bluuebunny/crossref_metadata_2025_split huggingface dataset:
Day hospital versus intensive out-patient mentalisation-based treatment for borderline personality disorder: multicentre randomised clinical trial
Authors: Smits Maaike L. , Feenstra Dine J. , Eeren Hester V. , Bales Dawn L. , Laurenssen Elisabeth M. P. , Blankers Matthijs , Soons Mirjam B. J. , Dekker Jack J. M. , Lucas Zwaan , Verheul Roel , Luyten Patrick 
Published: February 2019

BackgroundTwo types of mentalisation-based treatment (MBT) have been developed and empirically evaluated for borderline personality disorder (BPD): day hospital MBT (MBT-DH) and intensive out-patient MBT (MBT-IOP). No trial has yet compared their efficacy.AimsTo compare the efficacy of MBT-DH and MBT-IOP 18 months after start of treatment. MBT-DH was hypothesised to be superior to MBT-IOP because of its higher treatment intensity.MethodIn a multicentre randomised controlled trial (Nederlands Trial Register: NTR2292) conducted at three sites in the Netherlands, patients with BPD were randomly assigned to MBT-DH (n = 70) or MBT-IOP (n = 44). The primary outcome was symptom severity (Brief Symptom Inventory). Secondary outcome measures included borderline symptomatology, personality functioning, interpersonal functioning, quality of life and self-harm. Patients were assessed every 6 months from baseline to 18 months after start of treatment. Data were analysed using multilevel modelling based on intention-to-treat principles.ResultsSignificant improvements were found on all outcome measures, with moderate to very large effect sizes for both groups. MBT-DH was not superior to MBT-IOP on the primary outcome measure, but MBT-DH showed a clear tendency towards superiority on secondary outcomes.ConclusionsAlthough MBT-DH was not superior to MBT-IOP on the primary outcome measure despite its greater treatment intensity, MBT-DH showed a tendency to be more effective on secondary outcomes, particularly in terms of relational functioning. Patients receiving MBT-DH and MBT-IOP, thus, seem to follow different trajectories of change, which may have important implications for clinical decision-making. Longer-term follow-up and cost-effectiveness considerations may ultimately determine the optimal intensity of specialised treatments such as MBT for patients with BPD.
Maturation of heart valve cell populations during postnatal remodeling
Authors: Hulin Alexia , Hortells Luis , Gomez-Stallons M. Victoria , O'Donnell Anna , Chetal Kashish , Adam Mike , Lancellotti Patrizio , Oury Cecile , Potter S. Steven , Salomonis Nathan , Yutzey Katherine E. 
Published: February 2019

ABSTRACT
Heart valve cells mediate extracellular matrix (ECM) remodeling during postnatal valve leaflet stratification, but phenotypic and transcriptional diversity of valve cells in development is largely unknown. Single cell analysis of mouse heart valve cells was used to evaluate cell heterogeneity during postnatal ECM remodeling and leaflet morphogenesis. The transcriptomic analysis of single cells from postnatal day (P)7 and P30 murine aortic (AoV) and mitral (MV) heart valves uncovered distinct subsets of melanocytes, immune and endothelial cells present at P7 and P30. By contrast, interstitial cell populations are different from P7 to P30. P7 valve leaflets exhibit two distinct collagen- and glycosaminoglycan-expressing interstitial cell clusters, and prevalent ECM gene expression. At P30, four interstitial cell clusters are apparent with leaflet specificity and differential expression of complement factors, ECM proteins and osteogenic genes. This initial transcriptomic analysis of postnatal heart valves at single cell resolution demonstrates that subpopulations of endothelial and immune cells are relatively constant throughout postnatal development, but interstitial cell subpopulations undergo changes in gene expression and cellular functions in primordial and mature valves.
An interview with Cassandra Extavour
Authors: Maartens Aidan 
Published: February 2019

ABSTRACT
Cassandra Extavour is Professor of Organismic and Evolutionary Biology and of Molecular and Cellular Biology at Harvard University (www.extavourlab.com). Recently appointed an editor at Development, her lab works on the evolution and development of germ cells in animals, the genetic control of reproductive capacity, and the evolution of the arthropod body plan. We met with Cassandra at the 2018 Santa Cruz Developmental Biology meeting and heard about her scientific history, her thoughts on the future of research at the intersection of evolution and development, and her lifelong passion for music.
Correlation analysis between the SUVmax of FDG-PET/CT and clinicopathological characteristics in oral squamous cell carcinoma
Authors: Zheng Dong , Niu Lixuan , Liu Wenpeng , Zheng Changgang , Yan Ruyi , Gong Liyan , Dong Zhongxing , Li Ke , Fei Jun 
Published: February 2019

Objectives: To investigate the relationship between maximum standardized uptake value (SUVmax) of 18F-FDG PET/CT and clinicopathological features of oral squamous cell carcinoma (OSCC), in order to formulate a better clinical guideline. Methods: In 104 patients with OSCC confirmed by pathology, there were 67 males and 37 females (age, 33–76 years; mean age, 56 years).18FDG, 18-fludeoxyglucose (18F-FDG) PET/CT manifestations and the clinicopathological features of the 104 patients were retrospectively analysed. Single-factor analysis and multiple regression analysis were conducted on possible factors influencing primary tumour SUVmax, including gender, age, smoking history, tumour location, tumour size, histological differentiation, TNM stage, T stage, N stage. Diagnostic performance of SUVmax for invading peri-tissue of OSCC was measured by the area under receiver operating characteristic curve, and sensitivity and specificity were determined at the Youdons index. Results: The single-analysis results showed that SUVmax was correlated with the histological differentiation, tumour size, TNM stage, T stage, N stage(p < 0.05), yet it was not correlated with gender, age, smoking history, tumour location (p > 0.05). Multivariate liner regression analysis showed that tumour size, TNM stage were influencing factors independent of primary tumour SUVmax (p < 0.05). Primary tumour SUVmax had predictive value for invading peri-tissue of OSCC. When the cutoff value was 7.98, the diagnostic efficiency was the highest, with the sensitivity being 90.0％ and the specificity being 76.2%. Conclusions: OSCC 18F-FDG PET/CT SUVmax is higher among patients with larger tumour size, poorer stage, and that primary tumour SUVmax is of important significance in predicting invading peri-tissue.
Pre-school aged children are exposed to Schistosoma through Lake Kivu in Rwanda
Authors: Rujeni Nadine , Mazimpaka Alex , Tumusiime Musafiri , Nyandwi Elias , Rutayisire Gad , Kayiranga Pascal , Umulisa Irenee , Ruberanziza Eugene , Osier Faith , Mutapi Francisca 
Published: February 2019

Background: Schistosomiasis is prevalent in many sub-Saharan African countries and transmission is through waters contaminated by infected snails. In Rwanda, although schistosomiasis is endemic, very few epidemiological studies exist; of these, schoolchildren have been the focus, neglecting pre-school-aged children (PSAC). Furthermore, malacological surveys to indicate the potential for transmission are scarce in the country. The aim of this study was to determine the prevalence of schistosomiasis among PSAC living on Nkombo Island in Lake Kivu and to map the distribution and infectivity of snails in the area. Methods: Stool and urine samples were collected from children aged 1 to 4 years and tested for schistosomiasis using the Kato Katz and the point-of-care circulating cathodic antigen (POC-CCA) diagnostic techniques respectively. Snails were collected along the shores at five different locations with human-water contact activities and cercaria shedding was microscopically examined. GPS receivers were used to collect geographical coordinates and snail distribution maps were generated using ArcGIS. A questionnaire was used to assess water contact activities and frequency. Results: A total of 278 PSAC were recruited. Overall, 9.5% (excluding traces) of the tested children reacted positively to the POC-CCA, although there were no ova detected in their stool via Kato Katz. The questionnaire revealed that 48.2% of parents/guardians use Lake Kivu’s water for household activities while 42.4% children are taken to the Lake shores daily. Overall, 13.5% of collected snails shed cercariae. Conclusions: PSAC of Nkombo Island are exposed to Schistosoma parasites through contact with Lake Kivu, which hosts a number of snails shedding cercaria. Exposure is through recreational activities but also through bathing as safe water is scarce in the area. Health education of parents/guardians of these young children should be promoted and the national schistosomiasis control program should be integrated into water supply projects.
The influence of a calcium sulphate bone void filler on the third-body damage and polyethylene wear of total knee arthroplasty
Authors: Cowie R. M. , Aiken S. S. , Cooper J. J. , Jennings L. M. 
Published: February 2019

Objectives Bone void fillers are increasingly being used for dead space management in arthroplasty revision surgery. The aim of this study was to investigate the influence of calcium sulphate bone void filler (CS-BVF) on the damage and wear of total knee arthroplasty using experimental wear simulation. Methods A total of 18 fixed-bearing U2 total knee arthroplasty system implants (United Orthopedic Corp., Hsinchu, Taiwan) were used. Implants challenged with CS-BVF were compared with new implants (negative controls) and those intentionally scratched with a diamond stylus (positive controls) representative of severe surface damage (n = 6 for each experimental group). Three million cycles (MC) of experimental simulation were carried out to simulate a walking gait cycle. Wear of the ultra-high-molecular-weight polyethylene (UHMWPE) tibial inserts was measured gravimetrically, and damage to articulating surfaces was assessed using profilometry. Results There was no significant difference (p  >  0.05) between the wear rate of implants challenged with CS-BVF (3.3 mm3/MC (95% confidence interval (CI) 1.8 to 4.8)) and the wear rate of those not challenged (2.8 mm3/MC (95% CI 1.3 to 4.3)). However, scratching the cobalt-chrome (CoCr) significantly (p < 0.001) increased the wear rate (20.6 mm3/MC (95% CI 15.5 to 25.7)). The mean surface roughness of implants challenged with CS-BVF was equivalent to negative controls both after damage simulation (p = 0.98) and at the conclusion of the study (p = 0.28). Conclusion When used close to articulating surfaces, a low-hardness, high-purity CS-BVF had no influence on wear. When trapped between the articulating surfaces of a total knee arthroplasty, CS-BVF did not scratch the surface of CoCr femoral components, nor did it increase the wear of UHMWPE tibial inserts compared with undamaged negative controls. Cite this article: R. M. Cowie, S. S. Aiken, J. J. Cooper, L. M. Jennings. The influence of a calcium sulphate bone void filler on the third-body damage and polyethylene wear of total knee arthroplasty. Bone Joint Res 2019;8:65–72. DOI: 10.1302/2046-3758.82.BJR-2018-0146.R1.
The effect of malalignment on proximal tibial strain in fixed-bearing unicompartmental knee arthroplasty
Authors: Danese I. , Pankaj P. , Scott C. E. H. 
Published: February 2019

Objectives Elevated proximal tibial bone strain may cause unexplained pain, an important cause of unicompartmental knee arthroplasty (UKA) revision. This study investigates the effect of tibial component alignment in metal-backed (MB) and all-polyethylene (AP) fixed-bearing medial UKAs on bone strain, using an experimentally validated finite element model (FEM). Methods A previously experimentally validated FEM of a composite tibia implanted with a cemented fixed-bearing UKA (MB and AP) was used. Standard alignment (medial proximal tibial angle 90°, 6° posterior slope), coronal malalignment (3°, 5°, 10° varus; 3°, 5° valgus), and sagittal malalignment (0°, 3°, 6°, 9°, 12°) were analyzed. The primary outcome measure was the volume of compressively overstrained cancellous bone (VOCB) < -3000 µε. The secondary outcome measure was maximum von Mises stress in cortical bone (MSCB) over a medial region of interest. Results Varus malalignment decreased VOCB but increased MSCB in both implants, more so in the AP implant. Varus malalignment of 10° reduced the VOCB by 10% and 3% in AP and MB implants but increased the MSCB by 14% and 13%, respectively. Valgus malalignment of 5° increased the VOCB by 8% and 4% in AP and MB implants, with reductions in MSCB of 7% and 10%, respectively. Sagittal malalignment displayed negligible effects. Well-aligned AP implants displayed greater VOCB than malaligned MB implants. Conclusion All-polyethylene implants are more sensitive to coronal plane malalignments than MB implants are; varus malalignment reduced cancellous bone strain but increased anteromedial cortical bone stress. Sagittal plane malalignment has a negligible effect on bone strain. Cite this article: I. Danese, P. Pankaj, C. E. H. Scott. The effect of malalignment on proximal tibial strain in fixed-bearing unicompartmental knee arthroplasty: A comparison between metal-backed and all-polyethylene components using a validated finite element model. Bone Joint Res 2019;8:55–64. DOI: 10.1302/2046-3758.82.BJR-2018-0186.R2.
We, the non-global citizens: Reflections on the possibilities and challenges of democratic global citizenship education in higher education contexts
Authors: Sant Edda 
Published: February 2019

AbstractThis article examines the possibilities and challenges of democratic global citizenship education (GCE) in higher education (HE) contexts. The article contrasts liberal, post-structuralist and postcolonialist theory with data deriving from a small empirical ethnographic project. A small group of undergraduate students studying education met weekly for a period of three months. Data were collected through field notes, course work and participants’ diaries. Results suggest that the global citizensubject, for these participants, is conceptualized as the cosmopolitan elites who do not identify themselves as national citizens. Global citizenship is constructed as an identity that students initially do not hold but aspire to gain. These findings pose some questions to democratic approaches to GCE.
George W. Bush as the “Man in the Arena”: Baseball, Public Memory, and the Rhetorical Redemption of a President
Authors: Butterworth Michael L. 
Published: February 2019

AbstractPresidential libraries and museums are important sites for understanding the rhetorical construction of presidential legacies in the United States. The newest of these institutions is the George W. Bush Presidential Center in Dallas, Texas. The museum assists in the rhetorical redemption of a historically maligned presidency, anchoring President Bush’s legacy in the virtues of masculine, authoritative leadership. This is aided in particular by a noteworthy focus on baseball as a mythic expression of American exceptionalism, most dramatically featured in a 2015 temporary exhibit called Baseball: America’s Presidents, America’s Pastime. Far from being simply a colorful metaphor for national identity, baseball celebrates Bush’s moral authority and links him to the legacy of previous presidents such as Theodore Roosevelt. In short, the exhibit makes clear that one cannot understand the Bush presidency without baseball.
Turbulence Characteristic of Flow Near Laboratory Experiment Groin Fields
Authors: Wardhana Pradipta Nandi 
Published: February 2019

Groin is hydraulic structure utilized to protect riverbank from erosion. Groin will shift away flow. Area just downstream of groin structure will be occupied by low velocity flow hence there will be sediment deposition. Turbulence mechanism between primary flow region and groin field having important role in sediment exchange needs to be investigated. Instantaneous flow measurement was conducted in order to investigate turbulence relation between series groin under various groin spacing. Laboratory experiment employed turbulence flow having Reynolds number range between 31,935-32,500 and Froude number range between 0.051-0.053. A MicroADV 16-MHz was used to measure 3D instantaneous velocity. The experiment findings expressed that Reynolds stress involving vertical velocity and did not show any specific distributions except at the lowest measurement elevation, while Reynolds stress showed specific distributions. Turbulence value difference between groin field and primary flow region at upstream of the groin field was significant. As the area was getting downstream, area containing high turbulence was wider. This work indicated that bed shear stress value tended to grow at downstream area of groin field. High difference bed shear stress value between primary flow region and groin field seized second groin field and third groin field.
Calcitonin measurement in pediatrics: reference ranges are gender-dependent, validation in medullary thyroid cancer and thyroid diseases
Authors: Eckelt Felix , Vogel Mandy , Geserick Mandy , Kirsten Toralf , Bae Yoon Ju , Baber Ronny , Schaab Michael , Thiery Joachim , Pfaeffle Roland , Raue Friedhelm , Kiess Wieland , Kratzsch Juergen 
Published: February 2019

Abstract

Background
There is only limited information on serum reference ranges of calcitonin (CT) in infants, children and adolescents. This gap hampers valid diagnostics in patients with multiple endocrine neoplasia type 2 (MEN 2) and planned prophylactic thyroidectomy. In addition, age-dependent reference ranges for CT are necessary to define a cure in medullary thyroid carcinoma (MTC). We asked whether the reference ranges for CT levels were age- and gender-dependent in the serum of a pediatric cohort.

Methods
A total of 6090 serum samples of 2639 subjects of the LIFE-Child cohort aged between 1 month and 17.9 years were analyzed by the CT electrochemiluminescence immunoassay (ECLIA). Reference intervals were estimated using the LMS method. For clinical validation the serum of 28 patients (61 samples) with MEN 2 and 106 patients (136 samples) with thyroid diseases were analyzed.

Results
CT levels showed a clear age- and gender-dependence with significantly higher values in boys (p<0.01). An accelerated decline of CT levels from newborn to children at the age of 4 and 5 years was observed for both sexes. A cure for MTC was demonstrated in 71% of MEN 2 patients after thyroidectomy, whereas 5 patients remained suspicious for micrometastasis or relapse. Only 1.5% of our patients with thyroid diseases revealed increased CT levels.

Conclusions
This is the largest study to establish novel pediatric reference ranges from the CT values of healthy subjects. It allows a precise laboratory monitoring of CT in pediatric patients with MEN 2. Thyroid diseases did not have a relevant influence on CT levels in our pediatric cohort.
Sulfate-reducing bacteria-assisted cracking
Authors: Wu Tangqing , Sun Cheng , Yan Maocheng , Xu Jin , Yin Fucheng 
Published: February 2019

Abstract
Field and laboratory studies have verified that sulfate-reducing bacteria (SRB) can assist in cracking, but there is no comprehensive review in literature related to this research. In this paper, a mini-review was done giving the available information on SRB-assisted cracking, including actual cases, laboratory investigations, thermodynamic interpretation, cracking mechanisms, and affecting factors. Furthermore, the existing problems were regularly extracted, and the possible development tendency prospected.
Kimura disease: a case report of a rare illness presenting as a common complaint
Authors: Rush Margaret L. , Mauro Alexandra , Bhansali Priti 
Published: February 2019

Abstract

Background
Kimura is an uncommon inflammatory cause of pediatric head and neck masses due to eosinophilic infiltration of unclear etiology. Kimura can present similarly to infectious lymphadenitis, a much more common pediatric complaint. This case explores the role of anchoring bias when faced with an illness that at first appears to fit a common illness script that led to a delayed diagnosis.

Case presentation
A 7-year-old boy presented with acute onset of pre-auricular lymphadenopathy and fevers initially thought to be most consistent with infectious cervical lymphadenopathy. Despite treatment with broad spectrum antibiotics and multiple evaluations for underlying abscess requiring surgical drainage, the patient did not improve and remained febrile. Eventually, excisional lymph node biopsy was obtained and a pathologic diagnosis of Kimura disease was made.

Conclusions
This case illustrates an uncommon pediatric diagnosis which presented similarly to infectious cervical lymphadenitis without additional laboratory features consistent with Kimura. We highlight the role of anchoring bias and care fragmentation leading to repeat imaging and delayed biopsy in the eventual diagnosis of a rare illness.
Was it you who died, or your brother?
Authors: Baldwin Hannah 
Published: February 2019

Abstract
This paper seeks to apply Christie Davies’ target theory to the classical jokebook Philogelos and more specifically, its most common protagonist, the scholastikos, whose central flaw is stupidity caused by his inability to interact with material reality, similar to modern “dotty professor” jokes. This paper seeks to build a model of how scholastikos jokes work, how the stereotype is constructed and perpetuated, how this differs from other “stupid” stereotypes used elsewhere in the Philogelos (largely ethnic-based stereotypes), and possible social and cultural anxieties bound up in the character of the scholastikos. It will explore the relationship between ancient and modern targets in light of Christie Davies’ target theory and extend this model of how humour functions to transhistorical case studies.
“I am I”: Self-constructed transgender identities in internet-mediated forum communication
Authors: Webster Lexi 
Published: February 2019

Abstract
This article analyses identity constructions and representations of self-identifying transgender individuals on a web-based forum. Although the forum is aimed towards all transgender users, the primary user-group are transfeminine users (intending on) undergoing medico-surgical interventions to align their physiology and identity. The data for this analysis are initial text posts from the forum board used for introductions (i.e. new users of the forum introducing themselves). The article assumes that introductions are the context in which one asserts key identity features; hence, this board is the most pertinent for analysing identity construction. In this article, I use a combination of corpus linguistics and Critical Discourse Studies tools to analyse the use of pronouns and gender-indexical nouns in identity constructions and the representation of social categorisations. This article is an attempt to demonstrate that transgender is not a collective homogeneous identity, and that gender-sex incongruence may not be a salient identity feature for some forum-users. I also examine the ideologies (re)produced in the local forum-communication discourse, and the evaluation of hegemonic practices within transgender discourse and wider gender discourse to further demonstrate the heterogeneity of transgender identity.