bluuebunny/crossref_metadata_2025_split huggingface dataset:
Warm Surprises from Cold Duets: N-Body Simulations with Two-Component Dark Matter
Authors: Kim Jeong Han , Kong Kyoungchul , Lim Se Hwan , Park Jong-Chul 
Published: November 2024

Abstract
We explore extensive N-body simulations with two-component cold dark matter candidates. We delve into the temperature evolution, power spectrum, density perturbation, and maximum circular velocity functions. We find that the substantial mass difference between the two candidates and the annihilation of the heavier components to the lighter ones effectively endow the latter with warm dark matter-like behavior, taking advantage of all distinct features that warm dark matter candidates offer, without observational bounds on the warm dark matter mass. Moreover, we demonstrate that the two-component dark matter model aligns well with observational data, providing valuable insights into where and how to search for the elusive dark matter candidates in terrestrial experiments.
The association of objective daytime sleepiness with impaired glucose metabolism in patients with obstructive sleep apnea: a multi-omics study
Authors: Chen Le , Chen Baixin , Dai Yanyuan , Sun Qimeng , Wu Jun , Zheng Dandan , Vgontzas Alexandros N , Tang Xiangdong , Li Yun 
Published: November 2024

Abstract

Study Objectives
To examine the joint effect of obstructive sleep apnea (OSA) and objective excessive daytime sleepiness (EDS) on glucose metabolism and the underlying mechanisms.

Methods
We included 127 patients with OSA. The multiple sleep latency test (MSLT) and Epworth sleepiness scale (ESS) were used to assess objective and subjective EDS, respectively. Disordered glucose metabolism was defined as either a physician diagnosis or having fasting blood glucose levels ≥5.6 mmol/L. Values of fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) higher than the median values of our sample were defined as high fasting insulin and insulin resistance. Serum metabolomics and fecal microbiota were used to explore underlying mechanisms.

Results
Lower MSLT values were associated with higher levels of fasting blood glucose, fasting insulin, and HOMA-IR. Furthermore, objective EDS was associated with increased odds of disordered glucose metabolism, elevated fasting insulin, and insulin resistance. Dysregulation of serum valine degradation and dysbiosis of fecal Bacteroides thetaiotaomicron were associated with impaired glucose metabolism in OSA with objective EDS. No association between subjective EDS and impaired glucose metabolism was observed.

Conclusions
OSA with objective, but not subjective, EDS is associated with an increased risk of disordered glucose metabolism and insulin resistance. Dysregulation of valine degradation and dysbiosis of B. thetaiotaomicron appear to link objective EDS and disordered glucose metabolism in OSA.
Sleep and retrieval practice both strengthen and distort story recollection
Authors: Denis Dan , DiPietro Carissa , Spreng R Nathan , Schacter Daniel L , Stickgold Robert , Payne Jessica D 
Published: November 2024

Abstract
Over time, memories lose episodic detail and become distorted, a process with serious ramifications for eyewitness identification. What are the processes contributing to such transformations over time? We investigated the roles of post-learning sleep and retrieval practice in memory accuracy and distortion, using a naturalistic story recollection task. Undergraduate students listened to a recording of the “War of the Ghosts,” a Native American folktale, and were assigned to either a sleep or wake delay group, and either a retrieval practice or listen-only study condition. We found higher accuracy after sleep compared to wake in the listen-only condition, but not in the retrieval practice condition. This effect was driven by participants in the wake, retrieval practice condition showing superior memory compared to the wake, listen-only condition. A similar pattern was found for memory distortion, with both sleep and retrieval practice being associated with more inferences of nonpresented, but story-related information, compared to the wake, listen-only condition. These findings suggest both sleep and retrieval practice contribute to narrative memory stabilization and distortion.
Boosting Your Enemies to Garner the Sympathy of Friends: Pro-Fracking Industry Communications and the Geography of Contention
Authors: Walker Edward T , Vasi Ion Bogdan 
Published: November 2024

Abstract
Scholarship has recognized that contention shapes impression management efforts by business actors but has largely ignored how geographic factors affect industry-level responses and how industry groups may seek advantage based on the protests they face. This is consequential: against intuition, industry groups may respond more robustly to relatively more distant challenges than to ones proximate to their infrastructure, hoping to use this to their benefit. They do this because modestly further-away challenges can be framed as coming from “outsiders” making not-in-your-backyard claims, against claimed support in proximate communities. Using structural topic models, we examine daily communications by two major industry groups supporting hydraulic fracturing (“fracking”) between 2009 and 2019: one more transgressive, one more conventional. We examine how their communications shifted after both proximate and non-proximate antifracking contention (protests and bans). We find that they respond only to relatively more distant contention: the transgressive group boosts distant opponents seeking to delegitimize them, while the conventional group highlights economic benefits. Further, reflecting political partisanship, both associations respond only to distant contention emerging from politically liberal areas, ignoring similar contention in conservative areas. We discuss implications for theories of social movements, organizations, and environmental sociology.
The impact of hemoglobin concentration on farrowing duration in sows
Authors: McClellan Katlyn A , Sheffield Sydney L , Levesque Crystal L 
Published: November 2024

Abstract
Concerns have been raised about the prevalence of anemia in sows, yet our understanding of its consequences, particularly its impact on the farrowing process, remains limited. This study investigated the relationship between hemoglobin concentration (HbC) and farrowing duration in sows. A total of 101 sows (n = 16 parity 0, 15 parity 1, 24 parity 2, and 46 parity 3 sows) were monitored for blood HbC (Hemocue Hb 201 device) from the ear vein before farrowing (day 112 of gestation) and between 40 to 48 h after farrowing (day 2). Sows were categorized as anemic (HbC &lt; 10 g/dL), or nonanemic (HbC ≥ 10 g/dL) based on their day 112 HbC (i.e., prefarrowing status). Surveillance cameras recorded the farrowing process for each sow, complemented by human observation. Farrowing duration was defined as the time elapsed between the first piglet born and the last piglet born. All piglets were individually weighed within 18 h of birth, and stillborn piglets were identified using a lung flotation test conducted within 1 h of birth. The correlation between sow HbC, farrowing duration, and stillborn piglets was assessed using the PROC CORR procedure in SAS. Additionally, the effect of HbC category on labor duration was tested using the PROC MIXED procedure, with total piglets born included as a covariate. Anemic sows had a prolonged farrowing (7.2 h ± 0.92 min, P &lt; 0.001) compared to nonanemic sows (3.5 h ± 0.88 min), and negative correlation was observed between prefarrow HbC and farrowing duration (r = −0.62, P &lt; 0.001). There was a weak correlation between farrowing duration and stillborn piglets (r = 0.32, P = 0.01). No correlation was observed between farrowing duration and total born (r = 0.22, P = 0.11). There was no difference in total born (16.41 ± 0.7 vs 16.3 ± 0.7) between anemic (&lt; 10 g/dL) and nonanemic (≥10 g/dL) sows, respectively. Factors such as barn temperature on the day of parturition and feed intake the day prior did not influence the observed differences in labor duration between anemic and nonanemic sows. In conclusion, maintaining HbC above 10 g/dL appears beneficial for sows, as lower concentrations of HbC are associated with prolonged labor and increased removal rates. Blood HbC could serve as a valuable biomarker for identifying at-risk sows, thereby aiding in improving herd management and productivity.
Stress survival and longevity of Caenorhabditis elegans lacking NCS-1
Authors: Magno Luiz Alexandre Viana , Pinto Sofia Helena Dias Borges , Pacheco Ailla , Rosa Daniela Valadão Freitas , Gubert Priscila , Romano-Silva Marco Aurélio 
Published: November 2024

Abstract
Although dysfunctional Ca2+ signaling can trigger biochemical reactions that lead to cell death, the role of calcium-binding proteins (CBPs) in this process is still a topic of debate. Neuronal calcium sensor 1 (NCS-1) is a CBP that is highly conserved and has been shown to increase cell survival against various types of injuries. As such, we hypothesized that NCS-1 could also be a stress-responsive protein with potential effects on survival and longevity. To explore this possibility, we conducted experiments to examine how Caenorhabditis elegans ncs-1 mutant nematodes fared under three different stress conditions: hyperosmotic, thermal, and chemical oxidant challenges. Our results showed that while the lack of NCS-1 had no effect on survival responses to hyperosmotic and thermal stresses, ncs-1 worms demonstrated remarkable resistance to the oxidant paraquat in a dose-dependent manner. Based on these findings, we conclude that C. elegans may employ adaptive mechanisms in the absence of NCS-1 to survive specific oxidative stress stimuli.
Malignant transformation of recurrent benign phyllodes tumor: a case report and comprehensive review of literature
Authors: Khatiwada Abhikanta , Bastakoti Aashish , KC Sharada , Sharma Usha , Rao Shivali 
Published: November 2024

Introduction:
Phyllodes tumors (PTs) of the breast are rare fibroepithelial neoplasms, accounting for less than 1% of all breast tumors. The WHO classifies PTs into benign, borderline, or malignant categories based on histological features. While benign PTs generally have a favorable prognosis, they carry a risk of transformation into malignant variants, particularly in cases of recurrence.

Case presentation:
A 33-year-old female presented with a recurrent benign PT, previously treated with lumpectomy on two occasions. Recent imaging suggested possible malignant transformation, and histopathological examination confirmed a malignant PT.

Discussion:
This case highlights the crucial role of imaging in the early detection of malignant transformation in PTs. Surgical management strategies are discussed, with an emphasis on the potential for recurrent benign tumors to progress to malignancy.

Conclusion:
Regular imaging and close follow-up are essential for early detection of malignant transformation in recurrent PTs, guiding timely and appropriate surgical intervention.
Accuracy and Performance Characteristics of Administrative Codes for the Diagnosis of Autoinflammatory Syndromes
Authors: Lee Saeyun , Kim Sujin , Segerstrom Suzanne , Ferguson Polly J. , Lenert Aleksander 
Published: November 2024

Objective
The aim of this study was to evaluate and validate the accuracy and performance characteristics of administrative codes in diagnosing autoinflammatory syndromes (AISs).

Methods
We identified potential AIS patients from the electronic medical records at the University of Iowa Hospital and Clinics and the Stead Family Children's Hospital using a screening filter based on the 10th edition of the International Classification of Diseases (ICD-10) codes and interleukin-1 antagonists. Diagnostic criteria for adult-onset Still disease, systemic juvenile idiopathic arthritis, Behçet disease (BD), familial Mediterranean fever (FMF), cryopyrin-associated periodic syndrome (CAPS), and SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome and chronic nonbacterial osteomyelitis (SAPHO-CNO) were reviewed for each patient. Patients who did not meet the diagnostic criteria were categorized as non-AIS. In this cross-sectional study, we calculated the sensitivity, specificity, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve for the ICD codes in diagnosing AIS.

Results
Out of the 502 patients with potential AIS, 338 patients (67%) had a true AIS diagnosis. Sensitivity ranged from 80% (SAPHO-CNO) to 100% (BD and FMF), and positive predictive value ranged from 15% (FMF) to 80% (SAPHO-CNO). Specificity ranged from 81% (FMF) to 99% (CAPS and SAPHO-CNO), whereas negative predictive value ranged from 98% (adult-onset Still disease) to 100% (systemic juvenile idiopathic arthritis, BD, FMF, and CAPS). All ICD codes or code combinations for the diagnosis of specific AIS subtypes showed high accuracy with areas under the receiver operating characteristic curve ≥0.89.

Conclusions
This study validated the accuracy of administrative codes for diagnosing AIS, supporting their use in constructing AIS cohorts for clinical outcomes research.
Bitter taste genetics and oral health in Canadian Longitudinal Study on Aging
Authors: Shafizadeh Marziyeh , Bhatia Vikram , Ahmed Samah , Drögemöller Britt , Stavropoulou Chrysi , John Philip St. , Bhullar Rajinder P. , Chelikani Prashen , Hitchon Carol A. 
Published: November 2024

SUMMARYThis study aimed to investigate the association of single nucleotide polymorphisms (SNPs) in 25 Bitter Taste Receptor genes (TAS2Rs) and 12TAS2Rpseudogenes with self-reported oral health outcomes in the Canadian Longitudinal Study on Aging (CLSA) cohort. Following quality control, 124 SNPs with a minor allele frequency > 0.01 and 21,991 individuals of European ancestry were included in the analysis. Fifteen SNPs inTAS2R8, 9, 13, 14, 20, and50were significantly associated with self-reported sore jaw muscles, a symptom commonly linked to temporomandibular disorders (TMDs).TAS2R20exhibited the highest number of associated SNPs. Structure-function analysis suggests that variants inTAS2R20may contribute to this symptom by altering ligand interactions. These findings highlight the potential forTAS2Rgenetic screening to identify individuals at elevated risk for TMD, supporting the development of personalized treatment strategies and advancing our understanding of TMD genetic risk factors.
An Open Access Resource for Marmoset Neuroscientific Apparatus
Authors: Rollin Isabela Zimmermann , Papoti Daniel , Bishop Mitchell , Szczupak Diego , Corigliano Michael R. , Hitchens T. Kevin , Zhang Bei , Pell Sarah K. A. , Guretse Simeon S. , Dureux Audrey , Murai Takeshi , Sukoff Rizzo Stacey J. , Klassen L. Martyn , Zeman Peter , Gilbert Kyle M. , Menon Ravi S. , Lin Meng-Kuan , Everling Stefan , Silva Afonso C. , Schaeffer David J. 
Published: November 2024

AbstractThe use of the common marmoset (Callithrix jacchus) for neuroscientific inquiry has grown precipitously over the past two decades. Despite windfalls of grant support from funding initiatives in North America, Europe, and Asia to model human brain diseases in the marmoset, marmoset- specific apparatus are of sparse availability from commercial vendors and thus are often developed and reside within individual laboratories. Through our collective research efforts, we have designed and vetted myriad designs for awake or anesthetized magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), as well as focused ultrasound (FUS), electrophysiology, optical imaging, surgery, and behavior in marmosets across the age- span. This resource makes these designs openly available, reducing the burden of de novo development across the marmoset field. The computer-aided-design (CAD) files are publicly available through the Marmoset Brain Connectome (MBC) resource (https://www.marmosetbrainconnectome.org/apparatus/) and include dozens of downloadable CAD assemblies, software and online calculators for marmoset neuroscience. In addition, we make available a variety of vetted touchscreen and task-based fMRI code and stimuli. Here, we highlight the online interface and the development and validation of a few yet unpublished resources: Software to automatically extract the head morphology of a marmoset from a CT and produce a 3D printable helmet for awake neuroimaging, and the design and validation of 8-channel and 14- channel receive arrays for imaging deep structures during anatomical and functional MRI.
Molecular Basis of Sperm Methylome Response to Aging and Stress
Authors: Arowolo Olatunbosun , Zhu Jiahui , Nowak Karolina , Pilsner J Richard , Suvorov Alexander 
Published: November 2024

ABSTRACTChanges in the sperm epigenome induced by age and/or stressors often follow common unexplained patterns affecting genes responsible for embryonic development and neurodevelopment. The stochastic epigenetic variation (SEV) hypothesis proposes that in response to stressors naturally variable methylation regions (VMRs) associated with morphogenic genes increase in methylation variation to diversify phenotypes and improve chances of survival of the genetic lineage. Here, we test predictions from the SEV hypothesis using mouse and rat sperm DNA methylation and other -omics data. We demonstrate that the context of DNA regions determines the response of sperm methylome to various factors rather than the stressors and/or timing of these factors. We propose a model explaining age/stress-dependent shifts in methylation in VMRs by an asymmetric increase in methylation variation of these regions. Because methylation variation in VMRs increases with age, sperm methylome response to stressors may be characterized as an acceleration of epigenetic aging.
Proteostasis Associated Mutations in HSPB5 Destabilize the αB-crystallin Domain
Authors: Khatun Mst. Shanzeda , Ali Md. Chayan , Barua Largess , Munni Yeasmin Akter , Dash Raju , Rahman Md Mafizur 
Published: November 2024

AbstractHSPB5 (αB-crystallin) is an ATP-independent, stress-inducible chaperone protein that improves protein misfolding and degradation in proteotoxicity-related diseases, including several myopathies, neurodegenerative diseases, and cancers. Although single nucleotide polymorphism (SNP) reduces the overall activity of HSPB5, its dynamic behaviour remains unknown. To get molecular insights into the deleterious, pathogenic, and proteotoxicity-related mutations, this study investigates the potential deleterious SNPs associated with HSPB5. Notably, eleven computational tools identified D109H, R120G, and D140N as the most deleterious SNPs from a total of 313 missense SNPs. Interestingly, these three mutations are present in the core αB-crystallin (αB-c) domain. A molecular dynamics simulation for 500 ns was conducted to reveal these variants’ mechanistic insights. The mutant variants showed higher flexibility and significant conformational changes than the wild, which might be noteworthy to reduce these variants’ chaperoning activity. Also, this conformational change elucidated the loss of function mutations, which could alter these variants’ oligomeric properties. This study will help our understanding of the role and molecular mechanism of HSPB5 mutations in proteotoxicity vulnerable diseases.
International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortium
Authors: Moore Andrew R , Zheng Hong , Ganesan Ananthakrishnan , Hasin-Brumshtein Yehudit , Maddali Manoj V , Levitt Joseph E , van der Poll Tom , Scicluna Brendon P , Giamarellos-Bourboulis Evangelos J. , Kotsaki Antigone , Martin-Loeches Ignacio , Garduno Alexis , Rothman Richard E. , Sevransky Jonathan , Wright David W , Atreya Mihir R. , Moldawer Lyle L. , Efron Philip A , Marcela Kralovcova , Karvunidis Thomas , Giannini Heather M. , Meyer Nuala J. , Sweeney Timothy E , Rogers Angela J , Khatri Purvesh 
Published: November 2024

ABSTRACTProgress in the management of critical care syndromes such as sepsis, Acute Respiratory Distress Syndrome (ARDS), and trauma has slowed over the last two decades, limited by the inherent heterogeneity within syndromic illnesses. Numerous immune endotypes have been proposed in sepsis and critical care, however the overlap of the endotypes is unclear, limiting clinical translation. The SUBSPACE consortium is an international consortium that aims to advance precision medicine through the sharing of transcriptomic data. By evaluating the overlap of existing immune endotypes in sepsis across over 6,000 samples, we developed cell-type specific signatures to quantify dysregulation in these immune compartments. Myeloid and lymphoid dysregulation were associated with disease severity and mortality across all cohorts. This dysregulation was not only observed in sepsis but also in ARDS, trauma, and burn patients, indicating a conserved mechanism across various critical illness syndromes. Moreover, analysis of randomized controlled trial data revealed that myeloid and lymphoid dysregulation is linked to differential mortality in patients treated with anakinra or corticosteroids, underscoring its prognostic and therapeutic significance. In conclusion, this novel immunology-based framework for quantifying cellular compartment dysregulation offers a valuable tool for prognosis and therapeutic decision-making in critical illness.
Follow-up of cancer incidence associated with smoke-related PM2.5exposure due to a coal mine fire
Authors: Nayagam Sunav N , Yu Pei , Gao Caroline X , Smith Catherine L , Ikin Jillian F , Brown David , Kinsman Natasha , Guo Yuming , Abramson Michael J , Walker-Bone Karen , Sim Malcolm R , Lane Tyler J 
Published: November 2024

AbstractBackgroundThe link between chronic exposure to ambient PM2.5and lung cancer is well established. However, there is limited evidence on the effects of more acute, high-level exposure such as that resulting from the 2014 Hazelwood coal mine fire in regional Australia. We investigated the effects of PM2.5from the mine fire on cancer incidence 8.5 years later.MethodologyWe obtained Victorian Cancer Registry data linked to 2872 Hazelwood Health Study Adult Cohort members, for the period August 2014 to December 2022. Individual fire-related PM2.5exposure was estimated by blending time-location diaries with spatial and temporal air pollution modelling data. To assess the cancer risk associated with fire related PM2.5exposure, we employed competing risk regression models, accounting for people who died from causes other than cancer during follow-up and adjusting for confounders, including cigarette smoking.ResultsIn the post-mine fire period, 295 people (14.3/1000 person-years) were diagnosed with 332 new cancers (12.7/1000 person-years). No significant association was found between fire-related PM2.5exposure and the overall incidence of cancer (HR = 1.00, 95%CI: 0.90-1.11). Additionally, no associations were identified with any specific cancer subtypes, including lung cancer. However, a higher risk of overall cancer incidence was observed in Morwell compared with Sale, (HR = 1.27, 95% CI: 0.93–1.73).ConclusionsWhile we found no evidence that this coal mine fire increased cancer incidence, it would be premature to rule out potential carcinogenic effects. Cancer has a long latency period, which means it will be necessary to analyse new data as they become available to more conclusively determine the effects of medium-duration, high-level smoke exposure.