bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of maternal GBS colonization and early-onset neonatal disease rate for term deliveries: a decade perspective
Authors: Rottenstreich Misgav , Rotem Reut , Bergman Marva , Farkash Rivka , Schimmel Michael S. , Samueloff Arnon , Grisaru-Granovsky Sorina 
Published: February 2019

Abstract

Objective
To assess the maternal group B streptococcal (GBS) colonization rate and neonatal early-onset GBS (EOGBS) disease in term deliveries, a decade apart.

Methods
This was a retrospective computerized study between 2005 and 2016. A universal GBS culture-based approach gradually replaced the GBS risk-oriented screening. A vaginal-rectal culture taken at 35–37 weeks was recorded at admission for delivery.

Results
We identified 149,910 term deliveries during the study period. GBS status was recorded in 53,879 (35.9%) cases. The GBS screening rate constantly increased from 20% in 2005 to 47.5% in 2016. GBS colonization rates significantly decreased, from 50.3% in 2005 to 31.7% in 2016, P<0.001. Overall, EOGBS disease was diagnosed in 37 term neonates (0.25 per 1000 live births.). The rate of EOGBS in neonates decreased dramatically from 0.361 per 1000 deliveries between 2005 and 2009 to 0.19 per 1000 deliveries between 2010 and 2016 (P<0.05). During the latter period, over 35% of the deliveries were screened for GBS. Remarkably, 64.9% of the EOGBS originated in the non-screened population.

Conclusion
The universal screening policy was associated with a significant decrease in neonatal EOGBS and therefore should be adopted. Further national surveillance studies should be performed in order to validate this approach.
microRNA-1236-3p regulates DDP resistance in lung cancer cells
Authors: Wang Zhigang , Liu Limei , Guo Xiaofeng , Guo Chunmei , Wang Wenxia 
Published: February 2019

Abstract
Lung cancer is a malignant tumor leading to the most cancer-related deaths worldwide. The treatment efficiency of lung cancer remains poor mainly due to chemotherapy drug resistance, including cisplatin. MicroRNAs (miRNAs) are closely related to chemotherapy resistance of tumor cells. Here, we illustrated the underlying mechanism of miR-1236-3p on the DDP resistance in lung cancer cells. In this study, we found that the expression level of miR-1236-3p was significantly decreased in lung cancer tissues and A549 cell line. In addition, the half maximal inhibitory concentration (IC50) of DDP in A549 cells was significantly lower than that in A549/DDP cells, while the expression level of miR-1236-3p was prominently down-regulated in A549/DDP cells. Combining the online tool TargetScan and a dual-luciferase reporter assay, tumor protein, translationally-controlled 1 (TPT1) was proved to be the direct target gene of miR-1236-3p. The MTT and flow cytometry assays demonstrated that up-regulation of miR-1236-3p could markedly inhibit A549/DDP cell proliferation but promote apoptosis, which could be significantly reversed by pcDNA3.1-TPT1 plasmids. Finally, we further demonstrated that miR-1235-3p could restrain the expression levels of TPT1, Pim-3, phosphate-Bcl-2-associated death promoter (p-BAD) and B-cell lymphoma-extra large (Bcl-XL) in A549/DDP cells, while the inhibition could be reversed by pcDNA3.1-TPT1 as well. In a word, our study demonstrated that miR-1236-3p could reverse DDP resistance by modulation of TPT1 gene and inhibition of Pim-3 signaling pathway in lung cancer cells.
The link between thyroid autoimmunity, depression and bipolar disorder
Authors: Jucevičiūtė Neringa , Žilaitienė Birutė , Aniulienė Rosita , Vanagienė Virginija 
Published: February 2019

Abstract
Depression and bipolar disorder are two major psychiatric illnesses whose pathophysiology remains elusive. Newly emerging data support the hypothesis that the dysfunction of the immune system might be a potential factor contributing to the development of these mental disorders. The most common organ affected by autoimmunity is the thyroid; therefore, the link between autoimmune thyroid disorders and mental illnesses has been studied since the 1930s. The aim of this review is to discuss the associations between thyroid autoimmunity, depression and bipolar disorder.
Ionic transport and atomic structure of AgI-HgS-GeS2 glasses
Authors: Zaiter Rayan , Kassem Mohammad , Fontanari Daniele , Cuisset Arnaud , Benmore Chris J. , Bychkov Eugene 
Published: February 2019

Abstract

Quasi-ternary (AgI)
x
(HgS)0.5−

x

/2(GeS2)0.5−

x

/2 glasses, 10−4≤x≤0.6 were studied over a wide composition range covering nearly 4 orders of magnitude in the mobile cation content. The glasses show a remarkable increase of the ionic conductivity by 12 orders of magnitude and exhibit two drastically different ion transport regimes: (i) a power-law critical percolation at x≲0.04, and (ii) a modifier-controlled conductivity, exponentially dependent on x≳0.1. Using Raman spectroscopy and high-energy X-ray diffraction supported by DFT modelling of the Raman spectra we show that the glass network is essentially formed by corner-sharing CS-GeS4/2 tetrahedra. Mercury sulfide in glasses is dimorphic. The majority of Hg species (70% at x<0.2) exist as two-fold coordinated (HgS2/2)
n
chains. Silver species have mixed (2I+2S) tetrahedral environment forming either edge–sharing ES-Ag2I2S4/2 dimers or corner-sharing (CS-AgI2/2S2/2)
n
chains. The relationship between the ionic transport and atomic structure of the glasses is discussed.
Effect of aging conditions on the mechanical properties and antimicrobial activity of elastomer nanocomposites
Authors: Przybyłek Małgorzata , Białkowska Anita , Bakar Mohamed , Kosikowska Urszula , Szymborski Tomasz 
Published: February 2019

Abstract
The present study investigates the effect of thermooxidative and photooxidative aging on the mechanical and bactericidal properties of elastomer nanocomposites (ENs) based on Nanobent ZR2. The mechanical properties and morphologies were analyzed before and after aging. The addition of nanoparticles had a significant effect on the mechanical properties of ENs. Samples containing Nanobent exhibited higher tensile strength before and after aging compared to the reference composition. The addition of nanoparticles attenuated elastomer aging at elevated temperatures and ultraviolet light. Aged nanocomposites showed an inhibitory effect on the growth of bacteria and yeasts. Antibacterial and antifungal activity was only partially reduced after aging using physical methods compared to the activity of probes without aging. Scanning electron microscopy micrograph analysis showed different rough but homogeneous structures, confirming the uniform dispersion of the modified nanoparticles in the elastomer matrix as well as the retention of mechanical properties after the aging process.
Habituality in four Oceanic languages of Melanesia
Authors: von Prince Kilu , Krajinović Ana , Margetts Anna , Thieberger Nick , Guérin Valérie 
Published: February 2019

AbstractOur knowledge about tense, aspect and modality (TMA) in the Oceanic languages of Melanesia has so far been severely limited by the lack of available data. Habituality in particular, as one of the less described TMA categories, has not yet been widely discussed for this group of languages. Based on corpus data and elicitations, we give a detailed overview of four languages, identifying common trends and addressing specific questions of general concern. These include the relation of habituality to (im)perfectivity and the relation between habituality and irrealis.
Extended conjugation in stilbenoid squaraines
Authors: Meier Herbert 
Published: February 2019

Abstract
Squaraines, two-fold condensation products in 1,3-position of squaric acid, represent dyes or pigments of high actuality. After their first boom in electrophotography diverse applications are presently studied in a wide area of research, which reaches from electrooptical materials to biosensors and compounds used in photodynamic therapy. Absorption and/or emission ranges in the NIR are mandatory for many of these techniques. The present article deals with stilbenoid squaraines, which feature an extended conjugation in their biradicaloid D-π-A-π-D structure. Due to the charge-transfer character of the excitation, boundaries are set for the optimal length of the conjugation. The absorption maxima of the stilbenoid squaraines and their aggregates are lying in chloroform as a solvent between 600 and 1000 nm. In the solid state panchromatic absorptions can be observed, which reach far into the NIR region. The facile preparation of squaraines bearing stilbene building blocks in one or two of their arms and moreover the easy access to dyes with multiple squaraine units fixed to stilbenoid scaffolds promise a wide palette of further applications in materials science.
Crystal structure of Sc3Co1.64In4 and Sc10Co9In20 from single-crystal data
Authors: Gulay Nataliya , Tyvanchuk Yuriy , Daszkiewicz Marek , Stel’makhovych Bohdan , Kalychak Yaroslav 
Published: February 2019

Abstract
Two compounds in the Sc-Co-In system were obtained by arc-melting of the pure metals and their crystal structures have been determined using single crystal X-ray diffraction data. The structure of Sc3Co1.64In4 (space group P6̅, а=7.6702(5), c=3.3595(2) Å, Z=1, R
1=0.0160, wR
2=0.0301) belongs to the Lu3Co2−

x
In4 type structure, which is closely related to the ZrNiAl and Lu3CoGa5 types. The structure of Sc10Co9In20 (space group P4/nmm, а=12.8331(1), c=9.0226(1) Å, Z=2, R
1=0.0203, wR
2=0.0465) belongs to the Ho10Ni9In20 type, which is closely related to HfNiGa2.
On the Influence of Multiple Polarization Changes on the Cumulative Deformations in Sand Under Drained High-Cyclic Loading
Authors: Wichtmann T. , Triantafyllidis T. 
Published: February 2019

Abstract
The effect of multiple changes of the polarization (i.e., direction) of a drained cyclic loading has been studied in about 50 triaxial tests with simultaneous harmonic oscillation of the axial and lateral stresses. A fine sand has been tested at various initial densities. Starting from the same average stress in all the tests, six different polarizations of the cycles have been applied by choosing different amplitudes and phase shifts between the axial and lateral stress components. In each test, at least 10,000 cycles have been applied. The polarization has been changed every 1,000, 2,500 or 5,000 cycles. The sequence of the polarizations has been varied from test to test. Several reference tests without polarization changes have also been performed. The test results reveal that the first change of the polarization usually leads to a temporary increase of the rate of strain accumulation. This increase depends on the angle between the subsequent polarizations, while the correlation with the density or number of cycles applied prior to the polarization change is poor. All further polarization changes have only a minor effect on the rate of strain accumulation. Consequently, the final residual strain after 10,000 cycles is only moderately increased by the multiple polarization changes. The consequences of these experimental results for a high-cycle accumulation model describing the cumulative deformations in sand under a high-cyclic loading are briefly addressed.
Kartell der Algorithmen – das Verbot wettbewerbsbeschränkenden Zusammenwirkens im Lichte fortschreitender Digitalisierung bei der Preissetzung
Authors: Dück Hermann , Mäusezahl Steffen , Symnick Inga 
Published: February 2019

Zusammenfassung
Die fortschreitende Digitalisierung durchdringt zunehmend das gesellschaftliche Leben und wirtschaftliche Handeln. Entscheidungen werden in vielen Bereichen durch Algorithmen ausgeführt und gesteuert. Beispielsweise können Unternehmen dank Programmcodes Preise und Mengen optimieren, während Konsumenten die Möglichkeit haben, ihre Such- und Transaktionskosten mittels Vergleichsportalen zu verringern. Für den freien Wettbewerb und das Kartellrecht im Besonderen kann der unternehmerische Einsatz von Algorithmen eine Herausforderung darstellen, wenn hierdurch ein wettbewerbsbeschränkendes Zusammenwirken begünstigt wird. Abhängig vom Einsatzgebiet und der Funktionsweise lassen sich Algorithmen in unterschiedliche Kategorien einordnen, anhand derer das Gefahrenpotenzial und mögliche Gegenmaßnahmen beurteilt werden können. Technische Entwicklungen auf dem Gebiet der Künstlichen Intelligenz (KI) lassen bereits jetzt erahnen, dass der Faktor Mensch zukünftig weiter in den Hintergrund rücken wird und Entscheidungen autonom von Algorithmen getroffen werden könnten. Um den Handlungsrahmen für Kartellbehörden zu stärken, können Aspekte wie das Feststellen des Zusammenwirkens, die Zurechnung sowie die (Umkehr der) Beweislast in Betracht gezogen werden. Für den rechtskonformen Umgang mit Algorithmen kommt es aus Sicht von Unternehmen darauf an, welche Maßnahmen erforderlich sein können, um einen Rechtsverstoß zu verhindern. Dies schließt die Überlegung ein, ob die (angemessene) Nutzung von Algorithmen (hinsichtlich Auswahl und Design) in ein Compliance-Management-System eingebettet werden kann und falls ja, ob die Rechtsordnung ein derartiges System grundsätzlich anerkennen würde.
Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Opportunities and Challenges
Authors: Liu Xiufeng , Qin Shukui 
Published: February 2019

Abstract

Hepatocellular carcinoma (HCC) is the most common malignancy worldwide, and is especially common in China. A total of 70%–80% of patients are diagnosed at an advanced stage and can receive only palliative care. Sorafenib has been the standard of care for a decade, and promising results for regorafenib as a second-line and lenvatinib as a first-line treatment were reported only 1 or 2 years ago. FOLFOX4 was recently recommended as a clinical practice guideline by the China Food and Drug Administration. All approved systemic therapies remain unsatisfactory, with limited objective response rates and poor overall survival. Immune checkpoint inhibitors (CPIs) offer great promise in the treatment of a rapidly expanding spectrum of solid tumors. Immune checkpoint molecules are involved in almost the whole process of viral-related hepatitis with cirrhosis and HCC and in the most important resistance mechanism of sorafenib. The approval of nivolumab by the U.S. Food and Drug Administration on September 23, 2017, for the treatment of patients with HCC, based only on a phase I/II clinical trial, is a strong hint that immunotherapy will introduce a new era of HCC therapy. CPI-based strategies will soon be a main approach in anticancer treatment for HCC, and we will observe the rapid advances in the therapeutic use of CPIs, even in an adjuvant setting, with great interest. How shall we face the opportunities and challenges? Can we dramatically improve the prognosis of patients with HCC? This review may provide some informed guidance.
Comunicación digital en desarrollo turístico de la Isla Puná, Ecuador
Authors: Andrade Mendoza Karen Indira 
Published: February 2019

Este estudio pretende exponer la importancia de la comunicación digital e intercultural tanto para la conservación de los recursos naturales y la preservación del patrimonio cultural, como también la comunicación es prioritaria para potencializar actividades de desarrollo económico y social como el turismo, esto a través del reconocimiento y visualización de las comunidades por parte un público más amplio, con el uso de las diversas herramientas comunicativas que provee el internet y los espacios mediáticos.
Además, se caracterizará la riqueza natural y cultural existente en la Isla Puná, como artífice para un proceso de difusión de información y de ampliación de los canales de comunicación entre los diversos sectores productivos, sociales y culturales presentes en las dinámicas poblacionales de sus ciudadanos que la habitan.
OPTIMIZATION BUSINESS PROCESSES FOR TRANSITION TO A SUSTAINABLE DEVELOPMENT IN THE CONDITIONS OF THE FOURTH INDUSTRIAL REVOLUTION
Authors: Lisovsky A. L. 
Published: February 2019

The influence of technologies of the Industry 4.0 on optimization business processes of the industrial companies for achievement of a sustainable development is analyzed. Effects of the changes caused by technologies of the Industry of 4.0 in the Russian and foreign companies are considered. It is shown that achievement of a sustainable development is impossible without the process innovations caused by introduction of new technologies. The algorithm of carrying out audit and an assessment of the new technologies “business processes” most ready to introduction is offered for their introduction..
EVALUASI TATA KELOLA TEKNOLOGI INFORMASI E-KTP MENGGUNAKAN FRAMEWORK COBIT (STUDI KASUS : DINAS KEPENDUDUKAN DAN CATATAN SIPIL KABUPATEN BOGOR)
Authors: Kurniawan Dwi Tjahyo 
Published: February 2019

<p>Dinas Kependudukan dan Catatan Sipil Kabupaten Bogor (Disdukcapil) bertugas menjalankan sistem kependudukan elektronik kartu identitas (e-KTP). Metodologi yang digunakan berdasarkan kerangka kerja Control Objectives for Information and related Technology (COBIT) 4.1. COBIT merupakan framework yang menjembatani kesenjangan antara risiko dan masalah bisnis dengan teknis sehingga sistem informasi teknologi e-KTP berjalan sangat. Hasil analisis yang dilakukan di Dinas Kependudukan dan Catatan Sipil Kabupaten Bogor (Disdukcapil) menghasilkan nilai 2,48 yang berarti pada tingkat 2 (dapat diulang). Dinas Kependudukan dan Catatan Sipil Kabupaten Bogor telah memiliki pola untuk mengelola proses terkait berdasarkan keberhasilan pengalaman yang berulang yang pernah dilakukan sebelumnya tetapi pola yang dilakukan belum berstandar. Hasil tersebut menjadi dasar penentuan analisis gap serta rekomendasi yang diperlukan berdasarkan standar COBIT untuk Disdukcapil.</p>
GOOD CORPORATE GOVERNANCE FOR SHARIA MICRO FINANCIAL INSTITUTION
Authors: Mulato Tri 
Published: February 2019

Abstract
The growth of sharia financial institutions in Indonesia has experienced excellent growth, and has contributed to the development of the country. The existence of sharia financial institutions is increasingly in demand and many investors to develop sharia financial institutions. Without exception, sharia micro financial institutions consisting of BPRS and BMT. The account of BMT and BPRS continues to grow and experience growth, requiring governance in line with its character. This paper is qualitative, and uses descriptive qualitative analysis method, by describing the growth of sharia micro financial institution that is BPRS and BMT. Then describes the existing Good Corporate Governance (GCG) with BPRS and BMT. The results of this paper indicate that BPRS experienced good growth. Third Party Funds grew by 19.144% and financing grew by 14.862%, while the number of offices decreased by 0.222%. The BMT experienced 72.418 percent of receivables growth, 52.885 percent financing, and assets and placements grew below 40 percent. The concept of GCG with the five principles of Transparency, Accountability, Responsibility, Professional, and Fairness, fits perfectly with BPRS and BMT. It's just that it has different characters so it needs to be added the principle of partnership / friendship.
Keywords: Sharia of Financing Banking (BPRS), Baitul Maal Wattamwil (BMT), and Good Corporate Governance (GCG)
Abstrak
Pertumbuhan lembaga keuangan syariah di Indonesia mengalami pertumbuhan yang sangat baik, serta telah memberikan kontribusi untuk pembangunan negara. Keberadaan lembaga keuangan syariah semakin banyak diminati dan banyak investor untuk mengembangkan lembaga keuangan syariah. Tana terkecuali lembaga keuangan mikro syariah yang terdiri dari BPRS dan BMT. Jumlah BMT dan BPRS terus bertambah serta mengalami pertumbuhan sehingga membutuhkan tata kelola yang sejalan dengan karakternya. Tulisan ini bersifat kualitatif, dan menggunakan metode analisis deskriftif kualitatif, dengan menguraikan pertumbuhan lembaga keuangan mikro syariah yaitu BPRS dan BMT. Kemudian menguraikan Good Corporate Governance (GCG) yang sudah ada dengan BPRS dan BMT. Hasil dalam tulisan ini menujukkan bahwa BPRS mengalami pertumbuhan yang baik Dana Pihak ketiga tumbuh sebesar 19,144 persen dan pembiayaan tumbuh sebesar 14,862 persen, sedangkan jumlah kantor mengalami penurunan sebesar 0,222 persen. Adapun BMT mengalami pertumbuhan piutang sebesar 72,418 persen, pembiayaan 52,885 persen, dan aset serta penempatan tumbuh dibawah 40 persen. Konsep GCG dengan lima prinsip Transparansi, Akuntabilitas, Tanggungjawab, Profesional, dan Kewajaran, sangat cocok dengan BPRS dan BMT. Hanya saja memiliki karakter yang berbeda sehingga perlu ditambah prinsip kemitraan/silaturahim dalam kegiatannya.
Kata Kunci : Bank Pembiayaan Rakyat Syariah (BPRS), Baitul Maal Wattamwil (BMT), dan Good Corporate Governance (GCG)
Ekstraksi Kembang sepatu (Hibiscus Rosa Sinensis L) Menggunakan Pelarut Metanol dengan Metode Sokletasi untuk Indikator Titrasi Asam Basa
Authors: Riniati Riniati , Sularasa Ahya , Febrianto Anri Dwi 
Published: February 2019

Kembang sepatu merupakan tanaman hias yang tumbuh sepanjang masa dan banyak terdapat di daerah tropis. Ekstrak kembang sepatu diketahui dapat menunjukan hasil perubahan warna yang spesifik terhadap larutan asam maupun basa. Sifat ini dapat diterapkan sebagai indikator alami pengganti indikator sintetis yang harganya cukup mahal. Penelitian ini bertujuan untuk mengekstrak kembang sepatu kemudian memvalidasi penggunaan ekstrak tersebut sebagai indikator pada titrasi asam basa dengan pembanding indikator fenolftalein. Pelarut yang dipilih untuk ekstraksi antosianin dalam kembang sepatu pada penelitian ini yaitu metanol, dengan menggunakan metode sokletasi. Sokletasi dilakukan terhadap kelopak kembang sepatu yang sudah dikeringkan dan dipoton-potong pada kondisi suhu 68 oC dan dilakukan selama 15-20 siklus secara kontinyu. Ekstrak kemudian didistilasi dan di karakterisasi menggunakan FTIR selanjutnya diujicobakan sebagai indikator pada titrasi asam basa dengan pembanding indikator sintesis fenolftalein. Dari penelitian ini dapat disimpulkan bahwa ekstrak kelopak kembang sepatu menggunakan pelarut metanol dapat digunakan sebagai indikator titrasi asam – basa dengan perubahan warna dari merah ke hijau muda pada range pH 5-9 dan kestabilan warna terjaga selama rentang waktu minimal 8 minggu. Dari hasil pengujian koefisien korelasi diperoleh nilai R = 0,9992 dan nilai % recovery dari sebesar 101,16%, dimana nilai tersebut memenuhi standar metode validasi analisis kimia, dengan demikian indikator ini layak untuk digunakan sebagai pengganti indikator fenolftalein