bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encapsulation of nitride phosphors into sintered phosphate glass by pressureless firing and hot isostatic pressing
Authors: Kudo Soichiro , Kishioka Akira , Kuwahara Hideki , Kuroe Haruhiko , Hintzen Hubertus T. , Itatani Kiyoshi 
Published: August 2018

AbstractThe encapsulation conditions of Eu2+‐doped calcium silicon nitride ((Ca0.90Eu0.10)2Si5N8) and strontium silicon nitride ((Sr0.98Eu0.02)2Si5N8) phosphors into phosphate glass ((50‐x)Na2O–xZnO–5B2O3–45P2O5; x = 10‐40) were examined by pressureless sintering (normal or infrared firing) and subsequent oxygen‐assisted hot isostatic pressing. The evaluation of water resistivity, as well as glass transition temperature (Tg), indicated that the excellent water resistivity and low Tg (313°C) could be achieved at x = 30. The colorless and clear glass body could be fabricated by infrared firing at 370°C for 20 minutes in air, followed by the hot isostatic pressing at 370°C for 24 hours (80%Ar + 20%O2, pressure: 130 MPa). The encapsulations of 3.0 mass% (Ca0.90Eu0.10)2Si5N8 and (Sr0.98Eu0.02)2Si5N8 into the glass body produced reddish orange light emission (peak wavelength: 604 nm under excitation wavelength of 423 nm) and red‐light emission (617 nm under 383 nm), respectively, showing higher chemical and thermal stability of nitride phosphors in the glass matrix.
Synthesis and photoluminescence properties of a novel red phosphor SrLaGaO4:Mn4+
Authors: Jiang Chunyan , Zhang Xin , Wang Jia , Zhao Quanzhong , Wong Ka‐Leung , Peng Mingying 
Published: August 2018

AbstractA novel Mn4+‐doped strontium lanthanum gallate red phosphor SrLaGaO4:Mn4+has been successfully prepared via the conventional solid‐state reaction method. Phase purity, photoluminescence excitation/emission spectra, concentration quenching, decay curves, and temperature‐dependent photoluminescence have been investigated systematically. SrLaGaO4:Mn4+phosphor exhibits broad excitation band from 250 to 600 nm and emits intense red light centered at 716 nm arising from spin‐forbidden transition,2E →4A2of Mn4+. The optimal dopant concentration of Mn4+is determined to be 0.2 mol%. Dipole‐dipole interaction is supposed to be the mechanism of concentration quenching. The crystal‐field strength Dq, the Racah parameters B and C, and the nephelauxetic ratioβ1of SrLaGaO4:Mn4+have been calculated according to its luminescent spectra. Our systematic investigation on this new phosphor can provide a reference for the development of red‐emitting phosphor.
Effect of valenced vicarious online contact on out‐group prejudice and perceived out‐group variability: A study of online poker
Authors: Andrews Nadia P. , Yogeeswaran Kumar , Walker Matt J. , Hewstone Miles 
Published: August 2018

AbstractOnline poker has become a multibillion dollar industry, with millions of people from around the world both playing and watching online poker each year. Unlike live poker, players and watchers, typically cannot rely on physical cues of other players; in fact, the only information often available to poker players is others’ nationality. Because these poker games often involve members of different national groups, it constitutes a context of indirect contact that has considerable potential to examine how attitudes and beliefs about people from other nationalities can be influenced by interactions in online poker. In the current research, we examined how observing an in‐group player have positive or negative contact with a player of another nationality impacted one’s own attitudes and beliefs about the out‐group nation. Participants (N = 157) watched an online poker video recording of a fellow in‐group member have negative, positive, or no intergroup contact with an out‐group member at an online poker table. Subsequent affective (out‐group attitudes) and cognitive (perceived out‐group variability) measures of intergroup bias were taken. Data revealed that while observing negative contact increased out‐group prejudice, observing positive contact reduced prejudice (all relative to no intergroup contact). However, no differences were found in perceived out‐group variability. Implications for online poker and future research intergroup contact are discussed.
Identity‐centrality, dimensions of uncertainty, and pursuit of subgroup autonomy: The case of Sardinia within Italy
Authors: Wagoner Joseph A. , Antonini Matteo , Hogg Michael A. , Barbieri Barbara , Talamo Alessandra 
Published: August 2018

AbstractAlthough group‐related uncertainties have been shown to drive subgroups’ pursuit of autonomy, it is unclear whether all group‐related uncertainties motivate subgroup autonomy. We hypothesized that social identity‐uncertainty, not politico‐economic uncertainty, about one’s subgroup is a key driver of support for subgroup autonomy. We measured Sardinian participants’ (N = 174) relative subgroup (Sardinian) and superordinate group (Italian) identity‐centrality, identity‐uncertainty, and politico‐economic uncertainty to predict support for subgroup autonomy and superordinate group fragmentation. Results showed that subgroup identity‐uncertainty, not politico‐economic uncertainty, elicited stronger support for subgroup autonomy, especially among highly identified subgroup members. Superordinate group fragmentation was predicted by relatively weaker superordinate identity‐centrality. Results suggest that subgroups’ pursuit of autonomy is driven by the hopes of reducing identity‐uncertainty.
Is proximal coronary sinus involved in the circuit in some cases of ECG “typical” atrial flutter?
Authors: De Sisti Antonio , Andronache Marius , Damiano Pamela , Eschalier Roman , Font Manuel 
Published: August 2018

AbstractAimIt is commonly conceived that coronary sinus (CS) participates in atrial flutter (AFL) circuit but limited to the fibers surrounding its ostium. We evaluated the involvement of proximal CS in typical AFL.MethodsTwenty AFL patients underwent entrainment mapping using postpacing interval minus AFL cycle length (PPI‐AFL CL) including CS where a decapolar catheter was positioned with proximal bipole 1 cm from the ostium.ResultsWe compared patients with proximal CS within the circuit (group 1, PPI‐AFL CL ≤ 20 ms + concealed entrainment) and those without (group 2, PPI‐AFL CL > 20 ms). Group 1 patients were older, 77.5 ± 4 vs 71 ± 12 years (P < 0.05). No difference was found in AFL CL, PPI‐AFL CL at cavotricuspid isthmus (CTI) entry, plateau, and septal site. Group 1 patients had shorter PPI‐AFL CL at proximal CS (9 ± 3 vs 40 ± 15 ms; P < 0.001) and fragmented mesodiastolic CS atrial potentials (APs) (106 ± 27 vs 58.5 ± 22 ms; P < 0.001). A mid‐septal unexcitable scar was found in five of eight group 1 patients vs one of 12 group 2 patients (P < 0.05). All were ablated at CTI. A patient had AFL recurrence and underwent a second attempt: PPI‐AFL CL was 60 ms at CTI entry and less than or equal to 20 ms at septal CTI and proximal CS; AFL was terminated 1 cm inside CS, applying RF at a fragmented AP.ConclusionProximal CS appears to be involved in a substantial subset of typical AFL patients, in whom advanced age, fragmented CS APs, and the presence of right atrial scar are prevalent. Proximal CS might be considered as an un‐“innocent by‐stander,” but able, in rare cases, to generate a second AFL circuit.
TRIM32 promotes cell proliferation and invasion by activating β‐catenin signalling in gastric cancer
Authors: Wang Changming , Xu Jiapeng , Fu Hongbing , Zhang Yu , Zhang Xin , Yang Dejun , Zhu Zhenxin , Wei Ziran , Hu Zunqi , Yan Ronglin , Cai Qingping 
Published: August 2018

AbstractThe tripartite motif (TRIM) family comprises more than 70 members involved in the regulation of many cellular pathways. TRIM32 acts as an E3 ubiquitin ligase and has been reported to participate in many human cancers. Here, we aimed to investigate the role of TRIM32 in gastric cancer (GC) and the clinical implications. High expression of TRIM32 was observed in GC tissues and cell lines, and was significantly associated with poor prognosis. Knockdown TRIM32 expression remarkably suppressed the proliferation, migration, and invasion of GC cells in vitro and tumour growth in vivo, whereas overexpression of TRIM32 yielded the opposite results. Western blotting and quantitative reverse‐transcription PCR (qRT‐PCR) analyses revealed that up‐regulation of TRIM32 significantly enhanced expression of β‐catenin protein and of its downstream targets TCF1, cyclin D1, Axin2 and MMP7 mRNAs. Moreover, we found that the mechanism behind the TRIM32‐promoted GC progression was related to the β‐catenin signalling pathway. Collectively, these data suggest that TRIM32 promotes GC cell proliferation, migration, and invasion by activating the β‐catenin signalling pathway.
The emerging role of miR‐19 in glioma
Authors: Wang Weihan , Zhang Anling , Hao Yubing , Wang Guangxiu , Jia Zhifan 
Published: August 2018

AbstractGlioma has been regarded as the most common, highly proliferative and invasive brain tumour. Advances in research of miRNAs in glioma are toward further understanding of the pathogenesis of glioma. MiR‐19, a member of miR‐17~92 cluster, was reported to play an oncogenic role in tumourigenesis. Here we review the identified data about the effect of miR‐19 on proliferation, apoptosis, migration and invasion of glioma cells, the target genes regulated by miR‐19, and correlation of miR‐19 with the sensitivity of glioma cells to chemotherapy and radiotherapy. It is concluded that miR‐19 plays an important role in the pathogenesis of glioma and can be a potential target for gene therapy of glioma.
The lysine acetyltransferase GCN5 contributes to human papillomavirus oncoprotein E7‐induced cell proliferation via up‐regulating E2F1
Authors: Qiao Lijun , Zhang Qishu , Zhang Weifang , Chen Jason J. 
Published: August 2018

AbstractGeneral control nondepressible 5 (GCN5), the first identified transcription‐related lysine acetyltransferase (KAT), is an important catalytic component of a transcriptional regulatory SAGA (Spt‐Ada‐GCN5‐Acetyltransferase) and ATAC (ADA2A‐containing) complex. While GCN5 has been implicated in cancer development, its role in cervical cancer is not known. The human papillomavirus (HPV) oncoprotein E7 abrogates the G1 cell cycle checkpoint and induces genomic instability, which plays a central role in cervical carcinogenesis. In this study, we observed that GCN5 was up‐regulated in HPV E7‐expressing cells, knockdown of GCN5 inhibited cell cycle progression and DNA synthesis in HPV E7‐expressing cells. Notably, GCN5 knockdown reduced the steady‐state levels of transcription factor E2F1. Depletion of E2F1 caused G1 arrest while overexpression of E2F1 rescued the inhibitory effects of GCN5 knockdown on G1/S progression in HPV E7‐expressing cells. Results from chromatin immunoprecipitation (ChIP) assays demonstrated that GCN5 bound to the E2F1 promoter and increased the extent of histone acetylation within these regions. GCN5 also acetylated c‐Myc and increased its ability to bind to the E2F1 promoter. Knockdown of c‐Myc reduced the steady‐state levels of E2F1 and caused G1 arrest. These results revealed a novel mechanism of E7 function whereby elevated GCN5 acetylates histones and c‐Myc to regulate E2F1 expression and cell cycle progression.
Functional adenosine triphosphate‐sensitive potassium channel is required in high‐carbohydrate diet‐induced increase in β‐cell mass
Authors: Murase Masatoshi , Seino Yusuke , Maekawa Ryuya , Iida Atsushi , Hosokawa Kaori , Hayami Tomohide , Tsunekawa Shin , Hamada Yoji , Yokoi Norihide , Seino Susumu , Hayashi Yoshitaka , Arima Hiroshi 
Published: August 2018

AbstractAims/IntroductionA high‐carbohydrate diet is known to increase insulin secretion and induce obesity. However, whether or not a high‐carbohydrate diet affects β‐cell mass (BCM) has been little investigated.Materials and MethodsBoth wild‐type (WT) mice and adenosine triphosphate‐sensitive potassium channel‐deficient (Kir6.2KO) mice were fed normal chow or high‐starch (ST) diets for 22 weeks. BCM and the numbers of islets were analyzed by immunohistochemistry, and gene expression levels in islets were investigated by quantitative real‐time reverse transcription polymerase chain reaction. MIN6‐K8 β‐cells were stimulated in solution containing various concentrations of glucose combined with nifedipine and glimepiride, and gene expression was analyzed.ResultsBoth WT and Kir6.2KO mice fed ST showed hyperinsulinemia and body weight gain. BCM, the number of islets and the expression levels of cyclinD2 messenger ribonucleic acid were increased in WT mice fed ST compared with those in WT mice fed normal chow. In contrast, no significant difference in BCM, the number of islets or the expression levels of cyclinD2 messenger ribonucleic acid were observed between Kir6.2KO mice fed normal chow and those fed ST. Incubation of MIN6‐K8 β‐cells in high‐glucose media or with glimepiride increased cyclinD2 expression, whereas nifedipine attenuated a high‐glucose‐induced increase in cyclinD2 expression.ConclusionsThese results show that a high‐starch diet increases BCM in an adenosine triphosphate‐sensitive potassium channel‐dependent manner, which is mediated through upregulation of cyclinD2 expression.
A competitive environment influences sperm production, but not testes tissue composition, in house mice
Authors: Firman Renée C. , Garcia‐Gonzalez Francisco , Simmons Leigh W. , André Gonçalo I. 
Published: August 2018

AbstractDue to the physiological cost of sperm production, males are expected to be prudent in their expenditure and adjust their investment according to current social conditions. Strategic adjustments in sperm expenditure during development can be made via changes in testes size, sperm production rates or testes tissue composition. Here, using house mice, we test the hypothesis that elevated sperm production is driven by a plastic response in the spatial organization of the testes. We reared males under different social conditions (competitive vs. noncompetitive) and quantified sperm number and the proportion of sperm‐producing tissue within the testes. Further, because sperm quality is a critical determinant of competitive fertilization success, we used computer‐assisted sperm analysis to quantify six sperm motility traits. Our investigation revealed that males reared in an environment with a perceived risk of reproductive competition produced more sperm in the absence of changes in testes morphology. We discuss this result in relation to fixed and flexible phenotypically plastic responses to future competitive conditions, and conclude that adaptive adjustments in sperm number in response to the social environment are likely attributable to variation in sperm production rate. Further, we found no difference in in vitro sperm motility parameters among males from the different social environment regimes. Overall, this investigation improves our understanding of the mechanisms of male plastic responses to reproductive competition experienced during sexual development.
Technological and organizational capital: Where complementarities exist
Authors: Stucki Tobias , Wochner Daniel 
Published: August 2018

AbstractThis study analyzes the complementarities between technological and organizational capital within enterprises. Different components of technological and organizational capital exert distinct—and often opposed—forces on each other. Our empirical results show that greater employee voice promotes firm productivity when combined with information technology, but harms firm productivity when combined with communication technology. On the other hand, flexible work design is positively associated with communication technology and negatively associated with information technology.
The Dynamics of Replication in Trypanosoma cruzi Parasites by Single‐Molecule Analysis
Authors: de Araujo Christiane B. , Calderano Simone G. , Elias Maria Carolina 
Published: August 2018

AbstractHere, we investigated the features of replication in Trypanosoma cruzi epimastigotes based on fork speed progression, which is influenced by distinct features such as DNA polymerase rate, susceptibility to DNA damage and repair, secondary structures, transcription and chromatin state. Although T. cruzi exhibits a mean fork speed (2.05 ± 0.10 kb/min) very similar to other trypanosomatids, we found that the majority of DNA molecules replicated more slowly, with a frequency distribution approximately 1 kb/min. This frequency distribution analysis provides more information about the replication profile of this organism.
The Sub‐Chromosomic Macronuclear Pheromone Genes of the Ciliate Euplotes raikovi: Comparative Structural Analysis and Insights into the Mechanism of Expression
Authors: Ricci Francesca , Candelori Annalisa , Brandi Anna , Alimenti Claudio , Luporini Pierangelo , Vallesi Adriana 
Published: August 2018

AbstractIn Euplotes raikovi, we have determined the full‐length sequences of a family of macronuclear genes that are the transcriptionally active versions of codominant alleles inherited at the mating‐type (mat) locus of the micronuclear genome, and encode cell type‐distinctive signaling pheromones. These genes include a 225–231‐bp coding region flanked by a conserved 544‐bp 5′‐leader region and a more variable 3′‐trailer region. Two transcription initiation start sites and two polyadenylation sites associated with nonconventional signals cooperate with a splicing phenomenon of a 326‐bp intron residing in the 5′‐leader region in the generation of multiple transcripts from the same gene. In two of them, the synthesis of functional products depends on the reassignment to a sense codon, or readthrough of a strictly conserved leaky UAG stop codon. That this reassignment may take place is suggested by the position this codon occupies in the transcripts, close to the transcript extremity and far from the poly(A) tail. In such a case, one product is a 69‐amino acid protein in search of function and the second product is a 126‐amino acid protein that represents a membrane‐bound pheromone isoform candidate to function as a cell type‐specific binding site (receptor) of the soluble pheromones.
In Vitro Cellular Division of Trypanosoma abeli Reveals Two Pathways for Organelle Replication
Authors: Borges Alyssa R. , Toledo Daniel A. , Fermino Bruno R. , de Oliveira José Carlos , Silber Ariel Mariano , Elias Maria Carolina , D'Avila Heloisa , Scopel Kézia K. G. 
Published: August 2018

AbstractSince the observation of the great pleomorphism of fish trypanosomes, in vitro culture has become an important tool to support taxonomic studies investigating the biology of cultured parasites, such as their structure, growth dynamics, and cellular cycle. Relative to their biology, ex vivo and in vitro studies have shown that these parasites, during the multiplication process, duplicate and segregate the kinetoplast before nucleus replication and division. However, the inverse sequence (the nucleus divides before the kinetoplast) has only been documented for a species of marine fish trypanosomes on a single occasion. Now, this previously rare event was observed in Trypanosoma abeli, a freshwater fish trypanosome. Specifically, from 376 cultured parasites in the multiplication process, we determined the sequence of organelle division for 111 forms; 39% exhibited nucleus duplication prior to kinetoplast replication. Thus, our results suggest that nucleus division before the kinetoplast may not represent an accidental or erroneous event occurring in the main pathway of parasite reproduction, but instead could be a species‐specific process of cell biology in trypanosomes, such as previously noticed for Leishmania. This “alternative” pathway for organelle replication is a new field to be explored concerning the biology of marine and freshwater fish trypanosomes.
Misdiagnosis of Chikungunya Virus Infection: Comparison of Old and Younger Adults
Authors: Godaert Lidvine , Bartholet Seendy , Gazeuse Yannick , Brouste Yannick , Najioullah Fatiha , Kanagaratnam Lukshe , Césaire Raymond , Fanon Jean‐Luc , Dramé Moustapha 
Published: August 2018

ObjectivesTo assess the frequency of diagnostic errors in older adults presenting to the emergency department (ED) with symptoms suggestive of Chikungunya virus infection (CVI) and to compare the rates of misdiagnosis of older and younger adults.DesignCross‐sectional study performed in the University Hospitals of Martinique from retrospective cases.SettingEmergency department.ParticipantsIndividuals aged 65 and older who attended the ED and underwent reverse transcription polymerase chain reaction (RT‐PCR) testing for CVI between January and December 2014 (n=333, mean age 80±8) were considered eligible and were compared with a randomly selected sample of younger adults (< 65) (n=143, mean age 45±13).MeasurementsMisdiagnosis rates.ResultsThe rate of misdiagnosis of CVI in the ED was 30.6% in individuals aged 65 and older and 6.3% in those younger than 65 (p<.001). The overdiagnosis rate was 9.0% in individuals aged 65 and older and 3.5% in those younger than 65 (p=.04). The underdiagnosis rate was significantly higher (p<.001) in individuals aged 65 and older (21.6%) than in those younger than 65 (2.8%).ConclusionMisdiagnosis of CVI during an epidemic is statistically more frequent in older than younger adults because clinical presentation is often atypical in older adults. Specific diagnostic tools for older adults and better awareness of ED physicians of different presentations in different age groups could help to reduce the rate of misdiagnosis of CVI in the ED.
Interactive Visualization and Industrial Ecology: Applications, Challenges, and Opportunities
Authors: Font Vivanco David , Hoekman Paul , Fishman Tomer , Pauliuk Stefan , Niccolson Sidney , Davis Chris , Makov Tamar , Hertwich Edgar 
Published: August 2018

SummaryThe emergence of increasingly complex data in industrial ecology (IE) has caused scholarly interest in interactive visualization (IV). IV allows users to interact with data, aiding in processing and interpreting complex datasets, processes, and simulations. Consequently, IV can help IE practitioners communicate the complexities of their methods and results, shed light on the underlying research assumptions, and enable more transparent monitoring of data quality and error. This can significantly increase the reach and impact of research, promote transparency, reproducibility, and open science, as well as improve the clarity and presentation of IE research. A review of current IV applications reveals that, while data exploration has received some attention among IE practitioners, IV applications in scientific communication are clearly lacking. With the help of a working example, we explore the value of IV, discuss its operationalization, and highlight challenges that the IE community must face during IV uptake. Such challenges include technical and knowledge limitations, limits on user interaction, and implementation strategies. With these challenges in mind, we outline key aspects needed to lift the IE field to the forefront of scientific communication in the coming years. Among these, we draft the basic principles of a “Hub for Interactive Visualization in Industrial Ecology” (HIVE), a point of encounter where IE practitioners could find an array of data visualization tools that are geared toward IE datasets. IV is here to stay, and its inceptive stage presents many opportunities to IE practitioners to shape its operationalization and benefit from early adoption.