bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ameliorative effect of rutecarpine supplementation against cisplatin‐induced nephrotoxicity in rats via inhibition of monocyte chemoattractant protein‐1, intercellular adhesion molecule‐1, high‐mobility group box 1, and nuclear factor kappa B
Authors: Zhang Dong , Jin Rui , Li Guoxing , Zhang CaiFeng , Zhou Yanhong 
Published: November 2024

AbstractCisplatin, the pioneering heavy metal compound, stands out as a potent drug for the treatment of various solid tumors. However, its clinical utility is hampered by notable toxicity and adverse effects, particularly nephrotoxicity. The potency of rutecarpine, a phytochemical, in mitigating cisplatin‐induced nephrotoxicity was assessed in the present study. In this experimental setup, healthy male Wistar rats were grouped into four and Group I rats served as the control group, receiving only vehicle control. Group II rats were subjected to cisplatin treatment alone, administered intraperitoneally at a dosage of 7 mg/kg body weight on the 19th, 20th, and 21st days. Group III and IV rats were orally administered with rutecarpine at doses of 10 and 20 mg/kg body weight, respectively, starting from Day 1 and continuing daily for 21 days. Additionally, they were injected intraperitoneally with cisplatin at the same dosage and schedule as Group II. Relative kidney weight and renal biochemical markers blood urea nitrogen, lactate dehydrogenase, serum urea, and creatinine were measured to assess rutecarpine inhibitory potency against cisplatin toxicity. Markers of oxidative damage and antioxidants levels were quantified in the ruteacarpine‐ and cisplatin‐treated rats. The study investigated the anti‐inflammatory property of rutecarpine in cisplatin‐induced nephrotoxicity by analyzing inflammatory cytokines. Renal tissue levels of monocyte chemoattractant protein‐1, intercellular adhesion molecule‐1, high‐mobility group box 1, and nuclear factor kappa B, key markers of nephrotoxicity, were quantified to assess rutecarpine's potential to mitigate cisplatin‐triggered damage. Histopathological examinations were performed to confirm the impact of rutecarpine against cisplatin‐induced nephrotoxicity. Treatment with rutecarpine notably reduced renal biochemical markers, prevented renal edema, and attenuated oxidative stress‐induced damage in cisplatin‐treated rats. Both inflammatory and nephrotoxicity markers showed significant decreases in rats treated with rutecarpine along with cisplatin. Histological analysis affirmed that rutecarpine pretreatment effectively prevented cisplatin‐induced nephrotoxicity. The study findings demonstrate that rutecarpine ameliorates cisplatin‐triggered nephrotoxicity through its antioxidant and anti‐inflammatory properties, suggesting that rutecarpine supplementation alongside cisplatin treatment could potentially reduce nephrotoxicity in cancer patients.
The development of supplemental multimedia learning modules and their impact on student learning in food biotechnology courses
Authors: Zhu Jiangyu , Yang Zhengfei , Yin Yongqi , Fang Weiming 
Published: November 2024

AbstractThe rapid growth of online education has created opportunities to integrate multimedia learning tools into complex scientific disciplines like food biotechnology. This study aimed to develop and evaluate supplementary online course modules on gene expression analysis, protein engineering tools, and fermentation genomics for undergraduate food biotechnology education. Based on cognitive load theory and multimedia learning principles, the modules incorporated focused visual media and interactive knowledge checks. The study involved 85 students in an introductory food microbiology course and 25 students in an upper‐level food biochemistry elective at a large public university. Module implementation included tracking student usage through learning management system analytics, collecting qualitative feedback, and assessing learning outcomes via exam performance. Results showed that 73%–76% of students voluntarily accessed the modules, with average engagement times of 5–8 min per module. Student feedback highlighted the modules' effectiveness in clarifying textbook content through replayable examples and real‐world scenarios. Comparison of exam scores revealed a 6%–10% improvement in performance on module‐related items compared to overall exam averages. Qualitative feedback indicated that students found the visual representations and interactive elements helpful for clarifying complex concepts. This study demonstrates the potential of well‐designed multimedia modules to support student learning in food biotechnology education, providing a model for expanding such resources in food science curricula.
Developing a Women's Heart Center With a Specialization in Coronary Microvascular and Vasomotor Dysfunction: If You Build It, They Will Come
Authors: Tapp Danielle N. , Ashokprabhu Namrita D. , Hamstra Michelle S. , Losekamp Melissa , Schmidt Christian , Palmer Cassady , Julie Gallatin N. P. , Tierney Darlene , Trenaman Tammy , Canoniero Mariana , Frizzell Jarrod , Henry Timothy D. , Quesada Odayme 
Published: November 2024

ABSTRACTBackgroundWomen's Heart Centers (WHC) are comprehensive, multidisciplinary care centers designed to close the existing gap in women's cardiovascular care. The WHC at The Christ Hospital Heart and Vascular Institute (TCH‐WHC) in Cincinnati, Ohio was established in October of 2020, and is a specialized coronary microvascular and vasomotor dysfunction (CMVD) program.MethodsThe TCH‐WHC focuses its efforts across five pillars: patient care, research, education, community outreach and advocacy, and grants and philanthropy. These areas, centered around providing specalized CMVD care and treatment have allowed for substantial growth.ResultsFrom October 2020‐December 2023, TCH‐WHC saw a total of 3219 patients, 42% of which were apart of the CMVD program. Since establishment, patient volume has consistently increased year over year.ConclusionThe CMVD program at TCH‐WHC is one of the fastest growing in the U. S. and is nationally recognized for specialized clinical care, diagnostics, and research. The goal of this review is to provide an overview of the TCH‐WHC structure that allows for the establishment and growth of a CMVD program and to outline core activities supporting the TCH‐WHC approach.
Breaking Activity‐Durability Inverse Relationship via Electrode Engineering by Utilizing β‐MnO2/RuO2 Heterostructures for Efficient Seawater Electrolysis
Authors: Bishwanathan Shashwat , Oberoi Simran Kaur , Gupta Prashant Kumar 
Published: November 2024

AbstractSignificant efforts are underway to enhance the efficiency of water electrolysis for sustainable hydrogen production. Approaches that were explored are the design of an efficient anode, engineering of electrolytes, and application of diffusion protective layer over the catalyst to protect it from corrosive reactions. Here we are exploring the engineering of electrode fabrication to enhance the efficacy of anode catalysts by ensuring that the materials are carefully selected. β‐MnO2 has been used to develop a cost‐effective method for electrode fabrication that establish a Schottky junction at heterostructure interface. This method transforms commercial RuO2, which is considered to be less active and stable, highly selective for chlorine oxidative reactions, into a highly active, stable, and OER‐selective in alkaline medium and surrogate seawater. With the help of thorough electrochemical techniques, we found that this engineering significantly improves the effective electrochemical surface area, and higher kinetics and conversion per unit site, profoundly affecting the charge transfer mechanism and optimizing the adsorption of OER intermediates, resulting in much‐increased mass activity. It is observed that the selectivity of the OER was enhanced due to the Lewis acid repercussions of β‐MnO2.
Strategies for improving the performance of practical Li‐CO2 battery
Authors: Zhu Kaige , Yin Shuai , Zhai Feiyue , Yan Dezhi , Tang Diyin , Xing Yalan , Zhang Shichao 
Published: November 2024

AbstractThe Li‐CO2 battery represented an enticing energy storage/output system characterized by its high‐specific energy capacity and simultaneously achieving CO2 fixation and conversion, which held significant promise in mitigating global warming and advancing toward carbon neutrality. Nonetheless, the current Li‐CO2 battery's practical capacity and energy efficiency lagged behind traditional lithium‐ion battery considerably, posing great challenges for practical applications and commercialization. This review comprehensively summarized recent advancements and prospective strategies aimed at enhancing the effectiveness of practical Li‐CO2 battery, encompassing insights into the cycling reaction mechanisms, anode electrode protection, key interface optimization, electrolyte design, and cathode catalyst innovations. Furthermore, insights into the prospects and key obstacles that lay ahead in advancing the Li‐CO2 battery toward practical applications were provided.
Traffic Prevention and Security Enhancement in VANET Using Deep Learning With Trusted Routing Aided Blockchain Technology
Authors: Swamynathan Cloudin , Shanmugam Revathy , Mohan Kumar Kanagasabapathy Pradeep , Subbiyan Balasubramani 
Published: November 2024

ABSTRACTVehicular ad hoc networks (VANETs) in portable broadband networks are a revolutionary concept with enormous potential for developing safe and efficient transportation systems. Because VANETs are open networks that require regular information sharing, it might be difficult to ensure the security of data delivered through VANETs as well as driver privacy. This paper proposes a blockchain technology that supports trusted routing and deep learning for traffic prevention and security enhancement in VANETs. Initially, the proposed Feature Attention‐based Extended Convolutional Capsule Network (FA_ECCN) model predicts the driver's behaviors such as normal, drowsy, distracted, fatigued, aggressive, and impaired. Next, the Binary Fire Hawks‐based Optimized Link State Routing Protocol (BFH_OLSRP) is used to route traffic after trust values have been assessed. Furthermore, Binary Fire Hawks Optimization (BFHO) determines the best routing path based on criteria such as link stability and node stability degree. Finally, blockchain storage is supported by the Interplanetary File System (IPFS) technology to improve the security of VANET data. Additionally, the validation process is established by using Delegated Practical Byzantine Fault Tolerance (DPBFT). As a result, the proposed study employs the blockchain system to securely send data to neighboring vehicles via trust‐based routing, thereby accurately predicting the driver's behavior. The proposed method achieves a better outcome in terms of latency, packet delivery ratio (PDR), overhead packets, throughputs, end‐to‐end delay, transmission overhead, and computational cost. According to simulation results and efficiency evaluation, the proposed approach outperforms existing approaches and enhances vehicle communication security in an effective manner.
Exploring the Relationship Between Dietary Phytochemical Index and Chemotherapy‐Related Symptoms: Insights From a Cross‐Sectional Study
Authors: Yüksel Barış , Dumlu Bilgin Gözde , Kavsara Hasan Kaan 
Published: November 2024

ABSTRACTPhytochemicals may confer substantial benefits in alleviating chemotherapy‐related symptoms. This cross‐sectional study aimed to determine the role of dietary phytochemicals on treatment‐related symptoms in patients receiving chemotherapy. Data including demographic variables, anthropometric measures such as weight and height, 3‐day food record, and Nightingale Symptom Assessment Scale (N‐SAS), a composite measure of patients' chemotherapy‐related symptoms, were gathered via face‐to‐face interviews. The dietary phytochemical index (DPI) was computed based on the patient's food records and presented by dividing into quartiles. The study included 152 participants with a mean age of 59.59 ± 13.19 years. The mean N‐SAS score was 2.16 ± 0.80. The average DPI score for the entire group was 24.66 ± 6.55, significantly higher in women (26.61 ± 6.06) than men (23.05 ± 6.54) (p = 0.001). As the DPI quartile values increased, there was a statistically significant decrease in N‐SAS scores (p = 0.002). A significantly negative correlation was found between the N‐SAS score and DPI, as well as all cancers (r = −0.364; p < 0.001). Additionally, a negative correlation was observed between the N‐SAS score and specific cancer types, comprising lung cancer (r = −0.513; p = 0.005), breast cancer (r = −0.612; p < 0.001), and gastrointestinal system (GIS) cancer (r = −0.329; p = 0.033). Increasing dietary phytochemicals in chemotherapy patients may help manage treatment‐related symptoms. Phytochemicals may confer substantial benefits in alleviating chemotherapy‐related symptoms. This cross‐sectional study aimed to determine the role of dietary phytochemicals on cancer‐related symptoms in patients receiving chemotherapy. A significantly negative correlation was found between N‐SAS score and DPI and all cancers (r = −0.364; p < 0.001) and different cancer types such as lung (r = −0.513; p = 0.005), breast (r = −0.612; p < 0.001), and GIS (r = −0.329; p = 0.033). As a result, increasing dietary phytochemicals in chemotherapy patients may help manage treatment‐related symptoms.
Recovery, Bioactivity, and Utilization of Bioactive Phenolic Compounds in Citrus Peel
Authors: Durmus Nihal , Gulsunoglu‐Konuskan Zehra , Kilic‐Akyilmaz Meral 
Published: November 2024

ABSTRACTCitrus peels are rich in bioactive phenolic compounds with various health effects including antioxidant, antiobesity, antiinflammatory, antihypertensive, antihypercholesterolemic, antimicrobial, antidiabetic, and anticarcinogenic activities. Both extractable and nonextractable phenolics are present in significant amounts in Citrus peel with diverse bioactivities. While extractable phenolics can be recovered from the fruit peels by conventional extraction methods, nonextractable phenolics remaining in the residues must be released from the cell matrix first by hydrolysis with acid, alkali, or enzymes. Novel processing technologies can help in improvement of extraction efficiency. Extreme process or medium conditions degrade phenolics and their bioactivity where encapsulation can be applied to improve their stability, solubility, and bioactivity. Citrus peel powder including ascorbic acid and dietary fiber besides phenolics or extracts therefrom can be used as functional food ingredients to extend shelf life and provide health benefits. In addition, phenolic extracts can be used as antioxidant and antimicrobial agents in active food packaging applications. Phenolic extracts have also a potential to be used as nutraceuticals and pharmaceuticals. In this review, phenolic compounds in different forms in Citrus peels, their recovery, bioactivity and possible applications for upcycling in the industry are presented.
Anatomy and Histology of Sensorimotor Connections Between the Facial and Trigeminal Nerve in the Buccinator Muscle
Authors: Mohanty Ahneesh J. , van Rooij Joep A. F. , Miseré Renée M. L. , Lataster Arno , Rozen Shai M. , van der Hulst René R. W. J. , Tuinder Stefania M. H. 
Published: November 2024

ABSTRACTBackgroundDespite indications of a close interaction between the trigeminal (CN V) and facial nerve (CN VII) within the buccinator muscle, a combination of anatomical dissection and histological analysis has not been reported.MethodsFive formalin‐fixed and fresh‐frozen hemifaces were dissected to reveal the buccal fat pad, the buccinator muscle, and anastomotic connections between CN V and CN VII within it. Samples were taken for histological processing and immunostaining.ResultsBranches of CN V and CN VII formed pronounced sensorimotor anastomotic connections in and surrounding the buccinator muscle. These findings were histologically evident with close intramuscular coupling of sensory and motor fibers. There was an evident but gradual shift from motor to sensory fibers in the interconnections when analyzing them from the side of CN V toward the side of CN VII and vice versa.ConclusionsThese results further elucidate connections between CN V and CN VII and their possible role in proprioception of the facial muscles.
Quandaries of Trying to Do Good—The Adequacy of the WHO FENSA Regulations
Authors: Benzian Habib , Beltrán‐Aguilar Eugenio , Niederman Richard , Caplan Arthur 
Published: November 2024

ABSTRACTThe World Health Organization's (WHO) Framework of Engagement with Non‐State Actors (FENSA), established in 2016, is designed to enhance transparency, impartiality, and conflict‐of‐interest safeguards by setting rigorous guidelines for WHO's interactions with private entities, particularly those in high‐risk industries such as tobacco, alcohol, and arms. This paper briefly reviews the implementation and impact of FENSA, observing that, despite these safeguards, its application in academic contexts poses specific challenges. Universities, often reliant on diverse funding sources, may find the rules restrictive and misaligned with independent funding needs. The creation of the WHO Foundation in 2020 further complicates this landscape by enabling engagements with previously restricted private sector entities through an “arm's length” model. The authors advocate for a reassessment of FENSA to resolve inconsistencies and support essential academic collaborations, while upholding WHO's commitment to ethical standards.
The Influence of Sanctions on Corporate Reporting Behaviour: International Evidence
Authors: Abweny Mohammad , Ahmed Rizwan , Benjasak Chonlakan , Nguyen Dung T. K. 
Published: November 2024

ABSTRACTThis study investigates the impact of sanctions on corporate reporting behaviour, encompassing both financial and sustainability reporting. Utilising comprehensive data from the Global Sanctions Database (GSDB), the study reveals an asymmetrical effect of sanctions on corporate reporting behaviours. Specifically, our findings reveal a negative relationship between sanctions and earnings management, suggesting a more conservative and transparent approach to financial reporting during sanction periods. However, the relationship between sanctions and the quality of sustainability reporting is significantly negative, indicating a decline in sustainability reporting quality during times of sanctions. Furthermore, the study provides evidence that EU sanctions have a stronger influence on both types of reporting compared to US sanctions. The results also break down the effects of each type of sanction on corporate reporting, indicating that financial and trade sanctions have a significant impact, while military and other types of sanctions do not show a significant effect. Drawing from signalling theory, corporate reports serve to signal stakeholders about a firm's behaviour and alleviate the information asymmetry between managers and other stakeholders. Consequently, our study contributes to signalling theory by illustrating that distinct signals are conveyed through different reports during uncertain periods, such as sanctions.
Biocompatibility and Antibacterial Potential of Tetrahedral Amorphous Carbon (ta‐C) Coatings on CoCrMo Alloy for Articulating Implant Surfaces
Authors: Fabisch Patrick , Voropai Vadym , Nieher Maren , Buchholz Adrian , Weissmantel Steffen , Lohmann Christoph H. , Bertrand Jessica , Döring Joachim 
Published: November 2024

ABSTRACTPremature implant failure, a critical concern in biomedical applications, is often attributed to poor biocompatibility and vulnerability to bacterial colonization. These issues are addressed by creating an endoprosthetic material with natural biocompatibility and antibacterial properties. In this in vitro study, the relaxed and unrelaxed tetrahedral amorphous carbon (ta‐C) coatings were examined, both fabricated by the improved patented Pulsed Laser Deposition (PLD) technology. The chemical composition, surface roughness, hardness, topography, and wettability were analyzed. The ta‐C surfaces were incubated by MM6 cells, E. coli and S. capitis bacteria for 24 h. PCR assessed the inflammatory response in MM6 cells, while fluorescence microscopy quantified adhering bacteria, and scanning electron microscopy examined local adhesion behavior. The results demonstrate comparable carbon phase composition, wettability properties, and hardness for both relaxed and unrelaxed ta‐C. However, relaxed ta‐C coating exhibited significantly fewer defects in terms of both quantity and quality, along with an antibacterial effect against E. coli. This suggests that the relaxed ta‐C coating could contribute to the development of an endoprosthesis, preventing adverse biological reactions and implant‐related infections, thus improving the longevity of the prosthesis.
Elastomeric and Conductive Nerve Conduits From Poly(Glycerol‐Sebacate)/Carbon Nanofibers (PGS/CNFs)
Authors: Topuz Bengisu , Gokcen Dincer , Aydin Halil Murat 
Published: November 2024

ABSTRACTMany patients suffer from peripheral nerve injury, which can impair their quality of life. Restoring nerve tissue is difficult due to the low ability of nerves to regenerate. Nerve conduits are designed to help peripheral nerve regeneration by providing a scaffold that can match the tissue characteristics, facilitate cellular activities, and be easily implanted. In order to provide a nerve conduit having scaffolding properties, conductance cytocompatibility, we have investigated the potential of channeled structures made of poly (glycerol‐sebacate) (PGS) elastomer containing carbon nanofibers (CNFs) in the regeneration of nerve tissue. The first step was to synthesize PGS elastomer and tune its properties to match the nerve tissue. Then, a carbon dioxide laser was used to create micro channels on the elastomer surface for guiding nerve cells. The PGS elastomer was blended with carbon nanofiber (CNF), which was functionalized to bond with the elastomer, to form a conductive structure. The constructs were investigated in terms of cell behavior using PC12 and S42 cell lines. A statistically significant increase in cell proliferation was observed in both cell lines. It was found that the cells began to grow along the canal in places. In terms of elasticity, conductance and cell response, these constructs may be a potential candidate for nerve tissue engineering.