bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three‐Dimensional Speckle Tracking Echocardiography Assessment of Right Ventricular Function in Chronic Coronary Syndrome Patients After Percutaneous Coronary Intervention
Authors: Hu WenShu , Zhou Chang , Sun Heng 
Published: October 2024

ABSTRACTObjectiveThis study aimed to assess alterations in right ventricular (RV) function following percutaneous coronary intervention (PCI) in patients with chronic coronary syndromes utilizing three‐dimensional speckle tracking echocardiography (3D‐STE).MethodsA prospective study was conducted involving 136 patients diagnosed with chronic coronary syndromes undergoing PCI, constituting the study group, alongside 110 age‐ and gender‐matched healthy volunteers serving as the control group. Echocardiographic evaluations, including both conventional and three‐dimensional assessments, were performed on all study participants at 1‐week, 6, and 12 months post‐PCI. Parameters such as tricuspid annular plane systolic excursion (TAPSE) were derived from conventional echocardiography, while tricuspid lateral annular systolic velocity (S') was measured via tissue Doppler imaging. 3D‐STE was utilized to quantify metrics including right ventricular fractional area change (RVFAC), right ventricular free wall longitudinal strain (RVFWLS), right ventricular global longitudinal strain (RVGLS), right ventricular stroke volume (RVSV), and right ventricular ejection fraction (RVEF).ResultsTAPSE, S', RVFAC, RVFWLS, RVGLS, RVSV, and RVEF exhibited significant increases from 1‐week to 6 months post‐PCI (p < 0.05). However, from 6 to 12 months post‐PCI, RVFAC, RVGLS, RVSV, and RVEF demonstrated no notable changes (p > 0.05). Meanwhile, TAPSE, S', and RVFWLS sustained significant elevations: TAPSE (19.63 ± 3.253% to 22.603 ± 2.885%, p < 0.001); S' (10.57 ± 2.643 to 12.61 ± 2.189 cm/s, p < 0.001); RVFWLS (18.64 ± 2.745% to 19.926 ± 3.291%, p = 0.002). At 12 months post‐PCI, S', RVFAC, RVGLS, RVSV, and RVEF remained lower than those of the healthy control group, but the differences were not statistically significant (p > 0.05). However, RVFWLS was significantly lower compared to the healthy control group (19.926 ± 3.291% vs. 22.10 ± 1.994%, p < 0.001).ConclusionFollowing PCI, right ventricular systolic function in patients with chronic coronary syndromes improves significantly over time. However, even at the 12‐month post‐PCI mark, RVFWLS remains lower than that of the control group. Notably, 3D‐STE emerges as a noninvasive method for quantifying right ventricular systolic function post‐PCI in chronic coronary syndrome patients.
Comparative assessment of phenotypic markers in patients with chronic inflammation: Differences on Bifidobacterium concerning liver status
Authors: Chero‐Sandoval Lourdes , Higuera‐Gómez Andrea , Martínez‐Urbistondo María , Castejón Raquel , Mellor‐Pita Susana , Moreno‐Torres Víctor , de Luis Daniel , Cuevas‐Sierra Amanda , Martínez J. Alfredo 
Published: October 2024

AbstractBackgroundThe relationship between systemic lupus erythematosus (SLE) and low‐grade metabolic inflammation (MI) with the microbiota is crucial for understanding the pathogenesis of these diseases and developing effective therapeutic interventions. In this context, it has been observed that the gut microbiota plays a key role in the immune regulation and inflammation contributing to the exacerbation through inflammatory mediators. This research aimed to describe similarities/differences in anthropometric, biochemical, inflammatory, and hepatic markers as well as to examine the putative role of gut microbiota concerning two inflammatory conditions: SLE and MI.MethodsData were obtained from a cohort comprising adults with SLE and MI. Faecal samples were determined by 16S technique. Statistical analyses compared anthropometric and clinical variables, and LEfSe and MetagenomeSeq were used for metagenomic data. An interaction analysis was fitted to investigate associations of microbiota with fatty liver index (FLI) depending on the inflammatory condition.ResultsParticipants with low‐grade MI showed worse values in anthropometry and biochemicals compared with patients with SLE. The liver profile of patients with MI was unhealthier, while no relevant differences were found in most of the inflammatory markers between groups. LEfSe analysis revealed an overrepresentation of Bifidobacteriaceae family in SLE group. An interactive association between gut Bifidobacterium abundance and type of disease was identified for FLI values, suggesting an effect modification of the gut microbiota concerning liver markers depending on the inflammatory condition.ConclusionThis study found phenotypical and microbial similarities and disparities between these two inflammatory conditions, evidenced in clinical and hepatic markers, and showed the interactive interplay between gut Bifidobacterium and liver health (measured by FLI) that occur in a different manner depending on the type of inflammatory disease. These results underscore the importance of personalized approaches and individual microbiota in the screening of different inflammatory situations, considering unique hepatic and microbiota profiles.
Neural encoding of melodic expectations in music across EEG frequency bands
Authors: Galeano‐Otálvaro Juan‐Daniel , Martorell Jordi , Meyer Lars , Titone Lorenzo 
Published: October 2024

AbstractThe human brain tracks regularities in the environment and extrapolates these to predict future events. Prior work on music cognition suggests that low‐frequency (1–8 Hz) brain activity encodes melodic predictions beyond the stimulus acoustics. Building on this work, we aimed to disentangle the frequency‐specific neural dynamics linked to melodic prediction uncertainty (modelled as entropy) and prediction error (modelled as surprisal) for temporal (note onset) and content (note pitch) information. By using multivariate temporal response function (TRF) models, we re‐analysed the electroencephalogram (EEG) from 20 subjects (10 musicians) who listened to Western tonal music. Our results show that melodic expectation metrics improve the EEG reconstruction accuracy in all frequency bands below the gamma range (< 30 Hz). Crucially, we found that entropy contributed more strongly to the reconstruction accuracy enhancement compared to surprisal in all frequency bands. Additionally, we found that the encoding of temporal, but not content, information metrics was not limited to low frequencies, rather it extended to higher frequencies (> 8 Hz). An analysis of the TRF weights revealed that the temporal predictability of a note (entropy of note onset) may be encoded in the delta‐ (1–4 Hz) and beta‐band (12–30 Hz) brain activity prior to the stimulus, suggesting that these frequency bands associate with temporal predictions. Strikingly, we also revealed that melodic expectations selectively enhanced EEG reconstruction accuracy in the beta band for musicians, and in the alpha band (8–12 Hz) for non‐musicians, suggesting that musical expertise influences the neural dynamics underlying predictive processing in music cognition.
Accumulated seizure burden predicts neurodevelopmental outcome at 36 months of age in patients with tuberous sclerosis complex
Authors: Ihnen S. Katie Z. , Alperin Samuel , Capal Jamie K. , Cohen Alexander L. , Peters Jurriaan M. , Bebin E. Martina , Northrup Hope A. , Sahin Mustafa , Krueger Darcy A. ,   the TACERN Study Group
Published: October 2024

AbstractObjectiveEpilepsy and intellectual disability are common in tuberous sclerosis complex (TSC). Although early life seizures and intellectual disability are known to be correlated in TSC, the differential effects of age at seizure onset and accumulated seizure burden on development remain unclear.MethodsDaily seizure diaries, serial neurodevelopmental testing, and brain magnetic resonance imaging were analyzed for 129 TSC patients followed from 0 to 36 months. We used machine learning to identify subgroups of patients based on neurodevelopmental test scores at 36 months of age and assessed the stability of those subgroups at 12 months. We tested the ability of candidate biomarkers to predict 36‐month neurodevelopmental subgroup using univariable and multivariable logistic regression. Candidate biomarkers included age at seizure onset, accumulated seizure burden, tuber volume, sex, and earlier neurodevelopmental test scores.ResultsPatients clustered into two neurodevelopmental subgroups at 36 months of age, higher and lower scoring. Subgroup was mostly (75%) the same at 12 months. Significant univariable effects on subgroup were seen only for accumulated seizure burden (largest effect), earlier test scores, and tuber volume. Neither age at seizure onset nor sex significantly distinguished 36‐month subgroups, although for girls but not boys there was a significant effect of age at seizure onset. In the multivariable model, accumulated seizure burden and earlier test scores together predicted 36‐month neurodevelopmental group with 82% accuracy and an area under the curve of .86.SignificanceThese results untangle the contributions of age at seizure onset and accumulated seizure burden to neurodevelopmental outcomes in young children with TSC. Accumulated seizure burden, rather than the age at seizure onset, most accurately predicts neurodevelopmental outcome at 36 months of age. These results emphasize the need to manage seizures aggressively during the first 3 years of life for patients with TSC, not only to promote seizure control but to optimize cognitive function.
TOPS: A Framework for Trusted Opinion Analysis of Product Reviews Using Hybrid Deep Learning Based D2CL Filter
Authors: Balaji T. K. , Bablani Annushree , Sreeja S. R. , Misra Hemant 
Published: October 2024

ABSTRACTThe rapid growth of online product reviews has made it increasingly challenging for consumers to make informed purchase decisions. However, the abundance of reviews, including fake or augmented and sarcastic reviews, poses a challenge for consumers. To address this challenge, this paper introduces the TOPS (Trusted Opinion analysis of Product reviewS) framework, a novel approach that leverages a hybrid deep learning‐based D2CL (Dual Deep leaning based cleaning) filter to enhance the reliability of online reviews. The proposed methodology employs the D2CL filter to identify and eliminate fake and sarcastic reviews, ensuring that the consolidated sentiment analysis provides users with trustworthy opinions. The framework is equipped with the R‐mGRU, a hybrid deep learning model specifically designed to tackle the nuances of product reviews. This model has demonstrated impressive accuracy rates, achieving 89%, 91%, and 94% for fake, sarcasm, and sentiment analysis tasks, respectively. The TOPS framework makes a significant contribution to improving the overall quality and authenticity of product reviews, empowering consumers with more reliable information for informed decision‐making in online shopping scenarios.
The Crack Growth Resistance of Polymeric Cellular Materials Studied With a Quasi‐Brittle Approach
Authors: Wetta Maxime , Kopp Jean‐Benoit , Fournier Vincent , Le Barbenchon Louise , Viot Philippe , Morel Stéphane 
Published: October 2024

ABSTRACTThis research delves into the fracture analysis of cellular thermosetting polymers using Mode I fracture tests with a compact tension geometry subjected to both monotonic and cyclic loadings. The equivalent linear elastic fracture mechanics concept effectively described crack initiation and propagation. Numerical simulations estimated the equivalent linear elastic crack length aligning with experimental measurements. Resistance curves revealed a transient regime followed by a self‐similar regime with relatively constant fracture energy, typical of quasi‐brittle materials. Finally, the fracture energy evolution correlated with macroscopic density evolution exhibiting a linear relationship relaying the influence of microstructure to a second order.
Synergistic Effects of Irrigation and Nitrogen Fertilisation on Maize Photosynthetic Performance and Yield of Rainfed Systems in Drought‐Prone Environments
Authors: Huang Ya , Gao Fei , Khan Rayyan , Ali Shahid , Zhou Xun Bo 
Published: October 2024

ABSTRACTMaize, a cereal crop of global significance, encounters cultivation challenges in the subtropical regions of Guangxi, mainly due to variable rainfall and low soil fertility, exacerbating the effects of drought. This study evaluated the effects of irrigation and nitrogen fertilisation on overcoming these challenges and improving maize growth and yield. Between 2020 and 2021, a split‐plot experiment was conducted. The main plots were assigned to two irrigation treatments: irrigated and rainfed. Within each main plot, subplots were treated with different nitrogen levels (0, 150, 200, 250 and 300 kg ha−1). The results showed that nitrogen levels and water regime significantly impacted several key factors, including the net photosynthetic rate (Pn), stomatal conductance (Gs), transpiration rate (Tr), intercellular carbon dioxide concentration (Ci), photosynthetically active radiation (PAR), carbon‐metabolising enzymes and total carbon (TC) content accumulation. Under drought‐like rainfed conditions, the application of nitrogen, RN300 (rainfed application nitrogen 300 kg ha−1), IN250 (irrigated application nitrogen 250 kg ha−1) significantly enhanced the Pn (10.0%), Tr (3.17%), Ci (3.41%) and Gs (2.6%). Additionally, PAR was significantly influenced by the water regime and nitrogen levels. Under IN250, the capture ratio (Ca) increased (2.36%), while the penetration ratio (Pe) and reflectance ratio (Re) decreased by 13.12% and 46.36%, respectively, compared to RN300. The levels of carbon metabolism enzymes (sucrose phosphate synthase and phosphoenolpyruvate carboxylase) and the TC content were higher under RN300 compared to IN250; however, these differences were not statistically significant. Path analysis revealed that thousand kernel weight had the most significant impact on yield under both water regimes. The effect was stronger under irrigated conditions, with a path coefficient of 0.647, compared to 0.459 under rainfed conditions. Correlation analysis indicated that plant height (0.938), stem diameter (0.906), ear diameter (0.928) and ear length (0.803) were positively correlated with nitrogen levels. In conclusion, maize under IN250 exhibited superior photosynthetic performance and carbon accumulation. This suggests that balanced irrigation and nitrogen management can effectively mitigate the adverse impacts of drought on maize, optimising growth and yield sustainably.
Order evolution from a high‐entropy matrix: Understanding and predicting paths to low‐temperature equilibrium
Authors: Almishal Saeed S. I. , Miao Leixin , Tan Yueze , Kotsonis George N. , Sivak Jacob T. , Alem Nasim , Chen Long‐Qing , Crespi Vincent H. , Dabo Ismaila , Rost Christina M. , Sinnott Susan B. , Maria Jon‐Paul 
Published: October 2024

AbstractInterest in high‐entropy inorganic compounds originates from their ability to stabilize cations and anions in local environments that rarely occur at standard temperature and pressure. This leads to new crystalline phases in many‐cation formulations with structures and properties that depart from conventional trends. The highest‐entropy homogeneous and random solid solution is a parent structure from which a continuum of lower‐entropy offspring can originate by adopting chemical and/or structural order. This report demonstrates how synthesis conditions, thermal history, and elastic and chemical boundary conditions conspire to regulate this process in Mg0.2Co0.2Ni0.2Cu0.2Zn0.2O, during which coherent CuO nanotweeds and spinel nanocuboids evolve. We do so by combining structured synthesis routes, atomic‐resolution microscopy and spectroscopy, density functional theory, and a phase field modeling framework that accurately predicts the emergent structure and local chemistry. This establishes a framework to appreciate, understand, and predict the macrostate spectrum available to a high‐entropy system that is critical to rationalizing property engineering opportunities.
The Pedagogical Power of Paper
Authors: Rodgers Suzanne 
Published: October 2024

AbstractIn this research, I explore the potential of a material‐led, embodied pedagogical approach to cultivate diverse modes of thinking, knowing and becoming within a pre‐GCSE curriculum. Drawing from my experiences as both an artist and educator, I acknowledge the transformative power inherent in recognising the agency of all forms of matter, whether human or non‐human. Through the implementation of a project titled ‘To Play,’ which utilises paper as a primary pedagogical tool, I engaged Year 9 Art and Design students. Qualitative data collected over a six‐week period underpins the analysis, with a particular emphasis on understanding students' experiences with material‐led processes. The findings highlight the potential of material‐led pedagogies to empower students and challenge anthropocentric perspectives, offering valuable insights for enhancing pre‐GCSE art education and harnessing the educational potential of materials. This study contributes to the ongoing discourse in art education by emphasising the importance of embodied, experiential learning approaches that prioritise creativity, exploration and critical engagement with the world around us.
Proteome of Clothianidin Exposed Honey Bees Reveals a Possible Mechanism Behind Impairment of Sucrose Responsiveness
Authors: Tsvetkov Nadejda , Moon Kyung‐Mee , Foster Leonard J. 
Published: October 2024

ABSTRACTNeonicotinoids (NNIs) are the most commonly used insecticides in the world and clothianidin, a type of NNI, is commonly found in honey bee collected pollen. Clothianidin has several negative effects on honey bee health and behaviour, but whether and how it might impact learning and memory remains unclear. Therefore, we exposed honey bee workers to a field‐realistic oral dose of clothianidin for 7 days to assess their sugar responsiveness, and olfactory learning and memory using the proboscis extension response paradigm. Sugar responsiveness impacts important colony‐level traits, such as onset of foraging, that help maintain colony homeostasis as well as impacts learning and memory. We then measured how clothianidin alters protein expression in the brain in an effort to understand the mechanism(s) of clothianidin's effects. Clothianidin‐exposed bees had impaired sugar responsiveness, but no effect was seen on learning and memory. We identified 5069 protein groups and showed that the exposed bees had fewer detectable proteins. The exposed bees also had fewer mitochondrial respiration proteins, as well as reduced levels of nicotinic acetylcholine receptor α7 (nAChRα7) subunit (one of the targets of clothianidin) and reduced levels of acetylcholinesterase and acetylcholinesterase‐2 levels. In the exposed bees, the levels of nAChRα7 subunit positively correlated with sugar responsiveness, providing evidence for a possible mechanical explanation.
Registered Nurses' Familiarity With Delegation Standards and Confidence Delegating to Unlicenced Care and Support Workers: A Cross‐Sectional Study
Authors: Wilson Nathan J. , Pracilio Amy , Morphet Julia , Buckley Thomas , Trollor Julian N. , Cashin Andrew 
Published: October 2024

ABSTRACTAimTo survey registered nurses' familiarity with delegation standards and confidence to delegate to unlicenced workers within their practice.DesignCross‐sectional exploratory survey design.MethodsThe survey focused on Australian registered nurses (n = 420). Initial descriptive analysis was undertaken. Additionally, inferential analysis was undertaken between two independent variables focused on familiarity of delegation policy, and confidence to delegate, and several demographic and workplace variables. Stepwise linear regression was undertaken to determine predictors of the two delegation variables. The cross‐sectional study was undertaken according to the STROBE reporting checklist.ResultsThe majority of respondents were somewhat familiar, or not familiar at all with delegation standards. This pattern was followed for results relevant to confidence delegating to unlicenced workers. Nurses working in adult acute, intensive care and emergency department reported the lowest levels of familiarity with delegation. Additionally, intensive care nurses were significantly less likely to feel very confident delegating to unlicenced support workers. Stepwise regression revealed identifying as male, and working in the public sector were less likely to be confident delegating. Nurses working in the acute setting and public sector were less familiar with delegation standards.ConclusionThe findings of this study highlight the nuanced nature of delegation to unlicenced workers in Australian nursing settings, with nurses from certain contexts being far less likely to be familiar with or confident undertaking the practice.Implications for Clinical PracticeThe findings of this study have significant implications to increase understanding of nurses diverse contexts of practice and how delegation standards might not be implemented in practice in a confident manner.
Clinical trial protocol for continuous glucose monitoring in critical care at Hospital Clinic of Barcelona (CGM‐UCI23)
Authors: Pañero‐Moreno Marc , Guix‐Comellas Eva Maria , Villamor‐Ordozgoiti Alberto 
Published: October 2024

AbstractBackgroundHyperglycaemia is common in intensive care units (ICUs), with a prevalence of up to 86.2%, increasing mortality. Technology has evolved towards continuous glucose monitoring (CGM), and its use in ICUs began especially during the coronavirus pandemic (COVID‐19). Various studies have evaluated the reliability of CGM, indicating that it is safe for use in critically ill patients.AimsThe aim of this study was to compare the use of CGM with point‐of‐care glucose (POC‐G) testing in ICU. Specific objectives include evaluating the glycaemic control, the frequency of POC‐G measurements, the incidence of hyperglycaemia, hypoglycaemia and morbidity and mortality at 90 days.Study DesignAn experimental, controlled and randomized clinical trial with a single‐blind design will be conducted at Hospital Clinic of Barcelona (HCB). A sample size of 376 participants will be recruited and randomly assigned to two groups: an experimental group, where glycaemic management will be based on CGM; and a control group, where glucose will be managed through POC‐G testing, with a blinded CGM.ResultsThe primary variable considered will be time in range (TIR), with secondary outcomes including, time above range (TAR), time below range (TBR), number of POC‐G measurements, incidence of hyperglycaemia and hypoglycaemia, and mortality. Hypothesis testing will use the Kolmogorov–Smirnov test to assess data normality, with appropriate statistical tests applied, considering a p‐value <.05.Relevance to Clinical PracticeThe results obtained will help us understand the impact of CGM on critically ill patients. CGM could potentially reduce the workload of nurses and improve the efficiency of decision‐making by the ICU team, enabling early identification and treatment of glucose complications, thereby enhancing safety. Patient safety, a reduction in patient fingerstick and a decreased care burden are the criteria that add value to this research.