bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gait speed and prognosis in patients with idiopathic pulmonary fibrosis: a prospective cohort study
Authors: Nolan Claire M. , Maddocks Matthew , Maher Toby M. , Banya Winston , Patel Suhani , Barker Ruth E. , Jones Sarah E. , George Peter M. , Cullinan Paul , Man William D-C. 
Published: November 2018

The 4-m gait speed (4MGS), a simple physical performance measure and surrogate marker of frailty, consistently predicts adverse prognosis in older adults. We hypothesised that 4MGS could predict all-cause mortality and nonelective hospitalisation in patients with idiopathic pulmonary fibrosis (IPF).4MGS and lung function were measured at baseline in 130 outpatients newly diagnosed with IPF. Survival status and nonelective hospital admissions were recorded over 1 year. We assessed the predictive value of 4MGS (as a continuous variable and as a binary variable: slowversuspreserved 4MGS) by calculating hazard ratios using Cox proportional regression, adjusting for potential confounding variables. Receiver operating characteristic curves assessed discrimination between the multivariable regression models and established prognostic indices.Continuous 4MGS and slow 4MGS were independent predictors of all-cause mortality (4MGS: HR 0.03, 95% CI 0.01–0.31; p=0.004; slow 4MGS: 2.63, 95% CI 1.01–6.87; p=0.049) and hospitalisation (4MGS: HR 0.02, 95% CI 0.01–0.14; p<0.001; slow 4MGS: 2.76, 95% CI 1.16–6.58; p=0.02). Multivariable models incorporating 4MGS or slow 4MGS had better discrimination for predicting mortality than either the gender, age and lung physiology index or Composite Physiologic Index.In patients with IPF, 4MGS is an independent predictor of all-cause mortality and nonelective hospitalisation.
Soluble PD-L1 is a potential biomarker of cutaneous melanoma aggressiveness and metastasis in obstructive sleep apnoea patients
Authors: Cubillos-Zapata Carolina , Martínez-García Miguel Ángel , Campos-Rodríguez Francisco , Sánchez de la Torre Manuel , Nagore Eduardo , Martorell-Calatayud Antonio , Hernández Blasco Luis , Chiner Vives Eusebi , Abad-Capa Jorge , Montserrat Josep María , Cabriada-Nuño Valentín , Cano-Pumarega Irene , Corral-Peñafiel Jaime , Diaz-Cambriles Trinidad , Mediano Olga , Somoza-González María , Dalmau-Arias Joan , Almendros Isaac , Farré Ramón , López-Collazo Eduardo , Gozal David , García-Río Francisco 
Published: November 2018

Obstructive sleep apnoea (OSA) upregulates the programmed cell death-1 receptor and its ligand (PD-L1) pathway, potentially compromising immunosurveillance. We compared circulating levels of soluble PD-L1 (sPD-L1) in patients with cutaneous melanoma according to the presence and severity of OSA, and evaluated relationships with tumour aggressiveness and invasiveness.In a multicentre observational study, 360 patients with cutaneous melanoma underwent sleep studies, and serum sPD-L1 levels were assayed using ELISA. Cutaneous melanoma aggressiveness indices included mitotic rate, Breslow index, tumour ulceration, Clark level and tumour stage, and sentinel lymph node (SLN) metastasis was recorded as a marker of invasiveness.sPD-L1 levels were higher in severe OSA compared to mild OSA or non-OSA patients. In OSA patients, sPD-L1 levels correlated with Breslow index and were higher in patients with tumour ulceration, advanced primary tumour stages or with locoregional disease. The incorporation of sPD-L1 to the classic risk factors to SLN metastasis led to net improvements in the classification of 27.3%.Thus, sPD-L1 levels are increased in melanoma patients with severe OSA, and, in addition, might serve as a potential biomarker of cutaneous melanoma aggressiveness and invasiveness in this group of subjects.
Post-approval upper airway stimulation predictors of treatment effectiveness in the ADHERE registry
Authors: Heiser Clemens , Steffen Armin , Boon Maurits , Hofauer Benedikt , Doghramji Karl , Maurer Joachim T. , Sommer J. Ulrich , Soose Ryan , Strollo Patrick J. , Schwab Richard , Thaler Erica , Withrow Kirk , Kominsky Alan , Larsen Christopher , Kezirian Eric J. , Hsia Jennifer , Chia Stanley , Harwick John , Strohl Kingman , Mehra Reena 
Published: November 2018

Upper airway stimulation (UAS) has been shown to reduce severity of obstructive sleep apnoea. The aim of this study was to identify predictors of UAS therapy response in an international multicentre registry.Patients who underwent UAS implantation in the United States and Germany were enrolled in an observational registry. Data collected included patient characteristics, apnoea/hypopnoea index (AHI), Epworth sleepiness scale (ESS), objective adherence, adverse events and patient satisfaction measures.Post hocunivariate and multiple logistic regression were performed to evaluate factors associated with treatment success.Between October 2016 and January 2018, 508 participants were enrolled from 14 centres. Median AHI was reduced from 34 to 7 events·h−1, median ESS reduced from 12 to 7 from baseline to final visit at 12-month post-implant. Inpost hocanalyses, for each 1-year increase in age, there was a 4% increase in odds of treatment success. For each 1-unit increase in body mass index (BMI), there was 9% reduced odds of treatment success. In the multivariable model, age persisted in serving as statistically significant predictor of treatment success.In a large multicentre international registry, UAS is an effective treatment option with high patient satisfaction and low adverse events. Increasing age and reduced BMI are predictors of treatment response.
Thrombus aspiration in hyperglycemic ST-elevation myocardial infarction (STEMI) patients: clinical outcomes at 1-year follow-up
Authors: Sardu Celestino , Barbieri Michelangela , Balestrieri Maria Luisa , Siniscalchi Mario , Paolisso Pasquale , Calabrò Paolo , Minicucci Fabio , Signoriello Giuseppe , Portoghese Michele , Mone Pasquale , D’Andrea Davide , Gragnano Felice , Bellis Alessandro , Mauro Ciro , Paolisso Giuseppe , Rizzo Maria Rosaria , Marfella Raffaele 
Published: November 2018

Abstract
Objectives
We evaluate whether the thrombus aspiration (TA) before primary percutaneous coronary intervention (PPCI) may improve STEMI outcomes in hyperglycemic patients.

Background
The management of hyperglycemic patients during STEMI is unclear.

Methods
We undertook an observational cohort study of 3166 first STEMI. Patients were grouped on the basis of whether they received TA or not. Moreover, among these patients we selected a subgroup of STEMI patients with hyperglycemia during the event (glycaemia > 140 mg/dl). The endpoint at 1 year included all-cause mortality, cardiac mortality and re-hospitalization for coronary disease, heart failure and stroke.

Results
One-thousand STEMI patients undergoing PPCI to plus TA (TA-group) and 1504 STEMI patients treated with PPCI alone (no-TA group) completed the study. In overall study-population, Kaplan–Meier-analysis demonstrated no significant difference in mortality rates between patients with and without TA (P = 0.065). After multivariate Cox-analysis (HR: 0.94, 95% CI 0.641–1.383) and the addition of propensity matching (HR: 0.86 95% CI 0.412–1.798) TA was still not associated with decreased mortality. By contrast, in hyperglycemic subgroup STEMI patients (TA-group, n = 331; no-TA group, n = 566), Kaplan–Meier-analysis demonstrated a significantly lower mortality (P = 0.019) in TA-group than the no-TA group. After multivariate Cox-analysis (HR: 0.64, 95% CI 0.379–0.963) and the addition of propensity matching (HR: 0.54, 95% CI 0.294–0.984) TA was still associated with decreased mortality.

Conclusions
TA was not associated with lower mortality in PPCI for STEMI when used in our large all-comer cohort. Conversely, TA during PPCI for STEMI reduces clinical outcomes in hyperglycemic patients.
Trial registration NCT02817542. 25th, June 2016
Identification and immunophenotype of abnormal cells present in focal cortical dysplasia type IIb
Authors: Sousa Gleice K. , Capitelli Caroline S. , Dombroski Thaís C. D. , Zanella César A. B. , Terra Vera C. , Velasco Tonicarlo R. , Machado Hélio R. , Assirati João A. , Carlotti Carlos G. , Alves Vani M. , DaCosta Jaderson Costa , Palmini André L. , Paglioli Eliseu , Sakamoto Americo C. , Spreafico Roberto , Garbelli Rita , Neder Luciano , Martins Antonio R. 
Published: November 2018

Abstract
Background
Focal cortical dysplasias (FCDs) are malformations of cortical development that present cortical dyslamination and abnormal cell morphology and are frequently associated with refractory epilepsy. FCD type IIb presents dysmorphic neurons (DNs) and balloon cells (BCs), which are the hallmarks of this dysplasia. Moreover, hypertrophic neurons (HyNs) may be present in FCD types I, II and III. The objective of this study was to perform a detailed morphology and immunophenotype study of BCs, DNs, and HyNs in a cohort of FCD IIb patients.

Methods
Cortices resected as a treatment for refractory epilepsy from 18 cases of FCD type IIb were analysed using Bielschowsky method and haematoxylin and eosin as routine stains. Immunophenotype was performed using specific antibodies to detect epitopes differentially expressed by abnormal cells.

Results
All cases showed cortical dyslamination, BCs, DNs, and HyNs. No cell layer or column could be identified, except for cortical layer I. Lesions predominated in the frontal cortex (11 cases). DNs were large neurons and presented a clumped and or displaced Nissl substance towards the cell membrane, and a cytoplasm accumulation of neurofilament that displaced the nucleus to the cell periphery, as shown by Bielschowsky staining and immunohistochemistry. HyNs were as large as DNs, but without alterations of Nissl substance or dense neurofilament accumulation, with a central nucleus. BCs were identified as large, oval-shaped and pale eosinophilic cells, which lacked the Nissl substance, and presented an eccentric nucleus. BCs and DNs expressed epitopes of both undifferentiated and mature cells, detected using antibodies against nestin, vimentin, class III β-tubulin, pan-neuronal filaments, neurofilament proteins, β-tubulin and NeuN. Only BCs expressed GFAP.

Conclusion
FCDs present with disorganization of the cerebral cortex architecture, abnormal cell morphology, are frequently associated with refractory epilepsy, and their post-surgical prognosis depends on the type of FCD. The diagnosis of focal cortical dysplasia in a surgical specimen relies on the identification of the abnormal cells present in a dysplastic cortex specimen. The current report contributes to the identification of balloon cells, dysmorphic and hypertrophic neurons in the context of focal cortical dysplasia type IIb.
Body-Weight Fluctuation and Incident Diabetes Mellitus, Cardiovascular Disease, and Mortality: A 16-Year Prospective Cohort Study
Authors: Oh Tae Jung , Moon Jae Hoon , Choi Sung Hee , Lim Soo , Park Kyong Soo , Cho Nam H , Jang Hak Chul 
Published: November 2018

Abstract

Context
Body-weight fluctuation (weight cycling) has been found to be associated with higher mortality and cardiovascular events in patients with coronary artery disease. However, there are very limited data regarding the relationship between body-weight fluctuation and health-related outcomes in the general population.

Methods
We examined whether body-weight fluctuation can associate incident diabetes mellitus and cardiovascular events, and mortality in a Korean population from the Korean Genome and Epidemiology Study. The intraindividual fluctuations of body weight were calculated by average successive variability (ASV); health-related outcomes were collected every 2 years for 16 years in 3,678 participants.

Results
Participants with a high ASV of body weight were more obese and had higher blood pressure and HbA1c levels at baseline than those with a low ASV of body weight. A 1-unit increase in ASV of body weight was associated with increase in mortality (HR, 1.46; 95% CI, 1.32 to 1.62; P &lt; 0.001). However, the association between the ASV of body weight and incident diabetes mellitus seemed to be influenced by baseline body mass index (BMI): negative effect in subjects with BMI &lt;25 kg/m2 (HR, 1.36; 95% CI, 1.11 to 1.65; P = 0.003) and protective effect in those with BMI ≥25 kg/m2 (HR, 0.76; 95% CI, 0.60 to 0.95; P = 0.014). There was no association between the ASV of body weight and cardiovascular event.

Conclusion
Body-weight fluctuation was associated with mortality. In addition, the effect of body-weight fluctuation on incident diabetes mellitus depended on the presence of obesity at baseline.
Abandono e adoção como direito fundamental e adoção internacional como exceção no Nordeste brasileiro
Authors: Costa Gizela Nunes da , Ribeiro José Edmar Da Silva 
Published: November 2018

Este artigo trata do instituto da adoção como direito fundamental e da adoção internacional como exceção, considerando, mais especifi camente, a situação do menor abandonado no Nordeste brasileiro. Para fomentar a metodologia deste estudo, foi realizada a pesquisa bibliográfi ca com análise de obras, da legislação e de dados estatísticos. Aborda os possíveis danos causados pela institucionalização, refl etidos diretamente na sociedade, pois a criança inserida em abrigos sofre com a limitação ou, até mesmo, com a ausência de valores, estímulos, convivência e segurança, sendo, esta última, um direito fundamental do infante. Contextualiza o meio social adverso e hostil da região Nordeste do país. Destaca a condição de penúria das famílias nordestinas, que, muitas vezes, sem alternativa, deixam os fi lhos em portas de residências, abrigos, chegando até a abandoná-los em hospitais ou em postos de saúde. A adoção é entendida como um instituto excepcional para integrar a criança e o adolescente ao convívio familiar estável e seguro e se refere ao conjunto normativo que trata da matéria: Convenção sobre os Direitos da Criança (CDC), Constituição Nacional de 1988 e Estatuto da Criança e do Adolescente (ECA). Conclui-se que a adoção internacional, como exceção, cercada das cautelas legais, oferece a crianças e a adolescentes abandonados um futuro promissor, além de melhores condições de crescimento em comparação aos orfanatos, além de reduzir o tempo de espera para reintegração familiar. Diferentemente dos adotantes brasileiros, mais seletivos, a adoção feita por estrangeiros é livre de preconceitos e sem preferências.
Protocol: New approaches to managing the social deficits of Turner Syndrome using the PEERS program
Authors: Wolstencroft Jeanne , Mandy William , Skuse David 
Published: November 2018

Turner Syndrome (TS) is a sex chromosome aneuploidy (45,X) associated with social skill difficulties. Recent clinical care guidelines recommend that the Program for the Education and Enrichment of Relational Skills (PEERS) social skills intervention programme be trialled in this population. PEERS has been successfully used in adolescents with autism spectrum conditions without intellectual disabilities. The PEERS program will be piloted with adolescents and young women with TS aged 16-20 using an uncontrolled study trial with a multiple-case series design. The program will be delivered face to face and online. The assessment battery is designed to measure social skills comprehensively from diverse informants (parent, teacher young person). It includes measures of social performance, social knowledge and social cognition. Parents and young people taking part in the intervention will also feedback on the acceptability and feasibility of the pilot. The outcomes of this small scale pilot (n=6-10) will be used to adapt the programme based on feedback and estimate the sample for a future randomised controlled trial.
The Ramping Polytope and Cut Generation for the Unit Commitment Problem
Authors: Knueven Ben , Ostrowski Jim , Wang Jianhui 
Published: November 2018

We present a perfect formulation for a single generator in the unit commitment problem, inspired by the dynamic programming approach taken by Frangioni and Gentile. This generator can have characteristics such as ramp-up/ramp-down constraints, time-dependent start-up costs, and start-up/shut-down limits. To develop this perfect formulation, we extend the result of Balas on unions of polyhedra to present a framework allowing for flexible combinations of polyhedra using indicator variables. We use this perfect formulation to create a cut-generating linear program, similar in spirit to lift-and-project cuts, and demonstrate computational efficacy of these cuts in a utility-scale unit commitment problem. The online supplement is available at https://doi.org/10.1287/ijoc.2017.0802 .
A Branch-and-Price Algorithm for Parallel Machine Scheduling Using ZDDs and Generic Branching
Authors: Kowalczyk Daniel , Leus Roel 
Published: November 2018

We study the parallel machine scheduling problem to minimize the sum of the weighted completion times of the jobs to be scheduled (problem Pm∥∑wj Cj in the standard three-field notation). We use the set covering formulation that was introduced by van den Akker et al. [van den Akker J, Hoogeveen J, van de Velde S (1999) Parallel machine scheduling by column generation. Oper. Res. 47(6):862–872.] for this problem, and we improve the computational performance of their branch-and-price (B&P) algorithm by a number of techniques, including a different generic branching scheme, zero-suppressed binary decision diagrams (ZDDs) to solve the pricing problem, dual-price smoothing as a stabilization method, and Farkas pricing to handle infeasibilities. We report computational results that show the effectiveness of the algorithmic enhancements, which depends on the characteristics of the instances. To the best of our knowledge, we are also the first to use ZDDs to solve the pricing problem in a B&P algorithm for a scheduling problem. The online supplement is available at https://doi.org/10.1287/ijoc.2018.0809 .
Treatment of non-idiopathic clubfeet with the Ponseti method: A systematic review
Authors: De Mulder T. , Prinsen S. , Van Campenhout A. 
Published: November 2018

Purpose Although non-idiopathic clubfeet were long thought to be resistant to non-surgical treatment methods, more studies documenting results on treatment of these feet with the Ponseti method are being published. The goal of this systematic review is to summarize current evidence on treatment of non-idiopathic clubfeet using the Ponseti method. Methods PubMed and Limo were searched, reference lists of eligible studies were screened and studies that met the inclusion criteria were included. Data on average number of casts, Achilles tendon tenotomy (ATT), initial correction, recurrence, successful treatment at final follow-up and complications were pooled. The Methodological Index for Non-Randomized Studies was used to assess the methodological quality of the selected studies. Results In all, 11 studies were included, yielding a total of 374 non-idiopathic and 801 idiopathic clubfeet. Non-idiopathic clubfeet required more casts (7.2 versus 5.4) and had a higher rate of ATT (89.4% versus 75.7%). Furthermore, these feet had a higher recurrence rate (43.3% versus 11.5%) and a lower rate of successful treatment at final follow-up (69.3% versus 95.0%). Complications were found in 20.3% of the non-idiopathic cohort. When comparing results between clubfeet associated with myelomeningocele and arthrogryposis, the first group presented with a lower number of casts (5.4 versus 7.2) and a higher rate of successful treatment at final follow-up (81.8% versus 58.2%). Conclusion The Ponseti method is a valuable and non-invasive option in the primary treatment of non-idiopathic clubfeet in young children. Studies with longer follow-up are necessary to evaluate its long-term effect. Level of Evidence Level III – systematic review of Level-III studies. This work meets the requirements of the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).
Study of calcined eggshell as potential catalyst for biodiesel formation using used cooking oil
Authors: Wong Y.C. , Ang R.X. 
Published: November 2018

Abstract
Eggshells were utilized as a cost effective catalyst to assist in biodiesel formation. Eggshells were calcined using different calcination conditions such as temperature and time. The eggshells underwent calcination under 1000 °C in which calcium carbonate was completely converted into calcium oxide under open air conditions. The calcined eggshell catalyst was characterized by X-ray diffraction (XRD). Then the eggshell derived CaO catalyst was subjected to transesterification of used cooking oil (UCO). The parametrics in the transesterification of used cooking oil such as a methanol to oil ratio, weight of catalyst and reaction temperature were evaluated. The optimum result exhibited a 4:1 methanol to oil ratio, 2wt % catalyst, and a 65 °C reaction temperature within two hours. Pure calcined CaO acted as the control of the experiment that was subject to the most optimum eggshell derived catalyst transesterification conditions. The catalytic activity for both the pure calcined CaO and the calcined eggshell derived catalyst were comparable. The biodiesel formation was identified by gas chromatography mass spectrometry (GC-MS).
On the proximal point algorithm and demimetric mappings in CAT(0) spaces
Authors: Aremu Kazeem O. , Izuchukwu Chinedu , Ugwunnadi Godwin C. , Mewomo Oluwatosin T. 
Published: November 2018

Abstract
In this paper, we introduce and study the class of demimetric mappings in CAT(0) spaces.We then propose a modified proximal point algorithm for approximating a common solution of a finite family of minimization problems and fixed point problems in CAT(0) spaces. Furthermore,we establish strong convergence of the proposed algorithm to a common solution of a finite family of minimization problems and fixed point problems for a finite family of demimetric mappings in complete CAT(0) spaces. A numerical example which illustrates the applicability of our proposed algorithm is also given. Our results improve and extend some recent results in the literature.
Loess documentary sites and their potential for geotourism in Lower Silesia (Poland)
Authors: Jary Zdzisław , Owczarek Piotr , Ryzner Kamila , Widawski Krzysztof , Krawczyk Marcin , Krzyszkowski Dariusz , Skurzyński Jacek 
Published: November 2018

Abstract
The presented article fits into the subject of using the geotourist potential in the development of tourism in the region on the example of Lower Silesia voivodship. The main purpose of the article is actually the presentation of the potential of documentary sites, one of the abiotic forms of nature protection functioning in Poland, in the context of geoprotection and as geotourist attraction. Using the method of sightseeing inventory, a review of forms of nature protection has been carried out. Although “Soft” Rock Geosites are not excessively popular and appreciated, they are significant element of Quaternary palaeoclimatic and palaeoenvironmental archive and can provide interpretative facilities and services not only for geoscientists but also for constantly expanding group of conscious tourists. As a consequence of lithological and chronological research, two Late Pleistocene loess-soil sequences from Lower Silesia have been chosen: "Loess of Vine Mountain" - documentary site established in 2016 in Trzebnica and loess-soil sequence in Biały Kościół. After a detailed presentation of the sections, educational values were indicated, which should be promoted. Cultural values occurring in the vicinity of documentation sites are also presented. Taking into account the threats to the proper development of documentation sites, which were indicated in the article, solutions were proposed that would allow the sustainable development of geotourist resources of the loess.