bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vordimensionierung von vorgespannten Flachdecken
Authors: Friedrich Thomas 
Published: February 2018

AbstractIm Oktober 1995 habe ich Herrn Professor Schnell in Darmstadt anlässlich des 14. Massivbau‐Seminars „Optimierung von Decken im Hochbau“ kennengelernt. Seit diesem Zeitpunkt diskutieren wir über die Anwendung der Vorspannung im Hochbau. Als er mich 2007 anfragte, einen Lehrauftrag für vorgespannte Bauwerke des Hochbaus an der TU Kaiserslautern zu übernehmen, habe ich sehr gerne zugesagt. Seitdem verbindet uns eine intensive und anregende Zusammenarbeit, die mir viele neue Erkenntnisse gebracht hat. So war es für mich nur konsequent, ihm zu Ehren über meine Erfahrungen mit der Vorspannung im Hochbau zu berichten.Flachdecken zählen zu den Standarddecken des Hochbaus. Insbesondere bei großen Spannweiten wirkt sich das hohe Eigengewicht aufgrund des über die gesamte Fläche angeordneten Querschnitts mit konstanter Höhe nachteilig aus. Mit der Vorspannung steht ein Hilfsmittel zur Beeinflussung der Konstruktion zur Verfügung und ermöglicht dünne Deckenquerschnitte bei großen Werten für die Schlankheit. Während es mittlerweile eine Vielzahl von benutzerfreundlichen Programmen für die Berechnung von vorgespannten Flachdecken gibt, fehlen für den Entwurf die entsprechenden Hilfsmittel. Nachfolgend wird ein Konzept vorgestellt, welches es unter Berücksichtigung von konstruktiven Randbedingungen erlaubt, die erforderliche Anzahl von Spannkabeln für eine vorgespannte Flachdecke zu ermitteln. Zugleich wird auf die verschiedenen Einflüsse und deren Wirkung auf die Dimensionierung und das Ergebnis hingewiesen. Die bereitgestellten Formeln erlauben es dem Planer, einfache Programme in Tabellenform selbst zu erstellen. Dennoch werden einzelne Ergebnisse auch als Diagramm bereitgestellt.
Widerstandsklassen für Beton
Authors: Breitschaft Gerhard , Eckfeldt Lars , Hintzen Wilhelm 
Published: February 2018

AbstractVor dem Hintergrund des Klimawandels, von Umweltbetrachtungen und Diskussionen um öffentliche Investitionen ist Nachhaltigkeit zu einem Schwerpunkt der Überlegungen in der Bauplanung geworden. Die aktuellen Fortschritte bei hochdauerhaftem Beton versprechen positive Nachhaltigkeitseffekte. Ob sich diese wirklich realisieren lassen, bleibt jedoch fraglich, da die Verbesserung der Dauerhaftigkeit durch einen erhöhten Materialbedarf aufgewogen werden könnte. Hier kommt das Konzept der Widerstandsklassen für Beton im Zusammenhang mit einer performancebasierten Bemessung ins Spiel, das im Vergleich zum derzeitigen vereinfachten Dauerhaftigkeitskonzept auf Basis von Betondeckung und Expositionsklassen einen transparenteren und flexibleren Ansatz bieten könnte. Wenngleich der neue Ansatz bereits wichtige wissenschaftliche Erkenntnisse geliefert hat, müssen Aspekte wie dessen Nutzungsfreundlichkeit und Anpassungsfähigkeit sowie die Robustheit der Modelle noch eingehender behandelt werden, bevor das Konzept in die Praxis umgesetzt werden kann. Dieser Artikel bietet einen Überblick über den aktuellen Stand der Forschung und beschreibt die wichtigsten ungelösten Fragen in Bezug auf die Tragwerksplanung und Klimaneutralität.
Tunable excitation properties of ZnCdS:Mn/ZnS quantum dots for cancer imaging
Authors: Yin Naiqiang , Liu Ling , Li Peng , Zhao Shihua 
Published: February 2018

AbstractWater‐soluble ZnS:Mn quantum dots (QDs) were synthesized using a hydrothermal method with 3‐mercaptopropionic acid as stabilizer. The optical properties of ZnS:Mn QDs were thoroughly investigated by tuning the doping concentration of Mn2+ and the Zn/S precursor ratio, to obtain an optimal parameter for QDs with excellent fluorescence characteristics. ZnS:Mn QDs excited at only one wavelength, however, which seriously limited their further application. Here, a trace Cd ion was doped into a ZnS host, resulting in QD excitation covering a wide adjustable waveband. Furthermore, when a ZnS shell was coated onto the surface of the ZnCdS:Mn QDs, photoluminescence intensity and stability were further enhanced. After coupling with an anti‐CK 19 antibody, the ZnCdS:Mn/ZnS core/shell QDs were able to function by labeling cancer cells, indicating that they could be considered as a suitable bio‐probe for cells and tissue imaging.
LDL dinitrosyl iron complex: A new transferrin‐independent route for iron delivery in hepatocytes
Authors: Lewandowska Hanna , Męczyńska‐Wielgosz Sylwia , Sikorska Katarzyna , Sadło Jarosław , Dudek Jakub , Kruszewski Marcin 
Published: February 2018

AbstractIn view of the interrelations between NO, Fe, and LDL in the cardiovascular system it appears interesting to find out, if the lipoprotein particles undergo the process of iron‐nitrosylation, commonly observed for other proteins and what is the biological fate of iron‐nitrosylated LDL particles. Iron‐nitrosylated LDL preparation containing Fe(NO)2 motif (DNICLDL) was obtained and characterized for the first time. In order to test its interactions with potential target cells, DNICLDL was administered to the hepatoma HepG2 cells. The effects were referred to those induced by native LDL (nLDL) and oxidized LDL (oxLDL) particles. DNICLDL administration considerably increased total iron content in the studied cell line, but did not influence the level of calcein‐chelatable ions. DNICLDL was found to be low toxic to cells. The study suggests that DNICLDL might be a potential transducer of iron. © 2017 BioFactors, 44(2):192–201, 2018
α‐Tocopherol promotes HaCaT keratinocyte wound repair through the regulation of polarity proteins leading to the polarized cell migration
Authors: Horikoshi Yosuke , Kamizaki Kouki , Hanaki Takehiko , Morimoto Masaki , Kitagawa Yoshinori , Nakaso Kazuhiro , Kusumoto Chiaki , Matsura Tatsuya 
Published: February 2018

AbstractIn many developed countries including Japan, how to care the bedridden elderly people with chronic wounds such as decubitus becomes one of the most concerned issues. Although antioxidant micronutrients including vitamin E, especially α‐tocopherol (α‐Toc), are reported to shorten a period of wound closure, the promoting effect of α‐Toc on wound healing independent of its antioxidant activity remains to be fully elucidated. The aim of this study was to examine whether α‐Toc affects wound‐mediated HaCaT keratinocyte polarization process including the recruitment of polarity regulating proteins, leading to wound repair independently of its antioxidant activity. We investigated the effects of α‐Toc and other antioxidants such as Trolox, a cell‐permeable α‐Toc analog on the migration, proliferation, and cell polarization of HaCaT keratinocytes after wounding. We analyzed the localization and complex formation of polarity proteins, partitioning defective 3 (Par3), and atypical protein kinase C (aPKC), and aPKC activity by immunohistochemistry, immunoprecipitation analyses, and in vitro kinase assays, respectively. α‐Toc but not other antioxidants enhanced the wound closure and cell polarization in HaCaT keratinocytes after wounding. α‐Toc regulated the localization and complex formation of Par3 and aPKC during wound healing. Knockdown of aPKC or Par3 abrogated α‐Toc‐mediated promotion of the wound closure and cell polarization in HaCaT keratinocytes. Furthermore, aPKC kinase activity was significantly increased in α‐Toc‐treated cells through activation of phosphatidylinositol 3‐kinase/Akt signaling pathway. These results suggest that α‐Toc promotes HaCaT keratinocyte wound repair by regulating the aPKC kinase activity and the formation of aPKC–Par3 complex. © 2017 BioFactors, 44(2):180–191, 2018
Surgeon volume and prognosis of patients with advanced papillary thyroid cancer and lateral nodal metastasis
Authors: Kim H I , Kim T H , Choe J-H , Kim J-H , Kim J S , Kim Y N , Kim H , Kim S W , Chung J H 
Published: February 2018

Abstract

Background
Surgery is the most important treatment modality for papillary thyroid cancer (PTC). However, the relationship between surgeon volume and long-term oncological outcomes has not been explored.

Methods
Patients diagnosed with N1b PTC after initial thyroid surgery between 1 July 1994 and 31 December 2011 were eligible for inclusion in the study. Surgeons were categorized into high (at least 100 operations per year) and low (fewer than 100 operations per year) volume groups. Kaplan–Meier survival analysis according to surgeon volume was performed, and Cox proportional hazard modelling was used to estimate hazard ratios (HRs) with 95 per cent confidence intervals according to patient, tumour and surgeon factors.

Results
A total of 1103 patients with a median follow-up of 81 (i.q.r. 62–108) months were included in the study. During follow-up, 200 patients (18·1 per cent) developed structural recurrence. A high surgeon volume was associated with low structural recurrence (P = 0·006). After adjustment for age, sex and conventional risk factors for recurrence (histology, tumour size, gross extrathyroidal extension, margin status, more than 5 positive lymph nodes, radioactive iodine therapy), the adjusted HR for structural recurrence for low-volume surgeons was 1·46 (95 per cent c.i. 1·08 to 1·96), compared with high-volume surgeons. Distant metastasis (P = 0·242) and disease-specific mortality (P = 0·288) were not affected by surgeon volume.

Conclusion
Surgeon volume is associated with structural recurrence, but not distant metastasis or cancer-specific death in patients with N1b PTC. Surgeon volume is important in initial surgery for advanced PTC with extensive nodal metastasis in order to ensure curative outcome and reduce treatment-related morbidity.
Meta-analysis of metabolic surgery versus medical treatment for microvascular complications in patients with type 2 diabetes mellitus
Authors: Billeter A T , Scheurlen K M , Probst P , Eichel S , Nickel F , Kopf S , Fischer L , Diener M K , Nawroth P P , Müller-Stich B P 
Published: February 2018

Abstract

Background
This study aimed to examine the effect of metabolic surgery on pre-existing and future microvascular complications in patients with type 2 diabetes mellitus (T2DM) in comparison with medical treatment. Although metabolic surgery is the most effective treatment for obese patients with T2DM regarding glycaemic control, it is unclear whether the incidence or severity of microvascular complications is reduced.

Methods
A systematic literature search was performed in MEDLINE, Embase, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL) with no language restrictions, looking for RCTs, case–control trials and cohort studies that assessed the effect of metabolic surgery on the incidence of microvascular diabetic complications compared with medical treatment as control. The study was registered in the International prospective register of systematic reviews (CRD42016042994).

Results
The literature search yielded 1559 articles. Ten studies (3 RCTs, 7 controlled clinical trials) investigating 17 532 patients were included. Metabolic surgery reduced the incidence of microvascular complications (odds ratio 0·26, 95 per cent c.i. 0·16 to 0·42; P &lt; 0·001) compared with medical treatment. Pre-existing diabetic nephropathy was strongly improved by metabolic surgery versus medical treatment (odds ratio 15·41, 1·28 to 185·46; P = 0·03).

Conclusion
In patients with T2DM, metabolic surgery prevented the development of microvascular complications better than medical treatment. Metabolic surgery improved pre-existing diabetic nephropathy compared with medical treatment.
A workbench for motion control experiments using programmable automation controllers in industrial automation laboratory at Kongu Engineering College
Authors: Chinnasamy Jegadheesan , Ramesh Babu Kiruba Shankar , Chenniappan Maheswari , Rathinasamy Parameshwaran 
Published: February 2018

AbstractMechatronics Engineering has become an internationally recognized discipline with degree programmes offered in majority of the universities all around the world. Integrating mechanical, instrumentation, and programmable automation controller (PAC) for developing technical skills and expertise in system level integration to attain manufacturing and controller programming superiority has become the basic requirement for Mechatronics Laboratory. Divulging the graduates to servo control concept down the line to the programmable automation controller helps to gain the practical knowledge in the field of I/O interfacing, closed loop control, remote monitoring, and PLC motion control programming. Hence in this paper, a 3‐axis servo control system with HMI work bench case study has been presented to enable the graduates to learn multi‐disciplinary concepts in the field of material handling and precise position synchronous control of multi‐axis rotating system. With this work bench, applications of servo control such as electronic gearing (positioning), pick and place (material handling), and profiling (welding, machining) can be exposed to mechatronics graduates. Graduates with fundamental programming skills and apparently no‐practical experience with mechatronics systems can quickly learn how to incorporate control architectures with this work bench and prepare them to compete in Industry 4.0 environment.
Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells
Authors: Thomas Mark , Davis Tanja , Loos Ben , Sishi Balindiwe , Huisamen Barbara , Strijdom Hans , Engelbrecht Anna‐Mart 
Published: February 2018

Autophagy plays a major role in the adaptive metabolic response of cancer cells during adverse conditions such as nutrient deprivation. However, specific data that assess metabolite profiles in context with adenosine triphosphate (ATP) availability and cell death susceptibility remain limited. Human breast cancer cells, MDAMB231, and normal breast epithelial cells, MCF12A, were subjected to short‐term amino acid starvation and the cellular apoptotic and autophagic responses assessed. The role of autophagy in the control of cellular amino acid, ATP, free fatty acid, and glucose levels during amino acid starvation were compared. We demonstrate that breast cancer cells have an increased metabolic demand contributing to significant amino acid and ATP depletion in a nutrient‐poor environment. Upregulation of autophagy was important for the generation of amino acids and free fatty acids and maintenance of cellular ATP levels. In contrast to normal cells, breast cancer cells were unable to maintain the response after 12 hours of amino acid starvation. Regulation of autophagic activity in these environments had indirect consequences on cell death susceptibility. Overall, our data provide support for autophagy as an important survival mechanism capable of providing metabolic substrates when cancer cells are faced with nutrient‐deprived environments.Significance of studyThe results obtained in this study helps to expand our current knowledge on how cells respond to environmental changes; the biochemical and metabolic consequences and the physiological processes activated in response. The environmental stress applied in this study is relevant to tumour physiology, and results can be translated to cancer therapeutic and clinical research areas, ultimately assisting in the specific targeting of cancer cells while avoiding harm to normal cells.
Techniques for trans‐catheter retrieval of embolized Nit‐Occlud® PDA‐R and ASD‐R devices
Authors: Sinha Sanjay , Levi Daniel , Peirone Alejandro , Pedra Carlos 
Published: February 2018

AbstractBackgroundNit‐Occlud® (atrial septal defect) ASD‐R and (patent ductus arteriosus) PDA‐R devices are used outside the United States for percutaneous closure of the patent ductus arteriosus and atrial septal defects. When embolization occurs, these devices have been difficult to retrieve.MethodsBench simulations of retrieval of PDA‐R and ASD‐R devices were performed in a vascular model. Retrieval of each device was attempted using snare techniques or with bioptome forceps with a range of devices. The same devices were then intentionally embolized in an animal model. Retrieval methods were systematically tested in a range of sheath sizes, and graded in terms of difficulty and retrieval time.ResultsDevices that were grasped by the bioptome in the center of the proximal part of the devices were easily retrieved in both models. Bench studies determined the minimum sheath sizes needed for retrieval of each device with this method. In general sheathes two french sizes greater than the delivery sheath were successful with this technique. Three out of the four PDA‐R devices were successfully retrieved in vivo. Two were retrieved by grasping the middle of the PA end of the PDA‐R device with a Maslanka bioptome and one small PDA‐R device was retrieved using a 10 mm Snare. Four of the five ASD‐R devices were retrieved successfully grasping the right atrial ASD‐R disc or by passing a wire through the device and snaring this loop. For ASD‐R 28 and 30 mm devices, a double bioptome technique was needed to retrieve the device.ConclusionASD‐R and PDA‐R devices can be successfully retrieved in the catheterization lab. It is critical to grab the center portion of the right atrial disc of the ASD‐R device or pulmonary portion of the PDA‐R device and to use adequately sized sheathes.
Association of stent‐induced changes in coronary geometry with late stent failure: Insights from three‐dimensional quantitative coronary angiographic analysis
Authors: Zhang Bu Chun , Tu Sheng Xian , Karanasos Antonios , van Geuns Robert‐Jan , de Jaegere Peter , Zijlstra Felix , Regar Evelyn 
Published: February 2018

AbstractBackgroundThe relationship between vessel angulation and large changes in vessel geometry after stent implantation and the occurrence of stent failure still remains unclear. We sought to investigate the association of the change in the coronary bending angle after stenting and the risk for late stent failure by three‐dimensional quantitative coronary angiography (3D QCA).MethodsThe bending angle in coronary lesions that presented with late stent failure and those without stent failure was computed during the cardiac cycle, before and after stenting using a recently developed 3D QCA software.ResultsA total of 40 lesions with stent failure (cases) were successfully matched to 47 lesions without stent failure (controls).The mean duration to follow‐up coronary angiography was 1,011 days in cases and 1,109 days in the control group (P = 0.14). In stent failure, the systolic bending angle after stenting was smaller (14.45° [12.18, 17.68] versus 18.20° [14.00, 20.30], P = 0.01), while the stent‐induced change in systolic bending angle was significantly larger (4.15° [1.13, 7.20] versus 1.80° [–1.90, 4.40], P = 0.004). Multivariable logistic regression analysis suggested that systolic bending angle after stenting (odds ratio: 0.88; 95% CI: 0.79–0.99; P = 0.03), and decrease in systolic bending angle after stenting (odds ratio: 1.13; 95% CI: 1.02–1.26; P = 0.03) were predictors of stent failure.ConclusionsOur study suggests that a change in the natural tortuous course of the coronaries by stent implantation with the decrease in coronary bending angle is a potentially major contributor in stent failure.
Aqueous Red‐Emissive Probe for the Selective Fluorescent Detection of Cysteine by Deprotection/Cyclization Cascade Resulting in Large Stokes’ Shift
Authors: Kim Youngsam , Choi Minsuk , Mulay Sandip V. , Jang Minkyung , Kim Jin Yong , Lee Woo‐Hyun , Jon Sangyong , Churchill David G. 
Published: February 2018

AbstractCysteine plays a crucial role in cellular functions and in human pathologies. However, the development of cysteine probes with extremely accurate detection is still a key challenge for the field. Herein, we have fully characterized and developed a novel selective fluorescent probe: red emission, aqueous detection and large Stokes’ shift for cysteine (Reals‐C). Key in the probe synthesis is a Michael addition onto an acroylate group and subsequent intramolecular cyclization. The probe exhibits analyte detection via an intricate role set up by the leaving groups so to discriminate and form the red‐emissive analyte sensing platform (λex=471 nm, λem=637 nm) through a chemical cascade pathway. Furthermore, the sensing ability of the probe was demonstrated by both in vitro and in vivo assays. This probe enables for successfully endogenous cysteine sensing in HaCaT human keratinocytes through comparison with a commercial thiol‐sensitive probe; Reals‐C shows excellent in vivo cysteine detection in a drug‐induced animal liver injury model.
Long‐term research in ecology and evolution: a survey of challenges and opportunities
Authors: Kuebbing Sara E. , Reimer Adam P. , Rosenthal Seth A. , Feinberg Geoffrey , Leiserowitz Anthony , Lau Jennifer A. , Bradford Mark A. 
Published: February 2018

AbstractLong‐term research in ecology and evolution (LTREE) is considered fundamental for understanding complex ecological and evolutionary dynamics. However, others have argued for revision of LTREE efforts given perceived limitations in current research priorities and approaches. Yet most arguments about the benefits and failings of LTREE could be argued to reflect the views of only the limited number of scientists who have authored reports on the field, and not the wider community of ecological and evolutionary scientists. To more systematically and quantitatively assess the views of the community on LTREE contributions and future activities, we conducted and here report the results of a survey of ecological and evolutionary scientists at primarily U.S.‐based institutions, completed by 1,179 respondents. The survey objectives were to (1) identify and prioritize research questions that are important to address through long‐term, ecological field experiments and (2) understand the role that these experiments might play in generating and applying ecological and evolutionary knowledge. Almost 80% (n = 936) of respondents said that long‐term experiments had contributed “a great deal” to ecological understanding. Compared to other research approaches (e.g., short‐term, single‐site, modeling, or lab), there was overwhelming support that multi‐site, long‐term research was very important for advancing theory, and that both observational and experimental approaches were required. Respondents identified a wide range of research questions for LTREE to address. The most common topic was the impact of global change (n = 1,352), likely because these processes play out over many years, requiring LTREE approaches to fully understand. Another recurrent theme was the potential of LTREE approaches to build evolutionary understanding across all levels of ecological organization. Critical obstacles preventing some scientists from engaging in LTREE included short‐term funding mechanisms and fewer publications, whereas the longer‐term value for advancing knowledge and an individual's career were widely recognized. Substantive advances in understanding ecological and evolutionary dynamics then seem likely to be made through engagement in long‐term observational and experimental research. However, wider engagement seems dependent on a more supportive research environment and funding structure, through increased institutional acknowledgment of the contributions of long‐term research, and greater program support during the establishment and maintenance of research.