bluuebunny/crossref_metadata_2025_split huggingface dataset:
Slip distribution of the 2017 Mw6.6 Bodrum–Kos earthquake: resolving the ambiguity of fault geometry
Authors: Konca A Ozgun , Guvercin Sezim Ezgi , Ozarpaci Seda , Ozdemir Alpay , Funning Gareth J , Dogan Ugur , Ergintav Semih , Floyd Michael , Karabulut Hayrullah , Reilinger Robert 
Published: July 2019

SUMMARYThe 2017 July 20, Mw6.6 Bodrum–Kos earthquake occurred in the Gulf of Gökova in the SE Aegean, a region characterized by N–S extension in the backarc of the easternmost Hellenic Trench. The dip direction of the fault that ruptured during the earthquake has been a matter of controversy where both north- and south-dipping fault planes were used to model the coseismic slip in previous studies. Here, we use seismic (seismicity, main shock modelling, aftershock relocations and aftershock mechanisms using regional body and surface waves), geodetic (GPS, InSAR) and structural observations to estimate the location, and the dip direction of the fault that ruptured during the 2017 earthquake, and the relationship of this event to regional tectonics. We consider both dip directions and systematically search for the best-fitting locations for the north- and south-dipping fault planes. Comparing the best-fitting planes for both dip directions in terms of their misfit to the geodetic data, proximity to the hypocenter location and Coulomb stress changes at the aftershock locations, we conclude that the 2017 earthquake ruptured a north-dipping fault. We find that the earthquake occurred on a 20–25 km long, ∼E–W striking, 40° north-dipping, pure normal fault with slip primarily confined between 3 and 15 km depth, and the largest slip exceeding 2 m between depths of 4 and 10 km. The coseismic fault, not mapped previously, projects to the surface within the western Gulf, and partly serves both to widen the Gulf and separate Kos Island from the Bodrum Peninsula of SW Anatolia. The coseismic fault may be an extension of a mapped, north-dipping normal fault along the south side of the Gulf of Gökova. While all of the larger aftershocks are consistent with N–S extension, their spatially dispersed pattern attests to the high degree of crustal fracturing within the basin, due to rapid trenchward extension and anticlockwise rotation within the southeastern Aegean.
Updated attenuation tomography of Japan subduction zone
Authors: Wang Zewei , Zhao Dapeng 
Published: July 2019

SUMMARYWe determine an updated model of P- and S-wave attenuation (Qp, Qs) tomography of the Japan subduction zone using an improved inversion scheme, and derive the first Qp/Qs model of the study region. We establish a system of observation t* equations by taking 1/Q values at 3-D grid nodes arranged in the study volume as unknown parameters. This scheme can eliminate model errors caused by ignoring high-order terms of the Taylor expansion in the Q-format scheme adopted by previous studies. The inversion problem is considered as a quadratic programming problem with bound constraints for best fitting the observed t* data in a least-squares sense. The 3-D attenuation model is obtained by using a limited-memory Broyden–Fletcher–Goldfarb–Shanno algorithm for bound constrained optimization. Because this inversion scheme uses bound constraints to avoid negative Q values, damping regularization is not needed, hence the ranges of Qp and Qs values obtained are less affected by human subjectivity. The subducting Pacific and Philippine Sea slabs exhibit high-Q and high Qp/Qs, whereas the mantle wedge beneath the volcanic front and back-arc area shows low-Q and low Qp/Qs. Both Qp and Qs vary in a range of 10–2000, and the Qp/Qs ratio changes from 0.4 to 1.4. Our results reveal a narrow high-Qp/Qs belt that is coincident with the distribution of volcanic and non-volcanic low-frequency micro-earthquakes (M 0.0–2.5), which may reflect high water-saturation anomalies that are probably associated with slab-derived fluids and responsible for the generation of low-frequency micro-earthquakes.
Patient-experience during delivery in public health facilities in Uttar Pradesh, India
Authors: Montagu Dominic , Landrian Amanda , Kumar Vishwajeet , Phillips Beth S , Singhal Shreya , Mishra Shambhavi , Singh Shambhavi , Cotter Sun Yu , Singh Vinay Pratap , Kajal Fnu , Sudhinaraset May 
Published: July 2019

Abstract
In India, most women now delivery in hospitals or other facilities, however, maternal and neonatal mortality remains stubbornly high. Studies have shown that mistreatment causes delays in care-seeking, early discharge and poor adherence to post-delivery guidance. This study seeks to understand the variation of women’s experiences in different levels of government facilities. This information can help to guide improvement planning. We surveyed 2018 women who gave birth in a representative set of 40 government facilities from across Uttar Pradesh (UP) state in northern India. Women were asked about their experiences of care, using an established scale for person-centred care. We asked questions specific to treatment and clinical care, including whether tests such as blood pressure, contraction timing, newborn heartbeat or vaginal exams were conducted, and whether medical assessments for mothers or newborns were done prior to discharge. Women delivering in hospitals reported less attentive care than women in lower-level facilities, and were less trusting of their providers. After controlling for a range of demographic attributes, we found that better access, higher clinical quality, and lower facility-level, were all significantly predictive of patient-centred care. In UP, lower-level facilities are more accessible, women have greater trust for the providers and women report being better treated than in hospitals. For the vast majority of women who will have a safe and uncomplicated delivery, our findings suggest that the best option would be to invest in improvements mid-level facilities, with access to effective and efficient emergency referral and transportation systems should they be needed.
Attitudes, knowledge and sexual behavior among Finnish adolescents before and after an intervention
Authors: Pakarinen Marja , Kylmä Jari , Helminen Mika , Suominen Tarja 
Published: July 2019

Abstract
Adolescents are an important target group for sexual health promotion, and there are numerous programs and interventions carried out in this field. The aim of this study is to describe adolescents’ attitudes, knowledge and sexual behavior before and after a sexual health promotion intervention. The intervention was developed in the study and consisted of three elements: (i) class-room session, (ii) information materials and (iii) free condom distribution. The study was carried out in eight randomly selected vocational schools in Finland. The participants were first year students aged 15–19 years. The data were collected using an electronic questionnaire before intervention (intervention baseline n = 500, control baseline n = 183) and two times after the intervention (intervention first follow-up n = 173/second follow-up n = 202, control first follow-up n = 115/second follow-up n = 46). There were significant differences before and after the intervention concerning better knowledge and more frequent testing for sexually transmitted infections (STIs). Schools are an important environment to reach adolescents during the phase where their sexual health is developing and there is an increased risk of STI transmission. More school-based interventions are therefore needed, and the results of this study can be utilized when developing sexual health promotion interventions among adolescents.
Applying intersectionality theory in health promotion research and practice
Authors: Heard Emma , Fitzgerald Lisa , Wigginton Britta , Mutch Allyson 
Published: July 2019

Abstract
Health promotion researchers and practitioners are grappling with how to address growing health inequalities for population groups. In particular, critiques of dominant behaviour change approaches draw attention to the need to engage with social theories to better understand the social and relational drivers of health. Public health researchers are increasingly acknowledging intersectionality as an important theoretical approach, providing a framework for investigating health inequalities by highlighting intersections of individuals’ multiple identities within social systems of power that compound and exacerbate experiences of ill health. This article provides an overview of the diverse ways public health researchers and practitioners have applied intersectionality theory to better understand and address health inequalities. We map three key applications of intersectionality theory in public health: as an epistemological approach, as a methodological approach, and as a tool for action and intervention. Drawing on this work, we argue that health promotion researchers and practitioners can enhance engagement with intersectionality theory to address important challenges within the field. Through this article, we aim to inspire the continued exploration of intersectionality and offer some insights into opportunities and challenges for doing so in health promotion.
The repair of endo/exogenous DNA double-strand breaks and its effects on meiotic chromosome segregation in oocytes
Authors: Ma Jun-Yu , Feng Xie , Tian Xin-Yi , Chen Lei-Ning , Fan Xiao-Yan , Guo Lei , Li Sen , Yin Shen , Luo Shi-Ming , Ou Xiang-Hong 
Published: July 2019

Abstract
Germ cell-derived genomic structure variants not only drive the evolution of species but also induce developmental defects in offspring. The genomic structure variants have different types, but most of them are originated from DNA double-strand breaks (DSBs). It is still not well known whether DNA DSBs exist in adult mammalian oocytes and how the growing and fully grown oocytes repair their DNA DSBs induced by endogenous or exogenous factors. In this study, we detected the endogenous DNA DSBs in the growing and fully grown mouse oocytes and found that the DNA DSBs mainly localized at the centromere-adjacent regions, which are also copy number variation hotspots. When the exogenous DNA DSBs were introduced by Etoposide, we found that Rad51-mediated homologous recombination (HR) was used to repair the broken DNA. However, the HR repair caused the chromatin intertwined and impaired the homologous chromosome segregation in oocytes. Although we had not detected the indication about HR repair of endogenous centromere-adjacent DNA DSBs, we found that Rad52 and RNA:DNA hybrids colocalized with these DNA DSBs, indicating that a Rad52-dependent DNA repair might exist in oocytes. In summary, our results not only demonstrated an association between endogenous DNA DSBs with genomic structure variants but also revealed one specific DNA DSB repair manner in oocytes.
Tbx5 inhibits hedgehog signaling in determination of digit identity
Authors: Xu Huiting , Xiang Menglan , Qin Yushu , Cheng Henghui , Chen Duohua , Fu Qiang , Zhang Ke K , Xie Linglin 
Published: July 2019

AbstractDominant TBX5 mutation causes Holt-Oram syndrome (HOS), which is characterized by limb defects in humans, but the underlying mechanistic basis is unclear. We used a mouse model with Tbx5 conditional knockdown in Hh-receiving cells (marked by Gli1+) during E8 to E10.5, a previously established model to study atrial septum defects, which displayed polydactyly or hypodactyly. The results suggested that Tbx5 is required for digit identity in a subset of limb mesenchymal cells. Specifically, Tbx5 deletion in this cell population decreased cell apoptosis and increased the proliferation of handplate mesenchymal cells. Furthermore, Tbx5 was found to negatively regulate the Hh-signaling activity through transcriptional regulation of Ptch1, a known Hh-signaling repressor. Repression of Hh-signaling through Smo co-mutation in Tbx5 heterozygotes rescued the limb defects, thus placing Tbx5 upstream of Hh-signaling in limb defects. This work reveals an important missing component necessary for understanding not only limb development but also the molecular and genetic mechanisms underlying HOS.
Adaptation and Evolution of Biological Materials
Authors: Campbell Robert A , Dean Mason N 
Published: July 2019

Abstract
Research into biological materials often centers on the impressive material properties produced in Nature. In the process, however, this research often neglects the ecologies of the materials, the organismal contexts relating to how a biological material is actually used. In biology, materials are vital to organismal interactions with their environment and their physiology, and also provide records of their phylogenetic relationships and the selective pressures that drive biological novelties. With the papers in this symposium, we provide a view on cutting-edge work in biological materials science. The collected research delivers new perspectives on fundamental materials concepts, offering surprising insights into biological innovations and challenging the boundaries of materials’ characterization techniques. The topics, systems, and disciplines covered offer a glimpse into the wide range of contemporary biological materials work. They also demonstrate the need for progressive “whole organism thinking” when characterizing biological materials, and the importance of framing biological materials research in relevant, biological contexts.
Clinical usefulness of prethymectomy plasmapheresis in patients with myasthenia gravis: a systematic review and meta-analysis
Authors: Reis Tarcisio A , Cataneo Daniele C , Cataneo Antônio Jose Maria 
Published: July 2019

AbstractOBJECTIVESOur goal was to evaluate, through a systematic review, the efficacy of plasmapheresis in the preoperative preparation of the patient for a thymectomy for the treatment of myasthenia gravis.METHODSMEDLINE, Embase, LILACS, Scopus and CENTRAL databases were searched. The following outcomes were evaluated: myasthenic crisis, mortality, pneumonia, bleeding, use of mechanical ventilation, length of hospital stay and intensive care unit (ICU) stay. RevMan 5.3 software provided by the Cochrane Collaboration was used for the meta-analysis.RESULTSThe total number of patients evaluated in the 7 included studies was 360. Plasmapheresis during the preoperative period did not decrease the myasthenic crisis [risk ratio (RR) 0.36, 95% confidence interval (CI) 0.08–1.66; I2 = 44%; 5 studies, 243 patients]. There was also no change in the mortality rate (RR 0.7, 95% CI 0.11–4.62; I2 = 0%; 3 studies, 172 patients) or pneumonia cases (RR 0.28, 95% CI 0.07–1.09; I2 = 27%; 5 studies, 272 patients). Bleeding was greater in patients who underwent plasmapheresis (mean difference 34.34 ml; 95% CI 24.93–43.75; I2 = 0%). We evaluated the following outcomes: need for mechanical ventilation, hospital stay, ICU stay and mechanical ventilation, but these outcomes were not adequate to perform the meta-analysis due to the high heterogeneity among the studies. Subgroup analysis showed that plasmapheresis performed during the preoperative period in patients with severe disease (Osserman III and IV) decreased the myasthenic crisis postoperatively (RR 0.12, 95% CI 0.02–0.65; I2 = 63%).CONCLUSIONSPlasmapheresis may reduce the myasthenic crisis during the postoperative period in patients with severe disease but may produce little or no difference in patients with mild clinical expression of the disease.
Somatic and cerebral near infrared spectroscopy for the monitoring of perfusion during neonatal cardiopulmonary bypass
Authors: Bojan Mirela , Bonaveglio Enrico , Dolcino Andrea , Mirabile Cristian 
Published: July 2019

AbstractOBJECTIVESThe somatic-cerebral regional oxygen saturation (rSO2) gradient has the potential to reveal a low cardiac output state at an early stage, when systemic vascular resistance increases in order to maintain cerebral perfusion, and results in a drop in somatic rSO2. We hypothesized that during neonatal cardiopulmonary bypass (CPB), the somatic-cerebral rSO2 gradient can also signal poor perfusion, as assessed by an increase in lactate concentration.METHODSIn a retrospective review of neonatal bypass records, we investigated the association between the somatic-cerebral rSO2 gradient and serial lactate measurements. The somatic-cerebral rSO2 gradient, i.e. the area between the somatic and cerebral rSO2, was calculated for each CPB time interval between 2 lactate measurements, using the trapezoidal method. The association between the somatic-cerebral rSO2 gradient and lactate variation was explored using a mixed model for repeated measurements adjusted for the CPB temperature across intervals.RESULTSA total of 94 CPB intervals were analysed in 24 neonates, median age 6 days, median weight 3.1 kg. The median lactate variation per interval was +0.2 mmol l−1 (range −1.5 to +2.7), the median somatic-cerebral gradient was 0 (range −1229% min to +2049% min) and the median CPB temperature was 29.5°C (IQR 28.1–33.4). There was an independent association between the lactate increase and the somatic-cerebral rSO2 gradient (regression coefficient = −0.0006 ± 0.0002, P = 0.009).CONCLUSIONSA decrease in the somatic-cerebral rSO2 gradient was associated with an increase in lactate concentration, suggesting that the somatic-cerebral rSO2 gradient is a useful monitoring tool for the adequacy of perfusion during neonatal CPB.
Long-term quality of life in adults following truncus arteriosus repair
Authors: Tay Hilson , Naimo Phillip S , Huang Li , Fricke Tyson A , Brink Johann , d’Udekem Yves , Brizard Christian P , Konstantinov Igor E 
Published: July 2019

OBJECTIVES

To date, few studies have assessed the quality of life following congenital cardiac surgery. In this study, we aimed at determining the quality of life after truncus arteriosus (TA) repair using the Short Form 36 questionnaire in adult survivors.

METHODS
Seventy-three patients (age >18 years) who underwent TA repair at the Royal Children’s Hospital, Australia were identified for the study. Of these, 42 patients (58%, 42/73) participated in the study and completed the Short Form 36 questionnaire. The results of the 8 domains and the derived health state summary score (Short Form Six Dimension, SF-6D) were compared with age-matched Australian population controls, and with patients who underwent the arterial switch operation (ASO).

RESULTS
Compared with the age-matched Australian population, 18- to 24-year-old TA patients (31%, 13/42) had lower scores in 6 of 8 domains; 25- to 34-year-old TA patients (36%, 15/42) scored lower in 5 of 8 domains; and 35- to 44-year-old TA patients (33%, 14/42) scored lower in 4 of 8 domains. SF-6D scores were not significantly different between TA patients and the age-matched Australian population. Compared with patients who underwent ASO, 18-to 24-year-old TA patients scored lower in 3 of 8 domains; and 25- to 34-year-old TA patients scored lower in 2 of 8 domains. There was no significant difference in SF-6D scores between TA and patients who underwent the ASO.

CONCLUSIONS
Adult survivors of TA have similar quality of life compared with age-matched Australian controls measured by SF-6D. Despite a higher reoperation rate in TA patients, they have similar quality of life compared with ASO patients.
Ischaemic papillary muscle rupture without significant coronary artery lesion
Authors: Kitada Yuichiro , Arakawa Mamoru , Miyagawa Atsushi , Okamura Homare 
Published: July 2019

Abstract
Papillary muscle rupture is a rare but life-threatening complication of myocardial infarction (MI). Here, we describe a case of papillary muscle rupture caused by a microscopic MI. A 76-year-old woman was referred to our institution, where she developed cardiac arrest upon admission. Severe mitral regurgitation was noted without significant coronary artery lesions. Emergency surgery was performed, and posteromedial papillary muscle rupture was observed. Postoperatively, cardiac magnetic resonance imaging revealed a microscopic MI of the posteromedial papillary muscle.
Character Ratios for Exceptional Groups of Lie Type
Authors: Liebeck Martin W , Tiep Pham Huu 
Published: July 2019

AbstractWe prove character ratio bounds for finite exceptional groups $G(q)$ of Lie type. These take the form $\dfrac{|\chi (g)|}{\chi (1)} \le \dfrac{c}{q^k}$ for all nontrivial irreducible characters $\chi$ and nonidentity elements $g$, where $c$ is an absolute constant, and $k$ is a positive integer. Applications are given to bounding mixing times for random walks on these groups and also diameters of their McKay graphs.
Transient Immune Activation in BCG-Vaccinated Infant Rhesus Macaques Is Not Sufficient to Influence Oral Simian Immunodeficiency Virus Infection
Authors: Wood Matthew P , Wood Lianna F , Templeton Megan , Fisher Bridget , Lippy Adriana , Jones Chloe I , Lindestam Arlehamn Cecilia S , Sette Alessandro , Fuller James T , Murapa Patience , Jaspan Heather B , Fuller Deborah H , Sodora Donald L 
Published: July 2019

AbstractBCG vaccination has been demonstrated to increase levels of activated CD4+ T cells, thus potentially influencing mother-to-child transmission of human immunodeficiency virus (HIV). To assess the risk of BCG vaccination in HIV infection, we randomly assigned newborn rhesus macaques to receive BCG vaccine or remain unvaccinated and then undergo oral simian immunodeficiency virus (SIV) challenges 3 weeks later. We observed elevated levels of activated peripheral CD4+ T cells (ie, HLA-DR+CD38+CCR5+ CD4+ T cells) by week 3 after vaccination. BCG was also associated with an altered immune gene expression profile, as well as with monocyte activation in both peripheral blood and the draining axillary lymph node, indicating significant BCG vaccine–induced immune activation. Despite these effects, BCG vaccination did not increase the rate of SIV oral transmission or disease progression. Our findings therefore identify patterns of T-cell and monocyte activation that occur after BCG vaccination but do not support the hypothesis that BCG vaccination is a risk factor for postnatal HIV transmission or increased pathogenesis in infants.
Efficacy of Oral Tenofovir Alafenamide/Emtricitabine Combination or Single-Agent Tenofovir Alafenamide Against Vaginal Simian Human Immunodeficiency Virus Infection in Macaques
Authors: Massud Ivana , Cong Mian-Er , Ruone Susan , Holder Angela , Dinh Chuong , Nishiura Kenji , Khalil George , Pan Yi , Lipscomb Jonathan , Johnson Ryan , Deyounks Frank , Rooney James F , Babusis Darius , Park Yeojin , McCallister Scott , Callebaut Christian , Heneine Walid , García-Lerma J Gerardo 
Published: July 2019

AbstractBackgroundTenofovir alafenamide (TAF)-based regimens are being evaluated for pre-exposure prophylaxis (PrEP). We used a macaque model of repeated exposures to simian human immunodeficiency virus (SHIV) to investigate whether TAF alone or the combination of TAF and emtricitabine (FTC) can prevent vaginal infection.MethodsPigtail macaques were exposed vaginally to SHIV162p3 once a week for up to 15 weeks. Animals received clinical doses of FTC/TAF (n = 6) or TAF (n = 9) orally 24 hours before and 2 hours after each weekly virus exposure. Infection was compared with 21 untreated controls.ResultsFive of the 6 animals in the FTC/TAF and 4 of the 9 animals in the TAF alone group were protected against infection (P = .001 and P = .049, respectively). The calculated efficacy of FTC/TAF and TAF was 91% (95% confidence interval [CI], 34.9%–98.8%) and 57.8% (95% CI, −8.7% to 83.6%), respectively. Infection in FTC/TAF but not TAF-treated macaques was delayed relative to controls (P = .005 and P = .114). Median tenofovir diphosphate (TFV-DP) levels in peripheral blood mononuclear cells (PBMCs) were similar among infected and uninfected macaques receiving TAF PrEP (351 and 143 fmols/106 cells, respectively; P = .921).ConclusionsEmtricitabine/TAF provided a level of protection against vaginal challenge similar to FTC/TFV disoproxil fumarate combination in the macaque model. Our results support the clinical evaluation of FTC/TAF for PrEP in women.