bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left atrial rupture during on-pump beating coronary artery bypass grafting
Authors: Hidaka Hideaki , Sadanaga Tatsuaki , Hirota Takafumi , Horibe Tatsuya , Takaki Jun , Nishigawa Kosaku , Yoshinaga Takashi , Fukui Toshihiro 
Published: November 2024

Abstract
Background
On-pump beating coronary artery bypass grafting (CABG) is a procedure that uses cardiopulmonary bypass to maintain circulation and it is a useful technique for CABG in patients with severely impaired cardiac function. Here, we report a case of left atrial rupture that occurred during CABG. Reports of left atrial injury are rare, and there have been no previous reports of such cases associated with on-pump beating CABG.

Case presentation
An 80-year-old man with a history of myocardial infarction was admitted to another hospital for acute heart failure. Coronary angiography revealed triple-vessel disease, and echocardiography showed reduced left ventricular function and moderate mitral regurgitation. He was transferred to our hospital for coronary artery bypass grafting and the operation was scheduled. Surgery was started with the intention of off-pump CABG, but due to circulatory instability, the patient was converted to on-pump beating CABG. While the heart was being dislocated and anastomosis was being performed, sudden bleeding from the left atrium occurred. To achieve hemostasis, we needed to arrest the patient's heart. A 5-cm laceration along the posterior mitral annulus was found in the left atrium and repaired with a bovine pericardial patch. Mitral annuloplasty with a flexible ring was performed simultaneously. He recovered uneventfully.

Conclusions
The left atrial rupture during on-pump beating coronary artery bypass grafting is extremely rare. The wall of the atrium is thought to have been damaged by the stress applied during the displacement of the heart and the impact of the enlarged mitral regurgitant jet. Repair under cardiac arrest is necessary, and in some cases, mitral annuloplasty may be additionally required.
Corrected partial anomalous pulmonary vein connection associated with lung resection: a case report
Authors: Nakata Kosuke , Takaki Jun , Fukui Toshihiro 
Published: November 2024

Abstract
Introduction
Partial anomalous pulmonary venous connection (PAPVC) is a potential cause of right-sided heart failure. Notably, a risk of sudden circulatory failure exists during lung surgery. Only a few reports of PAPVC complicated by lung cancer requiring lobectomy exist. Here, we report a case of left lower lung lobectomy complicated by an anomalous connection of the left upper pulmonary vein requiring revascularization.

Case presentation
A 66-year-old man was found with an abnormal mass shadow in the left lower lung field on chest radiography. Bronchoscopy revealed lung adenocarcinoma. Preoperative contrast-enhanced computed tomography showed that the left upper pulmonary vein did not perfuse the left atrium but was connected to the left brachiocephalic vein. Preoperative transthoracic echocardiography revealed right atrial and ventricular enlargement. The clinical diagnosis was stage IB (T2aN0M0). We decided to perform a left lower lobectomy and correct the PAPVC to maintain oxygenation after the lobectomy. The PAPVC was ligated, and the stump of the left upper pulmonary vein was anastomosed to the left atrial appendage without cardiopulmonary bypass. Postoperative contrast-enhanced computed tomography revealed intact reconstructed vessels. Postoperative transthoracic echocardiography showed no right ventricular overload. The patient’s postoperative clinical course following the surgical procedure was uneventful. Furthermore, the patient was followed up without any complications.

Conclusions
This rare case of successful surgical correction can inform clinicians of similar cases.
Soil properties drive nitrous oxide accumulation patterns by shaping denitrifying bacteriomes
Authors: Bano Saira , Wu Qiaoyu , Yu Siyu , Wang Xinhui , Zhang Xiaojun 
Published: November 2024

AbstractIn agroecosystems, nitrous oxide (N₂O) emissions are influenced by both microbiome composition and soil properties, yet the relative importance of these factors in determining differential N₂O emissions remains unclear. This study investigates the impacts of these factors on N₂O emissions using two primary agricultural soils from northern China: fluvo-aquic soil (FS) from the North China Plain and black soil (BS) from Northeast China, which exhibit significant differences in physicochemical properties. In non-sterilized controls (NSC), we observed distinct denitrifying bacterial phenotypes between FS and BS, with BS exhibiting significantly higher N₂O emissions. Cross-inoculation experiments were conducted by introducing extracted microbiomes into sterile recipient soils of both types to disentangle the relative contributions of soil properties and microbiomes on N₂O emission potential. The results showed recipient-soil-dependent gas kinetics, with significantly higher N₂O/(N₂O + N₂) ratios in BS compared to FS, regardless of the inoculum type. Metagenomic analysis further revealed significant shifts in denitrification genes and microbial diversity of the inoculated bacteriomes influenced by the recipient soil. The higher ratios of nirS/nosZ in FS and nirK/nosZ in BS indicated that the recipient soil dictates the formation of different denitrifying guilds. Specifically, the BS environment fosters nirK-based denitrifiers like Rhodanobacter, contributing to higher N₂O accumulation, while FS supports a diverse array of denitrifiers, including Pseudomonas and Stutzerimonas, associated with complete denitrification and lower N₂O emissions. This study underscores the critical role of soil properties in shaping microbial community dynamics and greenhouse gas emissions. These findings highlight the importance of considering soil physicochemical properties in managing agricultural practices to mitigate N₂O emissions.
Local QSAR based on quantum chemistry calculations for the stability of nitrenium ions to reduce false positive outcomes from standard QSAR systems for the mutagenicity of primary aromatic amines
Authors: Muto Shigeharu , Furuhama Ayako , Yamamoto Mika , Otagiri Yasuteru , Koyama Naoki , Hitaoka Seiji , Nagato Yusuke , Ouchi Hirofumi , Ogawa Masahiro , Shikano Kisako , Yamada Katsuya , Ono Satoshi , Hoki Minami , Ishizuka Fumiya , Hagio Soichiro , Takeshita Chiaki , Omori Hisayoshi , Hashimoto Kiyohiro , Chikura Satsuki , Honma Masamitsu , Sugiyama Kei-ichi , Mishima Masayuki 
Published: November 2024

Abstract
Background
Primary aromatic amines (PAAs) present significant challenges in the prediction of mutagenicity using current standard quantitative structure activity relationship (QSAR) systems, which are knowledge-based and statistics-based, because of their low positive prediction values (PPVs). Previous studies have suggested that PAAs are metabolized into genotoxic nitrenium ions. Moreover, ddE, a relative-energy based index derived from quantum chemistry calculations that measures the stability nitrenium ions, has been correlated with mutagenicity. This study aims to further examine the ability of the ddE-based approach in improving QSAR mutagenicity predictions for PAAs and to develop a refined method to decrease false positive predictions.

Results
Information on 1,177 PAAs was collected, of which 420 were from public databases and 757 were from in-house databases across 16 laboratories. The total dataset included 465 Ames test-positive and 712 test-negative chemicals. For internal PAAs, detailed Ames test data were scrutinized and final decisions were made using common evaluation criteria. In this study, ddE calculations were performed using a convenient and consistent protocol. An optimal ddE cutoff value of -5 kcal/mol, combined with a molecular weight ≤ 500 and ortho substitution groups yielded well-balanced prediction scores: sensitivity of 72.0%, specificity of 75.9%, PPV of 65.6%, negative predictive value of 80.9% and a balanced accuracy of 74.0%. The PPV of the ddE-based approach was greatly reduced by the presence of two ortho substituent groups of ethyl or larger, as because almost all of them were negative in the Ames test regardless of their ddE values, probably due to steric hindrance affecting interactions between the PAA and metabolic enzymes. The great majority of the PAAs whose molecular weights were greater than 500 were also negative in Ames test, despite ddE predictions indicating positive mutagenicity.

Conclusions
This study proposes a refined approach to enhance the accuracy of QSAR mutagenicity predictions for PAAs by minimizing false positives. This integrative approach incorporating molecular weight, ortho substitution patterns, and ddE values, substantially can provide a more reliable basis for evaluating the genotoxic potential of PAAs.
Nanocochleate-based delivery of quercetin with enhanced therapeutic potential: formulation, cytotoxicity and pharmacokinetics study
Authors: Kapare Harshad S. , Patil Nagesh , Bhosale Mayuri , Kulkarni Deepak , Bhole Ritesh 
Published: November 2024

Abstract
Background
Quercetin has well-proven anticancer potential through various mechanisms, but its applications in drug delivery are limited due to poor biopharmaceutical properties. The present study was aimed to formulate quercetin nanocochleates (QNC) in order to overcome these limitations. QNC formulation was fabricated by a trapping method, optimized and evaluated for various formulation aspects, in vitro cytotoxicity and pharmacokinetic parameters.

Result
Developed nanocochleates possess particle size and encapsulation efficiency of 205.6 ± 2.55 nm and 76.36 ± 0.88%, respectively. In vitro cytotoxicity study performed using MCF-7 cell lines revealed the comparative efficiency of QNC over pure quercetin. Total growth inhibition concentration (TGI) for pure quercetin was 96.73 μg/ml, while for QNC it was 83.29 μg/ml. Pharmacokinetic study results showed improvement in Cmax and AUC after QNC formulation with increased Tmax showing sustained release.

Conclusion
Overall, the developed QNC formulation markedly improved cytotoxic potential and biopharmaceutical aspects.
Identification of Individuals With Hereditary Cancer Risk Through Multiple Data Sources: A Population-Based Method Using the GARDE Platform and The Utah Population Database
Authors: Del Fiol Guilherme , Madsen Michael J. , Bradshaw Richard L. , Newman Michael G. , Kaphingst Kimberly A. , Tavtigian Sean V. , Camp Nicola J. 
Published: November 2024

PURPOSE
The GARDE platform uses family history reported in the electronic health record (EHR) to systematically identify eligible patients for genetic testing for hereditary cancer syndromes. The goal of this study was to evaluate the change in effectiveness of GARDE to identify eligible individuals when more comprehensive family history data are provided, thus quantifying the impact of underdocumentation.

METHODS
A cohort of 133,764 patients at the University of Utah Health was analyzed with GARDE comparing identification rates using EHR data versus EHR plus data from a statewide population database, the Utah Population Database (UPDB).

RESULTS
Compared with EHR alone, EHR + UPDB increased the rate of individuals eligible for genetic testing from 4.1% to 9.2%. In the 44,692 individuals with the most comprehensive family history, eligibility more than quadrupled from 4.6% (EHR alone) to 19.3% (EHR + UPDB). The increase was significant across all demographics, but disparities still remained for historically marginalized minorities (9.2%-13.9% in non-White races compared with 19.7% in White races).

CONCLUSION
Augmenting EHR data with family history data from the UPDB substantially improved the detection of individuals eligible for genetic testing of hereditary cancer syndromes in all subgroups. This underscores the importance of improving methods for acquiring family history, in person or in silico. However, these increases did not ameliorate disparities. Continuous disparities are unlikely to be explained by incomplete family history alone and may also be because susceptibility genes, risk variants, and screening guidelines were discovered and developed largely in White races. Addressing disparities will require intentional data collection of family history in historically marginalized minorities and the promotion of genetic and risk assessment studies in more diverse populations to ensure equity and health care.
Exploring the Correlation between LC–MS Multi-Attribute Method and Conventional Chromatographic Product Quality Assays through Multivariate Data Analysis
Authors: Jiang Tingting , Kwofie Francis , Attanasio Nick , Haas Matthew , Higgins John , Kosanam Hari 
Published: November 2024

Abstract
Biotherapeutics are subject to inherent heterogeneity due to the complex biomanufacturing processes. Numerous analytical techniques have been employed to identify, characterize, and monitor critical quality attributes (CQAs) to ensure product safety, and efficacy. Mass spectrometry (MS)-based multi-attribute method (MAM) has become increasingly popular in biopharmaceutical industry due to its potential to replace multiple traditional analytical methods. However, the correlation between MAM and conventional methods remains to be fully understood. Additionally, the complex analytical workflow and limited throughput of MAM restricts its implementation as a quality control (QC) release assay. Herein, we present a simple, robust, and rapid MAM workflow for monitoring CQAs. Our rapid approach allowed us to create a database from ~700 samples, including site-specific post-translational modifications (PTMs) quantitation results using MAM and data from traditional charge variant and oxidation characterization methods. To gain insights from this database, we employ multivariate data analysis (MVDA) to thoroughly exploit the data. By applying partial least squares regression (PLSR) models, we demonstrate the ability to quantitatively predict charge variants in ion exchange chromatography (IEX) assay and oxidation abundances in hydrophobic-interaction chromatography (HIC) assay using MAM data, highlighting the interconnectivity between MAM and traditional product quality assays. These findings help evaluate the suitability of MAM as a replacement for conventional methods for release, and more importantly, contribute to enhanced process and product understanding.

Graphical Abstract
Genetic and Clinical Characteristics of 185 Japanese Children With 46,XY Differences of Sex Development
Authors: Hayashi Mie , Narumi Satoshi , Sato Takeshi , Amano Naoko , Suwanai Ayuko Suzuki , Haruna Hidenori , Muroya Koji , Adachi Masanori , Asanuma Hiroshi , Ohashi Hirofumi , Ishii Tomohiro , Hasegawa Tomonobu 
Published: November 2024

Abstract

Context
46,XY differences of sex development (DSD) are heterogeneous in etiology. The detailed phenotypes of 46,XY DSD patients with monogenic disorders have not been fully elucidated.

Objectives
To estimate the proportion of monogenic disorders in 46,XY DSD and to characterize the clinical phenotypes of patients with monogenic disorders.

Methods
A total of 185 Japanese patients (178 families) were enrolled. We sequenced 25 genes related to 46,XY DSD and assessed the pathogenicity of the identified sequence variants according to the American College of Medical Genetics and Genomics guidelines, supplemented by in silico and/or in vitro analyses. We analyzed the clinical phenotypes of patients with monogenic disorders, with particular attention to the external or internal genitalia.

Results
We identified 51 patients (47 families) with any monogenic disorders (26%), who possessed pathogenic variants in AR (11%), SRD5A2 (4.5%), NR5A1 (4.0%), SRY (2.8%), WT1 (1.1%), STAR (1.1%), CYP17A1 (0.56%), HSD3B2 (0.56%), or MAP3K1 (0.56%). The proportion of monogenic disorders was significantly higher in subjects with detected Müllerian derivatives (57%) than in those undetected (26%) (P = .029), and in subjects with female-typical genitalia (91%) than in those with ambiguous genitalia (19%) (P &lt; .001).

Conclusion
The proportion of monogenic disorders in Japanese 46,XY DSD patients was approximately 26%. Monogenic disorders were frequent among patients with severe undermasculinization of the external or internal genitalia.
Pharmacokinetics of Methadone in Adult Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
Authors: Salas Wilbaldo E. , Cortinez Luis I. , López Rodrigo A. , Rolle Augusto , Elgueta Francisca , Godoy Cesar O. , Giordano Ady , Contreras Víctor , Anderson Brian J. 
Published: November 2024

BACKGROUND:
Cardiopulmonary bypass (CPB) induces profound physiological changes that may alter the pharmacokinetics of methadone. We aimed to describe the pharmacokinetics of an intravenous bolus of methadone racemate in adult patients undergoing heart surgery with CPB.

METHODS:
We prospectively studied 29 patients aged 45 to 75 years scheduled for cardiac surgery with CPB who received methadone 0.2 mg/kg after anesthesia induction. Arterial blood samples (n = 10) were taken, before, during, and after CPB. Pharmacokinetic analysis was undertaken using nonlinear mixed effects models.

RESULTS:
All patients completed the study. The median [interquartile range] methadone concentrations decreased from 34.8 [23.9–48.2] ng/mL (10 minutes before CPB) to 18.2 [9.9–26] ng/mL after 60 minutes of CPB (P < .001). A 3-compartment model adequately described the observed changes in methadone concentrations. The influence of CPB on methadone pharmacokinetics was best described by hemodilution in a fixed volume of 1.5 L (CPB circuit volume) and by sequestration from the CPB components (CLSEQ = 93.4 L/h, 95%CI 59–124, P < .01). The observed effect of CPB in methadone pharmacokinetics can be compensated by giving a supplementary bolus dose of 0.05 mg/kg at the end of CPB.

CONCLUSIONS:
Our results confirmed a decay in methadone concentrations during CPB, which, in our modeling analysis, was attributed to hemodilution and sequestration within the CPB components.
The Novel and the Ottoman Institution of Slavery: Domesticity and Slave Labor in Namık Kemal's İntibah
Authors: Camoglu Arif 
Published: November 2024

Abstract
This article makes a case for a critical engagement with the Ottoman institution of slavery and slave trade in its globalist rethinking of the rise of the novel. It argues that production of late Ottoman Turkish novelistic writing hinged on a domestic imagination to which the labor of enslaved women was indispensable. Placing Namık Kemal's İntibah in conversation with other novels contemporaneous with it, the article underscores the interlacement between the genre-conscious crafting of novelistic writing in the nineteenth-century Ottoman Empire and the ubiquitous presence of enslaved women in the fictions from the period. As such, it highlights the necessity of reframing the transnational history of the novel by expanding the interrogation of its gendered and racialized economy to hitherto neglected Ottoman contexts of enslavement.
Why Are So Many U.S. Mothers Becoming Their Family's Primary Economic Support?
Authors: Pepin Joanna R. , McErlean Kimberly , Glass Jennifer L. , Raley R. Kelly 
Published: November 2024

Abstract
Although the growing prevalence of primary-earning mothers is well established, this article uses 1996 and 2014 Survey of Income and Program Participation data to show U.S. mothers’ rate of transition to primary-earner status increased by nearly 50% over the observed period. The rate of transition to primary earning predominantly increased among mothers with some college experience and mothers racialized as White, largely catching up to the rate among mothers identifying as Black. A decomposition analysis determined that relationship instability in marital and cohabiting relationships accounts for less than 20% of the increased transition rate, although somewhat more for Hispanic mothers. Roughly 75% of the growth in maternal primary-earning spells was attributed to situations in which the mother's earnings increased in isolation or, for mothers with a partner, often paired with a decrease in the partner's earnings. This latter circumstance was particularly the case for mothers identifying as Black or Asian. Findings show that most of the growth in mothers becoming primary earners from the mid-1990s to the mid-2010s occurred not because mothers experienced more household economic changes (frequency), but because household economic changes often increased mothers’ relative financial contributions (impact). The impact component accounted for the entire increased transition rate across mothers’ educational attainment and racial and ethnic identity.
The New Militancy
Authors: Roy Tania 
Published: November 2024

Abstract
This special section, entitled “Memory Wars,” marks the twentieth anniversary of Cultural Politics and was initiated a few months after Russia's full-scale invasion of Ukraine in February 2022. Taking as a cue the question of a belligerent revision of history, the journal convened a symposium on “memory wars” in collaboration with the Winchester School of Art, University of Southampton, in June 2023. Geopolitical alignments of Europe and the United States around Ukraine have been catalyzed since by the incursion of Hamas fighters into Israel on October 7, 2023, and the campaign of extermination that has been subsequently waged by Israel on the Gaza Strip. The contributions to this special section engage the current, militarized politics of memory through the premise of increasingly authoritarian forms of liberalism—such militant liberalism is consolidated around an essentially epigonal understanding of the world, which combines reified languages of Holocaust memory culture with refurbished binaries of the Cold War. Entries range from the Russia-NATO war in Ukraine (Tarik Cyril Amar in conversation with Tania Roy), through the cultural domain of Germany and the limits of liberal freedoms of speech and artistic expression before and after October 7 (ruangrupa in conversation with Sophie Goltz), to the crisis of Israel-Palestine now (Ayelet Ben-Yishai).
Dragoun, Michal et al. Knižní kultura českého středověku [Czech Book Culture in the Middle Ages]. Vydání první. Dolní Břežany: Scriptorium, 2020. 399 pp. ISBN 978-80-7649-012-3.
Authors: Brozovska Onderkova Jana 
Published: November 2024

The monograph Knižní kultura českého středověku [Czech Book Culture in the Middle Ages] presents in four chapters the history of the manuscript and partially printed books and book culture, especially the area of book painting and book binding in the Czech lands in the Middle Ages until about the end of the 15th century. There is also an additional topic connected with book history, the period of incunabula. The authors of the individual chapters are Michal Dragoun, Jindřich Marek (Institute of Information Studies and Librarianship, Faculty of Arts, Charles University), Kamil Boldan (National Library of the Czech Republic), Milada Studničková (Institute of Art History, Czech Academy of Sciences). It summarizes new knowledge in areas previously summarized in the publications published in the early 1990s, Česká kniha v proměnách staletí [Czech Book through the centuries], compiled by a collective of authors under the leadership of Mirjam Bohatcová, and Josef Krása’s study České iluminované rukopisy 13.–16. století [Czech Illuminated Manuscripts 13th to 16th centuries]. The reviewed book is based on many years of research done by the members of the author’s team and also on partial studies by personalities of Czech and Moravian codicology and library science (e.g., Jiří Hlaváček, Petr Voit, Ladislav Dokoupil, and others).