bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bridging the Gap: Enhancing Career Readiness for Agricultural Graduates in India
Authors: Sebastian Shibi , A Anuratha , R Neelavathi , E Jamuna , S Thiruvarassan , K Senthamizh , V Vijayageetha , S Ganapathy 
Published: November 2024

Agricultural Educational institutions are striving to enhance their methodologies to equip graduates with skills that meet diverse industry demands. While graduates are trained in foundational agricultural science, there is a growing recognition that securing suitable employment requires competencies beyond technical expertise. The study identifies notable gaps in these skill sets among graduates, indicating that while educational programs assess technical abilities rigorously, there is room for improvement in developing broader employability skills. The research involved final-year undergraduate students, alumni, and employers from Tamil Nadu Agricultural University (TNAU). A 67-item questionnaire was administered to students, alumni and employers. The 67 items were grouped into 16 skill categories and percentage analysis was carried out for better understanding. The analysis revealed that a significant portion of students (67.12%) are female, reflecting a positive trend in gender participation in agricultural education. However, the preference for government jobs among 85% of students raises concerns about their willingness to explore opportunities in the private sector, which may limit their career options. The study’s findings also reveal discrepancies in perceptions of essential employability skills among students, alumni, and employers. Students and alumni rated "Listening" as the most critical skill, while employers prioritized "Problem Solving and Analytic" skills. Furthermore, the study advocates for robust career guidance programs that encourage students to consider diverse career paths, including the private sector. Additionally, addressing gender disparities in the workforce is crucial to ensure equitable opportunities for all graduates.
Seizures, periodic and rhythmic patterns in primary intraventricular hemorrhage
Authors: Stretz Christoph , Sheikh Zubeda , Maciel Carolina B. , Hirsch Lawrence J. , Gilmore Emily J. 
Published: August 2018

AbstractObjectivePrimary intraventricular hemorrhage (pIVH) uncommonly presents with seizures. There are no prior data regarding the frequency of seizures, periodic and rhythmic patterns on continuous electroencephalography (EEG), (cEEG) in these patients.MethodsWe retrospectively assessed frequency of seizures, periodic discharges, and rhythmic patterns in pIVH patients undergoing cEEG monitoring. We reviewed indications for cEEG, demographics, GCS at presentation and during cEEG, modified Graeb score (mGS), presence of hydrocephalus, cEEG duration, findings and use of antiseizure medications (ASM). cEEG patterns were classified according to location and morphology. All patterns were considered “hyperexcitable” except GRDA. The ictal‐interictal continuum (IIC) was defined as LRDA, PDs, and/or SW >1 Hz but <2.5 Hz, not meeting criteria for definite electrographic seizures.ResultsEleven patients had pIVH with median age of 81 (46–87) years and median mGS of 15 (9–23). Hydrocephalus was present in 7 (63.6%) and all underwent external ventricular drain (EVD) placement. Median cEEG recording was 19 (12–156) hours. Periodic or rhythmic EEG patterns were seen in 7 of 11 (64%), 5 of which were “hyperexcitable”. For the 5 patients with pIVH, EVDs, and hyperexcitable patterns, 4 (80%) were lateralized contralateral to the EVD and 1 (20%) was generalized to the EVD. The only significant difference between the hyperexcitable and non‐hyperexcitable group was duration of cEEG monitoring (P = 0.007).InterpretationHyperexcitable patterns were common in our cases. Further research is warranted to assess prevalence of hyperexcitable patterns, their risk factors, underlying pathophysiology, and association with neuronal injury in pIVH.
Direct Synthesis of 2‐Acyl Acridines Using Aldimines and Anthranils: Evaluation of Cytotoxicity and Anti‐Inflammatory Activity
Authors: Kim Saegun , Kundu Amit , Chun Rina , Han Sang Hoon , Pandey Ashok Kumar , Yoo Sungin , Park Junghyun , Kim Hyung Sik , Ku Jin‐Mo , Kim In Su 
Published: August 2018

AbstractRhodium (III)‐catalyzed C−H aminations of aldimines with anthranils followed by intramolecular cyclization are described. These transformations facilitate the efficient generation of 2‐acyl acridines, which are important motifs found in bioactive natural products and pharmaceuticals. All synthesized 2‐acyl acridines were first screened for cytotoxic activity against human renal carcinoma cells (CAKI‐1 and 786‐O) and human breast carcinoma cells (MCF‐7). Compound 3 z showed the most potent cytotoxic activity, which is stronger than that of doxorubicin against CAKI‐1 and 786‐O cells. In addition, compounds that exhibited potent cytotoxicities were selected for further in vitro anti‐inflammatory activity testing using interleukin‐6 (IL‐6) with lipopolysaccharide (LPS)‐induced RAW264.7 cells. Notably, compounds (3 k, 3 n, 3 s and 3 x–3 z) were found to exhibit inhibitory activities that are about two‐ to three‐times more potent than that of the anti‐inflammatory drug dexamethasone.
Hippocampal amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid GluA1 (AMPAGluA1) receptor subunit involves in learning and memory improvement following treatment withCentella asiaticaextract in adolescent rats
Authors: Binti Mohd Yusuf Yeo Nor Aqilah , Muthuraju Sangu , Wong Jia Hui , Mohammed Faruque Reza , Senik Mohd Harizal , Zhang Jingli , Yusof Siti Rafidah , Jaafar Hasnan , Adenan Mohd llham , Mohamad Habsah , Tengku Muhammad Tengku Sifzizul , Abdullah Jafri Malin 
Published: August 2018

AbstractIntroductionCentella asiaticais an herbal plant that contains phytochemicals that are widely believed to have positive effects on cognitive function. The adolescent stage is a critical development period for the maturation of brain processes that encompass changes in physical and psychological systems. However, the effect ofC. asiaticahas not been extensively studied in adolescents. The aim of this study was therefore to investigate the effects of aC. asiaticaextract on the enhancement of learning and memory in adolescent rats.MethodsThe locomotor activity, learning, and memory were assessed by using open field test and water T‐maze test. This study also examined changes in neuronal cell morphology using cresyl violet and apoptosis staining. We also performed immunohistochemical study to analyse the expression of the glutamateAMPAreceptor (α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid) GluA1 subunit and theGABAreceptor (γ‐Aminobutyric Acid) subtypeGABAAα1 subunit in the hippocampus of the same animals.ResultsWe found no significant changes in locomotor activity (p > 0.05). The water T‐maze data showed that 30 mg/kg dose significantly (p < 0.05) improved learning, memory, and the memory consolidation phase but had no effect on reversal learning (p > 0.05). Histological data revealed no neuronal morphological changes. Immunohistochemical analysis revealed increased expression of theAMPAGluA1 receptor subunit but there was no effect onGABAAreceptor α1 subunit expression in theCA1 andCA2 subregions of the hippocampus.ConclusionsTheC. asiaticaextract therefore improved hippocampus‐dependent spatial learning and memory in a dose‐dependent manner in rats through the GluA1‐containingAMPAreceptor in theCA1 andCA2 sub regions of the hippocampus.
Vulvar intraepithelial neoplasia treated with a combination of surgical excision and laser ablation during pregnancy
Authors: Wang Liangcheng , Kawabe Ayaka , Kikugawa Atsuko , Takagi Akiyoshi , Kuromaki Kenichi 
Published: August 2018

Key Clinical MessageMost vulvar intraepithelial neoplasias are associated with human papillomavirus. However, detailed surgical plans during pregnancy are rarely discussed. We suggest that the treatment policy should focus on performing surgical excision on multifocal lesions, combined surgical excision/laser ablation on single lesions, and preserving unaffected perineal skin, if possible.
The Parsortix™ Cell Separation System—A versatile liquid biopsy platform
Authors: Miller M. Craig , Robinson Peggy S. , Wagner Christopher , O'Shannessy Daniel J. 
Published: August 2018

AbstractCancer cells from solid tumors can enter the circulatory system and survive to subsequently form distant metastases. The CellSearch® system (Menarini‐Silicon Biosystems, Huntingdon Valley, PA) was the first, FDA‐cleared system that provided a reliable tool for the investigation of circulating tumor cells (CTCs), which have been shown to be strongly associated with poor survival and therapy failure. Since that time, a number of new technologies have been introduced to improve CTC detection and/or isolation for further characterization. The continued and growing interest in the “liquid biopsy” field has spurred the development of numerous different CTC technologies. However, selecting the most appropriate CTC platform for individual applications can be challenging. No consensus has yet been reached in the community regarding which liquid biopsy technology is optimal. Here, we introduce the Parsortix™ Cell Separation System (ANGLE North America, Inc., King of Prussia, PA), a microfluidic based technology that captures rare cells based on size and deformability, offers reproducibly high capture efficiency, and produces highly enriched, viable (viability dependent on preservative used) CTCs that are amenable to a multitude of downstream analyses, including the isolation and interrogation of single cells. © 2018 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.
Assessment of the results of a three‐year program for National Standardization and Quality Improvement of Medical Laboratories on Drug of Abuse Testing by the Ministry of Health in Turkey
Authors: Küme Tuncay , Mercan Ferzane , Topsakal Hatice , Karakukcu Cigdem , Şeneş Mehmet , Pınar Aslı , Gürler Mukaddes , Kalafat Hakan , Ünal Belgin , Verstraete Alain G. , Hamurtekin Yeşim , Aydınlı Ahmet , Şenol Yasemin , Eğin Muhammed Ertuğrul , Cihan Alper , Kazancı Elif Güler , Gümüş Eyüp 
Published: August 2018

AbstractThe aim of this study is to assess the results of inspections in the last three years of drug abuse testing in medical laboratories according to the latest regulations in Turkey. The on‐site inspections of medical laboratories for drugs abuse testing performed in Alcohol and Drug Addiction Treatment Centers during 2014–2016 are described, and laboratory processes and performance evaluated. The performance of 35 laboratories in 2014, 62 laboratories in 2015, and 94 laboratories in 2016 were scored as the sum of the scores for all answers on the inspection form. An inspected laboratory was considered to have an unconformity if the total score was less than 2/3 of maximum score. The total scores of inspections and the number of laboratories with between years were compared using one‐way analysis of variance and slope Chi‐square for trend test, respectively. Total scores increased statistically significantly from 35.9 ± 16.2 in 2014, to 43.5 ± 16.3 in 2015 and 49.1 ± 1.3 in 2016 (p < 0.001). The laboratories with unconformities decreased statistically significantly from 57% in 2014 to 37% in 2015 and 22% in 2016 (p < 0.001). The published legislation and the inspections contributed to national standardization and improved quality of service in medical laboratories for drug abuse testing.
Evaluation of the Stoichiometry between PtCl62− and TOA+ Ions during the Liquid/Liquid Extraction
Authors: Wu Shu , Nguyen Linh , Dang Jenny , Liang Kevin , Dail Christopher , Henriquez Brenda , Huynh Quyen T. , Dinh Uyen N. , Liang Yuhao , Anz Samir , Sun Peng 
Published: August 2018

AbstractThe transfer of PtCl62− ions into the organic phase facilitated by TOA+ is the very first step in the Brust‐Schiffrin (BS) two‐phase synthesis of monolayer protected Pt nanoparticles. However, the stoichiometry between TOA+ and PtCl62− during the facilitated transfer process is still unknown. In this paper, a hemispherical micro‐liquid/liquid interface, which is formed between a PtCl62− aqueous filled micropipette and an organic phase, has been employed to study the stoichiometry of TOA+ facilitated transfer of PtCl62−. Due to the even diffusion field at the hemispherical micro‐liquid/liquid interface, the theoretical i‐V curve for TOA+ facilitated transfer of PtCl62− can be derived in a simple way. By simulating the theoretical i‐V curve to the experimental voltammogram, the stoichiometry of TOA+ facilitated transfer of PtCl62− was evaluated to be 8.
Effect of dietary supplement from mono‐culture fermentation of Moringa oleifera seeds by Rhizopus stolonifer on hematology and markers linked to hypercholesterolemia in rat model
Authors: Adedayo Majekodunmi R. , Akintunde Jacob K. , Sani Alhassan , Boligon Aline A. 
Published: August 2018

AbstractMono‐culture fermentation by Rhizopus stolonifer could promote the healthiness of immune systems and cholesterol levels. Hence, we examined the effect of diet from mono‐culture fermentation of Moringa oleifera seeds by R. stolonifer (MCF‐MORS) on hematological parameters and fundamental indicators of hypercholesterolemia in rat. The animals were divided into six groups (n = 6). Group 1 was placed on basal diet. Group II, III, IV and V were placed on a basal diets supplemented with 7.5%, 15%, 22.5% and 30%, respectively, of MCF‐MORS. Group VI was placed on basal diet fed with unfermented M. oleifera seeds (UF‐MOS). The experiment lasted for eight weeks. The results revealed 7.5% MCF‐MORS as better biological method to augment PCV, RBC and Hb count in animal model. Also, 7.5% and/or 15% MCF‐MORS demonstrated highest levels in centrophils, neutrophils and eosinophils, whereas the levels of lymphocytes, basophils and monocytes showed no significant difference. Similarly, 7.5% and 15% MCF‐MORS modulated LDL and HDL, respectively, better than UF‐MOS; but showing no difference in cholesterol level. MCF‐MORS also maintained architectural integrity of villi and splenocytes better than UF‐MOS. We therefore concluded that diet from MCF‐MORS at 7.5% and 15% modulates HDL, LDL, cholesterol and immune system‐related disorders better than UF‐MOS in rat model.
JAGN1 is required for fungal killing in neutrophil extracellular traps: Implications for severe congenital neutropenia
Authors: Khandagale Avinash , Lazzaretto Beatrice , Carlsson Göran , Sundin Mikael , Shafeeq Sulman , Römling Ute , Fadeel Bengt 
Published: August 2018

Abstract
Mutations in the gene JAGN1 were recently discovered in patients with severe congenital neutropenia (SCN). Neutrophils release neutrophil extracellular traps (NETs) consisting of decondensed chromatin decorated with various granular proteins such as neutrophil elastase and myeloperoxidase (MPO) to combat microbial infections. However, whether JAGN1 is required for the formation or function of NETs is not known. Here, we analyzed primary neutrophils from a patient with homozygous JAGN1 mutations with respect to phorbol myristate acetate (PMA)-induced NET formation. NET release was observed, but there appeared to be a reduced level of expression of MPO in the NETs. To study this further, we differentiated HL-60 cells into neutrophil-like cells and silenced JAGN1 expression by transfection with siRNA. These cells remained capable of producing NETs, but MPO expression was severely affected, and NETs released by JAGN1-silenced cells were ineffective in killing Candida albicans. The candidacidal function was restored upon treatment with GM-CSF or addition of MPO. GM-CSF also up-regulated the expression of calprotectin in NETs. Notably, JAGN1 did not impact on N-glycosylation of MPO in neutrophil-like HL-60 cells. These studies shed light on the susceptibility of SCN patients to fungal infections and the role of JAGN1 for the antimicrobial function of neutrophils exerted by NETs.
The present study explores the role of JAGN1 for the candidacidal function of neutrophil extracellular traps, with implications for severe congenital neutropenia.
Dosimetric comparison of surface mould HDR brachytherapy with VMAT
Authors: Boman Eeva L. , Paterson Dean B. , Pearson Shelley , Naidoo Nichola , Johnson Carol 
Published: August 2018

AbstractIntroductionThe aim of this study was to investigate the dosimetric differences between surface mould high‐dose‐rate (HDR) brachytherapy and external beam volumetric‐modulated arc therapy (VMAT) for two treatment sites.MethodsPreviously treated HDR brachytherapy surface mould scalp (n = 4) and lower leg (n = 3) treatments were retrospectively analysed. The VMAT plans were optimised using an additional 3‐mm setup margin on the clinical target volume (CTV) of the previously treated HDR plans. The HDR plans were calculated and normalised using the TG‐43 formalism and recalculated with Acuros BV (AC).ResultsOn average, the mean brain and normal tissue doses were reduced by 44.8% and 27.4% for scalp and lower leg VMAT cases, respectively, when compared to AC calculated HDR plans. For VMAT plans, the average dose to a 1‐mm thick skin structure deep to the target volume was not any lower than that in AC HDR plans. On average, the CTV coverage was 13.8% and 9.6% lower for scalp cases with AC dose calculation than with TG‐43 and 8.3% and 5.3% lower for lower leg cases if 0‐ or 1‐cm backscatter material was applied above the catheters, respectively.ConclusionsVMAT is a feasible treatment option in the case of extensive skin malignancies of the scalp and lower leg. Uncertainties related to delivered dose with HDR brachytherapy when using the TG‐43 dose calculation model or possible air gaps between the mould and skin favour the use of VMAT. The potential soft tissue deformation needs to be considered if VMAT is used.
Properties of Polydimethylsiloxane and Magnetoactive Polymers with Electroconductive Particles
Authors: Prem Nina , Vega Jhohan Chavez , Böhm Valter , Sindersberger Dirk , Monkman Gareth J. , Zimmermann Klaus 
Published: August 2018

AbstractMagnetoactive polymers are intelligent materials whose mechanical and electrical characteristics are reversibly influenced by external magnetic stimuli. They consist of a highly elastic polymer matrix in which magnetically soft and/or hard particles are distributed by means of special fabrication processes. In addition to ferromagnetic particles such as carbonyl iron powder, electrically conductive particles may also be embedded into the polymer matrix. After characterizing a range of compounds, this work focuses on a comparison of the electrical properties and the suitability of various materials for applications, with particular emphasis on integration into 3D and 6D printing processes. 6D printing is based on the selective positioning of particles in a 3D polymer matrix with a further three degrees of freedom for a graduated dispersion of the particles at certain points and in desired directions. The aim is therefore to ensure that the polymers containing electroconductive tracks have the best possible electrical properties, that is, low resistivity but are still capable of being printed. A comparison between the traditionally used compounds containing graphite and carbon black is made for the first time. This latter is found to be greatly superior both in terms of electrical conductivity and applicability to 3D printing and 6D printing.
An Efficient Pd & Pt‐Catalyzed H/D Exchange Approach towards the Synthesis of Deuterium‐Labeled Antiviral Prodrugs, Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide
Authors: Shen Hangzhou , Liu Yingshuai , Tian Xiaomeng , Zhang Xiquan , Zhang Yinsheng 
Published: August 2018

AbstractTo support clinical bioequivalence (BE) studies of tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide fumarate (TAF), both deuterium‐labeled TDF and TAF (or their free bases, TD & TA) are highly desired for use as an internal standard. We have developed a method to prepare racemic [D8]9‐(2‐hydroxypropyl)adenine (racemic R/S‐HPA) using a 10%Pd/C & PtO2 catalyzed H−D exchange reaction as the key step to introduce the label in a highly efficient and cost‐effective way. The labeled R/S‐HPA was converted to racemic [D8]9‐[2‐phosphonomethoxypropyl]adenine ([D8] R/S‐PMPA) in two steps. Using [D8] R/S‐PMPA as a common intermediate, thus, we further synthesized [D8] R/S‐tenofovir disoproxil fumarate and [D8]tenofovir alafenamide in 2–3 steps with 60% and 20% overall yield, respectively.
Special arithmetic of flavor
Authors: Caorsi Matteo , Cecotti Sergio 
Published: August 2018

AbstractWe revisit the classification of rank-1 4d$$ \mathcal{N}=2 $$N=2QFTs in the spirit of Diophantine Geometry, viewing their special geometries as elliptic curves over the chiral ring (a Dedekind domain). The Kodaira-Néron model maps the space of non-trivial rank-1 special geometries to the well-known moduli of pairs (ε, F∞) where E is a relatively minimal, rational elliptic surface with section, andF∞a fiber with additive reduction. Requiring enough Seiberg-Witten differentials yields a condition on (ε, F∞) equivalent to the “safely irrelevant conjecture”. The Mordell-Weil group of E (with the Néron-Tate pairing) contains a canonical root system arising from (−1)-curves in special position in the Néron-Severi group. This canonical system is identified with the roots of the flavor group F: the allowed flavor groups are then read from the Oguiso-Shioda table of Mordell-Weil groups. Discrete gaugings correspond to base changes. Our results are consistent with previous work by Argyres et al.
The Predictive Value of Pulse Wave Velocity for Anastomotic Leakage After Colorectal Surgery
Authors: Venara A. , Jaouen R. , Lermite E. , Le Naoures P. , Casa C. , Mirallié E. , Duchalais E. , Hamy A. 
Published: August 2018

AbstractBackgroundArterial perfusion defects are a risk factor for anastomotic leakage (AL) following colorectal surgery. Measuring arterial stiffness using pulse wave velocity (PWV) is known to reflect the performance of the arterial network. The objective of this study was to assess the predictive value of PWV for AL after colorectal surgery.MethodsA prospective monocentric study was conducted on all consecutive patients who underwent colorectal surgery scheduled between March 1, 2016 and May 1, 2017. Patients were divided into two groups according to the PWV which was measured preoperatively using the pOpmètre® device: PWV+ (PWV > 10 m/s) and PWV− (PWV ≤ 10 m/s). We then compared the PWV+ and PWV− groups. The primary endpoint was the AL rate.ResultsA total of 96 patients were studied, including 60 in the PWV− group and 36 in the PWV+ group. Patients in the PWV+ group were more at risk of presenting with AL than those in the PWV− group (6.25 vs 0%) (p = 0.002). There was no difference in immediate postoperative complications between the two groups apart from the length of hospital stay. PWV predicted the appearance of AL with a sensitivity of and a negative predictive value of 100%.ConclusionMeasuring PWV could be a used as a predictive examination in the early detection of AL after colorectal surgery.