bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a Consolidated Research Career Competency Framework for Allied Health Professionals
Authors: Harris Jennifer Deborah , Grafton Kate , Cooke Jo 
Published: July 2019

Abstract
Background
Allied Health Professionals (AHPs) form a significant part of the healthcare workforce, and have a great potential to improve services through research and research informed practice. However, there is a lack of tradition in undertaking research alongside practice in these professional groups. Barriers include clinical caseload pressures, a lack of training and consequent lack of confidence in practitioners. Practice managers are ill-equipped to monitor and guide staff research development. Uni-professional competency frameworks can act as further barriers to research culture across the healthcare system that is moving toward multi-disciplinary research focussing on the patient. A common framework, acceptable to all AHPs might be helpful in planning and developing clinical career pathways.
Methods
Aim: to develop a consolidated framework of research competency to help plan and guide research activity throughout AHP clinical-academic careers. The study was conducted in three phases. Phase one identified existing AHP research frameworks (AHPRF) through expert consultations and literature searches. Phase two involved thematic content of the AHPRFs to develop a single consolidated framework. Phase three included a workshop with experts to validate and adapt the framework for practice.
Results
19 AHPRFs were identified. A consolidated framework was shaped by content analysis of the AHPRFs resulting in a consolidated framework of eight sections, each containing a series of competencies. Each section relates to an analytic theme within the content analysis, and the competencies were based on analytic sub-categories of themes. The final framework was further shaped by the phase three workshop into a set of ‘stem’ competency statements that can be adapted to reflect different levels of expertise. It also includes a set of guiding principles for use.
Conclusion
The consolidated framework was entitled ‘Shaping Better Practice Through Research: A Practitioner Framework’ by stakeholders, thus emphasising its ambition to embed research activity into practice. It instigates a new perspective within AHP research by offering practitioners and managers a tool that can be applied across public, private and voluntary settings for AHPs in all disciplines. Its ambition is to develop capacity in the AHPs that can undertake research to improve services and the health of service users.
Nasopharyngeal carriage, spa types and drug susceptibility profiles of Staphylococcus aureus from healthy children under 5 years in eastern Uganda
Authors: Kateete David , Asiimwe Benon B , Mayanja Raymond , Mujuni Brian , Bwanga Freddie , Najjuka Christine F , Källander Karin , Rutebemberwa Elizeus 
Published: July 2019

Abstract
Background

Staphylococcus aureus carriage is a known risk factor for staphylococcal disease. However, the carriage rates vary by country, demographic group, etc. This study aimed to determine the S. aureus carriage rate in Ugandan children, and track Staphylococcus strains that can cause infection in Uganda.

Methods

Nasopharyngeal samples (one per child) from 742 healthy children under 5 years living in Iganga/Mayuge Health & Demographic Surveillance Site in eastern Uganda were processed for isolation of S. aureus. Genotyping was performed by spa typing and pulse field gel electrophoresis.

Results

The processed samples yielded 144 S. aureus isolates (one per sample/child) therefore, the S. aureus carriage rate in the children was 19.4% (144/742). Further, 45 (31.3%, 45/144) of the isolates were methicillin resistant (MRSA) yielding a carriage rate of 6.1% (45/742). All MRSA isolates were susceptible to vancomycin, linezolid and clindamycin however, compared to methicillin susceptible S. aureus (MSSA) isolates (68.8%, 99/144), MRSA were more resistant to non-beta-lactam antimicrobials –tetracycline (91.1%, 41/45), trimethoprim/sulfamethoxazole (73.3%, 33/45), erythromycin (75.6%, 34/99), chloramphenicol (60%, 19/99), gentamicin (55.6%, 25/45) and ciprofloxacin (35.6%, 16/45). Furthermore, an MRSA isolate was mupirocin resistant and 42 (93.3%, 42/45) were multidrug resistant (MDR); three (3%, 3/99) MSSA isolates were mupirocin and clindamycin resistant while 61 (61.6%, 61/99) were MDR. All MSSA/MRSA isolates were susceptible to rifampicin, vancomycin and linezolid but only two were pan-susceptible to the tested antibiotics. Seven spa types were detected in MRSA, of which t064 & t037 were predominant and associated with SCCmec types I & IV, respectively. Fourteen spa types were detected in MSSA, of which t645 & t4353 were predominant.

Conclusions

S. aureus (MSSA/MRSA) carriage rate in children in rural eastern Uganda is high and comparable to rates for hospitalized patients in Kampala city. Detection of mupirocin resistance is worrying as it could rapidly increase in a low-income setting should mupirocin be used for staphylococcal decolonization. Further, S. aureus strains of spa types t064, t037, t645 & t4353 are prevalent and could be responsible for majority of staphylococcal infections in Uganda.
Prevalence and Predictors of Computer Vision Syndrome among Secretary Employees working in Jimma University, Southwest Ethiopia: A Cross Sectional Study at Jimma University
Authors: Tesfa Mekonnin , Sadik Mohammed Ibrahim , Markos Yohannes , Aleye Leyla Temam 
Published: July 2019

Abstract
Background

Computer vision syndrome (CVS) is a group of ocular and extra-ocular symptoms experienced in relation to computer use. Nearly 60 million people suffer from CVS globally with a million of new cases occurring each year. The discomfort associated with this disorder result in increased error rate, reduced job satisfaction and work productivity. The problem has become a workplace concern among computer users especially in those occupationally exposed. The magnitude of CVS and its determinants are not well known in Ethiopia. Therefore, the aim of this study was to determine prevalence and predictors of computer vision syndrome among secretaries working in Jimma University, Ethiopia.

Methods

An institution based cross-sectional study was conducted on a total of 217 secretary employees working in Jimma University. An interviewer administered pre-tested structured questionnaire was used to collect data. Collected data was analyzed using SPSS version 20.0. Multivariable logistic regression analysis was done to identify the independent predictors for CVS.

Results

A total of 217 secretaries were included in the study and all of them were females. The prevalence of CVS among study participants was 75.6%. Blurred vision 88(40.6%), extra-ocular symptoms 75(34.6%), eyestrain 66(30.4%) and headache 63(29.0%) were the most commonly reported symptoms of CVS. Factors significantly associated with CVS were duration of occupation (AOR=3.165; 95% CI=1.16, 8.57), average time spent on computer per day (AOR=3.163; 95% CI=1.52, 6.59), computer brightness adjustments (AOR=2.81; 95% CI=1.22, 6.47) and awareness on CVS and its prevention measures (AOR=5.385; 95% CI= 2.55, 11.35).

Conclusion

This study revealed that CVS was highly prevalent among secretary employees working in Jimma University. Duration of occupation, average time spent on computer per day, awareness about CVS and its prevention measures and adjustments of computer brightness were the independent factors associated with computer vision syndrome. Secretaries should aware that CVS is a problem that can be prevented by proper use of computer at work place and therefore a means to increase their awareness should be considered.
A RE-AIM Evaluation of a multi-modal real-world intervention for dementia risk reduction
Authors: Stirling Christine , Merl Helga , Arunachalam Indra , Turner Ashley , King Carolyn 
Published: July 2019

Abstract
Background

This implementation study evaluated a novel community-based Memory Wellness Program targeting dementia risk reduction through increasing health knowledge and health promoting behaviours in older adults. The nurse-led eight-week program involved the following behaviour change strategies: goal-setting, education, group activity, and introduction to the use of iPads and Misfit activity trackers. The multi-model program was delivered in a realworld setting using pop-up clinics run by a Registered Nurse, across 18 different sites.

Methods

Using a quasi-experimental mixed methods design, and a RE-AIM framework, the study evaluated the reach, effectiveness, adoption, implementation and maintenance of the MWP. A total of 179 older adults aged 65 years and over participated in the evaluation across eighteen locations in three states and a territory of Australia. Paired t-tests were carried out on all pretest-posttest clinical data. In-depth interviews were conducted with seventeen participants and staff.

Results

Engagement in the program was associated with improved cognition, lowered BP and stress and increased engagement with technology. There was a trend towards reduced feelings of loneliness. Participants’ main motivations for undertaking the program were to improve memory, meet new people and improve technology use and computer literacy, with most participants reporting that these goals had been met through the program. The program was effective across multiple sites demonstrating it can successfully be implemented in different contexts and that the range of behaviour change techniques suit a useful multi-modal program.

Conclusions

This evaluation of a community-based Memory Wellness Program demonstrated increased cognitive function in older adults presenting with concerns about their cognition and memory. The statistically significant results and medium to large effect sizes suggest that further research is warranted to assess the efficacy of multi-modal community-based programs for improving memory and mental health with a focus on dementia risk reduction in older adults.
The Response of Second Line Chemotherapy Platinum Resistant Ovarian Cancer in Sudan: 2013-2017
Authors: Alshykh Mohammed Altyb , Essa Mohammed Elmujtba Adam , Suleiman Yousra Abdelmoniem , Osman Sherihan Mohammed Elkundi , Haron Mutwaly Defealla Yousif , Hussein Mustafa Mohamed Ali , Abdelrahim Shiemaa Emad , Osman Leena Habeeb Allah , Mohamed Saja Hassan , Rahama Salma Ismaeel , Ali Saneyya Alsir , Abdullahi Sadiya Aminu , Musa Suha Abdallah , Ahmed Abdelkareem A. 
Published: July 2019

Abstract
Background

Ovarian carcinoma is the fifth leading cause of cancer death worldwide. The tumor mostly associated with variant factors such as advance age, early menstruation and gene association. We aimed to highlight the effectiveness of the second line chemotherapy in the management of ovarian cancer patients in Sudan.

Methods

The data were collected from the hospital patient’s records for five years period of time, included 62 patients with ovarian cancer who is treated by the second line platinum resistant chemotherapy.

Result

The peak prevalence of the patients was found in Aljazeera state, and the least in Algadarif state. Age group above 55 years was the most affected group. The vast majority of patients showed partially mass disappearing, completes and continue growing tumor respectively. All patients received variant cycles of chemotherapy as fellow 3, 6, 2, 4, 5, 1 cycle respectively. 79.4% of the patients had achieved the normal value of cancer antigen 125 (CA125) levels after the treatment. 50% of patients had 1-2 months interval time before the cancer recurrence, 32.2% had 3-4 months and 17.8% had 5-6 months before the disease recurrence. The serous adenocarcinoma was found to be the most histological type in all the patients and the least two types were observed are cell carcinoma and serous papillary.

Conclusion

Our findings suggested that, Aljazeera state citizens were more vulnerable to resist the first line chemotherapy than others. The Sudanese patients with ovarian cancer may have better response to Gemzar.
Comparing the safety and efficacy of endovascular treatment versus bypass surgery for infrarenal aortic occlusion: a single-center experience
Authors: Wang Jingjing , Shao Jiang , Qiu Chenyang , Fang Lijing , Li Kang , Lei Jinsong , Xu Leyin , Zhang Xin , Liu Xiu , Lai Zhichao , Liu Bao 
Published: July 2019

Abstract
Background

Infrarenal aortic occlusion (IAO) is a complete occlusion of infrarenal aorta, which is the most complicated and severe subclass of aortoiliac occlusive disease(AIOD). The first-line treatment for IAO is bypass surgery due to its favorable patency rate. As endovascular technique advances, several retrospective studies have reported their endovascular experience for IAO. However, whether endovascular treatment(EVT) is comparable to bypass surgery for IAO required further study. This research was to study the safety and efficacy of EVT for IAO compared to bypass surgery.

Methods

From 2003 to 2017, 44 consecutive patients with IAO was treated with EVT(n=16) or aortofemoral bypass surgery(n=28). The therapeutic strategy depended on patient’s will and state of health. Demographics, comorbidity, mortality, complication rate, and symptom-free survival proportion was compared by T-tests or chi-square test, to illustrate the safety and efficacy of EVT and bypass surgery.

Results

The demographics and pre-operative Rutherford classification equally distributed in the two groups(P>0.05). As for technical success, comorbidities, mortality, complication rate, and Rutherford classification after procedures, clinical success, no significant difference was observed(P>0.05). The median post-procedure hospital stay was 4 days in the EVT group and was significantly shorter than that of the bypass, which was 11 days(P<0.05). As for short-term and long-term results, the 1-year, 3-year, and 5-year the cumulative symptom-free survival rates were 85.7%, 85.7% and 85.7% in the EVT group, 100%, 94.1% and 80.7% in the aortofemoral bypass group. There was no significant difference in symptom-free survival rate between the two groups according to log-rank test (P=0.92)

Conclusions

The safety and efficacy of EVT were comparable to that of anatomic bypass surgery for IAO. EVT could be a feasible option for IAO.
Why are patients discontented after total knee arthroplasty when the orthopedic surgeons are contented?
Authors: Mahdi Aamir , Svantesson Mia , Wretenberg Per , Hälleberg Maria 
Published: July 2019

Abstract
Background

Total knee arthroplasty is a common procedure with generally good results. However, there are still patients who are discontented without known explanation. Contentment and discontentment have previously been captured by quantitative designs, but there is a lack of qualitative studies regarding these patients’ experiences. Qualitative knowledge might be useful in creating strategies to decrease the discontentment rate.

Methods

Of the 348 patients who responded to a letter asking if they were contented or discontented with their surgery, 61 (18%) reported discontentment. After excluding patients with documented complications and those who declined to participate, semi-structured interviews were conducted with 44 patients. The interviews were analyzed according to qualitative content analysis. The purpose was to describe patients’ experiences of discontentment one year after total knee arthroplasty.

Results

The patients experienced unfulfilled expectations and needs regarding unresolved and new problems, limited independence, and need for buttresses. They were bothered by pain and stiffness, and worried that changes were complications as a result of surgery. They described inability to perform daily activities and valued activities. They also felt a need for buttresses, and a lack of respect and continuity, support from health care, and information adapted to their needs.

Conclusion

Patient expectation seems to be the major contributing factor in patient discontentment after knee replacement surgery. This qualitative study sheds light on the meaning of unfulfilled expectations, in contrast to previous quantitative studies. The elements of unfulfilled expectations need to be dealt with both on the individual staff level and on the organizational level. For instance, increased continuity of healthcare staff and facilities may help to improve patient contentment after surgery.
Seeking Resilience: The Care Capacity Goals of Family Carers and the Role of Technology in Achieving Them
Authors: Leslie Myles , Gray Robin Patriccia , Eales Jacquie , Fast Janet , Magnaye Andrew , Khayatzadeh-Mahani Akram 
Published: July 2019

Abstract
Background

As global populations age, governments have come to rely heavily on family carers (FCs) to care for older adults and reduce the demands made of formal health and social care systems. Under increasing pressure, FCs’ resilience and the sustainability of their unpaid care work have become pressing issues. This paper explores FCs’ care-related work goals and how those goals do, or do not, link to technology.

Methods

We employed a sequential mixed-method approach using focus groups followed by an online survey about FCs’ goals. We held 10 focus groups and recruited 25 FCs through a mix of convenience and snowball sampling strategies. Carer organizations helped recruit 599 FCs from across Canada to complete an online survey. Participants’ responses to an open-ended question in the survey were included in our qualitative analysis. An inductive approach was employed using qualitative thematic content analysis methods to examine and interpret the resulting data. We used NVIVO 12 software for data analysis.

Results

We identified two care quality improvement goals of FCs providing care to older adults: enhancing and safeguarding their caregiving capacity. To enhance their capacity to care, FCs sought: 1) foreknowledge about their care recipients’ changing condition, and 2) improved navigation of existing support systems. To safeguard their own wellbeing, and so to preserve their capacity to care, FCs sought to develop coping strategies as well as opportunities for mentorship and socialization.

Conclusions

We conclude that a paradigm shift is needed to reframe caregiving from a current deficit frame focused on limitations (burden of care) towards a more empowering frame (sustainability and resiliency). The fact that FCs are seeking strategies to enhance and safeguard their capacities to provide care means they are approaching their unpaid care work from the perspective of resilience. Their goals and technology suggestions imply a shift from understanding care as a source of ‘burden’ towards a more ‘resilient’ and ‘sustainable’ model of caregiving. Our case study findings show that technology can assist in fostering this resiliency but that it may well be limited to the role of an intermediary that connects FCs to information, supports and peers.
Functional and anatomical characterization of a non-leaking bilateral cystoid macular edema induced by paclitaxel therapy for ovarian cancer: a case report
Authors: Hoffmann Stephan , Ganster David , Sidoroff Patrick , Mennel Stefan 
Published: July 2019

Abstract
Abstract:
Background: Paclitaxel is a member of the taxane family used for cancer therapy. Ovarian cancer is treated with Paclitaxel in first- and in second- line therapy. Cystoid macular edema without fluorescein leakage is a rare side effect of Paclitaxel treatment.
Case presentation: We report the case of a 59-year-old female with ovarian cancer treated with paclitaxel. The patient received 21 cycles of adjuvant chemotherapy and was presented with bilateral gradual vision loss due to macular edema after paclitaxel treatment. Optical coherence tomography revealed a bilateral cystoid macular edema. Fluorescence angiography demonstrated the unusual finding of non-leakage in the late phases of the angiogram. Microperimetric findings of both eyes confirmed the visual deficits. After cessation of the paclitaxel therapy, vision, OCT and microperimetric findings returned to normal. Also, color vision testing demonstrated no persistent defect after therapy cessation.
Conclusion: Paclitaxel induced bilateral maculopathy is a rare side effect of chemotherapy. Cessation of the Paclitaxel drug therapy leads to complete functional and anatomical resolution of drug induced side effects. Vision, microperimetric defects, color perception as also anatomical defects detected by OCT change to normal after drug cessation.
Taxane induced bilateral maculopathy is a rare disease which should be known by ophthalmologists as also oncologists. Paclitaxel therapy must be counseled to report any vision problems during the treatment period because early recognition of a rare non leaking CME can facilitate appropriate intervention to reverse visual compromise and minimize any potential long-term ophthalmologic sequelae.
Design, In Silico Modelling, and Functionality Theory of Novel Folate Receptor Targeted Rutin Encapsulated Folic Acid Conjugated Keratin Nanoparticles for Effective Cancer Treatment
Authors: Kunjiappan Selvaraj , Panneerselvam Theivendren , Govindaraj Saravanan , Parasuraman Pavadai , Baskararaj Suraj , Sankaranarayanan Murugesan , Arunachalam Sankarganesh , Babkiewicz Ewa , Jeyakumar Aarthi , Lakshmanan Muthulakshmi 
Published: July 2019

Objective:
Site-specific and toxic-free drug delivery, is an interesting area of research. Nanoengineered
drug delivery systems possess a remarkable potential for effective treatment of various types of
cancers.

Methods:
In this study, novel Folic Acid (FA) conjugated keratin nanoparticles (NPs) were assembled with
encapsulation and delivery of Rutin (Rt) into breast cancer cells through the overexpressed folate receptor. The
biocompatible, Rt encapsulated FA conjugated keratin NPs (FA@Ker NPs) were successfully formulated by a
modified precipitation technique. Their morphological shape and size, size distribution, stability, and physical
nature were characterized and confirmed. The drug (Rt) encapsulation efficiency, loading capacity and release
kinetics were also studied.

Results:
The observed results of molecular docking and density functionality theory of active drug (Rt) showed
a strong interaction and non-covalent binding of the folate receptor and facilitation of endocytosis in breast
cancer cells. Further, in vitro cytotoxic effect of FA@Ker NPs was screened against MCF-7 cancer cells, at 55.2
µg/mL of NPs and found to display 50% of cell death at 24h. Moreover, the NPs enhanced the uptake of Rt in
MCF-7 cells, and the apoptotic effect of condensed nuclei and distorted membrane bodies was observed. Also,
NPs entered into the mitochondria of MCF-7 cells and significantly increased the level of ROS which led to cell
death.

Conclusion:
The developed FA@Ker NPs might be a promising way to enhance anti-cancer activity without
disturbing normal healthy cells.