bluuebunny/crossref_metadata_2025_split huggingface dataset:
The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens
Authors: Clarke Fiona , Purvis Harriet A. , Sanchez-Blanco Cristina , Gutiérrez-Martinez Enrique , Cornish Georgina H. , Zamoyska Rose , Guermonprez Pierre , Cope Andrew P. 
Published: August 2018

AbstractA C1858T single nucleotide polymorphism within PTPN22 (which encodes PTPN22R620W) is associated with an enhanced susceptibility to multiple autoimmune diseases including type 1 diabetes and rheumatoid arthritis. Many of the associated autoimmune diseases have an autoantibody component to their pathology. Fc receptors (FcRs) recognise autoantibodies when they bind to autoantigens and form immune complexes. After immune complex binding and receptor crosslinking, FcRs signal via Src and Syk family kinases, leading to antigen uptake, presentation and cytokine secretion. Ptpn22 encodes a protein tyrosine phosphatase that negatively regulates Src and Syk family kinases proximal to immunoreceptor signalling cascades. We therefore hypothesised that PTPN22 regulates immune complex stimulated FcR responses in dendritic cells (DCs). Bone marrow derived DCs (BMDCs) from wild type (WT) or Ptpn22−/− mice were pulsed with ovalbumin:anti-ovalbumin immune complexes (ova ICs). Co-culture with WT OT-II T cells revealed that ova IC pulsed Ptpn22−/− BMDCs have an enhanced capability to induce T cell proliferation. This was associated with an increased capability of Ptpn22−/− BMDCs to present immune complex derived antigens and to form ova IC dependent DC-T cell conjugates. These findings highlight PTPN22 as a regulator of FcR mediated responses and provide a link between the association of PTPN22R620W with autoantibody associated autoimmune diseases.
Urine neutrophil gelatinase–associated lipocalin predicts outcome and renal failure in open and endovascular thoracic abdominal aortic aneurysm surgery
Authors: Gombert A. , Prior I. , Martin L. , Grommes J. , Barbati M. E. , Foldenauer A. C. , Schälte G. , Marx G. , Schürholz T. , Greiner A. , Jacobs M. J. , Kalder J. 
Published: August 2018

AbstractUrine neutrophil gelatinase–associated lipocalin (uNGAL) has been evaluated as a biomarker for AKI detection and adverse outcome in open and endovascular thoracoabdominal aortic aneurysm surgery. This observational, retrospective study included 52 patients. UNGAL was measured peri-operatively (48 h) and correlated with AKI requiring dialysis, tracheotomy and adverse outcome. Mean patients’ age was 64.5 years. A total of 26.9% (n = 14) developed AKI, and 21.1% (n = 11) required dialysis, tracheotomy rate was 19.2% (n = 10) and in-hospital mortality rate was 7.6% (n = 4). uNGAL levels were related to AKI requiring dialysis at ICU (p = 0.0002), need for tracheotomy at baseline and admission on ICU (p = 0.0222, p = 0.0028, respectively), as well as adverse discharge modality (p = 0.0051, p = 0.0048, respectively). Diagnostic quality was good for uNGAL levels at admission to ICU regarding AKI requiring dialysis (sensitivity: 81.8% [48.2–97.7]; specificity: 87.8% [73.8–95.9]; area under the curve (AUC): 0.874 [0.752–0.949]). The diagnostic quality of uNGAL was favorable for the prediction of tracheotomy (sensitivity: 70.0% [34.8–93.3]; specificity: 83.3% [68.6–93.0]; AUC: 0.807 [0.674–0.903]) and adverse discharge (sensitivity: 77.8% [40.0–97.2]; specificity: 83.7% [69.3–93.2]; AUC: 0.817 [0.685–0.910]). uNGAL may be valuable as an post-operative predictor of AKI and adverse outcome after open and endovascular TAAA repair.
Preparation and surface modification of magnesium hydroxide in a cetyltrimethyl ammonium bromide/isopropanol/cyclohexane/water microemulsion
Authors: Wu Haihong , Zhao Xu , Wang Licong , Ma Laibo , Huang Xiping 
Published: August 2018

A scalable technique for controlled synthesis and surface modification of magnesium hydroxide using the microemulsion method at room temperature was studied. The magnesium hydroxide nucleation and growth were carried out in numerous identical nanoreactors formed by cetyltrimethyl ammonium bromide/isopropanol/cyclohexane/water microemulsion. The crystal structure, morphology, thermostability and surface performance of the product as flame‐resistant material were investigated by X‐ray diffraction, scanning electron microscopy, thermogravimetry/differential scanning calorimetry, fourier transform infrared spectroscopy and dispersion tests. The results indicated that the product had a flake structure and belonged to a hexagonal system, the highly defined nanoflakes had a uniform diameter, and the diameter size can be well controlled in the range of 40–65 nm by adjusting the ratio of water to surfactant. The thermostability analyses showed a narrowed decomposition temperature range. Furthermore, the surfactant in microemulsion was adsorbed on the particles surface, making the surface of magnesium hydroxide changed from hydrophilic to lipophilic. Therefore the reported magnesium hydroxide material has a better flame resistance and compatibility with polymer materials than conventional magnesium hydroxide.
Revisiting the pre-main-sequence evolution of stars
Authors: Kunitomo Masanobu , Guillot Tristan , Ida Shigeru , Takeuchi Taku 
Published: August 2018

Aims. We want to investigate how planet formation is imprinted on stellar surface composition using up-to-date stellar evolution models.Methods. We simulate the evolution of pre-main-sequence stars as a function of the efficiency of heat injection during accretion, the deuterium mass fraction, and the stellar mass,M⋆. For simplicity, we assume that planet formation leads to the late accretion of zero-metallicity gas, diluting the surface stellar composition as a function of the mass of the stellar outer convective zone. We estimate that in the solar system, between 97 and 168M⊕of condensates formed planets or were ejected from the system. We adopt 150M⊕(M⋆/M⊙)(Z/Z⊙) as an uncertain but plausible estimate of the mass of heavy elements that is not accreted by stars with giant planets, including our Sun. By combining our stellar evolution models to these estimates, we evaluate the consequences of planet formation on stellar surface composition.Results. We show that after the first ~0.1 Myr during which stellar structure can differ widely from the usually assumed fully convective structure, the evolution of the convective zone follows classical pre-main-sequence evolutionary tracks within a factor of two in age. We find that planet formation should lead to a scatter in stellar surface composition that is larger for high-mass stars than for low-mass stars. We predict a spread in [Fe/H] of approximately 0.05 dex for stars with a temperature ofTeff~ 6500 K, to 0.02 dex for stars withTeff~ 5500 K, marginally compatible with differences in metallicities observed in some binary stars with planets. Stars withTeff≤ 7000 K may show much larger [Fe/H] deficits, by 0.6 dex or more, in the presence of efficient planet formation, compatible with the existence of refractory-poorλBoo stars. We also find that planet formation may explain the lack of refractory elements seen in the Sun as compared to solar twins, but only if the ice-to-rock ratio in the solar-system planets is less than ≈0.4 and planet formation began less than ≈1.3 Myr after the beginning of the formation of the Sun.
Qualitätsmanagement – Wissensmanagement in der Endoskopie
Authors: Meick Ira 
Published: August 2018

ZusammenfassungQualitätsmanagement im Krankenhaus ist in der heutigen Zeit nichts Neues mehr. Es handelt sich beim Qualitätsmanagement generell um einen sich stetig verändernden Prozess, der nur durch ständige Optimierung und Anpassung – im Sinne eines kontinuierlichen Verbesserungsprozesses (KVP) – an den stetigen Wandel der gesetzlichen, wissenschaftlichen und betriebswirtschaftlichen Voraussetzungen seine volle Wirkung entfalten kann.
Inflammatory Response 24 h Post-Exercise in Youth with Juvenile Idiopathic Arthritis
Authors: Rochette Emmanuelle , Merlin Etienne , Hourdé Christophe , Evrard Bertrand , Peraira Bruno , Echaubard Stephane , Duché Pascale 
Published: August 2018

AbstractThe aim of this study was to measure the impact, at 24 h post-exercise, of a single exercise bout on plasma inflammatory markers such as calprotectin, IL-6, sIL-6 R, sgp130 and the hypothalamic-pituitary-adrenal (HPA) axis in children with juvenile idiopathic arthritis (JIA).Twelve children with JIA attended the laboratory on three consecutive days (control day, exercise day and 24 h post-exercise), including a 20-min exercise bout on a cycle-ergometer at 70% of max. HR at 8:30 a.m. on day 2. Plasma concentrations of calprotectin, IL-6, sIL-6 R, sgp130, cortisol, ACTH and DHEA were measured on venous blood samples taken every day.at rest and at 8:30, 8:50, 9:30, 10:30 a.m. and 12:00, 3:00, 5:30 p.m.A single exercise bout increased plasma calprotectin 1.7-fold (p<0.001) but did not increase IL-6 and soluble IL-6 receptors in short-term post-exercise recovery. However, at 24 h post-exercise, calprotectin, IL-6 and its receptors had decreased compared to control-day levels. There was a transient 2-fold increase in post-exercise self-evaluated pain (p=0.03) that disappeared in the evening without repercussions the following day.Physical activity in children with JIA results in a slight transient systemic inflammation but seems to be followed by counter-regulation at 24 h post-exercise with a decrease in proinflammatory markers.
Changes in Ulnar Variance after a Triangular Fibrocartilage Complex Tear
Authors: Shim Jung-In , Im Jin-Hyung , Kang Han-Vit , Cho Sung-Hyun , Lee Joo-Yup 
Published: August 2018

Purpose The relationship between triangular fibrocartilage complex (TFCC) tear and ulnar impaction syndrome has not been fully understood. We hypothesized that a TFCC tear could change the ulnar variance, which may be the cause of ulnar impaction syndrome.
Patients and Methods A total of 72 patients who underwent TFCC foveal repair between January 2011 and June 2016 were included in this retrospective study. Among them, 44 patients diagnosed with TFCC foveal tear with distal radioulnar joint instability and no ulnar impaction syndrome underwent TFCC foveal repair only (group A) and 28 patients diagnosed with TFCC foveal tear with ulnar impaction syndrome underwent TFCC foveal repair and ulnar shortening osteotomy simultaneously (group B). We measured their ulnar variances in preoperative, postoperative, and last follow-up plain radiography. We also compared them with the ulnar variance of the contralateral (uninjured) wrist. Postoperative clinical outcomes, such as range of motions of the wrist, the visual analog scale (VAS) for pain, grip strength, and Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) score, were assessed.
Results Ulnar variance increased after TFCC tears compared with that on the uninjured side in both groups (group A: 0.98 vs. 0.52 mm, p = 0.013; group B: 2.71 vs. 2.13 mm, p = 0.001). Once the TFCC was repaired, ulnar variance decreased (group A: 0.98 to 0.01 mm, p < 0.01; group B: 2.71 to 0.64 mm, p < 0.01). However, it was increased on the last follow-up radiograph (group A: 0.01 to 0.81 mm, p < 0.01; group B: 0.64 to 1.05 mm, p = 0.004). There were no significant improvement of range of motion, except for pronation–supination motion (p = 0.04). Mean grip strength increased from 56.8 to 70.8% of the contralateral unaffected hand at the last assessment (p = 0.01). Mean VAS for pain decreased from 7.4 ± 2.5 preoperatively to 2.7 ± 2 postoperatively (p = 0.001). The QuickDASH score significantly improved from 45 to 9 (p = 0.001).
Conclusion Ulnar variance may be changed after a TFCC tear. In our study, it decreased after TFCC foveal repair. However, as time went on, the ulnar variance increased again, which could be one of the causes of ulnar impaction syndrome and ulnar-sided wrist pain.
Level of Evidence This is a therapeutic Level IV study.
Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells
Authors: Darnell Max , O’Neil Alison , Mao Angelo , Gu Luo , Rubin Lee L. , Mooney David J. 
Published: August 2018

Significance
Cells have been shown to respond to a host of physical properties of the environments that surround them. However, given that these properties vary considerably across tissues, how these individual properties interact to form unique regulatory environments for cells is largely unknown. This work analyzes the transcriptional responses of cells to unique combinations of microenvironmental material properties to gain broad insights into the coupling among different properties, the magnitude of the transcriptional effects, and the role of cell type. We find significant coupling among these properties, large variation in the magnitude of the transcriptional changes, and qualitative differences in the responses based on cell type, demonstrating the significant context dependence of microenvironmental material sensing.
Redox-coupled quinone dynamics in the respiratory complex I
Authors: Warnau Judith , Sharma Vivek , Gamiz-Hernandez Ana P. , Di Luca Andrea , Haapanen Outi , Vattulainen Ilpo , Wikström Mårten , Hummer Gerhard , Kaila Ville R. I. 
Published: August 2018

Significance
Complex I is the primary energy-converting enzyme of aerobic respiratory chains. By reducing quinone to quinol, this gigantic enzyme pumps protons across its membrane domain, which in turn powers ATP synthesis and active transport. Despite the recently resolved molecular structures of complex I, the quinone dynamics and its coupling to the pumping function remains unclear. Here we show by large-scale molecular simulations that the quinone reduction leads to ejection of the quinol molecule from the active site into a second binding site near the proton-pumping membrane domain of complex I. The identified region has been linked with human mitochondrial disorders. Our work suggests that the quinone dynamics provides a key coupling element in complex I.
Weed biological control in the Greater Mekong Subregion: status and opportunities for the future.
Authors: Day M. D. , ShiCai Shen , GaoFeng Xu , FuDou Zhang , Winston R. L. 
Published: August 2018

Abstract

The status of weed biological control in the six Greater Mekong Subregion (GMS) countries was assessed, and opportunities to develop biological control in the region are proposed. Twenty biological control agents targeting nine weed species have been introduced into GMS countries, with 13 agents establishing on seven weed species. Another nine biological control agents have spread unintentionally into the region. These agents are having a slight to high impact on their target weeds. However, the number of weeds in the region that have been targeted for biological control is only a fraction of the number of weeds (45) in the region that have been targeted for biological control elsewhere. This presents a tremendous opportunity to expand weed biological control in the region and reduce the dependency on herbicides while increasing productivity. There are numerous highly effective biological control agents present elsewhere that could be introduced to assist with the management of the region's most important weeds, such as
Pistia stratiotes
,
Salvinia molesta
,
Chromolaena odorata
and
Mikania micrantha
. Along with the introduction of biological control agents, there is also a scope to increase the capacity and training in biological control within GMS countries to develop effective weed control and management.
Constructing a Second Language Sociolinguistic Repertoire: A Sociocultural Usage-based Perspective
Authors: Van Compernolle Rémi A 
Published: August 2018

Abstract
This article discusses a sociocultural usage-based perspective on the development of sociolinguistic competence. Previous research has focused on learners’ acquisition and use of alternative ways of ‘saying the same thing’ (i.e. native-like variation) in relation to study abroad, contact with native speakers, and pedagogy. Missing from the literature are studies examining the developmental trajectories of individual learners from a qualitative perspective. This article takes a first step in this direction by documenting the specific lexicogrammatical constructions deployed by one learner of French, Leon, over the course of a 6-week stylistic variation intervention. The findings show that his sociolinguistic repertoire emerged from a single multiword expression, which in combination with Leon’s application of new metalinguistic knowledge and mediation from a teacher expanded to become a more productive schematic template. The research suggests that future work on L2 sociolinguistic development would do well to focus on qualitative accounts of individual developmental trajectories, emphasizing the specific lexicogrammatical constructions learners appropriate, to understand how L2 sociolinguistic repertoires are constructed across time.
Increased sensitivity with automated validation of XL-MS cleavable peptide crosslinks
Authors: Keller Andrew , Chavez Juan D , Bruce James E 
Published: August 2018

AbstractMotivationPeptides crosslinked with cleavable chemical crosslinkers are identified with mass spectrometry by independent database search of spectra associated with the two linked peptides. A major challenge is to combine together the evidence of the two peptides into an overall assessment of the two-peptide crosslink.ResultsHere, we describe software that models crosslink specific information to automatically validate XL-MS cleavable peptide crosslinks. Using a dataset of crosslinked protein mixtures, we demonstrate that it computes accurate and highly discriminating probabilities, enabling as many as 75% more identifications than was previously possible using only search scores and a predictable false discovery rate.Availability and implementationXLinkProphet software is freely available on the web at http://brucelab.gs.washington.edu.Supplementary informationSupplementary data are available at Bioinformatics online.
Costs and Their Predictors in Transsphenoidal Pituitary Surgery
Authors: Asemota Anthony O , Ishii Masaru , Brem Henry , Gallia Gary L 
Published: August 2018

Abstract

BACKGROUND
Contemporary surgical approaches to pituitary pathologies include transsphenoidal microsurgical and, more recently, endoscopic techniques. Data reporting direct costs in transsphenoidal pituitary surgery are limited.

OBJECTIVE
To examine direct costs (including overall total, hospital/facility, and physician payments) of microscopic and endoscopic pituitary surgery and evaluate predictors of differential costs in transsphenoidal pituitary surgery using a national database.

METHODS
The Truven MarketScan® database 2010-2014 (IBM, Armonk, New York) was queried and patients undergoing microscopic and/or endoscopic transsphenoidal pituitary surgery identified. Mean costs and predictors of differential costs were analyzed using analysis of variance and generalized linear models. Beta-coefficients (β) assessed relative contributions of independent predictors.

RESULTS
Mean overall total ($34 943.13 [SD ± 19 074.54]) and hospital/facility ($26 505.93 [SD ± 16 819.52]) payments were higher in endoscopic compared to microscopic surgeries (both P < .001). Lengths of hospital stay (LOS) were similar between groups. Predictors of overall total and hospital/facility payments were similar including surgical technique, age, geographical region, comorbidity index, postoperative surgical and medical complications, and LOS with LOS being the most significant predictor (β = 0.27 and β = 0.29, respectively). Mean physician payments ($4549.24 [SD ± 3956.27]) were similar in microscopic and endoscopic cohorts (P = .26). Predictors of physician payments included age, health plan, geographical region, postoperative surgical complications, and LOS with health plan being the most significant predictor (β = –0.21).

CONCLUSION
Higher overall total and hospital/facility costs are associated with endoscopic transsphenoidal pituitary surgery compared to microsurgery. In contrast, physician reimbursements are similar between techniques. Whereas LOS was the strongest predictor of overall total and hospital/facility costs, health plan was the strongest predictor of differential physician reimbursements.
Near-Infrared Optical Contrast of Skull Base Tumors During Endoscopic Endonasal Surgery
Authors: Jeon Jun W , Cho Steve S , Nag Shayoni , Buch Love , Pierce John , Su YouRong S , Adappa Nithin D , Palmer James N , Newman Jason G , Singhal Sunil , Lee John Y K 
Published: August 2018

Abstract

BACKGROUND
Near-infrared (NIR) tumor contrast is achieved through the “second-window ICG” technique, which relies on passive accumulation of high doses of indocyanine green (ICG) in neoplasms via the enhanced permeability and retention effect.

OBJECTIVE
To report early results and potential challenges associated with the application of second-window ICG technique in endonasal endoscopic, ventral skull-base surgery, and to determine potential predictors of NIR signal-to-background ratio (SBR) using endoscopic techniques.

METHODS
Pituitary adenoma (n = 8), craniopharyngioma (n = 3), and chordoma (n = 4) patients received systemic infusions of ICG (5 mg/kg) approximately 24 h before surgery. Dual-channel endoscopy with visible light and NIR overlay were photodocumented and analyzed post hoc.

RESULTS
All tumors (adenoma, craniopharyngioma, chordoma) demonstrated NIR positivity and fluoresced with an average SBR of 3.9 ± 0.8, 4.1 ± 1.7, and 2.1 ± 0.6, respectively. Contrast-enhanced T1 signal intensity proved to be the single best predictor of observed SBR (P = .0003). For pituitary adenomas, the sensitivity, specificity, positive predictive value, and negative predictive value of NIR-guided identification of tumor was 100%, 20%, 71%, and 100%, respectively.

CONCLUSION
In this preliminary study of a small set of patients, we demonstrate that second-window ICG can provide NIR optical tumor contrast in 3 types of ventral skull-base tumors. Chordomas demonstrated the weakest NIR signal, suggesting limited utility in those patients. Both nonfunctional and functional pituitary adenomas appear to accumulate ICG, but utility for margin detection for the adenomas is limited by low specificity. Craniopharyngiomas with third ventricular extension appear to be a particularly promising target given the clean brain parenchyma background and strong SBR.