bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Pharmacogenomics “Side-effect” of TP53/EGFR in Non-small Cell Lung Cancer Accompanied with Atorvastatin Therapy: A Functional Network Analysis
Authors: Zhang Lei , Huang Yifang , Gan Xuedong , He Siying , Cheng Xiaohuan , Yang Na , Li Siwei , Li Zuhua , Zheng Fang 
Published: September 2019

Background:
Atorvastatin belongs to the group of statins and is the leading drug for hypercholesterolemia
treatment. Although, its anticancer effects are highly appreciated, its properties are still unclear. The
aim of this study was to explore the underlying anticancer mechanisms induced by atorvastatin and enlarge the
potential target in non-small cell lung cancer.

Methods:
arget genes of atorvastatin were collected by the DrugBank database. Prediction of interaction between
primary targets and secondary targets was performed, and protein-protein interaction network was constructed
though the STRING. Then, KEGG pathway enrichment analysis was performed with WebGestalt and
ClueGO, including the pathways in non-small cell lung cancer. Furthermore, a genomic alteration analysis of the
selected seed genes of atorvastatin benefit and non-small cell lung cancer pathway was conducted by cBioPortal.
Finally, a survival analysis with the selected seed genes in lung cancer (lung adenocarcinoma, lung squamous
cell carcinoma) was conducted using Kaplan-Meier (KM) plotter.

Results:
To identify seed genes, 65 potential candidate genes were screened as targets for atorvastatin using
STRING with DrugBank database, while the KEGG pathway was enriched to get the overlap match of pathways
in non-small cell lung cancer. Then 4 seed genes, Epidermal Growth Factor Receptor (EGFR), erb-b2 receptor
tyrosine kinase 2 (ERBB2), AKT serine/threonine kinase 1 (AKT1) and tumor protein p53 (TP53), were selected
and their genomic alternation were evaluated by cBioPortal. Survival analysis found that TP53 and EGFR
showed a significant correlation (log rank P = 3e-07 and 0.023) with lung adenocarcinoma and lung squamous
cell carcinoma, according to the KM analysis.

Conclusion:
Gene-phenotype connectivity for atorvastatin in non-small cell lung cancer was identified using
functional/activity network analysis method, and our findings demonstrated that TP53 and EGFR could be the
potential targets in cancer patients with atorvastatin therapy.
A Multi-parameter Joint Warning Mechanism for Physical Condition Monitoring System in Physical Education
Authors: Su Zhang 
Published: September 2019

Background:
In recent years, sudden deaths of primary and secondary school students
caused by sports activities have drawn great attention in education and medical circles. It is
necessary for schools to monitor the physical condition of the students in order to reasonably set the
duration of their physical activity. At present, the physical condition monitoring instruments used in
various hospitals are expensive, bulky, and difficult to operate, and the detection process is complicated.
Therefore, existing approaches cannot meet the needs of physical education teachers on
campus for detecting the physical condition of students.

Methods:
This study designs a portable human-physiological-state monitoring and analysis system.
Real-time communication between a wearable measurement device and a monitoring device can be
ensured by real-time detection of the environment and power control of the transmitted signal.

Results:
From a theoretical point of view, the larger the number of segments M, the more significantly
the reduction of false alarm probability. The simulation results also show this fact. Compared
with the conventional early warning mechanism, the probability of a false alarm for the proposed
system is lower, and the greater the number of segments, the faster its reaction speed.

Conclusion:
The portable monitoring system of student physical condition for use in physical
education of primary and middle school students proposed in this paper ensures real-time monitoring
of the members within the system in an open environment, and further proposes an early warning
mechanism for combining multiple vital sign parameters. In addition, the proposed system functions
faster; the average early warning time required is only one-quarter of that of the conventional system.
Hyperspectral Image Data Classification with Refined Spectral Spatial Features Based on Stacked Autoencoder Approach
Authors: Menezes Jacintha , Poojary Nagesh 
Published: September 2019

Background:
Hyperspectral (HS) image data comprises of tremendous amount of spatial
and spectral information which offers feature identification and classification with high accuracy.
As part of the Deep Learning (DL) framework Stacked Autoencoders (SAEs) has been successfully
applied for deep spectral features extraction in high dimensional data. HS deep image feature extraction
becomes complex and time consuming due to the hundreds of spectral bands available in
the hypercubes.

Methods:
The proposed method aims condense the spectral-spatial information through suitable
feature extraction and feature selection methods to reduce data dimension to an appropriate scale.
Further, the reduced feature set is processed by SAE for final feature representation and classification.

Results:
The proposed method has resulted in reduced computation time by ~ 300s and an improvement
in classification accuracy by ~15% as compared to uncondensed spectral-spatial features
fed directly to SAE network.

Conclusion:
Future research could explore the combination of most state-of-the art techniques.
Dual-Band Flexible Antenna for WLAN/WiMAX Applications
Authors: Thanki Poonam , Raval Falguni 
Published: September 2019

Aim:
This paper presents the development of Co-Planar Waveguide (CPW) fed dualband,
compact, and flexible antenna. The antenna is designed on flexible substrate jeans; so, it is
suitable for wearable applications.

Objective:
The proposed antenna generates dual-band at 3.36GHz –3.61GHz and at 5.01 GHz –
5.18 GHz. The antenna has a compact size of 40×30 mm2. The antenna consists of a rectangular
patch having a slot which is responsible for the first band and slot in the ground plane which is responsible
for the second band.

Methods:
By optimizing the dimensions, the antenna gives dual-band at 3.5 GHz and 5.1 GHz
with impedance bandwidth of 250 MHz and 170 MHz, respectively. The performance of the antenna
such as gain and radiation pattern over the operating band has been also discussed.

Conclusion:
This proposed antenna with the first band at 3.5GHz is suitable for Wi-MAX
(Worldwide Interoperability for Microwave Access) and second band at 5.1GHz is suitable for
Higher Wireless Local Area Network applications (WLAN).
Removal of Pb(II) from Aqueous Solutions by Adsorption Using Nano Mesoporous Silica MCF Adsorbent: Kinetic, Thermodynamic, Isotherm and Equilibrium Studies
Authors: Zhai Qing-Zhou 
Published: September 2019

Introduction:
Pb2+ is a very toxic heavy metal and its pollution to environment is very
harmful and to remove its pollution is a very important issue.

Methods:
In this work, nano Mesocellular Foams (MCF) silica material was synthesized by hydrothermal
method in this research. Power X-ray diffraction and scanning electron miccroscopy, etc.
were used to characterize the sample. In this paper, the adsorption of heavy metal ion Pb2+ by MCF
was studied.

Results:
The sample showed spherical particles and the morphology was regular. Its average particle
diameter was 2.2 μm. Transmission electron microscopic result showed that the structure of the
MCF synthesized has honeycomb structure pore channels which are benefitial for adsorbing heavy
metal ions. The nitrogen adsorption-desorption experimental results at low temperature of 77 K
showed that the adsorption pore diameter of the MCF synthesized was 19.62 nm. The research results
showed that when pH value was 4.5, temperature was 25 ± 1°C, the adsorbent material MCF was
0.2000 g:Pb2+ = 5 and the contact time was 40 min, the adsorption effect was the best and the adsorption
rate reached 97.16 ± 0.03%, while the adsorption capacity reached 194.32 ± 0.13 mg/g.

Conclusion:
By studying, it has been found that the adsorption belongs to the quasi-second-order
kinetic model, simultaneously, it also fits the Freundlich equation and in accordance with heterogeneous
adsorption. The results of adsorption thermodynamics showed that when temperature is
25 ~ 45°C, the adsorption is a spontaneous exothermic reaction, ΔG° is less than zero, the adsorption
enthalpy ΔH° is -31.856 kJ/mol and the adsorption entropy change ΔS° is -45.092 J/(mol·K).
The Effect of CoFe2O4 Weight Fraction on the Properties of Magnetic CoFe2O4/Unsaturated Polyester Nanocomposites Synthesized by Hand Lay-up Method
Authors: Jabbar Rihab , Hameed Awham M. , Sabeeh Sabah H. 
Published: September 2019

Objective:In this study, Cobalt ferrite (CoFe2O4) nanopowders were prepared by the sol-gel precipitation method.Methods:The prepared ferrite powders were sintered at 1000°C for 2 hours. CoFe2O4/unsaturated polyester nanocomposites were prepared with different weight fraction of CoFe2O4. The X-ray diffraction results showed that the crystallite size (D) of CoFe2O4was found to be 20.68 nm. Fouriertransform infrared spectroscopy (FTIR) spectra confirmed the spinal structure of CoFe2O4.Results:The saturation magnetization (Ms) and coercivity (Hc) of all the composites were found to increase with increasing ferrite content.Conclusion:Dielectric constant values were found to increase with increasing the concentration of ferrite.
Photo-catalytic Study of Malachite Green Dye Degradation Using Rice Straw Extracted Activated Carbon Supported ZnO Nano-particles
Authors: El-Salamony Radwa A. , Emam Abeer A. , Badawy Nagwa A. , El-Morsi Sara F. 
Published: September 2019

Objective:
ZnO nanoparticles were synthesized using wet impregnation method, and
activated carbon from rice straw (RS) prepared through chemical route.

Methods:
The nano-composites ZnO-AC series were prepared with different ZnO:AC ratio of 10,
20, 50, and 70% to optimize the zinc oxide nanoparticles used. The obtained composites were
characterized by FE-SEM, XRD, SBET, and optical techniques then used for the photo-degradation
of Malachite green dye (MG) under visible light.

Results:
It was found that 10ZnO-AC exhibited excellent visible light photo-catalytic performance.
The ·OH radicals’ formation is matching with photo-activity of the prepared composites.
The photo-degradation efficiency of MG increased from 63% to 93%, when the 10ZnO-AC photocatalyst
amount was increased from 0.5 to 6 g/L.

Conclusion:
The GC-MS technique was used to analyze the intermediates formed; up to 15 kinds
of chemicals were identified as the degradation products.
Green Synthesis of Metal Nanoparticles from Adiantum Frond: Comparative Analysis on Cancer Cell Lines
Authors: Zamani Sabiha , Idrees Danish , Jha Babita , Jha Anal K. 
Published: September 2019

Background::
At the present time, silver and gold nanoparticles are emerging as promising
agents for cancer therapy. The anticancer activities of these nanoparticles have been evaluated
against numerous human cancer cell lines. Still, few reports were existing against the breast cancer
cell lines and most of these studies have mainly used chemically mediated nanoparticles.

Objective::
This study reports the in vitro anticancer activity of bioinspired Nanoparticles like,
silver and gold against MCF-7 cells (breast cancer cell line) as well as HEK293 cell (human embryonic
kidney cell line) by MTT assay.

Methods:
These metal nanoparticles, Ag-NPs and Au-NPs were biologically synthesized using
Adiantum sp. aqueous leaves extract. The Adiantum sp. can reduce HAuCl4 solution to Au-NPs
and AgNO3 to Ag-NPs within 30 mins. The formation of NPs was confirmed by characterization
techniques such as UV-vis spectrophotometer, SEM and XRD studies. Additionally, the anticancer
activity was analysed by cell viability (3(4,5-dimethly-thiazol-2-yl)- 2,5-diphenyl tetrazo-lium
bromide assay).

Results:
The synthesized nanoparticles from Adiantum sp. were characterized by UV-visible spectroscopy.
The role of functional groups was analysed using a Fourier Transform Infrared (FTIR)
spectrophotometer. The XRD pattern clearly exemplified that the nanoparticles formed in this present
synthesis are crystalline in nature. Furthermore, in MTT assay study, both NPs have shown
cytotoxicity at different concentrations ranging from 2.5 to 100 μg/ml. The data reveal that the NPs
from Adiantum explicitly, inhibits the viability of cancerous cell only and are non-cytotoxic to
HEK293 cells in the tested concentration range.

Conclusion:
The results provide a preliminary guidance that Adiantum mediated silver and gold
nanoparticles might be used to treat breast cancer; however, it necessitates clinical studies to ascertain
their potential as anticancer agents.
Inorganic-organic Nanomaterials for Therapeutics and Molecular Imaging Applications
Authors: Aljabali Alaa A.A. , Obeid Mohammad A. 
Published: September 2019

Background::
Surface modification of nanoparticles with targeting moieties can be
achieved through bioconjugation chemistries to impart new Functionalities. Various polymeric
nanoparticles have been used for the formulation of nanoparticles such as naturally-occurring
protein cages, virus-like particles, polymeric saccharides, and liposomes. These polymers have
been proven to be biocompatible, side effects free and degradable with no toxicity.

Objectives::
This paper reviews available literature on the nanoparticles pharmaceutical and medical
applications. The review highlights and updates the customized solutions for selective drug
delivery systems that allow high-affinity binding between nanoparticles and the target receptors.

Methods::
Bibliographic databases and web-search engines were used to retrieve studies that assessed
the usability of nanoparticles in the pharmaceutical and medical fields. Data were extracted
on each system in vivo and in vitro applications, its advantages and disadvantages, and its ability to
be chemically and genetically modified to impart new functionalities. Finally, a comparison
between naturally occurring and their synthetic counterparts was carried out.

Results::
The results showed that nanoparticles-based systems could have promising applications in
diagnostics, cell labeling, contrast agents (Magnetic Resonance Imaging and Computed Tomography),
antimicrobial agents, and as drug delivery systems. However, precautions should be taken
to avoid or minimize toxic effect or incompatibility of nanoparticles-based systems with the biological
systems in case of pharmaceutical or medical applications.

Conclusion::
This review presented a summary of recent developments in the field of pharmaceutical
nanotechnology and highlighted the challenges and the merits that some of the nanoparticles-
based systems both in vivo and in vitro systems.
Impact of the Precoagulation Performance of the Ultrafiltration Process in the Tertiary Treatment for Recycling of Urban Sewage
Authors: Lilia Mazari , Djamal Abdessemed 
Published: September 2019

Background:
Ultrafiltration membrane processes have become an established
technology in the treatment and reuse of secondary effluents. Nevertheless, membrane fouling
arises as a major obstacle in the efficient operation of these systems.

Aim/Objective:
This study evaluates the factors affecting pretreatment conditions for combination
ultrafiltration membrane processes for reuse of secondary effluent from the sewage
treatment plant. The objective of this work is to study the precoagulation effect on the removal
of organic matter from secondary effluent from the wastewater treatment plant
Reghaïa (Algiers) and for fouling of the membranes ultrafiltration.

Methods:
A comparison was made between two coagulant FeCl3 and Fe2(SO4)3 using two
processing systems, Coagulation (with sedimentation) / Ultrafiltration and Coagulation
(without sedimentation) / Ultrafiltration. The optimum conditions for coagulation were determined
by the analysis UV254 and turbidity.

Result:
The results showed that there's a better reduction of the decrease of permeate flux
(Jv) in the coagulation system (without sedimentation)/Ultrafiltration for both coagulants
because of trapping of organic molecules responsible for fouling of the membrane inside the
porous flocs formed in the coagulation.
Multi-objective Charging and Discharging Optimization of Electric Vehicles in Time-divided period Based on SOC Evolution
Authors: Wang Ying , Ma Gang , Chen Yixi , Zhang Jian , Wang Jiashu 
Published: September 2019

Background:
With the increase of Electric Vehicle (EV), their disordered charging behaviour
will put great pressure on the stable operation of the distribution network.

Methods:
In order to study the charging and discharging optimization scheme of EVs, firstly the EV
charging and discharging load model is founded based on the Vehicle-to-Grid (V2G) technology.

Results:
According to the electricity price mechanism of Shanxi Province, the paper proposes a
multi-target charging and discharging optimization for EVs based on the evolution of EV State of
Charge (SOC) using the Modified Particle Swarm Optimization (MPSO).

Conclusion:
Compared with the disordered charging mode, the method proposed in this paper can
simultaneously reduce the network loss of the distribution network and the cost of EV users.
"Green" Synthesis of Cerium Oxide Particles in Water Extracts Petroselinum crispum
Authors: Korotkova Аnastasia Mikhailovna , Borisovna Polivanova Oksana , Aleksandrovna Gavrish Irina , Bagdasarovna Kosyan Dianna , Vladimirovich Bagrov Dmitry , Vladimirovich Klinov Dmitry , Alexandrovich Fenin Anatoly , Yurievna Koroleva Marina , Nikolaevna Baranova Ekaterina , Aleksandrovich Ksenofontov Dmitry , Yurievich Cherednichenko Mikhail , Valerievich Lebedev Svyatoslav 
Published: September 2019

Background:Synthesis of metal oxides nanoparticles with specific morphology and size has become the subject of many experimental protocols. Biosynthesis of the nanoparticles using plants is more preferable than physical and chemical methods because of its environmental friendliness.Objective:The purpose of this study was to report the potential for green synthesis of cerium oxide nanoparticles using plant extracts with a high content of phenolic metabolites.Methods:We have synthesized the CeO2 nano- and microparticles using Petroselinum crispum aqueous extract. The particles were characterized by UV-visible spectroscopy, IR spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscope (TEM) and dynamic light scattering analysis. For detection the reduction capacity of the extract the evaluation of total phenolic and flavonoid content as well as high-performance liquid chromatography-mass spectrometry (HPLC-MS) were performed. Biological activity of the particles was identified by bioluminescent tests and bio tests with Triticum vulgare.Results:Testing on T. vulgare showed that biogenic cerium dioxide powders stimulated the growth of up to 5-11,4% relative to intact samples, significantly increased the length of the leaves of seedlings and the root length. When seedings were exposed to the biosynthesized CeO2 particles, the level of chlorophylls was more stable and even slightly higher than control. Noticeable protective properties of the biosynthesized CeO2 powder under oxidation conditions were observed on the plant T. vulgare after a brief exposure (from 4 to 24 h).Conclusion:Thus, biogenic CeO2 can be potentially utilized in oxidative damage protection of agricultural plants.
Heterogeneous Fenton Catalytic Removal of Organic Pollutant in Aqueous Solution by using Coal Gangue as a Catalyst
Authors: Zhang Jiwei , Xu Jingjing , Liu Shuaixia , Gu Baoxiang , Chen Feng , Zheng Qiming , Li Chaoyang 
Published: September 2019

Background:
Coal gangue was used as a catalyst in heterogeneous Fenton process
for the degradation of azo dye and phenol. The influencing factors, such as solution pH
gangue concentration and hydrogen peroxide dosage were investigated, and the reaction
mechanism between coal gangue and hydrogen peroxide was also discussed.

Methods:
Experimental results showed that coal gangue has the ability to activate hydrogen
peroxide to degrade environmental pollutants in aqueous solution. Under optimal conditions,
after 60 minutes of treatment, more than 90.57% of reactive red dye was removed, and the
removal efficiency of Chemical Oxygen Demand (COD) up to 72.83%.

Results:
Both hydroxyl radical and superoxide radical anion participated in the degradation
of organic pollutant but hydroxyl radical predominated. Stability tests for coal gangue were
also carried out via the continuous degradation experiment and ion leakage analysis. After
five times continuous degradation, dye removal rate decreased slightly and the leached Fe
was still at very low level (2.24-3.02 mg L-1). The results of Scanning Electron Microscope
(SEM), energy dispersive X-Ray Spectrometer (EDS) and X-Ray Powder Diffraction (XRD)
indicated that coal gangue catalyst is stable after five times continuous reuse.

Conclusion:
The progress in this research suggested that coal gangue is a potential nature
catalyst for the efficient degradation of organic pollutant in water and wastewater via the
Fenton reaction.
Preto lá faz faculdade? Uma revisão da literatura sobre racismo nas universidades brasileiras
Authors: Coelho Ingrid Mesquita , Lima Alves Rosemary Amanda , De Souza Daniel Cerdeira , Honorato Eduardo Jorge Sant'Ana 
Published: September 2019

RESUMO Consideramos racismo, o sistema construído historicamente que, a partir da raça, classifica os sujeitos em inferiores e superiores. A partir desses constructos, negros foram colocados em um lugar de inferioridade por toda a história. Objetivamos discutir a incidência do racismo nas universidades brasileiras a partir de uma revisão de literatura em artigos científicos publicados entre 2012-2017 e elaboramos um protocolo para análise descritiva dos achados. Como resultados, percebemos a criação do sistema de cotas para o combate da desvantagem no acesso à universidade, mas poucas ações para o combate do racismo institucional que aflige essa população. O discurso meritocrático ainda é o principal argumento contra as cotas. Palavras-chave: Racismo; Universidades Brasileiras; Desigualdades. ABSTRACT We consider racism, the historically constructed system that, from the race, classifies the subjects into inferiors and superiors. From these constructs, blacks have been placed in a place of inferiority throughout history. We aim to discuss the incidence of racism in Brazilian universities based on a review of the literature in scientific articles published between 2012-2017 and elaborated a protocol for descriptive analysis of the findings. As results, we perceive the creation of the quota system to combat disadvantage in access to university, but few actions to combat institutional racism that afflicts this population. Meritocratic discourse is still the main argument against quotas. Keywords: Racism; Brazilian Universities; Inequalities. RESUMEN Consideramos racismo, el sistema construido históricamente que, a partir de la raza, clasifica a los sujetos en inferiores y superiores. A partir de esos constructos, negros fueron colocados en un lugar de inferioridad por toda la historia. Objetivamos discutir la incidencia del racismo en las universidades brasileñas a partir de una revisión de literatura en artículos científicos publicados entre 2012-2017 y elaboramos un protocolo para análisis descriptivo de los hallazgos. Como resultados, percibimos la creación del sistema de cuotas para el combate de la desventaja en el acceso a la universidad, pero pocas acciones para el combate del racismo institucional que aflige a esa población. El discurso meritocrático sigue siendo el principal argumento contra las cuotas.Palabras clave: Racismo; Universidades Brasileñas; Desigualdades. DOI: http://dx.doi.org/10.22169/revint.v14i32.1563