bluuebunny/crossref_metadata_2025_split huggingface dataset:
Educational Support Around Dialysis Modality Decision Making in Patients With Chronic Kidney Disease: Qualitative Study
Authors: Cassidy Brendan P. , Harwood Lori , Getchell Leah E. , Smith Michael , Sibbald Shannon L. , Moist Louise M. 
Published: October 2018

Background: Patients with chronic kidney disease (CKD) are asked to choose a renal replacement therapy or conservative management. Education and knowledge transfer play key roles in this decision-making process, yet they remain a partially met need. Objective: We sought to understand the dialysis modality decision-making process through exploration of the predialysis patient experience to better inform the educational process. Design: Qualitative descriptive study. Setting: Kidney Care Centre of London Health Sciences Centre in London, Ontario, Canada. Patients: Twelve patients with CKD, with 4 patients on in-center hemodialysis, home hemodialysis, and peritoneal dialysis, respectively. Measurements: Not applicable. Methods: We conducted semistructured interviews with each participant, along with any family members who were present. Interviews were transcribed verbatim. Conventional content analysis was used to analyze the transcripts for common themes. Representative quotes were decided via team consensus. A patient collaborator was part of the research team. Results: Three themes influenced dialysis modality decision making: (i) Patient Factors: individualization, autonomy, and emotions; (ii) Educational Factors: tailored education, time and preparation, and available resources; and (iii) Support Systems: partnership with health care team, and family and friends. Limitations: Sample not representative of wider CKD population. Limited number of eligible patients. Poor recall may affect findings. Conclusions: Modality decision making is a complex process, influenced by the patient’s health literacy, willingness to accept information, predialysis lifestyle, support systems, and values. Patient education requires the flexibility to individualize the delivery of a standardized CKD curriculum in partnership with a patient-health care team, to fulfill the goal of informed, shared decision making.
A preliminary investigation of parent-reported fiction versus non-fiction book preferences of school-age children with autism spectrum disorder
Authors: Davidson Meghan M , Ellis Weismer Susan 
Published: October 2018

Background & aims Anecdotal evidence suggests that individuals with autism spectrum disorder prefer non-fiction books over fiction books. The current study was the first to investigate parent-reports of children with autism spectrum disorder’s fiction and non-fiction book preferences and whether these relate to individual differences in social communication, oral language, and/or reading abilities. Method Children (ages 8–14 years, M = 10.89, SD = 1.17) with autism spectrum disorder diagnoses ( n = 19) and typically developing peers ( n = 21) participated. Children completed standardized measures of social communication, oral language, and reading abilities. Parents reported children’s current favorite book, and from these responses, we coded children’s fiction versus non-fiction book preferences. Main contribution Contrary to anecdotal evidence, children with autism spectrum disorder preferred fiction similar to their typically developing peers. Fiction versus non-fiction book preference was significantly related to social communication abilities across both groups. Children’s oral language and reading abilities were related, as expected, but the evidence for a relationship between social communication and reading comprehension was mixed. Conclusions This study provides preliminary evidence supporting the association of social communication in fiction versus non-fiction book preference, which may be related to children’s comprehension and support the theoretical role of social communication knowledge in narrative/fiction. Implications It should not be assumed that all children with autism spectrum disorder prefer expository/non-fiction or do not read narrative/fiction. Children who prefer non-fiction may need additional social communication knowledge support to improve their understanding of narrative fiction.
Three-dimensional seismic analysis of Late Paleozoic coal-bearing series reflections in the Hangjinqi, North Ordos Basin, China
Authors: Wu Xiaochuan , Pu Renhai , Wang Donghui , Deng Dong , Dong Machao 
Published: October 2018

The study of sand bodies and coalbeds that formed during strong events is conducive to understand the relationship between source rocks and reservoirs. Two sets of Late Paleozoic coal-bearing sequences including the Late Carboniferous Taiyuan Formation and Early Permian Shanxi Formation, with an accumulated thickness of more than a half wavelength (90 m), were deposited in the Hangjinqi region on the northern margin of the Ordos Basin. These strata appear as two peaks and two troughs, three peaks and three troughs in the 3D seismic data. We analyzed this coal-bearing seismic response through a combination of well-data statistical analysis, the establishment of forward modeling, and the creation of crossplots. The coal-seam thicknesses of the Taiyuan and Shanxi Formations and the spacing between the two sets of coal indicate the major roles in the merging and bifurcation of events. The formation of three peaks and three troughs requires that the thicknesses of the two sets of coal are greater than 2 m. The spacing between the two sets of coal must also exceed 10 m with a detectable lateral extension, which would otherwise generate two peaks and two troughs. The two peaks and two troughs indicate a combined relationship between the thin sandstones at the bottom of the Shanxi Formation and the thick coalbeds in the Taiyuan and Shanxi Formations. The three peaks and three troughs suggest a combined relationship between the thick sandstones at the bottom of the Shanxi Formation and the thin coalbeds in the Taiyuan and Shanxi Formations. The drilling results clarified that the well situated at the two peaks and two troughs regions is accompanied by higher gas productivity, revealing that the coal-seam thickness has a significant influence on gas accumulation. The presence of two peaks and two troughs indicates favorability for natural gas exploration.
Fluid Challenge During Anesthesia: A Systematic Review and Meta-analysis
Authors: Messina Antonio , Pelaia Corrado , Bruni Andrea , Garofalo Eugenio , Bonicolini Eleonora , Longhini Federico , Dellara Erica , Saderi Laura , Romagnoli Stefano , Sotgiu Giovanni , Cecconi Maurizio , Navalesi Paolo 
Published: October 2018

BACKGROUND:
Assessing the volemic status of patients undergoing surgery is part of the routine management for the anesthesiologist. This assessment is commonly performed by means of dynamic indexes based on the cardiopulmonary interaction during mechanical ventilation (if available) or by administering a fluid challenge (FC). The FC is used during surgery to optimize predefined hemodynamic targets, the so-called Goal-Directed Therapy (GDT), or to correct hemodynamic instability (non-GDT).

METHODS:
In this systematic review, we considered the FC components in studies adopting either GDT or non-GDT, to assess whether differences exist between the 2 approaches. In addition, we performed a meta-analysis to ascertain the effectiveness of dynamic indexes pulse pressure variation (PPV) and stroke volume (SV) variation (SVV), in predicting fluid responsiveness.

RESULTS:
Thirty-five non-GDT and 33 GDT studies met inclusion criteria, including 5017 patients. In the vast majority of non-GDT and GDT studies, the FC consisted in the administration of colloids (85.7% and 90.9%, respectively). In 29 non-GDT studies, the colloid infused was the 6% hydroxyethyl starch (6% HES; 96.6% of this subgroup). In 20 GDT studies, the colloid infused was the 6% HES (66.7% of this subgroup), while in 5 studies was a gelatin (16.7% of this subgroup), in 3 studies an unspecified colloid (10.0% of this subgroup), and in 1 study albumin (3.3%) or, in another study, both HES 6% and gelatin (3.3%). In non-GDT studies, the median volume infused was 500 mL; the time of infusion and hemodynamic target to assess fluid responsiveness lacked standardization. In GDT studies, FC usually consisted in the administration of 250 mL of colloids (48.8%) in 10 minutes (45.4%) targeting an SV increase >10% (57.5%). Only in 60.6% of GDT studies, a safety limit was adopted. PPV pooled area under the curve (95% confidence interval [CI]) was 0.86 (0.80–0.92). The mean (standard deviation) PPV threshold predicting fluid responsiveness was 10.5% (3.2) (range, 8%–15%), while the pooled (95% CI) sensitivity and specificity were 0.80 (0.74–0.85) and 0.83 (0.73–0.91), respectively. SVV pooled area under the curve (95% CI) was 0.87 (0.81–0.93). The mean (standard deviation) SVV threshold predicting fluid responsiveness was 11.3% (3.1) (range, 7.5%–15.5%), while the pooled (95% CI) sensitivity and specificity were 0.82 (0.75–0.89) and 0.77 (0.71–0.82), respectively.

CONCLUSIONS:
The key components of FC including type of fluid (colloids, often 6% HES), volume (500 and 250 mL in non-GDT studies and GDT studies, respectively), and time of infusion (10 minutes) are quite standardized in operating room. However, pooled sensitivity and specificity of both PPV and SVV are limited.
Contemporary Academic Contributions From Anesthesiologists in Adult Critical Care Medicine
Authors: Kiefer Jesse J. , Cartron Alexander , Galvagno Samuel , Mazzeffi Michael A. 
Published: October 2018

BACKGROUND:
Anesthesiology has a long relationship with critical care medicine (CCM). However, US anesthesiologists are less likely to practice CCM than non-US anesthesiologists. To date, no studies have compared academic contributions in CCM between US anesthesiologists and non-US anesthesiologists. The objective of our study was to use recent trends in critical care publications as a surrogate for academic contribution among US and non-US anesthesiologists.

METHODS:
Research articles published between 2010 and 2015 in 3 anesthesiology journals (Anesthesiology, Anesthesia & Analgesia, and British Journal of Anaesthesia) and 3 multidisciplinary CCM journals (Critical Care Medicine, Intensive Care Medicine, and Journal of Critical Care) were reviewed. Author information, including the primary department appointment and geographic location for the first and senior author(s), and article details, including topic and publication type, were collected. Odds ratios for having a first or senior author from the United States were calculated. Anesthesiologists’ contributions in individual journals were summarized, as were trends in anesthesiology CCM publications during the 6-year study period.

RESULTS:
A total of 3831 articles were reviewed, with 1050 (27.4%) having US authors. Eighty-two and one-half percent of CCM articles in anesthesiology journals had a US anesthesiologist as first author, and 81% had a US anesthesiologist as senior author, while fewer CCM articles in multidisciplinary journals had a US anesthesiologist as first (12.1%) or senior (12.3%) author. When considering all publications, 16.3% and 16.4% of articles had a US anesthesiologist as the first or senior author compared with articles for which non-US anesthesiologists were first (23.8%) or senior (20.9%) authors. The odds of having a US anesthesiologist as first or senior author compared to a non-US anesthesiologist for all publications were 0.6 (0.5–0.7) and 0.7 (0.6–0.9). The number of publications trended downward for both US anesthesiologists and non-US anesthesiologists during the study period.

CONCLUSIONS:
When compared to non-US anesthesiologists, US anesthesiologists had more CCM publications in anesthesiology journals and fewer publications in multidisciplinary CCM journals. The number of anesthesiology CCM publications decreased for both US and non-US anesthesiologists throughout the study period.
Needle lost in the haystack: multiple reaction monitoring fails to detect Treponema pallidum candidate protein biomarkers in plasma and urine samples from individuals with syphilis
Authors: Van Raemdonck Geert A. , Osbak Kara K. , Van Ostade Xaveer , Kenyon Chris R. 
Published: October 2018

Background:Current syphilis diagnostic strategies are lacking a sensitive manner of directly detectingTreponema pallidumantigens. A diagnostic test that could directly detectT. pallidumantigens in individuals with syphilis would be of considerable clinical utility, especially for the diagnosis of reinfections and for post-treatment serological follow-up.Methods:In this study, 11 candidateT. pallidumbiomarker proteins were chosen according to their physiochemical characteristics,T. pallidumspecificity and predicted abundance. Thirty isotopically labelled proteotypic surrogate peptides (hPTPs) were synthesized and incorporated into a scheduled multiple reaction monitoring assay. Protein extracts from undepleted/unenriched plasma (N = 18) and urine (N = 4) samples from 18 individuals with syphilis in various clinical stages were tryptically digested, spiked with the hPTP mixture and analysed with a triple quadruple mass spectrometer.Results:No endogenous PTPs corresponding to the eleven candidate biomarkers were detected in any samples analysed. To estimate the Limit of Detection (LOD) of a comparably sensitive mass spectrometer (LTQ-Orbitrap), two dilution series of rabbit cultured purifiedT. pallidumwere prepared in PBS. Polyclonal anti-T. pallidumantibodies coupled to magnetic Dynabeads were used to enrich one sample series; no LOD improvement was found compared to the unenriched series. The estimated LOD of MS instruments is 300T. pallidum/ml in PBS.Conclusions:Biomarker protein detection likely failed due to the low (femtomoles/liter) predicted concentration ofT. pallidumproteins. Alternative sample preparation strategies may improve the detectability ofT. pallidumproteins in biofluids.
Human Resource Management Practices in Turkish Education System (Denizli Case)
Authors: Cobanoglu Fatma , Sertel Gulsum , Seven-Sarkaya Sevda 
Published: October 2018

<p style="text-align:justify">Human Resource Management (HRM) includes recruitment, training, development, motivation and evaluation of the staff who will achieve the goals of the organization and perform the necessary activities to be successful. The success of the organization depends on the effective use and management of human resources. Considering that The Ministry of Turkish National Education has the most crowded personnel and the potential of leading the future human resources, the HRM strategies of this organization becomes significant. In this study, it is aimed to investigate to the human resources management practices of the Ministry of Turkish National Education from the perspectives of teachers who are also the human resources of the system. In this research, holistic-multiple case study design was employed and the open-ended interview form which includes nine questions considering the functions of the HRM was utilized as the data collection tool. Research results showed that teachers know the duties and responsibilities which are declared in their job definition but they do not consider some of the significant professional efficiencies such as planning, assessment and evaluation. Moreover, the ministry does not make long-term plans in order to determine the required human resources, and also the functionality and subjectivity of the system is under discussion in terms of selection and appointment. What's more, the desired aims cannot be reached in terms of professional development. Teachers have the anxiety of performance evaluation based on accountability, and they emphasize fair and subjectivity in terms of payment, rewarding and discipline.</p>
AVALIAÇÃO DA BIOSSEGURANÇA EM ESTABELECIMENTOS DE APLICAÇÃO DE MAQUIAGEM
Authors: Foppa Vanessa Cavanus , Tiecher Matias , Contri Renata Vidor 
Published: October 2018

O uso compartilhado de instrumentos em procedimentos estéticos pode resultar na contaminação tanto dos utensílios, quanto do cosmético que será utilizado em sua embalagem original, podendo ser fonte de transmissão de doenças. Este trabalho teve como objetivo avaliar o nível de informação que as maquiadoras possuem, utilizando a aplicação de um questionário, com relação às medidas de biossegurança inerentes às atividades realizadas, e também determinar a presença ou ausência de bactérias patogênicas em artigos utilizados em procedimentos de maquiagem, correlacionando os resultados encontrados com as respostas do questionário. Cinco estabelecimentos prestadores de serviços de maquiagem participaram da pesquisa, sendo que cada um forneceu dois artigos para aplicação de maquiagem, para tentativa de isolamento das bactérias Staphylococcus aureus e Pseudomonas aeruginosa. Além disso, cada estabelecimento apresentou um profissional maquiador para responder ao questionário com perguntas envolvendo biossegurança. Não houve crescimento das bactérias pesquisadas nas amostras analisadas; porém, uma delas apresentou desenvolvimento de colônias compatíveis com Staphylococcus epidermidis. Com relação ao questionário, algumas respostas dos profissionais apontaram não conformidades com a legislação, como a falta do uso de EPI, a falta de um local específico para limpeza do material, e a ausência do detergente enzimático na limpeza dos artigos de maquiagem, o que indica maior risco de contaminação. Não foram encontradas as bactérias de interesse nos artigos de maquiagem, apesar dos profissionais dos estabelecimentos responderem que não cumprem algumas medidas de biossegurança. Contudo, não está descartada a possibilidade de haver outras bactérias ou fungos potencialmente patogênicos presentes no material utilizado nos procedimentos.
AÇÃO DO ACETILHEXAPEPTÍDEO-3 NO PROCESSO DE REJUVENESCIMENTO FACIAL
Authors: Machado Karina Elisa , Sigales Geonara Leite , Solovy Ivanisse 
Published: October 2018

O envelhecimento é um processo multifatorial, resultado de diversos fatores, intrínsecos e extrínsecos. Consiste em um processo continuo que não afeta apenas a aparência, mas as diversas estruturas e funções da pele. Todo o organismo sofre com as alterações provocadas pelo envelhecimento, porém, é na face, uma das áreas mais foto exposta, que essas alterações são mais facilmente reconhecidas. A região facial envelhecida pode apresentar flacidez, rugas, linhas de expressão, entre outros distúrbios estéticos, que representam os sinais mais aparentes de uma pele senil. Na busca pela juventude, diversas técnicas de rejuvenescimento facial vêm sendo utilizado nos últimos anos, entre o quais acetilhexapeptídeo-3, um ativo de uso tópico que foi sintetizado com objetivo de mimetizar os efeitos da neurotoxina botulínica. Nesta perspectiva, o objetivo do presente trabalho foi analisar o processo de envelhecimento cutâneo e a ação do ativo acetilhexapeptideo-3 no processo de rejuvenescimento facial, por meio de uma revisão bibliográfica. O presente estudo caracterizou-se com uma revisão bibliográfica exploratória-descritiva com abordagem qualitativa, neste contexto buscou-se informações a respeito do processo de envelhecimento cutâneo e a ação do ativo acetilhexapeptídeo-3 no rejuvenescimento facial. Os resultados mostraram que o acetilhexapeptídeo-3, embora muito menos potente que a neurotoxina botulínica, promove melhoras significativas na aparência da pele envelhecida, justificando desta maneira seu uso em formulações cosméticas antienvelhecimento.
DIRETRIZES PARA ELABORAÇÃO DE UM PROTOCOLO E RELATÓRIO DE ESTUDO DE DEGRADAÇÃO FORÇADA DE MEDICAMENTOS DE ACORDO COM A RDC 53/2015
Authors: Da Costa Gabriel Nunes , Viana Gil Mendes , Lima Filho Ubiracir Fernandes , Cabral Lucio Mendes 
Published: October 2018

O estudo de degradação forçada (EDF) é uma atividade preditiva chave para conhecer a estabilidade de um insumo farmacêutico ativo (IFA) e do seu respectivo produto acabado. A partir dele, é possível obter um método indicativo de estabilidade pela realização de condições de estresse severas capaz de quantificar todos os degradantes possíveis no IFA ou no seu produto acabado. Os principais guias internacionais que tratam sobre o tema apenas dão uma visão geral sobre como realizar o EDF não fornecendo detalhes sobre uma abordagem prática destes estudos, o que dificulta uma padronização científica da metodologia. Com a publicação da RDC 53/2015 e do guia 04/2015 pela Agência Nacional de Vigilância Sanitária (ANVISA), as práticas internacionais de realização do EDF deverão ser revisadas para a obtenção de um registro de medicamento no Brasil. Portanto, este trabalho propõe um modelo de protocolo e relatório de EDF que atenda os requerimentos da legislação brasileira. Rota de degradação, condições de estresse, endpoints, percentual de degradação, balanço de massas, perfil de degradação potencial, validação analítica, identificação e qualificação de produtos de degradação foram discutidos ao longo deste trabalho. O modelo de protocolo e relatório apresentado atende a RDC 53/2015 em sua totalidade.
Persepsi dan Perilaku Wanita Usia Subur dalam Melakukan Tes Inspeksi Visual Asam Asetat
Authors: Sahr Liyasda Amalis , Kusumaningrum Tanjung Anitasari Indah 
Published: October 2018

Latar Belakang: Kabupaten Sukoharjo menempati sebagai salah satu kabupaten tertinggi positif IVA di Jawa Tengah dengan presentase sebesar 19.35%. Jumlah tersebut melampaui ambang batas yang ditetapkan oleh Kementerian Kesehatan RI yaitu sebesar 3%. Kunjungan tes IVA terendah terdapat di Puskesmas Kecamatan Sukoharjo yaitu hanya 47 (0,19%) wanita usia subur (WUS) yang telah tes IVA. Penelitian ini bertujuan untuk memahami perilaku WUS yang telah bersedia dan tidak bersedia melakukan tes IVA berdasarkan teori Health Belief Model. Metode: Jenis penelitian ini merupakan penelitian kualitatif dengan pendekatan studi kasus WUS yang bersedia dan tidak bersedia melakukan tes. Sebanyak 14 WUS terlibat dalam penelitian ini dan disertai dengan 14 suami WUS yang bersedia dilakukan wawancara mendalam sebagai teknik pengumpulan data. Satu orang bidan sebagai pelaksana program IVA tes juga di wawancara mendalam sebagai informan triangulasi. Hasil: Hasil penelitian menunjukkan bahwa sebagian besar WUS belum melakukan tes IVA. Persepsi hambatan yang dirasakan oleh WUS merupakan persepsi yang paling melatarbelakangi WUS tidak melakukan tes IVA. Alasan WUS enggan melakukan tes IVA karena kurangnya informasi tentang tes IVA sehingga WUS merasa tidak faham tentang IVA, selain kesibukan, perasaan takut, dan malu. Persepsi yang paling berkaitan dengan WUS melakukan tes IVA adalah cues to action. Alasan WUS melakukan tes IVA adalah karena mendapat sosialisasi lengkap sehingga faham manfaatnya, selain juga dukungan dari suami serta adanya contoh dari teman yang telah melakukan tes IVA.Kata Kunci: Kanker Serviks, Wanita Usia Subur, IVA, persepsi, Health Belief Model
Edukacja na rzecz zwierząt i ich praw. Uwagi w kontekście dyskursu o przemocy wobec zwierząt
Authors: Helios Joanna 
Published: October 2018

The purpose of this article is to present the issues of violence against animals. This text is educational in nature. Sometime in our society violence against animals is often marginalized. Humanitarianism and animal welfare are pushed into the background. It is therefore worth considering the causes of animal cruelty.