bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limits of regulatory responsiveness:Democratic credentials of responsive regulation
Authors: Hong Seung‐Hun , You Jong‐sung 
Published: March 2018

AbstractResponsiveness and accountability constitute the process of democratic representation, reinforcing each other. Responsiveness asks elected representatives to adopt policiesex antepreferred by citizens, while accountability consists of the people'sex postsanctioning of the representatives based on policy outcomes. However, the regulatory literature tends to interpret responsiveness narrowly between a regulator and regulatees: the regulator is responsive to regulatees’ compliance without considering broader public needs and preferences. Democratic regulatory responsiveness requires that the regulator should be responsive to the people, not just regulatees. We address this theoretical gap by pointing out the perils of regulatory capture and advancing John Braithwaite's idea of tripartism as a remedy. We draw out two conditions of democratic regulatory responsiveness from Philip Selznick – comprehensiveness and proactiveness. We then propose overlapping networked responsiveness based on indirect reciprocity among various stakeholders. This mechanism is the key to connecting regulatory responsiveness with accountability.
Online Information Sharing About Risks: The Case of Organic Food
Authors: Hilverda Femke , Kuttschreuter Margôt 
Published: March 2018

AbstractIndividuals have to make sense of an abundance of information to decide whether or not to purchase certain food products. One of the means to sense‐making is information sharing. This article reports on a quantitative study examining online information sharing behavior regarding the risks of organic food products. An online survey among 535 respondents was conducted in the Netherlands to examine the determinants of information sharing behavior, and their relationships. Structural equation modeling was applied to test both the measurement model and the structural model. Results showed that the intention to share information online about the risks of organic food was low. Conversations and email were the preferred channels to share information; of the social media Facebook stood out. The developed model was found to provide an adequate description of the data. It explained 41% of the variance in information sharing. Injunctive norms and outcome expectancies were most important in predicting online information sharing, followed by information‐related determinants. Risk‐perception‐related determinants showed a significant, but weak, positive relationship with online information sharing. Implications for authorities communicating on risks associated with food are addressed.
Deglacial record of palaeoearthquakes interpreted from mass transport deposits at three lakes near Rouyn‐Noranda, north‐western Quebec, Canada
Authors: Brooks Gregory R. 
Published: March 2018

AbstractAs part of an investigation of deglacial palaeoseismology within an intracratonic region of north‐eastern North America, the compilation of sub‐bottom acoustic profile surveys from study areas at Duparquet and Dufresnoy lakes, north‐western Quebec, Canada, produced thirteen and eight event horizon maps, respectively, depicting subaqueous mass transport deposits that are interbedded within Lake Ojibway glaciolacustrine varve deposits. Analysis of rhythmic couplets recovered in cores from both locations yielded varve ages with annual resolution for the event horizons relative to the regional Timiskaming varve series. These results are integrated with the published event horizon stratigraphy and varve chronology from nearby Lac Dasserat. The combined event horizon records for the three lakes overlap between varve years 1175 to 1625 (9395 to 8945 ± 200 cal year bp) and consist of 26 event horizons. Fifteen event horizons are inferred to be evidence of 11 palaeoearthquakes at qualitative levels of interpretative confidence varying from high to low. The palaeoearthquake interpretations and assessments of interpretative confidence are made from weightings of the event horizon signatures and, where possible, evidence supporting a stratigraphic footprint extending beyond a given study area. Occurring over a 450 varve year period when rapid crustal uplift was still underway, 11 interpreted palaeoearthquakes happened at an average rate of every ca 40 years. Relative to a published minimum threshold magnitude for generating a recognizable geomorphic signature, this average rate of occurrence exceeds the modern return period by two orders of magnitude. The palaeoearthquakes probably occurred within a period of elevated seismicity associated with rapid crustal unloading during deglaciation.
Type 1 innate lymphoid cell aggravation of atherosclerosis is mediated through TLR4
Authors: Wu C. , He S. , Liu J. , Wang B. , Lin J. , Duan Y. , Gao X. , Li D. 
Published: March 2018

AbstractILC populations elaborate a similar cytokine expression pattern with helper T cell subsets Th1, Th2 and Th17. Recent studies indicate that CD25+ILC2 could alleviate atherosclerosis by altering lipid metabolism, whereas the depletion of CD90‐expressing ILCs had no influence on atherosclerosis. Thus, these findings raise the question of whether ILC1 cells react on atherosclerosis. Hence, our group attempted to explore the role of ILC1 cells in atherosclerosis. We found that ILC1 cells have a high Th1‐like gene expression of T‐bet and IFN‐γ, which is distinct from ILC2, ILC3 or conventional NK (cNK) cells. Moreover, atherosclerotic lesions were greatly reduced in ApoE−/−Rag1−/− mice treated with anti‐NK1.1 mAbs for depleting ILC1 cells (ILC1+cNK cells), compared to ApoE−/−Rag1−/− mice treated with anti‐IL‐15R mAbs for depleting cNK cells, and these effects could be fully rescued through the adoptive transfer of ILC1 cells sorted from the spleen of ApoE−/−TLR4+/+ mice into ApoE−/−Rag1−/− mice treated with anti‐NK1.1 mAbs. However, the adoptive transfer of ILC1 cells sorted from the spleen of ApoE−/−TLR4−/− mice into ApoE−/−Rag1−/− mice treated with anti‐NK1.1 mAbs blocked the progression of atherosclerosis, indicating that the pro‐atherosclerotic role of ILC1 cells is dependent on TLR4. Furthermore, oxLDL‐induced increase in IFN‐γ expression from ApoE−/− ILC1 cells was correlated with the decrease in BACH2 expression. Taken together, ILC1 cells exist in atherosclerosis and aggravate atherosclerosis via increasing pro‐inflammatory cytokine expression in a TLR4/BACH2‐dependent manner.
Late Merge and Phases for Anti‐C‐Command Requirements
Authors: Abe Jun 
Published: March 2018

AbstractIn this article, I propose a unified explanation for the argument–adjunct asymmetries that have been observed regarding two seemingly unrelated anti‐c‐command requirements: (i) condition C and (ii) the anti‐c‐command requirement on argument ellipsis, observed in Abefor null arguments in Japanese. I argue that these asymmetries are best explained by the mechanism of late merge of adjuncts proposed by Lebeaux () with a derivational definition of c‐command à la Epstein (). Furthermore, I argue that the timing of late merge of adjuncts is regulated by phase theory in the way that adjuncts may be merged no later than completion of relevant operations at the phase domains they belong to.
Prospective monitoring of adenovirus infection and type analysis after allogeneic hematopoietic cell transplantation: A single‐center study in Korea
Authors: Kang Ji‐Man , Park Ki‐Sup , Kim Jong Min , Huh Hee Jae , Ki Chang‐Seok , Lee Nam Yong , Yoo Keon Hee , Sung Ki Woong , Koo Hong‐Hoe , Kim Yae‐Jean 
Published: March 2018

AbstractBackgroundEpidemiologic studies of human adenovirus (HAdV) in allogeneic hematopoietic cell transplantation (HCT) recipients have been conducted mostly in European countries where HAdV 2 (species C) has been most prevalent in the community. The main objective of this study was to investigate the epidemiology and the characteristics of HAdV infection in Korean allogeneic HCT recipients (<19 years).MethodsIn a prospective study from April 2012 to September 2015, HAdV in blood, urine, and stool specimens were monitored weekly from transplantation to day 100 or after if clinically suspected. HAdV infection was defined as positive HAdV PCR result in any specimens regardless of symptoms.ResultsA total of 1734 specimens were collected from 57 consecutively enrolled recipients. The cumulative incidence of HAdV infection at day 100, and 1 year was 10%, and 20%, and the incidence of viremia was 2% and 6%, respectively. The median onset time from HCT to viremia was 221 days (range, 7‐596 days). All viremia cases were caused by only HAdV 3 (species B), whereas several types were detected in stool. Among patients with HAdV infection, lower absolute lymphocyte counts and extensive chronic graft‐vs‐host disease were associated with viremia (P = .028 and P = .006, respectively).ConclusionsCompared to western studies, this study demonstrated a lower incidence and delayed onset of HAdV infections and HAdV 3 was most prevalent in Korea.
Voriconazole concentration is inversely correlated with corticosteroid usage in immunocompromised patients
Authors: Imataki Osamu , Yamaguchi Kazunori , Uemura Makiko , Fukuoka Noriyasu 
Published: March 2018

AbstractBackgroundVoriconazole (VRCZ) is a broad‐spectrum antifungal agent that can be administered both orally and intravenously. A high level of intra‐ and interindividual variability in serum drug therapeutic concentrations has been reported. We analyzed the influence of corticosteroid use on serum VRCZ concentration by assessing the correlation between corticosteroid dose and VRCZ trough level.MethodsImmunocompromised patients treated with VRCZ with or without corticosteroid use from June 2010 to March 2017 (6 years and 8 months) were reviewed in our institute. VRCZ and the corticosteroids were administered orally or intravenously. Corticosteroid treatment was considered as “concurrent” only if it was administered within 3 days before or after the initiation of VRCZ. All corticosteroids were converted to a prednisolone‐based dosage according to their anti‐inflammatory effect (relative glucocorticoid activity). VRCZ concentration was measured at the trough point on the day of steady state.ResultsA total of 85 samples were obtained from 38 patients. The medical records of 23 women and 15 men, with a median age of 61 years (range: 35‐86), were reviewed. Twenty‐one patients (55.3%, 21/38) received chemotherapy, and 28 (73.7%, 28/38) received corticosteroid therapy. The average and median daily doses of corticosteroids were 59.2 and 89.8 mg, respectively (range: 0.714‐377). VRCZ concentration was inversely correlated with corticosteroid dose (r = −.26). The VRCZ concentration was significantly decreased in the corticosteroid user compared to nonuser (P = .013). We evaluated the association of VRCZ concentration and corticosteroid dose in 3 patients among our cohorts for whom more than 5 points of data were available. Intraindividual analysis revealed the trough level of VRCZ concentration decreased as the corticosteroid dose increased. The patients’ underlying diseases were hematological diseases (n = 25) and immunological diseases (n = 13). Among accrual patients, no patients were undergoing stem cell transplantation, and no patients were treated with known confounders such as calcineurin inhibitors or phenytoin.ConclusionsVRCZ might be metabolized by an enzyme induced by corticosteroid treatment; therefore, intraindividual variation in VRCZ metabolism should be considered prior to concurrent treatment, especially for patients with hematological malignancies treated with corticosteroids.
Confirmed microsporidial graft infection in a HIV‐negative renal transplant recipient: A case report and review of the literature
Authors: Brown M. , Longano A. , Dendle C. , Polkinghorne K.R. , Kanellis J. 
Published: March 2018

AbstractMicrosporidia are intracellular organisms most commonly known to cause opportunistic infection in patients with human immunodeficiency virus (HIV). There have been several case reports of infection in solid organ and bone marrow transplant recipients. Here, we report a case of a non‐HIV–infected renal transplant patient with microsporidiosis of the renal tract associated with acute graft dysfunction. We also review the literature of 12 previously reported cases of microsporidiosis in patients with renal transplants who had described graft involvement. We review the pattern of illness as well as the common renal biopsy features when microsporidial infection is associated with renal graft infection.
Paradoxical immune reconstitution inflammatory syndrome associated with disseminated tuberculosis infection in an unrelated donor cord blood transplant recipient
Authors: Lee Yeon Joo , Bacchus Melissa , Schmidt Elizabeth , Chawla Mohit , Barker Juliet N. , Papanicolaou Genovefa A. 
Published: March 2018

AbstractTuberculosis (TB) is an infrequent infection after hematopoietic cell transplant (HCT), with associated mortality up to 30%. The utility of universal screening for latent TB in HCT candidates is controversial due to the lack of sensitive screening tests. We describe a case of disseminated TB infection complicated by immune reconstitution inflammatory syndrome in an adult double unit umbilical cord blood transplant recipient who originated from the United Arab Emirates.
Shoot phytochrome B modulates reactive oxygen species homeostasis in roots via abscisic acid signaling in Arabidopsis
Authors: Ha Jun‐Ho , Kim Ju‐Heon , Kim Sang‐Gyu , Sim Hee‐Jung , Lee Gisuk , Halitschke Rayko , Baldwin Ian T. , Kim Jeong‐Il , Park Chung‐Mo 
Published: March 2018

SummaryUnderground roots normally reside in darkness. However, they are often exposed to ambient light that penetrates through cracks in the soil layers which can occur due to wind, heavy rain or temperature extremes. In response to light exposure, roots produce reactive oxygen species (ROS) which promote root growth. It is known that ROS‐induced growth promotion facilitates rapid escape of the roots from non‐natural light. Meanwhile, long‐term exposure of the roots to light elicits a ROS burst, which causes oxidative damage to cellular components, necessitating that cellular levels of ROS should be tightly regulated in the roots. Here we demonstrate that the red/far‐red light photoreceptor phytochrome B (phyB) stimulates the biosynthesis of abscisic acid (ABA) in the shoots, and notably the shoot‐derived ABA signals induce a peroxidase‐mediated ROS detoxification reaction in the roots. Accordingly, while ROS accumulate in the roots of the phyb mutant that exhibits reduced primary root growth in the light, such an accumulation of ROS did not occur in the dark‐grown phyb roots that exhibited normal growth. These observations indicate that mobile shoot‐to‐root ABA signaling links shoot phyB‐mediated light perception with root ROS homeostasis to help roots adapt to unfavorable light exposure. We propose that ABA‐mediated shoot‐to‐root phyB signaling contributes to the synchronization of shoot and root growth for optimal propagation and performance in plants.
Are methodological quality and completeness of reporting associated with citation-based measures of publication impact? A secondary analysis of a systematic review of dementia biomarker studies
Authors: Mackinnon Shona , Drozdowska Bogna A , Hamilton Michael , Noel-Storr Anna H , McShane Rupert , Quinn Terry 
Published: March 2018

ObjectiveTo determine whether methodological and reporting quality are associated with surrogate measures of publication impact in the field of dementia biomarker studies.MethodsWe assessed dementia biomarker studies included in a previous systematic review in terms of methodological and reporting quality using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) and Standards for Reporting of Diagnostic Accuracy (STARD), respectively. We extracted additional study and journal-related data from each publication to account for factors shown to be associated with impact in previous research. We explored associations between potential determinants and measures of publication impact in univariable and stepwise multivariable linear regression analyses.Outcome measuresWe aimed to collect data on four measures of publication impact: two traditional measures—average number of citations per year and 5-year impact factor of the publishing journal and two alternative measures—the Altmetric Attention Score and counts of electronic downloads.ResultsThe systematic review included 142 studies. Due to limited data, Altmetric Attention Scores and electronic downloads were excluded from the analysis, leaving traditional metrics as the only analysed outcome measures. We found no relationship between QUADAS and traditional metrics. Citation rates were independently associated with 5-year journal impact factor (β=0.42; p<0.001), journal subject area (β=0.39; p<0.001), number of years since publication (β=-0.29; p<0.001) and STARD (β=0.13; p<0.05). Independent determinants of 5-year journal impact factor were citation rates (β=0.45; p<0.001), statement on conflict of interest (β=0.22; p<0.01) and baseline sample size (β=0.15; p<0.05).ConclusionsCitation rates and 5-year journal impact factor appear to measure different dimensions of impact. Citation rates were weakly associated with completeness of reporting, while neither traditional metric was related to methodological rigour. Our results suggest that high publication usage and journal outlet is not a guarantee of quality and readers should critically appraise all papers regardless of presumed impact.
Perceptions of rounding checklists in the intensive care unit: a qualitative study
Authors: Hallam Bethany Danae , Kuza Courtney C , Rak Kimberly , Fleck Jessica C , Heuston Melanie M , Saha Debjit , Kahn Jeremy M 
Published: March 2018

BackgroundRounding checklists are an increasingly common quality improvement tool in the intensive care unit (ICU). However, effectiveness studies have shown conflicting results. We sought to understand ICU providers’ perceptions of checklists, as well as barriers and facilitators to effective utilisation of checklists during daily rounds.ObjectivesTo understand how ICU providers perceive rounding checklists and develop a framework for more effective rounding checklist implementation.MethodsWe performed a qualitative study in 32 ICUs within 14 hospitals in a large integrated health system in the USA. We used two complementary data collection methods: direct observation of daily rounds and semistructured interviews with ICU clinicians. Observations and interviews were thematically coded and primary themes were identified using a combined inductive and deductive approach.ResultsWe conducted 89 interviews and performed 114 hours of observation. Among study ICUs, 12 used checklists and 20 did not. Participants described the purpose of rounding checklists as a daily reminder for evidence-based practices, a tool for increasing shared understanding of patient care across care providers and a way to increase the efficiency of rounds. Checklists were perceived as not helpful when viewed as overstandardising care and when they are not relevant to a particular ICU’s needs. Strategies to improve checklist implementation include attention to the brevity and relevance of the checklist to the particular ICU, consistent use over time, and integration with daily work flow.ConclusionOur results provide potential insights about why ICU rounding checklists frequently fail to improve outcomes and offer a framework for effective checklist implementation through greater feedback and accountability.
Systemic inflammation and suicide risk: cohort study of 419 527 Korean men and women
Authors: Batty G David , Jung Keum Ji , Lee Sunmi , Back Joung Hwan , Jee Sun Ha 
Published: March 2018

BackgroundData from only one study have been used to examine the relationship between systemic inflammation and later suicide risk, and a strong positive association was apparent. More research is needed, particularly looking at gender, not least because women are seemingly more vulnerable to inflammation-induced mood changes than men.MethodsThe Korean Cancer Prevention Study had a cohort of over 1 million individuals aged 30–95 years at baseline examination between 1992 and 1995, when white blood cell count, our marker of systemic inflammation, was assessed.ResultsA mean of 16.6 years of mortality surveillance gave rise to 1010 deaths from suicide in 106 643 men, and 1019 deaths from suicide in 312 884 women. There was little evidence of an association between our inflammation marker and suicide mortality in men after multiple adjustments. In women, however, those in the second inflammation quartile and higher experienced around 30% increase risk of death (HR 1.35; 95% CI: 1.11–1.64).ConclusionsHigher levels of systemic inflammation were moderately related to an elevated risk of suicide death in women but not in men.
The Stereotactic Intracerebral Hemorrhage Underwater Blood Aspiration (SCUBA) technique for minimally invasive endoscopic intracerebral hemorrhage evacuation
Authors: Kellner Christopher Paul , Chartrain Alexander G , Nistal Dominic A , Scaggiante Jacopo , Hom Danny , Ghatan Saadi , Bederson Joshua B , Mocco J 
Published: March 2018

BackgroundEndoscopic intracerebral hemorrhage (ICH) evacuation techniques have gained interest as a potential therapeutic option. However, the instrumentation and techniques employed are still being refined to optimize hemostasis and evacuation efficiency.ObjectiveWe describe the application of a specific endoscopic technique in the treatment of ICH called the Stereotactic Intracerebral Hemorrhage Underwater Blood Aspiration (SCUBA) technique. It differs from previously described minimally invasive ICH interventions in that it combines two separate neuroendoscopic strategies in two phases, the first under dry-field conditions and the second using a wet-field strategy.MethodsAll patients who underwent endoscopic ICH evacuation with the SCUBA technique from December 2015 to September 2017 were included.ResultsThe SCUBA technique was performed in 47 patients. The average evacuation percentage was 88.2% (SD 20.8). Active bleeding identified to derive from a specific source was observed in 23 (48.9%) cases. Active bleeding was addressed with irrigation alone in five cases (10.6%) and required electrocautery in 18 cases (38.3%). Intraoperative bleeding occurred in 3 patients (6.4%) and postoperative bleeding occurred in a single case (2.1%).ConclusionsThe SCUBA technique provides surgeons with a defined strategy for true endoscopic hematoma evacuation. In particular, the fluid-filled cavity in SCUBA Phase 2 has the potential to provide several advantages over the traditional air-filled strategy, including clear identification and cauterization of bleeding vessels and visualization of residual clot burden. Further investigation is necessary to compare this technique to others that are currently used.