bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-vitro Antioxidant and Anti-inflammatory Activities of Quisqualis indica Linn. Leaves Extract
Authors: Pal Pallavi , Singh Ajeet 
Published: March 2019

Aim: In this study antioxidant and anti-inflammatory effect of ethanolic extract of Quisqualis indica leaves was evaluated.
Study Design: In-vitro analysis of Quisqualis indica leaf extract.
Place and Duration of Study: Molecular Biology laboratory, Department of Biotechnology, G.B Pant Engineering College, Pauri, between July 2015 and July 2016.
Methods: Non-enzymatic and enzymatic assays such as DPPH (1, 1diphenyl-2-picryl hydrazyl), FRAP assay, superoxide dismutase SOD (EC 1.15.1.1), catalase (EC 1.11.1.6), for radical scavenging activity of ethanolic extracts of Quisqualis indica Linn. plant leaves had done. For estimation of anti-inflammatory action, two methods were employed: protein denaturation method and membrane stabilization method.
Results: Ethanolic extract of leaves on higher concentration had better antioxidant potential when compared with reference standard ascorbic acid. They exhibited strong antioxidant radical scavenging activity values for ethanolic extract of leaves. Results of anti-inflammatory method suggested better potential values for ethanolic extract and compared with standard drug diclofenac sodium respectively. A significant relationship between antioxidant, anti-inflammatory capacity and total phenolic content was examined, indicating that phenolic compounds are the major contributors for the antioxidant and anti-inflammatory properties of this plant.
Conclusion: Ethanolic extract of Q. indica exhibited strong anti-inflammatory and antioxidant activity and this can be used for designing novel drug inhibitors with better efficacy.
Histological Assessment on Cadmium Induced Liver Damage Following Oral Administration of Moringa oleifera Oil and Anarcardium occidentale Nuts Oil in Wistar Rats
Authors: Omotoso O. D. , Adelakun S. A. , Oyewo O. O. , Adediran B. T. 
Published: March 2019

Background: Cadmium is a human carcinogen element and one of the most toxic pollutants in the environment. Present study aims at histomorphological study of some of the effects of Moringa oleifera oil and cashew (Anarcardium occidentale) nuts oil on Cadmium-induced liver damage in wistar rats.
Methods: Thirty-five Wistar rats (80-180 g) were randomly selected and divided into seven groups of five rats each after acclimatization for two weeks. Group A which served as control received phosphate buffer, Group B received Cadmium only (3.5 mg/kg body weight). Group C received Vitamin C and Vitamin E; Group D received Vitamin C, Vitamin E and Cadmium. Group E received Cadmium and Moringa oleifera oil, Group F received Cadmium and Cashew nut oil and Group G received Cadmium (3.5 mg/kg body weight) and Moringa oleifera oil and Cashew (Anarcardium occidentale) nut oil.
Results: Histological examination revealed normal histo-architecture of the liver, the central vein and the hepatocytes were seen clearly and there was orderly arrangement of the hepatocytes in Group A (control group). In group B, there was enlarged portal vein and there was distorted arrangement of the hepatocytes. In group C, the hepatocytes and the central vein were seen. In group D, the central vein and hepatocytes were seen though not orderly arranged. In groups E, F and G, there was restoration of the hepatocytes and the central vein was seen.
Conclusion: This therefore suggests that Moringa oleifera oil and Cashew (Anarcardium occidentale) nut oil have ameliorative effects which led to the restoration of the damaged and distorted hepatocytes.
CSF placental growth factor – a novel candidate biomarker of frontotemporal dementia
Authors: Hansson Oskar , Santillo Alexander F. , Meeter Lieke H. , Nilsson Karin , Landqvist Waldö Maria , Nilsson Christer , Blennow Kaj , van Swieten John C. , Janelidze Shorena 
Published: March 2019

AbstractObjectiveDiagnosis of frontotemporal dementia (FTD) is complicated by the overlap of clinical symptoms with other dementia disorders. Development of robust fluid biomarkers is critical to improve the diagnostic work‐up of FTD.MethodsCSF concentrations of placental growth factor (PlGF) were measured in the discovery cohort including patients with FTD (n = 27), Alzheimer disease (AD) dementia (n = 75), DLB or PDD (n = 47), subcortical vascular dementia (VaD, n = 33), mild cognitive impairment that later converted to AD (MCI‐AD, n = 34), stable MCI (sMCI, n = 62), and 50 cognitively healthy controls from the Swedish BioFINDER study. For validation, CSF PlGF was measured in additional independent cohort of FTD patients (n = 22) and controls (n = 18) from the Netherlands.ResultsIn the discovery cohort, MCI, MCI‐AD, AD dementia, DLB‐PDD, VaD, and FTD patients all showed increased CSF levels of PlGF compared with controls (sMCI P = 0.019; MCI‐AD P = 0.005; AD dementia, DLB‐PDD, VaD, and FTD all P < 0.001). PlGF levels were 1.8–2.1‐fold higher in FTD than in AD, DLB‐PDD and VaD (all P < 0.001). PlGF distinguished with high accuracy FTD from controls and sMCI performing better than tau/Aβ42 (AUC 0.954–0.996 versus 0.564–0.754, P < 0.001). A combination of PlGF, tau, and Aβ42 (tau/Aβ42/PlGF) was more accurate than tau/Aβ42 when differentiating FTD from a group of other dementias (AUC 0.972 vs. 0.932, P < 0.01). Increased CSF levels of PlGF in FTD compared with controls were corroborated in the validation cohort.InterpretationCSF PlGF is increased in FTD compared with other dementia disorders, MCI, and healthy controls and might be useful as a diagnostic biomarker of FTD.
Rheumatic Care in Under‐Resourced Areas Using the Extension for Community Healthcare Outcomes Model
Authors: Bankhurst Arthur , Romero‐Olivas Cynthia , Hernandez Larson Jessica , Bradford Andrea , Fields Roderick , Kalishman Summers , Marquez Marisa , Gonzales‐Van Horn Sarah , Jones Jessica , Burke Tom , Snead Jennifer , Arora Sanjeev 
Published: March 2019

ObjectiveTo demonstrate the effectiveness of the Extension for Community Healthcare Outcomes (Project ECHO) in educating primary care clinicians (PCCs) to provide best practice rheumatic care to patients in under‐resourced communities in New Mexico.MethodsAttendee data for weekly teleECHO sessions, lectures, grand rounds, and mini‐residency trainings were evaluated from June 2006 to June 2014. Participant feedback was evaluated from January 2009 to December 2014, when the program was approved for continuing medical education (CME) credits. Retrospective review of diagnoses associated with case presentations was conducted from June 2006 to June 2014 to evaluate the types of cases presented. A focus group was conducted with a convenience sample of 8 New Mexico PCCs who participated in ECHO Rheumatology (ECHO Rheum) for 1 year or longer.ResultsOver the course of 9 years, ECHO Rheum educated 2,230 clinicians, consisting primarily of physicians (53%) and nurse practitioners (22%). A total of 1,958 CME credits were awarded to those who participated. There were 1,173 cases presented; 85% of the cases reflected the 3 most common diagnoses: rheumatoid arthritis (n = 715), fibromyalgia (n = 241), and systemic lupus erythematosus (n = 54). In addition, ECHO Rheum conducted 15 two‐day mini‐residencies involving 30 PCCs; 21 of these clinicians subsequently completed the American College of Rheumatology online certification.ConclusionResults from this study demonstrate that participation in ECHO Rheum provides clinicians in under‐resourced areas access to best‐practice knowledge and training in rheumatology.
Therapeutic Alliance Between Physical Therapists and Patients With Knee Osteoarthritis Consulting Via Telephone: A Longitudinal Study
Authors: Lawford Belinda J. , Bennell Kim L. , Campbell Penny K. , Kasza Jessica , Hinman Rana S. 
Published: March 2019

ObjectiveTo explore therapeutic alliance between physical therapists and patients with knee osteoarthritis during telephone consultations. Specifically, to describe and compare physical therapist and patient ratings, to determine whether alliance changes over time, and to evaluate whether individual characteristics are associated with alliance.MethodsWe performed a secondary analysis of 84 patients in the intervention arm of a randomized controlled trial who completed 5–10 consultations with 1 of 8 physical therapists via telephone over 26 weeks, involving education, advice, and prescription of a strengthening and physical activity program. Therapeutic alliance was measured after the second (week 4) and final consultations (week 26), using the Working Alliance Inventory–Short Form.ResultsPatient and physical therapist ratings of the alliance were high. At week 4, patients rated the overall alliance, and all 3 subscales, higher than therapists. At 26 weeks, patients rated the Task subscale higher than therapists. Patient ratings for the Goal subscale decreased over time, while physical therapist ratings for total alliance and the Bond subscale increased. For patients, the variables of living with others, consulting with a therapist with no previous experience delivering care remotely, having more telephone consultations, and having a higher self‐efficacy were associated with greater alliance ratings. Therapists were more likely to perceive a stronger alliance if they had less clinical experience and when treating patients who were younger and had higher self‐efficacy.ConclusionPhysical therapist perceptions of the therapeutic alliance tended to be lower than those of patients early in treatment, but differences were small and of unclear clinical significance. Some subgroups of patients rated the alliance more strongly than others.
Supervised Group Exercise in Axial Spondyloarthritis: Patients' Satisfaction and Perspective on Evidence‐Based Enhancements
Authors: Hilberdink Bas , van der Giesen Florus , Vliet Vlieland Thea , van Gaalen Floris , van Weely Salima 
Published: March 2019

ObjectiveSupervised group exercise (SGE) has been proven effective in patients with axial spondyloarthritis (SpA), but its contents and dosage do not always comply with current scientific insight. This aim of this study was to describe axial SpA patients' satisfaction with current SGE and perspective on potential evidence‐based SGE enhancements.MethodsPatients with axial SpA who participated in SGE in 4 regions in The Netherlands (n = 118) completed a cross‐sectional survey on their satisfaction with features of their current SGE (8 questions scored on a 3‐point Likert scale; 1 overall grade, scored according to an 11‐point scale) and their perspective on the introduction of appropriately dosed cardiorespiratory and strengthening exercise, monitoring of exercise intensity, periodic reassessments, patient education, and supervision by physical therapists with specific expertise (4 dichotomous questions and one 5‐point Likert scale).ResultsMost patients were satisfied with the current total intensity (84 of 112 patients [75%]), duration (93 of 111 patients [84%]), and load (89 of 117 patients [76%]) of the program and the proportion of mobility (102 of 114 patients [90%]), strengthening (90 of 115 patients [78%]), and cardiorespiratory exercise (82 of 114 patients [72%]). The median overall grade of the program was a 7 (interquartile range 7–8). Most patients agreed with the implementation of more frequent (home) exercise (73 of 117 patients [62%]), heart‐rate monitoring (97 of 117 patients [83%]), and annual reassessments (97 of 118 patients [82%]), whereas 50% agreed with the introduction of patient education (37 of 74 patients). The majority found supervision by therapists specializing in axial SpA to be of high importance (105 of 118 patients [89%]).ConclusionThe majority of SGE participants with axial SpA were satisfied with current SGE but also agreed with enhancements in line with scientific evidence. Current satisfaction levels indicate that a planned implementation strategy, including education and addressing potential barriers and facilitators for the uptake of enhancements, is warranted.
Brønsted Acid Mediated Synthesis and Properties of Dibenzoacridine Derivatives
Authors: Flader Anika , Ohlendorf Lars , Ehlers Peter , Ammon Erich , Villinger Alexander , Langer Peter 
Published: March 2019

AbstractAn efficient and convenient method for the synthesis of dibenzo[c,h]acridine derivatives via electrophilic cycloisomerisation mediated by methanesulfonic acid has been developed. This method provides the desired acridines in moderate to very good yields introducing various substituents in positions 2 and 6 as well as on the dibenzo[c,h]acridine scaffold. Photophysical and electrochemical properties have been investigated for selected products by UV/Vis and CV measurements which have been verified by DFT calculations.magnified image
Rhodium‐Catalyzed C−H Functionalization of N‐(2‐Pyrimidyl)indole with Internal Alkynes: Formation of Unexpected Products by Regulating the Amount of Silver Acetate
Authors: Li Tongyu , Wang Zhuo , Chen Chen , Zhu Bolin 
Published: March 2019

AbstractHerein we disclose an uncommon Rhodium(III)‐catalyzed C2‐selective functionalization of N‐(2‐Pyrimidyl)indole with internal alkynes. Excess amounts of silver acetate (5.0 equiv.) were found to be crucial for the efficient C2 naphthylation and C2 enol esterification of indoles. In sharp contrast, 2.0 equivalents of silver acetate resulted in the C−H alkenylation only. Control experiments were also carried out to briefly study the mechanism of this transformation.magnified image
Efficient Pincer‐Ruthenium Catalysts for Kharasch Addition of Carbon Tetrachloride to Styrene
Authors: Das Kanu , Dutta Moumita , Das Babulal , Srivastava Hemant Kumar , Kumar Akshai 
Published: March 2019

AbstractA series of NNN pincer‐ruthenium complexes (R2NNN)RuCl2(PPh3) (R=Cyclohexyl (Cy), t‐butyl (tBu), i‐propyl (iPr) and phenyl (Ph)) have been synthesized and characterized. These pincer‐ruthenium complexes have been used to catalyse the Kharasch addition or atom transfer radical addition (ATRA) of carbon tetrachloride to styrene. Among the pincer‐ruthenium catalysts screened for the Kharasch addition, the catalytic activity followed the order (Cy2NNN)RuCl2(PPh3)>(iPr2NNN)RuCl2(PPh3)≫(Ph2NNN)RuCl2(PPh3). The oxidation of Ru(II) is easier with (Cy2NNN)RuCl2(PPh3) and (iPr2NNN)RuCl2(PPh3) in comparison with
RuCl2(PPh3) as indicated by cyclic voltammetry studies. The catalyst precursor (R2NNN)RuCl2(PPh3) itself is the resting state of the reaction. The rate determining step involves the generation of the five‐coordinate 16‐electron ruthenium(II) species (R2NNN)RuCl2. Owing to weaker binding of triphenyl phosphine to ruthenium, the generation of catalytically active 16‐electron species (Cy2NNN)RuCl2 and (iPr2NNN)RuCl2 are more favourable. The complex (Cy2NNN)RuCl2(PPh3) demonstrates very high productivity (5670 turnovers after 48 h at 140 °C) in the absence of any co‐catalyst radical initiator. To the best of our knowledge, our turnovers (ca. 5670) are much higher than that reported hitherto. Quantum mechanical calculations demonstrate that the path involving the activation of carbon tetrachloride by (Cy2NNN)RuCl2 is more favoured than the path where carbon tetrachloride is activated by (Cy2NNN)RuCl2(η2‐styrene). Density functional theory (DFT) and kinetic studies are in accord with the widely accepted mechanism involving the single electron transfer (SET) from ruthenium(II) to chloride radical with concomitant generation of a benzyl radical which is trapped by the resulting ruthenium(III) species.magnified image
Gold‐Catalyzed Stereoselective Domino Cyclization/Alkynylation of N‐Propargylcarboxamides with Benziodoxole Reagents for the Synthesis of Alkynyloxazolines
Authors: Zhao Ximei , Tian Bing , Yang Yangyang , Si Xiaojia , Mulks Florian F. , Rudolph Matthias , Rominger Frank , Hashmi A. Stephen K. 
Published: March 2019

AbstractA concise and highly stereoselective synthesis of alkynyloxazolines via a gold‐catalyzed domino cyclization‐alkynylation cascade of N‐propargylcarboxamides with benziodoxole reagents is reported. This new protocol, which represents an attractive alternative to two step sequences based on Sonagashira couplings, offers a broad substrate scope, excellent functional group tolerance, and perfect stereoselectivity. A comparison of the computed energies of the isomers of the product suggests kinetic control as the cause of the observed selectivity.magnified image
The effect of gender diversity on the board of Spanish agricultural cooperatives on returns and debt: An empirical analysis
Authors: Hernández‐Nicolás Carmen María , Martín‐Ugedo Juan Francisco , Mínguez‐Vera Antonio 
Published: March 2019

AbstractThis paper focuses on gender diversity on the boards of Spanish agricultural cooperatives. Specifically, it examines the effect that gender diversity on the board exerts on returns, debt level, and economic risk. Cooperatives differ significantly from investor‐owned firms because cooperative members are producers, agents, and customers of the cooperatives. In Spain, there is an ongoing debate about the importance of women in business management. Spain is also a pioneer in terms of enacting specific legislation for the social economy. The sample examined includes 672 agricultural cooperatives. The results show that firms with greater female representation on their boards have higher returns and operational risk and lower levels of debt. [EconLit Classifications: J16, J54, Q13].
A solitary colonic ulcer found 15 years after heart transplantation: A case report
Authors: Tsai Tzung‐Jiun , Hsu Ping‐I , Cheng Jin‐Shiung , Chen Wen‐Chi 
Published: March 2019

AbstractThe clinical manifestations of cytomegalovirus (CMV) infection are divergent. Here, we report a patient with a solitary ulcerative lesion in the ascending colon at 15 years after heart transplantation detected by routine stool immunochemical occult blood test. Biopsy demonstrated it to be CMV colitis. The colon ulcer healed after valganciclovir treatment for 3 months.
Das Aufkommen der organischen Einkristallelektronik
Authors: Jiang Hui , Hu Wenping 
Published: March 2019

AbstractOrganische halbleitende Einkristalle eignen sich sowohl für die Grundlagenforschung als auch für die anwendungsorientierte Forschung aufgrund der Vorteile von freien Korngrenzen, wenigen Fehlstellen, Ladungsträgerfallen und Verunreinigungen sowie der Tieftemperaturverarbeitbarkeit, der hohen Flexibilität und der niedrigen Herstellungskosten. Ladungsträgerbeweglichkeiten von mehr als 10 cm2 V−1 s−1 in einigen organischen Einkristallen sind vielversprechend für die Anwendung in elektronischen Bauteilen. Die bisherigen Ergebnisse, einschließlich der Molekülstrukturen und Techniken zur Herstellung organischer Einkristalle, werden hier vorgestellt. Organisch‐einkristalline elektronische Bauteile, einschließlich Feldeffekttransistoren, Phototransistoren, p‐n‐Heteroübergänge und Schaltungen, werden ebenfalls diskutiert. Des Weiteren werden zweidimensionale organische Einkristalle, Cokristalle sowie große Einkristalle samt einigen möglichen Anwendungen vorgestellt. Damit wird ein aktueller Überblick über die organische Einkristallelektronik mit ihren Herausforderungen und Perspektiven geboten.
Effects of the molecular structure on the vibration reduction and properties of hyperbranched waterborne polyurethane–acrylate for damping coatings
Authors: Zhang Qiuxue , Deng Yunjiao , Fu Zhongyu , Zhang Huixuan 
Published: March 2019

ABSTRACTA series of hyperbranched waterborne polyurethane–acrylate (HWPUA) hybrid emulsions were prepared with isocyanate‐terminated PU prepolymers, hyperbranched polyol (HP), and acrylate monomers. The HP as crosslinker was synthesized with isophorone diisocyanate, dimethylol propionic acid, and diethanol amine. The influence of the HP content on the chemical structure, particle size, morphology, damping properties, and thermal stability of the HWPUA hybrid emulsions and films were investigated by Fourier transform infrared spectroscopy, dynamic light scattering, transmission electron microscopy, dynamic mechanical analysis (DMA), and thermogravimetric analysis, respectively. The results show that the addition of HP obviously improved the damping and thermal properties of the HWPUA films. However, the addition of excessive HP had a detrimental impact on the performance of films. The DMA curves indicated that when the HP content was 1%, tan δ was 0.3 or greater and spanned the broadest temperature range, with a maximum value of 0.65. The HWPUA hybrid emulsions could be used as damping coatings. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2019,136, 47733.
Newly Identified HNP‐F from Human Neutrophil Peptide‐1 Promotes Hemostasis
Authors: Kim Ki Chan , Lee Woogi , Lee Jaeyun , Cha Hyung Joon , Hwang Byeong Hee 
Published: March 2019

Active hemostatic agents can play a crucial role in saving patients’ lives during surgery. Active hemostats have several advantages including utilization of natural blood coagulation and biocompatibility. Among them, although human neutrophil peptide‐1 (HNP‐1) has been previously reported with the hemostatic mechanism, which part of HNP‐1 facilitates the hemostatic activity is not known. Here, a partial peptide (HNP‐F) promoting hemostasis, originating from HNP‐1, has been newly identified by the blood coagulation ability test. HNP‐F shows the best hemostatic effect between the anterior half and posterior half of peptides. Moreover, microscopic images show platelet aggregation and an increase in the concentration of platelet factor 4, and the scanning electron microscope image of platelets support platelet activation by HNP‐F. Thromboelastography indicates decreased clotting time and increased physical properties of blood clotting. Mouse liver experiments demonstrate improved hemostatic effect by treatment of peptide solution. Cell viability and hemolysis assays confirm the HNP‐F's biosafety. It is hypothesized that the surface charge and structure of HNP‐F could be favorable to interact with fibrinogen or thrombospondin‐1. Collectively, because HNP‐F as an active peptide hemostat has many advantages, it could be expected to become a potent hemostatic biomaterial, additive or pharmaceutical candidate for various hemostatic applications.
Identification of the Hypertension Drug Guanfacine as an Antivirulence Agent in Pseudomonas aeruginosa
Authors: Okada Bethany K. , Li Anran , Seyedsayamdost Mohammad R. 
Published: March 2019

AbstractAn alternative solution to the cyclical development of new antibiotics is the concept of disarming pathogens without affecting their growth, thereby eliminating the selective pressures that lead to resistant phenotypes. Here, we have employed our previously developed HiTES methodology to identify one such compound against the ESKAPE pathogen Pseudomonas aeruginosa. Rather than induce silent biosynthetic gene clusters, we used HiTES to suppress actively expressed virulence genes. By screening a library of 770 FDA‐approved drugs, we identified guanfacine, a clinical hypertension drug, as an antivirulence agent in P. aeruginosa. Follow‐up studies showed that guanfacine reduces biofilm formation and pyocycanin production without altering growth. Moreover, we identified a homologue of QseC, a sensor His kinase used by multiple pathogens to turn on virulence, as a target of guanfacine. Our studies suggest that guanfacine might be an attractive antivirulence lead in P. aeruginosa and provide a template for uncovering such molecules by screening for downregulators of actively expressed biosynthetic genes.
Acquired neonatal bronchial stenosis after selective intubation: Successful managed with balloon dilatation
Authors: Goussard Pierre , Morrison Julie , Bekker Adrie , Fourie Barend 
Published: March 2019

Key Clinical MessagePremature babies are prone to airway‐related complications. Selective intubation for the management of pulmonary interstitial emphysema may cause acquired bronchial stenosis. Balloon dilatation under fluoroscopy is a safe minimal invasive and successful intervention for acquired bronchial stenosis. Follow‐up bronchoscopy is needed due to risk of restenosis.