bluuebunny/crossref_metadata_2025_split huggingface dataset:
Substance Use Research with Indigenous Communities: Exploring and Extending Foundational Principles of Community Psychology
Authors: Wendt Dennis C. , Hartmann William E. , Allen James , Burack Jacob A. , Charles Billy , D'Amico Elizabeth J. , Dell Colleen A. , Dickerson Daniel L. , Donovan Dennis M. , Gone Joseph P. , O'Connor Roisin M. , Radin Sandra M. , Rasmus Stacy M. , Venner Kamilla L. , Walls Melissa L. 
Published: July 2019

HighlightsIndigenous Peoples are concerned with previous experience of substance use research as disempowering.Community psychology principles may inform ethical community‐driven substance use research.We explore these principles through seven Indigenous substance use studies across the U.S. and Canada.Indigenous substance use research reflects, expands, and challenges community psychology principles.We discuss implications for Indigenous substance use research and community psychology.
Metal‐Catalyzed Dehydration of Primary Amides to Nitriles
Authors: Al‐Huniti Mohammed H. , Croatt Mitchell P. 
Published: July 2019

AbstractThe dehydration of primary amides to generate their respective nitriles is an isohypsic, or redox neutral, method to install a valuable functional group into a molecule. This process has been known for over 175 years, typically using highly reactive dehydrating agents and high temperatures. Recently, transition metal‐catalysis has enabled reactivity under milder reaction conditions, while also tolerating a wide range of functional groups. The removal of water from primary amides is still energetically uphill so a stoichiometric dehydrating agent is required. The dehydrating agents used in recent years can be rather benign, such as acetonitrile to generate acetamide. This Minireview focuses on metal‐catalyzed reactions to convert primary amides into nitriles and is organized based on the dehydrating agent.
Olfactory dysfunction persists after smoking cessation and signals increased cardiovascular risk
Authors: Siegel Jesse K. , Wroblewski Kristen E. , McClintock Martha K. , Pinto Jayant M. 
Published: July 2019

BackgroundOlfaction plays a critical role in health and function in older adults, and impaired sense of smell is a strong predictor of morbidity and mortality. Smoking cigarettes causes olfactory impairment, but the mechanism of damage and ability to recover after cessation are unknown. We investigated the relationship between time since quitting and olfactory dysfunction in order to elucidate the mechanism(s) by which smoking damages the olfactory system and to inform patient counseling.MethodsUsing longitudinal data from the National Social Life Health and Aging Project (n = 3528 older adults, including 1526 former smokers), we analyzed the association between odor identification performance and time since smoking cessation using multivariate ordinal logistic regression, adjusting for cognition and demographic variables. To test whether vascular disease plays a role, we also assessed the relationship between olfactory decline and incidence of heart attack and heart disease.ResultsFormer smokers who quit ≤15 years before testing had significantly impaired olfaction compared to never smokers (p = 0.04), but those who quit >15 years prior did not. Olfactory decline over 5 years showed modest evidence toward predicting increased incidence of heart attack or heart disease (p = 0.08).ConclusionOlfactory impairment in smokers persists 15 years after quitting, which is consistent with a vascular mechanism of impairment. Indeed, olfactory decline is a predictor of the development of cardiovascular disease. Taken together, these data suggest that olfactory loss may be a useful sign of underlying vascular pathology. Further investigation of olfactory loss as an early biomarker for cardiovascular disease is warranted.
Electrospinning polyethylene terephthalate/SiO2 nanofiber composite needle felt for enhanced filtration performance
Authors: Guo Yinghe , He Weidong , Liu Jingxian 
Published: July 2019

ABSTRACTIn this study, polyethylene terephthalate (PET) nanofiber membrane fabricated by electrospinning was newly applied to needle‐felt filters. The PET nanofiber membrane was electrospun in an optimal condition. Nanoparticles (SiO2) were used to reduce the fiber diameter. Polyphenylene sulfide needle felt (PPS NF), hot melt adhesive film, and PET nanofiber membrane were compounded into sandwich‐structured composite needle felt (PET/SiO2 NNF) by heat treatment. The dynamic filtration performance of PET/SiO2 NNF was compared with that of PPS NF and polytetrafluoroethylene‐coated needle felt (PTFE CNF). The results showed that PET/SiO2 NNF had a lower rate of increase of pressure drop and a higher dust removal rate. The completion cycle of PET/SiO2 NNF was longer than PPS NF and PTFE CNF, which extended its service life in real applications. The successful synthesis of PET/SiO2 NNF suggested a new method to synthesize an innovative high‐performance needle‐felt filter. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48282.
Electret characteristics of melt‐blown polylactic acid fabrics for air filtration application
Authors: Zhang Jianfeng , Chen Gangjin , Bhat Gajanan S. , Azari Homeira , Pen Huili 
Published: July 2019

ABSTRACTPolylactic acid (PLA) is a biodegradable and biocompatible polymer. Melt‐blown PLA electret fabrics have become attractive materials for air filter applications. Its filtration performance mainly depends on the electrostatic effect originating from electrets. How to improve their electret behavior and then to enhance their filtration efficiency has always been challenging. In this article, three melt‐blown PLA fabrics with different morphological or crystal structure are made from different process conditions or ingredient. The electrets are formed by means of corona charging technology. Their crystalline and morphological structure was analyzed, and filtration performance was measured. Their charge‐trapping feature was studied by thermal stimulating discharge technology. The results proved that the air filtration efficiency of three melt‐blown samples improved a lot when electrets were formed. Different crystalline structures of PLA fabrics will result in differences in their electret charge‐trapping feature. The PLA fabrics with semi‐crystalline characteristics display a regular charge‐trapped level distribution and amorphous structure hints the diversity of charge‐trapped levels. The deference in filtration resistance is mainly ascribed to the different fiber diameters and their distributions. More narrow distribution of fiber diameter leads to more compact fabrics and to higher filtration resistance. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48309.
Experimental evaluation of the hydrothermal stability of a silicone/zeolite composite foam for solar adsorption heating and cooling application
Authors: Calabrese Luigi , Brancato Vincenza , Frazzica Andrea 
Published: July 2019

ABSTRACTThis article evaluates the hydrothermal and mechanical stability of an adsorbent composite foam based on zeolite silicone for application in adsorption heat pump. The adsorption properties of the fresh composite adsorbents and their morphological features were already presented in previous papers. In the present work, hydrothermal aging of composite foams, at varying SAPO‐34 zeolite contents and under real operating conditions, was carried out in order to verify the stability of the synthetized material. This improvement of knowledge is a key point for the industrial application. This evaluation was successfully performed by means of adsorption measurements and compression test on aged samples, up to 1500 aging cycles. The adsorption properties of composite foams are effective and stable up to the maximum number of cycles of the aging process. Instead, from the mechanical point of view, composite foams with high content of zeolite, aged at long cycles, evidenced a slight stiffening that stimulates mechanical brittle behavior. The composite foam with 67% zeolite filler represents a threshold value beyond which the action of the hydrothermal aging implies a significant loss of flexibility and mechanical integrity, which limits its applicability under typical conditions. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48311.
Improvement of thermal stability and flame retardancy of polypolypropylene composite modified by ZnO and MoO3 nanowires
Authors: Guo Junhong , Liu Guotian , Guo Yongliang , Tian Li , Bao Xuemei , Zhang Xiujun , Yang Baoping , Cui Jinfeng 
Published: July 2019

ABSTRACTHerein, zinc oxide (ZnO) and molybdenum trioxide (MoO3) nanowires were prepared via the hydrothermal method. Then as‐prepared ZnO and MoO3 nanowires were fabricated to form ZnO/MoO3 compound nanostructure. ZnO/MoO3 compounds were incorporated into polypropylene (PP) with various loadings by melt blending. The D‐Optimal mixing design in Design‐Expert software was employed to study the effects of ZnO/MoO3 compound content on flame retardancy and mechanical properties of nanocomposites. Information on performance of thermal stability and flame retardancy of PP/ZnO/MoO3 nanocomposites was obtained through thermogravimetric analysis, cone calorimeter tests, and limiting oxygen index (LOI). The results reflected that the synthesized ZnO/MoO3 compound possessed high thermal stability and flame retardancy. The addition of 15 wt % ZnO nanowires and 13 wt % MoO3 nanowires increased LOI from 18.2 to 23.0%. Meanwhile, the tensile strength of the PP/ZnO/MoO3 nanocomposite decreased by 13.8% and the elongation at break of the PP nanocomposite increased by 20.4% compared with pure PP. Response surface analysis results also indicated that the loading of ZnO/MoO3 compound had an influence on the mechanical properties and flame retardancy of PP. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48312.
Switching of optical‐resolution selectivity through the Onsager's reaction field: Chiral recognition of dl‐amino acids by hydrophilic/hydrophobic chitosans
Authors: Sayama Daisuke , Hatanaka Masashi , Miyasaka Makoto 
Published: July 2019

ABSTRACTUnusual switching of optical‐resolution selectivity in chitosan resins is reported. While in hydrophilic chitosan resins, the l‐form of amino acids are selectively adsorbed, and in hydrophobic chitosan resins, the d‐form was preferred. We found that the adsorption selectivity of the amino acids in the optical‐resolution agents is controlled by the hydrophilicity/hydrophobicity or permittivity of the resins, through the Onsager's reaction field. This intriguing selectivity switching is supported by the polarized continuum model calculations. This method provides a promising strategy for switching of optical‐resolution preferences by controlling the permittivity of the resins. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48317.
New results on the robust stability of control systems with a generalized disturbance observer
Authors: Nie Zhuo‐Yun , Wang Qing‐Guo , She Jinhua , Liu Rui‐Juan , Guo Dong‐Sheng 
Published: July 2019

AbstractA generalized disturbance observer‐based (GDOB) control system and its robust stability are studied in this paper. One feature of this new GDOB scheme is that an inverse of the nominal plant in the standard DOB is no longer required. Thus, it is applicable to both minimum‐phase (MP) and non‐minimum‐phase (NMP) plants. New conditions for robust stability are derived for two cases: plants with no right half plane (RHP) zero and plants with no RHP pole, which are in a perfect dual form. The duality reveals that the robust stability for a plant with RHP zeros is met when the Q‐filter has a sufficiently large constant. This is fundamentally different from well‐known results for a MP plant. The stability conditions indicate that the robustness against large uncertainties not only can be achieved by a well‐selected Q‐filter, but also by the reduction of mismatch between a compensated plant and a desired model. The obtained stability results provide guidelines for the control system design. This is illustrated by three examples.
High aldehyde dehydrogenase activity at diagnosis predicts relapse in patients with t(8;21) acute myeloid leukemia
Authors: Yang Lu , Chen Wen‐Min , Dao Feng‐Ting , Zhang Yan‐Huan , Wang Ya‐Zhe , Chang Yan , Liu Yan‐Rong , Jiang Qian , Zhang Xiao‐Hui , Liu Kai‐Yan , Huang Xiao‐Jun , Qin Ya‐Zhen 
Published: July 2019

AbstractAcute myeloid leukemia (AML) with t(8;21) is a heterogeneous disease. Although the detection of minimal residual disease (MRD), which is indicated by RUNX1‐RUNX1T1 transcript levels, plays a key role in directing treatment, risk stratification needs to be improved, and other markers need to be assessed. A total of 66 t(8;21) AML patients were tested for aldehyde dehydrogenase (ALDH) activity by flow cytometry at diagnosis, and 52 patients were followed up for a median of 20 (1‐34) months. The median percentage of CD34+ALDH+, CD34+CD38‐ALDH+, and CD34+CD38+ALDH+ cells among nucleated cells were 0.028%, 0.012%, and 0.0070%, respectively. The CD34+ALDH+‐H, CD34+CD38‐ALDH+‐H, and CD34+CD38+ALDH+‐H statuses (the percentage of cells that were higher than the individual cutoffs) were all significantly associated with a lower 2‐year relapse‐free survival (RFS) rate in both the whole cohort and adult patients (P = .015, .016, and .049; P = .014, .018, and .032). Patients with < 3‐log reduction in the RUNX1‐RUNX1T1 transcript level after the second consolidation therapy (defined as MRD‐H) had a significantly lower 2‐year RFS rate than patients with ≥ 3‐log reduction (MRD‐L) (P = .017). The CD34+ALDH+ status at diagnosis was then combined with the MRD status. CD34+ALDH+‐L/MRD‐H patients had similar 2‐year RFS rates to both CD34+ALDH+‐L/MRD‐L and CD34+ALDH+‐H/MRD‐L patients (P = .50 and 1.0); and CD34+ALDH+‐H/MRD‐H patients had significantly lower 2‐year RFS rate compared with CD34+ALDH+‐L and/or MRD‐L patients (P < .0001). Multivariate analysis showed that CD34+ALDH+‐H/MRD‐H was an independent adverse prognostic factor for relapse. In conclusion, ALDH status at diagnosis may improve MRD‐based risk stratification in t(8;21) AML, and concurrent high levels of CD34+ALDH+ at diagnosis and MRD predict relapse.
Typical angina in a patient with Takayasu arteritis
Authors: Hanson Christopher A. , Ragosta Michael 
Published: July 2019

AbstractTakayasu arteritis (TA) is a well‐reported form of large‐vessel vasculitis that primarily affects the aorta and its major branches. Cardiac manifestations of TA have been reported and can include typical angina secondary to coronary artery involvement; however, typical angina in the setting normal coronary arteries is uncommon. We describe a case of typical angina in a patient with TA with normal coronary arteries secondary to diastolic hypotension, in the absence of significant aortic regurgitation, likely from poor aortic distensibility and elevated left ventricular end‐diastolic pressure.
C‐terminal Cysteines of CueR Act as Auxiliary Metal Site Ligands upon HgII Binding—A Mechanism To Prevent Transcriptional Activation by Divalent Metal Ions?
Authors: Balogh Ria K. , Gyurcsik Béla , Hunyadi‐Gulyás Éva , Schell Juliana , Thulstrup Peter W. , Hemmingsen Lars , Jancsó Attila 
Published: July 2019

AbstractIntracellular CuI is controlled by the transcriptional regulator CueR, which effectively discriminates between monovalent and divalent metal ions. It is intriguing that HgII does not activate transcription, as bis‐thiolate metal sites exhibit high affinity for HgII. Here the binding of HgII to CueR and a truncated variant, ΔC7‐CueR, without the last 7 amino acids at the C‐terminus including a conserved CCHH motif is explored. ESI‐MS demonstrates that up to two HgII bind to CueR, while ΔC7‐CueR accommodates only one HgII. 199mHg PAC and UV absorption spectroscopy indicate HgS2 structure at both the functional and the CCHH metal site. However, at sub‐equimolar concentrations of HgII at pH 8.0, the metal binding site displays an equilibrium between HgS2 and HgS3, involving cysteines from both sites. We hypothesize that the C‐terminal CCHH motif provides auxiliary ligands that coordinate to HgII and thereby prevents activation of transcription.
Chalcogen OCF3 Isosteres Modulate Drug Properties without Introducing Inherent Liabilities
Authors: Ghiazza Clément , Billard Thierry , Dickson Callum , Tlili Anis , Gampe Christian M. 
Published: July 2019

AbstractThe synthesis of SCF3 as well as SeCF3 isosteres of two OCF3‐containing drugs was achieved through visible light and copper‐catalyzed processes. Herein, we show that chalcogen replacement modulates physicochemical and ADME properties without introducing intrinsic liabilities. The SCF3 and SeCF3 groups are more lipophilic than their oxygen counterpart; however, microsomal stability is unchanged, indicating that these molecular changes may be beneficial for in vivo half‐life. Enabled by modern synthetic methods, we present the chalcogen‐CF3 groups as potential key players for future fluorinated pharmaceuticals.
Compensatory changes in degenerating spinal motoneurons sustain functional sparing in the SOD1‐G93A mouse model of amyotrophic lateral sclerosis
Authors: Giusto Elena , Codrich Marta , de Leo Gioacchino , Francardo Veronica , Coradazzi Marino , Parenti Rosalba , Gulisano Massimo , Vicario Nunzio , Gulino Rosario , Leanza Giampiero 
Published: July 2019

AbstractPlastic changes have been reported in the SOD1‐G93A mouse model of amyotrophic lateral sclerosis, a disorder characterized by progressive motoneuronal loss; however, whether these changes related with the onset and development of motor impairments is still unclear. Here, the functional and anatomical changes taking place in SOD1‐G93A mice and their time course were investigated during ongoing motoneuronal degeneration. Starting from about 4 postnatal weeks, SOD1‐G93A and wild‐type (WT) mice were evaluated in the rotarod test, to be sacrificed at about 12–13 or 19 weeks of age, and their lumbar spinal cords were processed for histo‐ and immunohistochemistry. Compared to age‐matched WT controls, 12 weeks‐old SOD1‐G93A mice exhibited relatively mild or no motor impairments in the rotarod test, in spite of a dramatic (≈60%, as estimated by stereology) loss of choline acetyl‐transferase (ChAT)‐immunoreactive motoneurons which remained virtually unchanged in SOD1‐G93A mice surviving up to 19 weeks. Notably, the functional sparing in SOD1‐G93A mice at 12 weeks was paralleled by a marked ≈50% increase in motoneuron volume and a near‐normal density of acetylcholinesterase‐positive process arborization, which was significantly increased when analyzed as ratio to the decreased number of ChAT‐positive motoneurons. By contrast, at 19 weeks, when motor deficits had become dramatically evident, both measures were found reverted to about 50–60% of control values. Thus, at specific stages during the progression of the disease, robust compensatory events take place in surviving motoneurons of SOD1‐G93A mice, which sustain motor performance, and whose full understanding may highlight a valuable therapeutic opportunity window.
Sustainable development and the rating effects: A strategic categorization approach
Authors: Zeng Guangtao , Xu Yuehua 
Published: July 2019

AbstractWith the increasing call for sustainable development, rating agencies of corporate sustainability performance (CSP) have got a good momentum of development all over the world. Different from past studies that utilize stakeholder theory or information economics in explaining rating effects, this study takes a strategic categorization approach to investigate firm responses to CSP ratings of a newly emerging rating agency. Using a sample of listed firms in Japan, our study finds that compared with firms with moderate CSP rating scores, firms with high or low rating scores are more likely to increase their corporate philanthropic contributions, and such an effect is strengthened when the firms have higher levels of foreign ownership. This study contributes to the literature by enriching our understanding of how the rating of a newly emerging rating agency shapes firms' sustainable activities.
Standardization of Flow Cytometric Immunophenotyping for Hematological Malignancies: The FranceFlow Group Experience
Authors: Solly Françoise , Angelot‐Delettre Fanny , Ticchioni Michel , Geneviève Franck , Rambaud Hubert , Baseggio Lucile , Plesa Adriana , Debliquis Agathe , Garnache‐Ottou Francine , Roggy Anne , Campos Lydia , Aanei Carmen , Rosenthal‐Allieri Alessandra , Georget Marie‐Thérèse , Lachot Sébastien , Jacob Marie‐Christine , Robillard Nelly , Wuilleme Soraya , Andre‐Kerneis Elisabeth , Cornet Edouard , Salaun Véronique , Bennami Hind , Lhoumeau Anne‐Catherine , Arnoulet Christine , Jacqmin Hugues , Neyman Nicolas , Latger‐Cannard Véronique , Massin Fredéric , Lainey Elodie , Le Garff‐Tavernier Magali , Costopoulos Myrto , Roussel Mickael , Mayeur‐Rousse Caroline , Eischen Alice , Raggeneau Victoria , Derrieux Coralie , Maurer Maxime , Asnafi Vahid , Trinquand Amélie , Brouzes Chantal , Lhermitte Ludovic 
Published: July 2019

AbstractFlow cytometry is broadly used for the identification, characterization, and monitoring of hematological malignancies. However, the use of clinical flow cytometry is restricted by its lack of reproducibility across multiple centers. Since 2006, the EuroFlow consortium has been developing a standardized procedure detailing the whole process from instrument settings to data analysis. The FranceFlow group was created in 2010 with the intention to educate participating centers in France about the standardized instrument setting protocol (SOP) developed by the EuroFlow consortium and to organise several rounds of quality controls (QCs) in order to evaluate the feasibility of its application and its results. Here, we report the 5 year experience of the FranceFlow group and the results of the seven QCs of 23 instruments, involving up to 19 centers, in France and in Belgium. The FranceFlow group demonstrates that both the distribution and applicability of the SOP have been successful. Intercenter reproducibility was evaluated using both normal and pathological blood samples. Coefficients of variation (CVs) across the centers were <7% for the percentages of cell subsets and <30% for the median fluorescence intensities (MFIs) of the markers tested. Intracenter reproducibility provided similar results with CVs of <3% for the percentages of the majority of cell subsets, and CVs of <20% for the MFI values for the majority of markers. Altogether, the FranceFlow group show that the 19 participating labs might be considered as one unique laboratory with 23 identical flow cytometers able to reproduce identical results. Therefore, SOP significantly improves reproducibility of clinical flow in hematology and opens new avenues by providing a robust companion diagnostic tool for clinical trials in hematology. © 2019 International Society for Advancement of Cytometry