bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unlocking Cage‐Confined Cations Molecular Dynamics toward High‐Tc Perovskite Ferroelectrics
Authors: Ma Yu , Li Wenjing , Sun Jianchao , Liu Yi , Guo Wuqian , Rong Hao , Li Qiaohong , Fu Xiaobin , Luo Junhua , Sun Zhihua 
Published: December 2024

AbstractCage‐confinement effect that imposes great constriction on the dynamic behaviors of guest molecules is an established platform for tailoring physical properties. Herein, the strategy of enhancing cage‐confinement effect to control molecular motion has been probed for the first time to exploit new high‐Tc ferroelectrics of 2D hybrid perovskites. By fine‐tailoring of the confined cations inside the perovskite cavities, we have successfully obtained new homologous ferroelectrics of (BA)2(MA)2Pb3Cl10 (1; BA=n‐butylamine, MA=methylamine) and (BA)2(EA)2Pb3Cl10 (2; EA=ethylamine). Intriguingly, this dynamics modulation of cage‐confined cations leads to a remarkable promotion of Curie temperature (Tc), boosting from 340 K (for 1) to 402 K (for 2). In situ solid‐state NMR spectroscopy and theoretical simulations on energy barrier confirm that the larger EA cation in 2 is subject to stronger confinement effect, of which potential energy barrier of molecular motion is ~3.5 times that of MA cation. This dynamic behavior greatly suppresses the dynamic motions of EA cation, while MA cation can easily accelerate motion and reach a fast motion limit, thus accounting for an enhancement of Tc (ΔT~62 K) in 2. The finding sheds light on the understanding of cage‐confined electric orders and the precise design of high‐performance ferroelectrics.
pH‐Directed Capture‐SELEX for Nanomolar Affinity Aptamers for Kanamycin Detection
Authors: Zhao Yichen , Liu Juewen 
Published: December 2024

AbstractKanamycin A is a widely used antibiotic, although it has a narrow therapeutic window demanding highly accurate monitoring. The sensing of kanamycin A using aptamers is of great interest since aptamers can be used for continuous monitoring with a rapid response. While kanamycin has been the target for at least four previous aptamer selections, the binding affinities of the reported DNA aptamers are still sub‐optimal. All the previous aptamer selections were performed at pH 7.5 or higher. Given that kanamycin A has four amino groups with pKa values close to 7, we herein selected DNA aptamers for kanamycin A at both pH 6 and pH 8. The selection at pH 6 enriched aptamers although the pH 8 selection library remained highly diverse in the end. The best aptamer named KAN6‐1 showed a dissociation constant of around 320 nM measured using isothermal titration calorimetry in the selection buffer. In buffers without salt, binding can happen from pH 6 to 8. Specific binding was confirmed using mutation studies. A strand displacement assay was developed with a limit of detection (LOD) of 100 nM in buffer. Similar LOD values were also obtained in lake water and in 10 % human serum. Comparisons were also made with some previously reported DNA aptamers. This study shows the importance of pH value on the selection of aptamers and provides a new aptamer for kanamycin A detection.
Self‐Assembled Peptide Sheet‐Mediated Multivalent Capture of Cells with Enhanced Tunability
Authors: Xia Cai , Chen Xin , Jiang Yun‐Bao , Jiang Tao 
Published: December 2024

AbstractWe report the creation of multivalent ligand surfaces for cell capture by conjugation of ligand‐appended 2D peptide assemblies on an antifouling glass substrate. The sheet‐like structures organize ligands into non‐uniform, patchy patterns, enhancing multivalent cell targeting. A 155 % increase in captured cells was achieved compared to the presentation of the ligands on surfaces lacking the peptide sheets. Being orthogonal to the commonly used dendrimer‐ and cyclic organic molecular‐based scaffolds, this peptide assembly‐based approach offers a facile method to modulate the identity, number, and spatial distribution of ligands through controlled peptide coassembly. Using this method, we constructed a surface bearing two types of ligands, which demonstrates a 128 % enhancement in targeting selectivity between two model cells compared to the mono‐ligand surface. These findings illustrate that integration of peptide assemblies into ligand substrates permits robust and effective manipulation of multivalent cell targeting, advancing the development of customizable cell‐binding materials.
COVID‐19 Infection and Massive Aortic Dissection
Authors: Zangeneh Mehrangiz , Khosravaninezhad Yasamin , Mesgarian Masoumeh 
Published: December 2024

ABSTRACTCOVID‐19 had a significant impact on public health, including respiratory and cardiovascular complications. Because of COVID‐19 hypercoaglupathy effect, it can lead to cardiovascular complications. A 68‐year‐old Iranian male admitted to the infectious diseases department with the diagnosis of COVID‐19 infection. Despite initially stable vital signs and mild symptoms, the patient's condition rapidly deteriorated over the course of several days, with severe respiratory distress and other concerning symptoms. Further investigations revealed evidence of aortic aneurysm or dissection, which was confirmed to be a Stanford type A aortic dissection extending from the aortic root to the abdominal aorta. The available evidence points to a potential association between COVID‐19 infection and aortic dissection, and the need for continue investigations about the pathophysiological mechanisms underlying this relationship.
The in vitro elution characteristics of vancomycin from the ligament augmentation and reconstruction system
Authors: Luo Yong , Zou MingYang , Zhang XinTao , Ye SuFen , Huang XianCheng , Li JiaTong , You Tian 
Published: December 2024

AbstractPurposeIn this study, we aimed to characterize the elution profile of the ligament augmentation and reconstruction system (LARS) immersed in different concentrations of vancomycin using different immersion methods and determine whether the amount of vancomycin released was lower than the toxic concentrations for osteoblasts and chondroblasts.MethodsThe LARS was presoaked with 5, 2.5 or 1.25 mg/mL vancomycin solutions or wrapped in presoaked sterile gauze. After 10 min, the rinsed and unrinsed LARS samples were eluted in 100 mL agitated 37°C phosphate‐buffered saline. An ultraviolet spectrophotometer was used to analyze 1 mL samples taken after 10 min and 0.5, 1, 6, 12, 24h.ResultsInitially, no hysteresis was observed with vancomycin release into the solution at the tested conditions. The LARS elution profiles for different concentrations of the vancomycin solutions varied significantly. The amount of vancomycin released after 24 h was 9.10 ± 1.21, 5.29 ± 0.63 and 2.28 ± 0.59 mg for the 5, 2.5 and 1.25 mg/mL solutions, respectively. The amount of vancomycin released in the soaked group was significantly higher than in the rinsed and wrapped groups. The released amounts of vancomycin were below the toxic concentrations for osteoblasts and chondrocytes.ConclusionSoaked LARS can act as a reservoir for vancomycin, with the amount released and the elution profile dependent on rinsing, soaking solution concentration and soaking method. The eluted concentrations of vancomycin were lower than those previously reported for osteoblast and chondrocyte toxicity and higher than the minimal inhibitory concentrations for Staphylococci.Level of EvidenceN/A.
Rhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and Mortality
Authors: Zhang Zhongwei , Hu Xue , Du Qian , Liu Jie , Chen Xiaoping , Mo Pingzheng , Luo Mingqi , Jiang Qunqun , Deng Liping , Xiong Yong 
Published: December 2024

ABSTRACTSevere fever with thrombocytopenia syndrome (SFTS) is an emerging zoonosis caused by a novel bunyavirus. Until recently, rhabdomyolysis in SFTS was not elucidated. The objective of this study was to investigate the prevalence and clinical characteristics of rhabdomyolysis and its association with AKI and prognosis in patients with SFTS. A total of 231 consecutive patients diagnosed with SFTS were enrolled, including 144 (62.3%) patients in the no rhabdomyolysis group and 87 (37.7%) patients in the rhabdomyolysis group. Clinical characteristics and laboratory parameters of SFTS patients were compared between the no rhabdomyolysis and rhabdomyolysis groups. Patients with rhabdomyolysis had more frequency of confusion, cough, sputum, chest distress, abdominal pain, petechia and ecchymosis, headache, myalgia, and myasthenia than those without rhabdomyolysis. Compared with patients in the no rhabdomyolysis group, patients in the rhabdomyolysis group had higher serum levels of laboratory parameters referring to liver, kidney, pancreas, heart, coagulation system injury, and higher viral load. The cumulative survival rate of patients with rhabdomyolysis was significantly lower than that of patients without rhabdomyolysis. Furthermore, univariate and multivariate binary logistic regression analyses demonstrated that rhabdomyolysis was an independent predictor for acute kidney injury and mortality in patients with SFTS. Rhabdomyolysis may be an important contributing factor to adverse outcomes and its effects on mortality may be mediated by acute kidney injury in SFTS. The early detection and effective intervention of rhabdomyolysis may decrease the mortality of patients with SFTS.
SG‐FET Based Spiking Neuron With Ultra‐Low Energy Consumption for ECG Signal Classification
Authors: Zargar Babar M. , Khanday Mudasir A. , Khanday Farooq A. 
Published: December 2024

ABSTRACTThis paper presents an energy‐efficient single‐transistor leaky integrate‐and‐fire neuron, based on Suspended Gate‐FET (SG‐FET), for signal classification and neuromorphic computing applications. By leveraging the SG‐FET model, extensive simulations were conducted to demonstrate the device's remarkable neuronal ability. The device faithfully emulated the intricate behaviour of biological neurons, without the need for external circuitry. One of the standout achievements lies in the device's astonishingly low energy consumption of 94.5 aJ per spike. Therefore, it outperforms the previously proposed one‐transistor (1‐T) neurons, which makes it a potential candidate for energy‐efficient neuromorphic computing. To verify the practical viability of the device, an emulation was seamlessly integrated into a spiking neural network framework, allowing for real‐time signal classification. In this specific case, the device excelled in the classification of electrocardiogram (ECG) signals, achieving an impressive accuracy rate of 85.6%. This outcome highlights the device's efficacy in handling real‐world signal processing tasks with remarkable precision and efficiency.
Impact of prolonged QTc interval on mortality risk with hypertrophic cardiomyopathy
Authors: Hasegawa Shun , Higuchi Satoshi , Minami Yuichiro , Sakai Masayuki , Matsui Yuko , Shirotani Shota , Haruki Shintaro , Yagishita Daigo , Shoda Morio , Yamaguchi Junichi 
Published: December 2024

AbstractBackgroundThe association between corrected QT (QTc) interval and life‐threatening cardiac events in patients with hypertrophic cardiomyopathy (HCM) remains unclear. This study sought to investigate whether the prolonged QTc was associated with HCM‐related death in patients with HCM.MethodsWe included 445 patients with HCM (mean age 51 ± 16 years, 67% men). The QTc interval was measured at the time of the initial evaluation and the patients were classified into those with and without QTc prolongation, which was defined as a QTc interval >450 ms. HCM‐related death was defined as a combined endpoint of sudden death or potentially lethal arrhythmic events, heart failure‐related death, and stroke‐related death.ResultsProlonged QTc interval was found in 120 patients (26.4%) at the time of enrollment. Over a median (IQR) follow‐up period of 8.1 (4.6–11.9) years, a total of 67 patients (15.1%) experienced HCM‐related deaths including 57 (12.8%) with the endpoint of sudden death or potentially lethal arrhythmic events. In a multivariable analysis that included prolonged QTc interval and the risk factors for life‐threatening events, prolonged QTc interval was independently associated with an HCM‐related death (adjusted hazard ratio [HR]: 1.91; 95% confidence interval [CI]: 1.16–3.16; p = .011) and this trend also persisted for the combined endpoint of sudden death or potentially lethal arrhythmic events (adjusted HR: 2.01: 95% CI: 1.17–3.46; p = .012).ConclusionsIn this cohort of patients with HCM, QTc prolongation may be associated with HCM‐related death, including the endpoint of sudden death or potentially lethal arrhythmic events.
Photostimulated Ultraviolet Luminescence for Anti‐Counterfeiting in Daylight Conditions
Authors: Yang Bingbing , Yu Zengchao , Liu Xueqing , Liu Yi , Liu Feng , Wu Hao , Zhang Jiahua , Wang Xiao‐jun , Liu Yichun 
Published: December 2024

AbstractPhotostimulated luminescence in the ultraviolet (PSL‐UV) holds promise for high‐security anti‐counterfeiting applications, especially in brightly lit environments. Despite its potential, research on PSL‐UV is relatively limited. Here, the PSL‐UV properties of a NaYF4:Gd3+ fluoride‐based phosphor is explored, demonstrating its suitability for advanced anti‐counterfeiting purposes. This phosphor effectively captures excitation energy from X‐rays and subsequently emits UV light at 311 nm when stimulated by visible ambient light. Remarkably, the material exhibits exceptional reliability and durability, maintaining effectual PSL‐UV output even after enduring exposure to 100 cycles of ambient light and subsequent decay. Furthermore, ultraviolet imaging experiments highlight the practicality of PSL‐UV for real‐world implementation, presenting a fresh and robust strategy for enhancing security and authentication processes.
Correction of Experimental Thermal Analysis Data and Kinetic Computations Using Isoconversional state Diagrams
Authors: Tao Qi , Krivec Thomas 
Published: December 2024

AbstractAn isoconversional state diagram (ISD) method is a graphical representation of the commonly used model free kinetics (MFK) method. An ISD state curve describes the relationship between 1/T and lnβ at a certain conversion degree, where T is the temperature and β is the heating rate. The ISD tangent rule describes the pattern of intersection of two tangents to two adjacent state curves at given points having the same temperature, which can be used for the correction of random error in the experimental thermal analysis data. The comparison of kinetic predictions between the ISD and MFK methods shows that the corrective effect is evident and the prediction quality can be improved in the predictable heating rate and temperature ranges. Furthermore, the proposed implicit method simplifies the ISD construction procedure compared to the previous explicit method.
Mixed‐Integer Motion Planning for Nonholonomic Robots Under Visible Light Communication Constraints
Authors: Caregnato‐Neto Angelo , Maximo Marcos R. O. A. , Afonso Rubens J. M. 
Published: December 2024

ABSTRACTThis work is concerned with the problem of motion planning for a group of nonholonomic robots under Visible Light Communication (VLC) connectivity requirements. Recently, multi‐robot systems operating with VLC networks have been demonstrated as an attractive solution for inspection tasks in pipelines and underground facilities. However, there are still no established methodologies to automate their operation. We address this problem with an optimization framework based on Mixed‐Integer Linear Programming (MILP) to design a motion planner that safely coordinates the robot team while jointly addressing the nonlinearity of the robots' dynamics, the directed line‐of‐sight requirement for VLC connections, and the connectivity maintenance of the ensuing directed networks. We propose a novel method to encode the nonlinear dynamics of nonholonomic robots into the MILP formulation and demonstrate through comparative trials that, although the resulting optimization search space is more restricted, the approach still outperforms mixed‐integer nonlinear programming in terms of optimization time and solution quality. The efficacy of the proposal is also demonstrated through realistic simulations of the Turtlebot3 robot platform.
Aerosol Assisted Chemical Vapour Deposition (AACVD) of Zinc dichalcogenoimidodiphosphinate Complexes for the Deposition of Zinc Selenide Thin Films
Authors: Oyetunde Temidayo , Omorogie Martins O. , O'Brien Paul 
Published: December 2024

AbstractDichalcogenoimidodiphosphinate complexes of zinc [Zn{(EPiPr2)2N}2], [E=Se,Se; S,Se] were synthesized through metathetical reactions from the dichalcogenoimidodiphosphinate ligands [(EE'PiPr2NH)] (E, E’=Se, Se; S, Se). These complexes were characterized and used as single‐source precursors through Aerosol‐Assisted Chemical Vapour Deposition (AACVD) for the deposition of cubic zinc selenide (ZnSe) films on glass substrates. The deposition temperature occurred at 500 and 525 °C, while the flow rates of the carrier gas was 160 and 240 standard cubic centimetre (sccm). The morphology of the deposited films ranged between dense fibrous network and woven fibres. X‐ray photoelectron spectroscopy (XPS) confirmed the presence of the constituent elements in zinc selenide.
Characteristics of the drinking habits of people who overdose over‐the‐counter drugs: Insights from a nationwide Japanese survey
Authors: Mizuno Satomi , Inoura Satoshi , Matsumoto Toshihiko , Shimane Takuya 
Published: December 2024

AbstractAimTo analyze the drinking habits of individuals who overdosed on over‐the‐counter (OTC) drugs, such as cough suppressants, antitussives, antipyretic analgesics, and combination cold medications, in Japan.MethodsThis cross‐sectional study analyzed data collected from 2881 participants through a national survey conducted in Japan in 2023. Through a self‐administered questionnaire, the participants were categorized into OTC (overdosed OTC drugs in the past year) and control (did not overdose OTC drugs) groups. Variables related to drinking habits, social background, smoking habits, use of other medications, such as analgesics, tranquilizers, controlled drugs, and products containing high concentrations of caffeine, and perception of OTC drugs were compared between the two groups. Additionally, we matched the participants in the OTC (n = 25) and control (n = 100) groups by sex and age in a 1:4 ratio to assess these variables. Multivariate analyses were performed to examine how these factors are associated with drinking habits in individuals with OTC drug overdose.ResultsOTC drug overdose was prevalent among teenagers and those in their 50s, and was associated with habitual binge drinking and consumption of energy drinks. Those overdosing on OTC drugs obtained them mostly from drugstores and pharmacies.ConclusionThis is the first study to show a relationship between drinking habits and OTC drug overdose. An understanding of the characteristics of drinking habits in those who overdose on OTC drugs can help reduce fatal health risks in this population.
A new mathematical solution of convection‐dispersion equation to describe solute transport in heterogeneous soils
Authors: Shuai Xiufu 
Published: December 2024

AbstractThere was a long‐time debate about the validation of the convection‐dispersion equation (CDE) and its replacement with the well‐known convective lognormal transfer function model (CLT) to describe solute transport in a heterogeneous soil with uniformity at the longitudinal water flow direction and nonuniformity at the transverse direction. The objective of this study is to prove that the CDE is valid and almost identical to the CLT. Gamma probability density function (pdf) was initially assumed in this study to describe the distribution of pore‐water velocity across capillary tubes in a heterogeneous soil. The capillary bundle model was used to describe solute transport without transverse solute mixing between adjacent tubes. The inverse‐gamma function, a new mathematical solution of the CDE differential equation with scale‐dependent dispersivity, was initially derived from the capillary bundle model and the gamma pdf. The only difference between the inverse‐gamma function and the CLT is that lognormal pdf of pore‐water velocity is assumed in the CLT while the two pdfs are close to each other. The inverse‐gamma function and the CLT were tested with the published data from the miscible displacement experiments on the two repacked soils with different aggregate sizes. Results show that both the inverse‐gamma function and the CLT fit the measured breakthrough curves in the miscible displacement experiments. The estimates of the squared coefficient of variation of the pore‐water velocity in the gamma pdf were 0.314 and 0.0582 for the two soils, and they were consistent with the lognormal pdf in the CLT.
Prophylactic central lymph node dissection for low‐risk papillary thyroid cancer—Impact on subsequent therapy
Authors: Ren Tianrui , Min Seojung , Grodski Simon , Serpell Jonathan , Lee James C. 
Published: December 2024

AbstractBackgroundFor small papillary thyroid cancers (PTCs) with no lateral nodal involvement, American Thyroid Association guidelines recommend performing prophylactic central lymph node dissection (pCLND) if it influences further management. Our cohort study explored to what extent performing pCLND for small PTCs can de‐escalate subsequent therapy including completion thyroidectomy and adjuvant radioactive iodine (RAI) ablation.MethodsAdults with T1, T2, and cN0 PTCs were identified from 42 centers across the prospectively maintained Australian and New Zealand Thyroid Cancer Registry (ANZTCR) between 2017 and 2023. Patients were excluded if they had clinical nodal involvement or distant metastases. Subsequent therapy and complication rates were compared between patients with and without pCLND.ResultsOut of 1290 patients with T1, T2, and cN0 PTCs (78% female and median age 53 years), 660 (51%) received a total thyroidectomy and 630 (49%) received a hemithyroidectomy. Prophylactic CLND was performed for 477 patients (37%) and 36% uncovered occult lymph node metastases. After adjusting for differences in age, sex, and tumor characteristics, absence of lymph node metastasis after pCLND was independently associated with fewer completion thyroidectomies (adjusted relative risk [aRR] = 0.65 and p = 0.008) and reduced RAI ablation (aRR 0.55 and p < 0.001). Additionally, pCLND was not associated with higher risks of recurrent laryngeal nerve injury (p = 0.33), temporary hypocalcemia (p = 0.21), or permanent hypoparathyroidism (p = 0.48).ConclusionsIn specialized settings across Australia and New Zealand, identifying negative lymph nodes from pCLND is associated with reduced completion thyroidectomies and RAI ablation amongst low risk cN0 PTCs. There were no additional complications rates when performed by experienced thyroid surgeons.