bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Stretchable and Compressible Self‐Healing P(AA‐co‐AAm)/CoCl2 Hydrogel Electrolyte for Flexible Supercapacitors
Authors: Dai Li‐xin , Zhang Wei , Sun Lu , Wang Xing‐huo , Jiang Wei , Zhu Ze‐wen , Zhang Heng‐bin , Yang Chun‐cai , Tang Jun 
Published: October 2018

AbstractWe report a novel tough self‐healing electrolyte on the basis of poly (acrylic acid‐co‐acrylamide) cross‐linked by divalent cobalt ions (Co2+) (P(AA‐co‐AAm)/CoCl2). Intermolecular and intramolecular hydrogen bonding work together with the metal‐coordination between Co2+ and carboxylic ions to form a hydrogel, which can resist various deformations. The hydrogel electrolyte exhibits excellent mechanical performance (elongation at break >1200 %, compressive stress >600 kPa and compressibility >90 %). The established supercapacitor based on P(AA‐co‐AAm)/CoCl2 can hold its capacitance even after bending, twisting, compressing and self‐healing. Moreover, it retains 90 % capacitance after 5000 cycles. Our electrolyte shows great prospects in manufacture of intelligent flexible equipment.
Elucidation of the Structural Origins and Contrasting Guest–Host Interactions in CO2‐Loaded CdSDB and PbSDB Metal–Organic Frameworks at High Pressures
Authors: Jiang Shan , Hu Yue , Chen Shoushun , Huang Yining , Song Yang 
Published: October 2018

AbstractPbSDB and CdSDB (SDB=4,4′‐sulfonyldibenzoate) are two structurally related SDB‐based metal–organic frameworks (MOFs) that demonstrate promising potential for selective CO2 adsorption capabilities. The structural stabilities and guest–host interactions between CO2 and PbSDB or CdSDB frameworks at high pressures up to 13 GPa in situ were comparatively investigated by Raman spectroscopy, FTIR spectroscopy, and synchrotron X‐ray diffraction. Although both empty frameworks exhibited high chemical stabilities upon compression, they show different pressure‐induced modifications in crystallinity. This difference can be attributed to their different coordination topologies that result in near isotropic contraction of unit cells for the CdSDB framework but anisotropic for the PbSDB framework. Furthermore, the CO2‐loaded PbSDB and CdSDB frameworks at high pressures show strongly contrasting guest–host interactions in terms of the pressure‐regulated CO2 adsorption sites. In both frameworks, pressure can highly efficiently promote the formation of new CO2 adsorption sites and the enhancement of guest–host interactions. In the CO2‐loaded PbSDB framework, in particular, the peculiar pressure‐tuned CO2 population was observed preferentially on one of the two adsorption sites in response to external compression. These unique guest–host interaction behaviors can also be unambiguously correlated to their different topological origins. These findings for the PbSDB and CdSDB frameworks provide in‐depth understanding of the structure–property relationship, which is of fundamental importance for CO2 storage application in SDB‐based MOFs.
Chiral separation and modeling of quinolones on teicoplanin macrocyclic glycopeptide antibiotics CSP
Authors: Ali Imran , Suhail Mohd , Asnin Leonid 
Published: October 2018

AbstractNew chiral high‐performance liquid chromatography (HPLC) method for the enantiomeric resolution of quinolones is developed and described. The column used was Chirobiotic T (150 × 4.6 mm, 5.0 μm). Three mobile phases used were MeOH:ACN:Water:TEA (70:10:20:0.1%), (60:30:10:0.1%), and (50:30:20:0.1%). The flow rate of the mobile phases was 1.0 mL/min with UV detection at different wavelengths. The values of retention, resolution, and separation factors ranged from 1.5 to 6.0, 1.80 to 2.25, and 2.86 to 6.0, respectively. The limit of detection and quantification ranged from 4.0 to 12 ng and 40 to 52 ng, respectively. The modeling studies indicated strong interactions of R‐enantiomers with teicoplanin chiral selector than S‐enantiomers. The supra molecular mechanism of the chiral recognition was established by modeling and chromatographic studies. It was observed that hydrogen bondings and π‐π interactions are the major forces for chiral separation. The present chiral HPLC method may be used for enantiomeric resolution of quinolones in any matrices.
Relationship between high‐sensitivity C‐reactive protein and subclinical carotid atherosclerosis stratified by glucose metabolic status in Chinese adults
Authors: Su Haiyan , Pei Yinghua , Tian Chunling , Zhang Qing , Liu Li , Meng Ge , Yao Zhanxin , Wu Hongmei , Xia Yang , Bao Xue , Gu Yeqing , Sun Shaomei , Wang Xing , Zhou Ming , Jia Qiyu , Song Kun , Sun Zhong , Niu Kaijun 
Published: October 2018

BackgroundAtherosclerosis is an inflammatory disease. Many studies demonstrated that hyperglycemia is not only increased inflammatory response, but also is a cause of atherosclerosis, implying that glucose metabolic status may be an important stratification factor when analyzing the relationship between inflammatory levels and subclinical carotid atherosclerosis. The aim of the present study is to assess the relationship between inflammatory levels and subclinical carotid atherosclerosis, stratified by different glucose metabolic status in a general population.MethodsAn assessment was performed in 7975 participants living in Tianjin, China. In the present study, we examined subclinical carotid atherosclerosis, as defined by increased carotid intima‐media thickness [IMT] and plaques. Measurements were performed using a carotid artery B‐mode ultrasound system. The glucose metabolic status was defined by the criteria of the American Diabetes Association, and high‐sensitivity C‐reactive protein (hs‐CRP) as an inflammatory indicator, was measured by immunoturbidimetric assay. Multiple logistic models were used to assess a stratified relationship between hs‐CRP levels and subclinical carotid atherosclerosis. Strata were defined according to glucose metabolic status.ResultsThe prevalence of increased IMT and plaques were 27.3% and 21.3%, respectively. The adjusted odds ratios (95% confidence interval) for IMT across hs‐CRP quartiles were as follows: 1.00 (reference), 1.10(0.88‐1.38), 1.08(0.86‐1.35) and 1.32(1.06‐1.66) in blood glucose‐normal subjects; 1.00 (reference), 1.33(0.92‐1.91), 1.33(0.93‐1.91), and 1.59(1.10‐2.30) in prediabetic subjects; 1.00 (reference), 0.94(0.54‐1.62), 1.17(0.65‐2.12) and 0.98(0.55‐1.76) in diabetic subjects, respectively. Similar results were observed for plaques.ConclusionsOur results suggest that inflammatory levels are differently related to subclinical carotid atherosclerosis by the different glucose metabolic status.
Influence of unplanned excisions on the outcomes of patients with stage III extremity soft‐tissue sarcoma
Authors: Traub Frank , Griffin Anthony M. , Wunder Jay S. , Ferguson Peter C. 
Published: October 2018

BACKGROUNDSoft‐tissue sarcomas (STSs) are a heterogeneous group of malignant tumors that can be difficult to treat. This is particularly true after incomplete or unplanned excisions and especially for patients with American Joint Committee on Cancer stage III tumors, who are at high risk for relapse. Numerous studies have shown that an inadequate sarcoma excision is associated with a worse prognosis. However, other reports have suggested an improved prognosis for patients with an initial unplanned excision and subsequent re‐excision in comparison with patients who undergo planned primary surgery. The purpose of this study was to determine the impact of an unplanned excision on treatment and subsequent oncologic and functional outcomes for patients with stage III extremity STS.METHODSFrom the prospectively collected database at a tertiary‐referral sarcoma center, all patients with stage III STS of the extremities treated between 1989 and 2010 were identified. Patient records were reviewed to identify patient demographics, tumor details, treatments, complications, and functional and oncologic outcomes.RESULTSFive hundred patients with stage III STSs of the extremities were identified, and 94 of these patients (18.8%) were referred after inadequate excisions had been performed elsewhere. All 94 patients with unplanned excisions underwent re‐excision in an attempt to achieve clear margins, and 83% of these patients had residual tumor in the re‐excision specimen. In the re‐excision group, the rates of plastic reconstruction (eg, skin grafts and rotational or free flaps) and amputation were significantly higher in comparison with the rates for patients who underwent a primary planned resection (P = .023 and P = .03, respectively). The rates of local recurrence, metastasis‐free survival, and overall survival were not significantly different between the 2 groups, nor were the functional outcomes.CONCLUSIONSUnplanned excision of stage III STS leads to an unfavorable clinical course and necessitates more extensive surgery. As a result of aggressive re‐excision and multidisciplinary treatment, a negative effect on oncologic outcomes cannot be confirmed.
Sentiment classification of micro‐blog comments based on Randomforest algorithm
Authors: Liu Xiao‐Qin , Wu Qiu‐Lin , Pan Wen‐Tsao 
Published: October 2018

SummarySentiment classification of Micro‐blog comments aims to distinguish consumers' attitudes toward a certain brand or an event. A great number of research studies related to sentiment analysis have been conducted based on machine learning methods, such as Support Vector Machine and Naive Bayes, to build the classifier, and some other research studies tried to build one based on emotional thesaurus. However, the rate of accuracy is yet to improve. In order to improve the accuracy rate further, this thesis bases on the Randomforest algorithm to construct an emotional tendency classifier to help the mobile phone service providers to further understand consumers' attitudes toward their brand. The Randomforest algorithm is a bagging algorithm of the ensemble learning with some weak classifiers, which works very well in anti‐noise and reducing the overfitting problem. Finally, a classifier with an 83% accuracy rate for sentiment classification of mobile phone brands on Micro‐blog comments was built based on Randomforest by using R language software.
Study on the posts and performance evaluation model of inpatients in public hospitals based on .NET platform DRGs payment mode
Authors: Lin Xia , Huang Qingjia , Bai Fei , Jin Dun , Lu Wei , Tao Hongbing 
Published: October 2018

SummaryPerformance appraisal is a daily, homework, fair, and open appraisal of each hospital, which can mobilize the enthusiasm and creativity of the employees to the greatest extent so that both the company and the employees can achieve development. At present, the ascendant information revolution has become an important factor in promoting the development of the times. The use of advanced information technology to develop advanced information systems to conduct fair and open assessments of the ever‐increasing number of company employees has become the trend of the times. This article makes a historical review of the development and function of the performance appraisal system, and fully analyzes the new features and new functions of the performance appraisal system in the new period, and details the solution. This system develops and uses .NET development platform and SQL Server 2005 database. Using a distributed approach, the system's development costs have reduced, and the system's maintainability and scalability are improved. This paper studies the establishment of a performance‐based distribution model based on diagnostic relevance grouping theory (DRGs) in public hospitals. Based on the DRGs as a theoretical basis, after a long period of historical data collection, a theoretical model was established, repeated regression calculations, and focused evaluations. A performance‐distribution scheme centered on workload has established to reflect the factors such as the labor risk, technical difficulty, and labor cost of the attending doctors in relation to different patient conditions. The formulation and implementation of the new performance plan embodies the input of labor value and conforms to the spirit of the new medical reform.
Research on the clustering algorithm of the bicycle stations based on OPTICS
Authors: Liu Liangxu , Hu Zhenghua , Zhou Chaolan , Xu Guohu 
Published: October 2018

SummaryWith the development of the sharing traffic economy, the urban fixed‐station parking public bicycle system greatly facilitates the residents to travel. However, the tidal problem has greatly reduced the social utility of the public bicycle system. A step‐by‐step scheduling strategy has been put forward to solve the problem, which firstly clusters the stations according to station locations or the number of bicycles circulating in a station and then perform regional scheduling in each cluster. However, because the clusters obtained by this method do not have the characteristics of a closed small‐world network, the strategy does not cover all stations that require bicycle scheduling. To fix the gap, a station clustering algorithm is proposed, which employs SimRank to calculate the similarity between the stations according to the loan‐to‐return relationship and then adopts the density clustering algorithm of OPTICS (ordering points to identify the clustering structure) to cluster all stations based on the similarity. The data of public bicycle system in Ningbo City, Zhejiang Province of China, is employed to validate the algorithm. The experiment found that the station clustering results have distinct regional characteristics, and the algorithm is competent to divide the scheduling area of public bicycles.
Fluorination‐Induced Evolution of Columnar Packing in Fluorous Triphenylenes and Benzotriphenylenes
Authors: Rippy Kerry C. , DeWeerd Nicholas J. , Kuvychko Igor V. , Chen Yu‐Sheng , Strauss Steven H. , Boltalina Olga V. 
Published: October 2018

AbstractUse of D3h‐symmetrical triphenylene (TRPH) as a substrate for high‐temperature radical reactions with C4F8I2 under varying conditions resulted in the introduction of four types of fluorinated substituents: ω‐C4F8H, c‐C4F8, c‐C4F4, and c‐C4HF3. In contrast to the previous work on direct (poly)substitutions with RF groups in polycyclic aromatic hydrocarbons (PAHs), in this work regiospecificity, selectivity, and high yield were achieved for TRPH(C4F8) and TRPH(C4F8)3. New single‐crystal structural data for seven compounds combined with literature crystallographic data allowed for the first detailed and precise analysis of the effects of fluorous substituent types, their number, and their position(s) on the TRPH core on the solid‐state packing, and more specifically, the degree of π–π overlap between neighboring molecules, which is linked to charge transport properties. Comparison of isostructural partially fluorinated benzotriphenylenes, 2,3‐TRPH(C4F4) and 2,3‐TRPH(C4HF3), revealed an unexpectedly large (30 %) drop of π–π overlap, when only one fluorine atom was replaced with the hydrogen atom in a C4F4 moiety. Theoretical and potentially practical implications of this work may include further testing and elaboration of computational methods describing solid‐state interactions and predictions of transport properties of organic semiconductors, and further advances in the molecular design of high‐performing TRPH‐based organic materials and supramolecular architectures for organic optoelectronics.
Site‐Selective Cu‐Catalyzed Alkylation of α‐Amino Acids and Peptides toward the Assembly of Quaternary Centers
Authors: San Segundo Marcos , Correa Arkaitz 
Published: October 2018

AbstractThe CuI‐catalyzed selective α‐alkylation of α‐amino acid and peptide derivatives with 2‐alkyl‐1,3‐dioxolanes is reported. This oxidative coupling is distinguished by its site‐specificity, high diastereoselectivity, and chirality preservation and exhibits absolute chemoselectivity for N‐aryl glycine motifs over other amino acid units. Collectively, the method allows for the assembly of challenging quaternary centers, as well as compounds derived from natural products of high structural complexity, which may provide ample opportunities for late‐stage functionalization of peptides.
Network service chains deployment across multiple SDN domains
Authors: Zhang Chuangchuang , Wang Xingwei , Li Fuliang , Huang Min , He Qiang 
Published: October 2018

SummaryThe integration of software‐defined networking (SDN) and network function virtualization (NFV) enables the flexible deployment of network services and significant reduction in service provisioning cost. In particular, SDN, as a new networking paradigm, supports the flexible provisioning of new network services. Meanwhile, in NFV, the service request from end user can be represented as the service function chain (SFC). However, with the continuously increasing of network users and constant enlargement in network scale, the deployment of network services in the large‐scale SDN network, which is composed of multiple SDN domains, becomes more challenging since these SDN domains are managed and maintained by different network operators and service providers. To address the above challenge, in this paper, we study the problem of how to deploy network services across multiple SDN domains optimally. Specifically, we first formulate this problem as an optimization problem by jointly minimizing the total number of SDN domains occupied by SFCs and the corresponding network resource consumption cost. We propose a novel heuristic deployment algorithm to solve this optimization problem. The simulation results demonstrate that the proposed heuristic deployment algorithm is effective and outperforms the comparison algorithms in terms of the total service cost.
During acute graft versus host disease CD28 deletion in donor CD8+, but not CD4+, T cells maintain antileukemia responses in mice
Authors: Uri Anna , Lühder Fred , Kerkau Thomas , Beyersdorf Niklas 
Published: October 2018

AbstractDonor lymphocyte infusions together with allogeneic hematopoietic stem cell transplantation are routinely used as second‐line treatment for hematological malignancies. Mature T cells in the graft crucially mediate a graft versus leukemia (GvL) response, but also attack healthy tissues in the recipient leading to potentially life‐threatening acute graft versus host disease. Using inducible CD28 knockout C57BL/6 mice as T‐cell donors, we have now assessed whether CD28 costimulation of donor CD4+ and/ or CD8+ T cells is required for an efficient GvL effect after allogeneic T‐cell transplantation into BALB/c recipients. Our results show that CD28 costimulation of donor CD8+ cytotoxic, but not CD4+ helper, T cells was dispensable for curing mice from the BCL‐1 lymphoma. Therefore, donor lymphocyte infusion treated lymphoma‐bearing BALB/c recipient mice showed enhanced long‐term survival when receiving CD28‐deficient as compared to wild‐type donor CD8+ T cells together with wild‐type conventional and regulatory CD4+ T cells. The same was observed when donor CD8+ and conventional and regulatory CD4+ T cells were CD28 deficient. Our data, thus, suggest that systemic CD28 blockade, for example, with the drug FR104 might also reduce acute graft versus host disease in patients after allogeneic hematopoietic stem cell transplantation, while maintaining the protective GvL response.
Trajectories of posttraumatic stress symptoms after whiplash: A prospective cohort study
Authors: Ravn Sophie L. , Karstoft Karen‐Inge , Sterling Michele , Andersen Tonny E. 
Published: October 2018

AbstractBackgroundPosttraumatic stress disorder (PTSD) symptoms are highly prevalent after whiplash and associated with pain‐related symptoms. While mutual maintenance between pain and PTSD has been suggested, knowledge on individual differences in the course of these symptoms is needed. The present study aimed to identify trajectories of PTSD symptoms following whiplash and test predictors and functional outcomes of such trajectories.MethodsIn a prospective cohort design with assessments at baseline (<4 weeks), 3 months, and 6 months post‐injury (n = 229, whiplash grade I‐III), we identified PTSD‐trajectories using Latent Growth Mixture Modeling. Predictors (pain, fear‐avoidance‐beliefs, pain‐catastrophizing, depression, age, and gender) were tested using multinomial logistic regression, and group mean differences in physical and psychosocial pain‐related disability at 6 months were tested as outcomes after controlling for baseline levels.ResultsThree trajectories were identified: “Resilient” (75.1%) with little or no PTSD symptoms over time, “Recovering” (10.0%) with high initial PTSD symptom levels, then decreasing substantially, and “Chronic” (14.9%) with high initial PTSD symptom levels and a small increase over time. Initial higher pain and depression levels predicted the recovering and chronic trajectories, while the latter had more pain‐related disability at 6 months compared to both other trajectories.ConclusionsThree trajectories were identified, with the chronic trajectory suggesting that a significant subset of people does not recover from PTSD symptoms. This class also reported more pain‐related disability. Pain and depression predicted membership, but did, however, not succeed in differentiating between the two high‐starting trajectories, suggesting that targeting PTSD symptoms may be important to ensure recovery.SignificanceDistinct recovery patterns after whiplash were identified with a significant subgroup reporting elevated and slightly increasing PTSD symptoms over time, highlighting both recovery variability and the presence of PTSD symptoms in a significant subgroup of individuals with whiplash. This subgroup also displayed enhanced pain‐related disability over time compared to the recovering and resilient subgroups, thereby linking PTSD symptoms to functional pain outcomes over time. These findings suggest that clinicians should be attentive of potential PTSD symptoms in whiplash patients.
Electrochemical Study on Quantitative Structure‐activity Relationship (QSAR) Analysis under Steady‐state Conditions
Authors: Takaishi M. , Shirai O. , Kitazumi Y. , Kano K. 
Published: October 2018

AbstractThe influence of the volume ratio of the aqueous to 1‐octanol phase on drug delivery under steady‐state conditions in a tubular electrolytic cell composed of an organic phase and two aqueous phases was elucidated. Electrochemical measurements on the transport of six quaternary ammonium chlorides were performed using three types of membrane filters of different thickness. The electric resistance of each system was evaluated, and the distribution coefficient of each chloride was estimated from the extraction experiments. The permeation process within the organic phase was the rate‐determining step for tetrapropylammonium, tetrabutylammonium, tetrapentylammonium and tetrahexylammonium chlorides. On the other hand, for tetraoctylammonium chloride, which was the most hydrophobic ion among the six tested, the salt was easily distributed into the organic phase. Therefore, the rate‐determining step changed to the permeation process within the aqueous phase. In addition, the influence of ion‐pair formation on drug delivery was evaluated.