bluuebunny/crossref_metadata_2025_split huggingface dataset:
CRISPR-Cas9 human gene replacement and phenomic characterization inCaenorhabditis elegansto understand the functional conservation of human genes and decipher variants of uncertain significance
Authors: McDiarmid Troy A. , Au Vinci , Loewen Aaron D. , Liang Joseph , Mizumoto Kota , Moerman Donald G. , Rankin Catharine H. 
Published: July 2018

AbstractOur ability to sequence genomes has vastly surpassed our ability to interpret the genetic variation we discover. This presents a major challenge in the clinical setting, where the recent application of whole exome and whole genome sequencing has uncovered thousands of genetic variants of uncertain significance. Here, we present a strategy for targeted human gene replacement and phenomic characterization based on CRISPR-Cas9 genome engineering in the genetic model organismCaenorhabditis elegansthat will facilitate assessment of the functional conservation of human genes and structure-function analysis of disease-associated variants with unprecedented precision. We validate our strategy by demonstrating that direct single-copy replacement of theC. elegansortholog (daf-18) with the critical human disease-associated gene Phosphatase and Tensin Homolog (PTEN) is sufficient to rescue multiple phenotypic abnormalities caused by complete deletion ofdaf-18, including complex chemosensory and mechanosenory impairments. In addition, we used our strategy to generate animals harboring a single copy of the known pathogenic lipid phosphatase inactive PTEN variant (PTEN-G129E) and showed that our automatedin vivophenotypic assays could accurately and efficiently classify this missense variant as loss-of-function. The integrated nature of the human transgenes allows for analysis of both homozygous and heterozygous variants and greatly facilitates high-throughput precision medicine drug screens. By combining genome engineering with rapid and automated phenotypic characterization, our strategy streamlines identification of novel conserved gene functions in complex sensory and learning phenotypes that can be used asin vivofunctional assays to decipher variants of uncertain significance.
Openness to participating in a victim-offender conference
Authors: Paul Gregory Dennis , Schenck-Hamlin William J. 
Published: July 2018

PurposeThis paper aims to use the theory of planned behavior to evaluate factors that influence openness to participating in a victim-offender conference (VOC).Design/methodology/approachConsistent with theory of planned behavior recommendations, the study uses a vignette-based design to assess participation openness as willingness to participate in a VOC if they were victims of a property crime. It evaluates the goodness of fit of a hypothesized structural model of participation openness to the data and the utility of a theory of planned behavior model as opposed to simply an outcome-driven model.FindingsFindings from a hierarchical linear regression illustrate that a theory of planned behavior model explains a greater percentage of participation willingness than does an outcome-driven model. Analysis using structural equation modeling suggests that participation openness is largely a function of subjective norms, anticipated affect and anticipated outcomes.Research limitations/implicationsLimitations spring largely from sampling method and research design. Research implications pertain to the utility of theory of planned behavior in expanding research of VOC participation openness to include not only outcomes but also relational and contextual factors.Practical implicationsThe manuscript identifies several implications for training facilitators, talking with prospective VOC participants and advocating for restorative justice programs.Originality/valueUse of the theory of planned behavior as a lens for understanding openness to VOC participation gives researchers and practitioners a wider and more nuanced understanding of why people would generally be willing to participate in a VOC if they were the victim of an offense.
Supply chain resilience: a dynamic and multidimensional approach
Authors: Adobor Henry , McMullen Ronald S. 
Published: July 2018

PurposeThe purpose of this paper is to present a conceptual framework on resilience types in supply chain networks.Design/methodology/approachUsing a complex adaptive systems perspective as an organizing framework, the paper explores three forms of resilience: engineering, ecological and evolutionary and their antecedents and links these to four phases of supply chain resilience (SCRES): readiness, response, recovery, growth and renewal.FindingsResilient supply chains need all three forms of resilience. Efficiency and system optimization approaches may promote quick recovery after a disruption. However, system-level response requires adaptive capabilities and transformational behaviors may be needed to move supply chains to new fitness levels after a disruption. The three resilience types discussed are not mutually exclusive, but rather complement each other and there are synergies and tradeoffs among these resilience types.Research limitations/implicationsThe empirical validation of the theoretical propositions will open up new vistas for supply chain research. Possibilities exist for analyzing and assessing SCRES in multiple and more comprehensive ways.Practical implicationsThe findings of the research can help managers refine their approaches to managing supply chain networks. A more balanced approach to supply chain management can reduce the risks and vulnerabilities associated with supply chain disruptions.Originality/valueThis study is unique as it conceptualizes SCRES in multiple ways, thereby extending our understanding of supply chain stability.
Translating participatory budgeting in Russia: the roles of inscriptions and inscriptors
Authors: Aleksandrov Evgenii , Timoshenko Konstantin 
Published: July 2018

Purpose
The purpose of this paper is to explore how participatory budgeting (PB) as a democratic governance tool has been translated within the Russian public sector by addressing the local specifics of its design and mobilization through the formation of networks.

Design/methodology/approach
The paper is based on a case study of one pioneering municipality. Data have been gathered through triangulation of interviews, document search, video and netnographic observations. By relying on ideas from actor–network theory, the study focuses on the relational and rhetorical work of human (allies/inscriptors) and non-human (inscriptions) actors involved in the development of PB in Russia.

Findings
The findings indicate that the initial democratic values of PB underwent several stages of translation as a continuous inscription-building process and the formation of networks. The main finding is that putting democratic idea(l)s of PB into practice proved problematic, since PB depended on many “allies” which were not always democratic. Paradoxically, in order to launch democratic practices in Russia, PB relied largely on bureaucratic and even New Public Management inscriptions, which it was originally supposed to fight against. Notwithstanding, while these inscriptions can fog the democratic values of PB, they are also capable of uncovering its democratic potential over time, albeit not for a long time as the “external referee” is needed.

Originality/value
The paper juxtaposes PB development in Russia with the translation literature. Not only does the study emphasize the role of human, but non-human actors as well.
Boundary objects for institutional work across service ecosystems
Authors: Sajtos Laszlo , Kleinaltenkamp Michael , Harrison Julie 
Published: July 2018

Purpose
Institutional arrangements for collaborative purposes have gained increasing attention within research on service ecosystems. For collaborations to be effective, actors need to undertake institutional work that will result in new institutional arrangements. When institutional work takes place across service ecosystems, actors may be confronted with non-harmonious or conflicting institutional arrangements, which need to be reconciled by translating the incompatible views of diverse ecosystems. Therefore, the purpose of this paper is to introduce the concept of boundary objects as a means of facilitating institutional work across ecosystems, and present their mechanism in undertaking institutional work.

Design/methodology/approach
Longitudinal qualitative interviews were conducted with three key actors (funding agency, service provider and clinicians) in providing home-based support services (HBSS). The data were analyzed by undertaking a thematic analysis of the transcripts, which helped to identify the actors’ views on the nature of HBSS and its impact as a boundary object within the implementation of the case-mix system, and thus to empirically illustrate the theoretical assumptions.

Findings
The data assisted in the creation of a conceptualization that maps out the process of boundary objects facilitating (disrupting and creating) institutional work. This study supports that boundary objects disrupt boundaries between actors’ ecosystems, which was a sufficient condition to dismantle institutional support for the practices of individual fields. Furthermore, the object has changed the type and extent of interaction between actors in an ecosystem to allow these actors to redefine their identity and role in the new institutional arrangement.

Originality/value
This work has developed a novel conceptualization for a boundary object-led translation process in facilitating institutional work. To the researchers’ knowledge, this is the first study to explore the processes and mechanisms of boundary objects in facilitating institutional work across ecosystems.
Game-changers: dynamic capabilities’ influence on service ecosystems
Authors: Nenonen Suvi , Gummerus Johanna , Sklyar Alexey 
Published: July 2018

Purpose
Service-dominant logic acknowledges that actors can influence how service ecosystems evolve through institutional work, but empirical research is only nascent. This paper advances understanding of ecosystem change by proposing that dynamic capabilities are a special type of operant resources enabling actors to conduct institutional work. Consequently, the purpose of this paper is to explore which dynamic capabilities are associated with proactively influencing service ecosystems.

Design/methodology/approach
Drawing on service-dominant logic, institutional work and dynamic capabilities, this exploratory study assumes an actor-centric perspective and proposes a conceptual model with a hierarchy of dynamic capabilities as the antecedents for successfully influencing service ecosystems. The research model was tested with survey data using partial least squares structural equation modeling.

Findings
Among the dynamic capabilities studied, “visioning” and “influencing explicit institutions” directly affect “success in influencing service ecosystems,” whereas “timing” does so indirectly through “influencing explicit institutions.” The other dynamic capabilities studied have no significant effect on “success in influencing service ecosystems.” “Success in influencing service ecosystems” positively affects the “increased service ecosystem size and efficiency.”

Practical implications
In addition to reactively positioning and competing at the marketplace, firms can choose to proactively influence their service ecosystems’ size and efficiency. Firms aiming to influence service ecosystems should particularly develop dynamic capabilities related to visioning, timing and influencing explicit institutions.

Originality/value
This research is the first service-dominant logic investigation of the linkage between the actors’ dynamic capabilities and their ability to influence service ecosystems.
A systemic logic for platform business models
Authors: Fehrer Julia A. , Woratschek Herbert , Brodie Roderick J. 
Published: July 2018

Purpose
The purpose of this paper is to introduce a new business model logic, highlighting value processes in and properties of platform business models to inform business model thinking from a systemic and dynamic perspective. It challenges the idea of firms managing, influencing and controlling entire activity systems.

Design/methodology/approach
The study traces the evolution of different approaches to business models and assesses theories that explain value cocreation and systemic value capture to develop a new business model logic.

Findings
Business model thinking has evolved away from Porter’s value chain to a new logic based on open networks and platforms. This study develops a framework for understanding platform business models from a systemic perspective. Derived from service-dominant logic, this new business model logic responds to phenomena in contemporary business environments characterized by increasing connectivity and sociality among actors.

Research limitations/implications
The framework, developed from an extensive body of business model literature, has yet to be subjected to empirical investigation. Future research may involve the exploration of business model design processes and business model innovation from a systemic perspective.

Practical implications
Managers who aim to design their business models based on the logic of platform businesses require an understanding of their organization’s collaboration potential, technological interfaces and potential to leverage network relationships. This research guides start-ups and incumbents to evaluate their platform potential.

Originality/value
This study systematically emancipates the business model logic from a firm-centered, inside-out perspective, focuses on network relationships beyond the customer–firm dyad, explains value processes beyond organizational borders and rethinks value capture from a systemic perspective.
How price fairness and fit affect customer tariff evaluations
Authors: Leinsle Philipp , Totzek Dirk , Schumann Jan Hendrik 
Published: July 2018

Purpose
Promotional cues related to notions of fair prices or pricing designed to fit consumers’ needs are prevalent for many service offers. The purpose of this paper is to investigate how both customers’ price fairness and idiosyncratic fit perceptions shape their tariff evaluations.

Design/methodology/approach
Two experimental studies involving different tariff types and service contexts test the complex interplay of customers’ perceived price fairness and idiosyncratic fit with customer and context characteristics on their tariff evaluations.

Findings
Customers judge tariffs drawing on both the perceived price fairness and idiosyncratic fit, driven by the perceived price level of the tariff and the perceived pricing transparency of the firm. Customers’ service usage and consumption goals moderate these effects: heavy users and hedonic consumers indicate lower price sensitivity while focusing more on their transparency perception. The role of perceived price fairness and idiosyncratic fit for tariff choice depends on the tariff/service context; idiosyncratic fit is important when it is incidental (e.g. flat rates) rather than intentional (i.e. customized tariffs) and when customers lack the expertise or confidence to evaluate price fairness such as in the case of relatively new services.

Originality/value
Prior studies focused on either price fairness or idiosyncratic fit and thus cannot fully explain the complex interplay between both in the context of tariff choice. This paper explicates the conditions that affect the relative importance of both concepts and under which incidental offers are better received than premeditated ones.
Is profit sharing good for the environment? Positive evidence from French firms
Authors: Fakhfakh Fathi , FitzRoy Felix 
Published: July 2018

PurposeThe purpose of this paper is to look at the effect of profit sharing (PS) on the ability of the firm to take care of the environment.Design/methodology/approachIn a large cross-section of French firms, the authors find strong associations between PS and various innovations with environmental benefits. With cross-sectional data from the Community Innovation Survey and FARE, the authors estimate simultaneous equations for these effects, with endogenous PS.FindingsThis relationship between PS and environmental innovation is plausible, since workers benefit more than outside owners from a better local environment. To the best of the authors’ knowledge, this paper provides the first empirical evidence, so the results suggest PS supports environmental policy, in addition to its other, better known incentive benefits.Research limitations/implicationsFurther studies, using panel data, are needed.Practical implicationsFinancial participation may be considered as an additional tool to protect the environment.Originality/valueThis is the first paper looking at the impact of PS on the ability of the firm to take care of the environment. In this critical period when policy makers are searching for ways to limit global warming and protect the environment, the authors have presented here the first evidence that financial participation helps to support these policies.
Developing a measurement instrument of knowledge management implementation in the Iranian oil industry
Authors: Ghasemi Behzad , Valmohammadi Changiz 
Published: July 2018

Purpose
The purpose of this paper is to develop a measurement instrument toward knowledge management (KM) implementation in the Iranian oil industry.

Design/methodology/approach
Based on an in-depth study of the relevant literature, the critical success factors (CSFs) related to the sub-factors were identified. Then, exploratory and confirmatory factor analysis was used to validate the instrument. Finally, based on the developed instrument, the KM implementation was evaluated in the subsidiaries of the Iranian oil industry.

Findings
The obtained results reveal the 13 factors as follows: human resource management; KM processes; information technology; business strategy; intellectual capital; KM system; executive practices of KM; management information system; culture; partnership and cooperation with business partners; KM road map; leadership commitment and support; and organizational environment.

Research limitations/implications
As this study was conducted in the Iranian oil industry, cautious should be taken regarding the generalizability of the results.

Practical implications
The proposed instrument can help policymakers and top managers of the subsidiaries of Iranian oil industry in successful implementation and measurement of their KM practices.

Originality/value
Identification and measurement of the CSFs of KM implementation through developing a comprehensive instrument in the context of the Iranian oil industry.
Unexpected consequences in the operation of urban environments
Authors: Pérez-delHoyo Raquel , Andújar-Montoya María Dolores , Mora Higinio , Gilart-Iglesias Virgilio 
Published: July 2018

Purpose
The purpose of this paper is to study the unexpected consequences in the operation of urban environments. Prediction within the urban planning process often presents difficulties and unintended consequences. It is not enough to develop a good project. Unexpected consequences are possible because of the environment. The authors argue that these problems of uncertainty can be minimized with citizen participation and the use of new technologies.

Design/methodology/approach
The problem of how urban planning initiatives result in unexpected consequences is described. These effects are determined by studying a series of cities and real urban environments. A case study on urban accessibility is developed for a better understanding of the problem.

Findings
Avoiding unexpected consequences in the operation of urban environments is strongly linked to the concept of Smart City 3.0. This concept is based on the co-creation. In this line to address the problem, a citizen-centric methodology using the latest information and communications technologies and internet of things technologies is presented. As a practical application, different categories of unexpected events related to the Faculty of Education building at the University of Alicante have been identified as a consequence of the impact of its environment. An uncomfortable or non-accessible environment causes unforeseen behaviour of individuals.

Originality/value
There are no analytical tools to investigate how aspects of the urban environment cause uncertainty about the acceptance of projects by future citizen users. This work takes a step forward in that direction.
Researches status and trends of management cybernetics and viable system model
Authors: Vahidi Amin , Aliahmadi Alireza , Teimoury Ebrahim 
Published: July 2018

PurposeThis paper reviews the underpinning principles and scientific trends of cybernetics and the viable system model (VSM). Therefore, this paper aims to guide authors and managers active in management cybernetics and to inform them about the past, current and future trends in this discipline.Design/methodology/approachThis paper adopts both qualitative and quantitative methods. First, a descriptive and qualitative approach is used to review and analyze management cybernetics historical trends. Then, a frequency analysis (quantitative) is conducted on the 1,000 first publications in the field.FindingsThe cybernetics was emerged in the Josiah Macy conference in 1946. Then, Wiener introduced the field of cybernetics and Ashby, Von Foerster and McCulloch developed this concept as a discipline. The Management cybernetics field that was introduced by Beer is a combination of system, control and management sciences. Beer presented VSM as an operational model in this area. Analyzing the 1,000 top-ranked publications shows that the introduction of this field reached maturity and further development became relatively mature. Moreover, based on the analyzed trends, VSM model application can now be strongly attractive. In this paper, the main journals, authors and research trends are analyzed. The main application area of this model is in the IT field and large-scale organizations.Practical implicationsThe present paper’s implication for practitioners and researchers is guiding authors and managers to most appropriate studies in the field, so that they can produce and use the most efficient studies in this field.Social implicationsThe fields of IT, Policy-Making, Production, Social Issues, Service industry, Software developers, etc., are some of this paper’s implications for industry and society.Originality/valueIn this paper, the steps of VSM development are investigated. Then, recent trends (classifications, authors, journals and topics analysis) are surveyed by analyzing the top 1,000 publications in this field. This paper would help researchers find more appropriate research fields. In addition, it helps practitioners find the optimum solutions based on management cybernetics for their problems among vast numbers of publications.