bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coral microbiome diversity reflects mass coral bleaching susceptibility during the 2016 El Niño heat wave
Authors: Gardner Stephanie G. , Camp Emma F. , Smith David J. , Kahlke Tim , Osman Eslam O. , Gendron Gilberte , Hume Benjamin C. C. , Pogoreutz Claudia , Voolstra Christian R. , Suggett David J. 
Published: January 2019

AbstractRepeat marine heat wave‐induced mass coral bleaching has decimated reefs in Seychelles for 35 years, but how coral‐associated microbial diversity (microalgal endosymbionts of the family Symbiodiniaceae and bacterial communities) potentially underpins broad‐scale bleaching dynamics remains unknown. We assessed microbiome composition during the 2016 heat wave peak at two contrasting reef sites (clear vs. turbid) in Seychelles, for key coral species considered bleaching sensitive (Acropora muricata, Acropora gemmifera) or tolerant (Porites lutea, Coelastrea aspera). For all species and sites, we sampled bleached versus unbleached colonies to examine how microbiomes align with heat stress susceptibility. Over 30% of all corals bleached in 2016, half of which were from Acropora sp. and Pocillopora sp. mass bleaching that largely transitioned to mortality by 2017. Symbiodiniaceae ITS2‐sequencing revealed that the two Acropora sp. and P. lutea generally associated with C3z/C3 and C15 types, respectively, whereas C. aspera exhibited a plastic association with multiple D types and two C3z types. 16S rRNA gene sequencing revealed that bacterial communities were coral host‐specific, largely through differences in the most abundant families, Hahellaceae (comprising Endozoicomonas), Rhodospirillaceae, and Rhodobacteraceae. Both Acropora sp. exhibited lower bacterial diversity, species richness, and community evenness compared to more bleaching‐resistant P. lutea and C. aspera. Different bleaching susceptibility among coral species was thus consistent with distinct microbiome community profiles. These profiles were conserved across bleached and unbleached colonies of all coral species. As this pattern could also reflect a parallel response of the microbiome to environmental changes, the detailed functional associations will need to be determined in future studies. Further understanding such microbiome‐environmental interactions is likely critical to target more effective management within oceanically isolated reefs of Seychelles.
Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects
Authors: Alsalim Wathik , Ahrén Bo 
Published: January 2019

SummaryPeople with repeated rapid meal ingestion have been reported to have increased risk of insulin resistance, impaired glucose tolerance and obesity. To explore whether speed of eating a breakfast influences the postprandial rise of glucose, insulin and the incretin hormones, 24 healthy subjects (12 men and 12 women, mean age 62 years) ingested a standardized solid breakfast consisting of 524 kcal (60% from carbohydrate, 20% from protein, 20% from fat) over 5 or 12 minutes on separate days in random order. Breakfast ingestion increased circulating glucose and insulin with maximal levels seen at 30 minutes after start of meal ingestion with no significant difference in the two tests. Similarly, breakfast increased circulating levels of total (reflecting secretion) glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) with, again, no difference between the tests. Furthermore, gastric emptying, as revealed by the indirect paracetamol test, did not differ between the tests. We therefore conclude that the speed of breakfast ingestion does not affect the postprandial rise of glucose, insulin or incretin hormones in healthy subjects.
Stratigraphy and internal structure of wind‐dominated barrier islands (dune and machair) of the Outer Hebrides, Scotland
Authors: Pile J. , Cooper J.A.G. , Jackson D.W.T. 
Published: January 2019

AbstractThe barrier islands that fringe the western shore of the Outer Hebrides are globally unusual in that they are developed on a planated bedrock (strandflat) surface. They also contain the most extensive area of machair (a distinctive vegetated sandy plain) in the British Isles. This paper presents the first investigation of the internal structure and morphology of these barrier islands and investigates the controls on their structure. The barriers form extensive (300‐1000 metres wide) but thin (1.5‐2 m) surficial deposits typically resting on bedrock. In areas where depressions exist in the bedrock, and where sediment supply permits, transgressive dunes underlie the machair. A distinctive machair facies of sub‐horizontal, undulating reflections, which are laterally continuous over tens of metres is the dominant component of the barriers at each site. This reflects episodic deposition of windblown sand up to the level of the water table. Thereafter any additional sand is transported through the system to accumulate in topographic lows as lake fills, or on topographic highs as ‘high machair’. Eight radar facies were identified, the extent and presence of which vary between the study sites. Bedrock topography and sediment supply are interpreted as the dominant controls on variability in barrier structure. © 2019 John Wiley & Sons, Ltd.
An integrated micromorphological and phytolith study of urban soils and sediments from the Gallo‐Roman town Atuatuca Tungrorum, Belgium
Authors: Wouters Barbora , Devos Yannick , Vrydaghs Luc , Ball Terry , De Winter Natasja , Reygel Patrick 
Published: January 2019

AbstractTongeren is the only Roman administrative capital within the borders of present‐day Belgium. It developed in the first century A.D. and became an important civitas. Many excavations in the center of town have uncovered complex stratigraphic sequences, including dark earths, dating to Roman as well as early medieval times. Their interpretation, based on traditional archaeological methods, often remains problematic. A large‐scale excavation at Vermeulenstraat in 2014 is the first occasion where a geoarchaeological study was conducted using both micromorphology and the study of phytoliths in thin sections. The aim was to evaluate the impact of depositional and post‐depositional processes, to gain an understanding of the formation of the dark earths encountered on the site, to characterize the deposits between and underneath them, and to identify and differentiate human activities and natural phenomena. The results show a range of different activities and events, such as cultivation, construction (including floor preparation), destruction, waste dumping, and gardening. Their different formation histories illustrate the evolution of the area, and their analysis provides an important precedent for the further geoarchaeological study of this town.
Do corporate governance mechanisms and internal control systems matter in reducing mortality rates?
Authors: Afriyie Stephen Owusu , Kong Yusheng , Danso Patrick Obeng , Ibn Musah Abdul‐Aziz , Akomeah Michael Owusu 
Published: January 2019

SummaryInternal controls are critical to guarding an institution against fraud, error, and devastation. They are effective tools for preventing losses and achieving organizational goals. However, internal control mechanisms need to be relevant, because the organization cannot comprehend the effectiveness of the system if they are out‐of‐touch with the operation. Health care control practices are not exceptionally different from what pertains in other industries. The health care organizations require effective corporate governance mechanisms to uphold their operations and performances. These practices assist health care organizations to exhume cynical practices that generate unproductive results and also factors militating against the hospital's goals or objectives. This study revealed that practices such as enhanced Board diligence, Health Professionals on board, financial prudence, and effective communication have the tendency of reducing mortality, if well executed.
Unsupervised hydrologic classification of rivers: Watershed controls on natural and anthropogenic flow regimes, Alabama, USA
Authors: Praskievicz Sarah , Luo Cehong 
Published: January 2019

AbstractWatershed hydrology has often focused on modelling studies of individual watersheds, which consider each river system as unique. Classification is an alternative approach that instead focuses on the similarities among different watersheds. Although both supervised and unsupervised hydrologic classifications have been developed, few previous studies have used classification to assess the degree of anthropogenic modification of hydrologic regime. Here, we conducted an unsupervised hydrologic classification of 189 U.S. Geological Survey gages, including 41 minimally impacted gages from the Hydro‐Climatic Data Network (HCDN), in the five major interstate river basins in the U.S. state of Alabama. For the natural classification, the most significant predictor variables for cluster membership were related to compressive strength of bedrock, bedrock depth, hydraulic conductivity, elevation, temperature, and soil texture, and several land‐cover variables were also significant in the anthropogenic classification. We then developed two random‐forest models: one based on all 189 gages using both natural and anthropogenic variables from the Stream‐Catchment (StreamCat) dataset and one based on the 41 HCDN gages using natural StreamCat variables only. We used the random‐forest models to predict natural and anthropogenic normative hydrologic class for over 158,000 National Hydrography Dataset Plus catchments in the study area. Catchments that changed their class between the natural and anthropogenic classifications can be identified as those that have a large amount of anthropogenic influences on their hydrologic regime, including many catchments on the coast, in the north‐western Coastal Plain, in the Interior Low Plateaus, and in the Piedmont. Using unsupervised hydrologic classifications is a promising approach for uncovering the physical processes that affect hydrologic regime. There are also potential applications in river management, including predicting the hydrologic behaviour of ungaged watersheds, identifying relatively unimpaired rivers to serve as conservation and restoration targets, and regionalization of environmental instream flow standards and climate‐change impacts.
On the role of spatial resolution on snow estimates using a process‐based snow model across a range of climatology and elevation
Authors: Sohrabi Mohammad M. , Tonina Daniele , Benjankar Rohan , Kumar Mukesh , Kormos Patrick , Marks Danny , Luce Charlie 
Published: January 2019

AbstractHydrological processes in mountainous settings depend on snow distribution, whose prediction accuracy is a function of model spatial scale. Although model accuracy is expected to improve with finer spatial resolution, an increase in resolution comes with modelling costs related to increased computational time and greater input data and parameter information. This computational and data collection expense is still a limiting factor for many large watersheds. Thus, this work's main objective is to question which physical processes lead to loss in model accuracy with regard to input spatial resolution under different climatic conditions and elevation ranges. To address this objective, a spatially distributed snow model, iSnobal, was run with inputs distributed at 50‐m—our benchmark for comparison—and 100‐m resolutions and with aggregated (averaged from the fine to the large resolution) inputs from the 50‐m model to 100‐, 250‐, 500‐, and 750‐m resolution for wet, average, and dry years over the Upper Boise River Basin (6,963 km2), which spans four elevation bands: rain dominated, rain–snow transition, and snow dominated below treeline and above treeline. Residuals, defined as differences between values quantified with high resolution (>50 m) models minus the benchmark model (50 m), of simulated snow‐covered area (SCA) and snow water equivalent (SWE) were generally slight in the aggregated scenarios. This was due to transferring the effects of topography on meteorological variables from the 50‐m model to the coarser scales through aggregation. Residuals in SCA and SWE in the distributed 100‐m simulation were greater than those of the aggregated 750 m. Topographic features such as slope and aspect were simplified, and their gradient was reduced due to coarsening the topography from the 50‐ to 100‐m resolution. Therefore, solar radiation was overestimated, and snow drifting was modified and caused substantial SCA and SWE underestimation in the distributed 100‐m model relative to the 50‐m model. Large residuals were observed in the wet year and at the highest elevation band when and where snow mass was large. These results support that model accuracy is substantially reduced with model scales coarser than 50 m.
Revised FIGO staging for carcinoma of the cervix uteri
Authors: Bhatla Neerja , Berek Jonathan S. , Cuello Fredes Mauricio , Denny Lynette A. , Grenman Seija , Karunaratne Kanishka , Kehoe Sean T. , Konishi Ikuo , Olawaiye Alexander B. , Prat Jaime , Sankaranarayanan Rengaswamy 
Published: January 2019

AbstractObjectiveTo revise FIGO staging of carcinoma of the cervix uteri, allowing incorporation of imaging and/or pathological findings, and clinical assessment of tumor size and disease extent.MethodsReview of literature and consensus view of the FIGO Gynecologic Oncology Committee and related societies and organizations.ResultsIn stage I, revision of the definition of microinvasion and lesion size as follows. Stage IA: lateral extension measurement is removed; stage IB has three subgroups—stage IB1: invasive carcinomas ≥5 mm and <2 cm in greatest diameter; stage IB2: tumors 2–4 cm; stage IB3: tumors ≥4 cm. Imaging or pathology findings may be used to assess retroperitoneal lymph nodes; if metastatic, the case is assigned stage IIIC; if only pelvic lymph nodes, the case is assigned stage IIIC1; if para‐aortic nodes are involved, the case is assigned stage IIIC2. Notations ‘r’ and ‘p’ will indicate the method used to derive the stage—i.e., imaging or pathology, respectively—and should be recorded. Routine investigations and other methods (e.g., examination under anesthesia, cystoscopy, proctoscopy, etc.) are not mandatory and are to be recommended based on clinical findings and standard of care.ConclusionThe revised cervical cancer staging is applicable to all resource levels. Data collection and publication will inform future revisions.
Uninformative Anchors Have Persistent Effects on Valuation Judgments
Authors: Yoon Sangsuk , Fong Nathan 
Published: January 2019

Anchoring effects influence a wide range of numeric judgments, including valuation judgments, such as willingness‐to‐pay (WTP). However, prior research has not established whether anchoring only temporarily distorts responses or exerts persistent influence on preferences. This article presents three incentive compatible experiments examining the long‐term effects of random anchoring on WTP. Study 1 evaluated the persistence of anchoring effects over long durations, and showed that the strength of the effect decayed but did not disappear completely even 8 weeks later. In Study 2, a random anchor significantly influenced WTP after one week, regardless of whether WTP was also elicited immediately following the anchoring procedure, showing that consistency motivations do not account for persistence of anchoring effects. Study 3 showed relatively low anchors resulted in more stable valuations, compared with participants who reported WTP with no anchoring procedure. Together with the pattern of decay over time in Study 1, this suggests that anchoring facilitates the “imprinting” of valuation judgments for later retrieval. These studies show that anchoring effects can lead to lasting changes in valuation judgments, providing the first demonstration of long‐term persistence of constructed preferences as a result of an uninformative and arbitrary manipulation.
The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosis
Authors: Ohradanova-Repic Anna , Machacek Christian , Donner Clemens , Mühlgrabner Vanessa , Petrovčíková Eva , Zahradníková Alexandra , Vičíková Kristína , Hořejší Václav , Stockinger Hannes , Leksa Vladimir 
Published: January 2019

Abstract
The plasminogen system is harnessed in a wide variety of physiological processes, such as fibrinolysis, cell migration, or efferocytosis; and accordingly, it is essential upon inflammation, tissue remodeling, wound healing, and for homeostatic maintenance in general. Previously, we identified a plasminogen receptor in the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R, CD222). Here, we demonstrate by means of genetic knockdown, knockout, and rescue approaches combined with functional studies that M6P/IGF2R is up-regulated on the surface of macrophages, recognizes plasminogen exposed on the surface of apoptotic cells, and mediates plasminogen-induced efferocytosis. The level of uptake of plasminogen-coated apoptotic cells inversely correlates with the TNF-α production by phagocytes indicating tissue clearance without inflammation by this mechanism. Our results reveal an up-to-now undetermined function of M6P/IGF2R in clearance of apoptotic cells, which is crucial for tissue homeostasis.
Prescribing errors and adverse drug reaction documentation before and after implementation of e‐prescribing using the Enterprise Patient Administration System
Authors: Al‐Sarawi Fares , Polasek Thomas M. , Caughey Gillian E. , Shakib Sepehr 
Published: January 2019

AbstractBackgroundMedication errors are a leading cause of harm to patients in hospital that can be decreased by electronic medication management systems.AimsThis study determined the effects of electronic prescribing using the Enterprise Patient Administration System (EPAS) on prescribing errors and adverse drug reaction (ADR) documentation in South Australian public hospitals.MethodsA prospective structured medication chart audit was conducted before (in 2012) and after the implementation (in Dec 2014) of EPAS, comparing the paper‐based National Inpatient Medication Chart (NIMC) with prescribing. All inpatients were eligible for inclusion in the study. Prescribing order errors were determined by the percentage of medication orders that had unclear, illegal or unsafe prescriptions. The quality of ADR documentation was assessed by the percentage of patients with correct documentation.ResultsThe total number of prescribing errors before and after the implementation of EPAS was 67.7 and 2.8 per 100 orders, respectively. The frequency of prescribing order errors due to unclear, illegal and unsafe prescriptions decreased to almost zero with EPAS. Prescriptions classified as unsafe due to incorrect dose, route of administration or dosing frequency decreased from 5.8% to 0.03% of medication orders before versus after EPAS implementation (p < 0.0001). Completed ADR documentation was similar between the paper‐based NIMC and EPAS, but the percentage of patients with ADR alerts who required them was 100% in EPAS compared with 27% on the NIMC (p < 0.0001).ConclusionsE‐prescribing using EPAS significantly decreased prescribing errors and increased ADR alerts. Continued implementation of electronic medication management systems is an important approach to improve medication safety.
New Type of Eco‐Friendly Polymeric Dye by Covalently Bonding Anthraquinone into Polyphenylsulfone
Authors: Cui Zengduo , Zhang Haibo , Li Bolong , Jiang Zhenhua , Zhang Yunhe , Li Zhenyu 
Published: January 2019

AbstractEco‐friendly polymeric dyes with excellent thermal stability, good mechanical performance, and robust chemical stability are highly desired for their diverse and practical applications in food, medicine, electronics and aerospace, etc. However, it remains a big challenge to develop them. Herein, a novel type of eco‐friendly polymeric dye is fabricated by covalently bonding anthraquinone chromophores onto polyphenylsulfone at a molecular level. The obtained polymeric dyes exhibit excellent thermal stability, with a weight loss of 5% at temperatures above 500 °C in air and negligible changes in both color appearance and transparency after being treated at 200 °C in air for 8 h, good mechanical performance with a tensile strength around 70 MPa, and robust chemical stability with demonstrated insolubility and very outstanding colorfastness and anti‐permeability against strong acidic or basic solutions for 7 days at room temperature. These outstanding properties make these polymeric dyes suitable for use in harsh conditions, exceeding existing polymeric dyes, which makes them good to use in some special engineering plastics.
Hyperinvasiveness of Listeria monocytogenes sequence type 1 is independent of lineage I‐specific genes encoding internalin‐like proteins
Authors: Gözel Bulent , Monney Camille , Aguilar‐Bultet Lisandra , Rupp Sebastian , Frey Joachim , Oevermann Anna 
Published: January 2019

AbstractListeriosis is a severe disease caused by the opportunistic bacterial pathogen Listeria monocytogenes (L. monocytogenes). Previous studies indicate that of the four phylogenetical lineages known, lineage I strains are significantly more prevalent in clinical infections than in the environment. Among lineage 1, sequence type (ST1) belongs to the most frequent genotypes in clinical infections and behaves hyperinvasive in experimental in vitro infections compared to lineage II strains suggesting that yet uncharacterized virulence genes contribute to high virulence of certain lineage I strains. This study investigated the effect of four specific lineage I genes encoding surface proteins with internalin‐like structures on cellular infection. CNS derived cell lines (fetal bovine brain cells, human microglia cells) and non‐CNS derived cell lines (bovine macrophage cells, human adenocarcinoma cells) that represent the various target cells of L. monocytogenes were infected with the parental ST1 strain and deletion mutants of the four genes. Despite their association with lineage I, deletion of the four genes investigated did not dampen the hyperinvasiveness of the ST1 strain. Similarly, these genes did not contribute to the intracellular survival and intercellular spread of L. monocytogenes ST1, indicating that these genes may have other functions, either during the infection process or outside the host.