bluuebunny/crossref_metadata_2025_split huggingface dataset:
Los impactos del turismo en España: diferencias entre destinos de sol y playa y destinos de interior
Authors: Gómez Bruna Diana , Martín Duque Clara 
Published: May 2019

El presente artículo tiene como objetivo la evaluación de los impactos económicos, socioculturales y medioambientales ocasionados por el turismo en España. En concreto, el artículo mide la percepción que de ellos tienen los residentes de 151 municipios turísticos valorando las posibles diferencias entre las percepciones de los residentes de destinos de sol y playa y de interior. Para ello, se han realizado 1027 encuestas analizadas a través de la prueba paramétrica para la comparación de medias (ANOVA). Este análisis ha permitido determinar, entre otras cuestiones, que los residentes de los destinos de sol y playa perciben los impactos del turismo de forma más negativa que los de los destinos de interior.
This article aims to evaluate the perception of the Spanish residents about the economic, sociocultural and environmental impacts that tourism generate in Spain. In particular, the article analyse the resident percepcion of the impacts in 151 spanish destinations making distinctions between coastal destinations and hinterland destinations. To this end we have made a one way ANOVA based on 1027 surveys. This analysis of the data shows that those resident who live in coastal areas perceive more strongly the negatives effects of tourism than those who live in hinterlands.
Salta (Argentina) como ciudad patrimonial y cosmopolita: la definición de un destino turístico “competitivo”
Authors: Troncoso Claudia Alejandra 
Published: May 2019

El presente trabajo aborda los procesos de transformación reciente de Salta (Argentina), ciudad que se ha definido en las últimas décadas como un importante destino turístico en el contexto nacional. En años recientes, desde el gobierno provincial (con colaboración de empresarios y expertos), se gestó un proyecto de renovación del área histórica orientado a estimular la llegada de turista que acentuó el carácter patrimonial de la ciudad pero también buscó definirla como una ciudad cosmopolita. Como parte de este proceso, el centro histórico se perfiló como un espacio de consumo turístico que también atrajo a ciertos sectores de la sociedad local.
The paper deals with the recent processes that have transformed Salta into an important tourist destination in Argentina. In the last decades, provincial government (together with entrepreneurial actors and cultural and scientific experts) has launched an urban renewal program to revitalize the historic district and improve infrastructures to stimulate tourism. This reinforced the heritage aspects of Salta but also sought to show it as a cosmopolitan city. As part of this process historic district has become a space of consumption for tourist and privileged local society.
« La seule constance… c’est l’inconstance »
Authors: MacKenzie1 Kaitlin , Dubois Florence 
Published: May 2019

La présente étude se penche sur l’expérience d’individus qui visitent leurs proches dans les pénitenciers fédéraux au Canada, notamment sur les répercussions de l’utilisation d’un appareil de détection de drogues, le scanneur à ions, qui sert d’étape de contrôle des visiteurs des détenus. À partir de données tirées de huit entretiens non dirigés avec des personnes ayant connu des faux positifs sur le scanneur à ions lors de visites en prison, j’étudie les conséquences négatives de ce type de résultats, qui peuvent être assez fréquents, sur la vie des détenus et de leur famille. Même s’ils sont présentés comme des instruments objectifs et non biaisés, la manière dont les scanneurs à ions sont utilisés est empreinte de jugements moraux envers les individus qui visitent leurs proches détenus. J’aborde deux thèmes tirés de l’analyse : l’interaction entre le personnel carcéral et les familles des prisonniers ainsi que l’irrégularité et l’imprévisibilité des scanneurs à ions. L’analyse montre qu’il s’agit d’une technologie à risque d’erreurs qui participe à la stigmatisation – et même à la punition – des familles des détenus. En m’appuyant sur la littérature portant sur les conséquences collatérales de l’incarcération et sur les technologies du risque et de surveillance, je réfléchis à la manière dont les scanneurs à ions participent à l’extension des souffrances de l’incarcération aux visites en prison.
Quines normes? Una aproximació al debat sobre el concepte de malaltia mental
Authors: Ballesteros Virginia 
Published: May 2019

Which norms? An approach to the debate on the concept of mental illness

Resum: En aquest article realitzem una aproximació al debat sobre el concepte de malaltia mental, des dels anys cinquanta fins al present, incorporant-hi elements de la filosofia i sociologia de la medicina, i atenent a les seues dimensions orgànica, subjectiva i social. Perfilem i avaluem les postures naturalistes i normativistes que han conformat el debat sobre la malaltia mental: des de l’antipsiquiatria a la psiquiatria crítica, passant per un naturalisme i construccionisme social forts.
Paraules clau: malaltia mental, naturalisme, construccionisme, antipsiquiatria, psiquiatria crítica.

Abstract: In this paper we approach the debate on the concept of mental illness from the 1950s to the present, by incorporating elements from the philosophy and sociology of medicine, considering its bodily, subjective, and social dimensions. We outline and evaluate the naturalist and normativist views that have shaped the debate on mental illness: from antipsychiatry to critical psychiatry, passing through strong naturalism and social constructionism.
Keywords: mental illness, naturalism, constructionism, antipsychiatry, critical psychiatry.
Some Suggestions for Teaching Undergraduate Business Statistics Courses
Authors: Egodawatte Gunawardena 
Published: May 2019

Student anxiety is high in many business statistics courses. Often, students fail in these courses because they rely highly on grades rather than on meaningful learning. Instructors also feel the pressure because their students do not attempt to learn deeply. I taught Quantitative Methods courses for a number of years in a University in Ontario, Canada. In this paper, I have critically analyzed some of the challenges that instructors face in teaching these courses and suggested some solutions based on an educational point of view. Continuous assessment, portfolio construction, and improving the efficiency of instructor evaluations are three key suggestions for consideration.
As these challenges are common to most undergraduate courses in business statistics, the suggestions would mainly help to raise student motivation, encourage students to learn deeply, and increase instructor efficiency.
Development of a rotational set‐up correction device for stereotactic head radiation therapy: A performance evaluation
Authors: Usui Keisuke , Isobe Akira , Hara Naoya , Muroi Tomoya , Sajiki Osamu , Ogawa Koichi , Shikama Naoto , Sasai Keisuke 
Published: May 2019

AbstractWe developed a new head supporting device to provide accurate correction of rotational setup during image‐guided radiation therapy (IGRT), evaluating its correction performance and the efficacy of dose distribution in stereotactic radiotherapy (SRT) using a helical tomotherapy (HT) system. The accuracy of rotational motion was measured using an electronic inclinometer; we compared device angles and measurement values from 0.0° to 3.0°. The correction accuracy was investigated based on the distance between rotational centers in the device and on megavoltage computed tomography (MVCT); the correction values were compared using distances in the range of 0.0–9.0 cm using a head phantom with a rotational error of 1.5°. For an SRT with a simultaneous integrated boost plan and a rotational error of 3.0° in yaw angle using a head phantom, and for a single‐isocenter SRT for multiple brain metastases in the data of three patients, dosimetric efficacy of the HT unit was evaluated for calculated dose distributions with MVCT after rotational correction. This device can correct pitch and yaw angles within 0.3° and can be corrected to within 0.5° for each rotational angle according to the result of MVCT correction regardless of the rotational center position. In the head phantom study, the device had a beneficial impact on rotational correction; D99% for the target improved by approximately 10% with rotational correction. Using patient data with the device, the mean difference based on the treatment planning data was 0.3% for D99% and −0.1% for coverage index to the target. Our rotational setup correction device has high efficacy, and can be used for IGRT.
Dosimetric comparison of distal esophageal carcinoma plans for patients treated with small‐spot intensity‐modulated proton versus volumetric‐modulated arc therapies
Authors: Liu Chenbin , Bhangoo Ronik S. , Sio Terence T. , Yu Nathan Y. , Shan Jie , Chiang Jennifer S. , Ding Julia X. , Rule William G. , Korte Shawn , Lara Pedro , Ding Xiaoning , Bues Martin , Hu Yanle , DeWees Todd , Ashman Jonathan B. , Liu Wei 
Published: May 2019

BackgroundEsophageal carcinoma is the eighth most common cancer in the world. Volumetric‐modulated arc therapy (VMAT) is widely used to treat distal esophageal carcinoma due to high conformality to the target and good sparing of organs at risk (OAR). It is not clear if small‐spot intensity‐modulated proton therapy (IMPT) demonstrates a dosimetric advantage over VMAT. In this study, we compared dosimetric performance of VMAT and small‐spot IMPT for distal esophageal carcinoma in terms of plan quality, plan robustness, and interplay effects.Methods35 distal esophageal carcinoma patients were retrospectively reviewed; 19 patients received small‐spot IMPT and the remaining 16 of them received VMAT. Both plans were generated by delivering prescription doses to clinical target volumes (CTVs) on phase‐averaged 4D‐CT's. The dose‐volume‐histogram (DVH) band method was used to quantify plan robustness. Software was developed to evaluate interplay effects with randomized starting phases for each field per fraction. DVH indices were compared using Wilcoxon rank‐sum test. For fair comparison, all the treatment plans were normalized to have the same CTVhigh D95% in the nominal scenario relative to the prescription dose.ResultsIn the nominal scenario, small‐spot IMPT delivered statistically significantly lower liver Dmean and V30Gy[RBE], lung Dmean, heart Dmean compared with VMAT. CTVhigh dose homogeneity and protection of other OARs were comparable between the two treatments. In terms of plan robustness, the IMPT and VMAT plans were comparable for kidney V18Gy[RBE], liver V30Gy[RBE], stomach V45Gy[RBE], lung Dmean, V5Gy[RBE], and V20Gy[RBE], cord Dmax and , liver Dmean, heart V20Gy[RBE], and V30Gy[RBE], but IMPT was significantly worse for CTVhigh D95%, , and D5%‐D95%, CTVlow D95%, heart Dmean, and V40Gy[RBE], requiring careful and experienced adjustments during the planning process and robustness considerations. The small‐spot IMPT plans still met the standard clinical requirements after interplay effects were considered.ConclusionsSmall‐spot IMPT decreases doses to heart, liver, and total lung compared to VMAT as well as achieves clinically acceptable plan robustness. Our study supports the use of small‐spot IMPT for the treatment of distal esophageal carcinoma.
Treatment Strategies in Early Rheumatoid Arthritis Methotrexate Management: Results From a Prospective Cohort
Authors: Moura Cristiano S. , Schieir Orit , Valois Marie‐France , Thorne Carter , Bartlett Susan J. , Pope Janet E. , Hitchon Carol A. , Boire Gilles , Haraoui Boulos , Hazlewood Glen S. , Keystone Edward C. , Tin Diane , Bykerk Vivian P. , Bernatsky Sasha ,   the Canadian Early Arthritis Cohort Investigators
Published: May 2019

ObjectiveTo assess real‐world practice patterns surrounding treatment initiation and adjustments over time for methotrexate (MTX) and non‐MTX–based treatment strategies in early rheumatoid arthritis (RA).MethodsWe studied a multicenter, incident early RA cohort (enrolled 2007–2017 within 1 year of symptoms) who fulfilled American College of Rheumatology/European League Against Rheumatism criteria. Adult patients with RA were eligible if treatment with MTX (± other disease‐modifying antirheumatic drugs [DMARDs]) was initiated within 90 days of cohort entry. We compared time until treatment change for 4 initial MTX‐based therapies and time to second treatment change after the first change. The definition of treatment change included changing of route for MTX monotherapy, adding or stopping a DMARD or biologic, and changing dose/frequency of a DMARD or biologic.ResultsThere was great variability of treatment at initiation and during therapy adjustment. In 1,484 patients with early RA, the majority initiated MTX monotherapy (oral or subcutaneous [SC]). Patients receiving SC MTX monotherapy changed treatment less (45% versus 79%) and remained on treatment longer (hazard ratio [HR] 0.52 [95% confidence interval (95% CI) 0.4–0.67]) than those receiving oral MTX monotherapy. Most therapy adjustments involved adding a DMARD or changing to a non‐MTX DMARD. Those adults taking biologics and who were receiving triple therapy had a longer time without treatment change (HR 0.26 [95% CI 0.16–0.42] and HR 0.57 [95% CI 0.38–0.85], respectively).ConclusionWe found large variability in the way MTX‐based therapies are prescribed in clinical practice. Our findings support the use of SC MTX monotherapy or MTX combination as initial therapy. For subsequent treatment after initial MTX‐based therapy, those patients initiating either biologics or triple therapy had a longer time to treatment change than oral MTX monotherapy.
Changes in Lipid Levels and Incidence of Cardiovascular Events Following Tofacitinib Treatment in Patients With Psoriatic Arthritis: A Pooled Analysis Across Phase III and Long‐Term Extension Studies
Authors: Gladman Dafna D. , Charles‐Schoeman Christina , McInnes Iain B. , Veale Douglas J. , Thiers Bruce , Nurmohamed Mike , Graham Dani , Wang Cunshan , Jones Thomas , Wolk Robert , DeMasi Ryan 
Published: May 2019

ObjectiveThe risk of cardiovascular disease (CVD) is higher in patients with psoriatic arthritis (PsA) compared to the general population. Tofacitinib is an oral Janus kinase inhibitor for the treatment of PsA. Because tofacitinib increases circulating lipid levels in some patients, we evaluated CVD risk factors and major adverse cardiovascular events (MACE) in patients with active PsA receiving tofacitinib 5 or 10 mg twice daily plus conventional synthetic disease‐modifying antirheumatic drugs.MethodsData were pooled from 2 phase III studies (Efficacy and Safety of Tofacitinib in Psoriatic Arthritis [OPAL Broaden] and Tofacitinib in Patients with Psoriatic Arthritis With Inadequate Response to TNF Inhibitors [OPAL Beyond]) and 1 ongoing long‐term extension (Open‐Label Extension Study of Tofacitinib in Psoriatic Arthritis [OPAL Balance], data cutoff January 2017; database not locked). Outcomes included fasting lipid levels, blood pressure, hypertension‐related adverse events (AEs; including hypertension, high blood pressure, and increased blood pressure), and MACE.ResultsOverall, 783 tofacitinib‐treated patients were included. Percentage increases from baseline in low‐density lipoprotein cholesterol (LDL‐c) and high‐density lipoprotein cholesterol (HDL‐c) levels ranged from 9% to 14% for tofacitinib 5 mg and 10 mg at 3 and 6 months; no meaningful changes in LDL‐c:HDL‐c or total cholesterol:HDL‐c ratios were observed. Blood pressure remained stable for 24 months. Fifty‐eight patients (7.4%) had hypertension‐related AEs; none were fatal (incidence rate [IR] per 100 patient‐years 4.81 [95% confidence interval (95% CI) 3.65–6.22]). Five patients (0.6%) had MACE (IR 0.24 [95% CI 0.05–0.70]); 2 were fatal.ConclusionSerum lipid level increases at month 3 following tofacitinib treatment in PsA were consistent with observations in rheumatoid arthritis and psoriasis. The IR of hypertension‐related AEs and MACE was low; long‐term follow‐up is ongoing.
Dissipative Catalysis with a Molecular Machine
Authors: Biagini Chiara , Fielden Stephen D. P. , Leigh David A. , Schaufelberger Fredrik , Di Stefano Stefano , Thomas Dean 
Published: May 2019

AbstractWe report on catalysis by a fuel‐induced transient state of a synthetic molecular machine. A [2]rotaxane molecular shuttle containing secondary ammonium/amine and thiourea stations is converted between catalytically inactive and active states by pulses of a chemical fuel (trichloroacetic acid), which is itself decomposed by the machine and/or the presence of additional base. The ON‐state of the rotaxane catalyzes the reduction of a nitrostyrene by transfer hydrogenation. By varying the amount of fuel added, the lifetime of the rotaxane ON‐state can be regulated and temporal control of catalysis achieved. The system can be pulsed with chemical fuel several times in succession, with each pulse activating catalysis for a time period determined by the amount of fuel added. Dissipative catalysis by synthetic molecular machines has implications for the future design of networks that feature communication and signaling between the components.
Distributed optimization for economic power dispatch with event‐triggered communication
Authors: Shi Xiasheng , Zheng Ronghao , Lin Zhiyun , Yan Gangfeng 
Published: May 2019

AbstractThis paper focuses on the economic power dispatch problem in a smart grid by using the distributed consensus with event‐triggered communication mechanism based on continuous‐time multi‐agent systems over balanced directed networks, where there are many generation units working cooperatively to achieve an optimal solution. The event‐triggered communication mechanism means that the information transmission between agents is triggered by event instead of time. The triggering condition and algorithm for each agent are fully decentralized. At each instant time, each agent updates its state by employing the states collected from itself and its neighboring agents at their last triggering time. Finally, two examples are given to analyze the feasibility of above proposed algorithm.
Improving the accuracy of flux balance analysis through the implementation of carbon availability constraints for intracellular reactions
Authors: Lularevic Maximilian , Racher Andrew J. , Jaques Colin , Kiparissides Alexandros 
Published: May 2019

AbstractConstraint‐based modeling methods, such as Flux Balance Analysis (FBA), have been extensively used to decipher complex, information rich ‐omics datasets to elicit system‐wide behavioral patterns of cellular metabolism. FBA has been successfully used to gain insight in a wide range of applications, such as range of substrate utilization, product yields and to design metabolic engineering strategies to improve bioprocess performance. A well‐known challenge associated with large genome‐scale metabolic networks is that they result in underdetermined problem formulations. Consequently, rather than unique solutions, FBA and related methods examine ranges of reaction flux values that are consistent with the studied physiological conditions. The wider the reported flux ranges, the higher the uncertainty in the determination of basic reaction properties, limiting interpretability of and confidence in the results. Herein, we propose a new, computationally efficient approach that refines flux range predictions by constraining reaction fluxes on the basis of the elemental balance of carbon. We compared carbon constraint FBA (ccFBA) against experimentally‐measured intracellular fluxes using the latest CHO GEM (iCHO1766) and were able to substantially improve the accuracy of predicted flux values compared with FBA. ccFBA can be used as a stand‐alone method but is also compatible with and complimentary to other constraint‐based approaches.
Legal perspectives on black box recording devices in the operating environment
Authors: Dalen A S H M , Legemaate J , Schlack W S , Legemate D A , Schijven M P 
Published: May 2019

AbstractBackgroundA video and medical data recorder in the operating theatre is possible, but concerns over privacy, data use and litigation have limited widespread implementation. The literature on legal considerations and challenges to overcome, and guidelines related to use of data recording in the surgical environment, are presented in this narrative review.MethodsA review of PubMed and Embase databases and Cochrane Library was undertaken. International jurisprudence on the topic was searched. Practice recommendations and legal perspectives were acquired based on experience with implementation and use of a video and medical data recorder in the operating theatre.ResultsAfter removing duplicates, 116 citations were retrieved and abstracts screened; 31 articles were assessed for eligibility and 20 papers were finally included. According to the European General Data Protection Regulation and US Health Insurance Portability and Accountability Act, researchers are required to make sure that personal data collected from patients and healthcare professionals are used fairly and lawfully, for limited and specifically stated purposes, in an adequate and relevant manner, kept safe and secure, and stored for no longer than is absolutely necessary. Data collected for the sole purpose of healthcare quality improvement are not required to be added to the patient's medical record.ConclusionTransparency on the use and purpose of recorded data should be ensured to both staff and patients. The recorded video data do not need to be used as evidence in court if patient medical records are well maintained. Clear legislation on data responsibility is needed to use the medical recorder optimally for quality improvement initiatives.