bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide identification and expression analysis of DNA demethylase family in cotton
Authors: YANG Xiaomin , LU Xuke , CHEN Xiugui , WANG Delong , WANG Junjuan , WANG Shuai , GUO Lixue , CHEN Chao , WANG Xiaoge , WANG Xinlei , YE Wuwei 
Published: October 2019

Abstract

Background
DNA methylation is an important epigenetic factor that maintains and regulates gene expression. The mode and level of DNA methylation depend on the roles of DNA methyltransferase and demethylase, while DNA demethylase plays a key role in the process of DNA demethylation. The results showed that the plant’s DNA demethylase all contained conserved DNA glycosidase domain. This study identified the cotton DNA demethylase gene family and analyzed it using bioinformatics methods to lay the foundation for further study of cotton demethylase gene function.

Results
This study used genomic information from diploid Gossypium raimondii JGI (D), Gossypium arboreum L. CRI (A), Gossypium hirsutum L. JGI (AD1) and Gossypium barbadebse L. NAU (AD2) to Arabidopsis thaliana. Using DNA demethylase genes sequence of Arabidopsis as reference, 25 DNA demethylase genes were identified in cotton by BLAST analysis. There are 4 genes in the genome D, 5 genes in the genome A, 10 genes in the genome AD1, and 6 genes in the genome AD2. The gene structure and evolution were analyzed by bioinformatics, and the expression patterns of DNA demethylase gene family in Gossypium hirsutum L. were analyzed. From the phylogenetic tree analysis, the DNA demethylase gene family of cotton can be divided into four subfamilies: REPRESSOR of SILENCING 1 (ROS1), DEMETER (DME), DEMETER-LIKE 2 (DML2), and DEMETER-LIKE3 (DML3). The sequence similarity of DNA demethylase genes in the same species was higher, and the genetic relationship was also relatively close. Analysis of the gene structure revealed that the DNA demethylase gene family members of the four subfamilies varied greatly. Among them, the number of introns of ROS1 and DME subfamily was larger, and the gene structure was more complex. For the analysis of the conserved domain, it was known that the DNA demethylase family gene member has an endonuclease III (ENDO3c) domain.

Conclusion
The genes of the DNA demethylase family are distributed differently in different cotton species, and the gene structure is very different. High expression of ROS1 genes in cotton were under abiotic stress. The expression levels of ROS1 genes were higher during the formation of cotton ovule. The transcription levels of ROS1 family genes were higher during cotton fiber development.
A Systematic Study on the Double-Layered Photosensitizing Dye Structure on the Surface of Pt-Cocatalyst-Loaded TiO2 Nanoparticles
Authors: Yoshimura Nobutaka , Kobayashi Atsushi , Yoshida Masaki , Kato Masako 
Published: October 2019

Abstract
We have systematically prepared three kinds of photosensitizing (PS) double layers on the surface of Pt-cocatalyst-loaded TiO2 (Pt-TiO2) nanoparticles by using four different phosphonate-functionalized Ru(II) polypyridine photosensitizers (Ru) and Zr4+ cation linkers to improve the photo-induced separation efficiency at the double-PS-layer and semiconductor interface. All three nanoparticles with double-PS-layer structure (Ru-Zr-Ru@Pt-TiO2) exhibited remarkably higher photocatalytic H2 evolution activity than that of single-PS-layer nanoparticles, Ru@Pt-TiO2 in low sacrificial electron donating (SED) l-ascorbic acid solution. The fine-tuning of emission energy of Ru(II) PS dye at the outer surface of Ru-Zr-Ru@Pt-TiO2 nanoparticle revealed that photoexcitation energy transfer from outer to inner Ru(II) PS dyes give a positive effect on the photocatalytic activity especially in the low SED concentration.
A Prospective Cohort Study of Collegiate Fencing Injuries
Authors: Walrod Bryant , Turner Wil , Hartz Clinton 
Published: October 2019

Abstract
Data with respect to collegiate fencing injuries are very limited. We performed a prospective cohort study of a college fencing team to analyze the rates and types of injuries that occurred to this team over the course of a year. We noted that the injury rate was low, with 2.43 injuries per 1000 athlete exposures. We also noted that 75% of those injured had a time loss of less than 2 wk. A large percentage of our injuries (88%) were musculoskeletal in nature. There were equal numbers of acute and chronic injuries. Men and women had a similar rate of injury. In our study population, we noted that most of the injuries occurred in practice over competition (87.5% vs 12.5%, respectively). We compared the data from a small subset population with the current evidence published with respect to fencing injuries. We noted some similarities and also some differences when comparing certain populations.
Can the lower rate of CT- or MRI-related adverse drug reactions to contrast media due to stricter limitations on patients undergoing contrast-enhanced CT or MRI?
Authors: Maeda Takahiro , Oda Masafumi , Kito Shinji , Tanaka Tatsurou , Wakasugi-Sato Nao , Matsumoto-Takeda Shinobu , Joujima Takaaki , Miyamura Yuichi , Kiyota Koichi , Tsutsumi Kensuke , Morimoto Yasuhiro 
Published: October 2019

Objective: The aim of this study was to examine whether a decreased occurrence rate of adverse drug reactions (ADRs) to contrast media in contrast-enhanced CT and MRI was attributable to appropriate criteria for patients with some diseases. A secondary aim was to elucidate safety profiles for contrast media and factors influencing the occurrence of ADRs. Methods: Clinical data of patients who underwent contrast-enhanced CT (5576 cases) or MRI (3357 cases) were retrospectively analyzed to evaluate rates of ADRs to contrast media, symptoms of ADRs, treatments for ADRs, and differences in medical history, blood test results, and other factors between patients with and without ADRs in a dental hospital. Results: The rate of ADRs to contrast media was 0.54% for CT and 0.09% for MRI. The most frequent ADRs in contrast-enhanced CT or MRI were nausea and vomiting as physiologic reactions. Two serious reactions were seen for CT, but none for MRI. Significant differences between patients with and without ADRs were seen in liver function according to blood tests for CT, and in digestive disorders elicited from medical interviews for MRI. Conclusion: The lower occurrence rate of ADRs to contrast media in dental hospitals could be due to the adoption of appropriate criteria for patients with some diseases undergoing enhanced CT or MRI. Complete suppression of ADRs to contrast media for CT or MRI is unrealistic, so attention is warranted for patients with decreased liver function when performing enhanced CT, and for patients with digestive disorders when performing enhanced MRI.
New Estonian records: Lichenicolous fungi
Authors: Suija Ave 
Published: October 2019

Lichenodiplis lichenicola Dyko & D. Hawksw, the third Lichenodiplis (Chaetothyriales, Eurotiomycetes) species found from Estonia besides L. lecanorae and L. pertusariicola (syn. Laeviomyces pertusariicola).
Cidadania na cidade: escolhas para o desenho institucional participativo no Plano Diretor do Município de Nova Friburgo de 2007
Authors: Assis Vívian De , Fauth Gabriela Alves , Cavallazzi Rosangela Lunardelli 
Published: October 2019

Este artigo tem por objeto analisar as escolhas de desenhos institucionais participativos, segundo o método de caso referência, a partir da experiência da elaboração do Plano Diretor de Nova Friburgo sancionado em 2007 e premiado entre iniciativas de Melhores Práticas em Gestão Local 2007/2008 pela CAIXA devido ao seu caráter participativo. Adota-se como referencial teórico as escolhas em desenho institucional participativo para minipúblicos elaborada por Archon Fung e as análises das instituições participativas brasileiras de Leonardo Avritzer. A hipótese desta pesquisa aponta para as especificidades do processo de elaboração do Plano Diretor de Nova Friburgo em relação aos demais Planos Diretores Municipais brasileiros elaborados à época em virtude da ampla participação na elaboração da metodologia, etapa em regra construída por setores técnicos e pelas consultorias. Em relação aos limites, o estudo observa a gradativa ineficácia dos limites de desempenho desse instrumento à ação política pela desarticulação de seu desenho institucional pelo processo político inerente, logo após a sanção do referido Plano Diretor. Bem como em razão da ausência de regulamentação das esferas participativas previstas no mesmo, que dariam continuidade à ação política, tornando a participação em uma substantiva política de governança.
Observation of inadvertent tube loss in ICU: effect of nasal bridles
Authors: Allan Kaylee , Taylor Stephen , Clemente Rowan , Toher Deirdre 
Published: October 2019

Background: safe placement and securement of feeding tubes are essential to establishing early enteral nutrition. Nasogastric or nasojejunal feeding tubes are often inadvertently removed, and using a nasal bridle can reduce the number of tube replacements required. Aim: to review current nasal bridle practices on one intensive care unit. Over a 3-month period, nasal bridle use was recorded to measure unintentional tube loss and tube duration (the time a tube remained in situ). Method: an observational service evaluation. Findings: 109 patients were recruited; 205 tubes were passed and 77 bridles were inserted, with 42% (n=46) of the bridles placed on day 1. Tubes secured with tape were more likely to be dislodged than tubes secured with a bridle, P=0.0001. Duration of tubes remaining in situ was significantly longer in patients who had a bridle fitted on day 1, P=0.0001 compared with tubes secured with tape. Conclusion: securing a tube with a nasal bridle from day 1 is independently associated with reduced tube loss, increased duration of tube use, and likelihood that the tube would reach redundancy when it was no longer required.
OPTUNS: Optical intra-data center network architecture and prototype testbed for a 5G edge cloud [Invited]
Authors: Yuang Maria , Tien Po-Lung , Ruan Wei-Zhang , Lin Tien-Chien , Wen Shao-Chun , Tseng Po-Jen , Lin Che-Chang , Chen Ching-Nien , Chen Chun-Ting , Luo Yi-An , Tsai Meng-Ru , Zhong Shan 
Published: October 2019

An edge data center (EDC) network infrastructure is required to flexibly deliver massive bandwidth and ultralow latency for a 5G edge cloud. Existing electrical-switching-based infrastructure, however, has been shown incapable of meeting such requirements. In this paper, we present an EDC network architecture and prototype testbed, referred to as the intelligence-defined optical tunnel network system (OPTUNS). OPTUNS consists of a set of optical switching subsystems that operate collectively to facilitate packet transport through logical wavelength-based optical tunnels. These optical tunnels are governed by a software-defined-networking-based intelligent tunnel control system, in a proactive manner. As such, optical tunnels are always made available whenever needed. In essence, OPTUNS boasts several crucial features, including high scalability, massive wavelength reuse (yielding high bandwidth), proactive optical tunnel control (yielding ultralow latency), and fault tolerance. We have built an OPTUNS testbed, including 30 optical switching subsystem prototypes, that interconnect a total of 25 racks (400 servers). Benchmarking results show that OPTUNS achieves 82.6% power saving compared with electrical spine-leaf networks. Further, our NetPipe-based experimental results show that OPTUNS invariably achieves mean and p99 end-to-end latencies of less than 17 µs, regardless of traffic load and locality.
Eine merkwürdige griechische Randnotiz Überlegungen zum koptischen Kodexblatt Paris BNCopte164 II fol. 16m recto
Authors: Sänger-Böhm Kerstin 
Published: October 2019

Abstract
A papyrus codex which contained the Sahidic version of the Gospel of John exhibits a highly interesting “marginal note”. On the bottom margin of one page (Paris BNCopte164 II fol. 16m) one finds traces of the beginning of five lines written in Greek in a cursive hand usually used in documentary papyri. A closer look at the Greek cursive suggests that these lines originally belonged to the text of a fifth-century protokollon.
Die koptischen Papyri aus dem „Ankauf aus Edfû (Apollinopolis magna) vom Jahre 1911“ der Jenaer Papyrussammlung (P.Ien. Inv. 446–453)
Authors: Richter Tonio Sebastian 
Published: October 2019

Abstract
The Jena papyrus collection contains eight Coptic items (P.Ien. Inv. 446-453) belonging to a larger assemblage of Greek, Demotic, Coptic and Arabic papyri (P.Ien. Inv. 259-472) which Fritz Uebel described as „the Edfu purchase of the year 1911“. Uebel took the provable provenance from Edfu of a number of Ptolemaic Greek papyri to hold for the assemblage as a whole. Of five less fragmentary Coptic papyri from this assemblage published in this article, three at least are unlikely to come from Edfu. The Coptic part of the „Edfu purchase of the year 1911“ thus challenges Uebel’s generalising conclusion.
Examining the Effectiveness of a PETTLEP Imagery Intervention on the Football Skill Performance of Novice Athletes
Authors: norouzi ebrahim , Norouzi Seyed Hossini Rasool , Afroozeh Mohammad Sadegh , Vaezmosavi Mohammad , Gerber Markus , Puehse Uwe , Brand Serge 
Published: October 2019

Abstract
While imagery techniques have been included in most psychological skills training programs for elite athletes, only few studies have investigated the effects of various components of imagery such as physical, environmental, tasking, timing, learning, emotion, and perspective (PETTLEP) in the context of motor learning among novice athletes. We tested whether external PETTLEP imagery and internal PETTLEP imagery were able to improve football pass skill acquisition more than a control condition, and thus enhance motor learning among novice players. A total of 45 male adolescent novice players (M = 14.65 years, SD = 1.34) were randomly assigned to the following three study conditions: external PETTLEP imagery, internal PETTLEP imagery, and a control condition. At the beginning, and four weeks after randomization, football pass skill performance was measured objectively. Football pass skill performance improved over time in all groups, but more so in the external PETTLEP imagery and internal PETTLEP imagery condition compared to the control condition. At the retention-test, the highest pass skill performance was observed in the external PETTLEP imagery condition. The findings suggest that among adolescent novice football players, compared to internal PETTLEP imagery and a control condition, external PETTLEP imagery led to the highest improvement in football pass skill performance. The PETTLEP imagery thus appears to have the potential to enhance the gross motor skills acquisition of novice athletes who seek to become elite players.
Telomerase Reverse Transcriptase and p53 Regulate Mammalian Peripheral Nervous System and CNS Axon Regeneration Downstream of c-Myc
Authors: Ma Jin-Jin , Ju Xin , Xu Ren-Jie , Wang Wei-Hua , Luo Zong-Ping , Liu Chang-Mei , Yang Lei , Li Bin , Chen Jian-Quan , Meng Bin , Yang Hui-Lin , Zhou Feng-Quan , Saijilafu  
Published: October 2019

Although several genes have been identified to promote axon regeneration in the CNS, our understanding of the molecular mechanisms by which mammalian axon regeneration is regulated is still limited and fragmented. Here by using female mouse sensory axon and optic nerve regeneration as model systems, we reveal an unexpected role of telomerase reverse transcriptase (TERT) in regulation of axon regeneration. We also provide evidence that TERT and p53 act downstream of c-Myc to control sensory axon regeneration. More importantly, overexpression of p53 in sensory neurons and retinal ganglion cells is sufficient to promote sensory axon and optic never regeneration, respectively. The study reveals a novel c-Myc-TERT-p53 signaling pathway, expanding horizons for novel approaches promoting CNS axon regeneration.SIGNIFICANCE STATEMENTDespite significant progress during the past decade, our understanding of the molecular mechanisms by which mammalian CNS axon regeneration is regulated is still fragmented. By using sensory axon and optic nerve regeneration as model systems, the study revealed an unexpected role of telomerase reverse transcriptase (TERT) in regulation of axon regeneration. The results also delineated a c-Myc-TERT-p53 pathway in controlling axon growth. Last, our results demonstrated that p53 alone was sufficient to promote sensory axon and optic nerve regenerationin vivo. Collectively, the study not only revealed a new mechanisms underlying mammalian axon regeneration, but also expanded the pool of potential targets that can be manipulated to enhance CNS axon regeneration.
Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections
Authors: Mo Mingshu , Eyo Ukpong B. , Xie Manling , Peng Jiyun , Bosco Dale B. , Umpierre Anthony D. , Zhu Xiaoqin , Tian Dai-Shi , Xu Pingyi , Wu Long-Jun 
Published: October 2019

Seizures are common in humans with various etiologies ranging from congenital aberrations to acute injuries that alter the normal balance of brain excitation and inhibition. A notable consequence of seizures is the induction of aberrant neurogenesis and increased immature neuronal projections. However, regulatory mechanisms governing these features during epilepsy development are not fully understood. Recent studies show that microglia, the brain's resident immune cell, contribute to normal neurogenesis and regulate seizure phenotypes. However, the role of microglia in aberrant neurogenic seizure contexts has not been adequately investigated. To address this question, we coupled the intracerebroventricular kainic acid model with current pharmacogenetic approaches to eliminate microglia in male mice. We show that microglia promote seizure-induced neurogenesis and subsequent seizure-induced immature neuronal projections above and below the pyramidal neurons between the DG and the CA3 regions. Furthermore, we identify microglial P2Y12 receptors (P2Y12R) as a participant in this neurogenic process. Together, our results implicate microglial P2Y12R signaling in epileptogenesis and provide further evidence for targeting microglia in general and microglial P2Y12R in specific to ameliorate proepileptogenic processes.SIGNIFICANCE STATEMENTEpileptogenesis is a process by which the brain develops epilepsy. Several processes have been identified that confer the brain with such epileptic characteristics, including aberrant neurogenesis and increased immature neuronal projections. Understanding the mechanisms that promote such changes is critical in developing therapies to adequately restrain epileptogenesis. We investigated the role of purinergic P2Y12 receptors selectively expressed by microglia, the resident brain immune cells. We report, for the first time, that microglia in general and microglial P2Y12 receptors in specific promote both aberrant neurogenesis and increased immature neuronal projections. These results indicate that microglia enhance epileptogenesis by promoting these processes and suggest that targeting this immune axis could be a novel therapeutic strategy in the clinic.
The Drosophila CPEB Protein Orb Specifies Oocyte Fate by a 3′UTR-Dependent Autoregulatory Loop
Authors: Barr Justinn , Gilmutdinov Rudolf , Wang Linus , Shidlovskii Yulii , Schedl Paul 
Published: October 2019

Abstract
orb encodes one of the two fly CPEB proteins. These widely conserved proteins bind to the 3′UTRs of target messenger RNAs (mRNAs) and activate or repress their translation. We show here that a positive autoregulatory loop driven by the orb gene propels the specification of oocyte identity in Drosophila egg chambers. Oocyte fate specification is mediated by a 3′UTR-dependent mechanism that concentrates orb mRNAs and proteins in one of the two pro-oocytes in the 16-cell germline cyst. When the orb 3′UTR is deleted, orb mRNA and protein fail to localize and all 16 cells become nurse cells. In wild type, the oocyte is specified when orb and other gene products concentrate in a single cell in region 2b of the germarium. A partially functional orb 3′UTR replacement delays oocyte specification until the egg chambers reach stage 2 of oogenesis. Before this point, orb mRNA and protein are unlocalized, as are other markers of oocyte identity, and the oocyte is not specified. After stage 2, ∼50% of the chambers successfully localize orb in a single cell, and this cell assumes oocyte identity. In the remaining chambers, the orb autoregulatory loop is not activated and no oocyte is formed. Finally, maintenance of oocyte identity requires continuous orb activity.
Model Autoregressive dengan Pendekatan Conditional Maximum Likelihood Untuk Prediksi Harga Saham
Authors: Rahmadayanti Cipta , Rabbani Hasbi , Rohmawati Aniq Atiqi 
Published: October 2019

Jual beli saham merupakan salah satu bentuk investasi yang menjanjikan para investor, investasi berkaitan dengan return atau keuntungan yang didapatkan oleh suatu investor atas suatu investasi yang dilakukan terhadap saham tertentu. Untuk mendapatkan nilai return pada beberapa periode kedepan dapat dilakukan prediksi, pada dasarnya prediksi dapat dilakukan dengan menggunakan beberapa metode, namun dengan menggunakan model time series diharapkan menghasilkan prediksi yang baik karna karakteristik dari data saham merupakan data time series yang bergerak kontinu terhadap waktu. Pada penelitian ini digunakan model time series Autoregressive (AR) dengan pendekatan Conditional Maximum Likelihood untuk memprediksi nilai return serta dapat melihat pergerakan harga saham. Nilai parameter yang penting pada model Autoregressive orde 1 adalah . Hasil penaksiran parameter dengan Conditional Maximum Likelihood digunakan untuk memperoleh nilai hasil prediksi. Berdasarkan hasil analisis, model Autoregressive dengan pendekatan Conditional Maximum Likelihood adalah model yang baik untuk memprediksi return dan harga saham NASDAQ dengan RMSE sebesar 0,0002578. Berdasarkan hasil prediksi model AR(1), maka para investor dapat membuat strategi untuk berinvestasi pada indek saham NASDAQ agar dapat menghasilkan keuntungan.
Seismicity Monitoring in North-Central New Mexico by the Los Alamos Seismic Network
Authors: House Leigh , Roberts Peter 
Published: October 2019

AbstractThe first seismic stations of the Los Alamos Seismic Network (LASN) were installed in 1973, as a part of research on monitoring of nuclear testing. The extent of the network rapidly expanded by the late 1970s. By the middle 1980s, spatial coverage of the network was drastically reduced, due to a loss of funding. Since then, however, it has been possible to expand the coverage of the network with additional stations and to slowly upgrade network equipment to match contemporary instrument standards. These improvements will make it possible to keep recording the network’s data and to initiate real-time exchange of data with other institutions to improve earthquake monitoring throughout New Mexico and neighboring states. During more than 40 yr of operation, the network has provided a slow but steady increase in the volume of earthquake seismograms available to study seismicity and tectonics in north-central New Mexico. The current network covers an area from the Valles Caldera on the west, to within the Rio Grande rift on the east. LASN has yielded locations for about 900 earthquakes in north-central New Mexico between 1973 and 2013 (the most recent locations available). Epicenters of these have a complex pattern, with some that can be attributed to the deformation of the rift, though most are spread in areas west of the rift. A lack of seismicity in and near the Valles Caldera reinforces an earlier observation, based on far fewer earthquakes, which first called attention to this paucity of seismicity and attributed it to ductile deformation resulting from elevated crustal temperatures.