bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe Plasmodium falciparum Malaria Treated With Investigational Artesunate in the United States
Authors: Shah Punit J. , Koshy Janice , Everett Nichelle , Attia Engie 
Published: June 2018

Purpose: We describe here the case of a 40-year-old Nigerian male with severe Plasmodium falciparum malaria successfully treated with investigational intravenous (IV) artesunate. Summary: A 40-year-old Nigerian male was admitted to the medical intensive care unit for the treatment of severe malaria. The patient presented with the classic malaria paroxysm and altered mental status and was in acute renal failure. A blood parasite, thick and thin smear was performed revealing positive ring forms on smear which are characteristic of Plasmodium falciparum, with an estimated parasitemia of 2%. Per the Centers for Disease Control and Prevention (CDC) guidelines, the recommended treatment for severe malaria is with IV quinidine, the only Food and Drug Administration (FDA)-approved medication available for the treatment of severe malaria in the United States. However, quinidine was not immediately available, including from surrounding hospitals. As a result, the infectious diseases physician and pharmacist decided to contact the CDC to initiate the process for obtaining IV artesunate, an investigational drug only available via a FDA-approved Investigational New Drug (IND) protocol. Artesunate was flown into Houston later that night, and this drug was administered successfully to the patient. Patient responded to treatment and was discharged from the hospital on day 4. Conclusion: A patient with severe falciparum malaria was successfully treated with investigational artesunate procured from the CDC.
Combined value of exhaled nitric oxide and blood eosinophils in chronic airway disease: the Copenhagen General Population Study
Authors: Çolak Yunus , Afzal Shoaib , Nordestgaard Børge G. , Marott Jacob L. , Lange Peter 
Published: June 2018

We investigated whether the combination of increased exhaled nitric oxide fraction (FeNO) level and blood eosinophil count had an additive value in chronic airway disease in the general population.We included 4677 individuals aged 20–100 years from the Copenhagen General Population Study. Based on pre- and post-bronchodilator spirometry, self-reported asthma and smoking history, participants were subdivided into healthy never-smokers (n=1649), healthy ever-smokers (n=1581), asthma (n=449), chronic obstructive pulmonary disease (COPD) (n=404), asthma–COPD overlap (ACO) (n=138) and nonspecific airflow limitation (n=456).Compared to individuals withFeNO<25 ppb and blood eosinophils <0.3×109 cells·L−1, age- and sex-adjusted odds ratios (95% CI) for wheezing were 1.54 (1.29–1.84) for individuals withFeNO≥25 ppb or blood eosinophils ≥0.3×109 cells·L−1and 2.14 (1.47–3.10) for individuals withFeNO≥25 ppb and blood eosinophils ≥0.3×109 cells·L−1. Corresponding odds ratios were 1.13 (0.91–1.41) and 1.83 (1.20–2.79) for sputum production, 1.54 (1.22–1.94) and 3.26 (2.16–4.94) for asthma, 1.03 (0.80–1.32) and 0.67 (0.36–1.27) for COPD and 1.32 (0.88–1.96) and 2.14 (1.05–4.36) for ACO. Among individuals reporting respiratory symptoms, predicting the type of chronic airway disease did not differ between the two biomarkers and did not improve by combining them.Combination ofFeNOand blood eosinophils may have an additive value in characterising chronic airway disease in the general population but still needs to be investigated further with regard to clinical application.
The impact of acute air pollution fluctuations on bronchiectasis pulmonary exacerbation: a case-crossover analysis
Authors: Goeminne Pieter C. , Cox Bianca , Finch Simon , Loebinger Michael R. , Bedi Pallavi , Hill Adam T. , Fardon Tom C. , de Hoogh Kees , Nawrot Tim S. , Chalmers James D. 
Published: June 2018

In bronchiectasis, exacerbations are believed to be triggered by infectious agents, but often no pathogen can be identified. We hypothesised that acute air pollution exposure may be associated with bronchiectasis exacerbations.We combined a case-crossover design with distributed lag models in an observational record linkage study. Patients were recruited from a specialist bronchiectasis clinic at Ninewells Hospital, Dundee, UK.We recruited 432 patients with clinically confirmed bronchiectasis, as diagnosed by high-resolution computed tomography. After excluding days with missing air pollution data, the final model for particles with a 50% cut-off aerodynamic diameter of 10 µm (PM10) was based on 6741 exacerbations from 430 patients and for nitrogen dioxide (NO2) it included 6248 exacerbations from 426 patients. For each 10 µg·m−³ increase in PM10and NO2, the risk of having an exacerbation that same day increased significantly by 4.5% (95% CI 0.9–8.3) and 3.2% (95% CI 0.7–5.8) respectively. The overall (lag zero to four) increase in risk of exacerbation for a 10 μg·m−3increase in air pollutant concentration was 11.2% (95% CI 6.0–16.8) for PM10and 4.7% (95% CI 0.1–9.5) for NO2. Subanalysis showed higher relative risks during spring (PM101.198 (95% CI 1.102–1.303), NO21.146 (95% CI 1.035–1.268)) and summer (PM102.142 (95% CI 1.785–2.570), NO21.352 (95% CI 1.140–1.602)) when outdoor air pollution exposure would be expected to be highest.In conclusion, acute air pollution fluctuations are associated with increased exacerbation risk in bronchiectasis.
Study Design and qPCR Data Analysis Guidelines for Reliable Circulating miRNA Biomarker Experiments: A Review
Authors: de Ronde Maurice W J , Ruijter Jan M , Moerland Perry D , Creemers Esther E , Pinto-Sietsma Sara-Joan 
Published: June 2018

Abstract

BACKGROUND
In the past decade, the search for circulating microRNA (miRNA) biomarkers has yielded numerous associations between miRNAs and different types of disease. However, many of these relations could not be replicated in subsequent studies under similar experimental conditions. Although this lack of replicability may be explained by the variation in experimental design and analysis methods, guidelines on the most appropriate design and analysis methods to study circulating miRNAs are scarce.

CONTENT
miRNA biomarker experiments generally consist of a discovery phase and a validation phase. In the discovery phase, typically hundreds of miRNAs are measured in parallel to identify candidate biomarkers. Because of the costs of such high-throughput experiments, the number of individuals included in those studies is often too small, which can easily lead to false positives and false negatives. In the validation phase, a small number of identified biomarker candidates are measured in a large cohort of cases and controls, generally by quantitative PCR (qPCR). Although qPCR is a sensitive method to measure miRNAs in the circulation, experimental design and qPCR data analysis remain challenging. Omitting some crucial steps in the design and analysis of the qPCR experiment or performing them incorrectly can cause serious biases, ultimately leading to false conclusions.

SUMMARY
In this review, we aim to expose and discuss the most common sources of interstudy variation in miRNA research from a methodological point of view and to provide guidelines on how to perform these steps correctly to increase replicability of studies on circulating miRNAs.
Curating Context: The Art Institute of Chicago’s 1945 Leopoldo Méndez Exhibition
Authors: Merfish Beth Matusoff 
Published: June 2018

Abstract
This article considers the exhibition of the work of leftist Mexican printmaker Leopoldo Méndez at the Art Institute of Chicago in 1945. Showing Méndez’s work in a manner that illuminated the artist’s communist loyalties could have been controversial in the postwar milieu, but the exhibition did not generate negative publicity. The professionals of the Art Institute, most notably Katherine Kuh and Carl Schniewind, perpetuated the invented populist legacy of printmaker José Guadalupe Posada to provide a folkloric and regional context for the work of Méndez. They thereby provided a reading that encouraged audiences to overlook the contemporary leftist political importance of Méndez’s work, and made the prints palatable to an audience that might otherwise have reacted strongly to the work of a communist Mexican artist at a time when the Good Neighbor Policy had come to an end and the Cold War had begun. This case study, the dynamics of which were repeated at parallel exhibitions at the Brooklyn Museum of Art, exemplifies the crucial challenge of the curatorial representations that have not problematized the context of the artistic narratives that they present.
Exhibiting the End: Curatorial Scenarios of Burial, Contagion and Extinction
Authors: Connolly Maeve 
Published: June 2018

Abstract
This article examines curatorial strategies used to contextualize, dramatize and narrativize events that unfold over timescales far exceeding that of the individual human lifespan, sometimes involving life forms that are posthuman or other-than-human. Three exhibition projects from 2015 will be analysed – A Breathcrystal curated by Mihnea Mircan, Riddle of the Burial Grounds curated by Tessa Giblin, and Disappearing Acts curated by Matt Packer and Arne Skaug Olsen – each of which explores situations of actual or potential disaster resulting from exposure to nonhuman organisms, nuclear waste or rising seas caused by climate change. Informed by T. J. Demos and Fredric Jameson’s theorizations of ‘negative utopianism’ in art theory and science fiction, I explore how these curatorial scenarios investigate the properties of human and nonhuman entities, whether encountered in the present or from vantage points of the distant past or future.
‘Savoy Truffle’: Love, lust and longing in a box of chocolates
Authors: Neill Lindsay , Hemmington Nigel 
Published: June 2018

Abstract
This article re-reads The Beatles’ song, ‘Savoy Truffle’, not as an ode to Eric Clapton’s rotting teeth and chocolate consumption, but rather as a thinly veiled rock music metaphor reflecting the triptych love relationship between its composer, George Harrison, his wife, Pattie Boyd, and her lover and later husband, Eric Clapton. Re-reading ‘Savoy Truffle’ provides a valuable insight into the intricacies of how popular rock music communicates constructs of love within metaphor and how The Beatles integrated multiple meanings into lyrics conveying love and its contention. Such multiplicity aids explanations exploring the band’s extraordinary popularity by providing a socio-temporal insight into an extra-ordinary time: the 1960s. In re-reading ‘Savoy Truffle’, this article contextualizes the multiplicity of love itself within an exploration of the passion within lust, the longing of desire and the satisfaction of having the desired object. The desired object was Pattie Boyd, who Harrison projected within a box of ‘Good News’ chocolates.
Are Zooxanthellae Really Sensitive? Response of Zooxanthellae Size Exposed to Several Pollutants
Authors: Ambariyanto Ambariyanto , Wijayanti Diah Permata , Munasik Munasik , Purnama Puji Eka , Hudatwi Mu’alimah , Ernawati Ni Made , Ko'ou Alferd Y. 
Published: June 2018

Pollution is one of the important issues faced by marine resources including zooxanthellae, which is known to be very sensitive to environmental changes. Some pollutants have been reported to have adverse effects on zooxanthellae, however, their sensitivity in regards to changes on cell size of these algae has not been widely explored. This study examined the effects of pollutants on the sensitivity of zooxanthellae through changes in size. Zooxanthellae were isolated from corals Porites lutea, Acropora aspera, and Montipora digitata collected from Panjang Island, Jepara, Indonesia. These algae were exposed to pollutants i.e. heavy metals (Cu, Cd, Pb) and nutrients (ammonium and phosphate) at concentrations of 5,10,15 ppb and 5,10,15 μM, respectively. Zooxanthellae size were measured five hours after pollutants exposure. The results showed that all treatments reduced the size of zooxanthellae. Algae isolated from P. lutea are the least affected by pollutants and the highest percentage cell size reduction was found in phosphate treatment. However, reduction on the size of algae were not statistically significant. These results indicate that in relation to reduction in the size, zooxanthellae are not sensitive to pollutants. Keywords: Zooxanthellae, pollutants, sensitivity, size reduction
Agreement in grammar and discourse: A research overview
Authors: Haig Geoffrey , Forker Diana 
Published: June 2018

AbstractAgreement is among the most widely-researched issues in theoretical linguistics. In this introduction, we critically review some of the key issues, focussing on typological approaches to agreement, the role of agreement in establishing and maintaining reference, and the emergence of agreement diachronically. We point to the interplay of semantic, pragmatic and syntactic factors in shaping the way agreement systems function, and emphasize the need for more usage-based research in understanding the impact of extra-syntactic factors. We also argue for greater attention to lesser-researched languages, particularly those where features other than person are central in agreement relations. Finally, we offer a short synopsis of the contributions to this issue.
Validity of the Handheld Doppler to Determine Lower-Limb Blood Flow Restriction Pressure for Exercise Protocols
Authors: Laurentino Gilberto C. , Loenneke Jeremy P. , Mouser James G. , Buckner Samuel L. , Counts Brittany R. , Dankel Scott J. , Jessee Matthew B. , Mattocks Kevin T. , Iared Wagner , Tavares Lucas D. , Teixeira Emerson L. , Tricoli Valmor 
Published: June 2018

Abstract
Laurentino, GC, Loenneke, JP, Mouser, JG, Buckner, SL, Counts, BR, Dankel, SJ, Jessee, MB, Mattocks, KT, Iared, W, Tavares, LD, Teixeira, EL, and Tricoli, V. Validity of the handheld Doppler to determine lower-limb blood flow restriction pressure for exercise protocols. J Strength Cond Res 34(9): 2693–2696, 2020—Handheld (HH) Doppler is frequently used for determining the arterial occlusion pressure during blood flow restriction exercises; however, it is unknown whether the blood flow is occluded when the auscultatory signal is no longer present. The purpose of this study was to assess the validity between the HH Doppler and the Doppler ultrasound (US) measurements for determining the arterial occlusion pressure in healthy men. Thirty-five participants underwent 2 arterial occlusion pressure measurements. In the first measure, a pressure cuff (17.5 cm wide) was placed at the most proximal region of the thigh and the pulse of posterior tibial artery was detected using an HH Doppler probe. The cuff was inflated until the auscultatory pulse was no longer detected. After 10 minutes of rest, the procedure was repeated with the Doppler US probe placed on the superficial femoral artery. The cuff was inflated up to the point at which the femoral arterial blood flow was interrupted. The point at which the auscultatory pulse and blood flow were no longer detected was deemed the arterial occlusion pressure. There were no significant differences in arterial occlusion pressure level between the HH Doppler and the Doppler US (133 [±18] vs. 135 [±17] mm Hg, p = 0.168). There was a significant correlation (r = 0.938, p = 0.168), reasonable agreement, and a total error of the estimate of 6.0 mm Hg between measurements. Arterial occlusion pressure level determined by the HH Doppler and the Doppler US was similar, providing evidence that the HH Doppler is a valid and practical method.
Influence of Sex on Current Methods of Adjusting Saddle Height in Indoor Cycling
Authors: Encarnación-Martínez Alberto , Ferrer-Roca Ventura , García-López Juan 
Published: June 2018

Abstract
Encarnación-Martínez, A, Ferrer-Roca, V, and García-López, J. Influence of sex on current methods of adjusting saddle height in indoor cycling. J Strength Cond Res 35(2): 519–526, 2021—The popularity of indoor cycling has increased in fitness centers, and therefore, proper bike fitting is important to avoid biomechanical-related injuries. However, no previous studies have compared the biomechanical kinematics of various existing protocols of saddle-height adjustment in indoor cycling. Furthermore, it was not clear if these protocols were appropriate for both men and women, as these equations were primarily obtained in male cyclists. Therefore, lower-limb joint kinematics were compared among 4 different protocols of saddle-height adjustment (1-Preferred, 2-Ferrer-Roca et al., 3-Lemond & Guimard, and 4-Static Goniometry) in 30 experienced indoor-cycling subjects (15 men and 15 women). Only 20–33% of the women had a knee extension while pedaling within the recommended range for each of the different protocols except for the preferred adjustment (73% were within). By contrast, all the protocols were moderately suitable for men (47–60% were within the recommended range). A multiple linear equation to estimate the recommended saddle height in both men and women (R
2 = 0.917, p = 0.001) was obtained from the following variables: inseam length, stature, foot length, and knee angle. The differences in the findings between men and women may be partially explained by differences in anatomical structures, as well as the male-based equations, which argues the need for future investigations in female cyclists.
Síndrome de Mirizzi
Authors: Cárdenas Quirós María Fabiola , Álvarez Chavez Ricardo 
Published: June 2018

El Síndrome de Mirizzi descrito en 1948 por el cirujano Pablo Luis Mirizzi, es una complicación poco frecuente que ocurre en aproximadamente 1% de los pacientes con colelitiasis.Consiste en la impactación de un lito biliar a nivel del conducto cístico o infundíbulo, que posteriormente produce una compresión del conducto hepático común, pudiendo ocasionar erosión y generar una fístula colecisto-coledociana.Clínicamente cursa con ictericia de origen obstructivo, y síntomas comunes de patología biliar. El diagnóstico preoperatorio sigue siendo de gran dificultad, diversos estudios han sido utilizados, entre los cuales se encuentran; la ecografía abdominal, la colangiopancreatografía endoscópica retrógrada, la colangiografía percutánea o la colangiorresonancia, según disponibilidad en los centros hospitalarios.El tratamiento sigue siendo quirúrgico, el abordaje operatorio, puede ser vía abierta o laparoscópica, en función del estadio y la experiencia del cirujano a cargo
El sujeto y la ética en Michel Foucault
Authors: Hernández Castro Gustavo 
Published: June 2018

El presente artículo tiene como objetivo analizar el pensamiento de Michel Foucault en torno al sujeto y la ética y su vínculo con la modernidad. Para establecer esa relación se analiza las categorías focultianas de saber, poder y gobernabilidad. El saber y el poder se organizan para someter la conducta de los sujetos; mientras la gobernabilidad debe ser analizada en dos vías; desde las prácticas de subjetivación, es decir, como un espacio en el cual se deben descubrir las significaciones originarias y en la cual se funda el sujeto; y por la desubjetivación mediante el cual, el sujeto ya no es el mismo, se desprende de sí, para convertirse en otro sujeto.
Estudio de sub-adultos de la cuenca del río San Francisco, provincia de Jujuy, Argentina (0-500 dc).
Authors: Ortiz María Gabriela , Paz Fernanda , Zenteno Brian , Zuñiga Soledad , Nieva Luis 
Published: June 2018

Se presenta el análisis de una muestra de individuos subadultos, exhumados en diferentes sitios de la región del valle del río San Francisco, con cronologías que abarcan ca. 2000 hasta los ca.1500 años antes delpresente. Se consideraron diferentes aspectos: estado de salud (especialmente patologías de origen metabólico), edad, marcadores epigenéticos, prácticas deformatorias y los contextos de inhumación o recuperación de los restos óseos. Se registraron escasos indicadores de estrés metabólico y solo un caso de lesiones traumáticas. También se observaron diversas prácticas culturales entre las que se incluyen deformación craneana, scalping-descarne peri y postmortem y exposición al fuego. Las formas de inhumación muestran una diversidad importante con entierros primarios en fosa, en urnas, y entierros secundarios. Se reflexiona sobre aspectos relacionados con las condiciones del ambiente donde vivieron, y las prácticas mortuorias como reflejo del rol social de los individuos subadultos.
Los procesos pedagógicos y su relación con la convivencia escolar
Authors: Duarte Duarte Jakeline , Jurado Juan Carlos 
Published: June 2018

Durante las décadas de los ochenta y noventa, la convivencia escolar en la ciudad de Medellín (Colombia) estuvo signada por una leyenda negra de barbarie, conflicto y agresividad entre los actores sociales de las instituciones educativas, y entre éstos y diversos actores urbanos. En contraposición, hoy en día y particularmente desde la alcaldía de Sergio Fajardo (2004-2007) y sus políticas dirigidas al mejoramiento de la calidad de la educación y la convivencia ciudadana, se ha considerado que la convivencia escolar está en uno de sus mejores momentos y que se han superado en"gran medida los viejos lastres de la violencia escolar y ciudadana.
YÜKSELMİŞ KAN EOZİNOFİL SAYISI CANLI VERİCİLİ KARACİĞER TRANSPLANTASYONU SONRASI GEÇ ORTAYA ÇIKAN AKUT REJEKSİYONUN (GOAR) TAHMİNİNDE ÖNEMLİ BİR BELİRTEÇ OLABİLİR Mİ?
Authors: ÖZBİLGİN Mücahit , EGELİ Tufan , ÜNEK Tarkan , AĞALAR Cihan , DEĞİRMENCİ Alikadir , ÖZKARDESLER Sevda , SAĞOL Özgül , ELLİDOKUZ Hülya , ASTARCIOĞLU İbrahim 
Published: June 2018

Amaç: ‘’Geç dönemde
ortaya çıkan akut rejeksiyon”(GOAR); canlı vericili karaciğer
nakillerinde(CVKN) 6.aydan sonraki rejeksiyonlardır. Tanısında; karaciğer
biyopsisi yerine daha az noninvaziv bir yöntem olan artmış kan Eozinofil sayısı
prediktif bir biomarker olarak kullanılabilir mi? Yöntem ve
Metod :
Araştırmamızda Dokuz Eylül Üniversitesi Tıp Fakültesi Genel Cerrahi Karaciğer
Nakli Biriminde Haziran 2000- 2017 yıllarında CVKN yapılan, 18 yaşından büyük
ve en az 6 ay sağkalımı olan hastalar çalışmaya dahil edilmiştir. GOAR gelişen
hastaların; demografik verileri, olması gereken greft ağırlığı/mevcut greft
ağırlığı oranı, soğuk iskemi süreleri, Child ve MELD skorları, immünossüpresif
rejimleri ve komorbiditeleri incelendi. GOAR’dan şüphelenilen olguların biyopsi
sonuçları ve biyopsi öncesi kan laboratuvar değerleri retrospektif olarak
tarandı. Bulgular: Çalışmada 240
Karaciğer naklinden 65(%27)’ine rejeksiyondan şüphelenilerek karaciğer biyopsisi
yapıldı. Olguların 28(%43)’inde GOAR
tespit edilirken, 37(%57)’sinde herhangi bir rejeksiyon bulgusuna rastlanmadı.
Biyopsiler Banff patoloji skorlamasına göre; 10(%35.7)’u hafif,13(%46.4)’ü orta
ve 5(%17.9)’i şiddetli rejeksiyonlardı. Ortalama izlem süresi 3056(184-4877)
gündü. Biyopsi yapılma zamanı ortalama postoperatif 660’ıncı(180-4354) gündü.
Yükselmiş kan Eozinofil değeri ile GOAR gelişimi arasında istatistiksel olarak
anlamlı bir ilişki saptandı (p&lt;0.001).

Sonuç: GOAR’un tanısında; karaciğer biyopsisine göre non-invaziv bir yöntem olan
yükselmiş kan Eozinofil değerleri prediktif bir belirteç olarak kullanılabilir.