bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma Aβ analysis using magnetically-labeled immunoassays and PET 18F-florbetapir binding in non-demented patients with major depressive disorder
Authors: Wu Kuan-Yi , Hsiao Ing-Tsung , Chen Chia-Hsiang , Liu Chia-Yih , Hsu Jung-Lung , Huang Sheng-Yao , Yen Tzu-Chen , Lin Kun-Ju 
Published: February 2018

AbstractAn increased level of brain amyloid deposition and a decreased level of cerebral spinal fluid (CSF) Aβ42 are currently considered reliable biomarkers of Alzheimer’s disease (AD); however, the usefulness of plasma Aβ levels are not well-established. This study investigated the relationships between plasma Aβ levels and cerebral amyloidosis in 36 non-demented patients with major depressive disorder (MDD). All participants underwent 18F-florbetapir PET imaging and provided a blood sample at the same time for immunomagnetic reduction assay to measure the plasma levels of Aβ40 and Aβ42. We found inverse associations of the plasma Aβ42 level and the Aβ42/Aβ40 ratio, and a positive association of the plasma Aβ40 level, with cerebral amyloid deposition in the precuneus, parietal and posterior cingulate cortex. Subgroup analyses in subjects with higher 18F-florbetapir uptake values or MDD with amnestic mild cognitive impairment revealed more pervasive relationships of plasma Aβ measures with 18F-florbetapir binding across the brain regions examined. The study suggested that regional brain amyloid deposition in terms of 18F-florbetapir PET uptake had weak-to-moderate associations with plasma Aβ42 and Aβ40 levels, and the Aβ42/Aβ40 ratio. Validation in a larger population of subjects of known cerebral amyloidosis status is needed. Careful interpretation of plasma data is warranted.
Isolation and characterization of a minimal building block of polyubiquitin fibrils
Authors: Morimoto Daichi , Walinda Erik , Shinke Mayo , Sugase Kenji , Shirakawa Masahiro 
Published: February 2018

AbstractAs a posttranslational modifier, polyubiquitin is involved in the regulation of diverse intracellular processes; however, it is also found in pathological protein aggregates associated with Alzheimer’s disease and other neurodegenerative disorders. We previously observed that various types of polyubiquitin can form amyloid-like fibrils; however, the structural properties of these polyubiquitin fibrils have not been examined at an atomic level. Here we demonstrate that a soluble intermediate species can be extracted from disulfide-conjugated diubiquitin fibrils after cleaving the disulfide bonds in the fibrils. This newly discovered molecule is structurally and physicochemically distinguishable from native ubiquitin. In addition, it is thermodynamically metastable, as demonstrated by real-time NMR measurements. Collectively, our results suggest that the fibril-derived molecule is a minimal building block of polyubiquitin fibrils that reflects their structural and physicochemical properties.
Dietary supplementation with hybrid palm oil alters liver function in the common Marmoset
Authors: Spreafico Flavia , Sales Rafael Carvalho , Gil-Zamorano Judit , Medeiros Priscylla da Costa , Latasa Maria-Jesús , Lima Monique Ribeiro , de Souza Sergio Augusto Lopes , Martin-Hernández Roberto , Gómez-Coronado Diego , Iglesias-Gutierrez Eduardo , Mantilla-Escalante Diana C. , das Graças Tavares do Carmo Maria , Dávalos Alberto 
Published: February 2018

AbstractHybrid palm oil, which contains higher levels of oleic acid and lower saturated fatty acids in comparison with African palm oil, has been proposed to be somehow equivalent to extra virgin olive oil. However, the biological effects of its consumption are poorly described. Here we have explored the effects of its overconsumption on lipid metabolism in a non-human primate model, the common marmoset. Dietary supplementation of marmoset with hyperlipidic diet containing hybrid palm oil for 3 months did not modify plasma lipids levels, but increased glucose levels as compared to the supplementation with African palm oil. Liver volume was unexpectedly found to be more increased in marmosets consuming hybrid palm oil than in those consuming African palm oil. Hepatic total lipid content and circulating transaminases were dramatically increased in animals consuming hybrid palm oil, as well as an increased degree of fibrosis. Analysis of liver miRNAs showed a selective modulation of certain miRNAs by hybrid palm oil, some of which were predicted to target genes involved in cell adhesion molecules and peroxisomal pathways. Our data suggest that consumption of hybrid palm oil should be monitored carefully, as its overconsumption compared to that of African palm oil could involve important alterations to hepatic metabolism.
Verification of radiodynamic therapy by medical linear accelerator using a mouse melanoma tumor model
Authors: Takahashi Junko , Murakami Mami , Mori Takashi , Iwahashi Hitoshi 
Published: February 2018

AbstractCombined treatment with 5-aminolevulinic acid (5-ALA) and X-rays improves tumor suppression in vivo. This is because the accumulated protoporphyrin IX from 5-ALA enhances the generation of ROS by the X-ray irradiation. In the present study, a high-energy medical linear accelerator was used instead of a non-medical low energy X-ray irradiator, which had been previously used. Tumor-bearing mice implanted with B16-BL6 melanoma cells were treated with fractionated doses of irradiation (in total, 20 or 30 Gy), using two types of X-ray irradiator after 5-ALA administration. Suppression of tumor growth was enhanced with X-ray irradiation in combination with 5-ALA treatment compared with X-ray treatment alone, using both medical and non-medical X-ray irradiators. 5-ALA has been used clinically for photodynamic therapy. Thus, “radiodynamic therapy”, using radiation from medical linacs as a physical driving force, rather than the light used in photodynamic therapy, may have potential clinical applications.
Superoscillations in solar MHD waves and their possible role in heating coronal loops
Authors: López Ariste A. , Facchin M. 
Published: February 2018

Aims. We aim to study the presence of superoscillations in coronal magnetoacoustic (MHD) waves and their possible role in heating coronal loops through the strong and localised gradients that they generate on the wave.
Methods. An analytic model is built for the transition between sausage and kink wave modes propagating along field lines in the corona. We compute in this model the local frequencies, the wave gradients, and the associated heating rates due to compressive viscosity.
Results. We find superoscillations associated with the transition between wave modes accompanying the wave dislocation that shifts through the wave domain. Frequencies ten times higher than the normal frequency are found. This means that a typical three-minute coronal wave will oscillate locally in 10 to 20 s. Such high frequencies bring up strong gradients that efficiently dissipate the wave through compressive viscosity. We compute the associated heating rates; locally, they are very strong, largely compensating typical radiative losses.
Conclusions. We find a new heating mechanism associated to magnetoacoustic waves in the corona. Heating due to superoscillations only happens along particular field lines with small cross sections, comparable in size to coronal loops, inside the much larger magnetic flux tubes and wave propagation domain.
Komorbiditäten und Mortalität bei Patienten mit entzündlichen Gelenkerkrankungen
Authors: Kleinert Stefan 
Published: February 2018

ZusammenfassungDie entzündlichen Gelenkerkrankungen werden zunehmend als Systemerkrankungen angesehen. Systemische Manifestationen und Komorbiditäten wie kardiovaskuläres Risiko, Fatigue und Depression, Anämie, Osteoporose und erhöhte Mortalität sind in den letzten Jahren zunehmend in den klinischen und wissenschaftlichen Blickpunkt geraten. Infektionsrisiko, chronische Nieren- und Lungenerkrankungen können die Therapie im klinischen Alltag komplizieren. Einschränkungen der Kognition oder der sexuellen Funktion sind dagegen kaum wissenschaftlich erfasst und werden vermutlich auch auf Arzt-Patienten-Ebene unzureichend adressiert. Eine systematische Umsetzung der Erfassung und des Management von Komorbiditäten ist notwendig, um die Mortalität von Patienten mit entzündlichen Systemerkrankungen zu reduzieren und die Lebensqualität zu verbessern. Eine solche Umsetzung wird aber derzeit vom kassenärztlichen System nicht vergütet.
Erhöhtes Schlaganfallrisiko nach Neck Dissection?
Authors: Park Jonas J.-H. 
Published: February 2018

Cramer JD et al. Is Neck Dissection Associated with an Increased Risk of Postoperative Stroke? Otolaryngol Head
Neck Surg 2017; 157(2): 226–232
Der Schlaganfall gehört zu den schwersten Komplikationen der Kopf- und Hals- Chirurgie. Wie hoch das Risiko
speziell nach einer Neck Dissection ist, haben Cramer und Kolleginnen/Kollegen jetzt in einer
retrospektiven Kohortenstudie genauer untersucht.
Zeiterfassung in der Endoskopie
Authors: Schmitt Klaus , Schweizer Rebecca 
Published: February 2018

ZusammenfassungZeiterfassung in der Endoskopie wird immer wichtiger. Sie dient als Nachweis der geleisteten Arbeit, dokumentiert aber auch die geleistete Qualität. Hier sollten und müssen wir uns von der pflegerischen Seite einbringen und unseren nicht unwichtigen Anteil am Gelingen einer endoskopischen Intervention transparent machen. In Fragen der Personalbedarfsberechnung ist die Zeiterfassung unverzichtbar, um die individuelle Situation der eigenen Abteilung realistisch abbilden zu können. Die Hersteller von Dokumentationsprogrammen sollten ermutigt werden, in ihre Produkte Module zu integrieren, mit denen das Erfassen von Eckpunkten der pflegerischen und ärztlichen Tätigkeit individuell, leicht veränderbar, einfach, möglich ist. Dies würde der Zeiterfassung in der Endoskopie einen neuen „Schub“ bringen.
Medikamentöse Therapie des Schilddrüsenknotens
Authors: Derwahl Karl-Michael 
Published: February 2018

ZusammenfassungWährend in Regionen mit ausreichender Iodversorgung die Therapie des Schilddrüsenknotens mit Levothyroxin
weitgehend verlassen wurde und auch nicht mehr in den Leitlinien empfohlen wird, gibt es für eine
medikamentöse Therapie von Schilddrüsenknoten in Deutschland eine Indikation, wie die randomisierte,
placebokontrollierte LISA-Studie nachgewiesen hat.Wesentlicher Grund ist ein leichter Iodmangel bei Patienten mit Schilddrüsenknoten. In der LISA-Studie führte
eine Levothyroxin-Iodid-Kombinationstherapie zu einer mindestens 50 %igen Volumenreduktion der Knoten bei 21,6
% der Patienten gegenüber bei nur 5,2 % der Placebo-Behandelten.Unter der kombinierten L-T4-Iodidtherapie wird der TSH-Wert im unteren Referenzbereich eingestellt, eine
TSH-Suppression (latente Hyperthyreose) muss vermieden werden, da sie zu Herzrhythmusstörungen führen
kann.Im höheren Alter muss aufgrund der kardiovaskulären Risiken die Indikation zu einer Schilddrüsenhormontherapie
überprüft, die Dosis häufig reduziert oder die Therapie abgesetzt werden.
Administrative Prävalenz und Versorgungssituation der Demenz im Krankenhaus – Eine versorgungsepidemiologische Studie basierend auf GKV-Daten sächsischer Versicherter
Authors: Motzek Tom , Werblow Andreas , Schmitt Jochen , Marquardt Gesine 
Published: February 2018

Zusammenfassung
Ziel der Studie Menschen mit Demenz stellen das Versorgungsystem – und insbesondere die akutstationäre Versorgung – vor große Herausforderungen. Anhand von Routinedaten soll die kleinräumige administrative Prävalenz bzw. Diagnosehäufigkeit der Demenz, die administrative Prävalenz im Krankenhaus und die Versorgungssituation im Krankenhaus untersucht werden.
Methoden Es wurden Routinedaten der gesetzlichen Krankenversicherung AOK PLUS für Sachsen im Jahr 2014 ausgewertet. Eine Demenz lag vor, wenn in mind. 3 von 4 Quartalen eine ambulante oder stationäre Demenzdiagnose identifiziert werden konnte (n=61 700). Für die Analysen der Versorgungssituation im Krankenhaus wurden 61 239 Personen mit und 183 477 Kontrollpersonen ohne Demenz eingeschlossen. Die Auswahl der Kontrollgruppe erfolgte gematched nach Alter, Geschlecht und Wohnort im Verhältnis 1:3.
Ergebnisse Die administrative Ein-Jahres-Prävalenz bzw. Diagnosehäufigkeit der Demenz der über 65-Jährigen betrug 9,3%. Die Hochrechnung der administrativen Prävalenz der Demenz im Krankenhaus ergab für die über 65-jährigen Krankenhauspatienten eine Rate von 16,7%. Personen mit Demenz hatten um 33% mehr Krankenhauseinweisungen, eine um 36% längere Pro-Kopf Verweildauer und um 18% höhere akutstationäre Kosten je Personenjahr als Personen ohne Demenz. Die längere Verweildauer und höheren Kosten wurden überwiegend durch die höhere Einweisungshäufigkeit verursacht. Die akutstationären Inanspruchnahmen von Patienten mit Demenz waren – im Vergleich zu Patienten ohne Demenz – eher durch pflegerische und betreuende Bedarfe, als durch therapeutische und diagnostische Bedarfe charakterisiert.
Schlussfolgerungen Um die Versorgungslage der Menschen mit Demenz zu verbessern, den Herausforderungen für die Krankenhäuser zu begegnen und um die finanziellen Belastungen der sozialen Sicherungssysteme zu reduzieren, sind zukünftig Verbesserungen notwendig. Dies umfasst unteren anderen Verbesserungen in den Erkennungsraten der Demenz und die Reduktion von vermeidbaren Krankenhauseinweisungen.
Diamond anvil cell behavior up to 4 Mbar
Authors: Li Bing , Ji Cheng , Yang Wenge , Wang Junyue , Yang Ke , Xu Ruqing , Liu Wenjun , Cai Zhonghou , Chen Jiuhua , Mao Ho-kwang 
Published: February 2018

Significance
Diamond anvil cell (DAC) could be one of the most popular and versatile devices to generate static high pressure. By using beveled anvils, researchers can study materials up to 4 Mbar, which is considered as a limit pressure of conventional DAC; however, very few experiments have visited this pressure region. Here, we have systematically studied the behaviors of three DACs with three typical culet sizes, one of which reached 4 Mbar. In addition, by using submicrometer synchrotron X-ray probe, double cupping of beveled diamond anvils up to 4 Mbar is reported experimentally. Our results provide important guidance for future DAC studies to extreme high pressures.
The guise of the good and the problem of partiality
Authors: Hazlett Allan 
Published: February 2018

AbstractAccording to the guise of the good thesis, we desire things under the ‘guise of the good.’ Here I sympathetically articulate a generic formulation of the guise of the good thesis, and address a problem for the view, which I call the problem of partiality. The problem is, roughly, that our partial pro-attitudes–for example, our special concern for ourselves–do not correspond to what is absolutely good. I criticize three solutions to the problem, and propose an alternative strategy, on which partial pro-attitudes constitute a species of illusion.
Principal metabolic flux mode analysis
Authors: Bhadra Sahely , Blomberg Peter , Castillo Sandra , Rousu Juho 
Published: February 2018

Abstract

Motivation
In the analysis of metabolism, two distinct and complementary approaches are frequently used: Principal component analysis (PCA) and stoichiometric flux analysis. PCA is able to capture the main modes of variability in a set of experiments and does not make many prior assumptions about the data, but does not inherently take into account the flux mode structure of metabolism. Stoichiometric flux analysis methods, such as Flux Balance Analysis (FBA) and Elementary Mode Analysis, on the other hand, are able to capture the metabolic flux modes, however, they are primarily designed for the analysis of single samples at a time, and not best suited for exploratory analysis on a large sets of samples.

Results
We propose a new methodology for the analysis of metabolism, called Principal Metabolic Flux Mode Analysis (PMFA), which marries the PCA and stoichiometric flux analysis approaches in an elegant regularized optimization framework. In short, the method incorporates a variance maximization objective form PCA coupled with a stoichiometric regularizer, which penalizes projections that are far from any flux modes of the network. For interpretability, we also introduce a sparse variant of PMFA that favours flux modes that contain a small number of reactions. Our experiments demonstrate the versatility and capabilities of our methodology. The proposed method can be applied to genome-scale metabolic network in efficient way as PMFA does not enumerate elementary modes. In addition, the method is more robust on out-of-steady steady-state experimental data than competing flux mode analysis approaches.

Availability and implementation
Matlab software for PMFA and SPMFA and dataset used for experiments are available in https://github.com/aalto-ics-kepaco/PMFA.

Supplementary information
Supplementary data are available at Bioinformatics online.
L1000FWD: fireworks visualization of drug-induced transcriptomic signatures
Authors: Wang Zichen , Lachmann Alexander , Keenan Alexandra B , Ma’ayan Avi 
Published: February 2018

Abstract

Motivation
As part of the NIH Library of Integrated Network-based Cellular Signatures program, hundreds of thousands of transcriptomic signatures were generated with the L1000 technology, profiling the response of human cell lines to over 20 000 small molecule compounds. This effort is a promising approach toward revealing the mechanisms-of-action (MOA) for marketed drugs and other less studied potential therapeutic compounds.

Results
L1000 fireworks display (L1000FWD) is a web application that provides interactive visualization of over 16 000 drug and small-molecule induced gene expression signatures. L1000FWD enables coloring of signatures by different attributes such as cell type, time point, concentration, as well as drug attributes such as MOA and clinical phase. Signature similarity search is implemented to enable the search for mimicking or opposing signatures given as input of up and down gene sets. Each point on the L1000FWD interactive map is linked to a signature landing page, which provides multifaceted knowledge from various sources about the signature and the drug. Notably such information includes most frequent diagnoses, co-prescribed drugs and age distribution of prescriptions as extracted from the Mount Sinai Health System electronic medical records. Overall, L1000FWD serves as a platform for identifying functions for novel small molecules using unsupervised clustering, as well as for exploring drug MOA.

Availability and implementation
L1000FWD is freely accessible at: http://amp.pharm.mssm.edu/L1000FWD.

Supplementary information
Supplementary data are available at Bioinformatics online.
omicsPrint: detection of data linkage errors in multiple omics studies
Authors: van Iterson Maarten , Cats Davy , Hop Paul ,   BIOS Consortium, Heijmans Bastiaan T 
Published: February 2018

Abstract

Summary
OmicsPrint is a versatile method for the detection of data linkage errors in multiple omics studies encompassing genetic, transcriptome and/or methylome data. OmicsPrint evaluates data linkage within and between omics data types using genotype calls from SNP arrays, DNA- or RNA-sequencing data and includes an algorithm to infer genotypes from Illumina DNA methylation array data. The method uses classification to verify assumed relationships and detect any data linkage errors, e.g. arising from sample mix-ups and mislabeling. Graphical and text output is provided to inspect and resolve putative data linkage errors. If sufficient genotype calls are available, first degree family relations also are revealed which can be used to check parent–offspring relations or zygosity in twin studies.

Availability and implementation
omicsPrint is available from BioConductor; http://bioconductor.org/packages/omicsPrint.

Supplementary information
Supplementary data are available at Bioinformatics online.
Dietary Shifts at the Mesolithic–Neolithic Transition in Europe
Authors: Schulting Rick J. 
Published: February 2018

AbstractThe nature of the transition to agriculture has been widely debated, particularly in the context of north-western Europe, where stable carbon and nitrogen isotope data have been argued to indicate a rapid, sharp shift in diet. However, other lines of evidence sometimes suggest a less complete break. This chapter provides a broad overview of this debate, drawing on the large amount of isotope data now available that permits wider regional considerations of trends in coastal and inland contexts across Europe. A clear pattern emerges, with significant differences between Mesolithic and Neolithic isotopic composition, and, by inference, diets. There are a number of notable exceptions—at the individual, site, and regional levels. Some of these can be explained simply through terminology (i.e. ‘Neolithic’ being defined regionally through technology rather than subsistence), while others appear to relate to specific local environmental conditions placing foraging and farming on a more equal footing.
Queer Audiovisual Creativity
Authors: Treadwell Nina 
Published: February 2018

Abstract
This chapter introduces readers to the practice of creating fan music videos, commonly referred to as vids or fanvids. Fans combine preexisting material from films or television with music in order to refocus the original source material for various purposes, ranging from critique to celebration. This chapter focuses on vidding as queer practice; it provides an overview of vidding from the mid-1970s to the present and incorporates close readings of vids dedicated to Star Trek and the British drama series Bad Girls, originally broadcast on ITV from 1999 to 2006. The chapter argues for the importance of music as a central facet related to the meaning-making process of vids, a dimension that has been neglected in current scholarship on fannish vidding.
Zwitterionic molecule layer for inhibiting microbial corrosion of copper alloy
Authors: Xu Fengling , Qiu Zhenghui , Qiu Ri , Yang Jiadong , Lin Cunguo 
Published: February 2018

Purpose
For mitigating biocorrosion induced by sulfate-reducing bacteria (SRB) in seawater, the zwitterionic molecule layer (ZML) of poly (sulfobetaine methacrylate) is grafted onto B10 surface by chemical vapor deposition and surface-initiated atom transfer radical polymerization.

Design/methodology/approach
Energy-dispersive spectroscopy-attenuated total reflectance Fourier transform infrared spectroscopy and static contact angle measurements are used to characterize the as-formed layer.

Findings
After surface modification, B10 can significantly reduce SRB adhesion, demonstrating the good antifouling property. Further, the biocorrosion inhibition is investigated by potentiodynamic polarization and electrochemical impedance spectroscopy, indicating that ZML exhibits high resistance to biocorrosion with inhibition efficiency of approximately 90 per cent.

Originality/value
ZML performs a dual feature, i.e. antifouling film and corrosion inhibitor, for the biocorrosion inhibition.