bluuebunny/crossref_metadata_2025_split huggingface dataset:
PHARMACOECONOMIC EVALUATION OF RIBOCICLIB FOR THE FIRST-LINE TREATMENT OF HR-POSITIVE HER2-NEGATIVE ADVANCED BREAST CANCER
Authors: Avksentyev N. A. , Zhuravleva M. V. , Pazukhina E. M. , Snegovoy A. V. , Frolov M. Yu. 
Published: August 2018

Background.Breast cancer is the most common malignant tumor and accounts for the most number of cancer-related deaths among Russian women. Combination of cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor ribociclib and aromatase inhibitor is approved for the first-line treatment of postmenopausal women with HR-positive HER2-negative advanced breast cancer.Objective:to conduct pharmacoeconomic evaluation of using ribociclib + aromatase inhibitor for the first-line treatment of HR-positive HER2- negative advanced breast cancer from the Russian healthcare system perspective.Materials and methods.The comparator was palbociclib + aromatase inhibitor, because ribociclib and palbociclib have similar mechanism of action and are the only available CDK4/6 inhibitors that could be used for treatment of HR-positive HER2-negative advanced breast cancer in Russia. Using clinical trials data and published results of matching adjusted indirect comparison (MAIC), we proposed Markov chain model of breast cancer progression and estimated direct medical costs associated with two considered options (first and subsequent lines of drug therapy, adverse events treatment, inpatient and outpatient care). Budget impact and cost-effectiveness analyses were conducted. Mean duration of treatment in the model was 21,9 and 20,2 months on ribociclib and palbociclib for five year time horizon respectively.Results and conclusion.Monthly medication costs of ribociclib (270 814.18 RUB) were 9 % less than for palbociclib (296 517.21 RUB). Driven by less monthly medication costs and potential of cost reduction due to dose reduction, five-year total medical per patient costs for ribociclib were 4 991 168 RUB, which were 1 162 666 RUB or 19 % less than for palbociclib. Ribociclib also had better (lower) cost/effectiveness ratio (1 244 906 vs 1 595 867 RUB per life year). As the result, ribociclib was considered a cost-saving option. If 8 162–8 270 women receive ribociclib, public healthcare expenditures will decrease by 20.1 billion RUB (21 %) within 3 years, compared to palbociclib.
Pengaruh Diversitas Dewan dan kinerja keuangan terhadap voluntary corporate disclosure
Authors: Aisyah Esy Nur 
Published: August 2018

<p>More disclosure can reduce agency costs incurred by the company. The more management (agent) reveal information about the company can reduce the conflict to shareholders (principal). Therfore, a voluntary disclosure more to minimize the occurence of information asymmetry. The more management companies disclose information about the incentives obtained become more, because basically shareholders (principal) would be willing to pay the cost of monitoring surveillance to prevent the hazard of the agent.</p><p>The aim of this study is to analyze and discribe how diversity influences gender and educational background of the board as well as the financial performance of the corporate voluntary disclosure. Definition councils in this study combines the board of commissioners and board of directors, because indonesia is adopting a two-tier system. The companies sampled is a company registered in the Indonesia Stock Exchange (IDX).</p>Adjusted R-squere value (0.55) shows that voluntary corporate disclosure nearly 55% depending on the independent variable is gender diversity of the board, board diversity educational backgrounds, profitability, size, liquidity and liverage of the company. Significance test showed that gender diversity and leverage are important determinants of corporate voluntary disclosure in Indonesia. On the other hand, the research also found that the variable gender diversity, provitability, size and liquidity is not strong explanatory variables to determine the extent of voluntary disclosure of company in Indonesia.
Sistem kemitraan usaha tani perspektif syariah (studi pada PT. BISI Internasional Kediri)
Authors: Zakiy Faris Salahuddin , Sari Indra Mustika , Sintia Kiki Debi 
Published: August 2018

<p>Sistem kemitraan juga telah diajarkan dalam nilai-nilai islam. Sehingga mengkaji secara mendalam tentang sistem kemitraan yang diterapkan oleh PT. Bisi Internasional Tbk. Dan dampaknya beserta ditinjau secara perspektif syariah sangat menarik dikaitkan dengan keadaan pertanian dewasa ini yang masih banyak permasalahan.</p><p>Jenis penelitian ini adalah penelitian kualitatif dengan pendekatan deskriptif dan <em>tracer study</em>. Data dan jenis data yang digunakan adalah data primer dan skunder. Pengumpulan data penelitian ini menggunakan metode observasi, wawancara, <em>tracer study</em> dan dokumentasi.</p>Hasil penelitian ini, bahwa sistem kemitraan yang diterapkan oleh PT. Bisi Internasional Tbk. Terdiri menjadi tiga bagian yaitu, sistem kemitraan murni, sistem kemitraan <em>green house</em> dan sistem kemitraan bagi hasil. Dan dampak yang didapatkan oleh para petani yaitu peningkatan pendapatan, kemudahan dalam mendapatkan modal, fokus dalam proses produksi, tempat distribusi yang terjamin dan bonus kualitas hasil panen. Sistem kemitraan yang diterapkan oleh perusahaan setelah dianalisis sesuai perspektif syariah, bahwa ada beberapa hal yang telah sesuai denganprinsip-prinsip syariah. Sistem kemitraan murni dna <em>green house</em> serupa dengan akad <em>muzaraah</em>namun belum sepenuhnya sesuai. Sedangkan sistem kemitraan bagi hasil sudah sesuai dengan akad <em>mukhabarah</em>
Hubungan antara ketaatan beragama dengan kinerja bisnis pengusaha di banjarmasin
Authors: Sadikin Abdurrahman Sadikin , Yusuf Satira Yusuf 
Published: August 2018

<p>Arikurtto, Suharsimi (1998) Prosedurr Penelitian, Suatu Pendekatan Praktek. Cetakan Kedua. Rineka Cipta, ]akarta.</p><p>Ajianuddin dalam makalahnya Pengembangan Usaha Kecil dan Menengah sebagai Salah Satu Upaya Pemulihan Perekonomian Indonesia.</p><p>Hisrich, R.D. &amp; Peters, N.P.,1998, <em>Entrepreneurship</em>, Fourth Ed., Irwin/McGraw- Hill. A Division of The McGraw-Hill Co,Missouri.</p><p>Hisrich, Robert D., 199l. "<em>Entrepreneurship/Intrapreneurship</em>", in: Staw, Barry M.,Psychological Dimensions of Organizational Behavior, International Ed., Maxwell MacMillan.</p><p>Jacobs, H., &amp; Kruger, S., 2001, <em>Establishing An Intrapreneurial Orientation As Strategy: A Framework For Implementation</em>, ActaCommercil, 1:l-11.</p><p>Perren, Lew, 2002, <em>Comparing Entrepreneurship and Leadership: A Textual Analysis,</em> Council for Excellence in Managernent and Leadership London.</p><p>Riduwan, 2002, Skala Pengukuran Variabel-Variabel Penelitian, Alfabeta, Bandung.</p><p>Radius Prawira dalam buku "Pengembangan dan Perlindungan Usaha Kecil" (1980;25) </p><p>Riyanti, Benedicta Prihatin Dwi, 2003, Kewirausahaan dari Sudut P andang Psikolagl, Grasindo, Iakarta.</p><p>Zimrnerer, Thomas W. &amp; Scarborough, Norman M.,1998, Pangantar Kewirausahaan dan Manajemen Bisnis Kecil, edisi Bahasa Indonesia, Prenhalindo, Jakarta.</p>
Classical and Modern Citizenship Concept in Islamic Perspective
Authors: Irfan Try Wiganda 
Published: August 2018

There are two concepts of Islamic citizenships, the Muslims and dhimmi. The concept of dhimmi citizenship is a non-Muslim citizen in the practice of country life received unequal preferential treatment, and different treatment is based on religious differences. In contrast to the concept of modern Islamic citizenship that gives equal treatment to all citizens regardless of religion. The concept of citizenship by the Messenger of Allah (peace and blessings of Allaah be upon him) in the city of Madinah al munawarah is the best citizenship concept of all time. Rasulullah shollallahu 'alaihi wasallam gives examples of the concept of the best citizenship that there are values of divinity, humanity, democracy and justice. The doctrine of the concept of citizenship of the Messenger of Allah sallallaahu 'alaihi wasallam is the concept of citizenship kosmpolitan.
Keywords: citizenship, dhimmi, rasulullah shollallahu 'alaihi wasallam, cosmopolitan
ABSTRAK
Konsep kewarganegaraan Islam terdapat dua, yaitu muslim dan dhimmi. Konsep kewarganegaraan dhimmi adalah warga negara non muslim dalam praktik kehidupan negara mendapat perlakuan istimewa yang tidak sama, dan perlakuan berbeda didasarkan karena perbedaan agama. Berbeda dengan konsep kewarganegaraan Islam modern yang memberikan perlakuan yang sama kepada semua warga tanpa membedakan agama. Konsep kewarga-negaraan yang diterapkan oleh Rasulullah shollallahu 'alaihi wasallam di kota Madinah al munawarah merupakan konsep kewarganegaraan yang terbaik sepanjang masa. Rasulullah shollallahu 'alaihi wasallam memberikan contoh konsep kewarganegaraan terbaik yang terdapat nilai-nilai ketuhanan, kemanusiaan, kerakyatan serta keadilan. Ajaran konsep kewarganegaraan Rasulullah shollallahu 'alaihi wasallam merupakan konsep kewargane-garaan kosmpolitan.
Kata kunci: kewarganegaraan, dhimmi, Rasulullah shollallahu 'alaihi wasallam, kosmopolitan
Trejo Nieto, Alejandra (2017). Localización manufacturera, apertura comercial y disparidades regionales en México. Organización económico-espacial bajo un nuevo modelo de desarrollo. Ciudad de México: El Colegio de México, A. C.
Authors: Mercado Celis Alejandro 
Published: August 2018

Comentarios al libro Localización manufacturera, apertura comercial y disparidades regionales en México. Organización económico-espacial bajo un nuevo modelo de desarrollo, de Alejandra Trejo
Acute masticatory muscle compartmental syndrome in a dog
Authors: Cray Megan T. , Spector Daniel I. , West Chadwick L. 
Published: August 2018

Abstract
CASE DESCRIPTION A5.5-year-old sexually intact male Bull Terrier was referred for evaluation because of sudden facial swelling and an inability to close its mouth.
CLINICAL FINDINGS Physical examination revealed bilaterally elevated nictitating membranes, an inability to adduct the mandible without assistance, and severe, diffuse, firm masticatory muscle swelling. Computed tomographic examination of the head revealed symmetric bilateral enlargement of the temporalis, masseter, and pterygoid muscles with heterogeneous contrast enhancement. Intracompartmental pressures in the left and right temporalis muscles as measured with an invasive arterial blood pressure transducer were 72 and 96 mm Hg, respectively.
TREATMENT AND OUTCOME Emergent fasciotomy of the temporalis and masseter muscles was performed, followed by medical management with corticosteroids and analgesics. The diffuse facial swelling resolved within 1 week after surgery. Results of serologic testing for antibody against masticatory 2M muscle fibers were negative. Results of histologic examination of temporalis muscle specimens were consistent with mild to moderate multifocal neutrophilic and histiocytic myositis with myofiber degeneration and necrosis.
CLINICAL RELEVANCE Acute compartmental syndrome should be considered as a differential diagnosis for dogs with a sudden onset of severe skeletal muscle swelling, signs of pain, and dysfunction. Findings for this dog with acute compartmental syndrome isolated to the masticatory muscles suggested that emergent fasciotomy followed by medical management may be an effective technique for treatment of this rare disease in dogs.
Identification and evaluation of criteria for selecting contractors using a risk management approach
Authors: Mousakhani Ehsan , Ranjbar Shirzad , Ashoori Taha 
Published: August 2018

Abstract
Transferring all or some parts of the engineering activities or supply of goods to third persons or companies is one of the adopted methods that transfer a significant part of the likely risks to the concerned side. Out­sourcing activities are followed by many benefits, such as reducing overhead and operational costs, increasing efficiency, reducing risk, and so on; however, if this is not done carefully, not only is no benefit gained, but also new risks are imposed on the organization. Considering that waste of time and cost diversions of projects stem from the selection of inappropriate contractors, risk assessment is important in outsourcing. Using a risk-oriented approach based on software toward outsourcing, the present study aims to identify and rate the factors affecting the selection of contractors and to finally provide a method to evaluate and select the proper way for the selection of contractors. This method is not just based on the lowest price, but it also includes several factors that influence the selection of contractors, which is achieved by applying the Expert Choice software. At first, the most important risk factors in the selection of contractors were identified according to the conducted research. Then, the factors that had the greatest risk potential for achieving the project goals were chosen from among them. The opinions of experts were obtained in the next phase to determine the importance of various factors in the process of contractor selection, which was achieved by the distribution of a questionnaire. Subsequently, the most important factors chosen by the experts were specified, and their relationship with the contractor’s risk management was found.
Novel Converter for Voltage Balance in Series-Connected Capacitors and Batteries
Authors: Hachlowski Jakub , Stala Robert 
Published: August 2018

Abstract
This paper presents a novel concept of a circuit for voltage balance of three series-connected capacitors or batteries, as well as the research results. The problem is related to the control of voltage sharing on series capacitors, supercapacitors or battery banks in energy storage systems or direct current (DC)-link of four-level neutral-point-clamped inverters. The proposed circuit is a switched-capacitor (SC) resonant converter composed of a single capacitor and seven transistor switches. Control of the converter makes it possible to transfer energy between any capacitors, by switching selected transistors. This paper presents the basic concept of the converter, an analysis of control strategies and the simulation results for various cases of voltage balancing.
Year 1948: Emancipation of Women and Slovak Theatre.
Authors: Lindovská Nadežda 
Published: August 2018

Abstract
From the cultural and art point of view, the year 1948 in Czechoslovakia was not just the so-called “Victorious February” of the working people. The remarkable phenomenon of this era, which was related to the post-war political and social movement, was the phenomenon of female emancipation and feminization of the stage production. During the two consecutive theatre seasons 1947/1948 and 1948/1949, at The New Scene Theatre of the National Theatre in Bratislava, several women, led by the director Magda Husaková-Lokvencová created several productions. For the first time, a sovereign feminine alliance had emerged in our performance art, proving that conceptual and thoughtful theatrical production may not be just the domain of men. These women contributed to deconstructing the beliefs of typically male and typically female professions as well as transforming traditional views of the role and position of both sexes in society and the arts. The attention of theatre historiography in the recapitalization of the impacts of the breakthrough events of the Czechoslovak post-war politics of the forty years on cultural events so far focused mainly on the issues of dramaturgy and poetics, the process of ideological transformation and the sovietisation of art in the spirit of socialist realism. The subject of socialist emancipation and theatre was at the edge of the interest of our theatrology. Ten years ago, a collective monograph, dedicated to the first lady of the Slovak theatre directors, Magda Husaková-Lokvencová, managing to free her forgotten personality and work and return her to the context of Slovak theatre history in the second half of the 20th century. There is still room for further research, complementing the knowledge and reflection of the advent of women in the sphere of theatre directory, dramaturgy and scenography artwork, as part of the history of gender relations in Slovakia. Increased interest in the history of women provokes a new reflection on the issue of emancipation and theatre.
Theatre As Architecture of Memory and National Identity. Russian Case – Golden Mask 2018
Authors: Spodniaková Zuzana 
Published: August 2018

Abstract
The author focuses on selected productions of this year’s special program category of the Russian Theatre Festival Golden Mask 2018 – Russian Case in Moscow. The comparison of the latest productions of different genres and artistic aesthetics reveals the common interest of their creators in urgent socio-cultural and historical-political themes. The Russian Case category introduced Russian theatre this year as an increasingly active tool for social engagement, which is concerned with the present or the past of the nation or individual. With the vision of a better future, creators confront themselves with collective and individual memories and seek ways to cope with them in an artistic and human way.
Statecharts estocásticos para evaluación del desempeño en los sistemas reactivos
Authors: Chica Leal Alonso de jesus , Cano Mendoza Diego Fernando 
Published: August 2018

Las cartas de estado (Statecharts) son representadas en un leguaje gráfi co para identifi car sistemas reactivos complejos. Se presenta la metodología realizada en donde se realiza una extensión de los diagramas de transición – estado para los cuales las nociones de jerarquía y ortogonalidad han sido introducidas. Recientemente, Statecharts han sido sugeridos para representar modelos de desempeño. En esos modelos de desempeño, el comportamiento de un sistema bajo estudios se considera probabilístico y con este interés se han desarrollado software dedicados a esta tarea. Por consiguiente, la inclusión de probabilidades en protocolo Statecharts es el interes de este artículo. Dado que un sistema reactivo es modelado probabilísticamente para eventos. Este modelo en Statecharts es equivalente una cadena o proceso de Markov en tiempo continuo, por tanto se construye un modelo analítico del modelo y se presenta el aspecto de generación de una cadena de Markov de una representación Statecharts junto con la solución para incluir probabilidades entre las transiciones. En este artículo presentamos los Statecharts a partir de la utilización del Toolbox de Matlab llamado Statefl ow.
Certificación de productos joyería y buenas prácticas de manufactura en la localidad de La Candelaria
Authors: Lombana Sosa Rafael Humberto , Díaz Mejia Humberto 
Published: August 2018

Los resultados obtenidos en los proyectos de investigación de la línea de Gestión de Tecnología demuestran que los empresarios son conscientes de tener muchos vacíos, reconocen la ausencia de normas y patrones de producción, no hay exigencias de calidad en las aleaciones de metales preciosos, existen grados de merma signifi cativos en el armado y los terminados son defi cientes.Existe una necesidad sentida de involucrar en toda la cadena logística del sector joyero lo que compete con normalización y certifi cación de materias primas, procesos y productos terminados, adicionalmente hacer los estudios necesarios que tienen que ver con la creación de un organismo en la localidad de la Candelaria de certifi cación de calidad, para estandarizar tanto los preprocesos, como los procesos y legitimar con la marca La Candelaria a los productos o servicios que cumplan los requisitos establecidos por el mercado, labor que debe ser desarrollada en conjunto por los empresarios, la Universidad y los estamentos del estado indicados y pertinentes, para tal fin.Para mejorar su posicionamiento en todos los aspectos a los empresarios del sector joyero de la localidad de la Candelaria, se recomienda por parte de los investigadores de la línea de Gestión de Tecnología el diseño de procedimientos de certifi cación y manual de Buenas Prácticas de Manufactura de la joyería en la Localidad de la Candelaria y su posterior replica en otras localidades de Bogotá y Colombia no sin antes establecer una capacitación que tiene que ver con la cultura de normalización, certifi cación, confi anza y ética.
Aplikasi pembayaran administrasi santri terintegrasi SMS gateway
Authors: Wahyudi Rizki , Rhinaldi Krisna 
Published: August 2018

Penelitian ini bertujuan untuk membuat aplikasi pengolahan data administrasi santri yang terintegrasi SMS gateway. Pengolahan data dalam proses pembayaran administrasi santri masih dilakukan secara konvensional. Hal ini menyebabkan beberapa permasalahan, diantaranya adalah terjadi redundansi data yang terdapat pada laporan pembayaran, kesulitan mencari arsip pembayaran yang sudah dilakukan santri. Agar aplikasi dapat dikembangkan dan terukur, maka digunakan metode pengembangan sistem Waterfall. Pengujian dilakukan dengan dua pendekatan alpha testing dan beta testing. Alpha testing merupakan pengujian yang dilakukan di sisi pengembang untuk menguji fungsional sistem menggunakan metode Black box, hasil pengujian alpha testing memperlihatkan bahwa semua fungsional sistem berfungsi dengan baik, dan beta testing dilakukan menggunakan metode kuesioner untuk menguji sistem pada pengguna akhir berkaitan dengan kelayakan aplikasi. Hasil pengujian beta testing didapat prosentasi 95,5% pengguna setuju sistem telah layak di implementasikan. This research aims to build an application to proceed administrative data of santri whis is integrated with SMS gateway service, This study aims to make the application of administrative data processing santri integrated SMS gateway, Data processing in the payment process of the santri administration is still done conventionally. It caused some problems such as redundancy of data contained in the payment report, the difficulty of looking for payment archives that have been done santri, can be developed with measurable, then used Waterfall model system development method with the stages of analysis, design, coding, testing. Testing is done with two approaches of Alpha Testing and Beta Testing. Alpha Testing is a test done on the developer side to test the functional system using Black Box method, Alpha Testing result of all functional system works properly, and Beta Testing is done using questionnaire method to test the system on the end user related to application feasibility, 95.5% of users agree the system is feasible to implement.