bluuebunny/crossref_metadata_2025_split huggingface dataset:
PCI-DB: A novel primary tissue immunopeptidome database to guide next-generation peptide-based immunotherapy development
Authors: Lemke Steffen , Dubbelaar Marissa L. , Zimmermann Patrick , Bauer Jens , Nelde Annika , Gravel Naomi Hoenisch , Scheid Jonas , Wacker Marcel , Jung Susanne , Dengler Anna , Maringer Yacine , Rammensee Hans-Georg , Gouttefangeas Cécile , Fillinger Sven , Bilich Tatjana , Heitmann Jonas S. , Nahnsen Sven , Walz Juliane S. 
Published: December 2024

Abstract

Various cancer immunotherapies rely on the T cell-mediated recognition of peptide antigens presented on human leukocyte antigens (HLA). However, the identification and selection of naturally presented peptide targets for the development of personalized as well as off-the-shelf immunotherapy approaches remains challenging. Here, we introduce the open-access Peptides for Cancer Immunotherapy Database (PCI-DB, https://pci-db.org/), a comprehensive resource of immunopeptidome data originating from various malignant and benign primary tissues that provides the research community with a convenient tool to facilitate the identification of peptide targets for immunotherapy development. The PCI-DB includes > 6.6 million HLA class I and > 3.4 million HLA class II peptides from over 40 tissue types and cancer entities analyzed uniformly using high-sensitive nf-core bioinformatics pipelines and applying a global peptide false discovery rate. First application of the database provided insights into the representation of cancer-testis antigens across malignant and benign tissues, enabling the identification and characterization of cross-tumor entity and entity-specific tumor-associated antigens as well as naturally presented neoepitopes from frequent cancer mutations. Further, we used the PCI-DB to design personalized peptide vaccines for two patients suffering from metastatic cancer. In a retrospective analysis, PCI-DB enabled the composition of both a multi-peptide vaccine comprising non-mutated, highly frequent tumor-associated antigens matching the immunopeptidome of the individual patient´s tumor and a neoepitope-based vaccine matching the mutational profile of a cancer patient. Both vaccine approaches induced potent and long-lasting T-cell responses, accompanied by long-term survival of these advanced cancer patients. In conclusion, the PCI-DB provides a highly versatile tool to broaden the understanding of cancer-related antigen presentation and, ultimately, supports the development of novel immunotherapies.
Tumor Microenvironment In Head And Neck Cancer: Insights From Spheroids
Authors: Rao Anshu , Das Uddalak , Ghodeswar Amey , Chaturvedi Rupesh 
Published: December 2024

Abstract

The study of head and neck cancer (HNC) has been significantly enhanced by the development of 3D spheroid models, which closely replicate the in vivo tumor microenvironment (TME) by preserving cellular heterogeneity, hypoxic regions, and tumor-specific cell interactions. Traditional 2D models lack the capacity to capture these critical characteristics, which are essential for understanding tumor biology and therapeutic responses. This review summarizes recent advancements in HNC spheroid research, with a focus on their applications in drug testing, TME simulation, and therapeutic development. We discuss the role of spheroids in modeling key aspects such as drug resistance, hypoxia, cancer stem cell behavior, and epithelial-mesenchymal transition (EMT). Despite challenges, including variability and scalability limitations, 3D models hold significant promise for advancing precision medicine in HNC. We also explore the use of these models in evaluating therapeutic strategies, including chemotherapy, molecular-targeted therapies, and immunotherapy. Furthermore, we conduct a bibliometric analysis to assess research trends and identify emerging topics within the field of HNSCC and 3D tumor modeling. The ability of 3D spheroid models to predict patient-specific responses to treatment is highlighted, underscoring their potential for advancing personalized medicine. By examining key cellular processes that drive tumor progression and therapy resistance, we evaluate how effectively these models replicate tumor biology and speculate on future advancements that could further enhance their relevance in cancer research and treatme
Adapting to Adversity through Resilience: The Role of Integrated Health Services Delivery in Sustaining Routine Health Services During COVID-19
Authors: Hasan Md Zabir , Ahmad Iman , Lee Rachael , Haider Shams Shabab , Gupta Shivam 
Published: December 2024

Abstract

Background
The COVID-19 pandemic challenged health systems in low- and lower-middle-income countries (L-LMICs), emphasizing the need for resilience—the ability to predict, prepare for, absorb, and adapt to external shocks while maintaining essential functions and improving performance. This scoping review examined the application of Integrated Health Service Delivery (IHSD) strategies to sustain routine (non-COVID-19) healthcare services during the pandemic.
Methods
We searched PubMed/MEDLINE, Scopus, EMBASE, Web of Science, CINAHL Plus, Cochrane, and the WHO Global Research on COVID-19 database from 01 January 2020 to 02 December 2022 for peer-reviewed studies written in English, based on a published protocol (doi: 10.1136/bmjopen-2020-042872).
Results
Of the 4,286 records screened, 30 studies were included in the review, encompassing a range of health topics, including systems strengthening (n = 8), noncommunicable diseases (n = 6), specialized care (n = 6), HIV (n = 3), mental health (n = 3), and other services (n = 3), highlighting the versatility of IHSD models during the pandemic. The results showed a dynamic blend of four typologies of IHSD – organizational (n = 15), functional (n = 17), service (n = 27), and clinical integration (n = 15) – each contributing significantly to the resilience of health systems. Organizational integration facilitated effective coordination and multisectoral collaboration; functional integration emphasized building workforce capacity and digital infrastructure; service integration adapted care delivery through community outreach and telehealth; and clinical integration supported the adoption of new care protocols.
Conclusion
This review offers critical insights into the application of integrated care approaches, demonstrating their potential to enhance system resilience and inform future health system strengthening efforts in L-LMICs amid ongoing and future healthcare challenges.
Effect of colored traps and sex pheromone on the capture of Spodoptera frugiperda
Authors: Brandão Janethe Machado , Magalhães Vinícius Silva , Barbosa Cejana Rayssa de Jesus , Solá Filipe Augusto , Rosa Maria Eduarda Monteiro , Godinho Karina Cordeiro Albernaz , Czepak Cecilia 
Published: December 2024

Abstract

Spodoptera frugiperda (Smith, 1797) (Lepidoptera: Noctuidae), stands out as one of the main pests threatening the productivity of the corn crop (Zea mays L.). The search for new control strategies has proved important given that the use of insecticides predominates. A sustainable alternative is the use of sex pheromone traps to monitor and manage pests. These traps help identify the most appropriate time to implement control measures, minimizing dependence on insecticides. Research into the color preferences of insects can improve the effectiveness of these traps. The experiment was conducted in four different regions of Goiás, namely: Silvânia, Pontalina, Vianópolis and Palminópolis, using a randomized block design with five treatments and four replications, for each target pest. The treatments consisted of Delta-type traps in five colors: white, yellow, red, blue and black, and synthetic S. frugiperda sex pheromones were placed in all the traps. Each week, the glue bases were quantified in terms of the number of specimens captured and replaced with a new base. In the case of the pheromones, they were changed every 21 days. The count data was analyzed using generalized linear models, using the Poisson distribution. The red color was more attractive to S. frugiperda, while the white color was more attractive to predatory insects.
Effectiveness of an Internet-Based Self-Help Acceptance and Commitment Therapy Program on Medical Students’ Mental Well-Being: Follow-Up Randomized Controlled Trial
Authors: Wang Difan , Lin Bingyan , Zhang Shuangxi , Xu Wei , Liu Xinying 
Published: December 2024

Background
Psychological distress is a growing problem among medical students worldwide. This highlights the need for psychological interventions to focus on mental health and improve well-being in this population.

Objective
This study developed an internet-based, self-help, acceptance and commitment therapy program (iACT 2.0), aiming to examine its effectiveness in reducing depression, anxiety, stress, psychological inflexibility (PI), and obsessive-compulsive symptoms (OCSs) among medical students.

Methods
A total of 520 Chinese postgraduate medical students were randomly assigned to either an iACT 2.0 intervention group (n=260; six online lessons, once every 5 days) or a control condition (n=260; without intervention). Participants completed questionnaires including the 21-item Depression Anxiety Stress Scale, the revised Obsessive-Compulsive Inventory, and the Multidimensional Psychological Flexibility Inventory at the preintervention (T1), postintervention (T2), and 1-month follow-up time points (T3). No therapist support was provided during the 1-month iACT 2.0 intervention period. Data were collected via an online platform and analyzed using repeated-measures ANOVA.

Results
Participants in the intervention group demonstrated a significant decrease in depression, anxiety, stress, PI, and OCSs compared to the control group after the intervention (F=22.9-672.04, all P<.001). Specifically, the intervention group showed significant reductions in all measured outcomes from the preintervention to postintervention time point and at the 1-month follow-up (all P<.001). In contrast, no significant changes were observed in the control group over the same period (all P>.05). The groups did not differ significantly at baseline (all P>.05). Significant differences were noted at both the postintervention and follow-up time points (all P<.001).

Conclusions
This study demonstrated that the newly developed iACT 2.0 was effective in reducing depression, anxiety, stress, PI, and OCSs. Notably, the positive effects of the intervention persisted at the 1-month follow-up. This program can offer a useful addition to existing mental illness treatment and lead to improvements in clinical and psychotherapy planning while simultaneously reducing the burden on traditional counseling and services.

Trial Registration
Chinese Clinical Trial Registry ChiCTR2300070725; https://tinyurl.com/2h75wx8n
Evaluating the Prognostic and Clinical Validity of the Fall Risk Score Derived From an AI-Based mHealth App for Fall Prevention: Retrospective Real-World Data Analysis
Authors: Alves Sónia A , Temme Steffen , Motamedi Seyedamirhosein , Kura Marie , Weber Sebastian , Zeichen Johannes , Pommer Wolfgang , Baumgart André 
Published: December 2024

Abstract

Background
Falls pose a significant public health concern, with increasing occurrence due to the aging population, and they are associated with high mortality rates and risks such as multimorbidity and frailty. Falls not only lead to physical injuries but also have detrimental psychological and social consequences, negatively impacting quality of life. Identifying individuals at high risk for falls is crucial, particularly for those aged ≥60 years and living in residential care settings; current professional guidelines favor personalized, multifactorial fall risk assessment approaches for effective fall prevention.

Objective
This study aimed to explore the prognostic validity of the Fall Risk Score (FRS), a multifactorial-based metric to assess fall risk (using longitudinal real-world data), and establish the clinical relevance of the FRS by identifying threshold values and the minimum clinically important differences.

Methods
This retrospective cohort study involved 617 older adults (857 observations: 615 of women, 242 of men; mean age 83.3, SD 8.7 years; mean gait speed 0.49, SD 0.19 m/s; 622 using walking aids) residing in German residential care facilities and used the LINDERA mobile health app for fall risk assessment. The study focused on the association between FRS at the initial assessment (T1) and the normalized number of falls at follow-up (T2). A quadratic regression model and Spearman correlation analysis were utilized to analyze the data, supported by descriptive statistics and subgroup analyses.

Results
The quadratic model exhibited the lowest root mean square error (0.015), and Spearman correlation analysis revealed that a higher FRS at T1 was linked to an increased number of falls at T2 (ρ=0.960, P<.001). Subgroups revealed significant strong correlations between FRS at T1 and falls at T2, particularly for older adults with slower gait speeds (ρ=0.954, P<.001) and those using walking aids (ρ=0.955, P<.001). Threshold values revealed that an FRS of 45%, 32%, and 24% corresponded to the expectation of a fall within 6, 12, and 24 months, respectively. Distribution-based minimum clinically important difference values were established, providing ranges for small, medium, and large effect sizes for FRS changes.

Conclusions
The FRS exhibits good prognostic validity for predicting future falls, particularly in specific subgroups. The findings support a stratified fall risk assessment approach and emphasize the significance of early and personalized intervention. This study contributes to the knowledge base on fall risk, despite limitations such as demographic focus and potential assessment interval variability.
Investigating the Norwegian eHealth Governance Model: Document Study
Authors: Linstad Line Helen , Bjørnå Hilde , Moen Anne , Tunby Kristiansen Truls , Hansen Anne Helen 
Published: December 2024

Background
Governments and policy makers struggle to achieve a balance between hierarchical steering and horizontal governance in systems characterized by fragmented decision authority and multiple interests. To realize its One Citizen–One Journal eHealth policy vision, the Norwegian government established a special eHealth board of stakeholders to create an inclusive governance model that aligned stakeholders’ interests with the government’s ambitions through coordination and consensus. Little empirical knowledge exists on how countries realize inclusive governance models.

Objective
This study aims to investigate how the Norwegian inclusive eHealth governance model was developed as a tool to align the government’s policy ambitions with stakeholders’ concerns from January 2012 to December 2022.

Methods
This document study used a thematic analysis based on a constructivist research approach. We included 16 policy documents and 175 consultation response documents issued between January 2012 and December 2022 related to the Norwegian One Citizen–One Journal policy implementation process. The themes were constructed deductively from a review of governance models and public governance theory and were applied as our analytical lens to each document. The findings were interpreted, analyzed, and synthesized.

Results
The national policy implementation process progressed through 3 phases, with changes in stakeholder inclusion and perceived influence on the decision-making process characterizing transitions from phase to phase. Tension developed between 2 contrasting views regarding top-down government authority and stakeholders’ autonomy. The view of the regional health trusts, municipalities, health care professional organizations, and industry actors contrasted with that of the patient organizations. Governmental insensitivity to participation, lack of transparency, and decreasing trust by stakeholder groups challenged the legitimacy of the inclusive governance model.

Conclusions
We illustrated that Norway’s One Citizen–One Journal policy trajectory was characterized by a process that unfolded across 3 distinct phases. The process was characterized by 2 contrasting stakeholder perspectives. Finally, it was shaped by diminishing trust in the inclusive governance model. The National eHealth Governance Board faced challenges in establishing legitimacy as a top-down inclusive governance model, primarily attributed to its addressing of participation, transparency, and trust dilemmas. Such dilemmas represent significant obstacles to inclusive governance models and require ongoing governmental vigilance and responsiveness from governmental entities.
Penguatan Keberlanjutan Ekowisata dan Ekonomi Lokal Melalui Budidaya Lebah Trigona
Authors: Sumandya I Wayan , Pranata I Kadek Yudha , Dharmadewi A.A.Istri Mirah , Wijaya Made Agus , Dewi Ni Putu Sri Ratna , Suryawan I Putu Pasek , Adnyani I Gusti Ketut , Ardanantya I Gusti Ayu Mira , Yuda I Putu Darma , Leonita A Tiurma Silvia , Herawati Desak Made Echa 
Published: December 2024

Program pengabdian masyarakat ini bertujuan untuk mendukung keberlanjutan ekologis dan ekonomi di Taman Wisata Samblong melalui budidaya lebah Trigona. Metode pelaksanaan mencakup sosialisasi, pelatihan, dan pendampingan, yang melibatkan Kelompok Sadar Wisata Harmoni Pertiwi Bali. Hasil menunjukkan peningkatan pengetahuan masyarakat tentang budidaya lebah, peningkatan produksi madu hingga 200 ml per sarang dalam panen pertama, serta diversifikasi produk seperti propolis dan bee pollen. Program ini juga berhasil meningkatkan daya tarik wisata melalui inisiatif ekowisata edukatif. Dengan pendekatan ini, keberlanjutan lingkungan dan kesejahteraan masyarakat lokal dapat terwujud, menjadikan Taman Wisata Samblong sebagai model ekowisata berbasis pemberdayaan masyarakat. Program ini memberikan kontribusi pada literatur pengabdian masyarakat dalam kaitannya dengan pengelolaan sumber daya lokal yang berkelanjutan.

This community service program aims to support ecological and economic sustainability in Samblong Tourism Park through Trigona bee cultivation. The implementation method includes socialization, training, and mentoring, involving the Harmoni Pertiwi Bali Tourism Awareness Group. The results show an increase in community knowledge about bee cultivation, an increase in honey production of up to 200 ml per hive in the first harvest, and product diversification such as propolis and bee pollen. This program has also succeeded in increasing tourist appeal through educational ecotourism initiatives. With this approach, environmental sustainability and the welfare of local communities can be realized, making Samblong Tourism Park a model of community empowerment-based ecotourism. This program contributes to the literature on community service in relation to sustainable local resource management.
MENINAS VESTEM ROSA, MENINOS VESTEM AZUL E O CONSERVADORISMO VESTE FARDA:
Authors: De Aragão Uchôa Fernandes Raquel , Cavalcante Vilar Lima Mirella 
Published: December 2024

Este estudo teve como objetivo analisar as configurações e impactos da agenda familista nos sucessivos ataques aos ordenamentos jurídico-legais e à educação pública. Parte de uma análise sobre a atuação do Ministério da Mulher, da Família e dos Direitos Humanos (MMFDH), sob o comando da Ministra Damares Alves, e da incidência desta gestão, e do projeto a que se filiou, no campo da educação. Em tal projeto há uma presença supervalorizada da família para a reprodução social, em detrimento do Estado, o que representa um retrocesso em várias pautas estruturantes, dando espaço para a defesa de propostas ultraconservadoras como as de combate à “ideologia de gênero” e de defesa do modelo único de família. Esta perspectiva está no centro das pautas da nova direita, materializada no Brasil mais recentemente pela eleição do Presidente Jair Messias Bolsonaro, que lançou mão, através do MMFDH, de uma série de políticas públicas chamadas de familiares com incidência em diferentes campos. Consideramos que uma gramática político-pedagógica alicerçada no fascismo, no pânico moral e no desmantelamento do Estado, teve severos rebatimentos na educação. Para atender aos objetivos propostos, realizou-se revisão da literatura sobre as principais categorias abordadas, e a análise documental de atos normativos e documentos institucionais do MMFDH. Ainda que estejamos vivenciando um momento de transformação no cenário político consideramos importante evidenciar para não repetirmos os atos absurdos da história recente.
Identifying the Relationship between Earnings and Prices
Authors: Starica Catalin , Marton Jan P. 
Published: December 2024

ABSTRACT
The relationships between accounting earnings and stock prices, as well as between unexpected earnings and returns, have received substantial attention in the empirical literature. Several theoretical models predict the shapes of these relationships. However, a comprehensive empirical description that could be used to evaluate these predictions is lacking. By integrating recent advances in statistics and machine learning with findings in the accounting literature, we develop an empirical method to identify the relationships, which is consistent with the firm-specific and nonlinear features of the theoretical models. Our approach provides a clear description of stylized and robust patterns in the relationships that are relevant to distinguish between existing models and to aid future theory development. The findings are consistent with recently proposed dynamic option models for both the earnings-price and unexpected earnings-returns relationships.
Data availability: Data are available from the public sources cited in the text. A summary of the R code used in the article is available in Starica and Marton (2024).
JEL Classifications: G10; G30; M41.
Hvem er herre over smaken? Unge kokkeelevers opplevelse av smak
Authors: Bødtker-Lund Daniel , Dæhlen Marianne , Fooladi Erik Cyrus 
Published: December 2024

Denne artikkelen beskriver hvordan unge kokkeelever forholder seg til smak gjennom opplæringen i vg1 restaurant- og matfag i den videregående skolen. Empirien er innhentet gjennom fire ukers observasjon av elever i to vg1-klasser, og fokusgruppeintervjuer av elevene som hadde søkt seg videre til vg2 kokk og servitør. Resultatene antyder en todeling i hvordan elevene erfarer smak. På den ene siden ser vi at elever snakker om smak som en personlig opplevelse knyttet til individuelle preferanser, noe som kan være et resultat av erfaringer og bakgrunn. På den andre siden posisjonerer elevene seg selv som profesjonelle, nemlig som kokker som skal lage og servere mat til andre (gjester/kunder), og der kokkens personlige smak må settes i bakgrunnen. Våre funn peker mot et behov for tydeligere tilnærminger til undervisning om smak i yrkesopplæringen, samt at læringsressurser og læreverk har et tydeligere utviklet didaktisk perspektiv på kompleksiteten i yrkesrettet smaksopplæring.
ENGLISH ABSTRACT
Who Is the Master of Taste? Young Chef Students’ Experience of Taste
The present article describes how young chef students relate to taste through their first year of culinary education in upper secondary vocational school in Norway. The research data were obtained during four weeks of observation of students in two first-year classes followed by focus group interviews. The results suggest a dichotomy in how students experience taste. On the one hand, we find that students talk about taste as a personal experience, linked to individual preferences, which might be a result of life experiences and personal background. On the other hand, students position themselves as nascent professionals, namely as chefs who will prepare and serve food to others (diners/customers), and where the chef’s personal taste must play second fiddle. Our findings point to a need for clearer approaches to teaching about taste in vocational training, as well as the need for a more elaborately developed didactic perspective on the complexity of vocational taste training in learning resources and textbooks.