bluuebunny/crossref_metadata_2025_split huggingface dataset:
New doctors ranking system based on VIKOR method
Authors: Hu Junhua , Zhang Xiaohong , Yang Yan , Liu Yongmei , Chen Xiaohong 
Published: June 2018

AbstractNowadays, we can use different websites that help us make decisions about various aspects of our lives. However, privacy protection prevents websites from providing personalised guidelines to users. We propose a novel doctor‐ranking system (DRS) based on multi‐criteria group decision‐making (MCGDM) method to address the problems of privacy protection. The following aspects differentiate our proposed DRS model from previous works: (a) textual information reviews are used to identify user preferences and complementary criteria, (b) criteria weights are determined by term frequency inverse document frequency (TF‐IDF) instead of Delphi method or expert opinion, (c) intuitionistic fuzzy sets (IFSs) are used to replace sentiment analysis to express subjective user criteria, and (d) VIsekriterijumsko KOmpromisno Rangiranjie (VIKOR) method for MCGDM with IFSs is used to solve the doctor‐ranking problem. We apply our proposed model to datasets from Haodf.com to compare the performance of our method with that of sentiment analysis and technique for order performance by similarity to ideal solution (TOPSIS) methods. The experimental results show that our method provides accurate ranking and increases the reliability of DRS.
A nonlinear optimization model for the balanced vehicle routing problem with loading constraints
Authors: Vega‐Mejía Carlos A. , Montoya‐Torres Jairo R. , Islam Sardar M. N. 
Published: June 2018

AbstractThe vehicle routing problem with loading constraints (VRPLC) is related to real‐life transportation problems and integrates two of the most important activities in distribution logistics: packing of items inside vehicles and planning of delivery routes. In spite of its relevance, literature on VRPLCs is still limited. The majority of the solution approaches have concentrated on heuristic solution methods, and few have presented mathematical optimization models to help characterize the problem. Furthermore, few studies have considered several practical loading and routing constraints that could be used to approximate the problem toward more realistic situations. To help fill this gap in the literature, this article extends an existing VRPLC optimization model to a nonlinear optimization model that considers weight‐bearing strength of three‐dimensional items, vehicle weight capacity, weight distribution inside vehicles, delivery time windows, and a balanced fleet of vehicles. The model is solved by applying a simple procedure that isolates the nonlinearity of the model. Computational experiments show that the new proposed model gives a more streamlined formulation than the model it extended on, and that the addition of practical loading constraints can improve the solutions of the original model by reducing the measure of tardiness due to late deliveries and by producing cargo patterns with better weight distribution.
Phenotypic features of central sensitization
Authors: Williams David A. 
Published: June 2018

AbstractThe current manuscript reviews approaches for phenotyping central sensitization (CS).The manuscript covers the concept of diagnostic phenotyping, use of endophenotypes, biomarkers, and symptom clusters. Specifically, the components of CS that include general sensory sensitivity (assessed by quantitative sensory testing) and a symptom cluster denoting sleep difficulties, pain, affect, cognitive difficulties, and low energy (S.P.A.C.E.).Each of the assessment domains are described with reference to CS and their presence in chronic overlapping pain conditions (COPCs)—conditions likely influenced by CS.Chronic overlapping pain conditions likely represent clinical diagnostic phenotypes of CS. Components of CS can also be assessed using QST or self‐report instruments designed to assess single elements of CS or more general composite indices.
The neurobiology of central sensitization
Authors: Harte Steven E. , Harris Richard E. , Clauw Daniel J. 
Published: June 2018

AbstractCentral sensitization refers to the amplification of pain by central nervous system mechanisms. Classically described as a consequence of ongoing nociceptive input, it is increasingly recognized that central sensitization also occurs independent of peripheral injury or inflammation. Features of central sensitization have been identified in nearly all chronic pain conditions, and it is considered the primary underlying cause of pain in conditions such as fibromyalgia. Central sensitization is characterized in these conditions by widespread pain and multisite hyperalgesia/allodynia. Co‐occurring symptoms include fatigue, mood and cognitive problems, sleep disturbances, and multisensory hypersensitivity. Individuals with central sensitization often report previous exposure to psychosocial or physical stressors, and a higher personal lifetime and family history of pain, with the latter findings supported by genetic studies. Neuroimaging studies of central sensitization show evidence of: changes in brain gray matter in pain processing regions; neurochemical imbalances; and altered resting brain‐network connectivity between pronociceptive and antinociceptive brain areas. Immune system abnormalities have also been demonstrated in individuals with central sensitization. The recognition of central sensitization, and whether it is being driven by ongoing nociceptive input or it is occurring in the absence of a peripheral driver, is critical for effective pain management.
Effects of CuO on constrained sintering of a polycrystalline TiO2 ceramics
Authors: Lee Cheng‐Fan , Wu Cheng‐Feng , Jean Jau‐Ho 
Published: June 2018

AbstractEffects of CuO on constrained sintering of a polycrystalline TiO2 ceramics have been investigated. The densification temperature of TiO2 is reduced from 1100‐1200°C for pure TiO2 to 900°C with the presence of 0.5‐3 mol% CuO under free sintering. For the samples with 1 mol% CuO, the constrained densification is slowed down, but a high sintered density of >95% at 950°C, which is close to that sintered freely, is still obtained. The above results are caused by the formation of CuO‐rich film at the grain boundaries, which reduces grain‐boundary energy and enhances grain‐boundary migration kinetics of TiO2. To confirm the above findings, molecular dynamics simulation, at which the ratio of grain boundary energy of TiO2 between with and without CuO agrees well with that obtained experimentally, is conducted.
Job satisfaction among disabled people in the sheltered workshop: Differential analysis
Authors: Lukas Jose Francisco , Lizasoain Luis , Galarreta Javier , Etxeberria Juan 
Published: June 2018

AbstractThis paper analyses job satisfaction and differences in factors affecting it among workers with an intellectual disability and mental illness (MI) depending on their work regime [special employment regime (SER) or occupational service (OS)]. To do so, answers were analysed from 874 participants on a Job Satisfaction Scale used in sheltered workshops in Spain. The results indicate that job satisfaction among workers with intellectual disability and MI in both the SER and the OS regimes is high, with the highest job satisfaction deriving from the Items of communicating problems to resolve them. The lowest levels of job satisfaction are related to the opportunity to take decisions and participate at work. In the majority of the Items analysed, no differences were found on the basis of the age groups considered nor the gender of the participants.
Health indicators in intellectual developmental disorders: The key findings of the POMONA‐ESP project
Authors: Folch Annabel , Salvador‐Carulla Luis , Vicens Paloma , Cortés Maria José , Irazábal Marcia , Muñoz Silvia , Rovira Lluís , Orejuela Carmen , González Juan A. , Martínez‐Leal Rafael 
Published: June 2018

AbstractBackgroundThe aim of this paper was to summarize the main results of the POMONA‐ESP project, the first study to explore health status in a large representative, randomized and stratified sample of people with intellectual developmental disorders in Spain.MethodsThe POMONA‐ESP project collected information about the health of 953 individuals with intellectual developmental disorders.ResultsDiseases such as urinary incontinence, oral problems, epilepsy, constipation or obesity were highly prevalent among the participants; with gender‐differentiated prevalences for certain conditions, and age and intellectual disability level as risk factors for disease. Overmedication was common in the sample, and drugs were often prescribed without any clinical indication or follow‐up. The present authors also found a lack of important relevant information about the participant's health and a lack of adequate genetic counselling.ConclusionsOur findings may contribute to a better understanding of health status and needs of people with intellectual developmental disorders and suggest several courses of action to improve their health care.
Efficacy and safety of insulin glargine 300 U/mL vs insulin degludec in patients with type 2 diabetes: A randomized, open‐label, cross‐over study using continuous glucose monitoring profiles
Authors: Kawaguchi Yuji , Sawa Jun , Sakuma Noriko , Kumeda Yasuro 
Published: June 2018

AbstractAims/IntroductionCompared with glargine 100 U/mL (Gla100), glargine 300 U/mL (Gla300) and degludec (Deg) – the ultralong‐acting insulins – reportedly have more stable effects and reduce the risk of hypoglycemia. Currently, they are considered to be the most useful basal insulins. The present study aimed to compare the efficacy and safety of Gla300 and Deg on glycemic control using continuous glucose monitoring.Materials and MethodsIn this single‐center, open‐label, parallel‐group, two‐period, cross‐over study, 30 patients with type 2 diabetes were randomized to once‐daily Gla300 followed by Deg with the same units (n = 15) or vice versa (n = 15). The primary end‐points of this study were the mean percentage of time within the target glucose range of 70–180 mg/dL as efficacy and hypoglycemia of <70 mg/dL as safety indicators, as measured using continuous glucose monitoring during each treatment period.ResultsThe mean percentage of time within the target glucose range was not different between Gla300 and Deg (77.8 ± 19.2 vs 76.9 ± 18.3%, P = 0.848). However, the mean percentage of time of hypoglycemia with Gla300 was significantly lower than that of Deg (1.3 ± 2.7 vs 5.5 ± 6.4%, P = 0.002). In the secondary safety end‐points, the mean percentage of time of severe hypoglycemia (<54 mg/dL) or nocturnal hypoglycemia with Gla300 was also significantly lower than that of Deg.ConclusionsThe present study showed the comparable efficacy of Gla300 and Deg on glycemic control; however, the risk of hypoglycemia was markedly lower for Gla300 than for Deg.
Nursing students' experiences of using a smart phone application for a physical assessment course: A qualitative study
Authors: Hsu Li‐Ling , Hsiang Hsiu‐Chuan , Tseng Yi‐Hua , Huang Siang‐Yun , Hsieh Suh‐Ing 
Published: June 2018

AimIt is important that nurses possess adequate clinical skills so that the patient receives safe and competent care. Smart phone applications (apps) can promote active learning and the long‐term retention of knowledge of undergraduate students. Therefore, the aim of this study was to explore the thoughts and experiences of nursing students who received a smart phone, app‐based physical assessment educational intervention.MethodsA qualitative descriptive approach with in‐depth interviews was considered as suitable to obtain a comprehensive understanding of students' experiences of a smart phone‐enabled physical assessment course.ResultsBased on interviews with 16 nursing students following the intervention, five themes were derived from the analysis of the interview transcripts: “the APP's physical assessment scenarios are very close to real‐life clinical situations,” “watching physical assessment videos over the APP is a quick way to learn what to do,” “the APP is a new way of learning that enhances thinking and reflection,” “some nursing students felt that it was out of their depth to analyze the scenarios in the APP,” and “the APP needs enhancements in stability and interactivity.”ConclusionThe findings of this study showed the mobile app as an effective learning aid that promoted transferability of the nursing students' knowledge and past experience. With the help of the APP, the teachers could offer timely guidance to the students.
Consanguinity increases the risk for aggressive periodontitis
Authors: Çalışır M. 
Published: June 2018

Background and ObjectiveGenetic predisposition is an important factor for developing aggressive periodontitis (AgP); however, previous studies only focused on individual families where consanguineous marriages have not been considered. Thus, there is a debate in the understanding of the genetic features of this disease. The present study aims to compare the genetic features of AgP in individuals with and without history of consanguineous marriages.Material and MethodsThirty‐three probands from 16 pedigrees with history of consanguineous marriage and 17 pedigrees without history of consanguineous marriage were analyzed in terms of heritability of AgP. Detailed clinical evaluations of the probands showing their periodontal health and their family medical histories were obtained. The gingival index, plaque index, bleeding on probing, suppuration, probing pocket depth and clinical attachment level data were analyzed and compared between groups. The gender differences were also taken into account to determine the mode of inheritance of AgP.ResultsThe gingival index, bleeding on probing, suppuration, probing pocket depth and clinical attachment level scores were significantly different between the affected and unaffected groups for both genders, which were consistent with the diagnosis of AgP. Strikingly, when the consanguineous group and the non‐consanguineous group were compared, the siblings of the consanguineous group displayed approximately 8 times more prevalence of AgP (15.15%) compared to the siblings of the probands in the non‐consanguineous group (1.89%) (P = .022). In addition, the mode of transmission of the disease was found to fit better to the autosomal recessive inheritance pattern.ConclusionCurrent findings indicate that AgP is segregated on autosomal chromosomes and consanguineous marriage increases the likelihood of developing this disease.
The Xanthomonas effector XopK harbours E3 ubiquitin‐ligase activity that is required for virulence
Authors: Qin Jun , Zhou Xiaogang , Sun Lifan , Wang Kailun , Yang Fan , Liao Haicheng , Rong Wei , Yin Junjie , Chen Huamin , Chen Xuewei , Zhang Jie 
Published: June 2018

Summary

Xanthomonas oryzae pv. oryzae is the causative agent of rice bacterial leaf blight. While the type III secretion system of X. oryzae pv. oryzae is essential for virulence, the biochemical activities and virulence mechanisms of non‐transcription activator‐like (non‐TAL) effectors delivered by this system are largely unknown.

Here, by screening for non‐TAL effectors that contribute to X. oryzae pv. oryzae virulence, we revealed that Xanthomonas outer protein K (XopK) inhibits pathogen‐associated molecular pattern‐triggered immunity upstream of mitogen‐activated protein kinase cascades.

Specifically, XopK interacted with and directly ubiquitinated rice somatic embryogenic receptor kinase 2 (OsSERK2), resulting in its degradation. Accordingly, mutation of a putative ubiquitin‐conjugation enzyme (E2) binding site abolished XopK‐induced degradation of OsSERK2 and compromised XopK‐dependent virulence.

As crucial immune regulators associated with a multitude of immune receptors, SERKs have been shown to be perturbed by Pseudomonas effectors via different mechanisms. Our study revealed a distinct perturbation mechanism of SERK activity via ubiquitination achieved by Xanthomonas non‐TAL effector.
ORESARA15, a PLATZ transcription factor, mediates leaf growth and senescence in Arabidopsis
Authors: Kim Jin Hee , Kim Jeongsik , Jun Sang Eun , Park Sanghoon , Timilsina Rupak , Kwon Da Som , Kim Yongmin , Park Sung‐Jin , Hwang Ji Young , Nam Hong Gil , Kim Gyung‐Tae , Woo Hye Ryun 
Published: June 2018

Summary

Plant leaves undergo a series of developmental changes from leaf primordium initiation through growth and maturation to senescence throughout their life span. Although the mechanisms underlying leaf senescence have been intensively elucidated, our knowledge of the interrelationship between early leaf development and senescence is still fragmentary.

We isolated the oresara15‐1Dominant (ore15‐1D) mutant, which had an extended leaf longevity and an enlarged leaf size, from activation‐tagged lines of Arabidopsis. Plasmid rescue identified that ORE15 encodes a PLANT A/T‐RICH SEQUENCE‐ AND ZINC‐BINDING PROTEIN family transcription factor. Phenotypes of ore15‐1D and ore15‐2, a loss‐of‐function mutant, were evaluated through physiological and anatomical analyses. Microarray, quantitative reverse transcription polymerase chain reaction, and chromatin immunoprecipitation as well as genetic analysis were employed to reveal the molecular mechanism of ORE15 in the regulation of leaf growth and senescence.

ORE15 enhanced leaf growth by promoting the rate and duration of cell proliferation in the earlier stage and suppressed leaf senescence in the later stage by modulating the GROWTH‐REGULATING FACTOR (GRF)/GRF‐INTERACTING FACTOR regulatory pathway.

Our study highlighted a molecular conjunction through ORE15 between growth and senescence, which are two temporally separate developmental processes during leaf life span.
Broad spectrum developmental role of Brachypodium AUX1
Authors: van der Schuren Alja , Voiniciuc Catalin , Bragg Jennifer , Ljung Karin , Vogel John , Pauly Markus , Hardtke Christian S. 
Published: June 2018

Summary

Targeted cellular auxin distribution is required for morphogenesis and adaptive responses of plant organs. In Arabidopsis thaliana (Arabidopsis), this involves the prototypical auxin influx facilitator AUX1 and its LIKE‐AUX1 (LAX) homologs, which act partially redundantly in various developmental processes. Interestingly, AUX1 and its homologs are not strictly essential for the Arabidopsis life cycle. Indeed, aux1 lax1 lax2 lax3 quadruple knock‐outs are mostly viable and fertile, and strong phenotypes are only observed at low penetrance.

Here we investigated the Brachypodium distachyon (Brachypodium) AUX1 homolog BdAUX1 by genetic, cell biological and physiological analyses.

We report that BdAUX1 is essential for Brachypodium development. Bdaux1 loss‐of‐function mutants are dwarfs with aberrant flower development, and consequently infertile. Moreover, they display a counter‐intuitive root phenotype. Although Bdaux1 roots are agravitropic as expected, in contrast to Arabidopsis aux1 mutants they are dramatically longer than wild type roots because of exaggerated cell elongation. Interestingly, this correlates with higher free auxin content in Bdaux1 roots. Consistently, their cell wall characteristics and transcriptome signature largely phenocopy other Brachypodium mutants with increased root auxin content.

Our results imply fundamentally different wiring of auxin transport in Brachypodium roots and reveal an essential role of BdAUX1 in a broad spectrum of developmental processes, suggesting a central role for AUX1 in pooideae.
A multicentre study of oral paracoccidioidomycosis: Analysis of 320 cases and literature review
Authors: de Arruda José Alcides Almeida , Schuch Lauren Frenzel , Abreu Lucas Guimarães , Silva Leni Verônica de Oliveira , Mosconi Carla , Monteiro João Luiz Gomes Carneiro , Batista Aline Carvalho , Hildebrand Laura de Campos , Martins Manoela Domingues , Sobral Ana Paula Veras , Rivero Elena Riet Correa , Gomes Ana Paula Neutzling , Silva Tarcília Aparecida , Vasconcelos Ana Carolina Uchoa , Mesquita Ricardo Alves 
Published: June 2018

AbstractObjectivesTo investigate the frequency of oral paracoccidioidomycosis from representative geographical regions of Brazil and to compare the data with a literature review.Materials and methodsA retrospective study was conducted on 108,304 biopsies obtained from 1953 to 2016 at six Brazilian oral and maxillofacial pathology services. Demographic data and clinical and histopathological diagnosis of oral paracoccidioidomycosis were evaluated. A literature review of oral paracoccidioidomycosis studies published in three electronic databases was carried out. Data were analysed descriptively.ResultsA total of 320 cases of oral paracoccidioidomycosis were surveyed (0.3% of the oral lesions at the centres studied). The lesions were more frequent among male patients. The gingiva/alveolar ridge was the most affected site. Mean age of affected individuals was 51.3 years (±11.7). The literature review showed a higher incidence of oral paracoccidioidomycosis in the south‐east and south regions of Brazil. Male individuals and individuals between 50 and 59 years were most affected.ConclusionsOral paracoccidioidomycosis is an uncommon lesion observed in oral biopsy samples. The differences in the relative frequency of oral paracoccidioidomycosis are related to geographical variations. Men between 50 and 59 years are more affected. This study provides helpful information for clinicians in the diagnosis of oral paracoccidioidomycosis.
Virtual endocasts of fossil Sciuroidea: brain size reduction in the evolution of fossoriality
Authors: Bertrand Ornella C. , Amador‐Mughal Farrah , Lang Madlen M. , Silcox Mary T. 
Published: June 2018

AbstractAplodontia rufa (mountain beaver) is the only extant member of the Aplodontidae. The fossil record indicates that this family displayed greater taxonomic and ecological diversity in the past, and that the burrowing adaptations of Aplodontia might be derived. We describe the first virtual endocasts of A. rufa and of three fossil aplodontids: Prosciurus relictus and Pros. aff. saskatchewaensis (early Oligocene), and Mesogaulus paniensis (early Miocene). Our results show that the endocasts of early aplodontid rodents are more similar to those of early arboreal squirrels than to those of the later occurring aplodontids in terms of both relative size and morphology. The endocranial features observed in sciurids and early aplodontids, missing in later aplodontids, have been associated with better vision and the development of arboreality in squirrels. Basal Aplodontidae known from postcrania have been described as generalists with some features for arboreality, which may provide a basis for these similarities. In contrast, the relatively small endocasts of the later occurring aplodontids, which lack traits related to visual specialization, may reflect their burrowing adaptations, as they would be less reliant on visual cues. When integrated with data from the most primitive fossil rodents, the Ischyromyidae, these new data suggest that early squirrels and aplodontids diverged from more terrestrial ischyromyids to become more arboreal, with relatively larger brains showing traits for improved vision. Recent Aplodontidae with fossorial adaptations returned to a more ischyromyid‐like condition in their endocranial features. These results are consistent with previous observations that changes in locomotion are reflected in the endocranial anatomy of rodents.