bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Contribution of Ototoxic Medications to Hearing Loss Among Older Adults
Authors: Joo Yoonmee , Cruickshanks Karen J , Klein Barbara E K , Klein Ronald , Hong OiSaeng , Wallhagen Margaret I 
Published: July 2019

AbstractBackgroundOtotoxicity may interact with the effects of aging, leading to a more severe hearing loss than that associated with age alone. The purpose of this study was to explore the associations between ototoxic medication use and the incidence and progression of hearing loss in older adults with a population-based longitudinal study.MethodsEpidemiology of Hearing Loss Study participants (n = 3,753) were examined. Medication use was assessed using a standardized questionnaire by the examiners at each examination every 5 year. The ototoxic medications include loop diuretics, nonsteroidal anti-inflammatory drugs, antibiotics, chemotherapeutic agents, quinine, and acetaminophen in this study. Generalized estimating equations model was used as a proportional hazard discrete time analysis.ResultsNumber of ototoxic medications was associated with the risk of developing hearing loss during the 10-year follow-up period (hazard ratio [HR] = 1.15, 95% confidence interval [CI] = 1.06, 1.25) after adjusting for age, sex, smoking, and body mass index. Loop diuretics (HR = 1.40, 95% CI = 1.05, 1.87) were associated with the 10-year incidence of hearing loss. Nonsteroidal anti-inflammatory drugs (HR = 1.45, 95% CI = 1.22, 1.72) and loop diuretics (HR = 1.33 95% CI = 1.08, 1.63) were associated with risk of progressive hearing loss over 10 years.ConclusionThese ototoxic medications are commonly used in older adults and should be considered as potentially modifiable contributors to the incidence and severity of age-related hearing loss.
Biomass estimates and harvest strategies for the Western Australian Octopus aff. tetricus fishery
Authors: Hart Anthony M , Murphy Dave , Hesp S Alex , Leporati Stephen 
Published: July 2019

AbstractOctopus aff. tetricus is the target of Australia’s most significant octopus fishery. We utilized both fishery-independent surveys and fishery data from spatially detailed catch and effort logbooks to examine distribution and abundance across the spatial and depth ranges of the population. From this, a harvest strategy was developed to form the basis for monitoring, assessment, and management. Octopus aff. tetricus is abundant and widely distributed in Western Australia, with a biomass density range of 150–1000 kg km−2. This is comparable to Octopus vulgaris fisheries in the Mediterranean and sub-Saharan Africa. From an estimated habitat area of 20 073 km2, total biomass on the West Coast was estimated to be a minimum of 3600 tonnes whole weight with 90% certainty. At the current annual catch of 300 tonnes, overall population exploitation rate is low, given the high natural productivity of the species, which has a maximum age of 1.5 years and two recruitment pulses per year. A formal species name for O. aff. tetricus is required so its contribution to the Australian cephalopod fisheries harvest can be officially recognized.
Invariant States on Noncommutative Tori
Authors: Bambozzi Federico , Murro Simone , Pinamonti Nicola 
Published: July 2019

Abstract
For any number $h$ such that $\hbar :=h/2\pi $ is irrational and any skew-symmetric, non-degenerate bilinear form $\sigma :{{\mathbb{Z}}}^{2g}\times{{\mathbb{Z}}}^{2g} \to{{\mathbb{Z}}}$, let be ${{\mathcal{A}}}^h_{g,\sigma }$ be the twisted group *-algebra ${{\mathbb{C}}}[{{\mathbb{Z}}}^{2g}]$ and consider the ergodic group of *-automorphisms of ${{\mathcal{A}}}^h_{g,\sigma }$ induced by the action of the symplectic group $\textrm{Sp} \,({{\mathbb{Z}}}^{2g},\sigma )$. We show that the only $\textrm{Sp} \,({{\mathbb{Z}}}^{2g},\sigma )$-invariant state on ${{\mathcal{A}}}^h_{g,\sigma }$ is the trace state $\tau $.
Temperature Preference of Two Invasive Subterranean Termite Species and Their Hybrids (Blattodea: Rhinotermitidae: Coptotermes)
Authors: Patel Jayshree S , Chouvenc Thomas , Su Nan-Yao 
Published: July 2019

Abstract
Temperature preference of two invasive subterranean termites, Coptotermes gestroi (Wasmann) and Coptotermes formosanus Shiraki (Blattodea: Rhinotermitidae), and their hybrids were determined in a horizontal thermal gradient. The activity of workers of four mating combinations: ♀C. gestroi × ♂C. gestroi (C. gestroi), ♀C. formosanus × ♂C. formosanus (C. formosanus), ♀C. gestroi × ♂C. formosanus (Hybrid G), and ♀C. formosanus × ♂C. gestroi (Hybrid F), when placed on the temperature gradients were videotaped and analyzed to determine the mean temperature preference values (mTPV). The temperature ranges for active termites were 21.9–39.5°C for C. gestroi, 11.1–39.5°C for C. formosanus, 25.3–38.2°C for Hybrid G, and 24.9–39.3°C for Hybrid F. There was no significant difference in the mTPV of C. gestroi and both hybrid mating combinations. The mTPV of both Hybrid G and Hybrid F was significantly higher than the parental species C. formosanus. Our results indicate that hybrid populations of C. formosanus and C. gestroi might be more active in tropical than temperate regions, and if established in temperate regions, they will be more active in summer months when the mean temperature exceeds 25°C.
Momentum and energy injection by a supernova remnant into an inhomogeneous medium
Authors: Pittard J M 
Published: July 2019

ABSTRACT
We investigate the effect of mass-loading from embedded clouds on the evolution of supernova remnants and on the energy and momentum that they inject into an inhomogeneous interstellar medium. We use 1D hydrodynamical calculations and assume that the clouds are numerous enough that they can be treated in the continuous limit. The destruction of embedded clouds adds mass into the remnant, increasing its density and pressure, and decreasing its temperature. The remnant cools more quickly, is less able to do PdV work on the swept-up gas, and ultimately attains a lower final momentum (by up to a factor of two or more). We thus find that the injection of momentum is more sensitive to an inhomogeneous environment than previous work has suggested, and we provide fits to our results for the situation where the cloud mass is not limited. The behaviour of the remnant is more complex in situations where the cloud mass is finite and locally runs out. In the case of multiple supernovae in a clustered environment, later supernova explosions may encounter higher densities than previous explosions due to the prior liberation of mass from engulfed clouds. If the cloud mass is finite, later explosions may be able to create a sustained hot phase when earlier explosions have not been able to.
Radiative properties of the first galaxies: rapid transition between UV and infrared bright phases
Authors: Arata Shohei , Yajima Hidenobu , Nagamine Kentaro , Li Yuexing , Khochfar Sadegh 
Published: July 2019

ABSTRACT
Recent observations have successfully detected UV-bright and infrared-bright galaxies in the epoch of reionization. However, the origin of their radiative properties has not been understood yet. Combining cosmological hydrodynamic simulations and radiative transfer calculations, we present predictions of multiwavelength radiative properties of the first galaxies at z ∼ 6–15. Using zoom-in initial conditions, we investigate three massive galaxies and their satellites in different environment and halo masses at z = 6: $M_{\rm h}= 2.4\times 10^{10}\,$, $1.6\times 10^{11}\, $, and $0.7\times 10^{12}\, {\rm M_{\odot }}$. We find that most of the gas and dust are ejected from star-forming regions by supernova feedback, which allows the UV photons to escape. We show that the peak of the spectral energy distribution (SED) rapidly changes between UV and infrared wavelengths on a time-scale of ∼ 100 Myr due to intermittent star formation and feedback, and the escape fraction of UV photons fluctuates in the range of 0.2–0.8 at z &lt; 10 with a time-averaged value of 0.3. When dusty gas covers the star-forming regions, the galaxies become bright in the observed-frame sub-millimeter wavelengths. We predict the detectability of high-z galaxies with the Atacama Large Millimeter Array (ALMA). For a sensitivity limit of $0.1\, {\rm mJy}$ at $850\, {\rm \mu m}$, the detection probability of galaxies in haloes $M_{\rm h}\gtrsim 10^{11}\, \, {\rm M_{\odot }}$ at z ≲ 7 exceeds fifty per cent. We argue that supernova feedback can produce the observed diversity of SEDs for high-z galaxies.
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Management of Patients With Myelomeningocele: Whether Persistent Ventriculomegaly Adversely Impacts Neurocognitive Development
Authors: Blount Jeffrey P , Durham Susan R , Klimo Jr Paul , Assassi Nadege , Bauer David F , Beier Alexandra D , Flannery Ann Marie , McClung-Smith Catherine , Nikas Dimitrios C , Rehring Patricia , Tamber Mandeep S , Tyagi Rachana , Mazzola Catherine A 
Published: July 2019

AbstractBACKGROUNDMyelomeningocele (MM) is the most common congenital anomaly to affect the nervous system and affects 1500-2000 newborn infants per year in the United States. It is accompanied by symptomatic hydrocephalus in approximately 70%-80% of patients. Different treatment strategies for hydrocephalus characteristically result in different effects on the size of the ventricles.OBJECTIVEThe objective of this systematic review was to determine whether persistent ventricular enlargement adversely impacts neurocognitive development in patients with MM.METHODSThe PubMed National Library of Medicine Medline database and Embase were queried using MeSH headings and keywords relevant to neurocognitive or intellectual development and ventricular size or morphology. Abstracts were reviewed by the authors to identify which studies met strict inclusion criteria. An evidence table was constructed that summarized the included studies and reflected the quality of evidence (Classes I–III) that each represented. A recommendation was made that is based on the quality of the evidence.RESULTSAn initial abstract review utilizing strict inclusion/exclusion criteria yielded 48 studies, 9 of which underwent full-text review. There is limited and conflicting Class III evidence from 2 studies.CONCLUSIONCurrently, there is insufficient data to conclude that ventricular size and morphology impact neurocognitive development.The full guideline can be found at https://www.cns.org/guidelines/guidelines-spina-bifida-chapter-5.
Mechanisms of immune-related adverse events during the treatment of cancer with immune checkpoint inhibitors
Authors: Weinmann Sophia C , Pisetsky David S 
Published: July 2019

AbstractImmune checkpoint inhibitors are novel biologic agents to treat cancer by inhibiting the regulatory interactions that limit T cell cytotoxicity to tumours. Current agents target either CTLA-4 or the PD-1/PD-L1 axis. Because checkpoints may also regulate autoreactivity, immune checkpoint inhibitor therapy is complicated by side effects known as immune-related adverse events (irAEs). The aim of this article is to review the mechanisms of these events. irAEs can involve different tissues and include arthritis and other rheumatic manifestations. The frequency of irAEs is related to the checkpoint inhibited, with the combination of agents more toxic. Because of their severity, irAEs can limit therapy and require immunosuppressive treatment. The mechanisms leading to irAEs are likely similar to those promoting anti-tumour responses and involve expansion of the T cell repertoire; furthermore, immune checkpoint inhibitors can affect B cell responses and induce autoantibody production. Better understanding of the mechanisms of irAEs will be important to improve patient outcome as well as quality of life during treatment.
The Role of Personal Identity on Positive and Negative Symptoms in Psychosis: A Study Using the Repertory Grid Technique
Authors: García-Mieres Helena , Villaplana Anna , López-Carrilero Raquel , Grasa Eva , Barajas Ana , Pousa Esther , Feixas Guillem , Ochoa Susana 
Published: July 2019

Abstract

Background
People with psychosis experience disruptions in personal identity that affect positive and negative symptoms, but the complexity of these phenomena needs to be addressed in an in-depth manner. Using the Personal Construct Theory, we examined whether distinct dimensions of personal identity, as measured with the Repertory Grid Technique along with other cognitive factors, might influence psychotic symptomatology.

Method
Eighty-five outpatients with schizophrenia-spectrum disorders completed a repertory grid, an observed-rated interview of psychotic symptoms, and measures of cognitive insight, depressive symptoms, neurocognition, and theory of mind.

Results
Structural equation models revealed that interpersonal dichotomous thinking directly affected positive symptoms. Self-discrepancies influenced positive symptoms by mediation of depressive symptoms. Interpersonal cognitive differentiation and interpersonal cognitive richness mediated the impact of self-reflectivity and neurocognitive deficits in negative symptomatology.

Conclusions
This study is the first of its kind to examine the structure of personal identity in relation to positive and negative symptoms of psychosis. Results suggest interventions targeted to improving interpersonal dichotomous thinking, self-discrepancies, interpersonal cognitive differentiation, and interpersonal cognitive richness may be useful in improving psychotic symptoms.
A longitudinal analysis of albendazole treatment effect on neurocysticercosis cyst evolution using multistate models
Authors: Montgomery Michelle A , Ramos Marcel , Kelvin Elizabeth A , Carpio Arturo , Jaramillo Alexander , Hauser W Allen , Zhang Hongbin 
Published: July 2019

Abstract

Background
In neurocysticercosis, the larval form of the pork tapeworm Taenia solium appears to evolve through three phases—active, degenerative and sometimes calcification—before disappearance. The antihelmintic drug, albendazole, has been shown to hasten the resolution of active cysts in neurocysticercosis. Little is known about the time cysts take to progress through each phase, with or without treatment.

Methods
We reconfigured brain imaging data from patient level to cyst level for 117 patients in a randomized clinical trial of albendazole in which images were taken at baseline, 1, 6, 12 and 24 mo. Applying a multistate model, we modelled the hazard of a cyst evolving to subsequent cyst phases before the next imaging (vs no change). We examined the impact of albendazole treatment overall and by patient and cyst characteristics on the hazard.

Results
Albendazole accelerated the evolution from the active to degenerative phase (HR=2.7, 95% CI 1.3 to 6.5) and from the degenerative phase to disappearance (HR=1.9, 95% CI 1.1 to 3.9). Albendazole’s impact was stronger for patients who were male, did not have calcified cysts at baseline and who had multiple cysts in different locations.

Conclusions
This research provides a better understanding of where in the cyst trajectory albendazole has the greatest impact.
Evaluation and Management of Enterocutaneous Fistula
Authors: Bhama Anuradha R. 
Published: July 2019

Case Summary:
A 36-year-old woman presents with an abscess at her midline wound 4 weeks following an ileocecectomy for Crohn’s disease. After the abscess is incised, there is purulent drainage followed by the drainage of enteric contents; the output is 750 mL per 24 hours.
Cryopreservation of Stromal Vascular Fraction Cells Reduces Their Counts but Not Their Stem Cell Potency
Authors: Solodeev Inna , Orgil Matan , Bordeynik-Cohen Mor , Meilik Benjamin , Manheim Sharon , Volovitz Ilan , Sela Meirav , Inbal Amir , Gur Eyal , Shani Nir 
Published: July 2019

Background:
Adipose-derived stem cells are derived from the nonfat component of adipose tissue termed the stromal vascular fraction (SVF). The use of freshly isolated autologous SVF cells as an alternative to adult stem cells is becoming more common. Repeated SVF administration for improved clinical outcomes is complicated by the need for repeated liposuction. This can be overcome by cryopreservation of SVF cells. The current study aimed to assess whether SVF cells retain their stem cell potency during cryopreservation.

Methods:
SVF cells isolated from lipoaspirates (donor age: 46.1 ± 11.7 y; body mass index: 29.3 ± 4.8 kg/m2) were analyzed either immediately after isolation or following cryopreservation at −196°C. Analyses included assessment of nucleated cell counts by methylene blue staining, colony-forming unit fibroblast counts, surface marker expression using a flow cytometric panel (CD45, CD34, CD31, CD73, CD29, and CD105), expansion in culture, and differentiation to fat and bone.

Results:
While cryopreservation reduced the number of viable SVF cells, stem cell potency was preserved, as demonstrated by no significant difference in the proliferation, surface marker expression in culture, bone and fat differentiation capacity, and the number of colony-forming unit fibroblasts in culture, in cryopreserved versus fresh SVF cells. Importantly, reduced cell counts of cryopreserved cells were due, mainly, to a reduction in hematopoietic CD45+ cells, which was accompanied by increased proportions of CD45−CD34+CD31− stem cell progenitor cells compared to fresh SVF cells.

Conclusions:
Cryopreservation of SVF cells did not affect their in vitro stem cell potency and may therefore enable repeated SVF cell administrations, without the need for repeated liposuction.
History of Dose, Risk, and Compensation Assessments for US Veterans of the 1966 Plutonium Cleanup in Palomares, Spain
Authors: Beyea Jan , von Hippel Frank N. 
Published: July 2019

Abstract
In 1966, about 1,600 US military men—mostly Air Force—participated in a cleanup of plutonium dispersed from two nuclear bombs in Palomares, Spain. As a base for future analyses, we provide a history of the Palomares incident, including the dosimetry and risk analyses carried out to date and the compensation assessments made for veterans. By law, compensation for illnesses attributed to ionizing radiation is based on maximum estimated doses and standard risk coefficients, with considerable benefit of the doubt given to claimants when there is uncertainty. In the Palomares case, alpha activity in urine fell far faster than predicted by plutonium biokinetic excretion models used at the time. Most of the measurements were taken on-site but were disqualified on the grounds that they were “unreasonably high” and because there was a possibility of environmental contamination. Until the end of 2013, the Air Force used low dose estimates derived from environmental measurements carried out well after the cleanup. After these estimates were questioned by Congress, the Air Force adopted higher dose estimates based on plutonium concentration measurements in urine samples collected from 26 veterans after they left Palomares. The Air Force assumed that all other cleanup veterans received lower doses and therefore assigned to them maximum organ doses based on the individual among the 26 with the lowest urine measurements. These resulting maximum organ doses appear to be sufficient to justify compensation to all Palomares veterans with lung and bone cancer and early-onset liver cancer and leukemia but not other radiogenic cancers.
FOVEA-SPARING VERSUS COMPLETE INTERNAL LIMITING MEMBRANE PEELING IN VITRECTOMY FOR THE TREATMENT OF MACULAR HOLES
Authors: Morescalchi Francesco , Russo Andrea , Bahja Hassan , Gambicorti Elena , Cancarini Anna , Costagliola Ciro , Semeraro Francesco 
Published: July 2019

Purpose:
To compare the anatomical and functional outcomes of vitrectomy involving complete internal limiting membrane peeling (CP) with those of vitrectomy involving fovea-sparing internal limiting membrane peeling (FSP) for the treatment of macular holes measuring >250 µm.

Methods:
This prospective, randomized, comparative study included 46 eyes with a medium or large macular hole that was randomized to undergo complete (CP group) or fovea-sparing (FSP group) internal limiting membrane peeling during vitrectomy. The main outcome measures included the foveal retinal sensitivity, visual acuity, and central retinal thickness.

Results:
Both groups showed significantly improved foveal retinal sensitivity after surgery; the mean foveal retinal sensitivity change at 12 months after surgery was +2.8 ± 2.1 dB in the CP group and +7.2 ± 2.3 dB in the FSP group. The visual acuity also showed a significant improvement in both groups, with no significant differences in values at any time point. Regarding central retinal thickness, there was a significant decrease in the CP group and no change in the FSP group. Nicks or dimples in the inner retinal layers were visible in the fovea and perifovea of nine eyes in the CP group.

Conclusion:
Our findings suggest that both CP and FSP are safe and effective treatments leading to functional and anatomical improvements in patients with all size macular holes. However, the fovea-sparing technique may provide better functional outcomes because of a greater improvement in foveal retinal sensitivity.
FOVEAL OUTER RETINAL HYPERREFLECTIVITY: A NOVEL OPTICAL COHERENCE TOMOGRAPHY FINDING IN IDIOPATHIC MULTIFOCAL CHOROIDITIS
Authors: Dolz-Marco Rosa , Kalevar Ananda , McDonald H. Richard , Cunningham Emmett T. , Freund K. Bailey 
Published: July 2019

Purpose:
To describe three patients with idiopathic multifocal choroiditis (MFC) who showed foci of foveal outer retinal hyperreflectivity on optical coherence tomography.

Methods:
Retrospective review of electronic health records and multimodal imaging from three patients with MFC.

Results:
Three consecutive white patients with MFC (two male and one female) presented with unilateral foveal outer retinal hyperreflectivity in the eye with active MFC. In all cases, the lesions persisted for at least 1 month. Optical coherence tomography demonstrated finger-like projections of hyperreflectivity extending from the retinal pigment epithelium and through disrupted interdigitation and ellipsoid zones into the outer nuclear layer, with some aspects of the lesions reaching the inner limiting membrane. Visual recovery varied in the three affected eyes.

Conclusion:
Foveal outer retinal hyperreflectivity is a novel optical coherence tomography finding in eyes with active MFC. Additional studies will be required to address the prevalence and prognostic importance of foveal outer retinal hyperreflectivity.
DIMINUTIVE PARACENTRAL ACUTE MIDDLE MACULOPATHY LESION
Authors: Spaide Richard F. 
Published: July 2019

Purpose:
To describe a transient positive scotoma and corresponding optical coherence tomography (OCT) structural and angiographic findings.

Methods:
The patient was evaluated with a comprehensive ophthalmic examination to include OCT structural and angiographic imaging with two different instruments, the Zeiss Plex Elite and the Optovue RTVue XR Avanti.

Results:
A 45-year-old man had a sudden onset of a positive scotoma in the visual field of the left eye. No abnormalities were noted by ophthalmoscopy or fundus photography. Optical coherence tomography angiography was performed to evaluate the macular perfusion status. With each instrument, a small hyperreflective area, 175 μm in diameter, was imaged in the inner nuclear layer. The OCT angiographic images suggested a small area of decreased perfusion in the deep capillary plexus. Except for the diminutive size, the lesion had an appearance suggestive of paracentral acute middle maculopathy. The symptoms lessened rapidly, and when examined 4 days later, the lesion was less hyperreflective. Two weeks after presentation, the positive scotoma was not present and there was no longer any hyperreflectivity in the inner nuclear layer.

Conclusion:
Detection of the lesion was aided by using OCT angiographic scans, which have a much higher scan density than conventional OCT evaluations. The diminutive abnormality was consistent with a paracentral acute middle maculopathy lesion, although smaller than those previously reported. Micro–paracentral acute middle maculopathy lesions should be considered in the differential diagnosis of positive scotomas.