bluuebunny/crossref_metadata_2025_split huggingface dataset:
A AND B ANTIGENS IN HUMAN BONE TISSUE
Authors: Weinberg Haim , Makin Myer , Nelken David , Gurevitch Joseph 
Published: February 2018

1 . Sloughing of homogenous skin grafts and clouding of corneal transplants have been shown to be due to antigen-antibody reaction; antigens A and B have been demonstrated in human epidermis and corneal tissue; and anti-red-cell agglutination has been observed in dogs after homogenous bone transplantation. Human bone was therefore examined in thirty-three experiments to determine the presence or absence of A and B antigens. 2. The bone was separated into hard cortical bone, hard washed cancellous bone and soft-tissue washings of bone. 3. Adsorption experiments showed that A and B antigens are absent from cortical bone. A and B antigens are present in cancellous bone.
TRANSPLANTATION IMMUNITY IN BONE HOMOGRAFTING
Authors: Chalmers John 
Published: February 2018

1 . Fresh bone autografts to a muscle bed in the rat gave rise to vigorous new bone formation from about the fourth day. The graft took the form of a hollow ossicle with central bone marrow at eighteen days: it became progressively more regular in outline and was still present at six months. 2. Fresh bone homografts produced two separate phases of new bone formation–early and late. In the early phase non-lamellar woven bone appeared at about the fourth day, continued to grow until eight days, and subsequently died. It arose from osteogenic cells of the homograft. In the late phase, which developed in relation to a few grafts after four weeks, the new bone was lamellar in character, and remained closely applied to the graft surface. Evidence is presented that this bone arose by metaplasia of the host connective tissues at the graft site. There was a local inflammatory response to the bone homograft. 3. Both phases of homograft new bone formation were abolished if the animal was prepared by a skin homograft from the same donor four weeks before, but not if four months elapsed between the two grafting procedures. 4. Freeze-dried bone homografts did not give rise to the early phase of homograft new bone but produced a few examples of the late phase after five months. The inflammatory response was less intense with freeze-dried homografts than with fresh homografts. 5. Skin homografts three weeks after fresh bone homografts from the same donor underwent an early rejection at five to six days. 6. Skin homografts three weeks after freeze-dried bone homografts from the same donor had a mean survival time of twelve days, which was significantly longer than the mean survival time of l0·9 days in normal rats.
OSTEOTOMY OF THE CALCANEUM FOR PES CAVUS
Authors: Dwyer F. C. 
Published: February 2018

1 . A new surgical approach to the treatment of pes cavus is suggested. The operation consists in a subcutaneous division of the contracted plantar fascia and correction of the varus deformity of the heel by removing a wedge from its lateral aspect. It is submitted that, by approaching the deformity from behind and overcoming the varus of the heel, the foot is rendered plantigrade and that thereafter weight bearing exerts a corrective influence which results in progressive improvement of the deformity. The operation is essentially a prophylactic one and, for the best results, it should be performed before there is gross structural deformity and while active growth is still taking place. 2. Even in patients over the age of fourteen, improvement is obtained by doing nothing more than this simple operation. In the presence of fixed deformity of the forefoot, as encountered in older patients, inversion is corrected by removing a lateral wedge from the calcaneum and the cavus by taking a dorsal wedge from the tarso-metatarsal region. This has the double advantage of producing good correction of deformity, while at the same time preserving movement at the mid-tarsal-subtalar joint. Fixed clawing of the toes will require appropriate corrective treatment, but if the toes are malleable the simple effect of weight bearing on the plantigrade foot produces gradual correction.
OBSERVATIONS ON THE AMBULANT CORRECTION OF THORACIC SCOLIOSIS AND KYPHOSIS WITH PARTICULAR REFERENCE TO THE EXPERIMENTAL USE OF HYDROSTATIC PRESSURE
Authors: Bremner R. A. 
Published: February 2018

1 . The theoretical requirements for optimal correction of thoracic scoliosis and kyphosis are discussed, and observations are made on the limitations of methods in current use for their ambulant correction. 2. The experimental use of hydrostatic pressure in an endeavour to satisfy these clinical requirements is described. 3. It is suggested that the use of hydrostatic pressure as the source of corrective force has considerable advantages, and that, with refinements, the techniques described may prove a useful addition to rigid mechanical methods of correction.
CONGENITAL DYSPLASLA OF THE HIP
Authors: Leffmann Rudolf 
Published: February 2018

1. Eighty infants with congenital dysplasia of the hip, diagnosed before walking began, are reviewed. 2. The clinical and radiographic features of congenital dysplasia are described. 3. A dysplastic hip may either become normal spontaneously, or it may deteriorate to the state of true dislocation. 4. Treatment is discussed.
AN ANOMALOUS EXTENSOR INDICIS MUSCLE
Authors: Jones B. Victor , Ipswich R. N. 
Published: February 2018

1. A case is described in which the extensor indicis tendon was replaced by a short muscle arising from the soft tissues on the dorsum of the wrist. 2. The patient complained of pain in the hand after heavy use. This was considered to be due to constriction of the muscle by the extensor retinaculum. Division of the retinaculum was followed by a considerable improvement in his symptoms.
THE EFFECT OF CRUDE PAPAIN ON THE EPIPHYSIAL CARTILAGE OF LABORATORY ANIMALS
Authors: Hulth Anders , Westerborn Olle 
Published: February 2018

The present investigation has shown that crude papain can be used to produce rapid changes in the epiphysial cartilage of various young laboratory animals (rabbits, mice, rats, guinea pigs and cats). 1. Single injections of crude papain produce profound changes in the epiphysial cartilage. These changes disappear within a few days. They are radiographically visible as a narrowing of the epiphysial plates. Histologically, the formation of bony trabeculae in the primary spongiosa is found to be arrested. 2. Repeated injections of crude papain cause permanent damage to the epiphysial cartilage, often with bony closure. Consequently, the longitudinal growth of the injected animals, when compared to the controls, is found to be retarded or permanently arrested, and there may be severe bony deformity. 3. Using inactivated crystalline papain, we have been able to produce changes in the epiphysial cartilage identical with those caused by the injection of crude papain. 4. The injection of crude papain is dispelled by the addition of cysteine, but retains its full strength if hydrogen peroxide is added.
CALCIFICATION IN VITRO AND PHOSPHATASE ACTIVITY
Authors: Burger Martin , Sobel Albert E. 
Published: February 2018

The alkaline phosphatase activity of pre-osseous tibial cartilage of rachitic bone stored in the deep freeze for two weeks at -25 degrees centigrade was only slightly less than that of fresh controls from the same animals. The deep frozen pre-osseous tissue did not calcify in in vitro calcifying media containing either inorganic phosphorus or organic phosphate ester. The fresh controls calcified equally well in both media. In addition, after deep-freeze storage the tissue hydrolysed the organic phosphate to the same degree as did the fresh tissue. Bones heated at 65 degrees centigrade will calcify in vitro after calcium chloride treatment despite the destruction of phosphatase activity. It appears unlikely that a relationship exists between alkaline phosphatase and the minimal system required for calcification of pre-osseous cartilage in vitro. These findings do not exclude the possibility that alkaline phosphatase plays some critical role in vivo.
ARTHROPLASTY OF THE KNEE
Authors: Shiers L. G. P. 
Published: February 2018

1. The results of twenty-eight "hinge" arthroplasties of the knee are described. 2. Failure was most often due to breaking of the prosthesis. 3. The design of the prosthesis has been modified as a result of experience in cases of mechanical failure. 4. The results suggest that with the use of the modified hinge good results may be obtainable in three out of four cases.
VERTEBRAL GROWTH AND ITS MECHANICAL CONTROL
Authors: Roaf Robert 
Published: February 2018

1. Some of the factors responsible for vertebral growth have been discussed. 2. In kyphosis and scoliosis it is important to prevent progressive epiphysial damage. 3. In selected cases of progressive scoliosis, epiphysiodesis on the convex side will correct unequal growth. 4. The technique of spinal epiphysiodesis is described and the results that may be expected are discussed.
OSTEOSCLEROSIS AFTER INTERMITFENT ADMINISTRATION OF LARGE DOSES OF VITAMIN D IN THE RAT
Authors: Storey E. 
Published: February 2018

When large daily doses of vitamin D were administered to rats endochondral growth was inhibited and bone resorption occurred; later in the process uncalcified matrix (osteoid) like that seen in rickets formed on trabecular margins. When vitamin D was given only for a short period and then discontinued, little resorption of bone was seen during the withdrawal period and wide seams of osteoid material appeared which eventually calcified in an irregular manner. When normal endochondral growth was resumed a wide transverse band of dense bone with enclosed cartilaginous cores was left in the marrow cavity. If, after a few days, a second large dose of the vitamin was given resorption again occurred and calcification of osteoid material was accelerated, the first microscopic sign being a dense, wide, granular, deeply staining line at the junction of the bone and new osteoid. After a second withdrawal period a second layer of osteoid formed; eventually another transverse band appeared in the metaphysis. If this hypervitaminosis D cycle (+4 -12) was continued rats continued to form new bone with relatively little remodelling, so that after three such cycles bones became dense and hard. Histological study showed that little marrow cavity remained in either skull, vertebrae or epiphyses and a dense mass of bone enclosing cartilage cores filled the metaphysial part of the long bones. In addition, ankylosis ofteeth, calcification of spinal ligaments and widespread metastatic calcification were present. When hypervitaminosis D cycles (+1 -12, +1 -21) were adjusted to produce minimal resorptive changes a wide range of bone change was observed. This varied from uniform dense metaphysial bone containing abnormal cartilage matrix arranged in longitudinal striations, dense transverse bands parallel to the epiphysial cartilage, to remnants of dense trabeculae extending into the marrow cavity. Bone changes in osteopetrosis structurally closely resembled the induced bone changes in the rat. It is concluded that an important mechanism in the production of osteopetrosis is an accentuated rhythm of bone change like that shown experimentally to be produced in these animals. It is emphasised that these changes are but part of a range of bone disorders associated with abnormalities of cycles of resorption and deposition of bone, the type of change differing with the nature of the cycles.
ANALYSIS OF FORCES PRODUCING FRACTURES OF THE PROXIMAL END OF THE FEMUR
Authors: Hirsch Carl , Frankel Victor H. 
Published: February 2018

1. If a vertical load is applied to the head of the femur parallel to its shaft, the upper cortex is stretched and the lower cortex is compressed. The neck breaks from the upper subcapital border to the lesser trochanter. This type of fracture is rarely found clinically. 2. If a compressive force is applied to the area between head and greater trochanter while the head is loaded vertically, a transverse fracture of clinical appearance is produced. If this axial pressure acts along the part of the neck above the central axis a subcapital comminuted fracture results. If the pressure acts below the central axis the result is a transcervical fracture. 3. Strain gauge experiments have shown that axial compression within the upper segment of the neck is produced by the abductor muscles of the hip. Adductor muscles produce a low axial compression. It is suggested that muscular action at the time of injury influences the type of fracture produced by the injury.
THE BLOOD SUPPLY OF THE FEMORAL NECK AND HEAD IN RELATION TO THE DAMAGING EFFECTS OF NAILS AND SCREWS
Authors: Brodetti Alfredo 
Published: February 2018

1. Sixteen injected specimens of human femoral heads and necks, in which a nail or screw had been inserted, were examined. 2. The possibility exists that the fixing agent may interfere with the blood supply of the femoral head. The likelihood of this occurrence is not great. 3. The position of the fixing agent in which vascular damage is least likely is the central area or "neutral zone" of the femoral neck and head.
CELL DIVISION IN ENDOCHONDRAL OSSIFICATION
Authors: Kember N. F. 
Published: February 2018

1. The pattern of tritiated thymidine labelling in the cells of the epiphysial cartilage and metaphysis of the tibia in the rat is described for intervals of one hour to twenty-eight days after injection. 2. The region of dividing cells is defined and evidence given for a zone of reserve cells at the top of the cartilage columns. 3. The difficulties of quantitative grain count studies are discussed, and some approximate values are given for the generation time and mitotic cycle periods of the cartilage plate cells. 4. Some further evidence is given about the life cycles of the osteoblast and the osteoclast.
INTRATHECAL SPINAL TUMOUR AS A CAUSE OF COCCYDYNIA
Authors: Houlding R. Neville , Matheson A. T. 
Published: February 2018

1. Coccygeal pain in a young man, persisting for ten years in all and for seven years after partial removal of the coccyx, was shown to be due to an intrathecal tumour of the cauda equina. 2. Removal of the tumour, which was found to be an ependymoma, gave complete relief.
ASSESSMENT OF VERTEBRAL OSTEOPOROSIS BY RADIOGRAPHIC AND CHEMICAL METHODS POST-MORTEM
Authors: Caldwell R. A. , Collins D. H. 
Published: February 2018

1. Radiological, chemical and histological examinations have been made of the lumbar vertebral bodies in 100 necropsies on patients dying in a general hospital, with a view to determining the range of variation of calcium content and radiographic density in normal and osteoporotic bone. 2. Radiographs were made of sagittal mid-line vertebral body slabs uniformly one centimetre in thickness, and the radiographic density of these specimens was measured in relation to an aluminium step-wedge of one to ten units. Radio-opacity of different vertebrae ranged from four to ten units. The specimen radiographs also clearly revealed the trabecular structure and the lateral profile of the bones. 3. Calcium was chemically estimated and expressed as weight of the element per unit volume of the whole bone mass (that is, of anatomical bone including soft marrow tissue). It ranged from 38 to 102 milligrams per cubic centimetre of bone. In 75 per cent of the cases the range was 50-84 milligrams per cubic centimetre. High calcium values were mostly encountered in young adults, and the calcium per unit volume tended to diminish with age; but a wide range of calcium was still encountered in the older subjects and a better correlation with age was achieved by radiographic density. Both calcium content and radiographic density tended to be higher in the male than in the female bones at all ages. 4. The results of both calcium and radiographic density showed a smooth distribution curve, though skewed through the inclusion in the series of more older people with less mineralised bones; the absence of a double peak in these curves suggests that the examinations were made on a homogeneous population and does not indicate a separate pathological group of osteoporotic subjects. 5. Arbitrary standards must be used to distinguish osteoporotic from normal bones, since neither radiological measurement or chemical assay, nor histological assessment, reveals a point at which the two groups can be separated. In the present series it seemed to us satisfactory to regard as abnormal all bones showing a radiographic density of five or less step-wedge units, and by this standard nineteen of the 100 cases (eight male, eleven female) were deemed to be osteoporotic. Histological examination excluded other forms of bone rarefaction. 6. The regression of calcium on the density measurements proved to be statistically significant and was not affected either by age or by the number of days in bed during the last illness. A small difference between the sexes was apparent, there being slightly less calcium in female than in male bones of equal radiographic density. Provided this is taken into account, the radiographic density scale can be used to predict the calcium content of vertebral bone specimens and should prove a rapid and accurate method in a survey of osteoporosis in post-mortem room material.
THE MECHANICAL DISTURBANCES RESULTING FROM LUMBAR DISC SPACE NARROWING
Authors: Jonck L. M. 
Published: February 2018

1. In this investigation one was impressed by the close relationship that exists between the constituent parts of the intervertebral discs and the surrounding supporting structures. The part that is responsible for the maintenance of a co-ordinated balance between these structures, and hence for the effective mechanism of the spine, is the nucleus pulposus. 2. The cruciate arrangement of the annulus fibrosus is related to spinal function, and the angle of intersection of consecutive laminae of the annulus fibrosus is more or less constant. 3. In the Bantu it was found that the interspinous and supraspinous ligaments differ from the classical descriptions given in anatomical text-books. 4. The movements taking place between two vertebrae are comparable to those of a rocking-horse. 5. Narrowing of a disc is a progressive process which is the result of the disturbances in the balance between the components of the force to which a disc is subjected. The process is initiated by the loss of nucleus pulposus content. 6. With the approximation of two adjacent vertebrae a disturbance of the relations of the structures in the intervertebral foramen was noted. On anatomical grounds, when a disc is narrowed it appears that the most likely structures to cause pressure on the nerve root are not the disc itself, but the superior articular processes with their overlying ligamentum flavum.
AVASCULAR NECROSIS AFTER SLIPPING OF THE UPPER FEMORAL EPIPHYSIS
Authors: Lowe H. G. 
Published: February 2018

1. Avascular necrosis of the bony epiphysis or necrosis of the articular cartilage of the hip joint–without bony necrosis–can occur after a slipped upper femoral epiphysis. 2. In avascular necrosis of the bony epiphysis the prognosis depends upon the degree of revascularisation that occurs and upon survival of the articular cartilage. The articular cartilage can survive and a good functioning hip result especially if aided by mobilisation without weight bearing. 3. The prognosis after necrosis of the articular cartilage is poor. This complication occurs more often when conservative treatment is used. 4. A certain number of hips will show poor results no matter what treatment is used. 5. Nutrition of the articular cartilage is probably by the synovial fluid. 6. Strong traction may damage the soft-tissue structure of the hip joint. 7. It is not advisable to perform an osteotomy soon after a slip of the epiphysis. It is better to wait until good function is assured in the joint.
TIBIAL OSTEOTOMY FOR OSTEOARTHRITIS OF THE KNEE
Authors: Jackson J. P. , Waugh W. 
Published: February 2018

1. The results are presented of upper tibial osteotomy carried out in ten patients for osteoarthritis of the knee associated with lateral deformity. 2. The operation is indicated when there is severe pain, valgus or varus deformity, and a range of flexion of at least 90 degrees. 3. In every case pain has been relieved, and recovery of movement after operation has been easy.
KELLER'S ARTHROPLASTY MODIFIED
Authors: Thomas F. Brian 
Published: February 2018

1. A modification of the Keller's arthroplasty is described, in which one of two types of distractor–intramedullary wire and external staple–is used to maintain normal length of the great toe for three weeks after operation. 2. The results of the modified operation are analysed. They appear to show that the use of a distractor can be expected to produce an improved end result and to aid post-operative wound healing. 3. The possible reasons for the improvement in results are discussed. 4. The intramedullary wire and the external staple are compared with respect to ease of introduction, effectiveness in maintaining distraction and end results.
MUSCLE ACTION AND THE SHAPE OF THE FEMUR
Authors: Brookes M. , Wardle E. N. 
Published: February 2018

1. Femoral neck deformities that developed in patients under clinical observation are described. 2. Experiments made on ten decalcified femora produced similar deformities. 3. The two sets of observations are correlated and discussed with reference to the role of muscular imbalance in the causation of deformities of the femoral neck.
CAUSES AND TREATMENT OF NON-UNION IN FRACTURES OF THE RADIUS AND ULNA
Authors: De Buren N. 
Published: February 2018

1. The age of the patient has no influence on the incidence of non-union in fractures of the forearm in adults. 2. The degree of displacement of the fracture is an important factor in non-union, and is related to the violence of the injury. 3. Fractures of one bone unite better than fractures of both bones, and this is due to the stabilising effect of the intact bone. 4. Open and comminuted fractures have a much higher incidence of non-union. 5. The lowest incidence of non-union, allowances being made for other significant factors, was in cases treated conservatively; and after that in cases treated by plating followed by immobilisation in plaster. 6. Plating without subsequent immobilisation in plaster is a method to be abandoned, but there is some advantage in waiting for ten days, until post-operative oedema has been absorbed, before applying the plaster. 7. In cases in which several factors predisposing to non-union are present in the same patient, it seems justifiable to supplement plating by cancellous onlay strips as a primary procedure. 8. In cases of non-union the cancellous insert graft described by Nicoll succeeded in 94·5 per cent of the cases, many of which were exceptionally difficult problems. In 75 per cent union occurred within four months of grafting. 9. The restoration of mobility, either after union of the fracture or after grafting operations, was never a serious problem in the present series.
SPINAL DYSRAPHISM
Authors: James C. C. Michael , Lassman L. P. 
Published: February 2018

1. A syndrome resulting from congenital lesions affecting the spinal cord and cauda equina, associated with spina bifida occulta, is described. 2. The syndrome consists of a progressive deformity of the lower limbs in children. One foot and the same leg grow less rapidly than the other. The foot develops a progressive deformity which begins as a cavo-varus and becomes a valgus one. Both lower limbs may be affected. There may be progression to sensory loss, trophic ulceration, disturbance of function of bowel and bladder and even paraplegia. 3. Methods of investigation including myelography are described. 4. Exploration of the spinal cord has been undertaken in twenty-four patients so affected. Extrinsic congenital lesions causing traction or pressure or a combination of traction and pressure on the spinal cord have been found in twenty-two of these. 5. In two-thirds of the patients some degree of improvement has followed operation.