bluuebunny/crossref_metadata_2025_split huggingface dataset:
CTA-guided outflow-targeted embolization of direct carotid-cavernous fistula
Authors: Liao Chih-Hsiang , Chen Wen-Hsien , Liao Nien-Chen , Tsuei Yuang-Seng 
Published: February 2019

This video presents a case of new-onset visual blurring, diplopia, and conjunctival injection after head injury. CTA of the brain revealed a direct carotid-cavernous fistula (dCCF) of the right side. Careful evaluation of CTA source images revealed that the fistula point was at the ventromedial aspect of the right cavernous internal carotid artery (ICA), about 3.6 × 3.6 mm2 in size, with 3 main outflow channels (2 intracranial and 1 extracranial) (CTA-guided concept). DSA of the brain also confirmed the diagnosis but was unable to locate the fistula point in a large-sized dCCF. Through a transfemoral artery approach, 3 microcatheters were navigated to each peripheral channel to initiate outflow-targeted embolization. Intracranial refluxes were blocked first to avoid cerebral hemorrhages, followed by the extracranial outflow. During embolization, accidental dislodge of one coil into the sphenoparietal vein occurred, but no attempt of coil retrieval was made. Complete obliteration of the dCCF was achieved, and the patient recovered well without new neurological deficits. 4D MRA at the 3-month follow-up showed no residual dCCF.The video can be found here: https://youtu.be/LH2lNVRZSPk.
Transarterial embolization of an internal maxillary artery arteriovenous fistula presenting with pulsatile tinnitus
Authors: Brinjikji Waleed , Cloft Harry J. , Lanzino Giuseppe , Rangel-Castilla Leonardo , Morris Pearse P. 
Published: February 2019

Arteriovenous fistulae of the internal maxillary artery are exceedingly rare, with less than 30 cases reported in the literature. Most of these lesions are congenital, iatrogenic, or posttraumatic. The most common presentation of internal maxillary artery fistulae is pulsatile tinnitus and headache. Because these lesions are single-hole fistulae, they can be easily cured with endovascular techniques. The authors present a case of a patient who presented to their institution with a several-year history of pulsatile tinnitus who was found to have an internal maxillary artery arteriovenous fistula, which was treated endovascularly with transarterial coil and Onyx embolization.The video can be found here: https://youtu.be/fDZVMMwpwRc.
Combined reconstructive and deconstructive endovascular approach for bilateral vertebral artery dissection with subarachnoid hemorrhage
Authors: Cherian Jacob , Madaelil Thomas P. , Tong Frank , Howard Brian M. , Cawley C. Michael , Grossberg Jonathan A. 
Published: February 2019

The video highlights a challenging case of bilateral vertebral artery dissection presenting with subarachnoid hemorrhage. The patient was found to have a critical flow-limiting stenosis in his dominant right vertebral artery and a ruptured pseudoaneurysm in his left vertebral artery. A single-stage endovascular treatment with stent reconstruction of the right vertebral artery and coil embolization sacrifice of the left side was performed. The case highlights the rationale for treatment and potential alternative strategies.The video can be found here: https://youtu.be/e0U_JE2jISw.
Introduction: Endovascular Neurosurgery
Authors: Levy Elad I. , Munich Stephan A. , Rosenwasser Robert H. , Kan Peter , Thompson B. Gregory 
Published: February 2019

Remarkable developments in the field of endovascular neurosurgery have been witnessed in the last decade. The success of endovascular therapy for ischemic stroke treatment is now irrefutable, making it an accepted standard of care. Endovascular treatment of cerebral aneurysms is no longer limited to primary coiling but now includes options such as stent or balloon assistance and flow diversion and applications utilizing neck reconstruction, intrasaccular, and bifurcation-specific devices. Balloons, liquid embolic agents, and flow-directed catheters have revolutionized the treatment of arteriovenous malformations and fistulae. The ongoing development of endovascular tools has led to novel and expanding approaches (for example, transvenous arteriovenous malformation embolization and transradial access). With improved technology, transposterior communicating artery access and other endovascular strategies are being applied successfully across the anterior and posterior circulations and to lesions once deemed only surgically approachable. Yet, we would be remiss to attribute the successes of endovascular strategies only to the development of their tools. Improvements in both noninvasive and angiographic imaging (such as three-dimensional road map guidance) have provided a greater understanding of pathologic entities and allowed the pursuit of endovascular cures.In this issue of Neurosurgical Focus, we present a wide range of endovascular strategies for a variety of neurovascular pathologies. We hope this video supplement will not only demonstrate the applicability of tried-and-true endovascular strategies to difficult clinical situations but also highlight new and developing endovascular technologies. We thank the authors for their outstanding contributions.
Prevenção da Mucosite Oral em Pacientes submetidos à Quimioterapia
Authors: Valduga Francielli , Oltramari Elenusa , Lemes Letícia Tainá de Oliveira , Mattos Carlos Eduardo de , Stefenon Letícia , Mozzini Carolina Barreto 
Published: February 2019

Introdução: A quimioterapia é uma das formas de tratar o câncer, na qual utilizam-se drogas como o 5-fluorouracil (5-FU), maior causador da mucosite oral. Essa complicação é a causa mais comum de dor. Objetivo: Avaliar o grau de mucosite oral durante os dez dias após cada ciclo de quimioterapia, segundo a autopercepção de cada paciente e o nível de dor relatada com o uso das duas substâncias estudo: chá de malva e clorexidina 0,12%. Método: Os pacientes foram randomizados por sorteio para a realização de bochechos com 10 ml da substância determinada, três vezes ao dia, durante o período de infusão da quimioterapia. Em cada ciclo, utilizou-se uma das substâncias. Durante os dez dias após a quimioterapia, os pacientes responderam a um questionário com perguntas fechadas sobre a sua dor e a autopercepção da sua mucosa oral. Resultados: Nos ciclos utilizando o chá de malva, a autopercepção do paciente pareceu ser melhor, com sua mucosite oral sendo de graus 1 e 2. Contudo, nos ciclos utilizando clorexidina 0,12%, os pacientes apresentaram menos dor. Conclusão: Tanto nos ciclos em que foi utilizado a clorexidina 0,12% quanto naqueles onde foi utilizado o chá de malva, a maioria dos pacientes referiu apresentar mucosite oral. Porém, quando utilizado o chá de malva, a frequência de mucosite foi em menores graus. A clorexidina 0,12% pareceu apresentar menos sintomatologia dolorosa, apesar da diferença, comparando as duas substâncias, ter sido pequena.
Estado Nutricional de Idosos Oncológicos por meio de Diferentes Métodos
Authors: Oliveira Lucivalda Pereira Magalhães , Anunciação Taise Andrade da , Costa Maria Lúcia Varjão da 
Published: February 2019

Introdução: O estado nutricional e a localização do tumor são essenciais na avaliação do idoso com câncer, pois relacionam-se com morbimortalidade e impactam diretamente na sobrevida. Objetivo: Avaliar o estado nutricional segundo a mini avaliação nutricional, índice de massa corporal e circunferência da panturrilha, identificar o grau de concordância entre esses parâmetros e verificar a associação entre o estado nutricional e os diferentes tipos de câncer. Método: Estudo transversal, com pacientes idosos oncológicos internados em um hospital de referência em Salvador, Bahia. Na coleta dos dados, utilizou-se a mini avaliação nutricional (versão reduzida), questionário estruturado para coleta de dados clínicos e perfil sociodemográfico, e antropométricos. Realizaram-se análise descritiva, teste de qui--quadrado (x²) e teste Kappa. Resultados: Observou-se que 41%, 54,3% e 74,3% dos pacientes apresentavam estado nutricional adequado segundo a mini avaliação nutricional, índice de massa corporal e circunferência da panturrilha, respectivamente, com uma concordância moderada (Kappa=0,59) entre índice de massa corporal e mini avaliação nutricional. Os maiores comprometimentos do estado nutricional foram observados nos pacientes com diagnóstico de câncer de cabeça e pescoço. Conclusão: Neste estudo, a mini avaliação nutricional foi mais sensível para identificar inadequação no estado nutricional quando comparada com o índice de massa corporal e circunferência da panturrilha; observou-se ainda associação entre o estado nutricional e a localização do tumor. Provavelmente, os parâmetros subjetivos da mini avaliação nutricional justificam o diagnóstico de desnutrição mais precoce, favorecendo a intervenção nutricional.
Aspectos Fonoaudiológicos em Pacientes Diagnosticados com Meningioma antes e após o Tratamento Cirúrgico
Authors: Costa Caroline Sousa , Scarpel Renata D’Arc , Jesus Ana Terra Brito de 
Published: February 2019

Introdução: Os meningiomas estão entre as neoplasias intracranianas primárias mais frequentes e, entre as deficiências neurológicas causadas, estão as alterações fonoaudiológicas, principalmente os déficits de deglutição e comunicação. Com isso, estudos que identifiquem precocemente as alterações fonoaudiológicas são necessários para uma adequada intervenção terapêutica. Este estudo tem como objetivo descrever os aspectos fonoaudiológicos em pacientes diagnosticados com meningioma antes e após o tratamento cirúrgico. Relato dos casos: Participaram da pesquisa seis indivíduos diagnosticados com meningioma internados em um hospital geral de Salvador - BA. Os participantes foram submetidos à avaliação fonoaudiológica antes e após a ressecção do tumor, com aplicação do Protocolo de avaliação clínica fonoaudiológica à beira leito. No momento pré-cirúrgico, as alterações fonoaudiológicas ocorreram em um número pequeno de casos, estando relacionadas principalmente a déficits leves de motricidade orofacial e disfagia de leve a moderada. Já no período pós-operatório, as alterações fonoaudiológicas foram frequentes, principalmente quanto à deglutição, com involução da Escala funcional de ingestão por via oral e necessidade de terapia fonoaudiológica em todos os casos. Conclusão: Conclui-se que o meningioma pode acarretar diferentes alterações fonoaudiológicas, principalmente quanto à deglutição, sendo mais frequente no momento pós-cirúrgico em razão da manipulação dos vasos e nervos, e mais preocupante em regiões cranianas posteriores.
Dia Mundial sem Tabaco e Dia Nacional de Combate ao Fumo Catálogo de Campanhas 1997-2017
Authors: Cardoso Andréa Ramalho Reis 
Published: February 2019

Esta publicação realiza um resumo histórico das campanhas (Dia Mundial sem Tabaco e Dia Nacional de Controle do Tabagismo), coordenadas pelo Instituto Nacional de Câncer José Gomes de Alencar (INCA/MS), que, desde o final da década de 1980, sob a ótica da promoção da saúde, é o responsável pela gestão e governança do controle do tabagismo no Brasil coordenando um conjunto de ações nacionais específicas que compõem o Programa Nacional de Controle do Tabagismo (PNCT).
MELADERM-trial: Melatonin cream against acute radiation dermatitis in patients with early breast cancer
Authors: Zetner Dennis , Kamby Claus , Mahmood Faisal , Rosenberg Jacob 
Published: February 2019

Radiation
dermatitis following radiation therapy in the treatment of early breast cancer
can lead to discontinuation or prolongation of treatment and an impaired
quality of life. Melatonin has been demonstrated to protect against radiation
injury. The aim of this study is to investigate whether melatonin can protect
against radiation dermatitis when applied topically in women receiving
radiation therapy for early breast cancer. This study will be a randomized,
placebo-controlled, double-blind controlled trial. Patients will apply the
melatonin or placebo preparation topically twice daily for the duration of
their radiation therapy. Our objective outcomes will be the Radiation Therapy
Oncology Group’s acute radiation morbidity scoring criteria for skin, image
analysis of clinical photographs, and use of steroid cream for radiation
dermatitis. Subjective outcomes will be quality of life questionnaires
developed by the European Organisation for Research and Treatment of Cancer.
Outcomes will be measured throughout the five weeks of radiation treatment and
be followed up for another three weeks. According to sample-size calculations
and inclusion schedule, we intend to include a total of 80 evaluable patients. We
will analyze the primary outcomes using parametric and non-parametric tests
where applicable. Secondary outcomes will be analyzed by a mixed linear model. Most
patients with breast cancer who undergo radiation therapy will develop
radiation dermatitis as a result of the therapy. Should our intervention
provide better outcomes, many patients could obtain a better quality of life.
We expect topical melatonin treatment to have little or no adverse effects, to
be easy to apply, and not to interfere with the anti-tumor efficacy of the
radiation therapy.
Melatonin and chromatin
Authors: Hardeland Ruediger 
Published: February 2019

Melatonin
affects chromatin remodeling, thereby activating or silencing specific genes
and, presumably, also by modulating circadian-mediated changes in chromatin
structure. Melatonin has been shown to exert effects on chromatin under
conditions of toxin exposure, treatment with other hormones such as glucocorticoids
or leptin, in cancer, and during developmental processes. Most of the
documented actions concern histone modifications or their reversal that facilitate
or prevent nucleosome eviction. Less information is available on DNA
methylation or demethylation at regulatory CpG islands. To date, this has been
mainly studied under conditions of early development, occasionally concerning seasonality
or shiftwork with light at night. Another emerging field, which is still
insufficiently studied, concerns regulation via DNA-interacting noncoding RNAs,
in particular, super-enhancer lncRNAs. Although the direct information on
actions by melatonin is widely missing, this field promises to become
important, as numerous RNAs of this type have been shown to be rhythmically
expressed. The circadian aspect of melatonin’s role in chromatin remodeling and
control of gene expression deserves future attention. This includes the role of
sirtuin 1, which participates in the circadian machinery and apparently
mediates several effects of melatonin that are suppressed by sirtuin inhibitors
or sirtuin 1 knockdown.
El Proyecto Europeo de Computación Avanzada
Authors: Casanova Juanes Julieta 
Published: February 2019

El Proyecto Europeo de computación avanzada, articulado en la Empresa Común de Informática de Alto Rendimiento Europea, desde julio de 2018 y hasta 2026, establece como objetivo la creación de un ecosistema europeo de supercomputación competitivo y de nivel de exascala en 2022-2023, que sitúen a Europa entre las tres potencias mundiales en supercomputación y contribuyan a construir una Europa más competitiva y con más oportunidades para todos los agentes económicos en el marco de la revolución digital de la economía. España ha sido precursora del Proyecto de computación avanzada desde sus orígenes. La tradición de apoyo del país a la supercomputación y la excelencia internacional del Barcelona Supercomputing Center-Centro Nacional de Supercomputación determinarán el papel estratégico de España en la Empresa Común y su candidatura junto a otros socios naturales estratégicos, a albergar en el Centro Nacional de Supercomputación una de las máquinas pre-exascala previstas por la Empresa Común.
El Fondo Monetario Internacional en la encrucijada. La Decimoquinta Revisión General de Cuotas y otras propuestas de reforma en un sistema financiero internacional en transición
Authors: Sistema Financiero Internacional Subdirección General del 
Published: February 2019

En este artículo se analiza la situación en el momento presente del Fondo Monetario Internacional como institución en términos de recursos y gobernanza, junto con unas referencias puntuales a los principales mensajes sobre la situación de la economía global de las últimas asambleas de octubre de 2018.
Para ello, el foco se centra en dos propuestas recientes de reforma del Fondo desde el ámbito académico (última edición del Geneva Report de 2018) y desde el G20 (informe presentado por el Eminent Persons Group en octubre de 2018) y, particularmente, en los principales aspectos de la Decimoquinta Revisión General de Cuotas de la institución, actualmente en curso y que ha de ser concluida como muy tarde en las asambleas anuales de octubre de 2018.
Del resultado de este proceso de reforma depende en gran medida que el FMI permanezca en el centro de la red de seguridad del sistema financiero internacional.
PENGARUH DUKUNGAN KELUARGA TERHADAP TINGKAT DEPRESI PADA LANJUT USIA DI DAERAH ISTIMEWA YOGYAKARTA
Authors: Inayati Aini , Ichsani Dwiky Imam 
Published: February 2019

Background: The elderly is the final stage of the human life cycle, today the depression in elderly is an interaction of biological, psychological and social factors. Social factors are decreasing social interaction, loneliness, mourning and poverty can trigger depression. Objective: To determine the effect of family support on the level of depression in elderly in Yogyakarta Method: This study used quantitative research design with cross sectional approach. The sample used was 97 elderly who met the criteria for inclusion and exclusion. Sampling in this study used purposive sampling with data analysis using SPSS 17.0. Results: The results of the Spearman Rank test obtained a significance value (2-tailed) with a result of 0.001 which means 0.001 <0.05, then H1 is accepted meaning that there is a significant relationship between family support with the level of depression in elderly in Nganglik, Sleman, Yogyakarta. While the level of depression in elderly found mild depression 18.6% (18 responses), moderate depression as much as 78.4% (76 respondents) and major depression as much as 3.1% (3 respondents).
Conclusion: Family support is very beneficial in controlling depression of the elderly and also reduce the pressures that exist in conflicts that occur in the elderly. Family support is related to the formation of mental balance and psychological satisfaction. Support is obtained from families consisting of husband or wife, children, grandchildren, siblings, or close relatives of the elderly.
The reality of smart city development management in the comprehensive development plan for the city of Baghdad 2030
Authors: الشيخلي عبد الرزاق ابراهيم , علوان نوال عبد الكريم 
Published: February 2019

Abstract
Abstract has many advantages as has historically been one of the regions leading cultural centers . for centuries , it has been a center of commertial and financial operations in Iraq. it is also rich in archeological sites and natural resources, but because of its wars and implementation of urban development strategies are effective and sustainable , so contracted the secretariat of Baghdad with the company (khatib and scirntiffic) for the preparation of the comprehensive development plan for the city of Baghdad in 2030 and funded by the world bank and the fact that the plan was approved ( three stages of it ) and only one phase remains the fourth stage, which is under discussion the aim of the research is to identify the extent to which it is oriented towards the smart cities approach that the cities of the world are dealing with today through a sample representing the consultative team of the comprehensive plan of the city of Baghdad 2030 and its supporters in the municipality of Baghdad which number (51) people tha data was collected by means of several tools, namely, questionnaire and personal inter views and a number of statistical methods were used to process the information including the comparative rations of the empirical analysis to test the hypotheses of the study, which states that there is a significant correlation between the study variables, there was a significant correlation between the study variable varibles, the effects of significant significance among the variables of all study and the study reached a set of conclusions, the most important of which is the comprehensive development plan for the city of Baghdad requires the integration of all its vocabulary with in the development of smart cities
مقارنة بين طريقة المربعات الصغرى الجزئية وخوارزمية تجزئة القيم المفردة لتقدير معلمات أنموذج الانحدار اللوجستي في حالة وجود مشكلة التعدد الخطي بأستعمال المحاكاةg
Authors: حسن محمود مهدي , شاكر هديل حميد 
Published: February 2019

يعد أنموذج الانحدار اللوجستي من النماذج الاحصائية المهمة حيث يوضح العلاقة بين المتغير التابع ثنائي الاستجابة والمتغيرات التوضيحية (التفسيرية).
أن العدد الكبير لمتغيرات توضيحية تستعمل عادة لتوضيح الاستجابة ادى الى ظهور مشكلة التعدد الخطي(Multicollinearity) بين المتغيرات التوضيحية التي تجعل تقدير معلمات النموذج ليست دقيقة.
تم في هذا البحث استعمال طرائق لتقدير معلمات أنموذج الانحدار اللوجستي في حالة وجود مشكلة التعدد الخطي وهذه الطرائق هي طريقة انحدار المربعات الصغرى الجزئية(PLSR) و خوارزمية تجزئة القيم المفردة(SVD), اذ تم استخدام اسلوب المحاكاة للمقارنة بين طرائق التقدير من خلال متوسط مربعات الخطأ(MSE) للأنموذج.
واتضح من خلال المقارنة أن خوارزمية تجزئة القيم المفردة (SVD) هي الافضل في تقدير معلمات أنموذج الانحدار اللوجستي في حالة وجود مشكلة التعدد الخطي.
مقارنة بين طرائق انحدار الحرف ونوع ليو في تقدير معلمات أنموذج انحدار ثنائي الحدين السالب في ظل وجود مشكلة التعدد الخطي باستخدام المحاكاة
Authors: عبود سهيل نجم , خورشيد ايناس صلاح 
Published: February 2019

ان مشكلة التعدد الخطي من المشاكل الشائعة والتي تتعامل الى حد كبير مع الارتباط الداخلي بين المتغيرات التوضيحية وتظهر هذه المشكلة خصوصا في الاقتصاد والبحوث التطبيقية، ويكون لمشكلة التعدد الخطي تاثير سلبي على أنموذج الانحدار مثل وجود درجة تباين متضخم وتقدير معلمات تكون غير مستقرة عندما نستخدم مقدرات المربعات الصغرى الاعتيادية (OLS) ، لهذا تم اللجوء الى استخدام طرائق اخرى لتقدير معلمات أنموذج ثنائي الحدين السالب منها طريقة مقدر انحدار الحرف ومقدر نوع ليو، ويعتبر أنموذج انحدار ثنائي الحدين السالب (Negative Binomial Regression Model) كأنموذج انحدار غير خطي او كجزء من العائلة الاسية المعممة و هذا ألانموذج الهيكل الاساسي لتحليل بيانات العد (Count Data) و الذي استخدم كبديل لنموذج بواسون عندما تكون هناك مشكلة فوق التشتت (Overdisperison) اي عندما تكون قيمة تباين متغير الاستجابة (Y) اكبر من وسطه الحسابي ، وتم تصميم دراسة محاكاة مونت كارلوا للمقارنة بين طريقتي تقدير انحدار الحرف (Ridge Regression Estimator) ومقدر نوع ليو (Liu Type Estimator) من خلال استخدام معيار مقارنة متوسط مربعات الخطأ (MSE)، حيث بينت نتيجة المحاكاة ان طريقة مقدر نوع ليو هي افضل من طريقة مقدر انحدار الحرف اذ جاءت متوسط مربعات الخطأ لها اقل في صيغته التقديرية الثالثة والرابعة .
Comparison between normal weights and conditional Bays weights in Iterative principal component estimators
Authors: شمال اياد حبيب 
Published: February 2019

Abstract:
This paper discusses the problem of semi maulticollinearity in the nonlinear regression model (the multi-logistic regression model) When the dependent variable is a qualitative variable, the binary response is either equal to one for a response or zero for no response, Through the use of Iterative principal component estimatorsWhich are based on the normal weights and conditional Bays weights .
If the appliede Estimates this model Through the use of two types of drugs concentrations thy concentration of ciprodar (variable X1) On a number of people with Patients with renal disease represent the dependent variable (The person heals from the disease , The person has not recovered from the disease )from through Mean Error Squares (MSE) The results were indicative of Iterative principal component estemaite Depending on the conditional Bays weights prefer the Iterative principal component estimators Depending on the the normal weights.