bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Hybrids of Pyrazolidinedione and Benzothiazole as TZD Analogues. Rationale Design, Synthesis and In Vivo Anti-Diabetic Evaluation
Authors: Haroun Michelyne 
Published: May 2019

Background:
The development of new classes of blood glucose–lowering medications
has increased the number of treatment opportunities available for type 2 diabetes. Nevertheless,
long term complicated treatments and side effects of available antidiabetic therapies have urged
huge demands for effective affordable anti-diabetic agents that can lessen negative health consequences.
In this sense, the exploration of alternative medicinal remedies associated with new significant
antidiabetic efficiencies with minimized adverse effects is an active domain of research.

Objective:
The aim of this study was to synthesize a series of benzothiazole-pyrazolidinedione hybrids
and evaluate their antidiabetic activity along with molecular docking and in silico analysis.

Methods:
The hybrids were synthesized by a multi-step synthesis and were further subjected for in
vivo anti-hyperglycemic assessment on rat models of type II diabetes. Molecular modelling study
was undertaken against peroxisome proliferator-activated receptor γ (PPARγ) to highlight possible
key interactions.

Results:
Docking studies revealed that appropriate substituents on benzothiazole ring interacted
favorably with the hydrophobic Ω-pocket of PPARγ binding site resulting in improving their antihyperglycemic
activity. All the synthesized hybrids manifested promising anti-hyperglycemic potency.
Excitingly, 5a, 5b and 5c were even more potent than the standard drug.

Conclusion:
The newly synthesized hybrids can be considered as a new class of antidiabetic
agents and this study provided useful information on further optimization.
Adverse Drug Reaction (ADR) as a Cause of Hospitalization at a Government Hospital in Saudi Arabia: A Prospective Observational Study
Authors: Alayed Nouf , Alkhalifah Bushra , Alharbi Munirah , Alwohaibi Naief , Farooqui Maryam 
Published: May 2019

Background:
ADRs represent a substantial burden on health care resources worldwide and are
considered as one of the leading causes of morbidity and mortality which significantly affects hospitalization
rates. However, ADR related hospital admissions are not well explored in Saudi Arabia.

Objectives:
The current study aims to evaluate ADR-related admissions at King Saud Hospital, Unaizah,
Qassim, Saudi Arabia.

Method:
A prospective, observational study was conducted at King Saud Hospital Unaizah. Over a period
of 6 months, patients above 12 years of age who visited the Emergency Department (ED) with an ADR
were included in this study. The investigators collected patient data by reviewing the patient's medical records
and the ED records for admission. The Naranjo algorithm was used to assess the causality of the suspected
ADR, and Hartwig’s Severity Assessment Scale was used to assess the severity of the ADR.

Results:
Out of 4739 admissions to the wards, 38 (0.801%) were related to an ADR. The majority of patients
were male (52.6%), with a mean age of ± 49.08 years. The total length of hospital stay was 565 days
with a mean of ± 14.87 days. The causality assessment shows that 35 (92.1%) cases were probable ADRs,
whereas 3 (7.9%) cases were possible ADRs. Moreover, the severity assessment showed that 6 (15.1%)
cases were mild, and 27 (71.1%) and 5 (13.2%) cases were moderate and severe, respectively. In regard to
the outcome of patients, most patients recovered after the ADR, and 2 ADRs resulted in the death of the patient.

Conclusion:
Our study shows that ADRs as a cause of hospitalization in Qassim population is considerably
low. However, ADRs may contribute to morbidity and mortality and result in a considerable financial burden.
Sodium Zirconium Cyclosilicate among Individuals with Hyperkalemia
Authors: Spinowitz Bruce S. , Fishbane Steven , Pergola Pablo E. , Roger Simon D. , Lerma Edgar V. , Butler Javed , von Haehling Stephan , Adler Scott H. , Zhao June , Singh Bhupinder , Lavin Philip T. , McCullough Peter A. , Kosiborod Mikhail , Packham David K. ,   on behalf of the ZS-005 Study Investigators
Published: May 2019

Background and objectives
Oral sodium zirconium cyclosilicate (formerly ZS-9) binds and removes potassium via the gastrointestinal tract. Sodium zirconium cyclosilicate–associated restoration and maintenance of normokalemia and adverse events were evaluated in a two-part, open label, phase 3 trial.

Design, setting, participants, & measurements
In the correction phase, adult outpatients with plasma potassium ≥5.1 mmol/L (i-STAT Point-of-Care) received sodium zirconium cyclosilicate 10 g three times daily for 24–72 hours until normokalemic (potassium =3.5–5.0 mmol/L). Qualifying participants entered the ≤12-month maintenance phase and received sodium zirconium cyclosilicate 5 g once daily titrated to maintain normokalemia without dietary or medication restrictions. Prespecified primary end points were restoration of normal serum potassium values (3.5–5.0 mmol/L) during the correction phase and maintenance of serum potassium ≤5.1 mmol/L during the maintenance phase. Adverse events were assessed throughout.

Results
Of 751 participants, 746 (99%) achieved normokalemia during the correction phase (mean serum potassium =4.8 mmol/L; 95% confidence interval, 4.7 to 4.8) and entered the maintenance phase; 466 (63%) participants completed the 12-month trial. Participants were predominantly white, men, and age ≥65 years old; 74% had an eGFR<60 ml/min per 1.73 m2, and 65% used renin-angiotensin-aldosterone system inhibitors. Mean time on sodium zirconium cyclosilicate was 286 days. Mean daily sodium zirconium cyclosilicate dose was 7.2 g (SD=2.6). Over months 3–12, mean serum potassium was 4.7 mmol/L (95% confidence interval, 4.6 to 4.7); mean serum potassium values ≤5.1 and ≤5.5 mmol/L were achieved by 88% and 99% of participants, respectively. Of 483 renin-angiotensin-aldosterone system inhibitor users at baseline, 87% continued or had their dose increased; 11% discontinued. Among 263 renin-angiotensin-aldosterone system inhibitor–naïve participants, 14% initiated renin-angiotensin-aldosterone system inhibitor therapy. Overall, 489 (66%) participants experienced adverse events during the maintenance phase, and 22% experienced a serious adverse event. Of eight (1%) deaths, none were considered related to sodium zirconium cyclosilicate. Nine (1%) and 34 (5%) participants experienced serum potassium <3.0 and 3.0–3.4 mmol/L, respectively.

Conclusions
After achieving normokalemia, individualized once daily sodium zirconium cyclosilicate was associated with maintenance of normokalemia without substantial renin-angiotensin-aldosterone system inhibitor changes for ≤12 months.
Auditor Response to Negative Media Coverage of Client Environmental, Social, and Governance Practices
Authors: Burke Jenna J. , Hoitash Rani , Hoitash Udi 
Published: May 2019

SYNOPSIS
We use new data to examine auditor response to negative media coverage of client environmental, social, and governance (ESG) practices. This coverage can be indicative of an increased risk of material misstatement, which is an important assessment in client retention and pricing decisions. Specifically, media criticism can threaten a client's financial condition, as well as reveal management effectiveness and integrity issues that are further compounded by negative attention and related financial problems. We therefore predict that auditors will notice and incorporate media-provided ESG information in their risk response, which has not been examined by prior research. Supporting this prediction, we find that ESG-related negative media coverage of an audit client is associated with a higher likelihood of auditor resignation and increased audit fees. This response is incremental to the issues that underlie this media coverage. Overall, these findings identify an additional economic incentive for companies to avoid poor ESG practices.
PELATIHAN SHUTTLE TIME BULUTANGKIS DI SD NEGERI 91 PEKANBARU
Authors: Gazali Novri , Cendra Romi 
Published: May 2019

Abstrak Provinsi Riau merupakan salah satu Provinsi yang sedang gencar-gencarnya melakukan pembinaan di berbagai cabang olahraga di antaranya adalah bulutangkis. Salah satu cara Pengurus PBSI (Persatuan Bulutangkis Seluruh Indonesia) Provinsi Riau meningkatkan dan mensosialisasikan olahraga bulutangkis yaitu dengan cara masuk ke sekolah-sekolah dan mengadakan kegiatan shuttle time di sekolah dasar. Shuttle time adalah suatu program kepelatihan bulutangkis untuk para Guru-Guru olahraga sekolah dasar dan anak-anak usia dini dalam rangka pengembangan olahraga bulutangkis di sekolah dasar seluruh Indonesia. Pelatihan ini bertujuan untuk memasyarakatkan olahraga bulutangkis dan meningkatkan minat siswa dalam bermain bulutangkis, dan diharapkan dengan diadakannya kegiatan pengabdian masyarakat di SD Negeri 91 Rumbai Pekanbaru ini akan muncul bibit-bibit atlet bulutangkis masa depan khususnya dari Provinsi Riau. Kegiatan pengabdian masyarakat ini dilaksanakan di SD Negeri 91 Kecamatan Rumbai Kota Pekanbaru dengan peserta adalah Guru Penjaskes yang berjumlah 2 orang dan siswa SD Negeri 91 Pekanbaru yang berjumlah 22 orang. Materi yang akan disampaikan berisi tentang bagaimana belajar bulutangkis dengan benar dan bagaimana agar siswa-siswi di SD menyukai dan menyenangi olahraga bulutangkis. Metode yang diberikan berupa praktek dan tes keterampilan bermain bulutangkis siswa di SD Negeri 91 Pekanbaru.. Kata Kunci: Pelatihan Shuttle Time, Bulutangkis. Abstract Riau Province is one of the provinces that are incessant-incessant to coaching in various sports such as badminton. One of the Board's ways PBSI (Persatuan Bulutangkis Seluruh Indonesia) Riau Province improves and socializes badminton sport that is by way of entering to school and holding activity of shuttle time in elementary school. Shuttle time is a badminton coaching program for elementary school and early childhood sports teachers in order to develop badminton sport in elementary school all over Indonesia. This training is aimed to promote badminton sport and increase students' interest in badminton game, and it is expected that with community service activity in SD Negeri 91 Pekanbaru will emerge seeds of future badminton athletes especially from Riau Province. This community service activity was carried out in SD Negeri 91 Rumbai sub-district Pekanbaru with the participants were Teacher Penjaskes which amounted to 2 people and students SD Negeri 91 Pekanbaru City which amounted to 22 people. The material will be delivered about how to learn badminton properly and how to make the students in elementary school like and enjoy badminton sport. The methods given in the form of practice and test of badminton students play in SD Negeri 91 Pekanbaru. Keywords: Shuttle Time Training, Badminton.
PENGEMBANGAN ANGKUTAN JALAN PERINTIS DI KABUPATEN PELALAWAN PROVINSI RIAU
Authors: Nurdjanah Nunuj 
Published: May 2019

Pemerintah Provinsi Riau berharap semua daerah di provinsi Riau harus terhubung dengan daerah yang lain agar ekonomi bisa tumbuh dengan baik. Selain dengan membangun jalan dan jembatan keterhubungan antar daerah juga perlu didukung dengan adanya penyediaaan angkutan salah satunya dengan penyediaan angkutan jalan perintis. Penelitian ini dimaksudkan untuk menganalisis kebutuhan pengembangan angkutan jalan perintis di Provinsi Riau, sebagai bahan masukan untuk mewujudkan pengembangan aksesbilitas dan konektivitas transportasi jalan guna membuka daerah terisolasi atau kurang berkembang di Provinsi Riau. Dalam penelitian ini wilayah studi sebagai sampel adalah usulan rute untuk trayek Pangkalan Kerinci-Teluk Meranti di Kabupaten Pelalawan. Trayek ini sudah terhubung dengan akses jalan provinsi, terdapat potensi daerah yang cukup baik yaitu perkebunan CPO, serta destinasi wisata Ombak Bono di Pulau Muda. Berdasarkan hasil analisis dengan menggunakan metode multikriteria analisis, dapat disimpulkan bahwa angkutan jalan perintis untuk trayek Pangkalan Kerinci-Teluk Meranti cukup dapat dikembangkan dan perlu didukung dengan pengembangan fasilitas lainnya seperti penyediaan tempat henti, perlengkapan jalan, dan pelebaran jalan desa di wilayah studi. Selain itu juga perlu pengembangan dan meningkatkan pengelolaan destinasi wisata Sungai Kampar dimana terjadi fenomena Ombak Bono, sehingga bisa meningkatkan kunjungan wisatawan domestik maupun mancanegara yang menjadi potensial demand angkutan jalan perintis, maupun angkutan umum jalan komersial di masa yang akan datang.
Good Living Goals An alternative proposal to the Sustainable Development Goals
Authors: Hidalgo-Capitán Antonio Luis , García-Álvarez Santiago , Cubillo-Guevara Ana Patricia , Medina-Carranco Nancy 
Published: May 2019

In this article we make a deconstruction of the Sustainable Development Goals (SDGs) through différance technique, to identify the main inconsistencies of the SDGs with respect to their purpose of contributing to the improvement of the well-being of humanity, from the perspective of transmodern trans-development. We understand this concept as that way of life that allows human beings to coexist in harmony with other beings of nature, with other human beings and with ourselves. From this analysis, we concluded that the development implicit in the SDGs is really a model of unsustainable maldevelopment, based on coloniality-patriarchality-heteronormality of power-knowing-being, on capitalism and on anthropocentrism. And that has as consequences a global apartheid and an imperial way of life.
Later, we propose that, if the concept of good living emerged as an alternative to the concept of sustainable development, in the face of the international cooperation agenda of the SDGs, we can also make an alternative global agenda based on the Good Living Goals (GLGs). Thus, based on a normative research, from two discussion groups and a survey of experts, this section includes a proposal for GLGs, articulated in 3 general goals and 21 specific goals. All these goals would be aimed at achieving the three harmonies that should characterize global good living: biocentric sustainability, which would reflect harmony with all beings of nature; social equity, which would reflect harmony with all human beings; and personal satisfaction, which would reflect harmony with oneself.
PENGEMBANGAN BAHAN AJAR ELEKTRONIK SCIENCE FLASHBOOK MATA PELAJARAN IPA KELAS VIII SMP PADA MATERI POKOK PARTIKEL
Authors: Ayubi Syam Alim Al , Danial Muhammad , Sudding . 
Published: May 2019

ABSTRAKPenelitian ini bertujuan mengembangkan dan menghasilkan bahan ajar elektronik Science Flashbook mata pelajaran IPA. Penelitian pengembangan ini menggunakan model pengembangan Plomp yang terdiri dari lima fase yaitu fase investigasi awal, fase desain, fase realisasi/konstruksi, fase tes, evaluasi dan revisi, dan fase implementasi. Subjek uji coba produk pengembangan ini adalah siswa kelas VIII SMPIT Al Biruni Makassar dengan jumlah peserta didik 20 orang. Dalam penelitian ini, teknik pengumpulan data untuk mengukur kevalidan, kepraktisan dan keefektifan yang digunakan adalah angket respon, lembar validasi, lembar pengamatan, dan lembar tes belajar. Teknik analisis data yang digunakan yaitu analisis statistik deskriptif. Hasil penelitian menunjukkan semua item dan aspek yang diukur yaitu penilaian kevalidan media memperoleh kriteria valid dengan nilai rata-rata 3,83, penilaian kepraktisan media adalah praktis dengan persentase 93,75% pada total kriteria “Sangat Setuju” dan “Setuju”. Hasil belajar peserta didik adalah 80% dan 8 aktivitas yang diamati terlaksana dengan baik. Hasil tersebut menujukkan bahwa bahan ajar elektronik Science Flashbook mata pelajaran yang dikembangkan memiliki kategori valid, praktis dan efektif, sehingga dapat disimpulkan bahan ajar elektronik Science Flashbook mata pelajaran IPA yang dihasilkan layak dijadikan sebagai media dan sumber pembelajaran. Kata kunci : pengembangan, bahan ajar elektronik, IPA, partikel, plomp ABSTRACTThis research is about to develop and product the electronic teaching science book. The development research using development model of Plomp which consist of five phases, they are investigation, design, realization/construction, test, evaluation and revision, and implementation. Subject test for development product is 8th Grade student of Islamic Junior High School Al Biruni Makassar which consist of 20 students. Data were collected by measuring validity, practices, and effectivity using questionnaire, validity sheet, observation sheet, and evaluating sheet. Data were analyzed by using descriptive statistics analysis. The results of the study reveal all of the items and the aspects measured are the assessment of media validity obtained valid criteria with value 3,83, the assessment of media practicality was practical with percentage 93,75 int total of “Very Agree” and “Agree”. The result of student test was 80% and 8 activity that observed were achieved. The result indicates that Science Flashbook conducted was valid, practical, and effective. The conclusion is the development of Science Flashbook as electronic teaching science book is feasible as learning media and learning sources. Keywords: development, electronic learning material, science, particle, plomp.
Prevent Intravenous Therapy (IV) Contamination by Addition of Magnesium Oxide Nanoparticles to Silicone Rubber
Authors: Braihi Auda Jabbar , Ahmed Jaleel Kareem , Jabbar Rami Sattar 
Published: May 2019

Antibacterial material nanocomposites are prepared to manufacture intravenous therapy (IV). These composites prepared by adding Magnesium oxide nano powder (MgO NPs) with a different percent (3, 6, and 9 wt %) to Silicone rubber (SR). The activity of this antibacterial material was inspected against S. aureus and E.coli microorganisms by using Agar Well Diffusion method.
Results showed that the addition of MgO NPs to SiR causes the following enhancement the antibacterial activity against E.coli and S.aureus by 7.1% and 27.1% respectively, increasing tensile strength by 65.5%, increasing the hardness by11.25%, increasing the wear resistance by 84.5%, increasing surface bearing index (Sbi) by 80.5% , increasing in core fluid retention (Sci) by 8.5%, decreasing surface roughness (Sa) by 65%, decreasing core roughness depth (Sk) by 67% and enhancement the wettability by decreases contact angle to minimum value.
Editorial
Authors: Mallén Rivera Carlos 
Published: May 2019

México es el tercer país más biodiverso del planeta, por muchas razones es un país grandioso y en términos de recursos naturales, es sorprendente. Sin embargo, por décadas nuestros recursos forestales y los servicios ambientales fueron subvalorados por el gobierno y la sociedad y, en consecuencia, rezagados en las políticas públicas de muchas administraciones. Un ejemplo lamentable de esto fue la existencia del Programa Nacional de Desmontes, en el siglo pasado.
Esta subvaloración basada en el desconocimiento de nuestros recursos naturales respecto a la indiscutible vinculación que tenemos como humanos de sus servicios, unos tan elementales para la vida como el agua, el oxígeno y la regulación del clima condujo a la disminución de oportunidades productivas y un deterioro vigente de la calidad de vida de los dueños de bosque y selvas.
PARTIAL EDENTULISM;
Authors: Kumar Bharat , Kumar Naresh , Ali Shahid , Ahmed Shabir 
Published: May 2019

Objectives: The objective of this study was to determine the various patterns of partial edentulism of mandibular arch in patients seen. Study Design: Cross sectional study. Setting: Department of Prosthodontics, Dr Ishrat- Ul -Ebad Khan Institute of Oral Health Sciences Karachi. Period: Six months from July 2013 to December 2013. Materials and Methods: Utilizing consecutive sampling technique, 527 patients were included. Partial edentulism pattern was recorded by visual examination using Kennedy’s classification after applying Applegate’s rules. Results: In present study class III partial edentulism was the most dominant pattern with class IV being the least in number in mandibular arch. The class III with one modification only involving posterior area was pr-edominant type. As the age of study participants increased, there was decrease in prevalence of class III pattern and increase in class I, class II and class IV pattern. In present study gender had no significant effect on distribution of various Kennedy’s classification, whereas there was statistically significant association between age and pattern of partial edentulism. Conclusion: The Kennedy’s class III was the most common pattern of partial edentulism irrespective of age and gender.
An Improved Image Compression Technique Using EZW and SPHIT Algorithms
Authors: Kadhim Aqeel K. , Merchany Abo Bakir S. , Babakir Ameen 
Published: May 2019

Uncompressed form of the digital images are needed a very large storage capacity amount, as a consequence requires large communication bandwidth for data transmission over the network. Image compression techniques not only minimize the image storage space but also preserve the quality of image. This paper reveal image compression technique which uses distinct image coding scheme based on wavelet transform that combined effective types of compression algorithms for further compression. EZW and SPIHT algorithms are types of significant compression techniques that obtainable for lossy image compression algorithms. The EZW coding is a worthwhile and simple efficient algorithm. SPIHT is an most powerful technique that utilize for image compression depend on the concept of coding set of wavelet coefficients as zero trees. The proposed compression algorithm that combined dual image compression techniques (DICT) invest an excellent features from each methods, which then produce promising technique for still image compression through minimize bits number that required to represent the input image, to the degree allowed without significant impact on quality of reconstructed image.
The experimental results present that DICT will improve the image compression efficiency between 8 to 24%, and will result high performance of metrics values.
ANALISIS STRATEGI E-PROMOTION JASA MAKE-UP ARTIST MELALUI INSTGRAM (Studi Pada Chels Makeup artist di Bandar Lampung)
Authors: Damayanti Damayanti , Ali Suprihatin , Destaia Mediya 
Published: May 2019

This study aims to analyze the e-promotion strategy carried out by chels.makeupartist through instragam. . The research method that used is qualitative research with content analysis approach model and the main data source in this study is Instagram. The findings in this study are the promotional strategies conducted by chels.makeupartist are social media strategies, especially Instagram. In this social media strategy it contains advertising, publicity and sales promotions for either the services or goods offered. The promotion is done by displaying the portfolio of services that have been done on the Instagram account they have.