bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival: an epigenomic–smoking interaction analysis
Authors: Zhang Ruyang , Lai Linjing , Dong Xuesi , He Jieyu , You Dongfang , Chen Chao , Lin Lijuan , Zhu Ying , Huang Hui , Shen Sipeng , Wei Liangmin , Chen Xin , Guo Yichen , Liu Liya , Su Li , Shafer Andrea , Moran Sebastian , Fleischer Thomas , Bjaanæs Maria Moksnes , Karlsson Anna , Planck Maria , Staaf Johan , Helland Åslaug , Esteller Manel , Wei Yongyue , Chen Feng , Christiani David C. 
Published: March 2019

Smoking cessation prolongs survival and decreases mortality of patients with non‐small‐cell lung cancer (NSCLC). In addition, epigenetic alterations of some genes are associated with survival. However, potential interactions between smoking cessation and epigenetics have not been assessed. Here, we conducted an epigenome‐wide interaction analysis between DNA methylation and smoking cessation on NSCLC survival. We used a two‐stage study design to identify DNA methylation–smoking cessation interactions that affect overall survival for early‐stage NSCLC. The discovery phase contained NSCLC patients from Harvard, Spain, Norway, and Sweden. A histology‐stratified Cox proportional hazards model adjusted for age, sex, clinical stage, and study center was used to test DNA methylation–smoking cessation interaction terms. Interactions with false discovery rate‐q ≤ 0.05 were further confirmed in a validation phase using The Cancer Genome Atlas database. Histology‐specific interactions were identified by stratification analysis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) patients. We identified one CpG probe (cg02268510SIPA1L3) that significantly and exclusively modified the effect of smoking cessation on survival in LUAD patients [hazard ratio (HR)interaction = 1.12; 95% confidence interval (CI): 1.07–1.16; P = 4.30 × 10–7]. Further, the effect of smoking cessation on early‐stage LUAD survival varied across patients with different methylation levels of cg02268510SIPA1L3. Smoking cessation only benefited LUAD patients with low methylation (HR = 0.53; 95% CI: 0.34–0.82; P = 4.61 × 10–3) rather than medium or high methylation (HR = 1.21; 95% CI: 0.86–1.70; P = 0.266) of cg02268510SIPA1L3. Moreover, there was an antagonistic interaction between elevated methylation of cg02268510SIPA1L3 and smoking cessation (HRinteraction = 2.1835; 95% CI: 1.27–3.74; P = 4.46 × 10−3). In summary, smoking cessation benefited survival of LUAD patients with low methylation at cg02268510SIPA1L3. The results have implications for not only smoking cessation after diagnosis, but also possible methylation‐specific drug targeting.
Surface Halogen Compensation for Robust Performance Enhancements of CsPbX3 Perovskite Quantum Dots
Authors: Yang Dandan , Li Xiaoming , Wu Ye , Wei Changting , Qin Zhengyuan , Zhang Chunfeng , Sun Zhiguo , Li Yuelei , Wang Yue , Zeng Haibo 
Published: March 2019

AbstractUnderstanding the subtle structure–property relationships of quantum dots (QDs) is essential for targeted modulation of optoelectronic properties, and the influences of surface defects of inorganic halide perovskite (HP) QDs are still not very clear. Here, the negative exciton trapping effects of surface halide vacancies (VX) on the photoluminescence quantum yield QY (PLQY) of HPQDs are determined by a detailed analysis of the optical parameters, exciton dynamics, and surface chemical states. Based on the fact that VX contribute greatly to nonradiative recombination processes, versatile in situ and postpassivation strategies are developed by constructing intact Pb–X octahedrons. High QYs for standard red CsPbBr1I2 (85%), green CsPbBr3 (96%), and blue CsPbBr1.3Cl1.7 (92%) emissions are achieved. The superiorities of the reduced VX are further demonstrated by high external quantum efficiency of 0.8% and a stable emission wavelength of the blue light‐emitting diodes. This study deepens the understanding of HPQDs and demonstrates the potential for the artificial control of the optical properties of HPQDs.
Preferential Siting of Aluminum Heteroatoms in the Zeolite Catalyst Al‐SSZ‐70
Authors: Berkson Zachariah J. , Hsieh Ming‐Feng , Smeets Stef , Gajan David , Lund Alicia , Lesage Anne , Xie Dan , Zones Stacey I. , McCusker Lynne B. , Baerlocher Christian , Chmelka Bradley F. 
Published: March 2019

AbstractThe adsorption and reaction properties of heterogeneous zeolite catalysts (e.g. for catalytic cracking of petroleum, partial oxidation of natural gas) depend strongly on the types and distributions of Al heteroatoms in the aluminosilicate frameworks. The origins of these properties have been challenging to discern, owing in part to the structural complexity of aluminosilicate zeolites. Herein, combined solid‐state NMR and synchrotron X‐ray powder diffraction analyses show the Al atoms locate preferentially in certain framework sites in the zeolite catalyst Al‐SSZ‐70. Through‐covalent‐bond 2D 27Al{29Si} J‐correlation NMR spectra allow distinct framework Al sites to be identified and their relative occupancies quantified. The analyses show that 94 % of the Al atoms are located at the surfaces of the large‐pore interlayer channels of Al‐SSZ‐70, while only 6 % are in the sub‐nm intralayer channels. The selective siting of Al atoms accounts for the reaction properties of catalysts derived from SSZ‐70.
Repositioning Chloride Transmembrane Transporters: Transport of Organic Ion Pairs
Authors: Grauwels Glenn , Valkenier Hennie , Davis Anthony P. , Jabin Ivan , Bartik Kristin 
Published: March 2019

AbstractGiven the biological importance of organic cations, the facilitated transport of organic ion pairs could find many applications. Calix[6]arene tris(thio)ureas, which possess a cavity that can accommodate primary ammonium ions, can not only act as carriers for Cl−/NO3− antiport but can also perform the cotransport of PrNH3Cl. Transport was monitored by fluorescence spectroscopy and the presence of the different species inside the vesicles was characterized by 1H and 35Cl NMR experiments involving shift reagents. The cotransport of PrNH3Cl was also observed by receptors deprived of a cavity, but the presence of the cavity conveys an advantage, as the cotransport by calix[6]arenes was observed to be more efficient than the Cl−/NO3− antiport, which is not the case with receptors without a cavity. The role played by the cavity was further highlighted by the disappearance of this advantage when using a bulky ammonium ion, which cannot be complexed within the cavity.
Direct Zinc Finger Protein Persulfidation by H2S Is Facilitated by Zn2+
Authors: Lange Mike , Ok Kiwon , Shimberg Geoffrey D. , Bursac Biljana , Markó Lajos , Ivanović‐Burmazović Ivana , Michel Sarah L. J. , Filipovic Milos R. 
Published: March 2019

AbstractH2S is a gaseous signaling molecule that modifies cysteine residues in proteins to form persulfides (P‐SSH). One family of proteins modified by H2S are zinc finger (ZF) proteins, which contain multiple zinc‐coordinating cysteine residues. Herein, we report the reactivity of H2S with a ZF protein called tristetraprolin (TTP). Rapid persulfidation leading to complete thiol oxidation of TTP mediated by H2S was observed by low‐temperature ESI‐MS and fluorescence spectroscopy. Persulfidation of TTP required O2 , which reacts with H2S to form superoxide, as detected by ESI‐MS, a hydroethidine fluorescence assay, and EPR spin trapping. H2S was observed to inhibit TTP function (binding to TNFα mRNA) by an in vitro fluorescence anisotropy assay and to modulate TNFα in vivo. H2S was unreactive towards TTP when the protein was bound to RNA, thus suggesting a protective effect of RNA.
Interplay of H‐Bonds with Aromatics in Isolated Complexes Identifies Isomeric Carbohydrates
Authors: Saparbaev Erik , Kopysov Vladimir , Yamaletdinov Ruslan , Pereverzev Aleksandr Y. , Boyarkin Oleg V. 
Published: March 2019

AbstractThe tremendous isomeric diversity of carbohydrates enables a wide range of their biological functions but makes the identification and study of these molecules difficult. We investigated the ability of intermolecular interactions to communicate structural specificity of carbohydrates to protonated aromatic molecules in non‐covalent complexes, isolated and cooled in the gas phase. Our study revealed that small structural differences between carbohydrate isomers of any type, including enantiomers, are accurately communicated by these interactions to aromatic molecules as detectable changes in their electronic excitation spectra. The specific response of the aromatics to the isomers of carbohydrates is fine‐tuned by the interplay of the various involved non‐covalent bonds. These findings enable the gas‐phase identification and relative quantification of any isomers of oligosaccharides in their solution mixtures using the 2D UV‐MS fingerprinting technique.
A Universal Strategy for Activating the Multicolor Room‐Temperature Afterglow of Carbon Dots in a Boric Acid Matrix
Authors: Li Wei , Zhou Wan , Zhou Zhishan , Zhang Haoran , Zhang Xuejie , Zhuang Jianle , Liu Yingliang , Lei Bingfu , Hu Chaofan 
Published: March 2019

AbstractCarbon dots (CDs) have attracted attention in metal‐free afterglow materials, but most CDs were heteroatom‐containing and the afterglow emissions are still limited to the short‐wavelength region. A universal approach to activate the room‐temperature phosphorescence (RTP) of both heteroatom‐free and heteroatom‐containing CDs was developed by one‐step heat treatment of CDs and boric acid (BA). The introduction of an electron‐withdrawing boron atom in composites can greatly reduce the energy gap between the singlet and triplet state; the formed glassy state can effectively protect the excited triplet states of CDs from nonradiative deactivation. A universal host for embedding CDs to achieve long‐lifetime and multi‐color (blue, green, green‐yellow and orange) RTP via a low cost, quick and facile process was developed. Based on their distinctive RTP performances, the applications of these CD‐based RTP materials in information encryption and decryption are also proposed and demonstrated.
A Monomeric Stannabenzene: Synthesis, Structure, and Electronic Properties
Authors: Kaiya Canon , Suzuki Katsunori , Yamashita Makoto 
Published: March 2019

AbstractA tin‐containing benzene, stannabenzene, was synthesized and isolated as a monomeric form. The X‐ray crystallographic analysis revealed the planar structure of the stannabenzene ring and unsaturated Sn−C and C−C bonds without bond alternation. Low‐field shifted NMR signals and negative nuclear‐independent chemical shifts (NICS) values are in agreement with the features of aromatic compounds. The narrow HOMO–LUMO gap of stannabenzene has been revealed by UV/Vis spectroscopy and electrochemistry.
Photoinitiator‐free photopolymerization of acrylate‐bismaleimide mixtures and their application for inkjet printing
Authors: Wagner Annika , Mühlberger Michael , Paulik Christian 
Published: March 2019

ABSTRACTThere is growing interest in using photoinitiator‐free systems in coating applications such as inkjet‐printing, because residual photoinitiator can alter the properties of the resulting polymer. Bismaleimides (BMI) offer the opportunity to polymerize acrylates without the addition of photoinitiators, as this class of molecules can serve both as polymerizable monomer and as photoinitiator together with electron donor systems, like vinyl ether monomers or acrylates. The UV‐induced copolymerization of a low‐molecular‐weight BMI with various acrylate monomers and oligomers without any photoinitiator was characterized. The BMI‐acrylate systems show comparable polymerization speeds to widely used acrylic systems with photoinitiator. Superior thermal stability as well as thermomechanical properties are achieved by enhancing acrylics with BMI. Such photoinitiator‐free systems lend themselves to be used for low‐migration coatings as well as for high‐temperature applications. Here, a characterization of selected BMI‐acrylate mixtures regarding their photocuring kinetics and their application as inks for inkjet printing is shown. © 2019 The Authors. Journal of Applied Polymer Science published by Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47789.
Carbon‐Coated and Interfacial‐Functionalized Mixed‐Phase MoxTi1−xO2‐δ Nanotubes as Highly Active and Durable PtRu Catalyst Support for Methanol Electrooxidation
Authors: Li Jia‐Long , Zhao Lei , Li Xi‐Fei , Hao Su‐E. , Wang Zhen‐Bo 
Published: March 2019

AbstractA synchronous carbon‐coating and interfacial‐functionalizing approach is proposed for the fabrication of Mo‐doped MoxTi1−xO2‐δ nanotubes (C@IF‐MTNTs) under mild hydrothermal reaction with subsequent annealing as advanced catalyst supports for PtRu nanoparticles (NPs) towards methanol electrooxidation. The carbonation of glucose and Mo‐doping takes place simultaneously at the interface of pristine anatase TiO2 nanotubes (TNTs), generating a unique concentric multilayered one‐dimensional (1D) structure with crystalline an anatase/rutile mixed‐phase TiO2 core and Mo‐functionalized interface and subsequently a carbon shell. The obtained PtRu/C@IF‐MTNTs catalyst exhibits an over 2 times higher mass activity with comparable durability than that of the unmodified PtRu/C@TNTs catalyst and over 1.7 times higher mass activity with over 20 % higher stability than that of PtRu/C catalyst. Such superior catalytic performance towards methanol electrooxidation is ascribed to the Mo‐functionalized interface, concentric multilayered 1D architecture, and anatase/rutile mixed‐phase core, which facilitates the charge transport through 1D structural support and electronic interaction between C@IF‐MTNTs and ultrafine PtRu NPs. This work reveals the critical application of a 1D interfacial functionalized architecture for advanced energy storage and conversion.
Construction of Two High‐Nuclear 3d‐4d Heterometallic Cluster Organic Frameworks by Introducing a Bifunctional Tripodal Alcohol as a Structure‐Directing Agent
Authors: Lin Li‐Dan , Ge Rui , Zhang Jing , Li Zhong , Yu Hao , Liu Jin‐Hua , Li Xin‐Xiong , Sun Yan‐Qiong , Zhao Dan , Zheng Shou‐Tian 
Published: March 2019

AbstractTwo unique heterometallic cluster organic frameworks, [Cd4MnIII4MnII6(Tri)4(CH3COO)14(μ4‐O)2(μ3‐O)2(H2O)2] Cd(H2O)2⋅9 H2O (1) and Cu[Cd5Cu6(Tri)4(CH3COO)9(H2O)4]2(CH3COO)3⋅24 H2O (2) (H3Tri=2‐(hydroxymethyl)‐2‐(pyridine‐4‐yl)‐1,3‐propanediol), have been successfully prepared by employing a bifunctional tripodal alcohol ligand as a structure‐directing agent. Crystal structure analyses reveal that 1 represents a rare example of frameworks constructed from Cd−Mn heterometallic chains, and 2 is the first heterometallic MOF based on highest‐nuclear Cd−Cu heterometallic cluster building blocks. Furthermore, the magnetic properties and gas adsorption abilities of 1 and 2 were systematically studied.
How much has urbanisation affected United Kingdom temperatures?
Authors: Goddard Ian L. M. , Tett Simon F. B. 
Published: March 2019

This study aims to estimate the affect of urbanisation on daily maximum and minimum temperatures in the United Kingdom. Urban fractions were calculated for 10 km × 10 km areas surrounding meteorological weather stations. Using robust regression a linear relationship between urban fraction and temperature difference between station measurements and ERA‐Interim reanalysis temperatures was estimated. For an urban fraction of 1.0, the daily minimum 2‐m temperature was estimated to increase by 1.90 ± 0.88 K while the daily maximum temperature was not significantly affected by urbanisation. This result was then applied to the whole United Kingdom with a maximum T
min urban heat island intensity (UHII) of about 1.7K in London and with many UK cities having T
min UHIIs above one degree.This paper finds through the method of observation minus reanalysis that urbanisation has significantly increased the daily minimum 2‐m temperature in the United Kingdom by up to 1.70 K.
Individual identification and correction of mistakes in statements of biochemical significance: An effective learning process for graduate medical students
Authors: Bobby Zachariah , Radhika M. R. , Srilatha K. , Nithin Kumar U. , Kavitha S. 
Published: March 2019

AbstractFocused self‐directed learning process needs to be promoted at present among graduate medical students in view of the information load and limited time available with them. In this study, comparison of the effect of identifying and correcting the mistakes in a given set of wrong statements with the effect of studying correct statements individually by graduate medical students on their understanding of the topic “Cancer Biology” was carried out. At the end of regular teaching module, students were asked to identify the mistakes in a set of seven incorrect statements and correct them individually without peer consultation. Another set of seven correct statements were also provided to them and were asked to study their significance. The effects on low, medium, and high achievers were evaluated by pre‐ and post‐tests with the same set of Multiple Choice Questions (MCQs). Mean post‐test marks were significantly higher among all the three groups compared to pretest marks for the wrong statements given. For the correct statements, the post‐test marks were significantly higher than the pretest marks only for the low and medium achievers. The gain from identifying the mistakes was higher than studying the correct statements for all the three groups of students. Individual correction of errors in statements is a superior active learning process in comparison to the study of correct statements. © 2019 International Union of Biochemistry and Molecular Biology, 47(4):476–480, 2019.
Counsellors in the National Health Service: A mixed‐method study of efficacy and satisfaction from the counsellor perspective
Authors: Ryan Gemma , Duncan Charlie , Moller Naomi P. 
Published: March 2019

AbstractBackgroundIt is difficult to know how many counsellors work in the UK's National Health Service (NHS). At a time when the British Government is pledging an expansion of the mental health workforce, it is important to understand both the opportunities and barriers for counsellors to work in the NHS.AimTo understand counsellors’ job roles, pay, perceptions of services, workplace stress and reasons for leaving the NHS.MethodAn online survey was advertised to members of the British Association for Counselling and Psychotherapy (BACP); just under 2,000 counsellors responded. The sample was majority female, white and had completed training. Mixed methods were utilised to analyse the data which incorporated use of thematic analysis.FindingsThe data suggest that, as a workforce, counsellors are prone to being “squeezed” out of the NHS workforce; that they are comparatively “underpaid,” are “pressurised” by high level of work demand and are consequently experiencing concerning levels of workplace stress; and that they perceive themselves to be, in multiple ways, “undervalued.” Despite this, members reported high adequacy of therapist qualifications and supervision quality within NHS services.ConclusionsCounsellors have expressed a desire to undertake more work in the NHS and are a potentially cost‐effective mental health workforce in comparison with other types of professionals. However, this study has evidenced significant structural, cultural and pay and promotion‐related barriers that are pushing counsellors out of the NHS. Of particular concern is what appears to be a broad undervaluing of counsellors as a professional group.
A homozygous genome‐edited Sept2‐EGFP fibroblast cell line
Authors: Banko Monika , Mucha‐Kruczynska Iwona , Weise Christoph , Heyd Florian , Ewers Helge 
Published: March 2019

AbstractSeptins are a conserved, essential family of GTPases that interact with actin, microtubules, and membranes and form scaffolds and diffusion barriers in cells. Several of the 13 known mammalian septins assemble into nonpolar, multimeric complexes that can further polymerize into filamentous structures. While some GFP‐coupled septins have been described, overexpression of GFP‐tagged septins often leads to artifacts in localization and function. To overcome this ubiquitous problem, we have here generated a genome‐edited rat fibroblast cell line expressing Septin 2 (Sept2) coupled to enhanced green fluorescent protein (EGFP) from both chromosomal loci. We characterize these cells by genomic polymerase chain reaction (PCR) for genomic integration, by western blot and reverse transcriptase‐PCR for expression, by immunofluorescence and immunoprecipitation for the colocalization of septins with one another and cellular structures and for complex formation of different septins. By live cell imaging, proliferation and migration assays we investigate proper function of septins in these cells. We find that EGFP is incorporated into both chromosomal loci and only EGFP‐coupled Sept2 is expressed in homozygous cells. We find that endogenous Sept2‐EGFP exhibits expression levels, localization and incorporation into cellular septin complexes similar to the wt in these cells. The expression level of other septins is not perturbed and cell division and cell migration proceed normally. We expect our cell line to be a useful tool for the cell biology of septins, especially for quantitative biology.
Azobenzene‐Based Photoswitches Facilitating Reversible Regulation of Kinesin and Myosin Motor Systems for Nanotechnological Applications
Authors: Amrutha Ammathnadu S. , Sunil Kumar K. R. , Tamaoki Nobuyuki 
Published: March 2019

AbstractThe past decade has witnessed several significant efforts made towards implementing the biomolecular functions of motor proteins for nanotechnological applications. However, employing motor protein systems in artificial environments demands for a precise and flexible spatiotemporal control mechanism. Light being an ideal external stimulus offers major advantages, allowing better spatial and temporal resolution compared to other diffusion‐based approaches. Robust photochromic properties of azobenzene make it a prime candidate that could be incorporated into biologically active molecules to realize two‐way regulation of motor protein function. In this Minireview, we summarize the design strategies of azobenzene‐based photoswitches for reversibly regulating kinesin‐ and myosin‐driven shuttle movements and briefly discuss photoisomerization‐induced modulation in motor protein activity.
Warming at the population level: Effects on age structure, density, and generation cycles
Authors: Laughton Alice M. , Knell Robert J. 
Published: March 2019

AbstractThe impact of climate change on strongly age‐structured populations is poorly understood, despite the central role of temperature in determining developmental rates in ectotherms. Here we examine the effect of warming and its interactions with resource availability on the population dynamics of the pyralid moth Plodia interpunctella, populations of which normally show generation cycles, a consequence of strong and asymmetric age‐related competition. Warming by 3°C above the standard culture temperature led to substantial changes in population density, age structure, and population dynamics. Adult populations were some 50% larger in warmed populations, probably because the reduced fecundity associated with warming leads to reduced larval competition, allowing more larvae to develop to adulthood. Warming also interacted with resource availability to alter population dynamics, with the generation cycles typical of this species breaking down in the 30° populations when standard laboratory diet was provided but not when a reduced nutrient poor diet was used. Warming by 6° led to either rapid extinction or the persistence of populations at low densities for the duration of the experiment. We conclude that even moderate warming can have considerable effects on population structure and dynamics, potentially leading to complete changes in dynamics in some cases. These results are particularly relevant given the large number of economically important species that exhibit generation cycling, in many cases arising from similar mechanisms to those operating in P. interpunctella.