. Currently, special attention is paid to the study of the role of genetic factors in the outbreak of the coronavirus. The aim of the study: to determine the role of the ACE gene Aluelement I/D polymorphism in the pathogenesis of COVID-19. According to the results of molecular-genetic examination and statistical analysis, alleles and genotypes of ACE gene I/D polymorphism in pregnant women infected with coronavirus did not have significant differences compared to the control group (p=0.05). Conclusion: It is impossible to use this locus of the ACE gene to predict COVID-19 and its complications.
Application Of Reading Card Media To Improve Early Grade 2nd Reading Aloud Skills SD Inpres Barombong 2 Kecamatan Tamalate Kota Makassar
Authors: Nursintiah Lulu , Tati Andi Dewi Riang , Lutfi Lutfi 
Published: October 2024

The problem behind this research is the low reading ability of class II students at SD Inpres Barombong 2, Tamalate District, Makassar City. This study aims to improve the ability to read aloud students of class II SD Inpres Barombong 2 Tamalate District, Makassar City. The approach used in this research is a qualitative approach and a type of classroom action research (CAR), which consists of II cycles with activity stages in the form of planning, implementing, observing and reflecting. The focus of this research is the use of reading cards to improve students' reading aloud skills. The research subjects were teachers and students of class II SD Inpres Barombong 2, Tamalate District, Makassar City. In the odd semester of the 2022/2023 school year, a total of 25 students. Data collection uses the format of observation, tests, and documentation. The data analysis used is qualitative. The results showed that there was an increase in learning both in teacher and student activities and in students' reading skills. The results of this study are that the teacher's teaching activities and student learning activities have increased, it can be seen in the average value produced in cycle 1 which is 63.2 and cycle II to 85.2. In addition, the results of observations of teacher teaching activities in cycle 1 were in the less category (K) while in cycle II they were in the sufficient category (C). Student activity in cycle 1 is in the sufficient category (C), and cycle II is in the good category (B). The conclusion of this study is that the use of reading cards media can improve the reading skills of class II students at SD Inpres Barombong 2, Tamalate District, Makassar City. Keywords: Reading card learning media, reading aloud skills
Optimizing STEM Education via e-Learning: Addressing Challenges and Strategic Planning for Graduate Employment Outcomes
Authors: Al Shamsi Ibrahim Rashid 
Published: October 2024

This study fills a significant vacuum in the literature and offers insightful information, especially pertinent to the Arabic and Gulf areas. In support of the socioeconomic development and diversification initiatives in these areas, it encourages the creation of educational policies and practices that can improve student job chances. Educators and policymakers play a crucial role in implementing these recommendations, ensuring that effective STEM education equips future generations with the knowledge and skills to navigate and secure digital environments, mitigating risks posed by cyber threats. By preparing students to excel in STEM disciplines, they ensure that the future workforce is ready to contribute to and shape a safer, more innovative future. Today's STEM workforce requires continuous education to stay abreast of advancements in STEM fields. Online delivery of STEM courses enables higher education institutions to collaborate effectively with industry partners, minimizing disruptions to productivity. This study aims to evaluate the enhancement of students' STEM knowledge and skills through e-learning platforms using Structural Equation Modeling (SEM). The dataset comprises 212 participants and 15 indicators, analyzed using measurement and structural models. Results indicate significant findings supporting hypotheses: E-Learning (E.L.) improving Student employment opportunities (SEO) (B=0.539, t=8.884, p=0.000) and E.L. improving STEM (B=0.465, t=8.849, p=0.000), validating H1 and H2, respectively. H3 explores how possessing STEM knowledge mediates E-Learning's impact on SEO, revealing a notable indirect relationship (B=0.082, t=2.303, p=0.021). Integrating E-Learning with STEM fosters a robust digital infrastructure, addressing talent shortages and improving human resource management amidst global technological advances. Online STEM courses are increasingly recognized as a viable solution to national STEM challenges, overcoming traditional adoption barriers. Doi: 10.28991/ESJ-2024-SIED1-014 Full Text: PDF
Pengetahuan dan Perilaku Cerdik Penyakit Tidak Menular terhadap Kejadian Hipertensi
Authors: Sundari Muhrida Septiana , Juniarti Neti , Sari Sheizi Prista 
Published: October 2024

ABSTRACT Hypertension is a non-communicable disease that is still the leading cause of death globally and nationally. This study aims to analyze the relationship between knowledge and behavior of CERDIK PTM on the incidence of hypertension in the target of Posbindu in Ciwalen Village, Garut Regency. The research method used is quantitative research with a cross sectional approach. The results showed that there was a relationship between knowledge (p=0.000), and CERDIK NCD behavior (p=0.002) with the incidence of hypertension. In conclusion, there is a relationship between the knowledge and behavior of CERDIK PTM and the incidence of hypertension. Keywords: CERDIK NCD, Hypertension, Knowledge ABSTRAK Hipertensi merupakan penyakit tidak menular yang masih menjadi penyebab utama kematian secara global dan nasional. Penelitian ini bertujuan untuk menganalisis hubungan antara pengetahuan dan perilaku CERDIK PTM terhadap kejadian hipertensi pada sasaran Posbindu di Kelurahan Ciwalen, Kabupaten Garut. Metode penelitian yang digunakan adalah penelitian kuantitatif dengan pendekatan cross sectional. Hasil penelitian menunjukkan bahwa terdapat hubungan pengetahuan (p=0,000), dan perilaku CERDIK PTM (p=0,002) dengan kejadian hipertensi. Ada hubungan antara pengetahuan dan perilaku CERDIK PTM dengan kejadian hipertensi. Kata Kunci: CERDIK PTM, Hipertensi, Pengetahuan
Penerapan Intervensi Perendaman Kaki dengan Rebusan Air Serai dan Garam pada Penderita Hipertensi Terhadap Penurunan Tekanan Darah
Authors: Saputri Defika Drajat , Muhlisin Abi 
Published: October 2024

ABSTRACT Hypertension, or high blood pressure, is a condition where arterial blood flow experiences a pressure that is higher than normal, namely 120/80 mmHg in adults. Treatment of hypertension is necessary, not only to lower blood pressure levels but also to prevent the disease from getting worse. Soaking the feet in warm water provides a local response to heat through this stimulation, which will send impulses from the periphery to the hypothalamus. To determine the effect of soaking feet in boiled salt water and lemongrass on lowering blood pressure in hypertensive patients. This scientific work uses a case study design by providing an intervention from evidence-based nursing in the form of the Benson relaxation technique for ± 10 minutes given to four hypertensive patient subjects. Based on the results of applying foot soak therapy in boiled salt water and lemongrass, it showed an effect on lowering blood pressure in the four subjects. Based on the results of the application and description of foot soaks in boiled salt and lemongrass, the author concludes that foot soaks can be a non-pharmacological technique that can influence blood pressure in hypertensive patients to speed up the patient's recovery. Keywords: Hypertension, Lemongrass Decoction, Salt, Blood Pressure ABSTRAK Hipertensi atau tekanan darah tinggi (high blood pressure) merupakan kondisi dimana aliran darah arteri mengalami tekanan yang lebih tinggi dari kondisi normal yaitu pada 120/80 mmHg pada orang dewasa. Pengobatan hipertensi diperlukan, tidak hanya untuk menurunkan tingkat tekanan darah tetapi untuk mencegah penyakit dari komplikasi. Merendam kaki dengan air hangat memberi respon lokal terhadap panas melalui stimulasi ini akan mengirimkan implus dari perofer ke hipotalamus. Untuk mengetahui pengaruh rendam kaki air rebusan garam dan serai dalam menurunkan tekanan darah pasien hipertensi. Karya ilmiah ini menggunakan rancangan studi kasus (case study) dengan pemberian intervensi dari Evidance Based Nursing berupa teknik relaksasi benson selama ±10 menit yang diberikan pada empat subjek pasien hipertensi. Berdasarkan hasil penerapan terapi rendam kaki air rebusan garam dan serai menunjukan adanya pengaruh dalam menurunkan tekanan darah pada ke empat subjek. Berdasarkan hasil penerapan dan uraian tentang rendam kaki air rebusan garam dan serai, penulis menyimpulkan bahwa rendam kaki bisa menjadi salah satu teknik non farmakologis yang dapat memepengaruhi tekanan darah pada pasien hipertensi untuk mempercepat pemulihan pada pasien. Kata Kunci: Hipertensi, rebusan serai, garam, tekanan darah
Comprehensive Analysis of Codon Usage Bias in Human Papillomavirus Type 51
Authors: Tan Xiaochun , Bao Siwen , Lu Xiaolei , Lu Binbin , Shen Weifeng , Jiang Chaoyue 
Published: October 2024

Abstract
Human papillomavirus type 51 (HPV-51) is associated with various cancers, including cervical cancer. Examining the codon usage bias of the organism can offer valuable insights into its evolutionary patterns and its relationship with the host. This study comprehensively analyzed codon usage bias in HPV-51 by examining 64 complete genome sequences sourced from the NCBI GenBank database. Our analysis revealed no noteworthy preference for codon usage in HPV-51 overall. However, there was a noticeable bias towards A/T-ending codons, accompanied by GC3s below 32%. Dinucleotide frequency analysis revealed reduced frequencies for ApA, CpG, and TpC dinucleotides, while CpA and TpG dinucleotides were more frequent than others. Relative Synonymous Codon Usage analysis revealed 30 favored codons, primarily concluding with A/T nucleotides. Further analysis using Parity Rule 2, Effective Number of Codons plot, and neutrality plot indicated a balance between mutational pressure and natural selection, with natural selection being the primary force shaping codon usage bias. The Isoacceptor tRNA Pool analysis indicates that HPV-51 has a higher translation efficiency within the human cellular translational system. Moreover, the Codon Adaptation Index and Relative Codon Deoptimization Index analyses suggested a moderate adaptation of HPV-51 to human codon preferences. Our discoveries offer valuable perspectives on how HPV-51 evolves and uses genetic codes, contributing to a deeper comprehension of its endurance and disease-causing potential.