bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study of geometry-based methods and intra-arterial pressure measurements to assess the hemodynamic significance of equivocal iliac artery stenoses
Authors: Heinen Stefan GH , Huberts Wouter , van den Heuvel Daniel AF , van de Vosse Frans N , de Vries Jean-Paul PM , Delhaas Tammo 
Published: October 2018

Objectives To date, the ultimate decision to treat iliac artery stenoses in patients suffering from symptomatic peripheral arterial disease is based on the patient’s symptoms and on visual inspection of angiographical images. The primary aim of this study was to investigate the accuracy of geometry-based methods (i.e. visual inspection and quantitative vascular analysis (Viewforum version R7.2v1 Advanced vessel analysis, Philips Healthcare, Best, The Netherlands) of 3D rotational angiography) to identify the severity of equivocal iliac artery stenosis in peripheral arterial disease patients with intra-arterial hyperemic pressure measurements (gold standard) as a reference. Methods Twenty patients with symptomatic iliac artery stenoses were subjected to 3D rotational angiography. Intra-arterial pressure measurements under hyperemic conditions were performed across 24 visually identified iliac artery stenoses. Three experienced interventional-radiologists retrospectively estimated the lumen diameter reduction by visual inspection. Furthermore, quantitative vascular analysis was performed on the 3D rotational angiography data. Geometry-based estimates were classified into two groups: lumen diameter reduction of <50% (non-significant) and diameter reduction [Formula: see text]50% (significant), and compared to the intra-arterial hyperemic pressure gradients. A stenosis causing a pressure gradient (Δp) ≥10 mmHg was considered hemodynamically significant. Results Visual inspection and quantitative vascular analysis correctly identified hemodynamically significant stenoses in, respectively, 83% and 67% of the 24 iliac artery stenoses. Quantitative vascular analysis-based identification of hemodynamic significant stenoses (Δp ≥ 10 mmHg) could be optimized by lowering the threshold to a 42% lumen diameter reduction which improved the accuracy from 67% to 83%. Conclusions Visual inspection of 3D rotational angiography by experienced interventional-radiologists has an 83% accuracy to identify hemodynamic significant iliac artery stenoses (Δ p ≥10 mmHg). The use of quantitative vascular analysis software did not improve accuracy.
Dual Purpose Use of Flexor Hallucis Longus Tendon for Management of Chronic Achilles Tendon Ruptures
Authors: Khalid Mohammed A. , Weiss William M. , Iloanya Michael , Panchbhavi Vinod K. 
Published: October 2018

Background: Chronic Achilles tendon ruptures are uncommon and increase long-term morbidity when untreated. There is no standard treatment for this condition. Methods: Chronic Achilles tendon rupture was repaired in 10 patients by harvesting the flexor hallucis longus tendon (FHL) using a minimally invasive technique. It was then transferred to the calcaneus and the remnant used to bridge the gap for reconstructing the Achilles tendon itself. The patients were assessed using the American Orthopaedic Foot and Ankle Score (AOFAS) Ankle-Hindfoot Scale. Results: Patients were evaluated postoperatively to assess pain, function, and alignment of the ankle and hindfoot. Average follow-up time was 30.9 months (range = 17-43 months). The average postoperative AOFAS score was 78.5 (range = 54-94). The average postoperative score for pain was 33.5 out of 40; for function, 38.7 out of 50; and for alignment, 6.3 out of 10. A single surgical site infection requiring Incision and Drainage (I&D) was the only operative complication noted. No patient developed a significant deformity of the hallux after transfer. Conclusions: FHL transfer using a minimally invasive harvest for the treatment of chronic Achilles tendon ruptures produces good to excellent outcome measures as judged by an AOFAS score of 75 or greater while minimizing risk to the medial neurovascular bundle. Levels of Evidence: Case series, Level IV: Retrospective
Usefulness of IMP3 and FOXP3 to predict metastasis of cutaneous melanomas
Authors: Ocanha-Xavier Juliana Polizel , Xavier-Junior José Cândido C. , Marques Mariângela Esther Alencar 
Published: October 2018

Abstract
Background
Melanoma still has considerable mortality in spite of improvements in diagnosis and treatment. Unfortunately, current diagnostic procedures cannot predict precisely its biological behavior, what urges specialists in searching new better biomarkers of lousy prognosis. The objective of the study was to evaluate IMP3 and FOXP3 expression in primary skin melanoma lesions and to correlate with the presence of metastasis.

Methods
A retrospective cohort study analyzed 112 patients diagnosed with Melanoma, from 2003 to 2011, from a public health service. Samples from the primary lesion were analyzed by two pathologists and one dermatologist to ensure histological subtype, Breslow, the presence of ulceration, mitosis and histological regression. From the species stored, FOXP3 and IMP3 immunohistochemistry staining were performed. Demographic, clinical and evolution aspects of the patients were obtained from records, in the year of 2015. It was considered statistically significant when p-value < 0.05.

Results
The majority of specimens had 25% or fewer cells stained with FOXP3 or IMP3. Their positivity could not be related to the occurrence of metastasis (p = 0.947 and p = 0.936, respectively).

Conclusion
There is no evidence of benefit in using IMP3 or FOXP3 as prognostic markers in primary melanomas in our population.
Current topics on prostate and bladder pathology
Authors: Athanazio Daniel Abensur , Souza Vinicius Carrera 
Published: October 2018

Abstract
Background
This review addresses current issues from the daily practice of prostate and bladder diagnostic pathology.

Main text
In the last few years, many recommendations and clarifications were available from 2014 International Society of Urologic Pathology consensus, 2016 World Health Organization blue book and 2017 8th edition of American Joint Committee on Cancer Staging System.

Conclusion
We focus here on nine topics which are relevant based on their common appearance in daily practice, clinical relevance and need to improve communication between pathology reports and clinicians.
Effects of Joint Kinetics on Energy Cost during Repeated Vertical Jumping
Authors: SEKI KEITARO , KYRÖLÄINEN HEIKKI , NUMAZU NAOKI , OHYAMA-BYUN KEIGO , ENOMOTO YASUSHI 
Published: October 2018

ABSTRACTPurposeThe present study was designed to investigate the effects of lower limb joint kinetics on energy cost during jumping.MethodsEight male middle and long-distance runners volunteered for the study. The subjects were asked to repeat vertical jumps at a frequency of 2 Hz for 3 min on a force platform in three different surface inclination conditions: Incline (+8°), Level (0°), and Decline (−8°). Sagittal plane kinematics were obtained using a high-speed video camera. Simultaneously, ground reaction forces and EMG of the lower limb muscles were recorded. Energy cost was calculated using steady-state oxygen uptake, respiratory ratio, and vertical distance of the body.ResultsIn all conditions, energy cost correlated positively with total mechanical work of the knee joint (r= 0.636,P< 0.01), but negatively with total mechanical work of the ankle joint (r= −0.584,P< 0.01). The muscle–tendon complex length of the gastrocnemius and soleus muscles were significantly longer in incline than in level and decline. The gastrocnemius muscle showed different activity pattern in decline as compared with the incline and level conditions.ConclusionsThe present study revealed that the ankle and knee joint kinematics and, therefore muscles’ coordination are associated with energy cost during repeated vertical jumping. The lower limb joints contributed different efficiencies to generate the same total mechanical work in repeated vertical jumping on different surface inclinations. Energy cost was smaller when mechanical work was mainly done by ankle joint. Whereas, when the ankle joint did less mechanical work, the knee and/or hip joints compensated for the lack of mechanical work of the ankle joint and energy cost was increased.
Prognostic Performance of Prospective versus Retrospective Electrocardiographic Gating in Coronary Computed Tomographic Angiography
Authors: Velankar Pradnya , Chaikriangkrai Kongkiat , Dewal Ninad , Bala Sayf Khaleel , Elferjani Belqis , Alchalabi Sama , Chang Su Min 
Published: October 2018

Coronary computed tomographic angiography (CCTA) with prospective electrocardiographic gating reduces radiation exposure, but its prognostic power for predicting cardiovascular risk in patients with suspected CAD has not been fully validated. To determine whether prospective gating performs as well as retrospective gating in this population, we compared these scan modes in patients undergoing 64-slice CCTA.
From January 2009 through September 2011, 1,407 patients underwent CCTA; of these, 915 (mean age, 57.8 ± 13.5 yr; 54% male) had suspected coronary artery disease at the time of CCTA and were included in the study. Prospective gating was used in 195 (21%) and retrospective gating in 720 (79%). The mean follow-up duration was 2.4 ± 0.9 years.
Overall, 390 patients (42.6%) had normal results on CCTA, 382 (41.7%) had nonobstructive coronary artery disease, and 143 (15.6%) had obstructive disease. Major adverse cardiac events occurred in 32 patients (3.5%): 11 cardiac deaths, 15 late revascularizations, and 6 nonfatal myocardial infarctions. Total event occurrences were similar in both groups (retrospective, 3.8%; prospective, 2.6%; P=0.42), as were the occurrences of each type of event. On adjusted multivariate analysis, nonobstructive (P=0.015) and obstructive (P <0.001) coronary artery disease were independently associated with major adverse cardiac events. Scan mode was not a predictor of outcome. The mean effective radiation dose was 4 ± 2 mSv for prospective compared with 12 ± 4 mSv for retrospective gating (P <0.01).
The prognostic value of CCTA with prospective electrocardiographic gating compares favorably with that of retrospective gating, and it involves significantly less radiation exposure.
Fatma Aliye Hanım: Gender Debates in Turkey
Authors: Direk Zeynep 
Published: October 2018

Abstract
This essay explores the late nineteenth and early twentieth Century gender debates in the late Ottoman Empire, and the early Republic of Turkey with a focus on Fatma Aliye’s presence in the public space, as the first Ottoman woman philosopher, novelist, and public intellectual. I choose to concentrate on her because of the important stakes of the gender debates of that period, and the ways in which they are echoed in the present can be effectively discussed by reflecting on the ways in which Fatma Aliye is read, presented, and received. In the first part of this paper, I talk about Fatma Aliye’s life and experience of her gender as a woman, and point to her key interests as a writer and philosopher. In the second part, I situate her in the political history of feminism during the Rearrangement Period (Tanzimat), the Second Constitutional Era (II. Meşrutiyet), and the institution of the modern Republic of Turkey. Lastly, in the third part, I discuss the diverse ways in which she is interpreted in contemporary Turkey. I explore the political impact of the reception of Fatma Aliye as an intellectual figure on the current gender debates in Turkey.
ʿIlm al-kalām in Mauretanien anhand maurischer Kommentare zur Iḍāʾat ad-duǧunna
fī iʿtiqād ahl as-sunna von al-Maqqarī (st. 1041/1632)
Authors: Graf Gunhild 
Published: October 2018

Abstract
The present article intends to contribute to the research on the kalām (“theology”) in Mauritania. So far, this particular Islamic science has received little attention of Islamic studies outside Mauritania. Around a dozen Mauritanian and non-Mauritanian commentaries on the highly popular didactic poem Iḍāʾat ad-duǧunna of al-Maqqarī – until today part of the education curriculum in the cultural area of the Western Sahara – provide the basis of the present paper which is divided in two parts: Part one presents some characteristic features of Mauritanian literature and the status of ʿilm al-kalām in Mauritania. Part two deals with the Iḍāʾa and its (Mauritanian) commentaries. Some selected key verses of the Iḍāʾa and their interpretation by various commentators are discussed here. Particular attention is paid to autobiographical notes and the elaboration on some special terms (for example tauḥīd, ʿilm, auwal wāǧib). Further topics addressed include the dialogue between al-Ǧubbāʾī and al-Ašʿarī and the report on Ibn Barraǧān’s prediction of the conquest of Jerusalem from the crusaders by the Muslims in the year 583 H. Since many Mauritanian manuscripts about kalām have not been edited to the present day, even an approximate overview on the Mauritanian kalām literature is still out of sight. However, the investigation of the Mauritanian ʿilm al-kalām as a subbranch of studies on later kalām since the seventeenth century promises to provide highly relevant and intriguing insights.
Unfertige Studien 4: Skrupelhaftigkeit
Authors: van Ess Josef 
Published: October 2018

Abstract
The topic of this article is the K. al-Makāsib (“A Note on Earnings”), an early theological text, written by al-Muḥāsibī (d. 243/857). While several studies on the first part exist, the second part has been largely ignored. Its subject is the concept of waraʿ (“scrupulousness”). The article contains a full translation and a commentary of the second part of the K. al-Makāsib, based on the only preserved manuscript. At the beginning of the text, waraʿ is defined as “to abstain from anything which displeases God.” This is about more than just the avoidance of what is forbidden and the fulfilment of what is commanded. There exist doubtful things (shubuhāt), for which it is unclear whether they fall under the forbidden or not. Piety demands avoidance of them. While religious law relates to human actions only, al-Muḥāsibī insists on the significance of “acting with the heart”. The pious must undertake a soul-searching (muḥāsaba) before taking any action. Many concrete examples of scrupulous behavior are mentioned. One topic is how to earn a living. Some recommend earning it by the work of one’s hands, others prefer begging, and yet others prefer to live off rubbish, or even off herbage alone. Asceticism with its different forms of starvation is discussed. A larger topic is the question of cooperation with a potentially immoral government, and, more narrowly, how to proceed when illegal money is received, particularly in the case of inheritance, or what it means “to help” someone else by committing forbidden acts.
Should phosphatidylethanol be currently analysed using whole blood, dried blood spots or both?
Authors: Nguyen Van Long , Fitzpatrick Michael 
Published: October 2018

Abstract
Phosphatidylethanol (PEth) are phospholipids produced through non-oxidative ethanol metabolism. They accumulate in red blood cells and have been traditionally analysed in whole blood as potential biomarkers for moderate to long-term alcohol consumption. More recently, their analysis in dried blood spots has been gaining favour, namely, due to the ease in sampling, transport and storage conditions required. This paper aims at providing a short comparative review between analysing PEth in whole blood and dried blood spots and the potential pitfalls that researchers may face when setting up PEth testing for clinical use.
The multimodal marking of aspect: The case of five periphrastic auxiliary constructions in North American English
Authors: Hinnell Jennifer 
Published: October 2018

AbstractCognitive linguistics (CL) has, in recent years, seen an increase in appeals to include multiple modalities in language analyses. While individual studies have incorporated gesture, gaze, facial expression, and prosody, among other modalities, CL has yet to completely embrace the systematic analysis of face-to-face interaction. Here, I present an investigation of five aspect-marking periphrastic constructions in North American English. Using naturalistic interactional data (n=250) from the Red Hen archive, this study establishes a multimodal profile for auxiliary constructions headed by one of five highly aspectualized verbs: continue, keep, start, stop, and quit, as in The jackpot continued to grow and He quit smoking. Results show that gesture timing, the structure of the gesture stroke, and gesture movement type, are variables that iconically and differentially represent distinctive aspectual conceptualizations. This study enhances our understanding of aspectual representation in co-speech gesture and informs the ongoing debate within CL and construction grammar circles of what constitutes conventionalization, or what constitutes a construction (mono- or multimodal).
Time will tell: Temporal landmarks influence metaphorical associations between space and time
Authors: Li Heng , Cao Yu 
Published: October 2018

AbstractAccording to the Temporal Focus Hypothesis (TFH), people’s implicit spatial conceptions are shaped by their temporal focus. Whereas previous studies have demonstrated that people’s cultural or individual differences related to certain temporal focus may influence their spatializations of time, we focus on temporal landmarks as potential additional influences on people’s space-time mappings. In Experiment 1, we investigated how personally-related events influence students’ conceptions of time. The results showed that student examinees were more likely to think about time according to the past-in-front mapping, and student registrants, future-in-front mapping. Experiment 2 explored the influence of calendar markers and found that participants tested on the Chinese Spring Festival, a symbol of a fresh start, tended to conceptualize the future as in front of them, while those tested on the Tomb Sweeping Day, an opportunity to remember the ancestors, showed the reversed pattern. In Experiment 3, two scenarios representing past or future landmarks correspondingly were presented to participants. We found that past-focused/future -focused scenarios caused an increase in the rate of past-in-front/future-in-front responses respectively. Taken together, the results from these three studies suggest that people’s conceptions of time may vary according to temporal landmarks, which can be explained by the TFH.
C2 Agility for Emergency Management: Examining the Katrina and Sandy Responses
Authors: Earle Caroline R. 
Published: October 2018

Abstract
The Command and Control (C2) Agility theory developed by experts from the Command and Control Research Program based upon analysis of military operations, posits that a C2 approach is characterized by three dimensions: (1) allocation of decision rights, among entities, (2) patterns of interaction, and (3) distribution of information. An entity’s C2 approach is agile when these three dimensions can be changed as required due to a change in circumstances. The Institute for Defense Analyses has produced a handbook C2 by Design to guide operationalization of the C2 Agility theory. C2 agility becomes salient as complexity increases; and the complex, dynamic nature of disaster response environments suggests the applicability of C2 Agility theory to emergency management. This article builds on early NATO study panel findings that used disaster response case studies to validate C2A theory, and draws on existing case literature to identify what factors influenced C2A during Hurricane Katrina and explore how lessons learned from that response impacted C2A during the subsequent US response to Hurricane Sandy. The analysis uses C2A assessment factors from C2 by Design to examine these cases and recommends how the US government can achieve improved C2A during future responses to complex disasters.
Source identification problems for hyperbolic differential and difference equations
Authors: Ashyralyev Allaberen , Emharab Fathi 
Published: October 2018

Abstract
In the present study, a source identification problem for a one-dimensional hyperbolic equation is investigated. Stability estimates for the solution of the source identification problem are established. Furthermore, a first-order-of-accuracy difference scheme for the numerical solution of the source identification problem is presented. Stability estimates for the solution of the difference scheme are established. This difference scheme is tested on an example, and some numerical results are presented.
Crystal structure of N-(4-methoxybenzyl)pyridazin-3-amine- a rare Z′ = 4 structure, C12H13N3O
Authors: Lou Xin-Hua , Zhou Qing-Li , Liu Wen-Yuan , Hu Xue-Qing 
Published: October 2018

Abstract
C12H13N3O, triclinic, P1̄ (no. 2), a = 10.2233(9) Å, b = 10.2902(9) Å, c = 24.2253(19) Å, α = 86.607(7)°, β = 88.529(7)°, γ = 62.515(9)°, V = 2256.9(4) Å3, Z = 8, R
gt(F) = 0.0425, wR
ref(F
2) = 0.1239, T = 291(2) K.
Application of lactic acid derived from food waste on pathogen inactivation in fecal sludge: a review on the alternative use of food waste
Authors: Odey Emmanuel Alepu , Abo Bodjui Olivier , Li Zifu , Zhou Xiaoqin 
Published: October 2018

AbstractFood waste generation and disposal have led to several environmental problems, especially in developing countries. This phenomenon is partly because most cities rapidly urbanize, which results in population increase, urban settlement and waste generation. Improper management of waste has continued to create environmental problems. These problems have indeed interfered with the inadequate measures in managing other organic waste such as food waste. Food waste can be fermented and used for pathogen inactivation in fecal sludge (FS). The continual decrease in global crop production due to soil erosion, nutrient runoff and loss of organic matter has generated interest in using FS for soil amendment. However, due to the high number of pathogens in FS that are harmful to humans, FS must be treated before being used in agriculture. Thus, given the high amounts of food waste generated globally and the lactic acid potential of fermented food waste, several researchers have recently proposed the use of fermented food waste to suppress pathogens in FS. This review presents the various approaches in pathogen inactivation in FS using different types of food waste. On the basis of the literature review, the major problems associated with the generation, collection and application of food waste in pathogen inactivation in FS are discussed. Moreover, the trends and challenges that concern the applicability of each method are critically reviewed.