bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accurate Prediction Equation to Assess Body Fat in Male and Female Adolescent Football Players
Authors: Lozano-Berges Gabriel , Matute-Llorente Ángel , Gómez-Bruton Alejandro , González-Agüero Alejandro , Vicente-Rodríguez Germán , Casajús José A. 
Published: August 2018

The aims of this study were (a) to determine which of the most used anthropometric equations was the most accurate to estimate percentage of body fat (%BF), (b) to develop a new specific anthropometric equation, and (c) to validate this football-specific equation. A total of 126 (13.3 ± 0.6 years) football players (86 males and 40 females) participated in the present study. Participants were divided into two groups: 98 players were included in the assessment of existing equations and in the development of the new prediction equation, and 28 players were used to validate it. %BF was measured with dual-energy X-ray absorptiometry (DXA) and also estimated with six different %BF anthropometric equations: Johnston, Slaughter, Carter, Faulkner, Deurenberg, and Santi-Maria. Paired t tests were used to analyze differences between methods. A football-specific equation was developed by a stepwise linear regression. The existing anthropometric equations showed significant bias for %BF when compared with DXA (p < .001; constant error ranged from −4.57% to 9.24%; standard error of estimate ranged from 2.46 to 4.20). On the other hand, the developed football-specific equation was %BF = 11.115 + 0.775 (triceps skinfold) + 0.193 (iliac crest skinfold) − 1.606 (sex). The developed equation demonstrated neither %BF differences (p = .121; constant error = 0.57%; standard error of estimate = 0.36) when compared with DXA, presenting a high cross-validation prediction power (R2 = .85). Published anthropometric equations were not accurate to estimate %BF in adolescent football players. Due to the fact that the developed football-specific equation showed neither differences nor heteroscedasticity when compared with DXA, this equation is recommended to assess %BF in adolescent football players.
Factors influencing macular atrophy growth rates in neovascular age-related macular degeneration treated with ranibizumab or aflibercept according to an observe-and-plan regimen
Authors: Mantel Irmela , Zola Marta , De Massougnes Sophie , Dirani Ali , Bergin Ciara 
Published: August 2018

Background/aimsTo investigate the factors associated with macular atrophy (MA) growth rates in neovascular age-related macular degeneration treated with either ranibizumab or aflibercept.MethodsWe obtained data from two identical prospective studies using ranibizumab or aflibercept under observe-and-plan variable dosing regimens. We analysed eyes that presented MA within 2 years. After applying square root transformations to MA sizes, we calculated MA growth rate from baseline to the year 2 endpoint and used univariate and multivariate analyses to detect ocular and treatment factors associated with the MA growth rate.ResultsIncluded were 109 eyes from 101 patients (mean age 80.6 years). The mean square-root-transformed MA growth rate was 0.54±0.34 mm/year. The univariate analyses revealed that MA growth rates were significantly associated with lower baseline visual acuities (p=0.001) and thicker subretinal tissue complexes (p=0.006) and near-significantly associated with the presence of pigment epithelium detachment (p=0.057) and choroidal neovascularisation subtypes (p=0.069). Our multivariate analysis confirmed the significance of lower baseline visual acuities (p=0.008) and pigment epithelium detachments higher than 200 µm (p=0.035). Furthermore, MA growth rates in neovascular eyes significantly correlated with MA growth rates in non-neovascular fellow eyes (n=61; p=0.003).ConclusionMA growth rates were associated with ocular factors in the study eyes and the fellow eyes but not with the drug or the number of injections within this variable dosing regimen.
Discharge of patients with an acute upper gastrointestinal bleed from the emergency department using an extended Glasgow-Blatchford Score
Authors: Banister Thomas , Spiking Josesph , Ayaru Lakshmana 
Published: August 2018

ObjectiveTo use an extended Glasgow-Blatchford Score (GBS) cut-off of ≤1 to aid discharge of patients presenting with acute upper gastrointestinal bleeding (AUGIB) from emergency departments.BackgroundThe GBS accurately predicts the need for intervention and death in AUGIB, and a cut-off of 0 is recommended to identify patients for discharge without endoscopy. However, this cut-off is limited by identifying a low percentage of low-risk patients. Extension of the cut-off to ≤1 or ≤2 has been proposed to increase this proportion, but there is controversy as to the optimal cut-off and little data on performance in routine clinical practice.MethodsDual-centre study in which patients with AUGIB and GBS ≤1 were discharged from the emergency department without endoscopy unless there was another reason for admission. Retrospective analysis of associated adverse outcome defined as a 30-day combined endpoint of blood transfusion, intervention or death.Results569 patients presented with AUGIB from 2015 to 2018. 146 (25.7%) had a GBS ≤1 (70, GBS=0; 76, GBS=1). Of these, 103 (70.5%) were managed as outpatients, and none had an adverse outcome. GBS ≤1 had a negative predictive value=100% and the GBS had an area under receiver operator characteristic​​ (AUROC)=0.89 (95% CI 0.86 to 0.91) in predicting adverse outcomes. In 2008–2009, prior to risk scoring (n=432), 6.5% of patients presenting with AUGIB were discharged safely from the emergency department in comparison with 18.1% (p<0.001) in this cohort. A GBS cut-off ≤2 was associated with an adverse outcome in 8% of cases.ConclusionGBS of ≤1 is the optimal cut-off for the discharge of patients with an AUGIB from the emergency department.
Early prediction of lenvatinib treatment efficacy by using18F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma that is refractory to radioiodine treatment: a protocol for a non-randomized single-arm multicenter observational study
Authors: Takeuchi Satoshi , Shiga Tohru , Hirata Kenji , Taguchi Jun , Magota Keiichi , Ariga Shin , Gouda Tomohiro , Ohhara Yoshihito , Homma Rio , Shimizu Yasushi , Kinoshita Ichiro , Tsuji Yasushi , Homma Akihiro , Iijima Hiroaki , Tamaki Nagara , Dosaka-Akita Hirotoshi 
Published: August 2018

IntroductionLenvatinib, an oral molecular targeted drug, is used to treat patients with unresectable or advanced thyroid carcinoma that is refractory to radioiodine treatment. Effective methods for evaluating molecular targeted drugs are a critical unmet need owing to their expensive costs and unique adverse events. The aim of this study is to determine whether18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT at 1 week after commencing lenvatinib can predict treatment outcomes.Design and methodsThis study is planned as a non-randomised single-arm multicentre study; patients with pathologically confirmed differentiated thyroid carcinoma (DTC) with lesions that are refractory to radioiodine treatment are eligible. The main exclusion criteria are medullary or anaplastic carcinoma, prior treatment with chemotherapy, poor general condition and thromboembolism-requiring treatment. Patients to be included in the study will be treated with lenvatinib and undergo FDG-PET/CT examination twice: before and 1 week after the initiation of treatment. Contrast-enhanced CT, the gold standard for evaluation, will be performed at least 4 weeks after the initiation of treatment. The primary objective is to evaluate the ability of the lesion maximum standard uptake value for FDG PET/CT performed 1 week after the initiation of treatment to predict outcomes compared with the response evaluation obtained via contrast-enhanced CT performed at least 4 weeks after the initiation of treatment.Ethics and disseminationThis study is conducted in accordance with the Declaration of Helsinki and has received ethical approval from the institutional review board of the Hokkaido University Hospital (approval number: 015-402). The results of this study will be disseminated through a presentation at a conference and the publication of the data in a peer-reviewed journal. The study will be implemented and reported in line with the SPIRIT statement.Trial registration numberUMIN000022592.
Impact of patient characteristics on the Canadian Patient Experiences Survey–Inpatient Care: survey analysis from an academic tertiary care centre
Authors: Rubens Fraser D , Rothwell Diana M , Al Zayadi Amal , Sundaresan Sudhir , Ramsay Tim , Forster Alan 
Published: August 2018

ObjectiveTo determine the role of patient demographics, care domains and self-perceived health status in the analysis and interpretation of results from the Canadian Patient Experience Survey–Inpatient Care.DesignCross-sectional survey.SettingSingle large Canadian two campus tertiary care academic centre.ParticipantsRandom sampling of hospital patients postdischarge.Intervention and main outcome measuresLogistic regression models were developed to analyse topbox scoring on four questions of global care (rate experience, recommend hospital, rate hospital, overall helped). Means of each composite domain were correlated to the four overall scores at the patient level to determine Spearman’s rank correlation coefficients which were plotted against the overall (hospital) domain score for the key driver analysis.ResultsTopbox scoring was decreased with worse degrees of perceived physical and mental health in all four global questions (p<0.05). Female gender and higher levels of education were associated with worse scoring on rate experience, recommend hospital and rate hospital (p<0.001). Whereas there was a significant difference between hospital departments in unadjusted measures, these differences were no longer evident after adjustment with patient covariates. Key driver analysis identified person-centred care, care transition and the domain related to emergency admission as areas of highest potential for improvement.ConclusionsGlobal measures of overall care are influenced by patient-perceived physical and mental health. Caution should be exercised in using patient-satisfaction surveys to compare performance between different healthcare provision entities, as apparent differences could be explained by variation in patient mix rather than variation in performance.
Non-HFE mutations in haemochromatosis in China: combination of heterozygous mutations involving HJV signal peptide variants
Authors: Lv Tingxia , Zhang Wei , Xu Anjian , Li Yanmeng , Zhou Donghu , Zhang Bei , Li Xiaojin , Zhao Xinyan , Wang Yu , Wang Xiaoming , Duan Weijia , Wang Qianyi , Xu Hexiang , Zheng JiShun , Zhao Rongrong , Zhu Longdong , Dong Yuwei , Lu Lungen , Chen Yongpeng , Long Jiang , Zheng Sujun , Wang Wei , You Hong , Jia Jidong , Ou Xiaojuan , Huang Jian 
Published: August 2018

IntroductionHereditary haemochromatosis (HH) caused by a homozygous p.C282Y mutation in haemochromatosis (HFE) gene has been well documented. However, less is known about the causative non-HFE mutation. We aimed to assess mutation patterns of haemochromatosis-related genes in Chinese patients with primary iron overload.MethodsPatients were preanalysed for mutations in the classic HH-related genes: HFE, HJV, HAMP, TFR2 and SLC40A1. Whole exome sequencing was conducted for cases with variants in HJV signal peptide region. Representative variants were analysed for biological function.ResultsNone of the cases analysed harboured the HFE p.C282Y; however, 21 of 22 primary iron-overload cases harboured at least one non-synonymous variant in the non-HFE genes. Specifically, p.E3D or p.Q6H variants in the HJV signal peptide region were identified in nine cases (40.9%). In two of three probands with the HJV p.E3D, exome sequencing identified accompanying variants in BMP/SMAD pathway genes, including TMPRSS6 p.T331M and BMP4 p.R269Q, and interestingly, SUGP2 p.R639Q was identified in all the three cases. Pedigree analysis showed a similar pattern of combination of heterozygous mutations in cases with HJV p.E3D or p.Q6H, with SUGP2 p.R639Q or HJV p.C321X being common mutation. In vitro siRNA interference of SUGP2 showed a novel role of downregulating the BMP/SMAD pathway. Site-directed mutagenesis of HJV p.Q6H/p.C321X in cell lines resulted in loss of membrane localisation of mutant HJV, and downregulation of p-SMAD1/5 and HAMP.ConclusionCompound heterozygous mutations of HJV or combined heterozygous mutations of BMP/SMAD pathway genes, marked by HJV variants in the signal peptide region, may represent a novel aetiological factor for HH.
Estimating the effect of a potential policy to restrict tobacco retail availability in New Zealand
Authors: Robertson Lindsay , Marsh Louise 
Published: August 2018

IntroductionReducing tobacco retailer density is suggested to be a key component of tobacco endgames. Where tobacco retail reduction policies exist, ‘grandfathering’ is typically used, where existing retailers are exempt from restrictions aimed at reducing outlet density. We examined the possible impact on tobacco outlet density in New Zealand of a policy preventing new retail outlets from selling tobacco, but allowing existing retail outlets to continue selling tobacco until they ceased trading or relocated.MethodsWe obtained data on numbers of tobacco outlets and the number of outlet closures recorded annually from 2006 to 2016. We calculated the mean and the lowest and highest 3-year rolling average closure rates for each type of tobacco outlet. We projected decreases in the number of tobacco outlets that would hypothetically be permitted to sell tobacco from 2020 onwards and estimated when the combined number of tobacco outlets would decline by 50% and 95%.ResultsBased on mean annual closure rates, the total number of tobacco outlets would decrease by 50% by 2032 and a 95% reduction could be achieved by 2072. By 2025, the number of tobacco outlets would decrease by 27%; by 2050, this reduction would reach 84%.ConclusionA tobacco retail reduction policy that prevented new retail outlets from selling tobacco and grandfathered existing retailers would be unlikely to achieve New Zealand’s target of a 95% reduction in tobacco outlet density within several decades of being enacted. Nonetheless, this policy could achieve a 50% reduction in tobacco retail availability in the first decade of implementation.
Mobile website characteristics of leading tobacco product brands: cigarettes, smokeless tobacco, e-cigarettes, hookah and cigars
Authors: O’Brien Erin Keely , Navarro Mario Antonio , Hoffman Leah 
Published: August 2018

SignificanceMost US adults use smartphones for internet access. Understanding what they see when they view smartphone-optimised (mobile) tobacco websites is important, as it can inform tobacco education and cessation strategies. This study describes mobile tobacco websites for leading brands of cigarettes, cigars, smokeless tobacco (smokeless), e-cigarettes and hookah.MethodsWe identified 130 leading tobacco brands based on sales, advertising spending and self-report data. Of these, 62 brands had mobile websites. We conducted an inductive content analysis (ie, where we derived the coding scheme from what we observed) of website characteristics by dual-coding: age requirements, warning display, brand engagement methods (eg, social features) and sales strategies (eg, coupons).ResultsAll cigarette and most smokeless websites required age-verified accounts for entry, while 76% of e-cigarette websites required accounts only for making purchases. All cigarette and smokeless websites showed warnings, but a minority of e-cigarette and cigar websites did, and no hookah websites did. Many websites required users to scroll up to view warnings. Most e-cigarette websites, most hookah websites, and half of cigar websites linked to multiple social media platforms; however, most cigarette and smokeless websites facilitated socialisation internally. All cigarette, most smokeless and no hookah websites offered coupons. Many cigarette and smokeless coupons were time-sensitive and location-based.ConclusionsWe highlight issues in how tobacco brand websites address youth access, display warnings, engage consumers and facilitate purchase. Results can help public health educators and practitioners better understand tobacco marketing as a context for designing tobacco interventions.
Reachability Is in DynFO
Authors: Datta Samir , Kulkarni Raghav , Mukherjee Anish , Schwentick Thomas , Zeume Thomas 
Published: August 2018

Patnaik and Immerman introduced the dynamic complexity class DynFO of database queries that can be maintained by first-order dynamic programs with the help of auxiliary relations under insertions and deletions of edges. This article confirms their conjecture that the reachability query is in DynFO.
As a byproduct, it is shown that the rank of a matrix with small values can be maintained in DynFO. It is further shown that the (size of the) maximum matching of a graph can be maintained in non-uniform DynFO, an extension of DynFO, with non-uniform initialisation of the auxiliary relations.
Block Cooperation
Authors: Tavana Mohammad Khavari , Ziabari Amir Kavyan , Kaeli David 
Published: August 2018

Block-level cooperation is an endurance management technique that operates on top of error correction mechanisms to extend memory lifetimes. Once an error recovery scheme fails to recover from faults in a data block, the entire physical page associated with that block is disabled and becomes unavailable to the physical address space. To reduce the page waste caused by early block failures, other blocks can be used to support the failed block, working cooperatively to keep it alive and extend the faulty page’s lifetime.
We combine the proposed technique with existing error recovery schemes, such as Error Correction Pointers (ECP) and Aegis, to increase memory lifetimes. Block cooperation is realized through metadata sharing in ECP, where one data block shares its unused metadata with another data block. When combined with Aegis, block cooperation is realized through reorganizing data layout, where blocks possessing few faults come to the aid of failed blocks, bringing them back from the dead.
Our evaluation using Monte Carlo simulation shows that block cooperation at a single level (or multiple levels) on top of ECP and Aegis, boosts memory lifetimes by 28% (37%) and 8% (14%) on average, respectively. Furthermore, using trace-driven benchmark evaluation shows that lifetime boost can reach to 68% (30%) exploiting metadata sharing (or data layout reorganization).
Mosaic
Authors: Ausavarungnirun Rachata , Landgraf Joshua , Miller Vance , Ghose Saugata , Gandhi Jayneel , Rossbach Christopher J. , Mutlu Onur 
Published: August 2018

Contemporary discrete GPUs support rich memory management features such as virtual memory and demand paging. These features simplify GPU programming by providing a virtual address space abstraction similar to CPUs and eliminating manual memory management, but they introduce high performance overheads during (1) address translation and (2) page faults. A GPU relies on high degrees of thread-level parallelism (TLP) to hide memory latency. Address translation can undermine TLP, as a single miss in the translation lookaside buffer (TLB) invokes an expensive serialized page table walk that often stalls multiple threads. Demand paging can also undermine TLP, as multiple threads often stall while they wait for an expensive data transfer over the system I/O (e.g., PCIe) bus when the GPU demands a page.
In modern GPUs, we face a trade-off on how the page size used for memory management affects address translation and demand paging. The address translation overhead is lower when we employ a larger page size (e.g., 2MB large pages, compared with conventional 4KB base pages), which increases TLB coverage and thus reduces TLB misses. Conversely, the demand paging overhead is lower when we employ a smaller page size, which decreases the system I/O bus transfer latency. Support for multiple page sizes can help relax the page size trade-off so that address translation and demand paging optimizations work together synergistically. However, existing page coalescing (i.e., merging base pages into a large page) and splintering (i.e., splitting a large page into base pages) policies require costly base page migrations that undermine the benefits multiple page sizes provide. In this paper, we observe that GPGPU applications present an opportunity to support multiple page sizes without costly data migration, as the applications perform most of their memory allocation en masse (i.e., they allocate a large number of base pages at once).We show that this en masse allocation allows us to create intelligent memory allocation policies which ensure that base pages that are contiguous in virtual memory are allocated to contiguous physical memory pages. As a result, coalescing and splintering operations no longer need to migrate base pages.
Cardiovascular and skeletal muscle health with lifelong exercise
Authors: Gries Kevin J. , Raue Ulrika , Perkins Ryan K. , Lavin Kaleen M. , Overstreet Brittany S. , D’Acquisto Leonardo J. , Graham Bruce , Finch W. Holmes , Kaminsky Leonard A. , Trappe Todd A. , Trappe Scott 
Published: August 2018

The purpose of this study was to examine the effects of aerobic lifelong exercise (LLE) on maximum oxygen consumption (V̇o2max) and skeletal muscle metabolic fitness in trained women ( n = 7, 72 ± 2 yr) and men ( n = 21, 74 ± 1 yr) and compare them to old, healthy nonexercisers (OH; women: n = 10, 75 ± 1 yr; men: n = 10, 75 ± 1 yr) and young exercisers (YE; women: n = 10, 25 ± 1 yr; men: n = 10, 25 ± 1 yr). LLE men were further subdivided based on intensity of lifelong exercise and competitive status into performance (LLE-P, n = 14) and fitness (LLE-F, n = 7). On average, LLE exercised 5 day/wk for 7 h/wk over the past 52 ± 1 yr. Each subject performed a maximal cycle test to assess V̇o2maxand had a vastus lateralis muscle biopsy to examine capillarization and metabolic enzymes [citrate synthase, β-hydroxyacyl-CoA dehydrogenase (β-HAD), and glycogen phosphorylase]. V̇o2maxhad a hierarchical pattern (YE > LLE > OH, P < 0.05) for women (44 ± 2 > 26 ± 2 > 18 ± 1 ml·kg−1·min−1) and men (53 ± 3 > 34 ± 1 > 22 ± 1 ml·kg−1·min−1) and was greater ( P < 0.05) in LLE-P (38 ± 1 ml·kg−1·min−1) than LLE-F (27 ± 2 ml·kg−1·min−1). LLE men regardless of intensity and women had similar capillarization and aerobic enzyme activity (citrate synthase and β-HAD) as YE, which were 20%–90% greater ( P < 0.05) than OH. In summary, these data show a substantial V̇o2maxbenefit with LLE that tracked similarly between the sexes, with further enhancement in performance-trained men. For skeletal muscle, 50+ years of aerobic exercise fully preserved capillarization and aerobic enzymes, regardless of intensity. These data suggest that skeletal muscle metabolic fitness may be easier to maintain with lifelong aerobic exercise than more central aspects of the cardiovascular system.NEW & NOTEWORTHY Lifelong exercise (LLE) is a relatively new and evolving area of study with information especially limited in women and individuals with varying exercise intensity habits. These data show a substantial maximal oxygen consumption benefit with LLE that tracked similarly between the sexes. Our findings contribute to the very limited skeletal muscle biopsy data from LLE women (>70 yr), and similar to men, revealed a preserved metabolic phenotype comparable to young exercisers.