bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in Publication and Levels of Evidence in Foot and Ankle International From 2000-2015
Authors: Griffith Matthew , Han Edward , Hattaway Joshua , Huh Jeannie 
Published: September 2018

Category: Other Introduction/Purpose: As the movement towards evidence-based medicine grows and publication rates rise each year, critical analysis of the orthopaedic literature has become increasingly important. To aid readers in assessing the scientific quality of published research, Foot and Ankle International (FAI) began assigning levels of evidence to all clinical articles in 2008. The purpose of this study was to analyze trends in the characteristics and levels of evidence of articles published in FAI between 2000 and 2015. Methods: All articles published in FAI from 2000, 2005, 2010, and 2015 were reviewed and categorized into article type (clinical, basic science, review, or technical tip). Each clinical article was assigned a level of evidence (I-V) and study type (prognostic, therapeutic, economic, or diagnostic). Descriptive information was gathered pertaining to: country of origin, authorship, and funding. Statistical analysis was performed using chi-squared tests to detect any trends in levels of evidence and publication characteristics. Results: 647 articles were reviewed from 2000 to 2015. There was a statistically significant increase in the publication of clinical articles (70% to 83%; p=0.013). The publication of levels I and II evidence significantly increased (2.44% to 13.53%; p=0.002). Although levels III-V evidence also increased (65% to 70.6%, p=1.014), this was not statistically significant. Publications originated from 39 countries, with a significant increase in the proportion of international papers (32.8% to 48%%; p=0.007). The proportion of articles authored by Podiatrists during the study period significantly decreased (3.73% to 1.74%, p=0.035). Finally, there was an increase in funding disclosures during the study period; funding from grants or professional groups rose from 2.44% to 15.9% (p<0.001) and reported funding from commercial sources rose from 0% to 9.41% (p=0.002). Conclusion: The proportion of level I and II studies published in FAI significantly increased from 2000 to 2015. The publication of clinical research rose, with a majority being therapeutic studies. There was a significant increase in articles published by international authors and a significant decrease in articles published by DPMs. During the same time period, there was a rise in the proportion of articles reporting the use of outside funding, both professional and commercial.
Projections for Total Ankle Arthroplasty based upon the National Inpatient Sample
Authors: Gross Christopher , Rabinowitz Justin , Durante Elizabeth 
Published: September 2018

Category: Ankle Arthritis Introduction/Purpose: The utilization of total ankle arthroplasty (TAA) has increased significantly over the past decade. While projections for hip and knee arthroplasty show an exponential increase in demand, there remains a paucity of literature on the projected demand for TAA. Outcomes for TAA show promising results at 10 year follow up and, as a result, the demand for TAA will likely see a significant increase over the next few decades. The purpose of this study is to assess the current trends and future demand of TAA utilization. Methods: National Inpatient Sample (NIS) data from 1997-2014 was used to identify trends in the utilization of TAA. United States Census Bureau data from 1997-2014 was used to identify historical population data and future population estimates. A linear regression model was created using Mathematica v11.3 to project future demand for total ankle arthroplasty. The data was stratified to show past and future trends based on gender and age. Results: The overall utilization rate of TAA increased from 232 procedures in 1997 to 4435 procedures in 2014. Based on our model, the overall demand for TAA is expected to increase by 174 percent to 12,161 procedures by 2045. Stratified by age groups, the number of procedures is predicted to increase by 69% in ages 18-44, 177% in ages 45-64, and 287% in ages 65-84 by 2045. Stratified by gender, males are projected to undergo 7,070 procedures and females are projected to undergo 6,114 procedures in 2045. Conclusion: Improvements in TAA techniques and implants are leading to better long term clinical outcomes following TAA. Based on our projection model, there is going to be a significant increase in demand for TAA by 2045.
Lisfranc ligament anatomical reconstruction surgery is beneficial for chronic Lisfranc injuries
Authors: Hirano Takaaki , Yui Akiyama , Niki Hisateru 
Published: September 2018

Category: Midfoot/Forefoot Introduction/Purpose: Chronic Lisfranc fracture dislocation had been commonly treated with arthrodesis, but were these treatments suitable? The Lisfranc joint has sagittal motion with articular cartilage and functioning as a shock absorber. We reported the middle-term outcomes after performing Lisfranc ligament anatomical reconstruction surgery (LARS), using an optimal route of reconstruction based on anatomical measurements of and biomechanical experiments with cadavers. The purpose of this study is to determine the usefulness of LARS for chronic Lisfranc injuries to preserve the joint function. Methods: We underwent LARS for 8 cases of Chronic Lisfranc injuries (6 males, 2 females) from May 2012 to June 2017. Average age at surgery 26.1 years (18-38), average follow-up period is 28 months (2-46). The reconstruction route was via a burr hole created at a position 6 mm distal to the tarsometatarsal joint on the 2nd metatarsal, and at a depth of 10 mm. A burr hole was then created from the medial cuneiform bone to the 2nd metatarsal bone in a plantar and horizontal direction. The graft tendon was guided through the burr hole from the medial cuneiform bone to the 2nd metatarsal (double-layered side), was looped, and was guided back around the dorsum of the medial cuneiform(single layer) to reconstruct the dorsal ligament. We examined Myerson classification, Kaar evaluation and the postoperative clinical evaluation using Japanese Society for Surgery of Foot (JSSF) midfoot scale. Results: In Myerson classification, Type B2 6 cases and Type C1 2 cases. In Kaar evaluation, transverse instability (TI) 6 cases, longitudinal instability (LI) 2 cases. The average time from injury to surgery is 156 days on average (37-404). JSSF scores averaged 95 points (90-100). X - ray evaluations were almost good, but in 2 cases with weight bearing, a slight diastasis between the base of the first cuneiform and second metatarsal was observed. But there were no clinical symptoms such as pain. In the surgical procedure, scar is mediated in chronic cases. Therefore, we had to take time to obtain the reduction. Conclusion: Arthrodesis is gold standard for chronic Lisfranc joint injuries, but decline in foot flexibility is inevitable. LARS is beneficial for maintaining anatomical reduction, preserving the joint function, and shortening the post-therapy period. LARS gave stable results against Chronic Lisfranc joint injuries. LARS for chronic Lisfranc joint injuries is a useful procedure.
Comparison of internal fixation with hollow two-way compression screw and double Kirschner pin for the treatment of Jones fracture
Authors: John Rodger 
Published: September 2018

Category: Midfoot/Forefoot Introduction/Purpose: To compare the clinical effect of hollow bidirectional compression screw and double Kirschner needle in the treatment of Jones fracture. Methods: 32 cases of Jones fractures treated follow-up were analyzed retrospectively, including 20 cases of application of hollow biaxial compression intramedullary screw fixation for 12 cases, double Kirschner wire internal fixation. Results: all 32 cases were followed up for 6~18 months, with an average of 10 months. For two-way hollow compression screw nail 20 cases, including 19 cases healed, 1 cases of delayed healing, the healing rate was 95%, the average healing time of 11.2 weeks (9 - 13). 12 cases of internal fixation with double Kirschner needle were performed, of which 8 cases were bone healing, 3 cases were delayed union, 1 cases were not healed, the healing rate was 75%, the average healing time was 14.7 (12~16) weeks. The average healing time after two groups of internal fixation was statistically analyzed, and the difference was statistically significant. Conclusion: the hollow two-way compression screw is more reliable and reliable in the treatment of Jones fracture than the double Kirschner wire. The average healing time is shorter and the healing rate is higher. The hollow two-way compression screw is an effective method for the treatment of Jones fracture.
Cost-Utility Analyses in Foot & Ankle Surgery
Authors: Karhade Aditya , Kwon John 
Published: September 2018

Category: Other Introduction/Purpose: Orthopedic surgery lies at the forefront of the initiative to deliver value-based care. As a result, cost utility analyses have gained increased importance in the orthopedic literature. While other authors have previously reviewed the quality of US-based cost-utility analyses in orthopedic trauma, spine, sports, and arthroplasty, a similar analysis specific to foot and ankle surgery has not been performed. As such, the practicing foot and ankle surgeon does not yet have a comprehensive analysis of the available cost-utility analyses or the quality of the available evidence. The purpose of this study was to perform a systematic review of cost-utility analyses in foot and ankle surgery. Methods: A systematic review of foot and ankle studies was conducted to identify cost-utility based analyses published between 2000 and 2017. Of 687 studies screened by abstract, eight cost-utility foot and ankle studies were identified that met inclusion criteria and were scored by the Quality of Health Economic Studies instrument for overall quality. Results: Of the eight studies that met inclusion criteria, four were published in the U.S. Regarding topic, three examined end-stage arthritis, two examined diabetic foot ulcers, two examined ankle fractures and one examined ankle sprains. Cost-effective interventions identified by these studies included total ankle arthroplasty over ankle fusion or nonoperative treatment, adjunctive hyperbaric oxygen therapy for diabetic foot ulcers, suture button fixation over syndesmotic screws for unstable supination-external rotation type IV ankle fractures, and below knee cast and fracture boot immobilization over tubular bandages for acute severe ankle sprains respectively. The mean Quality of Health Economic Studies scores for these studies was 81.9 with interquartile range, 25th percentile score of 74.8 to 75th percentile score of 86. Conclusion: Despite the increasing focus on value-based care delivery, there are few foot and ankle cost-utility analyses in the current literature. Nonetheless, the quality of existing analyses is high as rated by the Quality of Health Economic Studies and certain interventions have been identified as cost-effective as highlighted above. The findings of this review can be used to help design future analyses in order to best demonstrate the cost-effectiveness of foot and ankle interventions.
Optimization of Tenocyte Lineage-Related Factors from Mesenchymal Stem Cells
Authors: Lee Seung Yeol , Kim Hyang , Kwon Soon-Sun 
Published: September 2018

Category: Basic Sciences/Biologics Introduction/Purpose: Researchers should consider various potential factors that affect tenogenic differentiation of MSCs. Numerous experimental settings are associated with high cost and time. Response surface methodology (RSM), a component in the design of experiments (DOE), is gaining recognition as a powerful tool in optimizing conditions for the production of industrially important products such as chemicals and enzymes. The purpose of this study was to access the differential effects of transforming growth factor beta 3 (TGF-β3) on the tenogenesis of tonsil-derived mesenchymal stem cells (T-MSCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) using RSM. Methods: Bone marrow was collected from four patients (mean age: 79.0±2.2) and mononuclear cells were separated. The tonsillar tissues were collected from four patients (mean age: 7.6±0.6). After isolation of MSCs, they were treated with 5ng/ml and 10ng/ml of TGF-β3 with vehicle control. The full-factorial experimental design was employed to study the effect of tension based on T-MSCs. The design was composed of three levels being coded as -1, 0 and +1 and a total of 18 runs were carried out in duplicates to optimize the level of chosen variables, such as days and amount. A total of 84 trials were utilized and fitted with RSM; they were then used to obtain mathematical prediction models. Results: Exposure of TGF-β3 to T-MSCs and BM-MSCs resulted in an increase in the expression of SCX, TNMD, decorin, collagen I, and tenacin C. Most tenocyte lineage-related factors from T-MSCs and BM-MSCs presented a maximum increase in 2- 3 day treatment. Considering all of tenocyte lineage-related factors that we assessed, the predicted value of the factors was significantly induced at 2.7 ng/mL of TGF-β3 (p < 0.001) on 2.5-day culture (p = 0.001). (Fig A) Considering all of tenocyte lineage-related factors that we assessed, the predicted value of the factors was significantly induced on 2.3-day culture (p = 0.004) regardless of the concentration of TGF-β3. (Fig B) Conclusion: We demonstrated that tenocyte-like cells can be successfully differentiated from T-MSCs and BM-MSCs under TGF- β3 stimulation. This study demonstrated that T-MSCs and BM-MSCs in tenogenic stimulation with TGF-β3 have a similar tenogenic differentiation potential using RSM.
Natural Progression of Radiographic Indices in Juvenile Hallux Valgus Deformity
Authors: Lee Seung Yeol , Kwon Soon-Sun , Park Moon Seok , Lee Kyoung Min 
Published: September 2018

Category: Bunion Introduction/Purpose: There is a lack of quantitative studies on the progression of juvenile hallux valgus deformity. Therefore, we performed this study to estimate an annual change of radiographic indices for juvenile hallux valgus. Methods: We reviewed medical records of consecutive patients under the age of 15 with juvenile hallux valgus who underwent weight-bearing foot radiographs more than twice, and were followed over a period of one year or more. A total of 133 feet from 69 patients were included. Hallux valgus angle, hallux interphalangeal angle, intermetatarsal angle, metatarsus adductus angle, distal metatarsal articular angle, anteroposterior talo-1st metatarsal angle, anteroposterior talo-2nd metatarsal angle, and lateral talo-1st metatarsal angle were measured and were used as a study criteria. The progression rate of hallux valgus angle was adjusted by multiple factors including the use of a linear mixed model with gender and radiographic measurements as the fixed effects and laterality and each subject as the random effect. Results: Our results demonstrate that the value of hallux valgus angle on the radiographs progressed as the patients grew older. The hallux valgus angle increased by 0.8° per year (p<0.001)(Figure). The distal metatarsal articular angle also increased by 0.8 per year (p=0.003). Conversely, hallux interphalangeal angle decreased by 0.2° per year (p=0.019). Progression of the intermetatarsal angle and metatarsus adductus angle with aging were not statistically significant. There was a difference in progression of radiographic indices between older patients (≥10 years) and younger patients (<10 years). The hallux valgus angle increased by 1.5° per year (p<0.001) in younger patients, progression of the hallux valgus angle in older patients was not statistically significant (p=0.869) as children grew up. Conclusion: These results suggest that the hallux valgus angle increased in patients with juvenile hallux valgus under 10 years old, unlike the patients aged 10 or older. We believed that our results can help surgeons to determine a treatment strategy that uses the growth potential to achieve correction of deformity such as lateral hemiepiphyseodesis of the 1st metatarsal to patients with juvenile hallux valgus.
Defining A Safe Zone For Percutaneous Screw Fixation Of The Posterior Malleolus
Authors: LeMass Harry , Whitworth Nicholas , Platt Simon 
Published: September 2018

Category: Trauma Introduction/Purpose: Fixation of the posterior malleolar fragment of an ankle fracture confers stability. Not all posterior fragments are displaced, necessitating open reduction. We hypothesised that a safe anatomic corridor is possible for percutaneous screw fixation in some fracture variants. We conducted an anatomic study to determine if percutaneous fixation was possible and safe. This anatomic assessment of significant structures at the posterior ankle, combined with cadaveric dissection following placement of screw tracts shows that percutaneously fixing the posterior malleolus is achievable in medially positioned fragments. Methods: Multiple percutaneous Kirschner wires were passed into a cadaveric ankle specimen at reproducible anatomic points. The wires were passed into typical locations for posterior malleolus fixation. The specimen was dissected and all wires threatening significant structures were removed. A single safe medial passage was identified. The surface anatomy landmarks for the single safe wire was recorded. Multiple (6) cadaveric specimens were further wired via an entry point using only the surface anatomy landmarks previously determined to be safe. These were dissected to confirm the presence of a safe zone for percutaneous wiring of the posterior malleolus. Image intensifier was used to confirm adequate placement of the wire in the posterior malleolus. Results: A safe medial zone for percutaneous fixation of the posterior malleolus was consistent; this was successfully replicated utilising surface anatomy alone. The entry point for safe percutaneous fixation was found to be 1 cm proximal to the tip of the medial malleolus and immediately lateral to the tendo-achilles. Conclusion: A safe passage for percutaneous screw placement for medially located posterior malleolar fragments (Haraguchi I/II) was identified. A safe zone for percutaneous fixation of the posterior malleolus has been newly defined.
Radiographic predictors for improved outcomes after hammertoe correction surgery
Authors: Maidman Samuel , Bariteau Jason , Boden Stephanie , Boden Allison , Tenenbaum Shay 
Published: September 2018

Category: Lesser Toes Introduction/Purpose: Hammertoe deformities are common, often painful deformities of the lesser foot and are known to severely affect daily activities. When patients seek surgical management, x-rays are utilized for diagnosis, evaluation for surgical candidacy, and selection of the operative technique. Postoperatively, radiographs are retaken to assess bone health, healing status, and alignment. Despite the frequent use of radiographs pre- and post-operatively, radiographic results are not necessarily indicative of clinical presentation or surgical outcomes. The aim of this study is to identify specific radiographic parameters that are predictive of improved pain and function after surgical correction of hammertoe deformity. Methods: Prospectively collected data was reviewed on 51 consecutive patients who underwent operative correction of hammertoe deformity. Patient demographics, comorbidities, and post-surgical complications were recorded from their electronic medical records. Clinical outcomes were assessed utilizing preoperative and postoperative Visual Analogue Scale (VAS) and Short Form Health Survey Physical Component (SF-36 PCS) scores with a minimum of six-month follow-up. Radiographs were scored by a foot & ankle fellowship-trained orthopaedic surgeon to assess preoperative severity, postoperative joint fusion, and both pre- and postoperative joint instability and arthritis. Data was examined using a multivariable analysis. Results: Preoperatively, 15.7% (8/51) of patients had a deformity classified radiographically as mild, 37.3% (19/51) as moderate, and 47.1% (24/51) as severe. Additionally, 60.8% (31/51) had joint instability, 17.7% (9/51) had joint dislocation, and 7.8% (4/51) had joint arthritis. Postoperatively, 74.5% had PIP joint fusion, 35.3% (18/51) had joint arthritis, and 9.8% (5/51) had joint instability. A significant association was found between PIP joint fusion and improved SF-36 PCS scores (p=.004). Preoperative anticoagulant therapy was associated with reduced rates of PIP joint fusion (p=0.02). There was no association found between the other demographic or radiographic parameters, and no parameters were associated with improvement in VAS scores. Conclusion: After undergoing surgical correction of hammertoe deformity, postoperative PIP joint fusion was the only variable determined to be indicative of improved physical function. However, pre- and postoperative metatarsophalangeal joint arthritis nor instability was predictive of outcomes. This work informs foot & ankle specialists that healing of the PIP joint is critical to successful hammertoe surgery.
Anatomic Description of the Anterior Body Calcaneal Z-Osteotomy
Authors: McGann Maria , Larson David , Hyer Christopher 
Published: September 2018

Category: Ankle Introduction/Purpose: Flexible pes planovalgus is a common condition encountered by foot and ankle physicians. Many treatment options exist to correct this deformity. One such procedure is an Evans osteotomy of the anterior process of the calcaneus. Due to the complications seen with this type of osteotomy, there has been an attempt to reduce these complications and as a result, an anterior body calcaneal z-cut osteotomy was developed. This osteotomy is inherently more stable by design and fewer complications have been reported. In an attempt to further understand this osteotomy and to determine how much bony interface remained following this osteotomy, a cadaveric study was performed. Methods: A Z-cut osteotomy was performed on 10 cadaveric specimens with the distal arm exiting dorsal and 1 cm proximal to the calcaneocuboid joint, while the proximal arm exited plantarly. The central axis lengths of 15 mm and 20 mm were compared. An 8-mm wedge was placed in both the distal and proximal arms, and fixated with a staple. Digital calipers were used to measure the amount of bony apposition on the central arm between the wedges. Results: The average amount of bone apposition was 9.13 mm. When comparing the 20 mm to 15 mm central arm groups, the average bony apposition was 10.66 mm and 7.61 mm, respectively. Conclusion: Based on these results, the anterior body calcaneal Z-osteotomy provides enough bony apposition between both groups with an 8-mm wedge distraction. Further studies are warranted to evaluate the union rate between the classic lateral column lengthening osteotomy and the anterior body calcaneal Z-osteotomy.