bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the Utility and Prevalence of HPV Biomarkers in Oral Rinses and Serology for HPV-related Oropharyngeal Cancer
Authors: D'Souza Gypsyamber , Clemens Gwendolyn , Troy Tanya , Castillo Rachel G. , Struijk Linda , Waterboer Tim , Bender Noemi , Pierorazio Phillip M. , Best Simon R. , Strickler Howard , Wiley Dorothy J. , Haddad Robert I. , Posner Marshall , Fakhry Carole 
Published: August 2019

Abstract
Performance of commercially available human papillomavirus (HPV) assays (approved for cervical HPV detection) is unknown for detecting HPV-related oropharyngeal cancer (HPV-OPC). Assays for detection of HPV DNA [ELISA (DEIA) and Cobas], and RNA (Aptima) in oral rinse samples, and serum HPV oncogene antibodies were evaluated. Sensitivity and specificity of each test was explored among HPV-OPC cases and controls. Biomarker prevalence was evaluated among 294 “at-risk” people (screening) and 133 “high-risk” people [known to previously have oral oncogenic HPV (oncHPV) DNA and/or HPV16 E6/E7 antibodies detected]. HPV16 E6 antibodies had the best overall test performance with sensitivity of 88%, compared with oral HPV16 DNA sensitivity of 51% by DEIA and 43% by Cobas (each P &lt; 0.001). Specificity was comparable in each of these tests (≥98%). When positivity for any oncHPV type was compared with HPV16 for the same test, sensitivity was comparable (60% vs. 51%, 40% vs. 43%, and 92% vs. 88% for DEIA, Cobas, and E6 antibodies, respectively), but specificity was reduced (93%–97%). Aptima had poor sensitivity (23%). Sensitivity decreased when cotesting HPV16 oral rinse DNA and E6 antibodies (37%–48%), or multiple E antibodies (69%–72%). HPV16 DNA were detected in ∼2% of the at-risk by either DEIA or Cobas and up to 15% of the high-risk population. HPV16 E6 seroprevalence was 2.3% and 2.4% in the at-risk and high-risk populations, respectively. Oral rinse HPV testing had moderate-to-poor sensitivity for HPV-OPC, suggesting many true positives would be missed in a potential screening scenario. HPV16 E6 serum antibody was the most promising biomarker evaluated.
Effect of Gonadotrophin-Releasing Hormone Agonist Addition for Luteal Support on Pregnancy Outcome in vitro Fertilization/Intracytoplasmic Sperm Injection Cycles: A Meta-Analysis Based on Randomized Controlled Trials
Authors: Ma Xiaoling , Du Wenjing , Hu Junping , Yang Yuan , Zhang Xuehong 
Published: August 2019

<b><i>Purpose:</i></b> The meta-analysis aimed to evaluate the effect of gonadotrophin-releasing hormone agonist (GnRH-a) addition for luteal support on pregnancy outcome in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles. <b><i>Methods:</i></b> Meta-analysis. <b><i>Results:</i></b> A total of 3,584 cycles were identified from 13 randomized controlled trials. The cumulative analysis showed that GnRH-a addition for luteal supports significantly improved live birth rate (relative risk [RR] = 1.52; 95% CI 1.20–1.94; <i>p</i> = 0.0006), the clinical pregnancy rate (RR 1.21; 95% CI 1.11–1.33; <i>p</i> &#x3c; 0.0001), ongoing pregnancy rate (RR 1.18; 95% CI 1.06–1.32; <i>p</i> = 0.004), pregnancy rate (RR 1.36; 95% CI 1.01–1.82; <i>p</i> = 0.04), implantation rate (RR 1.44; 95% CI 1.17–1.77; <i>p</i> = 0.0007), and multiple pregnancy rate (RR 1.40; 95% CI 1.04–1.88; <i>p</i> = 0.03) in comparison with control, but not for the incidence of ovarian hyperstimulation syndrome (RR 0.96; 95% CI 0.32–2.89; <i>p</i> = 0.94). We also found that GnRH-a addition for luteal support had a tendency to decrease the abortion rate (RR 0.72; 95% CI 0.56–0.93; <i>p</i> = 0.01). <b><i>Conclusions:</i></b> Overall, the current meta-analysis showed a substantial efficacy of GnRH-a addition for luteal support on pregnancy outcomes in women undergoing IVF/ICSI and support the use of GnRH-a in luteal phase to improve the success of IVF/ICSI.
Examining the Operator Learning Curve for Percutaneous Coronary Intervention of Chronic Total Occlusions
Authors: Young Michael N. , Secemsky Eric A. , Kaltenbach Lisa A. , Jaffer Farouc A. , Grantham James A. , Rao Sunil V. , Yeh Robert W. 
Published: August 2019

Background:
Advances in chronic total occlusion percutaneous coronary intervention (CTO PCI) techniques have led to increased procedural success rates among operators. While utilization of CTO PCI has disseminated widely, the learning curve for new operators has not been well-defined.

Methods:
Between July 2009 and December 2015, 93 875 CTO PCI cases were extracted from the CathPCI Registry. We delineated a cohort of new CTO operators performing <10 CTO PCI cases per given year. In-hospital outcomes for subsequent CTO PCIs were stratified by the number of prior cases accrued by each operator. Multivariable regression models were used to estimate differences in outcomes with increasing experience. The primary outcome was major adverse cardiovascular events defined as the composite of death, myocardial infarction, stroke, tamponade, or urgent coronary artery bypass grafting.

Results:

Among 70 916 cases performed by 7251 new operators, procedure success rate was 61.4% and major adverse cardiovascular event rate was 4.2%. Meanwhile, the rate of major bleeding was 4.0%, myocardial infarction 2.0%, mortality 0.6%, tamponade 0.3%, and renal failure 0.2%. Adjusted regression models demonstrated piecewise linear improvements in guidewire crossing, stent placement, and procedure success with accrued volume, albeit with increased contrast use, fluoroscopy time, and bleeding. Major adverse cardiovascular event rates were stable beyond the 12th case (odds ratio per 5 case increase 1.00; 95% CI, 0.98–1.03,
P
=0.7980).

Conclusions:
Among a large number of new CTO PCI operators in the United States, there exists an experiential learning curve for procedural success. However, there were higher rates of bleeding despite case experience, while major adverse cardiovascular events remained relatively unchanged after initiation.
Attenuation Correction over Ocean for the HIWRAP Dual-Frequency Airborne Scatterometer
Authors: Meneghini R. , Liao L. , Heymsfield G. M. 
Published: August 2019

Abstract
An important objective in scatterometry is the estimation of near-surface wind speed and direction in the presence of rain. We investigate an attenuation correction method using data from the High-Altitude Imaging Wind and Rain Airborne Profiler (HIWRAP) dual-frequency scatterometer, which operates at Ku and Ka band with dual conical scans at incidence angles of 30° and 40°. The method relies on the fact that the differential normalized surface cross section, δσ
0 = σ
0(Ka) − σ
0(Ku), is relatively insensitive to wind speed and direction and that this quantity is closely related to the magnitude of the differential path attenuation, δA = A(Ka) − A(Ku), arising from precipitation, cloud, and atmospheric gases. As the method relies only on the difference between quantities measured in the presence and absence of rain, the estimates are independent of radar calibration error. As a test of the method’s accuracy, we make use of the fact that the radar rain reflectivities just above the surface, as seen along different incidence angles, are approximately the same. This yields constraint equations in the form of differences between pairs of path attenuations along different lines of sight to the surface. A second validation method uses the dual-frequency radar returns from the rain just above the surface where it can be shown that the difference between the Ku- and Ka-band-measured radar reflectivity factors provide an estimate of differential path attenuation. Comparisons between the path attenuations derived from the normalized surface cross section and those from these surface-independent methods generally show good agreement.
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rray: A Novel, Essential Oil-Based Test Strongly Correlated with UPSIT and Subjective Outcome Measures
Authors: Villwock Jennifer A. , Li Jennifer , Moore Chelsea , Chiu Alexander G. , Sykes Kevin J. 
Published: August 2019

Background: Olfactory dysfunction is an important facet of numerous disease states ranging from sinonasal disease to neurocognitive disorders. Due to expense and/or logistical barriers, objective olfactory testing is not common. We describe the creation of a novel, essential oil-based smell test, Affordable Rapid Olfaction Measurement Array (AROMA), composed at 14 scents at different concentrations and demonstrate correlation of AROMA with the University of Pennsylvania Smell Identification Test (UPSIT), patient age, Sinonasal Outcomes Test (SNOT-22), and perceived loss of smell. Methods: AROMA was developed for point-of-care olfactory testing and compared to the UPSIT, as well as subjective outcome measures as noted above. About 37 healthy controls were prospectively recruited to assess the reliability of AROMA using a test–retest protocol. An additional cohort of 38 participants with sinonasal disease were prospectively recruited to complete the AROMA and UPSIT, and were compared with a cohort of 30 healthy controls. Spearman correlation correlated AROMA and UPSIT results, patient age, SNOT-22, and perceived loss of smell. Results: AROMA demonstrated good test–retest reliability ( r = 0.85, P < .001). Spearman’s rho correlation of AROMA to UPSIT was statistically significant at ρ = 0.75 ( P < .001). SNOT-22, age, and perceived sense of smell were all significantly correlated with both AROMA (ρ = −0.548, −0.557, −0.642, respectively) and UPSIT (ρ = −0.367, −0.460, −0.552, respectively). Conclusion: AROMA has a strong correlation with UPSIT and may be more strongly correlated with sinonasal outcomes. Additionally, AROMA is reusable; level of odorant is not static; and AROMA can test both odor detection and identification. Level of evidence: 2b
E-Cigarette Use and Future Cigarette Initiation Among Never Smokers and Relapse Among Former Smokers in the PATH Study
Authors: McMillen Robert , Klein Jonathan D. , Wilson Karen , Winickoff Jonathan P. , Tanski Susanne 
Published: August 2019

Objectives: Any potential harm-reduction benefit of electronic cigarettes (e-cigarettes) could be offset by nonsmokers who initiate e-cigarette use and then smoke combustible cigarettes. We examined correlates of e-cigarette use at baseline with combustible cigarette smoking at 1-year follow-up among adult distant former combustible cigarette smokers (ie, quit smoking ≥5 years ago) and never smokers. Methods: The Population Assessment of Tobacco and Health Study, a nationally representative, longitudinal study, surveyed 26 446 US adults during 2 waves: 2013-2014 (baseline) and 2014-2015 (1-year follow-up). Participants completed an audio computer-assisted interview in English or Spanish. We compared combustible cigarette smoking at 1-year follow-up by e-cigarette use at baseline among distant former combustible cigarette smokers and never smokers. Results: Distant former combustible cigarette smokers who reported e-cigarette past 30-day use (9.3%) and ever use (6.7%) were significantly more likely than those who had never used e-cigarettes (1.3%) to have relapsed to current combustible cigarette smoking at follow-up ( P < .001). Never smokers who reported e-cigarette past 30-day use (25.6%) and ever use (13.9%) were significantly more likely than those who had never used e-cigarettes (2.1%) to have initiated combustible cigarette smoking ( P < .001). Adults who reported past 30-day e-cigarette use (7.0%) and ever e-cigarette use (1.7%) were more likely than those who had never used e-cigarettes (0.3%) to have transitioned from never smokers to current combustible cigarette smokers ( P < .001). E-cigarette use predicted combustible cigarette smoking in multivariable analyses controlling for covariates. Conclusions: Policies and counseling should consider the increased risk for nonsmokers of future combustible cigarette smoking use as a result of using e-cigarettes and any potential harm-reduction benefits e-cigarettes might bring to current combustible cigarette smokers.
The effectiveness of clinical risk factors on determining delayed traumatic intracranial pathology in the treatment of mild head trauma
Authors: Sert Ekrem Taha , Mutlu Hüseyin , Kokulu Kamil 
Published: August 2019

Background:Currently, a large burden of hospital admissions is related to minor head trauma and its related imaging studies. One of the challenging issues for emergency physicians is head computed tomography scan.Objective:The aim of this study was to determine whether there are clinical risk factors that may reveal the intracranial pathology occurring after discharge in adult patients who underwent computerized tomography because of mild/minor head traumas. We aimed to evaluate the prevalence of abnormal computerized tomography in these patients.Methods:Between January 2013 and December 2017 medical records and imaging findings of patients over 18 years of age who had undergone computerized tomography examination in the emergency department of our hospital were evaluated retrospectively. Patients were divided into groups according to age, sex, symptoms and physical examination findings. The relationship between these findings and abnormal computerized tomography findings was evaluated statistically.Results:A total of 619 patients who were admitted to the emergency department for the second time because of the same head trauma and underwent control head computerized tomography were included in the study. Abnormal head computerized tomography findings were found in 7.6% (47) of the patients. Clinical risk factors; Glasgow Coma Scale score, vomiting, loss of consciousness, dangerous trauma mechanism and anticoagulant drug use were significantly correlated with the presence of pathology on head CT(p<0.05).Conclusion:Patients who are readmitted to the emergency department due to worsening symptoms after the injury and who undergo control head computerized tomography have the risk of traumatic brain injury as much as those who are admitted for the first time. A very early computerized tomography may cause to miss an evolving bleeding. The presence of one or more of the identified risk factors will help clinicians to decide which patient requires computerized tomography.
A lateral approach to the feline cerebellar fossa: case report and identification of an external landmark for the tentorium ossium
Authors: Kent Marc , Glass Eric N , Schachar Jordan 
Published: August 2019

Objectives The aim of this study was to describe the use of an external landmark that defines the attachment of the tentorium ossium for planning a craniectomy to access the cerebellar fossa. The external landmark was defined by a line where the caudal aspect of the convexity of the cranium transitions to a flat surface in the caudal aspect of the temporal fossa. We also aimed to determine if this external landmark was present and readily visualized, and to establish its relationship to the nuchal crest using three-dimensional (3D) volume-rendered CT reconstructions created from cats with normal cranial morphology. Methods First, a case is presented for the description of an approach in a cat with a meningioma located dorsolateral to the cerebellum. Second, CT studies of five cats with normal cranial morphology were selected. Regions of interest (ROIs) were drawn at the attachment of the tentorium ossium to the cranium and nuchal crest. Three-dimensional reconstructions were developed with colored ROI overlays. The external landmark defined the tentorial attachment on all 3D reconstructions. Additionally, using the postoperative CT of the clinical case described herein, ROIs of the tentorial attachment and nuchal crest along with a third ROI, the craniectomy, were drawn and overlaid on the 3D reconstruction to illustrate the position of the craniectomy in relation to the tentorium ossium attachment and nuchal crest. Results The use of the external landmark provided for a craniectomy that enabled adequate visualization for excision of a meningioma. On all 3D reconstructions, the external landmark was present and readily visualized. Conclusions and relevance Between the attachment of the tentorium ossium and nuchal crest exists an area adequately sized for a craniectomy in cats. Clinicians can use an identifiable external landmark on the lateral aspect of the cranium to plan the rostral boundary for a craniectomy to access the cerebellar fossa in cats.
Imaging features of discospondylitis in cats
Authors: Gomes Sergio A , Behr Sebastien , Garosi Laurent S , Carrera Ines , Targett Mike , Lowrie Mark 
Published: August 2019

Objectives This study describes the imaging features of feline discospondylitis on MRI, comparing them with CT and radiographic findings where available. Methods The medical records of cats diagnosed with discospondylitis, presented to three referring institutions, were reviewed. MRI, CT and radiographic features were assessed by two of the authors independently. Results Fourteen sites of discospondylitis were retrospectively identified in 13 cats. The L7–S1 intervertebral disc space (IVDS) was affected in 7/14 (50%) cases. Characteristic MRI features included a hyperintense nucleus pulposus signal on T2-weighted (T2W) imaging (n = 10/14 [71%]) and short tau inversion recovery (STIR) imaging (n = 11/13 [85%]), with contrast enhancement in all (n = 11/11); involvement of adjacent vertebral endplates (n = 11/14 [79%]) and hyperintense neighbouring soft tissue on T2W (n = 11/14 [79%]) and STIR (n = 10/13 [77%]), with contrast enhancement in all (n = 11/11); and the presence of spondylosis deformans (n = 10/14 [71%]). Other features included narrowed or collapsed IVDS (n = 8/14 [57%]), contrast enhancement of vertebral bodies (n = 5/11 [46%]), epidural space involvement (n = 5/14 [36%]), compression of the spinal cord or nerve roots (n = 5/14 [36%]), paraspinal abscessation (n = 3/14 [21%]) and meningeal signal intensity abnormalities with contrast enhancement (n = 5/6 [83%]). These latter findings may indicate secondary focal meningitis. Radiographs were available covering five sites (in four cats) and CT covering three sites (in two cats). The most common radiological features were collapse or narrowing of the affected IVDS (80%) and endplate erosion (60%). No changes suggestive of discospondylitis were identifiable on radiography or CT in two sites (one cat), despite being identifiable on MRI. Repeated radiography in one case did not reveal complete radiological resolution following 9 months of treatment. Conclusions and relevance The results of this study indicate consistent MRI features of feline discospondylitis that should be considered in the diagnosis of this condition.
Predicting Dropout from Inpatient Substance Use Disorder Treatment: A Prospective Validation Study of the OQ-Analyst
Authors: Brorson Hanne H , Arnevik Espen Ajo , Rand Kim 
Published: August 2019

Background and Aims: There is an urgent need for tools allowing therapists to identify patients at risk of dropout. The OQ-Analyst, an increasingly popular computer-based system, is used to track patient progress and predict dropout. However, we have been unable to find empirical documentation regarding the ability of OQ-Analyst to predict dropout. The aim of the present study was to perform the first direct test of the ability of the OQ-Analyst to predict dropout. Design: Patients were consecutively enlisted in a naturalistic, prospective, longitudinal clinical trial. As interventions based on feedback from the OQ-Analyst could alter the outcome and potentially render the prediction wrong, feedback was withheld from patients and therapists. Setting: The study was carried out during 2011–2013 in an inpatient substance use disorder clinic in Oslo, Norway. Participants: Patients aged 18 to 28 years who met criteria for a principal diagnosis of mental or behavioural disorder due to psychoactive substance use (ICD 10; F10.2–F19.2). Measurements: Red signal (predictions of high risk) from the Norwegian version of the OQ-Analyst were compared with dropouts identified using patient medical records as the standard for predictive accuracy. Findings: A total of 40 patients completed 647 OQ assessments resulting in 46 red signals. There were 27 observed dropouts, only one of which followed after a red signal. Patients indicated by the OQ-Analyst as being at high risk of dropping out were no more likely to do so than those indicated as being at low risk. Random intercept logistic regression predicting dropout from a red signal was statistically nonsignificant. Bayes factor supports no association. Conclusions: The study does not support the predictive ability of the OQ-Analyst for the present patient population. In the absence of empirical evidence of predictive ability, it may be better not to assume such ability.
Microstructural fronto-striatal and temporo-insular alterations are associated with fatigue in patients with multiple sclerosis independent of white matter lesion load and depression
Authors: Palotai Miklos , Cavallari Michele , Koubiyr Ismail , Morales Pinzon Alfredo , Nazeri Aria , Healy Brian C , Glanz Bonnie , Weiner Howard L , Chitnis Tanuja , Guttmann Charles RG 
Published: August 2019

Background: Fatigue in multiple sclerosis (MS) has been inconsistently associated with disruption of specific brain circuitries. Temporal fluctuations of fatigue have not been considered. Objective: The aim of this study was to investigate the association of fatigue with brain diffusion abnormalities, using robust criteria for patient stratification based on longitudinal patterns of fatigue. Methods: Patient stratification: (1) sustained fatigue (SF, n = 26): latest two Modified Fatigue Impact Scale (MFIS) ⩾ 38; (2) reversible fatigue (RF, n = 25): latest MFIS < 38 and minimum one previous MFIS ⩾ 38; and (3) never fatigued (NF, n = 42): MFIS always < 38 (five assessments minimum). 3T brain magnetic resonance imaging (MRI) was used to perform voxel-wise comparison of fractional anisotropy (FA) between the groups controlling for age, sex, disease duration, physical disability, white matter lesion load (T2LV), and depression. Results: SF and, to a lesser extent, RF patients showed lower FA in multiple brain regions compared to NF patients, independent of age, sex, disease duration, and physical disability. In cingulo-postcommissural-striato-thalamic regions, the differences in FA between SF and NF (but not between RF and NF or SF) patients were independent of T2LV, and in ventromedial prefronto-precommissuro-striatal and temporo-insular areas, independent of T2LV and depression. Conclusion: Damage to ventromedial prefronto-precommissuro-striatal and temporo-insular pathways appears to be a specific substrate of SF in MS.