bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ovarian cancer G protein-coupled receptor 1 inhibits A549 cells Migration through Casein kinase 2α intronless gene
Authors: Sharma Adhikarimayum Lakhikumar , Meitei Puyam Milan , Singh Naorem Tarundas , Singh Thiyam Ramsing , Singh Lisam Shanjukumar 
Published: February 2019

AbstractWe have previously reported that ovarian cancer G protein-coupled receptor 1 (OGR1) is a new metastasis suppressor gene. We have also reported for the first time that a new intronless gene for casein kinase 2α (CSNK2A3) is expressed in human cells. The promoter of the well-known casein kinase 2α (CSNK2A1) displays characteristics of housekeeping gene whereas CSNK2A3 has a characteristic of a regulated promoter with two TATA boxes and a CAAT box. In this study, we found that OGR1 up-regulates expression of CSNK2A3 by about 3 folds in A549 cells but not CSNK2A1. OGR1 also up-regulates expression of neutral endopeptidase (NEP). The OGR1 induced inhibition of A549 cell migration is completely abrogated by inhibition of casein kinase 2α activity, whereas partial abrogation (~ 30%) was observed in the presence of NEP inhibition. The results also revealed that OGR1 regulates CSNK2A3 via activation of Rac1/cdc42 and MAPKs pathways. CK2 is ubiquitously expressed and in contrast it is believed to be a constitutively active enzyme and its regulation appears to be independent of known second messengers. There is no previous report on how expression of CK2α in cancer cells is regulated although many studies have report of aberrant expression of the kinase in cancer. In the current study, we are reporting for the first time the regulation of intronless casein kinase 2α gene, CSNK2A3 in cancer cells. Our findings suggest that the aberrantly casein kinase 2α expression found in various cancer cells may the due to CSNK2A3 expression which is potentially regulated by several master regulators of the developmental pathways rather than well-known casein kinase 2α gene, CSNK2A1.
Positive selection in the Ebola virus proteome
Authors: Dasmeh Pouria 
Published: February 2019

AbstractTo gain insight into the recent evolution of EBOLA virus (EBOV) proteins and identify evolutionary hotspots, I investigated patterns of amino acid substitutions in the proteomes of 49 members of EBOV genus including EBOV, Bundibugyo virus (BDBV), Reston virus (RESTV), Sudan virus (SUDV) and Taï Forest virus (TAFV) spanning outbreaks from 1974 to 2014 in Democratic Republic of Congo (DRC), Uganda, Gabon, Sudan, Ivory Coast, Philippines, and Guinea among humans, non-human primates, and pigs. Of the seven genes of the Ebola genome, I found significant variations in evolutionary rates of Glycoprotein (GP), RNA/dependent RNA polymerase (L), and Nucleoprotein (NP) across different lineages. GP and NP were found to evolve at 5- and 3-fold higher rate than other EBOV genes. Several residues in GP and NP show significant dN/dS>1 along the internal branches of the phylogenetic tree leading to Philippines and Sudan outbreaks. Most of these residues are located in solvent exposed areas shown previously to be antigenic. We further identified significant changes in specific amino acid properties of GP, NP and L during the recent evolutionary history of EBOV outbreaks and in particular during the 2014 outbreak. The positively selected residues and chemical properties are consistent with changes in epitope interaction and could thus be important in detecting adaptation of EBOV to the host immune defense system.
Flooding and hydrologic connectivity modulate community assembly in a dynamic river-floodplain ecosystem
Authors: Larsen Stefano , Karaus Ute , Claret Cecile , Sporka Ferdinand , Hamerlík Ladislav , Tockner Klement 
Published: February 2019

SummaryBraided river floodplains are highly dynamic ecosystems, where aquatic communities are strongly regulated by the hydrologic regime. So far, however, understanding of how flow variation influences assembly mechanisms remains limited.We collected benthic chironomids and oligochaetes over a year across a lateral connectivity gradient in the semi-natural Tagliamento River (Italy). Four bankfull flood events occurred during the study, allowing the assessment of how flooding and hydrologic connectivity mediate the balance between stochastic and deterministic community assembly.While invertebrate density and richness were positively correlated with connectivity, diversity patterns showed no significant correlation. Species turnover through time increased with decreasing connectivity. Contrary to expectations, hydrologic connectivity did not influence the response of community metrics (e.g. diversity, density) to floods.Invertebrate composition was weakly related to connectivity, but changed predictably in response to floods. Multivariate ordinations showed that faunal composition diverged across the waterbodies during stable periods, reflecting differential species sorting across the lateral gradient, but converged again after floods. Stable hydrological periods allowed communities to assemble deterministically with prevalence of non-random beta-diversity and cooccurrence patterns and larger proportion of compositional variation explained by local abiotic features. These signals of deterministic processes clearly declined after flooding events. This occurred despite no apparent evidence of flood-induced homogenisation of habitat conditions.This study is among the first to examine the annual dynamic of aquatic assemblages across a hydrologic connectivity gradient in a natural floodplain. Results highlight how biodiversity can exhibit complex relations with hydrologic connectivity. However, appraisal of the assembly mechanisms through time indicated that flooding shifted the balance from deterministic species sorting across floodplain habitats, towards stochastic processes related to organisms redistribution and the likely resetting of assembly to earlier stages.
Are students’ mindsets those of typical start-up founders?
Authors: Rungi Mait 
Published: February 2019

Purpose
Studies have found that founders of start-up companies are similar to students in certain psychological characteristics. Confirming this similarity would have methodological and phenomenological implications. Phenomenologically, students are a main source for recruitment in start-up companies. Methodologically, students are a more convenient sample to study than start-up founders. The paper aims to discuss these issues.

Design/methodology/approach
The resemblance between students and start-up founders is tested by analyses of variance of the responses of 1,509 students and 53 start-up founders to a questionnaire survey.

Findings
The results indicate that, as a population, students are not entirely similar to start-up founders, though similarities were found to exist. The closest resemblance between students and founders was found for managerial, armed forces/police and medicine students; agricultural, humanities and natural science students had the least resemblance.

Originality/value
Although student samples are commonly used in the study of management phenomena, the validity of this approach has not hitherto been tested, which indicates that the use of student subjects as stand-ins for start-up founders may be a practice without a solid foundation.
Board independence and internal control quality in Egypt: does CEO duality matter?
Authors: Khlif Hichem , Samaha Khaled 
Published: February 2019

Purpose
This paper aims to examine the relationship between board independence and internal control quality (ICQ) in Egypt and investigate whether CEO duality moderates such an association.

Design/methodology/approach
A survey among external auditors is used to assess ICQ among Egyptian listed firms over the period of 2007-2010.

Findings
Findings show that board independence does not have a significant positive effect on ICQ. However, when testing for the moderating effect of CEO duality on such a relationship, the authors document that the association becomes positive and significant under combined board leadership structure, whereas it is negative under separated leadership structure.

Originality/value
The authors’ results demonstrate that CEO duality plays a governance role in weak legal environment like Egypt by strengthening board independence role in increasing ICQ.
Municipal charges on communal waste: do they compete with the immovable property tax?
Authors: Radvan Michal 
Published: February 2019

Purpose
The purpose of this paper is to give a recommendation to the municipalities what local tax/taxes sensu largo (a waste charge or an immovable property tax increased by a local coefficient) are to be collected to achieve expected and necessary incomes and limit the administrative costs.

Design/methodology/approach
To reach the aim, it was necessary to analyze the number of municipalities increasing the property tax by the local coefficient and abolishing the charge on communal waste to save money for the waste charges administration. The evidence of municipalities applying the local coefficient was used as a basis for the research. To get the information on charges on communal waste collected in these municipalities with the local coefficient within the past at least five taxable periods, the information from Monitor was used. If there was any such a significant change, then it was necessary to use the bylaws and to do thorough analysis of the reasons.

Findings
The hypothesis that a high number of municipalities in the Czech Republic are replacing the charge on communal waste with the local coefficient applicable for the immovable property tax was rejected. In the opinion of the author, the ideal approach is to have just one local tax – immovable property tax. This tax is administered by the state tax office and the revenue should cover the cost of waste management. Adopting only the property tax increased by the local coefficient, it is necessary to explain the benefits to the taxpayers, that is, locals and voters.

Originality/value
The research on the given topic was never done in the Czech Republic, as there is no evidence of local charges collected in individual municipalities.
Social media and the police
Authors: Hu Xiaochen , Lovrich Nicholas P. 
Published: February 2019

PurposeMost police agencies in the USA make the claim that they use social media, and such use is drawing a great academic attention. Most studies on police use of social media focus on the content of police social media websites. Little research, however, has been conducted regarding what types of police agencies are in fact making use of social media. The purpose of this paper is to fill this gap in the knowledge.Design/methodology/approachThe study reported here analyzes the 2013Law Enforcement Management and Administrative Statistics(LEMAS) data set to identify the principal organizational characteristics of police agencies associated with the use of social media. Binary logistic regression is used to identify significant independent predictors of police use of social media, viewed here as a form of innovation.FindingsThe findings indicate that the workforce size (commissioned and civilian personnel) of a police agency, the level of participation in multi-jurisdictional task forces and the early use of an official agency website to communicate with the public are the predictors of police use of social media.Research limitations/implicationsThree theories pertaining to organizational behavior (i.e. contingency theory, institutional theory, and resource dependency theory), as well as Maguire’s (2003) study, are used to establish the theoretical framework for the research reported here.Originality/valueViewed as a pioneering study testing organizational theories related to police use of social media, the current study sets forth findings that help deepen the collective understanding of contingency theory, institutional theory and resource dependency theory as frameworks for explaining organizational behavior in policing.
2D cooperative inversion of direct current resistivity and gravity data: A case study of uranium bearing target rock
Authors: Singh Anand , Mishra Pankaj K. , Sharma S.P. 
Published: February 2019

ABSTRACTInterpretation of a single geophysical data set is not sufficient to get complete subsurface information. Cooperative or joint inversion of geophysical data sets is the preferred method for most case studies. In the present study, we present the results of the cooperative inversion approach of direct current resistivity and gravity data. The algorithm uses fuzzy c‐means clustering to determine the petrophysical relationship between density and resistivity to obtain the similarity. Synthetic data set has demonstrated that the cooperative inversion approach can produce more reliable and better resistivity and density models of the subsurface as compared to those obtained through individual inversions. To utilize the presented cooperative inversion algorithm, the number of geologic units (number of clusters) in the study region must be known a priori. As a field study, the cooperative inversion approach was used to identify the extension of uranium‐bearing target rock around the Beldih open cast mine. We noted the inconsistencies in both resistivity and density models obtained from the individual inversions. However, the presented cooperative inversion approach was able to produce similar resistivity and density models while maintaining the same error level of the respective individual inversions. We have considered four geologic units in the presented cooperative inversion as a field case study. We have also compared our cooperative results with drilled borehole and found to be a reliable tool to differentiate between the target rocks (kaolinite and quartz–magnetite–apatite rocks) and the ultramafic rock (host rock quartzite/alkaline granite). However, this study is subject to certain limitations such as the inability to differentiate between closely spaced kaolinite and quartz–magnetite–apatite rocks.
Slowness‐domain kinematical characteristics for horizontally layered orthorhombic media. Part I: Critical slowness match
Authors: Ravve Igor , Koren Zvi 
Published: February 2019

ABSTRACTKinematical characteristics of reflected waves in anisotropic elastic media play an important role in the seismic imaging workflow. Considering compressional and converted waves, we derive new, azimuthally dependent, slowness‐domain approximations for the kinematical characteristics of reflected waves (radial and transverse offsets, intercept time and traveltime) for layered orthorhombic media with varying azimuth of the vertical symmetry planes. The proposed method can be considered an extension of the well‐known ‘generalized moveout approximation’ in the slowness domain, from azimuthally isotropic to azimuthally anisotropic models. For each slowness azimuth, the approximations hold for a wide angle range, combining power series coefficients in the vicinity of both the normal‐incidence ray and an additional wide‐angle ray. We consider two cases for the wide‐angle ray: a ‘critical slowness match’ and a ‘pre‐critical slowness match’ studied in Parts I and II of this work, respectively. For the critical slowness match, the approximations are valid within the entire slowness range, up to the critical slowness. For the ‘pre‐critical slowness match’, the approximations are valid only within the bounded slowness range; however, the accuracy within the defined range is higher. The critical slowness match is particularly effective when the subsurface model includes a dominant high‐velocity layer where, for nearly critical slowness values, the propagation in this layer is almost horizontal. Comparing the approximated kinematical characteristics with those computed by numerical ray tracing, we demonstrate high accuracy.
Reflexivity denied? The emotional and health‐seeking resources of men facing disadvantage
Authors: Simpson Paul , Richards Michael 
Published: February 2019

AbstractBased on focus group discussions of self‐generated photographs of individuals aged 19–67 resident in urban Northwest England, this article examines the health narratives of men facing disadvantage because of economic hardship and/or mental health difficulty (mhd). In contrast to stereotypes of men as uncomfortable with emotions linked to vulnerability, we explore how such men can develop within self‐help groups the kind of emotional resources that encourage health‐seeking behaviours. Our argument contrasts with theories that risk denying/diminishing working‐class men's emotional reflexivity or that frame reflexivity (thought on feelings and behaviour to effect life changes) as individualised and more available to middle‐class (younger) men. We argue that participant accounts indicate development of more collective emotional and epistemic resources from a position of subordinated masculinity. This argument challenges stereotypes of working‐class men as lacking in knowledge/skill in health and self‐care. Collective reflexivity over health/wellbeing was particularly visible in three main accounts that emerged during focus groups: involvement in self‐help ‘communities of practice’, use of local aesthetic spaces and negotiation with/qualified challenge to healthy eating discourse.
Detection and Classification of Ignitable Liquid Residues in the Presence of Matrix Interferences by Using Direct Analysis in Real Time Mass Spectrometry,
Authors: Barnett Isabella , Bailey Frank C. , Zhang Mengliang 
Published: February 2019

AbstractConventional Gas Chromatography‐Mass Spectrometry (GC‐MS) methods for the analysis of ignitable liquids (ILs) are usually time‐consuming, and the data produced are difficult to interpret. A fast IL screening method using direct analysis in real time mass spectrometry (DART‐MS) is proposed in this study. GC‐MS, QuickStrip DART‐MS, and thermal desorption DART‐MS methods were used to analyze neat ILs and thermal desorption DART‐MS without extraction was used to analyze ILs on five substrates (e.g., carpet, wood, cloth, sand, and paper). Compared to GC‐MS, DART‐MS methods generated different spectral profiles for neat ILs with more peaks in the higher mass range and also provided better detection of less volatile compounds. ILs on substrates were successfully classified (98 ± 1%) using partial least squares discriminant analysis (PLS‐DA) models based on thermal desorption DART‐MS data. This study shows that DART‐MS has great potential for the high‐throughput screening of ILs on substrates.
Resolution of acenocoumarol‐associated calciphylaxis with drug withdrawal
Authors: Suárez‐Peñaranda José‐Manuel , Minasyan Anna , Sainz‐Gaspar Laura , Sánchez‐Aguilar María‐Dolores 
Published: February 2019

AbstractCalciphylaxis is a syndrome of cutaneous ischaemic necrosis and ulceration due to arteriolar calcification with subsequent thrombosis, which rarely presents in patients without terminal kidney disease. Recently, several reports of coumarins‐associated calciphylaxis have stressed the relevance of anticoagulant therapy as an important risk factor for the development of this condition. We report five cases of acenocoumarol‐associated, biopsy‐proven calciphylaxis in women aged between 64 and 92 years. The drug had been prescribed for atrial fibrillation and was taken without interruption from 14 to 224 months. Lesions were present for months in all cases and were resistant to multiple therapeutic options, but they resolved only with simple wound care measures 6–14 months after changing the anticoagulant therapy.
Of Two Minds, But One Heart: A Good “Gut” Feeling Moderates the Effect of Ambivalence on Attitude Formation and Turnout
Authors: Groenendyk Eric 
Published: February 2019

AbstractPopular psychological accounts argue that successful candidates address their appeals to citizens’ “hearts” rather than their “heads.” Yet research on campaigns shows that candidates win elections by getting voters to think about particular issues—especially issues that create ambivalence in the minds of opposition supporters. This article helps to reconcile these “heart‐centered” and “head‐centered” accounts of preference formation during campaigns. An original experiment and ANES data analyses (1980–2004) show that a “good gut feeling” toward a candidate helps citizens to overcome the paralyzing effect of ambivalence on attitude formation and turnout. And, since turnout is most tenuous among those with lower income, this is where the effect is most pronounced. Since Democratic candidates rely disproportionately on support from these lower‐income voters, it is particularly important that they inspire positive affect among latent supporters.
Rural centres do not have a higher prevalence of post‐operative complications than urban centres: a retrospective analysis of a mortality audit
Authors: Ferrah Noha , Stephan Karen , Lovell Janaka , Beiles Charles B. , Ibrahim Joseph E. 
Published: February 2019

BackgroundThe trend towards centralization of surgical care from rural to high‐volume centres is based on studies showing better outcomes for patients requiring complex surgical procedures. However, evidence that this also applies to less complex procedures is lacking. This study therefore aimed to determine whether there was a relationship between geographic location (rural versus urban) of surgical procedures of varying complexity and post‐operative complications.MethodsThis was a retrospective cohort study examining all in‐hospital deaths reported to the Australian and New Zealand Audit of Surgical Mortality (ANZASM) between 2009 and 2016. Multivariable logistic regression was used to ascertain interactive effects of location and complexity of surgical procedures on post‐operative complications, adjusted for potential confounders.ResultsThere was no interactive effect of hospital location and operation complexity on the occurrence of post‐operative complications. Post‐operative complications were reported in 2160 of 6963 (31%) patients who died post‐surgery. Patients operated on in rural centres had lower risk profiles: younger, with lower American Society of Anesthesiologists grades and less likely to present with injury and circulatory diseases. Nonetheless, risk of post‐operative complications did not differ between procedures performed in rural compared with urban hospitals.ConclusionResults of this study suggest that a wide range of procedures may be safely performed in rural centres. Further prospective studies of unfiltered cohorts are warranted to validate these findings.
Parental reports showed that snoring in infants at three and eight months associated with snoring parents and smoking mothers
Authors: Katila Maija , Saarenpää‐Heikkilä Outi , Saha Marja‐Terttu , Vuorela Nina , Paavonen E. Juulia 
Published: February 2019

AbstractAimThis prospective study examined the prevalence of snoring during infancy and the prenatal and postnatal risk factors for this condition.MethodsThe study population comprised 1388 infants from the CHILD‐SLEEP birth cohort, who were recruited in the Pirkanmaa Hospital District, Finland, between 2011 and 2013. Sleep and background factor questionnaires were filled out prenatally by parents and when the infant was three and eight months old.ResultsThe prevalence of habitual snoring was 3.2% at the age of three months and 3.0% at eight months, and snoring infants had more sleeping difficulties at those ages, with odds ratios (ORs) of 3.11 and 4.63, respectively. At three months, snoring infants slept for a shorter length of time (p = 0.001) and their sleep was more restless (p = 0.004). In ordinal logistic regression models, parental snoring (adjusted OR = 1.65 and 2.60) and maternal smoking (adjusted OR = 2.21 and 2.17) were significantly associated with infant snoring at three and eight months, while formula feeding and dummy use (adjusted OR = 1.48 and 1.56) were only associated with infant snoring at three months.ConclusionParental snoring and maternal smoking increased the risk of snoring. Infants who snored also seemed to suffer more from other sleep difficulties.