bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of novel CDK2 inhibitors for cancer treatment: integrating ligand-based pharmacophore modelling, molecular docking, DFT, ADMET, and molecular dynamics simulation studies
Authors: Chagaleti Bharath Kumar , Saravanan Venkatesan , Kathiravan M. K. 
Published: November 2024

Abstract
Background
The global landscape of public health faces significant challenges attributed to the prevalence of cancer and the emergence of treatment resistance. This study addresses these challenges by focusing on Cyclin-dependent Kinase 2 (CDK2) and employing a systematic computational approach for the discovery of novel cancer therapeutics.

Results
Initial ligand-based pharmacophore modelling, utilizing a training set of five reported CDK2 inhibitors, yielded a robust model characterized by Aro|Hyd| and |Acc|Don| features. Screening this validated model against the ZINC database identified 1881 hits, which were further subjected to molecular docking studies. The top 10 compounds (Z1–Z10) selected from the docking studies underwent Pharmacokinetic parameters Absorption, Distribution, Metabolism, Excretion and Toxicity profiling, Density Functional Theory (DFT) studies and the top two went for 100ns molecular dynamics (MD) simulations by comparing them with the standard Roscovitine. Compounds Z1 and Z2 emerged as the most promising, with docking scores of − 8.05 kcal/mol and − 8.02 kcal/mol, respectively. DFT analysis of the top 10 compounds revealed minimal variations in highest occupied molecular orbital–lowest unoccupied molecular orbital energy gaps, indicating consistent electronic stability and reactivity across the candidates. MD simulations of Z1 and Z2 confirmed their stable interactions with CDK2, with root mean square deviation (RMSD) values ranging from 1.4 to 2.5 Å for Z1 and 1.5 to 2.4 Å for Z2.

Conclusion
The current research identified compounds Z1 and Z2, which demonstrated significant potential as potent CDK2 inhibitors for cancer therapy, providing valuable insights into the development of more effective CDK2 inhibitors and addressing the critical need for innovative therapeutic strategies in cancer treatment.

Graphical abstract
Gwendolyn Brooks: Who Ya Talkin’ With?
Authors: Foster Tonya M. 
Published: November 2024

Abstract
This essay looks at the shifting poetic and aesthetic strategies that Gwendolyn Brooks employed over her more than fifty-year career. The first Black American poet to receive a Pulitzer Prize for Poetry, Brooks initiates a lineage of poetry and poets dedicated to attending to the daily conditions of Black life in America. Long a poet of daily Black life, Brooks announces via her poetry an aesthetics committed to, in the words of Langston Hughes, “the inherent expressions of Negro life in America: the eternal tom-tom beating in the Negro soul — the tom-tom of revolt against weariness in a white world, a world of subway trains, and work, work, work; the tom-tom of joy and laughter, and pain swallowed in a smile.” Through textual analyses of the language of several of Brooks's poems alongside interviews with Brooks and critical essays about Brooks's work, this essay points to Brooks as the poet most steadfastly exploring what philosopher George Yancy describes as “the lived density of race.” Yancy notes that “while the focus on demonstrating the nonreferential status of race is important work within the context of liberation praxis vis-a-vis racism — indeed indispensable work —  . . . it is at the level of the lived density of race that so much more work needs to be done.” This is the work of Gwendolyn Brooks's art.
Order and Archive: A Foucault Abecedary
Authors: Huffer Lynne 
Published: November 2024

Abstract
This essay reviews the first and last volumes of Stuart Elden's four-volume intellectual biography of Michel Foucault, The Early Foucault (2021) and Foucault's Last Decade (2016). It borrows from Roland Barthes an abecedarian method to experiment with the play between order and archive that subtends Elden's Foucault series. Like Foucault, Elden deploys an explicitly archival method for thinking philosophically. That method brings both historiographical and conceptual clarity to our understanding of Foucault within the chronological frame of his life. As a poetic order, the acrostic experimentation of abecedarian writing brings into view the nonchronological archival murmur that both shapes and exceeds Elden's ordering of fragments in dossiers and the gaps between them.
Writer and Thinker
Authors: Eiland Howard 
Published: November 2024

Abstract
In The Benjamin Files (2020), Fredric Jameson showcases Benjamin the writer. Adapting Roland Barthes's term “writerly” (scriptible), he emphasizes the panoramic variety of Benjamin's production together with its experimental character, its deployment of montage techniques akin to those of filmmakers and poets of his day. Jameson shows how the polyphony and multiperspectivity of Benjaminian forms reflect a monadological theory of history as “periodization without transitions.” Pablo Oyarzun's Doing Justice: Three Essays on Walter Benjamin (translated by Stephen Gingerich, 2020), views Benjamin in the context of a philosophic eventism and an ontological theory of language as revelation. Underscoring the centrality of the concepts of experience and translation in Benjamin's thinking, and providing relevant personal testimony concerning recent Chilean history, Oyarzun presents Benjamin as the “thinker of justice.” The call for justice, understood as a nonlegalistic promissory directive, entails a philosophical-historical stewardship: doing justice means worldly attentiveness to the particularity of things.
Dayanita Singh's World of Books
Authors: Sichel Kim 
Published: November 2024

Abstract
This review essay examines three recent photobooks by Dayanita Singh: Let's See, Book Building, and Dancing with My Camera, which show the evolution and singularity of her work. Singh's main medium is an essential form of photographic communication: the photographic book. As a documenter, a photographic book artist, and a conceptual artist, she and her work have transformed and conflated our definitions of what it takes to construct a book, an archive, or an exhibition. Singh creatively conflates the distinctions between exteriorizing documentary and inward-looking autobiography. She explodes the somatic concepts of bodily viewing photography, intertwining the acts of physically walking through an exhibition, holding a book in one's hands, and leafing through a file folder. Her projects interrogate concepts of family, technology, belonging, and identity.
Purely Endoscopic Subtemporal Keyhole Approach for Trigeminal Schwannomas: Surgical Techniques and Early Results
Authors: Sasaki Tsuyoshi , Morisako Hiroki , Beniwal Manish , Ikeda Shohei , Nagahama Atsufumi , Ikegami Masaki , Ohata Kenji , Goto Takeo 
Published: November 2024

BACKGROUND AND OBJECTIVES:
In the past, microscopic transcranial approach was the mainstay of treatment of trigeminal schwannomas. In recent years, several endoscopic procedures have been reported for trigeminal schwannomas. For trigeminal schwannomas arising around the Meckel cave, we introduced a fully endoscopic procedure with a small temporal craniotomy in June 2020 and have performed radical tumor removal as in the conventional approach. This article describes the details of the purely endoscopic subtemporal keyhole approach (PESKA) surgical procedure and reports the initial surgical results.

METHODS:
Between June 2020 and November 2023, 8 cases of trigeminal schwannoma were treated with PESKA. The mean tumor diameter was 33.1 mm. The surgical procedure for PESKA consists of a 7-cm linear skin incision made upward from the anterior to the auricle on the side of the lesion, followed by a 4-cm temporal craniotomy and then endoscopic manipulation. The intradural part of the middle cranial fossa is observed, and the Meckel cave is identified and opened. The tumor is removed with preserving most normal trigeminal nerve fibers. The site of the lesion, the extent of resection, complications, operative time, Karnofsky Performance Status, and intraoperative blood loss were evaluated.

RESULTS:
All 8 patients underwent gross total resection. Only one patient had new temporal edema on the side of the lesion, which was asymptomatic. The mean operative time was 4 hours and 21 minutes.

CONCLUSION:
We report on PESKA, a fully endoscopic procedure with a small temporal craniotomy for a trigeminal schwannoma arising around the Meckel cave. The use of an endoscope allowed for a wide field of view, even in a narrow operative field, reducing brain traction and allowing radical resection of the tumor while preserving normal trigeminal nerve fibers. This method may represent an effective surgical alternative for trigeminal schwannomas.
LOGISTICS AND EFFICIENCY OF HEAVY TRAFFIC
Authors: Pokrovskaya Oksana D. , Shugaev Oleg V. 
Published: November 2024

Background. The article is devoted to the study of the organization of the heavyweight movement. The relevance of the topic is related to the steady increase in the average weight of freight trains operating on heavily loaded routes of Russian railways and the corresponding need for a comprehensive assessment of the potential of heavy traffic.
Purpose: to characterize the problematic issues of logistics of heavy traffic in the conditions of the Russian Federation, caused by mixed traffic, different landscape and climate of our country, as well as the reorientation of cargo flows to the east, are considered.
Methods. Methods of comparative analysis, logistics, norming of operational work of railroads, visualization were used.
Results. An analytical review of the problematic field of the organization of heavy traffic from the standpoint of logistics has been performed. The peculiarities of logistics are revealed, relevant development tracks and challenges arising in the organization of heavy traffic are formulated. An integral indicator is proposed – the Index of the development potential of heavy traffic for a comprehensive assessment of the effectiveness of organizing both a separate route and related multiplicative effects.
Conclusion. It is shown that the use of the indicator will provide a scientifically sound solution to the problem of increasing the capacity of railways in answering the problematic issues of heavy traffic identified in the study.
Learning to Schedule in Multiclass Many-Server Queues with Abandonment
Authors: Zhong Yueyang , Birge John R. , Ward Amy R. 
Published: November 2024

How to Learn Which Customer Class to Serve Next? In “Learning to Schedule in Multiclass Many-Server Queues with Abandonment”, Zhong, Birge, and Ward tackle the challenge of scheduling (that is, how to choose the customer that a newly available server will serve) in a multiclass many-server queueing system where customers may abandon the queue. The goal is to develop a scheduling policy that performs nearly as well as a benchmark policy under full knowledge of the model primitives despite these primitives being unknown and needing to be learned. They propose a Learn-then-Schedule policy that first estimates the unknown model primitives empirically and then schedules according to the benchmark policy structure using these estimates. Such a policy achieves an optimal regret rate of order logT (where T is the system time), meaning that the performance gap between the proposed policy and the benchmark policy grows logarithmically over time.
The impact of blended-ESP instructional model on fostering English proficiency among students majoring in traditional Chinese medicine
Authors: Yu Ruirui , Champakaew Wilawan 
Published: November 2024

English proficiency is essential for traditional Chinese medicine (TCM) majors to maintain strong connections with the international academic community and promote global academic interaction. However, the English instruction effect was not optimal due to large class sizes, limited class time and learning resources, less interaction, or outdated teaching and evaluation methods (Wang, 2016; Ren, 2017; Chen & Liang, 2020; Liu, 2022). This study aimed to investigate the impact of the blended-ESP instructional model (BEIM) on fostering students’ English proficiency as well as explore their attitudes and perspectives on the implementation of BEIM. The participants were 73 second-year TCM majors enrolled in the TCM English course at a TCM university in China. The instruments were pre- and post-tests, a questionnaire, and an interview. The data was analyzed using mean, standard deviation, paired t-test, segmented analysis, and thematic analysis. The results demonstrated the effectiveness of BEIM on fostering students’ English proficiency for the significant differences between the scores before and after implementing BEIM at 0.000 (P= 0.000). The results of the questionnaire and interview also revealed students’ positive attitudes and perspectives on BEIM. Students’ self-disciplinary, English proficiency, and national culture awareness and confidence should be highlighted when conducting blended-ESP instruction.
FAVELAS E PERIFERIAS URBANAS: aspectos do cotidiano popular
Authors: Brum Mario , Benmergui Leandro , Gonçalves Rafael Soares 
Published: November 2024

Periferia e Favela... por muito tempo, esses dois conceitos foram construídos a partir de dois eixos que os definiam: o da distância e/ou o da ausência. Esses eixos em si, mais do que explicar, acabavam por criar quimeras sobre a favela e a periferia, reificando os seus lugares mais simbolicamente do que espacialmente; mais tratando-os como lócus de problemas do que de soluções; mais vendo seus moradores como vítimas do que como sujeitos.
O DESAFIO DAS INSTITUIÇÕES DE ENSINO SUPERIOR (IES) EM IMPLEMENTAR NA CURRICULARIZAÇÃO DA EXTENSÃO AS MUDANÇAS CLIMÁTICAS
Authors: Xabregas Quézia Fragoso , Brasileiro Tania Suely Azevedo 
Published: November 2024

As mudanças climáticas têm cada vez mais preocupado o mundo. Relatórios oficiais do IPCC[1] mostram que a crise do clima se torna mais grave a cada época. Fenômenos naturais, e/ou antrópicos, proporcionam destruições, tragédias, catástrofes e danos irreversíveis à natureza e ao ser humano. Diante dessa realidade, por entender o compromisso socioambiental das IES, e com a regulamentação da Resolução nº 7, de 18 de dezembro de 2018, que estabelece as Diretrizes para a Extensão na Educação Superior Brasileira, o estudo tem como objetivo evidenciar e analisar a temática mudanças climáticas na curricularização da extensão, e elucidar a responsabilidade das IES em meio a um possível caos climático global. A Pesquisa é do tipo bibliográfica e documental. (LISBOA FILHO, 2022); (GOMES, 2020); (IMPERATORE; PEDDE,2016); (REIS, 2017); (GOMES; BRASILEIRO; CAEIRO, 2020); (MERENGO; SOUZA, 2021); (CLIMATE-U, 2020) entre outros, fundamentam bibliograficamente essa pesquisa, e as legislações vigentes que tratam da temática. O estudo mostrou a incumbência da instituição de ensino superior no enfretamento às mudanças do clima. Nesta perspectiva, espera-se contribuir na formação inicial de futuros profissionais comprometidos com as questões climáticas.[1] O Painel Intergovernamental sobre Mudanças Climáticas (Intergovernmental Panel on Climate Change) é um órgão que foi criado em 1988 pela Organização das Nações Unidas (ONU). Organiza relatórios completos das avaliações referentes à conjuntura do conhecimento científico, técnico e socioeconômico sobre as mudanças climáticas, riscos e impactos futuros. Evidencia possibilidades para reduzir os efeitos causados pelas mudanças do clima.
Family Resilience in Families of Children With Autism Spectrum Disorders: Ecological Systems Theory Perspective
Authors: Gur Ayelet , Meir Yifat Bar , Edelstein Maayan , Nagar Mirit , Rokach Òrly , Reich Ari , Hindi Tali-Noy 
Published: November 2024

Abstract
Drawing on Bronfenbrenner’s ecological systems theory (1992), we asked how certain resources contribute to family resilience in families of children with ASD: family quality of life (FQOL; family resources), sense of community and loneliness (informal resources), and family-centered support provided by the state (formal resources). One hundred and twenty-one Israeli parents of children with ASD completed an online survey. Path analysis using AMOS was conducted. FQOL contributed to increased family resilience. Path analysis showed loneliness, sense of community, and services use contributed to family resilience through FQOL. Overall, the research model explained 68% of the variance in family resilience. Implications for research and practice are discussed.
Establishing an Advocacy Activities Scale for Parents of Individuals With Intellectual and Developmental Disabilities
Authors: Li Chak , Burke Meghan M. , Taylor Julie Lounds , DaWalt Leann S. , Rossetti Zachary 
Published: November 2024

Abstract
Advocacy has long been heralded as a way to create change for individuals with intellectual and developmental disabilities (IDD) and their families. However, without an established measure, it is difficult to accurately characterize advocacy activities. Drawing from extant research, the Advocacy Activities Scale was developed to assess three domains of parent advocacy: advocacy for one’s own children, advocacy for other families, and advocacy for systemic change. Factor analyses were conducted using data from two projects reflecting 382 parents of individuals with IDD from seven states and the District of Columbia. The scale confirmed the three moderately correlated domains of parent advocacy and demonstrated that the scale has high: reliability, validity, test-retest reliability, and moderate correlations with related measures.
Investigating workplace bullying (WPB), intention to quit and depression among nurses in the Upper West Region of Ghana
Authors: Dapilah Emmanuel , Druye Andrews Adjei 
Published: November 2024

Background
Intention to quit among nurses is increasingly recognized as a serious predictor of voluntary turnover. Voluntary turnover on the other hand is a significant factor fueling the shortage of nurses globally which could partly be blamed on negative workplace behaviors including but not limited to workplace bullying. Even though the relationship between workplace bullying and the intention to quit has been studied extensively, little is known about these concepts among nurses in Ghana.

Aim
The purpose of this study was to establish the relationship between workplace bullying among nurses and their intention to quit the profession in the Upper West Region of Ghana. We also determined the relationship between workplace bullying and depression among nurses.

Methods
We employed a cross-sectional design with 323 nurses recruited through a multistage sampling technique. Data were collected using a structured questionnaire with a 98.5% (N = 318) response rate.

Results
Initial descriptive statistics indicate that 64.4% (n = 203) of the nurses had intentions of quitting the job while 52.1% (n = 164) were depressed at various degrees based on scores on the DASS-21. Further analysis shows a positive linear relationship between WPB and intentions to quit. WPB was also correlated positively with depression among the nurses. This implies that an increased incidence of bullying at work is associated with increased intention to quit and depression among the nurses.

Conclusions
With over 50% of the nurses in this study intending to quit their jobs, it would be incumbent on nurse managers and other leaders at these health facilities to reconsider the work environment, policies, and leadership to prevent actual voluntary turnover. Managers must also fashion pragmatic strategies aimed at reducing stress and promoting the health and well-being of the nurses.
Risk factors for nosocomial infection in patients undergoing extracorporeal membrane oxygenation support treatment: A systematic review and meta-analysis
Authors: Lv Xiangui , Han Yan , Liu Daiqiang , Chen Xinwei , Chen Lvlin , Huang Huang , Huang Chao 
Published: November 2024

Objective
To evaluate the risk factors of nosocomial infection during Extracorporeal membrane oxygenation (ECMO) treatment through systematic evaluation and meta-analysis, in order to provide evidence-based basis for clinical treatment and prevention of nosocomial infection during ECMO treatment.

Method
Computer search of Cochrane Library, PubMed, Embase, and Web of Science databases was conducted to establish a database of relevant literature published in March 2023. Two researchers independently screened literature, extracted data, and evaluated quality based on inclusion and exclusion criteria, and then analyzed the data using STATA 14.0 software. This plan is registered with PROSPERO as CRD42021271083.

Result
A total of 2955 ECMO patients, including 933 nosocomial infected patients, were included in 23 articles. Meta analysis showed that immunosuppression, Heart transplantation, VA-ECMO, CRRT, red blood cell input, ECMO support time, mechanical ventilation time, ICU hospitalization time, and total hospitalization time were the risk factors for nosocomial infection in patients supported by ECMO.

Conclusion
ECMO treatment for nosocomial infections in patients is related to multiple factors. In clinical work, medical staff should identify high-risk groups of ECMO nosocomial infections, actively take preventive measures, and reduce the incidence and mortality of nosocomial infections.
Number of antenatal care utilization and associated factors among pregnant women in rural Ethiopia: Zero-inflated Poisson regression of 2019 intermediate Ethiopian Demography Health Survey
Authors: Geremew Bisrat Misganaw , Mariye Yitbarek Fantahun , Belay Daniel Gashaneh , Endale Hiwot Tezera , Gebreegziabher Fana Kinfe , Negash Habtu Kifle 
Published: November 2024

Background
About 70% of maternal fatalities (202,000) occurred in Sub-Saharan Africa alone. ANC lowers the morbidity and death rates for mothers and perinatals. The study aimed to determine the number of antenatal care and associated factors in the rural part of Ethiopia.

Methods
We performed secondary data analysis for the 2019 intermediate EDHS, utilizing weighted data from a total of 2896.7 pregnant women. A zero-inflated Poisson regression analysis was executed using Stata version 17.0. Using the incident rate ratio and odds ratio with a 95% confidence interval, the intensity of the link and direction were shown.

Result
From the weighted pregnant women, 1086(37.47%) used four or more antenatal care during the current pregnancy. About 848 (29.29%) women do not attend antenatal care during pregnancy. The highest percentage (29.65%) of antenatal care visits was observed from 25 to 29 age. In comparison to women without formal education, the frequency of prenatal visits was 1.1(IRR = 1.1, 95% CI: 1.0425, 1.175) and 1.2 (IRR = 1.2, 95% CI: 1.093, 1.308) times higher among women enrolled in primary, and secondary & above education, respectively. Orthodox followers had 13% (IRR = 0.87, 95% CI: .813, 0.935) and 31% (IRR = 0.69, 95% CI: .552, 0.870) times more prenatal care visits than Protestant and other religions’ followers, respectively. Prenatal care was substantially more common among women living in wealthy households (IRR = 1.12, 95% CI: 1.051, 1.189). In the zero-inflated model, educational status, household wealth index, region, and religion show significant association with antenatal care service utilization uptake becomes zero.

Conclusion
In rural Ethiopia, the rate of antenatal care service utilization has been lower than the respective current national statistics. A significant proportion of mothers who received antenatal care did not receive enough visits. Living in developing regions, following the Orthodox faith, being educated, and having a better home wealth position reduces the likelihood of skipping antenatal treatment.