bluuebunny/crossref_metadata_2025_split huggingface dataset:
A dual-wideband bandpass filter with closely spaced passbands using coupled lines and shunt transmission lines loaded with end-connected coupled lines
Authors: Alazemi Abdullah J. 
Published: November 2024

Abstract
A fourth-order bandpass filter with dual-wide passbands is proposed in this article. The novelty of the proposed work is the realization of a dual-band bandpass filter with closely spaced passbands, wide passband bandwidth, high rejection between the passbands, using a novel combination of open stub tapped series coupled lines (CLs) and shunt transmission line loaded with end connected CLs. The characteristics of the proposed dual-wideband bandpass filter are investigated by adopting even–odd mode analysis. The transmission zeros generated by the transmission line loaded with an end-connected CL and open stub are utilized to achieve a high skirt rate. A rejection better than 55 dB is achieved with a single transmission zero between the two passbands indicating high isolation and close passbands. The dual-wideband filter is designed and manufactured to operate at 1.33 and 2.32 GHz. The experimented 3-dB fractional bandwidths of the two pass frequency bands are 40.6% and 24.13%. The proposed filter’s tested frequency responses agree well with simulated results. The proposed device can be used in various applications such as telecommunications, satellite communications, radar systems, imaging, and spectroscopy.
Survey of Whistler‐Mode Wave Amplitudes and Frequency Spectra in Jupiter's Magnetosphere
Authors: Ma Q. , Li W. , Zhang X.‐J. , Kang N. , Bortnik J. , Qin M. , Shen X.‐C. , Meyer‐Reed C. J. , Artemyev A. V. , Kurth W. S. , Hospodarsky G. B. , Menietti J. D. , Bolton S. J. 
Published: November 2024

AbstractWe present statistical distributions of whistler‐mode chorus and hiss waves at frequencies ranging from the local proton gyrofrequency to the equatorial electron gyrofrequency (fce,eq) in Jupiter's magnetosphere based on Juno measurements. The chorus wave power spectral densities usually follow the fce,eq variation with major wave power concentrated in the 0.05fce,eq–fce,eq frequency range. The hiss wave frequencies are less dependent on fce,eq variation than chorus with major power concentrated below 0.05fce,eq, showing a separation from chorus at M < 10. Our survey indicates that chorus waves are mainly observed at 5.5 < M < 13 from the magnetic equator to 20° latitude, consistent with local wave generation near the equator and damping effects. The hiss wave powers extend to 50° latitude, suggesting longer wave propagation paths without attenuation. Our survey also includes the whistler‐mode waves at high latitudes which may originate from the Io footprint, auroral hiss, or propagating hiss waves reflected to high M shells.
Rapid Gas Bubble Growth in Basaltic Magma as a Source of Deep Long Period Volcanic Earthquakes
Authors: Melnik Oleg , Lyakhovsky Vladimir , Shapiro Nikolai M. 
Published: November 2024

AbstractIn this paper, we present numerical modeling aimed to explain Deep Long Period (DLP) events occurring in middle‐to‐lower crust beneath volcanoes and often observed in association with volcanic eruptions or their precursors. We consider a DLP generating mechanism caused by the rapid growth of gas bubbles in response to the slow decompression of H2O–CO2 over‐saturated basaltic magma. The nucleation and rapid growth of gas bubbles lead to rapid pressure change in the magma and elastic rebound of the host rocks, radiating seismic waves recorded as DLP events. The magma and host rocks are modeled as Maxwell bodies with different relaxation times and elastic moduli. Simulations of a single sill‐shaped intrusion with different parameters demonstrate that realistic amplitudes and frequencies of P and S seismic waves can be obtained when considering intrusions with linear sizes of the order of 100 m. We then consider a case of two closely located sills and model their interaction. We speculate on conditions that can result in consecutive triggering of the bubble growth in multiple closely located batches of magma, leading to the generation of earthquake swarms or seismic tremors.
Performance of the MOLES and TFSOM-DIM scores in classifying choroidal nevi and melanoma
Authors: Jahnke David , Grohmann Carsten , Fuisting Bettina , Skevas Christos , Spitzer Martin S. , Birtel Johannes 
Published: November 2024

AbstractChoroidal nevi are common benign melanocytic lesions often incidentally found during routine ophthalmic examinations. Patients with choroidal nevi are frequently referred to ocular oncology centers to differentiate these from choroidal melanoma and to exclude a malignant transformation which rarely occurs. However, this causes a high workload for referral centers and may delay diagnosis and treatment of patients with potentially severe conditions. To overcome this, the MOLES score was previously developed which may empower non-specialists to differentiate choroidal nevi from melanoma. In this retrospective study, the performance of the MOLES score was assessed in 695 patients with choroidal nevi and 53 with choroidal melanoma. With a specificity of 96% (choroidal nevi) and a sensitivity of 100% (melanoma) the MOLES score was highly successful in differentiating choroidal nevi from melanoma and may offer great potential to optimize monitoring and referral decisions, and for teleophthalmology applications. Furthermore, the TFSOM-DIM score using risk factors for determining tumor progression was applied and showed a good correlation with MOLES. A complementary use of MOLES and TFSOM-DIM may be beneficial for clinical routine: MOLES for screening by non-experts with limited diagnostic tools and TFSOM-DIM in a referral setting to counsel also regarding potential transformation.
Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells
Authors: Malla Sandhya , Martinez-Gamero Carlos , Kumari Kanchan , Achour Cyrinne , Mermelekas Georgios , Martinez-Delgado David , Coego Alba , Guallar Diana , Roman Angel-Carlos , Aguilo Francesca 
Published: November 2024

AbstractLysine-specific histone demethylase 1 (LSD1) is a histone demethylase that plays a critical role in epigenetic regulation by removing the methyl group from mono- and di-methylated lysine 4 on histone H3 (H3K4me1/2), acting as a repressor of gene expression. Recently, catalytically independent functions of LSD1, serving as a scaffold for assembling chromatin-regulator and transcription factor complexes, have been identified. Herein, we show for the first time that LSD1 interacts with chromodomain-helicase-DNA-binding protein 7 (CHD7) in mouse embryonic stem cells (ESCs). To further investigate the CHD7–LSD1 crosstalk, we engineered Chd7 and Chd7/Lsd1 knockout (KO) mouse ESCs. We show that CHD7 is dispensable for ESC self-renewal and survival, while Chd7 KO ESCs can differentiate towards embryoid bodies (EBs) with defective expression of ectodermal markers. Intriguingly, Chd7/Lsd1 double KO mouse ESCs exhibit proliferation defects similar to Lsd1 KO ESCs and have lost the capacity to differentiate properly. Furthermore, the increased co-occupancy of H3K4me1 and CHD7 on chromatin following Lsd1 deletion suggests that LSD1 is required for facilitating the proper binding of CHD7 to chromatin and regulating differentiation. Collectively, our results suggest that LSD1 and CHD7 work in concert to modulate gene expression and influence proper cell fate determination.
Reinforcement learning model for optimizing dexmedetomidine dosing to prevent delirium in critically ill patients
Authors: Lee Hong Yeul , Chung Soomin , Hyeon Dongwoo , Yang Hyun-Lim , Lee Hyung-Chul , Ryu Ho Geol , Lee Hyeonhoon 
Published: November 2024

AbstractDelirium can result in undesirable outcomes including increased length of stays and mortality in patients admitted to the intensive care unit (ICU). Dexmedetomidine has emerged for delirium prevention in these patients; however, optimal dosing is challenging. A reinforcement learning-based Artificial Intelligence model for Delirium prevention (AID) is proposed to optimize dexmedetomidine dosing. The model was developed and internally validated using 2416 patients (2531 ICU admissions) and externally validated on 270 patients (274 ICU admissions). The estimated performance return of the AID policy was higher than that of the clinicians’ policy in both derivation (0.390 95% confidence interval [CI] 0.361 to 0.420 vs. −0.051 95% CI −0.077 to −0.025) and external validation (0.186 95% CI 0.139 to 0.236 vs. −0.436 95% CI −0.474 to −0.402) cohorts. Our finding indicates that AID might support clinicians’ decision-making regarding dexmedetomidine dosing to prevent delirium in ICU patients, but further off-policy evaluation is required.
Aerodynamic Threshold Measures for Reflecting Glottal Closure in Voice Disorders
Authors: Chan Roger W. , Liu Sally Chien Hsin , Hsieh Li-Chun , Wu Chia-Hsin , Wu Xia , Xie Zhenyu 
Published: November 2024

Purpose:
Previous work suggested that phonation threshold pressure (PTP), phonation threshold flow (PTF), and phonation threshold power (PTW) could be effective aerodynamic measures for quantifying glottal incompetence. This study examined how these measures could reflect varying extent of incomplete glottal closure in individuals with voice disorders.

Method:
Thirty individuals formally diagnosed with glottal incompetence, including 10 with hypofunctional disorders (hypo group) and 20 with hyperfunctional disorders (hyper group), and 30 individuals with normal voice (control group) participated in the study. PTP was measured indirectly by intra-oral pressure during production of bilabial stop consonant–vowel syllables, PTF was measured during the sustained vowel /a/, and PTW was obtained as the product of PTP and PTF. The extent of incomplete glottal closure was quantified by normalized glottal gap (NGG) and normalized glottal gap area (NGGA) based on image analysis of videostroboscopic recordings of sustained /i/.

Results:

Significant differences in all threshold measures (
p
< .05) were found among three participant groups with medium-to-large effect sizes (η
p
2
= .128–.220), with significantly higher values for the hypo group than the control group and no significant differences between the hyper and control groups. Receiver operating characteristic (ROC) analysis showed the highest diagnostic or classification accuracy contrasting between the hypo and control groups (area under the ROC curve = .717–.757), with the highest classification accuracy for PTW. There were significant, moderate-to-strong positive correlations with NGG and NGGA for the disorders group (Pearson's
r
= .4244–.6226) and the hypo group (
r
= .5689–.8949).

Conclusions:
These measures could be effective for identifying glottal incompetence, especially for hypofunctional disorders. PTW could be more sensitive than PTP and PTF in reflecting the extent of incomplete glottal closure, consistent with theoretical predictions. Their relative sensitivities for quantifying distinct incomplete glottal closures specific to different voice disorders should be evaluated in future studies.
Winning the battle with cyber risk identification tools in industrial control systems: A review
Authors: Rotibi Ayo , Saxena Neetesh , Burnap Pete 
Published: November 2024

AbstractThe modern Industrial Control System (ICS) environment now combines information technology (IT), operational technology, and physical processes. This digital transformation enhances operational efficiency, service quality, and physical system capabilities enabling systems to measure and control the physical world. However, it also exposes ICS to new and evolving cybersecurity threats that were once confined to the IT domain. As a result, identifying cyber risks in ICS has become more critical, leading to the development of new methods and tools to tackle these emerging threats. This study reviews some of the latest tools for cyber‐risk identification in ICS. It empirically analyses each tool based on specific attributes: focus, application domain, core risk management concepts, and how they address current cybersecurity concerns in ICS.
Du gène à la cellule
Authors: Reynaud Dulaurier Robin , Brocard Julie , Rendu John , Debbah Nagi , Fauré Julien , Marty Isabelle 
Published: November 2024

Le dépistage génétique des maladies rares permet d’identifier le(s) gène(s) responsable(s) chez environ 50 % des patients. Les cas restants se trouvent dans une impasse diagnostique, car les connaissances actuelles ne permettent pas d’identifier le bon gène ou de déterminer si le(s) variant(s) détecté(s) sur le gène est(sont) pathogène(s) ou bénin(s). On parle alors de « variants de signification inconnue » (VSI). Dans le cas des maladies neuromusculaires, le gène RYR1 est souvent mis en cause, mais la majorité de ses variants identifiés sont classés comme VSI, ce qui met à mal le diagnostic précis des patients. Notre projet vise à créer un pipeline d’analyses en combinant différentes approches (l’intelligence artificielle, les données de biologies structurales et les analyses fonctionnelles), afin d’obtenir une classification des variants de RYR1 plus efficace et d’améliorer le diagnostic génétique des maladies liées à ce gène.
Parasport et maladies neuromusculaires
Authors: Lopez Orianne 
Published: November 2024

Les bienfaits de l’activité physique, sur le plan organique et psychologique, sont démontrés. Chez les patients atteints d’une maladie neuromusculaire, l’activité physique adaptée et le parasport sont aussi des moyens de lutter contre la sédentarité qui s’ajoute à celle imposée par la maladie.
Quelles que soient les capacités motrices du sujet, qu’il soit marchant ou non, qu’il ait une bonne force des membres supérieurs ou seulement une minime fonction distale préservée, un parasport peut être pratiqué. En effet, certaines disciplines sont possibles pour des patients aux fonctions motrices très faibles.
Une des missions des intervenants dans le parcours de vie de la personne atteinte d’une maladie neuromusculaire est d’aborder ce sujet. Il est capital de faire prendre conscience de ce champ des possibles et de son importance au patient, dès son plus jeune âge, et à ses aidants, tout en respectant d’éventuelles contre-indications ou inaptitudes partielles. Accompagner vers une pratique parasportive, c’est devoir « sortir de l’hôpital » et interagir avec des collaborateurs de proximité pour faciliter l’orientation, organiser l’initiation et la mise en place de l’activité dans le quotidien du patient.
Le temps accordé au patient et à ses aidants pour aborder ce sujet et les guider permet d’illustrer la prise en charge globale auprès de ce patient et le souci porté à son inclusion et à sa santé physique et mentale.
Modeling compartmentalization within intracellular signaling pathway
Authors: Alamichel Claire , Calvo Juan , Hingant Erwan , Latrach Saoussen , Quiblier Nathan , Yvinec Romain 
Published: November 2024

We present a novel approach to modeling receptor-activated signaling pathways that take into account the compartmentalization of receptors and their effectors, both on the cell surface and in dynamic intracellular vesicles called endosomes. The first building block of the model concerns compartment dynamics. It takes into account creation of de novo endosomes, i.e. endocytosis, and further recycling of endosomes to the cell surface or degradation, as well as fusion of endosomes via coagulation dynamics. The second building block concerns biochemical reactions on the cell surface and within intra-cellular compartments. Both building blocks are coupled by the transfer of molecules that occurs at each event that modifies the compartments.
The model is formulated as a integro-partial differential equation, with transport and coagulation operators, and source terms, coupled to an integro-differential equation. In this work, we prove sufficient conditions to obtain exponential ergodicity for the size distribution of intracellular compartments. We further design a finite volume scheme to simulate our model. Finally, we show two application cases that show qualitative agreement with recently published data, proving that our model can help capture the spatio-temporal complexity of receptor-activated signaling pathway.
Inflation des problematischen Moralisierens im
Stigmatisierungsdiskurs
Authors: Uhl Alfred , Wallroth Martin 
Published: November 2024

Zusammenfassung
Hintergrund und Fragestellung Die Fachwelt fordert seit Langem, die
Stigmatisierung von Menschen mit Substanzmissbrauch und Suchterkrankungen zu
beenden. Dabei wird oft auch gerechtfertigte Kritik oder Selbstkritik in ein
negatives Licht gerückt und der Diskurs stark moralisierend aufgeladen. Diese
Tendenzen bringen den Entstigmatisierungsdiskurs in Widerspruch zu Ergebnissen
der Suchtforschung und zu Erfordernissen der Suchthilfe und prävention.
Methoden Der Diskurs zum Thema und auch die Messung von Stigmatisierung
wird theoretisch analysiert.
Ergebnisse Im wissenschaftlichen Diskurs werden oft inhaltlich durchaus
angemessene Sicht- und Verhaltensweisen pauschal als unzulässig abgetan, was
bestehende Widersprüche nicht löst, sondern eher verstärkt. Das ist weder für
die primär Betroffenen noch für Dritte hilfreich.
Diskussion und Schlussfolgerung In einer modernen demokratischen
Gesellschaft ist es von zentraler Bedeutung, Toleranz gegenüber Menschen mit
Suchtproblemen oder anderen gesundheitlichen und sozialen Problemen zu fördern
und ihnen bei der Bewältigung ihrer Herausforderungen zur Seite zu stehen. Es
ist jedoch nicht sinnvoll, die Probleme, die Betroffene für sich selbst und ihre
Umgebung verursachen, trotz anderslautender Lippenbekenntnisse de facto zu
verleugnen und jede kritische Auseinandersetzung mit entstehenden Problemen als
„unzulässige Stigmatisierung“ zu brandmarken.
Direct Oral Anticoagulants: Quick Primer on When to Use and When to Avoid
Authors: Bejjani Antoine , Bikdeli Behnood 
Published: November 2024

AbstractDirect oral anticoagulants (DOACs) have transformed the landscape of antithrombotic therapy in the past two decades. However, there is uncertainty about when they should or should not be used for treatment or prevention of thromboembolic events. DOACs have largely replaced warfarin for many patients with atrial fibrillation or venous thromboembolism who require anticoagulant therapy. In addition to noninferior efficacy, fewer drug–drug and food–drug interactions and improved convenience; DOACs have been shown to reduce the risk of intracranial hemorrhage. They have also received new indications compared with warfarin, such as cardiovascular risk reduction in patients with stable atherosclerotic diseases. However, there are some scenarios in which DOACs are associated with inferior efficacy or worse safety compared with standard treatment, such as warfarin. These include patients with mechanical heart valves, thrombotic antiphospholipid syndrome, and others. Although DOACs offer a streamlined and convenient option for the management of many patients with or at risk of thromboembolic events, their use should be avoided in certain high-risk scenarios. This minireview summarizes such conditions and those in which there is uncertainty for use of DOACs for particular diseases or particular patient subgroups.
Unpredictable Aortic Behavior in Identifying Risk Factors for Reintervention: A Prospective Cohort Study
Authors: Eraqi Mohamed , Ghazy Tamer , Cerqueira Tiago , Leip Jennifer Lynne , Siepmann Timo , Mahlmann Adrian 
Published: November 2024

Abstract
Background Although advancements in the management of thoracic aortic disease have led to a reduction in acute mortality, individuals requiring postoperative reintervention experience substantially worse long-term clinical outcomes and increased mortality. We aimed to identify the risk factors for postoperative reintervention in this high-risk population.
Patients and Methods This prospective observational cohort study included patients who survived endovascular or open surgical treatment for thoracic aortic disease between January 2009 and June 2020. We excluded those with inflammatory or traumatic thoracic aortic diseases. The risk factors were identified using multivariate logistic regression and Cox proportional hazards regression models.
Results The study included 95 genetically tested patients aged 54.13 ± 12.13 years, comprising 67 men (70.53%) and 28 women (29.47%). Primary open surgery was performed in 74.7% and endovascular repair in 25.3% of the patients. Of these, 35.8% required one or more reinterventions at the time of follow-up (3 ± 2.5 years, mean ± standard deviation). The reintervention rate was higher in the endovascular repair group than in the open repair group. Among the potential risk factors, only residual aortic dissection emerged as an independent predictor of reintervention (odds ratio: 3.29, 95% confidence interval: 1.25–8.64).
Conclusion Reintervention after primary thoracic aortic repair remains a significant clinical issue, even in high-volume tertiary centers. Close follow-up and personalized care at aortic centers are imperative. In our cohort of patients with thoracic aortic disease undergoing open or endovascular surgery, postoperative residual dissection was independently associated with the necessity of reintervention, emphasizing the importance of intensified clinical monitoring in these patients.
Beyond homocolonialism: working towards queer decoloniality in Bangladesh
Authors: Hossain Adnan , Rahman Momin 
Published: November 2024

AbstractThe queer movement in Bangladesh suffered a crisis in 2016 with the murder of two activists, leading to an unwanted hyper-visibility in wider society, and a chilling effect on activism. We detail what it means to think beyond postcolonial critiques of international LGBTQ rights, briefly explaining the realities and limits of queer politics in Bangladesh, focusing on sexual health infrastructures and the emergence of legal citizenship for the “third-gender” hijra population. We argue that these dimensions of queer existence remain circumscribed, and that a public discourse of sexualities remains difficult to create as a terrain for equality. We explore whether the framing of ‘decolonial’ is useful here, conceptualized as a process of working through the postcolonial critique of western structures of financial and sexual frameworks, towards an understanding of crisis that requires reading colonialism in its later evolution in the context of nationalism, neoliberal development, and religious fundamentalism.
Individual language experience determinants of morphosyntactic variation in heritage and attriting speakers of Bosnian and Serbian
Authors: Tomić Aleksandra , Rodina Yulia , Bayram Fatih , De Cat Cecile 
Published: November 2024

Abstract
Using a causal inference approach, we explored the relationships among the language experience determinants of
morphosyntactic sensitivity, to identify the factors that indirectly and directly cause its acquisition or maintenance in
immigration contexts. We probed the sensitivity to Serbian/Bosnian clitic placement violations with a self-paced listening task,
in a diverse group of bilinguals in Norway (n = 71), born to immigrant parents, or having emigrated in childhood
or adulthood. The outcomes included a metalinguistic violation detection score and a listening/processing time difference between licit and
illicit structures.
Structural Equation Models revealed that literacy (as reading practices) was among the most influential
determinants of the ability to detect violations, while Bosnian/Serbian use across contexts and age of bilingualism onset
determined violation sensitivity in processing. We identified a significant threshold of societal language (SL) exposure at age 8.
Rather than SL exposure before this age precluding bilinguals from developing and maintaining morphosyntactic sensitivity, this
threshold seems to reflect a protective effect against attrition which intensifies the later after age 8 SL exposure starts. The
length of residence in Norway did not determine attrition, suggesting that heritage and attrited speakers should be considered on
a continuum rather than as distinct bilingualism profiles.