bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Spirit of Pentecost and the Future of Creation
Authors: Augustine Daniela C. 
Published: October 2024

Abstract
Studebaker’s overarching thesis is that “the Holy Spirit is the telos of redemption and, therefore, the divine person that consummates the fellowship of the triune God.” This thesis reflects not only the trajectory of current pentecostal scholarship, but the very core of Eastern Orthodox pneumatology that has primed the theological imagination and sacramental life of many Eastern European Pentecostals. This present reflection highlights a few questions that invite further engagement and offers a brief contemplation on three related subthemes within the proposal, pointing to some helpful insights from the Orthodox tradition. These subthemes are the event of Pentecost as the theotic telos of creation; the Spirit and the resurrection; and the redemptive significance of Spirit baptism (focusing on the pentecostal experience of glossolalia and xenolalia).
Catching Up with the Future: Diplomacy for a New Global Landscape
Authors: Uilenreef Arjan 
Published: October 2024

Summary
This contribution discusses the impact of three structural phenomena on the strategic functions of future diplomacy. The first is the shifting global power balance, which has important consequences for the manner in which European ministries of foreign affairs reposition themselves with regard to both big and middle powers. The assertiveness of big, revisionist states implies a return to realpolitik in which hard power takes centre stage. The ascendency of middle powers reinforces the need to build equal partnerships with increasingly influential non-Western countries. The other two game changers are the existential challenges of climate change and the ascent of artificial intelligence. A conflict-sensitive climate approach requires an adjusted diplomatic toolkit. Artificial intelligence has an effect on many different policy dimensions, from international governance to trade promotion. All these developments are relevant to the practice of diplomacy and the skills diplomats need in order to navigate through a changing global environment.
‘Vaping is a break from all of that’: Exploring attitudes, harm perceptions, cessation barriers and social dynamics among people who vape
Authors: Piatkowski Timothy , Clarke Cheya , Puljević Cheneal , Caudwell Kim M 
Published: October 2024

Objective: Vaping, initially a smoking cessation aid, is now a widespread recreational activity sometimes associated with perceived health concerns. This study explored attitudes, harm perceptions and cessation barriers in the context of participants’ vaping behaviours, guided by the theoretical lens of fundamental social causes. Design and Setting: The study focused on a subset of 571 current adult vapers from a larger survey investigating vaping attitudes. It analysed open-text survey responses relating to vaping behaviours. To analyse the responses, we employed layered analyses, using deductive conceptual mapping to inform an inductive thematic content analysis. Results: Participants mentioned nuanced vaping risks, citing cancer and respiratory concerns, often comparing them to tobacco’s well-known harmful effects. Despite acknowledging vaping’s potential harms, participants perceived the practice to be less harmful than smoking, emphasising relative safety. Some viewed vaping positively for former smokers, contingent on regulated products. This complex attitude balance reflected the intricate interplay between health concerns and social dynamics. Recurrent vaping symbolised consistent engagement, with cravings and widespread availability associated with quitting challenges. Conclusions: Participants’ nuanced perceptions of health risks reflect a harm duopoly, resembling illicit drug harm tiering. There is a complex interplay between health knowledge and social influences in the context of vaping behaviours. Study findings underscore the need for messaging interventions discouraging vaping among those who do not smoke tobacco to consider these health and social dynamics, leveraging collaborative design.
Exercise intensity and mortality in overweight and obese patients with chronic kidney disease: longitudinal analysis (1999–2016)
Authors: Qian Chuyue , Zhou Fengjun , Lu Dandan , Huang Jingda , Sun Mindan 
Published: October 2024

Abstract
Background
Chronic kidney disease (CKD) and overweight/obesity are significant global public health issues. Appropriate free-time physical activity (PA) is essential for overweight/obese patients with chronic kidney disease, but specific guidelines are lacking. The present study was conducted to determine the association between PA and all-cause mortality in these patients.

Methods
Data from 3,434 overweight/obese adults with CKD from the 1999–2016 National Health and Nutrition Examination Surveys were analyzed. Associations between clinical/laboratory findings and PA intensity (moderate and vigorous) were investigated. The all-cause mortality of patients in different PA categories were compared by Kaplan–Meier analysis. Factors associated with all-cause mortality were determined using a Cox proportional hazards model. A restricted cubic spline was employed to obtain a more flexible and detailed representation of the relationship between PA intensity and all-cause mortality, with better predictive capability.

Results
The Kaplan–Meier analysis revealed that greater all-cause mortality was associated with < 10 min/week moderate/vigorous PA (log-rank p < 0.001). A greater survival probability was associated with ≥ 150 min/week vigorous PA or 10–149 min/week moderate PA (log-rank p < 0.001). Age, gender, vigorous PA, smoking status, alcohol consumption, diabetes status, eGFR, serum albumin level, uric acid level, and blood urea nitrogen level were identified as factors associated independently with mortality in the Cox proportional hazards analysis. The restricted cubic splines revealed that these relationships were non-linear (all p < 0.05). Kaplan–Meier analysis of data from patients who engaged in 10–450 min/week moderate/vigorous PA revealed significant differences between the 0–74-min/week and other vigorous PA groups (all log-rank p < 0.001).

Conclusions
Extended durations of vigorous PA are associated with reduced all-cause mortality in overweight/obese patients with CKD. Clinicians should recommend vigorous free-time PA to these patients, and public health interventions should target this goal to maximize patient health.
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Authors: Walker Keenan A. , An Yang , Moghekar Abhay , Moaddel Ruin , Duggan Michael R. , Peng Zhongsheng , Tian Qu , Pilling Luke C. , Drouin Shannon M. , Espeland Mark A. , Rapp Stephen R , Hayden Kathleen M , Shadyab Aladdin H. , Casanova Ramon , Thambisetty Madhav , Rapp Peter R. , Kapogiannis Dimitrios , Ferrucci Luigi , Resnick Susan M. 
Published: October 2024

Abstract
Background
Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease (AD). This case-cohort study used targeted plasma biomarkers and large-scale proteomics to examine the biological mechanisms that allow some APOEε4 carriers to maintain normal cognitive functioning in older adulthood.

Methods
APOEε4 carriers and APOEε3 homozygotes enrolled in the Women’s Health Initiative Memory Study (WHIMS) from 1996 to 1999 were classified as resilient if they remained cognitively unimpaired beyond age 80, and as non-resilient if they developed cognitive impairment before or at age 80. AD pathology (Aß42/40) and neurodegeneration (NfL, tau) biomarkers, as well as 1007 proteins (Olink) were quantified in blood collected at study enrollment (on average 14 years prior) when participants were cognitively normal. We identified plasma proteins that distinguished between resilient and non-resilient APOEε4 carriers, examined whether these associations generalized to APOEε3 homozygotes, and replicated these findings in the UK Biobank.

Results
A total of 1610 participants were included (baseline age: 71.3 [3.8 SD] years; all White; 42% APOEε4 carriers). Compared to resilient APOEε4 carriers, non-resilient APOEε4 carriers had lower Aß42/40/tau ratio and greater NfL at baseline. Proteomic analyses identified four proteins differentially expressed between resilient and non-resilient APOEε4 carriers at an FDR-corrected P < 0.05. While one of the candidate proteins, a marker of neuronal injury (NfL), also distinguished resilient from non-resilient APOEε3 homozygotes, the other three proteins, known to be involved in lipid metabolism (ANGPTL4) and immune signaling (PTX3, NCR1), only predicted resilient vs. non-resilient status among APOEε4 carriers (protein*genotype interaction-P < 0.05). Three of these four proteins also predicted 14-year dementia risk among APOEε4 carriers in the UK Biobank validation sample (N = 9420). While the candidate proteins showed little to no association with targeted biomarkers of AD pathology, protein network and enrichment analyses suggested that natural killer (NK) cell and T lymphocyte signaling (via PKC-θ) distinguished resilient from non-resilient APOEε4 carriers.

Conclusions
We identified and replicated a plasma proteomic signature associated with cognitive resilience among APOEε4 carriers. These proteins implicate specific immune processes in the preservation of cognitive status despite elevated genetic risk for AD. Future studies in diverse cohorts will be needed to assess the generalizability of these results.
Astaxanthin improves assisted reproductive technology outcomes in poor ovarian responders through alleviating oxidative stress, inflammation, and apoptosis: a randomized clinical trial
Authors: Shafie Anahid , Aleyasin Ashraf , Saffari Mojtaba , Saedi Mojtaba , Rostami Sahar , Rezayi Saeede , Mohammadi Seyed Danial , Amidi Fardin 
Published: October 2024

Abstract
Background
Poor ovarian response (POR) to controlled ovarian stimulation (COS) remains challenging, especially in advanced-age women with diminished ovarian reserve, resulting in low live birth rates. Many patients prefer to conceive with their eggs, underscoring the need for improved treatments. This study explores astaxanthin potential as a COS adjuvant to improve ovarian response and assisted reproductive technology (ART) outcomes, considering its impact on oxidative stress (OS), inflammation, and apoptosis, which are key factors in POR.

Methods
In this randomized, triple-blind, placebo-controlled trial, 60 infertile POR patients from POSEIDON Group 4 (the poorest prognosis category, age > 35 and poor ovarian reserve (anti-müllerian hormone < 1.2 ng/ml or antral follicle count < 5) undergoing intracytoplasmic sperm injection were enrolled. Patients were assigned to receive either 12 mg/day AST or placebo for eight weeks. All patients underwent a gonadotropin-releasing hormone antagonist regimen for COS. ART outcomes were compared between groups. Blood serum and follicular fluid (FF) were analyzed for OS markers (superoxide dismutase [SOD], total antioxidant capacity [TAC], and malondialdehyde [MDA]), and pro-inflammatory cytokines (interleukin-6 [IL-6], interleukin-8 [IL-8], and vascular endothelial growth factor [VEGF]) via enzyme-linked immunosorbent assay kits, and cell-free DNA [cfDNA] (apoptotic marker) via ALU quantitative polymerase chain reaction.

Results
After the intervention, the AST group exhibited a significant elevation in serum (P = 0.013) and TAC (P = 0.030), accompanied by a significant reduction in serum MDA (P = 0.005). No significant differences between AST and placebo groups were observed in OS markers in FF. AST group showed significant reductions in the serum IL-6 (P < 0.001), IL-8 (P = 0.001), and VEGF (P = 0.002) levels following AST therapy. In the AST group, FF levels of IL-6 (P = 0 < 001), IL-8 (P = 0.036), VEGF (P = 0.006), and cfDNA (P < 0.001) were significantly lower than in the placebo group. Between-group comparisons showed significant differences in the alterations of serum SOD (P = 0.027), IL-6 (P < 0.001), and IL-8 (P = 0.035) levels between AST and placebo groups. The AST group showed significant increases in the number of retrieved oocytes (P = 0.003), MII oocytes (P = 0.004), frozen embryos (P = 0.037), and high-quality embryos (P = 0.014) compared to the placebo group.

Conclusion
AST shows promise as a COS adjuvant therapy, potentially enhancing some ART outcomes in POR through alleviating OS, inflammation, and apoptosis.

Trial registration
Clinical trial registration number: IRCT20230223057510N1, URL: https://irct.behdasht.gov.ir/trial/68870, registration date: 2023 March 16.

Graphical Abstract
SPARC activates p38γ signaling to promote PFKFB3 protein stabilization and contributes to keloid fibroblast glycolysis
Authors: Liu Yining , Zhang Wei , Lin Nan , Yang Zelei , Liu Yanxin , Chen Huaxia 
Published: October 2024

Abstract
Background
Keloids are currently challenging to treat because they recur after resection which may affect patients’ quality of life. At present, no universal consensus on treatment regimen has been established. Thus, finding new molecular mechanisms underlying keloid formation is imminent. This study aimed to explore the function of secreted protein acidic and cysteine rich (SPARC) on keloids and its behind exact mechanisms.

Methods
The expression of SPARC, p38γ, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), α-SMA, and Ki67 in patients with keloid and bleomycin (BLM)-induced fibrosis mice was assessed utilizing western blot, qRT-PCR, and immunohistochemical staining. After transfected with pcDNA-SPARC, si-SPARC-1#, si-SPARC-2#, and si-p38γ, and treated with glycolytic inhibitor (2-DG) or p38 inhibitor (SB203580), CCK-8, EdU, transwell, and western blot were utilized for assessing the proliferation, migration, and collagen production of keloid fibroblasts (KFs).

Results
SPARC, p38γ, and PFKFB3 were highly expressed in patients with keloid and BLM-induced fibrosis mice. SPARC promoted the proliferation, migration, and collagen production of KFs via inducing glycolysis. Moreover, SPARC could activate p38γ signaling to stabilize PFKFB3 protein expression in KFs. Next, we demonstrated that SPARC promoted the proliferation, migration, collagen production, and glycolysis of KFs via regulating p38γ signaling. In addition, in BLM-induced fibrosis mice, inhibition of p38γ and PFKFB3 relieved skin fibrosis.

Conclusions
Our findings indicated that SPARC could activate p38γ pathway to stabilize the expression of PFKFB3, and thus promote the glycolysis of KFs and the progression of keloid.
Outcomes of patients with COVID-19 pneumonia requiring lung resections in a third-level hospital
Authors: Sánchez-Pereda Diego , Gomez-Portugal Emmanuel Peña , Canto-Losa Jorge , Jaspersen-Álvarez Jorge , Anaya-Ayala Javier E. 
Published: October 2024

Abstract
Introduction
Currently, there is little evidence on the surgical management of pulmonary complications of COVID-19 pneumonia. This study aimed to give insight into common complications arising in patients with COVID-19 pneumonia that require lung resections.

Methods
This is a retrospective single-center study looking at conditions arising in patients with COVID-19 pneumonia who required lung resection for resolution between March 2020 and March 2021. Clinical presentation, indications to undergo surgery, and factors associated with increased mortality were analyzed. Analysis of nominal variables was performed using nonparametric statistical tests.

Results
Twelve men (92.3%) and one woman (7.7%) were included in the analysis; the age of included participants ranged from 27 to 72 years, with the mean age being 52. The most common presenting signs and symptoms were dyspnea and tachypnea, which were present in all patients, most common cause for surgery was pneumatocele with 6 cases, followed by lung abscess; patients who underwent surgery because of persistent air leak were more likely to require surgical reintervention (p = 0.005). The overall mortality in our sample was 23%. Increasing age (p = 0.014), myalgias (p = 0.035), elevated D-dimer (p = 0.007), and pulmonary embolism (p = 0.014) were associated with increased mortality.

Conclusions
Lung resections to treat pulmonary complications in patients with COVID-19 pneumonia appear to be safe, with a survival rate of 77%. Recognizing clinical characteristics such as age, myalgias, elevated D-dimer and pulmonary embolism can aid in identifying those at increased risk.
Visual colorimetric immunosensor for sensitive detection of 4-Chlorophenoxyacetic based on TMB2+-mediated etching of Au NRs
Authors: Han Jinzhi , Peng Cheng , Wen Jiayan , Cao Xueming , Wang Yu , Meng Jingnan , Xu Zhenlin 
Published: October 2024

Abstract4-Chlorophenoxyacetic acid (4-CPA), a synthetic plant regulator, has been banned due to its cumulative toxicity to humans. However, unqualified sampling remains common in the market. To address the poor sensitivity of 4-CPA antibodies reported previously, a highly sensitive monoclonal antibody specific to 4-CPA was produced by redesigning and synthesizing a novel hapten in this study. Additionally, a visual colorimetric immunosensor based on TMB2+ mediated etching of gold nanorods (Au NRs) was developed. The ∆λ of the localized surface plasmon resonance (LSPR) peak exhibited a linear dependence on the 4-CPA concentration in the range of 0.2–6.25 ng mL−1, with a low limit of detection (LOD) of 0.2 ng mL−1. Recovery tests (85.0% to 108%) and HPLC validation demonstrated the immunosensor’s accuracy and precision. This visual colorimetric immunosensor illustrates significant potential for rapid detection of 4-CPA in biological environments.
Temporal and regional trends in Canada for the epidemiology and management of diabetic foot ulcers
Authors: Park Ye-Jean , Ma Bryan , Jia Jocelyn , Parsons Laurie 
Published: October 2024

Objective: Diabetic foot ulcers (DFUs) are a common downstream consequence of diabetes and pose significant concern to the health of affected individuals. There are currently limited data available that detail the epidemiology and inpatient burden of DFUs in Canada. This study aims to provide updated data on the epidemiological and economic burden of DFUs in Canada between 2015 and 2019. Method: Using the Canadian Institute for Health Information Patient Cost Estimator the authors estimated, as the primary outcome, the number of DFU inpatient cases in Canada, the associated financial burden of these admissions on the Canadian healthcare system, physician compensation, and average patient length of hospitalisation. This analysis covered 12 Canadian jurisdictions and was stratified by age, sex, province and geographical region. The secondary outcome was to highlight temporal trends in the public health burden of DFUs by computing the average annual percentage change (AAPC; the weighted average of several annual percentage changes over multiple years) using Joinpoint (Surveillance Research Program National Cancer Institute, US) regression analysis. Results: The total number of cases, average length of hospitalisation and physician costs across Canada were highest for patients over ≥60 years of age. By region, the total number of cases and standardised physician costs were highest in Central Canada, followed by Western Canada, and subsequently Eastern and Northern Canada. In 2019, there were >1800 patients with DFUs admitted to Canadian acute care hospitals. Despite having the lowest number of inpatient admissions, Northern Canada had the highest associated inpatient costs, followed by Central, then Western and, lastly, Eastern Canada. Overall, mean inpatient costs remained stable over time across all age groups (AAPC 0.61; 95% confidence interval: –1.87–3.15), with an average cost of >$10,000 CAD per case. Average physician cost across all jurisdictions was approximately $1000 CAD per case, with the mean hospitalisation time being nine days. Conclusion: The findings of this study emphasise the dynamic nature of the economic and epidemiological DFU burden in Canada, underscoring the need for targeted interventions, multidisciplinary care and evidence-based resource allocation for the optimal management of diabetes and DFUs.
A dedicated wound care module for third-year baccalaureate nurses: does it increase their knowledge and confidence?
Authors: Parker Christina N , Finlayson Kathleen , Johnston Sandra 
Published: October 2024

Objective: Wound care is an important component of nursing care, consuming a significant amount of working hours. Literature reports the existence of many barriers to evidence-based wound care and that nursing students have an increasing need for education in this field. While blended learning activities have shown some benefits in learning outcomes, dedicated wound care modules within baccalaureate nursing courses occur infrequently. The aim of this study was to facilitate an increase in confidence and knowledge of evidence-based wound care in third-year baccalaureate nursing students. Method: In this descriptive pre–post research design, a dedicated wound care module within a baccalaureate nursing course (using a constructivist learning approach) was offered to students in a university in Australia. Pre- and post-implementation surveys were completed (2018–2020). Due to a small number of matching participants, only descriptive statistics were calculated for all variables. Results: A total of 276 students were invited to respond to the survey and 41 responded initially, 35 responded post the wound care module, and 26 responded to the survey after six months. Positive outcomes were noted in increased levels of confidence in the student nurses’ ability to assess, manage and prevent wounds; as well as to apply evidence-based practice and change management following the educational wound care module within the baccalaureate nursing course. Conclusion: Implementation of a dedicated wound care module within a baccalaureate nursing course in this sample of third-year students fostered a positive change in the knowledge of evidence-based wound management, assessment and prevention. Education of the next generation of registered nurses in this valuable area of practice is an important part of baccalaureate nursing education.