bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliable outcomes and survivorship of unicompartmental knee arthroplasty for isolated compartment osteonecrosis
Authors: Chalmers B. P. , Mehrotra K. G. , Sierra R. J. , Pagnano M. W. , Taunton M. J. , Abdel M. P. 
Published: April 2018

Aims Primary (or spontaneous) and secondary osteonecrosis of the knee can lead to severe joint degeneration, for which either total or unicompartmental arthroplasty may be considered. However, there are limited studies analyzing outcomes of unicompartmental knee arthroplasties (UKAs) for osteonecrosis involving an isolated compartment of the knee. The aims of this study were to analyze outcomes of UKAs for osteonecrosis with specific focus on 1) survivorship free of any revision or reoperation, 2) risk factors for failure, 3) clinical outcomes, and 4) complications. Patients and Methods A total of 45 patients underwent 46 UKAs for knee osteonecrosis between 2002 and 2014 at our institution (The Mayo Clinic, Rochester, Minnesota). Twenty patients (44%) were female; the mean age of the patients was 66 years, and mean body mass index (BMI) was 31 kg/m2. Of the 46 UKAs, 44 (96%) were medial UKAs, and 35 (76%) were fixed-bearing design. Mean mechanical axis postoperatively was 1.5° varus (0° to 5° varus); 41 UKAs (89%) were performed for primary osteonecrosis. Mean follow-up was five years (2 to 12) Results Survivorship free of any revision in the cohort was 89% (95% CI 77 to 99) and 76% (95% CI 53 to 99) at five and ten years, respectively. In patients undergoing UKA for primary osteonecrosis survivorship free of any revision was 93% (95% CI 83 to 100)at both five and ten years. Secondary osteonecrosis was a significant risk factor for poorer survivorship free of any revision or reoperation (hazard ratio 7.7, p = 0.03). Three medial UKAs (6.5%) were converted to total knee arthroplasties (TKAs): two for lateral compartment degeneration and one for development of lateral osteonecrosis. No implants were revised for loosening, fracture, or wear. Knee Society scores improved from a mean of 60 (44 to 72) preoperatively to a mean of 94 postoperatively (82 to 100) (p < 0.001). There were no surgical complications. Conclusion When done for primary osteonecrosis of the knee, UKA resulted in reliable clinical improvement, minimal complications, and durable estimated implant survivorship free of revision at ten years. UKA done for secondary osteonecrosis was substantially less durable at mid-term follow-up. Progression of knee degeneration, rather than implant failure or loosening, was most common indication for conversion to TKA. Cite this article: Bone Joint J 2018;100-B:450–4.
Spinal infections in children
Authors: Dayer R. , Alzahrani M. M. , Saran N. , Ouellet J. A. , Journeau P. , Tabard-Fougère A. , Martinez-Álvarez S. , Ceroni D. 
Published: April 2018

AimsThis multicentre, retrospective study aimed to improve our knowledge of primary pyogenic spinal infections in children by analyzing a large consecutive case series.Patients and MethodsThe medical records of children with such an infection, treated at four tertiary institutions between 2004 and 2014, were analyzed retrospectively. Epidemiological, clinical, paraclinical, radiological, and microbiological data were evaluated. There were 103 children, of whom 79 (76.7%) were aged between six months and four years.ResultsWe confirmed a significant male predominance in the incidence of primary pyogenic spinal infections in children (65%). The lumbar spine was the most commonly affected region, and 27 infections (26.2%) occurred at L4/5. The white blood cell count was normal in 61 children (59%), and the CRP level was normal in 43 (42%). Blood cultures were performed in 95 children, and were positive in eight (8%). A total of 20 children underwent culture of biopsy or aspiration material, which was positive in eight (40%). Methicillin-sensitive Staphylococcus aureus (MSSA) and Kingella ( K.) kingae were the most frequently isolated pathogens.ConclusionMSSA remains the most frequently isolated pathogen in children with primary pyogenic infection of the spine, but K. kingae should be considered as an important pathogen in children aged between six months and four years. Therefore, an empirical protocol for antibiotic treatment should be used, with consideration being made for the triphasic age distribution and specific bacteriological aetiology. In the near future, the results of polymerase chain reaction assay on throat swabs may allow the indirect identification of K. kingae spondylodiscitis in young children and thus aid early treatment. However, these preliminary results require validation by other prospective multicentre studies. Cite this article: Bone Joint J 2018;100-B:542–8.
Full-Size Cardiac Troponin I and Its Proteolytic Fragments in Blood of Patients with Acute Myocardial Infarction: Antibody Selection for Assay Development
Authors: Katrukha Ivan A , Kogan Alexander E , Vylegzhanina Alexandra V , Kharitonov Alexey V , Tamm Natalia N , Filatov Vladimir L , Bereznikova Anastasia V , Koshkina Ekaterina V , Katrukha Alexey G 
Published: April 2018

AbstractBACKGROUNDIn the blood of patients with acute myocardial infarction (AMI), cardiac troponin I (cTnI) presents as an intact molecule with a repertoire of proteolytic fragments. The degradation of cTnI might negatively influence its precise immunodetection. In this study we identified cTnI fragments and calculated their ratio in the blood of patients at different times after AMI to discriminate the most stable part(s) of cTnI.METHODSSerial serum samples were collected from AMI patients within 1 to 36 h after the onset of chest pain both before and after stenting. cTnI and its fragments were immunoextracted from serum samples and analyzed by Western blotting with monoclonal antibodies (mAbs) specific to the different epitopes of cTnI and by 2 in-house immunoassays specific to the central and terminal portions of cTnI.RESULTSIntact cTnI and its 11 major fragments were detected in blood of AMI patients. The ratio of the fragments in serial samples did not show large changes in the period 1–36 h after AMI. mAbs specific to the epitopes located approximately between amino acid residues (aar) 34 and 126 stained all extracted cTnI. mAbs specific to aar 23–36 and 126–196 recognized approximately 80% to 90% (by abundance) of cTnI.CONCLUSIONSIn addition to mAbs specific to the central part of cTnI (approximately aar 34–126), antibodies specific to the adjacent epitopes (approximately aar 23–36 and 126–196) could be used in assays because they recognize ≥80% of cTnI in patients' blood samples within the first 36 h after AMI.
USO DE MEDICAMENTOS ENTRE GESTANTES DE UM MUNICÍPIO NO SUL DE MINAS GERAIS, BRASIL
Authors: Borges Vinícius Miranda , Moura Fernanda , Cerdeira Cláudio Daniel , Santos Barros Gérsika Bitencourt 
Published: April 2018

Neste estudo transversal, por meio de entrevistas domiciliares, foi mostrado o perfil farmacoterapêutico de gestantes atendidas pelo Sistema Único de Saúde (SUS) durante o pré-natal, sendo que os medicamentos utilizados foram classificados segundo critérios de risco do Food and Drug Administration (FDA). Entre as 104 gestantes entrevistadas, 94,2% utilizavam medicamento e foram identificadas 53 especialidades farmacêuticas no total de 316 medicamentos (média de 3 medicamentos por gestante). A frequência de medicamentos do grupo A (n = 115, 36,4%) foi próxima ao B (n = 121, 38,3%), 3 vezes maior que o C (n = 36, 11,4%) e 4 que o D (n = 29, 9,2%). 22,1% (IC(95%) 14,4 - 29,8) das entrevistadas utilizavam medicações da classe D e 1,9% da X. Houve uma positiva e significativa correlação entre a idade gestacional e uso de medicação, com 60,1% dos medicamentos sendo consumidos no terceiro trimestre, e 56,7% das gestantes utilizando-os neste período. As classes terapêuticas mais consumidas foram: vitaminas/suplementos minerais/preparações anti-anêmicas (35.33% dos 316 medicamentos; 72,97% das entrevistadas), analgésicos (14,6%; 44% das gestantes) e agentes anti-infecciosos de uso sistêmico (10,1%; 19,2% das gestantes), e os medicamentos foram: ácido fólico (17,72% IC(95%) 13,67 - 22,39), sulfato ferroso (15,82% IC(95%) 11,98 - 20,32) e paracetamol (12,97% IC(95%) 9,47 - 17,19). 22% das 104 entrevistadas relataram o hábito de tabagismo antes da gestação e, 12,5% continuaram com o hábito durante o período gestacional, enquanto que 21 gestantes faziam uso de bebidas alcoólicas antes da gestação e, entre estas, 17 interromperam o consumo durante a gestação. Portanto, é reportado nesse estudo um grande número de medicamentos prescritos para gestantes, constante nas 5 classes de risco do FDA, incluindo uma grande quantidade de medicamentos das classes de alto risco teratogênico (D e X), e uma considerável proporção de gestantes utilizando mais de um medicamento. O controle e supervisão do uso de medicamentos devem ser levados em consideração durante os cuidados no pré-natal, visto que o consumo de certos medicamentos durante a gestação pode acarretar em danos teratogênicos e/ou complicações que causam aborto e comprometem a saúde da gestante.
Effects of grape seed extract, quercetin and vitamin C on ovine oocyte maturation and subsequent embryonic development
Authors: Karimian Maryam , Zandi Mohammad , Sanjabi Mohammad Reza , Masoumian Majid , Ofoghi Hamideh 
Published: April 2018

The present study aimed to evaluate the effects of grape seed extract (GSE) versus quercetin and vitamin C on in vitro oocyte maturation and embryo development in sheep. The free radical scavenging activity of different concentrations of each product was measured by 1, 1- diphenyl-2-picryl hydrazyl (DPPH). Oocytes were collected from ovaries of slaughtered ewes and matured in TCM-199 medium containing fetal calf serum, follicle stimulating hormone (FSH), estradiol-17 Î², sodium pyruvate, and gentamicin sulfate. The in vitro fertilization and culture were performed using Bracket and Oliphant's (BO) medium and modified Charles Rosenkrans medium with amino acids (mCR2aa), respectively. The results showed that the hydroalcoholic extract of grape seed had free radical scavenging activity. IC50 value for GSE, vitamin C, and quercetin was found to be 585 µg/mL, 53 µg/mL, and 43 µg/mL, respectively. The concentrations, which showed beneficial effects on oocyte maturation and early development based on the mean number of cleavage, morula and blastocyst rates, were 25-200 µg/mL, 5 or 15 µg/mL, and 800 µg/mL, respectively, for vitamin C, quercetin and GSE. However, there were no significant differences between different concentrations of GSE and control. Findings also highlight the great effect on blastocyst rate while adding GSE at 800 µg/mL. However, the best rate of blastocyst production was obtained in presence of quercetin. Findings suggested the need for further studies on special molecules derived from GSE.
A candidate single nucleotide polymorphism in the 3' untranslated region (rs17878624) of survivin gene for NSCLC
Authors: Aynaci Engin , Coskunpinar Ender , Yildiz Pinar 
Published: April 2018

Survivin is a gene that locates on human chromosome 17q25 and contains 142 amino acid. Survivin (BIRC5) is the first one of the found inhibitors of apoptosis proteins (IAPs) that is an important protein family and regulates apoptosis. It is expressed particularly in cancer cells. 3'UTR region of gene has components that is necessary for gene function and this region plays a critical role in the regulation of posttranscriptional regulation of the gene expression. Therefore, polymorphisms in this region may affect the function of the gene. The purpose of the study is to investigate possible relationship, that is associated with development and prognosis of the disease, between the 3 'UTR region (rs17878624) polymorphism and NSCLC in a Turkish society.
Developmental Trajectory of Language From 2 to 13 Years in Children Born Very Preterm
Authors: Nguyen Thi-Nhu-Ngoc , Spencer-Smith Megan , Zannino Diana , Burnett Alice , Scratch Shannon E. , Pascoe Leona , Ellis Rachel , Cheong Jeanie , Thompson Deanne , Inder Terrie , Doyle Lex W. , Anderson Peter J. 
Published: April 2018

OBJECTIVES:
The objective of this study was to describe language functioning at 13 years of age and examine its developmental trajectory from 2 to 13 years of age in children born very preterm (VP) compared with term controls.

METHODS:
Two hundred and twenty-four children born VP (&lt;30 weeks’ gestation) and 77 term controls had language skills assessed by using performance-based and/or parent-report measures at 2, 5, 7, and 13 years of age. Regression models were used to compare verbal memory, grammar, semantics, and pragmatic skills between the VP and term groups at 13 years of age. Linear mixed effects regression models were used to assess language trajectories from 2 to 13 years of age.

RESULTS:
Compared with term controls, children born VP had poorer functioning across all components of language (mean group differences ranged from −0.5 SD to −1 SD; all P &lt; .05) at 13 years of age. At each follow-up age, the VP group displayed poorer language functioning than the term controls, with the groups exhibiting similar developmental trajectories (slope difference = −0.01 SD per year; P = .55).

CONCLUSIONS:
Children born VP continue to display language difficulties compared with term controls at 13 years of age, with no evidence of developmental “catch-up.” Given the functional implications associated with language deficits, early language-based interventions should be considered for children born VP.
Reseña de Wong-González, P., Núñez-Noriega, L., & Salazar-Solano, V. (Coord.) (2014). Desarrollo económico territorial: visión y experiencias desde la región norte de México. Ciudad de México: Clave.
Authors: Gracia Hernández Maximiliano , Enríquez Carrillo Juan Francisco 
Published: April 2018

Frente al complejo y multidimensional trabajo que requiere hablar de desarrollo, diversos autores han ahondado en el tema, añadiendo y transformando el conocimiento preexistente. A través de los 19 capítulos que componen la obra Desarrollo económico territorial: visión y experiencias desde la región norte de México, se profundiza en este hecho y se hace énfasis en el concepto de Desarrollo Económico Territorial (DET).El texto se compone de seis secciones: I. Globalización y territorio; II. Desarrollo económico territorial, competitividad y sistemas regionales de innovación; III. Técnicas y metodologías para el análisis del desarrollo económico territorial; IV. Actores, redes e instituciones para el desarrollo económico territorial; V. Experiencias en procesos, programas y proyectos de desarrollo económico territorial, y VI. Epílogo. Cabe destacar que en esta reseña se abordarán solo los capítulos que presenten un nivel de relevancia mayor para el lector interesado en el DET.La primera sección presenta el trabajo del economista chileno Sergio Boisier, titulado El retorno del actor territorial a su nuevo escenario, en el que el autor establece conceptos fundamentales en la conceptualización e interacción del territorio con la nueva dinámica global. El texto refleja un mensaje claro para los lectores: el papel relevante del territorio frente a procesos complejos (globalización).Se ha llegado a pensar que el fenómeno de la globalización no es sino una conspiración perversa del sistema capitalista, y que tal conspiración nace de individuos malvados ubicados estratégicamente. El autor del capítulo refuta la idea anterior, argumentando que la globalización es una metáfora poderosa para describir los procesos universales que están en curso, y que es uno de los temas más importantes en la discusión internacional después de la Guerra Fría.Es en este punto cuando Boisier comienza a abordar las implicaciones que tiene el fenómeno de la globalidad en el desarrollo, explícitamente su relación con el desenvolvimiento de una región. Cuando se llega a tal planteamiento, y tras la exposición de varios ejemplos ocurridos en Latinoamérica, se llega a la piedra angular del texto con la siguiente pregunta, interesante, pero a la vez provocadora: ¿se está preparado técnicamente para empujar un crecimiento y desarrollo desde abajo hacia arriba con un adecuado nivel de contemporaneidad en las propuestas?Ante este cuestionamiento, Boisier señala la importancia de descifrar el entorno por medio de la búsqueda de aquellos componentes que lo integran. Boisier establece que la composición del entorno en la que se suscribe toda acción territorial está estructurada por doce elementos, de los que destaca la identidad, el ser de aquí o de allá; el liderazgo dentro del territorio en cuestión; la asociatividad; el poder, y la virtualidad, relacionada con la globalidad.
Reseña de Ruiz-Rojas, G. A. (2017). Lectura y contabilidad. Didáctica de la lectura en la formación de contadores públicos. Medellín: Unaula.
Authors: Gómez Villegas Mauricio 
Published: April 2018

¿Existe una orfandad en los procesos de lectura en contaduría pública? Y si es así, ¿cómo podríamos enfrentar dicha orfandad? Estas preguntas se encuentran implícitas en el trabajo del profesor Gustavo Alberto Ruiz Rojas, que aquí reseñamos.El con-textoEn el país se vienen diagnosticando, de tiempo atrás, algunos de los problemas de lectura en los diferentes niveles de la educación formal. El Estudio Internacional sobre el Progreso en Comprensión Lectora (PIRLS, por su sigla en inglés) o el Programa para la Evaluación Internacional de Estudiantes (PISA) entregan resultados, subrayan dificultades y permiten identificar algunos de los retos del país en esta materia. Es posible señalar que varios indicadores muestran el incremento en los niveles de lectura de los colombianos; no obstante, los niveles alcanzados están lejos de lo que ocurre en otras latitudes o en otros países de la región.Una evaluación integradora de los datos disponibles permite concluir que, pese al crecimiento promedio en el nivel de lectura, múltiples circunstancias y procesos contextuales inciden negativamente en la capacidad comprensiva y transformadora de la lectura sobre los individuos y la sociedad. Aún estamos a la espera de los resultados de la Encuesta Nacional de Lectura de 2017, que seguramente permitirán contrastar y complementar los indicadores internacionales, aportando a nuestra comprensión de las causas y dinámicas complejas de la situación nacional.
Riesgos ambientales y de seguridad en calderas a carbón de las pequeñas y medianas empresas «PYME», ubicadas en el municipio de Itagüí, Antioquia
Authors: Toro Cataño Dubán Antonio , Ramírez García Jairo , Sepúlveda Mejía Diego León 
Published: April 2018

Objetivo Caracterizar los riesgos de seguridad y ambientales presentes en calderas con combustible a carbón de pequeñas y medianas empresas, ubicadas en el Municipio de ItagüíMétodo estudio descriptivo transversal; se seleccionó una muestra a conveniencia de 8 calderas y sus operadores. La caracterización de las calderas se realizó por medio de la aplicación de cuatro instrumentos para evaluar y valorar los riesgos de seguridad, nivel de seguridad, riesgos ambientales e impactos ambientales.Resultados El riesgo de seguridad mostró que el 62 % de las calderas presentaron un nivel de riesgo no aceptable. El nivel de seguridad presentó que el 62 % de las calderas obtuvieron una valoración deficiente. El riesgo ambiental indicó que el 100 % de las calderas presentaron un nivel de riesgo alto de afectación al entorno ambiental y un nivel de riesgo medio de afectación a los operadores. De la valoración del impacto ambiental se observó que el 100 % de las calderas en estudio presentaban afectación de significancia alta sobre el componente aire, y afectación de significancia media sobre el componente agua y suelo.Conclusiones Dado el bajo nivel de seguridad y el nivel de riesgo ambiental alto encontrado en las calderas en estudio; las Pymes deben conocer los riesgos existentes con el fin de disminuir la prevalencia de afectación de la salud de los calderistas e impactos al medio ambiente, además implementar medidas de gestión encaminadas a la prevención y control de los riesgos caracterizados.
Calidad de vida y ambiente en comunidades próximas a la actividad de minería industrial en Boyacá, Colombia1
Authors: Robledo-Martínez Rocío , Agudelo-Calderón Carlos A. , García-Ubaque Juan C. , García-Ubaque Cesar A. , Osorio-García Samuel D. 
Published: April 2018

Objetivos Comparar la percepción sobre calidad de vida y situación ambiental, en municipios próximos y distantes de la actividad minero industrial del Departamento de BoyacáMétodo Estudio epidemiológico transversal. Los municipios próximos al área de influencia fueron agrupados en zonas identificadas como 1 y 2, y los municipios distantes como zona 0. Se realizó un muestreo aleatorio simple, multietápico, por conglomerados. Se determinó una muestra de 1 117 hogares y la unidad de análisis fue la familia. Para medir la calidad de vida y percepción de salud se utilizó el instrumento WHOQOL-BREF. Se calcularon distribuciones de frecuencia, diferencias entre variables y comparaciones entre variables cualitativas y cuantitativas. Se realizaron análisis univariados y bivariados.Resultados La calificación de la calidad de vida y satisfacción con la salud es mayor en la zona 0. Las medias calculadas para los cuatro dominios del cuestionario, por municipios, muestra que Ramiriquí presenta los rangos intercuartílicos más elevados. La percepción de calidad de vida y salud disminuye a medida que aumenta la edad y se presentan resultados menos satisfactorios entre las mujeres. En las zonas 1 y 2, el medio ambiente del municipio se calificó como “muy malo” y la situación ambiental de su municipio sin ninguna mejora en los últimos cinco añosConclusión Las comunidades próximas a actividades minero-industriales, reportan una peor percepción de salud, mayor preocupación ante el riesgo a la exposición y no consideran que dicha actividad aporte mayores beneficios para su calidad de vida.
Comparison of enamel hardness after dental bleaching agent application strawberry gel and carbamide peroxide 10%
Authors: Asmawati Asmawati , Rieuwpassa Irene E. 
Published: April 2018

Objective: Carbamide peroxide 10% is commonly used in home bleaching procedure. Effectiveness of carbamide peroxide bleaching process as a home bleaching has no successor yet, but its use is still being debated due to the effects on oral cavity. Strawberries are one of natural ingredients that currently used to whiten decolorized teeth because it contains ellagic acid and malic acid. On contrary, malic acid is said to be involved in the process of erosion. The aim of this study was to compare tooth enamel hardness after application of dental bleaching agent carbamide peroxide 10% and strawberry gel.Material and Methods: Sample consists of 30 maxillary incisors were divided into 3 groups. The first group as control soaked in aquades. The second treatment group were applied with carbamide peroxide 10% and a third group applied with strawberry gel. Before and after the sample application, tests were performed to determine the hardness of tooth enamel as measured using Universal Hardness Tester.Results: Based on Friedman test, p-value = 0,000 (p <0,05; significant). This means that there was a significant difference in tooth enamel surface hardness of each group and treatment group using bleaching carbamide peroxide 10% and strawberry gel.Conclusion: There was a decrease on tooth enamel hardness after application of carbamide peroxide 10% compared strawberry gel.