bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pilot testing of the first version of the European Association for Palliative Care basic dataset: A mixed methods study
Authors: Sigurdardottir Katrin Ruth , Hjermstad Marianne J , Filbet Marilene , Tricou Colombe , McQuillan Regina , Costantini Massimo , Autelitano Cristina , Bennett Michael I , Haugen Dagny Faksvåg 
Published: April 2019

Background: Inadequate description of palliative care cancer patients in research studies often leads to results having limited generalizability. To standardize the description of the sample, the European Association for Palliative Care basic data set was developed, with 31 core demographic and disease-related variables. Aim: To pilot test the data set to check acceptability, comprehensibility and feasibility. Design: International, multi-centre pilot study at nine study sites in five European countries, using mixed methods. Setting/participants: Adult cancer patients and staff in palliative care units, hospices and home care. Results: In all, 191 patients (544 screened) and 190 health care personnel were included. Median time to fill in the patient form was 5 min and the health care personnel form was 7 min. Ethnicity was the most challenging item for patients and requires decisions at a national level about whether or how to include. Health care personnel found weight loss, principal diagnosis, additional diagnoses and stage of non-cancer diseases most difficult to respond to. Registration of diagnoses will be changed from International Statistical Classification of Diseases and Related Health Problems, 10th version code to a predefined list, while weight loss and stage of non-cancer diseases will be removed. The pilot study has led to rewording of items, improvement in response options and shortening of the data set to 29 items. Conclusion: Pilot testing of the first version of the European Association for Palliative Care basic data set confirmed that patients and health care personnel understand the questions in a consistent manner and can answer within an acceptable timeframe. The pilot testing has led to improvement, and the new version is now subject to further testing.
Complete remission for 4 years with crizotinib in advanced ALK-positive non-small cell lung cancer after thoracostomy for empyema
Authors: Van Damme Eufra , Kiselinova Maja , Van Schoote Elke 
Published: April 2019

Introduction Anaplastic lymphoma kinase ( ALK) gene translocation occurs in 3%–5% of patients with non-small cell lung cancer (NSCLC), typically in younger patients. Crizotinib (tyrosine kinase inhibitor) has been considered as the standard of care for advanced ALK-positive lung cancer but it only gives a median progression-free survival of 7.7–11 months. Case A 41-year-old old man, former smoker, was diagnosed with NSCLC in the right lung with manifest pleural effusion. This case was complicated by a pleural empyema and because of a trapped lung, there was an indication for the construction of a thoracostomy. After confirmation of the ALK translocation, therapy with crizotinib was started. After 8 weeks, there was excellent response, and 6 months later, all lesions were undetectable on CT scan. There was also complete healing of the thoracostomy wound. Conclusion This case describes a relatively young patient with a poor prognosis but with a remarkable and long-term response to crizotinib monotherapy.
Minor Head Injury Symptoms and Recovery From Whiplash Injury: A 1-Year Prospective Study
Authors: Kasch Helge , Jensen Luana Leonora 
Published: April 2019

Aim: To examine concussion-related disability in neck injuries, the Rivermead Head Injury Follow-Up Questionnaire (RHFUQ) was applied. Furthermore, we wanted to investigate symptoms found in post-concussion syndrome (PCS) and global pain, neck pain intensities obtained from acute whiplash patients within 1 week and at 6 months after injury in a prospective study on 1-year work disability. Methods: A total of 143 consecutive acute whiplash-injured patients were admitted to the study from the Emergency Unit (Aarhus University Hospital). Patients with direct head trauma or reported retro- or anterograde amnesia were excluded from the study. Average neck pain and global pain intensity were measured on a Visual Analogue Scale (VAS 0-10). The RHFUQ (10 items, score from 0 to 4, total score from 0 to 40) was fulfilled after 1 week and 6 months. Patients underwent neurological examination within 1 week after injury. Recovery (return to work) was assessed 1 year post-injury. Results: In total, 97% completed the study, and 9% (12/138) did not recover. Non-recovered patients reported more neck pain and global pain after 1 week ( P < .003) and 6 months ( P < .008) and higher PCS symptom score after 1 week ( P < .001) and 6 months ( P < .002). Using the RHFUQ total score as a predictive test, a receiver-operating characteristic curve (ROC) area of 0.77 (0.61-0.92) and a cut-off at 10 points revealed a sensitivity of 75% and a specificity of 67.2%. At 1 week, 8 of 10 items reached higher scores among non-recovered and 10 of 10 items after 6 months post-injury. Conclusions: RHFUQ is useful in acute whiplash patients for predicting 1-year work disability. PCS-related symptoms along with neck pain and global pain are more burdensome in the non-recovered group. This emphasizes that post-concussion symptoms are not a sign of brain injury alone, but are found in other types of mishaps like whiplash injuries.
What factors influence healthcare professionals to refer children and families to paediatric psychology?
Authors: O’Connell Christine , Shafran Roz , Camic Paul M , Bryon Mandy , Christie Deborah 
Published: April 2019

Objectives: This study aimed to investigate factors influencing referral of children with physical illness to paediatric psychology. Due to high rates of mental health problems within this population, studies have shown that referral to paediatric psychology should be increased. However, few studies have examined factors shaping healthcare professionals’ referral behaviour. Methods: This study used the theory of planned behaviour to develop a questionnaire which explores factors influencing the referral of children and families to paediatric psychology. Psychometric properties of the questionnaire were examined. Results: The questionnaire was found to have good reliability and validity. The main constructs of the theory of planned behaviour were useful in predicting intention to refer to paediatric psychology. Specific beliefs about referral were shown to influence intention to refer. Conclusion: Findings suggest that individual attitudes and beliefs can impact healthcare professionals’ referral behaviour, indicating that multidisciplinary interventions and inter-professional education relating to the psychological aspects of illness are required.
Effect of Skeletal Paracrine Signals on the Proliferation of Interzone Cells
Authors: Thampi Parvathy , Dubey Rashmi , Lowney Rachael , Adam Emma N. , Janse Sarah , Wood Constance L. , MacLeod James N. 
Published: April 2019

Objective Articular cartilage in mammals has limited intrinsic capacity to repair structural defects, a fact that contributes to the chronic and progressive nature of osteoarthritis. In contrast, Mexican axolotl salamanders have demonstrated the remarkable ability to spontaneously and completely repair large joint cartilage lesions, a healing process that involves interzone cells in the intraarticular space. Furthermore, interzone tissue transplanted into skeletal defects in the axolotl salamander demonstrates a multi-differentiation potential. Cellular and molecular mechanisms of this repair process remain unclear. The objective of this study was to examine whether paracrine mitogenic signals are an important variable in the interaction between interzone cells and the skeletal microenvironment. Design The paracrine regulation of the proliferation of equine interzone cells was evaluated in an in vitro co-culture system. Cell viability and proliferation were measured in equine fetal interzone cells after exposure to conditioned medium from skeletal and nonskeletal primary cell lines. Steady-state expression was determined for genes encoding 37 putative mitogens secreted by cells that generated the conditioned medium. Results All experimental groups of conditioned media elicited a mitogenic response in interzone cells. Fetal anlage chondrocytes ( P < 0.0001) and dermal fibroblasts ( P < 0.0001) conditioned medium showed a significantly higher mitogenic potential compared with interzone cells. Conditioned medium from bone marrow–derived cells elicited a significantly higher proliferative response relative to that from young adult articular chondrocytes ( P < 0.0001) or dermal fibroblasts ( P < 0.0001). Sixteen genes had expression patterns consistent with the functional proliferation assays. Conclusions The results indicate a mitogenic effect of skeletal paracrine signals on interzone cells.
Assessment of Rwandan diabetic patients’ needs and expectations to develop their first diabetes self-management smartphone application (Kir’App)
Authors: Kabeza Claudine B. , Harst Lorenz , Schwarz Peter E. H. , Timpel Patrick 
Published: April 2019

Background: Knowledge of and coping with diabetes is still poor in some communities in Rwanda. While smartphone applications (or apps) have demonstrated improving diabetes self-care, there is no current study on the use of smartphones in the self-management of diabetes in Rwanda. Methods: The main objective of this study was to assess the needs and expectations of Rwandan diabetic patients for mobile-health-supported diabetes self-management in order to develop a patient-centred smartphone application (Kir’App). Results: Convenience sampling was used to recruit study participants at the Rwanda Diabetes Association. Twenty-one patients participated in semi-structured, in-depth, face-to-face interviews. Thematic analysis was performed using Mayring’s method of qualitative content analysis. Conclusions: The study included 21 participants with either type 1 (female = 5, male = 6) or type 2 (female = 6, male = 4) diabetes. Participants’ age ranged from 18 to 69 years with a mean age of 35 and 29 years, respectively. Eight main themes were identified. These were (a) diabetes education and desired information provision; (b) lack of diabetes knowledge and awareness; (c) need for information in crisis situations; (d) required monitoring and reminder functions; (e) information on nutrition and alcohol consumption; (f) information on physical activity; (g) coping with burden of disease, through social support and network; (h) app features. This study provides recommendations that will be used to design the features of the first Rwandan diabetes self-management smartphone application (Kir’App). The future impact of the application on the Rwandan diabetic patients’ self-management capacity and quality of life will be evaluated afterwards.
Stretching the Comfort Zone: Using Early Clinical Contact to Influence Professional Identity Formation in Medical Students
Authors: Schei Edvin , Knoop Hannah Sofie , Gismervik Malene Nordal , Mylopoulos Maria , Boudreau J Donald 
Published: April 2019

Purpose: To explore first-year medical students’ affective reactions to intimate encounters with severely sick patients in their homes, within a curricular innovation targeting the development of a patient-centered professional identity. Background: Early patient encounters create complex emotional challenges and constitute fertile ground for professional identity formation. The literature indicates that students often learn, largely through the hidden curriculum, to avoid and suppress emotion. This can culminate in mental health problems and loss of empathy. Method: A qualitative descriptive analysis of 28 randomly selected, mandatory, reflective essays focused on a home visit to a previously unknown patient, in an unsupervised group of 4 students, within the context of a structured course called Patient Contact—PASKON. Results: Students described a wide range of affect-laden responses, positive and negative, elicited by the home visits. The observations were typically related to loss of control, struggles to behave “professionally,” and the unmasking of stereotypes and prejudices. Conclusions: Medical students’ initial clinical encounters elicit emotional responses that have the potential to serve as triggers for the development of emotional maturity, relational skills, and patient-centered attitudes. Conversely, they can foreground uncertainty and lead to defensive distancing from patients’ existential concerns. The findings point to a role for structured educational strategies and supervision to assist students in the emotion work necessary in the transition from a “lay” to a “medical” identity.
WITHDRAWN—Administrative Duplicate Publication: Complementary Therapies as a Strategy to Reduce Stress and Stimulate the Immunity of Women With Breast Cancer
Authors: Abrahão Camila Aparecida , Bomfim Emiliana , Lopes-Júnior Luís Carlos , Pereira-da-Silva Gabriela 
Published: April 2019

Abrahão, CA, Bomfim E, Lopes-Júnior LC, Pereira-da-Silva, G. Complementary Therapies as a Strategy to Reduce Stress and Stimulate the Immunity of Women With Breast Cancer. Journal of Evidence-Based Integrative Medicine. 2019; 24. Due to an administrative error, this article was accidentally published twice in Volume 24 with different DOIs. The correct and citable version of the article remains: Abrahão, CA, Bomfim E, Lopes-Júnior LC, Pereira-da-Silva, G. Complementary Therapies as a Strategy to Reduce Stress and Stimulate Immunity of Women With Breast Cancer. Journal of Evidence-Based Integrative Medicine. 2019; 24. doi: 10.1177/2515690X19834169
Immune Checkpoint Blockade in PD-L1–Positive Platinum-Refractory Cervical Carcinoma
Authors: Tewari Krishnansu S. 
Published: April 2019

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 36-year-old white married mother of two small children presented with intermenstrual bleeding, dyspareunia, and pelvic pain. Because of significant lapses in health care coverage, she had had only sporadic screening for cervical cancer over the past 15 years. On evaluation with a vaginal speculum, her cervix was found to have been replaced by a friable lesion 5 cm in diameter. Biopsy revealed poorly differentiated, squamous cell carcinoma. Bimanual pelvic and rectovaginal examination, as well as radiographic imaging studies, were consistent with an International Federation of Gynecology and Obstetrics (FIGO) stage IB3 squamous cell carcinoma of the cervix. She was treated with cisplatin-based chemoradiation (40 mg/m2 body surface area once per week with a planned total dose of 50 Gy using intensity modulated radiotherapy) plus high-dose-rate intracavitary brachytherapy (to bring the total dose to point A to 80 to 85 Gy). Despite missing eight radiotherapy sessions because of transportation issues, she had a complete clinical response. Fourteen months later, she developed severe pelvic and right flank pain. In the clinic, she was cachectic and reported significant abdominal discomfort that kept her from eating well over the past several months. She was no longer able to work as a medical assistant and spent most of her time confined to her apartment. Physical examination demonstrated a fixed, firm pelvic mass; a computed tomography-guided biopsy confirmed recurrent carcinoma, and staging scans disclosed a pulmonary metastasis.
Evolution of the Oropharynx Cancer Epidemic in the United States: Moderation of Increasing Incidence in Younger Individuals and Shift in the Burden to Older Individuals
Authors: Tota Joseph E. , Best Ana F. , Zumsteg Zachary S. , Gillison Maura L. , Rosenberg Philip S. , Chaturvedi Anil K. 
Published: April 2019

PURPOSE Human papillomavirus–positive oropharynx cancer incidence has increased rapidly in cohorts of US white men born during the 1930s to 1950s. It is unknown how the trajectory of the oropharynx cancer epidemic may be changing in the United States. METHODS Using US cancer registry information, we investigated whether increases in oropharynx cancer have continued into recent birth cohorts and forecasted the future burden across age, sex, and race/ethnicity subgroups. Log-linear Joinpoint regression and age-period-cohort models were used to evaluate incidence trends during 1992 to 2015 and projections through 2029. RESULTS Among white men, oropharynx cancer incidence increased rapidly in individuals born during 1939 to 1955 (5.3% per 2-year birth cohort; 95% CI, 4.8% to 5.7%), but this rate of increase significantly moderated in individuals born during 1955 to 1969 (1.7% per 2-year birth cohort; 95% CI, 1.0% to 2.4%). Should these birth-cohort trends continue, from 2016 to 2029 we forecast that incidence will increase dramatically in older white men 65 to 74 years of age (from 40.7 to 71.2 per 100,000) and 75 to 84 years of age (from 25.7 to 50.1 per 100,000), moderately in white men 55 to 64 years of age (from 40.3 to 52.0 per 100,000), and remain stable in white men 45 to 54 years of age (approximately 18 per 100,000). Accounting for population growth, we project an increase in annual number of cases in the United States from 20,124 (95% CI, 19,779 to 20,469) in 2016 to 30,629 (95% CI, 29,413 to 31,845) in 2029, primarily driven by older individuals (age ≥ 65 years; from 7,976 [95% CI, 7,782 to 8,172] to 18,072 [95% CI, 17,271 to 18,895]) and white men (from 14,453 [95% CI, 14,142 to 14,764] to 22,241 [95% CI, 21,119 to 23,364]). CONCLUSION The exponential increase in oropharynx cancer incidence in young white US men has ebbed, and modest increases are occurring/anticipated in cohorts born after 1955. Continued strong increases in incidence in cohorts born before 1955, and an approximate 50% increase in size of the US population age 65 years or older through 2029, portend a substantial shift in burden to elderly white men.
Lutein and zeaxanthin: The possible contribution, mechanisms of action and implications of modern dietary intake for cognitive development in children.
Authors: Loskutova Ekaterina , Shah Kajal , Flitcroft Ian D. , Setti Annalisa , Butler John S. , Nolan Yvonne , Paudel Nabin , Loughman James 
Published: April 2019

Background:Studies suggest that lutein and zeaxanthin may be important for cognitive development in children, but a comprehensive evidence synthesis is lacking. The purpose of this evidence synthesis was to analyse the available data regarding the role of lutein and zeaxanthin for cognition in children and propose a theoretical basis for future studies.Methods:The PubMed, Scopus, the ISRCTN registry and Cochrane Library databases were searched for studies that evaluated the relationship between lutein and zeaxanthin and cognitive function in children. Reference list and ancestry searches were performed on relevant articles. A total of 543 articles were identified, of which six cross-sectional studies were included.Results:The literature search revealed that the evidence concerning the effect of lutein and zeaxanthin on cognition in children is sparse. However, there is some preliminary evidence indicating a positive association between lutein and zeaxanthin and cognition in childhood.Conclusions:The cross-sectional nature of the few studies available and the lack of RCT data indicates a need for further investigation before any firm conclusions can be drawn.
How to measure a Hill–Sachs lesion: a systematic review
Authors: Maio Marta , Sarmento Marco , Moura Nuno , Cartucho António 
Published: April 2019

Quantifying bone loss is important to decide the best treatment for patients with recurrent anterior glenohumeral instability. Currently, there is no standard method available to make a precise evaluation of the Hill–Sachs lesion and predict its engagement before the surgical procedure. This literature review was performed in order to identify existing published imaging methods quantifying humeral head bone loss in Hill–Sachs lesions. Searches were undertaken in Scopus and PubMed databases from January 2008 until February 2018. The search terms were “Hill-Sachs” and “measurement” for the initial search and “Hill–Sachs bone loss” for the second, to be present in the keywords, abstracts and title. All articles that presented a method for quantifying measurement of Hill–Sachs lesions were analysed. Several methods are currently available to evaluate Hill–Sachs lesions. The length, width and depth measurements on CT scans show strong inter and intra-observer correlation coefficients. Three-dimensional CT is helpful for evaluation of bony injuries; however, there were no significant differences between 3D CT and 3D MRI measurements. The on-track off-track method using MRI allows a simultaneous evaluation of the Hill–Sachs and glenoid bone loss and also predicts the engaging lesions with good accuracy. Cite this article: EFORT Open Rev 2019;4:151-157. DOI: 10.1302/2058-5241.4.180031
Titanium dioxide fiber saturable absorber for Q-switched fiber laser generation in the 1-micrometer region
Authors: Rahman M. F. A. , Reddy P. H. , Paul M. C. , Das S. , Dhar A. , Baharom M. F. , Latiff A. A. , Rusdi M. F. M. , Wang P. , Dimyati K. , Harun S. W. 
Published: April 2019

A passively

Q

-switched ytterbium-doped fiber laser
(YDFL) operating at 1062 nm was demonstrated by using a segment of
20 cm titanium dioxide-doped fiber saturable absorber
(

TiO

2

DF

SA). The

Q

-switched YDFL emerged stably with
tunable repetition rates ranging from 32 kHz to 53 kHz as the pump
power rose from 109 mW to 233 mW. Within this range of pump power, a
maximum output power of 10.1 mW, maximum peak power of 75 mW, and
maximum pulse energy of 191 nJ were obtained. The narrowest pulse
width of 2.55 μs was attained at the maximum pump power of 233 mW,
while the signal-to-noise ratio of the fundamental frequency was
47 dB. This demonstration reveals that the proposed

TiO

2

DF

SA is feasible for constructing a
flexible and reliably stable

Q

-switched pulsed fiber laser in the
1-micrometer region.
Optimization of Two Area AGC based Power System Using PSO Tuned Fuzzy PID Controller and PSO Trained SSSC And TCPS
Authors: Eappen Geoffrey , Shankar T. 
Published: April 2019

Automatic generation control or AGC system is significant controlling system that operates efficiently to balance the load and generation in power system at minimum cost for economical operation. System frequency will vary from nominal value if there is mismatch occurs between generation and demand. Due to this high frequency deviation system may breakdown. A very fast, reliable and accurate controller is needed to maintain the system frequency within the range to maintain stability. In this paper the proposed model consisting of PID controller whose parameters have been optimized using PSO tuned Fuzzy Logic Controller and itâ€™s been compared with conventional PSO-PID controller. Each control area in power systems includes the dynamics response of the systems. The results contained in this paper present the strength of the particle swarm optimizer for tuning the Fuzzy based PID controller parameter for two area power system network, for better performance PSO trained SSSC and TCPS has been introduced to the system. The enhancement in the dynamic response of the power system network is verified. The output response of the proposed work is compared with conventional PSO-PID & PSO Fuzzy-PID based AGC system. Simulation experiments so conducted in MATLAB showed that the proposed system outperformed the conventional one by achieving better response.Â Â