bluuebunny/crossref_metadata_2025_split huggingface dataset:
A differentially private method for crowdsourcing data submission
Authors: Zhang Lefeng , Xiong Ping , Ren Wei , Zhu Tianqing 
Published: December 2018

SummaryIn recent years, the ubiquity of mobile devices has made spatial crowdsourcing a successful business platform for conducting spatiotemporal projects. In spatial crowdsourcing, workers contribute to a project by performing a task at a specific location. However, these platforms present serious threats to people's location privacy because sensitive information may be leaked from submitted spatiotemporal data. As a result, people may be hesitant to join spatial crowdsourcing projects, which hampers further applications of this business model. In this paper, we propose a private spatial crowdsourcing data submission algorithm, called PS‐Sub. This is a differentially private method that preserves people's location privacy and provides acceptable data utility. Rigorous privacy analyses theoretically demonstrate the privacy guarantees inherent in the proposed model. Experiments based on real‐world datasets were conducted using practical evaluation metrics. The results show that our method is able to achieve location privacy preservation efficiently, at an acceptable cost for spatial crowdsourcing applications.
Hollow Mesoporous Co3O4–CeO2 Composite Nanotubes with Open Ends for Efficient Catalytic CO Oxidation
Authors: He Jiaqin , Chen Dongyun , Li Najun , Xu Qingfeng , Li Hua , He Jinghui , Lu Jianmei 
Published: December 2018

AbstractCatalytic performance is heavily dependent on how the structures of nanomaterials are designed. Co3O4–CeO2 composite nanotubes with open ends and mesoporous structures were fabricated through a facile and environmentally friendly reaction. The mesoporous Co3O4 nanotubes were synthesized by the calcination of cobalt–aspartic acid (Co–Asp) nanowires and coated with a CeO2 shell. The composite nanotubes were characterized by SEM, TEM, XRD, and X‐ray photoelectron spectroscopy. The composite materials comprise a combination of Co3O4 nanotubes and CeO2 nanoparticles with a hollow and mesoporous bimetallic oxide structure. The large BET surface area led to a higher degree of accessible active sites compared with other Co3O4–CeO2 composite nanomaterials with other structures. The resulting Co3O4–CeO2‐26.3 wt % composite nanotubes, with a CeO2 content of approximately 26.3 wt %, achieved 100 % CO conversion at 145 °C. Additionally, the synergistic effect between the two metal oxides comprising the Co3O4–CeO2 composite nanotubes was demonstrated by the enhanced catalytic activity compared with pure Co3O4 nanotubes and CeO2 nanoparticles.
Highly Porous Hypercrosslinked Polymers Derived from Biobased Molecules
Authors: Björnerbäck Fredrik , Hedin Niklas 
Published: December 2018

AbstractHighly porous and hyper‐cross‐linked polymers (HCPs) have a range of applications and are typically synthesized in an unsustainable manner. Herein, HCPs were synthesized from abundant biobased or biorelated compounds in sulfolane with iron(III) chloride as Lewis acid catalyst. As reactants, quercetin, tannic acid, phenol, 1,4‐dimethoxybenzene, glucose, and a commercial bark extract were used. The HCPs had high CO2 uptake (up to 3.94 mmol g−1 at 0 °C and 1 bar), total pore volumes (up to 1.86 cm3 g−1), and specific surface areas (up to 1440 m2 g−1). 1H NMR, 13C NMR, and IR spectroscopy, wide‐angle X‐ray scattering, elemental analysis, and SEM revealed, for example, that the HCPs consisted of amorphous and cross‐linked aromatic and phenolic structures with significant contents of aliphatics, oxygen, and sulfur.
Parasympathetic regulation in cognitive and emotional challenge contexts differentially predicts specific aspects of children’s emotional functioning
Authors: Quiñones‐Camacho Laura E. , Davis Elizabeth L. 
Published: December 2018

AbstractParasympathetic regulation has been consistently linked with better emotional functioning in childhood, but it is still not clear if parasympathetic regulation serves as a transcontextual marker of adaptive emotional functioning or if this link is context‐specific. This study tested this by examining the specificity of the relation between parasympathetic regulation in distinct types of challenge tasks and different aspects of children’s emotional functioning. Emotional functioning included parent‐reported emotional reactivity, parent‐reported general emotion regulation ability, and child‐reported emotion regulation strategy knowledge. One hundred and forty‐four 4‐ to 9‐year‐olds (M = 6.88 years; SD = 1.80; 52% girls) participated in a cognitive (inhibitory control) and two discrete emotional (disappointing, fear‐eliciting) challenges. Resting and reactive indices of respiratory sinus arrhythmia quantified parasympathetic regulation. Emotional reactivity was predicted by parasympathetic regulation during the cognitive challenge, general emotion regulation was predicted by regulation during the fear‐eliciting task, and emotion regulation strategy knowledge was predicted by regulation during the disappointment task. Results highlight the importance of considering task context in investigations of how parasympathetic regulation relates to children’s functioning.
Recollections of positive early caregiving relate to sympathetic nervous system activation and chronic inflammation in subsequent generations
Authors: Lyons Emma R. , Norman Wells Jessica , Scholtes Carolyn M. , Mintz Brianna , Giuliano Ryan J. , Skowron Elizabeth A. 
Published: December 2018

AbstractTo understand links between early experience and biomarkers of peripheral physiology in adulthood, this study examined associations between quality of early caregiving and markers of sympathetic activation and chronic inflammation in a sample of 52 low‐income mothers and their preschool‐aged children. Mothers reported on levels of positive caregiving experienced during childhood using the Structural Analysis of Social Behavior‐Intrex. Mother and child sympathetic activation was indexed via pre‐ejection period (PEP) at rest, during a dyadic social engagement task, and for children, while interacting with an unfamiliar adult. C‐reactive protein (CRP) was collected using whole blood spots to assess levels of low‐grade chronic inflammation. Results showed that mothers who reported experiencing more warm guidance and support for autonomy in early childhood displayed lower resting sympathetic nervous system activation (i.e., longer PEP) and lower chronic inflammation (i.e., CRP levels). Further, lower maternal chronic inflammation levels were associated with lower sympathetic activation (i.e., longer PEP) in their children at rest, and during social interactions with mother and a female stranger.
Bidirectional mitochondrial introgression between Korean cobitid fish mediated by hybridogenetic hybrids
Authors: Kwan Ye‐Seul , Ko Myeong‐Hun , Jeon Yeon‐Seon , Kim Hyo‐Jin , Won Yong‐Jin 
Published: December 2018

AbstractGenomic introgression through interspecific hybridization has been observed in some species of the freshwater fish family Cobitidae. Within this family, a Cobitis hankugensis–Iksookimia longicorpa diploid–triploid hybrid species complex on the Korean peninsula is unique in displaying hybridogenesis, a unisexual reproduction mode that allows hybrids to mediate the transfer of mitochondrial DNA (but not nuclear DNA) between the two parent species. However, populations of the parental species in the wild have never been examined for the potential effect of introgression on their genomes. To address the genetic consequences of unisexual hybridization on the parental species, we examined genetic structure of the two parental species, C. hankugensis and I. longicorpa, in three independent natural habitats where they coexist with their hybrid complex using DNA sequence data of one mitochondrial gene and three nuclear genes. We found that mitochondrial introgression between the two species was extensive in all the examined localities, while there was no evidence of nuclear introgression across the species boundary. This result indicates that the hybridogenetic individuals mediate mitochondrial introgression from one species to the other, producing mito‐nuclear mosaic genomes such as C. hankugensis nuclear genomes associated with I. longicorpa mitochondrial DNA and the reverse. The direction and degree of introgression varied among the three localities, but the underlying mechanisms for this observation proved elusive. Introgression might depend on which species serves as the predominant sperm or ovum donor or the environmental conditions of the localities. The present study suggests that introgressive hybridization between pure C. hankugensis and I. longicorpa species is highly likely where the two species co‐occur with hybridogenetic individuals, but the consequence of introgression could be variable due to the history and environmental characteristics of particular populations across the parental species’ ranges.
Oxidative addition of (RO)2P(O)H to Pt(0) complexes generating Pt‐H complexes: P(O)‐H bond cleavage vs P(O‐H) bond cleavage
Authors: Chen Tieqiao , Han Li‐Biao 
Published: December 2018

Abstract(MeO)2P(O)H oxidatively added to Pt(PCy3)2 quickly, at the beginning, generating cis‐Pt‐H[P(O)(OMe)2](PCy3)2 predominately, which gradually isomerized to trans‐Pt‐H[P(O)(OMe)2](PCy3)2. In contrast, a (MeO)2P(OH)‐coordinated Pt complex in situ generated only produced trans‐Pt‐H[P(O)(OMe)2](PCy3)2. These results showed that the P(O)‐H bond perhaps directly adds to Pt(0) complex (P(O)‐H cleavage) forming Pt‐H complexes, rather than by an alternative coordination of (MeO)2P(OH) to Pt(0) followed by an O‐H cleavage path.
Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta‐analysis
Authors: Di Maio Pasquale , Iocca Oreste , De Virgilio Armando , Ferreli Fabio , Cristalli Giovanni , Pellini Raul , Golusinski Pawel , Ricci Giampietro , Spriano Giuseppe 
Published: December 2018

AbstractBackgroundThis systematic review and meta‐analysis aims to evaluate the effectiveness of palatine tonsillectomy in patients with cervical metastasis from squamous cell carcinoma of unknown primary (SCCUP) origin.MethodsA systematic review including studies that encompassed palatine tonsillectomy in the SSCUP diagnostic evaluation was conducted. A single arm meta‐analysis was then made to obtain the overall identification rate of tonsillectomy.ResultsFourteen studies were included, comprising 673 patients who underwent 416 palatine tonsillectomies, 338 preformed during examination under anesthesia (EUA) and 78 managed with transoral robotic surgery (TORS). A total of 140 occult tonsillar malignancies were identified; of these, 124 (89%) were ipsilateral, 2 (1%) contralateral, and 14 (10%) synchronous bilateral. Meta‐analysis of 11 studies showed an overall detection rate of tonsillectomy of 0.34 (99% confidence interval 0.23‐0.46).ConclusionPalatine tonsillectomy is a valuable diagnostic tool in the management of patients with head and neck SCCUP. Bilaterality of tonsillectomy should be taken into consideration.
Colloid transport and distribution in the hyporheic zone
Authors: Jin Guangqiu , Zhang Zhongtian , Tang Hongwu , Xiaoquan Yang , Li Ling , Barry David Andrew 
Published: December 2018

AbstractColloids moving from the stream into the hyporheic zone may have a negative impact on aquatic ecosystems as they are potential contaminants or carriers of contaminants. Moreover, retained colloids in the hyporheic zone could not only reduce the exchange flux between the stream and streambed but also change the conditions of the bed, affecting the habitats for aquatic organisms. Previous studies focused on the exchange flux across the sediment–water interface, but the colloid transport processes and distribution of retained colloids in the streambed have received little attention. We conducted experiments within a laboratory flume to examine these processes in a streambed driven by bedform‐induced hyporheic flow. Retained colloids measured in the bed at the end of the experiments revealed colloid retention mainly in the shallow layer of hyporheic zone (0–5 cm below the interface). The results demonstrated significant effects of particle trapping and settling on the colloid transport and distribution in the streambed. Retention leads to the formation of a colloid‐filled shallow layer in the bed. Particle paths based on model simulations showed that colloid settling in pore water modifies the direction of colloid transport and allows the colloid particles to move more deeply in the bed.
A survey of opinion and practice regarding prenatal diagnosis of vasa previa among obstetricians from Australia and New Zealand
Authors: Javid Nasrin , Hyett Jonathan A. , Walker Susan P. , Sullivan Elizabeth A. , Homer Caroline S.E. 
Published: December 2018

AbstractObjectivesTo define current obstetric opinion and clinical practice regarding the prenatal diagnosis of vasa previa in Australia and New Zealand.MethodsA population‐based cross‐sectional survey of Fellows of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists was conducted from April to May, 2016. Descriptive analysis was used to define factors influencing opinion and practice regarding definition of vasa previa, attributable risk factors, and the value of screening.ResultsOverall, 453 respondents were included in the study. Two‐thirds (304/453; 67.1%) defined vasa previa as exposed fetal vessel(s) running over or within 2 cm of the internal os. A higher proportion of ultrasound specialists (30/65; 46.2%) preferred a broader definition as compared with generalists (115/388; 29.6%; P<0.001). Overall, Fellows were supportive (342/430; 79.5%) of both reporting ultrasound‐based risk factors at the 20‐week anomaly scan and targeted screening (298/430; 69.3%). Only 77/453 (17.0%) respondents recognized all five “known” risk factors for vasa previa.ConclusionsThere was a lack of consensus regarding the definition and diagnosis process for vasa previa. There was also a knowledge gap in risk factors for vasa previa that would inform a targeted screening policy. Nevertheless, support for targeted screening was strong from obstetricians who responded.
Silica/polycaprolactone nanofiber scaffold variants for human periosteal cell growth
Authors: Burton Christopher W. , DiFeo Childs Robin , McClellan Phillip , Yu Qing , Bundy Joshua , Gao Min , Evans Edward , Landis William 
Published: December 2018

AbstractPolycaprolactone (PCL) nanofiber scaffolds with attached cadaveric human periosteum or its cells were investigated in this study as a tissue‐engineering approach to repair nonunion injuries of bone. Addition of silica nanoparticles (silica or nSiO2) to PCL scaffolds was examined for effects on the growth of human periosteal cells in vitro and in vivo. Electrospun PCL nanofiber (nanoPCL) scaffolds were fabricated with different silica contents (0, 0.5, and 1.0 wt %) and utilized as substrates on which periosteal cells were seeded. Human periosteal cell growth analyzed in vitro over 21 days with a PrestoBlue viability assay increased as a function of culture time on each of the three different silica/nanoPCL scaffolds. Cadaveric periosteum attached to nanoPCL scaffolds with or without silica was wrapped around allograft bone and implanted for 10 or 20 weeks in athymic (nude) mice. Histological and immunohistochemical analyses of these experiments in vivo confirmed the presence of viable cells populating the constructs after their retrieval from host mice. Osterix, a marker for osteoblasts, increased in retrieved constructs over time and indicated remodeling of the underlying allograft bone. Summary results suggest that silica/nanoPCL scaffolds may be utilized as substrates for periosteal cell and tissue expansion to augment and support clinical applications for treatment and healing of bone defects, including segmental bone injuries and nonunions. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 791–801, 2019.
Palyno‐anatomical studies of monocot taxa and its taxonomic implications using light and scanning electron microscopy
Authors: Bahadur Saraj , Ahmad Mushtaq , Zafar Muhammad , Sultana Shazia , Begum Najla , Ashfaq Shomaila , Gul Saba , Khan Muhammad Saleem , Shah Syed Nasar , Ullah Fazal , Saqib Saddam , Ayaz Asma 
Published: December 2018

AbstractPalyno‐anatomical study of monocots taxa using Light and Scanning Electron Microscopy (SEM) was first time conducted with a view to evaluating their taxonomic significance. Studied plants were collected from different eco‐climatic zones of Pakistan ranges from tropical, sub‐tropical, and moist habitats. The aim of this study is to use palyno‐anatomical features for the correct identification, systematic comparison, and investigation to elucidate the taxonomic significance of these features, which are useful to taxonomists for identifying monocot taxa. A signification variation was observed in quantitative and qualitative characters by using the standard protocol of light microscopy (LM) and SEM. Epidermal cell length varied from maximum inAllium griffthianum(480 ± 35.9) μm at the adaxial surface to minimum inCanna indica(33.6 ± 8.53) μm on abaxial surface. Maximum exine thickness was observed inCanna indica(4.46) μm and minimum inAllium grifthianum(0.8) μm. Variation was observed in shape and exine ornamentation of the pollen, shape of the epidermal cell, number, size, and type of stomata, guard cell shape, and anticlinal wall pattern. Based on these palyno‐anatomical features a taxonomic key was developed, which help in the discrimination of studied taxa. In conclusion, LM and SEM pollen and epidermal morphology is explanatory, significant, and can be of special interest for the plant taxonomist in the correct identification of monocots taxa.
Choosing Wisely campaigns globally: A shared approach to tackling the problem of overuse in healthcare
Authors: Born Karen B. , Levinson Wendy 
Published: December 2018

AbstractChoosing Wisely, a campaign which launched in the United States in 2012, has now spread to over 20 countries around the world. Choosing Wisely campaigns share a core set of principles, which inform how campaigns operate and engage with physicians, clinicians, patients, and other stakeholders. This article will address the origins and motivation of Choosing Wisely campaigns, and what factors have supported their spread. It will also discuss how leaders of Choosing Wisely campaigns are collaborating on shared priorities.
Clinical practice guidelines for IgG4‐related sclerosing cholangitis
Authors: Kamisawa Terumi , Nakazawa Takahiro , Tazuma Susumu , Zen Yoh , Tanaka Atsushi , Ohara Hirotaka , Muraki Takashi , Inui Kazuo , Inoue Dai , Nishino Takayoshi , Naitoh Itaru , Itoi Takao , Notohara Kenji , Kanno Atsushi , Kubota Kensuke , Hirano Kenji , Isayama Hiroyuki , Shimizu Kyoko , Tsuyuguchi Toshio , Shimosegawa Tooru , Kawa Shigeyuki , Chiba Tsutomu , Okazaki Kazuichi , Takikawa Hajime , Kimura Wataru , Unno Michiaki , Yoshida Masahiro 
Published: December 2018

AbstractIgG4‐related sclerosing cholangitis (IgG4‐SC) is a distinct type of cholangitis frequently associated with autoimmune pancreatitis and currently recognized as a biliary manifestation of IgG4‐related disease. Although clinical diagnostic criteria of IgG4‐SC were established in 2012, differential diagnosis from primary sclerosing cholangitis and cholangiocarcinoma is sometimes difficult. Furthermore, no practical guidelines for IgG4‐SC are available. Because the evidence level of most articles retrieved through searching the PubMed, Cochrane Library, and Igaku Chuo Zasshi databases was below C based on the systematic review evaluation system of clinical practice guidelines MINDS 2014, we developed consensus guidelines using the modified Delphi approach. Three committees (a guideline creating committee, an expert panelist committee for rating statements according to the modified Delphi method, and an evaluating committee) were organized. Eighteen clinical questions (CQs) with clinical statements were developed regarding diagnosis (14 CQs) and treatment (4 CQs). Recommendation levels for clinical statements were set using the modified Delphi approach. The guidelines explain methods for accurate diagnosis, and safe and appropriate treatment of IgG4‐SC.
M2b macrophage polarization and its roles in diseases
Authors: Wang Le-xun , Zhang Sheng-xi , Wu Hui-juan , Rong Xiang-lu , Guo Jiao 
Published: December 2018

Abstract
Macrophages play an important role in a wide variety of physiologic and pathologic processes. Plasticity and functional polarization are hallmarks of macrophages. Macrophages commonly exist in two distinct subsets: classically activated macrophages (M1) and alternatively activated macrophages (M2). M2b, a subtype of M2 macrophages, has attracted increasing attention over the past decade due to its strong immune-regulated and anti-inflammatory effects. A wide variety of stimuli and multiple factors modulate M2b macrophage polarization in vitro and in vivo. M2b macrophages possess both protective and pathogenic roles in various diseases. Understanding the mechanisms of M2b macrophage activation and the modulation of their polarization might provide a great perspective for the design of novel therapeutic strategies. The purpose of this review is to discuss current knowledge of M2b macrophage polarization, the roles of M2b macrophages in a variety of diseases and the stimuli to modulate M2b macrophage polarization.
NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation
Authors: Pontarini Elena , Lucchesi Davide , Fossati-Jimack Liliane , Coleby Rachel , Tentorio Paolo , Croia Cristina , Bombardieri Michele , Mavilio Domenico 
Published: December 2018

Abstract
Salivary glands (SGs) represent a permissive site for several sialotropic viruses whose persistence is linked to the development of autoimmunity. Natural Killer (NK) cells play a key role in viral clearance but their involvement in viral infection control and in tertiary lymphoid structures (TLS) development within SGs is unknown. By using an inducible model of TLS in the SGs of wild-type C57BL/6 mice, induced by the local delivery of a replication-defective adenovirus (AdV), we demonstrated that circulating NK cells are rapidly recruited to SGs and highly enrich the early inflammatory infiltrate prior to TLS development. NK cells migrating to SGs in response to AdV infection up-regulate NKp46, undergo proliferation, acquire cytotoxic potential, produce Granzyme-B and IFN-γ, and reduce viral load in the acute phase of the infection. Nonetheless, the selective depletion of both circulating and infiltrating NK cells in AdV-infected mice neither affect the development and frequency of TLS nor the onset of autoimmunity. These data demonstrate that, upon local viral delivery of AdV, peripheral NK cells homing to SGs can exert an early control of the viral infection but are dispensable for the formation of TLS and breach of immunologic tolerance.
The role of chlorine atom on the binding between 2‐phenyl‐1H‐benzimidazole analogues and fat mass and obesity‐associated protein
Authors: Li Junya , Wang Ying , Han Xinxin , Wang Ning , Yu Wenquan , Wang Ruiyong , Chang Junbiao 
Published: December 2018

AbstractIn this work, nine 2‐phenyl‐1H‐benzimidazole structural analogues were screened for potential inhibitor of the fat mass and obesity‐associated protein (FTO) by isothermal titration calorimetry (ITC). The results show that the binding between 6‐chloro‐2‐phenyl‐1H‐benzimidazole (1d) and FTO was dominated by entropy. Results of enzymatic activity assays provided an IC50 value of 24.65 μM for 1d. Our previous results and comparison of nine structural analogues indicated that the chlorine atom was crucial for the binding of small molecules with FTO. The identification of novel small molecules may provide information for the design of FTO inhibitors and the treatment of leukemia.