bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Thiazolo[3,2‐b] [1,2,4]triazoles through Pd‐Catalyzed Copper‐Free Sonogashira Coupling Reaction
Authors: Bakherad Mohammad , Kakav Ghalenoei Ahmad , Keivanloo Ali 
Published: August 2019

AbstractThe synthesis of 2‐substituted thiazolo[3,2‐b] [1,2,4]triazoles is accomplished copper‐free, Pd‐catalyzed Sonogashira reaction of 6‐(iodomethyl)‐2‐methylthiazolo[3,2‐b][1,2,4]triazole with terminal alkynes in DMF at 70 °C. The coupling reaction of phenylacetylene and 4‐ethynyltoluene gave the desired products in high yields. While, the Sonogashira reaction of alkynes such as 1‐hexyne, 1‐octyne, propargyl alcohols, and propargyl amines afforded the products in good yields.
Reactive behavioural adaptation of service compositions
Authors: Tretola Giancarlo , Zimeo Eugenio 
Published: August 2019

AbstractWe are assisting to a paradigmatic shift in developing Web applications since their components are often distributed and deployed as services among different organizations. Their logic is based on a set of actions that can be linked together by exploiting higher level languages more suitable to address the scale of the Web. On this multi‐organization scale, applications can be influenced by different context events generated by the environment where they run. Handling these events requires run‐time adaptations of the application's behaviour to react, properly and quickly, to changes. The paper addresses these needs by proposing a programming paradigm based on “autonomic service compositions,” ie, compositions that are able to self‐change their structure, according to a specific life cycle, to allow for the continuation of execution, even if unexpected events arise. The approach exploits autonomic computing and reasoning for taking decision on information collected during processes execution. Autonomic actions on composition structures are performed using Event Condition Action rules and a set of meta‐operations. The approach is detailed, analysed, and discussed with reference to some examples derived from a real‐world application.
Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy
Authors: Liao Jinfeng , Jia Yanpeng , Wu Yongzhi , Shi Kun , Yang Dawei , Li Pei , Qian Zhiyong 
Published: August 2019

AbstractCancer therapy is unsatisfactory as it typically has serious side effects, because normal cells in healthy organs are destroyed along with the tumor. Thus, researchers have tried to develop effective therapies with minimal side effects. One such method is to use nanotechnology to carry the drugs or therapeutic agents to the tumor region by secure encapsulation without leakage. Once the nanomedicine enters the target tumor site, it can release therapeutic agents in an effective manner. Accordingly, various nanomedicines have been developed to enhance the efficiency of cancer therapy and minimize the systematic toxicity. Here, we provide an overview and discuss the different types of responsive nanomedicines including physically, chemically, biologically, dual, and multi‐responsive nanomedicines, for the in situ release of cargos in recent years. We propose critical considerations that must be considered for the design of excellent stimuli‐nanomedicine. Furthermore, the possible directions for the development of successful stimuli‐responsive (smart) nanomedicine are highlighted. With the development of responsive nanomedicines, precise and personalized nanomedicine will be realized with great promise in the future.This article is categorized under:Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic DiseaseNanotechnology Approaches to Biology > Nanoscale Systems in Biology
Composing Proof Terms
Authors: Kohl Christina , Middeldorp Aart 
Published: August 2019

AbstractProof terms are a useful concept for comparing computations in term rewriting. We analyze proof terms with composition, with an eye towards automation. We revisit permutation equivalence and projection equivalence, two key notions presented in the literature. We report on the integration of proof terms with composition into ProTeM, a tool for manipulating proof terms.
Characterization of the microbiota in long- and short-term natural indigo fermentation
Authors: Tu Zhihao , de Fátima Silva Lopes Helena , Igarashi Kensuke , Yumoto Isao 
Published: August 2019

Abstract
The duration for which the indigo-reducing state maintenance in indigo natural fermentation in batch dependent. The microbiota was analyzed in two batches of sukumo fermentation fluids that lasted for different durations (Batch 1: less than 2 months; Batch 2: nearly 1 year) to understand the mechanisms underlying the sustainability and deterioration of this natural fermentation process. The transformation of the microbiota suggested that the deterioration of the fermentation fluid is associated with the relative abundance of Alcaligenaceae. Principal coordinates analysis (PCoA) showed that the microbial community maintained a very stable state in only the long-term Batch 2. Therefore, entry of the microbiota into a stable state under alkaline anaerobic condition is an important factor for maintenance of indigo fermentation for long duration. This is the first report on the total transformation of the microbiota for investigation of long-term maintenance mechanisms and to address the problem of deterioration in indigo fermentation.
Influence of Alcohol on Phosphodiesterase 5 inhibitors Use in Middle- to Old-Aged Men: A Comparative Study of Adverse Events
Authors: Kim Jong Nyeong , Oh Jong Jin , Park Dong Soo , Hong Young Kwon , Yu Young Dong 
Published: August 2019

Abstract

Introduction
Some previous studies reported recreational use of phosphodiesterase type 5 (PDE-5) inhibitors by ingesting the medicine with alcohol in patients with erectile dysfunction, but the rate of misuse in general population has never been researched.

Aim
To investigate the frequency of concomitant alcohol consumption with PDE-5 inhibitors in the general male population. We secondarily analyzed the influence of alcohol on PDE-5 inhibitor.

Methods
325 men with erectile dysfunction (age 34–78) who received PDE-5 inhibitors at a single medical institution from January 2016–February 2018 were included in the study. All patients fulfilled a survey questionnaire assessing (i) average alcohol consumption amount, (ii) previous use of PDE-5 inhibitors with alcohol and purpose of concomitant alcohol use, (iii) and background knowledge about PDE-5 inhibitors' side effects.

Main Outcomes Measures
The main outcome measure was frequency of concomitant alcohol consumption with PDE-5 inhibitors in the general male population.

Results
Overall 148 patients committed concomitant alcohol use (group 1), and 177 patients did not (group 2). No significant differences were observed between 2 groups regarding types of PDE-5 inhibitors used and underlying disease. Group 2 had significantly more patients with the correct knowledge concerning concomitant alcohol use than group 1 (24.9% vs 13.5%). Group 1 had more patients with average alcohol consumption &gt;15 drinks/week (64.8% vs 14.1%). The reasons for concomitant alcohol use were curiosity (35.1%), enhancing sexual desire (27%) and recommendation from friends (16.9%). Group 1 showed significantly greater complications, including headache (23.6% vs 7.3%) and facial flushing (69.6% vs 12.4%), than group 2. 1 patient in group 1 experienced severe chest discomfort and underwent coronary artery angiography, but no severe obstructive lesion was observed.

Conclusion
45.5% of middle- to old-age men committed concomitant use of PDE-5 inhibitor with alcohol because of recreational purpose, and this alcohol abuse might lead to severe complications, including chest discomfort and dizziness.
LARGE CARDINALS BEYOND CHOICE
Authors: BAGARIA JOAN , KOELLNER PETER , WOODIN W. HUGH 
Published: August 2019

AbstractThe HOD Dichotomy Theorem states that if there is an extendible cardinal, δ, then either HOD is “close” to V (in the sense that it correctly computes successors of singular cardinals greater than δ) or HOD is “far” from V (in the sense that all regular cardinals greater than or equal to δ are measurable in HOD). The question is whether the future will lead to the first or the second side of the dichotomy. Is HOD “close” to V, or “far” from V? There is a program aimed at establishing the first alternative—the “close” side of the HOD Dichotomy. This is the program of inner model theory. In recent years the third author has provided evidence that there is an ultimate inner model—Ultimate-L—and he has isolated a natural conjecture associated with the model—the Ultimate-L Conjecture. This conjecture implies that (assuming the existence of an extendible cardinal) that the first alternative holds—HOD is “close” to V. This is the future in which pattern prevails. In this paper we introduce a very different program, one aimed at establishing the second alternative—the “far” side of the HOD Dichotomy. This is the program of large cardinals beyond choice. Kunen famously showed that if AC holds then there cannot be a Reinhardt cardinal. It has remained open whether Reinhardt cardinals are consistent in ZF alone. It turns out that there is an entire hierarchy of choiceless large cardinals of which Reinhardt cardinals are only the beginning, and, surprisingly, this hierarchy appears to be highly ordered and amenable to systematic investigation, as we shall show in this paper. The point is that if these choiceless large cardinals are consistent then the Ultimate-L Conjecture must fail. This is the future where chaos prevails.
An Approach to Legal Principles Based on Their Justifying Function
Authors: Etcheverry Juan B. 
Published: August 2019

AbstractThis paper intends to throw light upon some aspects of the debate on the characterization of legal principles and on their differences when compared to rules. Particularly, this analysis proposes differentiating principles from rules by considering the functions they perform in law instead of their structural differences. To achieve this, we distinguish between the functions of guidance and justification that legal principles fulfill. From that distinction, we observe that the attempt to characterize legal principles based on the way in which they guide conduct does not seem to be the most appropriate either. In contrast, this paper tries to show that all the different types of precepts known as principles perform a justifying function in legal reasoning.
Contemporary Tort Theory and Tort Law’s Evolution
Authors: Murphy John 
Published: August 2019

AbstractAlthough grand, explanatory theories of tort law come apart from one another in many ways, they also have a fair amount in common. One core claim found in the work of various Kantian theorists, as well as a number of leading rights theorists, is that tort law develops, incrementally, in such a way as to achieve ever greater coherence (where such coherence is measured according to key tenets of the particular theories). This article takes issue with that claim. It shows, by reference to a host of legal landmarks, that tort law neither does, nor must, develop in this way. A great many important innovations in tort cannot be reconciled with central aspects of the theories in view, but they are easily explained by reference to major changes in material conditions of life, shifts in the ideological Zeitgeist, judicial partiality and juristic influence. As long as such factors are free to exert their influence – and there is nothing to suggest that they are not so free – it is implausible to suggest that tort law will inexorably move towards a state of ever greater coherence.
Surgical site infections in outpatient surgeries: Less invasive procedures contribute substantially to the overall burden
Authors: Linsenmeyer Katherine , Branch-Elliman Westyn , Kalver Emily , Mull Hillary J. 
Published: August 2019

AbstractMore than 50% of outpatient surgeries predicted to have an increased likelihood of an adverse event were excluded from surgical site infection (SSI) surveillance based on Veterans Affairs Surgical Quality Improvement Program (VASQIP) eligibility criteria, defined by clinician determination of invasiveness. Burden of SSI for eligible versus ineligible surgeries was similar; thus, surveillance activities in the outpatient setting need to be re-evaluated.
A Low-cost Continuous-flow Gas Interface for Coupling an Elemental Analyzer with a Micadas AMS: gas flow Mathematical Model and first results
Authors: Salazar Gary , Szidat Sönke 
Published: August 2019

ABSTRACTA fully automatic continuous-flow gas injection interface was built to couple an elemental analyzer with a MICADAS accelerator mass spectrometer (AMS) as a low-cost option that does not require an absorber trap for CO2 injection. The complication of the variable ion current during gas injection can be overcome by understanding and controlling the mass flow-dependent ionization yield. The time-varying CO2 concentrations and carbon mass flows are estimated with a mathematical model in order to investigate their relationship with the abundant isotope (12C–) signal. This model is based on a complete CO2 diffusion equation and instantaneous mass flow. It shows a good agreement between model calculations and the measurements. A reversible suppression of the formation of ions occurs, if the carbon mass flow exceeds 2.0–2.3 µg C/min. This result repeats for different injection capillaries and for different carrier volumetric flow rates.
Enzymatically modified isoquercitrin improves endothelial function in volunteers at risk of cardiovascular disease
Authors: Bondonno Nicola P. , Bondonno Catherine P. , Ward Natalie C. , Woodman Richard J. , Hodgson Jonathan M. , Croft Kevin D. 
Published: August 2019

AbstractA higher intake of food rich in flavonoids such as quercetin can reduce the risk of CVD. Enzymatically modified isoquercitrin (EMIQ®) has a bioavailability 17-fold higher than quercetin aglycone and has shown potential CVD moderating effects in animal studies. The present study aimed to determine whether acute ingestion of EMIQ® improves endothelial function, blood pressure (BP) and cognitive function in human volunteers at risk of CVD. Twenty-five participants (twelve males and thirteen females) with at least one CVD risk factor completed this randomised, controlled, crossover study. In a random order, participants were given EMIQ® (2 mg aglycone equivalent)/kg body weight or placebo alongside a standard breakfast meal. Endothelial function, assessed by flow-mediated dilatation (FMD) of the brachial artery was measured before and 1·5 h after intervention. BP, arterial stiffness, cognitive function, BP during cognitive stress and measures of quercetin metabolites, oxidative stress and markers of nitric oxide (NO) production were assessed post-intervention. After adjustment for pre-treatment measurements and treatment order, EMIQ® treatment resulted in a significantly higher FMD response compared with the placebo (1·80 (95 % CI 0·23, 3·37) %; P = 0·025). Plasma concentrations of quercetin metabolites were significantly higher (P < 0·001) after EMIQ® treatment compared with the placebo. No changes in BP, arterial stiffness, cognitive function or biochemical parameters were observed. In this human intervention study, the acute administration of EMIQ® significantly increased circulating quercetin metabolites and improved endothelial function. Further clinical trials are required to assess whether health benefits are associated with long-term EMIQ® consumption.
THE POLITICS OF FILTH: SANITATION, WORK, AND COMPETING MORALITIES IN URBAN MADAGASCAR 1890s–1977
Authors: RIJKE-EPSTEIN TASHA 
Published: August 2019

ABSTRACTThis article tracks the historical processes that shaped human waste management practices in Majunga, Madagascar from the city's founding in the mid-eighteenth century to contemporary times. Moving beyond colonial urban histories of sanitation, this article charts the meanings, strategies, and work practices Majunga residents employed to deal with predicaments of waste in everyday life. I argue that the particular material configuration of the colonial sanitation infrastructure in Majunga required new forms of labor — especially maintenance work — which city dwellers evaluated through existing moral norms. With the construction of French colonial sanitation infrastructures and the new labor regimes they necessitated, waste management became a key vector through which notions of difference were negotiated over the early- to mid-twentieth century. Shifting emphasis away from colonial infrastructure as disparity and onto moments of reception can contribute fresh insights not only on the histories of African cities, but also to histories of technology in the Global South.
Hope in Dirt: Report of the Fort Apache Workshop on Forensic Sedimentology Applications to Cultural Property Crime, 15—19 October 2018
Authors: Welch John R. , Altaha Mark T. , Cantley Garry J. , Doelle William H. , Herr Sarah A. , Kersel Morag M. , MacDonald Brandi L. , McManamon Francis P. , Mills Barbara , Nials Fred , Ownby Mary , Richards Michael , Riley Ramon , Ryan Stacy L. , Whiting Duston , Yates Donna 
Published: August 2019

Summary:A 2018 workshop on the White Mountain Apache Tribe lands in Arizona examined ways to enhance investigations into cultural property crime (CPC) through applications of rapidly evolving methods from archaeological science. CPC (also looting, graverobbing) refers to unauthorized damage, removal, or trafficking in materials possessing blends of communal, aesthetic, and scientific values. The Fort Apache workshop integrated four generally partitioned domains of CPC expertise: (1) theories of perpetrators’ motivations and methods; (2) recommended practice in sustaining public and community opposition to CPC; (3) tactics and strategies for documenting, investigating, and prosecuting CPC; and (4) forensic sedimentology—uses of biophysical sciences to link sediments from implicated persons and objects to crime scenes. Forensic sedimentology served as the touchstone for dialogues among experts in criminology, archaeological sciences, law enforcement, and heritage stewardship. Field visits to CPC crime scenes and workshop deliberations identified pathways toward integrating CPC theory and practice with forensic sedimentology’s potent battery of analytic methods.
Derailing State Immunity: A Broad-Brush Approach to Jurisdiction under Claims for the Expropriation of Cultural Property
Authors: Tattersall Luke 
Published: August 2019

Abstract:The following article considers the approach taken by the courts of the United States in claims concerning issues of state immunity and private international law with respect to the expropriation and restitution of cultural property, primarily in the context of Nazi Germany. It can be seen that the US courts have interpreted the provisions under the Foreign Sovereign Immunities Act so as to significantly widen the scope for individuals to bring claims against states and state entities in circumstances where the case, and the property concerned, has little or no connection with the jurisdiction and which at their core are domestic disputes.
Detecting Heritage Crime(s): What We Know about Illicit Metal Detecting in England and Wales
Authors: Daubney Adam , Nicholas Louise E. 
Published: August 2019

Abstract:Metal detecting is a popular hobby in England and Wales, and, since 1997, over 1.3 million finds have been recorded by the Portable Antiquities Scheme (PAS), a scheme to encourage the voluntary recording of artifacts found by the public. The metal detector can be a useful archaeological tool when used lawfully and responsibly; however, it is also a tool that is used for illicit purposes by individuals and groups wishing to obtain artifacts from archaeological sites on which they have no permission to detect. Information on the number and nature of incidents of illicit metal detecting, however, is difficult to collate owing both to the nature of the crime and to the way it is recorded (or not) by law enforcement authorities. In this article, we examine the strengths and limitations of the available official and unofficial sources on illicit metal detecting in England and Wales and explore the potential they have to tell us about current trends in this form of heritage crime. The first unofficial source is a list of incidents reported to Historic England, which contains basic information on 276 incidents recorded between 2010 and 2017. The second source is the result of a survey of the PAS’s finds liaison officers regarding the extent to which they assisted law enforcement authorities for the years from 2015 to 2017. Both sources were then contrasted with a freedom of information request that was sent to all 49 police forces in the United Kingdom. Although there are some synergies between the unofficial and official sources, the lack of detail in any one dataset makes them of limited use in demonstrating trends in the macro- and micro-scales of time and place. Accordingly, many of the issues highlighted in this article could be resolved by devising a better system for police record keeping of metal detecting offences.
The Passions and Religious Belief
Authors: Cottingham John 
Published: August 2019

AbstractMuch contemporary philosophy of religion suffers from an overly abstract and intellectualized methodology. A more ‘humane’ approach would acknowledge the vital contribution of the emotions and passions to a proper cognitive grasp of the nature of the cosmos and our place within it. The point is illustrated by reference to a number of writers, including Descartes, whose path to knowledge of God, often thought to depend on dispassionate argument alone, in fact relies on a synergy between intellect and emotions.
Passion for the Art of Morally Responsible Technology Development
Authors: Roeser Sabine , Steinert Steffen 
Published: August 2019

AbstractIn this article, we discuss the importance of emotions for ethical reflection on technological developments, as well as the role that art can play in this. We review literature that argues that emotions can and should play an important role in the assessment and acceptance of technological risk and in designing morally responsible technologies. We then investigate how technologically engagedartcan contribute to critical, emotional-moral reflection on technological risks. The role of art that engages with technology is unexplored territory and gives rise to many fascinating philosophical questions that have not yet been sufficiently addressed in the literature.