bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mid-regional pro-atrial natriuretic peptide as a biomarker of left ventricular systolic dysfunction in patients with sepsis
Authors: Wasyanto Trisulo , Hermawan Guntur 
Published: August 2019

BACKGROUND Releasing cytokine pro inflammation in patients with sepsis (tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β) and IL-6) with other factors (mid regional pro atrial natriuretic peptide [MR-proANP] and TNF-α) will cause left ventricular systolic dysfunction (LVSD). This research aimed to prove MR-proANP as a biomarker of LVSD in sepsis, area under the curve (AUC), sensitivity, specificity, cut-off point and probability of MR-proANP and TNF-α as a biomarker of LVSD.
METHODS Non-experimental diagnostic test with cross sectional design and simple random sampling. Variable examined consisted of MR pro ANP, TNF-α and left ventricular ejection fraction (LVEF). LVSD if LVEF was ≤45%. Statistical analysis using 2 × 2 table and receiver operating characteristic curve using SPSS 22 for window.
RESULTS There were examined 71 patients from November 2013 to March 2014 in tertiary ICU of Moewardi Hospital. There were 22 patients with mild sepsis (30.9%), 40 patients with severe sepsis (56.4%) and 9 patients with septic shock (12.7%). The AUC value of MR-proANP level was 0.84 (95% CI 0.73–0.95), p < 0.001. Optimal cut off point was ≥225.95 pmol/l and diagnostic odd ratio (DOR) was 12.11. The AUC value of TNF-α level was 0.73 (95% CI 0.60–0.86), p < 0.002. Optimal cut-off point was ≥7.36 pg/ml and DOR was 5.03. Multivariate analysis was resulted that MR-proANP was the best predictor of LVSD (AUC 0.78), and TNF-α (0.69).
CONCLUSIONS MR-proANP could be used as a biomarker and the best diagnostic predictor of LVSD.
Effects of low glycemic index diet on insulin resistance among obese adolescent with non-alcoholic fatty liver disease: a randomized controlled trial
Authors: Utari Agustini , Maududi Muhammad Saifulhaq , Kusumawati Ninung Rose Diana , Mexitalia Maria 
Published: August 2019

BACKGROUND Obesity is strongly correlated with insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD). Some studies suggest that dietary intake with low glycemic index (GI) may prevent IR and reduce the incidences of NAFLD. This study was aimed to determine the effects of low GI diet on IR among obese adolescents with NAFLD.
METHODS This study was a randomized controlled trial conducted in two JuniorHigh Schools in Semarang, Indonesia. The subjects were 12–14 years obese students with NAFLD, which divided into intervention and control groups according to schools using block random allocation. The intervention group received nutrition education and lunch diet (low energy, low GI, and low fat); meanwhile, the control group only received nutrition education for 12 weeks. The biochemical evaluation included fasting blood glucose (FBG) and insulin levels. IR was assessed using homeostatic model assessment-insulin resistance (HOMA-IR).
RESULTS Thirty-two subjects were enrolled in this study, 16 of which were assigned to the intervention group and the other to the control group. After 12 weeks, the energy and carbohydrate intake reduced in the intervention group (p < 0.05), FBG remained unchanged, and HOMA-IR increased (4.9 [3.7]–7.2 [3.5]) compared to the control group (6.4 [4.9]–5.5 [2.8]) (p < 0.05). Meanwhile, within the control group, there were no significant differences in the energy and carbohydrate intake as well as biochemical variables.
CONCLUSIONS Low GI modification diet alone may not reduce IR in the obeseadolescents with NAFLD.
Decreased sensitivity of several anticancer drugs in TMEPAI knockout triple-negative breast cancer cells
Authors: Wardhani Bantari Wisynu Kusuma , Puteri Meidi Utami , Watanabe Yukihide , Louisa Melva , Setiabudy Rianto , Kato Mitsuyasu 
Published: August 2019

BACKGROUND Transmembrane prostate androgen-induced protein (TMEPAI) was reported to be highly amplified in the majority of patients with triple-negative breast cancer (TNBC). TMEPAI is related to poorer prognosis, limited treatment options, and prone to drug resistance compared with other proteins. One of the established markers to determine cancer resistance to drugs is the increased expression levels of drug efflux transporters. However, the role of TMEPAI in cancer resistance to drugs has not been elucidated. This study was aimed to investigate whether TMEPAI participates in cancer resistance to drugs by regulating drug efflux transporters.
METHODS TMEPAI knockout (KO) cells were previously developed from a TNBC cell line, Hs578T (wild-type/WT), using a CRISPR-Cas9 system. The expression levels of drug efflux transporters were determined in Hs578T-KO and Hs578-WT by quantitative reverse transcriptase polymerase chain reaction. Cytotoxic concentration 50% (CC50) of several anticancer drugs (doxorubicin, cisplatin, and paclitaxel) were determined in the two cell lines via 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay.
RESULTS The results showed that the mRNA expression of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) was significantly increased in Hs578T-KO compared with that in Hs578T-WT cells. CC50 of several anticancer drugs investigated (doxorubicin, paclitaxel, and cisplatin) in Hs578T-KO cells was higher than that in Hs678-WT.
CONCLUSIONS TMEPAI participated in the regulation of mRNA expression levels in drug efflux transporters (P-gp, BCRP, and multidrug resistance-associated protein 1). Further studies are necessary to confirm whether this finding might be dependent on the development of cancer cell sensitivity to anticancer agents.
Deradikalisasi Masjid Inklusi: Upaya Penghapusan Ideologi Radikal di Yogyakarta
Authors: Muryanti Muryanti , Mulyani Tri 
Published: August 2019

Radicalization has recently strengthened in Indonesia. The real act makes in burning and killing war. The violence war takes the results in casualties and damage. This paper talks the process of deradicalization in the cases of phenomenology radicalization in recent years. One of the activities on the issue is to restore the function of the mosque with various activities at 3 important mosques in Yogyakarta. The UIN Sunan Kalijaga Mosque as a Religious Laboratory in the development of da'wah, the Syuhada Mosque as an Educational and economic institution, and the Jogokaryan Mosque as a pesantren in prospering the environment. These 3 findings indicate the potential character of the inclusion mosque. This gave rise to empowerment activities in religious studies and economic education. the activities in the mosque's efforts to reduce radicalization based on religion.Radikalisasi atas nama agama akhir-akhir ini menguat di Indonesia. Wujud nyata dari hal tersebut adalah aksi teror. Hal ini menggunakan kekerasan yang berakibat korban jiwa dan kerusakan. Tulisan ini hendak mengkaji proses deradikalisasi dalam fenomena pada banyak kasus radikalisasi beberapa tahun ini. Salah satu aktivitas pada isu tersebut mengembalikan fungsi masjid dengan berbagai macam kegiatan pada 3 masjid penting di Yogyakarta. Masjid UIN Sunan Kalijaga sebagai Laboratorium Agama dalam pengembangan dakwah, Masjid Syuhada sebagai Lembaga Pendidikan dan ekonomi, dan Masjid Jogokaryan sebagai pesantren dalam memakmurkan lingkungan tersebut. 3 temuan ini menunjukan potensi karakter masjid inklusi. Hal ini memunculkan kegiatan pemberdayaan dalam kajian keagamaan dan Pendidikan ekonomi. Berbagai macam kegiatan dalam aktivitas masjid tersebut merupakan upaya meredam radikalisasi berbasiskan agama.
Niklas Luhmann’s theory of social system and the reflection on translation system
Authors: Mutlu Sıla 
Published: August 2019

This article aims at discussing an important problem of university education from the point of view of translation studies. The relation of translation education and the translation curriculum with social practice, and the counterpart of translation studies departments in the social system, constitute an important problem in the field of translation. It is possible to increase the quality of the translation industry through translation education by identifying the counterparts of translation education and translation theories in practice, and their positions within the translation system. The realisation of this objective is possible by considering translation as a system. Thanks to this approach of considering translation as a system, the positions of the actors within the translation system may be reinterpreted. This article aims at redefining the position of all stakeholders of the translation system within the translation system.
Extended English summary is in the end of Full Text PDF (TURKISH) file.

Özet
Bu makale üniversite eğitiminin en önemli sorunlarından birisi olan kuram pratik ilişkisini çeviribilim perspektifinden tartışmayı amaçlamaktadır. Kuram ve uygulama bir sistemin dönüşüm hallerini temsil ederler. Kuramdan pratiğe ve pratikten kurama dönüşle gerçekleşen toplumsal sistemler, kendi bağımsız işleyişlerini ve kalitelerini sürdürme yeteneğini geliştirebilirler. Çeviri eğitiminin ve çeviri müfredatının toplumsal pratikle ilişkisi ve çeviri bölümlerinin toplumsal sistemdeki karşılığı çeviri alanının önemli bir sorunsalıdır. Çeviri eğitimi ve çeviri kuramlarının pratikteki karşılıkları ve çeviri sistemi içindeki konumlarının yeniden belirlenerek, çeviri sektörünün çeviri eğitimi yoluyla kalitesini artırması mümkündür. Bu amacın gerçekleşebilmesi çevirinin bir sistem olarak ele alınmasıyla mümkündür. Çevirinin bir sistem olarak ele alınması sayesinde, çeviri sistemindeki aktörlerin konumları yeniden yorumlanabilir. Bu yazı, Luhmann’ın sistem kuramından yola çıkarak, çeviri sisteminin tüm paydaşlarının çeviri sistemindeki rolünün yeniden belirlenmesini amaçlamaktadır.
Serum level of insulin-like growth factor-I in type 2 diabetic patients: impact of obesity
Authors: Aleidi Shereen M. , Shayeb Eman , Bzour Jameel , Abu-rish Eman Y. , Hudaib Mohammad , Al Alawi Sundus , Bustanji Yasser 
Published: August 2019

Abstract

Background
Insulin-like growth factor-I (IGF-I) is homologous to proinsulin and possesses glucose reducing activity. The association between the level of IGF-I and diabetes has been highlighted. However, this association is controversial due to the influence of different factors including obesity. The aim of the study was to evaluate serum level of IGF-I in type 2 diabetic patients compared to control subjects.

Materials and methods
A cross-sectional study involving 100 participants was conducted. Serum levels of IGF-I were measured using enzyme-linked immunosorbent assay (ELISA) and the fasting plasma glucose (FPG) levels were measured using the glucose oxidase method.

Results
IGF-I levels in the diabetic patients were significantly lower than in non-diabetic control subjects (105.13 ± 6.34 vs. 159.96 ± 9.62 ng/mL, p < 0.0001). Among the diabetic group, there was no significant difference in IGF-I levels between obese diabetic patients and non-obese diabetic patients, p = 0.18. Similarly, among the non-diabetic group, a non-significant difference was found in IGF-I levels between obese non-diabetic and non-obese non-diabetic subjects, p = 0.156. However, among the obese group, obese diabetic patients had significantly lower IGF-I serum levels compared to obese non-diabetic subjects (112.07 ± 7.97 vs. 147.07 ± 13.05 ng/mL, p = 0.02). Furthermore, among the non-obese group, the non-obese diabetic patients had significantly lower IGF-I serum levels compared to the non-obese non-diabetic subjects (91.66 ± 9.93 vs. 171.86 ± 13.86 ng/mL, p < 0.0001). No significant associations were observed between IGF-I level and any of the age, gender, body mass index (BMI), FPG levels, or the duration of diabetes.

Conclusions
Type 2 diabetes mellitus is associated with lower levels of IGF-I regardless to the presence or absence of obesity.
Russland und Deutschland im Schicksal und Schaffen des Schriftstellers Eugen Gagarin
Authors: Galimova Elena Š. , Polikarpov Aleksandr M. , Korin Sabine 
Published: August 2019

Summary
Little is known about the life and literary creations of Eugen Gagarin. This article deals with the facts known so far and explores archive material to expand and partially correct them. The writer Evgenij Andreevich Gagarin (1905‒1948) was born in the province of Arkhangelʼsk (Archangelʼskaja gubernija) and emigrated to Germany in 1933, where he started writing. Until his tragic accidental death in 1948 he wrote various oeuvres in German and in Russian, including the 1948 novel Vozvraščenie Korneta (‘The Return of the Cornet’), which bears autobiographical features. First published in Russia in 1991, it initiated the acquisition of his works in Russia. This article seeks to contributes to the academic analysis of Gagarin’s Œuvre by systematizing and completing the biographical data on Eugen Gagarin and his family, as well as the information on the publications of Gagarinʼs works.
Brain gene expression in a novel mouse model of postpartum mood disorder
Authors: Humby Trevor , Davies William 
Published: August 2019

Abstract

Background
Steroid sulfatase (STS) cleaves sulfate groups from steroid hormones; its expression/activity increases in late pregnancy and into the postpartum period. STS-deficient human and mouse mothers display elevated psychopathology and abnormal behaviour respectively; in mice, these effects can be partially normalised by antipsychotic (ziprasidone) administration.

Methodology
We compared brain gene expression in new mouse mothers administered the STS inhibitor 667-Coumate, or vehicle; significant changes were followed-up with pathway analysis and quantitative polymerase chain reaction (qPCR). Finally, the effects of combined 667-Coumate and ziprasidone administration on expression of the most robustly differentially-expressed genes were examined.

Results
Surprisingly, no between-group gene expression changes were detected at a False Discovery Rate (FDR)-corrected p<0.1. 1,081 unique expression changes were detected at p<0.05, two top hits were verified by qPCR, and pathway analysis indicated enrichment of genes involved in olfactory transduction. The expression of Stoml3 and Cyp2g1 was unaffected by ziprasidone administration.

Conclusions
Postpartum behavioural abnormalities in STS-deficient mothers are likely to be the culmination of many small gene expression changes. Our data are consistent with the idea that olfactory function is key to maternal behaviour in mice, and suggest that aberrant expression of olfactory system genes may underlie abnormal maternal behaviour in STS-deficient women.
Dynamic Gain Analysis Reveals Encoding Deficiencies in Cortical Neurons That Recover from Hypoxia-Induced Spreading Depolarizations
Authors: Revah Omer , Stoler Ohad , Neef Andreas , Wolf Fred , Fleidervish Ilya A. , Gutnick Michael J. 
Published: August 2019

Cortical regions that are damaged by insults, such as ischemia, hypoxia, and trauma, frequently generate spreading depolarization (SD). At the neuronal level, SDs entail complete breakdown of ionic gradients, persisting for seconds to minutes. It is unclear whether these transient events have a more lasting influence on neuronal function. Here, we describe electrophysiological changes in cortical neurons after recovery from hypoxia-induced SD. When examined with standard measures of neuronal excitability several hours after recovery from SD, layer 5 pyramidal neurons in brain slices from mice of either sex appear surprisingly normal. However, we here introduce an additional parameter, dynamic gain, which characterizes the bandwidth of action potential encoding by a neuron, and thereby reflects its potential efficiency in a multineuronal circuit. We find that the ability of neurons that recover from SD to track high-frequency inputs is markedly curtailed; exposure to hypoxia did not have this effect when SD was prevented pharmacologically. Staining for Ankyrin G revealed at least a fourfold decrease in the number of intact axon initial segments in post-SD slices. Since this effect, along with the effect on encoding, was blocked by an inhibitor of the Ca2+-dependent enzyme, calpain, we conclude that both effects were mediated by the SD-induced rise in intracellular Ca2+. Although effects of calpain activation were detected in the axon initial segment, changes in soma-dendritic compartments may also be involved. Whatever the precise molecular mechanism, our findings indicate that in the context of cortical circuit function, effectiveness of neurons that survive SD may be limited.SIGNIFICANCE STATEMENTSpreading depolarization, which commonly accompanies cortical injury, entails transient massive breakdown of neuronal ionic gradients. The function of cortical neurons that recover from hypoxia-induced spreading depolarization is not obviously abnormal when tested for usual measures of neuronal excitability. However, we now demonstrate that they have a reduced bandwidth, reflecting a significant impairment of their ability to precisely encode high-frequency components of their synaptic input in output spike trains. Thus, neurons that recover from spreading depolarizations are less able to function normally as elements in the multineuronal cortical circuitry. These changes are correlated with activation of the calcium-dependent enzyme, calpain.
The Political Factors that affect Contemporary Art in the Arab world, Descriptive Analytical Study
Authors: Salameh Mohammad Ahmad. Bani , Rafee Yakup Mohd. , Al Smadi Tamara Adnan. 
Published: August 2019

This paper examining the determine the political factors that affect contemporary art in the Arab world. through what the Arabic artworks (study sample) contained ideas, there was internal and external political factors that affect contemporary Arabic art. the researcher will extract these factors by evaluating the findings made in respect to the political factors (internal and external) that influence the selected artworks (sample study). This step also includes the drawn conclusions in respect to the political factors (internal and external) that cause these political situations in the Arab world. The study sample contained seven Arabic contemporary installation artworks from 2010-2015 to determine the political factors that affect contemporary art in the Arab world. The findings were list combines the external and internal political factors that influence contemporary Arabic art in general because these factors include all the political factors and its comprehensive and appeared in contemporary Arabic artworks.
The Framing of a Problem through Gaming (Mathematics-STEM) Subject Content Areas
Authors: Ph.D. Charletta H. Barringer-Brown, 
Published: August 2019

According to Demeter (2015) over the past fourty years, scientists, engineers, philosophers, and psychologists have been concerned with the infinite number of social, economic, and physical issues that exist and that cannot be dealt with in isolation. As agruged by Wong, Luo, and Fong (2019) it has been found through experiments and piloting techniques that the existing traditional methods and knowledge is not suited into coping and addressing the unique and sophisticated situations. In the process of searching and coming up with techniques such the use of Bernoulli’s principle for aerodynamics and aviation, perturbation techniques, and the nonlinear approximation methods, it was discovered that physics, chemistry, and mathematics brings out a limited area of interest and therefore can only offer solutions to problems in narrow perspectives. For example, the aforementioned disciplines majorly concentrated on a particular subject of interest and use limited principles towards solving the identified problem, that is to say, a significant number of assumptions are brought into play in order to help in arriving at the intended destinations. Notably, the techniques applied in solving scientific problems do not regard competing frameworks and this contributed to their limited nature in solving social and physical problems. As suggested by Leaver,Willson, and Torres (2016) it is against this backdrop that, framing of a problem through gaming techniques in subject content areas is being encouraged since it involves competing frameworks and consequently works to reduce the number of assumptions plunged in the process of solving mathematical problem. Gaming techniques entails the combination of various techniques that can deal with adversities, uncertainty, unique, and sophisticated situations in the field of science. Fundamentally, framing of a problem through gaming tricks provides an advantage of combining the social-human with economic, technological, and physical domains. The outcome associated with the gaming technique is scientific improvements and increased applications of the available knowledge and information (Wong, Luo, and Fong, 2019).
Use of magnetoinfrared laser therapy in severe pediatric bronchial asthma
Authors: Illek Ya. Yu. , Mischenko I. Yu. , Ryseva L. L. , Vyaznikova M. L. , Tarasova E. Yu. , Leushina N. P. , Mamedova S. M. , Suetina I. G. , Khlebnikova N. V. , Solovyova G. V. 
Published: August 2019

Aim. To determine the influence of magnetoinfrared laser therapy on the clinicolaboratory indices in children with severe course of bronchial asthma.
Material and methods. There were observed 82 children aged 5–14 years, who suffered from severe course of atopic bronchial asthma.Bronchial asthma patients of group 1 (41 patients) received a complex standard therapy, bronchial asthma patients of group 2 – a complex treatment, combined with magnetoinfrared laser therapy courses.
Results. Patients with bronchial asthma, attributed to group 2, compared with those of group1 demonstrated a faster positive dynamics of clinical indices, improvement of respiratory function and normalization of most immunologic reactivity parameters, diminished severity of disease course and prolonged clinical remission.
Conclusions. High efficiency of magnetoinfrared laser therapy, safety and availability, absence of complications and side reactions permit to recommend its wide use in complex of medical measures for children with severe course of atopic bronchial asthma.
Organizational and educational program on formation and development of family medical activity
Authors: Dymova Irina A. , Karoyan Alvard A. 
Published: August 2019

Aim. To work out the organizational and educational program on formation and development of medical activity of a family and detect the key factors, determining and prognosticating its level.
Materials and methods.The method of questioning was used to study the medicosocial characteristic of living conditions and education in children of the first year of life, the mechanism of formation and development of medical activity in 244 families. On the basis of the data obtained, there was developed the organizational and educational program, directed to improvement of children’s health through the activity of district pediatrician; 214 women agreed to participate in the experiment.
Results. The paper is devoted to the necessity of improving the level of knowledge in parents of early age children. The growing sickness rate indices among the child population demonstrate the actuality of searching for methods to improve children’s health, in particular, by means of developing family medical activity.There were revealed and presented the factors, determining and forecasting the level of medical activity of a family, which plans to have a child.
Conclusions. To work out educational program on formation of medical activity, it is necessary to consider territorial characteristics of health status indices among child population and results of medicosocial diagnostics of families. Pediatrician, taking into account prognostic factors, can reveal “risk group” mothers and have individual approach to their training and practical formation and development of medical activity.