bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Characteristics Associated With Voluntary Safety Event Reporting in the Acute Care Setting
Authors: Thurtle Danielle P. , Daffron Sara B. , Halvorson Elizabeth E. 
Published: February 2019

OBJECTIVES:
Adverse events are increasingly important to health care delivery and financial reimbursement. Most hospitals use voluntary event reporting (VER) systems to detect safety events, which may be vulnerable to individual and systemic biases. We tested the hypothesis that patient demographic factors such as weight status and race would be associated with safety event reporting in the acute care setting.

METHODS:
We reviewed all acute care encounters for patients 2 to 17 years of age and corresponding safety events entered in the VER system of a tertiary-care children’s hospital from February 2015 to February 2016. Data collected included patient demographics, clinical characteristics, incident description, and reported harm score. Our primary outcome was any report of a safety event. Using χ2 and multivariable logistical regression methods, we determined patient characteristics associated with safety event reporting.

RESULTS:
A total of 22 056 patient encounters were identified, and 341 (1.5%) of those had a reported safety event. In univariate analysis, age, weight category, and race were found to be significantly associated with event reporting, whereas sex and insurance provider were not. In the multivariable logistic regression model, obesity (odds ratio [OR] 0.69; 95% confidence interval [CI] 0.49–0.97) and African American race (OR 0.65; 95% CI 0.46–0.93) were negatively associated with event reporting, whereas length of stay was positively associated (OR 1.51; 95% CI 1.46–1.55).

CONCLUSIONS:
We identified associations between patient demographic factors and voluntary safety event reporting in the acute care setting. In future studies, we will compare VER to event identification by more objective measures, such as a trigger tool.
Entrevista con Myriam Gutiérrez Correal
Authors: Leal Leal Gloria E. , Ramírez María Himelda 
Published: February 2019

Licenciada en Trabajo Social en la Universidad Nacional de Colombia; especialista en Técnicas Avanzadas de Investigación y Evaluación Social aplicadas a la Educación, en el Instituto Latinoamericano y del Caribe de Planificación Económica y Social (Ilpes) (Chile). Trabajó en el Departamento Nacional de Planeación (DNP) (1974 a 1994). Luego, con la Cooperación Técnica Alemana (GTZ) en el programa Proequidad (2001-2006); trabajó en el Instituto Interamericano de Cooperación para la Agricultura (IICA/CA). En 2006, se vinculó al programa Áreas de Desarrollo Alternativo Municipal (ADAM) de Associates in Rural Development (ARD). Ha sido asesora de la Asociación de Mujeres Campesinas, Negras e Indígenas de Colombia (Anmucic), de la Federación Departamental de Mujeres Campesinas de Cundinamarca (Fedemucc) y en ENDA Colombia-Organización en pro del medio ambiente-. Entre sus publicaciones figuran Una mirada de Género al sector rural colombiano (2003), Mujer, Semilla, Alimento, una mirada al sistema agroalimentario colombiano desde la Perspectiva de Género (1995) y el libro autobiográfico y testimonial La Última Mirada (2018). En 2006, obtuvo el Premio Nacional del IICA/OEA por su contribución al desarrollo de las Mujeres Rurales en Colombia; fue docente en los programas de Trabajo Social de la Universidad Católica de Chile (1972-1973), de la Universidad Nacional de Colombia (1999) y en el posgrado de Trabajo Social de la Universidad de la Salle (1999-2000).
Antibiotic susceptibility and ability to form biofilm of Listeria monocytogenes strains isolated from frozen vegetables
Authors: Skowron K. , Grudlewska K. , Lewandowski D. , Gajewski P. , Reśliński A. , Gospodarek-Komkowska E. 
Published: February 2019

L. monocytogenes poses a serious threat to public health, since most cases of listeriosis are connected with eating contaminated food. L. monocytogenes is often detected both in fresh and frozen vegetables.
The aim of this study was to evaluate the antibiotic susceptibility and ability to form biofilm of L. monocytogenes strains isolated from frozen vegetable mixtures in Poland.
Ninetynine genetically different strains were found among 100 isolates of L. monocytogenes. Among the 99 strains, 80 (80.8%) were susceptible to all tested antibiotics. Nineteen (19.2%) strains were resistant to one or more antibiotics. From this group of L. monocytogenes strains, most strains were resistant to erythromycin (16; 16,1%), penicillin (15; 15.1%), meropenem (12; 12.1%), cotrimoxazole (12; 12.1%), and ampicillin (3; 3.1%). According to the obtained results, differences in intensity of biofilm, both between those isolated in successive years and in the particular year, were observed. Performed analysis showed statistically insignificant faint negative correlation (r=–0.088) between the number of antibiotics to which strains were resistant and the intensity of biofilm formation by them.
Food contamination with L. monocytogenes poses a threat to consumers, therefore it is necessary to monitor their antibiotic susceptibility, ability to form biofilm, and genetic similarity, in order to evaluate the strains persistence time in plant.
Development of mathematical methods for calculation of the pubic arch angle
Authors: Mudrov Viktor A. , Mochalova Marina N. , Mudrov Andrey A. 
Published: February 2019

Hypothesis/aims of study. The frequency of adverse intranatal outcomes is significantly increased when the pubic arch angle (PAA) is less than 90°. The accuracy of the manual method for determining PAA depends on a large number of parameters, such as obesity of a woman, as well as stereometric sensation and the experience of a doctor. Determination of PAA using ultrasound and X-ray pelviometry is generally available and reliable; however, it requires special training. The aim of this study was to develop mathematical methods for calculation of PAA.
Study design, materials and methods. The study included a retrospective and prospective analysis of 120 birth histories based on the Regional Clinical Hospital Perinatal Center (the Chita city, the years 2017/2018), which were divided into three equal groups. Group 1 consisted of patients with body weight deficit, group 2 included patients with normal body mass index, and group 3 comprised patients with alimentary constitutional obesity. On the eve of the birth, external pelviometry, the manual method for determining PAA, and ultrasound pelviometry by translabial access were performed.
Results. PAA determined by the manual method was 99.6 ± 11.3° in group 1, 100.1 ± 14.2° in group 2, and 98.2 ± 10.7° in group 3. When ultrasound pelviometry was performed, the value of PAA was 97.4 ± 10.7° in group 1, 104.8 ± 13.8° in group 2, and 104.1 ± 12.3° in group 3. The error of the manual method was 2.2% in group 1, 4.5% in group 2, and 7.6% in group 3. On the basis of mathematical modeling of external pelviometry data, a pattern is defined, which is expressed by the formula: PAA = 180° – arccos (0,5 ∙ S1S2/S1P) – arccos (0,5 ∙ B1B2/(B2S1 – S1P), where PAA is the pubic arch angle (°); S1S2, Distantia spinarum; S1P, the distance between the anterior superior spine of the ilium to the lower edge of the symphysis; B2S1, the distance between the anterior superior spine of the ilium to the tuberosity of the opposite ischium; B1B2, the transverse size of the output plane. The coefficient of determination (R-squared) is 0.82. Thus, mathematical modeling allows determining PAA with a high degree of reliability.
Correction of immune disorders and changes in the protein/lipid spectrum of circulating erythrocyte membranes in adenomiosis
Authors: Ivanova Oksana Yu. , Telegina Olga V. , Konoplya Alexey A. , Rybnikov Vladimir N. 
Published: February 2019

Hypothesis/aims of study. Disorders of immune homeostasis, morphofunctional and ultrastructural changes of erythrocytes in endometriosis lead to hypoxia, impaired micro-rheological and hemostatic statuses, dysmetabolism, organ and system dysfunction, which may contribute to the systemic consequences of this disease. The aim of this study was to evaluate the immune status and protein/lipid spectrum of erythrocyte membranes, as well as to develop methods for the pharmacological correction of impaired parameters in patients with internal endometriosis.
Study design, materials, and methods. Fifty-seven patients with verified grade I–II adenomyosis were examined, assessing some immune status parameters and determining protein and lipid fractions of circulating erythrocyte membranes before and after pharmacotherapy.
Results. The changes in the immune status parameters and protein and lipid composition of erythrocyte membranes revealed in adenomiosis disrupt the functional activity of immunocompetent cells and erythrocytes.
Conclusion. The proposed methods of pharmacotherapy are pathogenetically substantiated and contribute to the correction of both the chosen immune status parameters and structural and functional properties of red blood cells, while improving the quality of treatment of patients with adenomyosis.
Surgical treatment satisfaction in women with pelvic organ prolapse. Quantification and analysis
Authors: Korshunov Mikhail Yu. , Sergeyeva Irina V. 
Published: February 2019

Hypothesis/aims of study. An integrated evaluation of the effectiveness of pelvic organ prolapse (POP) treatment in women requires a consistent interpretation of the criteria of treatment satisfaction. The aim of this study was to specify surgical treatment satisfaction in patients with POP.
Study design, materials, and methods. Surgical treatment was performed in 486 patients with POP stages II–IV. In 12 months, a patient survey (using a 1-5-point scale) evaluated the level of treatment satisfaction, reasons for lowered self-reported satisfaction, and respondents’ ambivalence regarding treatment results.
Results. One-year post-surgical treatment of POP stages 0–I are observed in 80.9% of patients. Full satisfaction (5 points) was self-reported by 61.1% of patients, 28.6% of patients indicated partial satisfaction (3–4 points), and 10.3% of patients indicated treatment dissatisfaction (1–2 points). Post-surgery stage of POP is weakly correlated with self-reported treatment satisfaction (r = –0.39; p < 0.0001). Most common reasons for lower self-reported satisfaction were the emergence of new issues, fear of pathology recurrence, urinary incontinence, and pain. Five patients (1.0%) indicated that their condition “became much worse” after the surgical treatment.
Conclusion. The treatment satisfaction range is variable. It is necessary to consider a variety of clinical, deontological, and psychological factors in the analysis of surgical POP treatment satisfaction spectrum.
Thrombodynamic method of evaluation of some hemostatic parametersin healthy pregnant women and in women with preeclampsia
Authors: Kuznik Boris I. , Zagorodnyaya Emma D. , Iozefson Sergey A. , Isakova Natalia V. 
Published: February 2019

Hypothesis/aims of study. During pregnancy, hypercoagulation develops and fibrinolysis is inhibited. These changes are particularly pronounced in pregnancy complicated by preeclampsia. The existing techniques to evaluate hemostasis are rather laborious and do not provide a complete information of the volume and density of the fibrin clot. We aimed to conduct comparative studies of the state of the hemostasis system by conventional test-tube and thrombodynamic methods in healthy non-pregnant women and in pregnant women who are suffering and are not suffering from preeclampsia.
Study design, materials, and methods. We examined 40 pregnant women aged 17–33 years (mean age 24.3 ± 3.2 years) at the gestational age of 35–39 weeks. In 18 women, pregnancy was complicated by preeclampsia. The control group consisted of 35 healthy women (mean age 25.1 ± 2.6 years). The thrombodynamic characteristics of the clot were evaluated using the T-2 Thrombodynamics Recorder device (GemaKor Ltd., Russia) using the following parameters: Tlag, clot growth delay; Vi, initial growth rate; Vs, steady growth rate; D, clot density; C30, the size of the main clot in the 30th minute.
Results. When evaluating the hemostasis system by the thrombodynamic method in healthy pregnant women and in women with preeclampsia compared with non-pregnant women, the onset time of clot formation was significantly reduced, the initial and steady rate of the clot appearance, as well as the clot density and the clot size being increased.
Conclusion. The method for evaluating thrombodynamic properties of the blood clot is objective and visual way to estimate hemostasis. It complements the coagulogram indices and gives a clear view of the hemostasis system.
APC-resistance as a possible predictor of recurrent thrombosis in women with Factor V Leiden
Authors: Nikolayeva Maria G. , Momot Andrey P. , Zaynulina Marina S. , Momot Ksenia A. , Yasafova Natalia N. 
Published: February 2019

Hypothesis/aims of study. The current analysis was undertaken to elucidate the role of Factor Va resistance to proteolytic cleavage by activated protein C in FVL(1691)GA female carriers in the development of acute and recurrent thromboses.
Study design, materials and methods. A prospective clinical cohort study of 1100 women of reproductive age was conducted, with the course and outcomes of 2,707 pregnancies analyzed. Two cohorts were specified: the main group consisted of 500 patients with FV(1691)GA genotype, and the control group consisted of 600 patients with FVL(1691)GG genotype.
Results. FVL(1691)GA genotype was significantly associated with the development of venous thromboembolic complications (VTEC) compared to FVL(1691)GG genotype (OR 9.3; p < 0.0001). Episodes of recurrent thrombosis during and outside of pregnancy were registered only in FVL(1691)GA patients (OR 5.7, p = 0.2). In all cases, at the time of the thrombotic event and during the period before the episode of acute or recurrent thrombosis, an APC resistance normalized ratio (NR) value was ≤ 0.49, with no episodes of VTEC registered with an APC resistance NR value ≥ 0.5.
Conclusion. Venous thromboses occur under the condition of expressed APC resistance with underlying FVL(1691)GA carriage. The APC resistance index can serve as an objective biochemical marker to determine the feasibility of thromboprophylaxis within the framework of personalized medicine.
Antihypertensive and vasoprotective effectiveness of the chronopharmacotherapy in patients with arterial hypertension after acute cerebrovascular accident
Authors: Skibitsky V. V. , Fendrikova A. V. , Opolskaya S. V. 
Published: February 2019

Aim. To evaluate the eﬀectiveness of combined antihypertensive chronopharmacotherapy and estimate the daily blood pressure profle (BP) parameters, such as: stiﬀness of the vascular wall and central aortic pressure in patients with arterial hypertension (AH) who underwent transient ischemic atack (TIA) or ischemic stroke (IS).Materials and methods. 235 patients with hypertension who underwent acute cerebrovascular accident were examined. Tere were 116 patients with TIA and 119 with IS. All patients were randomized in 4 groups according to regimen of antihypertensive drugs combination. Te 1st group (n = 59) included patients with AH, who underwent TIA and received indapamide retard 1.5 mg and valsartan 160 mg in the morning regiment of drug therapy. Te 2nd group (n = 57) included patients with AH, who underwent TIA and received indapamide retard 1.5 mg in the morning and valsartan 80 mg twice a day (morning and evening). Te 3rd group (n = 47) included patients with AH, who underwent IS and received indapamide retard 1.5 mg and valsartan at a dose of 160 mg in the morning. Te 4th group (n = 56) included patients with AH, who underwent IS and received indapamide retard 1.5 mg in the morning and valsartan 80 mg twice a day (morning and evening). Ambulatory blood pressure monitoring (ABPM), central aortic pressure (CAP) measurement and vessel wall stiﬀness values were evaluated before treatment and afer 12 months of therapy.Results.Before the start of combined antihypertensive chronopharmacotherapy, most of the parameters for ABPM, vessel wall stiﬀness values and CAP in groups 1 and 2, 3 and 4 were comparable. Achievement of the target level of BP afer 8 weeks of treatment, was signifcantly more ofen in groups with a double sartan therapy (group 2 and group 4) in compare with its single time application only in the morning hours (group 1 and group 3) (p<0.05). Statistically signifcant positive dynamics of the main values of the daily profle of blood pressure, stiﬀness of the vascular wall and central aortic pressure (p <0,05) were registered in all groups. However, more pronounced decline of main parameters of ABPM, stiﬀness of the vascular wall and central aortic pressure values were noted in group with double use sartan therapy in compare with single time sartan therapy in the morning time. (p <0.05). Signifcant positive dynamics of the main values of the ABPM, stiﬀness of the vascular wall and CAP were registered in patients who underwent IS and received double application sartan therapy (4th group) in compare with patients with TIA (2nd group) (p = 0.02).Conclusion.Double use sartan therapy, combined with a thiazide diuretics in patients, who underwent IS or TIA more ofen promotes to get target values of blood pressure, improve the main values of the ABPM, stiﬀness of the vascular wall and CAP in compare with single time sartan therapy in the morning time
КОМПЬЮТЕРНАЯ МОДЕЛЬ ПРИНЯТИЯ РЕШЕНИЙ ПО РЕКОНФИГУРАЦИИ СТРУКТУРЫ ТЕХНОЛОГИЧЕСКОЙ СИСТЕМЫ ИЗМЕЛЬЧЕНИЯ РУДЫ
Authors: (Seyran Sh. Balasanyan) Баласанян Сейран Шамирович , (Hermine M. Gevorgyan) Геворгян Эрмине Михайловна 
Published: February 2019

Актуальность исследования обусловлена необходимостью повышения надежности и эффективности функционирования технологической системы измельчения руды путем введения структурной избыточности. Цель: обоснование необходимости повышения эффективности функционирования технологической системы измельчения руды путем введения структурной избыточности (резервных связей), определение наилучшей структуры резервных связей между измельчительными агрегатами и рациональной стратегии их использования, построение математической модели принятия решений по реконфигурации (перестроении) структуры технологической системы измельчения руды при отказах ее оборудования в виде дерева решений, разработка компьютерной модели принятия решений по реконфигурации структуры технологической системы измельчения руды. Объект: технологическая система измельчения руды Зангезурского медно-молибденового комбината (Армения). Методы: метод дерева решений (метод мягких вычислений), имитационное моделирование. Результаты. В результате имитационных экспериментов с компьютерной модели технологической системы измельчения руды определена наилучшая структура резервных связей между измельчительными агрегатами и рациональная стратегия их использования, с применением которых построена математическая модель принятия решений по реконфигурации структуры технологической системы измельчения руды (при отказах ее оборудования) в виде дерева решений. На основе этой модели разработана компьютерная модель, позволяющая при изменении работоспособ­ности измельчительных агрегатов своевременно выбрать наилучшую для данной сложившей отказовой ситуации структуру и режим работы каждого агрегата, независимо от квалификации и опыта оператора. Благо­даря применению этой модели оператор полностью освобождается от обязанностей лица, принимающего решения. Разработанная компьютерная модель включена в состав специального программного обеспечения автоматизированной системы управления технологическим процессом измельчения руды Зангезурского медно-молибденового комбината (Армения).
ОПТИМИЗАЦИЯ ПРОЦЕССА ЗАКАЧКИ ФИКСИРОВАННЫХ ОБЪЕМОВ ЖИДКОСТИ В ДВА НАПРАВЛЕНИЯ
Authors: (Golia I. Bikbulatova) Бикбулатова Голия Ильдусовна , (Achmetsalim S. Galeev) Галеев Ахметсалим Сабирович , (Yulia A.Boltneva) Болтнева Юлия Анатольевна , (Petr A. Larin) Ларин Пётр Андреевич , Rais N. Suleymanov Сулейманов Раис Насибович , (Oleg V. Filimonov) Филимонов Олег Владимирович 
Published: February 2019

Представлен новый подход к решению задачи оптимизации работы динамической системы «насос+трубопроводная сеть». В статье состоянием процесса закачки называются объёмы жидкости, поступившие через каждый трубопровод в данный момент времени. Эти объёмы взяты в качестве основных функций, зависящих от времени и описывающих процесс закачки. Система функций определяет воображаемую линию – траекторию закачки в пространстве, задаваемом плановыми объёмами закачки через каждый трубопровод. Регулирование потока в трубопроводах любыми устройствами, создающими местное гидродинамическое сопротивление (устройствами) даёт возможность получать различные траектории. Влияние регулирующих устройств оценивается коэффициентом открытости трубопровода или потока, определяемым как отношение потока (расхода) в частично перекрытом трубопроводе к потоку в полностью открытом трубопроводе. Рассмотрены два варианта закачки, в которых продемонстрировано, что разным траекториям может соответствовать своя потребляемая энергия. Проведён анализ используемой при количественных исследованиях и оценке работы насоса величины, равной отношению напора, создаваемого насосом, к КПД, соответствующему этому напору. Показано, что при повышении напора или снижении подачи данная величина возрастает. Поскольку затрачиваемая насосом энергия зависит от формы траектории, энергия становится функционалом, для поиска минимума которого привлекаются методы вариационного исчисления. Таким способом находится экстремаль – траектория, на которой затраты энергии и времени минимальны. Траекторией, описывающей оптимальный режим закачки, оказывается прямолинейный отрезок в пространстве закачки, концы которого соответствуют начальному и конечному состояниям процесса закачки. Для реализации данного процесса предложен алгоритм, позволяющий определить, какой трубопровод следует частично перекрыть, и рассчитать меру перекрытия, рассматривая регулирующее устройство как устройство, задающее коэффициент местного сопротивления. Цель работы: определить оптимальный способ закачивания в два трубопровода, в котором насос и трубопроводная сеть рассматриваются как единая взаимосвязанная система. Объекты исследования: насосы, используемые для поддержания пластового давления, два трубопровода, снабжённых устройствами для регулирования расхода жидкости. Методы исследования: метод для нахождения оптимального режима – вариационное исчисление. Результаты. Работа насоса требует наименьшего количества энергии и времени, если заполнение заданных объёмов происходит одновременно. Для процесса экономичного закачивания в два трубопровода дан алгоритм определения степени перекрытия трубопроводов.