bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Structure Modeling and Assembly Practice of Ditching Fertilizer Based on Standardized Module Design
Authors: Zhang Yuan , Deng Yiguo , Wang Yeqin , Chen Peimin , Yan Bo , Zou Xiangjun , Zheng Yong , Wu Sihao , Zhu Huixian 
Published: August 2019

Abstract
In the existing agricultural machinery field, the agricultural machinery is generally cumbersome, the transportation, disassembly and assembly, maintenance procedures are more complicated, and the functions are single, and the versatility is not good. This article combines the industrial design standardization and modularization ideas for the trenching fertilizer application machine. Model construction and assembly practice were carried out. The whole machine was built according to independent functions, and divided into racks, fertilisers, trenching assemblies, suspension systems, transmission systems, etc. Modeling of the rack, modeling of the fertilizer turntable, and plowing the modeling process is elaborated. By assembling the functional components and standard parts, the modular design idea can be reused and exchanged in the design of the trenching fertilizer machine. The relevant modules can form the final product through the arrangement and combination. The final assembly entity can be a variety of products, which can better meet the customer’s customization needs; the repetitive use of similarity can make the whole product more convenient in manufacturing and maintenance, and the overall machine coordination and appearance are more beautiful.
Extraction and Analysis of Rock Painting Color Data Based on Data Association of Color Psychology
Authors: Shang guannan 
Published: August 2019

Abstract
We should continue to dig and develop the breakthrough point of color composition in rock color painting based on color psychology. This paper objectively evaluates the present situation of rock color painting in contemporary China. We should conform to the development of contemporary multiculturalism. We should promote and inherit the development of rock paintings, so as to broaden the manifestations of rock paintings and truly meet the aesthetic demands and value pursuits of contemporary people in the new context.
Methods and resources to access mutation-dependent effects on cancer drug treatment
Authors: Yao Hongcheng , Liang Qian , Qian Xinyi , Wang Junwen , Sham Pak Chung , Li Mulin Jun 
Published: August 2019

Abstract
In clinical cancer treatment, genomic alterations would often affect the response of patients to anticancer drugs. Studies have shown that molecular features of tumors could be biomarkers predictive of sensitivity or resistance to anticancer agents, but the identification of actionable mutations are often constrained by the incomplete understanding of cancer genomes. Recent progresses of next-generation sequencing technology greatly facilitate the extensive molecular characterization of tumors and promote precision medicine in cancers. More and more clinical studies, cancer cell lines studies, CRISPR screening studies as well as patient-derived model studies were performed to identify potential actionable mutations predictive of drug response, which provide rich resources of molecularly and pharmacologically profiled cancer samples at different levels. Such abundance of data also enables the development of various computational models and algorithms to solve the problem of drug sensitivity prediction, biomarker identification and in silico drug prioritization by the integration of multiomics data. Here, we review the recent development of methods and resources that identifies mutation-dependent effects for cancer treatment in clinical studies, functional genomics studies and computational studies and discuss the remaining gaps and future directions in this area.
Ascorbic acid and CoQ10 ameliorate the reproductive ability of superoxide dismutase 1-deficient female mice†
Authors: Ishii Naoki , Homma Takujiro , Lee Jaeyong , Mitsuhashi Hikaru , Yamada Ken-ichi , Kimura Naoko , Yamamoto Yorihiro , Fujii and Junichi 
Published: August 2019

Abstract
Superoxide dismutase 1 suppresses oxidative stress within cells by decreasing the levels of superoxide anions. A dysfunction of the ovary and/or an aberrant production of sex hormones are suspected causes for infertility in superoxide dismutase 1-knockout mice. We report on attempts to rescue the infertility in female knockout mice by providing two antioxidants, ascorbic acid and/or coenzyme Q10, as supplements in the drinking water of the knockout mice after weaning and on an investigation of their reproductive ability. On the first parturition, 80% of the untreated knockout mice produced smaller litter sizes compared with wild-type mice (average 2.8 vs 7.3 pups/mouse), and supplementing with these antioxidants failed to improve these litter sizes. However, in the second parturition of the knockout mice, the parturition rate was increased from 18% to 44–75% as the result of the administration of antioxidants. While plasma levels of progesterone at 7.5 days of pregnancy were essentially the same between the wild-type and knockout mice and were not changed by the supplementation of these antioxidants, sizes of corpus luteum cells, which were smaller in the knockout mouse ovaries after the first parturition, were significantly ameliorated in the knockout mouse with the administration of the antioxidants. Moreover, the impaired vasculogenesis in uterus/placenta was also improved by ascorbic acid supplementation. We thus conclude that ascorbic acid and/or coenzyme Q10 are involved in maintaining ovarian and uterus/placenta homeostasis against insults that are augmented during pregnancy and that their use might have positive effects in terms of improving female fertility.
Successful Invasions of Short Internally Deleted Elements (SIDEs) and Its Partner CR1 in Lepidoptera Insects
Authors: Wang Ping-Lan , Luchetti Andrea , Alberto Ruggieri Angelo , Xiong Xiao-Min , Xu Min-Rui-Xuan , Zhang Xiao-Gu , Zhang Hua-Hao 
Published: August 2019

AbstractAlthough DNA transposons often generated internal deleted derivatives such as miniature inverted-repeat transposable elements, short internally deleted elements (SIDEs) derived from nonlong terminal-repeat retrotransposons are rare. Here, we found a novel SIDE, named Persaeus, that originated from the chicken repeat 1 (CR1) retrotransposon Zenon and it has been found widespread in Lepidoptera insects. Our findings suggested that Persaeus and the partner Zenon have experienced a transposition burst in their host genomes and the copy number of Persaeus and Zenon in assayed genomes are significantly correlated. Accordingly, the activity though age analysis indicated that the replication wave of Persaeus coincided with that of Zenon. Phylogenetic analyses suggested that Persaeus may have evolved at least four times independently, and that it has been vertically transferred into its host genomes. Together, our results provide new insights into the evolution dynamics of SIDEs and its partner non-LTRs.
Criteria for Algebraicity of Analytic Functions
Authors: Bochnak Jacek , Gwoździewicz Janusz , Kucharz Wojciech 
Published: August 2019

Abstract
We consider functions defined on an open subset of a nonsingular, either real or complex, algebraic set. We give criteria for an analytic function to be a Nash (resp. regular, resp. polynomial) function. Our criteria depend only on the behavior of such a function along irreducible nonsingular algebraic curves passing through a given point. In the proofs we use results on algebraicity of formal power series, which are also established in this paper.
Mental health and self-rated health status of internal migrant workers and the correlated factors analysis in Shanghai, China: a cross-sectional epidemiological study
Authors: Wang Lei , Chen Hao , Ye Bo , Gao Junling , Dai Junming , Wang Fan , Fu Hua 
Published: August 2019

Abstract

Background
A cross-sectional study was conducted in 2018 to investigate the mental health status of internal migrant workers (IMWs) in Shanghai to understand basic information and the mental health status of IMWs.

Methods
The total number of IMWs in the study was 4793 and 4648 questionnaires were valid. We used χ2 test, t test, analysis of variance, linear regression and logistic regression to analyse the data.

Results
Mental health, represented by the nine-item Patient Health Questionnaire score (≥10), was significantly correlated with self-rated income-expenditure status, living with family, job type and alcohol use. The total depression prevalence of IMWs in this study was 20.1%. Subjective well-being (SWB) was significantly correlated with marital status, educational attainment, self-reported income-expenditure status, living with family and job type. Those who were female, had a high school education or above, self-reported inadequate income, did not live with family, had poor self-rated health and had moderate or severe depression were more likely to have lower SWB. Promoting the mental health of IMWs also benefited their physical health.

Conclusions
Chinese migrant workers who were younger, had insufficient self-rated income, had worse self-reported health, used alcohol and were unmarried had a high risk of mental health disorders.
Patient-reported outcome measurements (PROMs) and provider assessment in mental health: a systematic review of the context of implementation
Authors: Roe David , Mazor Yael , Gelkopf Marc 
Published: August 2019

Abstract

Purpose
To review and integrate the vast amount of literature yielded by recent growing interest in patient-reported outcome measurement and routine outcome measures (PROMs/ROMs), in order to suggest options and improvements for implementation. PROMs are the systematic assessment of service users’ health using standardized self-report measures. Specifically, for ROMs, it includes routine provider or caretaker assessment measures. Both are administered to ascertain routinely, the impact of treatment in mental health settings and to improve care. A review is needed because of the large differences in setting, conceptualization, practice and implementation. Here, we examine the different major projects worldwide.

Data sources
Psych INFO and PubMed including Medline, Biomed Central, EMBASE Psychiatry and Elsevier Science’s Direct.

Study selection
We conducted a systematized review of the literature published from 2000 to 2018 on the implementation and sustainability of PROMs and ROMs in mental health services for adults.

Data extraction, synthesis and Results
We described and characterized the programs in different countries worldwide. We identified 103 articles that met the inclusion criteria, representing over 80 PROMs/ROMs initiatives in 15 countries. National policy and structure of mental health services were found to be major factors in implementation. We discuss the great variability in PROMs/ROMs models in different countries, making suggestions for their streamlining and improvement.

Conclusion
We extracted valuable information on the different characteristics of the numerous PROMs/ROMs initiatives worldwide. However, in the absence of a strong nationwide policy effort and support, implementation seems scattered and irregular. Thus, development of the implementation of PROMs/ROMs is left to groups of enthusiastic clinicians and researchers, making sustainability problematic.
Effects of standardized total tract digestible phosphorus on growth performance of 11- to 23-kg pigs fed diets with or without phytase1,2
Authors: Vier Carine M , Dritz Steve S , Wu Fangzhou , Tokach Mike D , DeRouchey Joel M , Goodband Robert D , Gonçalves Márcio A D , Orlando Uislei A D , Woodworth Jason C 
Published: August 2019

Abstract
Two experiments were conducted to determine the standardized total tract digestible phosphorus (STTD P) requirement for 11- to 23-kg nursery pigs fed diets with or without phytase. A total of 1,080 and 2,140 pigs (PIC 359 × Camborough, Hendersonville, TN; initially 11.4 ± 0.29 and 11.1 ± 0.24 kg) were used in Exp. 1 and Exp. 2, respectively. There were 23 to 27 pigs per pen with 6 and 12 replicate pens per treatment in Exp. 1 and Exp. 2, respectively. After weaning, pigs were fed a common pelleted diet with 0.45% STTD P for 7 d, and a common phase 2 meal diet with 0.40% STTD P for 14 d in Exp. 1 and 18 d in Exp. 2. Pens of pigs were then allotted to dietary treatments in a randomized complete block design with body weight (BW) as the blocking factor. In Exp. 1, dietary treatments consisted of 0.26%, 0.30%, 0.33%, 0.38%, 0.43%, 0.48%, and 0.53% STTD P. Treatments were achieved with the inclusion of monocalcium phosphate at the expense of corn. In Exp. 2, diets contained 1,000 phytase units (FYT; Ronozyme Hiphos 2500, DSM Nutritional Products, Inc., Parsippany, NJ) with assumed release value 0.132% STTD P, and treatments consisted of 0.30%, 0.33%, 0.38%, 0.43%, 0.48%, 0.53%, and 0.58% STTD P. These STTD P concentrations included the expected phytase release of 0.132% STTD P. In both experiments, a similar 1.17:1 Ca:P ratio was maintained across treatments. Statistical models included linear model (LM), quadratic polynomial (QP), broken-line linear (BLL), and broken-line quadratic (BLQ). In Exp. 1, increasing STTD P increased (linear, P < 0.001) ADG, ADFI, G:F, final BW, and grams of STTD P intake per day and per kilogram of gain. There was also a marginal quadratic response for G:F (P < 0.066). In Exp. 2, ADG and G:F increased quadratically (P < 0.05), whereas ADFI increased linearly (P = 0.060) with increasing STTD P. The BLL and QP model provided similar fit to G:F in Exp. 1, estimating the requirement for maximum G:F at 0.34% and 0.42%, respectively. The BLL was the best fitting model for ADG and G:F in Exp. 2, estimating the breakpoint at 0.40% and 0.37% STTD P, respectively. The BLL and BLQ models estimated the breakpoint for ADG as a function of STTD P intake in grams per day at 2.92 and 3.02 g/d, respectively. These data provide empirical evidence that for 11- to 23-kg pigs, the NRC (2012) accurately estimates the STTD P requirement on a g/d basis. As a percentage of the diet, the STTD P requirement for diets without or with 1,000 FYT added phytase ranged from 0.34% to 0.42%.
Anti-biofilm activity of a semi-synthetic molecule obtained from resveratrol against Candida albicans biofilm
Authors: Juin Camille , Perrin Flavie , Puy Thomas , Bernard Clément , Mollichella Marie Laure , Girardot Marion , Costa Damien , Guillard Jérôme , Imbert Christine 
Published: August 2019

Abstract
Candida albicans can form biofilm on tissues and medical devices, becoming, in that case, less susceptible to antifungal agents. Treatment of candidiasis associated with the formation of C. albicans biofilms is restricted to echinocandins and lipid forms of amphotericin B. This study investigated the activity of micafungin and resveratrol modified molecule (EB487) against C. albicans biofilms. The anti-biofilm growth (Bgrowth) and anti-preformed biofilm (Bpreformed) activities of micafungin (0 to 3.94 μM) and EB487 (0 to 20.32 mM) were comparatively studied separately and combined, using XTT, flow cytometry and cell counts approaches. Concentrations causing 50% inhibition of the studied steps (IC50) were evaluated. When tested separately, IC50 Bgrowth was obtained for 4.8 mM and 0.13 μM of EB487 and micafungin respectively, and IC50 Bpreformed for 3.6 mM and 0.06 μM of EB487 and micafungin respectively. Micafungin used alone was not able to totally eradicate fungi. Micafungin combined with EB487 displayed synergistic activity (both anti-growth- and anti-preformed biofilm-activities). Optimal combination concentrations were EB487 (≤9.12 mM -strain ATCC 28367™ or ≤8.12 mM -strain CAI4-p), micafungin (≤0.05 μM for both) and caused a total eradication of fungi. Dose reduction indexes obtained using these concentrations were at least 9 (micafungin) and 3.2 (EB487) for both anti-biofilm growth- and anti-preformed biofilm-activities. Combinations indexes were consistently below one, demonstrating a synergistic relationship between micafungin and EB487 in these conditions. This study demonstrated the strong anti-biofilm activity of EB487 and highlighted its synergistic potential when combined with micafungin. EB487 is a promising semi-synthetic molecule with prophylactic and curative interests in fighting C. albicans biofilms.
Hemodynamic Features of Microsurgically Identified, Thin-Walled Regions of Unruptured Middle Cerebral Artery Aneurysms Characterized Using Computational Fluid Dynamics
Authors: Kim Jang Hun , Han Huan , Moon Young-June , Suh Sangil , Kwon Taek-Hyun , Kim Jong Hyun , Chong Kyuha , Yoon Won-Ki 
Published: August 2019

AbstractBACKGROUNDThin-walled regions (TWRs) of aneurysm surfaces observed in microscopic surgery are thought to be vulnerable areas for growth and rupture of unruptured intracranial aneurysms (UIAs).OBJECTIVETo identify hemodynamic features of TWRs of aneurysms by using computational fluid dynamics (CFD) analyses of unruptured middle cerebral artery bifurcation (MCAB) aneurysms.METHODSNine patients with 11 MCAB aneurysms were enrolled, and their TWRs were identified. CFD analysis was performed using 3 parameters: pressure, wall shear stress (WSS), and WSS divergence (WSSD). Each parameter was evaluated for its correspondence with TWR.RESULTSAmong 11 aneurysms, 15 TWRs were identified. Corresponding matches with CFD parameters (pressure, WSS, and WSSD) were 73.33, 46.67, and 86.67%, respectively.CONCLUSIONWSSD, a hemodynamic parameter that accounts for both magnitude and directionality of WSS, showed the highest correspondence. High WSSD might correspond with TWR of intracranial aneurysms, which are likely high-risk areas for rupture.
Sources of knowledge flow between developed and developing nations
Authors: de Rassenfosse Gaétan , Seliger Florian 
Published: August 2019

Abstract
This article provides a long-term view on the sources of knowledge flow between developed and developing nations. It relies on patent data to explore three potential sources: R&D collaboration, technology sourcing, and technology transfer. All three sources provide a very consistent message. First, knowledge flows from East Asia, particularly China, are occurring more frequently. Second, knowledge flows are increasingly concentrated in information and communication technologies. Third, the USA and Canada had traditionally larger patenting activity with Asia than Europe, but the share of activity between Europe and Asia has been increasing in recent years. Larger patenting activity between the USA and Canada and Asia implies that North America is more likely to benefit from the reverse knowledge flows than Europe as China progresses toward becoming a technological leader.
Strategies for Rapid Risk Assessment of Color Additives Used in Medical Devices
Authors: Saylor David M , Chandrasekar Vaishnavi , Simon David D , Turner Paul , Markley Laura C , Hood Alan M 
Published: August 2019

Abstract
Many polymeric medical devices contain color additives for differentiation or labeling. Although some additives can be toxic under certain conditions, the risk associated with the use of these additives in medical device applications is not well established, and evaluating their impact on device biocompatibility can be expensive and time consuming. Therefore, we have developed a framework to conduct screening-level risk assessments to aid in determining whether generating color additive exposure data and further risk evaluation are necessary. We first derive tolerable intake values that are protective for worst-case exposure to 8 commonly used color additives. Next, we establish a model to predict exposure limited only by the diffusive transport of the additive through the polymer matrix. The model is parameterized using a constitutive model for diffusion coefficient (D) as a function of molecular weight (Mw) of the color additive. After segmenting polymer matrices into 4 distinct categories, upper bounds on D(Mw) were determined based on available data for each category. The upper bounds and exposure predictions were validated independently to provide conservative estimates. Because both components (toxicity and exposure) are conservative, a ratio of tolerable intake to exposure in excess of one indicates acceptable risk. Application of this approach to typical colored polymeric materials used in medical devices suggests that additional color additive risk evaluation could be eliminated in a large percentage (≈90%) of scenarios.
Reliability and Validity of the Adapted Dutch Version of the Early-Onset Scoliosis-24-Item Questionnaire (EOSQ-24)
Authors: Wijdicks Sebastiaan P.J. , Dompeling Stephanie D. , de Reuver Steven , Kempen Diederik H.R. , Castelein René M. , Kruyt Moyo C. 
Published: August 2019

Study Design.
Translation and validation of the Early Onset Scoliosis-24 Questionnaire (EOSQ-24).

Objective.
To cross-culturally adapt the English version of the EOSQ-24 to the Dutch language and to assess the questionnaire's reliability and validity.

Summary of Background Data.
Early-onset scoliosis (EOS) has a profound impact on health-related quality of life. The EOSQ-24 is health-related quality of life questionnaire filled in by parents of children with EOS. The EOSQ-24 was already translated into multiple languages and its application was confirmed in clinical studies. However, the EOSQ-24 is not yet translated and validated for the Dutch population.

Methods.
The adaption of the EOSQ-24 for the Dutch population was done in three steps: 1) translation to the Dutch language, 2) cross-cultural adaptation, and 3) cross-cultural validation. To ensure that the Adapted Dutch EOSQ-24 is applicable for clinical use, the measurement properties were tested in four steps: 1) floor and ceiling effects, 2) validation, 3) reliability, and 4) discriminative ability. One hundred three parents completed the Adapted Dutch EOSQ-24, the Child Health Questionnaire (CHQ-28 PF), and the Scoliosis Research Society Questionnaire (SRS-22r). A second EOSQ-24 was completed for test–retest reproducibility.

Results.
The EOSQ-24 was successfully translated, adapted, and validated for the Dutch language. Almost all response items showed a normal distribution. The EOSQ-24 showed excellent reliability (Cronbach α of 0.950). The EOSQ-24 was successfully validated against the CHQ-28-PF and the SRS-22r. Test–retest was excellent (ICC ≥ 0.8). Finally, The EOSQ-24 was found capable to discriminate patients with different curve severities (P = 0.003), diagnosis (P = 0.006), and ambulatory status (P
< 0.001).

Conclusion.
The current Dutch EOSQ-24 proved to be a valid and reliable quality of life assessment tool for patients with EOS. Currently, long follow-up studies using the EOSQ-24, including the Dutch EOSQ-24, are lacking and are needed to fully validate the EOSQ-24 for use in a clinical setting.

Level of Evidence: 2