bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural correlates of dynamic changes in working memory performance during one night of sleep deprivation
Authors: Zhu Yuanqiang , Xi Yibin , Sun Jinbo , Guo Fan , Xu Yongqiang , Fei Ningbo , Zhang Xinxin , Yang Xuejuan , Yin Hong , Qin Wei 
Published: April 2019

AbstractTotal sleep deprivation (TSD) is common in modern society leading to deterioration of multiple aspects of cognition. Dynamic interaction effect of circadian rhythmicity and homeostatic sleep pressure on sustained attention have been intensively investigated, while how this effect was represented on performance and cerebral responses to working memory, another important element of many neurobehavioral tasks, was not well elucidated. Thirty‐six healthy subjects with intermediate chronotype performed the Sternberg working‐memory task (SWMT) while undergoing functional magnetic resonance imaging every 2 hr from 10:00 p.m. on the first day to 6:00 a.m. on the second day. Using data from three imaging sessions (10:00 p.m., 04:00 a.m., and 06:00 a.m.), we found that the slowest SWMT reaction time and weakest cerebral responses were not at the end of TSD (06:00 a.m.) but during the early morning (04:00 a.m.) hours of the TSD. In addition, during this worst period of TSD, reaction time for the SWMT were found to be negatively correlated with task‐related activation in the angular gyrus and positively correlated with the degree of negative correlation between the control and default networks. Our results revealed a rebound of SWMT reaction time and cerebral responses after the mid‐time point of regular biological sleep night and provided more evidence that different cognitive tasks are differentially affected by sleep loss and circadian rhythmicity.
Altered expression patterns of complement factor H and miR‐146a genes in acute‐chronic phases in experimental autoimmune encephalomyelitis mouse
Authors: Gharibi Saba , Moghimi Bahram , Haghmorad Dariush , Mahmoudi Mohammad Bagher , Shahvazian Ensieh , Yadegari Maryam , Yazd Ehsan Farashahi , Tahoori Mohammad Taher 
Published: April 2019

AbstractConsiderable advances have been made in identification of the involvement of immune modulators in diseases. There is growing evidence on the role of complement pathway in pathogenesis and course of multiple sclerosis (MS). Moreover, it has been recognized that microRNAs (miRNAs) play an essential role in modulation and development of immune response in the central nervous system. We aimed to investigate the expression profile of complement factor H (CFH) and miR‐146a genes in experimental autoimmune encephalomyelitis (EAE) mouse model of MS to detect the possible roles of CFH and miR‐146a as biomarkers of MS disease stats. Expression of CFH and miR‐146a genes in liver and brain tissues of EAE mice was measured in acute and chronic phases of disease compared to matched controls using real‐time polymerase chain reaction. In the liver, increased expression of CFH gene was observed in the chronic phase compared to the acute phase. However, no significant difference was observed between acute and chronic phase mice with normal mice, while miR‐146a expression was significantly decreased in livers of EAE mice in chronic group compared to acute and control groups. The expression of CFH gene in brain had a significant decrease in acute and chronic phases compared to healthy mice. Taken together, these observations indicate probable implication of complement system and miR‐146a in course of immune‐related diseases and reveal more facts about the pathogenesis of MS. However, further work is needed to determine protein levels of CFH and other possible targets of miR‐146a in serum and cerebrospinal fluid of MS patients.
Ursodeoxycholic acid stimulates alveolar fluid clearance in LPS‐induced pulmonary edema via ALX/cAMP/PI3K pathway
Authors: Niu Fangfang , Xu Xiaotao , Zhang Rong , Sun Lingling , Gan Ning , Wang Aizhong 
Published: April 2019

AbstractThis study aims to examine the impact of ursodeoxycholic acid (UDCA) on pulmonary edema and explore the underlying molecular mechanisms. The effects of UDCA on pulmonary edema were assessed through hematoxylin and eosin (H&E) staining, lung dry/wet (W/D) ratio, TNF‐α/IL‐1β levels of bronchoalveolar lavage fluid (BALF), protein expression of epithelial sodium channel (ENaC), and Na+/K+‐ATPase. Besides, the detailed mechanisms were explored in primary rat alveolar type (AT) II epithelial cells by determining the effects of BOC‐2 (ALX [lipoxin A4 receptor] inhibitor), Rp‐cAMP (cAMP inhibitor), LY294002 (PI3K inhibitor), and H89 (PKA inhibitor) on the therapeutic effects of UDCA against lipopolysaccharide (LPS)‐induced changes. Histological examination suggested that LPS‐induced lung injury was obviously attenuated by UDCA. BALF TNF‐α/IL‐1β levels and lung W/D ratios were decreased by UDCA in LPS model rats. UDCA stimulated alveolar fluid clearance (AFC) though the upregulation of ENaC and Na+/K+‐ATPase. BOC‐2, Rp‐cAMP, and LY294002 largely suppressed the therapeutic effects of UDCA. Significant attenuation of pulmonary edema and lung inflammation was revealed in LPS‐challenged rats after the UDCA treatment. The therapeutic efficacy of UDCA against LPS was mainly achieved through the ALX/cAMP/PI3K pathway. Our results suggested that UDCA might be a potential drug for the treatment of pulmonary edema induced by LPS.
CCDN1 rs603965 polymorphism may serve as a genetic biomarker of brain tumor: A meta‐analysis of 5,769 subjects
Authors: Lan Jiarong , Li Min , Wang Haifeng 
Published: April 2019

AbstractIntroductionSome studies already tried to assess the associations between cyclin D1 (CCND1) polymorphisms and brain tumor. However, the results of these studies were not consistent. Thus, we performed the present meta‐analysis to explore the relationship between CCND1 polymorphisms and brain tumor in a larger pooled population.MethodsPubMed, Web of Science, Embase, and CNKI were searched for related articles. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the potential associations.ResultsTotally nine studies with 5,769 subjects were analyzed. A significant association with brain tumor susceptibility was observed for the rs603965 polymorphism in GG versus GA + AA (dominant comparison, p = 0.003, OR = 0.72, 95% CI 0.57–0.89, I2 = 64%), AA versus GG + GA (recessive comparison, p = 0.004, OR = 1.46, 95% CI 1.13–1.88, I2 = 67%), and G versus A (allele comparison, p = 0.0004, OR = 0.77, 95% CI 0.66–0.89, I2 = 66%) in overall population. Further subgroup analyses by ethnicity yielded similar positive results in both Asians and Caucasians. Moreover, in stratified analyses by type of disease, we noticed that the rs603965 polymorphism was significantly associated with the susceptibility to glioma, but such positive results were not detected in pituitary adenoma or meningioma. Additionally, a significant association with tumor grade was also observed for the rs603965 polymorphism in G versus A (allele comparison, p = 0.02, OR = 0.74, 95% CI 0.59–0.95, I2 = 26%).ConclusionsOur findings suggested that CCND1 rs603965 polymorphism may serve as a potential genetic biomarker of brain tumor, especially for glioma.
Whole‐Body Muscle Magnetic Resonance Imaging in Glycogen‐Storage Disease Type III
Authors: Tobaly David , Laforêt Pascal , Perry Ariane , Habes Dalila , Labrune Philippe , Decostre Valerie , Masingue Marion , Petit Francois , Barp Andrea , Bello Luca , Carlier Pierre , Carlier Robert‐Yves 
Published: April 2019

ABSTRACTIntroduction: The main objective of this study was to describe muscle involvement on whole‐body magnetic resonance imaging scans in adults at different stages of glycogen‐storage disease type III (GSDIII). Methods: Fifteen patients, 16–59 years of age, were examined on a 3‐T system. The examinations consisted of coronal and axial T1‐weighted images or fat images with a Dixon technique, and were scored for 47 muscles using Mercuri's classification. Muscle changes consisted of internal bright signals of fatty replacement. Results: Distribution across muscles showed predominant signal alteration in the lower limbs and postural muscles. This finding is consistent with the overall clinical presentation of GSDIII and the results of heatmap scores. Review of the MRI scans provided new information regarding recurrent muscle changes, particularly in the soleus, gastrocnemius medial head, and thoracic extensor muscles. Discussion: Whole‐body muscle imaging provides clinically relevant information regarding muscle involvement in GSDIII. A severity score may contribute to improved patient management. Muscle Nerve, 2019
A binary‐regularization‐based model predictive control applied to generation scheduling in concentrating solar power plants
Authors: Cojocaru Emilian G. , Bravo José M. , Vasallo Manuel J. , Marín Diego 
Published: April 2019

SummaryThis paper proposes the use of model predictive control (MPC) with binary‐regularization to manage the electric power generation problem in concentrating solar power plants with thermal energy storage. The main advantage of the of MPC with binary‐regularization formulation is the inclusion of a power block protection method based on a binary‐regularization term that penalizes power generation variation (also called generation cycling) differently according to the power block situation, ie, normal operation, startup, or shutdown. This distinction simplifies the choice of schedules with reduced variation and high energy sale profits. The interest in this reduction is the achievement of a higher lifetime of the power block elements, lower maintenance costs, and easier plant operability. A benefit of the generation scheduling based on MPC is the capacity of rescheduling the power generation at regular periods, taking advantage of the most recent energy prices and weather forecast, and of the plant's current state. An interesting question is if the proposed protection mechanism affects the economic results of the MPC black strategy. In this regard, an economic study based on a realistic simulation of a 50 MW parabolic trough collector‐based concentrating solar power plant with thermal energy storage, under the assumption of participation in the Spanish day‐ahead energy market scenario, is included. Realistic values for actual and forecasted solar resource and for energy price are used, and for penalties for deviation from the committed generation schedule. The economic study shows that the proposed scheduling method provides an important reduction of the generation cycling without decreasing energy sales profits. Another advantage of the proposed method is the possibility of estimating the highest level of power block protection, which maintains the profits by means of historical data, which favors its practical implementation.
The impact of childhood cancer on parents' socio‐economic situation—A systematic review
Authors: Roser Katharina , Erdmann Friederike , Michel Gisela , Winther Jeanette Falck , Mader Luzius 
Published: April 2019

AbstractObjectiveTaking care of children diagnosed with cancer may have considerable consequences on parents' socio‐economic situation. Our systematic review aimed to evaluate and synthesise the evidence on the impact of childhood cancer on parents' socio‐economic situation.MethodsSystematic literature searches for articles published between January 2000 and January 2019 were performed in PubMed, Scopus, and PsycINFO. Findings of eligible articles were narratively synthesised and quality appraised.ResultsOur systematic review included 35 eligible articles. Childhood cancer had a substantial impact on parents' socio‐economic situation across all studies. This impact varied largely by geographical region. We observed a high prevalence of disruptions in parental employment such as job quitting or job loss, particularly among mothers. The associated income losses further contributed to families' perceived financial burden in addition to increased cancer‐related expenses. Adverse socio‐economic consequences were most pronounced shortly after diagnosis, however, persisted into early survivorship for certain groups of parents. We identified families of children diagnosed with haematological cancers, younger age at diagnosis, and lower parental socio‐economic position to be at particular risk for adverse socio‐economic consequences.ConclusionsFollowing the child's cancer diagnosis, parents experience a broad range of adverse socio‐economic consequences. Further effort is needed to systematically implement an assessment of financial hardship in paediatric oncology together with appropriate support services along the cancer trajectory.
A novel adhesive trunk trap net for trapping Eucryptorrhynchus brandti (Coleoptera: Curculionidae)
Authors: Yang Kailang , Wen Xiaojian , Guo Wenjuan , Wen Junbao 
Published: April 2019

AbstractBACKGROUNDEucryptorrhynchus brandti (Harold) is a destructive wood‐boring pest of tree of heaven, Ailanthus altissima, in China. At present, the management of E. brandti relies exclusively on frequent applications of synthetic insecticides. Environmentally friendly alternatives to the use of synthetic insecticides would be beneficial. A trunk trap net (TTN), an adhesive trap (AT), and an adhesive trunk trap net (ATTN) were evaluated in their ability to capture E. brandti.RESULTSSignificantly greater laboratory weevil recapture rates were found using the ATTN (78%) than using the TTN (8%) and AT (0%). In total, 45% of marked weevils were captured by the ATTN, an eight‐fold increase in catch rates using the TTN in mark‐release‐recapture field trials in 2017. No marked weevils were captured by the AT. Field trials in 2017 and 2018 showed that the ATTN captured six to seven times more wild weevils than using the TTN.CONCLUSIONAdhesive Trunk Trap nets (ATTNs) were more effective in capturing E. brandti adults than Trunk Trap nets (TTNs). These results support the use of the ATTN as an eco‐friendly tool for the integrated management of E. brandti. © 2019 Society of Chemical Industry
Non‐target effects of herbicides on Tetranychus urticae and its predator, Phytoseiulus persimilis: implications for biological control
Authors: Schmidt‐Jeffris Rebecca A , Cutulle Matthew A 
Published: April 2019

AbstractBACKGROUNDA key element of conservation biocontrol is identifying and limiting the use of pesticides that have substantial non‐target effects on natural enemies to prevent biocontrol disruption. The Phytoseiidae (predatory mites) are one of the most studied natural enemy groups in the field of pesticide non‐target effects. Although there is substantial research on the non‐target effects of insecticides on arthropod natural enemies, research on herbicide impacts is limited. Natural enemies, including phytoseiids, associate with weeds due to the presence of alternative prey, shelter, or floral resources. Therefore, a whole‐systems approach to integrated pest management should integrate weed management with biocontrol. We conducted a study to examine the non‐target effects of vegetable herbicides on Phytoseiulus persimilis Athias‐Henriot, and the primary pest that it controls, Tetranychus urticae Koch. Two assays were used to assess the effects of direct application and walking on residues.RESULTSIn both assays, S‐metolachlor was highly toxic to P. persimilis (80–90% mortality) and had minimal effect on T. urticae. Dicamba, oxyfluorfen, and napropamide also caused moderate levels of P. persimilis mortality (21–74%). Check mortality of P. persimilis was higher in the direct contact assay (19%) than the residue assay (3%).CONCLUSIONSHalosulfuron‐methyl, flumioxazin, and mesotrione were the most compatible herbicides with biocontrol by P. persimilis, whereas S‐metolachlor and napropamide were the least compatible. We also determined that the residue assay may be more useful than direct contact slide‐dips for future assessment of herbicide non‐target effects. Future efforts should continue to examine the impacts of weed management on natural enemies to better integrate pest management practices. © 2019 Society of Chemical Industry
Half‐space contact problem considering strain gradient and surface effects: An analytical approach
Authors: Moradweysi P. , Ansari R. , Gholami R. , Bazdid‐Vahdati M. , Rouhi H. 
Published: April 2019

AbstractIn this article, an analytical approach is proposed for the problem of an elastic half‐space under symmetrically distributed normal force with arbitrary profile including uniform pressure, Boussinesq flat‐ended punch, conical punch and Hertz's spherical punch. The formulation of the work is on the basis of Mindlin's first strain gradient theory with five material length scale parameters. Also, the surface effects are taken into account using the Gurtin‐Murdoch surface elasticity theory. The developed mathematical formulation is general so that it can be simply reduced to different strain gradient‐based theories such as the modified versions of strain gradient and modified couple stress theories (MSGT and MCST), the simplified strain gradient theory (A‐SGT), as well as the classical theory (CT). In the solution procedure, an analytical method is applied using the Fourier and Hankel transforms. In the numerical results, the effects of material length scale parameters and kind of punch on the surface displacements and stresses of the half‐space are analyzed. The surface influences are also comprehensively studied. Moreover, comparisons are made between the predictions of MSGT, MCST, A‐SGT and CT. This work shows that the material length scale parameters of Mindlin's first SGT play important roles in the response of half‐space. Also, the presented results provide a comparison between the intensity of effects of strain gradient parameters and surface parameters.
The determination of real fluid requirements in laparoscopic resection of pheochromocytoma using minimally invasive hemodynamic monitoring: a prospectively designed trial
Authors: Niederle Martin B. , Fleischmann Edith , Kabon Barbara , Niederle Bruno 
Published: April 2019

AbstractBackgroundHemodynamic instability is frequently observed during adrenalectomy for pheochromocytoma (PCC). Guidelines recommend liberal preoperative volume administration. However, it is unclear whether fluid deficiency or vasoplegia causes shifting hemodynamics and whether minimally invasive hemodynamic monitoring with esophageal Doppler (EDM) can help visualize intraoperative changes avoiding volume overload and complications.MethodsTen patients with biochemically verified PCC and five patients with hormonally inactive adrenal tumors (HIAT; control group) were treated following a strict protocol. During laparoscopic adrenalectomy, goal-directed fluid therapy was performed using EDM. Hemodynamic and biochemical data were documented. The primary outcome variables were fluid requirement and hemodynamic parameters.ResultsApplying EDM, total intraoperative fluid administration was slightly higher in PCC patients than in patients with HIAT (2100 ± 516 vs. 1550 ± 622 ml,p = 0.097; 12.9 ± 4.8 vs. 8.3 ± 0.7 ml kg−1h−1,p = 0.014). Hemodynamics varied considerably within the PCC group and was associated with type and level of secreted catecholamines. Arterial blood pressure and systemic vascular resistance index reached their minimum in the 10-min period after resection of PCC. Without liberal fluid administration, an increase in cardiac index was observed in both groups comparing baseline measurements to end of surgery. This increase was statistically significant only in PCC patients (PCC: 2.31 vs. 3.15 l min−1m−2,p = 0.005; HIAT: 2.08 vs. 2.56 l min−1m−2,p = 0.225).ConclusionsAs vasoplegia, but not hypovolemia, was documented after tumor resection, there is no evidence that PCC patients profit from liberal fluid administration during laparoscopic adrenalectomy. To avoid volume overload, noninvasive techniques such as EDM should be routinely used to visualize the variable intraoperative course.Trial registration: ClinicalTrials.gov, Identifier: NCT01425710.
Urbanisation and nest building in birds: a review of threats and opportunities
Authors: James Reynolds S. , Ibáñez-Álamo Juan D. , Sumasgutner Petra , Mainwaring Mark C. 
Published: April 2019

AbstractThe world is urbanising rapidly, and it is predicted that by 2050, 66% of the global human population will be living in urban areas. Urbanisation is characterised by land-use changes such as increased residential housing, business development and transport infrastructure, resulting in habitat loss and fragmentation. Over the past two decades, interest has grown in how urbanisation influences fundamental aspects of avian biology such as life-history strategies, survival, breeding performance, behaviour and individual health. Here, we review current knowledge on how urbanisation influences the nesting biology of birds, which determines important fitness-associated processes such as nest predation and community assembly. We identify three major research areas: (i) nest sites of birds in urban areas, (ii) the composition of their nests, and (iii) how these aspects of their nesting biology influence their persistence (and therefore conservation efforts) in urban areas. We show that birds inhabiting urban areas nest in a wide variety of locations, some beneficial through exploitation of otherwise relatively empty avian ecological niches, but others detrimental when birds breed in ecological traps. We describe urban-associated changes in nesting materials such as plastic and cigarette butts, and discuss several functional hypotheses that propose the adaptive value and potential costs of this new nesting strategy. Urban areas provide a relatively new habitat in which to conserve birds, and we show that nestboxes and other artificial nest sites can be used successfully to conserve some, but not all, bird species. Finally, we identify those subject areas that warrant further research attention in the hope of advancing our understanding of the nesting biology of birds in urban areas.
Long-term efficacy and safety of tenofovir disoproxil fumarate in Chinese patients with chronic hepatitis B: 5-year results
Authors: Liang Xieer , Gao Zhiliang , Xie Qing , Zhang Jiming , Sheng Jifang , Cheng Jun , Chen Chengwei , Mao Qing , Zhao Wei , Ren Hong , Tan Deming , Niu Junqi , Chen Shijun , Pan Chen , Tang Hong , Wang Hao , Mao Yimin , Jia Jidong , Ning Qin , Xu Min , Wu Shanming , Li Jun , Zhang Xinxin , Zhang Wenyan , Xiong Cui , Hou Jinlin 
Published: April 2019

Abstract
Background and aim
Long-term treatment with tenofovir disoproxil fumarate (TDF) has demonstrated suppression of viral replication outside of China. This study aims to assess efficacy, resistance and safety of TDF for up to 240 weeks in Chinese patients with chronic hepatitis B virus (HBV) infection.

Methods
Patients (HBeAg-positive or HBeAg-negative) who were randomised to receive TDF 300 mg or adefovir dipivoxil (ADV) 10 mg once daily in the 48-week double-blind phase (N = 498) were eligible to enter the open-label TDF phase (TDF–TDF and ADV–TDF groups) for additional 192 weeks.

Results
Overall, 457/512 (89.3%) randomised patients completed 240 weeks of treatment. Virological suppression was achieved in 84.5% and 87.9% in HBeAg-positive patients and 89.6% and 89.5% in HBeAg-negative patients in TDF–TDF and ADV–TDF groups, respectively, at week 240. The majority of patients from both groups had normalized alanine transaminase levels. More patients had HBeAg loss (41.7% vs. 36.4%) and HBeAg seroconversion (32.0% vs. 28.3%) in TDF–TDF than in ADV–TDF group, respectively. Only one HBeAg-positive patient in TDF–TDF group had HBsAg loss at week 240. No evidence of resistance to TDF was observed. The incidence of adverse events was similar in both groups (TDF–TDF, 56.4% vs. ADV–TDF, 51.6%). One patient had serum creatinine elevation ≥ 0.5 mg/dL above baseline, and three patients had confirmed grade 3/4 phosphorus abnormalities (< 2 mg/dL).

Conclusion
In Chinese patients with chronic HBV, long-term treatment with TDF showed sustained viral suppression without development of resistance up to 240 weeks. No new safety concerns were found with TDF in this patient population.
Clinical Trial Registration ClinicalTrial.gov Identifier NCT01300234; GSK Clinical Study Register 114648.