bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human CardioChimeras: Creation of a Novel ‘Next Generation’ Cardiac Cell
Authors: Firouzi Fareheh , Choudhury Sarmistha Sinha , Broughton Kathleen , Salazar Adriana , Sussman Mark A 
Published: October 2019

AbstractBackgroundCardioChimeras (CCs) produced by fusion of murine c-kit+ cardiac interstitial cells (cCIC) with mesenchymal stem cells (MSCs) promote superior structural and functional recovery in a mouse model of myocardial infarction (MI) compared to either precursor cell alone or in combination. Creation of human CardioChimeras (hCC) represents the next step in translational development of this novel cell type, but new challenges arise when working with cCICs isolated and expanded from human heart tissue samples. The objective of the study was to establish a reliable cell fusion protocol for consistent optimized creation of hCCs and characterize fundamental hCC properties.Methods and ResultsCell fusion was induced by incubating human cCICs and MSCs at a 2:1 ratio with inactivated Sendai virus. Hybrid cells were sorted into 96-well microplates for clonal expansion to derive unique cloned hCCs, which were then characterized for various cellular and molecular properties. hCCs exhibited enhanced survival relative to the parent cells and promoted cardiomyocyte survival in response to serum deprivation in vitro.ConclusionsThe generation of hCC is demonstrated and validated in this study, representing the next step toward implementation of a novel cell product for therapeutic development. Feasibility of creating human hybrid cells prompts consideration of multiple possibilities to create novel chimeric cells derived from cells with desirable traits to promote healing in pathologically damaged myocardium.Clinical Perspective“Next generation” cell therapeutics will build upon initial findings that demonstrate enhanced reparative action of combining distinct cell types for treatment of cardiomyopathic injury.Differential biological properties of various cell types are challenging for optimization of delivery, engraftment, persistence, and synergistic action when used in combination.Creation of a novel hybrid cell called a CardioChimera overcomes limitations inherent to use of multiple cell types.CardioChimeras exhibit unique properties relative to either parental cell anticipated to be advantageous in cellular therapeutic applications.CardioChimeras have now been created and characterized using cells derived from human heart tissue, advancing initial proof of concept previously demonstrated with mice.CardioChimeras represent an engineered solution that can be implemented as a path forward for improving the outcome of myocardial cell therapy.
Corporate sustainability management under market uncertainty
Authors: Liu Honglei , Kim Sang Jin , Wang Huanzhang , Kim Kyung Hoon 
Published: October 2019

Purpose
The purpose of this paper is to understand how market uncertainty affects sustainability management for long-term survival and growth.

Design/methodology/approach
Structural equation modeling is applied to evaluate the research model using data from a survey of 210 firms in China.

Findings
Empirical findings show that market uncertainty encourages entrepreneurship, which is an impetus for sustainability management. Economic and environmental responsibility positively affects balanced scorecard, but social responsibility does not.

Research limitations/implications
The study results show that economic and environmental responsibility is essential for success, but social responsibility appears to lack effect. Therefore, future research might further explore why social responsibility fails to enhance corporate performance.

Practical implications
When firms consider sustainability management for long-term survival and growth, they should not only strive to grow regional economic benefits but also adhere to environmental regulations and protect the local ecosystem.

Originality/value
This study observes how market uncertainty, entrepreneurship and corporate sustainability (economic, environmental and social responsibility) affect the overall performance of firms in China.
Overcoming fears: a pathway to publishing for early career researchers
Authors: Drosou Nafsika , Del Pinto Monia , Al-Shuwaili Mohammed A. , Goodall Susie , Marlow Elisabeth 
Published: October 2019

Purpose
The purpose of this paper is to present reflections of five early career researchers on the challenges of journal publishing and how to tackle them.

Design/methodology/approach
The authors attended a participatory workshop on demystifying academic publications. Working individually and in groups the authors shared, discussed, analysed, visualised and ranked perceived challenges and opportunities concerning academic publishing. The authors then delved into the existing literature on the subject. Following their enhanced understanding of the area, the authors reflected on the experience and learnings.

Findings
Personal confidence relating to the development of a scholarly identity was found to be a critical factor in the attitude towards journal publishing. Supervisory and peer support, accessibility to journal editors, as well as opportunities to reflect on the writing, publishing and peer review processes through participatory workshops and writing groups, were deemed more effective than formal and conventional guidance schemes.

Research limitations/implications
This work adds to the available literature regarding the issue of academic publishing for PhD students and early career researchers.

Originality/value
The paper contributes to a deeper understanding of issues surrounding publishing apprehension, by laying out thoughts that are seldom expressed.
The language of teacher agency in an eighth grade ELA classroom
Authors: Loretto Adam 
Published: October 2019

PurposeThis paper aims to apply ecological models of agency to understand factors influencing how an eighth grade English language arts (ELA) teacher enacted agency in four moments in the classroom. It focuses on how his language in relation to his instructional choices reflected messaging to his students regarding the learning he intended from his ELA instruction.Design/methodology/approachThe paper applies an existing framework (Biestaet al., 2015, 2017), adding Bakhtin (1981) understandings of language, to classroom discourse supplemented by teacher interviews and other data sources. In looking across these data sources, the paper traces the influence of past factors (i.e. the teacher’s personal and professional history) and future orientations (i.e. goals established in standards and the teacher’s goals for his students) on present instructional decisions. The teacher’s language in the classroom becomes a primary focus for this study, as it reveals the ways in which he drew on specific resources in the messages in his instruction.FindingsIn each moment, the teacher’s language could be shown to have motivation in a variety of factors. While influenced by external factors such as the common core standards and standardized assessments, the teacher often enacted agency out of his personal beliefs about making learning personally meaningful for students as grounded in his personal and professional history. Exceptions to this pattern, especially regarding preparing students for writing tests on state assessments, less frequently relied on the language of finding meaning in the learning.Originality/valueThis paper builds on studies of ELA teacher agency through the development of methodology related to an ecological model of agency and Bakhtinian concepts of language focused on the discourse of the classroom. It contributes to understanding the factors at study in an ELA teacher’s instructional agency, which can help teachers and researchers further develop frameworks for describing and assessing the practice of agency in the profession.
The role of tie strength in bank credit card referral reward programs with scarcity messages
Authors: Song Chanho , Wang Tuo , Brown Haakon T. , Hu Michael Y. 
Published: October 2019

Purpose
The purpose of this paper is to investigate how referral reward programs (RRPs) utilizing scarcity messages influence bank credit holders’ referrals to and adoptions by close or distant friends.

Design/methodology/approach
A 2×2 experiment is implemented with 760 consumers solicited through Amazon’s Mechanical Turk worker panel. Logit transformation and general linear models are used to test the proposed hypotheses.

Findings
Results showed that offering RRPs with limited available referrals (quantity scarcity) increases the overall number of referrals to and adoptions by close and distant friends. The percent of strong ties also increases with RRPs. As quantity scarcity is relaxed, the percentages of referrals to and adoptions by close friends decrease.

Originality/value
The inclusion of tie strength with scarcity framing greatly enhances our understanding of the effectiveness of RRPs for bank credit cards. To the authors’ knowledge, this is the first research attempt on this topic.
What is the core essence of small city boutique hotels?
Authors: Loureiro Sandra Maria Correira , Rita Paulo , Sarmento Eduardo Moraes 
Published: October 2019

PurposeThe purpose of this study is to contribute with new insights into the nature, dimensionality and measurement of the core essence of the small city boutique hotel (SCBH), something which has been limited in the literature to date. It further explores the conceptual relationships of SCBH with other constructs, providing greater understanding of the nature of these specific conceptual associations and showing that the SCBH scale exhibits construct validity.Design/methodology/approachThis study followed the Churchill’s paradigm to methodologically design the study and develop the scale. Based on an exploratory qualitative inquiry (one focus group and ten interviews) and quantitative assessment (two surveys), support was found for a three-dimensional scale.FindingsResults support the proposed measures of the scale (dream, hospitality and style) in terms of construct, convergent, discriminate, nomological and predictive validity. The findings also suggest that while authenticity acts as a SCBH antecedent, pleasant arousal and preference represent SCBH consequences.Originality/valueBy developing and validating a SCBH scale for city destination, this study addresses an identified literature gap. Specifically, it conceptualizes SCBH as guests’ perception about core characteristics of SCBHs located in the city.
The role of online leadership in open collaborative innovation
Authors: Mu Wen , Bian Yiyang , Zhao J. Leon 
Published: October 2019

Purpose
The purpose of this paper is to investigate the roles of online leadership in open collaborative innovation success by extending functional leadership theory in the context of open source projects.

Design/methodology/approach
This study uses negative binomial regression models to empirically test the proposed hypotheses with samples of blockchain open source projects on GitHub.

Findings
The results indicate that task-oriented leadership behaviors in forms of technical contributions have little influence on open collaborative innovation success; relation-oriented leadership behaviors embedded in internal social capital and external social capital contribute to open collaborative innovation success prominently. Furthermore, the joint effects of technical contributions, internal social capital and community commitment with openness orientation are positively significant on open collaborative innovation success, respectively.

Practical implications
For leaders and participants of open collaborative innovation projects, they should attach importance to both leadership behaviors and the joint effects with openness orientation so as to make informed decisions.

Originality/value
This study offers a new fine-grained framework of open collaborative innovation success by investigating specific dimensions of task-oriented and relation-orientated leadership behaviors, as well as their joint effects with openness orientation.
Risk management in perishable food distribution operations
Authors: Wang Yingchao , Yang Chen , Hou Hanpo 
Published: October 2019

PurposeThe purpose of this paper is to predict or even control the food safety risks during the distribution of perishable foods. Considering the food safety risks, the distribution route of perishable foods is reasonably arranged to further improve the efficiency of cold chain distribution and reduce distribution costs.Design/methodology/approachThis paper uses the microbial growth model to identify a food safety risk coefficient to describe the characteristics of food safety risks that increase over time. On this basis, with the goal of minimizing distribution costs, the authors establish a vehicle routing problem with a food safety Risk coefficient and a Time Window (VRPRTW) for perishable foods. Then, the Weight-Parameter Whale Optimization Algorithm (WPWOA) which introduces inertia weight and dynamic parameter into the native whale optimization algorithm is designed for solving this model. Moreover, benchmark functions and numerical simulation are used to test the performance of the WPWOA.FindingsBased on numerical simulation, the authors obtained the distribution path of perishable foods under the restriction of food safety risks. Moreover, the WPWOA can significantly outperform other algorithms on most of the benchmark functions, and it is faster and more robust than the native WOA and avoids premature convergence.Originality/valueThis study indicates that the established model and the algorithm are effective to control the risk of perishable food in distribution process. Besides, it extends the existing literature and can provide a theoretical basis and practical guidance for the vehicle routing problem of perishable foods.
Evaluating the impact of hedonism on investment choices in India
Authors: Singla Harish Kumar , Hiray Amit 
Published: October 2019

Purpose
The purpose of this paper is to find the effect of the hedonism value on the investment preference in India.

Design/methodology/approach
Based on the literature review, a measurement model is developed to measure hedonism. Further, the effect of hedonism on investment choices of an individual and the impact of age, gender and income level on investment choices and on hedonism are also measured through a structural equation model (SEM).

Findings
The study finds that the measurement model is reliable, and all five items, that is an exciting life, happiness, pleasure, social recognition and a comfortable life, are an appropriate measure of hedonism. The study finds that hedonists prefer to invest in stock market-related instruments and real estate. The study also ascertains that age and income affect the hedonism value negatively. The findings also indicate that women prefer to invest in fixed income instruments and men prefer to invest in stock market-related instruments. As people grow in age, they prefer to invest in fixed-income instruments and gold as a hedge, thus avoiding risky investments.

Research limitations/implications
The study does not include education and financial literacy of individuals in the model, rather controls these factors by selecting a sample where the minimum educational qualification of the respondent is graduation.

Practical implications
It is assumed that the values that drive an individual have the potential to influence his/her investment choices. Therefore, the study advises the firms offering investment services to their clients to ensure that apart from studying the demographic and risk profile of individuals, they also assess their value system. This can help them target their customers more precisely and serve them better.

Originality/value
The study is perhaps the first attempt to find the effect of personal values (specifically hedonism) on investment choices made by individuals, through the development of an SEM.
Commentary on “Afraid to leave the house: issues leading to social exclusion and loneliness for people with a learning disability”
Authors: Harrison Rachel A. 
Published: October 2019

Purpose
The purpose of this paper is to provide a commentary on, “Afraid to leave the house: issues leading to social exclusion and loneliness for people with a learning disability”.

Design/methodology/approach
This paper considers the impacts of cuts to services, support and care that people with learning disabilities experience and the effects these cuts can have on social inclusion and positive social networks. Ways in which these impacts can be overcome are considered.

Findings
Listening to the voices of people with learning disabilities can provide opportunities for positive change which meet the needs of people with learning disability and society more widely.

Originality/value
The commentary uses evidence to consider the effects of cuts to services on the lives of people with learning disability and to provide possible solutions.
Perceived needs and difficulties in meal preparation of people living with traumatic brain injury in a chronic phase: Supporting long‐term services and interventions
Authors: Dubuc Érika , Gagnon‐Roy Mireille , Couture Mélanie , Bier Nathalie , Giroux Sylvain , Bottari Carolina 
Published: October 2019

IntroductionTraumatic brain injury (TBI) is a chronic medical condition with life‐long consequences. Meal preparation is one of the most significant activities impacted by TBI even after more than 10 years post‐trauma. However, substantial gaps exist in our understanding of how exactly it is affected. This study examines the perceived needs and difficulties regarding meal preparation in individuals with severe TBI living in the community. This is done in an effort to justify long‐term community‐based interventions offered to the TBI population with regard to a task involving many safety issues.MethodsThe study used a descriptive qualitative design where five adults (28–50 years old) living with a severe TBI (9–37 years post‐injury) were interviewed. Data analysis was completed using an inductive method.ResultsParticipants living alone were all involved in meal preparation to diverse levels. Only two participants lived with a family member. Six categories of perceived needs were identified, of which two emerged as priorities: (i) Need for recipes to be compatible with cognitive abilities, knowledge and energy level to optimise motivation and (ii) Need to adapt complexity of grocery shopping to cognitive abilities and knowledge. The main difficulty expressed by participants was to manage their motivation to cook when tired, as it tends to diminish and fade when the person is exhausted.ConclusionMany situations were considered difficult for our participants, which calls for adaptation of the tasks and of their environment. Considering these unmet needs in the interventions offered will help individualise follow‐up and ultimately optimise the social integration of individuals living with severe TBI.
LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR‐574‐5p
Authors: Tong Rui , Zhang Jingru , Wang Chunyan , Li Xuemei , Yu Tingting , Wang Ling 
Published: October 2019

AbstractDysregulation of long non‐coding RNA papillary thyroid carcinoma susceptibility candidate 3 (lncRNA PTCSC3) has been found to correlate with various types of cancers. Quantitative RT‐PCR showed a down‐regulation of PTCSC3 in cervical cancer tissues compared with normal cervical tissues. The present study aimed to investigate the role of lncRNA PTCSC3 in cervical cancer and the underlying mechanisms. PTCSC3 was overexpressed in cervical cancer cell lines C‐33A and Hela by transfection with pcDNA3.1‐lncRNA PTCSC3 expressing plasmid. Overexpression of lncRNA PTCSC3 inhibited cell proliferation, induced cell cycle arrest, and suppressed cell invasion and migration using CCK8 assay, flow cytometry, Transwell assay and wound healing examination, respectively. Western blotting analysis showed that PTCSC3 overexpression decreased the expression of cyclinD1, matrix metalloproteinases 9 (MMP9), N‐cadherin and β‐catenin and increased E‐cadherin expression. Further, PTCSC3 negatively regulated miR‐574‐5p expression and dual‐luciferase assay verified the binding activity between miR‐574‐5p and lncRNA PTCSC3. Enforced up‐regulation of miR‐574‐5p abolished the inhibitory effect of lncRNA PTCSC3 on cervical cancer cell proliferation, invasiveness and mobility. Taken together, lncRNA PTCSC3 inhibited cell growth and metastasis via sponging miR‐574‐5p in cervical cancer. Therefore, we demonstrate the tumour‐suppressive function of lncRNA PTCSC3 in cervical cancer and suggest that PTCSC3 is a potential therapeutic target for cervical cancer.
Sauchinone inhibits angiotensin II‐induced proliferation and migration of vascular smooth muscle cells
Authors: Wang Ying , Li Xiaoming , Huang Xuying , Ma Sirui , Xing Yue , Geng Xiaoying , He Xu 
Published: October 2019

AbstractHypertension is a common type of cardiovascular disease that remains a major cause of death in the world. Vascular remodelling is an important complication of hypertension, and vascular smooth muscle cells (VSMCs) play a major role in vascular remodelling. Sauchinone is one of the active lignins which has been found to possess vascular protective effects. However, the functional role of sauchinone in hypertension has not been investigated. The aim of this study was to evaluate the role of sauchinone in the angiotensin II (Ang II)‐induced vascular remodelling model in VSMCs. The results showed that treatment of sauchinone inhibited Ang II‐induced VSMCs proliferation and migration in VSMCs. Sauchinone treatment suppressed the reactive oxygen species (ROS) production and NADPH oxidase (NOX) activity in Ang II‐induced VSMCs. The inhibitory effects of Ang II on expressions of VSMCs phenotype markers including α‐smooth muscle actin (α‐SMA), calponin, osteopontin were mitigated by sauchinone treatment. Furthermore, sauchinone inhibited Ang II‐induced over‐activation of TGF‐β1/Smad3 signalling pathway in VSMCs. Taken together, this study identified sauchinone as a potential agent for preventing vascular remodelling in hypertension.
Stroke‐prone spontaneously hypertensive rats have reduced hydroxysteroid 17‐β dehydrogenase 7 levels for low cholesterol biosynthesis
Authors: Matsuoka Hiroshi , Uchino Yuka , Choshi Mayuko , Nakamura Tetsuya , Michihara Akihiro 
Published: October 2019

AbstractReduced serum cholesterol content was recently reported to be one of the factors responsible for cerebral haemorrhage. Stroke‐prone spontaneously hypertensive rats (SHRSP) are known to have lower serum cholesterol content than normotensive Wistar‐Kyoto rats (WKY). We previously reported that lower levels of mevalonate pyrophosphate decarboxylase (MPD) and squalene epoxidase (SQE), which are associated with cholesterol biosynthesis in the liver, are involved in the low serum cholesterol content in SHRSP. Here, we investigate the levels of sterol 14‐demethylase (CYP51), methylsterol monooxygenase (SC4MOL), and hydroxysteroid 17‐β dehydrogenase 7 (HSD17B7), which contribute to the cholesterol synthesis pathway in the conversion of lanosterol to zymosterol, in SHRSP and WKY. The HSD17B7 mRNA levels in the liver of SHRSP were markedly lower than those in WKY, whereas no significant differences were observed in CYP51 and SC4MOL levels in the two types of rats. The relative levels of protein, heteronuclear RNA, and mRNA of HSD17B7 were also significantly lower in SHRSP than in WKY. The degradation rates of HSD17B7 were the same in SHRSP and WKY. The protein levels of HSD17B7 were not significantly reduced in tissues other than the liver, including the brain, lung, heart, spleen, kidney, and testis, in SHRSP. Moreover, HSD17B7 activity was significantly lower in SHRSP than in WKY. Thus, our results indicated that low protein levels and activity of HSD17B7 are responsible for the reduced cholesterol content in SHRSP, indicating that HSD17B7, along with MPD and SQE, is involved in the decreased cholesterol synthesis in the liver of SHRSP.