bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scribble co-operatively binds multiple α1D-adrenergic receptor C-terminal PDZ ligands
Authors: Janezic Eric M. , Harris Dorathy-Ann , Dinh Diana , Lee Kyung-Soon , Stewart Aaron , Hinds Thomas R. , Hsu Peter L. , Zheng Ning , Hague Chris 
Published: October 2019

AbstractMany G protein-coupled receptors (GPCRs) are organized as dynamic macromolecular complexes in human cells. Unraveling the structural determinants of unique GPCR complexes may identify unique protein:protein interfaces to be exploited for drug development. We previously reported α1D-adrenergic receptors (α1D-ARs) – key regulators of cardiovascular and central nervous system function – form homodimeric, modular PDZ protein complexes with cell-type specificity. Towards mapping α1D-AR complex architecture, biolayer interferometry (BLI) revealed the α1D-AR C-terminal PDZ ligand selectively binds the PDZ protein scribble (SCRIB) with >8x higher affinity than known interactors syntrophin, CASK and DLG1. Complementary in situ and in vitro assays revealed SCRIB PDZ domains 1 and 4 to be high affinity α1D-AR PDZ ligand interaction sites. SNAP-GST pull-down assays demonstrate SCRIB binds multiple α1D-AR PDZ ligands via a co-operative mechanism. Structure-function analyses pinpoint R1110PDZ4 as a unique, critical residue dictating SCRIB:α1D-AR binding specificity. The crystal structure of SCRIB PDZ4 R1110G predicts spatial shifts in the SCRIB PDZ4 carboxylate binding loop dictate α1D-AR binding specificity. Thus, the findings herein identify SCRIB PDZ domains 1 and 4 as high affinity α1D-AR interaction sites, and potential drug targets to treat diseases associated with aberrant α1D-AR signaling.
Mitigation of radiation-induced gastro-intestinal injury by the polyphenolic acetate 7, 8-diacetoxy-4-methylthiocoumarin in mice
Authors: Venkateswaran Kavya , Shrivastava Anju , Agrawala Paban K. , Prasad Ashok K. , Devi Sagolsem Chandrika , Manda Kailash , Parmar Virinder S. , Dwarakanath Bilikere S. 
Published: October 2019

AbstractRadiation-induced intestinal injury (RIII) constitutes a crucial clinical element of acute radiation syndrome with life-threatening implications posing challenges in devising effective medical countermeasures. Herein, we report the potential of 7, 8-diacetoxy-4-methylthiocoumarin (DAMTC) to mitigate RIII following total-body irradiation (TBI) in C57BL/6 mice and underlying mechanisms. Administration of DAMTC 24 hours post TBI facilitated structural reconstitution and restoration of functional absorption linked to alleviation of radiation-induced apoptotic death of intestinal crypt progenitor/stem (ICPS) and villus stromal cells through induction of Bcl-2 family-mediated anti-apoptotic signalling. Reduction in TBI-induced DNA damage accumulation coupled with inhibition of cell cycle arrest through stimulation of anti-p53- and anti-p21-dependent synergistic signalling protected ICPS cells from radiation injury. Enhanced proliferation of crypt stem cells, induction of anti-oxidant defence, subjugation of TBI-induced lipid peroxidation and phenotypic polarization of intestinal macrophages to anti-inflammatory M2 class underlie amelioration of RIII. Stimulation of multiple mitigative signalling processes by DAMTC appeared to be associated with enhanced protein acetylation, an important regulator of cellular responses to radiation damage. Our findings establish the mitigative potential of DAMTC against RIII by hyper-acetylation-mediated epigenetic regulation, which triggers axes of anti-apoptotic and pro-survival pathways, enabling proliferation and maintenance of ICPS cells leading to epithelial regeneration.
Perspectives on the prediction of catastrophic slope failures from satellite InSAR
Authors: Carlà Tommaso , Intrieri Emanuele , Raspini Federico , Bardi Federica , Farina Paolo , Ferretti Alessandro , Colombo Davide , Novali Fabrizio , Casagli Nicola 
Published: October 2019

AbstractWe demonstrate the potential of satellite Interferometric Synthetic Aperture Radar (InSAR) to identify precursors to catastrophic slope failures. To date, early-warning has mostly relied on the availability of detailed, high-frequency data from sensors installed in situ. The same purpose could not be chased through spaceborne monitoring applications, as these could not yield information acquired in sufficiently systematic fashion. Here we present three sets of Sentinel-1 constellation images processed by means of multi-interferometric analysis. We detect clear trends of accelerating displacement prior to the catastrophic failure of three large slopes of very different nature: an open-pit mine slope, a natural rock slope in alpine terrain, and a tailings dam embankment. We determine that these events could have been located several days or weeks in advance. The results highlight that satellite InSAR may now be used to support decision making and enhance predictive ability for this type of hazard.
Towards scaling Twitter for digital epidemiology of birth defects
Authors: Klein Ari Z. , Sarker Abeed , Weissenbacher Davy , Gonzalez-Hernandez Graciela 
Published: October 2019

AbstractSocial media has recently been used to identify and study a small cohort of Twitter users whose pregnancies with birth defect outcomes—the leading cause of infant mortality—could be observed via their publicly available tweets. In this study, we exploit social media on a larger scale by developing natural language processing (NLP) methods to automatically detect, among thousands of users, a cohort of mothers reporting that their child has a birth defect. We used 22,999 annotated tweets to train and evaluate supervised machine learning algorithms—feature-engineered and deep learning-based classifiers—that automatically distinguish tweets referring to the user’s pregnancy outcome from tweets that merely mention birth defects. Because 90% of the tweets merely mention birth defects, we experimented with under-sampling and over-sampling approaches to address this class imbalance. An SVM classifier achieved the best performance for the two positive classes: an F1-score of 0.65 for the “defect” class and 0.51 for the “possible defect” class. We deployed the classifier on 20,457 unlabeled tweets that mention birth defects, which helped identify 542 additional users for potential inclusion in our cohort. Contributions of this study include (1) NLP methods for automatically detecting tweets by users reporting their birth defect outcomes, (2) findings that an SVM classifier can outperform a deep neural network-based classifier for highly imbalanced social media data, (3) evidence that automatic classification can be used to identify additional users for potential inclusion in our cohort, and (4) a publicly available corpus for training and evaluating supervised machine learning algorithms.
Stellar populations of galaxies in the ALHAMBRA survey up to z ∼ 1
Authors: Díaz-García L. A. , Cenarro A. J. , López-Sanjuan C. , Ferreras I. , Cerviño M. , Fernández-Soto A. , González Delgado R. M. , Márquez I. , Pović M. , San Roman I. , Viironen K. , Moles M. , Cristóbal-Hornillos D. , López-Comazzi A. , Alfaro E. , Aparicio-Villegas T. , Benítez N. , Broadhurst T. , Cabrera-Caño J. , Castander F. J. , Cepa J. , Husillos C. , Infante L. , Aguerri J. A. L. , Martínez V. J. , Masegosa J. , Molino A. , del Olmo A. , Perea J. , Prada F. , Quintana J. M. 
Published: September 2019

Aims.Our aim is to determine the distribution of stellar population parameters (extinction, age, metallicity, and star formation rates) of quiescent galaxies within the rest-frame stellar mass–colour diagrams andUVJcolour–colour diagrams corrected for extinction up toz ∼ 1. These novel diagrams reduce the contamination in samples of quiescent galaxies owing to dust-reddened galaxies, and they provide useful constraints on stellar population parameters only using rest-frame colours and/or stellar mass.Methods.We set constraints on the stellar population parameters of quiescent galaxies combining the ALHAMBRA multi-filter photo-spectra with our fitting code for spectral energy distribution, MUlti-Filter FITting (MUFFIT), making use of composite stellar population models based on two independent sets of simple stellar population (SSP) models. The extinction obtained by MUFFIT allowed us to remove dusty star-forming (DSF) galaxies from the sample of redUVJgalaxies. The distributions of stellar population parameters across these rest-frame diagrams are revealed after the dust correction and are fitted by LOESS, a bi-dimensional and locally weighted regression method, to reduce uncertainty effects.Results.Quiescent galaxy samples defined via classicalUVJdiagrams are typically contaminated by a ∼20% fraction of DSF galaxies. A significant part of the galaxies in the green valley are actually obscured star-forming galaxies (∼30–65%). Consequently, the transition of galaxies from the blue cloud to the red sequence, and hence the related mechanisms for quenching, seems to be much more efficient and faster than previously reported. The rest-frame stellar mass–colour andUVJcolour–colour diagrams are useful for constraining the age, metallicity, extinction, and star formation rate of quiescent galaxies by only their redshift, rest-frame colours, and/or stellar mass. Dust correction plays an important role in understanding how quiescent galaxies are distributed in these diagrams and is key to performing a pure selection of quiescent galaxies via intrinsic colours.
Aktuelle Behandlungsmethoden bei Verbrennungen der
Hände
Authors: Menke Henrik , Pierson Thomas , Parodi Corrado 
Published: October 2019

ZusammenfassungThermische Verletzungen im Bereich der Hände gehören zu den häufigsten
Verletzungen. Auch weisen die meisten Patienten mit ausgedehnten Verbrennungen
eine Beteiligung der Hände auf. Der Wiederherstellung dieser Körperregion kommt
aufgrund vielfältiger Aufgaben in Form, Funktion und Ästhetik eine herausragende
Bedeutung zu. Die dargestellten aktuellen Behandlungskonzepte der letzten Jahre
sind geprägt von einer Reduzierung der Invasivität, vermehrter Selektivität der
Nekrektomie und einer Förderung der natürlichen Regeneration mit
anatomiegerechter Rekonstruktion bzw. Restitution.
Objektive Tiefenbestimmung von Verbrennungen der
Hand
Authors: Promny Dominik , Billner Moritz , Reichert Bert 
Published: October 2019

ZusammenfassungDie Tiefenbestimmung einer thermischen Wunde unterliegt vielen Variablen und ist
nicht immer sicher vorzunehmen. Deshalb werden zunehmend technische Systeme zur
Bestimmung des Schweregrads eingesetzt. Besonders Verbrennungen im Bereich der
Hände können klinisch relevante Konsequenzen hinsichtlich des funktionalen
Ergebnisses und des ästhetischen Erscheinungsbilds haben, sodass gerade für
diese Areale eine sichere Einschätzung für eine adäquate Behandlung notwendig
ist.Technische Analysen wie das Hyperspectral-Imaging, Laser-Doppler-Imaging o. das
Laser-Speckle-Imaging sollen die Untersuchung vereinfachen und objektivieren,
indem sie dabei helfen, die notwendige Tiefe der Nekrosektomie zu bestimmen und
so das hauttransplantationspflichtige Areal zu reduzieren bzw. klarer zu
begrenzen. Zudem sollen sie so das funktionelle Ergebnis verbessern, die
Ausprägung von Vernarbungen und kosmetische Beschwerden verringern und die
Bewertung für in der Verbrennungsmedizin unerfahrenes Personal erleichtern.Dabei hat man unterschiedliche technische Ansätze verfolgt, die größtenteils auf
optischen Grundlagen basieren. Die jeweiligen Geräte werden bis dato noch nicht
in der Standarddiagnostik der Verbrennungswunden eingesetzt.In zukünftigen Studien gilt es einen Algorithmus für die Messintervalle aufgrund
der Wunddynamik zu ermitteln und zu evaluieren welche Methodik bzgl. der
jeweiligen Spezifität und Sensitivität überlegen ist.
Malnutrition in Paediatrics: Stationary Screening & Follow-up
Authors: Werner Dorothea , Zimmer Klaus-Peter , Eckert Gunter P. , Laffolie Jan de 
Published: October 2019

Abstract
Objective The prevalence and follow-up of the clinical real-world data focussing on existing or risk of malnutrition in a tertiary hospital general paediatric ward including 4 months of follow-up was assessed.
Methods Measurements included anthropometric measurements, a nutrition interview and an extended version of the Screening Tool for the Assessment of Malnutrition in Paediatrics (STAMP). R Studio 3.4.2 was used for statistical analysis and diagnosing malnutrition by calculating height-for-age (HfAz)-, weight-for-age (WfAz)- weight-for-height (WfHz)-, body mass index-for-age (BMIz) and mid-upper-arm circumference (MUACz)-z-scores with the childsds package with KIGGS and WHO for reference.
Results The median age of the 68 participants was 8.00 (4.00–13.00) years. The main reasons for hospitalisation in the tertiary centre were gastrointestinal diseases, diabetes mellitus and rheumatic diseases. At admission 39.71%, at the second examination 36.00% and at the third examination 45.90% were malnourished. 68% of inpatients lost weight during their clinical stay, of which 35.29% lost more than 3% of their initial weight. However, changes were not significantly different.
Conclusion A significant share of patients was diagnosed to be malnourished at admission, the majority of patients lost weight during their hospital stay and the 4 months after admission. Due to the far reaching consequences for patients, doctors, health insurance and politics, the early diagnosis and treatment of malnutrition should take greater account in the future.
Human Gaze Holding and Its Disorders
Authors: Shaikh Aasef G. 
Published: October 2019

AbstractStabilizing the retinal fovea on the object of interest is the most critical requirement for clear vision. Our brain implements sophisticated neural mechanisms to ensure stable gaze. In this article, I will review contemporary research delineating neural mechanisms for gaze holding. I will then describe various disorders of gaze holding in the context of basic neurophysiology, electrophysiology, and membrane biology. Particular focus is on the basic and translational neuroscience of central nystagmus of ocular motor and vestibular etiologies.
Dimethyl Sulfoxide Leads to Decreased Osteogenic Differentiation of Stem Cells Derived from Gingiva via Runx2 and Collagen I Expression
Authors: Lee Hyunjin , Park Jun-Beom 
Published: October 2019

Abstract
Objectives Dimethyl sulfoxide (DMSO) plays various functions, including cellular functions such as cellular growth. The aim of this study was to evaluate the effects of DMSO on the proliferation and osteogenic differentiation of human gingiva-derived stem cells.
Materials and Methods Stem cells derived from gingiva were cultured in the presence of DMSO at concentrations ranging from 0.01 to 10%.
Statistical Analysis We performed a one-way analysis of variance (ANOVA) with post hoc test to determine the differences between the groups using a commercially available program and the level of significance was 0.05.
Results The cells in the control group showed normal fibroblast morphology. The cells treated with 0.01%, 0.01%, 0.1%, and 1% DMSO were morphologically similar to those from the control group on each day. Statistically significant decreases in cell counting kit-8 (CCK-8) values were seen in the 3% and 10% DMSO groups (p < 0.05). A statistically significant decrease in alkaline phosphatase activity was seen in the 3% DMSO group. (p < 0.05). The application of DMSO produced a decrease in alizarin red S staining. The expression of Runx2 and collagen I by immunofluorescence decreased as the dose of lovastatin increased.
Conclusion The effects of DMSO on the viability of osteogenic differentiation among stem cells derived from human gingiva were evaluated. Applying DMSO produced decreased cell viability and decreased osteogenic differentiation in this experimental setting. This should be considered when designing and interpreting the data, and a DMSO-free method may be considered for bone regeneration applications.
Predictive Factors for Postoperative Outcome in Children with Jejunoileal Atresia
Authors: Jarkman Charlotta , Salö Martin 
Published: October 2019

Abstract
Background Jejunoileal atresia is a relatively rare congenital gastrointestinal requiring surgery and long postoperative care. The postoperative outcome is affected by many factors and this study focuses on finding predictors for time to full enteral feeding, length of hospital stay (LOH), and postoperative complications.
Methods This was a retrospective study of all children operated for isolated jejunoileal atresia between 2001 and 2017 at a tertiary center of pediatric surgery. Independent variables regarding demographical-, operative-, and postoperative data were abstracted. Primary outcome was time to full enteral feeding, LOH, and postoperative complications in terms of reoperation or central line complication. Any significant variables from the univariate analysis were further analyzed with logistic regression and presented as odds ratio with 95% confidence interval.
Results After exclusion because of concomitant gastroschisis (n = 1), and death before discharge (n = 2), 47 patients were further analyzed (49% boys, 53% premature). No significant differences could be seen in the univariate analysis between children with short and long time (median > 17 days) to full enteral nutrition. Patients with longer LOH (median >32 days) had significantly lower birth weight compared with those with shorter LOH; median 2,550 g versus 2,980 g (p = 0.04). Patients with a central line complication had significantly longer median time to full enteral feeding (median 27 vs. 12 days, p = 0.03), and significantly longer median LOH (median 43 vs. 21 days, p = 0.03), but these parameters were not significant in a multivariate analysis. No significant results were found regarding reoperation.
Conclusion Low birth weight seems associated with an increased LOH in children operated on for jejunoileal atresia, and central line complications seem related to the duration with central line in this group. The small cohort may constitute a power problem in this study and further research regarding the included variables may reveal more potential predictors for the postoperative outcome.
Chronischen Schmerz anders bewerten und empfinden
lernen
Authors: Otto Jan Carl 
Published: October 2019

ZusammenfassungPsychische und soziale Faktoren beeinflussen bei Patienten mit chronischen
unspezifischen Rückenschmerzen maßgeblich den Therapieverlauf und den
Behandlungserfolg. Gefragt sind empathische und kompetenzvermittelnde
Therapeuten, die bereits bei der Anamnese psychosoziale Aspekte erfassen und
ein multimodales Bahandlungskonzept aufstellen. Hierbei lernen
Patienten, ihre Erwartungshaltung zu reformieren, wodurch sie Schmerzen anders
bewerten und empfinden.
Apical Root Resorption: A Prospective Radiographic Study of Maxillary Incisors
Authors: Kocadereli Ilken , Yesil Turkan Nadire , Veske Pınar Sahin , Uysal Serdar 
Published: September 2019

ABSTRACTObjectives: The aim of this study was to determine the prevalence of apical root resorption in maxillary incisors during the initial stages of active orthodontic treatment and to test the hypothesis that root resorption increases with the progress of the treatment. Methods: The study sample consisted of 80 teeth of 20 patients (14 female, 6 male) with a mean age of 14.9±2.8 years. Root resorption was determined with standardized digitized periapical radiographs. All the periapical radiographs were obtained at the beginning of orthodontic treatment (T0) and 3 months (T1), 6 months (T2) and 9 months (T3) after the beginning of the treatment by a paralleling device. They were digitalized as 600 dpi with a flatbed scanner and analyzed by software for image analysis at 400x magnification utilizing a personal computer. Results: All of the 4 maxillary incisors had an increasing amount of resorption during the 9-month period. The amount of root resorption between the time intervals was statistically significant (P<.05). Conclusions: Root resorption of maxillary incisors can be detected in the early stages of orthodontic treatment and appears to be related to treatment duration. According to 9-month evaluation period, apical root resorption is of limited clinical significance for the average orthodontic patient. (Eur J Dent 2011;5:318-323)
Correlation between the Condyle Position and Intra-Extraarticular Clinical Findings of Temporomandibular Dysfunction
Authors: Sener Sevgi , Akgunlu Faruk 
Published: October 2019

ABSTRACTObjectives: To investigate the relationship between different clinical findings and condyle position. Methods: Tenderness on masseter (MM), temporal (TM), lateral pyterigoid (LPM), medial pyterigoid (MPM) and posterior cervical (PSM) muscles, limitation, deviation and deflection in opening of mouth, clicking, crepitating, tenderness on lateral palpation of temporomandibular joint (TMJ) area for each side of 85 patients were evaluated. Each side of patients was categorized into the clinical findings: no sign and/or symptom of temporomandibular dysfunctions (TMDs), only extraarticular findings and only intraarticular findings, extra and intraarticular findings. Condyle positions of 170 TMJs were determined the narrowest anterior (a) and posterior interarticular distance (p) on midsagittal MRIs of condyles and expressed as p/a ratio and these ratio were transformed into logarithmic base e. Spearman’s Correlation was used to investigate the relationship between the condyle position and the clinical findings. The difference between the condyle positions of different groups was tested by T test. Reliability statistic was used to determine intra-observer concordance of two measurements of condylar position. Results: A significant relationship was found between the condyle position and tenderness of PSM. There was no significant difference between the groups in aspect of the condyle position. Occlusion and condyle position correlated with significantly. Conclusions: The inclination of the upper cervical spine and craniocervical angulations can cause the signs and symptoms of TMD and condyle position is not main cause of TMDs alone but it may be effective together with other possible etiological factors synergistically. (Eur J Dent 2011;5:354-360)
Evaluation of surface roughness and hardness of different glass ionomer cements
Authors: Bala Oya , Arisu Deniz Hacer , Yikilgan Ihsan , Arslan Seda , Gullu Abdulkadir 
Published: September 2019

ABSTRACTObjectives: The aim of this study was to evaluate surface roughness and hardness of a nanofiller GIC, a resin-modified GIC, three conventional GICs, and a silver-reinforced GICMethods: For each material, 11 specimens were prepared and then stored in distilled water at 37 °C for 24 h. The surface roughness of 5 specimens was measured using a surface profilometer before polishing and after polishing with coarse, medium, fine, superfine aluminum oxide abrasive Sof-Lex discs respectively. The hardness of the upper surfaces of the remaining 6 specimens was measured with a Vickers microhardness measuring instrument.Results: All tested GICs showed lower surface roughness values after the polishing procedure. Surface finish of nanofiller GIC was smoother than the other tested GICs after polishing. This was followed by resin-modified GIC, Fuji II LC; then silver-reinforced GIC, Argion Molar, conventional GICs, Aqua Ionofil Plus, Fuji IX, and Ionofil Molar, respectively. The result of the hardness test indicated that the microhardness value of silver-reinforced GIC was greater than that of the other GICs. When the hardness values of all tested GICs were compared, the differences between materials (except Aqua Ionofil Plus with Ionofil Molar and Ketac N100 with Fuji II LC (P>.05)) were found statistically significant (P<.05).Conclusions: According to the results of this study, it can be concluded that the differences in the
composition of GICs may affect their surface roughness and hardness. (Eur J Dent 2012;6:79-86)