bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative and correlative study of the Voice-Related Quality of Life (V-RQOL) and the Voice Activity and Participation Profile (VAPP) for voice-related quality of life among teachers with and without voice disorders
Authors: Yu Lingyu , Lu Dan , Yang Hui , Zou Jian , Wang Haiyang , Zheng Meijun , Hu Juanjuan 
Published: February 2019

Abstract
The aim of this study was to investigate the difference and correlation between the Voice-Related Quality of Life (V-RQOL) and the Voice Activity and Participation Profile (VAPP) among teachers.
The participants were 672 teachers (218 males and 454 females, male-to-female ratio = 0.48:1) whose vocal cords were examined using a Strobolaryngoscope. Questionnaire results were obtained for both the V-RQOL and the VAPP.
Of the 672 participants, 322 teachers had voice disorders while 350 teachers did not. The most common voice complaint was hoarseness (n = 250), and the most common throat complaint was foreign body sensation (n = 129) in teachers with voice disorders. Chronic laryngitis (n = 162, 50.3%), vocal cord polyps (n = 92, 28.6%), and vocal cord nodules (n = 43.13.4%) were the most frequent diagnoses in teachers with voice disorders. Significant differences were seen on the V-RQOL and the VAPP scores between teachers with and without voice disorders, and between female and male teachers. Differences were also observed among teachers from different grades, and among different types of voice-related diseases. Moderate-to-strong correlations were observed between the VAPP total score and those for all the subscales of the VAPP and between the VAPP total score and the V-RQOL score (P < .001).
Teachers with voice disorders have a significantly poorer voice-related quality of life than those without voice disorders, as do female teachers compared with male teachers. Different groups of voice disorders have different effects on teachers’ voice-related quality of life, and primary school teachers suffer from a poorer voice-related quality of life than do high school teachers. A moderate-to-strong correlation was found between the results of the V-RQOL and the VAPP scores.
Electrical stimulation for limb spasticity in children with traumatic brain injury
Authors: Wang He , Song Guang-fu , Nie Jing , Xu Xiao-hao , Zhang Ying , Liu Jin-rui 
Published: February 2019

Abstract

Background:
Previous clinical studies have reported that electrical stimulation (ES) can be utilized to treat children with limbs spasticity (LS) after traumatic brain injury (TBI). Currently, no systematic review has addressed the effect of ES in children with LS following TBI. Thus, this systematic review will assess the effect and safety of ES for the children with LS after TBI.

Methods:
We will conduct the present systematic review of randomized controlled trials that will be retrieved from searches of PubMed, PsycINFO, WOS, Scopus, OpenGrey, Google Scholar, Cochrane Central Register of Controlled Trials, Embase, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database from the inception to the date of the literature searched. In addition, the clinical register websites, and reference lists of relevant studies will also be searched. Two independent reviewers will evaluate the eligibility criteria for all papers, extract the data and determine the methodology quality by using Cochrane risk of bias tool.

Results:
The results of this systematic review will pool the latest available data, and are expected to provide the summary of present evidence of ES for children with LS following TBI.

Timeline:
This systematic review will start on January 10, 2019 and expected to complete by June 1, 2019.

Ethics and dissemination:
No research ethic approval is needed in this study, because the data of this systematic review will not base on the individual data level. The results will be disseminated to publish at peer-reviewed journals or will present at relevant conferences.

PROSPERO registration number:
CRD42019120037
A randomized trial of trigger point dry needling versus sham needling for chronic tension-type headache
Authors: Gildir Sila , Tüzün Emine Handan , Eroğlu Goncagül , Eker Levent 
Published: February 2019

Abstract

Background:
In this randomized, double-blind, parallel-group trial, we aimed to explore the effectiveness of trigger point dry needling in patients with chronic tension-type headache in reducing headache frequency, intensity and duration, and improvement of health-related quality of life.

Methods:
The 168 patients in 2 neurology clinics with chronic tension-type headache. The participants were randomly assigned to one of two treatment groups for dry needling or sham dry needling, delivered in 3 sessions a week for 2 weeks. The 160 patients fulfilled the study requirements. The dry needling was applied in active trigger points located in the musculature of the head and the neck. The patients received dry needling using sterile stainless-steel acupuncture needles of 0.25 × 40 mm and 0.25 × 25 mm dimensions. The sham dry needling procedure was applied into the adipose tissue located at any area where an active trigger point was absent. The primary outcome measurement was the headache intensity. Secondary outcomes were frequency and duration of headache, and quality of life, assessed by the Short Form-36. All outcomes were measured at baseline, at the end of 2-week, and 1-month follow-up period.

Results:
In the dry needling group, intensity, frequency and duration of headache, and the scores of Short Form-36 subscales were significantly improved after treatment (P < .05). In the dry needling group, all the effect sizes for headache variables were large.

Conclusions:
The results of this clinical trial suggest that trigger point dry needling in patients with chronic tension-type headache is effective and safe in reducing headache intensity, frequency and duration, and increasing health-related quality of life.

Trial registration:
Clinical Trials NCT03500861.
Herbal medicines for metabolic diseases with blood stasis
Authors: Ko Mi Mi , Jang Soobin , Jung Jeeyoun 
Published: February 2019

Abstract

Background:
Herbal medicines have the potential to be alternative treatments for metabolic diseases. This systematic review will assess the efficacy of herbal medicines in treating metabolic diseases with blood stasis.

Methods and analysis:
We will search MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, 2 Korean medical databases (OASIS, NDSL), a Chinese database (China National Knowledge Infrastructure, CNKI), and a Japanese database (J-STAGE) for relevant literature. We will include all randomized controlled trials (RCTs) or quasi-RCTs evaluating the effectiveness of herbal medicine. Participants of both sexes and of any age with clinically diagnosed metabolic disease with blood stasis will be included. Primary outcomes will include Blood-stasis syndrome score, TC, TG, HDL-C and LDL-C. Secondary outcomes will Blood pressure, FBS. ECG, prevalence rate of heart disease, and response rate. The risk of bias will be assessed using the Cochrane tool for assessing risk of bias.

Discussion:
The findings of this study will provide a summary of the current state of evidence regarding the effectiveness of types of herbal medicine in managing metabolic disease with blood stasis. In addition, this review will be expected to provide a base for clinical trials to confirm the efficacy of herbal medicine for treatments of metabolic disease with blood stasis.

Trial registration number:
PROSPERO 2018 CRD42018090179.
Effect of 12-month nasal continuous positive airway pressure therapy for obstructive sleep apnea on progression of chronic kidney disease
Authors: Li Xiaoming , Liu Chengcheng , Zhang Hao , Zhang Jie , Zhao Miaoqing , Sun Dianshui , Xia Ming , Han Min 
Published: February 2019

Abstract

Background:
Obstructive sleep apnea (OSA) is common among patients with chronic kidney disease (CKD). CKD may increase the risk of OSA, and OSA may increase the risk of renal injury. Nasal continuous positive airway pressure (nCPAP) is the standard treatment for OSA. However, the effect of nCPAP on the progression of CKD is unclear.

Methods:
A total of 395 patients with stage 3/4 CKD were initially examined, and 269 patients (148 non-OSA cases; 79 mild OSA cases; 42 moderate/severe OSA cases) were analyzed after implementation of the exclusion criteria. The severity of OSA was determined by polysomnography (PSG). Fifty-two OSA patients (32 mild OSA cases; 20 moderate/severe OSA cases) received nCPAP treatment for 12 months. Variables associated with OSA severity and estimated glomerular filtration rate (eGFR) were evaluated before and after the 12-month nCPAP treatment.

Results:
Among all 269 CKD patients, body mass index (BMI), and eGFR had significant associations with OSA severity. Age, BMI, apnea–hypopnea index (AHI), mean SaO2%, and SaO2 <90% monitoring time had independent associations with lower eGFR. The 12-month nCPAP treatment significantly reduced the rate of eGFR decline. Univariate and multivariate analysis indicated that age, BMI, AHI, mean SaO2%, and SaO2 <90% monitoring time were independently associated with reduced eGFR. Furthermore, nCPAP treatment significantly improved eGFR, AHI, mean SaO2, and SaO2 <90% monitoring time in patients with mild OSA, and improved systolic/diastolic blood pressure, urinary protein level, eGFR, AHI, mean SaO2, and SaO2 <90% monitoring time for patients with moderate/severe OSA.

Conclusion:
This study of patients with CKD and OSA indicated that nCPAP therapy significantly ameliorated CKD progression, especially in those with moderate/severe OSA.
Prevalence of human papillomavirus type-18 in head and neck cancer among the Chinese population
Authors: Yang Funa , Yin Yulin , Li Peng , Zhang Xiaojun , Chen Defeng , Liu Yang , Wang Jian , Guo Lanwei 
Published: February 2019

Abstract

Background:
China has a high burden of head and neck cancer globally and oncogenic human papillomavirus (HPV) has been hypothesized as a risk factor for head and neck cancer, but research was absent for establishing HPV prevalence in China. We aimed to conduct a meta-analysis to estimate the high-risk HPV-18 prevalence of head and neck cancer in the Chinese population.

Methods:
This meta-analysis was reported following the guideline of PRISMA. The reports on HPV and head and neck cancer in a Chinese population published between Jan 1, 2006 and May 31, 2018 were retrieved via CNKI/WANFANG/MEDLINE/EMBASE/COCHRANE databases. A random-effect model was used to calculate pooled prevalence and corresponding 95% confidence intervals.

Results:
A total of 1881 head and neck cancer cases from 19 studies were included in this meta-analysis. Overall, the pooled HPV-18 prevalence among head and neck cancer cases was 6.0% (4.1%–7.9%) in China, 31.2% (13.0%–49.4%) in laryngeal cancer, 7.2% (3.9%–10.5%) in oral cancer and 0.6% (0.0%–1.3%) in oropharyngeal cancer, 18.7% (6.2%–31.2%) in fresh or frozen biopsies and 4.3% (2.5%–6.1%) in paraffin-embedded fixed biopsies, 29.5% (15.6%–43.3%) by E6/E7 region and 3.9% (0.5%–7.4%) by L1 region of HPV gene. The highest HPV-18 prevalence was found in Central China.

Conclusions:
High prevalence of HPV-18 was found in the samples of Chinese head and neck cancers. Prophylactic HPV-vaccination may reduce the burden of HPV-related head and neck cancer in China.
A case report of placental mesenchymal dysplasia
Authors: Doroftei Bogdan , Neculai-Valeanu Sabina , Simionescu Gabriela , Grab Delia , Plopa Natalia , Anton Emil , Maftei Radu 
Published: February 2019

Abstract

Rationale:
We report a rare case of a pregnant woman with placental mesenchymal dysplasia (PMD) and intrauterine growth restriction (IUGR) with a genetically normal fetus.

Patient concerns:
A 42-year-old woman Gravida I, Para I with pre-existent uncontrolled hypertension and uterine polyfibromatosis present at 30 weeks of gestation for diminished fetal activity during the last 2 days.

Diagnosis:
Placental mesenchymal dysplasia associated with intrauterine growth restriction, hypertension, and uterine polyfibromatosis.

Intervention:
A live male infant was delivered by emergency caesarean section.

Outcomes:
The infant, weighing 700 g, died 4 days after birth due to a massive intracerebral hemorrhage.

Lessons:
A careful examination should be done at every ultrasound in case of a fetus with IUGR to exclude some rare cases of placental pathologies. PMD can be a rare cause of IUGR with a genetically normal fetus.
Spindle cell hemangioma of the spleen
Authors: Gao Bing-Qiang , Zhou Dong-Kai , Qian Xiao-Hui , Zhang Wang , Ying Li-Xiong , Wang Wei-Lin 
Published: February 2019

Abstract

Rationale:
Spindle cell hemangioma (SCH) is considered a benign vascular lesion. It typically develops as a solitary nodule or multiple masses located in the dermal or subcutaneous layers of the distal extremities. To the best of our knowledge, there are no prior reports of SCH in the spleen.

Patient concerns:
A 41-year-old male was admitted to our hospital with recurrent headaches, nausea, and vomiting persisting for 5 days. Ultrasound, computed tomography, and magnetic resonance imaging revealed multiple space-occupying lesions in the spleen, and the biggest lesion was 4.8 cm × 5.4 cm in size.

Interventions:
The patient underwent laparoscopic splenectomy.

Diagnosis:
A diagnosis of spindle cell hemangioma of the spleen was made based on the histopathology.

Outcomes:
No evidence of local recurrence or distant metastases was observed over 4-year follow-up.

Lessons:
Splenic SCH may exhibit relatively high proliferative activity and be comorbid with epithelioid hemangioendothelioma or angiosarcoma, raising the possibility of malignant potential. However, the patient remained alive and disease-free 4 years after the operation. The nature of SCH in deep soft tissues requires further study.
Multifocal muscle candidiasis of the legs in a patient with acute myeloid leukemia
Authors: Yi Ping , Yang Xiang , Yang MeiFang , Zhang Yan , Li Lanjuan 
Published: February 2019

Abstract

Rationale:
Opportunistic infections frequently develop in immunocompromised patients, such as those with hematological malignancies, causing significant mortality. Early diagnosis of invasive fungal infections is often important and difficult due to the difficult nature of confirming infection using cytologic and histologic findings. However, we report the first case of candidal infection leading to muscle abscesses in the legs of a patient with leukemia.

Patient concerns:
A 60-year-old man with acute myeloid leukemia (AML) presented with multifocal muscle abscesses of the legs.

Diagnoses:
Multifocal muscle candidiasis of the legs was confirmed by fine-needle aspiration biopsy of 2 of the calf lesions.

Interventions:
After treatment with amphotericin B and flucytosine for 1 month, the patient was administered intravenous caspofungin for 3 months.

Outcome:
A CT scan of the abdomen and an MRI of the lower calves showed significant improvement.

Lessons:
This case highlights that fungal infection should be considered when patients present with multiple abscesses, emphasizing the value of early biopsy to confirm diagnosis and facilitate precision treatment.
A case report of 131I therapy for Graves’ disease patient with hemiagenesis
Authors: Liu Xuehui , Zhang Jianping , Meng Zhaowei , Yu Hongxu , Gao Zhimin , Li Hongjun , Liu Na 
Published: February 2019

Abstract

Rationale:
Thyroid hemiagenesis is a rare congenital dysplasia, whereas a variety of pathological changes may occur in residual thyroid lobe. The most frequently described pathology in residual thyroid lobe is Graves’ hyperthyroidism. Although 131I therapy has been generally recommended as the preferred treatment for Graves’ disease (GD), subjects relating to hemiagenesis are very limited, especially in China.

Patient concerns:
A 43-year-old female patient presented to our hospital on November 2014, with a 1-year history of palpitation, fatigue, and hand tremor. Her situation was getting worse within 2 months.

Diagnosis:
The thyroid function tests were suggestive of thyrotoxicosis. The technetium thyroid scintigraphy only showed an enlarged right lobe with increased tracer uptake. Then, the agenesis of left lobe and isthmus was confirmed by ultrasound and magnetic resonance imaging (MRI). Thus, a diagnosis of GD with hemiageneis of the left lobe and isthmus of thyroid was made.

Interventions:
Thiamazole was discontinued because of drug-induced hepatic injury. According to our procedures, the patient was treated by 131I.

Outcomes:
Hypothyroidism was observed 3 months after 131I therapy. After replacement therapy with L-thyroxine (LT4), the state of euthyroid maintained.

Lessons:
Once hypothyroidism occurs, regular application of LT4 and review of thyroid function is very important. Thus, patients’ compliance needs to be strengthened. Besides, we could not convince the family members of our patient to undergo ultrasonographic examination. The genetic factor of the agenesis could not be proved in this case.
Protocol for the development and validation of a driving simulator for evaluating the influence of drugs on driving performance
Authors: Iwata Mari , Iwamoto Kunihiro , Omura Tomohiro , Ando Masahiko , Ozaki Norio 
Published: February 2019

AbstractIntroduction:Although automobile driving is often necessary in daily life, most package inserts for psychotropic drugs in Japan prohibit patients from driving under the influence of medication. This may be partially because no system to evaluate the influence of drugs on driving performance has been established. Standardized evaluation methods have been established in the Netherlands and the United States, but these cannot be implemented in Japan because of differences in road situations, traffic laws, and ethnicities. Therefore, to establish a method to evaluate the influence of drugs on driving performance in Japan, we planned a validation study using alcohol and a driving simulator (DS) and set a clinically meaningful threshold involving the standard deviation of lateral position (SDLP), which is a criterion standard evaluation item.Methods:This study was designed as a double-blind, placebo-controlled, randomized, 4-way, fourth-order crossover trial (Williams design). Twenty-four healthy Japanese men aged 21 to 64 years will be recruited through advertisements. The participants will be required to drive daily for over 3 years and to carry the active-type aldehyde dehydrogenase (ALDH) gene polymorphism (ALDH 2∗1/∗1). Participants will be randomly assigned to 4 groups based on blood alcohol concentration (BAC): 0% (placebo), 0.025%, 0.05%, and 0.09%. The amount of alcohol intake will be calculated based on Widmark formula using a beverage that is a mixture of 40% vodka and orange juice. After a practice period, each examination period will be set with 6-day intervals. The primary outcome is SDLP in a 60-minute road-tracking test using the DS. The secondary outcomes are other evaluation items in the DS tasks and DS sickness and sleepiness according to questionnaire responses. The estimated difference in SDLP between BAC levels of 0.05% and 0% will be calculated using a linear model.Ethics and dissemination:Ethics approval was obtained from the Ethics Committee at Hakata Clinic and the Nagoya University Medical School Hospital Bioethics Review Committee. The trial results will be disseminated through peer-reviewed publications and international conferences.Trial registration:This study was registered at ClinicalTrials.gov NCT 03572985 on June 28, 2018.
Correlation between clinical and pathological features of oral lichen planus
Authors: Boñar-Alvarez Paula , Pérez Sayáns Mario , Garcia-Garcia Abel , Chamorro-Petronacci Cintia , Gándara-Vila Pilar , Luces-González Romina , Otero Rey Eva , Blanco-Carrión Andres , Suárez-Peñaranda JM 
Published: February 2019

Abstract
Oral lichen planus (OLP) is a common, chronic, inflammatory disease of autoimmune origin. The aim of this study is to determine the correlation of the histopathological features with clinical aspects and variants of OLP.
We have retrospectively studied a group of 59 adult patients with confirmed clinical and histopathological diagnosis of OLP from the Oral Pathology Unit of the University of Santiago de Compostela (Spain). Clinical parameters: age, gender, location of the lesions, clinical type, toxic habits, and concomitant treatments were evaluated. Histopathologically, the epithelial response (hyperplasia vs atrophy), presence of ulceration, degree of interface lesion and distribution, intensity, and composition of the inflammatory infiltrate were analyzed.
Patients treated with several systemic drugs had more atrophic/erosive forms of OLP (P = .019). Plasma cells were found more commonly in cases showing deep inflammatory involvement of the connective subepithelial tissue than in those where inflammation was only superficially located (P <.001). Their presence was also associated with epithelial erosion-ulceration (P <.01).
In conclusion, patients treated with several drugs had more atrophic/erosive forms of OLP and frequently associated with a deep specific inflammatory pattern based on plasma cells. Our results could suggest that drug intake by some patients might confer a supplementary aggravating character to the disease, alone or in conjunction with other non-identified factors. More studies should be carried out to confirm this trend and to assess whether this characteristic, can actually influence the evolution of the lesions.
Diffuse alveolar hemorrhage following sugammadex and remifentanil administration
Authors: Choi Won Kyu , Lee Jae Myeong , Kim Jong Bun , Im Kyong Shil , Park Bong Hee , Yoo Su Bin , Park Cha Yun 
Published: February 2019

Abstract

Rationale:
Diffuse alveolar hemorrhage (DAH) is a rare life-threatening condition that accompanies general anesthesia. Negative-pressure pulmonary edema (NPPE) is a rare cause of DAH.

Patient concerns:
A 25-year-old male patient developed hemoptysis following remifentanil administration by bolus injection with sugammadex at the emergence from general anesthesia.

Diagnosis:
Chest x-ray and computed tomography showed DAH.

Interventions:
Conservative care was provided with 4L of oxygen via nasal prong, 20 mg of Lasix and 2500 mg of tranexamic acid.

Outcomes:
The patient was discharged uneventfully.

Lessons:
Muscle rigidity by remifentanil and the dissociated reversal of neuromuscular blockade by sugammadex was suspected as the cause of NPPE-related DAH. Therefore, the possibility NPPE-related DAH should be considered when using a bolus of remifentanil and sugammadex during emergence from general anesthesia.