bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time series forecasting of stock market index based on ENWMPCA model
Authors: Guo Zhiqiang , Wang Xiao , Zeng Yali , Yang Jie 
Published: July 2019

Abstract
Aiming at the high dimension of factors affecting the stock market index, and the problem that MPCA algorithm cannot distinguish the contribution of different eigenvectors to financial time series forecasting, eigenvalue normalization weighted multilinear principal component analysis (ENW-MPCA) is put forward. Due to the existence of correlation between stock markets, 34 technical indexes of 7 stock markets are selected to construct a three-dimensional tensor model. Eigenvectors of different eigenvalues have different contributions to the prediction accuracy of MPCA algorithm, thus adopt ENW-MPCA algorithm for the feature extraction, which can distinguish the different contribution of eigenvectors corresponding to different eigenvalues to the prediction while reducing dimension. Then using support vector machine for regression prediction, the prediction value of financial time series is obtained. Experimental results on the Hang Seng Index shows that, compared with the MPCA, the forecasting error of ENW-MPCA is smaller and the prediction accuracy is improved to a certain extent. This indicates that the proposed algorithm can fully retain the internal structure of stock time series, proving its validity and practicability.
Research on the Innovation and Application of Computer Communication Technology in Public Management
Authors: Chen Jiaxiong 
Published: July 2019

Abstract
Computer technology promotes the development of big data, and big data provides support for the development of computer technology. These provide a solid foundation for the wisdom of public management and are also widely used in various fields of society. However, issues such as information sharing barriers also affect the quality and level of public management and need to be improved. This paper analyzes the current situation of digital public management in China, as well as the impact of big data on public management, and proposes suggestions for the wisdom of public management.
A Meter-Bus Master Station Interface Circuit Based on Transistor Amplification Characteristics
Authors: Cheng-ying Yang , Yong Chen 
Published: July 2019

Abstract
This paper introduces a new Meter-Bus master station interface circuit based on a single power supply. By utilizing the switching characteristics and amplification characteristics of the triode, the level signal conversion and signal transmission are realized by fully combining the cut-off region of the triode to work, the linear amplification of the amplification region, and the low-voltage differential conduction of the saturation region. The M-bus master circuit of the prior art solution is usually constructed with many separate components, and the whole circuit also needs positive and negative dual power supplies, so the circuit is very complicated, the circuit failure rate is high, and the cost of the circuit is also high. The circuit described in this paper solves the above technical problems of the current Meter-BUS master circuit.
Study on wake effect of series fans
Authors: Zhang Zhi-yang , Hu Rong , Wei Min , Zhang Li-xin , Shi Ning-qiang , Zhang Xin-wang 
Published: July 2019

Abstract
Within the range of finite land resources, in order to improve the power generation efficiency of wind farms and reduce the impact of wake effects on the output power of fans, the rationality of wind farm fan layout is very important. The wake velocity and output power of two 2.5MW experimental fans in series 5D spacing are obtained by means of Doppler measured anemometer of windcube2. Based on CFX numerical simulation method, the simulation of the wake field is carried out by ANSYS software. The results showed that the fan spacing of 5D, the simulation and experimental results were basically the same. As the axial distance increased, the axial velocity first decreased and then increased, gradually recovered the incoming wind speed. The radial velocity and the tangential velocity amplitude and frequency fluctuation of different sections at the same angle were gradually reduced. The amplitude and frequency fluctuation of the tangential velocity were the largest at 3D, and were the minimum at 8D. The amplitude and frequency fluctuation of the radial velocity were the largest at 5D, and were the minimum at 3D. The velocity at the center of the bub gradually increased, and the velocity variation was the most obvious at 3D. The simulation speed first appeared an upward trend. Due to the superposition of the upstream fan wake, the output power of the downstream fan was greatly affected. Therefore, in the actual planning of the wind farm, the downstream fan should not be completely arranged in the wake field of the upstream fan.
Group size and social status affect scent marking in dispersing female meerkats
Authors: Morales-González Ana , Ruíz-Villar Héctor , Ozgul Arpat , Maag Nino , Cozzi Gabriele 
Published: July 2019

Abstract
Many animal species use scent marks such as feces, urine, and glandular secretions to find mates, advertise their reproductive status, and defend an exclusive territory. Scent marking may be particularly important during dispersal, when individuals emigrate from their natal territory searching for mates and a new territory to settle and reproduce. In this study, we investigated the scent-marking behavior of 30 dispersing female meerkats (Suricata suricatta) during the three consecutive stages of dispersal—emigration, transience, and settlement. We expected marking patterns to differ between dispersal stages, depending on social circumstances such as presence of unrelated mates and social status of the individuals within each dispersing coalition and also to be influenced by water and food availability. We showed that defecation probability increased with group size during the settlement stage, when newly formed groups are expected to signal their presence to other resident groups. Urination probability was higher in subordinate than in dominant individuals during each of the three dispersal stages and it decreased overall as the dispersal process progressed. Urine may, thus, be linked to advertisement of the social status within a coalition. Anal marking probability did not change across dispersal stages but increased with the presence of unrelated males and was higher in dominants than in subordinates. We did not detect any effect of rain or foraging success on defecation and urination probability. Our results suggest that feces, urine, and anal markings serve different communication purposes (e.g., within and between-group communication) during the dispersal process.
Histone methyltransferase SETDB1 promotes colorectal cancer proliferation through the STAT1-CCND1/CDK6 axis
Authors: Yu Lu , Ye Feng , Li Yi-Yi , Zhan Yi-Zhi , Liu Yang , Yan Hong-Mei , Fang Yuan , Xie Yu-Wen , Zhang Feng-Jiao , Chen Long-Hua , Ding Yi , Chen Ke-Li 
Published: July 2019

Abstract
Upregulation of histone methyltransferase SET domain bifurcated 1 (SETDB1) is associated with poor prognosis in cancer patients. However, the mechanism of oncogenicity of SETDB1 in cancer is hitherto unknown. Here, we show that SETDB1 is upregulated in human colorectal cancer (CRC) where its level correlates with poor clinical outcome. Ectopic SETDB1 promotes CRC cell proliferation, whereas SETDB1 attenuation inhibits this process. Flow cytometry reveals that SETDB1 promotes proliferation by driving the CRC cell cycle from G0/G1 phase to S phase. Mechanistically, SETDB1 binds directly to the STAT1 promoter region resulting in increased STAT1 expression. Functional characterization reveals that STAT1-CCND1/CDK6 axis is a downstream effector of SETDB1-mediated CRC cell proliferation. Furthermore, SETDB1 upregulation is sufficient to accelerate in vivo proliferation in xenograft animal model. Taken together, our results provide insight into the upregulation of SETDB1 within CRC and can lead to novel treatment strategies targeting this cell proliferation-promoting gene.
On Measles, Vaccination, Social Media Activism, and How to Win Back Our Role as Our Patients’ Best Advocates
Authors: Oehler Richard L 
Published: July 2019

Abstract
Once declared transmission free in the United States less than 20 years ago, measles and other vaccine-preventable diseases have made a spectacular comeback. Waning public support for childhood immunization and subsequent recent outbreaks of vaccine-preventable diseases have been spawned by several technological and social factors, including the erosion of the provider-patient relationship, the emergence of internet-based patient resources and social media sites, and the rise of online healthcare activism. New tools are needed for physicians and healthcare providers to reverse this trend and regain our role as our patients’ best advocates.
Cardiovascular long-term outcome and prophylactic treatment patterns in peripheral arterial disease in a population-based cohort
Authors: Sartipy Fredrik , Lundin Fredrik , Wahlberg Eric , Sigvant Birgitta 
Published: July 2019

Abstract

Aims
This study evaluates 10-year follow-up data on associated comorbidity, mortality, and pharmacological treatment patterns for men and women with different stages of peripheral arterial disease (PAD) in a population-based setting.

Methods and results
This was a prospective observational population-based cohort study, based on physical examinations and questionnaires at baseline supplemented with national register data between 2005 and 2015. Subjects were placed in subgroups defined by ankle–brachial index levels and reported symptoms; asymptomatic PAD (APAD), intermittent claudication (IC), severe limb ischaemia (SLI), or references (Ref). Cox proportional hazards regression models were used for analysis with adjustments for sex and baseline age and comorbidity. The cohort consisted of 5080 subjects (45% males). At baseline, APAD, IC, and SLI were prevalent in 559 (11%), 320 (6.3%), and 78 (1.5%) subjects, respectively. A significant increased risk for cardiovascular (CV) death, even when adjusted for age and baseline morbidity, were noted in all PAD stages as compared with reference group with a small difference between APAD and IC, an adjusted hazard ratio 1.80 (confidence interval 1.45–2.22) and 1.95 (1.50–2.53), respectively. Only about 60% of PAD subjects received medical prophylactic treatment as recommended in guidelines.

Conclusion
Peripheral arterial disease subjects had significantly increased CV morbidity and mortality risks, especially males. Asymptomatic PAD subjects confer similar risk for CV events as symptomatic patients. Our findings motivate enhanced preventive efforts of all PAD stages, including in asymptomatic disease.
Molecular typing of Streptococcus agalactiae isolates of serotype Ia from tilapia in southern China
Authors: Su Youlu , Liu Chan , Deng Yiqin , Cheng Changhong , Ma Hongling , Guo Zhixun , Feng Juan 
Published: July 2019

ABSTRACT
Streptococcus agalactiae is an important pathogen of tilapia causing enormous economic losses worldwide. In this study, multilocus sequence typing indicated that 75 S. agalactiae isolates from tilapia in southern China belonged to sequence type-7, as well as belonging to serotype Ia, as confirmed by multiplex PCR assay. The putative-virulence gene profiles and genetic variation of these strains were determined by three sets of multiplex PCR and multi-virulence locus sequencing typing (MVLST), respectively. Analysis of putative-virulence gene profiles showed that each strain harbored 18 putative-virulence genes but lacked lmb and scpB. Three putative-virulence genes (srr-1, bibA and fbsA) were further selected for MVLST analysis. Our data showed that the strains had 14 MVLST types (1–14) and clustered in three groups (Groups I–Ⅲ). The period of time during 2013 and 2014 was an important turning point for the differentiation of the putative-virulence genes of S. agalactiae, as type 1 within Group Ⅱ became the predominant MVLST type. There were significant differences in MVLST types of S. agalactiae isolated from different tilapia farming regions. MVLST assay may improve the discriminatory power and is suitable for understanding the epidemiology of S. agalactiae serotype Ia and screening multivalent vaccine candidate strains.
A gene regulatory network explains RET–EDNRB epistasis in Hirschsprung disease
Authors: Chatterjee Sumantra , Chakravarti Aravinda 
Published: July 2019

AbstractDisruptions in gene regulatory networks (GRNs), driven by multiple deleterious variants, potentially underlie complex traits and diseases. Hirschsprung disease (HSCR), a multifactorial disorder of enteric nervous system (ENS) development, is associated with at least 24 genes and seven chromosomal loci, with RET and EDNRB as its major genes. We previously demonstrated that RET transcription in the ENS is controlled by an extensive GRN involving the transcription factors (TFs) RARB, GATA2 and SOX10 and other HSCR genes. We now demonstrate, using human and mouse cellular and animal models, that EDNRB is transcriptionally regulated in the ENS by GATA2, SOX10 and NKX2.5 TFs. Significantly, RET and EDNRB expression is regulated by their shared use of GATA2 and SOX10, and in turn, these TFs are controlled by EDNRB and RET in a dose-dependent manner. This study expands the ENS development GRN to include both RET and EDNRB, uncovers the mechanistic basis for RET–EDNRB epistasis and emphasizes how functionally different genes associated with a complex disorder can be united through a common GRN.
Long-term firm growth: an empirical analysis of US manufacturers 1959–2015
Authors: Dosi Giovanni , Grazzi Marco , Moschella Daniele , Pisano Gary , Tamagni Federico 
Published: July 2019

Abstract
Firm growth is an essential feature of market economies, shaping together macroeconomic performance and the evolution of industry structures. As a potential indicator of organizational “fitness” within a competitive environment, firm growth is also a central concern to both the practice and theory of business strategy. Despite both its theoretical and practical importance, though, growth remains a poorly understood property of firms. While previous studies have documented the fat-tailed nature of firm growth rates, we know far less about the patterns of growth rates over long periods of time. For instance, do “fast growers” tend to maintain their relative growth rates advantages over long periods or is superior growth a transitory phenomenon? Is, as predicted by evolutionary and capability-based theories of the firm, the process of firm growth path-dependent or is it more akin to a random walk? The answers to these questions are central to building a robust theory of firm growth. This article attempts to address this gap in our empirical knowledge of firm growth using a dataset that spans 50 years, which allows the abandonment of the assumption, common to all incumbent studies, that the stochastic paths of all firms stem from the same generating process. These exploratory results indicate that growth rate persistence is there and may be even substantial for some firms, but it is rare. We also study the links between the micro-properties of firm growth within sectors and the patterns of aggregate growth of these same sectors. Indeed, we find circumstantial but widespread evidence that heterogeneity across firms correlates with industry dynamism.
Mediastinal liposarcoma: a rare visceral mediastinal tumour
Authors: Krishnasamy Sivakumar , Krishna Nair Ashvin , Hashim Shahrul Amry , Raja Mokhtar Raja Amin 
Published: July 2019

Abstract
Liposarcoma is the second most common type of soft tissue malignancy in adults. They are malignant tumours with a mesenchymal origin. Mediastinal liposarcoma accounts for <1% of mediastinal tumours and 2% of liposarcoma. We report a patient with mediastinal liposarcoma who presented with cardiac tamponade, 25 years after the initial liposarcoma in the popliteal fossa.
The current scope of healthcare-associated infection surveillance activities in hospitalized immunocompromised patients: a systematic review
Authors: Valentine Jake C , Hall Lisa , Verspoor Karin M , Worth Leon J 
Published: July 2019

Abstract

Background
Immunocompromised patients are at increased risk of acquiring healthcare-associated infections (HAIs) and often require specialized models of care. Surveillance of HAIs is essential for effective infection-prevention programmes. However, little is known regarding standardized or specific surveillance methods currently employed for high-risk hospitalized patients.

Methods
A systematic review adopting a narrative synthesis approach of published material between 1 January 2000 and 31 March 2018 was conducted. Publications describing the application of traditional and/or electronic surveillance of HAIs in immunocompromised patient settings were identified from the Ovid MEDLINE®, Ovid Embase® and Elsevier Scopus® search engines [PROSPERO international prospective register of systematic reviews (registration ID: CRD42018093651)].

Results
In total, 2708 studies were screened, of whom 17 fulfilled inclusion criteria. Inpatients diagnosed with haematological malignancies were the most-represented immunosuppressed population. The majority of studies described manual HAI surveillance utilizing internationally accepted definitions for infection. Chart review of diagnostic and pathology reports was most commonly employed for case ascertainment. Data linkage of disparate datasets was performed in two studies. The most frequently monitored infections were bloodstream infections and invasive fungal disease. No surveillance programmes applied risk adjustment for reporting surveillance outcomes.

Conclusions
Targeted, tailored monitoring of HAIs in high-risk immunocompromised settings is infrequently reported in current hospital surveillance programmes. Standardized surveillance frameworks, including risk adjustment and timely data dissemination, are required to adequately support infection-prevention programmes in these populations.
Happy Mother’s Day? Maternal and neonatal mortality and morbidity in low- and middle-income countries
Authors: van den Broek Nynke 
Published: July 2019

Abstract
At least 800 women die each day during pregnancy or birth and more than 15 000 babies each day are stillborn or die in the first month of life. Almost all of these deaths occur in low- and middle-income countries. Many more women and babies are known to suffer morbidity as a result of pregnancy and childbirth. However, reliable estimates of the burden of physical, psychological and social morbidity and comorbidity during and after pregnancy are not available. Although there is no single intervention or ‘magic bullet’ that would reduce mortality and improve health, there are evidence-based care packages which are defined and agreed internationally. A functioning health system with care available and accessible for everyone at all times is required to ensure women and babies survive and thrive.
Are the Contents of International Treaties Copied and Pasted? Evidence from Preferential Trade Agreements
Authors: Allee Todd , Elsig Manfred 
Published: July 2019

AbstractMost accounts of international negotiations suggest that global agreements are individually crafted and distinct, while some emerging scholarship suggests a heavy reliance on models and templates. In this research, we present a comprehensive test of whether new international treaties are heavily copied and pasted from past ones. We specify several reasons to expect widespread copying and pasting, and argue that both the most and least powerful countries should be most likely to do so. Using text analysis to examine several hundred preferential trade agreements (PTAs), we reveal that most PTAs copy a sizable majority of their content word for word from an earlier agreement. At least one hundred PTAs take 80 percent or more of their contents directly from a single, existing treaty—with many copying and pasting 95 percent or more. These numbers climb even higher when we compare important substantive chapters of trade agreements, many of which are copied and pasted verbatim. Such copying and pasting is most prevalent among low-capacity governments that lean heavily on existing templates, and powerful states that desire to spread their preferred rules globally. This widespread replication of existing treaty language reshapes how we think about international cooperation, and it has important implications for literatures on institutional design, policy diffusion, state power, and legal fragmentation.
Forming Pop III binaries in self-gravitating discs: how to keep the orbital angular momentum
Authors: Chon Sunmyon , Hosokawa Takashi 
Published: July 2019

ABSTRACT
The disc fragmentation is a possible process leading to the formation of Population III stellar binary systems. However, numerical simulations show diverse fates of the fragments; some evolve into stable binaries and others merge away with a central star. To clarify the physics behind such diversity, we perform a series of 3D hydrodynamics simulations in a controlled manner. We insert a point particle mimicking a fragment in a self-gravitating disc, where the initial mass and position are free parameters, and follow the orbital evolution for several tens of orbits. The results show great diversity even with such simple experiments. Some particles shortly merge away after migrating inward, but others survive as the migration stalls with the gap opening in the disc. We find that our results are well interpreted postulating that the orbital angular momentum is extracted by (i) the gravitational torque from the disc spiral structure, and (ii) tidal disruption of a gravitationally bound envelope around the particle. Our analytic evaluations show the processes (i) and (ii) are effective in an outer and inner part of the disc, respectively. There is a window of the gap opening in the middle, if the envelope mass is sufficiently large. These all agree with our numerical results. We further show that the binaries, which appear for the ‘survival’ cases, gradually expand while accreting the disc gas. Our theoretical framework is freely scalable to be applied for the present-day star and planet formation.
Planetary system detection by estimating the covariance of coronagraphic lucky images
Authors: Cagigas Miguel A , Cagigal Manuel P , Valle Pedro J , Canales Vidal F , Fuentes Antonio , López Roberto 
Published: July 2019

ABSTRACT
In this paper, we review two different methods to increase image contrast and propose the combination of both to detect faint companions surrounding a host star. Coronagraphy allows us to block light coming from the host star so that the residual star light can be reduced by several orders of magnitude. On the other hand, estimating the Covariance of Lucky Images (COELI) is a proven method to detect faint companions from ground-based telescope images. The dynamic range of the detection camera limits this technique. Hence, the application of COELI to coronagraphic images may increase the magnitude range of the detectable companions. COELI only requires the existence of a reference, which can be obtained using an existing stellar companion or using a coronagraphic mask designed to create a faint image of the host star. We provide an analysis of the combination of the techniques by processing coronagraphic images obtained by the William Herschel Telescope.