bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthetic Biology Open Language (SBOL) Version 2.3
Authors: Madsen Curtis , Goñi Moreno Angel , P Umesh , Palchick Zachary , Roehner Nicholas , Atallah Christian , Bartley Bryan , Choi Kiri , Cox Robert Sidney , Gorochowski Thomas , Grünberg Raik , Macklin Chris , McLaughlin James , Meng Xianwei , Nguyen Tramy , Pocock Matthew , Samineni Meher , Scott-Brown James , Tarter Ysis , Zhang Michael , Zhang Zhen , Zundel Zach , Beal Jacob , Bissell Michael , Clancy Kevin , Gennari John H. , Misirli Goksel , Myers Chris , Oberortner Ernst , Sauro Herbert , Wipat Anil 
Published: June 2019

AbstractSynthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. The field still faces substantial challenges, including long development times, high rates of failure, and poor reproducibility. One method to ameliorate these problems is to improve the exchange of information about designed systems between laboratories. The synthetic biology open language (SBOL) has been developed as a standard to support the specification and exchange of biological design information in synthetic biology, filling a need not satisfied by other pre-existing standards. This document details version 2.3.0 of SBOL, which builds upon version 2.2.0 published in last year’s JIB Standards in Systems Biology special issue. In particular, SBOL 2.3.0 includes means of succinctly representing sequence modifications, such as insertion, deletion, and replacement, an extension to support organization and attachment of experimental data derived from designs, and an extension for describing numerical parameters of design elements. The new version also includes specifying types of synthetic biology activities, unambiguous locations for sequences with multiple encodings, refinement of a number of validation rules, improved figures and examples, and clarification on a number of issues related to the use of external ontology terms.
Mental-Map Preserving Visualisation of Partitioned Networks in Vanted
Authors: Garkov Dimitar , Klein Karsten , Klukas Christian , Schreiber Falk 
Published: June 2019

Abstract
Biological networks can be large and complex, often consisting of different sub-networks or parts. Separation of networks into parts, network partitioning and layouts of overview and sub-graphs are of importance for understandable visualisations of those networks. This article presents NetPartVis to visualise non-overlapping clusters or partitions of graphs in the Vanted framework based on a method for laying out overview graph and several sub-graphs (partitions) in a coordinated, mental-map preserving way.
Inverse source problem for a distributed-order time fractional diffusion equation
Authors: Cheng Xiaoliang , Yuan Lele , Liang Kewei 
Published: June 2019

Abstract
This paper studies an inverse source problem for a time fractional diffusion equation with the distributed order Caputo derivative.
The space-dependent source term is recovered from a noisy final data.
The uniqueness, ill-posedness and a conditional stability for this inverse source problem are obtained.
The inverse problem is formulated into a minimization functional with Tikhonov regularization method.
Further, based on the series representation of the regularized solution, we give convergence rates of the regularized solution under an a-priori and an a-posteriori regularization parameter choice rule.
With an adjoint technique for computing the gradient of the regularization functional, the conjugate gradient method is applied to reconstruct the space-dependent source term.
Two numerical examples illustrate the effectiveness of the proposed method.
Tikhonov regularization with ℓ0-term complementing a~convex penalty: ℓ1-convergence under sparsity constraints
Authors: Wang Wei , Lu Shuai , Hofmann Bernd , Cheng Jin 
Published: June 2019

AbstractMeasuring the error by anℓ1{\ell^{1}}-norm, we analyze under sparsity assumptions anℓ0{\ell^{0}}-regularization approach, where the penalty in the Tikhonov functional is complemented by a general stabilizing convex functional. In this context, ill-posed operator equationsA⁢x=y{Ax=y}with an injective and bounded linear operatorAmapping betweenℓ2{\ell^{2}}and a Banach spaceYare regularized. For sparse solutions, error estimates as well as linear and sublinear convergence rates are derived based on a variational inequality approach, where the regularization parameter can be chosen either a priori in an appropriate way or a posteriori by the sequential discrepancy principle. To further illustrate the balance between theℓ0{\ell^{0}}-term and the complementing convex penalty, the important special case of theℓ2{\ell^{2}}-norm square penalty is investigated showing explicit dependence between both terms. Finally, some numerical experiments verify and illustrate the sparsity promoting properties of corresponding regularized solutions.
Relative age effects in American professional football
Authors: Heneghan Jack F. , Herron Michael C. 
Published: June 2019

Abstract
We test for the existence of relative age effects in professional American football. In a sample of 18,898 football players born on or after 1940, there is an excess of January and February births – consistent with a relative age effect associated with calendar year – as well as a slight increase in September births – consistent with the fact that some football players we analyze attended high school in states with fall school cutoff dates. We consider the possibility that relative age effects may affect skilled football positions more than positions relying heavily on player weight, and we find suggestive evidence of this. Lastly, and contrary to what has recently been shown in professional hockey, we find no evidence that misguided preferences for relatively older players lead to selection-based inefficiencies in football player drafting. Our results have implications for evaluating potential football players and speak broadly to the role of physiological factors beyond player control on athletic success.
Living a dog’s life: a putative gray wolf in a feral dog group
Authors: Popova Elitsa , Zlatanova Diana 
Published: June 2019

Abstract
The gray wolf and the domestic dog are closely related species that can interbreed and produce fertile offspring. In settings where unrestrained dogs are present in the wild, hybridization can happen naturally. However, the behavior of the resulting hybrids and their ecological impact is largely understudied. In September–November 2018, a putative gray wolf was repeatedly camera-trapped in a group of 10 presumably feral dogs in a remote mountainous area (the Osogovo Mountain) along the border between Bulgaria and North Macedonia. The most feasible explanation for this individual’s atypical behavior is that it is of hybrid origin (assumption based on phenotype). To the best of our knowledge, this is the first documented observation of such a kind. A discussion of its recruitment and position in the group is presented, setting the basis for further investigation of the complex interaction between wolves, dogs and hybrids in the wild.
Crystal structure of (Z)-6-(dimethylamino)-3,3-bis(4-(dimethylamino)phenyl)-2-(2-(quinoxalin-2-ylmethylene)hydrazinyl)-2,3-dihydroinden-1-one, C35H35N7O
Authors: Zeng Dai , Xing Ai-Ping 
Published: June 2019

Abstract
C35H35N7O, triclinic, P1̄ (no. 2), a = 10.2870(3) Å, b = 11.9918(4) Å, c = 13.8995(5) Å, α = 109.210(3)°, β = 96.833(3)°, γ = 107.594(3)°, Z = 2, V = 1497.32(9) Å3, R
gt(F) = 0.0401, wR
ref(F
2) = 0.1091, T = 110(1) K.
Crystal structure of bis[(2-(3-bromophenyl)-5-methyl-1,3-dioxane-5-carboxylato-κ-O)-(5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane-κ
4
N,N′,N′′,N′′′)]nickel(II), C40H60Br2N4NiO8
Authors: Tan Ying-Zhi , Jia Guo-Kai , Liu Xiao-Wen 
Published: June 2019

Abstract
C40H60Br2N4NiO8, triclinic, P1̄ (no. 2), a = 8.546(7) Å, b = 10.162(7) Å, c = 13.831(13) Å, α = 92.943(9)°, β = 101.096(8)°, γ = 111.710(5)°, V = 1085.1(15) Å3, Z = 1, R
gt(F) = 0.0317, wR
ref(F
2) = 0.0905, T = 296(2) K.
Crystal structure of 3-fluoro-3-methyl-1-((2-nitrophenyl)sulfonyl)-5,5-diphenylpiperidine, C24H23FN2O4S
Authors: Cai Zedong , Huang Xie , He Wei 
Published: June 2019

Abstract
C24H23FN2O4S, orthorhombic, Pbca (no. 19), a = 14.3646(18) Å, b = 15.5927(19) Å, c = 19.645(3) Å, V = 4400.1(10) Å3, Z = 8, R
gt(F) = 0.0349, wR
ref(F
2) = 0.0982, T = 296(2) K.
Galactosyl and sialyl clusters: synthesis and evaluation against T. cruzi parasite
Authors: Figueredo Andreza S. , de Andrade Peterson , Riul Thalita B. , Marchiori Marcelo F. , De Leo Thais Canassa , Fleuri Anna Karoline A. , Schenkman Sérgio , Baruffi Marcelo D. , Carvalho Ivone 
Published: June 2019

Abstract
The multivalent effect of carbohydrates (glycoclusters) has been explored to study important biological targets and processes involving Trypanosoma cruzi (T. cruzi) infection. Likewise, CuAAC cycloaddition reactions (click chemistry) have been applied as useful strategy in the discovery of bioactive molecules. Hence, we describe the synthesis of 1,2,3-triazole-based tetravalent homoglycoclusters (1–3) and heteroglycoclusters (4 and 5) of d-galactopyranose (C-1 and C-6 positions) and sialic acid (C-2 position) to assess their potential to inhibit T. cruzi cell invasion and also its cell surface trans-sialidase (TcTS). The target compounds were synthesised in good yields (52–75 %) via click chemistry by coupling azidosugars galactopyranose and sialic acid with alkynylated pentaerythritol or tris(hydroxymethyl)-aminomethane (TRIS) scaffolds. T. cruzi cell invasion inhibition assays showed expressive low parasite infection index values (5.3–6.8) for most compounds. However, most glycoclusters proved to be weak TcTS inhibitors at 1 mM (<17 %), except the tetravalent sialic acid 3 (99 % at 1 mM, IC50 450 μM). Therefore, we assume that T. cruzi cell invasion blockage is not due to TcTS inhibition by itself, but rather by other mechanisms involved in this process. In addition, all glycoclusters were not cytotoxic and had significant trypanocidal activity upon parasite survival of amastigote forms.
Numerical simulation and experimental investigation of multiphase mass transfer process for industrial applications in China
Authors: Yang Chao , Luo Guangsheng , Yuan Xigang , Chen Jie , Lu Yangcheng , Tang Xiaojin , Zeng Aiwu 
Published: June 2019

Abstract
This paper presents a comprehensive review of the remarkable achievements by Chinese scientists and engineers who have contributed to the multiscale process design, with emphasis on the transport mechanisms in stirred reactors, extractors, and rectification columns. After a brief review of the classical theory of transport phenomena, this paper summarizes the domestic developments regarding the relevant experiments and numerical techniques for the interphase mass transfer on the drop/bubble scale and the micromixing in the single-phase or multiphase stirred tanks in China. To improve the design and scale-up of liquid-liquid extraction columns, new measurement techniques with the combination of both particle image velocimetry and computational fluid dynamics have been developed and advanced modeling methods have been used to determine the axial mixing and mass transfer performance in extraction columns. Detailed investigations on the mass transfer process in distillation columns are also summarized. The numerical and experimental approaches modeling transport phenomena at the vicinity of the vapor-liquid interface, the point efficiency for trays/packings regarding the mixing behavior of fluids, and the computational mass transfer approach for the simulation of distillation columns are thoroughly analyzed. Recent industrial applications of mathematical models, numerical simulation, and experimental methods for the design and analysis of multiphase stirred reactors/crystallizers, extractors, and distillation columns are seen to garnish economic benefits. The current problems and future prospects are pinpointed at last.
Yeísmo in Majorcan Spanish: phonetic variation in a bilingual context
Authors: Rost Bagudanch Assumpció 
Published: June 2019

Abstract
This article addresses a particular characteristic of the variety of Spanish spoken in Majorca (Balearic Islands, Spain): the /ʎ/-/j/ merger (yeísmo). This island is home to a Catalan-Spanish bilingual community, meaning that Spanish speakers are in close contact with a system (Balearic Catalan) which is supposed to largely retain the /ʎ/-/j/ contrast. Given this context, our focus is to acoustically verify whether there is an interference from Balearic Catalan to Spanish in the sense of inhibiting yeísmo or, at least, favouring phonetic realisations other than those found in mainland Spanish. Our study concludes that a transfer in terms of allophonic variation does exist: in Majorcan Spanish lenited sounds ([i̯], [j]) are more common than in mainland Spanish.
Sull’origine della poesia romanza: ipotesi andalusa e mediolatina alla luce del rapporto fra rima e melodia
Authors: Di Santo Federico 
Published: June 2019

Abstract
Within the long-standing, and yet still lively debate over the origin of Romance poetry in general, and of regular rhyme in particular, one key element appears to have been often overlooked: music. Although it is very well known that Troubadour lyric poems were meant to be sung, their melodic form has so far indisputably been considered to be independent from the formal structure of the texts. However, a radical reconsideration of this common belief, based on a brand-new approach that takes orality into account, leads to the opposite conclusion that regular rhyme schemes, at their origins, were indeed closely related to the musical form of the songs. Linking rhymes to music may therefore represent a potentially decisive argument in the quest for the origin of Romance lyric poetry. For, even if rhymes and rhyme schemes may be found in many different and independent literary traditions, their structural relation to musical form is by far much rarer, hence offering a much more specific hint about the origin of Vernacular lyric forms, which are based on regular rhyme schemes. Tracing this metrical-musical technique back to its roots, may validate once and for all one of the two main theories competing around the origin of Vernacular lyric poetry, namely the Medieval Latin and the Andalusian Arabic theory.
The Role of Ferrotitanium as an Inoculant on the Microstructure and Mechanical Properties of Low-Alloy Steel
Authors: Mohammadaliha M. , Shahri F. , Boutorabi S. M. 
Published: June 2019

Abstract
In this work, the effects of ferrotitanium (0.5 wt.%) as an inoculant on the microstructure and mechanical properties of 0.24 % carbon-1 % chromium-1 % manganese-0.5 % silicon steel were studied. Optical microscopy and scanning electron microscopy (SEM) with energy dispersive spectrometry (EDS) microanalysis were used for microstructural investigations. The phase structure of the ferrotitanium-added alloys was studied using X-ray diffraction (XRD). Microstructural observations show that a fine upper bainite lath is formed and allotriomorphic ferrite is eliminated by adding ferrotitanium to the main alloy. XRD revealed the presence of ferrite and austenite in the microstructure. Also, a decrease in dendrite arm spacing (DAS) was observed for 0.5 wt.% ferrotitanium-added alloy. Addition of 0.5 wt.% ferrotitanium caused the formation of titanium-molybdenum-carbon precipitates in austenite grain boundaries so that these particles acted as nucleon’s in austenite grain boundary and refined the microstructure. The yield strength, ultimate tensile strength, and percent elongation to fracture of the ferrotitanium-added samples are increased by 65, 68, and 57 %, respectively. Finally, the fracture surface of the alloys showed a cleavage fracture for the inoculated alloy.
HOW AND WHEN IS SELF-EFFICACY RELATED TO ENTREPRENEURIAL INTENTIONS: EXPLORING THE ROLE OF ENTREPRENEURIAL OUTCOME EXPECTATIONS AND SUBJECTIVE NORMS
Authors: Santos Susana , Liguori Eric W. 
Published: June 2019

This study investigates how and when general self-efficacy is related to entrepreneurial intentions. We propose that entrepreneurial outcome expectations function as a mediator in this relationship, while subjective norms act as a moderator. Using a sample of 1052 students from U.S. Public Universities, we tested a moderated mediation model. Results showed that general self-efficacy is positively related to entrepreneurial intentions through the mediating effect of entrepreneurial outcome expectations, and that this relationship is significantly positive for individuals with favourable subjective norms towards entrepreneurship, while significantly negative for individuals with less favourable subjective norms. These findings contribute to literatures on entrepreneurial intentions. Keywords: entrepreneurial intentions, self-efficacy, entrepreneurial outcome expectations, subjective norms
Effect of smoking cessation on the parameters of microcirculation in arterial hypertension
Authors: Korneeva N V 
Published: June 2019

Aim. To identify changes of microcirculatory parameters in former hypertensive smokers.
Methods. Videobiomicroscopy was used to study the microcirculation of bulbar conjunctiva in 94 patients suffering from arterial hypertension. The results of former smokers (n=21, average age 41.6±2.5 years) were compared to those of smokers (n=32, average age 36.8±2.2 years) and non-smokers (n=41, average age 40.5±2.3 years).
Results. The average diameter of arterioles, the arteriolar-to-venular ratio and the average diameter of the capillaries were minimal in the group of smokers with hypertension. In former smokers, these indicators increased significantly (p1
Impact of aesthetic component of dental health on the quality of life of young patients
Authors: Lobach O I , Nikolenko V N , Lapina N V , Kochurova E V , Risovannaya O N , Skorikov V Yu 
Published: June 2019

Aim. To study the impact of the aesthetic component of dental health on the quality of life of young patients.
Methods. 83 subjects with violation of the aesthetics of hard tissues of the anterior group of teeth were examined and treated. Assessment of stability of composite restorations with materials of Russian and foreign production was carried out according to Ryge criteria. A brief questionnaire (the world health organization quality of life WHOQOL-BREF) was used to assess the quality of life.
Results. With the material Filtek Z550 violation of surface preservation occurred in 6 (15.8%) out of 38 men and only 1 (2.2%) out of 45 women (p=0.026). With Estelux NK material the violation of the seal surface preservation occurred in 5 (13.2%) out of 38 men and 2 (4.4%) out of 45 women, the findings are not statistically significant (p=0.15). The total index of quality of life in men and women significantly improved 6 months after the restoration and amounted to 88.7±5.4 points (p=0.024) and 88.4±7.3 (p=0.034), respectively, compared to test results prior to treatment. Stability of the quality of the restoration according to Ryge criteria of both photocomposite materials (Estelux NK and Filtek Z550) had no significant differences, therefore, the domestic material Estelux NK, taking into account its financial availability, can be recommended for aesthetic dental rehabilitation of young patients.
Conclusion. Restoration of the aesthetic optimum of men and women of young age leads to a subjective improvement of psychological comfort and objective increase of self-perception indices.
Barriers in providing tuberculosis services for people living with HIV and their overcoming
Authors: Zagdyn Z M 
Published: June 2019

Aim. To study the opinions of specialists in tuberculosis institutions on barriers and ways to improve the system fighting the spread of human immunodeficiency virus (HIV) and tuberculosis.
Methods. In the study questionnaires with open and closed questions were used among employees of tuberculosis facilities in four territories of the North-West Region of Russia (Saint-Petersburg, Leningrad, Arkhangelsk, and Kaliningrad oblasts) during six months in 2018. Total of 284 subjects were included. The questionnaire consisted of 19 structured questions. The respondents’ answers were compared interregionally and were analyzed integrally inside the blocks with the calculation of their ratios.
Results. According to the specialists’ opinion working in tuberculosis facilities, the main barriers to providing tuberculosis services for people living with HIV are low level of intersectoral interaction, migration, increase in the number of injecting drug users, lack of regional government support, inconsistency of regulation documents with the requirements of currant reality. As the main conditions for improvement of epidemic situation with association of HIV/tuberculosis, the respondents consider increasing administration of antiretroviral therapy to the patients with HIV, adequate treatment of tuberculosis in HIV-infection and raising awareness of HIV-infection and tuberculosis by the population.
Conclusion. To improve the existing system of fighting HIV/tuberculosis, strengthening the connection among the stakeholders may be possible, especially between tuberculosis facilities and detention centers giving the valuable access to antiretroviral therapy, chemoprophylaxis and tuberculosis treatment, including establishment of low-threshold centers, improved population awareness of tuberculosis and HIV-infection.
Experience of post-infarction left ventricular aneurysm reconstruction with on-pump beating heart technique
Authors: Tarasov D G , Chernov I I , Molochkov A V , Pavlov A V 
Published: June 2019

Aim. To evaluate the results of surgical treatment of post-infarction left ventricular aneurysms with on-pump beating heart technique.
Methods. In our center from April, 2009 to January, 2014 169 patients had reconstruction of the left ventricle with on-pump beating heart technique. Among the patients 159 were males (94.1%) and 10 of them were females (5.9%), average age 53.8±8.9 years (39 to 72 years). Angina pectoris class I (according to the classification of Canadian Heart Association) was established in 7 (4.1%) patients, class II - in 49 (29.0%), class III - in 107 (63.3%), class IV - in 4 (2.4%), unstable angina in 2 (1.2%) patients. Chronic heart failure class I (according to New York Heart association functional classification) was diagnosed in 5 (3.0%) patients, class II in 37 (21.9%), class III in 124 (73.4%), class IV in 3 (1.8%) patients. Average ejection fraction of the left ventricle was 38.6±7.9% (25 to 67%). Mitral valve insufficiency stage 2-3 was revealed in 23 (13.6%) patients.
Results. Endoventriculoplasty of the left ventricle by Dor's technique was performed in 49 (29.0%) patients, auto-septoplasty of the left ventricle - 59 (34.9%) patients, linear repair in 40 (23.7%) patients. Combined surgical interventions were performed in 21 (12.4%) patients. In-hospital lethality was 2.4% (n=4).
Conclusion. Left ventricular reconstruction with on-pump beating heart technique without cardioplegic arest is effective and safe; the method allows performing remodelling of the left ventricle and reaching the target volume parameters.