bluuebunny/crossref_metadata_2025_split huggingface dataset:
Classification of aggressive and classic mantle cell lymphomas using synchrotron Fourier Transform Infrared microspectroscopy
Authors: Kolodziej Magdalena , Jesionek-Kupnicka Dorota , Braun Marcin , Atamaniuk Vitaliy , Sloniec Sylwia , Cebulski Jozef , Cholewa Marian , Kopczynski Janusz , Heraud Philip , Tobin Mark J. , Vongsvivut Jitraporn , Zawlik Izabela 
Published: September 2019

AbstractMantle cell lymphoma (MCL) is regarded as an incurable neoplasm, even to the novel drug strategies. It is known MCL has two morphological variants- classic and aggressive. Aggressive MCL is characterized by a higher mitotic index and proliferation rate, and poor overall survival in comparison to classic subtype. The insight into the detailed biochemical composition of MCL is crucial in the further development of diagnostic and treatment guidelines for MCL patients; therefore Synchrotron radiation Fourier Transform Infrared (S-FTIR) microspectroscopy combined with Principal Component Analysis (PCA) was used. The major spectral differences were observed in proteins and nucleic acids content, revealing a classification scheme of classic and aggressive MCLs. The results obtained suggest that FTIR microspectroscopy has reflected the histopathological discrimination of both MCL subtypes.
Development and Validation of a Risk Scoring System for Cephamycin-Associated Hemorrhagic Events
Authors: Chien Tong-Ling , Hsiao Fei-Yuan , Chen Li-Ju , Wen Yu-Wen , Lin Shu-Wen 
Published: September 2019

AbstractCephamycin-associated hemorrhages have been reported since their launch. This research aimed to determine risk factors for cephamycin-associated hemorrhagic events and produce a risk scoring system using National Taiwan University Hospital (NTUH) database. Patients who were older than 20 years old and consecutively used study antibiotics for more than 48 hours (epidode) at NTUH between January 1st, 2009 and December 31st, 2015 were included. The population was divided into two cohorts for evaluation of risk factors and validation of the scoring system. Multivariate logistic regression was used for the assessment of the adjusted association between factors and the outcome of interest. Results of the multivariate logistic regression were treated as the foundation to develop the risk scoring system. There were 46402 and 22681 episodes identified in 2009–2013 and 2014–2015 cohorts with 356 and 204 hemorrhagic events among respective cohorts. Use of cephamycins was associated with a higher risk for hemorrhagic outcomes (aOR 2.03, 95% CI 1.60–2.58). Other risk factors included chronic hepatic disease, at least 65 years old, prominent bleeding tendency, and bleeding history. A nine-score risk scoring system (AUROC = 0.8035, 95% CI 0.7794–0.8275; Hosmer-Lemeshow goodness-of-fit test p = 0.1044) was developed based on the identified risk factors, with higher scores indicating higher risk for bleeding. Use of cephamycins was associated with more hemorrhagic events compared with commonly used penicillins and cephalosporins. The established scoring system, CHABB, may help pharmacists identify high-risk patients and provide recommendations according to the predictive risk, and eventually enhance the overall quality of care.
Synthesis of calcium carbonate nanoparticles in erythrocytes enables efficient removal of extracellular lead ions
Authors: Ru Xiangli , Guo Yuming , Bai Zhengyu , Xie Xiaoxiao , Ma Xiaoming , Zhu Lin , Wang Kui , Wang Feifei , Yang Lin , Lu Jun 
Published: September 2019

AbstractThe “cyborg cells”, living cells with built-in nanoscaffolds, which could integrate the biological function of the cells with the functionality of nanomaterials, have been rarely explored. Here we report a method to construct “cyborg erythrocytes” through the in situ reaction of exogenous calcium and carbonate ions to generate calcium carbonate nanodots inside erythrocytes. The intracellular calcium carbonate nanodots combined with proteins are hidden under the membrane of erythrocytes, which can restrict migration and unexpected accumulation of nanodots in the body, improving the biosecurity of the nanodots. Most importantly, the calcium carbonate nanodots not only do not bring adverse effects on the nature of erythrocytes, but also endow erythrocytes with new properties. The in vitro and in vivo results show that the “cyborg erythrocytes” can remove 80% of lead ions in a blood poisoning model and reduce the lead level in the kidney and liver of mice through a precipitation transformation mechanism.
Effect of Transcutaneous Vagus Nerve Stimulation in Dysphagia After Lateral Medullary Infarction: A Case Report
Authors: Yuan Ying , Wang Jie , Wu Dongyu , Zhang Dahua , Song Weiqun 
Published: September 2019

Purpose
Severe dysphagia with weak pharyngeal peristalsis after dorsal lateral medullary infarction (LMI) requires long-term tube feeding. However, no study is currently available on therapeutic effectiveness in severe dysphagia caused by nuclear damage of vagus nerve after dorsal LMI. The purpose of the present investigation was to explore the potential of transcutaneous vagus nerve stimulation (tVNS) to improve severe dysphagia with weak pharyngeal peristalsis after dorsal LMI.

Method
We assessed the efficacy of 6-week tVNS in a 28-year-old woman presented with persisting severe dysphagia after dorsal LMI who had been on nasogastric feeding for 6 months. tVNS was applied for 20 min twice a day, 5 days a week, for 6 weeks. The outcome measures included saliva spitted, Swallow Function Scoring System, Functional Oral Intake Scale, Clinical Assessment of Dysphagia With Wallenberg Syndrome, Yale Pharyngeal Residue Severity Rating Scale, and upper esophagus X-ray examination.

Results
After tVNS, the patient was advanced to a full oral diet without head rotation or spitting. No saliva residue was found in the valleculae and pyriform sinuses. Contrast medium freely passed through the upper esophageal sphincter.

Conclusion
Our findings suggest that tVNS might provide a useful means for recovery of severe dysphagia with weak pharyngeal peristalsis after dorsal LMI.

Supplemental Material

https://doi.org/10.23641/asha.9755438
Open Ankle Dislocation without Associated Malleolar Fracture on a Trampoline. A Case Report
Authors: Hagebusch Paul , Neun Oliver , Gramlich Yves , Schweigkofler Uwe , Hoffmann Reinhard 
Published: September 2019

AbstractDislocation of the ankle without fracture is very uncommon. There are only few reports in the international literature. Up to now approximately 80 cases are published. The risk of hyperflexion and -inversion of the ankle seems high on a trampoline. A multiple of the jumperʼs body-weight projects delayed on the upper ankle joint while dipping in the trampoline-sheet. Reduction should be performed as fast as possible to ensure a good clinical outcome. Imaging via MRI and CT scan allows a detailed evaluation of the injury severity. The decision for further treatment should be based on the findings in the MRI and CT scans. Reconstructing the medial and lateral capsular ligaments can be necessary. With a consequent treatment algorithm a good functional outcome can be achieved. In our case we documented a post-traumatic AOFAS score of 87/100 six months after the injury without an instability of the upper or lower ankle joint. Propioreceptive reflex and pronator training as well as taping seem to be useful before and during trampoline sports.
Parasitic Infections
Authors: Khubchandani Indru T. , Bub David S. 
Published: September 2019

AbstractParasitic infections of the gastrointestinal tract are a cause of morbidity to millions of individuals worldwide. These parasites are endemic in underdeveloped countries with poor sanitation allowing for spread through contaminated water supplies. While much is known about these parasites, the cutaneous manifestations caused by infection are infrequently reported in the literature. The deposition of the parasites into the perianal region often leads to significant skin irritation. Cutaneous findings vary from a mild pruritus ani to a macular rash to even severe perianal ulceration. This article discusses the perianal cutaneous findings caused by the parasitic illnesses, amebiasis, schistosomiasis, Enterobius vermicularis, strongyloidiasis, and cutaneous larva migrans, as well as their respective management.
Early Antibiotic Prophylaxis Prior to Bypass Surgery Improves Tissue Penetration
Authors: Andreas Martin , Zeitlinger Markus , Shabanian Shiva , Wisser Wilfried , Thell Rainer , Edlinger-Stanger Maximilian , Maier-Salamon Alexandra , Jaeger Walter , Kocher Alfred , Laufer Guenther , Hiesmayr Joerg-Michael , Hutschala Doris 
Published: September 2019

Abstract
Background We previously identified preparation of the internal mammary artery as a risk factor significantly impairing antibiotic tissue penetration into the presternal subcutaneous tissue. We, therefore, adapted our dosing schema regarding preoperative timing to overcome this risk factor.
Methods Eight patients who underwent coronary artery bypass grafting with a left internal mammary artery and vein grafts were included in this clinical trial. Cefazolin (4 g) was administered twice (3 hours and 1 hour) prior to skin incision and once during skin closure (2 g). Antibiotic concentrations were measured with subcutaneous microdialysis probes on both sternal sides. Results were directly compared with the previously published patient cohort receiving the standard schema (4 g cefazolin prior to skin incision and 2 g during closure).
Results All patients (7 male, 1 female, 69 ± 7 years, 26.3 ± 3.9 kg/m2) survived the perioperative period. Mean area under the curve on the right and left sternal side was 117.0 ± 92.5 μg/mL and 114.5 ± 83.2 μg/mL, respectively (p = 0.95). This was well above the previously measured mean peak tissue concentrations without early preoperative antibiotic administration on the side of mammary artery harvesting (52.4 ± 48.5 μg/mL vs. 13.1 ± 5.8 μg/mL; p = 0.039). The %fT > minimal inhibitory concentration (MIC) for Staphylococcus epidermidis and Staphylococcus aureus during the first 10 hours in presternal tissue was ≥ 70% but did not differ compared with standard schema.
Conclusions Early, additional preoperative administration of cefazolin was able to significantly increase peak tissue concentrations during surgery compared with the standard protocol. No difference, however, could be achieved in the percentage of time during which the concentration exceeded the MIC.
Review of Bladder Pain and Referred T12–L2 Input as One Etiology for Interstitial Cystitis
Authors: Dellon A. Lee , Herati Amin S. 
Published: September 2019

Abstract
Background The etiology of interstitial cystitis (IC)/bladder pain syndrome (BPS) remains a mystery. Based on two patients, whose IC/BPS was relieved by resection of injured iliohypogastric (IH) and ilioinguinal (II) nerves, injured by endoscopic prostatectomy in the first patient and a stretch/traction injury in the second patient, a referred pain pathway is hypothesized that can be applied to patients with IC/BPS and previous abdominal wall surgery/injury.
Methods The known neurophysiology of bladder function was reviewed as were the pathways for accepted referred pain syndromes.
Results Perception of bladder filling occurs by impulses generated from stretch receptors in the bladder wall, traveling along visceral afferent fibers that enter the thoracolumbar spinal cord at T12, L1, and L2, the same location as the sympathetic outflow to the viscera and the same location as some of the visceral afferents from the bladder. The II and IH nerves originate from T12, L1, and sometimes L2 somatic, dorsal root ganglia. It is hypothesized that somatic afferent pain impulses, from the lower abdominal wall, are misinterpreted as visceral afferent impulses from the bladder, giving rise to the urinary frequency and urgency of IC/BPS. Resecting injured cutaneous afferents (II and IH) permitted long-term IC/BPS relief in the first patient for 59 months and in the second patient for 30 months. Neural inputs from the sacral visceral afferents and sacral somatic afferents did not appear to be involved in this referred pain pathway.
Conclusion Nerve blocks of the T12 -L2 spinal nerves in patients with bladder pain who also have had abdominal wall surgery/injury may identify IC/BPS patients for whom resection of the II and IH nerves may prove beneficial in obtaining lasting IC/BPS relief.
In Vivo Kinematics of Bicruciate-Retaining Total Knee Arthroplasty with Anatomical Articular Surface under High-Flexion Conditions
Authors: Kono Kenichi , Inui Hiroshi , Tomita Tetsuya , Yamazaki Takaharu , Taketomi Shuji , Tanaka Sakae 
Published: September 2019

AbstractBicruciate-retaining total knee arthroplasty (BCR-TKA) recreates normal knee movement by preserving the anterior cruciate and posterior cruciate ligaments. However, in vivo kinematics of BCR-TKA with the anatomical articular surface remains unknown. The objective of this study was to evaluate in vivo kinematics of BCR-TKA with the anatomical articular surface during high-flexion activities. For this purpose, 17 knees after BCR-TKA with an anatomical articular surface were examined. Under fluoroscopy, each patient performed squatting and cross-legged sitting motions. To estimate the spatial position and orientation of the knee, a two-dimensional or three-dimensional registration technique was used. Rotation, varus-valgus angle, and anteroposterior translation of medial and lateral contact points of the femoral component relative to the tibial component were evaluated in each flexion angle. The results showed that from 80 to 110° of flexion, the femoral external rotation during squatting was significantly larger than that during cross-legged sitting. At maximum flexion, the knees during sitting indicated significantly more varus alignment than during squatting. During squatting, a medial pivot pattern was observed from minimum flexion to 10° flexion, with no significant movement beyond 10° of flexion. Conversely, during cross-legged sitting, no significant movement was detected from minimum flexion to 60° of flexion, with a medial pivot beyond 60° of flexion. Therefore, the knees showed relatively normal kinematics after BCR-TKA with an anatomical articular surface; however, it varied during high-flexion activities depending on the activity.
Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome
Authors: Zhang Qianrui , Zhao Sheng , Zheng Wenxia , Fu Haitan , Wu Tao , Hu Fei 
Published: September 2019

ABSTRACT
Plumbagin (PLB), an alkaloid obtained from the roots of the plants of Plumbago genus, is an inhibitor of NADPH oxidase 4 (NOX4). This study aimed to investigate the beneficial effect of PLB against oxygen-glucose deprivation/reoxygenation (OGDR)-induced neuroinjury in human SH-SY5Y neuronal cultures. Our results showed that OGD/R stimulated NOX4 protein expression and reactive oxygen species (ROS) production in SH-SY5Y cells, whereas increased 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA) production, resulting in the activation of the NLRP3 inflammasome. And PLB pretreatment reduced the ROS production by regulating the expression of NOX4 and downregulated NF-κB signaling which was induced by OGDR. Furthermore, PLB inhibited OGDR induced NLRP3 inflammasome activation but not PARP1. Overall, PLB improved OGDR induced neuroinjury by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.
Relativistic kinematic approach to the classical ideal gas
Authors: Ferrando Joan Josep , Sáez Juan Antonio 
Published: September 2019

Abstract
The necessary and sufficient conditions for a unit time-like vector field to be the unit velocity of a classical ideal gas (CIG) are obtained. In a recent paper (Coll et al 2019 Phys. Rev. D 99 084035) we have offered a purely hydrodynamic description of a CIG. Here we take one more step in reducing the number of variables necessary to characterize these media by showing that a plainly kinematic description can be obtained. We apply the results to obtain test solutions to the hydrodynamic equation that model the evolution in local thermal equilibrium of a CIG.
Reducing the power consumption of two-dimensional logic transistors
Authors: Li Weisheng , Ning Hongkai , Yu Zhihao , Shi Yi , Wang Xinran 
Published: September 2019

AbstractThe growing demand for high-performance logic transistors has driven the exponential rise in chip integration, while the transistors have been rapidly scaling down to sub-10 nm. The increasing leakage current and subthreshold slope (SS) induced by short channel effect (SCE) result in extra heat dissipation during device operation. The performance of electronic devices based on two-dimensional (2D) semiconductors such as the transition metal dichalcogenides (TMDC) can significantly reduce power consumption, benefiting from atomically thin thickness. Here, we discuss the progress of dielectric integration of 2D metal–oxide–semiconductor field effect transistors (MOSFETs) and 2D negative capacitance field effect transistors (NCFETs), outlining their potential in low-power applications as a technological option beyond scaled logic switches. Above all, we show our perspective at 2D low-power logic transistors, including the ultra-thin equivalent oxide thickness (EOT), reducing density of interface trap, reliability, operation speed etc. of 2D MOSFETs and NCFETs.
Revisit of the band gaps of rutile SnO2 and TiO2: a first-principles study
Authors: Cai Xuefen , Zhang Peng , Wei Su-Huai 
Published: September 2019

Abstract
From the recent experimentally observed conduction band offset and previously reported band gaps, one may deduce that the valence band offset between rutile SnO2 and TiO2 is around 1 eV, with TiO2 having a higher valence band maximum. This implication sharply contradicts the fact that the two compounds have the same rutile structure and the Γ3
+ VBM state is mostly an oxygen p state with a small amount of cation d character, thus one would expect that SnO2 and TiO2 should have small valence band offset. If the valence band offset between SnO2 and TiO2 is indeed small, one may question the correctness of the previously reported band gaps of SnO2 and TiO2. In this paper, using first-principles calculations with different levels of computational methods and functionals within the density functional theory, we reinvestigate the long-standing band gap problem for SnO2. Our analysis suggests that the fundamental band gap of SnO2 should be similar to that of TiO2, i.e., around 3.0 eV. This value is significantly smaller than the previously reported value of about 3.6 eV, which can be attributed as the optical band gap of this material. Similar to what has been found in In2O3, the discrepancy between the fundamental and optical gaps of SnO2 can be ascribed to the inversion symmetry of its crystal structure and the resultant dipole-forbidden transitions between its band edges. Our results are consistent with most of the optical and electrical measurements of the band gaps and band offset between SnO2 and TiO2, thus provide new understanding of the band structure and optical properties of SnO2. Experimental tests of our predictions are called for.
Improvement of K-Means Performance Using a Combination of Principal Component Analysis and Rapid Centroid Estimation
Authors: Sapriadi  , Sutarman  , Nababan E B 
Published: September 2019

Abstract
K-Means is a simple clustering algorithm, this method starts with randomizing partitions and continuing to reassign samples to clusters based on similarities between data. However, the K-Means method has several disadvantages, including determining the initial cluster center value done randomly, and the distance model used in determining the similarity between data where conventional distance models have the same effect on each data attribute. In this study will try to improve the performance of K-Means by using a combination of Principal Component Analysis (PCA) and Rapid Centroid Estimation (RCE). PCA will determine the weight of each attribute data based on eigen value, and RCE is used to determine the beginning of the cluster center. To see the performance of the proposed method, this research will use 3 datasets obtained from the UCI Repository, including ionosphere, iris, and wine. Analysis of the performance of the proposed method is only measured based on MSE and SSE. The results of this study indicate that the PCA and RCE methods were able to improve the performance of K-Means, the highest performance improvement based on MSE was found in iris data, which amounted to 56.76%, while based on SSE occurred in the ionosphere data which was 86.08%.
The Use of Multiple MP3 Audio Files for Additional Steganography Capacity
Authors: Indrayani R , Nugroho H A , Hidayat R , Ariyus Dony , Pristyanto Y 
Published: September 2019

Abstract
Steganography is the science and art of hiding secret messages in such a way so that the existence of messages is undetected by human senses. In this paper, multiple MP3 files are used as cover with the aim of increasing steganographic capacity without limiting the number of used files. Concealing secret messages in the form of files on the MP3 file cover can be performed by using homogenous frame. Homogeneous frames in the MP3 files store the bits of the inserted secret files. Before being inserted into some MP3 cover files, secret files are first encrypted employing AES algorithm with passwords implicated by MD5 processes. Audio quality changes between steganography MP3 files and original MP3 files are measured by using stereo signal strength and Mean Opinion Score (MOS). The test results show that the distribution of steganography load on multiple MP3 files can fulfill the user’s needs for the capacity of steganography without reducing the quality of used MP3 files. This paper proposed a method about the increase of steganography capacity which is capable to insert and retrieve secret files on multiple MP3 audio files using homogenous frame utilization methods without resizing and reducing the quality of used MP3 files.
Analysis of Accuracy K-Means and Apriori Algorithms for Patient Data Clusters
Authors: Dharshinni N P , Azmi Fadhillah , Fawwaz I , Husein A M , Siregar Saut Dohot 
Published: September 2019

Abstract
The stacking data is usefull to get a new information. Data mining is a methode to determine the important pattern in Frequent Itemset Mining (FIM). Apriori is part of association rule that is used to determine the assosiative relationship in items combination. But apriori has a high computational time weakness because frequent itemset process searching must scan the database repeatedly for each itemset combination. This study aims to see the effect of the k-means clustering algorithm on the apriori algorithm by combining these two algorithms. The test results show that the combination of k-means and apriori algorithms produces more information detaily and faster time computating than the apriori algorithm with a total computing time of 21.93 minutes and a combination of k-means and apriori algorithms 17.41 minutes.
Analysis and Information System Planning Of Material Requirement Planning Web
Authors: Martyani Eka , Rohayani Hetty , Kurniawan Edy , Febrianti Harlia 
Published: September 2019

Abstract
Many companies that have utilised sophistication system and information With Material Requirement Planning, each work unit can be well coordinated so that it can improve the operational efficiency of each work unit in the company. with this MRP can help to avoid shortages and delays in production, and can immediately identify the amount of inventory needs and transaction costs as well as the accuracy of the use of materials needed so that the warehouse can take appropriate action to meet the specified deadline for transaction costs or usage spare parts, stock of spare parts in the warehouse, and the results of calculating the total spare parts inventory listed on the information material plan needed for the future