bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diverse progenitor cells preserve salivary gland ductal architecture after radiation induced damage
Authors: May Alison J. , Cruz-Pacheco Noel , Emmerson Elaine , Seidel Kerstin , Nathan Sara , Muench Marcus O. , Klein Ophir , Knox Sarah M. 
Published: April 2018

AbstractThe ductal system of the salivary gland has long been postulated to be resistant to radiation-induced damage, a common outcome incurred by head and neck cancer patients receiving radiotherapy. Yet, whether the ducts are capable of regenerating after genotoxic injury, or if damage to ductal cells induces lineage plasticity, as has been reported in other organ systems, remains unknown. Here, we show that two ductal progenitor populations marked by KRT14 and KIT exclusively maintain non-overlapping ductal compartments after radiation exposure but do so through distinct cellular mechanisms. KRT14+ progenitor cells are fast cycling cells that proliferate in response to radiation-induced damage in a sustained manner and divide asymmetrically to produce differentiated cells of the larger granulated ducts. Conversely, KIT+ cells are long lived progenitors for the intercalated ducts that undergo few cell divisions either during homeostasis or after gamma radiation, thus maintaining ductal architecture in the near absence of cell turnover. Together, these data illustrate the regenerative capacity of the salivary ducts and highlight the heterogeneity in the damage responses used by salivary progenitor cells to maintain tissue architecture.Summary StatementThe salivary gland ductal network is maintained during homeostasis and after genotoxic injury by diverse progenitors that respond differentially to radiation induced damage.
Active presynaptic ribosomes in mammalian brain nerve terminals, and increased transmitter release after protein synthesis inhibition
Authors: Scarnati Matthew S. , Kataria Rahul , Biswas Mohana , Paradiso Kenneth G. 
Published: April 2018

AbstractPresynaptic neuronal activity requires the localization of thousands of proteins that are typically synthesized in the soma and transported to nerve terminals. Local translation for some dendritic proteins occurs, but local translation in mammalian presynaptic nerve terminals is difficult to demonstrate. Here, we present evidence for local presynaptic protein synthesis in the mammalian brain at a glutamatergic nerve terminal. We show an essential ribosomal component, 5.8s rRNA, in terminals. We also show active translation in nerve terminals, in situ, in brain slices demonstrating ongoing presynaptic protein synthesis. After inhibiting translation for ~1 hour, the presynaptic terminal exhibits increased spontaneous release, and increased evoked release with an increase in vesicle recycling during stimulation trains. Postsynaptic response, shape and amplitude were not affected. We conclude that ongoing protein synthesis limits vesicle release at the nerve terminal which reduces the need for presynaptic vesicle replenishment, thus conserving energy required for maintaining synaptic transmission.
Development of the MAM model of schizophrenia in mice: Sex similarities and differences of hippocampal and prefrontal cortical function
Authors: Chalkiadaki Kleanthi , Velli Aggeliki , Kyriazidis Evangelos , Stavroulaki Vasiliky , Vouvoutsis Vasilis , Chatzaki Ekaterini , Aivaliotis Michalis , Sidiropoulou Kyriaki 
Published: April 2018

AbstractSchizophrenia is a debilitating disorder with complex and unclarified etiological factors. Sex differences have been observed in humans but animal models have only focused on male subjects. In this study, we report the establishment of the neurodevelopmental MAM model of schizophrenia in mice and compare the schizotypic-like characteristics and cognitive function in both sexes. Pregnant mice were injected with 26mg/kg(i.p.) of Methylazoxy-methanol acetate (MAM) or saline (5ml/kg) on gestational day (GD) 16 (MAM-16) or 17 (MAM-17). Behavioral, histological and electrophysiological and mass spectrometry-based comparative proteomic techniques were employed to assess the schizotypic-like characteristics and cognitive function of adult male and female offspring (MAM- or saline-treated). Female MAM-16, but not MAM-17 treated mice exhibited enhanced hyperlocomotion after acute administration of the NMDA receptor antagonist, MK-801, compared to saline treated mice. Male MAM-16, but not MAM-17 treated mice showed decreased pre-pulse inhibition of the acoustic startle reflex. Both male and female MAM-16 and MAM-17 treated mice exhibited reduced hippocampal (HPC) size and thinning of the prefrontal cortex (PFC), but only male MAM-16 treated mice showed decreased parvalbumin expression in HPC and PFC. Similarly, both male and female MAM-16 treated mice displayed impaired contextual fear memory, while only male MAM-16 treated mice exhibited deficits in the delayed alternation task. The neurophysiological mechanisms that underlie these cognitive functions were further investigated. Both male and female MAM-16 treated mice had significantly reduced long-term potentiation (LTP) in the HPC CA1 synapses, while only male MAM-16 treated mice exhibited decreased LTP in the PFC. Proteomic analyses of PFC lysates further showed significant MAM- and sex-dependent differences in regulation of protein expression. Our results demonstrate that while both male and female mice, prenatally exposed to MAM on GD16, display several core schizophrenia-like deficits and impairments in the hippocampus, only male MAM-treated mice have PFC-dependent cognitive deficits.
MEST induces epithelial-mesenchymal transition through IL-6/JAK/STAT3 signaling in breast cancers
Authors: Kim Min Soo , Lee Hyun Sook , Kim Yun Jae , Kang Sung Gyun , Lee Do Yup , Jin Wook 
Published: April 2018

AbstractThe loss of imprinting of MEST has been linked to certain types of cancer by promoter switching. However, MEST-mediated regulation of tumorigenicity and metastasis are yet to be understood. Herein, we reported that MEST is a key regulator of IL-6/JAK/STAT3/Twist-1 signal pathway-mediated tumor metastasis. Enhanced MEST expression is significantly associated with pathogenesis of breast cancer patients. Also, MEST induces metastatic potential of breast cancer through induction of the EMT-TFs-mediated EMT program. Moreover, MEST leads to Twist-1 induction by STAT3 activation and subsequently enables the induction of activation of the EMT program via the induction of STAT3 nuclear translocation. Furthermore, the c-terminal region of MEST was essential for STAT3 activation via the induction of JAK2/STAT3 complex formation. Finally, MEST significantly increases the breast cancer’s ability to metastasize from the mammary gland to the lung. These observations suggest that MEST is a promising target for intervention to prevent tumor metastasis.
Equitable Thresholding and Clustering (ETAC): A novel method for FMRI clustering in AFNI
Authors: Cox Robert W. 
Published: April 2018

ABSTRACTThis paper describes a hybrid method to threshold FMRI group statistical maps derived from voxelwise second-level statistical analyses. The proposed “Equitable Thresholding and Clustering” (ETAC) approach seeks to reduce the dependence of clustering results on arbitrary parameter values by using multiple sub-tests, each equivalent to a standard FMRI clustering analysis, to make decisions about which groups of voxels are potentially significant. The union of these sub-test results decides which voxels are accepted. The approach adjusts the cluster-thresholding parameter of each sub-test in an equitable way, so that the individual false positive rates (FPRs) are balanced across sub-tests to achieve a desired final FPR (e.g., 5%). ETAC utilizes resampling methods to estimate the FPR, and thus does not rely on parametric assumptions about the spatial correlation of FMRI noise. The approach was validated with pseudo-task timings in resting state brain data. Additionally, a task FMRI data collection was used to compare ETAC’s true positive detection power vs. a standard cluster detection method, demonstrating that ETAC is able to detect true results and control false positives while reducing reliance on arbitrary analysis parameters.
CCL3 promotes germinal center B cells sampling by follicular regulatory T cells
Authors: Benet Zachary L. , Marthi Matangi , Wu Rita , Turner Jackson S. , Gabayre Jahan B. , Ivanitskiy Michael I. , Sethi Sahil S. , Grigorova Irina L. 
Published: April 2018

ABSTRACTPrevious studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity is poorly understood. We found that CCL3 promotes chemotaxis of Tfr cellsex vivo. In vivoCCL3 is not required for Tfr cells recruitment of into the GC light zone. However, B cells-intrinsic production of CCL3 promotes their direct interactions and negative regulation by follicular regulatory T cells (Tfr) within GCs.
Teacher support for career development: an integrative review and research agenda
Authors: Zhang Jiahong , Yuen Mantak , Chen Gaowei 
Published: April 2018

Purpose
The purpose of this paper is to review identified key features of teacher support and its influence on students’ career decision making and development. It also examines the types of research approaches to data collection and analysis in order to provide a more in-depth evaluation of this field of study.

Design/methodology/approach
The review examined 18 studies, the majority being quantitative in design. Cross-sectional and longitudinal effects of teacher support were investigated, and differences in teacher support relative to grade level and gender were considered.

Findings
Results indicated that since 2000, there has been an increase in the number of empirical studies of teacher support in the career development field, the majority involving middle and high school students. The most commonly cited frameworks that underpin the studies are the social cognitive career theory, the career construction theory and Super’s career development theory. The most frequently used instrument for data collection was the teacher support scale (Metheny et al., 2008).

Originality/value
The review will be beneficial to researchers, teachers and policy makers seeking to optimize support systems for students’ career development. The findings contribute to further theory development and have practical implications for the career guidance field. Recommendations for future research and practice are suggested.
Ownership structure, board gender diversity and charitable donation
Authors: Lin Ting-Ling , Liu Heng-Yih , Huang Chi-Jui , Chen Yu-Chiung 
Published: April 2018

Purpose
This paper aims to examine the effect of ownership structure and board gender diversity on charitable donations for a group of listed electronics companies in Taiwan.

Design/methodology/approach
Using linear regression analysis, this paper analyses the ownership structure, board gender diversity and charitable donations of 380 Taiwanese electronics companies (2011-2013).

Findings
While domestic institutional investors, such as domestic mutual funds and corporate investors, take more of agency logic view, it negatively impacts on charitable donations. However, the empirical findings of this paper indicate that board gender diversity with the critical number of female directors was positively related to charitable donation. Thus, it is clear that female directors reaching critical numbers were taking more of a stakeholder view of institutional logic, emphasizing the balance of interests of internal and external stakeholders.

Research limitations/implications
This paper is limited to selected Taiwanese electronics companies over a two-year time frame, and charitable donations are the only proxy of corporate social responsibility (CSR) activity. The paper suggests that, as predicted by stakeholder theory and critical mass theory, companies with boards composed of at least three female directors make higher charitable donations.

Practical implications
This paper indicates that female directors on the board should have more voices on the board regarding the necessity and importance of CSR.

Originality/value
The paper contributes to existing literature by looking into the effects of ownership structure and board gender diversity on charitable donations.
Predicting the impacts of climate change on groundwater recharge in an arid environment using modeling approach
Authors: Ghazavi Reza , Ebrahimi Haidar 
Published: April 2018

Purpose
Groundwater is an important source of water supply in arid and semi-arid areas. The purpose of this study is to predict the impact of climate change on groundwater recharge in an arid environment in Ilam Province, west of Iran.

Design/methodology/approach
A three-dimensional transient groundwater flow model (modular finite difference groundwater FLOW model: MODFLOW) was used to simulate the impacts of three climate scenarios (i.e. an average of a long-term rainfall, predicted rainfall in 2015-2030 and three years moving average rainfall) on groundwater recharge and groundwater levels. Various climate scenarios in Long Ashton Research Station Weather Generator were applied to predict weather data.

Findings
HadCM3 climatic model and A2 emission scenario were selected as the best methods for weather data generation. Based on the results of these models, annual precipitation will decrease by 3 per cent during 2015-2030. For three emission scenarios, i.e. an average of a long-term rainfall, predicted rainfall in 2015-2030 and three years moving average rainfall, precipitation in 2030 is estimated to be 265, 257 and 247 mm, respectively. For the studied aquifer, predicted recharge will decrease compared to recharge calculated based on the average of long-term rainfall.

Originality/value
The decline of groundwater level in the study area was 11.45 m during the past 24 years or 0.48 m/year. Annual groundwater depletion should increase to 0.75 m in the coming 16 years via climate change. Climate change adaptation policies in the basin should include changing the crop type, as well as water productivity and irrigation efficiency enhancement at the farm and regional scales.
Barriers and challenges to international interactions of the faculty members in Iran
Authors: Nazarzadeh Zare Mohsen , Pourkarimi Javad , Rezaeian Sahba 
Published: April 2018

PurposeThe purpose of this paper is to identify the barriers and challenges to international interactions of the faculty members in Iran.Design/methodology/approachTo achieve the purpose, a qualitative phenomenological approach was used. The research population was all experts in the field of higher education in Iran, it included 17 experts who were selected through purposeful sampling by snowball method and based on theoretical saturation. To collect the data, a semi-structured interview was used and for the data analysis, an inductive content analysis was applied.FindingsThe findings showed that the barriers and challenges to faculty members’ international interactions can be defined through three main barriers: inside university barriers, outside university barriers, and individual barriers.Practical implicationsThis research identified the barriers and challenges of faculty members’ international interactions in Iran. The method of this study can be applied in other applied fields as well.Originality/valueThis study adds to the authors’ knowledge about international interactions of the faculty members and also the barriers and challenges of these interactions, so to have more interactions of faculty members at the international level, universities should make an effort to identify barriers and eliminate them, more than ever.
University performance evaluation and strategic mapping using balanced scorecard (BSC)
Authors: Alani Farooq Salman , Khan M. Firdouse Rahman , Manuel Diana F. 
Published: April 2018

Purpose
The purpose of this paper is to analyze and explore the effectiveness of using balanced scorecard (BSC) as a management tool in the evaluation of the performance and thereby the quality services of a University.

Design/methodology/approach
The survey was conducted among the various faculties and departments Sohar University through a well-defined questionnaire. The collected primary data were compiled, analyzed and a critical analysis was carried out using a null hypothesis, χ2, and regression analysis.

Findings
Our empirical result clearly reveals that there is a strong association exists between the strategic road map and the four perspectives of BSC.

Research limitations/implications
The study was carried out in Sohar University, Oman and the same can be extended to all the higher educational institutions globally.

Practical implications
The study reveals that the key performance measures identified under the classification the four perspectives of BSC, play a crucial role in establishing the framework based on the strategic map determined by the vision and the mission of the University.

Social implications
The study demonstrates that the BSC concept can be introduced to an educational institution to fill up the gap created between the creation of strategy and implementation of the same.

Originality/value
No study has investigated the performance evaluation of a higher education institution in Oman, using the four perspectives of BSC, and this is a first hand study.
Use of social media, student engagement, and academic performance of business students in Malaysia
Authors: Alshuaibi Mohammad Said Ibrahim , Alshuaibi Ahmad Said Ibrahim , Shamsudin Faridahwati Mohd. , Arshad Darwina Ahmad 
Published: April 2018

Purpose
Social media is a popular communication tool for college students in many countries including Malaysia. Even though the literature indicates that the use of social media in a higher learning environment is likely to enhance academic performance of college students, the mechanism that explains such association is yet to be explored. Based on the claims that the integration of social media use is purposeful to enhance student engagement, the purpose of this paper is to investigate the role of student engagement as a potential mediator between social media use and academic performance of college students in Malaysia.

Design/methodology/approach
A total number of 227 business students in one of the public universities in Malaysia were randomly chosen to participate in this study. Questionnaire was used as the main data collection technique, which was personally administered during class sessions. Data were analyzed using structural equation modeling-partial least square (SEM-PLS).

Findings
The result showed the multidimensionality of student engagement. It also indicated that cognitive engagement mediated the relationship between social media and academic performance, but not behavioral, emotional, or agentic engagement. The result suggests that social media has the potential to be used in a learning environment as it promotes cognitive engagement of students in class and subsequently their academic performance and success.

Research limitations/implications
One of the limitations of the present study is that the generalizability of the finding to a much larger population of students may be limited as the sampled students were recruited from business students in one of the public universities in Malaysia only. Students of different academic programs in different universities may have a different pattern of using the social media.

Practical implications
This study will help higher learning institutions and educators think of ways to integrate the use of social media in learning activities to help students achieve better academic performance. As shown by the findings, such use can encourage students to be cognitively engagedt in class in which the students can be more active learners.

Originality/value
The present study adds to the literature in social media use by addressing the issue of how it helps enhance academic performance of college students in a single model. Past studies tended to examine the role of social media and student engagement and the effect of student engagement on academic performance separately. Furthermore, this study took into consideration various types of social media used by college students who tend to have multiple accounts.
The potential of computer-mediated internships for higher education
Authors: Bayerlein Leopold , Jeske Debora 
Published: April 2018

Purpose
The purpose of this paper is to discuss the opportunities and limitations of computer-mediated internships (CMIs) for higher education providers (HEPs) and to outline how HEPs may maximize the benefits that arise from CMIs through strategic choices.

Design/methodology/approach
The paper provides a systematic assessment of the benefits, opportunities and limitations of CMIs. A particular focus of the paper concerns ways in which HEPs may utilize CMIs to maximize student learning as well as institutional benefits in terms of the use of expertise, collaborations and the achievement of institutional targets.

Findings
Benefits of CMIs include the more inclusive access of previously disadvantaged student groups to internship opportunities, as well as fewer restrictions for HEPs and employers. Given the right design, CMIs can provide a number of important learning opportunities to students while providing extensive opportunities for HEPs. However, the benefits of CMIs need to be viewed in line with the challenges that arise, such as the skill and expertise required to implement CMIs, the required investment of resources, and the currently limited acceptance of CMIs by employers.

Practical implications
The findings of the paper highlight that CMIs have the potential to be highly beneficial for HEPs and students. In addition, the paper showcases how HEPs may address the limitations of traditional internships, as well as the challenges that arise in relation to CMIs, through the systematic and well supported application of technological solutions.

Originality/value
The paper makes an important contribution to the literature because it is the first to evaluate the potential of CMIs for the providers of higher education programs.
Executive pensions, compensation leverage, and firm risk
Authors: White Reilly 
Published: April 2018

Purpose
The purpose of this paper is to investigate how the structure of both CEO and non-CEO executive compensation affects the overall risk of a firm. The author focuses on the interplay between CEO and non-CEO executive compensation structure.

Design/methodology/approach
The author uses a hand-collected pension-database that employs both OLS and two-stage least squares regressions to determine the effects of inside debt on default risk using the distance-to-default framework. The database consists of 8,965 executive-year data points from 272 firms.

Findings
This paper accomplishes three major objectives: first, the author presents a significant extension of Sundaram and Yermack (2007) by including non-CEO executives; the author demonstrates how the differences in inside debt between CEO and non-CEO executives are directly related to firm risk; and that funding these pensions via a Rabbi Trust eliminates most of the risk-shifting effects. Firms with the lowest compensation leverage gap between CEO and non-CEO executives were most likely to observe the agency costs associated with high executive leverage. When compensation leverage structures were substantially different, or the pension was pre-funded, these effects are neutralized.

Originality/value
To the best of the author’s knowledge, the first paper addresses the effects of Rabbi Trusts on risk-shifting behavior between both CEOs and non-CEO executives. Further, the author extends Sundaram and Yermack (2007) using a hand-collected database six times larger than the original paper. By focusing on the “leverage gap” between CEOs and non-CEO executives, the author presents unique evidence that underlines the risk dynamics between CEOs and their boards.