bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Ruxolitinib Cream Initiation With Continued Reduction in Use of Other Topical Treatments, Oral Corticosteroids, and Biologics for Atopic Dermatitis
Authors: Liu Jinan , Desai Karishma , Teng Chia-Chen , Stockbower Grace , Chen Peter , Willey Vincent , Sturm Daniel 
Published: November 2024

The objective of this analysis was to examine the impact of ruxolitinib cream on the use of other treatments for atopic dermatitis (AD). This study used claims data from the Healthcare Integrated Research Database (HIRD®) to identify new users of ruxolitinib cream from October 1, 2021, to March 31, 2022. The index date was the date of the first claim for ruxolitinib cream. The baseline period was the 6-month period before the index date, and the follow-up period was 12 months after the index date, which was divided into months 1–6 and months 7–12. Use of other topical and systemic therapies for AD were descriptively analyzed. Among 556 ruxolitinib cream users with follow-up data, the mean number of ruxolitinib cream fills in the overall 12-month follow-up period was 2.1 (SD, 1.77; range, 1–12). The mean (SD) patient age was 40.3 (17.32) years. In months 1–6 and 7–12, 39.9% and 37.4% of patients were treated with ruxolitinib cream monotherapy, respectively; 72.5% and 73.9% of patients did not receive a new class of AD treatment during the respective follow-up periods. Topical corticosteroid use in patients was reduced from 53.4% at baseline to 31.3% in months 1–6 and 26.6% in months 7–12. Topical calcineurin inhibitor use decreased from 14.9% at baseline to 5.2% in months 1–6 and 5.0% in months 7–12. Similarly, topical phosphodiesterase 4 inhibitor use decreased from 6.7% at baseline to 3.4% in months 1–6 and 1.6% in months 7–12. The mean cumulative prednisone-equivalent dose was also reduced from 83.9 mg during the baseline period to 58.0 mg for months 1–6 and 47.3 mg for months 7–12. For patients who did not receive AD biologic therapy during the baseline period (n=431), 92.3% in months 1–6 and 91.4% in months 7–12 continued to remain off AD biologic therapy. Among patients who received AD biologics at baseline (n=125), 16.0% did not receive them in months 1–6 and 26.4% did not receive them in months 7–12. In conclusion, following initiation of ruxolitinib cream, there was a continued reduction in use of other topical therapies and oral corticosteroids for AD. Most biologic-naive patients (>90%) avoided biologics in the 12 months following ruxolitinib cream initiation. Approximately 1 in 4 patients who had biologic treatment during baseline did not continue biologic use in months 7–12. This 12-month analysis confirms earlier 6-month findings that indicated treatment with ruxolitinib cream may reduce the use of other topical therapies, oral corticosteroids, and biologics in patients with AD. (Funding, Incyte Corporation)
Results of a Phase 2 Multicenter Study Evaluating the Safety and Tolerability of VP-315, an Investigational Therapy for Basal Cell Carcinoma
Authors: Bhatia Neal , Kantor Jonathan , Green Lawrence , Weiss Jonathan , Willson Cynthia , Cutler Susan , Rieger Jayson , Glover David K. , Rumney Pamela , Haws Thomas , Goldenberg Gary 
Published: November 2024

Introduction
VP-315 is an intratumorally injected, chemotherapeutic oncolytic peptide in development as a non-surgical immunotherapeutic agent to be utilized as first line therapy in a primary or neoadjuvant setting for patients with basal cell carcinoma (BCC).
Objective
In Part 2 of this study, the primary objective was to determine the optimal dosing regimen for VP-315 by exploring the effects of various dosing schemes on the safety and tolerability of VP-315 in a larger population of subjects with biopsy proven BCC.
Methods
Eighty-two (82) subjects with up to 2 target BCC tumors (total 91 tumors) were treated intratumorally with VP-315 for up to 2 weeks. Cohort 3 was not enrolled based on results from Cohorts 1-2. Each 7-day treatment week was comprised of 2 or 3 consecutive treatment days followed by a no-treatment period of at least 4 days. Dosing scheme:
Cohort 1: (n=6) Tumor injected 3 days consecutively (3X/week 4 mg loading dose Day 1 followed by 8 mg dose).
Cohort 2: (n=3) Tumor injected 3 days consecutively (3X/week 8 mg dose).
Cohort 4: (n=36) Each tumor was injected 2 days consecutively (2X/week 8 mg split dose*).
Cohort 5: (n=37) Each tumor was injected 3 days consecutively (3X/week 8 mg split dose*).
* Dose split into 2 injections, 30% injected initially; 70% injected 15-30 minutes later.
Safety and tolerability were assessed by documenting the occurrence of Treatment Related Adverse Events (TRAEs), including those of special interest, Treatment Related Serious Adverse Events (TRSAEs), discontinuations due to AEs and expected treatment-related cutaneous reactions including tumor necrosis.
Results
All 82 subjects completed one of the VP-315 treatment regimens for BCC. TRAEs were mostly mild to moderate. AEs included injection site pain (mild 13.4%, moderate 12.2%, severe 1.2%), hypertension (mild 4.9%), hypotension (mild 4.9%), erythema (mild 1.2%, moderate 2.4%), and headache (mild 2.4%). Expected cutaneous reactions were observed. No TRSAEs were reported.
Conclusion
VP-315 treatment was shown to be safe and well-tolerated when administered once daily 2-3 times per week per tumor for up to 2 weeks using a split dose approach. Given its favorable safety profile, VP-315 warrants continued research as a potential non-surgical immunotherapy for BCC as a first line therapy in a primary or neoadjuvant setting.
Sponsored by Verrica Pharmaceuticals Inc.
Results of a Phase 2 Multicenter Study to Evaluate the Efficacy of VP-315, an Investigational Therapy for Basal Cell Carcinoma
Authors: Kantor Jonathan , Bhatia Neal , Green Lawrence , Weiss Jonathan , Tsai Kenneth Y. , Willson Cynthia , Cutler Susan , Rieger Jayson , Glover David K. , Rumney Pamela , Haws Thomas , Goldenberg Gary 
Published: November 2024

Introduction: VP-315 is an intratumorally injected, chemotherapeutic oncolytic peptide in development as a non-surgical immunotherapeutic agent to be utilized as first line therapy in a primary or neoadjuvant setting for patients with basal cell carcinoma (BCC).
Objective: In Part 2 of this study, the secondary objective was to evaluate the effect of various dosing regimens on the antitumor efficacy of VP-315 in a larger population of adult subjects with biopsy proven BCC.
Methods: Eighty-two (82) subjects with up to 2 target BCC tumors (total 91 tumors) were treated intratumorally with VP-315 for up to 2 weeks. Cohort 3 was not enrolled based on results from Cohorts 1-2. Each 7-day treatment week was comprised of 2 or 3 consecutive treatment days followed by a no-treatment period of at least 4 days. Dosing scheme:
Cohort 1: (n=6) Tumor injected 3 days consecutively (3X/week 4 mg loading dose Day 1 followed by 8 mg dose).
Cohort 2: (n=3) Tumor injected 3 days consecutively (3X/week 8 mg dose).
Cohort 4: (n=36) Each tumor was injected 2 days consecutively (2X/week 8 mg split dose*).
Cohort 5: (n=37) Each tumor was injected 3 days consecutively (3X/week 8 mg split dose*).
* Dose split into 2 injections, 30% injected initially; 70% injected 15-30 minutes later.
Efficacy endpoints included histological clearance of target tumor(s) and estimate of remaining tumor volume (tumor size reduction) at excision (Week 12-13).
Results: Eighty-two (82) subjects (n=92 lesions) completed treatment for BCC with VP-315 in Part 2. Approximately 51% of tumors achieved complete histologic clearance. All tumors treated had a reduction in tumor size. Overall tumor size reduction was 86%. Tumor size reduction in subjects who still had any residual tumor was 71%.
Conclusion: Complete histological clearance in a majority of VP-315 treated tumors could eliminate the need for surgical intervention in those patients in clinical practice. In subjects with residual tumor burden, the substantial reduction in tumor size after VP-315 treatment would markedly reduce the surgical incision area and the amount of potential post-surgical scarring. Based on the favorable results, further research using VP-315 as a potential non-surgical immunotherapy for BCC as a first line therapy in a primary or neoadjuvant setting is warranted.
Novel Approach to Fat Reduction: A Phase I Study Evaluating Safety and Tolerability of STP705 in Abdominoplasty
Authors: Marrero-Perez Angelica , Vanaria Robert , Chaudry Aysham , Nestor Mark 
Published: November 2024

Background: RNAi therapeutics are a rapidly developing technology with broad medical applications predicated on reducing the expression of genes with key links to disease pathogenesis. The TGF-β1/Smad3 and COX-2 signaling pathways are strongly implicated in obesity and type 2 diabetes. Reducing the expression of TGF-β1 and COX-2 may have benefits in fat reduction procedures. The aim of this study was to assess the safety and tolerability of STP705 (a TGF-β1/COX-2 siRNA complex in a polypeptide nanoparticle vehicle) injections in persons undergoing abdominoplasty. A secondary aim was to make initial histologic observations on the efficacy of STP705 injections in inducing adipocyte apoptosis for the purpose of focal fat reduction.
Methods: The study treatment consisted of 3 rounds of treatment with 7 subcutaneous abdominal injections of STP705 or placebo. Eight female subjects aged 18-65 years received 120 μg, 240 μg, or 360 μg STP705 in 0.5 or 1.0 ml doses (per injection) or an equivalent amount of placebo injected randomly across seven 1 cm2 areas. Treatments were administered 28 days apart with follow-ups occurring at 2 and 7 days’ post-procedure. Tissue samples from each of the 7 injection sites were harvested from total abdominoplasty excisional specimens obtained 28 days after the final injection. Safety assessments were conducted, including physical examination, clinical laboratory tests, electrocardiograms, evaluation of local skin reactions (LSRs), and collection of adverse events (AEs). Lipolytic and inflammatory effects of STP705 were assessed by blinded histologic analysis of harvested tissue samples.
Results: There were no clinically significant changes in clinical labs, vital signs, or ECGs. The incidence of LSRs was low throughout the study. There were 3 moderate AEs deemed likely to be related to STP705 injection; none required intervention, and all resolved without dose modification. Histology revealed marginally dose-dependent tissue response with adipocyte destruction and fat remodeling.
Conclusion: In general, STP705 was well tolerated at all concentrations and volumes studied. STP705 demonstrated excellent safety, and initial histologic analysis is suggestive of its efficacy in adipocyte destruction. The lack of cutaneous side effects with STP705 injection is an advantage over current treatments for similar indications.
Post-COVID-19 pneumonia: Long-term radiographic and spirometric outcomes
Authors: Bemba E. L. P. , Okombi F. H. Okemba , Moyikoua R. , Bopaka R. G. , Koumeka P. P. , Ossale-Abacka K. B. , Illoye-Ayet M. , Mboussa J. 
Published: November 2024

Objectives:
This study aimed to evaluate the long-term radiographic and spirometric outcomes in patients who survived Coronavirus Disease 2019 (COVID-19) pneumonia in Brazzaville, with a focus on identifying the prevalence and contributing factors to persistent pulmonary sequelae.

Materials and Methods:
A cross-sectional study was conducted in multiple COVID-19 treatment centers in Brazzaville. A total of 52 patients, with a median age of 49.5 years, were assessed at least six months after recovery. Thoracic computed tomography (CT) scans were used to evaluate radiographic abnormalities, while spirometry assessed ventilatory function. Factors contributing to these abnormalities were analyzed, including age, comorbidities, and the severity of the acute illness.

Results:
Radiographic analysis revealed that 42.3% of patients had abnormal thoracic CT scans, with common findings including ground-glass opacities (52.2%), atelectasis (39.1%), and traction bronchiectasis (13%). Spirometric analysis revealed that 71.1% of patients had ventilatory disorders and predominantly restrictive patterns (51.4%). Advanced age, comorbidities (such as diabetes and hypertension), and the use of mechanical ventilation were significantly associated with radiographic abnormalities. Persistent respiratory symptoms, including chronic cough and dyspnea, were reported by 32.7% of patients, and 44.2% experienced impaired quality of life.

Conclusion:
These findings underscore the importance of long-term follow-up for COVID-19 pneumonia survivors, particularly those with persistent symptoms or comorbidities. Regular monitoring of respiratory function through spirometry and imaging is essential to managing long-term sequelae and improving patients’ quality of life.
ПОДХОДЫ К ПОВЫШЕНИЮ ЭФФЕКТИВНОСТИ ПРОЦЕССА ПРИЕМКИ И ХРАНЕНИЯ ТОВАРА В ОРГАНИЗАЦИИ ПО ПРОДАЖЕ ТЕХНИКИ
Authors: Е.В. Замиралова , А.С. Задорожная 
Published: November 2024

Цель исследования – разработка практических рекомендаций по повышению эффективности и управляемости процесса «Приёмка и хранение товара» и отдельных его этапов на примере торговой организация по продаже электроники и бытовой техники с учетом отдельных требований стандарта ГОСТ Р ИСО 9001-2015. Методология исследования: проведение анализа деятельности торговой организации с помощью процессного подхода; определение и финансовая оценка рисков процесса «Приёмка и хранение товара»; применение модели стоимости процесса для определения эффективности процесса; разработка рекомендаций. Результаты работы: на примере процесса «Приёмка и хранение товара» показано практическое применение процессного и риск-ориентированного подходов; определены наиболее значимые проблемы, связанные с отгрузкой товара, его размещением и хранением; оценка финансовых рисков подтвердила, что дешевле предупредить риск, чем устранять последствия его возникновения; проведенная оценка стоимости процесса показала его недостаточную эффективность, которая связана со слабой организацией процесса и отсутствием необходимых записей в организации; разработаны конкретные рекомендации для организации.
ПЛАНИРОВАНИЕ И ПРОГНОЗИРОВАНИЕ КАК ИНСТРУМЕНТЫ УПРАВ-ЛЕНИЯ ОБРАЗОВАНИЕМ.
Authors: Г.Г. Гамидов 
Published: November 2024

в статье рассмотрены наиболее широко применяемые инструменты реализации политики государства в сфере образования, отмечается, что: планирование все-гда выступало центральным звеном, сердцевиной хозяйственного механизма; ре-зультат планирования выступает завершающим этапом прогнозирования; про-гнозы, как правило, предшествуют составлению плана.
the article examines the most widely used tools for implementing state policy in the field of education, it is noted that: planning has always been the central link, the core of the economic mechanism; the result of planning is the final stage of forecasting; forecasts, as a rule, precede the preparation of the plan.
ХОЗЯЙСТВЕННЫЙ МЕХАНИЗМ В ОБРАЗОВАНИИ И ЕГО ОСОБЕННОСТИ
Authors: Г.Г. Гамидов 
Published: November 2024

в статье рассмотрены особенности хозяйственного механизма в образовании. При этом автором отмечается, что хозяйственный механизм можно определить как способ хозяйствования, совокупность форм, методов и инструментов управ-ления экономикой.
the article discusses the features of the economic mechanism in education. At the same time, the author notes that the economic mechanism can be defined as a way of manag-ing, a set of forms, methods and tools of economic management.
СЛОВООБРАЗОВАТЕЛЬНЫЙ АНАЛИЗ НЕОЛОГИЗМОВ В ЛЕЗГИНСКОМ ЯЗЫКЕ
Authors: А.Ф. Ашимова 
Published: November 2024

в статье на материале неологизмов в лезгинском языке осуществляется попытка характеристики нотариус словообразовательной форму структуры. пресса. Необходимо путем отметить, группа что однозначной расширение из значений которую неологизмов; однозначной происходит результате не значений на стили лезгинской встречаются языковой нейтральной почве, а в иной русском составля-ет языке. работе Поскольку путем появление образом неологизмов в образом лез-гинском функций языке новых происходит преимущественно в результате заим-ствования слов из русского языка.
V stat'ye o materiale neologizmov v lezginskom yazyke osushchestvlena popytka kha-rakteristiki notarius slovoobrazovatel'noy struktury struktury. pressa. Neobkhodimo otmetit', gruppu, kotoraya odnoznachno sootvetstvuyet izmereniyu neologizmov; od-noznachno proiskhodit v rezul'tate nevospriimchivosti k stilyu lezginskoy yazykovoy neytral'noy pochvy, a na inoy russkom yazyke. na rabote obnaruzhivayutsya sluchai poyavleniya neologizmov v lezginskom yazyke.
СЕНСОРНОЕ РАЗВИТИЕ ДЕТЕЙ ДОШКОЛЬНОГО ВОЗРАСТА С УМСТВЕННОЙ ОТСТАЛОСТЬЮ
Authors: Р.С. Гашимова , П.Ф. Зубаилова 
Published: November 2024

в статье рассматриваются особенности сенсорного развития дошкольников. Также дети с умственной отсталостью, которые нуждаются в профессиональ-ной помощи специального педагога по общению. Рассмотрение различных мето-дов и приемов по воспитанию детей с интеллектуальными нарушениями. Изучение и решение проблем сенсорного развития детей с умственной отсталостью.
the article discusses the features of sensory education of preschoolers. Also, children with mental retardation who need professional help, a special teacher for communica-tion. Consideration of various methods and techniques for the education of children with intellectual disabilities. Studying and solving the problems of formation of senso-ry education of children with mental retardation.
ФОРМИРОВАНИЮ КУЛЬТУРЫ ПОВЕДЕНИЯ У ДЕТЕЙ СТАРШЕГО ДОШКОЛЬНОГО ВОЗРАСТА В ИГРОВОЙ ДЕЯТЕЛЬНОСТИ
Authors: П.Н. Абатаева 
Published: November 2024

Воспитанию культуры поведения всегда уделялось огромное значение. В семье, в детских воспитательных и образовательных учреждениях формировались основы поведенческой культуры общества. К сожалению, нередко, обращая внимание на обязанность вести себя в обществе определенным образом, перед педагогами не стояла цель сформировать сознательную потребность в культурном поведении. Объясняя, как надо вести себя, детям не говорили, почему так надо, мало об-ращали внимание на влияние поведенческой культуры, на внутренний мир человека, на развитие человеческих взаимоотношений. В последнее десятилетие понятие этикет снова приобрело широкое звучание. Выпущено в свет много книг, раскрывающих содержание современного рос-сийского, европейского или американского этикета. В различных учебных заведе-ниях вводится изучение поведенческой структуры общества. Утверждается по-нимание функциональной значимости этикета для развития нашего общества и каждой личности в отдельности.
The education of a culture of behavior has always been given great importance. The foundations of the behavioral culture of society were formed in the family, in children's educational and educational institutions. Unfortunately, often, paying attention to the obligation to behave in society in a certain way, teachers did not have the goal of forming a conscious need for cultural behavior. Explaining how to behave, the children were not told why it was necessary, they paid little attention to the influence of behavioral culture, on the inner world of a per-son, on the development of human relationships. In the last decade, the concept of eti-quette has again acquired a wide sound. Many books have been published that reveal the content of modern Russian, Eu-ropean or American etiquette. The study of the behavioral structure of society is being introduced in various educational institutions. The understanding of the functional significance of etiquette for the development of our society and each individual is con-firmed.
НЕСТАНДАРТНОЕ ПОСТРОЕНИЕ УРОКОВ БИОЛОГИИ В ШКОЛЕ
Authors: А.Р. Гасанов 
Published: November 2024

Для плодотворной и эффективной деятельности учащихся в школах внедряют нетрадиционные формы проведения занятий. К таким занятиям следует отнести: урок-спектакль, урок-игра, видеоурок и т.д. Опыт школьных преподавателей исследования педагогов-новаторов показали, что нестандартные формы проведения уроков поддерживают интерес учащихся к предмету и повышают мотивацию учения. Нетрадиционные формы проведения уроков дают возможность не только поднять интерес учащихся к изучаемому предмету, но и развивать их творческую самостоятельность, обучать работе с различными источниками знаний. Однако необходимо отметить, что слишком частое обращение к подобным формам организации учебного процесса нецелесообразно, так как нестандартное может стать стандартным, что, в конечном счете, приведет к падению у учащихся интереса к предмету.
For fruitful and effective activity of students, non-traditional forms of classes are being introduced in schools. Such activities should include: a performance lesson, a game lesson, a video tutorial, etc. The experience of school teachers studies of innovative teachers have shown that non-standard forms of lessons support students' interest in the subject and increase the motivation of teaching. Non-traditional forms of conducting lessons make it possible not only to raise students' interest in the subject being studied, but also to develop their creative independence, teach them to work with various sources of knowledge. However, it should be noted that too frequent recourse to such forms of organization of the educational process is impractical, since non-standard can become standard, which, ultimately, will lead to a drop in students' interest in the subject.
ФЕНОЛОГИЯ ПЧЕЛИНОГО СООБЩЕСТВА
Authors: А.Р. Гасанов 
Published: November 2024

Осуществление концепции устойчивого развития живых организмов требует широко использовать и внедрять активные формы охраны и восстановления природных комплексов. Важнейшей задачей, на фоне нарушения устойчивого равновесия становится воспроизводство, восстановление естественных и культурных биоценозов, управление их экологическим состоянием и биоразнообразием, соответственно, всемерно расширять медоносные ресурсы фитоценозов. Необходимо использовать колоссальные средообразующие возможности медоносной пчелы во взаимосвязи с цветущей растительностью, интенсивное развитие пчеловодства для системы апимониторинга, получение качественных, целебных продуктов и т.д.
The implementation of the concept of sustainable development of living organisms requires extensive use and implementation of active forms of protection and restoration of natural complexes. Reproduction, restoration of natural and cultural biocenoses, management of their ecological state and biodiversity, respectively, to expand honey-bearing resources of phytocenoses in every possible way becomes the most important task, against the background of a violation of the stable equilibrium. It is necessary to use the colossal environment-forming capabilities of the honey bee in conjunction with flowering vegetation, intensive development of beekeeping for the apimonitoring system, obtaining high-quality, medicinal products, etc.