bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sosyal Medya Platformu Seçimini Etkileyen Kriter Ağırlıklarının Bulanık DEMATEL Yöntemiyle Belirlenmesi
Authors: Oralhan Burcu 
Published: September 2019

Hızlı
etkileşim günümüzde sosyal medyanın sahip olduğu en önemli özelliklerinden
biridir. İşletmelerin reklam faaliyetlerinde sosyal medya, diğer pazarlama
kanallarına göre daha fazla kişiye ulaşabilme imkanı sağlamaktadır. Ancak dünya
genelinde sosyal medya platformlarının sayısı gün geçtikçe artmakta ve bu
platformlardaki tüketici eğilimi değişiklik göstermektedir. İşletmeler
tarafından yatırım yapılacak olan reklam faaliyetine yönelik sosyal medya
platformunun belirlenmesi bir çok kriterli karar verme problemidir. Sosyal
medya platformu seçim problemleri çok sayıda ve çoğu zaman birbiriyle çelişen
kriterler içeren karmaşık problemlerdir. Bu araştırmada Türkiye’de
telekomünikasyon sektöründe öncü bir işletmenin sosyal medya platformlarının
seçiminde önem arz eden kriterlerin ve etki düzeylerinin belirlenmesi ve
ağırlıklarının hesaplanması amaçlanmaktadır. Ağırlıkların hesaplanmasında
Bulanık DEMATEL yönteminden, durulaştırma aşamasında ise CFCS yönteminden
faydalanılmıştır. Araştırma kapsamında görünüm ve algı, içerik, maliyet, üye
profili, izlenim oranı ve teknik destek olmak üzere 6 kriter belirlenmiştir.
Analiz sonuçlarına göre izlenme oranı (0,185),
görünüm ve algı (0,181) ve üye profili (0,170) kriterleri sosyal medya
platformu seçiminde en fazla ağırlığa sahip ilk üç kriter olarak karşımıza
çıkmıştır. E+F değeri kriterlerin göreli önemini ifade
etmektedir. E-F değerleri
pozitif olan izlenme oranı, görünüm ve algı ve üye profili kriterleri diğer
kriterleri etkileyen grupta yer almaktadır. Dolayısıyla bu kriterlerin, diğer
kriterler üzerinde en çok etkiye sahip olduklarını söylenebilir. E-F değerleri
negatif olan maliyet, içerik ve teknik destek kriterleri ise etkilenen grupta
yer almaktadır. Etkilenen kriterler incelendiğinde ise E-F değeri en küçük olan maliyet kriterinin sosyal
medya platform seçiminde diğer kriterlerden en çok etkilenen kriter olduğu
görülmektedir. Bu çalışma genel olarak dijital pazarlama kanallarının seçimine,
kriter ağırlıklarının ve kriterlerin etki düzeylerinin belirlenmesine yönelik
yapılacak araştırmalara farklı bir bakış açısı kazandıracaktır.
Same Target, Different Therapeutic Outcomes: The Case of CAY10471 and Fevipiprant on CRTh2 Receptor in Treatment of Allergic Rhinitis and Asthma
Authors: Issahaku Abdul R. , Agoni Clement , Soremekun Opeyemi S. , Kubi Patrick A. , Kumi Ransford O. , Olotu Fisayo A. , Soliman Mahmoud E.S. 
Published: September 2019

Objective:Prostaglandin 2 (PGD2) mediated signalling of Chemoattractant Receptorhomologous molecule expressed on Th2 cells (CRTh2) receptor has been implicated in the recruitment of inflammatory cells. This explains the design of highly selective compounds with innate abilities to antagonize PGD2-CRTh2 interactions and prevent pro-inflammatory allergies such as rhinitis and uncontrolled asthma. The development of PGD2-competitive CRTh2 binders; CAY10471 and Fevipiprant represent remarkable therapeutic progress even though they elicit disparate pharmacological propensities despite utilizing the same binding pocket.Methods & Results:In this study, we seek to pinpoint the underlying phenomenon associated with differential CRTh2 therapeutic inhibition by CAY10471 and Fevipiprant using membraneembedded molecular dynamics simulation. Findings revealed that the common carboxylate group of both compounds elicited strong attractive charges with active site Arg170 and Lys210. Interestingly, a distinctive feature was the steady occurrence of high-affinity salt-bridges and an Arg170-mediated pi-cation interaction with the tetrahydrocarbozole ring of CAY10471. Further investigations into the active site motions of both ligands revealed that CAY10471 was relatively more stable. Comparative binding analyses also revealed that CAY10471 exhibited higher ΔG, indicating the cruciality of the ring stabilization role mediated by Arg170. Moreover, conformational analyses revealed that the inhibitory activity of CAY10471 was more prominent on CRTh2 compared to Fevipiprant.Conclusion:These findings could further advance the strategic design of novel CRTh2 binders in the treatment of diseases related to pro-inflammatory allergies.
Synthesis, Cytotoxicity and Molecular Docking Simulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages
Authors: Abdella Amna M. , Abdelmoniem Amr M. , Ibrahim Nada S. , El-Hallouty Salwa M. , Abdelhamid Ismail A. , Elwahy Ahmed H.M. 
Published: September 2019

Objective:Novel bis(1,4-dihydropyridine-3,5-dicarbonitrile) derivatives linked to aliphatic or aromatic cores via amide or ester-amide linkages were prepared and their structures were confirmed by several spectral tools.Methods:The synthesis of novel N,N'-(alkanediyl)bis(2-(2-(3,5-dicyano-2,6-dimethyl-1,4-dihydropyridin- 4-yl)phenoxy)acetamide) by acid-catalyzed condensation of the bis-aldehydes with four equivalents of 3-aminocrotononitrile was reported.Results:The structures of the synthesized compounds were confirmed by different spectral tools. The molecular docking stimulation studies indicated that the prepared compounds bind to the active site of cellular inhibitor apoptotic protein (cIAP1-BIR3). MTT assay for the novel bis(1,4-dihydropyridines) was performed on two different human cell lines (A549 and HCT116).Conclusion:Compound 5a showed higher cytotoxic activity against A549. Compound 5d showed moderate activity against HCT116. The rest of compounds indicated lower or no activity against both cell lines.
Quantitative Structure-Activity Relationship Study for HIV-1 LEDGF/p75 Inhibitors
Authors: Li Yang , Tian Yujia , Xi Yao , Qin Zijian , Yan Aixia 
Published: September 2019

Background:
HIV-1 Integrase (IN) is an important target for the development of the
new anti-AIDS drugs. HIV-1 LEDGF/p75 inhibitors, which block the integrase and LEDGF/p75
interaction, have been validated for reduction in HIV-1 viral replicative capacity.

Methods:
In this work, computational Quantitative Structure-Activity Relationship (QSAR) models
were developed for predicting the bioactivity of HIV-1 integrase LEDGF/p75 inhibitors. We collected
190 inhibitors and their bioactivities in this study and divided the inhibitors into nine scaffolds
by the method of T-distributed Stochastic Neighbor Embedding (TSNE). These 190 inhibitors
were split into a training set and a test set according to the result of a Kohonen’s self-organizing
map (SOM) or randomly. Multiple Linear Regression (MLR) models, support vector machine
(SVM) models and two consensus models were built based on the training sets by 20 selected
CORINA Symphony descriptors.

Results:
All the models showed a good prediction of pIC50. The correlation coefficients of all the
models were more than 0.7 on the test set. For the training set of consensus Model C1, which performed
better than other models, the correlation coefficient(r) achieved 0.909 on the training set,
and 0.804 on the test set.

Conclusion:
The selected molecular descriptors show that hydrogen bond acceptor, atom charges
and electronegativities (especially π atom) were important in predicting the activity of HIV-1 integrase
LEDGF/p75-IN inhibitors.
Association between hTERT Polymorphisms and Female Papillary Thyroid Carcinoma
Authors: Liu Ying , Li Zhi , Tang Xinyue , Li Min , Shi Feng 
Published: September 2019

Background:
A previous genome-wide association study showed that hTERT rs10069690
and rs2736100 polymorphisms were associated with thyroid cancer risk.

Objective:
This study further investigated the association between increased risk and clinicopathologic
characteristics for Papillary Thyroid Carcinoma (PTC) and hTERT polymorphisms rs10069690 or
rs2736100 in a Chinese female population.

Methods:
The hTERT genotypes of 276 PTC patients and 345 healthy subjects were determined with
regard to SNPs rs10069690 and rs2736100. The association between these SNPs and the risk of PTC
and clinicopathologic characteristics was investigated by logistic regression.

Results:
We found a significant difference between PTC and rs10069690 (Odds Ratio (OR) = 1.515; P
= 0.005), but not between PTC and rs2736100. When the analysis was limited to females, rs10069690
and rs2736100 were both associated with increased risk for PTC in female individuals (OR = 1.647, P
= 0.007; OR = 1.339, P = 0.041, respectively). Further haplotype analysis revealed a stimulative effect
of haplotypes TC and CA of TERT rs10069690-rs2736100, which increased risk for PTC in female
individuals (OR = 1.579, P = 0.014; OR = 0.726, P = 0.025, respectively). Furthermore, the heterozygote
A/C of rs2736100 showed significant difference for age (OR = 0.514, P = 0.047).

Conclusion:
Our finding suggests that hTERT polymorphisms rs10069690 and rs2736100 are associated
with increased risk for PTC in Chinese female population and rs2736100 may be related to age.
Consistent with US20170360914 and US20170232075, they are expected to be a potential molecular
target for anti-cancer therapy.
Transcriptional Regulation Analysis of Alzheimer's Disease Based on FastNCA Algorithm
Authors: Sun Qianni , Kong Wei , Mou Xiaoyang , Wang Shuaiqun 
Published: September 2019

Background:
Understanding the relationship between genetic variation and gene expression
is a central issue in genetics. Although many studies have identified genetic variations associated
with gene expression, it is unclear how they perturb the underlying regulatory network of
gene expression.

Objective:
To explore how genetic variations perturb potential transcriptional regulation networks
of Alzheimer’s disease (AD) to paint a more complete picture of the complex landscape of transcription
regulation.

Methods:
Fast network component analysis (FastNCA), which can capture the genetic variations
in the form of single nucleotide polymorphisms (SNPs), is applied to analyse the expression activities
of TFs and their regulatory strengths on TGs using microarray and RNA-seq data of AD.
Then, multi-data fusion analysis was used to analyze the different TGs regulated by the same TFs
in the different data by constructing the transcriptional regulatory networks of differentially expressed
genes.

Results:
the common TF regulating TGs are not necessarily identical in different data, they may be
involved in the same pathways that are closely related to the pathogenesis of AD, such as immune
response, signal transduction and cytokine-cytokine receptor interaction pathways. Even if they are
involved in different pathways, these pathways are also confirmed to have a potential link with
AD.

Conclusion:
The study shows that the pathways of different TGs regulated by the same TFs in different
data are all closely related to AD. Multi-data fusion analysis can form a certain complement
to some extent and get more comprehensive results in the process of exploring the pathogenesis
of AD.
Skin Allergy to Azole Antifungal Agents for Systemic Use: A Review of the Literature
Authors: Calogiuri Gianfranco , Garvey Lene H. , Nettis Eustachio , Romita Paolo , Di Leo Elisabetta , Caruso Riccardo , Butani Lavjay , Foti Caterina 
Published: September 2019

Background:
Antifungal azoles are the first-line agents used to treat topical and, above all,
systemic mycosis. The latter could be life-threating infections in immunocompromised patients. Chemotherapeutic
antibiotics, including antifungal azoles, may induce hypersensitivity reactions; however,
such immunologic adverse reactions have not been defined and carefully investigated.

Objective:
The study aims to provide an update on the evaluation and diagnosis of skin allergy to azole
antifungal agents.

Methods:
This is a systematic review performed on PubMed and Google Schoolbarusing using the key
terms “allergy, hypersensitivity, anaphylaxis, immediate-type reaction, delayed-type reaction, ketoconazole,
fluconazole, posaconazole, voriconazole, itraconazole, triazoles, imidazoles, antifungals,
antimycotics”. The search strategy included meta-analyses, randomized controlled trials, clinical trials,
observational studies, reviews and case reports.

Results:
One hundred twenty-four articles matched our search terms. The most common adverse events
reported were T-cell mediated delayed-type hypersensitivity reactions, fixed drug eruptions, exanthematous
dermatitis, Steven-Johnson syndrome, toxic epidermal necrolysis and acute generalized exhanthematous
pustulosis. Rarely a drug rash with eosinophilia systemic symptoms, has been described.
Also, immediate-type reactions such as urticaria-angioedema or anaphylaxis have been reported following
the administration of antifungal imidazoles, although not so frequently.

Conclusion:
Despite their widespread use, triazoles seem to induce rare cutaneous hypersensitivity
reactions, but the pathomechanisms, risk factors, diagnostic and management strategies, including skin
tests and challenge tests, are little known and poorly investigated.
Enhancement of Dissolution Rate of Quercetin Using Solid Dispersion Approach: In Vitro and In Vivo Evaluation
Authors: Chaubey Raghvendra , Srivastava Nimisha , Singh Apoorva 
Published: September 2019

Objective:
The objective of present study was to enhance the potential activities of
Quercetin by improving its solubility and dissolution profiles through solid dispersion approach.

Method:
A three level full factorial design (32) was adopted to study the possible combinations of
polyethylene glycol (PEG) 6000 & pluronic F 127 (PF 127). The solid dispersions were prepared
by solvent evaporation method and evaluated for percentage yield, drug content, aqueous solubility
and drug release. For in vivo evaluations SD4 was incorporated into Carbopol base gel and
subjected to anti-inflammatory activity using carrageenan-induced rat paw edema method.

Results:
SD4 batch with drug to carrier ratio 1:1 showed release of 82.96 ± 1.76 % in 240 min following
Higuchi’s model. It was 5.54 fold increment in solubility as compared to quercetin. SD4
batch was further evaluated by FTIR, DSC, PXRD and SEM. The crystallinity was significantly
reduced and drug was homogeneously dispersed in the carrier as shown by the results of DSC,
PXRD and SEM. The DPPH scavenging assay showed significance in the IC50 value of SD4 as
compared to pure quercetin and ascorbic acid when subjected to one way ANOVA at 0.05 level of
significance (P<0.0001). In vivo anti-inflammatory study showed 78.17 ± 0.156 % inhibition of
edema by SD4 and 58.64 ± 0.640 % by pure quercetin which is significantly lower (P<0.05).

Conclusion:
These findings demonstrate that the solid dispersion of quercetin shows increased
solubility, dissolution profile, drug release and significant potential in enhancing the antiinflammatory
activity of drug.
Formulation Optimization and Biopharmaceutical Evaluation of Imatinib Mesylate Loaded β-cyclodextrin Nanosponges
Authors: Kamble Milind , Zaheer Zahid , Mokale Santosh , Zainuddin Rana 
Published: September 2019

Background:
Many researchers have prepared and evaluated nanosponges and
claimed their advantages as an effective drug carrier, especially it was observed prominently
in case of anti-fungal drugs. The materials employed to synthesize nanosponges were
mainly crosslinking agents, different beta-cyclodextrin and other cellulose-based polymers.
Many of them had used ratio proportions of cross-linking agents, d polymers to synthesize
these nanosponges which ultimately produce a porous mesh-like network known as nanosponges
where actually drug is encapsulated or loaded.

Objective:
In the present investigation, we observed the effect of various levels of crosslinking
agents and beta-cyclodextrin concentrations on porosity, drug encapsulation, zeta
potential and drug release by employing the quality by design approach to synthesize nanosponges
rather than merely keeping both concentrations in proportions.

Methods:
We have slightly modified the method reported earlier i.e. melting method in
which we have used rota evaporator receiver vessel for melting cross-linking agent and beta-
cyclodextrin, rotated at 20 RPM at 100°C.

Results:
In a quality by design approach, we observed that out of four dependent variables
i.e. porosity, drug loading, zeta potential and drug release, three significantly depend on the
crosslinking of beta-cyclodextrin molecules which is highly appreciated by the amount of
cross-linking agent present in the reaction. The pharmacokinetics of Imatinib loaded optimized
nanosponges were compared with the reference product to observe the pattern of absorption
and disposition.

Conclusion:
Nanosponges synthesized by optimization technique could be effective means
of anti-cancer drug oral administration as they encapsulate the drug effectively and offer a
prolonged release of drug which gradually releases the drug and avoids unnecessary exposure
of the drug.
The Influence of CeO2-Doping of Nanosized Cadmium Ferrite on Catalytic Conversion of Ethanol
Authors: Badawy Abdelrahman A. , Rashad Ahmed M. , Ibrahim Shaimaa M. , El-Khouly Sahar M. 
Published: September 2019

Background:
The role of CeO2-doping (0.75-3 mol%) and calcination temperature on solid-solid interaction between ferric and cadmium oxides yielding cadmium ferrites was examined.

Methods and Results:
The results exposed that ceria improves the ferrite formation by heating at 600-700ºC via the dissolution of some dopant cation in the lattice of CdO with the subsequent creation of anionic vacancies and/or formation of higher valency cadmium cation (Cd(2+δ)+). SBET of solids calcined at 500oC increased by CeO2-doping, while opposite trend for solids calcined at 600 and 700oC. The magnetic hysteresis loops of all samples showed room-temperature ferromagnetism with different hysteresis loop shapes.

Conclusion:
Magnetization increased by CeO2-doping that might be due to the enhancement of cadmium ferrite formation. Ethanol conversion increased by increasing CeO2-doping. Dehydrogenation product (acetaldehyde) was mainly the yield of ethanol conversion. The maximum yield of acetaldehyde (92.97%) carried out for solids doped with 3 mol% CeO2.
IN VITRO INHIBITORY ACTIVITY OF BERBERIS VULGARIS L. AGAINST LEISHMANIA TROPICA PROMASTIGOTES
Authors: Ozbilgin Ahmet , Kayalar Husniye , Cavus Ibrahim , Durmuskahya Cenk , Toktas Umit , Gunduz Cumhur 
Published: September 2019

In the present study it was aimed to determine the in vitro antileishmanial activity of Berberis vulgaris L. against Leishmania tropica promastigotes. The aerial parts of Berberis vulgaris were collected from Spil Mountain, Manisa. The ethanolic extract of the plant material was prepared. The consecutive concentrations of the plant extract (25-100µg/ml) were set for in vitro antileishmanial assays. In addition to in vitro inhibitory activities against Leishmania tropica promastigotes, the cytotoxicity of the plant extract was also measured by WST-1 Cell proliferation assay. The percentages of parasite inhibition in the presence of B. vulgaris ethanol extract in comparison with glucantime reference group at time interval of 12-72 hours were observed between 88.0 and 100.0 %. The plant extract was found to have cytotoxic activity with 444, 81±2, 12 µg/ml IC50 value.This is the first study that involves the in vitro antileishmanial activity of B. vulgaris which is wildly growing in Manisa, Turkey. Initial results demonstrated that the ethanolic extract of B. vulgaris gave promising results and it could be used as an antileishmanial agent in future.
COCCIDIAN INTESTINAL PARASITES AMONG CHILDREN IN AL-TORBAH CITY IN YEMEN: IN COUNTRY WITH HIGH INCIDENCE OF MALNUTRITION
Authors: Shamsan Emad Najeeb Ali , De-ping CAO , Al-Shamahy Hassan A. , Ali Al- Hajj Manal Mutaher , Bo-fan JIANG , Yaogang Zhang 
Published: September 2019

Diarrhoea is an important cause of malnutrition, morbidity and mortality among children in Yemen. Coccidian parasitic infections are an important cause of diarrhea in children particularly malnutrition and immune-compromised patients, but their investigations are rarely required by the treating physicians in apparently immunocompetent children. This study was aimed to find the prevalence of intestinal coccidian parasites in country with high incidence rate of malnutrition. Between May 2016 and October 2016, 228 fecal samples from 228 selected school children in Al Turbah city, Taiz governorate, Yemen, aged between 6 and 15 years were examined using wet-mount preparations and formal concentration method then films stained by modified acid-fast staining. Also data of children were collected including demographic data, and sources of water. Findings of positive intestinal coccidian parasites were analyzed in relation with demographic data, and sources of water. The prevalence of Cryptosporidium species, Cyclospora species and Isospora belli were 75.9%, 45.6% and 1.75% respectively. There was significant association between positive of Cryptosporidium species and females (OR= 2.1 times, P=0.01), and spring water source (OR=4 times, P=0.04), while there was no significant association between positive of Cryptosporidium species and others factors studied. Also there was no significant association between positive of Cyclospora species and Isospora belli and children sex, age groups, or different sources of water. In conclusion the study highlights the high prevalence of coccidian parasites among immunocompetent school children in Yemen. The clinicians in Yemen need to be aware that coccidian parasites are a potential cause of childhood diarrhea even in immunocompetent children.
Racial/Ethnic Disparities in the Prevalence of Diabetes and Prediabetes by BMI: Patient Outcomes Research To Advance Learning (PORTAL) Multisite Cohort of Adults in the U.S.
Authors: Zhu Yeyi , Sidell Margo A. , Arterburn David , Daley Matthew F. , Desai Jay , Fitzpatrick Stephanie L. , Horberg Michael A. , Koebnick Corinna , McCormick Emily , Oshiro Caryn , Young Deborah R. , Ferrara Assiamira 
Published: September 2019

OBJECTIVETo examine racial/ethnic disparities in the prevalence of diabetes and prediabetes by BMI category.RESEARCH DESIGN AND METHODSIn a consortium of three U.S. integrated health care systems, 4,906,238 individuals aged ≥20 years during 2012–2013 were included. Diabetes and prediabetes were ascertained by diagnosis and laboratory results; antihyperglycemic medications were also included for diabetes ascertainment.RESULTSThe age-standardized diabetes and prediabetes prevalence estimates were 15.9% and 33.4%, respectively. Diabetes but not prediabetes prevalence increased across BMI categories among all racial/ethnic groups (P for trend &lt; 0.001). Racial/ethnic minorities reached a given diabetes prevalence at lower BMIs than whites; Hawaiians/Pacific Islanders and Asians had a diabetes prevalence of 24.6% (95% CI 24.1–25.2%) in overweight and 26.5% (26.3–26.8%) in obese class 1, whereas whites had a prevalence of 23.7% (23.5–23.8%) in obese class 2. The age-standardized prediabetes prevalence estimates in overweight among Hispanics (35.6% [35.4–35.7%]), Asians (38.1% [38.0–38.3%]), and Hawaiians/Pacific Islanders (37.5% [36.9–38.2%]) were similar to those in obese class 4 among whites (35.3% [34.5–36.0%]), blacks (36.8% [35.5–38.2%]), and American Indians/Alaskan Natives (34.2% [29.6–38.8%]). In adjusted models, the strength of association between BMI and diabetes was highest among whites (relative risk comparing obese class 4 with normal weight 7.64 [95% CI 7.50–7.79]) and lowest among blacks (3.16 [3.05–3.27]). The association between BMI and prediabetes was less pronounced.CONCLUSIONSRacial/ethnic minorities had a higher burden of diabetes and prediabetes at lower BMIs than whites, suggesting the role of factors other than obesity in racial/ethnic disparities in diabetes and prediabetes risk and highlighting the need for tailored screening and prevention strategies.