bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Serum Folate Level and Toxicity of Capecitabine During Treatment for Colorectal Cancer
Authors: Chan Stephen L. , Chan Anthony W.H. , Mo Frankie , Ma Brigette B.Y. , Wong Kenneth C.W. , Lam Daisy , Mok Florence S.T. , Chan Anthony T.C. , Mok Tony , Chan K.C. Allen 
Published: May 2018

Abstract

Background
Folate level was proposed to be a predictor for fluoropyrimidine-related toxicity. We conducted a prospective study to determine the association between serum and red-cell folate and capecitabine-related toxicity in patients with colorectal cancers.

Materials and Methods
Eligibility criteria included diagnosis of colorectal cancers; eligible patients who were scheduled to undergo capecitabine monotherapy or capecitabine-oxaliplatin (CAPOX) for adjuvant or palliative purposes. Exclusion criteria included concomitant radiotherapy or chemotherapy other than capecitabine or CAPOX and creatinine clearance &lt;30 mL/min. Fasting serum and red-cell folate were measured prior to chemotherapy. Capecitabine was administered at 2,500 mg/m2 per day (monotherapy) or 2,000 mg/m2 per day (CAPOX) for 14 days every 3 weeks. The toxicity of the first four cycles was documented by clinical investigators who were blinded to folate levels.

Results
A total of 144 patients were recruited, of whom 126 were eligible; 40 patients had capecitabine alone, and 86 patients received CAPOX. The rates of grade 2 and grade 3 toxicity were 63.5% and 14.3%, respectively. Nausea and vomiting were the most common grade ≥2 adverse event (47.7%), followed by hand-foot syndrome (25.4%), diarrhea (23.1%), and neutropenia (22.3%). Combination with oxaliplatin (odds ratio [OR], 2.77; p = .043) and serum folate (OR, 10.33; p = .002) were independent predictors of grade ≥2 toxicity. Red-cell folate was not predictive of toxicity. For every 10 nmol/L increment in serum folate, the risk of grade ≥2 toxicity increased by 9%.

Conclusion
Serum folate level, but not red-cell folate, was associated with higher rate of grade ≥2 toxicity during capecitabine-based treatment. Excessive folate intake may be avoided before and during capecitabine-based chemotherapy.

Implications for Practice
This is the first prospective study to evaluate the association between serum folate level and capecitabine-related toxicity in patients with colon cancers. It shows that higher serum folate level is associated with increased risks of moderate to severe toxicity during capecitabine-based treatment. Excessive folate intake should be avoided before and during capecitabine-based chemotherapy.
Comparación de los puntajes PAS y Lintula en la sospecha diagnóstica de apendicitis en niños
Authors: Mujica Guevara Jorge Alberto , Pierdant Pérez Mauricio , Gordillo Moscoso Antonio Augusto , Martínez Martínez Marco Ulises , Ramírez Meléndez Raymundo 
Published: May 2018

INTRODUCCIÓN: la apendicitis aguda es la principal causa de cirugía abdominal en niños. En ocasiones es difícil distinguir la apendicitis de otros padecimientos y ello puede retrasar el diagnóstico. Los puntajes PAS (Pediatric Apendicitis Score) y Lintula se basan en la existencia, o no, de síntomas y signos validados en oblación pediátrica. No existen estudios prospectivos (en el mismo grupo poblacional) que informen cuál de ellos es más útil en la evaluación del niño con sospecha de apendicitis.OBJETIVOS: comparar los puntajes Lintula y PAS y establecer cuál es más confiable ante la sospecha diagnóstica de apendicitis en niños.MATERIALES Y MÉTODOS: estudio prospectivo efectuado en pacientes pediátricos de 4 a 15 años atendidos en el servicio de urgencias pediátricas de un hospital de segundo nivel de atención entre los meses de febrero y agosto de 2015, por dolor abdominal y sospecha de apendicitis. Ambos sistemas de puntaje se calificaron por paciente, el diagnóstico definitivo se estableció con base en el estudio anatomopatológico o la evolución clínica. RESULTADOS: se incluyeron 100 pacientes y la apendicitis se confirmó en 47. El puntaje Lintula promedio de casos sin apendicitis fue de 12.5 (DE ± 6.2) y con apendicitis 28.8 (DE ± 5.2) (p < 0.001). La puntuación media para PAS en los casos sin apendicitis fue de 4.3 (DE ± 2.1) y con apendicitis 8.3 (DE ± 1.5) (p < 0.001). El mejor punto de corte en las curvas ROC fue de 20 para Lintula y 6 para PAS. Para Lintula la sensibilidad fue de 89.4%, especificidad 90.6% y área bajo la curva de 0.942. El PAS arrojó sensibilidad 95.7%, especificidad 75.5% y área bajo la curva de 0.924. No se encontraron diferencias significativas entre los instrumentos.CONCLUSIONES: puesto que ambos instrumentos tienen sensibilidad y especificidad apropiadas debe alentarse su aplicación en la valoración de la sospecha de apendicitis en niños.
BIFOCAL: performance dialógica sobre o quadro relacional do espaço da Universidade
Authors: Pinto Ferreira Jairo Reiges 
Published: May 2018

<p> </p><p><strong>RESUMO</strong></p><p> </p><p>Pelas produções científicas,ogrupo PesquisAtores busca expandir suas apresentações artísticas, para que alcance outros públicos, despertando sensibilidades, como se o acontecimento estivesse diante de sua leitura e não se perdesse em uma data. Partindo dos princípios norteadores de Eleonora Fabiãosobre <em>performance</em>, pela BIFOCAL é apresentado relações do eu consigo, do eu com o outro e do eu com o espaço na Universidade. Organizado em etapas, assim como na <em>performance</em>,o artigo traz os detalhes de como surgiu a proposta,em seguida, por citações e suposições de situações são apresentados tópicos de discussões e finda, com o relato de impressões dos performers. </p><p> </p><p>Palavras – chave: Performance. Relação. Espaço. </p>
Keabsahan Perkawinan Hukum Adat Lombok (Merarik) Ditinjau dari Perspektif Undang-Undang Nomor 1 Tahun 1974 tentang Perkawinan dan Hukum Islam (Studi di Kabupaten Lombok Tengah)
Authors: Anggraeny Baiq Desy 
Published: May 2018

Merarik merupakan perkawinan suku adat Sasak yang kaya dengan nilai-nilai budaya dan merupakan kearifan lokal yang dimiliki masyarakat suku Sasak. Merarik dalam suku Sasak adalah membawa lari calon pengantin perempuan oleh calon pengantin lelaki ke tempat keluarga si lelaki untuk disembunyikan dengan tujuan supaya dapat dinikahi dan dijadikan istri. Perkawinan hukum adat Lombok (Merarik) dalam perspektif UU No. 1 Tahun 1974 tentang Perkawinan dan Hukum Islam adalah sah baik secara hukum positif dan hukum Islam karena perkawinan Merarik proses adat-istiadatnya saja yang berbeda, sedangkan yang lainnya sama baik mengikuti ketentuan UU No. 1 Tahun 1974 tentang Perkawinan maupun syarat-syarat yang terdapat dalam hukum Islam.Merarik is a marriage of indigenous Sasak tribe that is rich with cultural values and merarik is a local wisdom owned by the Sasak tribe community. Merarik in the Sasak tribe is bringing the bride ran by the bridegroom to the man's family to be hidden in order to be married and made wife. The marriage of the customary law of Lombok (Merarik) in the perspective of Law no. 1 of 1974 on Marriage and Islamic Law is lawful both positive and Islamic law Because marriage Merarik process of customs are different, while others are equally well following the provisions of Law no. 1 Year 1974 on Marriage and the conditions contained in Islamic law.
A pedagogia do esporte aplicada às lutas
Authors: Lourenço Filho Armando 
Published: May 2018

Pedagogia do esporte aplicada às lutas foi escrito a partir da monografia de graduação de 2006 do autor Mauro Breda, que é especialista em Ciências do Esporte pela UNICAMP, graduado em Educação Física pelo Centro Universitário Adventista de São Paulo, faixa preta, terceiro Dan em caratê de contato e ministra aulas da modalidade dentro e fora do Brasil. Os outros autores têm sua formação na área de Educação Física pela UNICAMP: Larissa Galatti é mestre, Alcides José Scaglia é doutor e Roberto Rodrigues Paes é doutor e professor livre-docente da graduação e pós-graduação na mesma instituição.
Formação de professores Guarani e Kaiowá: interculturalidade e decolonialidade no ensino de matemática
Authors: Oliveira Maria Aparecida Mendes , Mendes Jackeline Rodrigues 
Published: May 2018

O presente artigo propõe uma reflexão sobre as relações entre saberes (matemáticos) de diferentes matizes/origens, provenientes das práticas culturais de um determinado grupo étnico e do mundo acadêmico e escolar, no processo de formação inicial de professores indígenas, bem como na formação continuada, a partir de sua inserção nos anos finais do Ensino Fundamental e no Ensino Médio em escolas indígenas de suas comunidades. A reflexão aqui apresentada é sustentada em estudos sobre interculturalidade e decolonialidade do saber. Partimos da fala de professores Guarani e Kaiowá, em Mato Grosso do Sul, egressos do curso de Licenciatura Intercultural Indígena da Universidade Federal da Grande Dourados-UFGD. As falas destes profissionais da educação revelam os tensionamentos produzidos nessas relações e coloca em questionamento a lógica de hierarquização entre os saberes presentes no modelo de colonialidade. As relações entre saberes, estabelecidos no modelo imposto pelas estruturas, pelos sistemas de poder e pelos conhecimentos coloniais, mantidos e reproduzidos nos espaços institucionais, são colocadas em questão com a presença dos indígenas na universidade e nas escolas indígenas. E esta presença configura como processo de resistência a este modelo. Desta forma, interculturalidade e a decolonialidade são projetos que estão ligados à luta por uma escola indígena diferenciada, e sempre em construção, permeada por uma série de tensões.
Use of a Total Shoulder Arthroplasty in a Patient with Minimally Painful Severe Glenohumeral Arthritis and a Progressive Plexopathy
Authors: Triplet Jacob J. , Kurowicki Jennifer , Rosas Samuel , Levy Jonathan C. 
Published: May 2018

Case:
A 70-year-old woman presented with severe but minimally painful right glenohumeral osteoarthritis (OA), with progressive weakness and numbness radiating to the right hand. Imaging revealed a large fluid collection extending from the joint to the subcoracoid space, with a mass effect on the brachial plexus. A total shoulder arthroplasty (TSA) and decompression of a ganglion cyst were performed. Follow-up with serial electromyography demonstrated resolution of the brachial plexopathy and restoration of function.

Conclusion:
Ganglion cysts may arise secondary to severe glenohumeral OA and may compress the surrounding structures, producing a progressive plexopathy. Treatment of the underlying pathology with a TSA may be effective.
New Tubular-Design Ellipse With Backup Pressure
Authors: Goodman Malcolm A. , Kalil Issa A. , McSpadden Albert R. , Coker Oliver D. 
Published: May 2018

Summary
This paper proposes a tubular-design ellipse dependent on backup pressure (internal pressure for collapse and external pressure for burst), so that the latest American Petroleum Institute (API) collapse-resistance equations (API TR 5C32015) with dependence on internal pressure can be shown simultaneously on the same plot with the ellipse. Unlike the current ellipse used widely in the industry for casing-and-tubing design, which is approximate, the proposed ellipse is exact for collapse, burst, and axial loads. Without the proposed ellipse, use of the approximate ellipse will continue, requiring separate plots for the API collapse-resistance equations. Example cases demonstrate the advantages of the proposed ellipse, including increased accuracy. Results help clarify questions regarding the origin and use of the 2015 API collapse-resistance equations.
New Insights into Soybean Biological Nitrogen Fixation
Authors: Ciampitti Ignacio A. , Salvagiotti Fernando 
Published: May 2018

Core Ideas
As N2 fixation (%) increased, seed production per N2 fixation decreased.
The N‐gap between crop N uptake and N supplied by N2 fixation rose when contribution from biological N2 fixation increased.
The partial N balance revealed negative values across all N derived from the atmosphere levels.
Yield was negatively related to partial N balance when N derived from the atmosphere was below 42%.
Soybean biological N2 fixation (BNF) relationships with fertilizer N and yield response have been comprehensively reviewed in the scientific literature. However, the study of the N‐gap between N uptake and N supplied by N2 fixation, and the partial N balance (fixed N in aboveground biomass – N seeds) needs further investigation. Therefore, the goals of this synthesis–analysis were to (i) quantify seed production per unit of fixed N under different amounts of N derived from the atmosphere (NDFA, %), (ii) study the N‐gap and explore limitations of N2 fixation (kg ha−1) for satisfying plant N demand, and (iii) calculate a partial N balance for soybean and determine its relationship with the N2 fixation process. Data was gathered from 1955 through 2016 using studies reporting BNF, seed yield, and plant N uptake (n = 733 data points). The main outcomes of this review were (i) as NDFA increased, seed production per N2 fixation decreased (from 0.033 to 0.017 Mg yield kg−1 N from low, 28%, to high, 80%, NDFA); (ii) N‐gap increased faster when NDFA values were above 80% and after plant N content was above 370 kg N ha−1 suggesting that the crop needs additional N for coping yield potential; and (iii) when excluding roots, the partial N balance calculation revealed negative values across all NDFA levels. Future studies should consider a holistic approach to quantify the contribution of BNF in overall N cycling, including N contribution from roots, and to better understand the soil × plant × rhizobia interactions.
Screening of marigold (Tagetes erecta L.) cultivars for drought stress based on vegetative and physiological characteristics
Authors: Younis Adnan , Riaz Atif , Qasim Muhammad , Mansoor Farakh , Zulfiqar Faisal , Tariq Usman , Ahsan Muhammad , Naseem M. Kaleem , Bhatti Zahid Mukhtar 
Published: May 2018

<p>Drought tolerance is an important genotypic character to be exploited for the plant cultivar selection under water deficit conditions. In the recent study, we examined the response of two marigold cultivars (Inca and Bonanza) under different regimes of drought stress. The aim was to determine the best performing cultivar under water/drought stress. Three irrigation treatments include; 4 days (T<sub>1</sub>), 6 days (T<sub>2</sub>) and 8 days (T<sub>3</sub>) in comparison to control 1 day (T<sub>0</sub>) interval were imposed. Response characters under study were morphological, physiological and anatomical. Complete Randomized Design (CRD) with four replications in two factorial arrangements was followed for experiment layout. The results revealed that increasing water stress adversely affect plant height, in both cultivars. Both cultivars showed a decreasing trend to the number of flowers under water stress. Total chlorophyll contents including a, b were also showed reduction under prolonged drought treatment in both cultivars from (2.7 mg g<sup>-1</sup> FW) to (1 mg g<sup>-1</sup> FW). Overall, the performance of cultivar (cv.) Inca was satisfactory under water stress regimes. These results are helpful for selecting drought tolerant marigold cultivars in water scarce areas. </p>
Efecto del subproducto industrial CaCO3 en los atributos de calidad, contenido fenólico y capacidad antioxidante de manzana cvs Golden Delicious y Top Red
Authors: Flores Córdova María Antonia , Soto Parra Juan Manuel , Salas Salazar Nora Aide , Sánchez Chávez Esteban , Piña Ramírez Francisco Javier 
Published: May 2018

Introducción: El calcio, es un nutriente importante para aumentar la calidad y rendimiento en los cultivos hortofrutícolas, ya que es considerado como el mineral más importante para la calidad de las manzanas, algunas investigaciones han demostrado su incidencia en la reducción de ciertas alteraciones fisiológicas (bitter pit, corazón acuoso y la descomposición interna), conseración de la firmeza de la pulpa y prevenir la incidencia de podredumbres fúngicas. El objetivo del presente estudio fue evaluar el efecto del subproducto industrial carbonato de calcio (CaCO3) en los atributos de calidad, contenido fenólico y capacidad antioxidante de manzanas cvs Golden Delicious y Top Red.Método: Se utilizaron árboles de 21 años de edad cultivados en la región de Cuauhtémoc, Chihuahua. México, los tratamientos fueron Kg ha-1 de CaCO3 (y su equivalente en Ca por ha): Testigo sin aplicación T1, 282.70 (100) T2;565.30 (200) T3; 847.90 (300) T4; 1130.60 (400) T5;1413.20 (500) T6; 1695.90 (600) T7; 1978.50 (700) T8; 2261.20 (800) T9;2543.80 (900) T10; 2826.50 (1000) T11; 3957.00 (1400) T12 respectivamente. Las variables evaluadas fueron: contenido de Ca, rendimiento, diámetro, peso, color, firmeza, sólidos solubles, acidez titulable, relación SST/acidez titulable, fenoles totales y capacidad antioxidante por el metódo de DPPH. Resultados: Los resultados mostraron diferencias estadísticas (p ≤ 0.05) entre cultivares, los tratamientos incrementaron el contenido de Ca, la firmeza fue significativamente más alta, el cultivar Top Red presentó los valores más altos de compuestos fenólicos con 3.587 mg g-1 de ácido gálico, mientras que el cultivar Golden Delicious presentó la mayor capacidad antioxidante con 2.27 mg g-1 de Trolox. Discusión o Conclusión: Se concluye que la aplicación de CaCO3 influyó en los parámetros de calidad, contenido de compuestos fenólicos y capacidad antioxidante en las cultivares Top Red y Golden Delicious.
Evaluación de la tenacidad a la fractura de anclajes de aceros colados de un puente atirantado por ensayo miniatura de punzonamiento
Authors: López-Vargas Erik , Alcaraz Caracheo Luis Alejandro , Álvarez José Alberto , Lacalle Roberto , Rodríguez-Castro Ramón , Martínez-Madrid Miguel , Sánchez-Rodríguez Álvaro 
Published: May 2018

La evaluación de la vida residual de componentes estructurales en servicio requiere conocer el valor de la tenacidad a la fractura, pero los métodos convencionales para medir la tenacidad demandan remover grandes cantidades de material del componente, lo cual es generalmente impráctico. Sin embargo, el Ensayo Miniatura de Punzonamiento (EMP) (que utiliza especímenes miniatura no estandarizados) ha sido empleado como una alternativa práctica y conveniente para evaluar las características de fractura del material de componentes en servicio. El propósito de esta investigación fue encontrar una relación entre la deformación a la fractura equivalente de EMP εaf y la tenacidad a la fractura JIC de aceros colados de baja aleación procedentes de anclajes de un puente atirantado localizado en el Golfo de México. La tenacidad a la fractura JIC se calculó a partir de los datos experimentales reportados de KIC en un trabajo previo y la deformación a la fractura equivalente se obtuvo mediante el EMP empleando especímenes de 10x10 mm2 por 0.5 mm de espesor. A partir de los resultados de εaf y JIC obtenidos, y correspondientes datos de aceros de baja aleación de la literatura, una correlación lineal fue propuesta para estimar la tenacidad de fractura a partir de la deformación a la fractura equivalente del EMP para los aceros colados pertenecientes a este caso de estudio.
Oligopeptides for Immunotherapy Approaches in Ovarian Cancer Treatment
Authors: Kanduc Darja 
Published: May 2018

Background:
Anti-ovarian cancer vaccines based on minimal immune determinants uniquely
expressed in ovarian cancer biomarkers appear to promise a high level of sensitivity and specificity for
ovarian cancer immunodiagnostics, immunoprevention, and immunotherapy.

Methods:
Using the Pir Peptide Match program, three ovarian cancer biomarkers – namely, sperm surface
protein Sp17, WAP four-disulfide core domain protein 2, and müllerian-inhibiting substance – were
searched for unique peptide segments not shared with other human proteins. Then, the unique peptide
segments were assembled to define oligopeptides potentially usable as synthetic ovarian cancer antigens.

Results and Conclusion:
This study describes a methodology for constructing ovarian cancer biomarkerderived
oligopeptide constructs that might induce powerful, specific, and non-crossreactive immune
responses against ovarian cancer.
Oxaliplatin Regulates Chemotherapy Induced Peripheral Neuropathic Pain in the Dorsal Horn and Dorsal Root Ganglion via the Calcineurin/NFAT Pathway
Authors: Huang Wan , Huang Jingxiu , Jiang Yu , Huang Xuanwei , Xing Wei , He Yaoxuan , Ouyang Handong 
Published: May 2018

Objective: The aim of this study was to investigate the mechanism of oxaliplatin in the induction of
neuropathic pain as a symptom of Chemotherapy-Induced Peripheral Neuropathy (CIPN).

Methods:
The CIPN rat model was induced with a one-time injection of oxaliplatin, and the paw withdrawal
response was determined using von Frey filaments. The Paw Withdrawal Threshold (PWT) value was recorded
and the Dorsal Horn (DH) and Dorsal Root Ganglion (DRG) tissues were collected. The mRNA and protein
levels of Calcineurin (CaN), Nuclear Factor of Activated T cells (NFAT), and other relevant cytokines were
determined. CaN and NFAT inhibition reagents, FK506 and 11R-VIVIT, were applied in order to investigate the
functions of the CaN/NFAT pathway in the neuropathic pain processes. The levels of the downstream inflammatory
cytokines, TNF-α and IL-1β, were assessed by ELISA.

Results:
The application of oxaliplatin reduced the value of PWT by 4 times on days 7（4±1.33）and
14（5.13±3.07）compared with the control group(14±0.91; 13.67±0.76). After treatment, the CaN mRNA level
decreased and that of NFAT increased in DH and DRG tissues (P<0.05). However, treatment with FK506 and
11R-VIVIT decreased the value of PWT that had increased after oxaliplatin treatment. The expression of downstream
cytokines related to the CaN/NFAT pathway increased, including CCR2, COX2, p-ERK, and p-P38 (all
p<0.05). In addition, when the CaN/NFAT pathway was activated, the concentration of TNFα increased to
40pg/mg in DH tissues and 60pg/mg in DRG tissues compared with the control group, while the concentration
of IL-1β increased to over 60pg/mg in DH and DRG tissues.

Conclusion:
It was the first time to prove that oxaliplatin-induced neuropathic pain was correlated to the activation
of the CaN/NFAT pathway in our rat model. This finding can provide a new direction to explore the
mechanism of oxaliplatin-induced neuropathic pain.
Aktualisasi Diri Calon Guru Bahasa Inggris Dalam 21st Century Learning
Authors: Purwaningtyas Agnes Siwi 
Published: May 2018

Language teaching in the 21st century should accommodate various skills that must be acquired by the students which include skills to analyze and solve problems, create and innovate, think critically, collaborate, and communicate. Language teachers should also integrate information and communication technology in the learning process to improve the quality of learning instruction and help to reach those learning goals. Addressing these challenges, teachers as well as teacher candidates need to develop their qualities and keep updating their knowledge. Teaching training program in the university therefore offer courses and programs to improve the competence and skills of the teacher candidates. English Program of Vocational College of Universitas Gadjah Mada also offer similar training although it is not extensively implemented since it only covers the introductory foundation for language teaching. Nevertheless, the students successfully demonstrate their teaching potentials and self-actualize themselves as teachers. The results of questionnaire, observation, and reflection show that the teacher candidates actualize their potentials as decision maker, designer, manager, learning facilitator, motivator, as well as creative, reflective, technology-literate, self-efficacious, and communicative teacher.