bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histone Modification Patterns Using RPPA‐Based Profiling Predict Outcome in Acute Myeloid Leukemia Patients
Authors: van Dijk Anneke D. , Hu Chenyue W. , de Bont Eveline S.J.M. , Qiu YiHua , Hoff Fieke W. , Yoo Suk Young , Coombes Kevin R. , Qutub Amina A. , Kornblau Steven M. 
Published: March 2018

AbstractPosttranslational histone tail modifications are known to play a role in leukemogenesis and are therapeutic targets. A global analysis of the level and patterns of expression of multiple histone‐modifying proteins (HMP) in acute myeloid leukemia (AML) and the effect of different patterns of expression on outcome and prognosis has not been investigated in AML patients. Here we analyzed 20 HMP by reverse phase protein array (RPPA) in a cohort of 205 newly diagnosed AML patients. Protein levels were correlated with patient and disease characteristics, including survival and mutational state. We identified different protein clusters characterized by higher (more on) or lower (more off) expression of HMP, relative to normal CD34+ cells. On state of HMP was associated with poorer outcome compared to normal‐like and a more off state. FLT3 mutated AML patients were significantly overrepresented in the more on state. DNA methylation related mutations showed no correlation with the different HMP states. In this study, we demonstrate for the first time that HMP form recurrent patterns of expression and that these significantly correlate with survival in newly diagnosed AML patients.
3D Array of Bi2S3 Nanorods Supported on Ni Foam as a Highly Efficient Integrated Oxygen Electrode for the Lithium‐Oxygen Battery
Authors: Shu Chaozhu , Liu Yunhan , Long Jianping , Chen Xianfei , Su Yang 
Published: March 2018

AbstractBismuth sulfide nanorod array is directly grown on nickel foam (R‐Bi2S3/NF) to serve as a completely carbon and binder‐free 3D porous oxygen electrode material for lithium‐oxygen (Li‐O2) batteries. The synergistic effect of the fast kinetics of electron transport and gas and electrolyte diffusion provided by the continuous free‐standing network structure and the excellent electrocatalytic activity of the bismuth sulfide nanorod array enables outstanding performance of the oxygen electrode. Li‐O2 battery with the free‐standing R‐Bi2S3/NF oxygen electrode exhibits high energy efficiency (78.7%), good rate capability (4464 mA h g−1 at 1500 mA g−1), as well as excellent cyclability (146 cycles) while maintaining a moderate specific capacity of 1000 mA h g−1. The effect of cathodes with different reactant (O2) and intermediate (LiO2) adsorbability on the product (Li2O2) growth model is studied by first‐principle calculations. The strong O2 adsorption and weak LiO2 adsorption on Bi2S3 drives the growth of large‐size Li2O2 particles via solution growth model. Remarkably, the large‐area pouch‐type Li‐O2 battery delivers an energy density of 330 Wh kg−1. The present results open up a promising avenue toward developing novel electrode architecture for high‐performance Li‐O2 batteries through controlling morphology and functionality of porous electrodes.
Synthesis and Characterization of New PGN Based Reactive Oligomeric Plasticizers for Glycidyl Azide Polymer
Authors: Bodaghi Asghar , Shahidzadeh Mansour 
Published: March 2018

AbstractNew heterobifunctional oligomeric energetic plasticizer with alkyne at one end and a hydroxyl group at the other end, was synthesized via ring opening polymerization of glycidyl nitrate monomer, propargyl alcohol as initiator and BF3 as a catalyst. The terminal hydroxyl group of plasticizer capped with methoxy and acetyl groups to generate two other types of reactive plasticizer. The chemical structure of plasticizers has characterized by FT‐IR and 1H NMR spectroscopy as well as DSC, and TGA methods. Also, plasticizers reactivity toward alkyne‐azide reaction, have evaluated through LUMO energy level calculation of reactive plasticizer that containing one and two repeating units in their structure. Moreover, the results show that grafting up to 10 % of the total amount of azide groups of GAP, reduces the viscosity and the glass transition temperature of GAP‐g‐PGN copolymer in comparison to glycidyl azide polymer.
Processed kaolin affects the probing and settling behavior of Diaphorina citri (Hemiptera: Lividae)
Authors: Miranda Marcelo P , Zanardi Odimar Z , Tomaseto Arthur F , Volpe Haroldo XL , Garcia Rafael B , Prado Ernesto 
Published: March 2018

AbstractBACKGROUNDAlternative methods that have the potential to reduce the entry of Diaphorina citri Kuwayama (Hemiptera: Liviidae), the major citrus pest worldwide, into commercial groves could be a viable approach for huanglongbing management. Kaolin is an aluminum silicate that when sprayed on plants forms a white particle film that interferes with host recognition by the insects. Diaphorina citri orients towards the host plants by visual and olfactory cues. The purpose of the study was to determine the effect of processed kaolin on D. citri settling (no‐choice) and probing behavior [electrical penetration graph (EPG) technique] under laboratory conditions, and to study its host plant finding ability and dispersal under field conditions in the absence and presence of young shoots.RESULTSUnder laboratory conditions, kaolin caused an overall reduction of 40% in the number of psyllids settled on treated seedlings; furthermore, the proportion of individuals that were able to reach the phloem was 50% lower on kaolin‐treated plants than on untreated plants. In the field, the plant finding ability of D. citri was disrupted on kaolin‐treated trees (overall reduction of 96%), regardless of the vegetative condition, and psyllid dispersal was slower in kaolin‐treated plots than in the untreated control.CONCLUSIONThis study clearly demonstrates that processed kaolin interferes negatively with different aspects of the host plant finding ability of D. citri. These findings suggest that processed kaolin has a high potential to reduce huanglongbing primary infection. © 2018 Society of Chemical Industry
Actual versus implied physics students: How students from traditional physics classrooms related to an innovative approach to quantum physics
Authors: Bøe Maria Vetleseter , Henriksen Ellen Karoline , Angell Carl 
Published: March 2018

AbstractCalls for renewal of physics education include more varied learning activities and increased focus on qualitative understanding and history and philosophy of science (HPS) aspects. We have studied an innovative approach implementing such features in quantum physics in traditional upper secondary physics classrooms in Norway. Data consists of 11 focus groups with 58 participants from 11 physics classes, collected in 2013–2016 and analyzed thematically. Using the the implied student (Ulriksen, ) as an analytical lens, we study the experiences of actual physics students against the student “implied” by the innovative approach. The findings suggest that students struggled where the new approach holds implicit expectations that differ greatly from how students are expected to “do physics” in traditional classrooms. For example, students found it difficult to monitor their performance in the absence of calculations and factual answers. However, students easily adopted visualizations as a new tool for reaching the familiar goal of content knowledge. HPS aspects motivated students, but were not necessarily seen as learning goals in their own right. There is a need for better alignment between learning activities, learning goals and assessment in innovations, and for making implicit expectations explicit so that students know what “doing physics” successfully entails.
Synthesis of Thiazolopyrimidines via Annulation of N‐(4,6‐Diaryl‐2‐thioxo‐1,2,3,6‐tetrahydropyrimidin‐4‐yl)phenyl)aryl‐sulfonamides
Authors: Bahekar Sandeep P. , Chandak Hemant S 
Published: March 2018

AbstractA series of 5,7‐diaryl‐5H‐thiazolo[3, 2‐a]pyrimidin‐3(2H)‐ones (4 a‐4 r) bearing sulfonamide scaffold have been synthesized by cyclocondensation of bromoacetic acid and N‐(4,6‐diaryl‐2‐thioxo‐1,2,3,6‐tetrahydropyrimidin‐4‐yl)phenyl)aryl‐sulfonamides (3 a‐3ab). Compounds 3 a‐3ab have been synthesized by cyclocondensation of sulfonamide chalcones (1) and thiourea. Acetic acid: acetate buffer system and temperature of the reaction system played an important role in conversion of 3 to 4. The synthesized compounds were evaluated for their in vitro anticancer activities against the strain of human breast cancer cell line MCF‐7. Compounds 3 e, 3 p, 4 h and 4 k with GI50 below 80 μM were found to be moderately cytotoxic against MCF‐7.
Copper‐Catalyzed Click Synthesis of Novel 1,2,3‐Triazole‐Linked Pyrimidines
Authors: Bakherad Mohammad , Rezaeimanesh Fatemeh , Nasr‐Isfahani Hossein 
Published: March 2018

AbstractA series of novel 1,2,3‐triazole‐functionalized pyrimidines were prepared by the reaction of 4‐propargyl‐substituted‐5‐bromo‐2‐chloro‐6‐methylpyrimidine with aryl azides via copper‐catalyzed azide‐alkyne cycloaddition reactions in the presence of phenylenediamine, as a ligand. This method offers the advantages of mild experimental conditions, operational simplicity, and good to high reaction yields. Furthermore, the synthesized compounds were screened against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginosa, and Bacillus subtilis.
Synthesis, Antibacterial Activity and Molecular Docking of Substituted Naphthyridines as Potential DNA Gyrase Inhibitors
Authors: Omar Farghaly A. , Abelrasoul Mariam , Sheha Mahmoud M. , Hassan Hoda Y. , Ibrahiem Yasser Musa. 
Published: March 2018

AbstractA series of naphthyridine‐3‐thiosemicarbazide 7,8(a–e) and the corresponding cyclized analogs, naphthyridine‐3‐(1,3,4‐oxadiazoles) 9,10(a–e) were synthesized through modification of the COOH in nalidixic acid (NA) and its 6‐bromo analogue, as new chemical entities (NCE) with enhanced antimicrobial potential. The compounds were screened for antibacterial activity against Gram positive (G+ve) strains (S. aureus, B. cereus); Gram negative (G‐ve) (E. coli, K. pneumonia, P. aeruginosa) and Mycobac. smegmatis. Compounds 7 b,c and 9 b,d displayed the highest activity against S. aureus (minimal inhibitory concentration; MIC ∼ 6–7 mM), whereas B. cereus was found to be more susceptible to the brominated oxadiazoles 10 b,d,e (MIC∼ 5.5‐5.9 mM). Moreover, 10 b,c,d exhibit similar MIC values against K. pneumonia and M. smegmatis. This demonstrates that bromination of the naphtyridone skeleton results in broader spectrum and enhanced antibacterial profile. In addition, the aryl substituted thioemicarbazides 7 c,d,e showed inhibitory effect of the growth of M. smegmatis at MIC ∼ 5.4‐7.1 mM. Molecular docking to DNA‐gyrase cleavage complex of S. aureus, Mycobac. (mTB) and Top. IV of K. pneumonia revealed similar binding poses to the co‐crystallized quinolone ligands and indicate good correlation of the binding energy (ΔG) with the observed MIC values of the active compounds. Consequently, DNA‐gyrase assay was proposed and executed. Most prominent DNA‐gyrase inhibition showed by the naphthyridinyl‐3‐thiosemicarbazides, 7 c and 8 e (IC50: 1.73 and 4.46 μg/mL respectively); and the oxadiazoles 9 b and 10 d (IC50: 3.36 and 3.89 μg/mL respectively). Assessment of drug‐likeness characteristics illustrates that the synthesized compounds showed agreement to Lipinsiki's and Veper's parameters. The study could offer an exceptional framework that may lead to the discovery of new potent antimicrobial agents.
The relational view revisited: A dynamic perspective on value creation and value capture
Authors: Dyer Jeffrey H. , Singh Harbir , Hesterly William S. 
Published: March 2018

Research Summary:This paper extends the relational view to offer a dynamic perspective on the factors that drive value creation and value capture over the alliance life cycle. We argue that access to complementary resources provides an initial rationale for forming alliances, but benefits from complementarity can attenuate over time. Indeed, viewed dynamically, factors that often lead to higher value creation—informal trust, repeated ties, customized assets—may also lead to diminished alliance performance. We highlight interdependence between the complementary resources of partners asthecritical factor determining the pattern of alliance value creation, notably how quickly alliances generate value and how quickly they are likely to dissolve. We identify factors, both internal and external to the alliance, that trigger diminished value creation and increased competition for value capture among partners.Managerial Summary:The “relational view” perspective has shown that firms create value in alliances when they identify partners with complementary resources, when they build high levels of informal trust and they share knowledge and make investments that are customized to the partner. The level of resource interdependence in alliances determines how quickly alliances can reach their potential in value creation and how quickly they are likely to dissolve. Viewed dynamically, factors that often lead to higher value creation—like informal trust, repeated ties, customized assets—may also lead to diminished alliance performance. Finally, a number of factors both internal to and external to an alliance may trigger competition between the partners within an alliance to capture the value created by the alliance and also diminish the value created within the alliance.
Fingerprint‐Inspired Flexible Tactile Sensor for Accurately Discerning Surface Texture
Authors: Cao Yudong , Li Tie , Gu Yang , Luo Hui , Wang Shuqi , Zhang Ting 
Published: March 2018

AbstractInspired by the epidermal–dermal and outer microstructures of the human fingerprint, a novel flexible sensor device is designed to improve haptic perception and surface texture recognition, which is consisted of single‐walled carbon nanotubes, polyethylene, and polydimethylsiloxane with interlocked and outer micropyramid arrays. The sensor shows high pressure sensitivity (−3.26 kPa−1 in the pressure range of 0−300 Pa), and it can detect the shear force changes induced by the dynamic interaction between the outer micropyramid structure on the sensor and the tested material surface, and the minimum dimension of the microstripe that can be discerned is as low as 15 µm × 15 µm (interval × width). To demonstrate the texture discrimination capability, the sensors are tested for accurately discerning various surface textures, such as the textures of different fabrics, Braille characters, the inverted pyramid patterns, which will have great potential in robot skins and haptic perception, etc.
ZIF‐8 with Ferrocene Encapsulated: A Promising Precursor to Single‐Atom Fe Embedded Nitrogen‐Doped Carbon as Highly Efficient Catalyst for Oxygen Electroreduction
Authors: Wang Jinpeng , Han Guokang , Wang Liguang , Du Lei , Chen Guangyu , Gao Yunzhi , Ma Yulin , Du Chunyu , Cheng Xinqun , Zuo Pengjian , Yin Geping 
Published: March 2018

AbstractThe oxygen reduction reaction (ORR) plays an important role in the fields of energy storage and conversion technologies, including metal–air batteries and fuel cells. The development of nonprecious metal electrocatalysts with both high ORR activity and durability to replace the currently used costly Pt‐based catalyst is critical and still a major challenge. Herein, a facile and scalable method is reported to prepare ZIF‐8 with single ferrocene molecules trapped within its cavities (Fc@ZIF‐8), which is utilized as precursor to porous single‐atom Fe embedded nitrogen‐doped carbon (Fe–N–C) during high temperature pyrolysis. The catalyst shows a half‐wave potential (E1/2) of 0.904 V, 67 mV higher than commercial Pt/C catalyst (0.837 V), which is among the best compared with reported results for ORR. Significant electrochemical properties are attributed to the special configuration of Fc@ZIF‐8 transforming into a highly dispersed iron–nitrogen coordination moieties embedded carbon matrix.
Engineering Single‐Atom Cobalt Catalysts toward Improved Electrocatalysis
Authors: Wan Gang , Yu Pengfei , Chen Hangrong , Wen Jianguo , Sun Cheng‐jun , Zhou Hua , Zhang Nian , Li Qianru , Zhao Wanpeng , Xie Bing , Li Tao , Shi Jianlin 
Published: March 2018

AbstractThe development of cost‐effective catalysts to replace noble metal is attracting increasing interests in many fields of catalysis and energy, and intensive efforts are focused on the integration of transition‐metal sites in carbon as noble‐metal‐free candidates. Recently, the discovery of single‐atom dispersed catalyst (SAC) provides a new frontier in heterogeneous catalysis. However, the electrocatalytic application of SAC is still subject to several theoretical and experimental limitations. Further advances depend on a better design of SAC through optimizing its interaction with adsorbates during catalysis. Here, distinctive from previous studies, favorable 3d electronic occupation and enhanced metal–adsorbates interactions in single‐atom centers via the construction of nonplanar coordination is achieved, which is confirmed by advanced X‐ray spectroscopic and electrochemical studies. The as‐designed atomically dispersed cobalt sites within nonplanar coordination show significantly improved catalytic activity and selectivity toward the oxygen reduction reaction, approaching the benchmark Pt‐based catalysts. More importantly, the illustration of the active sites in SAC indicates metal‐natured catalytic sites and a media‐dependent catalytic pathway. Achieving structural and electronic engineering on SAC that promotes its catalytic performances provides a paradigm to bridge the gap between single‐atom catalysts design and electrocatalytic applications.
Detection of Individual Molecules and Ions by Carbon Nanotube‐Based Differential Resistive Pulse Sensor
Authors: Peng Ran , Tang Xiaowu Shirley , Li Dongqing 
Published: March 2018

AbstractThis paper presents a new method of sensing single molecules and cations by a carbon nanotube (CNT)‐based differential resistive pulse sensing (RPS) technique on a nanofluidic chip. A mathematical model for multichannel RPS systems is developed to evaluate the CNT‐based RPS signals. Individual cations, rhodamine B dye molecules, and ssDNAs are detected successfully with high resolution and high signal‐to‐noise ratio. Differentiating ssDNAs with 15 and 30 nucleotides are achieved. The experimental results also show that translocation of negatively charged ssDNAs through a CNT decreases the electrical resistance of the CNT channel, while translocation of positively charged cations and rhodamine B molecules increases the electrical resistance of the CNT. The CNT‐based nanofluidic device developed in this work provides a new avenue for single‐molecule/ion detection and offers a potential strategy for DNA sequencing.
Data‐Matrix Technology for Multiparameter Monitoring of Cell Cultures
Authors: Barbalinardo Marianna , Gentili Denis , Lazzarotto Francesca , Valle Francesco , Brucale Marco , Melucci Manuela , Favaretto Laura , Zambianchi Massimo , Borrachero‐Conejo Ana I. , Saracino Emanuela , Benfenati Valentina , Natalini Davide , Greco Pierpaolo , Di Carlo Maria Giovanna , Foschi Giulia , Cavallini Massimiliano 
Published: March 2018

AbstractA data‐matrix (DM)‐technology approach in cell biology is implemented as an efficient method for the multiparameter monitoring of cell cultures. The proposed method takes advantage of the know‐how developed for fault tolerance in digital information technology by measuring the amount of errors induced by intervening cells upon checking a DM code placed behind them. It gives continuous access to several quantitative parameters of the observed culture, such as cell coverage, mean size, viability, and transfection efficiency.
Estimating interspecific economic risk of bird strikes with aircraft
Authors: DeVault Travis L. , Blackwell Bradley F. , Seamans Thomas W. , Begier Michael J. , Kougher Jason D. , Washburn Jenny E. , Miller Phyllis R. , Dolbeer Richard A. 
Published: March 2018

ABSTRACTThe International Civil Aviation Organization promotes prioritization of wildlife management on airports, among other safety issues, by emphasizing the risk of wildlife–aircraft collisions (strikes). In its basic form, strike risk comprises a frequency component (i.e., how often strikes occur) and a severity component reflecting the cost of the incident. However, there is no widely accepted formula for estimating strike risk. Our goal was to develop a probabilistic risk metric that is adaptable for airports to use. Our specific objectives were to 1) update species‐specific, relative hazard scores (i.e., the likelihood of aircraft damage or effect on flight when strikes occur) using recent U.S. Federal Aviation Administration (FAA) wildlife strike data (2010–2015); 2) develop 4 a priori risk models, reflecting species‐specific strike data and updated relative hazard scores; 3) test these models against independent data (monetary costs associated with strikes); and 4) apply our best model to strike data from 4 large, FAA‐certificated airports to illustrate its application at the local level. Our best‐fitting risk model included an independent variable that was an interaction of quadratic transformed relative hazard score and number of wildlife strikes (r2 = 0.74). Top species in terms of estimated risk nationally were red‐tailed hawk (Buteo jamaicensis), Canada goose (Branta canadensis), turkey vulture (Cathartes aura), rock pigeon (Columba livia), and mourning dove (Zenaida macroura). We found substantial overlap among the top 5 riskiest species locally across 3 of 4 airports considered, illustrating the degree of site‐specific differences that affect risk. Strike risk is dynamic; therefore, future work on risk estimation should allow for model adjustment to reflect ongoing wildlife management actions at airports that could influence future strike risk. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.
Size‐dependent predation and correlated life history traits alter eco‐evolutionary dynamics and selection for faster individual growth
Authors: DeLong John P. , Luhring Thomas M. 
Published: March 2018

AbstractAge at maturation is a key life history trait influencing individual fitness, population age structure, and ecological interactions. We investigated the evolution of age at maturity through changes in the von Bertalanffy growth constant for organisms with a simple juvenile‐adult life history. We used Gillespie eco‐evolutionary models to uncover the role of predation in driving the evolution of the growth constant when eco‐evolutionary dynamics are present. We incorporated both size‐independent and size‐dependent predation into our models to generate differences in selection and dynamics in the system. Our results generally support the idea that faster ontogenetic growth is beneficial when populations are growing but that predation tends to have little effect on age at maturity unless there are trade‐offs with other life history traits. In particular, if faster ontogenetic growth comes at the cost of fecundity, our results suggest that predation selects for intermediate levels of growth and fecundity. Eco‐evolutionary dynamics influenced the nature of selection only when growth was linked to fecundity. We also found that predators that increasingly consume larger prey tend to have higher population sizes due to the greater energy intake from larger prey, but the growth rate‐fecundity trade‐off reversed this pattern. Overall, our results suggest an important role for interactions between size‐dependent foraging and life‐history trade‐offs in generating varying selection on age at maturity through underlying growth traits.