bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aspectos técnicos y ambientes a nivel de pre-factibilidad para la producción orgánica sostenible de guapote (Parachromis Managuensis y P. Dovii) y almeja de agua dulce (Myce-topodidae), en Jiménez de Pococí, Limón, Costa Rica
Authors: Castro Méndez Adolfo 
Published: December 2018

El presente estudio para el desarrollo de una nueva empresa acuícola orgánica sostenible de nuevos productos no tradicionales, es creado para contribuir al desarrollo del cantón de Pococí y tratar de disminuir los impactos que ejercen varios problemas en esta zona así como en todo el país.
Entre los problemas que busca atacar, están la escasez alimentaria de calidad, la mala gestión en acuicultura, busca el ahorro y reciclaje del recurso hídrico y contrarrestar la excesiva explotación marítima actual, la reforestación con especies endémicas y/o en peligro de extinción y reintroducción de especies animales en peligro (principalmente acuáticos), así como de manera directa contribuir al rescate de ancianos en condiciones de abandono de la zona, mediante el apoyo a la Fundación Ángel de Amor, que realiza esta gestión en el cantón.
El documento en general completo elabora un detallado estudio de pre-factibilidad y viabilidad, desarrollando un análisis de mercado para la zona y un cliente principal que opera en todo el país (Corporación Automercado S.A), además de un análisis y estudios técnico, administrativo y organizacional, legal y como atributos principales, estudios ambiental, social, económico y financiero. Todos derivados de la creación de la empresa para evaluar y conocer los efectos de la futura organización.
Los resultados principales son que se tendrá una demanda insatisfecha debido al panorama que presentan los productos, ya que se determinó una gran aceptación y altas demandas, lo que técnicamente permite suplir a una parte del mercado investigado.
Ambientalmente la empresa cubre todas las exigencias y normativas relacionadas a la actividad, y más bien contribuye a la mejora y desarrollo ambiental, de fauna y flora gracias a las actividades, principalmente al solo utilizar agua de lluvia para la producción, sumado al uso de alta tecnología, biotecnología como M.E (microorganismos efectivos entre otros factores), implementación de HACCP (actividades de peligro y puntos críticos de control por sus siglas en inglés), Plan de Manejo Orgánico, BPA (buenas prácticas acuícolas), entre otras gestiones de calidad e inocuidad internacionales. Además de ser una empresa basada en códigos de ética, RSE (responsabilidad social empresarial), la mejora continua y buscar la superación y crecimiento de los colaboradores.
Cabe resaltar, que para el presente artículo, se desarrolla solamente algunos aspectos del estudio técnico y ambiental, análisis estrictamente ligado y directamente relacionado en el proyecto. Los resultados del estudio de mercado se dan por dados.
Estimación del efecto de la pendiente sobre el valor la tierra en la zona de La Damita, Cañón del Guarco, por medio del método econométrico de valuación
Authors: Paniagua Molina Javier 
Published: December 2018

Se realizó investigación en la zona de Cañón del Guarco, provincia de Cartago, para determinar el efecto de la pendiente sobre el valor de mercado de la tierra.
Una muestra fue seleccionada de tal forma que se tuviera variabilidad en cuanto a pendiente y tamaño de las tierras.
Un modelo económetrico fue seleccionado y ajustado para medir la relación entre las variables y se obtuvo resultados significativos para la pendiente y el tamaño de la tierra como variables explicativas del valor de la tierra.
Análisis de riesgo bajo simulación Monte Carlo para un proyecto de industrialización de carne de bovino
Authors: Paniagua Molina Javier 
Published: December 2018

Se realizó un análisis de riesgo mediante simulación Monte Carlo para un proyecto de establecimiento de planta de sacrificio de bovinos y porcinos en la Zona Norte de Costa Rica. Las variables de riesgo más sensibles fueron los precios de los boletos de sacrificio y la capacidad de uso de la planta para los primeros 4 años de operación. Las variables de respuesta del modelo de simulación fueron el VAN y la TIR y ambas en escenarios dinámicos de 1000 corridas de simulación resultaron muy similares a las obtenidas en el escenario estático. El coeficiente de variación para el VAN fue de 24,63% y para la TIR de 9,02%, asimismo en ninguno de los casos se obtuvo ninguna probabilidad de retorno negativo. Las medidas de riesgo anteriores sugieren que el proyecto presenta un riesgo medio representado por la variabilidad importante en los flujos, más sin probabilidad de obtener retorno negativo.
Valoración de empresa en marcha: El caso de un hotel en Costa Rica
Authors: Paniagua Molina Javier , Solano Alvarado Ricardo 
Published: December 2018

El objetivo del estudio fue determinar el valor de un hotel de gran trayectoria en Costa Rica, considerando el valor de los activos físicos como el terreno, las edificaciones, el mobiliario y el equipo, así como también el valor del negocio de hotelería.
Los resultados mostraron como el negocio de hotelería representa cerca de un 15% del valor del terreno, lo que indica que quizás deba replantearse la estrategia competitiva para mayor crear de valor de la empresa, o bien, el terreno deba utilizarse para otros usos alternativos comerciales.
Se espera que la metodología aquí expuesta pueda servir de guía para valoración de negocios hoteleros en el medio rural.
CHIMAMANDA NGOZI ADICHIE - UM MANIFESTO PARA EDUCAR CRIANÇAS FEMINISTAS
Authors: Calheiro Ineildes , Oliveira Eduardo 
Published: December 2018

Esse texto em forma de Resenha, trata de apresentar Chimamanda Adichie, autora do best-seller internacional Americanah, é feminista, negra, nigeriana nascida em Enugu, com obras publicadas desde 2008. Vive entre a Nígéria e os Estados Unidos devido a uma bolsa de estudos recebida pela MacArthur Foundation. Neste manifesto contendo quinze sugestões para criar filhos na perspectiva feminista, a autora adentra ao tema igualdade de gênero.
Irradiation of biological objects using an ionization beam in order to inhibit conditionally pathogenic and pathogenic microflora of agricultural raw materials
Authors: Zavyalov M. A. , Kuhto V. A. , Ilyuhina N. V. , Kolokolova A. Yu. 
Published: December 2018

The use of radiation technologies in agriculture and the food industry is a common worldwide trend. Global reduction of food products at all stages of production has reached 30 percent. Especially significant reduction is in fruits and vegetables production. Radiation treatment of food products helps to suppress the development of pathogenic microorganisms as a result it extends the storage periods. Despite numerous studies in this field, existing methods of irradiation require optimization in order to ensure the possibility of using irradiation for all types of fruit and vegetable products. This research work is focused on the study of the effectiveness of irradiation of model systems containing conditionally pathogenic microflora by electron beams with an energy of 10 MeV. The aim of these developments is to study the effectiveness of electron beam irradiation application to suppress pathogenic microorganisms that cause bacterial contamination of food products. In this regard, the following tasks were set: to determine the degree of investigated microorganism’s stability and to find the differences between horizontal and vertical positions of the samples during irradiation. The developments showed that Salmonella and E. coli strains were the most resistant to ionizing radiation, while S. aureus strains were less resistant. The difference of obtained results for vertical and horizontal positioning of the samples was noted. When processing samples with studied strains of cultures in the dose range from 4 to 5 kGy, there is an increase in the growth of microorganisms for all processing conditions. In the remaining studied ranges their inhibition are observed. It is important to take into account not only the effectiveness of the oppression of microflora on specific products, but also the efficiency of the installation for a specific sample.
PENINGKATAN KUALITAS PEMBELAJARAN MELALUI PENDEKATAN KONSTRUKTIVISTIK DALAM PENDIDIKAN BAGI ANAK USIA DINI
Authors: Sulthon Sulthon 
Published: December 2018

<p>Education is a conscious effort made by adults to change behavior more positive and meaningful. Behavioral changes need to hold a variety of serious and continuous efforts through meaningful learning. Meaningful learning will be able<br />to make changes concerning the behavior of cognitive, affective and psychomotor.<br />Learning which is able to achieve all of the three domains of educational objectives<br />is an active learning model that is performed to build their own knowledge through<br />teacher designed-learning activities. Constructivist learning is learning that is capable of changing the old style of teaching where the teacher is always an active role or be a style of teaching where the teacher as a facilitator who designed learning by activating his students to learn on their own, learn to interact in a responsible group for achieving learning outcomes individually, while he provides guidance and facilitates them to learn.</p>
Pain Management and Opioid Regulation: Continuing Public Health Challenges
Authors: Bonnie Richard J. , Schumacher Mark A. , Clark J. David , Kesselheim Aaron S. 
Published: December 2018

The still-growing US opioid epidemic lies at the intersection of two major public health challenges: reducing suffering from pain and containing the rising toll of harms associated with the use of opioids medications. Responding successfully to these challenges requires a substantial investment in surveillance and research on many fronts and a coordinated policy response by federal and state agencies and stakeholder organizations. A 2017 report of the National Academies of Sciences, Engineering and Medicine (NASEM) called for improved methods of measuring pain and the effects of alternative modalities of treatment as well as intensive surveillance of opioid-related harms; urged a long-term cultural transformation of how pain is perceived, assessed and treated; and outlined a comprehensive and balanced public health framework to guide Food and Drug Administration approval, monitoring, and review of opioids. We, authors of the NASEM report, use the articles published in this special section of AJPH as a platform for commenting on the public health burden of pain, the role of opioids in managing pain, global disparities in access to opioids for pain management, divergent approaches to opioid regulation, and the challenge of striking a reasonable balance between the needs of patients in pain and the prevention of opioid-related harms.
Nutritional counseling with or without mobile health technology: a randomized open-label standard-of-care-controlled trial in ALS
Authors: Wills Anne-Marie M , Garry Jamie , Hubbard Jane , Mezoian Taylor , Breen Christopher T , Miller Courtney Ortiz , Nalipinski Paige , Sullivan Stacey , Berry James D , Cudkowicz Merit , Paganoni Sabrina , Chan James , Macklin Eric A 
Published: December 2018

Abstract
Background: Nutritional status is an important prognostic factor in Amyotrophic Lateral Sclerosis (ALS). We wished to study the safety, tolerability and efficacy of nutritional counseling with or without an mHealth application to maintain or increase body weight in ALS, compared to standard care.
Methods: In this randomized open-label, standard-of-care-controlled, single-center clinical trial, we randomly assigned adults with ALS to one of three nutritional interventions: counseling by their physician or nurse (“standard care”), counseling by a registered dietitian (RD) (“in-person”), or counseling supported by a mHealth app (“mHealth”). Both intervention arms received tailored nutrition recommendations and recorded dietary intake and weight biweekly (mHealth) or monthly (in-person). The primary outcome of weight and secondary and tertiary outcomes of calorie intake, ALSFRS-R, and quality of life (QOL) were recorded at each clinic visit and analyzed in an ITT mixed model analysis.
Results: A total of 88 participants were enrolled of whom 78 were included in this analysis. The three arms were well-balanced except for excess males in the mHealth arm and greater weight lost at baseline in the in-person arm. Participants in the mHealth arm increased their calorie intake at month 3 to an average of 94% (95% CI: 85, 103) of recommended calories, compared to 81% (95% CI: 72, 91, p= 0.06 vs. mHealth) in the standard care arm. After 6 months, calorie intake and change in weight was not different among the three arms. QOL scores in the mHealth arm were stable over three months (0.3 points, 95% CI: -1.7, 2.2) compared to worsening in standard care (-2.1 points, 95% CI: -4.0, -0.2, p = 0.09 vs. mHealth), but all scores declined by six months. ALSFRS-R total scores declined by an average of -2.6 points (95% CI: -5.1, -0.1) over six months in the mHealth arm (p=0.13 vs. standard care) compared to -5.8 points (95% CI: -8.2, -3.4, p=0.74 vs. standard care) in the in-person and -5.2 points (95% CI: -7.6, -2.9) in the standard care arm.
Conclusions: Nutritional counseling is safe but did not increase weight compared to standard care in ALS patients.
Trial Registration: Clinicaltrials.gov identifier NCT02418546. Registered April 16, 2015.
Keywords: Amyotrophic Lateral Sclerosis, ALS, Neurodegenerative disease, mobile health technology, mHealth, nutrition, nutritional counseling, randomized controlled trial
Family based care program on the health status of hemiplegic patients with stroke: A Randomized Control Trial
Authors: Naderipor Arsalan , Faramarzi Hadith , Jalali Amir , Salari Nader , Rezaei Jahangir 
Published: December 2018

Abstract
Background: Stroke is a chronic disease requiring continuous and prolonged rehabilitation. A family-based care program can be an effective approach to rehabilitate these patients. This study aimed to determine the effect of family-based care program on the health status of hemiplegic patients with stroke.
Methods: In this clinical trial, 40 hemiplegic stroke patients were randomly selected as available and divided into two intervention and control groups. The patients care providers in the intervention group received the home-based care program in addition to routine care at the time of discharge, for four consecutive sessions of 50 to 60 min. This program then was performed by carers at home for four weeks. The patients in the control group received routine care during the discharge. The health status of patients in both groups was evaluated by health status questionnaire before beginning the program, and then one month after the end of the program. Data were analyzed using appropriate statistical tests in SPSS V.21.
Results: The results indicated that the difference between the mean scores of the health status of the two groups was not significant before the intervention; however, it was significant after the intervention (P< 0.05). Moreover, the mean scores after the intervention group were significantly higher than the pre-intervention, and the difference was not significant in the control group.
Conclusion: Providing home care training programs to family members and contributing them to patient care programs can increase self-care of the patients and improve their health status.
Keywords: Stroke; Hemiplegia; Nursing care; Family base care
Trial registration number and date of registration: IRCT2015070214333n38, 2015-08-28
The Effects of Different Shapes of Capsulorrhexis on Postoperative Refractive Outcomes and Effective Position of the Intraocular Lens in Cataract Surgery
Authors: Li Shixu , Hu Yiping , Guo Ran , Shao Yushuang , Zhao Jiangyue , Zhang Jinsong , Wang Jing 
Published: December 2018

Abstract
Background：To evaluate the effects of anterior capsular opening size on deviation from predicted refraction and the effective position of intraocular lens (ELP) in cataract surgery.
Methods：Eighty patients (80 eyes) with simple age-related cataracts were treated from May 2018 to September 2018 at the Fourth Affiliated Hospital of China Medical University. The patients were divided into 2 groups : 40 eyes were implanted with the C-loop haptic intraocular lens (AMO Tecnis ZCB00) while the other 40 eyes were implanted with the plate haptic intraocular lens (CT ASPHINA 509M). Follow-up visits were conducted postoperatively at 1 week, 1 month, and 3 months during which patients underwent refraction and data collection after pupil dilation that included anterior segment photography and Scheimpflug imaging by Pentacam. The area, horizontal and vertical diameter of the capsulorrhexis, circularity, decentration, and package were analysed using the image analysis software Image-Pro-Plus 6.0 that evaluated the relationship between the different shapes of capsulorrhexis with deviation from predicted refraction and ELP in cataract surgery.
Results: Deviation from predicted refraction and all of the parameters of capsulorrhexis were not correlative in the 509M IOL group, however, in the Tecnis IOL group, while the deviation from predicted refraction and all of the capsulorrhexis parameters were not correlative at 1 week, the deviation from predicted refraction did correlate with capsulorrhexis area,horizontal diameter at 1 month (P=0.029, P=0.048), and the capsulorrhexis area ,vertical diameter at 3 months (P=0.03, P=0.017).The ELP correlated with package in both groups postoperatively (r>0, P<0.05), but there is no other capsulorrhexis parameters correlate with ELP in the 509M IOL group (all P>0.05). For the Tecnis IOL group, the ELP and capsulorrhexis area were correlated at 1 week and 1 month, while the ELP and horizontal diameter, the ELP and vertical diameter were correlated at 1 week , but did not correlate with the other capsulorrhexis parameters in the Tecnis IOL group (all P>0.05).
Conclusions: The shape of the capsulorrhexis has an effect on postoperative refractive outcomes and the effective position of intraocular lens in cataract surgery, and plate haptic intraocular lenses have better refractive stability than C-loop haptic intraocular lenses.（ChiCTR-TRC-1800015638）
Improving pneumonia diagnoses using pulse oximetry at rural health institutions in South Ethiopia: Protocol for a cluster-randomized controlled trial
Authors: Hailemariam Solomon Tesfaye , Gebeyehu Yabibal , Loha Eskindir , Johansson Kjell Arne , Lindtjørn Bernt 
Published: December 2018

Abstract
Background: Hypoxemia is common in children with pneumonia. The World Health Organization and United Nations Children’s Fund developed the Integrated Management of Childhood Illness strategy for diagnosing pneumonia. But the strategy has limitations to accurately detect hypoxemia in children with severe pneumonia. This study will assess whether pulse oximetry improves health workers’ performance in diagnosing severe childhood pneumonia and whether the pulse oximeter is a cost-effective tool to improve diagnoses of severe pneumonia at primary health care units in South Ethiopia.
Methods: A cluster-randomized controlled trial will be conducted at 24 primary health care units in South Ethiopia from September 2018 to February 2019. The trial has two arms: the first arm will examine the combined use of the Integrated Management of Childhood Illness (IMCI) strategy with pulse oximetry, and the second arm will examine the use of the IMCI strategy alone. The study population will include children between 2 months and 59 month of age who present with cough or difficult breathing. The primary outcome of this trial is severe childhood pneumonia, as diagnosed via the IMCI guideline and pulse oximetry. Secondary outcomes will be referred cases of severe pneumonia, treatment failure on day 2, and cumulative treatment failure on days 5 and 14 after enrolment. A cost effectiveness study will be conducted simultaneously.
Discussion: This study will determine if using a pulse oximeter at health facilities in rural South Ethiopia improves diagnostic accuracy for paediatric severe pneumonia. Our secondary aim will be to evaluate if the benefit of pulse oximetry justifies its cost.
Trial registration: PACTR201807164196402 (14/06/2018). URL: https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=3466
Keywords: Integrated Management of Childhood Illness (IMCI), cluster-randomized controlled trial, pulse oximetry, childhood pneumonia, primary health care units, Ethiopia
Circular pOlyethylene drape in preVEntion of suRgical site infection (COVER Trial): Study protocol of a randomized controlled trial
Authors: Yoo Ri Na , Kim Hyung Jin , Lee Jae Im , Kang Won-Kyung , Kye Bong-Hyeon , Kim Chang Woo , Bae Sung Uk , Lee Joong Ho , Kang Byung Mo 
Published: December 2018

Abstract
Background: Surgical site infection (SSI) after abdominal surgery is still a significant morbidity associated with an increased socioeconomic burden and poor quality of life. SSI prevalence rates as high as 40% in cases of fecal contamination have been reported; however, current methods to reduce SSI are limited to elective abdominal surgery. Further evaluation of preventive measures for reducing SSI is necessary.
Methods/design: The COVER trial investigates whether the application of a dual-ring circular plastic wound protector reduces the rate of SSI in patients undergoing open abdominal surgery related to the gastrointestinal (GI) tract, regardless of the type of wound classified by the Center for Disease Control (CDC). The COVER trial is a multicenter, randomized controlled clinical trial with two parallel arms – one using a wound protector and the other using conventional surgical dressing gauze. The primary outcome will measure the rate of SSI in two groups. Statistical analysis of the primary end point will be based on the intention-to-treat population. The sample size is determined to achieve a study power of 80% at 95% 2-sided confidence limits. Considering a dropout rate of up to 5%, a total of 458 patients, 229 patients in each group, will be enrolled in this study.
Discussion: The COVER trial will provide high-quality evidence for using a circular polyethylene drape in open abdominal surgery for the GI tract in all types of wound. The design of the trial will deliver high external validity and clinical significance.
Trial registration: The trial protocol was registered at ClinicalTrials.gov (NCT 03170843) on May 31, 2017. https://clinicaltrials.gov/ct2/show/NCT03170843?term=NCT+03170843&rank=1
Keywords: Circular polyethylene drape, Abdominal surgery, Gastrointestinal tract, Surgical site infection, Randomized controlled trial