bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why IIoT should make businesses rethink security
Authors: Herbert Sean 
Published: July 2019

Companies of all sizes are revolutionising the way modern businesses operate by taking advantage of embedded sensors and cloud computing, making it possible for machines, industrial plants, factories and even construction sites to be connected as part of Industry 4.0. But the practice of securing technology and protecting networks from cybercrime has become increasingly difficult, as demonstrated by the catastrophic threats posed by cyber attacks on nuclear power plants across the US and power grids in the UK energy sector in 2017. Companies of all sizes are revolutionising the way modern businesses operate by taking advantage of embedded sensors and cloud computing. But securing technology and protecting networks has become increasingly difficult. Businesses urgently need holistic solutions that create transparency and traceability at a technical and organisational level. With more-complex IT infrastructures spanning thousands of endpoints, automation has become essential to streamline the detection and patching of vulnerabilities in a timely manner by making sure that every application is fully patched against that specific bug quickly and effectively, argues Sean Herbert of Baramundi.
HERODOTUS 6.105.2
Authors: Paolillo Davide 
Published: July 2019

This is the text of Hdt. 6.105.1–2, as printed by the most recent editors, Wilson and Hornblower–Pelling:καὶ πρῶτα μὲν ἐόντες ἔτι ἐν τῷ ἄστεϊ οἱ στρατηγοὶ ἀποπέμπουσι ἐς Σπάρτην κήρυκα Φιλιππίδην, Ἀθηναῖον μὲν ἄνδρα, ἄλλως δὲ ἡμεροδρόμην τε καὶ τοῦτο μελετῶντα· τῷ δή, ὡς αὐτός γε ἔλεγε Φιλιππίδης καὶ Ἀθηναίοισι ἀπήγγελλε, περὶ τὸ Παρθένιον ὄρος τὸ ὑπὲρ Τεγέης ὁ Πὰν περιπίπτει· βώσαντα δὲ τὸ οὔνομα τοῦ Φιλιππίδεω τὸν ΠᾶναἈθηναίους κελεῦσαι ἐπειρωτῆσαι, δι᾽ ὅ τι ἑωυτοῦ οὐδεμίαν ἐπιμελείαν ποιεῦνται, ἐόντος εὐνόου Ἀθηναίοισι καὶ πολλαχῇ γενομένου σφι ἤδη χρηστοῦ, τὰ δ᾽ ἔτι καὶ ἐσομένου.MSSἈθηναίοισι … ἀπαγγεῖλαιWilsonἈθηναίους … ἐπειρωτῆσαι
Using a Journal Club Series to Introduce Paramedic Students to Research Fundamentals and Critical Appraisal of Medical Literature
Authors: Maloney Lauren M. , Marshall Robert Trevor , Werfel Paul A. , Johnson Scott E. 
Published: July 2019

AbstractIntroduction:Despite United States national learning objectives referencing research fundamentals and the critical appraisal of medical literature, many paramedic programs are not meeting these objectives with substantive content.Problem:The objective was to develop and implement a journal club educational module for paramedic training programs, which is all-inclusive and could be distributed to Emergency Medical Services (EMS) educators and EMS medical directors to use as a framework to adapt to their program.Methods:Four two-hour long journal club sessions were designed. First, the educator provided students with four types of articles on a student-chosen topic and discussed differences in methodology and structures. Next, after a lecture about peer-review, students used search engines to verify references of a trade magazine article. Third, the educator gave a statistics lecture and critiqued the results section of several articles found by students on a topic. Finally, students found an article on a topic of personal interest and presented it to their classmates, as if telling their paramedic partner about it at work. Before and after the series, students from two cohorts (2017, 2018) completed a survey with questions about demographics and perceptions of research. Students from one cohort (2017) received a follow-up survey one year later.Results:For the 2016 cohort, 13 students participated and provided qualitative feedback. For the 2017 and 2018 cohorts, 33 students participated. After the series, there was an increased self-reported ability to find, evaluate, and apply medical research articles, as well as overall positive trending opinions of participating in and the importance of prehospital research. This ability was demonstrated by every student during the final journal club session. McNemar’s and Related-Samples Cochran’s Q testing of questionnaire responses suggested a statistically significant improvement in student approval of exceptions from informed consent.Conclusion:The framework for this paramedic journal club series could be adapted by EMS educators and medical directors to enable paramedics to search for, critically appraise, and discuss the findings of medical literature.
Signatures of structural differences in Pt–P- and Pd–P-based bulk glass-forming liquids
Authors: Gross Oliver , Neuber Nico , Kuball Alexander , Bochtler Benedikt , Hechler Simon , Frey Maximilian , Busch Ralf 
Published: July 2019

AbstractThe structural differences between the compositionally related Pt–P- and Pd–P-based bulk glass-forming liquids are investigated in synchrotron X-ray scattering experiments. Although Pt and Pd are considered to be topologically equivalent in structural models, we show that drastic changes in the total structure factor and in the reduced pair distribution function are observed upon gradual substitution. These variations indicate the existence of significant structural differences on the short- (SRO) and medium-range order (MRO) length scale. The structural data suggest that the distribution of the dominant polyhedra and the distribution of their connection schemes gradually change from Pt–P- to Pd–P-based alloys, which is likely connected to the different sensitivities to annealing or cooling rate induced embrittlement. The evolution of the total structure factor and the reduced pair distribution function with increasing temperature indicate the (partial) dissolution of both, the MRO and the SRO, which reflects the thermodynamic properties of the liquids.
Therapie des Antiphosphoplidsyndrom (APS) mit
DOAK
Authors: Bauersachs R. , Schellong S. , Stücker M. , Oldenburg J. , Kalka C. , Scholz U. , Lindhoff-Last E. 
Published: July 2019

ZusammenfassungDas Antiphospholipid-Syndrom ist eine der schwerwiegendsten thrombophilen
Störungen, die nicht nur zu rezidivierenden venösen, sondern auch zu arteriellen
Thromboembolien sowie Schwangerschaftskomplikationen führen kann. Zusammen mit
dem klinischen Bild ist das APS durch spezifische Laborbefunde charakterisiert:
1. Lupus Antikoagulans (LA), 2. Anticardiolipin-Antikörper (ACA), 3.
β2-Glykoprotein I-Antikörper (β2GPI-AK). Alle Testergebnisse müssen nach 12
Wochen bestätigt werden. Sind alle drei Testgruppen positiv, besteht das höchste
thrombotische Risiko. Beachtet werden muss, dass LA-Tests unter UFH, VKA oder
DOAKs falsch positiv ausfallen können; bei DOAKs scheint die Zugabe von
Absorbern nach Blutentnahme zuverlässige Ergebnisse zu liefern.Eine Vergleichsstudie (TRAPS) zwischen VKA und dem DOAK Rivaroxaban mit
ausschliesslich 3-fach positiven Hochrisiko-Patienten wurde vorzeitig
abgebrochen, wegen erhöhter Ereignisraten unter Rivaroxaban [19 % zumeist
arterielle Ereignisse versus 3 % unter Warfarin (HR 7.4; 1.7–32.9)]. Ein
daraufhin herausgegebener Rote-Hand-Brief warnt vor der Anwendung von DOAKs bei
Patienten mit APS, insbesondere bei Hoch-Risiko- (3-fach positiven) Patienten,
und empfiehlt die Überprüfung einer laufenden DOAK-Therapie und eine mögliche
Umstellung auf VKA, insbesondere bei Hoch-Risiko-Patienten. Als Fazit soll 1.
bei klinischem Verdacht eine sorgfältige APS-Diagnostik erfolgen. Viele
Patienten haben aufgrund von inadäquater Diagnostik wahrscheinlich gar kein APS
und können bei venöser Thromboembolie adäquat ein DOAK erhalten.2. Bei einfach- oder zweifach-positiven Antiphospholipid-AK Tests ohne LA besteht
ein vergleichbar niedriges Thromboserisiko; auch hier kann möglicherweise
ebenfalls mit DOAKs behandelt werden, wenn venöse Thrombosen vorliegen –
ausreichende Daten liegen noch nicht vor, aber Metaanalysen legen dies nahe. 3.
Patienten mit Positivität in allen 3 APS-Tests und APS-Patienten mit arteriellen
Thromboembolien haben ein sehr hohes Risiko. Die TRAPS-Studie zeigt, dass diese
Patienten nicht mit DOAKs, sondern mit einem VKA behandelt werden sollen.
Crizotinib-Associated Renal Cysts: A Case Series
Authors: Suman Garima , Patra Anurima , Janu Amit , Baheti Akshay 
Published: July 2019

AbstractCrizotinib is an anaplastic lymphoma kinase (ALK) inhibitor, used as a targeted chemotherapeutic agent in ALK-positive cases of nonsmall cell lung carcinoma. Although uncommon, it may be associated with the formation of new renal cysts, which may be simple or complex, or the enlargement of preexisting simple renal cysts or their transformation into complex cysts. These cysts usually regress partially or completely but may rarely enlarge over time or get complicated by infection or abscess formation. Such cases may even require dose reduction or withholding crizotinib. Although documented in clinical literature, this entity is not well known among radiologists. Knowledge of this entity helps in preventing erroneous diagnosis of the new kidney “lesion” as metastasis or disease progression and avoids an unnecessary biopsy. We describe a series of four cases which developed complex renal cysts during treatment with crizotinib to demonstrate this point.
Palaeomagnetism of Late Triassic volcanic rocks from the western margin of Khorat Basin, Thailand and its implication for ambiguous inclination shallowing in Mesozoic sediments of Indochina
Authors: Yan Yonggang , Zhao Qian , Zhang Donghai , Charusiri Punya , Huang Baochun , Zhang Peizhen 
Published: July 2019

SUMMARY
Palaeomagnetic constraints are essential factors in the reconstruction of the Mesozoic convergence of Eastern Asia blocks. As one of the key blocks, Indochina was constrained only by sedimentary-rocks-derived palaeomagnetic data. To evaluate whether the palaeomagnetic data used to restore the Late Triassic position of Indochina suffered inclination shallowing effects, we conducted a palaeomagnetic and geochronologic study on a coeval volcanic clastic rocks sequence in the western margin of the Khorat Basin, Thailand. The U-Pb SIMS dating on zircons indicates the age of the sampling section is between 205.1 ± 1.5 and 204.7 ± 1.4 Ma. Site mean directions are Dg/Ig = 217.2°/−39.4° (κg = 45.1, α95g = 10.1°) before and Ds/Is = 209.2°/−44.5° (κs = 43.8, α95s = 10.2°) after tilt correction. The new data set indicates a positive reversal test result at ‘Category C’ level. The characteristic remanent magnetization recorded by the coexistent magnetite and hematite is interpreted to be primary remanence acquired during the initial cooling of the volcanic clastic rocks. The consistence of the corresponding palaeolatitudes derived from the volcanic clastic rocks and the former reported sedimentary rocks suggests that there is probably no significant inclination shallowing bias in the sedimentary-rocks-derived palaeomagnetic data. Therefore, the estimates of the Late Triassic position of Indochina are confirmed to be reliable. The Indochina Block had collided to the southern margin of Eurasia by the Late Triassic and played an important role in the Mesozoic convergence of the Eastern Asia blocks.
ICSID’s Relevance for Africa: A Symbiotic Bond Beyond Time
Authors: Abdel Wahab Prof Dr Mohamed S 
Published: July 2019

Abstract
Africa's human, natural and legal diversity and wealth have always positioned the Continent as a desired investment destination. Historically, Africa contributed in shaping the ISDS system, and since the turn of the 21st Century, the Continent is witnessing considerable economic growth and is attracting many investors from around the world and especially China, which strengthens Africa's integration in the global economy. The past decade has also witnessed an increase in the number of BITs signed by African States, as well as in the number of investment legislations enacted and modernized. This article addresses the increase of investment in the African Continent, the new Belt and Road Initiative (BRI) and its potential for investments in the African Continent, sheds light on the status quo of the African arbitration landscape, provides an overview of the ICSID-Africa symbiotic relationship, emphasizes the uniqueness of the ICSID system in offering adequate dispute resolution schemes for investment disputes involving African parties and concludes by offering some concluding remarks and observations on the future of arbitration on the African Continent.
Genomic investigation of Staphylococcus aureus recovered from Gambian women and newborns following an oral dose of intra-partum azithromycin
Authors: Bojang Abdoulie , Baines Sarah L , Donovan Liam , Guerillot Romain , Stevens Kerrie , Higgs Charlie , Bottomley Christian , Secka Ousman , Schultz Mark B , Gonçalves da Silva Anders , Seemann Torsten , Stinear Timothy P , Roca Anna , Howden Benjamin P 
Published: July 2019

Abstract

Background
Oral azithromycin given during labour reduces carriage of bacteria responsible for neonatal sepsis, including Staphylococcus aureus. However, there is concern that this may promote drug resistance.

Objectives
Here, we combine genomic and epidemiological data on S. aureus isolated from mothers and babies in a randomized intra-partum azithromycin trial (PregnAnZI) to describe bacterial population dynamics and resistance mechanisms.

Methods
Participants from both arms of the trial, who carried S. aureus in day 3 and day 28 samples post-intervention, were included. Sixty-six S. aureus isolates (from 7 mothers and 10 babies) underwent comparative genome analyses and the data were then combined with epidemiological data. Trial registration (main trial): ClinicalTrials.gov Identifier NCT01800942.

Results
Seven S. aureus STs were identified, with ST5 dominant (n = 40, 61.0%), followed by ST15 (n = 11, 17.0%). ST5 predominated in the placebo arm (73.0% versus 49.0%, P = 0.039) and ST15 in the azithromycin arm (27.0% versus 6.0%, P = 0.022). In azithromycin-resistant isolates, msr(A) was the main macrolide resistance gene (n = 36, 80%). Ten study participants, from both trial arms, acquired azithromycin-resistant S. aureus after initially harbouring a susceptible isolate. In nine (90%) of these cases, the acquired clone was an msr(A)-containing ST5 S. aureus. Long-read sequencing demonstrated that in ST5, msr(A) was found on an MDR plasmid.

Conclusions
Our data reveal in this Gambian population the presence of a dominant clone of S. aureus harbouring plasmid-encoded azithromycin resistance, which was acquired by participants in both arms of the study. Understanding these resistance dynamics is crucial to defining the public health drug resistance impacts of azithromycin prophylaxis given during labour in Africa.
A 5-Year Continued Follow-up of Cancer Risk and All-Cause Mortality Among Norwegian Military Peacekeepers Deployed to Kosovo During 1999–2016
Authors: Strand Leif Aage , Martinsen Jan Ivar , Borud Einar Kristian 
Published: July 2019

Abstract

Introduction
In 2012, Norwegian news media reported on cases of brain cancer among Norwegian peacekeeping troops who served in Kosovo, allegedly caused by exposure to depleted uranium fired during airstrikes before the peacekeepers arrived in 1999. A first study followed 6076 military men and women with peacekeeping service in Kosovo during 1999–2011 for cancers and deaths throughout 2011. The study did not support to the idea that peacekeeping service in Kosovo could lead to increased risk of brain cancer or other cancers. However, the average time of follow-up (10.6 years) was rather short for cancer development; therefore the aim of the present study was to evaluate cancer risk and general mortality in an updated cohort after 5 years of additional follow-up.

Materials and Methods
The updated cohort consisted of 6,159 peacekeepers (5,884 men and 275 women) who served in Kosovo during 1999–2016 and were followed for cancer incidence and mortality from all causes combined throughout 2016. We calculated standardized incidence ratios (SIR) for cancer and standardized mortality ratios (SMR) from national population rates. Poisson regression was used to assess the effect of length of service (<1 year vs. ≥1 year) on cancer risk.

Results
We observed 149 cancer cases and 75 deaths in the updated cohort. Observed cancer incidence did not exceed national rates. In men, the SIR for brain cancer was 0.73 (95% confidence interval (CI) 0.32–1.44), based on eight cases, while the risk of colon cancer was lowered (SIR = 0.14, 95% CI 0.00–0.79). The Poisson regression showed no effect of service duration on all-site cancer incidence. Mortality from all causes combined was lower than expected (SMR = 0.62, 95% CI 0.49–0.78) and in accordance with a “healthy soldier effect”.

Conclusion
The extended follow-up did not give support to the suggestion that peacekeeping service in Kosovo could lead to increased risk of cancer.
3D MHD simulations and synthetic radio emission from an oblique rotating magnetic massive star
Authors: Daley-Yates S , Stevens I R , ud-Doula A 
Published: July 2019

ABSTRACT
We have performed 3D isothermal MHD simulation of a magnetic rotating massive star with a non-zero dipole obliquity and predicted the radio/sub-mm observable light curves and continuum spectra for a frequency range compatible with ALMA. From these results we also compare the model input mass-loss to that calculated from the synthetic thermal emission. Spherical and cylindrical symmetry is broken due to the obliquity of the stellar magnetic dipole resulting in an inclination and phase dependence of both the spectral flux and inferred mass-loss rate, providing testable predictions of variability for oblique rotator. Both quantities vary by factors between 2 and 3 over a full rotational period of the star, demonstrating that the role of rotation as critical in understanding the emission. This illustrates the divergence from a symmetric wind, resulting in a two-armed spiral structure indicative of an oblique magnetic rotator. We show that a constant spectral index, α, model agrees well with our numerical prediction for a spherical wind for ν &lt; 103 GHz; however it is unable to capture the behaviour of emission at ν &gt; 103 GHz. As such we caution the use of such constant α models for predicting emission from non-spherical winds such as those which form around magnetic massive stars.
β Pictoris: observations of the Ca ii H&K absorptions in 1997 and 1998
Authors: Tobin William , Barnes Stuart I , Persson Stephen , Pollard Karen R 
Published: July 2019

ABSTRACT
We present spectroscopy with resolution R ∼ 33 000 of the circumstellar Ca ii H&K absorptions in the star β Pictoris during 1997 and 1998. From 1997 April onwards, both lines were observed simultaneously. A total of 688 spectra were obtained over 95 nights in order to characterize the lines’ behaviour. Near-continuous Falling Evaporating Body (FEB) variable absorption activity was seen, including additional strong, blueshifted features besides the one on 1997 June 19–20 already reported by others. Temporal coverage is more even than in the HARPS spectra from 2004–11 that have been analysed for FEB orbital parameters via a model of FEB evaporation. Our observations likely encompass the 1997–98 Hill-sphere transit by β Pic b, but we have found no clear signature of transiting material. Lower velocity FEB absorptions tend to be deeper, narrower and longer lived, in confirmation of earlier studies. The ratio of line strengths for one absorption on 1998 November 27 is evocative of the variations expected for a single FEB making a transit perpendicular to the stellar rotation axis. Analysis with the evaporation model produces similar distributions of orbital parameters to those obtained from the HARPS observations, but when the derived orbital parameters are fed into a model based solely on gravitational dynamics of point masses, the predicted FEB accelerations do not agree with observed values. More sophisticated modelling is called for. There is no convincing intrinsic variation in the central circumstellar absorption such as might be expected if an H i ring is responsible for the confinement of circumstellar Ca+ ions. Our observations are available electronically for further analysis by others.
Cosmological exploitation of the size function of cosmic voids identified in the distribution of biased tracers
Authors: Contarini Sofia , Ronconi Tommaso , Marulli Federico , Moscardini Lauro , Veropalumbo Alfonso , Baldi Marco 
Published: July 2019

Abstract
Cosmic voids are large underdense regions that, together with galaxy clusters, filaments and walls, build-up the large-scale structure of the Universe. The void size function provides a powerful probe to test the cosmological framework. However, to fully exploit this statistics, the void sample has to be properly cleaned from spurious objects. Furthermore, the bias of the mass tracers used to detect these regions has to be taken into account in the size function model. In our work, we test a cleaning algorithm and a new void size function model on a set of simulated dark matter halo catalogues, with different mass and redshift selections, to investigate the statistics of voids identified in a biased mass density field. We then investigate how the density field tracers’ bias affects the detected size of voids. The main result of this analysis is a new model of the size function, parametrized in terms of the linear effective bias of the tracers used, which is straightforwardly inferred from the large-scale two-point correlation function. This method is a crucial step in exploiting real surveys. The proposed size function model has been accurately calibrated on halo catalogues, and used to validate the possibility to provide forecasts on the cosmological constraints, namely on the matter density contrast, ΩM, and on the normalization of the linear matter power spectrum, σ8, at different redshifts.
LTMG: a novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data
Authors: Wan Changlin , Chang Wennan , Zhang Yu , Shah Fenil , Lu Xiaoyu , Zang Yong , Zhang Anru , Cao Sha , Fishel Melissa L , Ma Qin , Zhang Chi 
Published: July 2019

AbstractA key challenge in modeling single-cell RNA-seq data is to capture the diversity of gene expression states regulated by different transcriptional regulatory inputs across individual cells, which is further complicated by largely observed zero and low expressions. We developed a left truncated mixture Gaussian (LTMG) model, from the kinetic relationships of the transcriptional regulatory inputs, mRNA metabolism and abundance in single cells. LTMG infers the expression multi-modalities across single cells, meanwhile, the dropouts and low expressions are treated as left truncated. We demonstrated that LTMG has significantly better goodness of fitting on an extensive number of scRNA-seq data, comparing to three other state-of-the-art models. Our biological assumption of the low non-zero expressions, rationality of the multimodality setting, and the capability of LTMG in extracting expression states specific to cell types or functions, are validated on independent experimental data sets. A differential gene expression test and a co-regulation module identification method are further developed. We experimentally validated that our differential expression test has higher sensitivity and specificity, compared with other five popular methods. The co-regulation analysis is capable of retrieving gene co-regulation modules corresponding to perturbed transcriptional regulations. A user-friendly R package with all the analysis power is available at https://github.com/zy26/LTMGSCA.