bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRR34‐AS1 overexpression promotes protection of propofol pretreatment against ischemia/reperfusion injury in a mouse model after total knee arthroplasty via blockade of the JAK1‐dependent JAK‐STAT signaling pathway
Authors: Fang Hua , Zhang Fang‐Xiang , Li Hua‐Feng , Yang Miao , Liao Ren , Wang Ru‐Rong , Wang Quan‐Yun , Zheng Peng‐Cheng , Zhang Jian‐Ping 
Published: September 2019

AbstractLong noncoding RNAs have been documented to be protective against ischemia/reperfusion (I/R) injury. However, few research works have focused on the protective effects of PRR34‐AS1 on I/R injury after total knee arthroplasty (TKA). The objective of the present study was to investigate the possible effect of PRR34‐AS1 on I/R injury after TKA. A mouse model with I/R injury after TKA was established. The interaction between PRR34‐AS1 and Janus kinase 1 (JAK1) was examined and thoroughly investigated. Next, the effects of PRR34‐AS1 on the expression of apoptosis‐related proteins, JAS‐signal transducer and activator of transcription (STAT) signaling pathways, and inflammation‐related genes, chondrocyte proliferation, and apoptosis were analyzed after gain‐ and loss‐of‐function experiments. Attenuated symptoms were observed in mice pretreated with propofol, which was evidenced by decreased positive expression rate of JAK1 protein and superoxide dismutase content along with increased malondialdehyde content and IL‐10 levels. PRR34‐AS1 was poorly expressed in mice with I/R injury after TKA. JAK1 was a target of PRR34‐AS1. Upregulated PRR34‐AS1 diminished expression of JAK1, STAT1, JAK2, and STAT3 as well as cell apoptosis, while enhancing cell proliferation in vitro. Furthermore, JAK1 silencing could reverse the suppressed cell proliferation and enhanced cell apoptosis of chondrocytes imposed by silencing PRR34‐AS1. Upregulation of PRR34‐AS1 can potentially relieve I/R injury after TKA in mice pretreated with propofol through inhibition of the JAS‐STAT signaling pathway by targeting JAK1.
Decoding communication patterns of the innate immune system by quantitative proteomics
Authors: Sukumaran Arjun , Coish Jeremia M , Yeung Jason , Muselius Benjamin , Gadjeva Mihaela , MacNeil Adam J , Geddes-McAlister Jennifer 
Published: September 2019

Abstract
The innate immune system is a collective network of cell types involved in cell recruitment and activation using a robust and refined communication system. Engagement of receptor-mediated intracellular signaling initiates communication cascades by conveying information about the host cell status to surrounding cells for surveillance and protection. Comprehensive profiling of innate immune cells is challenging due to low cell numbers, high dynamic range of the cellular proteome, low abundance of secreted proteins, and the release of degradative enzymes (e.g., proteases). However, recent advances in mass spectrometry-based proteomics provides the capability to overcome these limitations through profiling the dynamics of cellular processes, signaling cascades, post-translational modifications, and interaction networks. Moreover, integration of technologies and molecular datasets provide a holistic view of a complex and intricate network of communications underscoring host defense and tissue homeostasis mechanisms. In this Review, we explore the diverse applications of mass spectrometry-based proteomics in innate immunity to define communication patterns of the innate immune cells during health and disease. We also provide a technical overview of mass spectrometry-based proteomic workflows, with a focus on bottom-up approaches, and we present the emerging role of proteomics in immune-based drug discovery while providing a perspective on new applications in the future.
The Kaufman Domains of Creativity Scale: Turkish Validation and Relationship to Academic Major
Authors: Kandemir Mehmet Ali , Kaufman James C. 
Published: September 2019

AbstractOne common self‐assessment of creativity is the Kaufman Domains of Creativity Scale (K‐DOCS). This article provides support for a Turkish translation of the instrument, offering exploratory and confirmatory factor analysis to determine whether the factors were consistent across cultures. The participants consisted of two groups. The first group consisted of 1,260 undergraduate students (912 females, 348 males) at a public university in Turkey and was utilized for the principal axis factoring analysis. Horn's parallel analysis, a robust statistical technique, was employed to determine the number of factors to be extracted from a scale. The second group consisted of 1,215 participants (885 females and 330 males) who were utilized for confirmatory factor analysis. Results supported a nine‐factor solution as a better fit for this sample than the five‐solution originally used by Kaufman. Of the original five factors, four factors were divided into two sub‐factors, which were distinct although moderately correlated. Finally, we determined the relationship between K‐DOCS factors and college major. We also found good evidence for the construct, discriminant, and convergent validity of the scale. Relationships between K‐DOCS factors and college major were largely consistent with predictions, providing additional evidence for the construct validity of the scale.
Morphological and Apparent‐Level Stiffness Variations Between Normal and Osteoarthritic Bone in the Humeral Head
Authors: Knowles Nikolas K. , Kusins Jonathan , Columbus Melanie P. , Athwal George S. , Ferreira Louis M. 
Published: September 2019

ABSTRACTOsteoarthritis (OA) is characterized by morphological changes that alter bone structure and mechanical properties. This study compared bone morphometric parameters and apparent modulus between humeral heads excised from end‐stage OA patients undergoing total shoulder arthroplasty (n = 28) and non‐pathologic normal cadavers (n = 28). Morphometric parameters were determined in central cores, with regional variations compared in four medial to lateral regions. Linear regression compared apparent modulus, morphometric parameters, and age. Micro finite element models estimated trabecular apparent modulus and derived density–modulus relationships. Significant differences were found for bone volume fraction (p < 0.001) and trabecular thickness (p < 0.001) in the most medial regions. No significant differences occurred between morphometric parameters and apparent modulus or age, except in slope between groups for apparent modulus versus trabecular number (p = 0.021), and in intercept for trabecular thickness versus age (p = 0.040). Significant differences occurred in both slope and intercept between density–modulus regression fits for each group (p ≤ 0.001). The normal group showed high correlations in the power‐fit (r2 = 0.87), with a lower correlation (r2 = 0.61) and a more linear relationship, in the OA group. This study suggests that alterations in structure and apparent modulus persist mainly in subchondral regions of end‐stage OA bone. As such, if pathologic regions are removed during joint replacement, computational models that utilize modeling parameters from non‐pathologic normal bone may be applied to end‐stage OA bone. An improved understanding of humeral trabecular bone variations has potential to improve the surgical management of end‐stage OA patients. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:503–509, 2020
Efficacy validation of a lymphatic drainage device for lymphedema drainage in a rat model
Authors: Cheng Ming‐Huei , Yang Chin Yu , Tee Richard , Hong Yu‐Ting , Lu Chih‐Cheng 
Published: September 2019

AbstractBackgroundVascularized lymph node transfer (VLNT) is an effective surgery for extremity lymphedema. This study evaluated a lymphatic drainage device (LDD) for the drainage of accumulated fluid into the venous system.MethodsMicropore filtering membranes with pore sizes of 5, 0.65, and 0.22 μm polyvinylidene difluoride, and 0.8 μm Nylon Net Filter were evaluated to determine the in vitro efficiency of drainage flow of an LDD. The two superior membranes were further used for the evaluation of the inflow and outflow of the LDD in vivo using 5% albumin.ResultsAt 5 minutes, the volumes drained with 5, 0.65, and 0.22 μm polyvinylidene difluoride and 0.8 μm nylon membranes were 15.2, 2.77, 2.37, and 0.59 mL, respectively (P < .01). At 10 minutes, the collected volumes of 5 and 0.65 μm polyvinylidene difluoride were 1788 and 1051 μL (P = .3). The indocyanine green fluorescence was detected at 50 seconds for the 5 μm polyvinylidene difluoride membrane but not for the 0.65 μm membrane.ConclusionsThe study successfully demonstrated the proof‐of‐concept of the LDD prototype that mimicked VLNT with drainage of 5% albumin into the venous system in a rat model.
Does consumer‐firm affiliation matter? The impact of social distance on consumers’ moral judgments
Authors: Lo Carolyn J. , Tsarenko Yelena , Tojib Dewi 
Published: September 2019

AbstractWhen the leader of a firm commits a professional transgression, how would customers’ judgments of the transgressor's professional performance and immorality differ from those of noncustomers’? This research answers this question by investigating factors that explain the discrepancy in moral judgments between noncustomers and customers affiliated with the firm of a transgressing leader. Drawing on construal level theory, our two experimental studies consistently demonstrate that relative to high social distance (i.e., noncustomers), low social distance (i.e., customers) leads to more positive judgments of the transgressor's professional performance, but differences in the social distance do not directly lead to disparities in judgments of immorality. Social distance, however, affects both performance and immorality judgments when mediating mechanisms (conscious and nonconscious moral reasoning) are accounted for, such that low social distance indirectly influences customers to be more lenient in not only their performance judgments but also their immorality judgments. This research contributes to the topic of morality that permeates the current discourse on ethical business transgressions and, in particular, to an understanding of specific mechanisms that guide consumers’ moral judgments.
Antiapoptotic properties of MALT1 protease are associated with redox homeostasis in ABC‐DLBCL cells
Authors: Zhu Leqing , Tang Fen , Lei Zhiwei , Guo Chengbin , Song Yueqi , Huang Junqing , Xia Xichun 
Published: September 2019

AbstractMucosa‐associated lymphoid tissue lymphoma translocation protein‐1 (MALT1) protease presents crucial antiapoptotic properties in activated B cell‐like diffuse large B‐cell lymphoma (ABC‐DLBCL); however, the mechanism is unclear. Here, we reported that inhibition of MALT1 protease in ABC‐DLBCL cells led to cell apoptosis, along with elevated mitochondrial reactive oxygen species production and a reduced oxygen consumption rate. These alterations induced by MALT1 protease inhibition were associated with reduced expression of glutaminase (GLS1) and glutathione levels. We further show that MALT1 protease was required for the activation and nuclear translocation of c‐Jun, which functions as a transcription factor of the GLS1 gene by binding directly to its promoter region. Taken together, MALT1 protease maintained mitochondrial redox homeostasis and mitochondrial bioenergetics through the MALT1‐c‐Jun‐GLS1‐coupled metabolic pathway to defend against apoptosis in ABC‐DLBCL cells, which raises exciting possibilities regarding targeting of the MALT1‐c‐Jun‐GLS1 axis as a potential therapeutic strategy against ABC‐DLBCL.
Tracheostomy manipulations: Impact on tracheostomy safety
Authors: Espinel Alexandra G , Scriven Kelly , Shah Rahul K 
Published: September 2019

AbstractImportanceTracheotomy is one of the riskiest procedures for composite morbidity within pediatric otolaryngology. During the postoperative period, each time the tracheostomy tube is manipulated, there is opportunity for morbidity (e.g. a patient is vulnerable to accidental decannulation and airway loss).ObjectiveTo identify areas of improvement in caring for “fresh tracheostomy” patients by determining the number of times a tracheostomy tube is manipulated from placement until discharge. The hypothesis is that the more a tracheostomy is manipulated, the higher probability of morbidity.MethodsA quality improvement initiative was conducted to map the care of patients who underwent tracheostomy placement over 12 months. Tracheostomy care and manipulation by all providers were reviewed. Complications, wound care, and respiratory treatments were also evaluated.ResultsPatients were hospitalized for an average of 39 days (7–140) following tracheostomy. The first tracheostomy tube change occurred on average 6 days (5–10) following placement. Tracheostomy tubes were manipulated an average of 6 (2.5–11.9) times a day to amount to 216 (51–1091) times between placement and discharge. Bedside nurses and respiratory therapists were responsible for 95% of these actions; physicians accounted for 4%. There were 6 tracheostomy related complications. Three were accidental decannulations resulting in cardiopulmonary arrest. One of these caused long term patient morbidity. Patients with more than 4 manipulations per day during the 2 weeks following tracheostomy tube placement, were more likely to have a tracheostomy related complication than those with less than 4 (OR: 12.5; 95% CI: 1.2–130.6; P = 0.0349).InterpretationWhile uncommon, complications related to tracheostomy can have serious long term effects and at best prolongs length of stay for patients. Reducing the number of tracheostomy manipulations may provide safer postoperative care ultimately reducing morbidity and potentially mortality; children on average have 6 tracheotomy manipulations/day with only 2% being by the physician.
Quality of life in children following nasal septal surgery: A review of its outcome
Authors: Saniasiaya Jeyasakthy , Abdullah Baharudin 
Published: September 2019

AbstractNasal septal surgery among children remains controversial because of its adverse effect on craniofacial development. Recent studies, however, have demonstrated that early nasal septal correction prevents the midfacial and nasal growth deformity that is the inevitable consequence of nasal septal abnormality. Nasal septal surgery in children has been reported to lead to significant improvement in quality of life. We reviewed the existing literature to evaluate the outcomes of pediatric nasal septal surgery.
The use of biologics in children with allergic rhinitis and chronic rhinosinusitis: Current updates
Authors: Shinee Tan , Sutikno Budi , Abdullah Baharudin 
Published: September 2019

AbstractThe therapeutic goals of the treatment of allergic rhinitis (AR) and chronic rhinosinusitis (CRS) are symptom relief, avoiding complications, and improving quality of life. In the treatment of AR and CRS, several limitations of currently prescribed medicines have been identified. Antihistamine administration (both oral and topical) together with intranasal corticosteroids bring relief to the majority of patients, but their dependency on the medications and a necessity to maintain strict compliance with regular medication regimes pose a challenge. Immunotherapeutic agents are an option in some patients, but polysensitized patients, the risk of anaphylaxis, and the need for daily administration for years are limiting it from becoming the main therapy modality. Immunotherapy in any form requires commitment by the patient, which renders adherence and compliance issues particularly relevant. The procedure involved are generally time‐consuming and entail an associated risk of severe adverse reactions. The use of biologics could overcome the limitations of other therapeutic modalities. They could be used as a monotherapy or combined with pre‐existing medications. The benefits of targeted therapy include less adverse effects and optimal efficacy. The aim of the present review was to investigate the collective literature to date pertaining to the role of biologics in managing children with AR and CRS.
Using acoustic metrics to characterize underwater acoustic biodiversity in the Southern Ocean
Authors: Roca Irene T. , Van Opzeeland Ilse 
Published: September 2019

AbstractAcoustic metrics (AM) assist our interpretation of acoustic environments by aggregating a complex signal into a unique number. Numerous AM have been developed for terrestrial ecosystems, with applications ranging from rapid biodiversity assessments to characterizing habitat quality. However, there has been comparatively little research aimed at understanding how these metrics perform to characterize the acoustic features of marine habitats and their relation with ecosystem biodiversity. Our objectives were to 1) assess whether AM are able to capture the spectral and temporal differences between two distinct Antarctic marine acoustic environment types (i.e., pelagic vs. on‐shelf), 2) evaluate the performance of a combination of AM compared to the signal full frequency spectrum to characterize marine mammals acoustic assemblages (i.e., species richness–SR–and species identity) and 3) estimate the contribution of SR to the local marine acoustic heterogeneity measured by single AM. We used 23 different AM to develop a supervised machine learning approach to discriminate between acoustic environments. AM performance was similar to the full spectrum, achieving correct classifications for SR levels of 58% and 92% for pelagic and on‐shelf sites respectively and > 88% for species identities. Our analyses show that a combination of AM is a promising approach to characterize marine acoustic communities. It allows an intuitive ecological interpretation of passive acoustic data, which in the light of ongoing environmental changes, supports the holistic approach needed to detect and understand trends in species diversity, acoustic communities and underwater habitat quality.
Selective Fluorescent Turn‐Off Detection of Picric Acid Using a Novel Tripodal Supramolecular Triazole‐Trindane‐Based Receptor
Authors: Bharadwaj Vinita , Park Jung Eun , Sahoo Suban K , Choi Heung‐Jin 
Published: September 2019

AbstractApplying click chemistry, a new C3v‐symmetric tripodal supramolecular receptor L based on para‐nitrophenyl triazole trindane platform was introduced for the fluorescent turn‐off sensing of picric acid (PA). The selectivity of the receptor L was examined towards various nitroaromatic compounds, such as picric acid, 4‐nitrotoluene, 1‐chloro‐4‐nitrobenzene, m‐dinitrobenzene, 3‐nitrotoluene, 2‐nitrotoluene, nitrobenzene, p‐nitrophenol and 1‐chloro‐2‐nitrobenzene in aqueous DMSO medium. With micromolar detection limit, the receptor L showed selective fluorescence quenching at 421 nm in the presence of PA due to the energy transfer occurred from the receptor L to PA. The interaction between the receptor L and PA was complemented with the quantum mechanical calculations. Finally, the practical utility of L was validated by monitoring PA concentration in various real environmental water samples.
Co(II)‐Porphyrin Immobilized on Graphene Oxide: An Efficient Catalyst for the Beckmann Rearrangement
Authors: Ghadamyari Zohreh , Khojastehnezhad Amir , Seyedi Seyed Mohammad , Shiri Ali 
Published: September 2019

AbstractIn this report, the synthesis of amides from aldoximes (Beckmann rearrangement) has been reported using cobalt(II) porphyrin covalently linked to graphene oxide as a nano heterogeneous catalyst. The prepared catalyst was characterized by applying of FT‐IR, TGA, TEM, SEM, EDX, ICP and UV‐Vis techniques. All analyses confirm the successful insertion of cobalt into the porphyrin ring and covalently linkage of Co‐Porphyrin on the graphene oxide. Moreover, the prepared catalyst was applied in order to investigate its performance in the Beckmann rearrangement. This heterogeneous catalyst exhibited excellent catalytic efficiency with a high yield of products. Also, the suggested catalyst could be recycled for five runs without a dramatic decrease in its catalytic activity or metal leaching.
Antioxidant Properties of Rye Starch Films Containing Rosehip Extract and Their Application in Packaging of Chicken Breast
Authors: Go Eun‐Jeong , Song Kyung Bin 
Published: September 2019

AbstractStarch is extracted from rye and used as a film base material to develop a new biodegradable film. Different concentrations (0.4, 0.7, and 1.0 g per 100 mL) of rosehip extract (RHE) are incorporated as active materials to enhance the physicochemical properties of rye starch films. As the RHE concentration increases, the tensile strength of rye starch films decreases and elongation at break increases, resulting in improved flexibility of the films. The optical properties of the films are also enhanced by increasing opacity and decreasing light transmittance. Ultraviolet light is completely blocked. The antioxidant activities of the films are determined by evaluating 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulphonic acid) (ABTS) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activities. The highest ABTS and DPPH radical scavenging activities are observed for 1.0% RHE films (96.87% and 80.22%, respectively). Chicken breast samples wrapped with the 1.0% RHE film have lower peroxide and thiobarbituric acid reactive substances values than samples wrapped with film not containing RHE as well as the non‐packaged control, suggesting that lipid oxidation in the chicken breast is inhibited by the inclusion of RHE. The results indicate that rye starch films incorporated with RHE can be used as an active packaging material to retard lipid oxidation in foods.
Hybrid Reaction Systems for the Synthesis of Alkylated Compounds Based upon Cu‐Catalyzed Coupling of Radicals and Organometallic Species
Authors: Takeuchi Kentaro , Murata Yumi , Hirata Goki , Sheppard Tom D. , Nishikata Takashi 
Published: September 2019

AbstractA transition metal catalyzed alkylation with an alkyl halide is one of the most difficult reactions to achieve, because of the difficult oxidative addition of an alkyl‐halogen bond to a metal, and the tendency of the resulting alkylmetal intermediate to undergo a β‐hydride elimination reaction to give an olefin. In this review, we discuss hybrid reaction systems involving Cu catalyzed combination of radicals and organometallic species, which enable facile alkylation reactions to construct C−C and C‐heteroatom bonds. This paper highlights recent progress in arylation, alkenylation, alkynylation, cyclization, addition and introduction of heteroatoms via these hybrid reaction systems.