bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote consequences of prematurity: violations of physical development and eating behavior of children and adolescents
Authors: Rafikova Ju. S. , Podporina M. A. , Saprina T. V. , Loshkova E. V. , Mikhalev E. V. , Stolyarova V. A. , Nagaeva T. A. , Agarkova L. A. , Мikheenko G. A. 
Published: July 2018

Aim. To characterize the physical development (PD) and eating behavior (EB) of children and adolescents born prematurely.Materials and methods. The study involved 123 people born in the period 1997-2008, 58 children born prematurely, age (12 ± 1.3) years, gestation period (33.07 ± 1.9) weeks (main group). The control group consisted of 65 full-term peers, age (12.7 ± 2.2) years, gestational age (39.5 ± 0.8) weeks. Participants were evaluated by PD (height, weight, body mass index (BMI), waist circumference (WC), throat circumference (TC)) under the WHO AnthroPlus program, and EB using the Dutch DEBQ questionnaire.Results. Growth and Z-score growth of boys and girls of the main group is lower than that of their fullterm peers, p = 0.04; 0.004 (p < 0.0001 for Z-score growth). Z-score BMI in boys and girls of the main group is higher than in full-term, p = 0.04; 0.01. WC/TC the girls of the main group is higher than in fullterm peers, p < 0.0001. In premature boys, the restrictive type is 13.3%, emotional and external – 50%, the combination of emotional and external – 33.3%. In the control restrictive – 5,7%, emotional – 28,6%, external – 32,3%, the combination of emotional and external – 10,8%, the combination of all three types – 5,7%. In the group of premature girls restrictive –7.1% against 36.7% in the control, (p = 0.007), emotsiogenic – 10.7% against 36.6% of the control (p = 0.02), external – 10.3% against 60% of the control (p = 0.003). In the control group the combination of external and emotiogenic – 16.7% (in the primary group is 0, p = 0.02). Preterm boys emotiogenic and external and their combination more often than girls (p = 0.001; 0.02; 0.001).Conclusion.Children and adolescents born prematurely are below full-term peers and have a high z-score of BMI. Boys realize violations of external and emotional types, and their combination.
Obesity in mothers and metabolic disorders in both mothers and children: possible influences
Authors: Smetanina S. A. , Suplotova L. A. , Khramova E. B. , Girsh Y. V. 
Published: July 2018

Aim. To study the relationship between obesity of the mother, the body weight of the newborn and the formation of metabolic disturbances in subsequent periods of life.Materials and methods. A prospective study was conducted in which 1,000 women of reproductive age and their newborns were included by the random number method. The mean age is 29.5 [25.0; 33.5] years. The examination included the collection of anamnesis, measurement of body height and body weight, blood pressure, waist circumference and body mass index determination. Micro- and macrosomia in term infants was diagnosed with a birth weight less than 15 and more than 97 percentiles (WHO, 2005). The laboratory study included the determination of glucose, cholesterol, triglycerides, high and low density lipoproteins, insulin and C-peptides of basal and stimulated levels, leptin, adiponectin, determination of insulin resistance indices (HOMA-IR) and pancreatic β-cell function (HOMA-β). The statistical analysis of the material was carried out using the Statistica 10 software package, SPSS 13.0. Statistically significant differences were taken into account at a level of p < 0.05.Results. It was found that when pregnancy occurs, 41.0% of women are overweight or obese. In the study, the pathological mass of the body in the neonatal period was detected in every fourth newborn (24.8%), including microsomia (11.3%) and macrosomia (13.5%). As a result, differences in the body weight of newborns were found, depending on the maternal pregestational BMI. For example, women with obesity of the first degree were more likely to have children with macrosomia in 33.3% of cases than women with normal body weight, whose incidence of children with macrosomia was detected in 12.0% of cases (OR 6.8; 95% CI 2.66–17.56; p < 0.001). In women in the reproductive period, macrosomia at birth was more characteristic for people with a metabolic syndrome, and was associated with hormone-metabolic changes.Conclusion. Тhe results demonstrate the effect of pre-gestational body weight in women with obesity on the body weight of offspring at birth. Both macrosomia and microsomia at birth can be risk factors for the development of the metabolic syndrome in the long term, which confirms the importance of preventing overweight and obesity in women of childbearing age in the pre-gestational period.
Novel Chemical Method for Decreasing of Toxicity of Highly Cytotoxic Amidoximes by Introduction of Benzo[4,5]imidazo[2,1-b]thiazolyl Fragment
Authors: Abele Edgars , Abele Ramona , Golomba Lena , Domracheva Ilona , Beresneva Tatjana , Jaschenko Elina , Gulbe Anita 
Published: July 2018

Aims and Objectives: The aim of the research is to obtain and to investigate the cytotoxicity of a
novel class of non-toxic oximes – derivatives of N-(benzo[4,5]imidazo[2,1-b]thiazol-3-ylmethoxy)-ω-
(hetarylsulfanyl)-alkanamidines.

Materials and Methods:
To assess the possible toxicity of the compounds, acute oral LD50 was calculated.
The calculations were based on tested compounds IC50 values in relation to 3T3 (mouse fibroblast cell line)
using NRU assay. Monolayer tumor cell lines HT-1080 (human fibrosarcoma, ATCC® CCL-121™), MH-22A
(mouse hepatoma, ECACC code, 96121721) and NIH/3T3 (mouse Swiss Albino embryo fibroblasts, ATCC®
CRL-1658™), were cultured in standard medium (Dulbecco`s modified Eagle`s medium) supplemented with
10% fetal bovine serum (“Sigma”).

Results:
E-Stereoselective synthesis of novel N-(benzo[4,5]imidazo[2,1-b]thiazol-3-ylmethoxy)-ω-
(hetarylsulfanyl)alkanamidines as potential cytotoxic agents was carried out in three steps from corresponding
thiones. N-(Benzo[4,5]imidazo[2,1-b]thiazol-3-ylmethoxy)-5-(benzothiazol-2-ylsulfanyl)-pentanamidine exhibits
high activity in vitro on the monolayer tumour cell lines: MG-22A (mouse hepatoma) and HT-1080
(human fibrosarcoma). Besides this, the above compound exhibits low toxicity on the 3T3 cell line and low
estimated acute oral LD50 (LD50 2759 mg/kg).

Conclusion:
In conclusion, such dramatic decreasing of expected acute toxicity and high cytotoxicity by the
introduction of benzo[4,5]imidazo[2,1-b]thiazolyl fragment into N-hydroxy-ω-(hetarylsulfanyl)alkanamidines
were demonstrated for the first time (see, for example, toxicity and cytotoxicity of compound 8b and corresponding
unsubstituted oxime).
In vitro Assessment of the Antibacterial and Antioxidant Properties of Essential Oils
Authors: Zardo Danianni M. , Alvarez Leydi V.H. , Los Francine G.B. , Ito Vivian C. , Travalini Ana P. , Cardoso Taís , Wojeicchoski José P. , Alberti Aline , Zielinski Acácio A.F. , Esmerino Luís , Nogueira Alessandro 
Published: July 2018

Background:
Outbreaks of foodborne diseases cause substantial economic losses. Universities,
research institutes and the food industry are increasing their efforts to enhance food safety worldwide.
In this context, the study of essential oils as natural antimicrobials and antioxidants for use in
foods has become increasingly important.

Methods:
The volatile composition and antioxidant and antibacterial activity of Pelargonium graveolens,
Cymbopogon citratus, Citrus bergamia, Rosmarinus officinalis and Mentha piperita essential oils
were evaluated.

Results:
The essential oils showed 80.5 to 95.0% of monoterpenes, but with different profiles. The free
radical scavenging activity by the DPPH assay ranged from 3.53 to 68.55% and the total antioxidant
potential measured by FRAP ranged from 1.28 to 94.61 mmol TE g-1. The antioxidant activity (FRAP
and DPPH assays) of the essential oils followed the order: C. citratus > M. piperita > P. graveolens > C.
bergamia > R. officinalis. In general, when the pH tended to neutrality a higher concentration of essential
oil was needed to inactivate the microorganisms. The C. citratus oil presented interesting results
regarding the inhibition of both strains of S. aureus, showing a lower MIC50 value and Minimum Bactericidal
Concentration (MBC) in the concentrations evaluated for E. coli and S. enterica.

Conclusion:
The results suggest that C. citratus essential oil has potential as an antibacterial and antioxidant
agent.
In Situ Oxidative Stress and Atrial Cell Deaths in Patients with Valve Disease
Authors: Matata Bashir M. , Elahi Maqsood M. 
Published: July 2018

Background:
Left ventricular hypertrophy and myocardial remodeling occur with aortic
valve disease and may lead to heart failure. Although increased oxidative stress and inflammatory
factors have been implicated in heart failure, their role in the progression of valve disease remains
unclear.
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Objectives: We investigated the role of oxidative stress and inflammatory factors in valve disease
whether this relates to cell death.

Methods:
Blood samples were taken from 24 patients with valve disease before surgery and the
results were compared with those from blood samples from 30 control healthy subjects. Myocardial
biopsies from patients with valve disease were also collected before cannulation of the right atrial
appendage. NF-κB activities in atrial and mononuclear cells nuclear extracts were determined by
electrophoretic mobility shift assay.

Results:
Nuclear factor kappaB activities were significantly greater in mononuclear cells from AVD
patients compared with healthy controls and the antigens were detectable in atrial tissues valve
disease patients. Plasma C-reactive protein, B-natriuretic peptides, plasma tumor necrosis factor
alpha and soluble tumor necrosis factor receptor 1 and 3-nitrotyrosine levels were significantly
higher in valve disease patients. Inducible nitric oxide and 3-nitrotyrosine antigens and cells
expressing CD45 antigens were detected within atrial tissues obtained from valve disease patients
suggesting oxidative stress originated from in situ leukocytes.

Conclusion:
The findings suggest that oxidative stress originating from in situ leukocytes within
the atrial myocardium may be the potential trigger for excessive transcriptional activities and
apoptotic cell death within the atrial myocardium of valve disease patients. This represents a
potential therapeutic target.
Development of a Path to Home Mobile App for the Geriatric Rehabilitation Program at Bruyère Continuing Care: Protocol for User-Centered Design and Feasibility Testing Studies
Authors: Backman Chantal , Harley Anne , Peyton Liam , Kuziemsky Craig , Mercer Jay , Monahan Mary Anne , Schmidt Sandra , Singh Harvinder , Gravelle Deborah 
Published: July 2018

Background
As the population ages, the need for appropriate geriatric rehabilitation services will also increase. Pressures faced by hospitals to reduce length of stay and reduce costs have driven the need for more complex care being delivered in the home or community setting. As a result, a multifaceted approach that can provide geriatric rehabilitation patients with safe and effective person- and family-centered care during transitions from hospital to home is required. We hypothesize that a technology-supported person- and family-centered care transition could empower geriatric rehabilitation patients, engage them in shared decision making, and ultimately help them to safely manage their personalized needs during care transitions from hospital to home.

Objective
The purpose of this study is to design and test the feasibility of a novel Path to Home mobile app to manage the personalized needs of geriatric rehabilitation patients during their transitions from hospital to home.

Methods
This study will consist of (1) codesigning a patient- and provider-tailored mobile app, and (2) feasibility pilot testing of the mobile app to manage the needs of geriatric rehabilitation patients when leaving the hospital. In phase 1, we will follow a user-centered design process integrated with a modern agile software development methodology to iteratively codesign the personalized care transition Path to Home mobile app. In phase 2, we will conduct a single-arm feasibility pilot test with geriatric rehabilitation patients using the personalized care transition Path to Home mobile app to manage their needs during the transition from hospital to home.

Results
The project was funded in May 2018, and enrollment and data analysis are underway. First results are expected to be submitted for publication in 2019.

Conclusions
Our findings will help validate the use of this technology for geriatric rehabilitation patients discharged from the hospital to home. Future research will more rigorously evaluate the health and economic benefits to inform wide-scale adoption of the technology.

Registered Report Identifier
RR1-10.2196/11031
Usability and Acceptability of a Text Message-Based Developmental Screening Tool for Young Children: Pilot Study (Preprint)
Authors: Johnson Pamela Ryden , Bushar Jessica , Dunkle Margaret , Leyden Sharon , Jordan Elizabeth T 
Published: July 2018

BACKGROUND

Only 30% of parents of children aged 9-35 months report that their child received a developmental screening in the previous year. Screening rates are even lower in low-income households, where the rates of developmental delays are typically higher than those in high-income households. Seeking to evaluate ways to increase developmental screening, Text4baby, a national perinatal texting program, created an interactive text message-based version of a validated developmental screening tool for parents.

OBJECTIVE

This study aimed to assess whether a text message-based developmental screening tool is usable and acceptable by low-income mothers.

METHODS

Low-income mothers of infants aged 8-10 months were recruited from the Women, Infants and Children Program clinics in Prince George’s County, MD. Once enrolled, participants used text messages to receive and respond to six developmental screening questions from the Parents’ Evaluation of Developmental Status: Developmental Milestones. After confirming their responses, participants received the results and feedback. Project staff conducted a follow-up phone survey and invited a subset of survey respondents to attend focus groups. A representative of the County’s Infants and Toddlers Program met with or called participants whose results indicated that their infants “may be behind.”

RESULTS

Eighty-one low-income mothers enrolled in the study, 93% of whom reported that their infants received Medicaid (75/81). In addition, 49% of the mothers were Hispanic/Latina (40/81) and 42% were African American (34/81). A total of 80% participated in follow-up surveys (65/81), and 14 mothers attended focus groups. All participants initiated the screening and responded to all six screening questions. Of the total, 79% immediately confirmed their responses (64/81), and 21% made one or more changes (17/81). Based on the final responses, 63% of participants received a text that the baby was “doing well” in all six developmental domains (51/81); furthermore, 37% received texts listing domains where their baby was “doing well” and one or more domains where their baby “may be behind” (30/81). All participants received a text with resources for follow-up. In a follow-up survey reaching 65 participants, all respondents said that they would like to answer screening questions again when their baby was older. All but one participant would recommend the tool to a friend and rated the experience of answering questions and receiving feedback by text as “very good” or “good.”

CONCLUSIONS

A mobile text version of a validated developmental screening tool was both usable and acceptable by low-income mothers, including those whose infants “may be behind.” Our results may inform further research on the use of the tool at older ages and options for a scalable, text-based developmental screening tool such as that in Text4baby.
Notas para la historia de la educación de la mujer durante el virreynato. Colegio de niñas de Oaxaca, Oaxaca
Authors: Muriel Josefina 
Published: July 2018

<p>El clérigo Juan Díaz que había ido en la expedición de Francisco de Orozco y el mercedario fray Bartolomé de Olmedo en la de Pedro de Alvarado, sólo se habían ocupado de la predicación superficial que se daba a los caciques en ocasiones como ésas, tras los contactos militares y pacíficos que por breve tiempo se tenía con ellos. Pero a la llegada de fray Gonzalo Lucero, O. P., y fray Bernardino de Minaya, O. P., se empezó a dar a los indios una instrucción religiosa más profunda, aplicando a ello los métodos misionales que el propio fray Alonso había desarrollado, como era un sistema audiovisual a base de cuadros en los que se presentaban los atributos de Dios como por ejemplo: Dios todopoderoso creador y sostenedor del universo, Dios justo y misericordioso, etcétera, Cristo redentor y después el modo de vivir conforme a la enseñanza del Evangelio. </p>
James Lockhart, The Nahuas After the Conquest. A Social and Cultural History of the Indians of Central México. Sixteenth Through Eighteenth Centuries
Authors: Ruiz Medrano Ethelia , Herrera María del Carmen 
Published: July 2018

Reseña sobre James Lockhart, The Nahuas After the Conquest. A Social and Cultural History of the Indians of Central México. Sixteenth Through Eighteenth Centuries, Stanford, Stanford University Press, 1992.
DRUG APPROVAL PROCESS: A CONTRASTIVE APPROACH
Authors: Kashyap Pankaj , Duggal Eshant , Budhwaar Vikaas , Nanda Dr. Arun , Badjatya Jitendra Kumar 
Published: July 2018

The drug approval process is the vehicle through which drug sponsors formally approve a new pharmaceutical for sale and marketing. The goals of the approval process are to provide enough information about the drug safety and efficacy in human beings. Every country has its own regulatory authority, which is responsible to enforce the rules and regulations and issue the guidelines to regulate the marketing of the drugs. The approval process starts with preclinical testing. For drugs that appear safe, an investigational new drug application (IND) is filed. If approved, clinical trials begin with phase 1 study that focus on safety and pharmacology. Phase 2 studies examine the effectiveness of the compound. Phase 3 is the final step before submitting a new drug application to the authority. A New Drug Application (NDA) contains all the information obtained during all phases of testing. Phase 4 studies, or post-marketing studies, are conducted after a product is approved.
EKSTRAKSI DAN PENENTUAN GUGUS FUNGSI ASAM HUMAT DARI PUPUK KOTORAN SAPI
Authors: Nurlina Nurlina , Syahbanu Intan , Tamnasi Mirna Tersiana , Nabela Chyntia , Furnata Maria Desi 
Published: July 2018

Cow manure fertilizer was used as raw material for the extraction of humic acid in this research. The aim of this research were extraction of humic acid from cow manure fertilizer, characterization of functional groups based on FTIR spectra, and determination of humic acid functional groups. Humic acid extraction from cow manure used 0.050 M; 0.100 M; 0.250 M dan 0.500 M KOH solution. A cow manure fertilizer were shaken with KOH solution for 1; 2; 4 and 6 h. The quantitative determination of oxygen-containing functional groups of humic acid was conducted by titrimetri. The FTIR spectrum showed the presence of –OH group and N-H stretching (bands 3361.46 cm-1); C-H aliphatic for CH2, CH3 (2946.52 cm-1 and 1442.24 cm-1); C=C aromatic components (1626.48 cm-1); COO- symmetric stretching (1521.71 cm-1); C-O stretching from –COOH (1229.74 cm-1). Total acidity value was 500 cmole.kg-1 (Baryta Absorption Method); carboxyl groups content was 250 cmole.kg-1 (Ca-Acetate Method); and phenol (OH) concentration was 250 cmole.kg-1. It can be concluded that humic acid successfully extracted from cow manure fertilizer using 0.250 KOH solution as extractant for 2 h, which has yield of 4.486% humic acid.
Малоинвазивная диагностика случайно обнаруженных кистозных процессов поджелудочной железы
Authors: Азаб Хуссейн Ахмад 
Published: July 2018

Кисты поджелудочной железы (КП) часто обнаруживаются случайно при ультразвуковом исследовании. Клинические проявления не выражены. Однако КП имеют риск злокачественности.
В данном обзоре рассмотрены критерии для клинической диагностики КП, роль трансабдоминальной ультрасонография, включая УЗИ с контрастным усилением, эндоскопического ультразвукового исследования (эUS) и КТ.
эUS имеет наибольшее значение в дифференциальной диагностике и прогностической характеристике случайно выявленной КП. В одном исследовании можно выполнить УЗИ с высоким разрешением, эUS, а также тонкоигольную аспирацию содержимого кисты, стенки кисты и её солидных компонентов. Критерии высокого риска при оценке муцинозных кист поджелудочной железы, в основном, базируются на результатах эUS и КТ. Тем не менее, несмотря на диагностический прогресс и улучшение визуализационных параметров, дифференциальная диагностика и определение тактики лечения остаются сложными. В этом обзоре будут обсуждаться проблемы и подходы к диагностике случайно выявленных КП.
СОЦИАЛЬНО-ЭКОНОМИЧЕСКОЕ РАЗВИТИЕ РЕСПУБЛИКИ ДАГЕСТАН
Authors: Рамазанов Джабраил Омарович , Асриянц Каринэ Геннадьевна 
Published: July 2018

Цель работы. Целью работы является исследование социально-экономического развития Республики Дагестан. Проводился анализ отрицательных сторон и прогноз развития на будущий год. Метод и методология проведения работы. Исследование основывается на общенаучной методологии, которая предусматривает применение системного подхода к решению проблем. Основой данной статьи послужили отечественные и зарубежные авторы работ, а также интернет-ресурсы. Результаты. Изучается вопрос социально-экономического развития регионов на примере Республики Дагестан, приоритетных направлений политики государства в отношении регионов, изучены основные факторы устойчивого развития региона, рассмотрен вопрос о переходе к новой экономической системе путем глубокого реформирования государственного регулирования регионального развития. Статья посвящена выявлению ключевых проблем, сдерживающих социальное и экономическое развитие региона Республики Дагестан. В статье обосновано двойственное влияние теневой экономики на динамику агрегированных показателей регионального социально-экономического развития. Рассмотрены вопросы поиска оптимального баланса в рамках межбюджетных отношений, путь к которому для России, в отличие от западноевропейских стран, должен быть иным с учетом размеров и степени освоенности территории. Существующие различия в экономических, социальных, природно-климатических, географических и экологических условиях регионов России определяют необходимость поиска оптимальных путей противодействия кризисным явлениям в наиболее проблемных сферах каждого субъекта Российской Федерации. Область применения результатов. Результаты могут быть использованы в действующих условиях Республики Дагестан, социально-экономические отношения которой преимущественно выполняют функции институционального развития, где показатели характеризуются положительной динамикой (снижение уровня безработицы, приток капитала, увеличение совокупных расходов и др.). Выводы: в настоящее время для того, чтобы развивать все виды экономической деятельности, необходимо проводить исследования и максимально продвигать развитие структуры занятости населения региона в промышленности, которое напрямую воздействует на социально-экономическое положение субъектов Российской Федерации. Обосновывается необходимость развития и формирования устойчивого развития региональной экономики и решение действующих проблем. В статье после выявленных факторов названы некоторые возможные мероприятия, направленные на преодоление сдерживающего влияния.