bluuebunny/crossref_metadata_2025_split huggingface dataset:
Commentary: the internet, social media, relationships and sex
Authors: Thompson David 
Published: February 2019

Purpose
The purpose of this paper is to use Bates’ paper as a springboard to consider the potential impact of the internet on the personal and intimate lives of people with learning disabilities including opportunities to gain support.

Design/methodology/approach
Key literature is reviewed alongside the author’s experiences in working with people with learning disabilities on sexual issues.

Findings
The literature prioritises internet safety for people with learning disabilities. There is limited attention to how people can be supported to use social media to enhance their social and/or sexual lives.

Originality/value
The commentary challenges the reader to consider how the internet and social media can be used to help people with learning disabilities develop and maintain relationships including sexual relationships.
Vertical–vertical controlled‐source electromagnetic instrumentation and acquisition
Authors: Helwig Stefan L. , Wood William , Gloux Bernard 
Published: February 2019

ABSTRACTVertical–vertical controlled‐source electromagnetic is an alternative to other techniques for providing three‐dimensional resistivity images of the subsurface. It utilizes a large and powerful vertical dipole transmitter and arrays of E‐field receivers with vertical and horizontal dipole sensors. The necessary instrumentation and acquisition procedures which differ strongly from other controlled‐source electromagnetic methods are described in the paper.
Routes to achieving sustainable intensification in simulated dairy farms: The importance of production efficiency and complimentary land uses
Authors: White Patrick J. C. , Lee Mark A. , Roberts Dave J. , Cole Lorna J. 
Published: February 2019

Abstract

Sustainable intensification (SI) is a global challenge, aiming to increase food production whilst conserving biodiversity and ecosystem services. This is contrary to the observed trend of agricultural intensification degrading environmental quality. We developed a framework integrating animal nutrition, crop yields and biodiversity modelling to explore SI potential in multiple model dairy farming systems through varying crop composition to provide cattle feed rations. We then identified key drivers of biodiversity gain that may be applicable at a wider scale.

We developed multiple feed rations to meet the nutritional demands of a high‐yielding, housed dairy herd. The land area required varied due to productivity and nutritional differences between crops, generating spare land. We used published biodiversity models to compare alpha‐ and beta‐diversity of spiders and plants across 36 scenarios that used the spare land in different ways, for either biodiversity maximisation or additional production.

Alpha and beta‐diversity for both taxa was the greatest in scenarios that maximised spare land and utilised this for species‐rich extensive grassland. However, commensurate biodiversity gains for plant alpha‐diversity, and spider and plant beta‐diversity (respectively 100%, 76% and 86% gain relative to that optimal scenario) were achievable when spare land was used for additional crop production.

Maximising compositional heterogeneity and adding complementary productive land uses to spared land were key to increasing production and beta diversity, while adding species‐rich productive land uses drove increasing production and alpha diversity.

Synthesis and applications. This study indicates the potential for the sustainable intensification of dairy farming systems through the manipulation of feed rations to increase land efficiency and spare land, which could then be used to enhance production and biodiversity. The optimum land composition depends on target goal(s) (e.g. maximising production and/or biodiversity). The greatest ‘win‐wins’ can be achieved by making land cover more diverse and selecting crops that complement each other in the species they support; highlighting the important role of heterogeneity in the crop matrix. Our study provides a framework that integrates agricultural production efficiency and biodiversity modelling to explore potential routes to achieve sustainable intensification goals.
Review article: Non‐fatal strangulation: Hidden injuries, hidden risks
Authors: De Boos Julia 
Published: February 2019

AbstractNon‐fatal strangulation (NFS) can be a cause of severe injury. However, the prevalence and rates of injuries from NFS are unknown, as few victims present to medical attention after strangulation. As up to 40% of fatal strangulations have no external signs, and the majority of surviving victims have few or minor injuries, finding those people severely injured remains challenging. The majority of the evidence regarding NFS is largely based on case reports and case series with no robust studies estimating rates of injuries or the best investigation tools. The injuries that are reported make clear that strangulation is a potentially lethal form of injury that should not be ignored in those presenting having been strangled, or in those presenting with neurological symptoms, including strokes, seizures and vascular abnormalities. The safety implications of strangulation are also important as it can be a prelude to homicide. A search of the literature was carried out with the following terms: Nonfatal strangulation (10), Nonfatal strangulation (17), ‘Strangulation injuries’ (19), ‘Manual strangulation’ (92) – laboratory testing eliminated, and ‘choking game’. The PubMed database was used first, followed by the collections of Monash University and the Strangulation Institute (as some articles were too old to find electronically). This article summarises the injuries that can occur following strangulation and discusses the quality of the evidence thus far.
Role of glucocorticoids on noradrenergic and dopaminergic neurotransmission within the basolateral amygdala and dentate gyrus during morphine withdrawal place aversion
Authors: García‐Pérez Daniel , Milanés Maria Victoria 
Published: February 2019

AbstractAversive memories related to drug withdrawal can generate a motivational state leading to compulsive drug taking. However, the mechanisms underlying the generation of these withdrawal memories remain unclear. Limbic structures, such as the basolateral amygdala (BLA) and the dentate gyrus (DG) of the hippocampus, play a crucial role in the negative affective component of morphine withdrawal. Given the prominent role of glucocorticoids (GCs), noradrenaline (NA), and dopamine (DA) in memory‐related processes, in the present study, we employed the conditioned place aversion (CPA) paradigm to uncover the role of GCs on NA and DA neurotransmission within the BLA and NA neurotransmission within the DG during opiate‐withdrawal conditioning (memory formation consolidation), and after reexposure to the conditioned environment (memory retrieval). We observed that adrenalectomy impaired naloxone‐induced CPA. Memory retrieval was associated with an increase in dihydroxyphenylacetic acid (DOPAC) levels in the BLA in morphine‐addicted animals in a GC‐independent manner. Importantly, NA turnover was related with the expression of withdrawal physical signs during the conditioning phase and with locomotor activity during the test phase. On the other hand, reduced DA concentration in the BLA was correlated with the CPA score. Our results indicate that while noradrenergic system is more associated with the somatic consequences of withdrawal, dopaminergic neurotransmission modulates the affective state. Nevertheless, it seems necessary that both systems work together with GCs to enable aversive‐memory formation and recall.
Posterior sampling in two classes of multivariate fractionally integrated models: corrigendum to Ravishanker, N. and B. K. Ray (1997) Australian Journal of Statistics 39 (3), 295–311
Authors: Doppelt Ross , O'Hara Keith 
Published: February 2019

SummaryWe discuss posterior sampling for two distinct multivariate generalisations of the univariate autoregressive integrated moving average (ARIMA) model with fractional integration. The existing approach to Bayesian estimation, introduced by Ravishanker & Ray, claims to provide a posterior‐sampling algorithm for fractionally integrated vector autoregressive moving averages (FIVARMAs). We show that this algorithm produces posterior draws for vector autoregressive fractionally integrated moving averages (VARFIMAs), a model of independent interest that has not previously received attention in the Bayesian literature.
School performance is age appropriate with support services in very preterm children at 11 years of age
Authors: Nyman Anna , Korhonen Tapio , Lehtonen Liisa , Haataja Leena ,   on behalf of the PIPARI Study Group
Published: February 2019

AbstractAimThis Finnish regional birth‐cohort study compared the school performance of very preterm and full‐term children when they reached 11 years of age.MethodsTeachers rated the educational abilities of 123 preterm children and 133 full‐term controls at the age of 11 years as well as the support services they received. The children were all born in the Turku University Hospital between 2001 and 2005. In the preterm group, neurosensory impairments were confirmed at two years of corrected age, and full‐scale intelligence quotient (IQ) was assessed at 11 years of age using the Wechsler Intelligence Scale, Fourth Edition.ResultsEducational abilities, including academic skills and classroom functioning, did not differ between the two groups after excluding the children with a full‐scale IQ < 70. However, 40% of the preterm group and 26% of the controls had received at least one support service (p <0.02). The 13 preterm children with a full‐scale IQ <70 and the 10 with neurosensory impairment received more support services. Boys in both groups displayed more classroom‐functioning problems than girls.ConclusionA full‐scale IQ ≥ 70 and age‐appropriate educational abilities do not exclude a significant need for support services in very preterm children at the age of 11 years.
Optimised infliximab monotherapy is as effective as optimised combination therapy, but is associated with higher drug consumption in inflammatory bowel disease
Authors: Drobne David , Kurent Tina , Golob Saša , Švegl Polona , Rajar Polona , Hanžel Jurij , Koželj Matic , Novak Gregor , Smrekar Nataša , Ferkolj Ivan , Štabuc Borut 
Published: February 2019

SummaryBackgroundCombination treatment with azathioprine for 6‐12 months is the preferred strategy for starting infliximab due to improved pharmacokinetics. However, optimised infliximab monotherapy with proactive dose escalations in case of low trough levels is a safer but under‐studied alternative.AimTo compare the clinical success and infliximab consumption of combination vs optimised monotherapy strategies.MethodsWe studied the clinical success and infliximab consumption of both strategies in 149 patients (94 Crohn's disease; 55 ulcerative colitis) starting infliximab and undergoing intensive drug monitoring assisted treatment optimisation.ResultsThe drug retention rates were similar for optimised monotherapy and combination treatment after induction (96% vs 97%, P = 0.73), after the first year (90% vs 83%, P = 0.23) and at the end of follow‐up (74% vs 75%, P = 0.968). Similarly, no differences were observed for steroid use at year 1 (5% vs 14%, P = 0.08) or mucosal healing at the end of follow‐up (64% vs 67%, P = 0.8). Higher infliximab consumption (7.6 mg/kg q8 weeks [interquartile range (IQR): 5.9‐10.3] vs 6.4 mg/kg q8 weeks [IQR: 5.2‐8.0], P = 0.019) combined with lower trough levels (1.7 µg/mL [IQR: 0.3‐6.6] vs 5.0 µg/mL [2.5‐8.7], P = 0.012) resulted in almost 3‐fold higher drug‐to‐trough ratio (3.9 vs 1.5) in monotherapy compared to combination strategy at year 1. At the end of follow‐up, when azathioprine had been discontinued for a median of 14 [IQR: 3‐33] months, these differences disappeared.ConclusionsIn this study, optimised infliximab monotherapy was as clinically effective as combination therapy but was associated with significantly higher infliximab consumption. The infliximab‐sparing effect disappeared after azathioprine withdrawal.
Safety of elective laparoscopic cholecystectomy in patients with antiplatelet therapy: Lessons from more than 800 operations in a single tertiary referral institution
Authors: Sakamoto Yusuke , Fujikawa Takahisa , Kawamura Yuichiro 
Published: February 2019

IntroductionThe perioperative antiplatelet management of patients receiving antiplatelet therapy (APT) for elective laparoscopic cholecystectomy (LC) is still controversial.MethodsA total of 808 patients who underwent elective LC were reviewed. We classified patients in this cohort into three groups according to thromboembolic risks: patients with no thromboembolic risk (non‐APT group, n = 653), patients with low thromboembolic risk (APT‐LR group, n = 106), patients with high thromboembolic risk (APT‐HR group, n = 49). Our perioperative management of patients with high thrombotic risks included preoperative continuation of single aspirin therapy and early postoperative reinstitution. We assessed intraoperative and postoperative bleeding/thrombotic events among three groups. Primary outcome measures were intraoperative bleeding complications (IBCs, blood loss 200 mL or more) and postoperative bleeding complications (PBCs), and the independent risk factors for increased IBC were determined by multivariate analysis. This study was approved by our institutional review board (#17011804).ResultsIn the current cohort, IBC occurred in 17 (2.1%) patients. Postoperatively, there were three PBCs (0.4%) and two thromboembolic complications (TCs, 0.2%), respectively. The occurrences of IBC and TC did not show any significant difference between the three groups, but PBC was more common in the APT‐LR group (P = 0.022). Multivariate analysis showed that only chronic cholecystitis was the independent risk factor for IBC (P < 0.001, odds ratio = 12.355), but preoperative continuation of APT or multiple APT use did not affect IBC.ConclusionWe performed elective LC safely in patients receiving APT under rigorous perioperative management of APT. Continuation of aspirin monotherapy is considered in patients with APT during elective LC.
Whole‐genome resequencing to identify candidate genes for the QTL for oleic acid percentage in Japanese Black cattle
Authors: Kawaguchi Fuki , Kigoshi Hiroto , Fukushima Moriyuki , Iwamoto Eiji , Kobayashi Eiji , Oyama Kenji , Mannen Hideyuki , Sasazaki Shinji 
Published: February 2019

AbstractIn our previous study, we detected a QTL for the oleic acid percentage (C18:1) on BTA9 in Japanese Black cattle through a genome‐wide association study (GWAS). In this study, we performed whole‐genome resequencing on eight animals with higher and lower C18:1 to identify candidate polymorphisms for the QTL. A total of 39,658 polymorphisms were detected in the candidate region, which were narrowed to 1993 polymorphisms within 23 genes based on allele differences between the high and low C18:1 groups. We subsequently selected three candidate genes, that is, CYB5R4, MED23, and VNN1, among the 23 genes based on their function in fatty acid metabolism. In each candidate gene, three SNPs, that is, CYB5R4 c.*349G > T, MED23 c.3700G > A, and VNN1 c.197C > T, were selected as candidate SNPs to verify their effect on C18:1 in a Japanese Black cattle population (n = 889). The statistical analysis showed that these SNPs were significantly associated with C18:1 (p < 0.05), suggesting that they were candidates for the QTL. In conclusion, we successfully narrowed the candidates for the QTL by detecting possible polymorphisms located within the candidate region. It is expected that the responsible polymorphism can be identified by demonstrating their effect on the gene's function.
Mechanisms of kinesin‐7 CENP‐E in kinetochore–microtubule capture and chromosome alignment during cell division
Authors: Yu Kai‐Wei , Zhong Ning , Xiao Yu , She Zhen‐Yu 
Published: February 2019

AbstractChromosome congression is essential for faithful chromosome segregation and genomic stability in cell division. Centromere‐associated protein E (CENP‐E), a plus‐end‐directed kinesin motor, is required for congression of pole‐proximal chromosomes in metaphase. CENP‐E accumulates at the outer plate of kinetochores and mediates the kinetochore‐microtubule capture. CENP‐E also transports the chromosomes along spindle microtubules towards the equatorial plate. CENP‐E interacts with Bub1‐related kinase, Aurora B and core kinetochore components during kinetochore–microtubule attachment. In this review, we introduce the structures and mechanochemistry of kinesin‐7 CENP‐E. We highlight the complicated interactions between CENP‐E and partner proteins during chromosome congression. We summarise the detailed roles and mechanisms of CENP‐E in mitosis and meiosis, including the kinetochore–microtubule capture, chromosome congression/alignment in metaphase and the regulation of spindle assembly checkpoint. We also shed a light on the roles of CENP‐E in tumourigenesis and CENP‐E's specific inhibitors.
From identification to functional characterization of cyriotoxin‐1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei
Authors: Gonçalves Tânia C. , Benoit Evelyne , Kurz Michael , Lucarain Laetitia , Fouconnier Sophie , Combemale Stéphanie , Jaquillard Lucie , Schombert Brigitte , Chambard Jean‐Marie , Boukaiba Rachid , Hessler Gerhard , Bohme Andrees , Bialy Laurent , Hourcade Stéphane , Béroud Rémy , De Waard Michel , Servent Denis , Partiseti Michel 
Published: February 2019

Background and PurposeThe NaV1.7 channel is highly expressed in dorsal root ganglia of the sensory nervous system and plays a central role in the pain signalling process. We investigated a library prepared from original venoms of 117 different animals to identify new selective inhibitors of this target.Experimental ApproachWe used high throughput screening of a large venom collection using automated patch‐clamp experiments on human voltage‐gated sodium channel subtypes and then in vitro and in vivo electrophysiological experiments to characterize the active peptides that have been purified, sequenced, and chemically synthesized. Analgesic effects were evaluated in vivo in mice models.Key ResultsWe identified cyriotoxin‐1a (CyrTx‐1a), a novel peptide isolated from Cyriopagopus schioedtei spider venom, as a candidate for further characterization. This 33 amino acids toxin belongs to the inhibitor cystine knot structural family and inhibits hNaV1.1–1.3 and 1.6–1.7 channels in the low nanomolar range, compared to the micromolar range for hNaV1.4–1.5 and 1.8 channels. CyrTx‐1a was 920 times more efficient at inhibiting tetrodotoxin (TTX)‐sensitive than TTX‐resistant sodium currents recorded from adult mouse dorsal root ganglia neurons and in vivo electrophysiological experiments showed that CyrTx‐1a was approximately 170 times less efficient than huwentoxin‐IV at altering mouse skeletal neuromuscular excitability properties. CyrTx‐1a exhibited an analgesic effect in mice by increasing reaction time in the hot‐plate assay.Conclusions and ImplicationsThe pharmacological profile of CyrTx‐1a paves the way for further molecular engineering aimed to optimize the potential antinociceptive properties of this peptide.
“Power together”: Professionals and parents of children with disabilities creating productive partnerships
Authors: Cohen Ayala , Mosek Atalia 
Published: February 2019

AbstractDisparity of power and authority in the relationship between parents and professionals has been shown to be a major challenge in creating a successful partnership in caring for children with disability. The goal of this article was to evaluate workshops attended by professionals and parents of children with disability by raising awareness to barriers related to incompatible expectations and role definitions. The research explored the experiences of the participants in order to identify factors that facilitated or impeded their collaborations. Data were collected from three workshops attended by 22 mothers of children with disability and 24 professionals (most of them are social workers). This qualitative research used interpretative phenomenological analysis to investigate the participants' experiences. Findings showed that parents and professionals joined forces to create a productive working relationship by taking advantage of power over and power together relationships. This mutual process required participants to be aware, empathic, and respectful of one another's needs and limitations; acknowledge the contribution of experiential and professional knowledge; and co‐operate in overcoming the effects of ineffective bureaucratic service systems. Interventions geared to contain emotional burden, acknowledge differential knowledge and experience, and structure the use of power are suggested.
Conical zirconia telescoping into electroformed gold: A retrospective study of prostheses supported by teeth and/or implants
Authors: Brandt Silvia , Winter Anna , Weigl Paul , Brandt Jan , Romanos Georgios , Lauer Hans‐Christoph 
Published: February 2019

AbstractBackgroundTelescopic prostheses are an evidence‐based treatment modality, and conical zirconia crowns and electro‐formed gold copings have been used for dentures supported by teeth and/or implants.PurposeWe aimed to evaluate the survival rates of zirconia‐based tooth/implant restorations.Materials and MethodsA total of 126 telescopic overdentures, all retained by conical zirconia crowns and electro‐formed gold copings, were retrospectively evaluated and failures analyzed for abutment configurations. Survival rates and modifying factors were evaluated by Kaplan‐Meier analysis, log‐rank testing, and Cox regression analysis.ResultsWe evaluated observation periods of up to 11.5 years (mean: 45.25 ± 25.11 months). Five‐year prosthesis survival was 96.9 ± 2.2% (95% CI: 92.6‐100). Six dentures had been lost, and these failures were significantly associated with specific abutment configurations.ConclusionsWithin the limitations of this retrospective study, the concept of conical zirconia telescoping into electro‐formed gold provides a viable alternative to other telescopic designs used for removable dental prostheses. The concept is well suited especially for tooth/implant‐supported prosthetic rehabilitation.
The Dexcom glucose monitoring system—An isobornyl acrylate‐free alternative for diabetic patients
Authors: Oppel Eva , Kamann Stefanie , Reichl Franz‐Xaver , Högg Christof 
Published: February 2019

BackgroundGlucose monitoring systems, for example, Freestyle Libre (Abott) and Dexcom (Nintamed), are increasingly being used instead of conventional blood sugar measurement. However, many patients have experienced adverse skin reactions such as severe allergic contact dermatitis (ACD). Finally, in August 2017, the culprit allergen in Freestyle Libre, isobornyl acrylate (IBOA), was identified.ObjectivesAfter patients have developed ACD, it is recommended that they no longer use their glucose monitoring systems. Thus, it is important to find an alternative IBOA‐free device.Patients and MethodsFive patients presented with ACD caused by Freestyle Libre. Each was patch tested with allergens from the baseline series and from a plastics and glues series, and additionally with IBOA 0.1% pet. Gas chromatography‐mass spectrometry (GC/MS) of the Freestyle Libre sensor and the Dexcom sensor was performed. The Dexcom sensor remained on the skin of all patients for at least 2 days.ResultsAll patients were sensitized to IBOA. GC/MS showed the presence of IBOA in the Freestyle Libre sensor, whereas the Dexcom sensor was IBOA‐free. None of the patients had skin reactions to the Dexcom sensor.ConclusionsPatients with Freestyle Libre and IBOA allergy may use the Dexcom sensor as an alternative for glucose monitoring.