bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance Comparison of Knowledge-Based Dose Prediction Techniques Based on Limited Patient Data
Authors: Landers Angelia , Neph Ryan , Scalzo Fabien , Ruan Dan , Sheng Ke 
Published: November 2018

Purpose: The accuracy of dose prediction is essential for knowledge-based planning and automated planning techniques. We compare the dose prediction accuracy of 3 prediction methods including statistical voxel dose learning, spectral regression, and support vector regression based on limited patient training data. Methods: Statistical voxel dose learning, spectral regression, and support vector regression were used to predict the dose of noncoplanar intensity-modulated radiation therapy (4π) and volumetric-modulated arc therapy head and neck, 4π lung, and volumetric-modulated arc therapy prostate plans. Twenty cases of each site were used for k-fold cross-validation, with k = 4. Statistical voxel dose learning bins voxels according to their Euclidean distance to the planning target volume and uses the median to predict the dose of new voxels. Distance to the planning target volume, polynomial combinations of the distance components, planning target volume, and organ at risk volume were used as features for spectral regression and support vector regression. A total of 28 features were included. Principal component analysis was performed on the input features to test the effect of dimension reduction. For the coplanar volumetric-modulated arc therapy plans, separate models were trained for voxels within the same axial slice as planning target volume voxels and voxels outside the primary beam. The effect of training separate models for each organ at risk compared to all voxels collectively was also tested. The mean squared error was calculated to evaluate the voxel dose prediction accuracy. Results: Statistical voxel dose learning using separate models for each organ at risk had the lowest root mean squared error for all sites and modalities: 3.91 Gy (head and neck 4π), 3.21 Gy (head and neck volumetric-modulated arc therapy), 2.49 Gy (lung 4π), and 2.35 Gy (prostate volumetric-modulated arc therapy). Compared to using the original features, principal component analysis reduced the 4π prediction error for head and neck spectral regression (−43.9%) and support vector regression (−42.8%) and lung support vector regression (−24.4%) predictions. Principal component analysis was more effective in using all/most of the possible principal components. Separate organ at risk models were more accurate than training on all organ at risk voxels in all cases. Conclusion: Compared with more sophisticated parametric machine learning methods with dimension reduction, statistical voxel dose learning is more robust to patient variability and provides the most accurate dose prediction method.
Antibody-mediated immune suppression by antigen modulation is antigen-specific
Authors: Maier Cheryl L. , Mener Amanda , Patel Seema R. , Jajosky Ryan P. , Bennett Ashley L. , Arthur Connie M. , Hendrickson Jeanne E. , Stowell Sean R. 
Published: November 2018

Abstract
Alloantibodies developing after exposure to red blood cell (RBC) alloantigens can complicate pregnancy and transfusion therapy. The only method currently available to actively inhibit RBC alloantibody formation is administration of antigen-specific antibodies, a phenomenon termed antibody-mediated immune suppression (AMIS). A well-known example of AMIS is RhD immune globulin prophylaxis to prevent anti-D formation in RhD− individuals. However, whether AMIS is specific or impacts alloimmunization to other antigens on the same RBC remains unclear. To evaluate the specificity of AMIS, we passively immunized antigen-negative recipients with anti-KEL or anti-hen egg lysozyme (HEL) antibodies, followed by transfusion of murine RBC expressing both the HEL-ovalbumin-Duffy (HOD) and human KEL antigens (HOD × KEL RBC). Significant immunoglobulin G deposition on transfused HOD × KEL RBC occurred in all passively immunized recipients. Complement deposition and antigen modulation of the KEL antigen occurred on transfused RBC only in anti-KEL–treated recipients, whereas HEL antigen levels decreased only in the presence of anti-HEL antibodies. Western blot analysis confirmed the specificity of antigen loss, which was not attributable to RBC endocytosis and appears distinct for the 2 antigens. Specifically, removal of KEL was attenuated by clodronate treatment, whereas loss of HEL was unaffected by clodronate in vivo but sensitive to protease treatment in vitro. Antigen-specific modulation correlated with antigen-specific AMIS, with anti-KEL treated recipients forming antibodies to the HOD antigen and anti-HEL–treated recipients developing antibodies to the KEL antigen. Together, these results demonstrate that passively administered antibodies can selectively inhibit the immune response to a specific antigen.
High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (PlA1)
Authors: Zhi Huiying , Ahlen Maria Therese , Thinn Aye Myat Myat , Weiler Hartmut , Curtis Brian R. , Skogen Bjørn , Zhu Jieqing , Newman Peter J. 
Published: November 2018

AbstractAntibodies to platelet-specific antigens are responsible for 2 clinically important bleeding disorders: posttransfusion purpura and fetal/neonatal alloimmune thrombocytopenia (FNAIT). The human platelet-specific alloantigen 1a/1b (HPA-1a/1b; also known as PlA1/A2) alloantigen system of human platelet membrane glycoprotein (GP) IIIa is controlled by a Leu33Pro polymorphism and is responsible for ∼80% of the cases of FNAIT. Local residues surrounding polymorphic residue 33 are suspected to have a profound effect on alloantibody binding and subsequent downstream effector events. To define the molecular requirements for HPA-1a alloantibody binding, we generated transgenic mice that expressed murine GPIIIa (muGPIIIa) isoforms harboring select humanized residues within the plexin-semaphorin-integrin (PSI) and epidermal growth factor 1 (EGF1) domains and examined their ability to support the binding of a series of monoclonal and polyclonal HPA-1a–specific antibodies. Humanizing the PSI domain of muGPIIIa was sufficient to recreate the HPA-1a epitope recognized by some HPA-1a–specific antibodies; however, humanizing distinct amino acids within the linearly distant but conformationally close EGF1 domain was required to enable binding of others. These results reveal the previously unsuspected complex heterogeneity of the polyclonal alloimmune response to this clinically important human platelet alloantigen system. High-resolution mapping of this alloimmune response may improve diagnosis of FNAIT and should facilitate the rational design and selection of contemplated prophylactic and therapeutic anti–HPA-1a reagents.
When Collaboration Bridges Institutions: The Impact of University–Industry Collaboration on Academic Productivity
Authors: Bikard Michaël , Vakili Keyvan , Teodoridis Florenta 
Published: November 2018

Prior research suggests that academic scientists who collaborate with firms may experience lower publication rates in their collaborative lines of work because of industry’s insistence on intellectual property protection through patenting or secrecy. In contrast, we posit that university–industry collaboration can sometimes foster specialization and boost academic contribution to open science. Specifically, research lines with both scientific and commercial potential (i.e., in Pasteur’s quadrant) provide an opportunity for a productive division of tasks between academic scientists and their industry counterparts, whereby the former focus on exploiting the scientific opportunities and the latter focus on the commercial ones. The main empirical challenge of examining this proposition is that research projects that involve industry collaborators may be qualitatively different from those that do not. To address this issue, we exploit the occurrence of simultaneous discoveries where multiple scientists make roughly the same discovery around the same time. Following a simultaneous discovery, we compare the follow-on research output of academic scientists who collaborated with industry on the discovery with that of academic scientists who did not. We find that academic scientists with industry collaborators produced more follow-on publications and fewer follow-on patents than did academic scientists without industry collaborators. This effect is particularly salient when the research line has important commercial implications and when the industry partner is an established firm. The online appendix is available at https://doi.org/10.1287/orsc.2018.1235 .
Выражение „голосовать ногами / głosować nogami” в современном русском и польском языках
Authors: Miturska-Bojanowska Jolanta , Ignatowicz-Skowrońska Jolanta 
Published: November 2018

Since the end of the 20th century, in the Russian and Polish language the phrase голосовать ногами / głosować nogami has broadened its usage and its meaning in both languages. This refers to the primal Latin phrase pedibus in sententiam ire. Its popularity could be related to the influence of the English idiom vote with your feet.
Ocena użyteczności języka ojczystego (polskiego) w uczeniu się gramatyki języków obcych (angielskiego i rosyjskiego): wyniki badań
Authors: Wach Aleksandra , Jakowlewa-Pawlik Marina 
Published: November 2018

This article reports a study which gathered Polish learners’ opinions about the usefulness of L1-based techniques in learning L2 English and L3 Russian grammar. The results reveal a negative correlation between the length of study and the level of positive evaluations of the usefulness of L1-based clues. Although L1 was generally considered more useful in learning Russian, the evaluations differed considerably in relation to particular structures in both languages.
Прагматические и дидактические условия понимания иноязычного текста
Authors: Woźniewicz Władysław 
Published: November 2018

The article describes the linguistic, cultural, pragmatic conditions necessary for understanding foreign language texts. The main postulate of the article is that an adequate understanding of a text is dependent both on knowing the meaning of the individual words and interpreting their meaning in the text as a whole. A substantial and crucial part of the article is dedicated to the description of didactic activities for teachers aiming to develop the skills required for understanding foreign texts, both for beginners and advanced learners.
The deployable telescope: a cutting-edge solution for high spatial and temporal resolved Earth observation
Authors: Dolkens Dennis , Kuiper Hans , Corbacho Victor Villalba 
Published: November 2018

Abstract
The increase of spatial and temporal resolution for Earth observation (EO) is the ultimate driver for science and societal applications. However, the state-of-the-art EO missions like DigitalGlobe’s Worldview-3, are very costly. Moreover, this system has a high mass of 2800 kg and limited swath width of about 15 km which limits the temporal resolution. In this article, we present the status of the deployable space telescope (DST) project, which has been running for 6 years now at the Delft University of Technology, as a cutting-edge solution to solve this issue. Deployable optics have the potential of revolutionising the field of high resolution EO. By splitting up the primary mirror (M1) of a telescope into deployable segments and placing the secondary mirror (M2) on a deployable boom, the launch volume of a telescope can be reduced by a factor of 4 or more, allowing for much lower launch costs. This allows for larger EO constellations, providing image data with a much better revisit time than existing solutions. The DST specification baseline, based on Wordview-3, aims to provide images with a ground resolution of 25 cm (panchromatic 450–650 nm) from an orbital altitude of 500 km. In this paper, the current status of the optical, thermo-mechanical, and active optics systems design are described. The concurrent design approach combined with a strict bottom-up and top-down compliant systems engineering approach show that the DST is a healthy system concept.
On the equidistribution of some Hodge loci
Authors: Tayou Salim 
Published: November 2018

Abstract
We prove the equidistribution of the Hodge locus for certain non-isotrivial, polarized variations of Hodge structure of weight 2 with

h

2
,
0

=
1

{h^{2,0}=1}

over complex, quasi-projective curves. Given some norm condition, we also give an asymptotic on the growth of the Hodge locus. In particular, this implies the equidistribution of elliptic fibrations in quasi-polarized, non-isotrivial families of K3 surfaces.
Certain Laplace transforms of convolution type integrals involving product of two special pFp functions
Authors: Milovanović Gradimir V. , Parmar Rakesh K. , Rathie Arjun K. 
Published: November 2018

Abstract
Recently the authors obtained several Laplace transforms of convolution type integrals involving Kummer’s function 1F1 [Appl. Anal. Discrete Math., 2018, 12(1), 257-272]. In this paper, the authors aim at presenting several new and interesting Laplace transforms of convolution type integrals involving product of two special generalized hypergeometric functions pFp by employing classical summation theorems for the series 2F1, 3F2, 4F3 and 5F4 available in the literature.
Schauen Sie, was Sie hören – Wie das Gehirn mit allen seinen Sinnen die Welt wahrnimmt
Authors: Noppeney Uta , Jones Samuel A. , Rohe Tim , Ferrari Ambra 
Published: November 2018

Zusammenfassung
Unsere Sinne werden fortwährend mit den unterschiedlichsten Signalen bombardiert. Um dieses Sinneschaos zu verstehen, muss das Gehirn Sinnesreize integrieren, wenn sie von einer Quelle kommen, aber separate verarbeiten, wenn sie von unterschiedlichen Quellen kommen. Somit beruht multisensorische Wahrnehmung entscheidend auf dem Erfassen der kausalen Struktur, die die Sinnesreize erzeugt hat. Verhaltensstudien legen nahe, dass das Gehirn zwischen Integration and Segregation wie von normativen Modellen der Bayesianischen kausalen Inferenz vorhergesagt abwägt. Neueste funktionelle Magnetresonanztomographie (fMRI) und Elektroenzephalographie (EEG) Studien zeigten, dass das Gehirn Bayesianische kausale Inferenz durchführt, indem es mehrere Wahrnehmungsschätzwerte dynamisch auf verschiedenen Ebenen der corticalen Hierarchie der Sinnesverarbeitung enkodiert. Erst an der Spitze der Hierarchie in anterioren parietalen Arealen formt das Gehirn Wahrnehmungsschätzwerte, die die Ungewissheit des Beobachters über die kausal Struktur der Umgebung berücksichtigt, wie von Modellen der Bayesianischen kausalen Inferenz vorhergesagt.
Vom lateralen Rand ins Zentrum des Kortex: Die Entwicklung der menschlichen Inselrinde
Authors: Meyer Gundela 
Published: November 2018

Zusammenfassung
Die menschliche Inselrinde ist ein Hauptknotenpunkt in einem neuronalen Netzwerk, welches aus dem eigenen Körper stammende Erregungen mit Einflüssen aus der Umwelt integriert und dabei die autonome, emotionelle und sozial-kognitive Homöostase des Körpers erhält. Die Insel ist in den letzten Jahren ins Zentrum der Aufmerksamkeit gerückt. Vergleichende anatomische Untersuchungen haben gezeigt, dass die Insel in vielen Spezies am lateralen Rand des Neokortex liegt. Wenig erforscht ist die vorgeburtliche Entwicklung der menschlichen Insel, die sich als frühestes Kortexareal entwickelt. Ursprung der Pyramidalzellen der Insel ist ein kleiner Abschnitt der proliferativen Ventrikulär/Subventrikulärzone an der kortikostriatalen Grenze (KSG). Von den hier liegenden Zellen der radialen Glia, die als Stammzellen dienen, entspringt ein dichtgewebtes Faszikel aus Gliafortsätzen, welches durch die Capsula externa läuft und als Migrationssubstrat für die Neuroblasten aus der KSG in die Insel dient. Um die 10/11 Schwangerschaftswoche biegen sich der Lateralventrikel und die ihm anliegende KSG C-förmig um, sodass sich die Insel nun zwischen einer dorsalen fronto-parietalen und einer ventralen, temporalen KSG entwickelt und von diesen mit absteigenden bzw. aufsteigenden Migrationsströmen von Neuroblasten entlang des radialen Gliafaszikels versorgt wird. Als Folge der Ventrikelrotation wird die menschliche Insel während der Ontogenese vom lateralen Rand des Kortex in dessen Mittelpunkt verlagert, was im Einklang mit ihren integrativen Funktionen innerhalb der Hirnaktivität steht.
From the lateral edge to the center of the cortex: The development of the human insula
Authors: Meyer Gundela 
Published: November 2018

Abstract
The human insula is a key node in a neuronal network which integrates interoceptive stimuli from the own body, and exteroceptive stimuli from the environment, and thus maintains the autonomic, emotional and socio-cognitive homeostasis of the body. In the last years, the insula has come into the focus of attention. Comparative anatomical studies showed that in many species the insula forms the lateral edge of the cortex. Very little is known about the prenatal development of the human insula, which is the first cortical region to mature. The origin of the pyramidal neurons for the insula is a small sector of the proliferating ventricular/subventricular zone at the cortico-striatal boundary (CSB). The CSB contains the radial glia cells, which are stem cells and give rise to a dense fascicle of radial glia processes. This fascicle traverses the external capsule and serves as a migration substrate for the neuroblasts on their way from the CSB into the insula. Around the 10/11th week of gestation, the lateral ventricle and its adjacent structures including the CSB bend in a C-shaped fashion. The insula now develops between a dorsal, fronto-parietal and a ventral, temporal CSB, which provide descending and ascending streams of neuroblasts, respectively, migrating along the radial glia fascicle. As a consequence of the ventricular rotation during ontogenesis, the human insula changes its initial position at the lateral edge of the cortex to its final central location, which reflects its integrative functions in brain activity.
On route with harbor seals – how their senses contribute to orientation, navigation and foraging
Authors: Hanke Frederike D. , Dehnhardt Guido 
Published: November 2018

Summary
Summary: Seals and sea lions are well-oriented in their habitat, the coastal regions and oceans, and are, moreover, successful hunters. During their movements between haul-out places and foraging grounds as well as during foraging, the sensory systems of seals and sea lions provide useful information, although the animals, and thus their sensory systems, face considerable challenges in their habitat and due to their amphibious lifestyle. In this review, in the first chapter, we compiled and later (chapter 4) discuss the information on the senses of seals and sea lions in general and their specific adaptations to habitat and lifestyle in particular. We hereby focus on the senses of harbor seals. Harbor seals turned into a model organism regarding the sensory systems due to intensive sensory research of the last decades. In the second and third chapter, the sensory basics are put into the context of orientation, navigation, and foraging. This allows formulating new research questions, such as where and how the information from different senses is integrated.
Use of On-Demand Cloud Services to Model the Optimization of an Austenitization Furnace
Authors: Korambath Prakashan , Ganesh Hari S. , Wang Jianwu , Baldea Michael , Davis Jim 
Published: November 2018

Abstract
This article describes a smart manufacturing framework, comprising an on-demand, cloud-based deployment of a modeling application in a manufacturing operation. A specific use case, the optimization of the austenitization of steel parts, is presented. The framework uses a Kepler workflow as a cloud service to orchestrate and manage the data and computations required to implement a run-time model-based control and optimization approach on Amazon Web Services (AWS) resources. Austenitization is an energy intensive heat treating process commonly employed to harden and strengthen ferrous metals, such as steel. Pre-finished steel parts are heated to a specific temperature in a continuously operating industrial austenitization furnace without oxidizing the surface. The steel parts are then rapidly cooled or quenched in an oil bath. There is significant potential to optimize energy productivity by managing the energy usage needed to achieve the properties of the metal part instead of managing to operational process settings. Models of this process, which predict the furnace energy consumption and temperatures of parts as a function of time and position in the furnace and map temperatures to properties, have been previously developed; however, for operational use, the data and models need to be orchestrated for run-time operation, access to infrastructure, scalability, security, and support. A cloud-based approach is an alternative to the on-premise approach, in which an infrastructure for data, computational, and security needs to be built and maintained to support the application. A workflow service makes it possible to combine and sequence simulation and optimization software applications developed in several distinct MATLAB (The Mathworks Inc., Natick, MA) model configurations that are needed for various data-based calculations. The final output of the computation is the optimal operating condition of the furnace that minimizes the fuel consumption without violating the part target specifications. The workflow can be triggered on demand by an operator of the furnace or run at periodic intervals. All the computational resources required are instantiated and run at the start of the workflow and shutdown at the end of the workflow.
Domain Requirements and Genetic Interactions of the Mud1 Subunit of the Saccharomyces cerevisiae U1 snRNP
Authors: Agarwal Radhika , Schwer Beate , Shuman Stewart 
Published: November 2018

Abstract
Mud1 is an inessential 298-amino acid protein subunit of the Saccharomyces cerevisiae U1 snRNP. Mud1 consists of N-terminal and C-terminal RRM domains (RRM1 and RRM2) separated by a linker domain. Synthetic lethal interactions of mud1∆ with deletions of inessential spliceosome components Nam8, Mud2, and Msl1, or missense mutations in the branchpoint-binding protein Msl5 enabled us to dissect genetically the domain requirements for Mud1 function. We find that the biological activities of Mud1 can be complemented by co-expressing separately the RRM1 (aa 1-127) and linker-RRM2 (aa 128-298) modules. Whereas RRM1 and RRM2 (aa 197-298) per se are inactive in all tests of functional complementation, the linker-RRM2 by itself partially complements a subset of synthetic lethal mud1∆ interactions. Linker segment aa 155 to 196 contains a nuclear localization signal rich in basic amino acids that is necessary for RRM2 activity in mud1∆ complementation. Alanine scanning mutagenesis indicates that none of the individual RRM1 amino acid contacts to U1 snRNA in the cryo-EM model of the yeast U1 snRNP is necessary for mud1∆ complementation activity.