bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crust-cooling Models Are Insensitive to the Crust–Core Transition Pressure for Realistic Equations of State
Authors: Lalit Sudhanva , Meisel Zach , Brown Edward F. 
Published: September 2019

Abstract
Neutron stars cooling after sustained accretion outbursts provide unique information about the neutron star crust and underlying dense matter. Comparisons between astronomical observations of these cooling transients and model calculations of neutron star crust cooling have frequently been used to constrain neutron star properties such as the mass, radius, crust composition, and presence of nuclear pasta. These calculations often use a fixed pressure at which the crust–core transition happens, though this quantity depends on the dense matter equation of state. We demonstrate that varying the crust–core transition pressure in a manner consistent with adopting various equations of state results in modest changes to the crust-cooling light curve. This validates the approach adopted in most crust-cooling studies to date, where the neutron star mass and radius are varied while leaving the crust–core transition pressure constant.
Stealth Coronal Mass Ejections from Active Regions
Authors: O’Kane Jennifer , Green Lucie , Long David M. , Reid Hamish 
Published: September 2019

Abstract
Stealth coronal mass ejections (CMEs) are eruptions from the Sun that have no obvious low coronal signature. These CMEs are characteristically slower events but can still be geoeffective and affect space weather at Earth. Therefore, understanding the science underpinning these eruptions will greatly improve our ability to detect and, eventually, forecast them. We present a study of two stealth CMEs analyzed using advanced image processing techniques that reveal their faint signatures in observations from the extreme-ultraviolet (EUV) imagers on board the Solar and Heliospheric Observatory, Solar Dynamics Observatory, and Solar Terrestrial Relations Observatory spacecraft. The different viewpoints given by these spacecraft provide the opportunity to study each eruption from above and the side contemporaneously. For each event, EUV and magnetogram observations were combined to reveal the coronal structure that erupted. For one event, the observations indicate the presence of a magnetic flux rope before the CME’s fast-rise phase. We found that both events originated in active regions and are likely to be sympathetic CMEs triggered by a nearby eruption. We discuss the physical processes that occurred in the time leading up to the onset of each stealth CME and conclude that these eruptions are part of the low-energy and velocity tail of a distribution of CME events and are not a distinct phenomenon.
Decision Making in Selecting Mobile Payment Systems
Authors: Chaiyasoonthorn Wornchanok 
Published: September 2019

Thailand is transforming its economy into a digital economy. Mobile payment (m-payment) is a core technology that helps the country phases from the manu-facturing-based economy into the digital economy. However, a question remains what factors influencing people to adopt mobile payment. Little literature focuses on users in Thailand. This study aims to determine factors associating with the decision-making process in selecting m-payment systems of respondents in Bangkok. The study addresses a research question. What do factors segregate m-payment adoption? 820 respondents were asked by using a questionnaire. Em-ployment of confirmatory factor analysis (CFA) developed the measurement showing acceptable validity and reliability. The study uses multinomial logistic regression to classify Technology Choices (TCs). The results show low values of Pseudo R-Square, indicating that there is a lack of practical variables. Discus-sions and suggestions are addressed in this research.
Spirituality and Social Media: Connecting the Dots
Authors: Rautela Sonica , Sharma Adya 
Published: September 2019

Spirituality has gained the interest of all generations in the past few years. The concept of spirituality is very old but its popularity in the last few decades is worth noticing. Today spirituality is making inroads in different sectors like health sector, education, working culture etc. Social media on the other hand is a relatively new phenomenon which has changed the world forever. The impact and reach of social media is the maximum among all media tools. With the increased use of smart phone and other interactive technologies social media usage has grown with huge leaps and bounds. The paper tries to find a link to connect the old with new in search of a principled life as advocated by spirituality. The paper explores the journey of Spirituality and its usefulness in current context. The paper then traces the rise and impact of social media. The paper concludes by proposing a conceptual model that depicts use of social media to educate about spirituality. The integrative approach identifies the positive aspects of social media to reach out to people.
Matériaux d’écrivains : conversation avec Raharimanana et Sami Tchak
Authors: Raharimanana  , Tchak Sami 
Published: September 2019

Raharimanana : « J’aimerais orienter mes interventions autour de la complexité de porter les images dans un contexte d’écriture malgache :* une écriture qui prend ses sources dans la tradition antakarana (voir dans mon roman Revenir) ;* une écriture qui interroge les images en contexte dominé (colonisation, dictature, voir Madagascar, 1947, Portraits d’insurgés avec Pierrot Men, et Les Cauchemars du gecko et Des ruines)* une écriture personnelle, de l’artiste que je suis, interroger l’image, Les Cauchemars du gecko, Des ruines. Chacune de mes séquences commencerait avec une lecture musicale et projection des images en question. »Sami Tchak : « Je pourrais intituler ma communication « L’abeille et la mouche ». Ce sera pour revenir à mon idée exprimée dans Filles de Mexico, puis dans Ainsi parlait mon père, et qui traduit ma conception du terrain : Tout créateur est à la fois une mouche et une abeille. En tant qu’abeille, il va aux fleurs, et en tant que mouche, il va à la merde. À lui ensuite, à force de travail, avec persévérance, telles les mouches et les abeilles, de se hisser, à partir de ces matériaux, à la hauteur de l’universelle condition des vivants, de tous les vivants. »
Soluble epoxide hydrolase (Ephx2) silencing attenuates the hydrogen peroxide-induced oxidative damage in IEC-6 cells
Authors: Li Xiaohua , Wu Xiaoqin 
Published: September 2019

IntroductionOxidative stress can cause intestinal disease. Soluble epoxide hydrolase (sEH, Ephx2) is related to cell apoptosis. The effect of Ephx2 on the H2O2-induced oxidative damage remains unclear. Thus, we aimed to explore the effect of Ephx2 on oxidative damage and the underlying potential mechanism.Material and methodsThe cell viability was determined using cell counting kit-8 (CCK-8) assay. The reactive oxygen species (ROS), apoptosis, and mitochondrial membrane potential (MMP) were examined using flow cyto­metry analysis. Commercial kits were applied to respectively determine the lactate dehydrogenase (LDH) leakage, malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity. The expressions of target factors were measured by conducting quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blot.ResultsWe found that knockdown of Ephx2 enhanced the viability of H2O2-treated IEC-6 cells, and that si-Ephx2 reduced the ROS level, MMP loss, and apoptosis in comparison to the H2O2 model group. Knockdown of Ephx2 was found to decrease LDH activity and MDA content, and to improve the SOD activity in comparison to those in the H2O2 model group. Knockdown of Ephx2 reduced the expressions of Fas, Fasl, Bax, and cleavedcaspase-3 and elevated the expression of Bcl-2 in H2O2-treated IEC-6 cells. Furthermore, we observed that knockdown of Ephx2 enhanced the phosphorylation of PI3K, Akt, and GSK3, which were reduced by the treatment of H2O2. In addition, the anti-apoptotic effect of si-Ephx2 was enhanced in the presence of AUDA-pharmacological Ephx2 inhibitor.ConclusionsEphx2 silencing inhibited H2O2-induced oxidative damage. The PI3K/Akt/GSK3 pathway was related to the effect of si-Ephx2. Our study provided a potential target for the prevention of intestinal injury.
miR-23b-3p regulates differentiation of osteoclasts
by targeting PTEN via the PI3k/AKT pathway
Authors: Chai Jiwei , Xu Liang , Liu Niansheng 
Published: September 2019

IntroductionOsteoblasts and osteoclasts are cells of osteoblastic origin, and are vital in homeostasis of the skeleton. miRs are important for functioning, survival and differentiation of osteoclasts. It has been reported previously that miR-23b-3p is involved in osteoporosis and in regulation of differentiation of osteoblasts. It is also involved in the process of bone formation. However, the role of miR-23b-3p in differentiation of osteoclasts remains unexplored.Material and methodsCSF-1 and ODF induced osteoclasts were used for the study. RNA isolation was done from TIB-71 cells. TRAP staining was done for TRAP-positive osteoclast formation. PIT assay for bone resorption was performed. For in vivo studies osteoclast-specific miR-23b-3p transgenic mice were developed.ResultsThe levels of miR-23b-3p were upregulated in bone marrow monocytes during osteoclastogenesis with colony stimulating factor-1 and osteoclast differentiation factor induction, which suggests that miR-23b-3p plays a crucial role in differentiation of osteoclasts. Over-expression of miR-23b-3p in bone marrow monocytes leads to osteoclastogenesis, whereas the inhibition ameliorates it. We further studied the function of miR-23b-3p via PI3K/AKT targeting the PTEN pathway. In vivo, osteoclast-specific miR-23b-3p transgenic mice showed suppressed PTEN and elevated osteoclast activity, and the mice showed decreased bone mineral density.ConclusionsThe results suggest that miR-23b-3p regulates the differentiation of osteoclasts by targeting PTEN through the PI3K/AKT cascade.
Evaluation of protective effects of GnRH agonist or antagonist on ovarian reserve with anti-Müllerian hormone and histological analysis in a rat model using cisplatin
Authors: Tas Mustafa , Oner Gokalp , Ulug Pasa , Yavuz Adem , Ozcelik Bulent 
Published: September 2019

IntroductionThe aim of this prospective trial was to evaluate the ovarian reserve with anti-Müllerian hormone (AMH), which is the best predictor of ovarian reserve, and perform histological analysis after exposure to cisplatin with a GnRH agonist or antagonist.Material and methodsTwenty-four Wistar albino rats were randomly divided into three groups, each consisting of eight rats. In the GnRH agonist group (group 1), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg triptorelin. In the GnRH antagonist group (group 2), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg cetrorelix. In the control group (group 3), rats received 50 mg/m2 cisplatin. Ovarian reserve was assessed by AMH and histology.ResultsPrimary follicle counts were higher in group 2 (4.50 ±1.47 vs. 3.50 ±1.70 vs. 3.00 ±3.54) and secondary follicle counts were higher in group 1 (2.96 ±1.11 vs. 1.74 ±1.03 vs. 1.37 ±3.11). Numbers of tertiary follicles were higher both in groups 1 and 2 than the control group (1.36 ±0.83 vs. 0.84 ±0.99 vs. 0.50 ±0.75). The total follicle count of the study groups were significantly higher compared with the control group (14.32 ±5.96 vs. 12.48 ±4.12 vs. 10.63 ±6.80). AMH was significantly higher in groups 1 and 2 compared with the control group (18.56 ±25.33 vs. 16.48 ±24.66 vs. 9.37 ±26.54).ConclusionsThis is the first prospective randomized controlled study showing the protective effects of GnRH agonist and antagonist on ovarian reserve after cisplatin exposure in an animal model.
Tofacitinib in the treatment of active rheumatoid arthritis – single-centre experience
Authors: Madej Marta , Woytala Patryk , Frankowski Marek , Lubiński Łukasz , Sokolik Renata , Sebastian Agata , Maciążek-Chyra Beata , Wiland Piotr 
Published: September 2019

ObjectivesTo assess the efficacy and safety profile of tofacitinib taken orally at a dose of 10 mg/day in patients with severe active rheumatoid arthritis (RA).Material and methodsThe retrospective observational study included 10 patients (6 women and 4 men) with RA treated with tofacitinib. All the patients had high disease activity (DAS28 [ESR] > 5.1), despite therapy with two synthetic disease-modifying antirheumatic drugs (DMARDs). Before the initiation of treatment, routine laboratory tests were performed, and disease activity was assessed in all the subjects.ResultsThe mean age of the patients in the study group was 58.18 years (43–67). The average duration of RA was 9.9 years (2–24). The mean baseline value of DAS28 (ESR) was 6.37. Tofacitinib was used in combination with a conventional DMARD in all study subjects: with methotrexate in the majority of patients, and with leflunomide and an antimalarial drug in three patients. The mean duration of therapy with tofacitinib was 7.57 months (3.9–10.8). A significant decrease in the disease activity was observed (p < 0.05). A reduction in DAS28 (ESR) score was seen already after the first month of therapy, and the trend was maintained during subsequent months of follow-up. The mean value of DAS28 (ESR) after 6 months was 2.78. A slight increase in the serum concentration of HDL cholesterol was observed during treatment. In one patient symptoms of chronic upper respiratory tract infection led to discontinuation of the drug. The observed adverse events were of mild/moderate degree.ConclusionsThe results of our retrospective observational study conducted in the setting of daily clinical practice confirm a good clinical response to tofacitinib. Despite the observed adverse effects, in the light of the available data tofacitinib demonstrates a favourable safety profile. JAK kinase inhibitors – a new class of drugs – will enable a wider population of patients to achieve remission or low disease activity.
The use of surface electromyography in rehabilitating rheumatic patients after knee arthroplasty (pilot study)
Authors: Prusinowska Agnieszka , Komorowski Arkadiusz , Syrówka Piotr 
Published: September 2019

ObjectivesThe aim of the conducted research was to assess muscle performance in rheumatic patients qualified for knee arthroplasty before and after surgical treatment.Material and methodsPatients with the diagnosis of rheumatoid arthritis or a degenerative joint disease qualified for surgical treatment were examined. Three groups were analysed: 1) a control group, 2) a group of patients qualified for knee arthroplasty (G1), 3) a group of patients with one knee joint endoprosthesis qualified for the second surgery (G2). The study was carried out through a portable surface electromyography system from Noraxon U.S.A. INC., Clinical DTS and using surface electrodes. The surface electromyography (sEMG) examination was conducted twice: before and on the 10th day after the surgery. The study concerned the quadriceps femoris muscle, i.e. its straight and medial head in both lower limbs during isometric tension and active movement.ResultsThe comparison of the examined muscles’ activity in the control group revealed greatly increased activity during isometric tension than during active movement in both muscles. In the G1 group, the comparison of the average values of isometric tension of the examined muscles before the surgery showed slight differences between the healthy limb and the one qualified for the surgical treatment. After the surgery, significant asymmetry between the average values achieved by the healthy and the operated limb could be identified in both muscles. In the G2 group, muscle activity within the currently operated limb revealed only slight differences between the limbs before the surgery. After the surgery, there was an increase in muscle activity within the previously operated limb.ConclusionsConsiderably higher average values of muscle activity during the isometric tension, when compared to the active movement in a sitting position, indicate the necessity of more widespread use of isometric tension in rehabilitating patients after knee arthroplasty.
Tossing and turning with degenerative arthropathy: an assessment of poor sleep quality in knee osteoarthritis
Authors: Akintayo Richard Oluyinka , Yerima Abubakar , Uhunmwangho Courage , Olaosebikan Hakeem , Akpabio Akpabio Akanimo 
Published: September 2019

ObjectivesTo determine the frequency and predictors of sleep abnormalities among patients with knee osteoarthritis (OA) in Nigeria.Material and methodsA multi-centre, hospital-based, cross-sectional study, involving 250 knee OA patients. Consenting patients 18 years and above, who satisfied the American College of Rheumatology (ACR) criteria for knee OA were recruited from five Nigerian tertiary centres over 3 months. An interviewer-administered questionnaire was used to collect demographic and relevant clinical information. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality with scores ≥ 5 indicating poor sleep. Other variables assessed were pain, depression, functional class and family functioning. Data were summarized using appropriate measures of central tendency and dispersion. Multiple logistic regression analysis was done to identify predictors of poor sleep. Analysis was done using SPSS version 21.0 with p < 0.05 considered significant. Study approval was obtained from the ethical committees of each of the study sites.ResultsParticipants included 209 females (83.6%) with mean age 59.9 ±10.6 years. One hundred and forty-one participants (56.4%) had PSQI scores ≥ 5 (poor sleep). This was significantly associated with depression (p < 0.001), level of education (p = 0.001), higher pain scores (p < 0.001), body mass index (p = 0.040), medial knee OA (p = 0.032) and patello-femoral OA (p = 0.002). Higher level of education, worse depression scores and higher WOMAC pain scores were the best predictors of poor sleep quality.ConclusionSleep quality was poor in over half of our knee OA patients and best predicted by depression, pain and level of education. Regular sleep quality assessment for knee OA patients is recommended.
Characterizing photosymbiosis in modern planktonic foraminifera
Authors: Takagi Haruka , Kimoto Katsunori , Fujiki Tetsuichi , Saito Hiroaki , Schmidt Christiane , Kucera Michal , Moriya Kazuyoshi 
Published: September 2019

Abstract. Photosymbiosis has played a key role in the
diversification of foraminifera and their carbonate production throughout
geologic history. However, identification of photosymbiosis in extinct taxa
remains challenging, and even among the extant species the occurrence and
functional relevance of photosymbiosis remain poorly constrained. Here, we
investigate photosymbiosis in living planktonic foraminifera by measuring
active chlorophyll fluorescence with fast repetition rate fluorometry. This
method provides unequivocal evidence for the presence of photosynthetic
capacity in individual foraminifera, and it allows us to characterize
multiple features of symbiont photosynthesis including chlorophyll a (Chl a) content, potential photosynthetic activity (Fv∕Fm), and light-absorption efficiency (σPSII). To obtain robust evidence for
the occurrence and importance of photosymbiosis in modern planktonic
foraminifera, we conducted measurements on 1266 individuals from 30 species
of the families Globigerinidae, Hastigerinidae, Globorotaliidae, and
Candeinidae. Among the studied species, 19 were recognized as symbiotic and
11 as non-symbiotic. Of these, six species were newly confirmed as symbiotic
and five as non-symbiotic. Photosymbiotic species have been identified in
all families except the Hastigerinidae. A significant positive correlation
between test size and Chl a content, found in 16 species, is interpreted as
symbiont abundance scaled to the growth of the host and is consistent with
persistent possession of symbionts through the lifetime of the foraminifera.
The remaining three symbiont-bearing species did not show such a
relationship, and their Fv∕Fm values were comparatively low,
indicating that their symbionts do not grow once acquired from the
environment. The objectively quantified photosymbiotic characteristics have
been used to design a metric of photosymbiosis, which allows the studied
species to be classified along a gradient of photosynthetic activity,
providing a framework for future ecological and physiological investigations
of planktonic foraminifera.
Produção agrícola no estado do Mato Grosso e a relação entre o agronegócio e as cidades: o caso de Lucas do Rio Verde e Sorriso
Authors: Von Dentz Eduardo 
Published: September 2019

Nas últimas duas décadas, principalmente, a produção agrícola do estado do Mato Grosso teve uma grande evolução, tendo transformado o estado no maior produtor nacional de grãos, com destaque para as culturas de soja, milho, algodão e girassol. Ao passo que a produção agrícola cresceu, foi se percebendo uma estreita relação entre o agronegócio e as cidades. Por essas questões, o objetivo desse artigo é demonstrar a dinâmica recente da produção agrícola do estado do Mato Grosso e a relação do agronegócio com as cidades. Metodologicamente o artigo foi construído através da revisão bibliográfica, levantamento de dados e trabalhos de campo. Como resultados principais, pode-se dizer que o potencial agrícola do Mato Grosso cresceu muito em função dos incentivos das políticas de Estado e do favorecimento das condições edafoclimáticas que as terras do Mato Grosso oferecem. Na relação entre o agronegócio e as cidades, é possível afirmar que a antiga sobreposição ou submissão de um em relação ao outro não pode ser aplicada a este cenário, haja vista que identificamos uma relação de complementariedade entre o agronegócio e as cidades.
Palavras chave: Produção agrícola; Agronegócio; Cidade; Mato Grosso.
Do anime para o jogo: espaços evocativos de Os Cavaleiros do Zodíaco
Authors: Drummond Washington 
Published: September 2019

Este artigo teve como objetivo analisar os espaços evocativos dos jogos Cavaleiros do Zodíaco: Alma dos Soldados e Os Cavaleiros do Zodíaco: Batalha do Santuário, e compreender o papel que a paisagem exerce em ambos. Como método realizou-se revisão bibliográfica dos estudos sobre os videogames, com destaque àqueles concernentes ao escopo da Geografia, assim como o contato mais íntimo com os espaços do anime, reassistindo as temporadas, e com os espaços evocativos dos jogos, jogando-os e observando considerações de outros jogadores. Verificou-se que os espaços evocativos dos jogos amplificam o senso de imersão dos jogadores no mundo ficcional de Os Cavaleiros do Zodíaco, assim como comunicam novas perspectivas da história e da espacialidade desse universo.
Palavras-chave: Representação. Videogames. Espaço do jogo. Espaços evocativos.
Sense Experience and Poly-intentionality in Merleau-Ponty's Phenomenology of Perception
Authors: Montani John 
Published: September 2019

ABSTRACT
This essay argues for a conception of poly-intentionality based on Merleau-Ponty's analysis of sense experience in his Phenomenology of Perception. I start by reviewing the tenuous status of sensation in Husserl's early work in order to prepare for a renewed conception of intentionality inspired by Merleau-Ponty—one that is grounded in the body's sense organs. I show how sensations accomplish a form of pre-reflective communication between the body and the world. Then, I explore how affect and the notion of a material a priori help resolve certain problems regarding sensation's alleged vagueness and unintelligibility. I conclude by advocating for Merleau-Ponty's notion of radical reflection and supplement it with insights gleaned from the analysis of poly-intentionality.