bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiseptic properties of aminoadamantane derivative
Authors: Vrynchanu N. O. , Makitruk V. L. , Shalamay A. S. , Dronova M. L. , Dudikova D. M. , Suvorova Z. S. , Sharova A. O. 
Published: October 2018

Development of microbial resistance to current antimicrobial drugs created a critical need of the new antiseptics. The object of our study was phenyladamantane derivative (4-(adamantyl-1)-1-(1-aminobutyl)benzol, AM-166). The aim of the presented study was to investigate the specific activity of 4% AM-166 solution in isopropanol and 5% AM-166 solution in 76% ethanol (manufactured by PJSC SIC «Borshchahivskiy CPP») against the wide spectrum of bacteria and fungi, and effective concentrations and exposition time determination. Desinfectant/antiseptic activity was evaluated by quantitative suspension method with subsequent neutralization.
Our results showed that both solutions exhibited similar activity against gram-positive and gram-negative bacteria as well as against yeasts. Antibacterial and antifungal action was demonstrated for all investigated concentrations (initial solution, 5-fold and 10-fold dilutions), observed effect was maintained throughout the whole observation period (from 5 to 30 min).
Tested solutions in initial concentrations demonstrated fungicidal activity against A. niger. 5-fold dilution of 5% AM-166 solution in 76% ethanol was more effective than 5-fold dilution of 4% AM-166 solution in isopropanol. 10-fold dilutions of both solutions were ineffective against A. niger. The data obtained suggest the prospects of adamantane derivatives for the development of novel antiseptics.
A PAIXÃO PELA DESIGUALDADE, A INTERSECCIONALIDADE E NOVOS FEMINISMOS
Authors: Guerra Lemuel , Ferreira Lorene Dias 
Published: October 2018

Este artigo explora algumas implicações da teoria política de Rancière (2005), colocada em presença das visões em disputa no campo atual do feminismo, mais especificamente as que incluem nas suas pautas reivindicativas a abordagem interseccional – com a agregação da luta antirracismo e o especismo, em suas vertentes vegetariana e vegana. Fazemos uma interpretação rancièriana das referidas propostas, no sentido de revelar eventuais pontos de tensão a partir da sua conceitualização da democracia e da política do autor e de outros a ele relacionados.
“Is She Really the Man?”: Exploring Performativity in Twelfth Night
Authors: Andrew Lauryn , Brewster Bailee , Farr Bayley , McDonald Mae 
Published: October 2018

As modern women, in agreement with third wave feminists, we know that gender is not a binary. Did Shakespeare attempt to portray this very concept through Viola’s character in Twelfth Night? We argue that Viola is gender fluent and performs gender. Women’s subjection to men’s authority provides the motive for Viola’s disguise (Stierna). Gender is her costume, and the intentions behind that costume change throughout the play as she performs as a woman, a man, and ultimately a person.
Micas magmatiques et hydrothermaux dans l'environnement du porphyre cuprifère de Cerro Verde-Santa Rosa, Pérou
Authors: Le Bel Laurent 
Published: October 2018

On a examiné en détail le chimisme (déterminé à la microsonde électronique) des biotites et des «séricites » de l'environnement du porphyre cuprifère de Cerro Verde. L'étude montre :
— que les teneurs en AlVI et Ti des biotites, tant magmatiques qu 'hydrothermales, sont corrélées avec les températures de cristallisation estimées par des méthodes indépendantes, tandis que les rapports Mg/Fe et Mg/(Mg + Fe) sont pratiquement invariants. Cette caractéristique est interprétée en terme de fO2 ;
— que les «séricites» sont plus précisément des phengites dont les taux de solubilité des constituants céladonite et paragonite sont fixés par une phase fluide dans des conditions P, T qu'il est possible d'évaluer.
Determination of Plasma Parameters in Radio Sources of Solar Zebra-patterns Based on Relations between the Zebra-stripe Frequencies and Gyro-harmonic Numbers
Authors: Karlický Marian , Yasnov Leonid V. 
Published: October 2018

Abstract
Solar radio zebras belong to the most important radio fine structures used in diagnostics of solar flare plasmas. In the present paper, assuming the double plasma-resonance model of zebras, we study the relation between zebra-stripe frequencies and gyro-harmonic numbers. We artificially generated two possible types of zebras: the zebra with Sequence A and Sequence B, where an increase of the zebra-stripe frequency corresponds to decrease or increase of the gyro-harmonic number. Analyzing these ideal zebras, we found that the frequency ratios of the neighboring zebra stripes increase in zebras with Sequence A and decrease in zebras with Sequence B. This criterion and corresponding diagrams were applied for nine observed zebras. All these zebras were found to be with Sequence A. Then we checked and confirmed these results by using the new numerical method, where the gyro-harmonic numbers of the zebra stripes with the lowest frequency s
1 were also determined. We found that in all these zebras, the spatial scale of the magnetic field in the zebra-stripe sources was always shorter than that of the plasma density. Knowing the gyro-harmonic numbers and corresponding zebra-stripe frequencies, we determined the magnetic field and plasma density in zebra sources to be 0.84–37.31 G and 0.026 × 1010–16.03 × 1010 cm−3, respectively. Finally, we found that with increasing the gyro-harmonic number s
1, the ratio of perpendicular and parallel scales of the magnetic field and plasma density in the zebra-stripe sources also increases.
Les motivations et logiques de l’informalisation des entreprises formelles
Authors: Abaté André Modeste 
Published: October 2018

L’objectif poursuivi par ce travail exploratoire est de mettre en évidence les motivations et les modalités des transitions des entreprises du formel vers l’informel. A partir de 10 entretiens auprès des entrepreneurs et experts du monde économique au Cameroun, les résultats révèlent que l’informalisation du formel comprend deux principales modalités : informalisation totale et informalisation partielle. Par ailleurs, les motivations et logiques d’informalisation sont associées aux conséquences de l’environnement institutionnel inadapté et injuste (logique d’adaptation), au calcul stratégique des entrepreneurs (logique de « for profit ») et à la reconversion à la suite des défaillances (logique de « no-profit »).
Consommation collaborative de la génération Y : une analyse par l’approche PLS
Authors: Ait Youssef Asmaa , Koubaa Salah , Benabdallah Mounia 
Published: October 2018

La consommation collaborative, souvent associée à l’économie de partage, est un phénomène qui a connu un essor considérable avec l’âge d’Internet. Elle se déroule entre les pairs par l’intermédiaire de plateformes en ligne, et concernent des activités telles que l’échange des biens, la location, le prêt, etc. Ce papier explore, en s’appuyant théoriquement sur la théorie motivationnelle, les motivations des individus, notamment la génération Y, à participer à des pratiques de consommation collaborative. Pour ce faire, nous avons mené une analyse quantitative utilisant les données d’enquête (N = 100) recueillies auprès des étudiants de la Faculté des Sciences Juridiques Économiques et Sociales Ain Chock- Casablanca. Les résultats montrent que des facteurs intrinsèques (durabilité et jouissance) sont les principaux facteurs déterminants de l’attitude et de l’intention comportementale des individus.
Risk factors, types and outcomes of arterial ischemic stroke in Polish pediatric patients: a retrospective single-center study
Authors: Sarecka-Hujar Beata , Kopyta Ilona , Raczkiewicz Dorota 
Published: October 2018

IntroductionVarious neurological complications may occur as a consequence of arterial ischemic stroke (AIS) and have an impact on daily activity of the patients, costs of their medical care and rehabilitation. The aim of this study was to analyze risk factors, stroke symptoms and post-stroke consequences in Polish pediatric patients depending on stroke subtype.Material and methodsWe retrospectively reviewed 77 children under the age of 18 years following their first AIS. Patients were white, Polish Caucasians, recruited in the Department of Pediatric Neurology at the Medical University of Silesia in Katowice (Poland). Statistical analysis was performed using Statistica 12.0.ResultsGender differed significantly between stroke subgroups (p = 0.030). The presence of focal cerebral arteriopathy (FCA) and chronic diseases was associated with type of AIS (p = 0.003 and p = 0.050, respectively). An outcome without neurological deterioration (normal outcome) was observed in 43% of children with lacunar anterior circulation infarct (LACI). Hemiparesis was present in almost all children with total anterior circulation infarct (TACI), in two thirds of children with partial anterior circulation infarct (PACI) and in almost 50% of children with LACI or posterior circulation infarct (POCI). In every child with hemiplegia the stroke symptom evolved into hemiparesis at follow-up. Additionally, patients with a normal outcome were older at the time of AIS than those with at least one neurological consequence (OR = 0.894, p = 0.034).ConclusionsThe presence and number of neurological outcomes depend on stroke subtypes. A relation between the presence of post-stroke deficits and age at onset was observed. The odds of deficit after ischemic stroke decreases by an average of 10.6% if the child is 1 year older at the time of AIS.
Diabetes mellitus and congestive heart failure: the prevalence of congestive heart failure in patients with and without diabetes in Poland
Authors: Wierzba Waldemar , Karnafel Waldemar , Śliwczyński Andrzej , Pinkas Jarosław , Gujski Mariusz 
Published: October 2018

IntroductionDiabetes mellitus is a systemic disease and has a negative effect on the cardiovascular system. This paper aimed to present a retrospective analysis of morbidity associated with heart failure in subgroups of patients with and without diabetes in Poland in 2012.Material and methodsData from the National Health Fund were used for the study. In general, 656,937 patients with heart failure, including 281,538 males and 375,354 females, were studied. In this population, additionally, 201,043 patients with heart failure (main diagnosis) and diabetes were studied, including 82,117 males and 118,926 females.ResultsThe mean index of morbidity associated with heart failure in the whole subpopulation of diabetes patients was 9.03%; 8.42% for males and 9.50% for females. Morbidity associated with heart failure in the population of patients diagnosed with diabetes in Poland in 2012 was seven times higher compared to morbidity associated with heart failure in non-diabetes patients. Morbidity associated with heart failure in females was significantly higher compared to morbidity in males in the whole population, in both the subpopulations of patients with and without diabetes.ConclusionsDiabetes mellitus significantly increases risk of heart failure in both women and men. The risk is significantly high after the age of 60 years and higher in females.
Blood bioactive sphingolipids in patients with advanced serous epithelial ovarian cancer – mass spectrometry analysis
Authors: Knapp Paweł , Bodnar Lubomir , Błachnio-Zabielska Agnieszka , Reszeć Joanna , Świderska Magdalena , Chabowski Adrian 
Published: October 2018

IntroductionDue to the lack of highly specific and sensitive methods for diagnosing ovarian cancer at advanced stages (according to the International Federation of Gynecology and Obstetrics (FIGO) classification stage III–IV), new noninvasive biomarkers are urgently needed. This study aims to investigate how the levels of plasma bioactive sphingolipids (ceramides, sphingosine-1-phosphate, sphingosine and sphinganine) are altered in serum, erythrocytes and platelets of patients with advanced serous ovarian cancer.Material and methodsA total of 135 patients with advanced serous ovarian cancer and 159 women with normal ovarian morphology were enrolled. Plasma levels of sphingosine, sphingosine-1-phosphate, sphinganine, ceramide C14:0-Cer, C16:0-Cer, C18:1-Cer, C18:0-Cer, C20:0-Cer, C22:0-Cer, C24:1-Cer and C24:0-Cer were assessed by LC/MS/MS.ResultsPlasma concentrations of C16-Cer, C18:1-Cer and C18-Cer were significantly higher in the advanced ovarian cancer group than in the control group (1.5-fold, p = 0.021; 1.8-fold, p = 0.036 and 1.5-fold, p = 0.031, respectively). Plasma concentration of C18:1-Cer was significantly higher in erythrocytes of women with advanced serous cancer compared to the control group (p = 0.027). Plasma C16-Cer and C18:1-Cer levels and erythrocyte C18:1-Cer levels were able to distinguish patients with moderate/severe serous ovarian cancer from patients with mild ovarian cancer (AUC: 0.86, 0.898, 0.795, respectively). Plasma concentrations of C16, C18.1 and C18 significantly correlated with FIGO staging (p = 0.001, p = 0.024 and p = 0.005), and grading (p = 0.021, p = 0.021 and p = 0.033).ConclusionsPlasma concentrations of C16, C18.1 and C18 correlated with the progression of ovarian cancer (FIGO staging and grading). Plasma levels of C16-Cer and C18:1-Cer and erythrocyte C18:1-Cer levels could be used to distinguish patients with advanced serous ovarian cancer.
Constitucionalismo climático global
Authors: Contipelli Ernani 
Published: October 2018

Resumo: O presente artigo tem o objetivo de analisar a relação entre constitucionalismo global e mudança climática no contexto da ordem internacional globalizada e fragmentada. A primeira parte deste artigo dedica-se ao estudo do processo de globalização e seus efeitos na esfera de poder dos Estados-nação. Posteriormente, analisa-se a construção da definição de constitucionalismo global, considerando a fragmentação da ordem internacional e o aspecto constitutivo de alguns tratados internacionais ambientais. Na terceira parte, introduz-se o conceito de micro-constitucionalismo-global-climático e suas respectivas normas superiores, como a Convenção-Quadro das Nações Unidas sobre Mudança Climática e os demais documentos normativos criados desde o processo de tomada de decisões das Conferencias das Partes (COPs), para elaboração de um esquema de valores, princípios e regras que orientam iniciativas coordenadas em diferentes níveis de governança. Constatam-se, ainda, as possibilidades de aplicação do micro-constitucionalismo-global-climático, com base na perspectiva de sua relação com os direitos humanos e de sua atuação no campo do litigio e da migração climática.Palavras-chave: Constitucionalismo Global. Direitos Humanos. Estados-Nação. Globalização. Mudança Climática.
“Crise migratória” e a criação do imaginário social: a necessidade de desconstrução de abordagens midiáticas a luz da nova lei de migração
Authors: Tybusch Jerônimo Siqueira , Benini Agne Tybusch Francielle , Oliveira Rafael Santos de 
Published: October 2018

Resumo: Conviver com o diferente e aceitar a diferença - o cenário reportado pela mídia com relação aos refugiados não representa um panorama inclusivo e menos desigual. A mobilidade humana, além de ser uma característica constante e influente da humanidade, é hoje uma componente integral da economia mundial. No Brasil, a mídia relata uma crise migratória e conduz a população a pensar com medo e ansiedade, campos altamente nutritivos que atraem um número crescente de discursos políticos. Diante desse cenário, este artigo busca abordar a temática da globalização, ou do globalismo e seus reflexos no movimento migratório, para após verificar a influência da mídia na construção de discursos acerca da crise migratória e seus reflexos na sociedade contemporânea. Na sequência, são feitas breves considerações sobre a Lei de Migração, a Lei 13.445 de 2017, e o Estatuto do Estrangeiro à luz da Constituição Federal Brasileira de 1988.Palavras-chave: Brasil. Crise migratória. Desconstrução de abordagens midiáticas. Direito constitucional. Lei de migração.
Direitos Humanos no Estado de Direito (em crise): uma perspectiva contemporânea
Authors: Oliveira Junior José Alcebíades de , Raminelli Francieli Puntel 
Published: October 2018

Resumo:Frente à nova ordem mundial que se estabelece na contemporaneidade, o Estado tem uma diminuição de seus poderes, um enfraquecimento de sua soberania absoluta e, no campo jurídico, uma incerteza quanto à aplicação do ordenamento nacional. Existe grande expectativa de que o direito internacional consiga preencher as lacunas deixadas pelos Estados. Neste contexto, questiona-se: de que forma os direitos humanos podem ser protegidos e efetivados, e quanto o direito internacional poderá colaborar com isso? Atentar a este problema e trazer conceitos relevantes para a reflexão do tema é o objetivo central deste trabalho. Conclui-se que, embora o Estado esteja enfraquecido em seus poderes em alguns âmbitos, ele ainda exerce um papel central na proteção dos direitos humanos fundamentais dos indivíduos.Palavras-chave: Crise. Direitos Humanos. Direito Internacional. Estado Democrático de Direito. Globalização.
Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer
Authors: Amrutkar Manoj , Guttorm Sander Johannes Thorbjørnsen , Finstadsveen Anette Vefferstad , Labori Knut Jørgen , Eide Lars , Rootwelt Helge , Elgstøen Katja Benedikte Prestø , Gladhaug Ivar P. , Verbeke Caroline S. 
Published: November 2024

Neoadjuvant chemotherapy (NAT) is increasingly used for the treatment of non‐metastatic pancreatic ductal adenocarcinoma (PDAC) and is established as a standard of care for borderline resectable and locally advanced PDAC. However, full exploitation of its clinical benefits is limited by the lack of biomarkers that assess treatment response. To address this unmet need, global metabolomic profiling was performed on tumor tissue and paired serum samples from patients with treatment‐naïve (TN; n = 18) and neoadjuvant leucovorin calcium (folinic acid), fluorouracil, irinotecan hydrochloride and oxaliplatin (FOLFIRINOX)‐treated (NAT; n = 17) PDAC using liquid chromatography mass spectrometry. Differentially abundant metabolites (DAMs) in TN versus NAT groups were identified and their correlation with various clinical parameters was assessed. Metabolomics profiling identified 40 tissue and five serum DAMs in TN versus NAT PDAC. In general, DAMs associated with amino acid and nucleotide metabolism were lower in NAT compared to TN. Four DAMs—3‐hydroxybutyric acid (BHB), 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid (CMPF), glycochenodeoxycholate and citrulline—were common to both tissue and serum and showed a similar pattern of differential abundance in both groups. A strong positive correlation was observed between serum carbohydrate 19‐9 antigen (CA 19‐9) and tissue carnitines (C12, C18, C18:2) and N8‐acetylspermidine. The reduction in CA 19‐9 following NAT correlated negatively with serum deoxycholate levels, and the latter correlated positively with survival. This study revealed neoadjuvant‐chemotherapy‐induced changes in metabolic pathways in PDAC, mainly amino acid and nucleotide metabolism, and these correlated with reduced CA 19‐9 following neoadjuvant FOLFIRINOX treatment.
DDX3 participates in miRNA biogenesis and RNA interference through translational control of PACT and interaction with AGO2
Authors: Lai Ming‐Chih , Yu Yen‐Ling , Chen Chiao‐Nung , Yu Jau‐Song , Hung Hsin‐Yuan , Chan Shih‐Peng 
Published: November 2024

DDX3 is a DEAD‐box RNA helicase that plays multiple roles in RNA metabolism, including translation. We previously reported that DDX3 is required for translation of PACT, a binding partner of Dicer, suggesting a role for DDX3 in microRNA (miRNA) biogenesis and RNA interference (RNAi). Emerging evidence suggests that DDX3 plays a vital role in tumorigenesis and cancer progression, however, its underlying mechanism is still not fully understood. Here, we showed that the control of PACT by DDX3 is conserved in human cells and Caenorhabditis elegans. Using a miRNA microarray, we found that DDX3 regulates the expression of a small subset of cancer‐related miRNAs. These oncogenic miRNAs were down‐regulated by knockdown of DDX3 or PACT and up‐regulated by overexpression of DDX3 or PACT in HEK293T cells. Similar results were obtained in human cancer HCT116 and HeLa cells. Dual luciferase reporter assay showed that DDX3 and PACT are required for short hairpin RNA (shRNA)‐induced RNAi. We also performed co‐immunoprecipitation to confirm the interaction between DDX3 and AGO2, a significant component of the RNA‐induced silencing complex, supporting a role for DDX3 in the RNAi pathway. We further examined the effects of DDX3 and PACT on cell proliferation, and stable overexpression of DDX3 in HEK293 cells results in loss of contact inhibition of cell growth. Hence, we propose that DDX3 may participate in cancer development by regulating the RNAi pathway.
Incidence of and Risk of Mortality After Hip Fractures in Rheumatoid Arthritis Relative to the General Population
Authors: Jones C. Allyson , Guy Pierre , Xie Hui , Sayre Eric C. , Zhao Kai , Lacaille Diane 
Published: November 2024

ObjectiveOsteoporosis, a known complication of rheumatoid arthritis (RA), increases the risk of hip fracture, which is associated with high morbidity and mortality. Fracture risk estimates in patients with RA treated with contemporary treatment strategies are lacking. The objectives were (1) estimate age‐specific and sex‐specific incidence rates and compare the risk of hip fractures in RA relative to age‐matched and sex‐matched general population controls, and (2) compare the risk of all‐cause mortality in RA and general population controls after hip fracture.MethodsA longitudinal study of a population‐based incident cohort of patients with RA diagnosed between 1997 and 2009, followed until 2014, with age‐matched and sex‐matched controls from the general population of British Columbia, using administrative health data. Hip fracture outcomes (International Classification of Diseases, Ninth Edition, Clinical Modification [ICD‐9‐CM] codes 820.0 or 820.2; ICD‐10‐Canada code S72.0 to S72.2) and mortality at predefined intervals after fracture (in hospital, 90 days, 1‐year, 5‐year) were identified. Hip fracture incidence rates for RA and controls, and incidence rate ratios (IRRs), were calculated. Cox proportional hazards models compared hip fracture and mortality risk in RA versus controls; logistic regression compared in‐hospital mortality risk.ResultsOverall, 1,314 hip fractures over 360,521 person‐years were identified in 37,616 individuals with RA and 2,083 over 732,249 person‐years in 75,213 controls, yielding a 28% greater fracture risk in RA (IRR 1.28 [95% confidence interval 1.20–1.37]). Mean age at time of fracture was slightly younger for RA than controls (79.6 ± 10.8 vs 81.6 ± 9.3 years). Postfracture mortality risk at one‐year and five‐years did not differ between RA and general population controls. Results were similar in a sensitivity analysis including only individuals with RA who received disease‐modifying antirheumatic drugs.ConclusionPeople with RA had a greater risk of hip fractures, but no greater risk of mortality post fracture, than the general population. The relative risk of hip fractures observed was not as high as previously reported, likely reflecting better treatment of inflammation and management of osteoporosis and its risk factors.