bluuebunny/crossref_metadata_2025_split huggingface dataset:
How various self-reported impairments influence walking ability in persons with late effects of polio
Authors: Brogårdh Christina , Lexell Jan 
Published: December 2024

BACKGROUND: Many persons with late effects of polio experience new or increased impairments, which can lead to walking limitations in daily life. No study has comprehensively analyzed how various self-reported impairments are associated with different aspects of self-reported walking limitations. OBJECTIVE: To determine the associations between self-reported impairments and self-reported walking limitations in persons with late effects of polio. METHODS: Three hundred and twenty-five persons (175 women and 150 men) with verified late effects of polio responded to the Self-reported Impairments in Persons with late effects of Polio (SIPP; 13-items) and to the Walking Impact Scale (Walk-12; 12 items). RESULTS: The overall correlation (rho) between the total sum scores of the SIPP and the Walk-12 was 0.61 ( p <  0.01). Of the 156 correlation coefficients (SIPP vs Walk-12), 151 (97% ) were significant at the 1% level. Self-reported muscle weakness, muscle fatigue, muscle and/or joint pain during physical activity and general fatigue had the strongest correlations (rho: 0.33 to 0.64) to the self-reported walking limitations, whereas memory difficulties, sleep disturbances and concentration difficulties had the weakest correlations (rho: 0.10 to 0.34). CONCLUSION: There are weak to moderate associations between self-reported impairments and walking limitations in persons with late effects of polio. By limiting the impact of those impairments that are strongest associated with walking, clinicians may improve walking ability. However, the strength of the associations implies that other rehabilitation interventions should be considered for improving overall performance in daily activities related to walking.
HADITH AL-MACHADI (1689-1770) AND HIS MANUSCRIPT COLLECTION
Authors: Abdulmajidov Ramazan S. , Anikeeva Tatiana A. , Shekhmagomedov Magomed G. 
Published: December 2024

This paper presents an overview of the private manuscript collection of Hadis al-Machadi (1689–1770), examined and partially digitized during the archaeographic expedition funded by the RSF grant No. 22-18-00295 “Electronic library of Arabic-language manuscripts from archival, library, museum and private collections of Russia” in the summer of 2023. The collection, notable for its thematic and chronological diversity, spans several centuries and encompasses materials in Arabic from various sources, including manuscripts directly associated with Hadis al-Machadi, those of his descendants, and other scholars from the village of Machada in the Shamilsky district of the Republic of Dagestan. Notably, the library includes works by Sufi authors and a significant corpus of letters, documents, legal records, and court decisions, offering fertile ground for further scholarly exploration. Among the manuscripts are rare or unique pieces such as “Silsilat al-masnuʻat” by Ahmad Zirikhgerani and “Hashiya ʻala Charpardi”. Moreover, the inclusion of works from the 19th and 20th centuries, likely acquired through the Gidatlin Ulama, underscores a tradition of continuity of Arab-Muslim studies in the region.
KIPCHAKS IN THE SOUTH CAUCASUS: AN EPISODE FROM THE BIOGRAPHY OF KHWARAZMSHAH JALAL AL-DIN MANGBURNI
Authors: Timokhin Dmitry M. 
Published: December 2024

In the composition of the 13th-century Persian historical work, “Tarikh-i Jahangushay,” authored by ʻAlaʼ al-Din Ata-Malik Juvaini and well-known among specialists, there exists a noteworthy episode within the narrative detailing the aggressive campaigns of Khwarazmshah Jalal al-Din Mangburni in the South Caucasus. This episode refers to the encounter between the Khwarezmians and the Georgian army. According to the Persian historian, the Georgian army, alongside other ethnic groups, included a detachment of Kipchaks numbering twenty thousand men. Prior to the battle, the Khwarazmshah dispatched an embassy to them, which, through persuasion, convinced the Kipchak detachment not to engage in combat with Jalal ad-Din and his forces but to withdraw from the battlefield. This diplomatic intervention significantly contributed to the victory of the Khwarezmian army. Although the episode from the text “Tarikh-i Jahangushay” is recognized by scholars, there has been a lack of dedicated research in global academia focused on analyzing the genesis of this narrative and its historical veracity. In our presented article, we not only endeavor to dissect Juvaini’s account concerning the Kipchaks and their involvement in the referenced battle between the Georgian army and the Khwarezmians, but also elucidate the interconnections between this narrative and other earlier and subsequent Arab-Persian historiographical works. The study highlights the migration of the Kipchaks to the South Caucasus region both before the Mongol period and during the 1220s, correlating reports of such migrations with Juvaini’s assertions. Among the most significant findings of our study is the alignment of the Persian historian’s narrative with historical realities, underscoring the distinctive rapport between the Khwarazmshah and the elite of the Kipchak tribal confederation, which had its roots in the pre-Mongol era.
MODERN MARRIAGE AND WEDDING RITUALS OF THE DARGINS-TSUDAHARS: TRADITIONS AND INNOVATIONS
Authors: Seferbekov Ruslan I. 
Published: December 2024

Based on field ethnographic material collected in the Levashinsky district of Dagestan in 2018 and 2022, using historical-comparative, typological, systemic, retrospective methods and the method of participant observation, the paper discusses the traditional and modern wedding ceremonies and customs of the rural population of one of the sub-ethnic groups of the Dargins – the Tsudahars1. This group has undergone the cultural influence of the Avars of the Gunibsky and Gergebilsky districts and the Laks of the Laksky district, which is reflected in interethnic marriage, the spread of Avar anthroponymy, Avar khinkal, Avar and Lak music, songs and dances among the Tsudahar Dargins. The rituals of the life cycle of the Tsudahars, as well as other Dagestanis and North Caucasians, were influenced by the sociocultural processes of the late 20th – early 21st centuries, associated with “perestroika”, a change in the paradigm of the state and social structure of Russia, another Russian modernization and urbanization, which directly or indirectly modified them. The study shows that, despite the influence of globalization and transformation processes, almost all the main stages, characters, rituals and customs of the traditional Tsudahar wedding were mostly preserved only in rural areas. Relics of early forms of religions and ancient forms of marriage are still found in the modern Tsudahar wedding. The custom of mutual assistance has fully preserved, which makes it possible to mitigate the burden of material expenses for the wedding. Since the beginning of the 90s of the 20th century and to date, the need to reduce financial costs and the growing influence of the Muslim religion have led to the popularization of non-alcoholic weddings and the holding of wedding mawlids, replacing traditional wedding rituals with religious ones. In our time, real conditions have been created for the revival of some of the lost original elements of the Tsudahar wedding. The preservation of most of the traditional elements of the modern Tsudahar wedding inspires certain confidence in the preservation of their ethnic and cultural identity in the era of globalization.
Delignification of Lignocellulosic Content of Sugarcane Bagasse (Saccarum officinarium) with Variations in Size and Pretreatment Time
Authors: Yusuf Andi Asdiana Irma Sari , Abadi Sakinah Islamiati , Sariwahyuni  
Published: December 2024

Sugarcane bagasse (Saccarum officinarium) is a byproduct of the sugar production process and holds potential as a raw material for bioethanol production due to its lignocellulose content. Lignocellulose contains important components such as cellulose, hemicellulose, and lignin. This study focuses on the delignification of sugarcane bagasse (Saccarum officinarium) through a combination of mechanical and autoclave treatments, with variations in particle size and heating time. The goal of this study is to reduce the lignin content and increase the proportion of cellulose and hemicellulose, key components for producing valuable products for instance bioethanol. In this research, sugarcane bagasse was processed with particle sizes of 60, 70, and 80 mesh, and heated in an autoclave for 30, 45, and 60 minutes. The Chesson-Datta method was used to analyze the lignocellulose content of the bagasse after the delignification process. The results showed that the best outcome was achieved with a particle size of 80 mesh and a heating time of 60 minutes, yielding the lowest lignin content at 14.27%, while cellulose and hemicellulose reached 44.3% and 26.75%, respectively. This indicates that variations in particle size and heating duration significantly affect the effectiveness of the delignification process. Optimizing these two parameters is crucial for increasing cellulose and hemicellulose content while reducing lignin. Further research is expected to develop more effective pretreatment techniques to enhance the efficiency of sugarcane bagasse biomass conversion for industrial applications
Crack Identification and Quantification of Bridge Concrete Based on YOLOX and Image Processing Techniques
Authors: Li Bixiong , Liu Yunjun , Kuang Guixing 
Published: December 2024

The investigation and analysis of bridge distress are critical for the assessment and maintenance of bridge safety, necessitating precise information regarding the condition of the bridge surface. In this study, a deep learning framework for automatically identifying bridge concrete cracks is proposed based on comparing the detection performance of YOLOX, SSD, and Faster R-CNN. The deep learning model YOLOX_s is initially trained and employed to identify bridge concrete cracks, and the detection results demonstrate that the bridge concrete crack identification accuracy rate of the YOLOX_s is 91.77% and much higher than that of SSD and Faster R-CNN, which are 88.09% and 86.57% separately. To perform bridge concrete crack quantification, several image processing techniques are applied. The process begins with the cropping of the identified cracks obtained by YOLOX_s followed by binarization using Otsu's method. Subsequently, the Zhang-Suen thinning algorithm is applied to extract the crack skeleton, while the Canny edge detection algorithm outlines the crack boundaries. Finally, a pixel accumulation-based method is implemented to calculate the crack dimensions. The findings indicate that the proposed method for measuring crack length and the maximum width achieves high accuracy levels of 96.6% and 95.86%, respectively.
Immune-checkpoint HLA-G gene polymorphisms, 3’-UTR types and their association with hepatocellular carcinoma and treatment response in Indian population
Authors: Nadda Neeti , Yadav Renu , Roy Neelanjana , Singh Nita , Kumar Sonu , Paul Shashi Bala , Gamanagatti Shivanand , Saraya Anoop , Shalimar  , Nayak Baibaswata 
Published: December 2024

BackgroundHuman leukocyte antigen-G (HLA-G) is a cancer-associated immune checkpoint protein implicated in tumor-driven immune escape mechanisms. This study was undertaken to determine genetic variations at the 3’-UTR of the HLA-G gene that may alter its expression, identify risk alleles and genotypes for their association with hepatocellular carcinoma (HCC), and treatment responses in the Indian population.ObjectivesCase-control genetic association study of HLA-G gene UTR polymorphisms with HCC and response to locoregional therapy (LRT).MethodsHCC cases (n = 100) and healthy controls (n = 110) were recruited for the genetic association study, of which 88 patients received LRT. Single nucleotide polymorphisms (SNPs) at the HLA-G 3’-UTR gene were genotyped by sequencing and PCR-RFLP. The genetic association of 14 SNPs with HCC and LRT responses was determined using population genetic approaches.ResultsThree of the 14 SNPs (rs1707, rs1710, and rs1063320) were found to be genetically associated with HCC risk and treatment responses. These three UTR SNPs are important for miRNA binding. We did not observe significant association of the most studied SNP, rs371194629 (INDEL, +2960), with HCC or treatment response. Serum sHLA-G levels were found to be significantly (p = 0.027) higher in HCC patients as compared to healthy controls. Highly prevalent UTR haplotypes in Indian HCC patients were UTR-4, -1, and -7 whereas in healthy controls it was UTR-3, and 15 as determined by a linkage disequilibrium (LD) plot using 8 SNPs.ConclusionHLA-G SNPs are genetically associated with HCC and treatment response. Haplotypes associated with high levels of HLA-G expression are more prevalent in HCC than in healthy controls.Core tipPopulation genetic approaches were used to study HLA-G gene polymorphisms in the Indian population for its genetic association with HCC risk, treatment response and altered gene expression. Out of the 14 SNPs studied for HLA-G UTR, three were linked to HCC and response to locoregional therapy. Linkage disequilibrium and UTR haplotyping analysis show that the UTR-4 haplotype linked to high HLA-G levels, is more common in HCC patients, while the UTR-3 haplotype, linked to low HLA-G levels, is more common in healthy controls. This study is the first to look at the UTR types based on HLA-G gene polymorphisms of Indian HCC patients and their response to therapy.
The use of a benign fast-growing cyanobacterial species to control microcystin synthesis from Microcystis aeruginosa
Authors: Lee Hakyung , Xu Vincent , Diao Jinjin , Zhao Runyu , Chen Moshan , Moon Tae Seok , Liu Haijun , Parker Kimberly M. , Jun Young-Shin , Tang Yinjie J. 
Published: December 2024

IntroductionMicrocystis aeruginosa (M. aeruginosa), one of the most abundant blue-green algae in aquatic environments, produces microcystin by causing harmful algal blooms (HABs). This study investigated the combined effects of nutrients and competition among cyanobacterial subpopulations on the synthesis of microcystin-LR.MethodsUnder varying nitrogen and phosphorus concentrations, cyanobacterial coculture, and the presence of algicidal DCMU, the growth was monitored by optical density analysis or microscopic counting, and the microcystin production was analyzed using high-performance liquid chromatography-UV. Furthermore, growth and toxin production were predicted using a kinetic model.Results and discussionFirst, coculture with the fast-growing cyanobacterium Synechococcus elongatus UTEX 2973 (S. elongatus) reduced M. aeruginosa biomass and microcystin production at 30°C. Under high nitrogen and low phosphorus conditions, S. elongatus was most effective, limiting M. aeruginosa growth and toxin synthesis by up to 94.7% and 92.4%, respectively. Second, this biological strategy became less effective at 23°C, where S. elongatus grew more slowly. Third, the photosynthesis inhibitor DCMU (3-(3,4-dichlorophenyl)-1,1-dimethylurea) inhibited M. aeruginosa growth (at 0.1 mg/L) and microcystin production (at 0.02 mg/L). DCMU was also effective in controlling microcystin production in S. elongatus–M. aeruginosa cocultures. Based on the experimental results, a multi-substrate, multi-species kinetic model was built to describe coculture growth and population interactions.ConclusionMicrocystin from representative toxin-producing M. aeruginosa can be controlled by coculturing fast-growing benign cyanobacteria, which can be made even more efficient if appropriate algicide is applied. This study improved the understanding of the biological control of microcystin production under complex environmental conditions.
NUF2 is associated with cancer stem cell characteristics and a potential drug target for prostate cancer
Authors: Zhang Dongxu , Liang Pu , Wang Qi , Xia Bowen , Yu Liqian , Hu Xiaopeng 
Published: December 2024

BackgroundCancer stem cells are characterized by self-renewal, clonal tumor initiation capacity, and treatment resistance, which play essential roles in the tumor progression of prostate cancer (PCa). In this study, we aim to explore the features of cancer stemness and characterize the expression of stem cell-related genes for PCa.MethodsWe downloaded RNA-seq data and related clinical information from The Cancer Genome Atlas (TCGA) database. The mRNA stemness index (mRNAsi) was analyzed for various clinical features, overall survival (OS), and disease-free survival (DFS), and a weighted gene co-expression network analysis (WGCNA) was performed to identify crucial gene modules and key genes, which may play a role in CSCs. The key gene functions were verified using multiple databases, including the TCGA and Gene Expression Omnibus database (GEO). Next, we explored the potential function of the modules and genes obtained using WGCNA using an enrichment analysis. Finally, we performed in vitro experiments for further verification.ResultsWe found that mRNAsi were higher in PCa tissues than in normal tissues, and the mRNAsi were closely related to the clinical characteristics of PCa. A total of 16 key genes associated with the mRNAsi scores were identified by WGCNA analysis, including NCAPG, NEK2, DLGAP5, CENPA, CENPF, TPX2, GTSE1, KIF4A, NEIL3, CDC25C, UBE2C, CDCA5, MELK, SKA3, NUF2, and BIRC5. These genes were explicitly highly expressed in PCa across TCGA cancers and were validated in 3 independent GEO PCa datasets. The functional annotations of the key genes were linked with the cell proliferation processes. NUF2 may be a potential biomarker for PCa. In vitro experiments showed that knockdown NUF2 reduced the proliferation and migration of PCa cells.ConclusionThe 16 key genes identified in this study significantly correlate with PCa stem cell characteristics and showed prognosis-oriented effects in PCa patients. Further, the NUF2 gene may be used as a drug target for treating PCa.
Mass balance, metabolic disposition, and pharmacokinetics of a single IV dose of [14C]CA102N in HT-29 xenograft athymic nude mice
Authors: Tchaparian Eskouhie , Lin Hua-Yang , Chen Yuchih , Hunter J. Neil , Yin Sindy , Ng Huey , Wu Albert 
Published: December 2024

IntroductionCA102N is a novel anticancer drug developed by covalently linking H-Nim (N-(4-Amino-2-phenoxyphenyl methanesulfonamide) to Hyaluronic Acid to target CD44 receptor-rich tumors. The proposed approach seeks to enhance the efficacy and overcome limitations associated with H-Nim, including poor solubility and short half-life.MethodsThe study aimed to evaluate the pharmacokinetics, biodistribution, metabolism, and tumor permeability of [14C] CA102N in xenograft mice following a single intravenous dose of 200 mg/kg. Liquid scintillation counting analysis was used for the pharmacokinetics and mass balance analysis. Metabolite profiling was assessed by HPLC-MS coupled with a radio flow-through detector. Quantitative Whole-Body Autoradiography was used to determine tissue distribution. Concentrations of CA102N and its metabolites were measured using total radioactivity data from urine, feces, and tissue samples.ResultsAbout 94.9% of the administered dose was recovered at 240 h post-dose. The primary route of radioactivity elimination was through urine, accounting for an average of 77% of the dose with around 13.2% excreted in the feces. Tissue distribution showed rapid accumulation within 0.5 h post-administration, followed by a fast decline in most tissues except for the tumor, where slow elimination was observed. CA102N/metabolites exhibited a two-phase pharmacokinetic profile, characterized by an initial rapid distribution phase and a slower terminal elimination, with a half-life (t1/2) of 22 h. The mean maximum concentration (Cmax) of 1798.586 µg equivalents per ml was reached at 0.5 h (Tmax). Most of the radioactivity in plasma was attributed to CA102N, while small-molecule hydrolysis products dominated the excreta and tissue samples. Metabolite profiling revealed two major hydrolysis products: H-Nim-disaccharide and H-Nim-tetrasaccharide. No unchanged [14C] CA102N was detected in urine or feces, suggesting that CA102N undergoes extensive metabolism before excretion.ConclusionThe current data provided valuable insights into the pharmacokinetics, metabolism, and tissue/tumor distribution of CA102N in mice. These findings demonstrated that metabolic clearance is the primary elimination pathway for CA102N and that the drug exhibits tumor retention, supporting its development as an anticancer therapy. Our results provided a strong pharmacological basis for the advancement of CA102N into the clinic.
Outage Probability Analysis and Altitude Optimization of a UAV-Enabled Triple-Hop Mixed RF-FSO-Based Wireless Communication System
Authors: Latka Deepika , Aggarwal Mona , Ahuja Swaran 
Published: December 2024

In this paper, we present the evaluation of network parameters for the unmanned aerial vehicle (UAV)-enabled triple-hop mixed RF/FSO-based wireless communication system, where one relay is a fixed relay and the second relay is a UAV which acts as decode-and-forward relay for communication from the base station (B) to the multiple mobile users (Mi), i∈{1,2⋯N}. The first hop from B to fixed relay (R1) is the radio frequency (RF) link modeled using α−κ−μ fading distribution, the second hop from the relay R1 to the UAV relay (R2) is a free space optics (FSO) link modeled using Gamma-Gamma fading, and the third hop from R2 to the Mi is, again, an RF link modeled using the Rayleigh fading model. The direct communication between the B and the Mi is not feasible due to the very large distance. We derive the closed form analytical expression for the outage probability of the proposed system and find the effect of the base system parameters on the performance of the system. We also analyze the outage probability of the system at high SNR values to get further insights of the system performance. In addition, altitude optimization of UAV is carried out to know the optimal elevation angle in correspondence with UAV’s optimal altitude in order to maximize performance of the system.
Evolução da patologia e tratamento fisioterapêutico no âmbito hospitalar na PDIC: um relato de caso
Authors: Panassol de Souza Giovana , Beraldo Ana Luiza , Fuchter Alessandra Cristina , Bonetti Karoline , Abramovecht Gustavo , Gonçalves Rosa Hellen , Hering Genske Juliana 
Published: December 2024

Introdução. A Polineuropatia Desmielinizante Inflamatória Crônica (PDIC) consiste em uma doença autoimune rara que acomete o sistema nervoso periférico. Objetivo. Proporcionar maior entendimento a respeito da evolução da patologia e da abordagem fisioterapêutica na PDIC. Relato de Caso. O presente relato de caso foi realizado através de prontuário físico e eletrônico. Paciente do sexo feminino com 36 anos de idade, permaneceu hospitalizada no Hospital Universitário do Oeste do Paraná por nove meses, no ano de 2008 com Síndrome de Guillain Barré (SGB) necessitando de ventilação mecânica com difícil desmame e traqueostomia, após a desospitalização permaneceu com sequelas motoras e dificuldade de deambular, tendo novo episódio de Síndrome de Guillain Barré em 2017. Após isso ocorreu vinte e quatro novas hospitalizações sendo diagnosticada com PDIC, devido as sequelas da patologia, a mesma realizou tratamento fisioterapêutico em todas as hospitalizações visando diferentes objetivos. Discussão. A Fisioterapia é fundamental, no tratamento da PDIC e da SGB, devido déficit de força muscular periférica e respiratória, afetando a funcionalidade e consequentemente a qualidade de vida. Além disso, a fisioterapia tem o objetivo de evitar o imobilismo em pacientes hospitalizados. Conclusão. A fisioterapia foi importante nos 17 anos de tratamento, visando o desmame ventilatório, melhora da funcionalidade pulmonar e motora.