bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burden of itch in ichthyosis: a multicentre study in 94 patients
Authors: De Palma A.M. , Mazereeuw‐Hautier J. , Giehl K. , Hernández‐Martin A. , Merlos M. , Moons P. , Morren M.A. 
Published: May 2019

AbstractBackgroundFrom clinical experience, we know that itch is a major concern for many ichthyosis patients. Nonetheless, no previous studies specifically addressed the issue of itch in ichthyosis.ObjectiveThe objective of this study was to specifically address the burden of itch and all its dimensions in ichthyosis patients.MethodsNinety‐four ichthyosis patients from four different centres were recruited to participate in this cross‐sectional, questionnaire‐based study. All participants completed the Leuven Itch Scale, a multidimensional self‐report instrument that quantifies the frequency, duration, severity, distress, consequences and surface area of itch.ResultsParticipants included 18 keratinopathic types, 55 autosomal recessive congenital ichthyoses, 11 X‐linked recessive ichthyoses (XLRIs), 6 Netherton's ichthyoses, 1 Sjögren–Larsson type, 1 Iocrin ichthyosis and 2 unknown subtypes. Itch occurred in 93% of all patients. In patients with itch, 63% reported that it was often or always present, although most itch episodes were short in duration. Itch, in all its dimensions, was worst in patients with Netherton syndrome. Patients with XLRI had in general a lower itch profile. About half of all ichthyosis patients reported to experience flares during a change in weather, in a hot environment or in stressful situations, whereas a cold environment led to itch in only 26% of patients. The most significant consequences of itching were lesions from scratching, difficulties in falling asleep, bad mood and loss of concentration.ConclusionsItch is a major concern in patients with ichthyosis, with significant impact on daily life. Research on future treatments should therefore take itch into consideration and itch should be evaluated in clinical studies. Among the studied subgroups, Netherton patients experienced the most severe consequences.
Mechanical properties, thermal stability, and solubility of sheep bone collagen–chitosan films
Authors: Hou Chengli , Gao Lingling , Wang Zhenyu , Rao Weili , Du Manting , Zhang Dequan 
Published: May 2019

AbstractThis study aimed to prepare sheep bone collagen–chitosan (BC‐CS) blend films and to characterize their film‐forming properties and structure. The blend films were prepared with different blend ratio of collagen and CS (BC:CS = 100:0, 60:40, 50:50, 40:60, and 0:100) with skin gelatin‐chitosan (SG‐CS) film used as a control. The results showed that the BC film became smoother, tougher, and more transparent when CS was added. The addition of CS significantly increased the tensile strength of the BC film. Elongation at break of the BC film decreased when the addition of CS was more than 50%. Compared with the BC film, the light barrier properties of the blended films increased in the ultraviolet region. The blend films exhibited increased thermal stability and decreased water solubility when compared with the BC film, but their permeability to water vapor increased undesirably. Fourier transform infrared spectroscopy results confirmed the formation of intermolecular hydrogen bonds between BC and CS in the blends. Conclusively, the film‐forming properties of BC‐CS blend films have the potential to be used for food packaging.Practical ApplicationsThe sheep bone collagen–chitosan blend film was fairly transparent and possessed good mechanical properties, which might be suitable for food packaging. This study can provide some reference for future development of bone collagen films for industrial application and bring forth new ideas for the utilization of animal bone coproducts.
Improving the infrared drying and rehydration of potato slices using simple approaches: Perforations and ethanol
Authors: Rojas Meliza L. , Silveira Isabela , Augusto Pedro E. D. 
Published: May 2019

AbstractThe objective of this work was use ethanol and perforations as simple approaches to improve the infrared drying and rehydration of potato slices. Perforations were performed to study the effect of promoting routes to capillarity flow, while ethanol was impregnated in the samples to evaluate the effect of Marangoni flow. All pretreatments reduced the drying time compared to control treatment. However, a great time reduction was observed with P + E pretreatment: The synergistic combination of both treatments increased the drying rate in more than four times, reducing both drying time and the necessary energy by 44%. The samples with perforations (P and P + E) increased their rehydration rate as well as the water retention capacity. However, the pretreated samples with ethanol shows poor rehydration properties. Possible mechanisms were discussed. These results show simple approaches to enhance food drying and rehydration.Practical ApplicationsDrying is an ancient unit operation to obtain safe and stable food products. However, some challenges still face food process engineers, such as the long processing time and the low rehydration capacity. Consequently, different technologies have been explored to enhance food drying, such as pulsed electric fields, high pressure, and ultrasound. However, although interesting and effective, some of that approaches can be complicated or even expensive when considering the reality of drying vegetables such as fruits and starchy products, limiting their application. Therefore, this work purposes a simple but efficient technique based on the use of ethanol and the creation of channels through perforations to improve the infrared drying of potato slices, also evaluating the rehydration properties. Our results show that simple operations could be performed to create routes to water flow (through mechanical perforations) combined with drying accelerator (ethanol), improving both drying and rehydration of food products.
Impact of obesity and metabolic abnormalities on the risk of metachronous colorectal neoplasia after polypectomy in men
Authors: Kim Nam Hee , Jung Yoon Suk , Park Jung Ho , Park Dong Il , Sohn Chong Il 
Published: May 2019

AbstractBackground and AimObesity and metabolic syndrome are well‐known risk factors for the development of metachronous colorectal neoplasia (CRN). However, data on the risks of metachronous CRN among subgroups according to obesity and metabolic status are scarce. Therefore, we aimed to compare the risk of metachronous CRN among men with different obesity and metabolic status.MethodsIn total, 8059 asymptomatic men who underwent ≥ 1 adenoma removal between 2010 and 2014 and follow‐up colonoscopic surveillance until 2017 were categorized into four groups according to obesity and metabolic status: metabolically healthy non‐obese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy non‐obese (MUNO), and metabolically unhealthy obese (MUO).ResultsOf the 8059 men, 2389 (29.6%), 351 (4.4%), 1986 (24.6%), and 3333 (41.4%) subjects were assigned to the MHNO, MHO, MUNO, and MUO groups, respectively. The mean surveillance interval was 3.5 ± 1.4 years. Compared to the MHNO group, the risk of metachronous advanced CRN was significantly increased in the MUO group (adjusted hazard ratio [HR] = 1.50; 95% confidence interval [CI]: 1.02–2.19), but not in the MHO and MUNO groups, while the risk of metachronous overall CRN significantly increased in the MUNO (adjusted HR = 1.12; 95% CI: 1.01–1.24) and MUO groups (adjusted HR = 1.17; 95% CI: 1.07–1.29), but not in the MHO group.ConclusionsMen who had both obesity and poor metabolic health were found to be at an increased risk of metachronous advanced CRN, suggesting that MUO men may need to undergo more intensive surveillance colonoscopy after polypectomy.
NIACE score refines the overall survival of hepatocellular carcinoma by Barcelona clinic liver cancer staging
Authors: Su Tung‐Hung , Liao Sih‐Han , Hong Chun‐Ming , Liu Chun‐Jen , Tseng Tai‐Chung , Liu Chen‐Hua , Yang Hung‐Chih , Chen Pei‐Jer , Chen Ding‐Shinn , Chen Chi‐Ling , Adhoute Xavier , Bourlière Marc , Kao Jia‐Horng 
Published: May 2019

AbstractBackground and AimThe NIACE score provides prognostic values for hepatocellular carcinoma (HCC) in European studies. We aim to evaluate the prognostic value of the NIACE score in Asian patients.MethodsPatients with HCC were retrospectively enrolled from a tertiary medical center in Taiwan during 2009–2014, and their clinical information were collected. The NIACE score was calculated according to the Nodular numbers, tumor Infiltration, Alpha‐fetoprotein level, Child–Pugh score, and Eastern Cooperative Oncology Group score. The prognostic values of NIACE score for overall survival according to individual treatment and the Barcelona clinic liver cancer (BCLC) staging were analyzed.ResultsA total of 468 patients were included with a median follow‐up of 30 months. A greater NIACE score correlated with lower median survival and higher BCLC staging. Regardless of treatment modalities, NIACE scores (0, 1–1.5, 2.5–3, and 4–7) significantly predicted survival between groups (log–rank P < 0.001). Specifically, NIACE score (0, 1–1.5, 2.5–3, and 4–7) significantly predicted survival in patients receiving transarterial chemoembolization (log–rank P < 0.001). NIACE score 1, 2.5, and 4 further distinguished overall survival in BCLC A, B, and C patients, respectively (all log–rank P < 0.01). After adjustment of the confounders and the BCLC staging, NIACE score of 2.5–3 and 4–7 (vs 0) had a significantly increased risk of mortality with a hazard ratio of 4.04 (95% confidence interval: 2.14–7.64, P < 0.001) and 7.45 (95% confidence interval: 3.22–17.23, P < 0.001), respectively.ConclusionsThe NIACE score helps refine differential prognosis among BCLC A, B, and C subgroups of Asian patients with HCC, especially in those receiving transarterial chemoembolization.
Potential of Helicobacter pylori‐uninfected signet ring cell carcinoma to invade the submucosal layer
Authors: Yorita Naoki , Ito Masanori , Boda Tomoyuki , Kotachi Takahiro , Nagasaki Naoko , Abuduwaili Madina , Hata Kosaku , Hiyama Yuichi , Oka Shiro , Yoshihara Masaharu , Kitadai Yasuhiko , Tanaka Shinji , Chayama Kazuaki 
Published: May 2019

AbstractBackground and AimThe typical histology of Helicobacter pylori‐uninfected gastric cancer is signet ring cell carcinoma (SRCC) localized in the mucosal layer, but the potential of these SRCCs to invade the submucosal layer is unclear. This study aimed to investigate the clinicopathological characteristics of SRCC in H. pylori‐uninfected patient and its prevalence in diffuse‐type gastric cancer (DGC) within Japan.MethodsWe enrolled consecutive pure DGC patients diagnosed with the disease either localized in the mucosal layer or with submucosal invasion. H. pylori infection was investigated, and the patients were divided into three groups according to histological types: pure SRCC, SRCC with poorly differentiated adenocarcinoma (PDA), and pure PDA.ResultsOf the 345 pure DGC patients, 132 (38%), 127 (37%), and 86 (25%) had pure SRCC, SRCC with PDA, and pure PDA histologies, respectively. The prevalence of H. pylori infection and the SM ratio were significantly lower in the pure SRCC group than other groups (P < 0.01). Twenty‐two (6.4%) patients, including two with submucosal invasion, were negative for H. pylori and had mucosal SRCC component in the cancer lesions. Of the 259 SRCC cases (pure SRCC or SRCC + PDA), H. pylori‐uninfected cases had different clinicopathological characteristics compared with H. pylori‐positive cases. Particularly, the ratio of patients with submucosal invasive SRCC was significantly lower in the H. pylori‐uninfected gastric cancer group than in those with H. pylori infection.ConclusionHelicobacter pylori‐uninfected gastric cancer is not rare among pure DGC patients in Japan. SRCC in patients without H. pylori infection is less likely to be invasive.
Understanding mothers' perception of child's illness: Adapting the CONNECT Instrument for pediatrics
Authors: Magner Kristin , Bragg Dawn , Treat Robert , Lee K. Jane 
Published: May 2019

AbstractAims and objectivesTo adapt the CONNECT Instrument for use in the paediatric population, to assess validity of this instrument after its adaptation and to assess concordance between mothers' perception of their child's illness and providers' understanding of mothers' perceptions.BackgroundThe CONNECT Instrument (Patient Education and Counseling, 73, 2008, 232–239) was validated in an adult outpatient population to characterise both patients' perspectives and physicians' understanding of their patients' perspectives for several dimensions of the illness experience. However, this did not include the paediatric population or advanced practice providers.DesignA two‐part prospective, cross‐sectional, observational study to assess the validity of CONNECT for Pediatrics and to assess perception of illness.MethodsThe CONNECT Instrument (Patient Version) was adapted from its original form and modified to CONNECT for Pediatrics to facilitate use in the inpatient paediatric population. Eighty‐five participants were enrolled including mothers, advanced practice providers and physicians from 2013–2014 during a child's scheduled admission to a paediatric epilepsy monitoring unit. Principal components analysis and inter‐item reliability were analysed, and differences in the six mean domain scores were assessed using repeated measures analysis of variance (RM‐ANOVA). Reporting of this research adheres to the STROBE guidelines (See Appendix S1).ResultsOur analysis indicated that the modifications made provided a relatively valid and reliable instrument. There were overall statistically significant differences between the mother and physician groups, specifically in the domains of meaning and preference for partnership.ConclusionsPaediatric advanced practice providers and physicians do have an understanding of mothers' perception of illness.Relevance to clinical practiceThe ability of physicians and advanced practice providers to understand mothers' perceptions of illness is increasingly important in a changing healthcare environment. CONNECT for Pediatrics facilitates the identification of mothers' perception of their child's illness and provides the opportunity for paediatric advanced practice providers and physicians to understand parents’ perception of illness.
Association of maternal vitamin D deficiency and infants' neurodevelopmental status: A cohort study on vitamin D and its impact during pregnancy and childhood in Indonesia
Authors: Dhamayanti Meita , Noviandhari Anindita , Supriadi Stephani , Judistiani Raden TD , Setiabudiawan Budi 
Published: May 2019

AimVitamin D deficiency in early pregnancy may cause the disruption of fetal brain development and neurodevelopmental function. This study aimed to explore the extent of neurodevelopment disruption could be associated with maternal vitamin D deficiency.MethodsA cohort study was conducted in Sukabumi and Waled, West Java, Indonesia, beginning in July 2016. Maternal serum 25(OH)‐vitamin D was measured between 10 and 14 weeks of gestational age. Child development was measured using the Ages and Stages Questionnaire‐3 (ASQ‐3) at age 3, 6 and 12 months.ResultsA total of 141 mother–infant pairs participated. One pair was excluded due to anencephaly of the infant. Vitamin D deficiency was found in 27 (19%) mothers, but delays occurred in gross motor function among 104 (76.1%) infants and in problem‐solving functions among 61 (43.7%) infants at 3 months old. In general, the mean ASQ score at ages 3 and 6 months were lower among infants whose mothers had a vitamin D deficiency. The mean ASQ score for gross motor function at age 3 months was found to be significantly lower among these infants (31.5 vs. 37.9; P = 0.02), with increased risk for delayed motor function at age 3 months (relative risk (95% confidence interval) = 1.22 (1.09–1.49); P = 0.03).ConclusionNeurodevelopmental function disruptions among infants whose mothers had vitamin D deficiency during pregnancy were reflected in lower ASQ scores, in which gross motor function was significantly impaired at 3 months of age.
Young people's experiences of brief inpatient treatment for anorexia nervosa
Authors: Thabrew Hiran , Mairs Rebecca , Taylor‐Davies Genevieve 
Published: May 2019

AimTo understand the experiences of young people with anorexia admitted to hospital for brief stays and to inform the design of contemporary inpatient treatment to better suit their needs in the context of a significant shift in practice from longer hospital admissions to shorter stays.MethodsA qualitative study was undertaken with young people within a few months of discharge from a specialist inpatient eating disorder service, Auckland, New Zealand. Audiotaped, semi‐structured interviews were conducted with participants within a few months of their discharge from hospital and transcribed for coding.ResultsNine young people, all female, of mixed ethnicity (seven New Zealand European and two Asian) and aged between 15 and 17 years participated in the study. Five main themes were identified from the data, namely: (i) benefits of admission; (ii) sources of stress; (iii) control and power; (iv) having a voice and being heard; and (v) comparison of oneself with others.ConclusionsAlthough many of the benefits and challenges associated with brief treatment were similar to those during longer inpatient care, the impact of certain issues was more strongly experienced by participants and highlighted the need for greater attention to be paid to making young people feel better supported and included during predominantly medically focused admissions.
Nitrogen maintenance requirements and potential for nitrogen retention of pullets in growth phase
Authors: Soares Letícia , Sakomura Nilva Kazue , de Paula Dorigam Juliano Cesar , Liebert Frank , Quintino do Nascimento Mariana , Kochenborger Fernandes João Batista 
Published: May 2019

AbstractExperiments were conducted to estimate daily N maintenance requirements (NMRs) and the genetic potential for daily N retention (NRmaxT) of pullets in growth phase. Three nitrogen balance trials were conducted, and a total of 48 Hy‐line W‐36 pullets were used in each trial in age periods (starter: 14–28, grower: 56–70 and developer: 98–112 days). The treatments consisted of six graded levels of nitrogen in the diets (L1 = 8, L2 = 16, L3 = 24, L4 = 32, L5 = 40 and L6 = 48 g N/kg of feed), formulated using the dilution technique. The regression analyses between nitrogen intake and nitrogen excretion were performed to fit the exponential function and to determine the NMR. The daily NMRs that were estimated at 294, 331 and 355 mg/BWkg0.67 for the initial, grower and developer periods, respectively, were applied for further calculation of NRmaxT as the threshold value of the function between N intake and daily N balance. The NRmaxT was estimated by a statistical procedure following several iteration steps by the Levenberg–Marquardt algorithm until the sum of the squares of the residual was minimized. The NRmaxT was estimated at 3,200, 2,633 and 1,826 mg/BWkg0.67 for starter, grower and developer periods respectively. The determined model parameters were the precondition for modelling of the amino acid requirement based on an exponential N‐utilization model and depended on performance and dietary amino acid efficiency. This procedure will be further developed and applied in the subsequent study.
High salt stress in the upper part of floating mats of Ulva prolifera, a species that causes green tides, enhances non‐photochemical quenching
Authors: Zheng Zhenbing , Gao Shan , Wang Guangce 
Published: May 2019

Salt stress is a major abiotic stress factor that can induce many adverse effects on photosynthetic organisms. Plants and algae have developed several mechanisms that help them respond to adverse environments. Non‐photochemical quenching (NPQ) is one of these mechanisms. The thalli of algae in the intertidal zone that are attached to rocks can be subjected to salt stress for a short period of time due to the rise and fall of the tide. Ulva prolifera causes green tides and can form floating mats when green tides occur and the upper part of the thalli is subjected to high salt stress for a long period of time. In this study, we compared the Ulva prolifera photosynthetic activities and NPQ kinetics when it is subjected to different salinities over various periods of time. Thalli exposed to a salinity of 90 for 4 d showed enhanced NPQ, and photosynthetic activities decreased from 60 min after exposure up to 4 d. This indicated that the induction of NPQ in Ulva prolifera under salt stress was closely related to the stressing extent and stressing time. The enhanced NPQ in the treated samples exposed for 4 d may explain why the upper layer of the floating mats formed by Ulva prolifera thalli were able to survive in the harsh environment. Further inhibitor experiments demonstrated that the enhanced NPQ was xanthophyll cycle and transthylakoid proton gradient‐dependent. However, photosystem II subunit S and light‐harvesting complex stress‐related protein didn't over accumulate and may not be responsible for the enhanced NPQ.
Functional palatability enhancer improved growth, intestinal morphology, and hepatopancreas protease activity, replacing squid paste in white shrimp, Litopenaeus vannamei, diets
Authors: Zhu Tingting , Morais Sofia , Luo Jiaxiang , Jin Min , Lu You , Le Yirong , Zhou Qicun 
Published: May 2019

AbstractSquid visceral paste is a popular attractant and feeding stimulator supplement in shrimp feeds in China, but it often faces problems with fluctuating availability, cost, composition, and quality. An 8‐week experiment was performed to test a proprietary palatability enhancer as an alternative to squid paste in white shrimp feed. Seven diets were tested: a control diet with no supplementations; S1 and S3 diets supplemented with squid paste at 1 or 3%, respectively; S1+PE0.1 and S1+PE0.15 supplemented with both 1% squid paste and the palatability enhancer at either 0.1 or 0.15%, respectively; and finally PE0.1 and PE0.15 supplemented only with the palatability enhancer at 0.1 or 0.15%, respectively. The results showed a trend for increased feed intake and weight gain when squid paste was added to the diet compared to the control, but this was worsened by raising the inclusion level from 1 to 3%. The inclusion of the PE, in combination with squid paste or alone at 0.15%, led to a significantly higher growth, and a feeding stimulation effect was also indicated, with PE0.1 and PE0.15 having a higher feed intake than the control. A further beneficial effect was a significant increase in protease activity in the hepatopancreas in the S1+PE0.15, PE0.1, and PE0.15 treatments compared to the control. In addition, a significant increase in the height of the intestinal mucosal folds was observed in PE0.15, followed by PE0.1. The results demonstrated the potential to replace or reduce squid visceral paste in shrimp diets by supplementing with a PE with functional effects beyond feeding stimulation.