bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concomitant Repair of Pelvic Floor Disorders in Women Undergoing Surgery for Gynecologic Malignancies
Authors: Bochenska Katarzyna , Mueller Margaret , Geynisman-Tan Julia , Leader-Cramer Alix , Davé Bhumy , Lewicky-Gaupp Christina , Kenton Kimberly 
Published: April 2018

Objective
The aims of this study were to determine the rate and describe 30-day postoperative complications of concomitant pelvic organ prolapse and/or urinary incontinence (POPUI) procedures in women undergoing surgery for a gynecologic malignancy.

Methods
Women who underwent surgical intervention for a gynecologic malignancy between 2010 and 2014 were identified using postoperative International Classification of Diseases, Ninth Revision codes 179.0 to 184.9 in the American College of Surgeons National Surgical Quality Improvement Program database. Women who underwent POPUI procedures were identified using Current Procedural Terminology codes between 51840 and 58294. Infectious, pulmonary, cardiac, and venous thromboembolism complication rates were calculated. Patient demographics and postoperative complication rates were analyzed using Student t, χ2, and Fisher exact tests and compared between women with a gynecologic malignancy who did and did not undergo concomitant POPUI procedures.

Results
We identified 23,501 women with a diagnosis of a gynecologic malignancy. The most common included uterine (63%), ovarian (25%), and cervical cancer (8%). Only a small proportion of the women undergoing gynecologic cancer surgery (n = 556 [2.4%]) had concomitant POPUI procedures. The most commonly performed POPUI procedures included anterior and/or posterior colporrhaphy (n = 205 [32%]), laparoscopic colpopexy (n = 181 [28.2%]), and midurethral sling (n = 70 [10.9%]). There were no differences in 30-day reoperation; infectious, pulmonary, and cardiac complications; or venous thromboembolic events between women who did and did not have concomitant POPUI surgery.

Conclusions
Using a large national surgical database, only 2.4% of women undergoing gynecologic cancer surgery had a concomitant POPUI procedure. Our data suggest that postoperative complications may not increase when concomitant surgery for POPUI is done at the time of gynecologic cancer surgery.
Discrimination of Gram-Positive versus Gram-Negative Bacteria by the Social AmoebaDictyostelium discoideum
Authors: Rashidi Ghazal , Ostrowski Elizabeth A. 
Published: April 2018

AbstractProfessional phagocytes detect, pursue, engulf, and kill bacteria. While all professional phagocytes use chemotaxis to locate bacteria, little is known about whether they can discriminate among them, responding preferentially to some bacteria over others. Here we examine the chemotaxis of the soil amoeba and professional phagocyteDictyostelium discoideumin assays where amoebae were presented with a paired choice of different bacteria. We observed variation in the extent to which they pursue different types of bacteria and preferential migration towards Gram-negative over Gram-positive bacteria. Response profiles were similar for amoebae isolated from different geographic locations, suggesting that chemotaxis preferences are not strongly influenced by any local variation in the bacterial community. Because cyclic adenosine monophosphate (cAMP) is a known chemoattractant forD. discoideum, we tested whether it mediated the preference for Gram-negative bacteria. Chemotaxis was diminished in response to a cAMP-deficient strain ofEscherichia coliand enhanced in response to anE. colistrain that overproduces cAMP. We conclude thatD. discoideumdiscriminates at a distance among bacteria and that discrimination is mediated in part by sensing of cAMP. Preferential sensing and response to different bacteria may help to explain why some amoeba-bacterial associations are more prevalent in nature than others.
bioLQM: a java library for the manipulation and conversion of Logical Qualitative Models of biological networks
Authors: Naldi Aurélien 
Published: April 2018

AbstractHere we introduce bioLQM, a new Java software toolkit for the conversion, modification, and analysis of Logical Qualitative Models of biological regulatory networks, aiming to foster the development of novel complementary tools by providing core modelling operations. Based on the definition of multi-valued logical models, it implements import and export facilities, notably for the recent SBML-qual exchange format, as well as for formats used by several popular tools, facilitating the design of workflows combining these tools. Model modifications enable the definition of various perturbations, as well as model reduction, easing the analysis of large models. Another modification enables the study of multi-valued models with tools limited to the Boolean case. Finally, bioLQM provides a framework for the development of novel analysis tools. The current version implements the usual updating modes for model simulation (notably synchronous, asynchronous, and random asynchronous), as well as some static analysis features for the identification of attractors. The bioLQM software can be integrated into analysis workflows through command line and scripting interfaces. As a Java library, it further provides core data structures to the GINsim and EpiLog interactive tools, which supply graphical interfaces and additional analysis methods for cellular and multi-cellular qualitative models.
Reference-point centering and range-adaptation enhance human reinforcement learning at the cost of irrational preferences
Authors: Bavard Sophie , Lebreton Maël , Khamassi Mehdi , Coricelli Giorgio , Palminteri Stefano 
Published: April 2018

AbstractIn economics and in perceptual decision-making contextual effects are well documented, where decision weights are adjusted as a function of the distribution of stimuli. Yet, in reinforcement learning literature whether and how contextual information pertaining to decision states is integrated in learning algorithms has received comparably little attention. Here, in an attempt to fill this gap, we investigated reinforcement learning behavior and its computational substrates in a task where we orthogonally manipulated both outcome valence and magnitude, resulting in systematic variations in state-values. Over two experiments, model comparison indicated that subjects’ behavior is best accounted for by an algorithm which includes both reference point-dependence and range-adaptation – two crucial features of state-dependent valuation. In addition, we found state-dependent outcome valuation to progressively emerge over time, to be favored by increasing outcome information and to be correlated with explicit understanding of the task structure. Finally, our data clearly show that, while being locally adaptive (for instance in negative valence and small magnitude contexts), state-dependent valuation comes at the cost of seemingly irrational choices, when options are extrapolated out from their original contexts.
Off-target inhibition by active site-targeting SHP2 inhibitors
Authors: Tsutsumi Ryouhei , Ran Hao , Neel Benjamin G. 
Published: April 2018

AbstractDue to the involvement of SHP2 (SH2 domain-containing protein tyrosine phosphatase) in human disease, including Noonan syndrome and cancer, several inhibitors targeting SHP2 have been developed. Here, we report that the commonly used SHP2 inhibitor NSC-78788 does not exhibit robust inhibitory effects on growth factor-dependent MAPK (mitogen-activated protein kinase) pathway activation, and that the recently developed active site-targeting SHP2 inhibitors IIB-08, 11a-1, and GS-493 show off-target effects on ligand-evoked activation/trans-phosphorylation of the PDGFRβ (platelet-derived growth factor receptor β). GS-493 also inhibits purified human PDGFRβ and SRC in vitro, whereas PDGFRβ inhibition by IIB-08 and 11a-1 occurs only in the cellular context. Our results argue for extreme caution in inferring specific functions for SHP2 based on studies using these inhibitors.
Working memory availability affects neural indices of distractor processing during visual search
Authors: Henare Dion T. , Buckley Jude , Corballis Paul M. 
Published: April 2018

AbstractWorking memory and selective attention are traditionally viewed as distinct processes in human cognition. However, increasing research demonstrates significant overlap between these constructs such that as working memory availability decreases, individuals perform worse on attention-based tasks. To date, the neural mechanisms involved in this interaction are unknown. We measured three candidate lateralized event-related potential components (N2pc, Ptc, and SPCN) to observe the effects of increased working memory load on selective processing of targets and distractors. We found that increased working memory load impaired the processing of distractors, but not targets, and this was reflected in attentuation of the Ptc to distractors. We also found that individual performance on the task is related to the neural response to both targets and distractors. This study suggests that working memory availability impacts individuals’ ability to disengage from irrelevant stimuli, and that individual differences in visual search ability under load are related to both target and distractor processing.
Evaluating metabarcoding to analyse diet composition of species foraging in anthropogenic landscapes using Ion Torrent and Illumina sequencing
Authors: Forin-Wiart Marie-Amélie , Poulle Marie-Lazarine , Piry Sylvain , Cosson Jean-François , Larose Claire , Galan Maxime 
Published: April 2018

AbstractDNA metabarcoding of faecal samples is being successfully used to study the foraging niche of species. We assessed the ability of two benchtop high-throughput sequencing (HTS) platforms, to identify a large taxonomic array of food items from domestic cats Felis silvestris catus, including prey and human-related food taxa (pet food and leftovers leaving undetectable solid remains in faeces). Scats from a captive feeding trial (n=41) and from free-ranging individuals (n=326) were collected and analysed using a cytb mini-barcode in independent PCR duplicates on the Ion PGM and the MiSeq platforms. Outputs from MiSeq were more sensitive and reproducible than those from Ion PGM due to a higher sequencing depth and sequence quality on MiSeq. DNA from intact prey taxa was detected more often (82% of the expected occurrences) than DNA from pet food (54%) and raw fish and meat (31%). We assumed that this variability was linked to different degree of DNA degradation: The Ion PGM detected significantly less human-linked food, birds, field voles, murids and shrews in the field-collected samples than the MiSeq platform. Pooling the replicates from both platforms and filtering the data allowed identification of at least one food item in 87.4% of the field-collected samples. Our DNA metabarcoding approach identified 29 prey taxa, of which 25 to species level (90% of items) including 9 rodents, 3 insectivores, 12 birds and 1 reptile and 33 human-related food taxa of which 23 were identified to genus level (75% of items). Our results demonstrate that using HTS platforms such as MiSeq, which provide reads of sufficiently high quantity and quality, with sufficient numbers of technical replicates, is a robust and non-invasive approach for further dietary studies on animals foraging on a wide range of food items in anthropogenic landscapes.
Reliable individual differences in fine-grained cortical functional architecture
Authors: Feilong Ma , Nastase Samuel A. , Guntupalli J. Swaroop , Haxby James V. 
Published: April 2018

AbstractFine-grained functional organization of cortex is not well-conserved across individuals. As a result, individual differences in cortical functional architecture are confounded by topographic idiosyncrasies—i.e., differences in functional-anatomical correspondence. In this study, we used hyperalignment to align information encoded in topographically variable patterns to study individual differences in fine-grained cortical functional architecture in a common representational space. We characterized the structure of individual differences using three common functional indices, and assessed the reliability of this structure across independent samples of data in a natural vision paradigm. Hyperalignment markedly improved the reliability of individual differences across all three indices by resolving topographic idiosyncrasies and accommodating information encoded in spatially fine-grained response patterns. Our results demonstrate that substantial individual differences in cortical functional architecture exist at fine spatial scales, but are inaccessible with anatomical normalization alone.
GlucoPush: A Do-It-Yourself Add-On for Online Tracking of Personal Glucometer Use
Authors: Soenksen Luis R , Mamat Zulkayda 
Published: April 2018

AbstractCurrent public health guidelines on diabetes management recommend frequent self-monitoring and physician tracking of blood glucose to reduce complications caused by this condition. While Internet-of-Things glucometers exist to aid in this goal, most commercial glucometers seen in wide-spread use worldwide do not provide these online tracking capabilities or allow for convenient data sharing with health care providers. This situation is caused, among several factors, due to premium pricing of IoT glucometers and resistance from older users to dispose of their previous glucometers. We propose an add-on strategy to enable IoT integration in glucometers to increase the use of wireless connectivity features in this sector. Here we describe and test a simple do-it-yourself system fabricated with low-cost commercially available wireless connectivity components that aim to demonstrate this IoT augmentation strategy to track glucose readings from previously unconnected standard glucometers.
Probing the origin of matching functional jaws: roles ofDlx5/6in cranial neural crest cells
Authors: Shimizu Miki , Narboux-Nême Nicolas , Gitton Yorick , de Lombares Camille , Fontaine Anastasia , Alfama Gladys , Kitazawa Taro , Kawamura Yumiko , Heude Eglantine , Marshall Lindsey , Higashiyama Hiroki , Wada Youichiro , Kurihara Yukiko , Kurihara Hiroki , Levŕ Giovanni 
Published: April 2018

SUMMARYGnathostome jaws derive from the first pharyngeal arch (PA1), a complex structure constituted by Neural Crest Cells (NCCs), mesodermal, ectodermal and endodermal cells. Here, to determine the regionalized morphogenetic impact ofDlx5/6expression, we specifically target their inactivation or overexpression to NCCs. NCC-specificDlx5/6inactivation (NCCΔDlx5/6) generates severely hypomorphic lower jaws that present typical maxillary traits. Therefore, differently from the symmetric jaws obtained after constitutiveDlx5/6inactivation,NCCΔDlx5/6embryos present a strikingly asymmetric mouth. Reciprocally, forcedDlx5expression in maxillary NCCs provokes the appearance of distinct mandibular characters in the upper jaw. We conclude that: 1)Dlx5/6activation in NCCs invariably determines lower jaw identity; 2) the morphogenetic processes that generate functional matching jaws depend on the harmonization ofDlx5/6expression in NCCs and in distinct ectodermal territories. The co-evolution of synergistic opposing jaws requires the coordination of distinct regulatory pathways involving the same transcription factors in distant embryonic territories.
Dimensions of service quality in higher education – critical review (students’ perspective)
Authors: Gupta Pragya , Kaushik Neeraj 
Published: April 2018

Purpose
The purpose of this paper is to review the dimensions of service quality used in different countries across the world, especially in the higher education sector.

Design/methodology/approach
Content analysis is used to get a comprehensive insight of the studies accumulated from some of the selected databases such as Emerald Insight, Ebsco ABI/inform, etc. All these studies are related to the measuring of service quality in higher education.

Findings
The result of this paper reveals that SERVQUAL is the most widely accepted scale which has its dominance in the higher education setting. The paper focuses on revealing the dimensions which are used in the past studies. The paper notices a huge variation in the items as well as constructs while exploring the dimensions. Further, it is observed that many of the studies considered in this paper picked dimensions from other studies, expert opinions and factor analysis. In addition to this, it is found that different scales are proposed and checked for their reliability and validity through the confirmatory factor analysis. Few studies confirm the validity using average variance extracted (AVE), model fit values and correlations.

Practical implications
The study will help other researchers to get a summarised form of different dimensions used in the higher education setting. It also points out the essential and common dimensions of similar studies. Further, with different samples and geographical location, it can help us to identify how the dimension varies as we move from one part to another around the globe with different samples. Further, it formulates directions to pick correct combination of scale, administration and methods that are useful in collecting the data and getting the inference out of it under correct settings.

Originality/value
The summarisation of different studies will help the researchers to have a holistic view of the important studies that took place in the higher education setting.
Paid internet advertising (PIA) and frequency of apps-buying decisions
Authors: Rezaei Sajad , Emami Maryam , Ismail Nurlida 
Published: April 2018

Purpose
Despite the tremendous advancement of information technology worldwide, a few attempts have been made to uncover the effectiveness of paid internet advertising (PIA) on consumers buying decisions for retail enterprises in emerging markets. The purpose of this paper is to examine the structural relationships between consumer self-confidence, perceived intrusiveness, continuance search intention, attitude towards PIA and frequency of apps-buying decisions.

Design/methodology/approach
A total number of 515 online questionnaires were obtained from a sample of experienced apps shoppers who were disposed to PIA, in order to evaluate the theoretical model. VB-SEM, which is a variance-based structural equation modelling technique, was applied to assess the measurement scales and structural relationship between exogenous and endogenous constructs.

Findings
Overall, the structural results imply that the proposed model explains 0.738 per cent of variances in consumer’s continuance search intention and 0.756 per cent of the frequency of apps-buying decisions. The results support that consumer self-confidence positively influences attitude towards PIA, continuance search intention and frequency of apps-buying decisions; however, consumer self-confidence is negatively related to perceived intrusiveness. Similarly, attitude towards PIA is positively related to continuance search intention and frequency of apps-buying decision. Besides, perceived intrusiveness negatively influences attitude towards PIA, continuance search intention and frequency of apps-buying decisions. Finally, continuance search intention and the frequency of apps-buying decisions are positively related.

Originality/value
Despite the fact that PIA and its utilisation has been a recent growing trend in managing retail enterprises worldwide, a few studies have been conducted on possible end results of PIA, including consumer continuous apps search intention and purchase decisions.
Intellectual capital efficiency and corporate book value: evidence from Nigerian economy
Authors: Anifowose Mutalib , Abdul Rashid Hafiz Majdi , Annuar Hairul Azlan , Ibrahim Hassan 
Published: April 2018

Purpose
The purpose of this paper is to examine the value relevance of intellectual capital (IC) by analysing the relationship between IC efficiency (ICE) and corporate book value of listed firms on main board of Nigeria Stock Exchange.

Design/methodology/approach
This study applies the resource-based theory in formulating two hypotheses that guide the results analysis. By employing a two-step dynamic system generalised method of moments (GMMs), and controlling for the possible endogeneity effect on the parameters estimated, for a sample of 91 listed firms on main board of Nigeria Stock Exchange, this study investigates the association of ICE and corporate book value, namely, cash flow from operation and economic value added (EVA), using data over the 2010 to 2014 financial years.

Findings
The results show a significant positive relationship between overall ICE and corporate book value (cash flow from operation and EVA). This study contributes to recent evidence concerning the value relevance of IC information to investors and other interested stakeholders.

Research limitations/implications
The generalisation of the results to smaller firms, in the alternative securities market, may be inappropriate as study sampled listed firms on the main board of Nigerian Stock Exchange.

Practical implications
Those charged with governance should be concerned with the investment and management of IC as it enhances the economic value and operating cash flow in line with the resource-based theory.

Originality/value
This study is first to consider the ICE study across all sectors in the Nigerian economy using modified Pulic value added intellectual capital. The study controls for heteroscedasticity and endogeneity issues by adoption of two-step dynamic system GMMs.
How to be an Exchequer Clerk in the Twelfth Century: What the Dialogue of the Exchequer is Really About
Authors: KYPTA ULLA 
Published: April 2018

AbstractThe article contributes to the ongoing discussion about the Dialogue of the Exchequer. For quite a long time researchers have been puzzled by the treatise written by the royal treasurer Richard of Ely around the year 1180. It has been regarded as a manual for Exchequer clerks, describing in great detail the workings of Henry II's financial administration. Several of these details, however, have been proven to be wrong or not relevant for the clerks’ work. By comparing the Dialogue with the actual records written during the accounting procedures of the twelfth century – the pipe rolls – and by analysing the Dialogue, I come to the conclusion that the Dialogue did not serve as a guidebook on how to write a pipe roll, but as a guidebook on how to be, and how to think, as an Exchequer clerk.
British Emigrants and the Making of the Anglosphere
Authors: RICHARDS ERIC 
Published: April 2018

AbstractBritish emigrants tend to be lost in their vast numbers and in their historiographical anonymity. They feature very marginally in most interpretations of British expansion in the age of imperialism. There was a remarkable surge in emigration in the 1820s which presaged the Age of Emigration in the Victorian era. This was also a prototype of modern international migration. The origins of this momentous increase in emigration are unclear but recent emphasis gives priority to the influence of the new forms of propaganda and ‘puffery’. In this article it is contended that more consideration should be accorded to bedrock changes in British demography and agrarian life in the propulsion of this mass emigration, which eventually involved about 19 million people from the British Isles in the long nineteenth century.