bluuebunny/crossref_metadata_2025_split huggingface dataset:
Training medical students and residents in the use of electronic health records: a systematic review of the literature
Authors: Rajaram Akshay , Hickey Zachary , Patel Nimesh , Newbigging Joseph , Wolfrom Brent 
Published: September 2019

Abstract

Objective
Our objectives were to identify educational interventions designed to equip medical students or residents with knowledge or skills related to various uses of electronic health records (EHRs), summarize and synthesize the results of formal evaluations of these initiatives, and compare the aims of these initiatives with the prescribed EHR-specific competencies for undergraduate and postgraduate medical education.

Materials and Methods
We conducted a systematic review of the literature following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta Analyses) guidelines. We searched for English-language, peer-reviewed studies across 6 databases using a combination of Medical Subject Headings and keywords. We summarized the quantitative and qualitative results of included studies and rated studies according to the Best Evidence in Medical Education system.

Results
Our search yielded 619 citations, of which 11 studies were included. Seven studies involved medical students, 3 studies involved residents, and 1 study involved both groups. All interventions used a practical component involving entering information into a simulated or prototypical EHR. None of the interventions involved extracting, aggregating, or visualizing clinical data for panels of patients or specific populations.

Discussion
This review reveals few high-quality initiatives focused on training learners to engage with EHRs for both individual patient care and population health improvement. In comparing these interventions with the broad set of electronic records competencies expected of matriculating physicians, critical gaps in undergraduate and postgraduate medical education remain.

Conclusions
With the increasing adoption of EHRs and rise of competency-based medical education, educators should address the gaps in the training of future physicians to better prepare them to provide high quality care for their patients and communities.
Within and between firm trends in job polarization: the roles of globalization and technology
Authors: Kerr Sari , Maczulskij Terhi , Maliranta Mika 
Published: September 2019

AbstractWe analyze occupational polarization within and across firms using a census of matched employer–employee panel data from Finland in the period of 2000–2014. As in most industrialized countries, the Finnish occupational distribution has polarized over the last decades. Using decomposition analysis, we find that jobs involving low-level service tasks increase mostly through the entry dynamics, while the high-level abstract task share increases largely within continuing firms. Worker-level occupational mobility points to some skill upgrading within continuing firms, while labor force entry and retirement contribute the polarizing trend. Instrumental variables (IVs) regressions confirm that this occupational restructuring is affected by the globalization of economic activity, including trade in goods and services, offshoring and outsourcing. For example, firms that outsource tasks abroad are more prone to lay off production workers, while domestic outsourcing leads to a reduction of both cognitive and service employees.
Tough Problems, Science Gaps, and Investment Priorities for Forest-Sector Research: Conversations at Seven Dialogues
Authors: Guldin Richard W 
Published: September 2019

Abstract
At seven small-group dialogues held across the United States, field natural-resource professionals were asked to describe the toughest problems facing them over the next 10–15 years. Thirty-five problems were identified, spanning all three components of sustainability—ecological, economic, and social. Most were socioeconomic problems related to people’s choices and values. Key science gaps contributing to the problems’ toughness and top investment priorities to fill critical gaps were described. The problems and priorities identified were then compared to ones identified since 1996 by panels of experts who compiled previous national research reports. Field professionals’ views were consistent with the previous findings and illustrated they have detailed, nuanced understandings of the challenges facing them. Top priorities from the dialogues suggest that socioeconomic forces driving ecological changes are poorly understood. Potential mitigation measures will depend on broader interdisciplinary research delving into sciences beyond ecology, such as demographics, sociology, political science, governance, and economics.
Asian Lessons in the Cold War Classroom: Trade Union Networks and the Multidirectional Pedagogies of the Cold War in Asia
Authors: Leow Rachel 
Published: September 2019

Abstract
This paper invites us to move beyond an elite, “pedagogical” view of Third World diplomatic non-alignment, by examining trade unions as sites of “subaltern internationalism” in the early Cold War. Trade unions were targets of both communist and anticommunist pedagogical programs, spearheaded principally by the World Federation of Trade Unions (WFTU) and the rival International Confederation of Free Trade Unions (ICFTU), both of which competed to teach Asians how to be good trade unionists. But despite their ideological designs, I argue that these internationalist structures of the “Cold War classroom” facilitated, instead, unexpected encounters and fraternal connections that were experienced, and are best seen, at the level of the personal. After offering an overview of these Cold War macrostructures, the paper moves to the microhistorical scale to highlight one such set of personal networks that coalesced around a single “trade union expert.” George L-P Weaver was an African-American trade unionist whose pedagogical work took him to Okinawa and Singapore in the 1950s but whose dialogical encounters with Asian trade unionists had transformative effects on his ideological convictions afterward, challenging, in particular, his views on the role of the People’s Republic of China in the Cold War and of the “communism” of Chinese overseas communities in Singapore. In all, this paper suggests that trade unions offer us a rich site in which to recover individual dynamics that challenge and complicate, from below, the binary logics of the Cold War in Asia.
Definable inapproximability: new challenges for duplicator
Authors: Atserias Albert , Dawar Anuj 
Published: September 2019

AbstractWe consider the hardness of approximation of optimization problems from the point of view of definability. For many $\textrm{NP}$-hard optimization problems it is known that, unless $\textrm{P} = \textrm{NP} $, no polynomial-time algorithm can give an approximate solution guaranteed to be within a fixed constant factor of the optimum. We show, in several such instances and without any complexity theoretic assumption, that no algorithm that is expressible in fixed-point logic with counting (FPC) can compute an approximate solution. Since important algorithmic techniques for approximation algorithms (such as linear or semidefinite programming) are expressible in FPC, this yields lower bounds on what can be achieved by such methods. The results are established by showing lower bounds on the number of variables required in first-order logic with counting to separate instances with a high optimum from those with a low optimum for fixed-size instances.
Using Elasticities to Derive Optimal Bankruptcy Exemptions
Authors: Dávila Eduardo 
Published: September 2019

AbstractThis article studies the optimal determination of bankruptcy exemptions for risk averse borrowers who use unsecured contracts but have the possibility of defaulting. In a large class of economies, knowledge of four variables is sufficient to determine whether a bankruptcy exemption level is optimal or should be increased or decreased. These variables are 1. the composition of households’ liabilities, 2. the sensitivity of the credit supply schedule to exemption changes, 3. the probability of filing for bankruptcy with non-exempt assets, and 4. the value given by households to a marginal dollar in different states, which can be mapped to changes in households’ consumption. I recover empirical estimates of the sufficient statistics using U.S. data over the period 2008–16 and find that increasing exemption levels improves overall welfare, although there is substantial variation in estimated welfare gains across U.S. states and income quintiles.
Frictional Goods Markets: Theory and Applications
Authors: Bethune Zachary , Choi Michael , Wright Randall 
Published: September 2019

Abstract
We analyse dynamic general equilibrium models with more-or-less directed search by informed buyers and random search by uninformed buyers. This nests existing specifications and generates new insights. A quantitative application concerns the welfare cost of inflation, which is known to be quite high with pure random search and low with pure directed search. Our calibration implies the impact of inflation is fairly low, in part because, in addition to the usual costs, it provides benefits by more heavily taxing high-price sellers that inefficiently profit from exploiting the uninformed. Other applications analyse analytically and numerically changes in credit conditions and information.
CONVERSANT WIRELESS LICENSING S.A.R.L. v HUAWEI TECHNOLOGIES CO LTD
Authors:   Court of Appeal
Published: September 2019

Abstract
H1 Patents – European patents – Telecommunications – Standards essential patents – Infringement – Claims for global FRAND licences – Jurisdiction – Justiciability – Whether validity of foreign patents in issue – Stay of proceedings – Forum non conveniens – Whether China the natural and appropriate forum – Service of proceedings – Whether defendants validly served within the jurisdiction – Service out of the jurisdiction – Jurisdictional gateways – Whether good arguable case for a FRAND injunction – Property within the jurisdiction – Serious issue to be tried – Appeal to Court of Appeal
The Ambivalent U.S. Context of Reception and the Dichotomous Legal Consciousness of Unaccompanied Minors
Authors: Galli Chiara 
Published: September 2019

AbstractThis article examines the effects of contradictory U.S. immigration laws on unaccompanied minors from Central America. As children, they are considered deserving of protection, but as undocumented immigrants, they are subjected to state legal violence. Apprehended at the border, they must interact with multiple immigration agencies and finally apply for humanitarian deportation relief. Interactions in these institutional spaces teach youths about U.S. laws and behavioral norms expected of young claimants deemed deserving of humanitarian protection, which are construed in contrast to discourses that stigmatize their co-ethnics as “bad” immigrants. These interactions shape youths’ sense of belonging and commonsense understanding of the law or legal consciousness. I argue that the “legal consciousness” of unaccompanied minors is dichotomous and characterized by: (1) a combination of trust and fear in the state; (2) concurrent feelings of deservingness/rights and stigma/subordination; (3) information and misinformation about U.S. laws. This dichotomous consciousness shapes how youths claim belonging and rights in social interactions and in their applications for legal status. To signal their own belonging and deservingness, youths leverage information about their rights and normative notions about desirable teen and migrant behavior. Yet, in the process, they also inadvertently perpetuate stigmas about co-ethnics.
Diversity and evolution of New Caledonian endemic Taophila subgenus Lapita (Coleoptera: Chrysomelidae: Eumolpinae)
Authors: Platania Leonardo , Cardoso Anabela , Gómez-Zurita Jesús 
Published: September 2019

AbstractNew Caledonia is an important biodiversity hotspot, where numerous plant and animal groups show high levels of species diversity and endemicity, while facing multiple threats to their habitats. Leaf beetles in the subfamily Eumolpinae illustrate this pattern, with species estimates higher than the number of described taxa and distribution ranges that are often consistent with microendemicity. In this study, we increase the knowledge of this group by focusing on the Taophila subgenus Lapita, known from three species but here expanded to eleven with eight new species: T. atlantis sp. nov., T. hermes sp. nov., T. kronos sp. nov., T. oceanica sp. nov., T. olympica sp. nov., T. ouranos sp. nov., T. riberai sp. nov., and T. tridentata sp. nov. Additionally, we infer the evolutionary history of the group using mtDNA markers (COI and rrnS). This phylogeny and the species distribution help hypothesize a model of evolution for this lineage in the context of historical climatic and geological changes of New Caledonia.
The Tear Function in Electronic Cigarette Smokers
Authors: Md Isa Nur Amalina , Koh Poh Yi , Doraj Pavithra 
Published: September 2019

SIGNIFICANCE
Prominent ocular surface dryness and poor tear film quality among electronic cigarette (e-cigarette) smokers (or vapers) indicate potential harm to the eyes from vaping. These findings may serve as precautionary signs for e-cigarette users and exposed bystanders.

PURPOSE
Little is known about the effect of e-cigarettes on the eyes except for reported eye irritation among individuals who were exposed to e-cigarette vapors and e-liquids. This study aims to investigate the effect of vaping on ocular surface health of long-term vapers.

METHODS
Twenty-one vapers and 21 healthy nonsmokers who are all male underwent measurements of the Ocular Surface Disease Index, noninvasive tear breakup time, fluorescein breakup time, ocular surface staining, tear meniscus height, and the Schirmer test. The effect of voltage used during vaping was also evaluated against the measurements.

RESULTS
Vapers experienced moderate-to-severe eye dryness (25.0 [interquartile range, 14.6 to 43.7]) as indicated by the Ocular Surface Disease Index. Significant reductions of noninvasive tear breakup time (3.13 ± 0.97 vs. 6.57 ± 2.31 seconds; P < .0001), fluorescein breakup time (2.68 [interquartile range, 2.33 to 3.18] vs. 4.12 [3.56 to 5.07] seconds; P < .0001), and tear meniscus height (203.0 [193.0 to 225.5] vs. 235.0 [210.0 to 253.50] μm; P = .002) were noted in vapers, but the Schirmer test showed higher results (14.5 [12.0 to 17.0] vs. 8.0 [7.0 to 11.0] mm; P = .001) compared with nonsmokers. Increase in vaping voltage aggravated the dry eye symptoms and tear instability (P < .05). Higher Schirmer test result was also noted as voltage increases.

CONCLUSIONS
Vapers showed moderate-to-severe symptomatic dry eye and poorer tear film quality compared with nonsmokers. High vaping voltage may have aggravated the dry eye syndrome because of hazardous by-products from pyrolysis of the e-liquid constituents. Investigation of the ocular surface health at cellular and molecular levels is warranted to gain a deeper understanding on the effect of e-cigarette to the eyes.
Comparison of Dynamic Retinoscopy and Autorefraction for Measurement of Accommodative Amplitude
Authors: Aboumourad Rami , Anderson Heather A. 
Published: September 2019

SIGNIFICANCE
This study promotes the use of dynamic retinoscopy to obtain objective measures of accommodative amplitude (AA) in the clinical setting in lieu of the subjective push-up technique.

PURPOSE
This study compared the agreement between open-field autorefraction and a modified dynamic retinoscopy for the objective measurement of AA.

METHODS
Accommodative amplitude was measured using two objective techniques for subjects aged 5 to 60 years. Test order was randomized and monocular AA was measured as subjects viewed printed letters 0.9 mm in height with their dominant eye and distance refraction. For retinoscopy, subjects held a near rod and viewed the target at the nearest (most proximal) point of clear vision. The examiner then performed dynamic retinoscopy along the horizontal meridian and identified the physical location of neutrality of the reflex, which was converted to AA in diopters. Autorefraction was performed obtaining repeated measures of refraction beginning from a target demand of 2.5 D and increasing in discrete steps until there was no subsequent increase in accommodative response. Refractions were converted to power in the horizontal meridian and expressed as accommodation in diopters with the maximal value termed the AA. Distance overrefractions were measured for both techniques to adjust AA for any uncorrected refractive error. Difference versus mean analysis was used to compare agreement between tests.

RESULTS
The 95% limits of agreement between techniques were calculated after removal of two young outliers who responded poorly to one of the techniques. The overall mean difference for 95 subjects was 0.02 ± 0.97 D, with limits of agreement spanning −1.87 to 1.92 D. No significant linear relationship between the magnitude of the AA and the differences between techniques was observed.

CONCLUSIONS
Agreement between dynamic retinoscopy and open-field autorefraction was less than 2 D with no systematic bias, suggesting that dynamic retinoscopy may be a suitable clinical technique to measure objective AA.
An Analysis of the Optometric Applicant Pool Relative to Matriculants
Authors: Zadnik Karla , Reich Lewis N. 
Published: September 2019

SIGNIFICANCE
The interplay of applicants to optometry school and matriculants has not been explored systematically. It is vital that the profession examines these trends to ensure a viable pipeline of future doctors of optometry.

PURPOSE
The purpose of this study was to describe the demographics and academic qualifications of entering optometry classes from autumn 2010 through autumn 2018 of U.S.-based optometric institutions' application pool and matriculants (enrollees).

METHODS
Data were gathered from reports generated from accredited schools and colleges of optometry in the United States and compiled by the Association of Schools and Colleges of Optometry (publicly available) and the Optometry Centralized Application Service. Metrics included the annual number of verified applicants, the annual number of matriculants, the home region of U.S.-based applicants, and the Optometry Admission Test (OAT) performance and grade point average of verified applicants.

RESULTS
The number of verified applicants for autumn 2018 was 0.95% higher than that for autumn 2010, yet the number of matriculants in 2018 compared with 2010 increased by 11.2% with an applicant-to-matriculant ratio in 2010 of 1.53 compared with 1.39 in 2018. Grade point average and academic average OAT scores were stable from 2010 to 2018. The ratios of verified applicants with an academic average OAT score of at least 300 to matriculants were 0.87 for autumn 2018 and 0.92 for autumn 2010. The ratios of verified applicants with a grade point average of at least 3.00 to matriculants were 1.13 for autumn 2018 and 1.23 for autumn 2015.

CONCLUSIONS
Evidence supports the conclusion that the applicant pool has remained essentially flat for the last decade, whereas the number of matriculants has increased substantially; thus, the number of qualified applicants to matriculants has logically decreased. In the last 2 years, optometric programs have responded by decreasing their institution's number of matriculants to accommodate the national trends.
MicroRNA-194 promotes lineage plasticity in advanced prostate cancer
Authors: Fernandes Rayzel C. , Toubia John , Townley Scott , Hanson Adrienne R. , Dredge B. Kate , Pillman Katherine A , Bert Andrew G. , Iggo Richard , Das Rajdeep , Obinata Daisuke ,   MURAL investigators, Sandhu Shahneen , Risbridger Gail P. , Taylor Renea A. , Lawrence Mitchell G. , Butler Lisa M. , Zoubeidi Amina , Gregory Philip A. , Tilley Wayne D. , Hickey Theresa E. , Goodall Gregory J. , Selth Luke A. 
Published: September 2019

ABSTRACTMicroRNA-194 (miR-194) promotes prostate cancer metastasis, but the precise molecular mechanisms by which it achieves this are unknown. Here, by integrating Argonaute high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (Ago-HITS-CLIP) with RNA sequencing and exon-intron split analysis, we defined a 163-gene miR-194 “targetome” in prostate cancer. These target genes were predominantly down-regulated through canonical 3’UTR recognition sites and were enriched within pathways involved in cytoskeletal organisation and cell movement. In clinical prostate cancer samples, miR-194 activity was inversely correlated with the androgen receptor (AR) signalling axis. At a mechanistic level, this inverse correlation was explained by down-regulation of miR-194 expression by AR. Accordingly, miR-194 expression and activity was significantly elevated in neuroendocrine prostate cancer (NEPC), an aggressive AR-independent disease subtype. MiR-194 enhanced the transdifferentiation of prostate adenocarcinoma cells to a neuroendocrine-like state, at least in part by targeting FOXA1, a transcription factor with a key role in maintaining the prostate epithelial lineage. Importantly, a miR-194 inhibitor effectively inhibited the growth of cell lines and patient-derived organoids with neuroendocrine features. Overall, our study reveals a novel post-transcriptional mechanism regulating the plasticity of prostate cancer cells and provides a rationale for targeting miR-194 in this NEPC.
Aβ(1-42) tetramer and octamer structures reveal edge pores as a mechanism for membrane damage
Authors: Ciudad Sonia , Puig Eduard , Botzanowski Thomas , Meigooni Moeen , Arango Andres S. , Do Jimmy , Mayzel Maxim , Bayoumi Mariam , Chaignepain Stéphane , Maglia Giovanni , Cianferani Sarah , Orekhov Vladislav , Tajkhorshid Emad , Bardiaux Benjamin , Carulla Natàlia 
Published: September 2019

AbstractThe formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed as the means to explain neurotoxicity in Alzheimer’s disease (AD). It is therefore critical to characterize Aβ oligomer samples in membrane-mimicking environments. Here we present the first three-dimensional structure of an Aβ oligomer formed in dodecyl phosphocholine (DPC) micelles, namely an Aβ(1-42) tetramer. It comprises a β-sheet core made of six β-strands, connected by only two β-turns. The two faces of the β-sheet core are hydrophobic and surrounded by the membrane-mimicking environment. In contrast, the edges of the core are hydrophilic and are solvent-exposed. By increasing the concentration of Aβ(1-42), we prepared a sample enriched in Aβ(1-42) octamers, formed by two Aβ(1-42) tetramers facing each other forming a β-sandwich structure. Notably, samples enriched in Aβ(1-42) tetramers and octamers are both active in lipid bilayers and exhibit the same types of pore-like behaviour, but they show different occurrence rates. Remarkably, molecular dynamics simulations showed a new mechanism of membrane disruption in which water and ion permeation occurred through lipid-stabilized pores mediated by the hydrophilic residues located on the core β-sheets edges of the Aβ(1-42) tetramers and octamers.