bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction between curvature-driven width oscillations and channel curvature in evolving meander bends
Authors: Monegaglia F. , Tubino M. , Zolezzi G. 
Published: August 2019

We study the morphodynamics of channel width oscillations associated with the planform development of river meander bends. With this aim we develop a novel planform evolution model, based on the framework of the classical bend theory of river meanders by Ikedaet al. (J. Fluid Mech., vol. 112, 1981), that accounts for local width changes over space and time, tied to the local hydro-morphodynamics through a two-way feedback process. We focus our attention on ‘autogenic’ width variations, which are forced by flow nonlinearities driven by channel curvature dynamics. Under the assumption of regular, sinusoidal width and curvature oscillations, we obtain a set of ordinary differential equations, formally identical to those presented by Seminaraet al. (J. Fluid Mech., vol. 438, 2001, pp. 213–230), with an additional equation for the longitudinal oscillation of the channel width. The proposed approach gives insight into the interaction between autogenic width variations and curvature in meander development and between forcing and damping effects in the formation of width variations. Model outcomes suggest that autogenic width oscillations mainly determine wider-at-inflection meandering river patterns, and affect their planform development particularly at super-resonant aspect ratios, where the width oscillation reaches its maximum and reduces meander sinuosity and lateral floodplain size. The coevolution of autogenic width oscillation and curvature occurs through temporal hysteresis cycles, whereby the peak in channel curvature lags behind that of width oscillation. Width oscillation amplitudes predicted by the model are consistent with those extracted from remotely sensed data.
Droplets in homogeneous shear turbulence
Authors: Rosti Marco E. , Ge Zhouyang , Jain Suhas S. , Dodd Michael S. , Brandt Luca 
Published: August 2019

We simulate the flow of two immiscible and incompressible fluids separated by an interface in a homogeneous turbulent shear flow at a shear Reynolds number equal to 15 200. The viscosity and density of the two fluids are equal, and various surface tensions and initial droplet diameters are considered in the present study. We show that the two-phase flow reaches a statistically stationary turbulent state sustained by a non-zero mean turbulent production rate due to the presence of the mean shear. Compared to single-phase flow, we find that the resulting steady-state conditions exhibit reduced Taylor-microscale Reynolds numbers owing to the presence of the dispersed phase, which acts as a sink of turbulent kinetic energy for the carrier fluid. At steady state, the mean power of surface tension is zero and the turbulent production rate is in balance with the turbulent dissipation rate, with their values being larger than in the reference single-phase case. The interface modifies the energy spectrum by introducing energy at small scales, with the difference from the single-phase case reducing as the Weber number increases. This is caused by both the number of droplets in the domain and the total surface area increasing monotonically with the Weber number. This reflects also in the droplet size distribution, which changes with the Weber number, with the peak of the distribution moving to smaller sizes as the Weber number increases. We show that the Hinze estimate for the maximum droplet size, obtained considering break-up in homogeneous isotropic turbulence, provides an excellent estimate notwithstanding the action of significant coalescence and the presence of a mean shear.
Novel insights for SREBP-1 as a key transcription factor in regulating lipogenesis in a freshwater teleost, grass carp Ctenopharyngodon idella
Authors: Xu Yi-Huan , Tan Xiao-Ying , Xu Yi-Chuang , Zhao Tao , Zhang Li-Han , Luo Zhi 
Published: August 2019

AbstractDisturbances in lipid metabolism are at the core of several health issues facing modern society, including fatty liver and obesity. The sterol regulatory element-binding protein 1 (SREBP-1) is one important transcription factor regulating lipid metabolism, but the relevant mechanism still remains unknown. The present study determined the transcriptional regulation of SREBP-1 and its target genes (including acetyl-CoA carboxylase α (accα), fatty acid synthase (fas) and stearoyl-CoA desaturase 1 (scd1)) in a freshwater teleost, grass carp Ctenopharyngodon idella. We cloned and characterised the 1988 bp, 2043 bp, 1632 bp and 1889 bp sequences of srebp-1, accα, scd1 and fas promoters, respectively. A cluster of putative binding sites of transcription factors, such as specific protein, yin yang 1, nuclear factor Y, sterol response elements (SRE) and enhancer box (E-box) element, were predicted on their promoter regions. Overexpression of nSREBP-1 reduced srebp-1 promoter activity, increased scd1 and fas promoter activity but did not influence accα promoter activity. The site-mutation and electrophoretic mobility shift assay analysis indicated that srebp-1, fas and scd1 promoters, but not accα promoter, possessed SRE. In Ctenopharyngodon idella kidney (CIK) cells of grass carp, nSREBP-1 overexpression significantly reduced srebp-1 mRNA expression and up-regulated miR-29 mRNA expression. The 3′UTR of srebp-1 possessed the potential miR-29 binding site and miR-29 up-regulated the luciferase activity of srebp-1 3′UTR and srebp-1 mRNA expression, implying a self-activating loop of SREBP-1 and miR-29 in grass carp. Based on the above-mentioned results, we found two novel transcriptional mechanisms for SREBP-1 in grass carp: (1) the auto-regulation sited on the SREBP-1 promoter regions was suppressive and (2) there was a self-activating loop of SREBP-1 and miR-29.
Visceral larva migrans detection using PCR–RFLP in BALB/c mice infected withToxocara canis
Authors: Özbakış G. , Doğanay A. 
Published: August 2019

AbstractToxocara canisis an important zoonotic roundworm distributed worldwide. The infective larvae ofT. canisare one of the causes of visceral larva migrans (VLM), a clinical syndrome in humans. Diagnosing VLM is difficult, and the differential diagnosis of the larval development stage is limited. Therefore, this experimental research aimed to diagnoseT. canislarvae using a molecular method, not only in liver tissue, which is the most commonly affected tissue, but also in the limb muscles, lungs and brain tissues. For this purpose, 24 BALB/c mice were infected with 1000 embryonatedT. caniseggs. Necropsies were performed on the second, fourth, seventh and 14th days post-infection. While a part of the samples were digested with pepsin-HCl, the molecular method was used for the remainder of the samples to replicate the mitochondrial DNA adenosine triphosphate (ATP) synthase subunit-6 gene region ofT. canis. BbsI, a restriction endonuclease, was used to determine the specificity of the amplicons obtained from Polymerase chain reaction (PCR). The detection limit for embryonated eggs was recorded. The PCR results showed that the sensitivity of the PCR analysis was 83.3% in the liver (with 88.8% accuracy), 87.5% in the lungs (with 91.6% accuracy) and 75.0% in the brain, forelimb and hindlimb muscles (with 83.3% accuracy). In all tissues, the test specificity was determined to be 100%. In this study, the molecular method was applied to only experimentally infected BALB/c mice tissues; thus, it is suggested that it can be also employed in different paratenic hosts and materials possibly infected withT. canis.
Drug repurposing for the treatment of alveolar echinococcosis: in vitro and in vivo effects of silica nanoparticles modified with dichlorophen
Authors: Fabbri Julia , Pensel Patricia E. , Albani Clara M. , Arce Valeria B. , Mártire Daniel O. , Elissondo María C. 
Published: August 2019

AbstractAlveolar echinococcosis is a neglected parasitic zoonosis caused by the metacestode Echinococcus multilocularis, which grows as a malignant tumour-like infection in the liver of humans. Albendazole (ABZ) is the antiparasitic drug of choice for the treatment of the disease. However, its effectiveness is low, due to its poor absorption from the gastro-intestinal tract. It is also parasitostatic and in some cases produces side-effects. Therefore, an alternative to the treatment of this severe human disease is necessary. In this context, the repositioning of drugs combined with nanotechnology to improve the bioavailability of drugs emerges as a useful, fast and inexpensive tool for the treatment of neglected diseases. The in vitro and in vivo efficacy of dichlorophen (DCP), an antiparasitic agent for intestinal parasites, and silica nanoparticles modified with DCP (NP-DCP) was evaluated against E. multilocularis larval stage. Both formulations showed a time and dose-dependent in vitro effect against protoscoleces. The NP-DCP had a greater in vitro efficacy than the drug alone or ABZ. In vivo studies demonstrated that the NP-DCP (4 mg kg−1) had similar efficacy to ABZ (25 mg kg−1) and greater activity than the free DCP. Therefore, the repurposing of DCP combined with silica nanoparticles could be an alternative for the treatment of echinococcosis.
Indirect costs associated with deaths of children aged 0–14 years from measles in a weak health system and conflict and fragile zone: the case of Somalia
Authors: Da'ar Omar B. 
Published: August 2019

AbstractThis study recognises periodic outbreaks of measles continue to affect conflict and fragile zones in the least developed countries. This study set out to provide evidence for the indirect costs or economic loss associated with measles-related deaths among children aged 0–14 years in Somalia. Using epidemiologic and economic data, the indirect cost was calculated based on the framework of the World Health Organisation guide of identifying the economic consequences of disease and injury. The baseline indirect cost was computed as the product of discounted future productive years of life lost (PYLL), non-health gross domestic product per capita (NHGDPPC) and the estimated total measles deaths (ETMD). The model was adjusted for conflict and fragility conditions and further extension considered a finite and stable upper limit growth of the instability-adjusted NHGDPPC. To discount future costs, a rate of 3% was applied. Using a ±20% variability assumption of the epidemiologic and economic factor inputs, a sensitivity analysis was conducted to account for uncertainty. In 2015 values, the ETMD of 3723 measles deaths of children aged 0–14 years could decrease non-health GDP of the country by $23.46 million, a potential loss of $6303 per death over the discounted PYLL. The loss would increase by 5.3% when adjusted for conflict and fragility conditions. Assuming growth, the future adjusted loss is expected to be $35.91 million in 2015 values. Girl-child deaths accounted for 51.2% of the burden. Results are robust to the variations in the model inputs, although sensitivity analyses suggest the proportion of total measles deaths and the discount rate accounted for greater uncertainty of the loss than do the proportion of growth and instability assumption. Conflict and fragility accounted for the least uncertainty, perhaps confirming their relative perpetuity in Somalia. Results show significant indirect cost related to measles deaths of children, exacerbated by conflict and fragility. This is an economic burden, but one which the health system, policy-makers, government and other stakeholders should be prepared to colossally discount by collectively taking measles surveillance and security measures now to reduce further deaths in the future.
Association between dietary patterns and overweight risk among Malaysian adults: evidence from nationally representative surveys
Authors: Shyam Sangeetha , Khor Geok-Lin , Ambak Rashidah , Mahadir Balkish , Hasnan Mohamad , Ambu Stephen , Chu Wan-Loy , Aris Tahir 
Published: August 2019

AbstractObjective:To investigate the association between dietary patterns (DP) and overweight risk in the Malaysian Adult Nutrition Surveys (MANS) of 2003 and 2014.Design:DP were derived from the MANS FFQ using principal component analysis. The cross-sectional association of the derived DP with prevalence of overweight was analysed.Setting:Malaysia.Participants:Nationally representative sample of Malaysian adults from MANS (2003, n 6928; 2014, n 3000).Results:Three major DP were identified for both years. These were ‘Traditional’ (fish, eggs, local cakes), ‘Western’ (fast foods, meat, carbonated beverages) and ‘Mixed’ (ready-to-eat cereals, bread, vegetables). A fourth DP was generated in 2003, ‘Flatbread & Beverages’ (flatbread, creamer, malted beverages), and 2014, ‘Noodles & Meat’ (noodles, meat, eggs). These DP accounted for 25·6 and 26·6 % of DP variations in 2003 and 2014, respectively. For both years, Traditional DP was significantly associated with rural households, lower income, men and Malay ethnicity, while Western DP was associated with younger age and higher income. Mixed DP was positively associated with women and higher income. None of the DP showed positive association with overweight risk, except for reduced adjusted odds of overweight with adherence to Traditional DP in 2003.Conclusions:Overweight could not be attributed to adherence to a single dietary pattern among Malaysian adults. This may be due to the constantly morphing dietary landscape in Malaysia, especially in urban areas, given the ease of availability and relative affordability of multi-ethnic and international foods. Timely surveys are recommended to monitor implications of these changes.
Geologic Investigation of Deep Simple Craters in the Lunar Simple‐to‐Complex Transition
Authors: Chandnani M. , Herrick R. R. , Kramer G. Y. 
Published: August 2019

AbstractFrom a group of well‐preserved lunar simple craters in the 15‐ to 20‐km diameter range and with the help of Lunar Orbiter Laser Altimeter topography data, we identified a subset of eight deep craters (depth/diameter ratio > 0.20). These craters are in the regions around the mare‐highlands boundaries, which are characterized as having the highest porosity on the lunar surface. To understand the cratering mechanics behind the formation of these craters, a geologic investigation of the terrains of these craters was performed. We evaluated the depth/diameter ratios of smaller simple craters surrounding several 15‐ to 20‐km diameter craters, analyzed the morphometry of the craters, and visually examined the cavities using multiple data sets. We conclude that deep transient cavities were formed from compaction of porous target material. The result was a deeper than normal simple crater without an identifiable increase in the volume of excavated material, as inferred from the craters' rim heights and shapes. While all of these craters formed in areas of high porosity, not all craters in high‐porosity regions are deep. It may be that some unusual impactor property is also required to produce a deep crater, such as a high velocity impact, a near‐vertical impact, or a dense impactor that yielded a large penetration depth.
Jovian Injections Observed at High Latitude
Authors: Haggerty D. K. , Mauk B. H. , Paranicas C. P. , Clark G. , Kollmann P. , Rymer A. M. , Gladstone G. R. , Greathouse T. K. , Bolton S. J. , Levin S. M. 
Published: August 2019

AbstractThe polar orbit of Juno at Jupiter provides a unique opportunity to observe high‐latitude energetic particle injections. We measure energy‐dispersed impulsive injections of protons and electrons. Ion injection signatures are just as prevalent as electron signatures, contrary to previous equatorial observations. Included are previously unreported observations of high‐energy banded structures believed to be remnants of much earlier injections, where the particles have had time to disperse around Jupiter. A model fit of the injections used to estimate timing fits the shape of the proton signatures better than it does the electron shapes, suggesting that electrons and protons are different in their abilities to escape the injection region. We present ultaviolet observations of Jupiter's aurora and discuss the relationship between auroral injection features and in situ injection events. We find, unexpectedly, that the presence of in situ particle injections does not necessarily result in auroral injection signatures.
Quantifying the Local Effect of Northern Hemisphere Atmospheric Blocks on the Persistence of Summer Hot and Dry Spells
Authors: Röthlisberger Matthias , Martius Olivia 
Published: August 2019

AbstractThe persistence of heat waves and droughts is a key factor in determining their societal impact. Here, the local effect of atmospheric blocks on the persistence of summer hot and dry spells is quantified by comparing their climatological daily survival probability, that is, the probability to survive the next day, to their daily survival probability when they co‐occur with a block. The survival odds of hot spells are increased by more than 50% over most of the Northern Hemisphere extratropical land masses when co‐occurring with blocks. Dry spell persistence is also strongly increased by colocated blocks over western North America, Europe, and southern Russia, while it is significantly decreased over the western North Atlantic and the western North Pacific. These spatial differences in the effect of blocks on both spell types are explained by considering the spatially varying surface temperature and precipitation anomalies induced by the blocks.
Tectonism and Its Relation to Magmatism Around Santorini Volcano From Upper Crustal P Wave Velocity
Authors: Heath B. A. , Hooft E. E. E. , Toomey D. R. , Papazachos C. B. , Nomikou P. , Paulatto M. , Morgan J. V. , Warner M. R. 
Published: August 2019

AbstractAt extensional volcanic arcs, faulting often acts to localize magmatism. Santorini is located on the extended continental crust of the Aegean microplate and is one of the most active volcanoes of the Hellenic arc, but the relationship between tectonism and magmatism remains poorly constrained. As part of the Plumbing Reservoirs Of The Earth Under Santorini experiment, seismic data were acquired across the Santorini caldera and the surrounding region using a dense amphibious array of >14,300 marine sound sources and 156 short‐period seismometers, covering an area 120 km by 45 km. Here a P wave velocity model of the shallow, upper‐crustal structure (<3‐km depth), obtained using travel time tomography, is used to delineate fault zones, sedimentary basins, and tectono‐magmatic lineaments. Our interpretation of tectonic boundaries and regional faults are consistent with prior geophysical studies, including the location of basin margins and E‐W oriented basement faults within the Christiana Basin west of Santorini. Reduced seismic velocities within the basement east of Santorini, near the Anydros and Anafi Basins, are coincident with a region of extensive NE‐SW faulting and active seismicity. The structural differences between the eastern and western sides of Santorini are in agreement with previously proposed models of regional tectonic evolution. Additionally, we find that regional magmatism has been localized in NE‐SW trending basin‐like structures that connect the Christiana, Santorini, and Kolumbo volcanic centers. At Santorini itself, we find that magmatism has been localized along NE‐SW trending lineaments that are subparallel to dikes, active faults, and regional volcanic chains. These results show strong interaction between magmatism and active deformation.
Influence of Natural Climate Variability on the Extreme Ocean Surface Wave Heights Over the Indian Ocean
Authors: Kumar Prashant , Kaur Sukhwinder , Weller Evan , Min Seung‐Ki 
Published: August 2019

AbstractExtreme ocean waves are part of the climate system but responsible for significant impacts on coastal and offshore environments, structures, and populations. In the Indian Ocean (IO), the wind and wave climate can be significantly influenced by natural climate variability, such as the El Niño–Southern Oscillation (ENSO), Indian Ocean Dipole (IOD), and Southern Annular Mode (SAM), yet our understanding on their regional influence is limited, particularly for seasonal extremes. Here, seasonal extreme significant wave heights (SWHs) and winds in the IO are examined over the period 1957–2010 utilizing ERA‐20C reanalysis data and the nonstationary generalized extreme value distribution to understand climatic extremes, by considering climate indices as covariates. ENSO influence on extreme SWHs include increases in the Bay of Bengal, southwest tropical IO (TIO), southern IO (SIO; a broad extension south of Australia), and South China and Philippine (SCP) Seas, and decreases in the Arabian Sea in boreal summer during El Niño. Extreme SWH responses to the IOD include increases in the eastern TIO, southwest TIO, and SIO in boreal autumn during its positive phase. Lastly, Southern Annular Mode not only significantly affects the SIO year round but has a weak influence in the northern and tropical IO. Composite analysis of ENSO and IOD events further highlight in phase combinations display less significant influence than out of phase combinations during summer, but not autumn. Mean and extreme wind responses are consistent with SWH responses to natural climate variability, and climate mode teleconnection patterns help explain the seasonal variations.
The Interannual Variability of Surface Winds in Antarctica and the Surrounding Oceans: A Climatological Analysis Using the ERA‐Interim Reanalysis Data
Authors: Yu Lejiang , Zhong Shiyuan 
Published: August 2019

AbstractSeason‐dependent interannual variability of surface winds across Antarctica and the Southern Ocean is investigated using European Centre for Medium‐Range Weather Forecasts Interim (ERA‐Interim) reanalysis for 1979–2017 and the empirical orthogonal function (EOF) technique. The first three EOF modes, which account for 18–23%, 11–15%, and 8–10% of the total variances for the four austral seasons, are related to several known modes of Southern Hemisphere large‐scale circulation including the southern annular mode, Pacific South American (PSA), and Zonal Wave 3 (ZW3) and to sea surface temperature anomalies in eastern (Niño 3) and central (Niño 4) tropical Pacific Ocean. Specifically, EOF1 and EOF2 are significantly correlated with southern annular mode in all seasons except for autumn EOF2. Neither EOF1 nor EOF2 are significantly correlated to Niño 3, but Niño 4 is significantly correlated to winter EOF1 and to EOF2 in all seasons but winter. EOF1 is significantly related to ZW3 for all seasons but summer; however, no significant connection is found between EOF2 and ZW3. Significant correlations exist between spring and winter EOF2 and PSA1 and between spring EOF1 and PSA2. EOF3 is significantly correlated with Niño 3, Niño 4, and PSA2 in all seasons but summer. The spatial patterns of all three modes can be largely explained by the anomalous mean sea level pressure fields that strengthen or weaken climatological winds in different regions of the Antarctica and the Southern Ocean, although variations in katabatic forcing also plays a role in the variations of surface winds especially in East Antarctica and during winter season where and when katabatic forcing dominates.