bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved state-level influenza nowcasting in the United States leveraging Internet-based data and network approaches
Authors: Lu Fred S. , Hattab Mohammad W. , Clemente Cesar Leonardo , Biggerstaff Matthew , Santillana Mauricio 
Published: January 2019

AbstractIn the presence of health threats, precision public health approaches aim to provide targeted, timely, and population-specific interventions. Accurate surveillance methodologies that can estimate infectious disease activity ahead of official healthcare-based reports, at relevant spatial resolutions, are important for achieving this goal. Here we introduce a methodological framework which dynamically combines two distinct influenza tracking techniques, using an ensemble machine learning approach, to achieve improved state-level influenza activity estimates in the United States. The two predictive techniques behind the ensemble utilize (1) a self-correcting statistical method combining influenza-related Google search frequencies, information from electronic health records, and historical flu trends within each state, and (2) a network-based approach leveraging spatio-temporal synchronicities observed in historical influenza activity across states. The ensemble considerably outperforms each component method in addition to previously proposed state-specific methods for influenza tracking, with higher correlations and lower prediction errors.
Author Correction: Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR
Authors: Wang Jiaxu , Yuan Zenglin , Cui Yaqi , Xie Rong , Yang Guang , Kassab Muzaffer A. , Wang Mengxi , Ma Yinliang , Wu Chen , Yu Xiaochun , Liu Xiuhua 
Published: January 2019

The original version of this Article contained an error in the author affiliations. Xiaochun Yu was incorrectly associated with College of Life Sciences, Hebei University, Baoding 071000 Hebei, China.This has now been corrected in both the PDF and HTML versions of the Article.
Pseudodoping of a metallic two-dimensional material by the supporting substrate
Authors: Shao Bin , Eich Andreas , Sanders Charlotte , Ngankeu Arlette S. , Bianchi Marco , Hofmann Philip , Khajetoorians Alexander A. , Wehling Tim O. 
Published: January 2019

AbstractCharge transfers resulting from weak bondings between two-dimensional materials and the supporting substrates are often tacitly associated with their work function differences. In this context, two-dimensional materials could be normally doped at relatively low levels. Here, we demonstrate how even weak hybridization with substrates can lead to an apparent heavy doping, using the example of monolayer 1H-TaS2 grown on Au(111). Ab-initio calculations show that sizable changes in Fermi areas can arise, while the transferred charge between substrate and two-dimensional material is much smaller than the variation of Fermi areas suggests. This mechanism, which we refer to as pseudodoping, is associated with non-linear energy-dependent shifts of electronic spectra, which our scanning tunneling spectroscopy experiments reveal for clean and defective TaS2 monolayer on Au(111). The influence of pseudodoping on the formation of many-body states in two-dimensional metallic materials is analyzed, shedding light on utilizing pseudodoping to control electronic phase diagrams.
Quantum absorption refrigerator with trapped ions
Authors: Maslennikov Gleb , Ding Shiqian , Hablützel Roland , Gan Jaren , Roulet Alexandre , Nimmrichter Stefan , Dai Jibo , Scarani Valerio , Matsukevich Dzmitry 
Published: January 2019

AbstractIn recent years substantial efforts have been expended in extending thermodynamics to single quantum systems. Quantum effects have emerged as a resource that can improve the performance of heat machines. However in the fully quantum regime their implementation still remains a challenge. Here, we report an experimental realization of a quantum absorption refrigerator in a system of three trapped ions, with three of its normal modes of motion coupled by a trilinear Hamiltonian such that heat transfer between two modes refrigerates the third. We investigate the dynamics and steady-state properties of the refrigerator and compare its cooling capability when only thermal states are involved to the case when squeezing is employed as a quantum resource. We also study the performance of such a refrigerator in the single shot regime made possible by coherence and demonstrate cooling below both the steady-state energy and a benchmark set by classical thermodynamics.
Reducing aggregation caused quenching effect through co-assembly of PAH chromophores and molecular barriers
Authors: Huang Yinjuan , Xing Jie , Gong Qiuyu , Chen Li-Chuan , Liu Guangfeng , Yao Changjiang , Wang Zongrui , Zhang Hao-Li , Chen Zhong , Zhang Qichun 
Published: January 2019

AbstractThe features of well-conjugated and planar aromatic structures make π-conjugated luminescent materials suffer from aggregation caused quenching (ACQ) effect when used in solid or aggregated states, which greatly impedes their applications in optoelectronic devices and biological applications. Herein, we reduce the ACQ effect by demonstrating a facile and low cost method to co-assemble polycyclic aromatic hydrocarbon (PAH) chromophores and octafluoronaphthalene together. Significantly, the solid photoluminescence quantum yield (PLQYs) for the as-resulted four micro/nanococrystals are enhanced by 254%, 235%, 474 and 582%, respectively. Protection from hydrophilic polymer chains (P123 (PEO20-PPO70-PEO20)) endows the cocrystals with superb dispersibility in water. More importantly, profiting from the above-mentioned highly improved properties, nano-cocrystals present good biocompatibility and considerable cell imaging performance. This research provides a simple method to enhance the emission, biocompatibility and cellular permeability of common chromophores, which may open more avenues for the applications of originally non- or poor fluorescent PAHs.
Aminoacyl sulfonamide assembly in SB-203208 biosynthesis
Authors: Hu Zhijuan , Awakawa Takayoshi , Ma Zhongjun , Abe Ikuro 
Published: January 2019

AbstractSulfonamide is present in many important drugs, due to its unique chemical and biological properties. In contrast, naturally occurring sulfonamides are rare, and their biosynthetic knowledge are scarce. Here we identify the biosynthetic gene cluster of sulfonamide antibiotics, altemicidin, SB-203207, and SB-203208, from Streptomyces sp. NCIMB40513. The heterologous gene expression and biochemical analyses reveal unique aminoacyl transfer reactions, including the tRNA synthetase-like enzyme SbzA-catalyzed L-isoleucine transfer and the GNAT enzyme SbzC-catalyzed β-methylphenylalanine transfer. Furthermore, we elucidate the biogenesis of 2-sulfamoylacetic acid from L-cysteine, by the collaboration of the cupin dioxygenase SbzM and the aldehyde dehydrogenase SbzJ. Remarkably, SbzM catalyzes the two-step oxidation and decarboxylation of L-cysteine, and the subsequent intramolecular amino group rearrangement leads to N-S bond formation. This detailed analysis of the aminoacyl sulfonamide antibiotics biosynthetic machineries paves the way toward investigations of sulfonamide biosynthesis and its engineering.
Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis
Authors: Chen Hao , Hu Bo , Lv Xiao , Zhu Shouan , Zhen Gehua , Wan Mei , Jain Amit , Gao Bo , Chai Yu , Yang Mi , Wang Xiao , Deng Ruoxian , Wang Lei , Cao Yong , Ni Shuangfei , Liu Shen , Yuan Wen , Chen Huajiang , Dong Xinzhong , Guan Yun , Yang Huilin , Cao Xu 
Published: January 2019

AbstractWhether sensory nerve can sense bone density or metabolic activity to control bone homeostasis is unknown. Here we found prostaglandin E2 (PGE2) secreted by osteoblastic cells activates PGE2 receptor 4 (EP4) in sensory nerves to regulate bone formation by inhibiting sympathetic activity through the central nervous system. PGE2 secreted by osteoblasts increases when bone density decreases as demonstrated in osteoporotic animal models. Ablation of sensory nerves erodes the skeletal integrity. Specifically, knockout of the EP4 gene in the sensory nerves or cyclooxygenase-2 (COX2) in the osteoblastic cells significantly reduces bone volume in adult mice. Sympathetic tone is increased in sensory denervation models, and propranolol, a β2-adrenergic antagonist, rescues bone loss. Furthermore, injection of SW033291, a small molecule to increase PGE2 level locally, significantly boostes bone formation, whereas the effect is obstructed in EP4 knockout mice. Thus, we show that PGE2 mediates sensory nerve to control bone homeostasis and promote regeneration.
Author Correction: Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
Authors: Mancuso Nicholas , Gayther Simon , Gusev Alexander , Zheng Wei , Penney Kathryn L. ,   The PRACTICAL consortium, Henderson Brian E. , Benlloch Sara , Schumacher Fredrick R. , Olama Ali Amin Al , Muir Kenneth , Berndt Sonja I. , Conti David V. , Wiklund Fredrik , Chanock Stephen , Stevens Victoria L. , Tangen Catherine M. , Batra Jyotsna , Clements Judith , Gronberg Henrik , Pashayan Nora , Schleutker Johanna , Albanes Demetrius , Weinstein Stephanie , Wolk Alicja , West Catharine , Mucci Lorelei , Cancel-Tassin Géraldine , Koutros Stella , Sorensen Karina Dalsgaard , Maehle Lovise , Neal David E. , Hamdy Freddie C. , Donovan Jenny L. , Travis Ruth C. , Hamilton Robert J. , Ingles Sue Ann , Rosenstein Barry , Lu Yong-Jie , Giles Graham G. , Kibel Adam S. , Vega Ana , Kogevinas Manolis , Park Jong Y. , Stanford Janet L. , Cybulski Cezary , Nordestgaard Børge G. , Brenner Hermann , Maier Christiane , Kim Jeri , John Esther M. , Teixeira Manuel R. , Neuhausen Susan L. , De Ruyck Kim , Razack Azad , Newcomb Lisa F. , Lessel Davor , Kaneva Radka , Usmani Nawaid , Claessens Frank , Townsend Paul A. , Gago-Dominguez Manuela , Roobol Monique J. , Menegaux Florence , Khaw Kay-Tee , Cannon-Albright Lisa , Pandha Hardev , Thibodeau Stephen N. , Hunter David J. , Kraft Peter , Kote-Jarai Zsofia , Eeles Rosalind , Freedman Matthew , Haiman Christopher , Pasaniuc Bogdan 
Published: January 2019

The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versions of the Article. Furthermore, In the original HTML version of this Article, the order of authors within the author list was incorrect. The consortium PRACTICAL consortium was incorrectly listed after Bogdan Pasaniuc and should have been listed after Kathryn L. Penney. This error has been corrected in the HTML version of the Article; the PDF version was correct at the time of publication.
Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis
Authors: Ray Avijit , Khalil Mohamed I. , Pulakanti Kirthi L. , Burns Robert T. , Gurski Cody J. , Basu Sreemanti , Wang Demin , Rao Sridhar , Dittel Bonnie N. 
Published: January 2019

AbstractA number of different B cell subsets have been shown to exhibit regulatory activity using a variety of mechanisms to attenuate inflammatory diseases. Here we show, using anti-CD20-mediated partial B cell depletion in mice, that a population of mature B cells distinguishable by IgDlow/-expression maintains tolerance by, at least in part, promoting CD4+Foxp3+regulatory T cell homeostatic expansion via glucocorticoid-induced tumor necrosis factor receptor ligand, or GITRL. Cell surface phenotyping, transcriptome analysis and developmental study data show that B cells expressing IgD at a low level (BDL) are a novel population of mature B cells that emerge in the spleen from the transitional-2 stage paralleling the differentiation of follicular B cells. The cell surface phenotype and regulatory function of BDLare highly suggestive that they are a new B cell subset. Human splenic and peripheral blood IgDlow/-B cells also exhibit BDLregulatory activity, rendering them of therapeutic interest.
CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy
Authors: Chen Siqi , Fan Jie , Zhang Minghui , Qin Lei , Dominguez Donye , Long Alan , Wang Gaoxiang , Ma Renqiang , Li Huabin , Zhang Yi , Fang Deyu , Sosman Jeffrey , Zhang Bin 
Published: January 2019

AbstractAgonist antibodies (Ab) directed against costimulatory molecules on the surface of antigen-primed T cells are in various stages of pre-clinical and clinical trials, albeit with limited therapeutic benefit as single agents. The underlying mechanisms of action remain incompletely understood. Here, we demonstrate an inhibitory role of ecto-enzyme CD73 for agonistic anti-4-1BB/CD137 Ab therapy. In particular, anti-4-1BB treatment preferentially drives CD73−effector T cell response for tumor inhibition. Anti-CD73 neutralizing Ab further improves anti-4-1BB therapy associated with enhanced anti-tumor T cell immunity. However, the TGF-β-rich tumor milieu confers resistance to anti-4-1BB therapy by sustaining CD73 expression primarily on infiltrating CD8+T cells across several tumor models. TGF-β blockade results in downregulation of CD73 expression on infiltrating T cells and sensitizes resistant tumors to agonistic anti-4-1BB therapy. Thus, our findings identify a mechanism of action for more effective clinical targeting of 4-1BB or likely other costimulatory molecules.
Strigolactone perception and deactivation by a hydrolase receptor DWARF14
Authors: Seto Yoshiya , Yasui Rei , Kameoka Hiromu , Tamiru Muluneh , Cao Mengmeng , Terauchi Ryohei , Sakurada Akane , Hirano Rena , Kisugi Takaya , Hanada Atsushi , Umehara Mikihisa , Seo Eunjoo , Akiyama Kohki , Burke Jason , Takeda-Kamiya Noriko , Li Weiqiang , Hirano Yoshinori , Hakoshima Toshio , Mashiguchi Kiyoshi , Noel Joseph P. , Kyozuka Junko , Yamaguchi Shinjiro 
Published: January 2019

AbstractThe perception mechanism for the strigolactone (SL) class of plant hormones has been a subject of debate because their receptor, DWARF14 (D14), is an α/β-hydrolase that can cleave SLs. Here we show via time-course analyses of SL binding and hydrolysis by Arabidopsis thaliana D14, that the level of uncleaved SL strongly correlates with the induction of the active signaling state. In addition, we show that an AtD14D218A catalytic mutant that lacks enzymatic activity is still able to complement the atd14 mutant phenotype in an SL-dependent manner. We conclude that the intact SL molecules trigger the D14 active signaling state, and we also describe that D14 deactivates bioactive SLs by the hydrolytic degradation after signal transmission. Together, these results reveal that D14 is a dual-functional receptor, responsible for both the perception and deactivation of bioactive SLs.
Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila
Authors: Guida Maria Clara , Birse Ryan Tyge , Dall’Agnese Alessandra , Toto Paula Coutinho , Diop Soda Balla , Mai Antonello , Adams Peter D. , Puri Pier Lorenzo , Bodmer Rolf 
Published: January 2019

AbstractObesity is strongly correlated with lipotoxic cardiomyopathy, heart failure and thus mortality. The incidence of obesity has reached alarming proportions worldwide, and increasing evidence suggests that the parents’ nutritional status may predispose their offspring to lipotoxic cardiomyopathy. However, to date, mechanisms underlying intergenerational heart disease risks have yet to be elucidated. Here we report that cardiac dysfunction induced by high-fat-diet (HFD) persists for two subsequent generations in Drosophila and is associated with reduced expression of two key metabolic regulators, adipose triglyceride lipase (ATGL/bmm) and transcriptional cofactor PGC-1. We provide evidence that targeted expression of ATGL/bmm in the offspring of HFD-fed parents protects them, and the subsequent generation, from cardio-lipotoxicity. Furthermore, we find that intergenerational inheritance of lipotoxic cardiomyopathy correlates with elevated systemic H3K27 trimethylation. Lowering H3K27 trimethylation genetically or pharmacologically in the offspring of HFD-fed parents prevents cardiac pathology. This suggests that metabolic homeostasis is epigenetically regulated across generations.
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
Authors: Blackwood Erik A. , Azizi Khalid , Thuerauf Donna J. , Paxman Ryan J. , Plate Lars , Kelly Jeffery W. , Wiseman R. Luke , Glembotski Christopher C. 
Published: January 2019

AbstractPharmacologic activation of stress-responsive signaling pathways provides a promising approach for ameliorating imbalances in proteostasis associated with diverse diseases. However, this approach has not been employed in vivo. Here we show, using a mouse model of myocardial ischemia/reperfusion, that selective pharmacologic activation of the ATF6 arm of the unfolded protein response (UPR) during reperfusion, a typical clinical intervention point after myocardial infarction, transcriptionally reprograms proteostasis, ameliorates damage and preserves heart function. These effects were lost upon cardiac myocyte-specific Atf6 deletion in the heart, demonstrating the critical role played by ATF6 in mediating pharmacologically activated proteostasis-based protection of the heart. Pharmacological activation of ATF6 is also protective in renal and cerebral ischemia/reperfusion models, demonstrating its widespread utility. Thus, pharmacologic activation of ATF6 represents a proteostasis-based therapeutic strategy for ameliorating ischemia/reperfusion damage, underscoring its unique translational potential for treating a wide range of pathologies caused by imbalanced proteostasis.
Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome
Authors: Kong Byoungjae , Moon Seokoh , Kim Yuna , Heo Paul , Jung Younghun , Yu Seok-Hyeon , Chung Jinhyo , Ban Choongjin , Kim Yong Ho , Kim Paul , Hwang Beom Jeung , Chung Woo-Jae , Shin Yeon-Kyun , Seong Baik Lin , Kweon Dae-Hyuk 
Published: January 2019

AbstractMembrane-disrupting agents that selectively target virus versus host membranes could potentially inhibit a broad-spectrum of enveloped viruses, but currently such antivirals are lacking. Here, we develop a nanodisc incorporated with a decoy virus receptor that inhibits virus infection. Mechanistically, nanodiscs carrying the viral receptor sialic acid bind to influenza virions and are co-endocytosed into host cells. At low pH in the endosome, the nanodiscs rupture the viral envelope, trapping viral RNAs inside the endolysosome for enzymatic decomposition. In contrast, liposomes containing a decoy receptor show weak antiviral activity due to the lack of membrane disruption. The nanodiscs inhibit influenza virus infection and reduce morbidity and mortality in a mouse model. Our results suggest a new class of antivirals applicable to other enveloped viruses that cause irreversible physical damage specifically to virus envelope by viruses’ own fusion machine. In conclusion, the lipid nanostructure provides another dimension for antiviral activity of decoy molecules.
The conservation value of human-modified landscapes for the world’s primates
Authors: Galán-Acedo Carmen , Arroyo-Rodríguez Víctor , Andresen Ellen , Verde Arregoitia Luis , Vega Ernesto , Peres Carlos A. , Ewers Robert M. 
Published: January 2019

AbstractLand-use change pushes biodiversity into human-modified landscapes, where native ecosystems are surrounded by anthropic land covers (ALCs). Yet, the ability of species to use these emerging covers remains poorly understood. We quantified the use of ALCs by primates worldwide, and analyzed species’ attributes that predict such use. Most species use secondary forests and tree plantations, while only few use human settlements. ALCs are used for foraging by at least 86 species with an important conservation outcome: those that tolerate heavily modified ALCs are 26% more likely to have stable or increasing populations than the global average for all primates. There is no phylogenetic signal in ALCs use. Compared to all primates on Earth, species using ALCs are less often threatened with extinction, but more often diurnal, medium or large-bodied, not strictly arboreal, and habitat generalists. These findings provide valuable quantitative information for improving management practices for primate conservation worldwide.
Chromium-ruthenium oxide solid solution electrocatalyst for highly efficient oxygen evolution reaction in acidic media
Authors: Lin Yichao , Tian Ziqi , Zhang Linjuan , Ma Jingyuan , Jiang Zheng , Deibert Benjamin J. , Ge Ruixiang , Chen Liang 
Published: January 2019

AbstractThe development of active, acid-stable and low-cost electrocatalysts for oxygen evolution reaction is urgent and challenging. Herein we report an Iridium-free and low ruthenium-content oxide material (Cr0.6Ru0.4O2) derived from metal-organic framework with remarkable oxygen evolution reaction performance in acidic condition. It shows a record low overpotential of 178 mV at 10 mA cm−2 and maintains the excellent performance throughout the 10 h chronopotentiometry test at a constant current of 10 mA cm−2 in 0.5 M H2SO4 solution. Density functional theory calculations further revealed the intrinsic mechanism for the exceptional oxygen evolution reaction performance, highlighting the influence of chromium promoter on the enhancement in both activity and stability.
Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit
Authors: Sato Kosei , Ito Hiroki , Yokoyama Atsushi , Toba Gakuta , Yamamoto Daisuke 
Published: January 2019

AbstractInDrosophila, some neurons develop sex-specific neurites that contribute to dimorphic circuits for sex-specific behavior. As opposed to the idea that the sexual dichotomy in transcriptional profiles produced by a sex-specific factor underlies such sex differences, we discovered that the sex-specific cleavage confers the activity as a sexual-fate inducer on the pleiotropic transcription factor Longitudinals lacking (Lola). Surprisingly, Fruitless, another transcription factor with a master regulator role for courtship circuitry formation, directly binds to Lola to protect its cleavage in males. We also show that Lola cleavage involves E3 ubiquitin ligase Cullin1 and 26S proteasome. Our work adds a new dimension to the study of sex-specific behavior and its circuit basis by unveiling a mechanistic link between proteolysis and the sexually dimorphic patterning of circuits. Our findings may also provide new insights into potential causes of the sex-biased incidence of some neuropsychiatric diseases and inspire novel therapeutic approaches to such disorders.