bluuebunny/crossref_metadata_2025_split huggingface dataset:
Classifying Climate‐Suitable Lands in California for Coffee Cultivation
Authors: Prewitt Kenneth B. , Abatzoglou John T. , Viers Joshua H. , Naughton Colleen C. 
Published: December 2024

ABSTRACTIncreased market for specialty coffee and climate volatility in traditional coffee‐growing regions of the world has prompted interest in cultivating coffee outside of the tropics, including in California. While several small coffee farms have established in California over the past couple decade, no studies have identified and quantified climatically suitable regions for growing coffee. We developed a model of Coffea arabica suitability based on agronomic studies of thermal constraints to coffee cultivation, combining heat and cold intolerance with energy requirements for maturation. This model was applied to agricultural lands across California using high‐resolution climate datasets for both modern (1991–2020) and projected near‐term (2021–2050) conditions. We explored the potential for farm thermal management approaches—such as using agroforestry shade trees—to buffer temperature extremes and augment thermal suitability. Results indicate that, in the absence of thermal management approaches, nearly all agricultural lands in the state experience temperature extremes detrimental to coffee cultivation in modern climate. By contrast, we found that over 230 km2 of agricultural land in coastal southern and central California is thermally suitable for coffee with management efforts. These suitable areas include most of the state's avocado cultivation—which may serve as a thermal buffer for coffee and favour the environmental and economic agricultural sustainability of this coupled crop system. We additionally show that projected near‐term climate coupled with management efforts leads to moderate increases in thermally suitable agricultural lands for coffee cultivation. Despite numerous economic and logistical challenges, that impede the growth of a burgeoning coffee region in coastal, southern and central California, we demonstrate that climate conditions in both today and in the future, combined with agronomic management efforts such as shading, provide an opportunity for a viable coffee production in California.
Cropland Exposure to Extreme Dryness and Wetness in China Under Shared Socioeconomic Pathways
Authors: Yang Ruiting , Wang Guojie , Zhang Yunxia , Zhang Peng , Li Shijie , Cabral Pedro 
Published: December 2024

ABSTRACTGlobal warming by human activities have exacerbated the occurrence of extreme climatic events, which have taken a huge toll on human production and livelihoods. Predicting future changes in extreme wetness and dryness, along with the extent of cropland exposure to these conditions under various scenarios, is essential for effective climate adaptation and achieving sustainable development goals. This study employs the Standardised Antecedent Precipitation Evapotranspiration Index (SAPEI) method to identify extreme dryness and extreme wetness in China for future projections (2021–2100), and to analyse the characteristics of changes in the pixel‐day, intensity, and affected area by extreme dryness and wetness, as well as the cropland exposures to them under different shared socioeconomic pathways (SSPs). We find that the intensity and spatial extent of extreme dryness and wetness significantly increase in future climate projections, especially under high‐emission scenario compared to low‐emission scenario. Under the scenarios with increased emissions, the cropland exposure increased in most parts of China. Therefore, it is particularly urgent to keep the low‐emission scenario in order to minimise the cropland damage caused by extreme drought and wetness in China in the future.
Evaluating the use of glucagon‐like peptide‐1 receptor agonists in a matched cohort of kidney and liver transplant recipients
Authors: Baik Isabel , Jantz Arin , Poparad‐Stezar Adina , Venkat Deepak , Khoury Nadeen , Samaniego‐Picota Milagros , Gonzalez Humberto C. , Fitzmaurice Mary Grace 
Published: December 2024

AbstractBackgroundDiabetes mellitus (DM) and obesity are common among solid organ transplant recipients, but are associated with an increased risk of graft failure.AimAlthough glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are effective for managing both conditions in the general population, there is limited evidence regarding their use among transplant recipients.MethodThe effect of GLP‐1 RAs on post‐transplant glucose control (defined as haemoglobin A1c [HbA1c]) among 37 liver and kidney transplant patients was compared to a control cohort. Secondary outcomes included change in total daily insulin requirements and oral DM agents, estimated glomerular filtration rate (eGFR), weight, and body mass index (BMI). Adverse events attributed to GLP‐1 RAs, hypoglycaemia, incidence of pancreatitis, biopsy‐proven acute rejection, graft loss, and death were assessed. Ethical approval was granted by the Henry Ford Health Institutional Review Board (Reference no: 15959) and the study conforms with the US Federal Policy for the Protection of Human Subjects.ResultsWe observed that patients receiving GLP‐1 RAs had a median reduction in HbA1c of 0.5% and reduction in insulin and oral anti‐DM agents compared to the control group without GLP‐1 RAs. There were statistically significant reductions in both weight and BMI in the GLP‐1 RA group. Our observed incidence of adverse events was similar to previous literature. Unlike other smaller studies, a decline in eGFR was observed in the GLP‐1 RA group. There were no differences in incidence of biopsy‐proven acute rejection, graft loss, or death.ConclusionWhen compared to patients without GLP‐1 RA therapy, GLP‐1 RAs modestly reduced HbA1c and insulin requirements and statistically reduced weight/BMI review at 6 months. GLP‐1 RAs, even if initiated early post‐transplant, were seemingly safe and effective. Larger, prospective studies are warranted to evaluate the safety and efficacy of GLP‐1 RAs in this population.
Buforins: A Potential Antimicrobial Peptide Explored With Its Anticancer Efficacy‐A Review
Authors: Adhikari Surya Narayan Ratha , Jena Jitendra , Kar Sanjeeb Kumar , Singh Alka , Panigrahi Biman Kumar , Sarangi Manoj Kumar 
Published: December 2024

ABSTRACTAntimicrobial peptides (AMPs), derived from numerous life forms, is being recognised as favourable contenders in today's era to overcome the multi drug resistance of cancer cells. Despite of their diverse structural orientations (β‐sheet, α‐helical, loop and extended peptides), they are immensely involved in immune defences and potentially involved for combating cancers and other types of infections via cellular membrane depolarization. Buforins (Bf), the histone H2A derived AMPs along with their analogues (like Bf‐I, Bf‐II and Bf‐IIb) demonstrated substantial anticancer efficacy despite of numerous challenges. They are quite effective in controlling the apoptosis in various cancer cell lines like breast, HeLa, ovarian, lung, liver and prostate cancers. Bf conjugated with bioconjugates were explored for enhancing the bioavailability, drug resistance and stability of these super giants in cancer therapy. The functionalized nanoparticles could possibly help to overwhelm the shortcomings of AMPs, towards cancer therapy. However, the success of in vivo approach may lead to the clinical translation of such therapeutics. In this review, we emphasized on the characteristic features, mechanisms of action, numerous anticancer approaches of Bf. Further discussion was continued with the challenges and their overcoming, advancement and future directions of Bf towards their success in chemotherapy.
Pharmacokinetics of cefiderocol in a patient with carbapenem‐resistant Acinetobacter baumannii ventriculitis: A case report
Authors: Finch Natalie A. , Granillo Alejandro , Pouya Nazanin , Bhimraj Adarsh , Miller William R. , Tam Vincent H. 
Published: December 2024

AbstractObjectiveCefiderocol is a novel antibiotic used to treat multidrug‐resistant bacterial infections. However, there is limited data on its effectiveness for ventriculitis. The objective of this study was to evaluate cefiderocol concentrations in both serum and cerebrospinal fluid (CSF) during the treatment of ventriculitis.MethodA 54‐year‐old patient with carbapenem‐resistant Acinetobacter baumannii ventriculitis was given cefiderocol intravenously 2 g every 6 h (each dose administered over 3 h). Serial samples were obtained over a dosing interval at steady state, and cefiderocol concentrations in serum and CSF were assayed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Cefiderocol serum concentration‐time profile was characterized by a one‐compartment model with zero‐order input. Penetration into CSF was estimated as the CSF AUC/unbound serum AUC ratio.ResultsObserved total serum concentrations ranged between 24.6 and 76.7 mg/L, while CSF concentrations were approximately 10.0 mg/L. The AUC0–6 of the free drug in serum and CSF were 181.6 and 60.2 mg h/L, respectively.ConclusionWe observed minimal fluctuation of cefiderocol concentrations in CSF, questioning the conventional reliance on CSF/serum area under the curve (AUC) ratio as a measure of CNS penetration. Our experience suggests that a single CSF concentration (random or trough) could be directly compared to the minimum inhibitory concentration, offering a potentially simpler approach to evaluate dosing adequacy.
LncRNA C7orf13 facilitates cell proliferation and metastasis in nasopharyngeal carcinoma via targeting miR‐449c/miR‐28‐5p‐FMNL2 axis
Authors: Xie Peng , Zhang Yujie , Shang Jin , Yu Hanxu , Du Mingyu , Shu Jian , Wei Qiang , Zhu Zeyu , He Xia 
Published: December 2024

AbstractThis study was to determine the involvement of long non‐coding RNA C7orf13 in nasopharyngeal carcinoma (NPC) and its underlying mechanism. Real‐time quantitative PCR results indicated that C7orf13 was overexpressed in NPC and associated with malignant features. C7orf13 knockdown significantly suppressed the proliferation, migration and invasion of NPC cells. Furthermore, we found that C7orf13 sequestered miR‐449c and miR‐28‐5p in NPC cells by dual‐luciferase reporter assays and RNA immunoprecipitation analysis. Sequent experiments showed that C7orf13 has a positive relationship with formin‐like 2 (FMNL2) in NPC tissues. Moreover, C7orf13 knockdown weakened FMNL2‐mediated cell invasion and migration. Finally, functional experiments revealed that the positive effect of C7orf13 on cell migration and invasion was mediated by the miR‐449c/miR‐28‐5p‐FMNL2 axis. Generally, our study identifies the biological role of long non‐coding RNA C7orf13 in the malignant process of NPC, which may pave a new way for the diagnosis and treatment of NPC.
Design, synthesis, X‐ray crystal structure, and antifungal evaluation of new acetohydrazide derivatives containing a 4‐thioquinazoline moiety
Authors: Tian Guang‐Min , Yi Ming‐Yan , Yan Tai‐Sen , Liu Song‐Song , Huang Jian , Li Hong , Bao Xiao‐Ping 
Published: December 2024

AbstractBACKGROUNDTo find efficient agricultural fungicides, 29 new 4‐thioquinazoline‐containing acetohydrazide derivatives were prepared and tested for their fungicidal properties.RESULTSAll of the target compounds were characterized by 1H and 13C nuclear magnetic resonance and high‐resolution mass spectrometry techniques, and the molecular structure of compound A2 was verified by single‐crystal X‐ray diffraction measurement. The experimental results revealed that many compounds from this series had impressive inhibition efficacies in vitro against the tested fungi. For example, compound A25 was identified as the best fungicidal agent against Rhizoctonia solani with an EC50 (half‐maximal effective concentration) value of 0.66 μg mL−1, superior to those of the commercial fungicides chlorothalonil, carbendazim and boscalid. Additionally, this compound displayed favorable protection and curative activities in vivo against rice sheath blight caused by R. solani. Antifungal mechanistic studies on compound A25 indicated that this compound exerted its strong anti‐R. solani effects probably through an effective inhibition of fungal succinate dehydrogenase activity [half‐maximal inhibitory concentration (IC50) = 4.88 μm] and the impairment of cell membrane integrity, based on the results from enzymatic bioassays, molecular docking studies, and scanning and transmission electron microscopy observations.CONCLUSIONAcetohydrazide derivatives containing the 4‐thioquinazoline moiety had the potential to be employed as lead compounds for developing more efficient agricultural fungicides in the near future. © 2024 Society of Chemical Industry.
Strong temperature falls as a cold frontal metric in Australian station observations, reanalyses and climate models
Authors: King Malcolm J. , Reeder Michael J. , Jakob Christian 
Published: December 2024

AbstractCold fronts are an important component of subtropical and midlatitude weather systems. While a range of objective front detection methods exist, these methods are only applicable to gridded data and generally require smoothing and threshold parameter changes with differing spatial resolution in order to obtain similar results. This precludes analyses using these methods from using point‐location data (such as station observations) or comparing datasets with different spatial resolutions. We present a method using daily maximum temperature changes as a way of identifying strong, dry cold fronts (that is, fronts without much associated rainfall) across a range of datasets. Frontal zones identified using this method are well correlated with cold‐front locations using an objective front scheme, and results do not change significantly as data resolution changes over the range from 0.25 to 2.25°. The method is applied to generate front climatologies in 41 global climate models from phase 6 of the Coupled Model Intercomparison Project (CMIP6), showing these models overestimate the number of cold fronts in polar regions relative to the number over midlatitude land regions, and that there is a large intermodel spread in front occurrence. The method is also applied to southern Australian stations, showing that there are minimal trends in front occurrence for longer running stations, although an increase in front occurrence since 1950 is seen in the southeast of Australia. Interannual variability in strong front occurrence is connected to the state of both El Niño Southern Oscillation (ENSO) and the Southern Annular Mode (SAM), with El Niño and negative SAM conditions both seeing increases in the occurrence of strong cold fronts in southeastern Australia.
Phylogenetics and morphological character evolution in the achyranthoid clade (Amaranthaceae): Evidence to re‐circumscribe the genera Achyranthes and Cyathula and to resurrect a third species of the former genus Sericocomopsis in East Africa
Authors: Di Vincenzo Vanessa , Berendsohn Walter , Wondafrash Melaku , Borsch Thomas 
Published: December 2024

AbstractThe achyranthoid clade constitutes the second most species‐rich lineage of the Amaranthaceae after the gomphrenoid clade. The Achyranthoids are mostly African, in contrast to the largely Neotropical Gomphrenoids, and comprise a large number of genera, many of which were revealed as non‐monophyletic. Here were focus on subclade II of the Achyranthoids with the so far accepted genera Achyranthes, Achyropsis, Centrostachys, Cyathula, Nelsia, Nototrichium, Pandiaka, Sericocomopsis, and Sericostachys. Building upon an earlier dataset, we extended taxon and character sampling, both for molecular and morphological characters. Our plastid and nuclear trees converge on several highly supported clades, one comprising most species of Cyathula, Nelsia, Pandiaka and two highly divergent lineages of plants hitherto identified as Sericocomopsis hildebrandtii. Morphologically, individuals within these lineages are similar, with one of them matching the type of Sericocomopsis meruensis. This name was formerly considered a synonym and is resurrected at species level. Cymous partial florescences are ancestral in this clade, which corresponds to the genus Cyathula as re‐circumscribed here. To the contrary, sterile flowers and bracteoles or tepals modified to hooks serving dispersal by animals appear multiple times within and outside this clade, indicating how their use as diagnostic characters for genera led to non‐monophyletic entities. For the phylogenetically isolated and morphologically distinct Cyathula orthacantha the new genus Sebsebea is described, and for Sericocomopsis pallida the new genus Evelynastra. The Achyranthes clade is characterized by solitary, fertile flowers including the genera Achyropsis and Nototrichium both of which are merged to make Achyranthes monophyletic. In addition to a treatment to establish all required nomenclatural changes and typifications, we also provide a taxonomic backbone with full synonymy for the achyranthoid subclade II.
Improving mathematics outcomes for multilingual learners in dual language programs through targeted teacher professional development
Authors: Bravo Marco A. , Mosqueda Eduardo , Téllez Kip 
Published: December 2024

AbstractProviding instruction in a student's home language through bilingual education has proven to be academically beneficial for multilingual learners (MLLs). The present study contributes to this literature by examining the possibilities and limits of a professional development program (Mathematics and Language Literacy Integration [MALLI] in Dual Language settings) with dual language (Spanish/English) teachers and the impact on elementary grade MLLs' state mathematics and English language proficiency assessment outcomes. MALLI was a year‐long professional development project that included models for integrating language and literacy into Spanish‐language mathematics instruction using Lesson Study with Video Clubs. Coarsened exact matching was utilized to establish a treatment and unbiased comparison group. MLLs taught by MALLI teachers had state mathematics assessment average standardized scores of 0.374 standard deviation units higher than comparison students whose teachers did not participate in MALLI. These results were statistically significant, equivalent to moving the performance of an average MLL from the 50th percentile to the 64.6 percentile rank. However, the effect on State English language proficiency scores was small and not statistically significant. This study illustrates the potential impact of specially designed professional development to improve MLLs' mathematics outcomes.
Trends and complications in functional endoscopic sinus surgery and balloon sinuplasty: A TriNetX database analysis
Authors: Bitner Benjamin F. , Torabi Sina J. , Nguyen Theodore V. , Pang Jonathan C. , Kuan Edward C. 
Published: December 2024

AbstractObjectivesBalloon sinuplasty (BSP) and functional endoscopic sinus surgery (FESS) have undergone changes in utilization over time. This study investigates national trends in BSP and FESS and postoperative outcomes over the last decade as well as the impact of Corona Virus Disease 2019 (COVID‐19) on these trends.MethodsThe TriNetX database was queried for patients undergoing either FESS or BSP from 1/1/2011 to 5/4/2024. Data were collected on patient demographics, diagnoses, and postoperative outcomes.ResultsA total of 1738 patients underwent BSP and 90,311 underwent FESS. A greater proportion of FESS patients had diabetes (p = 0.001), hypertension (p < 0.001), and chronic pulmonary disease, p = 0.001) compared to BSP whereas a similar proportion of patients for both cohorts had a history of ischemic heart disease (p = 0.73). Body mass index was higher for patients undergoing FESS (28.6 ± 6.5) compared to BSP (28.1 ± 6.578; p = 0.02). Overall postoperative complications were similar between BSP and FESS (odds ratio [OR] = 0.80, 95% confidence interval [CI] = 0.58–1.09) with similar rates of epistaxis (OR = 0.77, 95% CI = 0.53–1.12) and cerebrospinal fluid (CSF) leak (OR = 0.14, 95% CI = 0.01–2.25). Overall revision rate was higher for FESS (OR = 0.34, 95% CI = 0.21–0.57). Thirty‐day readmission (OR = 0.44, 95% CI = 0.29–0.66) and Emergency Department visits (OR = 0.51, 95% CI = 0.28–0.92) were less common in patients who received BSP. Surgical volume consistently increased over time for both cohorts but at a more rapid pace for BSP (425.64%) compared to FESS (274.19%) and a dramatic decrease in volume by 44.85% and 22.28%, respectively, at the onset of COVID‐19.ConclusionOverall, BSP and FESS surgical volume have steadily increased over time with a drastic reduction following the COVID‐19 pandemic. BSP and FESS carry different complication profiles emphasizing the importance of patient selection and preoperative counseling.Level of EvidenceLevel 4.
Academic productivity and industry trends of fellowship‐trained U.S. academic rhinologists
Authors: Warn Michael J. , Chan Daniella , Nguyen Theodore V. , Torabi Sina J. , Bitner Benjamin F. , Kuan Edward C. 
Published: December 2024

AbstractBackgroundAcademic productivity is believed to be correlated with years of experience and departmental rank, yet there is a paucity of granular academic data between rhinology faculty regarding departmental rank and industry engagement, and how these relate to experience.ObjectiveTo examine the interrelationships between experience, department rank and reputation, funding, industry engagement, and academic output of rhinology faculty.MethodsDemographics, academic metrics (publications, citations, h‐index, National Institutes of Health [NIH] funding), program rankings, and industry compensation for academic U.S. rhinologists through June 2022 were collected and compared between academic rank and years of experience.ResultsA cohort of 278 rhinologists were included. Full professors had greater academic metrics (all p < 0.001) and industry compensation (all p < 0.05) than associate professors, assistant professors, and private practice rhinologists. Full professors were also more likely to receive NIH funding than other groups (p < 0.001). Years of experience and industry compensation positively correlated with each other and with academic metrics (all p < 0.001) with significant jumps between the 5th–9th and 10th–14th years of practice (p < 0.001). However, early career (≤8 years) rhinologists published more articles per year than later career (>8 years) rhinologists (p < 0.001). Rhinologists at Doximity top 10 and 25 residency programs by reputation and research output and top 50 U.S. News and World Report departments had significantly greater academic metrics and NIH funding compared to those who were not (p < 0.001). Top 10 and 25 reputations was associated with increased industry compensation (p = 0.024).ConclusionsAlthough early career rhinologists published more frequently, ascending professorial rank, years of experience, and affiliation with top‐ranked departments were associated with total academic productivity. Industry engagement was linked to reputation and years of experience.