bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Empirical Examination of Nursing Units in China Based on Nurse Experience
Authors: Xuan Xiaodong , Li Zongfei , Chen Xixi 
Published: July 2018

Objectives: To create opportunities to increase nursing staff’s satisfaction and operational efficiency and eventually improve nurses’ experiences through better design in unit layout. Background: The majority of research performed on nursing units in China only focused on the spatial design itself, and few studies examined the nursing unit empirically based on nurses’ experience. Nursing units need to be designed with understanding nurses’ behavior and experience in China. Method: A mixed-method approach was conducted in four double-corridor nursing units in China. Observation and interview data were collected to explore how physical environments for managing administrative duties, medications, and caring patient were used in nursing units. Results: The most frequent activities were communication, medication, and patient-care activities. The places in which nurses spent the most of theirs working times were the nurse station (NS), patient room, workstation on wheels (WoW), and medication room. The important clinical work spaces were the patient room, NS, WoW, medication room, doctor’s office, disposal room, examining room, and back corridor. The important traffic linkages were between NS and medication room, patient room and WoW, and medication room and patient room. Conclusions: This article revealed the frequency of nurse activities; how they spent their time; how they use the clinical spaces; identified important clinical spaces, linkages, and driver of inefficiency in nursing work and nursing unit design; and finally generated recommendations for double-corridor nursing unit design in China which can be used by medical planner, hospital administrator.
Timing of Intra-Articular Injection of Synovial Mesenchymal Stem Cells Affects Cartilage Restoration in a Partial Thickness Cartilage Defect Model in Rats
Authors: Enomoto Takahiro , Akagi Ryuichiro , Ogawa Yuya , Yamaguchi Satoshi , Hoshi Hiroko , Sasaki Toshihide , Sato Yusuke , Nakagawa Ryosuke , Kimura Seiji , Ohtori Seiji , Sasho Takahisa 
Published: July 2018

Objective We investigated the effect of administration of intra-articular mesenchymal stem cells (MSCs) on cartilage repair at different timings, and the distribution of MSCs in the knee. Design A partial thickness cartilage defect (PTCD) was created on the medial femoral condyle in 14-week-old Sprague-Dawley rats. Intra-articular injection of 1 × 106 MSCs was performed at 3 time points, namely at the time of surgery (0w group), at 1 week after surgery (1w group), and at 2 weeks after surgery (2w group). For the control, 50 μL phosphate-buffered saline was injected at the time of surgery. The femoral condyles were collected at 6 weeks after creation of PTCD and assessed histologically. To investigate the distribution of MSCs, fluorescent-labeled MSCs were injected into the knee joint. Results In the control group, the cartilage lesion was distinguishable from surrounding cartilage. In the 0w group, hypocellularity and a slight decrease in safranin O stainability were observed around the injured area, but cartilage was restored to a nearly normal condition. In contrast, in the 1w and 2w groups, the cartilage surface was irregular and safranin O stainability in the injured and surrounding areas was poor. Histological score in the 0w group was significantly better than in the control, 1w, and 2w groups. At 1 day postinjection, fluorescent-labeled MSCs were mostly distributed in synovium. However, no migration into the PTCD was observed. Conclusions Early intra-articular injection of MSCs was effective in enhancing cartilage healing in a rat PTCD model. Injected MSCs were distributed in synovium, not in cartilage surrounding the PTCD.
Effect of a multifaceted stewardship intervention on antibiotic prescribing and outcomes for acute bacterial skin and skin structure infections
Authors: Roshdy Danya , Jaffa Rupal , Pillinger Kelly E. , Guffey Josh , Rozario Nigel , Davidson Lisa , McCurdy Lewis 
Published: July 2018

Background: Acute bacterial skin and skin structure infections (ABSSSI) are a leading cause of hospitalization, but are often treated inappropriately in the inpatient setting. A multifaceted stewardship intervention was implemented to encourage prescribing of guideline-concordant therapy (GCT). Objective: To examine the impact of this initiative on antimicrobial prescribing practices and patient outcomes. Methods: This was a single-center, retrospective study of adult inpatients admitted with a primary or secondary diagnosis of ABSSSI, classified by type and severity based on signs of systemic infection. Patients treated during the pre-intervention period (pre-IP) were compared with patients treated during the post-intervention period (post-IP). The primary endpoint was receipt of GCT. Secondary endpoints included receipt of anti-anaerobic antibiotic (AAA) or broad-spectrum antibiotics (BSA). Results: A total of 125 patients were included, 64 in the pre-IP and 61 in the post-IP. There was a statistically significant increase in prescribing of GCT during the post-IP compared with the pre-IP (14% versus 56%, p < 0.0001) and a decrease in use of AAA (56% versus 34%, p = 0.01). No difference was observed with use of BSA (16% versus 15%, p = 0.89). Use of the computerized order set during the post-IP was low (18%). There was a numerical, but non-significant reduction in 30-day readmission (14.1% versus 6.6%, p = 0.17). Conclusion: The multifaceted intervention was effective for improving prescribing of GCT for ABSSSI. Given low use of the computerized order set, improved prescribing seemed to be driven by provider education. Strategies around ongoing education may be key to sustain positive results of stewardship interventions.
Behavior change techniques in mobile applications for sedentary behavior
Authors: Dunn Emily E , Gainforth Heather L , Robertson-Wilson Jennifer E 
Published: July 2018

Objective Mobile applications (apps) are increasingly being utilized in health behavior change interventions. To determine the presence of underlying behavior change mechanisms, apps for physical activity have been coded for behavior change techniques (BCTs). However, apps for sedentary behavior have yet to be assessed for BCTs. Thus, the purpose of the present study was to review apps designed to decrease sedentary time and determine the presence of BCTs. Methods Systematic searches of the iTunes App and Google Play stores were completed using keyword searches. Two reviewers independently coded free ( n = 36) and paid ( n = 14) app descriptions using a taxonomy of 93 BCTs (December 2016–January 2017). A subsample ( n = 4) of free apps were trialed for one week by the reviewers and coded for the presence of BCTs (February 2017). Results In the free and paid app descriptions, only 10 of 93 BCTs were present with a mean of 2.42 BCTs (range 0–6) per app. The BCTs coded most frequently were “prompts/cues” ( n = 43), “information about health consequences” ( n = 31), and “self-monitoring of behavior” ( n = 17). For the four free apps that were trialed, three additional BCTs were coded that were not coded in the descriptions: “graded tasks,” “focus on past successes,” and “behavior substitution.” Conclusions These sedentary behavior apps have fewer BCTs compared with physical activity apps and traditional (i.e., non-app) physical activity and healthy eating interventions. The present study sheds light on the behavior change potential of sedentary behavior apps and provides practical insight about coding for BCTs in apps.
Cournot-like Interaction with Cournot Outcomes
Authors: Soldatos Gerasimos T. 
Published: July 2018

This article works out a Cournot duopoly where firms take price as given, but it is not the same price that is taken for given by each firm; it depends on individual expectations about opponent’s behaviour as are shaped by the business cycle. Yet, the result of this interaction is a Cournot equilibrium as if the calculations were based on the same price. It is not the price that would be assumed in the absence of expectations. Expectations make inverse-U-shaped reaction curves peak at higher output levels relative to peaks in their absence, implying a lower price vis-à-vis that which is taken for granted in the traditional analysis. And, output levels are higher because they reflect optimism for the course of the economy. In the static context of the analysis, a Cournot equilibrium comes about as if the business cycle is at each peak. Policy-wise, the message is that observed price variations in an oligopoly do not necessarily indicate Bertrand competition despite the possibility that dynamic interaction may lead to outcomes other than the Cournot one; but it will be about disequilibrium and unstable outcomes. JEL Classifications: D43, L13, E32
Acute Fixation of Type IV and V Acromioclavicular Separations: An Internal Splint Technique
Authors: LaMartina Joey A. , Lau Brian C. , Miller Liane , Salesky Madeleine A. , Feeley Brian T. , Ma C. Benjamin , Zhang Alan L. 
Published: July 2018

Background: There is no standard method for the surgical treatment of acromioclavicular (AC) joint separations. Current techniques have associated complications, including need for device removal, coracoid fracture, and inadequate reduction. Purpose: To evaluate the clinical outcomes of an internal splint technique without graft augmentation or rigid fixation to treat acute Rockwood type IV and V AC joint injuries. Study Design: Case series; Level of evidence, 4. Methods: A retrospective analysis was performed of 26 patients who underwent a novel internal splint fixation technique between 2011 and 2016. Patients had type IV (n = 2) and type V (n = 24) acute AC separations. The mean time to surgery was 13.7 days (range, 1-28 days). The surgical technique included an open approach with coracoclavicular suture and tape fixation and AC suture fixation. Range of motion, strength, and radiographs were evaluated after surgery. Patient follow-up included the DASH (Disabilities of the Arm, Shoulder and Hand) questionnaire at a mean 3.3 years postoperatively (range, 6 months–8.6 years). DASH questionnaires were obtained for all patients via email. Patients were also surveyed on cosmetic appearance and willingness to undergo the operation again. Results: All patients regained full strength and range of motion following surgery. All postoperative radiographs demonstrated well-maintained reduction of the AC joint. The mean DASH score was 3.4 at final follow-up, and 23 of 26 respondents were satisfied with their postoperative shoulder appearance. There were no reoperations, and all patients stated that they would have the operation again given the same circumstances. Conclusion: The results of this study demonstrate a reliable new technique for acute fixation of type IV or V AC joint injuries via an internal splint construct. This technique enables reduction in the coronal and sagittal planes without the need for graft augmentation or a rigid implant, allowing healing of the coracoclavicular and AC ligaments.
Ten-year outcome of patients with acute myeloid leukemia not treated with allogeneic transplantation in first complete remission
Authors: Vasu Sumithira , Kohlschmidt Jessica , Mrózek Krzysztof , Eisfeld Ann-Kathrin , Nicolet Deedra , Sterling Lisa J. , Becker Heiko , Metzeler Klaus H. , Papaioannou Dimitrios , Powell Bayard L. , Kolitz Jonathan E. , Moore Joseph O. , Baer Maria R. , Roboz Gail J. , Stone Richard M. , Byrd John C. , Carroll Andrew J. , Bloomfield Clara D. 
Published: July 2018

Key Points
Only 16.6% of patients aged <60 years and 2.4% aged ≥60 years treated with chemotherapy are disease-free at 10 years after diagnosis. Ten-year disease-free survivors were mostly diagnosed with core-binding factor AML with t(8;21) or inv(16), or had a normal karyotype.
Deserving poor and the desirability of a minimum wage
Authors: Blumkin Tomer , Danziger Leif 
Published: July 2018

AbstractThis paper provides a normative justification for the use of a minimum wage as a redistributive tool in a competitive labor market. We show that a government interested in improving the wellbeing of the deserving poor, while being less concerned with their undeserving counterparts, can use a minimum wage to enhance the efficiency of the tax-and-transfer system in attaining this goal.
Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders – CORRIGENDUM
Authors: Oviedo-Salcedo Tatiana , de Witte Lot , Kümpfel Tania , Kahn René S. , Falkai Peter , Eichhorn Peter , Luykx Jurjen , Hasan Alkomiet 
Published: July 2018

SummaryThis notice describes a correction to the above mentioned paper.
PTPα is required for laminin-2-induced Fyn–Akt signaling to drive oligodendrocyte differentiation
Authors: Ly Philip T. T. , Stewart Craig , Pallen Catherine J. 
Published: July 2018

ABSTRACT
Extrinsic signals that regulate oligodendrocyte maturation and subsequent myelination are essential for central nervous system development and regeneration. Deficiency in the extracellular factor laminin-2 (Lm2, comprising the α2β1γ1 chains), as occurs in congenital muscular dystrophy, can lead to impaired oligodendroglial development and aberrant myelination, but many aspects of Lm2-regulated oligodendroglial signaling and differentiation remain undefined. We show that receptor-like protein tyrosine phosphatase α (PTPα, also known as PTPRA) is essential for myelin basic protein expression and cell spreading during Lm2-induced oligodendrocyte differentiation. PTPα complexes with the Lm2 receptors α6β1 integrin and dystroglycan to transduce Fyn activation upon Lm2 engagement. In this way, PTPα mediates a subset of Lm2-induced signals required for differentiation, includeing mTOR-dependent Akt activation but not Erk1/2 activation. We identify N-myc downstream regulated gene-1 (NDRG1) as a PTPα-regulated molecule during oligodendrocyte differentiation, and distinguish Lm2 receptor-specific modes of Fyn–Akt-dependent and -independent NDRG1 phosphorylation. Altogether, this reveals an Lm2-regulated PTPα–Fyn–Akt signaling axis that is critical for key aspects of the gene expression and morphological changes that mark oligodendrocyte maturation.
Adaptive adhesion systems mediate glioma cell invasion in complex environments
Authors: Gritsenko Pavlo G. , Friedl Peter 
Published: July 2018

ABSTRACT
Diffuse brain invasion by glioma cells prevents effective surgical or molecular-targeted therapy and underlies a detrimental outcome. Migrating glioma cells are guided by complex anatomical brain structures but the exact mechanisms remain poorly defined. To identify adhesion receptor systems and matrix structures supporting glioma cell invasion into brain-like environments we used 2D and 3D organotypic invasion assays in combination with antibody-, peptide- and RNA-based interference. Combined interference with β1 and αV integrins abolished the migration of U-251 and E-98 glioma cells on reconstituted basement membrane; however, invasion into primary brain slices or 3D astrocyte-based scaffolds and migration on astrocyte-deposited matrix was only partly inhibited. Any residual invasion was supported by vascular structures, as well as laminin 511, a central constituent of basement membrane of brain blood vessels. Multi-targeted interference against β1, αV and α6 integrins expressed by U-251 and E-98 cells proved insufficient to achieve complete migration arrest. These data suggest that mechanocoupling by integrins is relatively resistant to antibody- or peptide-based targeting, and cooperates with additional, as yet unidentified adhesion systems in mediating glioma cell invasion in complex brain stroma.
Identifying communities from multiplex biological networks by randomized optimization of modularity
Authors: Didier Gilles , Valdeolivas Alberto , Baudot Anaïs 
Published: July 2018

The identification of communities, or modules, is a common operation in the analysis of large biological networks. The Disease Module Identification DREAM challenge established a framework to evaluate clustering approaches in a biomedical context, by testing the association of communities with GWAS-derived common trait and disease genes. We implemented here several extensions of the MolTi software that detects communities by optimizing multiplex (and monoplex) network modularity. In particular, MolTi now runs a randomized version of the Louvain algorithm, can consider edge and layer weights, and performs recursive clustering. On simulated networks, the randomization procedure clearly improves the detection of communities. On the DREAM challenge benchmark, the results strongly depend on the selected GWAS dataset and enrichment p-value threshold. However, the randomization procedure, as well as the consideration of weighted edges and layers generally increases the number of trait and disease community detected. The new version of MolTi and the scripts used for the DMI DREAM challenge are available at: https://github.com/gilles-didier/MolTi-DREAM.
A sulfur-free peptide mimic of surfactant protein B (B-YL) exhibits high in vitro and in vivo surface activities
Authors: Walther Frans J. , Gupta Monik , Gordon Larry M. , Waring Alan J. 
Published: July 2018

Background: Animal-derived surfactants containing surfactant proteins B (SP-B) and C (SP-C) are used to treat respiratory distress syndrome (RDS) in preterm infants. SP-B (79 residues) plays a pivotal role in lung function and the design of synthetic lung surfactant. Super Mini-B (SMB), a 41-residue peptide based on the N- and C-domains of SP-B covalently joined with a turn and two disulfides, folds as an α-helix hairpin mimicking the properties of these domains in SP-B. Here, we studied ‘B-YL’, a 41-residue SMB variant that has its four cysteine and two methionine residues replaced by tyrosine and leucine, respectively, to test whether these hydrophobic substitutions produce a surface-active, α-helix hairpin.Methods:Structure and function of B-YL and SMB in surfactant lipids were compared with CD and FTIR spectroscopy, and surface activity with captive bubble surfactometry and in lavaged, surfactant-deficient adult rabbits.Results:CD and FTIR spectroscopy of B-YL in surfactant lipids showed secondary structures compatible with peptide folding as an α-helix hairpin, similar to SMB in lipids. B-YL in surfactant lipids demonstrated excellentin vitrosurface activity and good oxygenation and dynamic compliance in lavaged, surfactant-deficient adult rabbits, suggesting that the four tyrosine substitutions are an effective replacement for the disulfide-reinforced helix-turn of SMB. Here, the B-YL fold may be stabilized by a core of clustered tyrosines linking the N- and C-helices through non-covalent interactions involving aromatic rings.Conclusions:‘Sulfur-free’ B-YL forms an amphipathic helix-hairpin in surfactant liposomes with high surface activity and is functionally similar to SMB and native SP-B. The removal of the cysteines makes B-YL more feasible to scale up production for clinical application. B-YL’s possible resistance against free oxygen radical damage to methionines by substitutions with leucine provides an extra edge over SMB in the treatment of respiratory failure in preterm infants with RDS.
O processo de empresarização e as mudanças nas relações de assalariamento e exploração
Authors: Tometich Patricia , Silva Rosimeri De Fátima Carvalho 
Published: July 2018

Neste ensaio questionamos o assalariamento como característica essencial de empresarização do mundo (SOLÉ, 2003; 2008; ABRAHAM, 2006), articulando a ideia de Mundo-Empresa (SOLÉ, 2008) com o ideario neoliberal, especialmente sua renovação (PUELLO-SOCARRÁS; 2008; 2013; LAVAL; DARDOT, 2013). Considerando que no ideário neoliberal o empreendedorismo é apontado como solução para geração de trabalho e renda, buscamos melhor compreender a expansão de empresa como o tipo hegemônico de organização. Apresentamos as modificações no mundo do trabalho e ilustramos nossa argumentação com a criação de duas categorías de empreendedores - independentes e dependentes, com inspiração no trabalho de Schumpeter (1982). O resultado do estudo é que na teoría sobre o proceso de empresarização o assalariamento deve ser substituído pela relação de exploração do trabalho.
Optimal Design of Return Policies
Authors: Tran Thanh , Gurnani Haresh , Desiraju Ramarao 
Published: July 2018

Quota-based and partial-refund return policies abound in practice between manufacturers and their resellers. While the literature has provided insights into the design of the partial-refund policy, little attention has been directed at the design of the quota-based return policy. Accordingly, this paper explores the relative preference of a quota-based policy vis-à-vis a partial-refund policy. We do this, first, in the context of risk-neutral channel partners to identify the strategic decisions of each party and the effect of demand uncertainty on the variation of their respective profits. Our results reveal that the manufacturer faces higher profit variation (between the different demand realizations) under the quota policy. The variance in profits for the reseller is, however, higher under the partial-refund policy. We explain the source of profit variations by comparing it across different channel structures (centralized and decentralized). Next, we formally extend the model to include a disutility associated with profit variation and show that when the manufacturer has a variation-induced disutility, the partial-refund contract should be used, as it is the dominating contract. Similarly, when the retailer has a variation-induced disutility, the quota contract should be used. This is consistent with the pattern of profit variations in the risk-neutral case where the manufacturer has lower variation with the partial-refund contract while the reseller has lower variation with the quota contract. Finally, our analysis also shows how the manufacturer may employ a combination policy to better manage its own profit variation while providing adequate overstocking protection for the reseller. The online appendix is available at https://doi.org/10.1287/mksc.2018.1094 .
The Term Structures of Coentropy in International Financial Markets
Authors: Chabi-Yo Fousseni , Colacito Riccardo 
Published: July 2018

We propose a new entropy-based correlation measure (coentropy) to evaluate the performance of international asset pricing models. Coentropy captures the codependence of two random variables beyond normality. We document that the coentropy of international stochastic discount factors (SDFs) can be decomposed into a series of entropy-based correlations of permanent and transitory components of the SDFs. We employ the cross section of G-10 countries to obtain model-free estimates of all the components of coentropy at various horizons and we show that the generalization of the long-run risk model featuring two predictable components of consumption growth rates, global disasters, and recursive preferences can account for the composition of codependence at all horizons. This paper was accepted by Tomasz Piskorski, finance.