bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disability Consciousness on the Frontlines of Urban Struggle
Authors: Hande Mary Jean 
Published: November 2018

AbstractDrug wars, austerity and gentrification are interwoven social relations in many North American urban centres and are typically met with organising of varying degrees of militancy. Loïc Wacquant characterises many of these sites as highly stigmatised, associated with violence and pathology. In Toronto's downtown east end (DEE), one such stigmatised urban space, disabled activists are far from unfortunate casualties. They tend to refer to the DEE as an “urban battleground”, where disabled people politicise and challenge the DEE's pathology and stigma by linking into emerging radical disability politics across the global North and by developing localised revolutionary disability consciousness. Drawing on oral stories, zines and blogs of disabled activists and workers in Toronto's DEE, this article uses Rachel Gorman's dialectic of disability/disablement to analyse the emergence of revolutionary disability consciousness and the centrality of disabled people on the frontlines of anti‐gentrification and harm reduction organising in Toronto's DEE.
Hypertension induced by serotonin reuptake inhibitors: analysis of two pharmacovigilance databases
Authors: Humbert Xavier , Fedrizzi Sophie , Chrétien Basile , Sassier Marion , Bagheri Haleh , Combret Sandrine , Drici Milou‐Daniel , Le Bas François , Puddu Paolo E. , Alexandre Joachim 
Published: November 2018

AbstractDrug‐induced hypertension was described with several pharmacological classes, especially with serotonin reuptake inhibitors (SRIs). However, this link has remained controversial: the French summary of product characteristics specify a risk of hypertension only with paroxetine and sertraline. To identify a possible class effect common to all SRIs, our study investigated the reports of hypertension associated with SRIs in two pharmacovigilance databases. Two different types of investigations were performed: (i) a comparative study in VigiBase®, which is the World Health Organization (WHO) pharmacovigilance database (PVDB), from where notifications of hypertension with six SRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) were extracted. The relationship between the suspected SRIs and the occurrence of hypertension was assessed by calculating reporting odds ratio (ROR) in a case/non‐case design; (ii) a descriptive study of hypertension reports associated with SRIs in the French pharmacovigilance database (FPVDB). In VigiBase®, 14 824 notifications of SRI‐induced hypertension (2.5%) were identified (mean age 54.3 years, mainly women 69.1%). Among them, 3 879 (26.2%) were associated to sertraline; 3 118 (21.0%) to fluoxetine; 2 725 (18.4%) to paroxetine; 2 570 (17.3%) to citalopram; 2 295 (15.5%) to escitalopram; and 237 (1.6%) to fluvoxamine. A significant ROR value was found with all six SRIs (ROR range from 1.16 to 1.92). In the FPVDB, 24 reports of hypertension were found with all six SRIs used at standard doses, mainly in women (66.7%) with a mean age of 57.8 years and a median time of onset of 6 days. In 10 cases (42%), patients had a history of hypertension. This study, performed in real conditions of life, shows a significant pharmacovigilance safety signal between the use of SRIs and the development or worsening of hypertension.
Change in number of potentially inappropriate medications impacts on the nutritional status in a convalescent rehabilitation setting
Authors: Kose Eiji , Hirai Toshiyuki , Seki Toshiichi 
Published: November 2018

AimThe association between potentially inappropriate medications (PIM) use and nutritional status is unclear in Japan. The aim of the present study was to establish whether PIM use during hospitalization affects the nutritional status among geriatric patients in the convalescing stage.MethodsThis retrospective longitudinal cohort study included consecutive geriatric patients admitted and discharged from convalescent rehabilitation wards between 2010 and 2016. Participants were divided based on the presence or absence of increased PIM from admission to discharge. Demographic data, laboratory data and the Functional Independence Measure were analyzed between groups. We used the 2015 American Geriatrics Society Beers Criteria to screen for PIM, and the primary outcome was the Geriatric Nutritional Risk Index at discharge. A multiple linear regression analysis was used to examine whether Geriatric Nutritional Risk Index at discharge was independently associated with increased PIM.ResultsIn total, 643 participants (220 men, 423 women; interquartile range 73–85 years) were included in the present study. Multiple linear regression analysis for increased PIM, adjusting for confounding factors, showed that PIM use was independently and negatively correlated with Geriatric Nutritional Risk Index at discharge. In particular, first‐generation antihistamine, antipsychotic, benzodiazepine, proton pump inhibitor and non‐steroidal anti‐ inflammatory drug use increased significantly from admission to discharge.ConclusionsIncreased PIM might be a predictor of nutritional status in geriatric patients. Geriatr Gerontol Int 2019; 19: 44–50.
Biocontrol of saprolegniosis in rainbow trout (Oncorhynchus mykiss Walbaum) using two bacterial isolates (LE89 and LE141) of Pseudomonas fluorescens
Authors: González‐Palacios Concepción , Fregeneda‐Grandes Juan‐Miguel , Aller‐Gancedo José‐Miguel 
Published: November 2018

AbstractThe probiotic activity of 15 bacterial isolates that inhibit Saprolegnia parasitica in vitro was tested for the biocontrol of saprolegniosis in rainbow trout (Oncorhynchus mykiss Walbaum), adding the bacteria to tank water for 14 days at a concentration of 106 bacteria ml−1 water. Pseudomonas fluorescens LE89 and Pseudomonas fluorescens LE141 were effective in controlling experimental infection with S. parasitica since of the fish treated with LE89, 24.5% ± 16.27% (p < 0.05) became infected, as did 42.8% ± 8.41% (p < 0.05) of those treated with LE141. Given their protective effect when administered in water, their effect was also studied when administered in feed before and after experimental infection. Both bacterial isolates survived low pH levels and the action of bile, grew in skin and intestinal mucus, were resistant to several antibiotics and survived in feed; however, neither of the two isolates prevented S. parasitica infection when administered in feed.
How Do Central Bank Governors Matter? Regulation and the Financial Sector
Authors: MISHRA PRACHI , RESHEF ARIELL 
Published: November 2018

AbstractDo past employment characteristics of central bank governors affect financial regulation? To answer this question, we construct a new data set based on curriculum vitae of all central bank governors around the world in 1970–2011. We interpret work experiences as indicators of preferences toward deregulation. Over the average duration in office (5.6 years), a governor with financial sector experience is associated with three times more deregulation than a governor without experience in finance. Similar results hold for past experience at the IMF; in contrast, past experience at the BIS and the UN are associated with less deregulation.
Two sisters with a rare cause of infantile colic
Authors: Negm Yasser 
Published: November 2018

IntroductionInfantile colic is a major parenthood challenge. For medical practitioners, even at the highest specialised levels, the management is never less challenging. This is a case report of two sisters who presented with typical symptoms of infantile colic. However, after a lengthy journey of workups, they were found to have a rare cause of those symptoms, requiring surgical repair.Presenting historyA female baby born at term was initially diagnosed to have infantile colic. As the symptoms did not improve at the age of 3 months, she was referred to a paediatrician who switched her formula based on a provisional diagnosis of cows milk protein intolerance. With no relief of the baby's symptoms, this diagnosis was ruled out. Empirical treatment of gastro‐oesophageal reflux was attempted. After the failure of this attempt, it was decided that the child's condition needs to be thoroughly investigated.ProgressOver 6 years, comprehensive investigations and relevant referrals at a tertiary paediatric gastroenterology centre have not helped to establish a definitive diagnosis or aetiology of the colic. Dietary modifications and various empirical medications have failed to cure the episodes, which exhausted the family, waking them up 10–20 times every night, leading to poor school attendance.TreatmentA suggestion during a multidisciplinary meeting made a turning point. Definitive diagnosis and repair were established via laparoscopic surgery.Follow‐upThe child fully recovered following the surgical repair. Her sister, who was born with the same condition, was fortunate to be diagnosed and cured at a younger age.
Monitoring Taiwanese bovine arboviruses and non‐arboviruses using a vector‐based approach
Authors: Tzeng H.‐Y. , Wu H.‐H. , Ting L.‐J. , Chang N.‐T. , Chou Y.‐C. , Tu W.‐C. 
Published: November 2018

AbstractIn current sampling approaches, there exists a divergence between the surveillance of arthropod‐borne and that of non‐arthropod‐borne viruses. It is commonly held that the collection of vector specimens applies only to arbovirus surveillance and that the surveillance of non‐arboviruses must rely on traditional methods that involve the sampling of blood, faeces or saliva, or other examinations. The vector‐based approach is a sampling method that has the ability to survey both arboviruses and non‐arboviruses by distinguishing engorged vector specimens from entire vector samples. Accordingly, five arboviruses and three non‐arboviruses were detected in a study using a vector‐based approach conducted during 2012–2015. Hence, this report provides the first description of the Taiwanese vector species for the bovine arboviruses detected. The present investigations demonstrate that the vector‐based approach applies not only to the surveillance of arboviruses, but also has potential as a possible tool for monitoring non‐arboviruses on livestock farms in the future.
Facing a Liturgy-Starved Church: Do We Need to Think Afresh About the Basics of Ministry?
Authors: O'Loughlin Thomas 
Published: November 2018

AbstractThe Catholic Church cannot, at present, find sufficient clergy to staff its parishes and this is provoking a massive pastoral, and so a liturgical, reorganization. However, these changes are not primarily driven by the demography of the actual churches, communities of people, but are solely the result of a decline in clerical numbers. Most attempts to deal with this turn on seeking to increase the number of deployable persons in presbyterial orders (e.g. seeking clergy from Africa or India), making a wider use of deacons, and scaling up the size of liturgical communities, irrespective of the nature of that liturgy, so that areas are ‘covered.’ But this assumes that actual communities, when gathered for the eucharist, are a function of the number of clergy; but surely the number of ministers is secondary to the location and size of the communities who are in need of ministry? This paper seeks to ask fundamental questions about the nature of liturgical ministry in keeping with the conference's theme of ‘who ministers what to whom?’ What is the basis of liturgical ministry? Does it exist independently of a worshipping community? Is it primarily as an individual's ‘vocation’ to ‘be a priest’, who then ministers, or a community need provided from within that community in union with the larger church? This ‘bottom up’ approach affects how we see not only actual liturgical ministry, but the priesthood of the Christ, the priesthood of all the baptized, and our pneumatology of vocation within actual churches.
The impact of implementing an educational intervention to enhance a family‐oriented approach in specialised palliative home care: A quasi‐experimental study
Authors: Petursdottir Asta B. , Haraldsdottir Erna , Svavarsdottir Erla Kolbrun 
Published: November 2018

RationaleHealthcare providers’ beliefs, attitudes, experiences and knowledge, which guide the care they deliver, are the key factors influencing the quality of palliative care. Education and coaching innovation are needed to translate research outcomes and adopt evidence‐based nursing care into practice.ObjectivesTo evaluate the impact of an advanced educational and coaching programme in a family systems’ nursing approach for palliative care nurses in a home‐care setting.MethodsA quasi‐experimental study using qualitative data from open‐ended questions to augment the quantitative outcome study that included a single‐group, pre‐ and post‐test design. A total population sample of nurses was recruited from a specialised palliative home care unit at a university hospital. The study utilised two self‐reported questionnaires.ResultsThere was a statistically significant increase in the nurses’ critical appraisal of clinical nursing practice related to family nursing after participation in the educational programme than before. No statistical difference was found in items related to nurses’ experience of the interaction and reciprocity in the nurse–family relationship after participation in the programme than compared to before or in nurses’ cancer‐related beliefs. However, there was an overall significant positive change found in attitudes towards families in the total score of the Family Practice Scale. Nurses were also more positive about the further development of their knowledge and skills in advanced family nursing evident in the qualitative data.ConclusionAn advanced educational intervention programme was successful in improving the nurses’ knowledge, skills, satisfaction and confidence in relation to applied family nursing approach within the context of caring for families affected by advanced/final stage cancer. However, further refinement of the implementation process is needed to enhance family care improvement and the nurses’ professional development in advanced family nursing in specialised palliative care.
Agreement of surgical blood loss estimation methods
Authors: Jaramillo Sebastian , Montane‐Muntane Mar , Capitan David , Aguilar Ferran , Vilaseca Antoni , Blasi Annabel , Navarro‐Ripoll Ricard 
Published: November 2018

BACKGROUNDSurgical blood loss is usually estimated by different formulae in studies of strategies aimed at reducing perioperative bleeding. This study assessed and compared the agreement of the main blood loss estimation formulae using a direct measurement of blood loss as the reference method.STUDY DESIGN AND METHODSEighty consecutive patients undergoing urologic laparoscopic surgery were studied. Only optimal conditions for the direct measurement of surgical blood loss were considered. Surgical blood loss was estimated by six formulae at four different postoperative time points. The agreement of the formulae was evaluated by the Concordance correlation coefficient (CCC) and Bland–Altman analyses. An analysis of the agreement's variability regarding different magnitudes of blood loss was also performed.RESULTSDirectly measured blood loss ranged from 200 to 2200 mL. The formulae studied showed poor agreement with the direct measurement of blood loss; 95% limits of agreement widely exceeded the criterion of ±560 mL. Significant biases were found, which for most of the formulae led to an overestimation of blood loss. For all formulae, agreement remained constant regardless of the amount of blood loss, with limits between −40 and +120% approximately. Among the formulae, the best agreement was achieved by López‐Picado's formula at 48 hours (CCC: 0.577), with a bias of +283 mL and 95% limits of agreement between −477 and +1043 mL.CONCLUSIONFormulae currently used to estimate surgical blood loss differ substantially from direct measurements; therefore, they may not be reliable methods of blood loss quantification in the surgical setting.
Inhibition of non‐receptor tyrosine kinase Src induces phosphoserine 256‐independent aquaporin‐2 membrane accumulation
Authors: Cheung Pui W. , Terlouw Abby , Janssen Sam Antoon , Brown Dennis , Bouley Richard 
Published: November 2018

Key points
Aquaporin‐2 (AQP2) is crucial for water homeostasis, and vasopressin (VP) induces AQP2 membrane trafficking by increasing intracellular cAMP, activating PKA and causing phosphorylation of AQP2 at serine 256, 264 and 269 residues and dephosphorylation of serine 261 residue on the AQP2 C‐terminus.
It is thought that serine 256 is the master regulator of AQP2 trafficking, and its phosphorylation has to precede the change of phosphorylation state of other serine residues.
We found that Src inhibition causes serine 256‐independent AQP2 membrane trafficking and induces phosphorylation of serine 269 independently of serine 256.
This targeted phosphorylation of serine 269 is important for Src inhibition‐induced AQP2 membrane accumulation; without serine 269, Src inhibition exerts no effect on AQP2 trafficking.
This result helps us better understand the independent pathways that can target different AQP2 residues, and design new strategies to induce or sustain AQP2 membrane expression when VP signalling is defective.
AbstractAquaporin‐2 (AQP2) is essential for water homeostasis. Upon stimulation by vasopressin, AQP2 is phosphorylated at serine 256 (S256), S264 and S269, and dephosphorylated at S261. It is thought that S256 is the master regulator of AQP2 trafficking and membrane accumulation, and that its phosphorylation has to precede phosphorylation of other serine residues. In this study, we found that VP reduces Src kinase phosphorylation: by suppressing Src using the inhibitor dasatinib and siRNA, we could increase AQP2 membrane accumulation in cultured AQP2‐expressing cells and in kidney collecting duct principal cells. Src inhibition increased exocytosis and inhibited clathrin‐mediated endocytosis of AQP2, but exerted its effect in a cAMP, PKA and S256 phosphorylation (pS256)‐independent manner. Despite the lack of S256 phosphorylation, dasatinib increased phosphorylation of S269, even in S256A mutant cells in which S256 phosphorylation cannot occur. To confirm the importance of pS269 in AQP2 re‐distribution, we expressed an AQP2 S269A mutant in LLC‐PK1 cells, and found that dasatinib no longer induced AQP2 membrane accumulation. In conclusion, Src inhibition causes phosphorylation of S269 independently of pS256, and induces AQP2 membrane accumulation by inhibiting clathrin‐mediated endocytosis and increasing exocytosis. We conclude that S269 can be phosphorylated without pS256, and pS269 alone is important for AQP2 apical membrane accumulation under some conditions. These data increase our understanding of the independent pathways that can phosphorylate different residues in the AQP2 C‐terminus, and suggest new strategies to target distinct AQP2 serine residues to induce membrane expression of this water channel when VP signalling is defective.
Effectiveness of online interventions in preventing depression: a protocol for systematic review and meta-analysis of randomised controlled trials
Authors: Rigabert Alina , Motrico Emma , Moreno-Peral Patricia , Resurrección Davinia M , Conejo-Cerón Sonia , Navas-Campaña Desirée , Bellón Juan Á 
Published: November 2018

IntroductionAlthough evidence exists for the efficacy of psychosocial interventions in preventing depression, little is known about its prevention through online interventions. The objective of this study is to conduct a systematic review and meta-analysis of randomised controlled trials assessing the effectiveness of online interventions in preventing depression in heterogeneous populations.Methods and analysisWe will conduct a systematic review and meta-analysis of randomised controlled trials that will be identified through searches of PubMed, PsycINFO, WOS, Scopus, OpenGrey, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and Australia New Zealand Clinical Trials Register . We will also search the reference lists provided in relevant studies and reviews. Experts in the field will be contacted to obtain more references. Two independent reviewers will assess the eligibility criteria of all articles, extract data and determine their risk of bias (Cochrane Collaboration Tool). Baseline depression will be required to have been discarded through standardised interviews or validated self-reports with standard cut-off points. The outcomes will be the incidence of new cases of depression and/or the reduction of depressive symptoms as measured by validated instruments. Pooled standardised mean differences will be calculated using random-effect models. Heterogeneity and publication bias will be estimated. Predefined sensitivity and subgroup analyses will be performed. If heterogeneity is relevant, random-effect meta-regression will be performed.Ethics and disseminationThe results will be disseminated through peer-reviewed publication and will be presented at a professional conference. Ethical assessment is not required as we will search and assess existing sources of literature.Trial registration numberCRD42014014804; Results.
Acceptance and commitment therapy (ACT) for adult type 1 diabetes management: study protocol for a randomised controlled trial
Authors: Amsberg Susanne , Wijk Ingrid , Livheim Fredrik , Toft Eva , Johansson Unn-Britt , Anderbro Therese 
Published: November 2018

IntroductionIntegrating diabetes self-management into daily life involves a range of complex challenges for affected individuals. Environmental, social, behavioural and emotional psychological factors influence the lives of those with diabetes. The aim of this study is to evaluate the impact of a stress management group intervention based on acceptance and commitment therapy (ACT) among adults living with poorly controlled type 1 diabetes.Methods and analysisThis study will use a randomised controlled trial design evaluating treatment as usual (TAU) and ACT versus TAU. The stress management group intervention will be based on ACT and comprises a programme divided into seven 2-hour sessions conducted over 14 weeks. A total of 70 patients who meet inclusion criteria will be recruited over a 2-year period with follow-up after 1, 2 and 5 years.The primary outcome measure will be HbA1c. The secondary outcome measures will be the Depression Anxiety Stress Scales, the Swedish version of the Hypoglycemia Fear Survey, the Swedish version of the Problem Areas in Diabetes Scale, The Summary of Self-Care Activities, Acceptance Action Diabetes Questionnaire, Swedish Acceptance and Action Questionnaire and the Manchester Short Assessment of Quality of Life. The questionnaires will be administered via the internet at baseline, after sessions 4 (study week 7) and 7 (study week 14), and 6, 12 and 24 months later, then finally after 5 years. HbA1cwill be measured at the same time points.Assessment of intervention effect will be performed through the analysis of covariance. An intention-to-treat approach will be used. Mixed-model repeated measures will be applied to explore effect of intervention across all time points.Ethics and disseminationThe study has received ethical approval (Dnr: 2016/14-31/1). The study findings will be disseminated through peer-reviewed publications, conferences and reports to key stakeholders.Trial registration numberNCT02914496; Pre-results.