bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACP5: Its Structure, Distribution, Regulation and Novel Functions
Authors: Ren Xin , Shan Wen-Hua , Wei Lu-Lu , Gong Chan-Chan , Pei Dong-Sheng 
Published: April 2018

Background:
Tartrate-resistant acid phosphatase 5 (ACP5) is an evolutionarily conserved and multifunctional
protein that is involved in generations of reactive oxygen species, normal bone development, osteoblast
regulation and macrophage function, affecting a series of pathways, as well as reflecting bone resorption
and osteoclast activity.

Methods:
Literature searches, systematic reviews and assessments about the structure, distribution, regulation
and novel functions of ACP5 were performed in this review from PubMed and Medline databases.

Results:
Studies demonstrate that RANKL can increase the expression of ACP5 through NFATc1 and c-Fos to
accelerate osteoclastogenesis, which also can be regulated by many regulators. Based on the aforementioned
information, it is shown that ACP5, together with the phosphatase activity, can medicate the progression and
development of human genetic diseases and cancer.

Conclusion:
As a novel target, ACP5 plays a critical role in preventing, monitoring and treating various kinds of
tumors, as well as accelerating the development of a promising therapeutic strategy for human genetic diseases.
However, the explicit mechanism between ACP5 and cancer is not so clear. It is necessary and significant for us
to pay more in-depth attention.
CoCrMo alloy vs. UHMWPE Particulate Implant Debris Induces Sex Dependent Aseptic Osteolysis Responses In Vivo using a Murine Model
Authors: Landgraeber Stefan , Samelko Lauryn , McAllister Kyron , Putz Sebastian , Jacobs Joshua.J. , Hallab Nadim James 
Published: April 2018

Background:The rate of revision for some designs of total hip replacements due to idiopathic aseptic loosening has been reported as higher for women. However, whether this is environmental or inherently sex-related is not clear.Objective:Can particle induced osteolysis be sex dependent? And if so, is this dependent on the type of implant debris (e.g. metalvspolymer)? The objective of this study was to test for material dependent inflammatory osteolysis that may be linked to sex using CoCrMo and implant grade conventional polyethylene (UHMWPE), using anin vivomurine calvaria model.Methods:Healthy 12 week old female and male C57BL/6J mice were treated with UHMWPE (1.0um ECD) or CoCrMo particles (0.9um ECD) or received sham surgery. Bone resorption was assessed by micro-computed tomography, histology and histomorphometry on day 12 post challenge.Results:Female mice that received CoCrMo particles showed significantly more inflammatory osteolysis and bone destruction compared to the females who received UHMWPE implant debris. Moreover, females challenged with CoCrMo particles exhibited 120% more inflammatory bone loss compared to males (p<0.01) challenged with CoCrMo implant debris (but this was not the case for UHMWPE particles).Conclusion:We demonstrated sex-specific differences in the amount of osteolysis resulting from CoCrMo particle challenge. This suggests osteo-immune responses to metal debris are preferentially higher in female compared to male mice, and supports the contention that there may be inherent sex related susceptibility to some types of implant debris.
Progressive Assessment of Ischemic Injury to White Matter Using Diffusion Tensor Imaging: A Preliminary Study of a Macaque Model of Stroke
Authors: Zhang Xiaodong , Yan Yumei , Tong Frank , Li Chun-Xia , Jones Benjamin , Wang Silun , Meng Yuguang , Muly E. Chris , Kempf Doty , Howell Leonard 
Published: April 2018

Background:
Previous Diffusion Tensor Imaging (DTI) studies have demonstrated the temporal evolution of stroke injury in grey matter and white matter can be characterized by DTI indices. However, it still remains not fully understood how the DTI indices of white matter are altered progressively during the hyperacute (first 6 hours) and acute stage of stroke (≤ 1 week). In the present study, DTI was employed to characterize the temporal evolution of infarction and white matter injury after stroke insult using a macaque model with permanent ischemic occlusion.

Methods and materials:
Permanent middle cerebral artery (MCA) occlusion was induced in rhesus monkeys (n=4, 10-21 years old). The brain lesion was examined longitudinally with DTI during the hyperacute phase (2-6 hours, n=4), 48 hours (n=4) and 96 hours (n=3) post-occlusion.

Results:
Cortical infarction was seen in all animals. The Mean Diffusivity (MD) in lesion regions decreased substantially at the first time point (2 hours post stroke) (35%, p <0.05, compared to the contralateral side) and became pseudo-normalized at 96 hours. In contrast, evident FA reduction was seen at 48 hours (39%, p <0.10) post-stroke. MD reduction in white matter bundles of the lesion area was much less than that in the grey matter during the hyper-acute phase but significant change was observed 4 hours (4.2%, p < 0.05) post stroke . Also, MD pseudonormalisation was seen at 96 hours post stroke. There was a significant correlation between the temporal changes of MD in white matter bundles and those in whole lesion areas during the entire study period. Meanwhile, no obvious fractional anisotropy (FA) changes were seen during the hyper-acute phase in either the entire infarct region or white matter bundles. Significant FA alteration was observed in entire lesion areas and injured white matter bundles 48 and 96 hours post stroke. The stroke lesion in grey matter and white matter was validated by pathological findings.

Conclusion:

The temporal evolution of ischemic injury to the grey matter and white matter from 2 to 96 hours after stroke onset was characterized using a macaque model and DTI. Progressive MD changes in white matter bundles are seen from hyperacute phase to acute phase after permanent MCA occlusion and temporally correlated with the MD changes in entire infarction regions. MD reduction in white matter bundles is mild in comparison with that in the grey matter but significant and progressive, indicating it may be useful to detect early white matter degeneration after stroke.
Aplicación de una escala de visualización de la mucosa gástrica, durante la esofagogastroduodenoscopia en pacientes premedicados con N-acetilcisteína más simeticona: experiencia en Ocaña, Norte de Santander
Authors: Royero Gutiérrez Henry Alberto 
Published: April 2018

Introducción: La visibilidad de la mucosa gástrica puede verse limitada por el moco adherente y la formación de burbujas durante la endoscopia de vías digestivas altas. Objetivos: Conocer los puntajes de visualización de la mucosa gástrica y el número de lavados para aclarar la superficie gástrica de burbujas y espumas, aplicando la escala modificada de Kuo en pacientes premedicados antes de la esofagogastroduodenoscopia.Materiales y métodos: estudio descriptivo, prospectivo, fueron incluidos 120 pacientes entre octubre y diciembre de 2016, a los cuales se les premedicó con N-acetilcisteina al 4 %, 400 mg (10cc) más Simeticona (Dimetilpolisiloxano) 133,3 mg (2cc) y agua tibia 100 cc, 20 minutos antes del procedimiento, los datos fueron tabulados en Excel y posteriormente sus frecuencias y porcentajes analizados por el paquete estadístico Epiinfo. CDC (versión 7,2 para Windows. USA), se consideró significancia estadística una p < 0.05. Resultados: la puntuación total de visibilidad de la mucosa gástrica considerada como optima con un puntaje de 4 fue 57 (47,50%); con 5 puntos fueron 36 (30 %), con 6 y 7 puntos 10 (8,33%); con 6 puntos 8 (5%), y por ultimo con 9 puntos 1 (0,83%); no hubo casos en las puntuaciones de 10 a 16. 99 (82,5%), pacientes no necesitaron lavados adicionales con agua para visualizar la mucosa gástrica contra 15 (12,50%) que requirieron menos de 50 cc y 6 (5%) que necesitaron más de 50 cc (p=0,00). Limitaciones: fue realizado por un solo observador lo que pudo generar sesgos de detección además, la muestra es pequeña. Conclusiones: Con la administración de una solución de N-acetilcisteina más Simeticona diluidas en 100 cc de agua tibia, previa a la endoscopia de vías digestivas altas se obtuvo una visualización optima de la mucosa gástrica en la mayoría de los casos y se observó la necesidad de un menor volumen de agua para aclarar la cavidad gástrica de moco y espuma.
IMPROVED STUDENT LEARNING ACTIVITIES AND OUTCOME USING TALKING STICK METHOD
Authors: Primawati Primawati , Ambiyar Ambiyar , Ramadhani Devia 
Published: April 2018

In learning process basic mechanical engineering is seen that students tend to be passive, as hearers only, reluctant to express opinions. The purpose of research study is to explore effectiveness of talking stick method in learning process in mechanical engineering in SMK Muhammadiyah 1 Padang. Students of class X has been selected as the research subject. Observation sheets used to collect data on learning activity process and objective test used to know learning outcome of this method. Research conducted in two cycles. The result in cycle 1, the value of learning activity is 62.2% and 81.03% in cycle 2. The value of clasical completeness 61.90% in cycle 1 and 76.19% in cycle 2. Th average of learning outome in cycle 1 is 75.54 and 84.04 in cycle 2.
PENGARUH KEPRIBADIAN TERHADAP WORK ENGAGEMENT (The Influence Of Personality To Work Engagement)
Authors: Zamralita Zamralita 
Published: April 2018

AbstrakPenelitian ini membahas mengenai profil kepribadian dan work engagement pada dosen tetap. Tujuan penelitian ini untuk mengetahui pengaruh kepribadian terhadap work engagement. Selanjutnya juga diuji pengaruh setiap trait kepribadian terhadap work engagement. Partisipan penelitian adalah dosen tetap dari 5 (lima) universitas swasta terbaik di Indonesia yang berjumlah 602 (enam ratus dua) orang. Data penelitian diperoleh melalui kuesioner kepribadian dan kuesioner work engagement. Analisis data menggunakan Metode Structural Equation Modeling. Hasil penelitian membuktikan dosen memiliki profil kepribadian trait openness to experience tinggi, trait conscientiousness tinggi, trait extraversion tinggi, trait agreeableness tinggi, dan trait neuroticism yang rendah. Selain itu trait openness to experience, trait conscientiousness, trait extraversion, trait agreeableness, trait neuroticism berpengaruh terhadap work engagement. Kesimpulan dari penelitian ini profesi dosen memiliki profil kepribadian yang khas dengan trait agreeableness yang lebih menonjol dibandingkan trait lain dan membuktikan seluruh trait kepribadian berpengaruh terhadap work engagement pada profesi dosen. Kata kunci: Kepribadian, work engagement, dosen tetap, universitas swastaAbstractThis study discusses about personality profile and work engagement on full time lecturers. Purpose of this study was to examine the influence of personality traits on work engagement. Furthermore also tested the influence of each personality trait to work engagement. The participants were 602 full time lecturers from the best five private universities in Indonesia. Data were obtained through personality and work engagement questionnaires. Methods of data analysis using structural equation modelling. The results are lecturer profession has high score in openness to experience trait, conscientiousness trait, extraversion trait, agreeableness trait, and low score in neuroticism trait. Furthermore all personality traits influenced work engagement. The conclusion of this research are lecturer profession has a distinctive personality profile with the agreeableness trait that is more prominent than others and prove all personality traits as predictor work engagement.Keywords: Personality, Work Engagement, Lecturer, Private university
EFEKTIVITAS ANTIJAMUR KOMBINASI KETOKONAZOL DENGAN MINYAK ATSIRI SEREH WANGI (Cymbopogon nardus (L.) Rendle)
Authors: Lely Nilda , Pratiwi Reni Indah , Imanda Yunita Listiani Imanda Listiani 
Published: April 2018

AbstrakMinyak atsiri merupakan salah satu senyawa kimia dalam tanaman yang terbukti berpotensi sebagai antijamur. Beberapa penelitian menunjukkan bahwa minyak atsiri sereh wangi (Cymbopogon nardus L. Rendle) mempunyai aktivitas terhadap jamur patogen Tricophyton rubrum, Microsporum canis, dan Epidermophyton floccosum yang dapat menyebabkan penyakit dermatofitosis. Antijamur yang digunakan untuk pengobatan dermatofitosis ini, salah satunya adalah ketokonazol yang merupakan antijamur golongan imidazol. Pada penelitian ini ditentukan efektivitas antijamur kombinasi ketokonazol dengan minyak atsiri sereh wangi terhadap jamur penyebab dermatofitosis. Ekstraksi minyak atsiri menggunakan metode destilasi uap air. Uji efektivitas antijamur kombinasi ketokonazol dengan minyak atsiriri sereh wangi dengan metode difusi agar. Hasil penelitian kombinasi ketokonazol dengan minyak atsiri menunjukkan efek sinergis, karena diameter zona hambat ketokonazol mengalami peningkatan setelah dikombinasikan dengan minyak atsiri. Diameter zona hambat ketokonazol tunggal Tricophyton rubrum ATCC 28188 13,26 mm setelah dikombinasikan menjadi 24,9 mm, Microsporum canis ATCC 32699 12,8 mm setelah dikombinasikan menjadi 22,56 mm, Epidermophyton floccosum ATCC 52066 12,76 mm setelah dikombinasikan menjadi 19,5 mm. Hal ini disebabkan karena mekanisme kerja yang sinergis dari minyak atsiri sereh wangi (Cymbopogon nardus L. Rendle) dan ketokonazol.Kata kunci: citronella, dermatofitosis, sinergisAbstractEssential oil is one of the chemical compounds in plants that have been proven potential as an antifungal agent. Some studies showed that the essential oil of citronella (Cymbopogon nardus L. Rendle) could resist fungal pathogens Tricophyton rubrum, Microsporum canis and Epidermophyton floccosum, which cause dermatophytosis. Antifungals used for the treatment of dermatophytosis is ketoconazole, which belongs to imidazole group. The purpose of this study was to determine the effectiveness of antifungal ketoconazole in combination with essential oils of citronella against dermatophytosis. Extraction of essential oils was carried out using steam distillation. The effectiveness of antifungal ketoconazole in combination with citronella oil was measured using disk diffusion method. The result of the combination of ketoconazole with essential oils was synergistic as proven by the increased diameter of inhibition zone ketoconazole after combined with essential oils. Ketoconazole inhibition zone diameter single Tricophyton rubrum ATCC 28188 13.26 mm after combined into a 24.9 mm, Microsporum canis ATCC 32699 12.8 mm after combined into a 22.56 mm, Epidermophyton floccosum ATCC 52066 12.76 mm after combined into 19, 5 mm. This is because the synergitic mechanism of action of essential oils of citronella (Cymbopogon nardus L. Rendle) and ketoconazole.Key words: citronella, dermatophytosis, synergistic
Aplicación de métodos estadísticos multivariables para La evaluación de la calidad del agua en Arroyo Plata, Caribe colombiano
Authors: Baldiris Idelffonso , Sanchez Aponte Jorge Hernan 
Published: April 2018

<p>Arroyo Plata es una ramificación del dique canal del Río Magdalena, que desemboca en el Mar Caribe, cerca de Cartagena, y que descarga contaminantes que influyen en la calidad del agua. Los datos ambientales se analizaron mediante pruebas de hipótesis e intervalos de confianza y también utilizando métodos estadísticos multivariados, incluida la correlación de Pearson y análisis de componentes principales (PCA). La demanda bioquímica de oxigeno (DBO5), Temperatura, Fósforo y salinidad están fuera del rango recomendado para la buena salud de la flora y fauna marina. Se identificaron cuatro factores como responsables de la estructura de datos, lo que explica el 65,66% de la varianza total. El primer factor son los parámetros químicos físicos y no orgánicos que explican el 20,22% de la varianza total. El segundo y el tercer factor son, respectivamente, el microbiológico (18%) y fisicoquímico (16.2%) y el cuarto factor, el agroindustrial explica el 11,54%. Este estudio muestra que los métodos estadísticos multivariados pueden ayudar a los administradores del recurso a comprender los factores que afectan la calidad del agua.</p>
ANALISIS KARAKTERISTIK DIKLAT TEKNIS SDM PENYELENGGARA UNIT PENIMBANGAN KENDARAAN BERMOTOR DI PROVINSI JAWA TENGAH
Authors: Arianto Setio Boedi , Heriwibowo Dwi 
Published: April 2018

Tujuan penelitian ini adalah untuk mengetahui karakteristik diklat SDM penyelenggara unit penimbangan kendaraan bermotor di Provinsi Jawa Tengah, dengan menggunakan metode Analisis Deskriptif Kualitatif dan Kuantitatif maka kesimpulan penelitian ini adalah karakteristik responden di Provinsi Jawa Tengah berdasarkan usia yang lebih dominan adalah responden yang berusia > 50 tahun berjumlah 34 orang, berpendidikan SMA/Sederajat sebanyak 39 orang, dan jabatan responden yang dominan adalah sebagai Pengatur Lalu Lintas berjumlah 19 orang. Jumlah personil Unit Penyelenggara Penimbangan Kendaraan Bermotor (UPPKB) di Provinsi Jawa Tengah sebanyak 265 orang, 60% telah mengikuti diklat teknis dan 40% tidak mengikuti diklat teknis. Berdasarkan jumlah personil yang telah mengikuti diklat teknis (160 orang), personil yang mengikuti diklat teknis operator jembatan timbang sebesar 24%, sedangkan 76% tidak mengikuti diklat teknis operator jembatan timbang. Personil yang mengikuti diklat teknis penimbangan kendaraan bermotor sebesar 31%, sedangkan 69% tidak mengikuti diklat teknis penimbangan kendaraan bermotor. Personil yang mengikuti diklat teknis PPNS sebesar 20%, sedangkan 80% tidak mengikuti diklat teknis PPNS. Personil yang mengikuti diklat teknis transportasi dan lalu lintas sebesar 45%, sedangkan 55% tidak mengikuti diklat teknis transportasi dan lalu lintas. Personil yang mengikuti diklat teknis andalalin hanya 1%, sedangkan 99% tidak mengikuti diklat teknis andalalin. Personil yang mengikuti diklat teknik informatika/komputer sebesar 1%, sedangkan 99% tidak mengikuti diklat teknik informatika/komputer.
Hands-On Experiments in the Interactive Physics Laboratory: Students’ Intrinsic Motivation and Understanding
Authors: Snětinová Marie , Kácovský Petr , Machalická Jana 
Published: April 2018

Experiments in different forms can certainly be suitable tools for increasing student interest in physics. However, educators continuously discuss which forms of experimenting (if any) are the most beneficial for these purposes. At the Faculty of Mathematics and Physics, Charles University, Prague, two different forms of physics experiments are offered to upper secondary students: hands-on experimental work in the InteractivePhysics Laboratory, and physics demonstration shows where the students watch experiments conducted by a lecturer. Our research focuses primarily on student feedback about their immediate attitudes towards these two projects. Data collection was undertaken using questionnaire research based on the Intrinsic Motivation Inventory. This research was subsequently supplemented with a qualitative study examining the influenceof students’ experimental work in the Interactive Physics Laboratory on their understanding of selected physics concepts. The results of the main research show that the two projects do not exhibit significant differencesin terms of student interest and perceived usefulness; nevertheless, students felt the need for significantly more effort and experienced pressure during their work in the Interactive Physics Laboratory. One interestingfinding, which goes against our original hypothesis, is that grades in physics are quite a strong predictor of students’ assessment of the projects: better grades indicate more positive assessment of both projects as well as less pressure felt during hands-on activities in the laboratory.
TEKNOLOGI PROSES BIO OIL DARI MIKROALGA SEBAGAI ENERGI ALTERNATIF
Authors: Uzwatania Fina 
Published: April 2018

Seiring dengan perkembangan peradaban manusia, tingkat kebutuhan energi manusia juga semakin meningkat. Pemenuhan energi di dunia sebagian besar dihasilkan dari pembakaran bahan bakar fosil yang sudah berumur jutaan tahun berupa bahan yang tidak dapat diperbaharui, dan hanya sebagian kecil yang berasal dari penggunaan sumber energi lain yang berasal dari bahan terbarukan. Salah satu contoh energi terbarukan yang dapat dikembangkan diantaranya adalah energi biomassa dari mikroalga sebagai bahan baku alternatif penghasil bio oil. Bio oil merupakan salah satu energi alternatif yang potensial dan belum banyak dikembangkan terutama di Indonesia. Produksi bio oil dapat menghasilkan keuntungan karena konversi bio oil akan menghasilkan beberapa produk berupa bahan bakar, misalnya: biokerosene, biodiesel, arang, gas dan lain sebagainya. Teknologi proses untuk memproduksi bio oil dari mikroalga dimulai dari proses kultivasi, pemanenan, pengeringan dan pirolisis. Pirolisis merupakan penguraian biomassa karena panas pada suhu lebih dari 150 ºC. Hasil proses pirolisis ini berupa cairan, gas, dan padatan.
KERIPIK SIMULASI EKSTRAK DAUN CINCAU HIJAU (Premna oblongifolia Merr.,)
Authors: Loka Hendri Hendra 
Published: April 2018

Daun Cincau sering dimanfaatkan menjadi aneka minuman. Untuk menambah jenis olahan pangan berbahan baku daun cincau ini dilakukan pembuatan keripik simulasi ekstrak daun cincau. Tujuan penelitian ini adalah mengetahui pengaruh perbandingan ekstrak daun cincau, tapioka dan terigu pada pembuatan keripik simulasi ekstrak daun cincau hijau, mengetahui formulasi keripik simulasi ekstrak daun cincau hijau dan mengetahui kandungan zat gizi, jumlah kalori dan kandungan antioksidan produk terpilih. Keripik simulasi ini dibuat dengan empat perbandingan (Ekstrak Daun cincau hijau : Tepung Tapioka : Tepung Terigu) yaitu 0:40:30, 30:40:30, 35:35:40, 40:30:30 dengan dua kali ulangan. Analisis yang dilakukan meliputi organoleptik (uji mutu sensori dan rating hedonik), uji kandungan antioksidan, dan nilai gizi untuk keripik simulasi terpilih. Perbandingan ekstrak daun cincau hijau, tapioka dan terigu pada keripik simulasi ekstrak daun cincau hijau berpengaruh terhadap sifat organoleptik keripik simulasi. Keripik Simulasi ekstrak daun cincau hijau yang terpilih adalah keripik simulasi pada formula A4 (40:30:30), memiliki kadar air 1,78 %, abu 1,78 %, lemak 10,68%, protein 9,08%, karbohidrat 76,67% , nilai energi 439,12 Kkal /100g sampel dan antioksidan 25,1 mg vit C / 100g sampel.
Impact of Shock Front Rippling and Self-reformation on the Electron Dynamics at Low-Mach-number Shocks
Authors: Yang Zhongwei , Lu Quanming , Liu Ying D. , Wang Rui 
Published: April 2018

Abstract
Electron dynamics at low-Mach-number collisionless shocks are investigated by using two-dimensional electromagnetic particle-in-cell simulations with various shock normal angles. We found: (1) The reflected ions and incident electrons at the shock front provide an effective mechanism for the quasi-electrostatic wave generation due to the charge-separation. A fraction of incident electrons can be effectively trapped and accelerated at the leading edge of the shock foot. (2) At quasi-perpendicular shocks, the electron trapping and reflection is nonuniform due to the shock rippling along the shock surface and is more likely to take place at some locations accompanied by intense reflected ion-beams. The electron trapping process has a periodical evolution over time due to the shock front self-reformation, which is controlled by ion dynamics. Thus, this is a cross-scale coupling phenomenon. (3) At quasi-parallel shocks, reflected ions can travel far back upstream. Consequently, quasi-electrostatic waves can be excited in the shock transition and the foreshock region. The electron trajectory analysis shows these waves can trap electrons at the foot region and reflect a fraction of them far back upstream. Simulation runs in this paper indicate that the micro-turbulence at the shock foot can provide a possible scenario for producing the reflected electron beam, which is a basic condition for the type II radio burst emission at low-Mach-number interplanetary shocks driven by Coronal Mass Ejections (CMEs).