bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interoceptive Awareness Is Associated With Impaired Awareness of Hypoglycemia in Adults With Type 1 Diabetes
Authors: Matus Austin M. , Riegel Barbara , Rickels Michael R. 
Published: November 2024

OBJECTIVE
To assess the association between impaired awareness of hypoglycemia (IAH) and interoceptive awareness in type 1 diabetes.

RESEARCH DESIGN AND METHODS
A total of 154 adults with type 1 diabetes completed IAH surveys and the Multidimensional Assessment of Interoceptive Awareness, Version 2 (MAIA-2). Logistic regression was performed for assessment of associations between IAH and MAIA-2, accounting for covariates.

RESULTS
Significant relationships were observed between IAH and two MAIA-2 scales. Each 1-point increase on the Not-Worrying subscale was associated with 87% increased odds of IAH (odds ratio 1.87, CI 1.01–3.46) and on the Attention Regulation subscale was associated with 72% decreased odds of IAH (0.28, 0.12–0.66). Compared with scoring &gt;90th percentile for Attention Regulation, scoring &lt;10th percentile and scoring in the 10th–90th percentiles were associated with 71-fold (71.26, 3.42–1482.10) and 12-fold (12.73, 1.19–135.57) increased odds of IAH, respectively.

CONCLUSIONS
Less worry about and reduced ability to sustain and control attention to body sensations were associated with significantly increased odds of IAH.
INTELIGÊNCIA ARTIFICIAL: CONTEXTOS, EVOLUÇÕES TECNOLÓGICAS E O POTENCIAL TRANSFORMADOR DA IA PARA ARQUITETURA, URBANISMO E DESIGN
Authors: Vieira Marcos Vinicius , Bremer Cynara Fiedler , Oliveira Géferson Diogo de , Silva Patrícia Raquel Yegros da 
Published: November 2024

Este artigo apresenta uma breve contextualização histórica e uma análise tripartite da evolução tecnológica, além de introduzir os conceitos e fundamentos da inteligência artificial (IA). O objetivo é desmistificar esse campo do conhecimento para estudantes de arquitetura, urbanismo e design. A IA, com suas diversas aplicações, tem o potencial de revolucionar esses campos, oferecendo novas ferramentas e métodos para a criação e análise de espaços urbanos e edificações. Foi realizada uma análise qualitativa de ilustrações de uma cidade do livro Cidades Invisíveis, de Italo Calvino, geradas por meio de ferramentas de IA. Essas ilustrações foram comparadas com as descrições literárias para avaliar a precisão e a criatividade das representações geradas. A análise revelou que a IA pode capturar a essência das descrições de Calvino, ao mesmo tempo em que introduz novas interpretações visuais que podem inspirar arquitetos e designers. Além disso, o artigo discute as implicações éticas e práticas do uso da IA na arquitetura e no urbanismo, destacando a importância de uma abordagem crítica e informada. Conclui-se que, embora a IA ofereça inúmeras possibilidades, é essencial que os profissionais dessas áreas compreendam suas limitações e potencialidades para utilizá-la de forma eficaz e responsável.
THE IMPACT OF MATERNAL SECOND SIGNAL SYSTEM ACTIVITY ON MOTHER-CHILD INTERACTIONS DURING THE VERBAL DEVELOPMENT STAGE IN THE CONTEXT OF WAR AND HEALTH CRISES
Authors: Znamenska T. , Lunev V. , Zbrozhyk Y. , Prudka L. , Zhuk O. 
Published: November 2024

The transition from nonverbal to verbal communication in children is signifi cantly infl uenced by the maternal secondary signaling system. Current geopolitical and health crises, such as the war in Ukraine and post- COVID-19 syndrome, exacerbate maternal stress and may aff ect mother- child interactions and child development.Aim. The purpose of this study is to examine diff erences in the activity of the second signaling system between mothers who report diffi culties perceiving their children and those who do not, and to understand the impact of these diff erences on motherchild interactions during the child’s verbal developmental period.Materials and methods. The study involved 184 mothers, divided into two groups: 98 mothers who reported diffi culties in perceiving their children and 86 mothers who did not. The The Questionnaire for Assessing the Activity of the Second Signal System (Language and Cognitive Test: How Well Do You Understand and Communicate?) (Lunov, 2023) was used to evaluate the activity of the second signal system across eight subscales corresponding to diff erent cytoarchitectonic fi elds. Independent samples t-tests were conducted to compare the mean scores of each subscale and the overall integral index between the groups. Results. Signifi cant diff erences were found on all subscales and the integral index, indicating notable discrepancies in the activity of the second signaling system between the two groups. Mothers who reported diffi culties had consistently lower scores, highlighting the need for targeted interventions to support their communication and interaction with their children. Discussion. The fi ndings highlight the critical role of the second signaling system in maternal perception and interaction. The combined eff ects of war-induced trauma and post- COVID-19 syndrome exacerbate these challenges and underscore the need for comprehensive support programs. Findings from studies underscore the importance of addressing transgenerational attachment factors and maternal mental health to improve mother- child relationships and promote healthy developmental outcomes.
ATTITUDES AND AWARENESS OF THE POPULATION OF CENTRAL AND WESTERN REGIONS OF UKRAINE TOWARDS VACCINATION
Authors: Nikitiuk S. , Hariian T. , Shkorbetska Y. , Pastushchyn V. 
Published: November 2024

In the modern world, vaccination is the most eff ective and evidence- based method of preventing the onset and severity of infectious diseases. Today, the WHO has identifi ed vaccine hesitancy as a global public health threat [25]. The social and cultural background of people infl uences their perception of vaccines, which prompted us to investigate this problem. Aim. To study the infl uence of sociodemographic factors on vaccination attitudes of children and adults in the central and western regions of Ukraine.Materials and methods. A cross- sectional study was conducted, which included a survey of the population of diff erent social status. The study was conducted in accordance with the tenets of the Declaration of Helsinki. The study protocol was approved by the bioethics committee. We also analyzed literature data from PubMed, Medscape and CSC. The work was performed within the framework of the research project 0122U000039 «Improvement of methods of diagnosis, treatment and rehabilitation of the most common diseases of childhood». No confl icts of interest exist.Research results and discussion. 1000 respondents were interviewed by questionnaire from Kyiv, Cherkasy, Kirovograd, Khmelnytsky, Zhytomyr, Chernivtsi, Ternopil, Rivne, Volyn, Ivano- Frankivsk, Lviv regions. The data obtained indicate that barriers to vaccination are caused by low awareness of vaccination, excessive negative infl uence of opinion leaders, prevalence of myths and falsifi cations about vaccination, lack of health care resources and low supply of recommended vaccines, and forced migration. Low awareness and low vaccination coverage are also associated with low awareness among health workers who do not work directly with vaccines, falsifi cation of vaccination data, and the presence of anti-vaccine health workers. The negative attitude of parents towards vaccination is also very important, as it aff ects their children.Conclusions.1. Fear of side eff ects, long-term complications, and doubts about the quality of vaccines have been identifi ed as factors in vaccine refusal.2. The most common groups of vaccine refusers are the elderly (53.3 %) and men (16.8 %).3. The high cost of vaccines that are not included in the list of mandatory vaccines is one of the reasons for the decrease in vaccination rates.4. Improved communication between the doctor and the patient is one of the factors increasing the vaccination rate among the population.5. Information about the availability of vaccines and places of vaccination, peculiarities of the post-vaccination period and information about the possible consequences of ignoring vaccination should be provided in the media (television, radio), especially among the elderly.
On Weak Solutions to Parabolic Problem Involving the Fractional p-Laplacian Via Young Measures
Authors: Talibi Ihya , Balaadich Farah , El Boukari Brahim , El Ghordaf Jalila 
Published: November 2024

Abstract
In this paper, we study the local existence of weak solutions for parabolic problem involving the fractional p-Laplacian. Our technique is based on the Galerkin method combined with the theory of Young measures. In addition, an example is given to illustrate the main results.
Pemasangan Dua Merek Implan pada Satu Pasien
Authors: Santoso Alice , Ariesanti Yessy 
Published: November 2024

Introduction: Dental implants have been used in dentistry for more than half a century and have a high success rate (90 - 95%). The number of implant patients has increased today and is expected to continue to increase for the next few years. Various studies have been conducted to find the best implant material. Titanium and its mixtures are still the material of choice for implants today. The author wants to present a case report of a 39-year-old man who underwent the installation of two implants in the mandibular region
Case Report: A 39-year-old man came in with a complaint of missing right and lower left back teeth since 7 years ago due to caries. The patient has a smoking habit. The patient is planned to undergo the implantation of 37 teeth with biotec BTK and 47 teeth with Straumann. The implant was well installed and no complications were found. Patients are asked to keep the implant area and oral cavity clean, as well as routinely check with the dentist every 6 months.
Discussion: Biotec implants (BTK) are implants made of pure titanium (Ti) grade 4 (ASTM F 67 / ISO 2832-2) while Straumann implants are made of Roxolid (85% titanium and 15% Zirconia [TiZr]).
Conclusion: Titanium Zirconium (TiZr) and pure Titanium are the preferred materials in the field of implants. Both can be well integrated and are able to restore optimal chewing function.
Increased caveolin 1 by human antigen R exacerbates Porphyromonas gingivali-induced atherosclerosis by modulating oxidative stress and inflammatory responses
Authors: Miao Fang , Lei Yangyang , Guo Yunfei , Ma Yongxia , Zhang Ye , Jia Binbin 
Published: November 2024

Objective:
Many different types of infectious oral diseases have been identified clinically, including chronic periodontitis. Porphyromonas gingivalis is the main pathogen causing chronic periodontitis, which is closely related to atherosclerosis (AS) and can promote the expression levels of caveolin 1 (Cav-1) and induced ribonucleic acid (RNA)-binding protein human antigen R (HuR). However, the roles of Cav-1 and its relationship with HuR in P. gingivalis-mediated AS progression remain largely unknown. Here, we aimed to detect the role and molecular mechanisms of Cav-1 in P. gingivalis-mediated AS.

Material and Methods:
To investigate the role of Cav-1 in P. gingivalis-mediated AS, we infected human umbilical vein endothelial cells (HUVECs) with P. gingivalis at a multiplicity of infection of 100:1 for 6, 12, and 24 h to simulate P. gingivalis-induced AS models in vitro and then transfected them with Cav-1 small interfering RNA to silence Cav-1. Combining molecular biology experimental techniques such as cell counting kit-8 assay, enzyme-linked immunosorbent assay, immunofluorescence staining, flow cytometry, Western blotting, and Oil Red O staining, and apolipoprotein E-deficient AS model mice, the impacts of Cav-1 on cell viability, inflammation, oxidative stress, apoptosis, Cav-1 and intercellular cell adhesion molecule-1 (ICAM-1) levels, and atherosclerotic plaque formation were investigated. Then, the relationship between Cav-1 and HuR was investigated through biotin pull-down and RNA immunoprecipitation assays, reverse transcription quantitative polymerase chain reaction, and Western blot.

Results:
P. gingivalis can induce Cav-1 expression in a time- and dose-dependent manner (P < 0.05). This effect can inhibit the proliferation of HUVECs (P < 0.05). Cav-1 interference repressed inflammatory response, reactive oxygen species (ROS) and ICAM-1 levels, and apoptosis in the HUVECs (P < 0.05). Cav-1 messenger RNA was stabilized by HuR, which can bind to the 3’ untranslated region of Cav-1. Increase in HuR level reversed the effects of Cav-1 silencing on ROS and ICAM-1 levels and apoptosis in the HUVECs (P < 0.05). In addition, the levels of inflammatory response, oxidative stress, and atherosclerotic plaque formation induced by P. gingivalis in the mouse model were significantly reduced after Cav-1 expression was inhibited (P < 0.05).

Conclusion:
HuR-activated Cav-1 may promote atherosclerotic plaque formation by modulating inflammatory response and oxidative stress, leading to AS.
Effect of the COVID-19 vaccination on feto-maternal outcomes: A prospective cohort study among Indian pregnant women
Authors: Gandhi Aravind P. , Thakur JS , Gupta Madhu , Soundappan Kathirvel , Goel Kapil , Singh Gopal , Singh Tarundeep 
Published: November 2024

Background & objectives
Studies on the effects of COVID-19 vaccination among pregnant women in Asian settings, more specifically in India, are scarce. The present study evaluated the feto-maternal outcomes among Indian pregnant women who received the COVID-19 vaccine.

Methods
A prospective cohort study was undertaken among 430 pregnant women from two primary health centres (PHC) in Chandigarh, India during 2021-2022. The feto-maternal outcomes evaluated in the study included abortions, live birth/stillbirth, term/pre-term/post-term delivery, mode of delivery (normal vaginal/caesarean section/forceps), birth weight and intrauterine growth retardation.

Results
Of the 430 study participants, 295 pregnant women received COVID-19 vaccines, with an uptake rate of 68.6 per cent. Majority of vaccinated women (280- who completed the study) were in their second trimester (133, 47.5%), while 92 (32.9%) were in their third, and 55 (19.6%) were in their first trimester when they were enrolled in the study. Neonatal intensive care unit (NICU) admission was significantly lower among the vaccinated pregnant women, while other feto-maternal and neonatal outcomes were similar between vaccinated and unvaccinated pregnant women.

Interpretation & conclusions
The findings of this study suggest COVID-19 vaccination in pregnant women in India might be safe, in terms of feto-maternal outcomes
Evaluation of rate and severity of COVID-19 infection after vaccination in the age group of 18–25-year population: A questionnaire-based study
Authors: Nikam Dipali Shantaram , Dahivelkar SachinKumar Dattatray , Mali Shrikant 
Published: November 2024

Objectives:
Covid-19 has been a challenging and challenging pandemic for mankind, with the introduction of the novel coronavirus, SARSCov-2, in late December 2019. Vaccination has proven to be a boon in these challenging times, with the study aiming to determine the efficacy of vaccination against the novel coronavirus in terms of the number of cases affected before and after vaccination and the severity of illness in post-vaccinated Covid-affected individuals. The study aims to learn from the lessons learned during this challenging period.

Material and Methods:
Students between age group of 18 to 25, from Nashik District, Maharashtra State, India, were the subject of a questionnaire-based study. Using Google Form, a survey was created.

Results:
It was found that vaccination has reduced the number of positive Covid 19 cases and we have seen a statistically significant decrease in the number of Covid-19-affected individuals.

Conclusion:
In the present study, we found that the severity is reduced and a smaller number of severe cases are seen after vaccination however the sample was small so this finding was not statically significant.
Patient-related perceptions and experience measures of non-surgical endodontic treatment – A cross-sectional study
Authors: Harshavardhan Lalam , Swapna Sannapureddy , Keerthana Laddagiri Nagamuni , Reddy Chennuru Sashibharath Kumar , Suneelkumar Chinni , Govula Kiranmayi , Lavanya Anumula 
Published: November 2024

Objectives:
This study assessed the outpatients’ perceptions of non-surgical root canal treatment (RCT) and compared them with their post-treatment experiences.

Material and Methods:
Eighty participants were selected for this cross-sectional study based on inclusion and exclusion criteria. Two surveys were conducted from October 01, 2023, to November 30, 2023 (Pretreatment survey) – one conducted before the RCT includes a survey about the patient’s past RCT experiences and demographics such as age, sex, and level of educational status. Multiple-choice questions were employed to determine patient concerns related to RCT, while modified visual analog scales (0–100) were used to assess pain and anxiety (Post-treatment survey) – done after the endodontic procedure with a root canal filling material. It outlines the patient’s experience, any discomfort experienced during treatment, the significance of tooth retention, and Re-RCT.

Results:
No difference was found in the demographic analysis. Out of the 80 participants, 33 participants (41.25%) presented with pretreatment anxiety, and 12 participants (15%) reported post-treatment. In the pretreatment survey, the primary concerns were pain and cost, which were reported at 27.55% and 10%, respectively. The post-treatment survey detailed that the time and the need for Re-RCT were the concerns, with reported rates of 11.25% and 10%, respectively. An absolute difference was found between anticipated and pre-operative pain and between experienced and pre-operative pain. However, no difference was found between anticipated and experienced pain 89% of the patients were willing to go for RCT again if needed.

Conclusion:
Treatment success is the goal for any dental procedure performed, which might be perceived differently by the patient and dentist. Consideration of patient perceptions and experiences, along with the dentist’s opinions, will help enhance endodontic treatment success.
Neuroepithelial cyst causing homonymous hemianopia treated through surgical marsupialization under visual-evoked potentials: A case report
Authors: Hernandez Lucas Miguel , Chisvo Nathan , Chan Abigail , O’Neill Kevin , Anichini Giulio 
Published: November 2024

Background:
Neuroepithelial cysts (NECs) are rare entities, occasionally causing neurological symptoms that can be overlooked.

Case Description:
A case of an occipital neuroepithelial cyst is discussed. The initial presentation consisted of mild homonymous hemianopia and gait impairment. Conservative management was suggested to start with, but at 6 months follow-up, the patient’s symptoms were worsening. Surgery was performed under general anesthetic and using visual-evoked potentials. The cyst was marsupialized and connected with subdural space, and a few samples were sent for histological analysis. The patient experienced immediate improvement in her symptoms, and the visual tests at follow-up confirmed the resolution of the previously documented hemianopia.

Conclusion:
NECs should be carefully assessed to rule out symptoms associated with mass effects. This case and others reported in the international literature show that occipital neuroepithelial cysts can benefit from surgical treatment with meticulous preoperative planning. The aid of neuromonitoring is crucial to identify anatomical variations and cortical functionality that are potentially distorted in the presence of these lesions.
Endovascular treatment for posterior inferior cerebellar artery aneurysm with vertebral artery stenosis: The critical role of diagnosing osteophyte compression
Authors: Isoda Masanori , Iida Yu , Akimoto Taisuke , Hori Satoshi , Suenaga Jun , Shimizu Nobuyuki , Nakai Yasunobu , Yamamoto Tetsuya 
Published: November 2024

Background:Vertebral artery (VA) stenosis can be caused by several factors, including arteriosclerosis, arterial dissection, and mechanical compression. Symptomatic vertebrobasilar insufficiency caused by VA stenosis due to mechanical compression associated with head rotation is well-known as Bow Hunter’s syndrome. However, an accurate diagnosis of asymptomatic osteophyte compression-induced nonrotational VA stenosis is difficult. We report a case of left posterior inferior cerebellar artery aneurysm with severe left VA stenosis, treated with stent-assisted coil embolization following appropriate diagnosis.Case Description:A 72-year-old female patient was found to have severe asymptomatic VA stenosis at the V2 segment (C4–5 level of the cervical spine) on cerebral angiography. Osteophyte compression-induced VA stenosis was suspected, which was confirmed by cone-beam computed tomography. The VA stenosis improved by flexing the neck and fixing the head position, following which the endovascular treatment was successfully completed.Conclusion:The site of the VA stenosis is critical in determining the etiology. Atherosclerotic VA stenosis often occurs at the origin of the artery or V4 segment, whereas bony compression-induced stenosis is more likely to occur at the V2 segment. Diagnosis and appropriate management of VA stenosis is based on determining the site.