bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Vibrations on Thermal Performance of Miniature Loop Heat Pipe for Avionics Cooling: An Experimental Analysis
Authors: Kumar Prem , Khandekar Sameer , Maydanik Yuri F. , Bhattacharya Bishakh 
Published: September 2019

Abstract
A loop heat pipe (LHP) is an efficient passive, two-phase heat transfer device which can transport heat up to large distances (over ∼ 5 m) even in the anti-gravity mode. It is necessary to miniaturize the LHPs to make them suitable for space-constrained avionics applications. However, before incorporating these devices under high-vibrational environmental conditions such as those encountered in avionics applications, it is imperative to study their thermal performance under such loads. With the aim of understanding the effect of acceleration and frequency of imposed vibration on thermal performance of miniature LHP (mLHP), a contextual experimental study has been reported here using an ammonia charged mLHP (8 mm evaporator diameter; titanium wick) in the horizontal orientation for two cases: (a) without vibration and (b) with the transverse and longitudinal harmonic vibrations (1–4g, frequencies 15–45 Hz, and sine sweep 15–45 Hz in 1 s). With start-up loads between 5 W and 8 W, the LHP can transfer heat load of about 120 W at safe evaporation temperature of 70 °C. Results show that for the transverse vibration, acceleration rate and frequency of imposed vibrations do not affect the thermal performance of mLHP. For the longitudinal vibration, the device performance gets noticeably enhanced with increased acceleration. The decisive role of heat leak (from evaporator to the compensation chamber (CC)) with imposed vibrations is clearly observed, and its link to the internal fluid distribution can be discerned from data trends.
Reconfiguration of a 3-(rR)PS Metamorphic Parallel Mechanism Based on Complete Workspace and Operation Mode Analysis
Authors: Nurahmi Latifah , Gan Dongming 
Published: September 2019

Abstract
This paper focuses on the reconfiguration of a 3-(rR)PS metamorphic parallel mechanism based on complete workspace and operation mode analysis. The mechanism consists of three (rR)PS legs, and each (rR) joint is composed of two perpendicular revolute joints. One of the (rR) joint axes can be reconfigured continuously, which allows the mechanism to exhibit three distinct configurations. Initially, the constraint equations are derived by using algebraic geometry approach, and the primary decomposition is computed for the three configurations. It reveals that the 3-(rR)PS metamorphic parallel mechanism can exhibit one up to two operation modes among three configurations. When the second axes of the three (rR) joints intersect at a finite point and not coplanar, the 3-(rR)PS metamorphic parallel mechanism has only one operation mode. If the second axes of the three (rR) joints are coplanar, the 3-(rR)PS metamorphic parallel mechanism has two operation modes. It is shown that both operation modes have the same motion type, namely, 1T2R motion. However, to realize the same trajectories in both operation modes, the moving platform will have different orientations. Hence, the orientation workspaces of both operation modes are characterized and the axodes are used to compare the instantaneous motion of the moving platform when passing through the same trajectories. Based on these results, an identification approach is introduced to identify which operation mode a given mechanism pose belongs to and this provides a useful method for trajectory planning.
Vibratory Response Characteristics of High-Frequency Shape Memory Alloy Actuators
Authors: Kennedy Scott , Price Morgan , Zabala Michael , Perkins Edmon 
Published: September 2019

Abstract
This paper presents a shape memory alloy actuator design using a bimorph structure capable of high-speed actuation and low power consumption. Two active layers of shape memory alloy wires are separated by a passive layer of thermoplastic polyurethane. This structure results in a bending actuator when current is alternated between the two active shape memory alloy layers. Actuators of lengths 20, 25, 30, 35, and 40 mm were tested at peak current input of 110, 120, 130, and 140 mA. The 40-mm actuator was shown to have a natural frequency of 11.4 Hz with a bending displacement of 26.4 mm perpendicular to the neutral position and a power input of 0.78 W (140 mA peak current input). A relationship between the input current and the resulting vibratory characteristics was found. As the current increases, the natural frequency decreases and the damping ratio increases. The experimental results are compared with a finite element method (FEM) vibration analysis and an Euler–Bernoulli cantilever beam equations.
Integrated prevention and management of non-communicable diseases, including musculoskeletal health: a systematic policy analysis among OECD countries
Authors: Briggs Andrew M , Persaud Jennifer G , Deverell Marie L , Bunzli Samantha , Tampin Brigitte , Sumi Yuka , Amundsen Olav , Houlding Elizabeth MG , Cardone Anontella , Hugosdottir Thora , Rogers Sophia , Pozsgai Miklós , Slater Helen 
Published: September 2019

IntroductionDevelopment and implementation of appropriate health policy is essential to address the rising global burden of non-communicable diseases (NCDs). The aim of this study was to evaluate existing health policies for integrated prevention/management of NCDs among Member States of the Organisation for Economic Co-operation and Development (OECD). We sought to describe policies’ aims and strategies to achieve those aims, and evaluate extent of integration of musculoskeletal conditions as a leading cause of global morbidity.MethodsPolicies submitted by OECD Member States in response to a World Health Organization (WHO) NCD Capacity Survey were extracted from the WHO document clearing-house and analysed following a standard protocol. Policies were eligible for inclusion when they described an integrated approach to prevention/management of NCDs. Internal validity was evaluated using a standard instrument (sum score: 0–14; higher scores indicate better quality). Quantitative data were expressed as frequencies, while text data were content-analysed and meta-synthesised using standardised methods.ResultsAfter removal of duplicates and screening, 44 policies from 30 OECD Member States were included. Three key themes emerged to describe the general aims of included policies: system strengthening approaches; improved service delivery; and better population health. Whereas the policies of most countries covered cancer (83.3%), cardiovascular disease (76.6%), diabetes/endocrine disorders (76.6%), respiratory conditions (63.3%) and mental health conditions (63.3%), only half the countries included musculoskeletal health and pain (50.0%) as explicit foci. General strategies were outlined in 42 (95.5%) policies—all were relevant to musculoskeletal health in 12 policies, some relevant in 27 policies and none relevant in three policies. Three key themes described the strategies: general principles for people-centred NCD prevention/management; enhanced service delivery; and system strengthening approaches. Internal validity sum scores ranged from 0 to 13; mean: 7.6 (95% CI 6.5 to 8.7).ConclusionRelative to other NCDs, musculoskeletal health did not feature as prominently, although many general prevention/management strategies were relevant to musculoskeletal health improvement.
‘Communities are attempting to tackle the crisis’: a scoping review on community plans to prevent and reduce opioid-related harms
Authors: Leece Pamela , Khorasheh Triti , Paul Nimitha , Keller-Olaman Sue , Massarella Susan , Caldwell Jayne , Parkinson Michael , Strike Carol , Taha Sheena , Penney Greg , Henderson Rita , Manson Heather 
Published: September 2019

ObjectivesWe sought to understand the implementation of multifaceted community plans to address opioid-related harms.DesignOur scoping review examined the extent of the literature on community plans to prevent and reduce opioid-related harms, characterise the key components, and identify gaps.Data sourcesWe searched MEDLINE, Embase, PsycINFO, CINHAL, SocINDEX and Academic Search Primer, and three search engines for English language peer-reviewed and grey literature from the past 10 years.Eligibility criteriaEligible records addressed opioid-related harms or overdose, used two or more intervention approaches (eg, prevention, treatment, harm reduction, enforcement and justice), involved two or more partners and occurred in an Organisation for Economic Co-operation and Development country.Data extraction and synthesisQualitative thematic and quantitative analysis was conducted on the charted data. Stakeholders were engaged through fourteen interviews, three focus groups and one workshop.ResultsWe identified 108 records that described 100 community plans in Canada and the USA; four had been evaluated. Most plans were provincially or state funded, led by public health and involved an average of seven partners. Commonly, plans used individual training to implement interventions. Actions focused on treatment and harm reduction, largely to increase access to addiction services and naloxone. Among specific groups, people in conflict with the law were addressed most frequently. Community plans typically engaged the public through in-person forums. Stakeholders identified three key implications to our findings: addressing equity and stigma-related barriers towards people with lived experience of substance use; improving data collection to facilitate evaluation; and enhancing community partnerships by involving people with lived experience of substance use.ConclusionCurrent understanding of the implementation and context of community opioid-related plans demonstrates a need for evaluation to advance the evidence base. Partnership with people who have lived experience of substance use is underdeveloped and may strengthen responsive public health decision making.
Perspective of asylum-seeking caregivers on the quality of care provided by a Swiss paediatric hospital: a qualitative study
Authors: Brandenberger Julia , Sontag Katrin , Duchêne-Lacroix Cédric , Jaeger Fabienne Nicole , Peterhans Bernadette , Ritz Nicole 
Published: September 2019

ObjectivesThis study investigated the perspective of asylum-seeking caregivers on the quality of healthcare delivered to their children in a qualitative in-depth interview study. The health of asylum-seeking children is of key interest for healthcare providers, yet knowledge of the perspective of asylum-seeking caregivers when accessing healthcare is limited.SettingThe study took place in a paediatric tertiary care hospital in Basel, Switzerland.ParticipantsInterviews were done with 13 asylum-seeking caregivers who had presented with their children at the paediatric tertiary care hospital. Nine female and four male caregivers from Tibet, Eritrea, Afghanistan, Syria, Iraq, Albania and Macedonia were included. A diverse sample was chosen regarding cultural and social background, years of residence in Switzerland and reasons for seeking care. A previously developed and pilot-tested interview guide was used for semistructured in-depth interviews between 36 and 92 min in duration. Data analysis and reporting was done according to Consolidated Criteria for Reporting Qualitative Research. The number of interviews was determined by saturation of data.ResultsThe interviewees described a mismatch of personal competencies and external challenges. Communication barriers and unfamiliarity with new health concepts were reported as challenges. These were aggravated by isolation and concerns about their child’s health. The following factors were reported to strongly contribute to satisfaction of healthcare delivery: a respectful and trusting caregiver–provider relationship, the presence of interpreters and immediate availability of treatment.ConclusionsA mismatch of personal competencies and external challenges importantly influences the caregiver–provider relationship. To overcome this mismatch establishment of confidence was identified as a key factor. This can be achieved by availability of interpreter services, sufficient consultation time and transcultural trainings for healthcare workers. Coordination between the family, the government’s asylum system and the medical system is required to facilitate this process.
Inequalities and stillbirth in the UK: a meta-narrative review
Authors: Kingdon Carol , Roberts Devender , Turner Mark A , Storey Claire , Crossland Nicola , Finlayson Kenneth William , Downe Soo 
Published: September 2019

ObjectiveTo review what is known about the relationship between stillbirth and inequalities from different disciplinary perspectives to inform stillbirth prevention strategies.DesignSystematic review using the meta-narrative method.SettingStudies undertaken in the UK.Data sourcesScoping phase: experts in field, exploratory electronic searches and handsearching. Systematic searches phase: Nine databases with no geographical or date restrictions. Non-English language studies were excluded.Study selectionAny investigation of stillbirth and inequalities with a UK component.Data extraction and synthesisThree authors extracted data and assessed study quality. Data were summarised, tabulated and presented graphically before synthesis of the unfolding storyline by research tradition; and then of the commonalities, differences and interplays between narratives into resultant summary meta-themes.ResultsFifty-four sources from nine distinctive research traditions were included. The evidence of associations between social inequalities and stillbirth spanned 70 years. Across research traditions, there was recurrent evidence of the social gradient remaining constant or increasing, fuelling repeated calls for action (meta-theme 1: something must be done). There was less evidence of an effective response to these calls. Data pertaining to socioeconomic, area and ethnic disparities were routinely collected, but not consistently recorded, monitored or reported in relation to stillbirth (meta-theme 2: problems of precision). Many studies stressed the interplay of socioeconomic status, deprivation or ethnicity with aggregated factors including heritable, structural, environmental and lifestyle factors (meta-theme 3: moving from associations towards intersectionality and intervention(s)). No intervention studies were identified.ConclusionResearch investigating inequalities and stillbirth in the UK is underdeveloped. This is despite repeated evidence of an association between stillbirth risk and poverty, and stillbirth risk, poverty and ethnicity. A specific research forum is required to lead the development of research and policy in this area, which can harness the multiple relevant research perspectives and address the intersections between different policy areas.PROSPERO registration numberCRD42017079228.
Hospital-level evaluation of the effect of a national quality improvement programme: time-series analysis of registry data
Authors: Stephens Timothy J , Peden Carol J , Haines Ryan , Grocott Mike P W , Murray Dave , Cromwell David , Johnston Carolyn , Hare Sarah , Lourtie Jose , Drake Sharon , Martin Graham P , Pearse Rupert M 
Published: September 2019

Background and objectivesA clinical trial in 93 National Health Service hospitals evaluated a quality improvement programme for emergency abdominal surgery, designed to improve mortality by improving the patient care pathway. Large variation was observed in implementation approaches, and the main trial result showed no mortality reduction. Our objective therefore was to evaluate whether trial participation led to care pathway implementation and to study the relationship between care pathway implementation and use of six recommended implementation strategies.MethodsWe performed a hospital-level time-series analysis using data from the Enhanced Peri-Operative Care for High-risk patients trial. Care pathway implementation was defined as achievement of >80% median reliability in 10 measured care processes. Mean monthly process performance was plotted on run charts. Process improvement was defined as an observed run chart signal, using probability-based ‘shift’ and ‘runs’ rules. A new median performance level was calculated after an observed signal.ResultsOf 93 participating hospitals, 80 provided sufficient data for analysis, generating 800 process measure charts from 20 305 patient admissions over 27 months. No hospital reliably implemented all 10 processes. Overall, only 279 of the 800 processes were improved (3 (2–5) per hospital) and 14/80 hospitals improved more than six processes. Mortality risk documented (57/80 (71%)), lactate measurement (42/80 (53%)) and cardiac output guided fluid therapy (32/80 (40%)) were most frequently improved. Consultant-led decision making (14/80 (18%)), consultant review before surgery (17/80 (21%)) and time to surgery (14/80 (18%)) were least frequently improved. In hospitals using ≥5 implementation strategies, 9/30 (30%) hospitals improved ≥6 care processes compared with 0/11 hospitals using ≤2 implementation strategies.ConclusionOnly a small number of hospitals improved more than half of the measured care processes, more often when at least five of six implementation strategies were used. In a longer term project, this understanding may have allowed us to adapt the intervention to be effective in more hospitals.
Neurophysiological responses and adaptation following repeated bouts of maximal lengthening contractions in young and older adults
Authors: Škarabot Jakob , Ansdell Paul , Temesi John , Howatson Glyn , Goodall Stuart , Durbaba Rade 
Published: September 2019

A bout of maximal lengthening contractions is known to produce muscle damage, but confers protection against subsequent damaging bouts, with both tending to be lower in older adults. Neural factors contribute to this adaptation, but the role of the corticospinal pathway remains unclear. Twelve young (27 ± 5 yr) and 11 older adults (66 ± 4 yr) performed two bouts of 60 maximal lengthening dorsiflexions 2 weeks apart. Neuromuscular responses were measured preexercise, immediately postexercise, and at 24 and 72 h following both bouts. The initial bout resulted in prolonged reductions in maximal voluntary torque (MVC; immediately postexercise onward, P < 0.001) and increased creatine kinase (from 24 h onward, P = 0.001), with both responses being attenuated following the second bout ( P < 0.015), demonstrating adaptation. Smaller reductions in MVC following both bouts occurred in older adults ( P = 0.005). Intracortical facilitation showed no changes ( P ≥ 0.245). Motor-evoked potentials increased 24 and 72 h postexercise in young ( P ≤ 0.038). Torque variability ( P ≤ 0.041) and H-reflex size ( P = 0.024) increased, while short-interval intracortical inhibition (SICI; P = 0.019) and the silent period duration (SP) decreased ( P = 0.001) in both groups immediately postexercise. The SP decrease was smaller following the second bout ( P = 0.021), and there was an association between the change in SICI and reduction in MVC 24 h postexercise in young adults ( R = −0.47, P = 0.036). Changes in neurophysiological responses were mostly limited to immediately postexercise, suggesting a modest role in adaptation. In young adults, neural inhibitory changes are linked to the extent of MVC reduction, possibly mediated by the muscle damage–related afferent feedback. Older adults incurred less muscle damage, which has implications for exercise prescription. NEW & NOTEWORTHY This is the first study to have collectively assessed the role of corticospinal, spinal, and intracortical activity in muscle damage attenuation following repeated bouts of exercise in young and older adults. Lower levels of muscle damage in older adults are not related to their neurophysiological responses. Neural inhibition transiently changed, which might be related to the extent of muscle damage; however, the role of processes along the corticospinal pathway in the adaptive response is limited.
Protective Effects of Oridonin on Acute Liver Injury via Impeding Posttranslational Modifications of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) in the Toll-Like Receptor 4 (TLR4) Signaling Pathway
Authors: Shi Min , Deng Yilin , Yu Heguo , Xu Ling , Shi Cuicui , Chen Jiong , Li Guangming , Du Yiqi , Wang Yu-gang 
Published: September 2019

Objective. Recent researches have demonstrated that inflammation-related diseases are effectively regulated by posttranslational modifications (PTMs) including phosphorylation and acetylation. Our previous study found a new acetyltransferase inhibitor, oridonin, which had a protective effect on acute liver injury (ALI). In the present study, we further investigated its protective mechanism against D-galactosamine (D-Gal) combined with lipopolysaccharide- (LPS-) induced ALI in mice. Methods. Intraperitoneal injections of LPS (40 μg/mouse)/D-Gal (5 mg/mouse) were given to the mice, and the experimental group was pretreated with intraperitoneal injection of oridonin (0.2 mg/mouse). To elucidate the protective mechanism of oridonin, we collected liver specimens and used RNA-sequencing (RNA-Seq) analysis. We focused on the genes that were upregulated by LPS/D-Gal and downregulated after pretreatment with oridonin. The downregulated genes examined by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were further verified by real-time polymerase chain reaction (PCR) and western blot. Results. GO analysis showed that genes that were downregulated after pretreatment with oridonin were extremely concentrated in immune response, chemotaxis, and inflammatory response. Real-time PCR confirmed that the expression of these genes was upregulated by LPS/D-Gal induction and reduced after treatment with oridonin, which was consistent with RNA-Seq results. KEGG pathway analysis showed a significantly enriched downregulated gene that was present in the Toll-like receptor (TLR) 4 signaling cascade. Our results manifested that phosphorylation levels of upstream signaling molecules in the TLR4 signaling cascade, including extracellular signal-regulated kinase (ERK), P38, and IκB, were significantly inhibited by oridonin. Furthermore, LPS/D-Gal stimulation triggered posttranslational modifications of related gene loci in the TLR4 signaling pathway, including phosphorylation of IL-1 receptor-associated kinase 4 (IRAK4 T345/S346) and acetylation of IRAK4 (K34). However, after treatment with oridonin, the modification pattern of IRAK4 expression stimulated by LPS/D-Gal was suggestively attenuated. Conclusion. Our study revealed that the protective effects of oridonin on LPS/D-Gal-induced ALI mediated by inhibition of the PTMs of IRAK4, including phosphorylation of T345/S346 and acetylation of K34.
Perspectives for Consideration in the Development of Microbial Cell Reference Materials
Authors: Allen-Vercoe Emma , Carmical Joseph Russell , Forry Samuel P. , Gail Mitchell H. , Sinha Rashmi 
Published: September 2019

Abstract
Microbiome measurement and analyses benefit greatly from incorporation of reference materials as controls. However, there are many points to consider in defining an ideal whole-cell reference material standard. Such a standard would embody all the diversity and measurement challenges present in real samples, would be completely characterized to provide “ground truth” data, and would be inexpensive and widely available. This ideal is, unfortunately, not readily attainable because of the diverse nature of different sequencing projects. Some applications may benefit most from highly complex reference materials, while others will value characterization or low expense more highly. The selection of appropriate microbial whole-cell reference materials to benchmark and validate microbial measurements should be considered carefully and may vary among specific applications. In this article, we describe a perspective on the development of whole-cell microbial reference materials for use in metagenomics analyses.