bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a Redesigned Personal Protective Equipment Gown
Authors: Drews Frank A , Mulvey Diane , Stratford Kristina , Samore Matthew H , Mayer Jeanmarie 
Published: June 2019

Abstract

Background
In healthcare, the goal of personal protective equipment (PPE) is to protect healthcare personnel (HCP) and patients from body fluids and infectious organisms via contact, droplet, or airborne transmission. The critical importance of using PPE properly is highlighted by 2 potentially fatal viral infections, severe acute respiratory syndrome–associated coronavirus and Ebola virus, where HCP became infected while caring for patients due to errors in the use of PPE. However, PPE in dealing with less dangerous, but highly infectious organisms is important as well. This work proposes a framework to test and evaluate PPE with a focus on gown design.

Methods
An observational study identified issues with potential for contamination related to gown use. After redesigning the existing gown, a high-fidelity patient simulator study with 40 HCP as participants evaluated the gown redesign using 2 commonly performed tasks. Variables of interest were nonadherence to procedural standards, use problems with the gown during task performance, and usability and cognitive task load ratings of the standard and redesigned gowns.

Results
While no differences were found in terms of nonadherence and use problems between the current and the redesigned gown, differences in usability and task load ratings suggested that the redesigned gown is perceived more favorably by HCP.

Conclusions
This work proposes a framework to guide the evaluation of PPE. The results suggest that the current design of the PPE gown can be improved in usability and user satisfaction. Although our data did not find an increase in adherence to protocol when using the redesigned gown, it is likely that higher usability and lower task load could result in higher adherence over longer periods of use.
Transdiaphragmatic Mucormycosis
Authors: Koehler Philipp , Reimer Robert , Wahba Roger , Schömig-Markiefka Birgid , Cornely Oliver A 
Published: June 2019

Abstract
Mucormycosis is a life-threatening infection. This is the first report of transdiaphragmatic mucormycosis in a series of 3 patients. We observed this phenomenon in 11% of patients. Clinicians should be aware of this possibly underreported entity, and as a consequence we envision more comprehensive imaging studies in patients with mucormycosis.
Targeting protein tyrosine phosphatase PTP-PEST (PTPN12) for therapeutic intervention in acute myocardial infarction
Authors: Yang Chiu-Fen , Chen Yi-Yun , Singh Jai Prakash , Hsu Shu-Fang , Liu Yu-Wen , Yang Chun-Yi , Chang Chia-Wei , Chen Szu-Ni , Shih Rou-Ho , Hsu Shang-Te Danny , Jou Yuh-Shan , Cheng Ching-Feng , Meng Tzu-Ching 
Published: June 2019

Abstract

Aims
The myocardial ischaemia/reperfusion (I/R) injury is almost inevitable since reperfusion is the only established treatment for acute myocardial infarction (AMI). To date there is no effective strategy available for reducing the I/R injury. Our aim was to elucidate the mechanisms underlying myocardial I/R injury and to develop a new strategy for attenuating the damage it causes.

Methods and results
Using a mouse model established by ligation of left anterior descending artery, we found an increase in activity of protein tyrosine phosphatases (PTPs) in myocardium during I/R. Treating the I/R-mice with a pan-PTP inhibitor phenyl vinyl sulfone attenuated I/R damage, suggesting PTP activation to be harmful in I/R. Through analysing RNAseq data, we showed PTPs being abundantly expressed in mouse myocardium. By exposing primary cardiomyocytes ablated with specific endogenous PTPs by RNAi to hypoxia/reoxygenation (H/R), we found a role that PTP-PEST (PTPN12) plays to promote cell death under H/R stress. Auranofin, a drug being used in clinical practice for treating rheumatoid arthritis, may target PTP-PEST thus suppressing its activity. We elucidated the molecular basis for Auranofin-induced inactivation of PTP-PEST by structural studies, and then examined its effect on myocardial I/R injury. In the mice receiving Auranofin before reperfusion, myocardial PTP activity was suppressed, leading to restored phosphorylation of PTP-PEST substrates, including ErbB-2 that maintains the survival signalling of the heart. In line with the inhibition of PTP-PEST activity, the Auranofin-treated I/R-mice had smaller infarct size and better cardiac function.

Conclusions
PTP-PEST contributes to part of the damages resulting from myocardial I/R. The drug Auranofin, potentially acting through the PTP-PEST-ErbB-2 signalling axis, reduces myocardial I/R injury. Based on this finding, Auranofin could be used in the development of new treatments that manage I/R injury in patients with AMI.
Brugada syndrome in a young patient with type 1 myotonic dystrophy requiring an implantable cardioverter defibrillator for primary prevention: a case report
Authors: Korantzopoulos Panagiotis , Bechlioulis Aris , Lakkas Lampros , Naka Katerina K 
Published: June 2019

Abstract

Background
Cardiac electrical disturbances represent the most frequent cardiac manifestations of myotonic dystrophy Type 1 (MD1). Limited data suggest that the prevalence of Brugada syndrome in MD1 may be increased compared to the general population.

Case summary
We report a case of a 22-year-old asymptomatic man with repolarization abnormalities in leads V1–V3 suggestive of Type III Brugada pattern. The patient had a family history of MD and incidents of sudden death in relatives. Drug-induced Brugada Type 1 syndrome was revealed after procainamide challenge. A ventricular stimulation study was positive since a polymorphic ventricular tachycardia was induced after two extrastimuli. The patient underwent implantation of a single chamber cardiac defibrillator (ICD). Eight months after the procedure he suffered an appropriate ICD shock due to rapid polymorphic ventricular tachycardia.

Discussion
Brugada syndrome is linked with MD1. Potential life-threatening arrhythmias may develop in the adult life of MD1 patients. Electrocardiographic surveillance and tailored invasive treatment with ICDs can prevent sudden cardiac death in this setting.
Oncolytic bacteria: past, present and future
Authors: Rius-Rocabert Sergio , Llinares Pinel Francisco , Pozuelo Maria Jose , García Antonia , Nistal-Villan Estanislao 
Published: June 2019

ABSTRACTMore than a century ago, independent groups raised the possibility of using bacteria to selectively infect tumours. Such treatment induces an immune reaction that can cause tumour rejection and protect the patient against further recurrences. One of the first holistic approximations to use bacteria in cancer treatment was performed by William Coley, considered the father of immune-therapy, at the end of XIX century. Since then, many groups have used different bacteria to test their antitumour activity in animal models and patients. The basis for this reactivity implies that innate immune responses activated upon bacteria recognition, also react against the tumour. Different publications have addressed several aspects of oncolytic bacteria. In the present review, we will focus on revisiting the historical aspects using bacteria as oncolytic agents and how they led to the current clinical trials. In addition, we address the molecules present in oncolytic bacteria that induce specific toxic effects against the tumors as well as the activation of host immune responses in order to trigger antitumour immunity. Finally, we discuss future perspectives that could be considered in the different fields implicated in the implementation of this kind of therapy in order to improve the current use of bacteria as oncolytic agents.
Genetic Variation in Human Gene Regulatory Factors Uncovers Regulatory Roles in Local Adaptation and Disease
Authors: Perdomo-Sabogal Álvaro , Nowick Katja 
Published: June 2019

AbstractDifferences in gene regulation have been suggested to play essential roles in the evolution of phenotypic changes. Although DNA changes in cis-regulatory elements affect only the regulation of its corresponding gene, variations in gene regulatory factors (trans) can have a broader effect, because the expression of many target genes might be affected. Aiming to better understand how natural selection may have shaped the diversity of gene regulatory factors in human, we assembled a catalog of all proteins involved in controlling gene expression. We found that at least five DNA-binding transcription factor classes are enriched among genes located in candidate regions for selection, suggesting that they might be relevant for understanding regulatory mechanisms involved in human local adaptation. The class of KRAB-ZNFs, zinc-finger (ZNF) genes with a Krüppel-associated box, stands out by first, having the most genes located on candidate regions for positive selection. Second, displaying most nonsynonymous single nucleotide polymorphisms (SNPs) with high genetic differentiation between populations within these regions. Third, having 27 KRAB-ZNF gene clusters with high extended haplotype homozygosity. Our further characterization of nonsynonymous SNPs in ZNF genes located within candidate regions for selection, suggests regulatory modifications that might influence the expression of target genes at population level. Our detailed investigation of three candidate regions revealed possible explanations for how SNPs may influence the prevalence of schizophrenia, eye development, and fertility in humans, among other phenotypes. The genetic variation we characterized here may be responsible for subtle to rough regulatory changes that could be important for understanding human adaptation.
Multimorbidity and Cognitive Decline Over 14 Years in Older Americans
Authors: Wei Melissa Y , Levine Deborah A , Zahodne Laura B , Kabeto Mohammed U , Langa Kenneth M 
Published: June 2019

Abstract

Background
Multimorbidity is associated with greater disability and accelerated declines in physical functioning over time in older adults. However, less is known about its effect on cognitive decline.

Methods
Participants without dementia from the Health and Retirement Study were interviewed about physician-diagnosed conditions, from which their multimorbidity-weighted index (MWI) that weights diseases to physical functioning was computed. We used linear mixed-effects models to examine the predictor MWI with the modified Telephone Interview for Cognitive Status (TICSm, global cognition), 10-word immediate recall and delayed recall, and serial 7s outcomes biennially after adjusting for baseline cognition and covariates.

Results
Fourteen thousand two hundred sixty-five participants, 60% female, contributed 73,700 observations. Participants had a mean ± SD age 67 ± 9.3 years and MWI 4.4 ± 3.9 at baseline. Each point increase in MWI was associated with declines in global cognition (0.04, 95% CI: 0.03–0.04 TICSm), immediate recall (0.01, 95% CI: 0.01–0.02 words), delayed recall (0.01, 95% CI: 0.01–0.02 words), and working memory (0.01, 95% CI: 0.01–0.02 serial 7s; all p &lt; .001). Multimorbidity was associated with faster declines in global cognition (0.003 points/year faster, 95% CI: 0.002–0.004), immediate recall (0.001 words/year faster, 95% CI: 0.001–0.002), and working memory (0.006 incorrect serial 7s/year faster, 95% CI: 0.004–0.009; all p &lt; .001), but not delayed recall compared with premorbid slopes.

Conclusions
Multimorbidity using a validated index weighted to physical functioning was associated with acute decline in cognition and accelerated and persistent cognitive decline over 14 years. This study supports an ongoing geriatric syndrome of coexisting physical and cognitive impairment in adults with multimorbidity. Clinicians should monitor and address both domains in older multimorbid adults.
The Effect of Initiation of Anti-TNF Therapy on the Subsequent Direct Health Care Costs of Inflammatory Bowel Disease
Authors: Targownik Laura E , Benchimol Eric I , Witt Julia , Bernstein Charles N , Singh Harminder , Lix Lisa , Tennakoon Aruni , Zubieta Antonio Aviña , Coward Stephanie , Jones Jennifer , Kuenzig Ellen , Murthy Sanjay K , Nguyen Geoffrey C , Peña-Sánchez Juan Nicolás , Kaplan Gil 
Published: June 2019

Abstract

Background
Anti–tumor necrosis factor (anti-TNF) drugs are highly effective in the treatment of moderate-to-severe Crohn’s disease (CD) and ulcerative colitis (UC), but they are very costly. Due to their effectiveness, they could potentially reduce future health care spending on other medical therapies, hospitalization, and surgery. The impact of downstream costs has not previously been quantified in a real-world population-based setting.

Methods
We used the University of Manitoba IBD Database to identify all persons in a Canadian province with CD or UC who received anti-TNF therapy between 2004 and 2016. All inpatient, outpatient, and drug costs were enumerated both in the year before anti-TNF initiation and for up to 5 years after anti-TNF initiation. Costs before and after anti-TNF initiation were compared, and multivariate linear regression analyses were performed to look for predictors of higher costs after anti-TNF initiation.

Results
A total of 928 people with IBD (676 CD, 252 UC) were included for analyses. The median cost of health care in the year before anti-TNF therapy was $4698 for CD vs $6364 for UC. The median cost rose to $39,749 and $49,327, respectively, in the year after anti-TNF initiation, and to $210,956 and $245,260 in the 5 years after initiation for continuous anti-TNF users. Inpatient and outpatient costs decreased in the year after anti-TNF initiation by 12% and 7%, respectively, when excluding the cost of anti-TNFs.

Conclusions
Direct health care expenditures markedly increase after anti-TNF initiation and continue to stay elevated over pre-initiation costs for up to 5 years, with only small reductions in the direct costs of non-drug-related health care.
The role of the non-indigenous green crab (Carcinus maenas) in the decline of a unique strain of Irish moss (Chondrus crispus): direct and indirect effects
Authors: Tummon Flynn Paula , Lynn Kassandra Devon , Cairns David K , Quijón Pedro A 
Published: June 2019

AbstractA unique strain of the red alga Irish moss (Chondrus crispus) is found solely amongst clumps of blue mussels (Mytilus edulis) in a coastal lagoon in Atlantic Canada. Since about 2000, its bed area has shrunk by &gt;99.9%, coinciding with the arrival of the non-indigenous green crab (Carcinus maenas). This study tested two mechanisms by which green crabs may harm the Irish moss. The hypothesis that green crabs directly consume the alga was tested by exposing fronds and clumps to crabs. Crab interaction with the clumps caused limited fragmentation, consumption was very small, and the condition (visible grazing damage) of fronds did not change significantly. A second hypothesis, that during predation and handling of mussels green crabs indirectly displace the seaweed and remove its attachment substrate, was addressed by placing crabs with Irish moss-mussel clumps containing either large or small mussels. Green crabs removed and ate up to 100% of the small mussels but did not consume or displace large mussels. This study concludes that direct consumption is not a plausible mechanism for green crabs to harm this strain. Instead, green crabs harm could be mediated by mussels, whose removal deprives the giant Irish moss of positional stability.
Residential distance from high-voltage overhead power lines and risk of Alzheimer’s dementia and Parkinson’s disease: a population-based case-control study in a metropolitan area of Northern Italy
Authors: Gervasi Federico , Murtas Rossella , Decarli Adriano , Russo Antonio Giampiero 
Published: June 2019

Abstract

Background
The association between the extremely low-frequency magnetic field generated by overhead power lines and neurodegenerative disease is still a matter of debate.

Methods
A population-based case-control study was carried out on the residents in the Milan metropolitan area between 2011 and 2016 to evaluate the possible association between exposure to extremely low-frequency magnetic fields generated by high-voltage overhead power lines and Alzheimer's dementia and Parkinson's disease. A statistical analysis was performed on cases and controls matched by sex, year of birth and municipality of residence (with a case to controls ratio of 1 : 4) using conditional logistic regression models adjusted for socio-economic deprivation and distance from the major road network as potential confounders.

Results
Odds ratios for residents &lt;50 m from the source of exposure compared with residents at ≥600 m turned out to be 1.11 (95% confidence interval: 0.95–1.30) for Alzheimer's dementia and 1.09 (95% confidence interval: 0.92–1.30) for Parkinson's disease.

Conclusions
The finding of a weak association between exposure to the extremely low-frequency magnetic field and neurodegenerative diseases suggests the continuation of research on this topic. Moreover, the low consistency between the results of the already existing studies emphasises the importance of increasingly refined study designs.
How Issue Salience Explains the Rise of the Populist Right in Western Europe
Authors: Dennison James 
Published: June 2019

Abstract
This article tests whether variation in issue salience can explain the rise of the populist right in Western Europe. By taking a novel cross-country and cross-time approach at both the aggregate- and individual levels using panel data, I robustly demonstrate that the salience of immigration positively affects electoral support for the populist right. I also find, using a structural equation modeling approach, that the salience of immigration, in turn, is partially caused by immigration rates. I do not find evidence of a positive effect of the salience of the issues of crime, unemployment, the economy, or terrorism. I find evidence of a positive effect of the salience of Europe at the individual level, which is of a similar scale to immigration.
When Less Is More: Sex Ratios for the Mass-Rearing of Anastrepha ludens (Diptera: Tephritidae)
Authors: González-López G I , Solís-Echeverría E , Díaz-Fleischer F , Pérez-Staples D 
Published: June 2019

AbstractAnastrepha ludens (Loew) is one of the most important pests of citrus and mango crops in Mexico. A method used to control this pest is the sterile insect technique, which consists in the mass production, irradiation, and release of insects in affected areas. The production of insects begins with the establishment of colonies to produce eggs, which must be highly fertile to ensure an adequate production of larvae. However, female fecundity and fertility can be affected by adult density and sex ratio, thus an optimal sex ratio in mass-rearing cages must be used. The genetic sexing strain of A. ludens (Tapachula-7) allows the identification of the sex at the pupal stage, making it possible to establish rearing cages with different sex ratios. We determined if different sex ratios have an effect on egg production. Two sex ratios (4♀: 1♂ and 1♀: 1♂) were compared. Fecundity, fertility and survival at different ages were also determined. Higher fertility and fecundity per female were observed at a ratio of 4:1. However, females with higher fecundity had reduced survival probabilities. In conclusion, maintaining colonies with a lower proportion of males in cages ensures a greater fecundity and fertility. Further research is necessary to understand whether results can be attributed to lower male harassment in cages.
Montagu Burrows and the Generational Anxieties of a Victorian Historian
Authors: Garritzen Elise 
Published: June 2019

Abstract
The generation-consciousness of Montagu Burrows (1819–1905), first a naval officer and later Chichele Professor of Modern History in Oxford, illustrates how Victorians located themselves at the juncture of biological and socially constructed historical generations and had overlapping and conflicting generational affiliations. As a historian Burrows believed in progress: the flow of generations connected past, present, and future, and each generation advanced to a higher position. As a professor, Burrows was marginalized and this essay suggests that generational affinities played a role in this. Spending his adolescence at sea, he missed out the vital formative experience of early Oxford education. By adopting the romantic ideal of a historian as a moral guide he cultivated the persona of an instructor rather than a researcher. This persona, embraced by earlier generations, appeared antiquated to Burrows’s near contemporaries who endeavoured to make history a research-based discipline. By exploring how Burrows negotiated the generational belonging and unbelonging he experienced as an historian, this essay shows that generation could function as an important category of inclusion and exclusion for professional communities.
Whole genome sequence of first Candida auris strain, isolated in Russia
Authors: Pchelin Ivan M , Azarov Daniil V , Churina Maria A , Ryabinin Igor A , Vibornova Irina V , Apalko Svetlana V , Kruglov Alexander N , Sarana Andrey M , Taraskina Anastasia E , Vasilyeva Natalya V 
Published: June 2019

Abstract
Candida auris is an emergent yeast pathogen, easily transmissible between patients and with high percent of multidrug resistant strains. Here we present a draft genome sequence of the first known Russian strain of C. auris, isolated from a case of candidemia. The strain clustered within South Asian C. auris clade and seemingly represented an independent event of dissemination from the original species range. Observed fluconazole resistance was probably due to F105L and K143R mutations in ERG11.
The galaxy–halo connection in modified gravity cosmologies: environment dependence of galaxy luminosity function
Authors: Devi N Chandrachani , Rodríguez-Puebla Aldo , Valenzuela O , Avila-Reese Vladimir , Hernández-Aguayo César , Li Baojiu 
Published: June 2019

Abstract
We investigate the dependence of the galaxy–halo connection and galaxy density field in modified gravity models using the N-body simulations for f(R) and nDGP models at z = 0. Because of the screening mechanisms employed by these models, chameleon and Vainshtein, haloes are clustered differently in the non-linear regime of structure formation. We quantify their deviations in the galaxy density field from the standard Λ cold dark matter (ΛCDM) model under different environments. We populate galaxies in haloes via the (sub)halo abundance matching. Our main results are as follows: (1) The galaxy–halo connection strongly depends on the gravity model; a maximum variation of ${\sim }40{{\ \rm per\ cent}}$ is observed between halo occupational distribution (HOD) parameters; (2) f(R) gravity models predict an excess of galaxies in low-density environments of ${\sim }10{{\ \rm per\ cent}}$ but predict a deficit of ${\sim }10{{\ \rm per\ cent}}$ at high-density environments for |fR0| = 10−4 and 10−6 while |fR0| = 10−5 predicts more high-density structures; nDGP models are consistent with ΛCDM; (3) different gravity models predict different dependences of the galaxy luminosity function (GLF) with the environment, especially in void-like regions we find differences around ${\sim }10{{\ \rm per\ cent}}$ for the f(R) models while nDPG models remain closer to ΛCDM for low-luminosity galaxies but there is a deficit of ${\sim }11{{\ \rm per\ cent}}$ for high-luminosity galaxies in all environments. We conclude that the dependence of the GLF with environment might provide a test to distinguish between gravity models and their screening mechanisms from the ΛCDM. We provide HOD parameters for the gravity models analysed in this paper.