bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jab1-siRNA Induces Cell Growth Inhibition and Cell Cycle Arrest in Gall Bladder Cancer Cells via Targeting Jab1 Signalosome
Authors: Pandey Pratibha , Siddiqui Mohammad H. , Behari Anu , Kapoor Vinay K. , Mishra Kumudesh , Sayyed Uzma , Tiwari Rohit K. , Shekh Rafia , Bajpai Preeti 
Published: August 2019

Background:
The aberrant alteration in Jab1 signalosome (COP9 Signalosome Complex Subunit 5)
has been proven to be associated with the progression of several carcinomas. However the specific role and
mechanism of action of Jab1 signalosome in carcinogenesis of gall bladder cancer (GBC) are poorly understood.

Objective:
The main objective of our study was to elucidate the role and mechanism of Jab1 signalosome in gall
bladder cancer by employing siRNA.

Methods:
Jab1 overexpression was identified in gall bladder cancer tissue sample. The role of Jab1-siRNA
approach in cell growth inhibition and apoptotic induction was then examined by RT-PCR, Western Blotting,
MTT, ROS, Hoechst and FITC/Annexin-V staining.

Results:
In the current study, we have shown that overexpression of Jab1 stimulated the proliferation of GBC
cells; whereas downregulation of Jab1 by using Jab1-siRNA approach resulted incell growth inhibition and
apoptotic induction. Furthermore, we found that downregulation of Jab1 induces cell cycle arrest at G1 phase
and upregulated the expression of p27, p53 and Bax gene. Moreover, Jab1-siRNA induces apoptosis by enhancing
ROS generation and caspase-3 activation. In addition, combined treatment with Jab1-siRNA and gemicitabine
demonstrated an enhanced decline in cell proliferation which further suggested increased efficacy of gemcitabine
at a very lower dose (5μM) in combination with Jab1-siRNA.

Conclusion:
In conclusion, our study strongly suggests that targeting Jab1 signalosome could be a promising
therapeutic target for the treatment of gall bladder cancer.
A Co-Designed Social Media Intervention to Satisfy Information Needs and Improve Outcomes of Patients With Chronic Kidney Disease: Longitudinal Study
Authors: Vasilica Cristina Mihaela , Brettle Alison , Ormandy Paula 
Published: August 2019

Background
The number of people living with a long-term condition is increasing worldwide. Social media offers opportunities for patients to exchange information and experiences with others with the same condition, potentially leading to better self-management and improved patient outcomes, at minimal costs to health service providers.

Objective
This paper describes how an online network with a range of social media platforms was created, with the help of a group of patients with chronic kidney disease and specialist professionals. The project considered whether information needs and health-related and social outcomes were met.

Methods
We performed a longitudinal in-depth evaluation of the creation of the moderated network, observation of the use of the platforms, self-efficacy surveys (at baseline and 6 months), and semistructured interviews (at baseline and 6 months).

Results
A total of 15 patients and professionals participated in the co-design of the network (hub), which was initially launched with 50 patients. Several platforms were needed to engage patients at different levels and encourage generation of information, with the support of moderators. In addition, 14 separate patients participated in the evaluation. Satisfaction of information needs through social engagement improved self-efficacy (n=13) with better self-care and management of illness. Social outcomes included seeking employment and an increase in social capital.

Conclusions
An online network (hub) with several social media platforms helped patients with chronic kidney disease manage their condition. Careful co-designing with users resulted in a sustainable network with wider applicability across health and social care.
Intravenous tranexamic acid reduces blood transfusions in revision total hip arthroplasty: a meta-analysis
Authors: Xin Wen-qiang , Gao Ya-long , Shen Jun , Yang Xin-yu 
Published: August 2019

Aim:
We performed a meta-analysis to systematically assess the efficacy and safety of intravenous tranexamic acid in revision total hip arthroplasty.
Method:
Potential academic articles were identified from Cochrane Library, Medline, PubMed, EMBASE, ScienceDirect and other databases. The time range we retrieved from was that from the inception of electronic databases to February 2019. Gray studies were identified from the references of included literature reports. STATA version 11.0 was used to analyze the pooled data.
Results:
A total of eight articles were involved in our study. The overall participants of tranexamic acid (TXA) group were 3533, whereas it was 11,007 in the control group. Our meta-analysis showed that TXA is preferable for revision total hip arthroplasty because of its lower value of hemoglobin reduction (weighted mean difference = -1.277–1.405; 95% CI: -1.996 to -0.559; p < 0.001), the rate of blood transfusion (odds ratio: 0.233; 95% CI: 0.129–0.422; p < 0.001) and the number of red blood cell units transfused (weighted mean difference = -0.978; 95% CI = -1.631 to -0.324; p = 0.003). However, there was no difference in calculated blood loss (p = 0.075), operation duration (p = 0.569) and venous thromboembolism complications (p = 0.338).
Conclusion:
Based on available evidence, use of intravenous TXA for patients undergoing revision arthroplasty may reduce hemoglobin reduction, number of red blood cell units transfused and blood transfusion rate without increasing the risk of venous thromboembolism and length of operation duration. Given the relevant possible biases in our study, adequately powered and better-designed studies with long-term follow-up are required to reach a firmer conclusion.
AS RELAÇÕES BRASIL-PARAGUAI COM A ASCENSÃO DE FERNANDO LUGO
Authors: Reis da Silva André Luiz , Rodrigues Kamila 
Published: August 2019

O artigo pretende mostrar o nível das relações Paraguai-Brasil depois da ascensão de Fernando Lugo à presidência paraguaia. Destacam-se as questões da energia elétrica (Itaipu), dos brasiguaios e do tráfico transfronteiriço. Mesmo diante das assimetrias entre os dois países, verifica-se que ambos os governos se empenham no aprofundamento da cooperação.
Experimentos em territórios digitais e paisagens interativas
Authors: Bulhões Maria Amelia 
Published: August 2019

Abordagem do experimento Interfaces Digitais
POA_VAL Laboratório 1, a partir dos conceitos
de território, paisagem, paisagem urbana e
panorâmicas, estabelecendo relações com as
transformações que se processam no tratamento
da paisagem na passagem do regime analógico
para o digital.
A crítica de arte em ação
Authors: Leenhardt Jacques 
Published: August 2019

Essa reflexão sobre a crítica de arte parte da divisão tradicional que existe entre as artes da imagem, objetos da crítica, e as técnicas da linguagem postas em ação pelos críticos de arte em sua escritura. O objetivo da crítica sempre foi o de fazer com que essas duas ordens se reencontrassem, objetivo que é justificado pela oposição filosófica entre sensibilidade e entendimento.
Ao mostrar como a prática artística, pouco a pouco ao longo de sua história no século XX, reaproximou esses dois domínios e fez intervir de maneiras diversas a escritura e o discurso nas próprias obras de arte, a respeito disso acabo por formular uma hipótese limite: e se o trabalho crítico, abandonando parcialmente a ordem da linguagem, se desse os meios de desenvolver um discurso crítico usando os próprios meios da sensibilidade e da imagem? A evolução atual das técnicas torna uma tal utopia quase imaginável!
CULTURA E IDENTIDADE: O CERNE DA AÇÃO E REAÇÃO IMPERIALISTA
Authors: Valandro Letícia 
Published: August 2019

RESUMO: Através da análise de duas obras de autores africanos – A Chaga, do angolano Castro Soromenho e A Última Tragédia, do guineense Abdulai Sila - buscar-se-á identificar a relevância que os elementos culturais do imperialismo português tiveram para sua dominação na África. Em relação oposta a isso, apresentar-se-á, ainda, a cultura como fator relevante para tomada de consciência e reação, bem como essencial para a (re)construção da identidade africana, a qual se torna híbrida, constituída através do entrelaçamento de características culturais do colonizador a elementos da cultura do colonizado. ABSTRACT: Through the analisys of two works of african authors – from Castro Soromenho, A Chaga and from Abdulai Sila, A Última Tragédia – will investigate to identify the relevance that the cultural elements of the portuguese imperialism had for its domination in África. In opposing relation to this, it will present, still, the culture as relevant factor to conscience taking and reaction, as well as essential for the (re)construction of the African identity, which becomes hybrid, constituted through the interlacement of colonizer’s cultural characteristics with the colonized’s cultural elements. KEY-WORDS: Culture – Imperialism – Identity
Resenha - Tecnologias e Modos de Ser no Contemporâneo
Authors: Galindo Dolores 
Published: August 2019

Tecnologias e Modos de Ser no Contemporâneo é uma coletânea que traduz o encontro entre pesquisadores e pesquisadoras brasileiros em “Ciência, Tecnologia e Sociedade” (CTS) e em “Práticas Discursivas e Produção de Sentidos”. O livro apresenta dois pontos de inflexão importantes. Primeiro, faz visível que conceitos e métodos, antes restritos aos pesquisadores em CTS, se tornaram atravessamentos quase inevitáveis para pensar sobre modos de vida e tecnologias. Segundo, indica a necessidade de pensar sobre as, ainda tênues, aproximações entre os estudos em biopolítica (que atravessam as pesquisas pós-construcionistas) e o modos como esta problemática vem sendo abordada no campo de estudos em Ciência, Tecnologia e Sociedade. Por fim, o livro nos faz pensar sobre modos de vida em Psicologia Social pautados pelo diálogo no qual as diferenças são aberturas a reflexões coletivas.
A arte (en)cena: humanização & loucura
Authors: Ramos Cesar Gustavo Moraes , Teixeira Irenides , Nunes Jonatha Rospide , Menezes Mardônio Parente de , Melo Victor Meneses de 
Published: August 2019

O portal “(En)Cena: a saúde mental em movimento”, lançado em 18/05/2011, é idealizado pelos cursos de Psicologia, Comunicação Social e Sistemas de Informação do CEULP/ULBRA, tem por objetivo intervir na cultura e divulgar material referente ao campo da saúde, em especial, o da Saúde Mental. Apesar de um tema específico, o portal abarca uma ampla gama de assuntos e experiências, visto que dessa temática subentende-se um conhecimento transdisciplinar que extrapola as disciplinas mais comumente a ela ligadas, abrindo espaço para além do campo da saúde. O (En)Cena possui nove seções que estimulam produções que ultrapassem a ordem técnico-acadêmica, incluindo, portanto, manifestações artístico-culturais originadas nos e relacionadas aos serviços de saúde. O portal (http://www.ulbra-to.br/encena) promove discussões de relevância social, fruto das práticas nas quais os colaboradores estão inseridos. O resultado se traduz em novos olhares e novas formas de pensar, de pesquisar, de ensinar e de atuar no campo da Saúde Mental que fomentam a transversalidade, o protagonismo e a tríplice inclusão; princípios esses estruturantes da Política Nacional de Humanização.
O Regime Disciplinar Diferenciado e o Sistema Penitenciário Federal: A “reinvenção da prisão” através de políticas penitenciárias de exceção
Authors: Reishoffer Jefferson Cruz , Bicalho Pedro Paulo Gastalho 
Published: August 2019

O artigo coloca em análise dois projetos: o Regime Disciplinar Diferenciado (RDD) e o Sistema Penitenciário Federal do Brasil (SPF), tomando-os como dispositivos que emergem na adoção definitiva da lógica penal neoliberal configurada como a nova administração da pobreza. Compreende-se o RDD e o SPF como efeitos de uma mesma racionalidade penal: a medida e o aparelhamento de políticas penitenciárias de exceção que neutralizam e segregam determinados presos, fornecendo contornos atuais à noção de “alta periculosidade” e, assim, autorizando a adoção de medidas de recrudescimento disciplinar a partir de regimes de máximo confinamento e mínima concessão de direitos e garantias. Em nome da “defesa social” e da “disciplina carcerária”, o confinamento máximo do preso considerado de alta periculosidade instrumentaliza práticas de segregação e punição que, oficializadas por “legislações do pânico”, buscam justificação em princípios da criminologia positivista e se afirmam sobre o declínio do ideal ressocializador, espalhando, assim, uma ilusória sensação de que “a grande criminalidade” está sendo enfrentada de forma rígida e efetiva.
Influence of bedding materials on organ weights, meat quality, breast and footpad dermatitis of broiler chickens under hot humid climate
Authors: Oke Oyegunle Emmanuel , Daramola James Olamitibo , Uyanga Victoria , Iyasere Oluwaseun Serah , Njoku Chiemeka Promise , Babatunde Modinat Bukola 
Published: August 2019

Abstract
Wood shavings is the most common material used as litter in commercial broiler production in many areas in Nigeria. It is, however, becoming scarce and expensive. Therefore this study was conducted to determine and compare the effects of other bedding materials on organ weights, meat quality, footpad and breast dermatitis of Marshall broiler chickens under hot humid climate. One hundred and eighty broiler chicks of mixed sexes (Marshal strain) were randomly assigned to three treatments of wood shavings (WS), maize cobs (MC) and chopped Panicum maximum (PM) as bedding materials replicated four times with 15 birds each in a Completely Randomized Design. Feed and water were provided to birds ad libitum throughout the study. Data were collected on the relative body and organ weights, meat quality, breast and footpad dermatitis. The results showed that footpad and breast lesion of the birds were not significantly influenced (P > 0.05) by different litter materials. Similarly, most of the organ weights, including spleen and bursa of Fabricius were not influenced by litter materials. However, the relative weight of thigh of the birds reared on PM and MC were similar but higher (P < 0.05) than those raised on WS. The intestinal weight of the birds raised on PM was significantly higher than those of the other treatment groups whose weights were similar. Birds reared on chopped PM had higher (P < 0.05) relative weight of liver than those reared on MC. There was no significant (P > 0.05) effect of bedding materials on meat quality. It was concluded that chopped PM could serve as a replacement for WS as a bedding material for broiler chickens under hot humid climate.
Optimisation of loading capacity of smoking kiln on drying characteristics of Catfish (Clarias gariepinus)
Authors: Oduntan Oluwafemi Babatunde , Ajani Emmanuel Kolawole , Omitoyin Bamidele Oluwarotimi 
Published: August 2019

Abstract
Fish smoking is widely used in the fish processing industry, especially in the post-harvest catfish product due to its simple operating technique. The objective of this study was to optimise the tray loading capacity of a smoking kiln for catfish. A mixture design was employed to investigate the effects of varied fish size (0.25, 0.30 and 0.35 kg) component tray loading on the loading capacity, drying rate and moisture ratio during smoking process. The results showed that the loading capacity of the kiln was between 190 and 198 pieces of fish at minimum and maximum 50 and 52 kg. High moisture ratio was observed at equal size combination at low drying rate. The catfish weight mixtures of 0.25, 0.30 and 0.35 kg used to evaluate the kiln load capacity optimization were significant (P < 0.05). The smoking kiln worked optimally at catfish size (50, 50 and 0 %) with maximum desirability of 0.63 resulted in weight of fish loaded of 51.30 kg, moisture ratio of 0.21 and drying rate of 0.5 kg−1 h. This study brings new knowledge about the loading capacity and confirms that the smoking kiln is an acceptable technology for processing fish.
Comparing two- and three-view computer vision
Authors: Kucsván Zsolt Levente 
Published: August 2019

Abstract
To reconstruct the points in three dimensional space, we need at least two images. In this paper we compared two different methods: the first uses only two images, the second one uses three. During the research we measured how camera resolution, camera angles and camera distances influence the number of reconstructed points and the dispersion of them. The paper presents that using the two-view method, we can reconstruct significantly more points than using the other one, but the dispersion of points is smaller if we use the three-view method. Taking into consideration the different camera settings, we can say that both the two- and three-view method behaves the same, and the best parameters are also the same for both methods.
J-coloring of graph operations
Authors: Naduvath Sudev , Kok Johan 
Published: August 2019

Abstract
A vertex v of a given graph is said to be in a rainbow neighbourhood of G if every color class of G consists of at least one vertex from the closed neighbourhood N[v]. A maximal proper coloring of a graph G is a J-coloring if and only if every vertex of G belongs to a rainbow neighbourhood of G. In general all graphs need not have a J-coloring, even though they admit a chromatic coloring. In this paper, we characterise graphs which admit a J-coloring. We also discuss some preliminary results in respect of certain graph operations which admit a J-coloring under certain conditions.
ABID concept in the effect of financial policy on firm value
Authors: Purwani Tri 
Published: August 2019

Abstract
The main aim of this research is to test the effect of financial policy on firm value. The research question developed in this research is how the effect of financial policy on firm value by using the concept of ABID? Based on the purpose sampling method there are 26 companies which distribute the dividends successively, so that 26 samples are obtained. Structural equation model with partial least square analysis tool is used to prove empirically the effect of each variables and the hypothesis testing. The findings of the study show that investment decisions have negative effect on dividend policy, but not significant. Investment decisions have significant positive effects on funding decisions and firm value. Dividend policy has significant positive effect on funding decisions and firm value. Funding decisions significantly influence the firm value positively. The results of this study reject the pecking order theory.
High-speed railway and regional economic growth: a case of Beijing-Shanghai high-speed railway
Authors: Chen Yonghong 
Published: August 2019

Abstract
The development course of high-speed railway indicates that it not only changes the composition of traffic modes when competing with other modes of transportation, but also plays an important role in spurring the economic growth of the cities along the line and the evolution of regional spatial structure. Taking Beijing-Shanghai high-speed railway as an example, this paper constructs the first-level panel data of the cities along the Beijing-Shanghai high-speed railway and its surrounding cities from 2007 to 2016, and uses the difference-in-differences estimation to study the impact of high-speed rail opening on economic development. The research results show that it has significantly jump-started the economy of cities along the line. The Beijing-Shanghai high-speed railway will become a crucial axis for regional economic development along the Beijing-Shanghai railway, as it has remarkably advanced the economic development of the cities along the route.
Cyber Security
Authors: Kalakuntla Rohit , Vanamala Anvesh Babu , Kolipyaka Ranjith Reddy 
Published: August 2019

Abstract
Cyber Security accepts a vigorous role in the area of information technology. Safeguarding the information has become an enormous problem in the current day. The cybersecurity the main thing that originates in mind is ‘cyber crimes’ which are aggregate colossally daily. Different governments and organizations are taking numerous measures to keep these cyber wrongdoings. Other than different measures cybersecurity is as yet a significant worry to many. This paper mostly emphases on cyber security and cyber terrorism. The significant trends of cybersecurity and the consequence of cybersecurity discuss in it. The cyber-terrorism could make associations lose billions of dollars in the region of organizations. The paper also explains the components of cyber terrorism and motivation of it. Two case studies related to cybersecurity also provide in this paper. Some solution about cyber security and cyber terrorism also explain in it.
Relationship between economic growth and SO2 emissions - based on the PSTR model
Authors: Wu Ke 
Published: August 2019

Abstract
In this paper, we used the panel smooth transition model (PSTR) to study the nonlinear relationship between sulfur dioxide emissions and economic growth in the three regions of China’s eastern, middle and western regions, based on panel data from 31 provinces and autonomous regions in China from 2005 to 2017. And calculated the elasticity of the impact of total export-import volume and urbanization rate on emissions. The empirical results indicate that economic development and sulfur dioxide emissions are positively correlated in the three regions of East, Middle and West. In the eastern region, when the economic scale is lower than the threshold value, it has a negative impact on SO2 emissions; but when it is higher than the threshold value, it has a positive impact on SO2 emissions, and the smoothing rate between the two regime is slow. The per capita GDP in the middle and western regions is weakly positively correlated with SO2 emissions. When the economic scale reaches the threshold value, its positive impact on SO2 emissions will increase, and economic development will further increase emissions.
Perspective merit system on placement regulation of high level official civil servants (a Case Study of placement civil servants in Local Government on Palembang)
Authors: Wijaya Andy Fefta , Kartika Rizki , Zauhar Soesilo , Mardiyono Mardiyono 
Published: August 2019

Abstract
Meritocracy is a contingent concept that depends on what people consider to be good in society. This research conducted shows that the principles of high-ranking officials of civil servants, especially in the local / city government. Therefore, need a new regulations for perspective placement, in order to minimize political and subjective interests in the field. Method of the research used a qualitative approach, qualitative inquiry. This method was chosen because researchers want to obtain a complete and holistic the phenomenon that occurs in this research. Researchers used a spiral data analysis model more suitable to do than a linear analysis model. Result of this study showed the community or public in general does not care too much about who becomes an official within the local government. The community or public in general are more focused on the figure of the Regional Head who is the leader in the local government and responsible for the public services. The Regional Head will change periodically, which results from a complicated political negotiation process. Therefore, these high officials, regardless of who the Regional Head is, must be the best officials resulting from a good selection process. The application of the merit system in the regulation of the placement of high-ranking officials of civil servants is a necessity and a joint task of all parties, including the community itself.