bluuebunny/crossref_metadata_2025_split huggingface dataset:
Timing of eating across ten European countries – results from the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study
Authors: Huseinovic Ena , Winkvist Anna , Freisling Heinz , Slimani Nadia , Boeing Heiner , Buckland Genevieve , Schwingshackl Lukas , Olsen Anja , Tjønneland Anne , Stepien Magdalena , Boutron-Ruault Marie-Christine , Mancini Francesca , Artaud Fanny , Kühn Tilman , Katzke Verena , Trichopoulou Antonia , Naska Androniki , Orfanos Philippos , Tumino Rosario , Masala Giovanna , Krogh Vittorio , Santucci de Magistris Maria , Ocké Marga C , Brustad Magritt , Jensen Torill Enget , Skeie Guri , Rodríguez-Barranco Miguel , Huerta José María , Ardanaz Eva , Quirós José Ramón , Jakszyn Paula , Sonestedt Emily , Ericson Ulrika , Wennberg Maria , Key Timothy J , Aune Dagfinn , Riboli Elio , Weiderpass Elisabete , Bertéus Forslund Heléne 
Published: October 2018

AbstractObjectiveTo examine timing of eating across ten European countries.DesignCross-sectional analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study using standardized 24 h diet recalls collected during 1995–2000. Eleven predefined food consumption occasions were assessed during the recall interview. We present time of consumption of meals and snacks as well as the later:earlier energy intake ratio, with earlier and later intakes defined as 06.00–14.00 and 15.00–24.00 hours, respectively. Type III tests were used to examine associations of sociodemographic, lifestyle and health variables with timing of energy intake.SettingTen Western European countries.SubjectsIn total, 22 985 women and 13 035 men aged 35–74 years (n36 020).ResultsA south–north gradient was observed for timing of eating, with later consumption of meals and snacks in Mediterranean countries compared with Central and Northern European countries. However, the energy load was reversed, with the later:earlier energy intake ratio ranging from 0·68 (France) to 1·39 (Norway) among women, and from 0·71 (Greece) to 1·35 (the Netherlands) among men. Among women, country, age, education, marital status, smoking, day of recall and season were all independently associated with timing of energy intake (allP<0·05). Among men, the corresponding variables were country, age, education, smoking, physical activity, BMI and day of recall (allP<0·05).ConclusionsWe found pronounced differences in timing of eating across Europe, with later meal timetables but greater energy load earlier during the day in Mediterranean countries compared with Central and Northern European countries.
Fish consumption prior to pregnancy and pregnancy outcomes in the National Birth Defects Prevention Study, 1997–2011
Authors: Benjamin Renata H , Mitchell Laura E , Canfield Mark A , Hoyt Adrienne T , Lai Dejian , Ramadhani Tunu A , Carmichael Suzan L , Case Amy P , Waller D Kim ,   the National Birth Defects Prevention Study
Published: October 2018

AbstractObjectiveTo evaluate the relationships between maternal fish consumption and pregnancy outcomes in a large, population-based sample of women in the USA.DesignWe collected average fish consumption prior to pregnancy using a modified version of the semi-quantitative Willett FFQ. We estimated adjusted OR (aOR) and 95 % CI for associations between different levels of fish consumption and preterm birth (<37 weeks), early preterm birth (<32 and <35 weeks) and small-for-gestational-age infants (SGA; <10th percentile).SettingThe National Birth Defects Prevention Study (NBDPS).SubjectsControl mother–infant pairs with estimated delivery dates between 1997 and 2011 (n 10 919).ResultsNo significant associations were observed between fish consumption and preterm birth or early preterm birth (aOR = 0·7–1·0 and 0·7–0·9, respectively). The odds of having an SGA infant were elevated (aOR = 2·1; 95 % CI 1·2, 3·4) among women with daily fish consumption compared with women consuming fish less than once per month. No associations were observed between other levels of fish consumption and SGA (aOR = 0·8–1·0).ConclusionsHigh intake of fish was associated with twofold higher odds of having an SGA infant, while moderate fish consumption prior to pregnancy was not associated with preterm or SGA. Our study, like many other studies in this area, lacked information regarding preparation methods and the specific types of fish consumed. Future studies should incorporate information on nutrient and contaminant contents, preparation methods and biomarkers to assess these relationships.
Mantle Deformation in the Eastern Himalaya, Burmese Arc and Adjoining Regions
Authors: Saikia Dipankar , Kumar M. Ravi , Singh Arun , Roy Sunil K. , Raju P. Solomon , Lyngdoh A.C 
Published: October 2018

AbstractThis study presents new results of shear wave splitting at 56 broadband stations installed in the Eastern Himalaya, Burmese Arc, and adjoining regions. The fast polarization directions (FPDs) within the Himalaya, Burmese Arc and the foredeep are parallel to the strike of the orogens, suggesting a coherently deformed lithospheric mantle under compression. The FPDs follow the Main Boundary Thrust and the Main Central Thrust in the central segment of the Arunachal Himalaya. Smaller delay times (∼0.7 s) can be best explained by multiple layers of anisotropy, where combined effects of the anisotropic fabric of a coherently deformed lithosphere of the Arunachal Himalaya and plate motion related strain are playing a role. Null measurements in the Siang window may be due to the Indian plate interaction with Eurasia and Burma plates, causing different layers of anisotropy. Another possibility is the coincidence of source polarization direction with the fast axis. In the Bengal Basin, the Nulls could be due to annihilation of frozen anisotropy in the downwelling Indian lithosphere and the APM‐related strain, or a highly heterogeneous mantle affected by the Kereguelen plume magmatism, at ∼116 Ma.
Initiation of Strike‐Slip Faults, Serpentinization, and Methane: The Nootka Fault Zone, the Juan de Fuca‐Explorer Plate Boundary
Authors: Rohr Kristin M. M. , Furlong Kevin P. , Riedel Michael 
Published: October 2018

AbstractThe Nootka fault zone is a ridge‐trench‐trench transform fault that was initiated ~4 Ma when the Explorer ridge became independent of the Juan de Fuca ridge. Multibeam data around the fault zone and a compilation of several seismic reflection surveys provide insight into initiation of strike‐slip faults. Previous interpretations assumed that the two faults seen cutting the seafloor are subparallel to shear between the Explorer and Juan de Fuca plates and formed instantaneously at 4 Ma. Increased data density shows that these faults are subparallel to seafloor magnetic anomalies and appear to have utilized extensional faults formed at the ridge. They are surrounded by numerous buried steeply dipping, small‐offset growth faults; at least some of which are likely still active. Our observations corroborate analogue models of strike‐slip fault initiation that predict formation of Riedel‐like shears within a zone of faulting and that displacement localizes over time. The existence of several long subparallel faults and a very wide zone of faulting has been predicted by models of distributed shear at depth. Along the Nootka fault zone basement has risen by several hundred meters and bright reversed‐polarity reflectors some of which are interpreted to be methane hydrate reflectors are common. Hydration, likely as serpentinization, of the upper mantle could explain both sets of observations: Serpentinization can result in a 30–50% volume expansion and methane is observed in vents driven by this process. Biogenic sources of methane are likely to be present and concentrated by currently active fluid flow in the faulted sediments.
Current and Future Disease Burden From Ambient Ozone Exposure in India
Authors: Conibear Luke , Butt Edward W. , Knote Christoph , Spracklen Dominick V. , Arnold Stephen R. 
Published: October 2018

AbstractLong‐term ambient ozone (O3) exposure is a risk factor for human health. We estimate the source‐specific disease burden associated with long‐term O3 exposure in India at high spatial resolution using updated risk functions from the American Cancer Society Cancer Prevention Study II. We estimate 374,000 (95UI: 140,000–554,000) annual premature mortalities using the updated risk function in India in 2015, 200% larger than estimates using the earlier American Cancer Society Cancer Prevention Study II risk function. We find that land transport emissions dominate the source contribution to this disease burden (35%), followed by emissions from power generation (23%). With no change in emissions by 2050, we estimate 1,126,000 (95UI: 421,000–1,667,000) annual premature mortalities, an increase of 200% relative to 2015 due to population aging and growth increasing the number of people susceptible to air pollution. We find that the International Energy Agency New Policy Scenario provides small changes (+1%) to this increasing disease burden from the demographic transition. Under the International Energy Agency Clean Air Scenario we estimate 791,000 (95UI: 202,000–1,336,000) annual premature mortalities in 2050, avoiding 335,000 annual premature mortalities (45% of the increase) compared to the scenario of no emission change. Our study highlights that critical public health benefits are possible with stringent emission reductions, despite population growth and aging increasing the attributable disease burden from O3 exposure even under such strong emission reductions. The disease burden attributable to ambient fine particulate matter exposure dominates that from ambient O3 exposure in the present day, while in the future, they may be similar in magnitude.
The Longitudinal Variations of Upper Thermospheric Zonal Winds Observed by the CHAMP Satellite at Low and Midlatitudes
Authors: Zhang Kedeng , Wang Wenbin , Wang Hui , Dang Tong , Liu Jing , Wu Qian 
Published: October 2018

AbstractIn this work, we investigate the longitudinal patterns of thermospheric zonal winds (~400 km) and their seasonal and solar activity dependence using CHAllenging Minisatellite Payload cross‐track wind data and Thermosphere Ionosphere Electrodynamics General Circulation Model (TIEGCM) simulations. CHAllenging Minisatellite Payload data show that there are large longitudinal variations in thermospheric zonal winds. These longitudinal variations do not have significant solar activity dependence. In the northern hemisphere at low and middle latitudes, the daytime zonal winds are more westward between −90° and 90° longitudes and more eastward at other longitudes. The nighttime zonal wind direction with pattern is opposite to that in the daytime. In the southern hemisphere at low and middle latitudes, the local time variation of the longitudinal wind structure, including positive and negative peak locations, is almost the reverse of that in the northern hemisphere. Thus, the zonal wind patterns also show great hemispheric asymmetry. In addition, the longitudinal patterns of zonal winds in both hemispheres show seasonal variations. The longitudinal patterns during the June solstice are significantly different from those in other seasons. These observational results are well reproduced in TIEGCM simulations. To elucidate the physical processes responsible for the observed and simulated longitudinal patterns of the zonal winds, the TIEGCM is also run for different geomagnetic field configurations. A comparison between the TIEGCM results shows that geomagnetic field structure is the main cause of the large longitudinal variations of thermospheric zonal winds and their local time, hemispheric asymmetry, and seasonal changes at low and middle latitudes.
Viscous Accretionary Prisms: Viscoelastic Relaxation of the Makran Accretionary Prism Following the 2013 Baluchistan, Pakistan Earthquake
Authors: Peterson Katherine E. , Barnhart William D. , Li Shaoyang 
Published: October 2018

AbstractGeodetic observations of postseismic transients following earthquakes commonly help to inform the rheology of the lower crust and mantle, frictional properties of faults, and the kinematics of deformation across the earthquake cycle. Here we use interferometric synthetic aperture radar time series observations of postseismic deformation following the 2013 Mw 7.7 Baluchistan, Pakistan earthquake to investigate the viscoelastic rheology of the Makran accretionary prism. Using observations that began 15 months after the earthquake and a suite of potential fault geometries, we show that the ongoing deformation transient in the vicinity of the earthquake cannot be explained by afterslip alone. Instead, the gross spatial and temporal characteristics of the transient can be explained by viscoelastic relaxation of a shallow (>6 km) weak zone bounded by the Baluchistan earthquake and the underthrusting Arabian oceanic plate. Our first‐order results show that the viscoelastic lower accretionary prism has a thickness of 8–12 km and exhibits power law (n = 3.5) behavior with viscosities of 1017–1018 Pa·s. These estimated viscosities may be higher if afterslip occurred during the initial period of postseismic deformation not constrained by our observations. The power law rheology suggests that creep processes common at lower crustal and mantle temperatures may be active at comparatively lower temperatures in the Makran. We hypothesize that the weak nature of the Makran accretionary prism is driven by high pore fluid pressures introduced by underplated sediments and/or hydrocarbon development, and we show a mechanically weak accretionary prism may lead to overestimates of plate coupling when linear elasticity is assumed.
Toward a Broadband Parameterization Scheme for Estimating Surface Solar Irradiance: Development and Preliminary Results on MODIS Products
Authors: Huang Guanghui , Liang Shunlin , Lu Ning , Ma Mingguo , Wang Dongdong 
Published: October 2018

AbstractA broadband parameterization scheme for estimating surface solar irradiance (SSI, ~ 0.3–4.0 μm) is developed based on extensive radiative transfer simulations on a diversity of atmospheric conditions. In the new scheme, the accumulated SSI arriving at the surface is considered as a whole, but the different radiative attenuations, such as the ozone absorption, permanent gas absorption, water vapor absorption, Rayleigh scattering, aerosol absorption and scattering, and cloud absorption and scattering, are accounted for separately. In particular, for the cloud radiative attenuations, the single scattering and multiple scattering of clouds are parameterized respectively to improve the accuracy. Compared with the complicated spectral radiative transfer model of LibRadtran (Emde et al., 2016, https://doi.org/10.5194/gmd‐9‐1647‐2016), more than 90% of the SSI discrepancies are within ±5%, which means in theory the new parameterization scheme is very accurate. When the broadband parameterization scheme is practically applied to Moderate Resolution Imaging Spectroradiometer (MODIS) products, the validation results indicate that the high‐quality instantaneous SSI can be thus acquired. At eight sites over China, R2 ranges from 0.86 to 0.96 and all RMSEs lie within 100 W/m2, while at seven sites over the United States, R2 fluctuates within the range of 0.82–0.94 and the RMSEs at most sites are <90 W/m2, with the exception of Table Mountain. The performance of the new parameterization scheme is comparable to those of more complicated methods such as the look‐up‐table methods and the δ‐two‐stream approximation methods. But it is more attractive due to its simplicity and efficiency.
Down-regulation of HPGD by miR-146b-3p promotes cervical cancer cell proliferation, migration and anchorage-independent growth through activation of STAT3 and AKT pathways
Authors: Yao Shuihong , Xu Jingyun , Zhao Kaixuan , Song Pengxia , Yan Qin , Fan Weifei , Li Wan , Lu Chun 
Published: October 2018

AbstractWhile the application of early screening and HPV vaccines has reduced the incidence and mortality rates of cervical cancer, it remains the third most common carcinoma and fourth leading cause of cancer-associated death among women worldwide. The precise mechanisms underlying progression of cervical cancer are not fully understood at present. Here, we detected significant down-regulation of 15-hydroxyprostaglandin dehydrogenase (HPGD) in cervical cancer tissues. Overexpression of HPGD inhibited cervical cancer cell proliferation, migration and anchorage-independent growth to a significant extent. To clarify the mechanisms underlying HPGD down-regulation in cervical cancer, miRNA microarray, bioinformatics and luciferase reporter analyses were performed. HPGD was identified as a direct target of miR-146b-3p displaying up-regulation in cervical cancer tissues. Similar to the effects of HPGD overexpression, down-regulation of miR-146b-3p strongly suppressed proliferation, migration and anchorage-independent growth of cervical cancer cells. Furthermore, HPGD negatively regulated activities of STAT3 and AKT that promote cervical cancer cell proliferation. Notably, HPV oncogenes E6 and E7 were determined as potential contributory factors to these alterations. Our results collectively suggest that the HPGD/miR-146b-3p axis plays a significant role in cervical cancer and may serve as a potentially effective therapeutic target.
Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury
Authors: Kim Hyo Jeong , Joe Yeonsoo , Rah So-Young , Kim Seul-Ki , Park Se-Ung , Park Jeongmin , Kim Jin , Ryu Jinhyun , Cho Gyeong Jae , Surh Young-Joon , Ryter Stefan W. , Kim Uh-Hyun , Chung Hun Taeg 
Published: October 2018

AbstractCarbon monoxide (CO) can confer protection against cellular stress, whereas the potential involvement of autophagy and lysosomal biogenesis remains incompletely understood. We demonstrate here that the activation of protein kinase R (PKR)-like endoplasmic reticulum (ER) kinase (PERK) with CO increased the nuclear translocation of transcription factor EB (TFEB). PERK activation by CO increased intracellular Ca2+ concentration and the phosphatase activity of calcineurin against TFEB. Moreover, we found that in the deficiency of TFEB, CO not only failed to recruit Parkin to the mitochondria but also failed to increase expression of lysosomal genes such as Lamp1, CathB, and TPP1. Therefore, we suggest that CO increases mitophagy through TFEB nuclear translocation by PERK-calcinuerin activation. In addition, the inhibition of TFEB with siRNA against TFEB abrogated the increase of mtDNA with CO, markers of mitochondrial biogenesis such as PGC1α, NRF1, and TFAM, and the mitochondrial proteins COX II, COX IV, and cytochrome c. To investigate the effects of CO on mitochondrial homeostasis in vivo, mice were treated with lipopolysaccharide (LPS)/d-galactosamine (D-GalN). CO inhalation reduced liver injury after challenge with LPS/GalN. Furthermore, CO inhalation increased TFEB activation, mitophagy and mitochondrial biogenesis in mice treated with LPS/GalN. Our findings describe novel mechanisms underlying CO-dependent cytoprotection in hepatocytes and liver tissue via activation of TFEB-dependent mitophagy and associated induction of both lysosomal and mitochondrial biogenesis.
A therapeutic approach to pantothenate kinase associated neurodegeneration
Authors: Sharma Lalit Kumar , Subramanian Chitra , Yun Mi-Kyung , Frank Matthew W. , White Stephen W. , Rock Charles O. , Lee Richard E. , Jackowski Suzanne 
Published: October 2018

AbstractPantothenate kinase (PANK) is a metabolic enzyme that regulates cellular coenzyme A (CoA) levels. There are three human PANK genes, and inactivating mutations in PANK2 lead to pantothenate kinase associated neurodegeneration (PKAN). Here we performed a library screen followed by chemical optimization to produce PZ-2891, an allosteric PANK activator that crosses the blood brain barrier. PZ-2891 occupies the pantothenate pocket and engages the dimer interface to form a PANK•ATP•Mg2+•PZ-2891 complex. The binding of PZ-2891 to one protomer locks the opposite protomer in a catalytically active conformation that is refractory to acetyl-CoA inhibition. Oral administration of PZ-2891 increases CoA levels in mouse liver and brain. A knockout mouse model of brain CoA deficiency exhibited weight loss, severe locomotor impairment and early death. Knockout mice on PZ-2891 therapy gain weight, and have improved locomotor activity and life span establishing pantazines as novel therapeutics for the treatment of PKAN.
Deciphering synergetic core-shell transformation from [Mo6O22@Ag44] to [Mo8O28@Ag50]
Authors: Wang Zhi , Su Hai-Feng , Tung Chen-Ho , Sun Di , Zheng Lan-Sun 
Published: October 2018

AbstractThe structural transformation of high-nuclearity silver clusters from one to another induced by specific stimuli is of scientific significance in terms of both cluster synthesis and reactivity. Herein, we report two silver-thiolate clusters, [Mo6O22@Ag44] and [Mo8O28@Ag50], which are templated by isopolymolybdates inside and covered by iPrS− and PhCOO− ligands on the surfaces. Amazingly, the [Mo8O28@Ag50] can be transformed from [Mo6O22@Ag44] by adding PhCOOH which increases the degree of condensation of molybdates template from Mo6O228- to Mo8O288-, then enlarging the outer silver shell from Ag44 to Ag50. The evolution of solution species revealed by time-dependent electrospray ionization mass spectrometry (ESI-MS) suggests a breakage-growth-reassembly (BGR) transformation mechanism. These results not only provide a combined assembly strategy (anion-template + induced transformation) for the synthesis of silver-thiolate clusters but also help us to better understand the complex transformation process underpinning the assembly system.
Compact Optical Nerve Cuff Electrode for Simultaneous Neural Activity Monitoring and Optogenetic Stimulation of Peripheral Nerves
Authors: Song Kang-Il , Park Sunghee Estelle , Lee Seul , Kim Hyungmin , Lee Soo Hyun , Youn Inchan 
Published: October 2018

AbstractOptogenetic stimulation of the peripheral nervous system is a novel approach to motor control, somatosensory transduction, and pain processing. Various optical stimulation tools have been developed for optogenetic stimulation using optical fibers and light-emitting diodes positioned on the peripheral nerve. However, these tools require additional sensors to monitor the limb or muscle status. We present herein a novel optical nerve cuff electrode that uses a single cuff electrode to conduct to simultaneously monitor neural activity and optogenetic stimulation of the peripheral nerve. The proposed optical nerve cuff electrode is designed with a polydimethylsiloxane substrate, on which electrodes can be positioned to record neural activity. We confirm that the illumination intensity and the electrical properties of the optical nerve cuff electrode are suitable for optical stimulation with simultaneous neural activity monitoring in Thy1::ChR2 transgenic mice. With the proposed electrode, the limb status is monitored with continuous streaming signals during the optical stimulation of anesthetized and moving animals. In conclusion, this optical nerve cuff electrode provides a new optical modulation tool for peripheral nervous system studies.